bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase II study of abemaciclib for patients with retinoblastoma-positive, triple-negative metastatic breast cancer
Authors: Goel Shom , Jovanović Bojana , Chu Xiangying , Hughes Melissa , Erick Timothy K. , Russo Douglas , DiLullo Molly , Wrabel Eileen , Jeselsohn Rinath , Lin Nancy U. , Tayob Nabihah , Mittendorf Elizabeth , Schnitt Stuart , Tolaney Sara M.
Published: February 2025

Background: Cyclin-dependent kinase (CDK) 4/6 inhibitors can significantly extend survival when given in combination with endocrine therapy in hormone receptor-positive metastatic breast cancer patients. However, their activity has been relatively underexplored in patients with metastatic triple-negative breast cancer (mTNBC). Methods: We conducted a single-arm phase II study of abemaciclib monotherapy in patients with retinoblastoma-positive (Rb+) mTNBC. Patients were treated with abemaciclib 200 mg orally twice daily until disease progression, unacceptable toxicity, or withdrawal of consent. The primary endpoint was objective response rate (ORR); secondary endpoints included progression-free survival (PFS), overall survival (OS), clinical benefit rate (CBR), disease control rate (DCR), and safety and tolerability. Results: A total of 27 patients were enrolled before the trial was closed early due to slow accrual. Patients had received a median of 2 lines of systemic therapy in the metastatic setting prior to enrollment. After a median follow-up of 28.5 months, the ORR was 0%, the CBR was 14.8%, and the DCR was 22.2%. The median PFS was 1.94 months (95% confidence interval (CI):1.84-11.47), and the median OS was 8.44 months (95% CI:4.57-15.57). Median PFS and OS did not differ significantly based on AR and PD-L1 status. Pre-treatment gene expression profiling of tumor tissue provided some hypothesis-generating insights into biological features associated with clinical benefit in this study. The most common treatment-related adverse events of grade 2 or higher were diarrhea (40.7%), neutropenia (40.7%), anemia (29.6%), and nausea (29.6%). Conclusions: Abemaciclib monotherapy did not show clinical activity in patients with pretreated Rb+ metastatic TNBC.
Supplementary Table 1 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Antibodies used for this study.
Supplementary Figure 5 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib with KRASG12C inhibitors improves efficacy and drives tumor regression in models of CRC and PDAC
Supplementary Figure 3 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Treatment of an NSCLC model with azenosertib + adagrasib results in biomarker changes in vitro and in vivo.
Figure 6 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib with KRASG12C inhibitors shows efficacy in models of innate and acquired resistance to G12C inhibitors in vivo. A, Mean tumor volume ± SEM of subcutaneous SW1573 xenografts in NOD/SCID mice (n = 9/group). B, Mean tumor volume ± SEM of subcutaneous CR2528 PDX in BALB/c nude mice treated for 24 days (n = 8/group). C, Mean tumor volume ± SEM of subcutaneous NCI-H2030-R xenografts in NOD/SCID mice (n = 9/group). Xenografts were passaged and grown in mice maintained on 100 mg/kg sotorasib until grouping. A–C, P < 0.0001 for all comparisons with vehicle; P < 0.0001 for combinations compared with monotherapies. D, Percent T/C of subcutaneous PDX models implanted into athymic nude [Crl:NU(NCr)-Foxn1nu] mice (n = 3/group). Animals were treated for up to 28 days with the indicated compounds. *, P < 0.05; **, P < 0.001. CRC, colorectal cancer; T/C, treated/control; TV, tumor volume.
Figure 4 from The Selective WEE1 Inhibitor Azenosertib Shows Synergistic Antitumor Activity with KRASG12C Inhibitors in Preclinical Models
Authors: Jameson Nathan M. , Kim Daehwan , Lee Catherine , Skrable Blake , Shea Alexandra , Guo Xiao , Izadi Hooman , Abed Mona , Harismendy Olivier , Ma Jianhui , Kim Doris S. , Lackner Mark R.
Published: February 2025

Combination of azenosertib with KRASG12C inhibitors improves efficacy and drives tumor regression in models of colorectal cancer and PDAC. A, Percent change in tumor volume (ΔTV) of individual SW837 xenografts in NOD/SCID mice on day 21 of treatment (n = 8/group). Azenosertib dosed at 60 mg/kg orally every day. Sotorasib and adagrasib dosed at 30 mg/kg orally every day. B, ΔTV of individual SW1463 xenografts in NCG mice on day 21 of treatment (n = 8/group). Azenosertib dosed at 60 mg/kg orally every day. Sotorasib and adagrasib dosed at 30 mg/kg orally every day. C, ΔTV of individual MIA PaCa-2 xenografts in BALB/c nude mice on day 21 of treatment (n = 8/group). Azenosertib dosed at 80 mg/kg orally every day. Sotorasib and adagrasib dosed at 10 mg/kg orally every day. *, complete regression (3/8). A–C, Values below 0 indicate regression. P < 0.0001 for all comparisons with vehicle; P < 0.0001 for all combinations compared with respective monotherapies except SW1463 adagrasib vs. combo (P = 0.67). NSG, NOD/SCID gamma.
Breast hamartoma in the male sex. Case Report
Authors: Enciso Hurtado Ana Aracely , Pacheco González Carlos Orlando , Morado López Alexandra Nohemí , Macías Rodríguez Michelle Georgina , Muñoz Muñoz Mauricio
Published: February 2025

