bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Optogenetics to Dissect the Neural Circuits Underlying OCD and Related Disorders
Authors: Piantadosi Sean C. , Ahmari Susanne E.
Published: July 2015

Opinion Statement

Clinical and preclinical studies have uncovered substantial evidence that dysfunction in cortico-striatal-thalamo-cortical (CSTC) loops central to the selection of action strategies may underlie obsessive compulsive disorder (OCD) symptoms. In human OCD, data suggest that the balance between selections of habitual versus goal-directed action strategies is disrupted, with concomitant hyperactivation of CSTC regions associated with these strategies. Preclinical lesion and inactivation studies of homologous CSTC regions in rodents have shed light on how sub-regions of the frontal cortex and striatum can have dissociable effects on the exhibition of goal-directed or habitual behavior. However, these traditional methods lack the precision necessary to dissect the exact projections and cell types underlying these behaviors. It is essential to uncover this information to begin to determine how disruption in these circuits may lead to disease pathology. Here, we summarize several recent studies that utilize optogenetics, a technique that allows stimulation or inhibition of specific neural projections and cell types using light, to further understand the contribution of CSTC activity to both action selection and the OCD-relevant behavior of perseverative grooming. Based on these experiments and findings in human OCD patients, we argue that OCD symptoms may not only be associated with an enhancement of habitual behavior, but also with aberrant recruitment of goal-directed neural circuits. We also discuss the current status of translating optogenetic technology to primates, as well as how findings in rodents may help inform treatment of patients suffering from OCD and related disorders.
Binding of PDZ domains to the carboxy terminus of inducible nitric oxide synthase boosts electron transfer and NO synthesis
Authors: Aicart-Ramos Clara , Rodríguez-Crespo Ignacio
Published: July 2015

iNOS lacks any phosphorylatable residue at its C‐terminus despite displaying a 25‐residue extension known to block electron transfer and activity. We report that C‐terminal deletions of iNOS increased the cytochrome c reduction rate. Moreover, the interaction of the iNOS C‐terminus with the PDZ domains of EBP50 or CAP70 resulted not only in augmented reductase activity and greater NO synthesis but also anticipated the formation of the air‐stable semiquinone generated after NADPH addition. Hence, the C‐terminus of iNOS regulates the activity of the enzyme, albeit, unlike nNOS and eNOS, displacement of the autoinhibitory element occurs upon binding to proteins with PDZ domains.
The route to protein aggregate superstructures: Particulates and amyloid‐like spherulites
Authors: Vetri Valeria , Foderà Vito
Published: July 2015

Depending on external conditions, native proteins may change their structure and undergo different association routes leading to a large scale polymorphism of the aggregates. This feature has been widely observed but is not fully understood yet. This review focuses on morphologies, physico‐chemical properties and mechanisms of formation of amyloid structures and protein superstructures. In particular, the main focus will be on protein particulates and amyloid‐like spherulites, briefly summarizing possible experimental methods of analysis. Moreover, we will highlight the role of protein conformational changes and dominant forces in driving association together with their connection with the final aggregate structure. Eventually, we will discuss future perspectives in this field and we will comment what is, in our opinion, urgently needed.
EPISTEMIC SOLIDARITY AS A POLITICAL STRATEGY
Authors: Goodin Robert E. , Spiekermann Kai
Published: July 2015

Solidarity is supposed to facilitate collective action. We argue that it can also help overcome false consciousness. Groups practice ‘epistemic solidarity’ if they pool information about what is in their true interest and how to vote accordingly. The more numerous ‘Masses’ can in this way overcome the ‘Elites,’ but only if they are minimally confident with whom they share the same interests and only if they are (perhaps only just) better-than-random in voting for the alternative that promotes their interests. Being more cohesive and more competent than the Masses, the Elites can employ the same strategy perhaps all the more effectively. But so long as the Masses practice epistemic solidarity they will almost always win, whether or not the Elites do. By enriching the traditional framework of the Condorcet Jury Theorem with group-specific standards of correctness, we investigate how groups can organize to support the alternatives truly in their interests.
SIMPLE GROUPS STABILIZING POLYNOMIALS
Authors: GARIBALDI SKIP , GURALNICK ROBERT M.
Published: July 2015

We study the problem of determining, for a polynomial function$f$on a vector space$V$, the linear transformations$g$of$V$such that$f\circ g=f$. When$f$is invariant under a simple algebraic group$G$acting irreducibly on$V$, we note that the subgroup of$\text{GL}(V)$stabilizing$f$often has identity component$G$, and we give applications realizing various groups, including the largest exceptional group$E_{8}$, as automorphism groups of polynomials and algebras. We show that, starting with a simple group$G$and an irreducible representation$V$, one can almost always find an$f$whose stabilizer has identity component$G$, and that no such$f$exists in the short list of excluded cases. This relies on our core technical result, the enumeration of inclusions$G<H\leqslant \text{SL}(V)$such that$V/H$has the same dimension as$V/G$. The main results of this paper are new even in the special case where$k$is the complex numbers.
Gender (in) differences in prevalence and incidence of traumatic experiences among orphaned and separated children living in five low- and middle-income countries
Authors: Gray C. L. , Pence B. W. , Ostermann J. , Whetten R. A. , O'Donnell K. , Thielman N. M. , Whetten K.
Published: July 2015

Background.

