bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Validation of the Use of Immobilized Form of Miramistin
in the Treatment of Advanced Peritonitis
Authors: Sukovatykh Boris Semenovich , Zatolokina Maria Alekseevna , Mosolova Anastasiya Viktorovna
Published: January 2021

Introduction. Mortality in generalized peritonitis ranges from 16% to 30%.The aim of research was to experimentally study the effect of the immobilized form of 0.01% miramistin on the basis of sodium salt of carboxymethylcellulose on the course of the inflammatory process in generalized purulent peritonitis.Materials and methods. The experimental study included 288 male Wistar rats, divided into 3 groups, 96 animals each. Animals of the 1st group (control) were exposed to laparotomy and lavage of the abdominal cavity with saline under aseptic conditions 24 hours after the introduction of fecal suspension into the abdominal cavity. Simultaneously, animals of the 2nd group (comparison) underwent a thorough sanitation of the abdominal cavity with saline with removal of purulent effusion and fibrin films at the first stage, and at the second stage, they were injected 5 ml of an aqueous solution of 0.01% miramistin. In animals of the 3rd (experimental) group, 5 ml of 0.01% miramistin gel was evenly distributed over the entire surface of the peritoneum after laparotomy and sanitation of the abdominal cavity with saline solution. The anti-inflammatory activity of the dosage forms was assessed by the dynamics of leukocytosis and the leukocyte index of intoxication, and the anti-inflammatory activity was assessed by the dynamics of the number of microorganisms in the abdominal exudate. The lethality of animals in each group was estimated. The following areas were taken for histological examination: small and large intestine, parietal peritoneum, pancreas, liver.Results. The anti-inflammatory activity of the immobilized form of 0.01% miramistin on the basis of sodium carboxymethylcellulose was superior to the aqueous solution of miramistin 0.01% on the 1st day - 1.3 times, on the 3rd day - 1.6 times, on the 7th day - 1.5 times. Antimicrobial activity in animals of the experimental group was 1.3 times higher on the 1st day, 1.9 times higher on the 3rd day, and 1.7 times higher on the 7th day than in the comparison group. The mortality rate in animals of the experimental group was 1.5 times lower on the 1st day, and 1.4 times lower on the 3rd and 7th days than in animals of the comparison group. On the first day, the morphological picture of peritonitis in animals of the experimental and comparison groups had no significant differences. On the 3rd day in animals of the comparison group, the inflammatory process in the abdominal cavity was pronounced, and in the experimental group, the intensity of peritonitis began to decrease, and by the 7th day it was completely eliminated.Conclusion. The results of the study allow recommending the use of the immobilized form of 0.01% miramistin based on sodium carboxymethylcellulose in the treatment of generalized peritonitis.
Collagen and Use Its in the Treatment of Wounds
Authors: Ostroushko Anton Petrovich , Andreev Alexander Alexeyevich , Laptiyova Anastasiya Yurievna , Glukhov Alexander Anatolievich
Published: January 2021

Wounds take the main places of among surgical diseases, and the problem of developing new methods of their treatment remains relevant today. In recent years, the use of collagen has been widely used in the treatment of wounds. Collagen modulates the flow of fluid from the wound, facilitates the migration of fibroblasts and the formation of microvessels, helps in the synthesis of neodermal collagen matrices, forms complexes with biologically active substances and minimizes the formation of scars.Currently, collagen is used in the treatment of soft tissue wounds in the form of several pharmaceutical forms. Collagen sponges are used in the treatment of thermal and mechanical wounds, for local delivery of medicines. Collagen gels can be used for injections. Collagen can also be implemented in the form of a collagen shield. There are also collagen granules that have been developed for various compounds.Thus, the use of collagen is promising in the development of new medicinal preparation. However, for a wider disclosure of its clinical potential, it is necessary to thoroughly study all types of collagen and reveal their role at different stages of soft tissue repair.
Accurate Measurement of Surface Areas of Anatomical Structures Including Areas with an Irregular Relief: a Modern Solution to the Problem
Authors: Воробьев A. A. , Makedonova Yu. A. , Solov'ev A. O. , D'yachenko D. Yu. , Bagrii E. G. , Ageeva Yu. V. , Gritsenko I. A.
Published: January 2021

Relevance. The currently available methods for measuring anatomical areas with irregular relief do not claim to be accurate and easy to use.

The aim of the study was to develop a method for measuring the surface area of an anatomical region (substructure) with an irregular relief.

Material and methods. There was developed an option to measure the surface area of an anatomical region (substructure) with a complex relief in patients with pathology of the maxillofacial region and perineum using realistic 3D modeling.

Results. The principle of the developed method is that, firstly, it is necessary to determine the patient's "zone of interest", where it is planned to measure the surface area; after that, digital photographs of the defined area are taken to obtain a sufficient number of images from the maximum number of available angles using a template with predefined dimensions for scaling. Then the obtained photographs are processed in the program for the 3D model reconstruction, and a realistic 3D model that correctly repeats the relief of the "zone of interest" and guarantees measurements of the surface area taking into account all its individual features is obtained. The method has been tested in obstetrics and gynecology, dentistry, maxillofacial surgery.

