bluuebunny/crossref_metadata_2025 huggingface dataset:
The Picture on the Presentation of Direct Product Group of Two Cyclic Groups
Authors: Yanita Yanita , Rudianto Budi
Published: September 2023

A picture in a group presentation is a geometric configuration with an arrangement of discs and arcs within a boundary disc. The drawing of this picture does not have to follow a particular rule, only using the generator as discs and the relation as arcs. It will form a picture label pattern if drawn with a particular rule. This paper discusses the label pattern of a picture in the presentation of direct product groups. Direct product presentation is used with two cyclic groups,

ℤ

p

and

ℤ

q

where

p
,
q
∈

ℤ

+

and

p
,
q
≥
2

. The method for forming a picture label pattern is to arrange the first generator in the initial arrangement, compile a second generator, and add a number of commutators. Furthermore, the pattern is used to calculate the length of the label on the picture. It is obtained that the picture’s label is

a

q
−
1

b

n

a

b

q
−
n

and the length of the label is

p
+
2
n
−
q

, where

n

is the number of commutator discs.
3D‐Printed Electrocardiogram Dry Electrodes Using Four Commercially Available Polylactic Acid Conductive Filaments
Authors: Aloqalaa Ziyad M.
Published: September 2023

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Therefore, the ability to monitor electrocardiogram (ECG) in the long term could save patients’ lives by allowing early diagnosis and intervention. Dry electrodes are the best option to accomplish this task. 3D printing is one of the popular techniques currently used to construct dry electrodes. This project designs, builds, tests, and compares 3D printed ECG electrodes using four commercially available electrically conductive polylactic acid‐based fuzed deposition modeling filaments. Also, this project uses these printed electrodes to acquire ECG raw signals. Then it compares these signals by calculating their signal‐to‐noise ratio (SNR) and their ability to measure heart rate using the Pan–Tompkins algorithm. Also, the resistance of these printed electrodes is measured. In conclusion, all printed electrodes in this experiment show acceptable efficiency with SNR values equal to or larger than 18.89 dB, and these electrodes prove their ability to measure heart rate using the Pan–Tompkins algorithm. However, according to the results of this experiment, one commercially available brand (Proto‐Pasta) is more favorable to use. Proto‐Pasta has the highest SNR value (20.71 dB), the second lower resistance values (∼ from 600Ωto 2 kΩ), the lowest 60 Hz powerline and low‐frequency noise, the most accurate printed electrodes (the printed electrodes have less shape deformity compared to other brands), and no any noticeable physical malfunction (no knops break from the electrodes during the test process).
Pointwise Hemislant Submanifolds in a Complex Space Form
Authors: Alhouiti Noura
Published: September 2023

In this paper, pointwise hemislant submanifolds were introduced in a Kahler manifold. The integrability conditions for the distributions which are involved in the definition of a pointwise hemislant submanifold were investigated. In addition, the necessary and sufficient conditions were given for a pointwise hemislant submanifold to be a pointwise hemislant product.
The Effect of Medicaid Eligibility on Utilization of Services and Access to Care among Health Center Patients: A Regression Discontinuity Design
Authors: Liang Hailun , Tao Lei , Shi Leiyu
Published: September 2023

The United States’ Affordable Care Act (ACA) aims to improve access to and quality of care for low-income patients. To do so, it expands Medicaid eligibility from individuals under 100% of the federal poverty level (FPL) to include those under 138% of the FPL. Based on the 2014 Health Center Patient Survey (a nationally representative survey sponsored by the Health Resources and Services Administration (HRSA) (n = 4,380)), this study examined the effects of the Medicaid eligibility on having a usual source of care and the utilization of preventive services among health center patients. A regression discontinuity approach was used to identify the causative impact of Medicaid enrollment on low-income and nonelderly health center patients. Our findings suggest that Medicaid enrollment led to a substantial increase in the probability of both undergoing a routine checkup and having had a fecal occult blood test within the past year. These results indicate that changes to Medicaid policy have the potential to affect vulnerable populations. The evidence we provide supports the importance of maintaining the ACA due to its expanded Medicaid funding.
Home-Based Individualized Alpha Transcranial Alternating Current Stimulation Improves Symptoms of Obsessive-Compulsive Disorder: Preliminary Evidence from a Randomized, Sham-Controlled Clinical Trial
Authors: Perera M. Prabhavi N. , Bailey Neil W. , Murphy Oscar W. , Mallawaarachchi Sudaraka , Sullivan Caley , Hill Aron T. , Fitzgerald Paul B.
Published: September 2023

Obsessive-compulsive disorder (OCD) is a debilitating mental health condition that is largely resistant to conventional treatments, such as pharmacotherapy and behavioural interventions. Individualized noninvasive brain stimulation techniques such as transcranial alternating current stimulation (tACS) might be capable of successfully treating OCD through modulation of dysfunctional neural circuitry. A randomized, double-blind, sham-controlled, pilot clinical trial involving 25 OCD patients was conducted to investigate the efficacy of tACS in improving OCD severity. Treatments targeting the medial prefrontal cortex (mPFC) were self-administered at home for 6 weeks with a 3-month follow-up. Within the active group, each treatment was delivered at an individualized peak alpha frequency for 30 minutes, while the sham group received 2 blocks of 2-minute treatments at 25 Hz. The clinical severity of OCD and potential symptom improvements were quantified using serial measurements of the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and a linear mixed model analysis was performed to estimate the time-condition effect. There was a significant time-condition interaction in the YBOCS from baseline to 6 weeks (

