bluuebunny/crossref_metadata_2025 huggingface dataset:
Generating Confidence in the Healthcare System through Information Activities of Healthcare Institutions
Authors: Vasylyev Yuriy , Savchenko Iryna , Us Yana , Veckalne Regina
Published: July 2022

The modern snowballing development of informatization processes significantly impacts the healthcare sector, especially the doctor-patient relationship. It requires the analysis of the social, psychological, and moral aspects of the doctor-patient relationship in the information society to search for more effective models of medical communication, increase the trust in the healthcare system, and develop the mechanisms for resolving growing conflicts and contradictions in the doctor-patient relationship. Thus, this study aims to assess the healthcare of Ukraine to elaborate the recommendations for the administration of the healthcare institutions on conducting the relevant information activities to increase the trust level in the healthcare system. This study involved comparative, analytical, statistical, and questionnaire research methods to achieve the above goal. The research information base is the legal framework, relevant scientific treatises, scientific and practical conference materials, statistical reference books, and Internet resources. The quantitative research relies on a questionnaire survey of 203 inhabitants of the Sumy region conducted on social networks and public hospitals. The survey findings showed that most population does not trust the healthcare system of Ukraine and assesses the state of medicine as satisfactory. At the same time, the information policy in Ukraine requires improvements, while employees of healthcare institutions should be more engaged in innovative development. The survey results confirmed the low communication between doctors and patients. Therefore, this study recommends strengthening the relationships between doctors and patients and increasing the information literacy of medical professionals. The obtained results have practical value. They could be helpful to the healthcare institutions’ administration in conducting information activities concerning improving the patients’ attitude toward the healthcare system and state healthcare institutions; raising the information literacy among citizens and medical workers; ensuring a responsible attitude of the people toward their health; paying sufficient attention to disease prevention under the family doctor’s recommendations.
Exit-Site Infection Caused by Lysinibacillus Sphaericus: Unusual Organism From A Usual Site
Authors: Jangla Sunayana Mukesh
Published: July 2022

Exit-site infection is an unwanted complication in patients with an indwelling catheter. However, such an infection by an uncommon organism like Lysinibacillus which is otherwise considered an environmental contaminant needs to be mentioned. Our report describes one such case. The patient was given antibiotic as per antibiotic susceptibility report to which he responded.
Mordecai Roshwald’s Level 7: A Record of the Inverted Pyramid Society with No Exit
Authors:   British And American Language And Literature Association Of Korea, Kim Younghee
Published: July 2022

This study explores how an inverted pyramid society collapses in the aftermath of formidable nuclear attacks in Mordecai Roshwald’s Level 7 . In this novel, composed in the form of a diary of a ‘push button’ officer called X-127, Roshwald emphasizes that a society established on a distorted value system in the shape of an inverted pyramid is doomed to failure from the beginning. Humanity’s arrogance and blind faith in science and technology reduces human beings to machine-like half beings. The members of this enclosed and suffocating underground shelter cannot get out of the machine state and end up in irreversible catastrophe. The narrator X-127, however, is transformed from a callous human machine to Homo Empathicus through his reflective record of the world after the Bomb. This research identifies the typical characteristics of the constricted society in Level 7 and examines some similarities and differences between this novel and some other dystopian or post-apocalyptic narratives. It also traces the way X-127’s record of a sequence of events leads to his epistemological transformation as a subjective and independent individual.
RECURRENT ANTERIOR SHOULDER DISLOCATION TREATED BY OPENINFERIOR GLENOHUMERAL LIGAMENT RECONSTRUCTION
Authors: El Kawafi Majde , Ettajouri Idris , Bohalfaya Mabrouk
Published: July 2022

The anterior capsulolabralcomplex repair with inferior glenohumeral ligament reconstruction has been encouraging predominantly in young active population, and heavy workers with traumatic anterior shoulder dislocation. The aim of this study was to assess the clinical outcome of patients who underwent inferior glenohumeral ligament reconstruction for recurrent traumatic anterior shoulder instability by the open method. A prospective study of 40 patients with a mean age of 30 years ( 20 â€“ 50 years ) who underwent open reconstruction of the inferior glenohumeral ligament ( RIGHL) to treattraumatic recurrent anterior shoulder dislocation was conducted. All patients met the criteria for inclusion in the study. They had traumatic anterior shoulder dislocation with subsequent recurrent instability. All were males with no professional athletes among them. Detachment of the dominant shoulder from the glenoid marginwas found in all cases . No patient had surgical intervention before. Twenty patients had the right shoulder affected. All patients were evaluated by physical examination and followed for a minimum of 6 months (15-80 months). Rowe score was used for the clinical assessment of patients. The mean modified Rowe score was 93.3% (65% -100%) with 92.3% good and excellent results. There were 14 excellent, 10 good, 5 fair, and 3 poor results due to redislocation after major trauma ( RTA). There was no loss of range of motion compared to preoperative values. These observations point out that glenoid sided capsulolabral repair can reestablish shoulder stability in patients with recurrent traumatic anterior dislocation, and success rates comparable to those of other open anterior shoulder repair procedures can be achieved. Although arthroscopic repair for recurrent shoulder instability is a choice for most surgeons nowadays, open repair remains an excellent option and should not be forgotten especially with the lack of experience or arthroscopic availability.
On streamlining the Ukrainian names of plant. Information 13. Taxonomic diversity and names for subtropic fruit plants of the Khorol Botanical Garden collection
Authors: Mezhenskyj V. M. , Mezhenska L. O. , Krasovskyi V. V. , Cherniak T. V. , Fedko R. M.
Published: July 2022

