bluuebunny/crossref_metadata_2025 huggingface dataset:
Deletion of DYRK1A accelerates osteoarthritis progression through suppression of EGFR-ERK signaling
Authors: Liu Zhibo , Hu Shidong , Wu Jiangping , Quan Xiaolin , Shen Chen , Li Zhi , Yuan Xin , Li Xiangwei , Yu Chao , Wang Ting , Yao Xudong , Sun Xianding , Nie Mao
Published: December 2022

Purpose
Dual-specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) signaling is involved in the dynamic balance of catabolism and anabolism in articular chondrocytes. This study aimed to investigate the roles and mechanism of DYRK1A in the pathogenesis of osteoarthritis (OA).
Methods
The expressions of DYRK1A and its downstream signal epidermal growth factor receptor (EGFR) were detected in the cartilage of adult wild-type mice with destabilized medial meniscus (DMM) and articular cartilage of patients with OA. We measured the progression of osteoarthritis in chondrocyte-specific knockout DYRK1A(DYRK1A-cKO) mice after DMM surgery. Knee cartilage was histologically scored and assessed the effects of DYRK1A deletion on chondrocyte catabolism and anabolism. The effect of inhibiting EGFR signaling in chondrocytes from DYRK1A-cKO mice was analyzed.
Results
Trauma-induced OA mice and OA patients showed down-regulation of DYRK1A and EGFR signaling pathways. Conditional DYRK1A deletion aggravates DMM-induced cartilage degeneration, reduces the thickness of the superficial cartilage and increases the number of hypertrophic chondrocytes. The expression of collagen type II, p-ERK and aggrecan was also down-regulated, and the expression of collagen type X was up-regulated in the articular cartilage of these mice.
Conclusion
Our findings suggest that DYRK1A delays the progression of knee osteoarthritis in mice, at least in part, by maintaining EGFR-ERK signaling in articular chondrocytes.
Predictive Value of Forearm Muscle Oxygenation Parameters for Climbing-specific Finger Endurance and Competitive Climbing Performance
Authors: Winkler Marvin , Künzell Stefan , Augste Claudia
Published: December 2022

Purpose
Near-infrared spectroscopy (NIRS) is a valid and reliable method to assess forearm muscle oxygenation in sport climbing, focusing on evaluating single parameters. The study assessed the predictive value of various NIRS parameters in climbing-specific settings, during intermittent finger endurance testing and in a simulated climbing competition.
Methods
52 recreational climbers (28.5 ± 6.3 y) performed an intermittent finger endurance test and 10 competitive climbers (20.2 ± 6.3 y) participated in a simulated lead climbing competition. Continuous-wave NIRS were used to assess oxygenation and blood volume changes.
Results
NIRS parameters predicted 264 % of the variance in the intermittent test, with mean minima and maxima of O2Hb and mean maxima of TSI% of the single repetitions being the predictors. No significant differences existed between the last valid and the first nonvalid on the combined dependent variable. For the simulated competition, a statistically significant difference between the 20s intervals on the combined dependent variables were found with posthoc testing showing significant univariate within-subjects effects for HHb, tHb & TSI, but not for O2Hb.
Conclusion
The results indicate that for the intermittent test, high re- and deoxygenation abilities, and for the climbing competition, the accumulation of HHb concentration levels have the highest predictability.
Zalcman functional of logarithmic coefficients of inverse functions in certain classes of analytic functions
Authors: Lecko Adam , Śmiarowska Barbara
Published: December 2022

We study Hankel matrices whose entries are logarithmic coefficients of inverse functions in selected subclasses of analytic functions. Particularly, we give sharp bounds for the second Hankel determinant which reduces to Zalcman functional of logarithmic coefficients of inverse convex and starlike functions, as well as of functions of bounded turning.
Mathematics Subject Classification (2010) 30C45 · 30C50 · 30C55
Evaluation of the performance of "Advantage P.f. Malaria Card® " and " Advantage Malaria Pan+Pf Card® " two rapid diagnostic tests for biological confirmation of malaria cases in field situation in Togo
Authors: TEOU Diwaba Carmel , DORKENOO Ameyo Monique , ATABA Essoham , YAKPA Kossi , ABDOU-KERIM Agueregna , MAMAN Issaka , AGBONON Amegnona
Published: December 2022

Background
In Togo, malaria remains a major public health problem and the management of suspected cases requires confirmation with appropriate biological methods. Indeed, malaria diagnosis has been improved through the introduction of rapid diagnostic tests (RDTs), recommended by the World Health Organization (WHO) for areas where microscopy is not available. To be used, these RDTs must meet performance criteria defined by the WHO. This study was conducted to evaluate the diagnostic performance of two RDTs: Advantage P.f. Malaria Card® detecting HRP2 antigen and Advantage Malaria Pan + Pf Card® detecting both HRP2 and pLDH antigens.
Methods
This was a cross sectional analytical study conducted from December 2019 to February 2020 on malaria suspected cases seen in three sentinel sites in Togo and from whom capillary blood was collected to perform the two RDTs according to the procedures described by the manufacturer. The performance was estimated comparing to thick/thin blood smear and molecular biology (PCR), considered as gold standard.
Results
The sensitivity of both Advantage P.f. Malaria Card® and Advantage Malaria Pan + Pf Card® compared to thick /thin blood smear was 91.8% and 91.3% respectively and for both the specificity was 94.7%. Compared to PCR, the sensitivity decreased to 89.4% and 88.9% respectively and their specificity to 72.2%.
Conclusion
The performance of the Advantage P.f. Malaria Card® and Advantage Malaria PAN + Pf Card® compared to microscopy, considered as the gold standard, according to WHO criteria were acceptable. They can therefore be used for the biological diagnosis of malaria.
Ammonium-based ionic liquids: cross-validation of energetics using solution calorimetry, quartz crystal microbalance, quantum chemistry, and structure– property relationships
Authors: Verevkin Sergey P. , Zaitsau Dzmitry H. , Yermalayeu Andrei V. , Vostrikov Sergey V.
Published: December 2022

