bluuebunny/crossref_metadata_2025 huggingface dataset:
Prävalenz der Hypophosphatasie bei adulten Patienten in der Rheumatologie
Authors: Karakostas P. , Dolscheid-Pommerich R. , Hass M. D. , Weber N. , Brossart P. , Schäfer V. S.
Published: April 2021

Hintergrund

Die Hypophosphatasie (HPP) ist eine genetische Erkrankung, die durch eine oder mehrere Mutationen im Gen für alkalische Phosphatase (ALP) verursacht wird, verantwortlich für die Kodierung der gewebespezifischen ALP und für den Mineralisierungsprozess.

Ziel der Arbeit

Bestimmung der Prävalenz der HPP bei rheumatologischen Patienten.

Material und Methoden

Retrospektive Analyse der Krankenakten aller erwachsener Patienten mit pathologisch erniedrigten gesamt ALP-Werten (<35 U/l), die zwischen Januar 2017 und Juni 2019 in der Rheumatologie der Medizinischen Klinik III am Universitätsklinikum Bonn behandelt wurden. Die Analyse wurde in Bezug auf klinische Zeichen sowie auf die Ergebnisse der Gentests für HPP untersucht.

Ergebnisse

Bei 60 von 2289 Patienten (2,62 %) zeigten sich pathologisch niedrige ALP-Werte, bei 30 von ihnen (1,31 %) wurden persistierend niedrige ALP-Werte festgestellt. Bei 19 dieser 30 Patienten wurde ein Gentest für ALP-Genmutationen durchgeführt. Sieben der 19 Patienten (36,84 %) hatten HPP-Zeichen (Insuffizienzfrakturen oder schlechter Zahnstatus seit der Kindheit), alle mit pathologischer ALP-Mutation. Drei dieser Patienten (15,78 %) hatten jeweils eine Insuffizienzfraktur mit normwertiger Knochendichtemessung in der Vorgeschichte. Insgesamt 13 von 19 Patienten wiesen (68,42 %) Mutationen im ALP-Gen auf. Interessanterweise wurde keine Assoziation mit einer Chondrokalzinose festgestellt.

Diskussion

Die HPP scheint eine unterdiagnostizierte Erkrankung mit einem höheren Anteil betroffener Patienten, welche in der Rheumatologie vorstellig werden, zu sein. Daher sollten zukünftige Studien darauf abzielen, ein Diagnostikprotokoll in der klinischen Praxis zu entwickeln.
How Does Temperament in Toddlers at Elevated Likelihood for Autism Relate to Symptoms of Autism and ADHD at Three Years of Age?
Authors: Konke Linn Andersson , Forslund Tommie , Nilsson-Jobs Elisabeth , Nyström Pär , Falck-Ytter Terje , Brocki Karin
Published: April 2021

The current study investigated longitudinal associations between parent-rated temperament, observed exuberance and accelerometer activity level at 18-months and symptoms of ASD and ADHD at 36-months in a sample of 54 children at elevated likelihood for ASD. For the specific parent-rated temperament scales, most observed significant associations appeared to be specific for either ASD or ADHD symptoms. Indeed, by controlling for overlapping symptoms a different pattern of associations emerged. These results illustrate how temperamental measures may signal risk for later ASD versus ADHD symptomatology in infants at elevated likelihood for ASD. In addition, they indicate the potential of adopting a broader view on neurodevelopmental disorders by investigating not only ASD traits, but also co-occurring disorders such as ADHD in samples of elevated likelihood for ASD.
The impact of hypoxia exposure on glucose homeostasis in metabolically compromised humans: A systematic review
Authors: van Hulten Veerle , van Meijel Rens L. J. , Goossens Gijs H.
Published: April 2021

Humans living at a higher altitude are less prone to suffer from impaired glucose homeostasis and type 2 diabetes mellitus (T2DM), which might at least partly be explained by lower oxygen availability at higher altitudes. The present systematic review aimed to provide an overview of the current literature on the effects of hypoxia exposure on glucose homeostasis in metabolically compromised humans. Several databases were searched up to August 10th, 2020. The search strategy identified 368 unique records. Following assessment for eligibility based on the selection criteria, 16 studies were included in this review. Six studies (2 controlled studies; 4 uncontrolled studies) demonstrated beneficial effects of hypoxia exposure on glucose homeostasis, while 10 studies (8 controlled studies; 2 uncontrolled studies) reported no improvement in glucose homeostasis following hypoxia exposure. Notably, passive hypoxia exposure seemed to improve glucose homeostasis, whereas hypoxic exercise training (2–8 weeks) appeared to have no additional/synergistic effects on glucose homeostasis compared to normoxia exposure. Due to the heterogeneity in study populations and intervention duration (acute studies / 2–8 wks training), it is difficult to indicate which factors may explain conflicting study outcomes. Moreover, these results should be interpreted with some caution, as several studies did not include a control group. Taken together, hypoxia exposure under resting and exercise conditions might provide a novel therapeutic strategy to improve glucose homeostasis in metabolically compromised individuals, but more randomized controlled trials are warranted before strong conclusions on the effects of hypoxia exposure on glucose homeostasis can be drawn.
Street-level green spaces support a key urban population of the threatened Hispaniolan parakeet Psittacara chloropterus
Authors: Geary Matthew , Brailsford Celia J. , Hough Laura I. , Baker Fraser , Guerrero Simon , Leon Yolanda M. , Collar Nigel J. , Marsden Stuart J.
Published: April 2021

