bluuebunny/crossref_metadata_2025 huggingface dataset:
Future Climate Projections for Tacna, Peru: Assessing Changes in Temperature and Precipitation
Authors: De la Cruz Gustavo , Huerta Adrian , Franco-León Pablo , Pino-Vargas Edwin , Ramos-Fernández Lía , Lavado-Casimiro Waldo
Published: January 2025

The Tacna region, situated in southwestern Peru, is distinguished by its desert and Andean zones, resulting in significant climatic variability. However, changes in future precipitation and temperature patterns could significantly impact sectors such as agriculture, energy, and water resources. In this context, this research analyzes climate scenarios of precipitation, maximum temperature (Tmax), and minimum temperature (Tmin) in Tacna. For this purpose, Tacna was divided into four homogeneous regions (Coast, Low Highlands, High Andes, and Andean Plateau) to assess future changes using CMIP6 climate models for the SSP1-2.6, SSP2-4.5, and SSP5-8.5 scenarios. A bias correction of these models was applied using the Quantile Delta Mapping method to improve accuracy. The validation results showed better performance for minimum temperature compared to maximum temperature and precipitation. Regarding the scenario results, by the end of the century, under the SSP5-8.5 scenario, Tmax could increase by up to +7 °C while Tmin could rise by up to +5 °C, particularly in the Andean Plateau. Precipitation is projected to decrease by up to 20% annually in higher elevations, albeit with considerable uncertainty; however, no significant changes are expected in seasonal patterns. This study underscores the importance of robust climate projections in formulating adaptation strategies for water resource management and infrastructure planning. The findings provide essential insights for decision-makers to address the challenges posed by climate change in vulnerable regions of southern Peru.
The Efficacy of an Active Medicinal Alkaloid, Berbamine, in Reducing Overactive Bladder Symptoms in a Retinyl Acetate-Induced Model
Authors: Wróbel Jan , Zapała Łukasz , Niemczyk Grzegorz , Poleszak Ewa , Dobrowolski Piotr , Kluz Tomasz , Bogaczyk Anna , Jasielski Patryk , Wdowiak Artur , Bojar Iwona , Misiek Marcin , Wróbel Andrzej
Published: January 2025

We aimed to determine whether berbamine (BBM) would have an effect on retinyl acetate (RA)-induced cystometric and biochemical parameters, characteristic of bladder overactivity. BBM exhibits anti-inflammatory, anti-oxidant, and muscle-relaxant effects which could counteract pathophysiological mechanisms observed in overactive bladder (OAB) syndrome. The cohort of 60 rats was divided into 4 groups: I—control, II—RA group, III—BBM, and IV—group with the combination of RA + BBM. The cystometry, BBF, cardiovascular parameters and diuresis, the analysis of the cFos, and biochemical biomarker levels were analyzed 48 h after completion of BRB administration. The examined substance turned out to reverse the cystometric changes and c-Fos expression changes induced by RA when compared to the control group. There were no significant changes observed in the analyzed groups of animals MAP, HR, BBF, or UP. Importantly, BBM also turned out to reduce the level of OAB biomarkers present in urine (NGF, BDNF), urothelium (TRPV1, SNAP29, ATP, CGRP, or OCT-3), bladder detrusor muscle (VAChT, Rho kinase) as well as to reduce the exponents of oxidative stress (3-nitrotyrosine, malondialdehyde). The multifactorial explanation of the successful alleviation of the RA-induced detrusor overactivity makes the concept of incorporation of BBM in the OAB treatment promising for the future research.
Transcriptional Responses of In Vitro Blood–Brain Barrier Models to Shear Stress
Authors: Foreman Koji L. , Gastfriend Benjamin D. , Katt Moriah E. , Palecek Sean P. , Shusta Eric V.
Published: January 2025

Endothelial cells throughout the body sense blood flow, eliciting transcriptional and phenotypic responses. The brain endothelium, known as the blood–brain barrier (BBB), possesses unique barrier and transport properties, which are in part regulated by blood flow. We utilized RNA sequencing to analyze the transcriptome of primary cultured rat brain microvascular endothelial cells (BMECs), as well as three human induced pluripotent stem cell-derived models. We compared the transcriptional responses of these cells to either low (0.5 dyne/cm2) or high (12 dyne/cm2) shear stresses, and subsequent analyses identified genes and pathways that were influenced by shear including key BBB-associated genes (SLC2A1, LSR, PLVAP) and canonical endothelial shear-stress-response transcription factors (KLF2, KLF4). In addition, our analysis suggests that shear alone is insufficient to rescue the de-differentiation caused by in vitro primary BMEC culture. Overall, these datasets and analyses provide new insights into the influence of shear on BBB models that will aid in model selection and guide further model development.
Enzyme Biosensor Based on 3D-Printed Flow-Through Reactor Modified with Thiacalixarene-Functionalized Oligo (Lactic Acids)
Authors: Stoikov Dmitry , Kappo Dominika , Ivanov Alexey , Gorbachuk Vladimir , Mostovaya Olga , Padnya Pavel , Stoikov Ivan , Evtugyn Gennady
Published: January 2025

