bluuebunny/crossref_metadata_2025 huggingface dataset:
The Magnitude of Common Mental Disorders and Associated Factors Among Cancer Patients at Black Lion Specialized Hospital, Addis Ababa, Ethiopia: Cross- Sectional Study
Authors: Feyera Fetuma , Endeshaw Mulualem , Kebede Yigzaw , Tirfessa Kebede , Bekele Simeneh Belay
Published: September 2022

Background

Common mental disorders (CMD) are the most usual reactions following cancer diagnosis causing significant psychological sufferings. Even though research-based evidence is necessary for mental health promotion and intervention activities, there is a scarcity of evidence in Ethiopia to assist policy makers’ efforts in reforming mental health care particularly that of cancer patients.

Objective

The main objective of this research is to assess the magnitude of common mental disorders and associated factors among cancer patients who have a follow-up treatment at Black Lion Specialized Hospital, Addis Ababa, Ethiopia.

Method

Institutional-based cross-sectional study was conducted from August 1 to September 30, 2020. A systematic random sampling technique was used to select 396 study participants. A Self-Reporting Questionnaire (SRQ-20) and interviewer-administered structured questionnaire were employed to collect data. Data were analyzed using descriptive statistics and logistic regression. Odds ratios with 95% confidence intervals was used to report the findings.

Result

A total of 396(230 men and 160 women) participants took part in the study. The overall magnitude of CMD among cancer patients was found to be 70.3%, of which the rate was 73.5% among women and 67.8% among men, in the last 4 weeks. Being women (AOR = 1.74; 95%CI: 1.00, 3.02), unemployed (AOR = 3.035, 95% CI: 1.37, 6.72), average monthly income of less than 1600 Ethiopian Birr (AOR = 2.838; 95%CI: 1.58, 5.08), being on cancer treatment for more than 5 years (AOR = 2.653, 95% CI: 1.39, 5.03), poor social support (AOR = 3.618, 95% CI: 1.33, 9.80), and current use of substances (AOR = 6.852; 95% CI: 2.038, 23.034) were the factors significantly associated with CMD.

Conclusion and recommendation

Common mental disorders are one of the major health concerns among cancer patients. Common mental disorders were found to be more common in females and among current users of a psychoactive substance. Therefore, cancer patients need special attention of not only physicians but also that of mental health professionals for possible detection and early treatment of mental disorders. Rendering social and economic support may reduce the negative effects of the illness.
Are Home Evictions Associated with Child Welfare System Involvement? Empirical Evidence from National Eviction Records and Child Protective Services Data
Authors: Tang Shichao , Bowen Daniel A , Chadwick Laura , Madden Emily , Ghertner Robin
Published: September 2022

This study aimed to understand the relationship between home eviction and child welfare system involvement at the county level. Using administrative data, we examined associations of home eviction and eviction filing rates with child abuse and neglect (CAN) reports and foster care entries. We found one additional eviction per 100 renter-occupied homes in a county was associated with a 1.3% increase in the rate of CAN reports and a 1.6% increase in foster care entries. The association between eviction and foster care entries was strongest among Hispanic children with an 8.1% increase. Assisting parents in providing stable housing may reduce the risk of child welfare system involvement, including out-of-home child placement. Primary and secondary prevention strategies could include housing assistance, increasing access to affordable and safe housing, as well as providing economic support for families (e.g., tax credits, childcare subsidies) that reduce parental financial burden to access stable housing.
The Effect of Positive Psychotherapy-Based Training on Stigma and Self-Efficacy in Women Receiving Infertility Treatment
Authors: Yanık Derya , Kavak Budak Funda
Published: September 2022

Background:

Infertility has increased in recent years. Infertility can cause many mental problems. The place of psychoeducation based on positive psychotherapy (PPT) is important in coping with mental problems.

Aims:

The aim of this study is to determine the effect of PPT-based training on stigma and self-efficacy in women receiving infertility treatment.

Methods:

This experimental study with randomized control group was completed with 64 women receiving infertility treatment. While the women in the experimental group received an 8-session PPT-based training, no intervention was applied to those in the control group.

Results:

A statistically significant difference was observed ( p= .001) between the stigma and self-efficacy levels of the experimental group after the PPT-based training.

Conclusions:

It was found that the PPT-based training was effective in decreasing stigma level of the women who received infertility treatment and increasing their self-efficacy level.
“Busy idleness”: The active and moral dimension of boredom
Authors: Johnsen Rasmus
Published: September 2022

In this essay, I argue for the value of studying boredom as a social and organizational phenomenon. Recently, an interest in the more active side of boredom has led to the publication of a number of popular psychology books on boredom’s motivational capacities. A key point in this literature is the focus on the individual ability to distinguish between activity and productivity, and to exploit boredom for self-development purposes. I argue that this trend in boredom studies should prompt us to look closer, not only at the moral history of boredom, and at how social reality has organized around it, but also on what boredom, and the countermeasures it represents, “produce” as a central experiential component of alienated labor.
Boredom at work: The contribution of Ernst Jünger
Authors: Watt Peter , Weibull Fredrik
Published: September 2022

