bluuebunny/crossref_metadata_2025 huggingface dataset:
Government Spending and Indonesia's Multidimensional Poverty 2018-2020
Authors: Ramadhani Azzahra Alifa , Ridwan Endrizal
Published: December 2024

This research aims to analyze the effect of government spending on multidimensional poverty in Indonesia in 2018-2020. The government expenditure used is government expenditure for housing functions, public facilities and social assistance expenditure. This research uses a quantitative approach and Tobit panel regression techniques as well as secondary data for 2018-2020. The research results show that government spending, both government spending for public facilities housing functions and social assistance spending, has a positive and significant effect on multidimensional poverty in Indonesia. This research recommends to the Government that in making expenditure policies it is necessary to examine more broadly the impact on multidimensional poverty. Furthermore, the Government needs to evaluate and review the effectiveness of policies that have been implemented to reduce poverty, especially multidimensional poverty, which can be done through budget decomposition based on programs, so that the effect of spending on poverty can be seen in more detail.
Analysis of Risk Management Implementation in A Holding Company: Infrastructure, Resources, and Risk Management Governance
Authors: Hasan Hasbiyallah , Priyarsono Dominicus Savio , Ramadyanto Widodo
Published: December 2024

X is a state-owned enterprise operating as a holding company across various industries. In 2022, X's total consolidated assets reached Rp 49.1 trillion, encompassing financial services, industrial estates, construction, water management, media, and technology. The expansion into a conglomerate brings challenges and uncertainties, necessitating a systematic risk management process, as accommodated by the regulations in Minister of SOE Regulation Number 2 of 2023 on Guidelines for Governance and Significant Corporate Activities of State-Owned Enterprises. This research focuses on analyzing the alignment and identifying gaps in X's risk management practices based on this regulation, as well as proposing steps to enhance risk management effectiveness in X to face business challenges. The study employs a triangulation approach through document observation, interviews, and literature review. The findings reveal several gaps in the implementation of risk management at X, highlighting areas for improvement, including three lines of defense implementation, enhancing a risk-aware culture, ensuring the independence of the risk management function in its subsidiaries, involving and evaluating the roles of the board of commissioners and the director of risk management, and optimizing the integration process of risk management with its subsidiaries, both in policy and practice
Lifestyle Analysis on Purchasing Decisions Through Price Perception as a Mediating Variable
Authors: Haq Qubaila Nurul , Ramdan Asep Muhamad , Mulia Z Faizal
Published: December 2024

Fashion is an inseparable part of daily appearance and style and every country has its own fashion and fashion is able to change the country's economy. The purpose of this study was to determine the effect of price perception on life style, to determine the effect of life style on purchasing decisions and to determine the effect of price perception in mediating the relationship between life style and purchasing decisions. The method used in this research is descriptive and associative method through quantitative approach. The population in this study were residents of Sukabumi City who use Uniqlo. The sample used in this study amounted to 200 people. The sample was taken based on Malhotra's theory, that a minimum communality of 0.5 must be estimated with a sample of at least 200. The research data used in this study include primary data and secondary data, namely observation, interviews, questionnaires, literature studies, and documentation. The results of this study Lifestyle has a direct and significant effect on price perception on Uniqlo users in Sukabumi City. Price perception has a direct and significant effect on purchasing decisions for Uniqlo users in Sukabumi City. Price perception mediates the relationship between lifestyle and purchasing decisions for Uniqlo users in Sukabumi City.
The Impact of Artificial Intelligence on Auditing Processes and Accuracy: A Future Outlook
Authors: Fidyah Feny , Usman Susanti , Eki Pradita Afrila , Mieta Setyawati Dyah
Published: December 2024

Artificial Intelligence (AI) is revolutionizing auditing processes, promising significant improvements in accuracy, efficiency, and risk management. This literature review explores the transformative impact of AI on auditing practices and outlines future prospects. AI technologies such as machine learning, natural language processing, and robotic process automation are being integrated into auditing systems, enabling real-time data analysis, anomaly detection, and predictive insights. These advancements not only enhance traditional auditing methodologies but also introduce new approaches capable of handling large volumes of data with unprecedented speed and precision. This article synthesizes current research and industry trends to highlight AI's role in addressing auditing challenges, including fraud detection, compliance monitoring, and audit quality enhancement. Moreover, it examines the implications of AI adoption for auditors, emphasizing the need for upskilling in data analytics and AI technologies. Looking forward, the article discusses potential future developments such as AI-driven continuous auditing, blockchain integration, and ethical considerations in AI-augmented audits.
The Effect of Job Analysis and Career Development Through Competency on Employee Performance
Authors: Erwan Erwan , Zahari M. , Hapsara Osrita
Published: December 2024

