bluuebunny/crossref_metadata_2025 huggingface dataset:
Occurrence of Chlamydiaceae and Chlamydia felis pmp9 Typing in Conjunctival and Rectal Samples of Swiss Stray and Pet Cats
Authors: Bressan Michelle , Rampazzo Antonella , Kuratli Jasmin , Marti Hanna , Pesch Theresa , Borel Nicole
Published: July 2021

Chlamydia (C.) felis primarily replicates in feline conjunctival epithelial cells and is an important cause of conjunctivitis in cats. Data on C. felis infection rates in stray cats in Switzerland has been missing so far. We performed a qPCR-based Chlamydiaceae-screening on 565 conjunctival and 387 rectal samples from 309 stray and 86 pet cats followed by Chlamydia species identification and C. felis typing using the gene pmp9, which encodes a polymorphic membrane protein. Overall, 19.1% of the stray and 11.6% of the pet cats were Chlamydiaceae-positive with significantly higher rates in cats displaying signs of conjunctivitis (37.1%) compared to healthy animals (6.9%). Rectal shedding of Chlamydiaceae occurred in 25.0% of infected cats and was mostly associated with concurrent ocular positivity (87.5%). In 92.2% of positive conjunctival and rectal samples, the Chlamydia species was identified as C. felis and in 2.6% as C. abortus. The C. felis pmp9 gene was very conserved in the sampled population with only one single-nucleotide polymorphism (SNP) in one conjunctival sample. In conclusion, C. felis strains are circulating in Swiss cats, are associated with conjunctivitis, have a low pmp9 genetic variability, and are rectally shed in about 16% of positive cases.
Biobased Ionic Liquids as Multitalented Materials in Lipidic Drug Implants
Authors: Júlio Ana , Sultane Anaisa , Viana Ana Silveira , Mota Joana Portugal , Santos de Almeida Tânia
Published: July 2021

Lipidic implants are valuable controlled delivery systems that present good biocompatibility and are useful for long-lasting therapies. However, these promising systems can present inflexible drug release profiles that limit their performance. Thus, finding new materials to overcome this drawback is crucial. Herein, lipidic implants containing caffeine and poorly soluble salicylic acid and rutin were developed. The inclusion of Gelucire® 50/02, sucrose, and two biobased ionic liquids, [Cho][Phe] and [Cho][Glu], were evaluated as a mean to improve the performance of the systems. The formulation procedure, dye content distribution, drug content, drug release, water content, and lipidic erosion of the developed systems were assessed. AFM analysis of the implants containing ILs was also performed. The results demonstrated that neither Gelucire® 50/02 nor sucrose were suitable tools to improve the drug release profile. In contrast, the ILs proved to be promising materials for multiple reasons; not only did they facilitate the formulation and incorporation of the studied drugs into the implants, but they also allowed a more suitable release profile, with [Cho][Glu] allowing a higher drug release due to its ability to increase surface wrinkling. Hence, this study showcases ILs as multitalented materials in lipid-based drug implants.
The Potential to Reduce Patient Co-Payment and the Public Payer Spending in Poland through an Optimised Implementation of the Generic Substitution: The Win-Win Scenario Suggested by the Real-World Big Data Analysis
Authors: Kardas Przemysław , Lichwierowicz Aneta , Urbański Filip , Szadkowska-Opasiak Beata , Karasiewicz Ewa , Lewek Paweł , Krupa Dominika , Czech Marcin
Published: July 2021

High medication costs are one of the major barriers to patient adherence. Medication affordability might be improved by generic substitution. The aim of this study was to assess the effectiveness of the implementation of generic substitution mechanisms in Poland. This was a retrospective analysis of nationwide real-world big data corresponding to dispensation of metformin preparations in 2019 in Poland. Relevant prescription and dispensation data were compared to assess the prevalence of generic substitution and its economic consequences. Among the 1,135,863 e-prescriptions analysed, a generic substitution was found in only 4.81% of the packs dispensed, based on e-prescriptions issued for metformin under its originator version and 2.73% under generic drugs. It is estimated that if these values were applied to the total Polish drug market, patients could lose the opportunity to lower their co-payment by 15.91% and the national payer to reduce its reimbursement expenditures by 8.31%. Our results point at the suboptimal implementation of generic substitution in Poland. Therefore, relevant actions need to be taken in order to maximise the benefits provided by this mechanism. It could not only lead to the win-win scenario in which both patients and the national payer are secured substantial savings, but it could also have a positive impact on patient adherence.
Green Synthesis of Heterogeneous Visible-Light-Active Photocatalysts: Recent Advances
Authors: Zuliani Alessio , Cova Camilla Maria
Published: July 2021

The exploitation of visible-light active photocatalytic materials can potentially change the supply of energy and deeply transform our world, giving access to a carbon neutral society. Currently, most photocatalysts are produced through low-ecofriendly, energy dispersive, and fossil-based synthesis. Over the last few years, research has focused on the development of innovative heterogeneous photocatalysts by the design of sustainable and green synthetic approaches. These strategies range from the use of plant extracts, to the valorization and recycling of metals inside industrial sludges or from the use of solventless techniques to the elaboration of mild-reaction condition synthetic tools. This mini-review highlights progresses in the development of visible-light-active heterogeneous photocatalysts based on two different approaches: the design of sustainable synthetic methodologies and the use of biomass and waste as sources of chemicals embedded in the final photoactive materials.
Mechanistic Association of Quantitative Trait Locus with Malate Secretion in Lentil (Lens culinaris Medikus) Seedlings under Aluminium Stress
Authors: Singh Chandan Kumar , Singh Dharmendra , Sharma Shristi , Chandra Shivani , Tomar Ram Sewak Singh , Kumar Arun , Upadhyaya K. C. , Pal Madan
Published: July 2021