Approximately 153 million children worldwide are orphaned and vulnerable to potentially traumatic events (PTEs). Gender differences in PTEs in low- and middle-income countries (LMIC) are not well-understood, although support services and prevention programs often primarily involve girls.

Methods.

The Positive Outcomes for Orphans study used a two-stage, cluster-randomized sampling design to identify 2837 orphaned and separated children (OSC) in five LMIC in sub-Saharan Africa and Asia. We examined self-reported prevalence and incidence of several PTE types, including physical and sexual abuse, among 2235 children who were ≥10 years at baseline or follow-up, with a focus on gender comparisons.

Results.

Lifetime prevalence by age 13 of any PTE other than loss of a parent was similar in both boys [91.7% (95% confidence interval (CI) (85.0–95.5)] and girls [90.3% CI (84.2–94.1)] in institutional-based care, and boys [92.0% (CI 89.0–94.2)] and girls [92.9% CI (89.8–95.1)] in family-based care; annual incidence was similarly comparable between institution dwelling boys [23.6% CI (19.1,−29.3)] and girls [23.6% CI (18.6,−30.0)], as well as between family-dwelling boys [30.7% CI (28.0,−33.6)] and girls [29.3% CI (26.8,−32.0)]. Physical and sexual abuse had the highest overall annual incidence of any trauma type for institution-based OSC [12.9% CI (9.6–17.4)] and family-based OSC [19.4% CI (14.5–26.1)], although estimates in each setting were no different between genders.

Conclusion.

Prevalence and annual incidence of PTEs were high among OSC in general, but gender-specific estimates were comparable. Although support services and prevention programs are essential for female OSC, programs for male OSC are equally important.
Mechanistic study of continuous polishing
Authors: Jiao Xiang , Zhu Jianqiang , Fan Quantang , Li Yangshuai
Published: July 2015

To establish the mechanism of surface change in a continuous polishing system, an ideal mathematical model is built based on Winkler’s hypothesis and the Preston equation. The basic features of the model are the change rates in the surface peak–valley (PV) values of the workpiece, conditioning disk and pitch lap, rather than the specific surface shapes. In addition, an equilibrium state exists in the system, indicating that the surface change rates are all zero. Under equilibrium, the surface of the lap could remain flat, and it is insensitive to the surface error of the workpiece. These characteristics lay the theoretical foundations for high-efficiency and high-precision polishing. The methods to obtain an equilibrium state with flat surfaces are then proposed and confirmed experimentally. High-precision surfaces better than$\frac{{\it\lambda}}{10}~({\it\lambda}=632.8~\text{nm})$are consistently produced experimentally.
Hydrodynamic instability experiments with three-dimensional modulations at the National Ignition Facility
Authors: Smalyuk V.A. , Weber S.V. , Casey D.T. , Clark D.S. , Field J.E. , Haan S.W. , Hamza A.V. , Hoover D.E. , Landen O.L. , Nikroo A. , Robey H.F. , Weber C.R.
Published: July 2015

The first hydrodynamic instability growth measurements with three-dimensional (3D) surface-roughness modulations were performed on CH shell spherical implosions at the National Ignition Facility (NIF) [G. H. Miller, E. I. Moses, and C. R. Wuest, Opt. Eng. 43, 2841 (2004)]. The initial capsule outer-surface amplitudes were increased approximately four times, compared with the standard specifications, to increase the signal-to-noise ratio, helping to qualify a technique for measuring small 3D modulations. The instability growth measurements were performed using x-ray through-foil radiography based on time-resolved pinhole imaging. Averaging over 15 similar images significantly increased the signal-to-noise ratio, making possible a comparison with 3D simulations. At a convergence ratio of

${\sim}2.4$

, the measured modulation levels were

${\sim}3$

times larger than those simulated based on the growth of the known imposed initial surface modulations. Several hypotheses are discussed, including increased instability growth due to modulations of the oxygen content in the bulk of the capsule. Future experiments will be focused on measurements with standard 3D ‘native-roughness’ capsules as well as with deliberately imposed oxygen modulations.
Imperfect Corrections or Correct Imperfections? Psychometric Corrections in Meta-Analysis
Authors: Oswald Frederick L. , Ercan Seydahmet , McAbee Samuel T. , Ock Jisoo , Shaw Amy
Published: July 2015

There is understandable concern by LeBreton, Scherer, and James (2014) that psychometric corrections in organizational research are nothing more than a form of statistical hydraulics. Statistical corrections for measurement error variance and range restriction might inappropriately ratchet observed effects upward into regions of practical significance and publication glory—at the expense of highly questionable results.
Irish General Practitioner referrals to psychological therapies
Authors: Cullinan V. , Veale A. , Vitale A.
Published: July 2015

Objective

General Medical Practitioners play a crucial role in the detection and referral of mental health problems in primary care. This study describes the referral patterns of Irish General Practitioners (GPs) to psychological therapies and profiles the range of psychological therapies available.

Method

A 21-item study-specific questionnaire exploring referral processes to psychological therapies was sent to all GPs listed by the Irish College of General Practitioners in one county in Ireland. A 19-item questionnaire exploring details of psychological therapies offered and referral pathways was sent to members of psychological therapy accrediting bodies in the same county.

