bluuebunny/crossref_metadata_2025 huggingface dataset:
Homoeopathic Management of Menopause: A Comprehensive Review
Authors: APHALE DR PARTH , Shekhar Himanshu , Sharma Dr. Dharmendra , Dokania Shashank
Published: September 2024

Background: Menopause signifies a crucial physiological shift in a woman's journey, denoting the halt of menstrual cycles caused by the gradual decline in ovarian activity. Conventional management options, such as Hormone Replacement Therapy (HRT), are effective but not devoid of risks and limitations. In contrast, homeopathy offers a holistic approach to symptom management, aiming to address the underlying cause of menopausal disturbances. Aim and Objective: By critically analyzing clinical studies, randomized controlled trials, and observational research, this paper seeks to elucidate the role of homeopathy as an alternative and complementary therapy for menopause. The objective is to provide insights into the potential benefits of homeopathy and contribute to the growing body of evidence supporting its use in menopausal care. Methodology: A comprehensive search strategy was done to identify relevant literatures from databases such as PubMed, SCOPUS, and Google Scholar. The selection of eligible studies was conducted according to predefined criteria for inclusion and exclusion. Results: Our findings resulted into nine studies that fulfilled the inclusion criteria, including randomized controlled trials, observational studies, and clinical trials. These studies collectively provided evidence of the efficacy of homeopathic medicines in managing various menopausal symptoms, including hot flushes, mood swings, and sleep disturbances. Conclusion: The reviewed literature suggests that homeopathy offers a promising avenue for managing menopausal symptoms, providing an alternative or complimentary approach to conventional therapies. Individualized treatment strategies tailored to each woman's unique symptomatology appear particularly beneficial. However, further clinical trials are needed to fully elucidate the efficacy and mechanisms of action of homeopathic interventions in menopausal care.
Biomechanical parameters of marram grass (Calamagrostis arenaria) for advanced modeling of dune vegetation
Authors: Kosmalla Viktoria , Lojek Oliver , Carus Jana , Keimer Kara , Ahrenbeck Lukas , Mehrtens Björn , Schürenkamp David , Schröder Boris , Goseberg Nils
Published: September 2024

Abstract. This study investigates the biomechanical properties of marram grass (Calamagrostis arenaria, formerly Ammophila arenaria) over a 12-month period on the island of Spiekeroog, Germany, to enhance the modeling of coastal dune dynamics. The research reveals significant seasonal variations in the stiffness and Young's modulus of the vegetation, with higher values observed in winter, crucial for understanding dune erosion processes, and increased flexibility and density in summer, which are important for dune accretion. The findings emphasize the importance of incorporating seasonally adjusted parameters into models, particularly accounting for the increased horizontal density, the presence of flower stems in summer, and the longer leaf lengths in winter. The study also highlights the differentiation among plant parts, with flower stems providing the highest structural support due to their greater stiffness, while leaves contribute more to flexibility and dynamic responses. Interestingly, the minimal differences between green and brown leaves suggest that these can be treated similarly in modeling efforts, allowing for a simplified representation without compromising accuracy. Additionally, the study found no consistent evidence that wind exposure significantly affects the biomechanical properties of marram grass, suggesting that wind influence may not need to be factored into biomechanical models. The results also demonstrate that the biomechanical properties of marram grass are broadly transferable between fixed and dynamic dune systems, supporting the application of these findings across various coastal environments. The key outcome of this research is the detailed compilation of the biomechanical traits of marram grass's aboveground vegetation, reflecting the seasonal dynamics found in dune processes, which will serve as a valuable resource for future modeling efforts of dune vegetation and their surrogates.
Emplacement Age of the Sevier Gravity Slide, Utah, USA
Authors: Rivera Tiffany , Holliday McKenna , Jicha Brian , Malone David H. , Braunagel Michael J. , Bonilla Franco V. Alex , Biek Robert F. , Griffith W. Ashley , Hacker David B.
Published: September 2024

Abstract. The Marysvale volcanic field in southwestern Utah hosts three large volume gravity slides: the Sevier (SGS), the Markagunt (MGS), and the Black Mountains (BGS). The gravity slides are composed of lahar deposits, lava flows, and ash-flow tuffs erupted from former stratovolcanoes and other vents during the Oligocene and Miocene. The ash-flow tuffs are prime targets for dating to constrain the age of the gravity slides because some ash-flow tuffs are deformed within the slides, whereas others are undeformed and cap the slides. Furthermore, the gravity slides produced pseudotachylyte during slide motion, a direct indicator for the timing of each slide. This work provides new 40Ar/39Ar dates for several ash-flow tuffs and pseudotachylyte for the SGS, along with U/Pb zircon dates for one deformed tuff and overlying alluvium at the slide plane. Results show that the slide was emplaced at 25.25 ± 0.05 Ma and was immediately followed by the eruption of the Antimony Tuff at 25.19 ± 0.02 Ma. The model presented here suggests that the intrusion of magma related to the Antimony Tuff acted as a triggering mechanism for the slide, and that slide movement itself led to decompression melting and eruption of the Antimony Tuff. This sequence of events occurred on a geologically rapid timescale and may have been virtually instantaneous.
Measurement report: In-depth characterization of ship emissions during operations in a Mediterranean port
Authors: Le Berre Lise , Temime-Roussel Brice , Lanzafame Grazia Maria , D’Anna Barbara , Marchand Nicolas , Sauvage Stéphane , Dufresne Marvin , Tinel Liselotte , Leonardis Thierry , Ferreira de Brito Joel , Armengaud Alexandre , Gille Grégory , Lanzi Ludovic , Bourjot Romain , Wortham Henri
Published: September 2024