While urbanisation remains a major threat to biodiversity, urban areas can sometimes play an important role in protecting threatened species, especially exploited taxa such as parrots. The Hispaniolan Parakeet Psittacara chloropterus has been extirpated across much of Hispaniola, including from most protected areas, yet Santo Domingo (capital city of the Dominican Republic) has recently been found to support the island’s densest remaining population. In 2019, we used repeated transects and point-counts across 60 1 km2 squares of Santo Domingo to examine the distribution of parakeets, identify factors that might drive local presence and abundance, and investigate breeding ecology. Occupancy models indicate that parakeet presence was positively related to tree species richness across the city. N-Mixture models show parakeet encounter rates were correlated positively with species richness of trees and number of discrete ‘green’ patches (> 100 m2) within the survey squares. Hispaniolan Woodpecker Melanerpes striatus, the main tree-cavity-producing species on Hispaniola, occurs throughout the city, but few parakeet nests are known to involve the secondary use of its or other cavities in trees/palms. Most parakeet breeding (perhaps 50–100 pairs) appears to occur at two colonies in old buildings, and possibly only a small proportion of the city’s 1500+ parakeets that occupy a single roost in street trees breed in any year. Our models emphasise the importance of parks and gardens in providing feeding resources for this IUCN Vulnerable species. Hispaniola’s urban centres may be strongholds for populations of parakeets and may even represent sources for birds to recolonise formerly occupied areas on the island.
Social Darwinism
Authors: O'Connell Jeffrey , Ruse Michael
Published: April 2021

This Element is a philosophical history of Social Darwinism. It begins by discussing the meaning of the term, moving then to its origins, paying particular attention to whether it is Charles Darwin or Herbert Spencer who is the true father of the idea. It gives an exposition of early thinking on the subject, covering Darwin and Spencer themselves and then on to Social Darwinism as found in American thought, with special emphasis on Andrew Carnegie, and Germany with special emphasis on Friedrich von Bernhardi. Attention is also paid to outliers, notably the Englishman Alfred Russel Wallace, the Russian Peter Kropotkin, and the German Friedrich Nietzsche. From here we move into the twentieth century looking at Adolf Hitler - hardly a regular Social Darwinian given he did not believe in evolution - and in the Anglophone world, Julian Huxley and Edward O. Wilson, who reflected the concerns of their society.
Mobility and Identity in Chaucer s Canterbury Tales
Authors: Wright Sarah Breckenridge
Published: April 2021

The movement of the pilgrims in the Tales explored both practically and metaphorically, showing it to be an expression of identity.
Research on improvement and optimisation of modelling method of China’s civil aircraft market demand forecast model
Authors: Zhang Y. , Cao K. , Dong W.
Published: April 2021

With the development of China’s economy, China’s aviation market has expanded, and related industries have also developed rapidly. For the long-term development of the industry, many countries and enterprises began to make demand forecasts with different levels for the product market. The same is true for China’s civil aircraft-related industries. There are a variety of predictive models, but not all of them are appropriate for the prediction of civil aircraft market demand. This paper introduces a variety of modelling methods for forecasting models, including time series forecasting models and causal analysis forecasting models. The contribution of our work is the adoption of a new coefficient determination method to establish a variable-weight combination forecasting model, which greatly improves the forecasting accuracy. In addition, we also propose a new and more stable prediction model, the chain prediction model. Simulation prediction is carried out for each model in this work. Through the analysis and comparison of the prediction results, we conclude that the prediction effects of the variable weight combination prediction model and the chain prediction model are superior to those of other single prediction models. The chain prediction model in particular has better performance in medium- and long-term prediction, compared with the other prediction models. Finally, the model is applied to predict the demand of Chinese civil aircraft in the next 20 years, which confirms that the Chinese civil aircraft market will expand in the future.
An Undervalued Archaeological Resource: Social Aspects of Bronze Age Textile Production in the Eastern Iberian Peninsula
Authors: Basso Rial Ricardo E. , Jover Maestre Francisco Javier , López Padilla Juan Antonio
Published: April 2021

According to Childe, the Bronze Age in Europe is thought to be the first ‘golden age’ in European history. The development of metallurgy, clearly associated with the production of weapons, and the expansion of exchange networks covering all types of goods are considered essential in the process of consolidation of social elites, and, by extension, of social inequalities. The significance of textile production has, however, been undervalued as a specialized craft and as a manufacturing process that creates cultural differences and signals social inequalities. Being associated with domestic contexts rather than with specialized workshops, textile production in the eastern Iberian Peninsula has been underestimated; it is addressed here, as is its potential importance in societies immersed in a process of social stratification.
Paleoecology of naticid–molluscan prey interaction during the Late Jurassic (Oxfordian) in Kutch, India: evolutionary implications
Authors: Bardhan Subhendu , Saha Sandip , Das Shiladri S. , Saha Ranita
Published: April 2021

We document and quantify one of the oldest predator–prey interactions between naticid gastropods and molluscan prey, on the basis of drill holes in shells, from the Late Jurassic (Oxfordian) beds of Kutch, western India. Previously, many workers recorded naticid-like drill holes on prey taxa from the Triassic and the Jurassic, but in the absence of associated naticid body fossils, they remained equivocal.