The objectives of this study are: 1) to describe job analysis (JA), career development, competencies, and employee performance; 2) to analyze the direct and indirect effects of job analysis (JA) and career development on competencies; 3) to assess the direct and indirect effects of job analysis (JA) and career development on employee performance; 4) to determine the effect of competencies on employee performance; and 5) to evaluate the effect of job analysis (JA) and career development on employee performance through competencies. The research method employed descriptive and verificative analysis with a path analysis approach. The sample consisted of 62 respondents, and data were collected through a census survey using a questionnaire. The findings of the study are as follows: 1) The variables of job analysis, career development, and competencies are in fairly good condition, while performance is categorized as moderate; 2) Job analysis (JA) and career development have direct and indirect effects on competencies; 3) Job analysis and career development have both direct and indirect effects on employee performance; 4) Competencies have an effect on employee performance; 5) Job analysis and career development through competencies impact employee performance.
Determinants Of Service Quality, Convenience And Costs On Satisfaction And Loyalty Communities In Sharia Pawnshops Cluster 1 Medan
Authors: Syahputra Zulian , Batubara Maryam , Ahmadi Bi Rahmani Nur
Published: December 2024

Using a quantitative methodology, this study analyzes primary data from 10 Pegadaian Syariah AR Hakim Medan customers via questionnaires. Sampling methodology is the method that is used. Subsequently, route analysis and SPSS Version 25 software were used to process and evaluate the gathered data. Tests for instrument validity and reliability, statistical tests (determination test, partial test (t-test), and simultaneous test (f-test), and testing for classical assumptions (data normality, multicollinearity, and heteroscedasticity) were all included in the study. The findings of the study indicate that although mun'ah fees do not significantly affect customer happiness, service quality and convenience do have a beneficial impact on contentment. Customer loyalty is positively impacted by customer pleasure. The significance test findings demonstrate that mun'ah fees have no discernible impact on consumer happiness or loyalty. However, with a 95% trust level and a 5% mistake rate, service quality and convenience have a major impact on client loyalty via satisfaction.
The Influence of Independent Board of Commissioners, Audit Committee and Leverage on Tax Avoidance in Health Sector Companies Listed on the Indonesia Stock Exchange (IDX) for the 2018-2022 Period
Authors: Kawengian Klarisa , J. Sondakh Jullie , R. N. Wokas Heince
Published: December 2024

Tax is one of the main sources of national income in Indonesia, playing a crucial role in supporting the country's finances and development. For companies, tax is considered a financial burden that can reduce profits. Therefore, companies tend to engage in legal tax planning, known as tax avoidance, to reduce the tax burden. This study aims to examine the influence of independent board of directors, audit committee, and leverage on tax avoidance in healthcare sector companies listed on the Indonesia Stock Exchange during the period 2018-2022. The sampling method used is purposive sampling, resulting in 12 companies out of a total of 33 companies in the population. The analysis was conducted using multiple linear regression with the assistance of IBM SPSS version 29. The results show that leverage has an effect on tax avoidance, while independent board of directors and audit committee do not affect tax avoidance.
The Position of the Murabahah Contract in BSI Griya Hasanah Financing at BSI KC Palangkaraya Diponegoro
Authors: Syawaliah Syawaliah , Muzalifah Muzalifah , Adlina Fadiah
Published: December 2024

This study aims to determine the position of the murabahah contract in BSI Griya Hasanah Financing at Bank Syariah Indonesia Palangkaraya Diponegoro Branch Office. In addition, to find out how the implementation of BSI Griya Hasanah financing products with murabahah contracts. The method used is qualitative with a descriptive analytical method. Data collection techniques through interviews with Bank Syariah Indonesia KC Palangkaraya Diponegoro, as well as a documentation approach and also literature studies related to this study. The results of the study found that the BSI Griya Hasanah financing product is appropriate if paired with a murabahah contract because in principle the transaction, the Islamic bank will purchase the house or apartment desired by the customer (the bank acts as the homeowner) and then sell the house or apartment to the customer in installments. This murabahah contract also has a strong foundation from the three basic laws of Islam, the Qur'an, Hadith and Ijma. Based on Q.S Al-Baqarah:275, hadith from Suhaib Ar-Rumi r.a and Fatwa of the National Sharia Council No. 04/DSN-MUI/2000 concerning murabahah financing and multi-service financing No. 44/DSN-MUI/VIII/2004.
Determinants That Influence Financial Sustainability Through Profitability
Authors: Adhim Chairul , Mulyati Mulyati
Published: December 2024

This research aims to determine whether LDR, NPL, BOPO, and CAR have a direct effect on FSR through ROA in banks listed on the Indonesia Stock Exchange. The sample was selected using purposive sampling with a total sample of 40 banks. The research data was tested using path analysis. The results of the direct analysis show that LDR does not affect FSR, while NPL, BOPO, and CAR have a negative and significant effect on FSR. Additionally, ROA has a positive and significant effect on FSR. Furthermore, LDR and CAR do not affect ROA, whereas NPL has a positive and significant effect, and BOPO has a significant negative effect on ROA. The results of the indirect analysis show that LDR, NPL, and CAR do not affect FSR through ROA, whereas BOPO has a significant negative effect on FSR through ROA.
Tourist Attractions, Perceived Value, Destination Image, and Loyalty Motivation: A Mediating Variable Analysis
Authors: Desy Surya Elfitra , Afrina Siregar Nur , Suranta Sinukaban Dedy
Published: December 2024

