bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Acute Motor Effects and Tolerance Following Self‐Administration of Alcohol and Edible ∆9‐Tetrahydrocannabinol in Adolescent Male Mice
Authors: Smoker Michael P. , Hernandez Maribel , Zhang Yanping , Boehm Stephen L.
Published: September 2019

Background

Cannabinoids and their principle psychoactive target, the cannabinoid type 1 receptor (CB1R), impact a number of alcohol‐related properties, and although alcohol and cannabis are often co‐used, particularly in adolescence, few animal models of this phenomenon exist. We modeled the co‐use of alcohol and ∆9‐tetrahydrocannabinol (THC) in adolescent mice using ingestive methods popular during this developmental period in humans, namely binge‐drinking and edible THC. With this model, we assessed levels of use, acute effects, and tolerance to each substance.

Methods

Adolescent male C57BL/6J mice had daily, limited access to 1 of 2 edible doughs (THC or control), to 1 of 2 fluids (ethanol (EtOH) or water), and in 1 of 2 orders (dough–fluid or fluid–dough). Home cage locomotor activity was recorded both during access and after access. On the day following the final access session, a subset of mice were assessed for functional and metabolic tolerance to alcohol using accelerating rotarod and blood EtOH concentrations, respectively. The remaining mice were assessed for tolerance to THC‐induced hypothermia, and whole‐brain CB1R expression was assessed in all mice.

Results

EtOH intake was on par with levels previously reported in adolescent mice. Edible THC was well‐consumed, but consumption decreased at the highest dose provided. Locomotor activity increased following EtOH intake and decreased following edible THC consumption, and edible THC increased fluid intake in general. The use of alcohol produced neither functional nor metabolic tolerance to an alcohol challenge. However, the use of edible THC impaired subsequent drug‐free rotarod performance and was associated with a reduction in THC's hypothermic effect.

Conclusions

Adolescent mice self‐administered both alcohol and edible THC to a degree sufficient to acutely impact locomotor activity. However, only edible THC consumption had lasting effects during short‐term abstinence. Thus, this adolescent co‐use model could be used to explore sex differences in self‐administration and the impact substance co‐use might have on other domains such as mood and cognition.
Double missense mutations in cardiac myosin‐binding protein C and myopalladin genes: A case report with diffuse coronary disease, complete atrioventricular block, and progression to dilated cardiomyopathy
Authors: Mastroianno Sandra , Palumbo Pietro , Castellana Stefano , Leone Maria Pia , Massaro Raimondo , Potenza Domenico Rosario , Mazza Tommaso , Russo Aldo , Castori Marco , Carella Massimo , Di Stolfo Giuseppe
Published: September 2019

Cardiomyopathies caused by double gene mutations are rare but conferred a remarkably increased risk of end‐stage progression, arrhythmias, and poor outcome. Compound genetic mutations leading to complex phenotype in the setting of cardiomyopathies represent an important challenge in clinical practice, and genetic tests allow risk stratification and personalized clinical management of patients. We report a case of a 50‐year‐old woman with congestive heart failure characterized by dilated cardiomyopathy, diffuse coronary disease, complete atrioventricular block, and missense mutations in cardiac myosin‐binding protein C (MYBPC3) and myopalladin (MYPN). We discuss the plausible role of genetic profile in phenotype determination.
Extended persistence of antiphospholipid antibodies beyond the 12‐week time interval: Association with baseline antiphospholipid antibodies titres
Authors: Devignes Jean , Smaïl‐Tabbone Malika , Hervé Alex , Cagninacci Geoffroy , Devignes Marie‐Dominique , Lecompte Thomas , Zuily Stéphane , Wahl Denis
Published: September 2019

Introduction

The confirmation time interval for the presence of antiphospholipid antibodies (aPL) has been extended to 12 weeks as epiphenomenal antibodies may disappear after 6 weeks. Our aim was to analyse extended persistence of aPL positivity beyond the 12‐week interval.

Methods

We retrospectively analysed our database of 23 856 aPL test samples collected between 2005 and 2017 from 17 367 consecutive patients. Two groups of patients were identified among aPL‐positive patients, confirmed at 12 weeks: with or without extended persistence beyond confirmatory testing. Percentages of extended persistence are given according to the initial aPL positivity profiles, and baseline laboratory variables are compared between the two groups.

Results

Three hundred and twenty‐seven patients confirmed aPL‐positive had subsequent testing. The vast majority of them displayed extended persistence in the long term: 89.6% and up to 97.9% for patients with initial triple positivity. In extended persistent positive patients, there were more LA‐positive initial samples, and baseline LA test values and IgG aCL titres were higher than in nonpersistent positive patients.