Electrochemical enzyme biosensors are extensively utilized in clinical analysis and environmental monitoring, yet achieving effective enzyme immobilization while maintaining high activity remains a challenge. In this work, we developed a flow-through enzyme biosensor system using a 3D-printed flow-through electrochemical cell fabricated from commercially available poly (lactic acid). After modification with thiacalixarene-functionalized oligo (lactic acids) (OLAs), the material enabled efficient immobilization of uricase on the inner surface of a replaceable reactor of the cell. Swelling and hydrolytic stability of OLAs in cone, partial cone, and 1,3-alternate conformations were studied, with 1,3-alernate conformation demonstrating superior stability and enzyme immobilization performance. The use of OLAs enhanced immobilization efficiency by over 30% and protected the reactor from swelling, hydrolytic degradation, and enzyme loss. The biosensor was validated for amperometric uric acid determination, with a screen-printed carbon electrode modified with carbon black and Prussian Blue. This modification reduced the cathodic potential for uric acid detection to –0.05 V. The biosensor exhibited a linear detection range of 10 nM to 30 μM with a detection limit of 7 nM, and it performed effectively in artificial urine and synthetic blood plasma. The novel cell design, featuring easy assembly and low-cost replaceable parts, makes this biosensor a promising candidate for routine clinical analysis and other practical applications.
A Computational Analysis of the Effect of Hard Choices on the Individuation of Values
Authors: Grzywacz Norberto M.
Published: January 2025

Background/Objectives: Experimental studies show that when an individual makes choices, they affect future decisions. Future choices tend to be consistent with past ones. This tendency matters in the context of ambivalent situations because they may not lead to clear choices, often leading people to make “arbitrary” decisions. Thus, because of choice consistency with the past, people’s decision-making values diverge. Thus, hard choices may contribute to the individuation of values. Methods: Here, we develop a Bayesian framework for the effects of cognitive choice consistency on decision-making. This framework thus extends earlier cognitive-science Bayesian theories, which focus on other tasks, such as inference. The minimization of total surprisals considering the history of stimuli and chosen actions implements choice consistency in our framework. We then use a computational model based on this framework to study the effect of hard choices on decision-making values. Results: The results for action selection based on sensory stimuli show that hard choices can cause the spontaneous symmetry breaking of the decision-making space. This spontaneous symmetry breaking is different across individuals, leading to individuation. If in addition, rewards are given to certain choices, then the direction of the symmetry breaking can be guided by these incentives. Finally, we explore the effects of the parametric complexity of the model, the number of choices, and the length of choice memory. Conclusions: Considering the brain’s mechanism of choice consistency and the number of hard choices made in life, we hypothesize that they contribute to individuality. We assess this hypothesis by placing our study in the context of the cognition-of-individuality literature and proposing experimental tests of our computational results.
Finite Element Method Analysis of Seismic Response of Confined Masonry Walls with Openings Built Using Polyurethane Glue
Authors: Krtinić Nemanja , Marinković Marko , Gams Matija
Published: January 2025

The seismic response of confined masonry (CM) walls, built from innovative hollow clay blocks featuring large thermal insulation cavities and bonded with polyurethane glue instead of thin-layer mortar, was investigated. A 3D micro-model was subsequently developed in Abaqus and validated against results from cyclic shear tests on full-scale CM wall specimens. Once validated, the model was utilized in an extensive parametric study to investigate the effects of openings on the walls. This parametric study considered the size of the opening, its position, the aspect ratio of the walls, and different sizes of tie-columns. The results showed that the size and placement of openings substantially and negatively affected seismic response, and that the detrimental effects can be alleviated by placing strong tie-columns next to the openings.
Application of BIM-Driven BEM Methodologies for Enhancing Energy Efficiency in Retrofitting Projects in Morocco: A Socio-Technical Perspective
Authors: Afa Rim , Sobhy Issam , Brakez Abderrahim
Published: January 2025

Conducting accurate and quick energy analyses for retrofitting purposes became crucial for Architecture, Engineering, Construction, and Operations (AECO) markets worldwide. This paper investigates the possibility of determining and implementing an architect-friendly BIM-based energy analysis for Morocco’s Energy Efficiency Retrofitting (EER). For this matter, a socio-technical approach is adopted. The technical part of the study assesses two Building Information Modeling (BIM) tools (ArchiCAD v26 and Revit v23) regarding their Building Energy Modeling (BEM) capabilities for EER. Their evaluation uses a confirmed case of EER located in Marrakech as a baseline to compare the two tools. The social part investigates the AECO market of Marrakech, where the baseline is located, to anticipate the strengths and limits that might influence the implementation of the BIM-based BEM for an EER workflow in architecture studios. The technical part underlines the significant potential of the chosen BIM tools: ArchiCAD is more flexible, customizable, and accurate regarding energy analysis results, while Revit allows for the strong integration of regulations within its process. The social investigation showcases the studied market’s potential for adopting BIM and BEM for EER but highlights the issue of persisting 2D Computer-Aided Design (CAD) workflows. The same social investigation also suggests that combining BIM tools (ArchiCAD and Revit) in the same workflow might benefit the studied market more because of AECO professionals’ diverse needs. These findings constitute a first base for the national implementation of a BIM-based BEM for EER. They also hold the potential to be used in emerging economies with similar AECO markets.
Eribulin-Induced Peripheral Neuropathy in Locally Advanced or Metastatic Breast Cancer: Final Analysis of the Prospective Cohort IRENE Study
Authors: Schmidt Marcus , Hesse Tobias , Hoffmann Oliver , Heinrich Bernhard J. , Park-Simon Tjoung-Won , Grischke Eva-Maria , Weide Rudolf , Müller Huesmann Harald , Lüdtke-Heckenkamp Kerstin , Fischer Dorothea , Zemlin Cosima , Kögel Matthias , Jia Yan , Schmitz Helga , Engelbrecht Christian , Jackisch Christian
Published: January 2025

