bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating pulmonary and non-infectious complications in common variable immunodeficiency disorders: a UK national multi-centre study
Authors: Bintalib Heba M. , Grigoriadou Sofia , Patel Smita Y. , Mutlu Leman , Sooriyakumar Kavitha , Vaitla Prashantha , McDermott Elizabeth , Drewe Elizabeth , Steele Cathal , Ahuja Manisha , Garcez Tomaz , Gompels Mark , Grammatikos Alexandros , Herwadkar Archana , Ayub Rehana , Halliday Neil , Burns Siobhan O. , Hurst John R. , Goddard Sarah
Published: September 2024

Background

Common Variable Immunodeficiency Disorders (CVID) encompass a spectrum of immunodeficiency characterised by recurrent infections and diverse non-infectious complications (NICs). This study aimed to describe the clinical features and variation in NICs in CVID with and without interstitial lung disease (ILD) from a large UK national registry population.

Methods

Retrospective, cross-sectional data from a UK multicentre database (previously known as UKPIN), categorising patients into those with CVID-ILD and those with NICs related to CVID but without pulmonary involvement (CVID-EP; EP= extra-pulmonary involvement only).

Results

129 patients were included. Chronic lung diseases, especially CVID-ILD, are prominent complications in complex CVID, occurring in 62% of the cohort. Bronchiectasis was common (64% of the cohort) and associated with greater pulmonary function impairment in patients with CVID-ILD compared to those without bronchiectasis. Lymphadenopathy and the absence of gastrointestinal diseases were significant predictors of ILD in complex CVID. Although the presence of liver disease did not differ significantly between the groups, nearly half of the CVID-ILD patients were found to have liver disease. Patients with CVID-ILD were more likely to receive immunosuppressive treatments such as rituximab and mycophenolate mofetil than the CVID-EP group, indicating greater need for treatment and risk of complications.

Conclusion

This study highlights the significant burden of CVID-ILD within the CVID population with NICs only. The lungs emerged as the most frequently affected organ, with ILD and bronchiectasis both highly prevalent. These findings emphasise the necessity of a comprehensive and multidisciplinary approach in managing CVID patients, considering their susceptibility to various comorbidities and complications.
First record of the family Callianopsidae (Decapoda: Axiidea) and a new species of Vulcanocalliax from the Hikurangi Margin off Aotearoa New Zealand, with a key to species of Callianopsidae
Authors: Schnabel Kareen E. , Peart Rachael A.
Published: September 2024

Introduction

The Aotearoa New Zealand ghost shrimp of the infraorders Axiidea and Gebiidea have never been comprehensively reviewed, with recent work uncovering a diverse regional fauna representing eight of the 14 known families.

Methods

Using standard morphological and DNA sequencing tools, the family Callianopsidae is, for the first time, recorded off New Zealand, represented by a new species of Vulcanocalliax.

Results

The new species was found near hydrocarbon seeps on the Hikurangi Margin, on the eastern New Zealand continental slope, and is only the second species now known in this genus. The single congener, V. arutyunovi, is only known from a mud volcano in the Gulf of Cádiz, off the Iberian Peninsula. Vulcanocalliax sp. nov. was formerly reported as an unnamed host of a new endemic New Zealand rhizocephalan barnacle Parthenopea australis and is here formally described as Vulcanocalliax beervana sp. nov.

Discussion

The new species differs, e.g., in the shape of the anterior carapace margin (convexly rounded and without elevated postantennal shoulder present in V. arutyunovi), the ocular peduncle having a convex anterolateral margin (compared to a straight margin), and the uropodal exopod has a dorsomedian ridge, lacking the elevated anterior portion that is distinct in V. arutyunovi. This brings the number of described New Zealand ghost shrimp species to 18. A key to all known Callianopsidae is provided.

ZOOBANK

LSID urn:lsid:zoobank.org:pub:4EDE6CE1-B644-4FFB-94CA-C8725A7549DD.
Acoustic mapping reveals macroalgal settlement following a retreating glacier front in the High Arctic
Authors: Gonzalez Triginer Victor , Beck Milan , Sen Arunima , Bischof Kai , Damsgård Børge
Published: September 2024

Vegetated coastal marine ecosystems are projected to expand northwards in the Arctic due to climate change, but the mechanisms for this expansion are complex and nuanced. Macroalgal biomass in the littoral areas of Svalbard has been increasing, but data at the glacier fronts are very scarce. In this study, we use hydroacoustics and video validation from an unmanned surface vehicle to survey macroalgal bed distribution along the coast of a High Arctic fjord (Billefjorden, Svalbard), including river bays and land- and sea- terminating glacier fronts, as well as oceanographic measurements to indicate physical drivers of macroalgal settlement. We found high variation of macroalgal coverage along the fjord coastline, with virtually no macroalgae in the river bays but abundant coverage in areas with little terrestrial runoff. Furthermore, the presence of kelp was found at the land-terminating glacier front which has recently retreated from the sea, which suggests the potential for rapid macroalgal establishment in newly available substrate following glacial retreat. These findings suggest large ecological implications throughout the Arctic, in which macroalgal expansion may lead to significant changes in the underwater coastal landscape and ecosystem. This study shows that the use of remote autonomous vehicles and hydroacoustic mapping with video validation has a high potential for sustainable and efficient ecological monitoring.
Closed–loop oxygen usage during invasive mechanical ventilation of pediatric patients (CLOUDIMPP): a randomized controlled cross-over study
Authors: Atakul Gulhan , Ceylan Gokhan , Sandal Ozlem , Soydan Ekin , Hepduman Pinar , Colak Mustafa , Zimmermann Jan M. , Novotni Dominik , Karaarslan Utku , Topal Sevgi , Aǧin Hasan
Published: September 2024

Background

The aim of this study is the evaluation of a closed-loop oxygen control system in pediatric patients undergoing invasive mechanical ventilation (IMV).

