bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy
Authors: Kaga Hajime , Matsumura Hirotoshi , Suzuki Takehiro , Dohmae Naoshi , Odaka Masafumi , Komatsuda Atsushi , Takahashi Naoto , Wakui Hideki
Published: January 2022

Background: Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed in Japan, was reported to cause a rare form of secondary MN (sMN). Between these MN forms, comparative proteomic analysis of glomerular proteins has not been performed.Methods: We used renal biopsy specimens from 6 patients with PLA2R Ab (+) pMN, 6 patients with PLA2R Ab (‒) pMN, 6 patients with BCL-induced sMN, and 5 control cases (time 0 transplant biopsies). Proteins were extracted from laser-microdissected glomeruli and analyzed using mass spectrometry. The quantification values of protein abundance in each MN group were compared with those in the control group.Results: More than 800 proteins with high confidence were identified. Principal component analysis revealed a different distribution between the pMN and sMN groups. For further analysis, 441 proteins matched with ≥3 peptides were selected. Among the pMN and sMN groups, we compared the profiles of several protein groups based on the structural and functional characteristics, such as immunoglobulins, complements, complement-regulating proteins, podocyte-associated proteins, glomerular basement membrane proteins, and several proteins that are known to be associated with kidney diseases, including MN. In all MN groups, increased levels of immunoglobulins (IgG, IgA, and IgM), complements (C3, C4, and C9), complement factor H-related protein 5, type XVIII collagen, calmodulin, polyubiquitin, and ubiquitin ligase were observed. For some proteins, such as type VII collagen and nestin, the fold-change values were significantly different between the pMN and sMN groups.Conclusions: Between the pMN and BCL-induced sMN groups, we observed common and different alterations in protein levels such as known disease-associated proteins and potential disease marker proteins. Proteomic analysis of glomerular proteins is a useful approach to improve our understanding of the pathogenesis of glomerular diseases, including MN.
An 'Intermetallic' Molecular Nanomagnet with the Lanthanide Coordinated Only by Transition Metals
Authors: Magott Michał , Brzozowska Maria , Baran Stanisław , Vieru Veacheslav , Pinkowicz Dawid
Published: January 2022

Magnetic molecules known as molecular nanomagnets (MNMs; or single molecule magnets SMMs) may be the key to ultra-high density data storage. A single sub-nanometer MNM is capable of storing a single bit of information while being 2-3 orders of magnitude smaller than the magnetic domains in the current HDD technology. The best performing molecular nanomagnets are designed by carefully arranging p-element donor atoms (C, N or O) around the central magnetic ion. This strategy, however, seems to be reaching its limit as the magnetic memory effect disappears above 80 K for this class of compounds. Inspired by the structure of the hardest intermetallic magnet SmCo5, we have synthesized a nanomagnetic molecule where the central lanthanide (Ln) ion ErIII is coordinated solely by three transition metal (TM) ions in a perfectly trigonal planar fashion. The molecule [ErIII(ReICp2)3] (ErRe3) constitutes the first example of a molecular nanomagnet (MNM; or single molecule magnet SMM) with unsupported Ln-TM bonds and paves the way towards molecular intermetallics with strong direct magnetic exchange interactions. Such interactions are believed to be crucial for quenching the quantum tunneling of magnetization which limits the application of Ln-SMMs as sub-nanometer magnetic memory units.
Evaluation of Saving Energy by Using the Power of Plant Composites as a Thermal Insulation; A case study: Effect of a Local Date Palm Fibers
Authors: Hajihosseini Firouzeh , Mahmoudi Jafar
Published: January 2022

This research focuses on assessing the potential use of the power of local palm fiber (Zahedi) as an eco-friendly composite in order to help the sustainable development. Local date palm fibers are separated into individual fibers and washed in water and then heated in an oven at 60 ° C to dry completely in order to investigation of physical properties. The developed composites were characterized in different ratio and compared in terms of physical and morphological properties. Afterwards, the analysis of scanning electron microscopy (SEM) and dispersive energy spectroscopy (EDS) from date palm fibers of Zahedi was carried out to determine the chemical and microstructure composition of the fibers. It was found that carbon and oxygen, are the only compatible and primary compounds in this palm fiber. Analyzing in the longitudinal direction of the fibers, it can be mentioned that the surface of the samples in nanoscale is irregular with many impurities, cells and pores. Also, the Scanning Electron Microscopy analysis of the fiber diameter shows the average range of the diameter is 107–135 µm. Plant-based composites were characterized in seven ratios by combining the date palm fibers with industrial cornstarch as a matrix which creates the insulator composite totally natural. The amount of thickness swelling and water absorption observed in this study was approved and appropriate for a volume ratio of 1:1 in comparison with other studied compounds. The thermal resistance of the three specimens tested by experiment. To evaluate the insulation capability, the specimens were placed at a chamber in a position to act as an obstacle to the thermal transmission. In this case, by increasing the temperature up to 80°c on one side (inside the chamber) and recording the temperature rise on the opposite side, the thermal insulation ability of the specimens was assessed. According to the results of the practical experiments, combining date palm fiber (DPF) with cornstarch resin as a matrix illustrated that the composite material is applicable, safe and useful as a thermal insulation material at a maximum of 80 °c which is appropriate for preventing heat transfer in buildings.
Prognosis of Skin cancer in Hamadan, Iran (2008-2018)
Authors: Khanlarzadeh Elham , Sobhan Mohammad Reza , Nazari Sasan , Basir Hamidreza Ghasemi , Nazari Saman
Published: January 2022

