bluuebunny/crossref_metadata_2025 huggingface dataset:
Complexity of diagnosis and management of a giant thyroid nodule: A case report and a concise literature
Authors: Firdausa Sarah , Zufry Hendra , Ekadamayanti Agustia S. , Sucipto Krishna W. , Burhan Henry W. , Pratama Sergio , Benalcazar Andrés MMB.
Published: October 2023

It is crucial for doctors to decide whether a thyroid nodule is benign or malignant when a patient presents with one, as it will significantly impact how the patient is managed in the future. However, it is not as straightforward to determine between the two; even a physical examination, thyroid function test, ultrasonography, and biopsy have been well performed. It can be more stressful if a patient has an increased risk of malignancy, such as age (below 20- and above 60-year-old), solid nodule, rapid growth, hoarseness, lymphadenopathy, and microcalcifications on the ultrasonography. The aim of this case was to present the management of a giant thyroid nodule with malignancy presentation and a benign biopsy finding. A 41-year-old male complained of a palpable neck mass, hoarseness, and dysphagia. The thyroid function test was normal. Ultrasonography revealed suspicion of malignancy with category 4 of American College of Radiology-Thyroid Imaging Reporting and Data System (ACR-TIRADS). The biopsy revealed follicular neoplasm, and was classified as Bethesda IV. The patient underwent a total thyroidectomy due to the large tumor size and symptoms. Histopathological findings post-surgery revealed a follicular thyroid adenoma. This case highlights a complex diagnosis and management of follicular thyroid neoplasm due to their potential for both benign and malignant. Comprehensive pre- and post-operative care is essential to determine the nature of nodules. Post-operative follow-up care might improve the patient’s outcome and prevent complications.
Palliative radiotherapy for leptomeningeal metastases after photon-based intensity-modulated radiotherapy in a nasopharyngeal cancer patient
Authors: Marlina Yoke S. , Novirianthy Rima , Beočanin Anđelija
Published: October 2023

Leptomeningeal metastasis is a rare in nasopharyngeal carcinoma, affecting less than 5% of patients with a poor prognosis. The aim of this case report was to present management of palliative radiotherapy in leptomeningeal metastasis of nasopharyngeal carcinoma patient. A 33-year-old female presented with nasopharyngeal carcinoma with stage III, T3N3M0, WHO type III. The patient has received chemoradiation with photon-based intensity-modulated radiotherapy (IMRT) technique at the dose of 70 Gy in 33 fractions and showed a satisfactory outcome in 12 months follow-up. Later, at 18 months after chemoradiation completion, the patient complained of worsening bilateral sciatic pain, particularly during coughing, with slight limitations in bilateral hip flexion observed during straight leg raises. The whole spine contrast-enhanced magnetic resonance imaging (MRI) examination showed nodular enhancement of leptomeningeal thickening at the T4 level of the spinal cord lower than S3. Palliative radiation therapy utilized a three-dimensional conformal radiation therapy (3D-CRT) technique producing 35 Gy in 14 fractions placed in a field spanning the T4-S3 vertebral bodies. Methotrexate was administered intravenously every two weeks for three cycles to ensure central nervous system penetration. After four months of follow-up, no evidence of disease was found at the primary site and metastatic areas on subsequent physical examination or imaging with MRI and there was satisfactory improvement in neurologic symptoms. In conclusion, leptomeningeal metastases with primary nasopharyngeal carcinoma are rare and typically cause neurological impairments in patients. Hematogenous or cerebrospinal fluid-mediated spread of the cancer is considered the most likely pathway for leptomeningeal dissemination. Strategic modalities, such as radiotherapy with chemotherapy, may improve outcomes in symptoms and quality of life.
PHYSICAL HEALTH RELATED QUALITY OF LIFE IN PAKISTANI PHYSICAL THERAPISTS
Authors:   Isra Institute of Rehabilitation Sciences, Isra University Islamabad. Pakistan, Liaqat Maria , Kanwal Raheela ,   Department of Physiotherapy, University of Hail Riyadh Saudi Arabia, Ansari Misha ,   School of Health Sciences. University of Tasmania. Australia, Munir Sonia ,   Isra Institute of Rehabilitation Sciences, Isra University Islamabad. Pakistan
Published: October 2023

Objectives: The objective of this study is to find out the quality of life (QOL) related to physical health and factors associated with it in physical therapists of Pakistan. Materials & Methods: Descriptive cross sectional survey was conducted among physiotherapists of Pakistan working in different hospitals and teaching institutes. The sample (n=378) was collected through convenient sampling technique. The qualified doctors of physical therapy with age of 22-50 years were included. Data was collected by using General demographic questionnaire including age, gender, qualification, marital status, job type, job nature, financial issues, family issues, job satisfaction, salary satisfaction, overall satisfaction, depression anxiety stress (DAS) and physical health related quality of life (WHO-QoL). Data was analyzed by using SPSS 21. Results: The results showed that mean age of study participant was 29.66±3.75. the average population of PTs had normal physical health(49.53±15.17). A total of n=146(38.64%) physical therapist had good, n=90(23.81%) had normal, n=136(35.98%) had poor and n=6(1.59%) had very poor quality of life related to their physical health. Physical health was found poor among PTs those who were divorced (37.33±9.81), severely depressed (32.27±13.09), in severe anxiety (32.75±3.24) and severely stressed (31.00±.00). Conclusion: Average population of PTs had normal physical health. The physical health was associated with gender, type of job, nature of job, financial issues and family issues. Physical health becomes poorer as depression, anxiety and stress severity increases. Keywords: Physical Therapist, quality of life, Depression, anxiety, stress. Work related musculoskeletal disorders.
EFFECTIVENESS OF GRADED MOTOR IMAGERY IN PAIN AND DISABILITY AFTER ROTATOR CUFF INJURY
Authors:   Pakistan Air Force Special Education School. Islamabad. Pakistan, Malik Shomaila , Aslam Saima ,   Isra Institute of Rehabilitation Sciences, Islamabad. Pakistan, Soomro Suhail Karim ,   Department of Physical Therapy, Shifa Tameer-e-Millat University, Islamabad.. Pakistan., Malik Summayya Zaman ,   Department of Physical Therapy, Isra Institute of Rehabilitation Sciences, Islamabad. Pakistan, Rauf Danish ,   Institute of Medical Rehabilitation, Islamabad. Pakistan
Published: October 2023

