bluuebunny/crossref_metadata_2025 huggingface dataset:
An Analysis of Primary Care Physician Accessibility and Medical Resource Distribution in Eastern Quebec: Utilizing an Enhanced Two-Step Floating Catchment Area (E2SFCA) Methodology
Authors: Simoneau Christian
Published: August 2023

This study evaluates the accessibility of primary care physicians (PCPs) in Eastern Quebec using an enhanced two-step floating catchment area (E2SFCA) methodology. The E2SFCA methodology considers both the population supply of PCPs and the travel time between PCPs and dissemination areas, and was found to be effective in identifying possibly underserved areas. The availability of primary care services is contingent upon the presence of adequate road infrastructure, and populations residing in areas with limited access to main road networks may experience compromised access to primary care. The study concludes that the E2SFCA methodology can facilitate the identification of areas experiencing a shortage of PCPs, and this information can be used to inform the development of regional medical workforce programs and support the establishment of rural residency initiatives.
ANALYSIS OF NATURALIST INTELLIGENCE OF STUDENTS IN CLASS XI IPS OF SANTO LEO HIGH SCHOOL, WEST JAKARTA
Authors: Rimba Fellix , Nandi Nandi , Astari Annisa Joviani
Published: August 2023

This study aims to determine the level of naturalist intelligence of students in class XI of Santo Leo High School, West Jakarta. This research uses descriptive-qualitative method. The population and sample in this study used Simple Random Sampling with students in class XI IPS SMA Santo Leo West Jakarta as many as 32 people. the instrument used in this study is a questionnaire related to naturalist intelligence. The results showed that the naturalist intelligence of students in class XI IPS SMA Santo Leo West Jakarta was classified as a high category with a score of 3.89. As explained in detail the achievement of each indicator is Distinguishing members of a species gets a score of 4.10 with a high category, Recognizing the existence of species with a penchant for being in the open nature of the medium category (3.54), Mapping the relationship between several species, either formally or informally with a score of 4.00 (High category) and Researching natural symptoms with a score of 3.90 which is classified as high.
UTILIZATION OF LANDSAT 7 AND 8 IMAGES FOR MAPPING OF CHANGES IN THE NORTH COAST MANGROVE AREA, AESESA DISTRICT
Authors: Wea Maria Matilda , Rahmawati Arfita , Hasan Muhammad Husain
Published: August 2023

In 2019 there was damage to the mangrove forest which was converted into fish ponds by cutting down 200 hectares of mangrove land in Aeramo Village, which is the northern coastal area of Aesesa District, Nagekeo Regency. This study aims to map changes in mangrove areas and determine mangrove density values.This study uses the NDVI (Normalized Difference Vegetation Index) analysis technique to determine the density of mangrove vegetation in 2011, 2016 and 2021 using Landsat 7 and Landsat 8 imagery and uses an overlay analysis technique from the results of classifying mangrove density classes to determine changes in the area of mangrove areas. The results of the study show that the mangrove area on the north coast of Aesesa District shows density values that vary with The range of vegetation density index in Landsat 7 imagery in 2011 is from -0.573770464 to 0.54666682, in 2016 it has a vegetation density index range from -0.291984737 to 0.609456897 and in 2021 it has a vegetation density index range from -0.067266561 to 0.579148531 which is divided into 5 density classes namely; very rare, rare, moderate, rare and very tight. Based on the classification results, the results of changes in the mangrove area decreased to the medium class with forest area from 102.35 hectares to 66.86 hectares from 2011 to 2016 and experienced the largest increase in the very dense class in 2011-2016 where the forest area was in the very dense class. meeting from 128.86 hectares to 210.65 hectares.
CROSS-BORDER FLOOD MANAGEMENT IN BENGAWAN SOLO HULU WATERSHED
Authors: Sholeh Sofyan , Yusup Yasin
Published: August 2023

Cross-border floods are not only cross-country and cross-province floods but also include cross-district/city floods. The flood that occurred in Sukoharjo Regency was a cross-border flood (cross-border flood) covering four upstream districts, namely Boyolali, Klaten, Wonogiri and Karangnanyar Regencies. The management needed concerning cross-border flooding is the handling of integrated cross-border synergies that enter the Watershed (DAS) with countermeasures, not only structural but non-structural, and involving all stakeholders. This study uses a combination of spatial science and critical human geography paradigms so that the appropriate research design is a mixed method, namely research with both quantitative and qualitative techniques. The critical human geography paradigm is also used here in conjunction with the political ecology approach in tracing the increased risk of flood disasters associated with an expanded urbanization process, an approach derived from production space theory. The results of this study show that the integration of disaster management between regions is very important, both upstream and downstream. Human activities in the upstream region greatly affect the downstream region
CHARACTERISTICS AND DISTRIBUTION OF UNMET NEED SOUTH SUMATRA BASED ON GEOSPATIAL
Authors: Damayati Nina , Murjainah Murjainah , Oktavia Maharani , Heldayani Eni , Taufik Mirna
Published: August 2023

