bluuebunny/crossref_metadata_2025 huggingface dataset:
The evolving landscape and research trend of calcitonin gene-related peptide in migraine: A bibliometric analysis and visualization
Authors: Wang Liwei , Wang Qing , Diao Huaqiong , Liu Xueying , Zhao Yonglie
Published: June 2024

Background

Migraine is a global public health concern, affecting both social and individual well-being. Calcitonin gene-related peptide (CGRP), a crucial neuropeptide, holds important research value in understanding migraine pathogenesis. CGRP receptor antagonists and monoclonal antibodies that target CGRP or its receptors have shown efficacy in reducing migraine frequency and severity, presenting a promising therapeutic approach. This study aimed to conduct a comprehensive bibliometric analysis to analyze the current state, research trends, and future directions of CGRP in migraine.

Methods

Bibliometric tools including CiteSpace, VOSviewer, etc., were utilized to extract and summarize publications related to CGRP in migraine from the Web of Science Core Collection Database (WOSCC) between 2004 and 2023, as of December 31, 2023. The analysis focused on trends in annual publications, leading countries/regions and institutions, prominent journals and references, influential authors, and high-frequency keywords in the field.

Results

A total of 1,821 articles and reviews involving 5,180 authors from 1,315 organizations across 64 countries were included in the study. These publications were distributed across 362 journals and accumulated 56,999 citations by December 31, 2023. An increasing trend was observed in annual publications on CGRP in migraine. The United States emerged as the leading nation in both publications and citations, with academic Peter Goadsby contributing the highest number of publications. The University of Copenhagen stood out as the institution with the most publications, and Cephalalgia emerged as the most influential journal. The most cited paper identified was “Calcitonin gene-related peptide receptor antagonist BIBN4096BS for the acute treatment of migraine” by Jes Olesen, published in the New Engl Med. Keyword frequency analysis revealed prevalent terms such as “migraine,” “CGRP,” and “episodic migraine,” along with emerging topics represented by keywords including “trial,” “monoclonal antibodies,” “preventive treatment,” and “safety.”

Conclusion

CGRP is pivotal in migraine pathogenesis, and there is a robust research foundation exploring its role. The US leads in research output on CGRP in migraine. Investigating the mechanism of CGRP and its receptor in migraine remains a key area of interest, particularly focusing on signaling pathways. Future research should target identifying critical therapeutic targets in CGRP antagonist pathways for migraine treatment.
Time from injury to acute surgery for patients with traumatic cervical spinal cord injury in South-East Norway
Authors: Aarhus Mads , Mirzamohammadi Jalal , Rønning Pål Andre , Strøm Mona , Glott Thomas , Rizvi Syed Ali Mujtaba , Biernat Donata , Ølstørn Håvard , Rydning Pål Nicolay Fougner , Stenset Vidar Tveit Vasfaret , Næss Pål Aksel , Gaarder Christine , Brommeland Tor , Linnerud Hege , Helseth Eirik
Published: June 2024

Background

The recommended treatment for cervical spinal cord injury (cSCI) is surgical decompression and stabilization within 24 h after injury. The aims of the study were to estimate our institutional compliance with this recommendation and identify potential factors associated with surgical delay.

Methods

Population-based retrospective database study of patients operated for cSCI in 2015–2022 within the South-East Norway Health Region (3.1 million inhabitants). Data extracted were demographics, injury description, management timeline, place of primary triage [local hospital (LH) or neurotrauma center (NTC)]. Main outcome variables were: (1) time from injury to surgery at NTC, (2) time from injury to admission NTC, and (3) time from admission NTC to surgery.

Results

We found 243 cSCI patients having acute neck surgery. Their median age was 63 years (IQR 47–74 years), 77% were male, 48% were ≥65 years old. Primary triage at an LH occurred in 150/243 (62%). The median time from injury to acute surgery was 27.8 h (IQR 15.4–61.9 h), and 47% had surgery within 24 h. The median time from injury to NTC admission was 5.6 h (IQR 1.9–19.4 h), and 67% of the patients were admitted to the NTC within 12 h. Significant factors associated with increased time from injury to NTC admission were transfer via LH, severe preinjury comorbidities, less severe cSCI, time of injury other than night, absence of multiple injuries. The median time from NTC admission to surgery was 16.7 h (IQR 9.5–31.0 h), and 70% had surgery within 24 h. Significant factors associated with increased time from NTC admission to surgery were increasing age and non-translational injury morphology.

Conclusion

Less than half of the patients with cSCI were operated on within the recommended 24 h time frame after injury. To increase the fraction of early surgery, we suggest the following: (1) patients with clinical suspicion of cSCI should be transported directly to the NTC from the scene of the accident, (2) MRI should be performed only at the NTC, (3) at the NTC, surgery should commence on the same calendar day as arrival or as the first operation the following day.
Dexamethasone alleviates etomidate-induced myoclonus by reversing the inhibition of excitatory amino acid transporters
Authors: Feng Yan , Zhang Min , Jia Shuai-ying , Guo Yan-xia , Jia Xue
Published: June 2024

Background

Etomidate can induce myoclonus with an incidence of 50 ~ 85% during anesthesia induction. Dexamethasone, as a long-acting synthetic glucocorticoid, has neuroprotective effects. However, the effects of dexamethasone on the etomidate-induced myoclonus remain uncertain.

