bluuebunny/crossref_metadata_2025 huggingface dataset:
Olfactory Sensing and Navigation in Turbulent Environments
Authors: Reddy Gautam , Murthy Venkatesh N. , Vergassola Massimo
Published: November 2021

Fluid turbulence is a double-edged sword for the navigation of macroscopic animals, such as birds, insects, and rodents. On the one hand, turbulence enables pheromone communication among mates and the possibility of locating food by their odors from long distances. Molecular diffusion would indeed be unable to spread odors over relevant distances in natural conditions. On the other hand, turbulent flows are hard to predict, and learning effective maneuvers to navigate them is challenging, as we discuss in this review. We first provide a summary of the olfactory organs that sense airborne or surface-bound odors, as well as the computational tasks that animals face when extracting information useful for navigation from an olfactory signal. A compendium of the dynamics of turbulent transport emphasizes those aspects that directly impact animals’ behavior. The state of the art on navigational strategies is discussed, followed by a concluding section dedicated to future challenges in the field.
Discrete Latent Variable Models
Authors: Bartolucci Francesco , Pandolfi Silvia , Pennoni Fulvia
Published: November 2021

We review the discrete latent variable approach, which is very popular in statistics and related fields. It allows us to formulate interpretable and flexible models that can be used to analyze complex datasets in the presence of articulated dependence structures among variables. Specific models including discrete latent variables are illustrated, such as finite mixture, latent class, hidden Markov, and stochastic block models. Algorithms for maximum likelihood and Bayesian estimation of these models are reviewed, focusing, in particular, on the expectation–maximization algorithm and the Markov chain Monte Carlo method with data augmentation. Model selection, particularly concerning the number of support points of the latent distribution, is discussed. The approach is illustrated by summarizing applications available in the literature; a brief review of the main software packages to handle discrete latent variable models is also provided. Finally, some possible developments in this literature are suggested.
Embryonal Rhabdomyosarcoma with Posttherapy Cytodifferentiation and Aggressive Clinical Course
Authors: Jeyaraju Maniraj , Macatangay Regina Ann , Munchel Ashley Taylor-King , York Teresa Anne , Montgomery Elizabeth A. , Kallen Michael E.
Published: November 2021

Rhabdomyosarcoma is the most common soft tissue sarcoma in children and adolescents. Embryonal rhabdomyosarcoma (ERMS), its most common subtype, is a malignant soft tissue tumor with morphologic and immunophenotypic features of embryonic skeletal muscle. The histologic findings in ERMS typically include a range of differentiation in rhabdomyoblasts from primitive to terminally differentiated forms, and the latter become more prominent after chemotherapy-induced cytodifferentiation. Several reports have shown therapy-related cytodifferentiation to portend a good prognosis in ERMS. We discuss the case of a pediatric patient who presented with ERMS of the orbit. Although her tumor showed extensive posttreatment cytodifferentiation and several other good prognostic clinicopathologic factors, it pursued an aggressive course, resulting in early metastasis and death. This case represents an unusual course and may be instructive as to the clinicopathologic features impacting prognostication, and ultimately the biology, of this aggressive family of tumors.
An Experimental and Algorithm Research on the Influence of OTO Teaching Mode on College Students' PE Learning Interest Based on Cloud Computing
Authors: Wu Shijun , Dai Jianghong , Yang Jiujiu
Published: November 2021

Algorithm is a step of problem-solving, and algorithm can be defined as any special method for solving a certain type of problem. In computer science, algorithms are described in computer algorithm language and represent accurate and effective methods for solving a class of problems with computers. In order to verify the role of the OTO teaching mode from the perspective of cultivating learning interest and to provide a practical basis for the reform of physical education in colleges and universities, 107 second-year physical education majors in a common university were selected as experimental subjects and divided into an experimental group and a control group, and the two groups were intervened through a 16-week experiment. Multivariate covariance was used to analyze the influence of two teaching modes on college students' interest in sports learning. After excluding factors such as student gender, physical exercise behavior stage, football learning experience, and physical health, the groups have statistical significance in the four dimensions of positivity, skill learning, extracurricular activities, and negativity in sports learning interest. However, there is no significant difference in the influence of sports attention on sports learning interest. The research proves that the application of OTO teaching mode is conducive to promoting students' learning positivity, technical learning, and extracurricular activities and alleviating students' negative learning emotions. The degree of attention to sports in the interest of sports learning is not very significant. It is suggested that colleges and universities adopt the OTO teaching mode in the teaching of general football courses.
A Novel Method of Clinical Nursing under the Medical Internet of Things Technology
Authors: Ou Tingting , Cai Xuehua , Wang Meichun , Guo Feirong , Wu Biyu
Published: November 2021

Internet of things technology began to spread to all industries of our lives; the application of medical internet of things in many hospitals highlighted its advantages and brought a lot of convenience to patients and medical staff. With the continuous progress of China’s medical reform and the continuous improvement of patients’ requirements for medical service quality, this paper discusses the application of medical internet of things in clinical nursing in ward, and the basic information collection, infusion, and mobile nursing were discussed and studied. Through the parallel control study of the laboratory itself, this paper evaluates whether the two different clinical measurement methods of medical internet of things technology and traditional technology are consistent in body temperature, pulse, respiration, and blood oxygen saturation. At the same time, it also deeply studies the value and advantages of internet of things technology in the application of other monitoring indicators in clinical nursing and analyses the problems in its application. The experimental data show that the two measurement methods with different principles can be completely replaced in clinical application, and the time efficiency of the new clinical nursing method under the medical internet of things technology in mapping body temperature, pulse, and respiration has been improved by 76.20% and 72.02%, respectively, surpassing the traditional information technology and realizing the intelligent, automatic, and standardized data acquisition method. It ensures the authenticity of data and the real-time of information flow and meets the needs of resource sharing and medical regional interconnection.
Design and Implementation of English Listening Teaching Based on a Wireless Communication Microprocessor and Virtual Environment
Authors: Liu Li
Published: November 2021

