bluuebunny/crossref_metadata_2025 huggingface dataset:
Professional and Communicative Proficiency of a Mentor as a Tool of Image Building in Public Service
Authors: Kemenev D.A.
Published: August 2020

The article investigates the imageological aspect of mentor’s communicative competence in public service and reveals the communicative functions of mentor’s image in relation to the mentees. The author determines the communicative skills necessary for the mentor in all processes and stages of this personnel technology. Based on the analysis of scientific publications, the author discloses and justifies the role models of mentor’s behavior in relation to the mentees from the perspective of the mentor’s image, authority, and communicative competence. The author has conducted an expert survey among public servants, which allowed identify the main professional, business, moral, psychological, and integral qualities that are the most effectively developed by the public servant in the process of performing mentor’s functions. As a result, the author suggests a structural-logical model of the communicative competence of a mentor in the public service in the process of perceiving its communicative knowledge, skills, and competencies for achieving the effectiveness of mentoring.
Exhibition and Trade Fair Activity and Economic Crises: response measures and factors for recovery
Authors: Nazarov A.A.
Published: August 2020

The paper represents the analysis of the impact on the exhibition and trade fair activity of the Russian Federation during crisis situations caused by external factors. The author examined the major anticrisis measures, industry statistics and the main trends in the postcrisis phase. The fundamental role of the exhibition industry as a tool is caused by stimulation of economic sectors recovery from the crisis due to the multiplier effect. The particular relevance of the article is justified by a comprehensive study of the state of the industry during the current crisis caused by the COVID-19 pandemic. The author provides an overview of main government support measures for the industry and explains factors that have reduced some of these measures. Also, the author examined in detail activities of non-governmental organizations and associations of the exhibition industry in lobbying for the provision of state support and educational and legal assistance to Russian exhibition companies. Thus, the importance of coordinating activities of all participants in the exhibition industry and, in particular, further consolidation of interaction at the level of industry associations, becomes apparent. Besides, the author suggests a number of measures, such as highlighting exhibitions, trade fairs and congresses from the list of mass events following the example of Germany, introducing insurability for exhibition organizers in case of postponement or cancellation of events due to emergency circumstances, standardizing public health and hygiene rules. Their practical application should mitigate the way out of the current situation.
The Effects of Common Vetch Grain (Vicia Satıva) on Some Blood, Rumen Parameters and Rumen Protozoa in Lambs
Authors: BUDAĞ Cemal , TAŞ Evrim
Published: August 2020

This study investigated the effect of different levels of common vetch (CV) grain feed on some blood and rumen parameters and rumen protozoa in lambs consuming sainfoin hay (SH). In the study two-month-old weaned, SH consumed, 36.25 ± 2.49 kg average body weight (BW), twenty-four female lambs were used. Ration groups were established as follows; In the first group (C, control), 2% SH and 0.00% CV of the lamb's live weight (LW) were adopted while in the second group, 1.25% SH and 0.75% CV ( CVI) and in the third group, 0.5% SH and 1.50% CV (CVII) were adopted. Blood and rumen fluid samples were taken twice, once at the beginning of the study and once on the 30th day of the study. Although there were statistical differences in some of the parameters investigated in the study, all blood and rumen parameters were within the normal limits specified for lambs in the literature. In this study, it was concluded that feeding the lambs that are consuming SH with CV 1.5% of their live weight did not have a negative effect and the total ration can be formed using both SH and CV.
İstanbul Çırpıcı Kent Parkı’nın Engelli Kullanımı Açısından Değerlendirilmesi
Authors: TÜRCAN İMREN Özüm , KİPER Tuğba
Published: August 2020

Bu çalışmada; "Kentsel dış mekânların kurgulamasında, farklı özelliklere sahip bütün bireylerin eşit şekilde erişilebilirliği ve kullanılabilirliğine yönelik kararlar geliştirilmelidir" hipotezi çerçevesinde; "Çırpıcı Kent Parkı engelliler açısından kullanılabilir ve erişilebilir mi?" sorusuna yanıt aranmıştır. Bu amaçla; Çırpıcı Parkı'nda, kent parklarının kullanım olanaklarının engelliler açısından değerlendirilmesi hedeflenmiştir. Çalışma; arazi gözlemleri ve konu ile ilgili literatürlere dayalı olarak geliştirilerek, görsel materyallerle desteklenmiştir. Park alanı; ulaşılabilirlik (park girişi, yaya yolu, merdiven, rampa, otopark), peyzaj donatı elemanları (oturma elemanı, işaret ve yönlendirme levhası, aydınlatma elemanı, çöp kutusu), kullanım ve aktivite (çocuk oyun alanı, spor alanı) ile bitkilendirmeye ilişkin özellikler, engellilere yönelik dış mekân standartları bakımından analiz edilerek sorgulanmıştır. Bulgular kapsamında engellilere yönelik sorunlar değerlendirilerek mevcut durumun iyileştirilmesi için çözüm önerileri geliştirilmiştir. Sonuç olarak, sadece engelli bireyler için değil herkes için tasarımın ön planda tutulmasının önemi vurgulanmıştır.
Analysis of the Solutions of the Equation Modeled in the Field of Nonlinear Sciences
Authors: AKTÜRK Tolga , DİKİCİ Mahşure Kübranur
Published: August 2020

