bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing Camp Provider Needs Related to the Mental, Emotional, and Social Health of Youth and Staff: Implications for Parent Communication, Human Resources, and Transition of Care
Authors: Garst Barry A. , Skrocki Alexandra , Gaslin Tracey , Schultz Beth E. , Hashikawa Andrew N. , Bunke Carissa , Gaberson Kathleen B. , DeHudy Ashley
Published: January 2024

Children, adolescents, and young adults are experiencing increases in mental, emotional, and social health (MESH) challenges including anxiety and depression. Out-of-school time (OST) program providers such as summer camps rely on effective communication with parents and other stakeholders to provide for these MESH needs, and the development of before and after program communication processes are viewed as a promising strategy for MESH response across youth program settings. In addition, OST program providers seek human and educational resources for meeting the MESH needs of program participants, and they also try to match available MESH resources to the work demands of their frontline staff who are tasked with responding to youth MESH needs when they arise. The importance of these topics is not reflected in available research informing recommended OST provider practices. Thus, this study examined program provider communications with parents about their youth’s MESH needs as well as program provider MESH resource utilization. Our three research questions were as follows: (1) What parent communication approaches do camp providers use to support youth MESH needs?; (2) What information is communicated to parents, teachers, or healthcare providers regarding youth MESH before and after camp?; and (3) What supports and resources do camp providers need to better manage MESH issues? Findings from this research highlight camp provider MESH-related parent communications and resource utilization. Notably, while respondents indicated requesting general MESH information on the health history form, further assessment and documentation of these identified MESH issues within- and across-camp seasons was lacking. Respondents also indicated camp nurses as the most prevalent human resource. Collectively, these results indicate that camp providers and out-of-camp stakeholders acknowledge the benefit of health history reporting and communication with regard to MESH challenges as well as providing MESH resources to meet employee job demands.
Zasnova sistema ocenjevanja in nagrajevanja zaposlenih
Authors: Bernik Mojca , Žnidaršič Jasmina
Published: January 2024

V globalnem tržnem okolju je ocenjevanje in nagrajevanje zaposlenih postalo eno izmed najpomembnejših managerskih orodij. V prispevku je podrobneje predstavljeno ocenjevanje učinkovitosti in uspešnosti zaposlenih, ki sodita v sklop sistema ocenjevanja zaposlenih. Nadgradnja tega je v nadaljevanju predstavljen sistem nagrajevanja zaposlenih, ki se navezuje na finančni vidik in je kot tak del strategije poslovanja organizacij. Ta spoznanja so v nadaljevanju prispevka podprta s primerom sistema ocenjevanja in nagrajevanja zaposlenih znotraj slovenskega podjetja. Prikazani so posamezni koraki izgradnje sistema ocenjevanja in nagrajevanja zaposlenih, vključno s končno obliko ocenjevalnega lista in njegovo izvedbo.
Pomen predporodnega izobraževanja za razvoj posameznika
Authors: Berčan Tina , Podbregar Iztok , Kovačević Nina
Published: January 2024

Poporodno obdobje in kakovost življenja po porodu sta pomembna dejavnika v življenju žensk. V trenutku rojstva postaneta mati in oče odgovorna za novega družinskega člana, ki ni sposoben skrbeti zase. Med nosečnostjo predstavljajo šole za starše poglavitni način izobraževanja ter priprave na sam porod in poporodno obdobje. Predporodno izobraževanje je organizirano, ne glede na njegov ključni pomen, kot prostovoljno in je prepuščeno bodočim staršem, s kakšno zavzetostjo se ga udeležijo. Glede na družbeni pomen družine v družbi in cilje družbe, da je kvalitetna raven življenja po porodu pomemben temelj za celoten nadaljnji razvoj otroka in družine, pa se postavlja vprašanje, do katere meje predporodno izobraževanja organizirati v obvezni obliki. Prispevek bo predstavil različne dejavnike, ki narekujejo višjo raven predporodnega izobraževanja in njegov vpliv na razvoj otroka po porodu.
Izzivi oskrbovalnih verig strateških materialov za proizvodnjo električnih vozil
Authors: Senegačnik Marjan , Mežnar Dušan
Published: January 2024

Pri organizacijskih spremembah je pred odločitvijo za izvedbo nujno oceniti pričakovano razmerje med stroški in učinki spremembe. Uveljavljena metodologija, po kateri bi lahko to preprosto izračunali, ne obstaja. Bi pa taka metodologija koristila vsakemu poslovnemu sistemu, ki se spreminjanja organizacije loti. Razvili smo metodo, tehnike in preprosto orodje predvidevanja učinkov organizacijskih sprememb, s katerim merimo trenutne vrednosti in jih primerjamo s pričakovanimi vrednosti operativnih kazalnikov po posameznih poslovnih procesih in po več organizacijskih dimenzijah. Na drugi strani lahko na podlagi predvidenih organizacijskih ukrepov, relativno natančno izračunamo stroške izvajanja vseh aktivnosti, ki so potrebne za uvajanje organizacijske spremembe in stroške managementa projekta. S temi podatki je mogoče izračunati, kdaj (v kateri časovni enoti) se vložena sredstva v organizacijsko spremembo povrnejo. Izračunamo lahko t.i. »prag rentabilnosti organizacijskih sprememb«.
Improving Student Learning Outcomes Through Problem-Based Learning Model Assisted with Picture Media
Authors: Fauziah Nahdiah Nur , Adi Depict Pristine
Published: January 2024

