bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarqueurs de l’insuffisance cardiaque
Authors: Chenevier-Gobeaux Camille
Published: February 2025

L’insuffisance cardiaque affecte environ 500 000 Français et est une des premières causes d’hospitalisation. De récentes évolutions dans la définition de cette pathologie, la meilleure détection des formes à fraction d’éjection préservée et l’avènement de nouvelles thérapeutiques laissent entrevoir de nouvelles indications des biomarqueurs dans sa prise en charge. Si l’intérêt des peptides natriurétiques BNP et NT-proBNP est bien établi pour le diagnostic et la stratification du risque d’insuffisance cardiaque, en revanche il est discutable pour son suivi thérapeutique en raison de l’usage d’inhibiteurs (sacubitril) d’enzymes (néprilysine) dégradant ces neuro-hormones.
Augmentation isolée de la parathormone sérique : quelle stratégie diagnostique ?
Authors: Borderie Didier
Published: February 2025

La détermination de la concentration sérique de la parathormone (PTH) est très fréquemment prescrite dans le cadre de l’exploration du métabolisme phosphocalcique et osseux ainsi que d’une insuffisance rénale chronique. Il n’est pas rare que le biologiste soit confronté à son augmentation, sans que la calcémie et de la phosphatémie soient modifiées. Cette anomalie est le plus souvent la conséquence d’une hyperparathyroïdie secondaire, mais elle peut dans certains cas être observée chez des patients atteints d’hyperparathyroïdie primitive normocalcémique. La démarche diagnostique consistera, dans un premier temps, à éliminer les causes d’hyperparathyroïdie secondaire à une carence en vitamine D, à des apports calciques insuffisants ou à la prise de médicaments interférant avec le métabolisme calcique, et à exclure une hypercalciurie consécutive à une fuite urinaire de calcium. Si aucune de ces causes ne peut être retenue et que l’augmentation isolée de la parathormonémie est confirmée lors de l’analyse d’au moins un autre échantillon sanguin quelques semaines plus tard, le diagnostic d’hyperparathyroïdie primitive normocalcémique pourra être envisagé. Une épreuve de charge calcique sera une aide importante pour certifier ce diagnostic si la sécrétion de PTH est insuffisamment freinée lors de cette épreuve.
Traitements anticoagulants et cirrhose
Authors: De Raucourt Emmanuelle , Gouin-Thibault Isabelle
Published: February 2025

La cirrhose est un état prédisposant à la fois à un risque thrombotique et hémorragique, variant selon sa gravité et les conditions cliniques associées. Bien que les études soient peu nombreuses et de qualité variable, il est admis que le patient cirrhotique n’est pas protégé vis-à-vis du risque de survenue d’une thrombose veineuse profonde et d’un accident vasculaire cérébral ischémique. La thrombose de la veine porte est fréquente, tout particulièrement à un stade avancé de la maladie. La problématique de l’anticoagulation par dérivés hépariniques est liée à la diminution de synthèse de l’antithrombine. Le maniement des AVK chez ces patients est délicat du fait de la baisse des facteurs de la coagulation. L’INR pouvant être élevé avant même l’instauration d’un traitement, en l’absence de données fiables, l’objectif thérapeutique reste d’atteindre une valeur comprise entre 2 et 3. Les AOD sont une alternative attrayante chez les patients cirrhotiques. Les données actuelles semblent montrer une efficacité et une sécurité d’emploi de ces médicaments, au moins similaires à celles des AVK dans le traitement de la thrombose veineuse porte et de la fibrillation atriale non valvulaire chez les patients cirrhotiques avec un score de Child-Turcotte-Pugh (CTP) A et B.
Variación de la población y migraciones en España durante la pandemia de Covid-19: la resiliencia de los municipios turísticos
Authors: Reus-Pons Matias , Petrus Bey Joana Maria , Coll-Ramis Miquel Àngel
Published: February 2025

Esta investigación ha analizado los cambios en las dinámicas poblacionales y en los patrones de movilidad en España durante la pandemia de COVID-19, con un enfoque novedoso que distingue entre zonas turísticas y no turísticas, y entre zonas turísticas de costa y de interior. La relevancia de este estudio radica en la importancia del sector turístico en la economía española y en el impacto que la pandemia ha tenido en esta industria, lo que ha afectado a la situación laboral y económica de buena parte de la población residente en zonas turísticas. A partir de los datos de población de los municipios españoles durante el periodo de la pandemia, se ha realizado un análisis de regresión de mínimos cuadrados ordinarios para evaluar las tendencias observadas. Los resultados indican que los municipios de carácter urbano tendieron a experimentar saldos migratorios menores a los experimentados por los municipios de carácter no urbano, contrastando claramente con la situación acontecida durante los años previos a la pandemia. Además, se observó que los municipios de tamaño intermedio presentaban variaciones en función de su carácter turístico y/o costero. Las principales conclusiones de este estudio son que la pandemia ha tenido un impacto significativo en las dinámicas poblacionales y en los patrones de movilidad en España, y que la distinción entre zonas turísticas y no turísticas es relevante para entender estos cambios.
Transmettre l’horreur : Annihilation (2014) comme réécriture de Heart of Darkness (1899)
Authors: Rider Georges Pillegand-Le
Published: February 2025