p
<
0.0001

), indicating that active alpha-tACS was significantly superior to sham in improving OCD severity. A trend-level effect remained at the 3-month follow-up, suggestive of a sustained level of improvement. Additionally, depressive symptoms also showed a significant improvement from baseline to follow-up. Our findings suggest that a six-week, home-based treatment course of individualized alpha-tACS targeting the mPFC is capable of improving OCD symptoms. Further large-scale clinical trials are required to definitively establish tACS as a therapy for OCD.
Table S2 from Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis
Authors: Dressel Nicole , Natusch Loreen , Munz Clara M. , Costas Ramon Santiago , Morcos Mina N.F. , Loff Anja , Hiller Björn , Haase Christa , Schulze Livia , Müller Patrick , Lesche Mathias , Dahl Andreas , Luksch Hella , Rösen-Wolff Angela , Roers Axel , Behrendt Rayk , Gerbaulet Alexander
Published: September 2023

Oligo nucleotide sequences
Table S4 from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , MacInnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: September 2023

Supplementary Table S4 shows the number of participants filtered out at each QC stage (according to Supplementary Table S2).
Supplementary Figure S2 from Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women
Authors: Choi Jihye , Ha Tae-Woong , Choi Hye-Mi , Lee Han-Byoel , Shin Hee-Chul , Chung Woosung , Han Wonshik
Published: September 2023

The absolute risk of developing breast cancer was estimated using data from 20,434 Korean women. The absolute risk of breast cancer was estimated by PRS38_ASN+PRS190_EB for women in different percentiles and age categories. The dotted lines represent the average risks. (A) Lifetime absolute risk (B) 5-year absolute risk
Supplemental Figure 3 from Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas
Authors: Yu Ming , Carter Kelly T. , Baker Kelsey K. , Redman Mary W. , Wang Ting , Vickers Kathy , Li Christopher I. , Cohen Stacey A. , Krane Mukta , Ose Jennifer , Gigic Biljana , Figueiredo Jane C. , Toriola Adetunji T. , Siegel Erin M. , Shibata David , Schneider Martin , Ulrich Cornelia M. , Dzubinski Lynda A. , Schoen Robert E. , Grady William M.
Published: September 2023

Supplemental Figure 3: EVL methylation levels of normal colon for patients with no history of adenoma or cancer after initial colonoscopy (left group) and for levels patients with an adenoma or colorectal cancer detected after initial (middle group). Patients with no follow-up colonoscopies (right group) were not included in the analyses for Comparison Set 2. %mEVL=percentage of DNA that is methylated at the EVL locus assayed.
Supplementary Table S2 from First-in-Human Study of the Radioligand 68Ga-N188 Targeting Nectin-4 for PET/CT Imaging of Advanced Urothelial Carcinoma
Authors: Duan Xiaojiang , Xia Lei , Zhang Zhuochen , Ren Yanan , Pomper Martin G. , Rowe Steven P. , Li Xuesong , Li Nan , Zhang Ning , Zhu Hua , Yang Zhi , Sheng Xinan , Yang Xing
Published: September 2023

Information of healthy subjects and urothelial carcinoma patients enrolled in PET/CT imaging studies using 68Ga-N188 and 18F-FDG
Study Protocol from KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
Authors: Joensuu Heikki , Wardelmann Eva , Eriksson Mikael , Reichardt Annette , Hall Kirsten Sundby , Schütte Jochen , Cameron Silke , Hohenberger Peter , Sihto Harri , Jost Philipp J. , Lindner Lars H. , Bauer Sebastian , Nilsson Bengt , Kallio Raija , Pesonen Tommi , Reichardt Peter
Published: September 2023

Study protocol
Supplementary Data 1 from Phase I Study of Acalabrutinib Plus Danvatirsen (AZD9150) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma Including Circulating Tumor DNA Biomarker Assessment
Authors: Roschewski Mark , Patel Manish R. , Reagan Patrick M. , Saba Nakhle S. , Collins Graham P. , Arkenau Hendrik-Tobias , de Vos Sven , Nuttall Barrett , Acar Melih , Burke Kathleen , White Rafael D. , Udriste Maria , Sharma Shringi , Dougherty Brian , Stetson Daniel , Jenkins David , Mortlock Andrew , Forcina Alessandra , Munugalavadla Veerendra , Flinn Ian
Published: September 2023

