bluuebunny/crossref_metadata_2025 huggingface dataset:
Membranous Glomerulonephritis: Role of Retinol-Binding Protein in Monitoring and Prognostication
Authors: Maifata Sadiq Muazu , Abd Ghani Fauzah , Hod Rafidah , Zakaria Nor Fadhlina
Published: August 2021

Initially, retinol-binding protein (RBP), was thought to be a biomarker for proximal convoluted tubule dysfunction could be important in chronic kidney diseases (CKD). Membranous glomerulonephritis (MGN) is an important cause of CKD and end-stage renal disease (ESRD). Therefore, monitoring MGN patients using urinary RBP is important in effective treatment decision making and prognostication of MGN patients. Enzyme-linked immunosorbent assay (ELISA) technique was used to detect the RBP in the urine samples of 69 MGN patients comprising 47 primary and 22 secondary MGN, at the end of the follow-up period. The test for the urinary biomarker gave the following results: urinary RBP was detected in 27 (39.1%) and 6 (8.7%) of the primary and secondary MGN patients, respectively. The correlation analysis demonstrated a significant relationship between urinary RBP and renal function test parameters, in addition to a logistic regression analysis that proved urinary RBP as a prognostic non-invasive biomarker for primary MGN. Therefore, urinary RBP could be employed to monitor and provide effective prognosis and early treatment decisions in primary MGN.
A Bayesian Analysis of the Inversion of the SARS-COV-2 Case Rate in the Countries of the 2020 European Football Championship
Authors: Casini Luca , Roccetti Marco
Published: August 2021

While Europe was beginning to deal with the resurgence of COVID-19 due to the Delta variant, the European football championship took place, June 11 - July 11, 2021. We studied the inversion in the decrease/increase rate of new SARS-COV-2 infections in the countries of the tournament, investigating the hypothesis of an association. Using a Bayesian piecewise regression with a Poisson Generalized Linear Model, we looked for a changepoint in the timeseries of the new SARS-COV-2 cases of each country, expecting it to appear within four weeks since the date of their first match. The two slopes, before and after the changepoint, were used to discuss the reversal from a decreasing to an increasing rate of the infections. 17 out of 22 countries (77%) have had a changepoint 14.97 days after their first match [95% CI 12.29 to 17.47]. For all those 17 countries, the changepoint coincides with an inversion from a decreasing to an increasing rate of the infections. Before the changepoint, the new cases were decreasing, halving on average every 18.07 days [95% CI 11.81 to 29.42]. After the changepoint, the cases begin to increase, doubling every 29.10 days [95% CI 14.12 to 49.78]. This inversion in the SARS-COV-2 case rate, happened during the tournament, provides evidence in favor of a relationship.
Epitranscriptomic Approach: To Improve the Efficacy of ICB Therapy by Co-targeting Intracellular Checkpoint CISH
Authors: Kumar Sunil , Sarthi Parth , Mani Indra , Ashraf Muhammad Umer , Kang Myeong-Ho , Kumar Vishal , Bae Yong-Soo
Published: August 2021

Cellular immunotherapy has recently emerged as a fourth pillar in cancer treatment co-joining surgery, chemotherapy and radiotherapy. Where, the discovery of immune checkpoint blockage or inhibition (ICB/ICI), anti-PD-1/PD-L1 and anti-CTLA4-based, therapy has revolutionized the class of cancer treatment at a different level. However, still some cancer patient escape this immune surveillance mechanism and become resistant to ICB-therapy. Therefore, a more advanced or an alternative treatment is required instantly. Despite the functional importance of epitranscriptomics in diverse clinico-biological practices, its role in improving the efficacy of ICB therapeutics has been limited. Consequently, our study encapsulates the evidences, as a possible strategy, to improve the efficacy of ICB-therapy by co-targeting molecular checkpoints especially N6A-modification machineries which could be reformed into RNA modifying drugs (RMD). Here, we have explained the mechanism of individual RNA-modifiers (editor/writer, eraser/remover and effector/reader) in overcoming the issues associated with high-dose antibody toxicities and drug-resistance. Moreover, we have shed light on the importance of suppressor of cytokine signalling (SOCS/CISH) and microRNAs in improving the efficacy of ICB-therapy, with brief insight on the current monoclonal antibodies undergoing clinical trials or already approved against several solid tumor and metastatic cancers. We anticipate our investigation will encourage researchers and clinicians to further strengthen the efficacy of ICB-therapeutics by considering the importance of epitranscriptomics as a personalized medicine.
Intracellular Ion Changes Induced by the Exposure to Beta-Amyloid Can Be Explained by the Formation of Channels in the Lysosomal Membranes
Authors: Zaretsky Dmitry V , Zaretskaia Maria V
Published: August 2021

In this manuscript, we reassess the data on beta-amyloid-induced changes of intracellular ions concentrations published previously by Abramov et al. (2003, 2004). Their observations made using high-resolution confocal microscopy with fast temporal resolution of images formed by fluorescent ion-sensitive fluorescent probes in living cells represent an unequivocal support for the amyloid channel theory. However, closer look reveals multiple facts which cannot be explained by channel formation in plasma membrane. Recently proposed amyloid degradation toxicity hypothesis provides the interpretation to these facts by considering that channels are formed in the lysosomal membranes.
CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study
Authors: Ciarambino Tiziana , pietrantonio filomena , Rotunno Sara , Fiorentini Alessandra , Cipriani Rosalba , Campagna Giuseppe , Straface Giuseppe , Pistella Eleonora , giordano mauro , Rosiello Francesco , Giannico Orazio Valerio , lorenzi federica
Published: August 2021

