bluuebunny/crossref_metadata_2025 huggingface dataset:
Spinal Cord Motion in Degenerative Cervical Myelopathy: The Level of the Stenotic Segment and Gender Cause Altered Pathodynamics
Authors: Wolf Katharina , Reisert Marco , Beltrán Saúl Felipe , Klingler Jan-Helge , Hubbe Ulrich , Krafft Axel J. , Kremers Nico , Egger Karl , Hohenhaus Marc
Published: August 2021

In degenerative cervical myelopathy (DCM), focally increased spinal cord motion has been observed for C5/C6, but whether stenoses at other cervical segments lead to similar pathodynamics and how severity of stenosis, age, and gender affect them is still unclear. We report a prospective matched-pair controlled trial on 65 DCM patients. A high-resolution 3D T2 sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) and a phase-contrast magnetic resonance imaging (MRI) sequence were performed and automatically segmented. Anatomical and spinal cord motion data were assessed per segment from C2/C3 to C7/T1. Spinal cord motion was focally increased at a level of stenosis among patients with stenosis at C4/C5 (n = 14), C5/C6 (n = 33), and C6/C7 (n = 10) (p < 0.033). Patients with stenosis at C2/C3 (n = 2) and C3/C4 (n = 6) presented a similar pattern, not reaching significance. Gender was a significant predictor of higher spinal cord dynamics among men with stenosis at C5/C6 (p = 0.048) and C6/C7 (p = 0.033). Age and severity of stenosis did not relate to spinal cord motion. Thus, the data demonstrates focally increased spinal cord motion depending on the specific level of stenosis. Gender-related effects lead to dynamic alterations among men with stenosis at C5/C6 and C6/C7. The missing relation of motion to severity of stenosis underlines a possible additive diagnostic value of spinal cord motion analysis in DCM.
Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia
Authors: Iacobucci Ilaria , Kimura Shunsuke , Mullighan Charles G.
Published: August 2021

Acute lymphoblastic leukemia (ALL) is the most successful paradigm of how risk-adapted therapy and detailed understanding of the genetic alterations driving leukemogenesis and therapeutic response may dramatically improve treatment outcomes, with cure rates now exceeding 90% in children. However, ALL still represents a leading cause of cancer-related death in the young, and the outcome for older adolescents and young adults with ALL remains poor. In the past decade, next generation sequencing has enabled critical advances in our understanding of leukemogenesis. These include the identification of risk-associated ALL subtypes (e.g., those with rearrangements of MEF2D, DUX4, NUTM1, ZNF384 and BCL11B; the PAX5 P80R and IKZF1 N159Y mutations; and genomic phenocopies such as Ph-like ALL) and the genomic basis of disease evolution. These advances have been complemented by the development of novel therapeutic approaches, including those that are of mutation-specific, such as tyrosine kinase inhibitors, and those that are mutation-agnostic, including antibody and cellular immunotherapies, and protein degradation strategies such as proteolysis-targeting chimeras. Herein, we review the genetic taxonomy of ALL with a focus on clinical implications and the implementation of genomic diagnostic approaches.
Experimental Study of Large-Temperature-Range and Long-Period Monitoring for LNG Marine Auxiliary Based on Fiber Bragg Grating Temperature Measurement
Authors: Han Fenghui , Wang Zhe , Zhang Hefu , Wang Dongxing , Li Wenhua , Cai Wenjian
Published: August 2021

Temperature is a key variable to evaluate the energy consumption and thermodynamic performance of traditional marine auxiliary machinery, chillers and piping systems. In particular, for the cryogenic storage tanks and fuel gas supply systems of LNG ships, explosion-proof and low-temperature-resistance properties bring new challenges to the onboard temperature measurement and monitoring. In order to promote the development of high-performance and safer monitoring systems for LNG ships, this paper adopted fiber Bragg grating (FBG) technology to ensure the measurement safety and accuracy of temperature sensors, and performs a series of experiments in a large temperature range on the chiller, pipeline, and cryogenic storage tank of an LNG ship and their long-term reliabilities. Firstly, the principle and composition of the designed FBG temperature sensors are introduced in detail, and the measurement accuracy and range of different metal-coated optical fibers were tested in a large temperature range and compared against the traditional thermistors. Then, the effects of different operating conditions of the LNG marine chiller system and cryogenic storage tank on the temperature measurements were investigated. In addition, the drift degrees of the optical fibers and industrial thermistors were analyzed to figure out their reliabilities for long-term temperature measurements. The results showed that for the long-period (16 months) monitoring of LNG ships in a large temperature range (105–315 K) under different shipping conditions, the optical temperature measurement based on FBG technology has sufficient accuracy and dynamic sensitivity with a higher safety than the traditional thermoelectric measurement. Besides, the ship vibration, ambient humidity, and great temperature changes have little impact on its measurement reliability and drifts. This research can provide references and technical supports to the performance testing systems of LNG ships and other relevant vessels with stricter safety standards.
CICE-LETKF Ensemble Analysis System with Application to Arctic Sea Ice Initialization
Authors: Liu Xiying , Sha Zicheng , Lu Chenchen
Published: August 2021