Objective

Skin cancer is the most common cancer in the world. The study was aimed to determine the prognosis of skin cancer in Hamadan, Iran.
Methods

A cross- sectional study was conducted retrospectively at Sina Hospital in Hamadan, Iran. A total of 3276 cases that had been diagnosed with skin cancer from 2008 to 2018 were reviewed. The variables included early symptoms, location involved, metastasis, prognosis and treatments, were recorded in checklist.
Results

The mean age of the patients were 65.30 ± 14.6 years. The highest and lowest number of skin cancers were on the nose and trunk (29.3 and 3.3%). There was also no significant relationship between radiotherapy, invasion and treatment with skin cancer. The most common pathological type of skin cancers was Basal Cell Carcinoma (BCC). The highest relative invasion was related to Melanoma (26.4%) and the lowest relative invasion was related to BCC (2.1%). The prognosis of skin cancer and 5-year survival rate of patients was 90.7%, respectively.
Conclusion

The most common age of the patients with skin cancer is in the seventh decade of life. The prognosis of patients with different types of skin cancers in this study was very good, indicating that it usually improves.
The comparison of standard and tubeless percutaneous nephrolithotomy (PCNL) in children up to 18 years old
Authors: Mousavi-bahar Seyed Habibollah , Amirhasani Shahriar , Kiani Kian , Moradi Abbas
Published: January 2022

Background

The Percutaneous nephrolithotomy (PCNL) is an endourological method applied as the standard or tubeless method for kidney stones treatment.
Material and Methods

In a retrospective study, 88 surgery units involving 75 children up to 18 years old with kidney stones who underwent the surgery for 8 years with one of the two methods of standard or tubeless PCNL were evaluated and compared considering the success rate of operation, hemoglobin, and hematocrit drop, medications, transfusion, duration of surgery and the length of hospital stay.
Results

Among the 88 patients, 47 cases were operated with the standard PCNL and 41 cases by tubeless method. In children whom operated by standard and tubeless PCNL, the complete success rate of operation was 87.2% and 100% (P = 0.006), the need for blood transfusion was 2.1% and 0% (P = 1.00), the need for opioids was 27.7% and 14.6% (P = 0.134), the decrease in hemoglobin was -1.82±0.94 and -1.30±0.98 mg/dl (P = 0.024), the decrease in hematocrit was -5.40±2.66 and -3.52 ± 3.11 mg/dL (P = 0.003), mean surgery duration was 109.30±53.27 and 101.46±31.92 minutes (P = 0.414), the duration of postoperative hospitalization was 3.38±1.76 and 2.46±1.27 days (P = 0.007) and the frequency of fever was 23.4% and 7.3% (P = 0.04), respectively.
Conclusion

The success rate of kidney stone surgery in children with the tubeless PCNL is higher than the standard method, and its complications are lower.
Novel Lipidomes Profile and Clinical Phenotype Identified in Pneumoconiosis Patients
Authors: Chen Xiaoyang , Shi Liyong , Dai Xiaofang , Yan Furong , Lin Yujun , Lin Lianshun , Zhang Yongquan , Zeng Yiming
Published: January 2022

Pneumoconiosis is a group of occupational lung diseases caused by inhalation of particles of coal, asbestos, silica, or similar substances, leading to fibrosis and loss of lung function. It is the most serious and common occupational disease in the world with an increased incidence but poor prognosis. To further investigate the regulatory mechanisms of lipidomic profiles in pneumoconiosis, we measured plasma lipidomic profiles between pneumoconiosis patients and health. Compared with healthy people, the circulating levels of phosphatidylethanolamine (PE) significantly increased while phosphatidylcholines (PC) and lysophosphatidylcholines (lyso PC) decreased in patients with pneumoconiosis. Clinical trans-omics analyses demonstrated that phenomes in pneumoconiosis was closely correlated with multiple lipids. Our data suggested that trans-omic analysis between clinical phenomes and lipidomes might have the potential to uncover the heterogeneity of lipid metabolism of pneumoconiosis patients and to screen out clinically significant phenome-based lipid panels with potential diagnostic application.
Evaluating the Stability of Outang Landslide in the Three Gorges Reservoir Area Considering the Mechanical Behavior With Large Deformation of the Slip Zone
Authors: Yan Junbiao , Zou Zongxing , Mu Rui , Hu Xinli , Zhang Jincheng , Zhang Wen , Su Aijun , Wang Jinge , Luo Tao
Published: January 2022