Methods

Cross-over, multicenter, randomized, single-blind clinical trial. Patients between the ages of 1 month and 18 years who were undergoing IMV therapy for acute hypoxemic respiratory failure (AHRF) were assigned at random to either begin with a 2-hour period of closed-loop oxygen control or manual oxygen titrations. By using closed-loop oxygen control, the patients' SpO2 levels were maintained within a predetermined target range by the automated adjustment of the FiO2. During the manual oxygen titration phase of the trial, healthcare professionals at the bedside made manual changes to the FiO2, while maintaining the same target range for SpO2. Following either period, the patient transitioned to the alternative therapy. The outcomes were the percentage of time spent in predefined SpO2 ranges ±2% (primary), FiO2, total oxygen use, and the number of manual adjustments.

Findings

The median age of included 33 patients was 17 (13–55.5) months. In contrast to manual oxygen titrations, patients spent a greater proportion of time within a predefined optimal SpO2 range when the closed-loop oxygen controller was enabled (95.7% [IQR 92.1–100%] vs. 65.6% [IQR 41.6–82.5%]), mean difference 33.4% [95%–CI 24.5–42%]; P < 0.001). Median FiO2 was lower (32.1% [IQR 23.9–54.1%] vs. 40.6% [IQR 31.1–62.8%]; P < 0.001) similar to total oxygen use (19.8 L/h [IQR 4.6–64.8] vs. 39.4 L/h [IQR 16.8–79]; P < 0.001); however, median SpO2/FiO2 was higher (329.4 [IQR 180–411.1] vs. 246.7 [IQR 151.1–320.5]; P < 0.001) with closed–loop oxygen control. With closed–loop oxygen control, the median number of manual adjustments reduced (0.0 [IQR 0.0–0.0] vs. 1 [IQR 0.0–2.2]; P < 0.001).

Conclusion

Closed-loop oxygen control enhances oxygen therapy in pediatric patients undergoing IMV for AHRF, potentially leading to more efficient utilization of oxygen. This technology also decreases the necessity for manual adjustments, which could reduce the workloads of healthcare providers.

Clinical Trial Registration

This research has been submitted to ClinicalTrials.gov (NCT05714527).
Analysis of the current status and hot topics in spinal schwannoma imaging research based on bibliometrics
Authors: Abudueryimu Abudunaibi , Shoukeer Kutiluke , Ma Haihong
Published: September 2024

Objective

This study aims to explore the current hot topics and future research trends in spinal schwannoma imaging research, providing a reference for related studies and promoting the development of spinal schwannoma imaging.

Methods

We conducted a literature search in the Web of Science database using the search terms (((TS = (Spinal schwannoma)) AND TS = (Imaging)) OR TS = (Spinal schwannoma)) AND TS = (image) to retrieve relevant articles. The collected data, including authors, keywords, journals, countries, institutions, and references, were subjected to visual analysis using the visualization software CiteSpace 6.4.2R and VOSviewer 1.6.19.

Results

A total of 310 relevant articles were identified. After further screening based on time limits, inclusion, and exclusion criteria, 179 articles were included in the study, consisting of 132 original articles and 42 reviews. These articles were authored by 1,034 authors from 35 countries and 324 institutions and were published in 82 different journals. The included articles cited a total of 6,583 references from 1,314 journals.

Conclusion

Although the field of spinal schwannoma imaging research is not a popular research area in the medical community, there has been an increasing international interest in this field in recent years. While China ranks high in terms of the number of published articles, there is still a gap in terms of the quality and research level compared to developed countries in Europe and America. MRI, as the gold standard for diagnosing spinal schwannomas, is expected to be a research hotspot in terms of feature analysis, enhancement characteristics, and quantitative analysis. It is also hoped that China can increase its investment in research and contribute to the field by publishing high-quality articles in the future.
Improving growth in preterm infants through nutrition: a practical overview
Authors: De Rose Domenico Umberto , Maggiora Elena , Maiocco Giulia , Morniroli Daniela , Vizzari Giulia , Tiraferri Valentina , Coscia Alessandra , Cresi Francesco , Dotta Andrea , Salvatori Guglielmo , Giannì Maria Lorella
Published: September 2024

The primary purpose of this practical overview is to provide a practical update on appropriate nutritional strategies to improve growth in preterm infants. Current recommendations for improving preterm growth concern both macronutrients and micronutrients, with tailored nutrition since the first days of life, particularly when fetal growth restriction has been reported. Human milk is undoubtedly the best nutrition for all newborns, but, in some populations, if not adequately fortified, it does not adequately support their growth. In all preterms, growth should be correctly monitored weekly to intercept a negative trend of growth and implement nutritional strategies to avoid growth restriction. Similarly, growth should be accurately supported and monitored after discharge to improve long-term health consequences.
Exploring genetic associations between metabolites and atopic dermatitis: insights from bidirectional Mendelian randomization analysis in European population
Authors: He Ao , Hong Zhisheng , Zhao Xinqi , Li Hainan , Xu Ying , Xu Yangheng , Jing Zhaoyi , Ma Haoteng , Gong Zhuo , Yang Bing , Zhou Qingzhu , Zheng Fan , Zhao Xian
Published: September 2024

Introduction

There is growing evidence indicating a complex interaction between blood metabolites and atopic dermatitis (AD). The objective of this study was to investigate and quantify the potential influence of plasma metabolites on AD through Mendelian randomization (MR) analysis.