To study the effectiveness of methods to reduce errors for Arctic Sea ice initialization due to underestimation of background error covariance, an advanced ensemble analysis system has been developed. The system integrates the local ensemble transform Kalman filter (LETKF) with the community ice code (CICE). With a mixed layer ocean model used to compute the sea surface temperature (SST), the experiments on assimilation of observations of sea ice concentration (SIC) have been carried out. Assimilation experiments were performed over a 3-month period from January to March in 1997. The model was sequentially constrained with daily observation data. The effects of observation density, amplification factor for analysis error covariance, and relaxation of disturbance and spread on the results of SIC initialization were studied. It is shown that doubling the density of observation of SIC does not bring significant further improvement on the analysis result; when the ensemble size is doubled, most severe SIC biases in the Labrador, Greenland, Norwegian, and Barents seas are reduced; amplifying the analysis error covariance, relaxing disturbance, and relaxing spread all contribute to improving the reproduction of SIC with amplifying covariance with the largest magnitude.
Identification of Substances Produced by Cercospora brachiata in Absence of Light and Evaluation of Antibacterial Activity
Authors: Felisbino John K. R. P. , Vieira Bruno S. , de Oliveira Alberto , da Silva Neiliane A. , Martins Carlos H. G. , Santiago Mariana B. , Munoz Rodrigo A. A. , Cunha Luís C. S. , Sousa Raquel M. F.
Published: August 2021

Cercospora brachiata is a phytopathogenic fungus. To know more about the metabolites produced by this fungus, the objective of this work was to identify, isolate and characterize substances present in extracts of the growth broth and mycelium, using gas chromatography with mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). It was also objective to evaluate the antibacterial activity of the extracts. Among the compounds identified, fatty acids, esters, and steroids can be highlighted. The main compounds identified are 9-hexadecenoic, hexadecenoic, oleic, octadecanoic, lauric, myristic, palmitic, doceno-13-enoic, stearic, linoleic, and nonadecanoic acids present in almost all extracts. For the antibacterial activity, the broth microdilution method was used. The ethyl acetate extract of the mycelium presented inhibitory concentrations (MICs) against the bacterium Actinomyces naeslundii (100 μg mL−1) and Streptococcus sanguinis (200 μg mL−1). Finally, two steroids were isolated and identified in the hexane extract of mycelium: ergosta-6,22-dien-3β,5α,8α-triol and brassicasterol.
An Outbreak of Trichophyton quinckeanum Zoonotic Infections in the Czech Republic Transmitted from Cats and Dogs
Authors: Lysková Pavlína , Dobiáš Radim , Čmoková Adéla , Kolařík Miroslav , Hamal Petr , Šmatláková Kateřina , Hušek Jan , Mencl Karel , Mallátová Nad’a , Poláčková Zora , Krnáčová Anežka , Palkovičová Kristýna , Jablonská Daniela , Macháčová Jitka , Drlík Zdeněk , Bázsóová Denisa , Jaworská Pavla , Svobodová Lucie , Hubka Vit
Published: August 2021

Trichophyton quinckeanum, a zoophilic dermatophyte mostly known as the causative agent of rodent favus, is relatively rarely reported to cause human infections. Indeed, no infections were detected in Czechia between 2012 and 2015 despite routine verification of species identification by ITS rDNA sequencing. By contrast, 25 human and 11 animal cases of infection were documented from December 2016 to December 2020 and the rates tended to grow every following year. Interestingly, most of the cases were reported in the Olomouc region, suggesting a local outbreak. We bring the evidence that human T. quinckeanum infections are most commonly contracted from infected cats or, less frequently, dogs. Although rodents or contaminated soil and environment could be the source of infection to cats and dogs, the occurrence of infections in multiple animals in the same household suggests direct transmission among animals. Confirmation of the identification by molecular methods is highly recommended due to morphological similarity with T. mentagrophytes/T. interdigitale. Antifungal susceptibility testing of isolates to eight antifungals was performed using EUCAST methodology (E.Def 11.0). Among the tested antifungals, terbinafine, amorolfine, ciclopirox and efinaconazole were most potent in vitro and elevated minimum inhibitory concentrations were obtained for fluconazole and ketoconazole.
α4β1 and αMβ2 Integrin Expression and Pro-Proliferative Properties of Eosinophil Subtypes in Asthma
Authors: Jurkeviciute Egle , Januskevicius Andrius , Rimkunas Airidas , Palacionyte Jolita , Malakauskas Kestutis
Published: August 2021

