bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure S6 from Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Authors: Linde Miles H. , Fan Amy C. , Köhnke Thomas , Trotman-Grant Aaron C. , Gurev Sarah F. , Phan Paul , Zhao Feifei , Haddock Naomi L. , Nuno Kevin A. , Gars Eric J. , Stafford Melissa , Marshall Payton L. , Dove Christopher G. , Linde Ian L. , Landberg Niklas , Miller Lindsay P. , Majzner Robbie G. , Zhang Tian Yi , Majeti Ravindra
Published: April 2023

TR-APC induction results in inflammatory rewiring of the tumor microenvironment.
Supplemental Figure S4 from Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Authors: Linde Miles H. , Fan Amy C. , Köhnke Thomas , Trotman-Grant Aaron C. , Gurev Sarah F. , Phan Paul , Zhao Feifei , Haddock Naomi L. , Nuno Kevin A. , Gars Eric J. , Stafford Melissa , Marshall Payton L. , Dove Christopher G. , Linde Ian L. , Landberg Niklas , Miller Lindsay P. , Majzner Robbie G. , Zhang Tian Yi , Majeti Ravindra
Published: April 2023

In vitro re-exposure of T cells from surviving mice demonstrates TR-APC-mediated generation of tumor-specific memory.
Supplementary Figure S3 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
Authors: Al-Jazrawe Mushriq , Xu Steven , Poon Raymond , Wei Qingxia , Przybyl Joanna , Varma Sushama , van de Rijn Matt , Alman Benjamin A.
Published: April 2023

Type B (mutant) cells exhibit higher alpha-smooth muscle actin levels at the protein and RNA level.
Supplementary Figure S2 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
Authors: Al-Jazrawe Mushriq , Xu Steven , Poon Raymond , Wei Qingxia , Przybyl Joanna , Varma Sushama , van de Rijn Matt , Alman Benjamin A.
Published: April 2023

Detection of potential morphological differences between colonies derived from the same desmoid tumor primary culture sample
Supplementary Figure S11 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
Authors: Al-Jazrawe Mushriq , Xu Steven , Poon Raymond , Wei Qingxia , Przybyl Joanna , Varma Sushama , van de Rijn Matt , Alman Benjamin A.
Published: April 2023

Histologic appearance of two cases of desmoid tumors with different patterns of CD142 expression
Supplementary Figure S10 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation
Authors: Al-Jazrawe Mushriq , Xu Steven , Poon Raymond , Wei Qingxia , Przybyl Joanna , Varma Sushama , van de Rijn Matt , Alman Benjamin A.
Published: April 2023

Densitometry of selected secreted proteome from mutant and non-mutant conditioned media
Blood Biomarkers for Healthy Aging
Authors: Ubaida-Mohien Ceereena , Tanaka Toshiko , Tian Qu , Moore Zenobia , Moaddel Ruin , Basisty Nathan , Simonsick Eleanor M. , Ferrucci Luigi
Published: April 2023

Measuring the abundance of biological molecules and their chemical modifications in blood and tissues has been the cornerstone of research and medical diagnoses for decades. Although the number and variety of molecules that can be measured have expanded exponentially, the blood biomarkers routinely assessed in medical practice remain limited to a few dozen, which have not substantially changed over the last 30–40 years. The discovery of novel biomarkers would allow, for example, risk stratification or monitoring of disease progression or the effectiveness of treatments and interventions, improving clinical practice in myriad ways. In this review, we combine the biomarker discovery concept with geroscience. Geroscience bridges aging research and translation to clinical applications by combining the framework of medical gerontology with high-technology medical research. With the development of geroscience and the rise of blood biomarkers, there has been a paradigm shift from disease prevention and cure to promoting health and healthy aging. New -omic technologies have played a role in the development of blood biomarkers, including epigenetic, proteomic, metabolomic, and lipidomic markers, which have emerged as correlates or predictors of health status, from disease to exceptional health.
A Second Ductoscopy Procedure in Patients with Recurrent and Persistent Pathological Nipple Discharge
Authors: Makineli Seher , Filipe Mando D. , Vriens Menno R. , van Diest Paul , Witkamp Arjen J
Published: April 2023

Background: Most patients suffering from pathological nipple discharge (PND) undergo local surgical procedures because standard radiological imaging often fails to reveal the cause. Ductoscopy is a minimally invasive endoscopic technique that enables direct intraductal visualization and can avoid unnecessary diagnostic surgical procedures. Hence, patients with recurrent or persistent PND after an unsuccessful ductoscopy procedure still undergo unnecessary surgery. This study describes the experience of a second ductoscopy procedure in patients with recurrent or persistent PND without suspicious radiological findings. Methods: Patients with recurrent or persistent PND who underwent two ductoscopy procedures between 2010 and 2017 were retrospectively analyzed. The second ductoscopy was performed when the first ductoscopic attempt was unsuccessful due to technical problems. The primary outcome was the number of preventable surgical procedures. Results: A total of 17 patients underwent two ductoscopy procedures. The first ductoscopy showed a polypoid lesion in 10 patients (58.8%), no abnormalities in 3 patients (17.6%), and in 4 patients (23.5%), it was not possible to visualize the ductal tree. Post-procedure, all patients suffered from PND. After two ductoscopic attempts, PND stopped in 10 patients (58.8%), and 7 patients (41.2%) still suffered from PND and were operated on. Pathology of the resection specimens showed no abnormalities in 1 patient, a papilloma in 5 patients, and ductal carcinoma in situ in 1 patient. Conclusion: A second ductoscopy procedure can be considered in the diagnostic work-up of patients suffering from persistent or recurrent PND after an unsuccessful first ductoscopic attempt to avoid unnecessary surgery in about 59% of the cases.
Mulheres na academia: desigualdades de gênero no corpo docente da Faculdade de Direito da USP
Authors:   Universidade de São Paulo. Faculdade de Direito, Campos Isabelle Oglouyan de
Published: April 2023