The solution enthalpies of tetra-methyl- and tetra-butyl-ammonium tetra-fluoroborates were measured using solution calorimetry. The sublimation enthalpies and vaporisation enthalpies of ammonium-based ionic liquids with the anions [BF4] and [NO3], were derived from temperature dependencies of the vapor pressures, measured with a quartz crystal microbalance and adjusted to the reference temperature 298.15 K. The solution calorimetry results were used to derive the solid phase enthalpies of formation of the compounds studied. The latter results were combined with the sublimation enthalpies to obtain the experimental gas phase formation enthalpies of the ionic liquid containing [BF4] and [NO3] anions. The theoretical gas phase formation enthalpies were calculated using the quantum chemical method G3MP2 and agree well with the experimental results. Different types of structure–property relationships were used to establish the consistency of the alkyl-ammonium-based ionic liquids studied in this work.
Specific morphological features of congenital heart disease relevant to outcomes in patients with right isomerism
Authors: Tomita Yoshitaka , Muneuchi Jun , Ezaki Hiroski , Kobayashi Masaru , Yamada Hiromu , Sugitani Yuichiro , Watanabe Mamie
Published: December 2022

Purpose
Children with right isomerism accompany complex congenital heart disease, which is related to high mortality and morbidity, especially total anomalous pulmonary venous connection and common atrioventricular valve regurgitation. This study aimed to explore specific cardiac morphological features relevant to poor outcomes based on computed tomography (CT) in children with right isomerism.
Methods
We retrospectively reviewed contrasted CT images in patients with right isomerism, and assessed cardiac morphological features including the atrial and ventricular connections, the special relationship between the aorta and the pulmonary trunk, the appendages, pulmonary venous channels, and caval veins. In particular, we focused symmetry of the heart base which was defined as the atrial appendages were symmetrically positioned on either side of the antero-posteriorly great arteries. We analyzed the morphological features relevant to total anomalous pulmonary venous connection which is the risks for poor outcomes.
Results
Thirty patients with right isomerism were studied. Atrial situs was classified into situs in 11, and inversus in 19 patients. Atrioventricular and ventriculoarterial discordances were observed in 17 and 26 patients, respectively. Ventricular morphological features included single ventricle in 14, unbalanced atrioventricular septal defect in 6, pulmonary atresia in 11, pulmonary stenosis in 17, and bilateral superior caval veins in 14. There were 18 patients (60%) with extracardiac total anomalous pulmonary venous drainage (preoperative obstruction: N = 8), which was significantly correlated to symmetry of the heart base (P < 0.001).
Conclusions
The heart base symmetry correlated to total anomalous pulmonary venous drainage.
Association between dietary hardness and cognitive dysfunction among Japanese men in their 60s: a cross-sectional study
Authors: Fujiwara Aya , Fukunaga Ami , Murakami Kentaro , Inoue Yosuke , Nakagawa Tohru , Yamamoto Shuichiro , Konishi Maki , Mizoue Tetsuya
Published: December 2022

Background: Although the association between dietary components (e.g. nutrients, foods, and dietary patterns) and cognitive dysfunction has been extensively investigated, a limited number of studies have been conducted on dietary hardness, despite its possible role in increasing masticatory activity and improving cognitive function. We aimed to examine the cross-sectional association between the hardness of habitual diet and cognitive dysfunction among Japanese men in their 60s.
Methods: Data were obtained from 1,494 men aged 60– 69 years who participated in the baseline survey of Hitachi Health Study II (2017–2020). Dietary hardness was assessed using the information on the habitual intake of solid foods, which was assessed using a brief-type, self-administered diet history questionnaire, and the magnitude of masticatory muscle activity required for consuming each food item, which was available in a published database. The sum of masticatory muscle activity involved in consuming food items was used as an estimate of dietary hardness. Cognitive dysfunction was defined as a score ≤ 13 points on the test battery for screening for Alzheimer’s disease (MSP-1100). Logistic regression models were used to examine the association between dietary hardness and cognitive dysfunction.
Results: The mean (standard deviation) age of participants was 63.5 (3.5) years. The prevalence of cognitive dysfunction was 7.5%. The odds ratios (95% confidence intervals) for cognitive dysfunction in the second and third tertiles were: 0.76 (0.46, 1.25) and 0.86 (0.53, 1.39), respectively, after adjustment for socio-demographic factors (P for trend = 0.70). After further adjustment for protective nutrient intake against cognitive dysfunction, the corresponding figures were 0.72 (0.43, 1.21) and 0.79 (0.43, 1.45), respectively (P for trend = 0.60).
Conclusions: Hardness of the habitual diet was not associated with the prevalence of cognitive dysfunction among Japanese men in their 60s. Future prospective studies are necessary to investigate the association between dietary hardness estimated a validated questionnaire and cognitive dysfunctions.
The incidence of postoperative vasopressor usage, a prospective international observational study: ‘SQUEEZE’
Authors: Creagh-Brown Ben , Wunsch Hannah , Martin Peter , Harlem Pierre , Forni Lui , Moonesinghe S. Ramani , Jammer Ib
Published: December 2022

