bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Osteopontin in Psoriasis—A Scoping Review
Authors: Kimak Agnieszka , Woźniacka Anna
Published: January 2024

Psoriasis is a chronic systemic disease with an immunological basis and a complex pathophysiology. The chronic inflammatory status of psoriasis is associated with several comorbidities, such as metabolic syndrome, obesity, and cardiovascular disease. The development of psoriasis is influenced by osteopontin, a glycoprotein that influences physiological and pathological reactions by modulating Th1 and Th17 cellular responses, stimulating keratinocyte proliferation, regulating cellular apoptosis, and promoting angiogenesis. The recent identification of immune pathways involved in psoriasis development has facilitated the development of biological treatments; however, a better understanding of the intricate relationship between underlying inflammatory processes, psoriasis development, and accompanying comorbidities is needed for improved disease management.
Comprehensive Investigation of Hardness, Wear and Frictional Force in Powder Metallurgy Engineered Ti-6Al-4V-SiCp Metal Matrix Composites
Authors: Hegde Adithya , Nayak Rajesh , Bolar Gururaj , Shetty Raviraj , Ranjan Rakesh , Naik Nithesh
Published: January 2024

Metal matrix composites (MMCs) have achieved significant attention in engineering applications because of their exceptional properties, like increased strength-to-weight ratiosand resistance to wear. However, their manufacturing processes pose challenges for industries, such as oxidation, porosity, and chemical reactions. To address these challenges, this study investigates the processing and sintering (500 °C) of Ti-6Al-4V-SiCp composites and their mechanical properties, particularly hardness, wear and frictional force using a statistical approach. The main objective of this research is to identify optimal processing conditions for Ti-6Al-4V-SiCp composites that yield maximum hardness, minimal wear and frictional force. Thisstudy varies three key parameters, namely compaction pressure (Ton/sq.inch), SiC (wt.%), and PVA binder (wt.%) using Taguchi’s design of experiments (TDOE). Further, the response surface methodology (RSM) is used to develop second-order models to predict the output values under different processing conditions, by correlating with the values obtained from TDOE. The results indicate that the most significant influence on the output is exerted by SiC (wt.%), followed by PVA binder (wt.%) and compaction pressure (Ton/sq.inch). To achieve higher hardness with minimal wear and frictional force during processing, SiCp (15 wt.%), compaction pressure (4 Ton/sq.inch), and PVA binder (3 wt.%) arerecommended. Finally, microstructural analysis using (SEM) scanning electron microscope images, optical macrographs and (AFM) atomic force microscopy revealed that the inclusion of 15 wt.% SiCp resulted in improved hardness, wear and frictional force compared to 20 wt.% SiCp. In conclusion, this study provides valuable insights into optimizing the processing parameters of Ti-6Al-4V-SiCp samples, enabling the production of materials with enhanced hardness and wear resistance.
Design of Type-IV Composite Pressure Vessel Based on Comparative Analysis of Numerical Methods for Modeling Type-III Vessels
Authors: Bouhala Lyazid , Koutsawa Yao , Karatrantos Argyrios , Bayreuther Claus
Published: January 2024

Compressed gas storage of hydrogen has emerged as the preferred choice for fuel cell vehicle manufacturers, as well as for various applications, like road transport and aviation. However, designers face increasing challenges in designing safe and efficient composite overwrapped pressure vessels (COPVs) for hydrogen storage. One challenge lies in the development of precise software programs that consider a multitude of factors associated with the filament winding process. These factors include layer thickness, stacking sequence, and the development of particularly robust models for the dome region. Another challenge is the formulation of predictive behavior and failure models to ensure that COPVs have optimal structural integrity. The present study offers an exploration of numerical methods used in modeling COPVs, aiming to enhance our understanding of their performance characteristics. The methods examined include finite element analysis in Abaqus, involving conventional shell element, continuum shell element, three-dimensional solid element, and homogenization techniques for multilayered composite pressure vessels. Through rigorous comparisons with type-III pressure vessels from the literature, the research highlights the most suitable choice for simulating COPVs and their practicality. Finally, we propose a new design for type-IV hydrogen composite pressure vessels using one explored method, paving the way for future developments in this critical field.
Engineering Degradation Rate of Polyphosphazene-Based Layer-by-Layer Polymer Coatings
Authors: Brito Jordan , Moon Junho , Hlushko Raman , Aliakseyeu Aliaksei , Andrianov Alexander K. , Sukhishvili Svetlana A.
Published: January 2024

Degradable layer-by-layer (LbL) polymeric coatings have distinct advantages over traditional biomedical coatings due to their precision of assembly, versatile inclusion of bioactive molecules, and conformality to the complex architectures of implantable devices. However, controlling the degradation rate while achieving biocompatibility has remained a challenge. This work employs polyphosphazenes as promising candidates for film assembly due to their inherent biocompatibility, tunability of chemical composition, and the buffering capability of degradation products. The degradation of pyrrolidone-functionalized polyphosphazenes was monitored in solution, complexes and LbL coatings (with tannic acid), providing the first to our knowledge comparison of solution-state degradation to solid-state LbL degradation. In all cases, the rate of degradation accelerated in acidic conditions. Importantly, the tunability of the degradation rate of polyphosphazene-based LbL films was achieved by varying film assembly conditions. Specifically, by slightly increasing the ionization of tannic acid (near neutral pH), we introduce electrostatic “defects” to the hydrogen-bonded pairs that accelerate film degradation. Finally, we show that replacing the pyrrolidone side group with a carboxylic acid moiety greatly reduces the degradation rate of the LbL coatings. In practical applications, these coatings have the versatility to serve as biocompatible platforms for various biomedical applications and controlled release systems.
Editorial for the Special Issue on “Geometry Reconstruction from Images”
Authors: Meneveaux Daniel , Cherchi Gianmarco
Published: January 2024