The large deformation mechanical properties of slip zone soil play an important role in the stability evolution of landslide. The traditional landslide stability evaluation method can only be used to calculate a single stability factor, which cannot dynamically evaluate the landslide stability as it evolves. The large deformation mechanical properties of slip zone soil from Outang landslide in the Three Gorges Reservoir area are investigated by the indoor repeated direct shear test. Based on the damage theory, the shear damage behavior of slip zone soil with large shear displacement is analyzed, and a mechanical model describing the relationship between shear stress and shear displacement in accordance with the mechanical mechanism of landslide is established. Then, the stability of Outang landslide is dynamically evaluated by skillfully combining the mechanical model and the residual thrust method. The results show that the slip zone soil has obvious softening behavior and constant residual strength under the condition of large deformation. The model with clear physical meaning can reflect the large displacement shear mechanical properties of slip zone soil, which is consistent with the test results. The stability factor of Outang landslide gradually decreases and tends to be constant as landslide moves. The mechanical mechanism of the landslide stability evolving with deformation is the strain softening behavior of the slip zone soil, and the mechanical mechanism of the landslide stability evolving with water level is the reduction of effective stress in anti-sliding section under the influence of reservoir water. It is suggested that active measures should be taken in time in the prevention and control of landslide, and the construction of drainage engineering should be paid attention to for large-scale bank landslides.
Prognostic Value and Computer Image Analysis of p53 in Mantle cell Lymphoma
Authors: Gao Li-Min , Zhang Yue-Hua , Xiang Xiao-Yu , Liu Wei-Ping , Zhang Wen-Yan
Published: January 2022

Background: P53 has different prognostic cutoff values in different mantle cell lymphoma (MCL) studies, and p53 immunohistochemistry (IHC) interpretation is still based on semiquantitative estimation, which might be inaccurate. This study aimed to investigate the optimal cutoff value of p53 for predicting prognosis and the possible use of computer image analysis to identify the positive rate of p53 in patients with MCL. Methods: We used QuPath software to determine the p53 positive rate and compared it to the data obtained by manual counting and semiquantitative estimation. Using the Youden index and Kaplan–Meier survival curve analysis, we generated survival curves. The chi-squared (χ2) test was used to compare MCL cell morphology with p53. Spearman rank correlation test and Bland–Altman analysis were used to compare manual counting, computer image analysis and semiquantitative estimation. Results: The optimal cutoff value of p53 for predicting prognosis was 20% in MCL patients. Patients with p53 ≥ 20% had a significantly worse overall survival (OS) than those with p53 < 20% (P < 0.0001). MCL patients with blastoid/pleomorphic variant cell morphology had more p53 ≥ 20% than the classical type (P < 0.0001). There was a strong correlation between computer image analysis and manual counting of p53 from the same areas in MCL tissues (Spearman's rho = 0.966, P < 0.0001). Conclusions: MCL patients with p53 ≥ 20% have a shorter OS and a tendency toward the blastoid/pleomorphic variant. Computer image analysis could determine the actual positive rate of p53 and is a more attractive alternative than semiquantitative estimation in MCL.
A sustentabilidade como política pública: conceitos e óticas da política ambiental nacional
Authors: Cruz Rodrigo Ramos da , Alencar Hugo Marinni Silva , Silva Hildelayne Ferreira da , Cruz Randerson Ramos da
Published: January 2022

O presente estudo tem como objetivo revisar conceitos de suma importância para a construção da política ambiental brasileira. Para isto, são expostos alguns conceitos de sustentabilidade, além de definições e características de políticas públicas. Em seguida, é feito um breve resgate histórico da política ambiental brasileira, principalmente em ações e movimentos que influenciaram a política ambiental nacional. Utilizou-se como metodologia a revisão bibliográfica. O resgate histórico é necessário para se compreender a política ambiental em três momentos: política ambiental corretiva, preventiva e integradora. A pesquisa permite identificar que, apesar do termo desenvolvimento sustentável ser conhecido desde a conferência de Estocolmo, somente nos anos 1990, com políticas integradoras é que o termo ganhou força e notoriedade, tornando-se um grande foco das políticas públicas ambientais.
BARRIERS TO GIRL CHILD EDUCATION: AN EMPIRICAL STUDY AT SECONDARY LEVEL IN KOHIMA DISTRICT OF NAGALAND
Authors:   Ph.D Scholar in Education, Nagaland University, Kohima Campus & Assistant Professor in Education, State College of Teacher Education (SCTE-Govt.of Nagaland), Kohima-797001., Belho Khriezonuo , Venkata Rao B. ,   Assistant Professor, Department of Education, Nagaland University (A Central University), Kohima Campus, Meriema-797004.
Published: January 2022

In realization of the importance of the girl child, concerted efforts were mounted by the Governments at various levels to improve girls participation in education and redress the gender inequalities in education enrolment and retention. Therefore, the study was undertaken to analyze the psychological and institutional barriers that hinders girl child education at secondary level in Kohima district of Nagaland. The research design adopted for this study was descriptive survey research. The self developed tool used for the study was a closed form of questionnaire on barriers to girls schooling at secondary level where the girls have to either tick yes or no. The instrument was validated by ten experts in Faculty of Education and the same was administered to 500 girl students. In Kohima, there are five EBRCs (Educational Block Resource Centres) and from each EBRC, 100 students from secondary level were selected randomly both from private and government schools. The data collected were analyzed and interpreted in the light of the objective of the study by using percentage analysis. The study reveals that most of the girls feel safe, comfortable and secure to go to school. They also said that there is no gender discrimination and they prefer to study in co-educational institution. The study also reveals that most of the schools have the facilities that are necessary for running a school efficiently and effectively. The study concluded that most of the girls in Kohima do not face barriers in getting education. However, there are few girls who have negative attitude towards education and their school which might be due to cultural beliefs and practices, poverty, poor academic performance, etc. which are quite negligible when compare with the barriers faced by girls in some other communities.
A RETROSPECTIVE STUDY ONFUNCTIONAL OUTCOME OF OPERATED INTERTROCHANTERIC FEMUR FRACTURES REDUCEDWITH A POSITIVE BEAK VS NEUTRAL VS NEGATIVE BEAK - AN ARTICLE AND REVIEW OF LITERATURE
Authors: P. Mahajan Neetin , P. Pande Kartik , Talukder Pritam , Sangma Sunny , Chaudhari Kunal
Published: January 2022

