bluuebunny/crossref_metadata_2025 huggingface dataset:
WORKSHOP CLASSROOM ACTION RESEARCH UNTUK MENINGKATKAN SEMANGAT MENELITI GURU BIOLOGI SE-PROVINSI JAMBI DIMASA PANDEMI COVID-19
Authors: Aina Mia , Johan W Ervan , Natalia Desfaur
Published: April 2022

Indonesia has an HDI (Human Development Index) ranked 107 out of 185. This shows that the quality of education in Indonesia has increased but is still quite low. Therefore, it is necessary to improve the quality of education in Indonesia. Efforts to improve the quality of education is to increase the professionalism of teachers. One of the ways to improve the quality of learning by teachers is through Classroom Action Research (CAR). Based on data from the google form questionnaire distributed, it is known that 50% do not understand about classroom action research. There are even some teachers who have never done CAR. So it is necessary to conduct classroom action research workshops to provide an understanding of CAR to MGMP biology and science teachers throughout Jambi Province. This workshop is carried out online by the Zoom cloud meeting application. Participants consisted of 49 biology teachers, chemistry teachers and science teachers throughout Jambi Province. The results of this service get a positive response from the teacher and increase the teacher's understanding of classroom action research
Starlikness Associated with Euler Numbers
Authors: Bano Khadija , Raza Mohsan
Published: April 2022

Let $\psi _{E}\left(
z\right) =\sec h\left(
z\right)
=\underset{n=0}{\overset%
{\infty }{\sum
}}\frac{E_{n}}{n!}z^{n},$ where the
constants $E_{n}$ are Euler numbers. The class
$\mathcal{S}_{E}^{\ast }$
denote the class of normalized analytic functions $f$ satisfying
$zf^{\prime }(z)/f(z)\prec
\psi _{E}\left( z\right)
$. For this class, we obtain structural formula, inclusion results, and
some sharp radii problems such as radius of convexity, radius for the
class of Janowski starlike functions and radius for some other
subclasses of starlike functions. We also find sharp coefficient results
and sharp Hankel determinants for functions in the class
$\mathcal{S}_{E}^{\ast }.$
The advantage of mini electrode-equipped catheter for the radiofrequency ablation of paroxysmal supraventricular tachycardia
Authors: Choi Young , Kim Sung-Hwan , Kim Hwajung , PARK JEONG-WOOK , Ha Young Woong , Hwang You Mi , jihoon kim , Jang Sung-Won , Oh Yong-Seog
Published: April 2022

Introduction: Novel ablation catheters equipped with
mini-electrodes (ME) offer high resolution mapping for target tissue.
This study aimed to evaluate the mapping performance and efficacy of ME
catheters in radiofrequency ablation of paroxysmal supraventricular
tachycardias (PSVTs). Methods: We prospectively enrolled 136
patients who were undergoing catheter ablation of PSVT including 76
patients with atrioventricular nodal reentrant tachycardia (AVNRT) and
60 patients with atrioventricular reentrant tachycardia (AVRT) or
Wolff-Parkinson-White (WPW) syndrome. Patients were randomized to the ME
group (ablation using a 4.5mm tip ME catheter) or the control group
(ablation using a conventional 4mm tip catheter). The number of ablation
attempt and cumulative ablation time to ablation endpoints, which was
defined as an emergence of junctional rhythm in AVNRT or accessory
pathway (AP) block in AVRT/WPW syndrome were compared. Results:
During ablation procedures, discrete SP or AP electrograms were found in
27 (39.7%) patients in the ME group and 13 (19.1%) patients in the
control group. The primary study outcomes were significantly lower in
the ME group (ablation attempt number: 2.0 [1–4] vs. 3.0 [2–7]
in the ME and control group, p=0.032; ablation time: 23.5
[5.0–111.5] vs. 64.5 [16.0–185.0] seconds, p=0.013). According
to the PSVT diagnosis, ablation time to junctional rhythm was
significantly shorter in the ME group in AVNRT. In AVRT/WPW syndrome,
both ablation attempt number and ablation time to AP block showed trends
favoring the ME group. Conclusion: The novel ME catheter was
advantageous for identifying pathway potentials and reducing initial
ablation attempt number and time in PSVT ablation. (ClinicalTrials.gov
number, NCT04215640)
Utilization of Carbon Monoxide as a fuel: A greener approach for heat recuperation
Authors: Patel Deep
Published: April 2022

Carbon monoxide is one of the unrequired and environmentally harmful
by-products of various industries. A detailed design of process
equipment for utilizing carbon monoxide as a fuel in industrial premises
via Novel Zero Carbon Emission Process (NERS) is provided. A preliminary
economic analysis of the designed system is also provided to enhance its
practical viability. Based on economic evaluation, it is calculated that
one can quickly achieve a temperature of around 523.15 K (250 °C) for
water flowing at about 6 kg/s through the heat recuperation system
installed in the process equipment. Hence a significant amount of energy
that is otherwise wasted in the form of carbon emissions can be
economically recovered (having an approximate payback period of around
1.5 years, based on economic analysis and reactor design as per
bench-scale data available in the literature).
Oscillation of odd-order differential equations with a nonpositive sublinear neutral term and distributed deviating arguments
Authors: Graef John , Jadlovská Irena , Tunç Ercan
Published: April 2022