This paper interrogates the phenomenon of boredom at work by considering Ernst Jünger’s potential contribution. We contend that Jünger offers an important yet overlooked alternative to the dominant perspectives of boredom in Management and Organization Studies (MOS), which are largely composed of ‘simple’ psychological diagnoses and managerial prescriptions. Such studies largely understand boredom as a localised experience at work which can be overcome by targeted managerial prescriptions, techniques and interventions. In contrast we show how Jünger understands boredom from a ‘profound’ perspective as a central feature of modernity. This is premised on Jünger’s broader critique of the bourgeois values that define 20th and 21st century managerial work and organization. Jünger’s cultural-historical perspective is therefore aligned to the discrete field of Boredom Studies. By addressing how Jünger understands ‘work’ as the defining feature of the modern age, his critique situates the phenomenon of boredom at work within the broader social, institutional and cultural order of the 21st Century. While Jünger does not set out to provide a theory of boredom as such, we reconstruct such a theory through an exegesis of his writing on ‘work’ and ‘danger’. This reveals boredom and danger as phenomenologically intertwined concepts, which is an understanding of boredom that has not been considered in MOS or Boredom Studies. It is through this, we argue, that Jünger’s conception of work holds the potential for a powerful critique and understanding of boredom at work under the contemporary regime of neoliberal managerialism.
In praise of boredom at work
Authors: Noury Lucie , Ahuja Sumati , Parker Martin , Sturdy Andrew , Tyler Melissa
Published: September 2022

In the context of management and organisational literature, boredom has largely been seen in individual, psychological and negative terms, both for those experiencing it and for organisational outcomes. Through selective references to a wider sociological, historical and philosophical set of perspectives, we make a case here for refiguring boredom at work as a more relational and political notion. Rather than being seen as negative or trivial, we suggest that it is central to the concerns of organisation studies (and more widely) as a ambivalent everyday condition and experience. In particular, boredom is intimately linked to the project and promises of modernity and its associated effects on time, from factory industrialisation to contemporary work platforms. Both in terms of philosophical argument and applied fields such as art, literature, architecture and design, we suggest that boredom is both emancipatory/productive and alienating. Such an understanding establishes opportunities for research which would be central to the experience of contemporary paid employment and wider experience.
Ageism in job interviews: Discreet ways of building co-membership through age categorisation
Authors: Previtali Federica , Nikander Pirjo , Ruusuvuori Johanna
Published: September 2022

This article investigates how age categorisation and prejudicial use of age are mobilised in talk by job applicants during job interviews and how recruiters affiliate with these. The institutional goal of recruitment is to ensure an unbiased process and evaluation, nevertheless, ageism against older workers emerges as unchallenged and culturally acceptable in authentic job interviews. In line with the discursive psychology (DP) approach, the analysis focuses on -isms as discursively constructed and categories as resources to accomplish social actions. A case study is conducted based on video recordings of 24 real job interviews held at an Italian staffing agency and analysed through membership categorisation and conversation analysis. The analysis provides evidence of how job applicants resort to age co-membership with recruiters to achieve affiliation – or remedy misalignment – by complaining about older workers. The study contributes to DP’s re-specification of prejudices as interactional practices and links microanalysis to macro phenomena, such as ageism, through categorisation practices.
Surface interactions of model microplastic particles in seawater
Authors: Abdul Rahman Amir Muhammad Noh Amin , Yan Lim Zhan , Abdul Hamid Zuratul Ain , Ku Ishak Ku Marsilla , Abdullah Muhammad Khalil , Rusli Arjulizan , Khimi Shuib Raa , Mohd Zaini Makthar Muaz , Shafiq Mohamad Danial
Published: September 2022

Microplastic is classified as fragmented polymeric particles up to 500 microns in diameter. In an aqueous system, microplastic does not always present as a single particle, and these microparticles tend to aggregate and subsequently causing severe ecological risks. The exploration of the underlying mechanisms on how microplastics aggregate in seawater and freshwater enables the prediction of their diffusivity, distribution, and bioavailability in the water environment. In this study microplastic model systems of polypropylene (PP) and poly(vinyl chloride) (PVC) were used to investigate the interactions and aggregation size between microplastics in seawater and with the response anionic sodium dioctyl sulfosuccinate (AOT) surfactant dosages via electrophoretic mobility and Dynamic Light Scattering (DLS) measurements, supported by the UV-Vis spectrum analysis. This investigation revealed that mobile ions present in water ecosystems played a vital role in the surface interactions between microplastics and their aggregation behaviour. The surface charge of both PP and PVC microplastics were switched to a positive value at 5 wt.% of AOT and continued in the negative regime with increasing AOT concentration. Upon the addition of surfactant, surface charge neutralization and aggregation of PP and PVC microplastics were detected; however, the restabilization of microplastic was observed with increasing concentration of surfactant.
Generative workplace and space planning in architectural practice
Authors: Okhoya Victor W , Bernal Marcelo , Economou Athanassios , Saha Nirvik , Vaivodiss Robert , Hong Tzu-Chieh K , Haymaker John
Published: September 2022

Generative design is emerging as an important approach for design exploration and design analysis in architectural practice. At the interior design scale, although many approaches exist, they do not meet many requirements for implementing generative design in practice. These requirements include the need for end-user accessible tools and skills, rapid execution, the use of standard inputs and outputs, and being scalable and reusable. In this paper, we describe a hybrid process that uses both space allocation and shape grammar algorithms to solve workplace and space planning interior design problems. Space allocation algorithms partition spaces according to program requirements while shape grammar automates the placement of inventory and the production of high-resolution drawings. We evaluate using three real world example projects how this hybrid approach meets the identified requirements of generative space planning in architectural practice.
Influences of COVID-19 pandemic and the states of emergency on occupational therapy for physical disorders: A questionnaire survey in Hokkaido, Japan
Authors: Saito Hidekazu , Yokoyama Kazuki , Morimoto Takafumi , Ota Hisaaki , Ikeda Nozomu
Published: September 2022

Objective: This study aimed to explore the influence of coronavirus disease-2019 (COVID-19) on occupational therapy (OT) for physical disorders, including changes in the assessment, treatment, other restrictions, and measures of OT.

