bluuebunny/crossref_metadata_2025 huggingface dataset:
Contemporary Distribution of High-Grade Prostate Cancer in the Circumstances of Opportunistic Testing
Authors: Stojadinovic Milorad M , Pantic Damjan N , Stojadinovic Miroslav M
Published: January 2019

Screening has dramatically changed the distribution of the mean age, stage and grade of prostate cancer (PCa) at diagnosis. However, regional-level data that characterize contemporary PCa patients are limited. The aim of the study was to ascertain main clinical and pathological characteristics of PCa at the present time in the circumstances of opportunistic testing.

High-grade PCa according to age, serum prostate specific antigen (PSA), volume prostate, PSA density (PSAD), digital rectal examination (DRE) number of positive cores biopsies and the average percentage of cancer in biopsy at diagnosis has been retrospectively evaluated in 100 men with biopsyproven PCa, at Clinical Centre Kragujevac, from September 2016 until September 2017. PCa were stratified according to Gleason score (GS) into low/intermediate-grade (GS ≤ 7) and high-grade (GS ≥ 8). To identify the determinants associated with high-grade PCa, we performed univariate and multivariate logistic regression.

The most prevalent PCa were the low/intermediate-grade (65%), followed by high-grade (35%). The mean age of the patients was 71.5 (range: 56–88) years and median PSA was 14.6 (range: 1.4–935) ng/ml. There were significant differences in age, PSA, PSAD, DRE, number of positive biopsy and average percentage of cancer in biopsy between patients with or without high-grade GS. Logistic analysis demonstrated the PSAD and age have strong prognostic value of high-grade PCa.

In conclusion, our study has shown the worrying frequency of high-grade PCa in the circumstances of opportunistic testing. Older men and higher level of PSAD had a much higher probability of high-grade PCa.
Mesenchymal Stem Cells Attenuate Acute Liver Failure by Promoting Expansion of Regulatory T Cells in an Indoleamine 2,3-Dioxygenase-Dependent Manner
Authors: Miloradovic Dragana , Miloradovic Dragica , Jankovic Marina Gazdic , Markovic Bojana Simovic , Harrell C. Randall , Fellabaum Crissy , Arsenijevic Nebojsa , Lukic Aleksandra , Volarevic Vladislav
Published: January 2019

The influence of mesenchymal stem cells (MSCs) on the phenotype and function of CD4+CD49b+FoxP3- regulatory cells has not been elucidated. We used Concanavalin A (ConA) - and α-galactosylceramide (α-GalCer)-induced acute liver injury to estimate the effects of MSCs on liver-infiltrating CD4+CD49b+FoxP3-regulatory cells. MSCs significantly reduced ConA- and α-GalCer-mediated liver injury in C57BL/6 mice, as demonstrated by biochemical tests, reduced influx of inflammatory CD4+ T cells, and increased presence of CD4+CD49b+FoxP3- regulatory cells in the injured livers. The number of CD4+CD49b+FoxP3-regulatory cells was also significantly increased in α-GalCer-treated mice that received MSC-derived conditioned medium (MSC-CM). The presence of 1-methyltryptophan, a specific inhibitor of indoleamine 2,3-dioxygenase (IDO), in MSC-CM completely abrogated the hepatoprotective eff ect of MSCs and significantly decreased the total number of liver-infiltrated CD4+CD49b+FoxP3- regulatory cells, indicating the crucial importance of MSC-derived IDO for the expansion of CD4+CD49b+FoxP3- regulatory cells and the consequent MSC-dependent attenuation of acute liver injury.
Redox Status in Women with Rheumathoid Arthritis
Authors: Vranic Aleksandra , Antovic Aleksandra , Draginic Nevena , Andjic Marijana , Ravic Marko , Jakovljevic Vladimir , Veselinovic Mirjana
Published: January 2019

The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation – thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as anti-oxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased su-peroxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.
Antitumor Effect of the Chalcone Analogue, (E) -1-(4-Ethoxy-3-Methoxyphenyl) -5- Methylhex-1-En-3-One on HeLa Cell Line
Authors: Lukovic Jovan , Mitrovic Marina , Zelen Ivanka , Čanovic Petar , Zaric Milan , Nikolic Ivana
Published: January 2019

Chalcones represent precursor compounds for flavonoids biosynthesis in plants. Chalcones, 1,3-diaryl-2-propen-1-ones, have unique chemical structure with conjugated double bonds and delocalized π-electron system on both aromatic rings. Various studies have shown that chemical structure of chalcone is responsible for their antitumor effect. In our study, we have examined the antitumor effect of chalcone analogue (E) -1- (4-ethoxy-3-methoxyphenyl) -5-methylhex-1-en-3-one (CH) on HeLa cells. The antitumor efficiency of different CH concentrations was compared to the antitumor effects of dehydrozingerone and cisplatin. The viability of the cells was evaluated using MTT assay; type of the cell death was evaluated by Annexin V-FITC/7-AAD staining using FACS analysis; morphology changes of treated cells were visualized and compared to untreated cells using phase contrast microscopy. The result of our research showed that CH have a stronger antitumor compared to the effect both of dehydrozingerone and cisplatin. Our results indicated that chalcone analogue induced cell death via activation of apoptosis more powerfully compared to the apoptosis induced with dehydrozingerone and cisplatin.
Ten Marathons in Ten Days: Effects on Biochemical Parameters and Redox Balance – Case Report
Authors: Pesic Deniel , Srejovic Ivan , Stefanovic Djordje , Djordjevic Dusica , Cubrilo Dejan , Zivkovic Vladimir
Published: January 2019

