bluuebunny/crossref_metadata_2025 huggingface dataset:
Ambivalence juridique : les regards de la France sur la relation archéologie et monuments historiques (1886-2004)
Authors: Guilhot Jean-Olivier
Published: June 2022

Au XIXe siècle et au XXe siècle, lorsque la France légifère sur l’archéologie et les monuments historiques, elle adopte un parti différent selon qu’elle traite de ses protectorats (Tunisie, Maroc) et de ses mandats (Liban, Syrie) ou selon qu’elle traite du territoire national.La place réservée à l’archéologie dans le dahir marocain relatif à la conservation des Monuments Historiques, des Inscriptions et des objets d'art et d'antiquité de l'Empire Chérifien promulgué le 13 février 1914, soit moins de deux mois après la Loi française du 31 décembre 1913 sur les monuments historiques atteste que l’attention portée par la France au patrimoine ne sera désormais pas la même sur le territoire français et sur les territoires qu’elle contrôle. La fracture entre un patrimoine codifié comme un tout cohérent hors de France et un patrimoine réduit aux seuls monuments historiques en France semble alors consacrée. La Loi du 27 du septembre 1941 portant réglementation des fouilles archéologiques ne fera que confirmer qu’il s’agit de domaines différents régis par des lois spécifiques et bientôt gérés par deux services du ministère de la culture qui pendant longtemps s’ignoreront. On comprend dès lors la difficulté qu’il y eut à faire émerger en France une archéologie du bâti et les désaccords qui demeurent encore aujourd’hui au sein du ministère de la culture pour arrêter une position sur la prescription, l’exécution, le contrôle et le financement de l’archéologie dans les monuments historiques.
Healthcare Accreditation as a Tool for Financial and Risk Management Analysis
Authors: Ziemba Elizabeth
Published: June 2022

The risk management landscape for healthcare providers is growing more complex, presenting hospitals and clinics with regulatory compliance challenges. Accreditation plays an important role in providing risk management best practices, offering expertise to healthcare providers to navigate risk management demands. The current business climate makes it difficult for financial organizations to assess risk. Opportunities are lost to leverage the accreditation process including the assessment report. Healthcare providers can access accreditation standards and expertise to improve overall performance. Successfully accredited hospitals and clinics may utilize accreditation reports to negotiate more favorable financial terms and conditions. Financial organizations can use accreditation reports to help evaluate providers' operational and financial risks. Healthcare providers and financial organizations are failing to maximize the benefits of accreditation including accessing risk-related information in the assessment report.
Artificial Intelligence Machines in Medicine and Healthcare Management
Authors: Mozayeni B. Robert
Published: June 2022

In medicine, as in many aspects of our lives, we are experiencing the implementation of software tools described as artificial ‘intelligence' (AI) or, more precisely, machine learning (ML). These are systems built on a body of mathematics combining Bayesian probability modeling, rules, and neural networks (NN). This transformational technology is a cause for much optimism and concern. The change enabled by any new technology is naturally followed by a gradual appreciation of the impact, as optimism is gradually tempered by real experiences, often as we revise and refine our opinions in a dialectic manner. It takes time to understand the capabilities of these AI and ML tools before we can feel safe and comfortable working with them in critical tasks. These issues are discussed from various perspectives with implications for the future of how we consider evidence in medical decision-making.
International Accreditation Standards and the Benefits to Hospitals Attracting Medical Tourists
Authors: Vequist IV David G. , Geva Ilan , Poe April
Published: June 2022

There are several studies showing international hospital accreditation does have some impact on clinical standards and even bed occupancy rates. However, little is known about the impact on attracting more international medical tourists to hospitals that have received this distinction. It was expected, prior to the study, that participating in international accreditation might increase operational expenses and greater amounts of international patients would also boost patient volumes and profitability. However, this research found that the investment in accreditation led to insignificant changes (pre-accreditation versus post-accreditation) in operating profit margins (OPM), net profit margins (NPM), and the debt-to-equity (D/E) ratio. This suggests that international hospital accreditation has little impact on the financial aspects of the hospital's operations. It appears to be more of a signaling strategy than a recipe for growth. However, there may be some other tangible benefits of international accreditation (e.g., better medical/clinical outcomes).
Healthcare Workers' Beliefs Regarding PPE and Calculated Risk for Infection During the COVID-19 Pandemic
Authors: Morales Katie , Monk Sandra E.
Published: June 2022

The coronavirus (COVID-19) pandemic presents unprecedented challenges to the availability and use of personal protective equipment (PPE). Healthcare workers' adherence to PPE use has been suboptimal placing patients, workers, and the public at risk. The purpose of this study was to identify healthcare workers' health beliefs regarding PPE and their risk for infection during the COVID-19 pandemic. This article describes the quantitative component of a mixed methods study. The quantitative phase was descriptive and nonexperimental. A link to an online survey was distributed through social media outlets and professional nursing organizations to record healthcare workers' perceived health beliefs regarding PPE and their risk for infection during the COVID-19 pandemic. Factors that affected healthcare workers' health beliefs regarding PPE during the COVID-19 pandemic included COVID vaccination status, adequate PPE resources in their healthcare setting, and if they provided direct care.
Full-Scale Reynolds Number Testing of Rotor Hub Drag and Wake Turbulence
Authors: Reich David B , Krane Michael H , Willits Steven M , Schmitz Sven
Published: June 2022