The present gastropod community is dominated by turritellines (98% of the sample) that form the turritelline-dominated assemblage, and the naticid drilling predation is restricted almost entirely to turritellines among gastropods. Confamilial naticid predation takes place occasionally. Within the bivalve community, corbulids and nuculids are most abundant and are drilled more often than other taxa. These observations indicate that prey selection was opportunistic and based solely on availability. Drilling intensities at both assemblage and lower taxon levels are low. Behavioral stereotypy of naticid predation in some cases is moderately high.

Turritellines are often the preferred prey of naticid gastropods since the late Early Cretaceous. These two groups form a recurrent association reflecting prey–predator interaction. Here we suggest that both turritellines and naticids evolved during the Jurassic, and the prey–predator interaction between them was established shortly thereafter. Among bivalves, corbulids also became important prey of naticids in the same spatiotemporal framework. Corbulids are older than naticids and first appeared during the Middle Jurassic. After their first encounter with naticids, corbulids evolved conchiolin layers within the valves to resist predation.
Supreme Court Nominations at the Bar of Political Conflict: The Strange and Uncertain Career of the Liberal Consensus in Law
Authors: Downs Donald Alexander
Published: April 2021

Nominations to the US Supreme Court have become increasingly important and contentious in America politics in recent decades. Reasons include the growing significance of constitutional law to the prospects of political power, accompanied by historical developments in the relative power of the competing party coalitions that have placed even more focus on the composition of the Court. Meanwhile, partisan conflict and stalemate have grown in the party systems and among We the People. InThe Long Reach of the Sixties, Laura Kalman explores how the nomination struggles of Presidents Lyndon Johnson and Richard Nixon set the stage for the contemporary conflict besetting nominations and American politics more generally. Building on Kalman’s book, this review essay discusses the political and jurisprudential causes and implications of this conflict, with an eye toward what might lie ahead.
Chronological and rock magnetic constraints on the transition of the Quaternary paleoclimate in the western Qaidam Basin, NE Tibetan Plateau
Authors: Zhang Weilin , Li Tao , Fang Xiaomin , Zhang Tao , Yan Maodu , Zan Jinbo , Yang Yibo , Khatri Dhan Bahadur
Published: April 2021

A closed Quaternary saline paleolake, currently still a lake and named Dalangtan after one of its largest sub-basins, has widely distributed sediments in the western Qaidam Basin, NE Tibetan Plateau. Lacustrine salt minerals and fine sediments from this paleolake provide an environmental record for investigating paleoclimatic evolution in the Asian interior. However, detailed continuous Pliocene–Quaternary paleoclimatic records are broadly lacking from the NE Tibetan Plateau owing to poor exposure of the outcrops in section. For this study, we performed a detailed magnetostratigraphic dating and rock magnetic analysis on a 590-m-long core from the SG-5 borehole in the western Qaidam Basin. The results demonstrate that the lacustrine sediments in the SG-5 borehole were deposited more than ~3.0 Ma. Saline minerals began to increase at 1.2 Ma, and the magnetic susceptibility (χ) also changed at that time; the percentage frequency-dependent magnetic susceptibility was relatively low and uniform throughout the whole core. These observations, combined with the χ, pollen, salt ion, and grain-size records from other boreholes, indicate that the western Qaidam Basin and the greater Asian interior had a significant climate transition at 1.2 Ma during an extreme drought.
BECOMING ΚΛΕΙΝΟΣ IN CRETE AND MAGNA GRAECIA: DIONYSIAC MYSTERIES AND MATURATION RITUALS REVISITED
Authors: McClay Mark F.
Published: April 2021

This article reconsiders the historical and typological relation between Greek maturation rituals and Greek mystery religion. Particular attention is given to the word κλεινός (‘illustrious’) and its ritual uses in two roughly contemporary Late Classical sources: an Orphic-Bacchic funerary gold leaf from Hipponion in Magna Graecia and Ephorus’ account of a Cretan pederastic age-transition rite. In both contexts, κλεινός marks an elevated status conferred by initiation. (This usage finds antecedents in Alcman'sPartheneia.) Without positing direct development between puberty rites and mysteries, the article argues on the basis of shared vocabulary and other ritual elements that age-transitions influenced the ideology of mystery cults. It is further claimed that puberty rites and mysteries performed similar functions in their respective social contexts, despite obvious differences of prestige and visibility. Age-transition rites have been analysed in Bourdieu's terms as ‘rites of institution’, in which young elites were publicly affirmed in civic roles: private mysteries can be described in analogous but opposed terms as rites of ‘counter-institution’, in which familiar ritual language and symbols of elite status were used to construct an alternative ‘imagined community’ of mystery initiates.
A HERACLITEAN ALLUSION TO THE ODYSSEY
Authors: Mackenzie Tom
Published: April 2021

