bluuebunny/crossref_metadata_2025 huggingface dataset:
Lahirnya Hak Tanggungan Menurut Peraturan Pemerintah Agraria Tentang Pelayanan Hak Tanggungan Terintegrasi Secara Elektronik
Authors: Imanda Nadia
Published: May 2020

Ketentuan-ketentuan mengenai hak tanggungan mengacu pada Undang-Undang Nomor 4 Tahun 1996 (UU HT) serta peraturan-peraturan pelengkap lainnya. Seiring berjalannya waktu, pemerintah Indonesia dalam penerapannya bercita-cita untuk meningkatkan pembangunan nasional bertitik berat pada bidang ekonomi, dalam hal tersebut dibutuhkan penyediaan dana yang cukup, sehingga memerlukan Lembaga hak jaminan kuat, mampu memberikan kepastian hukum bagi pihak-pihak yang berkepentingan, mendukung kegiatan bisnis, efektif dan efisien. Oleh karena itu, pelaksanaan pembebanan hak tanggungan dilakukan penyederhanaan proses dengan diterbitkannya Peraturan Menteri Agraria dan Tata Ruang/ Kepala Badan Pertanahan Nasional Nomor 9 Tahun 2019 tentang Pelayanan Hak Tanggungan Terintegrasi Secara Elektronik. Dengan terbitnya Permen Agraria tersebut, pemerintah Indonesia bertujuan untuk meningkatkan pelayanan hak tanggungan yang memenuhi asas keterbukaan, ketetapan waktu, kecepatan dan kemudahan membuat konsep terhadap momentum lahirnya Hak Tanggungan secara sah menjadi kabur. Pada Hak Tanggungan melekat asas publisitas, yang menjadi syarat lahirnya Hak Tanggungan tersebut, maka pencatatan dalam buku tanah dilakukan guna memenuhi asas publisitas yang menjadikan Hak Tanggungan itu terbuka dan umum, sehingga pihak lain yang tidak terikat pada perjanjian jaminan itu mengetahui bahwa adanya hak kebendaan di atas hak atas tanah tersebut. Sehingga, dengan adanya HT-el tidak menghapusnya adanya kewajiban untuk memenuhi syarat publisitas agar diketahui oleh masyarat.
Peranan Desa Wongsorejo Dalam Penyelenggaraan Perlindungan Hak Anak
Authors: Kristianti Dwi Rahayu , W.P. Zendy Wulan Ayu , Widiati Ekawestri Prajwalita
Published: May 2020

Artikel ini adalah merupakan luaran dari kegiatan pengabdian masyarakat dengan judul Pendampingan Desa Wongsorejo Dalam Pelaksanaan Program Perlindungan Anak Terpadu Berbasis Masyarakat (PATBM) yang dilaksanakan pada tahun 2019. Program pengabdian masyarakat dilaksanakan di Desa Wongsorejo, Banyuwangi. Desa ini dipilih karena mengingat bahwa masyarakat baru mulai memiliki kesadaran akan pentingnya hak anak. Lebih lanjut, upaya perlindungan dan pemenuhan hak anak yang dilakukan di desa masih belum terpadu. Padahal di tahun 2016, Kementrian Pemberdayaan Perempuan dan Anak telah mengeluarkan suatu pedoman Perlindungan Anak Terpadu Berbasis Masyarakat (PATBM). Bentuk kegiatan pengabdian masyarakat ini adalah pendampingan kepada masyarakat Desa Wongsorejo dalam pelaksanaan programPerlindungan Anak Terpadu Berbasis Masyarakat (PATBM) mulai dari tahapan sosialisasi hak-hak anak kepada masyarakat sampai dengan penyusunan model perlindungan anak terpadu dengan melibatkan partisipasi anak dan masyarakat desa. Untuk luaran yang ingin dicapai dalam kegiatan ini adalah publikasi jurnal ilmiah dan media cetak, serta penyusunan model perlindungan anak sesuai dengan aspirasi anak dan masyarakat desa. Hal ini untuk menuju desa ramah anak yang menjamin terpenuhinya hak-hak anak dan berorientasi pada kepentingan terbaik bagi anak.
Keabsahan Bukti Lama Berupa Letter C Desa Dalam Kepemilikan Hak Atas Tanah
Authors: Sadjarwo Irsyadilla Hafizh Heru
Published: May 2020

Pertanahan merupakan kebutuhan primer dalam kehidupan saat ini baik untuk keperluan tempat tinggal, usaha, dan investasi. Indonesia baru mempunyai Undang-Undang Pokok Agraria sendiri pada tahun 1960. Banyak pihak  yang masih memegang bukti-bukti lama kepemilikan hak atas tanah yang telah diperoleh sebelum adanya UUPA salah satunya yang dianalisis dalam penelitian ini yaitu Letter C Desa. Dalam menilai kebsahan dari Letter C Desa ini perlu didasarkan pada syarat sahnya suatu keputusan yaitu wewenang, prosedur, dan objek yang sesuai serta perlu menberdasarkan UUPA, Peraturan Pemerintah tentang Pendaftaran Tanah, dan peraturan perundang-undangan lain yang berkaitan. Apakah kedudukan bukti lama berupa Letter C Desa dalam kepemilikan hak atas tanah? Apa perlindungan hukum bagi pemegang bukti lama berupa Letter C Desa dalam kepemilikan hak atas tanah?. Hasil dari peneilitan ini menunjukan bahwa Letter C Desa merupakan bukti lama dalam kepemilikan hak atas tanah yang dapat digunakan dalam kegiatan pendaftaran tanah dan perlindungan hukum bagi pemegang bukti lama dapat dilakukan musyawarah mufakat oleh Ketua Panitia Ajudikasi dalam kegiatan pendaftaran tanah secara sistematis dan oleh Kepala Kantor Pertanahan dalam kegiatan pendaftaran tanah secara sporadik. Apabila ada pihak yang tetap keberatan dapat mengajukan gugatan ke Pengadilan Negeri atas bukti-bukti lama tersebut.
La recherche équine en France et dans le monde au travers d’une analyse bibliométrique
Authors: CLEMENT F. , BASSECOULARD E.
Published: May 2020

