bluuebunny/crossref_metadata_2025 huggingface dataset:
A New Automatic Monitoring Network of Surface Waters in Greece: Preliminary Data Quality Checks and Visualization
Authors: Panagopoulos Yiannis , Konstantinidou Anna , Lazogiannis Konstantinos , Papadopoulos Anastasios , Dimitriou Elias
Published: February 2021

The monitoring of surface waters is of fundamental importance for their preservation under good quantitative and qualitative conditions, as it can facilitate the understanding of the actual status of water and indicate suitable management actions. Taking advantage of the experience gained from the coordination of the national water monitoring program in Greece and the available funding from two ongoing infrastructure projects, the Institute of Inland Waters of the Hellenic Centre for Marine Research has developed the first homogeneous real-time network of automatic water monitoring across many Greek rivers. In this paper, its installation and maintenance procedures are presented with emphasis on the data quality checks, based on values range and variability tests, before their online publication and dissemination to end-users. Preliminary analyses revealed that the water pH and dissolved oxygen (DO) sensors and produced data need increased maintenance and quality checks respectively, compared to the more reliably recorded water stage, temperature (T) and electrical conductivity (EC). Moreover, the data dissemination platform and selected data visualization options are demonstrated and the need for both this platform and the monitoring network to be maintained and potentially expanded after the termination of the funding projects is highlighted.
Impact of Lifestyle Intervention Programs for Children and Adolescents with Overweight or Obesity on Body Weight and Selected Cardiometabolic Factors—A Systematic Review
Authors: Bondyra-Wiśniewska Beata , Myszkowska-Ryciak Joanna , Harton Anna
Published: February 2021

Excessive body mass is a health problem among children and adolescents that contributes to the occurrence of lipid disorders and abnormal blood pressure. Effective treatment of excessive body mass in children is essential for the health of population in the future. The aim of the study was to identify universal components of lifestyle interventions in children and adolescents with overweight or obesity leading to weight loss and improvement of selected cardiometabolic parameters. The review included studies from the PubMed and Google Scholar databases published in 2010–2019, which were analyzed for eligibility criteria including age of the participants, BMI defined as overweight or obese, nutritional intervention and the assessment of BMI and/or BMI z-score and at least one lipid profile parameter. Eighteen studies were included in the review, presenting the results of 23 intervention programs in which a total of 1587 children and adolescents participated. All interventions, except one, were multi-component. Data analysis suggests a relationship between a decrease in BMI and/or BMI z-score with diet and physical activity, the involvement of a dietician/nutrition specialist and physician in the treatment team and a longer duration of intervention. Moreover, it seems that a decrease in BMI is mostly associated with decreases in total cholesterol, triglycerides, low density lipoprotein cholesterol and blood pressure. No change in BMI and/or BMI z-score is associated with no change in blood pressure. Our data can be used by public health authorities to design effective weight loss programs for children and adolescents.
Metabolic Syndromes as Important Comorbidities in Patients of Inherited Retinal Degenerations: Experiences from the Nationwide Health Database and a Large Hospital-Based Cohort
Authors: Chiou Guann-Jye , Huang Ding-Siang , Hu Fung-Rong , Yang Chung-May , Yang Chang-Hao , Huang Ching-Wen , Lin Jou-Wei , Lin Chao-Wen , Ho Tzyy-Chang , Hsieh Yi-Ting , Lai Tso-Ting , Chen Ho-Min , Chen Pei-Lung , Hsiao Chuhsing Kate , Chen Ta-Ching
Published: February 2021

This study aimed to evaluate the medical and socioeconomic impacts of IRDs using the nationwide health database and a large hospital-based cohort. This retrospective cross-sectional cohort study used data from the nationwide National Health Insurance Research Database (NHIRD). All patients with IRD from January 2012 to December 2016 were selected from the NHIRD and matched with the general population at a ratio of 1:4. All variables, including comorbidities, medications, service utilization, and medical costs, within 1 year from the date of the IRD diagnosis, were analyzed. Disability data were retrieved from the Taiwan Inherited retinal degeneration Project (TIP), a medical center-based database. A total of 4447 and 17,788 subjects from the nationwide database were included in the IRD and control groups, respectively. The Charlson comorbidity index score was higher in the IRD group (0.74:0.52, p < 0.001). Yearly visits to the ophthalmology clinic were more frequent in the IRD group (6.80:1.06, p < 0.001), particularly to tertiary medical centers (p < 0.001). The IRD group showed greater odds ratios (OR) for metabolic syndrome-related comorbidities, including hypertension (OR = 1.18, 95% confidence interval (CI) 1.10 to 1.26) and diabetes (OR = 1.32, 95% CI 1.21 to 1.45), and double the average yearly medical cost (2104.3 vs. 1084.6 USD, p < 0.001) and ten times the yearly ophthalmology cost (369.1 vs. 36.1 USD, p < 0.001). The average disability level was 54.17% for all subjects. This study revealed the large medical and socioeconomic impacts of IRD on not only patients with IRD, but also their family members and the whole society.
Assessment of the Construction of a Climate Resilient City: An Empirical Study Based on the Difference in Differences Model
Authors: Liang Zifeng
Published: February 2021