Aluminium (Al) toxicity acts as a major delimiting factor in the productivity of many crops including lentil. To alleviate its effect, plants have evolved with Al exclusion and inclusion mechanisms. The former involves the exudation of organic acid to restrict the entry of Al3+ to the root cells while latter involves detoxification of entered Al3+ by organic acids. Al-induced secretion of organic acids from roots is a well-documented mechanism that chelates and neutralizes Al3+ toxicity. In this study, F6 recombinant inbred lines (RILs) derived from a cross between L-7903 (Al-resistant) and BM-4 (Al-sensitive) were phenotyped to assess variation in secretion levels of malate and was combined with genotypic data obtained from 10 Al-resistance linked simple sequence repeat (SSRs) markers. A major quantitative trait loci (QTL) was mapped for malate (qAlt_ma) secretion with a logarithm of odd (LOD) value of 7.7 and phenotypic variation of 60.2%.Validated SSRs associated with this major QTL will be useful in marker assisted selection programmes for improving Al resistance in lentil.
Raman Spectroscopy and Machine-Learning for Early Detection of Bacterial Canker of Tomato: The Asymptomatic Disease Condition
Authors: Vallejo-Pérez Moisés Roberto , Sosa-Herrera Jesús Antonio , Navarro-Contreras Hugo Ricardo , Álvarez-Preciado Luz Gabriela , Rodríguez-Vázquez Ángel Gabriel , Lara-Ávila José Pablo
Published: July 2021

Bacterial canker of tomato is caused by Clavibacter michiganensis subsp. michiganensis (Cmm). The disease is highly destructive, because it produces latent asymptomatic infections that favor contagion rates. The present research aims consisted on the implementation of Raman spectroscopy (RS) and machine-learning spectral analysis as a method for the early disease detection. Raman spectra were obtained from infected asymptomatic tomato plants (BCTo) and healthy controls (HTo) with 785 nm excitation laser micro-Raman spectrometer. Spectral data were normalized and processed by principal component analysis (PCA), then the classifiers algorithms multilayer perceptron (PCA + MLP) and linear discriminant analysis (PCA + LDA) were implemented. Bacterial isolation and identification (16S rRNA gene sequencing) were realized of each plant studied. The Raman spectra obtained from tomato leaf samples of HTo and BCTo exhibited peaks associated to cellular components, and the most prominent vibrational bands were assigned to carbohydrates, carotenoids, chlorophyll, and phenolic compounds. Biochemical changes were also detectable in the Raman spectral patterns. Raman bands associated with triterpenoids and flavonoids compounds can be considered as indicators of Cmm infection during the asymptomatic stage. RS is an efficient, fast and reliable technology to differentiate the tomato health condition (BCTo or HTo). The analytical method showed high performance values of sensitivity, specificity and accuracy, among others.
Foliar Zinc-Selenium and Nitrogen Fertilization Affects Content of Zn, Fe, Se, P, and Cd in Wheat Grain
Authors: Lončarić Zdenko , Ivezić Vladimir , Kerovec Darko , Rebekić Andrijana
Published: July 2021

The grain yield and concentrations of Fe, Zn, Se, Cd, and P in two winter wheat genotypes and in vitro bioaccessibility of Fe and Zn under the effect of different nitrogen fertilization and Zn-Se foliar application were evaluated. The total grain Fe, Zn, and Se concentrations, as well as Fe and Zn concentrations, after in vitro digestion were under the strongest effect of foliar Zn-Se application. On the other hand, Fe and Zn bioaccessibility (%) were under the most substantial effect of genotype. Regarding the need to increase concentrations of essential micronutrients in wheat grain, foliar Zn-Se application is a reliable and accepted agricultural practice, but to improve mineral bioaccessibility in human nutrition, foliar Zn-Se application should be combined with the most responsive genotypes. For this reason, further research on the genotype specificity of wheat regarding micronutrient bioaccessibility should be carried out.
The Unique Substance, Lidocaine and Biological Activity of the Dioscorea Species for Potential Application as a Cancer Treatment, Natural Pesticide and Product
Authors: Wonok Warin , Chaveerach Arunrat , Siripiyasing Pornnarong , Sudmoon Runglawan , Tanee Tawatchai
Published: July 2021

