bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensitivity analysis and noise reduction optimization design of the insert-pipe double expansion chamber muffler
Authors: Zhang Liang , Li Li , Zhuang Zhuo
Published: September 2023

The insert-pipe double expansion chamber muffler has less passbands and higher sound attenuation in the plane wave range, which is widely used to reduce noise of industrial equipment. But there are many parameters that affect the transmission loss of the insert-pipe double expansion chamber muffler, and the sensitivity of each factor is not clear. Identifying the most influential factor among numerous parameters is an important challenge. It is necessary to investigate the sensitivity of all parameters and study parameter optimization algorithms. Based on the method of transfer matrix analysis, this paper studies the insert-pipe double expansion chamber muffler and its sound elimination mechanism. The global sensitivity analysis of the transmission loss of insert-pipe double expansion chamber muffler was conducted using Sobol's method, and the influence of each parameter sensitivity was examined. According to the noise characteristics of an air conditioner compressor, the external penalty function method (EPFM) algorithm is used to optimize the insert-pipe double expansion chamber muffler, and the maximum transmission loss is obtained in a specific frequency band. According to the optimized parameters, the muffler is designed, manufactured, and installed in a pipeline system to carry out a noise experiment to verify the effectiveness of the optimization scheme.
Does work have a future? The need for new meanings and new valuings of work
Authors: Deranty Jean-Philippe , Rhodes Carl , Yeoman Ruth
Published: September 2023

This introduction to the special section “Does Work Have a Future?” begins by reviewing the main ways work stands at the crossroads today. We identify three core disputes with the potential to disrupt the future of work but which also harbor resources for affirmative futures of work: the precariousness of work and lives under existing economic arrangements; the emergence of care work as a source of social and environmental value; and technological change. We then consider the demands for new meanings and new valuings that the manifold disputed status of work formulates. Finally, we highlight the contributions the four pieces making up this special section give to that momentous question of whether work has a future.
Memetic logics of participation: Fitness body culture on Instagram
Authors: Schöps Jonathan David , Schwarz Sarah , Rojkowski Veronika
Published: September 2023

This study examines participatory logics as a process of the platformization of culture in the context of fitness body culture on Instagram. Building upon meme theory and applying a networked content analysis of #fitness, we highlight the memetic logics of participation that manifest in and derive from an interplay between consumers and affordances. Our findings, first, detail how content exhibiting common characteristics forms contextual memes that make up the platform's meme complex of fitness body culture. We, second, outline how the memetic logics of participation interconnect, cross-reference, and reinforce a standardized and platformized consumer culture. This study ultimately points to a networked public in which consumers follow both context-specific and platform-afforded—memetic—logics of participation in cultural production.
The Elevator Technique: A New Bailout Maneuver to Achieve Target Vessel Patency During Challenging BEVAR
Authors: Lerisson Erol , Le Houérou Thomas , Rockley Mark , Gaudin Antoine , Costanzo Alessandro , Fabre Dominique , Haulon Stéphan
Published: September 2023

Purpose:

The purpose of the study is to describe a new bailout maneuver for use during branched endovascular thoracoabdominal aneurysm repair (BEVAR) while dealing with challenging target vessel cannulation.

Technique:

A 54-year-old woman underwent urgent BEVAR with a low-profile T-branch device to exclude a type 2 thoracoabdominal aneurysm (TAAA). The endovascular procedure was challenging because the left renal artery ostium was covered by the endograft fabric, compounded by diseased target vessels. A novel bailout maneuver is described. After angioplasty of the left renal artery (LRA), the LRA remained precannulated and a low-profile T-branch was implanted. The 3 proximal branches (superior mesenteric artery, inferior mesenteric artery, and the right renal artery) were connected to their respective target vessels swiftly with a steerable sheath from a femoral approach. Access to the left renal artery was not achieved because it was obstructed by the fully deployed endograft. We subsequently stented the LRA over the “pre-positioned buddy wire,” using a balloon-expandable covered stent protruding inside the aneurysm lumen. The proximal stent was then flared and lifted upward using an 8.5 Fr steerable sheath, which made cannulation and stenting of the LRA through the side-branch from above finally achievable.

Conclusion:

The elevator technique described in this article will help achieve technical success in challenging BEVAR cases.