Purpose. To analyse the taxonomic composition of subtropical plants of the Khorol Botanical Garden collection.
Results. Taxonomic composition of the collection, consisting of 25 species: Actinidia chinensis Planch., Asimina triloba (L.) Dunal, Camellia sinensis (L.) Kuntze, Chaenomeles ×californica Clarke ex Weber, Citrus trifoliata L., Cormus domestica L., Crataegus azarolus L., Crataegus opaca Hooker & Arn., Cydonia oblonga Mill., Diospyros virginiana L., Elaeagnus multiflora Thunb., Elaeagnus umbellata Thunb., Feijoa sellowiana O.Berg, Ficus carica L., Hovenia dulcis Thunb., Laurus nobilis L., Maclura tricuspidata (Carrière). Bureau, Olea europaea L., Passiflora incarnata L., Prunus armeniaca L., Prunus dulcis (Mill.) D.A.Webb, Punica granatum L., and Ziziphus jujuba Mill., which according to the current classification belong to 22 genera, 15 families, 8 orders of flowering plants was found out. Each species represents a certain fruit crop: apricot, azarole, pawpaw, quince, akigoumi, American persimmon, pomegranate, goumi, service tree, Chinese date, kiwi, che, laurel, olive, mayhaw, almond, medlar, Oriental raisin tree, fig, passion fruit, trifoliate orange, pineapple guava, pistachio, tea, and Japanese quince.
Conclusions. The taxonomic composition of the collection of subtropical plants in the Khorol Botanical Garden was specified and the Ukrainian names of 17 taxa of the species level, 12 of the generic, 4 of the family and 5 of the ordinal levels were streamlined. The Ukrainian names of botanical taxa need to be brought into line with the modern phylogenetic system, correcting inconsistencies inherited from Soviet times. The naming of genera of subtropical cultures in the Ukrainian language occurs most often through the transliteration of the corresponding Latin names or the formation of new names with direct word order in two-word names using long-learned names of related genera. The names of subtropical crops in the agrobiological terminological system may coincide with the names of botanical genera or are borrowed trivial names of plants in different languages from the regions from which they were introduced. Two-word names of crops and species names differ in word order, respectively, direct and reverse.
Biochemical composition and allelopathic properties of sweet sorghum seeds [Sorghum bicolor (L.) Moench]
Authors: Storozhyk L. I. , Voitovska V. I. , Tereshchenko I. S. , Zavhorodnia S. V.
Published: July 2022

Aim. To establish the main composition of allelochemicals and the activity of their aqueous extracts from sweet sorghum seeds – hybrids with high and medium sugar content ‘Sugargraze ARG’ (Argentina), ‘Sioux’ (USA) and ‘Ananas’ (Ukraine) on germination energy and seed germination of test crops (peas, clover).
Methods. Allelopathic, physiological-biochemical, agrochemical and statistical methods were used. The allelopathic activity of extracts (water-soluble) from the seeds of the studied sorghum hybrids was determined by direct biotesting. The chemical component of allelopathically active substances was determined by extraction.
Results. Aqueous extracts from sweet sorghum seeds of hybrids ‘Sugar­graze ARG’, ‘Sioux’ and ‘Ananas’ were found to have a high content of phytochemicals and at a concentration of 40 and 50% inhibited the germination energy and germination of pea and clover seeds by an average of 15–42%. Aqueous extracts of concentrations from 5 to 30% of the studied hybrids showed a stimulating and tolerant effect on the quality of seeds of biotest crops of clover and peas, as germination rates were at the level of control or 5–7% higher, i.e. showed the least allelopathic activity.
Conclusions. Sweet sorghum seeds have a sufficient number of allelochemicals, the specificity of which depends on varietal differences in the content of phenolic compounds (glycosides), tannins, acids and carbohydrates. The activity of the allelochemicals extracted from the seeds was weak in the stimulating effect and high in the inhibitory one. For water-soluble extracts from sorghum seeds, a sharp decrease in the manifestation of allelopathic activity is characteristic when their concentration decreases to 5–20%. Studies of water-soluble extracts of seeds at a concentration of 30–50% showed their high overall allelopathic activity, which was manifested in the inhibition of seed germination of biotest crops by 42%. The species-specific action of allelochemicals must be taken into account when sowing multicomponent fields, crop rotation planning, and the use of sweet sorghum as green manure.
How chatbot e-services motivate communication credibility and lead to customer satisfaction: The perspective of Thai consumers in the apparel retailing context
Authors: Jansom Akawut , Srisangkhajorn Thaksaorn , Limarunothai Wutticha
Published: July 2022