Supplementary Data
Supplementary Table 1: Key exclusion criteria
Supplementary Table 2: Prior systemic therapies
Supplementary Table 3: Subsequent anticancer therapy
Supplementary Table 4: Mutations by response: cell-of-origin and genetic subtyping
Supplementary Table 5: Representativeness of Study Participants
Supplementary Figure 1: Study design
Supplementary Figure 2: Plasma concentration of danvatirsen, acalabrutinib, and ACP-5862 (active metabolite of acalabrutinib) consistent with historical monotherapy data
Supplementary Figure 3: EZB-related mutations by treatment response, number of cycles on treatment, cell-of-origin, and LymphGen cluster
Supplementary Figure 4: STAT3 protein and ASO expression detection by IHC
Supplementary Figure 5: Allele frequency over time for all patients by response
Supplementary Figure 6: Copy number dynamics for all patients with available data by response
Supplementary Figure 7: Peripheral blood analysis of gene expression associated with CD19+ B-cell signaling at baseline (A) and for baseline and longitudinal samples (B), and comparison of baseline gene expression of select B- and T-cell–specific genes in PBMCs in responders and nonresponders (C)
Supplementary Figure 8: Peripheral blood analysis of gene expression associated with interferon-gamma signaling: baseline comparison (A) and baseline and longitudinal samples (B)
Supplementary Figure 9: T-cell, B-cell, and NK-cell (TBNK) flow analysis: immunophenotyping in responders and nonresponders at baseline
Supplementary Figure 10: Longitudinal immunophenotyping/immune cell population data (A) and percentage of CD4+ naïve T-cells among all CD4+ T cells (B) at each visit by treatment response
Supplementary Figure 11: Pretreatment and on-treatment levels of cytokines/chemokines
Supplementary Table S5 from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression
Authors: Kohlmeyer Jordan L. , Lingo Joshua J. , Kaemmer Courtney A. , Scherer Amanda , Warrier Akshaya , Voigt Ellen , Raygoza Garay Juan A. , McGivney Gavin R. , Brockman Qierra R. , Tang Amy , Calizo Ana , Pollard Kai , Zhang Xiaochun , Hirbe Angela C. , Pratilas Christine A. , Leidinger Mariah , Breheny Patrick , Chimenti Michael S. , Sieren Jessica C. , Monga Varun , Tanas Munir R. , Meyerholz David K. , Darbro Benjamin W. , Dodd Rebecca D. , Quelle Dawn E.
Published: September 2023

Supplementary Table S5. Abbreviated list of top kinase inhibitory compounds predicted to be effective against MPNSTs from C-Map analyses of the MPNST transcriptome from NF1 patients.
Supplementary Figure S6 from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression
Authors: Kohlmeyer Jordan L. , Lingo Joshua J. , Kaemmer Courtney A. , Scherer Amanda , Warrier Akshaya , Voigt Ellen , Raygoza Garay Juan A. , McGivney Gavin R. , Brockman Qierra R. , Tang Amy , Calizo Ana , Pollard Kai , Zhang Xiaochun , Hirbe Angela C. , Pratilas Christine A. , Leidinger Mariah , Breheny Patrick , Chimenti Michael S. , Sieren Jessica C. , Monga Varun , Tanas Munir R. , Meyerholz David K. , Darbro Benjamin W. , Dodd Rebecca D. , Quelle Dawn E.
Published: September 2023

Supplementary Figure S6. Analysis of helper (CD4) and pan (CD3) T cells in combination therapysensitive versus combination therapy-resistant MPNSTs
Fig. S4 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Authors: Mohammed Sabira , Thadathil Nidheesh , Ohene-Marfo Phoebe , Tran Albert L. , Van Der Veldt Michael , Georgescu Constantin , Oh Sangphil , Nicklas Evan H. , Wang Dawei , Haritha Nair Hariprasad , Luo Wenyi , Janknecht Ralf , Miller Benjamin F. , Wren Jonathan D. , Freeman Willard M. , Deepa Sathyaseelan S.
Published: September 2023

Fig S4 shows transcript levels of Col1a1, western blots for Desmin, a-SMA and b-tubulin, Transcript levels of TGFb
Supplemental Table 1 from Risk Factors for Early-onset Sporadic Colorectal Cancer in Male Veterans
Authors: Imperiale Thomas F. , Myers Laura J. , Barker Barry C. , Larson Jason , Stump Timothy E. , Daggy Joanne K.
Published: September 2023

Supplemental Table 1: Contains descriptive data for all candidate variables in cases and controls
Supplemental Methods 1 from Risk Factors for Early-onset Sporadic Colorectal Cancer in Male Veterans
Authors: Imperiale Thomas F. , Myers Laura J. , Barker Barry C. , Larson Jason , Stump Timothy E. , Daggy Joanne K.
Published: September 2023

Supplemental Methods 1: Contains details pertaining to data analysis
Supplementary Table S2 from Association and Prediction Utilizing Craniocaudal and Mediolateral Oblique View Digital Mammography and Long-Term Breast Cancer Risk
Authors: Chen Simin , Tamimi Rulla M. , Colditz Graham A. , Jiang Shu
Published: September 2023

Supplementary Table S2: Hazards ratio for association between baseline risk factors and breast cancer risk among postmenopausal women using MLO-VPD only.
Supplementary Table S1 from Association and Prediction Utilizing Craniocaudal and Mediolateral Oblique View Digital Mammography and Long-Term Breast Cancer Risk
Authors: Chen Simin , Tamimi Rulla M. , Colditz Graham A. , Jiang Shu
Published: September 2023

Supplementary Table S1: Hazards ratio for association between baseline risk factors and breast cancer risk among postmenopausal women using CC-VPD only.
Supplementary Figure S3 from Association and Prediction Utilizing Craniocaudal and Mediolateral Oblique View Digital Mammography and Long-Term Breast Cancer Risk
Authors: Chen Simin , Tamimi Rulla M. , Colditz Graham A. , Jiang Shu
Published: September 2023

Supplementary Figure S3: Pearson correlation separated by view and case control status.
Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
Authors: Bercier Pierre , Wang Qian Qian , Zang Ning , Zhang Jie , Yang Chang , Maimaitiyiming Yasen , Abou-Ghali Majdouline , Berthier Caroline , Wu Chengchen , Niwa-Kawakita Michiko , Dirami Thassadite , Geoffroy Marie-Claude , Ferhi Omar , Quentin Samuel , Benhenda Shirine , Ogra Yasumitsu , Gueroui Zoher , Zhou Chun , Naranmandura Hua , de Thé Hugues , Lallemand-Breitenbach Valérie
Published: September 2023