Methods

Adult male Sprague–Dawley rats were randomly assigned to receive etomidate (1.5 mg/kg) plus dexamethasone (4 mg/kg) (etomidate plus dexamethasone group) or etomidate (1.5 mg/kg) plus the same volume of normal saline (NS) (etomidate plus NS group). The mean behavioral scores, local field potentials and muscular tension were recorded to explore the effects of dexamethasone on etomidate-induced myoclonus. Liquid chromatography coupled with tandem mass spectrometric system (LC–MS/MS), quantitative real-time polymerase chain reaction (qRT-PCR), and western blotting were applied to analyze the levels of glutamate and γ-aminobutyric acid (GABA), the mRNA and protein expression of excitatory amino acid transporters (EAATs), and plasma corticosterone levels at different time points after anesthesia.

Results

Compared with the etomidate plus NS treatment, the etomidate plus dexamethasone treatment significantly decreased the mean behavioral score at 1, 3, 4, and 5 min after administration; the peak power spectral density (PSD) (p = 0.0197) in the analysis of ripple waves; and the glutamate level (p = 0.0139) in the neocortex. However, compared with etomidate plus NS, etomidate plus dexamethasone increased the expression of the neocortical proteins of EAAT1 (p = 0.0207) and EAAT2 (p = 0.0022) and aggravated the inhibition of corticosterone at 4 h (p = 0.0019), 5 h (p = 0.0041), and 6 h (p = 0.0009) after administration.

Conclusion

Dexamethasone can attenuate the myoclonus, inhibit the glutamate accumulation, and reverse the suppression of EAATs in the neocortex induced by etomidate following myoclonus, while conversely aggravating etomidate-induced adrenal suppression.
Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis
Authors: Zhang Jiale , Zheng Xianhui , Luo Wenting , Sun Baoqing
Published: June 2024

Recent experimental and epidemiological studies underscore the vital interaction between the intestinal microbiota and the lungs, an interplay known as the “gut-lung axis”. The significance of this axis has been further illuminated following the identification of intestinal microbial metabolites, such as short-chain fatty acids (SCFA), as key mediators in setting the tone of the immune system. Through the gut-lung axis, the gut microbiota and its metabolites, or allergens, are directly or indirectly involved in the immunomodulation of pulmonary diseases, thereby increasing susceptibility to allergic airway diseases such as asthma. Asthma is a complex outcome of the interplay between environmental factors and genetic predispositions. The concept of the gut-lung axis may offer new targets for the prevention and treatment of asthma. This review outlines the relationships between asthma and the respiratory microbiome, gut microbiome, and environmental microbiome. It also discusses the current advancements and applications of microbiomics, offering novel perspectives and strategies for the clinical management of chronic respiratory diseases like asthma.
Understanding perspectives of HIV/AIDS affected households on food and nutrition interventions and social protection programmes in Zimbabwe
Authors: George Kembo , Dembedza Mavis Precious , Lesley Macheka
Published: June 2024

Introduction

The study was aimed at understanding the needs and perspectives of HIV affected households on food and nutrition security intervention programmes.

Methods

The study used qualitative methods that include focus groups discussions and key informant interviews to solicit for lived experiences of People Living With HIV (PLWHIV).

Results

The results revealed that intervention programmes by both government and development partners (donors) can be divided into four (4) categories: food and nutrition security, livelihood, health, and social protection. Interventions that targeted health included the provision of HIV antiretroviral drugs to PLWHIV and counselling to both PLWHIV and affected persons. Intervention programmes targeted at social protection included provision of food aid and cash transfers.

Discussion

The recommendations based on the research findings are that intervention programmes should focus more on resilience building as a way of building capacity of PLWHIV. This way, sustainability of intervention programmes is improved. As such, it is important to ensure, through policy, that all intervention programmes have a component of capacity building to improve resilience of participants and programme sustainability. Furthermore, there is a need to improve targeting for beneficiaries of intervention programmes and clearly define the “vulnerable” group.
Associations of dietary selenium intake with the risk of chronic diseases and mortality in US adults
Authors: Zhang Yuchen , Meng Shixin , Yu Yuexin , Bi Liangwen , Tian Jihong , Zhang Lizhen
Published: June 2024

Objective

Selenium is an essential micronutrient and a type of dietary antioxidant. This study aimed to investigate the associations of dietary selenium intake with the risk of human chronic disease [cardiovascular disease (CVD), diabetes mellitus (DM), and cancer] and mortality among US general adults.

Methods

The dietary and demographic data in this study were collected from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. Death outcomes were determined by associating with the National Death Index (NDI) records as of December 31, 2019. Logistic regression analyses were used to investigate the relationship of selenium intake with the risk of CVD, DM, and cancer. The effect of dietary selenium on all-cause and disease-specific mortality was estimated with restricted cubic spline (RCS) curves based on the univariate and multivariate Cox proportional hazard models.

