bluuebunny/crossref_metadata_2025 huggingface dataset:
Face- and content validity of the University of the Free State In-Hand Manipulation Assessment Instrument (UFS IHMAI) for children in South Africa
Authors: Visser Marieta , Nel Riette , Van Aswegen Nicke , Basson Jana , Lochner Chante
Published: August 2024

Introduction: No standardised assessment instrument that covers all the components of in-hand manipulation (IHM) with evidence of instrument development and psychometric properties appropriate for South African children is currently available for occupational therapists. The University of the Free State In-Hand Manipulation Assessment Instrument (UFS IHMAI) is in the process of development to gain recognition as a standardised assessment instrument for children in South Africa. This article reports on the first and second stages of the face- and content validation process of the UFS IHMAI.
Method: A quantitative descriptive study design with a convenient sampling method was used. Participants provided their expert judgment by completing an EvaSys© online questionnaire.
Results: Fifty-five occupational therapists with experience in paediatric hand function, and registered with the HPCSA and OTASA participated. The participants agreed (above 80% consensus) that the instrument's content is relevant and representative to assess all components (separately and as a whole) of IHM that it was intended to measure. Participants' comments and practical recommendations will form an important knowledge-base for the instrument developers to use in the third stage of content validity, namely revising and refinement.
Conclusion: The results confirmed the face- and content validity of the UFS IHMAI and supported the further development and psychometric testing of the assessment instrument for children in South Africa.
 
Implications for practice:
This article builds upon prior studies in which therapists in South Africa have recognised the necessity for an in -hand-maniputation (IHM) assessment. It offers a concise overview of instrument development theory and delineates the iterative process employed in developing the first draft of the University of the Free State In-Hand Manipulation Assessment Instrument (UFS IHMAI). Additionally, this article furnishes background details regarding the proposed instrument's content, administration, and scoring guidelines. It also incorporates therapists’ perspectives as end-user, providing informed perceptions and consensus on the content validity of the proposed instrument. The suggestions provided by the participating therapist working within the South African context can be employed by the researchers to inform the revision, reconstruction, and refinement of the instrument. Subsequently, the revised version will undergo another round of content validity testing (with experts in instrument development, and in the field) and other psychometric testing. As instrument development is an iterative and ongoing refinement process, the implication of this research might only become apparent after further studies.
Destinasyon İmajı, Algılanan Değer, Turist Tatmini ve Davranışsal Niyet Arasındaki ilişki: Safranbolu Örneği
Authors: Canatar Ayşe , Koçoğlu Cenk Murat , Uğur İsa
Published: August 2024

Bu araştırma, Safranbolu Dünya Miras Kentini ziyaret eden yerli turistlerin destinasyon imajı, algılanan değer, turist tatmini ve davranışsal niyet arasındaki ilişkileri analiz etmeyi amaçlamaktadır. Bu amaç doğrultusunda, çalışmada nicel araştırma yöntemi kullanılmış ve veri toplama tekniği olarak anket tekniği tercih edilmiştir. Toplamda 410 yerli turistin dahil olduğu araştırmada SPSS programı kullanılarak elde edilen veriler analizlere tabi tutulmuştur. Verilerin analizinde, açıklayıcı faktör analizi, güvenirlik analizi, korelasyon ve regresyon analizlerinden yararlanılmıştır. Elde edilen bulgulara göre, destinasyon imajının; bilgi hizmetleri, yiyecekler ve turizm işletmeleri olmak üzere 3 alt boyuttan oluştuğu ve boyutların algılanan değeri olumlu yönde etkilediği sonucuna ulaşılmıştır. Benzer şekilde, algılanan değerin turist tatminini artırdığı ve aynı zamanda algılanan değerin davranışsal niyeti güçlendirdiği belirlenmiştir. Ayrıca, turist tatmininin davranışsal niyetle arasında pozitif bir ilişki tespit edilmiştir.
VASCULAR PLANTS OF THE EARLY MEDIEVAL SETTLEMENT LOCATED IN MAŁY BUCZEK NEAR LIPKA IN THE ZŁOTÓW COUNTY
Authors: Szczepański Mariusz R.
Published: August 2024

Abstract Introduction. An early medieval settlement was located on the Stołunia river in Mały Buczek (north-eastern part of the Wielkopolskie province). This historical monument is legally protected. The aim of the study was to inventory and analyze vascular plants. Material and methods. Field studies were conducted from March to October 2023. Vascular plants was analyzed in terms of geographical-historical and socio-ecological groups, life forms and frequency of occurrence. Results. A total of 104 vascular plant species belonging to 84 genera and 47 families were inventoried in the study area, including 25 species of woody plants. The most common families are Lamiaceae, Poaceae, Ranunculaceae and Rosaceae. Two species under partial and strict protection were found. Twenty most valuable trees were described, of which 8 were with monument circumferences. The most numerous category of life forms were hemicryptophytes (43%), geophytes (18%) and megaphanerophytes (13%). The geographical-historical group was dominated by native species (94%) over alien species (6%), among which kenophytes were predominant (5%). The flora is dominated by species of forest communities from the classes: Fagetalia, Prunetalia (49%), Quercion, Epilobion, Nardetalia (13%) and nitrophilic: Sambuco-Salicion, Alilarion (8%). Conclusion. The vascular plants of the early medieval settlement in Mały Buczek represent frequent, common and native species. There are few valuable, rare and protected plants. For two species a new locality in the Wielkopolska region has been recorded. The current study of the vascular plants in the early medieval settlement in Mały Buczek showed no traces of species related to former human activity.
Repercussions of the Anti-inflammatory Diet on Endometriosis Control
Authors: Sandriny Maria de Almeida Oliveira , Bianca Braga Gomes , Cainã Araújo Saraiva , Luana Azevedo Dourado , Jeremias Aguiar Azevedo , Sávio Benvindo Ferreira
Published: August 2024