This special issue on geometry reconstruction from images has received much attention from the community, with 10 published papers [...]
Clinical Impact of Comprehensive Molecular Profiling in Adolescents and Young Adults with Sarcoma
Authors: Andrew Eden C. , Lewin Jeremy , Desai Jayesh , Orme Lisa , Hamilton Anne , Bae Susie , Zhu Wenying , Nicolson Shannon , Varghese Leila N. , Mitchell Camilla B. , Vissers Joseph H. A. , Xu Huiling , Grimmond Sean M. , Fox Stephen B. , Luen Stephen J.
Published: January 2024

Sarcomas are a heterogenous group of tumours that commonly carry poor prognosis with limited therapeutic options. Adolescents and young adults (AYAs) with sarcoma are a unique and understudied patient population that have only achieved modest survival gains compared to other groups. We present our institutional experience of AYAs with sarcoma who underwent comprehensive molecular profiling (CMP) via either large-panel targeted DNA sequencing or whole genome and transcriptome sequencing and evaluated the feasibility and clinical impact of this approach. Genomic variants detected were determined to be clinically relevant and actionable following evaluation by the Molecular Tumour Board. Clinicians provided feedback regarding the utility of testing three months after reporting. Twenty-five patients who were recruited for CMP are included in this analysis. The median time from consent to final molecular report was 45 days (interquartile range: 37–57). Potentially actionable variants were detected for 14 patients (56%), and new treatment recommendations were identified for 12 patients (48%). Pathogenic germline variants were identified in three patients (12%), and one patient had a change in diagnosis. The implementation of CMP for AYAs with sarcoma is clinically valuable, feasible, and should be increasingly integrated into routine clinical practice as technologies and turnaround times continue to improve.
Advances in the Study of Common and Rare CFTR Complex Alleles Using Intestinal Organoids
Authors: Krasnova Maria , Efremova Anna , Mokrousova Diana , Bukharova Tatiana , Kashirskaya Nataliya , Kutsev Sergey , Kondratyeva Elena , Goldshtein Dmitry
Published: January 2024

Complex alleles (CAs) arise when two or more nucleotide variants are present on a single allele. CAs of the CFTR gene complicate the cystic fibrosis diagnosis process, classification of pathogenic variants, and determination of the clinical picture of the disease and increase the need for additional studies to determine their pathogenicity and modulatory effect in response to targeted therapy. For several different populations around the world, characteristic CAs of the CFTR gene have been discovered, although in general the prevalence and pathogenicity of CAs have not been sufficiently studied. This review presents examples of using intestinal organoid models for assessments of the two most common and two rare CFTR CAs in individuals with cystic fibrosis in Russia.
Visible Vowels as a Tool for the Study of Language Transfer
Authors: Heeringa Wilbert , Velde Hans Van de
Published: January 2024

In this paper, we demonstrate the use of Visible Vowels to detect formant and durational differences between L2 and L1 speakers. We used a dataset that contains vowel measures from L1 speakers of French and from L2 learners of French, with Italian, Spanish and English as L1. We found that vowels that are not part of the L1 phonological system are often pronounced differently by L2 speakers. Inspired by the Native Language Magnet Theory which was introduced by Patricia Kuhl in 2000, we introduced magnet plots that relate vowels shared by the French phonological system and the learners’ phonological system—the magnet vowels—to the vowels found only in the French phonological system. At a glance, it can be seen which vowels are attracted to the magnets and which vowels become further away from the magnets. When comparing vowel spaces, we found that the shape of the French vowel space of the English learners differed most from the shape of L1 speakers’ vowel space. Finally, it was found that the vowel durations of the L2 speakers are greater than that of the L1 speakers of French, especially those of the English learners of French.
Pregnant Patients with COVID-19 Admitted to an ICU: A Comparison with a Historical Cohort of Critical Pregnant Patients without COVID-19
Authors: Iacovazzo Carmine , Capasso Letizia , Visani Carola , Salomè Serena , Vargas Maria
Published: January 2024