Background: Postoperative hypotension is common after major non-cardiac surgery, due predominantly to vasodilatation. Administration of infused vasopressors postoperatively may often be considered a surrogate indicator of vasodilatation. The incidence of postoperative vasopressors and outcomes associated with their use has never been described.
We hypothesise that there is variation across centres in using vasopressors after surgery. There may also be a variation in the incidence of organ dysfunction, organ support use, and clinical outcomes in patients treated with postoperative vasopressor therapy.
Method: The primary objective of this study is to determine what proportion of patients receive postoperative vasopressor infusions. We will identify factors in variation of care (patient, condition, surgery, and intraoperative management) associated with the receipt of postoperative vasopressor infusions. We will also assess the incidence of associated organ dysfunction and clinical outcomes among those who receive vasopressors. This will be accomplished with a prospective, international, multicentre cohort study that includes all adult (≥18 years) non-cardiac surgical patients in participating centres. Patients undergoing cardiac, obstetric or day-case surgery will be excluded. We will recruit two cohorts of patients: Cohort A will include all eligible patients admitted to participating hospitals for seven consecutive days. Cohort B will include 30 sequential patients per hospital, with the single additional inclusion criterion of postoperative vasopressor usage. We expect to collect data on approximately 40,000 patients for cohort A and 12,800 patients for cohort B.
Discussion: While in cardiac surgery, clinical trials have informed the choice of vasopressors used to treat postoperative vasoplegia, there remains equipoise over the best approach in non-cardiac surgery. Our study will represent the first large-scale assessment of the use of vasopressors after non-cardiac surgery. These data will inform future studies, including trials of different vasopressors and potential management options to improve outcomes and reduce resource use after surgery.
Trial registration: ClinicalTrials.gov Identifier: NCT03805230, 15th January 2019
Prevalence and Associated Factors of Asymptomatic Malaria among Pregnant Women at Boset District in East Shoa Zone, Oromia Region, Ethiopia, 2022
Authors: Balcha Fufa , Menna Takele , Lombabo Fantu
Published: December 2022

Background: Malaria is caused by protozoan parasites of the genus Plasmodium infecting red blood cells. Malaria infection during pregnancy is a significant public health problem that puts pregnant women at risk. Due to the asymptomatic nature of malaria patients, diagnosis has been difficult, definitions have been inconsistent, and there has been a general lack of urgency to explore this illness outcome. Because asymptomatic malaria represents a challenge in interrupting transmission in a population and the asymptomatic host serves as a reservoir for the malaria parasite, it is now recognized as a major barrier to malaria elimination. This study aims to assess the prevalence of asymptomatic malaria and associated factors among pregnant women in the Boset District, East Shoa Zone, Oromia, Ethiopia
Methods: A community-based cross-sectional study was conducted to assess the prevalence and associated factors of asymptomatic malaria in pregnant women from February to March 2022. Using multistage sample techniques, 328 asymptomatic pregnant women were enrolled. Data were collected using a structured questionnaire. A rapid test and Giemsa-stained blood smear microscopy were used to diagnose Plasmodium infections. Epi info version 7 was used to code, enter, and clean data before being uploaded to SPSS version 25.0 for analysis. Bivariable and multivariable binary logistic regression were utilized to find the associated factors.
Results: Of the total 328 pregnant women who participated in this study, 9(2.74%) and 10(3.05%) were confirmed to be infected with Plasmodium species by microscopy and rapid diagnostic tests, respectively. Malaria during pregnancy was found to be significantly associated with not using an insecticide-treated bed net [AOR: 9.66; 95 % CI: (2.03-45.98), lack of consultation and health education about malaria prevention during Antenatal care attendance [AOR: 4.19; 95 % CI: (1.07, 16.44), and living close stagnant water [AOR: 7.58; 95% CI: (1.06, 18.66).
Conclusions: The current study showed asymptomatic malaria is prevalent in pregnant women. Insecticide-treated bed nets, Health education during Antenatal care, and living close to stagnant water had a significant association with malaria. This indicates pregnant women have to be screened for asymptomatic malaria and educated on malaria preventive methods during Antenatal care services.
Knowledge Field and Emerging Hotspots in Tongue Cancer Research: A Bibliometric and Visual Analysis
Authors: Mo Xiaoqiang , Ou Mingyu , Li Qing , Mo Huajun , Li Jun , Wang Shan , Yao Jinguang
Published: December 2022