Facing climate risks has become a common problem for mankind and a topic of great importance for the Chinese government. To thoroughly implement the overall requirements for the construction of an ecological civilization and effectively improve the capacity of cities to adapt to climate change, China launched the pilot construction of “Climate Resilient Cities” in 2017. In this paper, 16 prefecture level cities in Anhui Province of China were selected as the research objects, and the multi-level grey system evaluation method was used to measure the climate resilience of these regions. We used the difference in differences method to evaluate the effect of the pilot policy of “Climate Resilient Cities.” The pilot policies of the “Climate Resilient Cities” showed a significant contribution to the regional climate resilience, and, after isolating the impact of other factors on the regional climate resilience, the pilot policies of the “Climate Resilient Cities” increased the climate resilience of the pilot cities by four percentage points. The pilot policies of the “Climate Resilient Cities” had a significant contribution to the urban infrastructure development and ecological space optimization, as well as non-significant impacts to the urban water security, emergency management capacity-building, and science and technology innovation initiatives.
Structural Model of the Healthcare Information Security Behavior of Nurses Applying Protection Motivation Theory
Authors: Lee EunWon , Seomun GyeongAe
Published: February 2021

Background: Healthcare information includes sensitive data and, as such, must be secure; however, the risk of healthcare information leakage is increasing. Nurses manage healthcare information in hospitals; however, previous studies have either been conducted on medical workers from various other occupations or have not synthesized various factors. The purpose of this study was to create and prove a model of nurses’ healthcare information security (HIS). The hypothetical model used in this study was constructed on the basis of the protection motivation theory (PMT) proposed by Rogers. Methods: A total of 252 questionnaires scored using a five-point Likert scale were analyzed, incorporating data from nurses who had been working for more than one month in general hospitals with more than 300 beds in South Korea. The survey was conducted over a total of 30 days, from 1 to 30 September 2019. Results: The results showed that coping appraisal significantly influence HIS intentions (estimate = −1.477, p < 0.01), whereas HIS intentions significantly influence HIS behavior (estimate = 0.515, p < 0.001). A moderating effect on the association between coping appraisal and HIS intentions was found in the group of nurses who had been working for <5 years (estimate = −1.820, p < 0.05). Moreover, a moderating effect on the association between HIS intentions and HIS behavior was found in the group of nurses who had been working for <5 years (estimate = 0.600, p < 0.001). Conclusion: The results of this study can be used to develop a management plan to strengthen nurses’ HIS behavior and can be used by nursing managers as a basis for developing education programs.
Association of Health Literacy with the Implementation of Exercise during the Declaration of COVID-19 State of Emergency among Japanese Community-Dwelling Old-Old Adults
Authors: Shiratsuchi Daijo , Makizako Hyuma , Nakai Yuki , Taniguchi Yoshiaki , Akanuma Tomomi , Yokoyama Kaori , Matsuzaki-Kihara Yuriko , Yoshida Hiroto
Published: February 2021

Health literacy is important for promoting and maintaining good health in old-old adults. It may influence the implementation of exercise in the coronavirus disease epidemic. The present cross-sectional study investigated the association of each dimension of health literacy with the implementation of exercise during the declaration of a state of emergency due to coronavirus disease in community-dwelling old-old adults. We collected data from 483 community-dwelling old-old adults (52.8% women) aged between 77 and 99 years who participated in a mail survey. Participants were divided into exercise or nonexercise groups based on the implementation of exercise during the declaration of a state of emergency. Health literacy was assessed using a 14-item health literacy scale. There were 327 (67.7%) participants in the exercise group and 156 (32.3%) in the nonexercise group. A significantly higher score of health literacy was observed in the exercise group than in the nonexercise group (communicative health literacy score = 14.0 ± 3.6 vs. 12.7 ± 3.8, p = 0.001). In a multivariate logistic regression model adjusted for potential confounders, high communicative health literacy scores were significantly associated with the implementation of exercise during the declaration of a state of emergency (odds ratio = 1.88, 95% confidence interval = 1.20–2.93). Approximately two-thirds of community-dwelling old-old adults implement exercise during the declaration of a state of emergency. High communicative health literacy was associated with the implementation of exercise during this period.
Cross-Country Differences in Stay-at-Home Behaviors during Peaks in the COVID-19 Pandemic in China and the United States: The Roles of Health Beliefs and Behavioral Intention
Authors: Hong Wei , Liu Ru-De , Ding Yi , Hwang Jacqueline , Wang Jia , Yang Yi
Published: February 2021