PML nuclear bodies (NB) are disrupted in PML-RARA–driven acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) cures 70% of patients with APL, driving PML-RARA degradation and NB reformation. In non-APL cells, arsenic binding onto PML also amplifies NB formation. Yet, the actual molecular mechanism(s) involved remain(s) elusive. Here, we establish that PML NBs display some features of liquid–liquid phase separation and that ATO induces a gel-like transition. PML B-box-2 structure reveals an alpha helix driving B2 trimerization and positioning a cysteine trio to form an ideal arsenic-binding pocket. Altering either of the latter impedes ATO-driven NB assembly, PML sumoylation, and PML-RARA degradation, mechanistically explaining clinical ATO resistance. This B2 trimer and the C213 trio create an oxidation-sensitive rheostat that controls PML NB assembly dynamics and downstream signaling in both basal state and during stress response. These findings identify the structural basis for arsenic targeting of PML that could pave the way to novel cancer drugs.

Significance:

Arsenic curative effects in APL rely on PML targeting. We report a PML B-box-2 structure that drives trimer assembly, positioning a cysteine trio to form an arsenic-binding pocket, which is disrupted in resistant patients. Identification of this ROS-sensitive triad controlling PML dynamics and functions could yield novel drugs.

See related commentary by Salomoni, p. 2505.

This article is featured in Selected Articles from This Issue, p. 2489
Supplementary Figures from CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer
Authors: Sozio Francesca , Schioppa Tiziana , Laffranchi Mattia , Salvi Valentina , Tamassia Nicola , Bianchetto-Aguilera Francisco M. , Tiberio Laura , Bonecchi Raffaella , Bosisio Daniela , Parmentier Marc , Bottazzi Barbara , Leone Roberto , Russo Eleonora , Bernardini Giovanni , Garofalo Stefano , Limatola Cristina , Gismondi Angela , Sciumè Giuseppe , Mantovani Alberto , Del Prete Annalisa , Sozzani Silvano
Published: September 2023

Supplementary Figures 1-7 with legends
Figure S6 from HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion
Authors: Toyoda Kosuke , Yasunaga Jun-ichirou , Shichijo Takafumi , Arima Yuichiro , Tsujita Kenichi , Tanaka Azusa , Salah Tarig , Zhang Wenyi , Hussein Osama , Sonoda Miyu , Watanabe Miho , Kurita Daisuke , Nakashima Kazutaka , Yamada Kyohei , Miyoshi Hiroaki , Ohshima Koichi , Matsuoka Masao
Published: September 2023

Efficacy of the MCT1/4 inhibitor syrosingopine on ATL cells.
Table S7 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Authors: Chen Lanpeng , Pronk Eline , van Dijk Claire , Bian Yujie , Feyen Jacqueline , van Tienhoven Tim , Yildirim Meltem , Pisterzi Paola , de Jong Madelon M.E. , Bastidas Alejandro , Hoogenboezem Remco M. , Wevers Chiel , Bindels Eric M. , Löwenberg Bob , Cupedo Tom , Sanders Mathijs A. , Raaijmakers Marc H.G.P.
Published: September 2023

Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
Table S2 from Time-Dependent Prognostic Value of Serological and Measurable Residual Disease Assessments after Idecabtagene Vicleucel
Authors: Paiva Bruno , Manrique Irene , Rytlewski Julie , Campbell Timothy , Kazanecki Christian C. , Martin Nathan , Anderson Larry D. , Berdeja Jesús G. , Lonial Sagar , Raje Noopur S. , Lin Yi , Moreau Philippe , San-Miguel Jesús F. , Munshi Nikhil C. , Kaiser Shari M.
Published: September 2023

HR for PFS according to MRD status
Data from Time-Dependent Prognostic Value of Serological and Measurable Residual Disease Assessments after Idecabtagene Vicleucel
Authors: Paiva Bruno , Manrique Irene , Rytlewski Julie , Campbell Timothy , Kazanecki Christian C. , Martin Nathan , Anderson Larry D. , Berdeja Jesús G. , Lonial Sagar , Raje Noopur S. , Lin Yi , Moreau Philippe , San-Miguel Jesús F. , Munshi Nikhil C. , Kaiser Shari M.
Published: September 2023

Abstract
The role of measurable residual disease (MRD) in multiple myeloma patients treated with chimeric antigen receptor (CAR) T cells is uncertain. We analyzed MRD kinetics during the first year after idecabtagene vicleucel (ide-cel) infusion in 125 relapsed/refractory multiple myeloma patients enrolled in KarMMa. At month 1 after ide-cel, there were no differences in progression-free survival (PFS) between patients in less than complete response (CR) versus those in CR; only MRD status was predictive of significantly different PFS at this landmark. In patients with undetectable MRD at 3 months and beyond, PFS was longer in those achieving CR versus −6 logarithmic range and reappearance of normal plasma cells in MRD-negative patients were associated with inferior PFS. This study unveils different prognostic implications of serological and MRD response dynamics after ide-cel and suggests the potential value of studying the reappearance of normal plasma cells as a surrogate of loss of CAR T-cell functionality.
Significance:
This is one of the first studies evaluating the impact of CR and MRD dynamics after CAR T therapy in relapsed/refractory multiple myeloma. These data help interpret the prognostic significance of serological and MRD responses at early and late time points after CAR T-cell infusion.

See related commentary by Landgren and Kazandjian, p. 346.