Background: from December 2019 and the spreading of syndemics, a lot of medical centers reg-istered data about their patients. In Italy, the most relevant quantity of patients was hospitalized in internal medicine wards. Methods: In this observational, retrospective cross-sectional study, all data of the COVID-19 patients, admitted Latio hospitals, from March 01 to December 31, 2020, were collected and their Epidemiological data, demographics, signs and symptoms on admission, comorbidities, laboratory findings, chest radiography and CT findings, treatment received and mortality rate were analyzed by gender to find any differences of gravity of disease. Clinician details were registered on database (one for every hospital). Cost analysis was performed by length of stay and antiviral drugs use, using point of view of Italian Healthcare System. Results: 2256 patients with mean age of 71.01 ± 28.02 years were included. For men, frequency of hyper-tension, COPD, use of oxygen therapy, Tocilizumab were significantly higher and epidemiolog-ical link was related to rehabilitation ward and community. The gender difference about hospi-talization was one day more for man. No strong significant difference by gender in the death rate was observed. Considering antiviral drugs and hospitalization, a man costs €1000 more than woman. Conclusions: In male patients, hypertension and COPD were observed more frequently and the epidemiological link was related to rehabilitation ward and community. In female sub-jects, the epidemiological link was related to Hospital and we observed significantly higher atypical chest-X ray. Tocilizumab, oxygen therapy and antiviral drugs were prescribed more in male subjects. No differences by gender we report in other treatments and outcomes. Future studies should be analyzed to get a more comprehensive understanding of COVID-19 by gender.
Examining Virtual Reference Services in Academic Libraries in the Middle East
Authors: Abul Zahraa , Alkandari Aysha , Alajmi Bibi
Published: August 2021

This research focuses on examining the availability of Virtual Reference Services in academic libraries in the Middle East. Virtual Reference Services could be provided in several ways, for example: by telephone, email, live chat, video conferencing, texting, and recently using social media applications like Twitter. This research will explore the presence of Virtual Reference Services in Middle Eastern academic libraries, and the ways in which they are presented. 55 academic libraries’ websites have been examined with a checklist that includes: the nature of reference services available, the time it took to locate the Virtual Reference Services, the text included in the link to describe the services, and the number of links navigated on the webpage to find the reference services. The main objective of this research is to examine the use of Virtual Reference Services in Middle Eastern university libraries and to increase the awareness of the libraries’ resources and services. Findings of this study showed that live chat as a Virtual Reference Service in the Middle East is not very prevalent. In addition, it was found that email as a means of virtual communication is used most commonly by the academic libraries that provided Virtual Reference Services.
Sustainability in Residential High-Rise Building Using Knowledge Management of Critical Success Technique
Authors: Chonratana Yossakorn , Chatpattananan Vuttichai
Published: August 2021

Sustainability is very important in business. The residential high-rise building all firms wanted to successful and sustainability in business. There is need the construction to completed low time, low cost and high quality in construction work. Therefore, real estate developers must find various strategies to use in construction projects to achieve goals and success of the firm. The purpose of this study was to indicate the very importance of knowledge management can lead to sustainability in business. Analyze 14 critical success to sustainability in residential high-rise building projects, collected questions from literature review, and survey in deep interview senior managers of 15 projects real estate development firms listed on the stock market of Thailand. Budget building more than 1000 million baht per project. From conceptual frame work five foundations integrated to knowledge management of critical success (KMITL PROCESS) used made tool survey in deep interview the critical success to sustainability in residential high-rise building project from project managers. Used IBM SPSS evaluated the critical success to sustainability. Found was one very important of critical success to sustainability, which was quality of products x̄ = 4.83. All 14 critical success to sustainability was found can applied made the knowledge management of critical success to sustainability in residential high-rise building project in firm. Especially in the field of construction managements project can used improve of all construction projects.
РАСПРОСТРАНЕНИЕ ВАРИАНТОВ ВИРУСА SARS-COV-2, ВЫЗЫВАЮЩИХ ОЗАБОЧЕННОСТЬ (VOC) И ИНТЕРЕС (VOI) НА ОСНОВЕ КОЛИЧЕСТВА ИХ ГЕНОМОВ, ДЕПОНИРОВАННЫХ В БАЗУ ДАННЫХ GISAID ЗА НЕДЕЛЮ с 31.07. по 06.08.2021 г.
Authors: Чумачкова Елена , Дмитриева Людмила , Краснов Ярослав , Осина Наталия , Сафронов Валентин , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: August 2021

В обзоре представлен анализ геновариантов вируса SARS-CoV-2, вызывающих озабоченность (VOC) и интерес (VOI) на основе их геномов в базе GISAID за неделю с 31.07.2021 г. по 06.08.2021 г.
The Awareness of Sharia Financial Literacy in The Quarterlife Crisis Phase
Authors: Rahmatia Alfina
Published: August 2021

Nowadays, there are enormous challenges toward this era, especially the young generation between 20 and first 30 years old who will face quarterlife crisis phase in which one of the causes is literate or not literate to finance. The grand objective of this research is to analyze gender, income per month, and marital status toward the awareness level to sharia financial literacy in the quarterlife crisis phase for IAIN Palangka Raya Alumni in 2010-2015. Primary data applied in this study are compiled from questionnaires and interviews with mixed methods. This research uses multiple regression with SPSS application, while the interview data uses descriptive analysis. The result reveals that gender and income per month have no significant influence on the awareness level of sharia financial literacy, but marital status has a significant influence on the awareness level of sharia financial literacy for IAIN Palangka Raya Alumni on 2010-2015.
The Role Of Women In Improving The Family Economy
Authors: Zunaidi Arif , Maghfiroh Facrial Lailatul
Published: August 2021