Cet article explore les résonances de Heart of Darkness de Joseph Conrad dans le roman Annihilation de Jeff VanderMeer. L’écrivain contemporain, figure phare du New Weird, reconfigure la manière dont l’humain envisage son rapport au non-humain. Partant de la littérature éco-critique qui existe sur Heart of Darkness, l’analyse proposée en applique les constats à VanderMeer. Puisque des scènes et motifs du roman de Conrad sont repris explicitement, il s’agit aussi de comprendre comment Annihilation s’en affranchit. L’étude replace donc l’œuvre d’une part dans le genre hybride du New Weird, qui rompt avec les ambiances de Joseph Conrad et certains de ses positionnements ; et, d’autre part, dans un type de récits, celui des invasions extraterrestres, qui, par le prisme d’une compréhension de l’humain et de son environnement terrestre, offre des réflexions particulièrement stimulantes. Dans un récit où la “horror” de Kurtz devient, chez VanderMeer, l’“annihilation” que hurle une psychologue mourante, l’analyse s’attellera enfin à réfléchir aux symboliques de pouvoir et aux capacités d’agir des personnages. Bien que les agentivités plurielles que les deux œuvres imaginent se répondent, Annihilation parvient à dépasser les limites de ce qui était envisagé dans Heart of Darkness en proposant de nouvelles subjectivités.
Dalla “Strategia di bioeconomia” alla “Visione a lungo termine” della Commissione europea: quale sostenibilità per le aree rurali?
Authors: Ciervo Margherita
Published: February 2025

L’obiettivo di questo articolo è analizzare gli impatti attuali e a lungo termine della Strategia di bioeconomia della Commissione europea al fine di definire i possibili scenari per le aree rurali e valutarne la loro sostenibilità. L’attenzione è posta sui principali settori economici, con particolare riguardo al lavoro e al giro d’affari, al fine di comprendere che tipo di economia e di attività sono destinate alle aree rurali, così come i loro impatti territoriali. A questo fine sono stati analizzati i principali documenti e i dati della Commissione europea riguardanti la bioeconomia e la pianificazione a lungo termine per le aree rurali, così come dati scientifici recenti per verificare l’impatto sulle foreste della bioeconomia. L’analisi rivela che le aree rurali europee sono destinate a essere convertite inizialmente in produttori di biomassa a grande scala per la produzione energetica e industriale, successivamente in siti di bioraffinerie. Tali cambiamenti produrranno gravi effetti sul paesaggio, l’ambiente, la biodiversità, l’utilizzazione delle terre e l’economia locale. Di conseguenza, gli scenari per le aree rurali non sembrano né sostenibili né redditizi, in particolare per i Paesi del Sud e dell'Est dell'Unione europea.
Cloud-Native AI Applications Designing Resilient Network Architectures for Scalable AI Workloads in Smart Education
Authors: Jorepalli Sunil Kumar Reddy
Published: February 2025

In the era of digital transformation, cloud-native AI applications have become integral to the evolution of smart education and sustainable learning environments. This chapter explores the design and implementation of resilient network architectures tailored for scalable AI workloads within these domains. It delves into the challenges of optimizing AI-driven educational platforms, addressing concerns such as network reliability, scalability, and cost-effectiveness. By leveraging cloud-native technologies, microservices, and edge computing, this chapter outlines strategies for creating flexible, scalable, and fault-tolerant systems that adapt to the dynamic demands of modern learning environments. Case studies from real-world applications in smart classrooms and online education platforms highlight the practical implications and benefits of these architectures. The chapter further emphasizes the role of sustainability in educational technology, focusing on energy-efficient infrastructure and cloud resource management to ensure environmentally responsible AI implementations.
Innovative Trends in the Rapid Evolution of Machine Learning Techniques Fostering Efficient and Responsible AI Development for Smart Education
Authors: Quraishi Suhail Javed , Pathak Sonal , Dadhich Priyanka
Published: February 2025

This Chapter explores the innovative trends in the rapid evolution of machine learning techniques and their implications for fostering efficient and responsible AI development in the context of smart education and sustainable learning. As educational environments increasingly integrate AI-driven solutions, it becomes essential to address the ethical, pedagogical, and technological challenges that arise. This study examines cutting-edge machine learning algorithms, their applications in personalized learning experiences, and the impact of data-driven decision-making on educational outcomes. Furthermore, the paper emphasizes the importance of ethical considerations, transparency, and inclusivity in AI development to ensure that technological advancements enhance learning opportunities for all. By highlighting case studies and best practices, this research aims to provide insights into the future of AI in education, advocating for sustainable approaches that prioritize learner engagement and educational equity.
Predictive Scheduling in the Age of AI
Authors: Shinde Rohit
Published: February 2025

Predictive scheduling powered by AI is transforming the way project timelines are managed in sustainable learning environments. This chapter explores how AI-driven predictive models optimize scheduling by analyzing historical data, resource availability, and project complexity. By automating timeline adjustments and forecasting potential delays, AI enhances project efficiency and minimizes resource wastage. The implementation of predictive scheduling in educational technology projects ensures more adaptive, scalable, and sustainable learning environments. This chapter also discusses the key benefits, challenges, and future implications of AI-based predictive scheduling in EdTech development.
Sustainable Curriculum Design and Development
Authors: Vettriselvan R. , Ramya R.
Published: February 2025