This article is featured in Selected Articles from This Issue, p. 337
Figure S5 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X. , Xia Shanghua , Zhang Haoyu , Parikh Nehal S. , Ye Qiuping , Veiby O. Petter , Bellovin David I. , Ji Yuhua
Published: September 2023

Phenotypic effects of combining ZL-2201 and Doxorubicin
Figure S1 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X. , Xia Shanghua , Zhang Haoyu , Parikh Nehal S. , Ye Qiuping , Veiby O. Petter , Bellovin David I. , Ji Yuhua
Published: September 2023

Synthesis of ZL-2201
FIGURE 4 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X. , Xia Shanghua , Zhang Haoyu , Parikh Nehal S. , Ye Qiuping , Veiby O. Petter , Bellovin David I. , Ji Yuhua
Published: September 2023

ZL-2201 significantly augments antitumor activity of DSB-inducing agents doxorubicin and IR. A, A549 xenografts established in female Balb/c nude mice (n = 8/group) were treated with vehicle, ZL-2201 (20 mg/kg; twice daily), PLD (2.5 mg/kg; every week) and ZL-2201 + PLD for 28 days. Average tumor volume is graphed. B, Individual tumor volumes for A549 xenografts treated with different doses of ZL-2201 (5, 10, 20 mg/kg twice daily) in combination with PLD. One-way ANOVA analysis of Vehicle versus Combo groups was performed. *, P = 0.035; **, P = 0.0011; ***, P < 0.0001. Kruskal–Wallis test: ZL-2201 versus Combo (P = 0.0403), PLD versus Combo (P = 0.0485). C, Body weight change for treatment arms shown in A. D, FaDu xenografts (n = 8/group) treated with Vehicle, ZL-2201(15 mg/kg; every day), IR (2 Gy), and ZL-2201 + IR for 40 days. Tumors were then allowed to grow without treatment for an additional 44 days. E, Mouse body weight changes for each treatment arm shown in D. QD, every day; QID, twice daily; QW, every week.
FIGURE 1 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X. , Xia Shanghua , Zhang Haoyu , Parikh Nehal S. , Ye Qiuping , Veiby O. Petter , Bellovin David I. , Ji Yuhua
Published: September 2023

Evaluation of ZL-2201 antiproliferative activity in vitro. A, Chemical structure of ZL-2201, a potent and selective DNA-PK inhibitor. B, Concentration-dependent response to ZL-2201 in M059J and M059K glioblastoma cancer cells measured by CTG after 6-day of treatment. The graph represents the average inhibitory (IC50) values (n = 3). C, Concentration-dependent response to ZL-2201 in CRISPR KO of ATM in A549 and FaDu cancer cells measured by CTG after 6 days of treatment. The graph represents the average inhibitory (IC50) values (n = 2–5). D, IC50 responses to ZL-2201 in ATM mutant cell lines (black bars) versus ATM WT A549 cell line (gray bar). Cell growth was measured by CTG after 6 days of treatment. The graph represents the average inhibitory (IC50) values (n = 2–6). NCI-H1703 (E) and A549 (F) cancer cells were treated with bleomycin (10 μmol/L) for 2 hours followed by the addition of increasing concentration of ZL-2201 for 2 hours. Whole-cell lysates were harvested, and concentration-dependent inhibition of DNA-PK protein were analyzed by Simple Western.
Meta-Analysis: Triggering Factors of Atopic Dermatitis in Children
Authors: Eka Sari Luthfiana , Haq Arini , Rakhmawati Yustian
Published: September 2023

Background: Atopic dermatitis is a non-communicable skin disorder characterized by intense itching. It is relapsing, recurring, and can have a negative impact on the quality of life of patients and their family members. Atopic dermatitis occurs most often in early infancy and childhood. Atopic dermatitis can occur if there is dysregulation of IgE resulting in a breakdown of the epidermal barrier. There are several factors that trigger the occurrence of atopic rheumatism in children, which can come from environmental factors or medical history.

Aim: For this reason, this study aims to analyze the similarity of output regarding the magnitude of risk factors for atopic dermatitis in children.

Methods: This study was analyzed using a meta-analysis using PRISMA, where there were 7 of 8654 articles that met the criteria for analysis. Meanwhile, the data presentation was carried out using a forest plot with a random effect statistical model.

Results: The presence of pets, children living in environments that have pets (cats or dogs) are known to increase the risk of atopic dermatitis by 5 times compared to children living in environments that do not have animals. pet. The health history factor seen from exclusive breastfeeding, where babies who are exclusively breastfed are significantly less likely to experience atopic dermatitis by 12.5 times compared to babies who are not exclusively breastfed.

Conclusion: Not  giving exclusive breastfeeding and pets affect atopic dermatitis in children (p<0,05).
Gambaran Klinis dan Histopatologi Keratosis Seboroik
Authors: Mayati Suwoko Wika Umayatul Choiroh , Yuniaswan Anggun , Retnani Diah
Published: September 2023