Eribulin is a preferred treatment for patients with advanced breast cancer (BC) following anthracyclines and taxanes. The final analysis of the IRENE study assessed the incidence and resolution of eribulin-induced peripheral neuropathy (EIPN), along with safety and quality of life (QoL), in patients with advanced/metastatic BC. IRENE was an observational, single-arm, prospective, multicenter cohort study. Patients aged ≥18 years with locally advanced/metastatic BC that progressed after 1–3 prior chemotherapeutic regimens received eribulin and were monitored for new-onset or worsening EIPN. Secondary endpoints included time to disease progression, safety, and health-related QoL. In total, 108 (32.2%) out of 335 patients experienced EIPN; 18 (5.4%) experienced grade ≥3 EIPN. Median time to EIPN resolution (EIPN ended or returned to baseline) was 78.7 weeks (95% CI 77.1—not estimable). Median time to disease progression was 4.5 months (95% CI 3.9–5.5). Treatment-emergent adverse events (TEAEs) occurred in 322 (96.1%) patients; serious TEAEs occurred in 185 (55.2%) patients. Incidence and resolution rates of EIPN were comparable with existing evidence from previous trials. TEAEs were consistent with the established eribulin safety profile, with no new safety signals. Eribulin treatment did not appear to affect QoL, as measured by EQ-5D-3L and EQ-VAS, or patient-reported neuropathy symptoms, as measured by the PNQ.
The Challenge of Managing Neuropathic Pain in Children and Adolescents with Cancer
Authors: Coluzzi Flaminia , Di Stefano Giulia , Scerpa Maria Sole , Rocco Monica , Di Nardo Giovanni , Innocenti Alice , Vittori Alessandro , Ferretti Alessandro , Truini Andrea
Published: January 2025

Neuropathic pain (NP) is a common complication associated with some types of childhood cancer, mainly due to nerve compression, chronic post-surgical pain, chemotherapy, and radiotherapy. NP is usually less responsive to traditional analgesics, and there is generally a lack of evidence on its management in cancer patients, leading to recommendations often based on clinical trials conducted on other forms of non-malignant NP. In pediatric oncology, managing NP is still very challenging for physicians. Different factors contribute to increasing the risk of undertreatment: (a) children may be unable to describe the quality of pain; therefore, the risk for NP to be underestimated or remain unrecognized; (b) specific tools to diagnose NP have not been validated in children; (c) there is a lack of randomized clinical trials involving children, with most evidence being based on case series and case reports; (d) most drugs used for adult patients are not approved for childhood cancers, and drug regulation varies among different countries; (e) recommendations for pediatric pain treatment are still not available. In this paper, a multidisciplinary team will review the current literature regarding children with cancer-related NP to define the best possible diagnostic strategies (e.g., clinical and instrumental tests) and propose a therapeutic care pathway, including both non-pharmacological and pharmacological approaches, which could help pediatricians, oncologists, neurologists, and pain therapists in designing the most effective multidisciplinary approach.
Single-Cell RNA Sequencing on Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Identified Multi-Ciliary Cells in Breast Cancer
Authors: González-Martínez Silvia , Palacios José , Carretero-Barrio Irene , Lanza Val F. , García-Cosío Piqueras Mónica , Caniego-Casas Tamara , Hardisson David , Esteban-Rodríguez Isabel , Cortés Javier , Pérez-Mies Belén
Published: January 2025

The purpose of this study was to evaluate the suitability of formalin-fixed and paraffin-embedded (FFPE) samples and fixed fresh (FF) samples for single-cell RNA sequencing (scRNAseq). To this end, we compared single-cell profiles from FFPE and matched FF tissue samples of one invasive carcinoma of no special type carcinoma (invasive ductal carcinoma–IDC) and one invasive lobular carcinoma (ILC) to assess consistency in cell type distribution and molecular profiles. The results were validated using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and electron microscopy. Additionally, immune cell proportions identified by IHC were quantified using QuPath and compared to the scRNAseq results. FFPE- and FF-derived libraries demonstrated high-quality sequencing metrics, and cellular heterogeneity was similar. No exclusive cell populations were identified by either approach. The four samples analysis identified six types of epithelial cells, as well as tumoral microenvironment populations. The scRNAseq results from epithelial neoplastic cells were concordant with common IHC markers. The proportion of immune cells identified by IHC in FFPE sections were similar to those obtained by scRNAseq. We identified and validated a previously poorly recognized subpopulation of neoplastic multi-ciliated cells (MCCs) (FOXJ1, ROPN1L). Analysis of FOXJ1 in 214 ER-positive invasive carcinomas demonstrated protein expression in one third of tumors, suggesting frequent focal MCC differentiation. Our results support the suitability of scRNAseq analysis using FFPE tissue, and identified a subpopulation of neoplastic MCC in breast cancer.
Understanding Caregivers’ Influence on Preschoolers’ Eating Behaviors: An Integrative Review Guided by the Theory of Planned Behavior
Authors: Oudat Qutaibah , Miller Elaine L. , Couch Sarah C. , Lee Rebecca C. , Bakas Tamilyn
Published: January 2025