Clinical Impact

We describe in this technical note the “elevator technique” that will complement the “Snare-Ride” and “Balloon Anchoring” techniques over a buddy wire positioned in a target vessel, to provide successful bailout options for challenging TV cannulations during BEVAR.After failed access to the renal artery through the renal branch, a covered stent was implanted in the renal artery over the buddy wire with 10 mm protruding into the aortic lumen. This stent was then flared, prior to advancing a curved steerable sheath into the stent, which shaped it with a superior-facing funneled aortic segment. This maneuver resulted in the renal stent facing its corresponding branch, finally easy to access from the endograft lumen.
Mechanisms of acupuncture–electroacupuncture on inflammatory pain
Authors: Zhang Qingxiang , Zhou Mengmeng , Huo Mingzhu , Si Yuxin , Zhang Youlin , Fang Yuxin , Zhang Di
Published: September 2023

Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And 16 of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.
The neutral condition in conflict tasks: On the violation of the midpoint assumption in reaction time trends
Authors: Smith Parker , Ulrich Rolf
Published: September 2023

Although the relation between congruent and incongruent conditions in conflict tasks has been the primary focus of cognitive control studies, the neutral condition is often set as a baseline directly between the two conditions. However, empirical evidence suggests that the average neutral reaction time (RT) is not placed evenly between the two opposing conditions. This article set out to establish two things: First, to reinforce the informative nature of the neutral condition and second, to highlight how it can be useful for modelling. We explored how RT in the neutral condition of conflict tasks (Stroop, Flanker, and Simon Tasks) deviated from the predictions of current diffusion models. Current diffusion models of conflict tasks predict a neutral RT that is the average of the congruent and incongruent RT, called the midpoint assumption. To investigate this, we first conducted a cursory limited search that recorded the average RT’s of conflict tasks with neutral conditions. Upon finding evidence of a midpoint assumption violation which showed a larger disparity between average neutral and incongruent RT, we tested the previously mentioned conflict tasks with two different sets of stimuli to establish the robustness of the effect. The midpoint assumption violation is sometimes inconsistent with the prediction of diffusion models of conflict processing (e.g., the Diffusion Model of Conflict), suggesting possible elaborations of such models.
Association between radioulnar impingement and salvage surgical procedures of the distal radioulnar joint: influence of confounding variables
Authors: Hernández-Cortés Pedro , Catena Andrés , Hernández-Peregrina Pedro , Elizondo-Espósito Diana , Pajares-López Miguel , Rosales Roberto S.
Published: September 2023

We conducted an ambispective cohort study to assess the association between symptomatic radioulnar impingement syndrome (SRUIS) and distal radioulnar joint (DRUJ) salvage surgery to examine the influence of confounders on the final effect. The outcome variable was the incidence of SRUIS and the exposure variable was the surgical procedure. Seventy-two patients with median age of 48 years (IQR 25–78) were examined using bivariate and logistic regression multivariate analyses, and confounders were analysed in 15 multivariate models. Overall, SRUIS occurred in 21 patients (29%). Bivariate analysis showed a significant association between SRUIS and type of surgical procedure, observed in 71% after Sauvé–Kapandji, 50% after Bowers and 15% after Darrach procedure. When adjusted for age, aetiology and previous surgery, the significant association disappeared. Confounding is an important factor when accounting for SRUIS after DRUJ salvage surgery. The risk of SRUIS did not depend on the procedure, but rather on patient’s age, aetiology and previous surgery.

Level of evidence: II
Regenerative medicine for early osteoarthritis
Authors: Im Gun-Il , Henrotin Yves
Published: September 2023

The concept of early osteoarthritis (OA) is based on the expectation that if found and treated in the early stage, the progression of the disease might be arrested before affected joints are irreversibly destroyed. This notion of early OA detection can also bear meaning for regenerative medicine (RM) which is purposed to cure a disease by regenerating the damaged tissue. RM can be a category of disease-modifying osteoarthritis drugs (DMOADs) and provide an attractive treatment for OA, restoring structural damage incurred during the disease by repopulating cells and reconstituting. While cell therapy including the use of stem cells is conflated with RM, it may also comprise gene therapy, exosomes, and other cell or cell-free-derived products. Considering that not all early OA will become advanced OA and that RM has a characteristic of personalized medicine, it would be very important to foretell, even roughly, which patients will progress rapidly and who will favorably respond to regenerative treatment. Subclassification and comprehensive endotyping or phenotyping (E/P) can be very helpful in detecting the population who would benefit from RM as well as rapid progressors who need closer monitoring.
Risks of Increased Operative Time and Longer Hospital Stays Based on Age in Total Ankle Arthroplasty
Authors: Peairs Emily M. , Anastasio Albert T. , Kim Billy , Walley Kempland , Adams Samuel B.
Published: September 2023

Background

As total ankle arthroplasty (TAA) is increasingly performed in younger individuals in the United States, the aim of this study was to analyze TAA outcomes and complications by age.

Methods

A total of 1619 primary and revision TAAs from 2012 to 2020 were collected and included from the National Surgical Quality Improvement Program. Patients were stratified by age into those younger than 55 years, between 55 and 70 years, and older than 70 years. Demographics, medical comorbidities, American Society of Anesthesiology Physical Classification (ASA) class, operative time, 30-day complications, and comorbid conditions were compared by univariable analysis. Multivariable analysis was used to analyze readmission rates, reoperation rates, operative time, and hospital length of stay.

Results

Patients younger than 55 years were found to have a significantly longer operative time compared to patients older than 70 years of age or between 55 and 70 years (P < .001, P = .034). Patients older than 70 years were found to have a significantly longer hospital stay (P < .001) and a greater risk of discharging to a nonhome location (P < .001). By multivariable analysis, patients 55 to 70 have a statistically lower risk of readmission compared to the other 2 cohorts (P = .043). No difference in postoperative complications was demonstrated between the different groups.

