bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal histopathological predictors of end-stage kidney disease in ANCA-associated vasculitis with glomerulonephritis: a single-centre study in Korea
Authors: Choi Sung-Eun , Lee Soo Bin , Pyo Jung Yoon , Ahn Sung Soo , Song Jason Jungsik , Park Yong-Beom , Lim Beom Jin , Lee Sang-Won
Published: September 2023

This study investigated whether histopathological classification and histologic lesion scores could significantly and independently predict the progression to end-stage kidney disease (ESKD) in Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis-glomerulonephritis (AAV-GN). This study included 113 patients with AAV-GN confirmed by kidney biopsy. The glomerular, tubulointerstitial, and vascular lesions were systematically assessed using a scoring system. The scoring system was adopted from the Banff scoring system but also the Oxford study and the revision of the ISN/RPS. For comparison, the scores were classified into two groups; the low, and the high, and the difference was investigated between ESKD and non-ESKD groups using Cox proportional analysis. At diagnosis, the median age was 59.0 years and 33.6% were males. Of 113 patients, 44.2% had ESKD progression during follow-up. There were significant differences in several kidney-, inflammation-, and AAV-pathogenesis-related variables between AAV-GN patients with ESKD and those without. The sclerotic class exhibited the worst renal prognosis among the four histopathological classes. Among histopathological features, high interstitial fibrosis, tubular atrophy and global glomerulitis scores were significantly associated with ESKD progression. Whereas multivariable Cox analysis revealed only a high global glomerulitis score which means global endocapillary hypercellularity in a larger number of glomeruli is an independent predictor of ESKD progression. Moreover, among clinical and histopathological features, a high global glomerulitis score could also predict ESKD progression in addition to serum blood urea nitrogen and creatinine. This study demonstrated the worst renal prognosis for the sclerotic class and first discovered that a high global glomerulitis score was an independent predictor of ESKD in patients with AAV-GN.
Randomized phase-III study of low-dose cytarabine and etoposide + /− all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia
Authors: Schlenk R. F. , Weber D. , Krzykalla J. , Kindler T. , Wulf G. , Hertenstein B. , Salih H. R. , Südhoff T. , Krauter J. , Martens U. , Wessendorf S. , Runde V. , Tischler H. J. , Bentz M. , Koller E. , Heuser M. , Thol F. , Benner A. , Ganser A. , Döhner K. , Döhner H.
Published: September 2023

The aim of this randomized clinical trial was to evaluate the impact of all-trans retinoic acid (ATRA) in combination with non-intensive chemotherapy in older unfit patients (> 60 years) with newly diagnosed NPM1-mutated acute myeloid leukemia. Patients were randomized (1:1) to low-dose chemotherapy with or without open-label ATRA 45 mg/m2, days 8–28; the dose of ATRA was reduced to 45 mg/m2, days 8–10 and 15 mg/m2, days 11–28 after 75 patients due to toxicity. Up to 6 cycles of cytarabine 20 mg/day s.c., bid, days 1–7 and etoposide 100 mg/day, p.o. or i.v., days 1–3 with (ATRA) or without ATRA (CONTROL) were intended. The primary endpoint was overall survival (OS). Between May 2011 and September 2016, 144 patients (median age, 77 years; range, 64–92 years) were randomized (72, CONTROL; 72, ATRA). Baseline characteristics were balanced between the two study arms. The median number of treatment cycles was 2 in ATRA and 2.5 in CONTROL. OS was significantly shorter in the ATRA compared to the CONTROL arm (p = 0.023; median OS: 5 months versus 9.2 months, 2-years OS rate: 7% versus 10%, respectively). Rates of CR/CRi were not different between treatment arms; infections were more common in ATRA beyond treatment cycle one. The addition of ATRA to low-dose cytarabine plus etoposide in an older, unfit patient population was not beneficial, but rather led to an inferior outcome.

The clinical trial is registered at clinicaltrialsregister.eu (EudraCT Number: 2010-023409-37, first posted 14/12/2010).
TOF-SIMS study of latent fingerprints on challenging substrates with the aid of transfer films
Authors: Liu Zhaolun , Li Wenjie , Wu Yin , Man Hanze , Zhao Ya-Bin , Li Zhanping
Published: September 2023

This work provides a new approach for sample introduction in instrumental analysis, enabling TOF-SIMS to be applied in more scenarios.
Earth's field NMR relaxation of pre-polarised water protons for real-time detection of free-radical formation
Authors: Topor Alexandru , Voda Mihai A. , Vasos Paul R.
Published: September 2023

Real-time imaging of free-radical formation by Earth-field nuclear magnetic resonance is proposed for applications in physical chemistry, biochemistry, and radiobiology.
Ca substitution improves the catalytic activity of perovskite LaCoO3 toward toluene: comprehension of electronic structure alteration
Authors: Chen Hanlin , Wei Gaoling , You Zijuan , Liang Xiaoliang , Liu Peng , Yang Yiping , Tan Fuding , Wang Suhua , Xing Jieqi , Suib Steven L.
Published: September 2023