Abstract. A summertime field campaign was conducted in Marseille, one of the major cruise and ferry ports in the Mediterranean to provide comprehensive analysis of in-port ship emissions. High-temporal-resolution data were simultaneously collected from two monitoring stations deployed in port area to examine the composition in both gas and particulate phases. More than 350 individual plumes were captured from a variety of ships and operational phases. Gaseous emissions are predominantly composed of NOx (86 %) and CO (12 %), with SO2 and CH4 each accounting for about 1 %. Although NMVOCs make up less than 0.1 % of the gaseous phase, they can be as high as 10% under specific operational conditions. Submicron particles (PM1) are mainly composed of organics (75 %), black carbon (21 %), and sulphate (4 %) not balanced with ammonium. Among the ship-related characteristics investigated, the operational phase is the most influential with a threefold increase on PM1 emissions, along with higher relative contributions of BC and sulphate, and detection of vanadium, nickel, and iron during “manoeuvring/navigation” compared to “at berth”. Pollutant levels in the port are higher than those found at the urban background site, with average concentrations of NOx, PM1, and particle number (PN) up to twice as high. Analysis of the maximum concentrations reveals pollutants such as SO2 and metals, including Vanadium and Nickel, are 2 to 10 times higher in the port area. This study provides robust support for enhancing source apportionment and emission inventories, both of which are crucial for assessing air, health, and climate impacts of shipping.
Annual memory in the terrestrial water cycle
Authors: Berghuijs Wouter R. , Woods Ross A. , Anderson Bailey J. , Hemshorn de Sánchez Anna Luisa , Hrachowitz Markus
Published: September 2024

Abstract. The water balance of catchments will, in many cases, strongly depend on its state in the recent past (e.g., previous days). Processes causing significant hydrological memory may persist at longer timescales (e.g., annual). The presence of such memory could prolong drought and flood risks and affect water resources over long periods, but the global universality, strength, and origin of long memory in the water cycle remain largely unclear. Here, we quantify annual memory in the terrestrial water cycle globally using autocorrelation applied to annual time series of water balance components. These timeseries of streamflow, global gridded precipitation, GLEAM potential and actual evaporation, and a GRACE-informed global terrestrial water storage reconstruction indicate that, at annual timescales, memory is typically absent in precipitation but strong in terrestrial water stores (rootzone moisture and groundwater). Outgoing fluxes (streamflow and evaporation) positively scale with storage, so they also tend to hold substantial annual memory. As storage mediates flow extremes, such memory also often occurs in annual extreme flows and is especially strong for low flows and in large catchments. Our model experiments show that storage-discharge relationships that are hysteretic and strongly nonlinear are consistent with these observed memory behaviours, whereas non-hysteretic and linear drainage fails to reconstruct these signals. Thus, a multi-year slow dance of terrestrial water stores and their outgoing fluxes is common, it is not simply mirroring precipitation memory, and appears to be caused by hysteretic storage and drainage mechanisms that are incorporable in hydrological models.
Estimation of above- and below-ground ecosystem parameters for the DVM-DOS-TEM v0.7.0 model using MADS v1.7.3: a synthetic case study
Authors: Jafarov Elchin E. , Genet Helene , Vesselinov Velimir V. , Briones Valeria , Kabeer Aiza , Mullen Andrew L. , Maglio Benjamin , Carman Tobey , Rutter Ruth , Clein Joy , Chang Chu-Chun , Teber Dogukan , Smith Trevor , Rady Joshua M. , Schädel Christina , Watts Jennifer D. , Rogers Brendan M. , Natali Susan M.
Published: September 2024

Abstract. The permafrost region contains a significant portion of the world's soil organic carbon, and its thawing, driven by accelerated Arctic warming, could lead to the substantial release of greenhouse gases, potentially disrupting the global climate system. Accurate predictions of carbon cycling in permafrost ecosystems hinge on the robust calibration of model parameters. However, manually calibrating numerous parameters in complex process-based models is labor-intensive and further complicated by equifinality – the presence of multiple parameter sets that can equally fit the observed data. Incorrect calibration can lead to unrealistic ecological predictions. In this study, we employed the Model Analysis and Decision Support (MADS) software package to automate and enhance the accuracy of parameter calibration for carbon dynamics within the coupled Dynamic Vegetation Model, Dynamic Organic Soil Model, and Terrestrial Ecosystem Model (DVM-DOS-TEM), a process-based ecosystem model designed for high-latitude regions. The calibration process involved adjusting rate-limiting parameters to accurately replicate observed carbon and nitrogen fluxes and stocks in both soil and vegetation. Gross primary production, net primary production, vegetation carbon, vegetation nitrogen, and soil carbon and nitrogen pools served as synthetic observations for a black spruce boreal forest ecosystem. To validate the efficiency of this new calibration method, we utilized model-generated synthetic observations. This study demonstrates the calibration workflow, offers an in-depth analysis of the relationships between parameters and synthetic observations, and evaluates the accuracy of the calibrated parameter values.
Review article: The growth in compound weather events research in the decade since SREX
Authors: Brett Lou , White Christopher J. , Domeisen Daniela I.V. , van den Hurk Bart , Ward Philip , Zscheischler Jakob
Published: September 2024