Objective:The aim of this study is to provide a clear and intuitive overview of the current knowledge structure and potential future research trends in the TSCC field through bibliometric and visual analysis of publications.Methods:Bibliographic data for publications in the TSCC field from 2001 to 2021 were extracted from the Web of Science Core Collection. Data were visualized and analyzed using Microsoft Excel, VOSviewer, CiteSpace, R package bibliometrix, SCImago Graphica Beta, and Pajek software.Results:A total of 9734 publications related to TSCC were identified. The United States is the leader in the TSCC field, with the highest productivity, citations, centrality, and sigma values. The most productive institution is Sun Yat-sen University in China. ORAL NCOLOGY and SALO T are the most influential and productive journals and authors respectively. Keyword analysis found that research on TSCC sub-fields Neck dissection, Human papillomavirus, Diagnosis is decreasing, while Apoptosis, Quality of life and other fields are still hot. Depth of invasion, Bio-mark and Resistance are emerging keywords in recent years. The co-citation analysis of the literature found that the research focus in the field of TSCC has gradually changed from E-cadherin, Metastases, Epidemiological, Sentinel lymph node and other fields to Depth of invasion, Transoral robotic surgery, Lymphatic, Young patient, and Tumor budding.Conclusions:At present, this field focuses more on clinical research and less on basic research. Depth of invasion, Bio-mark, Transoral robotic surgery, young patient, and Tumor budding are emerging sub-fields of TSCC and potential future research trends.
Bioinformatics analysis and experimental validation of Cystathionine-gamma-lyase as a potential biomarker for prognosis in hepatocellular carcinoma
Authors: Ma Yanan , Wang Shanshan , Ding Huiguo
Published: December 2022

Purpose Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality worldwide. Although cystathionine-gamma-lyase(CSE) plays an important role in the development of multiple tumors, the clinical implication and potential mechanisms of CSE in HCC development remain elusive.
Methods The CSE expression in HCC was analyzed in GEO and TCGA datasets and verified in 45 HCC patients samples by RT-qPCR and immunohistochemistry assays. Furthermore, the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC patients. Cox proportional hazard model was used to identify prognostic factors for overall survival(OS) and recurrence-free survival(RFS) in GSE14520. CCK-8 and flow cytometry were used to assess the biological functions of CSE in HCC cells, including cell proliferation and apoptosis.
Results Lower transcriptional and proteomic CSE expressions were found in HCC tissues in contrast to adjacent normal tissues. Decreased CSE mRNA expression was significantly associated with advanced clinicopathological features and poor survival in HCC patients from public database and our cohort. Following univariate and multivariate analyses of GSE14520 data showed that CSE expression was an independent prognostic indicator for the OS and RFS of HCC patients. Notably, inhibition of CSE with PPG, facilitated proliferation and suppressed apoptosis in HCC cells via H2S.
Conclusion In summary, the present study identified the relationship between CSE expression and HCC malignancy as well as OS and RFS, suggestting that CSE might be a potential prognostic biomarker and a novel therapeutic target in cancer therapy.
Effect of autologous platelet-rich plasma on patients with acute type A aortic dissection underwent aortic arch replacement: a retrospective cohort study
Authors: Wei Xiaojin , Chen Kai , Wang Ruixuan , Wang Yaping
Published: December 2022

Background
Coagulopathy and massive bleeding are common complications of patients with Stanford type A acute aortic dissection repair, and patients with these complications require many transfusions. Autologous platelet-rich plasma (PRP) is widely used to reduce the need for blood products. In the present study, we aimed to investigate the effects of PRP on blood conservation and the postoperative conditions of patients who underwent aortic arch replacement.
Methods
Patients with aortic dissection undergoing aortic arch replacement were included initially application In all, 837 patients were divided into the PRP and non-PRP groups according to PRP use, whereupon a propensity score match was performed. The data analyzed included patient basic information, intraoperative information, postoperative biochemical examinations, and CTA reports.
Results
In total, 610 patients were finally included (305 patients per group). Groups were well balanced after matching. Compared to the non-PRP group, less cryoprecipitate was transfused in the PRP group (10.0 [7.5, 11.0] vs. 10.0 [10.0, 11.5], P = 0.021), while no differences were found in packed RBC, FFP, and platelets between the two groups. Also, the surgery variables showed no differences. After surgery, patients in the PRP group showed higher postoperative serum albumin (36.43 ± 4.20 vs. 35.39 ± 4.40 g/L, P = 0.004) and total protein levels (59.38 ± 6.25 vs. 58.06 ± 7.19 g/L, P = 0.019) than the non-PRP group, but no significant differences in the levels of ALT, AST, Scr, and BUN. CTA reports showed that the proportion of patients with pleural effusion was lower in the PRP group (76.66% vs. 83.99%, OR = 1.59, 95% CI: 1.04–2.45, P = 0.028), while the proportions of pericardial effusion were not significantly different.
Conclusions
PRP application in aortic arch replacement surgery reduced the transfusion of cryoprecipitate, increased the postoperative serum albumin and total protein levels, and reduced the incidence of pleural effusion. No effect of PRP application was found on other postoperative blood indicators and CTA reports.
High Prevalence of Abnormal Hemoglobin A1c in the Adolescent and Young Adult Fontan Population
Authors: Woo Jennifer P. , Romfh Anitra , Levin Genevieve , Norris Jana , Han Jamie , Grover Monica , Chen Sharon
Published: December 2022