Unmet need in South Sumatra in 2019 was 11.13% and in 2021 the number of unmet need was 15.23%, this figure had increased quite significantly and also still did not fulfill the work agreement of the BKKBN representative for South Sumatra Province which targeted 8.07% That is, this achievement, when referring to BKKBN's target of reducing unmet need for family planning, can be said to have not decreased significantly. The purpose of this study is to determine the characteristics and distribution of Unmet Need in South Sumatra on a geospatial basis. The method in this study uses a quantitative descriptive approach by utilizing secondary data from the 2017 IDHS as well as data on Indonesian families for 2021 conducted by the BKKBN. The treatment of unmet need data is to determine the characteristics and distribution of unmet need data in South Sumatra Province by processing data, analyzing data, and producing geographically referenced outputs. Characteristics of unmet need occur mostly in PUS aged over 35 years with more than two children, the highest education level is at the elementary school level of 11.8% and living in urban areas. The results obtained in the field are that there are many unmet needs due to the impact of the Covid-19 pandemic where many PUS are afraid to access contraceptives at health facilities, complete large-scale social activities, and terminate employment.
ADAPTIVE CAPACITY AND RESILIENCE TO THE EARTHQUAKE AMONG STUDENTS IN KLATEN REGENCY
Authors: WIbowo Yunus Aris , Safriani Eka Wulan , Ronggowulan Lintang , Dewi Ratih Puspita , Hafida Siti Hadiyati Nur , Widiyatmoko Wahyu , Wardhani Puspita Indra , Septiningrum Usmaningtyas Ayu Dwi , Putri Sindi Ashyari , Aris Ibnu Abdullah , Wijayanto Saifulloh Rizqi
Published: August 2023

One of the risk components that are most vulnerable to earthquake disasters is children. Klaten Regency is one of the areas frequently shaken by earthquakes. Therefore, this study aims to measure students' adaptive capacity and resilience to earthquakes in the Klaten Regency. Respondents in this study were students of SMP M 8 Wedi, MTs M 10 Wedi, and SMP M 21gantiwarno, Klaten Regency. The adaptive capacity of students is measured based on institutional memory, innovative learning, and connectedness. In contrast, students' resilience level is measured based on emotion regulation, control over problems, optimism, empathy, self-efficacy, ability to analyze issues, and achievement. Data were collected using a questionnaire and processed using descriptive statistics. The level of adaptive capacity and resilience of the student community to natural disasters has different characteristics due to the influence of several factors such as the location of the school in a disaster-prone area, the integration of disaster material into learning, experience in disaster emergency response conditions, school policies on disaster mitigation and family or community factors environment. The best level of adaptive capacity is found in SMP Muhammadiyah 8 Wedi with 62.90%, and MTs Muhammadiyah 10 Wedi has a poor level of adaptive capacity with 44.32%. Moreover, based on gender characteristics, the level of adaptive capacity of male students is better than female students, with the lowest percentage being female at MTs Muhammadiyah 10 Wedi. The highest level of student resilience is found at MTs Muhammadiyah 10 Wedi at 61.36%, while SMP Muhammadiyah 21 Gantiwarno is classified as poor at 33.33%. Based on gender characteristics, the highest level of resilience is female at MTs Muhammadiyah 10 Wedi, with 91.67%.
Pandangan Tokoh Arjuna Terhadap Stereotip Perempuan dalam Novel Populer Perempuan Bernama Arjuna Karya Remy Sylado
Authors: Karima Nadia
Published: August 2023

This study aims to describe the image and stereotype of Indonesian women and the resistance ofthe character Arjuna in the popular novel Perempuan Bernama Arjuna against the image andstereotype that is widely developed. Arjuna is an Indonesian woman, father of a Chinese descentand mother who has thick Javanese blood. Arjuna, who is 25 years old, is a philosophy student ata university in the Netherlands. The method used in this research is descriptive analytic methodusing literature review technique. The data source used is the novel Perempuan Bernama Arjunaby Remy Sylado. The results of this study indicate that in the novel Perempuan Bernama Arjuna,there are 13 stereotypes of women. Of the 13 stereotypes of women that emerged, there were 10stereotypes that Arjuna refuted and considered not really representative of what womenexperienced, including himself, for example regarding women whose beauty is only judged fromtheir physical appearance. For him, the beauty of women is not only seen from the physical,more than that, women can also be judged from their intellectual level. There will be no use if awoman is physically beautiful, but does not have a qualified level of intelligence. In addition,there are 3 stereotypes of women whose existence Arjuna agrees with is also attached to him, forexample about women who are not used to speaking frankly as is in their hearts and heads.Arjuna who was educated by a mother who came from the Javanese tribe also adheres to onething taught by his mother, namely that a woman must be good at watching hermouth.
Gender Role dalam Film Keluarga Cemara
Authors: Tounbama Siti Syamsiah Renny
Published: August 2023