Aim of the study: Maternal mortality and ICU admissions have increased during the COVID-19 pandemic. We reported a case-series of pregnant patients with COVID-19 admitted to an ICU and we compared them with a historical cohort of pregnant patients admitted to an ICU without COVID-19. Methods: We included all pregnant patients with laboratory-confirmed COVID-19 infection admitted to our ICU in 2021. As a historical control group, we included all pregnant women who were admitted to our ICU between 1 January 2008 and 31 December 2013. Results: In 2021, 11 pregnant patients (pts) with COVID-19 were admitted to an ICU, representing 2.87% of ICU admissions. We found that pregnant patients with COVID-19 (1) had a higher BMI (34.6 vs. 28.8, p = 0.04) and a lower gestational age (30.6 vs. 34 weeks, p = 0.03), (2) were mainly admitted for respiratory failure (100% vs. 2.7%; p = 0.001) and (3) required more days of invasive and non-invasive ventilations (54.5% vs. 5.2%, p = 0.002), a longer duration of stay at the ICU (21.9 vs. 4.8 days, p < 0.0001) and had a higher mortality rate (27.3% vs. 0%, p = 0.0192). Conclusions: Pregnant patients with COVID-19 represent a challenge for ICU physicians due to their different characteristics and outcomes when compared to pregnant patients without COVID-19.
Changes in Corrosion Behaviour of Zinc and Aluminium Coatings with Increasing Seawater Acidification
Authors: Senderowski Cezary , Rejmer Wojciech , Vigilianska Nataliia , Jeznach Arkadiusz
Published: January 2024

The increase in greenhouse gas emissions has led to seawater acidification, increasing the corrosion rate of metal structures in marine applications. This paper indicates that the spraying of four types of coatings, namely Zn, Al, Zn-Al, and Al-Mg, using the arc-spraying technique on steel substrate S235JR, creates effective protective coatings that interact differently with various pH solutions exposed to varying levels of seawater acidification. The study analyses the structural properties of the coating materials using SEM and XRD techniques. Electrochemical parameters are evaluated in solutions with different pH and salinity levels. The results demonstrate that alloy metallic coatings provide excellent resistance to corrosion in low-pH solutions.
Determining the Effects of Inter-Layer Time Interval in Powder-Fed Laser-Directed Energy Deposition on the Microstructure of Inconel 718 via In Situ Thermal Monitoring
Authors: Handler Evan , Yadollahi Aref , Liu Yucheng , Thompson Scott M.
Published: January 2024

Cylindrical Inconel 718 specimens were fabricated via a blown-powder, laser-directed energy deposition (DED-L) additive manufacturing (AM) process equipped with a dual thermal monitoring system to learn key process–structure relationships. Thermographic inspection of the heat affected zone (HAZ) and melt pool was performed with different layer-to-layer time intervals of ~0 s, 5 s, and 10 s, using an infrared camera and dual-wavelength pyrometer, respectively. Maximum melt pool temperatures were found to increase with layer number within a substrate affected zone (SAZ), and then asymptotically decrease. As the layer-to-layer time interval increased the HAZ temperature responses became more repetitive, indicating a desirable approach for achieving a more homogeneous microstructure along the height of a part. Microstructural variations in grain size and the coexistence of specific precipitate phases and Laves phases persisted among the investigated samples despite the employed standard heat treatment. This indicates that the effectiveness of any post DED-L heat treatment depends significantly on the initial, as-printed microstructure. Overall, this study demonstrates the importance of part size, part number per build, and time intervals on DED-L process parameter selection and post-process heat treatments for achieving better quality control.
Microstructural Evolution in a 6060 Extrudable Al-Alloy: Integrated Modeling and Experimental Validation
Authors: Aristeidakis John S. , Haidemenopoulos Gregory N. , Bjørge Ruben , Marioara Calin D. , Kamoutsi Helen , Giarmas Evangelos , Rafailidis Nikolaos
Published: January 2024

Desirable properties including strength, ductility and extrudability of 6060 Al-alloys are highly dependent on processing to control the development of microstructural features. In this study, the process chain of an extrudable 6060 Al-alloy was modeled in an Integrated Computational Materials Engineering framework and validated experimentally via quantitative SEM-EDX and TEM. All critical processing stages were considered including casting, homogenization heating and holding, extrusion cooling and two-stage aging. Segregation and intermetallics formation were accurately predicted and experimentally verified in the as-cast condition. Diffusion simulations predicted the dissolution of intermetallics and completion of β-AlFeSi to α-AlFeSi transformation during homogenization, in excellent agreement with quantitative SEM-EDX characterization. Precipitation simulations predicted the development of a β″ strengthening dispersion during extrusion cooling and aging. Needle-shaped β″ precipitates were observed and analyzed with quantitative high-resolution TEM, validating predictions. Ensuing precipitation strengthening was modeled in terms of aging time, presenting good agreement with yield strength measurements. Precipitate-Free Zones and coarse, metastable β-type particles on dispersoids and grain boundaries were investigated. The proposed integrated modeling and characterization approach considers all critical processing stages and could be used to optimize processing of extrudable 6xxx Al-alloys, providing insight to mechanisms controlling microstructural evolution and resulting properties.
A Computational Approach to Individual Cell-Based Decision Algorithms Involved in Bone Remodeling
Authors: Serrano-Antón Belén , Mian Chloë , Fuente Rocío , Bertocchini Federica , Herrero Miguel A. , López José M. , Oleaga Gerardo E. , Arias Clemente F.
Published: January 2024

