bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PENGGUNAAN MAGIC FORMULA DALAM PORTOFOLIO INVESTASI
Authors: Audini Mika , Dewi Dian Masita
Published: November 2022

ABSTRACT
This research is purposed to know the investment performance by using Magic Formula which is introduced by Joel Greenblatt (2006). The population in this research are 58 companies which fulfill the criteria by the sample of 48 companies which is obtained by using the purposive sampling. Magic formula is the selection strategy of simple stock by ranking the stock based on return of capital (ROC) and earning yield (EY). Portfolio is formed by choosing the top thirty stock from the total rank.  This research is comparing the average of return and risk of magic formula in market. Rebalancing portfolio is done every year. Sharpe inddex, Treynor, and Jensen is used to measure the performance of portfolio adepted by risk. Overall, the results of this study showed that the average return Magic Formula of return (7.87%) surpassed the two reference indices of Indonesia Composite Index (IHSG) (6.32%) and Kompas100 (5.54%) during the tested period. A higher return magic formula produced a higher risk. The results of portfolio performance measurement revealed that the Sharpe Index of Magic Formula has lower performance than market performance. Meanwhile, based on the Treynor and Jensen index, the portfolio formed by the Magic Formula can surpass the market performance.
Keywords :  Investment Strategy, Magic Formula , Return on Capital, Earning Yield
 
ABSTRAK
Penelitian ini bertujuan untuk mengetahui kinerja investasi dengan menggunakan Magic Formula yang diperkenalkan oleh Joel Greenblatt (2006). Populasi dalam penelitian ini adalah perusahaan yang memenuhi kriteria berjumlah 58 perusahaan dengan sampel penelitian berjumlah 48 perusahaan yang diperoleh dengan menggunakan purposive sampling. Magic formula adalah strategi pemilihan saham sederhana dengan cara memeringkatkan saham berdasarkan return on capital (ROC) dan earning yield (EY). Portofolio dibentuk dengan memilih tiga puluh saham teratas dari total peringkat. Penelitian ini membandingkan rata-rata return dan risiko magic formula dengan pasar. Rebalancing portofolio dilakukan tahunan. Indeks Sharpe, Treynor dan Jensen digunakan untuk mengukur kinerja dari portofolio yang disesuaikan dengan risiko.  Secara keseluruhan, penelitian ini menunjukkan bahwa tingkat rata-rata return Magic Formula (7.87%) mengungguli kedua indeks acuan yaitu IHSG (6.32%) dan Kompas100 (5.54%) selama periode yang diuji. Return Magic Formula yang lebih tinggi menghasilkan risiko yang lebih tinggi pula. Hasil pengukuran kinerja portofolio menunjukkan bahwa dengan Indeks Sharpe dari Magic Formula memiliki kinerja yang lebih rendah dibanding kinerja pasar. Sedangkan dengan menggunakan Indeks Treynor dan Jensen, portofolio yang dibentuk dari Magic Formula dapat mengungguli kinerja pasar.
Kata kunci : Strategi Investasi; Magic Formula; Return on Capital; Earning Yield
PENGARUH WORK-FAMILY CONFLICT (WFC) DAN WORKPLACE STRESS (WPS) TERHADAP BURNOUT DENGAN PERCEIVED SUPERVISOR SUPPORT (PSS) SEBAGAI VARIABEL MODERASI (Studi Pada Perawat Perempuan RSUD ULIN Banjarmasin di Ruangan ICU, IGD dan Hemodialisa)
Authors: Oetoyo Devi Anita Filayanti
Published: November 2022

This research aims to find out and analyze the influence of work-family conflict on burnout, the influence of workplace stress on burnout, the influence of perceived supervisor support on burnout, the role of perceived supervisor support on the influence of work-family conflict on burnout, and the role of perceived supervisor support on the influence of workplace stress on burnout in female nurses at Ulin Hospital Banjarmasin in the ICU, IGD and Hemodialysis Room.
This research is quantitative research with an explanatory research approach. This research method uses a questionnaire with 86 populations, and all of them were determined as samples as respondents. The measurement of variables used Interval Scale and Likert Scale technique with the weights scale from 1 to 5. The data were analyzed using Partial Least Square (PLS). The results of this indicated that (i) there was a significant positive influence of work-family conflict on burnout, (ii) there was a significant positive influence of workplace stress on burnout, (iii) there was a significant positive influence of perceived supervisor support on burnout, (iv) there was a significant negative influence of perceived supervisor support as the moderating variable on the influence of work-family conflict on burnout, and (v) there was a significant positive influence of perceived supervisor support as a moderating variable on the influence of workplace stress on burnout.
Keywords : Work-Family Conflict, Workplace Stress, Perceived Supervisor Support, Burnout
TAX PLANNING DAN NILAI PERUSAHAAN (STUDI PADA PERUSAHAAN PERTAMBANGAN DI BEI TAHUN 2016-2018)
Authors: Juliati Juliati , Rahmawati
Published: November 2022

