bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Impact of Monitoring for Tumor Lysis During Venetoclax Ramp-Up in Chronic Lymphocytic Leukemia in Routine Clinical Practice
Authors: Ghosh Nilanjan , Matusz-Fisher Ashley , Bose Rupali , Boselli Danielle , Magee Gray , Chen Tommy , Hu Bei , Moyo Tamara , Soni Amy , Park Steven , Copelan Edward , Avalos Belinda , Symanowski James , Raghavan Derek , Jacobs Ryan
Published: November 2024

PURPOSE

Venetoclax has made a significant impact in the treatment of chronic lymphocytic leukemia (CLL) due to its ability to induce deep and durable remissions with a finite duration of oral therapy. However, it can lead to tumor lysis syndrome (TLS) which is mitigated with dose escalation strategies. Patients who initiate venetoclax need to follow rigorous, and potentially burdensome, TLS monitoring during dose ramp-up. The frequency with which this rigorous monitoring leads to therapeutic interventions in clinical practice has not been well described. We conducted a study to assess the incidence of TLS and interventions needed after initiation of venetoclax in patients with CLL.

METHODS

Adult patients with CLL who started treatment with venetoclax between July 2017 and March 2021 at Levine Cancer Institute were included in this study. Adherence to the venetoclax package insert (PI) for tumor lysis monitoring, incidence of laboratory as well as clinical TLS, and interventions resulting from the monitoring of TLS were collected.

RESULTS

We report outcomes on 73 consecutive patients with CLL who initiated venetoclax. The majority of patients had low (49%) or medium (44%) tumor burden. During venetoclax ramp-up, 66% of patients adhered strictly to TLS monitoring as per the venetoclax PI. One patient developed laboratory TLS, and no patients developed clinical TLS. Six patients received unplanned interventions to treat TLS; all had medium or high tumor burden. There were no unplanned interventions in patients with low tumor burden.

CONCLUSION

In patients with low and medium tumor burden CLL who start venetoclax, the incidence of TLS is very low, and interventions are uncommonly needed.
Intraprocedural Three-Dimensional Imaging Registration Optimizes Magnetic Resonance Imaging–Guided Focused Ultrasound and Facilitates Novel Applications
Authors: Qiu Liming , Pomeraniec I. Jonathan , Howard Susanna D. , Ajmera Sonia , Bagley Linda J. , Cajigas Iahn , Kennedy Benjamin C. , Halpern Casey H.
Published: November 2024

BACKGROUND AND OBJECTIVE:

Transcranial magnetic resonance–guided focused ultrasound (MRgFUS) has revolutionized ablative treatment of essential tremor in recent years. However, limitations in precision targeting may account for suboptimal efficacy and significant side effects. We describe a simple intraprocedural three-dimensional image-guided lesion shaping technique that can improve overall outcomes of MRgFUS for essential tremor and facilitate expansion to novel indications.

METHODS:

A retrospective review of 84 consecutive MRgFUS procedures performed at Pennsylvania Hospital was performed. Comparison of patient demographics, treatment parameters, and clinical outcomes before and after implementation of this protocol was conducted. Further application of this technique in pallidotomy treatments and ablative disconnection of hypothalamic hamartoma are described.

RESULTS:

After implementation, the median of total number of sonications (7 vs 9, P = .001), number of therapeutic sonications (3 vs 4, P < .0001), and interval time between the first and last sonication (46:10 vs 68:53 minutes, P = .0004) were significantly reduced. Patients expressed greater satisfaction of treatment (94.1% vs 82.4%, P = .018), greater global impression of change (CGI) (7 vs 6, P = .033), and reduced median number of side effects at 6 months (0 vs 1, P = .026). We also successfully implemented this protocol for novel indications.

CONCLUSION:

Intraprocedural lesion shaping for MRgFUS is a simple and versatile imaging protocol augmentation that improves ablation precision and can improve treatment efficacy and broader neurological application.
Digital twin modeling method for environmental governance of abandoned landfills based on multi-agent systems
Authors: Liu Zhansheng , Zhang Zehua , Zhang Qingwen , Zhao Linlin
Published: November 2024

Background It is currently observed that some landfills are experiencing severe overloading, with some having ceased operations. However, they continue to threaten the environment and public health. There is an urgent need for governance, although the process is complex and requires more intelligent and efficient governance approaches. Methods This study explored the application of digital twin technology based on multi-agent systems in the environmental governance of abandoned landfills. This paper addresses the demands of landfill governance by integrating modules, including twin models, mechanisms, and big data, and integrating each module with corresponding intelligent agents, forming a thoughtful, collaborative, and adaptive digital twin agent system. Results This method can collect and analyze on-site data more systematically and provide feedback to management personnel to guide the adjustment of on-site plans and improve the on-site management efficiency by 30%. Conclusions Through application cases, the operation process of this system in specific landfill environmental governance scenarios was demonstrated, confirming its superiority in environmental governance. This system can facilitate environmental monitoring, intelligent analysis, and decision control during the governance of abandoned landfills.
Systematic Review of Air Pollution in Ethiopia: Focusing on Indoor and Outdoor Sources, Health, Environment, Economy Impacts and Regulatory Frameworks
Authors: Redi Tofikk
Published: November 2024

