bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Acute Myocardial Infarction with a Single Blood Draw
Authors: Boeddinghaus Jasper , Nestelberger Thomas , Badertscher Patrick , Twerenbold Raphael , Fitze Brigitte , Wussler Desiree , Strebel Ivo , Rubini Giménez Maria , Wildi Karin , Puelacher Christian , du Fay de Lavallaz Jeanne , Oehen Loris , Walter Joan , Miró Òscar , Martin-Sanchez F Javier , Morawiec Beata , Potlukova Eliska , Keller Dagmar I , Reichlin Tobias , Mueller Christian ,   Additional APACE Investigators and Contributors to this article include:, Sabti Zaid , Freese Michael , Stelzig Claudia , Shrestha Samyut , Schaerli Nicolas , Kozhuharov Nikola , Flores Dayana , Lohrmann Jens , Biskup Ewalina , Kloos Wanda , Osswald Stefan , Mueller Deborah , Sazgary Lorraine , López Beatriz , Adrada Esther Rodriguez , Kawecki Damian , Muzyk Piotr , Nowalany-Kozielska Ewa , Parenica Jiri , Ganovská Eva , Meissner Kathrin , Kulangara Caroline , Mahfouz Riham , Hartmann Beate , Ferel Ina , Campodarve Isabel , Rentsch Katharina , von Eckardstein Arnold , Buser Andreas , Geigy Nicolas
Published: January 2019

BACKGROUND

We desired to determine cardiac troponin (cTn) concentrations necessary to achieve a positive predictive value (PPV) of ≥75% for acute myocardial infarction (AMI) to justify immediate admission of patients to a monitored unit and, in general, early coronary angiography.

METHODS

In a prospective multicenter diagnostic study enrolling patients presenting to the emergency department with symptoms suggestive of AMI, final diagnoses were adjudicated by 2 independent cardiologists based on clinical information including cardiac imaging. cTn concentrations were measured using 5 different sensitive and high-sensitivity cTn (hs-cTn) assays in a blinded fashion at presentation and serially thereafter. The diagnostic end point was PPV for rule-in of AMI of initial cTn concentrations alone and in combination with early changes.

RESULTS

Among 3828 patients, 616 (16%) had an AMI. At presentation, 7% to 14% of patients had cTnT/I concentrations associated with a PPV of ≥75%. Adding absolute or relative changes did not significantly further increase the PPV. PPVs increased from 46.5% (95% CI, 43.6–49.4) for hs-cTnT at presentation >14 ng/L to 78.9% (95% CI, 74.7–82.5) for >52 ng/L (P < 0.001), whereas PPVs in higher hs-cTnT strata remained largely unchanged [e.g., 82.4% (95% CI, 77.5–86.7) for >80 ng/L vs 83.9% (95% CI, 76.0–90.1) for >200 ng/L (P = 0.72)]. The addition of early changes in hs-cTnT further increased the PPV up to 60 ng/L, but not for higher concentrations.

CONCLUSIONS

Serial sampling does not seem necessary for predicting AMI and concurrent decision-making in about 10% of patients, as it only marginally increases the PPV for AMI and not in a statistically or clinically significant way.

ClinicalTrials.gov Identifier

NCT00470587.
Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction
Authors: Anand Atul , Shah Anoop S V , Beshiri Agim , Jaffe Allan S , Mills Nicholas L
Published: January 2019

BACKGROUND

The universal definition of myocardial infarction (UDMI) standardizes the approach to the diagnosis and management of myocardial infarction. High-sensitivity cardiac troponin testing is recommended because these assays have improved precision at low concentrations, but concerns over specificity may have limited their implementation.

METHODS

We undertook a global survey of 1902 medical centers in 23 countries evenly distributed across 5 continents to assess adoption of key recommendations from the UDMI. Respondents involved in the diagnosis and management of patients with suspected acute coronary syndrome completed a structured telephone questionnaire detailing the primary biomarker, diagnostic thresholds, and clinical pathways used to identify myocardial infarction.

RESULTS

Cardiac troponin was the primary diagnostic biomarker at 96% of surveyed sites. Only 41% of centers had adopted high-sensitivity assays, with wide variation from 7% in North America to 60% in Europe. Sites using high-sensitivity troponin more frequently used serial sampling pathways (91% vs 78%) and the 99th percentile diagnostic threshold (74% vs 66%) than sites using previous-generation assays. Furthermore, high-sensitivity institutions more often used earlier serial sampling (≤3 h) and accelerated diagnostic pathways. Fewer than 1 in 5 high-sensitivity sites had adopted sex-specific thresholds (18%).

CONCLUSIONS

There has been global progress toward the recommendations of the UDMI, particularly in the use of the 99th percentile diagnostic threshold and serial sampling. However, high-sensitivity assays are still used by a minority of sites, and sex-specific thresholds by even fewer. Additional efforts are required to improve risk stratification and diagnosis of patients with myocardial infarction.
Análise do Planejamento Tributário na Perspectiva da Gestão
Authors: Silva Francisco Fabiano Valença da , Macêdo Maria Erilúcia Cruz
Published: January 2019