Introduction: Hamartoma of the breast are benign tumors of glandular tissue, they present a hormonal factor in their development, therefore, they are more common in pregnant and lactating women. Case report: A case of hamartoma is present in a man in the sixth decade of life, managed with conservative mastectomy of the nipple-areola complex. Conclusion: In men it is an unusual entity, with an incidence of <1% of all breast lesions, however, they can cause concern because their behavior is similar to malignant tumors, and normally its diagnosis is only confirmed when the entire resection piece is analyzed.
“Curvularia Lunata-Induced Onychomycosis in an Unlikely Host - A Case report”
Authors: Hallal Marwa , Obeid Grace
Published: February 2025

Introduction: Onychomycosis, a fungal infection of the nail apparatus, presents with various manifestations, including subungual hyperkeratosis, onycholysis and nail plate destruction. Established risk factors include trauma, advanced age, and comorbidities such as diabetes and immunosuppression. Trichophyton rubrum, classified as a dermatophyte, is the primary causative agent, with dermatophytes contributing to 60-70% of cases. Nondermatophyte molds (NDM) account for 30-40% of onychomycosis with Candida species being the most commonly identified, while Curvularia species are rarely encountered. Curvularia lunata, a saprobic dematiaceous mold, is an infrequent human pathogen primarily residing in soil. While human diseases caused by Curvularia are rare, they encompass a spectrum from skin infections to endocarditis.
Case presentation: This case report details a 53-year-old male engineer presenting with left big toenail discoloration, revealing a Curvularia lunata-induced onychomycosis through positive KOH preparation and culture. Given the patient's concurrent use of ticagrelor, oral terbinafine hydrochloride was chosen as a therapeutic option, taking into account potential drug-drug interactions. This approach resulted in complete resolution. The discussion emphasizes distinctions in disease severity among immunocompromised and immunocompetent patients, the potential role of trauma in Curvularia infections, and the importance of comprehensive diagnostic examinations.
Conclusion: This case report provides insight into the challenges of accurate diagnosis, emphasizing the need for routine fungal cultures. Additionally, it discusses the complexities of treatment options, considering factors such as drug interactions and patient-specific conditions, and highlighting the importance of tailored management plans. This case is reported because of the rarity of onychomycosis caused by Curvularia in immunocompetent individuals.
Applying the Kessler Foundation modified Story Memory Technique (KF-mSMT ®) to Improve New Learning in Aging Populations
Authors: Chiaravalloti Nancy D. , Weber Erica , Costa Silvana L. , Lengenfelder Jean , Maloku Diana , Moore Nancy B. , DeLuca John
Published: February 2025

Introduction: The current study examines the efficacy of the 10-session Kessler Foundation modified Story Memory Technique (KF-mSMT®) to improve new learning in older adults.
Methods. This double-blind, placebo-controlled randomized clinical trial included twenty-eight individuals over age 65 randomized to the treatment group (n=17) or placebo control group (n=13). Participants completed a baseline neuropsychological assessment, including questionnaires assessing everyday memory, and a repeat assessment immediately post-treatment. The primary outcome measure was the total learning score from the California Verbal Learning Test II (CVLT II) and the secondary outcome measure was total score from the Memory Functioning Questionnaire.
Results: A significant effect of the KF-mSMT® was noted on the CVLT-II total learning score in the treatment group, demonstrating a large effect size. Post-hoc analysis examining benefit from the KF-mSMT in the healthy aging group as compared with the MCI group showed a trend toward significance (p=.069), with a large effect size. With benefit defined as a 10% or greater improvement on the CVLT total learning, 65% of patients in the treatment group showed improvement from baseline to immediate follow-up, compared with 31% of the control group (p=.06). Significant treatment effects were also noted on a self-report measure of memory in daily life, the Memory Functioning Questionnaire. Post-treatment changes in depression or anxiety from before to after treatment were not significant between the groups.
Conclusion: The current study presents preliminary evidence in support of the KF-mSMT® for improving learning and memory abilities in older populations of those aging normally and those meeting criteria for MCI.
The Pharmacology of Cannabinoids in Chronic Pain
Authors: Cortez-Resendiz Alonso , Leiter Timothy J. , Riela Steven M. , Graziane Nicholas M. , Raup-Konsavage Wesley M. , Vrana Kent E.
Published: February 2025

Objective:

Our objective is to provide an overview of the currently available scientific and clinical data supporting the use Cannabis and Cannabis-derived products for the treatment of chronic pain disorders. We also provide information for researchers, clinicians and patients to be better informed and understand the approach behind the recommendation of Cannabis as a potential adjuvant in the treatment/control of chronic pain.

