bluuebunny/crossref_metadata_2025 huggingface dataset:
Gayl Jones's Afro-Brazil: Hemispheric Black Feminisms and (Mis)Readings of Marronage
Authors: Osei Cassie , Mundell John A.
Published: December 2024

Abstract: This article considers Gayl Jones's interventions as a counter-storyteller of Black Brazilian history, focusing on her narrative-poem Song for Anninho (1981) and novel Palmares (2021). Highlighting in each the history of the Palmares quilombo , or maroon community, through the eyes of Almeyda, a Black woman, Jones features marronage as an act of resistance to enslavement as well as a radical Black tradition through which she can critique the white historical and literary canon in the Americas. These questions surrounding Black women's fugitivity put Jones directly in hemispheric conversation with Lélia Gonzalez (1935–94) and Beatriz Nascimento (1942–95), pioneers in Black Brazilian feminist theory. Jones, Gonzalez, and Nascimento understand orality as critical to Black resistance through storytelling, language, and knowledge production. As each offer readings of Black Brazilian history, the mis-readings—misrepresentations of Black women by the archive and what Black women purposefully obscure—are potential risks taken to resist archival silences.
CubEd: a 3D printable fluorescence cube microscope optimized for classroom and teaching use
Authors: Tourtellotte Jocelyn , Hammer Mathias , Hormann Colton , Flemming Selene , Tran Brian , Rong Hui , Grunwald David
Published: December 2024

“When all you have is a hammer, everything is a nail” diametrically opposes the “right tool for the job” mentality. After observing graduate students in the biological sciences often adopting the former approach towards fluorescence light microscopy – using religiously the closest available microscope rather than the most suitable on campus – we endeavored to shift mentality towards the latter through teaching how the tools work. We further observed that these students often lack an understanding of optics. To instill a practical knowledge of optics as applied in fluorescence microscopy, we set about to create an educational experience that linked theory and practice. As part of this effort, we provided students an opportunity to construct fluorescence microscopes in an open-ended, stepwise fashion with built-in features, such as the ability to track the beam along the beam path. As a result, we developed the CubEd, an easy-to-use, inexpensive, and extensible optics system that may lead students to a better understanding of how fluorescence microscopy works, and, as a result, will enable them to better design their own experiments in the future. This requires replacing expensive, closed system, boxed commercial microscopes with a modular, open frame system that allows direct access to the optics. Based on an early iteration of the UC2 microscope, the CubEd was conceived. It is an open-source microscope of modular design that balances cost, ease-of-use, flexibility of design, and extensibility.
Volumetric Reconstruction for Improved 3D Single-Molecule Localisation Microscopy
Authors: Harvey Andrew , Olesker Daniel , Taylor Jonathan , Handley Michael
Published: December 2024

Localisation microscopy provides a dramatic resolution enhancement over conventional microscopy, capable of imaging biological structures at the scale of individual molecules. The image-acquisition speed is however limited by the requirement to time-sequentially image individual fluorescence emissions without significant overlap of the emitter images. For 3D localisation microscopy, each emission is encoded with a spatially extended 3D point-spread function, which further reduces the maximum usable density of emitters in acquired images, and increases the time required to construct a single 3D image. We report a new volumetric localisation microscopy technique that directly deconvolves a single 2D recorded image into a 3D volumetric reconstruction of compact emitter images. Importantly, this enables the domain for detection and fitting of emitter images to be shifted from the acquired, relatively cluttered 2D images to the relatively uncluttered and sparse reconstructed 3D volume.
Multiomic profiling of chronically activated CD4+ T cells identifies drivers of exhaustion and metabolic reprogramming
Authors: Lawton Matthew L. , Inge Melissa M. , Blum Benjamin C. , Smith-Mahoney Erika L. , Bolzan Dante , Lin Weiwei , McConney Christina , Porter Jacob , Moore Jarrod , Youssef Ahmed , Tharani Yashasvi , Varelas Xaralabos , Denis Gerald V. , Wong Wilson W. , Padhorny Dzmitry , Kozakov Dima , Siggers Trevor , Wuchty Stefan , Snyder-Cappione Jennifer , Emili Andrew
Published: December 2024

Repeated antigen exposure leads to T-cell exhaustion, a transcriptionally and epigenetically distinct cellular state marked by loss of effector functions (e.g., cytotoxicity, cytokine production/release), up-regulation of inhibitory receptors (e.g., PD-1), and reduced proliferative capacity. Molecular pathways underlying T-cell exhaustion have been defined for CD8+ cytotoxic T cells, but which factors drive exhaustion in CD4+ T cells, that are also required for an effective immune response against a tumor or infection, remains unclear. Here, we utilize quantitative proteomic, phosphoproteomic, and metabolomic analyses to characterize the molecular basis of the dysfunctional cell state induced by chronic stimulation of CD4+ memory T cells. We identified a dynamic response encompassing both known and novel up-regulated cell surface receptors, as well as dozens of unexpected transcriptional regulators. Integrated causal network analysis of our combined data predicts the histone acetyltransferase p300 as a driver of aspects of this phenotype following chronic stimulation, which we confirmed via targeted small molecule inhibition. While our integrative analysis also revealed large-scale metabolic reprogramming, our independent investigation confirmed a global remodeling away from glycolysis to a dysfunctional fatty acid oxidation-based metabolism coincident with oxidative stress. Overall, these data provide both insights into the mechanistic basis of CD4+ T-cell exhaustion and serve as a valuable resource for future interventional studies aimed at modulating T-cell dysfunction.
Maternal lipid mobilization is essential for embryonic development in the malaria vector Anopheles gambiae
Authors: Itoe Maurice A. , Shaw W. Robert , Stryapunina Iryna , Vidoudez Charles , Peng Duo , Du Esrah W. , Rinvee Tasneem A. , Singh Naresh , Yan Yan , Hulai Oleksandr , Thornburg Kate E. , Catteruccia Flaminia
Published: December 2024

Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we show that impairing lipolysis in Anopheles gambiae, the major malaria vector, leads to embryonic lethality. Embryos derived from females in which we silenced the triglyceride lipase AgTL2 or the lipid storage droplet AgLSD1 develop normally during early embryogenesis but fail to hatch due to severely impaired metabolism. Embryonic lethality is efficiently recapitulated by exposing adult females to broad-spectrum lipase inhibitors prior to blood feeding, unveiling lipolysis as a potential target for inducing mosquito sterility. Our findings provide mechanistic insights into the importance of maternal lipid mobilization in embryonic health that may inform studies on human reproduction.
Effects of horticultural therapy versus handiwork on anterior cingulate cortex activity in people with chronic low back pain: A randomized, controlled, cross-over, pilot study
Authors: Rören Alexandra , Debacker Clement , Saghiah Marc , Bedin Catherine , Fayolle Anna , Abdoul Hendy , Lefèvre-Colau Marie-Martine , Rannou François , Oppenheim Catherine , Nguyen Christelle
Published: December 2024

To assess the efficacy of horticultural therapy (HT) on anterior cingulate cortex (ACC) activity and the changes in rumination and catastrophizing scores in individuals with chronic low back pain (LBP). We conducted a randomized, controlled, cross-over, 3-week pilot study (ClinicalTrials.gov Identifier: NCT04656158). The departments of physical medicine and rehabilitation (hospital grounds and occupational therapy room) and imaging research were involved. The participants were adults with non-specific chronic LBP. All participants underwent two 90-min HT sessions and two 90-min handiwork sessions per week. The activity sequence order was randomized, and the activities were separated by a wash-out period of 1 week. Each participant underwent 3 brain MRIs: before, after the first, and after the second activity. The primary outcome was the change in ACC perfusion in ml/100g/min using arterial spin labeling MRI. The secondary outcomes were the changes in self-reported rumination and catastrophizing scores after each activity compared to baseline. Sixteen participants were included: 14 women (87.5%), LBP intensity (numeric rating scale) mean (SD) 45.1 (27.2)/100, specific activity limitation (Roland Morris disability questionnaire) 9.3 (4.1)/24. Change in ACC perfusion from baseline was -0.1 (10.7), 95% CI [-5.6, 5.8] ml (blood)/100g (tissue)/min after handiwork and -0.1 (8.7), [-4.7, 4.6] after HT and did not differ between the 2 activities (p = 0.91). Change in rumination [-0.5 (4.4) after handiwork and -0.3 (2.8) after HT] and catastrophizing scores [-2 (2.8) after handiwork and -1.4 (2.3) after HT] did not differ between activities (p = 0.99 and 0.22, respectively). Limited exposure to the interventions and the sample profile (moderate levels of pain) may explain our results. Our results highlight the need for future studies using the most appropriate outcomes to determine the exact effects of nature experiences in people with chronic musculoskeletal disease.
Dynamic pricing optimization for high-speed railway based on passenger flow assignment
Authors: CAO Jiren , NIE Lei , TONG Lu , HE Zhenhuan , LIU Zhangjiaxuan
Published: December 2024

In order to improve the operation efficiency and market competitiveness, how to optimize the ticket pricing strategy of high-speed railway to match the dynamic supply-demand relationship was an urgent problem to be studied. Taking differentiated passenger demand and supply trains as the research object, the space-time service network based on train timetable was constructed. The generalized cost formula and travel utility formula of passenger travel were proposed, which contained economy, rapidity, convenience, comfort, and route correlation cost. A multi-objective dynamic pricing model was proposed. The model aimed at maximize the corporate revenue and maximize passenger travel benefit, and was solved by large neighborhood search heuristic algorithm and path size logit assignment based on capacity constraint-passenger flow increment accurate algorithm. Based on real data, the Shandong circular high-speed railway case compared the average total revenue under different ticket price adjustment ranges and the ticket price for different classes of trains under different OD levels. The case proved the practicability of dynamic pricing adjustment strategy considering train classification, which could provide a reference for the ticket price management of high-speed railway.
Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development
Authors: Davidson Rebecca K. , Corry Kylie , Orlofsky Amos , Li Ping , Russell Caleb E. , Zhang Amy , Moraes de Lima Perini Mariana , Priddy Carlie N. , Nguyen Andrew V. , Li Jiliang
Published: December 2024

Studies with genetically modified mice have implicated the transcriptional regulator STAT3 as a key modulator of bone development. STAT3-OKO knockout mouse lines were generated in two genetic backgrounds, pure C57BL/6 (STAT3-OKO-BL) and mixed C57BL/6, CD1 (STAT3-OKO-M). Both lines exhibited defective postnatal bone development resulting in reduced body weight and shortened femurs that displayed low bone mineral density as well as cortical widening and thinning in the diaphyseal region. Remarkably, each of these defects displayed sexual dimorphism that was dependent on genetic background: the phenotype was entirely male-specific in STAT3-OKO-M but not in STAT3-OKO-BL, in which defects were similar in both sexes. However, both lines exhibited a male-specific bone defect in mineralization, and also in bone mechanical properties related to bone quality, such as yield stress and ultimate stress. On the other hand, bone mechanical properties such as ultimate force, that may reflect density and macrostructure rather than bone quality, showed male-specific defects only in STAT3-OKO-M. These findings suggest that STAT3 may regulate multiple sex-dependent mechanisms in bone development that control either mineralization or bone accrual, and that the sex-dependence of at least some of these mechanisms is affected by genetic background. Finally, we used CRISPR/Cas9 to generate STAT3-deficient preosteoblastic cells from immortalized wild-type bone marrow stem cells and showed that the defective osteoblastic differentiation of STAT3-ablated cells was associated with reduced gene expression of Wnt3a and Wnt5a, consistent with other studies that identify Wnt signaling pathways as potential effector mechanisms for STAT3-mediated regulation of bone development.
IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia
Authors: Nagel Stefan , Meyer Corinna , Pommerenke Claudia
Published: December 2024