Little is known about diabetes risk in adolescents and young adults with Fontan circulation. We sought to understand the prevalence of abnormal hemoglobin A1c (HgA1c) in the adolescent and young adult population with Fontan palliation. Between 2015 and 2021, 78 Fontan patients >10 years of age were seen in our single ventricle clinic; 66 underwent screening with HgA1c. 50% of the study cohort (n=33) had HgbA1c >5.7%; 2% (n=1) had HgbA1c >6.5%. There was no correlation between BMI and HgbA1c, with no difference in the prevalence of overweight or obesity (BMI >85th percentile) between those with and without abnormal HbgA1c (31% versus 27%, p=0.69). While 20% of the cohort had a family history of diabetes, there was no difference in family history between those with and without abnormal HgbA1c (21% versus 19%, p=0.85). There were no differences in other risk factors and characteristics (race, GFR, liver function, lipid panel, hematocrit, and years from Fontan surgery) between those with and without normal HgbA1c. Our results highlight the importance of recognizing that abnormal HbA1c is highly prevalent in the Fontan population. Whether abnormal HgA1c in this population correlates with atherosclerotic cardiovascular disease in adulthood is not known. Prior studies have suggested an association among metabolic syndrome, activation of the renin-angiotensin system, chronic liver disease, chronic kidney disease, and reduced muscle mass with impaired glucose tolerance in the adult Fontan population. The mechanism for an abnormal HgA1c in the adolescent and young adult Fontan population remains unclear and further studies are needed.
Machine Learning to Improve Resident Scheduling: Harnessing Artificial Intelligence to Enhance Resident Wellness
Authors: Abbas Aazad , Toor Jay , Du Jin Tong , Versteeg Anne , Yee Nicholas J , Finkelstein Joel A. , Abouali Jihad , Nousiainen Markku T. , Kreder Hans J , Hall Jeremy , Whyne Cari , Larouche Jeremie
Published: December 2022

Purpose

Excessive resident duty hours (RDH) is a recognized issue with implications for physician well-being and patient safety. A significant component of the RDH concern is on-call duty. While other industries have adopted machine learning models (MLMs) to optimize scheduling and employee well-being, medicine has lagged. This study aimed to investigate the use of MLMs to predict demand on orthopaedic residents to optimize scheduling.

Methods

Daily surgical handover emails over an eight-year (2012–2019) period at a level I trauma centre were used to model demand on residents. Various MLMs were trained to predict the workload, with their results compared to the current approach. Quality of models was determined by using the area under the receiver operator curve (AUC) and accuracy. The top ten most important variables were extracted from the most successful model.

Results

The reduction in orthopaedic resident shifts possible per annum was 24.7%. The most successful model during testing was the neural network (AUC: 0.81, accuracy: 73.7%). All models were better than the current approach (AUC: 0.50, accuracy: 50.1%). Key variables used by the neural network model were (descending order): spine call duty (y/n), year, weekday/weekend, month, and day of the week.

Conclusion

This was the first study using MLMs to predict demand for orthopaedic residents at a major academic institution. All MLMs were more successful than the current scheduling approach. Future work should look to incorporate predictive models with optimization strategies, matching scheduling with demand to improve resident well-being and patient care.
Level of evidence: Level III.
A Comperative study on the efficacy of ksharsutra, fistulectomy and Ligation of intersphincteric fistula tract (LIFT) procedure in the management of fistula in ano.
Authors: Hariprasad Chinniahnapalya Pandurangaiah , Kumar Anil , Kumar Manoj , Kumar Manoj , Paswan Shiv shankar , Rohit Gupta , Kishor Shiv , Kumar Prem
Published: December 2022

Background
Fistula in ano is always a troublesome condition for both the clinician and the patients owing to its complexity, recurrences, and high morbidity since ancient time. There is no gold standard treatment modality till date documented in the literature for complex fistula in ano.
Material and methods
We enrolled 60 consecutive adult patients attending surgical out patient department of tertiary care centre in India, diagnosed with complex fistula in ano. Among them, 20 each in Ligation of Intersphincteric fistula tract, fistulectomy and Ksharsutra group were respectively recruited. The main outcomes were post-operative recurrence and morbidity measured in terms of postoperative pain, postoperative bleeding and pus discharge and post operative incontinence.
Results
The result of the study were analysed after 6 months of follow-up, 2 patients (10%) had a recurrence in Ligation of Intersphincteric fistula tract procedure group and 3 patients (15%) in the fistulectomy group and 6 patients (30%) in Ksharsutra group, however, the differences in the recurrence were not statistically significant, the mean Visual analogue score for pain after 24 hours as well as after 48 hours were statistically significant in Ligation of Intersphincteric fistula tract versus Ksharsutra group (p < 0.05). The Visual analogue score was also significant in the Ligation of Intersphincteric fistula tract versus Fistulectomy group (p < 0.05). The patients treated via Fistulectomy and Ksharsutra had a higher proportion of bleeding (15%) as compared to the Ligation of Intersphincteric fistula tract procedure. Post operative morbidity was statistically significant between Ligation of Intersphincteric fistula tract versus Ksharsutra and Ligation of Intersphincteric fistula tract versus Fistulectomy.
Conclusion
Ligation of Intersphincteric fistula tract had less postoperative morbidity compared to Fistulectomy and Ksharsutra procedure, although recurrence was less compared to other procedures it was statistically not significant.
Analysis of Echocardiographic Findings of Patients with Acute Ischemic Stroke Admitted to a Tertiary Hospital in Mogadishu, Somalia
Authors: Hassan Mohamed Sheikh , Waberi Mohamud Mire , Ahmed Said Abdirahman , Sidow Nor Osman , Akyuz Hakkan , Abdi Ishak Ahmed
Published: December 2022

Background and Aims

Etiological investigation of potential cardiac source of acute ischemic stroke is important for secondary prevention of recurrent and future embolisation. Transthoracic echocardiography is one of the most useful investigations for the assessment of the potential cardiac etiology of ischemic stroke. Our aim is to evaluate echocardiographic findings in patients with acute ischemic stroke admitted in Mogadishu, Somali Turkish Training and Research Hospital.