Background:

Cannabis and its bioactive compounds have sparked interest in the field of pain treatment in spite of its controversial history and status as a controlled substance in many countries. With the increase in chronic pain, physicians and patients have started to look at alternative ways to treat pain aside from traditional treatments. One alternative is the use of cannabis to reduce/treat chronic pain disorders based on anecdotal accounts and the function of its phytocannabinoids. The two main cannabinoids in cannabis, THC and CBD, act on CB1 and CB2 receptors (in addition to several additional receptors). It is through these pleiotropic receptor interactions that these compounds elicit their biological function including the reduction of chronic pain. In this narrative review, we included the most recent evidence supporting the use of cannabis in the treatment of chronic pain disorders including chronic neuropathic pain, cancer-induced neuropathic pain, chronic musculoskeletal pain, and chronic headaches and migraines.

Summary:

Evidence suggests that cannabis and cannabinoids have an analgesic effect that arises from a combination of compounds and various receptor systems. These effects may be maximized with the use of a combination of cannabinoids. At the same time, the combination of cannabinoids helps to minimize the undesirable side effects of some cannabinoids such as the psychoactivity of THC. With these findings, further research is necessary to assess the analgesic properties of other cannabinoids like CBC and CBG, and their contributions to the reduction of pain.
Alopecia with male-pattern androgenetic alopecia linked to an adrenal tumor: a case
report
Authors: Figueroa Hernández Maria Fernanda , Macedo Perez Marysol , Alonso de León María Teresa , Berumen Glinz Cristina , Pérez Rubio Jimena , Vega Memije Maria Elisa , Asz Sigall Daniel , Barrera Ochoa Carlos
Published: February 2025

Androgenetic alopecia (AGA) is a type of hair loss that often manifests as male or female pattern baldness. In women, androgenetic alopecia resembling male-pattern baldness can occur in conditions of hyperandrogenism, such as congenital adrenal hyperplasia or ovarian and adrenal tumors, which are exceedingly rare, occurring in approximately 0.2% of cases. We report a 62-year-old female exhibiting hair loss and hirsutism that began over a decade ago. The medical examination reveals hirsutism on the face, abdomen, and chest, and hair loss in the fronto-parieto-occipital region, with a male pattern distribution consistent with grade VII on the Hamilton scale. Trichoscopy revealed loss of follicular openings, single follicular units, miniaturized hairs, and perifollicular brown halo. Laboratory tests indicated a total testosterone level of 10.15 ng/ml. An abdominal CT scan revealed bilateral adrenal adenomas, which were subsequently treated with laparoscopic radical adrenalectomy. In postmenopausal women, a new-onset state of hyperandrogenism may lead to virilizing symptoms, such as male-pattern alopecia, when testosterone levels exceed 5 nmol/L, necessitates immediate investigation to exclude an androgen-producing tumor, which typically normalizes swiftly within weeks post-surgery, while symptoms of androgen excess gradually diminish following the normalization of testosterone levels, as observed in our case.
Pediatric DTC Genetic Testing for Adult-Onset Inherited Cancer Risk: The Perspectives of High-Risk Parents
Authors: Kilbride Madison K. , Peshkin Beth N. , Hamilton Jada G. , Brower Jamie , Ovadia Hannah , Ross Lainie Friedman , Sacca Rosalba , Tarini Beth , Domchek Susan M. , Vittone Sarah , Sleiman Marcelo M. , Yockel Mary Rose , Salafia Caroline , Isaacs Claudine , Wilfond Benjamin S. , Statman Muriel R. , Tercyak Kenneth P.
Published: February 2025

Introduction
Despite guidelines discouraging pediatric genetic testing for adult-onset hereditary cancer risk, direct-to-consumer (DTC) companies make them available to children’s parents. This study examined the perspectives of high-risk parents towards such testing.
Methods
Interviews were conducted with N=30 parents (children ages 10-21) carrying pathogenic variants in cancer-causing genes available for detection through DTC tests. Interviews were analyzed inductively using a standardized methodology to identify prominent themes.
Results
Three major themes were identified: 1) high-risk parents’ motivations for pediatric genetic testing, 2) risks and benefits of pediatric genetic testing, and 3) parental involvement of children in decision-making about testing. Although only n=5 parents (17% of the sample) reported that their children were genetically tested (n=3 through a DTC company, n=2 through a clinician), 73% endorsed pediatric genetic testing for general health reasons. Many parents (53%) expressed a preference for clinical testing over DTC testing. While parents recognized the limits of DTC testing, some (40%) expressed that it should remain available to high-risk parents for the purpose of identifying cancer risks in their children. Children’s maturity (70%), interest in testing (77%), and anticipated responses to testing (43%) were cited as important decisional considerations.
Conclusion
Few high-risk parents utilized DTC testing for their children. Parents generally preferred the prospect of clinical testing, but some believed DTC testing should be an option available to families. Clinicians should discuss the risks and benefits of pediatric genetic testing, including DTC, with high-risk parents. This may facilitate more informed decision-making that minimizes potential harms.
The French Neuroendocrinology is enriched by its diversity
Authors: Vaudry David
Published: February 2025

No abstract
Single intraluminal delivery of a nitric oxide-donor results in inhibition of intimal thickening in the rabbit femoral artery
Authors: Böttger Priyanka , Grosser Tilo , Ibe Waltraut , Boissel Jean-Paul , Lindemann Stephan , Werdan Karl , Schwertz HansJörg , Darius Harald , Buerke Michael
Published: February 2025

