bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of an Epidemiological Anomaly of COVID-19: Transcultural and Immunological Psychiatry
Authors: Pandarakalam James , Pandarakalam James
Published: February 2021

Evidence exists for an epidemiological trend of transmission concentrations of COVID-19 within migrant
communities from tropical weather conditions. Minority groups are over-represented in hospitalisations and
deaths from the virus, and it appears that the observed anomaly may be due to multifactorial causes.
Underactive immune responses in cooler temperatures and diminished synthesis of vitamin D, both of which
are associated with genetic factors among ethnic minority groups, could help to explain the higher incidence
of COVID-19 among ethnic minority communities. Neither factor is specific to a migrant community but
common to general populations. The overstatement of contributory genetic factors runs the risk of racial
stigmatisation. If environmental factors are given their due importance, individuals belonging to ethnic
minorities may try to adopt new ways to combat the pandemic, while overemphasising racial factors would
only leave them helpless. The renewed interest of psychiatrists in immunology would support the emerging
field of immunopsychiatry. COVID-19 is environmentally sensitive, and all medical specialities, including
the mental health profession, should contribute their wisdom to defeating or making a truce with the viral
phenomenon.
Falando com um pedaço de pau: a potência comunicativa do boneco popular
Authors: De Castro Kely Elias
Published: February 2021

O Teatro de Bonecos Popular do Nordeste brasileiro resiste bravamente, com seus mestres, saberes populares e tradições culturais, apesar de tantas contrariedades impostas. Neste artigo, discorre-se sobre como isto se dá, considerando aspectos históricos e de inovação que a linguagem obteve. Para tanto, utiliza-se bibliografia específica de Teatro de Animação, ampara-se em pesquisas de campo e relato de experiência artística da autora.
DEVELOPMENT OF DOMESTIC MARKET LOGISTICS IN THE CONTEXT OF VALUE CHAIN THEORY
Authors: LISYUK VM , BUYUKLI-TARAN TP
Published: February 2021

Topicality. At the statistic of the introduction of advanced market logic, as an economic system, which can be seen, as a part (pidsystem) of the national economy, as well as the improvement of the market of goods and services, as well as the delivery of self-service Shown the place of logic in the economic system of the market type, zokrem, in the economy of Ukraine. We will also be aware of the current economic problems that occur on the background of �Covid-2019�. The relevance of our dosl�dzhen polyag is in the fact that the stench is straightforward to the acceleration of the development of the national economy with a clearly defined strategy of the fake development, as it is, but it is infused with the occasionally rimmed theoretical concrete and realities.
Aim and tasks. Apparently, the meta of the information described in the statistics of the fields described in terms of methods and mechanisms injected into the organization of the logistics of commodity markets for the efficiency of their functions was suggested.
To reach the end of the day, you need to check the following:
- clarify the structure of the market of the same warehouse elements of the logistic lancers with the storage of the pre-Slidnitsky apparatus of the foreign theory of systems;
- propose the classification of logistic lancers of commodity markets according to the principles of their approval;
- to show the practical storage of theoretical visnovk�v on a specific market, the cream of the market of milk and dairy products.
Research results and conclusion. The statty is well-placed, there are a number of problems, there are hypotheses and postulates.
1.It is important that the role of structural logistic statements is made, and the logistic system of the market, logistic lancer, lanka, service is very important. The significance of the role of logic in the system of market organization of the national economic system and the prelude to the development of the national economy.
2. The classification of logistic lants of commodity markets has been broken down and the values of these types are based on proprietary signs: method of approval, form of function, method of organizing, organizer of organizing, participants
3. Consider the role of logic, as the formation of the organization of the market, the seedling, and the logistic system and the market of the national economy and the specific market of milk and dairy products.
Dampak Program Pengembangan Pelatihan terhadap Kinerja Perawat RSIJ Cempaka Putih dengan Model Pendekatan System Dynamics
Authors: Hartono Budi , Afriza Nisa
Published: February 2021

This study aims to see how much the nurse development program of the Jakarta Cempaka Putih Islamic Hospital has the potential to influence the performance of nurses at the Cempaka Putih Islamic Hospital. The research method used in this research is to use the Dynamic System Approach (System Dynamics). The results of modeling using historical data show that the training development program in the long term shows a decrease so that it has an impact on the performance of nurses which also shows decreased behavior while the results of modeling based on simulations show a significant increase in nurse performance if an increase in the policy target hours of the nurse training development program is based on target hours from HPMI. In conclusion, the performance of nurses at RSIJ Cempaka Putih actually shows decreased behavior, which is different from the performance reported based on the Key Performance Indicator (KPI) and Performance Appraisal that the dominant nurse's performance is up to standard.

Keywords: Performance, Competence, Training Motivation, System Dynamics
Pengalaman dan Gangguan Aktivitas Seksualitas Klien Penyakit Jantung Koroner
Authors: Amin Muhammad , Fredrika Larra , Kartika Delvi Duwi
Published: February 2021

This study aims to determine how the experience of sexual activity disorders in clients with coronary heart disease in Dr. M. Yunus Bengkulu. This type of research used in this research is qualitative, with the phenomenological method. This study resulted in four (4) themes, namely: aspects of knowledge about coronary heart disease, aspects of treatment, aspects of sexual activity disorders in clients with coronary heart disease, emotional aspects. The results showed that sexual activity disorders in coronary heart patients were lack of appetite, stimulation, orgasm, and dyspareunia. In conclusion, the client's efforts to reduce pain and improve when having a husband and wife is by using lubricants.