Endometriosis is an inflammatory pathology characterized by the growth of endometrial tissue outside the uterus, resulting in chronic pelvic pain and infertility. As a result, it has been observed that diet can influence the pathophysiology of this disease by attenuating the inflammatory environment. In this context, this study aims to summarize the influence of diet as a complementary therapy for endometriosis. To this end, a narrative review was carried out using the BVS, Embase, and Cochrane databases, including articles available in full in Portuguese, English, and Spanish published in the last 5 years. According to the literature, a diet can have pro-inflammatory properties in patients with endometriosis, such as a diet rich in saturated fatty acids, and anti-inflammatory properties, involving polyunsaturated fatty acids, in order to influence the metabolism of prostaglandins. It is concluded that endometriosis is a chronic inflammatory disease that can be modulated with the adoption of anti-inflammatory dietary habits that can impact women’s quality of life in the long term.
Mouse brain, gut and plasma collection v2
Authors: Hecke Morais Livia
Published: August 2024

Protocol used in the Mazmanian lab for collecting brain and gut tissues and plasma from mouse for metabolomics. Protocol has been approved by the California Institute of Technology’s Institutional Animal Careand Use Committee (IACUC).
Zika NS5 RdRp His-SUMO construct small scale expression and purification protocol v1
Authors: Wang Korvus , fairhead michael , Williams Eleanor
Published: August 2024

This protocol details the co-expression and purification of Zika NS5 NS5 RNA-dependent RNA polymerase bearing a N-terminal His-SUMO tag at small scale (<6L).
Directed cardiac lineage differentiation of human pluripotent stem cells v1
Authors: Li Fan
Published: August 2024

Robust cardiac lineage differentiation from human pluripotent stem cells (hPSCs) holds great potential for regenerative medicine, disease modeling, and drug discovery. Adapted from previous protocols (Proc Natl Acad Sci U S A. 2012 Jul 3;109(27), PMID: 22645348; Cell Stem Cells, 2013 Jan 3;12(1):127-37, PMID: 23168164; Nature biotechnology. 2007 Sep;25(9):1015-24. PMID: 17721512; Nature protocols. 2017 Jan;12(1):15-31. PMID: 27906170), we present a robust monolayer protocol for efficiently generating both cardiomyocytes and cardiac fibroblasts from multiple human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) lines. This method involves the sequential modulation of key signaling pathways to mimic the stages of cardiac development. Prior to differentiation, hPSCs are maintained in a defined pluripotent state using a feeder-free culture system. Cardiac lineage differentiation is initiated by the temporal inhibition of GSK3, followed by treatment with Activin A and BMP4, directing these hPSCs toward a cardiac fate. These cardiomyocytes display spontaneous contractile activity and express markers for both pan-cardiomyocytes (e.g. TNNT2) and ventricular cardiomyocyte fates (e.g. IRX4 and MYH7).
Evercode Dual Index PCR v1
Authors: Rebboah Elisabeth , Biosciences Parse
Published: August 2024

This protocol describes the dual-index PCR procedure for Parse Biosciences Evercode WT and WT Mega v2 kits. Each subpool is barcoded with two Illumina indices on the 5' and 3' ends of the cDNA library. These indices acts as the fourth "round" of cell barcoding and must be included in the final cell ID/barcode in order to ensure unique barcodes across subpools within an experiment. The numerical ID and sequence of the Illumina barcode used for each subpool are recorded in experiment metadata and used downstream for subpool demultiplexing after the sequencing run.
HIGH-TECH ALGORITHMS FOR VISUALIZATION OF SALT-DOME TECTONICS ON SEISMIC DATA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, RUSACHENKO Natalia , KUZMENKO Pavlo ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: August 2024