Homeobox genes encode transcription factors which organize differentiation processes in all tissue types including the hematopoietic compartment. Recently, we have reported physiological expression of TALE-class homeobox gene IRX1 in early myelopoiesis restricted to the megakaryocyte-erythroid-progenitor stage and in early B-cell development to the pro-B-cell stage. In contrast, sister homeobox genes IRX2, IRX3 and IRX5 are aberrantly activated in the corresponding malignancies acute myeloid leukemia (AML) and B-cell progenitor acute lymphoid leukemia. Here, we examined the role of IRX-related homeobox gene MKX (also termed IRXL1 or mohawk) in normal and malignant hematopoiesis. Screening of public datasets revealed silent MKX in normal myelopoiesis and B-cell differentiation, and aberrant expression in subsets of AML and multiple myeloma (MM) cell lines and patients. To investigate its dysregulation and oncogenic function we used AML cell line OCI-AML3 as model which strongly expressed MKX at both RNA and protein levels. We found that IRX5, JUNB and NFkB activated MKX in this cell line, while downregulated GATA2 and STAT5 inhibited its expression. MKX downstream analysis was conducted by siRNA-mediated knockdown and RNA-sequencing in OCI-AML3, and by comparative expression profiling analysis of a public dataset from MM patients. Analysis of these data revealed activation of CCL2 which in turn promoted proliferation. Furthermore, MKX upregulated SESN3 and downregulated BCL2L11, which may together underlie decreased etoposide-induced apoptosis. Finally, myeloid differentiation genes CEBPD and GATA2 were respectively up- and downregulated by MKX. Taken together, our study identified MKX as novel aberrantly expressed homeobox gene in AML and MM, highlighting the function of IRX1 in normal myelopoiesis and B-cell development, and of IRX-related genes in corresponding malignancies. Our data merit further investigation of MKX and its deregulated target genes to serve as novel markers and/or potential therapeutic targets in AML patient subsets.
Análisis de la imagen de top macro influencers en Instagram: ¿la publicidad responsable consigue aumentar el engagement?
Authors: Gallego-Gómez Cristina , Carrasco Polaino Rafael , Establés María-José , Llovet Carmen
Published: December 2024

La investigación plantea como objetivos identificar en qué medida los contenidos promocionales que difunden macro influencers mediante Instagram cumplen criterios responsables y analizar cómo el cumplimiento de estos criterios tiene un efecto en el engagement logrado. La metodología aplicada ha sido el análisis de contenido y estadístico de posts de los usuarios más seguidos en España y españoles en 2023. Como conclusión, los influencers cambian su estilo de comunicar cuando generan contenidos promocionales, adoptando un lenguaje más positivo y subjetivo. Por otro lado, cuando se oculta el contenido comercial, el engagement es mayor que cuando se difunde de forma transparente.
El atractivo de los prescriptores digitales en comunicación de belleza y salud: la marca ISDIN y su perfil de Instagram
Authors: Vicente-Fernández Pilar
Published: December 2024

En el escenario digital, las redes sociales se posicionan como importantes aliadas estratégicas para el marketing y la comunicación. Mediante ellas, el prescriptor es un recurso decisivo gracias a su atractivo y credibilidad. Se analiza durante un año (julio 2023-junio 2024) el perfil de Instagram de la marca ISDIN para identificar la relevancia, los mecanismos y la predicación de estos líderes de opinión 2.0. El análisis de contenido (N = 422) determina la preeminencia de la prescripción femenina con propósito comercial en formato vídeo y el rol destacado de embajadores e influencers, así como la tendencia a un discurso emocional en el sector de la belleza y la salud.
Exposición y autopercepción física: el adolescente y la publicidad del influencer sobre cuerpo y dieta en Perú
Authors: Montúfar-Calle Álvaro , Palomino-Moreno Henry
Published: December 2024

La exposición del adolescente a la publicidad del influencer sobre alimentación y cuidado del cuerpo en redes sociales (RS) se ha tornado preocupante pues, además de la dificultad que supone su reconocimiento, puede acarrear repercusiones en la autopercepción física y salud del adolescente. El estudio aplica una encuesta representativa a nivel nacional a 1020 adolescentes de Perú urbano para examinar su exposición y autopercepción física. Los resultados indican alta exposición a esta publicidad, tendencia a la delgadez en la figura ideal de las mujeres, y un alto nivel de insatisfacción y relevancia social del aspecto físico para el adolescente.
Cuerpo, imagen y redes sociales: El impacto y atractivo promocional de los influencers
Authors: Feijoo Beatriz , Vizcaíno-Verdú Arantxa , Núñez-Gómez Patricia
Published: December 2024

La apariencia física ha adquirido una relevancia significativa en la sociedad contemporánea, profundamente influenciada por la hipermediatización y las redes sociales. Si bien, este fenómeno no es novedoso. La búsqueda de una imagen perfecta ha sido históricamente impulsada por la industria del consumo, fomentando la adquisición de productos en sectores como la moda, la cosmética, la estética y la alimentación, entre otros. Lo que en un principio fue capitalizado por la publicidad tradicional como un argumento de venta, ha evolucionado en el ecosistema digital, encontrando nuevas formas de consolidarse a través de plataformas y figuras clave: los influencers. Estos actores han transformado la manera en que los ideales estéticos son construidos y propagados, al tiempo que contribuyen a la creación de nuevas corrientes que desafían los estereotipos comerciales preestablecidos.
OS SENTIDOS DO TRABALHO PARA MOTORISTAS DE ÔNIBUS URBANO
Authors: Barbosa de Oliveira Lucia , Ferreira de Santana Gelson
Published: December 2024