A 1:4.25-scale model of a generic helicopter rotor hub was tested at Reynolds numbers ranging from 1. 75× 106 to 7×106 at advance ratio of 0.2 in The Pennsylvania State University Applied Research Laboratory Garfield Thomas 48-inch
diameter water tunnel. Measurements including drag and wake characteristics were performed up to full-scale Reynolds number with respect to an industry-representative helicopter rotor hub. In particular, the variation of drag and flow field with Reynolds number was characterized. Load measurements
were conducted using an improved load cell design, with greater accuracy than in previous experiments. Wake velocity was measured using laser Doppler velocimetry at two downstream planes, yielding velocity statistics to the second order. Improved load measurement accuracy and wake velocity
spatial resolution, at full-scale Reynolds number, provide a unique dataset for computational fluid dynamics validation as part of the Penn State Rotor Hub Flow Prediction Workshops and physical insight into rotor hub flows.
Isolated Duodenal Duplication Cyst in a Neonate
Authors: Hakda Riyazhussein Yakoob , Makwana Deepen V. , Shukla Ramendra , Parikh Urvish , Chandna Sudhir B.
Published: June 2022

Duodenal duplication cysts are a rare subtype of alimentary tract duplications cysts, consisting of 7% of all the duplications. We report a rare case of neonatal duodenal duplication cyst presenting as a palpable abdominal mass and features of gastric outlet obstruction. A 27-day-old male child presented with complaints of icterus, non-bilious vomiting after every feed and right-sided abdominal lump for the last 15 days. A computed tomography scan of the abdomen revealed well-defined peripherally enhancing cystic lesion noted in the subhepatic region extending up to the right lumbar region. On surgical exploration, a cystic mass was found attached to the pyloric part of the stomach along the mesenteric border of the first, second and third part of the duodenum, which was marsupialised, and no communication was found with the duodenum. On histopathological analysis, a duodenal duplication cyst was diagnosed without any heterotopic mucosa. The literature was reviewed and the approach to duodenal duplication cyst in neonates is discussed.
Current telepsychiatry practice in India - An online survey of psychiatrists
Authors: Basavarajappa Chethan , Grover Sandeep , Dalal Pronob K , Avasthi Ajit , Kumar Channaveerachari Naveen , Manjunatha Narayana , Mehra Aseem , Saha Gautam , Sahoo Swapnajeet , Singh Om Prakash , Tripathi Adarsh , Gangadhar Bangalore N , Math Suresh Bada
Published: June 2022

Context:

Telemedicine Practice Guidelines and Telepsychiatry Operational Guidelines released in 2020 have provided legal backing for telepsychiatry practice.

Aims:

To understand the current telepsychiatry practices in India.

Settings and Design:

An online survey was conducted after ethics approval by the IPS Ethics Review Board. All psychiatrists, who are members of the Indian Psychiatric Society and whose email address was available with the society, were sent the survey link by email.

Methods and Material:

Information about existing telepsychiatry consultation practices in India was collected between June and July 2020.

Statistical Analysis Used:

Frequency, percentages, mean, and standard deviation were calculated.

Results:

340 responses were analyzed. Nearly three-fourths of the responders used smartphones (n = 260, 76.47%) for audio consultations (n = 196, 57.65%). Among those who were using a dedicated software (n = 36), one-third used the Zoom software (n = 12, 33.33%). Nearly three-fourths (n = 218, 73.4%) provided prescriptions with their registration number on a letterhead in the form of an email or text message. Two-thirds of the responders (n = 228, 67.06%) felt that in-person consultation is better. Many preferred a combination of voice, video, and text including emails (n = 134, 42.01%).

Conclusions:

This online survey showed that the use of technology has caught up with the practicing psychiatrists. Many are practicing telepsychiatry either formally or informally in India and are comfortable and satisfied with the telepractice.
Role of calcium metabolism in ADHD: The relationship between parathyroid hormone and ADHD symptom severity
Authors: Altun Varmiş Dilek , Yapça Kaypakli Gamze , Yolga Tahiroğlu Ayşegül , Avci Ayse , Gül Çelik Gonca , Metin Özge , Matyar Selcuk , Öztürk Özlem Görüroğlu
Published: June 2022

Background:

Vitamin D has been found to be associated with the pathogenesis of attention deficit hyperactivity disorder (ADHD). However, the potential role of parathyroid hormone (PTH) is still unclear.

Aim:

We aimed to investigate the association between calcium metabolism and ADHD symptomatology.

Methods:

We included 106 participants aged between 7 and 13 years old (51 ADHD patients, mean age: 9.54 ± 1.77, 55 healthy controls mean age: 9.97 ± 0.94) to this study. K-SADS-PL and Conners’ Parent/Teacher Rating Scales, Stroop Test were performed. Blood samples to measure serum levels of Vitamin D, PTH, calcium (Ca), magnesium (Mg), phosphorus (P), and alkaline phosphatase (ALP) were collected in the spring (March–April–May) to prevent seasonal variability.