Processing of seismic data, in the conditions of complex salt-dome tectonics of the Dnipro-Donetsk basin, requires special attention to the outline of the body of the salt shaft. The article is devoted to the analysis of methodological principles of applying high-tech seismic data processing algorithms, which have become industry standards in leading service geophysical companies, and in Ukraine are just beginning to be included in the seismic data processing workflow. The advantages of pre-stack depth migration compared to pre-stack time migration were described and one of them is absence of "pull up" and "push down" effects. In addition, the Reverse time migration (RTM) significantly improved the continuity of horizons, which is illustrated by data from the Dnieper-Donetsk basin. Full-waveform inversion (FWI) for visualizing the salt-dome tectonics and diapirs are described in detail. The integrated use of depth migration, RTM and FWI during the seismic data processing within the Romanian part of the Carpathians was considered. There is improvement of the resolution, the seismic horizons became more continuous, it bacame possible to avoid phase mismatch. Faults and salt bodies are also better visualized. Seismic data that maximally reflect the real geological environment can be obtained only as a result of a synergistic combination of perfect options for observation and processing systems, reliable velocity models, and modern migration algorithms as elements of technology in general. The complex application of these technologies demonstrates consistent geological results and creates prerequisites for the discovery of new deposits and hydrocarbon traps, which are confined to the zones of development of salt dome tectonics of the Dnipro-Donetsk basin.
SEISMIC-GEOLOGICAL ANALYSIS OF THE SOUTH CASPIAN MEGA DEPRESSION EVOLUTIONARY DEVELOPMENT TO IDENTIFY HYDROCARBON ACCUMULATIONS
Authors:   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, POGORELOVA Elena , ABDULLA-ZADA Murad ,   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, ABILHASANOVA Lala ,   SOCAR, Exploration Geophysics Department, Baku, Azerbaijan, SHIKHMAMMADOVA Telli ,   SOCAR, Exploration Geophysics Department, Baku, Azerbaijan
Published: August 2024

Background. The South Caspian Mega Depression (SCMD) is a territory limited in the west by the Dziruly massif, in the east by the Western Turkmenian Depression (inclusive), in the north by the mountain structures of the Greater Caucasus, Greater Balkhan and in the south restricted by the Lesser Caucasus, Talysh and Albours (including the aquatic area of the Southern Caspian) which in turn is related to the South Caspian oil and gas mega-basin. In the geodynamic model, the SCMD represents the Caucasian segment of the Alpine-Himalayan folded belt (its intermountain part) with elements of the active stage of development inherent in this area – earthquakes, sea level changes, mud volcanism, etc. Methods. This article examines the history of the development of SCMD based on data from geophysics, drilling, volcanology, geodynamics in order to identify accumulations of hydrocarbons. Seismogeological sections presented throughout the study area explain the complex geological structure and geodynamics, starting from the baikalian tectonic genesis and up to the present time. The clear boundaries of sedimentary basins and the island arcs surrounding them, which controlled lithology and stratigraphy, make it possible to predict probable petroleum source rock and oil and gas-producing rocks. Results. The construction of structural multi-temporal sediment surfaces in the Petrel program made it possible to trace the geological development of a certain segment (the South Caspian Aquatic Basin) of the studied territory, to clarify the influence of both long-lived deep and short-term local faults on the petrological composition of sediments and their thickness to determine the contours of possible objects of oil and gas formation. Conclusions. The approximation of the outlined oil and gas source rocks (by PetroMod modeling) stratigraphic units on the territory of Western Turkmenistan to the western part of the SCMD assumes the allocation of hydrocarbon sources in deep-submerged rocks in the rest of the territory. The combination of seismometry and volcanology data makes it possible not only to outline geological bodies on seismic profiles, but also to determine their density composition and chemistry by the speed of propagation of seismic waves.
ASSESSMENT OF THE INVESTMENT ATTRACTIVENESS OF NATIVE COPPER FORMATION OF THE VOLYN ORE REGION
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, MYKHAILOV Volodymyr , ANDREEVA Olena ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, SYDORCHUK Vitalii ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: August 2024

Background. Copper is one of the critical metals for the industry of Ukraine. More than 150 copper ore occurrences of various genetic types on the territory of Ukraine are known. One of the most interesting is the occurrences of native copper formation in the Riphean trappean formations of the Volyn copper ore district. To determine the degree of investment attractiveness of copper ore occurrences, an objective assessment of the resource base of the copper ore district is necessary. Methods. The analysis of the results of prospecting and economic assessment within the ore occurrences of the Volyn copper ore region were conducted: data on wells were reviewed, promising intervals were selected, areas were specified and copper ore resources were recalculated. Results. A recalculation of the resource potential of the Volyn copper ore region for three metallogenic areas: Volynsk, Kuhotsk-Volsk and Manevytsk was carried out. It was shown that their previous economic assessment during the exploration and assessment studies was overestimated by an order of magnitude. Сonclusions. It has been established that native copper mineralization of the Volyn copper ore region has not significant investment attractiveness and further development of its potential by future investors is associated with significant risks. The group of occurrences of the western border of the Hirnytsk horst (Zhyrychi, Zalysy-Shmenky) is of some interest, but the insignificant parameters of the ore bodies, their wide scattering over the area and across the section, the low copper content and the need for an underground method of mining call into question the economic feasibility of their development.
Clinical aspects of the applicability of biomarkers of acute kidney injury in ischemia-reperfusion in operative urology
Authors: Popov Sergey V. , Guseinov Ruslan G. , Sivak Konstantin V. , Perepelitsa Vitaliy V. , Bunenkov Nikolai S. , Lelyavina Tatiana A.
Published: August 2024