Production of free radicals and oxidative damage during physical activity is a topic that is intensively studied and paid a lot of attention, first of all in professional sports. Marathon is categorized as extremely demanding sports discipline, as it induces high energy consumption and also requires special mental self-control. We presented cases of two athletes of different age, who have been on dissimilar level of sports readiness, and also had various approach to physical activity and exercise. During 10 days they ran out 10 marathons, partly on a flat terrain, and partly on hilly, which produced different level of effort in conquering the terrain. Also, both athletes had complex supplementation scheme in order to prevent electrolyte imbalance and excessive production of free radicals. Blood samples were taken in the morning and immediately after the end of the marathon. Measured oxidative stress biomarkers changed without a noticeable pattern, but these changes did not vary greatly among themselves. Catalase activity in both marathon runners was higher after marathon almost after every race for 10 days. On the other hand, amount of reduced glutathione was lower after marathon in both athletes in the same manner. Based on the obtained results we can conclude that adequate supplementation could have crucial role in prevention of oxidative damage.
Cystic Lesions of Anterior Mediastinum: Case Report
Authors: Lukovic Ana , Arsenijevic Milos , Milisavljevic Slobodan , Stojkovic Dragan , Mrvic Stanko , Radovanovic Dragce
Published: January 2019

Cystic lesions of the mediastinum are uncommon, comprising 12% to 18% of all primary mediastinal tumors and unless they attain a large size and cause compressive symptoms, these tumors are generally asymptomatic and are discovered incidentally upon radiologic investigation of some other condition.

We present in this paper a case of cystic lesions of the mediastinum in a 70-year-old male patient who underwent a surgery for mediastinal mass removal. Histopathology report had shown it was the case of mature cystic teratoma of anterior mediastinum.

Based on a review of the literature, as well as our experience, we conclude that best treatment for cystic lesions of anterior mediastinum is complete surgical resection if possible.
Effect of Behavioural Interventions for Obesity Prevention in Pregnancy on the Adequacy of Gestational Weight Gain and Retention: Metabolic Health of Indian Women
Authors: Pawalia Alka , Кulandaivelan Sivachidambaram , Savant Satya , Yadav Vikram Singh
Published: January 2019

The aim of this study was to measure the adequacy of gestational weight gain (GWG) in Indian women using various behavioural interventions during pregnancy, which primarily aim to observe the effects on obesity markers and weight retention.

In this experimental study, one hundred and forty pregnant women underwent interventions in 5 groups, control (C), diet (D), home exercise (HE), supervised exercise (SE) and supervised exercise with diet (SED), from pregnancy through delivery with 2 months follow-up post-delivery. The outcome measures were GWG and baby birth weight.

A one-way ANOVA indicated no differences in the mean GWG between groups (12.39±4.71 kg, p=0.947). The control group had the most (50%) and both the supervised exercise groups had the fewest (32%) women who gained above the recommended GWG, followed by the diet group (33.3%). The D and HE groups had the most women who gained within the GWG range, while both the SE and SED groups had the most women who gained below the GWG range. However, these results did not affect the birth weight between the groups (mean 2.96 kg±0.40, p=0.203). In women with normal BMIs, (18.5-22.9 kg/m2), the diet group had the most effective maintenance of adequate GWG, with 15%, 55%, and 30% of the women gaining above, within, and below the recommended GWG, respectively. The SE and SED groups had the least postpartum weight retention (PPWR) at 2 months, followed by the HM, D and C groups; i.e., the results showed a trend in the desired direction clinically, although they were not statistically significant (p=0.12).

Supervised exercise can be effectively used as a pregnancy intervention to prevent excess GWG in Indian women. Diet counselling was found to be the next best intervention in combination with exercise, as well as for women with normal BMI.
PENGARUH IKLIM ORGANISASI TERHADAP KOMITMEN ORGANISASIONAL DAN RETENSI PEGAWAI KONTRAK DI BAPPEDA LITBANG PROVINSI BALI
Authors: Cahyadi Meliana Kurniawati , Utama I Wayan Mudiartha
Published: January 2019

Retensi adalah elemen penting dari pendekatan organisasi. Setiap organisasi hendaknya berupaya mempertahankan karyawannya terutama karyawan yang memiliki nilai penting bagi organisasi. Mempertahankan bakat profesional terbaik adalah praktek sangat penting bagi organisasi seperti mengeliminasi rekrutmen, seleksi dan mengurangi biaya dari pergantian mereka, dan menjaga kontinuitas sesuai bidang keahlian mereka. Penelitian ini bertujuan untuk mengetahui pengaruh iklim organisasi terhadap komitmen organisasional dan retensi pegawai kontrak di Bappeda Litbang Provinsi Bali dengan menggunakan 66 orang sebagai responden penelitian. Teknik penentuan sampel yang digunakan dalam penelitian ini adalah menggunakan teknik sensus. Pengumpulan data dilakukan melalui wawancara dan kuesioner. Teknik analisis data yang digunakan pada penelitian ini adalah path analysis yang diolah menggunakan software SPSS. Hasil yang diperoleh dalam penelitian ini menunjukkan bahwa iklim organisasi memiliki hubungan yang positif dan signifikan terhadap komitmen organisasi, iklim organisasi memiliki hubungan yang positif dan signifikan terhadap retensi dan iklim organisasi memiliki hubungan yang positif dan signifikan terhadap retensi.