Conclusion

Data from a large database of an aPL referral laboratory showed that the time interval of 12 weeks defining persistence of aPL positivity was appropriate for the majority of patients. Furthermore, we found baseline features associated with extended persistence.
Quality disclosure strategy in a decentralized supply chain with consumer returns
Authors: Feng Zhangwei , Xiao Tiaojun , Yu Yunlong , Robb David J.
Published: September 2019

We study the quality disclosure strategy of a manufacturer/retailer in a supply chain with consumer returns for new products. In particular, we explicitly model the effect of quality disclosure on the reduction of the returns rate. We identify the condition in which the manufacturer/retailer should reveal product quality in the presence of consumer returns. We find that (1) the manufacturer/retailer has an incentive to choose quality disclosure strategy when the disclosure quality is above a lower bound; (2) if the returns rate of new products is low, the retailer‐disclosure scenario leads to reveal more quality information than that of the manufacturer‐disclosure scenario; otherwise, the manufacturer‐disclosure scenario leads to reveal more quality information; and (3) the manufacturer prefers to reveal a higher level of product quality in the supply chain with a higher refund amount or a lower salvage value per unit of returned product.
Extraction and characterization of water‐soluble polysaccharides from Tamarindus indica and Pithecellobium dulce seeds
Authors: Sivakumar Nandhineeswari , Karuppaiyan Kavitha
Published: September 2019

Water‐soluble polysaccharides (WSP) were secluded from Tamarindus indica (TWSP) and Pithecellobium dulce (PWSP) seeds by hot water method. The physico‐chemical properties revealed that the polysaccharides might be used as a potential food additive. The micrometric properties of TWSP and PWSP possessed a bulk density of 0.64 and 0.68 g/ml, respectively. The isolated polysaccharides were subjected to Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopy for its compositional analysis and exhibited that both the isolates are heteropolysaccharides. The spectra of both the mucilages were resonating at δ 3.00–δ 5.00 ppm which confirmed the presence of polysaccharides. Thermo gravimetric analysis showed that the isolated polysaccharides were thermally stable. Scanning electron microscopy and X‐ray diffraction depicted the morphological characteristics. The radical scavenging ability and antibacterial activity proved that the polysaccharides can be explored as a functional food ingredient. Furthermore, the prebiotic potential of polysaccharides stimulated the growth of Lactobacillus delbrueckii and Lactobacillus fermentum over inulin.

Practical applications

The study provides optimum extraction conditions to obtain TWSP and PWSP seeds using response surface methodology. The isolated polysaccharides can be used as therapeutic agent and as a food additive due to its high purity obtained from Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopic analysis. The excellent flowability and compressibility of polysaccharides can be applied in pharmaceutical formulation as an excipient. The active component present in the isolated polysaccharides can be used as a food preservative. The supplement of TWSP and PWSP as a carbon source accelerated the growth of probiotics which could be used as natural prebiotics. Thus the study concluded that the water‐soluble polysaccharide obtained from the agro‐industrial by product has the wide application in food and pharmaceutical industries.
A cost–benefit analysis of the environmental taxation policy in China: A frontier analysis‐based environmentally extended input–output optimization method
Authors: Wang Ke , Wang Jiayu , Hubacek Klaus , Mi Zhifu , Wei Yi‐Ming
Published: September 2019

China's high‐speed economic development and reliance on overconsumption of natural resources have led to serious environmental pollution. Environmental taxation is seen as an effective economic tool to help mitigate air pollution. In order to assess the effects of different scenarios of environmental taxation policies, we propose a frontier‐based environmentally extended input–output optimization model with explicit emission abatement sectors to reflect the inputs and benefits of abatement. Frontier analysis ensures policy scenarios are assessed under the same technical efficiency benchmark, while input–output analysis depicts the wide range of economic transactions among sectors of an economy. Four scenarios are considered in this study, which are increasing specific tax rates of SO2, NOx, and soot and dust separately and increasing all three tax rates simultaneously. Our estimation results show that: raising tax rates of SO2, NOx, and soot and dust simultaneously would have the highest emission reduction effects, with the SO2 tax rate making the greatest contribution to emission reduction. Raising the soot and dust tax rate is the most environmentally friendly strategy due to its highest abatement to welfare through avoided health costs. The combination of frontier analysis and input–output analysis provides policy makers a comprehensive and sectoral approach to assess costs and benefits of environmental taxation.
Update on Research and Practices in Major Sleep Disorders: Part II—Insomnia, Willis‐Ekbom Disease (Restless Leg Syndrome), and Narcolepsy
Authors: Chaiard Jindarat , Weaver Terri E.
Published: September 2019

Purpose

This review (Part II of a series on sleep disorders) presents an update of the characteristics, epidemiology, assessment, and latest management of insomnia, restless legs syndrome (Willis‐Ekbom disease; RLS/WED), and narcolepsy. Insomnia, the most common sleep disorder and most prevalent of all psychological health disorders, is a problem of difficulty initiating and maintaining sleep and early morning awakenings. RLS/WED is characterized by a crawling sensation or urge to move the legs in the evening and nighttime. Narcolepsy is a sleep disorder that commonly results in chronic daytime sleepiness and cataplexy. Nonpharmacological management, which includes education, cognitive behavioral therapy, and complementary therapy, is used as primary or adjunctive to pharmacotherapy for the treatment of these disorders.

