bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments
Authors: Sánchez-Gomar Ismael , Geribaldi-Doldán Noelia , Santos-Rosendo Celeste , Sanguino-Caneva Ciro , Carrillo-Chapman Carlos , Fiorillo-Moreno Ornella , Villareal Camacho José Luis , Quiroz Elkin Navarro , Verástegui Cristina
Published: March 2024

Neurogenesis is the process of forming new neurons from neural stem cells (NSCs). In adults, this process takes place in specific areas of the brain, known as neurogenic niches. These regions have unique anatomical features that have been studied in animal models and in the human brain; however, there are differences between these models that need to be addressed. The most studied areas are the subventricular zone, the lateral and latero-dorsal walls of the lateral ventricles, and the dentate gyrus of the hippocampus (Hp), which are known as the canonical areas. Other, less-studied niches, such as the hypothalamus, the cerebellum, and the amygdala, are known as non-canonical areas. Anatomy occupies a relevant place in adult neurogenesis, in which the tissue architecture and cellular location are necessities for the interaction and release of diverse molecules that allow this phenomenon. The cell arrangement within the niche and the location of the niche itself are of particular relevance to the state in which the NSCs are found. Consequently, the majority of previous discoveries have been related to pathology. While many studies are based on animal models, discoveries related to neurogenesis in humans have also been made; however, in this case, opinions vary, leading to extensive controversy in recent years. In this review, we address the anatomical characteristics of the different brain regions to better understand their relationships within neurogenesis.
Bioactive Compounds from Pigmented Corn (Zea mays L.) and Their Effect on Health
Authors: Sánchez-Nuño Yaír Adonaí , Zermeño-Ruiz Martín , Vázquez-Paulino Olga Deli , Nuño Karla , Villarruel-López Angélica
Published: March 2024

Pigmented corn is a gramineae food of great biological, cultural and nutritional importance for many Latin American countries, with more than 250 breeds on the American continent. It confers a large number of health benefits due to its diverse and abundant bioactive compounds. In this narrative review we decided to organize the information on the nutrients, bioactive compounds and phytochemicals present in pigmented corn, as well as their effects on human health. Phenolic compounds and anthocyanins are some of the most studied and representative compounds in these grasses, with a wide range of health properties, mainly the reduction of pro-oxidant molecules. Carotenoids are a group of molecules belonging to the terpenic compounds, present in a large number of pigmented corn breeds, mainly the yellow ones, whose biological activity incorporates a wide spectrum. Bioactive peptides can be found in abundance in corn, having very diverse biological effects that include analgesic, opioid and antihypertensive activities. Other compounds with biological activity found in pigmented corn are resistant starches, some fatty acids, phytosterols, policosanols, phospholipids, ferulic acid and phlobaphenes, as well as a great variety of vitamins, elements and fibers. This review aims to disseminate and integrate the existing knowledge on compounds with biological activity in pigmented corn in order to promote their research, interest and use by scientists, nutrition professionals, physicians, industries and the general population.
Advances in AI for Protein Structure Prediction: Implications for Cancer Drug Discovery and Development
Authors: Qiu Xinru , Li Han , Ver Steeg Greg , Godzik Adam
Published: March 2024

Recent advancements in AI-driven technologies, particularly in protein structure prediction, are significantly reshaping the landscape of drug discovery and development. This review focuses on the question of how these technological breakthroughs, exemplified by AlphaFold2, are revolutionizing our understanding of protein structure and function changes underlying cancer and improve our approaches to counter them. By enhancing the precision and speed at which drug targets are identified and drug candidates can be designed and optimized, these technologies are streamlining the entire drug development process. We explore the use of AlphaFold2 in cancer drug development, scrutinizing its efficacy, limitations, and potential challenges. We also compare AlphaFold2 with other algorithms like ESMFold, explaining the diverse methodologies employed in this field and the practical effects of these differences for the application of specific algorithms. Additionally, we discuss the broader applications of these technologies, including the prediction of protein complex structures and the generative AI-driven design of novel proteins.
Bottlenecks in the Investigation of Retinal Sterol Homeostasis
Authors: Ramachandra Rao Sriganesh , Fliesler Steven J.
Published: March 2024

Sterol homeostasis in mammalian cells and tissues involves balancing three fundamental processes: de novo sterol biosynthesis; sterol import (e.g., from blood-borne lipoproteins); and sterol export. In complex tissues, composed of multiple different cell types (such as the retina), import and export also may involve intratissue, intercellular sterol exchange. Disruption of any of these processes can result in pathologies that impact the normal structure and function of the retina. Here, we provide a brief overview of what is known currently about sterol homeostasis in the vertebrate retina and offer a proposed path for future experimental work to further our understanding of these processes, with relevance to the development of novel therapeutic interventions for human diseases involving defective sterol homeostasis.
Protein Tyrosine Phosphatase PRL-3: A Key Player in Cancer Signaling
Authors: Liu Haidong , Li Xiao , Shi Yin , Ye Zu , Cheng Xiangdong
Published: March 2024

