bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes Using High KDPI Kidneys in Recipients Over 65 y of Age
Authors: Goussous Naeem , De Leon Fransia , Alghannam Karima , Howard Brian C. , Than Peter A. , Wang Aileen X , Sageshima Junichiro , Perez Richard V.
Published: November 2024

Background.

Kidney transplantation has been shown to improve life expectancy when compared with remaining on dialysis. However, there is an ever-expanding shortage of available organs for transplantation. The use of high kidney donor profile index (KDPI; >85) kidneys is 1 strategy to address this shortage. The current study aims to evaluate the advantage of accepting a high KDPI versus a low KDPI kidney (KDPI ≤85) in patients 65 y or older.

Methods.

A single-center retrospective review of all patients, ages 65 y or older, who underwent deceased donor kidney transplantation between 2010 and 2020 was performed. Outcomes and wait times of recipients undergoing low KDPI (KDPI ≤85) versus high KDPI (KDPI >85) kidney transplantation were compared. Significance was defined as P < 0.05.

Results.

Four hundred ninety-two patients were identified; 317 (64.4%) were men with a median age at transplantation of 69 y. Four hundred five patients received low KDPI kidneys, whereas the remaining received high KDPI grafts. High KDPI kidneys were procured from older donors (60 versus 47, P < 0.001) and had shorter cold ischemic time (25.0 versus 28.3 h, P = 0.01) compared with low KDPI kidneys. There was no significant difference in graft and patient survival between low and high KDPI recipients, with 85.1% and 86.2% grafts functioning at a follow-up of 4.85 (2.9–7.0) y, respectively. Pretransplant wait time was significantly shorter in the high KDPI group (2.7 [1.8–4.1] versus 3.5 [2.3–4.8] y; P = 0.004).

Conclusions.

In patients 65 y or older undergoing deceased donor kidney transplantation, high KDPI kidneys may offer shorter pretransplant waiting times without compromising graft or patient survival.
Quality characteristics of ginger and ginger pomace powder by
freeze-drying
Authors: Jo Yun-Jeong
Published: November 2024

We investigated the quality characteristics of ginger and the discarded ginger
pomace after juicing, including general components, functional components, and
antioxidant activity, to provide basic data on the possibility and usability of
using them as food materials. When ginger was hot-air drying and freeze-drying,
the total polyphenol content was 103.88 mg/100 mL and 108.68 mg/100 mL,
respectively, which was higher than that of ginger pomace. DPPH radical
scavenging activity was 70.84% and 77.88% for freeze-drying ginger and ginger
pomace, respectively, and ABTS radical scavenging activity was high at 95.5%
when ginger pomace was freeze-dried. The gingerol content was 680.90 mg% and
708.03 mg% in hot-air drying and freeze-drying ginger, respectively. In the case
of ginger pomace, it was 914.47 mg% and 964.33 mg%, indicating that the
functional components were higher in ginger pomace. Based on these results, it
was concluded that when ginger and ginger pomace were processed by hot-air
drying and freeze-drying, not only ginger but also ginger pomace showed overall
functional component content and antioxidant activity. Thus it is judged that it
can be utilized in various ways as a food material.
HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma
Authors: Yuan Juan , Maitra Subhamita , Antoniou Eirini , Zhu Jiacheng , Li Wenyu , Demirel Ilknur Safak , Toskas Kostantinos , Martinez Iria Laura , Ozcimen Lacin , Lindehell Henrik , Kogner Per , Bedoya-Reina Oscar C. , Schlisio Susanne , Holmberg Johan
Published: November 2024

The role of HIF2α, encoded byEPAS1, in neuroblastoma remains controversial. Here we demonstrate that induction of high levels of HIF2α in MYCN-amplified neuroblastoma cells results in a rapid and profound reduction of the oncoprotein MYCN. This is followed by an upregulation of genes characteristic of noradrenergic cells in the adrenal medulla. Additionally, upon induction of HIF2α, the proliferation rate drops substantially, and cells develop elongated neurite-like protrusions, indicative of differentiation.In vivoHIF2α induction in established xenografts significantly attenuates tumour growth. Notably, analysis of sequenced neuroblastoma patient samples, revealed a negative correlation betweenEPAS1andMYCNexpression and a strong positive correlation betweenEPAS1expression, high expression levels of noradrenergic markers, and improved patient outcome. This was paralleled by analysis of human adrenal medulla datasets whereinEPAS1expression was prominent in populations with high expression levels of genes characteristic of noradrenergic chromaffin cells. Our findings show that high levels of HIF2α in neuroblastoma, leads to drastically reduced MYCN protein levels, cell cycle exit, and noradrenergic cell differentiation. Taken together, our results challenge the dogma that HIF2α acts as an oncogene in neuroblastoma and rather suggest that HIF2α has potential tumour suppressor capacity in this particular disease.