This paper presents an in‐depth analysis and research on teaching English listening through a wireless communication microprocessor combined with a virtual environment and designs and implements an English listening teaching experiment. Based on an in‐depth understanding of wireless communication algorithms, this thesis extends the instruction set based on the general‐purpose compact instruction set computer architecture (RISC) for common operations in wireless communication algorithms, adding new instructions such as multiplication and addition and bit inversion. The microprocessor has an increase in the number of execution clocks for wireless algorithm processing. The processor is extended with an interrupt interface to facilitate information interaction between the processor and the external environment to achieve coordinated work between the processor and the accelerator and to further enhance the speed of digital signal processing through the introduction of the accelerator. An overview and comparison of the status of domestic and foreign research are presented in the vein of VR teaching and the overall development of English teaching. Then, the problems and hypotheses to be explored in this study are presented, and several types of research methods used to explore the solutions to the problems are introduced. The results of the two classroom formats were compared, and specific performance data were obtained. The analysis of the results showed that the students in the VR scenario teaching group made greater progress in vocabulary judgments, complementary dialogues, and Chinese to English translation, with a 43% merit rate and a 100% pass rate in English for the whole group. The real‐life scenarios created through VR technology greatly increased students’ interest in learning and significantly improved the effectiveness of classroom teaching. The development trend of education informatization is towards virtualization and intelligence, and the application of VR to the process of education teaching is of great significance to promote the modernization of secondary education informatization.
SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia
Authors: Chen Zhe , Zhou Shufen , Li Jianyun , Li Hui , Huang Can , Guo Qin , Zhang Tiantian , Yang Bingya , Tu Chuanqing , Guo Chengshan
Published: November 2021

B cells play a central role in the pathogenesis of immune thrombocytopenia (ITP) by participating in humoral immunity. Meanwhile, regulatory B cells (Bregs), one subset of B cells, express negative regulatory effect on ITP. Mesenchymal stem cells (MSCs) have been demonstrated in the ability to induce immunosuppression, and stromal cell-derived factor-1α (SDF-1α) plays an important role in the migration and survival of MSCs. To investigate the mechanism of SDF-1α in controlling umbilical cord-derived MSCs (UC-MSCs) in inducing regulatory B cell differentiation of patients with ITP, we reconfirmed that SDF-1α promotes the proliferation of MSCs at the low doses of 0.05 μg/mL and 0.1 μg/mL but inhibits the proliferation and promotes the apoptosis of UC-MSCs at the high doses 0.5 μg/mL and 1 μg/mL; when UC-MSCs are cocultured with SDF-1α at 0.1 μg/mL, the decreased proportion of CD19+/CD24hi/CD38hi cells and IL-10-producing B cells (B 10 cell), considered as the Breg subset from ITP significantly enhanced, and the content of IL-10 in the supernatant is also obviously increased. The proportion of Bregs and the IL-10 secretion could be further promoted by the UC-MSCs treated with 0.1 μg/mL SDF-1α, which could also promote the miRNA-133 expression of UC-MSCs in an exosome-dependent manner; moreover, while the UC-MSCs were transfected with the miR-133 inhibitor, the proportion of induced Bregs decreased obviously when cocultured with peripheral blood mononuclear cells (PBMCs) of ITP. We conclude that UC-MSCs could effectively enhance the decreased proportion of Bregs from ITP; at appropriate concentrations, SDF-1α may promote the proliferating and survival ability of UC-MSCs and improve the production of Bregs induced by UC-MSCs through controlling miRNA-133 expression in the exosomes.
Study of

B

s

⟶
ϕ

ℓ

+

ℓ

−

Decays in the PQCD Factorization Approach with Lattice QCD Input
Authors: Jin Su-Ping , Xiao Zhen-Jun
Published: November 2021

In this paper, we studied systematically the semileptonic decays

B

s

⟶
ϕ

l

+

l

−

with

l

−

=

e

−

,

μ

−

,

τ

−

by using the perturbative QCD (PQCD) and the “PQCD+Lattice” factorization approach, respectively. We first evaluated all relevant form factors

F

i

q

2

in the low-

q

2

region using the PQCD approach, and we also took the available lattice QCD results at the high-

q

2

region as additional input to improve the extrapolation of

F

i

q

2

from the low-

q

2

region to the endpoint

q

max

2

. We then calculated the branching ratios and many other physical observables

A

FB

l

,

F

L

ϕ

,

S

3
,
4
,
7

, and

A

5
,
6
,
8
,
9

and the clean angular observables

P

1
,
2
,
3

and

P

4
,
5
,
6
,
8

′

. From our studies, we find the following points: (a) the PQCD and “PQCD+Lattice” predictions of