Kata kunci : iklim organisasi, komitmen organisasional, retensi.
PENGARUH KEPUTUSAN INVESTASI, KEPUTUSAN PENDANAAN DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN FOOD AND BEVERAGES
Authors: Utami Asri Pawestri Setyo , Darmayanti Ni Putu Ayu
Published: January 2019

Companies that want to maximize the value of the company, will take some decisions such as investment decisions, dividend policies, and funding decisions. The purpose of this study is to explain the effect of investment decisions, funding decisions, and dividend policy on the value of food and beverages companies listed on the Indonesia Stock Exchange. The samples used in this study were selected in saturation sampling. Secondary data obtained then selected based on predetermined criteria, then obtained as many as 13 sample during period of year 2013-2016. Data analysis technique used is multiple linear regression analysis. The results showed that investment decisions, funding decisions, and dividend policies have a positive and significant impact on the value of food and beverages companies. The suggestion that can be given is to pay more attention to internal factors of the company. These variables can be used as a reference to establish a strategy in increasing the value of the company. Good corporate value shows the level of good corporate financial health so as to make the value of the company will be increased and in demand by investors.

Keywords: Investment Decision, Fund Decision, Dividend Policy, Corporate Value
PERAN BRAND IMAGE DALAM MEMEDIASI PENGARUH HARGA TERHADAP NIAT PEMBELIAN (Studi Pada Produk Iphone Di Kota Denpasar)
Authors: Rahma Putra AA Gd Agung , Aksari Ni Made Asti
Published: January 2019

The purpose of this study is to examine the effect of price on brand image, the effect of price and brand image on consumer purchase intention, and the role of brand image in mediating the effect of price on the purchase intention towards iPhone product in Denpasar City. The population of this study are consumers with the intention to use iPhone product. The sampling method used in this study is nonprobability sampling with purposive sampling technique by using certain consideration. The sample selected for this study was 110 respondents. Data is analysed using path analysis technique. The result of this research shows that price have a positive and significant effect on iPhone brand image, price and brand image have positive and significant effect on consumer purchase intention towards iPhone product, and brand image plays a mediating role on the relationship between price and purchase intention towards iPhone product in Denpasar.
The Urgency of Regulatory Reform in Order to Support Indonesia’s National Development
Authors: Setiadi Wicipto
Published: January 2019

Poor regulation quality contributes negatively to the regulation and law enforcement in the life of the state. The indicator of the poor quality of regulation includes, among others, the large number of regulations requested for judicial review and effectiveness of the implementation of regulations. There are several regulatory issues in Indonesia today, including the existence of multiple interpretations; potential conflict; overlap, principle mismatch, weak implementation effectiveness, not harmonious/out of sync; inconsistent; create unnecessary burdens, both on the target group and the affected groups. Base on these regulatory conditions, regulatory reform is very important and urgent. Given this very basic regulatory issue, it is necessary to make improvements in the regulatory field from upstream to downstream which leads to quality, orderly and simple regulations known as regulatory reform. The purpose of the study is to examine regulatory reform in order to support Indonesia's national development. research is done by doing literature research, or commonly known as the literature study. The Study shows that in order for a regulation to be good, it must fulfill several principles, namely: good norm, good process, and good drafting. Regulatory reform implementation is carried out through a) simplification of existing regulations; b) reconceptualization of the procedures for establishing regulations; c) institutional restructuring of regulation formation; and d) strengthening/empowering human resources with integrity. Good quality of democratic political dimension and progressive legal quality are needed to improve the quality of regulation
New Priorities for Dairy Cows Feed Production System Using Fuzzy-AHP
Authors: Prameswari Puspa Ayu Indah
Published: January 2019

Management criteria can be used as the deciding device of the performance of dairy cows feed production system successfulness by prioritizing those criteria, and it can be used as an improvement step. The aim of this study was to determine the priority of management criteria and established the improvement step to increase the performances of the dairy cows feed production system in Batu, East Java by prioritizing four management criteria (Planning, Organizing, Directing, and Controlling). The method used the Fuzzy Analytic Hierarchy Process (Fuzzy-AHP) which is a combination of two methods, Analytic Hierarchy Process (AHP) and fuzzy logic. Fuzzy AHP is proposing an evaluation tool which inherits advantages from that two methods. Fuzzy AHP will translate decisions makers comparison judgment into the fuzzy number. There were three highest priorities for management criteria, namely goal planning for the long-term from planning criteria, divisions of work from organizing criteria, and activator from controlling criteria. It was concluded that those three highest management criteria could be established as an improvement step for the performances of dairy cows feed production system.
Penerapan Metode Analytical Hierarchy Process pada Rekomendasi Keputusan Pemilihan SIM Card Provider
Authors: Subiksa Gde Brahupadhya , Jasa Lie
Published: January 2019