Results:

PTH, P, and ALP values were significantly lower and Vitamin D, Ca, and Mg values were significantly higher in the ADHD group (P < 0.05, for all). Both groups had Vitamin D deficiency. Control group has lower Vitamin D levels than the ADHD group (respectively; 17.66 ± 9.07, 21.99 ± 10.99, P < 0.05). There was a negative correlation between PTH and CTRS hyperactivity, CGI-RI and CGI-EL sub-scores, CGI-Total, DSM-IV-Inattention, DSM-IV Hyperactivity/Impulsivity, DSM-IV-Total scores (P < 0.05, for all).

Conclusions:

We found lower PTH levels in ADHD patients and a strong and negative correlation between PTH and symptom severity. Future studies are needed to clarify if these findings are due to the key role of PTH in ADHD pathology or PTH’s function in activating vitamin D.
Free legal aid in hospitals for persons with mental illness: Is it helpful? An Indian prospective study
Authors: Kadiveti Sriharsha , Vajawat Bhavika , Kumar Channaveerachari Naveen , Hegde Prakyath R , Moirangthem Sydney , Math Suresh Bada
Published: June 2022

Background:

Legislative backing exists to set up free legal aid clinics in psychiatric hospitals to provide legal assistance to their patients.

Aims:

This study aimed to assess the utility of a free legal aid clinic running inside a mental health establishment.

Methods:

In this prospective study, 71 subjects (chosen via convenience sampling) were recruited. Assessments were carried out at baseline and two months after intake. Legal needs and the legal outcomes were assessed.

Results:

Most of the legal issues were either family-related (50.7%) or civil issues (28.2%). A majority of patients (64.4%) had implemented the advice given at the clinic. Those who had implemented the advice had a better legal outcome, defined as either resolution of the legal issue or that the legal issue was in an active proceeding compared to those who had not implemented the advice (P = 0.007).

Conclusion:

The provision of free legal aid services in mental health establishments would benefit patients.
Epidemiology, Pathogenesis, Clinical Presentation, and Diagnostic Approach
Authors: Patel Pratik , Chaudhary Kshitij , Dalvie Samir
Published: June 2022

Spinal metastatis is a diagnostic and treatment challenge for the spine surgeon and must be addressed through multidisciplinary, multimodal, and individualized management. The presence of tumor cells in bone metastases results in homeostatic disruption between bone formation and remodeling and leads to osteolytic, osteoblastic, or mixed bone lesions. Spinal metastases are a significant cause for morbidity characterized by severe pain, impaired mobility, pathological fractures, spinal instability, and neurological involvement. Radiographs, magnetic resonance imaging, computed tomography, and positron emission tomography are widely used for the detection and staging of the disease. Histopathological examination is crucial to establish an oncological diagnosis. Our review focuses on epidemiology, pathogenesis, clinical presentation, and diagnosis of spinal metastasis.
Employing comics for strengthening the delivery of medical education and patient care
Authors: Shrivastava Saurabh RamBihariLal , Shrivastava Prateek Saurabh
Published: June 2022

The medical knowledge is extremely vast and continues to advance with each day making it extremely challenging for medical students. One of the innovative teaching-learning methods has been the use of comics in the field of delivering medical education and for improving patient care. The utility of comics in the delivery of medical education can be explained in different ways, namely mediation of varied emotional states upon errors made while diagnosis, highlighting illustrations about the good and bad practice of medicine, etc. Like any intervention, even the use of comics in medical education and clinical practice has its own challenges. To conclude, the integration of comics in medical education and patient care is an innovative approach to strengthen the overall process of curriculum delivery. The need of the hour is to understand its scope and then use in relevant settings to make it more effective and beneficial to different stakeholders.
Management of wrist electrical burns with utilisation of recent modalities for better functional outcome
Authors: Korambayil Pradeoth Mukundan , Thattaruparambil Vinayak Prakash , Dilliraj Vinoth Kumar , Varkey Prashanth Ambookan , Ravindran K. Rameela
Published: June 2022

Background:

The aim is to study the sequence of events contributing the survival of wrist electrical burns and reconstructive options for salvage of soft tissue of electrical burns of wrist.

Methods:

Data of patients with high tension electrical burns involving the wrist admitted in our hospital from January 2018 to December 2020. There were 17 patients with electrical burns with wrist injury. Patients from age 18 to 65 years were included in the study. Patients were subjected to bio immunoassay, infrared thermography, indocyanine fluorescent scan, hyperbaric oxygen therapy and reconstructive procedures.

Results:

Among 17 patients, 16 were male. Their age ranged from 20 to 61 years. The injury resulted from 11 kv voltage line most often and the patients were admitted within a day of injury. All patients were subjected to multiple staged procedures of debridement and reconstruction. 7 patients were subjected to amputation of the limb, 5 patients subjected to reconstruction in terms of abdominal flap and 4 with groin flap and one perforator plus flap was used to cover the wrist defect.