Results

Among the 25,801 participants, dietary selenium intake was divided into quintiles (Q1–Q5). After covariate adjustment, the results showed that the participants with higher quintiles (Q4 and Q5) of selenium intake tended to have a low risk of CVD (OR = 0.97, 95% CI: 0.96, 0.99; OR = 0.98, 95% CI: 0.97, 1.00, respectively). Moreover, the RCS curves showed a significant nonlinear association between selenium intake and the risk of all-cause (with a HR of 0.82, 95% CI: 0.68, 0.99) and DM-specific mortality (with the lowest HR of 0.30; 95% CI, 0.12–0.75). Furthermore, we conducted a subgroup analysis and found a negative correlation between the highest quartile of selenium intake and all-cause mortality among participants aged 50 and above (HR = 0.75, 95% CI: 0.60–0.93, p = 0.009).

Conclusion

Our results indicated that a moderate dietary selenium supplement decreased the risk of CVD and displayed a nonlinear trend in association with the risk of all-cause and DM-specific mortality among US adults. In addition, we found that participants aged 50 and older may benefit from higher selenium intake. However, these findings still need to be confirmed through further mechanism exploration.
Exopolysaccharide from Lacticaseibacillus paracasei alleviates gastritis in Helicobacter pylori-infected mice by regulating gastric microbiota
Authors: Yu Jianxing , Chen Ziqi , Zhou Qingqing , Li Ping , Wu Shiying , Zhou Tao , Gu Qing
Published: June 2024

Introduction

Many probiotics have the ability to produce extracellular polysaccharides (EPS). EPS derived from these probiotics has been confirmed to regulate the host intestinal microecological balance and alleviate the symptoms of diseases caused by gastrointestinal microecological imbalance.

Results

Lactic acid bacteria (LAB) strain with good exopolysaccharide (EPS) producing ability, namely, Lacticaseibacillus paracasei ZFM54 (L. paracasei ZFM54) was screened. The fermentation conditions of L. paracasei ZFM54 for EPS production were optimized. The EPS54 was characterized by chemical component and monosaccharide composition determination, UV, FT-IR and NMR spectra analysis. Cango red, SEM, AFM and XRD analysis were conducted to characterize the structure of EPS54. The EPS54 effectively reduced the colonization of Helicobacter pylori to AGS cells and recovered the cell morphology. EPS54 could also effectively alleviate the gastritis in the H. pylori-infected mice by down-regulating the mRNA expression levels of pro-inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α and up-regulating the mRNA expression of inflammatory cytokine IL-10 in gastric cells. EPS54 was also found to be able to positively regulate the structure of gastric microbiota.

Conclusion

The EPS 54 from L. paracasei ZFM54 can alleviate gastritis in H. pylori-infected mice by modulating the gastric microbiota.
Fibrinogen-to-albumin ratio (FAR) is the best biomarker for the overall survival of patients with non-small-cell lung cancer
Authors: Ma Shixin , Wang Lunqing
Published: June 2024

Objective

The inflammatory response and the nutritional status are associated with overall survival (OS) in patients with non-small cell lung cancer (NSCLC), but it is unclear which biomarkers are better suited to predict prognosis. This study sought to determine which of the commonly existing inflammatory and nutritional indicators best predicted the OS.

Methods

This study included 15 compound indicators based on inflammation or nutrition, with cutoff points obtained through the receiver operating characteristic (ROC) curve. Univariate and multivariate Cox proportional risk models were used to evaluate the relationship between these predictors and OS. Kaplan–Meier curves were used for survival analysis, and log-rank tests were used to compare differences between groups. The C-index was calculated to evaluate the predictive ability of the different indicators.

Results

The study included 899 patients with NSCLC. In the univariate analysis, all 15 measures were significantly associated with the OS of patients (all p < 0.05). The results of the C-index analysis showed that the fibrinogen-to-albumin ratio (FAR), the systemic immune-inflammation index (SII), and the albumin-to-alkaline phosphatase ratio (AAPR) were the three indices with the best predictive performance. Among them, FAR (C-index = 0.639) had the best predictive power for OS in patients with NSCLC. In the different subgroups, FAR had the highest C-index in male, non-smoking, adenocarcinoma, and stage II patients. The C-index of the platelet-to-lymphocyte ratio (PLR) in female patients was the highest. SII was the highest in smokers, in those aged <65 and ≥65 years, and in stage III patients. The C-index of AAPR was the highest in non-adenocarcinomas. The C-index of the pan-immune-inflammation value (PIV) was the highest in stage I patients. In the multivariate Cox regression analysis, among FAR, SII, and AAPR, only FAR was an independent predictor of OS in patients with NSCLC. A high FAR was associated with a higher risk of death in patients with NSCLC (HR = 1.601, 95% CI = 1.028–2.495). In order to further evaluate the potential prognostic value of FAR, SII, and AAPR in patients with different stages, Cox regression analysis was performed for those with stage I–II and stage III NSCLC. The results showed that FAR was an independent prognostic factor for OS in patients with stage I–II NSCLC.

