bluuebunny/crossref_metadata_2025 huggingface dataset:
Sensitivity analysis and response surface optimization for process- product characteristics of refractance window dried Curcuma longa
Authors: Talukdar Preetisagar , Baruah Kamal Narayan , Uppaluri Ramagopal V.S.
Published: August 2023

This work addresses the sensitivity and optimality of process product characteristics of refractance window dried Curcuma longa. Based on response surface methodology, parameters such as water bath temperature (65–95°C), drying time (75–360 min) and air-velocity (0.5–1 m/s) have been optimized to achieve best combinations of total phenolic content, total flavonoids content, curcumin content, antioxidant activity, moisture content, and colour indices. The best fit model, influence of independent variables on dependent variables and analysis of variance were considered. The optimized conditions for temperature, drying time, and air velocity were found as 95°C, 75 min, and 0.76 m/s respectively. The results indicated novel optimized conditions for refractance window drying of Curcuma longa in terms of antioxidant activity, total phenolic content, total flavonoid content, curcumin concentration, moisture content, and colour indices. The findings affirmed greater sensitivity of water bath temperature and drying time but not air-velocity.
Seasonality of influenza incidences and its influence on meteorological factors and PM10 in Bangkok, Thailand during 2003-2019
Authors: Anupong Suparinthon , Modchang Charin , CHADSUTHI Sudarat
Published: August 2023

This study investigates the seasonality pattern and association between meteorological factors and particulate matter (PM10) concentration, and influenza incidence in Bangkok, Thailand. We analyze monthly averaged temperature, relative humidity, precipitation, PM10 concentrations, and influenza cases collected from 2003 to 2019 using wavelet analysis and a generalized additive model (GAM). The wavelet transforms analysis shows the periodic patterns of influenza with distinct periods of 0.5 years prior to the influenza pandemic in 2009 and 0.5 and 1 year following the pandemic, demonstrating an important shift after the 2009 pandemic. The result also reveals a significant coherence between climate factors, PM10, and influenza incidence. By using the maximum lag time obtained from the wavelet analysis, our GAM model shows the linear relationships between PM10, relative humidity, precipitation, and influenza incidence, whereas temperature exhibits a nonlinear relationship with influenza cases. These findings contribute to a better understanding of the temporal dynamics of influenza seasonality driven by climate factors and PM10 during the past 17 years. This knowledge would be useful for planning clinical resources and supporting public health under the climate situation in Thailand.
Evaluation of satellite remote sensing-based crop evapotranspiration models over a semi-arid irrigated agricultural farm
Authors: Ghosh Tridiv , Chakraborty Debashis , Das Bappa , Sehgal Vinay K , Mukherjee Joydeep , Roy Debasish , Rathore Pooja , Dhakar Rajkumar
Published: August 2023

The measurement of evapotranspiration (ET) is essential in maintaining the energy and water balance in agricultural ecosystems, and it plays a vital role in the hydrological cycle. Precision irrigation water management requires accurate spatiotemporal coverage of crop ET across the farm. Fortunately, with the availability of multi-temporal high-resolution satellite datasets and remote sensing-based surface energy balance (SEB) models, near-real-time estimation of ET is now possible. A recent study evaluated and compared the performance of several SEB models, including the Surface Energy Balance Algorithm for Land (SEBAL), Surface Energy Balance Index (SEBI), Surface Energy Balance System (SEBS), Simplified Surface Energy Balance (SSEB), Simplified-Surface Energy Balance Index (SSEBI), and Two Source Energy Balance (TSEB) models over semi-arid irrigated farms in India. The study used 24 Landsat images captured during the post-monsoon seasons of 2021-22 and 2022-23. The statistical evaluation revealed that SEBAL had the best overall performance (r = 0.91, MBE= -0.48 mm d− 1, MAE = 0.42 mm d− 1 and RMSE = 0.51 mm d− 1), followed by SSEB, TSEB, SSEBI, SEBI, and SEBS, respectively. While SEBAL, SSEB, S-SEBI, and TSEB models performed similarly, SEBI and SEBS consistently underestimated ET over the season. The spatiotemporal map was also used to evaluate the model's performance, and it could accurately differentiate between ET over less water-intensive pulses and water-intensive wheat fields on the farm. Despite discrepancies among the SEB models, SEBAL can still be an operational tool for mapping ET with high accuracy and sufficient variation across pixels, making it an ideal option for incorporating into irrigation scheduling over semi-arid farms.
HybridGCN for Protein Solubility Prediction 1 with Adaptive Weighting of Multiple Features
Authors: Chen Long , Wu Rining , Zhou Feixiang , Zhang Huifeng , Liu Jian K.
Published: August 2023