Esta pesquisa objetiva analisar como ocorre o planejamento tributário nas empresas, na perspectiva da gestão, tendo em vista que o administrador é o grande responsável por todo o processo de planejamento dentro da empresa. Para verificação do problema proposto foi realizada uma pesquisa aplicada, descritiva, Bibliográfica, com abordagem qualitativa. Os resultados apontam que as organizações de forma geral não realizam o planejamento tributário, nem tampouco o seu contador participa ou realiza esse tipo de planejamento. Salienta-se que o Planejamento tributário é capaz de contribuir de forma significativa com a redução dos custos da empresa, por meio de um estudo detalhado não somente dos tributos que deverão ser pagos, como também da escolha do regime de tributação mais adequado e da análise minuciosa dos demonstrativos e da própria legislação.
Gerenciamento de Resíduos Sólidos e a Aplicação da Logística Reversa no Segmento da Construção Civil
Authors: Matos João Paulo Cavalcante , Alencar Tharsis Cidália De Sá Barreto Diaz de
Published: January 2019

A Construção Civil representa uma das mais importantes atividades para o desenvolvimento e fomento econômico de um país. Porém, este é um dos setores que mais impacta e agride ao meio ambiente, isto, quer seja pela grande exploração de recursos naturais, pelas mudanças das paisagens ou mesmo pela produção de resíduos oriundos dos canteiros de obras. Este último aspecto, constituirá a problemática abordada ao longo deste estudo. Nessa perspectiva, o artigo ora exposto tem por objetivo geral investigar a aplicação da logística reversa no segmento da construção civil, com ênfase nas alternativas adotadas para a segregação, coleta e disposição destes materiais. No que tange a metodologia, o estudo em questão utilizou a abordagem descritiva, de cunho qualitativo, sendo esta uma pesquisa bibliográfica, a qual foi desenvolvida com base em livros, artigos, dentre outras publicações. Observou-se que as operações desempenhadas no âmbito da construção civil geram, predominantemente, o montante da parcela de resíduos sólidos urbanos encontrados nos centros urbanos. Constatou-se que a gestão de resíduos provenientes da construção civil torna-se uma ferramenta de suma relevância, haja vista estabelecer diretrizes para a disposição dos resíduos em locais apropriados, emergindo como um instrumento efetivo para minimizar os impactos sofridos pela natureza, podendo promover uma redução substancial no consumo de recursos naturais não renováveis; além de reduzir áreas destinadas a aterro, isto pela minoração da massa de resíduos para reuso e reciclagem; bem como auxilia a atenuar os índices de poluição; dentre outros benefícios.
Análise de Perigos e Riscos Microbiológicos Associados à Comercialização de Saladas de Frutas por Ambulantes em de Vitória da Conquista – BA
Authors: Cacique Marciene Antunes Campos , Fogaça Larissa Costa Silva , Reis Rosilaine Barbosa Silva , Amorim Maquel Matos Santos
Published: January 2019

As saladas de frutas são comercializadas principalmente em lanchonetes, quiosques e por ambulantes, sendo estes últimos bastante expressivos neste segmento. O comércio ambulante de alimentos apresenta uma opção de renda para diversas famílias e ao mesmo tempo, aparece como uma escolha para pessoas que necessitam se alimentar de uma maneira rápida e prática. Porém, estes alimentos na maioria das vezes são apresentados em vias públicas, sem o devido cuidado em sua manipulação, expostos à contaminação. Objetivou-se com esta pesquisa averiguar a qualidade microbiológica de saladas de frutas comercializadas por vendedores ambulantes na cidade de Vitória da Conquista- Bahia. O estudo caracterizou-se como uma pesquisa experimental, descritiva de abordagem quantitativa. As amostras de saladas de frutas comercializadas por vendedores ambulantes (n=5) foram adquiridas em dias alternados, sendo armazenadas em recipientes previamente esterilizados e conduzidas em caixa isotérmicas contendo gelo reciclável em condições assépticas para análises. As análises foram feitas seguindo os padrões e metodologias da Americam Public Health Association (APHA, 2001), descrita no Compendium of Methods for the Microbiological Examination of Foods. As amostras avaliadas apresentaram resultados satisfatórios quanto à presença de Salmonella, pois estas não foram identificadas, assim como os coliformes termotolerantes encontraram-se abaixo do limite permitido pela legislação vigente, atendendo aos padrões preconizados pela RDC nº 12/2001. Entretanto a presença de coliformes totais em quatro das cinco amostras analisadas indicam hábitos higiênicos inadequados no processamento das saladas de frutas, mesmo não tendo limites estabelecidos na legislação para estas, servindo assim como um alerta aos produtores e vendedores ambulantes no atendimento às boas práticas de fabricação.
Pengaruh Pemberian Nasi Beras Merah (Oryza nivara) dan Nasi Beras Hitam (Oryza sativa L.indica) Terhadap Kadar hsCRP Tikus Wistar (Rattus norvegicus) Diabetes Melitus Tipe 2
Authors: Sitanggang Golda Sharon , Ardiaria Martha , Rahadiyanti Ayu
Published: January 2019