Objetivo: O presente estudo tem por objetivo analisar os sentidos atribuídos ao trabalho por motoristas de ônibus urbano que atuam em grandes cidades.
Design/metodologia/abordagem: Foi conduzida uma pesquisa de natureza qualitativa com a participação de 22 motoristas de uma empresa de ônibus do município do Rio de Janeiro. Os dados foram obtidos a partir de entrevistas semiestruturadas e examinados por meio de análise de conteúdo, com apoio do software Atlas.ti.
Resultados: Os resultados mostraram que a remuneração, considerada relativamente elevada para o nível de escolaridade exigido, e o prazer de dirigir são os principais aspectos que conferem sentido ao trabalho. Além disso, observou-se que o trabalho tem alta centralidade, mas é menos importante do que a família para a maioria dos participantes. Também foram identificadas diferenças entre motoristas maduros e jovens. Apesar de todos afirmarem que gostam da profissão, os maduros demonstram gostar mais do trabalho e se sentem mais reconhecidos, quando comparados aos mais jovens.
Implicações práticas: Como contribuição prática, os resultados podem orientar o desenvolvimento de políticas e práticas de gestão de pessoas que promovam uma experiência de trabalho mais positiva.
Implicações teóricas: A pesquisa contribui para a literatura nacional sobre sentidos do trabalho, ao trazer as perspectivas de motoristas de ônibus, grupo relativamente pouco pesquisado.
Limitações: A pesquisa contou com a participação de motoristas da mesma empresa, aspecto que pode ter limitado uma maior diversidade de perspectivas.
Originalidade/valor: O presente estudo preenche uma lacuna nos estudos nacionais sobre sentidos do trabalho, usualmente focados em profissões de maior status social.
Răzvan Bran: Las oraciones subordinadas y las construcciones sintácticas complejas en español. Consideraciones teóricas y ejercicios prácticos
Authors: Iosef Indra-Flavia-Elena
Published: December 2024

Reseña del libro Las oraciones subordinadas y las construcciones sintácticas complejas en español. Consideraciones teóricas y ejercicios prácticos de Răzvan Bran.
Cervantes y las reminiscencias clásicas del Quijote
Authors: Andino Sánchez Antonio
Published: December 2024

Tomando de botón de muestra los capítulos XXV, XXVI y XXVII de la segunda parte, el artículo hace un estudio filológico del texto cervantino para sacar a la luz los posibles componentes literarios de la tradición clásica, que de la mano de Cervantes cobran nueva vida y vertebran poderosamente la obra más universal de todos los tiempos. Ello permite no solo desentrañar la técnica creadora de la que el alcalaíno hace oficio, sino también penetrar en el secreto de su éxito continuado durante cuatrocientos años hasta nuestros días.
El uso de la conjugación definida en húngaro como lengua extranjera por hispanohablantes
Authors: Durst Péter
Published: December 2024

En este trabajo investigamos el uso de la conjugación definida en húngaro por hablantes de español como lengua materna. Comparamos los resultados que proceden de un análisis de textos orales grabados con resultados de estudios anteriores que utilizaron textos y pruebas escritos e intentamos evaluar dos suposiciones. Nuestra primera suposición, según la cual los errores más frecuentes se realizan con ciertos objetos definidos y que los errores cometidos en un corpus escrito son los mismos que en el habla no se puede confirmar, pero plantea cuestiones relevantes en cuanto a la metodología de recolección de datos. La segunda suposición se basa en la observación que unos errores se realizan no como errores en la producción de la lengua, sino evitando algunas estructuras y nuestros resultados parecen confirmarla en parte, pero debido a algunos subresultados es difícil extraer conclusiones con total seguridad.
A zöldülő Veszprém, avagy hogyan érvényesül a fenntarthatóság a 2073-ban hipotetikusan újrázó Európa Kulturális Fővárosában?
Authors: Michalkó Gábor , Horvát Szilárd , Fehérvölgyi Beáta
Published: December 2024

A fenntartható fejlődés elvének szem előtt tartása a legtöbb kulturális, gasztronómiai vagy sportrendezvény, különösen az úgynevezett megaesemény alfája és ómegája. A fenntarthatóság kulcsfontosságú szerepet játszott Veszprémnek az „Európa Kulturális Fővárosa 2023” cím elnyeréséért benyújtott pályázatában és annak sikeres megvalósításában is. A városba látogatók, az ott élők, ott dolgozók vagy éppen ott tanulók megtapasztalhatták milyen a fenntarthatóság magasztos eszméinek gyakorlatban való érvényesítése. Ahogyan az Európa Kulturális Fővárosa kezdeményezés sem 365 napra szól, úgy a fenntarthatóságra való törekvés sem ér véget újévkor. A tanulmány abból a feltételezésből indul ki, hogy Veszprém 2073-ban újra elnyeri az Európa Kulturális Fővárosa címet és a mai Z-generáció képviselői, nevezetesen a Pannon Egyetem másodéves turizmus-vendéglátás szakos hallgatói fél évszázad múlva elutaznak diákéveik színhelyére és élményeikről az akkori közösségi oldalukon számolnak be. A 63 fiktív úti beszámoló lehetőséget biztosított a fenntarthatóság tárgykörébe tartozó élményelemek vizsgálatára. A félig irányított esszék manuális kódolású tartalomelemzésének segítségével arra a kérdésre kerestük a választ, hogy az elméletben elsajátított és az empirikusan megélt fenntarthatóság hogyan él tovább a hallgatók utazáshoz kötődő fantáziájában. A vizsgálat megállapította, hogy (1) a fenntarthatóság eszméje és gyakorlata egyaránt markáns szerepet játszik az 50 év múlva megvalósuló utazásból fakadó élményekben, (2) a fejlesztések napjaink innovációinak talaján állnak, (3) Veszprém a jelenleginél is zöldebb és élhetőbb vármegyeszékhellyé válik.
A beszerzés etikai problémái és kihívásai a válság nyomán
Authors: Vörösmarty Gyöngyi , Tátrai Tünde
Published: December 2024