Background/Objectives: Primary caregivers of children play a significant role in developing their dietary behaviors. Guided by the Theory of Planned Behavior (TPB), this integrative review aimed to synthesize studies examining how personal and household characteristics, caregivers’ dietary beliefs, intentions, and feeding practices influence the eating behaviors of preschool-aged children (2–5 years). Methods: PubMed, CINAHL, and PsycINFO databases were searched for peer-reviewed articles published between January 2014 and September 2024. The expanded PRISMA 2020 checklist was used to guide the literature search and report the results. The Johns Hopkins Nursing Evidence-Based Practice (JHNEBP) was also used to evaluate the quality of the selected articles. Results: A total of 10 studies were included in the final analysis. The studies revealed that preschoolers’ eating behaviors were significantly influenced by personal characteristics (e.g., caregivers’ BMI, and weight perceptions) and household factors (e.g., food availability). Additionally, caregivers’ feeding practices, such as restriction, modeling, and permissiveness, played a pivotal role in shaping children’s eating habits. Although caregivers expressed intentions to provide a healthy diet, they often faced barriers, including conflicting work schedules, financial constraints, and logistical challenges, which impeded their ability to consistently promote healthy eating behaviors. Conclusions: Caregivers’ beliefs, intentions, and feeding practices are pivotal in shaping preschoolers’ eating behaviors. However, the limited available literature and the underexplored mechanisms linking these factors make it challenging to draw solid conclusions. Future research should address these gaps and consider integrating caregiver-focused factors into tailored interventions to promote healthier eating habits in preschool-aged children. This can aid healthcare professionals in designing culturally and contextually sensitive strategies for improving childhood nutrition.
Severe Asthma in School-Age Children: An Updated Appraisal on Biological Options and Challenges in This Age Group
Authors: Indolfi Cristiana , Klain Angela , Capuano Maria Cristina , Colosimo Simone , Rapillo Renata , Miraglia del Giudice Michele
Published: January 2025

This review examines the growing role of biological therapies in managing severe asthma in children aged 6–11 years. Severe asthma, characterized by persistent symptoms and frequent exacerbations, presents significant challenges in pediatric care. Biologic treatments, including mepolizumab, omalizumab, and dupilumab, provide targeted interventions for patients with high eosinophilic inflammation or allergic asthma (T2-high asthma). Alongside their therapeutic benefits, the review evaluates the safety profiles of these biologics, highlighting potential side effects and the necessity for monitoring during long-term use. Cost considerations and treatment adherence also emerge as important challenges that need to be addressed in clinical practice. Additionally, the review emphasizes the need for identifying patients who would derive the most benefit from biologic therapies, advocating for the development of biomarkers to aid in treatment decisions. Emerging biologics, such as tezepelumab, are introduced as promising alternatives with the potential to target upstream inflammatory pathways, offering hope for treating T2-low asthma forms, which currently lack effective treatment options in children.
Implementation of Parenteral Nutrition Formulations with Increased Calcium and Phosphate Concentrations and Its Impact on Metabolic Bone Disease in Preterm Infants: A Retrospective Single-Centre Study
Authors: Sureshchandra Sushma , Maheshwari Rajesh , Nowland Tamara , Elhindi James , Rundjan Lily , D'Cruz Daphne , Luig Melissa , Shah Dharmesh , Lowe Gemma , Baird Jane , Jani Pranav R.
Published: January 2025

Background: Metabolic Bone Disease of Prematurity (MBDP) is common in extremely preterm infants (≤28 weeks gestation). Parenteral nutrition (PN) with higher calcium (Ca) and phosphorus (P) concentration started soon after birth may improve bone health in preterm infants. We compared the effect of two standard PN formulations on the incidence of MBDP and explored the predictive ability of biochemical markers for diagnosing MBDP. Methods: This retrospective study included eligible preterm infants ≤ 28 weeks gestation. Infants in group 1 (January 2016–December 2017) received PN 1 formulation with lower Ca (1.6 mmol/kg/day) and P concentration (1.4 mmol/kg/day). Infants in group 2 (June 2018–May 2020) received PN 2 formulation with higher Ca (2.3 mmol/kg/day) and P concentration (1.8 mmol/kg/day). We reviewed the biochemical and radiological investigations performed for diagnosing MBDP. Results: The incidence of MBDP reduced from 82.8% (77/93) in group 1 to 47.3% (27/57) in group 2. Grade 2–3 MBDP reduced significantly from 14% in group 1 to none in group 2 (p < 0.01). Serum phosphate < 1.5 mmol/L had a sensitivity of 79% and specificity of 77%, and alkaline phosphatase > 500 U/L showed a sensitivity of 72% and specificity of 71% for diagnosing radiological MBDP. There was no increase in hypercalcemia, hypophosphatemia or nephrocalcinosis from PN 2 formulation. Conclusions: A higher Ca and P concentration in PN reduced MBDP and eliminated grade 2–3 MBDP in our cohort without an increase in adverse events. Low serum phosphate and high serum alkaline phosphatase were the best predictors for diagnosing MBDP.
Photocatalytic Performance of Cementitious Composites Modified with Second-Generation Nano-TiO2 Dispersions: Influence of Composition and Granulation on NOx Purification Efficiency
Authors: Kalinowski Maciej , Chilmon Karol , Jackiewicz-Rek Wioletta
Published: January 2025