This work is concerned with bone remodeling, an intriguing and efficient biological process that ensures the optimal compliance of the human skeleton by screening and replacing any single piece of it on a recursive basis. We propose here that a class of algorithms, which are simple enough to be implemented at an individual cell level, suffices to account for the two main features of such homeostatic process: thorough screening of the whole skeleton on the one hand and destruction and subsequent replacement of any single bone piece on the other. This last process is accomplished at a microscopic scale by special groups of cells, assembled for that purpose, called Bone Multicellular Units (BMUs). Moreover, it is shown that the algorithms proposed are robust, i.e, they remain functional in a wide range of biomechanical environments, thus allowing for different remodeling rates at different places.
Neonatal Birthweight Spectrum: Maternal Risk Factors and Pregnancy Outcomes in Saudi Arabia
Authors: Wahabi Hayfaa , Elmorshedy Hala , Amer Yasser S. , Saeed Elshazaly , Razak Abdul , Hamama Ibrahim Abdelaziz , Hadid Adnan , Ahmed Samia , Aleban Sarah A. , Aldawish Reema Abdullah , Alyahiwi Lara Sabri , Alnafisah Haya Abdullah , AlSubki Raghad E. , Albahli Norah Khalid , Almutairi Aljohara Ayed , Alsanad Layan Fahad , Fayed Amel
Published: January 2024

Background and Objectives: Low-birth-weight (LBW) neonates are at increased risk of morbidity and mortality which are inversely proportional to birth weight, while macrosomic babies are at risk of birth injuries and other related complications. Many maternal risk factors were associated with the extremes of birthweight. The objectives of this study are to investigate maternal risk factors for low and high birthweight and to report on the neonatal complications associated with abnormal birth weights. Materials and Methods: We conducted a retrospective analysis of medical records of deliveries ≥ 23 weeks. We classified the included participants according to birth weight into normal birth weight (NBW), LBW, very LBW (VLBW), and macrosomia. The following maternal risk factors were included, mother’s age, parity, maternal body mass index (BMI), maternal diabetes, and hypertension. The neonatal outcomes were APGAR scores < 7, admission to neonatal intensive care unit (NICU), respiratory distress (RD), and hyperbilirubinemia. Data were analyzed using SAS Studio, multivariable logistic regression analyses were used to investigate the independent effect of maternal risk factors on birthweight categories and results were reported as an adjusted odds ratio (aOR) and 95% Confidence Interval (CI). Results: A total of 1855 were included in the study. There were 1638 neonates (88.3%) with NBW, 153 (8.2%) with LBW, 27 (1.5%) with VLBW, and 37 (2.0%) with macrosomia. LBW was associated with maternal hypertension (aOR = 3.5, 95% CI = 1.62–7.63), while increasing gestational age was less likely associated with LBW (aOR = 0.51, 95% CI = 0.46–0.57). Macrosomia was associated with maternal diabetes (aOR = 3.75, 95% CI = 1.67–8.41), in addition to maternal obesity (aOR = 3.18, 95% CI = 1.24–8.14). The odds of VLBW were reduced significantly with increasing gestational age (aOR = 0.41, 95% CI = 0.32–0.53). In total, 81.5% of VLBW neonates were admitted to the NICU, compared to 47.7% of LBW and 21.6% of those with macrosomia. RD was diagnosed in 59.3% of VLBW neonates, in 23% of LBW, in 2.7% of macrosomic and in 3% of normal-weight neonates. Hyperbilirubinemia was reported in 37.04%, 34.21%, 22.26%, and 18.92% of VLBW, LBW, NBW, and macrosomic newborns, respectively. Conclusions: Most neonates in this study had normal birthweights. Maternal hypertension and lower gestational age were associated with increased risk of LBW. Additionally, maternal obesity and diabetes increased the risk of macrosomia. Neonatal complications were predominantly concentrated in the LBW and VLBW, with a rising gradient as birthweight decreased. The main complications included respiratory distress and NICU admissions.
Microvascular Capillary and Precapillary Cardiovascular Disturbances Strongly Interact to Severely Affect Tissue Perfusion and Mitochondrial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Evolving from the Post COVID-19 Syndrome
Authors: Wirth Klaus Josef , Löhn Matthias
Published: January 2024

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID-19 Syndrome (PCS). A fraction of the PCS patients develop the full clinical picture of ME/CFS. New observations in microvessels and blood from patients suffering from PCS have appeared and include microclots and malformed pathological blood cells. Capillary blood flow is impaired not only by pathological blood components but also by prothrombotic changes in the vascular wall, endothelial dysfunction, and the expression of adhesion molecules in the capillaries. These disturbances can finally cause a low capillary flow and even capillary stasis. A low cardiac stroke volume due to hypovolemia and the inability of the capacitance vessels to adequately constrict to deliver the necessary cardiac preload generate an unfavorable low precapillary perfusion pressure. Furthermore, a predominance of vasoconstrictor over vasodilator influences exists, in which sympathetic hyperactivity and endothelial dysfunction play a strong role, causing the constriction of resistance vessels and of precapillary sphincters, which leads to a fall in capillary pressure behind the sphincters. The interaction of these two precapillary cardiovascular mechanisms causing a low capillary perfusion pressure is hemodynamically highly unfavorable in the presence of a primary capillary stasis, which is already caused by the pathological blood components and their interaction with the capillary wall, to severely impair organ perfusion. The detrimental coincidence of microcirculatory and precapillary cardiovascular disturbances may constitute the key disturbance of the Post-COVID-19 syndrome and finally lead to ME/CFS in predisposed patients because the interaction causes a particular kind of perfusion disturbance—capillary ischemia/reperfusion—which has a high potential of causing mitochondrial dysfunction by inducing sodium- and calcium-overload in skeletal muscles. The latter, in turn, worsens the vascular situation through the generation of reactive oxygen species to close a vicious cycle from which the patient can hardly escape.
Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy
Authors: Chen Guan-Yu , Kuo Kung-Kai , Chuang Shih-Chang , Tseng Kuang-Yi , Wang Shen-Nien , Chang Wen-Tsan , Cheng Kuang-I
Published: January 2024

