bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance of needs analysis in ESP classroom
Authors:   Senior Teacher, Uzbek State World Languages University, Uzbekistan, Mamaraimovna Khazratova Zukhra
Published: February 2025

The significance of needs assessment in ESP is examined in this paper. Since this is the initial stage of education, it is crucial to use the right techniques and resources to assess students’ requirements. The analysis’s findings will help teachers develop lesson plans and learning objectives that are suited to their students’ requirements, desires, and weaknesses. Needs analysis should therefore be given greater space because the rest will always be highly challenged if we do not employ the first principle to develop and produce exceptional materials. All new teachers should begin their year by using needs analysis on a small scale before determining what is best for both themselves and their students.
THE DEVELOPMENT OF READING COMPETENCE IN ENGLISH AS A FOREIGN LANGUAGE CLASSES IN SECONDARY EDUCATION
Authors: CONTRERAS BARRIGA Dr. JUAN PABLO , REAL AUDEVES Dr. JOSÉ RODOLFO
Published: February 2025

The investigation addresses the problems faced by the figure of the English teacher in basic education within his teaching and the efforts he makes regarding the development of the reading competence in his students. Likewise, the main contributions and exertions in terms of analysis for the curriculum by the SEP in Mexico are highlighted. Currently, understanding a text in English for students at the secondary education level represents a permanent challenge due to the current condition that exists regarding the English language as a global language. The problems of reading competence and its development demonstrate the need for attention and proposals for solutions to the challenges which represents achieving the development of reading competence in English for the secondary level. This research hopes to provide background and conditional expectations in the matter of achieving the reading competence, with the purpose that others researchers, foreign language teachers and interested in the topic may reach for more and better results in its practice.
Acceso a Financiamiento y Desarrollo Empresarial para Emprendedores Sociales en Ecuador
Authors: Murillo Leon Vicente Gregorio , Loor Saldarriaga Angel Oswaldo , Michelle Aymme Gordon Vergara , Noroña Moreno Francisco Xavier , Rivera Peñafiel Marcela Jacqueline
Published: February 2025

El presente artículo se centra en el acceso a financiamiento y el desarrollo empresarial para emprendedores sociales en Ecuador. Buscando entender las barreras que enfrentan estos emprendedores para obtener los recursos financieros necesarios para sus proyectos estaban destinados a resolver problemas sociales y ambientales. El objetivo del estudio es analizar cómo la disponibilidad de financiamiento afecta el crecimiento y la sostenibilidad de las empresas sociales en el país. Además, se explorará el papel de los sectores público y privado en la creación de un entorno propicio para el emprendimiento social y se propondrán estrategias y políticas públicas que puedan mejorar el acceso al capital y apoyar el desarrollo de estos proyectos. Identificar brechas en los canales de financiamiento y analizar las posibles soluciones, la investigación busca contribuir al fortalecimiento del sector de emprendimiento social, promoviendo un entorno más inclusivo y sostenible que permita a estos emprendedores escalar sus iniciativas y maximizar su impacto social en el país.
Asociación entre la presencia de infección del sitio quirúrgico y el tipo de material empleado (de un solo uso vs reesterilizado) en pacientes postoperados de colecistectomía laparoscópica.
Authors: Cortés Daumec Airam Paola , González Trejo Zayra Idalia , Gallardo Vera José Francisco
Published: February 2025

Objetivo: Identificar la frecuencia de infección del sitio quirúrgico y su asociación con el tipo de material empleado (un solo uso vs reesterilizado) en pacientes postoperados de colecistectomía laparoscópica. Material y métodos: El diseño del estudio fue cuantitativo, observacional, prospectivo y descriptivo. Se llevó a cabo en el período de junio- agosto del 2024, en el área de quirófano del CEMENAV (Centro Médico Naval), recolectando los datos en los pacientes que se sometieron a cirugías de colecistectomía laparoscópica con el uso de material de un solo uso vs material reesterilizado. Resultados: Se incluyeron 33 casos de colecistectomía laparoscópica. No se reportaron infecciones del sitio quirúrgico (ISQ), aunque el 39.4% de los pacientes presentó signos de infección. El análisis entre el uso de material de un solo uso y material reesterilizado mostró que el 31.6% de los pacientes con material de un solo uso presentó signos de infección, mientras que el 50% en el grupo con material reesterilizado también mostró signos, sin diferencias estadísticamente significativas (p > 0.05). Se observó una relación estadísticamente significativa (p = 0.000) entre el tipo de cirugía y el tipo de material utilizado: el material de un solo uso fue más frecuente en cirugías programadas (88.2%), mientras que el material reesterilizado se empleó más en cirugías de urgencia (75%).
Medición de parámetros característicos de un láser continúo CW
Authors: Martínez Irivas Beatriz Adriana , García Ramírez Emma Vianey , Carranza Zuñiga Doralycia , Zúniga Méndez Athziri , Ochoa Valiente Raúl
Published: February 2025

