bluuebunny/crossref_metadata_2025 huggingface dataset:
Forking in Time
Authors: Bowden Calum
Published: October 2019

This article focuses on the way blockchains construct time and the implications that has on governance, paying particular attention to the original Bitcoin network. Blockchains enforce succession through consensus, and for this reason, the philosopher Nick Land argues that “The Blockchain solves the problem of spacetime”. The article uses Land’s argument as a starting point for understanding the crucial role time plays in the governance of blockchain networks. It asks if the technology can, in fact, be understood to solve the problem of absolute succession, to investigate ways in which forking, both a byproduct of distributed consensus and the mechanism through which blockchains are upgraded, breaks the power concentrating around Land’s definite article Blockchain.
The Environment Is Not A System
Authors: Brain Tega
Published: October 2019

This paper considers some of the limitations and possibilities of computational models in the context of environmental inquiry, specifically exploring the modes of knowledge production that it mobilizes. Historic computational attempts to model, simulate and make predictions about environmental assemblages, both emerge from and reinforce a systems view on the world. The word eco-system itself stands as a reminder that the history of ecology is enmeshed with systems theory and presup-poses that species entanglements are operational or functional. More surreptitiously, a systematic view of the environment connotes it as bounded, knowable and made up of components operating in chains of cause and effect. This framing strongly invokes possibilities of manipulation and control and implicitly asks: what should an ecosystem be optimized for? This question is particularly relevant at a time of rapid climate change, mass extinction and, conveniently, an unprecedented surplus of computing.
Digital territory, digital flesh
Authors: Roxanne Tiara
Published: October 2019

Western Indigenous cultures have been colonized, dehumanized and silenced. As AI grows and learns from colonial pre-existing biases, it also reinforces the notion that Natives no longer are but were. And since machine learning requires the input of categorical data, from which AI develops knowledge and understanding, compartmentalization is a natural behavior AI undertakes. As AI classifies Indigenous communities into a marginalized and historicized digital data set, the asterisk, the code, we fall into a cultural trap of recolonization. This necessitates an interference. A non-violent break. A different kind of rupture. One which fractures colonization and codification and opens a space for colonial recovery and survival. If we have not yetcontemporized the colonized Western Indigenous experience, how can we utilize tools of artificial intelligence such as the interface and digitality to create a space that de-codes colonial corporeality resulting in a sense of boundlessness, contemporization and survival?
Assemblages of desire
Authors: Uliasz Rebecca
Published: October 2019

This paper considers the operations of affective technology within contemporary technocapitalism through affect theory. It is argued that affective technologies enter into power arrangements with political and corporate interests, altering an acting bodies’ affect — in the Spinozan definition, the “capacity to affect and be affected” — within social and political life. Affective computation uses machine learning techniques to ‘capture’ and quantify affective intensities in data form, automating a normalizing logic of division and categorization that classifies bodies, emotions, and objects. Affective technologies invoke what Luciana Parisi called “automated decisionism,” where machine learning processes digitize incomputable states in order to impose a self-rationalizing logic structure that regulates a user-subject’s actions (Parisi, “Reprogramming Decisionism”). Affective technologies exert biopolitical control over users through quantified logics of division and devaluation. It is suggested thataffect might simultaneously operate as an analytic lens to speculate on whether collective affectivity and political agency might be reclaimed through using these technologies. The following concludes with an engagement with Deleuze and Guattari’s “assemblages of desire” to suggest that affective technologies might produce other micropolitical arrangements that increase user agency as social and political subjects.
Synthetic bodies and feeling generators
Authors: Carlo Michela De
Published: October 2019

The main purpose of this paper is to describe emerging forms of art and social practices that arise in the social media era, after the coming together of the self-awareness reflected in online environments and the conscious passivity of individuals to the algorithmic manipulation of desires. Accordingly, what follows is a brief introduction to these new forms of social structures and a description of the elements that shape the perfect projection of ourselves in our online experience, combined with samples of artworks investigating the forms and languages emerging in our social media life.
Qui sont les prestataires de l’aide sociale? Analyse des débats médiatiques entourant la réforme de l’aide sociale au Québec (2015-2016)
Authors: Maugère Amélie , Greissler Élisabeth
Published: October 2019

Au Québec, la réforme de la politique en matière d’aide sociale, annoncée par le gouvernement libéral en janvier 2015 et adoptée définitivement par le parlement le 10 novembre 2016, a été très controversée. Pour spécifier les modèles normatifs en compétition qui émergent de cette controverse, nous avons collecté l’ensemble des articles d’opinion (tribunes politiques et militantes, tribunes d’éditorialistes, courrier des lecteurs) parus dans trois journaux de masse québécois entre 2015 et 2016. En nous inspirant de l’analyse cognitive des politiques publiques (Muller, 2005), nous avons identifié les principales références normatives et cognitives qui y sont mobilisées. Cette analyse met en évidence que les pro-réforme et les anti-réforme utilisent peu les mêmes références; en particulier, les prestataires y sont rarement décrits avec les mêmes caractéristiques. Cependant, les anti-réforme ont rarement proposé dans leur argumentaire un modèle normatif profondément alternatif à celui développé par le gouvernement.
Judiciarisation de la pauvreté et non-accès aux services juridiques : quand Kafka rencontre Goliath
Authors: Bernheim Emmanuelle
Published: October 2019

