bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Earnings Management and Financial Performance on Stock Returns Ahead of the Initial Public Offering with Company Size as Moderating Variable
Authors: Ratnasari Dwi Ika , Widodo Heri
Published: January 2023

This study aims to determine the effect of earnings management and financial performance on stock returns, with firm size as a moderating variable (Study of Companies Listed on the Indonesia Stock Exchange in 2017-2020). The variables in this study use independent variables, dependent variables and moderating variables. The independent variables of the study are earnings management and financial performance. The dependent variable of the study is stock returns. The research moderating variable is firm size. This study uses a quantitative approach. The research sample was taken using a non-probability sampling method with purposive sampling technique, with a total sample of 166 companies. This study uses SEM (Structural Equation Model) analysis in testing the research hypothesis. strengthen the effect of financial performance on stock returns.
The Influence of Education Level, Work Experience and Work Environment on Employee Performance
Authors: Anggita Vierlyana , Indayani Lilik
Published: January 2023

This research is a quantitative research, and the location of this research is PT Karindo Putra Jaya. The population in this study were all employees of PT Karindo Putra Jaya, totaling 283 employees. The sample used is 100 respondents, using a probability sampling technique that is carried out by cluster sampling. Using questionnaires, interviews and unstructured observations to collect data. With the help of SPSS data processing software, multiple linear regression was used for data analysis. The results showed that the level of education had a partial effect on the performance of PT Karindo Putra Jaya employees, work experience had a partial effect on the performance of PT Karindo Putra Jaya employees, the work environment had a partial effect on the performance of employees of PT Karindo Putra Jaya. partially on the performance of employees of PT Karindo Putra Jaya and the level of education, work experience and work environment have a simultaneous effect on the performance of employees of PT Karindo Putra Jaya.
The Influence of Brand Trust, Brand Affect, Service Quality on Purchase Decisions at Rooster Coffee Sidoarjo
Authors: Julianto Rachmat , Indayani Lilik
Published: January 2023

This study aims to determine the effect of Brand Trust, Brand Affect and Service Quality on Purchase Decisions at Rooster Coffee Sidoarjo. This research is a descriptive study using quantitative methods. data retrieval technique is by distributing questionnaires to consumers who have visited Rooster Coffee as many as 100 respondents. The analysis technique used in this study is multiple linear regression using SPSS version 22 for windows. The results of this study indicate that the Brand Trust variable affects purchasing decisions, the Brand Affect variable affects purchasing decisions and the Service Quality variable affects purchasing decisions on Rooster. Coffee Sidoarjo.
The Influence of Digital Marketing, Brand Awareness, and Word of Mouth on Purchase Decisions
Authors: Andrianti Berlina , Oetardjo Mas
Published: January 2023

This study aims to determine the effect of Digital Marketing, Brand Awareness, and Word Of Mouth on Purchase Decisions. This study uses a quantitative approach. Sampling in the study used accidental sampling technique, with the number of respondents as many as 95 respondents from Bund's Pizza consumers. Data collection techniques using questionnaires distributed through questionnaires. The data analysis technique in this study used multiple linear regression analysis. Data processing in this study used the software program SPSS 22 (Statistical Program For the Social Sciences). The results show that: Digital Marketing affects the Purchase Decision on Bund's Pizza Products, Brand Awareness affects the Purchase Decision on Bund's Pizza Products, and Word Of Mouth affects the Purchase Decision on Bund's Pizza Products.
The Effect of Taxpayer Knowledge, Taxpayer Awareness, and Service Quality on Motor Vehicle Taxpayer Compliance in Sidoarjo Regency During the Covid-19 Pandemic
Authors: Wulansari Ema Dwi , Dewi Santi Rahma
Published: January 2023

This study aims to determine Taxpayer Knowledge, Taxpayer Awareness and Service Quality Against Motor Vehicle Taxpayer Compliance in Sidoarjo Regency during the Covid-19 Pandemic. This study uses primary data, namely questionnaires distributed to 50 respondents using random sampling technique as a sampling technique. The population of this study were residents of the Jabaran village of Kapas Melati Hamlet who used motorized vehicles. The data analysis technique used is descriptive statistical analysis, validity test, reliability test, multiple linear regression test, coefficient of determination test and t test using SPSS. v.25 in data processing. The results of this study indicate that during the Covid-19 pandemic in Sidoarjo Regency, taxpayer knowledge has a significant effect on motor vehicle taxpayer compliance, taxpayer awareness has a significant effect on motor vehicle taxpayer compliance, and service quality has a significant effect on motor vehicle taxpayer compliance.
The Effect of Motivation, Job Satisfaction, Organizational Culture and Work Environment on Organizational Commitment to Employees
Authors: Heriyanto Muhammad Ferdiawan , Rizal Asat
Published: January 2023