Actualmente, el láser (pulsado o continuo) es usado en diferentes investigaciones desde la explicación en ciencia básica hasta su uso en ciencia de frontera en nuevas tecnologías. Por esta razón se requiere caracterizarlos para conocer sus parámetros y sus especificaciones aplicando diferentes técnicas de caracterización del haz láser. En este trabajo se presentan resultados experimentales de parámetros característicos, de un haz Gaussiano de un haz láser continuo de iones de Argón de longitud de onda 514 nm, tales como: ancho del haz W(z), cintura del haz W0 y la distancia de Rayleigh z0, estos valores se obtienen mediante el montaje de la técnica de la navaja. Los resultados obtenidos se pueden utilizar para implementar la técnica de Z-scan y determinar parámetros no lineales de medios no lineales.
Impacto de la Pandemia del COVID-19 en la Economía Ecuatoriana
Authors: Merchán Montaleza Patricia Estefanía , Vargas Moreno Mercedes Elizabeth , Noroña Moreno Francisco Xavier , Merino Garnica Alex Estuardo , Rosero Yugsi Mauricio Fabian
Published: February 2025

El impacto de la pandemia del COVID-19 ha golpeado con fuerza a la economía ecuatoriana, azotando en particular a ciertos sectores clave y empujando a muchos hogares a la pobreza. Este artículo analiza los datos económicos previos y posteriores a la crisis, como el PIB, el desempleo y la inflación, para cuantificar con precisión su impacto. Asimismo, indaga en las experiencias de pequeños negocios, emprendedores, funcionarios públicos y privados a través de entrevistas semiestructuradas cualitativas, con el fin de comprender cabalmente cómo les afectó la emergencia sanitaria y las dificultades que debieron enfrentar. Del mismo modo, examina las medidas adoptadas por el gobierno para contrarrestar los estragos económicos, evaluando su eficacia a la hora de amortiguar el golpe y sentar las bases para la recuperación. Además, este trabajo provee una visión exhaustiva acerca de los devastadores efectos de la pandemia en la economía local y las lecciones que dejó esta dura prueba.
Alimentos que se consumen cuando se sufre ansiedad en persona de 13 a 15 años de edad, en la escuela Adolfo López Mateos del 3c del turno matutino en la ciudad de Chetumal Quintana Roo
Authors: Barrios Rivera Karen Esmeralda
Published: February 2025

La ansiedad tiene un impacto significativo en la calidad de vida de los adolescentes, afectando su funcionamiento académico, social y emocional, por otro lado, la alimentación es un factor importante en la gestión de la ansiedad, y conocer los alimentos que se consumen puede ayudar a mejorar la calidad de vida. En este artículo se investigó cómo la ansiedad influye en la alimentación de los adolescentes. Cuando experimentan ansiedad a menudo, recurren a la comida como una forma de autocompasión, esto puede llevar a un consumo excesivo de alimentos poco saludables, generando un efecto negativo en la salud física y mental, de tal manera, que esto al largo plazo conlleva a que sufran alguna enfermedad crónica degenerativa como sobrepeso u obesidad. De acuerdo a la investigación realizada, es mixto, es decir, cuantitativo y cualitativo, porque se utilizó como metodología una encuesta, la cual fue aplicada a 34 jóvenes y se crearon un total de 15 preguntas. A través de esta investigación se demostró qué alimentos suelen consumirse durante episodios de ansiedad de tal manera, que se puedan diseñar intervenciones educativas para promover hábitos alimenticios más saludables y estrategias preventivas para los jóvenes.
Reformas Laborales y su Influencia en el Mercado de Trabajo
Authors: Guanotasig Palate Cinthya Michelle , Merino Garnica Alex Estuardo , Guevara Herrera Carlos Roberto , Guevara Herrera Oscar Fernando , Bonifaz Aldaz Lorena Paola
Published: February 2025

Este artículo explora las reformas laborales para los empleados del Ecuador, enfocadas en lograr un puesto de trabajo en las empresas, beneficiando a miles de jóvenes que buscan por primera vez un empleo con las prácticas realizadas en la empresa. Se analiza como los puestos de trabajo están abordando con las reformas laborales mediante un análisis donde se menciona también el debilitamiento que se obtuvo de las relaciones colectivas del trabajo. El estudio se centra en el mercado laboral de trabajo, educación, y capacitación necesaria, buscando responder preguntas específicas y ofrecer soluciones concretas. Las pasantías y el trabajo juvenil, seguro desempleo, licencia sin remuneración para el cuidado de hijos y reducción de la jornada laboral son objetivos fundamentales. A través del análisis, se pretende afirmar cuáles serían las formas en las que un empleador se pueda sumar a una empresa para que pueda adquirir mayor conocimiento y experiencia dentro del campo laboral. Esto no solo mejoraría la tasa de empleo, sino que también promovería puestos de trabajo en un largo plazo para el sector laboral en Ecuador, fortaleciendo la capacidad del ser humano para enfrentar desafíos futuros y adaptarse a los cambios del campo laboral.
Antiseizure medications for neonatal seizures: Insights from ILAE guidelines
Authors: Alghamdi Faisal , Almalki Eyad , Pathan Aslam , Farag Medhat , Arif Jamal , Aamir Meezab E Rehma
Published: February 2025