Significance statement

HIF2α has been proposed as a neuroblastoma oncogene and a tractable target for clinical intervention, this has been questioned by several studies. Thus, it is necessary to move beyond correlative studies and better determine the function of HIF2α in neuroblastoma. Our study shows that induced expression of HIF2α inMYCN-amplified neuroblastoma substantially reduces MYCN protein levels and attenuates proliferation while it induces several features of noradrenergic differentiation and impedes xenograft tumour growth. Together with bioinformatic analysis of sequenced neuroblastoma patient samples and the developing human adrenal medulla, this couples HIF2α to low-risk neuroblastoma with a substantially better patient outcome. Thus, in neuroblastoma HIF2α exhibit tumour suppressor capacity rather than oncogenic capacity.
Three STEPs forward: A trio of unexpected structures of PTPN5
Authors: Guerrero Liliana , Ebrahim Ali , Riley Blake T. , Kim Sean H. , Bishop Anthony C. , Wu Jiaqian , Han Ye Na , Tautz Lutz , Keedy Daniel A.
Published: November 2024

Protein tyrosine phosphatases (PTPs) play pivotal roles in myriad cellular processes by counteracting protein tyrosine kinases. Striatal-enriched protein tyrosine phosphatase (STEP, PTPN5) regulates synaptic function and neuronal plasticity in the brain and is a therapeutic target for several neurological disorders. Here, we present three new crystal structures of STEP, each with unexpected features. These include high-resolution conformational heterogeneity at multiple sites, and a highly coordinated citrate molecule in the active site, a previously unseen conformational change at an allosteric site, an intramolecular disulfide bond that was characterized biochemically but had never been visualized structurally, and two serendipitous covalent ligand binding events at surface-exposed cysteines that are nearly or entirely unique to STEP among human PTPs. Together, our results offer new views of the conformational landscape of STEP that may inform structure-based design of allosteric small molecules to specifically inhibit this biomedically important enzyme.
Exploring the Hypothetical Role ofBacteroidesSpecies in Depression Progression: Insights from Metagenomic Analysis
Authors: Li Zihua , Sun Jingxi , Yang Jinlong , Han Panpan , Min Liping , Cheng Yongkang , Zou Yuanqiang , Liu Zhuhua
Published: November 2024

Depression, a psychiatric disorder with significant morbidity and mortality, has a complex etiology. Recent advances in microbiome research have highlighted the potential role of gut microbiota in depression pathogenesis. This study utilized shotgun metagenomic sequencing to compare the fecal microbiota of 28 depression patients and 26 healthy individuals. Significant differences in gut microbiota composition were observed between the two groups. We generated 350 non-redundant high-quality metagenome-assembled Genomes (MAGs) by binning and conducted comparisons between the depression and control groups. Notably, we found that the MAGs enriched in people with depression mostly belonged toBactendicating a close link betweenBacteroidesabundance and the development of depression, suggesting thatBacteroidesmight be a potential culprit for deroides, ipression. In the depression group, we found that the module of nitric oxide synthesis was remarkably enriched, and allBacteroidesMAGs were annotated to nitric oxide synthase, suggesting that increased levels of Bacteroides may contribute to elevated nitric oxide synthesis. Specifically, the mean relative abundance about the genomes ofBacteroides xylanisolvens,Bacteroides caccae,Bacteroides fragilis,Bacteroides stercorisandBacteroides ovatusshowed strong discriminatory power in distinguishing depressed patients from healthy individuals (AUC=0.834). This research shed light on the potential role of gut microbiota in depression and highlights specific metabolic pathways and microbial markers for further investigation.

Improtance

This research highlighted significant differences in the composition and function of gut microbiota between individuals with depression and healthy individuals, particularly the enrichment ofBacteroidesMAGs in depression patients. The upregulation of the nitric oxide synthesis pathway associated with these MAGs belong toBacteroidesin the gut of depression patients had also been observed. The mean relative abundance of a specific set ofBacteroidesMAGs had been identified, which could accurately classify individuals with depression from healthy individuals (AUC=0.834). Our results suggest the importance of exploring microbial markers as potential diagnostic and therapeutic targets in managing depression.
A process-based model simulating the life cycle ofCulex pipiness.s./Cx. torrentiumin Germany
Authors: Rauhöft L. , Duve P. , Martins Afonso S.M. , Jöst H. , Şuleşco T. , Sauer F.G. , Lühken R.
Published: November 2024