Abstract—SIM card provider is the center of mobile telecommunication such as telephones, texting, Internet or Blackberry messenger. Lately, the SIM card business development is be marked more kinds of SIM card offered by the provider company with various brands, features and facilities. This causes consumers find it difficult to choose the SIM card that suits their needs such as the phone call need, texting need, Internet and Blackberry package, and bonus that the consumer wants. From the problems above, consumer need a decision support system that can gives SIM card recommendation which suits the consumer’s needs. The SIM card provider decision-making selection can be complex because of the multiple purposes of consumer. One of the tools that are suitable to use for SIM card sorting priority is Analytic Hierarchy Process (AHP) that is developed by Thomas L. Saaty. The final result from this thesis is a system of SIM card provider selection decision-making support which suits with the consumer’s needs. The system is tested with data collection by using questionnaire, which aims to obtain data that is more accurate about the usefulness of the system that has been created. Data collection are through the 30 respondents who tried the system from the user side and 5 respondents who filled out questionnaires from the administrator side. The results of the data collection and analysis of data collected declare that this system has its deficiency, especially the difficulty of priority weighting of both.
The Meanings of "Kanashii" and "Kurushii" from the Perspective of Kanji Writing and Their Uses in Japanese Sentences
Authors: Indra Pradhana Ngurah
Published: January 2019

This research is entitled "The Meanings Of  "Kanashii" And "Kurushii" From The Perspective Of Kanji Writing And Their Uses In Japanese Sentences." This title was chosen as a research topic because it is still rare to conduct their research that analyzes the meaning of adjectives, especially the synonymous adjective by reviewing the formation of kanji. There are not many people know, especially for Japanese language learners and is very interesting to stimulate new research variations. us with the exact aspects of their meaning with a review of the formation of kanji. The method used in this study consists of a method of referring to data collection by tapping techniques. In the next practice, this tapping technique is followed by advanced techniques in the form of techniques of recording and techniques of uninvolved conversation technique. The technique of note is to record things that are considered important. The method used to analyze the data is the method of agih (distribution method). The last stage is the presentation of the results of analysis by using formal and informal methods. It is done so that the readers understand the research results more clearly. The theory used in this research is about kanji and its formation, synonym theory, and theory of contextual meaning. With these theories study are that the readers are given differences in the use of two synonyms words in Japanese with cultural nuances they have.
Archaeological Artifacts at Cultural Village Regionof Kemoning, Klungkung
Authors: Herawathi Ni Wayan
Published: January 2019

The research toward archaeological artifacts at Cultural Village region of Kemoning aims to reconstruct every aspect of life (history, behavior and cultural process) of society in the past, so that people may recognize, understand, comprehend everything about their villages, growing a confidence on living in villages, and join to participate in cultural preservation step in the future. Cultural village of Kemoning has many archaeological artifacts and cultural/ traditional values which still applied in community. Meanwhile its artifacts, like statues, sacred stones/prehistoric stones, inscriptions made of copper and palm leaves, puppet reliefs in the walls, ancient place of worships (pelinggih), temples’ gates (paduraksa and symmetrical arches (candibentar)), creese/spears, etc. Artifacts/statue relics in this village is quite many, with various figures being made statues, among others Trimurti statues (Brahma, Vishnu, Shiva), ascetic statues, Bhatara di gumi statues (statue/manifestation of ancestors of Kemoning village riding horses), naked statues believed as the symbol of fertility/ expectation for babies, pennant statue as god of art (dance, etc.), statues of gods/ goddess, statue of Ganesha, and statues of other figures. Cultural village of Kemoning has many ancient temples, among others: temple of KahyanganTiga, temple of Dang Kahyangan, temples which its location as crossers (penyirang) (northeast, southeast, northwest, and southwest), temples of kawitan, temples of paibon, and many more of shrines (pelinggih/penyiwianbhatara). The position of these temples which show pattern position directing to every corner of compass’ point raises hypothesis by the author , that is whether at that time the teaching of SiwaSidhanta had developed? And whether people of Kemoning at that time had recognized the concept of “mandala” in designing/setting their village? Also, to determine what is the best cultural concept to be maintained/developed in the future?. In addition, Kemoning village also has a set of magical ancient gong, subak/ pekaseh system, tradition of magibung, tradition of ngayah, ngupadesa, ngusabanini, and kinship with other communities in other regions. Various ancient contents owned by Kemoning community, therefore it is necessary to be revealed specifically, to be known by people, our offspring and public.
Problems and ways of improving the efficiency of surgical treatment of hiatal herniae
Authors: Vasilevskii D. I. , Dvoretskii S. Iu. , Tarbaev I. S. , Akhmatov A. M.
Published: January 2019

The objectiveof the study is to consider the main problems and to define the ways to improve the efficiency of surgical treatment of hiatal herniae.

Material and methods.518 patients were operated, the plasty of hiatal hernia – posterior cruroraphy – was carried out in 191 (26.9%) of patients, the prosthetic materials via the method «mesh-reinforced» were used in 327 (63.1%) of patients.

Results. The general surgical complications were noted in 43 (8.3 %) patients, the delayed side effects were in 118 (22.8 %) patients, relapse of hiatal hernia were in 27 (5.9 %) patients.