Results

Of 97 GP respondents (33% response rate), their estimation of the percentage of their patients who have presenting or underlying mental health issues averaged 22%. When asked to indicate which psychological therapies they consider for referrals, psychiatric referrals was the most frequent referral option (94%), followed by Counsellors (69%), Clinical psychologist (60%) and Psychotherapists (30%). GPs indicated they had some or very little knowledge of specific psychological therapies. Of 129 psychological therapists (45% response rate), self-referral and GP referral were their main referral pathways; 80% worked in private practice; highest qualification level was Undergraduate/Higher Diploma (66%), Master Level (39%) and Doctoral Level (5%).

Conclusion

GPs refer patients presenting with mental health problems to psychiatrists with significantly lower percentages referring to other types of psychological therapists. Findings demonstrate that there is a need for greater education and information-sharing between GPs and providers of accredited psychological therapies to increase knowledge on specific therapies and their evidence base.
Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome – a randomised, double-blind, placebo-controlled study
Authors: Hautaniemi Elina J. , Tikkakoski Antti J. , Tahvanainen Anna , Nordhausen Klaus , Kähönen Mika , Mattsson Tiina , Luhtala Satu , Turpeinen Anu M. , Niemelä Onni , Vapaatalo Heikki , Korpela Riitta , Pörsti Ilkka H.
Published: July 2015

We investigated the effects of fermented milk product containing isoleucine–proline–proline, valine–proline–proline and plant sterol esters (Pse) on plasma lipids, blood pressure (BP) and its determinants systemic vascular resistance and cardiac output. In a randomised, double-blind, placebo-controlled study, 104 subjects with the metabolic syndrome (MetS) were allocated to three groups in order to receive fermented milk product containing (1) 5 mg/d lactotripeptides (LTP) and 2 g/d plant sterols; (2) 25 mg/d LTP and 2 g/d plant sterols; (3) placebo for 12 weeks. Plasma lipids and home BP were monitored. Haemodynamics were examined in a laboratory using radial pulse wave analysis and whole-body impedance cardiography in the supine position and during orthostatic challenge. There were no differences between the effects of the two treatments and placebo on the measurements of BP at home or on BP, systemic vascular resistance index and cardiac index in the laboratory, neither in the supine nor in the upright position. The changes in plasma LDL-cholesterol concentration were − 0·1 (95 % CI − 0·3, 0·1 and − 0·3, 0·0) mmol/l in the 5 and 25 mg/d LTP groups, respectively, and +0·1 (95 % CI − 0·1, 0·3) mmol/l during placebo (P= 0·024). Both at baseline and at week 12, the increase in systemic vascular resistance during head-up tilt was lower in the 25 mg/d LTP group than in the 5 mg/d LTP group (P< 0·01), showing persistent differences in cardiovascular regulation between these groups. In subjects with the MetS, intake of LTP and Pse in fermented milk product showed a lipid-lowering effect of borderline significance, while no antihypertensive effect was observed at home or in the laboratory.
Influence of habitual physical activity on gastric emptying in healthy males and relationships with body composition and energy expenditure
Authors: Horner Katy M. , Byrne Nuala M. , Cleghorn Geoffrey J. , King Neil A.
Published: July 2015

Although a number of studies have examined the role of gastric emptying (GE) in obesity, the influences of habitual physical activity level, body composition and energy expenditure (EE) on GE have received very little consideration. In the present study, we compared GE in active and inactive males, and characterised relationships with body composition (fat mass and fat-free mass) and EE. A total of forty-four males (activen22, inactiven22; BMI 21–36 kg/m2; percentage of fat mass 9–42 %) were studied, with GE of a standardised (1676 kJ) pancake meal being assessed by the [13C]octanoic acid breath test, body composition by air displacement plethysmography, RMR by indirect calorimetry, and activity EE (AEE) by accelerometry. The results showed that GE was faster in active compared with inactive males (mean half-time (t1/2): active 157 (sd18) and inactive 179 (sd21) min,P< 0·001). When data from both groups were pooled, GEt1/2was associated with percentage of fat mass (r0·39,P< 0·01) and AEE (r− 0·46,P< 0·01). After controlling for habitual physical activity status, the association between AEE and GE remained, but not that for percentage of fat mass and GE. BMI and RMR were not associated with GE. In summary, faster GE is considered to be a marker of a habitually active lifestyle in males, and is associated with a higher AEE level and a lower percentage of fat mass. The possibility that GE contributes to a gross physiological regulation (or dysregulation) of food intake with physical activity level deserves further investigation.
Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes
Authors: Breen Cathy , Ryan Miriam , Gibney Michael J. , O'Shea Donal
Published: July 2015