A szerzők kutatásának középpontjában annak vizsgálata állt, hogy az üzleti életben a szervezetek beszerzéseinél az etikusság, az egyes etikai problémák hogyan változtak meg az elmúlt évek világgazdasági és ellátási problémáinak hatására. Egy korábbi felmérést ismételtek meg, majd összevetették az eredményeket. A válaszokat a kérdőív nyílt kérdéseinek vizsgálata árnyalja. Az eredmények szerint az utóbbi évek ellátási problémái, a beszerzéssel szemben jelentkező új kihívások – mint például a digitalizáció – új problémák elé állították a szakmát. A szakirodalom a tulajdonos és a beszerző, illetve a beszerző és a beszállító érdekkonfliktusa köré csoportosítva tárgyalja a problémákat, az eredmények azonban azt mutatják, hogy az etikai konfliktus az érintettek szélesebb körét érinti, s a hagyományos etikai problémák is új értelmezéseket kapnak.
การประเมินโครงการการพัฒนาคุณลักษณะอันพึงประสงค์ของนักเรียน โดยใช้หลักสูตรรายวิชาสตรีวิทยา ๒ ในพระราชูปถัมภ์ฯ ศึกษา
Authors:   โรงเรียนสตรีวิทยา ๒ ในพระราชูปถัมภ์ฯ จังหวัดกรุงเทพมหานคร, กานต์ภูวนันต์ กัญญาพัชญ์
Published: December 2024

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อประเมินโครงการการพัฒนาคุณลักษณะอันพึงประสงค์ของนักเรียน โดยใช้หลักสูตรรายวิชาสตรีวิทยา ๒ ในพระราชูปถัมภ์ฯ ศึกษา โดยใช้รูปแบบการประเมินแบบ CIPPIEST Model ประเมินทั้งระบบของโครงการ กลุ่มตัวอย่างที่ใช้ในการวิจัย จำนวน 1,868 คน ได้แก่ คณะกรรมการสถานศึกษาขั้นพื้นฐาน จำนวน 14 คน ผู้บริหารสถานศึกษา จำนวน 3 คน ครูฝ่ายแผนงานและครูผู้รับผิดชอบโครงการ จำนวน 8 คน ครูผู้สอน จำนวน 20 คน ครูหัวหน้ากลุ่มสาระการเรียนรู้และกิจกรรมพัฒนาผู้เรียน จำนวน 18 คน ครูหัวหน้าคณะ จำนวน 10 คน นักเรียน จำนวน 1,480 คน และผู้ปกครอง จำนวน 315 คน โดยใช้วิธีการเลือกแบบเจาะจงและวิธีการสุ่มแบบแบ่งชั้น เครื่องมือที่ใช้ในการวิจัยเป็นแบบสอบถามประมาณค่า 5 ระดับ สถิติที่ใช้ในการวิเคราะห์ข้อมูล ได้แก่ ร้อยละ ค่าเฉลี่ย และค่าเบี่ยงเบนมาตรฐาน
ผลการวิจัยพบว่า 1) ผลการประเมินด้านบริบท โดยภาพรวมมีความเหมาะสมอยู่ในระดับมาก 2) ผลการประเมินด้านปัจจัยนำเข้า โดยภาพรวมมีความเหมาะสมอยู่ในระดับมาก 3) ผลการประเมินด้านกระบวนการ โดยภาพรวมมีความเหมาะสมอยู่ในระดับมาก 4) ผลการประเมินด้านผลผลิต โดยภาพรวมมีความเหมาะสมอยู่ในระดับมากที่สุด ซึ่งประกอบด้วย 4.1) ผลการประเมินด้านผลกระทบ โดยภาพรวมมีความเหมาะสมอยู่ในระดับมากที่สุด 4.2) ผลการประเมินด้านประสิทธิผล โดยภาพรวมมีความเหมาะสมอยู่ในระดับมากที่สุด 4.3) ผลการประเมินด้านความยั่งยืน โดยภาพรวมมีความเหมาะสมอยู่ในระดับมากที่สุด และ 4.4) ผลการประเมินด้านการถ่ายทอดส่งต่อ โดยภาพรวมมีความเหมาะสมอยู่ในระดับมากที่สุด
A reflective overview: European vocational education and training reform: The Copenhagen process 2002 to 2024
Authors: Bainbridge Steven
Published: December 2024

The European Union’s (EU) Copenhagen Process on cooperation in vocational education and training (VET), initiated in 2002, is a voluntary method that coordinates VET reform in Europe. In terms of this process, EU Member States, the European Commission and the social partners agree, at ministerial level, on common VET-related objectives, priorities and statistical targets to be met over a five- to ten-year period. Progress is monitored and political momentum maintained through regular reporting, exchanges of experience and periodic revisions of reform objectives, priorities and statistical targets. This article outlines the origins of the Copenhagen Process and discusses its evolution and influence on European VET policy since 2002. The writer argues that the process has proved to be an effective working method. It has strengthened European cooperation in VET, provided the basis for common European instruments and principles, influenced national reforms and raised the profile of VET in other policy areas. The writer also argues that, while the Copenhagen Process has operated at a multinational, trans-European level, its principles of partnership, resources and momentum can be used to create effective partnerships and networks at national, sectoral and local levels in order to bring about VET reform.
Interannual spatio-temporal evolution of the supraglacial lakes on the Belvedere Glacier between 2000 and 2023
Authors: Brodský Lukáš , Rusnák Samo , Schmidt Susanne , Vilímek Vít , Azzoni Roberto Sergio , Nüsser Marcus , Tronti Gianluca , Kropáček Jan , Pandey Aayushi
Published: December 2024