The solubility of proteins is a key factor in pharmaceutical research and production. To improve production efficiency and reduce experimental costs, there is a need for computational models that can accurately predict solubility from given datasets. Previous studies have used deep learning models and feature engineering techniques to extract features from raw protein sequences for solubility prediction. However, these approaches have not explored the interrelations between features or their relative importance. This study introduces HybridGCN, a novel Hybrid Graph Convolutional Network that improves solubility prediction accuracy by combining various features, including advanced deep-learning features and classic biophysical features. Through an exploration of the interplay between deep-learning features and biophysical features, it was found that certain biophysical features, particularly evolutionary features, complement the features extracted by advanced deep-learning models. To further enhance the model's capacity for feature representation, ESM, a large protein language model, was used to extract a zero-shot learning feature that captures comprehensive and relevant information related to protein functions and structures. Additionally, a novel feature fusion module called Adaptively Feature Re-weighting (AFR) was proposed to integrate multiple features, allowing for the adjustment of feature importance. Ablation experiments and comparisons demonstrate the effectiveness of the HybridGCN approach, achieving state-of-the-art performance on the public eSOL dataset.
Enhancement of Mechanical Performance and Swelling Resistance in Silicone Rubber through Reinforcement with γ-Methacryloxypropyltrimethoxysilane-Modified Halloysite Nanotubes
Authors: Govindan K , Ramabalan S , Vishvanathperumal S
Published: August 2023

The halloysite nanotubes (HNTs) underwent effective surface treatment using γ-methacryloxypropyltrimethoxysilane (γ-MPS), which facilitated interactions with the aluminol and silanol groups present on the edges and surfaces of the nanotubes. The treated HNTs (mHNTs) were utilized to prepare nanocomposites with silicone rubber vulcanizate. The application of γ-MPS modification aimed to enhance interactions between the surfaces and tubules. This enhancement resulted in a higher crosslinking density and improved dispersion of HNTs within the silicone rubber matrix. To assess the influence of mHNT loading on diverse facets of the resultant rubber nanocomposites, a comprehensive analysis was carried out, covering parameters such as cure characteristics, compression set, swelling behavior, abrasion resistance, and mechanical properties, with precise measurements conducted via the oscillating disc rheometer (ODR), solvent immersion technique, DIN abrader, and tensile testing. Overall, the addition of mHNTs significantly enhanced the characteristics and performance of the silicone rubber nanocomposites. This research underscores the effectiveness of mHNTs as reinforcing agents, opening new avenues for enhancing the qualities of silicone rubber-based materials across diverse applications. The incorporation of mHNTs led to improvements in the tensile modulus, strength, and tear strength of the nanocomposites. Additionally, the silicone rubber/mHNTs nanocomposites exhibited enhanced resistance to swelling due to their robust inter-tubular contacts. The results obtained were analyzed in the context of the samples' microstructure, as examined through FESEM analyses.
Outcome in methadone maintenance treatment of immigrants from the former Union of Soviet Socialist Republics
Authors: Ayali Noya , Sason Anat , Adelson Miriam , Peles Einat
Published: August 2023

Immigrants from the former Union of Soviet Socialist Republics (USSR) are more prevalent in Methadone maintenance treatment (MMT) in Israel than their percentage in the general population.
Aims: To compare their characteristics and outcome to that of Israeli-born and other immigrant patients.
Methods: Retention and survival since admission (June/1993 – Dec/2022) until leaving treatment (for retention), or at the end of follow-up were analyzed. Vital data was taken from a national registry. Predictors were estimated using Kaplan-Meier and Cox regression models.
Results: The USSR patients (N=266) compared with other immigrants (N=126) and Israeli-born (N=689) were more educated (≥12y) (p<0.001), admitted to MMT at a younger age (p<0.001), following a shorter duration of opioid usage (p<0.001). More of them ever injected drugs (p<0.001) and ever drank alcohol (p<0.001). One-year retention was comparable (77.2% vs. 75.6% and 72%, p=0.2) as did opioids discontinuation in those who stayed (p=0.2). Former USSR patients had longer cumulative retention of their first admission (p=0.05) with comparable overall retention since first admission, and survival, although the age of death was younger. Specific origin found immigrants from the Russian Federation with the best outcome, and those from Ukraine as having high HIV seropositive and shorter retention.
Conclusions: Despite several characteristics known to associate with poor outcomes, USSR immigrants showed better adherence to MMT, reflected by their longer cumulative retention in their first admission, lower rate of readmissions, and a comparable survival and overall retention in treatment. Intensive medical and psychiatric intervention to prevent young age deceased is recommended.
RETRACTED: Optimization and Performance analysis on PySpark techniques for lungs X-Ray Images
Authors: Agrawal Saroj , University Yogesh Kumar Gupta Banasthali
Published: August 2023

The authors have requested that this preprint be removed from Research Square.
Non-targeted metabolomics and transcriptomics reveal mechanisms of metabolic differences among roots, stems, and leaves of Cudrania tricuspidata caryophyllata
Authors: Ding Zikang , Zhao Meng , Li Xinyue , Wang Xiaomei , Zhang Zhongshan
Published: August 2023

Background
Cudrania tricuspidata is a traditional Chinese medicinal herb with a long history of application, and has a variety of active ingredients and pharmacological effects. In order to expand the source of new drugs, we analysed the metabolomic and transcriptomic profiles of different tissues of Cudrania. The genetic basis for the accumulation of active ingredients was analysed, providing a theoretical basis for high-quality cultivation of Cudrania.
Results
We detected a total of 1254 metabolites from the three tissues of Cudrania roots, stems, and leaves, and all metabolites were annotated and classified into eight categories by the KEGG database: steroids, lipids, antibiotics, vitamins and cofactors, nucleic acids, peptides, carbohydrates, and organic acids. Flavonoid-rich roots and stems of Cudrania were significantly different from the transcripts of leaves. GO and KEGG enrichment analyses revealed that the differential genes were mainly enriched in Photosynthesis - antenna proteins, Zeatin biosynthesis, Flavone and flavonol biosynthesis, Monoterpenoid biosynthesis pathway. The expression of flavonoid and flavonol biosynthesis-related genes was significantly up-regulated in roots and stems. From the perspective of the differences in metabolites among roots, stems and leaves of Cudrania, it can provide a basis for revealing the material basis of the differences in medicinal properties and efficacy of different parts.
Conclusion
These results indicate that Cudrania is a promising medicinal plant and provide important information for the identification of differential metabolites and major metabolic pathways among different parts of Cudrania, as well as a theoretical reference for the effective use of Cudrania resources.
Mucor circinelloides as an entomopathogenic fungus on melon weevil (Acytopeus curvirostris persicus) from Iran
Authors: Sepasi Narges , Jahani Mehdi , Mirzaee MohammadReza , Mohammdpour kazem
Published: August 2023

