bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehensive analysis of ceRNA Networks in UCEC: Prognostic and therapeutic implications
Authors: Fan Li , Lan Mengqiu , Wei Xiaohua , Wei Lili , Yang Liuhong , Nong Liuying , Wei Jiajia , Li Jingjing , Huang Wenjie
Published: January 2025

Endometrial cancer (UCEC) is the most prevalent gynecological malignancy in high-income countries, and its incidence is rising globally. Although early-stage UCEC can be treated with surgery, advanced cases have a poor prognosis, highlighting the need for effective molecular biomarkers to improve diagnosis and prognosis. In this study, we analyzed mRNA and miRNA sequencing data from UCEC tissues and adjacent non-cancerous tissues from the TCGA database. Differential expression analysis was conducted using the DESeq2 package, identifying differentially expressed lncRNAs, miRNAs, and mRNAs (DElncRNAs, DEmiRNAs, and DEmRNAs). Key molecules were screened using LASSO regression, and a ceRNA network was constructed by predicting lncRNA-miRNA and miRNA-mRNA interaction, which were visualized with Cytoscape. Functional enrichment analysis elucidated the roles and mechanisms of the network. The prognostic potential of the identified RNAs was assessed through survival and Cox regression analyses, while methylation and immune infiltration analyses explored regulatory mechanisms and immune interactions. We identified a prognostic lncRNA-miRNA-mRNA ceRNA network in UCEC, centered on the CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3 axis. Survival analyses confirmed the prognostic significance of this network, with univariate Cox regression demonstrating a strong association between its aberrant expression and overall prognosis in UCEC. However, multivariate Cox regression suggested that other clinical factors may modulate this relationship. Methylation analysis revealed low methylation levels of IGF2BP3, possibly contributing to its overexpression. Furthermore, immune infiltration studies highlighted significant correlations between CDKN2B-AS1, IGF2BP3, and multiple immune cell types, suggesting that this axis regulates the tumor immune microenvironment. These findings suggest that the CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3 axis is a key regulatory element in UCEC and a potential therapeutic target.
Prognostic value of immune biomarkers in melanoma loco-regional metastases
Authors: Hugdahl Emilia , Aziz Sura , Klingen Tor A. , Akslen Lars A.
Published: January 2025

The prognosis for patients with melanoma loco-regional metastases is very heterogenous. Adjuvant PD-L1-inhibitors have improved clinical outcome for this patient group, but the prognostic impact of tumour PD-L1 expression and number of tumour infiltrating lymphocytes (TILs) is still largely unknown. Here, we investigated the impact on survival for CD3, CD8, FOXP3 and PD-L1 TIL counts and tumour PD-L1 expression in melanoma loco-regional metastases. In a patient series of loco-regional metastases from nodular melanomas (n = 78; n = 26 skin metastases, n = 52 lymph node metastases), expression of PD-L1 in tumour cells and the number of CD3, CD8, FOXP3 and PD-L1 positive TILs were determined by immunohistochemistry on tissue microarray (TMA) slides. Due to limited tumour tissue in the paraffin blocks, 67 of the 78 cases were included for tissue microarrays. Low FOXP3 TIL count and negative tumour PD-L1 expression (cut off 1%) were both significantly associated with reduced survival in lymph node metastases. Low FOXP3 TIL count was significantly associated with low CD8, CD3 and PD-L1 TIL counts. Negative tumour PD-L1 expression was significantly associated with low CD8 and PD-L1 TIL count, large lymph node metastasis tumour size and presence of necrosis in lymph node metastases. Our findings demonstrate for the first time the negative prognostic value of low FOXP3 TIL count and confirm a negative prognostic value of negative tumour PD-L1 expression in melanoma lymph node metastases.
A novel classification method for balance differences in elite versus expert athletes based on composite multiscale complexity index and ranking forests
Authors: Cheng Yuqi , Wu Dawei , Wu Ying , Guo Youcai , Cui Xinze , Zhang Pengquan , Gao Jie , Fu Yanming , Wang Xin
Published: January 2025

Balance is crucial for various athletic tasks, and accurately assessing balance ability among elite athletes using simple and accessible measurement methods is a significant challenge in sports science. A common approach to balance assessment involves recording center of pressure (CoP) displacements using force platforms, with various indicators proposed to distinguish subtle balance differences. However, these indicators have not reached a consensus, and it remains unclear whether these analyses alone can fully explain the complex interactions of postural control. In this study, we investigated four parameters related to balance control—anterior-posterior (AP) displacement, medial-lateral (ML) displacement, length, and tilt angle—in 13 elite athletes and 12 freestyle skiing aerial expert athletes. Data were recorded during 30-second trials on both soft and hard support surfaces, with eyes open and closed. We calculated the CMCI and used four machine learning algorithms—Logistic Regression, Support Vector Machine(SVM), Naive Bayes, and Ranking Forest—to combine these features and assess each participant’s balance ability. A classic train-test split method was applied, and the performance of different classifiers was evaluated using Receiver Operating Characteristic(ROC) analysis. The ROC results showed that traditional time-domain features were insufficient for accurately distinguishing athletes’ balance abilities, whereas CMCI performed the best overall. Among all classifiers, the combination of CMCI and Ranking Forest yielded the best performance, with a sensitivity of 0.95 and specificity of 0.35. This nonlinear, multidimensional approach appears to be highly suitable for assessing the complexity of postural control.
Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly
Authors: Bheemireddy Sneha , Sowdhamini Ramanathan , Srinivasan Narayanaswamy
Published: January 2025

Background

RNA polymerase-binding protein A (RbpA) is an actinomycetes-specific protein crucial for the growth and survival of the pathogen Mycobacterium tuberculosis. Its role is essential and influences the transcription and antibiotic responses. However, the regulatory mechanisms underlying RbpA-mediated transcription remain unknown. In this study, we employed various computational techniques to investigate the role of RbpA in the formation and dynamics of the RNA polymerase complex.