A presente pesquisa empírica buscou investigar as desigualdades de gênero no corpo docente da Faculdade de Direito da Universidade de São Paulo para testar hipóteses sobre a dificuldade de ingresso e ascensão das mulheres aos cargos de professoras doutoras, associadas e, finalmente, titulares. Apesar de as alunas representarem aproximadamente 41% do número total de estudantes, as mulheres são apenas 18% do corpo docente. Nesse sentido, foram analisados os concursos de ingresso, livre-docência e titularidade na faculdade, no período entre 2008 e 2017, para verificar se o reduzido número de mulheres no corpo docente da faculdade é resultado das características de seu processo seletivo.
Abstract 9361: Interleukin-33 System as Potential Biomarker and Therapeutic Target in Kawasaki Disease
Authors: Okada Seigo , Yasudo Hiroki , Ohnishi Yuji , Matsuguma Chie , Fukano Reiji , Waniishi Takako , Hasegawa Shunji
Published: April 2023

Introduction:
Kawasaki disease (KD) is an acute, self-limiting, febrile systemic vasculitis of unknown cause associated with the development of coronary artery lesions (CALs) during childhood. Damage-associated molecular patterns (DAMPs) from cell death and oxidative stress have been shown to be involved in the development of KD vasculitis. Interleukin (IL)-33 is released from damaged endothelial cells and acts as DAMPs.

Hypothesis:
IL-33 and its receptor (ST2) might be involved in KD pathogenesis.

Methods:
Serum levels of soluble ST2 (sST2) in KD patients were measured before their first therapy. Furthermore, we investigated the impact of IL-33 on human coronary artery endothelial cells (HCAECs) and human coronary artery smooth muscle cells (HCASMCs).

Results:
Serum levels of sST2 were significantly higher in KD patients with CALs than in those with normal coronary arteries (87.2 [18.4-224.0] ng/mL vs. 31.7 [8,8-290.3] ng/mL,
p
= 0.017).
In vitro
, IL-33 upregulated the expression of ST2L and increased production of sST2, IL-6, IL-8, and monocyte chemoattractant protein–1 in HCAECs in a time- and concentration-dependent manner. Notably, compared to isoconcentration of tumor necrosis factor-α (TNF-α), IL-33 significantly increased IL-6 production; 10 ng/mL of IL-33 increased the production of IL-6 by 13-fold compared with that by TNF-α (9.1 ng/mL vs. 0.7 ng/mL,
p
< 0.05). Moreover, IL-1β increases IL-33 production by HCASMCs in a concentration-dependent manner.

Conclusions:
The results of the present study suggest that the IL-33/ST2 axis might be involved in the development of KD vasculitis. The IL-33/ST2 axis may be a therapeutic target for the treatment of KD.
International Institutions and Information Technologies: Transformations for a Higher Order System
Authors: Gordon Geoff
Published: April 2023

This contribution focuses on the interoperation of analogue and digital information technologies (and techniques associated with them), to ask how their interoperation has determined (and changed) what is made legible in practices associated with international institutions. It traces how the interoperation of digital and analogue technologies has supported the intensification of efficiency-maximizing institutional routines, now expressed in the so-called optimization function associated with neural networks and artificial intelligence. As a result, the terrain of contestation has shifted in significant ways from arguments over rules to pattern-recognition processes that determine efficient solutions according to optimal outcomes. Institutional practice on this new terrain aspires to a sort of immediacy, a direct engagement in the becoming of the thing(s) to which the institutional mandate may apply. This immediacy defies the reflective character associated with traditional legal practice, and assumes power by defining problems and engendering governance issues in the very act of addressing them.
International Law as a Cyborg Science
Authors: Haskell John D.
Published: April 2023

International law academics have increasingly turned to engage deliberately engage computer-oriented technologies. There is little work in the literature that reflects on how this engagement itself takes place, what it tells us about the state of the discipline, and the consequences of concentrating on the phenomena of digital technologies. This paper shares some possible conceptual taxonomies and theoretical concerns in disciplinary self-reflection about our digital futures.
Decision Making in Asylum Law and Machine Learning
Authors: Arvidsson Matilda , Noll Gregor
Published: April 2023