La néolibéralisation du droit se traduit par le recours accru aux procédures juridiques associées au droit social pour sanctionner ou contrôler des personnes vivant en situation de pauvreté. C’est du moins ce que révèle l’étude des pratiques judiciaires québécoises en matière de logement, de santé mentale et de protection de la jeunesse. Parallèlement, depuis une vingtaine d’années, l’accessibilité des services juridiques n’a fait que diminuer, forçant un nombre de plus en plus important de personnes à faire face à la justice sans avocate ou avocat ou représentées par des avocates ou avocats sous-payés et débordés.
Le parcours de réussite d’une démarche en gestion du stress en milieu scolaire : au carrefour de la recherche, de l’éducation pour la santé et de la pédagogie
Authors: Guimond-Plourde Renée , Long Christine , Michaud Martine , Nadeau Joey
Published: October 2019

Ce texte met à contribution trois axes professionnels indissociables (recherche, soins infirmiers, direction d’école) qui ont permis l’élaboration et la réalisation d’un projet en gestion du stress qui célébrait son 25eanniversaire en 2013. Des résultats de recherches qualitatives servent comme balises orientant cette expérience de terrain ralliant la pédagogie et le bien-être en milieu scolaire. L’enjeu est de faire de l’école un environnement favorable à la santé et à la réussite de tous par la promotion d’une gestion saine du stress au quotidien. Cette démarche de partenariat parents/élèves/personnel scolaire sous-tend la nécessité de travailler en complémentarité pour permettre aux élèves/enfants d’acquérir les compétences essentielles tant pour la santé et le bien-être que pour la réussite scolaire. LeProjet en gestion du stress chez l’enfant de l’école Notre-Dame d’Edmundstonet leProgramme de formation du formateur en gestion du stressconfirment la fécondité de partenariats novateurs en éducation pour la santé qui soutiennent concrètement le lien « théorie/pratique » et la pertinence du pilotage institutionnel qui en assure la légitimité et la crédibilité.
Phänomenologie oder Kritizismus? Zur Auseinandersetzung zwischen Eugen Fink und Rudolf Zocher
Authors: Krijnen Christian
Published: October 2019

Auf Philosophen, die für Transzendentalphilosophie aufgelegt sind, hat die Diskussion zwischen Kritizismus, d. h. Neukantianismus, und Phänomenologie immer eine gewisse Faszination ausgeübt. Allerdings wurde diese Diskussion durch die verheerenden Ereignisse 1933-1945 jäh abgebrochen, ohne daß sie sich in der gebotenen Form hätte entfalten können. Die Faszination ist verständlich. Immerhin haben der Kritizismus des Marburger Neukantianismus (Cohen, Natorp, Cassirer et al.) und des südwestdeutschen Neukantianismus (Windelband, Rickert, Lask, Bauch u. a.) wie die von Husserl inaugurierte phänomenologische Bewegung versucht, die Exklusivität der Philosophie und der Erkenntnistheorie als prima philosophia subjekttheoretisch zu begreifen. Für beide Philosopheme gilt, daß die Subjektivität Objektivität (Gegenständlichkeit) begründet, das Transzendentale dem Empirischen logisch vorhergeht. Da es in puncto Objektivitätsbegründung jedoch ganz gravierende methodische und infolgedessen auch thematische Unterschiede zwischen Kritizismus und Phänomenologie gibt, stehen beide zugleich in einem fundamentalphilosophischen Konkurrenzverhältnis.
La idealidad del tiempo, Gödel y la relatividad
Authors: Castrejón Gilberto
Published: October 2019

En la KrV Kant plantea la idealidad del tiempo en términos de que no es algo que subsista por sí mismo. En este sentido, Gödel vio una reivindicación de Kant al encontrar algunas soluciones de las ecuaciones de campo de la relatividad. Pretendo llevar a cabo una actualización, a partir de la KrV, de la concepción kantiana del tiempo en Gödel, frente a críticas que consideran que éste sólo atendió a las “A-series del tiempo”: donde los eventos se ordenan en pasado, presente y futuro. La conclusión es que Kant sigue vigente, bajo ciertas condiciones, en la relatividad.
Una defensa de la actualidad de la Crítica de la razón pura
Authors: Lanchas Sánchez Alejandro
Published: October 2019

Nuestro ensayo consiste en una defensa de la actualidad de la KrV. Para ello propondremos aquí una lectura de un texto de la misma, Las anticipaciones de la percepción, donde se demuestra el principio trascendental (matemático) que fundamenta la posibilidad del conocimiento real del objeto de la sensación como contenido en una percepción, en la medida en que este posee una magnitud intensiva, un grado. Con ello apuntaremos a una defensa de la obra frente a las críticas contemporáneas que, tanto desde la ciencia como desde la propia filosofía, denuncian su pretendida inactualidad.
Sentido y límites de la filosofía transcendental en el proyecto kantiano
Authors: Turró Salvi
Published: October 2019

Partiendo de la (aparente) paradoja expresada en KrV A801/B829, se intentará esclarecer la comprensión kantiana de la filosofía transcendental frente a las otras partes del sistema. A tal efecto, se situará el proyecto global de la KrV ?tal como se especifica en el Canon de 1781? a la luz del concepto mundano de filosofía como teleologia rationis humanae y de su inserción en el horizonte histórico de la Bestimmung des Menschen de J.J. Spalding. Con ello se ganará una comprensión del proyecto crítico alejada tanto de las lecturas epistemológicas como de las metafísico-fenomenológicas.
“The Epistemological Interpretation of Transcendental Idealism and Its Unavoidable Slide into Compatibilism”
Authors: Dal Monte Daniel
Published: October 2019