The purpose of this study was to determine the role of women in improving the family economy, especially women who work as shallot retail workers. This study uses a qualitative descriptive method, namely formulating a data obtained from words or sentences separated according to the intended category to obtain conclusions. The results of this study conclude that women have a role in helping the family economy. The main reasons why women have to work outside rather than domestic work are economic reasons and self-actualization to help their husbands. The economic demands of the family caused these women to choose to become laborers. Helping husband's finances, to pay needs, and pay arisan.
Sharia Fintech As An Instrument Of National Economic Recovery Amid The Covid-19 Pandemic
Authors: Istifadhoh Nurul , A’yun Inarotul , Mufidhoh Hafidhotul
Published: August 2021

The focus of this research is to uncover the existence of sharia fintech which is considered able to accelerate the process of accelerating economic recovery due to pandemics that have an impact on the slowdown of the national scale economy.This research was conducted using an in-depth literature study with qualitative descriptive analysis techniques approach. The data collection method used is the library method. The literature used as a reference is scientific articles, mass media articles, textbooks, and other online literature searches that correspond to this research.The results of the study show fintech contributes positively to the national economic recovery and the increase in state revenues during the pandemic. This can be improved by supporting strengthening government regulations for inclusive and sustainable fintech growth so that fintech has the potential to be a triggering factor for the digital financial services industry in Indonesia.
The halal fashion trends for hijabi community: Ideology and consumption
Authors: Susilawati Nilda , Yarmunida Miti , Elwardah Khairiah
Published: August 2021

The research is based on a large enough market potential for the development of the halal fashion industry in Indonesia. The hijab fashion trend is a production target that continues to develop with various technologies and innovations, which encourage the consumption of community groups to use hijab fashion to continue to increase. The study was conducted to determine the purpose of the hijab community in using halal hijab fashion as part of their identity in demonstrating the existence of the hijab group through the ideological and consumption approaches. Qualitative analysis is carried out to determine the ideological emphasis and consumption of the hijab community through open interviews to obtain a clear picture of the social situation. The results show that religious beliefs are the main basis in encouraging the use of hijab and necessity factors.
PERSEPSI KESIAPAN KERJA MAHASISWA SETELAH MELAKSANAKAN KERJA PRAKTIK INDUSTRI (KPI) PADA PRODI PENDIDIKAN INFORMATIKA
Authors: Wijaya Etistika Yuni , Aini Nuru
Published: August 2021

Penelitian ini bertujuan untuk mengetahui kesiapan ekrja mahasiswa prodi pendidikan informatika angkatan 2017 yang telah melaksanakan Kerja Praktik Industri (KPI). Penelitian ini merupakan penelitian deskriptif kuantitatif yang dilakukan di Prodi Pendidikan Informatika. Populasi yang digunakan adalah 49 mahasiswa Prodi Pendidikan Informatika angkatan 2017. Teknik pengumpulan data menggunakan angket tertutup (kuesioner). Teknik analisis data yang digunakan adalah deksriptif. Hasil penelitian diketahui bahwa  persepsi  kesiapan kerja mahasiswa setelah melaksanakan Kerja Praktik Industri (KPI) pada Prodi Pendidikan Informatika dijabarkan menjadi  Sembilan indikator, yaitu: (a) menguasai teori dan praktik; (b) memiliki Kematangan kompetensi, fisik, mental, pengalaman, informasi dan kemampuan untuk bekerja; (c) memiliki pertimbangan logis dan obyektif; (d) mampu menyelesaikan tugas; (e) mengetahui wawasan tentang dunia kerja; (f) mampu mengoperasikan suatu alat sesuai dengan SOP; (g) mampu menyesuaikan diri dengan lingkungan sekitar dan mudah bergaul dengan rekan kerja; (h) mampu bersikap kritis; dan (i) mampu menerima tanggung jawab atas pekerjaanya mempunyai mena 31,3 berada dalam ketegori baik. Indikator tertinggi adalah terletak pada indikator 7 yaitu mahasiswa mampu untuk menyesuaikan diri dengan lingkungan sekitar dan mudah bergaul dengan rekan kerja.
Kedaulatan Rakyat Dalam Konteks Demokrasi Di Indonesia
Authors: Qoroni Waisol , Winarwati Indien
Published: August 2021

ABSTRAK Kedaulatan rakyat yang di atur dalam Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 pasal 1 ayat (2). Dalam skripsi ini membahas tentang implementasi kedaulatan rakyat yang diatur didalam UUD dalam konteks demokrasi, yang dimaksud dengan demokrasi ini yaitu berasal dari kata yunani yaitu “demos” dan “kratos” demos artinya rakyat sedangkan kratos artinya kekuasaan yang mana dapat diartikan bahwa demokrasi kekuasaannya berada ditangan rakyat. Tetapi pada masa ini tidaklah mungkin seluruh rakyat yang memegang kekuasaan atas negara maka yang dilaksanakan oleh negara adalah demokrasi dengan sistem perwakilan. Di Indonesia kedaulatan rakyat berdasarkan UUD NRI Tahun 1945 pasal 1 ayar (2) yang dilaksanakan oleh DPR melalui kinerja DPR yaitu seperti Focus Group Discussion (FGD), parlemen kampus dan parlemen remaja diilihat dari kinerja DPR yang melaksanakan kedaulatan rakyat belum maksimal karena belum merata dan masyarakat banyak yang tidak mengetahui karena DPR hanya mengadakan diskusi dan meminta pendapat dari masyarakat kampus yang dianggap ahli, dan juga dalam bentu pembentukan perundang-undangan bahwasannya DPR mempunyai kewenangan untuk membentuk undang-undang sedangkan masyarakat juga dapat perbartisipasi dalam pembentukan peraturan perundang-undangan dengan cara-cara yang sudah ditentukan dan juga masyarakat juga dapat berpartisipasi dengan tiga metode yaitu metode Ante Legislative, Legislative dan Post Legislativ.Kata kunci : Kedaulatan rakyat, DPR, Undang-undang Dasar NRI Tahun 1945.
Perlindungan Hukum Terhadap Penyalahgunaan Akun Dalam Transaksi Elektronik Melalui Traveloka
Authors: Putra Ferdy Arliyanda , Nugroho Lucky Dafira
Published: August 2021