Methods

Our procedures followed these steps: instrument variable selection, primary analysis, replication analysis, Meta-analysis of results, reverse MR analysis, and multivariate MR (MVMR) analysis. In our study, the exposure factors were derived from the Canadian Longitudinal Study on Aging (CLSA), encompassing 8,299 individuals of European descent and identifying 1,091 plasma metabolites and 309 metabolite ratios. In primary analysis, AD data, was sourced from the GWAS catalog (Accession ID: GCST90244787), comprising 60,653 cases and 804,329 controls. For replication, AD data from the Finnish R10 database included 15,208 cases and 367,046 controls. We primarily utilized the inverse variance weighting method to assess the causal relationship between blood metabolites and AD.

Results

Our study identified significant causal relationships between nine genetically predicted blood metabolites and AD. Specifically, 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) (OR = 0.92, 95% CI 0.89–0.94), 1-methylnicotinamide (OR = 0.93, 95% CI 0.89–0.98), linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] (OR = 0.94, 95% CI 0.92–0.96), and 1-arachidonoyl-GPC (20:4n6) (OR = 0.94, 95% CI 0.92–0.96) were associated with a reduced risk of AD. Conversely, phosphate / linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] (OR = 1.07, 95% CI 1.04–1.10), docosatrienoate (22:3n3) (OR = 1.07, 95% CI 1.04–1.10), retinol (Vitamin A) / linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] (OR = 1.08, 95% CI 1.05–1.11), retinol (Vitamin A) / linoleoyl-arachidonoylglycerol (18:2/20:4) [1] (OR = 1.08, 95% CI 1.05–1.12), and phosphate / linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] (OR = 1.09, 95% CI 1.07–1.12 were associated with an increased risk of AD. No evidence of reverse causality was found in the previously significant results. MVMR analysis further confirmed that 1-palmitoyl-2-stearoyl-GPC (16:0/18:0) and 1-methylnicotinamide are independent and dominant contributors to the development of AD.

Conclusion

Our study revealed a causal relationship between genetically predicted blood metabolites and AD. This discovery offers specific targets for drug development in the treatment of AD patients and provides valuable insights for investigating the underlying mechanisms of AD in future research.
Genetically predicted metabolites mediate the association between lipidome and malignant melanoma of skin
Authors: Wu Yuzhou , Ma Hang , Liu Zhenyu
Published: September 2024

Objective

To investigate the causal relationship between lipidome and malignant melanoma of skin (MMOS), while identifying and quantifying the role of metabolites as potential mediators.

Methods

A two-sample Mendelian randomization (MR) analysis of lipid species (n=7174) and MMOS was performed using pooled data from genome-wide association studies (GWAS). In addition, we quantified the proportion of metabolite-mediated lipidome effects on MMOS by two-step MR.

Results

This study identified potential causal relationships between 11 lipids and MMOS, and 40 metabolites and MMOS, respectively. Phosphatidylethanolamine (18:0_18:2) levels mined from 179 lipids by MR Analysis increased the risk of MMOS (OR: 1.962; 95%CI:1.298,2.964; P=0.001). There is no strong evidence for a relationship between genetically predicted MMOS and phosphatidylethanolamine (18:0_18:2) levels (P=0.628). The proportion of gene predictions for phosphatidylethanolamine (18:0_18:2) levels mediated by 1-stearoyl-(glycosylphosphatidylinositol) GPI (18:0) levels was 12.40%.

Conclusion

This study identifies 1-stearoyl-GPI (18:0) levels as a potential mediator that may mediate the causal relationship between phosphatidylethanolamine (18:0_18:2) levels and MMOS, This provides direction for the investigation of MMOS, but further research of other possible potential mediators is still needed.
CD276 as a promising diagnostic and prognostic biomarker for bladder cancer through bioinformatics and clinical research
Authors: Zhou Qi , Xu Jianhao , Chen Xuelei , Ouyang Jun , Mao Caiping , Zhang Zhiyu
Published: September 2024

Objective

To assess CD276 expression and explore its relationship with the clinicopathological characteristics and prognosis of patients with bladder cancer.

Methods

In total, RNA-sequencing data and clinical profiles of 436 bladder cancer cases from The Cancer Genome Atlas (TCGA) were assessed using the University of California Santa Cruz Xena (UCSC) platform. We compared the CD276 levels in cancerous and adjacent normal tissues and used the R software for statistical association with the clinical stage, grade, and survival (the overall survival, disease-specific survival, and progression-free survival). A single-gene GSEA analysis on TCGA-BLCA data was performed to explore potential pathways through which CD276 might influence bladder cancer. Additionally, CD276 expression was analyzed by comparing data from 9 cancerous tissues and 3 adjacent normal tissues in the GEO dataset GSE7476. Furthermore, we analyzed 133 cancerous bladder and adjacent tissue samples from the Soochow University Hospital, collected between January 1, 2016, and September 30, 2022, to assess the CD276 protein expression using immunohistochemistry. We examined the relationship between tumor CD276 levels and clinical outcomes and prognosis of bladder cancer.