Objective: to determine the effects of graded motor imagery (GMI) on pain and disability in rotator cuff injuries. Methodology: A Randomized Control Trial conducted at national institute of rehabilitation medicine (NIRM) after the approval from the executive director. A total n=40 subjects were recruited through non probability convenient sampling technique and allocated randomly in the Conventional physical therapy (CPT) (n=20) and the graded motor imagery (GMI) group (n=20). Patients with age range 25-50 years having history of trauma with positive impingement sign were included and patient with diabetes were excluded from the study. The data was collected through General demographic questionnaire included age, gender, ADLs, Diabetes, Hyper tension etc. Shoulder Pain and Disability Index (SPADI) was used to measure current shoulder pain and disability in an outpatient setting. Data was compared at baseline and after 2nd week and 4th week. Results: The mean age of the study participants was 38.67±7.437 years. Within-group changes showed that both group improved significantly (p≤0.05) from 0-4th week regarding total shoulder pain and disability score. While comparing the both groups, significant improvement (p≤0.05) was found in as compare to conventional PT group. Conclusion: graded motor imagery (GMI) and conventional PT both are effective for management of pain and disability due to rotator cuff injuries. But GMI was found to be more effective than conventional PT. Keyword: rotator cuff injury, graded motor imagery, pain, disability, phantom limb pain
Understanding the Role of Physical Education Teacher Training Institutions and Managerial Style in Development of Student Attitudes
Authors: Abdur Rehman  , Khan Salahuddin , Kausar Salma
Published: October 2023

The purpose of this study is to understand the role of physical education teacher training institutions in the development of student attitudes. Both males and females were the population of this study. The researcher therefore selected the entire population for the study due to its approachable nature. A self-constructed structured questionnaire, including the variables of the study, was developed and used by the researchers. A total of 125 questionnaires were distributed to 77 males and 48 female students, and 81 students from Gomal University and 44 from Sarhad University. 125 questionnaires were received back, which the researcher entertained in data analysis. The researcher set .05 significant level to test the formulated hypotheses. After the analysis of the collected responses, the researcher found and concluded that from the concern study, that before the training there was no difference in professional attitudes of students which enrolled in physical education training institutions (PETTI) of Gomal and Sarhad University. After training in professional attitudes of students enrolled in physical education teacher training institutions (PETTI) of Gomal and Sarhad University was found, and Gomal University have high average as compared to the Sarhad University. It means that public university are more suitable in professional attitudes for students.
Interpretative Phenomenological Perceptional Study of Women Entrepreneurs Facing Challenges in Entrepreneurial Activity in the Horn of Africa
Authors: Adula Metasebia , Kant Shashi
Published: October 2023

This study aims to explore the challenges facing the perception of women entrepreneurs in the Bole Hora town administration, Ethiopia, Horn of Africa. Related to the challenges faced in the perception, attitude, and belief of women entrepreneurs, in-action and the potential women are segregated. The researchers used a qualitative research design related to the interpretative approach. The researchers interviewed eight women entrepreneurs involved in the venture start-up. The purposive sampling technique was used to get primary data from the respondent with the help of a structured interview. For qualitative data analysis, the thematic data analysis method was used. The major findings of the study showed that challenges faced by the women entrepreneurs in the study area were lack of finance, working place, training, and social-cultural factors. The implication of the study will help the government to revise its policy to give a solution to individual and organizational–related, legal/administration, economic, social/cultural, and other factors that affect the perception of women entrepreneurs about entrepreneurial activity.
Exploring the Impact of Artificial Intelligence and Digital Transformation on Auditing Practices in Saudi Arabia: A Cross-Sectional Study
Authors: Alhumoudi Hamad , Abdulrahman Juayr
Published: October 2023

The advent of digital technologies and the increasing adoption of artificial intelligence (AI) have transformed various industries and firms, including auditing. Manual auditing procedures have proven to be time-consuming and labor-intensive, leading to lower audit quality and higher costs. The integration of digital transformation and AI in auditing practices offers potential solutions to enhance efficiency and effectiveness in Saudi Arabia. Therefore, this research focuses on examining the impact of digital technologies and AI on audit efficiency, effectiveness, challenges faced during adoption, adjustments in auditors' roles, and the regulatory and ethical considerations arising from the integration. A cross-sectional research design was adopted to collect data from a sample of 400 participants through an online survey, analyzed by statistical tools, including descriptive statistics and correlation and examined the relationships between variables. The findings indicate a positive relationship between the level of digital transformation and the adoption of AI in auditing practices in Saudi Arabia, along with significant challenges, such as resistance to change, technological infrastructure, skills gap, and regulatory compliance concerns, paving a way for further advancements in the field of auditing and digital transformation.
Validation and Reliability Study of The Aggression Proneness Scale for Children Aged 60-72 Months
Authors: SEVEN Serdal , ESKİDEMİR MERAL Seda , UÇAR ÇABUK Feyza
Published: October 2023

This study aims to conduct the validity and reliability analysis of the “Aggression Tendency Scale” developed by Cassidy et al. (1996), in children aged 60-72 months. The study group of the research consists of 221 children aged 60-72 months who attend pre-school educational institutions in Antalya's city center and have different sociodemographic characteristics. In the analysis of the data; exploratory factor analysis, confirmatory factor analysis, content validity, test-retest reliability, and internal consistency coefficient (Cronbach's alpha) have been calculated. Opinions have been obtained from 12 experts to determine content validity. Based on expert opinions and suggestions, it has been decided to retain 6 items in the scale. Confirmatory factor analysis has been conducted with the data obtained from the applications performed with the scale that achieved content validity. As a result of the analyses performed, it has been determined that the 6-item structure of the scale generally complies with the collected data. The internal consistency coefficient of the scale has been found to be 0.772. Additionally, the correlation coefficient was found to be 0.782 as a result of the test-retest reliability analysis of the scale. These results have shown that the Aggression Tendency Scale is a valid and reliable tool in evaluating the aggression tendencies of children aged 60-72 months.
Romanya’daki Kur’ân Meallerinin Kur’ân Çeviri Kriterleri Açısından Değerlendirilmesi
Authors: Cherim Enghin
Published: October 2023