Methods

The study was retrospective observational study conducted in the neurology department of teaching hospital in Mogadishu, Somalia. The study focused on the assessment of echocardiographic findings of patients with acute ischemic stroke admitted to the neurology ward. The data was retrieved from the electronic records of patients admitted to the neurology department due to acute ischemic stroke. All patients with acute ischemic stroke who had undergone transthoracic echocardiography from March 2019 to March 2022 were enrolled.

Findings

The mean age of patients was 62 ± 12. The majority of the patients in the study were 60 years of age or older 210(66.7%). The male subjects in the study population accounted for 178(56.5%), while females accounted for 137(43.5%). Co-morbidities were present in about 251(80%) of the subjects, hypertension was the most common comorbidity 99(31.4%), followed by diabetes 72(23%), and hyperlipidemia 37(11.7%). Over all cardiac pathology in this study was 54%. 47(15%) of the patients had low ejection fraction on transthoracic echocardiography. Male patients had slightly less left ventricular systolic dysfunction than did female patients. 100(32%) had LVDD while 113(36%) had LVH. Left ventricular hypertrophy was more frequent in hypertensive patients (46% of hypertensive patients). Left ventricular diastolic dysfunction (LVDD) was more common among diabetic patients (60% of diabetic patients). Patient with hypertension and diabetes had more echo abnormalities compared to others (P-value of 0.047 and 0.024 respectively). More echo abnormal findings were seen in patients who died during hospitalization than those who survived. (P = 0.008). Severe LV dysfunction was associated higher mortality (P < 0.001).

Conclusion

Most patients with stroke in this study had abnormal echocardiogram, however few have cardioembolic strokes. Abnormalities in echocardiography were more common in in patients who died during hospitalization than those who survived.
Evolution of Maternity Protection in France: Opportunities for China
Authors:   Shanghai University of Politics and Law, Shanghai, China, Jingjuan Liu
Published: December 2022

The French experience in solving demographic and social problems related to low fertility is based on the study of a wide range of issues ranging from individual reproductive well-being to its socio-cultural conditioning. The study has shown that the system of maternity protection in France uses not only administrative and legal regulation as a direct method, but also a wide range of indirect social welfare mechanisms, aimed at creating a social and cultural environment favorable to motherhood, as well as spreading the idea of maternity protection in all spheres of society development: childbirth becomes not only an individual responsibility, but also the responsibility of family and society. Such practices are important for the implementation of People's Republic of China fertility and population policy, in particular for improving the system of maternity protection by increasing the social value of fertility and creating a balance between the family and work functions of women. The general situation and specific features of French and Chinese systems of maternity protection are analyzed in the article through the prism of identifying effective mechanisms of increasing the population growth rate in China through the implementation of the best practices of the French system of social guarantees, increasing the cultural and social significance of motherhood
ASSESSMENT OF INDUSTRIAL ENTERPRISE SCIENTIFIC POTENTIAL BASED ON THE INTEGRATED APPROACH
Authors:   Transbaikal State University, Chita, Vlasov N., , Palkina E ,   Transbaikal State University, Chita
Published: December 2022

Management of scientific potential is of great importance for the development of knowledge-intensive industries. At the same time, an important functional element in the process of the management cycle is the assessment of the scientific potential of industrial enterprises. The purpose of this study is to develop and substantiate a methodological approach to assessing the scientific potential of an industrial enterprise. The subject of the study is conceptual approaches to the assessment of the scientific potential of a production organization. The object of the study is the scientific potential of an industrial enterprise. Methods of analysis and synthesis, abstraction, generalization and grouping have been used in the course of the study. The article presents the results of the study of the existing basic approaches to the assessment of the scientific potential of the organization. The key aspects of assessing the resources and competencies of a manufacturing enterprise from the perspective of forming its scientific potential are identified. The basic characteristics of the competencies of an industrial enterprise are determined. The features of the application of the competence approach in the management of knowledge-intensive industries are disclosed. A new conceptual approach to the assessment of the scientific potential of an industrial enterprise is proposed on the basis of integrated accounting of the resources available to the production organization for the implementation of economic activities and the competencies formed for their effective use in modern market conditions. The sequence of stages of the search for the competencies of the enterprise based on its competitive advantages is established. The final stage of the search sequence is the compilation of competence maps, which act as a tool for the diffusion of competencies within the enterprise or exchange with external business partners. The possibility of using benchmarking and creating benchmarking groups for the exchange of competencies between enterprises is indicated. Methodological provisions for assessing the scientific potential of an industrial enterprise based on an integrated approach have been developed
Cornered Islamic Society: A Critical Discourse Analysis on Islamophobic Memes
Authors: Putra Rizky Anugrah
Published: December 2022