A Correction to this article was published on 13 July 2023
Many apparel retailing brands use e-service marketing tools such as a chatbot (a system that is available 24 hours a day, 7 days a week) to increase their competitive advantage in today’s world of digitalization. During the COVID-19 pandemic, chatbots gained more power to serve as a communication tool that provides information and maintains customer experience. Therefore, this study is conducted to investigate the influence of chatbot e-service agents’ marketing efforts (involving interaction, entertainment, trendiness, and problem-solving) on Thai customers’ perceived communication credibility and satisfaction in apparel retailing, as research in this area is limited. In order to test the hypotheses, the paper employed structural equation modeling using Amos. In addition, an online survey of 400 Thai consumers who had previously used chatbots in the apparel retailing industry was conducted. The results showed that chatbot e-service marketing efforts, including interaction, trendiness, and problem-solving, affected customer satisfaction without entertainment elements. Beyond this, a chatbot, viewing interaction and entertainment, was found to have an insignificant effect on communication credibility. Thus, the coefficient value proved that information regarding communication credibility is more dominant in customer satisfaction. Therefore, the chatbot e-service marketing effort is essential in motivating communication credibility in customer satisfaction. These findings delivered managerial implications for understanding consumers in the field of digitalization.
Validity of reasons for the plaintiff’s default at trial as a qualifying feature of leaving the statement of claim without consideration: de lege lata i de lege ferenda
Authors: Vorobel U.
Published: July 2022

The features of leaving the statement of claim without consideration in connection with the repeated plaintiff’s default as the nature of the reasons for his/her absence at trial are investigated. In particular, the degree of influence of their validity on the exercise of court powers to terminate proceedings without a court decision on the merits of civil claims is studied. Attention is paid to the necessity and expediency of taking into account the valid reasons for non-appearance of the plaintiff and (or) his/her representative in determining the legal consequences of his/her default at trial. In particular, applying to the institution of leaving the statement of claim without consideration, on the grounds provided for in paragraph 3 of Part 1 of Art. 257 of the Civil Procedure of Ukraine, which will ensure the balance of interests of the plaintiff and the defendant in the proceedings: the plaintiff will be guaranteed the possibility of practical exercise of his/her right to a fair trial, and the defendant will be protected from excessive delay of the case.The provision that the validity of reasons for the plaintiff's default at trial should remain an evaluative category is substantiated. It is decided by the court in each case separately, taking into account a combination of such factors as 1) the nature of the circumstances preventing the plaintiff's appearance at trial; 2) the proof of their existence by appropriate and admissible evidence; 3) the degree of influence of these circumstances on the impossibility of the plaintiff's appearance at trial; 4) the impossibility of using other alternates (regimes) of participation at trial; 5) the preliminary behavior of the plaintiff and (or) his/her representative in the case, the complexity of the case, the quantitative characteristics of the court hearings in the case, the total duration of the civil proceedings, etc. If the court, taking into account the above-mentioned criteria, finds such a circumstance to be unreasonable for the plaintiff's default at trial, the court should argue the reasons for such a decision on each of these criteria, which would ensure the objectivity and validity of the court interpretation of such a legal construction as "the validity of the reasons for default at trial".
Administrative and legal regulation of the provision of financial services in Ukraine: a comparative aspect
Authors: Shapoval R. , Orlovskiy R. , Solntseva K.
Published: July 2022

The formation of an appropriate mechanism of administrative and legal regulation of services in the field of financing was carried out at each stage of its development by annually expanding the theoretical (legislative and doctrinal-scientific) and practical basis, providing greater opportunities for consumers to exercise their rights to prompt and prompt service. To date, the topic studied by the authors is one of the most developed in Ukraine. The article analyzes the possibility of formulating a quality mechanism of administrative and legal regulation of financial services in Ukraine through the prism of European integration processes and preventive measures. An extensive analysis of the current financial system of Ukraine is given. The administrative-legal, informational and anti-corruption components of the regulation of financial services are highlighted. It was also found that an important new form of incentive funding for the regions were competitions for budget subventions for the achievement of achievements, rather than their absolute level, which allows them to participate effectively in depressed regions. The strategy of development of the Ukrainian financial market is aimed at its transformation into the main mechanism for attracting investment by Ukrainian companies, creating conditions for effective investment of private and pension savings. The authors revealed the steps and stages of establishing the procedure for providing financial services in terms of such an integral principle of the modern formation of the process of providing services in Ukraine as the principle of service. As a result of the study, in addition to the classic administrative component of financial services, information and anti-corruption services were singled out. The general and special jurisdiction for committing offenses in the field of regulation of financial services at the level of bylaws of Ukraine is analyzed.
Administration by Giving Verbal Orders from the Perspective of Military Legal Relations
Authors:   Military University of the Ministry of Defense of Russia, Glukhov E.A.
Published: July 2022