Abstrak

Isu gender merupakan pembahasan yang tidak ada habisnya. Pembahasan mengenai keadilan gender memunculkan narasi kesetaraan gender. Berbeda halnya dengan kesetaraan gender, terdapat narasi keserasian gender yang mengangkat perbedaan antara perempuan dan laki-laki sebagai suatu kerangka kerja yang saling melengkapi. Keserasian gender berkaitan erat dengan peran perempuan dan laki-laki sesuai porsinya. Untuk itu dalam artikel ini akan dijabarkan mengenai keserasian gender melalui peran gender perempuan dan laki-laki dalam film Keluarga Cemara. Penelitian ini merupakan penelitian kualitatif deskriptif. Objek kajiannya yaitu peran gender dalam film Keluarga Cemara. Adapun hasil penelitian menunjukkan bahwa terdapat peran gender laki-laki meliputi kategori standard bearers yaitu peran be the best you can dan good samaritan, kategori workers yaitu peran work ethic, kategori lovers yakni peran breadwinner dan nurturer, serta kategori bosses yaitu peran control. Sementara peran gender perempuan yaitu peran reproduksi dan peran produksi. Perbedaan peran antara perempuan dan laki-laki ini saling berkaitan dan melengkapi satu sama lain. Dalam film Keluarga Cemara ini tokoh Abah dan Emak menunjukkan adanya keserasian gender dalam sebuah keluarga.
Analisis Kritis Citra Perlawanan Wanita Secara Feminis dalam Novel Maryam Karya Okky Madassari
Authors: Zulfahreza
Published: August 2023

This writing aims to answer the questions in the previous paragraph, the method used by the researcher is a feminist discourse analysis method In this writing, the theory that will be used is the theory of feminism in relation to this novel telling the story of a woman who voiced her rights. In this study the most important problem is how women are displayed and speak in voicing their rights and how the struggle is displayed through the selection of words, sentences and forms of stories to the public. The analysis technique used in this study was the analysis of the Wacana Sara Mills. This method is used in research that focuses on the discourse of women. The point of attentive this method is about how women are displayed in the text. The results of this study concluded that the resistance movement carried out by women could be done through the literary road. By displaying women as a tough main character as a subject who sued the culture of patriarchy who had already been well-established in the community as objects and readers were led to consciously be aware of the mistake that often cornered women.
Terjemahan Takarir Dialog Berbahasa Arab dalam Film Ketika Cinta Bertasbih 1
Authors: Marzuq Ahmad , Sarip Mohamad
Published: August 2023

The entertainment industry, including foreign language films, can be an interesting object of study in translation studies. In foreign language films there are translations in various languages, according to the object of the audience. The film When Cinta Bertasbiqh I (KCB I) is one of the films in which there are dialogues in foreign languages, in this case Arabic. The subtitles of this film (subtitles) can be researched by being oriented towards the source language and the target language. This can be seen from some of the dialogues in the KCB I film which features various Arabic fusha and Egyptian 'amiyah. Therefore, this study aims to describe and classify the variety of sentences in the dialogues contained in the KCB I film along with their translations. From the results of the analysis it was found that the fusha variety is more often used in formal conditions, while the Egyptian 'amiyah variety is widely used in daily dialogue. The translations presented in the subtitles of the KCB I film tend to prioritize equivalence of meaning and are more oriented to the target language, this allegedly aims to provide comfort to the audience.
Retorika Komunikasi Aa Gym dalam Kajian Al-Hikam “Jangan Sia-Siakan Waktu”
Authors: Ahmad Yousef Bani
Published: August 2023

The purpose of this study is to find out what the rhetorical element in Aa Gym's oral discourse looks like when delivering its da'wah message to the congregation regarding the study of Al-Hikam with the topic “don't waste time" and then how to use the rhetorical function of Aa Gym in conveying its da'wah message to the congregation. This research uses a qualitative-descriptive approach with content analysis. The data source is taken from a youtube video, the Media Da'wah Hikmah TV channel. The findings of the study conducted are that speakers have great persuasion in every sentence that is simple and easy to understand, conciliatory intonation and calm body language. In the content of the conversation, everything is assembled and conceptualized with a good plot. The opening, body and closing sentences are able to arouse the feelings of those who hear them. Judging from the audience, they are very happy and comfortable when listening to Aa Gym's lectures that are in accordance with the realities of life. The rhetorical function used by Aa Gym when delivering its da'wah is corrective, instructive and suggestive rhetorical functions. The expected implication in this research is knowledge of da'wah strategies that can be applied with a rhetorical approach to be able to convey sentences in oral discourse that are able to give influence and have a good impact on listeners.
Refleksi Feminisme dalam Novel The Great Gatsby Karya F. Scott Fitzgerald
Authors: Ridwan Ahmad
Published: August 2023

The purpose of this study was to describe the reflection of feminism and the factors causing the rebellion emergence on female characters in this novel The Great Gatsby written by Francis Scott Key Fitzgerald. The research method used was descriptive method with the qualitative research form. The approach used was a feminist literary criticism approach. The technique used was documentary study. The data source was a novel The Great Gatsby (1925) using his background in New York. The problem of this research was how the feminism reflection was emphasized on the figure of women like Daisy, Jordan and Myrtle, who were female figures in the novel The Great Gatsby, especially their behavior towards men. The results showed another side of women's lives, a phenomenon that rarely occured when a woman's determination and determination tried to get out of a life that was not taking its side. The position of women implied the perception of society that the position of women, especially with regard to work was still underestimated
Brand Image as a Mediating Variable of the Influence of Perceived Ease of Use and Price on Customer Satisfaction
Authors: Nur Faiza  , Nursani
Published: August 2023