Abstract. Compound events occur when multiple drivers or hazards combine to create societal or environmental risks. Many high-impact weather and climate events, such as simultaneous heatwaves and droughts, are compound in nature, leading to more severe consequences than individual events. This review examines the growth of compound event research in the decade since the IPCC Special Report on Managing the Risks of Extreme Events (SREX) in 2012, which built on existing approaches to highlight the need to better understand compound events. A systematic review catalogues 366 peer-reviewed papers published between 2012–22, revealing an annual average increase of 60 % of papers across the decade, particularly on multivariate (co-occurring) events. Most studies focus on Europe, Asia, and North America, with significant gaps in Africa, South America, and Oceania. The review highlights certain modulators, such as the El Niño Southern Oscillation, and selected event types including compound floods and high-temperature low-precipitation events as the most studied in the literature. The review recommends expanding research in underrepresented regions and studying a broader range of typologies, events, and modulators. It also calls for greater cross-disciplinarity and sectoral collaboration to improve the understanding of compound event impacts and manage the growing risks in a changing climate.
Maximum mouth opening measurement in relation to maximum bite force among children
Authors: Dalya Rafie Mohammed  , MJ Al Haidar Aseel Haidar
Published: September 2024

Objective: This research aimed to study the relation between maximal bite force (MBF) and maximum mouth opening among 12-year-old school children.
Methods: In this cross-sectional study, a total of 400 children aged 12 years (194 boys and 206 girls) were examined. The MBF for the right and left side, as well as the anterior region, were evaluated for all children. The MMO was measured using an electronic digital caliper. To analyze the data path analysis method was used.
Results: Boys showed a higher MMO of 48.797 ± 6.500 than girls (46.710 ± 5.926 mm). The MMO increased with increasing MBF, with significant differences between females and males.
Conclusion: The MMO was higher in boys than in girls. Gender plays a significant role in MBF strength.
Assessment of Iraqi dental practitioners' and undergraduate students' knowledge regarding dentin hypersensitivity management: A cross-sectional study
Authors: Zaidoon Hasan Mohammed  , Thanaa Ghani Nema  , Sohaib Fadhil Mohammed  , Hamsa Zaki Al-Assadi  , Ala Mahdi Muhamed Ali  , Aya Alaa Hussein
Published: September 2024

Objective: The characteristic of dentin hypersensitivity is brief, intense pain that results from exposed dentin in reaction to a variety of stimuli, including mechanical, thermal, osmotic, or chemical factors. This study aimed to evaluate the level of knowledge among undergraduate students and practicing dentists in Karbala City, Iraq, concerning the mechanisms, etiology, and treatment of dentin hypersensitivity (DH).
Methods: 102 surveys were distributed via Google Forms to general practitioners and fourth- and fifth-year dental students at the Kerbala College of Dentistry in Iraq. The data were inputted into Microsoft Excel and analyzed using SPSS 22.0 for Windows as frequency distribution tables and figures.
Results: Despite the differences in comprehension and expertise between students and dentists, a comparative analysis of their responses to various questions revealed several similarities. According to the survey, 28.8% of students reported that 10% of patients suffered from DH, while 32% of dentists reported the same. Additionally, 72% of dentists and 71.2% of students stated that DH is a severe problem for patients. Both dentists, 30%, and 26.9% of students, indicated that DH lasted for less than 2 weeks. According to dentists and students, females are more affected by DH (74%; n=37) and (71%; n=37), respectively.

Conclusion: Students and dentists showed a similar level of knowledge on DH.
Eficacia del tratamiento con biofeedback en la Parálisis Facial Periférica: Revisión sistemática
Authors: Herranz Barroso Sara , Puig Herreros Clara
Published: September 2024

La parálisis facial periférica (PFP) es una lesión aguda en cualquier punto del trayecto del VII par craneal, provocando alteraciones en la musculatura facial. En la actualidad, las técnicas de biofeedback, se emplean para la prevención, evaluación y/o recuperación de la PFP. El objetivo de la presente revisión, fue analizar los efectos que tienen las diferentes formas de biofeedback sobre la sintomatología propia de la PFP y, observar, si la incorporación de la biorretroalimentación resulta igual o más beneficiosa para el tratamiento de esta. Se llevó a cabo una búsqueda bibliográfica en las bases de datos PubMed, ScienceDirect y Web Of Science, a partir del procedimiento PICO y la metodología PRISMA 2020.  Se encontraron un total de 204 artículos, que, tras el proceso de cribado, 12 de los estudios se analizaron cualitativamente. Las técnicas de biofeedback mejoran significativamente la sintomatología de la PFP, permitiendo un mayor control voluntario de la musculatura facial por parte del paciente y, resultan igual o más beneficiosas tanto solas como combinadas con otras formas de intervención, siendo un recurso recomendable en el tratamiento logopédico, ya que, permite una recuperación más rápida y efectiva de la PFP.
2024 İlkokul Türkçe Dersi Öğretim Programı İle 2019 Türkçe Dersi Öğretim Programı’nın Karşılaştırmalı İncelemesi
Authors: Peksöz Muhammet
Published: September 2024