Pour obtenir un panorama actuel de la recherche équine en France et dans le monde, une étude bibliométrique a été réalisée à partir des publications scientifiques concernant le cheval et recensées dans les bases CAB abstracts de CAB International et Current Contents de l’Institute for Scientific Information au cours des années 1998-2000. Après une structuration thématique combinant méthodes bibliométriques et avis d’experts, ces articles ont été ventilés en fonction des thématiques étudiées, des localisations des équipes signataires et du support de communication. Le fichier final comporte 6775 publications, pour deux tiers issues de journaux scientifiques, 31 % provenant de journaux de transfert et 6 % de comptes rendus de congrès.
Plus de la moitié des contributions traitent de pathologie. Viennent ensuite la locomotion et médecine sportive (17 %), la reproduction (11 %). La nutrition et la génétique se partagent 9 % des contributions. Les autres thématiques définies en sciences du vivant sont le comportement et bien-être, les espèces asines et les équidés sauvages, le dopage. Environ 4 % des notices relèvent des sciences humaines et sociales.
L’Amérique du Nord et l’Union Européenne constituent les deux principaux pôles de recherche mondiaux avec 40 et 36 % des articles chacun. La France occupe la 7ème place (3,4 % des articles scientifiques) derrière les USA, le Royaume-Uni (12,5 %), l’Allemagne (6,3 %), le Japon (4,3 %), le Canada (3,8 %) et l’Australie (3,8 %). La France remonte à la 4ème place si l’on si l’on considère l’ensemble des articles. Ceci illustre l’importance de la littérature de transfert ou de comptes rendus de colloques.
La France apparaît relativement spécialisée sur la reproduction, le dopage et les sciences humaines et sociales, avec en revanche un investissement relatif moindre sur le comportement et la pathologie. La région Ile de France est la première région française en matière de recherche équine, avec 37,5 % des articles. Les autres régions importantes sont les régions Centre, Rhône-Alpes, Pays de la Loire, Midi-Pyrénées et Basse-Normandie. Cette atomisation géographique des équipes explique qu’aucune ville française ne figure parmi les 25 villes leaders.
Realistic Mathematic Education: a theoretical- methodological approach to the teaching of mathematics in countryside schools
Authors: Moura-Silva Marcos Guilherme , Souza Rayza de Oliveira , Goncalves Tadeu Oliver , Borges Ruy Guilherme Braga
Published: May 2020

The movement for a Rural Education still lacks investigations of methodological theoretical assumptions for the didactic field, based on the study of teaching practices that consider the object of knowledge and, at the same time, value the realistic/contextual aspect in which the student is inserted. From this perspective, we investigate the methodological theoretical implications of the theory of Realistic Mathematical Education (EMR) for the teaching of mathematics in the countryside school. Based on a qualitative methodological approach, a hypothetical learning path was elaborated based on the principles of EMR related to the teaching of analytical geometry, from the practice of soil modeling in passion fruit (passiflora edulis) cultivation. Our results point to the EMR as a promising methodological theoretical approach of didactic exploration to the countryside context capable of promoting formal reasoning, concepts in realistic situations, appropriation of mathematical language and potential for the development of concepts in the field of Cartesian geometry.
Recognition of Brahmi Words by Using Deep Convolutional Neural Network
Authors: Gautam Neha , Chai Soo See , Jose Jais
Published: May 2020

Significant progress has made in pattern recognition technology. However, one obstacle that has not yet overcome is the recognition of words in the Brahmi script, specifically the identification of characters, compound characters, and word. This study proposes the use of the deep convolutional neural network with dropout to recognize the Brahmi words. This study also proposed a DCNN for Brahmi word recognition and a series of experiments are performed on standard Brahmi dataset. The practical operation of this method was systematically tested on accessible Brahmi image database, achieving 92.47% recognition rate by CNN with dropout respectively which is among the best while comparing with the ones reported in the literature for the same task.
Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-enriched Subtypes
Authors: Jairath Neil K. , Farha Mark W. , Srinivasan Sudharsan , Jairath Ruple , Green Michael D. , Dess Robert T. , Jackson William C. , Weiner Adam B. , Schaeffer Edward M. , Zhao Shuang G. , Feng Felix Y. , El Naqa Issam , Spratt Daniel E.
Published: May 2020