Results

Bioinformatic analysis revealed elevated CD276 expression in tumors compared to that in adjacent tissues (p<0.05), correlating with poor survival. GSEA revealed that CD276 was significantly involved in extracellular matrix-related pathways. Immunohistochemistry confirmed CD276 overexpression in tumor tissues, with higher levels linked to advanced pathological grades and worse prognosis.

Conclusion

CD276 is markedly upregulated in bladder cancer and associated with severe pathological features, advanced disease, potential for metastasis, and diminished survival rates. It may promote bladder cancer development and progression by influencing extracellular matrix-related-related pathways, making it a viable diagnostic and prognostic biomarker for bladder cancer.
Evaluation of the thickness of acetabular cartilage by ultrasound in developmental dysplasia of the hip
Authors: Hong Kai , Wan Jie , Zhao Ying , Zhang Chao
Published: September 2024

Introduction

It has been reported that the cartilaginous roof of the acetabulum is thicker in infants with developmental dysplasia of the hip (DDH) than in those with healthy hips. However, there is limited research on the changes in the thickness of acetabular cartilage after follow-up or treatment of DDH. This study aims to report the thickness of acetabular cartilage before and after treatment of DDH.

Materials and methods

In this prospective study, infants with clinical suspicion of DDH were enrolled in the pediatric outpatient service in our hospital from January 2022 to August 2023. The thickness of acetabular cartilage was measured in the standard coronal plane. Borderline hips (Graf IIa type) were monitored with monthly ultrasound examination until they were classified as normal hips (Graf I type), while dysplastic hips (Graf IIb type or worse) were treated with the Pavlik harness until they were also classified as normal hips in the final ultrasound examination.

Results

A total of 592 children [median age, 96 days (interquartile range, 70–142 days); 197 boys] were enrolled in the study. The thickness of acetabular cartilage in dysplastic hips (4.3 ± 1.6 mm) was greater than that in normal hips (3.0 ± .39 mm, P < 0.001) and borderline hips (3.1 ± .57 mm, P < 0.001). In borderline hips, the thickness of acetabular cartilage decreased from 3.1 ± .57 mm in the initial evaluation to 2.9 ± .53 mm in the final follow-up scan (P = 0.01). In dysplastic hips, the thickness of acetabular cartilage decreased from 4.3 ± 1.6 mm in the initial evaluation to 3.5 ± .51 mm after treatment (P = 0.003). The thickness of acetabular cartilage in dysplastic hips after treatment remained greater than that in normal hips (P < 0.0001).

Conclusion

The thickness of acetabular cartilage decreased after follow-up or treatment of DDH. Further research is required to determine whether cartilage that remain thicker in dysplastic hips than that in normal hips after treatment should be considered an early indicator of residual acetabular dysplasia.
Case Report: A “senior” with serpentine-like syndrome—treatment of combined brachyoesophagus, intrathoracic stomach and cervical rachischisis
Authors: Lohmann Judith , Freund Anna , Klein Tobias , Acero Daniel , Boemers Thomas
Published: September 2024

Serpentine-like syndrome, characterized by the combination of intrathoracic stomach, a notably short esophagus anomaly, splenic abnormalities, and cervical spine malformations, has been associated with a high mortality rate since its identification in 2008. This report presents the case of a remarkable patient who recently celebrated her fifth birthday, marking her as the oldest documented individual with this syndrome to date. Highlighting the significance of comprehensive evaluations for concurrent malformations, the report discusses potential treatment modalities and challenges inherent in managing patients with this intricate syndrome. A comprehensive review of previously published cases is provided, comparing surgical interventions, causes of death, and age at the time of demise. This report underscores the importance of ongoing research and collaborative efforts to optimize outcomes for individuals afflicted with serpentine-like syndrome.
Michael is better than Mehmet: exploring the perils of algorithmic biases and selective adherence to advice from automated decision support systems in hiring
Authors: Rosenthal-von der Pütten Astrid Marieke , Sach Alexandra
Published: September 2024

Introduction

Artificial intelligence algorithms are increasingly adopted as decisional aides in many contexts such as human resources, often with the promise of being fast, efficient, and even capable of overcoming biases of human decision-makers. Simultaneously, this promise of objectivity and the increasing supervisory role of humans may make it more likely for existing biases in algorithms to be overlooked, as humans are prone to over-rely on such automated systems. This study therefore aims to investigate such reliance on biased algorithmic advice in a hiring context.

Method

Simulating the algorithmic pre-selection of applicants we confronted participants with biased or non-biased recommendations in a 1 × 2 between-subjects online experiment (n = 260).

Results

The findings suggest that the algorithmic bias went unnoticed for about 60% of the participants in the bias condition when explicitly asking for this. However, overall individuals relied less on biased algorithms making more changes to the algorithmic scores. Reduced reliance on the algorithms led to the increased noticing of the bias. The biased recommendations did not lower general attitudes toward algorithms but only evaluations for this specific hiring algorithm, while explicitly noticing the bias affected both. Individuals with a more negative attitude toward decision subjects were more likely to not notice the bias.