Methods

This narrative review utilized medical databases such as PubMed to identify relevant English‐language original and systematic review articles predominantly from peer‐reviewed journals from 2012 to 2019. However, as background, findings from classic articles prior to 2012 were also included.

Clinical Relevance

Assessment of sleep problems, excessive sleepiness, and difficulty performing activities or being productive should be routine in the care of all patients. Utilization of behavioral interventions, including cognitive behavioral therapy, in addition to education and sleep hygiene, can promote sleep quality. Management of insomnia, RLS/WED, and narcolepsy should include helping patients adjust to treatment, managing cataplexy triggers in narcolepsy, and initiating strategies to live with chronic illness to improve quality of life.
The effect of 1540‐nm fractional erbium‐glass laser in the treatment of androgenic alopecia
Authors: Alhattab Mohammed K. , AL Abdullah Mohammad J. , Al‐janabi Murtadha H. , Aljanaby Wejdan A. , Alwakeel Hadi A.
Published: September 2019

Background

Androgenic alopecia is common, chronic dermatologic disorder. A variety of lasers and light sources appear to be safe and effective in the treatment of AGA.

Aims

To evaluate the efficacy and safety of 1540‐nm fractional erbium glass laser in the treatment of AGA.

Patients/Methods

This was an interventional therapeutic study for the treatment of patients with AGA. The patients received 10 sessions with 1540‐nm fractional erbium glass laser at 2‐week intervals. The assessment of the response was done before and at the end of follow‐up period, both objectively (the change in the density of terminal hair and the diameter of the hair shaft) and subjectively (patient satisfaction). Any adverse effects were documented during the study.

Results

Forty‐seven out of 51 patients completed the study. After 5 months of laser treatment, the density of hair and hair thickness was significantly increased in both males and females (P value .001).

Conclusion

The 1540‐nm fractional erbium‐glass laser seems to be an effective and safe option for treatment of patients with AGA. The improvement was accomplished in a short period.
Infant with hypopigmented streaks
Authors: Venning Victoria L , Rajagopalan Sulekha , Sebaratnam Deshan F
Published: September 2019

See Answer
THE OLIGOCENE–MIOCENE MENILITE FORMATION IN THE UKRAINIAN CARPATHIANS: A WORLD‐CLASS SOURCE ROCK
Authors: Rauball J. F. , Sachsenhofer R. F. , Bechtel A. , Coric S. , Gratzer R.
Published: September 2019

This study investigates the hydrocarbon potential of Oligocene–Miocene shales in the Menilite Formation, the main source rock in the Ukrainian Carpathians. The study is based on the analysis of 233 samples collected from outcrops along the Chechva River in western Ukraine in order to analyse bulk parameters (TOC, Rock‐Eval), biomarkers and maceral composition.

In Ukraine, the Menilite Formation is conventionally divided into Lower (Lower Oligocene), Middle (Upper Oligocene) and Upper (Lower Miocene) Members. The Early Oligocene and Early Miocene ages of the lower and upper members are confirmed by new nannoplankton data. The Lower Menilite Member is approximately 330 m thick in the study area and contains numerous chert beds and turbidite sandstones in its lower part together with organic‐rich black shales. The shales have a high content of silica which was probably derived from siliceous micro‐organisms. The TOC content of the shales frequently exceeds 20 wt.% and averages 9.76 wt.%. HI values range between 600 and 300 mgHC/gTOC (max. 800 mgHC/gTOC). The Middle Member contains thin black shale intervals but was not studied in detail. The Upper Member is about 1300 m thick in the study area and is composed mainly of organic‐rich shales. Chert layers are present near the base of the Member, and a prominent tuff horizon in the upper part represents a volcanic phase during shale deposition. The member grades into overlying molasse sediments. The average TOC content of the Upper Menilite succession is 5.17 wt.% but exceeds 20 wt.% near its base.

Low Tmax and vitrinite reflectance measurements for the Lower (419°C and 0.24–0.34 %Rr, respectively) and Upper (425°C and 0.26–0.32 %Rr, respectively) Menilite Member successions indicate thermal immaturity. Biomarker and maceral data suggest a dominantly marine (Type II) organic matter input mixed with varying amounts of land‐plant derived material, and indicate varying redox and salinity conditions during deposition.