New sufficient conditions for the oscillation of all solutions to a class of
oddorder differential equations with a nonpositive sublinear neutral term
and distributed deviating arguments are established. Example are included to
illustrate the results.
Estimates on some quadrature rules via weighted Hermite-Hadamard inequality
Authors: Baric Josipa , Kvesic Ljiljanka , Pecaric Josip , Ribicic-Penava Mihaela
Published: April 2022

In this article new estimates on some quadrature rules are given using
weighted Hermite-Hadamard inequality for higher order convex functions and
weighted version of the integral identity expressed by w-harmonic sequences
of functions. Obtained results are applied to weighted one-point formula for
numerical integration in order to derive new estimates of the definite
integral values.
Euler sums of generalized harmonic numbers and connected extensions
Authors: Can Mümün , Kargın Levent , Dil Ayhan , Soylu Gültekin
Published: April 2022

This paper presents the evaluation of the Euler sums of generalized
hyperharmonic numbers H(p,q)n ?H(p,q)(r) = ?Xn=1 H(p,q)n/nr in terms of
the famous Euler sums of generalized harmonic numbers. Moreover, several
infinite series, whose terms consist of certain harmonic numbers and
reciprocal binomial coefficients, are evaluated in terms of the Riemann zeta
values.
Complete asymptotic expansions related to the probability density function of the χ2-distribution
Authors: Chen Chao-Ping , Srivastava H.M.
Published: April 2022

In this paper, we consider the function fp(t) = ? 2p?2(?2pt + p;p), where
?2(x;n) defined by ?2(x;p) = 2?p/2/?(p/2) e?x/2xp/2?1, is the density
function of a ?2-distribution with n degrees of freedom. The asymptotic
expansion of fp(t) for p ? ?, where p is not necessarily an integer, is
obtained by an application of the standard asymptotics of ln ?(x). Two
different methods of obtaining the coefficients in the asymptotic expansion
are presented, which involve the use of the Bell polynomials.
Burn skin treatment by nanoparticle – review article
Authors: Jaddoa Nihad Taha Mohammed , Ghafil Jenan A. , Zgair Ayaid Khadem
Published: April 2022

Background: The nanotechnology considers as one of the most promising technologies in the treatment of diseases and the manufacture of drugs with high efficiency. This review highlighted on the designing of nanoparticles (NPs) for therapeutics. The size of nanoparticle important in reaching to the target and get out from the body by kidney. Nanostructured and nanocrystalline nanomaterials are the two basic types of nanomaterials. The safe of nanoparticle is one of the most attractive attribute of nanoparticle when it will chose as a medicine. Dendrimers are extensively employed in therapeutic implementation because of their structural attribution of this component.  Moreover, the capsid protein of virus is extremely natural nanoparticles can be used in medicine. Nanogels can be used for biological sensors, and other biological applications and administration of pharmaceuticals. Beside that there are many nanoparticles that have many medical applications, i.e. nanodiamonds (NDs), metallic NPs, quantum dots (QDs), Silica-Based NPs (SBNPs), Lipid-Based Nanoparticles (Liposomes).

Conclusion: One of the most important applications of NPs, which was highlighted in this review, is the use of nanoparticles in the treatment of microbial contaminated burns. Finally, it can be concluded that the using of NPs and nanomaterials with no cytotoxic effect in medication are considered one of the most important technologies that have emerged in recent years.
Analysis of scientific production of refused derived fuel through scientometric and bibliometric indicators
Authors: Guedes Flávio Leôncio , El-Deir Soraya Giovanetti , Aragão Júnior Wilson Ramos , Jucá José Fernando Thomé
Published: April 2022

Constant urbanization has intensified the volume of solid urban waste generated, in addition to causing the exhaustion of landfills and the elevation of carbon in the atmosphere. New treatment technologies allow waste to be transformed, having economic value and, consequently, increasing the useful life of landfills. Energy recovery as a solution for the recovery of waste, through conversion to Refused Derived Fuel, in order to be used, for example, in industries. The aim of this study was to analyze the current state of scientific production on RDF production through scientometric and bibliometric indicators. The distribution of study sites suggests a global interest from both developed and developing countries. The most frequent terms analyzed in the word cloud of the article titles focus on words related to the energy recovery of waste and the main words in the abstracts emphasized the methods of energy recycling, life cycle and incineration. The analysis of networks by co-occurrence of words showed that the synergy occurs around the term waste, with terms that demonstrate a tendency to use solid waste as an energy source, in order to contribute to the municipal management of these materials. In addition, one of the energy conversion processes, gasification, was highlighted, pointing out that this process is one of the most applied. Finally, the potential collaborations of the factor analysis that verified two clusters focused on energy issues and related to the management of urban solid waste.
A review of the treatment techniques of VOC
Authors: Gao Min , Mao Mingming , Shi Junrui , Liu Yongqi , Chen Qiang , Li Jia
Published: April 2022