 

Keywords: Coronary Heart, Experience, Sexuality
Kualitas Tidur Berhubungan dengan Perubahan Tekanan Darah pada Lansia
Authors: J Harsismanto , Andri Juli , Payana Tirta Dwi , Andrianto Muhammad Bagus , Sartika Andry
Published: February 2021

The purpose of this study was to determine the relationship of sleep quality with changes in blood pressure in elderly hypertension at Tresna Werdha Social Home (PSTW) Bengkulu Province. This type of research is quantitative research in the form of an analytic survey with a cross-sectional research design. Univariate analysis results showed blood pressure in hypertensive elderly at Tresna Werdha Social Home (PSTW), which is 12 respondents (54.5%) had mild hypertension, ten respondents (45.5%) had moderate hypertension. Sleep quality experienced by elderly hypertension, 11 respondents (50%) experienced good sleep quality, and 11 other respondents (50%) experienced poor sleep quality. The results of bivariate analysis using chi-square test obtained ρ value = 0,000 and C value = 0.674. In conclusion, there is a significant relationship between sleep quality and changes in blood pressure in hypertensive elderly at Tresna Werdha Social Home (PSTW) in 2019. Poor sleep quality affects changes in elderly blood pressure.

 

Keywords: Sleep Quality, Elderly, Blood Pressure
Pendidikan Kesehatan tentang Menstruasi terhadap Kesiapan dalam Menghadapi Menarche pada Siswi Kelas V dan VI
Authors: Delima Mera , Andriani Yessi , Lestari Tri
Published: February 2021

This study aims to determine health education's effect on menstruation on readiness to face menarche in grade V and VI students at SDN 39 Kinali in 2019. The research method is pre-experimental quantitative research with a one-group pretest-posttest design. The results of this study are the readiness of respondents to face menarche before being given health education is 91.50, after being given health education is 101.25 the mean difference between the respondent's willingness to meet menarche before and after health education with statistical test results obtained in P = 0.001 with a difference in mean Average 9750. In conclusion, health education has an effect on menstruation on students' readiness to face menarche.

Keywords: Menarche, Menstruation, Health Education
Pemberian Pendidikan Kesehatan Melalui Telenursing terhadap Peningkatan Pengetahuan dan Pencegahan Keputihan Patologis pada Remaja
Authors: Andriani Yessi , Maidaliza Maidaliza , Alvaensi Rinona Iverta
Published: February 2021

The purpose of this study was to determine the effect of providing health education through telenursing on increasing knowledge and prevention of pathological vaginal discharge in adolescents at SMK Negeri 2 Bukittinggi in 2020. This study used a quasy experimental method with a group pre-post test design. The results showed an increase in the mean level of knowledge and prevention of leucorrhoea, where the mean level of knowledge before and after health education was 12.77 and 27.18, while the mean prevention of vaginal discharge before and after health education was 18.55 and 33.82. The statistical test results obtained a p-value of 0.000 for the level of knowledge and a p-value of 0.000 for the prevention of pathological leucorrhoea. In conclusion, there is an effect of providing health education through telenursing on increasing knowledge and preventing pathological vaginal discharge.

 

Keywords: Leucorrhoea, Health Education, Telenursing
Peran Consumer Awareness dan Perception terhadap Buying Interest pada Properti Syariah
Authors: Safitri Fuji , Sunarya Erry , Danial R. Deni Muhammad
Published: February 2021

The purpose of this study is to study the interaction of consumer awareness and perception of buying interests. The method in this study uses non propbability sampling, namely convenience sampling by distributing questionnaires to prospective sharia property buyers. The analysis technique used is multiple linear regression analysis, and for hypothesis testing is a statistical test simultaneously (F test). F test results show a sig value of 0,000 <0,05 which means that together Consumer Awareness (X1) and Perception (X2) have a significant effect on Buying Interests (Y). Based on the test of the coefficient of determination of 0.749 can be interpreted according to the contribution given Consumer awareness and Perception of Buying Interest is 74.9%, then by 25.1% can be changed by other variables that are not necessary in this study.

Keywords : Consumer Awareness, Perception  dan Buying Interest
Kekuatan Keunikan Produk dan Word Of Mouth terhadap Keputusan Pembelian
Authors: Permana Ibnu Agung , M. Ramdan Asep , Mulia Z Faizal
Published: February 2021

The purpose of this study was to determine the uniqueness of the product and word of mouth towards purchasing decisions at the UMKM UMKM Sukugumi Sugema UMKM. The research method used by the authors in this study used a system of random sampling where the authors distributed questionnaires to 75 consumers. The analysis technique used by the writer is using multiple linear regression analysis techniques, multiple correlation coefficient and determination coefficient. And to test the hypothesis the author uses a partial statistical test (t test) and a simultaneous test (f test). The results of the study using the determination coefficient test shows the value (Adjuster R2) of 0.749 which means the influence of product uniqueness and word of mouth on purchasing decisions is 76% and 24% influenced by other factors not examined. In addition, testing multiple correlation coefficients shows an R value of 0.869, which means there is a strong relationship between product uniqueness and word of mouth towards purchasing decisions. Based on the results of the F test that has been done, the sig value is found. 0,000 <0,05. Conclusions, product uniqueness and word of mouth partially have a significant effect on purchasing decisions.