The novel coronavirus disease 2019 (COVID-19) rapidly escalated to a global pandemic. To control the rate of transmission, governments advocated that the public practice social distancing, which included staying at home. However, compliance with stay-at-home orders has varied between countries such as China and the United States, and little is known about the mechanisms underlying the national differences. Based on the health belief model, the theory of reasoned action, and the technology acceptance model, health beliefs and behavioral intention are suggested as possible explanations. A total of 498 Chinese and 292 American college students were recruited to complete an online survey. The structural equation modeling results showed that health beliefs (i.e., perceived susceptibility, severity, and barriers) and behavioral intention played multiple mediating roles in the association between nationality and actual stay-at-home behaviors. Notably, the effect via perceived barriers → behavioral intention was stronger than the effects via perceived susceptibility and severity → behavioral intention. That is, American participants perceived high levels of susceptibility whereas Chinese participants perceived high levels of severity, especially few barriers, which further led to increased behavioral intention and more frequent stay-at-home behaviors. These findings not only facilitate a comprehensive understanding of cross-country differences in compliance with stay-at-home orders during peaks in the COVID-19 pandemic but also lend support for mitigation of the current global crisis and future disease prevention and health promotion efforts.
Assessment of Selected Aspects of the Quality of Life of Children with Type 1 Diabetes Mellitus in Poland
Authors: Grudziąż-Sękowska Justyna , Zamarlik Monika , Sękowski Kuba
Published: February 2021

Type 1 diabetes mellitus (T1D) is, next to obesity and asthma, the most common chronic disease in children in Poland. T1D is not only a medical challenge, but it also affects all areas of a sick child’s life and family functionality. New forms of therapy facilitate the daily management of the disease, but their availability is limited and partly dependent on socioeconomic status. This study aimed to assess the incidence and interrelationships between the child’s health condition and the applied therapy model, and selected aspects of the child’s family functionality and access to health and care services. The survey involved 206 child and youth caregivers with T1D who are members of Facebook support groups. The analysis of the obtained results revealed the existence of links between family income level and the type of insulin therapy applied. Children from families with a better financial situation (subjective and objective) were more likely to have additional medical consultations and make more frequent control visits. In families with a higher level of income, the T1D-induced restriction of child activity was less frequent. Living outside of urban centers was associated with a reduced availability of care or educational facilities adapted to take care of a child with T1D. No statistically significant correlations were observed between demographic and economic factors and the child’s health status expressed by the occurrence of complications. The incidence of the latter, however, affected the child’s family situation.
A Review on Human–AI Interaction in Machine Learning and Insights for Medical Applications
Authors: Maadi Mansoureh , Akbarzadeh Khorshidi Hadi , Aickelin Uwe
Published: February 2021

Objective: To provide a human–Artificial Intelligence (AI) interaction review for Machine Learning (ML) applications to inform how to best combine both human domain expertise and computational power of ML methods. The review focuses on the medical field, as the medical ML application literature highlights a special necessity of medical experts collaborating with ML approaches. Methods: A scoping literature review is performed on Scopus and Google Scholar using the terms “human in the loop”, “human in the loop machine learning”, and “interactive machine learning”. Peer-reviewed papers published from 2015 to 2020 are included in our review. Results: We design four questions to investigate and describe human–AI interaction in ML applications. These questions are “Why should humans be in the loop?”, “Where does human–AI interaction occur in the ML processes?”, “Who are the humans in the loop?”, and “How do humans interact with ML in Human-In-the-Loop ML (HILML)?”. To answer the first question, we describe three main reasons regarding the importance of human involvement in ML applications. To address the second question, human–AI interaction is investigated in three main algorithmic stages: 1. data producing and pre-processing; 2. ML modelling; and 3. ML evaluation and refinement. The importance of the expertise level of the humans in human–AI interaction is described to answer the third question. The number of human interactions in HILML is grouped into three categories to address the fourth question. We conclude the paper by offering a discussion on open opportunities for future research in HILML.
Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells
Authors: Hossain Kaniz Fatima Binte , Akter Mahmuda , Rahman Md. Mostafizur , Sikder Md. Tajuddin , Rahaman Md. Shiblur , Yamasaki Shojiro , Kimura Goh , Tomihara Tomomi , Kurasaki Masaaki , Saito Takeshi
Published: February 2021

α-Lipoic acid (ALA) and its reduced form dihydrolipoic acid (DHLA) are endogenous dithiol compounds with significant antioxidant properties, both of which have the potential to detoxify cells. In this study, ALA (250 μM) and DHLA (50 μM) were applied to reduce metal (As, Cd, and Pb)-induced toxicity in PC12 and Caco-2 cells as simultaneous exposure. Both significantly decreased Cd (5 μM)-, As (5 μM)-, and Pb (5 μM)-induced cell death. Subsequently, both ALA and DHLA restored cell membrane integrity and intracellular glutathione (GSH) levels, which were affected by metal-induced toxicity. In addition, DHLA protected PC12 cells from metal-induced DNA damage upon co-exposure to metals. Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure. In contrast, in Caco-2 cells, upon co-exposure to metals and ALA, Nrf2 was upregulated and cleaved PARP-1 (poly (ADP-ribose) polymerase-1) was downregulated. These findings suggest that ALA and DHLA can counterbalance the toxic effects of metals. The protection of ALA or DHLA against metal toxicity may be largely due to an enhancement of antioxidant defense along with reduced glutathione level, which ultimately reduces the cellular oxidative stress.
Evaluation of the Use of Shared Decision Making in Breast Cancer: International Survey
Authors: Maes-Carballo Marta , Martín-Díaz Manuel , Mignini Luciano , Khan Khalid Saeed , Trigueros Rubén , Bueno-Cavanillas Aurora
Published: February 2021