The catalytic activity of LaCoO3 perovskite towards toluene oxidation is enhanced by Ca substitution, which is determined by the O p band center relative to the EF.
Realization of nitroaromatic chromophores with intense two-photon brightness
Authors: Sadowski Bartłomiej , Kaliszewska Marzena , Clermont Guillaume , Poronik Yevgen M. , Blanchard-Desce Mireille , Piątkowski Piotr , Gryko Daniel T.
Published: September 2023

Effective manipulation of electronic effects within substituted nitroaromatics based on the dipyrrolonaphthyridinedione (DPND) core leads to fluorescent dyes with enhanced emission intensity as well as two-photon response.
Enhanced electrochemiluminescence imaging of single cell membrane proteins based on Co3O4 nanozyme catalysis
Authors: Zhang Jingjing , Hao Lin , Chao Jie , Wang Lianhui , Su Shao
Published: September 2023

The development of enhanced strategies with excellent biocompatibility is critical for electrochemiluminescence (ECL) imaging of single cells.
Exploring the impact of sodium salts on hydrotropic solubilization
Authors: Benfica Jordana , Martins Afonso C. , Peréz-Sanchéz Germán , Schaeffer Nicolas , Coutinho João A. P.
Published: September 2023

The influence of salts, in the presence of an ionic liquid, on the aqueous solubility of syringic acid was assessed by determining the respective contribution of pH and hydrotropy.
The adsorption of nitrobenzene over an alumina-supported palladium catalyst: an infrared spectroscopic study
Authors: McCullagh Annelouise M. , Gibson Emma K. , Parker Stewart F. , Refson Keith , Lennon David
Published: September 2023

The adsorption geometry of nitrobenzene over a 5 wt% Pd/Al2O3 catalyst is investigated by a combination of infrared spectroscopy and DFT calculations.
Fish scale derived hydroxyapatite incorporated 3D printed PLA scaffold for bone tissue engineering
Authors: Thomas N. G. , Dalvi Y. B. , Fijol N , Shilpa J. , Unni Rekha , Binsi P. K. , Varghese M. G. , R Reshmy. , Mathew A. P. , Anil Sukumaran
Published: September 2023

Discover the innovative approach of utilizing fish scales to derive hydroxyapatite, coupled with a 3D printed PLA scaffold, paving a novel avenue for bone tissue engineering.
Efficient H2 adsorption using a bimetallic Ni–Zn zeolite imidazole skeleton
Authors: Peng Xiaoqian , Zhang Jing , Zhang Xu , Liu Xiaochan , Huang Zhiqiang , Li Haibo , Yi Xibin
Published: September 2023

Ni–Zn bimetallic MOFs with a high micropore rate provide multiple active sites for H2 adsorption (1.35 wt%, 77 K, 1 bar).
Micro-encapsulation of rare earth metal ion-doped magnesia-based alginate/pectin hybrid polymeric composites for defluoridation of water
Authors: Jeyaseelan Antonysamy , Viswanathan Natrayasamy , Aswin Kumar Ilango , Hatshan Mohammad Rafe
Published: September 2023

Fluorosis is a health problem that affects many people worldwide.
Metal–organic framework for high-performance catalyst layers in proton-exchange membrane fuel cells
Authors: Choi Inyoung , Lim Jinhyuk , Reis Roberto dos , Kim Eunji , Lim Soo Yeon , Dravid Vinayak P. , Kim Heejin , Oh Keun-Hwan , Nam Kwan Woo
Published: September 2023

Metal–organic framework, a water-rich additive in the MEA, enhances the power performance of PEMFCs at low RH by promoting water back-diffusion.
The use of phytohormones to increase the efficiency of potato propagation in nodal cuts culture
Authors: Stupko Valentina Yu. , Lugovtsova Svetlana Yu.
Published: September 2023

Micropropagation of potato in vitro by periodic cutting of plants and passaging them to new nutrient media is the most common approach to obtaining large volumes of planting material in mini-tuber production systems. The article summarizes research data on the effect of gibberellic acid, auxins, and cytokinins on the rate of plant growth and internode formation of potato microplants in vitro. According to the results published in the scientific literature, the greatest efficiency in the process of series cutting of plants can be achieved by using media with a predominance of gibberellic acid in combination with auxins. The use of cytokinins is not relevant within this technology framework.
Features of stone fruit crop pests development in extreme conditions of Karakalpakstan
Authors: Toreniyazov Tilewmurat E.
Published: September 2023

The article presents the results of studying the species composition and bioecological features of the development and dynamics of the number of pest species living on stone fruit crop biocenosis in the conditions of Karakalpakstan. The features of species development living on apricot, peach depending on the elements of biotic and abiotic factors are determined. It was revealed that in this agrobiocenosis, individuals emerge from overwintered eggs of mealy plum aphids, peach aphids, and large peach aphids in March and multiply massively until July, causing damage to crops. To prevent these losses, chemical treatments against the first and second aphid generation are recommended, which provide full plant protection.
To the biology of the European lantern fly, Dictyophara europaea, in the Middle Volga region of Russia
Authors: Bogoutdinov Damir , Mityushev Ilya , Girsova Natalya , Kastalyeva Tatyana , Chigina Nelly
Published: September 2023