Conclusions:

Wrist electrical burns due to its crucial location, requires knowledge on disease process, if ignored will directly lead to significant morbidity. Utilisation of newer modalities will help in timely intervention and salvage of the limb.
Necrotising fasciitis following a monkey bite
Authors: Pandiaraja Jayabal
Published: June 2022

Necrotising fasciitis (NF) is rapidly spreading bacterial infection of a facial plane. It has a higher mortality rate in patients with diabetes and immunocompromised state. The initial presentation mimics cellulitis and most of the cases are misdiagnosed. Delayed diagnosis and treatment increase mortality by nearly 100%. Our patient had developed NF with septic shock following a monkey bite. The patient underwent prompt fasciotomy along with extensive wound debridement. Later patient underwent secondary suturing with a skin graft for wound cover. NF following money bite is not reported in the literature till now. Hence, early diagnosis and prompt surgical debridement in monkey bites will reduce the incidence of mortality due to NF.
Impact of haemodialysis on cardio-metabolic burden in chronic kidney disease patients - A prospective cohort study
Authors: Okorie Kalu Kalu , Onwukwe Chikezie Hart , Chikezie Nkiru Ifeoma , Kalu Offia , Osuji Charles Ukachukwu
Published: June 2022

Background:

Maintenance haemodialysis (MHD) is the major form of renal replacement therapy in Nigeria, and may have a significant impact on cardiovascular (CV) and metabolic burden in chronic kidney disease (CKD) patients.

Methods:

This is a prospective cohort study involving 40 CKD dialysis-naïve end-stage renal disease patients who were assessed at first contact before commencing dialysis and assessments repeated 3 months later while on MHD. Clinical, echocardiographic and biochemical indices were assessed on both occasions. We studied the impact of MHD on CV risk factors such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF), high calcium-phosphate product, hypoalbuminaemia, anaemia and dyslipidaemia.

Results:

The mean serum calcium-phosphate product, plasma total cholesterol, triglycerides and low-density lipoprotein cholesterol were significantly higher at baseline than at three months; while the mean haemoglobin, serum albumin and plasma high-density lipoprotein were significantly lower at baseline than at 3 months (P < 0.01). There was a significant difference in echocardiographic indices at baseline and at 3 months in CKD patients on MHD. Left ventricular mass and left ventricular mass index were significantly higher at baseline than at 3 months (P < 0.01); while LVEF was significantly lower at baseline than at 3 months (P < 0.01).

Conclusions:

Our study showed statistically significant improvements in CV risk factors among CKD patients after 3 months on maintenance haemodialysis. Early and effective maintenance haemodialysis reduce CV risk factors in Nigerian CKD patients.
Tooth Loss and Its Risk Factors Among the Young Adults in the Kamrup (Metro) District of Assam
Authors: Barman Jogeswar , Kalita Chandana , Baruah Rupali , Choudhury Kalyani
Published: June 2022

Background:

Epidemiological studies on tooth loss, particularly in young adults (20–40 years), are very sparse, and it was probably not done in Assam and the whole of the northeast region of India.

Aim:

The aim of this study was to determine the role of the oral health determinants and analyze their potential risk on tooth mortality among the young adults of the rural and urban areas of Kamrup (Metro) district of Assam.

Materials and Methodology:

A total of 1540 young adults (20–40 years), 770 each from the urban and rural areas of the Kamrup (Metro) district, were selected using multistage cluster sampling. Oral health assessment was done by asking individual questionnaires and intraoral examinations. Collected data were statistically analyzed using Mann–Whitney U-test, Kruskal–Wallis test, and Pearson's Chi-square test at 0.05 significance level.

Results:

Overall 30.6% of the young adults demonstrated one or more tooth loss with no significant difference between rural (29.70%) and urban areas (31.40%). Tooth decay is the prime cause of tooth loss (23.7%), followed by tooth mobility (4.5%) and trauma (0.9%). The potential risk of tooth loss can significantly be influenced by education, occupation, consumption of sweet food, water sources, oral hygiene practices, smoking and chewing of different types of smokeless tobacco, paan-betel nuts, paan-masalas, and consumption of alcohol (P < 0.001).

Conclusion:

Tooth loss is a major oral health problem affecting >30% of the young adults. The potential risk of tooth loss due to major oral diseases can be influenced by education, occupation, sweet food, water sources, oral hygiene practices, bad oral habits, and alcohol consumption.
Effect of Physical Activity on Oral Health
Authors: Medapati Anuhya Reddy , Pachava Srinivas
Published: June 2022

Background:

Although there is remarkable evidence in the literature that there is an association between physical activity and general health, the possible influence of physical activity on oral health outcomes has not been well documented. The aim of this study is to assess the effects of physical activity on oral health.

Methodology:

An aggregate of 112 studies has been retrieved from PubMed, Cochrane Library, and Turning Research Into Practice databases from 2001 to 2020, of which 14 observational studies have been integrated into this systematic review.

Results:

Among the included studies, four studies have reported an association between periodontal disease and regular physical activity. Four studies reported an association between oral health behavior and physical activity. Two studies found an association between physical activity and dental caries.