B

B

s

⟶
ϕ

μ

+

μ

−

are about

7
×
1

0

−
7

, which agree well with the LHCb measured values and the QCD sum rule prediction within still large errors; (b) we defined and calculated the ratios of the branching ratios

R

ϕ

e
μ

and

R

ϕ

μ
τ

; (c) the PQCD and “PQCD+Lattice” predictions of the longitudinal polarization

F

L

, the CP-averaged angular coefficients

S

3
,
4
,
7

, and the CP asymmetry angular coefficients

A

5
,
6
,
8
,
9

agree with the LHCb measurements in all considered bins within the still large experimental errors; and (d) for those currently still unknown observables

R

ϕ

e
μ

,

R

ϕ

μ
τ

,

A

FB

l

,

P

1
,
2
,
3

, and

P

4
,
5
,
6
,
8

′

, we suggest LHCb and Belle-II Collaboration to measure them in their experiments.
Diagnostic Value of Serum Heparin Binding Protein, Blood Lactic Acid Combined with hs-CRP in Sepsis and Its Relationship with Prognosis
Authors: Ma Hongsong , Liu Huasheng , Wu Changyu , Huang Lieping
Published: November 2021

Objective. To explore the diagnostic value of serum heparin binding protein (HBP), blood lactic acid (Lac) combined with high-sensitivity C- reactive protein (hs-CRP) in sepsis and its relationship with prognosis. Methods. The clinical data of 127 patients with sepsis from March 2019 to March 2021 in our hospital were retrospectively analyzed. 120 outpatients undergoing physical examination in the same period in our hospital were selected as the control group. According to the severity of the disease, 127 sepsis patients were divided into the mild sepsis group (n = 45), severe sepsis group (n = 53), and septic shock group (n = 29). According to the clinical prognosis, the patients were divided into the survival group (n = 96) and death group (n = 31). Serum HBP, Lac, and hs-CRP levels were measured in all subjects. The ROC curves of the subjects were drawn to analyze the predictive value of serum HBP, Lac, and hs-CRP for the prognosis of sepsis patients. Results. The levels of serum HBP, Lac, and hs-CRP in the sepsis group were higher than those in the control group (

P
<
0.05

). With the increase of the severity of sepsis, serum HBP, Lac, and hs-CRP levels of patients gradually increased (

P
<
0.05

). The levels of serum HBP, Lac, and hs-CRP in the death group were higher than those in the survival group (

P
<
0.05

). The AUC of serum HBP, Lac, and hs-CRP for predicting the prognosis of sepsis patients was 0.858 (95% CI: 0.763–0.953), 0.694 (95% CI: 0.589–0.799), and 0.843 (95% CI: 0.759–0.927). The AUC of serum HBP, Lac combined with hs-CRP for predicting the prognosis of sepsis patients was 0.961 (95% CI: 0.000–1.000). Conclusion. The levels of serum HBP, Lac, and hs-CRP in patients with sepsis were significantly increased and increased with the severity of sepsis. Serum HBP, Lac, and hs-CRP have a good value in predicting the prognosis of patients with sepsis and worthy of clinical application.
Agent-Based Simulators for Empowering Patients in Self-Care Programs Using Mobile Agents with Machine Learning
Authors: Kumar Swarn Avinash , García-Magariño Iván , Nasralla Moustafa M. , Nazir Shah
Published: November 2021

E-health sustainable systems can be optimized by empowering patients in self-care programs through artificial intelligence ecosystems in which both doctors and patients interact in an agile way. This work proposes agent-based simulators as a mechanism for predicting the repercussions of certain self-care programs in certain patients for finding the most appropriate ones. In order to make this easy for both doctors and patients, mobile agents are used to configure an app for each patient, and this app provides the resources to each self-care program. Mobile agents include a machine-learning module for learning which programs are the most appropriate for each patient. This approach is illustrated with two agent-based simulators for respectively reducing negative emotions such as depression and controlling heart rate variability extreme values related to stress. The resulting app was evaluated with a group of users with the Usefulness, Satisfaction and Ease of use (USE) scale and obtained 73% in usefulness, 77% in satisfaction, and 68% in ease of use. This trial is registered with According to the recommendations of the International Committee of Medical Journal Editors (ICMJE), this manuscript states that all experiments have been approved with the ethical committee CEICA from Community of Aragon (Spain) with registration number C.I.PI18/099.
Screening of Active Components and Key Targets of Radix Codonopsis in the Treatment of Gastric Cancer
Authors: Tang Lijun , Chen Jinhui , Yin Jin , Fang Mingli
Published: November 2021

