bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood Purification in Patients with Sepsis Associated with Acute Kidney Injury: A Narrative Review
Authors: Kamei Jun , Kanamoto Masafumi , Igarashi Yutaka , Suzuki Kodai , Fujita Kensuke , Kuwana Tsukasa , Ogura Takayuki , Mochizuki Katsunori , Banshotani Yuki , Ishikura Hiroyasu , Nakamura Yoshihiko ,   J-STAD (Japan Sepsis Treatment and Diagnosis) Study Group
Published: October 2023

Sepsis leads to organ dysfunction. Acute kidney injury, a common type of organ dysfunction, is associated with a high mortality rate in patients with sepsis. Kidney replacement therapy can correct the metabolic, electrolyte, and fluid imbalances caused by acute kidney injury. While this therapy can improve outcomes, evidence of its beneficial effects is lacking. Herein, we review the indications for blood purification therapy, including kidney replacement therapy, and the current knowledge regarding acute kidney injury in terms of renal and non-renal indications. While renal indications have been well-documented, indications for blood purification therapy in sepsis (non-renal indications) remain controversial. Excessive inflammation is an important factor in the development of sepsis; blood purification therapy has been shown to reduce inflammatory mediators and improve hemodynamic instability. Given the pathophysiology of sepsis, blood purification therapy may decrease mortality rates in these patients. Further trials are needed in order to establish the effectiveness of blood purification therapy for sepsis.
Mid-Term Outcomes of a Pre-Cannulated Iliac Branched Device in the Treatment of Abdominal Aortoiliac Aneurysms: A Retrospective Analysis from a Single Center
Authors: Bonorden Constantin , Shoura Mohamed , Andic Mateja , Hahn Julia Kelley , Mustafi Migdat , Schlensak Christian , Lescan Mario
Published: October 2023

The aim was to assess the mid-term results of the E-iliac branched device. Baseline and follow-up data of this monocentric retrospective cohort study including all consecutive patients with aortoiliac aneurysms treated with iliac branched devices between 2016 and 2023 were extracted from the hospital records. Preoperative and follow-up CT scans were analyzed regarding endoleaks, migration, aneurysm sac remodeling, and device patency. Overall, 50 devices were implanted in 38 patients with a median age of 69 (IQR 62–78) years, and 1.6 bridging stent grafts per vessel were implanted through transfemoral (22/50; 44%) or upper extremity access (28/50; 56%). Primary technical success and assisted technical success were 97% (37/38) and 100% (38/38), respectively. No migration, no type I or III endoleaks, no stroke, colonic ischemia, aneurysm rupture, or conversion during the early and mid-term follow-ups (11 months, IQR 5–26) were observed. Aneurysm sac enlargement or shrinkage was observed in 0% (0/38) and 16% (6/38) patients, respectively. E-iliac-related re-interventions were seen only during the early follow-up: two thrombectomies with bare-metal stent relining after thrombosis of the iliac limb. Bridging stent graft and E-iliac patency during the mid-term follow-up were 100%. E-iliac showed encouraging mid-term results in the treatment of aortoiliac aneurysms with high technical success and a low re-intervention rate.
Obesity Characteristics Are Poor Predictors of Genetic Mutations Associated with Obesity
Authors: Al-Humadi Ahmed W. , Alabduljabbar Khaled , Alsaqaaby Moath S. , Talaee Hani , le Roux Carel W.
Published: October 2023

Background: The genetic contribution to obesity is substantial and may underpin the altered pathophysiology. One such pathway involves melanocortin signaling in the hypothalamus. Genetic variants can cause dysregulation in the central melanocortin pathway that can result in early onset of hyperphagia and obesity. Clinically identifying patients who are at risk of known genetic mutations is challenging. The main purpose of this study was to identify associations between the clinico-demographical characteristics and the presence of a genetic mutation associated with obesity. Methods: We tested samples from 238 adult patients with class III obesity between October 2021 to February 2023 using next-generation sequencing (NGS) (Illumina, NovaSeq 6000 Sequencing System). The results were classified as “no variant identified” or “variant identified”. Results: 107 patients (45%) had one or more gene mutation in the leptin–melanocortin pathway. All variants were heterozygous. The patients with a gene mutation had a BMI of 48.4 ± 0.8 kg/m2 (mean ± SEM), and those without a gene mutation had a BMI of 49.4 ± 0.7 kg/m2 (p = 0.4). The mean age of onset of obesity in patients with a gene mutation was 13.9 ± 1.3 years and for those without gene mutations was 11.5 ± 0.9 years (p = 0.1). The incidence of hyperphagia as a child was also not predictive (p = 0.4). Conclusions: Gene mutations associated with obesity in patients with a BMI > 40 kg/m2 are common. However, a patient’s BMI, age of onset of obesity, or age of onset of hyperphagia did not help to differentiate which patients may be more likely to have genetic mutations associated with obesity.
Exploring the Effect of Preoperative Stereopsis on Visual Outcomes in Hyperopic Presbyopes Treated with PresbyOND® Laser Blended Vision Micro-Monovision
Authors: Hernández-Lucena Julia , Alonso-Aliste Federico , Amián-Cordero Jonatan , Sánchez-González José-María
Published: October 2023