This study aims to determine the effect of motivation, job satisfaction, organizational culture, and work environment on organizational commitment to employees of PT. Jasa Marga Pandaan-Malang. This study uses quantitative methods. The type of research used is descriptive research. The population in this study were all employees of PT. Jasa Marga Pandaan-Malang, which has 96 employees. Sampling using the "saturated sample" technique resulted in 96 respondents. Data collection techniques used are questionnaires and interviews. The analytical technique used in this research is multiple linear regression using SPSS version 18 program. The results of this study indicate that the simultaneous test of motivation, job satisfaction, organizational culture, and work environment variables have an influence on organizational commitment of PT. Jasa Marga Pandaan-Malang. The variable that has the most significant effect on organizational commitment is the work environment variable. Keywords – Motivation; Job satisfaction; Organizational culture; Work environment; Organizational Commitment
Regulatory Compliance for Protecting Land Plot Buyers in Sidoarjo: Implications for Legal Action and Buyer Protection
Authors: Condro Rudy , Multazam M Tanzil
Published: January 2023

This study employs a normative approach to investigate the legal protection for buyers of land plots located in Sidoarjo under Regulation number 59 of 2018. The deductive approach is utilized to prove the truth of the statement that protection for the sale and purchase of land plots can be canceled if not in compliance with the Sidoarjo regulation. The findings reveal that buyers of the land plot can seek legal protection if there are any discrepancies with the regulation. The study concludes that buyers of land plots in Sidoarjo can claim their rights and protection under the Regent's Regulation if there are any issues during the buying and selling process. The study also emphasizes the need to adhere to the regulations to ensure the protection of buyers of land plots.

Highlights:

The study employs a normative approach to investigate legal protection for buyers of land plots in Sidoarjo under Regulation number 59 of 2018.

Buyers can seek legal protection if there are any discrepancies with the regulation during the buying and selling process.

Adhering to the regulations is crucial to ensure the protection of buyers of land plots in Sidoarjo.
The Influence of Good Corporate Governance, Earning Power and Leverage on Earnings Management in Manufacturing Companies in the Industrial and Consumer Goods Sector
Authors: Firman Karinda , Widodo Heri
Published: January 2023

Earnings management becomes a special day for organizations because there are often conflicts of interest called information asymmetry. The purpose of this research is to know whether the variables of GCG, earning power and leverage have an influence on the earnings management variable. The population in this research is the industrial sector companies and manufactured consumer goods on the IDX in 2017 to 2019. Purposive sampling is a sampling technique taken to determine the sample in this research so that this study found a sample of 15 companies so that the total samples taken for 3 years from 15 companies are 45 companies then secondary data which is the source of data in this study is tabulated and processed with the help of SPSS version 25 then a set of test tools to support the hypothesis with a partial t-test. This is done is the size of the Board of Commissioners which is a proxy for GCG proven to be able to influence earnings management. Managerial ownership which is a proxy for GCG is proven to be able to influence earnings management. Institutional ownership which is a proxy for GCG is able to influence earnings management. The size of the Audit Committee, which is a proxy for GCG, is proven to be able to influence earnings management. Earning Power is proven to be able to influence earnings management. Leverage is proven to be able to influence earnings management.
The Effect of Career Development, Organizational Commitment, and Work Motivation on Employee Performance
Authors: Setiawan Andika Agus , Adji Kumara
Published: January 2023

This study aims to determine the effect of career development, organizational commitment and work motivation employee performance at CV. Farmer's Bracelet. This research uses quantitative methods. Sources of data used through primary data and secondary data. The data collection technique used a questionnaire which was distributed through a questionnaire. The sampling technique in this study is probability sampling technique and simple random sampling using the slovin formula for employees of CV. Bracelet Tani, with a total of 159 respondents. The results showed that: (1) Career Development (X1), Organizational Commitment (X2), and Work Motivation (X3) simultaneously affect Employee Performance (Y) on CV. Bracelet Tani. This conclusion is based on the results of the F test which shows Fcount t table and the significance value is less than 0.05 so that the first hypothesis proposed is proven true. (2) Career Development (X1), Organizational Commitment (X2), and Work Motivation (X3) partially affect Employee Performance (Y) on CV. Farmer's Bracelet. This conclusion is based on the results of the t test which shows that tcount ttable and the significance value is less than 0.05 so that the second hypothesis proposed is proven true. (3) Career Development (X1) is a variable that has a dominant influence on Employee Performance (Y) on CV. Farmer's Bracelet. This conclusion is based on the value of tcount and the value of standardized of coefficients Beta is the largest compared to the variables of Organizational Commitment (X2) and Work Motivation (X3). Keywords: Career Development; Organizational Commitment; Work motivation; Employee performance
The Influence of Service Quality and the Samsat Drive Thru System on Motor Vehicle Taxpayer Compliance with Tax Sanctions as Moderating Variables in Sidoarjo during the Covid-19 Pandemic
Authors: Putri Selly Novindia , Dewi Santi Rahma
Published: January 2023