Eosinophilic inflammation is one of the main pathophysiological features in asthma. Two subtypes of eosinophils exist in the lung and systemic circulation: lung-resident eosinophils (rEOS) and inflammatory eosinophils (iEOS). We evaluated the expression of α4β1 and αMβ2 integrins of eosinophil subtypes and their influence on airway smooth muscle (ASM) cell proliferation and viability in asthma. We included 16 severe non-allergic eosinophilic asthma (SNEA) patients, 13 steroid-free, non-severe allergic asthma (AA) patients, and 12 healthy control subjects (HS). For AA patients, a bronchial allergen challenge with Dermatophagoides pteronyssinus was performed. The eosinophil subtypes were distinguished using magnetic bead-labeled antibodies against surface CD62L, and individual combined cell cultures were prepared with ASM cells. The integrins gene expression was analyzed by a quantitative real-time polymerase chain reaction. Proliferation was assessed by the Alamar blue assay, and viability by annexin V and propidium iodide staining. rEOS-like cells were characterized by the relatively higher gene expression of the β1 integrin subunit, whereas iEOS-like cells were characterized by the αM and β2 integrin subunits. The inclusion of either eosinophil subtypes in co-culture significantly increased the proliferation of ASM cells, and the effect of rEOS-like cells was stronger than iEOS-like cells (p < 0.05). Furthermore, rEOS-like cells had a more pronounced effect on reducing ASM cell apoptosis compared to that of iEOS-like cells (p < 0.05). Lastly, the bronchial allergen challenge significantly enhanced only the iEOS-like cells’ effect on ASM cell proliferation and viability in AA patients (p < 0.05). These findings highlight the different expression of α4β1 and αMβ2 integrins on distinct eosinophil subtypes in asthma. Therefore, rEOS-like cells have a stronger effect in stimulating ASM cell proliferation and viability; however, contact with specific allergens mainly enhances pro-proliferative iEOS-like cell properties.
Differences in the Content of Zn Fractions in the Profiles of Soils from Allotment and Domestic Gardens in South-Eastern Poland
Authors: Makuch-Pietraś Iwona , Wójcikowska-Kapusta Anna
Published: August 2021

The aim of the research was to show the distribution of fractions as well as bioavailability and the total forms of Zn in the profiles of soils from domestic gardens and family allotment gardens in six cities in south-eastern Poland. Results found that the level of Zn total form varied in the ranges from A horizon: 12.75–154.75 mg·kg−1 in sandy soils and 18.20–104.00 mg·kg−1 in silty soils. Accumulation of metals was assessed using concentration indices, Igeo, and the Cav/Ct and BF indices of bioavailable forms. The analysis took into account the role of organic matter as an important component in binding the analyzed metals in soil horizons subjected to long-term horticultural cultivation. In the two groups of sandy and silty soils distinguished according to their particle size distribution, horticultural treatments were found to exert a greater impact on sandy soils. Additionally, higher contents of the examined element were stated in the humus horizons, as indicated by the high values of concentration and Igeo indices showing high Zn pollution in the soils. The content of bioavailable zinc forms was significantly high, especially in soils with a higher metal content.
The Demsetz’s Evolutionary Theory of Property Rights as Applied to Rural Land of China: A Supplement
Authors: Zhang Yanlong
Published: August 2021

The main objective of this article is to contribute to the literature on land issues, especially with regard to the evolutionary theory of China’s rural land property rights. This article applies the Demsetz’s evolutionary theory of property rights as a framework into an analysis of the evolutionary process of property rights in rural land of China. It is found that externality, compactness, productivity, and organizational complexity—four principles in Demsetz’s framework—are at the core of understanding the evolution of property rights from collective control of land to family based control of land in China. However, the framework is incomplete due to being unlikely to notice the role of land titling so that a property rights game is developed in this article to extend the evolutionary theory of property rights. Importantly, it suggests the necessity of “split-rights” from family based control land to private control land in China. To sum up, this paper refreshes the dominant framework of analysis on the evolution of property rights in mainstream economics, and makes it discern when collective ownership does not evolve into pure privatization, finally, instead of into private control of land, as is currently applied to rural area in China.
Efficacy of Bacterial Nanocellulose in Hard Tissue Regeneration: A Review
Authors: Kumar Anuj , Han Sung-Soo
Published: August 2021

Bacterial nanocellulose (BNC, as exopolysaccharide) synthesized by some specific bacteria strains is a fascinating biopolymer composed of the three-dimensional pure cellulosic nanofibrous matrix without containing lignin, hemicellulose, pectin, and other impurities as in plant-based cellulose. Due to its excellent biocompatibility (in vitro and in vivo), high water-holding capacity, flexibility, high mechanical properties, and a large number of hydroxyl groups that are most similar characteristics of native tissues, BNC has shown great potential in tissue engineering applications. This review focuses on and discusses the efficacy of BNC- or BNC-based biomaterials for hard tissue regeneration. In this review, we provide brief information on the key aspects of synthesis and properties of BNC, including solubility, biodegradability, thermal stability, antimicrobial ability, toxicity, and cellular response. Further, modification approaches are discussed briefly to improve the properties of BNC or BNC-based structures. In addition, various biomaterials by using BNC (as sacrificial template or matrix) or BNC in conjugation with polymers and/or fillers are reviewed and discussed for dental and bone tissue engineering applications. Moreover, the conclusion with perspective for future research directions of using BNC for hard tissue regeneration is briefly discussed.
Waste Wood Particles from Primary Wood Processing as a Filler of Insulation PUR Foams
Authors: Mirski Radosław , Dukarska Dorota , Walkiewicz Joanna , Derkowski Adam
Published: August 2021