Romanya gibi Müslüman olmayan ülkelerde yaşayan ve Arap diline hâkim olmayan kimseler için Kur’ân tercümelerinin hayatî bir öneme sahip olduğunu vurgulamak gerekir. Zira bu ve benzeri ülkelerde yaşayan insanlar, İslâm’ın kaynağına ve mesajlarına ancak tercümeler ve bu konuda yapılmış çalışmalar vasıtasıyla ulaşabilmektedir. Bu durum bölgede yaşayan gayrî müslim nüfus için de geçerlidir. Nitekim Kur’ân tercümeleri üzerinden yapılan bir okuma sonucunda Müslüman olmayan kişi İslâm’ı kabul etmese dahi bunun sonucu olarak ya İslâm diniyle ilgili olumlu kanaatleri oluşmakta ya metinle yeterli ünsiyet kuramadığından Kur’ân tercümesini etraflıca okumaktan imtina etmekte ya da metne bir daha geri dönmemek üzere kısa sürede ilgili meal çalışmasını rafa kaldırmamaktadır. Bu araştırmada, “Kur’ân nasıl bir kitaptır? Doğru bir Kur’ân tercümesi nasıl yapılır? Mütercim bu hususta hangi kriterlere dikkat etmelidir? Hangi tercüme metodu kullanılmalıdır? Kur’ân’ın tercümesi herhangi bir kitabın tercümesine benzer mi?” gibi sorular temelinde başarılı bir Kur’ân tercümesini mümkün kılacak kriterler tespit edilmeye çalışılmıştır. Bunun için de Romence Kur’ân tercümelerinden seçilen örnek metinlerden hareketle bu kriterlerin hangisine ne ölçüde riayet edildiğini göstermek amaçlanmıştır.
Kur’ân’da Ruhani Varlıkların Mahiyeti: Mealler Üzerinden Bir İnceleme
Authors: Karaosman Muhammet
Published: October 2023

İnsanlığa hidayet rehberi olarak nâzil olan Kur’ân, ana dili arapça olmayan ülkelerde tercümeler yoluyla okuyucuyla buluşmaktadır. Bu yüzden mealler, Kur’ân’ın manalarından haberdar olma amacına matuf olarak ana dili Arapça olmayan toplumlar için önemli bir yere sahiptir. Bu ihtiyaca bağlı olarak günümüze kadar Kur’ân’ın farklı dilde pek çok çevirisi yapılmıştır. Kur’ân’ın Türkçeye çeviri faaliyeti de artarak devam etmektedir. Bu yoğun meal faaliyeti aynı zamanda birtakım problemleri de beraberinde getirmektedir. Bu problemlerden bir kısmı dil, üslup, tercüme teknikleri gibi hususlarla alakalıdır. Bunun yanında, meal yazarının ön kabullerinin, ideolojik yaklaşımlarının da meallerde birtakım sorunlara yol açtığı görülmektedir. Kur’ân’ı okuyucuyla buluşturması arzulanan mealler arasında bu tür olumsuz örneklerin olması, okur açısından meal seçiminin son derece önemli bir husus olduğunu ortaya koymaktadır. Bu doğrultuda Kur’ân’ın ele aldığı konulardan biri olan “ruhani varlıklar” Kur’ân’da ve meallerde yer almaları itibarıyla incelenmiştir. Bu vesileyle meallerde işlenen ruhani varlıkların ne derece Kur’ân’ı yansıttığı ve Kur’ân’ı anlama yöntemlerine ne derece riayet edildiği ortaya konulmuştur. Kur’ân’da yer alan iblis/şeytan, melek ve cin kavramları; örnek olarak ele alınan meallerde te’vil, anlambilim ve yorumbilim gibi Kur’ân’ı doğru anlama ilkeleri çiğnenerek anlaşıldığı tespit edilmiştir. Bu çerçevede melekler bereket, sevgi, merhamet; iblis/şeytan düşünce yetisi; cin ise ışın, radyasyon, ajan ve casus olarak açıklanarak çağdaş paradigmaların Kur’ân’a dayatılmaya çalışıldığı gözlemlenmektedir. Çalışmamız doküman incelemesi ve içerik analizi yöntemi ile yapılmıştır. Buna göre çalışmada Hakkı Yılmaz ve R. İhsan Eliaçık’ın mealleri merkeze alınmıştır. Bu mealler konumuzla ilgili çokça örnek içermeleri nedeniyle tercih edilmiştir.
İslam Siyaset Düşüncesi Açısından Zıllullâh Hadisi Ve İşârî Yorumları
Authors: İmamoğlu Abdullah Taha , Öztürk Özkan
Published: October 2023

İslâm siyaset düşüncesinde sıklıkla atıf yapılan hadislerden birisi de sultanın Allah’ın yeryüzündeki gölgesi olduğunu ifade eden ve hadis kaynaklarında zıllullâh hadisi olarak bilinen rivayettir. Bu çalışmada söz konusu hadisin tüm tarikleri tespit edilmeye çalışılarak kaynakları ortaya konulacak, tahriç edilip değerlendirilecek ve klasik dönem hadis şerh edebiyatındaki yorumlarına değinilecektir. İslâm siyaset düşüncesi metinlerinde hadise yapılan atıflar dikkate alınarak mezkûr hadisin önemi ortaya konulacaktır. Öte yandan hadise müracaat edilen eserlerdeki siyasi bakış açılarıyla hadisin münasebeti kurulmaya çalışılarak mezkûr rivayete dair değerlendirmeler de dikkate alınacaktır. Neticede zıllullâh hadisinin İslam siyaset düşüncesindeki yeri ortaya konulacak ve hadisle ilgili güncel ve işârî yorumlar tartışmaya açılacaktır.
DECA PREDŠKOLSKOG UZRASTA: PROCENA KROZ POKRET, RITAM I DALKROZ METODU
Authors: Pudja Milica , Lazić Svetlana
Published: October 2023

