bluuebunny/crossref_metadata_2025 huggingface dataset:
Racial and ethnic differences in healthcare access and utilization among U.S. adults with melanoma and keratinocyte carcinomas
Authors: Juarez Michelle C. , Shah Jill T. , Lee Nayoung , Stevenson Mary L. , Carucci John A. , Criscito Maressa C.
Published: September 2024

There is a paucity of information on racial and ethnic disparities relating to barriers to care in healthcare access and utilization in patients with cutaneous malignancies. We conducted a cross-sectional analysis of adults with melanoma, basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) in the National Institutes of Health (NIH) All of Us Research Program collected between May 2018 and July 2022. Participants included adults (aged 18 or older) with cutaneous malignancy who completed the Health Care Access and Utilization survey. We identified 5,817 adults who were diagnosed with BCC (67%), cSCC (28.9%), and melanoma (23.9%). Non-Hispanic Black (NHB) and Hispanic patients were more likely than non-Hispanic White (NHW) patients to delay a primary care visit due to cost (p = 0.005 and p = 0.015, respectively). NHB patients were also more likely to delay care due to lack of transportation (p < 0.001). NHB and Hispanic patients were more likely to place importance on seeing a provider from the same background (NHB p < 0.002; Hispanic p = 0.002) and also were more likely to report never being able to see such a provider (NHB p < 0.001; Hispanic p = 0.002). Medicaid/Medicare patients, non-college graduates, and those with lower incomes also faced increased barriers to care, including delays due to cost and transportation issues. People of color with cutaneous malignancies are more likely to delay care in seeing primary care providers due to cost or transportation issues. This study provides important insights on disproportionate healthcare usage among racial/ethnic groups that may help mitigate healthcare disparities
Dynamic stall on airfoils with leading-edge tubercles
Authors: Badia Pere Valls , Hickel Stefan , Scarano Fulvio , Li Mogeng
Published: September 2024

Leading-edge protuberances on airfoils have been shown to soften the onset of aerodynamic stall and to increase lift in the post-stall regime. The present study examines the effect of tubercles during dynamic stall. Pitching airfoils with tubercles of different amplitudes are studied by wind-tunnel experiments, where the three-dimensional time-resolved velocity field is determined using large-scale particle tracking velocimetry (PTV). Computational fluid dynamics (CFD) simulations are carried out that complement the experimental observations providing pressure distribution and aerodynamic forces. The dynamic stall is dominated by a vortex formed at the leading-edge; we characterize the vorticity, circulation , and advection path of this dynamic-stall vortex (DSV). The presence of the tubercles profoundly modifies the boundary layer from the leading-edge. The roll-up of the vorticity sheet is significantly delayed compared to a conventional airfoil, resulting in a weaker DSV. The vortex formation is shifted downstream, with the overall effect of a weaker and shorter lift overshoot, in turn enabling a quicker transition to deep stall. Regions of flow separation (stall cells) are visibly compartmentalized with a stable spacing of two tubercles wavelengths.
Urban Waste Fertilizer: Effects on Yield, Nutrient Dynamics, and PTE accumulation
Authors: Reimer Marie , Kurt Möller , Magid Jakob , Bruun Sander
Published: September 2024

Recycling nutrients contained in urban wastes to agriculture is essential in a circular society. This study simultaneously compares different recycled fertilizers (household waste compost, sewage sludge, human urine) with mineral fertilization and animal manures. Tested were their long-term effects on yield, nutrient budgets, potentially toxic element (PTE) accumulation, and nitrogen (N)/carbon cycle (a.o. N efficiency, N losses, soil carbon). Therefore, data from a long-term field trial and predictions from the soil-plant-atmosphere model DAISY were evaluated. Based on trial data, human urine performed similar to the mineral fertilization for yield, N efficiency (MEF = 81%), and nutrient budget, while sewage sludge and compost were more like animal manures with lower yields, N efficiencies (MEF 70% & 19% respectively) and higher nutrient imbalances, especially P and S surpluses. Compost and sewage sludge applications resulted in net PTE inputs. Yet, plant uptake and soil accumulation seemed neglectable. Model outputs predicted N losses of 34–55% of supplied N. Losses were highest for compost, followed by deep litter, manure, sewage sludge, human urine, mineral fertilization, and slurry. Nitrate leaching was the main loss pathway (14–41% of N input). Within the compost and straw-rich manure treatments, about 25% of applied N, were stored in the soil which was accompanied by an increase in soil carbon. The study suggests substitution of established fertilizers with recycled ones is feasible. Thereby each fertilizer has advantages and disadvantages, and thus should be utilized according to their strength or in mixtures.
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes
Authors: Li Jing , Li Siyu , Sun Qian , Li Ling , Zhang Yan , Hua Ziyu
Published: September 2024