The article analyzes norms of domestic and foreign military legislation concerning the procedure of execution of the order by military personnel. The article explores cases when the implementing of those orders can be harmful to the interests that are protected by law. The author distinguishes the differences of the order for the military personnel and civil officer; it is pointed out for whom the order is obligatory and who has the right to appeal and who will be liable for failure to execute the order. On one hand, the author emphasizes the inability for the military personnel to evade the execution of the order under the threat of legal sanctions; on the other hand, the article shows the possibility to execute an order as the form of complicity in a crime. The author cites typical examples of military officers’ orders that could lead to committing of crimes or to criminal prosecution of the executor. The author examines the orders that contradicts the norms of morality. The article explores the experience of evaluating military orders from the point of view of the military personnel in some foreign countries (for instance, in the USA, Germany, Italy, Slovakia, Singapore). The author analyzes reasons and conditions of non-critical and even thoughtless attitude of the military personnel to any given orders. On the grounds of the found contradictions, the suggestions are expressed to try and make the Russian legislation more perfect by providing the military personnel with the ability to assess all given orders and see if they correlate with the law and the norms of morality. In the peacetime, the military personnel should have to right to inquire written orders if they are doubtful in the legal grounds of any give verbal order.
Radiopharmaceuticals Regulations: Current Scenario and the Way Forward
Authors: Sharma Navneet , Kaur Harvinder , Sharma Rakesh Kumar
Published: July 2022

Background: Over the past decade, there has been great development arising in the
field of Molecular imaging and Nuclear medicine using innovative Radiopharmaceuticals. The
Radiotherapy practices are also expanding due to increasing number of Cancer cases and technological
advances. Indian market is also emerging as a foremost country to carry out research for a
new drug. There is a need for the implementation of strict guidelines to assess the quality, safety,
and efficacy of Radiopharmaceuticals.

Discussion: Radiopharmaceuticals have proven its therapeutic potential but it still comes in
Schedule K of Drugs & Cosmetic Act 1940 and the rules frames there under. There is a need to
provide it a status of the drug. This review aims to highlight the current regulatory challenges
faced by Radiopharmaceuticals regarding various issues.

Conclusion: These unique issues intensify the concern for stipulated guidelines for conducting
preclinical studies, clinical trials, bioavailability and bioequivalence studies of radiopharmaceuticals.
It helps in drafting the uniform regulatory framework with respect to the radiopharmaceuticals
which are accepted globally by the investigator.
The Development of an Egg Incubator Prototype with the Use of Heat on the Condenser Side of the Refrigerator
Authors: Budiastawan Ngurah Putu , Wiratmaja I Gede , Nugraha I Nyoman Pasek
Published: July 2022

The development for an egg incubator prototype with the use of heat on the condenser side of the refrigerator belongs to  Research and Development (R&D) conductment with the aim of knowing the process of developing an egg incubator prototype by using heat on the condenser side of the refrigerator to find out the feasibility  level. The method in this study uses Quality Function Deployment (QFD), which is a method used in the early stages of product design and development that makes quality design of a product based on the market quality demand and order of the customer. The prototype development process undergo  several stages, including: preliminary survey to the farmer community, design, instrument validity testing, prototype making, media export testing and small group testing. Based on the calculation of the results of the validity test assessment by the instrument content expert, the content validity value of 1 which refers to the instrument validity criteria table is included in the very high validity criteria. Furthermore, based on the calculation of the validation results from the media expert test and the small group test, it gets a percentage of 100% for the media expert test and a percentage of 95.20% for the small group test and refers to the eligibility level qualification table with a scale of 5 in the very appropriate category without the need for revision, so that the  developed prototype egg incubator  are suitable for use and marketable for the industry.
Branding for province: is it useful? Study on branding communications of Jateng Gayeng in the Ganjar Pranowo’s leadership
Authors: Rahmanto Andre Noevi
Published: July 2022

The Central Java Provincial Government launched the slogan and logo for the Jateng Gayeng but in practice it is not easy because of the different roles of the provincial government in the era of regional autonomy. While on the other hand, many regency/municipal already have their own branding. This research with a qualitative approach was conducted to examine the branding process of the Central Java Provincial government through the branding of Jateng Gayeng. A series of qualitative interviews with four key informants, focus group discussions attended by twelve regency/municipal government representatives, and document analysis were conducted to examine the processes involved in designing and implementing branding. The results showed that in branding Jateng Gayeng, the government of Central Java Province was more likely to use secondary communication in the form of logos and slogans. Communication with stakeholders is more likely to use an informative strategy than a collaborative one. The emergence of provincial branding in Central Java has useful and potential to strengthen district/city branding.
Commodification of Betawi culture of Palang Pintu festival
Authors: Mansur Suraya , Saragih Nurhayani , Novianti Wiwik , Istiyanto S Bekti , Mahligai Utas
Published: July 2022