The purpose of this article is the researcher's goal is to understand the increase in learning studies from students in the PBL model assisted by class IV pictorial media at SDN Kawisrejo on various jobs with non-media and with media images. Because the researchers found several student barriers including: Efforts to increase the results of children's learning interest in the material of various Class IV Theme 4 jobs at SDN Kawisrejo, researchers have limitations so that problems do not spread too widely. Achievement of IPS knowledge competence focuses on: 1. Students do not actively participate in learning, 2. Students find it difficult to understand IPS material, 3. Students' thinking skills still need to be maximized 4. The reasons for the lack of learning media used by educators and the efforts that can be made and why do learning resources only come from an educator? The method used is the Classroom Action Research (CAR) method at SDN Kawisrejo. Where the increase in the results of social studies learning interest is still low and there needs to be variation from an educator to his students so that it is easy to understand and apply. Classroom action research is an activity carried out by the teacher in order to improve previous learning which is considered unsuccessful. Based on the existing data above, in the pre-stage there were 10 students who passed and 15 students who were still unsuccessful with a class average of 63.24. after the pre-stage there was a change in stage 1 where students who passed increased to 20 while students who were below average or not successful as many as 5 students had an average class value of 70.84. And in stage 2 which is the final stage which increases the results of social studies learning interest with all students completing the social studies subject matter so that learning objectives can be achieved and have maximum success.
Las aguas de la Orinoquía Colombiana y el cambio climático
Authors: Mariño Martínez Jorge Eliécer
Published: January 2024

La cuenca del río Orinoco u Orinoquía es una zona con abundante agua y sinónimo de riqueza, belleza y biodiversidad. Por la importancia de dicha cuenca, este libro se centra en determinar la relación entre, las aguas de superficie, las aguas subterráneas o del subsuelo y los cambios climáticos que el planeta está experimentando. Para esto se utilizaron diversos métodos y herramientas desde la medición de caudales de agua de los ríos, pozos, aljibes y aún de la precipitación; pasando por, pruebas de pozos, análisis de suelos, radiografía geofísica del subsuelo, y análisis químicos, con el fin de determinar la litología de las rocas que la contienen, la composición química e isotópica de sus aguas y así entender su calidad, orígenes y correlaciones. Aunque la Orinoquía se relaciona con abundante agua, en los últimos años se perciben desafíos que podrían poner en peligro dicha abundancia: la ampliación de la agro-industria, el aumento de la exploración de los hidrocarburos, el aumento de la población, y el cada vez más presente cambio climático que trae consigo un clima cada vez más impredecible, olas de calor más fuertes, sequías e inundaciones más severas. Finalmente, esta investigación hace una reflexión sobre cómo el aprovechamiento de los abundantes recursos de la cuenca está causando cambios significativos en el entorno que se constituyen en amenazas sobre los mismos recursos naturales, y que presentan nuevos desafíos ambientales sobre los frágiles ecosistemas, y sobre los servicios ambientales que podrían prestar; y como resultado, están impactando la calidad de vida de los habitantes de la Orinoquía.
Os dados pessoais inseridos no celular e a sua proteção constitucional: as lições trazidas pela Suprema Corte norte-americana
Authors: Smanio Gianpaolo Poggio , Kibrit Orly , Manhoso Eduardo
Published: January 2024

O presente artigo trata da possibilidade de acesso aos dados encontrados no cellular do cidadão após apreensão em busca pessoal. A pesquisa adotou o método hipotético-dedutivo, pretendendo testar as hipóteses apresentadas, utilizando-se das técnicas de pesquisa bibliográfica e jurisprudencial. Nesse passo, inicia-se com a análise acerca da cidadania e da proteção da intimidade da Era da Informação, seguindo-se com uma excplicação acerca da influência dessa proteção nas investigações penais na atualidade, como limite à atuação estatal, ainda que no combate ao crime. Isto posto, passa-se a uma análise do entendimento do Superior Tribunal de Justiça, do Supremo Tribunal Federal e da Suprema Corte dos Estados Unidos, a fim de se ponderar como a questão tem sido tratada por tais tribunais. Objetiva-se, com isso, verificar se há, ou não, necessidade, em respeito à privacidade do cidadão, de prévia autorização judicial para tal acesso. A conclusão é de que o acesso aos dados pessoais – tais como agenda, ligações telefônicas, fotos – somente é válida se há prévia autorização judicial, ante a garantia da privacidade.
The social welfare state
Authors: Assumpção Everson Alexandre de
Published: January 2024

This article sought to demonstrate in a systemic way the construction of the Social Welfare State, origin of the modern term of Social Security. For a good understanding of the problem on the subject, it was necessary to outline some initial considerations regarding the historical construction of Social Insurance and the birth of the Social State, guarantor and intervener of economic and social activities, as well as the productive process. As a conclusion of this study, it was found that the Welfare State had its origin from a historical construction that dates back to the birth of humanity and that finally originated the modern Social Security. The doctrine and the Law support and justify this work, which adopted the perspective of Human and Social Rights, while the scientific article is a bibliographical review that used the deductive method, qualitative and descriptive research. As a reference, we used the scientific literature and published materials that were relevant to the purposes proposed here.
A tutela coletiva dos direitos para tutela dos direitos coletivos: do privatismo à diretiva 2020/1828 da União Europeia
Authors: Martinazzo Waleska M. Piovan
Published: January 2024