We investigated the effects of Laser Blended Vision (LBV) on binocular summation and stereopsis in the treatment of presbyopia and hyperopia. Using a unidirectional, retrospective longitudinal design, data from 318 patients who underwent the Zeiss PresbyOND® LBV surgical procedure at Tecnolaser Clinic Vision Ophthalmology Center in Seville, Spain, were analyzed. The findings indicate that stereopsis quality significantly influenced short-term post-operative visual outcomes in measures like Uncorrected Distance and Near Visual Acuity (UDVA and UNVA). However, the impact of stereopsis on visual outcomes appeared to diminish over time, becoming statistically insignificant at the 12-month post-operative mark. The study suggests that while stereopsis is a crucial factor in the short term, its influence on visual outcomes tends to wane in the long-term postoperative period. Future studies are essential to elucidate the enduring clinical ramifications of these observations.
Substance P and Neurokinin-1 Receptor System in Thyroid Cancer: Potential Targets for New Molecular Therapies
Authors: Isorna Inmaculada , González-Moles Miguel Ángel , Muñoz Miguel , Esteban Francisco
Published: October 2023

In recent years, numerous approaches have been developed to comprehend the molecular alterations underlying thyroid cancer (TC) oncogenesis and explore novel therapeutic strategies for TC. It is now well established that the neurokinin-1 receptor (NK-1R) is overexpressed in cancer cells and that NK-1R is essential for the viability of cancer cells. The binding of substance P (SP) to NK-1R in neoplastic cells plays a pivotal role in cancer progression by promoting neoplastic cell growth, protecting tumor cells from apoptosis, triggering invasion and metastasis through the enhanced migration of cancer cells, and stimulating endothelial cell proliferation for tumor angiogenesis. Remarkably, all types of human TC (papillary, follicular, medullary, anaplastic), as well as metastatic lesions, exhibit the overexpression of SP and NK-1R compared to the normal thyroid gland. TC cells synthesize and release SP, which exerts its multiple functions through autocrine, paracrine, intracrine, and neuroendocrine processes, including the regulation of tumor burden. Consequently, the secretion of SP from TC results in increased SP levels in plasma, which are significantly higher in TC patients compared to controls. Additionally, NK-1R antagonists have demonstrated a dose-dependent antitumor action. They impair cancer cell proliferation on one side and induce apoptosis of tumor cells on the other side. Furthermore, it has been demonstrated that NK-1R antagonists inhibit neoplastic cell migration, thereby impairing both invasiveness and metastatic abilities, as well as angiogenesis. Given the consistent overexpression of NK-1R in all types of TC, targeting this receptor represents a promising therapeutic approach for TC. Therefore, NK-1R antagonists, such as the drug aprepitant, may represent novel drugs for TC treatment.
The Effect of Adipose-Derived Mesenchymal Stem Cells on Peripheral Nerve Damage in a Rodent Model
Authors: Yalçın Mehmet Burak , Bora Ejder Saylav , Erdoğan Mümin Alper , Çakır Adem , Erbaş Oytun
Published: October 2023

Peripheral nerve damage is a significant clinical problem with limited therapeutic options. Adipose-derived mesenchymal stem cells (ADSCs) have emerged as a promising therapeutic approach due to their regenerative potential. However, the underlying mechanisms by which ADSCs promote peripheral nerve regeneration remain unclear. In this study, we investigated the role of syndecan-1 and heat shock protein 70 (HSP-70) in mediating the regenerative effects of ADSCs on peripheral nerves. ADSCs were characterized and isolated from the adipose tissue of rats. In vitro experiments were conducted to evaluate the ability of ADSCs to secrete syndecan-1 and HSP-70 in response to stress conditions. To evaluate the therapeutic potential of ADSCs, rats with sciatic nerve injuries were treated with ADSCs and assessed for functional recovery, nerve regeneration, and changes in syndecan-1 and HSP-70 levels. Regeneration was evaluated with Electromyography (EMG) histology. The results showed that ADSCs could secrete syndecan-1 and HSP-70 in response to stress conditions. Furthermore, ADSC treatment significantly improved functional recovery and nerve regeneration and increased syndecan-1 and HSP-70 levels in the injured nerve. On the other hand, ADSCs make improvements histologically through the influence of Nerve growth factor (NGF), Malondialdehyde (MDA), and EMG.
Coronary Artery Disease: A Key Issue in Type 2 Myocardial Infarction: Systematic Review and Recent Findings
Authors: Yao Hermann , Zeller Marianne , N’Guetta Roland , Cottin Yves , Putot Alain
Published: October 2023

Underlying coronary artery disease (CAD) is increasingly considered to be a key issue in the pathophysiology of type 2 myocardial infarction (T2MI). In T2MI, which is attributable to a mismatch between oxygen supply/demand, CAD is common and appears to be more severe than in type 1 myocardial infarction (T1MI). Little is known about the heterogeneous mechanisms that cause supply/demand imbalance and non-coronary triggers leading to myocardial ischemia or about how they are potentially modulated by the presence and severity of CAD. CAD seems to be underrecognized and undertreated in T2MI, even though previous studies have demonstrated both the short and long-term prognostic value of CAD in T2MI. In this literature review, we attempt to address the prevalence and severity of CAD, challenges in the discrimination between T2MI and T1MI in the presence of CAD, and the prognostic value of CAD among patients with T2MI.
Bronchiectasis-COPD Overlap Syndrome: Role of Peripheral Eosinophil Count and Inhaled Corticosteroid Treatment
Authors: Oscullo Grace , Gómez-Olivas Jose Daniel , Ingles Marina , Mompean Sergio , Martinez-Perez Rosalia , Suarez-Cuartin Guillermo , Rosa-Carrillo David la , Martinez-Garcia Miguel Angel
Published: October 2023