Conclusions

As the incidence of total ankle arthroplasty increases across all ages, it is important to understand specific perioperative risks for each age group. Younger patients tended to have longer surgeries and higher body mass indexes (BMIs). Patients aged 55 to 70 years had the lowest risks for perioperative complications. Patients greater than 70 years were at risk for longer hospital stays and discharge to nonhome locations. There were no differences in postoperative complications by age.

Level of Evidence:

Level III: Retrospective comparative study
Parakinesia Brachialis Oscitans and Excessive yawning From Tumefactive Demyelination
Authors: Tsai Chia-Chen , Lee Joshua D , Chen Tychicus
Published: September 2023

We present a case and video of a 31-year-old man with biopsy-confirmed tumefactive demyelination affecting the right internal capsule causing left hemiplegia, excessive yawning, and the curious but well-described phenomenon of parakinesia brachialis oscitans (PBO) with transient tonic elevation of his paralyzed arm while yawning. PBO is most commonly reported in ischemic stroke with internal capsule or pontomedullary brainstem lesions. Our case uniquely demonstrates this phenomenon in the case of tumefactive demyelination. We also highlight excessive yawning which has also been described in multiple sclerosis.
Racial and religious motives for drug criminalization
Authors: Johnstad Petter Grahl
Published: September 2023

The world has a long-standing system of drug control intended to suppress the use of a range of psychoactive drugs on the basis that such use is very harmful both to the users themselves and to their social surroundings. This perception of harmfulness has a long medical history, but recent research indicates that many forms of illicit drug use are not more harmful than the use of alcohol and tobacco. This article analyzes the historical and normative background for the apparently exaggerated assessments of drug harms on which the regime of drug control is founded. Starting from the observation that the drugs that have been exempted from this criminalization regime are those that were integrated in European cultures during the early modern era whereas the drugs criminalized under this regime lack such a history of European acceptance, the article discusses racial and cultural (especially religious) prejudice as a foundation for the exaggerated perceptions of drug harms. It finds that such prejudice is well-attested in the historical literature and seems to have contributed substantially to the formation of the international drug control regime. In sum, this article argues that drug prohibition was first introduced in the early modern era on racial and religious grounds and that the influence of these prohibition motives can be traced, directly and indirectly, all the way to the present day. This influence may explain why the health risks associated with illicit drug use are still often exaggerated in contemporary drug harms research.
China’s digital infrastructure: Networks, systems, standards
Authors: de Seta Gabriele
Published: September 2023

In the People’s Republic of China, the development of information infrastructures has been a cardinal component of the national modernization project for more than four decades. While most discussions of digital infrastructure in the country focus on the ‘Chinese internet,' framed by architectures of control like the Great Firewall and governmental initiatives like Internet Plus, this special issue contends that China’s digital infrastructure extends from the physical cables laid under urban streets to the ideological capture of surveillance systems, and from the smart home devices domesticated by elderly citizens to the QR codes plastered on everyday life surfaces. Through their interdisciplinary and innovative studies, this issue’s contributors push discussions of China’s digital infrastructure beyond the reduction to authoritarian control and the triumphal rhetorics of governmental imaginaries. Given the breadth of analytical scale and the variety of research methods featured in this collection, the nine contributions to this special issue are organized in three clusters, each centered around one of three key terms from infrastructure studies: networks, systems, and standards. By accounting for heterogeneous scales and relationships through which China’s digital infrastructure emerges, consolidates, and falls apart, these articles produce original knowledge about complex sociotechnical processes and develop productive concepts for future scholarship.
Displaced Geriatric Femoral Neck Fractures: A Retrospective Comparison of Total Hip Arthroplasties Versus Hemiarthroplasty
Authors: Morgan Steven , Jarvis Stephanie , Conti Alexander , Staudinger Kelsey , Reynolds Cassandra , Bar-Or David
Published: September 2023

Introduction

Controversary exists around the best surgical management for traumatic geriatric displaced femoral neck fractures. The study objective was to compare outcomes among those managed with a total hip arthroplasty (THA) to those managed with a hemiarthroplasty (HA).

Methods

This retrospective matched cohort study included geriatric hip fractures (≥65 y/o) admitted 7/1/16-3/31/20. Patients were matched on having an advanced directive, pre-existing dementia, and age. Outcomes included: time to surgery, length of stay (LOS), blood loss volume, and discharge destination. THAs were compared to HAs; an alpha of <.05 indicated statistical significance.

Results

There were 191 patients: 86% were treated with HA and 14% with THA. Most (40%) were 80-89 years old, 66% were female, and 92% were white. After matching, the groups were well balanced on demographics and baseline characteristics with 27 patients/arm. The median time to surgery was 23 hours for both arms, P = .38. The LOS was significantly longer for those managed with a HA when compared to those managed with a THA, 5.6 vs 4.0 days, P = .001. The median blood loss volume was significantly lower for HAs than for THAs, but the difference was small, 100 vs 120 mL, P = .02. Patients managed with a HA were less likely to be discharged home than those managed with a THA, 22% vs 70%, P = .005.