Aggressive tax planning has an impact on reducing the amount of taxes that must be paid to the state. Several mining companies in Indonesia are indicated to carry out aggressive tax planning. By using signal theory, companies that carry out tax planning can have an impact on decreasing the value of the company because the company is indicated to have violated tax regulations. This study will examine whether the tax planning by the company has a negative effect on the company. The research design used is quantitative research using hypotheses. The hypothesis proposed is that tax planning has a negative effect on firm value. Hypothesis testing using multiple linear regression. The research sample used is a mining company that went public on the Indonesia Stock Exchange (IDX) in 2016 – 2018. The independent variable is tax planning while the dependent variable is company value, this study also uses control variables, namely profitability and leverage. Measurement of tax planning by using the effective tax rate (ETR) and ETR differential, while the value of the company is measured by using the price to earnings ratio (PER). Profitability control variable is measured using return on assets (ROA) and leverage is measured using debt to equity ratio (DER). The results show that the smaller the ETR, the smaller the PER of the company. The larger the ETR differential, the smaller the PER of the company. The smaller the ETR or the larger the ETR differential indicates that the more aggressive the tax planning is carried out by the company and the greater the tax planning will have an impact on decreasing the value of the company so that the hypothesis in this study is accepted. The conclusion of this study is that tax planning that is carried out aggressively by the company can potentially violate tax regulations applied by a country so that this policy can affect the value of the company to be down.Keywords: tax planning, firm value
User requirements and interface design for collaboration research applications using user experience design process
Authors: Batubara Abdul Karim , Purwaningtyas Franindya , Putri Raissa Amanda
Published: November 2022

In conducting collaborative research involving more than one researcher, a system is needed that can improve the performance of researchers in various ways. This study captures the challenges faced by researchers in collaborative research and defines the requirements for collaborative research systems needed to address these challenges. From the analysis of the needs obtained, the researchers designed a collaboration application interface. Collaboration applications are needed to facilitate communication between researchers, search for articles, share publications, and other applications. The distribution of questionnaires and interviews were conducted to obtain the requirements needed for the development of a collaboration system. This research informs system developers to support the development of collaborative systems. In this study, the level of need for a research collaboration system in the university environment will be analyzed along with an analysis of its needs and the design of the user interface.
Physicochemical, Morphological and Cytotoxic properties of Brazilian Jackfruit (Artocarpus Eterophyllus) Starch Scaffold loaded with Silver Nanoparticles
Authors: Rodrigues José Filipe Bacalhau , Azevedo Valeriano Soares , Medeiros Rebeca Peixoto , Barreto Gislaine Bezerra de Carvalho , Pinto Maria Roberta de Oliveira , Fook Marcus Vinicius Lia , Montazerian Maziar
Published: November 2022

Starch is a widespread natural polymer used in healthcare applications due to its low cost and antibacterial properties. The use of starch in its many forms and its sometimes combination with metallic nanoparticles have all contributed to the advancement of biomaterials. However, few studies have been conducted on biocomposites composed of jackfruit starch and silver nanopar-ticles (AgNPs). As a result, this research aims to study the physicochemical, morphological, and cytotoxic features of a Brazilian jackfruit (Artocarpus heterophyllus) starch-based scaffold loaded with AgNPs. Gelatinization and chemical reduction were used to synthesize the scaffold and AgNPs, respectively. X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy coupled with energy-dispersive spectroscopy (SEM-EDS), and Fourier transform infrared spectroscopy (FTIR) were utilized to explore the properties. The findings supported the development of anisotropic, stable, monodispersed AgNPs. The presence of AgNPs in the scaffold matrix was revealed by XRD and SEM-EDS. AgNPs were found to modify the crystallinity, roughness, and thermal stability of the scaffold while leaving its chemical and physical characteristics unchanged. Finally, the scaffolds did not show adverse effects on the L929 cells.
Quantitative Proteomics Approach to Characterize Cellular Reprogramming
Authors: Hovey Owen , Zhong Shanshan , Kaneko Tomonori , Li Shawn , Ezra Sally
Published: November 2022

Tandem mass tag (TMT)-based proteomics facilitate multiplexing in mass spectrometry (MS)-based quantification and identification of proteins and their post-translational modifications. The use of TMT isobaric tags can enable multiplexing of up to 18 samples using commercially available kits. A single TMT experiment can quantify proteome, serine, threonine phosphorylation, and tyrosine phosphorylation. Of note, tyrosine phosphorylation is of low abundance, and identification/quantification can be improved using two complementary strategies. First, by employing SH2 superbinder which increases the number of identified sites. The SH2 Superbinder is more cost-effective than the commonly used phosphotyrosine antibodies. Second, by employing phosphotyrosine booster strategy, a pervanadate-treated channel to boost the signal of low-abundant phosphotyrosine. Noteworthy, pervanadate boost increases the likelihood of low abundant peptide to be selected for MS2, and facilitating the detection of > 6000 proteins, 10,000 unique pS/T and 1000 unique pY sites.
Microbial Consortium Applications Can Affect Quality and Primary Metabolism of Processing Tomato
Authors: Fusco Giovanna Marta , Burato Andrea , Pentangelo Alfonso , Cardarelli Mariateresa , Nicastro Rosalinda , Carillo Petronia , Parisi Mario
Published: November 2022