Background and Objectives: Optimal opioid analgesia is an excellent analgesia that does not present unexpected adverse effects. Nalbuphine, acting on the opioid receptor as a partial mu antagonist and kappa agonist, is considered a suitable option for patients undergoing laparoscopic surgery. Therefore, we aim to investigate the appropriate dosage of nalbuphine for post-operative pain management in patients with laparoscopic cholecystectomy. Materials and Methods: Patients were randomly categorized into low, medium, and high nalbuphine groups. In each group, a patient control device for post-operative pain control was programed with a low (0.05 mg/kg), medium (0.10 mg/kg), or high (0.20 mg/kg) nalbuphine dose as a loading dose and each bolus dose with a lockout interval of 7 min and without background infusion. Primary and secondary outcomes included the post-operative pain scale and nalbuphine consumption, and episodes of post-operative opioid-related adverse events and satisfactory scores. Results: The low-dosage group presented a higher initial self-reported pain score in comparison to the other two groups for the two hours post-op (p = 0.039) but presented lower nalbuphine consumption than the other two groups for four hours post-op (p = 0.047). There was no significant difference in the analysis of the satisfactory score and adverse events. Conclusions: An appropriate administration of nalbuphine could be 0.1 to 0.2 mg/kg at the initial four hours; this formula could be modified to a lower dosage (0.05 mg/kg) in the post-operative management of laparoscopic cholecystectomy.
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Authors: Zorkina Yana , Ushakova Valeria , Ochneva Aleksandra , Tsurina Anna , Abramova Olga , Savenkova Valeria , Goncharova Anna , Alekseenko Irina , Morozova Irina , Riabinina Daria , Kostyuk Georgy , Morozova Anna
Published: January 2024

Lipids are a crucial component of the human brain, serving important structural and functional roles. They are involved in cell function, myelination of neuronal projections, neurotransmission, neural plasticity, energy metabolism, and neuroinflammation. Despite their significance, the role of lipids in the development of mental disorders has not been well understood. This review focused on the potential use of lipids as blood biomarkers for common mental illnesses, such as major depressive disorder, anxiety disorders, bipolar disorder, and schizophrenia. This review also discussed the impact of commonly used psychiatric medications, such as neuroleptics and antidepressants, on lipid metabolism. The obtained data suggested that lipid biomarkers could be useful for diagnosing psychiatric diseases, but further research is needed to better understand the associations between blood lipids and mental disorders and to identify specific biomarker combinations for each disease.
Novel Wild-Type Pediococcus and Lactiplantibacillus Strains as Probiotic Candidates to Manage Obesity-Associated Insulin Resistance
Authors: Somalou Paraskevi , Ieronymaki Eleftheria , Feidaki Kyriaki , Prapa Ioanna , Stylianopoulou Electra , Spyridopoulou Katerina , Skavdis George , Grigoriou Maria E. , Panas Panayiotis , Argiriou Anagnostis , Tsatsanis Christos , Kourkoutas Yiannis
Published: January 2024

As the food and pharmaceutical industry is continuously seeking new probiotic strains with unique health properties, the aim of the present study was to determine the impact of short-term dietary intervention with novel wild-type strains, isolated from various sources, on high-fat diet (HFD)-induced insulin resistance. Initially, the strains were evaluated in vitro for their ability to survive in simulated gastrointestinal (GI) conditions, for adhesion to Caco-2 cells, for bile salt hydrolase secretion, for cholesterol-lowering and cellular cholesterol-binding ability, and for growth inhibition of food-borne pathogens. In addition, safety criteria were assessed, including hemolytic activity and susceptibility to antibiotics. The in vivo test on insulin resistance showed that mice receiving the HFD supplemented with Pediococcus acidilactici SK (isolated from human feces) or P. acidilactici OLS3-1 strain (isolated from olive fruit) exhibited significantly improved insulin resistance compared to HFD-fed mice or to the normal diet (ND)-fed group.
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Authors: Maftei Nicoleta-Maricica , Raileanu Cosmin Raducu , Balta Alexia Anastasia , Ambrose Lenuta , Boev Monica , Marin Denisa Batîr , Lisa Elena Lacramioara
Published: January 2024

