bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyzing the impact of population size, regional minimum wage, and economic growth on unemployment
Authors: Sepdianty Ika , Tuah Sunaryo N
Published: January 2024

The problem of unemployment is indeed very complex to discuss, because it can be related to several economic indicators that have a relationship with the open unemployment rate. The role of the government is needed to overcome the problem of unemployment in the region. Uncontrolled population numbers can result in not achieving economic development goals. The success of economic development can be seen from economic growth and the smaller inequality in an area, with the increasing economic development of a region, it is expected to be able to reduce the existing unemployment rate where welfare will be achieved properly. This study has a purpose: to analyze the effect of population, regional minimum wages, and economic growth on the open unemployment rate in Central Kalimantan. This study uses secondary data which is time series data from 2013-2019. Analysis of the data used is panel data with the help of the eviews program. The result of this study is that the variables of population, regional minimum wage, and economic growth have a positive effect on the open unemployment rate in Central Kalimantan. When the population increases and when real wages increase, companies will reduce the demand for labor, while the supply of labor is higher than the demand for labor, then this causes the unemployment rate to increase
BENTUK-BENTUK INTRAKSI SOSIAL PEKERJA SOSIAL DENGAN LANSIA DI SENTRA MEOHAI KENDARI
Authors: Sustira Yuput , Bauto La Ode Monto , Sarmadan Sarmadan
Published: January 2024

Penelitian ini bertujuan untuk memahami Bentuk-Bentuk Interkasi Sosial Pekerja Sosial Dengan Lansia di Sentra Meohai Kendari beserta hambatan yang dihadapi oleh pekerja sosial dalam berinteraksi dengan lanjut usia di Sentra Meohai Kendari. Metode penelitian yang digunakan peneltian ini adalah metode deskriptif kualitatif. Sedangkan teknik pengumpulan data yang digunakan adalah observasi, wawanvara dan dokumentasi. Informan dalam penelitian ini adalah pekerja sosial dan lansia yang ada di Sentra Meohai Kendari. Sumber data yang digunakan adalah sumber data primer dan data sekunder. Hasil penelitian ini menunjukkan bahwa bentuk interaksi yang terjalin antara pekerja sosial dan lansia yang ada disentra meohai kendari yaitu berupa kerja sama, akomodasi, asimilasi, dan konflik. Adapun kendala yang di hadapi oleh pekerja sosial dalam berinteraksi dengan lansia yaitu kondisi fisik dan psikologis lansia, semantik, dan lansia yang memiliki emosi yang tidak stabil

Kata Kunci: Interaksi Sosial, Pekerja Sosial, Lanjut Usia
FDI, Foreign Debt, and Economic Growth: The South Asian Perspective (1980-2020)
Authors: JAMSHEED Rizwan Akhtar
Published: January 2024

The present study examines the intricate relationship between foreign direct investment (FDI), foreign debt, and economic growth over the period of 1980 to 2020 in the following countries: India, Pakistan, Sri Lanka, Bangladesh, Nepal, Maldives, and Bhutan. The analysis utilizes data obtained from the World Bank, with productive projects, improved technology and expertise, technological transfer, foreign direct investment (FDI), export, import, and productive projects serving as independent variables. GDP growth is considered as the dependent variable. The model is subjected to rigorous testing procedures, which include the Fisher-Type ADF (for panel unit root), co-integration tests, histogram-based normality assessment, White test for heteroscedasticity, VIF (variance inflation factor) test for multicollinearity, and F-test for parameter significance. These procedures are implemented to ensure the model's robustness. Subsequent analysis is guided by the Hausman test's preference for the Fixed Effects (FE) model over the Random Effects (RE) model. It is worth noting that in both the FE and RE models, a negative correlation is observed between foreign debt and economic growth. The foreign direct investment (FDI) growth rate is inversely proportional to the growth rate of economic output (0.025 percent) and foreign debt (0.117 percent), according to the FE model. The interdependence of foreign direct investment (FDI) and foreign debt underscores the criticality for developing countries to effectively manage their foreign debt while facilitating FDI inflow. The research emphasizes that policy frameworks in these nations must reduce foreign debt in order to create an environment that is favorable for greater foreign direct investment.
The Use of AI in Predicting Patient Outcomes and Deterioration in the Emergency Department
Authors: Akeel Amal , Aljohani Ayed , Alnasser Osama , Alwabel Abdulmalik , Alsaif Ibrahim , Thabet Atyaf , Bakhsh Abdulmalik , Albuhayri Yasir , Alsalman Ahmed , Aljohani Razan , Abu Suliman Talal
Published: January 2024

The emergency department is an ever-changing environment where patients arrive with a range of conditions and different levels of urgency. One of the struggles for ED healthcare professionals is to assess and manage the risk of clinical deterioration, as it can significantly impact patient outcomes, resource allocation, and decision-making processes. Unfortunately, existing approaches to identifying and responding to patients’ worsening conditions often rely on judgments, lack consistency, or experience delays. Hence, there is a need for objective, dependable, and timely tools to assist ED triage and patient care. Artificial intelligence (AI) is a modern field within computer science that aims to develop systems of performing tasks that typically require intelligence, like learning from data, reasoning logically, and making informed decisions. AI has gained usage in healthcare, encompassing aspects such as diagnosing illnesses, predicting outcomes, providing treatments, and monitoring patients. One area where AI has shown promise is in predicting outcomes and identifying signs of deterioration in the emergency department. This review provides an insight into the advancements in this field, discussing the advantages and challenges associated with utilizing AI to predict patient outcomes and detect deterioration in the ED. It discusses how AI can enhance ED triage and care's accuracy, efficiency, and interpretability by providing objective, timely predictions and explanations. It also tackles the concerns surrounding the quality and accessibility of data, potential biases in algorithms, ethical and legal considerations, human-computer interaction, and the integration of AI into clinical practices. The review concludes by highlighting AI's future directions and implications for patient safety, quality of care, and resource utilization in the ED.
A Comprehensive Review of the Sealing Abilities of Various Root Canal Sealers
Authors: Alakkad Tarik , Burhan Raad , Alsebyani Esraa , Almohaimel Mshael , Alnabet Nouf , Aljepreel Mohammad , Alghamdi Sadeen , Alazmi Awadh , Alkhaldi Sultan , Leslom Mohammed , Alajmi Khulud
Published: January 2024