This article avails an autoethnography of the authors’ attempt to construct a post hoc intervention machine learning (ml) system responsive to the problem of discrimination in asylum law decisions. In the article we revisit the conjunction of law as a slow hermeneutic, against the fast-paced pull of ai and commercial imperatives to ask whether a ml-driven post hoc intervention system such as the one set up in the research project reduces the overall risk of discrimination emerging from human discretion in legal decision making on asylum. We conclude that a ml-driven ‘anti-discrimination machine’ will displace rather than reduce that overall risk. We warn that similar attempts at using ml as part of legal decision making, decision support, and post hoc interventions, in international law and beyond, may need to take seriously the risks of human discretion embedded in ml design and data selection.
Subjecthood in Cyberspace and the Uncanny Valley of International Law
Authors: Korhonen Outi , Bruncevic Merima , Arvidsson Matilda
Published: April 2023

In this article the authors build on Masahiro Mori’s 1970s essay “The Uncanny Valley”, psychoanalysis and critical legal pluralism, to analyse how the uncanny in international law is exposed through law’s encounter with the a-human, non-human and more-than-human phenomena challenging legal subjecthood in cyberspace. Discussing autonomous decision-making, dwellers and encounters in international law’s uncanny valley the article proposes that international law needs to cater to a spectrum of non-human subjectivities, entities, laws and normativities. In short, international law needs to ‘get over itself’ and its constant anxiety in the face of the plurality of laws and Others.
Now You See Them, Now You Don’t
Authors: Murphy Sean D. , Parkhomenko Yuri
Published: April 2023

One intersection between scholarship and practice in international humanitarian law is observable in international litigation concerning violations of the law of war. An interesting example in this regard recently arose in the case by the Democratic Republic of the Congo against Uganda for war-related claims. At the reparations phase, the Court decided not to rely solely on the submissions of the Parties, but to task certain scholars and other experts to answer evidentiary questions. Yet, when the Court’s judgment was issued in February 2022, the role of these experts turned out to be almost negligible, with one significant exception. The overall lesson may be that – while the work of scholars can be highly important for claims practice relating to international humanitarian law – it has its limits, such as when proving and quantifying mass civil injury resulting from a lengthy and complex armed conflict.
A Study on the Conceptual Structure of the Use of Prepositions in the Complement of Goal-oriented Motion Verbs in Brazilian Portuguese
Authors: Gil Maitê Moraes , Soares da Silva Augusto
Published: April 2023

This study aims at understanding the conceptual structure of the use of prepositions (a ‘at’, para ‘to’, em ‘in’) in the complement of goal-oriented motion verbs (ir ‘go’, vir ‘come’, chegar ‘arrive’) in Brazilian Portuguese. Applying a corpus-based and profile-based methodology, within a Cognitive Grammar framework, this study combines a multifactorial usage-feature analysis of these prepositional constructions with their subsequent multivariate statistical modeling. The results point out the cognitive basis of this constructional variation and specifically show that the semantic features ‘profiling’ and ‘motion verb’ are the most important language-internal predictors in the use of the prepositions. This variation conveys alternative grammatical construals, i.e., the very high frequency of em ‘in’ in the complement of goal-oriented motion indicates nuances of meaning motivated by the superimposition of image schemas and the cognitive operation of profiling. Language-external features, such as register, also play a role in the variation.
The Poetics of Pain
Authors: Holst-Warhaft Gail
Published: April 2023

Modern Greek poetry has been influenced by a tradition of lament that is still practiced in rural Greece, and by the tragic events of modern Greek history. In contrast to the elegiac tradition, laments and their women practitioners ascribe a positive value to pain. Male poets of the generation of 1930 made use of the imagery of folk lament in their poetry, and women poets of the second half of the 20th century addressed the dead directly as their village counterparts still do. The Asia Minor catastrophe of 1922 dominated 20th-century modern Greek literature and drew on another traditional poetic form, the “lament for lost cities.” More recently, songwriters have mourned the political and economic tragedies of contemporary Greece in lyrics that seem much closer, in their expression of pain, to the tradition of lament than to elegy.
The Words of Facts: How British and Italian Students Use in Fact in Academic Writing
Authors: Ackerley Katherine , Gesuato Sara
Published: April 2023

This study examines the frequency, meanings, lexico-grammatical and discursive features of the pragmatic marker in fact in an L1 subcorpus of the British Academic Written English corpus and in a learner corpus of essays written by Italian university students. One of four meanings, ‘contrast’, ‘specification’, ‘factuality’ and ‘support’, was assigned to each instance of in fact in both corpora. Similarities and differences emerged in the use of this pragmatic marker. All four meanings are present in both corpora; however, the ‘contrast’ and ‘specification’ meanings occur more often in the L1 corpus, while the ‘factuality’ and ‘support’ meanings occur more often in the L2 corpus. These findings suggest that the Italian learners are not fully aware of the multiple meanings of in fact.
Predicting Airflow from Measures Sensitive to Mid-cord Glottal Gap During the COVID-19 Pandemic
Authors: Niermeyer Weston , Diao Guoqing , Bielamowicz Steven A. , Stager Sheila V.
Published: April 2023

Objectives:

To determine if trans-laryngeal airflow, important in assessing vocal function in paresis/paralysis and presbylarynges patients with mid-cord glottal gaps, could be predicted by other measures sensitive to mid-cord glottal gap size but with smaller risks of spreading COVID-19, and if any patient factors need consideration.