Background: Prostate cancer (PCa) is characterized by significant heterogeneity in its molecular, genomic, and immunologic characteristics. Methods: Whole transcriptome RNAseq data from The Cancer Genome Atlas of prostate adenocarcinomas (n=496) was utilized. The immune microenvironment was characterized using the CIBERSORTX tool to identify immune cell type composition. Unsupervised hierarchical clustering was performed based on immune cell type content. Analyses of progression-free survival (PFS), distant metastases, and overall survival (OS) were performed using Kaplan-Meier estimates and Cox-regression multivariable analyses. Results: Four immune clusters were identified, largely defined by plasma cell, CD4+ Memory Resting T Cells (CD4 MR), M0 and M2 macrophage content (CD4 MRHighPlasma CellHighM0LowM2Low, CD4 MRLowPlasma CellHighM0LowM2Low, CD4 MRHighPlasma CellLowM0HighM2Low, and CD4 MRHighPlasma CellLowM0LowM2High). The two macrophage-enriched/plasma cell non-enriched clusters (3&4) demonstrated worse PFS (HR 2.24, 95% CI 1.46–3.45, p=0.0002) than the clusters 1&2. No metastatic events occurred in the non-macrophage-enriched clusters. Comparing clusters 3 vs 4, in patients treated by surgery alone, cluster 3 had zero progression events (p<0.0001). However, cluster 3 patients had worse outcomes after post-operative radiotherapy (p=0.018). Conclusion: Distinct tumor immune clusters with a macrophage-enriched phenotype and reduced plasma cell enrichment independently characterize an aggressive phenotype in localized prostate cancer that may differentially respond to treatment.
PENGUATAN SIKAP NASIONALISME MELALUI PEMBELAJARAN PENDIDIKAN KEWARGANEGARAAN PADA SEKOLAH INTERNASIONAL (Studi pada Secondary School di Singapore Piaget Academy Solo Raya)
Authors: Sari Eka , Ali Yusuf
Published: May 2020

The results of research are as follows: (1) the implementation of the reinforcement of nationalism attitudes through Civic Education learning on Secondary School at Singapore Piaget Academy of Solo Raya has run well through the phases of planning, implementation, and assesment as indicated in the learning process that the indicators of nationalism attitudes are always implanted to the learners’ minds, which includes: (a) Indonesian language, (b) knowledge of nationality, (c) domestic product consumption, (d) professionalism, (e) upholding unity and integrity, (g) giving priority to the public interest, (h) building of sense of brotherhood, and (i) participation; and (2) the constraints include substantial and technical ones. The former consist of the students’ low interest and the teacher’s low pedagogical competency. Meanwhile, the latter include the less time for the learning process.
Keywords : LNationalism, Civicl Education, Internationall School
PENGEMBANGAN INVOVASI PENDIDIKAN KOMUNIKASI MULTIKULTURAL MELALUI TAYANGAN RAGAM INDONESIA SEBAGAI STATEGI PENGUATAN IDENTITAS NASIONAL
Authors: Digdoyo Eko
Published: May 2020

The content of television as a public media broadcasts generally present news or social reality eventsyet it seems to be appropriate that the content must be received wisely andcritically. Receiving information without discretion will create a wrong and misleading image of the world, including an overview of multicultural education. Currently, mass media has a significant potential to instill prejudice between religions, cultures, and so on. The media in this case also has social responsibility to the public about the issues of freedom and protection of multicultural educationunderstanding. Therefore to support the theoretical approachof this study, theory about value of multicultural education whichisreinforcedby theory of social media responsibility was taken into account. The results showed thatRagam Indonesia as one of the television programs in Indonesia (in Trans 7) has been presenting shows that could be used as a good start to develop innovations in multicultural communication education, given the impressions of the content in Ragam Indonesia including the aspects of life; economics, religion, tradition, as well as local identities that can be wrapped into national identities as learning material for students, college students, and society. This kind of publication is considered to be very urgent in order to build national identity.
Key words: Inovation, Multicultural Education, Media, and National Identity
PERSEPSI MASYARAKAT ADAT KAMPUNG CIKONDANG DAN CIREUNDEU DALAM MEMAKNAI NILAI-NILAI KARAKTER BAGI SEORANG PEMIMPIN
Authors: Sukmayadi Trisna
Published: May 2020

Tujuan dari penelitian ini adalah untuk mengungkap persepsi masyarakat adat Kampung Cireundeu Kota Cimahi dan Cikondang Kabupaten Bandung dalam memaknai nilai-nilai karakter yang harus dipunyai oleh seorang pemimpin. Pendektan penelitian menggunakan kualitatif dengan jenis studi kasus. Teknik analisis data melalui studi liratur, wawancara mendalam, dan observasi, setelah dianalisis, kemudian dicocokan kebenarannya melalui triangulasi. Hasil penelitian menunjukan secara umum masyarakat adat berpersepsi bahwa nilai-nilai karakter yang harus dimiliki oleh seorang pemimpin di masyarakat adat Kampung Cireundeu dan Cikondang adalah nilai karakter religius, taat kepada adat dan tradisi leluhur, dan taat pada falsafah sunda, yakni silih asih, silih asah, dan silih asuh. Makna nilai-nilai karakter tersebut bagi masyarakat adat kampung Cireundeu dan Cikondang, yakni sebagai fondasi dalam membangun kehidupan masyarakat sesuai adat dan tradisi leluhur
Kata kunci: Persepsi, Masyarakat adat, Nilai Karakter
PENGARUH PENERAPAN MODEL PEMBELAJARAN VALUE CLARIFICATION TECHNIQUE TERHADAP CIVIC DISPOSITION SISWA KELAS XI SMA NEGERI 1 TERAS BOYOLALI TAHUN AJARAN 2016/2017
Authors: Aini Nur , Winarno Winarno , Nuryadi Muhammad Hendri
Published: May 2020

The objective of research was to find out whether or not there is an effect of value clarification technique learning model application on civic disposition in the 11th graders of SMA Negeri 1 Teras Boyolali in the school year of 2016/2017. This study was an experimental quantitative research. The research design was true experimental design with posttest only control design model. The population of research was the 11th graders of SMA Negeri 1 Teras Boyolali in the school year of 2016/2017. The sampling technique used was cluster random sampling. The sample of research consisted of 68 students: 34 in experimental and 34 in control groups. Data collection in this research was carried out using observation and questionnaire. Data validation for the students’ civic disposition questionnaire in basic competency of conceiving various effects and threats against the state in maintaining Bhinneka Tunggal Ika was carried out using validity and reliability test. To find out whether or not the items of question were valid, Pearson’s product moment correlational formula was used. Meanwhile, the reliability used in this research was Alpha Cronbach. Technique of analyzing data used was a two-independent sample t test.