Bu çalışmanın amacı, 2024 ilkokul Türkçe öğretim programı ile 2019 Türkçe öğretim programlarının karşılaştırılarak benzer ve farklı yönlerini ortaya koymaktır. Bu amaç doğrultusunda bu programlar; okuma-yazma süreci, harf grupları, öğretim yapısı, temalar, metin türleri ve sayıları bakımlarından karşılaştırılarak analiz edilmiştir. Araştırmada nitel araştırma yöntemlerinden olan doküman inceleme tekniği kullanılmıştır. Araştırmanın veri toplama araçlarını, 2024 ilkokul Türkçe öğretim programı ve 2019 Türkçe öğretim programı oluşturmaktadır. Araştırma sonucunda, her iki programda da ilk okuma yazma yöntemi, tema sayıları, temalardaki metin sayıları yönünden benzerlik gösterirken 2024 programının 2019 programına göre bazı farklı yönlerinin de olduğu görülmüştür. Buna göre 2024 programında; okuma yazma sürecinde eklemelerin olduğu, harf grupları ve yazı defterinde değişikliklere gidildiği, kazanım ifadesi yerine öğrenme çıktıları ifadesinin kullanıldığı, zorunlu temaların kaldırıldığı, öğrenme çıktılarının sınıf seviyesiyle doğru orantılı şekilde arttığı, metin türlerinde çeşitliliğin arttığı tespit edilmiştir.
Primary T-Cell Lymphoma of the Prostate in a Dog – Case Report
Authors: Costa Marina Laudares , Fonseca-Alves Carlos Eduardo , Oliveira Gustavo Garkalns de Souza , Nakage-Canesin Ana Paula Massae , Rezende Paula Christine Bonadio , Demarchi Munhoz Thiago
Published: September 2024

The prostate gland is considered an accessory sexual organ of the male reproductive system which in dogs can vary in size influenced by age, weight and breed. The most frequent anomalies found in the canine prostate are due to Benign prostatic hyperplasia, prostatitis, abscesses, prostatic and paraprostatic cysts, squamous metaplasia and prostate neoplasia in adult and geriatric dogs. Prostate lymphoma, unlike some neoplasms, is not routinely seen. An abnormal prostate is presumptively diagnosed based on the patient’s history and clinical signs, blood markers and abnormal anatomical outline detected on palpation and imaging. The present report describes the case of a 13-year-old male, 26 kg, intact dog, referred to the Centro Universitário Barão de Mauá Veterinary Campus manifesting dysuria and diagnosed with primary prostatic lymphoma.
UNEMPLOYMENT IN SLOVAKIA DURING THE COVID-19 PANDEMIC
Authors:   Alexander Dubček University of Trenčín, Masárová Jana , Koišová Eva ,   Alexander Dubček University of Trenčín, Krajčo Karol ,   Alexander Dubček University of Trenčín
Published: September 2024

Labour market developments have been on a positive trend in recent years. Employment and unemployment were not projected to change significantly. The advent of the COVID-19 pandemic halted this trend. The labour market, the economies of countries and their governments have been exposed to new challenges. In our paper, we focus on the evolution of employment and unemployment in the first to third waves of the pandemic in the Slovak Republic. We focus on a time series analysis of labour market developments by education, last occupation and sectors of industry. The above analysis may serve to further investigate this issue in the future and to track developments over a larger time period.
PRECARIOUS WORK IN PANDEMIC COVID-19 - WORK STATUS PERSPECTIVE
Authors:   Alexander Dubček University of Trenčín, Havierniková Katarína , Okręglicka Małgorzata ,   Czestochowa University of Technology
Published: September 2024

The COVID-19 crisis has caused drastic changes in the labor market in almost every country, increasing job insecurity at various levels, both in terms of employment and the type of contract with the employer, as well as working conditions. Under these conditions, the concept of precarious employment takes on a new meaning. The main aim of this study was to evaluate how the COVID-19 pandemic affected the labor market in the Slovak republic with particular emphasis on changes in the work status in the face of the pandemic crisis. The Descriptive Statistic, Student’s t-test, and Chi-square Independence Test was used to evaluate data. The results of the realized analysis showed that the changes in the labor market were significant after April 2020. The stabilization of the rate of unemployment occurred in the summer of 2021. The Slovak Republic has introduced many strict measures to prevent the pandemic's spread, but it has caused a significant increase in unemployment with noticeable differences among Slovaks regions. The results of the questionnaire survey confirmed that in the early phase of the pandemic, job changes began to occur, and the number of home-office job offers increased.
EFFECTIVENESS OF JUST-IN-TIME PRINCIPLE IN TODAY´S CIRCULAR ECONOMY AND ITS NEGATIVE EFFECT
Authors:   School of Expertness and Valuation, Institute of Technology and Business in České Budějovice, Kalinová Eva , Kostečková Denisa ,   School of Expertness and Valuation, Institute of Technology and Business in České Budějovice
Published: September 2024

In the context of circular economy, manufacturers aim to improve the quality of the environment and human life. With regard to the nature of their production, business entities within circular economy adopt the philosophy of the Just-In-Time method. This paper analyses the impact of this method on the current supplier-customer relations in the Czech Republic as well as the quality of fulfilment of its obligations. Moreover, it is evaluated whether the concept of Just-In-Time method is suitable for efficient functioning of this economy. Based on the data obtained, a comparison analysis of the research problem is performed. The level of meeting deadlines for supplies in the manufacturing process of a domestic business entity is examined. The analysis performed did not confirm the idea of combining speed with the adaptive response to change. In the Czech Republic, the Just-In-Time method is currently influenced by a number of negative factors, which significantly affect the current supplier-customer relations and the quality of fulfilment of their obligations. The key factors affecting the effectiveness of the Just-In-Time principle include the extension of the stock replenishment period and inaccurate logistics cooperation in the area of production planning.
TECHNOLOGIZED SOCIETY LIQUID POWER, LIQUID EDUCATION AND LIQUID CAREERS
Authors:   Faculty of Arts, Palacký University Olomouc, Kořen Vojtěch
Published: September 2024