Conclusion

For all patients with NSCLC, the prognostic power of FAR was superior to that of other inflammatory and nutritional indicators.
EGFR-TKIs - induced cardiotoxicity in NSCLC: incidence, evaluation, and monitoring
Authors: Wang Yunlong , Qiu Qinggui , Deng Xuan , Wan Mengchao
Published: June 2024

The advent of targeted drug therapy has greatly changed the treatment landscape of advanced non-small cell lung cancer(NSCLC), but the cardioxic side effects of targeted drug anti-cancer therapy seriously affect the prognosis of NSCLC, and it has become the second leading cause of death in cancer patients. Therefore, early identification of the cardiotoxic side effects of targeted drugs is crucial for the prevention and treatment of cardiovascular diseases. The cardiotoxic side effects that may be caused by novel targeted drugs epidermal growth factor receptor inhibitors, including thromboembolic events, heart failure, cardiomyopathy, arrhythmia and hypertension, are discussed, and the mechanisms of their respective adverse cardiovascular reactions are summarized, to provide useful recommendations for cardiac management of patients with advanced lung cancer to maximize treatment outcomes for lung cancer survivors. Clinicians need to balance the risk-benefit ratio between targeted therapy for malignant tumors and drug-induced cardiotoxicity, and evaluate and monitor TKIs-induced cardiotoxicity through electrocardiogram, cardiac imaging, biomarkers, etc., so as to remove the susceptibility risk factors as soon as possible and provide a reference for the clinical use of such drugs in the treatment of malignant tumors.
Targeting metabolic pathways alleviates bortezomib-induced neuropathic pain without compromising anticancer efficacy in a sex-specific manner
Authors: Kuppusamy Panjamurthy , Haque Md Mamunul , Traub Richard J. , Melemedjian Ohannes K.
Published: June 2024

Introduction

Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of cancer treatment that significantly impacts patients' quality of life. This study investigated the effects of targeting metabolic pathways on bortezomib-induced neuropathic pain and tumor growth using a Lewis lung carcinoma (LLC) mouse model, while exploring potential sex differences.

Methods

Male and female C57BL/6J mice were implanted with LLC cells and treated with bortezomib alone or in combination with metformin, dichloroacetate (DCA), or oxamate. Tactile allodynia was assessed using von Frey filaments. Tumor volume and weight were measured to evaluate tumor growth.

Results

Metformin, DCA, and oxamate effectively attenuated bortezomib-induced neuropathic pain without compromising the anticancer efficacy of bortezomib in both male and female mice. The LLC model exhibited a paraneoplastic neuropathy-like phenotype. Significant sex differences were observed, with male mice exhibiting larger tumors compared to females. Oxamate was more effective in alleviating allodynia in males, while metformin and DCA showed greater efficacy in reducing tumor growth in females.

Discussion

Targeting metabolic pathways can alleviate CIPN without interfering with bortezomib's anticancer effects. The LLC model may serve as a tool for studying paraneoplastic neuropathy. Sex differences in tumor growth and response to metabolic interventions highlight the importance of considering sex as a biological variable in preclinical and clinical studies investigating cancer biology, CIPN, and potential therapeutic interventions.
Improvement of family-centered care in the pediatric rehabilitation ward: a participatory action research
Authors: Nematifard Taban , Arsalani Narges , Nourozi Tabrizi Kian , Fallahi-Khoshknab Masoud , Borimnejad Leili
Published: June 2024

Background and aim

The improved life expectancy of children with disability in recent years has led to their increased request for using lifelong rehabilitation services. Family-centered care (FCC) is a model with potential positive effects on the rehabilitation of children with disability. The present study aimed at improving FCC in the pediatric rehabilitation ward.

Methods

This participatory action research was conducted in 2021–2023 in the pediatric rehabilitation ward of a hospital in Tehran, Iran. Participants were 16 rehabilitation staff and 48 mothers recruited via convenient and purposive sampling methods. Data were collected using semi-structured interviews, focus group discussions, and the 20-item and the 27-item Measures of the Processes Of Care (MPOC). Data were analyzed using qualitative content analysis as well as the Kolmogorov-Smirnov and the Wilcoxon's tests.

Findings

The major barrier to the implementation of FCC was staff and family limited knowledge about the importance and the benefits of FCC and the best facilitator to change was improvement of their knowledge. Therefore, an action plan based on staff and family education was designed and implemented. Participants' positive experiences of the plan were improvement of satisfaction, knowledge, collaboration, and coordination in care and their negative experiences were educational problems and dissatisfaction with the ward atmosphere. The strengths of the plan were adequate number of staff, long enough hospital stay of children, chronic course of disability, and mothers’ previous experiences. Its weaknesses were the long course of a single action plan cycle, exclusive focus on education, and the high risk of plan termination after the study. The practical problems of the study were also small physical space of the ward, transfer of some trained staff to other wards, and child discharge from the hospital.