The European lantern fly, Dictyophara europaea (Linnaeus, 1767) (Insecta: Hemiptera: Dictyopharidae) is an abundant species in Eurasia and North Africa, inhabiting the grassy vegetation of open spaces, and does not have the status of a pest of agricultural plants. The purpose of this study was to assess the relative prevalence of planthopper under conditions of eco- and agroecosystems on herbaceous and woody plants in the Samara region of Russia for the period 1992-2016. Along with natural vegetation, D. europaea was also registered on potatoes, barley and perennial fodder grasses, as well as on cherry, plum and black poplar. The feeding of D. europaea was observed on potatoes, watermelon, pumpkin, alfalfa, as well as on wild plants: steppe sage, tuberous rank, chicory, and on woody plants: common lilac and bird cherry. It was found that the abundance of D. europaea increased by 2.2 times in the 21st century compared to the 20th century. It is reported that under conditions of the Samara region of Russia, D. europaea can be a potential vector of phytoplasma belonging to the pigeon pea witches’-broom group – 16SrIX, which may have phytosanitary significance for cultivated plants.
Experimental bases of crop productivity depending on agrotechnical conditions
Authors: Mazirov M.A. , Ragimov A.O. , Shchukin I.M. , Shenterova E.M. , Malakhova S.D. , Shitikova A.V.
Published: September 2023

As a result of the research, experimental data were obtained on the yield of cultivated crops depending on the type of crop rotation, fertilizer and treatment systems, and their mutual effect on improving ALSZ on the soils of the Vladimir high plain. The main types of fertilizer systems and their effect on the yield of grasses in crop rotation are described. Experimental data have been used to study the effect of various fertilizer systems on productivity, density, botanical composition, and yield of perennial grasses. It is proved that the yield parameters directly depend on the specific tillage system. The effect of fertilizer doses on the yield and productivity of perennial grasses for 2 years of use was revealed.
Theoretical, methodological, and breeding results of the DIAS program in increasing grain production using the example of creation of a soft spring wheat variety - Kazakhstanskaya rannespelaya (origin, characteristics, economic value)
Authors: Novokhatin V.V. , Dragavtsev V.A.
Published: September 2023

The selection of parental pairs is carried out considering their genealogical trees and the dynamics of the lim factors of the environment, in the creation area, with further hybridization, and subsequent multiple re-sowing of the population. The Kazakhstanskaya rannespelaya variety was created by selection from the F5 hybrid combination of Novosibirskaya 67 × Omskaya 9, the Interdepartmental program DIAS. The breeding record of Novosibirskaya 67 consists of 9 and Omskaya 9 – of 37 varieties, of which 19 are of winter origin. The inheritance of ear productivity, in both varieties, followed the type of complementary epistasis, with incomplete dominance and overdominance, with a large proportion, of recessive genes. In conditions of the Northern Trans-Urals, an early-ripening, yielding line was selected in F5 - Lutescens 1227-8-79, which became the ancestor of the Kazakhstanskaya rannespelaya variety. The variety has successfully passed the State variety testing and is registered in the Qostanay, North Kazakhstan and Kokchetav regions of Kazakhstan, and in the Chelyabinsk region of the Russian Federation, according to the grain quality it is included in the list of strong varieties. In the north of Kazakhstan, Kazakhstanskaya rannespelaya is cultivated on large areas. This variety, as a genetic source, has a good variety-forming ability. With its participation, 6 varieties were created in the Research Institute of the Northern Trans-Urals. Of these, Tyumenskaya 29 and Grenada are registered in 9 and 10 zones of the Russian Federation. It is used in the breeding programs of the Republic of Kazakhstan.
The T-RFLP research method in the study of rumen microbiota in dairy cows with subclinical ketosis
Authors: Yashin Anatoliy , Kasatkina Elizabeth , Prusakov Aleksey , Ponamarev Vladimir , Lunegov Alexander
Published: September 2023

The article presents the results of researches related to the study of the possibility of using the modern molecular genetics method -T-RFLP-analysis (terminal restriction fragment length polymorphism) to identify the community of microorganisms in the contents of the rumen in clinically healthy highly productive cows and cows with subclinical ketosis. The research methodology is based on the analysis of the conservative regions in the microorganisms’ genome variability. The results showed the high efficiency of the method used for the identification of microorganisms in the rumen contents in the studied animals. A large community of bacteria, archaea, protozoa and anaerobic fungi is determined in the rumen contents from highly productive cows with subclinical ketosis. The data obtained allow us to significantly amplify the information on the pathogenesis of subclinical ketosis in cows with high milk productivity. The presence of conditionally pathogenic and pathogenic microflora in sick cows in the rumen contents indicates a violation of rumen digestion, which leads to the development of concomitant non-contagious diseases in animals.
Assessment of the resistance of varieties and collection samples of flax to fusarium wilt
Authors: Simagin Alexander , Barsukov Nikolay , Zakharova Sayera , Simagina Anastasia , Kudryavtseva Ludmila
Published: September 2023