This paper consists in two major parts. In the first part, I explain and defend Kant’s explicit rejection of compatibilist theories of freedom in the Critique of Practical Reason. I do this by a careful analysis of some contemporary compatibilist theories. In the second major part, I explain how the epistemological interpretation of Kant’s transcendental idealism inevitably degenerates into a compatibilist version of freedom. The upshot will be that epistemological interpretations of transcendental idealism are not viable because of their connection with compatibilism, which Kant rejected.
La refutación kantiana del idealismo y el realismo ingenuo reconsiderado
Authors: Amado Manuel
Published: October 2019

En su célebre “Refutación del Idealismo”, Kant ofrece un argumento que pretende socavar al “idealismo problemático”, según el cual la existencia de “objetos en el espacio por fuera de nosotros es dudosa e indemostrable”. Los objetivos de este texto son: primero, evaluar la refutación kantiana del idealismo; segundo, mostrar que la conclusión de la refutación puede ser entendida de al menos dos maneras, una débil y una fuerte. Y, finalmente, sugerir cómo tanto la versión fuerte como la débil son compatibles con el idealismo trascendental de Kant, si éste se compromete con una versión del realismo ingenuo.
Die konzeptualistische und die nicht-konzeptualistische Interpretation der Kooperationsthese
Authors: Fazio Sophia Maddalena
Published: October 2019

In diesem Beitrag wird anhand der sogenannten Kooperationsthese den kognitiven Dualismus Kants untersucht. Die konzeptualistische und die nicht-konzeptualistische Interpretation der Wechselwirkung der zwei Grundvermögen der Erkenntnis werden gegenübergestellt und ihre Kohärenz zu Kants transzentalphilosophischem Erkenntnismodelle wird hinterfragt. Ausgehend von Kants Bestimmung des Begriffes als repraesentatio generalis mit einem Inhalt und einem Umfang wird schließlich ein dritte Deutung des von Kant vertretenen kognitiven Dualismus vorgestellt.
El espacio en cuanto forma de los fenómenos y la tesis de la receptividad: mutua implicación
Authors: Contreras Gallegos Diana Gloria
Published: October 2019

Mi objetivo es hacer notar que existe un nexo de mutua implicación entre dos tesis kantianas: la tesis de la receptividad (nuestro conocimiento depende de que seamos afectados por los objetos) y la tesis del espacio en cuanto forma de los fenómenos. Un tratamiento completo de la tesis de la receptividad implica el idealismo trascendental de Kant en torno al espacio. Desde mi lectura, ello en absoluto afecta al realismo empírico kantiano. Para mostrar lo anterior, exploro aquí la segunda consecuencia ("b) a la que Kant arriba tras haber presentado sus argumentos en favor de la naturaleza a priori e intuitiva del espacio en la Estética Trascendental. 
Palabras clave:  espacio, forma de la intuición, receptividad, idealismo trascendental, realismo empírico
 
Abstract:
My purpose in this paper is to point out that there is a mutual implication between two Kantian thesis: the Receptivity Thesis (our knowledge depends on being affected by objects) and the thesis of the space at a form of the phenomena; so that, a full treatment of the receptivity thesis implies Kant's transcendental idealism of space. On my reading this doesn't compromise Kant's empirical realism. In order to show this I explore here the second consequence ("b") that Kant arrives after he shows his arguments in favour of the space in the Transcendental Aesthetics.
 
Keywords: space, form of intuition, receptivity, transcendental idealism, empirical realism
La deducción metafísica de las ideas a partir de las formas del silogismo
Authors: Caimi Mario Pedro Miguel
Published: October 2019

Kant sostiene, en la Crítica de la razón pura y en otros textos, que las ideas de la razón se originan en las formas del silogismo. Llamamos deducción metafísica de las ideas a esta investigación del origen de ellas en las formas del prosilogismo. Pero si bien Kant sostiene que esa actividad lógica  es el origen de las ideas, no muestra en detalle cómo se efectúa esa deducción metafísica de las ideas. En el presente trabajo se procura efectuar esa deducción
Estructura argumentativa, unidad temática y coherencia doctrinal en los Progresos de la metafísica de Immanuel Kant
Authors: Thisted Marcos Adrián
Published: October 2019

A pesar de la importancia que la Kantforschung concede a los Progresos de la metafísica, los principales estudios dedicados a esta obra inconclusa y póstuma del filósofo crítico coinciden en considerarla como carente de una nítida unidad temática, afectada por severas anomalías en su estructura argumentativa y con diversas incoherencias desde el punto de vista doctrinal. A partir de una revisión crítica de la edición de los textos efectuada por Friedrich T. Rink, nuestra contribución se propone indicar cuál sería la unidad temática de esta obra, identificar sus pilares argumentativos y, por último, establecer su coherencia doctrinal.
Una interpretación de la Stufenleiter de A 320/B 376. Contribución a la determinación precisa del carácter de la distinción entre intuiciones y conceptos.
Authors: Placencia Luis , Fuentes Javier
Published: October 2019

Uno de los fundamentos de la filosofía teórica de Kant consiste en las distinciones que hay entre las diversas representaciones, tales como las intuiciones y los conceptos. En efecto, son muchas las tesis kantianas que, al menos a primera vista, sólo pueden ser comprendidas a cabalidad bajo el supuesto de que se haya captado de manera adecuada cuál es la naturaleza de estas distintas representaciones. Lo anterior parece ser, por ejemplo, lo que ocurre con la conocida idea kantiana según la cual, para que haya conocimiento, deben concurrir intuiciones y conceptos.
Los Aforismos sobre religión y deísmo de J. G. Fichte. Presentación, debates abiertos y traducción.
Authors: Solé Jimena
Published: October 2019