The Kemang Palang Pintu Festival is an annual event. The purpose of this event is to preserve culture and celebrate the anniversary of the city of Jakarta. The organizers display many Betawi cultural arts while visitors who come are not only Betawi residents. This study uses a constructivist qualitative approach. The research method used is a case study by conducting interviews direct observation to make observations. The technique of checking the validity of the data is using the source triangulation technique. The results of this study indicate that the Kemang Palang Pintu Festival has carried out good planning. Starting from selection of participants, the technical meeting of event agenda, to the mechanism of the event rundown. Have conducted a visitor satisfaction survey but have not processed the data as a reference for the next implementation. The technique of compiling messages has been well designed in order to attract visitors and convey the meaning of the message that is the purpose of the event. This doorstop festival is a commodity process that provides selling power. The advantages in this case are various forms, both material and non-material (the existence of sanggar studios).
Hegemonic dialectics between power and resistance in the Indonesian sharing economy: Study of Gojek
Authors: Asih Irsanti Widuri , Nugroho Heru , Budiawan Budiawan
Published: July 2022

Gojek is an Indonesian platform-based on-demand ride-hailing business that has attracted some researchers to conduct studies in this newly emerged economy field through various approaches. Most researchers see the phenomenon of Gojek as part of the global disruptive technology movement that positively impacts the Indonesian economic and socio-cultural aspects of society. Some others expose the asymmetrical relationship between the platform and its driverpartners. No study analyzed it from the perspective of a dialectical hegemony that transpires between the platform and its driver-partners. Using a qualitative method, this article will fill in the gaps in the study of the Gojek phenomenon from the Gramscian Theory of Hegemony perspective to uncover the dialectical relationship between the digital platform and its driver-partners. The platform articulates hegemony actions through gamification and algorithm system, the concept of work, the internalization of corporate values, the Award Programs, the Kopi Darat Program, the driver-partners communities, Gojek’s Task Force and the driver-partners influencers. The driver-partners perform resistance by conducting demonstrations and boycotts, using various application modifications, and serving over one platform.
Growth trends for selected occupations considered at risk from automation
Authors: Handel Michael
Published: July 2022

Breakthroughs in artificial intelligence (AI) and robotics have led to substantial concern that large-scale job losses are imminent. Selected occupations are often cited as illustrations of technological displacement that is or will become a more general problem, but these discussions are often impressionistic. This article compiles a list of specific occupations cited in the automation literature and examines the occupations’ employment trends since 1999 and projected employment to 2029. There is little support in U.S. Bureau of Labor Statistics data or projections for the idea of a general acceleration of job loss or a structural break with trends pre-dating the AI revolution with respect to the occupations cited as examples. Offsetting factors and other limitations of the automation thesis are discussed.
Using a Digital Approach to Improving Mental Health in Adults With Self-reported Psoriasis: An Analysis of Real-world User Data
Authors: Boucher Eliane , Honomichl Ryan , Zucker Murray
Published: July 2022

Background

Visible scales and perceived stigma often lead to feelings of embarrassment, shame, low self-esteem, and self-consciousness among people with psoriasis. Beyond the negative effects of this distress on mental health, some researchers also argue that the inflammatory response caused by psoriasis predisposes patients with psoriasis to mental health conditions like depression. Given that anxiety and depression are linked to higher disease activity and pain in patients with psoriasis, researchers have argued that an important component of any psoriasis management plan should include addressing mental health. However, a shortage of mental health professionals, particularly in low income and rural areas, makes access to mental health care more challenging than many other common referrals—a problem that has been exacerbated in light of the COVID-19 pandemic.

Objective

This study aims to explore the feasibility of using a digital mental health intervention to help improve subjective well-being and anxiety among adults with self-reported psoriasis.

Methods

Real-world users who signed up for the digital wellness program, Happify, between January 1, 2017, and June 10, 2021, and who reported having psoriasis during onboarding were included in this analysis. To qualify, users had to complete at least two in-app assessments (which include a proprietary measure of subjective well-being, the Happify Scale, and the Generalized Anxiety Disorder 2 scale to measure anxiety), complete at least 1 Happify activity, complete no more than 3 activities before taking their first assessment, and had to have at least 42 days between their first and last assessment. We examined changes in well-being and anxiety among these participants based on Happify use (recommended vs less than recommended).

Results

Users who engaged with the program at the recommended level experienced significantly greater improvements in both well-being (P<.001) and anxiety (P=.01). More specifically, users who completed the recommended number of activities improved their well-being scores by 26.8%, whereas users who completed fewer activities improved their well-being scores by only 4.11%. Similarly, users who completed the recommended number of activities improved their anxiety scores by 26.64%, compared to 8.15% among those who engaged below the recommended level.