The purpose of the work is to identify samples of flax, resistant to fusarium wilt. The assessment of resistance to fusarium wilting of varieties and samples of flax-long-lived (Linum ussitatissimum L.) from the “Collection of Russian flax” of the Flax Research Institute (NIIL, Torzhok) was carried out. The experiment was conducted for three years from 2019 to 2021. Most of the samples showed average resistance to the disease. The greatest degree of resistance to fusarium wilting (87.5-100%) was shown by the the variety Sursky (86.9%) of the selection of the Flax Research Institute. The lowest resistance to the disease was shown by varieties B-100 (40.4%) and Peresvet (37.1%), their resistance indicators were lower than the susceptibility of the AR-5 standard variety (45.6%), which allows them to be classified as highly susceptible.
Antibiotic susceptibility of opportunistic pathogens in poultry egg farms
Authors: Krivonogova A.S. , Isaeva A.G. , Loginov E.A. , Moiseeva K.V. , Donnik I.M.
Published: September 2023

The composition and antibiotic susceptibility of opportunistic pathogenic microflora associated with poultry were studied. For this purpose, we obtained biomaterial at different technological areas of two poultry farms in the period of three months. The relative constancy of genus-species spectrum of microorganisms with differences in frequency of occurrence at poultry farms was established. Bacteria of genera Staphylococcus, Enterococcus, Escherichia were detected most frequently. More than 82% of E. coli isolates with intermediate sensitivity to cefuroxime were detected. In both poultry farms, more than 10% of Staphylococcus spp. were resistant to penicillins and most had reduced sensitivity or resistance to ciprofloxacin.
Improvement of the technique for the bovine genome editing using the example of knockout of the CD 209 receptor responsible to the bovine leukemia virus
Authors: Krivonogova A.S. , Isaeva A.G. , Makutina V.A. , Petropavlovsky M.V. , Deikin А. V.
Published: September 2023

The aim of this work was to evaluate the possibility of editing the CD209 gene associated with bovine leukemia virus (BLV) infection. Two ways of delivering the gene editing system into the zygote were investigated: delivery of the CRISPR/Cas9 system using a viral vector and injection of mRNA and sgRNA into the oocyte cytoplasm. The most effective was the microinjection of spCas9 protein mRNA and sgRNA targeting CD209 at the zygote stage into the cytoplasm.
The mechanism of innovative development of the agricultural sector of the economy: an empirical approach
Authors: Meshkova Natalia , Gerba Viktoriya , Boyarskaya Olga , Golovchanskaya Elena , Kramarenko Sofia
Published: September 2023

The innovative model of the agricultural sector of Russia is presented as a set of subjects and institutions whose activities are aimed at implementing innovative processes in the agricultural sector of the economy. Due to the ability to use a wide range of legal, administrative, economic, and other means of influencing the innovation sphere, it is the state that has a central role in the mechanism of innovative development. It is proved that the formation of the mechanism of innovative development of the agricultural sector of the economy should be carried out on the basis of the institutional model of innovative development of the agricultural sector. The mechanism of innovative development of the agricultural sector of the economy, developed in response to the requirements of the institutional model of the introduction of innovative technologies, is proposed. The innovative model is a recognized guideline for the strategic contours of the development of the agricultural sector, makes it possible to construct such a type of interaction of productive forces and the implementation of industrial relations, which carries the foundations of progressivity. The process of formation and optimization of the mechanism of innovative development of the agricultural sector of the economy is proposed to be divided into the following six stages, which allows us to identify potential opportunities for activating the innovative model of the agricultural sector. A methodological approach to the diagnosis of the functioning of the mechanism of innovative development of the economy has been developed, based on the technology of solving complex problems by analyzing hierarchies.
Digital platforms as a factor in strengthening national food security
Authors: Loginov Dmitry A.
Published: September 2023

Ensuring food security is one of the key areas in the management of economic security. Today, Russia's food security is sufficiently strengthened. However, a reasonable question arises about the promising directions of its development. The article explores the possibility of using digital platforms to improve the efficiency of national food security management. It is established that currently many countries of the world are betting on increasing the level of self-sufficiency in food as a fundamental condition for ensuring national food security. At the same time, the importance of criteria such as food quality and compliance of the domestic food market with the requirements of healthy nutrition is rapidly increasing. Using the example of the dairy market, it is shown that the Russian food market is quite stable and is characterized by the predominance of domestic production over imports in resources. There is an increase in exports. At the same time, there are no signs of active import substitution, the growth of domestic consumption lags behind the growth of production. To solve the current problems of food security, it is proposed to implement digital platforms in the agro-industrial complex at the stages of production of agricultural raw materials, its processing, consumption control and implementation of social policy to support the nutrition of socially vulnerable segments of the population. The use of digital platforms is aimed at improving the efficiency of national food security management.
The approach to assessing the characteristics significant for consumers when buying meat and meat products of organic origin
Authors: Biryukova Tatiana V. , Enkina Catherine V. , Vorozheykina Tatyana M. , Ashmarina Tatyana I. , Yagudaeva Natalya A.
Published: September 2023