This article applies and defends an intertextual approach to Heraclitus B51 DK, the ‘bow-lyre fragment’. It argues that the fragment alludes to the climactic scene of the Odyssey in which the hero strings the bow and is likened to an expert lyre-player (Od. 21.404–11). It then explores some implications of this point for our understanding of the significance of the fragment, of the sixth-century reception of the Odyssey and of Parmenides’ reception of Heraclitus.
How Alfvén waves energize the solar wind: heat versus work
Authors: Perez Jean C. , Chandran Benjamin D. G. , Klein Kristopher G. , Martinović Mihailo M.
Published: April 2021

A growing body of evidence suggests that the solar wind is powered to a large extent by an Alfvén-wave (AW) energy flux. AWs energize the solar wind via two mechanisms: heating and work. We use high-resolution direct numerical simulations of reflection-driven AW turbulence (RDAWT) in a fast-solar-wind stream emanating from a coronal hole to investigate both mechanisms. In particular, we compute the fraction of the AW power at the coronal base (

$P_\textrm {AWb}$

) that is transferred to solar-wind particles via heating between the coronal base and heliocentric distance

$r$

, which we denote by

$\chi _{H}(r)$

, and the fraction that is transferred via work, which we denote by

$\chi _{W}(r)$

. We find that

$\chi _{W}(r_{A})$

ranges from 0.15 to 0.3, where

$r_{A}$

is the Alfvén critical point. This value is small compared with one because the Alfvén speed

$v_{A}$

exceeds the outflow velocity

$U$

at

$r < r_{A}$

, so the AWs race through the plasma without doing much work. At

$r>r_{A}$

, where

$v_{A} < U$

, the AWs are in an approximate sense ‘stuck to the plasma’, which helps them do pressure work as the plasma expands. However, much of the AW power has dissipated by the time the AWs reach

$r=r_{A}$

, so the total rate at which AWs do work on the plasma at

$r>r_{A}$

is a modest fraction of

$P_\textrm {AWb}$

. We find that heating is more effective than work at

$r < r_{A}$

, with

$\chi _{H}(r_{A})$

ranging from 0.5 to 0.7. The reason that

$\chi _{H} \geq 0.5$

in our simulations is that an appreciable fraction of the local AW power dissipates within each Alfvén-speed scale height in RDAWT, and there are a few Alfvén-speed scale heights between the coronal base and

$r_{A}$

. A given amount of heating produces more magnetic moment in regions of weaker magnetic field. Thus, paradoxically, the average proton magnetic moment increases robustly with increasing

$r$

at

$r>r_{A}$

, even though the total rate at which AW energy is transferred to particles at

$r>r_{A}$

is a small fraction of

$P_\textrm {AWb}$

.
Acoustic differentiation of allophones of /aɪ/ in Chicagoland English: Statistical comparison of formant trajectories
Authors: Hualde José Ignacio , Barlaz Marissa , Luchkina Tatiana
Published: April 2021

Diphthongs have a dynamic formant structure. Nevertheless, many quantitative studies of diphthongs are based on measurements at only two points, somewhere in the nucleus and somewhere in the glide. The question arises as to whether analyses based on values at only two points provide an adequate understanding of the dynamics of diphthongs. Wieling (2018) mentions the analysis of /aɪ/ raising in Chicago English in Hualde, Luchkina & Eager (2017) as one of several examples of recent studies where potentially interesting patterns may have been missed because of limited sampling of formant values, and proposes using Generalized Additive Mixed Models (GAMM) to allow a more complete understanding of diphthong dynamics. In this paper, we examine the acoustic nature of the (quasi-)phonemic differentiation between two originally allophonic variants of the diphthong /aɪ/ in the US English of Chicago and the surrounding area. We offer an acoustic analysis based on full formant trajectories of diphthongs with data obtained from a group of 53 speakers. The results of a GAMM analysis are then compared with those obtained in Hualde et al. (2017), which considered values at only two points and from a smaller set of speakers (17). We also discuss the main advantages of GAMM analysis over other techniques that have being proposed for the analysis of differences in vowel formant dynamics.
Trans-vocalic coronal consonant coarticulation in Central Arrernte: An electro-palatographic study
Authors: Tabain Marija , Beare Richard
Published: April 2021

This study examines trans-vocalic CVC coarticulation of the coronal (dental, alveolar, retroflex and (alveo-)palatal) stop, nasal and lateral consonantsof Arrernte, an Aboriginal language of Central Australia, using electro-palatographic (EPG) recordings of continuous speech. Coronal consonants are known to be more coarticulatorily resistant than peripheral consonants such as bilabials and velars, and this study teases out the coarticulatory differences between these four coronal places of articulation. Results confirm findings from previous studies that laminal consonants (dental and alveo-palatal) are broadly more coarticulatorily aggressive than apical consonants (alveolars and retroflexes), with the alveolars the least resistant to coarticulation. Dental consonants exert fronting effects on both preceding and following consonants, a result consistent with previous acoustic results for these sounds. Similarly, alveo-palatal consonants show both anticipatory and carryover effects, though their exact coarticulatory effect depends on the affected consonant place and manner. The retroflex consonants exert strong fronting effects on thefollowingconsonant, and it is suggested that this is due to the anterior release of retroflexes following ballistic forward movement during closure. There is also some evidence of a retraction effect of retroflexes onprecedingconsonants. Despite this evidence of coarticulatory aggression, retroflexes are particularly affected by preceding and following palatals: in these cases, the retroflex articulation becomes more forward, and dorsal contact for the retroflex is increased. In sum, by examining speech in an understudied language, we learn that there are still greater complexities in the co-ordination of consonants produced using the tongue tip and blade.
Plumbing the Depths: The Changing (Socio-Demographic) Profile of UK Poverty
Authors: EDMISTON DANIEL
Published: April 2021