Both chronic obstructive pulmonary disease and bronchiectasis are highly prevalent diseases. In both cases, inhaled corticosteroids (ICs) are associated with a decrease in exacerbations in patients with a high peripheral blood eosinophil count (BEC), but it is still not known what occurs in bronchiectasis-COPD overlap syndrome (BCOS). The present study aimed to assess the effect of ICs on various outcomes in patients with BCOS, according to BEC values. We undertook a post-hoc analysis of a cohort of 201 GOLD II-IV COPD patients with a long-term follow-up (median 74 [IQR: 40–106] months). All participants underwent computerized tomography and 115 (57.2%) had confirmed BCOS. A standardized clinical protocol was followed and two sputum samples were collected at each medical visit (every 3–6 months), whenever possible. During follow-up, there were 68 deaths (59.1%), and the mean rate of exacerbations and hospitalizations per year was 1.42 (1.2) and 0.57 (0.83), respectively. A total of 44.3% of the patients presented at least one pneumonic episode per year. The mean value of eosinophils was 402 (112) eosinophils/µL, with 27 (23.5%), 63 (54.8%), and 25 patients (21.7%) presenting, respectively, less than 100, 101–300, and more than 300 eosinophils/µL. A total of 84 patients (73.1%) took ICs. The higher the BEC, the higher the annual rate of exacerbations and hospitalizations. Patients with less than 100 eosinophils/µL presented more infectious events (incident exacerbations, pneumonic episodes, and chronic bronchial infection via pathogenic bacteria). Only those patients with eosinophilia (>300 eosinophils/µL) treated with ICs decreased the number (1.77 (1.2) vs. 1.08 (0.6), p < 0.001) and the severity (0.67 (0.8) vs. 0.35 (0.5), p = 0.011) of exacerbations, without any changes in the other infectious outcomes or mortality. In conclusion, ICs treatment in patients with BCOS with increased BEC decreased the number and severity of incident exacerbations without any negative influence on other infectious outcomes (incidence of pneumonia or chronic bronchial infection).
PNI as a Potential Add-On Biomarker to Improve the IMDC Intermediate Prognostic Score
Authors: Bayoğlu İbrahim Vedat , Hüseynov Javid , Topal Alper , Sever Nadiye , Majidova Nargiz , Çelebi Abdussamet , Yaşar Alper , Arıkan Rukiye , Işık Selver , Hacıoğlu Muhammet Bekir , Ercelep Özlem , Sarı Murat , Erdoğan Bülent , Hacıbekiroğlu İlhan , Topaloğlu Sernaz , Köstek Osman , Çiçin İrfan
Published: October 2023

Introduction: This study aimed to assess the role of the adjusted PNI-IMDC risk scoring system in stratifying the intermediate group of metastatic RCC patients who received TKIS in the first-line setting. Methods: A total of 185 patients were included. The adjusted PNI and IMDC model was used to divide the intermediate group into two groups: intermediate PNI-high and intermediate PNI-low groups. The statistical data were analyzed using Kaplan–Meier and Cox regression analysis. Results: The results showed that the adjusted PNI-IMDC risk score, classic IMDC, and PNI had similar prognostic values. Adjusted PNI-IMDC risk score might be used for a more homogeneous differentiation of the classic intermediate group. On the other hand, multivariate analysis revealed that the presence of nephrectomy, adjusted favorable/intermediate (PNI-high) group, ECOG performance score, and presence of bone metastasis were independent predictors of OS. Conclusions: Pre-treatment PNI, as a valuable and potential add-on biomarker to the adjusted PNI-IMDC classification model, can be helpful for establishing an improved prognostic model for intermediate group mRCC patients treated with first-line TKISs. Further validation studies are needed to clarify these findings.
Renal Biopsy for Diagnosis in Kidney Disease: Indication, Technique, and Safety
Authors: Schnuelle Peter
Published: October 2023

Renal biopsies are the gold standard for diagnosis, staging, and prognosis of underlying parenchymal kidney disease. This article provides an overview of the current indications and highlights ways to reduce bleeding complications in order to achieve optimal diagnostic yield with minimal risk to the patient. Novel indications have emerged from the increasing use of new molecularly targeted oncologic therapies in recent years, which often induce immune-mediated renal disease. On the other hand, the detection of specific antibodies against target antigens on podocytes in the sera of patients with new-onset nephrotic syndrome has now relativized the indication for biopsy in membranous nephropathy. The use of semi-automatic spring-loaded biopsy devices and real-time ultrasound considerably declined the complication rate and is the current standard. Percutaneous renal biopsies are overall a safe procedure if contraindications are considered. A coagulation disorder needs to be excluded beforehand, and an elevated blood pressure must be reduced to the normotensive range with medications. A laparoscopic approach or a radiology interventional procedure through the internal jugular vein may be considered for obtaining a kidney tissue sample if there is an urgent indication and a bleeding tendency cannot be adequately corrected. Major bleeding after a percutaneous renal biopsy can usually be managed with selective arterial embolization of the injured renal vessel. The use of a 16-gauge needle is the most reasonable compromise between diagnostic benefit and risk of complication. In the routine diagnostic, the biopsy specimen is examined with light microscopy, immunohistochemistry, and electron microscopy. Combination with modern molecular pathology techniques will contribute to more precise insights into the development and progression of kidney disease, which will likely refine future treatments in nephrology.
Low-Dose Rivaroxaban to Prevent Recurrences of Venous Thromboembolism in Cancer: A Real-Life Experience with a Focus on Female Patients
Authors: Santini Paolo , Mosoni Carolina , D’Errico Alessandro , Porceddu Enrica , Lupascu Andrea , Valeriani Emanuele , Tondi Paolo , Pola Roberto , Porfidia Angelo
Published: October 2023