Conclusion. This technique has been proved to be simple, accessible, fast, highly accurate in measuring the area of anatomical regions with complex relief. At the same time, the investigated object does not need fixation and prolonged immobility. A digital optical device is used contactless, the fact being significant in situations where it is necessary to comply with the rules of asepsis and antisepsis.
Vulcanização com Produtos Naturais: Uma análise através da Modelagem Molecular
Authors: Da Costa Helson Moreira , Dutra Ramos Valéria
Published: January 2021

Nesta investigação, os dados experimentais para a vulcanização da borracha natural (NR) e do copolímero de estireno-butadieno (SBR) com óleos vegetais de amendoim, coco e linhaça, além da cera de abelha, foram validados através da modelagem molecular das principais reações do processo. O método semiempírico AM1 (Austin Model 1) permitiu comprovar que a redução da dureza, associada à solubilidade na matriz elastomérica, é o fator que permite que ácidos graxos insaturados de 12 ou mais átomos de carbono ajam como ativadores em associação com o óxido de zinco. Porém, o impedimento estérico torna o ácido lignocérico, presente na cera de abelha, um ativador de baixo desempenho. Para os ácidos graxos insaturados de 18 carbonos, presentes nos óleos de amendoim e linhaça, as insaturações aumentam a reatividade das espécies geradas na vulcanização. No entanto, tal alteração de natureza produz efeito adverso, pois provavelmente induz reações laterais que comprometem o papel ativador dos óleos.
3D Bioprinting: a review of materials, processes and bioink properties
Authors: Fontes Anna Beatriz , Marcomini Raphael Fortes
Published: January 2021

Bioimpressão 3D é um método de manufatura aditiva para engenharia de scaffolds usados como modelos para adesão celular, crescimento celular e subsequente formação de tecidos. Um dos biomateriais mais utilizados para biotintas é o hidrogel devido às suas propriedades adaptáveis que facilitam o processo de bioimpressão 3D e fornecem ambientes extracelulares favoráveis para várias funções celulares. A bioimpressão 3D pode ser dividida em técnicas baseadas em extrusão, jato de tinta ou impressão assistida a laser. Um dos maiores desafios na bioimpressão 3D é sua otimização, que depende da complexidade da estrutura 3D, das propriedades dos materiais e do desenvolvimento da biotinta para a “janela de bioimpressão”. Este trabalho pretende revisar o estado da arte das classificações e materiais componentes de hidrogéis, a física envolvida em técnicas de bioimpressão e as propriedades que afetam printabilidade e viabilidade celular.
Productivity enhancement of stepped solar still integrated MEMS light sensors for solar tracker
Authors: Muftah Ali. F.
Published: January 2021

Water is life, and the threat of unsustainable means of potable water supplies has led to the reviews of various renewable energy sources to create a cleaner and more efficient solution for potable water supply. The aim of this study is to present a way in which the efficiency of stepped solar still can be increased. It is to increase the efficiency of solar still by increasing the amount of time that the solar still is directly perpendicular to the sunlight. The Micro-Electro-Mechanical Systems (MEMS) light sensors for solar tracking are used to enhance the productivity. The results obtained indicate that the use of MEMS light sensors for solar tracking are used to makes a solar still to be predictable and it equally increases its efficiency in terms of distillate yield and overall performance.
Agradecimento a pareceristas do v. 16, n. 2, dezembro 2020
Authors: Albagli Sarita , Os Editores
Published: January 2021

Agradecimento
Clinical results of Nuss procedure for pectus excavatum in different age groups
Authors: AKKUŞ Murat , APAYDIN Tuba
Published: January 2021

Aim: In 1998, Donald Nuss suggested the insertion of a metal bar behind the sternum for pectus excavatum as a minimally invasive technique. However, data regarding the relation between the age of the patient and clinical results of repair is limited. Aim of this study is to compare the clinical results of Nuss surgery for pectus excavatum in different age groups, to point out the optimal range of age for this procedure.

Material and Methods: From February 2012 to January 2020, data regarding 140 patients have been treated with Nuss surgery. We classified patients into three groups: patients younger than 15 years (group A), patients between 15 and 20 years (group B); and patients older than 20 years up to 40 years (group C) retrospectively. We evaluated patients' demographics, and compared results of surgery, duration of hospitalization and complication rates.

Results: One hundred ten patients were male and 30 were female. Male patients, clinical symptomatic patients with dyspnea in the preoperative period were seen more frequently in patients with older age, and each were statistically significant (p:0.003). In the early 30-day postoperative period, no mortality was observed. The most frequent postoperative complications were observed in group C (40,9%), followed by group B (18,2%) and group A (9,6%)(p:0.007). In logistic regression analysis, postoperative complications increased significantly in patients older than 20 years (p:0.003). Brace therapy was performed for 2 cases in Group A for recurrence after bar removal which occurred in adolescant period.

Conclusion: Nuss procedure can be recommended with low complication rates, short term hospitalization and high grade of success. Although the childhood period seems to be more suitable regarding the complications, surgery can be preferred with low recurrence rates in adolescant period.
Challenges and prospects for developing genetic resistance in common wheat against stem rust in Western Siberia
Authors: Kelbin V. N. , Skolotneva E. S. , Salina E. A.
Published: January 2021