Objectives: To assess shared decision-making (SDM) knowledge, attitude and application among health professionals involved in breast cancer (BC) treatment. Materials and Methods: A cross-sectional study based on an online questionnaire, sent by several professional societies to health professionals involved in BC management. There were 26 questions which combined demographic and professional data with some items measured on a Likert-type scale. Results: The participation (459/541; 84.84%) and completion (443/459; 96.51%) rates were high. Participants strongly agreed or agreed in 69.57% (16/23) of their responses. The majority stated that they knew of SDM (mean 4.43 (4.36–4.55)) and were in favour of its implementation (mean 4.58 (4.51–4.64)). They highlighted that SDM practice was not adequate due to lack of resources (3.46 (3.37–3.55)) and agreed on policies that improved its implementation (3.96 (3.88–4.04)). The main advantage of SDM for participants was patient satisfaction (38%), and the main disadvantage was the patients’ paucity of knowledge to understand their disease (24%). The main obstacle indicated was the lack of time and resources (40%). Conclusions: New policies must be designed for adequate training of professionals in integrating SDM in clinical practice, preparing them to use SDM with adequate resources and time provided.
Thirty Years of Human Rights Study in the Web of Science Database (1990–2020)
Authors: Severo Priscilla Paola , Furstenau Leonardo B. , Sott Michele Kremer , Cossul Danielli , Bender Mariluza Sott , Bragazzi Nicola Luigi
Published: February 2021

The study of human rights (HR) is vital in order to enhance the development of human beings, but this field of study still needs to be better depicted and understood because violations of its core principles still frequently occur worldwide. In this study, our goal was to perform a bibliometric performance and network analysis (BPNA) to investigate the strategic themes, thematic evolution structure, and trends of HR found in the Web of Science (WoS) database from 1990 to June 2020. To do this, we included 25,542 articles in the SciMAT software for bibliometric analysis. The strategic diagram produced shows 23 themes, 12 of which are motor themes, the most important of which are discussed in this article. The thematic evolution structure presented the 21 most relevant themes of the 2011–2020 period. Our findings show that HR research is directly related to health issues, such as mental health, HIV, and reproductive health. We believe that the presented results and HR panorama presented have the potential to be used as a basis on which researchers in future works may enhance their decision making related to this field of study.
Injury and Illness in World Taekwondo Junior Athletes: An Epidemiological Study
Authors: Jeong Hee Seong , Ha Sunghe , Jeong Dae Hyoun , O’Sullivan David Michael , Lee Sae Yong
Published: February 2021

Taekwondo has been reported to be one of the most injurious sports in the summer Olympics, however, there is a dearth of data about injury profiles for junior athletes. Therefore, we aimed to identify the incidence and profiles of the injuries and illnesses that occurred during the 2018 World Taekwondo Junior Championships and recorded using an online system. Among the 889 athletes, 67 injuries and four illnesses were reported, corresponding to an overall clinical incidence of 7.5 injuries (95% confidence interval [CI]: 5.7–9.3) and 0.5 illnesses (0.1–0.9) per 100 athletes. The most frequent injuries were lower extremity injuries (n = 33, 3.71% of all athletes), mostly in the foot/toe (n = 11, 1.2% of athletes), followed by head and trunk injuries, mostly in the face (n = 14, 1.6% of athletes), and upper extremity injuries, mostly in the fingers (n = 6, 0.7% of athlete). Contusions (n = 37, 4.2% of athlete) were the most frequent injury type, followed by ligament ruptures/sprains and laceration. The most common injury mechanism was contact during an opponent attack (n = 51, 5.7% of athlete). Three mild concussions none resulted in time loss (none required hospital transfer or had prolonged recovery). The respiratory system was the most affected by illness, with pain and fever as symptoms. Environmental factors were the most common cause of illness. This study shows that 7.5 per 100 athletes (38.5/1000 athlete-exposures and 6.9/1000 min-exposures) had new or recurrent injuries, whereas 0.5 per 100 athletes experienced illness. In conclusion, the data shows male athletes reported more injuries than females and the most common cause of injury was due to contact between athletes. Contusions, ligament rupture/sprains, laceration and fractures to the lower extremities, head, and trunk were the most common injury. Knowing these injury profiles of junior taekwondo athletes can help taekwondo stakeholders, especially medical staff to prepare accordingly to ensure the safety of the athletes.
Burnout and Cognitive Performance
Authors: Koutsimani Panagiota , Montgomery Anthony , Masoura Elvira , Panagopoulou Efharis
Published: February 2021