Methods: A questionnaire survey was conducted among occupational therapists working in Hokkaido, Japan, and 123 out of the 334 (36.8%) were from OT facilities that target physical disorders. The responses were classified the categories and codes by [ ] and < >, respectively.

Results: The number of patients decreased in 47.1% of the OT facilities after the pandemic declaration. Only one facility reported . Therefore, [thoroughness of standard precautions] including , , and [changes in treatment structure] including  were implemented. Additionally, there were not only [restrictions on participation of patients] and [restrictions on outpatient services], but also [restrictions on operations of OT], such as  and so on. Furthermore, [changes in treatment structure] and [setting criteria for discontinuation of participation] were utilized in some facilities to prevent and to reduce the risk of infection.

Conclusions: By revisiting the assessment and treatment guidelines on infection control, it is possible to provide continuous OT services and to tackle the challenges posed by the pandemic.
Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating Hyperkeratosis and Sebum Secretion
Authors: Zhu Yuyan , Zhang Lixia , Zhou Xiyuan
Published: September 2022

The prevalence of acne vulgaris is high, but the topical retinoids used as the foundation of treatment have teratogenic and photosensitivity properties. Previous studies have suggested that honokiol, a small-molecule compound extracted from Magnolia officinalis, could effectively inhibit Cutibacterium acnes ( C acnes) and inflammation in vitro. However, the effect in vivo is unclear. The rabbit ear acne model that we created showed obvious comedones and hyperkeratosis. These lesions were repeatedly measured and recorded by dermatoscopy (ultraviolet light). Compared with the control group, topical 2.5% honokiol cream obviously improved the comedones and hyperkeratosis and effectively reduced sebum secretion, as shown by Oil Red O staining. The effects were equivalent to those of adapalene gel without local side effects. We added honokiol's other functions to acne treatment in addition to antiinflammation, but further studies are needed.
Separation from the (Evil) World: 2 Timothy 2.19-21 and the Plymouth Brethren Christian Church
Authors: Church Philip
Published: September 2022

Separation from the (evil) world based on 2 Tim 2.19-21 is a defining characteristic of exclusive brethrenism, both in its most extreme form, the Plymouth Brethren Christian Church, and in other exclusive brethren groups. I examine this text in its context and then critically assess John Nelson Darby’s reading of it, working from his translation and his comments elsewhere in his writings. Darby misread the text as separation from “evil people” rather than avoidance of wrongdoing, with disastrous consequences. I conclude with some reflections on how his reading of v. 19 arose and on the dangers associated with translation work undertaken by influential individuals working in isolation from other scholars.
Effects of a postoperative program in patients with shoulder stiffness following arthroscopic rotator cuff repair
Authors: Gutiérrez-Espinoza Héctor , Araya-Quintanilla Felipe , Pinto-Concha Sebastián , Sepúlveda-Loyola Walter , Ramírez-Vélez Robinson , Fuentes-Contreras Jorge
Published: September 2022

Background

The most common complication in the surgery for rotator cuff (RC) tears is postoperative shoulder stiffness. The evidence for the postoperative treatment of this condition is scarce. This study assessed the effects of a postoperative program at the onset of shoulder stiffness following arthroscopic RC repair.

Methods

A single-group pre- and post-test design was included. Participants performed a 6-week program. Primary outcomes were shoulder and upper limb function assessed with the Constant–Murley and Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaires, respectively. Secondary outcomes included pain intensity at rest and during movement with the visual analog scale (VAS), and shoulder range of motion assessed with a goniometer.

Results

A total of 115 adult males were included. The intervention produced a positive effect on the Constant–Murley (+35.6 points, p<0.001) and DASH questionnaire (−26.2 points, p = 0.005); VAS at rest (−2.8 cm, p<0.001); VAS at movement (−2.7 cm, p<0.001); and shoulder ROMs.

Conclusion

The program showed clinically and statistically significant benefits in most of the functional outcomes in the study participants.
Hip Labral Reconstruction With a Polyurethane Scaffold: Restoration of Femoroacetabular Contact Biomechanics
Authors: Capurro Bruno , Reina Francisco , Carrera Anna , Monllau Joan Carles , Marqués-López Fernando , Marín-Peña Oliver , Torres-Eguía Raúl , Tey-Pons Marc
Published: September 2022

Background:

Many advances have been made in hip labral repair and reconstruction and in the restoration of the suction seal.