In this article, the travelling wave solutions of the fourth-order nonlinear Ablowitz-Kaup-Newell-Segur (AKNS) equation are investigated using the modified exponential function method (MEFM). This method is used to find analytical travelling wave solutions of the AKNS equation. The different travelling wave solutions are obtained by determining the appropriate values for the parameters. Two and three dimensional graphics of the different wave solutions found in this way are plotted with the help of Mathematica package program by determining the appropriate parameters.
Features of Physical Development Among 12 Years Old Children
Authors: Malinauskas Ramualdas Kazemirovich , Galdikas Simas
Published: August 2020

The purpose of the study is to compare the indicators of the physical development of 12 years aged children in the main and preparatory groups of physical fitness. The study of physical development in the main and preparatory groups (among 12 years old boys and girls) was carried out by clinical anthropometry with determination of body length and weight, as well as physiometry with determination of lung capacity and muscle strength of the right and left hands. It turned out that the strength of the left and right hands of boys assigned to the main group of medical fitness was statistically significantly higher than that of boys assigned to the preparatory group of physical fitness.
Features of the Psycho-Emotional State of Future Specialists in the Field of Physical Education and Sports
Authors: Malinauskas Ramualdas Kazemirovich , Kunstas Andrius Viliusovich
Published: August 2020

The purpose of the study is to analyse the characteristics of the psycho-emotional state of future specialists in the field of physical education and sports. To achieve this goal, two methods were used: A. Antonovsky scale for assessing the sense of coherence and a scale for assessing the level of stress tolerance (Thermometer according to Kiselev). The results showed that the future coaches have a better psycho-emotional state than future physical education teachers because they are more resistant to stress.
Virtual exchanges as complex research environments: facing the data management challenge. A case study of Teletandem Brasil
Authors: Aranha Solange , Wigham Ciara R.
Published: August 2020

Although there is a move toward open data, with research funding bodies more frequently requiring data management plans and dissemination strategies, the data management challenges inherently linked to virtual exchange research are understudied. Data collection is often reported upon in papers addressing interaction analysis or language development, but little attention has been paid to offering critical discussion of data collection and structuration methods or practical advice to encourage data/corpora dissemination. This paper reports on two phases of the Multimodal Teletandem Corpus project (Aranha & Lopes, 2019) that structured 581 hours of video data from Portuguese-English teletandem sessions, 351 chat logs, 956 written productions exchanged between the partners (original, revised, and corrected versions), 91 initial and 41 final questionnaires, and 666 learning diaries. We describe the data management problems faced that included the organization of data collected, ethical consent, management of a large quantity of data, inclusion of sociolinguistic information, expansion of learning theories, and the solutions found. We then outline data management planning steps that, consequently, are being introduced for future telecollaboration instantiations.
Increasing Awareness and Use of Mobile Health Technology Among Individuals With Hypertension in a Rural Community of Bangladesh: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Jahan Yasmin , Moriyama Michiko , Rahman Md Moshiur , Kazawa Kana , Rahman Atiqur , Sayeem Bin Shahid Abu Sadat Mohammad , Das Sumon Kumar , Golam Faruque Abu Syed , Jobayer Chisti Mohammod
Published: August 2020

BACKGROUND

Hypertension remains one of the foremost noncommunicable diseases that most often lead to cardiovascular diseases and its different complications. The prevalence of hypertension in Bangladesh has been increasing. However, there are very limited studies that have evaluated the impact of health education and awareness development in mitigating the burden of hypertension and its complications in Bangladesh.

OBJECTIVE

This study aims to increase awareness, enhance knowledge, and change lifestyle behaviors through health education and the use of mobile health (mHealth) technology among individuals with hypertension living in a rural community of Bangladesh.

METHODS

A randomized controlled trial is underway in a Mirzapur subdistrict of Bangladesh. This trial compares two groups of individuals with hypertension: The comparison arm receives health education and the intervention arm receives health education and a periodic mobile phone–based text message intervention. The trial duration is 5 months. The primary end point is participants’ actual behavior changes brought about by increased awareness and knowledge.

RESULTS

Enrollment of participants started in August 2018, and collection of follow-up data was completed at the end of July 2019. A total of 420 participants volunteered to participate, and among them, 209 and 211 were randomly allocated to the intervention group and the control group, respectively. Among them, the ratio of males/females was 12.0/88.0 in the intervention group and 16.1/83.9 in the control group. Data cleaning and analyses have been completed and the results have been submitted for publication.

CONCLUSIONS

Periodic short education using mHealth technology in addition to face-to-face health education may be an effective method for increasing awareness and knowledge about behavioral changes and maintaining healthy lifestyle behaviors.

CLINICALTRIAL

Bangladesh Medical Research Council (BMRC) 06025072017; ClinicalTrials.gov NCT03614104, https://clinicaltrials.gov/ct2/show/NCT03614104; University hospital Medical Information Network (UMIN) R000033736, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_his_list.cgi?recptno=R000033736

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/15523
Deep Learning–Assisted Burn Wound Diagnosis: Diagnostic Model Development Study (Preprint)
Authors: Chang Che Wei , Lai Feipei , Christian Mesakh , Chen Yu Chun , Hsu Ching , Chen Yo Shen , Chang Dun Hao , Roan Tyng Luen , Yu Yen Che
Published: August 2020

BACKGROUND

Accurate assessment of the percentage total body surface area (%TBSA) of burn wounds is crucial in the management of burn patients. The resuscitation fluid and nutritional needs of burn patients, their need for intensive unit care, and probability of mortality are all directly related to %TBSA. It is difficult to estimate a burn area of irregular shape by inspection. Many articles have reported discrepancies in estimating %TBSA by different doctors.