Background: The way in which to prevent recurrent venous thromboembolism (VTE) is an unmet clinical need in cancer patients. International guidelines only provide conditional recommendations and do not specify which anticoagulant and dose should be used. In the last 2 years, we have been using low-dose rivaroxaban to prevent VTE recurrences in cancer patients. The results of this real-life experience are presented in this study. Methods: All patients had cancer and had previously completed a cycle of at least six months of full-dose anticoagulation for the treatment of a VTE index event, before receiving a prescription of low-dose rivaroxaban (10 mg once daily) for secondary prevention of VTE. Effectiveness and safety of this therapeutic regimen were evaluated in terms of VTE recurrences, major bleedings (MB), and clinically relevant non-major bleedings (CRNMB). Results: The analysis included 106 cancer patients. Their median age was 60 years (IQR 50–69). Metastatic cancer was present in 87 patients (82.1%). Six patients (5.7%) had brain metastases. Over a median follow-up time of 333 days (IQR 156–484), the incidence of VTE recurrences was 3.8% (95%CI 1.0–9.4), with a recurrence rate of 4.0 per 100 person-years (95%CI 1.1–10.2). We observed no MB (0.0%) and three CRNMB (2.8%) (95%CI 0.6–8.1). Conclusions: Low-dose rivaroxaban is potentially effective and safe in cancer patients that require prevention of recurrent VTE. Large-scale studies are needed to confirm these findings.
Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches
Authors: Choi Jaewoo , Lee Eun Ji , Jang Woong Bi , Kwon Sang-Mo
Published: October 2023

Within the human body, the intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen and maintaining homeostasis. Bioprinting is an innovative technology with the potential to revolutionize this field by constructing complex multicellular structures. This technique offers the advantage of depositing individual cells, growth factors, and biochemical signals, thereby facilitating the growth of functional blood vessels. Despite the challenges in fabricating vascularized constructs, bioprinting has emerged as an advance in organ engineering. The continuous evolution of bioprinting technology and biomaterial knowledge provides an avenue to overcome the hurdles associated with vascularized tissue fabrication. This article provides an overview of the biofabrication process used to create vascular and vascularized constructs. It delves into the various techniques used in vascular engineering, including extrusion-, droplet-, and laser-based bioprinting methods. Integrating these techniques offers the prospect of crafting artificial blood vessels with remarkable precision and functionality. Therefore, the potential impact of bioprinting in vascular engineering is significant. With technological advances, it holds promise in revolutionizing organ transplantation, tissue engineering, and regenerative medicine. By mimicking the natural complexity of blood vessels, bioprinting brings us one step closer to engineering organs with functional vasculature, ushering in a new era of medical advancement.
The Use of Graphene Oxide in Orthodontics—A Systematic Review
Authors: Rygas Joanna , Matys Jacek , Wawrzyńska Magdalena , Szymonowicz Maria , Dobrzyński Maciej
Published: October 2023

Background: Graphene-based materials have great prospects for application in dentistry and medicine due to their unique properties and biocompatibility with tissues. The literature on the use of graphene oxide in orthodontic treatment was reviewed. Methods: This systematic review followed the PRISMA protocol and was conducted by searching the following databases: PubMed, Scopus, Web of Science, and Cochrane. The following search criteria were used to review the data on the topic under study: (Graphene oxide) AND (orthodontic) ALL FIELDS. For the Scopus database, results were narrowed to titles, authors, and keywords. A basic search structure was adopted for each database. Initially, a total of 74 articles were found in the considered databases. Twelve articles met the inclusion criteria and were included in the review. Results: Nine studies demonstrated the antibacterial properties of graphene oxide, which can reduce the demineralization of enamel during orthodontic treatment. Seven studies showed that it is biocompatible with oral tissues. Three studies presented that graphene oxide can reduce friction in the arch-bracket system. Two studies showed that it can improve the mechanical properties of orthodontic adhesives by reducing ARI (Adhesive Remnant Index). Three studies demonstrated that the use of graphene oxide in the appropriate concentration can also increase the SBS (shear bond strength) parameter. One research study showed that it can increase corrosion resistance. One research study suggested that it can be used to accelerate orthodontic tooth movement. Conclusion: The studies included in the systematic review showed that graphene oxide has numerous applications in orthodontic treatment due to its properties.
Acoustic Field Radiation Prediction and Verification of Underwater Vehicles under a Free Surface
Authors: Chen Yung-Wei , Pan Cheng-Cheng , Lin Yi-Hsien , Shih Chao-Feng , Shen Jian-Hong , Chang Chun-Ming
Published: October 2023