Results

Our analysis reveals significant structural rearrangements in RNA polymerase happen upon interaction with RbpA. Hotspot residues, crucial amino acids in the RbpA-mediated transcriptional regulation, were identified through our examination. The study elucidates the dynamic behavior within the complex, providing insights into the flexibility and functional dynamics of the RbpA-RNA polymerase interaction. Notably, potential allosteric mechanisms, involving the interface of subunits α1 and α2 were uncovered, shedding light on how RbpA modulates transcriptional activity.

Conclusions

Finally, potential ligands meant for the α1–α2 binding site were identified through virtual screening. The outcomes of our computational study serve as a foundation for experimental investigations into inhibitors targeting the RbpA-regulated dynamics in RNA polymerase. Overall, this research contributes valuable information for understanding the intricate regulatory networks of RbpA in the context of transcription and suggests potential avenues for the development of RbpA-targeted therapeutics.
The association of muscle weakness with functional disability in older patients with Diabetes mellitus: Measured by three different grip strength thresholds
Authors: Çavdar Sibel , Kocak Fatma Ozge Kayhan , Savas Sumru
Published: January 2025

The association of muscle weakness with poor outcomes is well defined in general older population, but there is insufficient data on the association of muscle weakness with functionality in older patients with diabetes mellitus (DM). We aimed to investigate the predictivity of muscle weakness defined as low grip strength thresholds determined by EWGSOP2, and two regional thresholds in older patients with DM for functional disability. Activities of Daily Living (ADL), Instrumental ADL (IADL), grip strength, comorbidities, anthropometric and biochemical data from outpatient clinic medical records were screened retrospectively. Low grip strength was determined by EWGSOP2, and two regional thresholds. Receiver operating characteristic (ROC) analysis, sensitivity and negative predictive values were conducted to identify the discrimination power of three different grip strength thresholds for functional disability in patients with DM. A total of 197 patients with DM and 215 controls were included. In ROC analyses, regional thresholds were with higher sensitivity and negative predictive values for functional disability in both groups. For patients with DM, regional normative thresholds predicted functional disability both for ADLs and IADLs whereas for patients without DM normative thresholds predicted ADL, and calculated thresholds predicted IADL disability. Regional normative thresholds predicted both ADL and IADL functional disability in older patients with DM.
Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer’s disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors
Authors: Guerguer Fatima Zahra , Rossafi Bouchra , Abchir Oussama , Raouf Yasir S. , Albalushi Dhabya Bakhit , Samadi Abdelouahid , Chtita Samir
Published: January 2025

Cognitive dysfunction in Alzheimer’s disease results from a complex interplay of various pathological processes, including the dysregulation of key enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and monoamine oxidase B (MAO-B). This study proposes and designs a series of novel molecules derived from 8-hydroxyquinoline (Azo-8HQ) as potential multi-target lead candidates for treating AD. An exhaustive in silico analysis was conducted, encompassing docking studies, ADMET analysis, density functional theory (DFT) studies, molecular dynamics simulations, and subsequent MM-GBSA calculations to examine the pharmacological potential of these molecules with the specific targets of interest. Out of the 63 Azo-8HQ derivatives analysed, two molecules, 14c and 17c, demonstrated strong affinities for AChE, BuChE, and MAO-B, along with favourable pharmacokinetic profiles and electronic properties. Molecular dynamics simulations confirmed the stability of these molecules within the active sites of the targets, and MM-GBSA calculations revealed low binding energies, indicating robust interactions. These findings identify molecules 14c and 17c as promising multi-target candidates for the treatment of AD, based on an in-depth computational study aimed at minimizing drug development costs and time. Future work will include the synthesis of these molecules followed by in-depth in vitro and in vivo testing to validate their potential therapeutic efficacy.
Evolution of the Danube River’s islands on the Bulgaria-Romania border over the last century
Authors: Ioana-Toroimac Gabriela , Vîrghileanu Marina
Published: January 2025

The border line between Bulgaria and Romania was established a century ago on the Danube River’s thalweg, going around islands. Over time, islands migrated; to avoid conflicts, islands located on the border line are declared neutral territory by both countries and they exit from use. In this context, the paper aims to draw conclusions on the spatial dynamics of the Danube River’s sandy islands along the Bulgaria-Romania border. This approach is mostly a GIS work on various documents over the last century, with interpretations specific to fluvial geomorphology. Our paper showed patterns of evolution of islands. (i) The trajectory of half of the islands can be reconstituted over the last century (i.e., merging with each other and/or migrated). The trajectory of the other half of the islands can be redrawn over the last half of the century. The form and dimensions of islands did not statistically change at any time scale. (ii) At the scale of the last decades, we noticed the slow formation of bars by lee deposition due to sediment excess and then migration of alluvial bars until merging with an island or with the bank, followed by stabilization due to vegetation recruitment. (iii) Islands and their bars migrated on the countries’ border line, but their evolution is slow in time. Our paper invites national authorities to periodically inventory the geomorphological trajectory of islands and bars, but to transfer the decision-making process for stable islands at local scale in order to put them into green use with benefits for local communities.
AutoPVPrimer: A comprehensive AI-Enhanced pipeline for efficient plant virus primer design and assessment
Authors: Ghorbani Abozar , Rostami Mahsa , Ashrafi-Dehkordi Elham , Guzzi Pietro Hiram
Published: January 2025