Kako se mozak deteta postepeno razvija, tako se stiču neke nove sposobnosti koje implicite utiču na razvoj motorike, govora, socio-emocionalni i kognitivni razvoj. Za svaki razvojni period postoje pokazatelјi koji okvirno pokazuju šta bi dete trebalo da ume u određenom uzrasnom periodu. Neizostavno je i delovanje iz okruženja, koje se realizuje radi unapređivanja razvoja deteta i dosezanja dobrobiti. Cilj rada jeste procena razvoja dece u odnosu na teoriju kognitivnog razvoja, kretnih sposobnosti i povezivanja pokreta sa muzikom. Na nivou različitih uzrasta dece iz uzorka istraživanja, prikazane su različite faze razvoja, kao i umeća i sposobnosti dece. Razvoj dece iz uzorka potvrđuje postulate teorije kognitivnog razvoja, što važi i za kretne aktivnosti dece, posebno u domenu krupne i fine motorike. Na pomenuto se nadovezuje uvođenje muzike kao stimulusa za pokret u skladu sa Dalkroz metodom. Deca su slušala muzičke interpretacije raznih muzičkih žanrova. Svako dete na uzrastu do 3 godine je na sebi svojstven način iskazivalo emociju koju je osećalo u datom trenutku tokom slušanja muzike, dok su starija deca pratila ritam uz jedinstvene pokrete.
PRESCHOOL UPBRINGING AND EDUCATION IN MACEDONIA
Authors: Sivevska Despina , Jadranka Runčeva
Published: October 2023

The first, initial and inseparable part of the unique educational system is the organized institutional preschool upbringing and education. Early childhood education plays a key role in children's development and has significant positive socio-economic effects on the entire society. Numerous researches in the world and in our country show that the language, cultural level, general living conditions and the specific way of upbringing and education of the child in the preschool period have a great influence on the child's psychological development and the development of the abilities needed to start school. The paper first gives an overview on the importance and significance of the organized institutional upbringing and education of preschool children, and then we focus on some aspects of the organization of preschool upbringing and education in the Republic of North Macedonia. We briefly give an overview of the growth of institutional preschool care in the last ten years, and we refer to the challenges faced by preschool upbringing and education in Macedonia.
EVALUATION OF THE RELATIONSHIP OF POSTPARTUM DEPRESSION AND SOCIAL SUPPORT IN WOMEN WITH VAGINAL AND CESAREAN DELIVERY
Authors: ŞAHİN Sevil , GÜLER Döndü , ÖZDEMİR Kevser , ÜNSAL Alaettin
Published: October 2023

Objective: This study was conducted to determine the prevalence of postpartum depression in women following normal vaginal delivery and caesarean section, to review some variables that are believed to be associated and to assess the relationship between the level of social support and postpartum depression.

Material and methods: This is a cross-sectional study conducted on postpartum women presented to a Training and Research Hospital’s Gynecology Polyclinic in Sakarya between January and June 2019. The study group consisted of 710 women in total. In the study group, 355 women had normal vaginal delivery and 355 women had Caesarean section. The Edinburgh Postnatal Depression Scale was used to determine the level of postpartum depression. Level of social support was assessed with the Multidimensional Scale of Perceived Social Support. The questionnaire forms prepared in line with the study objective were completed by the investigators with face-to-face interview method. Chi-square test, Student’s t-test and Mann-Whitney U test were used for statistical analyses. Statistical significance value was accepted as p ≤ 0.05.

Results: The age of women in the study group ranged from 19 to 43, with a mean age of 28.96 ± 5.40 years. Prevalence of postpartum depression was found to be 24.4% in this study. Prevalence of postpartum depression was 21.7% in women who had normal vaginal delivery and 27.0% in women who had Caesarean section. In the Caesarean section group, postpartum depression was higher in women whose educational level is secondary school and lower, whose family income level is poor, those with a history of any health problem during pregnancy, those with no history of food craving during pregnancy, those who gave birth to a baby with a birth weight of
Pediatri Hekimlerinin Bağımlı Hastaları Damgalama Düzeylerine Bağımlılık Eğitiminin Etkisi
Authors: KARDAŞ Ömer , GÜMÜŞSOY Ahmet Sefa , TANIR Muhammed Furkan , BAŞKAN Ayşe Hilal
Published: October 2023

Amaç: Ruhsal hastalıklar arasında en sık damgalanan hastalar bağımlı bireylerdir. Bağımlılıkta damgalama; daha kötü prognoz, daha sık relaps, daha az tedavi başvurusuyla ilişkilendirilmiştir. Bu nedenle bu çalışmada pediatri hekimlerinin bağımlılık ile ilgili damgalama düzeyinin ölçülmesi, bu hekimlere verilecek eğitimin damgalama düzeyine etkisi araştırılmıştır.

Yöntem: Pediatri anabilim dalı’nda çalışan hekimlere “Bağımlı Ergene Yaklaşım” adlı seminer verilmiştir. Katılımcılara, sosyodemografik bilgiler ile kullanılması planlanan “Yedam Madde Bağımlılığı Stigmatizasyon Ölçeği (YMSÖ)” maddelerinin yer aldığı form tek sayfa halinde eğitim öncesinde ve sonrasında uygulanarak analiz edilmiştir.

Bulgular: Örneklemin 18 (%69,2)’i kadın, 8 (%30,8)’i erkek, yaş ortalaması 37,8±11,6’di. Tüm örneklemin YMSÖ ortalama puanı eğitim öncesi 17,7±5,1, eğitim sonrası 16±5,3 olarak saptanmıştır. Bu değişim istatistiksel olarak anlamlıydı (p
Rituksimab Dışı Biyolojik İlaç Kullanan Hastalarda Hepatit B Seroprevalansı ve Reaktivasyon Sıklığı; Tek Merkez Sonuçları
Authors: ÖZDEMİR IŞIK Özlem , BASARAN Enes , GÖKÇEN Neslihan , TEMİZ KARADAĞ Duygu , YAZICI Ayten , ÇEFLE Ayşe
Published: October 2023

Amaç: Biyolojik ilaçlar, romatolojide önemli tedavi alternatifleridir. Bu ilaçların kullanımı sırasında hepatit B reaktivasyonu gelişebilmektedir. Rituksimab (RTX) dışı biyolojik ilaçlarla hepatit B reaktivasyon sıklığı net değildir. Çalışmada, RTX dışı biyolojik ilaç tedavisi alan hastalarda hepatit B seroprevalansı ve reaktivasyon sıklığını değerlendirmek amaçlanmıştır.