Mosquitoes are well known for their ability to transmit pathogens, including various arthropod-borne viruses (arboviruses) that are of veterinary and medical interest. The threat of (re-)emerging arboviruses in Europe is increasing due to globalization and climate warming. This also applies to temperate regions, where the transmission of viruses is becoming possible due to an increase of the ambient temperature, i.e. shortening of the extrinsic incubation period.Culex pipienss.s./Culex torrentiumare the primary vectors of Usutu virus and West Nile virus in Europe and is commonly found in and around human settlements. The prediction of spatial-temporal abundance allows for the early assessment of arbovirus transmission risk and the organization of intervention methods, such as vector control. A process-based model was developed to predict the spatial-temporal occurrence ofCx. pipienss.s./Culex torrentiumin Germany. The model output is driven by local rainfall and temperature data provided by the European re-analysis and observations for monitoring (E-OBS) data set. Evaluated with field data from over 123 sampling sites, the model is capable of pinpointing the peak in abundance. The mean offset of the simulated and observed peak is −3.16 (CI95=−9.73-3.4) and does not significantly differ from zero (t(145)=−0.95, p-value=0.34). One third of the sampling sites showed a significant positive Pearson correlation between simulated and observed mosquito abundance and there is an overall significant linear relationship (LM: adj. R2=0.24, F(1, 3434). The model is also capable of predicting population dynamics for entire Europe, as tested for Moldavia, Ireland, Sweden and Spain. This process-based model can be used to simulate vector control measurements or the impact of increasing temperatures in cause of climate warming.
Age-associated modulation of TREM1/2- expressing macrophages promotes melanoma progression and metastasis
Authors: Scortegagna Marzia , Murad Rabi , Bina Parinaz , Feng Yongmei , Porritt Rebecca , Terskikh Alexey , Tian Xiao , Adams Peter D. , Vuori Kristiina , Ronai Ze’ev A.
Published: November 2024

Aging is a known risk factor for melanoma, yet mechanisms underlying melanoma progression and metastasis in older populations remain largely unexplored. Among the current knowledge gaps is how aging alters phenotypes of cells in the melanoma microenvironment. Here we demonstrate that age enriches the immunosuppressor tumor microenvironment, which is linked to phenotypes associated with melanoma metastasis. Among cellular populations enriched by aging were macrophages with a tolerogenic phenotype expressing TREM2 and dysfunctional CD8-positive cells with an exhausted phenotype, while macrophages with profibrotic phenotype expressing TREM1 were depleted. Notably, TREM1 inhibition decreased melanoma growth in young but not old mice, whereas TREM2 inhibition prevented lung metastasis in aged mice. These data identify novel targets associated with melanoma metastasis and may guide aged-dependent immunotherapies.
Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography
Authors: Brück Jürgen , Schauenburg Dominik , Kuan Seah Ling , Göttert Simeon , Klasen Benedikt , Frommberger Veronika , Jalal Kazem Ebadi , Boui Nabil , Kwiatkowski Aaron , Schake Lisa , Bopp Tobias , Bohn Tozka , Weil Tanja , Schreckenberger Mathias , Matthias Miederer
Published: November 2024

Slight changes in the pH value of the tumor microenvironment (TME) have crucial effects on host defense, metastatic behavior, immune regulation and cellular metabolism. Due to the high metabolic activity and insufficient perfusion of tumors, acidic metabolites often accumulate in tumors and can influence the pH of the TME. Several studies have shown that the acidity of the interstitial space and the relatively stable intracellular pH can influence the functions of cancer and stromal cells and their interaction with the extracellular matrix.

We describe radiopharmaceutical probes for positron emission tomography (PET) that exploits the increasingly used concept of pH-dependent intratumorally cleavage of PET-tracer to release functional moieties. The radiopharmaceuticals are based on [18F]FDG, a PET tracer, routinely used, and substituents that are pH-dependently cleaved. Utilizing preclinical models, we were able to visualize small pH differences in the acidic TME of different tumors with [18F]FDG-4-methoxybenzylamine ([18F]FDG-4MBA).In vivostudies were in line with invitro resultsand showed that the hemiaminal bond between FDG and a substitute is cleaved at slightly acidic pH and leads to pH dependent radiotracer uptake.In vivoneutralization of the acidic extracellular tumor pH by sodium bicarbonate treatment prevents pH-dependent cleavage of [18F]FDG-4MBA and a resulting decrease of uptake. The determination of pH differences in acidic TME may serve as a novel marker for various questions such as regulation of the response to immunotherapies. Notably, even small pH differences in the acidic TME of different tumors, in the samein vivomodel, could be visualized. This is the first preclinical study to show that it is possible to visualize small pH differences in the TME of different tumors in the same mouse using hemiaminal bound [18F]FDG. Due to the facile tracer synthesis and application, this system could be well suited for translation into clinical studies to develop new strategies of pH regulation to improve the efficacy of immunotherapy in cancer patients.

graphical abstract
Searching for Jouvence SnoRNA in the Horse Genome
Authors: Peffers Mandy , van den Akker Guus , Clarke Emily , Fang Yongxiang
Published: November 2024

In humans, various pathologies have been associated with snoRNAs. Others have shown that the expression of a non-canonical snoRNA Jouvence is involved in lifespan determination in relation to gut homeostasis. As snoRNAs are evolutionary conserved, both structurally and functionally, a jouvence orthologue has been identified in humans. This study aimed to locate the Jouvence snoRNA in the horse genome. Using our previous snoRNA data in ageing equine cartilage along with equine genome data we identified a putative equine Jouvence snoRNA gene. ECABCGRLG0000000730 was the primary candidate horse Jouvence snoRNA. The expression of equine Jouvence snoRNA was increased in ageing equine cartilage.
Pseudo-easy-axis anisotropy in antiferromagnetic
S=1
diamond-lattice systems
Authors: Vaidya S. , Hernández-Melián A. , Tidey J. P. , Curley S. P. M. , Sharma S. , Manuel P. , Wang C. , Hannaford G. L. , Blundell S. J. , Manson Z. E. , Manson J. L. , Singleton J. , Lancaster T. , Johnson R. D. , Goddard P. A.
Published: November 2024