Plant viruses pose a significant threat to global agriculture and require efficient tools for their timely detection. We present AutoPVPrimer, an innovative pipeline that integrates artificial intelligence (AI) and machine learning to accelerate the development of plant virus primers. The pipeline uses Biopython to automatically retrieve different genomic sequences from the NCBI database to increase the robustness of the subsequent primer design. The design_primers_with_tuning module uses a random forest classifier that optimizes parameters and provides flexibility for different experimental conditions. Quality control measures, including the evaluation of poly-X content and melting temperature, increase primer reliability. Unique to AutoPVPrimer is the visualize_primer_dimer module, which supports the visual evaluation of primer dimers—a feature missing in other tools. Primer specificity is validated via primer BLAST, which contributes to the overall efficiency of the pipeline. AutoPVPrimer has been successfully applied to the tomato mosaic virus, proving its adaptability and efficiency. The modular design allows customization by the user and extends the applicability to different plant viruses and experimental scenarios. The pipeline represents a significant advance in primer design and provides researchers with an effective tool to accelerate molecular biology experiments. Future developments aim to extend compatibility and incorporate user feedback to consolidate AutoPVPrimer as an innovative contribution to the bioinformatics toolbox and a promising resource for the advancement of plant virology research.
Predicting the risk of bone metastases in patients with newly diagnosed prostate cancer – Development and validation of a nomogram model
Authors: Xu Wei , Zhu Guoyu , Wang Xiaoxiang , Yan Xuebing , Wang Fujun , Li Shanyi , Li Wenji
Published: January 2025

Objectives

The aim of this study was to develop and validate a nomogram model that predicts the risk of bone metastasis (BM) in a prostate cancer (PCa) population.

Methods

We retrospectively collected and analyzed the clinical data of patients with pathologic diagnosis of PCa from January 1, 2013 to December 31, 2022 in two hospitals in Yangzhou, China. Patients from the Affiliated Hospital of Yangzhou University were divided into a training set and patients from the Affiliated Clinical College of Traditional Chinese Medicine of Yangzhou University were divided into a validation set. Chi-square test, independent sample t-test, and logistic regression were used to screen key risk factors. Receiver operating characteristic (ROC) curves, c-index, calibration curves, and decision curves analysis (DCA) were used for the validation, calibration, clinical benefit assessment, and external validation of nomogram models.

Results

A total of 204 cases were collected from the Affiliated Hospital of Yangzhou University, including 64 cases diagnosed as PCa BM and 50 cases collected from the Affiliated Clinical College of Traditional Chinese Medicine of Yangzhou University, including 12 cases diagnosed as PCa BM. Results showed that history of alcohol consumption, prostate stiffness on Digital rectal examination(DRE), prostate nodules on DRE, FIB, ALP, cTx, and Gleason score were high-risk factors for BM in PCa and nomogram was established. The c-index of the final model was 0.937 (95% CI: 0.899–0.975). And the model was validated by external validation set (c-index: 0.929). The ROC curves and calibration curves showed that the nomogram had good predictive accuracy, and DCA showed that the nomogram had good clinical applicability.

Conclusions

Our study identified seven high-risk factors for BM in PCa and these factors would provide a theoretical basis for early clinical prevention of PCa BM.
Prevalence and associated factors of diabetes among adult populations of Hawassa town, southern Ethiopia: A community based cross-sectional study
Authors: Belete Getu Kassa , Sithole Hlupheka Lawrence
Published: January 2025

Introduction

Knowing the magnitude and preventable risk factors of diabetes has a significant contribution in targeted prevention intervention which ultimately ensures the existence of healthier and productive individuals in a country. Diabetes has untoward impact on health, social and economic consequences. Exploring preventable risk factors are extremely important because of their potential association and interaction with diabetes. Therefore, the aim of this study was to investigate the magnitude and modifiable risk factors of diabetes among adult populations in Hawassa town, southern Ethiopia.

Methods

A community based cross-sectional study was conducted from September, 2023 to November, 2023 among adult populations. A multi-stage sampling technique was employed to select 1,113 study participants between the ages of 20–69 years. An interviewer-administered questionnaire was used to collect data. Additionally, participants were also instructed to fast overnight, after which the standard fasting blood glucose test was conducted. A binary logistic regression model was fitted to identify independent predictors of diabetes.

Results

The overall prevalence of diabetes was 14.4% (95% Confidence Interval (CI): 12.4%, 16.4%). Being male (Adjusted Odds Ratio (AOR):2.10; 95% CI: 1.34, 3.29), being unable to read and write (AOR: 3.38; 95% CI: 1.09, 10.47), read and write (AOR: 3.38; 95% CI: 1.09, 10.47) and medium cycle (AOR 2.79; 95% CI: 1.02, 7.63) compared to college and above, consume less than 5 servings of fruits on daily base (AOR: 2.80; 95% CI: 1.18, 6.62), having ever chewed khat (AOR 6.50; 95% CI: 4.07, 10.39) and being overweight and obese (AOR: 2.43; 95% CI: 1.54, 3.83) were independently associated with diabetes mellitus (DM).