Este artículo ofrece una presentación general y la traducción al español de uno de los documentos fundamentales para acceder al pensamiento de juventud de J G. Fichte. El texto, publicado póstumo bajo el título Aforismos sobre religión y deísmo, fue redactado por Fichte en 1790, luego de su estudio de la Crítica de la razón pura de Kant, pero antes del encuentro con la Crítica de la razón práctica, que motivó en él una profunda revolución interior. En la presentación general al texto, se abordan los debates que este fragmento ha motivado entre los especialistas, tanto respecto de las fuentes filosóficas del escrito —que refiere a la cuestión del supuesto spinozismo del joven Fichte—, como acerca del modo en que el texto debe ser interpretado.
Gualtiero Lorini y Robert B. Louden (eds.): Knowledge, Morals an Practice in Kant´s Anthropology, New York, Palgrave Macmillan, 2018
Authors: Lerussi Natalia Andrea
Published: October 2019

El trabajo reseña el libro editado en 2018 por Gualtiero Lorini y Robert Louden titulado "Knowledge, Morals and Practice in Kant´s Anthropology" (Palgrave/Macmillan) que compila artículos que exploran la antropología de Immanuel Kant, atienden a sus fuentes, a su vínculo con la filosofía trascendental y a sus aspectos sistemáticos.
Paula Órdenes y Anna Pickhan (eds.): Teleologische Reflexion in Kants Philosophie, Weisbaden, Springer, 2019
Authors: Reyna Fortes Rafael
Published: October 2019

Reseña del libro: 
Órdenes, P. y Pickhan, A., “Teleologische Reflexion in Kants Philosophie”. Springer, Wiesbaden, pp. 310. ISBN 978-3-658-23693-9
Eventos y normas
Authors: De Estudios Kantianos Revista
Published: October 2019

Eventos y normas
STUDI FENOMENOLOGI: MEKANISME KOPING PEREMPUAN YANG BELUM MEMPUNYAI KETURUNAN DITINJAU DARI ASPEK BUDAYA MINANGKABAU
Authors: Rahmaniza Rahmaniza , Riasmini Ni Made , Netrida Netrida
Published: October 2019

Phenomenology Study: Coping Mechanism of Women No Heredity Viewed by Minangkabau Culture. The Minangkabau tribe adheres to the matrilineal kinship system. Based on this system, when a woman suffers infertility, so it means the family has not the next generation, and the line of descent will cut off. This condition makes the women need to have a coping mechanism to avoid psychology problems, including depression, anxiety, stress, neglected, discrimination, under pressure to divorce, and perceive abused. The study aimed to explore the coping mechanism of infertility women in the context of Minangkabau culture. This phenomenology study applied an in-depth interview, which involved ten women who were selected through a snowball sampling technique. Collaizi’s analysis method resulted in six themes. Those themes are through psychological and social change, obtain a response from others, the views of Minangkabau culture, adaptive coping used by women no heredity, the families were main source support, community social support. The findings strengthen the justification to involve psycho-social aspects in the infertility treatment.Keywords: Coping mechanism, infertile women, Minangkabau culture Abstrak Suku Minangkabau menganut sistem kekerabatan matrilineal. Berdasarkan sistem ini, ketika seorang wanita menderita kemandulan, itu berarti keluarga tidak memiliki generasi berikutnya, dan garis keturunan akan terputus. Kondisi ini membuat perempuan perlu memiliki mekanisme koping untuk menghindari masalah psikologi, termasuk depresi, kecemasan, stres, diabaikan, diskriminasi, di bawah tekanan untuk bercerai, dan juga merasa dilecehkan. Penelitian ini bertujuan untuk mengeksplorasi mekanisme koping wanita infertilitas dalam konteks budaya Minangkabau. Studi fenomenologi ini menerapkan wawancara mendalam yang melibatkan sepuluh wanita yang dipilih melalui teknik pengambilan sampel bola salju. Melalui metode analisis dari Collaizi, menghasilkan enam tema. Tema-tema tersebut termasuk Mengalami perubahan psikologis dan perubahan sosial, mendapat  respon dari orang sekitarnya, pandangan budaya Minangkabau, koping adaptif yang digunakan oleh perempuan belum mempunyai keturunan, keluarga menjadi sumber dukungan utama, dukungan sosial dari masyarakat. Temuan ini memperkuat pembenaran untuk melibatkan aspek psiko-sosial dalam pengobatan infertilitas. Kata kunci: Budaya Mingkabau, mekanisme koping, perempuan infertile
Trajectories of Teachers’ Perceived Curriculum Coherence in the Context of Finnish Core Curriculum Reform
Authors: Sullanmaa Jenni , Pyhältö Kirsi , Soini Tiina , Pietarinen Janne
Published: October 2019

Teachers play a key role in transforming the national curriculum reform into classroom practice. This study explored individual variation in Finnish teachers’ (N = 901) perceptions of curriculum coherence during a one-year follow-up during the early stages of its implementation
in schools. Latent profile analysis revealed five distinctive profiles. The development of perceived curriculum coherence over the two measurements and the perceived school-level impact of the reform differed between the profiles. The results imply that teachers may need various kinds of support
to arrive at a coherent understanding of the curriculum over the process of its development and implementation.
Global marine biodiversity in the context of achieving the Aichi Targets: ways forward and addressing data gaps
Authors: Saeedi Hanieh , Reimer James Davis , Brandt Miriam I. , Dumais Philippe-Olivier , Jażdżewska Anna Maria , Jeffery Nicholas W. , Thielen Peter M. , Costello Mark John
Published: October 2019