Yöntem: 2010-2022 yılları arasında farklı endikasyonlarla RTX dışı biyolojik ilaç tedavisi alan 170 hastanın HBsAg, anti-HBs, anti-HBcIgG verileri retrospektif olarak incelendi. Reaktivasyon açısından viral yük, karaciğer enzim yüksekliği ve HBeAg reversiyonu değerlendirildi.

Bulgular: Hastaların %53,5'i erkek, yaş ortalamaları 47,4±10,6 yıl idi. Tüm grupta hastaların %80’i anti-tümör nekroz faktör (TNF), %20’si TNF dışı biyolojik ilaç tedavisi kullanılmaktaydı. HBsAg (+) olanlar grup 1 (%2,9), HBsAg (-), anti-HBs (+) ve anti-HBcIgG (+) olanlar grup 2 (%7,6), anti-HBcIgG (+) olanlar grup 3 (%8,2), viral serolojisi negatif olanlar grup 4 (%67,1) ve aşı ile bağışıklanmış anti-HBs (+) olanlar ise grup 5 (%14,1) olarak sınıflandırıldı.

Grup 1'deki hastalar antiviral tedavi almaktaydı. Diğer gruplarda antiviral profilaksi tedavisi alan yoktu. Grup 3'te ankilozan spondilit tanısı ile takip edilen ve infliksimab tedavisi alan bir hastada reaktivasyon gözlendi.

Sonuç: RTX dışı biyolojik ilaç kullanan hastalarda reaktivasyon orta riskli gösterilmektedir. Çalışmamızda reaktivasyon oldukça düşük bir oranda gözlenmiştir. Bununla birlikte hastalar biyolojik ilaç kullanımı öncesi tarama ve tedavi sırasında reaktivasyon açısından dikkatle takip edilmelidir.
SAĞ VENTRİKÜL ÇIKIŞ YOLU REKONSTRÜKSİYONU UYGULANAN FALLOT TETRALOJİLİ OLGULARDA VENTRİKÜL FONKSİYONLARININ DEĞERLENDİRİLMESİ
Authors: DEVECİ Murat , LEVENT R.ertürk , BULUT Mustafa Orhan , ATAY Yüksel
Published: October 2023

Amaç: Fallot tetralojisi (FT) tam onarımı için transanüler yama (TAP) kullanılan olgular ile kapaklı kondüit olarak heterogreft (Contegra®) kullanılan olguların ventrikül fonksiyonlarının ekokardiyografik parametreler kullanılarak karşılaştırılması amaçlanmıştır.

Yöntem: Çalışmaya aynı merkezde opere olmuş ve izlemde olan 1-18 yaş arası çocuklar dâhil edildi. TAP uygulanan 41 olgu ve Contegra kullanılan 23 olgu ile sağlıklı 40 çocukta, konvansiyonel ekokardiyografinin yanında doku Doppler ekokardiyografik (DDE) yöntem kullanıldı.

Bulgular: TAP (6,26±3,35 yıl) ve Contegra (6,19±3,81 yıl) grupları arasında yaş, cinsiyet, vücut kitle indeksi, ortalama operasyon yaşı ve postoperatif izlem süreleri açısından farklılık yoktu. TAPSE z skoru TAP grubunda -1,97±1,36, Contegra grubunda -2,07±0,88 bulundu (p=0,728). Kontrol grubunda ise TAPSE z skoru -0,39±1,13 ölçüldü ve 3 grup arasında fark anlamlı idi (p
HİRSUTİZMLİ TÜRK KADINLARDA YAŞAM KALİTESİNİN DEĞERLENDİRİLMESİ: ÇAPRAZ KESİTSEL ÇALIŞMA
Authors: SARIGÜL GÜDÜK Şükran , KUŞ Sadiye
Published: October 2023

AMAÇ: Hirsutizmin yaşam kalitesi üzerine olumsuz etkisine dair literatürde yayınlanmış çeşitli çalışmalar mevcuttur. Tüylenmenin normal veya kabul edilir düzeyde olması; etnik kökene ve kadının kıl sayısı ve dağılımı açısından ailesel, kültürel ve toplumsal normları algılamasına bağlıdır. Bu nedenle hirsutizmin yaşam kalitesi üzerine etkisi toplumlar arasında farklılık gösterebilir. Çalışmamızın amacı, kliniğimize başvuran hirsutizmli Türk hastalara Dermatolojik Yaşam Kalite İndeksi (DYKİ) anketleri uygulanarak hastaların yaşam kalitelerinin nasıl etkilendiğini araştırmaktır.

YÖNTEM: Modifiye Ferriman-Gallwey (mFG) skorlamasına göre hirsutizm tanısı alan 40 hasta (ortalama yaş: 21.4±6.98, ranj: 16-40 yaş), çalışmaya dahil edildi. Hastalara dermatolojik hastalıkların yaşam kalitesi üzerine etkisini değerlendirmek için geliştirilen DYKİ anketi uygulandı.

BULGULAR: Çalışmaya dahil edilen hirsutizmli 40 hastanın ortalama yaşı 21,4±6,98 idi. (ranj= 16-40 yaş). Sekiz (%20) hasta polikistik over sendromu tanısı almıştı. Hastaların 30’ unda (%56) akne, androgenetik alopesi, sebore, menstrüel düzensizlik ve akantoz nigrikans gibi hiperandrojenemi bulgularından en az bir tanesi mevcuttu. Ortalama DYKİ skoru 8,83± 5,66 (medyan=8, ranj= 0-25), ortalama mFG skoru 17,18±7,64 (medyan 15,5, ranj= 8-36) bulundu. mFG skoru ile DYKİ skoru arasında anlamlı bir ilişki izlenmedi (rs=0,12, p=0,44). Hirsutizmi olan ve olmayan hastaların ortalama DYKİ skorları arasındaki fark anlamlı derecede idi (p
Nöromyelitis Optika ve Multipl Sklerozlu Bireylerde İlk Demiyelinizan Atakta İnflamatuar Belirteçlerin Karşılaştırılması
Authors: BÜNÜL Sena Destan , CANİK Beyza , EFENDİ Hüsnü
Published: October 2023

Amaç:

Bu çalışmanın amacı, nöromyelitis spektrum hastalıkları (NMOSD) ve multipl skleroz (MS) hastalarında ilk akut atak döneminde periferik kan enflamasyon belirteçlerini değerlendirmek ve bu belirteçlerin hastalıklar arasındaki farklılıkları ortaya koymaktır.