Latar belakang: Diabetes Melitus (DM) merupakan penyakit kronik yang disebabkan defisiensi atau resistensi insulin, yang ditandai tingginya konsentrasi glukosa dalam darah. Kadar hsCRP dapat digunakan untuk melihat marker inflamasi yang paling sensitif pada diabetesi. Beras merah dan beras hitam diketahui kaya akan antosianin dan serat yang berpotensi meningkatkan sensitivitas insulin dan mengurangi inflamasi.Tujuan: Mengetahui perbedaan pemberian nasi beras merah dan nasi beras hitam terhadap kadar hsCRP pada tikus wistar DM Tipe 2Metode: Jenis penelitian ini adalah true experimental dengan post test control group design. Besar sampel penelitian 24 ekor tikus wistar jantan, 6 ekor dikondisikan sehat yaitu kelompok K(-) dan 18 ekor tikus dikondisikan DM dengan injeksi STZ 50 mg/kg BB dan 110 NA mg/kg BB. Kemudian tikus DM dibagi menjadi 3 kelompok yaitu kelompok K(+), kelompok perlakuan nasi beras merah (P1) dan kelompok perlakuan nasi beras hitam (P2). Intervensi dilakukan selama 28 hari, kadar hsCRP diukur menggunakan metode ELISA. Analisis statistik menggunakan uji ANOVA dan dilanjutkan dengan uji post hoc Duncan.Hasil: Terdapat perbedaan signifikan kadar hsCRP antar kelompok (p=0,000). Kelompok P1 memiliki kadar hsCRP dengan nilai 18,8±0,50 ng/ml. Kelompok P2 memiliki kadar hsCRP dengan nilai 16,3±0,72 ng/ml.Simpulan: Pemberian nasi beras merah dan nasi beras hitam menunjukkan adanya perbedaan kadar hsCRP secara signifikan. Kadar hsCRP lebih rendah pada kelompok tikus dengan pemberian nasi beras hitam.
Bioactive glass-polycaprolactone fiber membrane and response of dental pulp stem cells in vitro
Authors: Labbaf S. , Houreh A. Baharlou , Rahimi M. , Ting Hung-Kai , Jones Jr. , Nasr-Esfahani Mh
Published: January 2019

The study reports the fabrication and in vitro biological evaluation of a sol-gel derived bioactive glass (BG) / polycaprolactone (PCL) composite fiber membrane, as a potential candidate for bone regeneration applications. The non woven composite mats were prepared by introducing the glass particles into the electrospinning process. Adding the glass improved the homogeneity of the fibers. The apatite forming ability of the membranes in simulated body fluid were evaluated and showed that hydroxyapatite had formed within 21 days in SBF and completely covered the surface of the membrane. In cell culture, dental pulp stem cells adhered proliferated and produced mineralized matrix on the PCL/BG fiber membrane.
Thermomechanical properties of PEGDA and its co-polymers
Authors: Rekowska Natalia , Arbeiter Daniela , Konasch Jan , Riess Alexander , Mau Robert , Eickner Thomas , Seitz Hermann , Grabow Niels , Teske Michael
Published: January 2019

Current research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare.

Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.
The International Year of the Periodic Table 2019
Authors: Reedijk Jan , Tarasova Natalia
Published: January 2019

This year we celebrate the Periodic Table of Chemical Elements in the format proposed by Mendeleev in 1869, and its continued development to this day. This issue of

CI

describes several aspects of the Periodic Table, its history and celebration, and also addresses the pathways to possible new elements. In this preface we address some highlights of the papers and pay attention to the history of events that have led to IYPT2019.
Tribological Behaviour of Polymers in Terms of Plasma Treatment: A Brief Review
Authors: Al-Maliki Hayder , Kalácska Gábor
Published: January 2019

A review to enrich the literature concerning the effect of various plasmas on the tribological behaviour of polymers and monitor the developments of plasma for the modification of polymer surfaces over recent decades using up-to-date data. A comparative study of plasmas was conducted to identify the most useful and efficient ones which facilitate optimal improvements with regard to the characterizations of polymer surfaces and tribological properties. The studies included in this review strongly suggest that (besides Plasma-Immersion Ion Implantation, PIII) atmospheric plasmas (dielectric barrier discharges, DBD) are an effective technique in terms of modifying the characterizations of polymer surfaces thereby enhancing the tribological behaviour of polymers under different operating conditions that extends the operating life of elements within the machine.
Formation of Glycidyl Esters During The Deodorization of Vegetable Oils
Authors: Bognár Erzsébet , Hellner Gabriella , Radnóti Andrea , Somogyi László , Kemény Zsolt
Published: January 2019

Glycidyl esters are foodborne contaminants formed during the production of fats and oils, especially during the deodorization of palm oil. The hydrolyzed free form of glycidol has been categorized as probably carcinogenic to humans by the World Health Organization’s International Agency for Research on Cancer. The aim of this research was to study the formation of glycidyl esters during the lab-scale deodorization of the three most widely produced seed oils in the world (sunflower, rapeseed and soybean). The effects of two independent factors – temperature and residence time – were analyzed by a 32 full factorial experimental design and evaluated by response surface methodology. In accordance with findings in the literature, the greatest amount of glycidyl esters was formed in the soybean oil matrix. For all three oils, the effects of both residence time and temperature were significant, while the latter was more so. To reduce the formation of glycidyl esters, milder deodorization is required, which is limited because of the purposes sought by the thermal operation and removal of volatile minor components and contaminants.
Predicting the potential distribution of the lesser-known endemic Madras hedgehog Paraechinus nudiventris (Order: Eulipotyphla, Family: Erinaceidae) in southern India
Authors: Kumar Brawin , Babu Santhanakrishnan , Kumara Honnavalli N.
Published: January 2019