Conclusions

While patients managed with a THA had significantly more blood loss than those managed with a HA, the difference in blood loss was small and not clinically relevant. Those managed with a THA experienced a significantly shorter LOS and were more likely to be discharged home than patients managed with a HA. Among a healthier, younger geriatric population, THA may lead to shortened LOS and improved discharge destinations when compared to HA for treatment of femoral neck fractures.
Public Procurement, Land Ownership and Agricultural Price Variation Across States: The Case of Paddy Cultivation in India
Authors: Thakur Avanindra Nath
Published: September 2023

The markets for agricultural crops have always been segmented. Although agricultural price policy in India is largely focused on declaring minimum support price (MSP), for select crops at all Indian levels the price for any crop has hardly been unique for the country. In this context, the paper tries to understand how far prices of paddy have been different across states. To what extent such price policies, primarily the public procurement system, are instrumental in the determination of actual price differentials realized by farmers across states. The paper draws its analysis from unit-level data of the 77th round of the National Sample Survey on the situation assessment of farmers (2018–2019). The paper evaluates some of the possible factors such as government procurements of paddy, land ownership patterns, percentage of farmers selling in the regulated markets, among others, in the context of price determination of paddy. The paper also seeks the link between local market price and average price in the regulated markets in different states.
Cavitation Diagnostics Based on Self-Tuning VMD for Fluid Machinery with Low-SNR Conditions
Authors: Liu Hao , Tong Zheming , Shang Bingyang , Tong Shuiguang
Published: September 2023

Variational mode decomposition (VMD) is a suitable tool for processing cavitation-induced vibration signals and is greatly affected by two parameters: the decomposed number K and penalty factor α under strong noise interference. To solve this issue, this study proposed self-tuning VMD (SVMD) for cavitation diagnostics in fluid machinery, with a special focus on low signal-to-noise ratio conditions. A two-stage progressive refinement of the coarsely located target penalty factor for SVMD was conducted to narrow down the search space for accelerated decomposition. A hybrid optimized sparrow search algorithm (HOSSA) was developed for optimal α fine-tuning in a refined space based on fault-type-guided objective functions. Based on the submodes obtained using exclusive penalty factors in each iteration, the cavitation-related characteristic frequencies (CCFs) were extracted for diagnostics. The power spectrum correlation coefficient between the SVMD reconstruction and original signals was employed as a stop criterion to determine whether to stop further decomposition. The proposed SVMD overcomes the blindness of setting the mode number K in advance and the drawback of sharing penalty factors for all submodes in fixed-parameter and parameter-optimized VMDs. Comparisons with other existing methods in simulation signal decomposition and in-lab experimental data demonstrated the advantages of the proposed method in accurately extracting CCFs with lower computational cost. SVMD especially enhances the denoising capability of the VMD-based method.
Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages
Authors: Nascimento Camila Sales , Tavares Naiara Clemente , Batista Izabella Cristina Andrade , Caetano Mônica Maria Magalhães , de Oliveira Eneida Santos , Colombarolli Stella Garcia , Lage Anna Carolina Pinheiro , Corrêa-Oliveira Rodrigo , Alves Érica Alessandra Rocha , de Melo Celso Pinto , Calzavara-Silva Carlos Eduardo
Published: September 2023

Background

Breast cancer is the neoplastic disease with the highest incidence and mortality in the female population worldwide. Treatment remains challenging due to various factors. Therefore, it is of great importance to develop new therapeutic strategies that promote the safe destruction of neoplastic cells without compromising patients' quality of life. Among advances in the treatment of breast cancer, immunotherapy stands out as a promising trend. Recent studies have demonstrated the potential of iron oxide nanoparticles in promoting the reprogramming of M2 macrophages (pro-tumor phenotype) into M1 macrophages (anti-tumor phenotype) within the tumor microenvironment, resulting in potent antitumor effects. In this study, the effect of polyaniline-coated iron oxide nanoparticles (Pani/y-Fe2O3) on macrophage polarization and breast cancer cell death was investigated.

Methods

The non-cytotoxic concentration of nanoparticles was determined using the MTT assay. For in vitro co-culture experiments, breast cancer cell lines MCF -7 and MDA-MB -231 and macrophages THP-1 were co-cultured in a Transwell system and then the effects of Pani/y-Fe2O3 on cell viability, gene expression, cytokine profile, and oxidative stress markers were investigated.

Results

The results showed that Pani/y-Fe2O3 nanoparticles induced M2-to-M1 macrophage polarization in both cell lines through different pathways. In MCF -7 and THP-1 macrophage co-culture, the study showed a decrease in cytokine levels IL -1β, upregulation of M1-associated genes (IL-12, TNF-α) in macrophages, resulting in increased MCF -7 cell death by apoptosis (caspase 3/7+). In MDA-MB -231 co-cultures, increases in cytokines IL -6, IL -1β, and oxidative stress markers were observed, as well as upregulation of the inducible nitric oxide synthase (iNOS) gene in macrophages, leading to tumor cell death via apoptosis-independent pathways (Sytox+).