Purpose/Hypothesis:

The purpose of this study was to evaluate the biomechanical effects of segmental labral reconstruction with a synthetic polyurethane scaffold (PS) in comparison with segmental labrectomy. Our hypothesis was that reconstruction with a icroporous polyurethane implant would normalize joint kinetics of the hip and restore the suction seal.

Study Design:

Controlled laboratory study.

Methods:

We used 10 hips from 5 fresh-frozen pelvises with an intact acetabular labrum without osteoarthritis. Using an intra-articular pressure measurement system, the contact area, contact pressure, and peak force were assessed for the following conditions: intact labrum, partial anterosuperior labrectomy, and PS reconstruction. For each condition, all specimens were analyzed in 4 positions (90° of flexion, 90° of flexion and internal rotation, 90° of flexion and external rotation, and 20° of extension) and underwent a labral seal test. The relative change from the intact condition was determined for all conditions and positions.

Results:

Compared with the intact labrum, labrectomy resulted in a significant decrease in the contact area ( P < .001) and a significant increase in the peak force ( P < .001) and contact pressure ( P < .001) across all positions. Compared with labrectomy, PS reconstruction resulted in a significant increase in the contact area ( P < .001) and a significant decrease in the contact pressure ( P ≤ .02) and peak force ( P < .001) across all positions. Compared with the intact labrum, PS reconstruction restored the contact area and peak force to normal values in all positions ( P > .05), whereas the contact pressure was significantly decreased compared with labrectomy ( P < .05) but did not return to normal values. The labral seal was lost in all specimens after labrectomy but was restored in 80% of the specimens after PS reconstruction.

Conclusion:

Femoroacetabular contact biomechanics significantly worsened after partial labrectomy; reconstruction using a PS restored the contact area and peak force to the intact state and improved the contact pressure increases seen after partial labrectomy. The contact area and peak force were normalized, and the labral seal was re-established in most cases.

Clinical Relevance:

This study provides biomechanical evidence for the use of a scaffold for labral reconstruction.
Effect of Anterior Horn Tears of the Lateral Meniscus on Knee Stability
Authors: Shiwaku Kousuke , Kamiya Tomoaki , Otsubo Hidenori , Suzuki Tomoyuki , Nabeki Shogo , Yamakawa Satoshi , Okada Yohei , Teramoto Atsushi , Watanabe Kota , Iba Kousuke , Fujie Hiromichi , Yamashita Toshihiko
Published: September 2022

Background:

Investigations on the biomechanical characteristics of the anterior horn of the lateral meniscus (AHLM) related to anterior cruciate ligament (ACL) tibial tunnel reaming have revealed increased contact pressure between the femur and tibia, decreased attachment area, and decreased ultimate failure strength.

Purpose/Hypothesis:

The purpose of this study was to investigate the influence of a complete radial tear of the AHLM on force distribution in response to applied anterior and posterior drawer forces and internal and external rotation torques. We hypothesized that the AHLM plays an important role in knee stability, primarily at lower knee flexion angles.

Study Design:

Controlled laboratory study.

Methods:

A total of 9 fresh-frozen cadaveric knee specimens and a robotic testing system were used. Anterior and posterior drawer forces up to 89 N and internal and external rotation torques up to 4 N·m were applied at 0°, 30°, 60°, and 90° of knee flexion. A complete AHLM tear was then made 10 mm from the lateral border of the tibial attachment of the ACL, and the same tests performed in the intact state were repeated. Next, the recorded intact knee motion was reproduced in the AHLM-torn knee, and the change in the resultant force after an AHLM tear was determined by calculating the difference between the 2 states.

Results:

In the torn AHLM, the reduction in the resultant force at 0° for external rotation torque (34.8 N) was larger than that at 60° (5.2 N; P < .01) and 90° (6.7 N; P < .01).

Conclusion:

The AHLM played a role in facilitating knee stability against an applied posterior drawer force of 89 N and external rotation torque of 4 N·m, especially at lower knee flexion angles.

Clinical Relevance:

This study provides information about the effects of AHLM injuries that may occur during single-bundle ACL reconstruction using a round tunnel.
O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy
Authors: Lu Qingsong , Zhang Xiaozhen , Liang Tingbo , Bai Xueli
Published: September 2022

O-linked β-d-N-acetylglucosamine (O-GlcNAc) is an important post-translational modification of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all animals and plants. In eukaryotes, only two conserved enzymes are involved in this process.O-GlcNAc transferase is responsible for addingO-GlcNAc to proteins, whileO-GlcNAcase is responsible for removing it. AberrantO-GlcNAcylation is associated with a variety of human diseases, such as diabetes, cancer, neurodegenerative diseases, and cardiovascular diseases. Numerous studies have confirmed thatO-GlcNAcylation is involved in the occurrence and progression of cancers in multiple systems throughout the body. It is also involved in regulating multiple cancer hallmarks, such as metabolic reprogramming, proliferation, invasion, metastasis, and angiogenesis. In this review, we first describe the process ofO-GlcNAcylation and the structure and function ofO-GlcNAc cycling enzymes. In addition, we detail the occurrence ofO-GlcNAc in various cancers and the role it plays. Finally, we discuss the potential ofO-GlcNAc as a promising biomarker and novel therapeutic target for cancer diagnosis, treatment, and prognosis.
Genome-wide characterization of the MBF1 gene family and its expression pattern in different tissues and stresses in Zanthoxylum armatum
Authors: Hui Wenkai , Zheng Hao , Fan Jiangtao , Wang Jingyan , Saba Tahseen , Wang Kai , Wu Jiaojiao , Wu Han , Zhong Yu , Chen Gang , Gong Wei
Published: September 2022

Background

Multiprotein bridging factor 1 (MBF1) is a crucial transcriptional coactivator in animals, plants, and some microorganisms, that plays a necessary role in growth development and stress tolerance. Zanthoxylum armatum is an important perennial plant for the condiments and pharmaceutical industries, whereas the potential information in the genes related to stress resistance remains poorly understood in Z. armatum. 