ABSTRAK Model perdagangan saat ini mulai bergeser pada perdagangan melalui sistem elektronik yang biasanya disebut marketplace. Sebelum melakukan transaksi elektronik melalui sistem elektronik biasanya diminta oleh sistem untuk membuat akun atau yang biasa disebut sebagai identitas konsumen. Akun tersebut berisikan identitas, user, dan password untuk dapat melakukan transaksi. Dalam perkembangannya, marketplace tersebut menyediakan sistem paylater yang memudahkan pemilik akun/konsumen untuk membayar tagihan dikemudian hari atau dengan kata lain utang kepada marketplace tersebut. Ada suatu kasus dimana salah satu markeplace, traveloka, disalahgunakan oleh pihak ketiga yang tidak bertanggung jawab yaitu untuk membeli tiket dan menjual tiket dengan menggunakan akun milik orang lain. Dari permasalahn tersebut hendak mencari penyelesaian hukum dengan upaya melindungi konsumen/pemilik akun dan pemulihan kerugian pemilik akun/konsumen tersebut. Untuk menjawab permasalahan tersebut menggunakan metode penelitian hukum. Adapun hasil penelitian yang telah dilakukan adalah perlindungan hukum bagi pemilik akun adalah perlindungan hukum internal dan eksternal. Perlindungan hukum internal termaktub dalam syarat dan ketentuan yang tercantum dalam aplikasi traveloka yang dapat dijadikan dasar untuk meminta ganti rugi apabila ada penyalhgunaan akun. Selain itu, perlindungan hukum eksternal diatur dalam Pasal 31 PP 71/2019 tentang Penyelenggaraan Sistem dan Transaksi Elektronik dan Pasal 37 POJK Nomor 77/POJK.01/2016 Tentang Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi. Upaya pemulihan krugian dapa dilakukan melalui gugatan PMH ke pengadilan negeri. Kata Kunci : perlindungan hukum, penyalahgunaan, akun, transaksi, elektronik
Manajemen Modal Kerja, Piutang, Dan Profiabilitas Dalam Masa Pandemi Covid-19 (Studi Pada PT. Benny Surabaya Trans)
Authors: Musdalifah Musdalifah , Purnamawati Purnamawati
Published: August 2021

The purpose of this study wa to determine the conditions of working capital, accpunts receivable, and profitability management at PT. Benny Surabaya Trans. The subjects used in this study were companies engaged in shipping services throughout Indonesia, namely PT. Benny Surabaya Trans. The object of this research is to analyze working capital management, accounts receivable management, profitability management during the Covid-19 pandemic. The type of research is descriptive quantitative. The calculation of wprking capital turonover accurs as a result of instability due to descreasing current liabilities so that it is not effective for working capital. The receivable turnover calculation id accordance with the company standard which is set twice a mont for receivables turnover so that it is effective and runs well. The calculation of return on assets is volatile due to increases and decreases in net income which are not considered by rhe manager so that it is ineffective, which means that profitability management is also closely relates to working capital management and receivables management.
Kriteria Penulisan Jurnal Personifikasi Program Studi Psikologi
Authors: Personifikasi Redaksi
Published: August 2021

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THE LEGAL ENTITY OF BAITUL MAAL WAT TAMWIL (BMT) AS A MICRO FINANCIAL INSTITUTION IN INDONESIA
Authors: Rijal Moh Syaifur
Published: August 2021

The purpose of this study is to analyze the legal status and accountability of Baitul Maal Wat Tamwil (BMT) as a financial institution in Indonesia, because so far BMT has two main functions,  the first, Baitul Maal as a non-profit institution that distributes zakat, infaq and alms, and the second, Baitul Tamwil is an institution whose function is to collect and to distribute commercial funds. This research uses normative research using a statutory approach and a conceptual approach. The results of this study indicate that the legal status of BMTs so far can only be established with the status of a cooperative or limited liability company. It refers to the characteristics possessed by BMT itself. The form of BMT accountability follows the form of liability that exists in the form of a BMT legal entity, if the loss is caused by the management or organs, the management or organs are jointly and severally responsible, but otherwise if the management or organs can prove then the management or organs are not jointly responsible for the losses incurred by BMT.
“JAYUS” Meja Payung Solar Cell
Authors: Sulistiyanto Sulistiyanto , Aperilian Damara Tidar Pangestu , Mustaqim Abdul , Devyce Achmad , Adawiyah Robiatul
Published: August 2021