Conclusions

These findings highlight the potential of Pani/y-Fe2O3 as a promising therapeutic approach in the context of breast cancer treatment by effectively reprogramming M2 macrophages into an anti-tumor M1 phenotype, Pani/y-Fe2O3 nanoparticles demonstrated the ability to elicit antitumor effects in both MCF-7 and MDA-MB-231 breast cancer cell lines.
Assessment of beneficial effects and identification of host adaptation-associated genes of Ligilactobacillus salivarius isolated from badgers
Authors: Wang Yu , Xu Xiaomeng , Chen Huan , Yang Fang , Xu Bo , Wang Kun , Liu Qianwen , Liang Guixin , Zhang Ruiqi , Jiao Xin’an , Zhang Yunzeng
Published: September 2023

Background

Ligilactobacillus salivarius has been frequently isolated from the gut microbiota of humans and domesticated animals and has been studied as a candidate probiotic. Badger (Meles meles) is known as a “generalist” species that consumes complex foods and exhibits tolerance and resistance to certain pathogens, which can be partly attributed to the beneficial microbes such as L. salivarius in the gut microbiota. However, our understanding of the beneficial traits and genomic features of badger-originated L. salivarius remains elusive.

Results

In this study, nine L. salivarius strains were isolated from wild badgers' feces, one of which exhibited good probiotic properties. Complete genomes of the nine L. salivarius strains were generated, and comparative genomic analysis was performed with the publicly available complete genomes of L. salivarius obtained from humans and domesticated animals. The strains originating from badgers harbored a larger genome, a higher number of protein-coding sequences, and functionally annotated genes than those originating from humans and chickens. The pan-genome phylogenetic tree demonstrated that the strains originating from badgers formed a separate clade, and totally 412 gene families (12.6% of the total gene families in the pan-genome) were identified as genes gained by the last common ancestor of the badger group. The badger group harbored significantly more gene families responsible for the degradation of complex carbohydrate substrates and production of polysaccharides than strains from other hosts; many of these were acquired by gene gain events.

Conclusions

A candidate probiotic and nine L. salivarius complete genomes were obtained from the badgers’ gut microbiome, and several beneficial genes were identified to be specifically present in the badger-originated strains that were gained in the evolution. Our study provides novel insights into the adaptation of L. salivarius to the intestinal habitat of wild badgers and provides valuable strain and genome resources for the development of L. salivarius as a probiotic.
Quantitative trait loci and candidate genes for yield-related traits of upland cotton revealed by genome-wide association analysis under drought conditions
Authors: Sun Fenglei , Yang Yanlong , Wang Penglong , Ma Jun , Du Xiongming
Published: September 2023

Background

Due to the influence of extreme weather, the environment in China’s main cotton-producing areas is prone to drought stress conditions, which affect the growth and development of cotton and lead to a decrease in cotton yield.

Results

In this study, 188 upland cotton germplasm resources were phenotyped for data of 8 traits (including 3 major yield traits) under drought conditions in three environments for two consecutive years. Correlation analysis revealed significant positive correlations between the three yield traits. Genetic analysis showed that the estimated heritability of the seed cotton index (SC) under drought conditions was the highest (80.81%), followed by that of boll weight (BW) (80.64%) and the lint cotton index (LC) (70.49%) With genome-wide association study (GWAS) analysis, a total of 75 quantitative trait loci (QTLs) were identified, including two highly credible new QTL hotspots. Three candidate genes (Gh_D09G064400,Gh_D10G261000andGh_D10G254000) located in the two new QTL hotspots, QTL51 and QTL55, were highly expressed in the early stage of fiber development and showed significant correlations with SC, LC and BW. The expression of three candidate genes in two extreme materials after drought stress was analyzed by qRT-PCR, and the expression of these two materials in fibers at 15, 20 and 25 DPA. The expression of these three candidate genes was significantly upregulated after drought stress and was significantly higher in drought-tolerant materials than in drought-sensitive materials. In addition, the expression levels of the three candidate genes were higher in the early stage of fiber development (15 DPA), and the expression levels in drought-tolerant germplasm were higher than those in drought-sensitive germplasm. These three candidate genes may play an important role in determining cotton yield under drought conditions.