Microbial-based biostimulants containing arbuscular mycorrhizal fungi (AMF), Trichoderma fungi and plant growth-promoting rhizobacteria (PGPR) have been applied in an open-field tomato cultivation. A two-years field experiment (2020-2021) was performed in Southern Italy on “Heinz 1534” processing tomato hybrid, using three commercial formulations characterized by different microbial consortia (MIC: Glomus spp., Rhizophagus spp., Bacillus spp., Streptomyces spp., Pichia spp., Trichoderma spp.; EKO: Glomus spp., Bacillus spp., Streptomyces spp., Pseudomonas spp., Arthrobotrys spp., Monacrosporium spp., Paecilomyces spp., Myrothecium spp., Trichoderma spp.; FID: Glomus spp., Bacillus spp., Trichoderma spp.) and comparing them to untreated control (CTRL). The effect of growing season and microorganism-based treatments on yield, technological traits and functional quality of tomato fruits was assessed. The year of cultivation (Y) affected yield (with lower fruit weight, higher marketable to total yield ratio and higher % of total defected fruits in 2020), and technological components (higher dry matter, total acidity, total soluble solids in 2020). During the first year of the trial, all evaluated treatments (MIC, EKO and FID) enhanced soluble solids content by 10%, on average, compared to CTRL. Sucrose and lycopene contents were influenced both by the microbial-based treatments and the growing season (greater values found in 2021 with respect to the first year). Y factor also significantly affected all evaluated metabolites contents, except for tyrosine, essential (EAA) and branched-chain (BCAAs) amino acids. Over two years of field trial, FID biostimulant enhanced the contents of proteins (+53.71%), alanine (+16.55%), aspartic acid (+31.13%), γ-aminobutyric acid (+76.51%), glutamine (+55.17%), glycine (+28.13%), monoethano-lamine (+19.57%), total amino acids (+33.55), essential amino acids (+32.56%) and branched-chain amino acids (+45.10%) compared to the untreated control. Our findings highlighted the valuable effect of FID microbial inoculant in boosting several primary metabolites (proteins and amino acids) in the fruits of processing tomato crop grown under Southern Italy environmental condi-tions, although no effect on yield and its components was appreciated.
Chloroplast Genetics Engineering: from Bench to Blast Application of Chloroplast Genetic-Engineering in Basic Research
Authors: Wang Bo
Published: November 2022

Abstract: Chloroplast is a new hotspot in the field of plant transformation system of plant genetic engineering. Initially developed in Chlamydomonas and tobacco, it is now feasible in a broad range of species. They exploit the homologous recombination and segregation pathways acting on chloroplast genomes and are based on direct repeats, transient co-integration or co-transformation and segregation of trait and marker genes. Foreign site-specific recombinases and their target sites provide an alternative and effective method for removing marker genes from plastids.Chloroplast genetic engineering has many advantages over nuclear genetic enginering, especially site-specific introduction of foreign genes ,leading to the absence of gene siliency and positon effect,which providing the available to explore the regulation and mechanism of chloroplast genes`expression in vitro .It also can identify the structure and function of the chloroplast genome , the expression of chloroplast affect the nulear genome. In this paper, the basic methodology of chloroplast transformation, the current techniques and applications, and the future possibilities for Chloroplast genetic engineering was reviewed[1-3].
Biothermodynamics of Viruses from Absolute Zero (1950) To – Virothermodynamics (2022)
Authors: Popovic Marko
Published: November 2022

Biothermodynamics of viruses is among the youngest, but rapidly developing scientific disciplines. During the COVID-19 pandemic, it has closely followed the results published by molecular biologists. Empirical formulas were published for 50 viruses and thermodynamic properties for multiple viruses and virus variants, including all variants of concern of SARS-CoV-2, SARS-CoV, MERS-COV, Ebola virus, Vaccinia and Monkeypox virus. A review of development of biothermodynamics of viruses during the last several decades and intense development during the last 3 years has been described in this paper.
Determining Criteria for Supplier Selection in the Indonesian Oil and Gas Industry
Authors: Habibah Nur , Kusumastuti Ratih Dyah
Published: November 2022

"Research Aims - This research aims to identify the main criteria of supplier selection in the oil and gas industry in Indonesia and their causal relationships by using the DEMATEL method. Methodology - Based on the literature review and discussions with experts, ten supplier selection criteria were identified and used as the basis of questionnaire development. The questionnaire was distributed to 57 respondents representing supply chain management and other divisions in eight oil and gas companies in Indonesia, with 51 valid responses. The data was analyzed using the DEMATEL method. Research Findings - The results show that product price is the most important criterion, while technical ability was the least important criterion. Moreover, six criteria (product quality, product price, technical ability, service, production capability, and financial situation) were identified as the cause criteria and require more attention compared to the other four effect criteria (delivery performance, stable delivery of goods, lead time, and reaction to demand change in time). Theoretical Contribution/Originality - The research provides insights on the important criteria of supplier selection in oil and gas companies in Indonesia and their causal relationships. Managerial Implications in the Southeast Asian Context - The results can be used by oil and gas companies to better select their suppliers. Research Limitations and Implications - This study uses a non-stratified sample from eight oil and gas companies in Indonesia, which may not accurately represent the Indonesian oil and gas industry."
Cold regions vehicle start : next-generation lithium-ion battery technologies for Stryker vehicles
Authors: Trubac Kathryn , Reynolds Randall , Cooke Timothy , Hartshorn Caylin , Punt Douglas , Donnelly Christopher , Callaghan, Caitlin
Published: November 2022