Official statistics tend to rely on a headcount approach to poverty measurement, distinguishing ‘the poor’ from the ‘non-poor’ on the basis of an anchored threshold. Invariably, this does little to engage with the gradations of material hardship affecting those living, to varying degrees, below the poverty line. In response, this paper interrogates an apparent flatlining in UK poverty to establish the changing profile of poverty, as well as those most affected by it. Drawing on the Family Resources survey, this paper reveals an increasing depth of poverty in the UK since 2010, with bifurcation observable in the living standards of different percentile groups below the poverty line. In addition, this paper demonstrates substantial compositional changes in the socio-demographic profile of (deep) poverty. Since 2010, the likelihood of falling into deep poverty has increased for women, children, larger families, Black people and those in full-time work. Within the context of COVID-19, I argue there is a need to re-think how we currently conceptualise poverty by better attending to internal heterogeneity within the broader analytical and methodological category of ‘the poor’. Doing so raises pressing questions about the prevailing modes of poverty measurement that tend to frame and delimit the social scientific analysis of poverty, as well as the policies deemed appropriate in tackling it.
The role of social communication technologies in cognition and affect in older adults
Authors: Resor Jessica , Cooke Steph , Katz Benjamin
Published: April 2021

Affect and cognition have both been associated with communication across one's social network during ageing. Thus, it is important to consider how communication varies by different aspects of one's social network, and by communication mode, including phone, email and social media. This study aimed to investigate the relationship between technology-mediated communication, depression and an executive function-related fluid-reasoning measure among older adults. Data were drawn from the Health and Retirement dataset's 2016 wave. Hierarchical regression analyses were conducted to examine the link between communication modes (phone, email and social media) with children, family and friends with a fluid-reasoning cognition measure and Center for Epidemiologic Studies Depression Scale, controlling for demographic covariates, among 3,798 older American adults. Phone and email communication, but not social media, were significantly related to depression and cognition. The model fit was considerably stronger for the analyses with cognition than depression. Curvilinear associations were found for communication via phone and email with cognition, suggesting moderate amounts of communication by phone and email across social groups were most closely linked with higher scores on fluid reasoning. For depression, curvilinear relationships were found for talking on the phone with family and friends, and emailing for children and family, indicating that moderate communication levels revealed the lowest depression levels. Implications for how older adults’ social support may contribute to depression and cognition status are discussed.
Theatre production: a positive metaphor for dementia care-giving
Authors: Brown Wilson Christine , Hinson Jan , Wilson Jacinda L. , Power Stephanie , Hinson Daniel , Petriwskyj Andrea
Published: April 2021

Language can shape and reinforce attitudes and stereotypes about living with dementia. This can happen through use of metaphors. However, common metaphors may not capture the complexity of experience of dementia from the perspective of the individual person or a family carer. This paper presents an alternative metaphor – that of a theatre production – based on the strategies used by carers to support people with dementia to live well in the community. We conducted face-to-face semi-structured interviews with 12 family members caring for someone with dementia in the community in Queensland, Australia. Our aim was to explore the strategies these carers used to provide support. Interview recordings were fully transcribed and thematically analysed. We identified positive care-giving strategies that described multiple roles that carers fulfilled as they felt increasingly responsible for day-to-day decision making. Family carers explained how they supported the person with dementia to remain a central character in their life and continued to support the person to be themselves. To achieve this, family carers embodied roles that we identified as similar to roles in a theatre production: director, stage manager, supporting cast, scriptwriter, and costume designer and wardrobe manager. Our metaphor of a theatre production offers a fresh perspective to explore the experience of informal care-giving in the context of dementia.
Re-imagining care transitions for people with dementia and complex support needs in residential aged care: using co-designed sensory objects and a focused ethnography to recognise micro transitions
Authors: Smith Louisa , Phillipson Lyn , Knight Pat
Published: April 2021

The concept of transition is often used in health and lifecourse research to understand a significant movement from one state or place to another. While people with dementia experience more major transitions than their peers, they are often excluded from transitional care research. This study set out to develop meaningful transitional supports for people with dementia and complex support needs who were undertaking a significant planned geographical transition from their current residential aged care facility to a new purpose-built facility. Using the language of complex support needs acknowledges that participants in this study have a breadth and depth of need, including cognitive, physical, psycho-social and communication impairmentsandsocial and cultural disadvantage associated with ageing, institutionalisation and social isolation. To support their move, Participatory Action Research was used to support the co-creation of transitional objects (personalised scarves and blankets) with 15 people with dementia, their families and care staff. Whilst these objects were useful in supporting transition, it was not in the way we imagined. Whilst our initial focus had been on supporting a significant geographical transition, rather it was four types of micro transitions in which the transitional objects were used: small physical transitions (from one place to another); social transitions (entering or exiting personal interactions); activity transitions (moving between activities); and time travel (moving between different times). Reimagining transitions from the perspective of people with dementia and complex support needs involves the recognition of the need for supports for micro as well as macro transitions. Personalised objects to support these everyday micro transitions have the potential to make the lives of people with dementia and complex support needs more manageable, meaningful and comprehensible. Reimagining transitions in dementia in this way helps us reimagine dementia itself, as a constantly fluid, dynamic and responsive series of moments which also has implications for the re-imagination of dementia care.
Impacts of World Englishes on local standardized language proficiency testing in the Expanding Circle
Authors: Zhang Qiusi
Published: April 2021