The varied geography (Bekele, 1996) and rapid economic growth of Ethiopia (World Bank, 2020) might have impact its air pollution patterns, with topography, elevation, and climate variability (Lemma Gonfa, 1996) playing significant roles. Environmental challenges, including deforestation and climate change, also affect air quality. This study offers a systematic review of air pollution research in Ethiopia, providing a thorough analysis of its health, environmental, and economic impacts, regional variations, and policy suggestions. It addresses both indoor and outdoor air pollution, assessing their wide-ranging effects. Data were gathered through an extensive search of peer-reviewed articles, policies, and guidelines using Google Scholar and reputable sources, following PRISMA guidelines. The review highlights critical sources of air pollution in Ethiopia, including indoor biomass fuel combustion and outdoor emissions from traffic and industries. Indoor air pollution, particularly from traditional biomass fuels like wood and dung, affects rural and peri-urban areas, leading to high levels of particulate matter and carbon monoxide. Outdoor pollution, driven by urbanization, industrial expansion, and vehicle emissions, worsens health issues and environmental damage. The study identifies severe health consequences, such as respiratory infections and cardiovascular diseases, with air pollution contributing to premature deaths and rising healthcare costs. Economic analysis highlights the significant costs related to healthcare, lost productivity, and infrastructure damage. Environmental impacts include harm to plant health, soil degradation, and contributions to climate change. Despite initiatives to improve air quality monitoring and regulation, challenges persist due to outdated policies, limited infrastructure, and insufficient data. The study emphasizes the need for more comprehensive research and regulations to tackle air pollution crisis.
КЛАССИФИКАЦИЯ ЦЕПЕЙ ПОСТАВОК С УЧЕТОМ ФАКТОРОВ ТРАНСПОРТНОЙ ЛОГИСТИКИ
Authors: Mochalin Sergey M. , Miroshina Irina V.
Published: November 2024

В статье рассматривается логистическая цепь поставок как объект, который классифицируется по определенным признакам, определяются основные классификации, выявляется проблематика отсутствия транспортно-технологических признаков, которые имеют широкое влияние на движение материального потока по логистической цепи поставок.
Цель. Определение классификационных признаков логистической цепи поставок, имеющих учет влияния параметров транспортного процесса.
Метод и методология проведения работы. В статье использовались сравнительные и статистические методы анализа.
Результаты. Среди известных и имеющихся в научном знании классификаций логистических цепей поставок нет такой классификации, которая бы учитывала изменение параметров транспортного процесса при движении материального потока от поставщика к потребителю.
Область применения результатов. Полученные результаты целесообразно применять субъектами, осуществляющими деятельность, связанную с логистикой цепями поставок.
TECHNOLOGICAL DESIGN OF CAR SERVICE STATIONS USING GENETIC ALGORITHMS
Authors: Zakharov Nikolay S. , Kozin Evgeniy S.
Published: November 2024

The study describes the use of evolutionary methods or genetic algorithms for the technological design of newly constructed or modernized car service stations. Genetic algorithms are one of the types of machine learning models and are actively used to solve multifactor optimization problems. A task of this type is to search for the technical parameters of a car service enterprise under which the economic indicators of its activities will correspond to the profit or capital cost restrictions set by the user. The paper presents the parameters of the developed model, fitness functions, and also provides an assessment of the effectiveness of using the method of genetic algorithms relative to the method of simply enumerating different options for combinations of initial factors.
Purpose. Increasing the efficiency of management of road transport enterprises by using the method of genetic algorithms for strategic planning tasks.
Methodology. The research uses the method of genetic algorithms to solve a multi-criteria reverse optimization problem in the technological design of a car service station
Results. The use of the method of genetic algorithms for the design of service stations and enterprises for the maintenance and repair of vehicles is justified, taking into account the restrictions or targets established at the beginning of the design.
Practical implications. The results of the research can be used by the management of enterprises for the maintenance and repair of vehicles in their technological design, strategic planning of activities and modernization.
TRANSPORTATION OF DANGEROUS GOODS
Authors: Lezhnev Anatoly I. , Zabytova Lina M. , Lutsyuk Anastasia N.
Published: November 2024

Transportation of dangerous goods is one of the main directions of logistics, which requires special attention and experience. Professionals working in this field must have a thorough knowledge of chemical products, their properties and classification, as well as the laws and regulations governing their transportation.
The safety of the transportation of dangerous goods also includes strict observance of the rules of conduct in an emergency situation. Prompt response to emerging problems and the use of appropriate tools and equipment to eliminate leaks or incidents are an integral part of the work of professionals in this field. Regular training of personnel and continuous improvement of safety systems are key factors for minimizing risks during the transportation of dangerous goods. Special attention is paid to highlighting the difficulties associated with the transportation of such goods, using the example of individual subjects of the Russian Federation. As a result, comprehensive information on this topic will be obtained, which will allow for a better understanding and management of the risks associated with the organization of transportation of dangerous goods.
Purpose. The purpose is to determine the specifics of the transportation of dangerous goods on the territory of the Russian Federation.
Methodology. In this article, methods of economic, mathematical and statistical analysis were used to achieve the purpose of the study.
Results. This article discusses in detail the key principles and features of the transportation of dangerous goods, which all logistics companies operating in the Russian Federation must follow. Proper compliance with these regulations is a safe and efficient part of the transportation process.
Practical implications. The data obtained can be effectively used by logistics companies specializing in the transportation of dangerous goods to comply with the rules and ensure safety.
Research and Development (R&D): data analysis and cost-effectiveness
Authors: Orlova Ekaterina
Published: November 2024