Considering the research an average score of 86,03 experimental class is higher than he average score of 80,76 control class. Then the hypothesis testing using a two independent sample t test with t statistic > t tabel 13,560 > 1,997 at significance level of 5% means that there are difference of  civic disposition between the students in experiment and those in control classes. So that from the result it could be found that there was an effect of value clarification technique learning model on the students’ civic disposition in basic competency of conceiving various effects and threats against the state in maintaining Bhinneka Tunggal Ika in the 11th graders of SMA Negeri 1 Teras Boyolali in the School Year of 2016/2017.

 
Keywords: Value Clarification Technique, Civic Disposition
PENGUATAN NILAI-NILAI TOLERANSI OLEH MAJLIS TAFSIR AL QUR’AN (MTA) PUSAT SEBAGAI UPAYA MENJAGA KERUKUNAN ANTAR UMAT BERAGAMA DI KOTA SURAKARTA
Authors: Setiawan Diky , Permata Hartanto Rima Vien , Muchtarom Mohammad
Published: May 2020

The purpose of this study are 1) to describe the implementation of strengthening tolerance values by Majlis Tafsir Al Qur'an (MTA) Center, 2) to describe the impact of strengthening the tolerance values by Majlis Tafsir Al Qur'an (MTA), 3) to know the supporting factors and the inhibitors of strengthening tolerance value by Majlis Tafsir Al Qur'an (MTA) as an effort to maintain the harmony between one and another religious groups. This study uses a qualitative research approach, this type of research is described qualitatively. The data sources are obtained from informants, places, events, and documents. Based on the results of this study, it can be concluded that (1) The implementation of strengthening tolerance values by Majlis Tafsir Al Qur'an (MTA) Center is carried out through recitation and activities in various fields such as: education, social, and health, which contain values the value of respecting, respecting, accepting differences, and mutual cooperation based on the Qur'an and the Sunnah, (2) The harmony between religious communities in the society is always guarded by Majlis Tafsir Al Qur'an (MTA), this is evidenced in the research findings where there is good relations between the congregation of the MTA and non-Muslim citizens around MTA, (3) The supporting factors of the strengthening of tolerance values in the Majlis Tafsir Al Qur'an (MTA) are: the value of tolerance in the Qur'an and the Sunnah (the Prophet's hadith) in the teachings of Islam, facilitates the strengthening of tolerance values that can be accepted by the congregation, the teaching material is conveyed in a language that is easily understood by worshipers, and the understanding of tolerance in MTA is relatively high. The inhibiting factors are: there is no study material that specifically made to discuss about the values of tolerance, the existence of a society that is easily provoked by issues and slander that develops so that it prevents MTA activities, and there are some individuals (Ex MTA) who vilify MTA. Key words: Strengthening The Tolerance Value, The Harmony Between Religious Communities, Majlis Tafsir Al Qur’an (MTA) Center
STUDI RELEVANSI MODEL PEMBELAJARAN YANG DIGUNAKAN GURU DENGAN KOMPETENSI DASAR PADA MATA PELAJARAN PENDIDIKAN KEWARGANEGARAAN
Authors: Prasetya Bayu Yoga , Rasyid Machmud Al , Wijianto Wijianto
Published: May 2020

The aims of this study are: 1) Describe the learning models used by the teachers on Citizenship Education subject. 2) Explain the relevance of the learning models used with the basic competencies in Citizenship Education subject. According to the results of the study, there are two conclusions. The first one is the teachers use a few learning models in Citizenship Education. The first model is the class based-passive cognitive pedagogies model. The teacher has planned the subject as stated in the lesson plan (RPP). This model emphasizes traditional learning about how the teacher provides initial definitions, principles, and concepts of learning materials and provides examples of problem-solving exercises in the form of lectures, demonstrations, question and answer, and assignments. The second model is the application of the model used by the teacher, namely lectures. The second conclusion is, the learning model used by the teachers in Wikarya Vocational School is not yet relevant to the basic competencies in the school. This can be seen from a number of facts, namely: a) the plan for implementing learning that has been prepared by the teacher does not fully reflect the circumstances during the learning process. b) The teachers do not apply everything contained in the lesson plan and the teachers still use the traditional learning models which is the lecture model. c) On average more than 70% of students have low minimum completeness criteria. d) Attitudes and behaviors of the students in the school show the lack of achievement of basic competencies to be achieved. In addition to the facts mentioned above, the unsuccessful learning model applied by the teachers at Karanganyar Wikarya Vocational School in maintaining a conducive atmosphere during the learning process makes the students feel bored and not concerned with the importance of the lesson. Then, it results in failure to achieve the expected basic competencies. Keywords : learning model, teacher, basic competence
Angiogenesis in Patients with Chronic Heart Failure: Focus on Endothelial Vascular Growth Factor, Pentraxin-3 and Transforming Growth Factor Beta
Authors: Shepel R. N. , Drapkina O. M.
Published: May 2020