O presente artigo tem como tema a tutela coletiva dos direitos. O objetivo é traçar um panorama sobre o instituto da tutela coletiva no Brasil e realizar interpretação sobre a Diretiva 2020/1828 da União Europeia, comparando o direito comunitário europeu e o direito brasileiro. O problema de pesquisa consiste em analisar como o direito brasileiro e o direito comunitátio europeu tratam atualmente as tutelas coletivas dos direitos? E a metodologia utilizada teve enfoque qualitativo. O procedimento foi bibliográfico-documental e a pesquisa, quanto aos seus objetivos, explicativa. Aplicaram-se métodos variados, como o descritivo, comparativo e hermenêutico. A hipótese de pesquisa é que a União Europeia encontra dificuldades na implementação dessas tutelas ante a diversidade legislativa dos Estados-membros, já o Brasil busca maior efetividade ao que já está normatizado. Como resultados, destacou-se que a tutela coletiva é necessária para a concretização de direitos e importante alternativa ao privatismo. O Brasil reestrutura seu processo coletivo, visando amoldar as suas leis esparsas ao Código de Processo Civil de 2015. Já a tutela coletiva dos direitos na União Europeia avança e não apenas desenvolve a cooperação entre seus Estados-membros, mas busca, com a primazia de suas normas, a adequada proteção dos direitos coletivos. Como considerações finais, percebe-se que o Brasil passa por reestruturação de seu processo coletivo, amoldando suas leis esparsas ao Código de Processo Civil de 2015. Já na União Europeia busca-se a cooperação entre seus Estados-membros e a primazia de suas normas, para a adequada proteção dos direitos coletivos. No Brasil une-se esse instituto com o princípio da duração razoável do processo. Na Europa, o foco é trazer uniformização para as diversas legislações dos países componentes da União.
"Ethos" and persuasion in "De Rusticis Brasiliae Rebus"
Authors: Silva Roberto Gonoring D'Assumpção , Leite Leni Ribeiro
Published: January 2024

In this paper, we propose a reconstruction of the poetical and technical conditions under which the De Rusticis Brasiliae Rebus, a didactic poem by the jesuit José Rodrigues de Melo, was composed. Taking into consideration its historical particularities, we propose to read the text as an artifact from a specific discursive universe in which it is rooted and with which it dialogues, based on the Rhetorical persuasive principles, and in conformation to a poetic genre, in this case, the didactic. We observe how reading it according to the rhetorical precepts that regulated what we now call literary production may shine a light upon the mechanisms through which the text positions itself in the genre of didactic poetry, and through which the author participates in the fierce quarrel between the newly-established national states and the international and universalizing Society of Jesus.
Economic Cycles and Employment Growth in the WAEMU Zone: An Analysis Using a Non-Linear ARDL Panel Model
Authors: Sangare Vassy Pierre , Djezou Wadjamsse Baudelaire , Ble Caroline
Published: January 2024

The West African Economic and Monetary Union (WAEMU) is facing frequent and diverse crises that are affecting economic stability and employment opportunities in the region. It is important to analyze the impact of economic cycles on employment, as the response of employment supply differs during economic growth and contraction. This article uses a lagged non-linear auto-regressive model (NARDL) on panel data from 1990 to 2022, along with various filters, to examine the relationship between employment and business cycles. The study found that there is an asymmetric relationship between economic growth and employment, with the impact of economic recessions being stronger on long-term employment than on short-term employment. The study suggests that countries have not fully utilized their economic potential to benefit employment. To achieve sustainable economic growth and reduce the proliferation of the informal sector, economies should focus their efforts on translating their potential into action.
Perioperative Management of Marfan Syndrome in Pregnancy and Congestive Heart Failure
Authors: Koeshardiandi Mirza , Mudianto Fajar Tri , Himawan Muhammad Wildan Afif , Abuajwa Ahmed Eliaan Shaker , Semedi Bambang Pujo
Published: January 2024

Introduction: A mutation in fibrillin-1 (FBN1) leads to the autosomal dominant condition known as Marfan Syndrome (MFS). The condition of pregnancy with MFS may increase morbidity and mortality during pregnancy and delivery. Due to a greater frequency of maternal problems and fetal involvement, pregnancy with Marfan syndrome (MFS) provides challenges to healthcare professionals and patients and requires special treatment. Objective: This study aimed to analyze the perioperative management of Marfan syndrome in pregnancy and congestive heart failure (CHF). Case report: A 27-year-old primigravida with 38-39 weeks gestation presented with a referral letter with a diagnosis of G1P0A0 with scoliosis and peripartum cardiomyopathy. The patient complained of shortness of breath accompanied by cold sweat since the second trimester of gestation. Physical examination revealed the presence of arachnodactyly and spine deformity. The patient underwent an emergency cesarean section with general anesthesia. Breathing problem appeared the next day after cesarean section, the patient was intubated in the ICU. Chest X-ray depicted bilateral pulmonary edema. A mechanical ventilator was set up and fluid restriction had been done. The patient was extubated after showing breathing improvement in the second week in the ICU. Discussion: The diagnosis of MFS in this patient was defined based on the revised Ghent Nosology. MFS with spine deformity causes breathing problems because of the altered geometry of the thoracic cavity. MFS in pregnancy may worsen the breathing problem due to autotransfusion that leads to pulmonary edema. A mechanical ventilator with a specific setting accompanied by fluid restriction is recommended to reduce the fluid overload in the lungs. Conclusion: Mechanical ventilators with specific settings and fluid restriction are effective perioperative management to reduce pulmonary edema on MFS in pregnancy and congestive heart failure.
Effect of Dietary Canarium indicum L. on the Growth, Health, and Resistance of Asian Seabass Challenged with Vibrio alginolyticus
Authors: Taufiq Abdullah  , Wahjuningrum Dinamella , Widanarni Widanarni
Published: January 2024