This study investigated the influence of the composition of photocatalytic dispersions made with second-generation nano-TiO2 on the air purification performance of photocatalytic cementitious composites. Nine mortar series were prepared, incorporating photocatalytic dispersions of variable content of nano-TiO2, dispersing agent (superplasticizer), and hydrophobic admixture. The total mass content of nano-TiO2 in investigated mortars was kept at the same level. For investigated composites, photocatalytic removal of NOx was evaluated under simulated laboratory conditions mimicking polish autumn/winter irradiation conditions. The results indicate that within the tested range of variability, the dispersion composition significantly influenced the granulation of the dispersed nano-TiO2 particles, which in turn affected the air purification performance of the composites. A predictive model was developed to account for environmental factors potentially influencing photocatalytic performance in urban environments. The model estimated that, depending on environmental conditions and photocatalytic dispersion composition, the composite’s photocatalytic layer could remove up to 1.067 g/m2 of NO2 per year in favorable environmental conditions. Photocatalytic cementitious composites can act as environmentally beneficial composites, contributing to carbon-negative construction practices and improving urban air quality. This highlights the dual benefits of offsetting embedded carbon emissions and enhancing air purification efficiency in sustainable urban infrastructure.
Oligometastatic NSCLC: Current Perspectives and Future Challenges
Authors: Torresan Sara , Costa Jacopo , Zanchetta Carol , De Marchi Lorenzo , Rizzato Simona , Cortiula Francesco
Published: January 2025

Oligometastatic non-small cell lung cancer (NSCLC) represents a separate entity with a different biology and prognosis compared to stage IV NSCLC. Challenges range from the very definition of oligometastatic disease to the timing and techniques of local treatments, and their benefit in prolonging patient survival. Most of the international consensus and guidelines agree on the need for shared criteria, such as appropriate stadiation and even tissue biopsy if needed, in order to select patients that could really benefit from personalised strategies. Multidisciplinary evaluation is crucial in order to define if every lesion is amenable to radical local treatment, which appears to be the most important criterion across different guidelines. A distinction must be made depending on the time of oligo-disease detection, separating de novo oligometastatic disease from oligorecurrence, oligoprogression and oligoresidual disease. These separate entities imply a different biology and prognosis, and treatment strategies consequently must be tailored. Locoregional approaches are therefore often contemplated in order to ensure the best outcome for the patient. In non-oncogene-addicted disease, the advent of immune checkpoint blockers (ICBs) allows physicians to take into consideration consolidative treatments, but timing, technique and subsequent systemic treatment remain open issues. In oncogene-addicted NSCLC, local treatments are nowadays preferably reserved to cases of oligoprogression, but the advent of new, more potent drugs might challenge that. In this review, we summarised the current knowledge, consensuses and data from retrospective and prospective trials, with the aim of shedding some light on the topic and emphasising the unmet clinical need.
New Mitogenomes of the Harnischia Generic Complex (Diptera: Chironomidae) and Their Implication in Phylogenetics
Authors: Liu Wenbin , Tang Yaning , Nie Jiaxin , Yan Haoran , Liang Wentao , Zhang Yanfei , Yan Chuncai
Published: January 2025

The Harnischia generic complex, a significant assemblage within the tribe Chi-ronomini, extensive global sampling and the integration of multi-characteristic data for comprehensive analysis are essential to elucidate the phylogenetic relationships within the Harnischia generic complex. We sequenced, assembled, and annotated the mitochondrial genomes of a single species each from the genera Parachironomus Lenz, Robackia Saether and Saetheria Jackson. Additionally, we incorporated 26 previously published mitogenomes into our analysis to delve deeper into the characteristics of these mitogenomes. Our findings indicate the close affinity between (Cryptochironomus + Demicryptochironomus) and (Harnischia + Microchironomus), aligning consistently with previous research outcomes showing that the Harnischia generic complex and Chironomus are phylogenetically close, and their clade forms a sister group with the Polypedilum generic complex. Based on mitochondrial genome data, Robackia is identified as the basal taxon being relatively primitive, with Parachironomus and Saetheria also appearing as primitive within the complex.
Rainfall Intensity–Duration–Frequency Curves Dataset for Brazil
Authors: Torres Ivana Patente , Cecílio Roberto Avelino , de Almeida Laura Thebit , Abreu Marcel Carvalho , da Silva Demetrius David , Zanetti Sidney Sara , Xavier Alexandre Cândido
Published: January 2025