Volatile organic compounds (VOC) are important sources of environmental pollution. Several commonly used techniques for the treatment of VOC are reviewed. Recovery techniques can be classified into absorption, adsorption, condensation and membrane separation. Destruction techniques include biodegradation, photocatalysis, low-temperature plasma and combustion. The basic principle, applicable conditions, advantages and disadvantages of the above technologies are discussed. By contrast, the rotational regenerative combustion method has a broad prospect. Suggestions on the improvement of rotary regenerative combustion technology are presented. The treatment of VOC requires comprehensive consideration of the advantages and disadvantages of various technologies.
Performance evaluation of college laboratories based on fusion of decision tree and BP neural network
Authors: Yujie Chang , Weimin Gao , Chelli Karim , Muttar Ahmed K. H.
Published: April 2022

Performance evaluation can promote the continuous improvement of the laboratories in a college. It is necessary to take into account the scientific evaluation method during the process of the performance evaluation. In this paper, a performance evaluation method based on the fusion of the decision tree and BP neural network is presented. In detail, the decision tree model is used to select performance evaluation indexes with high weight. The BP neural network was adopted aiming to reduce the impact of assessment prediction of classification by non-core factors. First, the data were pre-processed by trapezoidal membership function. Then, the decision tree was generated by the C4.5 algorithm to select the evaluation indexes with high weight. Then, the BP neural network was trained with as many samples as possible by evaluation indexes; it possesses experts’ experience which can be used to predict the performance evaluation results. The method overcomes the shortages of the separate model, eliminates the disturbance of human factors and improves the accuracy of the evaluation. Experiments show that the model is feasible and effective in performance evaluation of college laboratories. The outcomes of this work can provide a scientific evaluation method for people such as researchers, college administrators and laboratory managers. Also, this paper will help them to improve the management of laboratories and provide them with decision references for constructing the laboratories.
OUTCOMES OF GLOBALISATION IN THE PROCESS OF TRANSLATION
Authors:   University of Craiova, MATIEȘ-VERBUNCU (STOIAN) Isabella-Alice
Published: April 2022

In the last decades of the 21st century, we have witnessed a substantial increasing of the phenomenon of globalisation which transcends geographical boundaries and dramatically affects technology and socio-economical development, and modern translation as well. Despite the fact English has become a world trade lingua franca, the changes made by the advent of globalisation may produce specific cultural linguistic, technological and political outcomes for the field of translation and translators. This paper proposes an attempt to grasp the relevance of globalisation and its fundamental and introspective role in the process of modern translation.
CRITICAL DISCOURSE ANALYSIS OF DONALD TRUMP’S POLITICAL SPEECH VIA TWITTER
Authors:   Doctoral School of Humanities, “Ovidius” University of Constanta, SHAMMARI Shaalan Najem Abdullah
Published: April 2022

Although social media was used in the 2008 presidential campaign, it became increasingly important in the 2016 election. Presidents have had to adopt and adapt to new technology in the past as well, and this has had a long-term effect on political discourse. Politicians now have new tools for communicating with the public, thanks to the internet and social media. An important goal of this paper is to examine how political speech has evolved over time, particularly in light of social media's role in political campaigning, and how Donald Trump used social media as a means of political communications. A discourse-historical approach of critical discourse analysis (CDA), has been applied in this study to carry out the analysis that would determine Trump's speech techniques. The results of this study demonstrate how President Trump's used language to influence his audience. Overall, this research paper will focus on Trump’s discourse strategies and how he employed them to create positive self-presentation and negative other-presentation.
JAPANESE PROVERBS BETWEEN EQUIVALENCE AND COMPARATIVE TRANSLATION FROM JAPANESE AND ENGLISH INTO ROMANIAN. AN ANALYSIS FROM THE SEMANTIC AND PRAGMATIC POINT OF VIEW
Authors:   Technical University of Civil Engineering Bucharest, Faculty of Engineering in Foreign Languages, Department of Foreign Languages and Communication, AVORNICESEI Oana-Florina
Published: April 2022

The current paper takes a comparative look at a selection of Japanese proverbs and their translation into English to their Romanian equivalents. The English translation belongs to David Galeff, the author of the book ‘Japanese Proverbs. Wit and Wisdom’ from which stems the selection of proverbs which are the object of the current analysis. The Romanian translation applies two methods. It tries to find an equivalent in Romanian, both in terms of wit i.e. wording or sense and in terms of wisdom i.e. meaning or reference. As such the two perspectives of analysis are semantic and pragmatic. The aim is firstly to find an equivalent in meaning and reference to a relevant wisdom inspired by reality and life. If such an equivalent is not found, alternative translations are attempted using other translation procedures, such as modulation or even adaptation. The theoretical framework used is the one Vinay and Dalbernet outlined in their ‘Comparative Stylistics of French and English: A Methodology for Translation’. This is a translational attempt to look towards the East and towards the West and see how different and how similar they are in the way they understand life and express that understanding. The aim of the analysis is to see to what extent it can identify corresponding ways of wording or equivalent forms of expression in Romanian for the wit and the wisdom incapsulated in the Japanese proverbs, via the English language
Slow Breathing Activates the Lateral Abdominal Muscles and Improves Physical Performance
Authors:   Kansai University Of Welfare Sciences, Kai Satoru
Published: April 2022