This study aimed to examine the acoustic field radiated by propellers and underwater vehicles. For the verification of sound radiation in underwater vehicles, numerical methods are widely used in addition to experiments and propeller blade frequencies for calculation and validation. Numerical convergence and accuracy are more important for near-field and far-field problems. This paper uses the boundary element method (BEM) to assess the convergence of the finite volume method (FVM). In this study, the FVM, including the Reynolds-averaged Navier–Stokes method and the Ffowcs Williams–Hawkings (FW-H) acoustic model, is used to investigate the influence of various geometric inflows on the hydrodynamic and noise performance of the propeller. Then, the sound radiation of the FVM is compared with the BEM at the far field to determine the number of meshed elements. Furthermore, spectral analysis is being conducted to examine the noise generated by the underwater vehicle and propeller. The objective is to investigate the influence of the free surface on propeller efficiency. After verifying the numerical simulation, the results indicate that a relationship can be established between water pressure and propeller thrust under specific conditions. This relationship can be used to estimate the magnitude of propeller thrust at different water depths. The simulated results of propeller thrust, torque coefficient, propulsion efficiency, and sound radiation in this study are consistent with experimental values. This demonstrates the accuracy and practicality of the findings of numerical procedures in engineering applications.
On the Digital Twin of The Ocean Cleanup Systems—Part I: Calibration of the Drag Coefficients of a Netted Screen in OrcaFlex Using CFD and Full-Scale Experiments
Authors: Gonzalez Jimenez Martin Alejandro , Rakotonirina Andriarimina Daniel , Sainte-Rose Bruno , Cox David James
Published: October 2023

The Ocean Cleanup introduces a Digital Twin (DT) describing the cleanup systems made of netting to extract marine litter from our oceans. It consists of two wings forming a “U-shape” and a retention zone. During operation, the system is towed and drag-driven with a span-to-length ratio of 0.6 ≤SR*≤ 0.8. The twine Reynolds number is Ret*∈[800:1600], making it experience various local drag coefficients. The DT was built with OrcaFlex (OF) aiming at: (i) avoiding over- or under-designing the system; (ii) supporting the scale-up of the system; and (iii) estimating the costs and/or the impact of our offshore operations. Therefore, we present an attempt to build an accurate DT using data from the Great Pacific Garbage Patch (GPGP). We developed a three-cycle validation: (i) initial guess applying Naumov’s semi-empirical drag coefficient to define the OF drag coefficients without the influence of the angles of attack θ of the wings; (ii) adjustment of the OF drag coefficients using AquaSim (AS) with its twine-by-twine drag correlation for various θ; (iii) re-adjustment of the OF drag coefficients from two-dimensional CFD simulations using Direct Numerical Simulation (DNS) for a twine-by-twine establishment of a drag correlation on a 1 m plane net, highlighting the shielding effects for θ<24°. Consequently, an initial underestimation of −3% in the combined towline tension, for a nominal span (SR*=0.6), was corrected to a slight overestimation of +7% compared to the GPGP data. For a wide span (SR*=0.8), the deviation remained between +1% and +15% throughout the validation process. For a narrow span (SR*∼ 0.02), mostly exhibiting low θ, the first cycle showed a +276% deviation, whereas at the end of the third cycle, it showed a +43% deviation.
Trichoderma hamatum and Its Benefits
Authors: Lodi Rathna Silviya , Peng Chune , Dong Xiaodan , Deng Peng , Peng Lizeng
Published: October 2023

Trichoderma hamatum (Bonord.) Bainier (T. hamatum) belongs to Hypocreaceae family, Trichoderma genus. Trichoderma spp. are prominently known for their biocontrol activities and plant growth promotion. Hence, T. hamatum also possess several beneficial activities, such as antimicrobial activity, antioxidant activity, insecticidal activity, herbicidal activity, and plant growth promotion; in addition, it holds several other beneficial properties, such as resistance to dichlorodiphenyltrichloroethane (DDT) and degradation of DDT by certain enzymes and production of certain polysaccharide-degrading enzymes. Hence, the current review discusses the beneficial properties of T. hamatum and describes the gaps that need to be further considered in future studies, such as T. hamatum’s potentiality against human pathogens and, in contrast, its role as an opportunistic human pathogen. Moreover, there is a need for substantial study on its antiviral and antioxidant activities.
Arbuscular Mycorrhizal Fungi Alter Arsenic Translocation Characteristics of Iris tectorum Maxim.
Authors: Xing Shuping , Zhang Kangxu , Hao Zhipeng , Zhang Xin , Chen Baodong
Published: October 2023