The textbook outlines the methodological foundations of statistical analysis, modeling and forecasting of data characterizing research and development (R&D) both at the level of individual organizations and at the level of industries and regional systems. Examples of the analysis of empirical data on R&D are given, which allow us to get an idea of the scope of statistical data processing methods in the analysis of real economic processes. A set of methods for the economic justification of R&D projects, depending on their type and stage of the life cycle, is presented. Examples of estimating project costs and other technical and economic indicators are considered, and forecast calculations of the economic efficiency of project implementation are given.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of all forms of education in the fields of Economics and Management. The textbook will also be useful to anyone who deals with the problems of data analysis, modeling the economic efficiency of organizational systems, as well as specialists in innovation management.
A COMBINED APPROACH FOR THE DEVELOPMENT OF COMMUNICATION SKILLS IN PRIMARY SCHOOL STUDENTS
Authors: Isaeva Irina , Odinokova Irina , Kucherova Natalia , Matskevich Valeria
Published: November 2024

The development of communication skills in primary school students is an integral part of the child's adaptation to society. In our work, we explored the possibility of combining gaming technology with the preparation of conference materials and presentation of a report. As a result, positive dynamics of such communication skills as the ability to enter into a dialogue on time, the ability to maintain a dialogue, the ability to end a conversation and the ability to navigate a communication situation were noted.
Dual Training As a Condition for Forming Environmental Competence of Students in the System of Secondary Vocational Training
Authors: Ponomareva M. , Ramazanov R.
Published: November 2024

The system of secondary vocational training in Russia is undergoing significant changes regarding the quality of training of competent specialists who are able not only to carry out professional activities in modern socio-economic conditions, but also to successfully compete in those sectors of the national economy where they will work after graduation. As noted in the state program of the Russian Federation “Development of Education” until 2030, special attention is paid to the development of dual education and environmental education of students. In this regard, since 2014, dual (practice-oriented) training has been successfully implemented in secondary vocational education institutions in the country, within which students acquire basic theoretical knowledge in college classes and acquire practical skills at the enterprise. The purpose of the article is to study ways of developing students’ environmental competence in the system of secondary vocational education. Materials and research methods include an analytical review of scientific research related to the formation of environmental competence in dual learning conditions. The results of the study and their discussion are determined by the choice of approaches, technologies, methods, techniques and forms of work to develop students’ environmental competence. In conclusion, the results of the study are summarized.
Technology of Designing the Module “Career Guidance” of the Working Program of Education of a General Education Organization
Authors: Nechaev Mikhail
Published: November 2024

The article is devoted to the problem of designing the module «Career guidance» of the work program of education of an educational organization. Methodological tips and recommendations for the development of the module under consideration on the basis of the federal work program of education are presented.
Fundamentals of economic security
Authors: Karzaeva Natalya
Published: November 2024

The textbook reveals the main categories and concepts in the field of security, the goals and objectives of the organization of economic security, the functions of subjects of economic security. Special attention is paid to threats and risks, objects, subjects, mechanisms for ensuring industrial, financial, information and personnel security of business entities.
Each chapter contains tests and questions for self-checking the assimilation of educational material, as well as a list of recommended additional literature.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for studying the discipline "Economic security" in the preparation of students of higher educational institutions studying in the field of training 38.05.01 "Economic security" specialization "Economic and legal provision of economic security".
Craniofacial Injuries Resulting from Polytrauma: Mechanisms, Imaging, and Complications
Authors: Porwolik Agnieszka , Porwolik Hanna , Szydłowski Radosław , Bodera Magdalena , Rabstein Dominik , Gościniewicz Piotr
Published: November 2024

Purpose: This literature review aims to identify and analyse the most common mechanisms causing injuries in the craniofacial region their diagnosis and possible sequelae.
Methods: The study analysed publications from the Medline database made available in PubMed and Google Scholar considering the following keywords "maxillofacial injuries" and/or "maxillofacial trauma" and/or "maxillofacial fractures".
Results: Craniofacial injuries in polytrauma patients are often complicated by their heterogeneous nature and coexistence with other injuries. Their incidence and mechanisms vary depending on the country of investigation. Diagnosis includes advanced imaging techniques such as CT scans. Treatment often requires multidisciplinary collaboration.
Conclusions: Craniofacial injuries in polytraumatic patients require a complex diagnostic and therapeutic approach. Interdisciplinary collaboration is crucial to achieve the best clinical outcome. The most common causes include road traffic collisions, assaults, falls and sports-related injuries. Despite properly applied treatment protocols, they generate changes in the stomatognathic system, sensory disturbances, blindness and, in extreme cases, can lead to death
Role of Vitamin D in Allergic Diseases
Authors: Szydziak Joanna Maria , Hrapkowicz Aleksandra , Janowska Kinga , Dąbkowska Daria , Szeidl Olga , Rehan Dominika , Wołoszczak Julia , Mioskowska Agnieszka
Published: November 2024