Nutrition knowledge and skills enable individuals with type 2 diabetes (T2DM) to make food choices that optimise metabolic self-management and quality of life. The present study examined the relationship between nutrition knowledge and skills, and nutrient intake in T2DM. A cross-sectional analysis of diabetes-related nutrition knowledge and nutrient intake was conducted in 124 T2DM individuals managed in usual care (64 % male, age 57·4 (sd 5·6) years, BMI 32·5 (sd 5·8) kg/m2), using the Audit of Diabetes Knowledge (ADKnowl) questionnaire and a 4 d food diary. Data on sociodemographic characteristics, food label use and weight management were also collected. The average ADKnowl dietary subscale score was 59·2 (sd 16·4) %. Knowledge deficits relating to the impact of macronutrients/foods on blood glucose and lipids were identified. Lower diabetes-related nutrition knowledge was associated with lower intakes of sugar (10·8 (sd 4·7) v. 13·7 (sd 4·6) % for lower dietary knowledge score v. higher dietary knowledge score, P< 0·001), non-milk sugar (9·1 (sd 4·8) v. 12·1 (sd 4·7) % for lower dietary knowledge score v. higher dietary knowledge score, P< 0·001) and fruit/vegetables (230·8 (sd 175·1) v. 322·8 (sd 179·7) g for lower dietary knowledge score v. higher dietary knowledge score, P< 0·001), and higher dietary glycaemic index (GI) (61·4 (sd 4·5) v. 58·4 (sd 4·6) for lower dietary knowledge score v. higher dietary knowledge score, P< 0·002). The majority of the participants were dissatisfied with their weight. Sugar was the most frequently checked nutrient on food labels (59 %), with only 12·1 % checking foods for their energy content. Significant knowledge and skill deficits, associated with the impact of macronutrients/foods on metabolic parameters and food label use, were found. Lower diabetes-related nutrition knowledge was associated with lower sugar and fruit/vegetable intake and higher dietary GI. Dietary education, integrated throughout the lifespan of T2DM, may improve nutrition knowledge and skills and promote more balanced approaches to dietary self-management of T2DM.
Dietary indicaxanthin from cactus pear (Opuntia ficus-indicaL. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers
Authors: Tesoriere Luisa , Attanzio Alessandro , Allegra Mario , Livrea Maria A.
Published: July 2015

Toxic oxysterols in a hypercholesterolaemia-relevant proportion cause suicidal death of human erythrocytes or eryptosis. This process proceeds through early production of reactive oxygen species (ROS), release of prostaglandin (PGE2) and opening of PGE2-dependent Ca channels, membrane phosphatidylserine (PS) externalisation, and cell shrinkage. The present study was the first to reveal that a bioavailable phytochemical, indicaxanthin (Ind) from cactus pear fruit, in a concentration range (1·0–5·0 μM) consistent with its plasma level after a fruit meal, prevents PS externalisation and cell shrinkage in a dose-dependent manner when incubated with isolated healthy human erythrocytes exposed to an oxysterol mixture for 48 h. Dietary Ind inhibited ROS production, glutathione (GSH) depletion, PGE2 release and Ca2+entry. Ind alone did not modify the erythrocyte redox environment or affect other parameters.Ex vivospiking of normal human blood with the oxysterol mixture for 48 h induced eryptosis, resulting in the production of ROS and decreased levels of GSH, which was prevented by concurrent exposure to 5 μm-Ind. The adherence of eryptotic erythrocytes to the endothelium causes vascular tissue injury. Erythrocytes isolated from blood incubated with the oxysterol mixture plus 5 μm-Ind did not adhere to endothelial cell monolayers. Eryptotic erythrocytes may contribute to thrombotic complications in hypercholesterolaemia. Our findings suggest the positive effects of diets containing Ind on erythrocytes in hypercholesterolaemic subjects.
The middle lower Cambrian (Ovetian)Lunagraulosn. gen. from Spain and the oldest trilobite records
Authors: LIÑÁN ELADIO , GÁMEZ VINTANED JOSÉ ANTONIO , GOZALO RODOLFO
Published: July 2015

The type material ofAgraulos antiquusSdzuy, 1961 from the La Herrería Formation, northern Spain, is revised together with additional material and included in the new genusLunagraulos. The stratigraphical range ofLunagraulos antiquus(Sdzuy, 1961) – occurring below that of the trilobite species of the generaLunolenus,MetadoxidesandDolerolenusin the type locality of Los Barrios de Luna in the province of León, northern Spain – and the accompanying ichnofossil assemblage demonstrate an Ovetian age (lower part of Cambrian Stage 3, currently being discussed by the International Subcommission on Cambrian Stratigraphy) for this species. Moreover, the trilobiteLunagraulos tamamensisn. gen. n. sp. is found in the Tamames Sandstone near the village of La Rinconada in the province of Salamanca, central Spain. The biostratigraphical position of this new taxon and its accompanying ichnoassemblage is also analysed and assigned to the lowermost Ovetian Stage. The genusLunagraulosis therefore the oldest agraulid found in the fossil record. The exceptional presence ofLunagraulosin a marine coarse siliciclastic succession – a facies rather typical for the ichnofossilsCruzianaandRusophycus, some of the oldest signs of trilobite activity – suggests that first trilobite representatives may have inhabited high- to middle-energy, marine environments. This hypothesis may also explain both the taxonomic and biostratigraphic heterogeneity of the first trilobite genera appearing across the world, due to preservation problems in this type of facies. Comparison of theLunagraulos biostratigraphy with other coeval Spanish fossil assemblages allows us to propose its intercontinental correlation with the oldest records of currently known trilobites.
Diagnosis of the strongyloid nematodeStrongyloides venezuelensisin experimentally infected rats
Authors: Marques P.D. , Malta F.M. , Meisel D.M.C.L. , Corral M.A. , Pinho J.R. , Costa-Cruz J.M. , Chieffi P.P. , Gryschek R.C.B. , Paula F.M.
Published: July 2015