Methods:

Four populations were: unilateral vocal fold paresis/paralysis (UVFP, 148), aging and UVFP (UVFP plus aging, 22), bilateral vocal fold paresis/paralysis without airway obstruction (BVFP, 49), and presbylarynges (66). Five measures were selected from the initial clinic visit: mean airflow from repeated /pi/ syllables, longer of 2 /s/ and 2 /z/ productions, higher of 2 cepstral peak prominence smoothed for vowel /a/ (CPPSa), and Glottal Function Index (GFI). S/Z ratios were computed. Stepwise regression models used 3 measures and 5 patient factors (age, sex, etiology, diagnosis, and potentially impaired power source for voicing) to predict airflow.

Results:

Log-transformations were required to normalize distributions of airflow and S/Z ratio. The final model revealed age, sex, impaired power source, log-transformed S/Z ratio, and GFI predicted log-transformed airflow ( R2 = .275, F[5,278] = 21.1; P < .001).

Conclusions:

The amount of variance explained by the model was not high, suggesting adding other predictive variables to the model might increase the variance explained.
Flourishing, psychological distress and internalized stigma among parents of an adult son or daughter with schizophrenia
Authors: Dimitriou Loukia , Chiu Marcus , Carson Jerome
Published: April 2023

Background:

Parents of adults diagnosed with schizophrenia, have been reported to have higher levels of psychological distress than the general population, and parents whose offspring have other mental or physical illnesses.

Aim:

This study examines the comparatively new construct of flourishing, and its relationship to internalized stigma and psychological distress.

Method:

A cross-sectional survey was conducted between July 2021 and March 2022, with an international sample of 200 parents of adult sons or daughters diagnosed with schizophrenia. Participants completed a demographic questionnaire and three standardized inventories. These were the PERMA Profiler, which measures flourishing, the CORE-10, which measures psychological distress, and a new parental Internalized Stigma Scale. Sample characteristics of individuals of schizophrenia and their parents were examined using descriptive statistics, and the contributing factors affecting stigma were assessed through regression analysis.

Results:

The initial hypothesis that parents scoring high on internalized stigma, would have significantly higher levels of psychological distress and lower levels of flourishing, than parents with low-level internalized stigma, was confirmed. Overall, the flourishing levels were lower and psychological distress higher in these parents, than those of the general population. Regression analysis identified psychological distress and hopefulness as the two major predictors of flourishing, though in different directions. Interestingly, stigma did not determine flourishing, in spite of their close relationship.

Conclusions:

Researchers have long been aware of internalized stigma in persons with schizophrenia. Yet this study is one of the few that linked it with parents of adults with schizophrenia and flourishing and psychological distress. Implications were discussed in the light of the findings.
Evaluation of parent bonding style and traumatic experiences in patients with schizophrenia and bipolar disorder: A case-control study
Authors: Gomes Liliana , Ferreira Tania , Santos Emanuel , Freitas Joana , Carvalho Rafael
Published: April 2023

Background:

There is no consensus about the etiology of schizophrenia (SQZ) and bipolar disorder (BD). Both hereditary and environmental factors are recognized, but the importance of variables like the role of parental attachment and trauma is still under research.

Aims:

Evaluate and compare the patient-parent bonding and the frequency and severity of various types of trauma in patients with SQZ, BD, and a control group from Primary Health Care.

Method:

This study included 50 patients with SQZ and 50 with BD followed at a psychiatric hospital, through a convenience sample. Each participant of the clinical sample was paired with a control with no psychiatric background of the same gender and similar age, from a primary health center. Two scales were applied – Parental Bonding Instrument (PBI) and Childhood Trauma Questionnaire – Short Form (CTQ-SF).

Results:

Regarding PBI, there was a higher frequency of the most dysfunctional attachment style (affectionless control), in patients with SQZ and BD, with p < .001 (always), both for the father and the mother. In addition, ideal parenting style (optimal parenting) was significantly more common in control samples, with p = .002 or <.001, both for the father and for the mother. Trauma was more frequent and severe in SQZ and BD than controls, in all evaluated dimensions. Again, differences between groups are obvious, with p = .012 or <.001. Parental bonding style and scores in the care and overprotection dimensions were also correlated. The only parental bonding style in which correlations were found was in affectionless control. Correlations were more common in cases of neglect compared to abuse.

Conclusions:

In this research we found important differences in terms of parental attachment and childhood trauma between patients with SQZ and BD, compared with controls of the same gender and age.
Disability Is Not a Burden: The Relationship between Early Childhood Disability and Maternal Health Depends on Family Socioeconomic Status
Authors: Bixby Laurin E.
Published: April 2023

Narratives rooted in ableism portray disabled children as burdens on their families. Prior research highlights health disparities between mothers of disabled children and mothers of nondisabled children, but little is known about how socio-structural contexts shape these inequities. Using longitudinal data from the Future of Families and Child Wellbeing Study (n = 2,338), this study assesses whether the relationship between early childhood disability and maternal health varies by household socioeconomic status (SES). Findings reveal that, on average, mothers of children disabled by age five report worse health than mothers of nondisabled children; however, this pattern is only evident among lower SES mothers and disappears for higher SES mothers. Contextualizing the findings within the systemic ableism literature highlights how—instead of portraying disabled children as burdens on their families—scholars and policymakers should focus on how ableism and poverty burden disabled people and their families in ways that pattern health risks.
What Future for the Sociology of Futures? Visions, Concepts and Methods
Authors: Halford Susan , Southerton Dale
Published: April 2023