In increasingly sophisticated urban environments, smart cities emerged as a focal point for innovation and sustainability. This chapter investigates the role of education in fostering sustainable urban futures through curricula that respond to the dynamic needs. The convergence of technology, pedagogy, and sustainability within educational frameworks is pivotal in preparing learners to navigate and contribute to advanced urban landscapes. Sustainable curriculum design incorporates principles of environmental stewardship, economic viability, and social equity. This chapter examines how integrating these principles into educational programs cultivates a sustainability mindset among learners, preparing them for active participation in sustainable development. It explores the role of smart technologies, innovative pedagogies, and ecological literacy in enhancing educational outcomes. Through global case studies, challenges, and strategies, this chapter equips educators, policymakers, and curriculum developers with the tools to support sustainable development in smart cities.
Cultivating a Positive Ethos of Employee Experience Through Culture of Ubiquity
Authors: Alamelu R. , Dinesh S. , Nalini R. , Shobhana N. , Amudha R.
Published: February 2025

In today's competitive landscape, employee experience (EX) has emerged as a pivotal factor influencing organizational success. EX encompasses the perceptions and interactions employees have throughout their journey within a company, from recruitment to exit. The COVID-19 pandemic has significantly reshaped employee expectations, prompting organizations to adopt more flexible, inclusive, and employee-cantered policies. Key elements of EX include workplace culture, meaningful work, flexibility, digital transformation, and effective leadership. Ubiquitous leadership, characterized by distributed authority and inclusive practices, enhances collaboration and innovation across all levels of an organization. Additionally, the integration of Artificial Intelligence (AI) offers transformative potential in EX by personalizing learning, streamlining recruitment, and enhancing onboarding experiences. By prioritizing these elements, organizations can foster a more engaged and satisfied workforce, ultimately driving improved performance and long-term success. This study explores the critical relationship between employee experience and ubiquitous leadership, highlighting the need for implementing the Artificial Intelligence based solutions for organizations to reimagine their strategies in response to evolving employee expectations.
The Impact of Positive Leadership on Employee Engagement, Productivity, and Talent Retention in the Era of Artificial Intelligence
Authors: Farinha João , Pina Maria de Fatima Alves
Published: February 2025

In recent years, Artificial Intelligence (AI) has reshaped workplace dynamics, influencing leadership, employee engagement, productivity, and talent retention. This paper examines the key role of positive leadership in enhancing engagement, boosting productivity, and supporting talent retention in the AI-driven work environment. Positive leadership—defined by trust, empowerment, and optimism—emerges as essential for managing the challenges of increased human-machine collaboration. By reviewing empirical studies and theoretical frameworks, this research explores how leaders can create a culture of engagement, increase productivity, and retain talent by leveraging AI to complement, rather than replace, human abilities. Additionally, the paper addresses shifting employee expectations for leadership in AI-enhanced workplaces and offers insights into aligning leadership practices with technological progress. The study concludes with practical implications for businesses aiming to succeed in the AI era and suggestions for future research.
Employer Branding Strategies in the Employee Experience
Authors: Joaquim Ana Filipa , Costa Tiago
Published: February 2025

This chapter explores the significance of Employer Branding as a strategy for attracting and retaining talent in competitive markets. Effective Employer Branding enhances an organization's appeal to qualified candidates, fosters employee engagement and alignment with corporate culture, and strengthens corporate image, thus promoting long-term success. Using questionnaires for data collection, findings indicate that Employer Branding significantly influences talent acquisition and retention, confirming its essential role in organizational sustainability and competitiveness.
Leadership's Role in Fostering a Resilient Organizational Culture
Authors: Kayyali Mustafa
Published: February 2025

This chapter addresses the crucial role that leadership plays in establishing a resilient organizational culture, with a focus on business continuity management. In today's uncertain corporate climate, resilience has emerged as a vital aspect of sustaining organizational success, particularly in times of crisis and turmoil. The article investigates the interconnection between leadership practices and resilience, identifying leadership styles that contribute to adaptability, flexibility, and psychological safety. By building a culture that embraces change and uncertainty, leaders may ensure not only immediate crisis management but also long-term organizational health. This chapter also goes into practical leadership techniques for promoting resilience, addressing issues in establishing a resilient workforce and quantifying the impact of leadership on organizational resilience. Finally, it provides insights into the shifting nature of leadership in an increasingly unpredictable world and the efforts leaders must take to guarantee their organizations are prepared for the future.
The Role of Strategic Planning in Resilience and Crisis Management
Authors: Elhamma Azzouz , El-Moumane Rajae
Published: February 2025

Recently, studies on the relationship between strategic planning and crisis management have become a significant focus in management research, especially in light of the numerous crises that have occurred across various fields globally over the past few decades. These studies have shown the importance of strategic planning in crisis management. In this context, our research aims to study the relationship between these two concepts in the Moroccan context. An exploratory qualitative study conducted at a Moroccan public organization reveals a positive relationship between strategic planning and crisis management. This study also shows that coordination, decision-making methods, qualifications, and skills of personnel in the fields of strategy and crisis management significantly impact resilience and successful crisis management.
AI-Driven Personalized Nutrition Apps and Platforms for Enhanced Diet and Wellness
Authors: Prasad Gajendra , Padhiary Mrutyunjay , Hoque Azmirul , Kumar Kundan
Published: February 2025