Gastric cancer is the fifth most common cancer type in the world. The incidence and mortality of gastric cancer in China ranks second among malignant tumors in the country. At present, the main treatment method of gastric cancer is still surgical resection combined with chemotherapy. However, chemotherapy drugs will cause serious toxic and side effects on other normal tissues and cells. At the same time, chemotherapy drugs can make patients develop drug resistance and seriously affect the curative effect. By contrast, Chinese medicine has more advantages in the treatment of cancer. Dangshen (Radix Codonopsis), a traditional Chinese medicine, has been proved to be effective for the clinical treatment of gastric cancer. However, due to the complex components of Dangshen, the main active components and pharmacological mechanism for its treatment of gastric cancer are still unclear. In this study, the main active components and pharmacological mechanism of Radix Codonopsis in the treatment of gastric cancer were preliminarily explored based on network pharmacology and molecular docking. We obtained bioactive compounds and targets from Radix Codonopsis from the Chinese Medicine System Pharmacology Database (TCMSP) and constructed the active ingredient-target network of Codonopsis pilosula. We then obtained targets related to gastric cancer from the disease database. The common targets of Radix Codonopsis and gastric cancer were the key target of Radix Codonopsis for the treatment of gastric cancer. Then, we used Metascapedatabase to conduct functional enrichment analysis on the key targets of Radix Codonopsis for the treatment of gastric cancer to clarify the mechanism of Radix Codonopsis for the treatment of gastric cancer. We constructed a network to screen the main bioactive compounds and therapeutic targets, assessed the prognostic value of the main target genes by survival analysis, and finally assessed the binding affinity of the main target genes and main bioactive compounds of Radix Codonopsis for the treatment of gastric cancer by molecular docking. The results showed that the main active compounds of Codonopsis pilosula in treating gastric cancer were luteolin and cryptotanshinone, which played a role in the treatment of gastric cancer through the multitarget and multipathway mechanism.
Application of Bayesian Decision Tree in Hematology Research: Differential Diagnosis of β-Thalassemia Trait from Iron Deficiency Anemia
Authors: Jahangiri Mina , Rahim Fakher , Saki Najmaldin , Saki Malehi Amal
Published: November 2021

Objective. Several discriminating techniques have been proposed to discriminate between β-thalassemia trait (βTT) and iron deficiency anemia (IDA). These discrimination techniques are essential clinically, but they are challenging and typically difficult. This study is the first application of the Bayesian tree-based method for differential diagnosis of βTT from IDA. Method. This cross-sectional study included 907 patients with ages over 18 years old and a mean (±SD) age of

25
±
16.1

with either βTT or IDA. Hematological parameters were measured using a Sysmex KX-21 automated hematology analyzer. Bayesian Logit Treed (BLTREED) and Classification and Regression Trees (CART) were implemented to discriminate βTT from IDA based on the hematological parameters. Results. This study proposes an automatic detection model of beta-thalassemia carriers based on a Bayesian tree-based method. The BLTREED model and CART showed that mean corpuscular volume (MCV) was the main predictor in diagnostic discrimination. According to the test dataset, CART indicated higher sensitivity and negative predictive value than BLTREED for differential diagnosis of βTT from IDA. However, the CART algorithm had a high false-positive rate. Overall, the BLTREED model showed better performance concerning the area under the curve (AUC). Conclusions. The BLTREED model showed excellent diagnostic accuracy for differentiating βTT from IDA. In addition, understanding tree-based methods are easy and do not need statistical experience. Thus, it can help physicians in making the right clinical decision. So, the proposed model could support medical decisions in the differential diagnosis of βTT from IDA to avoid much more expensive, time-consuming laboratory tests, especially in countries with limited recourses or poor health services.
Energy Efficiency Optimization of Massive MIMO Systems Based on the Particle Swarm Optimization Algorithm
Authors: Yang Jing , Zhang Liping , Zhu Chunhua , Guo Xinying , Zhang Jiankang
Published: November 2021

As one of the key technologies in the fifth generation of mobile communications, massive multi‐input multioutput (MIMO) can improve system throughput and transmission reliability. However, if all antennas are used to transmit data, the same number of radiofrequency chains is required, which not only increases the cost of system but also reduces the energy efficiency (EE). To solve these problems, in this paper, we propose an EE optimization based on the particle swarm optimization (PSO) algorithm. First, we consider the base station (BS) antennas and terminal users and analyze their impact on EE in the uplink and downlink of a single‐cell multiuser massive MIMO system. Second, a dynamic power consumption model is used under zero‐forcing processing, and it obtains the expression of EE that is used as the fitness function of the PSO algorithm under perfect and imperfect channel state information (CSI) in single‐cell scenarios and imperfect CSI in multicell scenarios. Finally, the optimal EE value is obtained by updating the global optimal positions of the particles. The simulation results show that compared with the traditional iterative algorithm and artificial bee colony algorithm, the proposed algorithm not only possesses the lowest complexity but also obtains the highest optimal value of EE under the single‐cell perfect CSI scenario. In the single‐cell and multicell scenarios with imperfect CSI, the proposed algorithm is capable of obtaining the same or slightly lower optimal EE value than that of the traditional iterative algorithm, but the running time is at most only 1/12 of that imposed by the iterative algorithm.
Protective Effect of Hyperbaric Oxygen Treatment on Axon Degeneration after Acute Motor Axonal Neuropathy
Authors: Sri Dewi Untari Ni Komang , Kusumastuti Kurnia , Suryokusumo Guritno , Sudiana I Ketut
Published: November 2021