Conclusion.The high frequency of relapses remains the main problem in surgery of hiatal hernia.
The role of videothoracoscopy and pleurodesis in the diagnosis and treatment of inflammatory pleural effusions
Authors: Plaksin S. A. , Farshatova L. I.
Published: January 2019

The objectiveof the study is еo evaluate the possibilities of videothoracoscopy in the cases of pleurisy of inflammatory nature of specific and non-specific etiology.Material and methods.We carried out the retrospective analysis of medical histories of 135 patients.. Parapneumonic pleurisy was diagnosed in 68 (54.4 %) patients, tuberculous pleurisy – in 57 (45.6 %) patients.Results.Videothoracoscopy was diagnostic procedure in 61.6 % of patients and was performed for the defragmentation of pleurisy in 38.4 % of patients. Videothoracoscopy allows exactly diagnosing the tuberculous pleurisy by means of biopsy in the absence of lesions on the pleura. Resistant parapneumonic pleurisy was diagnosed in 34.9 % of patients. In cases of parapneumonic resistant pleurisy, the pleurodesis reduces the time of the drainage by means of injection through the drainage of mixtures of betadine and concentrated solution of glucose.
Arthroplasty of protrusion coxarthrosis in the patient with end-stage renal disease
Authors: Tsed A. N. , Dulaev A. K. , Mushtin N. E. , Iliushchenko K. G. , Shmelev A. V.
Published: January 2019

The article describes the observation of successful total hip arthroplasty of protrusion coxarthrosis in the patient with end-stage renal disease.
Diskriminierung von Senioren – Fakten über und Wege für das würdige altern
Authors: Morciniec Piotr
Published: January 2019

Obecne stulecie przedstawiane jest często jako wiek starzenia się. Nieproporcjonalne zwiększanie się grupy ludzi starych, do prawie jednej czwartej społeczeństwa niesie ze sobą nie tylko dumę z osiągnięć medycyny przedłużającej życie, lecz także negatywne trendy społeczne. Postępujące procesy, które zostały już określone jako „desolidaryzacja międzygeneracyjna”, znajdują swój wyraz także w bardzo negatywnych zjawiskach, wśród których na znaczenia nabiera dyskryminacja osób starszych. Bazujące na stereotypach i uprzedzeniach negatywne nastawienie do najstarszej części społeczeństwa budzi niepokój i domaga się poszukiwania dróg wyjścia. W niniejszym opracowaniu na podstawie analizy polskojęzycznej literatury fachowej starano się uporządkować przyczyny i konteksty takich negatywnych odniesień do seniorów, wskazano najistotniejsze obszary dyskryminacyjne, aby na koniec zapytać o możliwe wyjścia z sytuacji nierówności społecznej, której doświadczają ludzie starzy. Przesłanie tekstu pozostaje pozytywne, gdyż potrzeba poszukiwać nowych dróg solidarności i dialogu międzygeneracyjnego, pamiętając że priorytetowym zadaniem pozostaje wzmocnienie silnej rodziny, która pozostaje najbardziej sprawdzona ostoją godności osób najsłabszych, do których seniorzy niewątpliwie należą.
Transport Anomalies Emerging from Strong Correlation in Ionic Liquid Electrolytes
Authors: Molinari Nicola , Mailoa Jonathan P. , Craig Nathan , Christensen Jake , Kozinsky Boris
Published: January 2019

Recent works on ionic liquid electrolyte systems motivate the present study of transport regimes where strong species interactions result in significant correlations and deviations from ideal solution behaviour. In order to obtain a complete description of transport in these systems we use rigorous concentrated solution theory coupled with molecular dynamics simulations, beyond the commonly used uncorrelated Nernst-Einstein equation. As a case study, we investigate the NaFSI - Pyr13\FSI room temperature ionic liquid electrolyte. When fully accounting for intra- and inter-species correlation, an anomalously low and even negative transference number emerges for NaFSI molar fractions lower than 0.2, emphasising that strong ion-ion coupling in the electrolyte can significantly impact the rate performance of the cell. With increasing concentration the transference number monotonically increases, approaching unity, while the total conductivity decreases as the system transitions to a state resembling a single-ion solid-state electrolyte. The degree of spatial ionic association is explored further by employing a variant of unsupervised single-linkage clustering algorithm. Using this combination of numerical techniques we examine the microscopic mechanisms responsible for the trade-off between key electrolyte transport properties, previously overlooked in both computational and experimental studies.
Introducing QUBE: Quantum Mechanical Bespoke Force Fields for Protein Simulations
Authors: Allen Alice , Robertson Michael J. , Payne Michael C. , Cole Daniel
Published: January 2019