We investigate the magnetic properties of S=1 antiferromagnetic diamond-lattice, NiX2(pyrimidine)2 (X=Cl, Br), hosting a single-ion anisotropy (SIA) orientation which alternates between neighboring sites. Through neutron diffraction measurements of the X=Cl compound, the ordered state spins are found to align collinearly along a pseudo-easy axis, a unique direction created by the intersection of two easy planes. Similarities in the magnetization, exhibiting spin-flop transitions, and the magnetic susceptibility in the two compounds imply that the same magnetic structure and a pseudo-easy axis is also present for X=Br. We estimate the Hamiltonian parameters by combining analytical calculations and Monte Carlo (MC) simulations of the spin-flop and saturation field. The MC simulations also reveal that the spin-flop transition occurs when the applied field is parallel to the pseudo-easy axis. Contrary to conventional easy-axis systems, there exist field directions perpendicular to the pseudo-easy axis for which the magnetic saturation is approached asymptotically and no symmetry-breaking phase transition is observed at finite fields.

Published by the American Physical Society
2024
Point spread function deconvolution using a convolutional autoencoder
Authors: Sreejith Sreevarsha , Slosar Anže , Wang Hong
Published: November 2024

A major issue in optical astronomical image analysis is the combined effect of the instrument’s point spread function (PSF) and the atmospheric seeing that blurs images and changes their shape in a way that is band and time-of-observation dependent. In this work we present a very simple neural network based approach to nonblind image deconvolution that relies on feeding a convolutional autoencoder (CAE) input images that have been preprocessed by convolution with the corresponding PSF and its regularized inverse, a method which is both conceptually simple and computationally less intensive. We also present here, a new approach for dealing with limited input dynamic range of neural networks compared to the dynamic range present in astronomical images.

Published by the American Physical Society
2024
Shot noise and universal Fano factor as a characterization of strongly correlated metals
Authors: Wang Yiming , Setty Chandan , Sur Shouvik , Chen Liyang , Paschen Silke , Natelson Douglas , Si Qimiao
Published: November 2024

Shot noise measures out-of-equilibrium current fluctuations and is a powerful tool to probe the nature of current-carrying excitations in quantum systems. Recent shot-noise measurements in the heavy-fermion strange metal YbRh2Si2 exhibit a strong suppression of the Fano factor (F)—the ratio of the current noise to the average current in the dc limit. This system is representative of metals in which electron correlations are extremely strong. Here we carry out the first theoretical study on the shot noise of diffusive metals in the regime of strong correlations. A Boltzmann-Langevin equation formulation is constructed in a quasiparticle description in the presence of strong correlations. We find that F=3/4 in such a correlation regime. Thus, we establish the aforementioned Fano factor as universal to Fermi liquids, and we show that the Fano factor suppression observed in experiments on YbRh2Si2 necessitates a loss of the quasiparticles. Our work opens the door to systematic theoretical studies of shot noise as a means of characterizing strongly correlated metallic phases and materials.

Published by the American Physical Society
2024
Hide and seek: the patterns, antecedents and underlying mechanisms of knowledge hiding by MNE expatriates
Authors: Zhi Ruoting , Lockett Martin , Zhou Abby Jingzi
Published: November 2024

Purpose

In the knowledge-based view, knowledge is a valuable source of enterprise success. Its transfer through expatriates is a key mechanism in the value proposition of outward foreign direct investment by multinational enterprises (MNEs). Unfortunately, individuals are not always willing to share what they know. Expatriates are crucial players in knowledge transfer, and their knowledge-hiding behavior can significantly inhibit enterprise success. This paper thus aims to explore the patterns and antecedents of knowledge hiding, as well as the underlying mechanisms in the hiding process by expatriates within MNEs.

Design/methodology/approach

This paper focuses on expatriates assigned to emerging economies in Chinese MNEs. It is based on a systematic qualitative analysis of semi-structured interviews with 24 expatriates from 16 companies across 25 countries.

Findings

Not all knowledge hiding should be perceived as a negative behavior, as moderate rationalized hiding can fulfil a positive purpose. Antecedents of expatriates’ knowledge hiding were identified within a framework covering knowledge, individual, organizational and cultural features. Three main scenarios of knowledge-hiding process were also disclosed to illustrate the internal generative logic.

Originality/value

The comprehensive analysis of knowledge hiding presented in this paper enriches the existing literature on cross-border knowledge management and provides novel theoretical insights to better promote knowledge transfer by expatriates. A practical framework of knowledge transfer within MNEs is developed to guide the management of expatriates, even a broader spectrum of knowledge workers.
Balancing act: how family identity orientation impacts careers of NCAA women coaches
Authors: Boiarintseva Galina , Grabarski Mirit K.
Published: November 2024

Purpose

The purpose of this paper is to understand the career experiences of the NCAA women coaches integrating the Kaleidoscope careers model with Family Identity theory.