Kebutuhan untuk isi ulang atau charger peralatan elektronik di tempat umum sangat diperlukan oleh masyarakat, terutama di tempat terbuka atau outdoor. Model yang tepat untuk dipakai sebagai tempat charger umum di area outdoor yang sesuai yaitu seperti payung yang di lengkapi meja serta tempat duduk di sentra UMKM, karena dapat dimanfaatkan oleh para pembeli UMKM sambil makan atau minum di bawah payung tersebut. Meja Payung Solar Cell (JAYUS) untuk UMKM ini nantinya bisa sebagai pusat charger handphone sekaligus tempat meja makan dan minum. Meja Payung Solar Cell di design bagian atasnya datar, nanti tenaga listrik yang di keluarkan AC dengan pertimbangan agar bisa di manfaatkan untuk menyalakan peralatan listrik.
AN ANALYSIS OF INDEPENDENT CHARACTER OF PRIMARY SCHOOL STUDENTS IN LEARNING FROM HOME DURING THE COVID-19 PANDEMIC (A Case Study at SD Muhammadiyah 8 Surabaya)
Authors: Haiq Umar , Martati Badruli , Setiawan Fajar
Published: August 2021

This research aims to determine the process of the development of the independent character of elementary school students in learning from home during the Covid-19 pandemic at SD Muhammadiyah 8 Surabaya in grades 4, 5, and 6 by referring to the achievement of indicators of independent character values and the obstacles that arise in their achievement. By using a qualitative approach, the discussion will be presented in a descriptive explanation. The research subjects are 99 upper-class student respondents (4, 5, and 6) at SD Muhammadiyah 8 Surabaya. The research is carried out only by taking data on March, April, and May 2020 as the research scope. In this research, data are collected giving online questionnaire observation techniques to students, accompanied by parents, and having direct interviews with class teachers and subject teachers. The discussion in this research shows that the level of development of the independent character of students has been built with an average of being in the category of culture and development even though there are still obstacles because they require assistance, either directly or indirectly from parents and teachers.Keywords: Character, Independence, Covid-19 Pandemic
THE APPLICATION OF ROLE PLAYING MODEL IN SOCIAL LEARNING ON GRADE IV STUDENTS’ AT SUNGAI HITAM ELEMENTARY SCHOOL
Authors: Farira Nanda , Sofiarini Andriana , Satria Tio Gusti
Published: August 2021

This study aims to determine completeness of student learning outcomes after the application of role playing model in Social learning on grade IV students at Sungai Hitam Elementary School. The method used in this research is Pre-Experimental Design. The population in this study is all grade IV of Sungai Hitam Elementary School. The research sample was taken using simple random sampling technique. Data collection techniques in the study using the test. Then the data were analyzed using the t-test. Based on the results of research and discussion it is known that the average value () of pre-test is 40,12 and the average value () of post-test is 77,71. The collected data is then analyzed using the t-test obtained tcount (3,34) ttable (1,75). It can be concluded that the learning outcomes of grade IV students’ at Sungai Hitam Elementary School after the application of role playing model in Social learning completed significantly.
Notes for contributors & Advertising rates
Authors: TESOL in Context Journal Coordinator
Published: August 2021

Notes for contributors

Advertising rates
Association Between Cardiac Enzyme Elevation and Clinical Prognosis of Neurosurgical and Neurocritically Ill Patients
Authors: Lee Jung Hwa , Lee Yun Im , Ahn Joonghyun , Ryu Jeong-Am
Published: August 2021

To investigate whether cardiac troponin (cTn) elevation is associated with in-hospital mortality and major adverse cardiac events (MACEs) in neurosurgical and neurocritically ill patients. Among neurosurgical patients admitted to the intensive care unit (ICU) from January 2013 to December 2019, those whose serum cTnI levels were obtained within 7 days after ICU admission were included. Propensity score matching was used. Each patient with cTnI elevation was matched to one of control patients. The primary endpoint was in-hospital mortality and the secondary outcome was MACE. cTnI elevation was shown in 702 (11.7%) of 6,004 patients. After propensity score matching, 617 pairs of data were generated by 1:1 individual matching without replacement. In multivariable analysis of overall and propensity score-matched population, cTnI elevation were associated with in-hospital mortality (adjusted odds ratio [OR]: 2.78, 95% confidence interval [CI]: 1.95 – 3.95 and adjusted OR: 1.77, 95% CI: 1.20 – 2.62, respectively). In addition, cTnI elevation were associated with MACE (adjusted OR: 3.75, 95% CI: 2.43 – 5.78 and adjusted OR: 4.04, 95% CI: 2.24 – 7.29, respectively). In this study, cTnI elevation was associated with in-hospital mortality and MACEs in neurosurgical and neurocritically ill patients.
Association Between Cardiac Enzyme Elevation and Clinical Prognosis of Neurosurgical and Neurocritically Ill Patients
Authors: Lee Jung Hwa , Lee Yun Im , Ahn Joonghyun , Ryu Jeong-Am
Published: August 2021

Background: To investigate whether cardiac troponin (cTn) elevation is associated with in-hospital mortality and major adverse cardiac events (MACEs) in neurosurgical and neurocritically ill patients. Methods: Among neurosurgical patients admitted to the intensive care unit (ICU) in a tertiary hospital from January 2013 to December 2019, those whose serum cTnI levels were obtained within 7 days after ICU admission were included. Propensity score matching was used. Each patient with cTnI elevation was matched to one of control patients. The primary endpoint was in-hospital mortality and the secondary outcome was MACE. Results: cTnI elevation was shown in 702 (11.7%) of 6,004 patients. After propensity score matching, 617 pairs of data were generated by 1:1 individual matching without replacement. Rates of in-hospital mortality in the overall population and the propensity score-matched population were higher for patients with cTnI elevation than for those without cTnI elevation (p < 0.001 and p = 0.003, respectively). In addition, MACEs were more common in patients with cTnI elevation than in those without cTnI elevation in the overall population and the propensity score-matched population (both p < 0.001). In multivariable analysis of overall and propensity score-matched population, cTnI elevation were associated with in-hospital mortality (adjusted odds ratio [OR]: 2.78, 95% confidence interval [CI]: 1.95 – 3.95 and adjusted OR: 1.77, 95% CI: 1.20 – 2.62, respectively). In addition, cTnI elevation were associated with MACE (adjusted OR: 3.75, 95% CI: 2.43 – 5.78 and adjusted OR: 4.04, 95% CI: 2.24 – 7.29, respectively). In survival analysis, the mortality rate of patients with cTnI elevation was significantly higher than in those without cTnI elevation for the propensity score-matched population (28.8% vs. 19.3%, log-rank test, p < 0.001).Conclusions: In this study, cTnI elevation was associated with in-hospital mortality and MACEs in neurosurgical and neurocritically ill patients.
The Seasonal Evolution of Subglacial Drainage Pathways Beneath a Soft-bedded Glacier
Authors: Hart Jane K. , Young David S. , Baurley Nathaniel R. , Robson Benjamin A. , Martinez Kirk
Published: August 2021