OBJECTIVE

We propose a method, based on deep learning, for burn wound detection, segmentation, and calculation of %TBSA on a pixel-to-pixel basis.

METHODS

A 2-step procedure was used to convert burn wound diagnosis into %TBSA. In the first step, images of burn wounds were collected from medical records and labeled by burn surgeons, and the data set was then input into 2 deep learning architectures, U-Net and Mask R-CNN, each configured with 2 different backbones, to segment the burn wounds. In the second step, we collected and labeled images of hands to create another data set, which was also input into U-Net and Mask R-CNN to segment the hands. The %TBSA of burn wounds was then calculated by comparing the pixels of mask areas on images of the burn wound and hand of the same patient according to the rule of hand, which states that one’s hand accounts for 0.8% of TBSA.

RESULTS

A total of 2591 images of burn wounds were collected and labeled to form the burn wound data set. The data set was randomly split into training, validation, and testing sets in a ratio of 8:1:1. Four hundred images of volar hands were collected and labeled to form the hand data set, which was also split into 3 sets using the same method. For the images of burn wounds, Mask R-CNN with ResNet101 had the best segmentation result with a Dice coefficient (DC) of 0.9496, while U-Net with ResNet101 had a DC of 0.8545. For the hand images, U-Net and Mask R-CNN had similar performance with DC values of 0.9920 and 0.9910, respectively. Lastly, we conducted a test diagnosis in a burn patient. Mask R-CNN with ResNet101 had on average less deviation (0.115% TBSA) from the ground truth than burn surgeons.

CONCLUSIONS

This is one of the first studies to diagnose all depths of burn wounds and convert the segmentation results into %TBSA using different deep learning models. We aimed to assist medical staff in estimating burn size more accurately, thereby helping to provide precise care to burn victims.
Effects of Feedback From Self-Monitoring Devices on Lifestyle Changes in Prediabetes Workers: A 3-Month Randomized Controlled Trial (Preprint)
Authors: Nagata Tomohisa , Aoyagi Sona-Sanae , Takahashi Minekazu , Nagata Masako , Mori Koji
Published: August 2020

BACKGROUND

Although lifestyle interventions are useful in prevention and management of diabetes, they can be expensive and time-consuming. There is some evidence for the effectiveness of automated mobile technology for health self-monitoring, however, no studies have used such devices with prediabetes workers.

OBJECTIVE

We aimed to examine the effectiveness of a 3-month digital self-monitoring device on glucose levels and health behaviors of prediabetes workers in Japan. The primary outcome was blood glucose levels and the secondary outcomes were changes in health behaviors and BMI.

METHODS

A two-arm randomized controlled trial was conducted with workers from 23 organizations. The intervention group (n=50, data analyzed for n=46) wore an armband activity monitor, a body composition monitor, and a blood pressure monitor for 3 months and received semi-automated weekly email messages tailored to their device data. The control group (n=53, data analyzed for n=48) engaged in no self-monitoring. Messages were developed by a physician and a dietician. Post-intervention changes in blood glucose levels, BMI, and health behaviors were compared between the intervention and control groups using blood tests and device data.

RESULTS

At the end of 3 months, the intervention group showed significantly lower blood glucose levels (HbA1c [%]: intervention mean 6.4 vs. control mean 6.6; Cohen d=0.7; 95% CI 0.2-1.1; P=.009) and significantly greater motivation to increase their daily exercise than the control group. There were no significant between-group differences in BMI or health behaviors.

CONCLUSIONS

Mobile digital self-monitoring was effective in improving blood glucose levels and motivation to increase daily exercise in prediabetes workers. The use of digital health devices is a cost-effective way of implementing health self-monitoring for large numbers of individuals in the workplace.

CLINICALTRIAL

This study is registered with the University Hospital Medical Information Network (UMIN000023651).
Predicting Risk of Stroke From Lab Tests Using Machine Learning Algorithms: Development and Evaluation of Prediction Models (Preprint)
Authors: Alanazi Eman M , Abdou Aalaa , Luo Jake
Published: August 2020

BACKGROUND

Stroke, a cerebrovascular disease, is one of the major causes of death. It causes significant health and financial burdens for both patients and health care systems. One of the important risk factors for stroke is health-related behavior, which is becoming an increasingly important focus of prevention. Many machine learning models have been built to predict the risk of stroke or to automatically diagnose stroke, using predictors such as lifestyle factors or radiological imaging. However, there have been no models built using data from lab tests.

OBJECTIVE

The aim of this study was to apply computational methods using machine learning techniques to predict stroke from lab test data.

METHODS

We used the National Health and Nutrition Examination Survey data sets with three different data selection methods (ie, without data resampling, with data imputation, and with data resampling) to develop predictive models. We used four machine learning classifiers and six performance measures to evaluate the performance of the models.