Operating vehicles in extremely cold environments is a significant problem for not only the public but also the military. The Department of Defense has encountered issues when trying to reliably cold start large, heavy-duty military vehicles, specifically the M1126 Stryker Combat Vehicle, in cold regions. As noted in previous work, the issue stems from the current battery technology’s limited temperature range. This current project utilized the protocol established in the previous phase to evaluate next-generation lithium-ion battery technologies for use in cold regions. Selected battery technologies met necessary military specifications for use in large military combat vehicles and were evaluated using a mechanical load system developed in previous work to simulate the starting of a Stryker engine. This work also evaluated the performance of the existing battery technology of a Stryker under Alaskan winter temperatures, which will verify the accuracy of the simulated cold room testing on the mechanical load system. The results of the tests showed that while the system was able to reliably operate down to −20°C, the battery management system encountered challenges at the lower end of the temperature range. This technology has a potential to reliably support cold regions operations but needs further evaluation.
Implementation of conservation farming and its effect on farmers' income: A study on citrus farmers in Petung Sewu Village, Dau District, Malang Regency
Authors: Asnah Asnah , Melfinsius Pati Huka , Cakti Gunawan Indra
Published: November 2022

This study aims to analyze the effect of applying vegetation and mechanical conservation on the income of citrus farmers. The method of determining the sample was simple random with a sample of 86 people. Data analysis used the income function model with multiple linear regression method. The results showed that the application of conservation that had a significant effect on income was the application of vegetation conservation, while other variables that had a significant effect were land area, plant maintenance costs, chemical fertilizer costs, pesticide costs and labor costs. The vegetation conservation is the best conservation, and profitable that is widely applied by farmers. This model has a significant effect on farmers' income with a significance level of 90 percent. Thus, the application of conservation adapts to land conditions, and increases the income of linear farmers with the ability of farmers to finance.
Translation Methods and Procedures Found in the Harry Potter: the Chamber of Secrets Movie Subtitle
Authors: Usmany Clarence
Published: November 2022

While doing translation process several methods and procedures needed to be understood. This article focused on finding out the method and procedures proposed by Newmark (1988) done by the translator in order to tackle problems in translation.This article entitled “Translation Methods and Procedures Found in the Harry Potter: the Chamber of Secrets Movie Subtitle” were taking data randomly from two version of the movie subtitles “Harry Potter and The Chamber of Secrets.” The data taken were 5 phrases from each version of the subtitle that were collected with documentation methods. The data then analyzed by using descriptive qualitative method. The theory in this study used “A Textbook of Translation” written by Newmark (1988). Translation methods discovered are faithful translation, free translation, idiomatic translation, and communicative translation. Meanwhile, the procedure that were found are synonymy, cultural equivalent, functional equivalent, and modulation. The differences in both target and source language are sometimes philosophical hence making it beneficial to apply the correct methods and procedures. Moreover, not applying a correct methods and procedures can end up altered the actual meaning of the word and or not being able to find the closest equivalent meaning of the word. Therefore, a method and procedures all compiled by Newmark are the epicentrum of every translator in doing their job, the total awareness of each particular methods and procedures are expected to help translator to translates word without losing, altered, or shifting the correct contextual meaning.
On The Profiling of Air Leakage Infiltration Pattern across Chinese Vernacular Buildings
Authors: Egwunatum Samuel I. , Akpezi Udubra E. , Otasowie Osamudiamen K. , Awodele Imole A.
Published: November 2022

The purpose of this paper is to provide understanding on the seasonal pattern of air leakage (infiltration) in Chinese Vernacular buildings across China’s five climate regions. In achieving the set purpose, a grand extensive literature survey was conducted and supported with data drawn from established Meteonorm V6.1 on sensible heat and psychrometric variables. Numerical computations for normalized and specific infiltration from stack effects followed the Gowri method in line with ASHRAE reference 2004. Solar energy admittance into building followed the Bouger’s Model form Angstrom properties. From the distribution of vernacular buildings across five climate regions of China, evidence from computational and numerical values showed symmetries in terms of minimums and maximums times of occurrence. Further, a reciprocal pattern exists between solar radiative admittance and region’s temperature profile. Knowing that Chinese vernacular building heritage extended to further Asia, this research became limited to only Chinese region. It became difficult to report if the construction culture away from China have correlation with infiltration and energy admittance value. Earlier works on Chinese climate and vernacular dwellings reported a climate responsive dwelling design by passive cooling strategy; a gap was closed by extending the previous work to specific infiltration pattern and energy admittance level. Chinese vernacular buildings by virtue of research outcome are and should be adoptable to modern housing needs for cultural integration.
Carbon nanoparticles induce DNA repair and PARP inhibitor resistance associated with nanozyme activity in cancer cells
Authors: Fan Haiyan , Sun Qinglei , Dukenbayev Kanat , Benassi Enrico , Manarbek Limara , Nurkesh Ayan A. , Khamijan Medina , Mu Chenglin , Li Guoliang , Razbekova Madina , Chen Zhenbang , Amin Amr , Xie Yingqiu
Published: November 2022

