bluuebunny/crossref_metadata_2025 huggingface dataset:
Book Review: Steward Leadership in the Nonprofit Organization
Authors: Smith Yvonne S.
Published: May 2024

Tapping into his deep experience, Dr. Kent Wilson has written a readable and well researched book suggesting that leaders in nonprofit firms should embrace steward leadership. Nonprofit leadership, he claims, is a little different from business leadership because the primary identity of the nonprofit leader is as a steward of resources that belong to others. Therefore, steward leadership should be the model for nonprofit leaders.
What If We Are Graduating Utilitarians?
Authors: Herrity Andrew C.
Published: May 2024

Senior undergraduate business students at a Christian university surprise the author during presentations of personally-held values by failing to describe their top value of truthfulness in terms of Christian virtue. This leads to a 30-month grounded theory study. Observations of students’ top value of truthfulness may indicate utilitarian precognitive tacit knowledge, suggesting bias engaged without deliberate thought. Implications are discussed at the end of the paper. Informed by literature on the social psychology of moral decision-making, the author suggests a transformational integration approach may be required for preparing students for the problems associated with Utilitarianism in the marketplace.
Combating the Business Manipulator Using Armor of God: Faith Integration Cycle for Ephesians 6:10-18
Authors: Harrison Adele L. , Geter Stephanie D. , Kaminski Ellen , LaShaw Margie Ness
Published: May 2024

This paper is designed to provide a framework, the Faith Integration Cycle (FIC), for developing,implementing, assessing, and evaluating faith integration in business courses. The paper also demonstrates how faculty—working together—created a multi-disciplinary faith integration effort by providing the theological link between the Bible passage Ephesians 6:10-18 and business disciplines. To assist faculty with faith integration, specific examples of utilizing the FIC are demonstrated with class activities or assignments, including sample syllabus descriptions and grading rubrics. In addition, a general pre- and post-assessment has been provided to assist with the evaluation of the effectiveness of an activity/assignment to achieve faith integration in the classroom. Utilizing the FIC has the potential to be expanded to an entire business program-level faith integration project as suggested by Holder (2006).
Critical Incidents Featuring Christian Businesses: New Research and Publication Opportunities for CBFA Faculty
Authors: Redmer Timothy A. O.
Published: May 2024

Critical incidents featuring Christian businesses represents a very viable research opportunity for CBFA faculty. This research integrates the theoretical with the practical and can result in very relevant teaching instruments with measurable application to learning outcomes and immediate implementation in the classroom. This paper will give the explanation of critical incidents and the steps required to successfully pursue this research opportunity.
Lying Fallow in a Restless World: Using the Bible to Explain the Implications of Rest in Economics
Authors: Barnhart Cora
Published: May 2024

Economic courses pay little attention to the economic implications of insufficient rest. This paper identifies several biblical references to the role of rest with economic implications, examining what the Bible says about the importance of rest for creation and contrasting this with the economic consequences of inad- equate rest. It also provides some specific areas of economics courses where incorporating these connections between biblical guidance on rest and actual examples could be meaningful to students.
Service Learning and Faith Integration in Accounting
Authors: Fowler William E. , Neill John D. , Stovall O. Scott
Published: May 2024

In this paper, we describe a graduate level tax course that we added to our curriculum that was devoted entirely to service learning. Specifically, the major requirement of the course was for our students to participate as volunteer tax return preparers in the Internal Revenue Service’s Voluntary Income Tax Assistance program at a local air force base. The purpose of this paper is to describe how our students grew intellectually, personally, and especially spiritually as a result of their participation in this service learning tax course.
Encouraging Students to Take Responsibility for Their Own Grades: A Systematic Pedagogical Approach
Authors: Chewning Richard C.
Published: May 2024

Students often asked, “Can I do extra work to bring my grade up?” If I said “No,” I would wonder, “Where is my redemptive compassion?” But to say “Yes” could be allowing the students to circumnavigate the consequences of not doing their best from the start. So I instituted a system that required the students to earn a preset number of points to achieve a specific grade. Points were assigned to each grading opportunity: pop quizzes; tests; term papers; book reports; etc. And there were minimum scores set to gain certain opportunities. This paper describes the process, and its results.
Bringing Truth, Joy, and Eternity into the Classroom: Using Perfume to Teach Introductory Marketing
Authors: Filby Ivan L.
Published: May 2024

This paper explains how to reinforce the teaching of basic marketing concepts through a simple group experiential exercise. After dividing the class into small groups, the exercise involves spraying perfume on students’ wrists and instructing each group to develop a marketing plan that targets the segment of the market that they consider to best fit the perfume product. The paper clearly outlines how to prepare and run the exercise, some perfumes that the instructor might consider using, and what students will learn about marketing through the exercise. The paper concludes with some ideas on how to integrate our Christian faith into the learning experience.
Case Study: The Corporate Blame Game: Firestone Tires and the Ford Explorer
Authors: Phillips Mark
Published: May 2024

This case focuses on ethical decision-making during a corporate crisis. Recounting the Ford Explorer/Firestone tire case of 2001, it places students in the boardrooms of the two companies, corporate partners for close to a century who suddenly found themselves fighting for survival. The case includes extensive background information on which to base a decision, questions for use in preparing the case write-up, and a detailed teaching note to simplify class preparation. In classroom testing, this case generated lively debate and convincingly demonstrated the difficulty of objectively interpreting data when one’s corporate survival is at stake.
Case Study: R. W. Beckett Corporation: Corporate Culture
Authors: Redmer Timothy A. O.
Published: May 2024