Background: Inter-trochanteric fracture is one of the most common fractures in elderly population around the world due to global rise of osteoporosis, which is generally due to a simple slip and fall in the house hold[1]. It is growing to be a disease burden for orthopedics of our era to manage. With its rise Understanding the important factors in management of IT fracture like stability, reduction, role of posterior-medial wall support, intact lateral wall configuration, will help in choosing implant for better outcome ,thus helping to achieve better post operative results[2]. Hence, understanding the role of posteriomedial wall support in IT fracture reduction in terms of positive, neutral(anatomic) or negative beak and its impact on the post operative fracture stability and early ambulation is of great importance. We conducted a retrospective comparative study in our institution to study the outcome of these configuration and its effect post operatively. Methods: A retrospective comparative study was conducted on 60 patients with Intertrochanteric fracture(38 males and 12 females with a mean age of 64.8years) without any associated fractures in elderly population in a time frame between February 2019 to August 2021 using Cephalo-mudullary nailing and Sliding hip screw in our institution. The subject population was graded into 3 groups based on the postero medial cortical wall support in post operative fracture reduction into positive, neutral(anatomic) and negative beak configuration and its effects on post operative fracture stability and early mobilization. Results: In the post operative analysis it was found that the 24 subjects who had positive configuration in the neck shaft angle versus 16 neutral(anatomic) and 10 negative configuration in their neck shaft angle had a superior and better outcome in terms of early ambulation and better long term stability without any statistical differences in terms of age, sex, post traumatic day or any co-morbidities. Conclusion: Thus, we concluded that the fracture reduction with positive reduction achieved a greater stability in terms of early mobilization and better post operative stability and fracture healing than the neutral and negative neck shaft angle. Further it was seen that neutral configuration also had a superior advantage over negative configuration in post operative follow up with a lesser incidence of varus collapse or implant failure.
ORGANOPHOSPHORUS COMPOUNDS CONTAINING 3-(SUBSTITUTED PHENYL)- 2-THIOXOIMIDAZOLIDIN-4-ONE AS POTENT ANTIMICROBIAL AGENTS
Authors:   Department of Chemistry, Agra College, Agra, 282002., Chaturvedi Kalpana
Published: January 2022

A series of biologically active organophosphorus compounds have been synthesized by the reactions of 4-Chlorophenyl dichlorophosphate with 3-(substitutedphenyl)-2-thioxoimidazolidin-4-one. The compounds have been characterized on the basis of elemental analyses and spectral (IR, 1H NMR 31P NMR) data. All the compounds were screened for their antimicrobial activity .They were found to possess significant anti-microbial activity.
ELECTROMAGNETIC RADIATION THERAPY EFFECT ON DIMENSIONAL STABILITY OF DENTURE BASES AND ITS ORAL HEALTH IMPACT ON DAILY PERFORMANCE
Authors:   Removable Prosthodontics Department, Badr University in Cairo, Egypt., M.El Naggar Shady , M. Eissa Sherihan ,   Fixed and Removable Prosthodontics Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt., S.El Gabry Hisham ,   Fixed and Removable Prosthodontics Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt.
Published: January 2022

Background: The demonstration of moderately simple sterilization-disinfection measures in daily practice is very serious to decrease the probabilities of cross-infection as prosthetic appliances have to be sterilized prior to be transferred to the technician and patient. The used disinfection method should be properly selected due to its great effect on the physical and mechanical properties of denture bases. Aim: This research was conducted to study the consequences of chemical and electromagnetic radiation disinfection methods on dimensional stability and oral health impact on daily performance. Also, to evaluate the effect of repeated microwave disinfection under different conditions. Materials and Methods: Group I: Denture disinfection using (1%) sodium hypochlorite for 10 minutes. Group II: Denture disinfection using electromagnetic radiation (650 W for 3 minutes / once per week) and divided into 2 subgroups: Group II-A: Dentures kept dry during microwave disinfection. Group II-B: Dentures kept wet in distilled water during microwave disinfection. Group III: Denture disinfection using electromagnetic radiation (650 W for 3 minutes / twice per week) and divided into 2 subgroups: Group III-A: Dentures kept dry during microwave disinfection. Group III-B: Dentures kept wet in distilled water during microwave disinfection. Dimensional stability and patient satisfaction using (OIDP) questionnaire were evaluated after one- and three-weeks follow-up periods. Results: Comparison between dimensional changes after 1st & 3rd week revealed insignificant difference in dimensional changes regarding Group I (expansion) & GII-A & GII-B (Shrinkage) after 3rd week as P > 0.05. On the other hand, there was a significant difference (shrinkage) in GIII-A & GIII-B after the 3rd week as P<0.05. Oral health impact on daily performance (OIDP) revealed insignificantly decreased after 3rd week in all groups except GIII-B as OIDP significantly decreased. Conclusion: Complete denture disinfection with sodium hypochlorite preparation showed the least dimensional change (Expansion) with higher patient satisfaction, while electromagnetic radiation treatment (microwave) of complete dentures showed higher dimensional change with lower patient satisfaction especially in wet conditions.
MICROSPHERES: A NOVEL DRUG DELIVERYSYSTEM
Authors:   Department of Pharmaceutics, Matoshri College of Pharmacy, Nashik., Patil Nikita , Patil Pooja ,   Department of Pharmaceutics, Matoshri College of Pharmacy, Nashik., Patil Abhishek ,   Department of Pharmaceutics, Matoshri College of Pharmacy, Nashik., N. Bhavasar Shraddha ,   Department of Pharmaceutics, Matoshri College of Pharmacy, Nashik.
Published: January 2022

