bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphology of the bronze objects from the Pinchuga-6 burial ground
Authors: Senotrusova P.O. , Khavrin S.V. , Ekkerdt A.A. , Mandryka P.V.
Published: March 2024

The article is concerned with bronze objects of the end of the Early Iron Age from the fully excavated burial ground of Pinchuga-6 in the Lower Angara River region. The cemetery is dated to the 3rd–4th centuries BC. All burials were made following the rite of burial on the side. Three categories of copper alloy products have been distinguished: belt set parts, jewelry, and cult castings. The components of the belt sets include flat openwork buckles, hoops and bird-shaped overlays. Flat openwork buck-les have no analogues in the neighbouring territories. They appeared on the basis of the circle of post-Hunnic cultures of South-ern Siberia and were used in the Angara taiga until the mid-1st millennium AD. One belt hoop with volutes and an openwork patch is of a typical Tashtyk Culture appearance. At the end of the Early Iron Age, bird-headed belt plates were used across a vast territory that stretched from the Ural Mountains in the west to the banks of the Yenisei and Angara Rivers in the east. The jewelry includes tubular cast and spiral beads, stripes and pendants. The majority of items are multi-functional — they could be worn different ways. All of them were widespread in the first half of the 1st millennium AD, and they do not have a clear cultural and chronological reference. At Pinchuga-6, various objects of cult casting were found, including ornitho-, zoo- and ichthyomor-phic images, and disks with a circular ornament. These items have similarities among the Ishim and Kholmogory collections, materials from the Aidashinskaya cave, and Tomsk and Ust-Abinsk burial grounds. Pinchuga-6 is currently the farthest north-eastern site where such objects have been found. The grave goods of the cemetery contain items of different cultural attribution made of copper-based alloys. In this single complex in the Angara River region, objects from Western Siberia, Khakass-Minusinsk depression, and, possibly, of local origin have been found. XRF analysis of the items has been carried out. Lead-tin and tin bronze prevail, although being in approximately equal quantities, individual objects are made of copper, a small amount of arsenic is traced in two buckles, one ornithomorphic image is cast from an alloy with a significant amount of silver. The clo-sest in this feature, as well as in the amount of tin and lead in the alloys, are the products of the Tomsk burial ground.
Metallographic study of non-ferrous metal products from the Maray 1 site of the Baitovo Cul-ture in the Lower Ishim River region
Authors: Tigeeva E.V.
Published: March 2024

The article examines non-ferrous metal products from the Baitovo Culture materials of the Early Iron Age hillfort of Marai 1. This settlement is located in the forest-steppe of the Ishim River region of Western Siberia. The upper building hori-zon marks the settlement of the Baitovo Culture dating to the 4th–2nd centuries BC. Metallographic analysis of 28 items was carried out using the Axio Observer D1m microscope (Zeiss). As a result, eight technological schemes characteristic for the metalworking activities of the Baitovo population have been identified. The study shows that prevailing were smithing tech-nologies in different temperature regimes for the production of non-ferrous metal objects (16 specimens, 57.2 %). The pref-erence was given to hot forging in the red-heat regime at 600–800°C (7 specimens, 25 %), cold forging with annealing (5 specimens, 17.8 %), as well as incomplete hot forging at 300–500°C (3 specimens, 10.7 %). Casting without further refine-ment was recorded in the microstructures of arrowheads, ingots and splashes (9 specimens, 14.2 %). Casting, followed by a slight degree of deformation (20–30 %), was noted in three cases. This scheme correlates with the metalworking traditions of the Itkul and Krasnoozerskaya Cultures, and it was dominant on the territory of the Tobol-Ishim region during the Early Iron Age. Such a low percentage of items related to it could be explained by the absence in Marai 1 of large items cast in moulds needing further refinement (knives, celts, etc.). A microstructural study confirmed the use of pure oxidized copper by the craftsmen of the Baitovo Culture, with characteristic inclusions of Cu–Cu2O eutectic, associated with the Ural production centres. Arrowheads and an ingot made of pure oxidized copper were probably a direct import from the territory of the Itkul Culture. Low-alloy tin and arsenic bronzes, coming from the metal production centres of Kazakhstan and Altai, were also used to the same extent for production of some tools and jewellery. The correlation between the type of product, composition of raw materials and technology of its manufacture has been revealed, which is most clearly manifested in arrowheads and awls. The use of high temperatures and significant degrees of compression (80–90 %) has been recorded in a number of cases, resulting in the appearance of rejects. Cracks of hot brittleness, as well as of cold brittleness, occurred in the process of technological cycle, carried out with an excess of the tensile strength of the metal.
The Strategy of Madrasah Development Amidst Globalization Challenges
Authors:   Universitas Islam Negeri Raden Fatah, Palembang, Indonesia, Firmansyah Firmansyah , Zuhdi Muhammad ,   Universitas Islam Negeri Syarif Hidayatullah, Jakarta, Indonesia, Karoma Karoma ,   Universitas Islam Negeri Raden Fatah, Palembang, Indonesia
Published: March 2024