Conclusion

This study identified a high prevalence of diabetes among adults in Hawassa, driven by various risk factors. This presents an opportunity to mitigate diabetes risk through public health measures, including avoiding khat chewing, promoting healthy diets, managing overweight and obesity, implementing community-based screening, enhancing health literacy, and integrating health information into daily life.
Generating context-specific sports training plans by combining generative adversarial networks
Authors: Tan Juquan , Chen Jingwen
Published: January 2025

Personalized sports training plans are essential for addressing individual athlete needs, but traditional methods often need to integrate diverse data types, limiting adaptability and effectiveness. Existing machine learning (ML) and rule-based approaches cannot dynamically generate context-specific training programs, reducing their applicability in real-world scenarios. This study aims to develop a Generative Adversarial Network (GAN)- based framework to create context-specific training plans by integrating numeric attributes (e.g., age, heart rate) and motion features from video data. The research focuses on improving context-specific efficiency and real-time adaptability while addressing the limitations of traditional methods. The proposed GAN framework combines numeric and motion features using a generator-discriminator architecture to produce tailored training plans. The model is evaluated quantitatively through metrics like mean square error (MSE) and generation time and qualitatively through subjective ratings from athletes and coaches using a five-point Likert scale for context-specific, scientificity, applicability, and feasibility. Statistical significance is analyzed using ANOVA testing. The proposed GAN model outperforms traditional ML and rule-based methods, achieving a 22% reduction in MSE and a 45% improvement in generation time. Subjective evaluations reveal significant improvements in context-specific and applicability, with ratings averaging 4.8/5 compared to 3.9/5 for baseline models. The GAN framework effectively integrates multimodal data, demonstrating dynamic adaptability and high efficiency suitable for real-world applications. The proposed GAN-based framework advances the generation of personalized sports training plans by integrating numeric and motion data, achieving superior adaptability and efficiency. These results highlight the model’s potential for practical deployment in athletic coaching systems, addressing critical gaps in existing methodologies and offering scalable solutions for individualized training.
The physical activity and sedentary behavior among pregnant women in Macao: A cross-sectional study
Authors: Mok Ka Chon , Liu Ming , Wang Xin
Published: January 2025

Objective

The current investigation sought to elucidate the prevalence and contributing factors of sedentary behavior among pregnant women in Macao, a densely populated region characterized by a distinctive fusion of Eastern and Western cultures and a thriving global economy.

Methods

Through a cross-sectional study design, a total of 306 expectant mothers were recruited via various social media platforms and completed a sociodemographic questionnaire alongside the Chinese version of the Pregnancy Physical Activity Questionnaire.

Results

The findings revealed that sedentary activities accounted for a relatively small proportion (7.8%) of the participants’ total activity energy expenditure. Interestingly, employment status emerged as a significant determinant, with employed pregnant women exhibiting a 57.9% lower risk of being sedentary compared to their unemployed counterparts. Moreover, multiparous women (those with two or more children) were approximately 9 times more likely to meet moderate-intensity activity standards than nulliparous women.

Conclusion

These insights highlight the importance of tailoring physical activity interventions to address the specific needs and challenges faced by primiparous women and those who are unemployed during pregnancy, with a view to enhancing education on the potential hazards associated with sedentary habits and promoting active lifestyles within this unique sociocultural context.
Construction on training course and training quality evaluation index system of chronic disease medication therapy management service (MTMs) in China: A Delphi study
Authors: Cai Wenting , Yao Yao , Lei Wenpu , Li Huixin , Yan Simin , Wu Qiuhui , Wang Jian , Ge Weihong , Zhang Jinping
Published: January 2025

Objective

This study aims to construct a training course and quality evaluation index system for chronic disease Medication Therapy Management service (MTMs) that is suitable for China’s national conditions. It seeks to provide tools and a scientific foundation for assessing the quality of MTMs training.

Methods

Drawing from domestic and international literature and combining with the practice of chronic disease medication management by Chinese pharmacists, a preliminary framework for the evaluation index system was established. The Delphi method was used to solicit expert opinions, evaluate and improve the evaluation index system. Indicator weights were determined by using the Analytic Hierarchy Process (AHP).

Results

Both rounds of expert inquiry achieved a positive degree of 100% (18/18 experts). The authority coefficients (Cr) were 0.90 and 0.91 respectively. The Kendall coordination coefficients (Kendall’s W) of the second and third-level indicators for the first round of inquiry were 0.230 and 0.189, while those for the second round were 0.326 and 0.213. Finally, an MTMs training course and training quality evaluation index system was structured, comprising 3 first-level indicators, 11 second-level indicators, and 39 third-level indicators.

Conclusion

The evaluation index system constructed in this study is scientifically robust and rational, offering a foundation to standardize MTMs training practices effectively.
Multi-session tDCS over the posterior parietal cortex and associative memory
Authors: Juras Luka , Martinčević Marina , Konstantinović Uroš , Filipović Saša R. , Vranić Andrea , Bjekić Jovana
Published: January 2025