The International League Against Epilepsy (ILAE) has made significant efforts to standardize the management of neonatal seizures by providing evidence-based recommendations for antiseizure medication in neonates. This is important because managing seizures in neonates can be complex, and evidence-based guidelines help clinicians provide the best care. There were six main recommendations. The phenobarbital should be the first- line antiseizure medication regardless of etiology, unless channelopathy is likely the cause for seizures (e.g., due to family history), in this case phenytoin or carbamazepine should be used. Among neonates with seizures not responding to first-line antiseizure medication phenytoin, levetiracetam, midazolam, or lidocaine may be used as a second-line antiseizure medication. In neonates with cardiac disorders, levetiracetam may be the preferred second-line antiseizure medication. This article provides guidelines and consensus-based recommendations for six priority questions related to neonatal seizure management: (1) first-line antiseizure medication, (2) second-line antiseizure medication, (3) duration of antiseizure medication treatment, (4) impact of therapeutic hypothermia on seizure burden in neonates with hypoxic-ischemic encephalopathy (HIE), (5) impact of electrographic seizure treatment on outcome, and (6) administration of pyridoxine.
Operações em edificações com energia solar: riscos e cuidados necessários
Authors: Oliveira João Paulo de
Published: February 2025

A crescente adoção de sistemas fotovoltaicos exige uma análise detalhada dos riscos envolvidos, especialmente para os bombeiros militares que atuam em situações de emergência. Nesse sentido, o presente estudo buscou identificar os riscos estruturais e elétricos associados a esse sistema, bem como propor medidas mitigatórias e Procedimentos Operacionais Padrão (POP) para garantir maior segurança durante as operações de combate a incêndios, resgate e salvamento. Para tanto, foram realizadas visitas “in loco” e análises dos principais riscos inerentes à instalação e funcionamento dos sistemas fotovoltaicos em edificações residenciais, comerciais e industriais nas Cidades de Londrina e Prananavaí, Paraná. Os resultados evidenciaram que a sobrecarga estrutural pode comprometer a integridade das edificações, especialmente em construções não projetadas para suportar o peso adicional dos arranjos. Além disso, verificou-se que a geração contínua de eletricidade, mesmo após o desligamento do sistema, representa um risco significativo de choques elétricos e incêndios. Dessa forma, verifica-se a necessidade de criação de protocolos de segurança, específicos, voltados a segurança dos bombeiros militares durante operações em edificações com sistemas fotovoltaicos. Por fim, o estudo contribui para a adoção de medidas preventivas e normativas que minimizem os riscos e garantam uma resposta mais eficiente em situações emergenciais.
Cardio-metabolic effects of apremilast in patients with psoriatic arthritis: a prospective cohort study
Authors: Hansildaar Romy , van Geel Eva H. , Çoban Fatih , Dijkshoorn Bas , Heslinga Maaike , Bos Reinhard , Korteweg Mies A. , van Kuijk Arno W.R. , Nurmohamed Michael T.
Published: February 2025

Objective

Psoriatic arthritis (PsA) is associated with metabolic and cardiovascular disease. Studies have suggested that treatment with apremilast is associated with weight loss and other cardio-metabolic benefits. This study aimed to examine the effects of apremilast on body weight, body composition and cardiovascular risk factors in PsA patients.

Methods

This longitudinal, non-randomized, multicenter trial included adults with active PsA initiating apremilast (30 mg twice daily after a step-up regime). Patients were followed for 12 months, measurements were done at baseline and repeated at 26 and 52 weeks. Body composition, the primary outcome, was assessed using Dual Energy X-ray Absorptiometry (DEXA). Secondary outcomes included disease activity (DAS28-CRP), blood pressure, lipids, intima media thickness and glucose. Statistical analysis involved mixed models adjusted for relevant covariates.

Results

44 patients were included, with mean age 56 years (±SD, 11 years) and median BMI of 28 kg/m2[range 24-33]. 17 patients completed the study, while 27 discontinued due to ineffectiveness or side effects.

After one year of apremilast significant reductions were observed in multiple body mass parameters, including total fat (-7.4 kg; p=0.005) and android fat (1.1 kg; p=0.002). Lean mass remained stable.

Blood pressure showed minor reduction, while lipids, intima media thickness, and glucose levels did not change. Disease activity improved, with a significant decrease in DAS28-CRP (-0.6; p=0.02). Android fat correlated most strongly with disease activity reduction (r=0.312; p=0.004)

Conclusion

This study demonstrates that apremilast reduces fat mass in PsA patients and suggests beneficial cardiovascular and metabolic effects, potentially reducing the risk for cardiovascular events.
Risk of Mortality of people with Psoriasis and Psoriatic arthritis in Taiwan: A Nationwide Cohort Study
Authors: Wang Charmaine Tze May , Huang Jing-Yang , Liao Pei-Lun , Wei James Cheng-Chung , Leung Ying Ying
Published: February 2025

Objective

Residual confounding effects and disease severity attributed to controversial results in studies of psoriatic disease (PsD) and mortality. We aimed to evaluate the risk of mortality in incident PsD patients, compared to a matched controls from the population.

Methods

We used the nationwide, population-based insurance claim datasets in Taiwan from 2010-2018. Incident cases of PsD were identified by ICD codes. A non-exposed cohort was established through propensity score matching. Deaths were identified via the National Mortality Database. We evaluated the risk of all-cause mortality in PsD compared to the propensity score matched (PSM) non-exposed individuals using COX regression. The mortality risk was evaluated in patients with more severe disease stratified by systemic therapies use and having Psoriatic arthritis (PsA).