Customer satisfaction is important for the sustainability of businesses, both online and offline. The purpose of this research is to examine the role of brand image in mediating the relationship between perceived ease of use and price on customer satisfaction. Data was collected by distributing questionnaires to 160 respondents in East Java who had made online purchases using TikTok Shop in the last 3 months. Then, the hypotheses in this study were tested using Partial Least Squares (PLS). The research findings reveal that: (1) Perceived ease of use has a positive and significant effect on customer satisfaction; (2) Perceived ease of use has a positive and significant effect on brand image; (3) Price has a positive and significant effect on brand image; (4) Price has a positive and significant effect on customer satisfaction; (5) Brand image has a positive and significant effect on customer satisfaction; (6) Brand image is able to mediate the influence of perceived ease of use on customer satisfaction; (7) Brand image is able to mediate the influence of price on customer satisfaction.
The European Union's Interest in Implementing The Renewable Energy Directive II (RED II) Policy on The Issue of Discrimination Against Indonesian Palm Oil
Authors: Salsabilla Annisa , Munziin Khairul , Ningrum Indah Karya , Rahayu Dini Septyana
Published: August 2023

The discrimination of Indonesian palm oil imposed by the European Union through the Renewable Energy Directive II (RED II) policy provides mixed and overlapping speculation. This is evident by the E.U.'s unpublished interest in the issue of discrimination against Indonesian palm oil. The purpose of this study is to find out the hidden interests or objectives of the European Union after imposing trade barriers on Indonesian palm oil exports, which will be reviewed through the theory of neo-mercantilism and also the concept of national interest. This research uses qualitative methods in collecting data related to problems using a descriptive approach to ensure a consistent understanding of the ideas considered. Our analysis shows unprecedented public interest in the European Union regarding discrimination against Indonesian palm oil. This is an effort to protect the European Union from their domestic vegetable oils being less competitive than vegetable oils from Indonesian palm oil. The European Union imposed trade barriers to prevent Indonesian palm oil from quickly entering the European market.
Keywords: palm oil discrimination, European Union, RED II
The Role and Perspective of Islamic Organizations on The LGBT Movement in Indonesia
Authors: Wulandari Regita Safitri , Anjani Erina Wahyu , Rieftiani Retnadhieas Azzah
Published: August 2023

LGBT has become a global phenomenon proved by the massive movement carried out, proves that the presence of LGBT has been supported and accepted by many countries. On the other hand, LGBT also reaps a lot of resistance in several countries, one of which is in Indonesia. This is because Indonesia is a country with a majority Muslim population, which in Islam itself strongly rejects the LGBT movement. This study aims to discuss the roles and perspectives of several Islamic mass organizations in Indonesia in dealing with the LGBT phenomenon, namely the MUI, NU, and Muhammadiyah movements. This article uses the concept of the role of Non-Governmental Organizations (NGOs) with data collection carried out via the internet by searching and collecting bold documents from the organizations under study. This research found that the role of the three mass organizations is still quite minimal in terms of most of their activities which are still limited to short statements and protests in dealing with the problem of LGBT which has become widespread in Indonesia. This research recommends that these three Islamic organizations should act comprehensively as NGOs to contain the influence of LGBT in Indonesia.

Keywords: Indonesia, Islamic Organizations, LGBT, Threats.
Dandelion Has Successfully Adapted to Grow in Suburban Environments
Authors: Abraham Thomas , Abraham Teresa , Thomas Sunil
Published: August 2023

Dandelion (Taraxacum officinale G.H. Weber ex Wiggers) is a perennial herbaceous plant, generally considered as a weed, often seen blooming in the temperate areas during early spring. The wind dispersed seeds of dandelion has been known to travel long distances. Our study demonstrates that the flower stalk elongate during seed head formation and grow vertically at 900, which may aid in seed dispersal to new locations. It is not fully understood whether suburban environment influence the physiology of dandelions. Dandelions growing in nature reserves or wastelands are significantly taller compared to those growing in lawns in the suburbs. In the lawns of the suburbs, the flower stalk of dandelion is shorter, with an angle of 300 or lower, and grows parallel to the lawn grass so that they can escape lawn mowing. In addition, the dandelion plants in the suburban lawns have shorter leaves and smaller flowers. Thus, the dandelion has adapted vegetative features for survival in the suburbs.
The Israeli Anesthesiology Workforce Crisis: A Reassessment Survey
Authors: Wimpfheimer Ariel , Ginosar Yehuda , Fein Shai , Goldberger Esty , Weissman Charles
Published: August 2023

Background: Anesthesiologists provide crucial anesthesiology services in the operating room and non-operating room locations. Combined with an aging and growing Israeli population, there is an increasing demand for anesthesiology services. A previous study performed in 2005 showed that most anesthesiologists are immigrant physicians with few Israeli medical school graduates. Since then, the number of physicians immigrating has decreased and many have retired, resulting in an anesthesiologist shortage, limiting surgeries and other procedures in many hospitals.
The present study examined the current state and composition of the Israeli anesthesiology workforce and compared it to the 2005 workforce.
Methods: A survey among anesthesiology department chairs in all 34 Israeli acute care hospitals provided information about each of their department's anesthesiologists.
Results: There are 1313 anesthesiologists in the 34 hospitals, resulting in a ratio of 14.2 anesthesiologists per 100,000 population. 22.6% of anesthesiologists will reach retirement age over the next ten years. The proportion of female anesthesiologists was 28.7%. While Israeli medical school graduates increased to 18.1% from 12.2% in 2005, non-Israeli citizens and non-permanent residents comprised 8.5% of the workforce.
Conclusions: Despite growth in the ratio of anesthesiologists per population, a workforce shortage is expected to worsen over the next ten years due to retirements, shortened call hours, and the Yatziv reform. The current workforce has compensated for the existing shortage of anesthesiologists by enlisting non-Israeli trainees from overseas. Yet, it is crucial to maintain and enlarge the indigenous Israeli workforce to forestall a worsening shortage.
Addressing the disproportionate breast cancer burden in LMICs: Outcomes from an interventional study evaluating preventing teachings in high schools
Authors: Ifediora Christian , Veerman Lennert , Obiozor Williams , Ifediora Obinna
Published: August 2023

