bluuebunny/crossref_metadata_2025 huggingface dataset:
Indirect comparison of 48-week efficacy and safety of long-acting cabotegravir and rilpivirine maintenance every 8 weeks with daily oral standard of care antiretroviral therapy in participants with virologically suppressed HIV-1-infection
Authors: Chounta Vasiliki , Snedecor Sonya J , Wu Sterling , Velde Nicolas Van de
Published: September 2020

BackgroundEfficacy and safety of long-acting cabotegravir (CAB) + rilpivirine (RPV) every 8 weeks (Q8W) versus daily oral standard of care (SoC) maintenance in treatment-experienced individuals with virologically suppressed human immunodeficiency virus type 1 (HIV-1) has not been directly compared in randomized clinical trials. This analysis aimed to indirectly compare these regimens. MethodsAn adjusted indirect treatment comparison of CAB + RPV Q8W with daily oral SoC was performed, using Phase 3 data from studies of CAB + RPV every 4 weeks vs SoC (Q4W; ATLAS/FLAIR, n=591 per group) and a Phase 3b trial of CAB + RPV Q8W vs Q4W (ATLAS-2M [excluding participants with prior CAB + RPV exposure]; n=327 per group). Eligible participants were virologically suppressed (viral load <50 HIV-1 ribonucleic acid (RNA) copies/mL), treatment-experienced individuals with HIV-1-infection. Treatment efficacy and safety at Week 48 included virologic suppression and lack of virologic suppression (proportion of participants with plasma HIV-1 RNA <50 copies/mL or ≥50 copies/mL, respectively; both as per FDA snapshot algorithm), CD4-cell count change from baseline, no virologic data, discontinuations due to adverse events (AEs), and overall AEs, serious AEs and Grade 3–5 AEs excluding injection-site reactions. Baseline characteristics between the Q4W arms of ATLAS/FLAIR and ATLAS-2M showed no significant differences or differences were not judged to be clinically relevant, apart from participants switching from a baseline third active drug class; more participants switched from integrase strand inhibitors in ATLAS/FLAIR, and from non-nucleoside reverse transcriptase inhibitors in ATLAS-2M. A subgroup analysis stratified by baseline third active drug class was performed. ResultsInjections of CAB + RPV Q8W showed no significant differences across efficacy and safety outcomes versus daily oral SoC. The subgroup analysis found there were no significant differences on virologic suppression or lack of virologic suppression for any baseline third active drug class subgroups. These results suggest that CAB + RPV Q8W is non-inferior to daily oral SoC.ConclusionsThis analysis supports the therapeutic potential of CAB + RPV Q8W for virologically suppressed people living with HIV-1 infection seeking an alternative maintenance treatment option to daily oral SoC.Trial registrationNCT02938520, NCT02951052, NCT03299049
Predictive Value of Clinical Toxicities to Chemotherapy with Fluoropyrimidines and Oxaliplatin in Colorectal Cancer by DPYD and GSTP1 Genes Polymorphisms
Authors: Deng Xunwei , Hou Jingyuan , Deng Qiaoting , Zhong Zhixiong
Published: September 2020

Background: Fluoropyrimidines and platinum are still widely used for colorectal cancer (CRC) management. Several studies have reported that mutations of dihydropyrimidine dehydrogenase (DPYD) and glutathione S-transferase pi-1 (GSTP1) polymorphisms are related to Chemotherapy-related adverse events. The present study was aimed to determine the role of DPYD and GSTP1 variants on patient chemotherapy toxicity risk among the Hakka population, minimize adverse events and in order to maximize therapy outcome for individualized treatment.Methods: Genotyping was examined in 104 patients diagnosed with CRC cases and receiving fluoropyrimidine and platinum drugs based chemotherapy regimen by direct sequencing of DPYD and GSTP1 polymorphisms. Three DPYD variants including *2A, *5A, *9A and GSTP1 c.313A>G were analyzed and clinical outcomes were assessed. Results: The data suggest that the incidence of DPYD*5A, DPYD*9A and GSTP1 c.313A>G variants were 37.5%, 24% and 31.7%, respectively. DPYD*2A variant was not found. A total of 38 patients (36.5%) suffered severe neutropenia and 23 patients (22.1%) suffered severe vomiting. DPYD*5A polymorphism was found significantly associated with grade 3/4 ulceration (p = 0.001). GSTP1 was determined to be an independent risk factor for severe neutropenia and ulceration (p = 0.010 and p = 0.034, respectively). Patients with GSTP1 c.313A>G wild type contributed to higher risk for grade severe toxicity compared with A/G + G/G genotype (p = 0.024). However, there was no significant difference between patients with DPYD*9A T/T and T/C + C/C genotype for chemotherapeutic toxicity.Conclusions: The results demonstrated that DPYD*5A and GSTP1 polymorphisms were useful predictors for severe events. Screening of single nucleotide polymorphisms of DPYD and GSTP1 in colorectal cancer patients prior to chemotherapy may help to realize personalized therapy.
Solar-to-hydrogen peroxide energy conversion on resorcinol-formaldehyde resin photocatalysts prepared by acid-catalysed polycondensation
Authors: Shiraishi Yasuhiro , Hagi Takumi , Matsumoto Masako , Tanaka Shunsuke , Ichikawa Satoshi , Hirai Takayuki
Published: September 2020