Chronic heart failure (CHF) is considered the leading cause of death in patients with established cardiovascular (CVD) and metabolic diseases. Although the current treatment strategy has improved survival and clinical outcomes, the prevalence of CHF shows an increase. Current clinical guidelines for the treatment and prevention of CVD note the role of biological markers as a fairly simple and powerful tool for diagnosing, stratifying risk and predicting CHF. However, it is unclear whether all of these biological markers are equally capable of predicting cardiovascular mortality and heart failure related outcomes in patients with acute and chronic heart failure, as well as in different phenotypes of heart failure. However, the results of numerous studies demonstrate scientific interest in the processes of angiogenesis among patients with CHF. There is an impressive body of evidence linking CHF to the level of markers such as vascular endothelial growth factor, pentraxin-3, and transforming growth factor beta. The review presents the data of domestic and foreign clinical studies devoted to the study of the level of angiogenesis markers among patients with CHF.
1 Protecting the Hearing of Performing Artists
Authors: Manchester Ralph A
Published: May 2020

While there are many causes of hearing loss, many of which have nothing to do with exposure to loud noises, noise (or music)-induced hearing loss is theoretically preventable 100% of the time. Loss of hearing is typically a major problem if it happens to dancers and actors, but it is
catastrophic for musicians. Thus, it is not surprising that this topic has been covered extensively in Medical Problems of Performing Artists, starting with “The Musician and Occupational Sound Hazards” by Hart et al. in volume 2, over 20 years ago. Without duplicating the content
of those articles, this editorial will try to determine why this remains a somewhat controversial topic in the performing arts and what can be done to move us forward.
Self-Reported and Reported Injury Patterns in Contemporary Dance Students
Authors: Baker Jo , Scott Daniel , Watkins Katherine , Keegan-Turcotte Sheramy , Wyon Matthew
Published: May 2020

BACKGROUND: Injury is a major concern among dancers, as currently rates are reported as being high. The purpose of the present study was to assess the incidence and details of injuries across an academic year at a full-time contemporary dance school. METHODS: A questionnaire was distributed
to 57 dancers at the end of their first academic year. Reported injury information was also retrieved from a database as collected from a physiotherapist over the same period. RESULTS: Differences were found between the reported and self-reported information, particularly with reference to
shin injuries. The majority of injuries occurred in November and May, noted to be close to assessment periods. CONCLUSION: Injury rates in contemporary dance are high; notably, 89% of dancers reported one or more injuries. This problem is particularly evident in the lower limb.
Cardiac Response During Trumpet Playing
Authors: Robertson Donald U , Federoff Lynda , Eisensmith Keith E
Published: May 2020

Heart rate, heart rate variability, stroke volume, and cardiac output were measured while six college students and six professionals played trumpet. One-minute rest periods were followed by 1 minute of playing exercises designed to assess the effects of pitch and articulation. Heart
rate and heart rate variability increased during playing, but stroke volume decreased. Changes in heart rate between resting and playing were greater for students, although beat-to-beat variability was larger for professionals in the upper register. These results suggest that expertise is
characterized by greater physiological efficiency.
A Prisoner’s Dilemma with Asymmetrical Payoffs: Revealing the Challenges Faced by Performing Arts Health and Wellness Practitioners
Authors: Shan Gongbing , Visentin Peter
Published: May 2020

In a prisoner’s dilemma, constructed narratives are used to demonstrate problems within individual rationality and decision-making. Performing artists can be seen as facing a type of prisoner’s dilemma in their careers: they must practice repeated movements for long periods
in order to improve, yet despite the short-term perception of gained artistic benefit, the long-term consequences may be playing-related musculoskeletal disorders and injury. To help avoid such an outcome, educators and health and wellness practitioners must function as negotiators, engaging
in discussions of artistry as part of establishing credibility and encouraging behaviors that keep artists in efficient, healthy behaviors. By setting practice time limits that are considerate of the intensity of each specific task, performers can improve their performance on a daily basis
and become more skilled at planning their future training.
Facies heterogeneity and source potential of carbonate-mudstone-dominated distal ramp deposits, Agrio Formation, Neuquén Basin, Argentina
Authors: Moore Shawn A. , Birgenheier Lauren P. , Greb Matthias D. , Minisini Daniel , Tunik Maísa , Omarini Julieta
Published: May 2020

The carbonate-mudstone-dominated Lower Cretaceous Agrio Formation is the youngest marine source rock of the hydrocarbon-prolific Neuquén Basin in Argentina, yet its facies variability and unconventional hydrocarbon potential remains relatively understudied. Detailed studies of mudstone facies variability in thick, carbonate mudstone successions deposited largely below storm wave base (i.e., chalk–marl, black shale, limestone), like the Agrio Formation, are rare and instead commonly focus on biostratigraphy or organic geochemistry alone. A continuous northern section of the Agrio Formation and a southern composite section of the lower Pilmatué and middle Avilé members, totaling ∼ 1,200 m of outcrop, were measured. From these measured sections, programmed pyrolysis (n = 339 samples), X-ray diffraction (XRD; n = 69), and thin sections (n = 69) were used to develop a high-resolution integrated macrofacies and microfacies scheme. The four most volumetrically abundant facies include detrital-quartz-silt-bearing fine mudstone (facies 1), radiolarian-bearing calcareous fine mudstone (facies 2), detrital-quartz-silt- and shell-bearing calcareous fine mudstone (facies 3), and calcareous wackestone (facies 4). All four facies are volumetrically dominated by carbonate mud matrix (i.e., micrite) that represents either 1) original pelagic coccolithophore deposition modified by diagenesis, 2) transported carbonate mud (i.e., bottom currents like contour currents or sediment gravity flows), or 3) a combination of both. Outcrop observations, XRD mineralogic trends, and petrographic variations in grain composition between detrital quartz silt, radiolarian and microfossil to macrofossil content (mainly benthic foraminifera and bivalves) distinguish the four mudstone facies. The facies scheme indicates distinctly more heterogeneous and current-influenced sedimentation in the downdip sub-storm wave base than previously described in the Agrio and in carbonate-dominated basinal settings in general. A depositional model is proposed for further testing that may prove valuable towards re-evaluating basinal carbonate mudstone successions worldwide. Utilizing TOC, S2, and HI value cutoffs, this study defines five discrete stratigraphic packages in the Agrio Formation that have the highest source potential, collectively totaling ∼ 140 m thick. The novel integration of macrofacies and microfacies analysis, stratigraphy, and a geochemical analysis allow both depositional insights and the assessment of a potential source rock. The study adds to a growing body of literature on 1) carbonate ramp (or slope) to basinal processes and 2) facies models for organic-rich, carbonate-dominated mudstone successions that are unconventional hydrocarbon systems.
Predictive risk score model for severe fever with thrombocytopenia syndrome mortality based on qSOFA and SIRS scoring system
Authors: Wang Li , Zou Zhiqiang , Ding Kun , Hou Chunguo , Qin Song
Published: May 2020