Keywords: Product Uniqueness, Word Of Mouth, Purchasing Decision.
Analisis Kinerja Keuangan Sebelum dan Sesudah Right Issue
Authors: Anisa Rini , Samsudin Acep , Jhoansyah Dicky
Published: February 2021

This Research was meant to analyze the differences in the company's financial performance before and after the rights issue for companies on the IDX for the period 2015-2016. The financial performance measurement method uses the analysis of the wicoxon signed rank test which uses several financial ratios from several components. In the income statement and balance sheet, namely Current Ratio (CR), Debt to equity ratio (DER), Total asset turnover (TATO), Return on equity (ROE). Sampling in this study using purposive sampling method, the sample in this study amounted to 15 companies on the IDX that carried out rights issues for the period 2015-2016. The results of this study indicate that there are significant differences in the ratio of CR, DER and TATO two years before and two years after the rights issue, while in the ROE ratio there are no significant differences two years before and two years after the rights issue. This result shows that the company's financial performance two years before and two years after the rights issue is more efficient in increasing short-term and long-term debt and in utilizing the company's sales assets to increase.

Keywords: Right Issue, Current Ratio, Work Analysis
PENGENDALIAN PERSEDIAAN BAHAN BAKU DALAM PROSES PRODUKSI DENGAN MENGGUNAKAN METODE ECONOMIC ORDER QUANTITY (EOQ)
Authors: Rahayu R Elia , Norisanti Nor , Samsudin Acep
Published: February 2021

The purpose of this study is to control the supply of raw materials using the Economic Order Quantity (EOQ) method in Tahu Nugraha Jaya Sukabumi UKM. The data analysis method used is quantitative descriptive to describe and describe the data to be examined and then processed using EOQ. This study uses the EOQ method to determine the total inventory cost. The data needed in this study are the number of purchases of raw materials, the amount of use of raw materials, storage costs, and ordering costs. The results of this study indicate that by applying the EOQ method can further optimize the supply of raw materials by minimizing raw materials with increased inventory. With the application of the Economic Order Quantity (EOQ) method it shows more efficient than conventional methods of the company. Conclusions, seen from the difference in the TIC of the two methods, the more efficient method is the Economic Order Quantity (EOQ) method that is equal to 244,392.94 while the calculation used by the company is 374,325. so that it can be obtained that there is a difference between the Company TIC and the EIC method TIC.

Keywords: Raw Material Inventory, Production Process
Kinerja Keuangan Menggunakan Metode Economic Value Added (EVA) dan Market Value Added (MVA)
Authors: Wulandari Puspita , Samsudin Acep , Norisanti Nor
Published: February 2021

Tujuan penelitian ini adalah untuk mengukur kinerja keuangan perusahaan pada PT. Hero Supermaket Tbk periode 2013-2017 dengan menggunakan Economic Value Added (EVA) dan Market Value Added (MVA). Penelitian ini menggunakan metode deskriftif kuantitatif. Sumber data yang digunakan pada penelitian ini adalah data keuangan perusahaan PT. Hero Supermarket Tbk periode 2013-2017. Hasil penelitian ini menunjukkan bahwa terdapat nilai tambah pada PT. Hero Supermarket Tbk pada tahun 2017, dan tidak adanya nilai tambah pada tahun 2013-2016 dengan menggunakan metode EVA. Kemudian pada metode MVA, PT. Hero Supermarket menunjukkan adanya nilai tambah. Simpulan, angka EVA PT. Hero Supermarket Tbk pada tahun 2013 sampai dengan tahun 2016 menunjukkan bahwa perusahaan tidak mampu menciptakan nilai tambah karena nilai EVA yang dihasilkan adalah negatif. Pada tahun 2017 terdapat nilai tambah. Nilai Market Value Added (MVA) pada tahun 2013-2017 bernilai positif yang menujukkan bahwa perusahaan telah berhasil menciptakan kekayaan pada pemegang saham walaupun dari tahun ke tahun megalami penurunan karena harga saham yang menurun.

Kata Kunci: EVA, Kinerja Keuangan, MVA
Peran Job Insecurity dan Job Satisfaction terhadap Komitmen Organisasi
Authors: Nurleni Siti , Sunarya Erry , Z. Faizal Mulia
Published: February 2021

Tujuan dari penelitian ini adalah untuk mengukur peran job insecurity dan job satisfaction terhadap komitmen organisasi karyawan pada PT. Doosan Jaya 3 Kabupaten Sukabumi. Metode yang digunakan dalam penelitian ini adalah metode deskriptif dan asosiatif. Pengambilan sampel dalam penelitian ini menggunakan simple random sampling yang termasuk dalam propotional sampling dengan menyebarkan 100 kuesioner kepada karyawan bagian produksi PT. Doosan Jaya 3 di Kabupaten Sukabumi. Hasil penelitian ini menunjukkan bahwa uji simultan job insecurity dan job satisfaction memperoleh signifikansi sebesar 0,000 (<0,05) dan nilai Fhitung sebesar 251,457 (>Ftabel = 2,36). Simpulan, job insecurity dan job satisfaction berpengaruh positif dan signifikan terhadap komitmen organisasi.