A significant part of the work carried out so far in the field of production of biocomposite polyurethane foams (PUR) with the use of various types of lignocellulosic fillers mainly concerns rigid PUR foams with a closed-cell structure. In this work, the possibility of using waste wood particles (WP) from primary wood processing as a filler for PUR foams with open-cell structure was investigated. For this purpose, a wood particle fraction of 0.315–1.25 mm was added to the foam in concentrations of 0, 5, 10, 15 and 20%. The foaming course of the modified PUR foams (PUR-WP) was characterized on the basis of the duration of the process’ successive stages at the maximum foaming temperature. In order to explain the observed phenomena, a cellular structure was characterized using microscopic analysis such as SEM and light microscope. Computed tomography was also applied to determine the distribution of wood particles in PUR-WP materials. It was observed that the addition of WP to the open-cell PUR foam influences the kinetics of the foaming process of the PUR-WP composition and their morphology, density, compressive strength and thermal properties. The performed tests showed that the addition of WP at an the amount of 10% leads to the increase in the PUR foam’s compressive strength by 30% (parallel to foam’s growth direction) and reduce the thermal conductivity coefficient by 10%.
High-Performance HVOF-Sprayed Fe-Based Amorphous Coating on LA141 Magnesium Alloy via Optimizing Oxygen Flow and Kerosene Flow
Authors: Sun Yijiao , Wang Weichao , Li Hongxiang , Xie Lu , Li Yongbing , Wang Shanlin , Wang Wenrui , Zhang Jiaming , Zhang Jishan
Published: August 2021

To solve the problem of poor corrosion and wear resistance of Mg-Li alloys, Fe-based amorphous coatings were prepared by high velocity oxygen-fuel spraying technology (HVOF) on the LA141 magnesium alloy substrate with a Ni60 intermediate layer. The microstructure and performance of Fe-based amorphous coatings with different oxygen flow and kerosene flow were characterized and analyzed. The results demonstrate that there is an optimal oxygen/kerosene ratio where the porosity of Fe-based amorphous coating is the lowest. Moreover, the amorphous content increases with the decrease in the oxygen/kerosene ratio. In particular, when the oxygen flow is 53.8 m3/h and the kerosene flow is 26.5 L/h, the Fe-based amorphous coating possesses the lowest porosity (0.87%), the highest hardness (801 HV0.1), the highest bonding strength (56.9 MPa), and an excellent corrosion and wear resistance. Additionally, it can be seen that the Fe-based amorphous coating is composed of amorphous splats and amorphous oxides, but the Ni60 intermediate layer exhibits an amorphous and crystalline multi-phase structure. The high bonding strength of the coating is attributed to the low porosity of Fe-based amorphous coating and the localized metallurgical bonding between different layers. Finally, the mechanisms on corrosion and wear of Fe-based amorphous coatings are also discussed.
A Geometry-Based Welding Distortion Prediction Tool
Authors: Granell Ignacio , Ramos Abel , Carnicero Alberto
Published: August 2021

The prediction of welding distortion requires expertise in computer simulation programs, a clear definition of the nonlinear material properties, and mesh settings together with the nonlinear solution settings of a coupled thermal–structural analysis. The purpose of this paper is to present the validation of an automatic simulation tool implemented in Ansys using Python scripting. This tool allows users to automate the preparation of the simulation model with a reduced number of inputs. The goal was, based on some assumptions, to provide an automated simulation setup that enables users to predict accurate distortion during the welding manufacturing process. Any geometry prepared in a CAD software can be used as the input, which gave us much geometrical flexibility in the shapes and sizes to be modeled. A thermomechanical loosely coupled analysis approach together with element birth and death technology was used to predict the distortions. The automation of the setup enables both simulation and manufacturing engineers to perform welding-induced distortion prediction. The results showed that the method proposed predicts distortion with 80–98% accuracy.
A Versatile Punch Stroke Correction Model for Trial V-Bending of Sheet Metals Based on Data-Driven Method
Authors: Yu Yongsen , Guan Zhiping , Ren Mingwen , Song Jiawang , Ma Pinkui , Jia Hongjie
Published: August 2021

During air bending of sheet metals, the correction of punch stroke for springback control is always implemented through repeated trial bending until achieving the forming accuracy of bending parts. In this study, a modelling method for correction of punch stroke is presented for guiding trial bending based on a data-driven technique. Firstly, the big data for the model are mainly generated from a large number of finite element simulations, considering many variables, e.g., material parameters, dimensions of V-dies and blanks, and processing parameters. Based on the big data, two punch stroke correction models are developed via neural network and dimensional analysis, respectively. The analytic comparison shows that the neural network model is more suitable for guiding trial bending of sheet metals than the dimensional analysis model, which has mechanical significance. The actual trial bending tests prove that the neural-network-based punch stroke correction model presents great versatility and accuracy in the guidance of trial bending, leading to a reduction in the number of trial bends and an improvement in the production efficiency of air bending.
Characterization and Hydration Mechanism of Ammonia Soda Residue and Portland Cement Composite Cementitious Material
Authors: Xu Dong , Fu Pingfeng , Ni Wen , Wang Qunhui , Li Keqing
Published: August 2021

The use of ammonia soda residue (ASR) to prepare building materials is an effective way to dispose of ASR on a large scale, but this process suffers from a lack of data and theoretical basis. In this paper, a composite cementitious material was prepared using ASR and cement, and the hydration mechanism of cementitious materials with 5%, 10%, and 20% ASR was studied. The XRD and SEM results showed that the main hydration products of ASR-cement composite cementitious materials were an amorphous C-S-H gel, hexagonal plate-like Ca(OH)2 (CH), and regular hexagonal plate-like Friedel’s salt (FS). The addition of ASR increased the heat of hydration of the cementitious material, which increased upon increasing the ASR content. The addition of ASR also reduced the cumulative pore volume of the hardened paste, which displayed the optimal pore structure when the ASR content was 5%. In addition, ASR shortened the setting time compared with the cement group, and the final setting times of the pastes with 5%, 10%, and 20% ASR were 30 min, 45 min, and 70 min shorter, respectively. When the ASR content did not exceed 10%, the 3-day compressive strength of the mortar was significantly improved, but the 28-day compressive strength was worse. Finally, the hydration mechanism and potential applications of the cementitious material are discussed. The results of this paper promote the use of ASR in building materials to reduce CO2 emissions in the cement industry.
Metallothermic Reduction of MoO3 on Combustion Synthesis of Molybdenum Silicides/MgAl2O4 Composites
Authors: Yeh Chun-Liang , Chen Min-Chia
Published: August 2021