Associative memory (AM) plays a crucial role in our ability to link disparate elements of our experiences, yet it is especially vulnerable to age-related decline and pathological conditions. Non-invasive brain stimulation (NIBS), particularly transcranial direct current stimulation (tDCS), has been investigated as a potential intervention to enhance cognitive functions, including AM. Previous tDCS studies yielded inconsistent results, often due to variations in stimulation sites and protocols. Nonetheless, enough evidence suggests that tDCS over the posterior parietal cortex (PPC) can improve AM performance. This study aimed to investigate the cumulative effects of multiple anodal tDCS over the PPC on AM performance alongside item memory and verbal fluency. In a randomized sham-controlled trial, 59 healthy young adults were assigned to either anodal or sham stimulation group, receiving tDCS (1.5 mA, for 20 minutes, at P3) over three consecutive days. Memory performance was assessed at four timepoints: pretest, immediately after the first session, posttest (Day 5), and follow-up (Day 9). Although tDCS was well tolerated, the anticipated enhancement of memory performance was not observed. We interpret these findings in the light of methodological considerations and propose potential explanations for the observed results emphasizing the large between-participants variability in memory performance as a significant factor that may have hindered the detection of tDCS effects.
Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein
Authors: Qiu Qian , He Zihan , Liu Jing , Xu Huijun , Wang Jinyu , Liu Nannan , Kang Ning , Pan Shaokun , Yu Weien , Gao Zixiang , Zhang Shimei , Yang Yang , Deng Qiang , Xie Youhua , Zhang Jiming , Shen Zhongliang
Published: January 2025

Hepatitis B virus (HBV) X protein (HBx) is a key factor for regulating viral transcription and replication. We recently characterized homeobox protein MSX-1 (MSX1) as a host restriction factor that inhibits HBV gene expression and genome replication by directly binding to HBV enhancer II/core promoter (EnII/Cp) and suppressing its promoter and enhancer activities. Notably, HBx expression was observed to be repressed more drastically by MSX1 compared to other viral antigens. In this work, we report that in addition to transcriptional repression, MSX1 also post-transcriptionally downregulates HBx protein stability. Mechanistically, MSX1 induces ubiquitin-independent proteasomal degradation of HBx, which is mediated through HBx C-terminal domain. Furthermore, this effect on HBx degradation correlates with MSX1-induced upregulation of DNAJA4 and CRYAB expression. Similar to MSX1, both DNAJA4 and CRYAB promote HBx degradation and repress HBV gene expression and genome replication. In chronic hepatitis B (CHB) patients, immune active phase (IA) is associated with higher intrahepatic expression of MSX1, DNAJA4 and CRYAB, and lower serum HBV markers compared to immune tolerant (IT) phase. Finally, HBV infection is significantly suppressed by MSX1 overexpression in both NTCP-overexpressing cell and humanized liver mouse models. These results demonstrate additional and novel mechanisms of MSX1-mediated repression of HBV, and establish MSX1 as a multi-functional HBV restriction factor with therapeutic potential.
Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infection
Authors: Boccardo Santiago , Rodriguez Constanza , Gimenez Camila M. S. , Araujo Furlan Cintia L. , Abrate Carolina P. , Almada Laura , Saldivia Concepción Manuel A. , Skewes-Cox Peter , Rao Srinivasa P. S. , Mukdsi Jorge H. , Montes Carolina L. , Gruppi Adriana , Acosta Rodríguez Eva V.
Published: January 2025

Tissue-repair regulatory T cells (trTregs) comprise a specialized cell subset essential for tissue homeostasis and repair. While well-studied in sterile injury models, their role in infection-induced tissue damage and antimicrobial immunity is less understood. We investigated trTreg dynamics during acute Trypanosoma cruzi infection, marked by extensive tissue damage and strong CD8+ immunity. Unlike sterile injury models, trTregs significantly declined in secondary lymphoid organs and non-lymphoid target tissues during infection, correlating with systemic and local tissue damage, and downregulation of function-associated genes in skeletal muscle. This decline was linked to decreased systemic IL-33 levels, a key trTreg growth factor, and promoted by the Th1 cytokine IFN-γ. Early recombinant IL-33 treatment increased trTregs, type 2 innate lymphoid cells, and parasite-specific CD8+ cells at specific time points after infection, leading to reduced tissue damage, lower parasite burden, and improved disease outcome. Our findings not only provide novel insights into trTregs during infection but also highlight the potential of optimizing immune balance by modulating trTreg responses to promote tissue repair while maintaining effective pathogen control during infection-induced injury.
Estratigrafía lingüística y áreas dialectales del País Vasco con los datos de la toponimia
Authors: Abaitua Joseba K.
Published: January 2025

Se propone una estratigrafía lingüística para el País Vasco en la que el elemento vascorrománico cubre la capa latina y prerromana, sin solución de continuidad en el caso románico, pero con una clara delimitación para el arranque del estrato euskérico. Este dataría, al menos para el occidente del territorio, con seguridad a partir del siglo viii, dada su condición dialectal, pero con un muy probable adelanto a mediados del siglo vi. Las áreas dialectales son visibles sobre todo en la toponimia en euskera, aspecto con el que no se correlaciona totalmente la distribución de los principales sufijos de propiedad (-ica, -áin, -ana, -iz). Estos muestran una distribución mucho más dispar, aunque también acotable en los ejes espacial y temporal.
The Language Shift Origins of Judeo-Spanish
Authors: Şaul Mahir
Published: January 2025

This article proposes that the Judeo-Spanish language of the Sephardic Jews of the Balkans and the eastern Mediterranean involved at its origin a language shift that occurred after emigration from the Iberian Peninsula, in non-Hispanic environment; that a form of Castilian was adopted as a deliberate act and rapidly in the early period of exile, to change a prior situation of Romance language pluralism within and among the transplanted Jewish communities.
Ahoskeraren Dibertsitatea Arratia-Nerbioin (1981-2000)
Authors: Gaminde Iñaki
Published: January 2025