Kata Kunci: Job Insecurity, Job Satisfaction, Komitmen Organisasi
GAMBARAN AKTIVITAS FISIK, STATUS GIZI DAN TEKANAN DARAH REMAJA BINAAN DINAS SOSIAL PALU TAHUN 2018
Authors: Melisa Abbas  , Diantamaela Mayalisa , Nila Ardila Arif
Published: February 2021

Pola makan dan akivitas fisik yang tidak seimbang merupakan faktor penyebab obesitas dan hipertensi. Saat ini pola konsumsi gizi pada remaja lebih banyak ditentukan dari lingkungan pergaulan. Sementara aktivitas yang dilakukan sangat kurang, sehingga beresiko tinggi untuk memiliki status gizi lebih. Angka kejadian aktivitas fisik pada remaja di Indonesia yang kurang aktif masih cukup tinggi,begitupun tekanan darah tinggi dan obesitas di Sulawesi tengah juga masih cukup tinggi. Penelitian inibertujuan untuk mengetahui gambaran aktivitas fisik, status gizi dan tekanan darah remaja binaan DinasSosial Palu tahun 2018. Metode penelitian adalah deskriptif terhadap 30 anak remaja binaan Dinas Sosial Palu 2018. Data diperoleh melalui pengisian kuesioner dan pemeriksaan yang diisi pada case report . Dilakukan analisis distribusi frekuensi menggunakan program SPSS 21. Hasil penelitian: (1) aktivitas fisikterbanyak yaitu tidak aktif (76,7 %), kurang aktif (23,3 %), aktif (0,0 %). (2) kategori status gizi yangterbanyak yaitu gizi normal (56,7 %), gizi kurang (23,3 %), gizi lebih (20,0 %), (3) kategori tekanan darah yang terbanyak normotensi (93,3 %), prehipertensi (6,7 %). Remaja binaan dinas sosial palu, sebagian besar berstatus gizi normal, tetapi mereka mempunyai aktivitas fisik yang rendah. Temuan gizi kurang masih cukup besar. Tidak ditemukan remaja yang obesitas maupun hipertensi.
HUBUNGAN ANTARA FAKTOR-FAKTOR RESIKO CEREBRO-KARDIOVASKULER DENGAN KEJADIAN VERTIGO DI RSU ANUTAPURA PALU TAHUN 2018
Authors: Inri Hardyanti  , Halim Wijoyo , Muchtar Masita
Published: February 2021

Vertigo merupakan keluhan tersering di unit gawat darurat dengan etiologi sederhana maupunkompleks yang sering overlapping. Angka kejadian vertigo setiap tahunnya mengalami peningkatan.Vertigo dapat menjadi keluhan utama ataupun satu-satunya pada pasien strok ataupun jantung koroner.Gangguan cerebro-kardiovaskuler juga diperkirakan terjadi pada 3-4% pasien vertigo. Deteksi danpengobatan awal sangat dibutuhkan untuk pencegahan disabilitas dan kematian. Pasien vertigo memilikiresiko lebih besar terkena strok dan jantung koroner karena beberapa fakotor resiko yaitu hipertensi,diabetes mellitus, dan dislipidemia, sehingga harus dilakukan pemeriksaan neurologis yang komprehensif,survei terhadap faktor resiko, dan follow up secara regular selama beberapa tahun setelah menerimapengobatan vertigo. Penelitian ini bertujuan untuk mengetahui hubungan antara hipertensi, diabetesmelitus, dan dislipidemia dengan kejadian vertigo. Metode penelitian ini bersifat analitik observasionaldengan design case control study pengambilan sampel dilakukan secara consecutive sampling.Pengumpulan data faktor risiko dilakukan dengan cara wawancara menggunakan kuesioner dan casereport pada kedua kelompok pasien. Dilakukan uji Chi-Squar pada batas kemaknaan α=5% melaluiprogram SPSS. Hasil penelitian menunjukkan Kejadian vertigo berhubungan dengan hipertensi(p=0,018; OR 4,753), dengan diabetes mellitus (p=0,020; OR 3,032). Belum dapat dibuktikan hubunganyang bermakna dengan dislipidemia (p=0,844; OR 0,655). Sehingga dapat disimpulkan bahwa adahubungan kejadian vertigo dengan hipertensi dan diabetes mellitus di RSU Anutapura Palu Tahun 2018
PENGARUH ADVERSITY QUOTIENT DAN KOMPETENSI TERHADAP KINERJA KARYAWAN PT. ASKES (PERSERO) PALU
Authors: Salim Firza Umar
Published: February 2021

Penelitian ini bertujuan untuk mengetahui apakah variabel adversity quotient dan kompetensi secara serempak berpengaruh signifikan terhadap kinerja karyawan PT. Askes (Persero) Palu, pengaruh variabel adversity quotient terhadap kinerja karyawan PT. Askes (Persero) Palu dan pengaruh variabel kompetensi terhadap kinerja karyawan PT. Askes (Persero) Palu. Populasi dalam penelitian ini berjumlah 54 karyawan. Penarikan sampel menggunakan rumus Slovin sehingga hasil yang diperoleh sejumlah 35 responden. Hasil penelitian menunjukkan bahwa: hasil perhitungan diperoleh F sig pada taraf nyata ά = 0,05 maka diperoleh Sig F (0.000) < 0,05. Dengan demikian dapat dinyatakan bahwa secara bersama-sama (serempak) variabel bebas mempunyai pengaruh yang signifikan terhadap variabel tidak bebasnya; adversity quotient berpengaruh signifikan terhadap kinerja dengan nilai sig 0.000; dan kompetensi berpengaruh signifikan terhadap kinerja dengan nilai sig 0.000. Hubungan kedua variabel adversity quotient dan kompetensi yang diamati dalam penelitian ini terhadap kinerja karyawan PT. Askes (Persero) Palu sebesar 88,5%. Adapun kelebihannya sebesar 11,5% diakibatkan oleh variabel lain di luar variabel bebas yang diamati, diantaranya kepemimpinan, kompensasi dll.