The aim of this study was to investigate the relationship between burnout and cognitive functioning. The associations of depression, anxiety and family support with burnout and cognitive functioning were also examined both independently and as potential moderators of the burnout–cognitive functioning relationship. Seven different cognitive tasks were administered to employees of the general working population and five cognitive domains were assessed; i.e., executive functions, working memory, memory (episodic, visuospatial, prospective), attention/speed of processing and visuospatial abilities. Burnout, depression, anxiety and family support were assessed with the Maslach Burnout Inventory-General Survey, the Hospital Anxiety and Depression Scale and the Family Support Scale respectively. In congruence with the first and fourth (partially) Hypotheses, burnout and perceived family support are significantly associated with some aspects of cognitive functioning. Moreover, in line with the third Hypothesis, perceived family support is inversely related to burnout. However, in contrast to the second and fourth Hypotheses, depression, anxiety and perceived family support do not moderate the burnout–cognitive functioning relationship. Additional results reveal positive associations between burnout depression and anxiety. Overall findings suggest that cognitive deficits, depression and anxiety appear to be common in burnout while they underpin the role of perceived family support in both mental health and cognitive functioning. Implications for practice are discussed.
Social Determinants of Diabetes-Related Preventable Hospitalization in Taiwan: A Spatial Analysis
Authors: Li Chung-Yi , Chuang Yung-Chung , Chen Pei-Chun , Chen Michael S. , Lee Miaw-Chwen , Ku Li-Jung Elizabeth , Lee Chiachi Bonnie
Published: February 2021

Diabetes-Related Preventable Hospitalization (DRPH) has been identified as an important indicator of efficiency and quality of the health system and can be modified by social determinants. However, the spatial disparities, clustering, and relationships between DRPH and social determinants have rarely been investigated. Accordingly, this study examined the association of DRPH with area deprivation, densities of certificated diabetes health-promoting clinics (DHPC) and hospitals (DHPH), and the presence of elderly social services (ESS) using both statistical and spatial analyses. Data were obtained from the 2010–2016 National Health Insurance Research Database (NHIRD) and government open data. Township-level ordinary least squares (OSL) and geographically weighted regression (GWR) were conducted. DRPH rates were found to be negatively associated with densities of DHPC (β = −66.36, p = 0.029; 40.3% of all townships) and ESS (β = −1.85, p = 0.027; 28.4% of all townships) but positively associated with area deprivation (β = 2.96, p = 0.002; 25.6% of all townships) in both OLS and GWR models. Significant relationships were found in varying areas in the GWR model. DRPH rates are high in townships of Taiwan that have lower DHPC densities, lower ESS densities, and greater socioeconomic deprivation. Spatial analysis could identify areas of concern for potential intervention.
CustodyBlock: A Distributed Chain of Custody Evidence Framework
Authors: Alruwaili Fahad F.
Published: February 2021

With the increasing number of cybercrimes, the digital forensics team has no choice but to implement more robust and resilient evidence-handling mechanisms. The capturing of digital evidence, which is a tangible and probative piece of information that can be presented in court and used in trial, is very challenging due to its volatility and improper handling procedures. When computer systems get compromised, digital forensics comes into play to analyze, discover, extract, and preserve all relevant evidence. Therefore, it is imperative to maintain efficient evidence management to guarantee the credibility and admissibility of digital evidence in a court of law. A critical component of this process is to utilize an adequate chain of custody (CoC) approach to preserve the evidence in its original state from compromise and/or contamination. In this paper, a practical and secure CustodyBlock (CB) model using private blockchain protocol and smart contracts to support the control, transfer, analysis, and preservation monitoring is proposed. The smart contracts in CB are utilized to enhance the model automation process for better and more secure evidence preservation and handling. A further research direction in terms of implementing blockchain-based evidence management ecosystems, and the implications on other different areas, are discussed.
The Eco-Bio-Social Factors That Modulate Aedes aegypti Abundance in South Texas Border Communities
Authors: Juarez Jose , Garcia-Luna Selene , Medeiros Matthew , Dickinson Katherine , Borucki Monica , Frank Matthias , Badillo-Vargas Ismael , Chaves Luis , Hamer Gabriel
Published: February 2021

Aedes aegypti control requires dedicated resources that are usually scarce, limiting the reach and sustainability of vector control programs. This generates a need to focus on areas at risk of disease transmission and also understand the factors that might modulate local mosquito abundance. We evaluated the eco-bio-social factors that modulate indoor and outdoor relative abundance of female Ae. aegypti in communities of South Texas. We conducted housing quality and Knowledge Attitudes and Practices surveys in households that were part of a weekly mosquito surveillance program in November of 2017 and 2018. Our results showed widespread knowledge of mosquitoes and Zika virus by our participants. However, less than 35% considered them as serious problems in this region. The presence of window-mounted air conditioning units increased the risk of female mosquito relative abundance indoors. An increase in outdoor relative abundance was associated with larger properties and a higher number of children between 6 to 17 years of age. Interestingly, we observed that an increasing number of children <5 years of age modulated both indoor and outdoor relative abundance, with a 52% increase indoors and 30% decrease outdoors. The low perception of mosquito and disease risk highlights engagement needs for vector-borne disease prevention in this region. The identified risk factors can help guide public health officials in their efforts to reduce human and vector contact.
Toxicity of Insecticides and Miticides to Natural Enemies in Australian Grains: A Review
Authors: Overton Kathy , Hoffmann Ary A. , Reynolds Olivia L. , Umina Paul A.
Published: February 2021