The six Dioscorea species, D. brevipetiolata, D. bulbifera, D. depauperata (Dd), D. glabra (Dg), D. pyrifolia and D. hamiltonii were analyzed for phytochemicals, toxicity in PBMCs, and biological activity in two cancer cell lines by MTT and comet assays, and pesticide efficiency. Via GC-MS, lidocaine was found to be the predominant compound in two of the studied species. To confirm the systematics, lidocaine was also found in lower amounts in 11 species. The MTT assay showed no toxicity in all six of the studied species. The comet assay showed the key result that the ethanol extracts of Dd and Dg violently broke DNA into pieces. Biological activity of these two species’ extracts showed toxicity on HepG2 and no effects on HCT-116. The water extracts of Dd and Dg, applied to Brassica chinensis showed high efficiency as a bioprotectant. In summary, lidocaine seems to be the predominant identifying compound of the genus Dioscorea in Thailand, which is useful in systematics. At least the two species, Dd and Dg, may be used for human hepatocyte cancer treatment and as an alternative pesticide for economically important vegetables. Dioscorea species containing lidocaine or extracted lidocaine have promise for natural product creation.
Abiotic Stress Tolerance of Coastal Accessions of a Promising Forage Species, Trifolium fragiferum
Authors: Andersone-Ozola Una , Jēkabsone Astra , Purmale Līva , Romanovs Māris , Ievinsh Gederts
Published: July 2021

Crop wild relatives are valuable as a genetic resource to develop new crop cultivars, better adapted to increasing environmental heterogeneity and being able to give high quality yields in a changing climate. The aim of the study was to evaluate the tolerance of different accessions of a crop wild relative, Trifolium fragiferum L., from coastal habitats of the Baltic Sea to three abiotic factors (increased soil moisture, trampling, cutting) in controlled conditions. Seeds from four accessions of T. fragiferum, collected in the wild, were used for experiments, and cv. ‘Palestine’ was used as a reference genotype. Plants were cultivated in asymbiotic conditions of soil culture. Treatments were performed in a quantifiable way, with three gradations for soil moisture (optimum, waterlogged, flooded) and four gradations for both trampling and cutting. All accessions had relatively high tolerance against increased soil moisture, trampling, and cutting, but significant accession-specific differences in tolerance to individual factors were clearly evident, indicating that the studied wild accessions represented different ecotypes of the species. Several wild accessions of T. fragiferum showed stress tolerance-related features superior to these of cv. ‘Palestine’, but TF1 was the most tolerant accession, with a very high score against both waterlogging and cutting, and a high score against trampling.
Synergy between Phenoxy and CSR Tougheners on the Fracture Toughness of Highly Cross-Linked Epoxy-Based Composites
Authors: Van Velthem Pascal , Gabriel Sarah , Pardoen Thomas , Bailly Christian , Ballout Wael
Published: July 2021

A remarkable synergistic increase in fracture toughness by 130% is demonstrated for a CFRP high performance epoxy composite when adding an equal weight combination of phenoxy thermoplastic and core-shell rubber (CSR) toughening agents, as compared to a single toughener at a comparable total concentration of around 10 wt%. The dual-toughened matrix exhibits an unusual morphological arrangement of the two toughener agents. The interlaminar shear strength of the composites is also synergistically improved by about 75% as compared to the reference while the compression modulus reduction and viscosity increase are significantly smaller than for the single phenoxy toughened system. A partial filtering of the CSR particles by the dense CF fabric during pre-pregging leads to a less than optimum CSR dispersion in the composites, showing that the synergy can be further optimized, possibly to the same level as the unreinforced systems.
Review: Sensors for Biosignal/Health Monitoring in Electronic Skin
Authors: Oh Hyeon , Lee Chung , Kim Na , An Taechang , Kim Geon
Published: July 2021

Skin is the largest sensory organ and receives information from external stimuli. Human body signals have been monitored using wearable devices, which are gradually being replaced by electronic skin (E-skin). We assessed the basic technologies from two points of view: sensing mechanism and material. Firstly, E-skins were fabricated using a tactile sensor. Secondly, E-skin sensors were composed of an active component performing actual functions and a flexible component that served as a substrate. Based on the above fabrication processes, the technologies that need more development were introduced. All of these techniques, which achieve high performance in different ways, are covered briefly in this paper. We expect that patients’ quality of life can be improved by the application of E-skin devices, which represent an applied advanced technology for real-time bio- and health signal monitoring. The advanced E-skins are convenient and suitable to be applied in the fields of medicine, military and environmental monitoring.
Application of Chitosan/Alginate Nanocomposite Incorporated with Phycosynthesized Iron Nanoparticles for Efficient Remediation of Chromium
Authors: Almutairi Fahad , El Rabey Haddad , Alalawy Adel , Salama Alzahraa , Tayel Ahmed , Mohammed Ghena , Aljohani Meshari , Keshk Ali , Abbas Nasser , Zayed Mohamed
Published: July 2021