The effect of the “healthy food” trend, which has recently been the basis of food choice among consumers, has significantly transformed approaches to buying, in particular the selection and evaluation of meat and meat products. No less serious changes have occurred in the model of the purchase decision-making process, which in turn encourages manufacturers to develop positioning, production, and sale of products at a new qualitative level relative to all market vectors, one of which is the formation of the organic food market segment. Nevertheless, despite the significant transformation of the market, at the moment the segments for a number of product categories have not been finally formed. At the moment, the existing number of criteria that are the basis of choice does not always indicate the organic origin of the product, in particular, one of such criteria is the category “farm products”, often these two concepts are interchangeable in the consumer's mind. This article attempts to evaluate the main factors and criteria for choosing meat and meat products belonging to the “organic products” class based on understanding the transformation of ideas about the process of making a decision to purchase a product, considering the formation of the “healthy food” trend. Based on the results of the study, the main vectors of the development of the marketing relationship model with the consumer are determined, the interrelation of a number of factors indicating the organic origin of the product for the consumer is formulated. The key criteria for positioning meat and meat products of organic origin have been identified. The main conclusions regarding the characteristics that are significant for the consumer when buying meat and meat products of organic origin are formulated.
Study on the Application of Demand-Side Resources to Participate in the Electricity Ancillary Services Market
Authors: Man Linkun , Chi Cheng , Gu Bing
Published: September 2023

As the scope of pilot power auxiliary services continues to expand, major provincial power companies are clarifying the main status of demand-side response resources and energy storage resources as market participants one after another. Electricity auxiliary services are developing towards diversification, and a fair, transparent, competitive and orderly market mechanism for sharing auxiliary services is taking shape. The active participation of energy storage devices, demand-side resourcesand third parties in electricity market services will promote the development of new industries such as new energy consumption, electricity market transactions and virtual power plants. This paper summaries the participation patterns and trading mechanisms of demand-side resources in domestic and international markets, analyses how domestic demand response resources can be used to participate in the ancillary services market, and makes corresponding suggestions for the development of the ancillary services market in the domestic power industry.
Energy Saving and Low-carbon Transformation Path of Guizhou Province Transportation
Authors: Wu Peng , Li Wen , Pang Bo , Li Haibo , Li Yulin , Chen Zhangyu , Xiao Shanmin
Published: September 2023

To help the transportation sector achieve the goal of the energy saving and low-carbon transformation, including highway, waterborne, urban transportation and ports. This paper sets four development scenarios to predict the carbon emission of the transportation sector in Guizhou province. Results indicate that in business-as-usual scenario, the carbon emissions show an overall upward trend; in high speed development scenario, the transportation in Guizhou province will reach a carbon peak in 2030, with a peak value of 8.76 million tons. China should actively take measures for energy saving and carbon reduction. By 2060, optimization of the energy structure contributes more carbon reduction than the optimization of transportation structure. We will promote the energy-saving and green development of China’s transportation carbon emissions.
Research on Energy-Saving Reconstruction Technology of Hospital Buildings Based on Measured Data
Authors: Wu LingQian , Xu GaoFeng
Published: September 2023

In order to effectively reduce the carbon emission in the process of building operation, the energy consumption per unit area and energy consumption system of hospital buildings were analyzed and studied. The practical application shows that the energy-saving transformation of hospital buildings in hot summer and warm winter area can effectively reduce its energy consumption, it also saves at least 654 tons of carbon dioxide annually.
The presentation of some cultural-historical resources of Vidin district and their promotion as tourist objects
Authors: Stoykova Blaga
Published: September 2023

The presentation and provision of access to the cultural values of the Vidin region (Bulgaria) by the local community aim to promote them and increase visitor’s interest. Two of the objects located on the territory of the district have been proposed for inclusion in the UNESCO World Cultural and Natural Heritage List - the Magura Cave with drawings from the Bronze Age (proposed for inclusion in 1984) and the Belogradchik Rocks (proposed for inclusion in 2011). The local cultural and historical heritage is valuable for developing regional tourism. The article aims to draw attention to the general state of Vidin's culturalhistorical and archaeological heritage, evaluated from its visitors' point of view. Based on field surveys conducted in the administrative area, conclusions and recommendations for developing cultural-historical tourism are drawn. The research results confirm the positive relationship between cultural tourism and the promotion of the cultural and historical heritage of the region through the application of some stimulating mechanisms.
Understanding Students’ Perspectives on Environmental Protection: Insights from an Empirical Study
Authors: Vladova Ina
Published: September 2023

Environmental protection is an essential factor for the sustainable development of humanity. To achieve this goal, it is necessary to promote attitudes and behaviors that help to conserve natural resources and reduce the harmful impact of human activities on the environment. Such attitudes and behaviors can be achieved through education, awareness, and changing people’s environmental attitudes. The present article will discuss some key attitudes and behaviors that help protect the environment – recycling waste, using green energy, reducing air and water pollution, supporting sustainable agriculture, etc. The study involved 393 undergraduate students, including 198 women and 195 men, from National Sports Academy “Vassil Levski”, Sofia. Students completed an online survey that measured their environmental attitudes, knowledge, and behaviors, as well as their perceptions of the effectiveness of environmental education. Environmental attitudes and behaviors can be applied in different areas of life, such as at home, work, and public places. People must realize the importance of these actions and carry them out regularly to contribute to the conservation of nature and the world’s sustainable development.
Towards a More Sustainable Future: The Importance of Environmental Education in Developing Attitudes towards Environmental Protection
Authors: Vladova Ina
Published: September 2023