Conclusions

These data suggest that a digital mental health intervention can effectively improve both subjective well-being and anxiety among patients with psoriasis when used at the recommended level. Although future research is required to better understand whether this subsequently impacts disease-specific outcomes, such as disease activity and pain, our data suggest that a digital approach may be one method of providing greater access to mental health support for patients with psoriasis, increasing the likelihood that it can be incorporated into their treatment plan.

Conflicts of Interest

None declared.
Impact of COVID-19–related Isolation on Individuals in Treatment for Substance Use
Authors: Ondrusek Ashlin Ripley , Townsend Emily , Warnock Charles , Lowe Sarah , Muilenburg Jessica , Kershaw Trace
Published: July 2022

Background

For individuals in treatment for substance use, supportive social networks are essential to protect against a return to use.

Objective

This study aimed to explore the impact of the swift and severe isolation brought on by the COVID-19 pandemic, specifically for individuals in treatment for substance use disorder, by exploring the relationships amongst social connectedness and isolation to treatment accessibility, mental health, and substance use.

Methods

A total of 24 semistructured interviews were conducted from May 2020 to August 2020 with participants engaged in substance use treatment asking about the impact of the pandemic on social networks, substance use, access to treatment, and mental health. Interviews were coded and analyzed using grounded theory.

Results

Results centered around two main themes: (1) access to support (eg, formal and informal networks) and (2) individual outcomes regarding substance use and worsened mental health.

Conclusions

This research suggests that the COVID-19 pandemic has greatly disrupted access to resources for individuals in treatment for substance use, and calls for treatment centers and governing bodies to put more resources into telehealth and alternative treatment plans in the event of major disruptions, such as national disasters and global pandemics.

Conflicts of Interest

None declared.
Developing an Artificial Intelligence Model for Reading Chest X-rays: Protocol for a Prospective Validation Study
Authors: Miró Catalina Queralt , Fuster-Casanovas Aïna , Solé-Casals Jordi , Vidal-Alaball Josep
Published: July 2022

Background

Chest x-rays are the most commonly used type of x-rays today, accounting for up to 26% of all radiographic tests performed. However, chest radiography is a complex imaging modality to interpret. Several studies have reported discrepancies in chest x-ray interpretations among emergency physicians and radiologists. It is of vital importance to be able to offer a fast and reliable diagnosis for this kind of x-ray, using artificial intelligence (AI) to support the clinician. Oxipit has developed an AI algorithm for reading chest x-rays, available through a web platform called ChestEye. This platform is an automatic computer-aided diagnosis system where a reading of the inserted chest x-ray is performed, and an automatic report is returned with a capacity to detect 75 pathologies, covering 90% of diagnoses.

Objective

The overall objective of the study is to perform validation with prospective data of the ChestEye algorithm as a diagnostic aid. We wish to validate the algorithm for a single pathology and multiple pathologies by evaluating the accuracy, sensitivity, and specificity of the algorithm.

Methods

A prospective validation study will be carried out to compare the diagnosis of the reference radiologists for the users attending the primary care center in the Osona region (Spain), with the diagnosis of the ChestEye AI algorithm. Anonymized chest x-ray images will be acquired and fed into the AI algorithm interface, which will return an automatic report. A radiologist will evaluate the same chest x-ray, and both assessments will be compared to calculate the precision, sensitivity, specificity, and accuracy of the AI algorithm. Results will be represented globally and individually for each pathology using a confusion matrix and the One-vs-All methodology.

Results

Patient recruitment was conducted from February 7, 2022, and it is expected that data can be obtained in 5 to 6 months. In June 2022, more than 450 x-rays have been collected, so it is expected that 600 samples will be gathered in July 2022. We hope to obtain sufficient evidence to demonstrate that the use of AI in the reading of chest x-rays can be a good tool for diagnostic support. However, there is a decreasing number of radiology professionals and, therefore, it is necessary to develop and validate tools to support professionals who have to interpret these tests.

Conclusions

If the results of the validation of the model are satisfactory, it could be implemented as a support tool and allow an increase in the accuracy and speed of diagnosis, patient safety, and agility in the primary care system, while reducing the cost of unnecessary tests.

International Registered Report Identifier (IRRID)

PRR1-10.2196/39536
Comparison of the Impact of Insulin Degludec U100 and Insulin Glargine U300 on Glycemic Variability and Oxidative Stress in Insulin-Naive Patients With Type 2 Diabetes Mellitus: Pilot Study for a Randomized Trial (Preprint)
Authors: Vrebalov Cindro Pavle , Krnić Mladen , Modun Darko , Vuković Jonatan , Tičinović Kurir Tina , Kardum Goran , Rušić Doris , Šešelja Perišin Ana , Bukić Josipa
Published: July 2022

BACKGROUND

There is an ongoing discussion about possible differences between insulin degludec (IDeg-100) and glargine U300 (IGlar-300). There is little data and head-to-head comparison of IDeg-100 and IGlar-300 regarding their simultaneous impact on glycemic variability and oxidative stress in patients with type 2 diabetes mellitus (T2DM).