Keratosis seboroik merupakan tumor jinak epidermal yang paling banyak ditemukan dan sering ditemukan pada orangtua yakni sekitar 20% dari populasi keseluruhan. Faktor penyebab pasti kelainan ini masih belum jelas diketahui. Paparan sinar matahari dikatakan sebagai salah satu penyebab dari keratosis seboroik. Lesi dapat berupa bercak kecokelatan yang datar, sirkumskrip dan tampak kusam, dengan permukaan halus seperti beludru dapat pula berbentuk papul atau plak hiperpimentasi, bulat atau lonjong, sirkumskrip, seperti dilapisi lilin (waxy) dengan permukaan verukosa, atau gambaran menempel “stuck on” pada kulit. Keratosis seboroik dapat berupa lesi yang multipel, soliter, disseminata pada usia lanjut, dermatosis papulosa nigra dan juga berupa tanda Leser-Trelat. Penegakkan diagnosis keratosis seboroik melalui anamnesis, pemeriksaan fisik dan dapat dilanjutkan pemeriksaan histopatologi. Terdapat bermacam-macam gambaran histopatologi dari keratosis seboroik sehingga berdasarkan uraian di atas, tinjauan pustaka ini bertujuan untuk menjelaskan berbagai gambaran klinis dari keratosis seboroik beserta gambaran histopatologinya dan dapat membantu pembaca dalam menentukan jenis keratosis seboroik apabila menemukan kasus tersebut.
The Correlation between Nutritional Status and Clinical Outcome of Liver Sirosis Patients at RSUD Dr. Saiful Anwar Malang
Authors: Supriono Supriono , Dianita Mayasari Ema
Published: September 2023

Introduction: Nutritional status is often associated with mortality and disease morbidity, including liver cirrhosis. Assessment of Tricep Skin Fold (TSF) and mid-arm muscle circumference (MAMC) is an easy parameter of nutritional status.

Objective: This study aims to determine the relationship between nutritional status and clinical outcomes in patients with liver cirrhosis.

Methods: The study used a retrospective cohort observational design with a sample of 57 patients with liver cirrhosis with various etiologies. The data comes from the results of anthropometric measurements of patients in the poly or inpatient ward and interviews regarding the history of the disease and complications experienced during the last month. Data analysis used the Chi-square test with a 95% Confidence Interval (CI), p < 0.05, to analyze the relationship between nutritional status (TSF and MAMC) with clinical outcomes of liver cirrhosis (hematemesis melena, degree of esophageal varices grade Hepatic encephalopathy (HE) and degree of ascites).

Results: Based on the TSF and MAMC values, data on cirrhotic patients who experienced nutritional status with the “low” criteria were 33.3% and 57.89%, respectively. The 'low” TSF value significantly correlates with the HE incidence (p = 0.049) with the RR value of 0.461. The relationship between MAMC and the incidence of ascites was statistically significant (0.004), with an RR value of 0.462.

Conclusion: Nutritional status affects the incidence of HE and ascites in liver cirrhosis patients
O teatro de animação no curso de Artes Cênicas da Universidade Federal da Grande Dourados
Authors: Parente José
Published: September 2023

O objetivo deste texto é refletir sobre as contribuições do teatro de animação no âmbito do curso de Artes Cênicas da Universidade Federal da Grande Dourados (UFGD), instituição pública de ensino superior situada em Dourados, município da região sul do estado de Mato Grosso do Sul. O texto destaca as principais ações de ensino, pesquisa e extensão da área coordenadas pelo autor, que é docente do curso desde o ano de 2010.
Entrevista com Sassá Moretti – As múltiplas facetas do Festival Internacional de Teatro de Animação: 13 anos de persistência
Authors: Moretti Sassá , Rodrigues Éder Sumariva
Published: September 2023

Uma das responsáveis pela realização do Festival Internacional de Teatro de Animação (FITA), Maria de Fátima Souza Moretti, mais conhecida como Sassá Moretti, fala a respeito da trajetória ao longo dos 13 anos de existência do festival. Revisita o passado, projeta o futuro.
O Teatro de Sombras no Brasil, sua história e perspectivas contemporâneas
Authors: Oliveira Fabiana Lazzari de
Published: September 2023

Este artigo traz uma análise histórica das influências europeias no teatro de sombras brasileiro e seu estado da arte atual, bem como perpassa o ensino-aprendizagem e as principais companhias teatrais que pesquisam esta linguagem com suas perspectivas e reverberações nos últimos anos.
Relação entre alterações ósseas detectadas na panorâmica e osteoporose
Authors: Moreira Bruna Akinaga , Aoki Eduardo Massaharu , Munhoz Luciana , Arita Emiko Saito
Published: September 2023

Objetivos: Como o rastreio da baixa densidade mineral óssea (DMO) sistêmica pode ser realizado por meio da radiografia panorâmica (RP), a procura por outros sinais detectáveis na RP que possam aumentar a taxa de pacientes indicados corretamente para o exame de densitometria óssea (DXA) ainda é necessária. Este estudo tem como objetivo correlacionar a baixa densidade DMO com o Índice de Massa Corpórea (IMC) e as alterações visíveis na RP: processo estiloide alongado, índice cortical mandibular (ICM) e número de dentes. Material e métodos: Foram utilizadas RPs de 23 pacientes que possuíam exame de DXA, para cada um, três examinadores com níveis diferentes de expertise (iniciante, experiente e expert) os classificaram de acordo com o ICM; o processo estiloide, como normal ou alongado; o número de dentes; e o IMC. Resultados: Foi observada correlação significante entre o ICM e o DXA apenas para o observador expert (r=-0,47). Para as outras variáveis (processo estiloide alongado, número de dentes e IMC) não houve correlações significantes. A concordância inter examinador foi de 0,50 para o observador expert e iniciante, 0,27 para experiente e expert e de 0,58 entre experiente e iniciante. A correlação intraexaminador foi de 0,77 para o expert, 0,48 para o iniciante e de 0,28 para o observador experiente. Conclusão: O ICM apresentou correlação significante com a baixa densidade mineral óssea, porém não foram encontradas evidências da relação de baixa densidade óssea com outros sinais detectáveis na RP.
Soil nematode communities in riverbanks non-invaded and invaded by Fallopia japonica across diverse environmental conditions
Authors: Čerevková Andrea , Jakubcsiková Michaela , Demková Lenka , Renčo Marek
Published: September 2023