This study examines and analyzes various factors affecting tourist satisfaction and loyalty towards the agro-tourism destination in Tanah Karo. This study utilizes a quantitative research approach with a descriptive methodology to analyze the impact of various factors on tourist loyalty to the agro-tourism destination in Tanah Karo. The research aims to evaluate the effects of tourist attractions, perceived value, destination image, and motivation on tourist loyalty, with satisfaction as a mediating variable. Descriptive analysis will interpret the data, while quantitative analysis will employ statistical tools for hypothesis testing. The study, conducted in Berastagi, Tanah Karo, will use interviews and surveys to collect data from tourists aged 18 to 55 who have visited the destination more than twice. Data will be gathered through questionnaires and secondary sources and analyzed using Structural Equation Modeling with Partial Least Squares. This analysis will include assessing model validity, reliability, and hypothesis testing to understand the direct and indirect effects of the studied variables on tourist loyalty. Based on the research conducted at Agrowisata Tanah Karo, it can be concluded that tourist attractions, perceived value, destination image, and motivation significantly influence tourist satisfaction. Higher satisfaction, in turn, positively impacts tourist loyalty. Specifically, the appeal of tourist attractions and the perceived value contribute to greater satisfaction, which fosters loyalty. Additionally, the destination image and the motivation behind tourists' visits enhance satisfaction and loyalty. Tourist satisfaction mediates the relationship between attractions and loyalty and between perceived value, destination image, and loyalty. Thus, improving these factors can increase tourists' satisfaction and loyalty.
Performance Model of Courier Service in Pademangan, North Jakarta: Discipline, Incentives, and Competence
Authors: Suryana Lilis
Published: December 2024

This study aims to analyze the performance of couriers in the expedition industry in the Pademangan area of North Jakarta. The research sample does not include the entire population but only a subset. The sampling method follows the theory of Hair, which provides guidelines for determining sample size in structural equation modeling (SEM). Data for this research were collected directly through a questionnaire, which is a measurement tool containing a series of written questions or statements given to respondents to gather responses relevant to the research needs. Primary data were obtained from the distribution of the questionnaire, with research variables including Performance, Management Information Systems, Training, and Organizational Culture. The data were analyzed using Partial Least Squares (PLS) methodology. Work discipline significantly affects courier performance, while incentives and competence do not have a significant impact. The three independent variables together explain 80.9% of the variation in courier performance. The company needs to reassess its incentive programs and competency development to enhance their effectiveness and consider further research to identify additional factors influencing courier performance.
The Financial Distress, Profitability, and Leverage as Antecedents of Audit Delay: An Empirical Study of the Food and Beverage Subsector
Authors: Al Farisi Salman , Anjarwati Sri
Published: December 2024

This research aims to find out whether every year audit delays are affected by Financial distress, Profitability,
and Leverage. The sample came from the Indonesia Stock Exchange (IDX) by collecting data and then using the Secondary
Variable Quantitative Method and data tabulating with the SPSS application. The results will prove whether there is a
decrease or increase in the accuracy of the length of time for completing audit reporting during the 2018-2022 period. The
results of this study have practical implications for investors to look at audit delays as measured by Financial Distress,
Profitability and Leverage. The researcher describes the importance of company measurement to find out how long the
auditing report takes obtained from Financial Distress, Profitability and Leverage
Analysis of Export Barriers of Honey Pineapple Commodity in Purbalingga Regency
Authors: Ayu Fadillah Sekar , R Indika Deru
Published: December 2024

Pineapple production is increasing globally due to the demand for the fruit in the food processing industry to the manufacture of snacks. Purbalingga Regency has not maximized this potential because some MSMEs have stopped and have never exported. This study aims to determine the factors inhibiting the export of honey pineapple commodities inPurbalingga Regency. The technique used was unstructured interviews with 6 resource persons, namely Nanas-qu, Almeidah, the Department of Industry and Trade (Disperindag), the Department of Cooperatives and SMEs (Diskopukm), the FTA Support Center, and export practitioners. The results showed that Honey pineapple MSMEs in Purbalingga Regency struggle to set competitive export prices due to inability to purchase canning machines, reliance on external services, high export costs, and limited negotiation abilities, resulting in low product competitiveness and high selling prices. MSMEs in Purbalingga Regency rely significantly on their own funds for canning machinery, which is insufficient to cover operating expenses. Financial recording constraints limit access to working capital credit programs. Sufficient operating capital is required for operations and annually certificate audits when exporting honey pineapple. Optimal cooperation between pineapple stakeholders and district governments must be done to increase Indonesian pineapple exports to global markets.
Does SDGs Goal 8 Encompass in Stakeholders’ Roadmap of Indonesia’s Sharia Banking Journey: A preliminary exploration
Authors: Suprianto Suprianto , Luthfi Zuhdi Muhammad , Huda Nurul , S Basir
Published: December 2024