Continued prophylactic chemical control to reduce pest populations in Australian grain farming systems has limited the effectiveness of biological control via natural enemies in crops within an integrated pest management (IPM) framework. While a variety of data is available to infer potential non-target effects of chemicals on arthropod natural enemies, much of it may be irrelevant or difficult to access. Here, we synthesise the literature relevant to Australian grain crops and highlight current knowledge gaps for potential future investment. A range of testing methodologies have been utilised, often deviating from standardised International Organization for Biological Control (IOBC) protocols. Consistent with findings from over 30 years ago, research has continued to occur predominantly at laboratory scales and on natural enemy families that are easily reared or commercially available. There is a paucity of data for many generalist predators, in particular for spiders, hoverflies, and rove and carabid beetles. Furthermore, very few studies have tested the effects of seed treatments on natural enemies, presenting a significant gap given the widespread global use of neonicotinoid seed treatments. There is a need to validate results obtained under laboratory conditions at industry-relevant scales and also prioritise testing on several key natural enemy species we have identified, which should assist with the adoption of IPM practices and decrease the reliance on broad-spectrum chemicals.
Predictors of Progression and Mortality in Patients with Prevalent Rheumatoid Arthritis and Interstitial Lung Disease: A Prospective Cohort Study
Authors: Mena-Vázquez Natalia , Rojas-Gimenez Marta , Romero-Barco Carmen María , Manrique-Arija Sara , Francisco Espildora , Aguilar-Hurtado María Carmen , Añón-Oñate Isabel , Pérez-Albaladejo Lorena , Ortega-Castro Rafaela , Godoy-Navarrete Francisco Javier , Ureña-Garnica Inmaculada , Velloso-Feijoo Maria Luisa , Redondo-Rodriguez Rocio , Jimenez-Núñez Francisco Gabriel , Panero Lamothe Blanca , Padin-Martín María Isabel , Fernández-Nebro Antonio
Published: February 2021

Objectives: To describe a prospective cohort of patients with rheumatoid arthritis associated with interstitial lung disease (RA-ILD) and identify risk factors associated with disease progression and mortality in this cohort. Patients and methods: We performed a multicenter, prospective, observational study of patients with RA-ILD receiving disease-modifying antirheumatic drugs (DMARDs) between 2015 and 2020. The patients were assessed using high-resolution computed tomography and pulmonary function tests at baseline and at 60 months. The main endpoint was “Progression to ILD at the end of follow-up” in terms of the following outcomes: (1) improvement (i.e., improvement in forced vital capacity (FVC) ≥10% or diffusing capacity of the lungs for carbon monoxide (DLCO) ≥15% and absence of radiological progression); (2) nonprogression (stabilization or improvement in FVC ≤10% or diffusing capacity of the lungs for carbon monoxide (DLCO) <15% and absence of radiological progression); (3) progression (worsening of FVC >10% or DLCO >15% and radiological progression); or (4) death. We recorded demographic and clinical characteristics, lung function, and the incidence of adverse events. A Cox regression analysis was performed to identify factors associated with the worsening of ILD. Results: After 60 months, lung disease had stabilized in 66 patients (56.9%), improved in 9 (7.8%), and worsened in 23 (19.8%). Eighteen patients (15.5%) died, with a mean survival of 71.8 (1.9) months after diagnosis of ILD. The Cox multivariate analysis revealed the independent predictors of worsening of RA-ILD to be usual interstitial pneumonia (hazard ratio (HR), 2.6 (95%CI, 1.0–6.7)), FVC <80% (HR, 3.8 (95%CI, 1.5–6.7)), anticitrullinated protein antibody titers (HR, 2.8 (95%CI, 1.1–6.8)), smoking (HR, 2.5 (95%CI, 1.1–6.2)), and treatment with abatacept, tocilizumab, or rituximab (HR, 0.4 (95%CI, 0.2–0.8)). During follow-up, 79 patients (68%) experienced an adverse event, mostly infection (61%). Infection was fatal in 10/18 patients (55.5%) during follow-up. Conclusions: Lung function is stable in most patients with RA-ILD receiving treatment with disease-modifying anti-rheumatic drugs (DMARDs), although one-third worsened or died. Identifying factors associated with worsening in RA-ILD is important for clinical management.
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort
Authors: Yazdani Mazyar , Fiskådal Jørgen , Chen Xiangjun , Utheim Øygunn A. , Ræder Sten , Vitelli Valeria , Utheim Tor P.
Published: February 2021

This study evaluated to what extent tear film break-up time (TFBUT) could discriminate pathological scores for other clinical tests and explore the associations between them. Dry eye patients (n = 2094) were examined for ocular surface disease index (OSDI), tear film osmolarity (Osm), TFBUT, blink interval, ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test, meibomian expressibility, meibomian quality, and meibomian gland dysfunction. The results were grouped into eight levels of break-up time (≤2, ≥3, ≤5, ≥6, ≤10, ≥11, ≤15, and ≥16) with or without sex stratification. Receiver-operating characteristic curve (ROC) analysis and Pearson’s correlation coefficients were used to study TFBUT’s discriminative power and the associations among the tests, respectively. Above and below each TFBUT’s cut-off, all of the parameters indicated significant difference between groups, except OSDI (cut-off 15 s) and Osm (cut-offs 5 s–15 s). At TFBUT cut-off of 2 s, sex difference could be detected for OSDI, Osm, and OSS. OPI presented the strongest discriminative power and association with TFBUT in sharp contrast to Osm, holding the poorest discriminative power with no significant correlation. The remaining parameters were within the poor to very poor categories, both with regard to discrimination and correlation. In conclusion, patients with lower TFBUT presented with more severe DED parameters at all four defined cut-off values.
Performance Overview of the Latest Video Coding Proposals: HEVC, JEM and VVC
Authors: Martínez-Rach Miguel O. , Migallón Héctor , López-Granado Otoniel , Galiano Vicente , Malumbres Manuel P.
Published: February 2021