This article discusses the importance of environmental education in promoting sustainable development and forming attitudes toward environmental protection. The reviewed literature identifies environmental education as a process that provides opportunities for people to engage with environmental issues and take action to improve the environment. The goal of environmental education is to create environmental literacy and develop a greater respect for nature that will lead to informed and responsible decisions. Incorporating environmental education into the curriculum is essential, seeking to change public opinion and instill social responsibility. The hallmarks of environmental education are its relevance to sustainable development, interdisciplinary approach, and emphasis on real-world and practical activities. Understanding environmental education and its role in shaping attitudes towards environmental protection is essential to tracking its practical implications in education.
Application of Digital Technologies in Controlling Urban Sprawl
Authors: Geshkov Marin
Published: September 2023

Urban sprawl has been defined as an excessive conversion of rural land into urban land or excessive increase of the city beyond the optimal city size. Urban sprawl became a hot topic first in the United States, where the low-density city the problem emerged in the late 70s and early 80s. In Europe, urban sprawl wasn’t an issue until very recently, predominantly due to the structure of the European cities, which are traditionally more concentrated and densely populated, in contrast to the US cities. However, today we observe signs of urban sprawl in European cities, such as excessive decentralization, road congestion, lack of open space, overpopulation, etc. Recently urban city planners started using contemporary digital technologies to measure and control urban sprawl. This study discusses modern digital technologies used in present-day city planning.
Intelligent Solutions in the Management of Marketing
Authors: Biolcheva Petya
Published: September 2023

Marketing is among the sectors in which digitization and the application of intelligent tools based on artificial intelligence is at a high level. It is a known fact that in the short term, the widespread penetration of AI in the marketing of any business organization will be a guarantor of competitive advantage. The purpose of this paper is to outline the main directions for the development of intelligent marketing. To establish the path to intelligent marketing strategies and outline the directions of business organizations, to achieve high flexibility and adaptability to market requirements. Through analysis and synthesis of intelligent marketing innovations, the paper proposes a roadmap for implementing intelligent marketing (AIM) solutions suitable for individual types of business organizations. The conclusions drawn illustrate the competitive advantages for businesses based on intelligent marketing strategies.
The Green Deal Industrial Plan for the Net-Zero Age – challenges for the Bulgarian Industry
Authors: Ivanov Ivaylo
Published: September 2023

On 1st of February 2023, the European Commission presented an Industrial plan in the context of the Green Pact to boost the competitiveness of Europe's zero net emissions industry and support the rapid transition to climate neutrality. The plan aims to provide a more favourable framework for the expansion of EU production capacity for the zero net emission technologies and products needed to meet Europe's ambitious climate targets. The aim of the study is to identify the challenges that this plan poses to the Bulgarian industry. In Bulgaria, industrial transformation is a continuous process. In the context of the overall development of this key economic sector, the importance of the concepts of Industry 4.0 and 5.0 should be considered, along with the assessment of the risks that disruptive technologies bring.
Factors shaping human capital in rural areas
Authors: Blagoev Anton
Published: September 2023

Human capital is a vital category of the economy in order to achieve economic stability. The combination of certain personal, social, professional business skills, abilities and motivation help to increase the efficiency of production in the rural areas.. The goal of this publication is to analyze and explore some factors of human capital formation in rural areas. The study covers demographic trends, educational attainment, technological changes, availability of health facilities in rural areas. On the basis of the analytical part of the report, conclusions are drawn on the potential of human capital to achieve a sustainable and stable rural areas.
Gender change in sport through the lens of law
Authors: Dimitrov Vasil
Published: September 2023

This report aims to analyse gender change and legal cases related to participation in sports, sports ethics, sports legal relations, regulation and others. In order to solve the main tasks, achieve the goal and prove the hypothesis, a complex methodology is applied: a legal method oriented to the practice of law enforcement, a sociological - axiological method, a comparative analysis between methodological concepts, the judicial practice in Bulgaria and the EU. The analysis interprets decisions of the courts in Bulgaria, the EU and the IOC, as well as psychological and normative aspects related to gender change. European gender reassignment practice, as well as the conditions for legal gender reassignment, are also reviewed. Conclusion: legal gender change does not disturb the balance between personal and public relations, including civil law turnover, but this possibility introduces ambiguity, unpredictability and instability in sports legal relations.
Künstliche Intelligenz in der Radiologie
Authors: Kromrey Marie-Luise , Grothe Sascha , Nell Christopher , Rosenberg Britta
Published: September 2023

Die klinische Radiologie mit ihren digitalen Daten ist geradezu
prädestiniert für den erfolgreichen Einsatz der
künstlichen Intelligenz (KI). Am Beispiel verschiedener praktischer
Anwendungen wird nachfolgend dargestellt, wo und wie die KI in der Radiologie
eingesetzt wird und dabei auch die Frage beantwortet, inwieweit sie
Radiolog*innen ersetzen kann.
Salt and Aldosterone – Reciprocal and Combined Effects in
Preclinical Models and Humans
Authors: Chen Li , Adolf Christian , Reincke Martin , Schneider Holger
Published: September 2023