Conclusion:

The findings from the present systematic review revealed an association between oral health, oral health behaviors, and individuals practicing physical activity. It was observed that there were reduced inflammatory biomarkers in physically active individuals, which in turn was related to improved periodontal health. As this review only looked at studies that were based on observations, more studies were suggested to see if there was a possible cause-and-effect relationship between each condition.
Cost Calculation of a Tertiary Care Referral Dental Center Using Activity-Based Costing Method
Authors: Sunil Vadde Venkata Naga , Mrunalini Koneru , Prathima Vedati
Published: June 2022

Background:

Economic evaluations in dentistry provide policymakers with information to facilitate efficient resource allocation. Dentistry involves multiple activities for one treatment outcome. This original research aims to calculate direct treatment and indirect costs for dental services provided at tertiary care referral dental center.

Materials and Methods:

The present original study reporting is done based on using the Consolidated Health Economic Evaluation Reporting Standards statement in dentistry, the basic dental services provided are divided into direct (revenue-generating) and indirect cost centers (nonrevenue generating) using activity-based costing (ABC) method. The total cost generated is calculated by aggregating the sum of direct and indirect cost incurred and unit cost is calculated by dividing total cost obtained by the number of units. Data are analyzed using Microsoft Excel worksheet.

Results:

Cost calculated using ABC method differed significantly from the tariff method. The major cost components varied are human resources (848,000 INR), capital costs (3,008,500 INR), and material costs (200,000 INR).

Conclusion:

At a tertiary care dental hospital level, we must provide patient's perspective care that is respectful of and responsive to individual patient preferences, needs, and values and ensuring that patient values guide all clinical decisions. By taking correct economic managerial decisions using ABC and budgeting the resources to dental services, the community can approach with true patient costs at an acceptable level of quality and at the least possible cost.
Awareness Regarding COVID-19 Preparedness Among Dentists
Authors: Jain Swati , Mohanty Vikrant , Gangil Neha , Arora Shipra , Bajaj Annudeep
Published: June 2022

Background:

Novel coronavirus pandemic has emerged as a grave global health crisis. The pandemic curve is still on the rise. Dental professionals face unique challenges and work pressure due to the fear of the spread of disease while coming in close contact with the potential carriers.

Aim:

The aim is to assess the knowledge and preparedness level toward novel coronavirus diseases among the dental professionals of India.

Methodology:

Online survey was carried out from May 2020 to June 2020 on dental health care professionals through snowball sampling. A 24-item structured closed-ended online questionnaire was used.

Statistical Analysis Used:

Frequency distribution and proportions of the responses were analyzed using the SPSS version 21.

Results:

A total of 154 dental professionals participated in the study. Majority of the respondents (72.72%) were aware about the correct genomic structure of the virus and aptly identified the early neurological symptom of novel coronavirus disease. 85.71% of the respondents were appropriately informed about the infection control protocol to be followed. However, regarding the protection level to be used while dealing COVID patients, only 24.03% of respondents correctly identified it as Level III. Regarding the amendments required in dental practice and level of preparedness, only 50% of the dental health-care workers were aware of the sequence of donning of personal protective equipment.

Conclusions:

In the present study, dentists were found to have good knowledge toward novel coronavirus disease with optimum preparedness level for dental practice modification. Dental fraternity is further advised to follow the standard guidelines overcoming this pandemic.
Faculty-or senior resident-led SNAPPS for postgraduate teaching in pediatrics
Authors: Dabas A , Mishra D , Swarnim  , Saxena R
Published: June 2022

This was an educational intervention on postgraduates using SNAPPS (Summarize narrow, analyze, probe, plan, self-directed learning) showing comparable median (interquartile range) satisfaction scores with faculty or senior residents as 4 (3,5) and 4 (4, 4.25); respectively, P = 0.79. Further training of senior residents in medical education will enable them to participate efficiently and actively in postgraduate teaching.
Rhizoma Drynariae Improves Endometrial Receptivity in a Mus Model of Dysfunctional Embryo Implantation
Authors: Shi Yue , Liu Yan-Feng , Wang Jia-Mei , Jiang Jing , He Bo-Lin , Mu Guo-Hua , Liu Fang , Li Ya-Hui , Qiao Ting , Lu Jing
Published: June 2022

Background:

Rhizoma drynariae is a traditional Chinese medicine used in orthopedics and traumatology, but its effect on endometrial receptivity remains unknown.

Aims and Objectives:

To observe effect of Rhizoma drynariae and its main components on endometrial receptivity in a mus model of dysfunctional embryo implantation.

Materials and Methods:

Mus models were established by the GnRHa+HMG+HCG method. Normal mus receiving saline were used as controls and the remaining six groups were: model receiving saline, progynova, aspirin, Rhizoma drynariae, osteopractic total flavone, and naringin. Pinopodes in uterine endometrium were examined by scanning electron microscopy. Stem cell factor (SCF) mRNA expressions was determined by real-time RT-PCR, and estrogen receptor α (ERα), progesterone receptor (PR) by immunohistochemistry.