As an educational institution born from the cradle of Islamic civilization, madrasahs have played a role in the advancement of the Muslim community in the past. However, in the midst of this era of globalization, madrasahs face complex challenges. This research aims to describe the development of madrasahs in the dynamics of Islamic education and the strategic steps madrasahs take in facing the era of globalization. This study is a literature review that uses documentation as the method of data collection, while the analysis technique employs inductive analysis. The results of this research indicate that in this era of globalization, madrasahs encounter two main challenges: 1) internal challenges, such as the low quality and competitiveness of madrasah graduates; and 2) external challenges, namely Islamophobia in the global community, especially in the West. To address internal issues, integrated improvements involving all elements of madrasah management need to be pursued. External issues need to be approached with a new marketing model that utilizes contemporary communication patterns to combat negative stigma against madrasahs and simultaneously create a positive trend towards the image of Islamic educational institutions and Islam itself.
Application of Shannon Entropy in Assessing Changes in Precipitation Conditions and Temperature Based on Long-Term Sequences Using the Bootstrap Method
Authors: TWARÓG Bernard Stanisław
Published: March 2024

In this paper, the Shannon entropy measure was used to assess changes in precipitation and temperature conditions. Due to the short, low-volume sequences of precipitation and temperature data analysed, a bootstrap method was used in the procedure for calculating Shannon entropy. The analysis used minimum and maximum values of monthly precipitation totals and monthly mean temperatures for 377 catchments distributed across the globe. A 110-year data series from 1901 to 2010 was analysed. Entropy values for the estimated parameters of the generalised extreme value distribution (GEV) were calculated for the adopted data. Entropy value calculations were performed for the left-hand constraint, based on minimum values, and for the right-hand constraint, based on maximum values. The applicability of Shannon's entropy measure in the analysis of climate change was demonstrated by allowing the degree of disorder and complexity of the distributions describing climate variables in the form of precipitation and temperature to be measured. This made it possible to obtain information on the directions of changes occurring with regard to minimum and maximum values in the field of monthly precipitation and mean temperatures in the analysed catchments. The study demonstrated the existence of Shannon entropy trends. The evaluation of entropy trends for precipitation and temperature sequences was performed using non-parametric tests. Mann -Kendall tests at the 5% significance level were used for trend analyses. The Pettitt test was performed to determine the point of change in trend for the rainfall and temperature data. The performed analysis was supported by graphical presentations.
Effects of a Topical Composition of Gaba and Microbial Chondroitin Sulfate on Mental Calmness and Brain Function
Authors: Ruggiero Marco
Published: March 2024

This article describes a novel topical composition constituted by gamma-amino butyric acid (GABA) and microbial chondroitin sulfate. This composition, formulated by the author and manufactured in a certified facility in the United States of America, exhibits potential for non-invasive intervention in anxiety management, sleep quality enhancement, and promotion of brain-related functions like meditation and nonlocal consciousness. The core component comprises GABA, a key inhibitory neurotransmitter within the central nervous system, complexed with a suitable carrier molecule, microbial chondroitin sulfate. This complexation aims to enhance transdermal absorption and optimize delivery of GABA to target tissues. The proposed mechanism of action involves modulation of GABAergic signal transduction pathways. Application of the topical composition allows GABA penetration into the skin and potentially deeper tissues, where it interacts with GABA receptors. This interaction leads to mental calmness and relaxation as assessed by electroencephalography. The influence of GABAergic signaling on brain circuits demonstrated in this article, when associated with meditation and nonlocal consciousness, suggests potential for the composition to support these practices. The advantage of such an approach consists in avoiding the potential systemic side effects associated with oral or injectable administration of GABA, anxiolytics or hypnotics. Furthermore, the combination of GABA and microbial chondroitin sulfate may offer synergistic benefits, potentially enhancing the overall biological effects. In conclusion, this article presents a novel topical approach for managing anxiety, enhancing sleep quality, and potentially facilitating meditation and nonlocal consciousness through modulation of GABAergic signaling pathways. While further research is necessary, the potential for a non-invasive and potentially side-effect-free intervention in these areas is promising.
Revisiting the use of the Gumbel distribution: A Frequency Analysis Perspective
Authors: Anghel Cristian-Gabriel , Ilinca Cornel
Published: March 2024

The manuscript presents the applicability of the Gumbel distribution in the frequency analysis of extreme events in hydrology. The advantages and disadvantages of using the distribution are highlighted, as well as recommendations regarding its proper use. A literature review was also carried out regarding the methods of estimating the parameters of the Gumbel distribution. Thus, for the verification of the methods, case studies are presented regarding the determination of the maximum annual flows and precipitations using nine methods for parameter estimation. The influence of the observed data lengths on the estimation of the statistical indicators, the parameters and the quantiles corresponding to the field of low annual exceedance probabilities (p <1%) is also highlighted. The results are compared to those obtained with the Generalized Extreme Value distribution, respectively the Burr and the Wakeby distributions with parameters estimated using the L-moments. The results highlight and reaffirm the statistical, mathematical and hydrological recommendation regarding the avoidance of using the Gumbel distribution in Flood Frequency Analysis and its use with reservations in the case of maximum precipitation, especially when the statistical indicators of the analyzed data are not close to the characteristic ones and unique to the distribution.
Antiviral Effect of Antimicrobial Peptoids and a Murine Model of Respiratory Coronavirus Infection
Authors: Lebedev Maxim , Benjamin Aaron , Kumar Sathish , Molchanova Natalia , Lin Jennifer S. , Koster Kent J. , Leibowitz Julian L. , Barron Annelise E. , Cirillo Jeffrey D.
Published: March 2024