Background: Severe fever with thrombocytopenia syndrome (SFTS) is a severe systemic virus infectious disease usually having multi-organ dysfunction which resembles sepsis. Methods: Data of 321 patients with laboratory-confirmed SFTS from May 2013 to July 2017 were retrospectively analyzed. Demographic and clinical characteristics, calculated quick sequential organ failure assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria for survivors and nonsurvivors were compared. Independent risk factors associated with in-hospital mortality were obtained using multivariable logistic regression analysis. Risk score models containing different risk factors for mortality in stratified patients were established whose predictive values were evaluated using the area under ROC curve (AUC). Results: Of 321 patients, 87 died (27.1%). Age ( p <0.001) and percentage numbers of patients with qSOFA≥2 and SIRS≥2 ( p <0.0001) were profoundly greater in nonsurvivors than in survivors. Age, qSOFA, SIRS score and aspartate aminotransferase (AST) were independent risk factors for mortality for all patients. And qSOFA score was the only common risk factor in all patients, those age≥60 years and those enrolled in the intensive care unit (ICU). A risk score model containing all these risk factors (Model1) has high predictive value for in-hospital mortality in these three groups with AUCs (95% CI): 0.919 (0.883-0.946), 0.929 (0.862-0.944) and 0.815 (0.710-0.894), respectively. A model only including age and qSOFA also has high predictive value for mortality in these groups with AUCs (95% CI): 0.872 (0.830-0.906), 0.885(0.801-0.900) and 0.865 (0.767-0.932), respectively. Conclusions: Risk models containing qSOFA have high predictive validity for SFTS mortality.
Cohort Profile: The Nigerian HIV Geriatric Cohort Study
Authors: Dakum Patrick , Avong Yohanna Kambai , Odutola Michael Kolawole , Okuma James , Kayode Gbenga Ayodele , Nta Iboro Ekpo , Ndembi Nicaise , Mensah Charles , Khamofu Hadiza , Okonkwo Prosper , Okpanachi John Oko , Ezeanolue Echezona
Published: May 2020

Background: The Nigerian HIV Geriatric Cohort (NHGC) is a longitudinal cohort setup to learn how elderly people living with HIV (EPLHIV) in Nigeria fare, despite not being prioritized by the national treatment program, and to deepen knowledge for their differentiated care and achieve better outcomes. In this paper, we describe data collected on sociodemographic and clinical data from EPLHIV from the inception of Nigeria’s national HIV program to 2018. Methods: Patient-level data spanning the period 2004 to 2018, obtained from comprehensive HIV treatment hospitals, that are supported by four major PEPFAR-implementing partners in Nigeria were used. These 4 entities collaborated as member organizations of the Nigeria Implementation Science Alliance. We defined elderly as those aged 50 years and above. From deidentified treatment records, demographic and clinical data of EPLHIV ≥50-year-old at ART initiation during the review period was extracted, merged into a single REDcap® database, and described using STATA 13. Results: A total of 101,652 unique EPLHIV entries were analysed. This cohort’s data was of 53,608(52.7%) women, 51,037(71.4%) of EPLHIV identified as married and 33,446(51.1%) unemployed. Mean age was 57.1 years (SD=6.9) with average duration on ART as 4.6 years (SD=3.5). ART profile showed that 88,792(95.7%) were on 1st-line and 55,905 (64.9%) were on TDF-based regimens. Mean-body mass index (BMI) was 23.0 kg/m2 (SD=5.4 kg/m2) with 56,010(55.1%), 19,619(19.3%) and 8844(8.7%) showing normal (18.5kg/m2–24.9kg/m2), overweight (BMI 25 -<30kg/m2) and obese (BMI ≥30kg/m2) ranges respectively. prevalence of hypertension (systolic-BP >140mmHg or diastolic-BP >90mmHg) was 21,550(21.2%) EPLHIV records. Mean CD4 count was 420cells/μL (SD=285cells/μL) and 83,660(82.3%) had a viral load result showing <1000copies/ml. As for treatment outcomes, available records showed that 54.1% were active-in-treatment, 28.4% were lost-to-follow-up and 6.8% died. Poor population death records and aversion to autopsies makes it almost impossible to estimate AIDS-related deaths. Conclusions: This cohort describes the clinical and non-clinical profile of EPLHIV in Nigeria. We are following up the cohort to design and implement intervention programs, develop prognostic models to achieve better care outcomes for EPLHIV. This cohort would provide vital information for stakeholders in HIV prevention, care and treatment to understand the characteristics of EPLHIV.
Serum amyloid a, a potential biomarker both in serum and tissue, correlates with ovarian cancer progression
Authors: Li Ze , Hou Yongwang , Zhao Meng , Li Tianning , Liu YaHui , Chang Jiao , Ren Li
Published: May 2020