Conclusions

This study is helpful for understanding the regulatory genes affecting cotton yield under drought conditions and provides germplasm and candidate gene resources for breeding high-yield cotton varieties under these conditions.
Utilizing hydrothermal time models to assess the effects of temperature and osmotic stress on maize (Zea mays L.) germination and physiological responses
Authors: Khan Waqif , Shah Sumbal , Ullah Abd , Ullah Sami , Amin Fazal , Iqbal Babar , Ahmad Naveed , Abdel-Maksoud Mostafa A. , Okla Mohammed k. , El-Zaidy Mohamed , Al-Qahtani Wahidah H. , Fahad Shah
Published: September 2023

The application of germination models in economic crop management makes them extremely useful for predicting seed germination. Hence, we examined the effect of varying water potentials (Ψs; 0. − 0.3, − 0.6, − 0.9, − 1.2 MPa) and temperatures (Ts; 20, 25, 30, 35, 40 °C) on maize germination and enzymatic antioxidant mechanism. We observed that varying Ts and Ψs significantly influenced germination percentage (GP) and germination rate (GR), and other germination parameters, including germination rate index (GRI), germination index (GI), mean germination index (MGI), mean germination time (MGT), coefficient of the velocity of germination (CVG), and germination energy (GE) (p ≤ 0.01). Maximum (87.60) and minimum (55.20) hydro-time constant (θH) were reported at 35 °C and 20 °C, respectively. In addition, base water potential at 50 percentiles was highest at 30 °C (15.84 MPa) and lowest at 20 °C (15.46 MPa). Furthermore, the optimal, low, and ceiling T (To, Tb and Tc, respectively) were determined as 30 °C, 20 °C and 40 °C, respectively. The highest θT1 and θT2 were reported at 40 °C (0 MPa) and 20 °C (− 0.9 MPa), respectively. HTT has a higher value (R2 = 0.43 at 40 °C) at sub-optimal than supra-optimal temperatures (R2 = 0.41 at 40 °C). Antioxidant enzymes, including peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), ascorbate peroxidase (APX), and glutathione peroxidase (GPX), increased with decreasing Ψs. In contrast, CAT and POD were higher at 20 °C and 40 °C but declined at 25, 30, and 35 °C. The APX and GPX remained unchanged at 20, 25, 30, and 40 °C but declined at 35 °C. Thus, maintaining enzymatic activity is a protective mechanism against oxidative stress. A decline in germination characteristics may result from energy diverting to anti-stress tools (antioxidant enzymes) necessary for eliminating reactive oxygen species (ROS) to reduce salinity-induced oxidative damage. The parameters examined in this study are easily applicable to simulation models of Z. mays L. germination under extreme environmental conditions characterized by water deficits and temperature fluctuations.
Correlation of serum complement factor 5a level with inflammatory response and cognitive function in patients with Alzheimer’s disease of different severity
Authors: Li Zhilian , Wu Huifang , Luo Yi , Tan Xianpei
Published: September 2023

Background

Alzheimer’s disease (AD) is a common cause of dementia. Serum complement factor 5a (C5a) is exceedingly implicated in AD. We explored the role of C5a levels in AD patients of different severity.

Methods

Mild, moderate, and severe AD patients, and healthy controls were included. C5a and pro-inflammatory factor (TNF-α, IL-1β, IL-6, CRP) levels were assessed by ELISA, and cognitive function was evaluated by Mini-Mental state examination (MMSE) score. The correlations between C5a, inflammatory factor levels, MMSE score, and plasma Aβ42/Aβ40 ratio were analyzed by Pearson tests. Independent risk factors for AD aggravation were assessed by logistic multivariate regression analysis. According to the cut-off value of receiver operating characteristic (ROC) curve analysis of C5a level, AD patients were assigned into low/high expression groups, and severe AD incidence was compared. Severe AD cumulative incidence was analyzed by Kaplan-Meier curve.

Results

Serum C5a, TNF-α, IL-1β, IL-6 and CRP levels were raised, and MMSE score was lowered in AD. Serum C5a, TNF-α, IL-1β, IL-6 and CRP levels in severe AD patients were higher than those in mild/moderate AD patients, but there were no significant differences in these cytokines between moderate and mild AD groups. The MMSE score of severe AD patients was lower than that of mild/moderate AD patients. Serum C5a level was positively correlated with serum TNF-α, IL-1β, IL-6, and CRP levels, and negatively correlated with MMSE score, with no obvious correlation with plasma Aβ42/Aβ40 ratio. Serum C5a level was one of the independent risk factors for AD aggravation. The occurrence of severe AD might be related to an increase in serum C5a level.

Conclusion

Serum C5a level increased with AD severity, and its expression was positively correlated with serum pro-inflammatory factor levels, and negatively correlated with cognitive function.
Effects of blended learning training for oncology physicians to advise their patients about complementary and integrative therapies: results from the multicenter cluster-randomized KOKON-KTO trial
Authors: Helmer Stefanie M. , Rogge Alizé A. , King Ryan , Canella Claudia , Pach Daniel , Witt Claudia M.
Published: September 2023

Background

Many oncology physicians are confronted with the topic of complementary and integrative medicine (CIM) by cancer patients. This study examined whether a blended learning (e-learning and a workshop) to train oncology physicians in providing advice on CIM therapies to their cancer patients, in addition to distributing an information leaflet about reputable CIM websites, had different effects on physician-reported outcomes in regard to consultations compared with only distributing the leaflet.