New antiviral agents are essential to improving treatment and control of SARS-CoV-2 infections that can lead to the disease COVID-19. Antimicrobial peptoids are sequence-specific oligo-N-substituted glycine peptidomimetics that emulate the structure and function of natural antimicrobial peptides but are resistant to proteases. We demonstrate antiviral activity of a new peptoid (TM9) against the coronavirus, murine hepatitis virus (MHV), as a closely related model for the structure and antiviral susceptibility profile of SARS-CoV-2. This peptoid mimics the human cathelicidin LL-37, which has also been shown to have antimicrobial and antiviral activity. In this study TM9 was effective against three murine coronavirus strains, demonstrating the therapeutic window is large enough to allow use of TM9 for treatment. All three isolates of MHV generated infection in mice after 15 min of exposure by aerosol using the Madison aerosol chamber and all three viral strains could be isolated from the lungs throughout the 5-day observation period post-infection, with the peak titers on day 2. MHV-A59 and MHV-A59-GFP were also isolated from liver, heart, spleen, olfactory bulbs, and brain. These data demonstrate that MHV serves as a valuable natural murine model of coronavirus pathogenesis in multiple organs, including the brain.
Development of Municipal Energy Management as Trigger of Future Energy Savings
Authors: Bačovský Michal , Karásek Jiří , Kaločai Ladislav
Published: March 2024

Directive 2018/844/EU on energy efficiency claims almost 80% of final energy consumption in EU is used within the buildings. Subsequent Directive (EU) 2023/1791 introduced in 2023 expected 68% of the World population living in urban areas. Both Directives enhanced the role of energy management (EM) applied on the city buildings. The study introduces the development of energy management in Czech municipalities between the years 2009 and 2023. The main goal of this article is to present selected results of the unique national survey focused on the energy management in Czech municipalities conducted in 2023 and compare it with results of national surveys implemented in 2009 and 2018. The main method is the evaluation of deep survey conducted among the municipal representatives or energy managers in the past with the new survey conducted in 2023. The results show that EM became notably more important issue for the most Czech municipalities. The number of cities implementing EM significantly grew and the number of city energy managers increased too. On the other hand, the used potential of energy savings triggered by establishing EM is insufficient. This article should be applied to stress power of municipal EM in performing energy efficiency and RES projects and encouraging government to support municipal energy managers in their complex role.
Above the Sea of Fog: Dietary and Lifestyle Interventions for the Treatment of Depression
Authors: Halma Matthew , Plothe Christof , Marik Paul E
Published: March 2024

Antidepressants are among the most used medications in the US, with significant deleterious effects on people’s well-being. At any given time, depression impacts approximately 1 in 10 Americans, causing wide and broad societal costs. Interest is developing for non-pharmacological treatments and preventative measures. We summarize the literature on non-invasive dietary and lifestyle approaches for treating depression, including recent work with the psychedelic treatment of depression. This review aims to inform future research and treatment programs for depression. This review provides an evidentiary summary of integrative therapeutic approaches for depression.
Coaxial Fibres Incorporated with Phase Change Material for Thermoregulation Applications
Authors: Hammes Nathalia , Pinheiro Claver , Segundo Iran Rocha , Homem Natália Cândido , Silva M. M. , Felgueiras Helena P. , Soares Graca M.B. , Freitas Elisabete , Costa Manuel F. M. , Carneiro Joaquim Alexandre O.
Published: March 2024

Nowadays, the growing concern about improving thermal comfort in textiles, asphalt pavements and buildings has stimulated research into phase change materials (PCMs). However, the incorporation of PCMs directly causes mechanical impacts. Therefore, this study herein reported focuses on designing coaxial phase change fibres using commercial cellulose acetate (CA) or recycled CA obtained from cotton fabrics (CAt) as a coating and polyethylene glycol (PEG) 2000 as a core. The phase change fibres (PCF) were produced by wet spinning, varying the parameters: (i) CA concentration, molecular weight and source (virgin versus recycled); and (ii) PEG concentration and ejection. For phase change recycled fibres (PCFt), PEG concentration and ejection were varied. The fibres were assessed for their optical, chemical, thermal and mechanical properties. Bright-field microscopy images and Scanning Electron Microscopy (SEM) micrographs proved the coaxial structure. Fourier Transform Infrared spectroscopy (FTIR) confirmed the presence of PEG in the core. Thermogravimetric Analysis (TGA) proved the ability of PCFs to tolerate high temperatures. Differential Scanning Calorimetry (DSC) attested to the presence of PEG2000 peaks, since their melting points were close to those of virgin PEG2000, with a slight change in the PCFs and PCFts caused by the protective sheath of CA and CAt.
Mutation Trajectory of Omicron SARS-CoV-2 Virus
Authors: Konishi Tomokazu , Takahashi Toa
Published: March 2024