Background: Ovarian cancer is the most fatal gynecologic malignancy worldwide due to its vagueness, delay in diagnosis, recurrence, and drug resistance. Therefore, a new type of ovarian cancer treatment prediction biomarker is urgently needed to supplement existing tools. A total of 230 people participated in this study. Out of this figure, 100 participants were patients who underwent an ovarian tumor operation, another 100 participants were ovarian benign patients, and the remaining 30 participants were healthy women. Cancer (experimental) group were 100 patients who underwent ovarian tumor operation, while the control groups were 130 participants consisting of 100 ovarian benign patients and 30 healthy women. Levels of SAA, carbohydrate antigen-125 (CA-125), and human epididymis protein 4 (HE4) were assessed using standard laboratory protocols. A total of 5 ovarian cancer tissues and paracancerous tissues were collected and then stored at − 80℃ until the qRT-PCR assay was conducted. Results: The ROC curve of SAA concentration in ovarian cancer was plotted to obtain the area under the curve AUC = 0.889, the cut-off value 17.05 mg/L, the sensitivity 78.4% and specificity 86.5%. Compared with pretreatment, the level of serum SAA decreased significantly after treatment. The results revealed that there was a significant correlation between the level of serum SAA and advanced FIGO stage, histology subtype, lymphatic invasion, and distant metastasis (p = 0.003,0.002,0.000 and 0.001). The quantitative Reverse transcription polymerase chain reaction (qRT-PCR) assay revealed that the Messenger RNA (mRNA) of SAA-1 and SAA-4 was much higher in cancer tissues than in adjacent tissues, and MMPs was up-regulation including MMP-1, MMP-9 and MMP- 12 in OVCAR-3 cell stimulated by SAA. The transwell assay revealed that SAA could promote OVCAR-3 cell migration. Moreover, SAA can regulate EMT markers and promote AKT pathway activation. Conclusions: In summary, our results demonstrated that SAA may be a potential diagnosis and treatment prediction biomarker. The SAA promotes OVCAR-3 cell migration by regulating MMPs and EMT which may correlate with AKT pathway activation.
Neuroprotective Effects of Magnesium L-threonate in a Hypoxic Zebrafish Model
Authors: Kim Young Sung , Won Young Ju , Lim Byung Gun , Min Too Jae , Kim Yeon-Hwa , Lee Il-Ok
Published: May 2020

Background: Hypoxia inhibits the uptake of glutamate (a major neurotransmitter in the brain closely related to cognitive function) into brain cells, and the initial response of cells to cortical hypoxia depends on glutamate. Previous studies have suggested that magnesium may have protective effects against hypoxic injuries. In particular, magnesium L-threonate (MgT) may increase magnesium ion concentrations in the brain better than MgSO 4 and improve cognitive function.Methods: We evaluated cell viability under hypoxic conditions in the MgT- and MgSO 4 -treated human SH-SY5Y neurons, in vivo behavior using the T-maze test following hypoxia in MgT-treated zebrafish, activity of brain mitochondrial dehydrogenase by 2,3,5-triphenyltetrazolium chloride (TTC) staining, and protein expression of the excitatory amino acid transporter (EAAT) 4 glutamate transporter by western blotting.Results : Among the groups treated with hypoxia, cell viability significantly increased when pre-treated with 1 or 10 mM MgT (p = 0.009 and 0.026, respectively) Despite hypoxic insult, MgT-treated zebrafish showed preferences for the red compartment (p= 0.025 for distance and p= 0.007 for frequency of entries), suggesting memory preservation. TTC staining showed reduced cerebral infarction and preserved absorbance in the MgT-treated zebrafish brain after hypoxia (p=0.010 compared to the hypoxia group). In addition, western blot showed upregulation of EAAT4 protein in the MgT treated group.Conclusions: Pre-treatment with MgT attenuated cell death and cerebral infarction due to hypoxia and protected cognitive function in zebrafish. In addition, MgT appeared to modulate expression of the glutamate transporter, EAAT4.
GLV-1h68 vaccinia virus therapy of neuroendocrine neoplasms
Authors: Kloker Linus D , Berchtold Susanne , Smirnow Irina , Beil Julia , Krieg Andreas , Sipos Bence , Lauer Ulrich M
Published: May 2020

Background: Oncolytic virotherapy is an upcoming treatment option for many tumor entities. But so far, a first oncolytic virus only was approved for advanced stages of malignant melanomas. Neuroendocrine tumors (NETs) constitute a heterogenous group of tumors arising from the neuroendocrine system at diverse anatomic sites. Due to often slow growth rates and (in most cases) endocrine non-functionality, NETs are often detected only in a progressed metastatic situation, where therapy options are still severely limited. So far, immunotherapies and especially immunovirotherapies are not established as novel treatment modalities for NETs.Methods: In this immunovirotherapy study, pancreatic NET (BON-1, QGP-1), lung NET (H727, UMC-11), as well as neuroendocrine carcinoma (NEC) cell lines (HROC-57, NEC-DUE1) were employed. The well characterized genetically engineered vaccinia virus GLV-1h68, which has already been investigated in various clinical trials, was chosen as virotherapeutical treatment modality. Results: Profound oncolytic efficiencies were found for NET/NEC tumor cells. Besides, NET/NEC tumor cell bound expression of GLV-1h68-encoded marker genes was observed also. Furthermore, a highly efficient production of viral progenies was detected by sequential virus quantifications. Moreover, the mTOR inhibitor everolimus, licensed for treatment of metastatic NETs, was not found to interfere with GLV-1h68 replication, making a combinatorial treatment of both feasible. Conclusions: In summary, the oncolytic vaccinia virus GLV-1h68 was found to exhibit promising antitumoral activities, replication capacities and a potential for future combinatorial approaches. This has been shown in a widespread spectrum of cancers in a preclinical setting and now has to be further evaluated for treatment of metastatic neuroendocrine cancer.
The role of a 3D printed model in the teaching of human anatomy: a meta-analysis
Authors: Ye Zhen , Jiang Hanming , Nie Cuifang , Zhao Shulian , Wang Tao , Dun Aishe , Zhai Jing
Published: May 2020