Molecular mechanics force field parameters for macromolecules, such as proteins, are traditionally fit to reproduce experimental properties of small molecules, and thus they neglect system-specific polarization. In this paper, we introduce a complete QUantum mechanical BEspoke (QUBE) protein force field, which derives non-bonded parameters directly from the electron density of the specific protein under study. The main backbone and sidechain protein torsional parameters are re-derived in this work by fitting to quantum mechanical dihedral scans for compatibibility with QUBE non-bonded parameters. Software is provided for the preparation of QUBE input files. The accuracy of the new force field, and the derived torsional parameters, are tested by comparing the conformational preferences of a range of peptides and proteins with experimental measurements. Accurate backbone and sidechain conformations are obtained in molecular dynamics simulations of dipeptides, with NMR J coupling errors comparable to the widely-used OPLS force field. In simulations of five folded proteins, the secondary structure is generally retained and the NMR J coupling errors are similar to standard transferable force fields, although some loss of the experimental structure is observed in certain regions of the proteins. Overall, with several avenues for further development, the use of system-specific non-bonded force field parameters is a promising approach for next-generation simulations of biological molecules.
EPISTEMOLOGIAS DO SUL APLICADAS NO CONTROLE CONCENTRADO DE CONSTITUCIONALIDADE BRASILEIRO
Authors: Oliveira Wagner Vinicius de
Published: January 2019

Nesse escrito traça-se as linhas iniciais para a alteração do estado de coisas conhecido como “colonialidade do saber” aplicado no controle de constitucionalidade brasileiro. O primeiro passo é compreender que o fenômeno jurídico na contemporaneidade reclama pelas participações sociais, nesse sentido o foco recai sobre a aproximação entre o pensamento decolonial e o sentido material da Constituição. Para tanto, essa pesquisa bibliográfica serve-se do método de análise documental com o objetivo de investigar as condições de possibilidades oferecidas pelas epistemologias do Sul para o controle de constitucionalidade brasileiro. Os resultados obtidos apontam para uma inclusão epistemológica de saberes outros numa nova racionalidade, democrática e inclusiva, bem por isso, sugere-se a virada epistemológica contida no título do presente artigo. Em conclusão, vê-se que o hemisfério Sul, do lado ocidental do mundo, se encontra permeado (dependente) das interpretações que, de outra sorte, deveriam ser suas.
CRISE CONSTITUINTE: as reformas administrativas e os ajustes fiscais no contexto do estado de exceção econômico
Authors: Borba Daniel Allan Miranda
Published: January 2019

Com o aprofundamento da crise fiscal e da própria crise do Estado na década de 1990, além da ineficiência do serviço público, as “transformações” trazidas pela Constituição Federal de 1988 não foram acompanhadas das necessárias mudanças normativas, institucionais e culturais, de forma que não logrou romper com a pecha da corrupção e ausência que caracteriza o Estado brasileiro. Os governos pós-Constituição de 1988 imprimiram as marcas do neoliberalismo através de profundas mudanças constitucionais que, atualmente, inviabilizam as promessas constitucionais, através da implementação de um Estado mínimo, desengajando-se do Estado de Bem-Estar social a partir do foco no ajuste fiscal. Este artigo se propõe a demonstrar que as reformas constitucionais que têm como base o ajuste fiscal, sobretudo a Emenda Constitucional nº 95/2016, são promovidas em virtude do permanente estado de exceção econômico vivenciado especialmente pelos países da América Latina, o que acaba por desfazer os projetos originários previstos pelo poder constituinte, configurando-se na crise constituinte, porquanto as decisões são tomadas de acordo com a conveniência dos interesses econômicos e não de acordo com a vontade do povo. Para alcançar os objetivos aqui propostos, adotou-se a metodologia jurídica, o método descritivo, a pesquisa documental, a técnica da documentação indireta e a pesquisa bibliográfica.
PENINGKATAN KUALITAS AIR MINUM MELALUI METODE PENYARINGAN BERTINGKAT BERBASIS LIMBAH KULIT TELUR DI DESA TERU KABUPATEN BANGKA TENGAH
Authors: Asriza Ristika Oktavia , Pitulima Janiar , Fabiani Verry Andrei , Mahardika Robby Gus
Published: January 2019

In accordance Regulation Minister of Health Republic of Indonesia No. 492 / MENKES / PER / IV / 2010 about Quality Requirements of Water Drink, the acidity (pH) of water drink about 6.5 - 8. Based on situation analysis, Teru Village of Central Bangka Regency is below the standard, which about 4.1. The low pH of water drink in Teru village cause negative effect for health. So, an effort to improve the quality of water drink is needed. Through IbM Devotion of Society was created by filtration tool on eggshell-based waste in Teru Village, Central Bangka Regency. By utilizing an egg shell waste containing calcium carbonate, it is expected to increase the pH of the water. Based on the results of trials in the field, the results obtained that there was an increase in the pH of water drink to 6.91, which is in accordance with drinking water quality standard.
El caminar de los genes y el reloj molecular: Realidad del Ecuador
Authors: Paz-y-Miño César , Zambrano Ana Karina , Leone Paola E.
Published: January 2019

La genética convencional y la molecular han acumulado suficientes datos sobre las poblaciones humanas mundiales; por ello, en la actualidad se puede desentrañar el origen fidedigno de cada grupo humano. Una serie de marcadores genéticos han permitido rastrear el origen y la migración humana. STRs, Indels, Mitocondrias, Cromosoma Y, entre los más usados, dan cuenta de la trayectoria de la humanidad y el poblamiento del planeta. La genética moderna nos muestra la composición poblacional de diversas variantes de genes y secuencias no informativas; asàpermiten hoy entender mejor y hasta clasificar grupos poblacionales como etnias. Aunque, el ADN es el mismo para todos los humanos, secuencias no esenciales muestran diferentes frecuencias de presentación según el grupo étnico. Adicionalmente, a través del estudio de los marcadores genéticos, podemos calcular los tiempos migratorios y el momento del origen y expansión de los humanos; lo que se llama el reloj molecular. Este artículo aborda algunos de los conocimientos actuales en genética poblacional, etnicidad y tiempos genéticos, incluso, presenta datos reales de análisis del ADN.
GENE POOL OF NATIVE BREEDS OF LIVESTOCK IN THE REPUBLIC OF SAKHA (YAKUTIA)
Authors: Ivanov R. V. , Romanova V. V. , Fedorov V. I. , Hompodoeva U. V.
Published: January 2019