Since 2019, the SARS-CoV-2 virus has caused a global pandemic, resulting in widespread infections and ongoing mutations. Analysing these mutations is essential for predicting future impacts. Unlike influenza mutations, SARS-CoV-2 mutations displayed distinct selective patterns that were concentrated in the spike protein and small ORFs. In contrast to the gradual accumulation seen in influenza mutations, SARS-CoV-2 mutations lead to the abrupt emergence of new variants and subsequent outbreaks. This phenomenon may be attributed to their targeted cellular substances; unlike the influenza virus, which has mutated to evade acquired immunity, SARS-CoV-2 appeared to mutate to target individuals who have not been previously infected. The Omicron variant, which emerged in late 2021, demonstrates significant mutations that set it apart from previous variants. The rapid mutation rate of SARS-CoV-2 has now reached a level comparable to 30 years of influenza variation. The most recent variant, JN.1, exhibits a discernible trajectory of change distinct from previous Omicron variants.
Bioactive Compounds from Pigmented Corn (Zea mays L.) and Their Effect on Health
Authors: Sánchez-Nuño Yaír Adonaí , Zermeño-Ruiz Martín , Vázquez-Paulino Olga Deli , Nuño Karla , Villarruel López Angélica
Published: March 2024

Pigmented corn is a gramineae food of great biological, cultural and nutritional importance for many Latin American countries, with more than 250 breeds in the American continent. It confers a large number of health benefits due to its diverse and abundant bioactive compounds. In this narrative review we decided to organize the information on the nutrients, bioactive compounds and phytochemicals present in pigmented corn, as well as their effects on human health. Phenolic compounds and anthocyanins are some of the most studied and representative compounds in these grasses, with a wide range of health properties, mainly the reduction of prooxidant molecules. Carotenoids are a group of molecules belonging to the terpenic compounds, present in a large number of pigmented corn breeds, mainly the yellow ones, whose biological activity incorporates a wide spectrum. Bioactive peptides can be found in abundance in corn, having very diverse biological effects that include analgesic, opioid, antihypertensive, etc. activity. Other compounds with biological activity found in pigmented corn are resistant starches, some fatty acids, phytosterols, policosanols, phospholipids, ferulic acid and phlobaphenes, as well as a great variety of vitamins, elements, and fibers. This review aims to disseminate and integrate the existing knowledge on compounds with biological activity in pigmented corn, in order to promote their research, interest and use by scientists, nutrition professionals, physicians, industries and the general population.
Endophytic Fungi for Crops Adaptation to Abiotic Stresses
Authors: Morales-Vargas Adan Topiltzin , López-Ramírez Varinia , Alvarez-Mejia Cesar , Vázquez-Martínez Juan
Published: March 2024

Endophytic fungi (EF) have emerged as promising modulators of plant growth and stress tolerance in agricultural ecosystems. This review synthesizes current knowledge on the role of EF in en-hancing crop adaptation to abiotic stress. Abiotic stresses, such as drought, salinity, and extreme temperatures, pose significant challenges to crop productivity worldwide. EF have shown re-markable potential in alleviating the adverse effects of these stresses. Through various mechanisms including synthesis of osmolytes, production of stress-related enzymes, and induction of plant de-fense mechanisms, EF enhance plant resilience to abiotic stressors. Moreover, EF promote nutrient uptake and modulate hormonal balance in plants, further enhancing stress tolerance. Recent ad-vancements in molecular techniques have facilitated the identification and characterization of stress-tolerant endophytic fungal strains, paving the way for their utilization in agricultural prac-tices. Furthermore, the symbiotic relationship between EF and plants offers ecological benefits, such as improved soil health and reduced dependence on chemical inputs. However, challenges remain in understanding the complex interactions between EF and host plants, as well as in scaling up their application in diverse agricultural systems. Future research should focus on elucidating the mechanisms underlying endophytic fungal-mediated stress tolerance and developing sustainable strategies for harnessing their potential in crop production.
A Pilot Phase 2 Randomized Trial to Evaluate the Safety and Potential Efficacy of Etravirine in Friedreich Ataxia Patients
Authors: Paparella Gabriella , Stragà Cristina , Pesenti Nicola , Dal Molin Valentina , Martorel Gian Antonio , Merotto Vasco , Genova Cristina , Piazza Arianna , Piccoli Giuseppe , Panzeri Elena , Rufini Alessandra , Testi Roberto , Martinuzzi Andrea
Published: March 2024

A drug repositioning effort supported the possible use of the anti-HIV drug etravirine as a treatment for Friedreich Ataxia (FRDA). Etravirine increases frataxin protein and corrects the biochemical defects in cells derived from FRDA patients. Because of these findings, and since etravirine displays a favorable safety profile, we conducted this pilot open-label phase 2 clinical trial assessing the safety and potential efficacy of etravirine in FRDA patients. Thirty-five patients were stratified into 3 severity groups and randomized to etravirine 200 mg/day or 400 mg/day. They were treated for 4 months. Efficacy endpoints were represented by changes in peak oxygen uptake and workload as measured by incremental exercise test, SARA score, cardiac measures, measures of QoL and disability. Data were collected 4 months before the start of the treatment (T-4), at the start (T0), at the end (T4) and 4 months after the termination of the treatment (T+4). Etravirine was well tolerated. Etravirine completely stopped the progression of the SARA score during the 4-months treatment period, compared to the 4 months pre and post treatment. It increased peak workload, while the improvement of peak oxygen uptake was not statistically significant. No changes in the cardiac measures were observed. Health and QoL measures showed a worsening at the suspension of the drug. In this open trial etravirine significantly improved neurological function and was generally safe and reasonably tolerated. This suggests that etravirine represents a potential therapeutic agent in FRDA deserving testing in a randomized placebo controlled clinical trial.
Spatial-Multitemporal Analysis of Heatwaves in Thailand: Discrepancies between In-Situ Air Temperature and Remote Sensing-Derived Land Surface Temperature
Authors: Chongtaku Thitimar , Taparugssanagorn Attaphongse , Miyazaki Hiroyuki , Tsusaka Takuji W
Published: March 2024