The world Englishes (WEs) paradigm describes the spread of English in three concentric circles (Kachru, 1985) – the Inner Circle (e.g., the USA, UK, and Australia), the Outer Circle (e.g. India, Philippines, and Singapore), and the Expanding Circle (e.g. China, Indonesia, and Thailand). With Englishization and nativization outside the Inner Circle and the changing demographics of English users (e.g. non-native speakers [NNSs] considerably outnumber the native speakers [NSs] in the Inner Circle [Crystal, 1995; Graddol, 1999], the WEs research strongly advocates to recognize the NNS varieties. Until today, the WEs paradigm has not only posed challenges to, but also encouraged changes in, the language testing (LT) profession that has been traditionally relying on the Inner Circle standard (e.g., Kachru, 1985; Lowenberg, 2002; Davies, Hamp–Lyons & Kemp, 2003; Hu, 2012; Brown, 2014).
Silence matters: The role of pauses during dyadic maternal and paternal vocal interactions with preterm and full-term infants
Authors: KIEPURA Eliza , NIEDŹWIECKA Alicja , KMITA Grażyna
Published: April 2021

This study examined the characteristics of the vocal behaviors of parents and preterm infants, as compared to their term-born peers, at three months of age. Potential links between specific features of parental IDS and infants’ vocal activity were also sought. We analyzed the frequencies and durations of vocalizations and pauses during the dyadic interactions of 19 preterm and 19 full-term infants with their mothers and fathers. The results showed that the duration of the vocalizations was shorter for the preterm than for the full-term infants, regardless of the interactive partner. Mothers vocalized more frequently and for a longer time than fathers, regardless of the group, but only the frequency of paternal utterances was significantly and positively correlated with the frequency and duration of infant vocalizations. Frequent conversational pauses of a relatively short total duration seemed to be related to more active infants’ vocal participation, regardless of prematurity and parent gender.
Porosity in Conformal Dynamical Systems
Authors: CHOUSIONIS VASILEIOS , URBAŃSKI MARIUSZ
Published: April 2021

In this paper we study various aspects of porosities for conformal fractals. We first explore porosity in the general context of infinite graph directed Markov systems (GDMS), and we show that their limit sets are porous in large (in the sense of category and dimension) subsets. We also provide natural geometric and dynamic conditions under which the limit set of a GDMS is upper porous or mean porous. On the other hand, we prove that if the limit set of a GDMS is not porous, then it is not porous almost everywhere. We also revisit porosity for finite graph directed Markov systems, and we provide checkable criteria which guarantee that limit sets have holes of relative size at every scale in a prescribed direction.

We then narrow our focus to systems associated to complex continued fractions with arbitrary alphabet and we provide a novel characterisation of porosity for their limit sets. Moreover, we introduce the notions of upper density and upper box dimension for subsets of Gaussian integers and we explore their connections to porosity. As applications we show that limit sets of complex continued fractions system whose alphabet is co-finite, or even a co-finite subset of the Gaussian primes, are not porous almost everywhere, while they are uniformly upper porous and mean porous almost everywhere.

We finally turn our attention to complex dynamics and we delve into porosity for Julia sets of meromorphic functions. We show that if the Julia set of a tame meromorphic function is not the whole complex plane then it is porous at a dense set of its points and it is almost everywhere mean porous with respect to natural ergodic measures. On the other hand, if the Julia set is not porous then it is not porous almost everywhere. In particular, if the function is elliptic we show that its Julia set is not porous at a dense set of its points.
Pediatric sarcoma survivorship: A call for a developmental cascades approach
Authors: Fantozzi Peter M. , Sprint Gina , Medina Anna Marie
Published: April 2021

Survivors of pediatric sarcomas often experience greater psychological and psychosocial difficulties than their non-afflicted peers. We consider findings related to poorer outcomes from a developmental cascade perspective. Specifically, we discuss how physical, neurocognitive, psychological, and psychosocial costs associated with pediatric sarcomas and their treatment function transactionally to degrade well-being in long-term pediatric sarcoma survivors. We situate the sarcoma experience as a broad developmental threat – one stemming from both the presence and treatment of a life-imperiling disease, and the absence of typical childhood experiences. Ways in which degradation in one developmental domain spills over and effects other domains are highlighted. We argue that the aggregate effect of these cascades is two-fold: first, it adds to the typical stress involved in meeting developmental milestones and navigating developmental transitions; and second, it deprives survivors of crucial coping strategies that mitigate these stressors. This position suggests specific moments of intervention and raises specific hypotheses for investigators to explore.
A possible portrait of Ptolemy I from Dedoplis Gora in Caucasian Iberia (Georgia)
Authors: Gagoshidze David
Published: April 2021