Slow breathing activates the internal oblique muscle. Activated the internal oblique muscle improves physical performance. Slow breathing not only activates autonomic nervous activity, but also stimulates the abdominal internal oblique muscle and other lateral abdominal muscles, leading to improved physical performance.
Effect of Acupuncture on Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Applications
Authors:   China Medical University Hospital, Wei Tzu-Hsuan
Published: April 2022

Inflammation is a common feature of disorders affecting various systems in the body, and oxidative stress can lead to an imbalance in the cellular metabolism and impaired regeneration of injured tissue. The therapeutic effect of manual acupuncture and electroacupuncture has long been studied. In this study, we conducted a literature review focusing on oxidative stress and inflammation and the therapeutic effect of acupuncture on pathological pathways. Our results reveal that through a novel light therapy technique, manual acupuncture and electroacupuncture can be combined to provide an alternative method for optimizing their therapeutic effects.
Progress in the Study of Manual Repositioning for Thoracolumbar Vertebral Body Fracture
Authors:   Luoyang Orthopedic-Traumatological Hospital Of Henan Province, Gang Zhao
Published: April 2022

Thoracolumbar vertebral fractures are the most common spinal fractures, and the traditional Chinese medicine of manual repositioning has a definite curative effect on thoracolumbar vertebral fractures, and can restore the vertebral body height to the greatest extent, release pain, reduce the rate of cement leakage and recurrent fractures. The author summarizes the progress of researches on thoracolumbar vertebral fractures by manual repositioning in order to provide reference for relevant clinical and scientific research.
Congenital cystic adenomatoid malformation: case report
Authors: Respondovesk Tatiana , Seminari Naomi , Guerra Priscilla
Published: April 2022

OBJECTIVES: To report the case of a patient with clinical presentation of congenital cystic adenomatoid malformation (MACC) during the neonatal period and discuss the diagnostic difficulty of MACC, given the wide variety and nonspecificity of symptoms that may be present at the onset of the condition. METHODS: Analysis of medical records and literature review. CASE REPORT: Patient who, in the first days of life, evolved with symptoms of progressive respiratory distress, dependent on mechanical pulmonary ventilation, without radiographic images suggestive of MACC in the evolution, making the diagnosis of the disease difficult. RESULTS: In most case reports, we see that the diagnosis was made after the neonatal period, based on the complications of the disease, during early childhood or adulthood, impairing the patients cure. CONCLUSION: Although the disease is rare and has a high potential to evolve with complications, the patient was diagnosed in a timely manner to undergo the surgical procedure and to progress uneventfully.
Primary cardiac congenital yolk sac tumor - case report and literature review
Authors: Oliveira Bruno , Rodrigues Analiz , Sejas-Soliz Carmen , Bem Thiago , Grossi Vitor , Odone Filho Vicente
Published: April 2022

Intracardiac tumors are rare, especially in the neonatal period. We present an infant of 1-year and 11 months old with a diagnosis of an intracardiac antenatal tumor, along with literary review on the topic. The referred tumor evolved rapidly with metastases at the time of diagnosis. A biopsy of a pulmonary metastatic lesion was performed, which showed germinative cells tumor (GCT). The patient underwent intensive care treatment, and is now in good condition, following the proposed treatment with chemotherapy for TCG.
Oligosymptomatic Eisenmenger syndrome in adolescent
Authors: Franco Vanessa , Gonçalves Claudia , Biokino Renan , Rocca Andrey , Dobr Giovani , Parreira Yasmin , Silva Bruno , Berigo João
Published: April 2022

Eisenmenger syndrome is characterized by high pulmonary pressure, caused by a high pulmonary flow state, with inverted shunt (right-to-left) or bidirectional. The condition is a complication of a congenital heart defect not repaired and the diagnosis is based on clinic, echocardiogram and cardiac catheterization. The case reported is a 13 years old teenager that had lost the follow-up a year after the diagnosis with 5 years old. She returned with dyspnea, worsening of echocardiographic patterns, pulmonary hypertension and under weight. Without surgical indication, the patient were followed up clinically for a year and evolved with a similar dyspnea pattern, healthy weight and normal neurological development. ES is an extreme condition in which, due to a previous cardiac defect, pulmonary vascular resistance becomes greater than systemic resistance and the flow reverses irreversibly, leading to high morbidity, mainly due to hypoxemia. Besides the surgical treatment, some drug options may be used, such as: bosentan, PDE-5i, prostanoids and sildenafil associated with bosentan. Bosentan is the first choice drug, the others should be evaluated individually. Despite the aforementioned therapeutic guidelines, it is essential to avoid congenital heart defects from reaching this dramatic picture. The oligosymptomatic evolution of the case describes a possibility of the natural history of this entity.
Migration trends in Postcolonial Kenya: Positive and negative aspects (1960-2010)
Authors: Karpov Grigory
Published: April 2022