The development of acute kidney injury during surgical renal-preserving interventions characterizes the nature of the clinical course and prognosis for the development of chronic kidney disease. The use of standard indicators of disease progression (serum creatinine and urea nitrogen) in clinical practice can lead to unfavorable outcomes of acute kidney injury due to their low sensitivity and high specificity against the background of damage to more than 50% of the renal parenchyma). Other biomarkers of acute kidney injury (cystatin C, IL-18, KIM-1, NGAL, L-FABP, NAG and others) are superior to creatinine in sensitivity and specificity, but require additional research to identify the most optimal ones for clinical practice.
Boris N. Kholtsov (1861–1940): outstanding urologist, scientist, and teacher. To the 100th anniversary of the start of employment in the Urological Clinic of the Leningrad State Institute for Advanced Training of Doctors
Authors: Morgoshiia Temuri Sh. , Kuzmin Igor V.
Published: August 2024

This article is dedicated to outstanding clinical scientist Professor B.N. Kholtsov (1861–1940). The main stages of his scientific, clinical, and teaching activities and his scientific achievements in the development of novel methods for treating diseases of the urinary and male genital organs are presented. He was the first to propose a two-stage adenomectomy technique, an original method of urethral resection in case of stricture, and developed a surgical treatment method for contracture of the bladder neck. The role of Kholtsov in the training of urologists at the Department of Urology of the Leningrad State Institute for Advanced Training of Doctors, which he headed in 1926–1940, is shown. Kholtsov was a talented clinician, scientist, teacher, and innovator, whose main ideas remains in demand today.
CRESCIMENTO ECONÔMICO E DESENVOLVIMENTO NAS REGIÕES METROPOLITANAS DO BRASIL
Authors: Leite Helena de Oliveira , Ferrera de Lima Jandir
Published: August 2024

O objetivo desta pesquisa foi analisar a convergência do crescimento e do desenvolvimento socioeconômico das regiões metropolitanas (RMs) brasileiras no período de 2005 e 2016. Para tanto, empregou-se a metodologia dos coeficientes de variação com o intuito de identificar a convergência de renda e desenvolvimento socioeconômico entre os municípios das RMs. A comparação entre as RMs seguiu dois parâmetros: a convergência de crescimento econômico ou renda; e a convergência do desenvolvimento socioeconômico. Para a análise da convergência do crescimento econômico foram utilizadas como variáveis: o PIB per capita geral e por setor econômico (primário, secundário e terciário), estimado a partir do Valor Adicionado Bruto, enquanto para o desenvolvimento socioeconômico utilizou-se como parâmetro o Índice Firjan de Desenvolvimento Municipal (IFDM) em suas três dimensões:  emprego e renda, saúde e educação. Os resultados apontaram para o crescimento do PIB per capita em todas as RMs brasileiras, com maior concentração nas Regiões Centro-Oeste e Sul. O perfil do desenvolvimento socioeconômico também apresentou crescimento em todas as regiões, com maior concentração nas dimensões Saúde e Educação, porém com maior disparidade na dimensão Emprego e Renda.
INFLUÊNCIA DOS EIXOS ESTRUTURANTES DE TRANSPORTES NO VALOR DE IMÓVEIS NA CIDADE DE PALMAS-TO
Authors: Alves Amorim Rafael , Willamys Fernandes da Silva Antonio , dos Santos Fontes Pereira Bracarense Lilian , Nascimento da Paixão Adriano
Published: August 2024

O presente estudo busca analisar a influência que a variável quantitativa distância ao polo valorizante exerce na formação do valor de imóveis com o uso e ocupação do solo tipificado como posto de abastecimento de combustível, em Palmas-TO. A escolha da variável se baseia no ciclo do planejamento urbano e de transportes, segundo o qual, a melhoria da oferta de transporte influencia no valor do solo e induz mudança de uso a longo prazo. Buscando aferir a potencialidade da atuação da variável que prospecta a proximidade desses imóveis aos eixos estruturantes de transportes do município de Palmas-TO, utilizou-se o método comparativo direto de dados de mercado, amparado pela NBR 14.653-2 (2011), que possibilitou a determinação dos valores dos 3 (três) terrenos. Na primeira modelagem estatística a variável foi examinada e no segundo modelo, ignorada. Para oferecer um suporte a metodologia, a Teoria da Sintaxe Espacial foi utilizada para auxiliar nas análises configuracionais. Diante das modelagens estatísticas projetadas e analisadas, observou-se uma tendência de alavancagem no valor dos imóveis apreciados em razão da proximidade da infraestrutura de transporte referente as principais vias do município de Palmas-TO, sendo a vicinalidade à acessibilidade incorporada aos terrenos no momento da determinação de seus respectivos valores.
Cidade Resiliente: Mapeamento de indicadores de resiliência da cidade de Caxias do Sul 2024
Authors: Paese Giacomello Cintia , Cristina Fachinelli Ana , Libardi Bianca , de Atayde Moschen Suane , Paula Fermiano Ana , Ravizzoni Veronese Angélica , Luís Notari Daniel , Eberhardt Pereira Eduardo , Dal Bó Giancarlo , Benetti Corrêa da Silva Marcelo , Dalla Santa de Carvalho Mayron , Fabro Chinellato Patrícia , de Lucena Perini Rafael , Teodoro da Silva Ronei , Francisco Ferrigo Samuel , Capriolli Gonçalves Stéfani , Roveda Vanessa , de Tomasi Ribeiro Vinícius
Published: August 2024

O relatório de resiliência urbana de Caxias do Sul, elaborado pelo CityLivingLab da Universidade de Caxias do Sul em parceria com a Prefeitura, mapeia indicadores baseados em diretrizes internacionais. A pesquisa identifica desafios em desigualdade social, infraestrutura educacional e de saúde, além de vulnerabilidades econômicas. O relatório enfatiza a importância de dados completos e de uma abordagem integrada para fortalecer a resiliência urbana e garantir a sustentabilidade e bem-estar da cidade.
From crisis to coping: Exploring the psychosocial impact of COVID-19 on primary school children in developing country
Authors: Elmuttalut Mohammed
Published: August 2024

Primary school children are relatively vulnerable to the COVID-19 infection and its impact. This study aimed to assess the impact of COVID-19 on the psychosocial well-being of primary school children.