This study aims to determine the effect of service quality and the drive thru samsat system on motor vehicle taxpayer compliance, whether tax sanctions are able to moderate service quality and the drive thru samsat system on motor vehicle taxpayer compliance. This research method uses quantitative, data collection is done by distributing questionnaires. The population in this study were students of the 2018 accounting study program. The sampling technique used in this study was using the slovin formula as many as 155 respondents. The data analysis technique used is the PLS-SEM analysis technique with the SmartPLS V.3 program. The results of the study show that service quality has no significant effect on motor vehicle taxpayer compliance, the drive thru system has a significant effect on motor vehicle taxpayer compliance, tax sanctions are not able to moderate service quality on motor vehicle taxpayer compliance, tax sanctions are able to moderate the Samsat drive system. thru on motor vehicle tax compliance.
The Effect of Work Environment, Organizational Culture, and Leadership Style Against the Spirit of the Work
Authors: Rifai Mohammad , Indayani Lilik
Published: January 2023

This thesis is not published. Management Studies Program. Faculty of Law, Business and Social Sciences, University of Muhammadiyah Sidoarjo. This study aims to determine the influence of the work environment, organizational culture and leadership style on morale at CV. Perpetual Association in Surabaya. The analytical tool used is tabulating the questionnaire, collecting data in the form of validity and reliability tests. The hypothesis in this study is that there is an influence of the work environment, organizational culture and leadership style on work morale. To test this hypothesis used data analysis tools in the form of multiple linear regression. The results of the simultaneous test showed that the work environment, organizational culture and leadership style had a simultaneous influence on work morale and the partial test showed that the work environment, organizational culture and leadership style had a partial effect on CV. Perpetual Association and Leadership Styles show the most significant influence.
The Effect of Service Quality, Brand Image, and Trust on Consumer Satisfaction on Delivery Services in Sidoarjo Regency
Authors: Permatasari Lina , Indayani Lilik
Published: January 2023

This study aims to determine the effect of service quality, brand image, and trust on consumer satisfaction at the J&T Express delivery service in Sidoarjo. In this study was conducted with quantitative methods. sampling using probability sampling technique with simple random sampling methods, with the number of samplesused in this study as many as 100 respondents from consumers J&T Express Sidoarjo. in this study used a questionnaire for data collection techniques. the data analysis techniquesused is multiple linier regression with the SPSS 22 (Statistical Package for the Social Sciences).The results in this study based on the t-test showed that service quality partially affected consumer satisfaction, brand image partially affected consumer satisfaction, and trust partially affected consumer satisfaction at the J&T Express delivery service in Sidoarjo. based on the f test, it showsthat service quality, brand image, and trust simultaneously affect customer satisfaction at the J&T Express delivery service in Sidoarjo
Consumer Perceptions About Online Service Quality
Authors: Putri Lusiana Indah Setyo , Sinduwiatmo Kukuh
Published: January 2023

This study aims to determine how consumers perceive the quality of service provided by CV Momentum Bertumbuh Indonesia as a company engaged in online guidance services. For a company to pay attention to the quality of good service to consumers is important so that consumers feel satisfied, have a good perception and foster loyalty. The research uses a qualitative method with a case study approach. Collecting data through interviews, observations and documentation with purposive sampling informant determination technique. Indicators to measure service quality are tangible, reliability, responsiveness, assurance, and empathy. The results of this study indicate that the company has a positive perception because it provides facilities according to what consumers expect and is responsive to providing services according to company procedures. There is a guaranteed fee provided and the mentoring process runs smoothly. However, there is a negative perception because some customer service in providing services is not timely and the company needs to provide facilities that can be accessed offline
The Effect of Workload Rewards and Organizational Commitment on Employee Performance Through Job Satisfaction as an Intervening Variable
Authors: Cahyati Inneke , Sumartik
Published: January 2023

This study aims to determine the effect of reward (X1), workload (X2), and organizational commitment (X3) on employee performance (Y) through job satisfaction as an intervening variable (Z). This research has a causal concept with the aim of obtaining truth results whether proven or not through the formulated hypothesis and using data analysis.  The analytical tool used in this research is path analysis technique with the help of SPSS (Statistical Package for the social science) version 25 for windows. The primary data in this study were obtained from a questionnaire whose measurement was using a Likert scale which was tested using validity and reliability tests. The results of this study show that (1) reward has a positive and significant effect on job satisfaction, (2) workload has a positive and significant effect on job satisfaction, (3) organizational commitment has a positive and significant effect on job satisfaction, (4) rewards have a positive effect and significant to employee performance, (5) workload has a positive and significant effect on employee performance, (6) organizational commitment has a positive and significant effect on employee performance, (7) job satisfaction has a positive and significant effect on employee performance, (8) reward has an effect positive and significant impact on employee performance through job satisfaction as an intervening variable, (9) workload has a positive and significant effect on employee performance through job satisfaction as an intervening variable, (10) organizational commitment has a positive and significant effect on employee performance through job satisfaction as an intervening variable.
The Effect of Work Stress Motivation and Organizational Culture on Employee Performance Through Job Satisfaction as an Intervening Variable
Authors: Satriyo Wibowo Nur Bahtiar , Sumartik
Published: January 2023