The Madras hedgehog (Paraechinus nudiventris) is a less-known insectivorous mammal, endemic to southern India, and known from the states of Tamil Nadu, Kerala, Karnataka, Andhra Pradesh and Telangana. The nocturnal habit, small body size and elusive nature of P. nudiventris have resulted in limited studies on its habitat selection and ecology. The confirmed locations of P. nudiventris from our field surveys and existing sight records were pooled. These geocoordinates were then used as the “occurrence location” to predict the potential distribution range of P. nudiventris in southern India based on a set of climatic and terrain variables using the MaxEnt algorithm. The predicted model shows the suitable ecological conditions in the districts of Erode, Tirunelveli, Tuticorin, Coimbatore and Tiruppur in Tamil Nadu, making them highly probable sites for its presence. Most of the predicted suitable range and high potential range fall in the non-protected semi-dry zones characterized by low annual rainfall with sparse savanna vegetation, lowland [0–750 m above sea level (asl)] and the rural areas of southern Tamil Nadu. Our findings establish the potential distribution range of this species in parts of Karnataka, Andhra Pradesh, Kerala and most of Tamil Nadu.
Chaotic mixing analysis of a novel single-screw extruder with a perturbation baffle by the finite-time Lyapunov exponent method
Authors: Liu Jian , Zhu Xiangzhe
Published: January 2019

The single-screw extruder with a perturbation baffle is a novel piece of equipment for polymer processing, in which the polymer melts undergo complex chaotic mixing. In this paper, from a new Lagrangian perspective, the fluid transporting mechanism in chaotic flow of the unwound screw channel was analyzed based on the finite element method. Firstly, two-dimensional velocity distributions in the unwound screw channel were calculated based on the mesh superposition technique. Fluid particle evolution processes in the extruder were tracked based on the fourth-order Runge-Kutta scheme. The numerical method used in this paper was validated by grid independence and experiments obtained from literature. Moreover, the finite-time Lyapunov exponent (FTLE) and Poincaré sections were adopted to discuss the chaotic mixing in the novel single-screw extruder. The effects of baffle width and height on the manifold structures in the flow dynamic system were analyzed. The results show that the homoclinic point of the manifold structure can give rise to chaotic mixing in the single-screw extruder. The height of the baffle is an important parameter to control the chaotic strength. In a way, increasing the height of the baffle can enlarge the kink scale and increase the stretching and folding actions, which results in the decrease of regular regions and an increase of the mixing efficiency in the single-screw extruder.
Apelin-13 serum levels in type 2 diabetic obese women: possible relations with microRNAs-107 and 375
Authors: Ashoori Mohammad Reza , Rahmati-Yamchi Mohammad , Ostadrahimi Alireza , Pahlavan-Gharebaba Reza , Mobasseri Majid , Bakhtiyari Salar , Zarghami Nosratollah
Published: January 2019

Objective

Apelin, an adipocytokine, is up-regulated by insulin and suppresses pancreatic insulin secretion. One of the key microRNAs in insulin resistance caused by obesity, is microRNA-107. MicroRNA-375 is expressed in the pancreatic islet cells. We aimed to explore apelin-13 and microRNA-107 and 375 in obese women with type 2 diabetes (T2D).

Materials and Methods

Fifty obese women with newly diagnosed T2D and 50 non-diabetic obese women, as controls, were selected. Quantitative PCR and ELISA were used to measure the expression of microRNA-107 and 375 and Apelin-13 concentration, respectively. The role of apelin-13 was investigated in an in vitro model. Apoptosis was evaluated by flow cytometry.

Results

Apelin-13 levels in diabetics were significantly more than controls (p=0.012). The expressions of microRNA-107 and 375 of diabetic group were increased, in comparison to the control group. There was no correlation between apelin-13 and microRNA-107 and 375 in diabetic and control groups. Significant correlations between apelin-13 and serotonin (p<0.001) and estimated average glucose (p<0.02) and insulin (p<0.03) were only observed in the diabetic group.

Conclusion

Serum levels of apelin-13 and circulating microRNA-107 and 375 could be used as biomarkers for diabetes, particularly in obese subjects. However, more study is needed in this field.
Activation of Phox2b-Expressing Neurons in the Nucleus Tractus Solitarii Drives Breathing in Mice
Authors: Fu Congrui , Shi Luo , Wei Ziqian , Yu Hongxiao , Hao Yinchao , Tian Yanming , Liu Yixian , Zhang Yi , Zhang Xiangjian , Yuan Fang , Wang Sheng
Published: January 2019

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal phenotype and circuit mechanism involved in such a physiological function remain incompletely understood. This study focused on the respiratory role of paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons and sought to determine whether selective stimulation of this set of neurons activates breathing in male mice. A Cre-dependent vector encoding a Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into the NTS of Phox2b-Cre transgenic mice. The hM3Dq-transduced neurons were pharmacologically activated in conscious mice while respiratory effects were measured by plethysmography. We demonstrate that chemogenetic stimulation of Phox2b-expressing NTS neurons significantly increased baseline minute volume via an increase in respiratory frequency rather than tidal volume. Chemogenetic stimulation also synergized with moderate CO2stimulation to enhance pulmonary ventilatory response. Selective ablation of Phox2b-expressing NTS neurons notably attenuated a hypercapnic ventilatory response. Moreover, histological evidence revealed that stimulation of Phox2b-expressing NTS neurons increased neuronal activity of the preBötzinger complex. Finally, we presented the neuroanatomical evidence of direct projection of Phox2b-expressing NTS neurons to putative respiratory central pattern generator. Overall, these findings suggest that selective activation of Phox2b-expressing NTS neurons potentiates baseline pulmonary ventilation via an excitatory drive to respiratory central pattern generator and this group of neurons is also required for the hypercapnic ventilatory response.