Methods

In a multicenter, cluster-randomized trial, 48 oncology physicians were randomly allocated to an intervention group (CIM consultation and an information leaflet) or a control group (information leaflet only). After the training, the oncology physicians conducted 297 consultations with their cancer patients. Measurements were assessed at oncology physician, physician–patient-interaction (measured by external reviewers), and patient levels. This analysis focused on the physician outcomes of stress reaction and perceived consultation skill competency. In addition, qualitative interviews were conducted with a subsample of oncology physicians who experienced both, the intervention and control condition.

Results

The oncology physicians in the intervention group showed a lower stress reaction in all measured dimensions after CIM consultations than those in the control group. There was no significant difference between oncology physicians in the intervention and control groups regarding the perceived consultation skill competency (overburden: intervention 1.4 [95% CI: 0.7;2.1]; control 2.1 [95% CI: 1.4;2.7], tension: 1.3 [95% CI: 0.7;2.0] vs. 1.9 [95% CI: 1.3;2.5], and discomfort with consultation situations: 1.0 [95% CI: 0.4;1.7]; vs. 1.7 [95% CI: 1.2;2.3]). The qualitative data showed that only providing the leaflet seemed impersonal to oncology physicians, while the training made them feel well prepared to conduct a full conversation about CIM and provide the information leaflet.

Conclusions

In our exploratory study providing structured CIM consultations showed positive effects on the perceived stress of oncology physicians, and the training was subjectively experienced as an approach that improved physician preparation for advising cancer patients about CIM, however no effects regarding perceived consultation skill competency were found.

Trial registration

The trial registration number of the KOKON-KTO study is DRKS00012704 in the German Clinical Trials Register (Date of registration: 28.08.2017).
Posterior urethral valve in thai boys
Authors: Ekarat Prakorn , Attawettayanon Worapat , Limratchapong Chompoonut , Sophark Praewa , Vachvanichsanong Prayong
Published: September 2023

Background

Posterior urethral valve (PUV) is the most common congenital bladder outlet obstruction in boys, causing renal damage beginning in utero. There are scarce data from Thailand regarding the long-term outcomes of PUV in boys, thus the aim of this study was to examine the presentation, clinical course, complications, outcomes and renal survival in PUV boys.

Methods

We reviewed the medical records of PUV boys treated at the Pediatric Nephrology Clinic, Prince of Songkla University, Thailand, over a 30-year-period.

Results

Seventy-seven PUV boys were identified, with a median age at diagnosis of 4.8 months. The most common presentations were urinary tract infection (UTI), poor urine stream and urinary dribbling in 26 (33.8%), 19 (24.7%) and 11 (14.3%) boys, respectively. Renal ultrasound results in 70 boys showed 8 (11.4%) unilateral and 56 (80%) bilateral hydronephroses. Of 72 voiding cystourethrograms, 18 (25.0%) showed unilateral and 22 (30.6%) bilateral vesicoureteral refluxes. 99mTc dimercaptosuccinic acid renal scans in 30 boys showed 12 (40%) unilateral and 8 (26.7%) bilateral renal damage. Fifty-nine (76.6%) boys had 149 UTIs; 42 (54.4%) had recurrent UTI. Forty-eight boys had valve ablation at the median age of 30.3 months. 22 boys (28.6%) developed chronic kidney disease (CKD) at a median age of 15.0 years.

Conclusion

Of 77 PUV Thai boys, UTI was the most common presentation. Recurrence of UTI and CKD was the most common consequence. Lifelong follow-up for renal and bladder functions is essential for all PUV patients.
Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy
Authors: Hjell Gabriela , Rokicki Jaroslav , Szabo Attila , Holst René , Tesli Natalia , Bell Christina , Fischer-Vieler Thomas , Werner Maren Caroline Frogner , Lunding Synve Hoffart , Ormerod Monica Bettina Elkjær Greenwood , Johansen Ingrid Torp , Djurovic Srdjan , Ueland Thor , Andreassen Ole Andreas , Melle Ingrid , Lagerberg Trine Vik , Mørch-Johnsen Lynn , Steen Nils Eiel , Haukvik Unn Kristin
Published: September 2023

Background

Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of immune dysregulation has been indicated, and the effects of psychopharmacological agents vary. We investigated if impulsivity was associated with circulating immune marker levels and with a range of psychopharmacological treatment regimens in severe mental disorders.

Methods

Impulsivity was assessed in a sample (N = 657) of patients with schizophrenia or schizophreniform disorder (SCZ) (N = 116) or bipolar disorder (BD) (N = 159) and healthy participants (N = 382) using the Barratt Impulsiveness Scale (BIS-11) questionnaire. Plasma levels of systemic immune markers (RANTES, IL-1RA, IL-18, IL-18BP, sTNFR-1) were measured by enzyme immunoassays. Patients underwent thorough clinical assessment, including evaluation of psychotropic medication. Associations were assessed using linear regressions.