This study's objective is to present an interlinkage framework and analytical options through relevant reports and scientific publications of the roadmap that have been developed by institution as a stakeholder. It assesses the interlinkages between stakeholders’ roadmap and the comprehensive interactions among supported sector mentioned in these studies provides a key perspective for assessing the accomplishment of Sustainable Development Goals (SDGs) goal 8 objectives and its implementation.
Using qualitative research approach that focused on understanding the nature of approaches or strategies that are interrelated between stakeholders’ roadmap that had the largest number of interlinkages and stimulate dialogue on the importance of aligning a broad exposure of stakeholders in achieving Decent Work and Economic Growth or SDGs goal 8 in Indonesia.
A connection between approaches or strategies in each roadmap that linked with SDGs goal 8 through the same strategy represented in the graph using KUMU representing a direct relationship between a node and other node in the network. Overall, the result indicates that support to attain SDGs goal 8 were encompassing in various approaches or strategies in stakeholders’ roadmap.
Marketing Strategy of the Samosir Lake Toba Regency Culture and Tourism Office in Increasing the Number of Tourists
Authors: Marpaung Durahman , Tamba Dang Panagaman
Published: December 2024

The urgency of this research is that this research is important because it can provide an in-depth look at the strategies implemented by the Samosir Regency Culture and Tourism Office, so that concrete recommendations can be made to increase the attractiveness and popularity of these tourist destinations. This research aims to provide a deeper understanding of the challenges and opportunities faced by the Samosir Regency Culture and Tourism Office in expanding the number of tourists. The research methods used in this research are data collection obtained from observations, interviews with research subjects, and documentation studies, literature studies, identifying problems, preprocessing, analyzing data using SWOT analysis, BCG analysis, SPACE analysis, and QSPM analysis, data analysis results, final evaluation, research approach with mix method. The results of SWOT analysis on the evaluation of internal factors IFE and evaluation of external factors EFE show that the internal and external positions are in quadrant I, in a growing position and must continue to be improved. The results of the BCG matrix evaluation, Samosir Lake Toba Regency tourist destinations are classified in the Stars position. The results of the SPACE matrix calculation, the tourist position of Samosir Lake Toba Regency is in an aggressive position that occurs when all dimensions are positive.  Based on the results of QSPM, 3 prioritized strategies can be taken and implemented as the main steps in developing tourist destinations.
The Effect of Profitability and Deviden Policy on Company Value (Case Study in the Healthcare Sector Listed on the Indonesia Stock Exchange 2019-2023)
Authors: Lestari Firda Maulani , Supriyatna Yayat , Sari Maya
Published: December 2024

This study examined the impact of sustainability and dividend policy on the value of healthcare companies listed on the Indonesia Stock Exchange (BEI) from 2019 to 2023. The dependent variable in this analysis was company value, represented by the Price to Earnings Ratio (PER), while the independent variables included sustainability, measured by Return on Assets (ROA), and dividend policy, expressed through the Dividend Payout Ratio (DPR). A linear regression analysis was employed using data derived from the companies' financial statements. The results revealed that sustainability had a significant positive effect on company value, and dividend policy also had a positive contribution. These findings offer valuable insights for both investors and management in formulating financial strategies to enhance the value of healthcare companies. This research is expected to contribute to the growth of financial literature and managerial practices in Indonesia
The Value of Firm: The Influence of Capital Structure and Profitability in Supermarket Sub-industry Companies Listed on the Indonesia Stock Exchange for the 2018-2023 Period
Authors: Setiawan Rudi , Hertina Dede
Published: December 2024

One of important role for the company is the perception of the community, especially investors in shaping the company's image through the value of firm. Companies that are able to manage resources efficiently will be more successful in increasing their value of firm. Therefore, the purpose of this study is to analyze the effect of Debt to Equity Ratio, Return on Assets, Return on Equity, and Net Profit Margin partially on Price to Book Value in supermarket sub-industry companies listed on the Indonesia Stock Exchange for the 2018-2023 period. The method used is quantitative descriptive method with the data used is secondary data which is annual financial reports. The data analysis technique uses panel data regression techniques through Eviews 12. The results of this study indicate that Debt to Equity Ratio and Return on Equity have no effect on Price to Book Value, Return on Assets has a positive and significant effect on Price to Book Value, and Net Profit Margin has a negative and significant effect towards Price to Book Value.
Determinants Of Organizational Transformation, Corporate Culture, On Corporate Performance Mediated By Organizational Citizenship Behavior At PT. Angkasa Pura Aviasi
Authors: Budi Karyono Aris , Yuliantini Yuliantini , Agusinta Lira , Setyawati Aswanti , Tatiana Yana
Published: December 2024