RESULTS

We found that accurate and sensitive machine learning models can be created to predict stroke from lab test data. Our results show that the data resampling approach performed the best compared to the other two data selection techniques. Prediction with the random forest algorithm, which was the best algorithm tested, achieved an accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of 0.96, 0.97, 0.96, 0.75, 0.99, and 0.97, respectively, when all of the attributes were used.

CONCLUSIONS

The predictive model, built using data from lab tests, was easy to use and had high accuracy. In future studies, we aim to use data that reflect different types of stroke and to explore the data to build a prediction model for each type.
Correction: The Relationship Between Health Management and Information Behavior Over Time: A Study of the Illness Journeys of People Living With Fibromyalgia (Preprint)
Authors: Chen Annie T
Published: August 2020

UNSTRUCTURED

REMOVE
La disputa simbólica por clasificar un nuevo producto cultural: el caso de Netflix durante el estreno y la premiación de la película Roma
Authors: Battezzati Santiago
Published: August 2020

Las investigaciones sobre industrias culturales han señalado la importancia de observar cómo los generadores de contenido se disputan la escasa atención que las personas dedican a los pro-ductos culturales. A partir del análisis de las controversias en torno al estreno en México y la premiación en los Óscar de la película Roma, coproducida por Netflix, este artículo expondrá algunos de los debates sobre la definición simbólica de un nuevo producto cultural. Sostene-mos que dicho proceso de definición es una parte central de la disputa económica por la aten-ción del espectador. Prestar atención a tales debates y disputas es fundamental en un contexto histórico en el que las nuevas posibilidades tecnológicas parecen favorecer la emergencia de nuevos actores y productos en las industrias culturales.
Cambios y continuidades en la política migratoria durante el primer año del gobierno de López Obrador
Authors: Calva Sánchez Luis Enrique , Torre Cantalapiedra Eduardo
Published: August 2020

La administración de Andrés Manuel López Obrador ha tenido que gestionar la migración en tránsito por el territorio mexicano —incluidas las caravanas de migrantes— haciendo frente a las exigencias del gobierno de Donald Trump de que México impida que los migrantes alcan-cen el territorio estadounidense. El objetivo de este trabajo es analizar los cambios y continui-dades en la política migratoria durante el primer año de López Obrador, a través de la revisión documental y el análisis de los datos de registros administrativos. Asimismo, son examinados dos aspectos clave de esta política: la contención de la migración y la protección de los migrantes.
Trade opportunities within MIKTA: A Macroeconomic comparative analysis between Mexico, Indonesia and Turkey (2000-2019)
Authors: Reyes Guzmán Gerardo , Escobar Acevedo Marco Antonio , Rostro Hernández Perla Esperanza , León Pérez Damaris
Published: August 2020

This paper aims at exploring trade opportunities between Mexico, Indonesia, and Turkey, presently members of MIKTA, by comparing their respective Macroeconomic and socio-economic variables. We use the GDP per capita as a key indicator of productivity and market size to see which MIKTA members are similar and therefore have a potential to set trade and business projects among them. To do that we conducted an ANOVA test and skiped Australia and South Korea of the analysis due to their high income per capita. We then focused on Mexico, Indonesia, and Turkey, whose economies proved to be equivalent and compared their key macroeconomic and social indicators, outstanding their most competitive sectors, commodities, foreign trade, and trade partners. A total of 87 observations were rated from one to three to identify which country was better. Mexico scored 205 points followed by Indonesia with 164 and Turkey, 153 points. Finally, we ran a second ANOVA test, taking the value of all observations in a logarithmic scale to prove that in spite of the different scores, the mean of the three countries was equal. The results are relevant as the three of them present a wide business scope to be exploited, which could allow them to lead the MIKTA in the coming decades.
Akibat Hukum Pencairan Kredit Yang Didasarkan Pada Covernote Notaris
Authors: Yusmi Silvia Anggraini
Published: August 2020

Tujuan penelitian ini ialah untuk mengkaji dan menganalisis akibat hukum pencairan kredit yang didasarkan pada covernote notaris. Tipe penelitian yang digunakan dalam penelitian ini ialah penelitian yuridis normatif dengan menggunakan pendekatan undang-undang, pendekatan konseptual, dan pendekatan kasus. Hasil dari penelitian Covernote yang dibuat atas dasar kesepakatan Notaris dan Bank dalam pencairan kredit adalah sah, namun hanya berkedudukan  sebagai  surat keterangan  dari notaris dan tidak memiliki kekuatan hukum karena tidak ada kewenangan Notaris dalam pembuatan suatu Covernote. Akibat hukum pencairan kredit yang didasarkan pada covernote Notaris adalah apabila tidak dapat diselesaikan pengurusan hak tanggungan sesuai dengan covernote yang dibuat oleh Notaris, maka berakibat objek jaminan dalam perjanjian hak tanggungan tidak dapat dieksekusi langsung atau perjanjian hak tanggungan batal demi hukum sedangkan perjanjian kreditnya belum berakhir. Covernote Notaris tidak memiliki kekuatan hukum untuk memberikan perlindungan hukum bagi bank selaku kreditur dalam perjanjian kredit apabila terjadi wanprestasi pada saat proses pembebanan hak jaminan. Notaris dapat dimintakan pertanggungjawaban atas kesalahannya jika dalam penerbitan covernote tersebut terdapat unsur yang memuat keterangan yang tidak benar terhadap isi covernote tersebut.