Protein phosphatases are primarily responsible for dephosphorylation modification within signal transduction pathways. Phosphatase of regenerating liver-3 (PRL-3) is a dual-specific phosphatase implicated in cancer pathogenesis. Understanding PRL-3’s intricate functions and developing targeted therapies is crucial for advancing cancer treatment. This review highlights its regulatory mechanisms, expression patterns, and multifaceted roles in cancer progression. PRL-3’s involvement in proliferation, migration, invasion, metastasis, angiogenesis, and drug resistance is discussed. Regulatory mechanisms encompass transcriptional control, alternative splicing, and post-translational modifications. PRL-3 exhibits selective expressions in specific cancer types, making it a potential target for therapy. Despite advances in small molecule inhibitors, further research is needed for clinical application. PRL-3-zumab, a humanized antibody, shows promise in preclinical studies and clinical trials. Our review summarizes the current understanding of the cancer-related cellular function of PRL-3, its prognostic value, and the research progress of therapeutic inhibitors.
Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease
Authors: Kamata Shotaro , Honda Akihiro , Kashiwagi Nonoka , Shimamura Ayumi , Yashiro Sayaka , Komori Yuna , Hosoda Aoi , Akahoshi Noriyuki , Ishii Isao
Published: March 2024

Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in their promoter regions. Ligand-bound PPAR/RXR complexes do not directly regulate transcription; instead, they recruit multiprotein coactivator complexes to specific genomic regulatory loci to cooperatively activate gene transcription. Several coactivators are expressed in a single cell; however, a ligand-bound PPAR can be associated with only one coactivator through a consensus LXXLL motif. Therefore, altered gene transcription induced by PPAR subtypes/agonists may be attributed to the recruitment of various coactivator species. Using a time-resolved fluorescence resonance energy transfer assay, we analyzed the recruitment of four coactivator peptides (PGC1α, CBP, SRC1, and TRAP220) to human PPARα/δ/γ-ligand-binding domains (LBDs) using eight PPAR dual/pan agonists (bezafibrate, fenofibric acid, pemafibrate, pioglitazone, elafibranor, lanifibranor, saroglitazar, and seladelpar) that are/were anticipated to treat nonalcoholic fatty liver disease. These agonists all recruited four coactivators to PPARα/γ-LBD with varying potencies and efficacy. Only five agonists (bezafibrate, pemafibrate, elafibranor, lanifibranor, and seladelpar) recruited all four coactivators to PPARδ-LBD, and their concentration-dependent responses differed from those of PPARα/γ-LBD. These results indicate that altered gene expression through consensus PPREs by different PPAR subtypes/agonists may be caused, in part, by different coactivators, which may be responsible for the unique pharmacological properties of these PPAR agonists.
Europinidin Mitigates 3-NPA-Induced Huntington’s Disease Symptoms in Rats: A Comprehensive Analysis of Oxidative Stress, Mitochondrial Enzyme Complex Activity, Pro-Inflammatory Markers and Neurotransmitter Alterations
Authors: Alharbi Khalid Saad
Published: March 2024

Huntington’s disease (HD) is a neurodegenerative disease that causes progressive motor and cognitive dysfunction. There is no cure for HD, and current therapeutics can only manage the signs and symptoms as well as slowing disease progression. This investigation examines the possible therapeutic advantages of europinidin in 3-nitropropionic acid (3-NPA) injected HD in rats. Wistar rats were randomly assigned to five groups (n = 6): normal control, 3-NPA (10 mg/kg, i.p.), 3-NPA + europinidin-10 (10 mg/kg, p.o.), 3-NPA + europinidin-20 (20 mg/kg, p.o.), and europinidin alone (20 mg/kg, p.o.) for 15-day. Various behavioral and biochemical parameters including antioxidant levels, oxidative stress, pro-inflammatory markers, mitochondrial enzyme complex, and neurotransmitters were assessed. Europinidin restored biochemical, mitochondrial dysfunction, oxidative stress, neurotransmitter, and pro-inflammatory parameters disrupted by 3-NPA. Here we show that europinidin attenuates 3-NPA-induced neurodegeneration in rat models of HD. Europinidin modulates oxidative stress, enhances antioxidants, restores mitochondrial enzyme complex activity, reduces neuroinflammation, and modulates neurotransmitter levels. Our findings reveal the potential of europinidin as a novel therapeutic agent for the treatment of HD. This study also provides new insights into the molecular mechanisms of europinidin-mediated neuroprotection and may have a beneficial role in the management of neurological diseases.
NOS1AP Gene Variants and Their Role in Metabolic Syndrome: A Study of Patients with Schizophrenia
Authors: Mednova Irina A. , Pozhidaev Ivan V. , Tiguntsev Vladimir V. , Bocharova Anna V. , Paderina Diana Z. , Boiko Anastasiia S. , Fedorenko Olga Y. , Kornetova Elena G. , Bokhan Nikolay A. , Stepanov Vadim A. , Ivanova Svetlana A.
Published: March 2024