Introductions: Vitamin D has gained recognition in recent decades not only as a key regulator of calcium and phosphorus metabolism and bone health but also as an important factor modulating the immune system. Research indicates that vitamin D influences both innate and adaptive immune responses, which is significant in the treatment of allergic and inflammatory diseases. Vitamin D has a beneficial effect on asthma exacerbations and may help reduce respiratory inflammation, as well as alleviate symptoms of allergic rhinitis. Vitamin D deficiency may increase the risk of food allergies, worsen symptoms of atopic dermatitis, and contribute to the transition from acute to chronic urticaria. Conversely, supplementation may help prevent allergies, reduce the severity of atopic dermatitis by supporting skin barrier function and antimicrobial peptide production, and relieve symptoms in patients with chronic urticaria.            Purpose of the study: The review article aims to present the current state of knowledge on the role of vitamin D in the treatment of asthma, allergic rhinitis, food allergies, atopic dermatitis, chronic urticaria, and eczema.            Material and methods: To summarize the current knowledge on the topic, a literature review of English language papers with a focus on the most current literature was performed. The review was conducted with the PubMed database with 64 works used, accessed before October 2024.            Conclusions: Although the impact of blood vitamin D levels on the development and progression of allergic diseases has not yet been fully clarified, scientific studies suggest its significant role in modulating immune responses. Due to its immunoregulatory properties, vitamin D offers new hope for more effective treatment and prevention of allergic diseases.
The Powers and Perils of Solitude: Perspectives from Eighteenth-Century French Literature, Religion, and Medicine
Authors: Vila Anne
Published: November 2024

This article examines various meanings of solitude in eighteenth-century Europe, with emphasis on French thought and culture. Part 1 is a survey of literary representations of solitude and contemplation. Part II is devoted to the Jansenist convulsionnaires, Catholic dissidents who took part in a larger appeal against the repressive Unigenitus Bull of 1713. Although the convulsionary movement  sought to attract crowds and publicity, it was also grounded in a Jansenist tradition of spiritual retreat that was emulated by the movement’s de facto patron saint, the appellant deacon François de Pâris. Part III features writings by Zimmermann and Tissot, who medicalized solitude for three reasons: belief in the ethos of sociability, concern over the pathogenic powers of the imagination, and suspicion towards the passions that drove some people to fix their minds exclusively on certain ideas. To show solitude’s harmful consequences for those who spent too much time absorbed in ideas, they made intriguing connections between secular knowledge-seekers and the religiously devout. The Jansenist convulsionnaires were one of the dangerously zealous groups whom they cited to illustrate their arguments.
Pejorativisation of Solitude. A Narratological Deception?
Authors: Domeracki Piotr
Published: November 2024

In this paper I address the problem of the pejorativisation of solitude in philosophical discourse. By the pejorativisation of solitude I mean giving it a negative meaning. I show that the tendency to the pejorativisation of solitude in philosophy was initiated by Aristotle. He saw solitude as contrary to human nature. This nature is supposed to determine people to form organised communities with others. Only through them the individual is able to survive and thrive. In solitude, one quickly learns how inautarkic is and suffers because of it. Thomas Hobbes was one of the first philosophers to challenge Aristotle’s approach. He argued that man strives for community with others not as a result of a supposedly social nature, but because as a child one is dependent and helpless, and as an adult one expects benefits or honours from others. My thesis is that the pejorativisation of solitude is responsible for its negative stereotyping, the formation of prejudices against it and the learned helplessness syndrome, which makes us vulnerable to solitude.
COMMERCIALIZATION OF SCIENTIFIC RESEARCH IN POLAND: PROCESS OR PROCEDURE? ORGANIZATIONAL SOLUTIONS IN SELECTED POLISH AND FOREIGN UNIVERSITIES
Authors: Łaskowska Justyna , Zastempowski Maciej , Kalocińska-Szumska Aleksandra
Published: November 2024

This article aims to illustrate the different ways of organizing commercialization processes at universities to inspire existing technology transfer offices (TTO) and increase their effectiveness. Its implementation was based on a qualitative study conducted among 4 Polish and 2 foreign (Belgian and Spanish) universities. The study results show that the standardized commercialization system doesn’t exist at Polish universities. Research results present that there are many commercialization models, but it is a rather formal procedure than a system or process. Moreover, polish universities perceive TTO as a part of the administration, even if TTO’s employees have ambitions to build merit potential. Finally, the challenge is combining the research process with commercialization to increase efficiency. Our research presents interesting new approaches concerning commercialization: the flipped knowledge transfer (FKT) and the community engagement research initiative (CERI). It is essential to understand that commercialization starts with a research project not with a research result or patent. Both approaches mention before focusing on social engagement in research first and may have an essential impact on TTO’s effectiveness and the university’s social impact. An interesting option is to implement CERI first and evolve it to FKT to perform university research "from the outside to the inside" approach, i.e. undertaking research work in response to stimuli coming from the social and economic environment.
TRADE MARK AS A BRANDING TOOL FOR THIRD GENERATION UNIVERSITY
Authors: Pietrzyk-Tobiasz Barbara
Published: November 2024