In 2010, the Conference of the Parties of the Convention on Biological Diversity agreed on the Strategic Plan for Biodiversity 2011–2020 in Aichi Prefecture, Japan. As this plan approaches its end, we discussed whether marine biodiversity and prediction studies were nearing the Aichi Targets during the 4th World Conference on Marine Biodiversity held in Montreal, Canada in June 2018. This article summarises the outcome of a five-day group discussion on how global marine biodiversity studies should be focused further to better understand the patterns of biodiversity. We discussed and reviewed seven fundamental biodiversity priorities related to nine Aichi Targets focusing on global biodiversity discovery and predictions to improve and enhance biodiversity data standards (quantity and quality), tools and techniques, spatial and temporal scale framing, and stewardship and dissemination. We discuss how identifying biodiversity knowledge gaps and promoting efforts have and will reduce such gaps, including via the use of new databases, tools and technology, and how these resources could be improved in the future. The group recognised significant progress toward Target 19 in relation to scientific knowledge, but negligible progress with regard to Targets 6 to 13 which aimed to safeguard and reduce human impacts on biodiversity.
Problem gamblers spend less money when loot boxes are removed from a game: a before and after study of Heroes of the Storm
Authors: Zendle David
Published: October 2019

Loot boxes are items in video games that may be paid for with real-world money, but which contain randomised contents. There is a reliable correlation between loot box spending and problem gambling severity: the more money gamers spend on loot boxes, the more severe their problem gambling tends to be. However, it is unclear whether this link represents a case in which loot box spending causes problem gambling; a case in which the gambling-like nature of loot boxes cause problem gamblers to spend more money; or whether it simply represents a case in which there is a general dysregulation in in-game spending amongst problem gamblers, nonspecific to loot boxes. The multiplayer video game Heroes of the Storm recently removed loot boxes. In order to better understand links between loot boxes and problem gambling, we conducted an analysis of players of Heroes of the Storm (n = 112) both before and after the removal of loot boxes. There were a complex pattern of results. In general, when loot boxes were removed from Heroes of the Storm, problem gamblers appeared to spend significantly less money in-game in contrast to other groups. These results suggest that the presence of loot boxes in a game may lead to problem gamblers spending more money in-game. It therefore seems possible that links between loot box spending and problem gambling are not due to a general dysregulation in in-game spending amongst problem gamblers, but rather are to do with specific features of loot boxes themselves.
CLUBE DE CIÊNCIAS: REVISÃO SISTEMÁTICA DE LITERATURA DAS PRODUÇÕES STRICTO SENSU DOS ÚLTIMOS QUINZE ANOS / SCIENCE CLUB: A SYSTEMATIC REVIEW OF STRICTO SENSU LITERATURE OVER THE LAST FIFTEEN YEARS
Authors: Gonçalves Tatiane Alves , Denardin Luciano
Published: October 2019

Neste trabalho discute-se os resultados de uma revisão sistemática de literatura sobre clube de ciências, conduzida de acordo com as etapas preconizadas por Khan, Kunz e Kleijnen (2003). A fonte de busca foi a Biblioteca Digital Brasileira de Teses e Dissertações, resultando em um corpus de pesquisa constituído por 17 produções. Como resultados que emergiram da análise das produções inventariadas destacam-se que a maioria dos participantes das pesquisas são estudantes dos anos finais do ensino fundamental.  A maioria das produções objetivavam avaliar se as ações realizadas nos clubes de ciências contribuíam para a alfabetização científica. Outros trabalhos visavam analisar atividades investigativas ou avaliar produtos educacionais aplicados nesses espaços. Concluiu-se que os clubes de ciências contribuem para o desenvolvimento de uma cultura científica escolar e suprem a falta de estrutura e de tempo curricular dos professores no que diz respeito ao desenvolvimento de atividades experimentais em aulas regulares.
A CONSTRUÇÃO E APLICAÇÃO DE PROJETOS TEMÁTICOS E AS SUAS CONTRIBUIÇÕES PARA UMA ALFABETIZAÇÃO CIENTÍFICA E TECNOLÓGICA / THE CONSTRUCTION AND APPLICATION OF THEMATIC PROJECTS AND THEIR CONTRIBUTIONS TO A SCIENTIFIC AND TECHNOLOGICAL LITERACY
Authors: Devegili Karlinne Lisandra , Lawall Ivani Teresinha
Published: October 2019

A proposta deste trabalho é relacionar os objetivos gerais indicados para Alfabetização Científica e Tecnológica e as competências trazidas pelos Parâmetros Curriculares Nacionais para o Ensino de Física, frente a uma sequência didática destinada aos alunos de Ensino Médio, denominada Projeto Temático. E com isso, identificar situações didáticas elaboradas por estudantes universitários com o intuito de proporcionar uma Alfabetização Científica e Tecnológica aos estudantes de Ensino Médio ao longo da aplicação de dois Projetos Temáticos em forma de minicurso.
O CÁLCULO E OS TRÊS MUNDOS DA MATEMÁTICA: UM ESTADO DO CONHECIMENTO / THE CALCULUS AND THE THREE WORLDS OF MATHEMATICS: A STATE OF KNOWLEDGE
Authors: Bueno Rafael Winicius da Silva , Viali Lori
Published: October 2019