Strongyloides venezuelensisis an intestinal nematode of rats, frequently used as a model for studying human and animal strongyloidiasis. In the present study, we evaluated parasitological, serological and molecular methods for the diagnosis of experimentalS. venezuelensisin rats,Rattus norvegicus. Blood and faecal samples were collected and analysed up to 60 days post infection (pi) with adult worm recovery occurring from 5 to 45 days pi. Using an enzyme-linked immunosorbent assay (ELISA), serum levels of IgG antibodies increased up to 28 days pi, thereafter decreasing by day 60 pi. Polymerase chain reaction (PCR) assays detectedS. venezuelensisDNA in faecal samples of rats from 5 to 21 days pi. The present study therefore represents the first step towards improving the diagnosis of experimental strongyloidiasis.
Effect of initial conditions on electron–plasma turbulence: a multiresolution analysis
Authors: Chen S. , Maero G. , Romé M.
Published: July 2015

The transverse dynamics of a pure electron plasma confined in a Penning–Malmberg trap is investigated, taking advantage of two-dimensional particle-in-cell numerical simulations. The evolution of the electron plasma turbulence is studied by means of a wavelet-based multiresolution analysis. In particular, a modified recursive denoising algorithm is developed to separate coherent and incoherent (not necessarily homogeneous) components of the flow. A set of simulations have been carried out changing systematically the radii of an initial annular density distribution of the electrons. The results of the multiresolution analysis indicate that the initial density configuration may have a considerable effect on the evolution of turbulence. Even very small initial density fluctuations can lead to quite different final states, especially in the presence of multiple active diocotron modes characterized by similar growth rates.
Parental history of psychiatric diagnoses and unipolar depression: a Danish National Register-based cohort study
Authors: Musliner K. L. , Trabjerg B. B. , Waltoft B. L. , Laursen T. M. , Mortensen P. B. , Zandi P. P. , Munk-Olsen T.
Published: July 2015

Background

Depression is known to run in families, but the effects of parental history of other psychiatric diagnoses on depression rates are less well studied. Few studies have examined the impact of parental psychopathology on depression rates in older age groups.

Method

We established a population-based cohort including all individuals born in Denmark after 1954 and alive on their 10th birthday (N = 29 76 264). Exposure variables were maternal and paternal history of schizophrenia, bipolar disorder, depression, anxiety or ‘other’ psychiatric diagnoses. Incidence rate ratios (IRRs) were estimated using Poisson regressions.

Results

Parental history of any psychiatric diagnosis increased incidence rates of outpatient (maternal: IRR 1.88, p < 0.0001; paternal: IRR 1.68, p < 0.0001) and inpatient (maternal: IRR 1.99, p < 0.0001; paternal: IRR 1.83, p < 0.0001) depression relative to no parental history. IRRs for parental history of non-affective disorders remained relatively stable across age groups, while IRRs for parental affective disorders (unipolar or bipolar) decreased with age from 2.29–3.96 in the youngest age group to 1.53–1.90 in the oldest group. IRR estimates for all parental diagnoses were similar among individuals aged ⩾41 years (IRR range 1.51–1.90).

Conclusions

Parental history of any psychiatric diagnosis is associated with increased incidence rates of unipolar depression. In younger age groups, parental history of affective diagnoses is more strongly associated with rates of unipolar depression than non-affective diagnoses; however, this distinction disappears after age 40, suggesting that parental psychopathology in general, rather than any one disorder, confers risk for depression in middle life.
The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis
Authors: Carrión R. E. , McLaughlin D. , Auther A. M. , Olsen R. , Correll C. U. , Cornblatt B. A.
Published: July 2015

Background

Although cognitive deficits in patients with schizophrenia are rooted early in development, the impact of psychosis on the course of cognitive functioning remains unclear. In this study a nested case-control design was used to examine the relationship between emerging psychosis and the course of cognition in individuals ascertained as clinical high-risk (CHR) who developed psychosis during the study (CHR + T).

Method

Fifteen CHR + T subjects were administered a neurocognitive battery at baseline and post-psychosis onset (8.04 months, s.d. = 10.26). CHR + T subjects were matched on a case-by-case basis on age, gender, and time to retest with a group of healthy comparison subjects (CNTL, n = 15) and two groups of CHR subjects that did not transition: (1) subjects matched on medication treatment (i.e. antipsychotics and antidepressants) at both baseline and retesting (Meds-matched CHR + NT, n = 15); (2) subjects unmedicated at both assessments (Meds-free CHR + NT, n = 15).

Results

At baseline, CHR + T subjects showed large global neurocognitive and intellectual impairments, along with specific impairments in processing speed, verbal memory, sustained attention, and executive function. These impairments persisted after psychosis onset and did not further deteriorate. In contrast, CHR + NT subjects demonstrated stable mild to no impairments in neurocognitive and intellectual performance, independent of medication treatment.