 

Kata Kunci: Adversity Quotient, Kompetensi, Kinerja.
An Improved Set-based Reasoner for the Description Logic 𝒟ℒD4,×†
Authors: Cantone Domenico , Nicolosi-Asmundo Marianna , Santamaria Daniele Francesco
Published: February 2021

We present a KE-tableau-based implementation of a reasoner for a decidable fragment of (stratified) set theory expressing the description logic 𝒟ℒ〈4LQSR,×〉(D) (𝒟ℒD4,×, for short). Our application solves the main TBox and ABox reasoning problems for 𝒟ℒD4,×. In particular, it solves the consistency and the classification problems for 𝒟ℒD4,×-knowledge bases represented in set-theoretic terms, and a generalization of the Conjunctive Query Answering problem in which conjunctive queries with variables of three sorts are admitted. The reasoner, which extends and improves a previous version, is implemented in C++. It supports 𝒟ℒD4,×-knowledge bases serialized in the OWL/XML format and it admits also rules expressed in SWRL (Semantic Web Rule Language).
TAR DNA-Binding Protein 43 Is Associated with Rate of Memory, Functional and Global Cognitive Decline in the Decade Prior to Death
Authors: Buciuc Marina , Tosakulwong Nirubol , Machulda Mary M. , Whitwell Jennifer L. , Weigand Stephen D. , Murray Melissa E. , Reichard R. Ross , Parisi Joseph E. , Dickson Dennis W. , Boeve Bradley F. , Knopman David S. , Petersen Ronald C. , Josephs Keith A.
Published: February 2021

Background: Transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with memory impairment and overall cognitive decline. It is unclear how TDP-43 contributes to the rate of clinical decline. Objective: To determine whether cross-sectional and longitudinal cognitive and functional decline are associated with anatomical distribution of TDP-43 in the brain. Methods: Longitudinal clinical-neuropathologic autopsy cohort study of 385 initially cognitively normal/mildly impaired older adults prospectively followed until death. We investigated how TDP-43, amyloid-β (Aβ), tau neurofibrillary tangles (NFT), Lewy body disease (LBD), age, sex, and genetics are associated with clinical scores and rates of their longitudinal decline. Results: Of 385 participants, 260 (68%) had no TDP-43, 32 (8%) had TDP-43 limited to amygdala, and 93 (24%) had TDP-43 in the hippocampus and beyond. Higher TDP-43 and Braak NFT stages independently were associated with faster decline in global cognition, functional performance measured by Clinical Dementia Rating scale, and naming and episodic memory, whereas older age was associated with slower rate of cognitive, psychiatric, and functional decline. Cross-sectionally the following associations were found: higher TDP-43 and Braak NFT - worse performance; higher Aβ burden - worse global cognition, more behavioral changes, the latter also with higher LBD; older age - worse naming, lower frequency of behavioral changes; female sex - more impaired naming and better preserved episodic memory. There were no genetic associations. Conclusion: The association of TDP-43 distribution with decline in cognitive and functional performance suggests that TDP-43 is playing a role in the clinical progression to dementia. Further characterization of clinical features associated with TDP-43 can facilitate establishment of antemortem diagnosis.
The Economic Burden of Alzheimer’s Disease in Zhejiang Province
Authors: Yu Enyan , Liao Zhengluan , Fan Weixing , Hu Weiming , Tian Guoqiang , Chen Ke , Chen Sunke , Hua Haoshui , Zheng Hong , Fang Xiangming , Li Guorong , Xie Jian , Wu Shaochang
Published: February 2021

Background: The World Alzheimer Report has described and predicted the economic burden of Alzheimer’s disease (AD) patients in detail for four consecutive years. There was a large-scale national survey in China launched by Professor Jianping Jia in 2015, but it did not adequately represent the average economic burden of AD patients in Zhejiang Province. Objective: To investigate the economic burden and main factors influencing Alzheimer’s disease (AD) in Zhejiang Province. Methods: We recruited 830 patients from 10 cities in Zhejiang Province, evaluated their per capita and total cost related to AD treatment and care in 2017, and analyzed the main factors affecting economic burden from the perspective of demographic characteristics and disease severity. Results: In 2017, per capita cost of AD was 114,343.7 yuan, while the total cost was 27.53 billion yuan, accounting for 0.77% of Zhejiang Province’s GDP (5176.8 billion yuan). Total cost, direct medical cost, and indirect cost have different correlations with age, education level, type of work, marital status, comorbidity, and disease severity. Conclusion: The economic burden of AD in Zhejiang Province is heavy, similar to the national burden, and interventions based on demographic characteristics and disease severity can help reduce it.
Brain Metabolism and Microglia Activation in Mild Cognitive Impairment: A Combined [18F]FDG and [11C]-(R)-PK11195 PET Study
Authors: Tondo Giacomo , Boccalini Cecilia , Caminiti Silvia Paola , Presotto Luca , Filippi Massimo , Magnani Giuseppe , Frisoni Giovanni Battista , Iannaccone Sandro , Perani Daniela
Published: February 2021