This case introduces strategic, integrity, and lifestyle issues that make it a suitable case in any class featuring strategic management or ethics discussions. It could be a good case for a capstone course such as strategic planning or an introductory management course. The application of this case has relevance for strategic management and business ethics theory and processes. Regarding strategic management organizational culture is the most relevant issue related to this case scenario. In the area of business ethics, this case could also be presented to support corporate culture. Other secondary topics which might be applicable to the case study include competitive advantage, corporate governance, internal and external environment, product strategy, leadership, and social responsibility.
Salary Study of College Presidents and Faculty: Are Salaries for Institutions in the Council of Christian Colleges and Universities Different from Other Private Institutions?
Authors: Saunders Kent T.
Published: May 2024

This study examines the salaries of college presidents and faculty at private colleges and universities in the United States. This study identifies factors influencing the salary of college presidents and faculty and identifies differences between salaries at member institutions of the Council of Christian Colleges and Universities (CCCU) and non-CCCU schools. Data was gathered from numerous sources (e.g. U.S. NEWS & WORLD REPORT, Marquis Who’s Who, the Integrated Postsecondary Education Data System, and THE CHRONICLE OF HIGHER EDUCATION) in order to compare benchmark salary figures for college presidents and faculty while controlling for size, academic reputation and other institutional variables.
Case Study: Cardone Industries: Chaplain Program
Authors: Redmer Timothy A. O.
Published: May 2024

Cardone Industries – Chaplain Program presents a decision situation where top management had to choose between cost reduction and preserving a visible representation of corporate culture. Over 20 years ago the company founder, Michael Cardone, had implemented a corporate chaplain program to enhance the “Cardone Factory Family” culture of the organization. Over the years, the chaplain service had expanded with the growth of the business to become much more than a religious support system. While the current staff of seven chaplains plus support staff had established several ethnic churches, they also assisted with basic employee needs including medical, social service support, financial, various governmental services, and domestic issues. The program supported benevolence funds, musical groups, family nights, cultural events, sporting activities, and employee recognition programs and awards. An outside consulting group spent 18 months evaluating the overall operations of Cardone Industries in the interest of making the company more competitive and better able to withstand the pressures of the market, competitors, suppliers, and economy with the objective of improving the financial viability of the organization. One of the first recommendations from the consulting group was for Cardone to save an annual cost of $600,000 by eliminating the Chaplain Program. Members of the top management team were both for and against the consultant’s recommendation. Sentiments ran high on both sides and current president Michael Cardone Jr. would have a difficult time reaching a decision.
From Value Creation to Values Creation: The Entrepreneur Enrichment Program as an Enhancement to Business Plan Competitions
Authors: Ataide Randy M.
Published: May 2024

This paper will discuss a co-curricular program innovation, the Entrepreneur Enrichment Program (EEP), within the Fermanian School of Business at Point Loma Nazarene University (PLNU). The EEP seeks to provide an enhancement to traditional collegiate business plan competitions. It is believed by the author that many such competitions unwittingly create an illusion of entrepreneurial success through the development of stylistically attractive and technically acceptable business plans at the expense of providing a more well-balanced personal, professional and relational framework of entrepreneurial and start-up success. It is further contended that overly focusing upon business plan creation and competition may not be the ideal way of transmitting entrepreneurial skills and information to aspiring student-entrepreneurs, especially Christian ones. This paper urges that Christian business schools should consider creating more balanced co-curricular entrepreneurial programs by offering a more relational model of engagement between business mentors and student-entrepreneurs from all academic disciplines and departments. This model should work toward the production of high-quality and market-ready business plans for student-entrepreneur ventures in a modified way from the norm. Ultimately, the EEP seeks to expand the value-creation enterprise of business plans to have the additional component of values-creation.
Book Review: Management: Current Practices And New Directions
Authors: Leaman James M.
Published: May 2024

Book Review: Management: Current Practices And New Directions
Promoting Successful College-to-Workplace Transitions: Examples from Bethel University
Authors: Hannema Charles , LeMay Joyce , Opsata Bethany , Whiting Stephen
Published: May 2024

Life is filled with transitions. One of the toughest is from college to the workplace. Many graduates experience culture shock as they move from the comfort of a Christian college to the reality of the business world. This paper will look at the context and the challenges for workplace transition. It will then review the practices used at one Christian university that have shown effective in preparing students for employment along with theories currently in development to improve workplace transition.
Integration Through Narrative
Authors: Cafferky Michael E.
Published: May 2024

The purpose of this paper is to test the proposition that narrative contains an inherent power for integration of faith, life, and learning of business principles. This is done by a process of reviewing assertions from selected disciplines with the revealed will of God in Scripture. To accomplish this,the paper explores narrative in the context of cultural anthropology, education, business, and religion. From these fields, several parallels can be seen, and several values of narrative for the university business school classroom emerge. The concluding thoughts suggest how instructors can use stories for faith, life, and learning integration.
Viewing Accommodation of Employees’ Disabilities through a Faith Lens
Authors: Wilkerson James M. , Gerdes Darin L.
Published: May 2024