Combustion synthesis involving metallothermic reduction of MoO3 by dual reductants, Mg and Al, to enhance the reaction exothermicity was applied for the in situ production of Mo3Si–, Mo5Si3− and MoSi2–MgAl2O4 composites with a broad compositional range. Reduction of MoO3 by Mg and Al is highly exothermic and produces MgO and Al2O3 as precursors of MgAl2O4. Molybdenum silicides are synthesized from the reactions of Si with both reduced and elemental Mo. Experimental evidence indicated that the reaction proceeded as self-propagating high-temperature synthesis (SHS) and the increase in silicide content weakened the exothermicity of the overall reaction, and therefore, lowered combustion front temperature and velocity. The XRD analysis indicated that Mo3Si–, Mo5Si3– and MoSi2–MgAl2O4 composites were well produced with only trivial amounts of secondary silicides. Based on SEM and EDS examinations, the morphology of synthesized composites exhibited dense and connecting MgAl2O4 crystals and micro-sized silicide particles, which were distributed over or embedded in the large MgAl2O4 crystals.
Assessment of the Technological Quality of X5CRNI18-10 Steel Parts after Laser and Abrasive Water Jet Cutting Using Synthetic Index of Technological Quality
Authors: Romanowski Marcin , Łukianowicz Czesław , Sutowska Marzena , Zawadka Wojciech , Pimenov Danil Yurievich , Nadolny Krzysztof
Published: August 2021

Despite extensive knowledge of the cutting methods described, no universal method has been developed so far for evaluating the technological quality of elements shaped by different cutting processes. The aim of the research described in this article was to fill this gap and to propose the author’s methodology for the assessment of the technological quality of the surface of X5CRNI18-10 steel shaped as a result of laser cutting and abrasive water jet cutting. A synthetic index of technological quality assessment of the surface after cutting CTQ (cutting technological quality) was proposed. Three groups of factors were taken into account in the assessment of technological quality of the surface after cutting: selected surface texture parameters (arithmetic mean deviation of the surface Sa and total height of the surface St), results of measurements of dimensional accuracy of cut elements (length deviation LD and width deviation WD) as well as indicators of surface morphology estimated on the basis of microscopic images of the surface after cutting (deformation intensity DI and identification of cutting zones ICZ). On the basis of CTQ values determined, the cutting results of both cutting methods were compared. The analyses presented in this paper proved that the CTQ index can be effectively used to compare the results of a cutting process conducted using different methods and under different conditions. The developed CTQ index is a universal valuation tool, allowing for quantitative evaluation of features related to the technological quality of cutting process results.
Sintering Temperature, Frequency, and Temperature Dependent Dielectric Properties of Na0.5Sm0.5Cu3Ti4O12 Ceramics
Authors: Kotb Hicham Mahfoz , Khater Hassan A. , Saber Osama , Ahmad Mohamad M.
Published: August 2021

NSCTO (Na0.5Sm0.5Cu3Ti4O12) ceramics have been prepared by reactive sintering solid-state reaction where the powder was prepared from the elemental oxides by mechanochemical milling followed by conventional sintering in the temperature range 1000–1100 °C. The influence of sintering temperature on the structural and dielectric properties was thoroughly studied. X-ray diffraction analysis (XRD) revealed the formation of the cubic NSCTO phase. By using the Williamson–Hall approach, the crystallite size and lattice strain were calculated. Scanning electron microscope (SEM) observations revealed that the grain size of NSCTO ceramics is slightly dependent on the sintering temperature where the average grain size increased from 1.91 ± 0.36 μm to 2.58 ± 0.89 μm with increasing sintering temperature from 1000 °C to 1100 °C. The ceramic sample sintered at 1025 °C showed the best compromise between colossal relative permittivity (ε′ = 1.34 × 103) and low dielectric loss (tanδ = 0.043) values at 1.1 kHz and 300 K. The calculated activation energy for relaxation and conduction of NSCTO highlighted the important role of single and double ionized oxygen vacancies in these processes.
A Study of Treatment of Industrial Acidic Wastewaters with Stainless Steel Slags Using Pilot Trials
Authors: De Colle Mattia , Puthucode Rahul , Karasev Andrey , Jönsson Pär G.
Published: August 2021