Results

Herein, six representative species were selected for use in a genome-wide investigation of the MBF1 family, including Arabidopsis thaliana, Oryza sativa, Populus trichocarpa, Citrus sinensis, Ginkgo biloba, and Z. armatum. The results showed that the MBF1 genes could be divided into two groups: Group I contained the MBF1a and MBF1b subfamilies, and group II was independent of the MBF1c subfamily.. Most species have at least two different MBF1 genes, and MBF1c is usually an essential member. The three ZaMBF1 genes were respectively located on ZaChr26, ZaChr32, and ZaChr4 of Zanthoxylum chromosomes. The collinearity were occurred between three ZaMBF1 genes, and ZaMBF1c showed the collinearity between Z. armatum and both P. trichocarpa and C. sinensis. Moreover, many cis-elements associated with abiotic stress and phytohormone pathways were detected in the promoter regions of MBF1 of six representative species. The ERF binding sites were the most abundant targets in the sequences of the ZaMBF1 family, and some transcription factor sites related to floral differentiation were also identified in ZaMBF1c, such as MADS, LFY, Dof, and AP2. ZaMBF1a was observed to be very highly expressed in 25 different samples except in the seeds, and ZaMBF1c may be associated with the male and female floral initiation processes. In addition, expression in all the ZaMBF1 genes could be significantly induced by water-logging, cold stress, ethephon, methyl jasmonate, and salicylic acid treatments, especially in ZaMBF1c.

Conclusion

The present study carried out a comprehensive bioinformatic investigation related to the MBF1 family in six representative species, and the responsiveness of ZaMBF1 genes to various abiotic stresses and phytohormone inductions was also revealed. This work not only lays a solid foundation to uncover the biological roles of the ZaMBF1 family in Z. armatum, but also provides some broad references for conducting the MBF1 research in other plants.
Acceptability of injectable pre-exposure prophylaxis among people who inject drugs in three urban U.S. settings
Authors: King Adrian R. , Shah Saanchi , Randall Laura A. , Frew Paula M. , Spaulding Anne ,   HBOU Study Team, Holloway Ian W.
Published: September 2022

Background

Outbreaks of new HIV transmission among people who inject drugs (PWID) are a major public health concern. Oral daily PrEP, has been identified as a critical addition to the biomedical toolkit for this population. However, limited research on the acceptability of long-acting injectable PrEP has been conducted with this population.

Methods

We conducted a cross sectional multi-site survey with 1127 participants from May 2019–February 2020 to assess the acceptability of novel PrEP regimens. We computed bivariate and multivariable logistic regressions to evaluate correlates of the outcome variable: acceptability of 3-month injectable-PrEP. SAS v.9.4 was used to conduct statistical analysis.

Results

Limited knowledge of or use of PrEP, past or present, was evident within the sample. Injection drug use in the past six months was significantly associated with LA injectable PrEP acceptability, with the odds of acceptability being 1.885 (CI: 1.376, 2.582) times greater than those who did not inject drugs. After adjusting for confounders, injection drug use was significantly associated with the outcome, such that the odds of acceptability of LA injectable PrEP were 1.705 (CI: 1.198, 2.427) times greater among PWID compared to those who did not inject drugs (p < 0.03). The results demonstrate acceptability (38.2%) in a durable (3-month) injectable PrEP modality among participants who also identified as PWID.

Conclusions

PrEP promotion efforts among PWID to increase access to long-acting injectable PrEP are necessary. Through efforts to increase acceptance and regular use of long-acting injectable PrEP, public health strategies may be able to effectively lessen chances of future HIV outbreaks among PWID.
Response to SARS-CoV-2 vaccines in patients receiving B-cell modulating antibodies for renal autoimmune disease
Authors: Arnold Frederic , Huzly Daniela , Tanriver Yakup , Welte Thomas
Published: September 2022

Background

Effective SARS-CoV-2 vaccination in patients receiving treatment with B-cell depleting agents is challenging. Information on vaccination responses in these patients are a valuable tool to develop efficient vaccination regimens.

Methods

In this single-center retrospective observational study, we report the humoral and cellular response in 34 patients receiving anti-CD20 antibody treatment for renal immune disease.

Results

After base immunization with SARS-CoV-2-vaccines, 92.0% developed a cellular, 32.4% a humoral response. Humoral immunity correlated with B-cell counts and the timespan between anti-CD20 antibody treatment and vaccination. All patients with > 21/µl B-cells, or > 197 days after treatment showed humoral response.

Conclusions

Adequate timing of SARS-CoV-2-vaccinations after anti-CD20 antibody treatment and CD19 measurements are crucial to generate immunity. Awaiting partial B-cell recovery by postponing regularly scheduled anti-CD20 treatment should be considered in patients with stable immune disease.