Purpose: An overview of how trademarks are used to brand universities and an analysis of global trends in this area.
Methodology: The methodology of the article is based on the basic method used in legal sciences, which is the legal-dogmatic method. In addition, an analysis of the literature on the subject was carried out. Furthermore, within the framework of the article, data on registered trademarks in the databases of intellectual property offices were used.
Findings: The use of trademarks as part of a university's branding and identity is becoming a global trend. An increasing number of universities are choosing to protect their trademarks also within regional and international systems. The use of trademarks is part of the third-generation university model as one focused on communication and cooperation with the socio-economic environment.
Originality/value: The article refers to the realisation by trademarks their functions in the activities of entities that are not directly aimed at generating profit. It attempts to show the relationship between the change in the operating model of universities and the use of distinctive signs in communication with the socio-economic environment.
Keywords: trademark, branding, third generation university
COMPARATIVE ANALYSIS OF THE EVALUATION OF UNIVERSITY COOPERATION WITH THE SOCIO-ECONOMIC ENVIRONMENT ON THE EXAMPLE OF THE REPUBLIC OF POLAND AND THE FEDERAL REPUBLIC OF GERMANY
Authors: Kuliński Mateusz Wojciech
Published: November 2024

Purpose: The purpose of this scientific article is to conduct a comparative analysis of the evaluation of university cooperation with the socio-economic environment, using the examples of the Republic of Poland and the Federal Republic of Germany, and to identify the differences between the analysed systems as a determining factor for the superiority of the German higher education system over the Polish system.
Methodology: Three research methods were employed to achieve the chosen research objective: the formal-dogmatic method (dogmatic-legal), the comparative law method (legal comparativism), and the empirical method (empirical research) as an auxiliary method. The formal-dogmatic method was used to analyse the logical and linguistic regulations governing the institutional framework of agencies responsible for the quality of education in Poland and Germany. The comparative law method will be implemented through classical comparative legal research aimed at analysing the similarities and differences in legal regulations regarding the evaluation of university cooperation with the socio-economic environment in the Republic of Poland and the Federal Republic of Germany. The empirical method was used as an auxiliary method to analyse the thesis presented by the author, which is the superiority of German universities over Polish universities.
Findings: The article points out fundamental differences in the legal status of agencies responsible for the quality of education and the systems of quality evaluation in the area of university cooperation with the socio-economic environment in the Republic of Poland and the Federal Republic of Germany. Furthermore, the author identifies this state of affairs as one of the factors determining the superiority of the German higher education system over the Polish system.
Originality/value: The chosen research objective represents an unexplored field so far. There is a lack of studies in the domestic and European markets that aim to systematically compare the evaluation of university cooperation with the socio-economic environment in the Republic of Poland and the Federal Republic of Germany. The conducted analysis and the resulting conclusions effectively fill this gap.
PROTECTION OF THE ENVIRONMENT – INTERNATIONAL HUMAN RIGHTS AND INTERNATIONAL HUMANITARIAN LAW PERSPECTIVES
Authors: Szpak Agnieszka , Bar Monika , Kemp Eric
Published: November 2024

This review essay outlines, examines and compares two approaches to the environment – the international human rights law approach and the international humanitarian law approach. International community is in the middle of a climate emergency, facing societal collapse and the possible extinction of our species in the future. Hence, we might or we should use any legal weapon we can – including international human rights law and international humanitarian law – to confer as much protection on the environment as we can. The main research questions are: Which of these approaches better protects the environment? Which is closer to the idea that the environment should not only be protected but should have its rights? Where the environment is protected for its value for humans and where for its inherent value? The research methods used in the paper are content analysis of the relevant literature and legal analysis of human rights law and international humanitarian law treaties.
The authors conclude that human rights law approach is more progressive and would offer better protection to the environment, even though it is still anthropocentric. Consequently, a human right to a clean, healthy and sustainable environment has to be anthropocentric. As to international humanitarian law, international policy has a  long way to go before the welfare of the whole ecosystem is adequately recognised and protected in armed conflicts. While international humanitarian law is also anthropocentric and generally neglects to safeguard nature, some principles can be inferred to offer nominal protection in times of conflict at all levels: custom, general principles and treaties.
Kłopoty z kategoryzacją polskich pluraliów tantum
Authors: Nowosad-Bakalarczyk Marta
Published: November 2024

PROBLEMS WITH CATEGORISING POLISH PLURALIA TANTUM
The author of the article discusses problems with the status of the nouns, in contemporary Polish, traditionally classified as pluralia tantum. These problems are mainly related to the Aristotelian model of categorization the essence of which is marking categorial boundaries. Linguistic facts reveal the inadequacy of this approach. An alternative approach is the prototype-based model of categorization, which can accommodate not only those nouns that lack the singular form but also nouns that are similar to them in some respects. This broad understanding of the pluralia tantum category allows one to show the peculiarities of its elements, their unequal status within the category, and the relationship of similarity between them.
Nosowanie i jego synonimy w profesjolekcie logopedycznym, dawnej i współczesnej polszczyźnie ogólnej oraz w gwarach
Authors: Olma Marceli
Published: November 2024