Background
Quantum nanodots especially carbon nanoparticles (CNPs) have been widely studied in biomedicine in imaging, drug delivery, but anti-cancer mechanisms remain elusive.
Methods
Here we studied on a type of cell death induced by food (beet, soybean) derived CNPs in cancer cells and tested whether CNPs induced DNA damage and resistant to anticancer agent PARP inhibitor (PARPi) could be overcome by quantum calculation, SEM, TEM, AFM, FT-IR, soft agar assay, and cytotoxicity assay.
Results
At high doses, CNPs derived from beet lead to a pop-like apoptosis of cells. Quantum mechanical calculation confirmed CNPs binding with phosphate groups as well as DNA bases. At low doses, CNPs develop PARPi drug resistance through interactions between CNPs and PARPi. A synergistic drug effect was achieved with the combination of phosphatase inhibitor (PPi), PARPi and CNPs. This is corroborated by the fact that a sulfur modulated CNPs which exhibit super high phosphatase nanozyme activity abrogated the CNPs induced colony formation in anchorage-independent cancer cell growth.
Conclusion
Thus, our data suggest the CNPs intrinsic nanozyme activity of phosphatase may crosstalk with drug resistance, which can be reversed upon modulations.
Effects and parameters of community-based exercise on motor symptoms in Parkinson's disease: a meta-analysis
Authors: Yang Chun-Lan , Huang Jia-Peng , Wang Ting-Ting , Tan Ying-Chao , Chen Yin , Zhao Zi-Qi , Qu Chao-Hua , Qu Yun
Published: November 2022

Background Community-based exercise is a continuation and supplement of Parkinson's hospital rehabilitation and is a type of unsupervised exercise. The effects, parameters, and forms of each study were diverse. The effect is affected by many factors. In this paper, a Meta-analysis was conducted to determine the effect and the best parameters for improving motor symptoms and explore the possible factors affecting the effect. Methods We conducted a comprehensive search of six databases: PEDro, PubMed, CENTRAL, Scopus, Embase, and WOS. Studies comparing community-based exercise with usual care were included. The intervention mainly included dance, Chinese martial arts, Nordic walking, and home-based exercise. The primary outcome measure was the Unified Parkinson’s Disease Rating Scale part III (UPDRS-III). Mean difference (95% CI) was used to calculate treatment outcomes of continuous outcome variables, and I2was used to estimate the heterogeneity of the statistical analysis. We conducted subgroup analysis and meta-regression analysis to determine the optimal parameters and the most important influencing factors of exercise effect. We previously registered the proposal of the meta-analysis on the PROSPERO website (NO. CRD42022327162) and strictly reported it according to PRISMA's stated terms. Results Twenty-two studies enrolling a total of 809 subjects were included in the analysis. Exercise had a positive effect on UPDRS-III (MD= -5.83; 95% CI, -8.29 to -3.37), Timed Up and Go Test (MD= -2.22; 95% CI -3.02 to -1.42), UPDRS ((MD= -7.80; 95% CI -10.98 to -6.42), 6-Minute Walk Test (MD = 68.81; 95% CI, 32.14 to 105.48), and Berg Balance Scale (MD = 4.52; 95% CI, 2.72 to 5.78). However, the heterogeneity of each study included was obvious. Weekly frequency, age, and location are all factors potentially affecting the effect. Conclusions This meta-analysis suggests that community-based exercise may benefit motor function in patients with PD. The most commonly used modalities of exercise are Tango and Tai Chi, and The most common prescription is 60 minutes twice a week. Future studies should consider the influence of age, region, and weekly frequency on the effect.PROSPERO trial registration numberCRD42022327162.
RNN-Fuzzy-c-means-smote and fuzzy classifier to early predict hidden disease
Authors: Roudani Mohammed , Moutaouakil Karim El
Published: November 2022

Unbalanced dataset classification issues have been prevalent in medical domain. Lately, clustering-based oversampling techniques were introduced to address this issue. Regrettably, they suffer from the vulnerability of hard grouping approaches. This paper introduces Recurrent Neural Network Fuzzy-C-Means SMOTE (RNNFCM-SMOTE) that balances data based on Recurrent Neural Network Fuzzy Fuzzy-C-Means in filtering phase. First of all, to manage the sensitiveness of the hard clustering, RNNFCM is used to determine safe regions. Second, take benefit of the capacity of neural networks to comprehend the features of data and dynamic systems to recover from past clusters, recurrent neural network is implemented to determine the membership function of different instances. To generate artificial data, classical smote is used. As the methods implementing fuzzy logic have proven to be very competent when it comes to the edge problem, RNNFCM-SMOTE is combined to nine fuzzy classifier methods to predict the existence of hidden diseases represented by five unbalanced medical data sets. The proposed method is compared to 12 oversampling methods using three performance measures. RNNFCM-SMOTE has been shown to consistently exceed many other popular oversampling techniques
Comparison of Climate Change Impact upon Water Productivity of Winter Wheat in Northern and Southern Regions of Iraq
Authors: Hasan Ban Flaieh , Abed Basim Sh.
Published: November 2022