SIGNIFICANCE STATEMENTThe nucleus tractus solitarii (NTS) has been implicated in the control of breathing. The paired-like homeobox 2b gene (Phox2b) is the disease-defining gene for congenital central hypoventilation syndrome and is restrictively present in brainstem nucleus, including the NTS. Using a chemogenetic approach, we demonstrate herein that selective stimulation of Phox2b-expressing NTS neurons vigorously potentiates baseline pulmonary ventilation via an excitatory drive to respiratory central pattern generator in rodents. Genetic ablation of these neurons attenuates the hypercapnic ventilatory response. We also suggest that a fraction of Phox2b-expressing neurons exhibit CO2sensitivity and presumably function as central respiratory chemoreceptors. The methodology is expected to provide a future applicability to the patients with sleep-related hypoventilation or apnea.
Presentation – Vygotsky’s approach to disability in the context of contemporary debates and challenges: Charting the next steps (“Special Issue – Vygotsky’s Defectology”)
Authors: Stetsenko Anna , Selau Bento
Published: January 2019

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Acoustic emission behaviour of dense sands
Authors: Smith Alister , Dixon Neil
Published: January 2019

Interpretation of acoustic emission (AE) generated by particulate materials has to date been qualitative. The objective of this study was to move the discipline towards quantitative interpretation of AE to enable early warning of serviceability and ultimate limit state failures in the field, and to enhance the instrumentation of element and physical model tests in the laboratory. Results from a programme of drained triaxial tests on dense sands show that: AE generation is proportional to the imposed stress level, imposed strain rate, fabric coordination number and boundary work done; there are two types of AE response at the transition from contractive to dilative behaviour, which was governed by the mean particle size; and AE activity in particulate materials is negligible until the current stress conditions (compression and/or shear) exceed the maximum that has been experienced in the past. Relationships have been quantified between AE and boundary work (i.e. AE generated per Joule) for a unit volume of sand under isotropic compression and shear, and between AE and shear strain rate. An example interpretation framework demonstrates how AE measurements could be used to identify the transition from contractive to dilative behaviour, mobilisation of peak shear strength and quantify accelerating deformation behaviour that typically accompanies shear zone development.
Improving preliminary cost estimation in Indonesia using support vector regression
Authors: Chen Jieh-Haur , Su Yu-Min , Hayati Diana Wahyu , Wijatmiko Indradi , Purnamasari Ragil
Published: January 2019

A typical preliminary cost estimation for a building construction project in Indonesia may take weeks and have an error rate varying from around −13 to +27%. The research objectives of this study were thus to determine the factors that influence cost estimation in Indonesia and to develop a support vector regression model to improve the accuracy and reduce the work hours for preliminary cost estimation. The literature review identified 14 factors that have the most influence on cost estimation in Indonesia. Data collection was carried out to gather information randomly on 104 building cases in Indonesia deemed to contain valid information for the proposed model. The model with a radial basis function kernel was established after data trimming, analysis and normalisation. The proposed model was then evaluated and implemented using fivefold cross-validation and yielded an average accuracy of 96% for preliminary cost estimation of building construction projects. The model’s average accuracy was 87%, it was efficient and resulted in significant time savings.
Utilização de substratos orgânicos na produção de mudas de Eugenia uniflora L.
Authors: Marques Alan Richar Freitas , Costa Alice Lemos , Travessas Amanda Oliveira , Boligon Alexandra Augusti , Vestena Silvane
Published: January 2019

O objetivo deste trabalho foi avaliar o efeito de diferentes substratos na produção e qualidade de mudas de Eugenia uniflora DC. Os tratamentos foram compostos por quatro substratos, sendo: S1) 100 % substrato comercial Plantmax®; S2) 50% substrato comercial Plantmax® + 50% substrato cama de equino; S3) 50% substrato comercial Plantmax® + 50% resíduo do tratamento de esgoto e S4) 50% substrato comercial Plantmax® + 50% resíduo do tratamento de água., sendo realizado análise de alguns parâmetros físico-químico dos substratos. Os tratamentos foram arranjados em delineamento inteiramente casualizado, com cinco repetições com 25 sementes cada. A cada três dias durante 90 dias foram realizadas a contagem de plântulas que emergiram para posterior calculo de índice de velocidade de emergência. Decorridos 180 dias após a semeadura foi calculada a porcentagem de emergência e as demais características biométricas, tais como: comprimento da parte aérea e do sistema radicular, diâmetro do coleto, número de folhas, massas fresca e seca da parte aérea, radicular e total e, ainda foi calculado o índice de qualidade de Dickson, bem como foi quantificado o teor de alguns macro e micronutrientes do sistema radicular, do caule e das folhas. Diante dos resultados obtidos foi observado que o substrato composto de resíduo do tratamento de água se mostrou efetivo a obtenção de mudas viáveis para plantio a campo.
En clave de conflicto: dinámica de la industria regional y trabajo en Mendoza, Argentina
Authors: Canafoglia Eliana Celeste
Published: January 2019

La dinámica de los conflictos laborales ocurridos en la provincia de Mendoza entre 2009 y 2016 evidencia una progresiva visibilización de los límites del crecimiento económico vinculado con la producción industrial y del resquebrajamiento de la anuencia política, económica y laboral. Durante dicho período recrudece la conflictividad laboral: de reclamos centralmente orientados a mejoras salariales y ratificación de los convenios colectivos de trabajo a luchas por fuentes de trabajo, pagos atrasados y despidos. Con el fin de reflexionar sobre las transformaciones socioproductivas en curso, se analiza dicha conflictividad en cuanto a las demandas de los trabajadores, sus acciones y modos de resolución, distinguiendo sectores productivos y actores involucrados.
Honduras: precariedad laboral en la clase asalariada durante el modelo de acumulación neoliberal
Authors: Pineda Talavera Mario Enrique
Published: January 2019