Melon weevil, Acytopeus curvirostris persicus Thompson (Col.: Curculionidae), is one of the most important pests of melons that is spread in the Middle East countries. Through sampling from different parts of south Khorasan province, in April to October, a species belonging to the genus Mucor was isolated from mycoses adult melon weevil of A. curvirostris persicus. Identification of fungi was performed using morphological and molecular features and pathogenicity test was done to fulfill Koch's postulates. To perform pathogenicity test, two purified isolates of the mentioned fungus with adjusted spore concentration were sprayed as suspension on the larvae and adult melon weevil. Based on results of morphological data and sequencing of ITS region of ribosomal DNA, fungal specimens was identified as Mucor circinelloides. The results on the pathogenicity (50% mortality on melon weevil larvae and 33% on adults, 10 days after inoculation) demonstrated that M. circinelloides can be considered as a potential biocontrol agent against the melon weevil. Field experiments are still required to evaluate the capacity of genus Mucor circinelloides as a safe biological control.
Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma
Authors: Xing Xiaoyu , Zhang Wei , Liu Liya , Han Liping
Published: August 2023

Background
Neuroendocrine neoplasms (NENs) of the female genital tract are rare. This study aims to enhance our clinical understanding of neuroendocrine carcinoma of the ovary.
Methods
A retrospective review was conducted on 12 patients diagnosed with neuroendocrine carcinoma of the ovary, analyzing clinicopathological characteristics, treatment modalities, and survival status.
Results
The median age at diagnosis was 34.5 years (range: 20 to 62 years). Among the 12 cases, 9 were small cell carcinoma of the ovary (SCCO) and 3 were large cell neuroendocrine carcinoma (LCNEC). Five cases were stage I tumors, one case was stage IV, and six cases were stage III. Eleven patients underwent surgery as part of their treatment. All patients received adjuvant chemotherapy. Among the 12 patients, one patient received radiotherapy, and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after chemotherapy. The median progression-free survival was 13 months, and the median overall survival was 19.5 months. Four cases remained disease-free, while eight cases experienced tumor recurrence, including three cases that resulted in death due to disease recurrence.
Conclusion
Neuroendocrine carcinoma of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical outcomes. Surgical resection remains the mainstay of treatment, with some patients benefiting from adjuvant chemoradiation therapy.
WHO Surgical Checklist in Transplant Surgery: Still another tick box exercise? Results from a Closed Loop Audit at a Medium-Sized Transplant Centre
Authors: Caddy Elliott , Clouser Olivia , Cross Harry , Odugoudar Avinash , Devkaran Bhavesh , Kapoor Kunal , Sharma A , Mehra Sanjay , Sharma Hemant
Published: August 2023

Background: There is compelling evidence that effective teamwork can significantly reduce adverse events in medical settings. Our 2014 audit revealed that the adherence to the WHO Surgical Checklist for renal transplant and vascular access procedures was less than optimal.
Objective: The aim of this re-audit was to quantitatively evaluate any changes in practice since the 2014 findings and recommendations.
Methods: Theatre personnel, comprising surgeons, nurses, and anaesthetists, were spontaneously queried regarding patient and staff details both intra-operatively and post-operatively, as outlined in the WHO Checklist. This was done across 54 surgical sessions with the Transplant Team. Importantly, staff were unaware of this impromptu survey, mitigating the potential for the Hawthorne effect.
Results: The Checklist was rigorously adhered to in 100% of the operations (N=54) across all specified phases (Pre-anaesthesia induction - "Check-in"; Pre-skin incision - "Time out"; Prior to patient exiting the theatre - "Sign out"). These results were benchmarked against the 2014 study. While there was a statistically significant improvement in the recall of the patient's ID and the primary surgeon's name, the name of the assisting surgeon was not remembered in 78% of the queries. Moreover, full retention of the anaesthetist's and scrub nurse's IDs was not achieved. Notably, no intraoperative "never events" or near-miss incidents were recorded in either cohort.
Conclusions: While there was complete adherence to reading the checklist in all operations, the retention of specific details by staff was inconsistent. Although there has been noticeable progress in information retention since 2014, there remains a considerable need for enhancement.
Dapagliflozin improved ventricular remodeling and depressive behavior in post-infarction depressed rats through SIRT1/NLRP3 signal
Authors: wang xiukun , Zhou Jining , Zhao Xin , Han Xueyu , Sun Yazhou , Xu Shengnan , Qu Chuan , Liu Xin , Yang Bo
Published: August 2023