In 2017, during the archaeological excavations of room N24 of the Palace of Dedoplis Gora (Caucasian Iberia, Georgia), built in the 2nd–1st c. BCE, fragments of a small statuette carved from bone were discovered. The statuette is a miniature sphinx with a human head and may have been an element of furniture. The male head is adorned with the nemes, a headdress worn by pharaohs. In this article, I suggest that the head of the sphinx may portray Ptolemy I Soter, the first king of Ptolemaic Egypt. Some scholars believe that artifacts containing Ptolemaic portraits came to Georgia among diplomatic gifts sent by Mark Antony to Pharnabazos II, for it was he who had close relationships with the Ptolemaic court. In my opinion the bone sphinx with the head of Ptolemy I appeared in Caucasian Iberia together with these items.
The Empirical Evidence of the EU–Russia Failed Strategic Partnership: Did it have a Positive Impact on Bilateral Trade?
Authors: Garashchuk Anna , Isla Castillo Fernando , Podadera Rivera Pablo
Published: April 2021

Many observers were casting doubts about the existence of a strategic partnership between Russia and the European Union long before the annexation of Crimea and the subsequent strained relations between the two blocs. Nevertheless, the main challenge of this article is to prove that there was indeed a positive effect regarding the strategic partnership on bilateral trading – together with such factors as the growth of the Russian and EU GDPs per capita, the devaluation of the Russian currency and the oil price increase – by applying the Gravity Model. Based on this model, it was also confirmed that there was a negative effect of the geographical distance and sanctions between parties on the EU–Russia trade flow. Moreover, we tried to predict by means of the Error Correction Models how EU–Russia bilateral trade would have changed according to a scenario wherein the parties continued being strategic partners, and had the sanctions not been imposed. As such, and by the method described, not only was it empirically confirmed that the major partners would have received the most benefit from the strategic partnership with Russia but even Russia’s smaller trading partners are incurring significant welfare losses from sanctions, along with Russia itself.
Age-Dependency of Cardiometabolic Risk and Protective Factors in Females Living in a Countryside Area of Switzerland
Authors: Lepori Letizia , Radovanovic Dragana , Schoenenberger Andreas W. , Suter Paolo M. , Erne Paul , Parati Gianfranco , Gallino Augusto , Bianchetti Mario G. , Muggli Franco
Published: April 2021

Abstract. We investigated the effect of age on cardiometabolic risk and protective factors in females living in a countryside area of Switzerland. For this cross-sectional analysis, data from 268 female adults, who live in two neighboring countryside villages in Italian-speaking Switzerland were retained. 89 study participants were premenopausal, 82 climacteric and 97 postmenopausal. Television viewing time, short duration of sleep, overweight, blood pressure, levels of atherogenic lipids and glycated hemoglobin significantly increased with age. Walking time also significantly increased with age. Tobacco smoking was more common among premenopausal women. It is concluded that in these countryside villages climacteric and postmenopausal women generally have an unfavorable cardiometabolic risk profile. On the other side, low physical activity and smoking are, compared to premenopausal and climacteric women, less prevalent in postmenopausal women.
CME-Sonografie 97: Sonopathologie der Hüfte
Authors: Tamborrini Giorgio , Bianchi Stefano
Published: April 2021

Zusammenfassung. Hüftschmerzen haben eine breite Differenzialdiagnose. Eine klinische Untersuchung reicht nicht, um die zugrundeliegende Ursache festzustellen. Die Sonografie hilft in den meisten Fällen, die Differenzialdiagnose einzugrenzen, beziehungsweise eine spezifische Diagnose zu stellen. Im Weiteren erlaubt der Ultraschall eine gezielte und anatomisch präzise diagnostische Punktion oder therapeutische Infiltration. Anhand von Beispielen werden unterschiedliche Pathologien nach Region illustriert.
CME: Borrelien-Manifestationen am Bewegungsapparat
Authors: Fiore Vittorio , Rakusa Julia , Fehr Thomas , Wick Jürg
Published: April 2021

Zusammenfassung. Die Lyme-Borreliose ist die häufigste durch Vektoren übertragene Krankheit in der Schweiz und die Lyme-Arthritis die häufigste Manifestation der Borreliose im Spätstadium. Sie stellt sich als Monoarthitis oder Oligoarthritis in grossen Gelenken dar, wobei das Kniegelenk am häufigsten betroffen ist. Das klinische Bild zusammen mit einer positiven Serologie oder Polymerasekettenreaktionen aus Synovialflüssigkeit/Gewebe bestätigt die Diagnose. Wenn in der Anamnese kein Zeckenstich oder Erythema migrans vorliegt, kann die Diagnosestellung aufgrund der vielen Differenzialdiagnosen eine Herausforderung sein. Die Erstbehandlung ist eine verlängerte Therapie mit oralen Antibiotika.
Chromospheric Heating by Magnetohydrodynamic Waves and Instabilities
Authors: Srivastava A. K. , Ballester J. L. , Cally P. S. , Carlsson M. , Goossens M. , Jess D. B. , Khomenko E. , Mathioudakis M. , Murawski K. , Zaqarashvili T. V.
Published: April 2021