Vascular smooth muscle cell proliferation and vascular homeostasis is thought to be regulated by nitric oxide and prostaglandins.
We examined the effect of exogenous linsidomine, a NO releasing compound, in a model of balloon injury iliac arteries of rabbits. On the cellular levels NO can exert effects like cellular survival, growth and proliferation inhibition.
Smooth muscle cell (SMC) proliferation was quantified as change of intima-media-ratio. Linsidomine injection or its vehicle was performed with an infusion-balloon catheter directly into the vessel wall. Balloon angioplasty resulted in a significant increase of intima-media-ratio during three weeks. Linsidomine treatment decreased the intima media ratio significantly (0.65±0.05 vs 1,2±0.2 intima-media-ratio, p<0.05). However, control vessels had an intima media ratio of 0.15±0.02. This effect was similar to NOS-2 transfected vessels following angioplasty. In in vitro experiments linsidomine inhibited significantly and dose-dependently rabbit smooth muscle cell proliferation measured by BrdU incorporation. Further linsidomine increased rate of apoptotic SMC’s, however this effect was p53 independent.
Simultaneous angioplasty of the rabbit iliac artery and direct injection of linsidomine into the vessel wall seem to be an effective strategy to reduce neointima formation. Despite single administration, local application of linsidomine resulted in potent inhibition of intima proliferation.
Miniglossário de termos agronômicos: português para inglês
Authors:   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz, Pedroso Rafael Munhoz , Dressano Ana Júlia Faganello ,   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz
Published: February 2025

A capacidade de comunicar-se de maneira eficiente na língua inglesa é hoje essencial a muitos profissionais ligados ao setor agrícola, e depende em grande parte de um vocabulário correto e extenso. Seja para manter-se atualizado sobre avanços na área através da leitura de revistas científicas internacionais ou ainda mesmo a comunicação direta com nativos da língua inglesa, o uso correto de termos técnicos é primordial. O objetivo deste miniglossário de termos agronômicos é oferecer uma rápida resolução de dúvidas e proporcionar auxílio na identificação da versão de palavras em português para o inglês, de maneira correta e eficiente. Esta obra integra a Coleção ABCD Agenda 2030 e alinha-se ao ODS 2 - Fome zero e agricultura sustentável (Objetivos de Desenvolvimento Sustentável).
Dosimetria das sanções no Tribunal de Contas da União: contribuições para a construção de um modelo normativo
Authors: Brito Thiago da Cunha
Published: February 2025

This article aims to contribute to constructing a normative model of the dosimetry and individualized application of sanctions in the Accounting Courts, promoting legal certainty and the predictability of decisions made by the Courts, as well as guaranteeing the effectiveness of the respective punitive decisions. To this end, the study begins with the presentation of the sanctioning powers and sanctions applicable by the Federal Accounting Court, then highlights the importance of regulating the matter within the scope of the Accounting Court. Finally, the work proposes a normative dosimetry model in sanctioning processes. It considers the legal assets protected by external control bodies and the purposes of their respective actions as guidelines for defining the criteria for the individualized application of the sanction in the model.
Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions
Authors: Arunothayaraj Sandeep , Egred Mohaned , Banning Adrian P. , Brunel Philippe , Ferenc Miroslaw , Hovasse Thomas , Wlodarczak Adrian , Pan Manuel , Schmitz Thomas , Silvestri Marc , Erglis Andreis , Kretov Evgeny , Lassen Jens Flensted , Chieffo Alaide , Lefèvre Thierry , Burzotta Francesco , Cockburn James , Darremont Olivier , Stankovic Goran , Morice Marie-Claude , Louvard Yves , Hildick-Smith David
Published: February 2025

BACKGROUND:

The optimal coronary stenting technique for true left main bifurcation lesions is uncertain. EBC MAIN (European Bifurcation Club Left Main Trial) aimed to evaluate clinical outcomes of a stepwise provisional strategy compared with a systematic dual-stent approach.

METHODS:

EBC MAIN was a randomized, investigator-initiated, open-label, multicenter, parallel-group trial conducted across 35 hospitals in 11 European countries. A total of 467 participants undergoing percutaneous coronary intervention for unprotected true left main bifurcation lesions were randomly assigned to the stepwise provisional strategy (n=230) or an upfront dual-stent approach (n=237). The mean (SD) age was 71 (10) years and 23% of participants were women. The primary end point was a composite of major adverse cardiac events, defined as all-cause mortality, all myocardial infarction, or clinically driven target lesion revascularization. Events were adjudicated by an independent clinical events committee and all analyses were by the intention-to-treat principle.

RESULTS:

At 3 years, the primary end point occurred in 54 of 230 (23.5%) stepwise provisional and 70 of 237 (29.5%) dual-stent patients (hazard ratio, 0.75 [95% CI, 0.53–1.07];
P
=0.11). There was no significant difference in all-cause mortality (10.0% versus 13.1%) or myocardial infarction (12.2% versus 11.0%). However, target lesion revascularization was significantly lower in the stepwise provisional group (8.3% versus 15.6%; hazard ratio, 0.50 [95% CI, 0.29–0.86];
P
=0.013). In this population, the mean side vessel diameter by quantitative angiography was 2.9 mm, and median side vessel lesion length was 5 mm. Significant interactions were identified between the assigned bifurcation strategy and both side vessel diameter and lesion length with respect to the primary outcome (
P
=0.009 and
P
=0.005, respectively), with smaller vessels (<3.25 mm diameter) and shorter lesions (<10 mm length) favoring the provisional approach.