Metabolic syndrome (MetS) is common among schizophrenia patients, and one of MetS’s causes may be an imbalance in nitric oxide regulation. In this study, we examined associations of three polymorphic variants of the nitric oxide synthase 1 adapter protein (NOS1AP) gene with MetS in schizophrenia. NOS1AP regulates neuronal nitric oxide synthase, which controls intracellular calcium levels and may influence insulin secretion. The aim of the investigation was to study polymorphic variants of the NOS1AP gene as possible markers of MetS in patients with schizophrenia. A total of 489 Caucasian patients with schizophrenia (ICD-10) from Siberia (Russia) were included in the study, and 131 (26.8%) patients had MetS (IDF classification, 2007). The participants were genotyped for three single-nucleotide polymorphisms in NOS1AP (rs12143842, rs10494366, and rs12029454). Logistic regression was used for association analysis. Single-nucleotide polymorphisms, sex, and age served as covariates; the dependent variable was the coded parameter of the presence/absence of MetS. Polymorphisms rs12143842 and rs10494366 showed a stable association even after Bonferroni’s correction for multiple comparisons (p = 0.005 and 0.002, respectively), indicating a statistically significant contribution of these polymorphic variants to the pathogenesis of MetS. Our results suggest that in patients with schizophrenia, NOS1AP may be involved in MetS pathophysiology.
Impaired Response to Mismatch Novelty in the Li2+-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs
Authors: Nascimento Carlos , Guerreiro-Pinto Vasco , Pawlak Seweryn , Caulino-Rocha Ana , Amat-Garcia Laia , Cunha-Reis Diana
Published: March 2024

Novelty detection, crucial to episodic memory formation, is impaired in epileptic patients with mesial temporal lobe resection. Mismatch novelty detection, that activates the hippocampal CA1 area in humans and is vital for memory reformulation and reconsolidation, is also impaired in patients with hippocampal lesions. In this work, we investigated the response to mismatch novelty, as occurs with the new location of known objects in a familiar environment, in the Li2+-pilocarpine rat model of TLE and its correlation with hippocampal monoaminergic markers. Animals showing spontaneous recurrent seizures (SRSs) for at least 4 weeks at the time of behavioural testing showed impaired spatial learning in the radial arm maze, as described. Concurrently, SRS rats displayed impaired exploratory responses to mismatch novelty, yet novel object recognition was not significantly affected in SRS rats. While the levels of serotonin and dopamine transporters were mildly decreased in hippocampal membranes from SRS rats, the levels on the norepinephrine transporter, tyrosine hydroxylase and dopamine-β-hydroxylase were enhanced, hinting for an augmentation, rather than an impairment in noradrenergic function in SRS animals. Altogether, this reveals that mismatch novelty detection is particularly affected by hippocampal damage associated to the Li2+-pilocarpine model of epilepsy 4–8 weeks after the onset of SRSs and suggests that deficits in mismatch novelty detection may substantially contribute to cognitive impairment in MTLE. As such, behavioural tasks based on these aspects of mismatch novelty may prove useful in the development of cognitive therapy strategies aiming to rescue cognitive deficits observed in epilepsy.
A Fish-like Binocular Vision System for Underwater Perception of Robotic Fish
Authors: Tong Ru , Wu Zhengxing , Wang Jinge , Huang Yupei , Chen Di , Yu Junzhi
Published: March 2024

Biological fish exhibit a remarkably broad-spectrum visual perception capability. Inspired by the eye arrangement of biological fish, we design a fish-like binocular vision system, thereby endowing underwater bionic robots with an exceptionally broad visual perception capacity. Firstly, based on the design principles of binocular visual field overlap and tangency to streamlined shapes, a fish-like vision system is developed for underwater robots, enabling wide-field underwater perception without a waterproof cover. Secondly, addressing the significant distortion and parallax of the vision system, a visual field stitching algorithm is proposed to merge the binocular fields of view and obtain a complete perception image. Thirdly, an orientation alignment method is proposed that draws scales for yaw and pitch angles in the stitched images to provide a reference for the orientation of objects of interest within the field of view. Finally, underwater experiments evaluate the perception capabilities of the fish-like vision system, confirming the effectiveness of the visual field stitching algorithm and the orientation alignment method. The results show that the constructed vision system, when used underwater, achieves a horizontal field of view of 306.56°. The conducted work advances the visual perception capabilities of underwater robots and presents a novel approach to and insight for fish-inspired visual systems.
Subject-Independent Emotion Recognition Based on EEG Frequency Band Features and Self-Adaptive Graph Construction
Authors: Zhang Jinhao , Hao Yanrong , Wen Xin , Zhang Chenchen , Deng Haojie , Zhao Juanjuan , Cao Rui
Published: March 2024

Emotion is one of the most important higher cognitive functions of the human brain and plays an important role in transaction processing and decisions. In traditional emotion recognition studies, the frequency band features in EEG signals have been shown to have a high correlation with emotion production. However, traditional emotion recognition methods cannot satisfactorily solve the problem of individual differences in subjects and data heterogeneity in EEG, and subject-independent emotion recognition based on EEG signals has attracted extensive attention from researchers. In this paper, we propose a subject-independent emotion recognition model based on adaptive extraction of layer structure based on frequency bands (BFE-Net), which is adaptive in extracting EEG map features through the multi-graphic layer construction module to obtain a frequency band-based multi-graphic layer emotion representation. To evaluate the performance of the model in subject-independent emotion recognition studies, extensive experiments are conducted on two public datasets including SEED and SEED-IV. The experimental results show that in most experimental settings, our model has a more advanced performance than the existing studies of the same type. In addition, the visualization of brain connectivity patterns reveals that some of the findings are consistent with previous neuroscientific validations, further validating the model in subject-independent emotion recognition studies.
Teachers’ Perceptions and Position Regarding the Problem of Bullying and Its Socio-Educational Prevention
Authors: Martínez-Carrera Sara , Sánchez-Martínez Cristina , Martínez-Carrera Isabel , Dieguez Miguel Ángel Díaz
Published: March 2024