Histone lactylation, a newly glycosis-related histone modification, plays a crucial role in the regulation of gene expression in various immune cells. However, the role of histone lactylation in astrocytes remains unclear. Here, this study showed that the H3K18 lactylation (H3K18la) levels were upregulated in primary astrocytes under unconjugated bilirubin (UCB) stimulation and hippocampus of bilirubin encephalopathy (BE) rats. Inhibition of glycolysis decreased H3K18la and attenuated pyroptosis both in vitro and in vivo. CUT& Tag and RNA-seq results revealed that H3K18la was enriched at the promoter of nucleotide-binding oligomerization domain 2 (NOD2) and promoted its transcription. Moreover, NOD2 boosted the activation of downstream mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways, which exacerbated the neuroinflammation of BE. Collectively, this study provides a novel understanding of epigenetic regulation in astrocytes, and interruption of the H3K18la/NOD2 axis may represent a novel therapeutic strategy for treating bilirubin encephalopathy.
A Unity Gain Cell-Based Current-Mode Universal Filter
Authors: Alpaslan Halil
Published: September 2024

This paper presents a practical implementation of a current-mode universal filter circuit using unity-gain cells, i.e., voltage and current followers. The presented universal filter uses four passive components and three unity-gain cells. Two grounded capacitors in the presented universal filter are appropriate for the integrated circuit manufacturing process. However, a resistive matching constraint is required for the high-pass filter, notch filter, and all-pass filter responses. 0.18 µm CMOS technology parameters and supply voltages of ± 1 V are used in the SPICE simulations. Several experimental studies verify the theory.
Hybrid random carrier-based noise suppression for automotive electronic water pumps
Authors: Ma Xipei , Feng Xiaodan , Fan Pingqing , Hu Xinyang , Li Yawei
Published: September 2024

To effectively mitigate the electromagnetic noise from automotive electronic water pump, this paper proposes and validates an electromagnetic noise suppression method based on hybrid random carrier technology. By leveraging the control model of the automotive electronic water pump and SVPWM harmonic theory, the paper analyzes the relationship between harmonics and electromagnetic noise in the control system. and studies the mechanism of random signal. Building upon control model and theory of vehicle electronic water pumps, the paper introduces randomized carrier wave mixing., Simulation results are then analyzed spectrally using the power spectrum transform method to verify the suppression ability of the carrier randomization technique on the higher harmonics. Furthermore, experimental verification is conducted through a noise characteristics experimental platform, affirming its correctness and effectiveness. This method significantly improves the high-frequency vibration and noise of the automotive electronic water pump without compromising the original control system or requiring additional hardware inputs. Therefore, the research findings of this paper offer a novel solution to reduce the electromagnetic noise from the automotive electronic water pump, holding significant practical application value for water pump motor development.
Generating Patient’s Electronic Health Records with Unseen Diseases Using Ontology-enhanced Generative Adversarial Networks
Authors: Sun Chang , Dumontier Michel
Published: September 2024

The generation of realistic synthetic personal health data such as those found in electronic health records may be useful for fundamental research, applied AI models, and to examine safeguards for data privacy. Generative Adversarial Networks (GANs) have been employed for this purpose, but their ability to generate data is largely constrained by the limitations of the data they are trained on. Consequently, these models fail to generate realistic synthetic data relevant to rare diseases or complex conditions. In this paper, we propose a novel generative framework (Onto-CGAN) that integrates knowledge drawn from disease ontologies, with conditional GAN models to to generate realistic synthetic health data for diseases not present in the training data. We examine the quality of the generated data through 1) distributions of single variables, 2) correlation coefficients of variable pairs, and 3) predictive model performance using four machine learn- ing models. Our results demonstrate that Onto-CGAN can generate unseen data with statistical characteristics comparable to real data, and significantly improve the training of machine learning models in classifying diseases absent from the training set. This work represents a first step towards generating complex synthetic health data with characteristics that closely mimic those of real data such that they can be used in situations where there is a paucity of available data, and may find applications for data augmentation, hypothesis generation, and pre-clinical validation of clinical models.
BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells
Authors: Toussaint Ashley , Singh Manohar , Wang Guoquiang , Driscoll Monica , Bhatt Vrushank , Ndong Jean De La Croix , Shuaib Sahil , Zoltowski Harrison , Gilleran John , Peng Youyi , Tsymbal Anastassiia , Jia Dongxuan , Roberge Jacques , Chiou Hellen , Guo Jessie Yanxiang , Herranz Daniel , Langenfeld John
Published: September 2024

Background
Bone morphogenetic protein (BMP) signaling cascade is a phylogenetically conserved stem cell regulator that is aberrantly expressed in non-small cell lung cancer (NSLC) and leukemias. BMP signaling negatively regulates mitochondrial bioenergetics in lung cancer cells. The impact of inhibiting BMP signaling on mitochondrial bioenergetics and the effect this has on the survival of NSLC and leukemia cells are not known.
Methods
Utilizing the BMP type 2 receptor (BMPR2) JL189, BMPR2 knockout (KO) in cancer cells, and BMP loss of function mutants in C elegans, we determined the effects of BMPR2 inhibition (BMPR2i) on TCA cycle metabolic intermediates, mitochondrial respiration, and the regulation of mitochondrial superoxide anion (SOA) and Ca++ levels. We also examined whether BMPR2i altered the threshold cancer therapeutics induce cell death in NSLC and leukemia cell lines. KO of the mitochondria uniporter (MCU) was used to determine the mechanism BMPR2i regulates the uptake of Ca++ into the mitochondria, mitochondrial bioenergetics, and cell death.
Results
BMPR2i increases mtCa++ levels and enhances mitochondrial bioenergetics in both NSLC and leukemia cell lines that is conserved in C elegans. BMPR2i induced increase in mtCa++ levels is regulated through the MCU, effecting mitochondria mass and cell survival. BMPR2i synergistically induced cell death when combined with BCL-2 inhibitors or microtubule targeting agents in both NSLC and leukemia cells. Cell death is caused by synergistic increase in mitochondrial ROS and Ca++ levels. BMPR2i enhances Ca++ uptake into the mitochondria induced by reactive oxygen species (ROS) produced by cancer therapeutics. Both acute myeloid leukemia (AML) and T-cell lymphoblastic leukemia cells lines were more responsive to the JL189 alone and when combined with venetoclax or navitoclax compared to NSLC.
RG flows in de Sitter: C-functions and sum rules
Authors: Loparco Manuel
Published: September 2024