CONCLUSIONS:

In a European population with true left main stem bifurcation coronary disease requiring intervention, there was no difference in major adverse cardiovascular events between stepwise provisional and systematic dual-stent strategies at 3 years. Target lesion revascularization was significantly less frequent with the stepwise provisional approach, which should be the default strategy for noncomplex left main bifurcation coronary intervention.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02497014.
Efficacy of Irbesartan in Celiprolol-Treated Patients With Vascular Ehlers-Danlos Syndrome
Authors: Jeunemaitre Xavier , Mousseaux Elie , Frank Michael , Adham Salma , Pitocco Francesca , Billon Clarisse , Ben Yakhlef Molka , El Hachmi Mohamed , Bura-Rivière Alessandra , Lapébie François-Xavier , Le Hello Claire , Laneelle Damien , Seinturier Christophe , Dieterich Klaus , Lambert Marc , Dupuis-Girod Sophie , Zuily Stéphane , Bal-Theoleyre Laurence , Boulon Carine , Henneton Pierrick , Lu Estelle , Denarié Nicolas , Boutouyrie Pierre , Mirault Tristan , Chatellier Gilles , Azizi Michel
Published: February 2025

BACKGROUND:

Vascular Ehlers-Danlos syndrome is a rare genetic disorder characterized by defective type III collagen and a high risk of arterial morbidity and mortality. Several cardiovascular drugs are used for treatment, including celiprolol, but no controlled trial in this condition has been conducted to date. We hypothesized the benefit of the addition of an angiotensin II receptor blocker.

METHODS:

A multicenter, randomized, placebo-controlled trial was conducted to assess the efficacy and safety of the angiotensin II receptor blocker irbesartan in adults with vascular Ehlers-Danlos syndrome on stable background celiprolol therapy. Patients were randomized 1:1 to receive irbesartan (150 mg/day titrated to 300 mg/day) or placebo for 2 years. The composite primary outcome was defined as any vascular Ehlers-Danlos syndrome–related fatal or nonfatal arterial event or any new or worsening arterial lesions detected by systematic head-to-pelvis computed tomography angiography or peripheral arterial duplex ultrasound at different time points, using a time-to-first-event analysis.

RESULTS:

Twenty-nine participants (62% female; 40.3±11.3 years of age) were randomized to irbesartan, and 28 (64% female; 40.7±11.0 years of age) were randomized to placebo. The composite primary outcome occurred in 8 of 29 patients (27.6%) receiving irbesartan versus 15 of 28 patients (53.6%) receiving placebo (hazard ratio, 0.42 [95% CI, 0.17, 0.99];
P
<0.05). The risk of recurrent symptomatic or nonsymptomatic arterial events was lower with irbesartan than with placebo (risk ratio, 0.37 [95% CI, 0.19, 0.68];
P
=0.002). A reduction of progression of arterial lesions was observed at all sites. Irbesartan significantly reduced systolic blood pressure compared with placebo (baseline-adjusted difference of 5.4 mm Hg [
P
<0.001]), but no relation was observed with the reduction of the primary composite outcome. Eleven episodes of irbesartan-related hypotension were recorded, leading to a downtitration in 4 patients.

CONCLUSIONS:

Compared with placebo, irbesartan reduced the risk of severe symptomatic and asymptomatic arterial events in patients with vascular Ehlers-Danlos syndrome on background celiprolol therapy.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02597361.
Lightyears: Auditory Navigation through Coppice’s Draw Agreement
Authors: Cuéllar Noé , Kramer Joseph
Published: February 2025

Elucidating the structure of its retrospective triptych Draw Agreement (2023), Coppice (Noé Cuéllar and Joseph Kramer) overviews the techniques driving its musical experimentation between 2009 and 2022. Rich in sound, musical, technological, and listening concepts, these notes serve to accompany the navigation of Coppice’s music as referenced from the three-part construct, while pointing to other related works. Through documentation and metaphor, Coppice’s sonic thinking identifies recurring themes, culminating in a spatiotemporal synthesis of actuality and simulation in an increasing convolution of auditory reflexivity. In parceling this 13-year experimental musical object, Coppice attains and continues building upon an auditory perspective that engages postphenomenological embodiment, shifting spatiotemporal values and creative mediative processes reflective of artistic, technological, and auditory cultures today.
The Splendor of Plainness: A Transformation of the Process of Qi as Expressed in the Generative Artwork UKON
Authors: Hsieh Chi-Min , Chou Hsiao-Ching
Published: February 2025

The authors thoroughly examine the creative process behind UKON, which uses computer simulation to reinterpret the Song Dynasty’s aesthetic of “plainness.” By treating random numbers as representations of Qi, the artwork undergoes a transformation that both complicates and simplifies its visual elements. This approach not only transcends simple visual depiction but also reflects a profound exploration of “the extreme splendor of plainness,” capturing its essence in a contemporary form. The work showcases the artist’s deep understanding of traditional aesthetics and illustrates how modern technology can reinvent these concepts as a new visual language.
Porous Embodiment and Poetic Knowledge: An Emergent Dialogue Between a Puppetry Artist and a Neuroscientist
Authors: Tsaplina Marina , White Leonard E.
Published: February 2025