Understanding of the formation and evolution of supraglacial lakes in high mountain regions is crucial for accurately assessing their impact on glacier behaviour, hydrology, and potential hazards such as outburst floods. This article examines the annual spatio-temporal evolution of supraglacial lakes on the Belvedere Glacier between 2000 and 2023. Very high-resolution aerial photography and high-resolution satellite imagery were used to identify supraglacial lakes as small as 37 m2 and narrow bands of ice-marginal lakes. The mapping revealed that the well-known Lake Effimero is stable in its position but unstable in size, with variations from 428 m2 to 99.7 × 103 m2. These changes are potentially due to snowmelt or glacier dynamics. In 2002, the area of Effimero was at its largest extent observed during the study period. The first appearance of the Lake Effimero was revelated by the Landsat imagery on 27 May 2001, which differed from the findings of other studies. New lakes were observed to form in a manner independent of Effimero formation, exhibiting a consistent annual occurrence with nearly linear area growth up to 9.7 × 103 m2 in 2023. The formation of the lakes is shown to be influenced by their morphological characteristics.
Snake Island in the Romanian and Ukrainian narrative in the International Court of Justice
Authors: Kastory Agnieszka Małgorzata
Published: December 2024

In 1948 Romania ceded Snake Island to the Soviet Union, which established a 12-mile maritime zone around the island. After the collapse of the USSR, the island was incorporated into Ukraine. Romania recognized that the island belonged to Ukraine, but a long-running dispute began between Ukraine and Romania over the delimitation of the shelf and the exclusive economic zone. Snake Island became part of this dispute because Ukraine considered it a reference point for the delimitation of the maritime waters. Romania strongly disagreed and referred the dispute to the International Court of Justice in The Hague. Both countries presented their arguments not only from the legal, but also historical point of view. They drew completely different conclusions from the same historical sources while presenting their interpretations of the past regarding Snake Island. The dispute ended when the ICJ announced its verdict on February 3, 2009. Both countries accepted it.
Ewolucja osadnictwa na prawie wołoskim w Karpatach polskich
Authors: Kłapyta Piotr
Published: December 2024

Celem artykułu jest przedstawienie czasowej i przestrzennej ewolucji osadnictwa na prawie wołoskim w polskiej części Karpat. Przygotowano serię map tematycznych, które przedstawiają rozmieszczenie osad w okresie ponad 300 lat, od drugiej połowy XIV wieku do drugiej połowy XVII wieku. Na obszarze fizycznogeograficznym polskich Karpat łącznie udokumentowano 479 miejscowości opartych na prawie wołoskim lub z poświadczoną obecnością Wołochów. Stanowiły one 28% wszystkich miejscowości w tym regionie. Należy podkreślić, że 70% (339) tych osad zniknęło w wyniku przymusowych przesiedleń ludności z lat 1946–1950. W historii wołoskiego osadnictwa w polskich Karpatach wyróżnia się dwie fazy. Pierwsza (od drugiej połowy XIV wieku do końca XV wieku) była związana głównie z militarną, strażniczą funkcją osad - powstało wówczas 87 nowych lokalizacji. Druga faza (od XVI do końca XVII wieku) była raczej uwarunkowana przez czynniki gospodarcze, stymulowane zmianami klimatycznymi podczas tzw. Małej Epoki Lodowej. W okresie tym doszło do zwiększenia dynamiki osadnictwa wołoskiego, co zaowocowało stworzeniem 392 osad w strefie górskiej, mającej złe warunki do prowadzenia gospodarki rolnej (powyżej 500 m n.p.m.). Osadnictwo na prawie wołoskim straciło swój pierwotnie etniczny charakter, stając się narzędziem umożliwiającym efektywną kolonizację Karpat w oparciu o gospodarkę pasterską lub pastersko-rolniczą.
Politics of the French empire in the east Adriatic coast (1809–1814)
Authors: Prekic Adnan
Published: December 2024

The article processes the period of the French Empire’s rule on the east Adriatic coast between 1809 and 1814. Based on the relevant literature and historical sources, the article points to events that followed Campo Formio's peace in 1797 until the destruction of French rule in 1814. Special focus is placed on the activities of the new rulers, based on the ideas of the French revolutions, which sought to transform the area of east Adriatic and integrate it into the state system of the French empire, with the goal of creating a united political, administrative, militaristic, economic and cultural-educational area. In that context, in the article, the main question being examined is the formation of the Illyrian provinces, which were intended to be a separate province of the French empire, which was supposed to unite different national and religious communities that spoke the same language. With a comprehensive analysis of political and social changes, an attempt is made to point to a pioneer attempt to transform a patriarchal and traditional community, through the implementation of modern models of public administration, healthcare, and education.
Tracja Zachodnia jako region pograniczny w świetle przemian geopolitycznych i ludnościowych po I wojnie światowej (1919–1928)
Authors: Paszkiewicz Jędrzej
Published: December 2024