Primary aldosteronism is an endocrine disorder caused by excessive production of
aldosterone by the adrenal glands, and is recognized as the most important cause
of endocrine hypertension. With specific therapy, this type of hypertension is
potentially curable. In the general population, high salt intake increases the
risk for cardiovascular diseases like stroke. In populations with aldosterone
excess, observational and experimental data suggest that aldosterone-induced
organ damage requires a combination of high dietary salt intake and high plasma
aldosterone, i.e., plasma aldosterone levels inappropriately high for salt
status. Therefore, understanding the relationship between plasma aldosterone
levels and dietary salt intake and the nature of their combined effects is
crucial for developing effective prevention and treatment strategies. In this
review, we present an update on findings about primary aldosteronism and salt
intake and the underlying mechanisms governing their interaction.
Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the “Connection Trial”
Authors: Neu Josef , Ashley Patricia , Chowdhary Vikas , Lampland Andrea , Porcelli Peter , Rothstein Robert , Slancheva Boriana , Kronström Anders , Rastad Jonas , Strömberg Staffan , Thuresson Marcus ,   The Connection Study Group
Published: September 2023

Objective Investigate daily feeding volumes and their association with clinical variables in the early postnatal care of premature infants of the “Connection Trial.”

Study Design A total of 641 infants of 510 to 1,000-g birth weight (BW, mean: 847 g) and mean 27 weeks' gestational age at birth (GA) were analyzed for total daily enteral (TDE) feeding volumes of 10, 20, 40, 80, and 120 mL/kg/d and their association with 24 clinical variables. Uni- and multivariable Cox regression models were used to calculate hazard ratios (HR) with 95% confidence intervals as a measure of the chance of reaching each of the TDE volumes.

Results Daily feeding volumes were highly variable and the median advancement from 10 to 120 mL/kg/d was 11 mL/kg/d. Univariable analyses showed the lowest chance (HR, 0.22–0.81) of reaching the TDE volumes for gastrointestinal (GI) serious adverse events (SAEs), GI perforation, GI obstruction, and necrotizing enterocolitis, as well as respiratory SAEs, persistent ductus arteriosus, and hypotension. Each GA week, 100-g BW, and point in 5-minute Apgar score at birth associated with 8 to 20% increased chance of reaching the TDE volumes. Multivariable analyses showed independent effects for BW, GA, Apgar score, GI SAEs, abdominal symptoms/signs, respiratory SAEs, days on antibiotics, and hypotension.

Conclusion This observational analysis demonstrates the variable and cautious progression of enteral feedings in contemporary extremely low BW infants and the extent to which clinical variables associate with this progression.

Key Points
Eigenvector centrality in simplicial complexes of hypergraphs
Authors: Liu Xiaolu , Zhao Chong
Published: September 2023

Hypergraph is the model of relations lying in clusters of objects. Identifying vital nodes is a fundamental problem in the analysis of the hypergraph. To reflect the multilayer feature of the hypergraph, in this paper, we deconstruct the hypergraph into a simplicial complex and analyze the homological dual relations of boundary and coboundary between simplices. For clarity, these two relations are summarized into a bidirectional graph, called the simplicial diagram, which provides a global framework for the exploration of the hypergraph. To determine the node importance in the hypergraph, we propose a parameter-free eigenvector centrality for weighted hypergraphs in terms of a simplicial complex, named Simplicial DualRank centrality. For each simplex, we define two indices of importance, the inner centrality and the outer centrality. Inner centrality transmits according to the relation of coboundary, which converts to outer centrality at the hyperlinks; in duality, outer centrality transmits according to the relation of boundary, which converts to inner centrality at the nodes. Therefore, a circuit of centrality is constructed on the simplicial diagram, the steady state of which defines the Simplicial DualRank centrality of all the simplices in the hypergraph. Moreover, we apply the Simplicial DualRank centrality to weighted complex networks, which results in a variant of the classical eigenvector centrality. Finally, experimental results in a science collaboration dataset show that the Simplicial DualRank can identify Nobel laureates from the prize-winning papers in Physics, top scientists should select collaborators more carefully to maintain their research quality, and scholars tend to find relatively effective collaborations in their future research.
Spray combustion characteristics of a gas–liquid pintle injector with variable swirl intensities
Authors: He Chengming , Luo Weihang , Zhang Peng , He Zhixia , Yue Lianjie
Published: September 2023

The present paper experimentally verified and computationally explained an improved design concept of the spray combustion of a gas–liquid pintle injector with variable swirl intensities. By pintle injector, we mean a promising injector for the throttleable engines with variable thrust capacities, which features the moveable pintle continuously controlling the mass flow rates of fuel and oxidizer where the radial and axial flows encounter to form a spray cone and spray atomization. First, the cold flow test was conducted to study the swirl effects on the spray angle, followed by the combustion test to study the total pressure and the specific impulse under different swirl intensities. The results show that the swirl enhances the combustion performance by increasing the total pressure and specific impulse. Second, the swirl-assisted spray was numerically simulated based on a validated volume-of-fluid method to explain the experimental findings. The diameter distribution and spatial distribution of dispersed droplets were analyzed by the Sauter mean diameter (SMD) and the Voronoi tessellation, respectively. The results show that the swirl significantly promotes the breakup of liquid jet or film, producing smaller SMDs and a more uniform spatial distribution of dispersed droplets. The consolidated correlation between the non-reacting spray characteristics and the combustion performance suggests that the proposed methodology can be used to fast prescreen pintle injector designs.
Analysis of unsteady non-Newtonian Jeffrey blood flow and transport of magnetic nanoparticles through an inclined porous artery with stenosis using the time fractional derivative
Authors: Yadeta Habtamu Bayissa , Shaw Sachin
Published: September 2023