Lan honetan hizkuntz aldakortasunaren azterketa kuantitatiboan ohikoak ez diren teknikak aplikatzean lortutako emaitzak erakusten dira. Alde batetik, aztertutako materialak ahozko testu libreak izan dira eta, beste alde batetik, aldagai dikotomikoak erabili beharrean aztertu diren moldeen probabilitateak kontuan hartu dira. Bigarren sekzioan datuak jasotzeko, prozesatzeko eta aztertzeko metodologia deskribatzen da. Hirugarren sekzioan datuen azterketa aurkezten da. Azkenik, laugarren sekzioan, lortu diren emaitzak erakusten dira; nabarmenena da generoaren araberako aldea estatistikoki esanguratsua izatea.
Ohar batzuk fonologiaren magiaz
Authors: Irurtzun Aritz
Published: January 2025

Magia edota naturaz gaindiko helburuak dituzten erritualetan usu hizketa-ekintzak erabiltzen dira dena delako helburua lortzeko. Artikulu honetan euskal usadioan ekintza magikoetarako erabili izan (omen) diren hitz eta formulei lehen begiratu bat ematen diet haietan markatutasun fonologikoa identifikatuz. Hau eguneroko hizkuntzatikako aldentze baten moduan aztertzen dut, emikoki hizkera “ez naturalaren” erabilera naturaz gaindiko botereekin lotzen delakoan.
1720ko Imitazionearen iturriak: lehen hurbilketa
Authors: Urgell Blanca
Published: January 2025

1720an argitaratu zen, Baionan, Jesus-Christoren Imitacionea. M. Chourio Donibaneco Erretorac escararat itçulia. 303 urte geroago aztertu gabe dirau, eta kritikoki argitaratu gabe, lapurtera klasikoaren emaitza eder honek.
Sor litzakeen galderen artean batek azterrarazi digu: Mixel Xurioren arrebak ez ote zuen Imitazionearen laugarren liburua itzuli, tradizioak dioen bezala. Halere, ezin erantzun Xuriok edo Xuriotarrek Imitazionea itzultzeko erabili zuten iturria zein den jakin gabe. Hauxe da, bada, lan honen xedea: garai eta toki hartan eskura leudekeen jatorrizko testuaren edizio edota itzulpenen berri eskuratu eta 1720ko itzulpena horietatik zeinekin egin zen argitzea.
Azterketa hau lagin labur bitan egindakoa da, baina ondorioak ziurtzat eman daitezke: latin jatorrizkoaren garaitsuko edizio frantsesen bat eta Aranbillaga apaizak egin 1684ko euskarazko itzulpena, biak ere biak aurrean izanik itzuli zen 1720ko Imitazionea. Ostera, ezin izan dugu erabat baztertu Lemaistre-ren frantses itzulpena ere tartean izatea. Konparaketak bide eman du, halaber, Xurioren (edo Xuriotarren) itzulpen-teknika zenbait agerian jartzeko. Bidenabar, Lemaistreren frantsesezkoa Aranbillagarenaren iturri zuzena dela ere frogatu dugu.
Real and Presumed Categories: A Formal Approach
Authors: Uriagereka Juan
Published: January 2025

Categorization is fundamental to any scientific pursuit, posing the question of what categories themselves amount to. Are categories absolute or mere linguistic constructs? If the latter, are they to be trusted? Otherwise, what can one use to ground categories? The present piece reminds us that one can go about this substantively or formally. Substantive, for beings with a neuro-physiological nature, boils down to how we happen to be “wired” or how our brain “works”, whatever that means. Formal ought to be grounded on some abstract system, of the sort that logic and arithmetic represent — given “the unreasonable effectiveness of mathematics”. In this context, I consider whether primitive linguistic (distinctive) features are substantive or formal. In the end, I suggest that this depends on the nature of the feature, and that in some fundamental sense there is ample space for foundational formal features, which has a variety of technical and philosophical consequences worth pursuing.
Training ESL students to reproduce beat gestures in discourse leads to L2 pronunciation improvements
Authors: Prieto Pilar , Kushch Olga , Borràs-Comes Joan , Gluhareva Daria , Pérez-Vidal Carmen
Published: January 2025

The main goal of the present study is to assess whether training foreign language students to reproduce natural beat gestures in discourse can trigger pronunciation gains. A total of 18 young adult Catalan learners of English with an intermediate proficiency level participated in a 15-minute discourse-based pronunciation training session. Participants were randomly assigned to two groups. While one group was asked to simply repeat the instructor’s multimodal responses to discourse prompts by focusing on speech, the other group was asked to repeat the utterances together with the natural beat gestures that the instructor was using. Before and after training, participants were recorded producing a discourse completion task and their speech was rated for accentedness. Results showed that participants who accompanied their verbal repetition with beat gestures during training significantly reduced their accentedness scores more than those who were asked to only repeat the utterances without reproducing the beat gestures. These results support recent findings that show the value of embodied prosodic training for pronunciation instruction.
La condición jurídica de la mujer en el Derecho histórico privado de Vasconia: estudio de las fuentes y propuesta de líneas de investigación
Authors: Alkorta Idiakez Itziar
Published: January 2025