Este trabajo analiza el sostenido proceso de precarización de las relaciones laborales sufrido por la clase asalariada a partir de la configuración del modelo de acumulación neoliberal en Honduras. Analíticamente, la precariedad laboral es considerada como el deterioro y restricción de estatutos laborales centrales para la reproducción de la fuerza de trabajo y la mejora en las condiciones de vida de la masa asalariada. Para ello, se elaboró un índice simple como intento de captación empírica de la precariedad laboral y posteriormente se procedió con la estimación de una regresión logística binaria para conocer los factores determinantes de la condición de precariedad laboral alta en los años 2006, 2010 y 2013.
Lo que queda
Authors: Vera Vega Cristina
Published: January 2019

Ensayo visual "Lo que queda"
El Concierto para Oboe y pequeña Orquesta en re mayor Op. 144 (trV 292) de Richard Strauss. Análisis y estudio del fraseo en la exposición del primer movimiento / The Concert in D major for oboe and small orchestra Op. 144 (TrV 292) of Richard Strauss. Analysis and study phrasing in the first movement
Authors: García Herrera Cecilio
Published: January 2019

A través de este artículo se analiza el fraseo utilizado por Richard Strauss en la exposición del primer movimiento del Concierto para oboe y pequeña orquesta en remayor Op. 144 (TrV 292) en su edición de 1948. La razón de este acercamiento se debe a que por sus características, el fraseo en esta obra exige al oboísta agilidad, flexibilidad y, especialmente, un gran control de la respiración para que su interpretación no lo conduzca a un estado total de agotamiento.
ENTROPİ TABANLI TOPSIS VE VIKOR YAKLAŞIMI İLE AKADEMİSYENLER ÜZERİNDE BİR DUYGUSAL PERFORMANS DEĞERLENDİRME: BARTIN ÖRNEĞİ
Authors: Çelebi Demirarslan Pınar , Küçükönder Hande , Kıngır Said
Published: January 2019

Bu çalışmanın amacı, çok kriterli karar verme
tekniklerinden TOPSIS ve VIKOR yöntemlerini kullanarak; tükenmişlik, iş
tatmini, duygusal emek ve işten ayrılma niyeti iş davranışlarına göre akademik
personelin duygusal performanslarının ölçülmesidir. Akademik personelin
tükenmişlik düzeyini belirleme veya duygusal emeğin etkisi üzerine çalışmalar
yapılmış ve bu çalışmalarda genellikle gelir, cinsiyet, ders yükü vb.
kriterleri ele alınmıştır. Bu çalışmada ise iş davranışları kriter olarak kabul
edilerek personelin duygusal performans değerlemesi yapılmıştır.

 Çalışmanın
araştırma evrenini Bartın Üniversitesi İktisadi ve İdari Bilimler Fakültesi’nde
2015-2016 Bahar Dönemi’nde görev yapan akademik personel oluşturmaktadır.
Araştırmada verilerin toplanmasında tükenmişlik, iş tatmini, duygusal emek ve
işten ayrılma niyeti ölçeklerinden oluşan anket kullanılmıştır. Anket
sonuçlarının analizinde ilgili kriterlerin ağırlıklandırılması Entropi
yöntemiyle yapılmıştır. Daha sonra çok kriterli karar verme tekniklerinden sırasıyla
TOPSIS ve VIKOR yöntemleri kullanılarak akademik personelin duygusal performans
puanları en yüksekten en düşüğe doğru sıralanmıştır. Sonuçta iki farklı
sıralama yöntemi elde edilmiş olup TOPSIS ve VIKOR yöntemlerine göre sıralama
sonuçları karşılaştırılmıştır. İlk ve son sıralarda yer alan kişilerde
benzerlikler gözlemlenmiştir.
El raro oso cantábrico
Authors: Purroy Francisco J.
Published: January 2019

Algo más del centenar de ejemplares, con menos de una veintena en el núcleo oriental (Redes, Picos de Europa, Fuentes Carrionas y La Liébana), hacen del oso pardo cantábrico una especie críticamente amenazada. Enormes dominios vitales, gran movilidad y vida frugal, condicionada por la montanera de robles, hayas y castaños, caracterizan los hábitos del plantígrado. Disparos furtivos, lazos y veneno provocan una mortalidad no natural funesta. Los estudios de la Universidad de León, con el radiomarcaje de Salsero en Riaño, desvelaron aspectos inéditos de historia natural
Yemen and the New Regional Order
Authors: Sławek Jakub
Published: January 2019

This article intends to shed light on the political and security developments in Yemen that ultimately resulted in the Saudi-led military operation in this country. It discusses the political background behind the Yemeni revolu­tion of 2011, its positive outcome in the shape of the results of the National Dialogue Conference and the reasons for the collapse of the efforts to sta­bilize Yemen.
Egypt: Revolution 2011/2025. Dystopia, Utopia, and Political Fiction in Mustafa Al-Husayni’s Novel "2025 An-Nida Al-Akhir"
Authors: Dziekan Marek M.
Published: January 2019

The article discusses the novel 2025. An-Nida al-Akhir [2025. The Last Call] written by a young Egyptian journalist and writer born in 1982 – Mustafa al-Husayni. The novel was published in early 2011, between the fall of Zayn al-Abidin Ibn Ali in Tunisia and of Husni Mubarak in Egypt. It describes a revolution against the regime of Jamal al-Mubarak, son of Husni, spurred by a group of young Egyptians. The story takes place in 2025 and antici­pates the development of the political situation in Egypt and the Middle East between 2011 and 2025 in a utopian/dystopian manner. Alongside Utopia by Ahmad Khalid Tawfik and the poetry of Usama al-Abnubi and Abd ar-Rahman al-Abnudi, al-Husayni’s book is considered to be a forecast of the Arab Spring in Egypt.
Did Egyptian Women Win or Lose by Overthrowing the Regime of Hosni Mubarak?
Authors: Rogowska Blanka
Published: January 2019