We study the renormalization group flow of unitary Quantum Field Theories on two-dimensional de Sitter (dS) spacetime. We prove the existence of two functions of the radius of dS that interpolate between the central charges of the UV and IR fixed points of the flow when tuning the radius RR while keeping the mass scales fixed. The first is constructed from certain components of the two-point function of the stress tensor evaluated at antipodal separation. The second is the spectral weight of the stress tensor in the \Delta=2Δ=2 discrete series. This last fact implies that the stress tensor of any unitary QFT in dS_22 must interpolate between the vacuum and states in the \Delta=2Δ=2 discrete series irrep. We verify that the c-functions are monotonic for intermediate radii in the free massive boson and free massive fermion theories, but we lack a general proof of said monotonicity. We derive a variety of sum rules that relate the central charges and the c-functions to integrals of the two-point function of the trace of the stress tensor and to integrals of its spectral densities. The positivity of these formulas implies c^{UV}≥ c^{IR}cUV≥cIR. In the infinite radius limit the sum rules reduce to the well known formulas in flat space. Throughout the paper, we prove some general properties of the spectral decomposition of the stress tensor in dS_{d+1}d+1.
Deciphering the temporal dynamics of consumer decisions: the interplay of cognitive load and response correctness
Authors: Hojdik Vladimír , Štetka Peter , Grisáková Nora , Rybárová Daniela
Published: September 2024

This study delves into the impact of visual marketing stimuli on consumer response times, focusing on the complexity and subjectivity of the questions posed. Conducted in Slovakia, the research involved 40 participants (20 men and 20 women, aged 30 to 50 years), all holding university degrees in economics to ensure consistent decision-making experience. Participants were presented with visual stimuli representing four well-known FMCG brands. The stimuli included simple brand preference questions and complex evaluative judgments of offer efficiency. Response times were measured in milliseconds and analyzed using statistical methods, including the Mann-Whitney U test and one-way ANOVA. Results revealed that responses to simple stimuli averaged 1212 ms, while complex stimuli elicited slower responses, averaging 2504 ms. A significant difference was observed for “No” answers in the offer evaluation tasks, with correct “No” responses taking 3000 ms compared to 2297 ms for incorrect ones (p < 0.05), highlighting the cognitive load involved in accurate decision-making. These findings provide valuable insights into the cognitive processes driving consumer decision-making and contribute to the theoretical understanding of how question complexity and subjectivity influence response times.
AcknowledgmentThis paper was funded by research grant VEGA 1/0462/23 entitled “Circular economy in the context of societal demands and market limitations“ (100% share).
Impact of Climate Change Risk Management Strategies on Child Protection Systems in Zambia. A Case Study on Mansa District of Luapula Province
Authors: Phiri Field
Published: September 2024

Rural communities are subjected to impact of climate change and children are the most vulnerable. Adaptation to climate change poses, great challenge to Zambia, planners and decision makers need to appreciate application of strategic management. The study desired to establish the extent and impact of climate change on realization of children’s fundamental rights in rural agriculture dependent households, management and child protection systems in Zambia as well as to assess key factors of climate change and how it has contributed to inabilities of rural agricultural dependent households to fulfill fundamental rights of children. Contribute to the body of knowledge through proposing some measures that can address climate changes, with strategic management approach, community engagement, integrated with child rights approach. National Climate Change Policy sets two objectives with immediate relevance responding to climate change, public health and need strategic management, decisions: “To promote, strengthen implementation of adaptation and disaster risk reduction measures to reduce vulnerability to climate variability and change.” “To strengthen, institutional and human resource capacity, to effectively and efficiently address all aspects of climate change at, national, provincial, district and local levels.” There is need to strengthen, policies, promote application of prediction models and technologies to determine vulnerability sectors to climate change, support higher learning and research institutions on climate related research that supports child rights governance and protection. The study used combined methodology, action and explanatory. Much of the study methodology was explanatory in nature as it attempted to identify circumstances surrounding the extent and impact of climate change on realization of children’s fundamental rights in rural households. Key results includes Stakeholders, have not appreciated the application of strategic management in their planning and implementation of interventions on climate change with a child right’s lens. Climate change and environmental degradation are creating various crisis situations for children and rural households including social and economic crisis hence increasing vulnerability and poverty.
AVALIAÇÃO DA ADUBAÇÃO NITROGENADA E INFLUÊNCIA DE LÂMINAS DE IRRIGAÇÃO NAS CARACTERÍSTICAS AGRONÔMICAS E PRODUTIVIDADE DO MILHO SAFRINHA
Authors: Biancho Lucas Estevam , De Souza Raquel Nogueira , De Carvalho Jaqueline Bonfim , Donatoni Kaique Augusto Poltronieri , Souza Higor Nogueira de , Nakao Allan Hisashi
Published: September 2024