Myocardial infarction(MI)is often associated with depression. Studies have shown that Dapaglifozin(DAPA) has a dual protective effect on Cardiac function and depression. This study aimed to determine the protective effect of DAPA in post-myocardial infarction depression༈Post-MI depression༉rats. Male Sprague-Dawley rats were divided into 5 groups: Control, Myocardial infarction, Depression, Post-MI depression, and Post-MI depression + DAPA groups. The effects of DAPA were detected by echocardiography, hemodynamic tests, behavioral tests, Sirius red staining, H&E staining, enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, fluorimetry, and Flow cytometry. We also cultured rat h9c2 cardiomyocytes in vitro to verify the mechanism of action. We found that taking DAPA significantly improved cardiac function and depressive behavior in rats after myocardial infarction. In addition, DAPA could reduce pyroptosis by upregulating of SIRT1 and downregulating of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome. In vitro experiments, we found that a specific SIRT1 inhibitor can significantly reverse pyroptosis in infarcted myocardial cells. This further indicated that the improvement of DAPA in rats with post-myocardial infarction depression is dependent on the SIRT1/NLRP3 pathway.
The Role of Cobalt Ferrites Nanoparticles on Structural and Electrochmical Properties of Mesoporous Silica for Supercapacitor Applications
Authors: Salama Reda. S. , Alshammari Riyadh H. , Nafady Ayman , Soomro Razium Ali , Gouda Mostafa S. , Awad Fathi S.
Published: August 2023

The research focus in energy storage applications has shifted towards mesoporous silica (MCM-41) material due to its distinct surface, chemical, and electronic properties. However, the electrodes made from mesoporous silica in supercapacitors are unable to meet the growing request for high energy density in electronic devices. To address this limitation, researchers have explored modifying the material with metal oxides, heteroatoms, and conductive polymers, which can provide pseudo-capacitance during charging and discharging processes, thereby enhancing energy density. Among the various materials investigated, ferrite materials, particularly cobalt ferrites (COF), have shown promising electrochemical properties. Nevertheless, their low internal conductivity hinders their usage in supercapacitor applications. Consequently, combining ferrites with MCM-41 has been proposed as a means to enhance the electrochemical behavior. In this study, various contents of COF were loaded on MCM-41. Different characterization methods were used to study the physical and surface properties of the as synthesized materials like XRD, FTIR, SEM, TEM, EDX and SEM-mapping. TEM images confirmed that all the as-synthesized composites retained the mesoporous structure, and the particle size of ferrites ranged from 8 to 14 nm. The cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) techniques were employed to investigate the electrochemical characteristics of the composite materials in H2SO4 electrolyte solution (1.0 M) and a potential window ranging from 0.0 to 0.8 V. The results demonstrated that the incorporation of ferrites onto MCM-41 led to an elevation in specific capacitance, with the highest value (746 F.g-1) observed at 35 COF-MCM-41 composite. However, further increasing the content of ferrites resulted in a decrease in specific capacitance. Furthermore, the prepared composites exhibited excellent cycling stability even after 5000 cycles, with MCM-41, COF, and 35 COF-MCM-41 retaining 84.4%, 89.4%, and 94.8% of their initial specific capacitance, respectively. These findings highlight the significant role played by the dispersion of cobalt ferrite nanoparticles in enhancing pseudocapacitance behavior, thus improving the overall electrochemical performance of the composites.
Prognostic indicators for intracranial metastases from pancreatic cancer: a population-based retrospective Surveillance, Epidemiology, and End Results database analysis
Authors: Ladner Liliana , Bhutada Abhishek S. , Adhikari Srijan , Cuoco Joshua A. , Entwistle John J. , Rogers Cara M. , Marvin Eric A.
Published: August 2023

Purpose
The natural history, treatment options, and clinical outcomes of pancreatic metastases to the brain remain largely unknown. Here, we seek to investigate characteristics that influence overall survival (OS) in pancreatic metastases to the brain.
Methods
This is a population-based retrospective study of OS in 508 patients with pancreatic metastases to the brain using the Surveillance, Epidemiology, and End Results database. Univariate and multivariate Cox regression analyses were utilized, and a predictive nomogram was developed.
Results
All patients had a median OS of 2 months. In the univariate analysis, patients older than 65 years had significantly increased OS (p < 0.001). Patients with liver metastases (p < 0.001) and liver and lung metastases (p < 0.001) exhibited significantly reduced OS. Treatment of the primary tumor with chemotherapy only (p < 0.001), radiation only (p = 0.01), radiation and chemotherapy (p < 0.001), and surgery only (p = 0.01) were associated with increased OS. Resection of a distant metastasis site (p = 0.009) and of a brain metastasis (p = 0.03) were associated with increased OS. In the multivariable analysis, factors that remained significant included patient age (p = 0.01), liver metastases (p < 0.001), liver and lung metastases (p < 0.001), treatment with chemotherapy (p < 0.001), treatment with radiation and chemotherapy (p < 0.001), and treatment with surgery and chemotherapy (p < 0.001). The nomogram had a C-index of 0.766, suggesting congruence between the findings on the nomogram and the results in the internal verification.
Conclusions
Median OS is influenced by age, multiorgan metastases and treatment of the primary tumor. These data highlight the life-prolonging role of treatment, yet improved quality of life remains to be elucidated.
Development of 3D-printed PCL/ Baghdadite Nanocomposite Scaffolds for Bone Tissue Engineering Applications
Authors: Emadi Hosein , Baghani Mostafa , Khodaei Mohammad , Baniassadi Majid , Tavangarian Fariborz
Published: August 2023