NASALISATION AND ITS SYNONYMS IN SPEECH THERAPY, ANCIENT AND MODERN GENERAL POLISH AND DIALECTS: DESCRIPTION OF A MAN WHO TALKS THROUGH HIS NOSE
The paper belongs to linguistic research devoted to the terminology used in speech therapy. The author discusses lexemes referring to pathological pronunciation accompanied by abnormal nasal resonance. He indicates and discusses words of foreign origin (mainly Hellenisms and Latinisms) as well as using native words taken from dictionaries and studies devoted to the old Polish language and dialects. Moreover, he mentions names referring to a man who speaks indistinctly, through his nose, citing common words and anthroponyms that remain a testimony to the sensitivity and linguistic culture of our ancestors.
Close a Store to Open a Pandora’s Box? The Effects of Store Closure on Sales, Omnichannel Shopping, and Mobile App Usage
Authors: Ye Taotao , Shankar Venkatesh (Venky)
Published: November 2024

This study utilizes a difference-in-differences approach to analyze the causal effects of a store closure on a retail chain’s sales, consumer omnichannel shopping behavior, and mobile app usage.
Retinal and Macular Changes in Pregnant Women of Advanced Maternal Age: A Retrospective Study
Authors: Liu Xintian , Wen Yiyi , Zou Haiqing , Wang Shuangyong
Published: November 2024

Aims/Background Pregnancy may cause physiological and pathological changes in multiple organs in a woman’s body, including the heart, liver, and eyes. With rapid advances in societies and economies, the proportion of advanced maternal age (AMA) women has significantly increased. Here, we aimed to investigate the changes in arteriole retinal diameter, venule diameter, macular layer thickness, and arteriole to venule ratio (AVR) in this population.

Methods This retrospective case-control study included 523 pregnant women (1046 eyes) and was performed on both eyes. In total, 318 subjects were included in the AMA group, and 205 subjects were included in the non-AMA group. Nonmydriatic fundus photography and optical coherence tomography (OCT) were performed on the same day, and the results were analyzed for the central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), AVR, and macular thickness (9 subfields) by integrative vessel analysis and automatic OCT software.

Results In both eyes, the CRAE was significantly lower in the AMA group than that in the non-AMA group (p < 0.05; respectively). The CRVE in the AMA group was higher than that in the non-AMA group (p < 0.001; respectively). Compared to the non-AMA group, the AMA group exhibited a significant reduction in macular thickness within the inner nasal, outer nasal, and inner temporal subfields of both eyes (p < 0.05; respectively). Age was significantly correlated with CRVE and AVR in both eyes of pregnant women (CRVE: p < 0.0001; AVR: p < 0.01).

Conclusion This study reports variations in the diameter of the retinal vasculature and the thickness of the macula in women of AMA. It is important to consider these changes when interpreting the adverse eye outcomes experienced by women of AMA.
New to general practice
Authors: Oxtoby Kathy
Published: November 2024

Starting out in general practice nursing can be daunting. Here are some expert tips and resources on what nurses need to know to work in primary care
Avian macrorhabdosis (Macrorhabdus ornithogaster) causing proventriculitis: Epidemiology, diagnosis, and control
Authors:   Poultry Diseases Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt, El-Ghany Wafaa Abd
Published: November 2024

Macrorhabdosis is a chronic gastric debilitating disease causing loses in most bird’s species. Therefore, this article was designed to outline avian macrorhabdosis disease regarding the incidence, susceptibility, transmission, clinical picture, diagnosis, and control. Macrorhabdosis “formerly megabacteriosis” is a general designation for an important clinically or sub-clinically infectious disease of wild and in-captive companion, psittacin, and passerine birds world wild. Macrorhabdosis is caused by Macrorhabdus ornithogaster (M. ornithogaster) which mainly colonizes the proventriculus close to the proventiculargizzard isthmus. This organism was previously categorized as bacteria, but later it classified as fungus. Infection occurs through ingestion of contaminated feed and water by the droppings or the regurgitation of acute infected or chronic carrier birds. Infected birds M. ornithogaster may appear asymptomatic without signs or show anorexia, depletion, vomiting, diarrhea, and finally death. The lesions mostly constricted to the proventriculus or proventricular/ventricular ismuth as a form of enlargement and thickening with loose koilin layer. Diagnosis of infection is mainly based on microscopic and histopthological examinations and rapid detection of M. ornithogaster using molecular techniques. Application of sanitary and quarantine measures is the must for prevention of infection. Treatment of macrorhabdosis is difficult, however, antifungal and protozoa drugs were satisfactory in certain cases.
Effect of the biological castration vaccine (Improvac®) on sex hormones and reproductive organs of pigs in Vietnam
Authors:   Faculty of Animal Husbandry and Veterinary Medicine, Nong Lam University, Ho Chi Minh City 700000, Vietnam Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA, Lai Danh Cong , Nguyen Nam Minh ,   Research Center for Genetics and Reproductive Health, School of Medicine, National University HCMC, Ho Chi Minh City 700000, Vietnam,   Vietnam National University Ho Chi Minh City (VNU-HCM), Ho Chi Minh City 700000, Vietnam, Vinh Khanh Tran Doan ,   Faculty of Animal Husbandry and Veterinary Medicine, Nong Lam University, Ho Chi Minh City 700000, Vietnam, Thi Hue Vo ,   Zoetis Vietnam company, Ho Chi Minh City 700000, Vietnam, Dai Phong Du ,   Zoetis Vietnam company, Ho Chi Minh City 700000, Vietnam, Do Duy Tien ,   Faculty of Animal Husbandry and Veterinary Medicine, Nong Lam University, Ho Chi Minh City 700000, Vietnam
Published: November 2024