Objectives. Acute motor axonal neuropathy (AMAN) is a disease that leads to acute flaccid paralysis and may result from the binding of antibody and antigen to the spinal cord. The objective of this study is to evaluate the protective effect of hyperbaric oxygen treatment (HBOT) on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit. Axonal degeneration was assessed by evaluating glutathione (GSH) activity, interleukin-1β (IL-1β) expression, and clinical and histopathological features. Methods. Twenty-one New Zealand rabbits were divided into three groups. The treatment group was exposed to 100% oxygen at 2.4 ATA 90 minutes for 10 days at a decompression rate of 2.9 pounds per square inch/minute. GSH level was evaluated using an enzyme-linked immune-sorbent assay. An expression of IL-1β in the spinal cord was determined by immunohistochemistry. Clinical appearances were done by motor scale and body weight. Histological features observed neuronal swelling and inflammatory infiltration in the sagittal lumbar region and the undulation of the longitudinal sciatic nerve. Results. Rabbits exposed to HBO had high GSH activity levels (

p
<
0.05

) but unexpectedly had high IL1β expression (

p
>
0.05

). In addition, the HBO-exposed rabbits had a better degree of undulation, the size of neuronal swelling was smaller, the number of macrophages was higher, and motor function was better than the AMAN model rabbits (

p
<
0.05

). Conclusions. These findings indicate that HBO therapy can decrease axon degeneration by triggering GSH activity, increasing IL-1β level, and restoring tissues and motor status. In conclusion, HBO has a protective effect on axon degeneration of the spinal cord and sciatic nerve of the AMAN model rabbit.
Numerical Simulation Study of the Strata Movement Rule of Deep Mining with the Super-Thick and Weak Cementation Overburden: A Case Study in China
Authors: Zhang Guojian , Guo Guangli , Shen Shikai , Guo Qingkun , Zhang Sifeng , Wu Jianfeng
Published: November 2021

As the national energy strategy is to mine westward, the deep coal resources under the super-thick and weak cementation overburden in the western mining area will play a critical role in China’s sustainable economic growth. The super-thick and weak cementation overburden has weaker lithology, thicker strata, no large joints, bedding development, and better integrity. Therefore, its movement rule is inevitably different from that of the weak overburden and the middle hard overburden in Central China and Eastern China. However, lack of studies on the movement of the super-thick and weak cementation overburden has led to severe constraints for the large-scale exploitation of coal resources under the super-thick and weak cementation overburden in the western mining area. This study explored the surface movement rule and the influence of overburden characteristics on strata movement with field measurement and numerical simulation. The findings indicate that the surface reaches full mining and the subsidence coefficient is about 0.9 when D1 (width in the dip direction) and D3 (length in the strike direction) are 3 times H0 (the mean mining depth) or more. The strike mining degree has a certain influence on the surface movement law, the maximum difference of the surface subsidence coefficient is 0.35, and the maximum difference of the horizontal movement coefficient is 0.05. In addition, the control effect of the Zhidan group sandstone is stronger. Thus, its first breaking results in surface sinking in a fractured manner when D1 is about 1.3 times H0 and D3 is 3 times H0 or more. The above results can provide reference for the safe mining and control of the super-thick weak cementation overburden.
piRNA-31115 Promotes Cell Proliferation and Invasion via PI3K/AKT Pathway in Clear Cell Renal Carcinoma
Authors: Du Xinghua , Li Haomin , Xie Xuexia , Shi Liping , Wu Fan , Li Guoliang , Lai Caiyong , Heng Baoli
Published: November 2021

PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that play important roles in germline development and carcinogenesis. In this study, we used the deep sequencing of small RNA Transcriptome to explore the piRNA expression in six clear cell renal carcinoma (ccRCC) tissues and matched adjacent normal tissues and found that six piRNAs were upregulated and sixteen were downregulated in ccRCC tissues. Among them, piRNA-31115 (NCBI accession number: DQ571003) was the most upregulated piRNA in ccRCC tissues compared with matched adjacent normal tissues. Quantitative real-time PCR (qRT-PCR) was used to confirm piR-31115 expression in other ccRCC tissues (

n
=
40

) and ccRCC cell lines. Besides, function analysis demonstrated that silencing of piR-31115 inhibited ccRCC cell proliferation, motility, and invasiveness. Mechanistic investigations showed that piRNA-31115 may activate epithelial-mesenchymal transition (EMT) via the PI3K/AKT signaling pathway. Hence, piR-31115 may represent an oncogene in the development of ccRCC.
Artistic Digital Display and Analysis of Interactive Media Wireless Sensor Clusters
Authors: Gao Yulong
Published: November 2021

For video art, the coupling of digital technology and postmodernist thinking has brought not only technical progress and formal transformation but also a new mode of thinking and way of living around visual experience and even a change in the whole world view. The digitalization of the image not only lies in the change of the surface form, but also it has evolved into a supermedium, connecting the real world and the virtual world, becoming a new way and means for us to grasp the world, which can be considered a huge transformation. However, while digitalization has brought great development to video art, it has also confused many issues that need to be further explored, especially the inevitable transformation in creation. This paper takes digital video art as the main object of study and explores the crisis of representation and the problem of transformation that has arisen in it, with reference to “technology,” “form,” “concept,” and even “social and cultural life.” We also analyze, summarize, and conclude the transformation of video art and its creation rules in the digital context and propose corresponding creation strategies, taking “technology,” “form,” “concept,” and even “social and cultural life“ as the starting point. For the detection of a small area, a star structure can be used to achieve a flexible arrangement of each sensor while satisfying the real‐time performance. For the collection of information in a large monitoring area, if a star structure is used, the nodes are overloaded with low reliability and low utilization of communication lines. The wireless data acquisition system uses the relatively scalable UCB telosb hardware platform, while the hardware platform uses an operating system with good portability, which can give full play to the hardware performance of the platform and effectively reduce the power consumption of the system. Based on the current art trend, this paper discusses the transformation of video art in the digital background from the perspective of “technology” and “concept” and proposes corresponding creation strategies to provide theoretical to practical support for digital video art creation practice and bring some inspiration to creators. It will also bring some inspiration to the creators. Cluster analysis is used to effectively improve the introduced algorithm, and the simulation results show that the improved algorithm can reasonably plan each sensor node in the region while reducing the number of sensors, so that the effectiveness of each sensor node can be well utilized.
Recognition of Psychological Characteristics of Students’ Behavior Based on Improved Machine Learning
Authors: Li Mingchao
Published: November 2021