This study aims to determine the effect of work stress (X1), motivation (X2), and organizational culture (X3) on employee performance (Y) through job satisfaction as an intervening variable (Z). This research has a causal concept with the aim of obtaining truth results whether proven or not. The analytical tool used in this research is path analysis technique with the help of SPSS (Statistical Package for the social science) version 25 for windows. The primary data in this study were obtained from a questionnaire whose measurement was using a Likert scale which was tested using validity and reliability tests. The results of this study show that (1) job stress has a positive and significant effect on job satisfaction, (2) motivation has a positive and significant effect on job satisfaction, (3) organizational culture has a positive and significant effect on job satisfaction, (4) work stress has a positive and significant effect on job satisfaction. positive and significant effect on employee performance, (5) motivation has a positive and significant effect on employee performance, (6) organizational culture has a positive and significant effect on employee performance, (7) job satisfaction has a positive and significant effect on employee performance, (8) work stress positive and significant effect on employee performance through job satisfaction as an intervening variable, (9) motivation has a positive and significant effect on employee performance through job satisfaction as an intervening variable, (10) organizational culture has a positive and significant effect on employee performance through job satisfaction as an intervening variable.
The Influence of Regional Budget Management Capability on Organizational Performance With Internal Control Systems as Moderating Variables
Authors: Violina Merlin Sintia , Rachmawati Imelda Dian
Published: January 2023

This study aims to see whether the internal control system variabel is able to moderate the ability of budget management on organizational performance. The population used were several employees of the Sidoarjo transportation service office who understood the management of the budget and who carried out or made work plans for the Sidoarjo transportation service whit a total of 50 respondens. The sampling technique used the slovin formula by distributing questionnaires through manuals, namely using paper and distributing them to those concerned so that they got 44 respondens. The data analysis technique used the outer model and inner model and SmartPLS version 3.0 as a tool. Based on the results of this study proves that the ability to manage budget is able to significantly influence organizational performance. In moderation, the internal control system is abel to strengthen the variabel of budget management capability. As a result, it can be concluded that there is quasi-moderation, which means that the variabel that strengthens the correlation of the dependent variabel with the independent variabel and at the same time becomes the independent variable.
Sharing Knowledge of Roles in Mediating The Influence of Organizational Culture, Organizational Climate on Productive Behavior at Hospital
Authors: Fajriati Rahma , Abadiyah Rifdah
Published: January 2023

This study aims to determine the effect of competence, leadership style, and work discipline on employee motivation at PT. Mapan Putra Sentosa Sidoarjo. The population used in this study are employees of PT. Mapan Putra Sentosa Sidoarjo, totaling 55 people. By using the sampling technique Quota Sampling, where in this technique the emphasis is on taking samples based on the total population. This research was conducted with quantitative methods. The data collection technique used is a questionnaire. The data analysis technique used in this research is multiple linear regression using SPSS version 22 for windows. The results of this study indicate that, Competence does not have a partially significant effect on employee work motivation, leadership style has a partially significant effect on employee work motivation, work discipline has a partially significant effect on employee work motivation. Competence, Leadership Style, and Work Discipline have a simultaneous effect on employees' work motivation. Leadership style is the most significant variable on employee motivation.
Analysis Job Satisfaction with Leader Member Exchange and Organizational Climate Through Organization Citizenship Behavior in Company
Authors: Muarofah Siti , Abadiyah Rifda
Published: January 2023

This study aims to determine and analyze the influence of leader member exchange and organizational climate through organization citizenship behavior on job satisfaction of PT. Pabrik Gula Candi Baru.The research uses a quantitative approach. The sample in this study is the entire staff of PT. Candi Baru Sugar Factory with 34 employees. The analysis technique in this study uses path analysis, with t test and F test as research hypothesis testing. The results showed that: 1) Leader member exchange proved to have a significant effect on job satisfaction, 2) Organizational climate proved to have a significant effect on job satisfaction, 3) Leader member exchange proved to have a significant effect on job satisfaction through organizational citizenship behavior, 4) Organizational climate proved to have an effect. significant effect on job satisfaction through organization citizenship behavior, 5) Organization citizenship behavior has been proven to have a significant effect on job satisfaction for employees of PT. Pabrik Gula Candi Baru.
The Effect of Trust and Teamwork on Employee Performance Through Organizational Commitment as an Intervening Variable in Company
Authors: Aziz Abdul , Abadiyah Rifdah
Published: January 2023

This study aims to determine the effect of trust and teamwork on employee performance through organizational commitment as an intervening variable on CV. Bhagaskara Sinarmulya. The approach used in this research is a quantitative approach. The population in this study were 43 employees. The sampling technique used by the researcher is non-probability sampling with sampling using a saturated sampling technique, with a sample of 43 employees. Analysis using SmartPLS 3.0. The results obtained that teamwork affects employee performance, trust does not affect organizational commitment, teamwork affects organizational commitment, trust has no effect on employee performance through organizational commitment as an Intervening variable, and teamwork has an effect on employee performance through organizational commitment as an Intervening variable
Diseño de un sistema de costos de producción para la fuente de soda Jehova Jhire, distrito de Ate (Lima)
Authors:   , Alvaro Carbajal Sara Shakira , Cordova Vasquez William Alejandro , Delgado Diaz Rosa Elvira , Mandujano Lobo Jackelin , Meza Meza Heydi Jaritza
Published: January 2023