Current studies on bread wheat resistance to stem rust have two main subjects: complex analysis for resistance of bread wheat germplasm using molecular markers, field screening and laboratory tests against samples of different fungal populations, and searching for sources and donors of new genes and gene loci, including cultivated and wild relatives of wheat. To achieve adequate genetic control of the disease, an integral approach is important, incorporating both data on sources of resistance and relevant information on pathogenic populations existing in the region, their race composition and dynamics of virulence genes. The analysis of experimental data on field screening of bread wheat varieties from the CIMMYT nursery germplasm for stem rust resistance in the Omsk and Novosibirsk regions, together with laboratory testing of infection samples on the international set of wheat differential lines, suggests that a separate “Asian” population of Puccinia graminis f. sp. tritici exists in Western Siberia and the Altai Territory. Wheat resistance genes Sr2, Sr6Ai#2, Sr24, Sr25, Sr26, Sr31, Sr39, Sr40, Sr44, and Sr57 are of practical interest for advanced wheat breeding programs for stem rust immunity in Western Siberia. This review provides an analysis of the gene sources that remain effective against the West Siberian population of P. graminis, in order to facilitate the initial stage of selection of breeding material to develop a stable genotype by gene pyramiding. The basic requirements for conducting a phytopathological test of breeding material are presented. A list of molecular markers for the mentioned resistance genes, both widely used in marker-assisted selection and requiring verification, has been compiled.
Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus
Authors: Ershov N. I. , Maslov D. E. , Bondar N. P.
Published: January 2021

The parasitic flatworm Opisthorchis felineus is one of the causative agents of opisthorchiasis in humans. Recently, we assembled the O. felineus genome, but the correct genome annotation by means of standard methods was hampered by the presence of spliced leader trans-splicing (SLTS). As a result of SLTS, the original 5’-end (outron) of the transcripts is replaced by a short spliced leader sequence donated from a specialized SL RNA. SLTS is involved in the RNA processing of more than half of O. felineus genes, making it hard to determine the structure of outrons and bona fide transcription start sites of the corresponding genes and operons, being based solely on mRNA-seq data. In the current study, we tested various experimental approaches for identifying the sequences of outrons in O. felineus using massive parallel sequencing. Two of them were developed by us for targeted sequencing of already processed branched outrons. One was based on sequence-specific reverse transcription from the SL intron toward the 5’-end of the Y-branched outron. The other used outron hybridization with an immobilized single-stranded DNA probe complementary to the SL intron. Additionally, two approaches to the sequencing of rRNA-depleted total RNA were used, allowing the identification of a wider range of transcripts compared to mRNAseq. One is based on the enzymatic elimination of overrepresented cDNAs, the other utilizes exonucleolytic degradation of uncapped RNA by Terminator enzyme. By using the outron-targeting methods, we were not able to obtain the enrichment of RNA preparations by processed outrons, which is most likely indicative of a rapid turnover of these trans-splicing intermediate products. Of the two rRNA depletion methods, a method based on the enzymatic normalization of cDNA (Zymo-Seq RiboFree) showed high efficiency. Compared to mRNA-seq, it provides an approximately twofold increase in the fraction of reads originating from outrons and introns. The results suggest that unprocessed nascent transcripts are the main source of outron sequences in the RNA pool of O. felineus.
Evaluation of Blood Lactate Concentration in Dogs Receiving Whole Blood Transfusion
Authors: Zakarevičiūtė B. , Juodžentė D. , Karvelienė B. , Čechovičienė S. , Riškevičienė V.
Published: January 2021

Background: A blood transfusion is a routine, life-saving procedure used to replace blood cells or blood products. The current study was aimed to assess whether the blood lactate concentration has a prognostic value of successful blood transfusion. Methods: During the period 2018-2019 group I dogs (n=19) received whole blood transfusion and twenty dogs were assigned to the control group (group II). Blood samples in group I were obtained from cephalic vein before blood transfusion (T0), then after it was finished (4hr±20 min) (T1) and 24hr±20 min after the T0 (T2). Result: The level of blood lactate reached the normal level after blood transfusion in T1 and T2. The clearance of lactate had a moderate negative correlation with packed cell volume (PCV) and red blood cells (RBC). There was no significant correlation between survival rate and blood lactate level. The survivals 24hr after transfusion (T2) had five times higher count of reticulocytes (RETIC) then non-survivals. Serial blood lactate measurement can improve the prediction of successful blood transfusion and it is useful in monitoring the patient status 24hr post blood transfusion, but it doesn’t have the predictive value of survival.
Estudo exploratório sobre a causalidade psíquica em paciente com queixa de zumbido crônico
Authors: Schirmer Bruna de Franceschi , Moro Mendes Adriane Maria , Andreola Maria Tereza
Published: January 2021

Introdução: A patologia, tanto em aspecto psíquico, quanto somático é um reflexo da vida do indivíduo; é a manifestação externa da sua vida interior, que na maioria das vezes são contraditórias. Para que ocorra a cura de determinados sintomas e doenças expressados de modo físico é imprescindível fazer a busca dos fatores etiológicos também na esfera psíquica. Objetivo: Descrever um caso clínico, com queixa de zumbido crônico, sem nenhuma alteração orgânica. Através de anamnese linguística, biografia histórica, Teste dos seis desenhos (T6D) e análise onírica buscou-se verificar uma correspondência entre sintoma e atividade psíquica. Metodologia: O trabalho foi composto por quatro encontros, estruturados do seguinte modo: 1) Anamnese Linguística e biografia histórica e Audiometria Tonal Liminar; 2) conversa para o aprofundando da Anamnese Linguística histórica e relato de um sonho; 3) relato de mais um sonho; 4) realização do T6D. Tanto os sonhos quanto o teste dos Seis Desenhos (T6D) foram analisados segundo a metodologia da escola ontopsicológica para análise das imagens: 1) natureza causal do símbolo. 2) Efetividade funcional para o sujeito. 3) Critério semântico. Resultados: os achados sugerem, Tendência a Autossabotagem, indicando frustração, estagnação e regressão. Conclusão: acredita-se que o zumbido possa ter ligação com as manifestações psíquicas demostradas, pois quando o impulso de energia vital não possui mais função de ida e volta, o sujeito vivencia o mal. Principalmente, nos casos em que o sujeito deveria e tinha possibilidade de agir, não o faz.
Uso da ferramenta Kodular no ensino de matemática para a educação básica
Authors: Nunes Felipe Becker , Karkow Hercules Affonso
Published: January 2021