Preventing oral flora and toxins from penetrating the root canal system and into the periapical tissues is the fundamental idea of successful root canal therapy. For this purpose, the entire root canal system, including the coronal and apical seals, must be obturated. Poor apical sealing allows bacteria to enter the root canal system and produce byproducts, or it allows tissue fluids to seep out, which can cause re-infection and endodontic treatment failure. Therefore, endodontic sealers are considered a cornerstone in the field of endodontics and are essential to the successful completion of root canal fills during obturation treatments. They resolve periapical inflammatory and/or infectious processes and prevent additional microbial contamination. A perfect endodontic sealer should have good adhesion to the canal walls, dimensional stability, insolubility against tissue fluids, sufficient setting time to guarantee working time and biocompatibility. Certain sealers, such as zinc-oxide-based, calcium hydroxide, glass ionomer, and resin, are clinically approved and frequently utilized, although no sealer possesses all of these qualities. Because of its decreased solubility, improved apical seal, microretention to root canal dentin, and decreased shrinkage, epoxy-resin-based sealers are utilized. Several research studies have demonstrated encouraging characteristics, particularly biocompatibility, antimicrobial qualities, and certain bioactivity of calcium-silicate based sealers. Zinc oxide eugenol sealer continues to be the most widely used sealer in many regions of the world.
Orthopedic Complications in Diabetes: Charcot Foot, Neuropathy, and Surgical Considerations
Authors: Aborukbah Abdullah , Alghamdi Faisal , Elbashir Hisham , Alghamdi Abdulaziz , Alzahrani Ahmed , Alghamdi Mohammed , Baseem Saber , Almalki Fahad , Shehata Manar , Alkindy Mohanad , Algaidi Marwan
Published: January 2024

Orthopedic problems in individuals with diabetes are complex and challenging to handle. Among these issues, Charcot foot stands out as a debilitating condition characterized by joint destruction and deformities. This condition is closely linked to neuropathy and inflammation, leading to bone weakening and joint damage. Unfortunately, Charcot foot often goes unnoticed until significant complications arise, underscoring the importance of recognition and intervention. Diabetic neuropathy, affecting around half of all people with diabetes, further complicates challenges by causing loss, autonomic dysfunction and muscle weakness. Sensory loss in the feet puts individuals at risk for injuries, ulcers, and other complications. The diverse symptoms associated with neuropathy impact patients daily. Require individualized management strategies. Surgical considerations in patients add a layer of complexity to their care. Thorough preoperative assessments, infection control measures, vascular evaluations and careful postoperative monitoring are crucial for surgical management. Collaboration among healthcare professionals from specialties is vital for optimizing outcomes. Effective management strategies for these complications involve offloading pressure on affected areas to prevent injury or trauma, maintaining tight glycemic control to minimize complications, providing pain relief to alleviate discomforts experienced by patients and implementing rehabilitation programs that enhance functionality. It is crucial to prioritize identification, prompt intervention, and thorough patient education to achieve results and enhance the overall well-being of individuals with diabetes. To summarize, managing orthopedic issues in patients necessitates a comprehensive strategy that takes into account the complexities of Charcot foot diabetic neuropathy and surgical treatments.
Dynamic Surface Tension of a Charged Spherical Water Drop
Authors: Grigor’ev A. I. , Kolbneva N. Yu. , Shiryaeva S. O.
Published: January 2024

In the asymptotic calculations of the first order of smallness by the dimensionless amplitude of oscillations of the water drop, the effect of the dynamic surface tension on the parameters of oscillations was investigated on the model of an ideal uncompressible liquid. It was shown that the effect of the dynamic surface tension is significantly manifested at the frequencies of the external influence of the order inverse to the water relaxation time. At such frequencies, under the influence of the external influences, the double electric layer is destroyed (there is a violation of the order of water molecules in the near-surface layer), the free energy of the surface increases, and, with it, the value of the surface tension of the liquid. The dynamic surface tension affects the acoustic radiation from the droplet through a change in the value of the surface tension coefficient. The contribution to electromagnetic radiation of the oscillating droplet is associated with the destruction of the ordering of the near-surface water molecules in the double electric layer.
(NESREA) and the Challenges of Environmental Regulation in Nigeria
Authors: Okechukwu Nwachukwu
Published: January 2024

The paper is an assessment of several efforts undertaking as well as challenges faced by National Environmental Standards Regulatory and Enforcement Agency (NESREA) being the regulator in enforcing the provisions of various environmental laws which have been enacted from independence to the present as an unwavering answer to dealing with environmental threats challenging Nigeria as a country. The work examines the effectiveness of NESREA in Nigeria as an enforcement agency, looks in brief the environmental challenges to economic development of Nigeria and the well-being of its citizenry in line with the national and international provisions for environmental assessment in Nigeria. This work employed the use of primary and secondary sources in gathering of information. The paper identified a lot of challenges confronting NESREA to include flagrant abuse of environmental laws without commensurate penalties, weak enforcement, corruption on the part of the staff of the regulatory agency, poor public enlightenment education while also advocating for the reinforcement of the regulatory institution to make room for a broader participation, an elaborate supervisory, monitoring and enforcement of environmental rules, laws and principles.
Stability Indicating HPTLC Method Development and Validation for Acebrophylline in Bulk and its Tablet Dosage Form
Authors: Maruti Kashid Arun , Chandrakant Khilare Amey , Balasaheb Sable Shivanjali
Published: January 2024