Results

108,642 incident PsD (40.17% women) and equal number of PSM matched non-PsD individuals were identified. Compared to the age and sex matched controls, there was a higher risk of mortality among patients with PsD (adjusted HR=1.73, 95% CI: 1.68-1.77, p<0.0001). After propensity score matching, we found an attenuated but persistent higher risk of mortality in PsD compared to controls (adjusted HR=1.20, 95% CI: 1.16-1.24). There was a trend of higher mortality in patients exposed to biologic therapies, but not for PsA.

Conclusion

There was an increased risk of all-cause mortality in individuals with PsD compared to non-PSD individuals before and after propensity score matching and adjustment for co-morbidities. The risk of mortality was higher in patients with PsO but not in patients with PsA as compared to controls.
Gailtal Slovene in Urban Jarnik’s Letters to Primic and Kopitar, 1811–1814
Authors: Pronk Tijmen
Published: February 2025

The paper presents the dialectal data from the Gailtal in Carinthia that Urban Jarnik discusses in his letters to Primic and Kopitar. Jarnik’s discussions of his native dialect in these letters could be regarded as the first serious treatment of Slovene dialectal material. The first part of the paper is devoted to a philological and phonological analysis of Jarnik’s data. The second half gives a glossary of all the Gailtal Slovene words in Jarnik’s letters. Many dialectal words that Jarnik gives are not attested in later literature.
Resian Pëňt’/Pëgnt’ ‘Stone, Cliff’
Authors: Hamp Eric P.
Published: February 2025

Etymology of Resian dialect (Slovene) Pëňt’/Pëgnt’ ‘Stone, Cliff’.
Des raisons de ne pas aimer Flaubert
Authors: Samoyault Tiphaine
Published: February 2025

Aimer Flaubert semble aller de soi. Pourtant, des écrivains, des philosophes l’ont régulièrement pris pour adversaire et ont pu avoir des raisons de ne pas aimer Flaubert. L’article s’intéresse aux diverses motivations de ce désamour, quand Flaubert devient le nom de ce à quoi on s’oppose : le réalisme, le formalisme ou l’esthétique… Ne pas aimer Flaubert revient à ne pas aimer l’idée de littérature qu’il représente pour d’autres. Après une confrontation des principales oppositions (Sartre, Sarraute, Bourdieu), l’article montre finalement comment ces attitudes défensives résonnent avec toutes les façons qu’on a d’aimer Flaubert.
Matching Community Sports Facilities With Ant Colony Algorithm in National Fitness
Authors: Chen Peng , Tian Tian
Published: February 2025

This study addresses the challenge of selecting optimal locations for urban sports facilities, leveraging the strengths of the ant colony optimization (ACO) algorithm. An enhanced ACO model is proposed, incorporating population density and distance to sports facilities as critical factors in the objective function. The model employs a unique pheromone updating strategy that reduces search time and improves solution quality. Two updates to the pheromone levels are performed, and the initial pheromone distribution is reset based on path distances. The effectiveness of the model is demonstrated through a case study in Yuhua District, Changsha City, where it successfully identifies prime locations for public sports facilities. This research contributes to the literature on facility siting and urban planning by offering a practical solution for optimizing the distribution of sports infrastructure within cities.
Travel Best Route Recommendation Algorithm Using Social Networks and Interest Hotspots Map
Authors: Zhang Yujuan
Published: February 2025

The algorithm proposed in this paper was a travel route recommendation algorithm based on social networks. The algorithm can reduce the time of route analysis and improve the accuracy of route analysis. Through the investigation and research of the best travel route recommendation algorithm based on social networks and interest hotspots, the results showed that before using the travel route recommendation algorithm based on social networks, tourists' satisfaction with travel time, travel route and tourism attraction was 87.25 points, 86.84 points and 88.62 points respectively. After using the travel route recommendation algorithm, tourists' satisfaction was 95.76 points, 96.48 points and 92.89 points respectively. These results can showed that the travel route recommendation algorithm can improve the satisfaction of tourists, and that the research of travel route recommendation algorithm based on social networks and interest hotspots map was of practical value. This also provided a new research path for tourism route recommendation technology.
Interactive Learning Environments
Authors: Dou Anqi , Xu Wei , Xu Liwen
Published: February 2025

With the rapid development of information technologies, Mobile Instant Messaging (MIM) has been widely applied to education, exerting a far-reaching influence on interactive learning environments. This study, employing a systematic review according to PRISMA protocol, aims to comprehensively and rigidly analyze the effect of MIM on interactive learning environments, including the advantages, challenges, and future trends. Reviewing previous research, this study finds that MIM can not only promote synchronous interactions between teachers and students but also enhance the flexibility and autonomy of learners, coupled with rich teaching strategies and plentiful learning resources. However, there are also challenges in using MIM, e.g. information overloads, technological over-reliance, cybersecurity, etc. This study provides constructive suggestions for educators, researchers, and practitioners to improve interactive learning environments.
Optimizing Centralized Inventory Systems Using Lateral Transshipments
Authors: Fadwa Elleuch
Published: February 2025