Background: Mild cognitive impairment (MCI) is a transitional condition between normal cognition and dementia. [18F]FDG-PET reveals brain hypometabolism patterns reflecting neuronal/synaptic dysfunction, already in the prodromal MCI phase. Activated microglia is part of the pathogenetic processes leading to neurodegeneration. Objective: Using [11C]-(R)-PK11195 and [18F]FDG-PET, we aimed to in vivo investigate the presence of microglial activation, and the relationship with brain glucose metabolism, in single MCI subjects. Methods: Eight MCI subjects underwent both [18F]FDG-PET and [11C]-(R)-PK11195 PET. We used validated quantification methods to obtain brain hypometabolism maps and microglia activation peaks in single subjects. We investigated both the spatial overlap and the relationship between brain glucose hypometabolism and microglia activation, by means of Dice similarity coefficient and using Pearson’s correlation at single subject level. Results: Each MCI showed a specific brain hypometabolism pattern indicative of different possible etiologies, as expected in MCI population (i.e., Alzheimer’s disease-like, frontotemporal dementia-like, hippocampal-type, normal aging type). [11C]-(R)-PK11195 PET analysis revealed a spatial concordance with regional hypometabolism in all subjects with several clusters of significant microglia activation showing an inverse correlation with the regional metabolism. This was proportional to the strength of between-signals correlation coefficient (β  =  –0.804; p = 0.016). Conclusion: Microglia activation is present in the prodromal MCI phase of different underlying etiologies, showing spatial concordance and inverse correlation with brain glucose metabolism at single-subject level. These findings suggest a possible contribution of activated microglia to neurodegeneration, showing important implications for local immune activity in the early neurodegenerative processes.
Hyperconnectivity of Self-Referential Network as a Predictive Biomarker of the Progression of Alzheimer’s Disease
Authors: Yao Weina ,   Alzheimer’s Disease Neuroimaging Initiative, Chen Haifeng , Luo Caimei , Sheng Xiaoning , Zhao Hui , Xu Yun , Bai Feng
Published: February 2021

Background: Self-referential processing is associated with the progression of Alzheimer’s disease (AD), and cerebrospinal fluid (CSF) proteins have become accepted biomarkers of AD. Objective: Our objective in this study was to focus on the relationships between the self-referential network (SRN) and CSF pathology in AD-spectrum patients. Methods: A total of 80 participants, including 20 cognitively normal, 20 early mild cognitive impairment (EMCI), 20 late MCI (LMCI), and 20 AD, were recruited for this study. Independent component analysis was used to explore the topological SRN patterns, and the abnormalities of this network were identified at different stages of AD. Finally, CSF pathological characteristics (i.e., CSF Aβ, t-tau, and p-tau) that affected the abnormalities of the SRN were further determined during the progression of AD. Results: Compared to cognitively normal subjects, AD-spectrum patients (i.e., EMCI, LMCI, and AD) showed a reversing trend toward an association between CSF pathological markers and the abnormal SRN occurring during the progression of AD. However, a certain disease state (i.e., the present LMCI) with a low concentration of CSF tau could evoke more hyperconnectivity of the SRN than other patients with progressively increasing concentrations of CSF tau (i.e., EMCI and AD), and this fluctuation of CSF tau was more sensitive to the hyperconnectivity of the SRN than the dynamic changes of CSF Aβ. Conclusion: The integrity of the SRN was closely associated with CSF pathological characteristics, and these findings support the view that the hyperconnectivity of the SRN will play an important role in monitoring the progression of the pre-dementia state to AD.
The Impact of Long Working Hours on Cognitive Function: A Follow-Up Study with Gender Stratification1
Authors: Lee Seunghyun , Choi Joon Yul , Lee Wanhyung
Published: February 2021

Background: Recent studies have shown that long working hours can have adverse consequences on health and possibly trigger biological processes that mediate the relationship between long working hours and cognitive decline. Objective: To investigate whether long working hours and the overall duration such exposure is associated with a decline in cognitive function. Methods: Data obtained during the Korean Longitudinal Study on Aging (n = 2,518) during the period 2006–2018 were used to explore the relationship between long working hours and cognitive decline. Korean version of the Mini-Mental State Examination (K-MMSE) scores were used to evaluate cognitive function. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), which were used to evaluate declines in K-MMSE scores over the 12-year study period. Results: Overall HR (95% CI) for a decline in cognitive function in long working hours group was 1.13 (0.73–1.17). When categorized by sex, women with long working hours had an HR (95% CI) of 1.50 (1.05–2.22), K-MMSE scores decreased significantly after working long hours for 5 years (p < 0.01). Conclusion: The study furthers understanding of the effects of long working hours on cognitive decline among female workers. Further research is required to determine the effects of long working hours on cognitive functions.
Fault detection in mixture production process based on wavelet packet and support vector machine
Authors: Chen Yan , song Huan-sheng , yang Yan-ni , wang Gang-feng
Published: February 2021

Mixture production equipment is widely employed in road construction, and the quality of the produced mixture is the essential factor to ensure the quality of road construction. To detect the quality of the real-time produced mixture and solve the shortcomings of laboratory detection lag, a new fault detection method in the mixture production process is proposed, which is based on wavelet packet decomposition (WPD) and support vector machine (SVM). The proposed scheme includes feature extraction, feature selection, SVM classification, and optimization algorithm. During feature extraction, wavelet basis function is utilized to 4-layer decompose the aggregate and asphalt data mixed in real-time. The energy value calculated by wavelet packet coefficient is the extracted feature. During feature selection, a method combining the chi-square test and wrapper (CSW) is conducted to select the optimal feature subset from WPD features. Eventually, by adopting the optimal feature subset, SVM has been developed to classify various faults. Its parameters are optimized by differential evolution (DE) algorithm. In the test stage, multiple faults of different specifications of aggregates and asphalt are detected in the mixture production process. The results demonstrate that (1) accuracy produced by the CSW method with WPD features is 4.33% higher than the PCA method with statistical features; (2) SVM classification method optimized by DE algorithm brings an increase in recognition accuracy of identifying different types of mixture production faults produced by different equipment. Compared to other available methods, the proposed algorithm has a very outstanding detection performance.
A framework for meaningful use of clinical decision model: A diabetic nephropathy prediction modeling based on real world data
Authors: Jiang Kui , Shang Yujuan , Wang Lei , Zhang Zheqing , Zhou Siwei , Dong Jiancheng , Wu Huiqun
Published: February 2021