In light of the critical and emerging global challenge posed by the increasing frequency and severity of heatwaves in recent decades, this study demonstrates a practical and robust workflow that bridges the gap in understanding how the effective integration of remote sensing data with ground-based observations can facilitate a comprehensive assessment of spatiotemporal heatwave patterns and trends in the central region of Thailand. This research transcends traditional methods, utilizing air temperature (Tair) and satellite-derived land surface temperature (LST) data from 1981 to 2019. Results exhibit that an analysis of Tair indicates increasing daytime heatwaves in peri-urban areas, with significant trends in heatwave number (HWN), heatwave frequency (HWF), and heatwave duration (HWD), heatwave amplitude (HWA) rises in urban settings while nighttime heatwaves significantly intensify in rural locales. Notably, LST trends reveal varied patterns, with peri-urban areas showing marked daytime increases in heatwave magnitude (HWM), HWA, and HWF. Correlation analysis (p=0.05) highlights strong daytime associations between Tair and LST in rural (HWN, HWF, HWD, r>0.90) and peri-urban (HWM, HWA, r>0.65) regions. Overall, this study advances approaches to the adaptable measurement and spatial-temporal pattern of heatwave-related risk areas, providing insights for decision-makers to develop sustainable practices and strategies for climate change adaptation.
Antimicrobial resistance burden in India and Germany in 2022: A systematic analysis along with One Health perspective
Authors: K Gunjan , Pandey Ramendra Pati , K Himanshu , Mukerjee Riya , Chang Chung-Ming
Published: March 2024

Globally increasing antibiotic resistance has been connected to the use of antibiotics in medical, veterinary, and agricultural medicine, contributing to the burden of antibiotic resistance in Asia and Europe. The main objective of this study was to correlations of antimicrobial-resistant of various pathogens in three compartments: humans, animals and the environment in India and Germany. A systematic search was carried out in Medline via PubMed, Google Scholar, and science direct, including studies published in 2022. Out of 532 papers, 24 were considered for meta-analysis. This study reveals that in India, β-lactam is highly resistant in animals. Quinolone, on the other hand, was highly resistant in humans. Furthermore, in the environment and integrated studies, aminoglycosides and β-lactams is resistant. While in Germany, a high rate of AMR resistance in all three sectors was reported in β-lactam. However, E. coli was the most frequent pathogen in both countries and is highly resistant to β-lactam, followed by cephalosporin in all the compartments. Monitoring and evaluating antibiotic-sensitivity patterns and developing proper antibiotic regimens may lead to improved outcomes for inhibiting and controlling E. coli infections in various parts of the world.
Facile and economical preparation method of TiO2/activated carbon for photocatalytic degradation of methylene blue
Authors: Le Phuoc Huu , Vy Tran Thi Thuy , Thanh Vo Van , Hieu Duong Hoang , Tran Quang-Thinh , Nguyen Ngoc-Van Thi , Uyen Ngo Ngoc , Tram Nguyen Thi Thu , Toan Nguyen Chi , Xuan Ly Tho , Tuyen Le Thi Cam , Kien Nguyen Trung , Hu Yu-Min , Jian Sheng-Rui
Published: March 2024

Nanocomposites of TiO2 Degussa P25 nanoparticles/activated carbon (TiO2/AC ) were prepared at various mass ratios of (4:1), (3:2), (2:3), and (1:4) by a facile process. The effects of TiO2/AC mass ratios on the structural, morphological, and photocatalytic properties were systematically studied in comparison with bare TiO2 and bare AC. TiO2 nanoparticles exhibited dominant anatase and minor rutile phases, and a crystallite size of approximately 21 nm; while AC had XRD peaks of graphite and carbon, and a crystallite size of 49 nm. The composites exhibited tight decoration of TiO2 nanoparticles on micron-/submicron AC particles, and uniform TiO2/AC composites were obtained as evidenced by the uniform distribution of Ti, O, and C in an EDS mapping. Moreover, Raman spectra show the typical vibration modes of anatase TiO2 (e.g., E1g(1), B1g(1), Eg(3)) and carbon materials with D and G bands. The TiO2/AC with (4:1), (3:2), and (2:3) possessed higher reaction rate constants (k) in photocatalytic degradation of methylene blue (MB) than that of either TiO2 or AC. Among the investigated materials, TiO2/AC = 4:1 achieved the highest photocatalytic activity with a high k of 55.2×10-3 min-1 and an MB removal efficiency of 96.6% after 30 min treatment under UV-Vis irradiation (120 mW/cm2). The enhanced photocatalytic activity for TiO2/AC is due to the synergistic effect of the high adsorption capability of AC and the high photocatalytic activity of TiO2. Furthermore, TiO2/AC promotes the separation of photoexcited electron/hole (e-/h+) pairs to reduce their recombination rate and thus enhance photocatalytic activity. The optimal TiO2/AC composite in this study can be used for treating industrial or household wastewater with organic pollutants.
What do Stimulated Beta Cells have in Common with Cancer Cells?
Authors: Marhl Marko
Published: March 2024