Design/methodology/approach

We employ qualitative methodology with the use of semi-structured interviews with 18 NCAA women coaches. Using interpretive lens, we offer nuanced descriptions of women career experiences from care and career orientation perspectives.

Findings

Our findings shed light on experience, perceptions and strategies employed by female NCAA coaches while trying to fulfill work and life responsibilities. Care- or Career- orientation impacts the way women coaches deal with different aspects of maintaining careers in sports coaching.

Originality/value

We refine the KCM framework by showing that authenticity, balance and challenge can manifest in different ways, which is particularly important as organizations often struggle with retention of women coaches.
Integrating expert insights and data analytics for enhanced construction productivity monitoring and control: a machine learning approach
Authors: Pourrahimian Elyar , Eltahan Amira , Salhab Diana , Crawford Joe , AbouRizk Simaan , Hamzeh Farook
Published: November 2024

Purpose

This study aims to enhance productivity monitoring and control in the construction industry by integrating data-driven analytics with expert insights.

Design/methodology/approach

A novel framework combines expert knowledge and data analysis to identify productivity trends and devise improvement strategies. A machine learning model predicts productivity ranges using historical data and project-specific factors’ evaluated by surveys, supported by a warning dashboard for proactive decision-making.

Findings

The findings reveal that integrating expert insights with data analytics significantly enhances the ability to monitor and control productivity, leading to proactive strategies for construction stakeholders. The machine learning model demonstrates robust accuracy in forecasting productivity ranges, allowing for early identification of potential issues. The dashboard system proves invaluable, offering semi-real-time alerts and facilitating swift action to prevent productivity lapses. These results highlight the effectiveness of the proposed approach in detecting trends, predicting outcomes and enabling timely interventions, thereby contributing to the overall productivity improvement of construction projects.

Research limitations/implications

There are also limitations to consider, including potential data availability, constraints in the expert pool, implementation challenges and the need for long-term evaluation; these factors should be considered when interpreting the study’s findings and applying the proposed framework to construction projects. Future research can focus on expanding the application of this framework to different types of construction projects and evaluating its scalability.

Practical implications

This study introduces a framework with a warning dashboard for early detection of issues, combining expert insights and data analysis for improved project outcomes. This research suggests a shift toward more expert, data-driven, insightful decision-making in construction, aiming for enhanced performance and reduced disruptions. An important implication of this research is the need to balance digital tools and expert judgment. Project managers are advised to use a holistic strategy that ensures informed and comprehensive decision-making.

Originality/value

This research introduces a unique methodology that blends traditional expertise with modern analytics to address construction productivity challenges. It offers a practical solution for stakeholders to enhance decision-making, resource allocation and project planning, marking a significant contribution to construction management literature.
Predicting project performance from occupational stress, psychological availability and ethical leadership: moderated-mediation and mediated-moderation models
Authors: Abiemo Martin Kwasi , Azila-Gbettor Edem M. , Atatsi Eli Ayawo , Honyenuga Ben Q. , Mensah Christopher
Published: November 2024

Purpose

This study, respectively, explored the mediating and moderating influences of psychological availability and ethical leadership on the relationship between occupational stress and project performance among construction workers in Ghana.

Design/methodology/approach

Employing partial least squares structural equation modelling (PLS-SEM) with SmartPLS 4, this quantitative cross-sectional study analysed survey data from 677 construction project workers who were recruited through simple random sampling technique.

Findings

The results demonstrate that occupational stress negatively predicts both project performance and psychological availability of construction project workers. Psychological availability and ethical leadership mediate and moderate the stress-project performance relationship, respectively.

Practical implications

The findings suggest that ethical leadership and attention to psychological well-being are key to managing occupational stress and enhancing project performance in high-stress environments like construction.

Originality/value

This study contributes to the understanding of occupational stress in project management by integrating psychological and leadership factors through conservation of resource theory, social exchange theory and the job demands-resources model.
The BORIS experience: evaluating omnichannel returns and repurchase intention
Authors: Hao Jianliang , Richey Jr Robert Glenn , Morgan Tyler R. , Slazinik Ian M.
Published: November 2024

Purpose

Researchers have examined the influence of the factors on reducing return rates in retailing over the years. However, the returns experience is often an overlooked way to drive customer engagement and repeat sales in the now ubiquitous omnichannel setting. The focus on returns prevention in existing research overshadows management’s need to understand better the comprehensive mechanics linking the customer in-store return experience with their repurchase actions. Recognizing the need to bridge different stages of the returns management process, this research aims to explore the facilitators and barriers of in-store return activities.

Design/methodology/approach

Analysis of customer corporate data from 5,339 returns at the retail level provides insights from the customer return experience. Expanding our theoretical understanding, a deductive research approach then examines how those factors impact customer repurchase intentions both online and at brick-and-mortar stores. Stage two of the study employs a scenario-based role-playing experiment with consumer respondents to test hypotheses derived from signaling theory and justice theory.

Findings

Results find that returns policy and loyalty program capabilities are essential in creating a positive customer in-store experience. Moreover, a return experience enhanced by frontline employee service can retain existing shoppers and drive additional store traffic, further stimulating retailer sales.