Questions about the future, and futurelessness, have attracted wide-ranging attention in recent years. Our article explores what Sociology offers. We reflect on the apparent contradiction that the future was bracketed off from the discipline in its early history, yet also offers rich theoretical, methodological and empirical resources for futures research. We demonstrate this through an analysis of the contributions to this Special Issue, each of which draws on explicitly Sociological theories and methods to consider futures in a range of fields. Finally, we explore further developments necessary for a Sociology of the Future. We argue that Sociology can and should be more directly involved in claiming what futures might be, should be and in materialising these claims. This means moving beyond Sociology – as a distinct set of resources – towards expansive engagement with other future-making actors. This may challenge and change Sociology but may also be key to its future.
Longitudinal QCA: Integrating Time Through Change-Based Intervals (CBIs) and a Flexible Lag Condition (FLC)
Authors: Niessen Christoph
Published: April 2023

In the wake of the methodological developments that aim to render qualitative comparative analysis (QCA) “time sensitive”, I propose a new procedure for carrying out QCA longitudinally. More specifically, I show first why longitudinal case disaggregation should be carried out with change-based intervals (CBIs) rather than with fixed intervals. Second, I develop a flexible lag condition (FLC) that (i) resolves two types of temporal contradictions and outcome redundancies that can result from temporal case disaggregation and (ii) allows to measure the average duration it takes for a combination of conditions to translate to an outcome. Since temporal contradictions and outcome redundancies are most likely with an increasing number of time points and conditions, as well as with CBIs in general, the FLC procedure is most useful in these cases. The fact that the interest of longitudinal analyses increases with the number of disaggregated cases underlines the usefulness of the proposed methodological innovation. Despite its suitability for mid-n and large-n analyses, longitudinal QCA with an FLC preserves a strong case-oriented and qualitative perspective and remains thereby loyal to QCA's original foundations.
The gendered effect of an overwork climate and high personal standards for work–home conflict during the pandemic
Authors: Žiedelis Arūnas , Lazauskaitė-Zabielskė Jurgita , Urbanavičiūtė Ieva
Published: April 2023

Although working from home and various other forms of flexible work are often presented as measures to strengthen work–life balance, research depicts a less optimistic picture. Previous research has shown that the impact of telework on work–home conflict is controversial, depending on various factors that are also frequently gender-specific. In this study, the authors evaluate and compare the effects of external expectations (i.e., an organizational overwork climate) and internal expectations (i.e., high personal standards) on changes in work–home conflict between working men and women during the COVID-19 pandemic in Lithuania. Both types of expectations were associated with difficulties reconciling work and private life. Due to their interactions with stereotypical gender roles, organizational expectations encouraging overtime work had a more pronounced effect on male employees. Results suggest that an overwork climate within organizations is a problem not only for employees’ well-being but also poses a risk to gender equality in work and private life.
Main controlling factors and oil-bearing potential characteristics of a tight sandstone reservoir: A case study of southwest Ordos Basin
Authors: Guo Feng , Peng Xiaoxia , Ma Xuqing , Wang Haonan
Published: April 2023

Clarifying the main controlling factors of reservoirs and their oil-bearing potential is vital for predicting tight sandstone reservoirs. The Chang 8 reservoir in the southwest of Ordos Basin is a typical tight sandstone reservoir and is widely distributed. Observation description and sampling analysis of cores, the grain size analysis, casting thin section, scanning electron microscope, mercury pressure, nuclear magnetic resonance, and conventional physical analysis are used to clarify the main controlling factors and oil-bearing potential characteristics of the Chang 8 reservoir in southwest Ordos Basin. The results show that delta front subfacies are mainly developed in Chang 8 member, including distributary channel, natural dike, estuary bar and distributary bay. The main rock type of reservoir is lithic feldspathic sandstone, followed by feldspathic lithic sandstone. The types of reservoir space are mainly intergranular pores and intragranular dissolved pores, with a small amount of clay-related pores and micro-fractures. The average porosity and permeability of the reservoir are 11.67% and 0.52 × 10−3μm2, respectively. The reservoirs with high oil saturation are mainly distributary channels and thicker mouth bar sand bodies. Compaction is the main factor of reservoir compaction (porosity loss rate is 55.73%), followed by cementation (porosity loss rate is 29.23%). The favorable diagenesis is the dissolution of feldspar grains and some cement. The Chang 8 tight reservoir contains various nano-scale pore-throat. For tight reservoirs with similar physical properties, the pore-throat structure controls the oil saturation of the tight reservoir. Favorable conditions for tight sandstone reservoirs oil saturation include favorable sedimentary environment (distributary channel or thick mouth bar) and suitable microscopic pore characteristics.
Association between sleep-disordered breathing and self-reported sinusitis in adults in the United States: NHANES 2005–2006
Authors: Chen Tian , Li Fen , Xi Yang , Deng Yuqin , Chen Shiming , Tao Zezhang
Published: April 2023

Objectives

The association between sleep-disordered breathing (SDB) and sinusitis has been widely studied; however, research on SDB-related sleep problems and sinusitis are limited. This study aims to determine the relationship between SDB-related sleep problems, SDB symptom score, and sinusitis.