This is a database containing rainfall intensity–duration–frequency equations (IDF equations) for 6550 pluviographic and pluviometric stations in Brazil. The database was compiled from 370 different publications and contains the following information: station identification, geographic position, size and period of the rainfall series used, parameters of the IDF equations, and literature references. The database is available on Mendeley Data (DOI: 10.17632/378bdcmnc8.1) in the form of spreadsheets and vector files. Since the launch of the Pluvio 2.1 software in 2006, which included 549 IDF equations obtained in the country, this is the largest and most accessible database of IDF equations in Brazil. The data provided may be useful, among other purposes, for designing hydraulic structures, controlling water erosion, planning land use, and water resource planning and management.
Classification of Chronic Obstructive Pulmonary Disease (COPD) Through Respiratory Pattern Analysis
Authors: Lee Do-Kyeong , Choi Jae-Sung , Choi Seong-Jun , Choi Min-Hyung , Hong Min
Published: January 2025

Background: This study proposes a classification system for predicting chronic obstructive pulmonary disease (COPD) patients and non-patients based on image and text data. Method: This study measured the respiratory volume based on thermal images, stored the respiratory data, and derived features related to respiratory patterns, including the total respiratory volume, average distance between expirations, average distance between inspirations, and total respiratory rate. The data for each feature were stored in text format. The four features saved as text were scaled using Z-score normalization and expressed as scores through weighted summation. These scores were compared to a threshold based on the ROC curve values, classifying participants as patients if the score exceeded the threshold and as non-patients if it fell below. Results: The proposed method achieved an accuracy of 82.5%. To validate the proposed approach, precision, recall, and F1-score were utilized, confirming the high classification performance of the model. The results of this study demonstrate the potential for future applications in non-contact medical examinations and diagnoses of respiratory diseases.
Amniotic Fluid and Maternal Serum Laeverin Levels and Their Correlations with Fetal Size and Placental Volume in Second Trimester of Pregnancy—A Prospective Cross-Sectional Study
Authors: Sikovanyecz János , Gullo Giuseppe , Vincze Márió , Földesi Imre , Németh Gábor , Surányi Andrea , Sikovanyecz János , Kozinszky Zoltan
Published: January 2025

Background: Laeverin is an extravillous trophoblast marker playing a significant role in trophoblast migration. We endeavored to estimate the association between the amniotic and serum laeverin concentrations at 16–22 weeks of gestation and the fetal and placental ultrasound measurements in high-risk uncomplicated pregnancies. Methods: A prospective cross-sectional study of consecutively recruited singleton pregnancies undergoing amniocentesis was performed. Fetal structural malformations and/or aneuploidy were the exclusion criteria. Fetal biometric parameters and placental growth/perfusion were assessed by ultrasound in 44 high-risk pregnancies who had no pregnancy complications and any other chronic disease. Maternal serum and amniotic laeverin levels were essayed with sandwich enzyme-linked immunosorbent assay. Results: Serum laeverin levels are decreasing marginally with the maternal age in mid-gestation. Laeverin levels in the serum correlated minimally negatively with head size of the fetus (β = −0.38; p < 0.05; 95% confidence interval (CI) −0.03–0.01), whereas the amniotic level correlated strongly with the fetal abdominal circumference (β = −0.74; p < 0.05; 95% CI: −0.34–−0.09). In addition, the amniotic laeverin level correlated moderately and positively with the placental volume (β = 0.46; p < 0.05; 95% CI: 0.01–0.08). Conclusions: Laeverin levels detected in the serum and in the amniotic fluid denote the fetoplacental growth in uncomplicated high-risk pregnancies.
Examining Impact of Inflation and Inflation Volatility on Economic Growth: Evidence from European Union Economies
Authors: Pappas Anastasios , Boukas Nikolaos
Published: January 2025

Examining the economies of the European Union from 2000 to 2023, we have found no strong evidence that the inflation rate has a negative impact on economic growth. In contrast, in line with conventional economic theory, higher interest rates are associated with lower economic growth. The results remain consistent even after controlling for various control variables, non-linearities and endogeneity issues. These findings suggest that an aggressive tightening of monetary policy in the euro area, aimed at rapidly bringing inflation under control, could actually be detrimental to economic growth. Since the negative effects of monetary tightening on growth are clear, while the benefits of rapidly reducing inflation on economic growth are ambiguous, the European Central Bank must be cautious about both the intensity and the duration of monetary tightening.
Navigating the Intersection of Microgrids and Hydrogen: Evolutionary Trends, Challenges, and Future Strategies
Authors: Indrajith Bawantha , Gunawardane Kosala
Published: January 2025

Growing interest in sustainable energy has gathered significant attention for alternative technologies, with hydrogen-based solutions emerging as a crucial component in the transition to cleaner and more resilient energy systems. Following that, hydrogen-based microgrids, integrated with renewable energy sources including wind and solar, have gained substantial attention as an upcoming pathway toward long-term energy sustainability. Hydrogen, produced through processes such as electrolysis and steam methane reforming, can be stored in various forms including compressed gas, liquid, or solid-state hydrides, and later utilized for electricity generation through fuel cells and gas turbines. This dynamic energy system offers highly flexible, scalable, and resilient solutions for various applications. Specifically, hydrogen-based microgrids are particularly suitable for offshore and islanded applications, with geographical factors, adverse environmental conditions, and limited access to conventional energy solutions. This is critical for energy independence, long-term storage capacity, and grid stability. This review explores topological and functional-based classifications of microgrids, advancements in hydrogen generation, storage, and utilization technologies, and their integration with microgrid systems. It also critically evaluates the key challenges of each technology, including cost, efficiency, and scalability, which impact the feasibility of hydrogen microgrids.
Fuel Injection Optimization for Large-Bore Two-Stroke Natural-Gas Engines
Authors: Banji Titilope Ibukun , Arney Gregg , Olsen Daniel B.
Published: January 2025