This text is a critical - but not criticizing - essay focused on issues of the impact of technologization, globalization and liquid capitalism on the world of work and education. It is divided into four separate parts. The first part (From industrialization to technologization) deals with the definition of the key categories, which are industrialization, industrial revolution and technologization. The second part (Fluidity and Power) deals with the issue of Bauman's fluid modernity and related phenomena, which are fluid capitalism, globalization and changes in area of the division of labor. The third part (Liquid Education) is an analytical insight into the impacts of wider societal changes to the values in education, educational goals and the content of education in liquid capitalism. The last (4th) part (Liquid of work and occupation, liquid careers) deals with the changes of work and career in liquid modernity. The aim of the text is to provide a reminder, among other things, that despite the great respect for technological ability, intelligence and complexity of many engineers and technologists who create advanced robots (hardware but also software), issues of morality, ethics, culture, emotions and values belong in the hands of fields other than ICT. Even this still sovereign area of humanity is influenced by the advancing technologization of our society.
Applying TOPSIS to selecting business accounting software: A case study at Truong Son Technology Development Investment Joint Stock Company
Authors: Nguyen Thi Thanh Loan , Tran Thi Nga , Nguyen hi Hong Nga , Bui Thi Quyen , Nguyen Thi Thanh Huong
Published: September 2024

This study aimed to build a model and set of criteria to evaluate and select business accounting software providers for Truong Son Technology Investment and Development Joint Stock Company. The study helped choose the most suitable supplier that meets the criteria that the company desired. The research proposed the Technique of Order Preference Similarity to the Ideal Solution (TOPSIS) model and was also applied in the case of selecting accounting software suppliers for Truong Son Technology Investment and Development Joint Stock Company. There were 5 business accounting software packages considered: Misa business accounting software, Bravo accounting software, FAST Accounting software, Effect accounting software, and Gamma accounting software. The ranking results of accounting software providers at Truong Son Technology Investment and Development Joint Stock Company were as follows: A1 (Misa Business Accounting Software) was the best supplier, second-ranking was A3 (FAST Accounting software), followed by A2 (Bravo Accounting Software) in third place. The findings of this study could be used as a valuable reference for businesses to choose the best supplier.
Relationship between renewable energy consumption and its impact on CO2 emissions in Peru, 1990-2020
Authors: Salvador Joselyn Dayana Tica , Cano Raúl Camayo , Jimenez Dante Manuel García
Published: September 2024

In his research, he has established an analysis of the consumption of renewable energy and its impact on CO2 emissions in Peru, 1990-2020. The research employs a quantitative approach and longitudinal non-experimental design, with a multiple linear regression model. It uses time series drawn from the World Bank on renewable energy consumption and energy consumption. A progressive increase was reflected mainly driven by industrial growth, fossil fuel consumption and changes in consumption and production patterns.
Energy-efficient scheduling for a flexible job shop problem considering rework processes and new job arrival
Authors: Albayrak Emrah , Önüt Semih
Published: September 2024

Sustainable production is not limited to environmental concerns only; It also provides economic benefits for businesses. Businesses that adopt sustainability principles can gain advantages in matters such as cost savings, competitive advantage, risk management, legal compliance and corporate reputation. Therefore, sustainability is no longer an option but a strategic imperative for businesses. For this reason, studies on energy-sensitive scheduling have started to increase recently. Another important factor in sustainable manufacturing is the reduction of scrap. Rework operations are required to reduce scrap. In this study, the multi-objective flexible job shop scheduling problem (MO-FJSP) that considers energy efficiency is discussed. The created model aims to minimize the energy consumption, total machine workload and makespan. In this study, new job arrivals are considered as dynamic events. Another dynamic event added to the model is the addition of rework processes between operations to reduce the scrap rate when a scrap decision is made during the production stages. The enhanced NSGA II algorithm was applied to solve this problem. The enhanced NSGA II algorithm was applied to test instances and its performance was compared using some of the multi-objective performance indicators. These experimental results prove the effectiveness of the proposed solution method.
Stability Indicating Method Development and Validation for Estimation of Valacyclovir in Pharmaceutical Preparation
Authors: S. Chalikwar Shailesh , K. Moravakar Kailas , A. Bhairav Bhushan
Published: September 2024

Valacyclovir is an antiviral drug that is frequently administered to treat herpes simplex and herpes zoster infections. A simple, rapid, and accurate method for quantifying valacyclovir hydrochloride in tablet and bulk form has been developed. Two distinct analysis approaches, UV and HPLC, were developed in the present study for the evaluation of valacyclovir hydrochloride in pharmaceutical preparation. The mobile phase employed in the UV technique was Methanol:10mM KH2PO4 Buffer (50:50) for estimation of the drug at 254nm, and the (VAL) achieved was 99.45%. The method's validation was completed in accordance with ICH Q2 R1 standards, and linearity was found in the 9–45g/ml range with a regression value of 0.997% and RSD values of accuracy, precision, and robustness that were less than 2. In the HPLC method, the estimation of (VAL) was assessed on a Cosmosil C-18 (250mm4.6ID, Particle size: 5) column with Methanol:10mM KH2PO4 Buffer (50:50), 1 ml/min of flow rate, detection wavelength of 254nm, and the time of retention observed to be approximately 5.03 minutes with the assay value of 99.56%. Additionally, the HPLC technique was verified in accordance with ICH standards, and linearity was found in the 10–50g/ml range with a regression coefficient value of 0.998. Precision, accuracy, and robustness all had RSDs that were under 2%. Using Methanol:10mM KH2PO4 Buffer (50:50), the HPLC technique was also used to evaluate forced degradation at 254nm. It is clear from this study that the proposed methods for valacyclovir estimate in pharmaceutical preparation are quick, efficient, and specific. They may also be applied in routine analysis for the quantification of the drug in a dosage form.
RP-HPLC Method Development and Validation for the Etonogestrel and Ethinyl Estradiol in Pharmaceutical Dosage form
Authors: Bodagala Pavithra , Divya Y , Parthiban C , Sudhakar M
Published: September 2024