O milho é um cereal que necessita de grandes quantidades de nutrientes principalmente o nitrogênio. Assim, o trabalho objetivou avaliar as características agronômicas e produtividade do milho safrinha, com épocas de aplicações de nitrogênio e lâminas de água. Foi conduzido no Núcleo de Ensino, Pesquisa e Extensão (NEPE) / UNIFUNEC. Utilizou-se o delineamento experimental de blocos casualizados, com 4 repetições, em um esquema fatorial 4x4 totalizando 16 tratamentos. O primeiro fator avaliado foi diferentes épocas de aplicação da ureia (14, 7, 1 dias antes da aplicação da lâmina de água e 1 dia após aplicação da lâmina de água). O segundo fator avaliado consistiu em quatro diferentes lâminas de irrigação (5 mm, 10 mm, 15 mm e 20 mm). Avaliaram-se as características agronômicas (Altura da planta e inserção da primeira espiga; diâmetro do colmo; massa de 100 grãos), estande de plantas, diâmetro e comprimento de espiga, número de grãos e fileiras por espiga e produtividade. Os dados foram submetidos à ANOVA pelo teste de F, com médias comparadas pelo teste de Tukey a 5% de probabilidade. A aplicação de diferentes épocas de utilização de nitrogênio não alterou as características agronômicas, massa de cem grãos e produtividade do milho. Diferenças significativas foram observadas para as lâminas de água na variável produtividade, ajustando-se em modelo matemático do tipo quadrático. Assim, melhores resultados para a produtividade foram observados pela lâmina de 13,39 mm. Esses resultados sugerem a adoção da lâmina de água a partir da referida quantidade, podem promover incremento na produtividade.
Comparative analysis of decision tree, time series, and semi-distributed hydrological models for runoff prediction in snowmelt-influenced and human-activity-intensive basins: a case study of the Shiribeshi-Toshibetsu basin, Japan
Authors: Chen Yuechao , Liu Jiawen , Jiang Yaru , Gao Jiajia , Han Yaoyao
Published: September 2024

This study evaluates the performance of decision tree model (XGBoost), time series model (LSTM), and semi-distributed hydrological model (HBV) in simulating daily runoff in a watershed with significant snowmelt contributions and intensive human activity. Daily runoff data from the Shiribeshi-Toshibetsu basin in Japan, spanning the period from 1998 to 2015, were used for model training, with data from 2016 to 2019 for validation. Comparative analysis reveals that the XGBoost model outperforms the LSTM and HBV models,achieving a Nash–Sutcliffe Efficiency (NSE) of 0.94, compared to 0.85 and 0.84 for the LSTM and HBV models, respectively. Additionally, Partial Dependence Plots (PDPs) were utilized to investigate the nonlinear impacts of climatic factors on runoff, identifying precipitation, average temperature, and wind speed as the most significant drivers. Specifically, the relationship between temperature and runoff follows a unique pattern: runoff initially increases with rising temperatures, then decreases, and subsequently increases again. These findings underscore the robustness of decision tree models in handling complex hydrological data and highlight the importance of understanding the intricate interactions between climatic variables and runoff. This study provides scientific support for water resource management in similar watersheds under changing climatic conditions.
MODERN TRENDS IN IMPLEMENTING THE PLANETARY PROTECTION REQUIREMENTS IN THE PROCESS OF BUILDING SPACECRAFTS FOR SEARCHING POSSIBLE LIFE FORMS ON MARS
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Deshevaya Е.А. , Khamidullina N.М. ,   Lavochkin Scientific and Industrial Association, Khimki, Moscow region, Fialkina S.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Zakharenko D.V. ,   Lavochkin Scientific and Industrial Association, Khimki, Moscow region, Ustinov S.N. ,   Lavochkin Scientific and Industrial Association, Khimki, Moscow region, Orlov O.I. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Sychev V.N. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: September 2024

The paper reports the results of cooperation between the Institute of Biomedical Problems (IBMP / RAS) and Lavochkin Science and Production Association (Lavochkin NPA /ROSKOSMOS) in building the Mars landing modules. To comply with the mandatory planetary protection requirements, guidelines for specific stages of spacecraft assembly were developed and adopted. These include innovative procedures of cleaning, sterilization, etc. with account of specifics of each assembly and testing process. Data of the microbiological monitoring evidence for effectiveness of the procedures.
CONNECTOME AND MICROGRAVITY
Authors:   Bekhterev National Medical Research Center of Psychiatry and Neurology,  Ministry of Heath of the Russian Federation, St.-Petersburg, Galanin I.V. , Naryshkin A.G. ,   Bekhterev National Medical Research Center of Psychiatry and Neurology,  Ministry of Heath of the Russian Federation, St.-Petersburg, Skoromets Т.А. ,   Pavlov First St.-Petersburg State Medical University, Sarkisian А.М. ,   Bekhterev National Medical Research Center of Psychiatry and Neurology,  Ministry of Heath of the Russian Federation, St.-Petersburg, Orlov I.А. ,   Bekhterev National Medical Research Center of Psychiatry and Neurology,  Ministry of Heath of the Russian Federation, St.-Petersburg
Published: September 2024