Kata Kunci: Covernote, Notaris, Perbankan
Status Badan Hukum Usaha Ekonomi Desa/Kelurahan Simpan Pinjam (UED/K-SP) di Kecamatan Bengkalis
Authors: Yalid Yalid
Published: August 2020

ABSTRAK

 

Rumusan masalah dalam penelitian ini ada 3 (tiga). Pertama, Bagaimanakah pendirian badan hukum UED/K-SP di Kecamatan Bengkalis? Kedua, bagaimanakah hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis? Ketiga, bagaimanakah upaya mengatasi hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis? Sejalan dengan rumusan masalah tersebut maka tujuan penelitian ini pun ada 3 (tiga). Pertama,  untuk menjelaskan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis. Kedua,untuk menjelaskan hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis. Ketiga, untuk menjelaskan upaya mengatasi hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis. Jenis penelitianadalah penelitian hukum empiris untukmeninjau efektivitas berlakunya hukum. Lokasi penelitian di Kecamatan Bengkalis Kampar Kiri Hulu.  Pertimbangan penulis memilih lokasi ini karena dari legalitas pembentukan UED/K-SP yang merupakan unit usaha BUMDesa di Kecamatan Bengkalis ditinjau dari perspektif hukum bertolak belakang dengan Undang-Undang Nomor 1 Tahun 2013 tentang Lembaga Keuangan Mikro (LKM).Hasil penelitian ini  dapat dijelaskan  pendirian badan hukum UED/K-SP di Kecamatan Bengkalis haruslah berbentuk badan hukum sesuai amanat Pasal 4 huruf a Undang-Undang Nomor 1 Tahun 2013 jo Pasal 8 Permendes PDTT Nomor 4 Tahun 2015. Hasil penelitian ini dapat diketahui tidak ada satupun UED-SP di Kecamatan Bengkalis yang sudah memenuhi persyaratan LKM dan berbadan hukum. Hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis  dari hasil penelitian ini jawaban yang relevan hanyalah terkait peralihan aset, sedangkan jawaban selebihnya dari sampel penelitian tidak ada relevansinya dengan hambatan pendirian badan hukum UED/K-SP. Upaya mengatasi hambatan pendirian badan hukum UED/K-SP di Kecamatan Bengkalis tidak ada rencana dan tindakan konkrit untuk mengatasi hambatan dimaksud. Hal ini disebabkan karena seluruh sampel penelitian ini seluruhnya tidak memahami pendirian badan hukum UED/K-SP.

 

Kata Kunci: Status Badan Hukum, UED/K-SP, Kecamatan Bengkalis
Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy
Authors: Brierley Gemma V. , Webber Hannah , Rasijeff Eerika , Grocott Sarah , Siddle Kenneth , Semple Robert K.
Published: August 2020

Loss-of-function mutations in both alleles of the human insulin receptor gene (INSR) cause extreme insulin resistance (IR) and usually death in childhood, with few effective therapeutic options. Bivalent antireceptor antibodies can elicit insulin-like signaling by mutant INSR in cultured cells, but whether this translates into meaningful metabolic benefits in vivo, wherein the dynamics of insulin signaling and receptor recycling are more complex, is unknown. To address this, we adopted a strategy to model human insulin receptoropathy in mice, using Cre recombinase delivered by adeno-associated virus to knockout endogenous hepatic Insr acutely in floxed Insr mice (liver insulin receptor knockout [L-IRKO] + GFP), before adenovirus-mediated add back of wild-type (WT) or mutant human INSR. Two murine anti-INSR monoclonal antibodies, previously shown to be surrogate agonists for mutant INSR, were then tested by intraperitoneal injections. As expected, L-IRKO + GFP mice showed glucose intolerance and severe hyperinsulinemia. This was fully corrected by add back of WT but not with either D734A or S350L mutant INSR. Antibody injection improved glucose tolerance in D734A INSR-expressing mice and reduced hyperinsulinemia in both S350L and D734A INSR-expressing animals. It did not cause hypoglycemia in WT INSR-expressing mice. Antibody treatment also downregulated both WT and mutant INSR protein, attenuating its beneficial metabolic effects. Anti-INSR antibodies thus improve IR in an acute model of insulin receptoropathy, but these findings imply a narrow therapeutic window determined by competing effects of antibodies to stimulate receptors and induce their downregulation.
Opposing Associations of NT-proBNP With Risks of Diabetes and Diabetes-Related Complications
Authors: Birukov Anna , Eichelmann Fabian , Kuxhaus Olga , Polemiti Elli , Fritsche Andreas , Wirth Janine , Boeing Heiner , Weikert Cornelia , Schulze Matthias B.
Published: August 2020

OBJECTIVE

Circulating N-terminal pro B-type natriuretic peptide (NT-proBNP) is a classic diagnostic and prognostic marker for heart failure. However, it is inversely associated with diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of diabetes-related complications in initially healthy individuals.

RESEARCH DESIGN AND METHODS

We performed a case-cohort study within the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam cohort including a random subcohort (n = 1,294) and incident cases of type 2 diabetes (n = 649) and cardiovascular diseases (n = 478). Incident cases of type 2 diabetes (n = 545) were followed up for microvascular (n = 133) and macrovascular (n = 50) complications. Plasma NT-proBNP was measured at baseline in initially healthy participants.