Subglacial hydrology is a key element in glacier response to climate change, but investigations of this environment are logistically difficult. Most models are based on summer data from glaciers resting on rigid bedrocks. However a significant number of glaciers rest on soft (unconsolidated sedimentary) beds. Here we present a unique multi-year instrumented record of the development of seasonal subglacial behavior associated with an Icelandic temperate glacier resting on a deformable sediment layer. We observe a distinct annual pattern in the subglacial hydrology based on self-organizing anastomosing braided channels. Water is stored within the subglacial system itself (till, braided system and ‘ponds’), allowing the rapid access of water to enable glacier speed-up events to occur throughout the year, particularly in winter.
Effects of Maternal Cannabis Use on the Newborn at Delivery and the Perinatal Period
Authors: Edet Angela , Cheng Philip Y. , Bhattacharyya Mouchumi , Kozik Teri M.
Published: August 2021

Background To evaluate if Activity Pulse Grimace Appearance Respiration (APGAR) scores and birthweight at delivery are different amongst newborns exposed to cannabis in utero compared to those who were not exposed to cannabis in utero. Also the rate of perinatal complications to the newborn was also examined. Methods This is a retrospective cohort study utilizing patient’s electronic health records that gave birth at a community hospital in the central valley of California in 2019. Exposure was defined as cannabis detected on universal urine toxicology testing completed on admission to hospital prior to birth/delivery. This was compared with urine toxicology testing that was negative for cannabis exposure. Results No significant difference between mothers who use cannabis and mothers who do not use cannabis during pregnancy in terms of the newborn’s one minute or five minute APGAR score. A significant difference between mothers who use cannabis compared to mothers who did not was found, in terms of the newborn’s birthweight. The rate of perinatal complications to the newborn was negligible at delivery and in the immediate perinatal period in our particular study. Conclusion To guide interventions in women of child bearing age in regards to illicit drug use in pregnancy particularly cannabis utilization. The medical knowledge of cannabis use in pregnancy is growing steadily and through continued further research; the body of knowledge can continue to grow in regards to outcomes in the newborn and the growing child.
Occurrence and characterisation of naphthenic acid fraction components in oil residues stranded on the shoreline of Chedabucto Bay, Nova Scotia, Canada
Authors: Yang Zeyu , Zhang Gong , Yang Chun , Shah Keval , Hollebone Bruce , Laforest Sonia , Lambert Patrick , Brown Carl
Published: August 2021

Purpose

This study aimed to investigate the occurrence, fate, and behaviour of oil components 46 years post-spill by analysing polar naphthenic acid fraction components (NAFCs).
Methods

Oil residues and sediment samples were collected from the shoreline of Chedabucto Bay, Nova Scotia, Canada, at sites affected by the 1970 Arrow oil spill, in June 2016. Sediments were extracted with Soxhlet extraction; NAFCs were separated through a silica gel column firstly, then analysed by high-performance liquid chromatography–high-resolution mass spectrometry (HPLC-HRMS).
Results and discussion

In all samples, the most abundant NAFC species were those having only oxygen as the heteroatom (Oo species, o indicating the number of oxygen atoms, from 1 to 8) and a high degree of saturation. O2 species accounted for 50–70% of all Oo species. NAFCs with sulphur heteroatoms were the second abundant species, then by those containing both nitrogen and oxygen heteroatoms. NAFCs in most Arrow oil residues had higher levels of oxygen species, especially for heavier molecular weight congeners, than the oil remaining stored in the sunken tanker. Environmental sediment samples, collected from near a marina away from the spill site, mainly contained a biological contribution with obviously recent petroleum oil input, whereas all Arrow oil residues were composed mainly of NAFCs that are characteristic of petroleum, and varied abundance between sites.
Conclusions

Characteristics of NAFCs from different sources varied from each other. Site-specific environmental conditions played a major role in controlling the fate and behaviour of oil components, including NAFCs.
Oxidative Medicine and Cellular Longevity Hsa_circ_0013731 mediated by E2F1 inhibits ferroptosis in hepatocellular carcinoma cells by sponging miR-877-3p and targeting SLC7A11
Authors: Fang Shiji , Chen Weiqian , Ding Jiayi , Zhang Dengke , Zheng Liyun , Song Jingjing , Tu Jianfei , Zhao Zhongwei , Qiu Rongfang , Weng Qiaoyou , Lu Chenying , Yang Yang , Ji Jiansong
Published: August 2021