Background: Three-dimensional (3D) printing is an emerging technology widely used in medical education . However, its role in the teaching of human anatomy needs further evaluation. This st udy compared 3D printed models with conventional models to provide a better understanding of their use in the teaching of anatomy. Methods: PubMed, Embase, EBSCO, SpringerLink, and Nature databases were searched systematically for studies published up to April 2020 in the English language. This study complies with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. In this study, a meta-analysis of continuous and binary data was carried out. Both descriptive and statistical analysis were adopted. Results: In the teaching of human anatomy, compared with students in the conventional group, those in the 3D printing group showed several advantages in performance testing, time consumption, students’ intention, and usefulness. The leave-one-out method further confirmed the stability of the results. Conclusions: Compared with students in the conventional group, those in the 3D printing group had advantages in answering accuracy and answering time. In the test of anatomical knowledge, the test results of students in the 3D group were not inferior to those in the traditional group. Results of the autopsy test in the 3D group were better than those in the cadaver or 2D group. More students in the 3D printing group were satisfied with their learning compared with students in the conventional group. The results were influenced by the quality of randomized controlled trials. In the framework of abiding by ethics, the application of the 3D printing model in human anatomy teaching is worthy of expectation.
Stigma for Common Mental Disorders in Racial Minorities and Majorities A Systematic Review and Meta-Analysis
Authors: Eylem Ozlem , de Wit Leonore , straten Annemieke van , Steubl Lena , Melissourgaki Zaneta , Danışman Gözde Topgüloğlu , de Vries Ralph , Kerkhof Ad J.F.M , Bhui Kamaldeep , Cuijpers Pim
Published: May 2020

Background There is a strong stigma attached to mental disorders preventing those affected from getting psychological help. The consequences of stigma are worse for racial and/or ethnic minorities compared to racial and/or ethnic majorities since the former often experience other social adversities such as poverty and discrimination within policies and institutions. This is the first systematic review and meta-analysis summarizing the evidence on the impact of differences in mental illness stigma between racial minorities and majorities. Methods This systematic review and meta-analysis included cross-sectional studies comparing mental illness stigma between racial minorities and majorities. Systematic searches were conducted in the bibliographic databases of PubMed, PsycINFO and EMBASE until 20 th December 2018. Outcomes were extracted from published reports, and meta-analyses, and meta-regression analyses were conducted in CMA software. Results After screening 2,787 abstracts, 29 studies with 193,418 participants (N=35,836 in racial minorities) were eligible for analyses. Racial minorities showed more stigma than racial majorities (g=0.20 (95% CI: 0.12~0.27) for common mental disorders. Sensitivity analyses showed robustness of these results. Multivariate meta-regression analyses pointed to the possible moderating role of the number of studies with high risk of bias on the effect size. Racial minorities have more stigma for common mental disorders when compared with majorities. Limitations included moderate to high risk of bias, high heterogeneity, few studies in most comparisons, and the use of non-standardized outcome measures. Conclusions Mental illness stigma is higher among ethnic minorities than majorities. An important clinical implication of these findings would be to tailor anti-stigma strategies related with mental illnesses according to specific racial and/or ethnic backgrounds with the intention to improve mental health outreach.
Use of profession-role exchange in an interprofessional student team-based community health service-learning experience
Authors: Wang Jun , Guo Jie , Wang Yubin , Yan Dan , Liu Juan , Zhang Yinghong , Hu Xianmin
Published: May 2020

Background During interprofessional clinical practice, compared to understanding of one’s own professional role and function, it might be more difficult to clarify the roles and contributions of the other health-care team members because of the inter-professional barrier. In order to provide students the opportunity for real experience with other professions in team environments and enhance their perceptions of other professions’ roles, this study developed a comprehensive and multi-dimension extracurricular interprofessional education (IPE) model through designing and integrating a profession-role exchange component, that was medical students as pharmacists or nurses, pharmacy students as physicians or nurses, and nursing students as physicians or pharmacists in the interprofessional health-care student team, into the service learning experience in a real community setting. Methods In this pre/post-intervention study, the effect of integrated profession-role exchange experiences on the students’ attitudes towards interprofessional collaboration and their role clarification was evaluated among 60 student volunteers (20 medical students, 20 pharmacy students and 20 nursing students). All involved students were divided into the profession-role exchange intervention group and the control group. Subjects in the control group did not participate the profession-role exchange experiences, the other IPE procedures were the same for both groups. Three survey instruments for attitudes toward interprofessional clinical collaboration were respectively used to measure the students’ attitudes toward physician-pharmacist, physician-nurse and nurse-pharmacist collaborations. “Roles and responsibilities” subscale of Readiness for Interprofessional Learning Scale was used to evaluate the overall role clarification during IPE Results Compared to the control IPE activity, the addition of profession-role exchange component resulted in the significant increase in students’ positive attitudes towards interprofessional collaboration, and the enhancement of students’ role awareness. Conclusions The profession-role exchange might be more effective and better initiate students to the practice of interprofessional collaboration, and could be used as an effective IPE tool for improving the role awareness of health-care students.