Recent methane emissions regulations present a challenge for the large-bore, natural-gas-fueled engines used at over 1700 compression stations across the US. Poor air–fuel mixing in the main combustion chamber of these engines results in low combustion efficiency and the resulting methane emissions. High-pressure fuel injection is believed to be a significant development in improving air–fuel mixing in natural-gas engine combustion chambers. This study aims to determine the sensitivity of in-cylinder mixing to injection pressures using Computational Fluid Dynamics (CFD) simulations, determine the limits of high-pressure fuel injection, and explore high-momentum low-pressure fuel injection. The engine, modeled using Converge Studio for CFD, was a Cooper-Bessemer large-bore, four-cylinder, GMV-4TF spark-ignited natural-gas engine with direct injection. The model was simulated for four sets of configured cases—baseline; ideal mixing; injection pressure variation; and low-pressure, high-momentum injection. The results show that fuel injection at 700 psi and −115 degrees BTDC gives the best in-cylinder mixing and improved mixing, potentially reducing methane emissions by half. The optimal timing for the injection at different injection pressures was determined. The level of mixing in low-pressure fuel-injection systems was also improved by the high-momentum fuel injector design. It was concluded that mixing can be further improved in integral gas compressor engines through fuel injection optimization.
A Comprehensive Review of Quality of Aquaculture Services in Integrated Multi-Trophic Systems
Authors: Ruiz-Vanoye Jorge A. , Diaz-Parra Ocotlan , Márquez Vera Marco A. , Fuentes-Penna Alejandro , Barrera-Cámara Ricardo A. , Ruiz-Jaimes Miguel A. , Toledo-Navarro Yadira , Bernábe-Loranca María Beatríz , Simancas-Acevedo Eric , Trejo-Macotela Francisco R. , Vera-Jiménez Marco A.
Published: January 2025

The concept of Quality of Aquaculture Services (QoAS) is inspired by the Quality of Service (QoS) principle, originally developed in the field of networks and telecommunications, where it refers to the ability to guarantee the quality, availability, and priority of service in a communications system. Adapted to the aquaculture context, QoAS is fundamental to maximising the benefits of Integrated Multi-Trophic Aquaculture (IMTA). IMTA has emerged as a sustainable approach to meet the growing global demand for aquatic food products by combining species from different trophic levels in a single system, optimising resource use, improving environmental performance, and diversifying production. However, ensuring QoAS in these complex systems requires the implementation of advanced technologies to monitor, manage, and optimise every aspect of the aquaculture process. This article presents a comprehensive review of technologies applied at IMTA, focusing on IoT-based monitoring systems, resource management algorithms, water recirculation technologies, intelligent automation, biosecurity, and data management platforms. Our review finds that IoT and automation-based solutions significantly enhance real-time monitoring, increasing operational efficiency and environmental sustainability. Key challenges identified include integration complexity, high costs, and technical expertise requirements, but the ongoing development of modular, user-friendly solutions indicates a promising trajectory. This review highlights the transformative role of technological innovation in IMTA, providing a foundation for future research and advancements in QoAS management in aquaculture.
Variations of Length–Weight Relationships for Six Fish Species from the Lower Yarlung Zangbo River Catchment, Tibet, China
Authors: Ding Huiping , Xiong Mantang , Yang Yang , Zhong Tian , Chen Feng , Gong Yutian , Zhang Dongya , Jiang Sijin , Zhang Zhiming
Published: January 2025

The lower reaches of the Yarlung Zangbo River are one of the most important biodiversity hotspots worldwide. With the rapid economic development in the area coupled with global climate change, the fish resources and diversity of this region are experiencing serious threats. Basic biological information on most fishes in the river is limited, restricting the conservation of local fish resources. This study aimed to provide estimates of length–weight relationships (LWRs) for six fish species from the lower Yarlung Zangbo River catchment, Tibet, China. From 2023 to 2024, 4034 specimens belonging to two families, five genera, and six species were collected using various types of fishing techniques. The LWRs of five species, namely Schizothorax curvilabiatus, Schizothorax molesworthi, Pseudecheneis sulcata, Parachiloglanis hodgarti, and Exostoma labiatum were reported for the first time to FishBase, except Garra tibetana. The b values calculated from the LWRs ranged between 2.738 and 3.172, and the r2 values for all LWRs estimates ranged from 0.931 to 0.989. Sexual variations of LWRs were observed in S. molesworthi and P. sulcata; seasonal variations were detected in S. curvilabiatus, S. molesworthi, G. tibetana, P. sulcata, and P. hodgarti; and geographical differences were discovered in S. molesworthi, G. tibetana, P. sulcate, P. hodgarti, and E. labiatum. Additionally, this study updated information for FishBase by providing a new record of maximum standard length for S. curvilabiatus, S. molesworthi, G. tibetana, and P. hodgarti and a new record of total length for P. sulcata. The findings of this study are essential for the management and conservation of locally indigenous fish and fisheries.
Effects of Substituting Wheat with Waxy Barley Bran Flour on Physical Properties, Health Functionality, and Sensory Characteristics of Noodles
Authors: Tsurunaga Yoko , Uno Ayane , Takahashi Tetsuya , Furuichi Tsugumi
Published: January 2025