Yöntem:

Çalışmaya Kocaeli Üniversitesi Tıp Fakültesi Nöroloji anabilim dalı MS polikliniği tarafından izlenen hastalara ait veriler retrospektif olarak dahil edildi. NMOSD ve MS tanıları 2015 ve 2017 kriterlerine göre konuldu. İlk akut atak döneminde, NLR, PLR, MLR, SII, AISI ve SIRI gibi enflamatuvar parametreler, periferik kan örneklerinden hesaplandı. Hastaların demografik özellikleri ve EDSS skorları kayıt programından alındı.

Bulgular:

Toplam 44 hasta çalışmaya dahil edildi. NMO tanılı hastaların NLR, PLR, SII ve SIRI değerleri, MS hastalarına göre anlamlı derecede yüksekti. Bu sonuçlar, NMOSD ve MS'nin immunpatogenezindeki farklılıkları yansıtabilir.

Sonuç:

NLR, PLR, SII ve SIRI gibi enflamatuvar belirteçlerin NMOSD ve MS ayırıcı tanısında kullanılabileceği ve hastalığın başlangıç dönemindeki enflamatuvar aktiviteyi değerlendirmede önemli bir rol oynayabileceği düşünülmektedir. Bu bulgular, daha büyük ve çok merkezli çalışmalarla doğrulanmalıdır.
Analysis of prevalence of coinfections in patients living with HIV at Campos Gerais region
Authors: Netto Felício de Freitas , Marcondes Israel , Vaccari Nicole , Mansani Fabiana Postiglione , Silva Leticia Fernandes , Donatoni Leonardo Zampiroli
Published: October 2023

The human immunodeficiency virus is characterized by the tropism for the immune system. This study aims to identify the prevalence of coinfections in people living with HIV (PLHIV), which were followed in the Specialized Service in Campos Gerais region. This is a cross-sectional study and a quantitative approach. In decrescent order, the primary coinfections presented by the patients were oral candidiasis (n=100, 14,47%), non-specified herpes (n=45, 6,51%), syphilis (n=2, 0,29%) and viral hepatitis (n=1, 0,14%). The immune system vulnerability of the carrier makes him or her susceptible to coinfections and opportunistic infections. Between the main coinfections encountered in this study, oral candidiasis, non-specified herpes, syphilis and viral hepatitis stand out. There is a notorious variability on the prevalence of coinfections evidenced by epidemiologic studies similar to this, fact which can be explained by the different cultural perceptions around the HIV infection in different Brazilian regions, as well as the populational heterogeneity.
Prevalence of multi drug resistance malaria among patients aged 0 – 14 years attending murtala muhammad specialist hospital Kano State, Nigeria
Authors: Ummukulsum Mustapha  , Ado Shehu  , Attahir Sa’ad Ayuba  , Hayat Gomma  , Saleh Ngaski Garba  , Usman Sunusi Usman  , Bar. Baffa Alasan  , Muftahu Sa’adu  , Fatima Balarabe Garba  , Abba Jidda Harun  , Yunusa A  , Sagir Magaji  , Salihu Abubakar Dauda
Published: October 2023

The Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) is a molecular marker of parasite susceptibility to anti-malarial drugs. This study aimed to evaluate multidrug resistance resistance gene 1 (MDR1) mutation in 0-14years old malaria patients attending Murtala Muhammad Specialist Hospital, Kano, Nigeria. Samples from 100 children with malaria were examined to confirm the malaria parasite density and further genotyped via BigDye (v3.1) terminator cycle sequencing for the presence of two SNPs in pfmdr1on samples with high and moderate parasite densities. All data were analyzed using Pearson Chi square and Fisher’s exact (FE) tests. Of the 100 patients, 57% had low (+) malaria parasite density, 28% had moderate (++) and 15% had high (+++) malaria parasite densities of the 100 samples, 31 samples were successfully amplified and analyzed for the pfmdr1 gene located at codon 86 with amplicon size of 534bp while only 7 samples were successfully amplified for the pfmdr1 gene located at codon 1246.Pfmdr1-N86Y mutation was detected in 1 (3.2%) sample. In addition, only 1 (3.2%) sample with allelic change at 1246Y was detected in mutant pfmdr1gene. The result also showed that sex had no significant association (P = 0.4237) with pfmdr1SNP mutation. However, significant association (P = 0.0043) between the age groups (1 month to 14 years) represented in the study and pfmdr1mutation. The present study suggests that strains of P. falciparum with reduced sensitivity to the artemisinin component of artemisinin-based combination therapy (ACT) exist in Kano state, northern Nigeria. Methods: sample Collection Finger prick filter paper blood samples were collected from patients below the age of 5 years. However, 2 mL of venous blood was drawn using sterile syringe and needle from children aged 6 and 14 years. Safety procedures were adopted in the collection of blood samples by swabbing the area to be sampled with disinfectant and allowing it to dry before collection.
INORT: Biofertilizer based on Inula viscosa L. (Dittrichia viscosa L.), algae and micro-organisms for growth, Fusarium oxysporum defence and water stress resistance of Plumeria frangipani
Authors: Domenico Prisa  , Francesco Attanasio
Published: October 2023