Conclusions

Cognition appears to be impaired prior to the emergence of psychotic symptoms, with no further deterioration associated with the onset of psychosis. Cognitive deficits represent trait risk markers, as opposed to state markers of disease status and may therefore serve as possible predictors of schizophrenia prior to the onset of the full illness.
Fusion energy using avalanche increased boron reactions for block-ignition by ultrahigh power picosecond laser pulses
Authors: Hora Heinrich , Korn Georg , Giuffrida Lorenzo , Margarone Daniele , Picciotto Antonino , Krasa Josef , Jungwirth Karel , Ullschmied Jiri , Lalousis Paraskevas , Eliezer Shalom , Miley George H. , Moustaizis Stavros , Mourou Gérard
Published: July 2015

Exceptionally high reaction gains of hydrogen protons measured with the boron isotope 11 are compared with other fusion reactions. This is leading to the conclusion that secondary avalanche reactions are happening and confirming the results of high-gain, neutron-free, clean, safe, low-cost, and long-term available energy. The essential basis is the unusual non-thermal block-ignition scheme with picosecond laser pulses of extremely high powers above the petawatt range.
Beat wave excitation of electron plasma wave by coaxial cosh-Gaussian laser beams in collisional plasma
Authors: Singh Arvinder , Gupta Naveen
Published: July 2015

This paper presents a scheme for beat wave excitation of an electron plasma wave (EPW) by cross-focusing of two intense cosh-Gaussian (ChG) laser beams in an under dense collisional plasma. The plasma wave is generated on account of beating of two ChG laser beams of frequencies ω1 and ω2. Starting from Maxwell's equations, coupled differential equations governing the evolution of spot size of laser beams with distance of propagation have been derived by using Moment theory approach in Wentzel–Kramers–Brillouin approximation. The collisional nonlinearity depends not only on the intensity of first laser beam, but also on that of second laser beam. Therefore, dynamics of first laser beam affects that of other and hence cross-focusing of the two laser beams takes place. Numerical simulations have been carried out to investigate the effect of laser as well as plasma parameters on cross-focusing of laser beams and further its effect on power of excited EPW. It has been found that decentered parameters of the two laser beams have significant effect on power of EPW.
Radiation of high-power ultrawideband pulses with elliptical polarization by four-element array of cylindrical helical antennas
Authors: Andreev Yu.A. , Efremov A.M. , Koshelev V.I. , Kovalchuk B.M. , Plisko V.V. , Sukhushin K.N. , Zorkaltseva M.Yu.
Published: July 2015

A high-power source of ultrawideband radiation with elliptical polarization of the field has been created. The source includes a monopolar pulse generator, a bipolar pulse former, a wave transformer with the power divider, and a four-element array of cylindrical helical antennas. The array was excited by bipolar pulses of the length 1 ns and amplitude 225 kV. In the experiments, the pulses of the elliptically polarized radiation with the effective potential of 440 kV and high stability at a pulse repetition rate of 100 Hz were obtained.
EVIDENCE REQUIREMENTS FOR REIMBURSEMENT OF PHARMACEUTICALS ACROSS EUROPE
Authors: Oyebode Oyinlola , Garrett Zoe , George Elizabeth , Cangini Agnese , Muscolo Luisa Anna Adele , Warren Simone , Nemeth Bertalan , Földesi Csenge , Heislerová Marcela , Gajdošová Eva
Published: July 2015

Objectives: The objective of this study was to compare evidence requirements for health technology assessment of pharmaceuticals by national agencies across Europe responsible for reimbursement decisions focusing specifically on relative effectiveness assessment.

Methods: Evidence requirements from thirty-three European countries were requested and twenty-nine national agencies provided documents to review. Data were extracted from national documents (manufacturer's submission templates and associated guidance) into a purpose-made framework with categories covering information about the health condition, the technology, clinical effectiveness and safety.

Results: The level of detail in the required evidence varies considerably across countries. Some countries include specific questions while others request information under general headings. Some countries include all information in a single document, which may or may not include guidance on how to complete the template. Others have specific guidance documents or methods and process manuals that help with the completion of the submission templates. Despite differences in quantity and detail, the content of the evidence requirements is broadly similar. All countries ask for information on the health technology, target disease, and clinical effectiveness and safety. However, one country only requests clinical effectiveness information as part of cost-effectiveness analyses. We found twenty-six evidence requirements for which generic answers may apply across borders and nineteen in which countries requested nationally specific information.

Conclusions: This work suggests that it would be possible to put together a minimum set of evidence requirements for HTA to support reimbursement decisions across Europe which could facilitate collaboration between jurisdictions.
Increase in paratyphoid fever cases in Japanese travellers returning from Cambodia in 2013
Authors: SAITOH T. , MORITA M. , SHIMADA T. , IZUMIYA H. , KANAYAMA A. , OISHI K. , OHNISHI M. , SUNAGAWA T.
Published: July 2015

In 2013, an unusual increase of paratyphoid fever cases in travellers returning from Cambodia was reported in Japan. From December 2012 to September 2013, 18 cases ofSalmonellaParatyphi A infection were identified. Microbiological analyses revealed that most isolates had the same clonal identity, although the epidemiological link between these cases remains unclear. It was inferred that the outbreak was caused by a common and persistent source in Cambodia that was likely to have continued during 2014. The information of surveillance and laboratory data from cases arising in travellers from countries with limited surveillance systems should be timely shared with the country of origin.
New-onset cardiac rhabdomyoma beyond infancy in a patient with tuberous sclerosis complex
Authors: Thatte Nikhil M. , Guleserian Kristine J. , Veeram Reddy Surendranath R.
Published: July 2015