Discussion

This study extends the literature by examining the interplay of (biased) human operators and biased algorithmic decision support systems to highlight the potential negative impacts of such automation for vulnerable and disadvantaged individuals.
Enhancing mental well-being of undergraduates: establishing cut-off values and analyzing substitutive effects of physical activity on depression regulation
Authors: Ma Yue , Gao Yulin , Yang Hui , Zhang Yu , Ku Yixuan
Published: September 2024

Objective

This study aimed to analyze the effects of physical activity (PA), sleep quality, and sedentary behavior on subthreshold depression (StD) among undergraduates.

Methods

This study included 834 undergraduates and assessed the impact of PA time, sleep quality, and sedentary behavior on depression. The receiver operating characteristic (ROC) analysis was performed to determine cut-off values for StD risk, while the isochronous substitution analysis was performed to evaluate the effects of different activities on depression regulation.

Results

Gender, age, and academic grade had no significant influence on depression levels among undergraduates (p > 0.05). However, students engaging in sedentary behavior for more than 12.1 h per day or with a Pittsburgh Sleep Quality Index score above 3.5 were at an increased risk of subclinical depression. Additionally, the isochronous substitution of light-intensity physical activity for other activities (sleep, sedentary behavior, moderate and vigorous intensity physical activity) showed statistically significant effects (p < 0.05) in both 5-min and 10-min substitution models, demonstrating a positive effect on alleviating depression.

Conclusion

The findings indicate that specific lifestyle factors, particularly high levels of sedentary behavior and poor sleep quality, are crucial determinants of subclinical depression among undergraduates, independent of demographic variables such as gender, age, and academic grade. Notably, light-intensity PA plays a key role in StD regulation, as substituting it with more intense physical activities or improving sleep quality substantially reduces depression scores. Furthermore, the benefits such substitution became more pronounced with the increase in duration of the activity.
Assessments scales for the evaluation of health-related quality of life in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy: a systematic review
Authors: Maiuolo Maria Lucia , Giorgini Roberto , Vaccaro Maria Grazia , Facchin Alessio , Quattrone Andrea , Quattrone Aldo
Published: September 2024

Background

The concept of wellbeing is expansive and intricate, making it challenging to define precisely. Similarly, the instruments employed to assess wellbeing are complex and multifaceted. Therefore, it is more appropriate to refer to the notion of wellbeing as Health-Related Quality of Life (HRQoL), which is the central focus of many measures used to assess the feeling of wellbeing. This review aimed to identify the tools most commonly used to evaluate HRQoL in individuals with Parkinsonism—a group of movement disorders that negatively impact the quality of life due to the intricate interplay of symptoms, socio-demographic characteristics, and psychological factors. The main aim was to assess the psychometric properties of these measures in terms of validity and reliability.

Methods

A literature review was conducted, focusing on research related to the assessment of HRQoL in connection to symptoms of Parkinsonism. This review included all studies that examined HRQoL using evaluation scales, exams, or self-reported questionnaires. The literature review was conducted using the databases Scopus and Web of Science and the search engine PubMed to identify studies published between 1996 and 2023. Only records that assessed HRQoL in individuals with Parkinson's disease and Parkinsonism were selected for evaluation.

Results

A total of 393 records were examined, and eight tools were identified as the most frequently used in the evaluation of HRQoL.

Discussion

The results show a significant gap in knowledge regarding the latent structure and measurement invariance of HRQoL measurements, which may have a significant influence on the interpretation of test outcomes. Moreover, there is a lack of clear divergent validity between HRQoL assessments and other tests used as predictors of HRQoL. This could represent a significant limitation, affecting the construct and criterion validity of HRQoL measures.
Effectiveness of group-based psycho-education on preventing postpartum depression among pregnant women by primary healthcare provider in primary healthcare institution: a cluster-randomized controlled trial
Authors: Tessema Marta , Abera Muluemebet , Birhanu Zewdie
Published: September 2024

Background

In Ethiopia, one in five mothers suffers from postpartum depression, which needs to be prevented through interventions. According to the World Health Organization, maternal healthcare providers have a unique opportunity to provide psychosocial interventions to prevent the damaging effects of perinatal depression. Hence, this study assessed the effectiveness of prenatal group-based psycho-education in preventing postpartum depression (PPD) in primary healthcare units.

Methods

We conducted a two-arm cluster-randomized controlled trial, enrolling 550 pregnant women at 12–20 weeks of gestation with a normal score (0–4) and a mild score (5–9) on the Patient Health Questionnaire-9 (PHQ-9). The study utilized simple randomization techniques to assign clusters between arms in a 1:1 ratio. The data was collected through face-to-face interviews conducted at 12-20 weeks of gestation and 6 weeks postpartum. The intervention group received usual care plus five prenatal group-based psycho-education (PGBPE) classes, while the control group received only usual care. The PPD status between arms was compared using the chi-square test of association. A mixed-effects multilevel logistic regression model was also used to examine the predictors of the outcome variables.