This study explores the optimization of centralized inventory systems through lateral transshipments, addressing supply chain disruptions caused by unpredictable demand. Lateral transshipments, which involve reallocating stock among retailers at the same distribution level, were investigated as a cost-effective and service-enhancing alternative to traditional emergency restocking methods. Using simulation and optimization techniques, we analyzed various transshipment policies, including Complete-Pooling and Partial-Pooling, across multiple scenarios. Our findings highlight that Partial-Pooling with an optimized threshold outperformed other policies by balancing collaboration and efficiency, reducing total costs, and improving service levels. The results underscore the importance of hybrid transshipment strategies, particularly for high-demand and cost-sensitive inventory systems. The research provides actionable insights for supply chain managers how tailored transshipment policies enhance centralized system overall supply chain resilience, profitability, and customer satisfaction.
Research on the Relationship Between Digital Marketing and Corporate Performance
Authors: Zhang Lan , Guo Yucen , Li Bingze , Yao Meifang , Maio Murong , Wu Chia-Huei
Published: February 2025

In the era of the digital economy in which disruptive information technologies such as artificial intelligence, blockchain, big data, and cloud computing prevail, digital marketing is increasingly becoming the focus of common attention in practice and academia. In this paper, companies listed on the GEM from 2019 to 2023 are selected as research samples to empirically test the impact and intrinsic role of digital marketing on enterprise performance. The results show that digital marketing significantly stimulates enterprise performance, and its incentive effect is mainly reflected in strategic innovation rather than substantive innovation. It is still valid after a series of endogeneity and robustness tests such as instrumental variable method and propensity score matching method. Based on the new perspective of information dynamic capability, this study opens the “black box” of digital marketing enabling enterprise performance and providing certain enlightenment for enterprises to effectively realizing the “win-win” of digital transformation and innovation ability improvement.
Prevalence and Determinants of Ischemic Heart Disease in the Elderly Population of India: A Cross-Sectional Study
Authors: Yellapantula Balsubramaniam , Jude Datta Sheshrao , Bhrushundi Milind , Sharma Ranjana
Published: February 2025

ABSTRACT

Background:

Ischemic heart disease (IHD) is a major cause of illness and death among the elderly in India. This study assessed the prevalence and risk factors of IHD in an elderly rural population.

Methods:

A cross-sectional study at Acharya Vinoba Bhave Rural Hospital, Wardha, India, from 2022 to December 2023, included 168 participants aged 60 and above. Data were gathered through questionnaires, exams, and lab tests. Multivariate logistic regression identified IHD determinants.

Results:

IHD prevalence was 44.6%. Hypertension, dyslipidemia, and diabetes were significant factors. Hypertension (OR 3.5), diabetes (OR 2.8), and dyslipidemia (OR 2.9) were key independent determinants.

Conclusion:

High IHD rates among the elderly highlight the need for targeted interventions addressing modifiable risk factors. Routine cardiovascular risk assessments are essential for reducing IHD in this population.
Advanced Therapeutic Applications of Algae in Combatting Infectious Diseases: Antimicrobial, Immunomodulatory, and Anti-inflammatory Approaches
Authors: Thitame Sunil N. , Aher Ashwini A.
Published: February 2025

ABSTRACT

Algae are photosynthetic organisms belonging to diverse groups, which have received much interest recently due to their anti-infective properties. These organisms synthesize bioactive compounds that exhibit considerable antimicrobial, immunomodulatory, and anti-inflammatory activities. In this paper, we review evidence on the potential of algae in modifying infectious pathogens, with particular emphasis on the antimicrobial ability of algae against bacteria, fungi, and viruses, as well as their ability to regulate immune responses and inflammation. Algae with conventional antibiotics may be useful for proposing a new strategy for combatting infectious diseases.
Pioneering Full Mouth Rehabilitation with Zygomatic Implants using full Digital work flow: A Case Report with 3-Year Follow Up
Authors: Gupta Alka , Gedam Unnati , Pandey Shweta , Gupta Jaivrat , Chandwani Neelam
Published: February 2025

ABSTRACT

Full mouth rehabilitation using zygomatic implants has emerged as a transformative solution for patients with severe maxillary atrophy or insufficient bone quality, where traditional implant techniques are not feasible. Zygomatic implants, anchored in the zygomatic bone, provide a stable foundation for prosthetic reconstruction, bypassing the need for extensive bone grafting procedures. Digital technology enables precise diagnostics, virtual treatment planning, guided surgery, and the fabrication of highly accurate prostheses. This case report details a pioneering full mouth rehabilitation using zygomatic implants, implemented through a comprehensive digital workflow. Over a three-year follow-up period, we evaluate the clinical outcomes, prosthetic success, and patient satisfaction.
Molecular Docking and Pharmacokinetic Properties of Chrysin, Indole-3-carbinol, and Curcumin in the Biological Context of Plasmodium falciparum 3D7
Authors: Alothaid Hani
Published: February 2025

Background & objectives:
Plasmodium falciparum is a protozoan parasite that causes malaria in humans. It is considered the most deadly species of Plasmodium that infects humans. Research continues to focus on understanding the biology and genetics of Plasmodium falciparum to develop new tools, vaccines, and treatments aimed at reducing the global burden of malaria caused by this deadly parasite.

Methods: In this study, three active compounds—chrysin, indole-3-carbinol, and curcumin—were optimized using Gaussian16, and a molecular docking study was conducted against Plasmodium falciparum 3D7, along with an evaluation of pharmacokinetic properties.

Results: Molecular docking studies indicated that the chrysin compound exhibits a stronger binding affinity to selected receptors of Plasmodium falciparum compared to the other compounds. Additionally, in-silico ADME screening was used to predict the pharmacological characteristics of acetyl-CoA reductase inhibitors and their metabolites.