Soil nematode communities are one of the most used bioindicators for assessing soil health and soil conditions. However, they are dependent on the presence of plants, some of which, known as ‘invasive’, affect local biodiversity when established. This study aimed to compare the communities of soil nematodes in riverbanks non-invaded and invaded by Fallopia japonica at three sites characterised by different environmental conditions. Our findings indicated that the ecosystem had a larger impact on the nematode communities than did the environmental variability at the study sites. Soil properties, such as pH, moisture content and organic-carbon content, differed significantly amongst the sites, but the nematode communities remained similar. Organic-carbon content was lower, and soil pH was higher, in the ecosystem with invasive F. japonica. Total nematode abundance, the abundances of fungivores, herbivores, omnivores and predators, and the maturity indices were significantly lower with invasive F. japonica. Fungivorous nematodes are essential for breaking down organic matter and releasing nutrients. Herbivorous nematodes respond to changes in the vegetation, and omnivorous and predatory nematodes contribute to the overall biodiversity and ecological balance in the soil ecosystem, so their lower abundance suggests a disturbance in the soil food web. The lower maturity indices suggested a disturbance or degradation of the soil ecosystem, which could have secondary negative effects on plant growth, nutrient availability and ecosystem resilience. These findings indicate that invasion both decreased the abundance of important soil organisms and disrupted the cycling of nutrients, potentially leading to long-term negative consequences for the invaded ecosystems. Understanding and managing the effects of invasive plants such as F. japonica are crucial for preserving soil health and promoting sustainable ecosystem functioning.
Different Propagation Mechanisms of Deep and Shallow Wintertime Extratropical Cyclones over the North Pacific
Authors: Yao Yuling , Zhang Yang , Hodges Kevin I. , Tamarin-Brodsky Talia
Published: September 2023

Extratropical cyclones (ETCs) are three-dimensional synoptic systems in the middle and high latitudes. Previous studies on ETC propagation have typically focused on cyclones identified at a single level. However, more recent studies have found that ETCs have diverse vertical structures and cyclones with different vertical extents always exhibit distinct characteristics and surface impacts. In this work, we study the movement of wintertime (December–February) extratropical cyclones by classifying North Pacific ETCs into deep cyclones, shallow low-level cyclones, and shallow upper-level cyclones, based on reanalysis data from 1979 to 2019. Applying a Lagrangian perspective, we track the cyclones at different vertical levels to investigate the different characteristics and mechanisms for the propagation of deep and shallow ETCs. A potential vorticity (PV) tendency analysis of cyclone-tracking composites reveals that, for deep cyclones, the diabatic heating at 850 hPa and the horizontal advection by the stationary flow at 500 hPa are the main contributors to the poleward movement. For shallow cyclones, the nonlinear advection terms play a dominant role in their meridional motion, advecting shallow low-level cyclones poleward but shallow upper-level cyclones equatorward. A piecewise PV inversion analysis suggests that the nonlinear advection by winds induced from upper-level PV anomalies is responsible for the different performance of nonlinear advection terms for shallow low-level and upper-level cyclones. These findings further our understanding of the mechanisms and variations of cyclone propagation.

Significance Statement

Extratropical cyclones (ETCs) can be identified at different levels in the troposphere. These mobile low pressure cyclonic storms are the main sources of synoptic variability in the extratropics and often bring severe or even disastrous weather. Previous studies on ETC movement have typically been restricted to cyclones identified at a single level. Our study, by identifying ETCs at multiple levels, classifies cyclones into deep, shallow low-level, and shallow upper-level cyclones. For deep cyclones, their poleward movement is found to be a result of diabatic heating at lower levels and dominated by the stationary circulation at upper levels. For shallow cyclones, nonlinear advection determines whether they propagate poleward or equatorward. These findings further our understanding of the mechanisms of cyclone propagation and imply that the movement of deep and shallow cyclones may undergo different changes with different weather and climate impacts in the future, given the enhanced diabatic heating under global warming, which deserves further investigation.
Unraveling the Formation Mechanism of Exceptionally Strong Marine Heatwaves in the Northeast Pacific in 2020
Authors: Ge Zi-An , Chen Lin , Li Tim , Sun Ming
Published: September 2023

Throughout 2020, a persistent marine heatwave (MHW) event occurred in the northeast (NE) Pacific, which exhibited a record-breaking intensity and long duration. Three peaks of sea surface temperature (SST) anomaly are identified in April, July, and November 2020, respectively, all of which are caused by the surface latent heat flux (LH) term. A Taylor expansion analysis for the LH term reveals that positive LH anomaly (LHA) played the decisive role in increasing the latent heating effect, whereas the mixed layer depth anomaly was not important in the 2020 MHW. The positive LHA was primarily caused by the southerly wind anomalies, which advected more humid air from lower latitudes to the NE Pacific and thus reduced the difference between the saturated specific humidity at sea surface and actual surface specific humidity. This reduced sea–air humidity difference was conducive to less evaporation, leading to positive LHA. Using an atmospheric general circulation model forced by observed SSTs, we find that although the atmospheric circulation anomalies associated with the 2020 MHW can be partly constrained by both tropical Pacific SST and local SST over the North Pacific, the role of internal atmospheric variability in the 2020 MHW’s formation cannot be overlooked. The prediction skill for the 2020 MHW in the North American Multimodel Ensemble models is limited to one month, indicating the challenge of accurately predicting MHW in the NE Pacific. The finding about the contribution of sea–air humidity difference to the LHA provides a new insight into the formation mechanism of MHW.