A significant obstacle in bone tissue engineering is the creation of biodegradable bone replacements with the requisite mechanical and biological capabilities to treat more severe and intricately shaped injuries. Baghdadite has recently indicated that active biological ions such as silicon (Si4+) and zirconium (Zr4+) have been proven to increase bone growth considerably. In this study, we produced 3D-printed PCL-based scaffolds containing different amounts of Baghdadite using the robocasting solvent technique. Notably, PCL with 40 and 60 wt.% Baghdadite scaffolds (PB40 and PB60) promoted a more biomimetic environment for in vitro bone growth as their proper bioactivity and cell viability results were obtained without the addition of osteoinductive components. The printing process produced 3D scaffolds with a compressive strength of 7.94 MPa and elastic modulus of 29.95 MPa in PB40. According to the analytical prediction models in PB40, the elastic modulus was 24.7 and 26.89 MPa. Also, adding 60 wt.% Baghdadite increased the degradation rate to 5.1% in two months, more than six times that of PCL-based scaffolds. Cell proliferation assay demonstrated that the optical density of MG63 cells after 7 days of culture increased from 1.43 ± 0.03 to 1.82 ± 0.20 in PB40 as compared to pure PCL scaffold. Furthermore, bioactivity evaluation, ion release assessment, and morphological observation results further revealed that incorporating Baghdadite into a 3D-printed PCL-based scaffold could improve bone regeneration. Our findings demonstrate that the PCL/Baghdadite composite scaffold may be efficiently manufactured using 3D-printing technology and is extremely promising for bone tissue engineering applications.
A Methodological Architecture for Spatiotemporal Integration of Heterogeneous Environmental Data
Authors: Slaimi Asma , Scriney Michael , Hegarty Susan , Regan Fiona , O’Connor Noel
Published: August 2023

The authors have requested that this preprint be removed from Research Square.
Some Classical and Fractal Splines for Constrained and Shape Preserving Interpolation and Applications in Solving Differential Equations
Authors: Jain Richa , Nallapu Vijender
Published: August 2023

In this paper, we develop constrained and shape preserving classical splines in one and two variables and fractal splines in two variables. First, we obtain a classical rational spline lying above or below the prescribed piecewise line or contained in a prescribed rectangle. Using a blending technique, we construct a classical bivariate rational spline and study its constrained and shape preserving aspects. The proposed constrained and shape preserving splines are exploited for solving {\it{constraint differential equations}}. We construct a bivariate fractal spline [which is the fixed point of the Read-Bajraktarevi\' c (RB) operator] as a perturbation of our classical bivariate rational spline proposed in this paper. Further, we investigate suitable conditions on the shape parameters and scaling factors so that the proposed fractal surface lies above or below the given plane, or within a prescribed cuboid. Also, we study the positivity and monotonicity preserving aspects of the proposed bivariate fractal spline. It is observed that our bivariate fractal spline converges to the original function as the mesh norm goes to zero. The proposed theoretical results are verified through numerical examples.
Mathematics Subject Classification: 46N20 , 28A80 , 26C15 , 41A05 , 41A29 , 65D05
WITHDRAWN: Immune-Based Subgroups Uncover Diverse Tumor Immunogenicity and Implications for Prognosis and Precision Therapy in Acute Myeloid Leukemia
Authors: Chen Tingting , Zhang Juan , Zeng Hui , Zhang Yue , Zhou Hebing
Published: August 2023

Background Although a considerable proportion of acute myeloid leukemia (AML) patients achieve remission through chemotherapy, relapse remains a recurring and significant event leading to treatment failure. This study aims to investigate the immune landscape in AML and its potential implications for prognosis and chemo-/immune-therapy.Methods Integrated analyses based on multiple sequencing datasets of AML were performed. Various algorithms estimated immune infiltration in AML samples. A subgroup prediction model was developed, and comprehensive bioinformatics and machine learning algorithms were applied to compare immune-based subgroups in relation to clinical features, mutational landscapes, immune characterizations, drug sensitivities, and cellular hierarchies at the single-cell level.Results Two immune-based AML subgroups, G1 and G2, were identified. G1 demonstrated higher immune infiltration, a more monocytic phenotype, increased proportions of monocytes/macrophages, and higher FLT3, DNMT3A, and NPM1 mutation frequencies. It was associated with a poorer prognosis, lower proportions of various immune cell types and a lower T cell infiltration score (TIS).
Die strafrechtlichen Grenzen der Meinungsfreiheit : Eine Analyse der Entscheidungsstruktur des Bundesverfassungsgerichts
Authors: Kronier Philipp
Published: August 2023

In großer Regelmäßigkeit beschäftigt das Bundesverfassungsgericht die Kollision zwischen der Meinungsfreiheit und dem Ehrschutz. Nicht zuletzt dieser Umstand hat dazu geführt, dass das Gericht mittlerweile eine ganze Fülle an dogmatischen Strukturen und Abwägungstopoi für diesen Bereich entwickelt hat. Angesichts der fragmentarischen Struktur des Grundgesetzes, wirft dies die Frage auf, welche Überlegungen und Annahmen das Gericht bei diesem Vorgang angeleitet haben. Dieser Frage will der Aufsatz durch eine verfassungs- und grundrechtstheoretische Analyse der Entscheidungsstruktur nachgehen.
The mediating role of engagement in the relationship between equal opportunities and employee performance
Authors: Ateeq Ali
Published: August 2023