Background:
The WHO opines that the current disproportionate breast cancer burden and poor outcomes in LMICs fuel global inequalities, which are further compounded by a lack of ‘awareness’ in these regions. Targeting teenage high schoolers in these countries has been mooted as a viable solution. This paper evaluates a Harvard-endorsed initiative to achieve this, in what was a global first.
Method:
A 12-month, quasi-experimental (pre-and-post-tests) study of three randomly-selected schools in Southeast Nigeria. Exposure to anti-breast cancer teachings with integrated engagement-enhancing measures was the intervention.
Results:
Compared to 81.3% at baseline, breast cancer awareness was unchanged at one-month post-intervention (OR-1.10; CI 0.96-1.26), but significantly rose to 92.1% at the 12-month mark (OR-0.37; CI 0.26-0.52). Knowledge of breast self-examination (BSE), assessed as a marker of behavioural change, increased steadily. Levels at the baseline were 62.0% and 85.0% lower than that at one (OR-0.38; CI 0.34-0.42) and 12 months (OR-0.15; CI 0.12-0.19), respectively.
General, non-specific breast cancer knowledge did not improve over 12 months, but specifics related to early symptoms and risk factors, did. While, over the 12 months, ‘knowledge’ of preventive behaviours was not consistently improved relative to baseline, its actual ‘practice’ increased at both the one (+13.5%) and twelve (+17.3%) month marks, even though its correct timing only improved after 12 months (+6.9%; p=<0.01) and not at one month (+0.8%; p=0.17).
Even though knowledge among females was consistently higher than in males at all phases, prolonged intervention (at 12 months) not only allowed males to match females on a few parameters, but also ensured that knowledge reversal, evident among males at the one-month mark, became eliminated.
Knowledge among under-15-year-old participants matched that of the older ones on eight of eleven parameters.
Conclusion:
Provided anti-breast cancer interventions focus on specific, not general, messages, and inbuilt measures that enhance engagement (like the repetition of teachings and the inclusion of exam/assessment techniques) are in place, targeting high schools appear reasonably impactful on knowledge and preventive practices for all relevant ages and gender. Such outcomes, known to engender better breast cancer outcomes, might hold the keys to finally stemming the inequalities in LMICs.
Impact Of Mir-106b And ATF5 3′UTR Polymorphisms On The Risk Of Hepatocellular Cancer In A Guangxi Population
Authors: Liu Shuyan , Qiu Moqin , Qiu Jialin , Liu Yingchun , Zhou Xianguo , Liu Haizhou , Yu Xiangyuan , Yu Hongping , Jiang Yanji
Published: August 2023

Objectives: Polymorphisms of miRNAs have become a powerful tool for studying disease biology and are used in the prognosis and diagnosis of various diseases, including liver cancer. In this research, we want to evaluate the effect of miR-106b and ATF5 polymorphisms on hepatocellular cancer (HCC).
Methods: Three single nucleotide polymorphisms on miR-106b and ATF5 were selected for genotyping by Agena MassARRAY in 813 HCC patients and 896 healthy controls. After analysis using PLINK software, Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression analysis to assess the risk of HCC.
Results: We evaluated the combined effect of SNP rs2261360, rs1527423 and rs8647 on the risk of HCC and found that the combined 1-3 risk genotypes were significantly associated with the high risk of HCC (OR = 1.52, 95% CI = 1.09‐2.12, P = 0.013) after adjusting for variables such as sex, age, drinking history, smoking history, HBV infection. Further stratification analysis showed that Similar joint effects of these 3 SNPs restricted the risk of HCC in males, non-smoking, non-drinking, and people infected with HBV were more pronounced related to a decreased HCC risk.
Conclusions: This study provides evidence that miR-106b rs2261360 decreased the risk of HCC. The miR-106b rs2261360 wild type, rs1527423 mutant, and ATF5 rs8647 wild type may collectively contribute to the risk of HCC.
Does a Junior Doctor focused ‘Bootcamp’ improve the confidence and preparedness of newly appointed ENT registrars to perform their job roles?
Authors: Rai Amar , Shukla Shivani , Mehtani Nikita , Acharya Vikas , Tolley Neil
Published: August 2023