Significance Statement

An exceptionally strong and persistent marine heatwave occurred in the northeast Pacific throughout 2020, with three peaks in April, July, and November, causing considerable damage to local fisheries and ecosystems. This study found that the evolution of this marine heatwave was due to the less-than-normal release of latent heat at the ocean surface. This was mainly caused by the reduced sea–air humidity difference, which was attributed to the increased near-surface moisture transported by southerly wind anomalies. Our model experiments demonstrated that the associated anomaly fields in the atmosphere partly stemmed from stochastic processes. The state-of-the-art dynamic models can only predict this marine heatwave one month in advance, indicating the necessity of improving prediction skill for marine heatwave’s evolution in current models.
Spread the Word: Secondary Crisis Communication of Unethical Destination Incidents via Social Media
Authors: Ruan Wen-Qi , Zhou Yan , Li Yong-Quan , Su Xin-Wei , Zhang Shu-Ning , Deng Fang
Published: September 2023

The communication of unethical destination incidents (UDIs) through social media can be quite complex. Interestingly, the relationship between information forms of UDIs and users’ online behavior has been grossly ignored, especially in the case of secondary crisis communication (SCC). We investigate the heterogeneous impact of UDIs’ information forms on SCC rooted in the Defleur model of communication. Results from three experimental studies revealed that UDIs in video form elicit higher levels of presence and SCC than those in image-text and text forms. Risk perception and anger are important guiding factors in this process. In brief, the diffusion process of UDIs includes the three stages of reception, transformation, and transmission. The study’s findings suggest a new perspective for understanding destination crisis communication and offer practical implications for alleviating the negative impact of destination crisis.
Unpacking the Plus-Size Travel Movement
Authors: Yang Michelle I-Chieh
Published: September 2023

Efforts to promote inclusivity of marginalized groups in tourism have mainly focused on people with disabilities, seniors, and ethnic minorities. However, other marginalized groups such as plus-size travelers have been neglected. The Plus-Size Travel Movement draws attention to travel restrictions and ostracization from the market due to body size and intersectional identities. This study is the first of its kind to address this phenomenon. It aims to unpack the plus-size travel movement through a netnographic analysis of four major online movement platforms. The analysis reveals how community leaders mobilize with different discourses to politicize travel for plus-sized individuals and empower the community. This research seeks to stimulate further scholarly discussion about expanding theoretical approaches that examine consumer marginalization in tourism consumption beyond its current scope. It also provides recommendations for the industry, including engaging with plus-size travel influencers to establish more inclusive practices and policies and following the movement on social media closely to identify ways to enhance the experience of plus-size travelers.
Inflammatory Markers in Mother’s Own Milk and Infant Stool of Very Low Birthweight Infants
Authors: Hoban Rebecca , Nir Hadar , Somerset Emily , Lewis Jordan , Unger Sharon , O’Connor Deborah L.
Published: September 2023

Background:

Mother’s breastmilk is the gold standard for feeding preterm infants. Preterm delivery may be precipitated by inflammatory maternal states, but little is known about milk cytokine profiles and how they correlate with markers of infant gut inflammation (i.e., stool calprotectin) in this vulnerable population.

Research Aim:

To assess cytokines and inflammatory markers in milk from parents of very preterm infants over time as well as correlations between milk and infant’s stool calprotectin.

Method:

This is a secondary analysis of milk samples collected during OptiMoM, a triple-blind randomized clinical trial of infants born < 1250 g (NCT02137473). Longitudinally collected samples were analyzed for cytokines, choline, and inflammatory markers (C-reactive protein [CRP], IFN-γ, IL-10, IL-1β, IL-1ra, IL-6, IL-8, TNF-α). Infant stools were collected for longitudinal calprotectin analysis. Generalized estimating equations quantified longitudinal profiles of milk markers and stool calprotectin, their associations, and the correlation between free choline and C-reactive protein over follow-up.

Result:

Participants included 92 parents and infants (median weeks of gestation 27.3, median birth weight 845 g, and prevalence of male infants 45%). In all, 212 milk samples and 94 corresponding stool calprotectin levels were collected 1–11 weeks postpartum. C-reactive protein was present in much higher concentrations than other markers, and was highest in Week 1 postpartum. It decreased over time. IL-8 and free choline also changed over time while other markers did not. There was no correlation between any milk markers and stool calprotectin.

Conclusion:

Milk from mothers of very preterm infants has detectable inflammatory markers, some of which change over time. Research is needed to determine if infant outcomes are associated with these markers.
Does knowledge make a difference? Understanding how the lay public and experts assess the credibility of information on novel foods
Authors: Ou Mengxue , Ho Shirley S.
Published: September 2023

Drawing on Metzger’s dual-processing model of credibility assessment, this study examines how individuals with varying topical knowledge (laypersons vs experts) assess the credibility of information on novel foods. Online focus group discussions reveal that both groups share similar motivations for assessing the credibility of information on novel foods (e.g. personal relevance and concerns about the impact of unverified information on others). However, they differ in the barriers they encounter during the assessment of information credibility. Both groups employ analytical (e.g. evaluating content quality) and intuitive methods (e.g. looking at source credibility) to assess the credibility of novel food-related information. However, they differ in the cues used for credibility assessment. Laypersons tend to rely on superficial heuristics (e.g. social endorsement cues or surface features), whereas experts rely more on content features and scientific knowledge to evaluate information credibility. Theoretical and practical implications are discussed.