The paper surveys the current views on formation, development and activity of the connectome under the influence of gravity. The neuroglia role and in formation and functioning of both the normal and disordered brain is considered. Connectome significance for the brain functioning is discussed. Analyzed is an input of the vestibular system, the key gravity-sensitive organ, in connectome formation and functioning. Changes in the connectome due to microgravity are described.
CHANGES IN ORAL MICROBIOCENOSIS UNDER THE INFLUENCE OF AUTO-PROBIOTICS BASED ON STREPTOCOCCUS SALIVARIUS IN THE CONDITIONS OF HYPOBARIA AND COLD STRESS
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Ilyin V.K. , Solovieva Z.O. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Nikonorov A.G. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Nosovsky A.M. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Rykova M.P. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Sheblaeva A.S. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Guizinger О.А. ,   Peoples' Friendship University of Russia named after Patrice Lumumba, Medical Institute, Moscow, Lovtsevich S.М. ,   Institute of Analytical Toxicology, Moscow, Sheblaev M.V. ,   Lomonosov Moscow State University, Kraeva L.А. ,   Saint-Petersburg Pasteur Institute
Published: September 2024

Benefits for oral microbiota from Streptococcus salivarius М18 as a BAS in the Dentoblis tablets (Serbia) and auto-probiotic S. salivarius strains, and their effectiveness in disbiosis prevention were compared in a 14-day hypobaria study. Dynamics of the qualitative and quantitative composition of the Streptococcus mutans pariodontal pathogenes, opportunistic oral pathogens Staphylococcus aureus, Fusobacterium spp., Candida spp., Prevotella spp., and protective oral microbiota Lactobacillus spp. was investigated before and after consumption of the commercial probiotics and auto-probiotic strains. Integral oral cavity investigation consisted of mass-spectrometry of the microbial markers and enzyme immunoassay (EIA). The best results (decreases in the quantities of S. mutans, S. aureus, Fusobacterium spp., Candida spp. and growth in Lactobacillus spp.) were gained by consumption of personified S. salivarius strains.
CORRELATION BETWEEN SOLAR ACTIVITY DYNAMICS AND BLOOD LEVELS OF ALKALINE PHOSPHATASE AND TOTAL LACTATE DEHYDROGENASE IN PATIENTS WITH HYPERTENSION AND VARIOUS PSYCHOSOMATIC STATUS
Authors:   Siberian State University of Geosystems and Technologies, Novosibirsk, Vasendin D.V. , Usenko G.A. ,   Novosibirsk State Medical University, Velichko A.Ja. ,   Novosibirsk City Clinical Hospital № 11, Velichko N.P. ,   Novosibirsk City Clinical Hospital № 11, Kolodin D.L. ,   Military Clinical Hospital № 425, Novosibirsk, Izotova T.A. ,   West-Siberian Department of Hydrometeorology and Environmental Monitoring, Novosibirsk
Published: September 2024

Purpose of the investigation is to establish a correlation between the solar activity and levels of alkaline phosphatase (AP) and total lactate dehydrogenase (LD) in male patients of different temperament in the course of antihypertensive therapy (AHT) using the psychosomatic approaches and empirical treatment. In the investigation performed in the period between 1995 and 2015, sick and healthy men were divided into equal groups with prevailing choleric, sanguine, phlegmatic and melancholic temperaments differing in the level of anxiety. Serum AP and TLD concentrations were correlated with mean annual values of the Wolf numbers, 10.7 cm solar flux, atmospheric pressure, γ-background and air temperature. Some groups were treated with AHT aimed at controlling the sympathetic nervous system in choleric and sanguine patients and the renin-angiotensin-aldosterone system in phlegmatic and melancholic patients, and some groups received empirical therapy. Levels of AP and TLD increased in line with the temperamental classification from the choleric to melancholic persons. High and moderate correlations were stated between the Wolf numbers and solar flux on one hand, and atmospheric pressure, γ-background and air temperature, on the other. Increase in AP and TLD correlated with growth of the solar activity. In contrast to the empirical therapy, АHТ produced a more distinct reduction of the enzymes keeping them essentially equal to concentrations in healthy persons of similar temperaments.
INVESTIGATION OF THE VESTIBULOPROTECTIVE PROPERTIES OF A NEW NICOTINIC ACID DERIVATIVE AND A NEW HETEROCYCLIC COMPOUND
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Yasnetsov Vik.V. , Ivanov Yu.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Karsanova S.K. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Yasnetsov V.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: September 2024

Experiments with rats demonstrated the apparent vestibuloprotective properties of new nicotinic acid derivative LKhT 20-19 and heterocyclic compound LKhT 3-21 at a dose of 50 mg/kg. In comparison to the control, they increased food intake following rotation in 1.9 and 2.5 times, respectively. LKhT 20-19 and LKhT 3-21 outperformed reference medicine mexicor (ethylmethylhydroxipyridine succinate) at the equal dose in 1.4 and 1.8 times, respectively. LKhT 3-21 outperformed LKhT 20-19 in 1.3 times.
PENGARUH JOB EMBEDDEDNESS TERHADAP ORGANIZATIONAL CITIZENSHIP BEHAVIOR
Authors: Maharani Agnesia , Satria Dias
Published: September 2024