A simple, Accurate, precise method was developed for the simultaneous estimation of the Ethinylestradiol and Etonogestrel in pharmaceutical dosage form. Chromatogram was run through BDS C18 150 x 4.6mm, 5. Mobile phase containing Buffer 0.01N Na2HPO4: Acetonitrile taken in the ratio 70:30 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was NA2HPO4 Buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 230nm. Retention time of Ethinylestradiol and Etonogestrel were found to be 2.163 min and 2.824. %RSD of the Ethinylestradiol and Etonogestrel were and found to be 0.8 and 0.5 respectively. %Recovery was obtained as 100.20% and 100.55% for Ethinylestradiol and Etonogestrel respectively. LOD, LOQ values obtained from regression equations of Ethinylestradiol and Etonogestrel were 0.03, 0.10 and 0.01, 0.02 respectively. Regression equation of Etonogestrel is y = 19522x + 504.57, and y = 27207x+358.27of Ethinylestradiol. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
An Updated Review on Analytical Method Validation of Tartaric Acid from Sodium Bicarbonate, Sodium Citrate, Citric Acid and Tartaric Acid Granules by RP-HPLC
Authors: Gosavi Seema , Nanaware Rushikesh
Published: September 2024

The purpose of this work was to develop and validate an appropriate analytical technique using RP-HPLC in conjunction with organic acids and (C4H6O6) tartaric acid. For the quantitative measurement of tartaric acid, sodium bicarbonate, sodium citrate, and tartaric acid granules, a straightforward, sensitive, and reliable technique was created. For the quantitative analysis, reverse-phase and 210nm UV/visible detectors were discovered and used. For this decision, an easy isocratic procedure was questioned. With the aid of (H3PO4) orthophosphoric acid, the optimal mobile phase was (KH2PO4) 0.01M potassium dihydrogen phosphate, which had a pH of around 2.6. The pH balance is maintained with orthophosphoric acid. The chromatographic conditions for the best separation of tartaric acid, RP-column C18 Shimadzu GIST Shim pack (4.6mm x 250mm, 5um) with a flow rate of 1ml, wavelength of 210nm, and injection volume of 20 l. The oven is set to a temperature of around 30 °C, and the RP-HPLC method takes about 15 minutes to complete.
A State-of-the-Art Review on Chromatographic Analysis of Alcaftadine
Authors: G. Jain Tejas , R. Dhankani Amitkumar , Pawar S. P. , A. Dhankani VMansi
Published: September 2024

This paper provides an extensive overview of chromatography techniques utilized in the analysis of Alcaftadine, a pharmaceutical compound used in ophthalmic formulations. Various chromatographic methods including UV Spectrophotometric, HPLC, RP-HPLC, HPTLC, and UPLC have been developed and validated for the accurate quantification of Alcaftadine in bulk and dosage forms. The methods described offer specific advantages such as ease of use, precision, and sensitivity, ensuring reliable results in pharmaceutical analysis. Key parameters of method validation, including accuracy, precision, linearity, limit of detection, limit of quantitation, specificity, range, and robustness, are comprehensively discussed, highlighting the stringent criteria required for analytical method validation in accordance with regulatory guidelines. The importance of stability-indicating methods for assessing the stability of Alcaftadine formulations is emphasized, underscoring the need for robust analytical techniques to ensure product quality and efficacy. The review underscores the crucial role of chromatography in pharmaceutical research, providing valuable insights for researchers and practitioners involved in drug development and quality control.
A Review on Sample Preparation for Bio analytical Method Development by HPLC
Authors: Ravi Kumar Pola , Tejaswi Pamarthi , Koppera Sowmya , Neha Mundru
Published: September 2024

This article compares the benefits and drawbacks of each approach while reviewing recent advancements in bioanalysis sample preparation methods. It also provides an update on fundamental concepts, theories, applications, and automation opportunities. Because every biological matrix has its own special difficulties and complexity, sample preparation is thought to be the bottleneck stage in bioanalysis. In the last ten years, new sample preparation methods for bioanalysis have developed quickly. In the preclinical and clinical phases of drug development, it is crucial to create reliable bioanalytical method(s). Consequently, it is widely acknowledged that sample preparation A number of excellent review papers have recently been published in the literature that address various scientific and technical facets of bioanalysis. The use of bioanalysis in the pharmacokinetic/pharmacodynamic characterization of novel chemical entities, beginning with their finding and continuing through their market authorization, is now generally acknowledged. Physico-chemical and biological technologies used in bioanalysis, including mass spectrometry, immunoassay, and chromatography. Liquid chromatography-mass spectrometry is a method used in labs for the qualitative and quantitative study of drug substances and metabolites. It makes use of liquid chromatography/RP HPLC. The current review concentrated on different extraction methods, including protein precipitation, solid phase extraction, and liquid-liquid extraction, all of which are crucial for sample preparation and RP HPLC sample detection.
From scalar to tensor finite elements
Authors: Gopalakrishnan Jay
Published: September 2024