The photocatalytic generation of hydrogen peroxide from water and dioxygen (H2O + 1/2O2 → H2O2, ΔG° = +117 kJ mol-1) under sunlight is a promising strategy for the artificial photosynthesis of a liquid fuel. We had previously found that resorcinol-formaldehyde (RF) resin powders prepared by the base-catalysed high-temperature hydrothermal method act as semiconductor photocatalysts for H2O2 generation. Herein, we report that RF resins prepared by the acid-catalysed high-temperature hydrothermal method (~523 K) using common acids at pH < 4 exhibit enhanced photocatalytic activity. The base- and acid-catalysed methods both produce methylene- and methine-bridged resins consisting of π-conjugated and π-stacked benzenoid-quinoid donor-acceptor resorcinol units. The acidic conditions result in the resins with a lower bandgap (1.7 eV) and higher conductivity because the lower degree of crosslinking creates a strongly π-stacked architecture. The irradiation of the RF-acid resins with simulated sunlight in water with atmospheric-pressure O2 generates H2O2 at a solar-to-chemical conversion efficiency of 0.7%, which is the highest efficiency ever reported for powder catalysts used in artificial photosynthesis.
Application of Ultrasound-Guided Intranodal Lymphangiography and Embolization in Cancer Patients With Postoperative Lymphatic Leakage
Authors: Sun Xingwei , Zhou Feng , Bai Xuming , Yuan Qiang , Zhang Mingqing , Ma Liang , Jin Yong
Published: September 2020

Background: Traumatic lymphatic leakage is a rare but potentially life-threatening complication. The purpose of this study was to introduce the technique of ultrasound-guided intranodal lymphangiography and embolization in the postoperative lymphatic leakage in patients with cancer.Methods: During January 2018 and June 2020, seven cancer patients (three males, four females, aged 59-75 years [mean 67.57 ± 6.11 years]) developed lymphatic leakage after abdominal or pelvic surgery, with drainage volume ranging from 550 to 1200 mL per day. The procedure and follow-up of ultrasound-guided intranodal lymphangiography and embolization were recorded. This study retrospectively analysed the technical success rate, operation time, hospital stay, clinical efficacy, and complications.Results：The operation was technically successful in all patients. Angiography revealed leakage and embolization was performed in all the seven patients (7/7, 100%). The operative time of angiography and embolization was 41 to 68 minutes, with an average time of 53.29 ± 10.27 minutes. The mean length of stay was 3.51±1.13 days. Lymph node embolization was finally clinically successful in five patients (5/7, 71.43%), with a significant reduction in or disappearance of chylous ascites. The other two patients received surgical treatment 2 weeks later due to poor results after embolization. All patients were followed-up for 2 weeks. No serious complications or only minor complications were found in all the patients.Conclusions：Ultrasound-guided intranodal lymphangiography and embolization are easy to tolerance, with a low incidence of complications. Early intervention is recommended for cancer patients with postoperative lymphatic leakage.
Application of the ACOSOG Z0011 Criteria to Chinese Patients with Breast Cancer: A Prospective Study
Authors: Peng Yuan , Liu Miao , Tong Fuzhong , Cao Yingming , Liu Peng , Zhou Bo , Liu Hongjun , Cheng Lin , Guo Jiajia , Xie Fei , Yang Houpu , Wang Siyuan , Wang Chaobin , Wang Shu
Published: September 2020

Background: Although the ACOSOG Z0011 study showed axillary lymph node dissection (ALND) could be avoided in a specific population of sentinel lymph node positive patients, it’s not widely accepted by Chinese surgeons. We conducted a prospective single-arm study to confirm whether or not the results of Z0011 are applicable to Chinese patients. Methods: Patients conforming to the Z0011 criteria were prospectively enrolled at the Peking University People’s Hospital Breast Center from November 2014 to June 2019. Clinicopathological features of the study group were compared with the Z0011 study. Lymphedema after surgery, incidence of local-regional recurrence, and survival were analyzed. Results: One hundred forty-two patients who met Z0011 eligibility criteria were enrolled in this study; 115 had sentinel lymph node biopsy (SLNB) alone. When comparing with the Z0011 trial, younger patients were included (median age, 52 [26- 82] years vs 54 [25-90] years; P = 0.03). Among clinical T stage, tumor histology, hormone status, lymphovascular invasion, and the number of positive sentinel lymph nodes (SLNs), no statistically significant differences were observed. More patients received adjuvant chemotherapy and endocrine therapy (90.85% vs 58.0% and 80.99% vs 46.6% respectively, P < .001). A similar percentage of patients received radiotherapy, but more nodal radiotherapy procedures were carried out in our study (54.5% vs 16.9%). After median follow-up of 29 months, only 1 patient (0.9%) had ipsilateral breast tumor recurrence and no regional recurrence occurred. Conclusion: Our study showed that it is achievable to avoid ALND in patients eligible for Z0011 in China. Trial registration: ClinicalTrials Registered Number: NCT03606616. Registered 31 July 2018-Retrospectiverly registered, https://www.clinicaltrials.gov/ct2/show/NCT03606616?term=Wang+shu&draw=4&ra nk=21.
Non-O Blood Group is Associated With a Higher Risk of Dyslipidaemia Amongst French Women
Authors: MacDonald Conor , Madika Anne-Laure , Severi Gianluca , Fournier Agnes , Boutron-Ruault Marie-Christine
Published: September 2020