Arsenic (As) pollution in wetlands, mainly as As(III) and As(V), has threatened wetland plant growth. It has been well documented that arbuscular mycorrhizal (AM) fungi can alleviate As stress in terrestrial plants. However, whether AM fungi can protect natural wetland plants from As stress remains largely unknown. Therefore, three hydroponic experiments were conducted in which Iris tectorum Maxim. (I. tectorum) plants were exposed to As(III) or As(V) stresses, to investigate the effects of mycorrhizal inoculation on As uptake, efflux, and accumulation. The results suggested that short-term kinetics of As influx in I. tectorum followed the Michaelis–Menten function. Mycorrhizal inoculation decreased the maximum uptake rate (Vmax) and Michaelis constant (Km) of plants for As(III) influx, while yielding no significant difference in As(V) influx. Generally, mycorrhizal plants released more As into environments after 72 h efflux, especially under As(V) exposure. Moreover, mycorrhizal plants exhibited potential higher As accumulation capacity, probably due to more active As reduction, which was one of the mechanisms through which AM fungi mitigate As phytotoxicity. Our study has revealed the role of aerobic microorganism AM fungi in regulating As translocation in wetland plants and supports the involvement of AM fungi in alleviating plant As stress in anaerobic wetlands.
Velopharyngeal Incompetence in Musicians: A State-of-the-Art Review
Authors: Mata-Pose Lucía , Mayo-Yáñez Miguel , Chiesa-Estomba Carlos M. , Lechien Jérôme R. , Vaira Luigi A. , Maniaci Antonino , Saibene Alberto M. , Calvo-Henríquez Christian , Cabo-Varela Irma
Published: October 2023

The velopalatine sphincter is a muscular valve that creates a hermetic seal between the nasopharynx and the oropharynx. It guarantees phonation, swallowing, and breathing (forces expirations). In wind musicians, sphincter closure must be precise during sound generation. Its failure will cause velopharyngeal incompetence (VPI) and the end of professional success. The objective of this article was to conduct a state-of-art review of VPI in wind musicians with a systematic approach based on the PRISMA Statement. The etiology, epidemiology, clinic, diagnosis, and treatment of VPI in wind musicians were evaluated. The research was carried out in different databases (PubMed/MEDLINE, the Cochrane Library, Scielo) and through the Mergullador metasearch engine. A total of 20 publications were selected. VPI is a pathology that affects around one-third of wind musicians according to studies. It causes pharyngeal noises and nasal air emissions during performance. The main etiology seems to be the fatigue of the velopalatine sphincter muscles. The most used diagnostic techniques consist of clinical history, physical examination, and nasofibroscopy. There is no consensus among authors about therapeutic management. Future investigations are necessary to confirm that fatigue of velopalatine sphincter muscles and other factors that increase it are the main causes of VPI in wind musicians.
Applying an Adaptive Neuro-Fuzzy Inference System to Path Loss Prediction in a Ruby Mango Plantation
Authors: Phaiboon Supachai , Phokharatkul Pisit
Published: October 2023

The application of wireless sensor networks (WSNs) in smart agriculture requires accurate path loss prediction to determine the coverage area and system capacity. However, fast fading from environment changes, such as leaf movement, unsymmetrical tree structures and near-ground effects, makes the path loss prediction inaccurate. Artificial intelligence (AI) technologies can be used to facilitate this task for training the real environments. In this study, we performed path loss measurements in a Ruby mango plantation at a frequency of 433 MHz. Then, an adaptive neuro-fuzzy inference system (ANFIS) was applied to path loss prediction. The ANFIS required two inputs for the path loss prediction: the distance and antenna height corresponding to the tree level (i.e., trunk and bottom, middle, and top canopies). We evaluated the performance of the ANFIS by comparing it with empirical path loss models widely used in the literature. The ANFIS demonstrated a superior prediction accuracy with high sensitivity compared to the empirical models, although the performance was affected by the tree level.
Evolution of the Online Grocery-Shopping Experience during the COVID-19 Pandemic: An Empiric Study from Portugal. Comment on Gomes, S.; Lopes, J.M. Evolution of the Online Grocery Shopping Experience during the COVID-19 Pandemic: Empiric Study from Portugal. J. Theor. Appl. Electron. Commer. Res. 2022, 17, 909–923
Authors: Van Hove Leo
Published: October 2023

This comment points out that Lopes and Gomes, in their study on Portugal, erroneously conclude from their results that “being female negatively influences the online grocery shopping experience during the COVID-19 pandemic”. In fact, gender is insignificant.
Arterial and Venous Pressure Monitoring during Cardiopulmonary Resuscitation for Out-of-Hospital Arrests: Four Case Reports
Authors: Onishi Hirokazu , Matsuyama Tasuku , Yasutake Yuki , Inaba Daichi , Katsue Tatsuji , Nagama Masaki , Iwasaki Yuto , Kano Hitoshi
Published: October 2023

Background: A new physiological monitoring system that simultaneously measures femoral arterial pressure, femoral venous pressure, and cerebral tissue oxygen saturation during CPR was used to evaluate the quality of cardiopulmonary resuscitation. In this case report, we would like to present four representative cases with this physiological monitoring system during CPR. Cases: We invasively measured femoral arterial pressure and femoral venous pressure if catheters were immediately inserted into the femoral artery and femoral vein for potential candidates who required extracorporeal cardiopulmonary resuscitation but did not receive such interventions. We presented several cases, including two cases in which cardiopulmonary resuscitation resulted in higher femoral arterial pressure compared to femoral venous pressure, an upward trend in cerebral tissue oxygen saturation values was observed, and both instances achieved the return of spontaneous circulation. In contrast, we also presented two patients with significant increases in femoral venous pressure and low cerebral tissue oxygen saturation values. In both cases, the return of spontaneous circulation was not achieved. Conclusions: We presented cases in which the femoral venous pressure exceeded the femoral arterial pressure using a simultaneous physiological monitoring system to monitor arterial pressure, venous pressure, and cerebral tissue oxygen saturation during cardiopulmonary resuscitation. Further case accumulations will be necessary to assess the variations in hemodynamic status during cardiopulmonary resuscitation and the association between each hemodynamic status and outcomes after cardiac arrest.
Spatiotemporal Changes in Water Storage and Its Driving Factors in the Three-River Headwaters Region, Qinghai–Tibet Plateau
Authors: Zhao Linlin , Chen Rensheng , Yang Yong , Liu Guohua , Wang Xiqiang
Published: October 2023