The article analyzes migration processes in Kenya during the independence era. Internal and external trends were analyzed in detail, including the relocation of the population within the country. The main channels and composition of emigration and immigration are highlighted. The factors causing the increasing outflow of qualified specialists from the country and the constant influx of refugees from neighboring African states with Kenya have been studied. The author paid special attention to the problem of illegal migration and the slave trade in modern Kenya. During the work on the material, a broad methodological base was used, including comparative analysis, problem-historical and civilizational approaches. The key factors provoking large-scale migration from Kenya include demographic pressure, high unemployment, ethnopolitical conflicts and environmental problems. The backbone of Kenyan emigrants is made up of highly qualified specialists. The bulk of people coming to the country are refugees from neighboring African States. The transit of migrants through Kenya is also very noticeable and has an obvious criminal and corruption connotation. Kenyan communities abroad do not lose touch with their historical homeland and serve as an important source of foreign exchange earnings for the country's economy. The Kenyan authorities do not see a threat to security in migration processes, consistently and pragmatically extracting maximum preferences from the current situation in this area in order to comply with national interests.
The Origin of the Hebrew nithpaal: A Sociolinguistic Proposal
Authors: Donnelly-Lewis Brian
Published: April 2022

This paper offers a socio-historical linguistic account of the origin of the Rabbinic Hebrew (RH) nithpaal, positing a contact-induced morphological compromise between the Hebrew niphal and the hithpael in which the usage of latter stem has been influenced by the Aramaic -t stem (hithpaal). To prove this, I outline the history of the relationship between the niphal and hithpael, focusing on a few post-exilic examples that display an equivalence of the meaning and use of the two stems, especially the growth of the passive hithpael. As such, the traditional account of the derivation of the nithpaal in RH as a blend of hithpael and niphal is argued to be a morphological compromise as the result of Hebrew-Aramaic bilingual language processing. This conclusion allows a presentation of RH nithpaal in its social and historical context, suggesting that, as a morphological compromise, it perhaps also indicates a linguistic reflex of a language community under threat of language extinction.
The High Voltage Source for the ELV-15 Accelerator
Authors: Kuksanov N. K. , Vorobev D. S. , Salimov R. A. , Fadeev S. N.
Published: April 2022

The article describes modelling of the high voltage source of the ELV-15 accelerator. The electromagnetic parameters of the rectifier, the magnet filed distribution, the parameters of primary and secondary winding are considered. Ripples and stability of the accelerating voltage are evaluated. The strength of the electric field in the source is considered.
Modern server ARM processors for supercomputers: A64FX and others. Initial data of benchmarks
Authors: Кузьминский Михаил Борисович
Published: April 2022

Дан сравнительный анализ производительности серверных ARM/̄процессоров, используемых на суперЭВМ или ориентированных в частности на высокопроизводительные вычисления (HPC). В стартовый анализ производительности были отобраны Fujitsu A64FX, Marvell ThunderX2 и Huawei Kunpeng 920. Обзор производительности для HPC сосредоточен в первую очередь на тестах и приложениях для A64FX, поддерживающего более длинные, чем у других ARM/̄процессоров, вектора и имеющего большую пиковую производительность. Производительность A64FX сопоставлена с соответствующими данными для Intel Xeon Skylake и Cascade Lake, и AMD EPYC с Zen 2 и 3 (Roma и Milan), а также с GPU Nvidia V100 и A100. Сформулирован краткий набор потенциальных плюсов и минусов микроархитектуры A64FX. Сопоставлены данные о производительности, получаемой с применением различных компиляторов для A64FX. Сформированы признаки, когда A64FX дает обычно преимущества в производительности относительно x86-64, а когда — проигрывает x86-64.

Подтверждается, что применение A64FX в суперЭВМ может расти далее. Возможно, гегемония x86-64 в HPC будет уменьшаться, в том числе за счет расширения применения серверных ARM/̄процессоров. Однако проведенный анализ A64FX и ожидаемых в ближайшее время новых процессоров архитектуры AArch64 показал, что ведущим в этом процессе не обязательно окажется A64FX.
A learner-centered global oral health education approach
Authors: Farokhi Moshtagh R. , Estacio Alvin , English Dana Kiefer
Published: April 2022

Objectives:

The present research indicates an increased interest in global health among dental students. We focused on developing our future dental practitioners with the skills and capacity to treat underserved populations as international experiences.

Materials and Methods:

This pilot explored the perspective of dental learners regarding global oral health knowledge who had experienced mission trips. Participants were assessed with a validated global oral health survey to understand their existing knowledge. Gaps in training were noted and a global oral health interactive module was created to address international community service learning approaches. Later, all students who intended to participate in a global oral health education or mission trip were administered the same validated pre-test. Finally, on the completion of mission trips or global oral health experiences, the same post-global oral health questionnaire survey was administered to assess knowledge gained.

Results:

Thirty-two dental students (Female = 18 and Male = 14) and learners who had completed mission trips to Jamaica and the Dominican Republic were invited to complete the pre-survey. Twenty-seven students completed the pre-survey in its entirety. About 41% (11/27) were not aware of developed and developing countries’ oral healthcare systems. Participant dental learners (56%) expressed limited cultural competency. They also expressed the lack of global health ethics (52%) awareness (knowledge).