Este trabalho visou realizar um experimento de forma qualitativa com uma docente da área de Matemática e sua turma do 2º ano do Ensino Médio. O intuito foi complementar a didática das aulas e aproximarem-se da realidade social atual com relação ao uso da tecnologia com a utilização da ferramenta de desenvolvimento de projetos mobile chamada Kodular, como estudo de caso. Para a coleta de dados, foram aplicados questionários com perguntas objetivas e dissertativas tanto para a turma, quando para um grupo de professores para saber a opinião deles sobre o uso de ferramentas tecnológicas nas escolas, e entrevistas com a turma de discentes e a docente. E como resultados, em linhas gerais, após o uso da ferramenta, os alunos se mostraram motivados, com um índice maior de atenção para com os conteúdos da disciplina, inferindo assim que a ferramenta complementa seu processo de aprendizagem em sala de aula e de forma resumida, é algo que foge da rotina monótona realizada em algumas escolas, se tornando algo divertido e complementar.
As redes de inovação sob a premissa do comunitarismo: ambientes para geração tecnológica na universidade
Authors: Grunevald Isabel , Schmidt João Pedro
Published: January 2021

Este trabalho apresenta um olhar sobre a criação de novas tecnologias, caracterizadas através da inovação tecnológica na atual sociedade do conhecimento, observando-se se tal alcance está alinhado aos preceitos fundamentais da teoria filosófica-política do comunitarismo responsivo. O comunitarismo destaca o equilíbrio entre o Estado-comunidade-mercado, como modelo alternativo a dicotomia público/privado. Trata-se de um estudo inicial, no qual parte-se do pressuposto que a inovação tecnológica é fruto de um processo de construção coletiva, e não decorrendo de iniciativas individuais. A base teórica do presente texto no que tange ao comunitarismo está inclinada às obras de Amitai Etzioni e o método é o bibliográfico.
Nutritional and anti-methanogenic potentials of macroalgae for ruminants
Authors:   Nord University, Norway, Pandey Deepak , Mansouryar Morteza ,   University of Copenhagen, Denmark, Novoa-Garrido Margarita ,   Nord University, Norway, Næss Geir ,   Nord University, Norway, Kiron Viswanath ,   Nord University, Norway, Hansen Hanne Helene ,   University of Copenhagen, Denmark, Nielsen Mette Olaf ,   Aarhus University, Denmark, Khanal Prabhat ,   Nord University, Norway
Published: January 2021

The livestock production sector is facing challenges to find alternative feed resources and nutritional strategies to mitigate enteric methane (CH4) emissions from ruminants. Recently, marine macroalgae have emerged as potential anti-methanogenic feed ingredients due to their ability to suppress enteric CH4 production in ruminants. The anti-methanogenic properties of macroalgae have been ascribed to the contents of secondary metabolites, such as halogenated compounds e.g., bromoform in red species, and polyphenols or isoprenoids in brown species. These compounds may suppress methanogenesis by inhibiting the growth and activity of methanogens or by altering rumen fermentation pathways and the patterns of volatile fatty acids production. On the other hand, the anti-methanogenic macroalgae, particularly when added to diets in large amounts, are known to reduce animal performance, due to the presence of special and poorly degradable carbohydrates. Thus, finding a proper balance between the abilities to reduce CH4 emissions and sustain animal performance is important.
Literatura como elemento de estímulo ao desenvolvimento de soft skills no ensino de administração: o Projeto Corpus Literário (PCL)
Authors: Batista Natalia Bousquet , Pereira Patrick Dos Santos , Santa Rita Ana Carolina Rocha
Published: January 2021

A literatura é um meio agradável e rico para estudar e pensar a natureza humana. A administração, como ciência social aplicada, é capaz de traçar paralelos a partir da abstração de conceitos no que tange o entendimento da natureza humana e suas relações. O Projeto Corpus Literário (PCL) é um projeto de leitura semestral de livros complementares. Há um grupo de professores que desenvolve agenda de encontros e discussões em rodas de conversa, seminários e palestras, estimulando a participação ativa dos alunos. O caráter das discussões em torno da obra é literário e interdisciplinar. Temas como liderança, estratégia, conflitos, poder, processo de trabalho, questões éticas, dentre outros, estão presentes na sociedade e na dinâmica empresarial e podem ser representadas na literatura e gerar reflexões para o ensino da administração, oferecendo uma apreensão primeira de fenômenos sociais.Através do PCL, a Universidade constrói um espaço favorável ao desenvolvimento crítico, criativoe reflexivo dos alunos ao desenvolver soft skills no ensino de administração, contribuindo para aconsolidação de uma compreensão mais humanística da realidade e pensando a interdisciplinaridadee as relações de ensino, pesquisa e extensão da instituição.
¿Rehabilitar patrimonio o escolarizar a la población? Gasto público en la Sevilla de mediados del siglo XIX
Authors: Daza Sierra Antonio J.
Published: January 2021