Probiotics, known to be live microorganisms, have been shown to improve or restore the gut microbiota, which in turn has been linked to improved health. It is believed that probiotics are the modern equivalent of a panacea, with claims that they may treat or prevent different diseases both in children and adults (e.g., from colic in babies to cardiovascular disease, respiratory infection, and cancer in adults). Ever since the early 2000s, probiotic-based fermented foods have had a resurgence in popularity, mostly due to claims made regarding their health benefits. Fermented foods have been associated with the prevention of irritable bowel syndrome, lactose intolerance, gastroenteritis, and obesity, but also other conditions such as chronic diarrhea, allergies, dermatitis, and bacterial and viral infections, all of which are closely related to an unhealthy lifestyle. Recent and ongoing developments in microbiome/microbiota science have given us new research directions for probiotics. The new types, mechanisms, and applications studied so far, and those currently under study, have a great potential to change scientific understanding of probiotics’ nutritional applications and human health care. The expansion of fields related to the study of the microbiome and the involvement of probiotics in its improvement foreshadow an era of significant changes. An expanding range of candidate probiotic species is emerging that can address newly elucidated data-driven microbial niches and host targets. In the probiotic field, new variants of microbiome-modulating interventions are being developed, including prebiotics, symbiotics, postbiotics, microbial consortia, live biotherapeutic products, and genetically modified organisms, with renewed interest in polyphenols, fibers, and fermented foods to ensure human health. This manuscript aims to analyze recent, emerging, and anticipated trends in probiotics (sources, doses, mechanism of action, diseases for which probiotics are administered, side effects, and risks) and create a vision for the development of related areas of influence in the field.
Water Speciation and Storage Capacity of Olivine under the Reduced Fluid—Peridotite Interaction
Authors: Kupriyanov Igor N. , Sokol Alexander G. , Kruk Alexey N.
Published: January 2024

The key features of the interaction between peridotites of the continental lithospheric mantle and reduced hydrocarbon-rich fluids have been studied in experiments conducted at 5.5 GPa and 1200 °C. Under this interaction, the original harzburgite undergoes recrystallization while the composition of the fluid changes from CH4-H2O to H2O-rich with a small amount of CO2. The oxygen fugacity in the experiments varied from the iron-wustite (IW) to enstatite-magnesite-olivine-graphite/diamond (EMOG) buffers. Olivines recrystallized in the interaction between harzburgite and a fluid generated by the decomposition of stearic acid contain inclusions composed of graphite and methane with traces of ethane and hydrogen. The water content of such olivines slightly exceeds that of the original harzburgite. Redox metasomatism, which involves the oxidation of hydrocarbons in the fluid by reaction with magnesite-bearing peridotite, leads to the appearance of additional OH absorption bands in the infrared spectra of olivines. The water content of olivine in this case increases by approximately two times, reaching 160–180 wt. ppm. When hydrocarbons are oxidized by interaction with hematite-bearing peridotite, olivine captures Ca-Mg-Fe carbonates, which are products of carbonate melt quenching. This oxidative metasomatism is characterized by the appearance of specific OH absorption bands and a significant increase in the total water content in olivine of up to 500–600 wt. ppm. These findings contribute to the development of criteria for reconstructing metasomatic transformations in mantle rocks based on the infrared spectra and water content of olivines.
Theoretical Investigation of a Coumarin Fluorescent Probe for Distinguishing the Detection of Small-Molecule Biothiols
Authors: Deng Yue , Huang He , Feng Jian , Peng Yongjin , Liu Yuling
Published: January 2024

Monitoring the level of biothiols in organisms would be beneficial for health inspections. Recently, 3-(2′-nitro vinyl)-4-phenylselenyl coumarin as a fluorescent probe for distinguishing the detection of the small-molecule biothiols cysteine/homocysteine (Cys/Hcy) and glutathione (GSH) was developed. By introducing 4-phenyselenium as the active site, the probe CouSeNO2/CouSNO2 was capable of detecting Cys/Hcy and GSH in dual fluorescence channels. Theoretical insights into the fluorescence sensing mechanism of the probe were provided in this work. The details of the electron excitation process in the probe and sensing products under optical excitation and the fluorescent character were analyzed using the quantum mechanical method. All these theoretical results would provide insight and pave the way for the molecular design of fluorescent probes for the detection of biothiols.
Assessing Phytogenic and Chemogenic Silver Nanoparticles for Antibacterial Activity and Expedited Wound Recuperation
Authors: Ahmad Bilal , Chang Li , Yin Caiyun , Wu Zhou , Tong Aidi , Tong Chunyi , Liu Bin
Published: January 2024

Green silver nanoparticles (AgNPs) possess tremendous promise for diverse applications due to their versatile characteristics. Coriander and other plant extracts have become popular for greenly synthesizing AgNPs as an economical, biocompatible, cost-effective, and environmentally beneficial alternative to chemical processes. In this study, we synthesized AgNPs from coriander leaves and evaluated their antibacterial, anti-inflammatory, antioxidant, and wound-healing acceleration properties in comparison to chemically synthesized AgNPs. The zeta potentials of AgNPs extracted from green and chemical processes were −32.4 mV and −23.4 mV, respectively. TEM images showed a cuboidal shape of green and chemical AgNPs with a diameter of approximately 100 nm. The FTIR spectra of green AgNPs showed an extreme absorption peak at 3401 cm−1, which signifies O-H stretching vibrations, typically linked to hydroxyl groups. In vitro results elaborated that AgNPs from coriander exerted a stronger effect on anti-Klebsiella pneumoniae (KP) through interrupting cell integrity, generating ROS, depleting ATP, and exhibiting significant antioxidant activity, compared with AgNPs synthesized chemically. In vivo experiments showed that AgNPs from coriander, as opposed to chemically manufactured AgNPs, greatly accelerated the healing of wounds contaminated with Klebsiella pneumoniae bacteria by effectively eliminating the bacteria on the wounds and stimulating skin regeneration and the deposition of dense collagen. In vivo assays further demonstrated that green AgNPs effectively enhanced Klebsiella pneumoniae-infected wound healing by extenuating local inflammatory responses and up-regulating VEGF and CD31 expression. In conclusion, green AgNPs significantly alleviated the inflammation without significantly harming the organism.
Boosting Crop Growth Rates of Hybrid Rice (Pukhraj) through Synergistic Use of Organic Nitrogen Sources in Conjunction with Urea Nitrogen
Authors: Amanullah  , Ullah Hidayat
Published: January 2024