Biopolymers and nanomaterials are ideal candidates for environmental remediation and heavy metal removal. As hexavalent chromium (Cr6+) is a hazardous toxic pollutant of water, this study innovatively aimed to synthesize nanopolymer composites and load them with phycosynthesized Fe nanoparticles for the full Cr6+ removal from aqueous solutions. The extraction of chitosan (Cht) from prawn shells and alginate (Alg) from brown seaweed (Sargassum linifolium) was achieved with standard characteristics. The tow biopolymers were combined and cross-linked (via microemulsion protocol) to generate nanoparticles from their composites (Cht/Alg NPs), which had a mean diameter of 311.2 nm and were negatively charged (−23.2 mV). The phycosynthesis of iron nanoparticles (Fe-NPs) was additionally attained using S. linifolium extract (SE), and the Fe-NPs had semispherical shapes with a 21.4 nm mean diameter. The conjugation of Cht/Alg NPs with SE-phycosynthesized Fe-NPs resulted in homogenous distribution and stabilization of metal NPs within the polymer nanocomposites. Both nanocomposites exhibited high efficiency as adsorbents for Cr6+ at diverse conditions (e.g., pH, adsorbent dose, contact time and initial ion concentration) using batch adsorption evaluation; the most effectual conditions for adsorption were a pH value of 5.0, adsorbent dose of 4 g/L, contact time of 210 min and initial Cr6+ concentration of 75 ppm. These factors could result in full removal of Cr6+ from batch experiments. The composited nanopolymers (Cht/Alg NPs) incorporated with SE-phycosynthesized Fe-NPs are strongly recommended for complete removal of Cr6+ from aqueous environments.
Lignin Inter-Diffusion Underlying Improved Mechanical Performance of Hot-Pressed Paper Webs
Authors: Mattsson Amanda , Joelsson Tove , Miettinen Arttu , Ketoja Jukka A. , Pettersson Gunilla , Engstrand Per
Published: July 2021

Broader use of bio-based fibres in packaging becomes possible when the mechanical properties of fibre materials exceed those of conventional paperboard. Hot-pressing provides an efficient method to improve both the wet and dry strength of lignin-containing paper webs. Here we study varied pressing conditions for webs formed with thermomechanical pulp (TMP). The results are compared against similar data for a wide range of other fibre types. In addition to standard strength and structural measurements, we characterise the induced structural changes with X-ray microtomography and scanning electron microscopy. The wet strength generally increases monotonously up to a very high pressing temperature of 270 °C. The stronger bonding of wet fibres can be explained by the inter-diffusion of lignin macromolecules with an activation energy around 26 kJ mol−1 after lignin softening. The associated exponential acceleration of diffusion with temperature dominates over other factors such as process dynamics or final material density in setting wet strength. The optimum pressing temperature for dry strength is generally lower, around 200 °C, beyond which hemicellulose degradation begins. By varying the solids content prior to hot-pressing for the TMP sheets, the highest wet strength is achieved for the completely dry web, while no strong correlation was observed for the dry strength.
Backbone Effects on the Thermoelectric Properties of Ultra-Small Bandgap Conjugated Polymers
Authors: Xie Dexun , Xiao Jing , Li Quanwei , Liu Tongchao , Xu Jinjia , Shao Guang
Published: July 2021

Conjugated polymers with narrower bandgaps usually induce higher carrier mobility, which is vital for the improved thermoelectric performance of polymeric materials. Herein, two indacenodithiophene (IDT) based donor–acceptor (D-A) conjugated polymers (PIDT-BBT and PIDTT-BBT) were designed and synthesized, both of which exhibited low-bandgaps. PIDTT-BBT showed a more planar backbone and carrier mobility that was two orders of magnitude higher (2.74 × 10−2 cm2V−1s−1) than that of PIDT-BBT (4.52 × 10−4 cm2V−1s−1). Both exhibited excellent thermoelectric performance after doping with 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane, where PIDTT-BBT exhibited a larger conductivity (0.181 S cm−1) and a higher power factor (1.861 μW m−1 K−2) due to its higher carrier mobility. The maximum power factor of PIDTT-BBT reached 4.04 μW m−1 K−2 at 382 K. It is believed that conjugated polymers with a low bandgap are promising in the field of organic thermoelectric materials.
Comparative Study of the Properties of Wood Flour and Wood Pellets Manufactured from Secondary Processing Mill Residues
Authors: Pokhrel Geeta , Han Yousoo , Gardner Douglas J.
Published: July 2021

The generation of secondary processing mill residues from wood processing facilities is extensive in the United States. Wood flour can be manufactured utilizing these residues and an important application of wood flour is as a filler in the wood–plastic composites (WPCs). Scientific research on wood flour production from mill residues is limited. One of the greatest costs involved in the supply chain of WPCs manufacturing is the transportation cost. Wood flour, constrained by low bulk densities, is commonly transported by truck trailers without attaining allowable weight limits. Because of this, shipping costs often exceed the material costs, consequently increasing raw material costs for WPC manufacturers and the price of finished products. A bulk density study of wood flour (190–220 kg/m3) and wood pellets (700–750 kg/m3) shows that a tractor-trailer can carry more than three times the weight of pellets compared to flour. Thus, this study focuses on exploring the utilization of mill residues from four wood species in Maine to produce raw materials for manufacturing WPCs. Two types of raw materials for the manufacture of WPCs, i.e., wood flour and wood pellets, were produced and a study of their properties was performed. At the species level, red maple 40-mesh wood flour had the highest bulk density and lowest moisture content. Spruce-fir wood flour particles were the finest (dgw of 0.18 mm). For all species, the 18–40 wood flour mesh size possessed the highest aspect ratio. Similarly, on average, wood pellets manufactured from 40-mesh particles had a lower moisture content, higher bulk density, and better durability than the pellets from unsieved wood flour. Red maple pellets had the lowest moisture content (0.12%) and the highest bulk density (738 kg/m3). The results concluded that the processing of residues into wood flour and then into pellets reduced the moisture content by 76.8% and increased the bulk density by 747%. These material property parameters are an important attempt to provide information that can facilitate the more cost-efficient transport of wood residue feedstocks over longer distances.
Binary Green Blends of Poly(lactic acid) with Poly(butylene adipate-co-butylene terephthalate) and Poly(butylene succinate-co-butylene adipate) and Their Nanocomposites
Authors: Coiai Serena , Di Lorenzo Maria Laura , Cinelli Patrizia , Righetti Maria Cristina , Passaglia Elisa
Published: July 2021