O presente artigo apresenta uma pesquisa realizada com o objetivo de sistematizar e analisar a produção científica brasileira, em nível de pós-graduação stricto sensu, envolvendo o ensino e aprendizagem de conceitos relativos ao Cálculo, no contexto da teoria dos Três Mundos da Matemática. Para tanto, primeiramente foi selecionado o corpus de análise do estudo, sendo, então, realizada a leitura flutuante dos textos para a constituição das bibliografias anotada, sistematizada e categorizada. Analisando as informações encontradas, percebeu-se que ainda são poucas as pesquisas realizadas na perspectiva investigada e que as existentes se concentram no conceito de derivada e no ensino e aprendizagem voltado para cursos de Engenharia. Nesse sentido, a ausência de trabalhos abordando o conceito de Integral, no contexto de Cursos de Licenciatura em Matemática, sob a ótica da teoria dos Três Mundos da Matemática, aponta uma direção e um sentido que ainda podem explorados em futuras investigações.
Palladium‐Catalyzed Synthesis of Benzothiophenes via Cross‐Dehydrogenative Coupling of 4‐Arylthiocoumarins and Pyrones
Authors: Zhang Jin , Zhuang Yuyu , Ma Yangmin , Yang Xiufang , Szostak Michal
Published: October 2019

Benzothiophenes represent a pivotal class of sulfur heterocycles and their synthesis has attracted significant attention to generate bioactive scaffolds. Herein, we report a convergent, atom‐ and step‐economic method for the synthesis benzothiophenes by cross‐dehydrogenative coupling (CDC) of 4‐arylthiocoumarins in good to excellent yields. We further demonstrate cross‐dehydrogenative coupling of 4‐arylthio‐2‐pyrones to afford alternative substitution of benzothiophenes. The presence of a labile ester carbonyl moiety provides functional handle for further functionalization by coumarin deconstruction. Most crucially, the manuscript demonstrates that the use of readily accessible templated synthesis has a significant potential for the rapid assembly of sulfur heterocycles by dehydrogenative coupling mechanism.

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Flexible parametric model for survival data subject to dependent censoring
Authors: Deresa Negera Wakgari , Van Keilegom Ingrid
Published: October 2019

When modeling survival data, it is common to assume that the (log‐transformed) survival time (T) is conditionally independent of the (log‐transformed) censoring time (C) given a set of covariates. There are numerous situations in which this assumption is not realistic, and a number of correction procedures have been developed for different models. However, in most cases, either some prior knowledge about the association betweenTandCis required, or some auxiliary information or data is/are supposed to be available. When this is not the case, the application of many existing methods turns out to be limited. The goal of this paper is to overcome this problem by developing a flexible parametric model, that is a type of transformed linear model. We show that the association betweenTandCis identifiable in this model. The performance of the proposed method is investigated both in an asymptotic way and through finite sample simulations. We also develop a formal goodness‐of‐fit test approach to assess the quality of the fitted model. Finally, the approach is applied to data coming from a study on liver transplants.
Comprehensive quantification of purine and pyrimidine metabolism in Alzheimer's disease postmortem cerebrospinal fluid by LC–MS/MS with metal‐free column
Authors: Muguruma Yoshio , Tsutsui Haruhito , Akatsu Hiroyasu , Inoue Koichi
Published: October 2019

The metabolome presence of nucleobases, nucleosides, nucleotides and related phosphorylated metabolites has been examined for Alzheimer's disease (AD). Although reversed‐phase liquid chromatography tandem mass spectrometry (LC–MS/MS) has been used for the determination of these analytes, they were limited in chromatographic signal intensity and reproducibility owing to significant peak tailing caused by complexing with metallic cations and phosphate groups. In this work, we applied LC–MS/MS analysis with a metal‐free column for comprehensive quantification of 40 analytes regarding to purine and pyrimidine metabolism in postmortem cerebrospinal fluid (pCSF) from AD patients. For the analytical column, an InertSustain AQ‐C18 metal‐free PEEK column was used. MS detection was by electrospray positive ionization. The metal‐free column allowed for sharp peak detection of highly polar metabolites within a running time of 17 min. In validation, the limits of detection (LOD), the limit of quantitation (LOQ) and recovery value using a pooled pCSF sample are 1–500  nM, 0.5–250 nM and a range of 53.1–144.0% (RSD ranged from 0.4 to 19.6%). The developed LC–MS/MS method utilizing a metal‐free column provides an accurate quantification of some metabolites regarding purine and pyrimidine metabolism in pCSF samples obtained from AD patients.
Differentiating Diffusivity in Different Channels of ZSM‐5 Zeolite by Pulsed Field Gradient (PFG) NMR
Authors: Zeng Shu , Xu Shutao , Gao Shushu , Gao Mingbin , Zhang Wenna , Wei Yingxu , Liu Zhongmin
Published: October 2019

Differentiating the diffusivity in straight channel and sinusoidal channel of ZSM‐5 zeolite is a prerequisite for catalyst optimization for the required product distribution with specific orientation. Herein, the intracrystalline diffusivities of n‐butane and iso‐butane in power ZSM‐5 zeolite were investigated by pulse field gradient (PFG) NMR, respectively. Different diffusion behaviors of the selected isomers were revealed. The effective self‐diffusion coefficient of n‐butane is about three orders of magnitude higher than that of iso‐butane. For the selected isomers, the opposite loading‐dependence were presented in self‐diffusion coefficients. Moreover, an equation containing diffusion tensors in different directions in orthogonal coordinate was successfully applied to fit the diffusion coefficients of n‐butane in straight and sinusoidal channel of ZSM‐5, respectively. The diffusivity of n‐butane in straight channel is nearly one order of magnitude faster than that in sinusoidal channel, predicting its dominant diffusion path.
Mixed‐phenotype acute leukemia: A cohort and consensus research strategy from the Children’s Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Authors: Orgel Etan , Alexander Thomas B. , Wood Brent L. , Kahwash Samir B. , Devidas Meenakshi , Dai Yunfeng , Alonzo Todd A. , Mullighan Charles G. , Inaba Hiroto , Hunger Stephen P. , Raetz Elizabeth A. , Gamis Alan S. , Rabin Karen R. , Carroll Andrew J. , Heerema Nyla A. , Berman Jason N. , Woods William G. , Loh Mignon L. , Zweidler‐McKay Patrick A. , Horan John T. ,   for the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Published: October 2019

Background

Optimal chemotherapy for treating mixed‐phenotype acute leukemia (MPAL) and the role of hematopoietic stem cell transplantation (HSCT) remain uncertain. Major limitations in interpreting available data are MPAL's rarity and the use of definitions other than the currently widely accepted criteria: the World Health Organization 2016 (WHO2016) classification.