Microspheres are freeflowing powders that are made up of proteins or synthetic polymers. They are little spherical particles with diameters ranging from a few millimetres to a few millimetres (typically from 1 to 100 micrometer). Microspheres are microparticles that are employed in applications that require a predictable and constant particle surface area.To achieve the desired impact, the drug should be delivered in an ideal amount at the right time to the target tissue with the least degree of adverse effects and maximal therapeutic efficacy. The microspheres drew a lot of attention because of their long-lasting release and ability to target anticancermedications to the tumor.Microspheres will play a key role in innovative medication delivery in the future, particularly in sick cell sorting, diagnostics, gene & genetic materials, and safe, targeted and precise delivery.
Perceived Ease and Usefulness of Work-Based Learning (WBL) and its Practice among Baccalaureate Nurses in Central Uganda
Authors: Ekong Elizabeth Namukombe
Published: January 2022

The continuous update of knowledge and skills among nurses and midwives is a global, regional, and national requirement to meet the change in the disease burden, technology, and treatment modalities. Work-Based Learning (WBL) provides real-life work experiences by enhancing skills, ability to learn throughout one’s career and providing quality care. This article describes baccalaureate nurses’ ease to engage in and practice WBL, perceived usefulness, and the relationships between perceived ease and usefulness to practice. A descriptive cross-sectional survey was carried out at 11 hospitals in central Uganda. An Open Data Kit (ODK) designed, and the pre-tested structured tool was used to collect data from 251 purposively selected baccalaureate nurses. Measurement of ease, usefulness, and practice was guided by four competencies: self-regulation, effective communication, teamwork, and evidence-based practice. Descriptive and logistic analysis using SPSS 20 was performed. More than half of the respondents perceived it as easy to engage in WBL (Mean 1.65; SD 0.48). The Majority perceived WBL as useful to the individual, institution, patient or family, and care delivery (Mean 3.37; SD 0.45). The Majority practiced WBL (Mean 1.99; SD 0.11). Perceived usefulness of WBL to the institution was the statistically significant predictor for practice (B=3.97; p<0.05; 95% CI. 4.40). Baccalaureate nurses’ ease to engage in and practice WBL was at the borderline, but they perceive it useful. Perceived usefulness to institutions may require strong policies and guidelines for WBL to support nurses’ engagement and promote up-to-date knowledge and skills for better service delivery. There is a need to test the model and explore other factors that influence WBL among baccalaureate nurses.
Prevalence, Associated Socio-demographic Variables, and Health Conditions of Overweight and Obesity among Nurses in a Tertiary Health Institution in North-West Nigeria
Authors: E Anyebe, E
Published: January 2022

Obesity and overweight have become a global public health and social issues, with concerns for demographic determinants and health sequelae. The situation among nurses in Nigeria lacks empirical evidence. This study determined the prevalence, socio-demographic, and health correlates of overweight and obesity among nurses in a tertiary health institution in North-west Nigeria using a descriptive cross-sectional survey. A convenient sample of 225 nurses, selected from different units, was recruited for the study. A questionnaire and anthropometric measurements were used to obtain data. Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 24.0. Body mass index (BMI) was used to categorise weight: <18.5 kg/m2, 18.5 – 24.9 kg/m2, 25 – 29.9kg/m2 and 30kg/m2 and above to define underweight, normal, overweight, and obese respectively. Results showed over a third (38.0%) of nurses in this setting are obese; 28.0% are overweight, 32% have normal weight, while a few (2.0%) are underweight. Married females are more obese or overweight; obesity and overweight seem to increase with age and ranks. Obesity and overweight are associated with hypertension, diabetes mellitus, and arthritis in about 25% of nurses. A high prevalence rate of obesity and overweight is thus found, with about two-thirds (66%) of nurses in the study area being either overweight or obese. This is associated with nurses’ age, gender, marital status, and ranks, and some non-communicable diseases. It is recommended that regular health checks, stress management, and other health promotion activities should form the institutional policy for health schemes and self-care for nurses.
“I ONCE LIVED IN THE NORTH OF THE URALS…” URAL PERIOD OF E. A. NIKOLAEVA’S CREATIVITY (E. A. RANOVA’S CREATIVITY)
Authors: Podlubnova Yulia S.
Published: January 2022