Este artículo reflexiona sobre la provisión de servicios educativos públicos en la ciudad de Sevilla durante la Década Moderada, poniendo de manifiesto la contradicción entre la legislación nacional y la práctica local en la creación y puesta en funcionamiento de las escuelas públicas. El análisis de la documentación municipal demuestra cómo las obligaciones de los Ayuntamientos crecieron acompañadas de restricciones presupuestarias. Las decisiones de las autoridades locales, en última instancia, beneficiaron los intereses de las élites urbanas, y los escasos fondos destinados a la educación primaria se desviaron hacia la rehabilitación de edificios y el establecimiento de centros de enseñanza secundaria, en perjuicio de las necesidades de las clases populares y contraviniendo las normativas nacionales.
Sexualidad y religión en el tardofranquismo. La recepción de la Humanae Vitae en España y la crisis de autoridad de la iglesia
Authors: García Fernández Mónica
Published: January 2021

El objetivo de este artículo es analizar el contexto en el que se publicó la encíclica Humanae vitae (1968) de Pablo VI y su recepción en España. Se trata de explorar sus antecedentes e impacto en el marco del Concilio Vaticano II y también del llamado “desenganche” de la Iglesia en el tardofranquismo. La controversia que se generó cuestionó la propia autoridad moral de la Iglesia. Además, se inserta en un contexto en el que se estaba produciendo una importante transformación en la concepción católica de la sexualidad, ligada asimismo a un vivo debate sobre el control de la natalidad en el que la popularización de la “píldora” tuvo gran peso.
1969-1977. La construcción de la imagen de la monarquía española a través de las encuestas
Authors: Magallón Rosa Raúl
Published: January 2021

El objetivo de este estudio es analizar el papel de las encuestas censuradas y silenciadas en la transición española sobre Juan Carlos de Borbón y la monarquía española entre 1969 y 1977. En este trabajo se analizan las encuestas nunca hechas públicas por el Instituto de Opinión Pública -renombrado CIS en 1977- y Foessa, además de los estudios de opinión realizados a partir de 1976 por Gallup España. Lo que muestran los distintos sondeos es que ni siquiera una dictadura que ya duraba 30 años había conseguido el consenso social y cultural necesario para que legitimación social y legal fueran coincidentes.
¿Todos los partidos?: partidos ilegales y las elecciones de 1977
Authors: Senent Sansegundo Juan Carlos
Published: January 2021

Las elecciones de 1977 fueron las primeras elecciones democráticas que se celebraban en España desde febrero 1936. Pero en ellas, no todos los partidos políticos fueron legales. Tratamos de responder a algunas preguntas que nos hemos hecho: ¿Por qué no fueron legalizados? ¿De qué partidos políticos de trata? ¿No pudieron presentarse a las elecciones?  Nos adentramos en esta cuestión, poco tratada en la historiografía especializada y que supone una situación anómala en el proceso de cambio político que se estaba llevando a cabo en aquellos años en España, a través, sobre todo, de fuentes hemerográficas, aunque también de archivo y con la consulta de la bibliografía necesaria, para responder a las cuestiones planteadas.
Julián Chaves Palacios, José Giral Pereira. Su vida y su tiempo en la España del siglo XX, Barcelona, Anthropos, 2019, 462 páginas
Authors: Sánchez Recio Glicerio
Published: January 2021

Reseña
Necessidade de estrutura de compliance nas instituições financeiras
Authors: Nakamura Elaine Aparecida Maruyama Vieira , Nakamura Wilson Toshiro , Jones Graciela Dias Coelho
Published: January 2021

A área de Compliance é muito importante, principalmente para Instituições Financeiras, sendo responsável por instituir controles, regras, procedimentos preventivos em atendimento aos regulamentos e legislações nacionais e internacionais. Essa área representa uma extensão nas Instituições, em atendimento a legislação de prevenção à lavagem de dinheiro (monitoramento das movimentações financeiras), e tem forte importância como pilar de Governança Corporativa. Baseado na experiência de 13 anos, na estruturação das responsabilidades de uma área de Compliance, por meio de participação direta em uma Instituição Financeira, o objetivo desse relato técnico é descrever de forma aplicada a evolução da área de Compliance, sua importância, sua abrangência, as contribuições da existência de adequada estrutura às necessidades da Instituição e do mercado e as consequências de não ter a área. Tudo o que é relatado confirma que organizações necessariamente precisam buscar o compliance, como meio de fortalecer sua posição no mercado, e encarar a ética não só como uma forma de ação conveniente. Após anos de experiência na área, desenvolvendo-a e estruturando-a, conclui-se que compliance é um braço dos Órgãos Reguladores junto a Administração, no que se refere à segurança, respeito à normas e controles e à busca da conformidade por meio da ética.
Análise estrutural e longitudinal sobre capacidades dinâmicas em agências de publicidade e em mídias sociais
Authors: Simi dos Santos Silvia Spagnol , Begnini Sérgio , Carvalho Carlos Eduardo , Oro Ieda Margarete
Published: January 2021