Maximizing the water productivity for any agricultural system is considered an adaptation to the potential climate change crisis. It is required, especially in arid and semi-arid environments in Iraq. Therefore, this study assessed the potential impact of climate change on the different environments in the Qadissiya and Nineveh provinces. The ensemble of six GCM models employed for the regional climate model of the HCLIM-ALADIN in high-resolution 10*10 km2 and Aqua-Crop was used to examine the response of water productivity and yield of winter wheat. With and without CO2 concentration changing under different water regimes in the near term (2020-2040) and mid-term (2041-2060) related to the reference period (1995-2014). The model was validated in both provinces to indicate good performance of RRMSE (4.54- 7.1) and d, R2 ( 1- 0.99). The main findings revealed an increase in water productivity, yield production, and transpiration reduction under the CO2-changing scenario and behaved stable under the fixed concentration scenario. The developed schedule enhanced water productivity in both locations. The assessment study examined the resilience of arid and semi-arid agricultural lands under future climate change.
A Modified Two-step Technique for the Retrieval of a Chemoport Catheter Fragment With Inaccesible Ends
Authors: Sokwalla Naushad Karim , Sagoo Ravjit , Moussa Alel , Mansour Manel
Published: November 2022

BACKGROUND
Migration of central venous catheters is a rare but serious complication. The endovascular approach has been widely used for the retrieval of such fragment, with the two-step technique used for removal of catheter fragments with inaccessible ends. In this case report, we describe a modification of this technique that was used after first attempting the two-step technique unsuccessfully.
CASE PRESENTATION:
A 42-year-old female with breast cancer had a chemoport inserted for chemotherapy. After 6 cycles of chemotherapy the port could not be flushed and a chest radiograph demonstrated a migrated catheter fragment. CT scan demonstrated that one end of the fragment was in the liver in the middle hepatic vein and the other in the right atrial appendage. A modified 2 step technique, using a pigtail catheter, hydrophilic wire and snare was used to remove this fragment.
CONCLUSION:
In this case report we highlight a new modification of the 2-step technique that can be employed when the conventional 2 step technique does not work.
Association of Karnofsky Performance Status with liver transplant outcomes in hepatocellular carcinoma
Authors: Zhou Jie , Ye Danni , Zhang Siyao , Ding Jiawei , Zhang Tao , Chen Zheng , Xu Fangshen , Ren Shenli , Hu Zhenhua
Published: November 2022

Background
Functional performance as measured by the Karnofsky Performance Status (KPS) scale has been linked to the outcomes of liver transplant patients; however, the effect of KPS on the outcomes of the hepatocellular carcinoma (HCC) liver transplant population has not been fully elucidated. We aimed to investigate the association between pre-transplant KPS score and long-term outcomes in HCC patients listed for liver transplantation.
Methods
Adult HCC candidates listed on the Scientific Registry of Transplant Recipients (SRTR) database from January 1, 2011 to December 31, 2017 were grouped into KPS I (80–100%, n = 8,379), KPS II (50–70%, n = 8,091), and KPS III (10–40%, n = 1,256) based on percentage KPS score at listing. Survival was compared and multivariable analysis was performed to identify independent predictors.
Results
Patients with low KPS score had a higher risk of removal from the waiting list. The intent-to-treat survival and overall survival were significantly inferior for KPS III patients compared with KPS I and II (P < 0.001). Multivariable analysis demonstrated that KPS was an independent predictor of intent-to-treat survival and overall survival. KPS III patients had an increased cumulative rate of post-transplant tumor recurrence in the univariable analysis (P = 0.037), but this was not significant in the competing regression analysis.
Conclusions
Low pre-transplant KPS score is associated with inferior long-term survival in liver transplant HCC patients, but is not significantly associated with post-transplant tumor recurrence.
Combination Immunotherapy of Glioblastoma with Dendritic Cell Cancer Vaccines, Anti-PD-1 and Poly I:C: A Case Report
Authors: He You-Wen , Zhu Ping , Sun Sheng-Nan , Ding Jin , Zheng Zhao-Hui , Wei Ding , Jiang Jun , Miao Jin-Lin , Li San-Zhong , Fei Zhou , Zhang Kui , Wang Bin , Zhang Kun , Pu Su , Wang Qian-Ting , Zhang Xin-Yue , Wen Gao-Liu , Li Shi-You , Bian Hui-Jie , Chen Zhi-Nan , Liu Jun
Published: November 2022

Glioblastoma (GBM) is a lethal cancer with limited therapeutic options. Dendritic cell (DC)-based cancer vaccines represent a promising approach for GBM treatment. Clinical studies suggest that other immunotherapeutic agents including anti-PD-1 and immune adjuvant poly I:C may be combined with DC vaccines to further enhance antitumor activity. Here we report a GBM case with combination immunotherapy consisting of DC vaccines, anti-PD-1 and poly I:C as well as a chemotherapeutic agent cyclophosphamide that were integrated with the standard chemoradiation therapy for > 5 years. The patient who received DC vaccines loaded with multiple forms of tumor antigens including mRNA-tumor associated antigens (TAAs), mRNA-neoantigens, and hypochlorous acid-oxidized tumor lysates. Furthermore, mRNA-TAAs were modified with a novel TriVac technology which fuses TAAs with a destabilization domain and inserts TAAs into a full-length LAMP-1 to enhance MHC class I and II antigen presentation, respectively. The treatment consisted of 42 DC cancer vaccine infusions, 26 anti-PD-1 antibody nivolumab administrations and 126 poly I:C injections for DC infusions. The patient also received 28 doses of cyclophosphamide for depletion of regulatory T cells. No immunotherapy related adverse events were observed during the treatment. Robust anti-tumor CD4+ and CD8+ T cell responses were detected. The patient remains free of disease progression as of July, 2022. Our results suggest that integrated combination immunotherapy is safe and feasible for long-term treatment. A large scale trial to validate these findings is warranted.
Protocol numbers: 201708152377, 20202014-F-1
Evaluation of a thrombin generation assay in dogs administered clopidogrel
Authors: Rank Kaitlyn , Lynch Alex , Ruterbories Laura , Li Ronald , Ueda Yu
Published: November 2022