Results

The overall response rate at the end line was 92.9%. Thus, compared to that in controls, the PPD in the intervention clusters was considerably lower (20 (7.6%) vs. 74 (28.9%)), P = 0.001)/65% (AOR = 0.35, 95% CI = 0.13–0.99), although no difference was detected at baseline. Social support (AOR = 0.04, 95% CI = 0.01–0.15), partner emotional support (AOR = 0.24, 95% CI = 0.12–0.51), PPD literacy (AOR = 0.25, 95% CI = 0.11–0.62), and self-esteem (AOR = 0.22, 95% CI = 0.11–0.47) were more likely to protect mothers from PPD. On the contrary, domestic work (AOR = 9.75, 95% CI = 3.37–28.16), neonates with complications (AOR = 5.79, 95% CI = 2.04–16.45), and unhealthy coping (AOR = 2.39, 95% CI = 1.06–5.42) exposed mothers to PPD.

Conclusion

The implementation of a PGBPE in primary healthcare units (PHCUs) was effective at preventing PPD. Therefore, this intervention method has to be promoted and used in PHCUs to prevent PPD.

Clinical Trial Registration

[Pan African Clinical Trial Registry], identifier [PACTR 202203616584913].
General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases
Authors: Altintas Ozlem , MacArthur Michael R.
Published: September 2024

The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its role in health and disease states. In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer. Finally, we summarize the barriers to effectively targeting GCN2 for the treatment of disease and to promote a healthier aging process.
Electrocardiographic abnormalities and associated factors among HIV-infected adults on antiretroviral therapy
Authors: Befkadu Zewudu , Ibrahim Mohammed , Tadelle Amanuel , Tegene Elsah
Published: September 2024

Background

Individuals living with HIV are at increased risk of developing cardiovascular diseases. This heightened vulnerability is influenced by various factors, including the direct impact of HIV infection, the side effects of HIV medications, and a higher presence of traditional cardiovascular risk factors. Detecting and managing cardiovascular diseases early in HIV-infected individuals is crucial for their overall health and well-being. Electrocardiography, a simple and non-invasive test, can provide valuable information in this regard. However, there is currently no published data on the prevalence of electrocardiographic abnormalities and the associated factors among HIV-infected adults in Ethiopia.

Objectives

This study was aimed at assessing the prevalence of ECG abnormalities and associated factors among HIV-infected adults on antiretroviral therapy.

Methodology

A hospital-based comparative cross-sectional study was conducted at Mettu Karl Specialized Hospital (MKSH), southwest Ethiopia, among 96 HIV-infected patients and 96 HIV-negative control groups. A systematic random sampling technique was used to select HIV-infected respondents, and HIV-negative respondents were purposively recruited from caregivers. A face-to-face interview with a semi-structured and pretested questionnaire was conducted to collect the socio-demographic and behavioral characteristics of the study participants. Electrocardiography was done for all study participants using a 12-lead electrocardiograph, interpreted by a cardiologist, and classified according to the Minnesota Code classification system. The data were entered into Epi-Data version 4.6 and exported to SPSS version 25 for analysis. Finally, descriptive statistics, chi-square, independent t-test, bivariable, and multivariable logistic regression analyses were done at a 5% significance level.

Results

The study found that 49% of HIV-infected and 19.8% of HIV-negative participants had at least one ECG abnormality. The proportion of coded ST-segment abnormalities, T-wave abnormalities, longer QT interval, and sinus tachycardia was significantly higher in HIV-infected respondents than in HIV-negatives. Being a smoker [AOR = 3.7, 95%CI: 1.03–13.6], being on Protease inhibitors [AOR = 3.6, 95%CI: 1.02–13.1] and having CD4 less than 350 cells/mm3 [AOR = 3.2, 95%CI: 1.22–8.49] were significantly associated with ECG abnormalities among HIV-infected respondents.

Conclusion

Compared to HIV-negative participants, HIV-infected patients had a significantly higher prevalence of ECG abnormalities. Screening for ECG abnormalities is needed for the early detection of cardiac abnormalities and the reduction of future complications.
Perspectives on healthcare decarbonization through plant-rich dietary shifts: cases from the US, Austria and Taiwan
Authors: Wyma Nanine , Niesing Christi
Published: September 2024

The reduction of meat consumption in health systems is a high-impact pathway for healthcare decarbonization. Effects including changes in greenhouse gas emissions are rarely calculated following interventions, such as the implementation of plant-forward menus in hospitals, and the results of these changes are rarely published in peer-reviewed literature. In this perspective, we discuss the decarbonization outcomes of plant-rich dietary shifts across five health systems worldwide, gathered from peer-reviewed and gray literature. In each case, the implementation of a plant-rich approach reduced food-related greenhouse gas emissions. Health co-benefits are also commonly reported. The measurement of greenhouse gas emissions of plant-rich dietary shifts in future health system interventions is encouraged, with the results published in peer-reviewed journals.
From pollution to resource: advancing swine waste treatment in the USA
Authors: Aneja Viney P. , Longest Ryke , Vanotti Matias B. , Szogi Ariel A. , Reddy Gudigopuram B.
Published: September 2024