In the era before the internet, memes could take the form of posters containing messages, invitations, and even propaganda. Propagandists manipulated those discourses and presented them at public events such as theatres and festivals. It has evolved into computational propaganda using media and popular memes in the modern era. Muslims are effortless targets for offensive memes, which have been going on for the last decade. This prejudice has become a familiar issue for internet users and vandalizes the image of Muslims and links Muslims to all social problems that transpire in society. This study examined Islamophobic theme memes transmitted on international memetic sites. Popular Islamophobic memes were analyzed using critical discourse analysis to break down the phenomenon based on visual, textual, and social motives. The findings demonstrated that the meme creators utilized the hottest issue to induce the ill idea of demonizing Muslim society and tend to alter the information in their favour. Memes with Islamophobia discourse often included provocative sentences that satirize the teachings of Islam accompanied by words that collocate with aspects of terror, terrorism, radical, extremism, violence, and abuse. That discourse influenced opinions and damaged the image of the target meme, and this method was remarkably efficacious, as evidenced by a large amount of support obtained on anonymous sites. In addition, this meme was distributed in anonymous forums, where this forum ensured the privacy of the meme's sender without worrying that his insults in cyberspace would affect the real world.
SUSTENTABILIDADE NO USO DE FÓSFORO: UMA REVISÃO BIBLIOGRÁFICA COM FOCO NA SITUAÇÃO ATUAL DO ESTADO DE SÃO PAULO, BRASIL
Authors: Sasabuchi Isabela , Krieger Kamille , Nunes Renan , Ferreira Amanda , Xavier Gabriela , Urzedo Alessandro , Carvalho Wagner , Fadini Pedro
Published: December 2022

SUSTAINABILITY IN PHOSPHORUS USE: A BIBLIOGRAPHIC REVIEW FOCUSING ON THE CURRENT SITUATION IN THE STATE OF SÃO PAULO, BRAZIL. Phosphorus is a non-renewable element essential for the existence of life and also for food security. This resource has the property of limiting plant growth, becoming a fundamental part of agricultural production. On the other hand, when this element is present in high concentrations in aquatic environments, it can start a phenomenon called eutrophication, which causes a series of changes in biological succession processes and strongly negative impacts on species’ biodiversity and wealth. In this context, this work aimed, from an extensive bibliographical review, to gather strategic and essential information related to phosphorus sustainability, provoking a reflection regarding scenarios that involve this indispensable nutrient, focusing on the current situation of the State of São Paulo, Brazil, an important case study, both for the Brazilian and international scenario, by a gathering of data on the current situation of two of the main watersheds in the corresponding region. Relevant technologies used for phosphorus removal in eutrophicated environments are also addressed. Finally, the possibility of reusing the nutrients present in eutrophicated water bodies as an alternative source of phosphate fertilizer for agriculture is demonstrated.
DETERMINAÇÃO DE FOSFATIDILETANOL EM MANCHAS DE SANGUE SECO EM PAPEL POR UHPLC-MS/MS: AVALIAÇÃO DO CONSUMO DE ÁLCOOL EM DEPENDENTES QUÍMICOS
Authors: Tegner Mariane , Guterres Fernanda , Ott Isabela , da Motta Lidiane , Schmitz Deise , Perassolo Magda , Linden Rafael , Antunes Marina
Published: December 2022

DETERMINATION OF PHOSPHATIDYLETANOL IN DRIED BLOOD SPOT BY UHPLC-MS/MS: EVALUATION OF ALCOHOL CONSUMPTION IN CHEMICAL DEPENDENTS. We developed and validated an UHPLC-MS/MS method for the quantification of phosphatidylethanol (PEth) in dried blood spots (DBS). Sample preparation was a liquid extraction and chromatographic separation was performed in an Acquity C8 column. The mobile phases were 4 mM ammonium acetate in water (A) and acetonitrile (B) at 24:76 (v/v). The total analytical run time was 6 minutes, with retention time of 3.36 min for PEth and 4.13 min for phosphatidylpropanol. The method was linear from 10 to 3000 ng mL-1, specific, with, precise and accurate. The analyte was stable in DBS stored from -20 to 45 °C for 21 days. Matrix effect was compensated with the internal standard (-5.21% to + 6.09%). The method was applied in the evaluation of alcohol consumption in DBS from 25 chemical dependents. The PEth concentrations ranged from 14.5 to 2380.8 ng mL-1, with significant correlation with the self-report alcohol consumption AUDIT scores (r=0.41).
Decoding Delhi's water governance through multi-level governance approach
Authors: Kumari Savitri , Biswas Rabidyuti
Published: December 2022

This article explores the intertwined, multi-level, and varied scale of public institutions, local level organizations, and various actors involved in rendering water supply services to the residents of Delhi. To ensure water security in the national capital, the study of actors and institutions involved in the water governance of Delhi is pertinent. Delhi, being the capital of the country, has overlapping administration between both the central and state government. Various ministries and departments which vary in hierarchy and power are working for the day-to-day functioning of the megacity. This phenomenon also applies to the water governance of Delhi, making it byzantine and complex in nature. In this context, a multi-level governance approach has been used for exploring the water governance of Delhi. Identification of various actors, stakeholders, and institutions involved in Delhi's water governance is a prerequisite to ensure effective, equitable, and participatory water management for the city.
Hybrid wavelet-gene expression programming and wavelet-support vector machine models for rainfall-runoff modeling
Authors: Lakshmi Potharlanka Jhansi , Apaza Rubén Apaza , Alkhayyat Ahmed , Marhoon Haydar Abdulameer , Alameri Ameer A.
Published: December 2022