The Improvac® vaccine has been shown to improve growth performance, meat quality, and sexual behavior in swine herds in several countries. This study initially investigated the ability of this vaccine to control sex hormones and the development of reproductive organs in Vietnamese crossbred pigs (Yorkshire – Landrace x Duroc). A total of 45 male piglets were randomly divided into three groups: vaccinated at 12 and 18 weeks old, surgically castrated males at 7 days old, and entire males. Meanwhile, 40 female piglets were randomly assigned to one of two groups: those vaccinated at 12 and 16 weeks of age or entire females. Serum from experimental pigs was collected monthly before and after vaccination until slaughter (25 weeks of age). At the time of slaughter, reproductive organs were obtained to assess changes at the macroscopic and microscopic features. Anti-GnRH antibodies in the immunized male and female pigs increased dramatically and remained for several weeks following a booster shot, while serum levels of sex hormones were significantly lower than in the entire group (P<0.05). In addition, the reproductive organs of the immunized groups were negatively affected compared to the control groups. The male vaccinated group showed a significant reduction in the size of reproductive organs and irreversible disruption of spermatogenesis and testicular structure. The ovary and reproductive organs in the immunized female group revealed degradation in the size and ovarian follicle development. Taken together, the Improvac® vaccine can decrease sex hormones, thereby disrupting the development of reproductive organs in vaccinated male and female pigs.
Hypo-osmotic swelling test discriminates potentially more viable boar spermatozoa diluted using various extenders at different storage times
Authors:   Department of Veterinary Basic Sciences, College of Veterinary Medicine, Visayas State University, Baybay City, Leyte 6521-A Philippines, Peña Jr Santiago T. , Janier Mark Edd B. ,   Department of Veterinary Basic Sciences, College of Veterinary Medicine, Visayas State University, Baybay City, Leyte 6521-A Philippines, Therese Bianca ,   Department of Veterinary Basic Sciences, College of Veterinary Medicine, Visayas State University, Baybay City, Leyte 6521-A Philippines
Published: November 2024

Boar semen samples are normally tested across multiple parameters to ensure maximum performance. However, conventional semen quality parameters may not provide a robust indication of the fertility potential of spermatozoa. This study examined sperm plasma membrane integrity using the hypo-osmotic swelling test (HOST). It was hypothesized that HOST could effectively select possibly more viable spermatozoa despite normality in other parameters. Semen samples (n=15) from five boars were processed into AI doses (~37.5 x 106 spz/mL) using five different commercial extenders: Androstar Plus, BTS, Dilufert Silver, MIII, and VIM. Using Sperm Class Analyzer® CASA system, total and progressive motility, and plasma membrane integrity using dye exclusion test and HOST were evaluated at Day 0, Day 3, and Day 5 of storage. Boar 2 tended to have more HOSTpositive spermatozoa over the other boars in Dilufert Silver, VIM, and Androstar Plus extenders in both Day 3 and Day 5 and in BTS at Day 3. Several significant interactions were also observed when storage times, extenders used, and the kind of boars were considered. Moreover, the total and progressively motile spermatozoa did not vary between boars and different extenders across different storage durations, except for MIII between Day 0 and Day 5. Hypo-osmotic swelling test (HOST) could serve as a useful test for detecting the functional integrity of boar sperm and sensitive enough to discriminate potentially more viable spermatozoa particularly when applied in small-scale swine operations without advanced capacity for comprehensive semen analyses.
Epidemiological characteristics of the ectoparasite infestation in domestic dogs in the Mekong Delta of Vietnam
Authors:   Faculty of Veterinary Medicine, Can Tho University, Ninh Kieu, Can Tho 900000, Viet Nam, - Tran Nguyen-Ho-Bao , Thi La Minh Anh ,   Faculty of Veterinary Medicine, Can Tho University, Ninh Kieu, Can Tho 900000, Viet Nam, Nguyen Bang Phi ,   Faculty of Agriculture and Natural Resources, An Giang University, Viet Nam National University, Long Xuyen City, An Giang 880000, Vietnam, Nguyen Chuc Thi ,   Applied Biology Faculty, Tay Do University, Viet Nam National University, Cai Rang, Can Tho 900000, Vietnam, Nguyen Tri Minh ,   Applied Biology Faculty, Tay Do University, Viet Nam National University, Cai Rang, Can Tho 900000, Vietnam, Lu Tien Ai ,   Faculty of Veterinary Medicine, Can Tho University, Ninh Kieu, Can Tho 900000, Viet Nam, Tran Hanh Huu Thi ,   Kien Giang Vocational College, Rach Gia, Kien Giang 880000, Vietnam, Huu Hung Nguyen ,   Faculty of Veterinary Medicine, Can Tho University, Ninh Kieu, Can Tho 900000, Viet Nam
Published: November 2024