RESULTS

In multivariable models, NT-proBNP was linearly inversely associated with incident type 2 diabetes with a hazard ratio (HR) (95% CI) per doubling in NT-proBNP of 0.91 (0.86, 0.98). The association was only observable in women (0.80 [0.72, 0.90]) compared with men (0.98 [0.91, 1.07]). Among people with incident diabetes, NT-proBNP was positively associated with diabetes complications: overall, 1.31 (1.13, 1.53); microvascular complications, 1.20 (1.01, 1.43); and macrovascular complications, 1.37 (1.03, 1.83).

CONCLUSIONS

Although higher NT-proBNP levels are associated with lower diabetes risk, NT-proBNP is a biomarker for vascular complications in people who develop diabetes independent of potential confounders. Thus, NT-proBNP might be informative to monitor risk for diabetes-related microvascular and macrovascular complications, which should be further explored in future prospective studies.
Opposing associations of NT-proBNP with risks of diabetes and diabetes-related complications
Authors: Birukov Anna , Eichelmann Fabian , Kuxhaus Olga , Polemiti Elli , Fritsche Andreas , Wirth Janine , Boeing Heiner , Weikert Cornelia , Schulze Matthias B.
Published: August 2020

Objective: Circulating
N-terminal pro b-type natriuretic peptide (NT-proBNP) is a classic diagnostic
and prognostic marker for heart failure. However, it is inversely associated with
diabetes risk. We aimed to investigate relationships of NT-proBNP with risk of
diabetes-related complications in initially healthy individuals.

Research Design and Methods: We performed a case-cohort study within the
European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam
cohort including a random subcohort (n=1294) and incident cases of type 2
diabetes (n=649) and cardiovascular diseases (CVD, n=478). Incident cases of
type 2 diabetes (n=545) were followed up for micro- (n=133) and macrovascular
(n=50) complications. Plasma NT-proBNP was measured at baseline in initially
healthy participants.

Results: In multivariable models, NT-proBNP was linearly inversely associated
with incident type 2 diabetes, HR (95% CI) per doubling in NT-proBNP: 0.91
(0.86; 0.98). The association was only observable in women, HR (95%CI): 0.80
(0.72; 0.90), compared to 0.98 (0.91; 1.07) in men. Among persons with incident
diabetes, NT-proBNP was positively associated with diabetes complications, HR (95%
CI): 1.31 (1.13; 1.53) for overall, 1.20 (1.01; 1.43) for micro- and 1.37 (1.03;
1.83) for macrovascular complications.

Conclusions: Although higher NT-proBNP levels are associated with lower diabetes
risk, in persons who develop diabetes NT-proBNP is a biomarker for vascular
complications independent of potential confounders. Thus, NT-proBNP might be informative
to monitor risk for diabetes-related micro- and macrovascular complications,
which should be further explored in future prospective studies.
Rapid powder analysis with laser-induced breakdown spectroscopy at low pressure ambient helium gas employing bamboo charcoal as a sample holder
Authors: Tanra Ivan , Karnadi Indra , Pardede Marincan , Hedwig Rinda , Marpaung Mangasi Alion , Kurniawan Koo Hendrik , Kagawa Kiichiro
Published: August 2020

Several experiments are performed to explore the possible benefits of using bamboo charcoal as a sample holder for rapid powder analysis using laser-induced breakdown spectroscopy at low-pressure helium ambient gas. Standard powdered samples such as ZnS and CuSO4 are used to demonstrate the feasibility of using cheap and widely available bamboo charcoal as a sample holder. A commercial baby milk powder and several sets of soil samples with a tiny amount of impurities are also introduced to show the potential application of bamboo charcoal as a powder holder. By appropriately adjusting the laser pulse energy and the thickness of the powder layer, we successfully obtained a spectrum that is free from the undesirable matrix effect. A remarkable result was obtained, even using a tiny amount of the powder sample. This proposed method is considered notably promising for the rapid analysis of the powder sample, especially with a very limited amount.
A Review of Literature in Applied Five Factor Model of Personality among Staff at Workplace
Authors: Mehrad Aida
Published: August 2020

Staff feeling and performance at the workplace and obtaining a high level of outcomes drive from various factors; in truth, the human being is complicated and there are numerous internal and external factors that have an impact on it. Personality determined as one of these main internal factors that introduced individuals at their personal and social life; furthermore, recognizing its deep definition and effect on the approach and accomplishment of staff stays valuable and essential. Personality consists of five main factors: neuroticism, extraversion, openness, agreeableness, and conscientiousness that each person based on these factors illustrates dissimilar behavior and response. Additionally, the person introduced or well-known via these factors. Incidentally, the present literature review surveys five personality factors amongst staff in the context of the five-factor model and analyzes staff performance and behavior at the workplace. Overall, the study emphasized the role of managers, leaders, supervisors, etc. at the workplace to identify and evaluate staff personality, because by recognizing staff personality managers can offer a suitable solution to coping and solving any type of conflict or issue.
Deterministic Finite State Model of Heart Cycle: Modeling and Simulation
Authors: Mulunda Christine K. , Svitenkov Andrew I.
Published: August 2020