We explore how a biblically-based worldview influences managers’ motivation when attempting to accommodate employees with disabilities. Three issues form the basis of this article: (a) whether the employee with a disability asks for accommodation; (b) the two-way street of responsibility for making accommodation work; and (c) socialization of accommodation via informed co-worker involvement. In covering these issues, we touch on concepts that include operational and administrative efficiency, servant leadership, legal compliance, paternalism, and co-worker relationships.
Love Your God With All Your Mind: The Role of Reason in the Life of the Soul by J. P. Moreland
Authors: Johnson Sharon G.
Published: May 2024

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The Leadership Bible: Leadership Principles from God’s Word (New International Version) by Sid Buzzell
Authors: Johnson Sharon G.
Published: May 2024

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Jesus on Leadership: Discovering the Secrets of Servant Leadership from the Life of Christ by C. Gene Wilkes
Authors: Johnson Sharon G.
Published: May 2024

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Leadership Prayers by Richard Kriegbaum
Authors: Johnson Sharon G.
Published: May 2024

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Building A Culture of Character: An UncommonSense Experience
Authors: Weiant Chip
Published: May 2024

Chip Weiant serves as a principal of CompassUSA, an organizational re-engineering consultancy serving Ohio business CEOs and elected government clients. He also founded and serves as president of The American Center for Civic Character, a non-profit character ethics education initiative. In this article, Weiant shares his leadership ethics guide, called UncommonSense, which has been adopted by the Ohio Secretary of State as a leadership character ethics model for Ohio business and government leaders.
Faith-Learning Integration Exercise: Marketing Principles in the Book of Acts
Authors: Karns Gary L
Published: May 2024

In his study of Acts, Karns finds that the elements of the marketing mix—product, price, place, and promotion—are evident in the expansion of the early church. His Bible study can be used to help students integrate their faith with the marketing discipline.
The Cost of (Un)Ethical Behavior
Authors: Fessler Nicholas J.
Published: May 2024

Fessler shares one of his class lessons as an example of how ethics can be taught in many business classes, whether in a public or private university. This particular lesson focuses on “ethical behavior and its role in a market economy.”
Looking Through New Lenses: Complexity Theory and the Christian Life
Authors: Black Janice A. , Smith Yvonne S.
Published: May 2024

Black and Smith find that complex adaptive systems are useful tools in understanding a complex world and, in actuality, are tools which point directly to Christ. The authors offer ten principles of complex adaptive systems and give the implications of these principles for Christians.
God Is Infinitely WISE: We Have Access to His Wisdom
Authors: Chewning Richard C.
Published: May 2024

In a study of wisdom (God’s wisdom in particular), Chewning presents a hierarchy of definitions and analyzes five core components inherent in God’s wisdom.
Response to “God is Infinitely WISE: We Have Access to His Wisdom”
Authors: Porter Brian E.
Published: May 2024

As expected, Chewning offers a thoughtful and challenging essay developing the hierarchy of knowledge preceding understanding and understanding preceding wisdom. It is always evident, in Chewning’s writings, that he is a sincere and godly man of faith who endeavors to disciple others.
Firstfruits
Authors: Stewart Jonathan D.
Published: May 2024

Stewart explains how he uses the biblical principle of firstfruits to integrate faith and learning in his financial management class.
Building A Marketing Case Around A Campus Ministry
Authors: Clark A. Bruce
Published: May 2024

By using Christian organizations for marketing case studies, Clark enriches his marketing class while presenting fundamentals of the Christian faith.
Assisted suicide: Ethical considerations and the South African debate
Authors: Van Eeden A
Published: May 2024

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Love Letters to My Child in These Hate-Filled Times
Authors: Vasudevan Pavithra
Published: May 2024

In a series of three letters, Pavithra describes to their unborn child what it’s like to be pregnant. The first conveys the terror of carrying a new being into a violently homophobic and racist world. The second and third letters recall the desire and beauty that the unborn child sparks in them. In the fourth letter, Pavithra writes to Noor Momo, now six years old, reflecting on the realities of parenting amidst ongoing violence and the uncertainties of the COVID-19 pandemic. In this final letter, Pavithra invokes Noor’s aunts: her sister Raksha, and her dear friends Kriti, Batool, Mabel, and Marie. The words Chitthi, Masi, Khala and Chyama refer to “mother’s sister” in Tamil, Hindi, Urdu, and Nepali, respectively.
Bezvadu elektroenerģijas pārvade
Authors:   , Stepins Deniss , Zaķis Jānis
Published: May 2024

Grāmatā apskatīta bezvadu elektroenerģijas pārvades attīstības vēsture, lietošana, klasifikācija, parametri un standarti. Atsevišķa nodaļa veltīta dažādu bezvadu pārvades metožu apskatam, lielāko uzmanību pievēršot rezonanses induktīvās pārvades metodei. Grāmatā ir arī sniegta detalizēta informācija par bateriju bezvadu uzlādes ierīcēm, kuru darbības pamatā ir rezonanses induktīvās pārvades metode. Mācību grāmata būs noderīga studentiem, kuri apgūst elektroniku un enerģētiku, skolēniem, kuri apgūst padziļināto fizikas kursu, kā arī visiem, kas interesējas par energoapgādi, elektroenerģijas pārvadi un izmantošanu.
Bioactivity and enzymatic properties of culturable endophytic fungi associated with black seeds (Nigella sativa L.)
Authors: Gopane Boitshepo , Kaptchouang Christ-Donald Tchatchouang , Regnier Thierry , Ateba Collins Njie , Manganyi Madira
Published: May 2024