Originality/value

These findings refine our understanding of returns management in evolving omnichannel retailing and offer practical insights for retailers to manage customer relationships through in-store returns.
Co-creating a mentor academy within a school–university partnership: continuity in effective mentoring of teacher candidates, novice teachers and beyond
Authors: Reichenberg Jennifer Sharples , Gallagher Michelle , Dudkowski Gina
Published: November 2024

Purpose

This study investigated a mentor academy that was co-created within a school–university partnership (SUP) to support continuity in high-quality mentoring for teacher candidates, student teachers, novice teachers and teachers new to the school. We explored growth in the mentors and aspects of the academy that impacted that growth.

Design/methodology/approach

This instrumental case study included eight mentors and one administrator participating in six sessions of the mentor academy during one academic year. Data included surveys, an interview, artifacts and notes. Additional survey data were gathered from teacher candidates and novice teachers who were mentees and other administrators. The academy focused on identifying the needs of mentees at different levels of experience, approaches to communication, feedback and observation and building a sustainable and life-giving mentoring program. The constant comparative method was applied within and across sources to reveal themes. Numerical data from Likert scale survey questions were cross-referenced with qualitative data.

Findings

Mentors improved their ability to build trusting relationships with mentees, provide individualized support based on mentees’ developmental levels, confer and offer specific feedback. They learned to mentor for independence, and mentors grew in confidence, suggesting and enacting leadership roles.

Research limitations/implications

This study is limited to data from only one cohort. Furthermore, studying the content of mentoring sessions could provide a more nuanced understanding of mentors’ growth. Therefore, future research will include analysis of mentoring sessions and mentees’ goals and progress.

Originality/value

The mentor academy spanned the school–university boundary by cultivating cohesive mentoring practices, which supported the clinical preparation of teacher candidates, the development of teachers and the professional learning of mentors. The tools, procedures and network created by the mentors contributed to a self-sustaining and life-giving mentoring culture in the SUP.
Miss Rizos: Changing the world, one (black) curl at a time?
Authors: Alcaraz Jose M. , Perdomo Ivelisse , Barrero Fernando , Weilage Christopher E. , Carrillo Valeria , Hollander Rodolfo
Published: November 2024

Research methodology

Data for this case was collected through multiple interviews with the founder, staff and customers of Miss Rizos. In total, about 10 h of interviews were recorded and transcribed. To write the case, the authors visited the firm’s premises in Santo Domingo. Furthermore, observations, participation as clients and informal interactions also resulted in additional data and evidence that supported the case. In addition, the authors consulted corporate documents and archival data, as well as secondary sources, such as internet news, blogs, YouTube and other social media.
Riding the waves of the pandemic – Wolt’s global scaling journey
Authors: Laine Igor , Salihu Diellza
Published: November 2024

Research methodology

The case is primarily based on publicly available data, which includes the company website, industry reports and articles published in various media sources, as well as video-recorded interviews with the company representatives. Some factual data is fetched from or triangulated with public and licensed databases such as Statista, Crunchbase and PitchBook.
Dynamics of China's development: Long–short perspectives on institutions, globalization, technology, and environmental quality using auto regressive distributive lag
Authors: Shuhai Niu , Zeb Ali , Rasheed Mohsin , Ullah Obaid , Din Naeem Ud
Published: November 2024

This study investigates the connections among institutional quality (IQ), globalization, technological innovation, and environmental sustainability in China, using time‐series data from 1995 to 2022. The autoregressive distributive lag model (ARDL) and Granger causality, stability, and diagnostics approaches were employed for rigorous data analysis. Results of the ARDL test reveal that IQ and technological innovation have a negative and significant impact on carbon dioxide (CO2) emissions in the long run. In the short run, globalization has an insignificant impact on CO2 emissions; on the other hand, IQ, technological innovation, foreign direct investment, and economic growth significantly affect CO2 emissions in China. The result of Granger causality also confirmed unidirectional causality running from globalization, technological innovation, and IQ toward CO2 emissions. Furthermore, the NARDL analyses supported this research's findings. The study suggests that implementing effective environmental regulations, improving governance, and promoting transparency and accountability can enhance the enforcement of environmental policies. Although allowing the limited short‐term impact of globalization, planned global engagement associated with ecological goals is also recommended. Furthermore, policy recommendations include investing in research and development of green technologies, incentivizing companies to adopt eco‐friendly practices, and supporting startups focused on environmental solutions, which can drive positive change toward environmental sustainability in China.
Isolating the direct effects of growth hormone on lifespan and metabolism in mice
Authors: Lasher Alexander Tate , Liu Kaimao , Fitch Michael P , Sun Liou Y.
Published: November 2024