Este artículo aborda la condición jurídica de las mujeres en el derecho histórico privado de Vasconia, explorando la relación entre las normas legales y las dinámicas sociales desde la Alta Edad Media hasta el siglo xix. Mediante el análisis de fuentes jurídicas, historiográficas y bibliográficas, se evalúa la representación jurídica femenina en ámbitos como el régimen matrimonial, la sucesión y la propiedad. Se identifican características distintivas del derecho vasco, como el igualitarismo de género en determinados contextos. Asimismo, el trabajo reflexiona sobre las contribuciones y limitaciones de la historiografía existente, proponiendo nuevas líneas de investigación que permitan superar las lagunas actuales y enriquecer la comprensión de las instituciones legales vascas en clave de género.
MARTÍNEZ BORRALLO, Antonio, Comerciantes vascos y navarros en Madrid. Una élite mercantil ilustrada al servicio de la Monarquía española (1700- 1830), Bilbao: Universidad del País Vasco / Euskal Herriko Unibertsitatea, Argitalpen Zerbitzua = Servicio Edit
Authors: Presedo Garazo Antonio
Published: January 2025

MARTÍNEZ BORRALLO, Antonio, Comerciantes vascos y navarros en Madrid. Una élite mercantil ilustrada al servicio de la Monarquía española (1700-1830), Bilbao: Universidad del País Vasco / Euskal Herriko Unibertsitatea, Argitalpen Zerbitzua = Servicio Editorial, 2022, 464 pp. ISBN: 978-84-1319-396-0
Explorando las huellas escritas en el pasado. Análisis de los útiles hallados en el poblado rural de Barajas, Madrid (ss. VII-VIII)
Authors: Berrica Silvia , Galindo-Pellicena María Ángeles , Barbosa Polanco Juan Felipe , Casado Gómez Ana Isabel
Published: January 2025

El estudio de los útiles de escritura se ha centrado principalmente en el periodo romano, gracias a importantes hallazgos en entornos urbanos, como Augusta Emerita (Mérida, España), y en entornos rurales, por ejemplo Vindolanda (Reino Unido). Sin embargo, para el periodo altomedieval, esta área de investigación continúa siendo una asignatura pendiente debido a la escasez de hallazgos tanto en áreas urbanas como rurales. Las fuentes escritas disponibles para un estudio historiográfico de estos instrumentos son limitadas, y la arqueología no siempre puede proporcionar una tipología específica de estos utensilios, principalmente debido a la naturaleza perecedera de los materiales con los que se elaboraban, como el hueso o la madera. A través del análisis de los materiales encontrados en el poblado de Barajas (yacimiento El Encadenado, Madrid), ha sido posible identificar e investigar diversas herramientas de escritura, tales como un cálamo, un estilete y un tintero, todas datadas en la época altomedieval. Específicamente, estos materiales se sitúan en un periodo de transición entre la era visigoda y la era emiral (siglos VII-VIII). Este trabajo se ha llevado a cabo desde un enfoque multidisciplinar que incluye la presentación del asentamiento arqueológico y la descripción del contexto estratigráfico, el análisis arqueozoológico para determinar la elaboración de los materiales en hueso, la aplicación de la espectroscopía Raman para intentar identificar restos de tinta en el cálamo y, por último, la utilización de la Arqueología experimental con el objetivo de replicar estas herramientas teniendo en cuenta su función en la escritura. En este escrito presentamos por primera vez un análisis detallado de útiles documentados en un poblado de la Meseta Central, al mismo tiempo que reflexionamos sobre la sociedad y la economía rural en la que se encontró.
Espacio doméstico y cotidianidad en la Gallaecia de los siglos IV-V: los asentamientos de O Castelo de Valencia do Sil (Vilamartín de Valdeorras) y Santomé (Ourense)
Authors: Rodríguez-González Celtia
Published: January 2025

El trabajo que se presenta es fruto de la investigación de dos yacimientos gallegos denominados O Castelo de Valencia do Sil (Vilamartín de Valdeorras, Ourense) y Santomé (Ourense). Se trata de poblados encuadrados bajo el concepto de asentamientos en altura, con una cronología asociada a los siglos IV-V d. C., un periodo considerado de abundantes cambios que tienen que ver con el fin del Imperio Romano y el inicio de la alta Edad Media.
Dentro de este panorama, las investigaciones se han centrado en analizar el carácter político de la época vinculado, sobre todo, a las invasiones y la caída del Imperio Romano, obviando la importancia del análisis de la arquitectura doméstica, de lo cotidiano y, en consecuencia, de las personas que vivieron en estos contextos. Las recientes investigaciones y el desarrollo de la arqueología comercial en el noroeste han permitido evidenciar una serie de cambios en el poblamiento y en los asentamientos. Se trata de transformaciones que también influyen de manera directa en las formas de vivir y relacionarse las personas del pasado. En este artículo se expone un primer acercamiento a la arqueología de los espacios domésticos de los siglos IV-V d. C. en el noroeste de la península ibérica a partir del análisis del ámbito doméstico y sus actividades en dos asentamientos clave.
La presencia de cognomina de figuli en grafitos ante cocturam inscritos en ánforas del tipo Dressel 2 producidas en el ager Tarraconensis
Authors: Colom Mendoza Enric
Published: January 2025