A simple, precise, accurate stability-indicating method was developed and validated for Acebrophylline in bulk and tablet dosage form. The chromatographic separation was achieved by using Methanol: Acetonitrile: Acetone: Formic acid (4:4:2:0.1 v/v/v/v) as mobile phase and UV detection at 272nm. The retention factor for Acebrophylline was found to be 0.74±0.10. The developed method was validated with respect to linearity, accuracy, precision, limit of detection, limit of quantitation, and robustness as per ICH guidelines. Results were found to be linear in the concentration range of 400-2400ng band -1 with a correlation coefficient of 0.9921. The % assay was found to be 102.4±5. The drug was subjected to stress conditions of hydrolysis (acid, base), oxidation, photolysis, and thermal degradation. The developed method can be used for the quantification of drug in the dosage form, bulk drug as well as for routine analysis in quality control laboratories.
Development and Validation of RP-HPLC Method for the Estimation of Linezolid from Bulk and Formulations
Authors: Farkade Kalyani , Salode Vikrant , Kadu Tejashri
Published: January 2024

A new, simple, rapid, selective, precise and accurate isocratic reverse-phase high-performance liquid Chromatography assay method has been developed to estimate Linezolid in tablet formulations. The separation was achieved using column Inert sustain C18 (250×4.6mm, 5µ) in the mobile phase consisting of methanol: 1% Acetic acid (50:50 v/v). The flow rate was 0.80mL/min-1, and the separated Linezolid was detected using a UV detector at 249nm. Column temperature 45°C and sample temperature ambient and injection volume 20µL. The retention time of Linezolid was noted to be 7.3min. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent.
Oral Dispersible Tablet: A Review
Authors: Kumar Patel Pradeep , H. S Keerthy , Sharma Mukesh , Paul Malay , T. P Sowmya
Published: January 2024

Demand for ODT is increasing day by day particularly in pediatric, geriatric and patients with some sort of disabilities in swallowing. ODTs are those tablets which gets rapidly dissolved in saliva. They do not need water for administration. Oral dispersible tablets are also known as fast melting tablets. The current article reviews the introduction, ideal characteristics, advantages and disadvantages, limitations, challenges in formulating ODTs, formulations of ODTs, technologies used in ODTs, selection of superdisintegrants and evaluation methods.
Assessment of the Prevalence, Risk factors of Internet Gaming Disorder and Psychological correlates in general population of North India
Authors: F. Shah Aitisam , H. Khan Jahangir , Patil R.K. , Gupta Ramit
Published: January 2024

Background: In 2013 American psychiatric association decided to incorporate internet gaming disorder as non-substance addiction. This study aimed to find the prevalence and risk factors. Methodology: It was a cross-section observational study conducted on a general population. The sample size was time limited. A valid standard questionnaire (PHQ-9, IGDS, GAD-7 Scales) was used to collect data. Result: There was 82 male and 43 female involved in this study. The prevalence of internet gaming disorder was 16.8%. Out of 125 subjects, a total of 21 had internet gaming disorder. There was a significant association between internet gaming disorder and age, gender, economics, profession, living alone, spending more than 3 hours on games, and non-functional family. Anxiety and depression were significantly associated with internet gaming disorder at a value of 0.015.
Proteomics: Technology, Challenges and Advances
Authors: I. Patel Ajay , R. Vyas Darshita , J. Vyas Amitkumar , B. Patel Ashok , V. Dudhrejiya Ashvin , J. Chotaliya Urvi
Published: January 2024

Proteomics is the study of proteins and involves the applications of technologies for the identification and quantification of overall proteins present content of a cell, tissue or an organism. Proteomics is developing fast due to the growing number of proteins obtained by recombinant DNA technology. Proteomics-based technologies are utilized in various capacities for different research settings such as the detection of various diagnostic markers, candidates for vaccine production, understanding pathogenicity mechanisms and interpretation of functional protein pathways in different diseases. Protein analysis employs various techniques and methods, which helps to study the proteomics. While the potential is great, many challenges and issues remain to be solved such as mining and integration of the proteomics. Over the last decade, technological advances in proteomics have driven or increased the capability of proteomics discovery. This review efforts to describe various technologies for the protein analysis, challenges and recent advances employed in the field of proteomics.
A Documrntary Study of Drug Price Control Order (DPCO Act)
Authors: B. Patel Ashok , D. Dabgar Yash , I. Patel Ajay , J. Vyas Amitkumar , V. Dudhrejiya Ashvin , K. Patel Nilesh
Published: January 2024

The drug costs in India are managed the use of what's referred to as the Drugs (Prices Control) Order (DPCO). The DPCO is an order issued with the aid of using the authorities below Section 3 of the Essential Commodities Act, 1955 empowering it to repair and modify the costs of critical bulk drugs and their formulations. The order contains a listing of bulk drug whose costs are to be managed, the technique for fixation and revision of costs, the technique for implementation the technique for restoration of drugs, the consequences for contravention and diverse different recommendations and directions. The order is challenge to the recommendations of Drug Policy and supposedly targets to make sure equitable distribution, accelerated deliver and reasonably-priced availability of bulk drugs. In this paper, I searching for to study the character of deregulation of drug costs that has befell in India over the years and the effect of the identical at the pharmaceutical industry.
A Review on H3N2 Influenza Virus
Authors: Kangude Dnyanda , Mankar S. D.
Published: January 2024