Background
To assess changes in confidence and preparedness after conducting a 2-day induction bootcamp for novice Ear Nose and Throat (ENT) first year specialty trainee registrars (ST3s) in the United Kingdom (UK). The bootcamp covered common ENT presentations on the ward, and in the elective and emergency settings.
Methods
A total of 32 trainees (ST3 or research fellow) voluntarily registered via an online application form to the Southern ST3 accelerated learning course bootcamp through ENT UK.12 ENT UK is a membership body that supports ENT trainees throughout their careers.13 They completed a two-day bootcamp that was hosted at St Mary’s Hospital, London and 10 skills sessions were delivered by either a senior ENT registrar or an ENT consultant. A pre-session questionnaire was distributed to all participants and a post-session questionnaire was provided that assessed the changes in confidence and preparedness of the participants, if any. The responses were scored by a 10-point Likert scale. Only participants who fully completed the pre and post questionnaire were included, which was 29 in total.
Results
Participants self-reported a significant increase in confidence (p < 0.001) and preparedness (p < 0.001) following the bootcamp course. The greatest improvements in comparison to all other stations were self-preparedness in the rigid bronchoscopy station and self-confidence in the sphenopalatine artery (SPA) ligation station.
Conclusion
The use of a two-day bootcamp improved confidence and preparedness of managing common ENT presentations in the ward, elective and emergency settings for ENT ST3s. It provides a useful adjunct in the acquisition of technical and non-technical skills alongside the traditional surgical apprenticeship. In the future, more work is required to assess the impact of bootcamps on patient outcomes and long-term benefits on trainees’ skill retention and clinical proficiency.
The effectiveness of Nature-Based Therapy for community psychological distress and well-being during COVID-19: a multi-site trial
Authors: Yang Yeji , Kim Hyunjin , Kang Minjung , Baik Hyunjin , Choi Yunseok , Jang Eu-Jean , Chang Eun-Jin , Yun Sukyoung , Park Miok , Park Eunyeong , Yun Hojun , Lee Taek-Joo , Kwon Yeong-Han , Hong Kwang-Pyo , Lee Ai-Ran , Jung Songhie , Ahn Tai-Hyeon , Jin Hye-Young , Choi Kee-Hong
Published: August 2023

During the COVID-19 pandemic, the world population suffered from a range of mental health problems, and there has been a need for new community-based psychosocial interventions. This study aimed to investigate the effectiveness and feasibility of Natural-Based Therapy (NBT) for the community experiencing psychological distress during the pandemic. A multi-site trial comparing NBT and control groups was conducted. In total, 291 participants with mild to severe depression or anxiety were recruited from 11 sites in Korea. A total of 192 participants participated in 30-sessions therapeutic gardening, and 99 remained in the control group. Mental health and well-being were assessed using seven measures of depression, anxiety, daily activity, life satisfaction, mindfulness, stress, and loneliness. The effect sizes (Cohen’s d) were medium to large: depression (0.583), anxiety (0.728), daily activity (1.002), life satisfaction (0.786), mindfulness (0.645), stress (0.903), and loneliness (0.695). Multilevel analysis showed significant interaction effects in the Time × Group for all measures. The results of the Pearson correlation analysis indicated that changes in all variables correlated significantly with each other, with moderate to large effect sizes. Therapeutic alliance at post-test moderated intervention outcomes. We concluded that NBT is a promising psychosocial intervention for treating psychological distress for community dwellers.
The Impact of the COVID-19 Pandemic on Mental Coping and emergency ability of public health emergency in COVID-19 Department Healthcare Workers in ICU nurses of Beijing in China
Authors: Gai Tiantian , He Yin , Yin Ying , Cui Yu , HU Yanzhen , Lu Zhenhui , Li Qiuping
Published: August 2023

Aim: The aim of the study was to evaluate the Current status and influencing factors of emergency ability of ICU nurses in public health emergency during COVID-19 and future public health crises in CHINA
Design: A cross-sectional descriptive study.
Methods: A convenience sample of 486 subjects were collected from seven general public hospitals in Beijing, China, all of which are Grade-A Tertiary Hospitals, From November 8th to15th of 2022.
Results: The Emergency ability of ICU nurses hover at the intermediate level (145.42±23.29). The variables of Work experience, Participated in PHE rescue activities, Participated in PHE education, Cumulative rescue more than 10 times and positive coping were associated with the Emergency Ability of ICU nurses.
Conclusion：Despite the COVID-19 restrictions，the Emergency ability of ICU nurses is acceptable, at a medium level.The ICU nurse of seniority, participated in PHE rescue activities, Participated in PHE education, Cumulative rescue more than 10 times had excellent emergency ability；The importance of psychological coping style was also evident, which means that intervention in psychological is seen as necessary.
Patient or public contribution: All participants made important contributions to the conduct of this study by filling out self-reported questionnaires.
Forest Cover Change Assessment in the Sangu River Basin Using Sentinel-2 Satellite Data
Authors: Rahman M. Mahmudur , Pramanik M. Abu Taleb , Saimun Md. Shamim Reza , Islam Ziaul
Published: August 2023