El presente trabajo de investigación tiene por objetivo implementar un sistema de costos para la empresa “Fuente de Soda Jehova Jhire E.I.R.L”, así como también ver el procedimiento que se tiene para la determinación de precios, por ende, este trabajo tiene una población de 25 productos de los cuales se escogieron por conveniencia 4 de ellos; se desarrolló el sistema de costo estándar como mejor opción, el cual se adapta de acuerdo a la actividad de la empresa. Por ello hemos logrado determinar las cantidades exactas de medidas que se deben utilizar para la fabricación de cada uno de los productos, asimismo se especificó las cantidades de las compras de los insumos a utilizar, por consiguiente, con los datos anteriores se logró especificar el costo unitario que se invertirá teniendo en cuenta la materia prima, mano de obra y el costo indirecto de fabricación, esta información nos ayudó a calcular el estado de resultados, el cual refleja una utilidad con el sistema y sin el sistema, mostrando una variación del 9% en la empresa.
Diferencia de las habilidades sociales de jóvenes jugadores de Dota 2 de nivel básico, intermedio y avanzado de la ciudad de Lima Metropolitana
Authors:   , Diaz Salgado Carlo Rafael
Published: January 2023

El objetivo del trabajo fue la de comparar, por medio del método de un estudio descriptivo comparativo, las diferencias en las habilidades sociales de los jugadores de Dota 2 según el nivel del juego; básico, intermedio y avanzado. La investigación utilizó la escala de habilidades sociales de Arnold P. Goldstein, adaptada por Ambrosio (1995). Llegaron a participar en la investigación 92 jugadores, de los cuales 91 fueron hombres y una mujer. En relación a los niveles de los jugadores 27 eran de nivel básico, 46 de nivel intermedio y 19 de nivel avanzado, por ocupación 10 fueron NINI, 56 estudiantes y 26 asalariados. Los resultados conseguidos con las encuestas y el análisis estadístico revelan niveles de habilidades sociales semejantes entre los diferentes niveles de desempeño de los jugadores, además se observa que del total de jugadores un 20% obtuvo un resultado Deficiente; 19% obtuvo un resultado Bajo Nivel; 23% un resultado Normal; 16% obtuvo un resultado Buen Nivel y por último 19% Excelente Nivel; viendo a un 58% con habilidades sociales adecuadas. De la misma manera, se evaluaron todas las dimensiones de la escala obteniendo puntajes promedios en relación a la prueba adaptada de Ambrosio.
Aislamiento social voluntario por Covid 19 y su relación en el estado emocional en los trabajadores del Hospital Nacional Edgardo Rebagliati Martins, 2021
Authors:   , Maldonado Toribio Ofelia Brenda , Torreblanca Chavez Jessica Rita
Published: January 2023

La pandemia originada por el coronavirus covid-19, cambio drásticamente la vida de los pobladores desde las actividades domésticas hasta las acciones laborales en todos los tipos de trabajo y estratos socioeconómicos. El área de salud no fue ajena a esta nueva normalidad e implantó medidas dictadas por el estado peruano que indicaban que el personal de salud en riesgo debía permanecer en aislamiento social voluntario, sin embargo, era necesario conocer la relación de esta medida con el estado emocional de los colaboradores de un centro hospitalario, por ello la investigación estuvo dirigida a verificar la relación de las variables propuestas, desarrollando una investigación de diseño no experimental, alcance descriptivo correlacional, con una muestra representativa de 325 trabajadores. La recogida de datos se desarrolló por encuesta online. Para la hipótesis general la correlación hallada fue de (r=0,568) indicando que la relación es moderada (Bisquerra 2014), concluyendo que el Aislamiento Social se relaciona significativamente con el Estado Emocional de los trabajadores del Hospital Nacional Edgardo Rebagliati Martins.
A novel controller algorithm to improve stability of power system based on hybrid of Fuzzy controller and Gray wolf optimization by coordinating PSS and TCSC with considering uncertainty
Authors: Abedini Mohamad
Published: January 2023

In this paper, a control scheme which combined the fuzzy controller and the optimal linear-quadratic regulator (LQR) controller is presented to increase the stability of the power system under different disturbance conditions. In addition, an optimization algorithm called Gray Wolf Optimizer (GWO) was also used to adjust the limits of fuzzy functions in order to response to possible variations applied on the system. Power system controllers including power system stabilizer (PSS) and thyristor controlled series capacitor (TCSC) were used simultaneously, and the controller coefficients as well as weighting matrices were also designed, optimally. Seven different scenarios related to the system under study were considered to show the controller's performance. The simulation results show that proposed Fuzzy-GWO controller having a proper operation and also having lower values of settling time and overshoot in comprising with other tradition controller methods.
A shuffled frog leaping-based hyper heuristic algorithm for material feeding scheduling optimization in an automatic monorail shuttle system
Authors: Zhou Binghai , Zhao Lingwei
Published: January 2023