Results

Impulsivity  was positively associated with SCZ (p < 0.001) and BD (p < 0.001) diagnosis and negatively associated with age (p < 0.05), but not significantly associated with any of the circulating immune markers independently of diagnostic status. Among patients, impulsivity was negatively associated with lithium treatment (p = 0.003) and positively associated with antidepressant treatment (p = 0.011) after controlling for diagnosis, psychotropic co-medications, manic symptoms, and depressive symptoms.

Conclusions

We report elevated impulsivity across SCZ and BD but no associations to systemic immune dysregulation based on the current immune marker selection. The present study reveals associations between impulsivity in severe mental disorders and treatment with lithium and antidepressants, with opposite directions. Future studies are warranted to determine the causal directionality of the observed associations with psychopharmacotherapy.
An exploration of suicidal ideation and attempts, and care use and unmet need among suicide-ideators in a Belgian population study
Authors: Rens Eva , Portzky Gwendolyn , Morrens Manuel , Dom Geert , Van den Broeck Kris , Gijzen Mandy
Published: September 2023

Background

Suicidal ideation, or thinking about death and suicide, is common across all layers of society. The aim of this paper is to add to the understanding of suicidal ideation in the general population, as well as help-seeking behaviors and perceived unmet mental health needs among those who report suicidal thoughts.

Methods

The research is part of a representative population-based survey study of mental wellbeing in Antwerp (Flanders, Belgium) carried out in 2021. A total of 1202 participants between 15 and 80 years old answered the Ask Suicide-Screening Questions (ASQ), and an additional question about suicide plans. Participation was by invitation only and possible online or via a postal paper questionnaire. Univariate and multivariate logistic regression analyses were used to explore the association between both current suicidal ideation and self-reported lifetime suicide attempt with the sociodemographic factors age, gender, educational level, origin and financial distress. Moreover, formal care use for mental health was examined among those experiencing suicidal ideation, and logistic regression analyses were used to assess associated sociodemographic factors. Finally, perceived unmet mental health needs were assessed among suicide ideators.

Results

The point-prevalence of suicidal ideation was 8.6% and was higher among younger age groups and individuals reporting financial distress. The lifetime-prevalence of suicide attempts is 6.5% and was higher in younger people and individuals with a primary educational level and with financial distress. About half (45.6%) of those with suicidal ideation consulted a professional for mental health problems in the past twelve months. Men and those with a primary educational level were less likely to seek help. Half of suicide ideators without care use perceived some need for mental health care, and a third of suicide ideators who used care perceived the obtained help as insufficient, resulting in a population prevalence of 3.6% suicide ideators with a fully or partially perceived unmet need.

Conclusions

The prevalence of suicide attempts, suicidal ideation and unmet needs among suicide-ideators is high in this Belgian sample. Mental health care need perception in suicide ideators needs further investigation.
Flexible delivery of opioid agonist treatment during COVID-19 in Norway: qualitative and quantitative findings from an online survey of provider experiences
Authors: McDonald Rebecca , Bech Anne Berit , Clausen Thomas
Published: September 2023

Background

For patients receiving daily opioid agonist treatment (OAT) for opioid dependence, several countries relaxed treatment guidelines at the beginning of the COVID-19 pandemic. This involved longer take-home intervals for methadone and buprenorphine doses as well as a reduction in supervised dosing and drug screening. To date, little is known about the medium or long-term experience of OAT deregulation. Therefore, we conducted a survey to explore how OAT providers perceived greater flexibility in OAT service delivery at the end of the second year of the pandemic.

Methods

Nationwide cross-sectional study of twenty-three OAT units in 19 publicly funded hospital trusts in Norway. OAT units were sent a 29-item online questionnaire comprising closed-format and open-ended questions on treatment provider experiences and changes in OAT service delivery during the past 12 months (January to December 2021).

Results

Twenty-three (of whom female: 14; 60.8%) managers or lead physicians of OAT units completed the questionnaire reporting that, in 2021, most OAT units (91.3%, n = 21) still practiced some adjusted approaches as established in the beginning of the pandemic. The most common adaptions were special protocols for COVID-19 cases (95.7%, n = 22), increased use of telephone- (91.3%, n = 21) and video consultations (87.0%, n = 20), and longer take-home intervals for OAT medications (52.2%, n = 12). The use of depot buprenorphine also increased substantially during the pandemic. According to the OAT providers, most patients handled flexible treatment provision well. In individual cases, patients’ substance use was identified as key factor necessitating a reintroduction of supervised dosing and drug screening. Collaboration with general practitioners and municipal health and social services was generally perceived as crucial for successful treatment delivery.

Conclusions

Overall, the Norwegian OAT system proved resilient in the second year of the COVID-19 pandemic, as its healthcare workforce embraced innovation in technology (telemedicine) and drug development (depot buprenorphine). According to our nationally representative sample of OAT providers, most patients were compliant with longer take-home doses of methadone and buprenorphine. Our findings suggest that telemedicine can be useful as adjunct to face-to-face treatment and provide greater flexibility for patients.