Egypt is a place with a long tradition of female participation in revolutions. After years of Mubarak’s despotism, women joined the revolution once again. As a result, they had to deal with the violation of women’s rights. When Morsi was removed, women were again at the top of political topics. The new constitution was described as the most progressive for women. Sisi has been a president for short time but he is already called the presi­dent of women. However women still face problems. They defended them­selves from the Muslim Brotherhood’s rules by supporting Sisi, but did they really win by overthrowing the regime of Mubarak?
Changes in plasma spectral characteristics during the in vitro contact of human venous blood with granulated sorbents
Authors: Burkova N. V. , Kirichuk O. P. , Romanchuk E. V. , Davankov V. A. , Postnov V. N , Kuznetsov S. I.
Published: January 2019

Rationale: During hemosorption procedures, it is important to investigate not only the sorption and activation characteristics of hemocontact agents, but also to assess the eﬀect of sorbents on the parameters of blood homeostasis. The intensity of hemolysis can be judged by the degree of changes in optical density of blood plasma at wavelengths corresponding to the peak absorption of hemoglobin (414, 544 and 577 nm).

Aim: To assess the eﬀect of three granular sorbents (SKT-6A, HPS, Silochrome C-120) contacting human venous blood in vitro on changes in plasma spectral characteristics.

Materials and methods: The blood contact was modeled at bench conditions with the use of donated blood at rotating mode. Blood samples were drawn before the experiment and after 5, 20, 40, and 60 minutes. Spectroscopic assessment was performed in the visible light range (300–700 nm) with UNICO 2802(S) spectrophotometer.

Results: The interaction of the SKT-6A sorbent with blood resulted in a 17.3% decrease in the plasma optical density at a wavelength of 540 nm, compared to baseline, as soon as at 5 minute of the experiment (p < 0.05). The decline in optical density imposed by the blood contact with HPS ranged from 2.6 to 12.1% (p < 0.05) during the observation period. The sorption activity of SKT-6A and HPS prevailed over their lytic properties. On the contrary, the percentage change in the optical density of the Silochrome C-120 sorbent during its blood contact increased from 25.6 to 38.3% (p < 0.05), indicating that this sorbent was inducing hemolysis. The sorbents tested can be arranged as follows according to their ability to induce hemolysis during their contact with blood: HPS < SKT-6A < Silochrome C-120.

Conclusion: The tested SKT-6A and HPS sorbents can be used as blood-contact agents for the low volume hemoperfusion. The HPS agent seems to be the most promising for routine clinical use. The Silochrome C-120 sorbent requires some chemical modifcation to improve its properties of hemocompatibility.
Evaluation of nonlinear dynamics of the cell structure damage as a promising method for personalized cancer diagnostics
Authors: Naimark O. B. , Nikityuk A. S. , Nebogatikov V. O. , Grishko V. V.
Published: January 2019

Background:Modulation interference microscopy is one of the promising technologies for early personalized cancer diagnostics, while it gives the possibility to obtain real-time images of living functioning cells at a nanometer resolution, as well as to assess spatio-temporal changes of their intracellular structures.

Aim:To identify the markers of malignant transformation of cells based on a multiple scale spatio-temporal of the data obtained by lase interferometry duringin situregistration of changes in intracellular structures.

Materials and methods:The study was performed with the breast adenocarcinoma MCF-7 cell line and human kidney epithelial cells HEK 293 provided by the N.N. Blokhin National Medical Research Centre of Oncology (Moscow, Russia). Changes in fluctuation of the living cell phase thickness were measured with a laser modulation interference microscope MIM-340 (PA UOMZ, Russia). The multifractal detrended fluctuation analysis (MF-DFA) was used to assess the results obtained.

Results:By comparison of the scaling exponential spectra and corresponding spectra of the singular fluctuations in the minimal and maximal diameters of the phase pictures of HEK 293 cells and MCF-7 cells, it was shown that the cancer cell dynamics has definite monofractal properties: a linear dependency of the scaling exponentsτfrom the actualqparameter and “dotted” singularity spectrum (the spectral width does not exceed 0.1). The dynamics of healthy cell demonstrated multifractal properties, such as a non-linear dependencyτ(q)and a bell shaped singularity spectrum (the spectral width over 0.1).

Conclusion:We have proposed a new approach to assess the intracellular structural damage during oncogenesis. The signs of monofractality are objective criteria of malignization. The results obtained seems promising as early diagnostic markers of cancer transformation (damage) of cells and determination of tumor cell sensitivity / resistance to anti-tumor agents in an individual patient.
Analysis of Behavioral Factors, Use of Gauze, and House Index with The Incidence of DHF in District Dringu Probolinggo
Authors: Suryanto Hikmawan
Published: January 2019