Este trabalho contribui para a compreensão sobre estudos a respeito de capacidades dinâmicas aplicadas a agências de publicidade e em mídias sociais. O objetivo é analisar a configuração dos trabalhos publicados e sistematizar os procedimentos técnicos de pesquisa utilizados, assim como enumerar e quantificar os principais autores, journals, bases de dados e ano das publicações. Como metodologia, a investigação utiliza de uma revisão sistemática de artigos publicados entre 2008 e 2017, com uso de algumas técnicas bibliométricas. No total, foram analisados 244 artigos. Esta revisão de literatura integrativa das CD acrescenta à categorização da literatura, relaciona a pesquisa de mídias sociais e agências de publicidade às CD e fornece orientações favoráveis para pesquisas futuras. O estudo aponta para a tendência de publicações qualitativas com foco em mídias sociais, consequentemente, os resultados sugerem a necessidade de mais investigações sobre esse objeto de estudo pela ascendência das mídias sociais.
Uma análise do desempenho dos estados nordestinos na política de ciência, tecnologia e inovação entre 2000 e 2015
Authors: Gonçalves Bruno Setton , De Santana José Ricardo
Published: January 2021

O presente artigo aborda o papel dos investimentos públicos estaduais em Ciência, Tecnologia e Inovação (CTI) na formação da base cientifica e tecnológica do Nordeste. Para tal foi criado um indicador para medir o desempenho na execução da política de CTI, durante o período de 2000 a 2015. Adotou-se um modelo lógico dedutivo, que estabelece uma ordem de causalidade entre as variáveis. Com isso foi possível posicionar os estados do Nordeste por nível de investimentos públicos em CTI, o ordenamento dos estados em um ranking de desempenho possibilitou identifica três blocos distintos quanto ao tamanho e desempenho da base científica e tecnológica dos estados nordestinos.
Analysis of the relationship between physical infrastructure and the networks of inter-relationships in the Brazilian technological parks
Authors: Roldan Lucas Bonacina , Veiga Alexandre Bom , Hansen Peter Bent , Bencke Fernando Fantoni
Published: January 2021

No atual ambiente competitivo, a inovação se tornou importante na busca de diferenciais. As interações entre as empresas, e entre as empresas e universidades são consideradas ações importantes para a inovação. Parques tecnológicos são ambientes projetados para aproximar empresas e universidades. Este artigo tem como objetivo analisar a relação entre a adequação das infraestruturas físicas dos parques tecnológicos e as interações nas redes de relacionamentos entre as empresas residentes, e entre as empresas e as universidades. Para tanto, um modelo teórico foi elaborado e testado quantitativamente por meio de modelagem de equações estruturais, analisado a partir de uma amostra válida de 189 empresas residentes em parques tecnológicos brasileiros. Os resultados demonstram relações significativas sobre a influência da infraestrutura física dos parques tecnológicos sobre as interações entre as empresas residentes e entre as empresas e universidades, e a importância de uma infraestrutura física adequada para gerar interação à inovação.
Attitudes towards internet use: development and proposal of a measurement scale
Authors: Mota Flavio Perazzo Barbosa
Published: January 2021

Conceitualmente, atitudes em relação ao uso Internet representam a avaliação individual em relação ao uso dessa tecnologia, constituindo elementos importantes para entender o uso e as atividades realizadas no ambiente virtual. Os propósitos desse estudo foram revisar sistematicamente o conceito e as escalas utilizadas para medir o construto, bem como propor um instrumento de medição de natureza multidisciplinar. Por meio do estudo sistemático da literatura acadêmica internacional foi possível definir o construto e identificar a tradição de mensuração. Com isso, foi proposto e validado um instrumento com nove afirmações para averiguação por meio de uma escala de verificação do tipo Likert. Tal iniciativa permitiu categorizar fatores atitudinais em uma dimensão de apreciação e outra de aversão. Os resultados da pesquisa contribuem para entendimento do construto, servindo tanto para aplicações no setor público quanto no setor privado.
Accurate radial basis functions technique for competitive and efficient solutions of non-linear Black-Scholes equations
Authors: Pinto Marques Vinícius Magalhães , Santos Gisele Tessari , Fortes Mauri
Published: January 2021

ABSTRACTObjective: This article aims to solve the non-linear Black Scholes (BS) equation for European call options using Radial Basis Function (RBF) Multi-Quadratic (MQ) Method.Methodology / Approach: This work uses the MQ RBF method applied to the solution of two complex models of nonlinear BS equation for prices of European call options with modified volatility. Linear BS models are also solved to visualize the effects of modified volatility.  Additionally, an adaptive scheme is implemented in time based on the Runge-Kutta-Fehlberg (RKF) method.
Genome Wide Identification of Cotton C-Repeat Binding Factor (CBF) and Overexpression of Gthu17439 (GthCBF4) Gene Confer Cold Stress Tolerance in Arabidopsis Thaliana
Authors: Liu Jiangna , Magwanga Richard , Xu Yanchao , Wei Tingting , Zheng Jie , Hou Yuqing , Wang Yuhong , Agong Stephen , Wang Kunbo , Zhou Zhongli , Cai Xiaoyan , Liu Fang
Published: January 2021