Different stainless steel slags have been successfully employed in previous experiments, for the treatment of industrial acidic wastewaters. Although, before this technology can be implemented on an industrial scale, upscaled pilot experiments need to be performed. In this study, the parameters of the upscale trials, such as the volume and mixing speeds, are firstly tested by dispersing a NaCl tracer in a water bath. Mixing time trials are used to maintain constant mixing conditions when the volumes are increased to 70, 80 and 90 L, compared to the 1 L laboratory trials. Subsequently, the parameters obtained are used in pH buffering trials, where stainless steel slags are used as reactants, replicating the methodology of previous studies. Compared to laboratory trials, the study found only a minor loss of efficiency. Specifically, in previous studies, 39 g/L of slag was needed to buffer the pH of the acidic wastewaters. To reach similar pH values within the same time span, upscaled trials found a ratio of 43 g/L and 44 g/L when 70 and 90 L are used, respectively. Therefore, when the kinetic conditions are controlled, the technology appears to be scalable to higher volumes. This is an important finding that hopefully promotes further investments in this technology.
On a Boundary Value Problem for the Biharmonic Equation with Multiple Involutions
Authors: Turmetov Batirkhan , Karachik Valery , Muratbekova Moldir
Published: August 2021

A nonlocal analogue of the biharmonic operator with involution-type transformations was considered. For the corresponding biharmonic equation with involution, we investigated the solvability of boundary value problems with a fractional-order boundary operator having a derivative of the Hadamard-type. First, transformations of the involution type were considered. The properties of the matrices of these transformations were investigated. As applications of the considered transformations, the questions about the solvability of a boundary value problem for a nonlocal biharmonic equation were studied. Modified Hadamard derivatives were considered as the boundary operator. The considered problems covered the Dirichlet and Neumann-type boundary conditions. Theorems on the existence and uniqueness of solutions to the studied problems were proven.
Noncanonical Neutral DDEs of Second-Order: New Sufficient Conditions for Oscillation
Authors: Hindi Awatif A. , Moaaz Osama , Cesarano Clemente , Alharbi Wedad R. , Abdou Mohamed A.
Published: August 2021

In this paper, new oscillation conditions for the 2nd-order noncanonical neutral differential equation (a0t((ut+a1tug0t)′)β)′+a2tuβg1t=0, where t≥t0, are established. Using Riccati substitution and comparison with an equation of the first-order, we obtain criteria that ensure the oscillation of the studied equation. Furthermore, we complement and improve the previous results in the literature.
On the Embed and Project Algorithm for the Graph Bandwidth Problem
Authors: Povh Janez
Published: August 2021

The graph bandwidth problem, where one looks for a labeling of graph vertices that gives the minimum difference between the labels over all edges, is a classical NP-hard problem that has drawn a lot of attention in recent decades. In this paper, we focus on the so-called Embed and Project Algorithm (EPA) introduced by Blum et al. in 2000, which in the main part has to solve a semidefinite programming relaxation with exponentially many linear constraints. We present several theoretical properties of this special semidefinite programming problem (SDP) and a cutting-plane-like algorithm to solve it, which works very efficiently in combination with interior-point methods or with the bundle method. Extensive numerical results demonstrate that this algorithm, which has only been studied theoretically so far, in practice gives very good labeling for graphs with n≤1000.
OpenCNN: A Winograd Minimal Filtering Algorithm Implementation in CUDA
Authors: Castro Roberto L. , Andrade Diego , Fraguela Basilio B.
Published: August 2021

Improving the performance of the convolution operation has become a key target for High Performance Computing (HPC) developers due to its prevalence in deep learning applied mainly to video processing. The improvement is being pushed by algorithmic and implementation innovations. Algorithmically, the convolution can be solved as it is mathematically enunciated, but other methods allow to transform it into a Fast Fourier Transform (FFT) or a GEneral Matrix Multiplication (GEMM). In this latter group, the Winograd algorithm is a state-of-the-art variant that is specially suitable for smaller convolutions. In this paper, we present openCNN, an optimized CUDA C++ implementation of the Winograd convolution algorithm. Our approach achieves speedups of up to 1.76× on Turing RTX 2080Ti and up to 1.85× on Ampere RTX 3090 with respect to Winograd convolution in cuDNN 8.2.0. OpenCNN is released as open-source software.
A Proportional-Egalitarian Allocation Policy for Public Goods Problems with Complex Network
Authors: Zhang Guang , He Nan , Dong Yanxia
Published: August 2021

How free-riding behavior can be avoided is a constant topic in public goods problems, especially in persistent and complex resource allocation situations. In this paper, a novel allocation policy for public goods games with a complex network, called the proportional-egalitarian allocation method (PEA), is proposed. This allocation rule differs from the well-studied redistribution policies by following a two-step process without paying back into the common pool. A parameter is set up for dividing the total income into two parts, and then they are distributed by following the egalitarianism and proportional rule, respectively. The first part of total income is distributed equally, while the second part is allocated proportionally according to players’ initial payoffs. In addition, a new strategy-updating mechanism is proposed by comparing the average group payoffs instead of the total payoffs. Compared with regular lattice networks, this mechanism admits the difference of cooperative abilities among players induced by the asymmetric network. Furthermore, numerical calculations show that a relatively small income for the first distribution step will promote the cooperative level, while relatively less income for the second step may harm cooperation evolution. This work thus enriches the knowledge of allocation policies for public goods games and also provides a fresh perspective for the strategy-updating mechanism.
Quantum-Like Sampling
Authors: Wichert Andreas
Published: August 2021