Water storage (WS) is a crucial terrestrial ecosystems service function. In cold alpine regions (CAR), the cryosphere elements are important solid water resources, but the existing methods for quantitatively assessing WS usually ignore cryosphere elements. In this study, a revised Seasonal Water Yield model (SWY) in the Integrated Valuation of Ecosystem Services and Trade-offs (InVEST), which considers the effects of frozen ground (FG) and snow cover (SC) on WS, was employed to estimate the spatiotemporal distribution and changes in WS in the Three-Rivers Headwaters region (TRHR) from 1981 to 2020. Sensitivity analyses were conducted to understand the overall effects of multiple factors on WS, as well as the dominant driving factors of WS change at the grid scale in the TRHR. The results show that (1) the WS in the TRHR generally increased from 1981 to 2020 (0.56 mm/year), but the spatial distribution of WS change varied greatly, with a significant increasing trend in the northwest part and a significant decreasing trend in the southeast part. (2) In the last 40 years, increased precipitation (Pre) positively affected WS, while increased potential evapotranspiration (ET0) reduced it. Increased permeability caused by degradation of frozen ground increased WS, while snow cover and LULC changes reduced it. (3) In the TRHR, Pre primarily affected the WS with the largest area ratio (32.62%), followed by land use/land cover (LULC) (19.69%) and ET0 (18.49%), with FG being fourth (17.05%) and SC being the least (6.64%). (4) The highly important and extremely important zones generally showed a decreasing trend in WS and should be treated as key and priority conservation regions. It is expected that this research could provide a scientific reference for water management in the TRHR.
The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics
Authors: Saxami Georgia , Kerezoudi Evangelia , Eliopoulos Christos , Arapoglou Dimitrios , Kyriacou Adamantini
Published: October 2023

The human gut microbiota (GM) is a complex microbial ecosystem that colonises the gastrointestinal tract (GIT) and is comprised of bacteria, viruses, fungi, and protozoa. The GM has a symbiotic relationship with its host that is fundamental for body homeostasis. The GM is not limited to the scope of the GIT, but there are bidirectional interactions between the GM and other organs, highlighting the concept of the “gut–organ axis”. Any deviation from the normal composition of the GM, termed ”microbial dysbiosis”, is implicated in the pathogenesis of various diseases. Only a few studies have demonstrated a relationship between GM modifications and disease phenotypes, and it is still unknown whether an altered GM contributes to a disease or simply reflects its status. Restoration of the GM with probiotics and prebiotics has been postulated, but evidence for the effects of prebiotics is limited. Prebiotics are substrates that are “selectively utilized by host microorganisms, conferring a health benefit”. This study highlights the bidirectional relationship between the gut and vital human organs and demonstrates the relationship between GM dysbiosis and the emergence of certain representative diseases. Finally, this article focuses on the potential of prebiotics as a target therapy to manipulate the GM and presents the gaps in the literature and research.
Emerging Technologies within Spine Surgery
Authors: Foley David , Hardacker Pierce , McCarthy Michael
Published: October 2023

New innovations within spine surgery continue to propel the field forward. These technologies improve surgeons’ understanding of their patients and allow them to optimize treatment planning both in the operating room and clinic. Additionally, changes in the implants and surgeon practice habits continue to evolve secondary to emerging biomaterials and device design. With ongoing advancements, patients can expect enhanced preoperative decision-making, improved patient outcomes, and better intraoperative execution. Additionally, these changes may decrease many of the most common complications following spine surgery in order to reduce morbidity, mortality, and the need for reoperation. This article reviews some of these technological advancements and how they are projected to impact the field. As the field continues to advance, it is vital that practitioners remain knowledgeable of these changes in order to provide the most effective treatment possible.
Exosomes in Cancer Progression and Therapy Resistance: Molecular Insights and Therapeutic Opportunities
Authors: Wandrey Madita , Jablonska Jadwiga , Stauber Roland H. , Gül Désirée
Published: October 2023

The development of therapy resistance still represents a major hurdle in treating cancers, leading to impaired treatment success and increased patient morbidity. The establishment of minimally invasive liquid biopsies is a promising approach to improving the early diagnosis, as well as therapy monitoring, of solid tumors. Because of their manifold functions in the tumor microenvironment, tumor-associated small extracellular vesicles, referred to as exosomes, have become a subject of intense research. Besides their important roles in cancer progression, metastasis, and the immune response, it has been proposed that exosomes also contribute to the acquisition and transfer of therapy resistance, mainly by delivering functional proteins and RNAs, as well as facilitating the export of active drugs or functioning as extracellular decoys. Extensive research has focused on understanding the molecular mechanisms underlying the occurrence of resistance and translating these into strategies for early detection. With this review, we want to provide an overview of the current knowledge about the (patho-)biology of exosomes, as well as state-of-the-art methods of isolation and analysis. Furthermore, we highlight the role of exosomes in tumorigenesis and cancer treatment, where they can function as therapeutic agents, biomarkers, and/or targets. By focusing on their roles in therapy resistance, we will reveal new paths of exploiting exosomes for cancer diagnosis and treatment.
Simulation Study on the Influence of a Laser Power Change on the Residual Stress of a Laser-Melting RuT300 Valve Seat
Authors: Tan Wendan , Pang Ming
Published: October 2023