Results:

In the model group, surface morphology of endometrium was heterogeneous, without obvious pinopodes. In the Rhizoma drynaria and progynova groups, pinopodes were abundant. Compared with the blank group, model group had lower levels of SCF (-47%), ERα (-63%) and PR (-50%) (all P<0.05). In comparison, Rhizoma drynariae group had higher levels of SCF (+73%), ERα (+118%) and PR (+101%) (all P<0.01). The individual main components of Rhizoma drynariae had variable efficacy.

Conclusion:

Rhizoma drynariae could improve endometrial receptivity of mouse models of dysfunctional embryo implantation as shown by increased numbers of pinopodes and higher levers of SCF, ERα, PR compared with the model group.
Smart Advertising: Innovación y disrupción tecnológica asociadas a la IA en el ecosistema publicitario
Authors: Martínez Martínez Inmaculada José , Aguado Juan Miguel , Sánchez Cobarro Paloma del Henar
Published: June 2022

Introducción: El impacto de la inteligencia artificial (IA) en las industrias del contenido y la comunicación es objeto de atención creciente en los últimos años. La literatura y las investigaciones en este sentido han tendido a centrar el foco en los sectores vinculados a la producción o distribución de distintas formas de contenido. La publicidad, sin embargo, ha permanecido en un discreto segundo plano. Este artículo pretende sacar de ese segundo plano al estudio de la IA en publicidad, identificar la orientación y alcance de las investigaciones recientes sobre el tema y ofrecer un mapa de las líneas de investigación en desarrollo, acotándola como un vector clave de innovación de base tecnológica en el nuevo ecosistema mediático. Metodología: Para ello se ha desarrollado una revisión sistemática exploratoria cualitativa (qualitative scoping review) de la literatura de investigación sobre IA y publicidad, completada por la aportación de informes profesionales del sector. Resultados y discusión: La literatura existente apunta a la eficacia en el procesamiento de grandes conjuntos de datos desestructurados, el análisis predictivo / prescriptivo, el reconocimiento del lenguaje natural y de las imágenes y la capacidad de automatización de tareas como principales vectores de innovación de la IA. El impacto disruptivo de la IA afecta a todas las fases del proceso publicitario: investigación y análisis de mercados, creatividad, planificación y compra de medios y evaluación de la eficacia. Conclusiones: Las investigaciones tienden a perpetuar la estructura tradicional del proceso publicitario y obvian la dimensión ecosistémica de la innovación, que transforma a los actores y sus relaciones.
Impact of diabetes-related knowledge and medication adherence on quality of life among type 2 diabetes patients in a tertiary health facility in Multan, Pakistan
Authors: Ramzan Basit , Hassali Azmi , Hashmi Furqan , Saleem Fahad , Gardezi Shahnawaz , Hussain Iltaf , Butt Muhammad Daoud , Rasool Muhammad Fawad
Published: June 2022

Purpose: To assess the impact of drug adherence and diabetes-related knowledge on the quality of life (QoL) of type 2 diabetes patients in a hospital in Pakistan.Methods: A cross-sectional study was conducted in City Hospital, Multan, Pakistan between March and September 2020. A total of 151 patients diagnosed with type 2 diabetes mellitus (T2DM) were recruited. Medication adherence, diabetes-related knowledge, and QoL were assessed by Drug attitude inventory-10 (DAI-10), the Michigan Diabetes Knowledge Test (MDKT), and EQ-5D-3L tools, respectively. The association between sociodemographic data and study variables was assessed by independent t-test and one-way ANOVA.Results: Among the 151 patients, 53 % were males. The mean MDKT score was 0.33 ± 0.18, indicating poor knowledge of diabetes. An overall moderate level of adherence was observed among the participants (mean adherence score, 6.14 ± 1.39). Mean QoL score was 1.31 ± 0.28, and the Visual Analog Scale score (VAS) was 59.6 ± 12.21, indicating a good to moderate QoL among the study participants. Study participants with a longer duration of diabetes and poor adherence to their medications showed poor QoL (p = 0.01, p = 0.004 respectively).Conclusion: Overall, the patients reported poor knowledge, moderate adherence, and good to moderate QoL. Moreover, patients with poor adherence to medication, longer duration of diabetes, and poorly controlled HbA1c showed poor QoL.
Amygdalin suppresses the proliferation, migration and EMT of gastric cancer cells by inhibiting TGF-β/Smad signal pathway
Authors: Xu Junwei , Qin Ning , Jiang Wenbo , Chen Tao
Published: June 2022

Purpose: To investigate the effects of amygdalin on the proliferation, motility and epithelial mesenchymal transformation (EMT) of gastric cancer cells and to elucidate the operating mechanisms of action.Methods: Gastric cancer AGS cells were treated with amygdalin (2.5, 5 and 10 mg/L). MTT and colony formation assays were used to investigate the effect of amygdalin on gastric cancer cell proliferation, while wound healing and Transwell assays were also carried out to determine its effect on the motility of gastric cancer cells. Immunoblot assays were used to investigate the effects of amygdalin on epithelial mesenchymal transformation (EMT) process and TGF-β/Smad pathway in gastric cancer cells.Results: Treatment with amygdalin suppressed the proliferation of gastric cancer AGS cells (p < 0.05). Amygdalin suppressed the migration and invasion of AGS cells in vitro (p < 0.05). Additionally, amygdalin suppressed epithelial mesenchymal transformation (EMT) in AGS cells, and suppressed TGF-β/Smad pathway (p < 0.05), thereby suppressing growth, motility, and EMT in AGS cells.Conclusion: Amygdalin may be useful for the treatment of gastric cancer; however, further studies are required ascertain this.
Comparison of COD and TOC in influents and effluents of six industrial wastewater treatment plants in Korea
Authors: Park Soohyung , Lee Chaeyoung , Kim Keug Tae , Kim Hyun Woo , Lee Wontae
Published: June 2022