IntroductionThe non-O blood groups have previously been associated with higher risk of cardiovascular disease in prospective cohort studies. While cross-sectional studies have identified higher serum cholesterol amongst A-group individuals, there is no evidence from prospective studies whether this translates into a higher risk of dyslipidaemia that requires treatment. This study aimed to prospectively determine potential associations between ABO blood groups and risk of incident dyslipidaemia requiring treatment.MethodsWe assessed associations between blood ABO group and dyslipidaemia in women participating in the E3N cohort. We included women who did not have cardiovascular disease at baseline. We used logistic regression to determine associations between ABO group and prevalent dyslipidaemia at baseline. Cox proportional hazard models were used to determine if blood ABO group was associated with an increased risk of incident dyslipidaemia, controlling for potential confounding.ResultsAt baseline, 55,512 women were included, and 10,058 incident cases of dyslipidaemia were identified at a rate of 17.6/1,000 PY. Of these participants, 24,510 reported being of the O-group, and 31,002 of non-O. Non-O blood groups were associated with prevalent dyslipidaemia (OR = 1.17 [1.13: 1.21]). The non-O blood groups were associated with an increased risk of dyslipidaemia (HR non-O = 1.14 [1.10: 1.19]), specifically the A group (HRA = 1.18 [1.13: 1.23]). Interactions with smoking were considered possible (p-interaction = 0.06), with AB smokers showing the highest risk of dyslipidaemia (HRAB smokers = 1.54 [1.12: 2.11]).ConclusionNon-O blood group, specifically the A group were associated with a moderately increased risk of dyslipidaemia.
A social media-based study on the psychological impact of COVID-19 infections in recovered and recovering patients
Authors: Kumar Vikesh , Varshney Mohit , Singh Harmandeep , Singh Amandeep , Baker Julien S.
Published: September 2020

AbstractObjective: The WHO has stressed to regularly monitor the mental health of populations during the COVID-19 pandemic. As a result, we conducted this study to examine anxiety and depression among recovered and recovering COVID-19 patients. Subjects and Methods: An online survey was conducted using a social media platform from 31/05/2020 to 24/06/2020. The study participants were COVID-19 infected individuals who had recovered or still were in the recovery phase from COVID-19. We collected information on demographics, clinical characteristics and physical complications of COVID-19. Anxiety and depressive symptoms were assessed using previously validated tools. Descriptive statistics and logistic regression were applied to analyze the data. Results: 53.4% of respondents reported that they had a fear of getting COVID-19 again. Anxiety and depressive symptoms were present in 71.7% and 97.6% of respondents respectively. Both disorders were present in 71.3% of respondents. The respondents with shorter durations of physical symptoms (< 2 weeks) demonstrated less anxiety (OR = 0.19; 95% CI: 0.05 - 0.67) and depression (OR = 0.03; 95% CI: 0.01 - 0.37). Conclusion: Anxiety and depression appear as common psychological complications in COVID-19 recovering and recovered patients. Longer durations of COVID-19 related physical symptoms were associated with an increased likelihood of anxiety and depression.
The Role Sol-gel Method and Doping Ba in the Drastic Reduction of the Annealing Time and the Improvement of the Coupling Between Grains of Bi1.6Pb0.4 Sr2-xBaxCa2Cu3Oy Superconductor 
Authors: Ghahfarokhi seyed ebrahim Mousavi , Zamani Saeedeh
Published: September 2020

In this study, the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy superconductors with x = 0.0, 0.05, 0.1, 0.15, 0.2, 0.25, and 0.3 were synthesized at annealing times of 32, 48, 64 h using a sol-gel method. Then, the effect of Ba doped, the annealing times, ac magnetic fields and frequencies in the improvement of the coupling between grains of the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy (BPSBCC) superconductors were studied. In order to determine annealing temperature, TGA analysis of x = 0.0 was performed. The structural and ac magnetic susceptibility prepared samples were characterized using an X-ray diffraction, an ac susceptometer and scanning electron microscopy (SEM). The results of ac magnetic susceptibility and structural of the samples indicated that the improvement of the coupling between grains and the stability of the Bi1.6Pb0.4Sr2-xBaxCa2Cu3Oy superconductors with value of x = 0.2 at 845 °C for 48 h have been increased.
Collaborative Involvement of Indigenous Youth in the Design and Evaluation of Digital Mental Health Interventions: A Scoping Review Protocol
Authors: Povey Josie , Raphiphatthana Buaphrao , Torok Michelle , Nagel Tricia , Shand Fiona , Sweet Michelle , Lowell Anne , Dingwall Kylie
Published: September 2020

Background: Indigenous youth worldwide are at greater risk of developing mental health concerns due to ongoing inequity and disadvantage. Digital mental health solutions are identified as a potential approach to improving access to mental health treatment for Indigenous youth, with evidence of acceptability and effectiveness beginning to emerge. Although collaborative design, development and evaluation is widely recognised as necessary to improving the acceptability of these tools, there is limited evidence to guide engagement of Indigenous youth in these processes. The objective of this scoping review is to map evidence regarding the collaborative involvement of Indigenous youth in the design and/or evaluation of digital mental health interventions. Methods: Scoping review methodology includes six stages, 1) identifying research question; 2) identifying relevant studies; 3) developing a study selection and data extraction method; 4) charting the data; 5) collating, summarising and reporting results. Additionally, Step 6) consultation, engages a male and female Indigenous health researcher in reviewing protocols, analysis and findings, enhancing credibility and ensuring findings are informed by Indigenous worldviews. Searches for relevant literature are undertaken in the following databases: EBSCOhost databases (Academic Search Premiere, Computer and Applied Science complete, CINAHL Plus with Full text, MEDLINE with full text, APA PsychArticles, Psychology and Behavioural Sciences collection, APA PsychInfo), PubMed, and Scopus. In addition, Infomit and Google (limited to the first 200 results) are searched for grey literature. All primary studies and grey literature in English that meet eligibility criteria are included. Data, including; study methods, methodologies, digital mental health program details, participant information and engagement and reporting processes are extracted and included for analysis. Data extraction variables are guided by the Consolidated Criteria for Strengthening Reporting of Health Research (CONSIDER statement). This statement provides a best practice checklist for reporting research involving Indigenous peoples. This scoping review protocol has been registered with Open Science Framework (available via osf.io/2nkc6).Discussion: To date, there are no reviews which critically analyse engagement of Indigenous youth in the development and evaluation of youth-specific digital mental health interventions. This review will aim to fill that gap and appraise alignment of current practice with best practice guidelines to inform future research. It will highlight appropriate strategies for the engagement of youth in collaborative processes, providing guidance for health practitioners, policy makers, and researchers working in the field of Indigenous youth and digital mental health.
Text in Diagrams
Authors: Schulze Christoph Daniel
Published: September 2020