In recent years, mixed-model assembly lines (MMALs) have been widely adopted by the automotive enterprises to face the requirements of mass customization. Meanwhile, the diversified components of various end products are placing the material feeding processes at great challenges. Under this circumstance, to raise the material feeding efficiency, this paper proposes an automatic monorail shuttle system (AMSS) based on line-integrated supermarkets applied to the MMALs by introducing the load-exchangeable shuttles and crossovers. Considering the importance of cost-control in manufacturing enterprises, we establish a mathematical model with the objective to minimize the total costs of the material feeding system, which includes the installation costs of crossovers and the input and operation costs of load-exchangeable shuttles. Then, due to the NP-hard nature of the proposed problem, a shuffled frog leaping-based hyper heuristic (SBHH) algorithm is developed to determine the allocation and scheduling of the shuttles and crossovers, which adopts the shuffled frog leaping algorithm (SFLA) as the high-level heuristic to select the low-level heuristics. To improve the performance of the algorithm, the concept of ‘dynamic decision unit’ is presented to raise the solution accuracy and the convergence speed. Finally, the simulation results verified the superiority of the proposed SBHH algorithm both in solution quality and convergence speed by comparing with other optimization algorithm in the existing literature.
An adaptive approach for preserving privacy in context aware applications for smartphones in cloud computing platform
Authors: Gadiyar H. Manoj T. , G.S Thyagaraju , Goudar R H
Published: January 2023

With the widespread use of mobile phones and smartphone applications, protecting one’s privacy has become a major concern. Because active defensive strategies and temporal connections between situations relevant to users are not taken into account, present privacy preservation systems for cell phones are often ineffective. This work defines secrecy maintenance issues similar to optimizing tasks, thereby verifying their accuracy and optimization capabilities through a hypothetical study. Many optimal issues arise while preserving one’s privacy and these optimal issues are to be addressed as linear programming issues. By addressing linear programming issues, an effective context-aware privacy-preserving algorithm (CAPP) was created that uses an active defence strategy to determine how to release a user’s current context to enhance the quality of service (QoS) regarding context-aware applications while maintaining secrecy. CAPP outperforms other standard methodologies in lengthy simulations of actual data. Additionally, the minimax learning algorithm (MLA) optimizes the policy users and improves the satisfaction threshold of the context-aware applications. Moreover, a cloud-based approach is introduced in our work to protect the user’s privacy from third parties. The obtained performance measures are compared with existing approaches in terms of privacy policy breaches, context sensitivity, satisfaction threshold, adversary power, and convergence speed for online and offline attacks.
Enhanced recovery after laparoscopic cholecystectomy: A single-center experience
Authors: Li Ming-zhe , Xin Chen , Wang Chen , Shi-zeng Li , Xia Bin , Wu Wen-hui , Zhang Chang-hua , He Yu-long
Published: January 2023

Background: The role of Eintraoperative joint organ removal or transit abdominal surgery recovery after surgery (ERAS) in reducing hospital stay time and perioperative hospitalization costs have been proven. However, most studies have been carried out in areas rich in medical resources. In this study, we evaluated the safety and efficacy of ERAS compared with traditional perioperative period care for laparoscopic cholecystectomy (LC) in areas poor in medical resources in China.
Methods: A randomized controlled trial on laparoscopic cholecystectomy was conducted at The People's Hospital of Fengqing from July 2020 to March 2021. Patients were randomly divided into an ERAS group and a traditional care group. The main outcome was the length of hospital stay after surgery. The secondary outcomes included hospitalization costs and visual analogue scale (VAS) scores for postoperative pain, first exhaust time, and first semi-liquid diet time after surgery. The ERAS group was provided with perioperative education, nutritional support, preoperative 2 h oral carbohydrates, restricted rehydration, intraoperative insulation, no drainage tubes, wound hemp, early mobilization postoperative nausea and vomiting (PONV) prevention and multi-modal analgesia, early activity.
Results: The study was conducted on a total of 140 patients with 70 patients each in the ERAS group and traditional care groups. In the ERAS group, The length of hospital stay after surgery was shorter (4.06 vs.4.61 days, P<0.05), the average hospitalization cost (CNY 7900 vs. 8470, P<0.05),and VAS score (3.10 vs. 3.57 points, compared to the eraser group P<0.001) was lower, the first exhaust time was shorter (12.2 vs. 14.2 hours, P<0.001), the first semi-liquid diet time after surgery was shorter(14.5 vs. 16.8 hours, P<0.001), and the incidence of major postoperative complications was lower (bile leakage, postoperative bleeding, bile duct damage) (0% vs. 12.9%, P<0.05). No significant difference in surgery time (57.8 vs. 54.6 min, P>0.05) was observed between the two groups.
Conclusion:Even in areas poor in medical resources in China, the use of the ERAS concept for LC surgery can reduce the length of hospital stay, cut down the cost of hospitalization, and lessen the pain of patients after surgery and accelerate postoperative recovery.
The Relationship between Long-term use of Nonsteroidal Anti-inflammatory Drugs and Kidney Function in Patients with Ankylosing Spondylitis
Authors: Koo Bon San , Hwang Subin , Park Seo Young , Shin Ji Hui , Kim Tae-Hwan
Published: January 2023