Objectives : This study compared the CODMn and TOC concentrations of the influent and effluent from six industrial wastewater treatment plants (WWTPs) and the wastewater from manufacturing facilities in the industrial complexes, and to understand the correlation between the two indicators.Methods : The sampling campaigns were performed four times at each WWTP for both influent and effluent. Water quality surveys were also conducted to assess the characteristics of organic matter in the wastewater from the manufacturing facilities. A total of 272 facilities including manufacturing, non-manufacturing, and miscellaneous manufacturing units were surveyed. Results and Discussion : The CODMn/TOC ratios of the influent and the effluent of the WWTPs ranged from 0.78 to 1.79 (average 1.19) and 0.94 to 1.58 (average 1.20), respectively. The ratio of CODMn/TOC ratio in the wastewater from the manufacturing facilities was 1.06~1.22 (average 1.12). Industries with high R2 values for the CODMn/TOC ratios included rubber and plastics manufacturing (CODMn/TOC = 1.17), nonferrous metals manufacturing (CODMn/TOC = 0.94), medical materials and pharmaceutical manufacturing (CODMn/TOC = 0.98), and chemicals manufacturing (CODMn/TOC = 1.27).Conclusion : CODMn/TOC ratios of the influent and effluent of the six plants and the wastewater from manufacturing facilities varied in different ranges for each WWTP, with an average value of 1.12. The results of this study can be used as basic information to manage the effluent water quality of the WWTPs.
Beyond Net Zero: How to Mobilize Passive Investing Towards Paris Alignment With a Focus on the United States
Authors: Zhou Lihuan , Wu Yili , Lee Anderson , Pinchot Ariel
Published: June 2022

This paper provides a comprehensive and evolving framework for Paris-aligned passive investing, developed through expert consultations, using existing Paris Agreement-related frameworks, taxonomies, data sources, and principles. The framework is then used to analyze existing popular US sustainable funds and EU Paris-Aligned Benchmark funds to see how well they fulfill the criteria, revealing considerable deficiencies in portfolio construction across the board.
Acetylcholinesterase histochemistry: A very useful technique in the diagnosis of Hirschsprung’s disease
Authors: Tripathi Brijesh K , Ghosh Amrita , Pandey Vaibhav , Gangopadhyay Ajay N , Chawdhary Sarita , Sharma Shiv P
Published: June 2022

Hirschsprung’s disease (HD) is a common congenital paediatric disorder. The gold standard for its diagnosis is the demonstration of the absence of ganglion cells on H&E stained sections from a spastic segment of the bowel, still at times; conclusive diagnosis of HD is difficult. This study was done to assess the accuracy of rapid Hematoxylin & Eosin (H&E) staining and AChE histochemistry in combination for the diagnosis of HD, especially in frozen section specimens. Samples from 36 clinically suspected HD cases were evaluated for the presence or absence of ganglion cells on H&E staining on both fresh-frozen and paraffin-embedded sections, whereas AChE staining was done on frozen sections only. Of the 36 cases of frozen section specimens from the spastic region of the colon, GCs were absent in 28 cases on H&E staining while positive staining patterns on AChE histochemistry were observed in 29 cases. Formalin-fixed paraffin-embedded sections showed the absence of GC on H&E staining in 28 cases. The sensitivity and specificity of frozen sections with rapid H&E were 77.78% and 81.82% while the sensitivity and specificity of AChE histochemistry were 80.56% and 81.82% respectively in the diagnosis of HD. Application of AChE histochemistry as an ancillary technique on frozen sections specimens of HD in combination with rapid H&E staining is very useful for definitive diagnosis of HD.
The previous concept of the cosmopolitan pest ant Tapinoma melanocephalum (Fabricius, 1793) includes two species (Hymenoptera: Formicidae: Tapinoma)
Authors: Seifert Bernhard
Published: June 2022