In the history of finite elements, the earliest Lagrange finite elements, consisted of scalar-valued functions. To approximate fluxes, vector-valued finite elements with continuous normal (n) components across element interfaces, or n-continuous elements, were developed later. The finite element toolkit was then supplemented by t-continuous vector-valued Nedelec elements with continuous tangential (t) components, now routinely used for Maxwell equations. Although these elements were developed separately, today we understand them together as fitting into a cochain subcomplex of a de Rham complex of Sobolev spaces. Other tensor-valued finite elements are now being viewed with increasing interest and they form the main subject of this talk. The earliest of these consists of matrix-valued functions whose normal-normal (nn) component varies continuously across element interfaces: these are the nn-continuous matrix fields of the Hellan-Herrmann-Johnson element. More recently, nt-continuous matrix-valued finite elements were developed to approximate viscous stress in incompressible flows: they have continuous shear, or normal-tangential (nt) components. To add to this picture, matrix-valued elements with continuous tangential-tangential (tt) components, called Regge elements, are finding increasing utility: they are key to approximating the metric tensor of Riemannian manifolds. This talk delves into the details of these developments. How does one connect these disparate developments with nn-, nt-, and tt-continuous matrix finite elements? This does not appear to be as easy as the previous synthesis of vector-valued elements by the de Rham complex. The spaces in de Rham complexes are connected by fundamental first-order differential operators (grad, curl, and div in three dimensions), all derived from a single definition of the exterior derivative. In contrast, what is natural for the above-mentioned tensor finite elements are other second-order differential operators. We conclude grazing the frontiers of our understanding on potentially unifying connections. This initiative is part of the “Ph.D. Lectures” activity of the project "Departments of Excellence 2023-2027" of the Department of Mathematics of Politecnico di Milano. This activity consists of seminars open to Ph.D. students, followed by meetings with the speaker to discuss and go into detail on the topics presented at the talk.
Beneath the Veneer: The Stealthy Pervasiveness of Anti-Black Racism in a Purportedly Colorblind Society
Authors: Reck Paul , McAuley Chris
Published: September 2024

This talk will encompass:
1) What anti-Black racism involves and the contexts in which it is ripe;
2) The assumptions about Blacks in contrast to Whites that undergird these racist practices;
3) Why it is often difficult for people to identify and challenge these practices.

Paul Reck is the author of [*How Interpersonal Interactions with Young Black People Forever Altered a White Man’s Understanding of Race*](https://livedplacespublishing.com/book/isbn/9781915734211?utm_source=MB utm_medium=cassyni utm_campaign=black-studies utm_content=Reck), published by Lived Places Publishing.
Pyrolytic Syntheses of N-Doped Solid Base Metal Catalysts for the Production of Amines
Authors: Topf Christoph , Michalke Jessica
Published: September 2024

This presentation delves into advanced catalyst design, with a particular emphasis on heteroatom doping. The supported hydrogenation catalysts exhibited significant activity in both reductive amination and nitroarene reduction, applicable in batch and continuous-flow processes. Preparation involved applying air-stable, non-precious, molecularly defined precursors onto support materials via wet impregnation, followed by pyrolytic activation. A strong focus was placed on material recyclability. Detailed structural and thermal analyses, conducted using TGA, XPS, EDX, and STEM techniques, provided deep insights into surface morphology and behavior under varying conditions.
THE EFFECTS OF PRICE AND VOLATILITY INDICES OF STRATEGIC COMMODITIES ON STOCK MARKETS: A STUDY ON BRICS ECONOMIES
Authors: Saka Ilgın Kübra , Güney Selami
Published: September 2024

The effect of gold, oil prices, which are strategic commodities, and gold, oil volatility indices on the BRICS stock exchanges is investigated in this paper. The relationship between the variables is analysed for the short and long-run using the NARDL method. Gold prices have a negative effect on stock markets except Brazil and Russia, in the short and long-run. Changes in oil prices have a negative effect on stock prices in South Africa, which imported oil, and a positive effect in net oil exporters Brazil and Russia, in the short and long-run. It is concluded that positive and negative shocks of strategic commodity volatilities have an asymmetric effect on the stock exchanges of emerging countries in the short and long-run.
VIX ENDEKSİNDEN FİNANSAL YATIRIM ARAÇLARINA DOĞRU GETİRİ VE VOLATİLİTE YAYILIMI: COVID-19 ÖNCESİNE VE SONRASINA YÖNELİK KARŞILAŞTIRMALI BİR ANALİZ
Authors: Yıldız Enes , Polat Müslüm
Published: September 2024

Uluslararası piyasa koşullarının daha iyi anlaşılabilmesi ve uygun risk yönetimi stratejilerinin uygulanabilmesi açısından beklenen piyasa volatilitesinin finansal varlıklar üzerindeki etkisinin belirlenmesi önem arz etmektedir. Bu çalışmada, ABD pay piyasasının 30 günlük beklenen volatilitesini ölçen VIX endeksinden altın, petrol, Dolar kuru, faiz oranı ve S&P 500 endeksine doğru getiri ve volatilite yayılımları, Covid-19 öncesi ve sonrası dönemler için çok değişkenli VAR-EGARCH yöntemi kullanılarak incelenmiştir. Analizler sonucunda, Covid-19 öncesinde, VIX endeksinden petrole ve faiz oranına doğru getiri yayılımları elde edilmesine rağmen Covid-19 sonrasında, bu aktarım mekanizmalarının zayıfladığı görülmüştür. ABD Dolar endeksinde ise, bunun tam tersi bulunmuştur. Ayrıca, Covid-19 sonrasında, VIX endeksinden ABD Dolar endeksine doğru volatilite yayılımları saptanmıştır. VIX endeksinden S&P 500 endeksine doğru getiri ve volatilite yayılımlarının ise, her iki dönem için de mevcut olduğu gözlemlenmiştir.
BIST SÜRDÜRÜLEBİLİRLİK 25 ENDEKSİNDEKİ ŞİRKETLERİN SÜRDÜRÜLEBİLİRLİK KONUSUNA YAKLAŞIMLARI
Authors: Gürsoy Çiğdem , Özuyar Pınar
Published: September 2024