This research investigates the impact of job embeddedness on organizational citizenship behavior among workers in Banyuwangi Regency in 2024. Job embeddedness includes employees' connections with the organization, value congruence, and personal sacrifices to remain employed. Organizational citizenship behavior refers to individual contributions that exceed formal job requirements, such as helping colleagues and participating in organizational activities. The research method used is quantitative with a survey approach. Data were collected from a sample of workers in Banyuwangi Regency and analyzed using statistical techniques. The results showed that job embeddedness significantly influences organizational citizenship behavior. Employees who feel attached to their jobs tend to be more active and contribute more to organizational activities. The implications of this research highlight the importance for organizational management to enhance job embeddedness to promote positive organizational citizenship behavior. Organizations can achieve this by creating a supportive work environment, providing training, and appropriate incentives.
Position-dependent mass Schrodinger equation for the q-deformed Woods-Saxson plus hyperbolic tangent potential
Authors:   Department of Physics, Mutah University, Al-Karak, Jordan, Jaradat Emad , Tarawneh Saja ,   Department of Physics, Mutah University, Al-Karak, Jordan, Aloqali Amer ,   Department of Physics, Mutah University, Al-Karak, Jordan, Ajoor Marwan ,   Department of Physics, Mutah University, Al-Karak, Jordan, Hijjawi Raed ,   Department of Physics, Mutah University, Al-Karak, Jordan, Jaradat Omar ,   Department of Mathematics, Mutah University, Al-Karak, Jordan
Published: September 2024

In this work, we propose a new potential called the "q-deformed Woods-Saxon plus hyperbolic tangent potential." We derive the generalized Schrödinger equation for quantum mechanical systems with position-dependent masses under these potentials using the Nikiforov-Uvarov method, with the mass relationship defined as m(x)=m_1⁄((1+qe^(-2λx))). The solutions to this equation, expressed in terms of hypergeometric functions and Jacobi polynomials, offer insights into the quantum behavior of particles. The energy eigenvalues depend on system parameters such as the deformation parameter q, potential parameters, and quantum numbers. We analyzed the effect of the deformation parameter q numerically and visually using different values of these parameters.
Entrepreneurship and its Implications for Standards of Living in Cameroon
Authors: Paul Akumbom,  , Randolph Kafain
Published: September 2024

The study intended in determining the effect of entrepreneurship on standards of living in Cameroon. Thestudy made use of secondary data over a period of 42 years and the data was obtained from the World Bankdatabase. The researcher applied the causal research design and used both descriptive and inferentialstatistics to analyse the data collected. Results from the ARDLregression revealed that there exist a positivesignificant effect of entrepreneurship at the primary sector on standards of living in Cameroon in the shortrun and an insignificant effect of entrepreneurship on standards of living in the long run. Entrepreneurship atthe secondary sector was found to exert a negative insignificant effect on standards of living Cameroon inthe short and a positive insignificant effect in the long run in Cameroon. The coefficient for entrepreneurshipin the tertiary sector was positive and significant in both the short and long term, with a significance level of5% in the short term and insignificance in the long term. Secondary education was determined to have anegligible beneficial impact on long-term standards of living in Cameroon, and a negligible detrimentalimpact in the near term. Further findings indicate that higher education has a negligible detrimental impacton long-term standards of living in Cameroon, whereas it has a negligible beneficial impact. The inflationrate, as assessed by the consumer price index, had a positive coefficient in the long term and was statisticallysignificant at a 5% level of significance. Additionally, in the short term, it had a significant impact on thestandards of living in Cameroon at a 1% level of significance.
Guía conceptual para el establecimiento del marañón en la altillanura plana de la Orinoquia
Authors: Mateus Cagua Diana Mayerly , Parrado Moreno Carmen Alicia , Camacho Delgado Hernán Oswaldo , Sandoval Contreras Héctor Augustos , Gallo Gordillo Oscar Javier , Pulido Castro Sandra Xiomara , Bernal Riobo Jaime Humberto
Published: September 2024

Las prácticas de gestión de los agroecosistemas son determinantes en el proceso de transformación de paisajes productivos hacia la sostenibilidad. En cultivos permanentes como el marañón, la planificación predial y productiva es fundamental para lograr este fin. Este proceso requiere una sólida base conceptual que garantice la toma de decisiones informada y eficaz para el establecimiento de cultivos de marañón. La identificación de las restricciones edáficas, climáticas y ambientales del cultivo de marañón, para una correcta selección y establecimiento, contribuirá a alcanzar el potencial productivo y lograr un buen rendimiento de los clones entregados por AGROSAVIA en el año 2013. Este documento presenta aspectos claves, desde el punto de vista conceptual, que deben considerarse en las fases de planeación y establecimiento, como herramienta para tomar decisiones informadas y oportunas. Esto favorecerá la consolidación de su cadena de valor, el escalamiento y consolidación de agroecosistemas de marañón bajos en carbono y nuevas oportunidades de negocios basados en los servicios
Mental health–specific knowledge in participants with and without sleep or social competence deficits: Factors influencing knowledge gain through psychoeducation in e-mental health interventions (Preprint)
Authors: Borsutzky Swantje , Gehlenborg Josefine , Rolvien Lara , Moritz Steffen
Published: September 2024

BACKGROUND

One in eight people worldwide experiences mental health disorders, with depression and anxiety being the most common. E-mental health programs are gaining momentum in modern mental health care.