Extracellular enzymes of the endophytes are degraders of the polysaccharides available in the host plants. The study evaluated the activity of amylase, protease, lipase, and laccase enzymes produced by one hundred endophytes previously isolated from the seed. In addition, their antimicrobial activity against Listeria monocytogenes, Staphylococcus aureus (ATTC 25923), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853) was determined using the disc diffusion assay. The data show that 93% of the isolates were capable of producing amylase, followed by protease, lipase, and laccase with 72%, 81%, and 10%, respectively. Out of 100 endophytic fungi, only nineteen (n = 19) displayed activity against the target bacteria. Of the 19 endophytic fungi showing antibacterial activity, 9 (47%) belonged to the Penicillium genus, 5 (26%) to Alternaria spp, 3 (16%) to Cladosporium, and only 1 (5%) to the Fusarium genus. The highest antibacterial activities against all pathogenic bacteria tested were recorded for Alternaria alternata (MH879772.1) and Penicillium goetzii (MF151170.1). In conclusion, the study not only demonstrates the array of extracellular enzymes produced by the endophytes isolated from black seeds but also reports on their antibacterial properties, thus highlighting the importance of these endophytes in the development of endophyte-based technologies and drug development against resistance pathogenic bacteria.
RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia
Authors: Yu Xiaozhuo , Zhou Wen , Chen Xiaodong , He Shunyu , Qin Mengting , Yuan Meng , Wang Yang , Odhiambo Woodvine otieno , Miao Yinsha , Ji Yanhong
Published: May 2024

The evolutionary conservation of non-core RAG regions suggests significant roles that might involve quantitative or qualitative alterations in RAG activity. Off-target V(D)J recombination contributes to lymphomagenesis and is exacerbated by RAG2’ C-terminus absence in Tp53
-/-
mice thymic lymphomas. However, the genomic stability effects of non-core regions from both cRAG1 and cRAG2 in
BCR-ABL1
+
Blymphoblastic leukemia (
BCR-ABL1
+
B-ALL), the characteristics, and mechanisms of non-core regions in suppressing off-target V(D)J recombination remains unclear. Here, we established three mouse models of
BCR-ABL1
+
B-ALL in mice expressing full-length RAG (fRAG), core RAG1 (cRAG1), and core RAG2 (cRAG2). The cRAG (cRAG1 and cRAG2) leukemia cells exhibited greater malignant tumor characteristics compared to fRAG cells. Additionally, cRAG cells showed higher frequency of off-target V(D)J recombination and oncogenic mutations than fRAG. We also revealed decreased RAG cleavage accuracy in cRAG cells and a smaller recombinant size in cRAG1 cells, which could potentially exacerbate off-target V(D)J recombination in cRAG cells. In conclusion, these findings indicate that the non-core RAG regions, particularly the non-core region of RAG1, play a significant role in preserving V(D)J recombination precision and genomic stability in
BCR-ABL1
+
B-ALL.
Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt
Authors: Erice Phillip A , Huang Xinyan , Seasock Matthew J , Robertson Matthew J , Tung Hui-Ying , Perez-Negron Melissa A , Lotlikar Shivani L , Corry David B , Kheradmand Farrah , Rodriguez Antony
Published: May 2024

Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. The let-7 microRNA (Mirlet7 miRNA) family is associated with IL-17-driven T cell inflammation, a canonical signature of lung inflammation. Recent evidence suggests the Mirlet7 family is downregulated in patients with COPD, however, whether this repression conveys a functional consequence on emphysema pathology has not been elucidated. Here, we show that overall expression of the Mirlet7 clusters, Mirlet7b/Mirlet7c2 and Mirlet7a1/Mirlet7f1/Mirlet7d, are reduced in the lungs and T cells of smokers with emphysema as well as in mice with cigarette smoke (CS)- or nCB-elicited emphysema. We demonstrate that loss of the Mirlet7b/Mirlet7c2 cluster in T cells predisposed mice to exaggerated CS- or nCB-elicited emphysema. Furthermore, ablation of the Mirlet7b/Mirlet7c2 cluster enhanced CD8+IL17a+ T cells (Tc17) formation in emphysema development in mice. Additionally, transgenic mice overexpressing Mirlet7g in T cells are resistant to Tc17 and CD4+IL17a+ T cells (Th17) development when exposed to nCB. Mechanistically, our findings reveal the master regulator of Tc17/Th17 differentiation, RAR-related orphan receptor gamma t (RORγt), as a direct target of Mirlet7 in T cells. Overall, our findings shed light on the Mirlet7/RORγt axis with Mirlet7 acting as a molecular brake in the generation of Tc17 cells and suggest a novel therapeutic approach for tempering the augmented IL-17-mediated response in emphysema.
Functional characteristics and computational model of abundant hyperactive loci in the human genome
Authors: Hudaiberdiev Sanjarbek , Ovcharenko Ivan
Published: May 2024