Research objective: In this study, the possibility of using INORT, a biostimulant based on Inula viscosa L. (Dittrichia viscosa L.), algae and microorganisms to improve growth, defence against Fusarium oxysporum and resistance to water stress, on Plumeria frangipani plants grown in open field was evaluated. Materials and Methods: The experiments, started in January 2023, were conducted in the greenhouses of CREA-OF in Pescia (Pt), on Plumeria frangipani plants cvs “California sunset and “Super round”. The plants were grown in open field. The five experimental groups in cultivation were: group without biostimulant (CTRL); group with microrganisms; group with algae; group with Inula viscosa; group with (INORT) (mix Microorganisms + Inula viscosa + Algae).The product INORT was supplied by the Francesco Attanasio farm. On 15 September 2023, plant height, number of leaves, number of branches, total leaf area per plant (mm2), primary root length (mm), aerial and root system biomass were recorded. In addition, plant mortality as a result of Fusarium oxysporum attacks and water stress was assessed in the experiment. Results and Discussion: The experiment showed that the use of the biostimulant based on Inula viscosa, microorganisms and algae (INORT) can indeed significantly improve the vegetative and root growth of Plumeria frangipani plants grown in the open field. Improvements were also found in plant height, number of leaves, number of floral branches, leaf area, vegetative and root biomass and root length at different irrigation frequencies of 3 and 6 days. A very interesting aspect was also the ability of the biostimulant based on Inula viscosa, microorganisms and algae to significantly reduce the incidence of Fusarium oxysporum attacks on leaves. Conclusions: Given the importance of Inula viscosa from a medicinal, pollination and biodiversity point of view, new agricultural experiments are very important as they could allow the development of new biofertiliser products that can be used in organic and sustainable farming systems
Cannabis Conversations: Suggestions for Providers Serving Perinatal Patients
Authors: McManus Jenny , Halwes Madilyn , Abrantes Ana M. , Battle Cynthia L.
Published: October 2023

Major medical organizations have issued statements discouraging cannabis use in the perinatal period to minimize the risk of potential adverse outcomes. However, many pregnant individuals may decide to continue to use cannabis, or they may wish to quit, but have trouble discontinuing, potentially because they use cannabis to alleviate symptoms such as nausea, pain, sleep difficulties, or anxiety. Patients may not feel comfortable disclosing cannabis use or discussing alternatives, due to perceptions of cannabis safety, stigma, fear of legal repercussions, or mistrust in providers. Healthcare providers from diverse specialties interact with perinatal patients who use cannabis, yet guidance for them is limited. In this commentary, we encourage attention to understanding patients’ motivations for cannabis use. We offer general considerations for engaging in conversations with patients on this topic, including using a nonjudgmental, empathetic, and patient-centered approach to care.
Cytotoxic activity of Helianthemum Lippii
Authors: Bensaber Salah M. , Mrema Ibrahim A. , Jaeda Mousa I. , Gbaj Abdul M.
Published: October 2023

Cancer is one of the most prominent human diseases which have stimulated scientific and commercial interest in the discovery of new anticancer agents from natural sources. The current study investigates the cytotoxic activity ofethanolic extracts of Helianthemum lippii used locally for the treatment of cancer using the MTT assay on the HeLa cell line. Helianthemum lippii showed activity comparable to the reference compound Cisplatin. The results justify the use of Helianthemum lippii in traditional treatment of cancer.
Online Seslifoto (OSF) Yöntemiyle Üniversite Öğrencilerinin Tasavvuf Anlayışını Keşfetmek
Authors: TANHAN Abdurrahim , ERİN Abdulvehap
Published: October 2023

Bu çalışmada araştırmacılar, Online Seslifoto (OSF) yöntemiyle Türkiye’de yardım meslekleriyle ilgili bölümlerde (ilahiyat/İslami ilimler, PDR (Psikolojik Danışmanlık ve Rehberlik), sosyal hizmet, hemşirelik, tıp vb.) okuyan öğrenciler ile belirtilen bölümler dışında farklı bölümlerde okuyan üniversite öğrencilerinin tasavvuf konusundaki algılayışlarını kendi biricik perspektiflerinden inceleyerek keşfetmeye çalışmıştır. Araştırmaya toplam 409 üniversite öğrencisi katılmış, yeterli ölçütleri taşımayan anketler çıkarılarak nihai olarak 103 erkek 214 kadın toplam 317 kişi ile veri analizi yapılmıştır. Elde edilen verilerin analizinde Online Yorumlayıcı Fenomenolojik Analizi (OYFA) kullanılmıştır. Tüm katılımcılardan elde edilen temalar doğrultusunda toplam 21 ana tema oluşmuştur. En önemli ana temalar ve oranları şöyle olmuştur; hoşa giden duygular: Huzur, aşk, sevgi (%25,86, n=82), âlemde Allah’ı görme ve O’nunla iletişim, her şeyin bize O’nu hatırlatması, döngü, bizi rabbe ulaştırır (%25,86, n=82), rabbe bağlılık, yakınlık, O’na duyulan sevgi-ilahi aşk, tevekkül, kendini O’na adama, O’nda yok olma (%22,08, n=70), anlam arayışı, ruhi doyum, farkındalık, hassas bir süreç, maneviyat (%19,55, n=62). Genel olarak öğrenciler tasavvufa ilişkin olumlu bir anlayışa ve algıya sahip olup, tasavvufu işlevsel ve derin anlamlar içeren olumlu söz, kavram ve düşüncelerle ifade etmişlerdir. Sonuçlar, ortaya çıkan ana temalar yoluyla karşılaştırılmış, yardım meslekleriyle ilgili bölümlerde okuyan öğrenciler ile diğer bölümlerde okuyan öğrenciler arasındaki farklılıklar ele alınmıştır.
كتب الخطط في مصر حتى نهاية العصر المملوكي
Authors: لويس عيدان بلقيس
Published: October 2023

تعد كتب الخطط فناَ من فنون الكتابة  في التاريخ الإسلامي ، وهي نوع من المصنفات التي سعى جاهدا مؤلفوها ان تكون بمثابة موسوعة تاريخية شاملة صب جل اهتمامهم فيها على إبراز الجوانب المختلفة من تاريخ مصر ولاسيما الجانب العمراني ، فجوهر كتب الخطط يبحث في الخطط والعمران  ولكنه في ذات الوقت يهتم بعرض الأحداث السياسية والعسكرية والعلمية والاجتماعية والاقتصادية. ولم يكتف مؤلفوها بذلك فحسب بل ذكروا وتتبعوا مراحل تطور الخطط و العمارة وما آلت اليه بعد ذلك حتى زمانهم وان ذكر البعض منهم ذلك بصورة مقتضبة
Changes in global, domestic, and stock price as a response to Indonesian CPO export ban: An opening door into a worldwide financial distress
Authors: Wibowo Hadi , Adam Helmi , Fauziah Mega
Published: October 2023