Visual programming languages based on node-link diagrams are supposedly easy to use and to understand.
This is only true, however, if the diagram elements are properly placed - a tedious and time-consuming process if done manually.
Automatic graph layout algorithms alleviate users from that burden.
Since even visual languages usually cannot make do without text,
it follows that layout algorithms need to properly support textual labels. That is what this work is all about.
We start by examining how enough space can be reserved for textual labels to be properly placed without overlaps.
We then look at how users place comments in diagrams to establish relations to diagram elements.
Our aim is to infer those, in order to take them into account during layout. We finally look at the negative implications of too much text:
large diagrams and too much information. Different label management strategies dynamically change the text of labels,
thus changing their size and, optionally, the amount of text displayed. All of the techniques are evaluated according to aesthetic criteria,
and most are also validated through user studies.
Document-Engineering Methodology in Health Care: An Innovative Behavioral Science–Based Approach to Improve Patient Empowerment
Authors: Pohlmann-Eden Bernd , Eden Silke C
Published: September 2020

Engaging patients in their treatment and making them experts of their condition has been identified as a high priority across many medical disciplines. Patient empowerment claims to improve compliance, patient safety, and disease outcome. Patient empowerment may help the patient in shared decision making and in becoming an informed partner of the health care professional. We consider patient empowerment to be in jeopardy if written medical information for patients is too complex and confusing.
We introduce document-engineering methodology (DEM) as a new tool for the health care industry. DEM tries to implement principles of cognitive science and neuroscience-based concepts of reading and comprehension. It follows the most recent document design techniques. DEM has been used in the aviation, mining, and oil industries. In these very industries, DEM was integrated to improve user performance, prevent harm, and increase safety.
We postulate that DEM, applied to written documents in health care, will help patients to quickly navigate through complex written information and thereby enable them to better comprehend the essence of the medical information. DEM aims to empower the patient and help start an informed conversation with their health care professional. The ultimate goals of DEM are to increase adherence and compliance, leading to improved outcomes.
Our approach is innovative, as we apply our learning from other industries to health care; we call this cross-industry innovation. In this manuscript, we provide illustrative examples of DEM in three frequent clinical scenarios: (1) explaining a complex diagnosis for the first time, (2) understanding medical leaflet information, and (3) exploring cannabis-based medicine. There is an urgent need to test DEM in larger clinical cohorts and for careful proof-of-concept studies, regarding patient and stakeholder engagement, to be conducted.
Blog Posting After Lung Cancer Notification: Content Analysis of Blogs Written by Patients or Their Families
Authors: Sato Akira , Aramaki Eiji , Shimamoto Yumiko , Tanaka Shiro , Kawakami Koji
Published: September 2020

Background

The advent and spread of the Internet has changed the way societies communicate. A portion of information on the Internet may constitute an important source of information concerning the experiences and thoughts of patients and their families. Patients and their families use blogs to obtain updated information, search for alternative treatments, facilitate communication with other patients, and receive emotional support. However, much of this information has yet to be actively utilized by health care professionals.

Objective

We analyzed health-related information in blogs from Japan, focusing on the feelings and satisfaction levels of lung cancer patients or their family members after being notified of their disease.

Methods

We collected 100 blogs written in Japanese by patients (or their families) who had been diagnosed with lung cancer by a physician. These 100 blogs posts were searchable between June 1 and June 30, 2013. We focused on blog posts that addressed the lung cancer notification event. We analyzed the data using two different approaches (Analysis A and Analysis B). Analysis A was blog content analysis in which we analyzed the content addressing the disease notification event in each blog. Analysis B was patient's dissatisfaction and anxiety analysis. Detailed blog content regarding patient's dissatisfaction and anxiety at the individual sentence level was coded and analyzed.

Results

The 100 blog posts were written by 48 men, 46 women, and 6 persons whose sex was undisclosed. The average age of the blog authors was 52.4 years. With regard to cancer staging, there were 5 patients at Stage I, 3 patients at Stage II, 14 patients at Stage III, 21 patients at Stage IV, and 57 patients without a disclosed cancer stage. The results of Analysis A showed that the proportion of patients who were dissatisfied with the level of health care exceeded that of satisfied patients (22% vs 8%). From the 2499 sentences in the 100 blog posts analyzed, we identified expressions of dissatisfaction and anxiety in 495 sentences. Our results showed that there were substantially more posts concerning “Way of living, reasons for living, set of values” and “Relationships with medical staff (own hospital)” than in previous studies (Analysis B).

Conclusions

This study provides insight into the feelings of dissatisfaction and anxieties held by lung cancer patients and their families, including those regarding the “Way of living, reasons for living, set of values” and “Relationship with medical staff (own hospital),” which were inaccessible in previous survey analyses. When comparing information obtained from patients’ voluntary records and those from previous surveys conducted by health care institutions, it is likely that the former would be more indicative of patients’ actual opinions and feelings. Therefore, it is important to utilize such records as an information resource.
Global Outreach of a Locally-Developed Mobile Phone App for Undergraduate Psychiatry Education
Authors: Zhang Melvyn WB , Cheok Christopher CS , Ho Roger CM
Published: September 2020

Background

Over the past decade, there have been massive developments in both Web-based and mobile phone technologies. Mobile phones are well accepted by students, trainees, and doctors. A review of the current literature has identified the following specialties that have used mobile phones in education: pediatrics, ophthalmology, nephrology, plastic surgery, orthopedics, pharmacology, and urology. However, to date, there are no published papers examining the application of the latest mobile phone technologies for psychiatry education internationally.