Enhancers and promoters are classically considered to be bound by a small set of transcription factors (TFs) in a sequence-specific manner. This assumption has come under increasing skepticism as the datasets of ChIP-seq assays of TFs have expanded. In particular, high-occupancy target (HOT) loci attract hundreds of TFs with often no detectable correlation between ChIP-seq peaks and DNA-binding motif presence. Here, we used a set of 1003 TF ChIP-seq datasets (HepG2, K562, H1) to analyze the patterns of ChIP-seq peak co-occurrence in combination with functional genomics datasets. We identified 43,891 HOT loci forming at the promoter (53%) and enhancer (47%) regions. HOT promoters regulate housekeeping genes, whereas HOT enhancers are involved in tissue-specific process regulation. HOT loci form the foundation of human super-enhancers and evolve under strong negative selection, with some of these loci being located in ultraconserved regions. Sequence-based classification analysis of HOT loci suggested that their formation is driven by the sequence features, and the density of mapped ChIP-seq peaks across TF-bound loci correlates with sequence features and the expression level of flanking genes. Based on the affinities to bind to promoters and enhancers we detected five distinct clusters of TFs that form the core of the HOT loci. We report an abundance of HOT loci in the human genome and a commitment of 51% of all TF ChIP-seq binding events to HOT locus formation thus challenging the classical model of enhancer activity and propose a model of HOT locus formation based on the existence of large transcriptional condensates.
Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing
Authors: Huang Yiwei , Wu Gujie , Bi Guoshu , Cheng Lin , Liang Jiaqi , Li Ming , Zhang Huan , Shan Guangyao , Hu Zhengyang , Chen Zhencong , Lin Zongwu , Jiang Wei , Wang Qun , Xi Junjie , Yin Shanye , Zhan Cheng
Published: May 2024

Chemotherapy is widely used to treat lung adenocarcinoma (LUAD) patients comprehensively. Considering the limitations of chemotherapy due to drug resistance and other issues, it is crucial to explore the impact of chemotherapy and immunotherapy on these aspects. In this study, tumor samples from nine LUAD patients, of which four only received surgery and five received neoadjuvant chemotherapy, were subjected to scRNA-seq analysis. In vitro and in vivo assays, including flow cytometry, immunofluorescence, Seahorse assay, and tumor xenograft models, were carried out to validate our findings. A total of 83,622 cells were enrolled for subsequent analyses. The composition of cell types exhibited high heterogeneity across different groups. Functional enrichment analysis revealed that chemotherapy drove significant metabolic reprogramming in tumor cells and macrophages. We identified two subtypes of macrophages: Anti-mac cells (CD45+CD11b+CD86+) and Pro-mac cells (CD45+CD11b+ARG +) and sorted them by flow cytometry. The proportion of Pro-mac cells in LUAD tissues increased significantly after neoadjuvant chemotherapy. Pro-mac cells promote tumor growth and angiogenesis and also suppress tumor immunity. Moreover, by analyzing the remodeling of T and B cells induced by neoadjuvant therapy, we noted that chemotherapy ignited a relatively more robust immune cytotoxic response toward tumor cells. Our study demonstrates that chemotherapy induces metabolic reprogramming within the tumor microenvironment of LUAD, particularly affecting the function and composition of immune cells such as macrophages and T cells. We believe our findings will offer insight into the mechanisms of drug resistance and provide novel therapeutic targets for LUAD in the future.
Genetic stability of Mycobacterium smegmatis under the stress of first-line antitubercular agents
Authors: Molnár Dániel , Surányi Éva Viola , Trombitás Tamás , Füzesi Dóra , Hirmondó Rita , Toth Judit
Published: May 2024

The sustained success of Mycobacterium tuberculosis as a pathogen arises from its ability to persist within macrophages for extended periods and its limited responsiveness to antibiotics. Furthermore, the high incidence of resistance to the few available antituberculosis drugs is a significant concern, especially since the driving forces of the emergence of drug resistance are not clear. Drug-resistant strains of Mycobacterium tuberculosis can emerge through de novo mutations, however, mycobacterial mutation rates are low. To unravel the effects of antibiotic pressure on genome stability, we determined the genetic variability, phenotypic tolerance, DNA repair system activation, and dNTP pool upon treatment with current antibiotics using Mycobacterium smegmatis. Whole-genome sequencing revealed no significant increase in mutation rates after prolonged exposure to first-line antibiotics. However, the phenotypic fluctuation assay indicated rapid adaptation to antibiotics mediated by non-genetic factors. The upregulation of DNA repair genes, measured using qPCR, suggests that genomic integrity may be maintained through the activation of specific DNA repair pathways. Our results, indicating that antibiotic exposure does not result in de novo adaptive mutagenesis under laboratory conditions, do not lend support to the model suggesting antibiotic resistance development through drug pressure-induced microevolution.
INJERTO AUTÓLOGO PARA LA PREVENCIÓN DE DEFECTOS MUCOSOS EN IMPLANTE UNITARIO MAXILAR. REVISIÓN SISTEMÁTICA
Authors: Carreño-Gutiérrez Felipe , Becerra-Henríquez Joaquín , Klahn-Acuña Blanca , Fuentes-Barría Héctor , Aguilera-Eguía Raúl , Polevoy Georgiy
Published: May 2024