The audiovisual entertainment industry has entered a race to find the video encoder offering the best Rate/Distortion (R/D) performance for high-quality high-definition video content. The challenge consists in providing a moderate to low computational/hardware complexity encoder able to run Ultra High-Definition (UHD) video formats of different flavours (360°, AR/VR, etc.) with state-of-the-art R/D performance results. It is necessary to evaluate not only R/D performance, a highly important feature, but also the complexity of future video encoders. New coding tools offering a small increase in R/D performance at the cost of greater complexity are being advanced with caution. We performed a detailed analysis of two evolutions of High Efficiency Video Coding (HEVC) video standards, Joint Exploration Model (JEM) and Versatile Video Coding (VVC), in terms of both R/D performance and complexity. The results show how VVC, which represents the new direction of future standards, has, for the time being, sacrificed R/D performance in order to significantly reduce overall coding/decoding complexity.
The Quantum Nature of Color Perception: Uncertainty Relations for Chromatic Opposition
Authors: Berthier Michel , Provenzi Edoardo
Published: February 2021

In this paper, we provide an overview on the foundation and first results of a very recent quantum theory of color perception, together with novel results about uncertainty relations for chromatic opposition. The major inspiration for this model is the 1974 remarkable work by H.L. Resnikoff, who had the idea to give up the analysis of the space of perceived colors through metameric classes of spectra in favor of the study of its algebraic properties. This strategy permitted to reveal the importance of hyperbolic geometry in colorimetry. Starting from these premises, we show how Resnikoff’s construction can be extended to a geometrically rich quantum framework, where the concepts of achromatic color, hue and saturation can be rigorously defined. Moreover, the analysis of pure and mixed quantum chromatic states leads to a deep understanding of chromatic opposition and its role in the encoding of visual signals. We complete our paper by proving the existence of uncertainty relations for the degree of chromatic opposition, thus providing a theoretical confirmation of the quantum nature of color perception.
Proof of Concept of a Breakwater-Integrated Hybrid Wave Energy Converter Using a Composite Modelling Approach
Authors: Koutrouveli Theofano I. , Di Lauro Enrico , das Neves Luciana , Calheiros-Cabral Tomás , Rosa-Santos Paulo , Taveira-Pinto Francisco
Published: February 2021

Despite the efforts of developers, investors and scientific community, the successful development of a competitive wave energy industry is proving elusive. One of the most important barriers against wave energy conversion is the efficiency of the devices compared with all the associated costs over the lifetime of an electricity generating plant, which translates into a very high Levelised Cost of Energy (LCoE) compared to that of other renewable energy technologies such as wind or solar photovoltaic. Furthermore, the industrial roll-out of Wave Energy Converter (WEC) devices is severely hampered by problems related to their reliability and operability, particularly in open waters and during harsh environmental sea conditions. WEC technologies in multi-purpose breakwaters—i.e., a structure that retains its primary function of providing sheltered conditions for port operations to develop and includes electricity production as an added co-benefit—appears to be a promising approach to improve cost-effectiveness in terms of energy production. This paper presents the proof of concept study of a novel hybrid-WEC (HWEC) that uses two well understood power generating technologies, air and water turbines, integrated in breakwaters, by means of a composite modelling approach. Preliminary results indicate: firstly, hybridisation is an adequate approach to harness the available energy most efficiently over a wide range of metocean conditions; secondly, the hydraulic performance of the breakwater improves; finally, no evident negative impacts in the overall structural stability specific to the integration were observed.
Improving Accuracy in Studying the Interactions of Seismic Waves with Bottom Sediments
Authors: Mitrofanov Georgy , Goreyavchev Nikita , Kushnarev Roman
Published: February 2021

The emerging tasks of determining the features of bottom sediments, including the evolution of the seabed, require a significant improvement in the quality of data and methods for their processing. Marine seismic data has traditionally been perceived to be of high quality compared to land data. However, high quality is always a relative characteristic and is determined by the problem being solved. In a detailed study of complex processes, the interaction of waves with bottom sediments, as well as the processes of seabed evolution over short time intervals (not millions of years), we need very high accuracy of observations. If we also need significant volumes of research covering large areas, then a significant revision of questions about the quality of observations and methods of processing is required to improve the quality of data. The article provides an example of data obtained during high-precision marine surveys and containing a wide frequency range from hundreds of hertz to kilohertz. It is shown that these data, visually having a very high quality, have variations in wavelets at all analyzed frequencies. The corresponding variations reach tens of percent. The use of the method of factor decomposition in the spectral domain made it possible to significantly improve the quality of the data, reducing the variability of wavelets by several times.
Virtual Level Analysis Applied to Wave Flume Experiments: The Case of Waves-Cubipod Homogeneous Low-Crested Structure Interaction
Authors: Escudero Mireille , Hernández-Fontes Jassiel V. , Hernández Irving D. , Mendoza Edgar
Published: February 2021