Low temperature is a common biological abiotic stress in major cotton growing areas. Cold stress significantly affects the growth, yield and yield quality of cotton. Therefore, it is important to develop a more robust and cold stress tolerant cotton germplasms. Climate change and erratic climatic condition, plants have evolved various survival mechanisms, one of which induction of various stress responsive transcriptome factors, such as the C-repeat binding factor GthCBF4, which have been found to enhance cold tolerance in various plants. In this study detailed evaluation of the cotton C-repeat binding factor has been carried out. A total of29, 28, 25, 21, 30, 26 and 15 proteins encoded by the C-repeat binding factor were identified in G. herbaceum, G. arboreum, G. thurberi, G. raimondii, G. turneri, G. longicalyx and G. australe, respectively. Phylogeny evaluation revealed that the proteins were grouped into seven clades, with clade 1 and 6 being the largest. Moreover, majority of the proteins encoded by the genes were predicted to be located within. the nucleus, while some are distributed in other parts of the cell. Based on the transcriptome and RT-qPCR analysis, Gthu17439 (GthCBF4) was highly upregulated and was further validated through forward genetics. The Gthu17439 (GthCBF4) overexpressed plants showed a significantly tolerance to cold stress, with higher growth vigour compared to the wild types. The results showed that the Gthu17439 (GthCBF4) could be playing a significant role in enhancing cold stress tolerance in cotton and can be further exploited in developing a more cold stress tolerance cotton germplasm
Effect of Pr6O11 on the Microstructures and Mechanical Properties of High-Strength Steel Weld Metal
Authors: Zhang Tianli , Yu Hang , Li Shiliang , Wang Weiguang , Wu Wen , Chen Haoxin , Chen Yu
Published: January 2021

The effect of rare earth Pr6O11 on the microstructure and mechanical properties of high-strength steel weld metal was investigated by optical microscopy, scanning electron microscopy and mechanical testing. Three different contents of Pr6O11 were added to the flux-cored wires. The results showed that the addition of 1% Pr6O11 can promote the refinement and spheroidization of inclusions, refine the grains, form acicular ferrites, and significantly improve the toughness of weld metal. The addition of Pr6O11 promoted the formation of rare earth composite inclusions and acicular ferrites in the weld metal, refined the lath microstructure, inhibited the formation of martensite and bainite. The crack formation mode changed from the boundary cracking of the bainite clusters caused by the surface shear stress to the surface shear stress-induced decohesion of inclusion. However, excessive addition of Pr6O11 will reduce the number of inclusion nucleation and deteriorate the mechanical properties. The wire No.2 with 1% Pr6O11 had the good comprehensive mechanical properties, and the corresponding values were 835MPa of tensile strength and 72 J of impact toughness. These findings suggest that the control of Pr6O11 can be an effective way to improve the impact toughness of weld metal.
Geological Heritage of Syros Island, Cyclades Complex, Greece: A New Assessment and Geotourism Perspectives
Authors: Drinia Hara , Tsipra Theodora , Panagiaris George , Patsoules Marios , Papantoniou Christina , Magganas Andreas
Published: January 2021

Syros Island, Cyclades complex, central Aegean Sea, Greece, is a prime locality for the study of processes active in deep levels of orogens and is world famous for its exceptionally well preserved glaucophane schist-to eclogite-facies lithologies. Glaucophane schists and eclogites are witnesses of one of the fundamental tectonic processes operating on planet Earth. Results of geological research on Syros have contributed a lot to our present understanding of why and how these processes work that make oceans disappear, how mountain ranges can start to form, how magma chambers form to feed volcanoes, how subduction mechanisms can trigger earthquakes and lead to tsunamis, and a series of other spectacular or very impressive phenomena which have been observed and studied throughout the earth s window offered in that particular place of the world. The description, interpretation and evaluation of the important geological heritage of Syros, in combination with a preliminary SWOT analysis, showed the geotourism potential of the region. The results of this paper are intended to constitute a valuable tool for enhancing and raising awareness of the geological heritage of the island of Syros, with regard to the added value activities to be developed on a sustainable basis.
Chebyshev Type Inequalities for the Riemann-Liouville Variable-Order Fractional Integral Operator
Authors: Jenber Dagnachew , Haile Mollalign , Gizachew Adamu
Published: January 2021

This paper presents Chebyshev Type inequalities for the Riemann-Liouville variable-order fractional integral operator using two synchronous functions on the set of real numbers. It is the first result of its kind in the current literature using variable-order Riemann-Liouville fractional integral operator. Some special cases for the result obtained in the paper are discussed.
Human Symmetry Uncertainty Detected by a Self-Organizing Neural Network Map
Authors: Dresp-Langley Birgitta , Wandeto John M.
Published: January 2021

Symmetry in biological and physical systems is a product of self-organization driven by evolutionary processes, or mechanical systems under constraints. Symmetry-based feature extraction or representation by neural networks may unravel the most informative contents in large image databases. Despite significant achievements of artificial intelligence in recognition and classification of regular patterns, the problem of uncertainty remains a major challenge in ambiguous data. In this study, we present an artificial neural network that detects symmetry uncertainty states in human observers. To this end, we exploit a neural network metric in the output of a biologically inspired Self-Organizing Map, the Quantization Error (SOM-QE). Shape pairs with perfect geometric mirror symmetry but a non-homogenous appearance, caused by local variations in hue, saturation, or lightness within and/or across the shapes in a given pair produce, as shown here, longer choice RT for ‘yes’ responses relative to symmetry. These data are consistently mirrored by the variations in the SOM-QE from unsupervised neural network analysis of the same stimulus images. The neural network metric is thus capable of detecting and scaling human symmetry uncertainty in response to patterns. Such capacity is tightly linked to the metric’s proven selectivity to local contrast and color variations in large and highly complex image data.
Coding, Ranking and Optimum selection of Nanomaterials
Authors: Singh Tanvir
Published: January 2021