This study aimed to explore the relationship between employee engagement, equal opportunities, and employee performance in Bahraini retail businesses. Using a cross-sectional survey, data were collected from 231 employees and analyzed via SPSS and Smart-PLS, uncovering significant results. Out of the 249 participants invited to the survey, 231 responded. All the variables of the study showed different effects, with equal opportunity and employee engagement (EO → EE) considered the strongest hypotheses in this study at the significance level of 0.01 (β = 0.722, = 0.724, SD = 0.070, t = 10.324, p = 0.000), with f2 = 1.087 above 0.15 and less than 0.35, which was considered a high effect size and strongly supported the hypothesis proposed by the researcher. All hypotheses were supported. The R2 values of independent variables were above 38% for the variance of employee performance, which is considered an excellent fit to the data as evidenced by the squared multiple correlation R2 values for the dependent variables. Finally, EO → EE → JP mediating role indirectly affects JP through EO = 24%, which is considered an excellent effect size.The recent study confirmed a strong positive link between equal opportunities and employee performance, with employee engagement acting as a significant mediator. This suggests that promoting equal opportunities can boost performance, especially when coupled with employee involvement. These findings are important for HRM experts and executives, as they indicate that prioritizing fairness and fostering participation can enhance productivity.
Strategic Human Resource Management (SHRM) Concepts and Models for Virtual Organization Management: A Literature Review
Authors: Abalaka Grace Eleojo
Published: August 2023

Virtual groups have been defined to be an assemblage of persons that are physically or administratively separated but work together concurrently and cooperatively on job procedures through correspondences as well as information technology for achieving definite objectives. Managing a virtual remote workgroup is difficult and requires additional competences when compared to traditional management. Many managers are not capable of remote working or trained for such work situations leading to challenges associated with fulfilment of responsibilities. There is a need for managers to acquire fresh skill set. Understanding the unique social aspects and computer mediated technicalities encompassing management of virtual workforces will enhance organisational productivity likewise create an efficient human resource management (HRM) structure that can enhance attainments. This article is an integrative review of literatures aimed at expanding human resources management scope. In-depth investigations of human resource management literatures, research and theories and their application as well as study of applicable models and theoretical frameworks which can be used to comprehend the peculiar nature of virtual organizations was extensively explored. Findings recognized crucial tasks likewise opportunities emanating from contemporary situations that warrant virtual, remote working and suggestions were proffered that managerial staff and human resource executives can utilize for imminent circumstances that might require innovative work techniques for enhanced organizational performance. Pragmatic indications credibly prove that implementing strategic human resource management (SHRM) processes and strategies in virtual organizations adds value to organisational performances with reference to improved efficiency, greater viability, and reduced staff turnover level. Keywords: Strategic Human Resource Management, Virtual Organizations.
Pancreatic Cancer: A Review on Pathophysiology, Naturopathy, Clinical Treatment and Outcomes
Authors: Chakraborty Rituraj , Dutta Anupam , Baruah Bhargab Jyoti , Kumari Rajni , Sarma Priyanku , Sharma Ankita , Goswami Krishangi , Myakala Haritha , Verma Akalesh Kumar
Published: August 2023

The study aimed to comprehend the molecular mechanisms and pathophysiology of pancreatic cancer with an emphasis on the advances in treatment options and the use of natural products as anticancer agents. The study involved a literature survey using PubMed, Web of Science and Google scholar database. The literature search was done using keywords “Pancreatic cancer”, “Chemotherapy”, “Mutations”, and “Natural compounds”. 266 articles were studied of which 201 were taken into consideration based on relevance to the topic. Pancreatic cancer is associated with mutations of CDKN2A (encoding p16), KRAS, TP53 and SMAD4. MAPK, PI3K-AKT, and TGF- β pathway dysfunction also led to pancreatic cancer. Current clinical trial activities in pancreatic cancer target angiogenesis, surface receptors, cell cycle, DNA damage response, etc. Studies have shown that combining surgical resection with adjuvant chemotherapy increases survival rates in patients. New treatment options are on the rise for this cancer type, which is perioperative or neo-adjuvant therapy. Gemcitabine as a single treatment agent in pancreatic cancer has shown promising response with chemotherapy regimens using two combinations- Folfirinox and Gemcitabine/Nab-Paclitaxel giving a better response rate. Numerous natural substances, including curcumin, aloe vera, and taxol, which suppress oxidative stress, angiogenesis, JAK2 STAT3 pathways, and enhanced natural killer cell activity, have been explored as potential treatments for pancreatic cancer. With pancreatic cancer having a poor prognosis, investigations to comprehend its molecular underpinnings and research on natural chemicals could lead to the development of safer treatment alternatives with enhanced survival rates for pancreatic cancer patients.
Exploring the Potential of Nanocarriers for Targeted Delivery of Anti-acne
Agents: A Review
Authors: Dhingra Prabhat , Garg Unnati , Jain Neha , Kaul Shreya , Nagaich Upendra
Published: August 2023