Objectives

The main objectives of this study are (1) to determine the feasibility and receptiveness of a locally-developed psychiatry mobile phone app and user perspectives (both quantitative and qualitative) towards it, and (2) to determine the receptiveness of a locally-developed app for psychiatry education internationally.

Methods

A Web-based app that contained textbook contents, videos, and quizzes was developed using HTML5 technologies in 2012. Native apps were subsequently developed in 2013. Information about the apps was disseminated locally to Singaporean medical students, but the respective native apps were made available on the app stores. A user perspective survey was conducted locally to determine student’s perception of the app.

Results

From the inception of the app until the time of preparation of this manuscript, there have been a cumulative total of 28,500 unique visits of the responsive HTML5 Web-based mobile phone app. There have been a cumulative total of 2200 downloads of the Mastering Psychiatry app from the Apple app store and 7000 downloads of the same app from the Android app store. The initial user perspective survey conducted locally highlighted that approximately a total of 95.2% (177/186) of students felt that having a psychiatry mobile phone app was deemed to be useful. Further chi-squared analysis demonstrated that there was a significant difference between males and females in their perception of having textbook contents in the mobile phone app (χ24=12.9, P=.0012).

Conclusions

To the best of our knowledge, this is the first study to demonstrate the feasibility and global acceptance of a local, self-designed educational app for psychiatry education. Whilst the current research has managed to demonstrate the feasibility and acceptance of such an app, future studies would be warranted to look, in-depth, into whether there are cultural differences in terms of perceptions towards having such an app in psychiatry and what contents different cultures and cohorts of students might want within an app.
Health related quality of life of rosacea patients in China assessed by DLQI and willingness to pay: Cross-Sectional Questionnaire Study (Preprint)
Authors: Huang Yaqun , Yan Sha , Xie Hongfu , Wang Ben , Zhao Zhixiang , Huang Yingxue , Li Ji
Published: September 2020

BACKGROUND

Rosacea is a chronic inflammatory dermatosis with facial skin involved, leading to physical and emotional problems, which greatly affected quality of life (QoL) of patients. Dermatology Life Quality Index (DLQI) and willingness to pay (WTP) are well-established instruments assessing the health-related quality of life (HRQoL), while very few studies have been focused on this topic about rosacea in China.

OBJECTIVE

To investigate HRQoL in Chinese rosacea patients assessed by DLQI and WTP and investigate potential predictors for patients with HRQoL severely affected.

METHODS

This cross-sectional study was conducted on 973 patients with rosacea. Sociodemographic data, clinical features and DLQI were collected, and WTP was assessed by three standardized items. Multivariable logistic analysis was performed to investigate independent factors influencing QoL.

RESULTS

921 questionnaires were accomplished by participants. The mean DLQI score was 11.6 (median 11). Patients were willing to pay an average of $1050.2 or € 896.2 (median $431.4 or € 368.1) for complete cure. 33.3% would like to pay more than 20% of their monthly income to achieve sustainable control. There were positive correlations between WTP with DLQI (P < .05). DLQI could be independently impacted by age (21-30 and 31-40, OR = 3.242 and 3.617, respectively), the occupational requirement of appearance (high, OR = 4.410), disease duration (< 2 years, OR = 1.582), oedema (OR = 1.844) and severity of flushing, burning, stinging and pruritus (severe, OR = 2.003, 1.981, 2.491, 2.249, respectively). There were no significant associations between WTP and most of the clinical factors.

CONCLUSIONS

The QoL was negatively affected and should not be ignored among rosacea patients in China. Patients aged 21-40y, having occupational requirement of appearance, with the disease duration less than 2 years, and suffering severe flushing and related symptoms were more likely to have severe or very severe limitation of QoL.
Informed Choice for Participation in Down Syndrome Screening: Development and Content of a Web-Based Decision Aid
Authors: Skjøth Mette Maria , Hansen Helle Ploug , Draborg Eva , Pedersen Claus Duedal , Lamont Ronald F , Jørgensen Jan Stener
Published: September 2020

Background

In Denmark, all pregnant women are offered screening in early pregnancy to estimate the risk of having a fetus with Down syndrome. Pregnant women participating in the screening program should be provided with information and support to allow them to make an informed choice. There is increasing interest in the use of Web-based technology to provide information and digital solutions for the delivery of health care.

Objective

The aim of this study was to develop an eHealth tool that contained accurate and relevant information to allow pregnant women to make an informed choice about whether to accept or reject participation in screening for Down syndrome.

Methods

The development of the eHealth tool involved the cooperation of researchers, technology experts, clinicians, and users. The underlying theoretical framework was based on participatory design, the International Patient Decision Aid Standards (IPDAS) Collaboration guide to develop a patient decision aid, and the roadmap for developing eHealth technologies from the Center for eHealth Research and Disease Management (CeHRes). The methods employed were a systematic literature search, focus group interviews with 3 care providers and 14 pregnant women, and 2 weeks of field observations. A qualitative descriptive approach was used in this study.

Results

Relevant themes from pregnant women and care providers with respect to information about Down syndrome screening were identified. Based on formalized processes for developing patient decision aids and eHealth technologies, an interactive website containing information about Down syndrome, methods of screening, and consequences of the test was developed. The intervention was based on user requests and needs, and reflected the current hospital practice and national guidelines.