The aim of this review is to discuss the influenza A i.e H3N2 influenza virus with their characteristics. Here we present the outline of the treatment regarding the H3N2 infection, precautions to be taken. The review focused on the symptoms and prevention of H3N2 influenza virus infection. It also highlites on the recent changes in new H3N2 influenza virus and focused on vaccinations against influenza, which researchers are currently developing to study these virus. Moreover this review states that the H3N2 influenza virus are rapidly altered themselves in different ways. The study also shows that the biology of influenza and adaptation acquired by new H3N2 influenza A virus create difficulties in future and current also to predicting the changes. Study of viral growth and their transmition. This review provides support and guide the researcher in the study and better understanding of influenza viruses.
First Generation Hazardous Waste Inventory for Developing A Master Plan for Hazardous Waste Management in Myanmar
Authors: Karstensen Kåre Helge , Saha Palash Kumar
Published: January 2024

Hazardous Waste Management (HWM) is an emerging priority in Myanmar, with the Environmental Conservation Department (ECD) under the Ministry of Natural Resources and Environmental Conservation (MONREC) acting as the nodal authority. Before the initiation of the HWM project in 2015,
funded by the Norwegian government, Myanmar lacked essential regulations and statistical data concerning hazardous waste. The country formally ratified the Basel Convention in January 2015, mandating environmentally sound disposal of hazardous waste by its signatories. Crucial for effective
waste management, hazardous waste generation information is fundamental for planning, implementation, and monitoring. Initial development stages involve the creation of first-generation inventories, which identify priority waste streams, sources, risks, and key stakeholders through basic calculations
and management practice reviews. Myanmar's first-generation hazardous waste inventory, conducted from June 2016 to 2018, estimated that in 2017, approximately 280,600 tonnes/year of hazardous waste were generated, with projections foreseeing a 2.4-fold increase by 2030. Challenges in private
industries, where waste streams, including hazardous waste, are often uncontrolled, led to underestimation of quantities. Data collection, however, employed cross-verification, site visits, and extensive consultations with the technical task force to enhance accuracy. This paper presents the
purpose, methodology, major findings, and challenges faced during the formulation of Myanmar's first-generation hazardous waste inventory.
Sustainable Approach for Using M-Sand Slurry as a Controlled Low Strength Material
Authors: Devaraj Vigneshkumar , Mangottiri Vasudevan , Balu Soundara
Published: January 2024

The national-level practice of handling and disposal of industrial wastes create many challenging environmental implications including extensive pollution, resource seclusion and economic losses. The assessment of potentiality for their reuse and/or recycling has conceived tremendous
opportunity in various engineering applications with a clear insight of circular economic sustainability. Meanwhile, the handling and disposal of mining wastes were posing serious environmental challenges for their substandard engineering properties. To restore the conventional, backfill materials,
a flowable fill known as controlled low strength materials (CLSM) consisting of various ingredients of fine aggregate-sized materials can be employed. In general, CLSM mixtures consist of routinely available materials such as Portland cement, fly ash, fine aggregate, and water. It was expected
that the vital characteristics of the mixture, such as flowability, excavatability, and requirements of minimum mechanical strength compared with concrete enable the use of industrial wastes for the production of CLSM. The present study deals with the feasibility of regenerating the silt fraction
of M-Sand, known as M Sand Slurry (MSS), to be used for the creation of flowable fills. Mix proportions are developed based on the plastic and mechanical properties with a small quantity of cement and water content. Preliminary plastic (flowability) and hardening properties (compressive strength)
results indicate that' s the possibility of the effectiveness of MSS by minimizing the cement addition (up to a maximum of 6%) to attain the unconfined compressive strength above 0.7MPa as per the specifications recommended by ACI standards. It was proposed that an optimum combination of materials
can be effectively incorporated in preparing CSLM materials while reducing the requirements of cement, thereby analysed the cost benefits for sustainable developments.
Health and Safety Risks Among Informal Solid Waste Pickers in Kinondoni Municipality, Dar Es Salaam Region, Tanzania
Authors: Luvanda Faraja , Sweya Lukuba N. , Mwageni Nicholaus
Published: January 2024

Waste pickers in Dar Es Salaam play a great role in managing wastes, however; their health and safety status is not documented with certainty. The objective of the study was to assess the health and safety risks among informal solid waste pickers. The study deployed interview and questionnaire
to collect data. The study revealed that most waste pickers are poor and marginalized social groups. The health and safety status of waste pickers is affected by long working hours, repetitive movement for picking waste, walking long distances carrying heavy bags of recyclables, and working
on hazardous environments without personal protective gears. The most common health and safety risks were musculoskeletal diseases, accidents and injuries. The waste pickers' vulnerability to the hazards is exacerbated by inadequate awareness on health and safety problems, lack of personal
protective equipment and medical insurances. Formal recognition of waste pickers, educational support on health and safety including the use of personal protective equipment (PPE), and medical insurances are needed to lessen their exposure to various risks. The government and private sector
are encouraged to invest in waste recycling activities which create employment opportunities while protecting the environment. At the same time, they should pay attention to waste pickers who, despite the challenges they face, form an integral part on successful recycling activities.
PENERAPAN MEDIA KARTU GAMBAR HIJAIYAH DALAM MENGENALKAN HURUF HIJAIYAH PADA ANAK DI TPQ AN NOUR AL ISLAMY KESUGIHAN
Authors: Kharisma Fauziah
Published: January 2024