Health is essential for general well-being and productivity, and in order to properly meet dietary needs and prevent lifestyle-related disorders, creative solutions such as personalized nutrition applications are required. Nutrition apps driven by artificial intelligence (AI) provide individualized nutritional and health solutions. These applications track dietary intake, physical activity, and health parameters using data-driven insights, sophisticated algorithms, and user-centric design. Through gamification, voice assistants, and chatbots, AI promotes customer involvement. In addition to encouraging preventative healthcare, these systems can aid in the prevention of obesity, malnutrition, and chronic diseases. However, there are still obstacles such as data privacy, algorithmic bias, legal concerns, and validation of nutrition databases. For precise and dependable answers, cooperation between AI engineers, nutritionists, and medical specialists is essential.
Advancing Equitable Green Innovation Through Data Analytics Strategies and Insights
Authors: Antonyraj Vijay Arpudaraj
Published: February 2025

Equitable green innovation has emerged as a critical pathway for achieving sustainable development while ensuring inclusivity and fairness in resource distribution. This chapter explores the transformative role of data analytics in driving equitable green innovation across industries and supply chains. By leveraging advanced analytical tools and techniques, organizations can identify inefficiencies, optimize resource utilization, and implement environmentally friendly practices that promote equity. The chapter delves into key areas such as predictive analytics for sustainable decision-making, optimization algorithms for resource management, and real-time monitoring to ensure transparency and accountability. Furthermore, it addresses challenges like data bias, privacy concerns, and the digital divide, offering practical solutions to mitigate these issues. Case studies of successful implementations highlight the potential of data analytics to foster innovation that is both green and equitable. The chapter concludes with a discussion on future opportunities, emphasizing the need for collaborative efforts and technological advancements to scale equitable green innovation globally.
Environmental Responsibility and CSR Using Green Management Techniques
Authors: Vashist Shivani , Mohsin Farhat , Srivastava Nandini , Shukla Sunita , Singh Ritika
Published: February 2025

This research examines how North American professional sports clubs use Corporate Social Responsibility (CSR) to achieve environmental sustainability. Discovering the internal and external factors that motivate these companies to prioritize environmental stewardship is crucial. It highlights the fact that these approaches are only employed in competitive sports. Structured equation modeling (SEM) was used to examine the links between total quality management (TQM), green performance, and corporate social responsibility. For the study endeavor, NBA, NFL, MLB, NHL, and MLS executives were surveyed and interviewed. Notable examples show how incorporating environmentally friendly practices into organizational structures may boost a company's competitiveness and customer loyalty.
Green HRM
Authors: Sharma Suprina , Aggarwal Madhuri , Pattar Manu , Madaan Vandana , Arora Shreya
Published: February 2025

This study analyzes how Green HRM practices affect a company's long-term profitability and employee engagement. Sustainability is integrated into company culture via green HRM. Green performance management, sustainable training, and recruiting are examples. The above are green HRM approaches. These methods are helping firms meet environmental obligations as they become more ecologically concerned. Mixed-methods research allowed us to examine qualitative and quantitative data. The qualitative data was collected via interviews with employees at many organizations, while the quantitative data was collected from questionnaires. Green Human Resource Management clearly improves environmental performance and employee engagement. Data presentation proves this. Personality factors like conscientiousness and good affect moderate the relationship between employee engagement and green HRM. These attributes promote a happier mood.
Leveraging Machine Learning for Equitable Green Innovation
Authors: Janakiraman Anantharaman
Published: February 2025

This chapter explores the intersection of machine learning (ML) and equitable green innovation, emphasizing how advanced computational methods can drive sustainable solutions while ensuring fairness and inclusivity. It examines the role of ML in optimizing environmental practices, from energy efficiency to resource management, while addressing the social and economic disparities that often accompany environmental initiatives. By integrating ML techniques into green technologies, the chapter highlights how these innovations can be designed and implemented to benefit marginalized communities, reduce inequalities, and promote a just transition to a greener economy. Through case studies and theoretical insights, the chapter provides a framework for fostering both technological and social sustainability.
Gastric cancer diagnosis and prevention: Detecting precancerous at community level
Authors: Kotelevets Sergey M , Chukov Sergey Z
Published: February 2025

The problem of gastric cancer (GC) prevention remains relevant for a long time. Various methods of population serological screening of atrophic gastritis and precancerous changes in the gastric mucosa have been created at present. Modern endoscopic and morphological methods of verification of the diagnosis of precancerous diseases and changes in the gastric mucosa have been introduced into the practice of gastroenterologists and oncologists. GC risk stratification systems allow the formation of risk groups that require population screening. Practical hints for population serological screening of atrophic gastritis, endoscopic and morphological verification of precancerous changes and diseases of the stomach recommend using it: When developing state programs for the prevention of stomach cancer; when implementing preventive measures for stomach cancer by doctors of all specialties; the authors also offer the possibility of use by anyone over the age of 40, provided that they seek methodological help from their doctor; in the work of health schools in any medical and preventive institutions. The use of an assessment system of certain risk factor signatures with prognostic value would add significant assistance to preventive measures against GC.
Bridging the gap: The role of technological advances in shaping gastrointestinal oncological outcomes
Authors: Rama Nuno J G , Sousa Inês
Published: February 2025