Methods

To assess the relative efficacy of chemotherapy types for treating pediatric MPAL, the Children's Oncology Group (COG) Acute Leukemia of Ambiguous Lineage Task Force assembled a retrospective cohort of centrally reviewed WHO2016 MPAL cases selected from banking studies for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Patients were not treated in COG trials; treatment and outcome data were captured separately. The findings were then integrated with the available, mixed literature to develop a prospective trial in pediatric MPAL.

Results

The central review confirmed that 54 of 70 cases fulfilled WHO2016 criteria for MPAL. ALL induction regimens achieved remission in 72% of the cases (28 of 39), whereas AML regimens achieved remission in 69% (9 of 13). The 5‐year event‐free survival (EFS) and overall survival (OS) rates for the entire cohort were 72% ± 8% and 77% ± 7%, respectively. EFS and OS were 75% ± 13% and 84% ± 11%, respectively, for those receiving ALL chemotherapy alone without HSCT (n = 21).

Conclusions

The results of the COG MPAL cohort and a literature review suggest that ALL chemotherapy without HSCT may be the preferred initial therapy. A prospective trial within the COG is proposed to investigate this approach; AML chemotherapy and/or HSCT will be reserved for those with treatment failure as assessed by minimal residual disease. Embedded biology studies will provide further insight into MPAL genomics.
CARLo‐5 as an oncogenic gene in endometrial carcinoma
Authors: Zhao Xiwa , Zhang Cong , Wei Xurui , Shi Li , Dai Suli , Jia Jingde , Wei Sisi , Wang Yaojie , Wang Yanxiu , Cheng Jianxin , Zhao Lianmei
Published: October 2019

The long noncoding RNA CARLo‐5 is dysregulated in multiple types of human cancers. High CARLo‐5 is a promising predictive factor for various cancers, including endometrial carcinoma (EC). Our previous study showed that the expression level of CARLo‐5 was associated with advanced FIGO stage (The International Federation of Gynecology and Obstetrics), lymph node metastasis, and the poor survival of patients with EC. In the present study, we demonstrated that the downregulation of CARLo‐5 could affect the proliferation, cell cycle, migration, and invasion of EC cell lines HEC‐1B and KLE cells. The oncogenic activity of CARLo‐5 was also confirmed with in vivo data. Mechanistically, CARLo‐5 could affect the expression of CDK/CDKN1A and MMP2/9, which have been reported to be regulated by CARLo‐5 and associated with cell cycle and motility. In conclusion, this study is the first to discover the biological function and mechanism of CARLo‐5 in regulating the biological characteristics of EC cells. Targeting CARLo‐5 and its pathway might provide new biomarkers or potential therapies target for patients with EC. Environ. Mol. Mutagen. 61:256–265, 2020. © 2019 Wiley Periodicals, Inc.
Approaches for the evaluation of favorable shale gas areas and applications: Implications for China's exploration strategy
Authors: Li Zhen , Zhang Jinchuan , Tang Xuan , Gao Yu , Huo Zhipeng , Li Pei , Liu Junlan , Gong Dajian
Published: October 2019

To explore practical approaches for the evaluation of favorable shale gas areas, a structural decomposition analysis with respect to the index system, evaluation criteria, weight determination, and evaluation methods was carried out. Five types of indexes were determined from 25 subindexes that formed the index system, and improved whitenization weight functions are proposed to establish evaluation criteria. The index weights calculated using entropy weight and Euclidean distance methods are consistent, whereas the weights determined by gray relational analysis are significantly affected by the relative number of indexes and evaluation objects, selected mother factor, and resolution coefficient. The significant linear positive correlation between the relative approach degree values calculated using TOPSIS and the scores obtained using fuzzy comprehensive evaluation (FCE) is indicative of a consistent evaluation result, but it should be noted that extreme indicator values can have strong effects on the evaluation using the fuzzy similarity method. Finally, an exploration strategy for China's shale gas is suggested: Areas with weak reformation and relatively low maturity are expected to be favorable for marine shale production in South China, and continental and transitional shale‐bearing basins are promising for the prospecting multiple‐origin shale gas and coal measure gas, respectively.
Impacts of Holocene and modern sea‐level changes on estuarine mangroves from northeastern Brazil
Authors: Cohen Marcelo C.L. , Figueiredo Beatriz L. , Oliveira Nedra N. , Fontes Neuza A. , França Marlon Carlos , Pessenda Luiz C.R. , de Souza Adriana V. , Macario Kita , Giannini Paulo C.F. , Bendassolli José A. , Lima Paula
Published: October 2019