Conclusions

This paper describes the development and content of an interactive website to support pregnant women in making informed choices about Down syndrome screening. To develop the website, we used a well-structured process based on scientific evidence and involved pregnant women, care providers, and technology experts as stakeholders. To our knowledge, there has been no research on the combination of IPDAS standards and the CeHRes roadmap to develop an eHealth tool to target information about screening for Down syndrome.
Preparing for COVID-19: The lessons from SARS 2003 in Canada
Authors: White David
Published: September 2020

What is Covid-19?

Definition: COVID-19 is the infectious disease caused by the most recently discovered coronavirus. It was first recognized in Wuhan, China, in December 2019.

Symptoms: The most common symptoms are fever, tiredness, and dry cough. Some people may have aches and pains, nasal congestion, runny nose, sore throat or diarrhea.

Course: Symptoms usually begin gradually. Some people become infected but don’t develop any symptoms. Most people (about 80%) recover from the disease without needing special treatment. Around 1 out of every 6 people becomes seriously ill and develops difficulty breathing.

At risk: Older people, and those with underlying medical problems. People with fever, cough and difficulty breathing should seek medical attention.
The model and elements of palliative care for patients with terminal illness: A systematic review
Authors: Arisanti Nita , F Hadisoemarto Panji , Pudji Setiawati Sasongko Elsa , Pandia Veranita , Hilmanto Dany
Published: September 2020

Backgorund: Many models of palliative care have already been implemented, however, a model of health care cannot be directly applied in a country because of the differences in socio-cultural, disease patterns and health systems within the country. This study aimed to conduct a systematic review to analyze models of palliative care and elements of model for palliative care. 

Methods: A systematic review was conducted. Articles were searched by four electronic databases; PubMed, Web of Science, Ovid and NICE Database. Three reviewers screened the search results and data were classified according to their main objective. Further synthesize was conducted to show element and model of care. 

Results: The initial search strategy identified 218. Based on Hawker quality assessment scale, only 14 articles met criteria for review and synthesis. Out of 14, 4 articles describe palliative care for chronic disease (heart failure, end stage renal disease) and 10 for cancer. The integrated palliative care model has been the most frequently described. The other models are respite care, care-aide and personal alarm model, family centered advanced care, and end of life care for young adults. This systematic review also identified elements of model for palliative care and categorized as element from patient and family, personnel and health care system.

Conclusion: A few studies are describing a model of palliative care and elements of model for palliative care in detail. More detailed methodological and population specifications are needed to accurately find the results.
What Are the Basic Units of Society? A Micro Discussion
Authors: Lane Jan-Erik
Published: September 2020

The hunt is on for finding the most basic UNITS of matter and the universe whatever that may be: quarks, strings or quantum waves. There is one major condition, namely this theory must agree with the relativistic predictions about macro cosmos. How about the Humanities and the Social Sciences: what is the micro level like? Max Weber focused on intention.
Kajian Ekstraksi Karagenan Berdasarkan Variasi Rasio Rumput Laut (Eucheuma cottonii) dengan Nira Siwalan (Borrasus flaberina L.) dan Lama Perendaman serta Aplikasinya pada Bubuk Jelly Drink Nanas (Ananas comosus)
Authors: Ashfarina Alfajri Ula , Harini Noor , Hendraningsih Listiari
Published: September 2020

The extraction of carrageenan by Eucheumma cottonii using siwalan neera as a solvent which contains pottasium 236mg per 100g and others mineral. Carragenan extract applied on pineapple jelly drink powder as a gelling agent by different concentration. This research was conducted into two stages by 3 times repitition. First, carrageenan extraction using a Factorial Randomized Block Design (RBD) consisting of 2 factors. The first factor is the ratio of seaweed with neera siwalan (S) (1:10, 1:20, 1:30) and second factor is extraction time (T) (60 minutes, 90 minutes, and 120 minutes). Extract of carrageenan was analyzed on yield, viscosity, gel strength, moisture content and ash content. The second stage is application of carrageenan extract on pineapple jelly drink powder (K) with carrageenan concentration differently (K) of 0.5%, 1%, 1.5%, 2%, 2.5%. The parameters analyzed in the second stage are viscosity, gel strength, syneresis, and organoleptic (taste, suction power, and mouthfeel). The results shows that there was a significant effect on the Siwalan neera ratio on the carrageenan produced on yield, viscosity, gel strength, water content. The best carrageenan at stage 1 was produced from the treatment of seaweed and neera siwalan ratio 1:30 with extraction time of 120 minutes (S3T3), namely yield 82.87%, moisture content 15.3%, ash content 15.97%, gel strength 102.95 g/cm2 and 5,3 cP viscosity. The addition of the best extract carrageenan to pineapple jelly drink and it was obtained the best result namely the addition of carrageenan 1% (K2) with viscosity of 2.3 cP, gel strength 8.6615 g/cm2, sineresis (24 hours) 0.9183%, sineresis (48 Hours) 3.5430%, and sineresis (72 Hours) 5.1905%, taste 3.3 (enough in tasting), suction power 3.75 (easy to suck) and mouthfeel 2.9 (enough to feel the gel).
Uji Potensi Cracker dengan Tepung Kulit Bawang Merah (Allium ascalonicum) sebagai Pangan Fungsional berAntioksidan dan Antihiperkolesterolemik
Authors: Anggriani Rista , Nisa Rizki Khoirun , Rosenansi Susi Oxyvia , Purtanti Marcya Hulwatul , Warkoyo Warkoyo
Published: September 2020