Acne is one of the most prevalent skin conditions among adolescents, which can often continue
to adulthood. It is characterized by the appearance of comedones along with blackheads, whiteheads,
papules, pimples, and pinheads on the neck, face, and back. The most common cause of acne is the bacteria
Propionibacterium acnes, but factors like hormonal imbalance, anxiety, and genetic makeup can often
be responsible. Despite the availability of numerous anti-acne agents, their efficacy is often limited due to
poor skin penetration and adverse effects. Nanocarriers have emerged as a promising approach for the
targeted delivery of anti-acne agents to the skin. This review discusses the potential of nanocarriers, including
vesicular systems, biphasic systems, polymeric systems, fullerenes, and carbon nanoparticles, for
enhanced skin penetration and controlled release of anti-acne agents. Various studies have reported using
nanocarriers to successfully deliver agents such as benzoyl peroxide, salicylic acid, and retinoids, resulting
in improved efficacy and reduced side effects. Using nanocarriers has shown promise for developing
combination therapies targeting multiple aspects of acne pathogenesis. However, further research is needed
to optimize the formulation and assess the safety and efficacy of nanocarrier-based anti-acne therapies.
Stimulatory and Inhibitory Effects of Steroid Hormones and Human
Cytochrome P450 (CYP) 3A Inhibitors on Cortisol 6β-Hydroxylation
Catalyzed by CYP3A Subfamilies
Authors: Niwa Toshiro , Tani Misaki , Suzuki Anna , Murakami Mizuho
Published: August 2023

Objective:

The inhibitory and stimulatory effects of several compounds, including steroid hormones and azole antifungal agents, on cortisol 6β-hydroxylation activity by cyto-chrome P450 (CYP) 3A4, polymorphically expressed CYP3A5, and fetal CYP3A7 were com-pared with those on testosterone 6β-hydroxylation to clarify the catalytic properties of the pre-dominant forms of the human CYP3A subfamily.

Methods:

6β-Hydroxylation activities of cortisol and testosterone by CYP3A4, CYP3A5, and CYP3A7 in the absence or presence of dehydroepiandrosterone (DHEA), α-naphthoflavone (ANF), ketoconazole, itraconazole, and voriconazole were measured using high-performance liquid chromatography.

Results:

Lower concentrations of DHEA and ANF increased cortisol 6β-hydroxylation activities catalyzed by CYP3A4 but not those catalyzed by CYP3A5 and CYP3A7. The inhibition strength of azole antifungal agents against cortisol 6β-hydroxylation catalyzed by all CYP3A subfamilies was similar to that of testosterone 6β-hydroxylation. Although the Michaelis constant (Km) in-creased 2-fold in the presence of 20 μM DHEA compared to that of the control, the maximal velocity (Vmax) values gradually increased with increasing DHEA. For ANF, both Km and Vmax values increased, although the Km value decreased at 2.5 μM concentrations. Ketoconazole and itraconazole competitively inhibited cortisol 6β-hydroxylation mediated by CYP3A4 with simi-lar inhibition constants.

Conclusion:

The inhibitory/stimulatory pattern among CYP3A subfamily members differed be-tween cortisol and testosterone, and CYP3A4 was found to be the most sensitive in terms of in-hibition by azole antifungals among the CYP3A subfamily members investigated.
A bio-inspired reinterpretation of symbiotic human-robot collaboration in assembly processes
Authors: Barravecchia F.
Published: August 2023

Abstract. The emergence of collaborative robotics allowed humans and robots to work closely together to perform manufacturing activities. By combining their distinctive strengths and abilities, humans and robots can support each other in completing complex tasks. The relationship between humans and robots is frequently described in the literature as symbiotic. However, the concept of symbiosis, originally conceived in natural science, is often oversimplified as the mere exchange of mutual benefits. In practice, the term ‘symbiosis’ encompasses a wide range of interactions, ranging from relationships with positive impacts to relationships with negative impacts. Understanding the foundation of Human-Robot Symbiosis is crucial for its management. Two are the primary aims of this paper: (i) reinterpreting the collaborative tasks in assembly processes according to the properties of symbiotic relationships; (ii) proposing a novel approach for evaluating assembly tasks based on the bio-inspired features of symbiotic Human-Robot collaborative systems.
Application of high voltage fragmentation to treat end-of-life wind blades
Authors: Diani M.
Published: August 2023

Abstract. The use of composites is constantly increasing in several sectors, from wind energy to automotive, thanks to their mechanical properties, lightweight, and resistance to corrosion. Despite this, the recycling and reuse of these materials in high-added value applications is not yet performed at the industrial level. In particular, End-of-Life (EoL) products are sent to landfills (if possible), incinerated, or inserted in co-processing in cement plants. This work presents an experimental approach to treat End-of-Life wind blades based on High Voltage Fragmentation (HVF). This technology, based on the creation of electric spark channels, is able to generate localized shock waves at the interface between two different materials. The potential of its application has been shown in the literature, but an experimental campaign is needed to find the optimal parameters to obtain an output material with proper characteristics to feed specific output products, following a demand-driven approach.
The influence of material properties and process parameters on energy consumption in the single-screw extrusion of PVC tubes
Authors: Pieressa A.
Published: August 2023