Abstract
Canarium indicum offers the potential of usage in aquaculture. This study aimed to evaluate the utilization of C. indicum on growth performance, health, and resistance of Asian seabass Lates calcalifer challenged with Vibrio alginolyticus. The study employed a completely randomized design with seven treatments, namely positive control (K+), negative control (K-), vitamin control (KVit), antibiotic control (KAnt), doses of 5 g kg-1 (D05), 10 g kg-1 (D10), and 20 g kg-1 C. indicum (D20). The test feed was prepared with a coating method and fed for 30 days. On the 31st day of rearing, a challenge test was conducted by injecting V. alginolyticus intramuscularly at 106 CFU mL-1. The results showed that C. indicum treatment for 30 days had a significantly different effect (P<0.05) on weight gain and average daily growth, while KVit and KAnt treatments were not different from the control. After the challenge test, all doses of C. indicum treatment, as well as KVit and KAnt treatments, showed survival significantly different (P<0.05) from that of the positive control, which ranged from 88.89% to 95.56% and was not significantly different (P>0.05) from the negative control. The survival rate condition is identical to the cumulative survival condition which shows the highest mortality found in the positive control. The administration of C. indicum at a dose of 5 g kg-1 to 20 g kg-1 improved the growth performance and prevented V. alginolyticus infection.
Highlight Research

C. indicum significantly increases the growth of Asian seabass.
C. indicum significantly enhances the immune response to V. alginolyticus infection in Asian seabass.
C. indicum can prevent V. alginolyticus infection as it resulted in a higher and cumulative survival than the positive control.
C. indicum can be developed as an immunostimulant for the prevention of vibriosis in Asian seabass at doses of 5 g kg-1 to 20 g kg-1.
Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb.) on the Immune Response and Gene Expression of Nile Tilapia (Oreochromis niloticus) Infected with Aeromonas hydrophila
Authors: Fauzi Arini Resti , Yuhana Munti , Widanarni Widanarni , Setiawati Mia , Afiff Usamah
Published: January 2024

Abstract
Dayak onion (Eleutherine bulbosa (Mill.) Urb.) has the potential to be an immunostimulant to benefit fish health. This study aimed to evaluate the effectiveness of dietary supplementation with the powder and crude ethanol extracts of Dayak onion on the hematology and immune response parameters of Nile tilapia challenged with Aeromonas hydrophila. The research used a completely randomized design with six treatments and three replications. Nile tilapias were fed with Dayak onion (w/v) consisting of powders of 5% (P5), 10% (P10), and 15% (P15), while crude extract was 0.5% (E05) and given during rearing for 30 days. Positive control (C+) and negative control (C-) were used without Dayak onion. Nile tilapia in treatment C+, P5, P10, and P15 were injected with A. hydrophila 10⁶ CFU mL⁻1, while that in treatment C- was injected with phosphate buffered saline (PBS) intramuscularly. The results showed that the dietary with 15% powder and 0.5% crude extract significantly improved the hematology and immune response parameters compared to the control after the challenge against A. hydrophila (P<0.05). Dayak onion supplementation effectively increased the health status based on hematology and immune response parameters of Nile tilapia against A. hydrophila infection.
Highlight Research

Dayak onion has significant potential to improve nonspecific immunity in fish.
Dayak onion improves hematology and immune response of Nile tilapia.
Dayak onion can significantly regulate the immune system against A. hydrophila infection.
Dayak onion significantly increases the production of the gene expression of IL-1β and TNF-α.
Isolation, Identification, and Pathogenicity of Potential Probiotics Isolated from Intestinal Coconut Crab (Birgus latro Linnaeus, 1767)
Authors: Aris Muhammad , Tamrin Tamrin , Munaeni Waode , Malan Sudirto , Juharni Juharni , Labenua Rusmawati
Published: January 2024

Abstract
The supply of coconut crabs (Birgus latro Linnaeus, 1767) has been sourced from capture in the wild. Development efforts in aquaculture have succeeded in producing eggs. However, further development with larval maintenance failed because it was constrained by a low survival rate. This study aimed to identify the potential probiotic bacteria in coconut crabs. Coconut crab samples were collected from Moor Island, South Patani District, Central Halmahera Regency, North Maluku Province, Indonesia. The intestines of coconut crabs were taken as much as 1 g, then ground on a porcelain dish and added to Tri-Salt. The scouring liquid was taken in 0.1 ml and spread on a petri dish containing Nutrient Agar. The isolated used were marked with BL1, BL2, BL3, BL4, and BL5. Molecular identification was performed with sequencing and then analyzed using the Basic Local Alignment Search Tool (BLAST). The selection of isolates from the gastrointestinal tract of coconut crabs showed that the bacteria obtained were Enterobacter tabaci (BL1), Enterobacter hormaechei (BL2), Bacillus horneckiae (BL3), Pseudomonas stutzeri (BL4), and Acinetobacter variabilis (BL5). Further testing revealed that the bacteria A. variabilis (BL5) is a probiotic isolate in coconut crabs.
Highlight Research

The intestinal bacteria from coconut crabs identified were E. tabaci, E. hormaechei, B. horneckiae, P. stutzeri, and A. variabilis.
The E. tabaci strain BL1, E. hormaechei strain BL2, B. Horneckiae strain BL3, and P. stutzeri strain BL4 are pathogenic bacteria.
The A. variabilis strain BL5 is potential probiotics bacteria.
The A. variabilis strain BL5 showed a better survival rate than other isolates.
A TPRF-based pseudo-random number generator
Authors: Andreeva Elena , Weninger Andreas
Published: January 2024