Trial registration: This study has been retrospectively registered in the German Clinical Trials Register (DRKS00027049) on 29/10/2021.
Application of mammography-based radiomics signature for preoperative prediction of triple-negative breast cancer
Authors: Ge Shuai , Yixing Yu , Jia Dong , Ling Yang
Published: September 2022

Objective

This study is aimed to explore the value of mammography-based radiomics signature for preoperative prediction of triple-negative breast cancer (TNBC).

Materials and methods

Initially, the clinical and X-ray data of patients (n = 319, age of 54 ± 14) with breast cancer (triple-negative—65, non-triple-negative—254) from the First Affiliated Hospital of Soochow University (n = 211, as a training set) and Suzhou Municipal Hospital (n = 108, as a verification set) from January 2018 to February 2021 are retrospectively analyzed. Comparing the mediolateral oblique (MLO) and cranial cauda (CC) mammography images, the mammography images with larger lesion areas are selected, and the image segmentation and radiomics feature extraction are then performed by the MaZda software. Further, the Fisher coefficients (Fisher), classification error probability combined average correlation coefficients (POE + ACC), and mutual information (MI) are used to select three sets of feature subsets. Moreover, the score of each patient’s radiomics signature (Radscore) is calculated. Finally, the receiver operating characteristic curve (ROC) is analyzed to calculate the AUC, accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of TNBC.

Results

A significant difference in the mammography manifestation between the triple-negative and the non-triple-negative groups (P < 0.001) is observed. The (POE + ACC)-NDA method showed the highest accuracy of 88.39%. The Radscore of triple-negative and non-triple-negative groups in the training set includes − 0.678 (− 1.292, 0.088) and − 2.536 (− 3.496, − 1.324), respectively, with a statistically significant difference (Z = − 6.314, P < 0.001). In contrast, the Radscore in the validation set includes − 0.750 (− 1.332, − 0.054) and − 2.223 (− 2.963, − 1.256), with a statistically significant difference (Z = − 4.669, P < 0.001). In the training set, the AUC, accuracy, sensitivity, specificity, positive predictive value and negative predictive value of TNBC include 0.821 (95% confidence interval 0.752–0.890), 74.4%, 82.5%, 72.5%, 41.2%, and 94.6%, respectively. In the validation set, the AUC, accuracy, sensitivity, specificity, positive predictive value and negative predictive value of TNBC are of 0.809 (95% confidence interval 0.711–0.907), 80.6%, 72.0%, 80.7%, 55.5%, and 93.1%, respectively.

Conclusion

In summary, we firmly believe that this mammography-based radiomics signature could be useful in the preoperative prediction of TNBC due to its high value.
Computed tomography and magnetic resonance imaging findings in gouty arthritis involving large joints of the upper extremities
Authors: Yang Yuling , Guo Yongfei , Yu Shuiquan , Zou Bin
Published: September 2022

Background

We aimed to analyze the computed tomography (CT) and magnetic resonance imaging (MRI) findings of gouty arthritis primarily involving the large joints of the upper limbs, signal or density characteristics of the tophi, growth patterns, involvement of the adjacent joints, and differentiation from other lesions occurring in this area and to discuss the causes of misdiagnosis.

Methods

CT and MRI data were collected from 14 patients with gouty arthritis, primarily involving the shoulder and elbow joints, and their imaging features were analyzed.

Results

All the patiens were ranged from 28-85 years old, and the tophi deposition can be observed on either CT or MRI.The tophi deposition apperas as slightly higher density nodules or masses on CT images,or nodules or masses on MRI with isosignal/hypointensity on T1WI and hyperintensity on T2WI. Five patients showed narrowing of the affected joint space, four had different degrees of bone erosion under the articular surface, eight developed joint effusion, and all showed surrounding soft tissue swelling. The tophi grew around the joint, with anterolateral and posterolateral tophi predominantly in the shoulder joint and dorsal tophi predominantly in the elbow joint on the MRI, with compression and edema of the surrounding soft tissues.

Conclusions

Gouty arthritis occurs in the large joints of the upper limbs and is characterized by fluid accumulation in the joint capsule and the formation of tophi. These tophi are usually large, with subcutaneous bone resorption and erosion, with or without cartilage destruction. However, extensive edema appeared in the soft tissue around the tophi, but the edema only produced pressure without any obvious signs of soft tissue infiltration, which may be distinguished from the joint tumor. In addition, the gout incidence rate is increased in young patients. Therefore, when the patient has a large joint mass, it is important to confirm whether there is a history of gout.
Effectiveness of early essential newborn care on breastfeeding and maternal outcomes: a nonrandomized controlled study
Authors: Huang Chuanya , Hu Lei , Wang Yonghong , Luo Biru
Published: September 2022

Background

Breastfeeding and maternal health play crucial roles in improving newborn health, which is closely related to the development of families and society. Early essential newborn care, which emphasizes early exclusive breastfeeding and skin-to-skin contact, is recommended by the World Health Organization. This study aimed to explore the association of early essential newborn care with breastfeeding and maternal outcomes.