This study aims to identify and analyze the determinants of Organizational Transformation and Corporate Culture on Corporate Performance with Organizational Citizenship Behavior as an intervening variable at PT Angkasa Pura Aviasi. The sample in this study was determined using the Slovin formula, resulting in a total of 232 employees of PT Angkasa Pura Aviasi as respondents. Data collection techniques used in this study included questionnaires and interviews, while the research approach was quantitative and employing SEM-PLS statistical analysis. The data was processed using SmartPLS 3.3.3 software. The results of the study demonstrate that Organizational Transformation has a direct positive and significant effect on Corporate Performance with a path coefficient value of 0.873, P-Values = 0.000, T-statistic = 32.568. Corporate Culture also has a direct positive and significant effect on Corporate Performance with a path coefficient value of 0.157, P-Values = 0.002, T-statistic = 2.935. The influence of Organizational Transformation on Organizational Citizenship Behavior shows a path coefficient value of 0.180, P-Values = 0.000, and T-statistic = 7.256. The influence of Corporate Culture on Organizational Citizenship Behavior has a path coefficient value of 0.157, P-Values = 0.000, and T-statistic = 3.6374. The influence of Organizational Transformation on Corporate Performance through Organizational Citizenship Behavior shows a path coefficient value of -0.009, P-Values = 0.248, and T-statistic = 0.681. The influence of Corporate Culture on Corporate Performance through Organizational Citizenship Behavior shows a path coefficient value of -0.042, P-Values = 0.236, and T-statistic = 0.721. Finally, the influence of Organizational Citizenship Behavior on Corporate Performance shows a path coefficient value of -0.052, P-Values = 0.235, and T-statistic = 0.722.
Keywords: Organizational Transformation, Corporate Culture, Organizational Citizenship Behavior, Corporate Performance.
Penerapan Asas Kebebasan Berkontrak dalam Perjanjian Kemitraan dan Pengaruhnya Terhadap Praktik Persaingan Usaha Tidak Sehat
Authors: Sola Kira Joseph Hugo Vieri Iusteli , Richard C. Adam
Published: December 2024

Penelitian ini membahas penerapan asas kebebasan berkontrak dalam perjanjian kemitraan serta pengaruhnya terhadap praktik persaingan usaha tidak sehat. Asas kebebasan berkontrak memungkinkan para pihak untuk menetapkan syarat perjanjian secara mandiri tanpa paksaan, namun pada praktiknya sering kali terjadi ketidakseimbangan dalam perjanjian kemitraan antara pelaku usaha besar dan Usaha Mikro, Kecil, dan Menengah (UMKM). Melalui pendekatan yuridis normatif dan studi kasus, penelitian ini menemukan bahwa perjanjian kemitraan yang bersifat baku cenderung menekan pihak UMKM, menimbulkan praktik persaingan yang tidak sehat. Studi kasus pada Putusan KPPU No. 09/KPPU-K/2020 menunjukkan perlunya intervensi hukum dalam perjanjian baku untuk melindungi pihak yang lebih lemah. Dengan adanya kebijakan perlindungan terhadap UMKM, perjanjian kemitraan diharapkan dapat mengakomodasi prinsip kebebasan berkontrak yang lebih adil dan seimbang. Penelitian ini menegaskan pentingnya revisi perjanjian yang mendukung persaingan usaha sehat sesuai dengan Undang-Undang Nomor 5 Tahun 1999.
Kepastian Hukum Terhadap Jabatan Notaris Yang dinyatakan Pailit
Authors: Putri Nabila Aulia
Published: December 2024

Bankruptcy regulations in Law Number 37 of 2004 as amended by Law Number 2 of 2014 concerning Notary Positions, especially Article 12 letter a, cause different interpretations and conflict with bankruptcy regulations regulated in Law Number 37 of 2004 concerning Bankruptcy and Postponement of Debt Payment Obligations. So this research aims to further analyze bankruptcy in the position of Notary. The type of research used is a doctrinal approach using a statutory approach and using primary legal materials and secondary legal materials. The research results concluded that Article 12 letter a of the Law on the Position of Notaries provides legal implications that a Notary will be dishonorably dismissed if the Notary is declared bankrupt by the Court. Meanwhile, in the Law on Bankruptcy and Suspension of Debt Payment Obligations, the consequences of bankruptcy only relate to the debtor's assets and the debtor still has civil rights such as carrying out his position or profession.
Evaluating Profitability of Red Mud Based Geopolymer Brick by Using The Cost Benefit Analysis Framework
Authors: Pesch Kevin Heinrich , Rahadi Raden Aswin
Published: December 2024

Red mud is a byproduct of Bayer process in alumina refinery which become a major problem in the industry. The waste causes alumina refinery to spend significant amount of capital and operational expenditure to handle and was historically have caused environmental damage to its surrounding environment. To fill the research gap, this work is design to define the cost and benefit of producing geopolymer brick based of red mud by using the Cost Benefit Analysis framework. The cost is determined by the capital and operational expenditure of constructing a geopolymer brick factory and benefit was determine by the amount of cashflow the factory would generate. The work is done in PT CBJ, a new alumina refinery based at Mempawah, West Kalimantan, Indonesia which in the future will produces approximately 30 million tons of red mud. The research showed the proposed project will potentially generating a positive present value cashflow worth $126,159,703.58 from processing an annual 1.5 million ton of red mud and $901,318.85 from 6,892 ton of red mud annual processing. However, the BCR only shows 1.02 and 1.03 ratio from both scenarios. Additionally, the sensitivity analysis shows some variables are way too sensitive after price changes which conclude the project is risky to execute.
Maymun Çiçeği Virüsünün Acil Durum Yönetimi Açısından Değerlendirilmesi
Authors: Usta Galip
Published: December 2024