Conclusion

Staff and family limited knowledge about the importance and the benefits of FCC is a major barrier to effective FCC. Continuous education as well as family and staff collaboration may improve FCC in pediatric rehabilitation ward.
Case Report: Chronic pancreatitis in children as the cumulative effect of bilio-pancreatic abnormalities and genetic mutations
Authors: Destro Francesca , Durante Eleonora , Salerno Raffaele , Campari Alessandro , Meroni Milena , Diotto Veronica , Brunero Marco , Pelizzo Gloria
Published: June 2024

Pancreatitis, in general, is a high-morbidity condition. Genetic conditions and anatomic variants are sometimes seen, especially in children, where biliary etiologies and alcohol are less common than in adults. The decision to intervene, the combined operative-endoscopic strategy, and the timing pose unique challenges. We report the case of a 10-year-old boy with PRSS1 mutation and pancreatic duct duplication, discussing the management and reviewing the recent reports in the Literature.
The effects of aerobic gymnastics training on performance-related variables in an elite athlete: a 2-year follow-up study
Authors: Kyselovičová Oľga , Zemková Erika
Published: June 2024

This study investigates individual performance adaptations on 2 years of training between European Aerobics Championships. An elite, 22-year-old aerobic gymnast performed postural coordination test, Y-Balance test, squat and countermovement jumps, 60 s test of repeated jumps, an isokinetic leg muscle strength test, and the Wingate test. Postural stability and flexibility improved in terms of increased distance achieved in the Y-Balance test in the anterior (by 6.3%), posteromedial (by 2%), and posterolateral (by 4.8%) directions. Lower limb muscular endurance also increased, which can be corroborated by a reduced fatigue index in the 60 s test of repeated jumps (from 42% to 27% after the 1st and to 22% after the 2nd year of training). In addition, mean power increased during dominant (by 23.2% at 60°/s and by 18.5% at 180°/s) and non-dominant leg extension (by 4.9% at 180°/s and by 15.5% at 300°/s), plus dominant leg flexion (by 2.0% at 60°/s and by 6.9% at 300°/s). Similarly, peak torque/body weight ratio increased during dominant (by 24.9% at 60°/s, by 11.5% at 180°/s, and by 2.1% at 300°/s) and non-dominant leg extension (by 0.5% at 60°/s and by 6.4% at 300°/s), plus dominant leg flexion (by 1.7% at 60°/s and by 5.4% at 300°/s). However, 2 years of training failed to show any significant improvements in the explosive power of lower limbs and anaerobic performance. These findings indicate that general aerobic gymnastics training without any specific inputs leads to performance adaptation, namely, in abilities closely related to competition routine (dynamic balance and strength endurance of lower limbs).
Targeting histone deacetylase in cardiac diseases
Authors: Lu Jiao , Qian Sichong , Sun Zheng
Published: June 2024

Histone deacetylases (HDAC) catalyze the removal of acetylation modifications on histones and non-histone proteins, which regulates gene expression and other cellular processes. HDAC inhibitors (HDACi), approved anti-cancer agents, emerge as a potential new therapy for heart diseases. Cardioprotective effects of HDACi are observed in many preclinical animal models of heart diseases. Genetic mouse models have been developed to understand the role of each HDAC in cardiac functions. Some of the findings are controversial. Here, we provide an overview of how HDACi and HDAC impact cardiac functions under physiological or pathological conditions. We focus on in vivo studies of zinc-dependent classical HDACs, emphasizing disease conditions involving cardiac hypertrophy, myocardial infarction (MI), ischemic reperfusion (I/R) injury, and heart failure. In particular, we review how non-biased omics studies can help our understanding of the mechanisms underlying the cardiac effects of HDACi and HDAC.
Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review
Authors: Almaghrbi Heba , Bawadi Hiba
Published: June 2024

Background and aims

Anorexia nervosa (AN) is a complex neuropsychiatric disorder. This systematic review synthesizes evidence from diverse studies to assess and investigate the association between gene polymorphisms and psychological and neurobiological factors in patients with AN.

Methods

A systematic search across PubMed, PsycINFO, Scopus, and Web of Science databases, along with manual searching, was conducted. The review protocol was approved by PROSPERO (CRD42023452548). Out of 1,250 articles, 11 met the inclusion criteria. The quality of eligible articles was assessed using the Newcastle-Ottawa Scale (NOS) tool. The systematic review followed the PRISMA guidelines.

Results

The serotoninergic system, particularly the 5-HTTLPR polymorphism, is consistently linked to altered connectivity in the ventral attention network, impaired inhibitory control, and increased susceptibility to AN. The 5-HTTLPR polymorphism affects reward processing, motivation, reasoning, working memory, inhibition, and outcome prediction in patients with AN. The dopaminergic system, involving genes like COMT, DRD2, DRD3, and DAT1, regulates reward, motivation, and decision-making. Genetic variations in these dopaminergic genes are associated with psychological manifestations and clinical severity in patients with AN. Across populations, the Val66Met polymorphism in the BDNF gene influences personality traits, eating behaviors, and emotional responses. Genes like OXTR, TFAP2B, and KCTD15 are linked to social cognition, emotional processing, body image concerns, and personality dimensions in patients with AN.

Conclusion

There was an association linking multiple genes to the susceptibly and/or severity of AN. This genetic factor contributes to the complexity of AN and leads to higher diversity of its clinical presentation. Therefore, conducting more extensive research to elucidate the underlying mechanisms of anorexia nervosa pathology is imperative for advancing our understanding and potentially developing targeted therapeutic interventions for the disorder.