Heart cycle model explores the deterministic finite state of heart cycle whereby the transition of blood is dependent of the state of the source and the input. Blood flowing in human body is a series of complex networks working together in a logic circuit. This research describes the complex mechanisms of heart cycle in relation to the inter-relationship between the chambers and valves, in a logical and one dimensional structure. Logical operators and tristate buffer are used to map the states of the chamber and valves as it relaxes/contracts and open/close respectively, in truth tables. Mathematical analysis is used to model the state and outflow behavior of heart cycle in discrete time.
The Influence of Market Orientation and Product Innovation on the Competitive Advantage and Its Implication toward Small and Medium Enterprises (Ukm) Performance
Authors: Herman Hendri , Hady Hamdy , Arafah Willy
Published: August 2020

This study aims to: (1) determine the effect of market orientation on competitive advantage; (2) to know the effect of innovation on competitive advantage; (3) to know the influence of market orientation and product innovation together to competitive advantage; (4) the effect of market orientation on the performance of SMEs, (5) to know the effect of product innovation on the performance of SMEs, (6) to know the effect of competitive advantage on SMEs performance, and (7) to know the effect of market orientation, product innovation, and competitive advantage together SMEs.

This research uses an explorative design that aims to conduct a search and reveal the factors that can be estimated as the cause of the occurrence of a condition that is not yet known the cause and the mechanism.The population in this study is the SMEs in Batam city with the type of production business with a population of 153 SMEs. The number of samples was determined using a saturated sample technique in which the entire population in the study was sampled. So the number of samples in this study was as many as 153 SMEs.

From the results of the study found that market orientation has a positive and significant impact on competitive advantage. Product innovation has a positive and significant impact on competitive advantage. Market orientation and product innovation together have a positive and significant impact on competitive advantage with R2 value of 83%. The dominant variable influencing competitive advantage is product innovation with regression coefficient value 0,62. Market orientation has a positive and significant effect on SME's performance. Product innovation has a positive and significant effect on SME's performance. Competitive advantage positively and significantly influence to SMEs performance, market orientation, product innovation and competitive advantage together have positive and significant influence to SMEs performance with R2 value equal to 90%. The dominant variable affecting the performance of SMEs is the advantage of competing with the value of regression coefficient 0.47.

This research offers implementation to SMEs to improve market orientation and product innovation so that it will increase competitive advantage which impact on SMEs performance.
Evaluation of right ventricle systolic and diastolic function in patients with paroxysmal atrial fibrillation
Authors: Cuglan Bilal , Ermis Necip , Yetkin Ertan , Karakas Yasin , Kurtoglu Ertugrul , Ozdemir Ramazan
Published: August 2020

Objective: Atrial fibrillation (AF) is frequently an electrical sign of underlying structural heart disease. Structural remodeling may begin not only in ventricles but also in atrium secondary to AF. In this study, we sought to investigate the effect of paroxysmal atrial fibrillation (PAF) on right ventricle function. Method: We prospectively analyzed 30 patients diagnosed with PAF and 25 control individuals. Cardiac risk factors and medical treatment of patients were obtained and recorded in both groups. Right ventricle tricuspid annular plane systolic excursion (TAPSE) and Tei indexes were measured as an indicator of right ventricular function. Results: There was no statistical difference between groups in terms of demographic and clinical characteristics. Tei index was higher and TAPSE was lower in PAF group compared to control individuals (p > 0.05). There was no statistically significant difference between PAF and control groups in terms of right ventricular diastolic functions neither. Although isovolumic relaxation time (IVRT) was higher in PAF group, it did not give statistical significance. Conclusion: In this study, even not being statistically significant Tei index, which assess right ventricular function was over upper limit in PAF patients. This may have been as the result of prolonged IVRT. This result may indicate that right ventricular diastolic functions may be effected in patients with PAF
Factors affecting the arrival time to hospital of patients with acute ischemic stroke
Authors: Haki Cemile , Cetiner Mustafa , Kaya Halil
Published: August 2020

Objective: It is known that intravenous thrombolytic therapy in ischemic stroke is beneficial in selected patients who arrived within the first 4.5 hours after the onset of the symptoms and the effectiveness of the treatment depends on early arrival to the hospital. The more patients arrival to the hospital within this time zone, the more they will have the chance to receive thrombolytic therapy. This study aims to investigate the factors that cause delay in the arrival of patients with ischemic stroke to the hospital. Methods: Patients diagnosed with acute ischemic stroke who applied to the neurology outpatient clinic and emergency room between February and May 2019 were included in the study. A direct interview survey was conducted to investigate the factors that delay the arrival to patients or relatives of the patients arrival to Bursa Yuksek Ihtisas Training and Research Hospital due to acute stroke. According to the time of arrival to the hospital after the onset of stroke symptoms, patients were classified as early ( 4.5 hours) and late arrival (> 4.5 hours). Based on this grouping, factors causing delay in patients' access to hospital were compared statistically. Results: A total of 251 patients and / or patient relatives who arrived to the emergency and neurology outpatient clinic were interviewed. Of the 251 patients included in the study, 119 (47.4%) were female and the mean age was 70 (34-94) years. Approximately 72.5% of the patients were arrived in the first 4.5-hour slice after the onset of stroke symptoms. Factors causing late arrival were determined as being female, having low NIHSS score and not using ambulance in transportation. Conclusion: Due to the delay in arrival of 27.5% of the patients, there is no chance to apply thrombolytic therapy to eligible ones. The factors resulting in the delay were discovered as female gender, low severity of the stroke and transportation without ambulance. In this respect, community-oriented trainings are required.
Atrial fibrillation and gamma glutamyl transferase; Off-pump versus on-pump Coronary Artery Bypass surgery
Authors: Emced Khalil
Published: August 2020