Methods

A nonrandomized controlled study was carried out from May 2020 to January 2021 in a tertiary hospital in Chengdu city, China. Pregnant women were recruited from the maternity ward before they gave birth. Early essential newborn care was performed for 91 mother-newborn pairs after birth in the intervention group, while routine birth care was performed for 91 mother-newborn pairs in the control group. Data on breastfeeding and maternal outcomes were collected pre-test and post-test and were recorded by trained data collectors and retrieved from hospital case record files.

Results

Compared with the control group, the intervention group had a higher incidence of early breastfeeding initiation, an earlier initiation and longer duration for the first breastfeeding, a higher incidence of successful first breastfeeding, more exclusive breastfeeding at hospital discharge, higher maternal breastfeeding self-efficacy, a shorter duration of the third stage of labour, lower postpartum blood loss, and lower scores of maternal pain and anxiety postpartum; the differences were statistically significant (p < 0.05).

Conclusion

The implementation of high-quality early essential newborn care can help mothers initiate early breastfeeding, improve exclusive breastfeeding rates at hospital discharge, enhance breastfeeding self-efficacy, promote the woman’s recovery from labour, and reduce maternal anxiety and pain in the postpartum period. High-quality early essential newborn care is recommended to policymakers and medical professionals to improve breastfeeding and maternal outcomes.

Trial registration

Chinese Clinical Trial Registry, Retrospective Registration (27/7/2021), registration number: ChiCTR2100049231.
NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways
Authors: Feng Wen-Ming , Gong Hui , Wang Yong-Chun , Wang Yao , Xue Tao , Zhang Ting , Cui Ge
Published: September 2022

Objective

To investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer. 

Methods

Immunohistochemical staining was used to detect in situ expression of NudCD1 in 100 colorectal cancer tissue samples. A chi-square test was used to analyse the correlation between the NudCD1 protein expression level of the cancer tissues and clinicopathological features. The Kaplan–Meier survival analysis was used to assess the correlation between the NudCD1 mRNA expression and the three-year survival of patients with colorectal cancer. The impact of NudCD1 on the development of colorectal cancer and the underlying molecular mechanisms were assessed by flow cytometry cell cycle and apoptosis assays after lentiviral overexpression of NudCD1 in two colorectal cancer cell lines. Quantitative real-time PCR was used to assess mRNA expression of the cellular spindle assembly checkpoint genes BUB1, BUBR1, MAD1, CDC20 and MPS1, as well as the downstream genes LIS1, DYNC1H1, and DYNLL1 in the NudC/LIS1/dynein pathway.

Results

Compared with normal intestinal tissue (8.00% with high expression), the expression of NudCD1 protein in colorectal cancer tissue was significantly higher (58.00% with high expression, P < 0.01). In addition, expression of NudCD1 significantly correlated with the degree of tumour differentiation and the TNM staging (P < 0.01), as well as the depth of invasion of the primary tumour and lymph node metastasis (P < 0.05). However, there was no correlation with gender, age, tumour site, gross type, tumour size or distant metastasis. The Kaplan–Meier survival analysis showed that patients with high NudCD1 expression in colorectal cancer tissues had a significantly shorter survival time than those with low expression of NudCD1 (P < 0.01). Compared with the transfection of the empty vector, colon cancer HT-29 cells with overexpressed NudCD1 had significantly increased mRNA levels of BUBR1, MPS1 and LIS1. The DNA synthesis phase (S phase) was significantly shorter in cells overexpressing NudCD1 than in the control group (43.83% ± 1.57%, P < 0.05), while there was no difference in apoptosis in the two groups.

Conclusion

NudCD1 can serve as a valuable prognostic marker for colorectal cancer. It may be involved in the regulation of spindle-assembly checkpoint-gene expression and the LIS1 pathway of colorectal cancer cells.
Transition to endemic: acceptance of additional COVID-19 vaccine doses among Canadian adults in a national cross-sectional survey
Authors: Reifferscheid Laura , Lee Janet Sau Wun , MacDonald Noni E. , Sadarangani Manish , Assi Ali , Lemaire-Paquette Samuel , MacDonald Shannon E.
Published: September 2022

Background

Additional doses of COVID-19 vaccine have been proposed as solutions to waning immunity and decreased effectiveness of primary doses against infection with new SARS-CoV-2 variants. However, the effectiveness of additional vaccine doses relies on widespread population acceptance. We aimed to assess the acceptance of additional COVID-19 vaccine doses (third and annual doses) among Canadian adults and determine associated factors.

Methods

We conducted a national, cross-sectional online survey among Canadian adults from October 14 to November 12, 2021. Weighted multinomial logistic regression analyses were used to identify sociodemographic and health-related factors associated with third and annual dose acceptance and indecision, compared to refusal. We also assessed influences on vaccine decision-making, and preferences for future vaccine delivery.

Results

Of 6010 respondents, 70% reported they would accept a third dose, while 15.2% were undecided. For annual doses, 64% reported acceptance, while 17.5% were undecided. Factors associated with third dose acceptance and indecision were similar to those associated with annual dose acceptance and indecision. Previous COVID-19 vaccine receipt, no history of COVID-19 disease, intention to receive an influenza vaccine, and increasing age were strongly associated with both acceptance and indecision. Chronic illness was associated with higher odds of acceptance, while self-reported disability was associated with higher odds of being undecided. Higher education attainment and higher income were associated with higher odds of accepting additional doses. Minority first language was associated with being undecided about additional doses, while visible minority identity was associated with being undecided about a third dose and refusing an annual dose. All respondents reported government recommendations were an important influence on their decision-making and identified pharmacy-based delivery and drop-in appointments as desirable. Co-administration of COVID-19 and influenza vaccines was viewed positively by 75.5% of the dose 3 acceptance group, 12.3% of the undecided group, and 8.4% of the refusal group.