Poly(lactic acid) (PLA) is the most widely produced biobased, biodegradable and biocompatible polyester. Despite many of its properties are similar to those of common petroleum-based polymers, some drawbacks limit its utilization, especially high brittleness and low toughness. To overcome these problems and improve the ductility and the impact resistance, PLA is often blended with other biobased and biodegradable polymers. For this purpose, poly(butylene adipate-co-butylene terephthalate) (PBAT) and poly(butylene succinate-co-butylene adipate) (PBSA) are very advantageous copolymers, because their toughness and elongation at break are complementary to those of PLA. Similar to PLA, both these copolymers are biodegradable and can be produced from annual renewable resources. This literature review aims to collect results on the mechanical, thermal and morphological properties of PLA/PBAT and PLA/PBSA blends, as binary blends with and without addition of coupling agents. The effect of different compatibilizers on the PLA/PBAT and PLA/PBSA blends properties is here elucidated, to highlight how the PLA toughness and ductility can be improved and tuned by using appropriate additives. In addition, the incorporation of solid nanoparticles to the PLA/PBAT and PLA/PBSA blends is discussed in detail, to demonstrate how the nanofillers can act as morphology stabilizers, and so improve the properties of these PLA-based formulations, especially mechanical performance, thermal stability and gas/vapor barrier properties. Key points about the biodegradation of the blends and the nanocomposites are presented, together with current applications of these novel green materials.
Effect of Manufacturing on the Transverse Response of Polymer Matrix Composites
Authors: Shah Sagar P. , Maiarù Marianna
Published: July 2021

The effect of residual stress build-up on the transverse properties of thermoset composites is studied through direct and inverse process modeling approaches. Progressive damage analysis is implemented to characterize composite stiffness and strength of cured composites microstructures. A size effect study is proposed to define the appropriate dimensions of Representative Volume Elements (RVEs). A comparison between periodic (PBCs) and flat (FBCs) boundary conditions during curing is performed on converged RVEs to establish computationally efficient methodologies. Transverse properties are analyzed as a function of the fiber packing through the nearest fiber distance statistical descriptor. A reasonable mechanical equivalence is achieved for RVEs consisting of 40 fibers. It has been found that process-induced residual stresses and fiber packing significantly contribute to the scatter in composites transverse strength. Variation of ±5% in average strength and 18% in standard deviation are observed with respect to ideally cured RVEs that neglect residual stresses. It is established that process modeling is needed to optimize the residual stress state and improve composite performance.
Development of Structural Insulated Panels Made from Wood-Composite Boards and Natural Rubber Foam
Authors: Thongcharoen Nussalin , Khongtong Sureurg , Srivaro Suthon , Wisadsatorn Supanit , Chub-uppakarn Tanan , Chaowana Pannipa
Published: July 2021

An experimental study was carried out to develop and examine the properties of a new type of structural insulated panel (SIP). SIP prototypes conducted from this research consisted of insulated foam manufactured from natural rubber filled with wood particles as the core layer and three kinds of commercial wood-composite boards (plywood, cement particleboard, and fiber-cement board) as the surface layers. Polyurethane was used as an adhesive bond between the surface and the core layer. This preformed panel was placed into a clamping device and compressed until adhesive curing was achieved. The physical and mechanical properties of the SIP prototypes were consequently evaluated. The test results indicated that the types of surface layer materials played a significant effect on the SIP properties. The SIP covered with cement particleboard and fiber-cement board revealed high mechanical properties and high water resistance. The SIP prototype covered with plywood showed desirable properties (such as low density, high resistance of screw withdrawal, and low thermal transmittance). However, high water absorption and low fire resistance were drawbacks of the SIP covered with plywood. These properties should be improved.
Between Sea and Land: Geographical and Literary Marginality in the Conversion of Medieval Frisia
Authors: Cusack Carole M.
Published: July 2021

Ancient and medieval Frisia was an ethno-linguistic entity far larger than the modern province of Friesland, Netherlands. Water outweighed land over its geographical extent, and its marginal political status, unconquered by the Romans and without the feudal social structure typical of the Middle Ages, made Frisia independent and strange to its would-be conquerors. This article opens with Frisia’s encounters with Rome, and its portrayal in Latin texts as a wretched land of water-logged beggars, ultimately unworthy of annexation. Next, the early medieval conflict between the Frisians and the Danes/Geats, featured in Beowulf and other epic fragments, is examined. Pagan Frisia became of interest during Frankish territorial expansion via a combination of missionary activity and warfare from the seventh century onward. The vitae of saints Willibrord, Boniface, Liudger and Wulfram provide insights into the conversion of Frisia, and the resistance to Christianity and Frankish overlordship of Radbod, its last Pagan king. It is contended that the watery terrain and distinctive culture of Frisia (pastoralism, seafaring, Pagan religion) as noted in ancient and medieval texts rendered it “other” to politically centralized entities such as Rome and Francia. Frisia was eventually tamed and integrated through conversion to Christianity and absorption into Francia after the death of Radbod.
An Adaptive Offset-Tracking Method Based on Deformation Gradients and Image Noises for Mining Deformation Monitoring
Authors: Zhao Gang , Wang Liuyu , Deng Kazhong , Wang Maomei , Xu Yi , Zheng Meinan , Luo Qing
Published: July 2021