This study investigates the metabolic parallels between stimulated pancreatic beta cells and cancer cells, emphasizing glucose and glutamine metabolism. Addressing the significant public health challenges of Type 2 Diabetes Mellitus (T2DM) and cancer, we aim to deepen understanding of the mechanisms driving insulin secretion and cellular proliferation. Our analysis of anaplerotic cycles and NADPH's role in biosynthesis elucidates their vital functions in both processes. Additionally, we find that both cell types share an antioxidative response mediated by the Nrf2 signaling pathway, glutathione synthesis, and UCP2 upregulation. Notably, UCP2 facilitates the transfer of C4 metabolites, enhancing reductive TCA cycle metabolism. We also uncover that hypoxic responses are transient in beta cells post-stimulation but persistent in cancer cells. By synthesizing these insights, our research suggests novel therapeutic targets for T2DM, highlighting the shared metabolic strategies of stimulated beta cells and cancer cells. This comparative analysis not only illuminates the metabolic complexity of these conditions but also emphasizes the crucial role of metabolic pathways in cell function and survival, offering fresh perspectives for tackling T2DM and cancer challenges.
Exploring the Nutritional Potential and Functionality of Hemp and Rapeseed Proteins: A Review on Unveiling Anti-nutritional Factors, Bioactive Compounds, and Functional Attributes
Authors: Axentii Marina , Codină Georgiana Gabriela
Published: March 2024

Plant-based proteins, like those derived from hemp and rapeseed can significantly contribute to a balanced diet and human daily nutritional requirements by providing essential nutrients such as protein, fiber, vitamins, minerals, and antioxidants. According to numerous recent research papers the consumption of plant-based proteins has been associated with numerous health benefits, including reduced risk of chronic diseases such as heart disease, diabetes, and certain cancers. Plant-based diets are often lower in saturated fat and cholesterol and higher in fiber and phytonutrients, which can support overall health and well-being. Present research investigates the nutritional attributes, functional properties, and potential food applications of hemp and rapeseed protein for a potential use in new food product development, with a certain focus on identifying anti-nutritional factors and bioactive compounds. Through comprehensive analysis, anti-nutritional factors and bioactive compounds were elucidated, shedding light on their impact on protein quality and digestibility. The study also delves into the functional properties of hemp and rapeseed protein, unveiling their versatility in various food applications. Insights from this research contribute to a deeper understanding of the nutritional value and functional potential of hemp and rapeseed protein, paving the way for their further utilization in innovative food products with enhanced nutritional value and notable health benefits.
A Review on the Feasibility and Efficacy of Home-Based Cognitive Remediation in People with Multiple Sclerosis
Authors: Boschetti Angela , Maida Elisabetta , Dini Michelangelo , Tacchini Marta , Gamberini Giulia , Comi Giancarlo , Leocani Letizia
Published: March 2024

Cognitive impairment affects 34-65% of People with Multiple Sclerosis (PwMS), significantly impacting their quality of life. Clinicians routinely address cognitive deficits with in-clinic neuro-behavioural interventions, but accessibility issues exist. Telerehabilitation is a promising solution that utilises digital tools for home-based cognitive remediation. This narrative review assessed the feasibility and efficacy of cognitive telerehabilitation in PwMS, identifying 13 relevant studies. Regarding the feasibility of cognitive telerehabilitation, evidence shows adherence rates are generally good, although, surprisingly, not all studies reported a measure of compliance with the cognitive training explored. Considering the efficacy of different rehabilitative techniques on cognitive performance of PwMS, findings are generally inconsistent, with only one study reporting consistently positive results. A range of methodological limitations are reported as potential factors contributing to the variability of results. Overcoming some of these issues will be key. Upcoming research is necessary to determine optimal intervention approaches, long-term effects of rehabilitation, and how to best integrate the use of telerehabilitation into routine clinical practice. By exploiting digital tools in the best way and addressing methodological concerns, home-based rehabilitation holds the potential for improving cognitive functions and enhancing the quality of life in PwMS.
Efficacy and Safety of Arterial Embolization for Scapular Metastases
Authors: Papalexis Nicolas , Peta Giuliano , Marinelli Alessandro , Errani Costantino , Quarchioni Simone , Di Carlo Maddalena , Miceli Marco , Facchini Giancarlo
Published: March 2024

Background: To investigate the safety and efficacy of palliative arterial embolization for metastases of the scapula.

Materials and Methods: We studied the files of the patients who underwent palliatrive arterial embolization for metastases of the scapula from January 2016 to January 2023, 15 patients (8 M, and 7 F) with a mean age of 62 years (SD 10.2) with two patients receiving a second procedure, for a total of 17 embolizations. Data on technical and clinical success, as well as changes in tumor size, were collected. All embolization-related complications were evaluated according to the CIRSE classification system for complications.