In the present study, a Caputo–Fabrizio (C–F) time-fractional derivative is introduced to the governing equations to present the flow of blood and the transport of magnetic nanoparticles (MNPs) through an inclined porous artery with mild stenosis. The rheology of blood is defined by the non-Newtonian visco-elastic Jeffrey fluid. The transport of MNPs is used as a drug delivery application for cardiovascular disorder therapy. The momentum and transport equations are solved analytically by using the Laplace transform and the finite Hankel transform along with their inverses, and the solutions are presented in the form of Laplace convolutions. To display the solutions graphically, the Laplace convolutions are solved using the numerical integration technique. The study presents the impacts of different governing parameters on blood and MNP velocities, volumetric flow rate, flow resistance, and skin friction. The study demonstrates that blood and MNP velocities boost with an increase in the fractional order parameter, Darcy number, and Jeffrey fluid parameter. The volumetric flow rate decreases and flow resistance increases with enhancement in stenosis height. The non-symmetric shape of stenosis and the rheology of blood decrease skin friction, whereas enhancement in MNP concentration increases skin friction. A comparison of the present result with the previous work shows excellent agreement. The present study will be beneficial for the field of medical science to further study atherosclerosis therapy and other similar disorders.
Non-adiabatic dissociation dynamics of Ar⋯I2 (E, v) intermolecular vibrational levels probed using velocity-map imaging
Authors: Makarem Camille , Loomis Richard A.
Published: September 2023

Ion time-of-flight velocity-map imaging was used to measure the kinetic-energy distributions of the I2 ion-pair fragments formed after photoexcitation of Ar⋯I2 complexes to intermolecular vibrational levels bound within the Ar + I2 (E, vE = 0–2) potential energy surfaces. The kinetic-energy distributions of the I2 products indicate that complexes in the Ar⋯I2 (E, vE) levels preferentially dissociate into I2 in the D and β ion-pair states with no change in I2 vibrational excitation. The energetics of the levels prepared suggest that there is a non-adiabatic coupling of the initially prepared levels with the continuum of states lying above the Ar + I2 (D, vD = vE) and Ar + I2 (β, vβ = vE) dissociation limits. The angular anisotropies of the I2 product signals collected for many of the Ar⋯I2 (E, vE) levels have maxima parallel to the laser polarization axis. This contradicts expectations for the prompt dissociation of complexes with T-shaped geometries, which would result in images with maxima perpendicular to the polarization axis. These anisotropies suggest that there is a perturbation of the transition moment in these clusters or there are additional intermolecular interactions, likely those sampled while traversing above the attractive wells of the lower-energy potentials during dissociation. I2 (D′, vD′) products are also identified when preparing several of the low-lying levels localized in the T-shaped well of the Ar + I2 (E, vE = 0–2) potentials, and they are formed in multiple νD′ vibrational levels spanning energy ranges up to 500 cm−1.
Effect of muzzle gas on forward blood spatter from a gunshot: Experiments with a supersonic de Laval nozzle
Authors: Huh Jungwoo , Kim Seongdong , Bang Boo-Hyoung , Aldalbahi Ali , Rahaman Mostafizur , Yarin Alexander L. , Yoon Sam S.
Published: September 2023

For bloodstain pattern analysis (BPA), interpreting statistically reliable data on a crime scene resulting from gunshots is a great challenge. This is due to various uncertainties, including blood rheology, hematocrit, coagulation, surrounding atmospheric conditions, victim's peculiarities, gun types, geometries, etc. In addition, muzzle (propellant) gases that follow the bullet may influence the aerodynamics of blood spatter in the cases of short-range shooting. We studied the muzzle gas effect on forward blood spatter. Muzzle gas can penetrate the wound channel and be ejected from the bullet exit hole affecting the forward blood spatter. Experiments with blood atomization by a gas flow issued from a supersonic de Laval converging–diverging nozzle are conducted. Defibrinated sheep blood was enclosed in a thin solid cylinder, which was filled by a supersonic air flow ejected from a de Laval nozzle, mimicking the muzzle gas flow through a wound channel. The mass flow rate of the supersonic air stream was varied by controlling the upstream chamber pressure. It was found that the number counts of the forward blood spatter from the muzzle gas blasting peaked at relatively shorter distances from the exit hole compared to the one that would be caused by a bullet. The effects of the muzzle gas and bullet could cause the formation of a bimodal spatter distribution on the floor behind the exit hole. These findings imply that atomization events owing to muzzle gas cause coarser atomization than that of a bullet, which could facilitate BPA in distinguishing certain homicides from staged suicides.