Geçmişten günümüze birçok salgın olayının yaşandığı ve bu salgınların toplum üzerinde çeşitli etkilerinin olduğu bilinmektedir. Yapılan bu çalışmada Mayıs 2022 tarihinden itibaren görülmeye başlayan maymun çiçeği virüsüne ilişkin vaka durumlarının ve konuya ilişkin toplumsal eğilimlerin belirlenmesi hedeflenmiştir. Çalışmada verilerinin elde edildiği tarihe kadar en fazla vaka bildiren ülkenin Amerika Birleşik Devletleri, en fazla tweet atılan zamanın 21:00-21:59 saatleri arası, en fazla tweet atılan günün perşembe olduğu tespit edilmiştir. Atılan tweetlerin %43,5’nin nötr ve %32,4’ünün kısmen pozitif içerikli olduğu saptanmıştır. Sonuç olarak 2022 yılında tekrardan kendisini gösteren maymun çiçeği virüsünün bir tehdit olarak algılanmasının ve gerekli tedbirlerin alınmasının yerinde olacağı söylenebilir. Kullanıcıların en fazla tweet attığı dönemlerin tespit edilmesi, yetkililer tarafından yapılacak uyarı mesajlarının zamanlaması ve etkileşim yönünden yönetilmesi açısından değerli olabilir. Eğitim faaliyetleri ve yetkililer tarafından düzenli bilgi aktarımı, hastalığın yönetimi ve kontrolü için kritik öneme sahiptir. Bu tür salgın olaylarında, ilgili kurum ve kuruluşların, sivil toplum kuruluşlarının ve toplumun iş birliği içinde hareket etmesi ve toplumsal yönetim stratejilerinin uygulanması, yaşanan durumlarla başa çıkmada önemlidir.
On the Higher-Rank Askey-Wilson Algebras
Authors:   Beijing University of Technology, P.R. China, Wang Wanxia , Yang Shilin ,   Beijing University of Technology, P.R. China
Published: December 2024

In the paper, the algebra $\mathscr{A}(n)$, which is generated by an upper triangular generating matrix with triple relations, is introduced.It is shown that there exists an isomorphism between the algebra $\mathscr{A}(n)$ and the higher-rank Askey-Wilson algebra $\mathfrak{aw}(n)$ introduced by Crampé et al. Furthermore, we establish a series of automorphisms of $\mathscr{A}(n)$, which satisfy braid group relations and coincide with those in $\mathfrak{aw}(n)$.
Legal Privacy Protection Machine Learning Method Based on Word2Vec Algorithm
Authors: Wang Rongrong
Published: December 2024

This study uses Word2Vec's word vector representation technology to finely capture the semantic relationships of vocabulary in legal texts through the Skip-gram model. By introducing Hierarchical Softmax optimization, a legal privacy protection model based on Word2Vec algorithm is ultimately designed. The results showed that the model performed better than other comparative algorithms in both the macro classification performance (Fl_macro) and the micro classification performance (Fl_micro). In practical legal sensitive word recognition tasks, the accuracy, recall rate, and F1 score of the model reached 92.56%, 88.78%, and 90.62%, respectively. Therefore, the proposed model effectively improved the accuracy of identifying sensitive legal privacy words and providing new methods for the personal information security protection system.
The clinical utility of circulating tumor DNA in colorectal cancer: A narrative review
Authors: Lakshmi VU , Rakesh MP , Narmadha MP , Sudhindran S , Balakrishnan D , Koyakutty M
Published: December 2024

Circulating free DNA (cfDNA) refers to extracellular DNA fragments (50-200 base pairs) in the blood, released during cell apoptosis or necrosis, and linked to tissue injury. Microbial cfDNA (cfmDNA), derived from bacteria, can also be present in both healthy individuals and in patients with colorectal cancer, with some species specific to these categories. Circulating tumor DNA (ctDNA), a subset of cfDNA, originates from tumors and reflects their genetic profile. Elevated ctDNA levels result from increased cell death and impaired clearance during tumor progression. Healthy individuals typically have 30 ng/mL of cfDNA in their blood, whereas patients with cancer can show levels up to 1000 ng/mL. Patients with colon cancer often exhibit higher cfDNA concentrations (500 ng/mL) compared to the patients with rectal cancer (250 ng/mL). ctDNA is a valuable noninvasive biomarker for monitoring colorectal cancer progression and prognosis, particularly since the disease is often diagnosed at advanced stages. Its widespread dispersion of circulating tumor fragments also aids in tracking disease progression and recurrence. This article reviews the life cycle, analysis methods, screening approaches, clinical applications, limitations, and future perspectives of ctDNA. The data for this review were extracted from PubMed, ScienceDirect, ResearchGate, Scopus, and UpToDate, covering publications from January 2016 to December 2023. Out of 95 retrieved articles, 3 were removed before screening. Two were duplicates, and 1 was ineligible record. After reviewing 92 articles for eligibility, 7 were excluded: 3 for being non-human studies, 2 not exclusive to colorectal cancer, and 2 for lacking clinical utility. We selected 85 articles for final analysis. For the purpose of discussion, we have referred to various papers on circulating tumor DNA in colorectal cancer as well (n = 15).
Gut microbiota - A key player in breast cancer initiation and progression: A narrative review
Authors: Mohamed Nouran , Madyan Engy F , Yasser Ahmed , Attia Manar G , Abdel-Ghany Shaimaa , Sabit Hussein
Published: December 2024