This study aims to propose a framework for developing a sharable predictive model of diabetic nephropathy (DN) to improve the clinical efficiency of automatic DN detection in data intensive clinical scenario. Different classifiers have been developed for early detection, while the heterogeneity of data makes meaningful use of such developed models difficult. Decision tree (DT) and random forest (RF) were adopted as training classifiers in de-identified electronic medical record dataset from 6,745 patients with diabetes. After model construction, the obtained classification rules from classifier were coded in a standard PMML file. A total of 39 clinical features from 2159 labeled patients were included as risk factors in DN prediction after data preprocessing. The mean testing accuracy of the DT classifier was 0.8, which was consistent to that of the RF classifier (0.823). The DT classifier was choose to recode as a set of operable rules in PMML file that could be transferred and shared, which indicates the proposed framework of constructing a sharable prediction model via PMML is feasible and will promote the interoperability of trained classifiers among different institutions, thus achieving meaningful use of clinical decision making. This study will be applied to multiple sites to further verify feasibility.
PD-L1 Expression and Treatment Implications in Metastatic Clear Cell Renal Cell Carcinoma: A Systematic Review
Authors: Jang Albert , Sweeney Patrick L. , Barata Pedro C. , Koshkin Vadim S.
Published: February 2021

BACKGROUND:

Over the past decade, immune checkpoint inhibitors (ICIs) have increasingly become the standard of care for various advanced malignancies, including metastatic clear cell renal cell carcinoma (mccRCC). Most ICIs currently used in clinical practice inhibit the interaction between the programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) complex. A deeper understanding of this interaction and PD-L1 expression in tumors has led to more effective therapies in the treatment of advanced cancers, but the debate regarding the utility of PD-L1 as a biomarker continues.

OBJECTIVE:

We aimed to systematically evaluate the role of PD-L1 in mccRCC in terms of expression and treatment implications.

METHODS:

Following PRISMA guidelines, we performed a systematic literature search using PubMed and Embase through August 31, 2020. Titles and abstracts were screened to identify articles for full-text review. A hand search was also performed using Google Scholar and the bibliography to relevant studies.

RESULTS:

A total of 26 articles were identified, and relevant data were extracted and organized. The available information regarding PD-L1 expression in mccRCC from both prospective clinical trials and retrospective studies were summarized. We discussed the utility of PD-L1 as a predictive and prognostic biomarker in mccRCC, its association with other potential biomarkers, and the pattern and level of expression of PD-L1 in primary versus metastatic tumors.

CONCLUSIONS:

Although significant progress has been made, much more remains to be learned regarding the differences between PD-L1+ and PD-L1- ccRCC tumors, in terms of both the underlying biology and clinical responses to immunotherapy and other agents.
Factors affecting the intention of purchasing the smartwatch of Nha Trang Consumers by using extended theory of planned behavior
Authors: Nguyen Nga Thi
Published: February 2021

The main aims of this study is to explore the intention to use smart watches from consumers perspective. The study applied the extended theory of planned behavior by integrating two additional variables including: aesthetic design and perceived price in addition to variables in the original intended behavior theory model, specifically: attitudes towards smartwatch purchases, perceived behavioral control and social norms to explain consumers' intent to buy smartwatches in Nha Trang city. This study adopts partial least squares structural equation modeling (PLS-SEM) technique to test the reliability and validity of the measures based on a sample of 200 consumers in Nha Trang. The results indicate that five proposed hypotheses are supported by data with an increasing degree of impact, which are perceived behavioral control (ß = 0.58), attitudes towards smartwatch purchases (ß = 0.20), aesthetic design (ß = 0.15), perceived price (ß = 0.14) and social norms (ß = 0.11). The research results are expected to make significant contributions both in academic research and practical research through useful and practical recommendations for watch product consumption.
Applying Bayesian method to investigate determinants of non performing loans of banks in Vietnam
Authors: Pham Nam Hai , Tan Nguyen Ngoc
Published: February 2021

This study was conducted to determine the factors affecting non-performing loans of commercial banks in Vietnam for the period 2007 - 2018. The study applies the Bayesian approach and the Random-walk Metropolis-Hastings algorithm to evaluate the impact of micro and macro factors on non-performing loans of commercial banks. The dependent variable is non-performing loans, which is measured by the ratio of non-performing loans divided by total outstanding loans; the independent variables in terms of bank characteristics are non-performing loans of the previous year, profitability, bank size, bak loans, and bank capital; the macro variables are inflation and GDP growth. Research data was collected from financial statements of 30 Vietnamese commercial banks and the General Statistics Office of Vietnam from 2007 to 2018. To increase the reliability and efficiency of the model as well as reasonable Bayes inference, a convergence test of the MCMC chain was performed. The result of this study shows that non-performing loans of the previous year, bank size, bank loan, bank capital, and inflation have positive impacts on bank non-performing loans. In addition, bank profitability and GDP growth rate are factors that have the opposite effects. Based on the research results, the author proposes policy implications for the decision-makers to help banks reduce non-performing loans and promote banks to operate effectively and more efficiently.
PREVALENCE OF LEIOMYOSARCOMA OF UTERUS: A THREE YEAR RETROSPECTIVE STUDY
Authors: Sarswat Saket , Soni D. P. , Soni Saurabh , . Vimlesh , Fatima Qadir
Published: February 2021

Background: leiomyosarcoma of uterus are notorious for their aggressive nature and poor prognosis. The relative rarity of uterine leiomyosarcomas, as well as their pathological diversity, hinders studies aimed at improving understanding of the disease and makes it difficult to define the optimum management.