OBJECTIVE

The study aimed to investigate factors influencing knowledge gain in low-threshold e-mental health programs focusing on sleep and social competence. Specifically, it examined how different media formats (text vs. video), topics, and presentation sequences (e.g., video-text vs. text-text) affected knowledge gain. Additionally, it assessed whether participants with deficits in sleep and/or social competence had knowledge gaps that could be addressed through targeted psychoeducation. The study also explored if knowledge gain resulted in increased certainty in correct judgments and reduced overconfidence in incorrect ones.

METHODS

An exploratory online study with 158 participants classified them into groups based on self-reported deficits in sleep/social competence. Participants initially took a knowledge test on sleep and social competence, including questions about their certainty in their answers. They were randomized into nine conditions, receiving video- or text-based information on sleep and social competence, with a sequence of media presentation varying by group. After the intervention, participants retook the knowledge test to measure knowledge gain.

RESULTS

No significant differences were found among the nine conditions, indicating that the medium (video vs. text), topic (sleep, social competence), or sequence had minimal influence on knowledge gain. Participants with self-reported deficits showed lower prior knowledge and greater knowledge gain after the psychoeducation compared to those without deficits. Knowledge gain was associated with increased certainty in correct responses, while confidence in incorrect responses remained unchanged.

CONCLUSIONS

Overall, individuals with self-reported sleep or social competence deficits can enhance their knowledge through psychoeducation, regardless of the type and order of the media used.

CLINICALTRIAL

Ethical approval was obtained from the local ethics committee of the University Medical Center Hamburg-Eppendorf (Germany, approval number: LPEK-0399),
The Use of Stance Markers in Chinese and International Journal Abstracts in Aerospace
Authors: XU Zhixin , WANG Pei
Published: September 2024

Stance in academic discourse refers to the writer-oriented approach to interact with readers by commenting on the credibility of propositions, expressing their own attitudes or mentioning themselves. This study compares and analyzes the overall distribution and differences of the use of stance markers in Chinese and international journal abstracts. The corpus includes 200 journal abstracts from the both top 10 Chinese and international academic journals of aerospace discipline from 2018 to 2022. The results show that Chinese and international journal abstracts frequently use stance markers to express author’s attitudes and the following pattern appears in both journals according to the frequency of use, that is, epistemic stance markers> attitude markers > self-mention. Meanwhile, Chinese and international journals differ significantly in the use of approximators, shields, affect markers, first person self-mention and third person self-mention. International journals also seem to adopt more hedges than boosters, while Chinese journals adopt more boosters than hedges. A comparative analysis of stance markers could provide some reference for Chinese authors in writing academic abstracts.
VITAMIN D DEFICIENCY IN PREGNANCY: EFFECT ON MATERNAL AND FETAL OUTCOME
Authors: USHA KUMARI  , RAJ KISHOR SHARMA  , ARCHANA SINHA
Published: September 2024

Objective: Vitamin D deficiency (VDD) during pregnancy is known to affect the neonatal morbidity and mortality. This study was conducted in pregnant women with the aim of assessing the prevalence of VDD in pregnant women and its effect on expecting mother and newborn.
Methods: This was a cross-sectional study done over a period of 2 years. 25(OH)D3 level was tested by Chemiluminescent Immunoassay in clinical biochemistry laboratory. Subjects were classified into Vitamin D-deficient, insufficient, and sufficient group.
Results: Mean level of Vitamin D in the study population was 21.82±12.95. The level of Vitamin D was found to be sufficient only in 28% (28/100) of subjects. A significant correlation was observed between newborn birth weight and serum Vitamin D level of the mother. Appearance, pulse, grimace, activity, and respiration (APGAR) score was moderately and severely depressed in 17% and 3% of babies, respectively. Pre-eclampsia was observed in 8% (8/100) of the subjects. A significant correlation was observed between the occurrence of pre-eclampsia and maternal Vitamin D. APGAR score was found to be significantly associated with serum Vitamin D.
Conclusion: There is a high prevalence of VDD in pregnant women. VDD in pregnancy is associated with several complications to the expectant mother as well as the fetus. Complications such as pre-eclampsia, low birth weight (LBW) babies, and low APGAR score were observed in the present study. There is a need of extensive clinical research on the impact of VDD in pregnancy on mother and fetal health.
ARTE-EDUCAÇÃO MODERNA E PÓS-MODERNA: COEXISTÊNCIAS NA PRÁTICA PEDAGÓGICA
Authors: Gusmão Roney , Cruz Ana Larissa
Published: September 2024

Interessa-nos observar como o tempo pós-moderno aportou na prática pedagógica, de modo a criar novas demandas para a arte-educação. Para tal, entrevistamos professores e alunos, tendo em vista observar como a concatenação de temporalidades no presente lhes serve para formular discursos e orientar práticas. Na pesquisa empírica observamos que diferentes referenciais sobre o papel das artes na escola coexistem, seja motivando abordagens mais revolucionárias, seja servindo para justificar a replicação de estratégias pedagógicas herdadas da modernidade.
La administración de justicia de menores en México. La reforma del artículo 18 de la Constitución Política de los Estados Unidos Mexicanos
Authors: González Ibarra Juan de Dios , Reyes Barragán Ladislao Adrián
Published: September 2024