Celem artykułu jest ukazanie pograniczności regionu o nazwie Tracja zachodnia przez pryzmat zmian demograficznych i społeczno-politycznych, jakie nastąpiły tam po I wojnie światowej i przejęciu władzy przez Grecję. Do początku XX w. obszar ten, stanowiący część Turcji osmańskiej i zamieszkany przez społeczności o zróżnicowanej charakterystyce kulturowej, stanowił część historyczno-geograficznego regionu o nazwie Tracja. Za odrębną jednostkę terytorialną zaczęto go uznawać od czasu wojen bałkańskich (buł. Tracja egejska, tur. i gr. Tracja zachodnia). W 1920 r. został on ostatecznie przyłączony do Grecji. Na podstawie dokumentacji pochodzącej od przedstawicieli wojsk Ententy, Ligi Narodów i władz greckich, przedstawione zostaną procesy, które złożyły się na ugruntowanie dychotomicznego krajobrazu kulturowego w regionie, funkcjonującego do czasów dzisiejszych. Z jednej strony podporządkowano je paradygmatowi unitarnego państwa narodowego, z drugiej uwzględniono autonomię religijną dla ponad stu tysięcy muzułmanów. W praktyce rozwiązanie to przyczyniło się jednak do izolowania (gettoizacji) muzułmańskiej wspólnoty mniejszościowej, spowolniło integrację muzułmanów ze społeczeństwem greckim i wzmocniło kontrolę administracji centralnej nad sprawami regionu.
Theology of God’s Energies in Selected Texts by Georges Florovsky
Authors: Kiejkowski Paweł
Published: December 2024

Georges Vasilievich Florovsky (1893–1979) was a prominent 20th century Orthodox priest, theologian and writer involved in the ecumenical movement. In his writing he addressed almost every aspect of the Christian life. G. Florovsky is part of the great emigration of Russian intellectuals, together with M. Berdyaev, S. Bulgakov, M. Lossky, A. Schumann and J. Meyndorf. In his speech to Orthodox theologians gathered in Athens in 1936, he emphasized that the doctrine of energies is one of the truths that needs to be rediscovered by Orthodox theology. His teachings on this subject can be found primarily in three studies: Твар и тварность, Понятие творения у святителя Афанася Великого, Святитель Григoрий Палама и трaдиция Отцов. The starting point for Florovsky’s thought is the thesis that the created world does not have to exist. Creation finds its foundation in God’s will, not in God’s nature or essence. The distinction between nature/essence and will becomes the basis for G. Florovsky to justify the distinction between essence and energies in God. The distinction between essence and energies is effectively the distinction between necessity and free will. This, in turn, becomes the basis for the proper ontological distinction between God and creation. The energies represent God’s will and grace that make creation and new creation (deification) possible. The energies are understood as the action of the entire undivided Holy Trinity.
Rzymskie celebracje liturgiczne Jubileuszu 1500 roku
Authors: Żak Łukasz
Published: December 2024

Celem artykułu jest analiza najważniejszych celebracji liturgicznych, które odbyły się w Rzymie podczas roku jubileuszowego 1500 i zostały opisane przez papieskiego ceremoniarza Johannesa Burcharda. Autor ukazuje różne wymiary papieskich ceremonii (polityczny, religijny, wizualny); w szczególny sposób zwraca uwagę na ryt otwarcia drzwi świętych, msze odprawiane przez papieża w bazylice św. Piotra, obchody Bożego Ciała i procesje z ikonami maryjnymi.
L'ibridismo nell'opera primoleviana
Authors: Tichoniuk -Wawrowicz Ewa
Published: December 2024

The paper is dedicated to the writer's fascination of complexity of the universe and hybridism. He used to call himself a centaur, because of his double disposition: novelist/poet and chemist. Levi, stretched between being Italian and Jew, writer and chemist, commentator and translator, between the «daily» and «nightly» writing, was able to transcend the common division between letters and science. He was interested in contamination, mixture, mutation, and discussed hybridity in many essays and literary scherzos to show convolutions of human condition and prolific richness of life. Levi's unusual powers of observation combine with an abundance of themes and literary forms, which proves that his works are marked by hybridism at morphological level as well.
Identité et altčrilč dans le roman québécois
Authors: Voldrichová Beránková Eva
Published: December 2024

As a « relational concept », alterity can only be defined in opposition to what sociologists call a « referential group », an entity which dictates political, religious or cultural norms in a concrete society. Our article will first explain the difference between simple « diversity » and real « alterity », which is perceived as a potential source of threat by the majority society. Using concrete figures from 19th and 20th century Quebec novels, we will illustrate various types of alterity and the general evolution of Canadian mentality in relation to various minorities.
Un aspetto particolare del plurilinguismo della societŕ italiana: il rapporto lingua vs. dialetti nell'insegnamento scolastico in Italia
Authors: Beszterda Ingeborga
Published: December 2024

This article presents the issue of linguistic policy and the attitude of educational authorities towards dialects from the point of view of the multi-lingual and multiculture Italian society. Due to specific historical conditions the linguistic situation in Italy is characterized by a high degree of heterogeneity -numerous dialects exist alongside the national language. After the period of the political unity of Italy in 1861 the educational authorities have had to tackle two problems: the necessity of having to choose a linguistic norm and also mutual relations between the language and the dialects. Those issues were and still are highly controversial and are subject to heated polemics as the answer to the question of whether to accept dialects or eliminate them from school education has never been found.
Sobre los orígenes y las confusiones terminológicoconceptuales de los términos de "aspecto"y de "Aktionsart"
Authors: Pawlak Aneta
Published: December 2024

The paper presents, on the one hand, various terms that assign the categories of aspect and Aktionsart and, on the other hand, emphasizes that the concepts regarding them are not homogeneous. The confusions are supposed to have originated in the past. Therefore, we'll sketch briefly the history of aspect and Aktionsart in order to show that the term and the concept of aspect should be related exclusively to the Slavonic languages.
THE IMPACT OF TATTOOS ON CONSUMER BEHAVIOR AND PURCHASING DECISIONS: AN EMPIRICAL RESEARCH
Authors: Şehirli Mustafa
Published: December 2024