Systematic review registration: [https://clinicaltrials.gov/], identifier [CRD42023452548].
The body interior in anorexia nervosa: from interoception to conceptual representation of body interior
Authors: Paquet Aude , Girard Murielle , Passerieux Céline , Boule Marie-Christine , Lacroix Aurélie , Sazerat Pierre , Olliac Bertrand , Nubukpo Philippe
Published: June 2024

Background

Body image disorders are well documented in anorexia nervosa (AN); however, knowledge of interoceptive awareness (IA) in this population remains poor. This descriptive study investigated whether and how the representation of the interior of the body may have an impact on IA.

Methods

The representations and knowledge of the body interior were evaluated with a drawing task in 34 women with AN and 34 healthy controls (HCs). A lexicometric analysis was performed on the vocabulary used to describe the drawn body parts in a structured interview. It was assumed that the conceptual representation of the body interior could be affected by or influence IA. Thus, the relationship between IA, measured with the heartbeat task and the ischemia-induction test, and the drawings was explored. Other scales, such as those of body shape, awareness or satisfaction, were used to assess affective representations of the body.

Results

The drawing, lexicometric and IA results were similar in the two groups. No correlations were found among IA, body representation scores and representation level of body interior. Only the representation of bones by the AN group was significantly different.

Discussion

Increased visual attention to the skeleton or greater awareness of bone health could explain the stronger representation of bones in the AN group. The psychophysical therapy received by some AN participants (73%) did not seem to have influenced IA. Our results do not support a relationship between IA and the representation of the body interior.

Clinical trial registration:https://clinicaltrials.gov/, identifier NCT03988218.
Health literacy and associated factors in China: findings from the Wa ethnic group
Authors: Yang Wanqiu , Liu Yi , Zhang Guangjie , Yao Yu , Wang Yanqing , Leng Dan , Li Chaoxiao , Liu Kunjie , Liu Jiazhou , Pu Yongjie , Li Mufei , Yang Borui , Zhang Shuting , Mu Di , Zhang Xiangyang
Published: June 2024

Background

The health literacy of ethnic groups in remote areas of China is far from satisfactory. However, the health literacy of ethnic groups in China remains unclear. This study aimed to explore the health literacy of the “advancing directly” ethnic group and its influencing factors.

Methods

A cross-sectional study was conducted using a staged sampling method among the Wa ethnic group, who have rapidly transitioned directly from the traditional lifestyle of slash-and-burn cultivation to modern societies. We used the Health Literacy Questionnaire (HLQ) to assess health literacy. We defined low health literacy as less than 60% of the total score and adequate health literacy as more than 80% of the total score.

Results

A total of 668 individuals met the inclusion criteria and the mean age was 42.19 (SD 10.56) years. The mean HLQ total score was 29.9 (SD 10.56). The prevalence of adequate health literacy was 0.89%. There were significant differences between the low and the non-low health literacy groups in terms of gender, age, education, marital status, occupation, residing place, current smoking status, and waist circumference (all p < 0.05). Multiple linear regression analysis showed that women (t = 9·418, p < 0.001), older age (B = −0.0091, t = −2.644, p = 0.008), low educational level (B = 0.766, t = 6.018, p < 0.001), current smoking (B = −2.66, t = −3.038, p = 0.008), and residence far from township (B = −5.761, t = −4.1, p < 0.001) were associated with low HLQ total score.

Conclusion

Our findings suggest that the health literacy of the Wa ethnic group is far from favorable. It indicates the need for increased efforts in improving the health literacy of “advancing directly” ethnic groups.
Values-based modes of production and consumption: analyzing how food alternatives transform the current food regime
Authors: Plank Christina , Stotten Rike , Hafner Robert
Published: June 2024

The current food regime has experienced a multidimensional crisis, driving further unjust and unsustainable development. Various food alternatives address these challenges by promoting different modes of alternative production and consumption. However, they are not extensively theoretically addressed within the food regime literature. Thus, we suggest analyzing food regimes with further social science theories to explore food alternatives and their possible contributions to transforming the present food regime. Drawing on a combination of critical state theory, the social capital concept, and territorial approaches, we introduce an interdisciplinary conceptual framework called values-based modes of production and consumption. We assume that food alternatives are based on values other than economic ones, such as democracy, solidarity, or trust. The framework allows examining perspectives of transformation that focus on conflict or cooperation and how they can be interlinked. We aim to determine entry points for analyzing food alternatives within the current food regime because these enable an exchange between debates that are usually taking place alongside each other. By linking them, we aim to inspire further insightful interdisciplinary research.
Intraoperative application of low-dose dexmedetomidine or lidocaine for postoperative analgesia in pediatric patients following craniotomy: a randomized double-blind placebo-controlled trial
Authors: Bao Di , Wang Yaxin , Xiong Wei , Zhang Di , Qiao Lanxin , Zheng Na , Li Lu , Jin Xu
Published: June 2024

Background

Postoperative pain is a common occurrence in pediatric patients following craniotomy, often leading to negative outcomes. Intravenous dexmedetomidine and lidocaine are commonly used adjuvant medicines in general anesthesia to reduce perioperative opioid consumption and relieve postoperative pain in adults. While they show promise for use in pediatrics, the evidence of their application in pediatric craniotomy patients is limited. Therefore, we aimed to compare the effects of dexmedetomidine and lidocaine on postoperative pain in pediatric patients following craniotomy.