INTRODUCCIÓN: Los injertos autólogos de tejido blando son fundamentales como ayuda para la preservación de la estabilidad del implante bucal, siendo apreciados por la suministración de un aspecto estético adecuado. OBJETIVO: actualizar la información sobre la aplicación de injertos de tejido autólogo para la prevención de defectos mucosos periimplantarios. MATERIALES Y MÉTODOS: Se realizó una búsqueda electrónica entre los años 2018 y 2022 utilizando la estrategia de búsqueda “Soft tissues AND Grafting AND Dental implants” en el metabuscador Epistemonikos y las bases de datos Scopus y Medline / Pubmed. RESULTADOS: La búsqueda reporto 279 registros de los cuales 3 cumplieron con los criterios de elegibilidad, cuyos resultados indican que los injertos tienen la capacidad de generar ganancia volumétrica y mantener el nivel de tejido blando, siendo el injerto autólogo es el más eficaz. CONCLUSIONES: El uso de injerto autólogo aumenta la cantidad de tejido blando periimplantario a corto plazo previniendo la aparición de defectos mucosos.
REFLEXIÓN DE LOS DETERMINANTES Y ETIQUETAS SOCIALES SOBRE LA DIABETES TIPO 2 EN JÓVENES
Authors: Orozco Naranjo Perla , Gutiérrez Valverde Juana Mercedes
Published: May 2024

INTRODUCCIÓN: La diabetes tipo 2 (DT2) en jóvenes es producida por factores modificables y no modificables, encontrándose inmersos determinantes sociales que influyen de manera potencial para su desarrollo. OBJETIVO: Reflexionar sobre los determinantes y etiquetas sociales sobre la DT2 en jóvenes y como estos pueden ayudar al entendimiento del fenómeno de estudio y contribuir en su prevención, a través de la epidemiología sociocultural. DESARROLLO: En un primer momento, se crea una estructura de jerarquía que abarca diferentes niveles, como el macro (edad, educación, ingresos, posición socioeconómica, clase social y etnia), meso (red social, estrés y acceso a los servicios de salud) y el micro (estilos de vida). Posterior, se analiza cómo se genera construcciones de etiquetas sociales relacionadas con la DT2 en jóvenes. Por último, se examinan las medidas de intervención sociales y de salud actuales mundiales y en México para reducir los comportamientos de riesgo vinculados al desarrollo de la DT2. CONCLUSIÓN: La DT2 en jóvenes representa un problema en crecimiento, y es fundamental que se desarrollen y ejecuten políticas de prevención y promoción de la salud dirigidas a este grupo de edad, siendo primordial que la enfermería como profesión se involucren en este ámbito con el con el propósito de influir en los determinantes sociales que impactan a la DT2.
Aglomerados produtivos como estratégia de desenvolvimento das panificadoras potiguares
Authors: Vasconcelos César Ricardo Maia , Aouar Walid Abbas El , Santos Suely Xavier dos , Moçambite Viviane da Silva Costa Novo
Published: May 2024

O objetivo deste “artigo de investigação” é o de identificar e analisar não apenas as motivações, mas igualmente às ações estratégicas e os benefícios relacionados as panificadoras potiguares. Do ponto de vista da abordagem do problema este estudo de caso se apresenta do tipo quantitativo e qualitativo. A metodologia contemplou a pesquisa bibliográfica e de campo, com aplicação de questionário aos empresários do arranjo produtivo local de panificação. Os resultados indicam que as micro e pequenas empresas percebem como principais motivações as externalidades marshallianas e institucionais; as ações estratégicas têm como foco as perspectivas de mercado, do aprendizado e crescimento e os maiores benefícios estão compreendidos nas abordagens de cluster e milieu inovador.
Educação corporativa em ambientes virtuais: uma abordagem da administração estratégica na contemporaneidade
Authors: Fernandes Allysson Barbosa , Farias Júnior Tácito Augusto , Soares João Luis Josino , Rezende Guelly Urzêda de Mello , Fukuoka Danilo Marcos Leme , Leite Jaqueline Conceição , Rodrigues Katia Silene Macedo de Medeiros , Melo Júnior Hermócrates Gomes , Pereira João Alves , Martins Paula Welliana Araujo , Reis Bárbara Damasio dos
Published: May 2024

Este artigo apresenta uma revisão de literatura sobre o papel da Educação Corporativa (EC) na formação de competências e na produção de conhecimento nas organizações. O objetivo geral é investigar como a EC contribui para o desenvolvimento de competências e para a disseminação do conhecimento no ambiente corporativo. A metodologia utilizada consiste em uma revisão abrangente da literatura existente sobre o tema, incluindo pesquisas qualitativas que exploram diferentes abordagens teóricas, a partir de uma busca fazendo uso de descritores e de critérios de exclusão, identificamos nove artigos que se relacionaram com o estudo. Os resultados destacam que a EC desempenha um papel fundamental na integração de um sistema educacional com os objetivos organizacionais, promovendo o aprendizado contínuo e ativo por meio de múltiplas tecnologias de aprendizagem. Além disso, a revisão da literatura revela que a EC pode auxiliar na delimitação do problema de pesquisa, na identificação de novas linhas de investigação e na prevenção de abordagens infrutíferas. A análise das pesquisas anteriores também aponta para a importância de se considerar diferentes paradigmas teóricos ao investigar o papel da EC na formação de competências e na produção de conhecimento organizacional. Em suma, este estudo destaca a relevância da EC como uma estratégia-chave para o desenvolvimento de competências e para a promoção do aprendizado contínuo nas organizações.
“Campanha Setembro Amarelo”: relato de experiência todos contra o suicídio
Authors: Guimarães Michelle Firmino , Mota Marinete Lourenço , Castro Ingrid Olímpio Castelo Branco , Benincasa Miria
Published: May 2024