Penelitian ini terkait dengan penerapan kartu bergambar huruf hijaiyah sebagai media untuk menunjang kemampuan anak dalam membaca huruf hijaiyah secara baik sehingga anak dapat dengan mudah membaca Al-Qur’an. Dengan fenomena kejadian yang sedang terjadi di TPQ An-Nour Al-Islamy ada sebagian anak yang masih kurang lancar dalam mengenal dan melafalkan huruf hijaiyah. Pada penelitian ini  5 anak yang menjadi sample. Yang mana 3 anak laki-laki dan 2 anak perempuan.  Penelitian ini menggunakan metode kualititif dengan pendekatan penelitian tindakan kelas. Data diperoleh menggunakan tekhnik wawancara, observasi, dan dokumentasi. Dan keabsahan data di cek melalui triangulasi data. Pada penelitian ini dilakukan dua siklus. Dikarenakan pada siklus pertama anak belum mencapai kriteria yaitu anak dapat mengurutkan huruf hijaiyah, membedakan huruf hijaiyah dan melafadzan huruf hijaiyah secara benar. Sehingga peneliti mengadakan siklus ke 2 yang aman di harapkan anak dapat mencapai tingkat kriteria yang di tentukan. Dan kesimpulan yang di dapat meskipun belum sepenuhnya 100 persen berhasil setidaknya anak sudah mengalami peningkatan.
PERAN GURU DALAM MENGEMBANGKAN PERILAKU TERPUJI DI RA DIPONEGORO 193 KARANGMANGU
Authors: Narwen Narwen
Published: January 2024

Gaya hidup, pembulian, atau prilaku tidak baik memberikan bukti bahwa prilaku baik (akhlakul karimah) penting diberikan sejak dini. Dengan menerapkan akhlakul karimah sejak dini kekacauan prilaku dapat teratasi. Penelitian ini bertujuan untuk mengetahui proses guru dalam mengembangkan perilaku baik (akhlakul karimah) pada anak usia dini di RA Diponegoro 193 Karangmangu Kecamatan Purwojati. Penelitian menggunakan metode kualitatif dengan pengambilan data menggunakan observasi, dokumentasi dan wawancara. Hasil penelitian lapangan guru mengembangkan akhlakul karimah yaitu:1) pembiasaan rutin berdoa sebelum dan sesudah kegiatan 2) pembiasaan spontan sopan dan santun dalam perilaku sehari-hari, 3) Keteladanan yang baik hormat menghormati dengan orang lain, 4) membimbing anak mampu bersikap hormat pada orangtua maupun sesama. Temuan tersebut dapat diterapkan di sekolah maupun lingkungan keluarga guna mengembangkan perilaku baik (akhlakul karimah) bagi anak usia dini.
Kiểu hình và bất thường di truyền hiếm gặp của hội chứng Prader-willi: Báo cáo ca bệnh
Authors: Lan An Thuỳ , Mộc Hoàng Thị Thanh , Nga Trần Thị , Nhung Đinh Thị Hồng , Liễu Lê Thị , Ngọc Ngô Thị Bích , Huy Nguyễn Xuân , Huyền Trần Thị , Thuỷ Dương Thị Thu , Tuấn Phạm Quốc , Chung Hoàng Tiến , Tiến Ngô Mạnh , Mai Nguyễn Thị Phương , Thảo Bùi Phương , Ngọc Ngô Diễm
Published: January 2024

Hội chứng Prader-Willi (Prader-Willi Syndrome - PWS) là một trong những hội chứng bệnh di truyền hiếm gặp do mất hoạt động chức năng của các gen trên nhánh dài gần tâm vị trí q11.2-q13 của nhiễm sắc thể (NST) số 15 có nguồn gốc từ bố. Tỉ lệ mắc bệnh trong quần thể ước tính 1/10.000 - 1/30.000. Biểu hiện lâm sàng của hội chứng đa dạng, nặng nề diễn biến từ giai đoạn bào thai đến giai đoạn người trưởng thành, bao gồm: giảm cử động thai, giảm trương lực cơ, béo phì, chậm phát triển tâm thần, tầm vóc thấp, bộ mặt bất thường, thiểu năng sinh dục và hầu hết vô sinh. Nghiên cứu này báo cáo một trường hợp trẻ nam 1 tháng tuổi mắc hội chứng Prader-Willi mang bất thường NST hiếm gặp 47,XY,+min(15)(qter->q11.1:) với biểu hiện lâm sàng đa dị tật gồm: bộ mặt bất thường, giảm trương lực cơ, ăn uống khó khăn, ẩn tinh hoàn hai bên. Áp dụng kĩ thuật phân tích methyl hoá xác định người bệnh mắc PWS thể hai NST 15 có cùng nguồn gốc mẹ (Uniparental Disomy).
Chất lượng cuộc sống của nhóm nam quan hệ tình dục đồng giới đang điều trị ARV tại Hà Nội
Authors: Hồng Vũ Thị Bích , Tú Vương Đình Anh , Anh Vũ Minh , Linh Lê Khánh , Diệp Trịnh Ngọc , Thắng Phạm Hồng , Hạnh Nguyễn Thị Thuý , Giang Lê Minh
Published: January 2024