The article is devoted to the Ural period of creativity of the poetess E. A. Nikolaeva-Ranova, who joined the avant-garde group of poets which was called “nichevoki” until 1922, but by no means professing the principles of avant-gardism in her work, on the contrary, inheriting mainly V. Ya. Bryusov, A. A. Akhmatova, S. A. Yesenin etc. For the first time the article completely reconstructs the biography of the poetess, collects and analyzes materials related to the Ural period of creativity (1922-1929). We note that E. A. Nikolaeva, who found herself in the Urals in connection with the expulsion of her husband Alexander Ranov (known in literary circles as the poet who was called “nichevoka” — Aetius Ranov) and lived with him in different cities of the region, E. A. Nikolaeva-Ranova is forced to make a creative and life-creating restructuring and begin cooperation with the Soviet press. Poems and poetries of the Ural period, published mainly in Perm newspapers and magazines, inevitably acquired an agitational sound. E. A. Nikolaeva-Ranova ‘s example shows that in the case of a long stay of visiting writers in the Urals, it makes sense to consider not only their contribution to the creation of the image of the region, but also changes in symbolic statuses or writing manners that happened here, as well as cultural mechanisms leading to these changes. On the other hand, it is also significant that the poetess, who compromises with time in her work, somehow preserved elements of an individual style in some texts that were particularly important to her, leading back to the same poetic practices of the Silver Age.
PAST, PRESENT AND FUTURE IN THE EXECUTION DIARY OF ANDREI ARZHILOVSKY: A MOTIVATIONAL ANALYSIS OF THE TEMPORAL BASIS OF THE EGO-DOCUMENT
Authors: Nikulina Nadezhda A.
Published: January 2022

The article proposes the result of understanding the features of the embodiment of the temporal paradigm (past — present — future) in a personal diary using motivational analysis. The object of attention was the evidence, the person who failed to fit his ideas about the world into the ideological matrix of Soviet Russia, which means that the temporal basis of his diary text is specific and even symptomatic for such writing situations. The story of Andrei Stepanovich Arzhilovsky (1885-1937) is an example of the fate of a person who was formed as a person in the pre-revolutionary era, but in the period of post-revolutionary transformations turned out to be among the enemies of the people. In 1920, he was convicted for the first time for participating in the work of the zemstvo council under Kolchak, and in 1929 as a wealthy peasant. During his life at large (after seven years in the camps) — just over a year — he kept a diary, recording everyday observations there, doubts about the new way of life established in the country, worries about raising children, thinking about the movement of time and the fate of mankind, describing his dreams and statements about books which he read and famous people. Important motives of this ego document are “time”, “memory”, “writing (authorship)” and some other motives (“weather”, “food”, “warmth” etc.), illustrating the worldview attitudes of people, who are not always agree with the transformations taking place in Russia. It is the motivational analysis of this ego-document that allows one to come to the study of topical problems of anthropology and literary criticism, where the life story and personal diary of Andrei Stepanovich Arzhilovsky is a unique source for understanding the universal writing strategies characteristic of Russian life at the beginning of the twentieth century and which have not lost their relevance after many decades.
READING ABOUT SIBERIA: N. A. LUKHMANOVA’S PROSE IN A FOREIGN AUDIENCE
Authors: PERSHINA Alyona I. , ERTNER Elena N.
Published: January 2022

The relevance of the work is due to the urgent need in literary science to introduce new texts into the scientific circulation and into the practice of teaching Russian as a foreign language, deepening the understanding of the phenomenon of Siberia. This study is a methodological development of classes on the analysis of a literary text in a foreign audience, which can be used in the study of Russian as a foreign language, an elective course in literary local history.
The didactic material was based on the texts of the Petersburg writer N. A. Lukhmanova, living in 1800-1805 in Tyumen. Lukhmanova recreated the geopoetic image of the land in the essays “Kerzhaki in the Taiga”, “Belokrinitsky Bishop Afanasy”, “In remote places”, united under the general title “Essays from Life in Siberia” (1896).
“Essays from life in Siberia” written by N. А. Lukhmanova, which are the object of this study, are written on the basis of personal experiences by the author of Western Siberia. The position of the “alien”, in which the author and his heroes are in relation to Siberia, is close to the position of foreign students who come to this region. In this regard, the artistic image of Western Siberia becomes a valuable linguodidactic material, and the texts representing this space receive a high linguoculturological potential.
The novelty of the presented research is determined by the appeal to the progressive scientific methodology, interdisciplinary direction — geopoetics, which makes it possible to reveal the peculiarities of the landscape imagery of the space represented in the literary text. In the context of this methodological direction, this research has developed methodological principles and techniques for studying “Siberian” texts in a foreign audience.
DATINI ARCHIVE DOCUMENTS AS A SOURCE FOR STUDYING THE ETHICAL CONCEPTS OF THE PREMODERN BUSINESS MAN
Authors: EVSTIUNIN Vladislav A.
Published: January 2022