Forest covers are changing at an alarming rate, in particular to the tropics, emphasizing the need for continuous forest monitoring using satellite technology. Forest cover change in the Sangu River Basin in the Chittagong Hill Tracts (CHT), Bangladesh is typically missing and this study aims to fill the gap by applying a suitable methodology for mapping forest cover change in the area using Sentinel-2 satellite images. Maximum Likelihood, Minimum Distance, Support Vector Machine, and Random Forest classification methods were examined and Minimum Distance Classification Algorithm was chosen for mapping forest cover. Forest cover maps of 2016 and 2020 and forest cover change map of 2016–2020 were prepared. The accuracy of image classification was assessed with 300 random points; overall accuracy of classification was 91.7% and 94.7% for 2016 and 2020 satellite images, respectively. The study revealed that the major Land Use and Land Cover (LULC) classes remained stable over the study period (2016–2020) with a total area of 98.2 thousand ha. Among these classes, forest area is extended over 46.4 thousand ha (37.5%) and shrub classes cover around 45.7 thousand ha (37.0%). The change classes comprise 23.2 thousand ha (20.6%), with the largest conversion class being forest to shrubs or forest to bare land representing deforestation, which is around 17.7 thousand ha (around 14.3%). Shifting cultivation is identified as the major driver of forest cover change in the region. This process has converted many areas of CHT into shrub-dominated areas. The result of the study can assist local forest managers in combating deforestation and conserving the remaining forest in the region.
Based on transcriptome and metabolome analyses, a preliminary study on the causes of changes in paintings during Hibiscus syriacus flowering
Authors: LI Zhezhe , LIU Dan , WANG Dongsheng , SUN Meng , ZHANG Guojun , WU Yu , ZHANG Yidan , Cheng Bei-bei
Published: August 2023

Background
The flower color of H. syriacus 'Qiansiban' undergoes a transition from fuchsia to pink purple and finally to pale purple, thereby enhancing the ornamental value of the cultivars. However, the molecular mechanism underlying flower color change is still unclear in H. syriacus. In this study, the transcriptomic data ofH. syriacus 'Qiansiban' at five developmental stages were analyzed to investigate the impact of flavonoid components on flower color variation. Additionally, five cDNA libraries were constructed from H. syriacus 'Qiansiban' during critical blooming stages, and the transcriptome was sequenced to investigate the molecular mechanisms underlying changes in flower coloration.
Results
High-performance liquid chromatography‒mass spectrometry detected five anthocyanins in H. syriacus 'Qiansiban', with malvaccin-3-O-glucoside being the predominant compound in the flowers of H. syriacus at different stages, followed by petunigenin-3-O-glucoside. The levels of these five anthocyanins exhibit a gradual decline throughout the flowering process. In terms of the composition and profile of flavonoids and flavonols, a total of seven flavonoids were identified: quercetin-3-glucoside, luteolin-7-O-glucoside, Santianol-7-O-glucoside, kaempferol-O-hexosyl-C-hexarbonoside, apigenin-C-diglucoside, luteolin-3,7-diglucoside, and apigenin-7-O-rutinoside. A total of 2702 differentially expressed genes were identified based on the selected reference genome. Based on the enrichment analysis of differentially expressed genes, we identified 9 structural genes (PAL, CHS, FLS, DRF, ANS, CHI, F3H, F3'5'H, and UFGT) and 7 transcription factors (3 MYB, 4 bHLH) associated with flavonoid biosynthesis. The qRT‒PCR results were in good agreement with the high-throughput sequencing data.
Conclusion
This study will establish a fundamental basis for elucidating the mechanisms underlying alterations in the flower pigmentation of H. syriacus.
Synergistic Morphology and Feedback Control for Traversal of Unknown Compliant Obstacles with Aerial Robots
Authors: Aucone Emanuele , Geckeler Christian , Morra Daniele , Pallottino Lucia , Mintchev Stefano
Published: August 2023

Animals can traverse vegetation by direct physical interaction using their entire body to push aside and slide along compliant obstacles. Current drones lack this interaction versatility that stems from synergies between body morphology and feedback control modulated by sensing. Taking inspiration from nature, we show that a task-oriented design allows a drone with a minimalistic controller to traverse obstacles with unknown elastic responses. A discoid sensorized shell allows contact to be established and sensed anywhere along the shell and facilitates the sliding along the obstacle. This simplifies the formalization of the control strategy, which does not require a model of the interaction with the environments, nor high-level switching conditions for alternating between pushing and sliding, thereby reducing the computational burden. Indeed, we exploit an optimization-based controller that only ensures safety constraints on the state of the robot and dampens the oscillations of the environment during the interaction, even if the elastic response is unknown and variable. Experimental evaluation, using a hinged surface with three different stiffness values ranging from 18 to 155.5 Nmm/rad, validates the proposed strategy and the necessity for the synergic task-oriented design and feedback control. By also showcasing the traversal of real branches, this work makes an initial contribution toward drone flight across cluttered vegetation, with relevant applications in environmental monitoring, precision agriculture, and search and rescue.
Structural basis for pathogenic variants of GJB2 and hearing levels of patients with hearing loss
Authors: Namba Kazunori , Mutai Hideki , Matsunaga Tatsuo , Kaneko Hiroki
Published: August 2023