OBJECTIVE

In our randomized, open-label, crossover study, we compared the impact of IDeg-100 and IGlar-300 on glycemic variability and oxidative stress in insulin-naive patients with T2DM.

METHODS

We recruited a total of 25 adult patients with T2DM (7 females) whose diabetes was uncontrolled (HbA1c ≥7.5%) on two or more oral glucose-lowering drugs; a total of 22 completed the study. Mean age was 57.3 (SD 6.99) years and duration of diabetes was 9.94 (SD 5.01) years. After the washout period, they were randomized alternately to first receive either IDeg-100 or IGlar-300 along with metformin. Each insulin was administered for 12 weeks and then switched. At the beginning and end of each phase, biochemical and oxidative stress parameters were analyzed. On 3 consecutive days prior to each control point, patients performed a 7-point self-monitoring of blood glucose profile. Oxidative stress was assessed by measuring thiol groups and hydroperoxides (determination of reactive oxygen metabolites test) in serum.

RESULTS

IGlar-300 reduced mean glucose by 0.02-0.13 mmol/L, and IDeg-100 reduced glucose by 0.10-0.16 mmol/L, with no significant difference. The reduction of the coefficient of glucose variation also did not show a statistically significant difference. IGlar-300 increased thiols by 0.08 µmol/L and IDeg-100 increased thiols by 0.15 µmol/L, with no significant difference (P=.07) between them. IGlar-300 reduced hydroperoxides by 0.040 CARR U and IDeg-100 increased hydroperoxides by 0.034 CARR U, but the difference was not significant (P=.12).

CONCLUSIONS

The results of our study do not show a significant difference regarding glycemic variability between patients receiving either insulin IDeg-100 or IGlar-300, although IGlar-300 showed greater dispersion of data. No significant difference in oxidative stress was observed. In a larger study, doses of insulins should be higher to achieve significant impact on glycemic parameters and consequently on glycemic variability and oxidative stress.

CLINICALTRIAL

ClinicalTrials.gov, NCT04692415; https://clinicaltrials.gov/ct2/show/NCT04692415
Telepsychiatry in the Postpandemic Future: Results From Patient and Clinician Survey (Preprint)
Authors: Jain Neha
Published: July 2022

BACKGROUND

Telepsychiatry has become much more widely established due to the public health emergency posed by the COVID-19 pandemic.

OBJECTIVE

This study aimed to discuss the telepsychiatry model adopted at UConn Health and explore the success of this model.

METHODS

We conducted anonymous surveys of both psychiatry clinicians as well as patients, collecting information on their satisfaction with telepsychiatry visits.

RESULTS

We found that telepsychiatry visits were widely accepted by both clinicians and patients, including older adults.

CONCLUSIONS

Telepsychiatry is a valuable way to increase access to care and is widely accepted by both clinicians and patients.
Using a Digital Approach to Improving Mental Health in Adults With Self-reported Psoriasis: An Analysis of Real-world User Data (Preprint)
Authors: Boucher Eliane , Honomichl Ryan , Zucker Murray
Published: July 2022

BACKGROUND

Visible scales and perceived stigma often lead to feelings of embarrassment, shame, low self-esteem, and self-consciousness among people with psoriasis. Beyond the negative effects of this distress on mental health, some researchers also argue that the inflammatory response caused by psoriasis predisposes patients with psoriasis to mental health conditions like depression. Given that anxiety and depression are linked to higher disease activity and pain in patients with psoriasis, researchers have argued that an important component of any psoriasis management plan should include addressing mental health. However, a shortage of mental health professionals, particularly in low income and rural areas, makes access to mental health care more challenging than many other common referrals—a problem that has been exacerbated in light of the COVID-19 pandemic.

OBJECTIVE

This study aims to explore the feasibility of using a digital mental health intervention to help improve subjective well-being and anxiety among adults with self-reported psoriasis.

METHODS

Real-world users who signed up for the digital wellness program, Happify, between January 1, 2017, and June 10, 2021, and who reported having psoriasis during onboarding were included in this analysis. To qualify, users had to complete at least two in-app assessments (which include a proprietary measure of subjective well-being, the Happify Scale, and the Generalized Anxiety Disorder 2 scale to measure anxiety), complete at least 1 Happify activity, complete no more than 3 activities before taking their first assessment, and had to have at least 42 days between their first and last assessment. We examined changes in well-being and anxiety among these participants based on Happify use (recommended vs less than recommended).

RESULTS

Users who engaged with the program at the recommended level experienced significantly greater improvements in both well-being (P<.001) and anxiety (P=.01). More specifically, users who completed the recommended number of activities improved their well-being scores by 26.8%, whereas users who completed fewer activities improved their well-being scores by only 4.11%. Similarly, users who completed the recommended number of activities improved their anxiety scores by 26.64%, compared to 8.15% among those who engaged below the recommended level.