This article illustrates a collaboration-in-formation between a performing artist and a neuroscientist. The authors focus on the early clarification of cross-disciplinary language and their recognition of the frameworks, overlaps, and divergences between how puppetry animation and neuroscience approach body, breath, imagination, disability, embodiment, consciousness, and research itself. The authors briefly discuss the creative process in puppetry performance and ask questions about what normative assumptions exist in neuroscience and how they interface with the authors’ perspectives as researcher-practitioners.
Breathing Life into Slime: The Creation of Kinetic Sculptures from Non-Newtonian Fluids
Authors: Wu Yuan-Shao , Hsu Chun-Cheng , Yen Wei-Chen , Hsu Chiao-Ni , Wu Kuan-Ju
Published: February 2025

The authors explore the use of slime, a non-Newtonian fluid, as a medium for creating kinetic sculptures. Inspired by a children’s workshop, the authors experimented by creating forms with slime bubbles. They describe how they utilized the science behind the material to craft sculptures and how the interactions of bubbles create sculptural bodies and lifelike movements. The article further introduces the mechanism behind the creation, which led to several methods for creating slime sculptures. Through exhibitions in Taiwan and at the Ars Electronica Festival, the authors share insights into audience reactions and how these sculptures elicit visual, auditory, and tactile experiences.
Semi-Automatic Generation of Shape-Specific Dynamic Projection Mapping onto Plants and Animals
Authors: Sueyoshi Tomoki , Morimoto Yuki
Published: February 2025

Targets of projection mapping have recently been extended beyond inanimate objects to include plants and animals. However, it is difficult to project images onto such dynamic and deformable targets. We propose systems that perform real-time tracking with image processing and generate aesthetic effects and animations according to the target area and interactions with the targets. Our results showcase the potential of dynamic projection mapping onto plants and animals in art and entertainment.
Microbial safety of industrially reared Hermetia illucens larvae and frass: bacterial dynamics and prevalence of antibiotic resistance genes
Authors: Ravoitytė B. , Varnelytė G. , Lukša-Žebelovič J. , Tracevičius S. , Burokas A. , Baltriukienė D. , Servienė E.
Published: February 2025

The larvae of the black soldier fly (BSFL) can efficiently convert food waste into valuable biomass. They are also an alternative source of fat, protein, and chitin, but little is known about the total microbiota of the whole BSFL and its impact on the microbiological safety of food and feed. This study was conducted to determine bacterial microbiota dynamics of the whole BSFL and frass residues during the industrial rearing process, including the effects of thermal treatment, counts and identification of cultivable bacteria, and the presence of antibiotic resistance genes (ARGs). The second and the fourth instar larvae, frozen and dried fourth instar larvae, and frass samples were examined. The composition of the total bacterial microbiota in BSFL samples was similar and dominated by Proteobacteria while in frass Firmicutes prevailed. The lowest diversity was observed in the second instar larvae and the highest in the frass. The samples showed a relatively low bacterial community diversity. In agreement with the analysis of the total microbiota, the isolated cultivable bacterial strains were members of Proteus, Providencia, Morganella, Staphylococcus, Klebsiella, Enterococcus, and Bacillus genera. The counts of cultivable bacteria increased during the growth of larvae and were similar in the fourth instar larvae and frass residues. Dried larvae had the lowest number of viable counts and were dominated by spore-forming bacteria. The determined viable aerobic counts meet the criteria for edible insects. ARGs conferring resistance to aminoglycosides (aac-aph), β-lactams (blaZ), erythromycin (ermA), tetracycline (tetM, tetW), and vancomycin (vanA, vanB) were detected by PCR, with the highest diversity and detection rate in frass. The gene tetM was the most widespread and detected in all groups of the tested samples. The results of this work extend the scarce knowledge about the dynamics of microorganisms and ARGs in the industrial-scale food waste upcycling process by BSFL.
British Military Music in Battle during the Napoleonic Wars
Authors: O’Keeffe Eamonn
Published: February 2025

This article investigates the presence and significance of British military music in action during the French Revolutionary and Napoleonic Wars. Based on a diverse body of sources, including contemporary military manuals, archival collections, and soldiers’ memoirs, it argues that regimental bands did not normally strike up in the heat of battle. Highland pipers, on the other hand, were celebrated for playing in combat. Bugles and trumpets were crucial for relaying tactical commands to dispersed skirmishers and cavalrymen, but British drummers were less often heard under fire. The article also explores the non-musical duties of drummers and bandsmen in combat, including their contributions as stretcher-bearers. It ends by highlighting music’s importance in shaping how battles were remembered, drawing on evidence from regimental commemorations and Victorian military art.
Prof. Balibar’s X-Mutant Transindividuals
Authors: Hall Joshua M.
Published: February 2025