Methods

After the screening, data were analyzed from 3414 individuals (≥20 years) from the 2005–2006 National Health and Nutrition Examination Survey questionnaire. Data on snoring, daytime sleepiness, obstructive sleep apnea (snorting, gasping, or cessation of breathing while sleeping), and sleep duration were analyzed. The SDB symptom score was determined based on a summary of the scores of the above four parameters. Pearson chi-square test and logistic regression analysis were used in statistical analyses.

Results

After adjusting for confounders, self-reported sinusitis was strongly correlated with frequent apneas (OR: 1.950; 95% CI: 1.349–2.219), excessive daytime sleepiness (OR: 1.880; 95% CI: 1.504–2.349), and frequent snoring (OR: 1.481; 95% CI: 1.097–2.000). Compared to an SDB symptom score of 0, the higher the SDB symptom score, the higher the risk of self-reported sinusitis. For the subgroup analyses, this association was significant in females and across ethnic groups.

Conclusion

In the United States, SDB is significantly associated with self-reported sinusitis in adults. In addition, our study suggests that patients with SDB should be aware of the risk of developing sinusitis.
“It Was My Story to Tell and I Wasn’t Ready to Tell It”: Stigma Management Amongst LGBTQ+ Sport Officials
Authors: Baeth Anna C. , Tingle Jacob K. , Jacobs Brittany L. , Zvosec Claire C.
Published: April 2023

The erasure of marginalized people, especially LGBTQ+ people, is commonplace in sport. As sport has become more commercialized, even at grassroots and youth levels), one group that has become even further marginalized and dehumanized are sports officials. Understanding the intersection of marginalized identities is important; as such, this study examined how homophobia and transphobia interplay with the sports officiating profession. Semistructured interviews with 16 self-identified LGBTQ+ referees revealed a series of organizational and social factors that led officials to either pass as non-LGBTQ+ or to come out as LGBTQ+, leading to the development of the LGBTQ+ Referee Identity Management Process Model. Implications for better supporting LGBTQ+ officials to promote higher levels of retention and career satisfaction are presented.
Trust and the educational gap in the demand for redistribution: Evidence from the World Values Survey and the European Value Study
Authors: Akaeda Naoki
Published: April 2023

Although previous studies have examined the influence of education on support for redistribution, studies on how this social cleavage of support for redistribution due to education varies depending on several conditions are scarce. To fill this gap, by focusing on the discussions of motivation with self-interest and with the perception of fairness, this study examines the moderation effects of social and institutional trust on the association between education and the demand for redistribution. For the analysis, the present study utilizes pooled data from multiple rounds of the World Values Survey and the European Values Study and two-way fixed-effects models. Through the international comparative analysis, this analysis finds that social trust but not institutional trust dampens the cleavage of support for redistribution due to education. These results suggest that the horizontal aspect of trust may be more influential on preferences for redistribution than the vertical aspect of trust.
Digital Marketing and Analytics Education: A Systematic Review
Authors: Ye Christine , Kim Yuna , Cho Yoon-Na
Published: April 2023

Advances in digital technologies coupled with the explosion of data are transforming the marketing education landscape at a rapid pace. Given the scale and speed of digital disruption in today’s industry, marketing academics face ongoing challenges of addressing the theory–practice gap, which will only accelerate. The purpose of the current study is to gain a better understanding of the current state of digital/social media marketing and analytics education through a review of past pedagogical research in the realm of digital/social media marketing and marketing analytics. The collected database ( N = 54) was analyzed based on their category and scope, and sub-themes within each category. Our findings indicate that while business schools have been diligent in introducing important skill sets to their curriculum, the approach has been predominately tactical, rather than driven by an overarching strategic plan. Based on the findings, we discuss the implications for marketing educators and directions for future research that can help bridge the theory–practice gap as we proceed in the future data-driven digital environments.
Pediatric optic nerve and globe measurements on magnetic resonance imaging: establishing norms for children
Authors: Raffa Anas , Raffa Lina , Kamal Yumna , Hassan Tasneem , Alaidarous Khadija , Osaylan Majed , Almarzouki Nawaf
Published: April 2023

Background

Normal optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) may be beneficial for describing optic nerve pathway abnormality reflecting increased intracranial pressure. Nonetheless, magnetic resonance imaging (MRI) measurement of the normal ONSD range and its associations with clinical factors and eyeball transverse diameter (ETD) are not well established in children.

Purpose

To establish normal OND, ONSD, ETD, and OND/ONSD and ONSD/ETD measurements in children and their associations with age and sex.

Material and Methods

We evaluated and analyzed 336 brain MRI studies of children aged 0.5 months to 18 years. We measured a total of 672 optic nerves. The OND and ONSD were measured 1 cm anterior to the optic foramina and 3 mm behind the optic disc on an axial T2 sequence.