Methods

We conducted a randomized, double-blind, single-center trial on children scheduled for craniotomy. The 255 recruited participants aged 1–12 years were randomly assigned to intraoperatively receive a loading intravenous dose of either dexmedetomidine 1 μg·kg−1 or lidocaine 2 mg·kg−1 or normal saline for 15 min followed by dexmedetomidine 0.5 μg·kg−1·h−1 or lidocaine 1 mg·kg−1·h−1 or normal saline until the sutures of endocranium were completed. The primary outcome was the cumulative sufentanil consumption within 24 h post-surgery.

Results

A total of 241 patients were included in the statistical analysis. The primary outcome did not show any significant differences among the three groups (median (IQR) lidocaine group: 3.36 (1.32–5.64) μg vs. dexmedetomidine group: 3.12 (1.36–6.39) μg vs. control group 3.46 (1.77–7.62) μg, p = 0.485). Among the secondary outcomes, there was a statistically significant but small reduction in sufentanil consumption within 2 h, postoperative FLACC/WBFS/NRS pain scores within 4 h after surgery and postoperative Ramsay sedation scores in dexmedetomidine group (p < 0.05). Regarding postoperative complications, the incidence of electrolyte disturbance within 24 and 48 h after surgery was significantly higher in control group compared to the other two groups. There were no significant differences in intraoperative opioid consumption, postoperative frequency of remedy medication, or length of hospitalization among the three groups. No adverse events related to lidocaine or dexmedetomidine were observed.

Conclusions

There were no significant differences in the primary outcome among the three groups. Although dexmedetomidine showed some benefits in reducing postoperative opioid consumption within the first 2 h and pain intensity within the first 4 h post-surgery, these findings should be interpreted with caution. Further research is required to comprehensively assess the outcomes and determine the optimal administration strategy.

Clinical Trial Registration

[http://www.chictr.org.cn/index.aspx], identifier [ChiCTR1800019411].
Verification of Control System Runtime Using an Executable Semantic Model
Authors: Sadolewski Jan , Trybus Bartosz
Published: June 2024

The paper outlines a methodology for validating the accuracy of a control system’s runtime implementation. The runtime takes the form of a virtual machine executing portable code compliant with IEC 61131-3 standards. A formal model, comprising denotational semantics equations, has been devised to specify machine instruction decoding and operations, including arithmetic functions across various data types, arrays, and subprogram calls. The model also encompasses exception-handling mechanisms for runtime errors, such as division by zero and invalid array index access. This denotational model is translated into executable form using the functional F ♯ language. Verification involves comparing the actual implementation of the virtual machine against this executable model. Any disparities between the model and implementation indicate deviations from the specification. Implemented within the CPDev engineering environment, this approach ensures consistent and predictable control program execution across different target platforms.
Research on Multi-Mode Variable Parameter Intelligent Shift Control Method of Loader Based on RBF Network
Authors: Wu Guanghua , Jin Tianyu , Wang Junnian
Published: June 2024

The loader is one of the most widely used pieces of engineering machinery in the world for soil transportation, loading and unloading materials, and low-intensity shovel digging operations in harsh and complex operating conditions; it requires very frequent shifting and has other challenging characteristics. In order to realize automatic frequent shifting, we need to better design the shifting rules in the shifting process, improve the shifting quality and working efficiency, and solve the key engineering problems of energy saving and high efficiency in the shifting process of loaders. In this paper, a 7-ton wheel loader is taken as the research object, the loader shoveling process of the four operating modes is analyzed, and a multi-mode variable parameter shift law is designed. Aiming at the complicated and nonlinear characteristics of the power transmission system of the loader, an intelligent shift control method based on an RBF neural network is proposed. Finally, the simulation test and the clutch shift oil pressure test are carried out. From the test results, the clutch test oil pressure curve obviously shows a four-stage upward trend during shifting, and the buffering effect is obvious. The designed multi-mode variable-parameter intelligent shift law of the loader is reasonable and feasible, and the shift recognition rate reaches 97.92%, which provides theoretical support for the realization of intelligent automatic speed change control of the loader, and it certainly has engineering value.
A Grain Number Counting Method Based on Image Characteristic Parameters of Wheat Spikes
Authors: Li Yinian , Du Shiwei , Zhong Hui , Chen Yulun , Liu Yingying , He Ruiyin , Ding Qishuo
Published: June 2024