The offset-tracking method (OTM) utilizing SAR image intensity can detect large deformations, which makes up for the inability of interferometric synthetic aperture radar (InSAR) technology in large mining deformation monitoring, and has been widely used. Through lots of simulation experiments, it was found that the accuracy of OTM is associated with deformation gradients and image noises in the cross-correlation window (CCW), so CCW sizes should be selected reasonably according to deformation gradients and noise levels. Based on the above conclusions, this paper proposes an adaptive CCW selection method based on deformation gradients and image noises for mining deformation monitoring, and this method considers influences of deformation gradients and image noises on deformations to select adaptive CCWs. In consideration of noise influences on offset-tracking results, smaller CCWs are selected for large deformation gradient areas, and larger CCWs are selected for small deformation gradient areas. For some special areas, special CCWs are selected for offset-tracking. The proposed method is implemented to simulation and real experiments, and the experiment results demonstrate that the proposed method with high reliability and effectiveness can significantly improve the accuracy of OTM in mining deformation monitoring.
GPS-Based Multi-Temporal Variation in Precipitable Water over the Territory of Poland
Authors: Araszkiewicz Andrzej , Kiliszek Damian , Mierzwiak Michał , Nowak Da Costa Joanna , Szołucha Marcin
Published: July 2021

An increase in temperature causes higher evaporation of water from water bodies; consequently, the water content in the atmosphere also increases. The precipitable water (PW), as the water content in the atmospheric air column, is therefore an important parameter to consider when studying climate change. The aim of this study was to analyse multi-annual precipitable water data derived from a dense Global Navigational Satellite Systems (GNSS) network. Twelve years of observations from over a hundred ASG-EUPOS stations were used to estimate changes in precipitation water values over Poland. The data were validated by comparison with the available radio-sounding data. The analysis of the GPS-based PW values showed an upward trend in the PW value of 0.078 mm/year. The spatio-temporal distribution of the mean PW values and their fluctuations over the years were studied and visualised in the form of maps. The results are congruent with the fact that Poland lies on the border of influence of both continental and oceanic climates. Our results are also consistent with other climate research concerning this region.
Exploiting Capture Diversity for Performance Enhancement of ALOHA-Based Multi-Static Backscattering Systems in the 6G Perspective
Authors: Valentini Roberto , Di Marco Piergiuseppe , Santucci Fortunato
Published: July 2021

In this paper, we consider the emerging context of ALOHA-based multi-static backscattering communication systems. By assuming an architecture consisting of a set of passive backscattering nodes, an illuminator, and a set of spatially dislocated receivers, we firstly propose a cross-layer framework for performance analysis. The model jointly accounts for the shared wireless channel, including fading and capture effect, and channel contention strategy, which is regulated by a Framed Slotted ALOHA protocol. Furthermore, based on the inherent macroscopic diversity offered by the multi-static settings, we introduce the concept of capture diversity, which is shown to enable multiple packet detection in slots with multiple transmissions. In order to characterize the multiple access interference and approximate the capture probabilities, we enforce a log-normal approximation of the inverse Signal-to-Interference Ratio that relies on moment matching. Numerical results show the impact of deployment scenarios and the relative positions of illuminator, backscattering nodes, and receivers on the system normalized throughput. We show how the number of detection points impacts the system performance under various channel conditions. Moreover, the accuracy of the proposed approximation rationale is validated via Monte Carlo simulations. Finally, we analyze the optimal frame length in the presence of capture diversity.
Deconstructing Commercial Wearable Technology: Contributions toward Accurate and Free-Living Monitoring of Sleep
Authors: Rentz Lauren E. , Ulman Hana K. , Galster Scott M.
Published: July 2021

Despite prolific demands and sales, commercial sleep assessment is primarily limited by the inability to “measure” sleep itself; rather, secondary physiological signals are captured, combined, and subsequently classified as sleep or a specific sleep state. Using markedly different approaches compared with gold-standard polysomnography, wearable companies purporting to measure sleep have rapidly developed during recent decades. These devices are advertised to monitor sleep via sensors such as accelerometers, electrocardiography, photoplethysmography, and temperature, alone or in combination, to estimate sleep stage based upon physiological patterns. However, without regulatory oversight, this market has historically manufactured products of poor accuracy, and rarely with third-party validation. Specifically, these devices vary in their capacities to capture a signal of interest, process the signal, perform physiological calculations, and ultimately classify a state (sleep vs. wake) or sleep stage during a given time domain. Device performance depends largely on success in all the aforementioned requirements. Thus, this review provides context surrounding the complex hardware and software developed by wearable device companies in their attempts to estimate sleep-related phenomena, and outlines considerations and contributing factors for overall device success.
Can Intraoperative Intra-Articular Loads Predict Postoperative Knee Joint Laxity Following Total Knee Arthroplasty? A Cadaver Study with Smart Tibial Trays
Authors: Shah Darshan S. , Taylan Orçun , Verstraete Matthias , Berger Pieter , Vandenneucker Hilde , Scheys Lennart
Published: July 2021