Contemporary classroom teaching requires the combination of students’ classroom behavior and their psychological activities and appropriately changes the teaching mode according to students’ psychological characteristics. This paper analyzes the traditional characteristic recognition algorithm, and after improving its deficiencies, an improved characteristic extraction algorithm is proposed, based on the actual situation of classroom learning. This new algorithm can effectively improve the students’ psychological feature prediction; with the support of this algorithm, a comprehensive analysis model with classroom behavior recognition and psychological feature recognition is constructed; also, the functional structure of the system is built up. Through experimental research, the model proposed in this paper is analyzed, and the experimental data has approved that the systemic model could play an important role in classroom teaching.
Utilization of Rooftop Solar Units to Generate Electricity and Hydrogen: A Technoeconomic Analysis
Authors: Rezaei Mostafa , Jahangiri Mehdi , Razmjoo Armin
Published: November 2021

This study is aimed at scrutinizing the domestic solar energy potential for electricity and hydrogen production. Under the first scenario, it is sought to evaluate electricity generation for household purposes using RSUs (rooftop solar units). Then, under the second scenario, solar hydrogen production is analyzed for the purpose of meeting a hydrogen vehicle demand. For this, one of the aptest cities, Yazd, located in the center of Iran is investigated. Furthermore, a real-world electric load needed by an usual household in Yazd is deemed as the demand for electricity. To analyze the two scenarios, a system consisting of an 8.2 kW RSU for power generation, a battery for electricity storage, and a 1 kW electrolyzer for hydrogen yield is proposed. Also, to acquire a broader vision, predictions are made for the next 10, 20, 30, and 40 years. The results regarding the first scenario implied that COE (Cost of Electricity) would be, respectively, 0.067, 0.145, 0.136, and 0.127 $/kWh. In addition to supplying the electricity required by the house, 2,687 $/yr could be earned by selling the excess electricity generated, and 5,759 kg of CO2 would be avoided a year. The findings as to the second scenario showed that LCOH (levelized cost of hydrogen) would equate to 3.62, 6.53, 6.34, and 5.93 $/kg, respectively, for the aforementioned project lifetimes. Furthermore, 2,464 $/yr would be the revenue after selling the surplus electricity, and 7,820 kg of CO2 would be saved, annually.
Dynamic Game‐Based Computation Offloading and Resource Allocation in LEO‐Multiaccess Edge Computing
Authors: Wang Haoyu , Wang Hengli , An Jianwei
Published: November 2021

The offloading of computing tasks in edge computing has always been a research hotspot and difficulty in recent years. As an effective way to run various applications on mobile devices with limited resources, it has been extensively studied by scholars from all walks of life. However, the traditional ground‐based network‐based edge computing network architecture cannot meet the needs of edge users with limited geographic areas. Therefore, this paper proposes an LEO (low earth orbit) satellite‐based multiaccess edge computing network architecture and establishes a differential game model for this architecture. To obtain the Nash equilibrium solution of the open loop and the Nash equilibrium solution of the feedback for the task offloading amount, the relationship between the user’s income and the QoE level under the optimal task offloading amount is finally analyzed and discussed.
Antiseismic Method of Prestressed Fabricated Building Structure under Intelligent Big Data
Authors: Li Zhonghong , Huang Yong
Published: November 2021

Compared with traditional buildings, prefabricated buildings have the advantages of simple construction technology, low construction requirements, and shorter construction time, which can generate more economic benefits for the construction industry. In order to study the seismic capacity of prestressed fabricated building structures under intelligent big data, this article takes fabricated frame structures as the research object and the reinforced walls at the nodes as the starting point to study the damage patterns and energy dissipation capabilities of different seismic waves on the structure. In order to observe the overall seismic performance, the fabricated frame structure was used. The results of the study found that the prestressed fabricated building structure has the best seismic effect when the axial compression is 0.3, and the prestressed degree is below 0.5, which meets the seismic requirements. Therefore, the prestressed degree of the prestressed fabricated building structure should be below 0.5. According to statistics on the results of structural residual deformation and steel bar deformation of buildings under different seismic waves, it can be found that the prestressed fabricated building structure has better self-recovery ability and can better respond to earthquakes with different seismic waves.
Ocular Characteristics of Patients with Leber Congenital Amaurosis 6 Caused by Pathogenic RPGRIP1 Gene Variation in a Chinese Cohort
Authors: Mao Yumei , Long Yanling , Liu Bo , Cao Qingling , Li Yijian , Li Sha , Wang Gang , Meng Xiaohong , Li Shiying
Published: November 2021