Results

The mean OND 3 mm and 1 cm, ONSD 3 mm and 1 cm, and ETD were 0.23 ± 0.05 mm and 0.16 ± 0.04 mm, 0.53 ± 0.08 mm and 0.38 ± 0.06 mm, and 2.3 ± 0.13, respectively. Only ONSD 1 cm was independent of age ( P = 0.247). ONSD 3 mm and ETD were significantly wider in boys compared to girls and significantly influenced by age (both P < 0.001). Age at scan and ETD were significantly correlated ( P < 0.001).

Conclusion

We established MRI-based OND, ONSD, ETD, and ONSD/ETD and OND/ONSD ratio normative values in children, which can be helpful in pediatric populations with disease.
Using Crowdsourced Data to Reduce Traffic Congestion by Improving Detection of and Response to Disabled or Abandoned Vehicles on Florida Limited-Access Facilities
Authors: Sandt Adrian , McCombs John , Cornelison Erik , Al-Deek Haitham , Carrick Grady
Published: April 2023

Disabled or abandoned vehicles (DAVs) cause a significant proportion of non-recurring traffic congestion. Waze data has the potential to help traffic management center (TMC) operators detect and respond to DAVs more quickly, reducing congestion. Previous studies have examined Waze data on a small scale, but not at a statewide level. This paper analyzes over 2 years of DAV Waze data on Florida Department of Transportation (FDOT) limited-access roadways (with more than 10 million alerts) and compares them with reported DAV events (crashes and non-crash TMC reports). Over 46% of the DAV events had an associated Waze alert before the DAV event occurred, indicating significant potential for earlier detection. These Waze alerts typically happened about 16 min before the DAV event and were most common during daytime hours and in urban areas. Two roadway segments, I-4 in FDOT District 5 and State Road 91 (SR-91) in FDOT District 4, were examined in more detail. A methodology was developed to estimate the delay reduction and congestion savings achieved by the earlier detection provided by the Waze alerts for lane-blocking and shoulder-blocking disabled vehicle events. The estimated congestion savings for the second half of 2019 were $4.3 million (I-4) and $2.5 million (SR-91), with benefit-cost ratios of 61 and 27, respectively. An additional $4.3 million could potentially have been saved as a result of Waze alerts allowing responders to reach DAVs before a crash occurred. These results can help agencies understand how crowdsourced data can be effectively utilized to best improve freeway operations.
Support Needs Among Older Tenants Living in Public Housing in Sweden: Perspectives of Janitors and Maintenance Staff
Authors: Yadav Agata , Kylberg Marianne , Granbom Marianne , Malmgren Fänge Agneta , Iwarsson Susanne
Published: April 2023

Neighborhood support can improve aging in place for older adults, but research on the role of public housing staff in supporting older tenants is lacking. Twenty-nine participants (janitors, n = 11; maintenance staff, n = 18) collected data about critical situations among older tenants residing in apartments in Sweden. Modifying the Critical Incident Technique (CIT) and applying a mixed-methods design, quantitative and qualitative data were collected and analyzed with descriptive statistics and thematic analysis, integrated through narrative. We found that older tenants asked staff for help with daily tasks. The staff identified CI management dilemmas in meeting older tenants’ support needs while following the housing company’s regulations, maintaining professional responsibilities, respecting individual work attitudes and preferences, and experienced a lack of competencies in some situations. Staff members were responsive to offering support in simple, practical, and emotional situations and in addressing matters they perceived as deficits in social and health services.
Survival Benefits of Therapeutic Plasma Exchange in Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis
Authors: Lee Olive P. E. , Kanesan Nalaayeni , Leow Esther H. , Sultana Rehena , Chor Yek K. , Gan Chin S. , Lee Jan H.
Published: April 2023

Objectives

To summarize the role of therapeutic plasma exchange (TPE) in critically ill adults and children with severe sepsis.

Data collection

A systematic search was performed using the following databases: Medline, EMBASE, CINAHL, and Cochrane from January 1990 till December 2022. Comparative studies of TPE in severe sepsis were selected. Adult and pediatric data were analyzed separately.

Data synthesis

Eight randomized control trials and 6 observational studies (n = 50,142 patients) were included. Centrifugal TPE was the most common modality (209/280, 74.6% adults and 952/1026, 92.7% children). Every TPE study utilized different volume exchanges. Most TPE sessions (1173/1306, 89.8%) employed fresh frozen plasma (FFP) as replacement fluid and heparin as anticoagulant. Adults with severe sepsis supported with TPE using FFP had lower mortality (risk ratio, RR: 0.64 [95% confidence interval, CI: 0.49, 0.84]) compared to those who did not. In contrast, TPE was associated with increased mortality in septic children without thrombocytopenia-associated multiorgan failure ( RR: 2.23, 95% CI: 1.93, 2.57). There was no difference in outcomes in patients supported with centrifugal and membrane TPE. In both populations, patients supported on TPE as a continuous regime had poorer outcome.