Interpretation & conclusion: The findings predict that the chrysin compound exhibits better affinity with Plasmodium falciparum proteins, suggesting that this compound can effectively interact with specific targets within the parasite. It also highlights the favorable electrostatic interactions that contribute to its pharmacological effectiveness as an acetyl-CoA reductase inhibitor.
Establishing pharmacy perceptions of e-learning format, design and development for general practice continuing professional development in Scotland
Authors: Flynn Angela , Park Victoria , Hamilton Peter , Zlotos Leon
Published: February 2025

Background: This study explores an important area for Continuing Professional Development in pharmacy education and digital learning. Increased demand has generated the necessity for reviewing e-learning module development that successfully meets user needs and learner experience.    
Objective: This study investigates learners’ perceptions of standard and segmented e-learning modules and their impact on learner experience to inform future healthcare educational module development.    
Methods: Semi-structured interviews were conducted with pharmacists (14) and pharmacy technicians (1) on the General Practice Clinical Pharmacist programme. Participants were randomised to either single or segmented module design. Fifteen interviews were conducted and data were thematically analysed.     
Results: The format allowed for expressing opinions regarding the experience of using the module and highlighted key issues. The analysis identified 125 codes, which resulted in nine themes: Navigation, Interactivity, Structure, Time, Presentation, Resource, Content, Actions and Language.    
Conclusion: Results reassure educational providers that e-learning modules suit standard or segmented formats. Findings imply that module format is less important than easy-to-use, well-structured modules with high-quality content. Constructive feedback provided potential improvements to usability, which will help focus future resources and development. More work is needed to explore the translation of learning into practice and the benefit of the segmented format for diverse or interprofessional learners.
El género épico y los Semina Rerum: de Lucrecio a Ovidio
Authors: Pégolo Liliana
Published: February 2025

El presente trabajo tiene como finalidad hacer una revisión del concepto de “género literario y/o discursivo”, particularmente en la Antigüedad grecolatina, con el fin de analizar la excedencia genérica del poema lucreciano De Rerum Natura (s. I a.C.), estimado como un ejemplo de la poesía didáctica en lengua latina. Los pasajes textuales del extenso poema epicúreo demostrarán la búsqueda de nuevas dimensiones épicas por parte de Lucrecio, que se afanó en producir poesía filosófica en latín, buscando hollar terrenos desconocidos para la lengua del Lacio. Asimismo, considerando De Rerum Natura como un “texto abierto”, se advertirá una dialéctica genérico-lingüística con autores posteriores, tales como Virgilio y Ovidio, quienes exhiben relaciones controversiales con la épica homérica tradicional en la Égloga 6 y en Metamorfosis, respectivamente.
Richard Wagner e o Brasil
Authors: Hunsche Carlos Henrique , Vidal (tradução e notas) João
Published: February 2025

Tradução do artigo “Richard Wagner und Brasilien” publicado no Ibero-Amerikanisches Archiv (do Ibero-Amerikanisches Institut de Berlim), n. 13, v. 3, 1939, p. 199–216, bem como das fontes primárias constantes em seu anexo.
Por uma musicologia culturalmente orientada: um depoimento de Antonio Alexandre Bispo
Authors: Vidal João , Rocha Edite
Published: February 2025

Entrevista concedida por Antonio Alexandre Bispo a João Vidal e Edite Rocha em novembro de 2024.
The Dynamics of Vulnerability, Agency and Mental Health Challenges among Students
Authors: Baron Jomarie V
Published: February 2025

ABSTRACT
Students in higher education face challenges stemming from academic, financial, and social stressors, which can have a significant impact on their mental health and well-being. However, the influence of students' vulnerability and agency on mental health has not been fully examined. This study aimed to investigate the relationships between vulnerability, agency, and mental health challenges among students at South Cotabato State College, focusing on academic, financial, and social dimensions. The study employed a descriptive-correlational design, with 280 students selected through stratified random sampling. The Spearman rank correlation coefficient was used to analyze the data. Results indicated a strong positive correlation between vulnerability and mental health challenges, suggesting that higher vulnerability levels are associated with greater mental health struggles. In contrast, agency showed a very weak negative correlation with mental health challenges, indicating that although students exhibited high levels of agency, it did not significantly reduce mental health issues. These findings imply the need for comprehensive support systems that address vulnerabilities, especially in academic, financial, and social contexts, while also considering students' agency in relation to broader environmental factors. It is recommended that educational institutions integrate targeted programs that mitigate vulnerability and support mental health without solely relying on individual attributes. Further research could expand on these findings by examining additional variables influencing student well-being.
Indexing Geopolitical World; Code Preference and Inscription at Old Town Semarang, Indonesia
Authors: Khasanah Nurul , Artawa Ketut , Purnawati Ketut Widya , Suryati Ni Made
Published: February 2025