Purpose. To delineate the clinical and genetic characteristics of Chinese patients with RPGRIP1-associated Leber congenital amaurosis 6 (LCA6). Methods. After screening 352 unrelated families with clinically diagnosed RP, five LCA6 patients with RPGRIP1 variations from unrelated Chinese families were identified. Full ophthalmology examinations, including decimal best-corrected visual acuity (BCVA), fundus photography, fundus autofluorescence imaging, spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ffERG), multifocal electroretinography (mfERG), perimetry, and flash visual evoked potential (FVEP), were performed. Target next-generation sequencing (NGS) and Sanger sequencing were performed for the five patients to identify and to validate candidate disease-causing variants. Results. Five patients were molecularly diagnosed as the LCA6 associated with RPGRIP1 variation, with typical clinical characteristics including congenital night blindness, nystagmus, and visual defect, at an early age. Interestingly, LCA6 exhibited extensive clinical heterogeneity and the changes in the morphology and function were not completely consistent in the five LCA6 patients. Case 1 showed extensive inferior-nasal retinal atrophy with a corresponding area of hypofluorescence in fundus autofluorescence, and the fundus photograph was nearly normal in cases 2 and 3. The ERG results displayed a moderately reduced rod-system response in cases 1 and 2 and a significant reduced rod-system response in case 3. Both case 4 and case 5 showed mottled pigmentation in fundi and an unrecordable rod and cone-system response in ERG. Moreover, we identified eight compound variants and one homozygous variant in the five patients with RPGRIP1. Conclusions. This is the largest report focused on the clinical electrophysiological features of patients with associated LCA6 caused by the variation in the RPGRIP1 gene in the Chinese population with an enriched phenotypic and genotypic background of LCA6 to improve future gene therapies.
The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA
Authors: Lee Jessica K. , Hazar-Rethinam Mehlika , Decker Brennan , Gjoerup Ole , Madison Russell W. , Lieber Daniel S. , Chung Jon H. , Schrock Alexa B. , Creeden James , Venstrom Jeffrey , Alexander Brian , Oxnard Geoffrey R.
Published: November 2021

Purpose:

Oncogenic kinase fusions are targetable with approved and investigational therapies and can also mediate acquired resistance (AR) to targeted therapy. We aimed to understand the clinical validity of liquid biopsy comprehensive genomic profiling (CGP) to detect kinase fusions pan tumor.

Experimental Design:

CGP was performed on plasma and tissue samples during clinical care. All exons plus selected introns of 16 kinases involved in oncogenic fusions (ALK, BRAF, EGFR, ERBB2, FGFR1/2/3, MET, NTRK1/2/3, PDGFRA/B, RAF1, RET, and ROS1) were sequenced to capture fusions, including well-characterized and novel breakpoints. Plasma circulating tumor DNA (ctDNA) fraction was estimated to inform sensitivity.

Results:

Of 36,916 plasma cases, 32,492 (88%) had detectable ctDNA. Kinase fusions were detected in 1.8% of ctDNA-positive cases (571/32,492) and were most prevalent in patients with cholangiocarcinoma (4.2%), bladder cancer (3.6%), and non–small cell lung cancer (NSCLC; 3.1%). Of the 63 paired patient samples that had tissue and ctDNA specimens collected within 1 year and with estimated plasma ctDNA fraction >1%, fusions were detected in 47 of 51 (92%) liquid specimens with a fusion in the tissue sample. In 32 patients with fusions detected in liquid but not in tissue, 21 (66%) had evidence of putative acquired resistance.

Conclusions:

Targetable kinase fusions are identified in ctDNA across cancer types. In pairs with tissue-identified fusions, fusion detection in ctDNA is reliable with elevated ctDNA fraction. These data support the validity of CGP to enable ctDNA-based fusion detection for informing clinical care in patients with advanced cancer.
Pyrotinib in Patients with HER2-Amplified Advanced Non–Small Cell Lung Cancer: A Prospective, Multicenter, Single-Arm Trial
Authors: Song Zhengbo , Lv Dongqing , Chen Shi-Qing , Huang Jianjin , Li Yuping , Ying Shenpeng , Wu Xiaoyu , Hua Feng , Wang Wenxian , Xu Chunwei , Bei Ting , Gao Chan , Sun Zhijian , Zhang Yiping , Lu Shun
Published: November 2021

Purpose:

In this study, we aimed to evaluate the efficacy and safety of pyrotinib, a pan-HER inhibitor, in patients with HER2-amplified non–small cell lung cancer (NSCLC).

Patients and Methods:

In this prospective, multicenter, single-arm trial (ChiCTR1800020262), patients with advanced NSCLC with HER2 amplification, as determined by next-generation sequencing, were enrolled and administered pyrotinib orally at 400 mg per day. The primary endpoint was 6-month progression-free survival (PFS) rate. Other endpoints included objective response rate (ORR), disease control rate (DCR), PFS, overall survival (OS), and safety.

Results:

The enrolled cohort included 27 patients with HER2 amplification. The 6-month PFS rate was 51.9% [95% confidence interval (CI), 34.0–69.3]. The median PFS (mPFS) was 6.3 months (95% CI, 3.0–9.6 months), and median OS was 12.5 months (95% CI, 8.2–16.8 months). Pyrotinib elicited a confirmed ORR of 22.2% (95% CI, 10.6%−40.8%). Patients administered pyrotinib as first-line treatment achieved an mPFS of 12.4 months. Moreover, 30.8% of the patients who had progressed on EGFR tyrosine kinase inhibitor (TKI) responded to pyrotinib. Patients with brain metastases had an ORR of 40%. Treatment-related adverse events (TRAE) occurred in all patients (grade 3, 22.2%), but no grade 4 or higher TRAEs were documented. Diarrhea was the most frequent TRAE (all, 92.6%; grade 3, 7.4%). Loss of HER2 amplification was detected upon disease progression.