Conclusion

Current evidence indicates that TPE is a potential adjunct therapy in adults with severe sepsis but not in children.
Juror Decision-Making in a Child Trafficking Case: The Impact of Defendant and Victim Gender, Defendant Age, and Defendant Status
Authors: Pica Emily , Hildenbrand Alexa , Fraser Laura , Pozzulo Joanna
Published: April 2023

There has been an increase in human trafficking in Canada from 2018 to 2019, which suggests a rising trend in human trafficking, and as such, the number of court cases are likely increasing. Because of this, the current study sought to examine how a defendant and victim’s gender, and defendant social status and age impacted mock jurors’ decision-making in a child trafficking case. Participants ( N = 584) read a mock trial transcript depicting a child trafficking case. They were then asked to render a verdict, answer questions relating to perceptions of the victim and defendant and rate their level of agreements on statements concerning sex and human trafficking. Although there was no effect on dichotomous verdict, mock jurors attributed higher guilt ratings to the male trafficker. Moreover, participants reported more favorable perceptions of the victim when the trafficker was female, and the victim was male compared to female. Participants also reported more favorable perceptions of the victim when the trafficker was of high social status and younger compared to older. Additionally, when mock jurors were well-informed about trafficking victim blaming did not occur. The results of the current study provide some insight into juror perceptions of child sex trafficking cases.
Not Always a “Buffer”: Self-Compassion as Moderator of the Link Between Masculinity Ideologies and Help-Seeking Intentions After Experiences of Intimate Partner Violence
Authors: Komlenac Nikola , Lamp Elisa , Maresch Franziska , Walther Andreas , Hochleitner Margarethe
Published: April 2023

Many women and men experience intimate partner violence (IPV) during their lifetime. However, only relatively few people actually seek formal help after such an experience. The current study applied the mediated-moderation model of self-compassion and stigma that has previously been used to explain men’s help-seeking behavior for depressive symptoms. The current study analyzed whether conformity to masculinity ideologies (CMI), self-stigma, and self-compassion were related to women’s and men’s intention to seek formal help after IPV experiences. A cross-sectional online questionnaire study was conducted with 491 German-speaking participants (65.8% women/34.2% men; age: M = 36.1 years; SD = 14.2). Participants read three vignettes about experienced IPV and then indicated how likely they would be to seek medical or psychological help if they were in the main character’s situation. Additionally, the Conformity to Masculine Norms Inventory, Self-Stigma of Seeking Help Scale, and Self-Compassion Scale were used. Separate manifest path models for women and men revealed that strong CMI was linked to strong self-stigma in women and men. In turn, strong self-stigma was linked to weak intentions to seek formal help after IPV experiences. In men, strong self-compassion weakened (i.e., “buffered”) the link between CMI and self-stigma. However, direct associations between strong CMI and weak intentions to seek formal help remained, especially for those participants with strong self-compassion. The current study adds to the existing literature on associations between CMI, self-compassion, and self-stigma by showing that those links are also relevant in women. However, self-compassion might not always act as a “buffer” and mediators that explain links between strong CMI and weak intentions to seek formal help in people with strong self-compassion need to be found in future studies.
Factors Influencing College Students’ Perceptions of Sexual Violence on Campus: An Exploratory Study
Authors: Chiffriller Sheila H. , Doshi Poonam V. , Geiling Elizabeth C. , D’Urso Michaela
Published: April 2023

The aim of this study was to examine how participant, aggressor, and survivor variables as well as form of aggression influence college students’ perception of sexual aggression in terms of seriousness, responsibility, and appropriate reporting behaviors, actions to protect the survivor and enforce consequences for the aggressor. Previous research indicates that the majority of reported sexual assault cases on college campuses involved alcohol use by either the victim, the perpetrator, or in some cases, both. In this study, four different scenarios were created, consisting of four different forms of aggression wherein both aggressor and survivor were consuming alcohol. These four scenarios were then combined with images, in which the race of the aggressor and race of the target were varied to create 16 different scenarios. The results indicated that the form of aggression and the race of the victim and aggressor did not influence students’ perceptions of the seriousness of the aggression. However, there were significant differences into whom students recommended reporting, strategies to protect the survivor and consequences for the aggressor. Findings indicated both gender differences and racial biases in terms of recommended consequences for the aggressor. Implications for program development and improvement as well as future research recommendations are discussed.
How People With Intellectual or Development Disabilities Cope With Verbal Violence
Authors: Karni-Vizer Nirit , Neuman Ran
Published: April 2023

Violence against people is a widespread phenomenon and violence against people with disabilities even more common. Studies have examined different types of violence toward people with disabilities, but there has been almost no research to date on verbal violence involving people with intellectual or development disabilities (IDD). The present research focused on this subject. A qualitative study was conducted using an intervention program. The research questions were (a) what can help people with IDD expand their understanding of verbal violence and differentiate different situations of verbal violence and (b) what can help people with IDD expand their means for handling verbal violence of their own and that directed toward them? The sample included 64 people (45 males, 19 females; ages 22–75) with mild IDD, who were divided into four groups of 16 participants each in the intervention program. The findings indicate that the participants’ conceptualization of verbal violence improved after the intervention program. Three main themes were identified: (a) differentiation between good and bad; (b) choosing how to handle verbal violence; and (c) helping others cope with verbal violence. Consistent with the humanistic perspective, the findings show that people with IDD can learn to handle verbal violence toward them in a way that promotes their understanding, enables them to choose their reactions, and affects those around them, as well as strengthening their self-efficacy. The research contributes to the sparse knowledge regarding verbal violence, especially against people with IDD, and offers ways of intervening to help them handle verbal violence.