Abstract. Extrusion is one of the most widely used but energy-intensive processes for shaping polymers. It is thus fundamental to understand the process conditions that enable a cost-efficient operation of the extruders. The energy required by the process is highly affected by system variables and material properties in a complex manner. The aim of this work is thus to investigate the correlation between the process settings, the material properties, and the extrusion energy consumption. An extensive experimental campaign was conducted, testing different flexible PVCs. The power was recorded for both the motor of the extruder and the entire machine during continuous single-screw extrusion for various process conditions. A regression model was developed to correlate the specific energy consumption with the material properties, thus providing a valuable tool for estimating the cost of the final manufactured products.
Mechanical recycling of CFRPs: manufacturing and characterization of recycled laminates
Authors: DE FAZIO D.
Published: August 2023

Abstract. Carbon fibre reinforced plastics (CFRPs) are a very attractive family of materials used in various application fields such as automotive, marine or aeronautic, due to their high specific mechanical properties. However, the large use of CFRPs dramatically increases the amount of waste materials that derives from the end-of-life products and the off-cuts generated during the manufacturing. In this contest, especially when thermosetting matrices are considered, the need to further study the recycling process of CFRPs is an open topic, both in academic and industrial research. Therefore, in this experimental campaign, CFRP materials deriving from the aeronautic field were recycled by using a milling process. The obtained chips were sieved and inspected with a confocal microscope aiming to evaluate the presence of residual matrix on the recovered fibre’s surface. Then the sieved reinforcement was impregnated with new epoxy resin and three-point bending tests were performed to understand the mechanical properties of the recycled composite materials. To produce recycled composites, two manufacturing techniques, i.e. open moulding and compression moulding were considered.
Management of Iatrogenic Ureteral Trauma Post Caesarean Section
Authors: Pamungkas Prilian Akbaril Satryo , Daryanto Besut , Kustono Andri
Published: August 2023

Trauma in the ureter occurs in 1-2.5% of all urogenital trauma, and the most common causes of iatrogenic ureteral trauma come from the Obstetrics Gynecology field (59%). One of the causes of delayed diagnosis of ureteral trauma is the lack of operator awareness. This case report described a 29-year-old woman suspected of ureteral trauma after urine-like fluid was found during a cesarean section operation. After 12 days, a clear-yellowish fluid was obtained from the abdominal drain, so the patient was referred to urologists. The abdominal drain produced fluid approximately 250-300cc/24 hours, clear yellow color. IVP and left RPG inferred left distal ureter laceration AAST grade III. Re-exploration, ureteroneocystostomy using Boari Flap technique, and DJ-Stent insertion were done. On the second day postoperative, the abdominal drain production was < 25cc/24 hours in red color. Ureteral trauma is rare, often unnoticed, and often diagnosed late due to a lack of operator alertness.
The Profile of Osteogenesis Imperfecta in Dr. Moewardi General Hospital Year 2020-2021: A Retrospective Study
Authors: Nefihancoro Udi Heru , Malik Ricat Hinaywan
Published: August 2023

Osteogenesis imperfecta (OI) is a heritable bone dysplasia characterized by bone fragility and long bone deformities. This study aims to report the profile of osteogenesis imperfecta in Dr. Moewardi General Hospital. The patients were searched from the medical record, registered from January 1, 2020, to December 31, 2021, in Dr. Moewardi General Hospital, a tertiary hospital in Surakarta, Indonesia. The data were recorded and described in tables as age, sex, type of OI according to Sillence, clinic, ward admission, signs and symptoms, bisphosphonate therapy and its discipline, as well as the surgical/non-surgical treatment. The quantity of male patients is higher than that of females, OI type IV is the most common, the most common sign/symptoms are fracture and blue sclera, and the most common bone to be fractured is the femur. More than half of patients received bisphosphonate therapy, but only a quarter received it routinely. More than half of patients have performed surgery as the treatment of fractures. Osteogenesis imperfecta patients require an interdisciplinary and tailored treatment that involves both medical and surgical components.
COMPARATIVE STUDY ON URBAN TRANSPORT AND THE ENVIRONMENT (CUTE) FRAMEWORK AS STRATEGY FOR THE REDUCTION OF CARBON DIOXIDE EMISSIONS OF ROAD VEHICLES AT ZAPOTE STREET
Authors: L. Acierto Joanna Marie , H. Quilla Susane Marie , N. Valencia Bobby Joel , L. Cueto Geoffrey , F. Monjardin Cris Edward , Wan Mohamed Wan Mazlina
Published: August 2023

Carbon emissions from vehicles contribute significantly to carbon footprint production, which is one of the primary causes of climate change. In Caloocan City, increasing air pollution is observed despite the drastic decrease in air pollutants in major Metro Manila cities. This study primarily aims to provide strategies to reduce carbon dioxide emissions in Zapote St., Caloocan City, through a Comparative study on Urban Transport and the Environment (CUTE) Framework. The study identified that the hourly average carbon footprint contributed by private and public vehicles along Zapote Street is 686.27 and 243.71 kg CO2e on weekdays and 634.65 and 212.97 kg CO2e on weekends. The exploratory data analysis via Python shows that only the vehicle and fuel types affect the emissions volume. Accordingly, the Unified Vehicular Volume Reduction Program (UVVRP) was ineffective. It only resulted in additional private vehicles and increased congestion, indicating the need for an improved public transport system to encourage Filipinos to shift to public transport. Furthermore, the Traffic Volume Emission Projection (TVEP) model projects a decrease of 87.19 kg CO2e per hour in 2023 and 164.72 kg CO2e per hour by 2052, resulting from the 20% reduction in volume upon the implementation of the "no exemption of motorcycles" in the number coding scheme of Caloocan city.