Nghiên cứu này nhằm đánh giá chất lượng cuộc sống và xác định một số yếu tố liên quan tới chất lượng cuộc sống của nhóm nam quan hệ tình dục đồng giới (MSM) đang điều trị ARV tại một số phòng khám ngoại trú tại Hà Nội năm 2022. Nghiên cứu mô tả cắt ngang được thực hiện trên 212 MSM đang điều trị ARV và sử dụng công cụ đo lường chất lượng cuộc sống WHOQOL-HIV BREF. Kết quả nghiên cứu cho thấy: trên thang điểm từ 4 đến 20, điểm trung bình chất lượng cuộc sống của nhóm MSM là 13,79 điểm (ĐLC = 2,02), trong đó lĩnh vực Sức khỏe thể chất cao nhất 14,40 điểm (ĐLC = 2,45, điểm trung bình chất lượng cuộc sống lĩnh vực Quan hệ xã hội thấp nhất 12,93 điểm (ĐLC = 2,55). Một số yếu tố liên quan ảnh hưởng tiêu cực đến chất lượng cuộc sống của MSM nhiễm HIV như tình trạng lo âu và trầm cảm, bị kỳ thị, công việc không ổn định cũng như yếu tố về bệnh tật (mắc bệnh nhiễm trùng cơ hội).
Evaluation of hematological parameters, oxidative stress, Iron and unsaturated Iron binding capacity levels in Kangal shepherd dogs, before and after orchiectomy
Authors: Yurdakul Ibrahım , Uslu Barıs Atalay
Published: January 2024

Gonadectomy is a widely used method in reproductive health management, and behavior disorder therapies of domestic animals. Anemia and its development, one of the complications of surgical castration, which has been done so much recently in shelter dogs and dogs kept at home, has been investigated in male Kangal shepherd dogs. In castrated male Kangal shepherd dogs was to investigate the relationship between gonadectomy and oxidant and antioxidant levels, Iron (Fe) concentrations, unsaturated iron binding capacity (UIBC) and some blood parameters (RBC, HGB, HCT, MCV, RDW, MCHC). Blood samples were taken from 20 adult Kangal dogs brought to a clinic before castration (Day 0) and on the 1st, 3rd and 7th days. Some biochemical analyzes and blood parameters were evaluated in the blood samples taken. For this purpose, serum total oxidant–antioxidant capacity (TAC–TOC), Iron (Fe) concentrations, unsaturated iron binding capacity (UIBC) and some blood parameters (RBC, HGB, HCT, MCV, RDW, MCHC) were examined. In this study, it was evaluated the relationship between gonadectomy and oxidant–antioxidant capacity and Fe metabolism at some serum parameters in male dogs. After the orchidectomy operation, a remarkable decrease in clinical and statistical blood parameters was observed. As a result of this study, in the analysis of blood parameters, a severe picture of anemia was observed. It was determined an important role in erythropoiesis, with orchidectomy. The statistical difference in blood parameters (P<0.05) was indicative of this.
Strategii argumentative în discursul epideictic al lui Elie Wiesel
Authors: DUMITRU Ștefan
Published: January 2024

În articol sunt prezentate diversele strategii retorice utilizate de Elie Wiesel în argumentarea propriei poziții într-un dublu dialog: în primul rând, cu auditoriul, și indirect cu forțele decizionale la nivel mondial, în al doilea rând, cu istoria. Cu discreție, dar în același timp cu vigoare argumentativă, el aduce în fața publicului imaginea suferinței la care a participat direct în lagărele de concentrare și, revenind permanent la tema indiferenței oamenilor față de ea, își exprimă speranța că respectiva experiență nu se va mai repeta în viitor. Reușește să convingă auditoriul și, totodată, să-l impresioneze adânc atât prin varii tipuri de argumente decelabile, cât și prin strategii retorice, conduse cu rafinament, discreție și detașare. Includerea sa în antologia lui Simon Sebag Montefiore, la care am făcut în permanență referire (Discursuri care au schimbat lumea), este pe deplin justificată: bine articulat, echilibrat argumentat prin exploatarea vizibilă a resurselor de natură etică și afectivă, el nu poate și nu se cuvine să rămână fără ecou în fața celor două tipuri de public căruia i s-a adresat (contemporan și atemporal).
Abordări esențiale privind utilizarea dronelor de luptă. Elemente specifice conflictului armat din Ucraina
Authors: MINCULETE Gheorghe , PĂSTAE Veronica
Published: January 2024

Deși au fost utilizate cu mulți ani în urmă de către forțele multinaționale care au acționat în coaliție și alianță în teatrele din Irak și Afganistan, dronele de luptă, cunoscute sub denumirile de aeronave fără pilot (”unmanned aircraft systems/UAS”, ”unmanned aerial vehicles/UAV”, ”unmanned combat aerial vehicles/UCAV” sau ”remotely piloted vehicle/RPV”) reprezintă o armă redutabilă atât pentru armatele statelor NATO, cât și pentru forțele ambelor state adverse care se confruntă militar în Ucraina. În funcție de caracteristicile de bază, de dimensiuni, de capacitatea de încărcare, de viteză, de raza de acțiune, de flexibilitate, de ușurința de operare și de costuri, aceste mijloace de luptă prezintă avantaje reale în atingerea obiectivelor operaționale ale structurilor combatante, indiferent de categoria de forțe din care fac parte. Prin cele relevate, studiul prezent cuprinde o abordare teoretică, cu impact aplicativ în sfera operațională militară, fiindcă include detalii de referință esențială, focusate pe dronele de luptă, concepute, produse și utilizate de statele beligerante și nebeligerante, raportate la conflictul armat care se desfășoară pe teritoriul statului ucrainean. Din obiectivul studiului, au rezultat o serie de direcții importante în practica consolidării potențialului acțional al forțelor joint și tactice, destinate angajării în context național și multinațional în cadrul Alianței Nord-Atlantice împotriva forțelor agresive ale unui stat advers.
Semnale de avertizare privind stadiul avansat de radicalizare islamică
Authors: DRĂGAN Iulia-Mihaela
Published: January 2024