Most cryptographic applications use randomness that is generated by pseudo-random number generators (PRNGs). A popular PRNG practical choice is the NIST standardized $$ \rm{CTR\_DRBG}$$ . In their recent ACNS 2023 publication, Andreeva and Weninger proposed a new and more efficient and secure PRNG called $$ \mathtt{FCRNG}$$ . $$ \mathtt{FCRNG}$$ is based on $$ \rm{CTR\_DRBG}$$ and uses the $$ n $$ -to-$$ 2n $$ forkcipher expanding primitive ForkSkinny as a building block. In this work, we create a new BKRNG PRNG, which is based on $$ \mathtt{FCRNG}$$ and employs the novel $$ n $$ -to-$$ 8n $$ expanding primitive Butterknife. Butterknife is based on the Deoxys tweakable blockcipher (and thus AES) and realizes a tweakable expanding pseudo-random function. While both blockciphers and forkciphers are invertible primitives, tweakable expanding pseudo-random functions are not. This functional simplification enables security benefits for BKRNG in the robustness security game - the standard security goal for a PRNG. Contrary to the security bound of $$ \rm{CTR\_DRBG}$$ , we show that the security of our BKRNG construction does not degrade with the length of the random inputs, nor the number of requested output pseudo-random bits. We also empirically verify the BKRNG security with the NIST PRNG test suite and the TestU01 suite.

Furthermore, we show the $$ n $$ -to-$$ 8n $$ multi-branch expanding nature of Butterknife contributes to a significant speed-up in the efficiency of BKRNG compared to $$ \mathtt{FCRNG}$$ . More concretely, producing random bits with BKRNG is 30.0% faster than $$ \mathtt{FCRNG}$$ and 49.2% faster than $$ \rm{CTR\_DRBG}$$ .
Proinflammatory biomarkers and platelet aggregation activity in patients with coronary artery disease
Authors: Trubacheva O. A. , Kologrivova I. V. , Schnaider O. L. , Petrova I. V. , Vasiliev V. N. , Kovalev I. V. , Yakimovich I. Yu.
Published: January 2024

Aim. To determine concentrations and identify the relationship of biomarkers (endocan / cell-specific molecule-1, fatty acid binding protein 4 (FABP 4), placental growth factor (PlGF), oncostatin M), with parameters of collageninduced platelet aggregation in patients with coronary artery disease (CAD).

Materials and methods. In patients with CAD (n = 51), serum levels of endocan, FABP 4, PlGF, oncostatin M, and platelet aggregation indices (collagen at concentrations of 2 and 10 mmol / l) were determined. Patients were divided into groups with and without high residual platelet reactivity (HRPR). Correlation coefficients between concentrations of proinflammatory biomarkers and platelet aggregation indices were determined in patients of both groups.

Results. In patients with HRPR, the concentrations of endocan and PlGF were significantly higher, and the concentrations of FABP4 and oncostatin M were lower than in the first group. In patients with HRPR, a correlation was found between the concentration of endocan and the degree of platelet aggregation in the presence of 2 mmol

/ l of collagen (ρ = 0.48; p = 0.01), between the concentration of PlGF and the degree of platelet aggregation in the presence of 10 mmol / l of collagen (ρ = 0.58; p = 0.01), as well as between the concentration of FABP 4 and the size of aggregates at both collagen concentrations (ρ = 0.42; p = 0.03) and (ρ = 0.70; p = 0.01) and the degree of platelet aggregation in the presence of 10 mmol / l of collagen (ρ = 0.43; p = 0.01).

Conclusion. In all examined CAD patients, regardless of the residual platelet reactivity, the levels of endocan and FABP 4 increased compared to the reference values. In patients with HRPR, the content of parameters (endocan, PlGF) contributing to plaque growth was elevated, and in patients without HRPR, the levels of platelet-activating factors (FABР 4, oncostatin M) were increased, which determines a personalized approach to prescribing therapy for these groups of patients. In patients with CAD, platelet aggregation indices were associated with concentrations of proinflammatory biomarkers (endocan, PlGF, and FABP 4), which contribute to the development of endothelial dysfunction.
Phenotypes of coronary microvascular obstruction phenomenon (no-reflow) during percutaneous coronary interventions in myocardial infarction
Authors: Frolov A. A. , Frolov I. A. , Ulanova N. D. , Pochinka I. G. , Kuzmichev K. V. , Mukhin A. S. , Sharabrin E. G.
Published: January 2024

Objective: using the clustering method, to determine and describe the clinical and pathogenetic phenotypes of the coronary microvascular obstruction phenomenon (CMVO) that occurs during percutaneous coronary interventions (PCI) in patients with myocardial infarction (MI).

Materials and methods: the study group included 190 patients with CMVO that occurred during PCI for type 1 MI. Participants admitted in 2013-2020. CMVO criteria: blood flow < 3 points in the infarct-related artery (IRA) according to TIMI flow grade (TFG); perfusion < 2 points for Myocardial blush grade; ST segment resolution < 70%. Median age – 64 [56; 70] years, 137 (72%) men, 53 (28%) women. MI with ST elevation (STEMI) in 170 patients (89%). Primary PCI in 127 (67%) cases. Nine patients (4.7%) have died. Phenotyping was performed using the EM (expectation-maximization) clustering algorithm.