Background
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for ankylosing spondylitis (AS), their effect on kidney function remains unclear. This longitudinal study investigated the correlation between long-term NSAID use and kidney function in patients with AS using electronic medical records.
Methods
The electronic medical records of 1,280 patients with AS collected from a single center between January 2001 and December 2018 were reviewed. The Assessment of Spondyloarthritis International Society (ASAS) NSAID Intake Score was used to determine the cumulative dose of all NSAIDs prescribed for a different time intervals. Each ASAS NSAID Intake Score was obtained for intervals of 6 months, 1 year, 2 years, 3 years, 5 years, and 10 years. The correlation between the ASAS NSAID Intake Score and final estimated glomerular filtration rate (eGFR) for each interval was investigated.
Results
The mean ASAS Intake Scores for 6-month, 1-year, 2-year, 3-year, 5-year, and 10-year intervals were 55.30, 49.28, 44.84, 44.14, 44.61, and 41.17, respectively. At each interval, the pearson correlation coefficients were − 0.018 (95% CI: -0.031 ‒ -0.006, p = 0.004), -0.021 (95% CI: -0.039 ‒ -0.004, p = 0.018), -0.045 (95% CI: -0.071 ‒ -0.019, p = 0.001), -0.069 (95% CI: -0.102 ‒ -0.037, p < 0.001), -0.070 (95% CI: -0.114 ‒ -0.026, p = 0.002), -0.019 (95% CI: -0.099 ‒ 0.062, p = 0.645), respectively. There was a very weak negative relationship between ASAS Intake Score and eGFR at each interval.
Conclusion
Long-term NSAID use did not correlate with kidney function based on real-world data in patients with AS.
Post-fast refeeding enhances intestinal stem cell-mediated regeneration and tumourigenesis through mTORC1-dependent polyamine synthesis
Authors: Imada Shinya , Shin Heaji , Khawaled Saleh , Meckelmann Sven , Whittaker Charles , Correa Renan , Pradhan Dikshant , Calibasi Gizem , Nascentes Luiza Nascentes , Allies Gabriele , Wittenhofer Pia , Schmitz Oliver , Roper Jatin , Vinolo Marco , Cheng Chia-Wei , Tasdogan Alpaslan , Yilmaz Ömer
Published: January 2023

For more than a century, fasting regimens have improved health, lifespan, and tissue regeneration in diverse organisms, including humans. However, how fasting and post-fast refeeding impact adult stem cells and tumour formation has yet to be explored in depth. Here, we demonstrate that post-fast refeeding increases intestinal stem cell (ISC) proliferation and tumour formation: Post-fast refeeding augments the regenerative capacity of Lgr5+ intestinal stem cells (ISCs), and loss of the tumour suppressor Apc in ISCs under post-fast refeeding leads to a higher tumour incidence in the small intestine and colon than in the fasted or ad libitum (AL) fed states. This demonstrates that post-fast refeeding is a distinct state. Mechanistically, we discovered that robust induction of mTORC1 in post-fast-refed ISCs increases protein synthesis via polyamine metabolism to drive these changes, as inhibition of mTORC1, polyamine metabolite production, or protein synthesis abrogates the regenerative or tumourigenic effects of post-fast refeeding. Thus, fast-refeeding cycles must be carefully considered when planning diet-based strategies for regeneration without increasing cancer risk, as post-fast refeeding leads to a burst not only in stem cell-driven regeneration but also in tumourigenicity.
Characterization of murine isogenic normal and NRF2-KO colon epithelial cells to explore the food contaminants toxicity and oxidative stress involvement.
Authors: Dupuy Jacques , Fouché Edwin , Noirot Céline , Martin Pierre , Buisson Charline , Guéraud Françoise , Pierre Fabrice , Héliès-Toussaint Cécile
Published: January 2023

Cell lines are a useful tool for cellular metabolism and xenobiotic toxicity studies, but for modeling biological effects of molecules on healthy cells or cancer promotion it appeared necessary to develop a cellular model in a normal genetic context without mutations inherent to carcinogenic transformations. Colon mucosa is currently the target of xenobiotics such as food contaminants or naturally produced biomolecules from digestion, compelling normal cells to deal with toxic effects that can lead to genotoxicity and carcinogenic transformations. The toxicological properties of such compounds may rely on reactive oxygen species generation (ROS) which causes oxidative stress. One of the major regulators of ROS metabolism and antioxidant cellular defense is the transcription factor Nrf2. We developed a dual-cell model comparing normal murine epithelial cells with their Nrf2-KO isogenic cells generated through the CRISPR /Cas9 technique. HNE (4-hydroxy-2-nonenal), a lipid peroxidation product resulting from red meat digestion, inducing oxidative stress was used as a model molecule to evaluate normal epithelial cell response to food contaminant toxicity, and the importance of Nrf2 in the cellular protection against ROS injury. Implications of glutathione levels, gene regulation, viability, cell proliferation, and genotoxicity are discussed.
A spatial map of human macrophage niches reveals context-dependent macrophage functions in colon and breast cancer.
Authors: Matusiak Magdalena , Hickey John , Luca Bogdan , Lu Guolan , Kidzinski Lukasz , Zhu Shirley , Colburg Deana , Phillips Darci , Brubaker Sky , Charville Gregory , Shen Jeanne , Nolan Garry , Newman Aaron , West Robert , de Rijn Matt van
Published: January 2023