The problems that arise with coexistence between schoolchildren are a challenge when it comes to carrying out the teaching–learning process. In recent years, the presence of bullying has increased in schools. The aim of this study is to identify the perceptions of teachers regarding the problems of coexistence among schoolchildren, more specifically concerning bullying, as well as to identify their position regarding the prevention of bullying. Research was carried out using a mixed approach. A total of 225 education professionals from different schools in Spain took part. From the results and our conclusions, it should be noted that teachers consider themselves to have a high level of knowledge of the essential characteristics of the dynamics of bullying, of the actors involved, and of some preventive measures that can be carried out to avoid this type of behaviour as much as possible. On the other hand, a large number of teachers downplay the importance of the problem of coexistence in their fields, and/or are not able to identify it, which makes it impossible to act. Some schools hardly carry out any prevention work, which makes it difficult to eradicate bullying.
Children’s Social Behaviors: Developmental Mechanisms and Implications
Authors: Ding Xuechen , Ding Wan
Published: March 2024

During the socialization process in family and school contexts, children display a wide variety of social behaviors with parents and peers. Yet the developmental trajectory, the predictors and outcomes, and the neural basis of those social behaviors are largely under-investigated. To address these problems, we invited experts in the field to submit their latest findings to tell this story. The current Special Issue is a collection of papers highlighting the complexity for various social behaviors, with a focus on the complex mechanisms that link social behaviors to child socio-emotional adjustment and mediating/moderating factors among the associations. Thirteen papers illustrate empirical work in the field, two papers present new methodological concerns, and one paper that provides a comprehensive review of the literature.
Research on the Dynamic Response of the Multi-Line Elevated Station with “Integral Station-Bridge System”
Authors: Guo Xiangrong , Wang Shipeng
Published: March 2024

Elevated stations serve as critical hubs in urban rail transit engineering. The structure of multi-line “building-bridge integrated” elevated stations is unique, with intricate force transfer paths and challenges to clarify dynamic coupling from train vibrations, necessitating the study of such stations’ train-induced dynamic responses. This paper presents a case study of a typical “building-bridge integrated” elevated station, utilizing the self-developed finite element software GSAP-V2024 to establish a simulation model of a coupled train–track–station system. It analyzed the station’s dynamic response under various single-track operating conditions and the pattern of the vibration response as the speed changes. Additionally, the study examined lateral vibration response changes in the station under double, quadruple, and sextuple train operations at the same speed. Findings reveal that the station’s vertical responses generally increase with speed, significantly outpacing lateral responses. Under single-track operations, dynamic responses vary across different types of track-bearing floors and frame structures with different spans. With an increase in the number of operating train lines, the station’s vertical response grows, with lateral responses being neutralized in the mid-span of the triple-span frame structure and amplified at the edges. These results provide a reference for the structural design of multi-line “building-bridge integrated” elevated stations.
Experimental Study on Hysteretic Performance of Steel Moment Connection with Buckling-Restrained Dog-Bone Beam Sections
Authors: Feng Shiqiang , Yang Yong , Hao Ning , Chen Xin , Zhou Jiancheng
Published: March 2024

Steel beam–column connections with dog-bone beam sections have gained significant attention and have been extensively applied. This is attributed to their ability to effectively centralize and integrate plastic hinges, thereby diverting potential damage away from the beam ends during earthquake events. In order to achieve the enhancement of the ductility and energy dissipation of connections by inhibiting local buckling during an earthquake event, a novel steel moment connection with buckling-restrained dog-bone beam sections was proposed in this paper. There were three types of proposed connections according to the different arrangements of restrained steel plates, including arranging the restrained plates only on the flanges, only on the web, and on both the flanges and webs of the dog-bone beam sections. In this study, three specimens with buckling-restrained dog-bone beam sections and one control specimen with a dog-bone beam section were tested under cyclic loading. The failure modes, hysteretic curves, skeleton curves, stiffness degradation ductilities, displacement ductility ratios, and energy dissipation capacities of the specimens were analyzed based on the experimental results to evaluate the seismic behavior of the proposed connections. The results indicated that the local buckling of the proposed connections was significantly reduced compared with the traditional connection with a dog-bone beam section under the condition of keeping the plastic hinges away from the beam–column connection core. The arrangement of the restrained plates in the dog-bone beam section had little effect on the bearing capacity and the initial stiffness, with errors all being within 6%. It is worth mentioning that the connection with restrained plates only on the flanges in the dog-bone beam sections showed a more obvious improvement in the deformation capacity and energy dissipation capacity of the connection, which increased by 21% and 16%, respectively. Additionally, high-quality welding between the beam and column, smooth cutting shapes on the weakened flanges, and the high-quality drilling of long slots at the fixed point in the restrained plates and the dog-bone beam sections should be guaranteed to improve the hysteretic stabilities of the proposed connections.
Evaluating Seismic Performance in Reinforced Concrete Buildings with Complex Shear Walls: A Focus on a Residential Case in Chile
Authors: Aguayo Ricardo , Carvallo Jorge , Vielma Juan C.
Published: March 2024