Probability theory is built around Kolmogorov’s axioms. To each event, a numerical degree of belief between 0 and 1 is assigned, which provides a way of summarizing the uncertainty. Kolmogorov’s probabilities of events are added, the sum of all possible events is one. The numerical degrees of belief can be estimated from a sample by its true fraction. The frequency of an event in a sample is counted and normalized resulting in a linear relation. We introduce quantum-like sampling. The resulting Kolmogorov’s probabilities are in a sigmoid relation. The sigmoid relation offers a better importability since it induces the bell-shaped distribution, it leads also to less uncertainty when computing the Shannon’s entropy. Additionally, we conducted 100 empirical experiments by quantum-like sampling 100 times a random training sets and validation sets out of the Titanic data set using the Naïve Bayes classifier. In the mean the accuracy increased from 78.84% to 79.46%.
Hierarchical Transfer Learning for Cycle Time Forecasting for Semiconductor Wafer Lot under Different Work in Process Levels
Authors: Wang Junliang , Gao Pengjie , Li Zhe , Bai Wei
Published: August 2021

The accurate cycle time (CT) prediction of the wafer fabrication remains a tough task, as the system level of work in process (WIP) is fluctuant. Aiming to construct one unified CT forecasting model under dynamic WIP levels, this paper proposes a transfer learning method for finetuning the predicted neural network hierarchically. First, a two-dimensional (2D) convolutional neural network was constructed to predict the CT under a primary WIP level with the input of spatial-temporal characteristics by reorganizing the input parameters. Then, to predict the CT under another WIP level, a hierarchical optimization transfer learning strategy was designed to finetune the prediction model so as to improve the accuracy of the CT forecasting. The experimental results demonstrated that the hierarchically transfer learning approach outperforms the compared methods in the CT forecasting with the fluctuation of WIP levels.
Nanostructured Coatings (Ti,Zr)N as a Barrier to Hydrogen Diffusion into Ti0.16Pd (wt.%) Alloy
Authors: Lotkov Aleksandr , Latushkina Svetlana , Kopylov Vladimir , Grishkov Victor , Baturin Anatoly , Girsova Natalia , Zhapova Dorzhima , Timkin Victor
Published: August 2021

The results of a study of structure, phase, and chemical compositions of nanostructured (Ti,Zr)N coatings formed by vacuum arc deposition on Ti0.16Pd (wt.%) alloy substrates are reported. The coating composition was varied depending on the quasi-binary system δ—TiN—δ—ZrN. The coatings were formed in two modes: without (mode 1) and with (mode 2) rotation of the substrates in a plasma flow. It was shown that irrespective of the deposition regime, the coatings have a single-phase nanograined (grain size ≤ 20 nm) structure of δ-nitrides TiN, (Ti,Zr)N, and ZrN. It is found out that the coatings deposited in accordance with modes 1 and 2 significantly differ in their microstructure. It is demonstrated that in the case of electrolytic hydrogenation in a physiological saline solution (0.9% NaCl), the barrier properties of the coatings deposited via mode 2 are substantially better than those deposited via mode 1 (irrespective of the chemical coating compositions). In the coatings with a regular columnar structure (mode 1), there is a high concentration of hydrogen homogeneously distributed over the coating thickness. In the coatings formed via mode 2 (without columnar microstructure), a high concentration of hydrogen was observed in the subsurface area only. It is found out that there is no hydrogen diffusion into the substrate of these coating both immediately after hydrogenation and after storing for 430 h at room temperature. It was shown that the highest barrier properties were exhibited by the (Ti,Zr)N coatings with the least correlation of spatial distribution of nanograins and Zr/Ti ≤ 1. The hydrogen absorption in the coating based on zirconium nitride increases by a factor of 2.
Copper Recovery and Reduction of Environmental Loading from Mine Tailings by High-Pressure Leaching and SX-EW Process
Authors: Godirilwe Labone L. , Haga Kazutoshi , Altansukh Batnasan , Takasaki Yasushi , Ishiyama Daizo , Trifunovic Vanja , Avramovic Ljiljana , Jonovic Radojka , Stevanovic Zoran , Shibayama Atsushi
Published: August 2021

The flotation tailings obtained from Bor Copper Mine contain pyrite (FeS2) and chalcopyrite (CuFeS2), these sulfide minerals are known to promote acid mine drainage (AMD) which poses a serious threat to the environment and human health. This study focuses on the treatment of mine tailings to convert the AMD supporting minerals to more stable forms, while simultaneously valorizing the mine tailings. A combination of hydrometallurgical processes of high-pressure oxidative leaching (HPOL), solvent extraction (SX), and electrowinning (EW) were utilized to recover copper from mine tailings which contain about 0.3% Cu content. The HPOL process yielded a high copper leaching rate of 94.4% when water was used as a leaching medium. The copper leaching kinetics were promoted by the generation of sulfuric acid due to pyrite oxidation. It was also confirmed that a low iron concentration (1.4 g/L) and a high copper concentration (44.8 g/L) obtained in the stripped solution resulted in an improved copper electrodeposition current efficiency during copper electrowinning. Moreover, pyrite, which is primarily in the mine tailings, was converted into hematite after HPOL. A stability evaluation of the solid residue confirmed almost no elution of metal ions, confirming the reduced environmental loading of mine tailings through re-processing.
Preparation and Research of Monolayer WS2 FETs Encapsulated by h-BN Material
Authors: Han Tao , Liu Hongxia , Chen Shupeng , Wang Shulong , Yang Kun
Published: August 2021