Methods: This retrospective study is conducted over a period of three year from January 2017 to December 2020. All the hysterectomy specimens received at the Department of Pathology were processed and included in the study during the study period. We report here the Prevalence of leiomyosarcoma of uterus at Bikaner region.

Results: We received a total of 952 hysterectomy specimens at Department of Pathology during the study period. Out of which 546 were operated and sent with the clinical diagnosis of uterine fibroid. Two patients were diagnosed with histopathological features of leiomyosarcoma which is 0.37% of all uterine fibroids and 0.21% of all hysterectomies at Bikaner region.

Conclusion: Uterine leiomyosarcomas are rare but highly malignant tumors which are difficult to diagnose preoperatively and mostly mimic clinical features of benign uterine fibroids. The leiomyosarcomas show poor prognosis. This makes it important to investigate uterine malignancies histopathologically to rule out leiomyosarcomas so that appropriate treatment can be started early.

Keywords: Uterine leiomyosarcoma, uterine fibroid.
Implementasi Blended learning untuk Meningkatkan Efektivitas Pembelajaran Online berbasis Classroom Mata Kuliah Profesi Keguruan pada Semester II di STIT Raden Wijaya Mojokerto Tahun Akademik 2019/2020
Authors: Padi Achmad
Published: February 2021

The formation of the Blended learning concept is due to an understanding of combining the power of face-to-face learning with online learning. This opens the possibility for a redesign that goes beyond enhancing the traditional classroom lecture. Blended learning represents a new approach and a combination of face-to-face learning with online learning activities that are consistent with specific program objectives. The problems that can be summarized by the author based on a survey in July 2020 to 45 students who are in the second semester class include; a total of 28% of students have not mastered the google classroom platform implemented by the STIT Raden Wijaya campus, 85.6% have difficulty understanding the learning materials delivered by the lecturers, 71.6% of students stated that there were many assignments and were burdened with deadlines for submitting assignments, and 82.7 % of students want face-to-face learning. Based on the focus of the study, this study aims to determine the increase in the effectiveness of classroom-based online learning through the implementation of blended learning for Teaching Professional Courses in Semester II at STIT Raden Wijaya Mojokerto for the 2019/2020 Academic Year. This research uses quantitative methods. This type of research is an experimental research. The subjects of this study were students of the even semester of the 2019/2020 academic year in the Islamic Education Study Program of STIT Raden Wijaya Mojokerto. The population of this study were second semester students (class 2019), with saturated sampling totaling 46 students consisting of 2 classes. Namely the experimental class 23 and the control class 23. The results of the study that have been discussed, it can be concluded that learning using blended learning is better than students who only use online learning. These results are proven by the results of the Independent Sample t-test, it is known that the average learning rate with blended learning is 56.00 greater than online learning which is 51.96. The analysis must go through two stages, namely the F test and the t test. It is known that F is 3,668 with a probability of 0.62, because 0.62> 0.05, it can be concluded that the two variants are the same or identical. t test post test results with Equal variances assumed (assuming the two variants are the same) is -3,748 with a probability of 0.001, because 0.001 <0.05; It can be concluded that on average, blended learning is different from online learning
Superior advance research in the electro-discharge machining of Ti alloys: Review
Authors: Ali Mahdavinejad Ramezan , Asghari Ilani Mohsen
Published: February 2021

Electro Discharge Machining (EDM) known as an advanced machining process that much used for machining material with any hardness and complexity geometry in a high level of the accuracy in the cases of demand of the industrial application. The conception of the EDM process is included in applying electro-thermal energy in the gap, by discharge electrical power on the breaking point of the dielectric without any contact between electrodes. Due to the existing ability for removing debris from the surface, there is a lot of metallurgy defect on it. To improve and optimize EDM performance, the machine’s operating parameters, Input, during& output parameters, need to be optimized. Another handy way to reform of the view metallurgical must take picture sub-structure from the initial and subsequent layer. At the end for catching special status, adjust the technical parameters with metallurgical defects. Studies in case of the EDM have indicated that the appropriate selection of the way to control of the process, material, and operating parameters had considerably improved the process performance and also causing to was better the quality machined surface. This paper made a comprehensive review of the research studies in a different section of the EDM of various grades of titanium and its alloys. This review presents the simulation, experimental and theoretical studies on EDM that helped to improve the process performance, including material removal rate, surface quality, and tool wear rate, the stability of process among others. However, here are collected most of the research are done surrounding of EDM of Ti alloys as the developments of EDM and are seen material for future.
Símbolos de la Enfermera (o)
Authors: De Enfermería Escuela
Published: February 2021

Símbolos de la Enfermera (o)
Quienes Somos y que Hacemos las Enfermeras/os
Authors: Benavides Germaniaa
Published: February 2021

Quienes Somos y que Hacemos las Enfermeras/os
que la Comunidad Piensa
Authors: De Enfermería Escuela
Published: February 2021

Lo que la Comunidad Piensa
Síndrome de Aspiración Meconial
Authors: Chancusig P. Luis E. , Tobar L. Wilson C.
Published: February 2021

Síndrome de Aspiración Meconial
Primera Promoción 2008 - 2011
Authors: De Enfermería Escuela
Published: February 2021

Primera Promoción 2008 - 2011