In Northwestern Pakistan’s rice-based cropping systems, the prevalent reliance on inorganic nitrogen fertilizers (INF) has led to insufficient nitrogen (N) contributions from soil organic manures (OM). This study aims to evaluate the impact of organic sources (OS), including animal manures (AM) and crop residues (CR), on crop growth rates (CGR) in a rice-wheat rotation. A two-year field experiment involving hybrid rice (Oryza sativa L., Pukhraj) was conducted in Batkhela, Khyber Pakhtunkhwa. Various OS and inorganic-N (urea) combinations were applied, emphasizing their influence on CGR. The findings highlight poultry manure (PM) application as the most impactful on CGR, while wheat straw (WS) application resulted in the lowest CGR among the six OS investigated. Additionally, the use of AM showcased superior CGR compared to CR. In the initial year, the highest CGR occurred, with 75% of N sourced from urea and 25% from OS. In the second year, a balanced 50% N application from each source yielded the highest CGR. Urea and PM demonstrated the most robust CGR among OS combinations, while urea and WS yielded the lowest. Notably, onion leaves, a cost-effective option, delivered promising results comparable to berseem residues, indicating their potential as organic manure, especially in sulfur-deficient soils. These findings underscore the viability of onion residue management as a cost-effective alternative to ammonium sulfate fertilizers with global applicability. The abstract recommends promoting organic sources, particularly poultry manure and onion leaves, alongside inorganic-N fertilizers to enhance CGR and reduce dependence on costly alternatives. However, further research and field trials are necessary to explore the long-term impacts of these organic sources on soil health, nutrient cycling, and the sustainability of rice-based cropping systems in Northwestern Pakistan and beyond. In conclusion, this study investigates the influence of organic sources on CGR in rice-wheat rotations, emphasizing the superiority of poultry manure and onion leaves. The findings highlight cost-effective alternatives to conventional fertilizers, emphasizing the need for further research to validate long-term sustainability and applicability beyond the study area.
The Roles and Interactions of Porphyromonas gingivalis and Fusobacterium nucleatum in Oral and Gastrointestinal Carcinogenesis: A Narrative Review
Authors: Wang Bing , Deng Juan , Donati Valentina , Merali Nabeel , Frampton Adam E. , Giovannetti Elisa , Deng Dongmei
Published: January 2024

Epidemiological studies have spotlighted the intricate relationship between individual oral bacteria and tumor occurrence. Porphyromonas gingivalis and Fusobacteria nucleatum, which are known periodontal pathogens, have emerged as extensively studied participants with potential pathogenic abilities in carcinogenesis. However, the complex dynamics arising from interactions between these two pathogens were less addressed. This narrative review aims to summarize the current knowledge on the prevalence and mechanism implications of P. gingivalis and F. nucleatum in the carcinogenesis of oral squamous cell carcinoma (OSCC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC). In particular, it explores the clinical and experimental evidence on the interplay between P. gingivalis and F. nucleatum in affecting oral and gastrointestinal carcinogenesis. P. gingivalis and F. nucleatum, which are recognized as keystone or bridging bacteria, were identified in multiple clinical studies simultaneously. The prevalence of both bacteria species correlated with cancer development progression, emphasizing the potential impact of the collaboration. Regrettably, there was insufficient experimental evidence to demonstrate the synergistic function. We further propose a hypothesis to elucidate the underlying mechanisms, offering a promising avenue for future research in this dynamic and evolving field.
The Assessment of Infection Risk in Patients with Vitiligo Undergoing Dialysis for End-Stage Renal Disease: A Retrospective Cohort Study
Authors: Shah Pearl , Hanson Mitchell , Waller Jennifer L. , Tran Sarah , Baer Stephanie L. , Taskar Varsha , Bollag Wendy B.
Published: January 2024

Vitiligo is an autoimmune condition that causes patchy skin depigmentation. Although the mechanism by which vitiligo induces immunocompromise is unclear, other related autoimmune diseases are known to predispose those affected to infection. Individuals with vitiligo exhibit epidermal barrier disruption, which could potentially increase their susceptibility to systemic infections; patients with renal disease also show a predisposition to infection. Nevertheless, there is little research addressing the risk of infection in dialysis patients with vitiligo in comparison to those without it. A retrospective analysis was performed on patients with end-stage renal disease (ESRD) in the United States Renal Data System who started dialysis between 2004 and 2019 to determine if ESRD patients with vitiligo are at an increased risk of bacteremia, cellulitis, conjunctivitis, herpes zoster, or septicemia. Multivariable logistic regression modeling indicated that female sex, black compared to white race, Hispanic ethnicity, hepatitis C infection, and tobacco use were associated with an enhanced risk of vitiligo, whereas increasing age and catheter, versus arteriovenous fistula, and access type were associated with a decreased risk. After controlling for demographics and clinical covariates, vitiligo was found to be significantly associated with an increased risk of bacteremia, cellulitis, and herpes zoster but not with conjunctivitis and septicemia.
Combined Compression of Stimulated Brillouin Scattering and Laser–Induced Breakdown Enhanced with Sic Nanowire
Authors: Feng Lai , Zhao Yiming , Zhang Weiwei , Sun Dongsong
Published: January 2024