Ligament balancing during total knee arthroplasty (TKA) often relies on subjective surgeon experience. Although instrumented tibial trays facilitate an objective assessment of intraoperative joint balance through quantification of intra-articular joint loads, postoperative clinical assessment of joint balance relies on passive stress tests quantifying varus–valgus joint laxity. This study aimed at correlating the intraoperative and postoperative metrics used to assess joint balance while also comparing joint loads obtained during passive assessment and active functional motions. Four experienced surgical fellows were assigned a fresh-frozen lower limb each to plan and perform posterior-stabilised TKA. An instrumented tibial insert measured intraoperative intra-articular loads. Specimens were then subjected to passive flexion–extension, open-chain extension, active squatting, and varus–valgus laxity tests on a validated knee simulator. Intra-articular loads were recorded using the instrumented insert and tibiofemoral kinematics using an optical motion capture system. A negative correlation was observed between mean intraoperative intra-articular loads and corresponding mean postoperative tibial abduction angle during laxity tests (medial: R = −0.93, p = 0.02; lateral: R = −0.88, p = 0.04); however, this was not observed for each specimen. Peak intra-articular load distribution for active squatting was lateral-heavy, contrasting to the medial-heavy distribution observed in passive intraoperative measurements, for all specimens. These aspects should be given due consideration while assessing intraoperative and postoperative joint stability following TKA.
Needs, Requirements and a Concept of a Tool Condition Monitoring System for the Aerospace Industry
Authors: Bombiński Sebastian , Kossakowska Joanna , Nejman Mirosław , Haber Rodolfo E. , Castaño Fernando , Fularski Robert
Published: July 2021

In this paper, we describe the needs and specific requirements of the aerospace industry in the field of metal machining; specifically, the concept of an edge-computing-based production supervision system for the aerospace industry using a tool and cutting process condition monitoring system. The new concept was developed based on experience gained during the implementation of research projects in Poland’s Aviation Valley at aerospace plants such as Pratt & Whitney and Lockheed Martin. Commercial tool condition monitoring (TCM) and production monitoring systems do not effectively meet the requirements and specificity of the aerospace industry. The main objective of the system is real-time diagnostics and sharing of data, knowledge, and system configurations among technologists, line bosses, machine tool operators, and quality control. The concept presented in this paper is a special tool condition monitoring system comprising a three-stage (natural wear, accelerated wear, and catastrophic tool failure) set of diagnostic algorithms designed for short-run machining and aimed at protecting the workpiece from damage by a damaged or worn tool.
New Distributed Fibre Optic 3DSensor with Thermal Self-Compensation System: Design, Research and Field Proof Application Inside Geotechnical Structure
Authors: Bednarski Łukasz , Sieńko Rafał , Grygierek Marcin , Howiacki Tomasz
Published: July 2021

Thanks to the dynamic development of advanced building technologies as well as the growing awareness, experience and responsibilities of engineers, structural health monitoring systems (SHM) are increasingly applied in civil engineering and geotechnical applications. This is also facilitated by the construction law and standard requirements, e.g., the observation method for geotechnical structures described in the Eurocode 7. Still, the most common approach is to apply spot sensors in selected points of the structure to validate theoretical models, numerical simulations and support technical assessments by involving statistic and approximation methods. The main limitation of spot sensing is the inability to detect localized damages such as cracks, fractures, sinkholes or shear planes. Thus, such analysis is subject to considerable uncertainty, especially within geotechnical structures, characterized by random mechanical parameters that change with location, but also over time. Another approach is based on distributed fibre optic sensors (DFOS), which are finding a growing acceptance in laboratory and field projects, overcoming limitations of conventional measurements. The design and applications of new DFOS dedicated for 3D displacement sensing are described hereafter in the article. The novelty of the presented solution lies in several features, including design, application, production technology and materials. This article is focused on the operational rules governing DFOS and proving their effectiveness in laboratory and geotechnical field applications.
Masculine Gender Norms and Adverse Workplace Safety Outcomes: The Role of Sexual Orientation and Risky Safety Behaviors
Authors: Austin Christopher , Probst Tahira M.
Published: July 2021

The current study tested the proposition that higher conformity to masculine gender norms (CMGN) is associated with increased safety risk-taking behaviors, which in turn are related to more accidents, injuries, and higher levels of accident underreporting. Additionally, we proposed that sexual minority status would exacerbate the relationship between conformity to masculine gender norms and safety risk-taking behaviors. Using two-wave lagged survey data obtained from N = 403 working adults, findings supported the proposed moderated-mediation model. High conformity to masculine gender norms was associated with increased safety risk-taking behaviors, accidents, injuries, and accident underreporting. Moreover, the relationship between CMGN and safety-risk-taking behaviors was stronger among homosexual men compared to their heterosexual counterparts. Additionally, safety risk-taking behaviors mediated the relationship between CMGN and safety outcomes. Finally, this indirect effect was stronger among homosexual men. Combined, these findings suggest that CMGN adversely impacts employee safety outcomes via safety-related risk-taking. We discuss these implications as well as the need for interventions designed to decrease risk taking behaviors in light of CMGN, particularly among sexual minorities.
The Role of Human Support on Engagement in an Online Depression Prevention Program for Youth
Authors: Rogers Julia , Gladstone Tracy , Van Voorhees Benjamin , Bunge Eduardo L.
Published: July 2021