This was a descriptive cross-sectional study from March-August 2021. A sample of 285 children was randomly assigned by cluster random sampling. Children were interviewed using a pretested and validated questionnaire. The questionnaire is composed of questions related to demographic information and the psychosocial impact of COVID-19 on primary school children. Children’s responses were scored, and descriptive analyses were conducted with SPSS version 25.0 (IBM SPSS Statistics).

A total of 285 primary school children were interviewed. Children’s mean age was 13.2 ± 0.9 years old; 65.3% were males, 84.6% were from public schools, and 78.2% were in grade/class 8. 175 (61.4%) of participants reported that their daily lives had been disrupted by the COVID-19 pandemic, while 176 children (61.8%) avoided visiting crowded places; 59 children (20.7%) did not visit their friends, 90 children (31.6%) avoided public places, and 194 (68.1%) reported keeping their distance from people with influenza-like symptoms.

COVID-19 had a profound impact on the psychosocial well-being of primary school children. Addressing the gaps in children's understanding of COVID-19 and promoting proactive health behaviors through targeted education can significantly contribute to mitigating the psychosocial impact of COVID-19 on the primary school population. Future research and efforts to prioritize the appropriate strategies to mitigate the impact of COVID-19 on primary school children are extremely needed.
An ulnar artery of abnormal origin: A clinical case report
Authors: Garg Vedant , Biswas Jayanta
Published: August 2024

The deep ulnar artery was found originating from an unusual place just below the axilla in the left upper limb, which is extremely rare, and not much literature is present on it. The artery was on the most medial side which can get injured during various procedures and can be of clinical importance.
Isolation and identification of endophytic fungi from ocimum sanctum
Authors: Bhonsle Kaina Bhonsle
Published: August 2024

In this study, we aimed to isolate and identify endophytic fungi from the Ocimum sanctum plant, commonly known as Holy Basil and Hindi name- Tulsi.

1. To investigate the endophytic mycobiota from Ocimum sanctum. 2. To isolate and identify some endophytic fungi in selected medicinal plant. 3. To study phenotypic characteristics of endophytic fungi in selected medicinal plant.

Methods employed for the isolation and identification of endophytic fungal strains encompassed a multi-step approach, involving surface sterilization, tissue maceration, and subsequent fungal isolation. Morphological and microscopic characterization were utilized to identify the isolated fungal strains. As a result, a total of five distinct endophytic fungal strains were successfully isolated and identified.

The results revealed a high diversity of endophytic fungi associated with Ocimum sanctum. Furthermore, several potential bioactive compounds were detected in the isolated fungi, further emphasizing their importance.

This study contributes to the knowledge of endophytic fungi associated with Ocimum sanctum and provides a foundation for further investigation into their biotechnological potential.
Assessment of prescription pattern and cost effective analysis of oral hypoglycemic agents used in treatment of type 2 diabetes mellitus
Authors: Manapurthu Maha George , Deepashree C  , Pradeep Roopali , Nivedha Maria
Published: August 2024

Diabetes mellitus treatment that is cost-effective not only ensures rational drug use but also lowers patient costs. When a cost-effectiveness tool is used correctly in therapeutic decision making, the disease's complications are reduced, and the patients' quality of life is improved. This study aims to evaluate the prescribing patterns and to carry out cost effective analysis for Oral Hypoglycaemic agents used in the treatment of Type 2 Diabetes Mellitus.

A Prospective, observational study was carried out in the out-patient department of a Diabetes Specialty Centre-Bangalore for a period of 9 months. Individuals aged 18 and above and clinically diagnosed with T2DM with or without HTN and dyslipidaemia were considered eligible for the study. Individuals who were on Insulin for management and those with other types of Diabetes were excluded from the study.

A total of 274 prescriptions were evaluated. The majority of the patients belonged to the age group of 60 years and older (55%). Prevalence of Diabetes were found to be more in men (53%) when compared to women (47%). Most of the study subjects were diagnosed with HTN + T2DM (35%) followed by T2DM+HTN+ Dyslipidaemia (27%). The average number of drugs per prescription were 2.04. It was observed that Sulphonylureas, Biguanides, Alphaglucosidase inhibitors, DPP-4 inhibitors, Thiazolidinediones and SGLT2 inhibitors were the numerous drugs prescribed to the study population. Incremental Cost Effectiveness Ratio (ICER) was calculated and it was found that DPP-4 inhibitors are cost effective in monotherapy while DPP-4 inhibitors+ Biguanides for double combination therapy and DPP-4 inhibitors+SGLT2 inhibitors + Biguanides in three combination was found to be cost effective.