Results: three phenotypes have been identified in a ratio of 56% (n = 106) / 27% (n = 52) / 17% (n = 32). The values of the parameters are respectively: age 62 [54; 67] / 73 [67; 79] / 59 [50; 65] years; women 8 (8%) / 39 (77%) / 6 (19%); STEMI 102 (96%) / 43 (83%) / 25 (78%); thrombolysis 46 (43%) / 6 (12%) / 11 (34%); acute heart failure 1 [1; 2] / 2 [1; 4] / 2 [2; 2] class; platelet to lymphocyte ratio 110 [78; 153] / 106 [85; 132] / 132 [100; 182]; glucose at admission 8,0 [6,9; 9,6] / 11,1 [8,8; 15,2] / 7,5 [6,1; 8,1] mmol/l; total cholesterol 4,7 [4,2; 5,4] / 5,3 [3,7; 6,2] / 5,1 [4,5; 6,2] mmol/l; glomerular filtration rate according to CKD-EPI 77 [64; 88] / 58 [46; 74] / 81 [64; 88] ml/min/1.73m2; Syntax Score 15 [10; 21] / 20 [14; 26] / 8 [5; 10] points; Syntax Score in IRA 9 [8; 15] / 12 [7; 16] / 6 [3; 7] points; collaterals according to Rentrop 0 [0; 1] / 0 [0; 1] / 0 [0; 0] degree; TIMI thrombus grade 5 [5; 5]/ 5 [3; 5] / 1 [0; 2] degree; TFG 0 [0; 0] / 0 [0; 1] / 2 [2; 3] degree; aspiration thrombectomy 30 (28%) / 7 (13%) /4 (13%); IRA diameter 3,5 [3,0; 3,5] / 3,0 [2,8; 3,5] / 3,5 [3,0; 3,5] mm; balloon angioplasty 99 (93%) / 45 (87%) /16 (50%); PCI of 2 or more arteries 0 (0%) / 4 (8%) / 3 (9). Deaths – 2 (1.9%), 7 (13.5%) and 0 (0%) patients, respectively (p = 0.002, χ2-Pearson).

Conclusion. Тhree phenotypes have been identified. First phenotype: severe IRA thrombosis, mostly men, moderate atherosclerotic lesions. Second phenotype: mostly elderly women, high hyperglycemia, severe atherosclerotic lesions, severe AHF, impaired renal function, IRA thrombosis. Third phenotype: mostly men, minor changes in the coronary arteries, absence of significant thrombosis and preserved blood flow in the IRA before PCI, elevated levels of inflammatory markers and total cholesterol.
Lipidomic markers of obesity and their dynamics after bariatric surgery
Authors: Saprina T. V. , Bashirova A. S. , Ivanov V. V. , Pekov S. I. , Popov I. A. , Bashirov S. R. , Vasilyeva E. A. , Pavlenko O. A. , Krinitskii D. V. , Chen M.
Published: January 2024

Obesity is considered as a chronic progressive disease, heterogeneous in its etiology and clinical manifestations, and characterized by excess in body fat mass and its deposition in the body. The term “morbid obesity” refers to excessive deposition of adipose tissue with a body mass index (BMI) ≥40 kg / m2 or with a BMI ≥ 35 kg / m2 in the presence of serious complications associated with obesity. Along with obesity, the frequency of type 2 diabetes mellitus and cardiovascular diseases closely associated with it has increased. It results from the progression of metabolic disorders, including insulin resistance, which is inextricably linked with the accumulation of visceral fat and plays a key role in the pathogenesis of obesity-related diseases.

The study of lipidomic signatures in obesity and associated conditions is a promising branch of fundamental medicine, which makes it possible to significantly and at a new conceptual level stratify a cohort of obese patients into various phenotypes, including a metabolically healthy and metabolically unhealthy obesity phenotypes. Dynamic changes in the lipidome both in the context of diet, drug treatment, and after various bariatric surgeries are of great interest for developing personalized strategies for the treatment of this disease. Currently available studies and their results suggest that we are only at the very start of studying this promising biomedical field.
Challenges in the diagmosis of cervical pathologies
Authors: Chernov D. Y. , Tikhonovskaya O. A. , Logvinov S. V. , Petrov I. A. , Yuriev Y. S. , Zhdankina A. A. , Gerasimov A. V. , Zingalyuk I. V. , Mikheenko G. A.
Published: January 2024

This review deals with the current state of affairs in the diagnosis of cervical squamous intraepithelial lesions. Transformation of classifications of cervical pathologies is considered. The role of cytological (liquid-based and conventional cytology), molecular biological (Digene Hybrid Capture test), immunohistochemical (p16INK4α, Ki-67), and histologic methods in the diagnosis of cervical lesions is discussed. Particular attention is paid to the diagnosis of human papillomavirus infection. Performance indicators of screening programs based on primary determination of human papillomavirus (HPV) DNA in comparison with common cytological methods are presented. Tropism of HPV to various parts of the cervix, which predisposes to the formation of deep multifocal lesions, as well as the influence of the physical status of HPV on the treatment strategy and risks of relapse are considered.
Studying the role of GCLC gene polymorphisms in predicting the clinical course of acute alcoholic pancreatitis
Authors: Samgina T. A.
Published: January 2024

The aim of the study was to evaluate the role of polymorphic loci rs12524494, rs17883901, rs606548, rs636933, rs648595, and rs761142 in the GCLC gene in predicting the clinical course of acute alcoholic pancreatitis (AAP).