Concentrated animal feeding operations (CAFOs) have led to environmental challenges, specifically waste management. Swine CAFOs generate large amounts of waste, requiring proper treatment to avoid air and water pollution. Conventional waste management technologies, such as lagoon and spray field systems, do not prevent air and water pollution impacts. Research for the past few decades led to recommendations for waste treatment technologies superior to lagoons and spray fields. Private environmental sustainability initiatives focused on reducing greenhouse gas emissions in the food supply chain have implemented biogas digester projects for capturing methane in covered swine lagoons to reduce greenhouse gas emissions. However, research indicates that methane capture alone does not solve the broader pollution issues associated with lagoon and spray field systems still in use at these CAFOs to dispose of digested effluents. The Environmentally Superior Technologies (EST) initiative in North Carolina set public standards to eliminate waste discharge, reduce atmospheric emissions, and control odors and pathogens. Research has confirmed that technologies coupling solids separation with water treatments to remove volatile organic carbon, pathogens, and reactive forms of nitrogen can meet EST standards. A designated EST—the Super Soil System—substantially reduced odor by 99.9%; pathogens by 99.99%, nutrients (phosphorus and nitrogen) by >90%, and heavy metals (cooper and zinc) by 99%. The ammonia emissions were reduced by 94.4% for the warm and 99.0% for the cool season with respect to a conventional lagoon system. Corresponding greenhouse gas emission reductions were 96.7%. Components of designated EST can be applied to retrofit covered lagoons and anaerobic digestion systems with significant environmental benefits. Recommendations are proposed, based on the collective experience with EST and current trends in animal production concentration, for environmentally safe technologies to handle excess manure produced in the USA.
Comparative study of acute kidney injury in pararenal aortic aneurysm: open surgical versus endovascular repair
Authors: Sultan Sherif , Acharya Yogesh , Tawfick Wael , Wijns William , Soliman Osama
Published: September 2024

Background

Pararenal abdominal aortic aneurysms (PR-AAA), constituting around 15%-20% of AAA patients, are defined as having no neck between the aneurysm and the renal arteries. Due to an insufficient sealing zone, open surgical repair (OSR) is the gold standard, while EVAR is reserved for those unfit for surgery. Renal outcomes disturb long-term survival, and they have massive socioeconomic and quality of life implications, especially if patients require dialysis.

Methods

This study aims to elucidate any difference between EVAR and OSR of PR-AAA, excluding suprarenal aneurysms, with specific emphasis on renal dysfunction over the short and long term. An existing database of PR-AAA between 2002 and 2023 was used to glean information regarding the therapeutic option used. Renal events were defined by the RIFLE criteria. Out of 1,563 aortic interventions, we identified 179 PR-AAA, of which 99 high-risk patients had an aortic neck of less than 10 mm with complete follow-up. We excluded patients with fenestrated EVAR (FEVAR), branched EVAR (BEVAR), or chimney EVAR (Ch-EVAR) and any patients requiring visceral artery reimplantation.

Results

In total, 63 patients underwent EVAR, and 36 required OSR. 17.46% of patients who underwent EVAR experienced acute kidney injury (AKI) compared with 36.11% of the OSR group (P = 0.037). The mean post-op creatinine for OSR was 109.88 µmol/L, and for EVAR was 127.06 µmol/L (P = 0.192). The mean difference between long-term (9–12 years) creatinine values in OSR was 14.29 µmol/L (P = 0.191), and the mean difference for EVAR was 25.05 µmol/L (P = 0.024). Furthermore, 27.8% of OSR patients who underwent Left Renal Vein Division and Ligation (LRVDL) experienced an AKI, while 50% who did not undergo LRVDL experienced an AKI (P = 0.382). Thirty-day morbidity in the EVAR group (20.97%) was significantly lower than in the OSR group (42.62%) (P = 0.022). Moreover, 3.17% in EVAR group and 7.14% in OSR group had aneurysm-related mortality (P = 0.584).

Conclusion

The rate of renal events for OSR is higher, while the rate of endovascular renal events was lower. Our study shows that PR-AAA undergoing OSR may benefit from endovascular repair.
Low-Volume Ex Situ Lung Perfusion System for Single Lung Application in a Small Animal Model Enables Optimal Compliance With “Reduction” in 3R Principles of Animal Research
Authors: Katsirntaki K. , Hagner S. , Werlein C. , Braubach P. , Jonigk D. , Adam D. , Hidaji H. , Kühn C. , Falk C. S. , Ruhparwar A. , Wiegmann B.
Published: September 2024

Graphical Abstract

After lung procurement from Lewis and Fischer 344 rats, the left lung was perfused ex situ, while the right lung was kept statically cold as a control. In addition to thermal imaging, lung histology and analyses of lung weight, key perfusion parameters, blood gas analysis, cytokines, and colloidal oncotic pressure were performed. Figure was created with BioRender.com.
Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases
Authors: Shahid Aqsa , Bhatia Madhav
Published: September 2024

In recent years, research has unveiled the significant role of hydrogen sulfide (H2S) in many physiological and pathological processes. The role of endogenous H2S, H2S donors, and inhibitors has been the subject of studies that have aimed to investigate this intriguing molecule. The mechanisms by which H2S contributes to different diseases, including inflammatory conditions, cardiovascular disease, viral infections, and neurological disorders, are complex. Despite noteworthy progress, several questions remain unanswered. H2S donors and inhibitors have shown significant therapeutic potential for various diseases. This review summarizes our current understanding of H2S-based therapeutics in inflammatory conditions, cardiovascular diseases, viral infections, and neurological disorders.
Mechanical and Microstructural Characterization of AISI 316L Stainless Steel Superficially Modified by Solid Nitriding Technique
Authors: Guardian-Tapia Rene , Rosales-Cadena Isai , Roman-Zubillaga Jose Luis , Gonzaga-Segura Sergio Ruben
Published: September 2024