Conclusions:

Pyrotinib provided antitumor efficacy with a manageable safety profile in HER2-amplified patients with NSCLC.
Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia
Authors: Mehta Vikita , Kirubarajan Abirami , Sabouhanian Amir , Jayawardena Sanasi M. , Chandrakumaran Priya , Thangavelu Nila , Cader Refai , Mettananda Sachith , Bandara Dayananda , Khan Shawn , Weatherall David J. , Allen Angela , Premawardhena Anuja P. , Olivieri Nancy F.
Published: November 2021

Background: Leg ulcers are a frequent complication in patients with the inherited hemoglobin disorders. In thalassemia, the literature is limited, and factors associated with the development of leg ulcers in hemoglobin E (HbE) beta thalassemia, the most common form of severe beta-thalassemia worldwide, have not previously been reported. Methods: We reviewed all available medical records of patients with HbE beta thalassemia to document the onset of leg ulcers at the 2 largest treatment centers in Sri Lanka. We reviewed the literature to identify studies reporting outcomes of interventions for ulcers in severe thalassemia. Results: Of a total of 255 actively registered patients with HbE thalassemia in the 2 centers, 196 patient charts were evaluable. A leg ulcer with a documented date of onset was recorded in 45 (22%) of 196 evaluable patients, aged (mean ± SEM) 22.2 ± 1.4 years. Most had been irregularly transfused; steady-state hemoglobin was 6.4 ± 0.2 g/dL. Treatment achieving healing in 17 patients included transfusions, antibiotics, oral zinc, wound toileting, and skin grafting. Conclusion: Leg ulcers may be more common in HbE beta thalassemia than in other forms of thalassemia. A systematic approach to treatment will be needed to document the prevalence and factors placing such patients at risk for leg ulcers. Controlled trials to evaluate the optimal treatment of this common complication are indicated.
Rastejar como ato terrorista: um corpo desobediente rasgando calçadas do gênero
Authors: Marinelli Princesa Ricardo
Published: November 2021

Espaço para publicações de propostas diversas que se apresentam em outros formatos que não no modelo de artigos. Os materiais publicados nesta seção podem ser organizados como textos, entrevistas, dramaturgias, imagens visuais, imagens sonoras, partituras, entre outras possibilidades.
Comportamento sedentário e competência motora em crianças e adolescentes: revisão
Authors: Santos Guilherme dos , Guerra Paulo Henrique , Milani Suedem Andrade , Santos Ariane Brito Diniz , Cattuzzo Maria Teresa , Ré Alessandro Hervaldo Nicolai
Published: November 2021

OBJETIVO Sintetizar as evidências de estudos que analisaram as associações entre comportamento sedentário e competência motora em crianças e adolescentes. MÉTODOS Revisão sistemática de artigos originais que analisaram possíveis associações entre comportamento sedentário e competência motora em crianças e adolescentes (3–18 anos de idade), sem restrições quanto ao delineamento de estudo, instrumentos e protocolos de análise. Os artigos foram identificados por meio de buscas nas bases PubMed, Web of Science, Academic Search Premier, Cinahl, Medline e SPORTDiscus, assim como em listas de referências. O nível de evidência foi avaliado de acordo com a quantidade de estudos que reportaram significância estatística nas associações entre as variáveis e a qualidade dos artigos (o risco de viés). RESULTADOS De 2.462 estudos iniciais, 22 compuseram a síntese (duas intervenções, nove longitudinais e onze transversais). Desses, em 13 foram observadas associações negativas entre as variáveis, mais frequentemente na faixa etária de sete a catorze anos. Na análise do risco de viés, as principais limitações dos estudos foram “amostragens por conveniência” e “não descrição do dimensionamento amostral”. CONCLUSÕES A evidência disponível sugere que o comportamento sedentário está negativamente associado à competência motora em crianças do ensino fundamental, embora a evidência seja incerta nos anos pré-escolares; a síntese de resultados dos estudos longitudinais sugere que o comportamento sedentário afeta negativamente o desenvolvimento da competência motora. É importante que futuros estudos tenham maior controle sobre os determinantes socioculturais e aprofundem os conhecimentos em relação ao sexo e à faixa etária, assim como dos métodos e indicadores utilizados para avaliação das duas variáveis.
Avaliação de Tecnologias em Saúde: informada pela ciência ou a serviço da política?
Authors: Soárez Patrícia Coelho De
Published: November 2021

A juventude da Avaliação de Tecnologias em Saúde (ATS), enquanto política institucional no âmbito nacional, sinaliza a necessidade de uma reflexão sobre como se deu sua implementação, sob as perspectivas de sua inserção na política de saúde e do campo científico. Ao final de sua primeira década, levantam-se as perguntas: a ATS se traduziu em uma política de saúde (policy) informada pela ciência? Sua fundamentação científica foi usada a serviço da política (politics)? Para compreender esse processo político, aplicamos a teoria de múltiplos fluxos formulada por John Kingdon. Estabeleceu-se um equilíbrio instável entre o uso da ciência para informar a política e o uso político da ciência. A sobrevivência dessa política dependerá não só da ciência, mas da arte de orquestrar os interesses dos vários agentes, de forma que a ATS se torne uma política de saúde de fortalecimento e sustentabilidade do SUS.