Materials and methods. The material of the study was blood DNA samples obtained from 547 patients with AAP and 573 healthy individuals. The average age of patients was 48.9 ± 13.1 years, the average age of healthy individuals was 47.8 ± 12.1 years. Genotyping was performed using the MassARRAY 4 Analyzer. Plasma levels of total glutathione were determined using the OxiSelect™ Total Glutathione (GSSG/GSH) Assay Kit STA-312. The level of reactive oxygen species (ROS) was determined using the OxiSelect™ In Vitro ROS/RNS Assay Kit (Green Fluorescence) STA-347 (Cell Biolabs Inc., USA). The kinetic colorimetric assay was used to determine the level of amylase in the blood serum. Statistical data processing was performed using the Statistica 10.0 and SNPStats software.

Results. It was found that the polymorphic loci rs606548 (genotype C/C, odds ratio (OR) = 3.34, 95% confidence interval (CI) 1.29–8.66, р = 0.007), rs648595 (genotype G/T, OR = 1.56, 95% CI 1.04–2.36, р = 0.029), and

rs12524494 (genotype A/G, р = 0.021) in the GCLC gene were predictors of an increased risk of necrotizing pancreatitis. For the genotype T/T of rs648595 (recessive model) in the GCLC gene, the lowest values of oxidized glutathione were found, whereas rs17883901 – G/A in the GCLC gene was associated with the highest ROS values in the blood. The rs761142 A/A genotype in the GCLC gene (OR = 1.70, 95% CI 1.12–2.59; р = 0.010) showed predisposition to acute peripancreatic fluid сollection, and the rs648595 G allele (OR = 1.47, 95% CI 1.01–2.13; р = 0.042) in the GCLC gene exhibited predisposition to the formation of acute pancreatic pseudocysts. Predisposition to massive bleeding was associated with rs17883901 (G/A genotype, OR = 6.20, 95%CI 1.3–28.81; р = 0.031) in the GCLC gene.

Conclusion. The established genotype – phenotype associations will make it possible to predict the clinical course of AAP in a particular patient, taking into account their genetic makeup, as well as to determine the treatment strategy in a timely manner.
Non-local EPR Correlations Using Quaternion Spin
Authors: Sanctuary Bryan
Published: January 2024

A statistical simulation is presented which reproduces the correlation obtained from EPR coincidence experiments without non-local connectivity. In addition to the spin polarization, we identify spin coherence as an attribute, and complementary to polarization, which is anti-symmetric and generates the helicity. This changes the point particle spin to a structured one with two orthogonal magnetic moments of spin $\frac{1}{2}$ each. They couple in free flight to form a spin 1, a boson. Upon encountering a filter, the boson decouples into its two independent spins axes of $\frac{1}{2}$, with one aligning with the filter and the other randomizing. The process of decoupling from a free-flight boson to a measured fermion is responsible for the quantum correlation which results in the observed violation of Bell's Inequalities. The only variable in this work is the angle that orients a spin on the Bloch sphere, first identified in the 1920's. The new features introduced here result from changing the spin symmetry from SU(2) to the quaternion group, $Q_8$.
Factors for Occupational Exposure to Ultrafine Particles in Different Sectors of Activity
Authors: Moreira Fernando , Ferreira Ana , Barros Nelson
Published: January 2024

The primary sources of particulate matter are linked to human activity. Certain particulate emissions, particularly those of a finer nature, can significantly impact human health, making them one of the most concerning pollutants. Ultrafine particles (UFP), which have a diameter of less than 100 nm, are of particular concern due to their impact on human health and the difficulty in controlling them. The concentration of ultrafine particles (UFP) in the workplace is a growing concern and is classified as an emerging risk. Workers may be exposed to UFP through inhalation, skin absorption, ingestion, or a combination of these routes. This study aims to determine the levels of UFP exposure among workers in environments with varying direct particle emission patterns. Measurements were conducted to compare the results with the levels recommended by the WHO. The study monitored industrial workplaces with direct particulate matter emissions, such as a carpentry and a bakery, as well as social sector sites without or almost without direct particle emissions, such as a school and a health clinic. One conclusion drawn from this study is that all tasks and occupations are susceptible to high levels of UFP, exceeding WHO recommended values in virtually all monitored environments. Therefore, monitoring and controlling UFP is crucial. Further in-depth studies on this subject are also necessary..
Harnessing Phonon Wave Resonance in Carbyne-Enriched Nano-Interfaces to Enhance Energy Release in Nanoenergetic Materials
Authors: Lukin Alexander , Gülseren Oğuz
Published: January 2024

This paper introduces an innovative nanotechnology-based approach that provides a pathway to enhance the energy release efficiency of nanoenergetic materials (nEMs) by harnessing self-synchronized collective atomic vibrations and phonon wave resonance within the transition domains between nanocomponents, without altering the material composition. The key innovation involves incorporating finely-tuned 2D-ordered linear-chain carbon-based multilayer nano-enhanced interfaces as programmable nanodevices into the transition domains using advanced multistage processing and assembly techniques. These programmable nanodevices enable precise control over self-synchronized collective atomic vibrations and phonon wave propagation, leading to synergistic effects. To activate and optimize these effects, a combination of various methods is employed, including energy-driven initiation of allotropic phase transformations, surface acoustic wave-assisted micro/nano-manipulation, heteroatom doping, directed self-assembly using high-frequency electromagnetic fields, and data-driven inverse design approaches. By leveraging a data-driven inverse design strategy and uncovering hidden structure-property relationships, we maximize energy release efficiency using the carbon nano-materials genome approach derived from multifactorial neural network-based predictive models. This approach not only unlocks new functionalities in nEMs but also improves environmental performance and safety levels. By pioneering transformative pathways for nEMs through harnessing phonon wave resonance in low-dimensional nanocarbon transition interfaces, this research brings significant advancements in the field.
The Past, Present and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis
Authors: Ibáñez-Escribano Alexandra , Nogal-Ruiz Juan José
Published: January 2024