As I have explored elsewhere, the Birmingham Philosophy Guild, which my former students and I re-founded in 2012, is a team of community members who engage in theoretical discussion, support group self-cultivation, and community activism. To further promote the guild as a catalyst for progressive social change, the present article connects it to both the popular cultural phenomenon of the “X-Men” – to make the guild more appealing to students and laypeople – and to the cutting-edge contemporary French philosophy of Étienne Balibar – to make the guild more appealing to professors and culture workers. Moreover, the article connects these low- and high-brow phenomena to each other as well, thereby illustrating the political relevance of the lower, as well as a weakness in the higher, pursuant to social justice activism today.
‫الأثر الإسلاميّ في كتاب تعبير الرؤيا لعبد الله بن مسلم بن قتيبة (ت ‫276‬/889)‬
Authors: فاغنر مارك
Published: February 2025

المستخلص

‫لا يبدو واضحًا دور كتاب تعبير الرؤيا لابن قتيبة (ت ‫276‬/889) في تحويل علم التعبير إلى واحد من العلوم الإسلاميّة. يؤكّد أومبرتو تشيكيتي الدورَ التحويليّ الذي قام به ابن قتيبة في ”أسلمة“ هذا العلم وفق المذهب السُّنّي وبطرق مختلفة. ومع أنّ ابن قتيبة قد عبّر عن آرائه الخاصّة بالطريقة الصحيحة لتعبير الرؤى، وتميّز بتأويلاته لرموز المنامات، فإنّ مقاربته لا تُختزل بـ”الأسلمة.“ يُعَدّ ابن قتيبة شخصيّة متناقضة، فهو المتحدِّث الرسميّ النموذجيّ للإسلام السُّنّي الناشئ، وهو أيضًا جامِع فضوليّ لموضوعات تبدو غير إسلاميّة (وغير عربيّة). ويمثّل كتاب تعبير الرؤيا الجانب الثاني الأكثر غموضًا. يؤدّي حصر أجندة ابن قتيبة بمشروع ”الأسلمة“ إلى قرار تحريريّ مضطرب، وهو إقصاء إحدى مخطوطتي الكتاب بوصفها غير موثوقة. والأفضل اعتماد رأي م. ج. كستر الذي يجد تكاملًا بين المخطوطتين.‬
A Typology of Fish Names in Kumzari
Authors: Anonby Erik , Ali Al Kamzari AbdulQader Qasim
Published: February 2025

In contrast to the desolate environments that characterize much of the Arabia’s surface, the surrounding waters are home to a high level of biological diversity, including hundreds of species of fish. This is particularly true of the seas around the Musandam Peninsula of far north-eastern Arabia, where shallow gulf waters give way to open ocean. This chapter provides an inventory, description and analysis of fish names in Kumzari, an endangered language spoken in a handful of towns and city neighbourhoods in the wider region. The scope of fish as a semantic category is first delimited, followed by comments on the defining and labelling of fish species. The central section of the article proposes a typology of Kumzari fish names based on factors including association with other species, descriptions of their physical appearance and other, more complex kinds of descriptive labels. The article closes with reflection on fish names in their wider linguistic context: structural characteristics, use of fish names elsewhere in the lexicon, and the relevance of fish names for understanding the history of the Kumzari language. An explanatory lexicon of the 198 fish names in the data is provided as an appendix.
Harvesting the Sea in Soqoṭra
Authors: Morris Miranda J. , Walīd al-Soqoṭri Mubārak ˁĪsa , Taḥkí al-Soqoṭri Aḥmad Saˁd
Published: February 2025

This chapter discusses how the seas were harvested around Soqoṭra, the main island of the Soqoṭra Archipelago, in the days before fishermen owned sea-going boats and still had to make their own fishing equipment. The aim of the chapter is to provide a snapshot of how islanders made use of the sea before the fisheries became a modern commercial enterprise in the 1990s. Prior to this, fishing was a seasonal activity for many islanders, though there were those who would not eat fish at all, and for others who owned no land it was a subsistence activity. Along the northern coast there were also full-time fishermen, in pursuit of the larger fish that they salted and dried to trade with the boats that called in on their way to and from the Gulf, Oman and East Africa. The study’s co-authors, the late Mubārak ˁĪsa Walīd and the late Aḥmad Saˁd Taḥkí, represented both the seasonal tradition and the full-time one. The chapter is followed by a series of transcribed, translated and annotated Soqotri-language material collected from Aḥmad Saˁd Taḥkí between 1990 and 2010, either during author Miranda Morris’s time spent on the island or during his visits to work with her in the UK.
Exoplanets and Their Characterization in the Environment of Galaxy Formation
Authors: Tolasa Diriba , Furi Adugna
Published: February 2025

The exploration of exoplanets has become a crucial domain in astrophysics, particularly in understanding their formation and evolution within the broader framework of galaxy formation. This paper offers a comprehensive analysis of the current methodologies employed for exoplanet detection and characterization, highlighting the intricate relationships between galactic dynamics and planetary systems. We introduce an innovative approach that integrates numerical simulations with analytical models to investigate how various galactic environments influence the properties of exoplanets. Our findings reveal significant correlations between the attributes of exoplanets and their host galaxies, suggesting that the conditions conducive to planetary formation are deeply interconnected with the galactic context. In particular, we examine how factors such as the density of surrounding gas and dust, the presence of nearby stars, and the gravitational effects of dark matter shape the characteristics of emerging planetary systems. Our analysis demonstrates that understanding these interactions is essential for developing comprehensive models of planetary formation and evolution. The results indicate that exoplanets do not form in isolation but are significantly influenced by the dynamics of their host galaxies. Additionally, our study underscores the importance of advanced observational techniques, including those enabled by the James Webb Space Telescope (JWST), which are poised to revolutionize the field of exoplanet research. By combining theoretical frameworks, numerical simulations, and observational data, this research contributes to the ongoing discourse on exoplanet characterization and the broader implications for galaxy formation. Ultimately, we aim to enhance our understanding of exoplanets, providing insights that could inform future studies on the potential for habitability and the existence of life beyond Earth.
Using Artificial Intelligence Techniques to Innovation 3D Designs for Occasion Clothes Inspired by the Fatimid Era
Authors: Sabbahi Basma
Published: February 2025