In our study, it was observed that Metformin was most commonly prescribed among the OHA and DPP-4 inhibitors are cost effective. Polypharmacy is a big issue, especially for the elderly population. This study provides the baseline data for carrying out further researches on prescription patterns as well as cost effective analysis including all costs in health care settings.
Development and Characterization of C355.0 Alloy Composite for Automotive Applications - A Review
Authors: Rajesh T. R. , Venkata Narayana B. , Sunil Kumar M. , Natarajan T.
Published: August 2024

Aluminum-based hybrid metal matrix composite plays an important role in the development of the industrial and automobile sectors. Because of satisfying the demands of advanced applications, such as lightweight and strength, easy to cast and less expensive compared to conventional materials. These required properties are primarily being obtained by selecting proper matrix reinforcement phase and manufacturing methods and the properties can be further increased by using suitable heat treatment methods recommended for the specific matrix phases. This paper reviews the effect of the different casting methods and heat treatment conditions on the mechanical and tribological properties of the C355.0 alloy. out of available casting techniques, the stir casting method was identified as the best method to cast C355.0 alloy to increase the mechanical properties and microstructure further, a heat treatment process was also discussed, which govern the dispersion of reinforcements over the matrix, and affects the mechanical, tribological properties of the composite. This work may guide researchers to select appropriate casting methods for manufacturing matrix and heat treatment methods to enhance the mechanical and tribological property in order full fill the requirements in the different areas of composite developments.
Comprehensive Study on Sizing of Hybrid Renewable Energy System Using Commercial Software
Authors: Mahapatra Arunima , Pal Nitai
Published: August 2024

To fulfil the ever-rising demand for energy, it is imperative to use all available energy sources. Renewable energy sources are clean, abundant, and non-polluting, but their intermittent nature is a drawback. A hybrid energy system, a combination of renewable energies, is employed to solve this issue. In-depth literature reviews of recently released papers in the subject of hybrid renewable energy are presented and analyzed in this work. A review on sizing hybrid system for renewable energy using commercial software is done and presented in this paper.
Purification of Glycerol Obtained during Biodiesel Synthesis and Production of Value - Added Product
Authors: Omkaresh B. R. , Suresh R. , Lalithamba H. S. , Shreyas T. S. , Ujval C. L. , Sudharshan B. K. , Srihari
Published: August 2024

Globally biodiesel is one of the best alternative fuels, and is seeing an exponential increase in demand. Despite the bright prospect of biodiesel production, efforts to commercialize it has been very limited. One of the major obstacles has been the high price associated with total production costs. Thus, it is necessary to reduce its processing cost to make biodiesel production feasible. This can be achieved by giving a value-added application for its byproduct. Glycerol is produced as an approximately 10-15% as a byproduct of the transesterification of triglycerides. Glycerol is a valuable byproduct obtained during biodiesel production but it is obtained in a crude form limiting its application. This byproduct needs to be purified efficiently to utilize it. Therefore, the present work aims to report phases in which the crude glycerol is purified. There are two phases in which the crude glycerol is purified. The Crude Glycerol is processed through saponification and then neutralization in the first phase. This produces three layers from which partly purified glycerol is obtained through separation. In the second phase of purification, the glycerol layer is separated from various salt impurities by the use of non-polar solvents. This glycerol is then extracted from the solvent and is subjected to decolorization using charcoal. Soaps and detergents are prepared as a valueadded product from the obtained glycerol.
Essence of PPC (Production, Planning and Control) in Enhancing Productivity at Fly Ash Brick Manufacturing Industry
Authors: Chakraborty Abhijit , Bhattacharjee Indrajit , Chakraborty Nilmoni
Published: August 2024

Effective upkeep of equipment and facilities When it comes to the day-to-day operations of the industry that manufactures fly ash bricks, accurate planning and the scheduling of work are of the utmost importance in order to increase overall production. It is necessary to have a work force that has been appropriately trained in order to achieve successful maintenance optimization. Additionally, it is necessary to have management that is efficient in addition to an organisational structure. In order for the job to be completed successfully, it is vital that the key resources needed by the fly ash brick business be employed in an efficient and effective manner. This is necessary in order for the task to be completed. This is due to the fact that the industry is dependent on these resources in order to do the task. In this section of the essay, we are going to discuss the process of working, beginning with work initiatives.
Microplastics as Vectors for Metals from Mines and Fuels: Environmental Pathways and Implications
Authors: Vaijayanthimala S. , Sharma Kalpana
Published: August 2024