Conclusion:

Results indicated that students benefited from a structured global oral health module, where their perspectives shifted positively. The results suggested that a shift from “mission trip” perspectives to a global oral health readiness is feasible as a student empowerment approach.
A case of pulmonary artery sling, unilateral lung hypoplasia, and congenital heart disease
Authors: Ashong Joyce , Kwarteng Owusu Sandra , Yiadom Adwoa Pokua Boakye , Wireko Brobby Naana
Published: April 2022

Vascular rings are rare congenital anomalies that primarily result from an embryological derangement of the paired aortic arches or branching pulmonary arteries. They make up <1% of all cardiac defects. Double aortic arch and right-sided aortic arch with the left ligamentum arteriosum are the most common types, making up 85– 95% of cases, with pulmonary artery slings making up about 10% of cases. The prevalence is estimated as 59 per million children with very few cases reported worldwide. The clinical presentation is variable and this includes severe acute life-threatening episodes, recurrent apnea, severe respiratory distress, feeding difficulties persistent cough, wheezing, or stridor. In some cases, affected individuals may be completely asymptomatic. A high index of suspicion is needed to suspect and diagnose vascular rings as they are uncommon but surgically treatable. We present a case of a 5-day-old term neonate referred to our facility with respiratory distress associated with stridor which started 12 h post-delivery.
Solution Processable Polytriazoles from Spirocyclic Monomers for Membrane-based Hydrocarbon Separations
Authors: Bruno Nicholas , Mathias Ronita , Zhu Guanghui , Ahn Yun-Ho , Rangnekar Neel , Johnson J.R. , Hoy Scott , Bechis Irene , Tarzia Andrew , Jelfs Kim , McCool Benjamin , Lively Ryan , Finn MG
Published: April 2022

The thermal distillation of crude oil mixtures is an energy intensive process conducted on massive scale worldwide. Membrane-based separations are, in principle, much more efficient in energetic terms, if useful fractions can be obtained. We describe here a family of spirocyclic polytriazoles for membrane applications prepared by a convenient step-growth method using copper-catalyzed azide-alkyne cycloaddition, providing very fast reaction rates, high molecular weights and solubilities in common organic solvents, and non-interconnected microporosity. Fractionation of whole Arabian light crude oil and atmospheric tower bottoms feeds using these materials significantly enriched the low-boiling components and removed trace heteroatom and metal impurities, demonstrating opportunities to reduce the energy cost of crude oil distillation with tandem membrane processes. Membrane-based molecular separation under these demanding conditions is made possible by high thermal stability and a moderate level of dynamic chain mobility leading to transient interconnections between micropores, as revealed by calculations of static and swollen pore structures.
Ensemble Simulations and Experimental Free Energy Distributions: Evaluation and Characterization of Isoxazole Amides as SMYD3 Inhibitors Inhibitors
Authors: Wan Shunzhou , Bhati Agastya , Wright David , Wall Ian , Graves Alan , Green Darren , Coveney Peter
Published: April 2022

Optimization of binding affinities for ligands to their target protein is a primary objective in rational drug discovery. Herein we report on a collaborative study that evaluates various compounds designed to bind to the SET and MYND domain-containing protein 3 (SMYD3). SMYD3 is a histone methyltransferase and plays an important role in transcriptional regulation in cell proliferation, cell cycle and human carcinogenesis. Experimental measurements using the scintillation proximity assay show that the distributions of binding free energies from a large number of independent measurements exhibit non-normal properties. We use ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) and TIES (thermodynamic integration with enhanced sampling) protocols to rank the binding free energies and to provide detailed chemical insight into the nature of ligand−protein binding. Our results show that the 1-trajectory ESMACS protocol works well for the set of ligands studied here. Although one unexplained outlier exists, we obtain excellent statistical rankings across the set of compounds from the two protocols. ESMACS and TIES are again found to be powerful protocols for the accurate comparison of the binding free energies.
Direct Synthesis of Mesoionic Carbene (MIC) Stabilized Gold Nanoparticles from 1,2,3-Triazolium Salts
Authors: Porcheron Alexandre , Sadek Omar , Ba Sowid Salem , Bridonneau Nathalie , Hippolyte Laura , Mercier Dimitri , Marcus Philippe , Chauvier Clément , Chanéac Corinne , Fensterbank Louis , Ribot François
Published: April 2022

Significant achievements have been reported in the last few years regarding the stabilization and functionalisation of gold nanoparticles (AuNPs), mainly through the use of thiols and imidazolylidene N-heterocyclic carbenes capping ligands. Herein, we report that mesoionic carbenes (MICs) ligands, based on the 1,2,3-triazol-5-ylidene scaffold, allow the expeditive preparation of AuNPs of exceptional stability through a simple and straightforward one-pot protocol directly from triazolium salts and discrete Au(III) sources. Control over the size of the AuNPs has been achieved by varying the Au/ligand ratio as well as the nature of the triazolium salts, the latter being facilitated by the ease of synthesis of the MIC precursors through click chemistry. Characterisation of these MIC-AuNPs by X-ray photoelectron spectroscopy (XPS) hints at the exclusive presence of MICs on the nanoparticle surface.
A straightforward method to quantify the electron-delocalizing ability of pi-conjugated molecules
Authors: Bradley David , Branley Callum , Peeks Martin
Published: April 2022