Las ánforas del tipo Dressel 2 producidas en diferentes figlinae ubicadas en el territorium de Tarraco presentan características morfológicas únicas, que las hacen fácilmente distinguibles de visu de otras producciones de este mismo tipo anfórico en Hispania. Igualmente, su sistema de sellado también es particular, ya que no presentan sellos epigráficos en posición in pede, a diferencia del resto de producciones más septentrionales. En cambio, nos hemos percatado de un hecho que ha pasado desapercibido hasta día de hoy: la presencia de grafitos ante cocturam sobre pivote, inscritos cuando el ánfora se encontraba en el área de secado, en posición invertida, que están formados por tres letras y cuyo único desarrollo posible son los cognomina de los figuli que elaboraron dichas ánforas. Basamos nuestras afirmaciones en lo sencillo de estas inscripciones, ya que aparecen estos nombres personales inscritos sobre sello epigráfico, que deben representar a los capataces de las cuadrillas de figuli, o a los subordinados encargados de dirigir la figlina, siendo más plausible la primera opción. Este trabajo, por tanto, quiere poner el foco de atención en esta particularidad de las producciones anfóricas del ager Tarraconensis, así como dar a conocer los nombres personales de estos artesanos, que pertenecerían a uno de los estratos sociales más humildes dentro del sistema productivo vitivinícola y su circuito económico de exportación.
Antropomorfos “orantes” en la pintura rupestre esquemática de la provincia de Granada
Authors: Gámiz Caro Jesús , Fernández Ruiz Marcos , Martínez Fernández Gabriel , Martínez García Julián , Spanedda Liliana
Published: January 2025

El presente trabajo estudia los antropomorfos contextualizados en la denominada pintura rupestre esquemática de la provincia de Granada, tradicionalmente conocidos como antropomorfos en Y, doble Y, X y que aquí se engloban bajo el término «orantes». A través de un análisis métrico y estadístico, se pretende obtener una mejor definición tipológica, determinar su distribución espacial y descubrir las relaciones o diferencias en los distintos núcleos definidos en la geografía granadina. El análisis muestra la similitud de tradiciones en la representación de estas tipologías de antropomorfos a lo largo y ancho de todo el territorio provincial, a lo que se suma una amplia distribución en el área meridional de la península ibérica. Por otra parte, se intenta establecer una cronología relativa utilizando paralelos cerámicos que, para las tipologías de los motivos analizados, nos situaría en un ámbito cronológico del Neolítico Antiguo.
The Potential of Online Tasks to Facilitate Autonomous Language Learning with the Use of Online Dictionaries in a Higher Education ESP Classroom
Authors: Girón-García Carolina
Published: January 2025

The use of Information and Communication Technologies (ICTs) and previous studies in lexicography have shown the frustration that many students experience with the amount of information to which they are exposed to solve terminological doubts in the field of English for Specific Purposes (ESP). Yet, ICTs can prepare the ground for learning inside and outside the classroom. The incorporation of technological tools together with the use of integrated resources in Task-Based Language Teaching (TBLT) learning tasks provide multiple benefits in the field of ESP, as well as greater motivation and autonomy. This study aims at shedding new light on the ability of Higher Education (HE) students to (a) learn content and vocabulary with the use of online dictionaries and other online resources in a Legal English course; (b) foster motivation to perform an online task (OT); (c) develop autonomy; and (d) build new knowledge. To achieve this aim, the present study used a mixed-methods approach (i.e., qualitative and quantitative data) and was developed in two stages: (1) Creation and design of the online task (i.e., Lesson integrated into a Moodle platform); design of three questionnaires administered before and after the experiment; and implementation of the OT with university students (N=171) enrolled in a Legal English course; and (2) collection of data and analysis. The results acknowledged the success rates in terms of achievement (i.e., experimental group). The conclusions indicated that this OT had been valuable to students to learn specialised vocabulary and content, as well as to know how to use an online dictionary effectively. The OT design in this research adds value to previous studies’ existing weaknesses in dictionary training. As a result, this OT provides learners with training in the use of online dictionaries, which improves their autonomous language learning.
Improving female fertility preservation through assisted reproductive technologies
Authors: Vesztergom Dóra
Published: January 2025

A fertilitásprezervációs eljárásokon átesett páciensek asszisztált reprodukciós kezelésének eredményességéről kevés információ áll rendelkezésre a szakirodalomban. Ugyanakkor az onkológiai konzultáción a pácienssel ismertetni szükséges a daganatellenes kezelés termékenységet érintő káros következményeit, a jövőbeli kívánt várandóssági esélyeket, hogy az érintett olyan kezelési stratégiát válasszon, amelynek eredményességével tisztában van, és megfelel az elvárásainak. A fentiek okán alapvető fontosságú, hogy vizsgáljuk a fertilitásprezervációs eljárásokat követő asszisztált reprodukciós kezelések eredményességét. Kutatásunk három fő célkitűzése: 1. Egy magyarországi onkofertilitás-hálózat létrehozásához szükséges teendők felmérése: - Tanulmányunk célja, hogy felmérjük a magyarországi daganatos nőbetegekkel foglalkozó szakemberek fertilitásprezervációval kapcsolatos informáltságát, külön hangsúlyt fektetve azon tényezők megismerésére, amelyek akadályozhatják a fiatal daganatos betegek termékenységmegőrzési programhoz való hozzáférését. 2. Az IVF kezelés eredményességének vizsgálata korai stádiumú méhnyakrák műtéti ellátását követően: - A nem radikális méhnyak eltávolítás, illetve a radikális műtéti eljárást követő IVF kezelések eredményességének vizsgálata és összehasonlítása. 3. Új, innovatív eljárások vizsgálata a termékenység megőrzésében: - Az IVM (in vitro maturatio), mint innovatív termékenységmegőrző eljárás indikációinak vizsgálata és fertilitásprezervációs programba történő integrációja