AISI 316L austenitic stainless steel superficially modified by the solid nitriding technique was investigated at different nitriding times (2, 4, 6, 8, 12 and 24 h) and at 450 °C. The microstructural characterization was conducted using scanning electron microscopy (SEM) analysis and X-ray diffraction analyses, finding the presence of Fe2–3N, Fe4N and Cr2N, among others. The mechanical behavior of the modified surfaces was carried out by developing hardness profiles and relating it with the nitride layer thickness evaluated using scanning electron microscopy (SEM), obtaining layers up to 70 µm wide. The nitrogen diffusion produced species above and below the surface sample with a transformation from the austenitic phase to an expanded austenite (γN) phase, which is responsible for producing an increase in hardness of up to 1200 HV in the samples treated at 24 h, which is four times higher than the untreated steels. Wear evaluations of the obtained layers were performed using a pin-on-disk system under zero lubrication, indicating that the samples with 12 and 24 h of treatment present the best wear resistance promoted by an oxidative–adhesive mechanism. The obtained results are positively comparable with those of the ion nitriding technique but with a lower implementation cost.
Development of Statistical Downscaling Model Based on Volterra Series Realization, Principal Components, Climate Classification, and Ridge Regression
Authors: Singh Pooja , Shamseldin Asaad Y. , Melville Bruce W. , Wotherspoon Liam
Published: September 2024

This paper applied the fuzzy function approach, combined with the ridge regression model, to produce daily rainfall projections from large-scale climate variables. This study developed a statistical downscaling model based on principal components, c-means fuzzy clustering, Volterra series, and ridge regression. The model is known, hereafter as SDC2R2. In the developed downscaling model, the use of ridge regression, instead of multiple linear regression, is proposed to downscale daily rainfall with wide range (WR) predictors. The WR predictors were applied to sufficiently incorporate climate change signals. The developed model also captured the non-linear interactions of the climate variables by applying the transformation of Volterra series realization over WR predictors. This transformation was performed by applying principal components as orthogonal filters. Further, these principal components were clustered by using c-means clustering and non-linear transformations were applied on these membership functions, to improve the prediction ability of the model. The reanalysis of climate data from the National Centres for Environmental Prediction (NCEP) was used to develop the model and was validated by using the Global Climate Model (GCM) for four locations in the Manawatu River basin. The developed model was used to obtain future daily rainfall projections from three Representative Concentrative Pathways (RCP 2.6, RCP 4.5, and RCP 8.5) scenarios from the Canadian Earth System Model (CanESM2) GCM. The performance of the model was compared with a widely used statistical downscaling model (SDSM). It was observed that the model performed better than SDSM in downscaling rainfall on a daily basis. Every scenario indicated that there is a probability of obtaining high future rainfall frequency. The results of this study provide valuable information for decision-makers since climate change may potentially impact the Manawatu basin.
Sustainable Finance Meets FinTech: Amplifying Green Credit’s Benefits for Banks
Authors: Li Zhitao , Chen Ping
Published: September 2024

In recent years, green credit has significantly supported the development of the sustainable economy. However, the existing literature presents differing views on the impact of green credit on bank performance, which is crucial for the sustainability of green credit business. Meanwhile, FinTech is comprehensively empowering green credit business. This paper investigates whether FinTech influences the effect of green credit on bank performance. Based on an analysis of data from 127 Chinese commercial banks from 2007 to 2022, we find that green credit significantly enhances bank performance, and FinTech further amplifies this positive effect. This finding partially explains the conflicting views in the existing literature, as the impact of green credit on bank performance varies under different levels of FinTech. We believe that FinTech exerts its influence through three mechanisms: cost reduction, reputation enhancement, and risk mitigation. Heterogeneity analysis reveals that the impact of FinTech is more pronounced in city commercial banks, in samples with better green credit development, and during banking industry downturns. Finally, we recommend that banks actively develop FinTech and apply it to green credit businesses to maximize the positive effects of green credit. Simultaneously, regulators and governments should provide necessary support for banks.
Cultural Capital. First part
Authors:   Standardisation University, St. Petersburg, Shestakov V.A.
Published: September 2024

Article is written in concern to the notion of Cultural capital. Author elaborates on its otherwise convoluted definitions that deviate from the substantial notion of a capital as a mean of value production. Author’s reasoning in the article relies on self-established definition of cultural values that places a division between basis and imaginary values and then formulates grade system for types of cultural values depending on their acknowledgment in major societal groups. Cultural values require proper audit in the same way as all other values, which is covered in the second part of the article.
Consequences of the Expiration of an Employment Contract: Theory and Practice
Authors:   ember of the Scientific Advisory Council at the Prosecutor General's Office of the Russian Federation, retired judge of the Moscow City Court, Mironov V.I. , Barbashova T.P. ,   Department of Civil Law Disciplines of the Faculty of Law of the Russian State University of Oil and Gas (NRU) named after I.M. Gubkin
Published: September 2024

On the example of judicial practice, the theoretical issues of the implementation of labor law norms on a fixed-term employment contract are considered.