Introduction: Atrial fibrillation (AF) which can be seen as a complication of the open-heart surgery, may cause serious problems on postoperative period. The exact pathophysiology of AF is unknown but it is thought that factors such as oxidative stress might cause AF. Material and methods: We retrospectively surveyed the serum gamma-glutamyl transferase (GGT) levels which is accepted as a mediator of oxidative stres, for the Post Operative Atrial Fibrillation (POAF) that occur after of-pump versus on-pump Coronary Artery Bypass Graft (CABG) surgery. Our study included 183 cases (101 male, 72 female; median age 63 ± 4.3 years) of which CABG was performed. Results: Echocardiography, routine blood tests, electrocardiography (ECG), test for the serum GGT levels were performed in preoperative and postoperative period to all participants. AF developed in 34 patients (35 %) in Group I and 19 patients (20 %) in Group II. There were no significant differences between two groups (of-pump versus on-pump) in terms of gender, cardiovascular risk factors and the severity of the coronary artery disease. In patients who has developed AF in postoperative period had significantly higher serum GGT levels. Conclusion: This study has shown that serum GGT levels were found to be significantly higher in patients whom AF has developed after on-pump CABG surgery.
The association of recurrent abdominal pain and Helicobacter pylori infection in correlation with esophagogastroduodenoscopy findings
Authors: Osmančević Lejla , Osmančević Emir
Published: August 2020

Abstract: Aim: The aim of this research was to determine the association of recurrent abdominal pain and Helicobacter pylori (H. pylori) infection in childhood, in correlation with the finding of an upper endoscopy. Introduction: Recurrent abdominal pain (RAP) was defined according to Apley and Naish's criteria from the year 1959 as at least three or more episodes of abdominal pain lasting longer than three months in children older than 3 years, and severe enough to prevent normal activities in child. The association of RAP and H. pylori has been analyzed in several different researches, and there are conflicting results about their interconnection. However, the etiological association of the presence of H. pylori with the onset and development of acute and chronic active gastritis and duodenal ulcer is known. Material and method: The research protocol included a total of 77/183 (42.07%) children divided by age into three subgroups: preschool age (3 to 6.9 years), school-age (7 to 10.9 years) and adolescent age (11 to 15 years) in whom the diagnosis of RAB was determined by meeting the criteria according to Apley and Naish (1959), and the American Academy of Pediatrics (2005). H. pylori infection was confirmed by enzyme-linked immunosorbent assay (ELISA), while esophagogastroduodenoscopy was performed by the device for upper endoscopy type Olimpus GIF Type Q156, in the endoscopic cabinet of the Clinic for Internal Medicine, University Clinical Center Tuzla. Results: Of the total number of examined children (77), the analyse of Helicobacter pylori infection presence showed the biggest number of positive findings in school age 91.3%, in adolescent age 78.0%, while the smallest number was in preschool age (25.0%). The most common findings of upper endoscopy and microscopic findings were described as: antritis acuta in 16%, gastritis chronica activa et erosiva in 32%, and duodenitis acuta (12%). Conclusion: A significant association of H. pylori infection and RAP are confirmed by positive finding of esophagogastroduodenoscopy, leading to conclusion that immunological testing for the presence of this bacteria is justified. After obtaining a positive finding with confirmed infecion, it is necessary to start with the treatment.
Suicidality in health crisis: Case reports
Authors: Cvjetković-Bošnjak Mina
Published: August 2020

Introduction: Suicide represents a major health problem of great importance for public health in Serbia. In the whole world in last decades, the number of committed suicides is constantly increasing. The most dramatic increase is the number of committed suicides among adolescents, but also among the elderly, over 65 years of age. Serbia ranks 13th in Europe in terms of the number of suicide(13.6/100.000 inhabitants) and Vojvodina is at the top place as region in Serbia (15.3/100.000 inhabitants). It is alarming that suicide attempts are 10-15 times more frequent, as well as that a large number of people who have committed suicide in the last month have reported in medical institutions with various problems. Situations and conditions that increase suicide risk are mental disorders and chronic physical illness, as well as life crises, which include pandemic. Also of great importance is positive heredity, as well as previous suicide attempts. Usually, during crisis, number of suicide attempts and committed suicides decline, but after crisis there is lot of evidence that symptoms of anxious and depressive disorders increase and number of suicide attempts and committed suicides is growing up. Case reports: In presented case reports the rigger for a suicide attempt was the current situation during the covid-19 epidemic. One of the leading reasons for the increase in number of attempted and committed suicides is the unrecognition and lack of treatment of mental disorder symptoms. Most frequently symptoms of depression and severe anxiety result in a suicide attempt. Early recognition and treatment either with psycho and/or pharmacotherapy in a significant percentage can reduce the number of attempted and committed suicides. Conclusion: In current pandemic and in next period, it is necessary for medical staff to look after various, but mostly depressive and anxious symptoms in patients, that frequently result in suicide attempt, if stay unrecognized and untreated. That is the best way to prevent suicide and to improve mental health, as it is very important for national interests.