The importance of the chromosphere in the mass and energy transport within the solar atmosphere is now widely recognized. This review discusses the physics of magnetohydrodynamic waves and instabilities in large‐scale chromospheric structures as well as in magnetic flux tubes. We highlight a number of key observational aspects that have helped our understanding of the role of the solar chromosphere in various dynamic processes and wave phenomena, and the heating scenario of the solar chromosphere is also discussed. The review focuses on the physics of waves and invokes the basics of plasma instabilities in the context of this important layer of the solar atmosphere. Potential implications, future trends and outstanding questions are also delineated.
Circulation and Cross‐Shelf Exchanges in the Northern Shelf Region of the Southwestern Atlantic: Kinematics
Authors: Combes Vincent , Matano Ricardo P. , Palma Elbio D.
Published: April 2021

A high‐resolution ocean model is used to characterize the circulation and cross‐shelf exchanges in the Brazilian/Uruguayan portion of the southwestern Atlantic shelf. Cross‐shelf exchanges are strongly modulated by the bottom topography. There is ∼1.2 Sv of on‐shelf transport between 21°S and 25.2°S, and ∼1.6 Sv of off‐shelf transport between 35°S and 25.2°S. North of 25.2°S, the cross‐shelf exchanges show a two‐layer structure with an off‐shelf flow in the upper 50m and on‐shelf flow deep below. A Lagrangian diagnostic shows that ∼0.15 Sv of deep waters from the Brazil Current (z > 200 m) are injected into the shelf. Mixing with ambient waters produces a spicier (warmer and saltier) water mass, which is ejected into the open ocean in the southern region. Backward in‐time particle's trajectories analysis reveals that 95% of the southward shelf transport at 32°S originates in the open ocean at 22°S. Our model diagnostics show that there is a very limited connectivity between the shelf regions north and south of Cabo Frio. Correlation analysis shows no significant influence of El Niño Southern Oscillation (ENSO) and Southern Annular Mode (SAM) on the time variability of the cross‐shelf transport. Cross‐shelf transports, however, are significantly correlated with the local wind stress variability.
Correlating Apollo Soil Mineralogical Data With Kaguya Spectral Data for a Global Mineralogical Classification
Authors: Sun Lingzhi , Lucey Paul G. , Taylor G. Jeffrey
Published: April 2021

Although lunar soils contain rock and mineral components from the breakdown of a mixture of rock types, a classification based on the abundances of the major silicate minerals plagioclase, olivine, low‐Ca pyroxene (LCP) and high‐Ca pyroxene can be used to evaluate the major compositional classes that are represented within a given soil. We studied the compositional classes for Apollo 15, 16, and 17 soil samples based on the mineral modal abundances derived by X‐ray diffraction (XRD). Using the XRD results as a ground truth, we determined the compositional classes of the Apollo 15, 16, and 17 sampling stations using mineral maps from the Kaguya Multiband Imager (MI), then mapped areas having compositional classes similar to the sampling stations on regional and global scales. Global distribution of compositional classes was also mapped using MI mineral maps, and the major compositional classes of lunar nonmare surfaces are noritic anorthosite (40%), anorthositic norite (24%), and anorthosite (23%). Our maps show that the lunar highlands and the South Pole‐Aitken (SPA) basin are enriched with noritic materials, indicating the widespread occurrence of LCP‐rich and olivine‐poor assemblages. In contrast to the SPA basin and the highlands, the basin rings of Serenitatis, Crisium, Humorum, Nectaris, Orientale, and Hertzsprung exhibit higher olivine/pyroxene ratios (>2), and we interpret this signature as reflecting a contribution from olivine‐rich upper mantle components.
Soil Chips Help Scientists Spy on Fungal Navigation
Authors: den Hond Bas
Published: April 2021

Soil chips provide a micrometer-resolution window into life underfoot, shedding light on how fungi behave when navigating soil’s mazes.
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
Authors: Silva Vera L. , Saxena Jayeta , Nicolini Francesco , Hoare Joseph I. , Metcalf Stephen , Martin Sarah A. , Lockley Michelle
Published: April 2021

High-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that can circumvent this event. We performed a drug screen with 1177 FDA-approved drugs and identified the hydroxyquinoline drug, chloroxine. In extensive validation experiments, chloroxine restored sensitivity to both cisplatin and carboplatin, demonstrating broad synergy in our range of experimental models of platinum-resistant HGSC. Synergy was independent of chloroxine’s predicted ionophore activity and did not relate to platinum uptake as measured by atomic absorption spectroscopy. Further mechanistic investigation revealed that chloroxine overrides DNA damage tolerance in platinum-resistant HGSC. Co-treatment with carboplatin and chloroxine (but not either drug alone) caused an increase in γH2AX expression, followed by a reduction in platinum-induced RAD51 foci. Moreover, this unrepaired DNA damage was associated with p53 stabilisation, cell cycle re-entry and triggering of caspase 3/7-mediated cell death. Finally, in our platinum-resistant, intraperitoneal in vivo model, treatment with carboplatin alone resulted in a transient tumour response followed by tumour regrowth. In contrast, treatment with chloroxine and carboplatin combined, was able to maintain tumour volume at baseline for over 4 months. In conclusion, our novel results show that chloroxine facilitates platinum-induced DNA damage to restore platinum sensitivity in HGSC. Since chloroxine is already licensed, this exciting combination therapy could now be rapidly translated for patient benefit.