Functional devices that use vertical van der Waals (vdWs) heterostructure material can effectively combine the properties of single component materials, and the strong interlayer coupling effect can change their electronic and optical properties. According to our research, WS2/h-BN vertical vdWs heterostructure material can be synthesized by chemical vapor deposition (CVD) and wet transfer methods. Monolayer WS2 material and WS2/h-BN vertical vdWs heterostructure material can be tested and characterized using XPS, SEM, EDS, AFM and Raman spectroscopy, which can prove the existence of corresponding materials. When the thickness of the material decreases, the Coulomb scattering amongst two-dimensional (2D) layered materials increases. This is because both the shielding effect and the distance between the channel and the interface layer decrease. FET devices are then fabricated on WS2/h-BN vdWs heterostructure material by the electron beam lithography and evaporation processes. The effects of vdWs epitaxy on electrical transmission when WS2/h-BN vdWs heterostructure material is formed are explored. Finally, the related electrical performance of FET devices is tested and analyzed. Our experimental research provides guidance for the use of electronic devices with vdWs heterostructure material.
A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems
Authors: Shinha Kenta , Nihei Wataru , Nakamura Hiroko , Goto Tomomi , Kawanishi Takumi , Ishida Naoki , Yamazaki Nao , Imakura Yuki , Mima Shinji , Inamura Kosuke , Arakawa Hiroshi , Nishikawa Masaki , Kato Yukio , Sakai Yasuyuki , Kimura Hiroshi
Published: August 2021

Microphysiological systems (MPSs), including organ-on-a-chip (OoC), have attracted attention as a novel method for estimating the effects and side effects of drugs in drug discovery. To reproduce the dynamic in vivo environment, previous MPSs were connected to pump systems to perfuse culture medium. Therefore, most MPSs are not user-friendly and have poor throughput. We aimed to develop a kinetic pump integrated microfluidic plate (KIM-Plate) by applying the stirrer-based micropump to an open access culture plate to improve the usability of MPSs. The KIM-Plate integrates six multiorgan MPS (MO-MPS) units and meets the ANSI/SBS microplate standards. We evaluated the perfusion function of the kinetic pump and found that the KIM-Plate had sufficient agitation effect. Coculture experiments with PXB cells and hiPS intestinal cells showed that the TEER of hiPS intestinal cells and gene expression levels related to the metabolism of PXB cells were increased. Hence, the KIM-Plate is an innovative tool for the easy coculture of highly conditioned cells that is expected to facilitate cell-based assays in the fields of drug discovery and biology because of its usability and high throughput nature.
Metagenomic Analysis of Bacterial Communities in Agricultural Soils from Vietnam with Special Attention to Phosphate Solubilizing Bacteria
Authors: Hegyi Anna , Nguyen Tran Bao Khuyen , Posta Katalin
Published: August 2021

Bacterial communities can promote increased phosphorus (P) availability for plants and microbes in soil via various mechanisms of phosphate solubilization. The production of extracellular phosphatases releases available P through the hydrolysis of organic P. Examining the abundance and diversity of the bacterial community, including phosphate solubilizing bacteria in soil, may provide valuable information to overcome P scarcity in soil ecosystems. Here, the diversity and relative abundance of bacterial phyla and genera of six agricultural soil samples from Vietnam were analysed by next generation sequencing of the 16S rRNA gene. Phosphatase activities of each soil were compared with physico-chemical parameters and the abundance of the alkaline phosphatase gene phoD. We showed the dominance of Chloroflexi, Proteobacteria, Actinobacteria, Acidobacteria and Firmicutes. Total nitrogen positively correlated with phyla Proteobacteria, Acidobacteria, Firmicutes and Planctomycetes. The abundance of several genera of Proteobacteria showed positive relationship with the copy number of the phoD gene. The abundance of several taxa positively correlated with silt content, while a negative relationship of Proteobacteria was found with sand content. Our results demonstrated the clear influence of soil physico-chemical properties on the abundance of various bacterial taxa including those potentially involved in phosphate solubilization.
Monobac System–A Single Baculovirus for the Production of rAAV
Authors: Galibert Lionel , Jacob Aurélien , Savy Adrien , Dickx Yohann , Bonnin Delphine , Lecomte Christophe , Rivollet Lise , Sanatine Peggy , Boutin Fontaine Marjorie , Le Bec Christine , Merten Otto-Wilhelm
Published: August 2021

Large-scale manufacturing of rAAV is a bottleneck for the development of genetic disease treatments. The baculovirus/Sf9 cell system underpins the first rAAV treatment approved by EMA and remains one of the most advanced platforms for rAAV manufacturing. Despite early successes, rAAV is still a complex biomaterial to produce. Efficient production of the recombinant viral vector requires that AAV replicase and capsid genes be co-located with the recombinant AAV genome. Here, we present the Monobac system, a singular, modified baculovirus genome that contains all of these functions. To assess the relative yields between the dual baculovirus and Monobac systems, we prepared each system with a transgene encoding γSGC and evaluated vectors’ potency in vivo. Our results show that rAAV production using the Monobac system not only yields higher titers of rAAV vector but also a lower amount of DNA contamination from baculovirus.
Editorial for Special Issue: Microbial and Autoimmune Disease
Authors: D’Amelio Raffaele
Published: August 2021

The relationship between microbial and autoimmune disease is reciprocal and multifaceted, thus it may be interpreted in many ways and developed along different, even opposite, lines (Box 1) [...]