In this paper, the laser pulse time compression technique, based on stimulated Brillouin scattering (SBS) and passive laser–induced breakdown (LIB) series technology, is investigated. By doping a SiC nanowire in a CCl4 solution of an LIB breakdown medium, the LIB generation threshold is reduced, and the stability of the LIB compression output is improved. When OD is 0.2, the output pulse width is 254.4 ps, and the corresponding energy conversion efficiency and pulse compression rate are 34.2% and 50.2%, respectively. Our experiment proves the feasibility of this scheme.
Diagnostics of Secondary Fracture Properties Using Pressure Decline Data during the Post-Fracturing Soaking Process for Shale Gas Wells
Authors: Wu Jianfa , Ren Liming , Chang Cheng , Sheng Shuyao , Zhu Jian , Liu Sha , Xie Weiyang , Wang Fei
Published: January 2024

In addition to main fractures, a large number of secondary fractures are formed after the volumetric fracturing of shale gas wells. The secondary fracture properties are so complex, that it is difficult to identify and diagnose by direct monitoring methods. In this study, a new approach to model and diagnose secondary fracture properties is presented. First, a new pressure decline model, which is composed of four interconnected domains, i.e., wellbore, main fractures, secondary fractures, and reservoir matrix pores, is built. Then, the fracturing fluid pumping and post-fracturing soaking processes are simulated. The simulated pressure derivatives reflect five fracture-dominated flow regimes, which correspond to multiple alternating positive and negative slopes of the pressure decline derivative. The results of sensitivity simulation show that the density, permeability, and width of secondary fractures are the main controlling factors affecting the size ratio. Finally, based on the simulated pressure decline characteristics, a diagnostic method for the identification and analysis of secondary fracture properties is formed. This method is then applied to three platform wells in the Changning shale gas field in China. This study builds the correlation between the secondary fracture properties and the shut-in pressure decline characteristics, and also provides a theoretical method for comprehensive post-fracturing evaluation of shale gas horizontal wells.
Violence and Child Mental Health Outcomes in Iraq: Mapping Vulnerable Areas
Authors: Al Juboori Ruaa
Published: January 2024

Few studies have been conducted in Iraq regarding the association of violence at multiple ecological levels and child mental health outcomes. Therefore, the study objectives were (1) to conduct a nationwide analysis to explore violence at multiple socio-ecological levels and children’s mental health outcomes, and (2) to identify the most vulnerable children according to the spatial distribution of Iraqi governorates. This cross-sectional study used the 2018 Iraq Multiple Indicator Cluster Survey (MICS 6), which included 12,358 mothers or caretakers who provided complete information regarding their parenting and disciplinary practices for their children between the ages of 5 and 14. Logistic regression was employed to examine the factors associated with children’s depression and anxiety. This study showed that 22% of children had depression, while 38% experienced anxiety. Notably, children residing in Iraq’s south/central regions, specifically in areas, like Nainawa, Najaf, and Basrah, exhibited notably higher anxiety and depression. The research also showed that living in unsafe neighborhoods, women’s acceptance of domestic violence, and the use of severe physical punishment as corporal discipline were all associated with the development of anxiety and depression. This study addresses the scarcity of information on children’s mental health outcomes in Iraq at national and governorate levels, emphasizing the need for urgent national-level policy discussions to achieve key Sustainable Development Goals related to ending all forms of violence against children by 2030.
Saltwater Intrusion and Agricultural Land Use Change in Nga Nam, Soc Trang, Vietnam
Authors: Nguyen Phan Chi , Vu Pham Thanh , Khuong Nguyen Quoc , Minh Huynh Vuong Thu , Vo Huynh Anh
Published: January 2024

Under the effects of saltwater intrusion from rising sea water levels, climate change, and socioeconomic issues, the Nga Nam district in Vietnam has suffered damage to its agriculture and changes in agricultural land use. This study aimed to investigate the factors that influenced land use changes and to propose approaches to limit the changes in agricultural land use. The damage caused by saltwater intrusion on agricultural production was evaluated via the use of secondary data collected from the Department of Infrastructure Economics of the Nga Nam district in the period of 2010–2021. The results show that during the 2010–2015 period, agricultural production areas were affected in 2010, 2012, and 2015. In the period of 2015–2021, the trend of saltwater intrusion along the damaged area remarkably decreased due to the work of saltwater-preventing structures. In this period, the area of annual plants increased, while that of fruit trees decreased. In the area comprising annual plants, the area using the triple rice land use type converted into an area using the double rice and double rice–fish ones. Lands for fruit trees transitioned from mixed farming to specialized farming to raise the economic efficiency for farmers. These changes were affected by four main factors: the physical factor, the economy, society, and the environment. The environmental and economic factors were seen to play the most important role as drivers of changes in land use. The factors of saltwater intrusion and acid-sulfate-contaminated soil, consumer markets, floods, drought, profit, and investments were noted to be significant drivers in agricultural land use change. Thus, both structural and non-structural approaches are suggested to inhibit the safeguard changes in the future.