Projections of the impacts of modern Relative Sea Level (RSL) rise on estuarine mangroves should be supported by coastal topographic data and records of mangrove dynamics under past RSL change. This work identified inland and seaward mangrove migrations along the Jucuruçu River (Bahia, Northeastern Brazil), during the Holocene based on sedimentary features, palynological and geochemical (δ13C, δ15N, C/N) data integrated with digital elevation models. During the Middle Holocene, in response to RSL rise, the estuary saw mangrove forest establish up to ~37 km inland. RSL stood between ‐1.4 (+0.36/‐2.2 m) and +1 (2.19/0.2 m) around 7400 cal yr BP, and rose to a highest position of +3.25 (4.22/2.45 m) reached around 5350 cal yr BP. That marine incursion caused the inland replacement of freshwater vegetation by mangroves on tidal flats. Since then, the estuary experienced RSL fall, reducing inland tidal water salinity towards the Late Holocene, making that the mangroves were replaced by freshwater floodplain vegetation. Today, in the seaward part of the estuary near its mouth, mangroves occupy an area of ~10 km2 along tidal channels. Considering a RSL rise of 98 cm up to the end of the 21st century, at a rate significantly higher than that of Middle Holocene RSL rise (1.5 mm/yr) and fall (0.6 mm/yr), the current mangrove substrates are expected to drown and/or eroded near the coast, while new mangroves may establish inland, at topographically higher tidal flats in nowadays freshwater‐tidal zones. Mangrove area could expand over 13 km2 of coastal and flood plain. Following the same interaction between RSL/climate changes and Holocene mangrove dynamics, such upstream mangrove migration may be attenuated or intensified by changes in fluvial discharge. © 2019 John Wiley & Sons, Ltd.
Deglaciation history at the Alpine‐Mediterranean transition (Argentera‐Mercantour, SW Alps) from 10Be dating of moraines and glacially polished bedrock
Authors: Rolland Yann , Darnault Romain , Braucher Régis , Bourlès Didier , Petit Carole , Bouissou Stéphane ,   ASTER Team
Published: October 2019

Estimating the extent and age of the last glacial maxima as well as the chronology of glacial recessions in various environmental contexts is key to source‐to‐sink studies and paleoclimate reconstructions. The Argentera‐Mercantour massif is located at the transition between the Alps and the Mediterranean Sea, therefore, its deglaciation chronology can be compared to the sediment budget of the Var River basin. Based on 13 new cosmic‐ray exposure (CRE) beryllium‐10 (10Be) datings performed on moraines and polished crystalline bedrocks and 22 reassessed 10Be CRE ages from similar altitude nearby steep basement surfaces, and from a lake sediment core, we can constrain the deglaciation chronology of the Argentera‐Mercantour massif. These data allow for the first time to fully reconstruct the deglaciation history at the scale of the entire massif in agreement with a major glacier recession at c. 15 ka, at the onset of Bølling transition between the Oldest and Older Dryas. Main deglaciation of the upper slopes [2700–2800 m above sea level (a.s.l.)] occurred after the Last Glacial Maximum (LGM) at 20.8–18.6 ka, followed by the main deglaciation of the lower slopes (2300 m a.s.l.) at 15.3–14.2 ka. Finally, the flat polished surfaces above 2600 m a.s.l. and the zones confined within narrow lateral valleys were likely affected by progressive ice melting of remaining debris covered glaciers and moraine erosion following the Younger Dryas re‐advance stage between 12 and 8–9 ka. At lower elevations, the Vens Lake located at 2300 m a.s.l., allows evidence of the onset of lake sedimentation at c. 14 ka and a transition towards a vegetated environment that mainly occurred before 8 ka. Moraine final stabilization at 5 ka might reflect denudation acceleration during the Holocene humid phase. This contribution reveals a glacier–climate relationship more sensitive to warming phases in the southern Alps highlighted by a major decrease of glaciers after c. 15 ka. This major deglaciation is correlated with a 2.5‐fold decrease of sediment discharge of rivers into the Mediterranean Sea. © 2019 John Wiley & Sons, Ltd.
Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors
Authors: Bochner Filip , Mohan Vishnu , Zinger Assaf , Golani Ofra , Schroeder Avi , Sagi Irit , Neeman Michal
Published: October 2019

Pancreatic cancers, both adenocarcinomas and endocrine tumors are characterized by varying levels of aberrant angiogenesis and fibrotic microenvironment. The difficulty to deliver drugs and treat the disease has been attributed in part to the vascular architecture and tissue/ECM density. Here we present longitudinal three‐dimensional intravital imaging of vascular and tumor microenvironment remodeling in spontaneous transgenic tumors (RIP1‐Tag2 insulinomas) and orthotopically injected tumors (KPC adenocarcinomas). Analysis of the data acquired in insulinomas revealed major differences in tumor blood vessel branching, fraction volume, number of branch points segments, vessel straightness and length compared to the normal tissue. The aggressive adenocarcinoma presented widespread peritumoral vascular remodeling and heterogeneous vascular distribution. Longitudinal imaging was used to acquire sequential vascular remodeling data during tumor progression. This work demonstrates the potential for using a pancreatic intravital imaging window for direct visualization of the tumor heterogenic microenvironments during tumor progression.
Judge ends decades‐old lawsuit over jail services in Arizona county
Authors: Enos Gary
Published: October 2019

A federal class‐action lawsuit that dates back to the 1970s has finally been concluded, with a U.S. District Court judge's official closing of a case involving inadequate mental health care and other inhumane conditions for jail detainees in Maricopa County, Arizona.
Depression screening not warranted for certain heart patients
Authors: Canady Valerie A.
Published: October 2019

Although clinicians have engaged in the current practice of treating coronary heart disease survivors by screening them for depression, a new study published in JAMA Internal Medicine has found that patients screened for depression did not see any benefits. The study's findings call into question the current policy to screen these patients for depression.