CONCLUSIONS

These data suggest that a digital mental health intervention can effectively improve both subjective well-being and anxiety among patients with psoriasis when used at the recommended level. Although future research is required to better understand whether this subsequently impacts disease-specific outcomes, such as disease activity and pain, our data suggest that a digital approach may be one method of providing greater access to mental health support for patients with psoriasis, increasing the likelihood that it can be incorporated into their treatment plan.
The Efficacy of Lumbar Support on Pain, Disability, and Motor Control in Women With Postpartum Pelvic Girdle Pain: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Jafarian Fahimeh-Sadat , Jafari-Harandi Mahmonir , Yeowell Gillian , Sadeghi-Demneh Ebrahim
Published: July 2022

BACKGROUND

Pregnancy-related posterior pelvic girdle pain (PPGP) is one of the most important clinical manifestations of postpartum back pain. Those affected often complain of discomfort during daily activities. It is hypothesized that altered motor control is associated with perceived pain. Pelvic support can regulate possible underlying altered motor control mechanisms and decrease pain. However, the influence of a lumbosacral orthosis, which is broader support that allows for a wider contact area and more skin sensory stimulation to restore proper motor function, has not yet been investigated in women with postpartum PPGP.

OBJECTIVE

This study investigates the efficacy of broader lumbar support and narrower pelvic support on pain, proprioception, disability, and muscle strength in women with pregnancy-related PPGP.

METHODS

This study will be a single-center, 3-armed, participant-blinded, randomized controlled trial. In total, 84 women diagnosed with pregnancy-related PPGP will be recruited and randomly assigned into 3 groups. Intervention groups A and B will receive pelvic and lumbar supports, respectively. Group C (control) will receive only a patient education leaflet containing advice on strengthening exercises, comfortable positions, and other practical information. The study outcomes are pain, effort score during the active straight leg raising test, maximum isometric hip flexion force, maximum isometric hip external rotation force, maximum isometric trunk rotation force, and joint position reproduction of hip abduction. The study outcomes will be measured at 4 time points: baseline (T1), immediately after the intervention (T2), 4 weeks following interventions began (at this time, the intervention period is completed) (T3), and 1 week after discontinuing the interventions (T4) to evaluate the possible lasting effects of wearing supports. Multivariate analysis of variance will be used to test between- and within-group differences.

RESULTS

Recruitment for this study will be started in summer 2022 and is expected to be completed by the end of fall 2022.

CONCLUSIONS

This study will examine the efficacy of broader lumbar support as an early rehabilitative treatment for women receiving postpartum posterior pelvic pain support compared to those receiving a narrower pelvic support. We expect the broader lumbar support to impact pain management and disability better than the current narrower pelvic belt. Long-term follow-up studies will help determine whether such lumbosacral orthosis reduces pain and improves daily activities in women with pregnancy-related PPGP.

CLINICALTRIAL

Iranian Registry of Clinical Trials IRCT20150210021034N11; https://www.irct.ir/trial/54808

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/40553
Study Protocol for a Randomized Controlled Trial of Grocery Delivery to Support Healthy Weight Gain among Pregnant Young Women with Low-Income (Preprint)
Authors: Waselewski Marika , Plegue Melissa , Sonneville Kendrin , Resnicow Kenneth , Ghumman Aisha , Ebbeling Cara , Mahmoudi Elham , Sen Ananda , Wolfson Julia , Chang Tammy
Published: July 2022

BACKGROUND

Excessive weight gain during pregnancy is associated with complications for both the mother and her infant including gestational diabetes, hypertensive disorders, operative delivery, and long-term obesity. Healthy diet during pregnancy promotes healthy gestational weight gain and determines fetal epigenetic programming in infants that impacts risk for future chronic disease.

OBJECTIVE

This project will examine the impact of grocery delivery during pregnancy on the weight, diet, and health outcomes for young pregnant women and their infants.

METHODS

A three arm randomized controlled trial design will be performed. 855 young pregnant women, aged 14-24, from across the state of Michigan will be enrolled and randomized equally into the three study arms. Participants in arm one (control) will receive usual care from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), arm two will receive WIC plus biweekly grocery delivery, and arm three will receive WIC plus biweekly grocery and unsweetened beverage delivery. Weight will be assessed weekly during pregnancy and total pregnancy weight gain will be categorized as above, below, or within guidelines. Additionally, dietary intake will be assessed at three time points (baseline, 2nd trimester, 3rd trimester) and pregnancy outcomes will be extracted from medical records. Appropriateness of pregnancy weight gain, diet quality, and occurrence of poor outcomes will be compared between groups using standard practices for multinomial regression and confounder adjustment.

RESULTS

This study was funded in April 2021, data collection started in December 2021, and data collection is expected to be concluded in 2026.

CONCLUSIONS

This study will test whether grocery delivery of healthy foods improves weight, diet, and pregnancy outcomes in young moms with low-income. Findings will inform policies and practices that promote a healthy diet during pregnancy, which has multi-generational impacts on health.

CLINICALTRIAL

ClinicalTrials.gov: NCT05000645. Registered August 11, 2021