Diet is one of the causes of obesity and obesity, for example by consuming foods with high cholesterol levels such as fast food or fried foods, so it is necessary to find alternative non-fried processed products that have functional properties. Cracker as a non-fried processed product is fortified with shallot skin flour which has antioxidant activity. This research purpose is to determine the effect of adding shallot skin flour (3, 5, 10%) to the cracker against total cholesterol reduction after 7 days of consumption. This research used laboratory experimental methods with pre post test design with control group. Each group consisted of 5 Wistar rats (2 control groups and 4 treatment groups) so total Wistar rats used were 30 rats. In addition, antioxidant activity was also tested. The results indicated that cracker in the P3 formula (10% fortification of shallot skin flour) had high antioxidant activity of 68.90% and was able to decrease cholesterol with the highest precentage reduction of 10% after 7 days of consumption. This cracker can be categorized as a functional food which has high antioxidants and antihypercholesterolemic activity.
PRÁTICAS LEITORAS E O USO DO INFOGRÁFICO: DA MULTIMODALIDADE AOS MULTILETRAMENTOS
Authors: Guterra Ana Lúcia Rodrigues , De Freitas Ernani Cezar
Published: September 2020

A infografia configura-se como um meio de informação utilizado cada vez mais em jornais, revistas e sites de notícias. Diante disso, este trabalho tematiza a experiência de leitura de um infográfico enquanto gênero discursivo multimodal no contexto escolar. O objetivo é analisar uma prática de leitura a partir de um exercício de aplicação de um texto multimodal no 2º ano do ensino médio de uma escola pública. O marco teórico do estudo é constituído por conceitos relacionados aos gêneros do discurso (BAKHTIN, 2016), ao letramento (LEMKE, 2010; RIBEIRO, 2011, 2016), à multimodalidade discursiva (KRESS; van LEEUWEN, 2001, 2006; DIONÍSIO, 2011, 2013) e à pedagogia dos multiletramentos (COPE; KALANTZIS, 2000; ROJO, 2009, 2012, 2013). Trata-se de um estudo exploratório realizado mediante pesquisa-ação, de cunho qualitativo e quantitativo. A hipótese é de que a utilização de infográfico como um dos gêneros discursivos multimodais promove de forma eficaz o desenvolvimento dos multiletramentos nos alunos, ampliando suas competências leitoras e os aproximando de situações sociodiscursivas próprias do seu cotidiano.
A MULTIMODALIDADE E AS MÚLTIPLAS SEMIOSES DO DIZER: A (DES)CONSTRUÇÃO DE SENTIDO EM UM ANÚNCIO PUBLICITÁRIO DO MEC
Authors: Silva Nelma Teixeira da
Published: September 2020

Este artigo tem como objetivo tecer reflexões sobre as contribuições das multissemioses para a (des)construção de sentido no gênero publicitário multimodal, a partir dos estudos sobre os multiletramentos e os novos letramentos, que compreendem o uso de múltiplas linguagens, de diversos formatos e gêneros presentes em nosso dia a dia. Para tanto, selecionamos um anúncio publicitário digital do Governo Federal, da atual gestão 2019-2022, publicado pelo Ministério da Educação (MEC) em suas redes sociais, com vistas a explicitar como a produção de sentidos é construída na propaganda, procurando apresentar uma postura crítica em relação às ações e às dominações sociais existentes, a partir de uma breve análise da linguagem multimodal. Autores como Kress e van Leeuwen (1996), Kress (2003), Knobel e Lankshear (2003, 2006, 2007), Cope e Kalantzis (2009), Dionísio (2008), Rojo e Moura (2019), Bourdieu e Boltanski (2008), dentre outros, dão suporte à discussão. Concluímos que a presença das múltiplas semioses que integram os textos contemporâneos, e, mais especificamente, o gênero publicitário possibilita a veiculação massificada de discursos intencionalmente articulados que nos convidam à reflexão e ao exercício de práticas de leitura crítica, na escola de fora dela, sendo o letramento multimodal uma possiblidade para ampliação dos (multi)letramentos, já que acionam no indivíduo mecanismos de leitura que extrapolam a materialidade do texto.
PRÁTICAS MULTILETRADAS NA FORMAÇÃO DE LEITORES NA INFÂNCIA
Authors: Machado Paulo Henrique , Rossi Remenche Maria de Lourdes
Published: September 2020

O presente estudo tem como objetivo analisar as práticas multiletradas mobilizadas por Livros Literários Infantis digitais interativos em formato de Aplicativos (LLIA) que contribuem para a formação do leitor literário na infância. Para tanto, delimitou-se como corpus de análise a obra “Wuwu & Co.: a magical picture book”, vencedora do BolognaRagazzi Digital Award (Feira do Livro Infantil de Bolonha, Itália) de 2016, na categoria ficção digital. Trata-se de pesquisa qualitativo-interpretativista, cujo arcabouço teórico-metodológico ancora-se na concepção dialógica da linguagem, elaborada pelo Círculo de Bakhtin, nos estudos dos multiletramentos e nas análises multimodais de livros digitais de literatura infantil. Verificou-se que a presença de múltiplas combinações multimodais/multissemióticas nos LLIA, aliada à agentividade do leitor e às potencialidades das tecnologias digitais, demanda maior interatividade, além de acionar modos diferenciados de leitura que contribuem para a produção de sentido.
CONSIDERAÇÕES SOBRE AQUISIÇÃO DA LINGUAGEM DE UMA CRIANÇA CIGANA CALON
Authors: Gomes de Sousa Lima Marilene , De Faria Evangelina Maria Brito
Published: September 2020