When waxy barley (WB) is milled, 40% of the weight is typically discarded as bran. To utilize WB bran resources and improve health functionality, flours prepared from inner bran (IB) and outer bran (OB) layers were used to substitute partially wheat all-purpose flour (APF) for noodle preparation. The dough and noodle qualities were investigated based on analytical tests and sensory evaluations. Both methods revealed considerable darkening of the doughs and noodles upon OB substitution. Boiled noodles with 30% and 50% IB substitution had considerably lower total energy and breaking stress, whereas those with OB substitution had higher breaking stress at all substitution rates. Texture differences between sample groups were observed using analytical tests, but not via sensory evaluation. In addition, the boiled noodles with 50% OB demonstrated considerably lower taste preference in the sensory evaluation than the APF noodles. The comprehensive evaluation score was considerably lower for the boiled noodles with 30% or 50% OB than that of the APF noodles. The β-glucan and antioxidant contents increased with the IB or OB substitution rates. These findings show that APF can be substituted with IB at a substitution rate of 50%, while the substitution of OBF is limited to ≤10%.
Beyond the Demands of Integration: African Refugee Resettlement in Contemporary Multicultural Australia
Authors: Openshaw Kathleen , Atem Atem , Phillips Melissa
Published: January 2025

This paper uses the example of negatively racialised refugees from the African continent to reiterate the racialised nature of migrant and refugee experiences in Australia. This is a context that remains deeply influenced by a violent history of British colonisation and racist migration laws, including the restrictive White Australia Policy (1901–1973). Drawing on the authors’ research and personal experiences of working with, and navigating, the Australian resettlement system this article examines the racialised violences inherent in expectations of ‘integration’ for (former) African refugees in a settler colonial country. This paper proffers a principle level re-imagining of refugee resettlement in Australia that challenges patriarchal white sovereignty. It proposes a meaningful consideration of resettlement practices that are community-led, localised, relational and that recognise the agency of refugees who settle in Australia. This paper disrupts dominant tropes of refugees as perpetually vulnerable and deficit, by centering the agency, needs and expectations of a good life as it is lived in community, rather than dictated by the state.
A Geographical Complementary Approach to Unveiling the Spatial Dynamics of Bradyseismic Events at the Campi Flegrei Caldera
Authors: De Falco Stefano , Martino Claudio
Published: January 2025

Concerning the monitoring of the resumption of seismic activity at the Campi Flegrei caldera, which is causing concern to the inhabitants and involving various protection efforts by research bodies, this work intends to constitute a complementary and auxiliary tool with respect to the geophysical studies in progress. In particular, a geographical analysis of the phenomenon is proposed here aimed at identifying any spatial dynamics that can be added to the interpretation of seismic activity in a strictly geological and geophysical manner. The research study is focused on the comparison between the historical series of data starting from the year 2005 and those data relating to the last two years 2023 and 2024, in which the phenomenon resumed; particularly, the month of May 2024 is analyzed, which was characterized by high intensity of seismic events in the area. The results obtained through the joint use of spatial analysis tools aim, therefore, to identify any geographical seismic clusters that can then be interpreted in a geophysical way and can be used as an addendum in the current risk maps. Indeed, this geographical approach revealed complex spatial heterogeneities demonstrating the value of combining multiple methodological tools. The findings highlight the importance of multidisciplinary approaches in volcanic research and their critical role in improving hazard assessment and risk mitigation efforts.
Comparative Self-Evaluation of Patient Education Practice: A Study of Novice and Experienced Physiotherapists
Authors: Grbavac Vedrana , Naletilić Mladenka , Šimić Josip , Forbes Roma
Published: January 2025

Background: Patient education is a key aspect of physical therapy practice; however, the differences in how experienced and novice physiotherapists perceive and apply patient education practice remain underexplored. Understanding these differences influences training approaches and improves physical therapy practice quality. This research aims to determine the difference in self-reported patient education practice between experienced and novice physiotherapists. Methods: A previously published online survey instrument was used to collect data from physiotherapists employed in public health institutions in Bosnia and Herzegovina. The survey questions included demographic characteristics and questions about approaches to patient education, perceived importance, and factors contributing to skills development. Participants were recruited in two groups: experienced physiotherapists with work experience ≥ 11 years (n = 139) and novice physiotherapists with work experience ≤ 5 years (n = 45). Descriptive statistics, such as numbers and percentages, were used to summarize participant responses. Results: Experienced physiotherapists more frequently provided advice on posture, movement correction, daily activity strategies, and pacing while addressing patient concerns and exploring perceptions (p < 0.05). In contrast, novice physiotherapists placed significantly greater value on continuing education courses, considering them an important factor in developing patient education skills (p < 0.05). Conclusions: Experienced physiotherapists prioritize patient education focusing on posture, movement, and self-care strategies compared to novice physiotherapists. However, novice physiotherapists place a higher importance role on continuous education. Identifying these differences may help tailor training and mentorship to improve physiotherapy practice, ensuring better patient outcomes.