Background:
The antiplatelet effect of clopidogrel can vary between patients. A modified thromboelastography (TEG) protocol (TEG-Platelet Mapping assay® [TEG-PM]) can be used for clopidogrel monitoring but is not widely available. Thrombin generation (TG) assays could offer a novel alternative. The main objective of this pilot study was to assess TG assay variables (lag time, peak, endogenous thrombin potential [ETP]) in dogs before and after 7 days of clopidogrel administration, and compare with TEG-PM variables (maximum amplitude [MA]-ADP and percentage (%) inhibition). Six healthy mix-breed dogs were enrolled in this pilot study. Blood samples for platelet count, TG assays, and TEG-PM were obtained at two time points, corresponding to baseline, and after 7 days of clopidogrel administration (mean 2.3 +/- 0.3 mg/kg PO q24 hours). Data were then compared with a Student’s t-test.
Results
There was no significant change in TG assay variables performed on platelet poor plasma after 7 days of clopidogrel administration: lag time (Day 1: 1.8 +/- 0.2 min, Day 7: 1.8 +/- 0.2 min, P = 0.42); Peak (Day 1: 76 +/- 7 nM, Day 7: 72 +/- 10 nM, P = 0.49); and ETP (Day 1: 399 +/- 27 nM*min, Day 7: 392 +/- 32 nM*min; P = 0.49). There were significant changes in TEG MA-ADP (Day 1: 19 +/- 8 mm, Day 7: 9 +/- 6 mm, P = 0.04) and % inhibition (Day 1: 58 +/- 27, Day 7: 99 +/- 0.3, P = 0.02) however over the course of the study.
Conclusions
Clopidogrel administration did not lead to changes in TG assay variables performed on platelet poor plasma samples, despite concomitant changes in TEG-PM variables consistent with platelet inhibition. Thrombin generation performed on platelet poor plasma does not appear to be a useful antiplatelet monitoring tool in dogs.
Integrated analysis of the microbiota-gut-brain axis in response to sleep deprivation in a diet-induced obesity mouse model
Authors: Oh Chang Myung , Lee Jibeom , Kang Jiseung , Kim Yumin , Lee Sunjae , Kim Tae
Published: November 2022

Sleep deprivation (SD) and obesity are common in modern societies. SD and obesity frequently coexist, but research on the combined consequences of SD and obesity has been limited. In this study, we investigated the gut microbiota and host responses to SD and high-fat diet (HFD)-induced obesity. In addition, we attempted to identify key mediators of the microbiota-gut-brain axis. C57BL/6J mice were divided into four groups based on whether they were sleep deprived and whether they were fed a standard chow diet (SCD) or HFD. We then performed fecal microbiome shotgun sequencing, gut transcriptome analysis using RNA sequencing, and brain mRNA expression analysis using the nanoString nCounter Mouse Neuroinflammation Panel. The gut microbiota was significantly altered by the HFD, whereas the gut transcriptome was primarily influenced by SD. Sleep and diet are both important in the inflammatory system of the brain. When SD and the HFD were combined, the inflammatory system of the brain was severely disrupted. In addition, inosine-5' phosphate may be the gut microbial metabolite that mediates microbiota-gut-brain interactions. To identify the major drivers of this interaction, we analyzed the multi-omics data. Integrative analysis revealed two driver factors that were mostly composed of the gut microbiota. We discovered that the gut microbiota may be the primary driver of microbiota-gut-brain interactions. These findings imply that healing gut dysbiosis may be a viable therapeutic target for enhancing sleep quality and curing obesity-related dysfunction.
Microsatellite polymorphism based genetic variation among the natural populations of two sympatric species of Drosophila: D. bipectinate and D. malerkotliana
Authors: Singh Gurvachan , Singh Arvind Kumar
Published: November 2022

Background
Drosophila bipectinata and D. malerkotliana are found to be distributed all along the Oriental-Australian continents and have common phylogenetic descent. The genetic divergence of these two species, alongside their distribution zone have been the matter of research and therefore, genetic markers like chromosome inversions and allozyme variants have been considered to establish the nature and extent of variation they have experienced since their speciation.
Methods and Results
This study for the first time includes microsatellite markers to observe the genetic variations among the seven natural populations of D. bipectinata and six populations of D. malerkotliana. Results pertaining to D. bipectinata indicate that the level of average heterozygosity increases from north to south. Similar analysis carried out with D. malerkotliana also showed an increase in the level of average heterozygosity from north to south. Distinct genetic differentiation has been observed between north and south populations of both the species that give an indication that north and south populations have undergone genetic structuring due to absence of gene flow between them and varying environmental conditions of the two geographical zones. Based on the frequencies of microsatellite variants of the two species, we have computed the level of variation between these two species also.
Conclusions
The analysis in this regard shows almost similar trend of genetic variation being experienced by these two species which could be a kind of parallel evolution occurring due to similar ecological niches occupied by them and similar impact of evolutionary forces to the populations studied.
Single cell profiling reveals a reduction of CD56dim NK-cells and other immune cells in patients with Meniere disease and high levels of cytokines
Authors: Flook Marisa , Escalera-Balsera Alba , Rybakowska Paulina , Frejo Lidia , Batuecas-Caletrio Angel , Amor-Dorado Juan Carlos , Soto-Varela Andres , Alarcón-Riquelme Marta , Lopez-Escamez Jose Antonio
Published: November 2022