More than one million curable sexually transmitted infections occur every day. Trichomonas vaginalis is one of the main responsible for these epidemiological data, however, the diagnosis of this protozoan is still mainly based on microscopic and culture identification. The commerciali-zation of immunological tests and the development of molecular techniques have improved the sensitivity of classical methods. Nevertheless, the fact that trichomoniasis is a neglected parasitic infection, hinders the development of novel techniques and their implementation in routine di-agnosis. This review article shows the different methods developed to identify T. vaginalis in population and the difficulties to diagnose male and asymptomatic patients. The importance of including this parasite in routine gynecological screening, especially in pregnant women, and the importance of considering T. vaginalis as an indicator of high-risk sexual behavior is also discussed.
Neuromuscular Electrical Stimulation Does Not Influence Spinal Excitability in Multiple Sclerosis Patients
Authors: Scalia Martina , Borzuola Riccardo , Parrella Martina , Borriello Giovanna , Sica Francesco , Monteleone Fabrizia , Maida Elisabetta , Macaluso Andrea
Published: January 2024

Background: Neuromuscular electrical stimulation (NMES) has beneficial effects on physical functions in Multiple Sclerosis (MS) patients. However, the neurophysiological mechanisms underlying these functional improvements are still unclear. This study aims at comparing acute responses in spinal excitability, as measured by soleus Hoffmann reflex (H-reflex), between MS patients and healthy individuals, following three experimental conditions involving the ankle planta flexor muscles: 1) passive NMES (pNMES); 2) NMES superimposed to isometric voluntary contraction (NMES+); and 3) isometric voluntary contraction (ISO). Methods: 20 MS patients (MSp) and 20 healthy individuals as control group (CG) took part in a single experimental session. During each condition, participants performed 15 repetitions of 6 seconds at 20% of maximal voluntary isometric contraction, with 6 seconds of recovery between repetitions. Before and after each condition, H-reflex amplitudes were recorded. Results: In MSp, H-reflex amplitude did not change following any experimental condition (ISO: p = 0.506; pNMES: p = 0.068; NMES+: p = 0.126). In CG, H-reflex amplitude significantly increased following NMES+ (p = 0.01), decreased after pNMES (p = 0.000) and was unaltered following ISO (p = 0.829). Conclusion: the different H-reflex responses between MS and CG might reflect a reduced ability of MS patients in modulating spinal excitability.
Energy-Efficient TRIZ-Inspired Paradigm to Automate Consumer Electronic Devices
Authors: Razaque Abdul , Yoo Joon , Bektemyssova Gulnara , Ali Mohsin , Ryskhan Satybaldiyeva , Alotaibi Aziz , Hwang Jaeryong , Alshammari Majid
Published: January 2024

The ubiquitous problem of electrical energy waste is driven by human error, in which people regularly forget to turn off appliances when they leave a room, resulting in excessive consumption. The paper presents an energy-efficient TRIZ-inspired (EETRIZ) paradigm to automate consumer electronic devices in order to address this problem. Employing motion detection at entry and exit points, the system discerns room occupancy, effectively managing electrical appliances like lamps, fans, and air conditioners. The integration of theory of inventive problem solving (TRIZ) principles guides the ideation and design of an efficient switching mechanism. The system demonstrates that it is flexible by controlling multiple electronic consumer devices simultaneously. This paradigm can be used in a variety of environments, such as homes, offices, schools, and universities, and its goal is to reduce excessive energy use that results from human negligence. With an emphasis on economic viability and environmental impact, the proposed EETRIZ paradigm not only offers enhanced energy efficiency but also lays the groundwork for long-term sustainability practices, aligning with global efforts towards greener and smarter energy management. The proposed EETRIZ is implemented on C platform with support of MPLAB, Nuvoton 8051 Serie MCU Programming, GMPLibrary (GMP-5.1.1) and, Miracl Library. The proposed EETRIZ outperforms current state-of-the-art methods in terms of energy efficiency, cost-effectiveness, precision, and user-friendliness, according to hardware testing.
Multiparametric Apparatus for Real-Time Observations of Volcanic Aerosol Optical and Microphysical Properties at Etna (Italy): Calibration Procedures and Measurement Tests
Authors: Manzo Matteo , Aiesi Gianpiero , Boselli Antonella , Consoli Salvatore , Damiano Riccardo , Di Donfrancesco Guido , Saraceno Benedetto , Scollo Simona
Published: January 2024

An innovative mobile Lidar device, developed to monitor volcanic plumes during explosive eruptions at Mt. Etna (Italy) and analyze the optical properties of volcanic particles was upgraded in October 2023 with the aim to improve volcanic plume retrievals. The new configuration of the lidar allows to obtain new data of both the optical and the microphysical properties of the atmospheric aerosol. In fact, after its upgrade, the lidar has the possibility to measure 3β, 2α and 2δ in a configuration defined as “state of the art lidar” where properties such as the particle size distribution and refractive index can be derived. During the lidar implementation we were able to to test the system performance through specific calibration measurements. In this work, the first measurement results are shown and compared with results obtained by other instruments aimed at proving the ability of the upgraded system to more precisely characterize the aerosol optical and microphysical properties.