Ectoparasites not only cause pruritus and dermatitis but also play a crucial role in vector-borne disease in domestic dogs. This study aims to investigate the prevalence of ectoparasite infestation and the molecular characteristics of ticks and fleas. A cross-sectional study was conducted on 720 dogs in two provinces and one city in the Mekong Delta of Vietnam: An Giang, Can Tho, and Kien Giang. The identification of ectoparasites was performed based on parasitological methods, conventional PCR, and sequencing. The findings revealed that domestic dogs were infected ectoparasites with a high infection rate of 57.92% (417/720). Age, lifestyle of dogs, and veterinary management practices of dog owners had a significant influence on the ectoparasite infestation in the surveyed dogs. Six different species of ectoparasites were identified by morphological characteristics, including ticks (Rhipicephalus sanguineus), fleas (Ctenocephalides canis, Ctenocephalides felis felis), demodectic mange (Demodex canis), louse (Trichodectes canis), and mites (Sarcoptes canis). In this study, ticks (R. sanguineus) were the most common ectoparasites in infected dogs (59.95%), followed by fleas (Ctenocephalides spp.) at 34.77%, Trichodectes canis at 6.71%, Demodex canis at 2.63%, and Sarcoptes canis 1.92%. Analyzing the 16S rDNA sequence of R. sanguineus in domestic dogs in the Mekong Delta showed high homologs to the R. sanguineus strains from Brazil and India. Furthermore, the ITS-1 sequence of Ctenocephalides revealed a close relationship to the C. canis isolates in Spain.
Antibiotic resistance of Escherichia coli serotype O8 and O9 isolated from cattle in the Mekong Delta, Vietnam
Authors:   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Thuan Nguyen Khanh , Lam Nguyen Thanh ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Phuoc Chien Nguyen Tran ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Kha Ly Thi Lien ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Bich Tran Ngoc ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam
Published: November 2024

This study was conducted to clarify the antimicrobial susceptibility and antibiotic resistance genes of Escherichia coli O8 and O9 isolated from 244 cattle feces collected from December 2021 to March 2022 in the Mekong Delta, Vietnam. E. coli was isolated from the feces following the method of TCVN 7686:2007 (ISO16654:2001), and serotypes O8 and O9 were identified by the PCR method. E. coli O8 and O9 were identified at a relatively high rate, with 15.98% and 8.20%, respectively. The disc diffusion method was applied to determine the antimicrobial susceptibility of those E. coli strains against thirteen antibiotics following the guidelines of the Clinical and Laboratory Standard Institute. Those E. coli O8 and O9 strains showed high susceptibility to amikacin (98.31%), doxycycline (96.61%), ofloxacin (94.92%), and levofloxacin (93.22%). However, those isolates exhibited resistance against ampicillin (47.46%), streptomycin (44.07%), and tetracycline (42.37%). Of those 59 E. coli strains, 35 strains (59.32%) were multiple resistant against two to twelve antibiotics with 25 resistant patterns. The pattern of Am+Ac+Co+Sm+Te+Cl was the most common type (6.78%). The prevalence of six antibiotic-resistance genes was determined by using PCR. Gene tetA was the most prevalent gene (66.10%), while cat1 was the least one (5.08%). Forty-five E. coli O8 and O9 strains (76.27%) harbored from two to four antibiotic resistance genes, and the pattern of strA+tetA+sulII was detected at the highest rate (23.73%). Therefore, the prevalence and antibiotic resistance of E. coli O8 and O9 should be controlled to protect cattle and human health.
Three-dimensional energy-controllable focal spot array with extended depth of focus created by pure phase modulation
Authors: Xiao Jia , Yang Biao , Fan Xiaoyan , Zhi Yilang , Chen Zhi
Published: November 2024

To produce a three-dimensional (3D) energy-controllable focal spot array with an extended depth of focus (EDOF), we propose a pure phase modulation that combines a two-dimensional (2D) pure phase sinusoidal grating (2D PSG) and a light sword optical element (LSOE). The intensity distribution in the 3D focal field is achieved by both simulation and experiment, exhibiting high energy controllability and EDOF. Additionally, the position of the maximum intensity value of any focusing spot exhibits a rotation characteristic, further indicating that the EDOF can be continuously extended. The transverse spacing between adjacent foci, the shape of the focusing spot, and the intensity distribution are achieved in comparison between simulations and experiments, showing good conformity in two situations of f1/f=10% and 20%. Our proposed method paves a new way to produce the 3D energy-controllable focal spot array with EDOF, laying a solid foundation for its application in various fields, such as 3D photonic crystal structures, 3D luminescence, and 3D optical sensing.