In order to measure wheat yield and wheat spike phenotypes, the grain number of wheat spikes is counted manually at present, but acquiring the grain number of wheat spikes is laborious and time-consuming. Counting the grain number of wheat spikes with an image processing method is promising, yet the application of this method is flawed due to its low accuracy. In this work, images of wheat spikes were collected and processed with technical procedures, including image cropping, image graying, histogram equalization, image binarization, eroding operation, removing small objects, filling image holes, revolving vertical spikes, cutting off stems, and removing stems. Wheat stems in binary images were eliminated by the sum pixels method, and the morphological characteristic parameters of the image areas of wheat spikes and lengths of wheat spike axes were calculated. Mathematical models relating the image areas of wheat spikes and lengths of the wheat spike axes to the grain number were established, and the mathematical models were verified. The results showed that the characteristic parameters of the image areas of wheat spikes and the lengths of the wheat spike axes for the spike images were linear relative to the grain number, and the maximum determination coefficients R2 were 0.9336 and 0.9012, respectively. The maximum determination coefficients R2 for the practical and predicted grain numbers were 0.9552 and 0.9369, respectively, and the minimum average absolute error was 2.3, while the average relative error for the mathematical models was 5.65%. The mathematical models relating the image areas of wheat spikes and the lengths of the wheat spike axes to the grain number were practical and accurate, and the mathematical model comparing the image area of wheat spikes and the grain number was superior to that comparing the length of the wheat spike axis and the grain number. The grain number of wheat spikes could be acquired accurately and quickly by the image processing method extracting the characteristic parameters of wheat spikes.
CES-YOLOv8: Strawberry Maturity Detection Based on the Improved YOLOv8
Authors: Chen Yongkuai , Xu Haobin , Chang Pengyan , Huang Yuyan , Zhong Fenglin , Jia Qi , Chen Lingxiao , Zhong Huaiqin , Liu Shuang
Published: June 2024

Automatic harvesting robots are crucial for enhancing agricultural productivity, and precise fruit maturity detection is a fundamental and core technology for efficient and accurate harvesting. Strawberries are distributed irregularly, and their images contain a wealth of characteristic information. This characteristic information includes both simple and intuitive features, as well as deeper abstract meanings. These complex features pose significant challenges to robots in determining fruit ripeness. To increase the precision, accuracy, and efficiency of robotic fruit maturity detection methods, a strawberry maturity detection algorithm based on an improved CES-YOLOv8 network structure from YOLOv8 was developed in this study. Initially, to reflect the characteristics of actual planting environments, the study collected image data under various lighting conditions, degrees of occlusion, and angles during the data collection phase. Subsequently, parts of the C2f module in the YOLOv8 model’s backbone were replaced with the ConvNeXt V2 module to enhance the capture of features in strawberries of varying ripeness, and the ECA attention mechanism was introduced to further improve feature representation capability. Finally, the angle compensation and distance compensation of the SIoU loss function were employed to enhance the IoU, enabling the rapid localization of the model’s prediction boxes. The experimental results show that the improved CES-YOLOv8 model achieves an accuracy, recall rate, mAP50, and F1 score of 88.20%, 89.80%, 92.10%, and 88.99%, respectively, in complex environments, indicating improvements of 4.8%, 2.9%, 2.05%, and 3.88%, respectively, over those of the original YOLOv8 network. This algorithm provides technical support for automated harvesting robots to achieve efficient and precise automated harvesting. Additionally, the algorithm is adaptable and can be extended to other fruit crops.
Assessing the Influence of Guanidinoacetic Acid on Growth Performance, Body Temperature, Blood Metabolites, and Intestinal Morphometry in Broilers: A Comparative Sex-Based Experiment
Authors: Al-Abdullatif Abdulaziz A. , Azzam Mahmoud M. , Samara Emad M. , Al-Badwi Mohammed A. , Dong Xinyang , Abdel-Moneim Abdel-Moneim Eid
Published: June 2024

It is well known that female and male broilers showcase variations in their growth performance, influenced by various physiological factors. This experiment aims to explore potential differences between female and male broilers concerning growth performance, body temperature, blood metabolites, carcass traits, and intestinal architecture in response to guanidinoacetic acid (GAA) supplementation. A total of 240 Ross 308 broiler chickens were arranged in a 3 × 2 factorial design and randomly allocated into 48 boxes, each containing 5 birds. The experiment comprised six treatments, with eight replicates per treatment. The main factors investigated were dietary GAA levels (0%, 0.06%, and 0.12%) and sex (male and female). Male broilers demonstrated superior body weight gain (BWG) and feed intake (FI) compared to females (p< 0.05). GAA supplementation at 0.12% concentration notably improved BWG and reduced FI and feed conversion ratio (FCR) across experimental phases (p < 0.05). However, interactions between sex and GAA were minimal except for reduced FI and FCR (p < 0.05) in both sexes during early growth stages. Regardless of GAA treatment, the male birds exhibited more elevated shank and head temperatures than the females. Carcass traits were largely unaffected by GAA supplementation or sex, except for higher heart yield in the males. Serum metabolite levels were not different between treatment groups at 10 and 24 days of age, except for a higher level of serum creatinine at 10 days in the female birds with 0.06% GA supplementation (p < 0.05). Intestinal morphology was significantly affected by GAA and sex, depending on the segment of intestine, in which GAA supplementation significantly increased villus height, crypt depth, villus width, surface area, and goblet cell count, while the males consistently exhibited higher values of these parameters than the females, and differences were observed between intestinal segments, especially in the ileum and duodenum, at different ages. In conclusion, the interactions between GAA and sex had minimal influences on growth performance indices. However, male broilers demonstrated a more pronounced response to GAA concerning ileal architecture. This study highlights the importance of supplementing broiler chicken diets with GAA for optimizing male broiler performance and intestinal function. The inclusion of GAA into broiler diets needs further study to reveal the underlying mechanisms driving these sex-specific responses and assess the long-term impacts of GAA supplementation on broiler health and productivity.