Intelligence has been used in various fields worldwide, and many studies have emerged related to artificial intelligence and its effective and essential role in the field of ready-made clothing in all its various stages, This research aims in general to study and analyze one of the most important applications of artificial intelligence, which is (Leonardo.AI), and to benefit from it in the field of designing occasion clothes inspired by the Fatimid era. The importance of the research lies in presenting an analytical study of one of the most important applications of artificial intelligence (Leonardo.AI) - enriching the local market with designs for occasion clothes inspired by the Fatimid era using one of the most important applications of artificial intelligence - enriching the field of fashion design and the digital library with a study linking it to one of the most important applications of artificial intelligence (Leonardo. AI). The result of this research: There are no statistically significant differences between the averages of the opinions of the arbitrators on the designs in employing the elements and foundations of the proposed design for occasion clothes inspired by the Fatimid era using the artificial intelligence application, and between the averages of the opinions of the arbitrators on the designs In the aesthetic aspect of the proposed design of occasion clothes inspired by the Fatimid era using the artificial intelligence application, between the average opinions of the arbitrators on the designs in the functional aspect of the proposed designs for occasion clothes inspired by the Fatimid era using the artificial intelligence application, and between the average opinions of consumers on the designs in the proposed designs for occasion clothes inspired by the Fatimid era using the artificial intelligence application.
Determination of the Effective Microstructural Unit in Relation to the Weld Metals Brittle Fracture Resistance
Authors: Holovko Viktor , Kostin Valery , Korolenko Daniil , Reminyi Maksym
Published: February 2025

Metallographic studies of the high-strength, low-alloy steels weld metal structure show that the cracks in the structure can pass through several grains, or stop at the grain boundary or in the middle of the grain. Resistance to weld metal brittle fracture is usually associated with the grain size in its structure. Recently, works have appeared in the scientific and technical literature, in which instead of grain sizes, that is, the solid solution region delineated by the phase boundary, it is proposed to determine the influence of the solid solution region with a close orientation of ferrite formations. Purpose of the article: To clarify the grain size definition for the welds metal structure. Recently, works have appeared in the scientific and technical literature, in which instead of grain sizes, that is, the solid solution region delineated by the phase boundary, it is proposed to determine the influence of the solid solution region with a close orientation of ferrite formations. Key Idea: For weld metal, the structural grain size is determined by the disorientation index at the grain boundary. The article presents a critical analysis of the authors results concerning the point of view on the validity of such an approach to assessing the influence of microstructure on the metal of welds mechanical properties. Conclusion: When analyzing the weld metal structure influence on the mechanical properties, the grain size must be determined using the disorientation parameter at the grain boundary.
The Evolution of Self-Healing Electrodes: A Critical Review of Nanomaterial Contributions
Authors: Ibrahim Oresegun , Oluwadunsin Josiah , Antwi Moses , Mekunye Francis , Oluwatobi Michael , Olorunfemi Abiodun , Obanla Oyinlola , Abdul-Rahman Mohammed , Babalola Kehinde , Babalola Oladipupo
Published: February 2025

The ability of self-healing electrodes to withstand electrical breakdown at high electric fields has drawn a lot of interest to them in recent decades. Applications include electronic skins, sensors, supercapacitors, and lithium-ion batteries have resulted from the integration of conductive nanoparticles in flexible self-healing electrodes. Prior self-healing electrodes based on hydrogels and polymers had low strengths and conductivities. However, nanomaterials offer vast surface area, abundant functional groups, and special qualities that speed up the healing process. Self-healing electrodes, capable of autonomously repairing damage and extending their operational lifespan, represent a paradigm shift in material science and electronic device design. This review paper charts the remarkable evolution of self-healing electrodes, with a particular focus on the pivotal role of nanomaterials in driving this progress. The emergence of self-healing concepts is then discussed, encompassing both intrinsic mechanisms inherent to specific materials and extrinsic approaches that rely on the integration of healing agents. We explore how the distinct physicochemical properties of nanomaterials, such as their high surface area, adjustable conductivity, and catalytic activity, have been used to give electrodes the ability to cure themselves. Specific examples showcasing the successful incorporation of nanomaterials like carbon nanotubes, graphene, MXenes, and metallic nanoparticles into various electrode architectures are presented. The underlying self-healing mechanisms, ranging from reversible chemical bonding to dynamic supramolecular interactions, are elucidated. Furthermore, we critically assess the performance enhancements achieved through nanomaterial integration, including improved mechanical robustness, enhanced electrical conductivity, and extended cycling stability.