Tumor-associated macrophages (TAMs) display heterogeneous phenotypes. Yet the exact tissue cues that shape macrophage functional diversity are incompletely understood. Here we discriminate, spatially resolve and reveal the function of five distinct macrophage niches within malignant and benign breast and colon tissue. We found that SPP1 TAMs reside in hypoxic and necrotic tumor regions, and a novel subset of FOLR2 tissue-resident macrophages (TRMs) supports the plasma cell tissue niche. We discover that IL4I1 macrophages populate niches with high cell turnover where they phagocytose dying cells. Significantly, IL4I1 TAMs abundance correlates with anti-PD1 treatment response in breast cancer.
Furthermore, NLRP3 inflammasome activation in NLRP3 TAMs correlates with neutrophil infiltration in the tumors and is associated with poor outcome in breast cancer patients. This suggests the NLRP3 inflammasome as a novel cancer immunotherapy target. Our work uncovers context-dependent roles of macrophage subsets and suggests novel predictive markers and macrophage subset-specific therapy targets.
Detection of Congestion Free Route via Priority Federated Learning with Multi head Convolutional Neural Network
Authors: Devi M. Ramya , Jeya I. Jasmine Selvakumari , Lokesh S.
Published: January 2023

Owing to a rise in the number of vehicles on route, traffic has been increased dramatically in recent years. It has been noted that driving certain vehicles manually has become a challenging task. The challenges faced during an accident are the congestion of vehicles which blocks the ambulances during emergencies. Currently, traffic congestion is posing a major challenge for the public transportation system. To overcome these issues, a Priority federated learning with Multi-head CNN (PFL-MHCN2) has been proposed. Smart sensors and cameras equipped with IoT capabilities were used to collect data for the proposed model. Using this technique, signals from one junction are transmitted to another junction and updated in the cloud. A congestion spot is identified based on the input characteristics that are contained in the cloud and sensor data that are received. Initially, pre-processing reduces noisy values and predicts missing values in the acquired data. After pre-processing, the data are transferred to the detection layer. The Detection layer detects congestion free route using Federated Multi-head CNN. The proposed model is evaluated based on parameters like accuracy, precision, specificity, F1 score, and Miss rate. The proposed PFL-MHCN2 model produces a 0.65% miss rate, which is less than existing methods. The proposed technique improves the accuracy of 1.45%, 1.66%, and 4.32% better than TCC-SVM, TC2S-DNN and MSR2C-ABPNN respectively.
Impact of the Covid-19 pandemic on inpatient health care in Switzerland – a retrospective study using admission data of all Swiss hospitals
Authors: Wirth Brigitte , Stucki Michael , Joerg Reto , Thommen Christoph , Höglinger Marc
Published: January 2023

Background: As part of the Covid-19-restrictions in Switzerland, a federal ban on non-urgent examinations and treatments was applied to all hospitals during six weeks in spring 2020 (“spring lockdown”). The aim of this study was to comprehensively investigate the consequences of the Covid-19 pandemic on Swiss inpatient admissions based on data of all hospitals, focusing on selected procedures of different medical urgency.
Methods: The study includes all acute care inpatient cases (including Covid-19 cases, excluding cases in psychiatry and rehabilitation) according to the Swiss Medical Statistics of Hospitals. Besides the total number of admissions, subdivided by regions, hospital types and age groups, we focused on selected procedures representing different medical urgency: elective surgeries, cancer surgeries, and emergencies. Procedures were selected based on expert interviews. We compared the number of admissions during spring lockdown and for the whole years 2020 and 2021 in absolute numbers and in percentage changes to the corresponding periods in 2019 (baseline year).
Results: During spring lockdown, the number of admissions decreased by 47,156 (32.2%) without catch-up effect by the end of 2020 (-72,817 admissions/-5.8%). With procedure-specific decreases of up to 86%, the decline in admissions was largest for elective surgery, a decline that was only fully reversed in the case of a few procedures, such as joint arthroplasty. Strikingly, admissions due to emergencies also substantially decreased during spring lockdown (stroke -14%; acute myocardial infarction STEMI: -9%, NSTEMI: -26%). Results for the selected procedures in cancer surgery showed no consistent pattern. In 2021, admission numbers for most procedures reached or even exceeded those in 2019.
Conclusions: The substantial reduction in admissions, particularly in elective procedures, may reflect the impact of the triage in favor of anticipated Covid-19-cases during spring lockdown. By the end of 2020, admissions were still at lower levels relative to the previous, pre-pandemic year. The numbers in 2021 reached the same levels as those in 2019, which suggests that the Covid-19 pandemic only temporarily impacted inpatient health care in Switzerland. Long-term consequences of the observed reduction in admissions for emergencies and cancer surgery need to be investigated at the individual level.