Background
Meniere Disease (MD) is an inner ear syndrome, characterized by sensorineural hearing loss associated with episodes of vertigo, tinnitus, and aural fullness. The pathological mechanism leading to sporadic MD is still poorly understood, however an inflammatory response seems to be involved in some patients with MD.
Methods
We performed mass cytometry immunoprofiling on peripheral blood from MD patients and controls to decipher an immune signature associated with the syndrome.
Results
We have identified two clusters of individuals according to the single cell cytokine profile. These clusters presented differences in immune cell population abundance, including a reduction of CD56dim NK-cells, and changes in cytokine expression with a different response to bacterial and fungal antigens. Moreover, we observe a difference in the levels of IgE between these two clusters.
Conclusions
Our results support a systemic inflammatory response in some MD patients that show an allergic phenotype, which could benefit from personalized IL-4 blockers. Immunoprofiling of patients with MD may lead to a better understanding of endotypes of the disease.
Failure to integrate? Investigating multisensory acceleration perception on a cable-robot simulator
Authors: Kang Hyeokmook , Yang Jaesik , Boss Rainer , Bülthoff Heinrich H , Wallraven Christian
Published: November 2022

Current powertrains in vehicles offer a broad spectrum of driving modes that shape the driving experience. One crucial factor for determining the human factors aspects of this driving experience is the perception and evaluation of acceleration-a complex, multisensory process that integrates auditory, vestibular, and visual input. Two important questions that need to be answered in order to better characterize this percept include: How do individual sensory inputs influence acceleration perception? and How does acceleration perception change at different acceleration levels? To address these questions, here we used a unique setup based on a cable-robot simulator that allowed us to manipulate the different modalities at different levels of acceleration with real-world, in-car data for maximum realism. Specifically, we measured the just noticeable differences (JNDs) of acceleration perception in five different modality combinations with the same set of participants. Our results showed that auditory acceleration perception was less sensitive compared to other modality combinations. In addition, we found evidence for the validity of Weber’s law with JNDs increasing linearly with increasing acceleration level. Interestingly, the multisensory data showed little evidence for effective cue integration of auditory information in this setup. These findings lay the groundwork for a better understanding of how different modalities work together in acceleration perception.
The possible protective effects of quercetin and/ or resveratrol against acrolein–induced sister chromatid exchanges and DNA damage in male albino mice.
Authors: El-Alfy Nagla , Mahmoud Mahmoud , Elashry Sally
Published: November 2022

Quercetin and resveratrol, common plant polyphenols, are widely distributed in human daily food and can contribute in the protection against the genotoxic toxic effects of various food contaminants and environmental pollutants. The aim of this study is to investigate the protective role of quercetin (50 mg/ kg body weight) and/ or resveratrol (12.5 mg/ kg body weight) against the genotoxicity of acrolein (10 mg/ kg body weight) in male albino mice using sister chromatid exchanges (SCEs) analysis and comet assay. The SCE analysis revealed that acrolein treatment significantly increased the SCEs frequency in bone marrow cells of acrolein-treated group in comparison with that of the control group, whereas pre-treatment with quercetin and/ or resveratrol significantly reduced it. Comet assay showed a significant increase in the comet parameters (tail length, tail DNA% and olive tail moment) in liver cells of acrolein-treated group in comparison with the corresponding control. In quercetin and/ or resveratrol pre-treated groups, the comet parameters were reduced in liver cells, indicating the anti-genotoxicity of quercetin and resveratrol. Pre-treatment with quercetin alone showed the best anti-genotoxic effect against acrolein-toxicity. Therefore, quercetin and resveratrol should be included in the human diet to antagonize the dangerous effects of mutagens like acrolein.
Breeding biology of isolated captive Dalmatian Pelicans (Pelecanus crispus) at the Shanghai Zoo, China
Authors: Xu Zhengqiang , Zhou Ying , Chen Zhibing
Published: November 2022

The breeding biology of a captive, isolated population of Dalmatian Pelicans (Pelecanus crispus) at the Shanghai Zoo, China, was studied from 2007 to 2019. The breeding age of the Dalmatian Pelicans was estimated at three to four years old, and they started breeding in late October or early November. The clutch size varied between one and two eggs per nest, and the eggs were 83.2 ± 4.8 mm in length, 55.6 ± 2.9 mm in breadth and 136.1 ± 21.5 g in weight. The fertility fluctuated slightly, with an average rate of 38.7 ± 9.7%, but remained consistently low. The survival rate of chicks fluctuated substantially from 0–100%, with an average survival rate of 68.6 ± 27.6%. The averaged values of observed heterozygosity, expected heterozygosity and polymorphism information content were 0.468, 0.465 and 0.446, respectively. It indicated that the population had a low heterozygosity and genetic diversity. There was a significant change in the breeding index compared to that recorded 40 years ago, which indicates that inbreeding depression has occurred in this small, isolated, captive population of Dalmatian Pelicans.