Neste artigo, buscamos compreender como uma criança cigana se insere na língua, considerando elementos verbais e não verbais que sustentam suas interações. Para tanto, nos apoiamos na concepção dialógica de língua difundida nos escritos de Bakhtin e o Círculo; bem como na ideia de que gesto e fala compõe uma única matriz de significação conforme aponta McNeill (2000, 2006), Kendon (2000), também nos fundamentamos nas contribuições de Kita (2009) que defende que há uma estreita relação entre gesto e cultura. Trata-se de uma pesquisa qualitativa, do tipo estudo de caso. Os dados foram coletados de forma naturalística por um período de oito meses em uma comunidade de ciganos Calon no sertão da Paraíba. Foram gravadas interações naturalísticas de uma criança com idade entre 16 e 24 meses em seu núcleo familiar. Trazemos para este recorte três fragmentos para ilustrar que essa criança cigana Calon adentra a língua através da matriz gesto-fala e, de forma singular, as interações são perpassadas por palavras de uma língua compartilhada entre os Calon e por gestos emblemáticos cujos sentidos são compreendidos entre os membros de sua cultura. PALAVRAS-CHAVE: Aquisição da linguagem. Multimodalidade. Relação gesto-cultura. Criança cigana Calon.
ANÁLISE CRÍTICA DO DISCURSO MULTIMODAL DE REPRESENTAÇÕES DA MULHER NA MÚSICA POP: UM ESTUDO DE CASO SOBRE A IMAGEM DINÂMICA
Authors: Bezerra Fábio Alexandre Silva , Aureliano Gomes Brenda
Published: September 2020

Este artigo, tendo como objeto de análise o videoclipe da música Mrs. Potato Head, da cantora Melanie Martinez, objetiva discutir as representações da mulher construídas por meio do texto multimodal tendo em vista suas marcas ideológicas e as relações de poder nele imbricadas. Para tal, fazemos uso de estudos em Multimodalidade e Análise Crítica do Discurso, a partir de conceitos e categorias de análise da gramática do design visual de Kress e van Leeuwen (2006), bem como do modelo tridimensional de Fairclough (2015[1989], 1995). Os resultados demostram que as representações da mulher são marcadas pelas ações e discursos de dois agentes principais: a figura masculina e a mídia, a partir da influência de visões hegemônicas sobre beleza e das relações assimétricas de poder entre homem e mulher.
A REPETIÇÃO COMO ESTRATÉGIA NA PROGRESSÃO TEMÁTICA NO ANIME O TÚMULO DOS VAGALUMES
Authors: Maria Angélica Freire de Carvalho  , De Melo Pessoa Oliveira Ana Karolina
Published: September 2020

RESUMO: Os avanços tecnológicos proporcionaram um novo modo de olhar e refletir acerca do que está no mundo, influenciando todas as áreas do cotidiano, até mesmo no que diz respeito ao ambiente escolar. O aluno do século XXI está a todo momento em contato com as novas tecnologias, bem como filmes, séries, etc. Paralelo a isto, a escola, por vezes presa a didáticas tradicionais, acaba causando desinteresse dos discentes. O trabalho, então, objetiva oferecer uma proposta que faça essa ponte entre o aluno e a sala de aula, para isso foi escolhido o gênero anime, em especial o filme O Túmulo dos Vagalumes que promove uma série de problemáticas a serem refletidas durante o período da Segunda Guerra Mundial. A metodologia da pesquisa se deu ao observar o uso das repetições dentro da animação japonesa e como estas constroem a argumentação central do enredo. Para compreender de maneira mais ampla, foi usado os estudos de Koch e Elias (2017), Carvalho (2018) sobre as repetições e o papel que desempenham, bem como a reflexão sobre animes proporcionada por Barbosa (2018). Assim, ao refletir e analisar sobre o gênero anime, como este pode ser efetivo na sala de aula e a importância dos elementos coesivos presentes, em destaque a repetição, chega-se à conclusão de que utilizar gêneros próximos aos alunos na aula promove discussões e traz o protagonismo para o aluno. PALAVRAS-CHAVE: Repetição. Sala de aula. Gênero anime.
Kevork Terzibaşyan'ın Şarkın Mistik Şiirinden Numûne veya Fuzûlî Şerhi Adlı Eser
Authors: Deveci Bozkuş Yıldız
Published: September 2020

Bu çalışmada Ermeni rahip Kevork V. Terzibaşyan’ın 1928 yılında kaleme almış olduğu Şarkın Mistik Şiirinden Numûne veya Fuzûlî Şerhi adlı eseri incelenmektedir. Fuzuli’nin hayatı, eserleri ve onun felsefi dünyasının dünya edebiyatındaki yerinin kapsamlı bir şekilde ele alındığı bu eser alanında ilk ve tek olma özelliği taşımaktadır. Terzibaşyan’ın 3 cilt olarak kaleme aldığı eserinin I. Cildinde yazarın “Selam Mustafa Kemal Paşa’ya” başlıklı bir bölüm de kaleme aldığı görülmektedir. Bu nedenle bu çalışmaya konu olan bu metin içerik açısından değerlendirilmektedir. Terzibaşyan’ın Batı Ermenice olarak kaleme alınmış olan söz konusu eseri ne yazıkki henüz Türkçeye kazandırılmamıştır. Çalışmada ilk olarak genel hatlarıyla Terzibaşyan’ın hayatı, söz konusu kiabın Türk dili ve edebiyatı açısından önemi üzerinde durulmuştur. Daha sonra Terzibaşyan’ın Fuzuli’nin hayatı ve eserlerini kapsamlı bir şekilde ele almış olduğu bir eserde Mustafa Kemal Paşa ile ilgili olarak hazırlanan bölümün içeriği değerlendirilmiştir. Bu bölümde rahip Terzibaşyan’ın kullandığı dil, üslüp ve sözcükler aracılığıyla gerek Osmanlı İmparatorluğu gerekse de Cumhuriyet dönemine bakış açısı anlaşılmaya çalışılmıştır.