ABSTRACT
Public sign at old town Semarang represents many variations of language. Besides, the history of old town Semarang offers something fresh perspective on Linguistic landscape due to Dutch colonialism. This study aims to analyze the signs and its relation with geopolitical world by considering government regulation and the purpose of the sign. This study used descriptive qualitative method. The study is phenomenological which is combinatorial, explanatory, and synchronic because the code preference and inscription used in public area (Bungin, 2017). The data were obtained through observation and documentation methods involving photography techniques. The data was analyzed using Scollon & Wong Scollon (2003). The result reveals three types of language used; mono/bi/multilingual form in 63 signs around old town Semarang with 15 different languages. All signs divided into four preferences. Among those signs, geopolitical effect was found through government’s regulation and it is indexing a power to set the public sign. Therefore, other signs were built by the sign maker for a commercial strategy. Despite the fact that the old town has Dutch history, English appeared as the most prominent language in the signs, indicating that language is not always in line with language protection and preservation goals.
On the heptadiagonal matrix CL factorization
Authors:   Department of Industrial Engineering and Logistics, National School of Applied Sciences of TANGIER, Talibi B. ,   Abdelmalek Essaâdi University, Morocco., HADJ A. AIAT ,   Regional Center of the Trades of Education and Training (CRMEF)-Tangier, Avenue My Abdelaziz, Souani, BP:3117, Tangier. Morocco., SARSRI D. ,   Department of Industrial Engineering and Logistics, National School of Applied Sciences of TANGIER; Abdelmalek Essaâdi University, Morocco.
Published: February 2025

The main contribution of this paper is a newCLtype decomposition of heptadiagonal matricesfor fast inversion. We further provide two algorithms and study their execution times to mea-sure the benefit of the proposed decomposition. Therefore, we are able to obtain a number ofinteresting results.
Intrinsic Motivation and Student Engagement in Classroom Learning Environment in A Selected School in China: Towards Classroom-Enhanced Learning Program
Authors:   Graduate School, Emilio Aguinaldo College, Siyu Liu
Published: February 2025

This descriptive quantitative research assessed the intrinsic motivation factors in classroom learning environment in a selected school in China in terms of autonomy, competence and relatedness; and learning engagement in terms of behavioral, cognitive and emotional. The respondents are the students at the School of Tourism of Changchun University Quota sampling was applied in the selection of the respondents. Data interpretation indicated that the students' overall motivational experience is positive and they generally feel motivated to engage in the learning process, driven by the opportunities for autonomy, the sense of competence, and the relationships they have in the classroom. The overall engagement score is positive, indicating that most students perceive themselves as engaged in their learning, combining efforts across the emotional, cognitive, and behavioral dimensions. The correlation analysis revealed that intrinsic motivation and engagement are closely interconnected, with competence playing a crucial role in fostering active participation and enthusiasm. The findings emphasize the need for targeted interventions to strengthen intrinsic motivation and engagement, particularly through strategies that address specific course-related challenges and capitalize on the strengths of various motivational dimensions.
Sustainability Accounting: Theoretical Integration and Approaches Conceptual
Authors:   Faculty of economics and business muhammadiyah university lamongan, . Andrianto
Published: February 2025

The acceleration of changes in practice and in scientific research in the field of sustainable development has not yet made it possible to clearly understand its role in science in the field of accounting. The research method is in the form of deductive and inductive reasoning accompanied by descriptive and comparative analysis, where this article provides an explanation of research studies on sustainability accounting from a theoretical and practical point of view based on research sourced from the web of science database from a period of time. time 2000 – 2020. The results of this research describe sustainability accounting which is carried out based on accounting theorization and describes the conceptual framework in scientific development in the field of accounting. The conceptual framework approach of sustainability accounting is able to complement the space shown in research based on accounting theorization. The aim of the sustainability accounting conceptual framework approach is to propose a structure, assumptions and objectives to ensure that stakeholders and external stakeholders have credible information on sustainable development performance.The findings of this research are in the form of a proposed conceptual framework as a basic element of a schematic approach to the integration of sustainability accounting objectives which is able to describe accounting tasks in an accountability system.
Exploring the Opportunities and Challenges of Artificial Intelligence in Healthcare: A Study of Healthcare Workers in Medical Institutions in Akure, Ondo State, Nigeria
Authors:   Business Administration and Management Federal Polytechnic, Ile Oluji. Ondo-State, Alli Kudirat O. , Adewale Adeola O. ,   Business Administration and Management Federal Polytechnic, Ile Oluji. Ondo-State, Akintajuwa Ademola O. ,   Business Administration and Management Federal Polytechnic, Ile Oluji. Ondo-State
Published: February 2025

A total of 200 health care workers (32 medical doctor, 77 nurses, 46 allied health e.g., physiotherapy etc., 30 administrative officers, and 15 others hospital officers). Outcomes revealed that healthcare workers generally have a strong awareness of AI technologies, with a majority believing in their potential to improve healthcare delivery with different standard deviation indicating variation in opinion (σ=0.71867, σ=1.18142, σ=0.83237, σ=0.83237.). Healthcare workers generally have a positive perception of AI's potential to improve patient care and healthcare delivery also with (σ=0.71867, σ=1.18142, σ=0.83237, σ=0.83237.). Healthcare workers express caution due to notable barriers, including the high financial costs of implementation, ethical concerns, resistance to change, and fears of job displacement. Finally, most healthcare workers are either supportive or neutral toward AI integration in medical practices, with a small group expressing reservations with (x= 4.1750, σ = 1.02451) indicating moderate variable. Overall, healthcare workers exhibited a positive outlook regarding the potential of artificial intelligence (AI) to enhance patient care and healthcare delivery. Nevertheless, the findings revealed notable gaps in the direct application of AI, divergent opinions on training requirements, and varying assessments of organizational preparedness. These results underscore the critical need for targeted education, robust capacity-building initiatives, and strategically planned implementation to facilitate the effective integration of AI technologies within the healthcare sector.
Response to the Comment on our Article: "Explosive is not a Term Defined in the International System of Units and Should not be Used to Describe Neuromuscular Performance"
Authors: Ide Bernardo , P. Silvatti Amanda , A. Staunton Craig , Marocolo Moacir , J. Oranchuk Dustin , R. Mota Gustavo
Published: February 2025