Electronic delocalization is essential to the properties of pi-conjugated molecules. We introduce the inter-fragment delocalization index (IFDI) as an easy-to-use computational method for quantifying the electronic delocalization in pi-conjugated oligomers and molecular wire models. We show that the IFDI is related to the torsion barriers of pi-conjugated dimers, and to the single-molecule conductance of several pi-conjugated fragments. The IFDI is a useful screening technique for comparing different pi-conjugated subunits as components in organic electronics, since it can quantify the influence of substitution position, structure, and (anti)aromaticity on delocalization.
Virtual reality sampled pathways guide free energy calculation of protein-ligand binding
Authors: Deeks Helen , Zinovjev Kirill , Barnoud Jonathan , Mulholland Adrian , van der Kamp Marc , Glowacki David
Published: April 2022

We describe a novel two-step approach for combining cloud-mounted interactive molecular dynamics in virtual reality (iMD-VR) with free energy sampling (FES) approaches to quantitatively explore the dynamics of biological processes at the molecular level. The combined approach we refer to as the iMD-VR-FES protocol. Stage one involves using a state-of-the-art iMD-VR framework to quickly sample a diverse range of protein-ligand unbinding pathways, benefitting from the sophistication of human spatial and chemical intuition. Stage two involves using the iMD-VR-sampled pathways as initial guesses for defining a path-based reaction coordinate from which we can obtain a corresponding free energy profile using FES methods. To investigate the performance of the method, we apply iMR-VR-FES to investigate the unbinding of a benzamidine ligand from a trypsin protein. Unbinding free energies calculated using iMD-VR-FES show good internal consistency, and broadly agree with previous literature values. Moreover, the resulting free energy profiles can distinguish energetic differences corresponding to various protein-ligand conformations (e.g., helping to identifying favorable vs. unfavorable pathways) and also enable identification of metastable states along the unbinding pathways. The two-step iMD-VR-FES approach offers an intuitive way for researchers to test various hypotheses of dynamical and conformational change, in order to quickly obtain both qualitative and quantitative insight.
Influence of Sepiolite Addition Methods and Contents on Physical Properties of Natural Rubber Composites
Authors: Hayeemasae Nabil , Adair Ajaman , Rasidi Mohamad Syahmie Mohamad , Jitsopin Patiwarada , Masa Abdulhakim
Published: April 2022

The influence of sepiolite loadings (1-10 phr) and sepiolite addition procedures (mill and latex mixing approaches) on properties improvement of natural rubber composites was investigated. The viscosity, curing behavior, and tensile test were used to assess the property changes whereas the rubber-filler interactions was confirmed by using stress relaxation, swelling, Mooney-Rivlin and rheological methods. It was found that the characteristics of rubber composites influenced by both mixing methods and filler contents. Comparing between two different mixing methods, the slower stress relaxation rate and less swelling capability were achieved from mill mixing technique. This method also lowered the strain where the upturn of stress was occurred as suggested by Mooney-Rivlin plot. The greater properties enhancement of composites was obtained from milling method because of the better rubber-filler interactions, probably as a result of the nature of filler used. The greatest tensile strength improvement was achieved at 1 phr sepiolite loading where the smallest damping characteristics (tan ????) indicating the highest elastic behavior were obtained as revealed by rheological measurements. The simplicity of production and shortened step of milling procedure would be more favorable than the latex mixing approach for fabrication sepiolite filled rubber composites.
Antifungal Analysis of Papaya Seed Extracts and Biosynthesized Silver Nanoparticles
Authors: Simangunsong Tri Lestari , Putra Ananda , Ginting Sahna Ferdinand , Wardhani Fiska Maya , Abdullah Hairus , Ikhtiari Refi
Published: April 2022

The purpose of research is to investigate the antifungal potential of papaya seed extract and the biosynthesis of silver nanoparticles by C. papaya extract. Here we report 14 secondary metabolites from C. papaya seed extract detected by gas chromatography mass spectroscopy. Bioactive components were majority classified as fatty acid-methyl ester, heterocyclic amides, and phenolic compounds. The proposed mechanisms of those metabolites on inducing antifungal activity were comprehensively studied. We found that the n-hexane fraction was the solely fraction to produce the silver nanoparticles. Scanning electron images presented the aggregation and evenly distribution of spherical silver nanoparticles. The XRD exhibited the crystallization of the bio-organic synthetic phase based on the specific spectrum of 2-theta at 38.9 degree with miller index [1,1,1]. The particle size analyzer also confirmed the nanoscale of synthesized materials as in the average size of 92.1 nm (Z) and 0.406 (PI). Antifungal effects were examined by disc diffusion method upon each fraction with varying concentrations of 25%, 50%, 75%, and 100% (w/w) against C. albicans. ANOVA analysis showed no significant difference among all fractions tested (p > 0.25). The antifungal activity was categorized as a moderate effect with the mean of inhibition zone ranging from 6.1 to 6.8 mm. However, the potential of papaya seed extract is relatively better than the papaya leaves extract, as previously reported. We suggest further studies on the molecular docking of the secondary metabolites against nanoparticle, and specific biomolecular analysis according to the mechanism of action.
A Comparative Study of Photobiological and Photophysical Characteristic of Meso-Tetraphenylporphyrin and Meso-Tetraphenylchlorin as Photosensitizers for Photodynamic Therapy
Authors: Djalil Asmiyenti Djaliasrin , Susanti Susanti , Erlita Fuji Marsela , Mustafa Ari Fariz , Hamad Alwani , Suwandri Suwandri
Published: April 2022