The article provides an analysis of documents from the Datini archive, the purpose of which is to determine the prospects for studying the ethical views of a business person of the premodern era on their material.
During the High and Late Middle Ages in Western Europe, there was a “rise of cities” due to the activities of the most mobile and creative social groups of medieval townspeople — merchants, and later entrepreneurs and financiers. Their occupations and way of life contributed to the development of a different type of behavior, new ethical attitudes. One of these business people was Francesco Datini (1335-1410).
The methodological basis of the research was formed by the theory of the ethos of the Polish researcher Maria Ossovskaya, which was perceived by domestic scientists in the post-Soviet period.
The analysis made it possible to establish the linguistic identity of 148265 letters from the archive. Most of them were written in Tuscan “volgare”. This confirmed the prevailing point of view in historiography about the formation of commercial and financial companies in the cities of medieval Tuscany mainly on the basis of family ties. There were also found letters in Latin, Catalan, Provencal and other languages.
Due to the linguistic diversity of sources and the vast geography of their origin, it seemed the most promising to use the methods of “digital history” in further research, which implies the creation of a prosopographic database of Datini’s correspondents and the construction of a GIS on its basis.
The linguistic affiliation of the letters was the main marker of the cultural and national identity of their authors, however, the supranational factor that united these people was their belonging to the ethos of a business man of the premodern era, which is characterized by a combination of irrational religiosity with the emerging rational pragmatics.
Pearls from the First Gulf Cardiac Amyloidosis Summit 2021
Authors: Shehab Abdullah , Todorova Albena , Ahmed Aysha , Gonzalez-Lopez Esther , Knebel Fabian , Alibazoglu Haluk , Sabbour Hani , Romany Ingy , Krsnik Isabel , Al Ali Juwairiah , Al Humood Khaldoon , Fontana Marianna , Al Zidjali Matlooba , Shah Nishant R.
Published: January 2022

These proceedings from the First Gulf Cardiac Amyloidosis Summit held in June 2021 aimed to increase awareness of cardiac
amyloidosis among the wider medical community in the region. Although the clinical presentation of cardiac amyloidosis is highly variable, a
number of ‘red flags’ have been identified to raise suspicion of the disease and prompt further investigation. Accurate diagnosis of cardiac
amyloidosis is challenging and relies on the integration of clinical, imaging and laboratory investigations. Recent imaging techniques, including
bone scintigraphy together with a complete serum and urine workup, allow, in the majority of patients, accurate non-invasive diagnosis without the
need for confirmatory endomyocardial biopsies. Early differential diagnosis between light-chain (AL) amyloidosis and amyloid transthyretin
amyloidosis (ATTR) is critical for timely delivery of appropriate therapy. AL amyloidosis is a medical emergency requiring chemotherapy and
supportive care. Treatment for ATTR-amyloidosis is most effective when administered early, before development of significant symptoms or
cardiac dysfunction. Optimal management of patients involves close collaboration between multidisciplinary specialists, which may include
hematologists, cardiologists, and other subspecialists, ideally at a designated specialty center with interest and expertise in amyloidosis.
Kinase Inhibitors Involved in the Regulation of Autophagy: Molecular Concepts and Clinical Implications
Authors: Al-Huseini Isehaq , Sirasanagandla Srinivasa Rao , Babu Kondaveeti Suresh , Sofin Ramakrishna Gopala Sumesh , Das Srijit
Published: January 2022

All cells and intracellular components are remodeled and recycled in order to replace the old and damaged cells. Autophagy is a process by which damaged, and unwanted cells are degraded in the lysosomes. There are three different types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. Autophagy has an effect on adaptive and innate immunity, suppression of any tumour, and the elimination of various microbial pathogens. The process of autophagy has both positive and negative effects, and this pertains to any specific disease or its stage of progression. Autophagy involves various processes which are controlled by various signaling pathways, such as Jun N-terminal kinase, GSK3, ERK1, Leucine-rich repeat kinase 2, and PTEN-induced putative kinase 1 and parkin RBR E3. Protein kinases are also important for the regulation of autophagy as they regulate the process of autophagy either by activation or inhibition. The present review discusses the kinase catalyzed phosphorylated reactions, the kinase inhibitors, types of protein kinase inhibitors and their binding properties to protein kinase domains, the structures of active and inactive kinases, and the hydrophobic spine structures in active and inactive protein kinase domains. The intervention of autophagy by targeting specific kinases may form the mainstay of treatment of many diseases and lead the road to future drug discovery.
Retracted: Meet the Editorial Board Member
Authors: Vargo-Gogola Tracy
Published: January 2022

Meet the editorial board member page has been retracted at the request of editorial board member of the journal “Current Drug Targets”.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publishers that manuscripts submitted to this journal should not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and while submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers, if and when the article is accepted for publication.
The Role of LncRNA TUG1 in Obesity-related Diseases
Authors: Xue Mengzhen , Xia Fangqi , Wang Yaqi , Zhu Leiqi , Li Yuanyang , Jia Dengke , Gao Yan , Shi Yue , Zhang Changcheng , He Yumin , Liu Chaoqi , Yuan Ding , Yuan Chengfu
Published: January 2022