This study employs a non-linear static analysis, known as pushover analysis, to explore the flexural-compressive behavior of complex shear walls within a reinforced concrete (R.C.) structure, adhering to contemporary design standards in Chile. The primary objective is to assess the initiation of damage as the building approaches the limit states outlined in Achisina’s seminal “Performance Based Seismic Design” framework. To achieve this, a sophisticated fiber model, accounting for the confined behavior of concrete derived from the structural elements’ detailing, has been uniformly integrated across the building’s entire height. Furthermore, the analysis incorporates a rigid diaphragm to simulate the R.C. slab’s response accurately. The study implements the N2 method, adjusting for seismic demands in an acceleration-displacement format, which leverages the displacement spectrum defined by Supreme Decree 61, a legislative response to the 8.8 Mw Maule earthquake in 2010. The findings reveal that the analyzed structure meets the immediate occupancy performance level with drifts nearing 5‰ in the symmetrical Y direction. This outcome aligns with prior assessments of Chilean R.C. wall buildings. However, in the asymmetric X direction, the structure exhibits a higher degree of structural damage, aligning with a life safety performance level. This differentiation underscores the critical need for nuanced understanding and modeling of structural behavior under seismic loads, contributing to the ongoing refinement of seismic design practices and standards.
Mitigating Blast Hazards: Experimental Evaluation of Anti-Shatter Films and Catcher-Cable Systems on Conventional Windows
Authors: Andrae Matthias , van der Woerd Jan Dirk , Wagner Matthias , Pietzsch Achim , Gebbeken Norbert
Published: March 2024

In light of terrorist attacks and accidents, the need for structural protection against explosive events has increased significantly in recent decades. Conventional unprotected windows pose a particularly high risk of injury to building occupants due to glass fragments and window frames being propelled into the interior and exterior of a building. This article addresses new experimental research on the protection of conventional single casement windows with insulating glass units (double-paned) and window frames made of un-plasticized polyvinyl chloride (uPVC) against blast loads. Entire window systems were tested in ten shock-tube tests using different retrofit-configurations. The retrofitted protective measures include anti-shatter films and catcher-cable systems. Furthermore, the influence of steel profiles inserted in the window frames is investigated. The applied blast loads met the requirements for ER1-certification according to EN 13541:2012 (tested at a reflected peak overpressure of 66.7 kPa and a reflected maximum impulse of 417.7 kPa∙ms). In the test series, various measurement methods were used to capture the velocity of the window fragments, the dynamic cable forces, and the hazard. The data provide valuable information for the design and implementation of catcher-cable systems for existing buildings, which can improve the occupant safety in the event of an explosion.
Green Energy Harvesting and Management Systems in Intelligent Buildings for Cost-Effective Operation
Authors: Dai Qingbin , Qian Jingui , Li Shun , Tao Li
Published: March 2024

Nowadays, the rise of Internet of Things (IoT) devices is driving technological upgrades and transformations in the construction industry, the integration of IoT devices in buildings is crucial for both the buildings themselves and the intelligent cities. However, large-scale IoT devices increase energy consumption and bring higher operating costs to buildings. Therefore, harvesting the ambient cost-effective and clean energy sources is essential for the future development of intelligent buildings. In this work, we investigate the feasibility of integrating a typical triboelectric droplet energy harvester (DEH) into buildings. We demonstrate the energy harvesting capabilities of DEH on different sloped roof surfaces and complex curved building surfaces by simulating rainy weather with various rainfall intensities. The results indicate energy harvesting efficiency increases with larger tilt angles, which guides future smart architectural designs. This work is significant for the future integration of diversified, all-weather green energy collection and management systems, including raindrop energy, wind power generation, and solar energy, which will contribute to energy conservation and cost control in the next generation of smart buildings.
Date Palm Leaflet-Derived Carbon Microspheres Activated Using Phosphoric Acid for Efficient Lead (II) Adsorption
Authors: Alhawtali Saeed , El-Harbawi Mohanad , El Blidi Lahssen , Alrashed Maher M. , Alzobidi Abdulrahman , Yin Chun-Yang
Published: March 2024

The removal of lead metals from wastewater was carried out with carbon microspheres (CMs) prepared from date palm leaflets using a hydrothermal carbonization process (HTC). The prepared CMs were subsequently activated with phosphoric acid using the incipient wetness impregnation method. The prepared sample had a low Brunauer–Emmet–Teller (BET) surface area of 2.21 m2·g−1, which increased substantially to 808 m2·g−1 after the activation process. Various characterization techniques, such as scanning electron microscopy, BET analysis, Fourier transform infrared, and elemental analysis (CHNS), were used to evaluate the morphological structure and physico-chemical properties of the CMs before and after activation. The increase in surface area is an indicator of the activation process, which enhances the absorption properties of the material. The results demonstrated that the activated CMs had a notable adsorption capacity, with a maximum adsorption capacity of 136 mg·g−1 for lead (II) ions. This finding suggests that the activated CMs are highly effective in removing lead pollutants from water. This research underscores the promise of utilizing activated carbon materials extracted from palm leaflets as an eco-friendly method with high potential for water purification, specifically in eliminating heavy metal pollutants, particularly lead (II), contributing to sustainability through biomass reuse.
Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis
Authors: Pan Yujia , Cengiz Roza , Kluiver Joost , Diepstra Arjan , Van den Berg Anke
Published: March 2024

Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed–Sternberg (HRS) cells. This review provides an overview of the currently known miRNA–target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies. The interactions relevant for cHL were extracted by comprehensively reviewing the existing studies on validated miRNA–target gene interactions. The miRNAs with potential critical roles included miR-155-5p, miR-148a-3p, miR-181a-5p, miR-200, miR-23a-3p, miR-125a/b, miR-130a-3p, miR-138, and miR-143-3p, which target, amongst others, PU.1, ETS1, HLA-I, PD-L1, and NF-κB component genes. Overall, we provide a comprehensive perspective on the relevant miRNA–target gene interactions which can also serve as a foundation for future functional studies into the specific roles of the selected miRNAs in cHL pathogenesis.
Multimodal, Technology-Assisted Intervention for the Management of Menopause after Cancer Improves Cancer-Related Quality of Life—Results from the Menopause after Cancer (Mac) Study
Authors: Donohoe Fionán , O’Meara Yvonne , Roberts Aidin , Comerford Louise , Valcheva Ivaila , Kearns Una , Galligan Marie , Higgins Michaela J. , Henry Alasdair L. , Kelly Catherine M. , Walshe Janice M. , Hickey Martha , Brennan Donal J.
Published: March 2024

Background: Vasomotor symptoms (VMSs) associated with menopause represent a significant challenge for many patients after cancer treatment, particularly if conventional menopausal hormone therapy (MHT) is contraindicated. Methods: The Menopause after Cancer (MAC) Study (NCT04766229) was a single-arm phase II trial examining the impact of a composite intervention consisting of (1) the use of non-hormonal pharmacotherapy to manage VMS, (2) digital cognitive behavioral therapy for insomnia (dCBT-I) using Sleepio (Big Health), (3) self-management strategies for VMS delivered via the myPatientSpace mobile application and (4) nomination of an additional support person/partner on quality of life (QoL) in women with moderate-to-severe VMS after cancer. The primary outcome was a change in cancer-specific global QoL assessed by the EORTC QLC C-30 v3 at 6 months. Secondary outcomes included the frequency of VMS, the bother/interference of VMS and insomnia symptoms. Results: In total, 204 women (82% previous breast cancer) with a median age of 49 years (range 28–66) were recruited. A total of 120 women completed the protocol. Global QoL scores increased from 62.2 (95%CI 58.6–65.4) to 70.4 (95%CI 67.1–73.8) at 6 months (p < 0.001) in the intention to treatment (ITT) cohort (n = 204) and from 62 (95%CI 58.6–65.4) to 70.4 (95%CI 67.1–73.8) at 6 months (p < 0.001) in the per-protocol (PP) cohort (n = 120). At least 50% reductions were noticed in the frequency of VMS as well as the degree of bother/interference of VMS at six months. The prevalence of insomnia reduced from 93.1% at the baseline to 45.2% at 6 months (p < 0.001). The Sleep Condition Indicator increased from 8.5 (SEM 0.4) to 17.3 (SEM 0.5) (p < 0.0005) in the ITT cohort and 7.9 (SEM 0.4) to 17.3 (SEM 0.5) (p < 0.001) in the PP cohort. Conclusions: A targeted composite intervention improves the quality of life for cancer patients with frequent and bothersome vasomotor symptoms with additional benefits on frequency, the bother/interference of VMS and insomnia symptoms.
DDX3X and Stress Granules: Emerging Players in Cancer and Drug Resistance
Authors: Zhang Han , Mañán-Mejías Paula M. , Miles Hannah N. , Putnam Andrea A. , MacGillivray Leonard R. , Ricke William A.
Published: March 2024

The DEAD (Asp-Glu-Ala-Asp)-box helicase 3 X-linked (DDX3X) protein participates in many aspects of mRNA metabolism and stress granule (SG) formation. DDX3X has also been associated with signal transduction and cell cycle regulation that are important in maintaining cellular homeostasis. Malfunctions of DDX3X have been implicated in multiple cancers, including brain cancer, leukemia, prostate cancer, and head and neck cancer. Recently, literature has reported SG-associated cancer drug resistance, which correlates with a negative disease prognosis. Based on the connections between DDX3X, SG formation, and cancer pathology, targeting DDX3X may be a promising direction for cancer therapeutics development. In this review, we describe the biological functions of DDX3X in terms of mRNA metabolism, signal transduction, and cell cycle regulation. Furthermore, we summarize the contributions of DDX3X in SG formation and cellular stress adaptation. Finally, we discuss the relationships of DDX3X, SG, and cancer drug resistance, and discuss the current research progress of several DDX3X inhibitors for cancer treatment.
Influence of Oxide Coating Layers on the Stability of Gold Catalysts for Furfural Oxidative Esterification to Methyl Furoate
Authors: Su Juan , Zhan Nannan , Tan Yuan , Min Xiangting , Xiao Yan , Qiao Botao
Published: March 2024