Photosensitizer modifications are needed to improve the performance of Photodynamic Therapy (PDT) for the treatment of cancer. This work appraised the photophysical and photobiological characteristics of tetrapyrrolic macrocycles. Meso-tetraphenylporphyrin (m-TPP) and meso-tetraphenylchlorin (m-TPC) represent non-reduced and reduced pyrrole rings tetrapyrrolic macrocycles, respectively. The absorption spectra of m-TPP and m-TPC were performed. The relative quantum yield of singlet oxygen (ΦΔ) was measured at two different pH (6.3 and 7.4) relative to chlorine e6. Dark toxicity was monitored using the MTT assay on breast cancer T47D and NIH 3T3 cell lines. In addition, the stability of the compounds under indirect sunlight was also observed. The absorption maxima of the Q1 band of both compounds are at a longer wavelength. The Q1 peak of a reduced pyrrole ring is more intense than the non-reduced pyrrole ring with the lowest energy transition undergoing a redshift. The singlet oxygen generations are higher at pH 7.4 for both compounds with them-TPC showed a higher relative singlet oxygen quantum yield. In addition, the photosensitizers are stable under indirect sunlight radiation. m-TPC has higher cellular uptake than m-TPP in both cell lines. The dark toxicity of m-TPC is higher than m-TPP in T47D cells. However, the opposite occurred in observing dark toxicity in the NIH 3T3 cell line. Our study concludes that the cellular uptake and ΦΔ can be enhanced by reducing the pyrrole ring of the tetrapyrrole macrocycle. Therefore, m-TPC proved to be a better photosensitizer than m-TPP.
Dynamic Modeling and Forecasting Data Energy Used and Carbon Dioxide (CO2)
Authors: Russel Edwin , Wamiliana Wamiliana , Saibi Nairobi , Warsono Warsono , Usman Mustofa , Daoud Jamal I.
Published: April 2022

The model of Vector Autoregressive (VAR) with cointegration is able to be modified by Vector Error Correction Model (VECM). Because of its simpilicity and less restrictions the VECM is applied in many studies. The correlation among variables of multivariate time series also can be explained by VECM model, which can explain the effect of a variable or set of variables on others using Granger Causality, Impulse Response Function (IRF), and Forecasting. In this study, the relationship of Energy Used and CO2 will be discussed. The data used here were collected over the year 1971 to 2018. Based on the comparison of some criteria: Akaike Information Criterion Corrected (AICC), Hannan-Quin Information Criterion (HQC), Akaike Information Criterion (AIC) and Schwarz Bayesian Criterion (SBC) for some VAR(p) model with p= 1,2,3,4,5, the best model with smallest values of AICC, HQC, AIC and SBC is at lag 2 (p= 2). Then the best model found is VECM (2) and further analysis such as Granger Causality, IRF, and Forecasting will be based on this model.
IMPROVEMENT OF TRAINING TECHNOLOGIES IN PROFESSIONAL TRAINING OF DENTISTS
Authors: V.V. Balin , E.G. Borisova , V.A. Zheleznyak , N.A. Borisov
Published: April 2022

Abstract. The high level of knowledge and practical skills of graduates of the Military Medical Academy named after S.M. Kirov, the desire and ability of teamwork to a certain extent determine the development of dentistry. The quality of education, set by federal educational standards, is possible through a modular organization of education. The modularity of training makes it possible to quickly update the educational program and take into account the developmental features of a given region and the requirements of employers. The system of specialty and additional professional education today implies the use of simulation training, the introduction of training models based on professional, contextual, gaming and information-computer technologies, which makes it possible to improve the professional training of future dentists. Based on this, there is a need to form more modern forms of education. The aim of the study. To conduct a comparative analysis of the possibilities of optimizing educational technologies in the preparation of a dentist with the introduction of competency-oriented classes into the training program aimed at teaching the dentist the skills of interaction with patients and medical staff. Material and methods. The object of the study were students, students and cadets of the Military Medical Academy, studying in the profile "Dentistry". The criteria for assessing the quality of education were based on the performance rating of cadets and students, as well as the results of the state final certification. Results and discussion. It was noted that in practical classes, students practically stopped accepting patients. Therefore, the role of work practice should include not only the development of practical skills, but also training in communication skills in the dental department (clinic) with patients and medical colleagues. The use of simulation training methods, which are actively introduced into the education system at the Department of General Dentistry of the Military Medical Academy named after. S.M. Kirov, is a learning process in which the student performs actions in an environment that simulates a real one, using phantom learning tools. Working on one phantom-simulator at once by several students, acting doctors of various dental specialties, helps to form team skills in treating a patient. Conclusions. Another important technology in the education of a dentist is work practice. The most optimal form for teaching practical skills is classes in simulation or phantom centers at dental clinics, which should provide multidisciplinary thinking through the interaction of students from different dental specialties. A team approach reduces the number of complications, improves the quality of dental care, and increases patient satisfaction with dental care.