Microplastics can interact with metals, mines, and fuels in the environment through various pathways, including contaminant sorption, transport, bioaccumulation, and toxicological impacts. Understanding these interactions is crucial for assessing the environmental risks associated with microplastics and developing effective strategies for pollution mitigation and environmental remediation. Due to their widespread use in modern society and aquatic systems, micro/nano plastics, a subset of plastics with an effective width less than 5 mm, have emerged as a new type of micro contaminant. These tiny fragments of tarnished microplastic beads from cosmetic products, particularly from detergents and shampoos, have been discovered by researchers to be present in air, soil, lakes, and even the oceans. The pollution of our environment with microplastics is seen as a severe threat to ecosystems, particularly aquatic environments. The negative impacts of microplastic pollution can be effectively reduced by excluding them at the locations where they are discharged. Although the waste water treatment systems of today, are capable of eliminating microplastic to a limited extent. Due to their structural flexibility and multifunctionality, nanomaterials are being utilised more frequently today to treat drinking water and wastewater, which increases treatment efficiency. In particular, the versatile properties of nanomaterials have been employed to create high performance adsorbent and use it as a photocatalyst for removing microplastic from an aqueous environment. This review examines the removal and effects of microplastics while providing proactive ways to deal with any process bottlenecks.
An Analytical Treatment on Coriolis Force and Non- Uniform Temperature Gradient for Isotropic and Anisotropic Free Convection in Porous Channel
Authors: Girish E. , Dinesh P. A. , Madhur D. H. , Mayur D. H. , Manjunatha N. J. , Sumithra R.
Published: August 2024

The effects of Coriolis force and non-uniform temperature gradient on the onset of convection in a horizontal rectangular channel filled up with an incompressible fluid fully saturated with anisotropic porous media is studied by means of linear stability analysis. We derive the critical Rayleigh number expression analytically, the assumptions made in this study are, the walls of the conducting channels are considered to be impermeable and are good thermal conductors to maintain un-uniform temperature gradient vertically. The solution of the problems is found using the method of Fourier series with the coefficients as functions of horizontal co-ordinate. It is found that the effect of rotation in anisotropic porous permeability and thermal diffusivity have a significant effect on the Rayleigh number and the steady flow patterns and the effect of rotation more often destabilises the system and the Critical Rayleigh number is determined.
Damage Localization in a Beam by Lifting Wavelet Scheme and Photographic based Experimentation
Authors: Nigam Ravi , Kumar Ramnivas , Parida Nisit Kumar , Kumar Ranjan , Ghosh Soumya , Paul Sayan
Published: August 2024

The structures under fatigue loading are fault prone. The damage reduces the local stiffness. This local stiffness leads to a slope discontinuity in the structure's elastic line. Localizing the local discontinuity reveals the location of the damage. Wavelet transform is a powerful tool to localize a local slope discontinuity in a signal. The major challenges in the localization of damage in a beam are obtaining the high spatial resolution beam deflection and eliminating the border distortion. The high spatial resolution shrinks the border distortion as well as gives more localized crack detection. The reduced border distortion leads to the detection of cracks very close to the ends of the beam. In the present work, finite element analysis is used for getting the simulated beam deflection. The lifting wavelet is used for the localization of cracks in the beam. The lifting wavelet has certain advantages over the classical wavelet. The lifting wavelet possesses perfect reconstruction and a narrower border distortion zone. A comparative study is presented between the discrete wavelet transform and the lifting wavelet transform for localizing the crack. The ability of lifting wavelet is tested for different noise conditions and multiple crack localization. A photographic method is used to get the high-resolution of experimental beam deflection of stainless-steel material.
Cultivating Character in The Digital Age: Umar Ibn Ahmad Bārājā's Moral Education Framework for Society 5.0
Authors: Muntakhib Ahmad , Mustolehudin Mustolehudin , Taruna Mulyani Mudis , Dahri Harpandi
Published: August 2024

The era of society 5.0 provides new challenges for Islamic education, especially in moral education. One of the scholars who has great attention to moral education is Umar Ibn Ahmad Bārajā. This study seeks to describe and analyze the thoughts of Umar Ibn Ahmad Bārajā in the books Akhlaq li al-Banin and Akhlak li al-Banat on moral education which is very interesting to be projected in the era of society 5.0. The focus raised is how moral education from the perspective of Umar Ibn Ahmad Bārajā, the values contained in moral education and Umar Ibn Ahmad Bārajā's moral education strategy in the era of Society 5.0. This research is a qualitative study with a research focus on the thoughts of Umar Ibn Ahmad Bārajā in the books Akhlaq li al-Banin and Akhlak li al-Banat. This thought is analyzed by content analysis and then projected in the era of Society 5.0. There are three research findings. First, good morals must begin to be built in education carried out by families that are strengthened by educational institutions. Second, the values instilled are respecting and honoring both parents, teachers, all elders, Honest in speaking, Tawadlu', Patience, Not avoiding each other, Not quarreling, and Not raising your voice when talking or laughing. Third, the use of gender-based names, habits, homework and role modeling.
Implementation of Change Management in Shaping Student Character in the MAPK Program at MAN 1 Yogyakarta
Authors: Nudin Burhan , Salsabil Shoffiyah , Zainuddin Nurkhamimi , Septianto Mukhammad Eko , Husain Andi Musthafa , Saputra Nadar
Published: August 2024