The purpose of this study is to understand the effects of tattoos, which have become increasingly widespread and undergone changes in meaning, on potential consumers through various variables (whether the researcher has a tattoo, the region where they live, whether the participant has a tattoo) and to provide brand managers with enlightening information, particularly when making decisions related to employees. The researchers conducted live applications with one tattooed and one non-tattooed researcher. They conducted interviews with 260 participants in two different locations. They tested the cognitive, emotional, and behavioural effects of tattoos on participants through both a marketing research approach and a product (book) shopping scenario. The findings indicate that tattoos have become socially internalized and widespread. Additionally, while the researchers' possession of a tattoo slightly affects participants' thoughts, it may lead to an average of 43% lower offers from buyers. Tattoo ownership triggers qualitative concepts such as transaction quality rather than quantitative ones like price. Tattooed participants promised to donate 49% more to a charity. On the other hand, the nature of the product in purchases can alter the effects of tattoos. Marketing strategists should consider these differences, particularly when determining employees who will communicate with customers.
Development of microsatellite markers for colony delineation of the invasive Asian subterranean termite (Blattodea: Rhinotermitidae) in South Florida and Taiwan
Authors: Tsai Cheng-Lung , Li Hou-Feng , Ching Yung-Hao , Lin Ming-Der , Chen Guan-Yu , Mullins Aaron , Scheffrahn Rudolf H. , Chouvenc Thomas , Su Nan-Yao
Published: December 2024

The Asian subterranean termite, Coptotermes gestroi (Wasmann) (Blattodea: Rhinotermitidae), is a major pest of wooden structures. Native to Southeast Asia, it has successfully invaded various regions worldwide. Developing a molecular technique for colony delineation is critical to evaluate the efficacy of subterranean termite baiting systems against C. gestroi. This study has assessed the robustness of 19 newly developed microsatellite loci for colony delineation of the invasive C. gestroi in both South Florida and Taiwan. Our results suggest that at least nine microsatellite markers, each with two alleles per locus, can accurately distinguish all C. gestroi colonies with little genetic variation in South Florida. Conversely, only five microsatellite loci are needed to delineate C. gestroi colonies in Taiwan. Additionally, differences in colony breeding systems may affect genetic differentiation among C. gestroi colonies. Our study provides a practical genetic method to accurately identify colony affiliation of foragers, which will help in the field evaluation of baiting systems in areas invaded by C. gestroi.
Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic cancer target Aurora 2 Kinase
Authors: Prabhakaran Pratibha , Palanisamy Chella Perumal , Shanmugam Abirami , Damodharan Prabhu , Swaminathan Harshini , Devaraj Dhivya , Ahalliya Rathi Muthaiyan , Velliyur Kanniappan Gopalakrishnan
Published: December 2024

Objectives

Natural flora historically has played a substantial part in drug development since they serve as active ingredients in medications and templates for the synthesis of novel pharmaceuticals. Emilia sonchifolia is a conventionally utilised therapeutic flora in Indian pharmacopoeia. Therefore, the current study is intended to separate, structurally describe and analyse the anti-pancreatic cancer potential of isolated natural bio-constituents from E. sonchifolia (L.) DC.

Methods

n-Hexane extract using chromatographic techniques and structurally characterize them using spectroscopic techniques. Further, in silico molecular docking method was employed to investigate the bioactivity of the isolated compound against Aurora 2 Kinase (pancreatic cancer target protein).

Results

A mixture of stigmasterol with straight-chain monounsaturated alcohol (C49H86O) was isolated and identified from the aerial parts of E. sonchifolia using chromatographic techniques. The docking results showed that the isolated natural compound of stigmasterol with straight-chain monounsaturated alcohol has good docking results compared with Food and Drug Administration-permitted medicine.

Conclusions

Based on the outcomes, it can be concluded that the stigmasterol with straight-chain monounsaturated alcohol may act as a novel inhibitor for Aurora 2 Kinase. In the future, it may lead to the development of drugs targeting Aurora 2 Kinase for the effective treatment of pancreatic cancer.
On the multiplicative sum Zagreb index of molecular graphs
Authors: Sun Xiaoling , Du Jianwei , Mei Yinzhen
Published: December 2024

Multiplicative sum Zagreb index is a modified version of the famous Zagreb indices. For a graph

G

G

, the multiplicative sum Zagreb index is defined as

Π

1

*

(

G

)

=

∏

u
v
∈
E

(

G

)

(

d

G

(

u

)

+

d

G

(

v

)

)

{\Pi }_{1}^{* }\left(G)={\prod }_{uv\in E\left(G)}\left({d}_{G}\left(u)+{d}_{G}\left(v))

, where

E

(

G

)

E\left(G)

is the edge set of

G

G

and

d

G

(

u

)

{d}_{G}\left(u)

stands for the degree of vertex

u

u

in

G

G

. In this article, we determine the extremal multiplicative sum Zagreb indices among all

n

n

-vertex molecular trees, molecular unicyclic graphs, molecular bicyclic graphs and molecular tricyclic graphs.
Energy efficiency in materials testing by reactive power – part 1: power recirculating method in wear testing
Authors: Findeisen Dietmar , Schröpfer Dirk
Published: December 2024

Reactive power is related to the type of power that does not consume energy but stores it. In the design of test machines, the utilization of this physical phenomenon would be very beneficial. Reactive power allows for the combination of power amplification with energy savings, making it an ideal principle for conducting long-term tests that involve high loads and prolonged energy consumption. This concept is illustrated in this work focusing test machines used in rotary testing procedures. Drive element pairs, which serve as component test objects, are primarily exposed to wear stress. These stressed element pairs are consequently integral parts of a tribological system. The underlying principles of power amplification and power feedback are explained from the perspectives of drive technology, systematic design, methodical design, and mechatronics.