Background: The regulatory loop between circular RNAs and microRNAs has a vital role in cell death. Ferroptosis is the form of iron-dependent cell death, which is distinct from necroptosis and apoptosis. Increasing evidences showed that ferroptosis is an important form of cell death in hepatocellular carcinoma.Methods: Real-time PCR were used to examine the expression level of circ_0013731 in hepatocellular carcinoma tissues. Edu and colony formation were performed to detect the cell proliferation. A luciferase reporter assay was used to determine the relationship between circ_0013731, miR-877-3p and SLC7A11. ChIP-qPCR assays were performed to examine the potential binding of E2F1 to the circ_0013731 promoter. Iron Assay Kit (Sigma Aldrich) was used to detect total iron or Fe2+. C11 BODIPY 581/591 staining and flow cytometer were used to examine the Lipid ROS. The role of circ_0013731 was examined in xenograft tumors model. Results: We revealed that the expression level of circ_0013731 was elevated in hepatocellular carcinoma. Moreover, E2F1 promote the transcription of circ_0013731. Overexpression of circ_0013731 promoted cell growth and inhibited ferroptosis in SMMC-7721 and QGY-7703 in vitro. miR-877-3p was proved as the direct target of circ_0013731. Then, inhibition of miR-877-3p enhanced cell growth and inhibited ferroptosis. Further mechanism research demonstrated that circ_0013731 upregulated the expression level of SLC7A11 by sponging miR-877-3p. Finally, circ_0013731 promoted HCC growth via miR-877-3p/ SLC7A11 axis in vivo.Conclusions: Our data reveal that circ_0013731 mediated by E2F1 facilitates cell growth and suppressed the ferroptosis via miR-877-3p/ SLC7A11 axis in hepatocellular carcinoma. Therefore, circ_0013731 could be acted as potential therapeutical target for hepatocellular carcinoma.
Comparison of Double-Lumen Tube and EZ-Blocker for Lung Separation in Thoracic Surgery - A Randomised Controlled Clinical Trial
Authors: Risse Joachim , Szeder Karsten , Schubert Ann-Kristin , Wiesmann Thomas , Dinges Hanns-Christian , Feldmann Carsten , Wulf Hinnerk , Meggiolaro Karl Matteo
Published: August 2021

Background:Double lumen tube (DLT) intubation is the most commonly used technique for lung separation. Bronchial blockers (BB) are an alternative, especially for difficult airways. The EZ-bronchial blocker (EZB) is the newest device of the BB family. Methods:A randomised, controlled trial was conducted in 80 patients undergoing elective thoracic surgery using DLT or SLT plus EZB for lung separation (German Clinical Trial Register DRKS00014816). The objective of the study was to compare the clinical performance of EZB with DLT. Primary endpoint was total time to successful lung separation. Secondary endpoints were time subsections, quality of lung collapse, difficulty of intubation, any complications during the procedure, incidence of objective trauma of the oropharynx and supraglottic space and intubation-related subjective symptoms.Results:74 patients were included, DLT group (n = 38), EZB group (n = 36). Median total time for lung separation [IQR] in DLT group was 234 seconds [207 to 294] versus 298 seconds [243 to 369] in EZB group (P=0.007). Quality of lung collapse was equal in both groups, DLT group 89.5% were excellent vs. 83.3 % in the EZB group (P=0.444). Inadequate lung collapse in five patients of the EZB group resulted in unsuccessful repositioning attempts and secondary DLT placement. Endoscopic examinations revealed significantly more carina trauma (P=0.047) and subglottic haemorrhage (P=0.047) in the DLT group. Additionally, postoperative subjective symptoms (sore throat, hoarseness) were more common in the DLT group, as were speech problems.Conclusions:Using the EZB results in prolonged lung separation compared to DLT, prima facie with equal quality of lung collapse for the thoracic surgeon. Five crossover cases demonstrated the superiority of the use of left-sided DLT especially in the indication for EZB for a right open thoracotomy or right video-assisted thoracoscopic surgery (VATS). Using the EZB showed only little evidence for reducing objective airway trauma e.g. less carina trauma as well as subjective complaints.Trial registration:German Clinical Trial Register DRKS00014816, prospectively registered on 07.06.2018https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00014816
Resistance Traits and Molecular Characterization of Multidrug-resistant Acinetobacter baumannii Isolates from an Intensive Care Unit of a Tertiary Hospital in Guangdong, Southern China
Authors: Chen Zhuo-Ran , Guo Hui-Wu , Pan Qing , Fu Mao-Zhang , Qiu Ying-Kui , Liu Jun , Wong Nai-Kei , Huang YuanChun
Published: August 2021

Purpose: This study aims to characterize antimicrobial resistance (AMR), with particular reference to carbapenems and aminoglycosides, in MDR A. baumannii isolates recovered from an intensive care unit in a tertiary hospital. Methods: A. baumannii (n = 95 strains) isolated from patients were subjected to antimicrobial susceptibility test (AST) by Vitek 2 Compact system to determine minimum inhibitory concentrations, followed by genotyping by enterobacterial repetitive intergenic consensus-PCR (ERIC-PCR). Resistance genes of interest were PCR-amplified and sequenced. Results: All isolates were qualified as MDR, with a resistance rate of >80% to 8 antimicrobials tested. In terms of beta-lactamase detection, the blaOXA23 and blaTEM-1 genes were detected frequently at 92.63% and 91.58%, respectively. The metallo-β-lactamase genes blaIMP, blaVIM, and blaNDM were undetected. Aph (3’)-I was detected in 82 isolates (86.32%), making it the most prevalent aminoglycoside-modifying enzyme (AMEs) encoding gene. In addition, ant (3”)-I was detected at 30.53%, while 26.32% of the strains harboured an aac (6')-Ib gene. ERIC-PCR typing suggested moderate genetic diversity among the isolates, which might be organized into 10 distinct clusters, with Cluster A (n = 86 isolates or 90.53%) being a dominant cluster of epidemic clones.Conclusions: Substantial fractions of the A. baumannii strains prevailing in the ICU were MDR clones exhibiting extremely high resistance to carbapenems and aminoglycosides as monitored throughout the study period. They principally belonged to a single cluster of isolates carrying blaOXA23 and armA co-producing different AMEs genes.
The Cryoprotective Potential of Propolis Supplemented in Frozen-Thawed Bull Semen: Biochemical and Physiological Findings
Authors: Yeni Deniz , Gülhan Mehmet Fuat , İnanç Muhammed Enes , Avdatek Fatih , Güngör Şükrü , Türkmen Ruhi , Tuncer Pürhan Barbaros , Tasdemir Umut
Published: August 2021