Tapinoma melanocephalum (Fabricius, 1793), known under the vernacular name Ghost Ant and being a widely distributed cosmopolitan tramp species with significant pest status, has been considered long-since to represent a single species. Yet, investigation of 83 worker samples from the whole globe provided evidence that the Ghost Ant consists of two species: 8.4 % of the samples belonged to the new species T. pithecorum sp. nov. whereas 91.6 % were classified as T. melanocephalum. Absence of mixed samples indicates that T. melanocephalum and T. pithecorum sp. nov. do not represent morphs of the same species. T. pithecorum sp. nov. is known from a greenhouse finding in Germany and outdoor populations from the south of the Arabian Peninsula, Pakistan, India, Malaysia and the Fiji and Christmas Islands. The phenotypical separation of the new species from other minute Tapinoma species of Orientalic, Indo-Australian and Australasian origin is very clear, allowing identification even by evaluation of z-stack photos. A detailed argumentation is presented that Tapinoma pellucida (Smith, 1857), T. coronatum (Forel, 1908), T. malesianum (Forel, 1913), T. australis (Santschi, 1928), T. australe (Santschi, 1928), T. luffae (Kurian, 1955), T. wallacei (Guerrero, 2018) and T. jerdoni nom. nov. should be considered as synonyms of T. melanocephalum. Synomymies of T. melanocephalum and T. pithecorum sp. nov. with T. indicum (Forel, 1895) and Tapinoma minutum (Mayr, 1862) are clearly excluded by morphometric data. Diagrams of principal component analyses, photos, a key as well as a morphometric table to separate these four species are presented. In a concluding section, is argued that the true number of species related to these four species is much larger than presently known and a warning is given regarding careless use of pigmentation characters in ant identification.
Barrier role of wastewater treatment in wastewater disinfection with respect to E.Coli, generalized and total coliform bacteria
Authors: Zagaynova Angelika V. , Zhuravlev Petr V. , Morozova Marina A. , Sedova Darya A. , Gritsyuk Olga V. , Pankova Marina N. , Fedez Zlata E. , Novozhilov Konstantin A. , Yudin Sergey M.
Published: June 2022

Introduction. The work is devoted to the evaluation of the results of own studies of sanitary and microbiological pollution of wastewater in the cities of Moscow, Rostov-on-Don, Azov, Tsimlyansk and the analysis of literature data to justify the list of priority controlled sanitary and microbiological indicators of the safety of decontaminated wastewater that can be discharged into surface water bodies. Materials and methods. Wastewater was studied before and after entering the treatment plant over a 3-year period, including the determination of generalized and total coliform bacteria, sanitary indicative microorganisms, Klebsiella, Pseudomonas aeruginosa, Salmonella and their identification using the MALDI-TOF method and biochemical and serological properties. Results. The sewage waters of the studied cities entering the treatment facilities have a high degree of contamination by generalized and common coliform bacteria, salmonella, the intensity of pollution for which was within acceptable limits at the stage of discharge into surface water bodies according to SanPiN 1.2.3685-21. The number of generalized coliform bacteria exceeded the number of general coliform bacteria, both entering for disinfection and at the stages of purification and entry into surface waters, and their correlation with potentially pathogenic bacteria (PPB) and pathogenic salmonella, in contrast to total (lactose-positive) coliform bacteria, was revealed. Limitations. In the framework of the study, all isolated strains were identified and stored for the study of biological, genetic properties, taking into account the stages of purification, which will be the subject of further research. Conclusion. The index of generalized coliform bacteria retained its indicator significance in relation to pathogenic bacteria Salmonella spp. and made it possible to adequately assess the levels of bacterial contamination of wastewater. At the same time, the economic costs of determining the indicator of generalized bacteria do not differ from the costs of determining the indicators of common coliform bacteria and E. coli. Therefore, for the most adequate assessment of the disinfection of wastewater from treatment facilities, it is advisable to use generalized coliform bacteria as an integral indicator of Enterobacteriales bacteria.
Hygienic assessment of polyurethane coatings in the practice of drinking water supply
Authors: Alekseeva Anna V. , Savostikova Olga N.
Published: June 2022

Introduction. For many years, two-component polyurethane coatings have been used as suitable systems for the protection and reconstruction of pipes in the practice of domestic drinking water supply. However, polyurethane can be a source of pollutants entering drinking water. Special attention in the hygienic assessment is paid to the main components of plastic, the released solvents and film-forming agents used in the formulation of the material. However, the definition of only priority components (taking into account Uniform sanitary requirements) does not provide complete information about the chemical stability of polymer materials during the hygienic assessment. Materials and methods. Eight different two-component polyurethane coatings of various manufacturers and manufacturers offered for use in drinking water supply are investigated in the work. The evaluation of these samples was carried out taking into account Uniform requirements (2010). Indicators that are not mandatory for the evaluation of polymer materials used in drinking water supply were also investigated. Results. Conducting a hygienic assessment of two-component polyurethane coatings shows fundamentally different chemicals to migrate into the model environment even from materials with the same type of components. When analyzing water extracts, from 9 to 40 organic compounds were identified at different temperatures. Most of them do not have the maximum permissible levels of their content in drinking water and there are no fully conducted toxicological studies of these chemicals to assess their safety for humans. There also were found three samples, from which inorganic components of cadmium and nickel migrated into distilled water above their maximum permissible values. Limitations. This study was conducted on the example of polyurethane coatings, as a particular example of the use of polymer materials in drinking water supply. It is necessary to conduct similar studies on other groups of polymers. Conclusion. At the moment, there are certain contradictions in the methodology and approaches to assessing the migration of chemicals from polymer coatings to drinking water. Therefore, their refinement and standardization is relevant, taking into account the increasing share of the use of polymer materials in human life.