O tema suicídio é frequente em clínicas médicas psiquiátricas e psicológicas, se constituindo em uma epidemia silenciosa em todo o globo. A Campanha Setembro Amarelo visa estimular a divulgação do tema, buscando prevenir novos casos Em um momento no qual o mundo celebra a conquista de uma redução de 20% nas taxas de suicídio ao longo dos últimos 22 anos (OMS, 2023), o Brasil, infelizmente, enfrenta uma realidade contrastante, com preocupante aumento de 25% no mesmo período. Este projeto Campanha Setembro Amarelo: todos contra o suicídio - desenvolvido no Instituto de Natureza e Cultura (INC/UFAM)  como ação de enfrentamento ao suicídio principalmente entre os discentes indígenas, teve como objetivos: desenvolver atividades de prevenção e sensibilização do suicídio através de Plantão Psicológico, garantindo atenção psicológica por meio do encontro face a face, escuta qualificada.  Trata-se de um relato de experiência, cujo método teve como aporte a contribuição de estratégias teóricas e técnicas baseadas nas áreas de conhecimento dos profissionais participantes: Psicologia Clínica, Saúde, Pedagogia e Assistência Social. Como resultados serão descritas diferentes ações desenvolvidas pela equipe, tais como: rodas de conversas, videoconferências, caminhadas, atendimentos psicológicos em parcerias com voluntários que abraçaram o projeto, etc. Conclui-se que ações como essa são de grande importância em instituições de ensino superior, visto ser caracterizadas por um público de diferentes classes sociais, etnias, culturas que podem estar sendo atingidos por dores psicológicas extremas. Oportunidades como essa, favorecem a possibilidade de falar sobre as dores e encaminhá-las para cuidado especializado.
Sustainability through the use of Building Information Modelling in infrastructure planning
Authors: Rexhaj Gentjana
Published: May 2024

This study examines the role of Building Information Modelling (BIM) in infrastructure planning from a sustainability perspective. It emphasises how BIM can contribute to the promotion of ecological, economic and social sustainability. Interviews with experts have shown that BIM can not only optimise the energy consumption of infrastructure projects, but also lead to precise material quantification and optimisation. Despite the benefits, the use of BIM in infrastructure planning is limited, especially in small and medium-sized projects and with local authorities. The study identifies challenges such as the complexity of BIM software systems and the additional costs of implementing them. Recommendations for action include training clients and engineering firms in the use of BIM for cost forecasting and extending the digital twin concept beyond the construction and planning process. The results show that widespread BIM application is only possible if both clients and planning offices share sustainability goals and are prepared to bear the additional costs for BIM planning. The work emphasises the need to use BIM beyond building construction for sustainable infrastructure development and provides insights into the practice of engineering firms in the infrastructure sector.
Comprehensive Management of Ovarian Tumour-related Torsion: A Case Report
Authors: Gupta Deepakshi , Kose Varsha
Published: May 2024

Ovarian tumours are diverse and lead to rare yet critical complications such as torsion. The ovary twists on its own axis and compromises blood flow. Ovarian torsion is uncommon and has considerable risk in women of reproductive age. The present case report elucidates the intricate nature of ovarian tumours, particularly emphasising the rare yet critical complication of torsion, where the ovary twists, compromising blood flow. The presented case involves a 35-year-old multiparous woman with acute abdominal pain, vomiting, and elevated Cancer Antigen 125 (CA-125) levels, leading to the diagnosis of a left ovarian cyst with torsion via Ultrasonography (USG). The subsequent surgical intervention, involving exploratory laparotomy, successfully confirmed and addressed the issue, resulting in detorsion and cystectomy. Histopathological examination further identified a benign serous cystadenoma. The present case underscores the diagnostic challenges associated with ovarian tumour-related torsion, highlighting the importance of symptom analysis and diagnostic imaging for early recognition. It also emphasises the effectiveness of surgical intervention, showcasing varied treatment options, from cystectomy to detorsion, contingent on individual circumstances. The present case report stresses the imperative of a multidisciplinary approach involving gynaecologists, radiologists and surgeons for optimal outcomes in managing this complex condition.
Perinatal Outcome of Twin Pregnancies in Relation to Chorionicity at a Tertiary Care Centre in Central Kerala, India: A Prospective Cohort Study
Authors: Hridya P , Deepak AV , Reena RP
Published: May 2024