As the most common type of cancer, breast cancer accounts for 12.5% of all new cases diagnosed each year worldwide. The human gut houses nearly 100 trillion bacteria that have evolved alongside humans over thousands of years. Because of its crucial roles in tumor behavior and treatment response, evaluating the tumor microenvironment in breast cancer is essential for disease management. In recent years, growing evidence has shown that the gut microbiota can influence how cancer cells behave, thereby affecting treatment outcomes. Furthermore, certain gut microbial species can increase the risk of breast cancer by altering estrogen hormone recycling, host metabolism, and immune response. Therefore, manipulating commensal bacteria could serve as a new therapeutic strategy to combat the disease. In this review, we address the mechanistic actions of gut microbiota and their impact on the initiation, progression, and control of breast cancer. We searched for articles published between January 2010 and July 2023 across various databases, including PubMed, Scopus, Google Scholar, and ResearchGate. Specific keywords related to breast cancer, gut bacteria, and the connection between the two were utilized in our search. Clinical trials, as well as in vitro and in vivo investigations, were included, while review articles (including systematic reviews) and studies on cancer other than breast cancer were excluded. We found 165 pertinent papers after filtering 683 articles in preparation for this manuscript.
Predictors of extra nodal extension in oral squamous cell carcinoma: A retrospective analysis
Authors: Majumdar Kinjal Shankar , Kailey Vikramjit Singh , Abhinav Thaduri , Panuganti Achyuth , Bhardwaj Abhishek , Sahu Madhupriya , Malhotra Manu
Published: December 2024

Background:

Extranodal extension (ENE) has emerged as the strongest predictor of recurrence in oral squamous cell carcinoma (OSCC) and the only operator-independent predictor of treatment intensification in the form of adjuvant chemoradiation.

Objectives:

The primary objective was to identify various clinical and pathological predictors of pathological ENE (pENE) in surgically resected OSCC, and the secondary objective was to determine accuracy of clinical ENE (cENE) in predicting pathological ENE (pENE).

Materials and Methods:

In this retrospective analysis, we included all biopsy proven patients with OSCC who underwent surgery with appropriate neck dissection from April 2018 - December 2022 at the Department of Otolaryngology-Head-and-Neck Surgery, All India Institute of Medical Sciences Rishikesh, India. Tumors were staged according to the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) 8th edition tumor, node and metastasis (TNM) classification. Clinical and pathological variables were subjected to univariate and multivariate analyses.

Results:

We enrolled 299 patients in this study. Pathological bone invasion (BI), presence of perineural invasion (PNI), total number of positive lymph nodes, and lymph node ratio (LNR) were found to be independent predictors of pENE in both univariate and multivariate analyses. Post hoc analysis showed that ≥ 5 positive lymph nodes and LNR of ≥ 0.1 were significantly associated with pENE. Clinical ENE (cENE) exhibited a high specificity (92.9%) and negative predictive value (89.4%) for pENE.

Conclusion:

Clinical tumor characteristics are poor predictors of pENE. BI, PNI, and pathological nodal parameters, namely, total number of positive nodes and lymph node ratio, are the major predictors of pENE.
Prevalence and risk factors of oral premalignant lesions through visual screening among security personnel working at a tertiary care hospital: A descriptive cross-sectional study
Authors: Sreeja C S , Priya Harsh , Gopichandran L , Salve Harshal R , Dahiya Ujjwal , Ravi Priyanka , Agarwal Deepali
Published: December 2024

Background:

Oral cancer is often preceded by oral premalignant lesions. However, most patients present at advanced stages, leading to poor quality of life (QOL).

Objectives:

The primary objective was to assess risk factors and prevalence of oral cancer among security personnel. The secondary objective focused on studying the relationship of selected risk factors with oral cancer and correlating them with prevalence.

Materials and Methods:

A descriptive cross-sectional study was conducted from June - November 2019 on 255 security personnel at AIIMS, New Delhi. Risk exposure was assessed using the WHO STEPwise Approach to Surveillance (STEPS) instrument. Visual examinations were performed using a light source and tongue depressor. Data analysis included descriptive and inferential statistics to determine frequencies, percentages, means, and standard deviations. Chi-square, Fisher’s exact tests, and logistic regression were used to assess associations and risks, with significance set at P ≤ 0.05.

Results:

We included 255 participants in the study. The overall prevalence of premalignant lesions was 29% (n = 74). Among subjects, 15.7% (n = 40) were smokers, and 33.3% (n = 85) used smokeless tobacco. Significant associations were observed for smoking (P, 0.002), smokeless tobacco use (P < 0.001), frequency of smokeless tobacco use (P, 0.041), alcohol and smokeless tobacco combination (P < 0.001), and dental visit frequency (P, 0.023). Binary logistic regression showed smokeless tobacco (Odds ratio, OR, 25.96, P < 0.001) and smoking (OR, 2.98, P, 0.020) as significant risk factors.

Conclusion:

Visual screening is a simple and cost-effective method for early detection of oral cancer. Visual screening along with tobacco cessation can help reduce the incidence of oral cancer and improve outcomes.
Effect of Knee Brace on Patterns of Weight Distribution in Patients with Stroke: A Cross-Sectional Study
Authors: Arunkumar Mishra Simran , Harishchandre Maheshwari , Shyam Ganvir Suvarna
Published: December 2024

Background:

Impaired postural control is a key characteristic of mobility issues in patients with stroke. It increases the risk of falls. Weight-bearing asymmetry (WBA) is found associated with balance, which is considered one of the determinants for the prediction of post-stroke functional outcomes. However, limited data are available regarding patterns of weight distribution in stroke patients and if the provision of orthosis changes this pattern.