In this study, the cryoprotective effect of different doses of propolis (P) on bull semen, which has strong pharmacological properties thanks to its rich phenolic components, was investigated biochemically and physiologically. Semen samples were collected from Simmental breed bulls via the artificial vagina and pooled. After dividing into five groups, control (C: no additive), and four different dose P (200, 100, 50, and 25 μg/mL) groups, the final concentration was diluted to 16×106 per straw. Semen samples were equilibrated at 4°C for approximately 4 hours, then placed in French straws and frozen. After thawing, sperm motility and kinetic parameters, DNA integrity by single-cell gel electrophoresis, sperm abnormalities by liquid fixation, and lipid peroxidation levels by the colorimetric method was analyzed by Computer-Assisted Semen Analyzer. P added to the diluent showed no effect on motility and kinetic parameters at P25 and P50 (p >0.05), while P100 and P200 had a negative effect (p <0.001). The addition of P (25 and 50) had a treatment effect on tail abnormality compared to C (p <0.05). Especially P50 had a positive effect on tail length, tail DNA, and tail moment, while P100 and P200 caused DNA damage (p <0.001). MDA levels increased in all P dose groups compared to C (p <0.001). This study has clearly demonstrated that P25 and P50 supplements could be used therapeutically in the treatment of sperm abnormalities and prevention of DNA damage in post-thawed bull sperm.
Fine Mapping of A QTL Locus (QNFSP07-1) And Analysis of Candidate Genes For Four-Seeded Pods In Soybean
Authors: Li Yingying , Liu Chunyan , Wang Nannan , Zhang Zhanguo , Hou Lilong , Xin Dawei , Qi Zhaoming , Li Candong , Yu Yan , Jiang Hongwei , Chen Qingshan
Published: August 2021

The number of four-seeded pods is a quantitative trait in soybean [Glycine max (L.) Merr.] and is closely related to yield in terms of breeding. In this study, individuals with high ratio of four-seed pods which from chromosome segment substitution lines (CSSLs) that can be stably inherited were selected as the parent, and Suinong 14 (SN14) was used as recurrent parent to construct secondary mapping population via marker-assisted selection. The initial QTL mapping interval was 0.67 Mb and was located on Gm07. Based on the initial QTL mapping results, individuals that were heterozygous at the interval (36116118-37399738 bp) were screened, and the heterozygous individuals were subjected to inbreeding to obtain 13 F3 populations, with a target interval of 321 kb. Gene annotation was performed on the finely mapped interval, and 27 genes were obtained. Glyma.07G200900, Glyma.07G201200 were identified as candidate genes. qRT-PCR was used to measure the expression of the candidate genes at different developmental stages of soybean. The expression levels of the 2 candidate genes in terms of cell division (axillary buds, COTs, EMs) were higher than those in terms of cell expansion (MM, LM), and these genes play a positive regulatory role in the formation of four-seeded pods. Haplotype analysis shows that Glyma.07G201200 has two excellent haplotypes. Those results provide the information for gene map-based cloning and molecular marker assisted breeding of the number of four-seeded pod in soybean.
Food Insecurity is Associated with Additional Severe Maternal Hardships during Pregnancy: Results from the 2012-2014 California Maternal Infant Health Assessment
Authors: Laraia Barbara , Gamb Ryan , Saraiva Carina , Dove Melanie , Marchi Kristen , Braveman Paula
Published: August 2021

Background: Assess the associations between food insecurity and ten additional maternal hardships experienced during pregnancy.Methods: Data on 14,274 low-/middle-income women from the statewide-representative 2010-2012 California Maternal and Infant Health Assessment were used to estimate food security status and prevalence of additional maternal hardships. Multinomial logistic regression was used to assess the associations between food security status—secure, marginal, low and very low—and these hardships. Results: Food insecurity was common (23%) among all pregnant women in California. Among women with incomes at or below 400% of the income to federal poverty guideline ratio, nine of ten hardships were independently associated with food security status; only the respondent or someone close to the respondent having a problem with alcohol or drugs was not independently associated with food security status after adjusting for socioeconomic factors. Husband/partner losing a job, depressive symptoms, not having practical support and intimate partner violence were consistently associated with marginal, low and very low food security status. Each additional severe maternal hardship a woman experienced during pregnancy was associated with a 36% greater risk of reporting marginal food security (Relative Risk Ratio 1.36, 95% CI: 1.27, 1.47), 54% for low food security (Relative Risk Ratio 1.54, 95% CI: 1.44, 1.64), and 99% for very low food security (Relative Risk Ratio 1.99, 95% CI: 1.83, 2.15). Conclusions: Food security status was strongly linked with several serious maternal hardships that could jeopardize maternal and/or infant health. Policy implications: Services—including prenatal care and nutritional assistance—for a large proportion of pregnant women should address a wide range of serious unmet social needs including food insecurity.Significance Statement: During pregnancy, food insecurity is common and is strongly associated with additional severe maternal hardships that could threaten maternal and infant health.