The paper presents the results of many-year research into the origin, preservation and rational use of the genetic resources of native livestock breeds in the Republic of Sakha (Yakutia). These breeds are characterized by high adaptability to extreme housing conditions and severe environmental conditions. They are not exacting about feeding and are distinguished by high quality of the produce (milk, meat, sldn and products of their processing). The article analyzes natural climatic, historic, social and economic developmental characteristics of Yakut animal husbandry. The main stages of the concept implementation for breeding and raising cattle of the adapted type on the regional level are described. Themolecularandgeneticresearchtestify to the unique genetic structure of native livestock breeds (Yakut cattle, horses and reindeer). The genetic unique character and adaptability of Yakut cattle, horses and reindeer to the harsh conditions make them a valuable material for further breeding work and research into adaptation mechanisms.
ТЕОРЕТИКО-МЕТОДОЛОГІЧНИЙ АНАЛІЗ ФЕНОМЕНУ ЗАДОВОЛЕНОСТІ ЯКІСТЮ ЖИТТЯМ ЯК УМОВИ РОЗВИТКУ ПРОФЕСІЙНОЇ Я-КОНЦЕПЦІЇ ОСОБИСТОСТІ
Authors: Kliuiko Lesia
Published: January 2019

У статті розглянуто задоволеність якістю життя як одну з головних умов розвитку професійної Я-концепції особистості. Задоволеність якістю життя визначається, насамперед, досягнутими цілями, подоланими труднощами, змінами, що відбуваються в особистому й професійному житті, а на рівень задоволеності життям впливає весь комплекс характеристик, пов’язаних із невротизмом. Наше проаналізовано останні дослідження, що стосуються феномену задоволеності життям, у світовій і вітчизняній літературі, висвітлено проблеми формування та розвитку поняття Я-концепції в наукових працях учених-психологів. Я-концепція у внутрішньому світі людини та її самосві­домості зокрема – це важлива структурна складова частина психологічної самоорганізації, що виконує функцію передумови й наслідку ефективності соціальної взаємодії і якості життя в цілому та виявляється як відносно усталена, динамічна й певною мірою усвідомлена система уявлень особи про саму себе.

Також презентовано теоретичне дослідження задоволеності життям як однієї з умов розвитку професійної Я-концепції особистості та визначено, що задоволеність життям є складним психологічним поняттям. Виділено різні компоненти й фактори задоволеності якістю життя. Я-концепція формується за етапами соціалізації та має індивідуально-природне спричинення й виникає в процесі розгортання соціальної взаємодії як результат її культурного розвитку, а відтак є відносно стійким і водночас піддатливим до внутрішніх коливань та змін психічним новоутворенням. Окрім того, Я-концепцію описують із боку змісту й характеру уявлень про себе, складності та диференційованості цих уявлень, їх суб’єктивної важливості для особистості, а також внутрішньої цілісності й послідовності, узгодженості, стійкості в часі.
Choosing the Right Words: Interpreting Rent Review and Renewal Clauses in Commercial Leases
Authors: Menzies Gary R.
Published: January 2019

This article examines the various ways that courts have interpreted rent review and rent renewal clauses in commercial leases. Both the subjective and objective approaches are discussed and cases illustrative of these approaches are examined. The author then outlines the implications of restriction on use clauses in this area; case law is discussed and practical drafting hints are suggested. Finally, sample rent renewal clauses are provided, favourable to both landlord and tenant respectively.
International Commercial Arbitration and the Canadian Experience
Authors: Haigh David R. , Kunetzki Alicia K. , Antony Christine M.
Published: January 2019

International Commercial Arbitration although enjoying a long pedigree, has only recently become a "hot topic." This is due to the growing trends towards institutionalizing and unifying ICA processes.
These trends are signified by the rise in private, neutral arbitration institutions and by the adoption, in many states, of international conventions and model laws. The unification of laws is the most recent process in this trend.
These trends are all examined in some detail. It is noted how the lex arbitri, or law of the situs of the arbitration, can affect the rules and procedures of the arbitration. The UNCITRAL Model Law is examined as the key example of the unification of laws movement. The alternative dispute resolution provision of NAFTA is also commented on.
The authors then focus specifically on Canada's contributions to and participation in ICA. In an important closing section, Canadian jurisprudence interpreting the new Canadian ICA legislation is comprehensively surveyed. The authors conclude by giving an outlook on the future of ICA and Canada's role therein.
Combatting Racist Speech: The Canadian Experience
Authors: Elman Bruce P.
Published: January 2019