In order to effectively suppress the cracking induced by the excessive residual stress of a laser-melting RuT300 valve seat, the influence of a laser power change on the residual stress was studied by constructing a finite element simulation model of a new power valve seat. The absorption rate of the laser energy on the surface of the material and the change in thermophysical parameters with temperature were taken into account in the model. The results show that the melting and phase-change-hardening areas can be obtained by the laser-melting process. With the increase in laser power, the peak temperature of the molten pool increased almost linearly. The melting zone area and the phase-change-hardening zone depth increased. When the laser power was increased from 2000 to 2600 W, the peak temperature of the laser-melting RuT300 valve seat increased from 2005.09 to 2641.93 °C, the maximum depth of the melting area increased from 0.55 to 0.86 mm, the maximum width of the melting area increased from 3.42 to 4.21 mm, and the maximum depth of the phase-change-hardening area increased from 0.55 to 0.64 mm. The circumferential residual tensile stress in the melting area was much higher than in the radial and axial directions. Along the laser scanning direction, the residual stress in the melting area increased as a whole, and the residual stress in the laser-scanning finishing area greatly increased. With the increase in laser power, the circumferential residual stress at the previous scanning moment decreased, and at the closing moment of the scan, the circumferential residual stress increased with the increase in laser power.
Strength Classification of Wooden Chairs under Cyclic Loads Based on an Experimental Study
Authors: Diler Harun , Kasal Ali , Kuşkun Tolga , Erdil Yusuf Ziya , Güray Ersan
Published: October 2023

This study aimed to assess the cyclic load capacity of wooden chairs and subsequently categorize them based on their performance. A diverse selection of chair models was randomly procured from commercial markets. These chairs underwent performance testing, utilizing the cyclic stepped increasing loading method, with adherence to the standards set forth by the American Library Association Technology Reports (ALA). The study evaluated 315 chairs, encompassing 21 chair models. Each chair model underwent five replications of testing across three different loading directions. The resulting dataset of numerical values was subjected to statistical analyses, facilitating the categorization of chairs based on their strength under cyclic loads. Notably, the study revealed substantial variations in the load capacity among different chair models. As a consequence of this investigation, the study established acceptable design load thresholds. For instance, concerning front-to-back loading, it was determined that the chairs with cyclic load capacities ranging from 932 to 1449 N fell within the category of low-strength, between 1450 and 1968 N were classified as medium-strength (suitable for domestic use), and the chairs with cyclic load capacities exceeding 1968 N were considered to possess high strength (intended for hotel lobbies, restaurants, libraries, etc.). Similarly, for back-to-front loading performance, the study identified the chairs with cyclic load capacities between 625 and 895 N as low-strength, 896 and 1167 N as medium-strength, and the chairs with loads surpassing 1168 N as high-strength. The performance thresholds for side thrust loads were as follows: low-strength encompassed the cyclic load capacities ranging from 649 to 934 N, medium-strength spanned the cyclic load capacities between 935 and 1221 N, and high-strength entailed 1222 N and above. Notably, the classification devised in this study is closely aligned with the widely accepted and internationally recognized ALA specification. This strong consistency with global standards reinforces the reliability and applicability of the classification system developed in this research. In conclusion, this study enhances understanding of wooden chair strength performance and offers practical insights that lead to higher-quality products and improved consumer satisfaction. Its recommendations can potentially drive positive change within the industry and benefit manufacturers and consumers.
Practical Approach for Determining Material Parameters When Predicting Austenite Grain Growth under Isothermal Heat Treatment
Authors: Razali Mohd Kaswandee , Abd Ghawi Afaf Amera , Irani Missam , Chung Suk Hwan , Choi Jeong Muk , Joun Man Soo
Published: October 2023

An investigation of austenite grain growth (AGG) during the isothermal heat treatment of low-alloy steel is conducted. The goal is to uncover the effect of time, temperature, and initial grain size on SA508-III steel grain growth. Understanding this relationship enables the optimization of the time and temperature of the heat treatment to achieve the desired grain size in the studied steel. A modified Arrhenius model is used to model austenite grain size (AGS) growth distributions. With this model, it is possible to predict how grain size will change depending on heat treatment conditions. Then, the generalized reduced gradient (GRG) optimization method is employed under adiabatic conditions to characterize the model’s parameters, providing a more precise solution than traditional methods. With optimal model parameters, predicted AGS agree well with measured values. The model shows that AGS increases faster as temperature and time increase. Similarly, grain size grows directly in proportion to the initial grain size. The optimized parameters are then applied to a practical case study with a similar specimen size and material properties, demonstrating that our approach can efficiently and accurately predict AGS growth via GRG optimization.