Son dönemlerde önemi gittikçe artan sürdürülebilirlik kavramı artık şirketlerin yıllık raporlarında yer bulmaktadır. Birleşmiş Milletlerin 2030 Sürdürülebilir Kalkınma Amaçlarını (SKA) yayınlamasının ardından raporlar verilen amaçlar doğrultusunda revize edilmeye başlanmıştır. Şirketler iş planlarını SKA gözeterek oluşturduklarında kavrama mesafeli şirketlere göre finansal performansları, toplumsal faydaya katkıları ve çevre hassasiyetleri üst düzeyde olmuştur. Çalışmanın amacı; Borsa İstanbul’da yeni bir finansal araç olarak oluşturulmuş BIST Sürdürülebilirlik 25 Endeksi’nde yer alan şirketlerin finans, topluma katkı ve çevre konusundaki davranışlarını irdelemektir. Bu amaçla, listedeki şirketlerin GRI dahil sürdürülebilirlik raporları, şirket internet sayfaları ve BM Küresel İlkeler Anlaşması’nı kabul durumları gibi kamuya açık beyanlarından yola çıkılmıştır. İş süreçlerini ve bilgi paylaşımlarını SKA ile entegre eden şirketlerin daha şeffaf, hesap verilebilir ve güvenilir olma yolunda çaba gösterdikleri tespit edilmiştir.
Conferencia dictada en la Casa de la Cultura Ecuatoriana “Benjamín Carrión”, Núcleo del Guayas el 24 de mayo de 2006
Authors: Romero Vicuña Miguel
Published: September 2024

Se hace una descripción integral del origen y evolución psicofisiológica de los arquetipos del inconsciente colectivo que son los prototipos de las ideas y modelos eternos de las cosas y que vienen programados en los genomas hereditarios de cada uno de los seres vivos de la tierra. Las plantas nacen con sus programas biocibernéticos basados en modelos arquetípicos biológicos y desarrollan sus programas biológicos propios de cada especie. Los animales heredan sus arquetipos biológicos de comportamiento que son exclusivos para cada especie. Y según Jung, los arquetipos en el hombre son formas típicas de conducta hereditaria de carácter universal que, cuando llegan a ser conscientes, se manifiestan como representaciones y experiencias, al igual que todos los que llegan a ser contenidos de la conciencia
El Lenguaje Arquetipico
Authors: Romero Vicuña Miguel
Published: September 2024

Se hace una descripción integral del origen y evolución psicofisiológica de los arquetipos del inconsciente colectivo que son los prototipos de las ideas y modelos eternos de las cosas y que vienen programados en los genomas hereditarios de cada uno de los seres vivos de la tierra. Las plantas nacen con sus programas biocibernéticos basados en modelos arquetípicos biológicos y desarrollan sus programas biológicos propios de cada especie. Los animales heredan sus arquetipos biológicos de comportamiento que son exclusivos para cada especie. Y según Jung, los arquetipos en el hombre son formas típicas de conducta hereditaria de carácter universal que, cuando llegan a ser conscientes, se manifiestan como representaciones y experiencias, al igual que todos los que llegan a ser contenidos de la conciencia. Entre los principales arquetipos que tiene el hombre están: los arquetipos biológicos a la sombra, al animal, al anciano, al sabio, (patriarca, profeta), a la trascendencia, a la mesianidad, a la muerte, al ánima, al ánimus, a los mitológicos, sociológicos, religiosos y filosóficos.
Se hace también una descripción de la forma como se originan y evolucionan los procesos psicobiológicos en el niño en base a los arquetipos colectivos; pues en el inconsciente humano existe un universo parecido al cosmos, en donde brillan el sol, la luna, las estrellas y las galaxias, que son los símbolos orales en el hombre, provocados por el trauma oral del recién nacido, y que estriba en la alucinación visual que aparece en un estado de inanición, sed y hambre durante la época de lactancia. Finalmente se hace un estudio de los arquetipos mayores, que son contradictorios y paradójicos y que giran alrededor de las cualidades humanas del bien y del mal. Con esto los autores demuestran que las imágenes arquetípicas que sin ser dioses proyectados en el cielo de la conciencia universal constituyen las verdaderas imágenes de lo que fuimos, somos y seremos en el futuro.
El régimen constitucional del buen vivir y del empoderamiento ciudadano
Authors: Garaicoa Ortiz Xavier
Published: September 2024

El nuevo régimen político-constitucional que se deriva de la carta de Ciudad Alfaro aprobada mediante referéndum (2008), configura un Estado de derechos y justicia, cuyos elementos más salientes serían un sistema de derechos e instituciones designados como del "buen vivir" (Su- mak Kawsay) sustentado en la plurinacionalidad e interculturalidad, y, un proceso legitimador democratizante de empoderamiento participativo de la ciudadanía. A diferencia del Estado legalista-administrativo de Derecho y del Estado social asignador, el mismo requiere una dinámica sistémica y una concepción de justicia esencial y no tan sólo material. Estos serían los retos para alcanzar una ciudadanía democráticamente construida en su pluralidad y diversidad, examinados en el trabajo.