Results: The average follow-up was 18 months (Range 6-36 months). The main primary tumor were renal, lung and breast cancer. The primary arteries embolized were the circumflex scapular artery, the dorsal scapular artery, and the thoracoacromial trunk. A mixture of Glubran and Lipiodol in a 1:2 ratio was used for embolization, with an average of 1.1 mL (Range 0.5-1.5 mL) used per procedure. The efficacy of embolization was measured using the Visual Analogue Scale (VAS), with values recorded at baseline, at 1, 3, 6, and 12 months post-embolization, and at 6-month intervals after. Baseline VAS scores averaged 7.2 (SD 1.5), decreasing to 2.8 (SD 0.9) at one month. Progressive reduction was observed at 3, 6, and 12 months with scores of 2.3 (SD 0.8), 1.9 (SD 0.7), and 1.6 (SD 0.6) respectively. Metastatic tumor size was reduced from a mean of 192.2 cm3 (range 38.7 to 480.1 cm3) pre-embolization to a mean of 177.3 cm3 (range 37.2 to 455.5 cm3) at the 12-month follow-up (p
Mapping of Public Approach towards COVID-19 Vaccine for Preparedness and Resilience of Emerging Threats to Facilitate Cross-Country Systematic Roll-Out of Resources
Authors: Sarkar Jaimini , Sarkar Chiradeep
Published: March 2024

Background: Vaccine hesitancy was one of the problems India faced after the COVID-19 vaccine roll-out. Earlier studies carried out to understand the perception of people towards the vaccine were mainly based on online or offline community-based surveys. These studies do not help to understand the actions taken by people towards vaccination. Hence, this study has been designed to understand the exact behaviour of people toward the vaccine. Methods: The study population is divided into three age groups, 18+ years, 12-14 years, and 15-18 years. The data analysis has been done using cumulative coverage of vaccines in the said age groups. Results: The study shows a substantial population has missed second and booster doses of vaccine at the state, regional, and national levels in all three three-age groups. Even for the states that have shown the smallest number of people who missed their dose, their number is in the thousands. Conclusion: Further research is needed to know, in total population, how many people have not even taken a single dose of vaccine. Policy-level efforts are needed to cover the entire population of the country for at least a single dose and vulnerable population, not only for the primary series (1st and 2nd dose) but also for the booster dose of the COVID-19 vaccine.
Factors Influencing Artemisia Dubia Plant Biomass Productivity and Evaluation of Technological, Power and Environmental Parameters of Plant Utilization for Energy Conversion
Authors: Jasinskas Algirdas , Šiaudinis Gintaras , Karčauskienė Danutė , Bielska Renata-Marks , Marks Marek , Bielski Stanislaw , Mieldažys Ramūnas , Romaneckas Kęstutis , Šarauskis Egidijus
Published: March 2024

Abstract: Field studies with large-stemmed plants Artemisia dubia (wormwood) have been carried out at Vėžaičiai Branch LAMMC since 2018. According to three years of experimental results, annual dry matter (DM) yield varied from 7.94 to 10.14 t ha-1. Growing conditions, nitrogen ap-plication level and harvesting time had significant impacts on Artemisia dubia productivity. This article presents the results of research on preparation and use of Artemisia dubia biomass for en-ergy conversion and evaluation of technological-technical and environmental parameters of these plants utilization for solid biofuel. For experiments were used 6 variants of Artemisia dubia samples, which were grown in 2021: plants were cut three times and two fertilization options were used: (1) no fertilization and (2) fertilization with 180 kg ha-1 of nitrogen fertilizer. These harvested plants were chopped, milled and were pressed into the pellets. The physi-cal-mechanical characteristics (mоisture content, density and strength) of Artemisia dubia pellets were investigated. During this study, it was found that the density in dry mass (DM) of pellets ranged from 1119.86 to 1192.44 kg m-3. The pellet moisture content ranged from 8.80 to 10.49%. After testing of pellet strength, it was found that the pellets which were made from plant bio-mass PK-1-1, were the most resistant to compression, they withstood 560.36 N of pressure. Dry fuel lower heating value (LHV) of pellets was sufficiently high and was very close to pine saw-dust pellets, it varied from 17.46±0.25 MJ kg-1 to 18.14±0.28 MJ kg-1. The ash content of burned pellets ranged from 3.62±0.02% to 6.47±0.09%. Emissions of harmful pollutants – CO2, CO, NOx and unburnt hydrocarbons (CxHy) did not exceed the maximum permissible levels. Summariz-ing the results of investigated properties, cоmbustion and emissiоns of Artemisia dubia pellets, it can be concluded that this biofuel can be used for production of pressed biofuel and it is charac-terized by sufficient high quality, efficient combustion and permissible emissions to the envi-ronment.
In Vitro Glucose Uptake in Yeast Cell Facilitated by Abelmoschus esculentus L. (Okra Seed) for Management of Type 2 Diabetes
Authors: Aloysius Morris Terfa , Felekkis Kyriacos , Petrou Christos C. , Egwim Evans Chidi , Andreou Eleni
Published: March 2024

In vitro glucose uptake in yeast cell facilitated by Abelmoschus esculentus L. (okra seed) for management of type 2 diabetes was studied. Plant material was collected, identified, processed, and stored for further use. 80% methanol was employed for extraction and sonicated to release antidiabetic-bioactive component in solution and was filtered, concentrated, freeze-dried, and fractionated using standard techniques. Glucose uptake at an initial concentration of 5mM/L and 10mM/L by the crude extract was consistent to that of the known standard drug while at 25mM/L glucose concentration was equivalent with the crude extract. Also, at 0.625 mg/mL the linear equations, and R2 demonstrations that the crude extract was higher in dose predictability than the standard drug as presented by the equation; y = 35.754x - 57.822, and R² = 0.9502 (95%). The extract-fractions were employed to evaluate the ability of yeast cell line culture to take up glucose from the system through DPPH, FRAP, lipid peroxidation and anti-diabetes effect of extract-fraction assays. Extract-fractions were found to poses antioxidant activity high enough to inhibit stress-related diseases. The extract fractions were active as drug candidates both at low and high concentrations and were better compared with the standard drug and standard antioxidant was comparable. The high bioactive extract fractions require encapsulation with a nanoparticle as a drug candidate for type 2 diabetes patients. And an animal trial of the drug candidate may be necessary to monitor the in vivo performances of the extract fractions and subsequent human volunteered trial.
Bt-modified transgenic rice shifted the composition and diversity of rhizosphere microbiota
Authors: Huang Qi-Xing , Zhang Yu-Liang , Tan Yan-Hua , Kong Hua , Cao Yang , Wang Jun-Gang , Guo An-Ping , Yin Guohua
Published: March 2024