Articolul analizează principalii indicatori la nivel cognitiv și comportamental care pot fi observați ca urmare a manifestării procesului de radicalizare islamică, respectiv stadiul avansat de radicalizare. De asemenea, sfera de cercetare se raportează la identificarea semnalelor la radicalizare islamică, prin utilizarea unei metodologii bazate pe analiza cazurilor de radicalizare a cetățenilor români. Cum cercetarea vizează analiza principalelor semnale care trădează stadiul avansat de radicalizare individuală, acești indicatori prezintă utilitate pentru avertizarea timpurie atât din perspectiva practicienilor și autorităților competente în prevenirea și combaterea radicalizării, cât și pentru societatea civilă, în vederea creșterii gradului de conștientizare cu privire la identificarea discursului radical întâlnit în mediul online.
واقع الإعلان الرقمي في عصر استراتيجيات التسويق الإلكتروني.. الفرص والتحديات
Authors: مختار ساطور محمد
Published: January 2024

يقوم الإعلان الرقمي بدور هام في عصر الاندماج مع التسويق الإلكتروني، نظرا للتطور التكنولوجي الهائل الذي يعيشه العالم الآن، الذي انعكس بالنجاح على مؤسسات الأعمال المختلفة. هذا البحث يدرس الإعلان الرقمي في العصر الحالي، من أجل التعرف على الواقع الإعلاني الذي نعيشه الآن، حيث إنه حدث تحول كبير في أنواع المنصات المستخدمة، وتغيرت أنواع الإعلانات، كما إن التسويق الإلكتروني أصبح يحظى بالاهتمام الأكبر من قبل المعلنين، وظهرت استراتيجيات تسويقية جديدة لم تكن معروفة من قبل، في الدراسة، تم التعرض لأنواع المنصات الإعلانية الرقمية الخاصة به، والأنواع المختلفة للإعلانات الرقمية على شبكة الإنترنت، والتسويق الإلكتروني، والتخطيط الاستراتيجي له، وأنواع الاستراتيجيات التسويقية الإلكترونية، والمزيج التسويقي، وآثار التسويق الإلكتروني على مكوناته، وكذلك الفرص والتحديات. وتوصلت الدراسة إلى أن عالم الإعلان والتسويق حاليا ومستقبلا هو عالم الفضاء الرقمي الإلكتروني، وأن الرسائل الإعلانية أصبحت عالمية تناسب وتنسجم مع شعوب العالم المختلفة. كما أن الإعلان الرقمي والاستراتيجيات التسويقية لهم أنواع كثيرة، مما يجعلها قادرة على الوصول والتأثير على الجمهور بشكل كبير وفعال ومؤثر. وأوصت الدراسة بضرورة استخدام رواد الأعمال للإعلانات الرقمية والتسويق الإلكتروني للترويج لأعمالهم التجارية الصغيرة، وأهمية تحول مؤسسات الأعمال الحكومية والخاصة إلى استخدام الإعلان الرقمي، والتسويق الإلكتروني.                                                                                                          

الكلمات المفتاحية: الإعلان الرقمي؛ المنصات؛ استراتيجيات؛ التسويق الإلكتروني؛ المزيج التسويقي.
Ethnobotanical study of medicinal plants used in the prevention and treatment of COVID-19 infection in the Tiaret region (Algeria)
Authors: Leila Soudani , Meriem Chafaa , Souad Benabdelkrim , Rekaia Houcine
Published: January 2024

The Corona Virus disease has spread widely over the world with a high mortality rate. This spread has prompted people to look for other ways to treator minimize the negative impact of this out break. During the pandemic, the Algerian population used medicinal plants for the prevention and treatment of COVID-19. The present work was carried out to identify the medicinal plants used during COVID-19 by the population of Tiaret region (Algeria). An ethnobotanical survey was conducted to collect data on the medicinal plants used, including the socio demographic parameters of the users and floristic characteristics of the plants. Information was obtained from 428 participants, of which 67.05% were women, aged between 16 and 88 years old. Most plant users were between 41 and 64 years old. The majority of participants have a high level of education (55.14% university and 20.32% secondary). Quantitative indices, namely, Frequency of Citation (FC), Relative Frequency of Citation (RFC) and Family Importance Value (FIV) were used to analyze the data. 27 species of medicinal plants belonging to 15 botanical families used during the COVID - 19 pandemic in our region. The most used species were Syzygium aromaticum, Zingiber officinale, Citrus limon and Aloysia citriodora.
Advances and Challenges in Closed Loop Therapeutics: From Signal Selection to Optogenetic Techniques
Authors: Pedro Francisco
Published: January 2024

The main objective of this paper is to develop closed-loop therapeutic systems by reviewing various neurological disorders. We propose a system that incorporates a biosensor, controller, and infusion pump to provide closed-loop feedback management of medicine delivery. To address the specific therapeutic requirements of a medication called Dox, they made precise adjustments to the system's functioning. The device incorporates a biosensor capable of real-time assessment of medicine levels in the bloodstream. The method utilizes aptamer probes that have been labeled with an electrochemical tag. When these probes connect to the drug target, they undergo a reversible change in shape, leading to a modification in redox current. A little quantity of blood is consistently extracted from the animal's circulatory system inside a microfluidic device, which is used for this measurement. The paper examines the challenges of seizure detection and the use of advanced learning algorithms and classification methods to enhance real- time seizure detection in closed-loop systems. Following the successful use of optogenetic techniques in epilepsy models, the authors discuss the potential of these technologies for controlling brain activity.
Inibidores do Cotransportador de Sódio-Glicose 2 em Receptores de Transplante Renal – um Estudo Retrospectivo de Centro Único
Authors: Freitas Joana , Francisco José Teixera , Trigo Miguel , Carvalho Renata , Vilela Sara , Silvano José Luís , Ribeiro Catarina , Malheiro Jorge , Pedroso Sofia , Almeida Manuela , Fonseca Isabel , Martins La Salete
Published: January 2024