Gastrointestinal (GI) cancers are highly prevalent and considered a major global health challenge. Their approach has undergone a remarkable transformation over the past years due to the development of new technologies that enabled better outcomes regarding their diagnosis and management. These include artificial intelligence, robotics, next-generation sequencing and personalized medicine. Nonetheless, the integration of these advances into everyday clinical practice remains complex and challenging as we are still trying to figure out if these innovations tangibly improve oncological outcomes or if the current state of art should remain as the gold standard for the treatment of these patients. Additionally, there are also some issues regarding ethical subjects, data privacy, finances and governance. Precision surgery concept has evolved considerably over the past decades, especially for oncological patients. It aims to customize medical treatments and to operate on those patients who most likely will benefit from a specific surgical procedure. In the future, to improve GI oncological outcomes, a delicate balance between technological advances adoption and evidence-based care should be chased. As we move forward, the question will be to harness the power of innovation while keeping up the highest standards of patient care.
Traditional Chinese medicine and modern technology: Network pharmacology and omics sequencing in gastric cancer
Authors: Gemmell Jessica Shapiro , Lucke-Wold Brandon
Published: February 2025

In this editorial, we comment on the article by Micucci et al published in the recent issue. We focus on the heterogenous nature of gastric cancer (GC) and the potential benefits of integrating traditional Chinese medicine (TCM) with the modern technology of network pharmacology (NP) and omics sequencing. GC is a heterogenous disease, as it incorporates several biochemical pathways that contribute to pathogenesis. TCM acknowledges the multifactorial, heterogenous nature of disease and utilizes an integrative approach to medicine. NP, a modern philosophy within drug development, integrates traditional knowledge of nutraceuticals and modern technologies to address the complex interactions of pathways within the body. Omics technologies, which is at the core of precision medicine, has allowed for this newfound principle of drug development. Metabolic pathways are better distinguished, leading to more targeted drug development. However, the use of omics technology needs to be employed to better characterize the subtypes of GC. This will allow TCM’s use of nutraceuticals in the application of NP to better target metabolic pathways that may aid in the prevention of GC as well as enhance treatment.
New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer
Authors: Shang-Guan Xin-Chang , Zhang Jun-Rong , Lin Chao-Nan , Chen Shuai , Wei Yong , Chen Wen-Xuan , Pan Lin , Huang Li-Qin , Zheng Shao-Hua , Chen Xian-Qiang
Published: February 2025

BACKGROUND

The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer (OCRC). The existing assessment still relies on the colorectal obstruction scoring system (CROSS) which is based on a comprehensive analysis of patients’ complaints and eating conditions. The data collection relies on subjective descriptions and lacks objective parameters. Therefore, a scoring system for the evaluation of computed tomography-based obstructive degree (CTOD) is urgently required for OCRC.

AIM

To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term prognosis.

METHODS

Of 173 patients were enrolled. CTOD was obtained using k-means, the ratio of proximal to distal obstruction, and the proportion of nonparenchymal areas at the site of obstruction. CTOD was integrated with the CROSS to analyze the effect of emergency intervention on complications. Short-term and long-term outcomes were compared between the groups.

RESULTS

CTOD severe obstruction (CTOD grade 3) was an independent risk factor [odds ratio (OR) = 3.390, 95% confidence interval (CI): 1.340-8.570, P = 0.010] via multivariate analysis of short-term outcomes, while CROSS grade was not. In the CTOD-CROSS grade system, for the non-severe obstructive (CTOD 1-2 to CROSS 1-4) group, the complication rate of emergency interventions was significantly higher than that of non-emergency interventions (71.4% vs 41.8%, P = 0.040). The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group (35.7% vs 8.9%, P = 0.020). However, CTOD grade was not an independent risk factor of overall survival and progression-free survival.

CONCLUSION

CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.
Risk of progression to high-grade intraepithelial neoplasia and gastric cancer: A multi-center prospective study in Anhui Province, China
Authors: Liu Ying-Ling , Liu Jie , Wang Ye-Tao
Published: February 2025

BACKGROUND

Gastric cancer is one of the most common cancers worldwide, especially in East Asia.

AIM

To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia (LGIN) in the gastric mucosa and provide valuable guidance for improving treatment efficacy.

METHODS

A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included. Among them, 296 patients were followed up with endoscopic and biopsy pathology. Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.