Conclusions

To increase acceptance, targeted interventions among visible minority and minority language populations, and those with a disability, are required. Offering vaccination at pharmacies and through drop-in appointments are important to facilitate uptake, while offering COVID-19/influenza vaccine co-administration may have little benefit among those undecided about additional doses.
Enzalutamide in patients with non-metastatic castration-resistant prostate cancer after combined androgen blockade for recurrence following radical treatment in Japan (Japanese research for patients with non-metastatic castration-resistant prostate cancer-enzalutamide: JCASTRE-zero)—a prospective single-arm interventional study
Authors: Sugimoto Mikio , Kato Takuma , Tohi Yoichiro , Shimizu Yosuke , Matsumoto Ryuji , Inoue Takahiro , Takezawa Yutaka , Masui Kimihiko , Sasaki Hiroshi , Hirama Hiromi , Saito Shiro , Egawa Shin , Kamoto Toshiyuki , Teramukai Satoshi , Kojima Shinsuke , Kikuchi Takashi , Kakehi Yoshiyuki
Published: September 2022

Background

The effect of enzalutamide in patients with non-metastatic castration-resistant prostate cancer after combined androgen blockade, which represents a patient profile similar to real-world clinical practice in Japan, remains unknown. Therefore, we investigate the efficacy and safety of enzalutamide after combined androgen blockade for recurrence following radical treatment in Japanese patients with non-metastatic castration-resistant prostate cancer.

Methods

We analyzed 66 patients with non-metastatic castration-resistant prostate cancer after combined androgen blockade for recurrence following radical prostatectomy or radiation therapy who were prospectively enrolled from October 2015 to March 2018. They received enzalutamide 160 mg orally once daily until the protocol treatment discontinuation criteria were met. The primary endpoint was prostate-specific antigen-progression-free survival, defined as the time from enrollment to prostate-specific antigen-based progression or death from any cause. The secondary endpoints included overall survival, progression-free survival, metastasis-free survival, time to prostate-specific antigen progression, prostate-specific antigen response rate, chemotherapy-free survival, and safety assessment.

Results

The median observation period was 27.3 months. The median prostate-specific antigen-progression-free survival was 35.0 months (95% confidence interval, 17.5 to not reached). The median overall survival, median progression-free survival, median metastasis-free survival, and chemotherapy-free survival were not reached, with the corresponding 2-year rates being 91.6%, 67.1%, 72.4%, and 85.8%, respectively. The 50% prostate-specific antigen response rate was 88.9%, with the median time being 2.8 months. In total, 42.2% of the patients experienced adverse events, with malaise being the most common.

Conclusions

Enzalutamide effectively manages non-metastatic castration-resistant prostate cancer after combined androgen blockade for recurrence following radical treatment.

Trialregistration: UMIN000018964, CRB6180007.
Outcomes of ureteroscopy and internal ureteral stent for pregnancy with urolithiasis: a systematic review and meta-analysis
Authors: Jin Xingwei , Liu Boke , Xiong Yunqi , Wang Yuanchun , Tu Weichao , Shao Yuan , Zhang Lin , Wang Dawei
Published: September 2022

Objectives

To investigate the outcomes of internal ureteral stents in comparison with ureteroscopy (URS) for pregnant women with urolithiasis.

Data sources

Relevant studies published from January 1980 to June 2022 were identified through systematic literature searches of MEDLINE, EMBASE, Web of Science and the Cochrane Library.

Methods of study selection

A total of 499 studies were initially identified. We included pregnant women in any stages of gestation who underwent double-J (D-J) stent insertion only or ureteroscopy for the treatment of urolithiasis; for a study to be included, the number of participants needed to exceed 10. This systematic review was registered on the PROSPERO website (Reference: CRD42020195607).

Results

A total of 25 studies were identified with 131 cases undergoing serial stenting and 789 cases undergoing URS. The pooled operative success rate was 97% for D-J stent insertion and 99% for URS. Only a few patients passed stones spontaneously after serial D-J stenting. The pooled stone free rate (SFR) in URS operations was about 91%. For internal ureteral stent therapy, the rate of normal fertility outcomes was 99%, although the pooled incidence of complications was approximately 45%. For group receiving URS treatment, the rate of normal fertility outcome was 99% and the pooled incidence of complications was approximately 1%. However, the pooled rate of premature birth and abortion were the similar between the two groups (< 1%); the rate of serious complications was also similar between the two groups.

Conclusions

Although internal ureteral stents may cause more minor complications, both ureteroscopy and internal ureteral stents showed had low rates of adverse effects on fertility outcomes when used to treat pregnant women with symptomatic urolithiasis. Evidence suggests that URS may have a greater advantage for pregnant patients with urinary stones when conditions permit. Since, it has been proven to be safe and effective, internal ureteral stents could be considered in emergency or other special situations.