The paper presents attribute based characterization of nanomaterials method for computer storage and retrieval as knowledgebase. The knowledgebase permits indepth understanding and comparison between nanomaterials available with the scientists and product developers to satisfy their research and development (R & D) needs. Techniques for order preference by similarity to ideal solution (TOPSIS) is proposed to evaluate nanomaterials in the presence of multiple attributes. The method normalizes attributes to nullify the effect of different units and their values in the range of 0 to 1. The relative importance of different attributes for different applications is considered. The weight vector is derived using Eigen value formulation. The positive and negative benchmark solutions are derived. Euclidean distance of alternatives from these best and worst solution leads to the development of proximity /goodness/suitability index for ranking. Final decision is taken by decision makers by SWOT analysis and short and long term strategies of the organisation. The methodology is illustrated with the help of an example and step-by-step procedure. Results, discussion and conclusion highlights the importance and practical application.
Achieving Ultra-High Performance Concrete by Using Packaging Models in Combination with Nanoadditions
Authors: Díaz Jesús , Gálvez Jaime C. , Alberti Marcos G. , Enfedaque Alejandro
Published: January 2021

This paper describes the packaging models that are fundamental for the design of ultra-high-performance concrete (UHPC), and their evolution. They are divided into two large groups: continuous and discrete models. The latter are those that provide the best answer in obtaining an adequate simulation of the packing of the particles up to nanometric size. This includes the interaction among the particles by means of loosening and wall coefficients, allowing a simulation of the virtual and real compactness of such particles. In addition, a relationship between virtual and real compactness is obtained, through the compaction index, which may simulate the energy of compaction that the particles undergo in their placement in the mold. The use of last-generation additives allows such models to be implemented with water-cement (w/c) ratios close to 0.18. However, the premise of maximum packing as a basic pillar for the production of UHPC should not be the only one. The cement hydration process affected by nanoadditions and the ensuing effectiveness in the properties in both fresh and hardened state according to the respective percentages in the mixture should also be studied. An adequate ratio and proportion of these additions may lead to an obtaining of better results even with lower levels of compactness.
Advanced Pediatric Diffuse Pontine Glioma Animal Models Pave the Way Towards Precision Medicine
Authors: Chen Zirong , Peng Peng , Zhang Xiaolin , Mania-Farnell Barbara , Xi Guifa , Wan Feng
Published: January 2021

Diffuse intrinsic pontine gliomas (DIPGs) account for ~15% of pediatric brain tumors, which invariably present with poor survival regardless of treatment mode. Several seminal studies have revealed that 80% of DIPGs harbor H3K27M mutation coded by HIST1H3B, HIST1H3C and H3F3A genes. The H3K27M mutation has broad effects on gene expression and is considered a tumor driver. Determination of the effects of H3K27M on posttranslational histone modifications and gene regulations in DIPG is critical for identifying effective therapeutic targets. Advanced animal models play critical roles in translating these cutting-edge findings into clinical trial development. Here, we review current molecular research progress associated with DIPG. We also summarize DIPG animal models, highlighting novel genomic engineered mouse models (GEMMs) and innovative humanized DIPG mouse models. These models will pave the way towards personalized precision medicine for the treatment of DIPGs.
Algebraic Rules for the Percentage Composition of Oligomers in Genomes
Authors: Petoukhov Sergey
Published: January 2021

The article presents the author's results of studying hidden rules of structural organizations of long DNA sequences in eukaryotic and prokaryotic genomes. The results concern some rules of percentages (or probabilities) of n-plets in genomes. To reveal such rules, the author uses a tensor family of matrix representations of interrelated DNA-alphabets of 4 nucleotides, 16 doublets, 64 triplets, and 256 tetraplets. If percentages of each of these n-plets in tested genomic DNA-texts are disposed into appropriate cells of appropriate matrices, unexpected rules of invariance of total sums of their percentages in certain tetra-groupings of n-plets are revealed. The author connects the received results about these genomic percentages rules with a supposition of P. Jordan, who is one of the creators of quantum mechanics and quantum biology, that life's missing laws are the rules of chance and probability of the quantum world. Algebraic features of the genomic matrices of percentages of n-plets are analyzed and discussed. The received results can be used for further development of quantum biology.
EVALUASI KANTONG PARKIR DI KAWASAN UGM DAN DESAIN PERANCANGAN TRANSPORTASI KAMPUS YANG TERINTEGRASI
Authors: Kamal Muhammad Iqbal Habibi , Irawan Muhammad Zudhy , Isheka Raihan Pasha
Published: January 2021

The focus of this study is by the quality increase of UGM parking lots. Parking lots performance is evaluated at the beginning of this study and continued with the development planning as a parking lot that integrated with the campus transportation system. The aim of this study is to examine the UGM parking lots facilities caused by the phenomenon of an increase in the number of student vehicles that occur every year. The data collection process was done by field observation and interview using questioner. The data is processed by counting-analysis of parking characteristic and descriptive analysis related students' responses about the development of campus transportation system. After that, the Transit Oriented Development (TOD) principle area is planned to create conducive area in the transportation system. The result of statistical analysis showed there was no ideal condition in between both of parking lot samples, with parking index 135% for the Eastern Faculty of Philosophy parking lot and 103% for the PPB South parking lot. In addition, based on the TOD assessment metric according to ITDP (2014), UGM scored 74 out of 100. Therefore, alternative solution given by this study were architectural design as parking lots, pedestrian sidewalk, bicycle road, and bus-campus route. The effort created to bring UGM to be one of educopolis campus.