Background: Depression is a significant public health problem for adolescents. The goal of this study was to evaluate the moderating role of human support in an online depression prevention program on both depression outcomes and overall engagement with the intervention. CATCH-IT is an Internet-based depression prevention program that has been shown to reduce symptoms for adolescents who report elevated depression symptom scores, compared to a health education (HE) control group. Participants in the CATCH-IT arm received human support (e.g., motivational interviewing, completed contacts). This study analyzes the moderating role of human support on depressive outcomes and engagement, and examines if engagement predicts depression outcomes. Methods: This secondary analysis consists of a randomized controlled trial for adolescents assigned to the CATCH-IT group. Mixed effects modeling, general linear models, and an exploratory multiple linear regression were used to explore the moderating relationship of human support between intervention and overall engagement. Study variables included depression outcomes (e.g., Center for Epidemiological Studies Depression Scale (CESD)), engagement components (e.g., modules completed, time on the site, and characters typed) and human support (e.g., motivational interviews and completed contacts.) Results: Results showed no significant relationship between contacts, motivational interviews, and depression scores. However, motivational interviews increased engagement with the intervention, such that those who received more motivational interviews completed significantly more modules, spent more time on the site, and typed more characters (p < 0.05). The number of contacts increased engagement with the intervention, and those who received more contacts spent more time on the site and typed more characters (p < 0.05). Exploratory multiple linear regression modeling demonstrated that male, African American/Black, and Hispanic/Latinx users were less engaged compared to other users. Lastly, engagement was not a significant predictor of depression outcomes (p > 0.05). Conclusions: The efficacy of CATCH-IT is not better explained by the degree to which participants received doses of human support from providers during the use of this online intervention. This may reveal the high potential of effective online interventions without the blended integration of human support for adolescents. To increase engagement of adolescents with an online depression prevention program, human support may be more efficient when utilizing MI rather than technical support.
A Glimpse into the Diverse Cellular Immunity against SARS-CoV-2
Authors: Chang Cheng-Wei , Liu Yuchen , Jiao Cheng , Liu Hongwei , Gong Jie , Chen Xiaochuan , Chang Lung-Ji
Published: July 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific cellular immune response has been shown to play a critical role in preventing severe illness or death in patients infected with SARS-CoV-2 or its variants. Given the multiple T-cell epitopes shared by wild-type virus and its variants, we hypothesized that vaccines that target multiple T-cell epitopes of SARS-CoV-2 may provide a “universal protection” against the wild-type virus as well as its variants, even the heavily mutated ones. To test this, we assessed SARS-CoV-2-specific T-cell precursors in healthy individuals using overlapping peptide pools of SARS-CoV-2 structural and functional proteins, including spike (S), membrane (M), envelope (E), nucleocapsid (N), and protease (P) proteins as target antigens. Diverse T-cell precursor frequencies specific to these viral antigens were detected in healthy individuals, including high, medium, low, and no responders. This was further confirmed by efficient induction of anti-SARS-CoV-2 T-cell immune responses using ex vivo dendritic cell (DC)/T cell coculture. The results demonstrated T-cell responses consistent with the precursor frequencies of each of the individuals tested. Importantly, the combination of all five viral peptide pools induced the strongest cellular immune response, and further, after a DC-peptides re-stimulation, even the no responders developed an increased anti-viral T-cell response. These analyses recapitulate the presence of a broad anti-SARS-CoV-2 cellular immunity even in an immune naïve population, which could be enhanced by antigen presenting cells presenting the overlapping antigenic peptides. Given the critical role of cellular immunity in COVID-19 protection, these results have important implications for vaccine design and immunotherapy in fighting SARS-CoV-2 and its variants.
COVID-19 Vaccine Acceptability and Its Determinants in Mozambique: An Online Survey
Authors: Dula Janeth , Mulhanga Alexandre , Nhanombe Armindo , Cumbi Laurentino , Júnior António , Gwatsvaira Joe , Fodjo Joseph Nelson Siewe , Faria de Moura Villela Edlaine , Chicumbe Sérgio , Colebunders Robert
Published: July 2021

A high worldwide SARS-CoV-2 vaccine coverage must be attained to stop the COVID-19 pandemic. In this study, we assessed the level of willingness of Mozambicans to be vaccinated against COVID-19. Data were collected between 11 and 20 March 2021, through a self-administered online survey. Of the 1878 respondents, 30.1% were healthcare workers, 58.3% were aged between 18 and 35 years, 60% were male, and 38.5% were single. Up to 43% had been tested for COVID-19 and 29% had tested positive. Overall vaccine acceptability was 71.4% (86.6% among healthcare workers, 64.8% among other respondents; p < 0.001). Reasons for vaccine hesitancy included: fear of vaccine side effects (29.6%) and the belief that the vaccine is not effective (52%). The acceptability of the SARS-CoV-2 vaccine increased with increasing vaccine efficacy. Using logistic regression, determinants for acceptability of the vaccine were: older age, a past COVID-19 test, a concern of becoming (re)infected by COVID-19, having a chronic disease, and considering vaccination important for personal and community health. In conclusion, vaccine acceptability in Mozambique was relatively high among healthcare workers but significantly lower in the rest of the population. This suggests that there is a need to educate the general population about SARS-CoV-2 vaccination and its importance.