RESULTS

The distribution sites of LGIN among the 357 patients were as follows: Gastric antrum (54.6%), gastric cardia (24.1%), gastric angulus (8.7%), gastric body (4.8%), gastric fundus (4.8%), and multiple sites (3.1%). Additionally, of the 357 patients with LGIN, 112 (31.4%) developed ulceration and 59 (16.5%) experienced gastric polyps. Furthermore, 231 of the 357 (64.71%) patients with LGIN tested positive for Helicobacter pylori (H. pylori ) infection. The H. pylori infection rates of the patients with LGIN with accompanying atrophy, intestinal metaplasia, and gastric ulcer were 51.95%, 59.31%, and 28.57%, respectively. Multivariate logistic regression analysis showed that age ≥ 60 years [odds ratio (OR) = 3.063, 95% confidence interval (CI): 1.351-6.945, P = 0.007], H. pylori infection (OR = 3.560, 95%CI: 1.158-10.949, P = 0.027), multiple locations (OR = 10.136, 95%CI: 2.045-50.237, P = 0.005), lesion size ≥ 2 cm (OR = 3.921, 95%CI: 1.664-9.237, P = 0.002), and gastric ulcer (OR = 2.730, 95%CI: 1.197-6.223, P = 0.017) were predictive factors for LGIN progression.

CONCLUSION

LGIN progression is closely related to age, H. pylori positivity, multiple locations, lesion size ≥ 2 cm, and gastric ulcer. Thus, actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.
Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma
Authors: Chen Xia , Liu Hai-Yan , Zhou Wu-Bi , Zhang Li-Li , Huang Jian , Bao Da-Wei
Published: February 2025

BACKGROUND

Esophageal squamous-cell carcinoma (ESCC) is a highly aggressive cancer, predominantly affecting populations in Eastern Asia and parts of Africa. Its pathogenesis is influenced by both genetic and environmental factors. Despite recent therapeutic advances, survival rates remain dismal, underscoring an urgent need for novel therapeutic targets.

AIM

To investigate the role of hypoxia-inducible factor 1-alpha (HIF1A) in the progression of ESCC and its impact on the metabolic enzyme lactate dehydrogenase A (LDHA), which is crucial for the glycolytic pathway in hypoxic tumor environments.

METHODS

Utilizing transcriptomic data from multiple public databases, we analyzed differential gene expression and conducted gene ontology and transcription factor network analyses. The regulatory impact of HIF1A on LDHA was specifically examined through integrative analysis with HIF1A ChIP-seq data and confirmed via siRNA-mediated knockdown experiments in ESCC cell lines.

RESULTS

Our findings reveal a significant upregulation of HIF1A in ESCC tissues, associated with poor prognosis. HIF1A directly regulates LDHA, enhancing glycolysis under hypoxic conditions and contributing to tumor aggressiveness. Knockdown of HIF1A in cell lines not only reduced LDHA expression but also altered key pathways related to cell cycle and apoptosis.

CONCLUSION

The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target, underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.
Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition
Authors: Qian Wei , Xu Chong-Yi , Hong Wei , Li Zhe-Ming , Xu Dao-Gun
Published: February 2025

BACKGROUND

Activation of the epithelial-mesenchymal transition (EMT), a pivotal process in tumor metastasis and evasion, as well as the NLRP3 inflammasome, both promote colorectal cancer (CRC) progression. Recent studies have shown that Transmembrane protein 176B (TMEM176B) regulates NLRP3 and promotes CRC malignant phenotypes.

AIM

To investigate the role of TMEM176B in modulating NLRP3 inflammasome and its implications on EMT and tumor progression in CRC.

METHODS

CRC in situ mouse and co-cultured cell models were established using CT26 cells, BALB/c mice, and primary cultured mouse natural killer (NK) cells. Short hairpin RNA knocked down TMEM176B and NLRP3 expression in CT26 cells. Fluorescence imaging, Terminal deoxynucleotidyl transferase dUTP nick end labeling assays, immunohistochemistry staining, flow cytometry, and molecular assays were used to investigate the effects of TMEM176B knockdown on the NLRP3 inflammasome in NK cells to assess tumor metastasis, apoptosis, and EMT indicators.

RESULTS

Silencing TMEM176B in CRC mice significantly reduced tumor metastasis, proliferation, and EMT, while activating apoptosis, NLRP3 inflammasome, and NK cell activity. Furthermore, silencing TMEM176B in co-cultured cell models inhibited cell migration and invasion, and promoted apoptosis. The interference of NLRP3 reversed these effects by modulating key proteins such as phosphorylated nuclear factor kappa B subunit 1 p65, matrix metallopeptidase 9, and transforming growth factor-β.

CONCLUSION

This study highlights the critical role of TMEM176B/NLRP3 in CRC progression and provides a basis for targeting this axis as a novel therapeutic approach to manage CRC progression and metastasis.
Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors
Authors: Li Hai-Tao , Du Yun-Yun , Huang Zhen , Li Jin-Jin , Zhang Jun
Published: February 2025

BACKGROUND

For patients with advanced gastrointestinal stromal tumors (GISTs) carrying the c-kit exon 11 mutation, imatinib (IM) at a standard dosage of 400 mg per day is the preferred first-line treatment. In cases where treatment with IM fails, there is an urgent need for a more precise assessment method to determine whether to switch therapies or escalate the IM dosage. This approach will enhance clinical decision-making and optimize patient outcomes.

AIM

To investigate IM plasma concentration’s role in second-line treatment decisions for c-kit 11-mutated advanced GISTs post-IM failure.