Dengue Haemorrhagic Fever (DHF) is a contagious disease that is still a public health problem in Indonesia. The purpose of this study was to analyze factors associated with the incidence of dengue fever in the district Dringu Probolinggo. This study was an observational study with cross sectional study design. Sampling was done using cluster random sampling with multistage cluster random sampling method. The results showed that there are four variables related to the incidence of dengue that respondents’ knowledge about the incidence of dengue (p = 0.004), the action of the respondents on the prevention of dengue (p = 0.025), the use of gauze on ventilation (p = 0.035), and the presence of larvae at home respondents (p = 0.044). Knowledge of the respondents have been good, but there are some that are still lacking so it is necessary to increase the respondents’ knowledge about dengue fever. DBD has a good precaution, but there were respondents who still has a moderate value. The use of gauze on the ventilation is still lacking. Lack of use of gauze on ventilation due to ignorance of respondents with benefits gauze. Public Health Center (PHC) and Health Department should improve socialization activities such as outreach to increase public knowledge about the incidence of dengue in order to reduce the number of dengue incidence.
Description Between Cats Exposure with Toxoplasmosis Disease on Cats Owner and Not- Cats Owner in Mulyorejo Subdistrict, Surabaya City
Authors: Agustin Prayuani Dwi , Mukono J
Published: January 2019

Abstract: Toxoplasmosis is an infectious disease caused by  Toxoplasma gondii that transmitted from  animals  to humans. Actually, the symptoms of toxoplasmosis are asymptomatic with non-spesific and  similar to other diseases. Cats  are definite  host  of Toxoplasma gondii.  The  feces from  infected cat  contains million oocysts and  infective  to humans. Detection of toxoplasmosis in human  can be done with a serological test to see the levels of immunoglobulin M (IgM) and immunoglobulin G (IgG) anti-toxoplasmosis. The purpose of this study  was to identification  toxoplasmosis and  describe between exposure from  cats  with toxoplasmosis disease to people who  own and  don’t  own  cats  in Mulyorejo Subdistrict, Surabaya  City. This study  was an descriptive observational research with cross sectional design in two populations. The  subject was  choosen randomly.  This study  was  done to 25 respondents as  cat  owner  and 25 respondents who  weren’t.  Data was collected from questionnaire and  respondent’s blood  sample. Prevalence of toxoplasmosis in cat owner  52% and 48% in not-cat  owner.  Crosstabulation showed that there  were  similar tendency between variables  of feral cats, number of feral cats,  and  presence of cat’s feces to toxoplasmosis disease on cats owner and not-cats  owner in Mulyorejo Subdistrict, Surabaya  City.It is expected that the community is able to notice  the presence of feral cats and cat’s feces around  it to avoid the risk of infection  from Toxoplama  gondii.Keywords: Cats owner,  Not-cats  owner,  Cat, Toxoplasmosis
Mapping And Analysis of Environmental Risk Factors Leptospirosis Incidence Based Geographic Information System (GIS) In Sampang Regency
Authors: Rahim Annisa , Yudhastuti Ririh
Published: January 2019

Abstract: One  of the  zoonosis in Indonesia is leptospirosis. Leptospirosis is caused due  to infection  of bacteria Leptospira. There  were  107 cases and  9 deaths due  to leptospirosis in Sampang. The  incidence of leptospirosis in Sampang was an outbreak. The purpose of this study  was to map the distribution  of leptospirosis cases in Sampang in 2013 and to analyze environmental risk factors of leptospirosis cases (rainfall, altitude, and the presence of flood). This study  was an observational-descriptive study  and used cross-sectional study  design. The unit of analysis  of the study was administrative  regions  based on the districts.  There was patients  of leptospirosis in 4 districts in Sampang regency, there are Sampang district, Camplong district Robatal district and Omben district. The highest incidence of leptospirosis in Sampang regency was occured in Sampang district with rainfall more than 177.6 mm,  altitude less  than 47mdpl, and had experienced flooding.  Mapping  the incidence of leptospirosis showed the distribution  of leptospirosis cases tend to be  concentrated in Sampang district which  had a history of flooding  status.  The conclusion is rainfall, altitude, and presence of flood are risk factors  of leptospirosis. The advice is to improve  surveillance of patients  with leptospirosis particularly during floods,  to do outreach to the community, to perform cross-sector cooperation, to avoid or to reduce the frequency of direct contact with the flood to minimize  transmission of leptospirosis.Keywords: leptospirosis incidence, risk factors,  mapping
Correlation between SO2 with Acute Respiratory Infection in Surabaya City 2013–2015
Authors: Firdaus Aris Putra , Sulistyono Lilis
Published: January 2019

SO2 is an air pollutant and is one of the risk factors of ARI incidence. This research aims to identify the correlation between the levels of SO2 with ARI incidence in Surabaya City 2013–2015. Research on used ecologic study research design and used secondary data. The location selected on the basis of the research areas that have a ﬁ xed ambient air monitoring station SO2 levels that are still active. The location selected on location that has ﬁ xed ambient air monitoring station SO2 gas that is still active. Secondary data on SO2 levels measurement results taken from ﬁ xed ambient air monitoring station in Rungkut and Jambangan. While the ARI incidence secondary data taken at Puskesmas in Kecamatan Rungkut and Puskesmas in Jambangan. Air quality in the Surabaya City is still classiﬁ ed as good on level of SO2 (< 80 μg/m3). The ARI incidence research in two locations during the 2013-2015 has decreased. There is a correlation between levels of SO2 with the ARI incidence, both in Rungkut district (correlation coefﬁ cient = 0.421, p = 0.036) and Jambangan district (correlation coefﬁ cient =-0.450, p = 0.024). SO2 levels are not the primary cause of ARI incidence. The ARI incidence can occur because other factors which are not examined namely indoor air pollution. Need for further research on correlation levels of SO2 in the outdoors and indoors with ARI incidence.