This article discusses the implementation of change management in character education at MAN 1 Yogyakarta, focusing on developing skilled individuals with leadership qualities and the ability to tackle global competition challenges. In the current evolving landscape, where global competition has intensified, students in Indonesia are facing demanding requirements. This research is a case study using a qualitative descriptive method. Besides academic excellence, students also need to possess "soft skills" and "hard skills" that are essential for keeping up with the times. Soft skills such as communication, leadership, and teamwork are crucial in a collaborative work environment. On the other hand, hard skills such as technological proficiency and foreign language skills provide the necessary competitive advantage. To meet these demands, Indonesian education needs to focus on developing both foundational aspects and specific expertise. MAN 1 Yogyakarta recognizes this need and has taken steps to prepare its students according to the required standards of change. They implement programs such as basic leadership training (LDK) and establish a special student organization called OSAKA (Organisasi Siswa Madrasah Aliyah Program Keagamaan) to enhance students' leadership skills, discipline, and sense of responsibility. This activity is a flagship program aimed at enhancing students' abilities in communication, discipline, and leadership. There are also by participating in clubs and organizations such as the Intra-School Student Organization (OSIS), Indonesian Red Cross Youth (PMR), Islamic Spiritual (ROHIS), Scouts, and scientific clubs, students also learn the importance of responsibility and discipline in fulfilling their roles within these organizations.
The History of Sunan Bonang Mandala in The Lasem Chronicle (Carita Lasem)
Authors: Fahmi Muhammad Nabil , Anggarini Ida Fitri , Hoque Obaidul
Published: August 2024

This article aims to reveal the existence and origins of the establishment of the Sunan Bonang Mandala as narrated in the Carita Lasem text or the Lasem Chronicle. This descriptive-qualitative research employs content analysis methods to analyze the content and socio-historical context within the Lasem Chronicle text. Through content analysis and comparison with other historical data, this research concludes the strong hypothesis of the existence of the Sunan Bonang Mandala in Bonang Village, Lasem District, Rembang Regency. Sunan Bonang. As local historiography, the Lasem Chronicle shows the existence of an Islamic educational center led by Sunan Bonang in the 15th century AD. This text also emphasizes Sunan Bonang's position as a state saint whose missionary territory covers the areas of Tuban, Lasem, and their surroundings. Furthermore, the origins of the establishment of the Sunan Bonang Mandala in the Lasem Chronicle also depict a pattern of Islamic Mandala establishment during the Wali Songo period, where the establishment of Mandala is inseparable from the role of local sovereigns, simultaneously illustrating a positive pattern of sovereign-religious leader relations in the Islamization process in the Nusantara.
Preliminary Efficacy of the Transdiagnostic EMDR-Negative Affect Protocol
Authors: Carbajal Jose , Horne Taija L. , Ponder Warren N. , Sieja Lauren I. , Collins Christy R.
Published: August 2024

First responders and their dependents must cope with the stress from their occupational duties. Those who present for treatment can be overwhelmed by their affective display. In this study, we used a mixed methods design with two first responders and the widow of a first responder. We used the Positive and Negative Affect Schedule measure to identify the negative affect and tested the Eye Movement Desensitization and Reprocessing-Negative Affect protocol, which directly targets the negative affect. From baseline to the end of treatment, all three clients had a clinically significant reduction in negative affect, and at 3-month follow-up, the two first responders had a significant reduction in negative affect. There was also a decrease in scores on attachment, depression, generalized anxiety, suicidality, and posttraumatic stress symptoms, as well as an increase in scores on resilience. The findings show promising results; however, the protocol needs randomized controlled trials with first responders and veteran populations in larger sample sizes to prove its efficacy.
ASSYST-Individual Adapted for the Treatment of Obsessive-Compulsive Disorder
Authors: Martínez Cáceres Gonzalo , Premuda-Conti Paola
Published: August 2024

Clients with obsessive-compulsive disorder (OCD) symptoms pose a challenge for psychotherapists. Current evidence-based treatments have limitations in efficacy and client retention. This article reports on 17 cases treated with the Acute Stress Syndrome Stabilization Individual (ASSYST-I) Adapted for OCD in an outpatient mental health clinic in Uruguay. The average number of sessions was 16. Clients completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) to assess OCD symptom severity before and after treatment. Wilcoxon signed-rank tests found significant differences between pre- and posttreatment on the Y-BOCS total scores (z= −3.624,p< .001), obsessions subtotal scores (z= −3.627,p< .001), and compulsions subtotal scores (z= −3.624,p< .001). This study describes the ASSYST-I Adapted for OCD and discusses its preliminary safety, feasibility, and acceptability.
Mengajar dengan Cerita: Pendekatan Berbasis Narasi dalam Pendidikan Pra-Sekolah yang Menyenangkan dan Ramah Anak
Authors: Munafiah Nida'ul , Nirmala Ine , Ferianto  , Astuti Ria , Munir Misbachol
Published: August 2024

Pre-school education has a crucial role in forming the basis of children's development. This research aims to explore and describe teaching with stories: a narrative-based approach in a fun and child-friendly pre-school learning process at Nur Faqih Kindergarten, East Karawang. This approach is not only directed at delivering learning material, but also creates a fun and child-friendly learning experience and utilizes the power of stories as a learning tool to increase children's enjoyment, involvement and understanding. Qualitative research methods are used with data collection techniques through observation, interviews and documentation analysis. The research results show that the use of a narrative-based approach in Nur Faqih Kindergarten makes a positive contribution to the development of cognitive, social and emotional skills of pre-school children. Stories integrated into learning not only increase children's interest, but also support language development, creativity and problem solving. This narrative-based approach not only creates a fun learning environment, but also helps children understand moral and ethical values through the stories told. Thus, this research contributes to the development of more innovative and interesting learning strategies at the pre-school level.