As the living standards of people are increasingly improved, obesity has become a hotspot
in our daily life. Obesity has been found as a chronic and recurrent disease with serious adverse consequences.
Over the past few years, several articles indicated that long non-coding RNA taurine increased
gene 1 (lncRNA TUG1), a useful RNA, which was indicated to show a relationship to obesity-
related disease occurrence and development. Exosomes are recognized as an emerging research
field that includes substances actively involved in regulating the molecular mechanisms of disease.
This review summarizes the current relevant TUG1 in different molecular pathways of obesityassociated
diseases, the correlation between exosomes and TUG1, or obesity-associated diseases. The
aim is to explore TUG1 as a novel target for obesity, which can deepen the knowledge regarding the
epigenetic regulation pathway. Furthermore, it is expected to focus on diseases associated with obesity
treatment and diagnosis.
Experimental Determination of Cancer Drug Targets with Independent
Mechanisms of Resistance
Authors: Ashton John C. , Bland Abigail R. , Shrestha Nensi , Berry Maddie , Wilson Christabel
Published: January 2022

Mathematical modelling of tumour mutation dynamics has suggested that cancer drug
targets that have different resistance mechanisms should be good candidates for combination treatment.
This is because the development of mutations that cause resistance to all drugs at once
should arise relatively infrequently. However, it is difficult to identify drug targets fulfilling this requirement
for particular cancers. Here we present four experimental criteria that we argue are necessary
(but not sufficient) conditions that drug combinations should meet in order to be considered
for combination drug treatment aimed at delaying or overcoming cancer drug resistance. We
present the results of our own experiments - guided by these criteria - using anaplastic lymphoma
kinase mutated lung cancer cells. Each set of experiments demonstrate results for different drug
combinations. We conclude that the combination of ALK and MEK inhibitors come closest to
meeting all our criteria.
Combined Transarterial Chemoembolization with Microwave Ablation
versus Microwave Alone for Treatment of Medium Sized Hepatocellular
Carcinoma
Authors: El-Agawy Waleed , El-Ganainy Sara Ahmed , Gad Magdy Abd Almawgoud , Abd-Elsalam Sherief , Mostafa Wessam Abd Alltaif , El-Shewi Mohammed El-Sayed
Published: January 2022

Background & Aims:

Hepatocellular carcinoma (HCC) is the fifth most common cancer
and the second leading cause of cancer-related deaths. The only definitive treatment for both HCC
and cirrhosis is liver transplantation, but long wait times in some regions and a relatively fixed
number of donor organs negatively impact access to liver transplantation. The aim of the work was
to evaluate and compare the short outcome of patients with medium-sized HCC who will undergo
percutaneous microwave ablation (MWA) alone and in combination with TACE.

Methods:

This prospective study included 40 patients with medium-sized HCC lesions who were
classified into two groups; Group A that included twenty patients treated by TACE followed by percutaneous
MWA after 2 weeks and group B that included twenty patients treated by 2 sessions of
percutaneous MWA with 2 weeks interval. Full history taking, clinical examination, laboratory investigation,
abdominal ultrasonography and abdominal tri-phasic computed tomography (CT) with
contrast were obtained from the two groups. Laboratory and radiological follow up of the cases
were done at 1 and 3 months after the treatment.

Results:

There was no statistically significant difference in the sociodemographic criteria, laboratory
measurement and clinical criteria between the cases in the two study groups before initiation of
treatment. The response was slightly better in the combined treatment group, but it did not show a
statistically significant difference. The incidence of complications was higher in the MWA group.

Conclusion::

Hepatocellular carcinoma is a common complication of HCV related cirrhosis. Association
of TACE-MWA led to better response rates than MWA with fewer complications.
The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis
Authors: Mahmoud Ayman M. , Sayed Ahmed M. , Ahmed Osama S. , Abdel-Daim Mohamed M. , Hassanein Emad H.M.
Published: January 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial
joints. RA has well-known clinical manifestations and can cause progressive disability and premature
death along with socioeconomic burdens. Interleukin-6 (IL-6) has been implicated in the pathology
of RA where it can stimulate pannus formation, osteoclastogenesis, and oxidative stress. Flavonoids
are plant metabolites with beneficial pharmacological effects, including anti-inflammatory,
antioxidant, antidiabetic, anticancer, etc. Flavonoids are polyphenolic compounds found in a variety
of plants, vegetables, and fruits. Many flavonoids have demonstrated anti-arthritic activity mediated
mainly through the suppression of pro-inflammatory cytokines. This review thoroughly discusses the
accumulated data on the role of flavonoids on IL-6 in RA.
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent
Authors: Gupta Tanya , Kataria Ritu , Sardana Satish
Published: January 2022

Flavonoids are the secondary plant metabolites with diversities of pharmacological activities like antioxidant, anticancer, anti-inflammatory, hepatoprotective, free radical scavenging activity and antiviral activities. Flavonoids have also been proved as a major contributor to the antimicrobial phytochemicals. Being the major substituent of antibiotics today flavonoids has attained high attention as there is increase in persistence of untreatable microbial infections due to microbial resistance. This review demonstrates the screening, isolation of extracts and derivatisation of various flavonoids and their evaluation for antimicrobial potency. Recent advancements of various derivatives of flavonoids having antimicrobial activity has also been discussed in this review. This review helps researchers to get vast knowledge about flavonoids and also give an idea for current scenario of flavonoids and its applications as antimicrobial agent.