Aim:

This study aimed to assess the effect of knee brace on patterns of weight distribution in stroke patients.

Materials and Methods:

It is a cross-sectional study, in which 46 patients with stroke having genu recurvatum were included. BOBO PRO, a balance platform was used to assess patterns of weight distribution. Patients were asked to stand on a balance platform, and readings were recorded during double- and single-leg stances, without and with a knee brace.

Results:

During the double-leg stance, without a knee brace, more weight was on the unaffected side (75%–80%), of which 55%–60 % was on the hindfoot and 20%–25% on the forefoot. On the affected side, weight-bearing was reduced, (20%–25%); of which maximum weight was on the hindfoot (17%–18 %) and minimal weight was on the forefoot (2%–3 %). With a Knee brace weight distribution on the affected side was improved to 35 % (24%–25 % on the hindfoot and 10%–11 % on the forefoot). During single-leg stance without a knee brace, 84%–90 % of the weight was on the hindfoot, which changed to 70%–75 % with the application of a brace.

Conclusion:

The knee brace affects patterns of weight distribution in stroke patients. This indicates that the provision of a knee brace in the rehabilitation of post-stroke patients may lead to better rehabilitation outcomes.
Pharmacognostic profiling, antioxidant, and anticancer potential of Mimusops elengi and Cassia tora extracts
Authors: Dixit Priyanka , Singh Deepika , Singh Narendra Kumar , Gupta Rajiv
Published: December 2024

Background:

Important Ayurvedic medicinal plants Mimusops elengi L. and Cassia tora L. (CT). have been mentioned and used in the traditional Indian system of medicine for the prophylaxis and treatment of various human ailments.

Aim:

To evaluate the pharmacognostic, chromatographic, antioxidant, and anticancer properties of ethanolic leaf extracts from ME and CT on scientific lines and thereby validate the claims of traditional text.

Materials and Methods:

Chromatographic characterization was performed using high-performance thin-layer chromatography. 2,2-diphenyl-1-picrylhydrazyl assay was performed to evaluate the antioxidant activity. Sulforhodamine B and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were performed to evaluate anticancer activity on Hop-62, Colo-205, breast cancer cell line (MCF-7), HeLa, and HepG2 cancer cells. Apoptosis was studied through live/dead cellular viability and apoptotic assay.

Results:

The pharmacognostic parameters were obtained to aid in the accurate authentication and identification of ME and CT. Chromatographic analysis revealed the presence of gallic acid, Quercetin, and ursolic acid. The study demonstrated concentration-dependent antioxidant and anticancer activities. Notably, selected extracts exhibited the highest cytotoxicity against MCF-7 cancer cells and the activity might be produced by inducing apoptosis. The extract of ME showed promising results across all selected cancer cell lines compared to CT.

Conclusion:

Further studies are hereby being recommended, particularly related to the exact mechanism of anticancer action, along with the isolation of leads responsible for the activity, to fully explore the anticancer potential of these plants.
A theoretical framework for integration of technology with fundamental principles of Ayurveda to develop a prototype instrument to assess Guna (viz. Gurvadi guna)
Authors: Ram Niranjan , Athul T. P. , Deogade Meena , Nesari Tanuja Manoj
Published: December 2024

Background:

The foremost challenge for global acceptance of traditional systems of Indian medicine is to establish evidence for all the documentation mentioned in the texts. To make Ayurveda more evidence-based, there is a need for an abundance of data with proper validity and reliability. To ensure that the data collected from various research studies is reliable as well as valid, there is a need to convert possible subjective parameters into objective ones. Guna (~attribute/property), a fundamental concept in Ayurveda, particularly Gurvadi guna (~physical attributes), is a similar subjective parameter that needs more objectivity to be assessed uniformly by all practitioners of Ayurveda.

Aim:

The aim of this study was to propose a conceptual framework for developing a prototype instrument that objectively assesses Gurvadi guna in both substances and the human body, integrating technology with Ayurvedic principles.

Methods:

This concept presents a theoretical framework, synthesizing ideas from Ayurvedic philosophy, modern scientific techniques, and technological innovations. It proposes the integration of chromatography, spectroscopy, biophysical techniques, and nanotechnology for Guna assessment. The framework envisages a multifunctional instrument capable of evaluating Gurvadi guna in substances and human physiology simultaneously.

Expected Outcomes:

The proposed instrument targets to provide a standardized approach to Guna assessment in Ayurvedic practice, objective measurements of Gurvadi guna in various substances and the human body, and enhanced precision in diagnosing imbalances and selecting appropriate treatments.

Conclusion:

This conceptual framework represents a novel approach to bridging traditional Ayurvedic knowledge with modern technology. While acknowledging the challenges in development and implementation, this proposal aims to stimulate interdisciplinary collaboration and innovation in Ayurvedic research and practice.