METHODS

Patients with advanced GIST harboring c-kit 11 mutation who experienced failure with IM 400 mg per day as first-line treatment at our hospital were retrospectively analyzed. Patients were categorized into a low plasma (LP) concentration group (LP group, < 1100 ng/mL) and high plasma (HP) concentration group (HP group, ≥ 1100 ng/mL). Each group was further subdivided into Group A (dose-escalation group) and Group B (drug-switch group). Baseline characteristics were compared and Kaplan-Meier curves were used to analyze the survival of patients.

RESULTS

Seventy-five patients were included in the analysis. For the LP group (n = 28), Group A (n = 14) had longer overall survival (OS) than Group B (n = 14) (P = 0.02). No differences were observed between the two subgroups in disease control rate (DCR), objective response rate, and progression-free survival (PFS) (P > 0.05). For the HP group (n = 47), Group B (n = 18) had a higher DCR and longer PFS than Group A (n = 29) (P = 0.008 and P = 0.03, respectively). No difference in OS was observed between the two subgroups (P > 0.05).

CONCLUSION

Increasing IM dosage for c-kit 11-mutated advanced GISTs post-IM failure may prolong OS if plasma concentration is < 1100 ng/mL. Switching tyrosine kinase inhibitors may improve DCR and PFS if ≥ 1100 ng/mL.
Current research status and future directions of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma
Authors: Chisthi Meer M
Published: February 2025

The rapid evolution of systemic therapies for hepatocellular carcinoma (HCC), one of the most common types of liver cancer, has attracted significant attention especially to hepatic arterial infusion chemotherapy (HAIC) as a highly promising treatment approach. This method, which delivers chemotherapy directly into the liver's arterial supply, is designed to maximize the concentration of anti-cancer drugs at the tumor site while minimizing systemic side effects. Despite the potential and the encouraging results observed in various studies, HAIC has not yet achieved widespread acceptance and utilization. Sorafenib is a widely used systemic therapy that targets multiple pathways involved in tumor growth and angiogenesis, while transarterial chemoembolization (TACE) is a locoregional therapy that combines arterial embolization with chemotherapy. These treatments have been the mainstay of HCC management, yet they have limitations that HAIC may potentially overcome. This article specifically comments on the network meta-analysis that examined the current research status of HAIC, highlighting its effectiveness and safety profile in comparison to established standard treatments such as Sorafenib and TACE. Through an extensive review of existing studies, the authors conclude that patients receiving HAIC often experience better survival rates and longer periods without disease progression compared to those receiving Sorafenib or TACE.
Cystic artery embolism after transarterial chemoembolization for hepatocellular carcinoma: A case report and review of the literature
Authors: Chen Yi-Fan , Lin Zhen-Yi , Chen Lin-Tao , Zhang Yu , Du Zhao-Qing
Published: February 2025

BACKGROUND

Acute cholecystitis due to unintended cystic artery embolism is an uncommon and mostly self-limiting complication after transarterial chemoembolization procedure for treatment of hepatocellular carcinoma. Usually, conservative management is sufficient for complete recovery of patients who develop this complication. If conservative treatment is ineffective, urgent surgical intervention may be required to prevent the progression of complications.

CASE SUMMARY

This article reports a rare and serious case of acute cholecystitis complicated by gallbladder necrosis and biliary peritonitis, which was initially treated conservatively but eventually necessitated emergency laparotomy. The patient initially presented with equivocal symptoms of fever and upper abdominal pain and distention, which worsened at the two weeks mark along with emergence of signs of peritonitis. This was managed by emergency laparotomy and cholecystostomy, allowing rapid symptom relief. The patient ultimately discharged and succumbed to advanced liver cancer 11 months after diagnosis.

CONCLUSION

After cholecystostomy, the patient showed symptom relief and was discharged, surviving 11 months post-stage IIIB liver cancer diagnosis.
Efectos adversos de la vacunación Covid-19 en trabajadores de 4 hospitales en España
Authors: Martinez Garate Irene , Valdés del Olmo Laura , Martínez Castellanos José Antonio , Cátedra Caramé Claudia
Published: February 2025

Introducción: Tras decretarse la pandemia mundial por el virus SARS-CoV-2 en el año 2020, los diferentes laboratorios farmacéuticos comenzaron a desarrollar las vacunas frente a este virus utilizando RNA modificado para ello. El objetivo de este estudio es comparar los efectos adversos manifestados tras la administración de las vacunas de Pfizer y Moderna contra la infección por SARS-CoV-2 por la población trabajadora de los Hospitales Universitarios de Donostia, Galdakao, Cruces y Severo Ochoa. 
Método: Estudio de cohortes retrospectivo. Se procedió a la recogida de datos a través de una encuesta online, realizando posteriormente el análisis de los mismos utilizando el programa informático STATA. 
Resultados: Los trabajadores vacunados con Moderna han reportado más efectos adversos que aquellos vacunados con Pfizer. Se observó un mayor número de notificaciones tras la administración de la segunda dosis de la vacuna de Moderna para la mayoría de los efectos adversos recogidos en la encuesta. 
Conclusiones: Los trabajadores vacunados con Moderna han presentado significativamente más efectos adversos que los vacunados con Pfizer, aunque esta diferencia requiere estudios adicionales para confirmar resultados y determinar causas.
Public discourse and comparative constitutional law: a research agenda
Authors: Bui Ngoc Son
Published: February 2025