It is critical to use research methods to collect and regulate surface water to provide water while avoiding damage. Following accurate runoff prediction, principled planning for optimal runoff is implemented. In recent years, there has been an increase in the use of machine learning approaches to model rainfall-runoff. In this study, the accuracy of rainfall-runoff modeling approaches such as support vector machine (SVM), gene expression programming (GEP), wavelet-SVM (WSVM), and wavelet-GEP (WGEP) is evaluated. Python is used to run the simulation. The research area is the Yellow River Basin in central China, and in the west of the region, the Tang-Nai-Hai hydrometric station has been selected. The train state data ranges from 1950 to 2000, while the test state data ranges from 2000 to 2020. The analysis looks at two different types of rainy and non-rainy days. The WGEP simulation performed best, with a Nash-Sutcliffe efficiency (NSE) of 0.98, while the WSVM, GEP, and SVM simulations performed poorly, with NSEs of 0.94, 0.89, and 0.77, respectively. As a result, combining hybrid methods with wavelet improved simulation accuracy, which is now the highest for the WGEP method.
Teorías Subjetivas respecto del apoyo percibido del profesor en estudiantes secundarios
Authors:   Universidad de Atacama, Rubio González Juan José , David Jorge David Jorge ,   Universidad de Atacama
Published: December 2022

El estudio se propuso describir e interpretar las Teorías Subjetivas de estudiantes de nivel secundario, en torno al apoyo percibido del profesor. Para ello, se trabajó desde un enfoque mixto, donde la fase cuantitativa, utilizando la Red Semántica Natural, posibilitó la configuración de los principales conceptos asociados al Apoyo del Profesor –AP-, mientras que desde lo cualitativo se asume la lógica del estudio de caso para comprender las significaciones subjetivas realizadas por los estudiantes respecto al tema. Así, escuchar, emerge como el concepto central con mayor peso semántico asociado al AP, en tanto las Teorías Subjetivas de los estudiantes van en la línea de significar, establecer factores que obstaculizan y propician el AP, configurar acciones de desarrollo y tipos de AP, así como sugerencias que permitan una práctica adecuada. Se discute y concluye sobre la relevancia de figura del profesor en el contexto educativo, como agente que propicia interacciones positivas y vínculos afectivos con los estudiantes, que actuaría como factores protectores contra una diversidad de fenómenos del ámbito escolar.
Increasing Prevalence of Methicillin-resistant Staphylococcus aureus among Hospital and Community acquired Infections in Khartoum State, Sudan
Authors: Elhassan Mogahid M. , Hamdan Elsadig M. , Hassan Asmaa A , Amin Safa A. , Ahmed Hiba A. , Ataelmanan Amany E. , Elmakki Miskelyemen A.
Published: December 2022

Background:

Staphylococcus aureus is an important bacterium that can cause many diseases. Methicillin-resistant S.aureus (MRSA) is often sub-categorized as Hospital or Community acquired infection. MRSA causes serious problems, such as bloodstream and surgical site infections or pneumonia.

Objectives:

The present study aimed to identify S. aureus by 16SrRNA using PCR, estimate the antibiotic susceptibility pattern and determine the prevalence of MRSA among Hospital and community acquired infections.

Methods:

A cross-sectional laboratory-based study was conducted during the period from November 2020 to January 2021. Conventional methods were used to identify S. aureus and isolate confirmation was performed by PCR targeting 16SrRNA gene. All isolated organisms were tested for their in-vitro antimicrobial susceptibility.

Result:

Among the enrolled patients (n, 300), MRSA was observed in 185 (61.7%). The highest frequency was shown in the age group over 45 years old (46.7%). The result also showed a high frequency of S. aureus among community infections (81.7%), MRSA in hospital acquired infections was 10.7% while 51% was community acquired. The antimicrobial susceptibilities against MRSA isolates showed high sensitivity to Ceftriaxone 90.0%). Most infections caused by MRSA isolates were respiratory tract infection (RTI) (28.3%) and Septicemia (22.5%).

Conclusion:

The present study highlighted a high proportion of MRSA in clinical settings at Khartoum State. Antibiotic susceptibility results showed that Ceftriaxone was the drug of choice against MRSA isolates. Overuse and misuse of antibiotics, along with self-medication, seem to be the cause of antibiotic resistance, thus should be avoided.
Stability Charts for Limiting Horizontal Normal Pressure on Cohesive-frictional Backfill for Deep Contiguous Piled Walls
Authors: Keawsawasvong Suraparb , Kumar Jyant , Banyong Rungkhun , Sangjinda Kongtawan
Published: December 2022

Background:

This study presents a numerical solution for determining the limiting uniform normal pressure acting horizontally behind cohesive-frictional backfill material in a deep contiguous piled wall. At this limiting pressure, the soil tends to flow out in gaps between a series of vertical piles placed at a certain uniform horizontal spacing.

Methods:

The lower and upper bound plane strain finite element limit analysis (FELA) has been carried out for this purpose. The Mohr-Coulomb failure criterion, using an associated flow rule, was employed to impose the yield condition in the soil mass.

Results:

A parametric study was carried out to obtain the magnitude of the non-dimensional limiting lateral resistance (F/cD) as a function of normalized pile spacing (S/D), the friction angle of soils (ϕ), and the adhesion factor (δ) at the soil-pile interface; here,Frefers to the lateral normal resistance (force) per unit length offered by the pile,Sforms the clear spacing between piles,Dis the diameter of the pile andcis soil cohesion. The impact of the different parameters on the failure mechanisms has been examined comprehensively.

Conclusion:

The lateral resistance (F/cD) offered by the piles increases generally with a decrease in the spacing between the piles. The magnitude ofF/cDincreases further with an increase in the values ofϕandδ.