Introdução: Considerando o aumento da incidência de diabetes pós-transplante e o elevado impacto cardiovascular entre os receptores de transplantes, este facto faz com que o uso de inibidores de SGLT2 nesse grupo seja atrativo devido aos seus benefícios cardiovasculares e renoprotetores. No entanto, há escassez de evidência nos receptores de transplante renal com diabetes devido a preocupações com possíveis danos ao enxerto renal e efeitos adversos. Métodos: Este estudo retrospectivo foi elaborado para avaliar a eficácia e segurança dos inibidores de SGLT2 em receptores de transplante renal (KTRs). O foco principal foi avaliar o seu impacto em parâmetros como níveis de hemoglobina A1c, índice de massa corporal (IMC), perfil lipídico, níveis de hemoglobina, função do enxerto renal (taxa de filtração glomerular estimada) e relação proteína/creatinina urinária. Resultados: Um total de 75 pacientes receptores de transplante renal foram incluídos em nossa investigação. O estudo abrangeu um período de observação mediano de 18 (2,0–71,0) meses. A taxa média de filtração glomerular estimada no início foi de 61,9 (26–120) mL/min/1,73 m2 e permaneceu estável durante o acompanhamento. A mediana da HbA1c diminuiu de 7,5 para 7,0% (IC 95%; p<0,002). A melhora significativa no IMC (IC 95%; p<0,001) e no perfil lipídico (IC 95%; p<0,05) também foram observados. A taxa média de hemoglobina no início foi de 13,5g/dL e melhorou modestamente no final do acompanhamento para 13,7g/dL (p=0,12). Em relação à relação proteína/creatinina urinária, os níveis aumentaram ligeiramente, mas não significativamente [+0,05 g/g (p=0,9)]. Numa análise de subgrupo post-hoc, a taxa de infecções do trato urinário foi baixa (10%). Nenhum outro efeito colateral foi observado durante o curso do tratamento. Conclusões: Este estudo demonstra que a administração de inibidores de SGLT2 é viável e bem tolerada, sem efeitos colaterais notáveis em receptores de transplante renal. No entanto, a questão de saber se a inibição do SGLT2 pode efetivamente reduzir a mortalidade cardiovascular e melhorar a sobrevida do enxerto nesses pacientes permanece a ser explorada em estudos subsequentes.
The urgency of an early warning system for social conflict by using WhatsApp
Authors: Rochana Erna , Ikram  , Raidar Usman , Sari Yuni Ratna , Fahmi Teuku , Susilawati  , Muhammad Ulul Azmi
Published: January 2024

The purpose of the study is to use integrated information technology to demonstrate the importance of the Early Warning System (EWS) for social conflicts that involve public participation. This study used a mixed-methods approach. A total of 267 respondents were involved. Data were collected using a questionnaire covering household socio-demographic characteristics, smartphone use, religious tolerance, inter-ethnic tolerance, social cohesion, social capital and participation in conflict prevention. The Focus Group Discussion (FGD) was carried out in four villages involving 12 people. The majority of respondents in this survey fall into the medium and high category when it comes to the respondents' inclination in the five variables: smartphone use, social capital, inter-ethnic tolerance, religious tolerance and social cohesion.  It was found that participation in conflict prevention in society is in a low category. Enhancing public engagement in conflict prevention needs the immediate implementation of EWS for social conflict early detection through public involvement.  The Android application particularly WhatsApp group can be used to create EWS at the village level at a low cost. Village leaders who serve to assess the village's vulnerability level can be involved in this process.   Finally, all stakeholders can use the study's findings as a basis for developing policies related to the use of WhatsApp to reduce disputes in places susceptible to conflict.
Validation of cyber security behaviour among adolescents at Malaysia university: Revisiting gender as a role
Authors: Ting Tin Tin , Cheah Kar Man , Khiew Jie Xin , Lee Yung Chin , Chaw Jun Kit , Teoh Chong Keat
Published: January 2024

Cyber-attacks and crimes are still a problem in Malaysia. COVID-19 has pushed Malaysians into the digital world more quickly. These cyberattacks may rise and affect more people. Thus, the aim of this study is to find out if there is a significant difference in the level of cyber security behaviour between males and females in the aspects of malware, password usage, phishing, social engineering and online scamming in Malaysia. An online questionnaire survey was used to gather data from Malaysia and received 207 total responses. Cronbach's alpha is used to measure questionnaire items' reliability. A t-test is used to determine the differences between male and female cyber security behaviour. The results show that there is no significant difference between males and females in four aspects out of five, which are malware, password usage, phishing and social engineering. There is a significant difference between males and females in the aspect of online scams. This research helps those who formulate education policies by determining that there is no noticeable gender difference. Men should get the same level of education and training as women. The findings also demonstrate that women's awareness of technology is increasing.
PENGARUH EMPLOYER ATTRACTIVENESS DAN KOMPENSASI TERHADAP MINAT MELAMAR PEKERJAAN
Authors: Sinaga Margaretha Noprisda , Pramudita Dismas Persada Dewangga
Published: January 2024

Companies are currently competing to be superior so they can survive in an increasingly hypercompetitive market. High-quality human resources are an important factor that potentially support companies to become superior. A recruitment process that runs well will produce quality human resources. Effective recruitment can be carried out when recruitment sources can be filtered well. Therefore, this research aims to determine the influence of employer attractiveness and compensation on interest in applying for jobs. The respondents in this research were 50 Atma Jaya University Yogyakarta students, Class of 2019. Data collection in this research was carried out by distributing questionnaires online. The data that has been obtained is processed using multiple linear analysis techniques with the help of SPSS 29 software. The results of this research show that employer attractiveness and compensation have a positive and significant effect on interest in applying for jobs.