Mainstream comparative constitutional law focuses mainly on state institutions. Yet, in different parts of the world, ordinary citizens engage in public discourse on constitutional questions, which is both shaped by and shapes constitutional law. Nevertheless, public discourse lacks a systematic attention in comparative constitutional law. This article seeks to broaden the scope of comparative constitutional law by laying down a framework for comparative study of public constitutional discourse defined as citizen’s deployment of vocal and written language to exchange and contest constitutional ideas in the public sphere. The framework includes these aspects of public constitutional discourse: elements (objects, subjects, spaces, and actions); framing strategies (historical, synchronic, and comparative); functions (assertive, critical, interpretive, and normative); and consequence (institutional, ideational, and functional). Finally, the article considers some theoretical implications and methodological questions.
Will 2025 be the year of the agent? A primer for competition practitioners on the next wave of AI innovation
Authors: Hunt Stefan , Chissell Emily , Mawar Aman
Published: February 2025

AI innovation is increasingly focusing on the development and utilization of AI agents: systems that gather information, make decisions and take actions with some degree of autonomy. Agents represent a natural evolution from AI that generates outputs following user commands, such as ChatGPT, to AI that plays a much more active role by completing tasks. For example, in the future, a consumer AI agent might book and pay for a holiday or decide which groceries to order. Tech luminaries believe agents will make AI truly transformative, and tech firms and investors have been investing in AI agents as they look to monetize AI.

Given the emerging focus on agents, it will not be long before competition agencies take a closer look to assess any concerns against benefits. This article previews some of the likely debates to come. Many possible issues that could be raised appear analogous to those of other digital markets, such as self-preferencing, pre-installation and defaults, market tipping and ecosystem effects. But agencies may also raise new or potentially more challenging issues about AI agents, ranging from access to hardware/software, conflict of interests, use of personalized data, to a lack of transparency. Equally, agents might trigger more seismic changes in the competitive landscape.
MORPHO-FUNCTIONAL ADAPTATIONS OF THE TIGER SKULL (PANTHERA TIGRIS) IN RELATION TO FORCEFUL BITING
Authors: CHERSUNARU Alexandra-Andreea , SPATARU Mihaela Claudia , SPATARU Constantin
Published: February 2025

The anatomical peculiarities of the tiger’s skull reflect the ecological and behavioural needs of this predator. The study aims to observe the morphological adaptations that grant it exceptional hunting and survival abilities. The anatomical study was conducted on the skulls of two adult male tigers. The tiger’s skull is wide and rounded, providing a robust base for the attachment of masticatory muscles, which is essential for powerful bites. The sagittal crest, a bony prominence located on the upper part of the skull, serves as an attachment point for the temporal muscles. A distinct process is present on the maxillary tubercle, from which a strong tendon of the masseter muscle originates. The nasal bones are elongated, extending beyond the frontal processes of the maxillae, while the frontal area is elevated in the region of the postorbital processes. The anterior nasal opening is narrow, and the lower margin of the mandible is typically concave, with a prominent mental process. The front part of the mandibular symphysis is concave. Compared to other large felines, tigers have a more rounded skull and a downward-sloping dorsal surface. The tiger’s skull exhibits remarkable morpho-functional adaptations, such as a robust bony head, a prominent sagittal crest, a strong mandible, and well-developed insertions for masticatory muscles. These features are essential for their predatory lifestyle, allowing them to capture and control large prey efficiently.
PENGARUH KOMPENSASI DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PADA KOPERASI WARGA SEMEN GRESIK TANGERANG
Authors: Huzaifah Azmi , Erica Denny
Published: February 2025

Manajemen sumber daya  manusia sangat penting dilakukan untuk memastikan karyawan memberikan kontribusi maksimal sesuai dengan visi dan misi yang dimiliki dalam mewujudkan tujuan perusahaan secara efektif dan efesien. Dalam penelitian ini penulis memiliki kesempatan untuk melakukan penelitian pada Koperasi Warga Semen Gresik Tangerang. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi kinerja karyawan, dengan fokus pada pengaruh kompensasi dan disiplin kerja. Penelitian ini menggunakan pendekatan kuantitatif dan menggunakan data primer yang diperoleh dengan penyebaran kuesioner ke 30 karyawan. Teknik analisis data yang digunakan dalam penelitian ini adalah regresi linear berganda, yang dioperasikan melalui program SPSS. Hasil penelitian ini menunjukkan bahwa kompensasi tidak berpengaruh terhadap kinerja karyawan karena diperoleh t hitung 1.766 < t tabel 2,052 dengan sig. sebesar 0,89 > 0,05, disiplin kerja berpengaruh terhadap kinerja karyawan karena  diperoleh t hitung sebesar 5,290 > t tabel 2,052 dengan nilai sig. 0,000 < 0,05. Sedangkan kompensasi dan disiplin kerja secara simultan berpengaruh terhadap kinerja karyawan, karena diperoleh  nilai f hitung sebesar 43,079 > f tabel  3,35 dengan nilai sig. 0,000 < 0,05.