Cardiac rhabdomyomas in patients with tuberous sclerosis complex are usually detected antenatally or during infancy, with subsequent stabilisation or spontaneous regression. Development of a new cardiac rhabdomyoma beyond infancy is very rare. We report a male child who needed resection of a large rhabdomyoma in neonatal life, and then developed a new-onset rhabdomyoma at 2 years of age in a different location, needing another resection. Routine surveillance for cardiac rhabdomyomas in asymptomatic patients with tuberous sclerosis is essential.
Folate and folic acid in the periconceptional period: recommendations from official health organizations in thirty-six countries worldwide and WHO
Authors: Gomes Sandra , Lopes Carla , Pinto Elisabete
Published: July 2015

Objective

To summarize the recommendations on folate intake and folic acid supplementation and fortification in the periconceptional period, aimed at prevention of neural tube defects (NTD), provided by official health organizations in different countries worldwide and WHO.

Design

Information on recommendations for folate and folic acid intake in the periconceptional period was gathered from the websites of official national health organizations of several countries worldwide and from the WHO website.

Setting

WHO, selected developed countries and emerging economies, totalling thirty-six countries worldwide (some European, BRICS, G8, Asian Tiger/Asian Dragon and Australia).

Results

Recommendations differ between countries, although the majority (69·4 %) recommend a healthy diet plus a folic acid supplement of 400 µg/d from preconception (4–12 weeks) until the end of the first trimester of pregnancy (8–12 weeks). The same recommendation is issued by the WHO. Dosages for women at high risk of NTD are up to 4–5 mg/d (for 41·7 % of studied countries). The recommended intake for folate is in the range of 300–400 µg/d for women of childbearing age and 500–600 µg/d for pregnant women in different countries and WHO. Five countries emphasize the importance of a healthy diet rendering supplementation needless. By contrast, five others advise a healthy diet and supplementation plus mandatory fortification. Only one mentions the importance of ensuring an adequate folate status and refers to checking with a health-care provider on the need for supplements.

Conclusions

Different recommendations regarding folate and folic acid, seeking NTD prevention, are available worldwide; however, most countries and WHO focus on a healthy diet and folic acid supplementation of 400 µg/d periconceptionally.
An integrated approach to identifying and characterising resilient urban food systems to promote population health in a changing climate
Authors: James Sarah W , Friel Sharon
Published: July 2015

Objective

To determine key points of intervention in urban food systems to improve the climate resilience, equity and healthfulness of the whole system.

Design

The paper brings together evidence from a 3-year, Australia-based mixed-methods research project focused on climate change adaptation, cities, food systems and health. In an integrated analysis of the three research domains – encompassing the production, distribution and consumption sectors of the food chain – the paper examines the efficacy of various food subsystems (industrial, alternative commercial and civic) in achieving climate resilience and good nutrition.

Setting

Greater Western Sydney, Australia.

Subjects

Primary producers, retailers and consumers in Western Sydney.

Results

This overarching analysis of the tripartite study found that: (i) industrial food production systems can be more environmentally sustainable than alternative systems, indicating the importance of multiple food subsystems for food security; (ii) a variety of food distributors stocking healthy and sustainable items is required to ensure that these items are accessible, affordable and available to all; and (iii) it is not enough that healthy and sustainable foods are produced or sold, consumers must also want to consume them. In summary, a resilient urban food system requires that healthy and sustainable food items are produced, that consumers can attain them and that they actually wish to purchase them.

Conclusions

This capstone paper found that the interconnected nature of the different sectors in the food system means that to improve environmental sustainability, equity and population health outcomes, action should focus on the system as a whole and not just on any one sector.
Fruit-related terms and images on food packages and advertisements affect children’s perceptions of foods’ fruit content
Authors: Heller Rebecca , Martin-Biggers Jennifer , Berhaupt-Glickstein Amanda , Quick Virginia , Byrd-Bredbenner Carol
Published: July 2015

Objective

To determine whether food label information and advertisements for foods containing no fruit cause children to have a false impression of the foods’ fruit content.

Design

In the food label condition, a trained researcher showed each child sixteen different food label photographs depicting front-of-food label packages that varied with regard to fruit content (i.e. real fruitv. sham fruit) and label elements. In the food advertisement condition, children viewed sixteen, 30 s television food advertisements with similar fruit content and label elements as in the food label condition. After viewing each food label and advertisement, children responded to the question ‘Did they use fruit to make this?’ with responses of yes, no or don’t know.

Setting

Schools, day-care centres, after-school programmes and other community groups.

Subjects

Children aged 4–7 years.

Results

In the food label condition,χ2analysis of within fruit content variation differences indicated children (n58; mean age 4·2 years) were significantly more accurate in identifying real fruit foods as the label’s informational load increased and were least accurate when neither a fruit name nor an image was on the label. Children (n49; mean age 5·4 years) in the food advertisement condition were more likely to identify real fruit foods when advertisements had fruit images compared with when no image was included, while fruit images in advertisements for sham fruit foods significantly reduced accuracy of responses.