In April 2022, Indonesian government decided to implement a policy to ban crude palm oil (CPO) exports due to the scarcity of cooking oil in domestic market, which was revoked after twenty-one days put into effect. Considering the important contribution of CPO trade particularly to food and consumer goods industries, a sudden cessation of CPO supplies might instigate financial distress across the globe. This research aims to measure changes in global and domestic CPO price as well as stock price of IDX-listed CPO companies in response to the enactment of CPO export ban under the Decree 22/2022. At the first stage, a descriptive measurement is employed to analyze the monthly changes in value for each price variable. At the second stage, the Pearson's correlation coefficient is applied to measure the statistical relationship between two price variables. The result shows that the domestic market responded more quickly with a 16.77% price drop in May 2022 while global price increased slightly by 2.03% due to the shortage of CPO supply. Nonetheless, a sharp decline in global price of 12.57% occurred in June 2021 shortly after the export ban policy lifted. A moderately strong correlation is found between domestic and global price, expressing a quite similar fluctuation trends for both. In relation to the stock price, neither global price nor domestic price is significantly correlated with. Notwithstanding, both variables are not significantly correlated with the stock price. Stock price shows a rapid return when the CPO trading reopened. This research may contribute to the development of science in economic and financial risk as well as to the government in making future CPO trade policies. As a relatively new issue, there is no similar scientific study to this research found which can be counted a novelty.
The crime of genocide, the stages of its implementation and prevention of the genocide of Anfal and the Yazidi Kurds, for example
Authors: Jamal Mohammed Amin Roshna
Published: October 2023

This research entitled (Genocide, Stages of Implementation and Prevention. Genocide of Anfal and Yazidi Kurds as Examples), attempts to present the concept of genocide as one of the most serious crimes against humanity, committed by oppressive regimes and extremist parties with the intent to destroy, in whole or in part, a national, ethnical, racial or religious group. This paper presents the process of genocide and its stages of implementation based on the theory of international genocide expert Gregory H. Stanton and shows the most important policies and mechanisms of genocide against the Kurdish people in Iraqi Kurdistan and in the region. This paper also attempts to discuss the international efforts to combat the crime of genocide, especially by the United Nations, as well as the most important mechanisms and measures that can be followed to prevent the occurrence or repetition of genocide. This study examines two examples of genocide against the Kurdish people, namely the Anfal genocide against the Kurdish people in 1988 in Iraqi Kurdistan by the Baath regime and the genocide of the Yezidi Kurds in Sinjar in 2014 by of the Islamic State
The Origin of Su Embroidery
Authors: Xu Shuai , Cheng Longdi , Liu Yunying , Lian Youping
Published: October 2023

The connotations of Su embroidery have been enriched chronically. Su embroidery was recognized as a speciality of a specific geographical site when it was first taken as an art of style. Later both the place it was produced and the style of the products affected the evaluation of the embroidery. The technique of the Su embroidery was earlier recognized than its fame known as “Su Xiu” in Chinese. The recognition of its technique resulted from man’s esthetic need and the production of the needed instruments like thread, needle, fabric and dye. Thus the system of the techniques was formed between the middle and late period of Liangzhu Culture (28-20th century BC) and the Spring and Autumn Period and the Warring States Period (557-532 BC). The development of technology, the need of the market, and the influence of culture altogether brought out the name “Su Xiu” in the Zhengde period of the Ming Dynasty (1506-1521).
On Han Fei Tzu’s Thought of Crime Prevention
Authors: Jiang Zongyan
Published: October 2023

Crime prevention refers to the active intervention before the occurrence of crimes. Han Fei Tzu, a legalist during the pre-Qin period, viewed the suppression of criminal motives as the core of crime prevention, and brought out a series of measures to prevent crimes. In this paper, the author summarized his thoughts on crime prevention by analyzing his views on human nature, the causes of crimes, and crime prevention.
Effects of Water Level on Growth and Survival of Clarias gariepinus (Burchell, 1822) Fingerlings
Authors: Usman A
Published: October 2023

This study evaluated and compared growth performance and survival of Clarias gariepinus fingerlings cultured in different water level. The water level used was 0.8m (T1), 1.0m (T2) and 1.2m (T3). 120 C. gariepinus fingerlings of initial mean weight 3.45±0.00-3.75±0.00g was fed for 60 days twice a day (morning and evening) with commercial (Coppens) feed at 5% body weight and weighed fortnightly, the new weights were used to adjust the quantity of offered feed to the fish. Weight gain (WG), specific growth rate (SGR), feed conversion ratio (FCR), survival rate, etc., were determined fortnightly for each treatment. Data resulting from the experiment were subjected to one-way analysis of variance (ANOVA) at (P<0.05) significance level. The results shows that the highest (49.64g) weight gain was recorded in T3 followed by T2 (44.68g), and lowest (43.23g) weight gain of was obtained in T1. There were no significant differences (P< 0.05) among the treatment from one another. The highest (53.30g) final weight was obtained in fish, stocked in T3, followed by T2. The least (46.70g) final weight was recorded in T1. There were no significant differences (P<0.05) between the treatment. The least (1.74) feed conversion ratio was obtained in T2, followed by 1.60 T3, and lowest (1.35) value of feed conversion ratio was recorded in T1. It has been observed that, there was no significant differences (P<0.05) between the treatment. Water quality parameters indicate (Table 3) highest (7.85) pH value was recorded in T2 and the lowest (7.28) pH value was obtained in T1. There were no significant differences (P<0.05) between the treatment. The water temperature was higher (25.75) in T2 while the least (25.670C) was obtained in T3, there was no significant differences (P<0.05) between the treatment respectively. Therefore, it can infer that for optimal survival and growth of C. gariepinus fingerlings should be reared in water depth of 1.2m.
Carleton, Kavanagh and the South Ulster Landscape c. 1800 — 1950
Authors: Duffy P. J.
Published: October 2023

The short stories of William Carleton and the novels and poetry of Patrick Kavanagh are examined for the light they throw on the personality of the south Ulster landscape. Carleton wrote about the region in the prefamine decades; Kavanagh for the years before the second world war. Both writers, therefore, were witness to changes in society and landscape in one of the most formative periods in the making of modem Ireland. Irish geographers might profitably focus their attention on analyses of the sense of place and regional literature in Ireland.