OBJECTIVES The crystal structure of the six protomers of gap junction protein beta 2 (GJB2) enables prediction of the effect(s) of an amino acid substitution, thereby facilitating investigation of molecular pathogenesis of missense variants of GJB2. This study mainly focused on R143W variant that causes hearing loss, and investigated the relationship between amino acid substitution and 3-D structural changes in GJB2.METHODS The R143W and structurally related variants of GJB2 were modeled using the crystal structure of GJB2 as a template. Patients with nonsyndromic hearing loss who appeared to have two GJB2 pathogenic variants, including the R143W variant, were investigated.RESULTS The predicted structure demonstrated that the hydrogen bond between R143 and N206 was important for the stability of the protomer structure. Also, R143W related N206S and N206T variants showed loss of the hydrogen bond.CONCLUSION Investigation of the genotypes and clinical data in patients carrying the R143W variant on an allele indicated that severity of hearing loss depends largely on the levels of dysfunction of the pathogenic variant on the allele, whereas a patient with the homozygous R143W variant demonstrated profound hearing loss. We concluded that the R143W variant causes structural destabilization of protein of GJB2.
Combined Exposure to Multiwalled Carbon Nanotubes and Dibutyl Phthalates Aggravated Airway Inflammation in Rats
Authors: He Suli , peng haiyan , Wu Min , Yan Chao , Wan Jian , ye xin , Zhang Hongmao , Ding Shumao
Published: August 2023

Previous work has shown that mice exposed to DBP-adsorbed onto MWCNTs, via tail vein injection, displayed black lesions in their lungs. To investigate the mechanism causing this toxicity in the lung tissue of rats, we performed an experiment with SD rats, exposing them to DBP adsorbed onto MWCNTs via a tail vein injection for 14 days. The results revealed pulmonary edema and greyish-black lung tissue in the MWCNTs and the MWCNTs + DBP combined exposure groups. In the combined exposure group there was evident alveolar fragmentation and adhesion, and lung tissue sections showed significant levels of black particles. Sections of the non-cartilaginous region of the trachea had significant folding of the pseudostratified ciliated columnar epithelium and marked thickening of the submucosa. In BALF, the number of WBC, Lym, Neu, and Eos cells, as well as levels of IgE, IL-6, TNF-α, and IL-1β, were all significantly higher. TNF-α, IL-6, STAT3, and α-SMA mRNA expression were all elevated in the lung tissue. The combined exposure group, which had considerable airway remodeling, had a greater degree of tracheal constriction and luminal narrowing, according to the results of the α-SMA immunofluorescence assay. According to these experimental findings, the exposure to both MWCNTs and DBP seemed to have a synergistic effect and exacerbated rats' impaired respiratory function that resulted from exposure to MWCNTs alone.
Genes and pathways underpinning Klinefelter syndrome at the single-cell level
Authors: Tian Linlin , Yu Yan , Mao Ziqing , Xu Dandan , Zhang Hongbo , Qiao Mengkai , Chen Tong , Liu Wen
Published: August 2023

Klinefelter syndrome (KS) is the most frequent genetic anomaly in infertile males. Despite this, the molecular mechanisms involved in KS are poorly defined. Based on bulk transcriptome and single-cell RNA sequencing datasets with peripheral blood monocyte (PBMC) sample(s) from healthy and KS men, this study was designed to address critical genes and pathways correlated with the occurrence of KS. Through a comparison between control and KS samples, we obtained 5 hub genes, including two upregulated genes (XG and ITLN1) and three downregulated genes (DEFA4, BPI and MPO). Without exception, these five genes yielded an excellent discriminatory capacity for KS with an area under the receiver-operator-characteristic curve over 0.75. We also assessed between-group differences of immune cell infiltration using ssGSEA. Infiltrated degree of some immune cells such as CD56bright NK cell was found to be positively associated with the expression of ITLN1 and XG. Through Kyoto Encyclopedia of Genes and Genomes enrichment, we identified PI3K/AKT pathway and neuroactive ligand-receptor interaction as upregulated pathways for KS. Gene set enrichment analysis together with gene set variation analysis confirmed upregulation of G2M checkpoint, mitotic spindle, and heme metabolism for KS. Furthermore, scRNA-seq data analysis was conducted to detect intercellular communication between different immune cell types, and a strong correlation was detected for macrophages, dendritic cells or NK cells with the other cell types. Collectively, we provided hub genes, pathways, immune cell infiltration degree, and cell-cell communication interactions for KS, warranting novel insights into the mechanisms of KS.
Multi-cell resonant boost converter based off-grid solar-PV system
Authors: Maurya Ajay Kumar , Das S. K. , Singh Dinesh Kumar , Chandra Isha
Published: August 2023

This paper presents an application of a multi-cell resonant boost converter as an MPPT device for solar PV off-grid systems. The paper also presents the comparison of the theoretical efficiency of a multi-cell resonant boost converter with a traditional boost converter used as an MPPT or high gain boost devices for solar PV – battery backup off-grid AC systems on various factors such as power, duty cycle, and frequency. It is concluded that a multi-cell resonant converter improves the system's overall efficiency by Zero Current Switching (ZCS). Furthermore, an energy management scheme is proposed for power generation management. The energy management scheme performs the following tasks: regulate power generation by MPP and non-MPP mode of operation, regulate power consumption by battery charging current control and load shedding, and ensure power supply to baseload (lean power demand). MATLAB 2021a is used for the simulation, and dSPACE DS1104 based controller is employed to run the experimental prototype. The simulation and experimental prototype results are presented to validate the theoretical concepts. The paper concludes that the multi-cell resonant boost converter is efficient, and performs successfully at various power regulation tasks therefore, the multi-cell resonant boost converter is a better choice over a traditional boost converter for solar-PV off-grid systems.