Número 118Enero - Abril 2007ISSN 0041 8633 LA ADMINISTRACIÓN DE JUSTICIA DE MENORES EN MÉXICO. LA REFORMA DEL ARTÍCULO 18 DE LA CONSTITUCIÓN POLÍTICA DE LOS ESTADOS UNIDOS MEXICANOS Juan de Dios GONZÁLEZ IBARRA*Ladislao Adrián REYES BARRAGÁN** Las últimas reformas que ha tenido la regulación sobre menores infractores en México han abierto un terreno fértil para la discusión jurídica, pues existen varias posturas al respecto. Los autores de este artículo nos muestran la evolución del artículo 18 constitucional encargado de la regulación en la administración de justicia para menores, y explican la interacción que habrá de darse entre el Poder Judicial de la Federación y la Secretaría de Educación Pública, pues en concordancia con los lineamientos internacionales el menor no es un delincuente sino un infractor que requiere de supervisión y educación. Es decir, requiere de un tratamiento de tipo preventivo y formador, más que de tipo correccional, lo cual representa un gran avance en nuestro sistema de impartición de justicia. Palabras clave: menores, sistema de justicia, reforma constitucional. * Profesor e investigador de la UAEM. Tutor en la UNAM. jdgiba@correo.xoc.uam.mx. ** Profesor e investigador de la UAEM. ladislao.reyes@buzon.uaem.mx o lreyes@correo.ajusco.upn.mx. * Nota: Debido que la traducción es automática podrá ser inexacta o contener errores.
Concepto de democracia y sistema de gobierno en América Latina
Authors: Carpizo Jorge
Published: September 2024

Número 119Mayo - Agosto 2007ISSN 0041 8633 CONCEPTO DE DEMOCRACIA Y SISTEMA DE GOBIERNO EN AMÉRICA LATINA Jorge CARPIZO* En el presente artículo, el autor comenta y examina los distintos aspectos vinculados con el debate sobre las ventajas y desventajas de dos distintas formas de sistema de gobierno: presidencialismo y parlamentarismo. En primer lugar, realiza el autor una aproximación a los puntos centrales del debate, que, como describe en su ensayo, ha ocupado y preocupado en las últimas décadas a América Latina. Posteriormente, examina las críticas que se han hecho al sistema presidencial en la referida región, para después centrar su atención en las razones de por qué el sistema presidencial, cuando menos por ahora, debiera ser conservado en dicha región, si bien con reformas que lo racionalicen y lo equilibren. El autor lleva la discusión al terreno de la democracia, en virtud del razonamiento según el cual, la guía para cualquier intento de reforma o renovación constitucional de las instituciones del Estado debe ser la conservación y el fortalecimiento de la estabilidad democrática de las naciones latinoamericanas. Palabras clave: Formas de gobierno, sistema presidencial, sistema parlamentario, democracia. * Investigador emérito y ex rector de la Universidad Nacional Autónoma de México. Presidente del Instituto Iberoamericano de Derecho Constitucional. Agradezco a los investigadores y colegas Diego Valadés y Edgar Corzo la lectura de este ensayo y sus importantes sugerencias. Cualquier error que el mismo pueda contener es responsabilidad exclusiva del autor. Asimismo, agradezco al doctorante José Luis Garza Rodríguez la colaboración bibliográfica que me prestó, a la maestra Eugenia Lizalde la revisión final del manuscrito, y a mi secretaria, la señora Isabel Cacho, la transcripción definitiva del artículo. * Nota: Debido que la traducción es automática podrá ser inexacta o contener errores.
Entre la jurisdicción, la competencia y el forum non conveniens
Authors: Gabuardi Carlos A.
Published: September 2024

Número 121Enero - Abril 2008ISSN 0041 8633 ENTRE LA JURISDICCIÓN, LA COMPETENCIA Y EL FORUM NON CONVENIENS* Carlos A. GABUARDI** Este trabajo se centra en identificar, explicar y distinguir los conceptos de jurisdicción, competencia y forum non conveniens. El investigador explora la correlación entre la asunción de jurisdicción y la ejecución de sentencias extranjeras en los tres países de América del Norte. También expresa su opinión en cuanto al desentendimiento de los conceptos de competencia y jurisdicción en el Common Law y en la tradición romano-germánica, como uno de los puntos cruciales para impedir el buen logro de la fallida Convención de La Haya sobre Ejecución de Sentencias Extranjeras. Finalmente, aborda la conveniencia de adoptar la institución del fórum non conveniens en los países de tradición romano-germánica. Palabras clave: jurisdicción, competencia, forum non conveniens, derecho comparado, ejecución de sentencias extranjeras, litigio internacional. * Artículo recibido el 31 de mayo de 2007 y aceptado el 6 de agosto de 2007. ** Profesor de derecho y director de la Cátedra en Derecho "Eduardo A. Elizondo" en el Instituto Tecnológico y de Estudios Superiores de Monterrey. * Nota: Debido que la traducción es automática podrá ser inexacta o contener errores.