The use of gold nanoparticles (Au NPs) as catalysts has gained widespread attention in various reactions due to their high activity and selectivity under mild reaction conditions. However, one major challenge in utilizing these catalysts is their tendency to aggregate, leading to catalyst deactivation and hindering their amplification and industrial application. To overcome this issue, herein, we used a method by coating the surface of Au NPs with a thin layer of SiO2, which resulted in the formation of a superior catalyst denoted as Au@SiO2/ZA. Characterization studies revealed that the SiO2 layer is coated on the surface of Au NPs and effectively prevents the aggregation and growth of the gold particles during the reaction process, which makes the catalyst display excellent stability in furfural (FF) oxidative esterification to methyl furoate (MF). Moreover, the stabilization strategy is not limited to SiO2 alone. It can also be extended to other oxides such as ZrO2, CeO2, and TiO2. We believe this work will provide a good reference for the design and development of an efficient and stable gold catalyst for the oxidative esterification reaction.
Phosphorylations and Acetylations of Cytochrome c Control Mitochondrial Respiration, Mitochondrial Membrane Potential, Energy, ROS, and Apoptosis
Authors: Morse Paul T. , Arroum Tasnim , Wan Junmei , Pham Lucynda , Vaishnav Asmita , Bell Jamie , Pavelich Lauren , Malek Moh H. , Sanderson Thomas H. , Edwards Brian F.P. , Hüttemann Maik
Published: March 2024

Cytochrome c (Cytc) has both life-sustaining and cellular death-related functions, depending on subcellular localization. Within mitochondria, Cytc acts as a single electron carrier as part of the electron transport chain (ETC). When released into the cytosol after cellular insult, Cytc triggers the assembly of the apoptosome, committing the cell to intrinsic apoptosis. Due to these dual natures, Cytc requires strong regulation by the cell, including post-translational modifications, such as phosphorylation and acetylation. Six phosphorylation sites and three acetylation sites have been detected on Cytc in vivo. Phosphorylations at T28, S47, Y48, T49, T58, and Y97 tend to be present under basal conditions in a tissue-specific manner. In contrast, the acetylations at K8, K39, and K53 tend to be present in specific pathophysiological conditions. All of the phosphorylation sites and two of the three acetylation sites partially inhibit respiration, which we propose serves to maintain an optimal, intermediate mitochondrial membrane potential (ΔΨm) to minimize reactive oxygen species (ROS) production. Cytc phosphorylations are lost during ischemia, which drives ETC hyperactivity and ΔΨm hyperpolarization, resulting in exponential ROS production thus causing reperfusion injury following ischemia. One of the acetylation sites, K39, shows a unique behavior in that it is gained during ischemia, stimulating respiration while blocking apoptosis, demonstrating that skeletal muscle, which is particularly resilient to ischemia-reperfusion injury compared to other organs, possesses a different metabolic strategy to handle ischemic stress. The regulation of Cytc by these post-translational modifications underscores the importance of Cytc for the ETC, ΔΨm, ROS production, apoptosis, and the cell as a whole.
Diversity of Intercellular Communication Modes: A Cancer Biology Perspective
Authors: Ebrahim Thanzeela , Ebrahim Abdul Shukkur , Kandouz Mustapha
Published: March 2024

From the moment a cell is on the path to malignant transformation, its interaction with other cells from the microenvironment becomes altered. The flow of molecular information is at the heart of the cellular and systemic fate in tumors, and various processes participate in conveying key molecular information from or to certain cancer cells. For instance, the loss of tight junction molecules is part of the signal sent to cancer cells so that they are no longer bound to the primary tumors and are thus free to travel and metastasize. Upon the targeting of a single cell by a therapeutic drug, gap junctions are able to communicate death information to by-standing cells. The discovery of the importance of novel modes of cell–cell communication such as different types of extracellular vesicles or tunneling nanotubes is changing the way scientists look at these processes. However, are they all actively involved in different contexts at the same time or are they recruited to fulfill specific tasks? What does the multiplicity of modes mean for the overall progression of the disease? Here, we extend an open invitation to think about the overall significance of these questions, rather than engage in an elusive attempt at a systematic repertory of the mechanisms at play.
Relationships between Motor Skills and Academic Achievement in School-Aged Children and Adolescents: A Systematic Review
Authors: Wang Lijing , Wang Lijuan
Published: March 2024

Purpose: This review systematically summarizes the studies of the relationship between primary-to-secondary school students’ motor skills and academic achievement, and analyzes the relationship between gross and fine motor skills and performance in different subjects. Method: Five electronic databases, Web Of Science, PubMed, PsycINFO, SPORTDiscus, and Academic Search Premier, were searched in March 2023. Semi-quantitative assessment methods were used to analyze the results of the included studies. Results: Seventy-eight articles were included in this systematic review. The semi-quantitative assessment results showed that gross (+, 65.0/62.5%) and fine motor skills (+, 83.3/80%) were positively correlated with overall performance and language performance, with ≥60% of the associations in the same direction. For different subjects, fine motor skills were positively correlated with students’ mathematics (+, 75.0%), reading (+, 72.7%), writing (+, 66.7%), and spelling (+, 60.0%) scores. However, the association between gross motor skills and students’ mathematics achievement (?, 52.8%), reading (?, 53.8%), and spelling (?, 50.0%) is uncertain, with <60% of the associations in the same direction. Conclusions: It is wise to direct our gaze toward the evolution of motor skills among students, especially primary school students. Different motor skill intervention modes should be selected in a targeted manner according to different subject achievements.
High-Efficiency Reconfigurable CMOS RF-to-DC Converter System for Ultra-Low-Power Wireless Sensor Nodes with Efficient MPPT Circuitry
Authors: La Rosa Roberto , Demarchi Danilo , Carrara Sandro , Dehollain Catherine
Published: March 2024