We thank Schumann et al. (Schumann, Feuerbacher et al. 2024) for their engagement and thoughtful comments on our article (Ide, Silvatti et al. 2023), and the overarching use of terminology in sports science. Academic debate is critical for advancing our field, and we welcome the opportunity to clarify and expand on our arguments. While their comment offers a perspective on practical terminology use, we maintain that the application of “explosive” in scientific literature may be both unnecessary and potentially misleading.
MANIFESTAÇÕES NEUROLÓGICAS POR DOENÇAS INFECTOCONTAGIOSAS
Authors: Camargo Pedro
Published: February 2025

Introdução: Nas décadas de 60 e 70, o Brasil enfrentava endemias de doenças infecciosas que eram comumente associadas à fome, desnutrição e falta de saneamento básico. Com isso, as políticas públicas impulsionaram a industrialização e a urbanização do país. Por volta de 2000, 50% da população ainda possuía boa qualidade de vida, como acesso à água e rede de esgoto. As principais doenças infectocontagiosas eram a febre amarela e doenças virais, gerando impactos, não somente sociais, mas também econômicos e políticos, sendo considerado um problema de saúde pública. Destacando doenças que provocam manifestações neurológicas, serão abordadas desde a hanseníase e a poliomielite, com alta incidência na população brasileira na década de 80, até doenças mais atuais, que assolam a saúde pública brasileira da década de 80 em diante, a epidemia de vírus da imunodeficiência humana (HIV), Zika vírus e COVID-19. Objetivo: Identificar as principais sequelas neurológicas causadas pela hanseníase, poliomielite, Zika vírus, HIV e COVID-19. Métodos: Revisão de literatura por meio de fontes secundárias a partir de buscas nas bases de dados da Scielo, Lilacs e MedLine/PubMed, de estudos publicados entre 2000 e 2024. Incluídos estudos que abordaram as manifestações neurológicas por agentes infecciosos. Resultados: Foram selecionados 20 estudos. As doenças consideradas antigas, hanseníase e poliomielite, possuem revisões atuais e estudos de casos a respeito de manifestações neurológicas. Doenças atuais, como Zika vírus, COVID-19 e HIV, carecem de estudos de caso e ensaios clínicos. No entanto, cerca de 70% dos autores trazem informações parecidas em relação às manifestações neurológicas, tais como paresias, alterações sensoriais e de tônus. Considerações finais: as doenças infecciosas geram sequelas heterogêneas.
Fragilidades e potencialidades na gestão e no uso racional de medicamentos no cuidado em longo prazo a idosos
Authors: Marques Polo Maria Victória , Ribeiro Mattar Damiance Patricia Ribeiro Mattar Damiance
Published: February 2025

Objetivo: este estudo buscou compreender a gestão e o uso racional de medicamentos junto aos responsáveis técnicos da área administrativa e da saúde, de uma residência de cuidado de longa permanência a idosos de natureza filantrópica, sob a perspectiva da promoção do uso racional de medicamentos. Método: a pesquisa foi desenvolvida por meio de entrevistas, da observação da dinâmica administrativa e de cuidado da residência, de visitas exploratórias e da análise documental de 68 registros de administração de medicamentos. A análise dos dados deu-se por meio de cálculos de frequência absoluta e relativa, da interpretação das respostas dos participantes e das informações obtidas com as visitas exploratórias. Resultados: os resultados encontrados nesta pesquisa apontam dissonâncias político-legais e normativas que impactam e fragilizam a percepção sanitária da relação entre polifarmácia, doenças crônicas e produção de resíduos sólidos e medicamentosos no cuidado a longo prazo a idosos. Conclusão: a incorporação dos princípios e das diretrizes da promoção do uso racional de medicamentos e das políticas públicas de gerenciamento de resíduos no regulamento técnico das residências para idosos se faz urgente. Tal incorporação deve visar a sustentabilidade financeira e ambiental, a organicidade e a racionalidade técnico-científica nos processos de gerenciar e de cuidar da pessoa idosa que vive fora do domicílio familiar.
Neural Network Model Using An Enhanced Whale Optimization Method For Cyber Threat Detection
Authors: Asra Sarwath  , Dr. Raafiya Gulmeher  , Zeenath Sultana
Published: February 2025

In our modern, highly-connected society, cybersecurity is of the utmost importance. With the rapid advancement and increasing integration of technology into our daily lives, the need of cyber security cannot be emphasized enough. Cybersecurity is vital for individual’s protection. Credential stuffing is a sort of cyber assault whereby attackers use previously obtained usernames, keywords and passwords to unlawfully invoke user accounts across many websites. This is plausible as many individuals utilize identical passwords and usernames across several websites. The proposed Enhanced Whale Optimization Algorithm Neural Network (EWOA-NN) model may address the issues of failure detection, prediction, and credential stuffing attacks. A unique optimization method called the neural network is trained using EWOA. After confirming the efficacy of the proposed attack identification model, we will conduct an empirical comparison with respect to certain security research.