Conclusions

Findings suggest that labels and advertisements for sham fruit foods mislead children with regard to the food’s real fruit content.
Community-based educational intervention improved the diversity of complementary diets in western Kenya: results from a randomized controlled trial
Authors: Waswa Lydiah M , Jordan Irmgard , Herrmann Johannes , Krawinkel Michael B , Keding Gudrun B
Published: July 2015

Objective

Lack of diversity is a major factor contributing to inadequate nutrient intakes among children during the complementary feeding period in many rural areas in developing countries. This has been attributed to inadequate feeding practices and nutrition knowledge among their caregivers. The aim of the present study was to assess the effect of an educational intervention on children’s dietary diversity and nutrition knowledge of caregivers.

Design

Cluster randomization was applied and twenty matched village pairs were randomly assigned to the intervention or control group. The nutrition education intervention consisted of four sessions comprising of group trainings and cooking demonstrations that were conducted over a period of 5 months.

Setting

Households in rural communities in Bondo and Teso South sub-counties, western Kenya.

Subjects

Caregivers with children aged 6–17 months receiving nutrition education.

Results

The children’s dietary diversity scores (CDDS) and nutrition knowledge scores of the caregivers improved significantly in the intervention group at endline. The treatment effect on CDDS was positive and significant (P=0·001). The CDDS rate of the children in the intervention group was 27 % larger than it would have been without the treatment effect. The intervention also had a significant effect on the caregivers’ nutrition knowledge scores (incidence rate ratio=2·05;P<0·001). However, the nutrition knowledge of the caregivers did not have a significant effect on CDDS (P=0·731).

Conclusions

The nutrition education intervention led to improvements in children’s dietary diversity and nutrition knowledge of the caregivers.
Nutrient profile of 23 596 packaged supermarket foods and non-alcoholic beverages in Australia and New Zealand
Authors: Ni Mhurchu Cliona , Brown Ryan , Jiang Yannan , Eyles Helen , Dunford Elizabeth , Neal Bruce
Published: July 2015

Objective

To compare the nutrient profile of packaged supermarket food products available in Australia and New Zealand. Eligibility to carry health claims and relationship between nutrient profile score and nutritional content were also evaluated.

Design

Nutritional composition data were collected in six major Australian and New Zealand supermarkets in 2012. Mean Food Standards Australia New Zealand Nutrient Profiling Scoring Criterion (NPSC) scores were calculated and the proportion of products eligible to display health claims was estimated. Regression analyses quantified associations between NPSC scores and energy density, saturated fat, sugar and sodium contents.

Results

NPSC scores were derived for 23 596 packaged food products (mean score 7·0, range −17 to 53). Scores were lower (better nutrient profile) for foods in Australia compared with New Zealand (mean 6·6 v. 7·8). Overall, 45 % of foods were eligible to carry health claims based on NPSC thresholds: 47 % in Australia and 41 % in New Zealand. However, less than one-third of dairy (32 %), meat and meat products (28 %) and bread and bakery products (27·5 %) were eligible to carry health claims. Conversely, >75 % of convenience food products were eligible to carry health claims (82·5 %). Each two-unit higher NPSC score was associated with higher energy density (78 kJ/100 g), saturated fat (0·95 g/100 g), total sugar (1·5 g/100 g) and sodium (66 mg/100 g; all P values<0·001).

Conclusions

Fewer than half of all packaged foods available in Australia and New Zealand in 2012 met nutritional criteria to carry health claims. The few healthy choices available in key staple food categories is a concern. Improvements in nutritional quality of foods through product reformulation have significant potential to improve population diets.
Fish and fish-liver oil consumption in adolescence and midlife and risk of CHD in older women
Authors: Haraldsdottir Alfheidur , Torfadottir Johanna E , Valdimarsdottir Unnur A , Aspelund Thor , Harris Tamara B , Launer Lenore J , Gudnason Vilmundur , Steingrimsdottir Laufey
Published: July 2015

Objective

To study the association of fish and fish-liver oil consumption across the lifespan with CHD later in life among Icelandic women, with special emphasis on the effects of consumption in adolescence.

Design

Prevalence association study. Logistic regression was used to estimate odds ratios and 95 % confidence intervals of CHD according to fish or fish-liver oil exposure. Models were adjusted for age, education, concurrent diet and other known risk factors.

Setting

The study was nested within the AGES-Reykjavik Study, conducted in Reykjavik, Iceland.

Subjects

Participants were 3326 women aged 66–96 years, with available information on CHD status at entry to the study and information on fish and fish-liver oil consumption during midlife and adolescence. Dietary habits were assessed retrospectively using a validated FFQ.

Results

CHD was identified in 234 (7·9 %) women. Compared with women with no intake of fish-liver oil in adolescence or midlife, women who consumed fish-liver oil at least three times weekly in adolescence or in midlife had a decreased risk of CHD (OR=0·62; 95 % CI 0·45, 0·85 and OR=0·68; 95 % CI 0·50, 0·94, respectively). No associations were observed between fish intake (>2 portions/week v. ≤2 portions/week) in adolescence or midlife and CHD in this population with high fish intake.

Conclusions

Fish-liver oil consumption, from early life, may reduce the risk of CHD in older women. Lifelong nutrition may be of importance in the prevention of CHD in older women.