This paper presents a novel CMOS RF-to-DC converter for ultra-low-power wireless sensor nodes powered by RF wireless power transfer. The proposed converter achieves 10% higher power conversion efficiency than a conventional rectifier, with only a 1% increase in power consumption. The system employs a reconfigurable Dickson topology, operates on the unlicensed 868 MHz ISM band, and includes a built-in power-efficient MPPT system architecture. Experimental measurements show a maximum power conversion efficiency of 55% in the power range from −22 dBm to 0 dBm, with a power sensitivity of −22 dBm for a DC output voltage of 2.4 V. The proposed converter offers a promising solution for efficient wireless power transfer and energy harvesting in ultra-low-power wireless sensor nodes.
Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways
Authors: Iacobas Dumitru A. , Allen Haile , Iacobas Sanda
Published: March 2024

Low-salt diet (LSD) is a constant recommendation to hypertensive patients, but the genomic mechanisms through which it improves cardiac pathophysiology are still not fully understood. Our publicly accessible transcriptomic dataset of the left ventricle myocardium of adult male mice subjected to prolonged LSD or normal diet was analyzed from the perspective of the Genomic Fabric Paradigm. We found that LSD shifted the metabolic priorities by increasing the transcription control for fatty acids biosynthesis while decreasing it for steroid hormone biosynthesis. Moreover, LSD remodeled pathways responsible for cardiac muscle contraction (CMC), chronic Chagas (CHA), diabetic (DIA), dilated (DIL), and hypertrophic (HCM) cardiomyopathies, and their interplays with the glycolysis/glucogenesis (GLY), oxidative phosphorylation (OXP), and adrenergic signaling in cardiomyocytes (ASC). For instance, the statistically (p < 0.05) significant coupling between GLY and ASC was reduced by LSD from 13.82% to 2.91% (i.e., −4.75×), and that of ASC with HCM from 10.50% to 2.83% (−3.71×). The substantial up-regulation of the CMC, ASC, and OXP genes, and the significant weakening of the synchronization of the expression of the HCM, CHA, DIA, and DIL genes within their respective fabrics justify the benefits of the LSD recommendation.
Impacts of Climate Change Scenarios on the Corn and Soybean Double-Cropping System in Brazil
Authors: Bigolin Tiago , Talamini Edson
Published: March 2024

Brazil is one of the main producing and exporting countries of corn and soybean and a continental country with climatic diversity that allows the cultivation of these crops in various agricultural systems. Double cropping is a widely adopted system throughout the national territory, where it is possible to cultivate soybeans at the beginning of the growing season, followed by corn in succession, in the same growing season. The present study aims to systematize the scientific knowledge about the impacts of future climate change scenarios on yield and on the double-cropping system of soybean + corn in Brazil. Systematic review procedures were adopted. The soybean yield is projected to increase in all regions of Brazil under all climate scenarios. Corn yields under future climate scenarios are projected to decline, with the subtropical climate region being less affected than the northern regions. The double-cropping systems of soybean + corn tend to present increasing climate risks in tropical climate regions. Climate change scenarios point to a delay in the start of the rainy season that will delay the sowing of soybeans, consequently delaying the sowing of corn in succession, resulting in fewer rainy days to complete its cycle.
Corrosion Behavior of the 2024 Aluminum Alloy in the Atmospheric Environment of the South China Sea Islands
Authors: Zhao Jing , Zhao Tongjun , Zhang Yazhou , Zhang Zhongtian , Chen Zehao , Wang Jinlong , Chen Minghui
Published: March 2024

The 2024 aluminum alloy, a structural material commonly used in aviation aircraft bodies, is susceptible to serious corrosion in marine atmospheric environments. This paper comprehensively studies the corrosion behavior of the 2024 aluminum alloy in the South China Sea atmosphere. Weighing, morphology observation, phase analysis, electrochemical testing, and other methods were used to study the corrosion law and corrosion mechanism of the 2024 aluminum alloy. The main conclusions are as follows: At the initial stage of exposure, pitting corrosion occurred on the surface of the 2024 aluminum alloy. After 3 months of exposure, the self-corrosion current density increased from 0.456 μA·cm−2 to 8.338 μA·cm−2. After 6 months of exposure, the corrosion developed into general corrosion. The main component of the corrosion product was Al2O3·3H2O. The product covered the surface to form a loose corrosion product layer, which had an inhibitory effect on corrosion. The self-corrosion current density was reduced to 2.359 μA·cm−2. After 12 months of exposure, the corrosion product layer fell off and became thinner, and the self-corrosion current density increased to 2.849 μA·cm−2. The corrosion kinetics conformed to the functional equation W = 0.00346t0.73891, indicating that the corrosion products have a certain protective effect on the matrix.