This article traces a decade of Canadian jurisprudence on hate speech and Holocaust denial historical revisionism. It first compares the cases of Keegstra and Zundel and examines the constitutionality and efficacy of Criminal Code sections 319(2) and 181 as invoked in each case respectively. The article then examines alternative methods to the imposition of criminal sanctions for addressing the problem of hate propaganda. The cases of Malcolm Ross, John Ross Taylor and the Aryan Nations are reviewed in order to evaluate the use of human rights legislation to combat hate speech. The author concludes that while it is important for Canada to maintain criminal legislation, human rights legislation has some considerable advantages over criminal sanctions. Human rights hearings are less expensive, less time-consuming, and less complicated than criminal proceedings. Further to this, the standard of proof is the civil standard of balance of probabilities, and intent to harm need not be proven as in a criminal trial. Finally, the author gives a reminder of the value of education as an effective method of both minimizing the credibility of the hate-monger's message, and decreasing the susceptibility of the public to such messages.
Shall, Must, May: The Logic of Legal Obligation and Permission
Authors: Russell Ben
Published: January 2019

This article seeks to place legal drafting into a structured, logical system. It divides legal sentences into those which confer obligation or permission (called "performatives"), and those which describe obligation or permission (called "deontic declaratives"). It adopts George Coode's views as to the grammatical form of performatives. It then attempts to classify the logical relations between the various types of sentences. The relation holding between deontic declaratives is the traditional relation of "entailment"; the relation holding between performatives is a new relation the author calls "covering". In the case of performatives that impose obligations ("imperatives"), covering relations mirror entailment relations. The situation is more complicated for performatives that grant permission ("permissives"). The author attempts to analyze permissives in terms of providing defences to claims. He finds that covering relations between permissives do not mirror entailment relations. To this, and to confusions between performatives and declaratives, the author attributes various "paradoxes of permission." The author observes that the results of inconsistent drafting are "quandaries" in which a person is both obliged to perform an act and is prohibited from performing it. Despite current trends toward plain language drafting, the author endorses Coode's view that logical analysis is the key to improving legal drafting.
Recent Developments in Italian Constitutional-Criminal Law
Authors: Cadoppi Alberto
Published: January 2019

This article compares Italian "Constitutional- Criminal" law under Italy's Constitution with the development of legal rights in Canada under the Canadian Charter of Rights and Freedoms. The author explains the "constitutional approach'' to criminal law in Italy, which is a complex web of principles which govern the criminal law by defining the concepts of "crime" and "criminal responsibility". Professor Cadoppi then examines various aspects of "constitutional-criminal "law as it has been developed by legal scholars, and the extent to which this approach has been accepted by the Italian Constitutional Court. The legal rights found in "constitutional-criminal" law are thought to be extendable to Canadian constitutional law, given the broad language of section 7 of the Canadian Charter of Rights. The author notes that the Supreme Court of Canada has given the Canadian Charter an expansive interpretation comparable to the Italian ' 'constitutional-criminal'' law approach, and uses this parallel to show that Canadian and Italian courts are moving toward a vision of a new criminal law in which ' 'fundamental justice'' will prevail.
Altering the Judicial Mind and the Process of Constitution-Making in Canada
Authors: Elman Bruce P.
Published: January 2019

This essay deals with the alteration of the Supreme Court of Canada's approach when confronted with alleged violations of civil liberties in the pre-Charter and post-Charter eras. It is noted that certain statutes, such as the Lord's Day Act, were upheld under the Canadian Bill of Rights, but have since been struck down under the Charter of Rights and Freedoms under relatively circumstances. The author asserts that the changes in the approach to civil liberties, and the changes in the Supreme Court's decisions, are the result of a change in judicial attitudes. Among the factors responsible for acting as a catalyst for this shift in attitude, the author identifies and discusses the change in "principle" resulting from the constitutionalization of rights and the concomitant change in the Courts role, the change in "personalities" resulting from changes in the composition of the Supreme Court, and the "process of constitution-making" used in entrenching the Charter, which gave more legitimacy to the Court's role as interpreter of the Constitution than did the Bill of Rights.
Repairs v. Replacement - New Directions out of the Quagmire
Authors: Jones, Q.C. Frank D.
Published: January 2019

The article reviews the problematic area in tax law as to whether to characterize an outlay as a "repair", which results in a fall tax deduction for the year of the outlay, or as a "replacement", which allows the amortizement of the outlay over a number of years. Professor Jones then discusses a new way to deal with this problem.
One More Battle to Fight: Trade Union Rights and Freedom of Association in Canada
Authors: Renouf Simon
Published: January 2019

Three key decisions of the Supreme Court of Canada in 1987 considered the availability of the Charter's guarantee of freedom of association as legal protection for trade union rights in Canada. The cases decided that there is no constitutional protection for the legal right to strike, but did not set out the limits of constitutional protection for union rights. This paper examines several decisions from superior courts and courts of appeal since the trilogy, (particularly a 1988 decision of the Court of Appeal for the Northwest Territories) and discusses the availability of Charter protection for other trade union interests, including organizing and certification rights. It is argued that there are several grounds for testing standard Canadian collective bargaining legislation under the Charier. Assuming that a prima facie breach of the Charter can be established, the paper examines a sample of collective bargaining statutory provisions in accordance with the principles established by the courts for the application of s. 1 of the Charter, concluding that some, but not all, of such provisions would survive a vigorous application of the Charter.