This paper presents the use of virtual level (VL) probes as an alternative image-based approach to investigate the interaction of waves with coastal structures in wave flume experiments. These probes are defined as regions of interest located at specific positions along the horizontal domain of the images, in which edge interfaces are detected and, thus, their vertical motions can be obtained. To demonstrate the use of the methodology, a critical condition of breaking waves interacting with a Cubipod homogeneous low-crested structure (HLCS) in a two-dimensional framework was selected. With the video recorded from the experiments, image calibration, processing, and analysis stages were implemented to analyze the performance of the HLCS in reducing wave elevations and to study the stability of the armor units. The present approach can be extended to a wide range of coastal structures applications where the interface detection between components of the scene is useful to observe the behavior of coastal structures, increasing effectiveness and alternatives to acquire precise data in 2D experimental tests.
Molecular Epidemiology of Aspergillus fumigatus in Chronic Pulmonary Aspergillosis Patients
Authors: van der Torre Mireille H. , Shen Hongwei , Rautemaa-Richardson Riina , Richardson Malcolm D. , Novak-Frazer Lilyann
Published: February 2021

Molecular fungal genotyping techniques developed and employed for epidemiological studies have understandably concentrated on establishing the genetic diversity of Aspergillus fumigatus in invasive aspergillosis due to its severity, the urgency for treatment, and the need to demonstrate possible sources. Some early studies suggested that these strains were phenotypically, if not genotypically, different from others. However, with improved discrimination and evaluations, incorporating environmental as well as clinical isolates from other Aspergillus conditions (e.g., chronic pulmonary aspergillosis and cystic fibrosis), this premise is no longer upheld. Moreover, with the onset of increased global triazole resistance, there has been a concerted effort to incorporate resistance profiling into genotyping studies and the realisation that the wider population of non-immunocompromised aspergillosis patients are at risk. This review summarises the developments in molecular genotyping studies that incorporate resistance profiling with attention to chronic pulmonary aspergillosis and an example of our UK experience.
The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi
Authors: Kuvarina Anastasia E. , Gavryushina Irina A. , Kulko Alexander B. , Ivanov Igor A. , Rogozhin Eugene A. , Georgieva Marina L. , Sadykova Vera S.
Published: February 2021

Novel antimicrobial peptides with antifungal and cytotoxic activity were derived from the alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this strain produced emericellipsin A (EmiA), which has strong antifungal and cytotoxic properties. Further analyses of the metabolites obtained under a special alkaline medium resulted in the isolation of four new homologous (Emi B–E). In this work, we report the complete primary structure and detailed biological activity for the newly synthesized nonribosomal antimicrobial peptides called emericellipsins B–E. The inhibitory activity of themajor compound, EmiA, against drug-resistant pathogenic fungi was similar to that of amphotericin B (AmpB). At the same time, EmiA had no hemolytic activity towards human erythrocytes. In addition, EmiA demonstrated low cytotoxic activity towards the normal HPF line, but possessed cancer selectivity to the K-562 and HCT-116 cell lines. Emericillipsins from the alkalophilic fungus Emericellopsis alkaline are promising treatment alternatives to licensed antifungal drugs for invasive mycosis therapy, especially for multidrug-resistant aspergillosis and cryptococcosis.
Comparison of Two Commercially Available qPCR Kits for the Detection of Candida auris
Authors: Sattler Janko , Noster Janina , Brunke Anne , Plum Georg , Wiegel Pia , Kurzai Oliver , Meis Jacques F. , Hamprecht Axel
Published: February 2021

Candida auris is an emerging pathogen with resistance to many commonly used antifungal agents. Infections with C. auris require rapid and reliable detection methods to initiate successful medical treatment and contain hospital outbreaks. Conventional identification methods are prone to errors and can lead to misidentifications. PCR-based assays, in turn, can provide reliable results with low turnaround times. However, only limited data are available on the performance of commercially available assays for C. auris detection. In the present study, the two commercially available PCR assays AurisID (OLM, Newcastle Upon Tyne, UK) and Fungiplex Candida Auris RUO Real-Time PCR (Bruker, Bremen, Germany) were challenged with 29 C. auris isolates from all five clades and eight other Candida species as controls. AurisID reliably detected C. auris with a limit of detection (LoD) of 1 genome copies/reaction. However, false positive results were obtained with high DNA amounts of the closely related species C. haemulonii, C. duobushaemulonii and C. pseudohaemulonii. The Fungiplex Candida Auris RUO Real-Time PCR kit detected C. auris with an LoD of 9 copies/reaction. No false positive results were obtained with this assay. In addition, C. auris could also be detected in human blood samples spiked with pure fungal cultures by both kits. In summary, both kits could detect C. auris-DNA at low DNA concentrations but differed slightly in their limits of detection and specificity.