Introduction: In recent years, there has been a significant increase in the incidence of multiple births due to advanced maternal age at conception and the growing use of infertility treatment. Multiple pregnancies are associated with both maternal and perinatal complications. Maternal complications include anaemia, gestational hypertension, gestational diabetes, preterm labour, operative delivery and postpartum haemorrhage. Preterm birth, growth discordance and complications specific to monochorionic twins predispose these babies to adverse perinatal outcomes. Aim: To assess the perinatal outcomes of twin pregnancies and compare the outcomes of monochorionic and dichorionic pregnancies. Materials and Methods: The present prospective cohort study was conducted in the Department of Obstetrics and Gynaecology, Government Medical College (Tertiary care centre), Thrissur, Kerala, India, from September 2019 to August 2020. All twins who delivered at a gestational age of ≥28 weeks during the study period were recruited, totaling 76 twin pregnancies. A structured proforma was used to collect demographic and clinical details, including mode of conception, chorionicity, maternal complications, intrapartum events and neonatal outcomes. Data were analysed using Epi Info software. Results: The mean maternal age of the study participants was 28.39±6.29 years. The incidence of twin pregnancies delivering at ≥28 weeks at Government Medical College, Thrissur, during the study period was 2.8% (76 twins out of 2709 deliveries). Infertility treatment (ovulation induction alone or Assisted Reproductive Techniques (ART) was associated with dichorionic twinning in 19.7% (15 out of 76 twin pregnancies), with a p-value of 0.008. Maternal complications were similar in both dichorionic and monochorionic twins. Preterm Premature Rupture of Membranes (PPROM) occurred in 23 (28.75%) twin pregnancies, 19 (23.75%) had Gestational Diabetes Mellitus while 13 (16.25%) participants had anaemia. Foetal growth restriction, congenital anomalies, and discordant growth were more prevalent in monochorionic twin pregnancies compared to dichorionic twin pregnancies. Although the proportion of babies requiring Neonatal Intensive Care Unit (NICU) admission was higher in monochorionic twins (64% vs 53.9%), the proportion of neonatal deaths was nearly equal between monochorionic and dichorionic twins (10% vs 9.8%). Conclusion: In the present study, there was no statistical difference in maternal complications between monochorionic and dichorionic twins. However, monochorionic pregnancies had a poorer perinatal outcome compared to dichorionic pregnancies.
Primary Hydatid Cysts in Rare Sites: A Series of Four Cases
Authors: Singh Deepali , Khetawat Ritu , Halder Doyel , Mondal Madhumita , Mallik Mamata Guha
Published: May 2024

Hydatid disease is caused by the larval stage of the tapeworm Echinococcus granulosus. The definitive hosts include dogs and canines. Humans are accidental hosts and do not play a role in the biological cycle of the worm. The mode of infection is through ingesting food contaminated with dog feces containing gravid proglottids and free eggs, which hatch in the intestine and form larvae. The larvae then penetrate the intestinal wall, enter the bloodstream, and typically settle in the liver followed by the lungs. However, in rare instances, hydatid cysts can occur in various unusual sites throughout the body and even in a disseminated manner, leading to atypical clinical presentations and diagnostic challenges. Hereby, authors report a series of four cases (three males and one female) of hydatid cysts occurring at unusual sites, mainly the brain, kidney, spleen, and lung. The common age group among the observed cases was the second to fourth decade, showing a male predominance. In cases of splenic and renal hydatid cysts, patients presented with intermittent dull aching pain over the left and right flanks, respectively. In both cases, ultrasonography revealed the presence of multiple cysts in the spleen and kidney. In the case of cerebral hydatid cysts, the patient provided a history of short-term memory loss along with a few non specific symptoms, and Magnetic Resonance Imaging (MRI) revealed a hyperintense cystic lesion. In pulmonary hydatid cysts, the patient presented with symptoms of cough, dyspnoea, chest pain, and expectoration. X-ray examination supported the presence of the cyst. Surgery, preferably radical cystectomy, is considered for treatment, and the diagnosis is always confirmed by histopathology.
AZERBAYCAN SOVYET SOSYALİST CUMHURİYETİ PİYONER TEŞKİLATINDA ÇOCUKLARA YÖNELİK VERİLEN OKUL DIŞI KORO EĞİTİMİ
Authors: Mammadalıyev Mammadalı , Erol Türker
Published: May 2024

Bu makalede Sovyetler dönemi Azerbaycan’da çocuklara yönelik okul dışı kurumlarda müzik eğitimi veren koro derneklerinde yapılan çalışmalar ele alınmıştır. Araştırma doküman incelemesi yöntemiyle gerçekleştirilmiş olup, Azerbaycan Sovyet Sosyalist Cumhuriyeti’ndeki (ASSC) okul dışı koro derneklerinin kuruluşu, işleyişi, organizasyonu ve amaçları ele alınmıştır. Verilerin toplanmasında koro eğitimi ile ilgili o dönem yazılmış L. Şamina’nın (Л. Шамина) “Okul dışı koro topluluklarıyla çalışmalar” (Работа с самодеятельным хоровым коллективом), R. Kurbanov’un (Р. Гурбанов) “Okul dışı faaliyet kapsamında müzik dernekleri” (Өзфəалиjjəт мусиги дəрнəҝлəри), ve L. Abelyan’ın (Л. Абелян) “Okul ve okul dışı kurumlar için programlar” (Программы для внешкольных учреждений и общеобразовательных школ) adlı metotlar ve konu ile ilgili arşiv belgelerinden faydalanılmıştır. Elde edilen veriler doğrultusunda o dönem kurulan koro topluluklarının organizasyon ve işleyiş bakımından oldukça sistemli bir yapıya sahip olduğu görülmektedir. Ayrıca kurulan koro dernekleri ve bu derneklerin yürüttüğü faaliyetlerin rejimin ideolojik amaçları doğrultusunda bir propaganda sahası olduğu söylenebilir.