Prior studies have shown that interrupting the growth hormone/insulin‐like growth factor‐I (GH/IGF‐I) signaling axis extends laboratory mouse lifespan, but confounding effects of additional gene or hormone deficiencies that exist in commonly used models of GH/IGF‐I interruption obscure the specific effect of GH on longevity. We address this issue by using mice with a specific knockout of the GH gene and show that both males and females on a mixed genetic background display extended lifespans resulting from GH deficiency. Our physiological assessment of these mice revealed that in addition to weighing significantly less and displaying significantly greater body fat (as a percentage of body weight), GH deficient mice display significant impairments in glucose metabolism and preferential fat utilization. These data provide strong evidence that GH deficiency is directly responsible for the altered nutrient utilization and extended lifespan that is commonly observed in mouse models of GH/IGF‐I interruption.
Catheter Ablation of Ventricular Premature Contractions Originating From RVOT With Interruption of the Inferior Vena Cava—A Case Report
Authors: Xiong Liang , Hu Jinzhu , Wang Dandan , Hua Juan , Chen Qi
Published: November 2024

Ventricular premature contractions (VPC) originating from right ventricular outflow tract is the most common type of ventricular arrhythmias in clinic settings, which can be effectively cured by catheter ablation. Interruption of the inferior vena cava (IVC) is a rare vascular anomaly resulting from aberrant development during embryogenesis. Herein, we reported a very rare case of VPC originating from right ventricular outflow tract (RVOT) with interruption of IVC, which was successfully ablated by transfemoral vein approach.
Cost–benefit analysis of landfill emergency securing: Two applications in Southern Italy
Authors: Comincioli Nicola , Romani Ilenia Gaia , Vergalli Sergio
Published: November 2024

The systematic use of landfills as a method of waste disposal is leaving a heavy legacy in terms of environmental pollution, especially in the case of illegal or non‐compliant disposal sites. When no environmental precaution is adopted, harmful substances' release imposes relevant health risk to the surrounding population. This risk is also reflected on the value of nearby assets. To mitigate this pressing problem, the European Union is planning and financing the remediation of thousands of contaminated sites on its territory. Cost–benefit analysis (CBA) is used for assessing the priority of individual projects and for accessing European funding, evaluating the effectiveness of an investment considering the externalities generated. In this paper, we apply CBA to two emergency securing interventions of contaminated sites in Southern Italy. We execute a financial analysis and an economic evaluation of four environmental and social spillovers (reduction of mortality, recovery of real estate and land assets values and landscape enhancement). This study contributes to the literature of CBA applied to environmental projects, proposing a systematic and replicable method for evaluating externalities generated by contaminated sites' emergency securing. Being based on two real case studies, this work allows to compare similar interventions, highlighting the most effective action strategy.
Development of Self‐Management Skills in 14‐ to 16‐Year‐Old Adolescents with Chronic Health Conditions: A Qualitative Study
Authors: Williams Eileen S. , Enzler Cassandra J. , Bretz Lauren , Zimmerman Cortney T. , Hergenroeder Albert C. , Garland Beth H. , Wiemann Constance M.
Published: November 2024

Background

The American Academy of Pediatrics recommends that adolescents with chronic health conditions begin to assume responsibility for their own care by age 14. The goal of this qualitative one‐time interview study is to learn how 14‐ to 16‐year‐old adolescents with chronic health conditions begin to develop self‐management skills and the role that caregivers play in the learning process.

Methods

Twenty adolescents ages 14–16 with chronic renal (n = 5), gastrointestinal (n = 5), hematologic (n = 5), or rheumatologic (n = 5) diseases, and 20 caregivers (dyads), completed individual semi‐structured interviews discussing the adolescents' current degree of self‐management. Six coders analyzed transcripts using thematic framework analysis.

Results

Three primary themes emerged: continuum, motivations, and tools. Both adolescents and caregivers described progress along a self‐management continuum with varying levels of responsibility for the adolescents, ranging from passive to responsible. Caregivers' behaviors similarly varied from directive management to supported self‐management. Motivations for self‐management skills were described in relation to one's health, self, and others. Families utilized a variety of tools to facilitate movement toward supported self‐management with the adolescent.

Conclusions

The development of adolescent self‐management of their chronic condition is a complex, shifting continuum between caregiver and adolescent. This continuum may be impacted by adolescent motivation and tools/problem solving available to the family. Pediatric healthcare providers can support self‐management by assessing and attending to each patient's motivations; building a road map individualized to each patient's skills; and offering time in outpatient clinic to practice self‐management strategies.
Accuracy of Photogrammetry, Intraoral Scanning, and Conventional Impression for Multiple Implants: An In Vitro Study
Authors: Lyu Mingyue , Li Yizhou , Xu Dingyi , Xing Qi , Zhang Shiwen , Yuan Quan
Published: November 2024

Objectives

This in vitro study compared the accuracy of conventional impressions (CNVs), photogrammetry (PG), and intraoral scanning (IOS) for recording implant impressions of edentulous segments, ranging from part to complete arches by different evaluation methods.

Methods

The master model for an edentulous maxillary arch was created with six implants (a–f). CNVs, PG, and IOS were used for impressions. Three impression ranges (bcde, bcdef, and abcdef) were chosen for analysis. The best‐fit algorithm, absolute linear deviation, and angular deviation were used for evaluation. Trueness and precision were analyzed by two‐way ANOVA and the Kruskal–Wallis test, respectively.