Plants significantly shape root-associated microbiota, making rhizosphere microbes useful environmental indicator organisms for safety assessment. Here, we report the pyrosequencing of the bacterial 16S ribosomal RNA in rhizosphere soil samples collected from transgenic cry1Ab/cry1Ac Bt rice Huahui No. 1 (GM crop) and its parental counterpart, Minghui63. We identified a total of 2,579 quantifiable bacterial operational taxonomic units (OTUs). Many treatment-enriched microbial OTUs were identified, including 14 NonGM-enriched OTUs and 10 GM-enriched OTUs. The rhizosphere microbiota communities were influenced more strongly by growth in the field than by rice varieties. Furthermore, Huahui No. 1 transgenic Bt rice had a greater impact on the rhizosphere bacterial communities than Minghui63. Early developmental stages of the transgenic Bt rice had a significant impact on many Bacillaceae communities. While soil chemical properties were not significantly altered by the presence of transgenic Bt rice, we found peak expression level of Bt proteins during the seedling stage, which may be an intriguing factor for bacterial diversity variations. Based on these findings, we conclude that transgenic Bt rice has a significant impact on root-associated bacteria. This information may be leveraged in future environmental safety assessments of transgenic Bt rice varieties.
Recent Advancement in Diagnosis of Biliary Tract Cancer through Pathological and Molecular Classifications
Authors: Lee Sang-Hoon , Song Si Young
Published: March 2024

Biliary tract cancers, including intrahepatic, perihilar, and distal cholangiocarcinomas, as well as gallbladder cancer, are a heterogeneous group of cancers with distinct molecular characteristics in each anatomic and pathological subtype. The pathological classification of BTC includes grossly classifiable growth patterns, such as mass-forming, periductal infiltrating, and intraductal growing. The small duct and large duct types of intrahepatic cholangiocarcinoma have been recently introduced in the WHO classification. Typical clinical presentations and various radiological, endoscopic, and molecular modalities for diagnosis are described in detail. To overcome the limitations of traditional tissue acquisition, new diagnostic modalities are being investigated. In fact, the treatment landscape is evolving rapidly owing to the emergence of distinct subgroups harboring unique molecular alterations with corresponding targeted therapies. In addition, we highlight the key points in the diagnostic process in real-world clinical practice for biliary tract cancer.
Meteorological and Agricultural Drought Risk Assessment via Kaplan-Meier Survivability Estimator
Authors: Cetinkaya Cem Polat , Gunacti Mert Can
Published: March 2024

Dry periods and drought are inherent natural occurrences. However, due to the increasing pressures of global warming and climate change, these events become more frequent and severe on a global scale. These phenomena can be traced with various indicators and related indices proposed by various scholars. In general, drought risk assessment is done by modelling these indicators and determining the drought occurrence probabilities. The proposed adaptation introduces the "Kaplan-Meier Estimator," a non-parametric statistic traditionally used in medical contexts to estimate survival functions from lifetime data. The study aims to repurpose this methodology to assess drought risk by treating past droughts as "events" and evaluating the Standardized Precipitation Index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) and map these results for a better understanding of the drought risks within larger spatial scales such as a river basin. The adapted method provides the probability of non-occurrence, with inverted results indicating the likelihood of drought occurrence. As a case study, the method is applied to SPI and SPEI values at different time steps (3, 6, and 12 months) across 27 meteorological stations in the Gediz River Basin, located in Western Turkey—a region anticipated to be profoundly affected by global climate change. The results are represented as the generated drought risk maps and curves, which indicate that (i) drought risks increase as the considered period extends, (ii) drought risks decrease as the utilized indicator timescales increase, (iii) locally plotted drought curves indicate higher drought risks as their initial slope get steeper. The method used enables the generation of historical evidence based spatially distributed drought risk maps which expose more vulnerable areas within the river basin.
Climate change may threaten the production of Bettelmatt cheese: environmental and regulatory challenges
Authors: Pennazio Rossana , Ruga Alessia , Ferrero Enrico
Published: March 2024

Bettelmatt cheese, a cherished Italian culinary gem hailing from the picturesque Val d'Ossola region, is deeply intertwined with its natural environment. This article explores the intricate relationship between the organoleptic attributes of Bettelmatt cheese and the challenges posed by climate change. The sensory qualities of this cheese, including its flavor profile, texture, and aroma, are profoundly influenced by the alpine pastures where the cows graze, the unique terroir, and the traditional production methods. However, as climate change continues to impact ecosystems and weather patterns, it raises questions about the resilience and adaptability of this traditional cheese. In addition to these challenges, the article would like to explore the complexities of regulation and protection of this cheese, crucial for food and gastronomic sciences.