Results

The accuracy of multiple implant impressions was significantly influenced by the impression method and impression range (p < 0.05) regardless of the evaluation methods used. At smaller ranges (bcde and bcdef), there was no difference in the trueness of the three impression methods, whereas at a larger range (abcdef), both PG and CNV exhibited similar trueness, which was significantly higher than that of IOS(p < 0.05). The precision of PG was significantly better than that of CNV and IOS in most of cases (p < 0.05). As the range expanded, the trueness and precision of PG and IOS decreased (p < 0.05), whereas the accuracy of CNV remained stable.

Conclusions

In the case of large‐range impressions, PG demonstrated a similar degree of trueness and better precision compared with CNVs, whereas the trueness and precision of the intraoral scanning were worse. This indicated that PG might be a promising method for multiple implant impressions.
Unexpected soundscape response to insecticide application in oak forests
Authors: Mitesser Oliver , Hochrein Sophia , Burivalova Zuzana , Müller Sandra , Strätz Christian , Liebhold Andrew M. , Leroy Benjamin M. L. , Hilmers Torben , Georgiev Kostadin B. , Bae Soyeon , Weisser Wolfgang , Müller Jörg
Published: November 2024

Rachel Carson's warning of a silent spring directed attention to unwanted side effects of pesticide application. Though her work led to policies restricting insecticide use, various insecticides currently in use affect nontarget organisms and may contribute to population declines. The insecticide tebufenozide is used to control defoliating Lepidoptera in oak forests harboring rich insect faunas. Over 3 years, we tested the effect of its aerial application on bird populations with autonomous sound recorders in a large, replicated, full factorial field experiment during a spongy moth (Lymantria dispar) outbreak. The soundscape analysis combined automated aggregation of recordings into sound indices with species identification by experts. After pesticide application in the year of the outbreak, acoustic complexity in early summer was significantly reduced. The soundscape analysis showed that the reduction was not related to birds, but instead to the large reduction in caterpillar feeding and frass dropping. Effects on the vocal activity of birds were smaller than originally expected from a related study demonstrating tebufenozide's negative effect on bird breeding success. The legacy of the pesticide treatment, in terms of soundscape variation, was not present in the second year when the outbreak had ended. Our results showed a dimension of insecticide‐induced acoustic variation not immediately accessible to the human ear. It also illustrated how a multifaceted soundscape analysis can be used as a generic approach to quantify the impact of anthropogenic stressors in novel ways by providing an example of remote and continuous sound monitoring not possible in conventional field surveys.
Environmental impact of the enhanced recovery pathway in colorectal surgery: A simulation study
Authors: Slim Karem , Veziant Julie , Enguix Audrey , Zieleskiewicz Laurent
Published: November 2024

Aim

Most of the literature on the environmental impact of surgery has analysed operating theatre practice in terms of its contribution to global warming (by greenhouse gas effects). The aim of this study was to assess the overall environmental impact of a complete perioperative pathway with and without implementation of an enhanced recovery programme (ERP).

Method

We compared two scenarios: an ERP scenario and a conventional scenario (CONV) for colorectal surgery. We carried out a lifecycle analysis for perioperative procedures, devices and consumables. We measured the impact on 17 environmental variables in addition to global warming.

Results

The overall environmental impact of ERP was 6% lower than that of conventional care. The reduction of impact due to ERP ranged from 5% for greenhouse gas emissions (18 kg CO2 equivalent less per intervention) to 27% for water consumption (3 m3 less). The stages that had the most impact on the environment were the preoperative stage (essentially owing to patient travel) and the intraoperative stage with the surgical part (medical devices representing 83.3% of the impact of the procedure) and the anaesthesia part (halogenated gases and ventilation representing 54.9% of the impact of anaesthesia care).

Conclusion

This study found an ERP approach to be more eco‐responsible than conventional care. This is an additional benefit of ERP implementation. The impact of ERP implementation might be further reduced by action on the preoperative and intraoperative stages.
Exploring English as a Foreign Language Learners’ Adoption and Utilisation of ChatGPT for Speaking Practice Through an Extended Technology Acceptance Model
Authors: Zou Bin , Wang Chenghao , Yan Yiwen , Du Xiaoman , Ji Yuan
Published: November 2024

ChatGPT has garnered significant interest for its potential educational benefits, particularly in aiding English as a foreign language (EFL) learners to develop language skills. This study aims to explore how various internal and external factors, as outlined in the proposed extended technology acceptance model (TAM), influence EFL learners’ acceptance and use of ChatGPT to enhance their oral English. Drawing on the extended TAM questionnaires from 212 Chinese EFL learners and semi‐structured interviews with 12 participants, the research underscores that a positive attitude toward ChatGPT significantly influences learners’ intention to adopt ChatGPT for English‐speaking practice. Moreover, facilitating conditions significantly predict the perceived ease of use. The qualitative results shed light on ChatGPT's effectiveness and convenience in developing English‐speaking skills, its potential to simulate IELTS exams and situational dialogues, and identifying certain scenario‐specific limitations.