Determination of the Source Potential Index (SPI) shows that the Menilite Formation in the study area has the potential to generate up to 74.5 tons of hydrocarbons per m2. The Chechva River outcrops therefore appear to have a significantly higher generation potential than other source rocks in the Paratethys realm. These very high SPI values for the Menilite Formation may explain why a relatively small area in Ukraine hosts about 70% of the known hydrocarbon reserves in the northern and eastern Carpathian fold‐thrust belt.
Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat
Authors: Khoshnazar Mahdieh , Bigdeli Mohammad Reza , Parvardeh Siavash , Pouriran Ramin
Published: September 2019

Objectives

Oxidative stress and inflammation have a critical role in the pathogenesis of ischaemic stroke. Alpha-pinene is a monoterpenoid molecule with anti-inflammatory and antioxidant properties. The nobility of the present study was to evaluate the neuroprotective effect of α-pinene in ischaemic stroke.

Methods

Ischaemic stroke was induced by transient middle cerebral artery occlusion followed by 24 h reperfusion in male Wistar rats. Alpha-pinene (25, 50 and 100 mg/kg, i.p.) was administered in the beginning of reperfusion. Then, the neurobehavioural function, infarct volume, brain oedema, antioxidant enzyme activity and the concentration of malondialdehyde (MDA), nitric oxide (NO) and interleukin-6 (IL-6) were evaluated by different methods in the brain.

Key findings

Alpha-pinene (50 and 100 mg/kg) elicited a significant decrease in the brain oedema and infarct size as well as an improvement in the neurobehavioural function. Besides, α-pinene (100 mg/kg) restored the function of superoxide dismutase, catalase and glutathione peroxidase and reduced the concentration of MDA, NO and IL-6 in the hippocampus, cortex and striatum.

Conclusions

It was ultimately attainted that α-pinene exerts neuroprotective effect in ischaemic stroke in rat through the restoration of antioxidant enzymes activity, attenuation of lipid peroxidation and reduction of inflammation in the ischaemic brains.
Effect of Salinity on DMSP Production in Gambierdiscus belizeanus (Dinophyceae)
Authors: Gwinn Jessica K. , Robertson Alison , Kiene Ronald P.
Published: September 2019

Dimethylsulfoniopropionate (DMSP) is produced by many species of marine phytoplankton and has been reported to provide a variety of beneficial functions including osmoregulation. Dinoflagellates are recognized as major DMSP producers; however, accumulation has been shown to be highly variable in this group. We explored the effect of hyposaline transfer in Gambierdiscus belizeanus between ecologically relevant salinities (36 and 31) on DMSP accumulation, Chl a, cell growth, and cell volume, over 12 d. Our results showed that G. belizeanus maintained an intracellular DMSP content of 16.3 pmol cell−1 and concentration of 139 mM in both salinities. Although this intracellular concentration was near the median reported for other dinoflagellates, the cellular content achieved by G. belizeanus was the highest reported of any dinoflagellate thus far, owing mainly to its large size. DMSP levels were not significantly affected by salinity treatment but did change over time during the experiment. Salinity, however, did have a significant effect on the ratio of DMSP:Chl a, suggesting that salinity transfer of G. belizeanus induced a physiological response other than DMSP adjustment. A survey of DMSP content in a variety of Gambierdiscus species and strains revealed relatively high DMSP concentrations (1.0–16.4 pmol cell−1) as well as high intrageneric and intraspecific variation. We conclude that, although DMSP may not be involved in long‐term (3–12 d) osmoregulation in this species, G. belizeanus and other Gambierdiscus species may be important contributors to DMSP production in tropical benthic microalgal communities due to their large size and high cellular content.
Association between the neutrophil‐to‐lymphocyte ratio and intravesical prostatic protrusion in men with benign prostatic hyperplasia
Authors: Chung Mun Su , Yang Yun Jung , Lee Seung Hwan , Yoon Byung Il
Published: September 2019

Objective

To analyze the association between neutrophil‐to‐lymphocyte ratio (NLR) and intravesical prostatic protrusion (IPP) in men with benign prostatic hyperplasia.

Methods

Two hundred and fifty men aged >50 years who presented with lower urinary tract symptoms at our institution between 2014 and 2018 were analyzed. Pearson's method was used for analysis of the correlation between NLR and IPP. Multivariate logistic regression analysis was used to identify predictors of IPP. Further analysis according to total prostate volume (TPV) was performed.

Results

The NLR correlated positively with IPP (Pearson's r = 0.459, P < 0.001) and was an independent predictor of IPP ≥10 mm (odds ratio, 2.95; 95% confidence interval, 1.59–5.47; P = 0.0006). Among the 142 men with prostates <40 cm3, mean NLR was 2.50 ± 0.71 in those with IPP ≥10 mm and 1.71 ± 0.57 in those with IPP < 10 mm (P < 0.001). The NLR differed significantly between those with a prostate <40 cm3 and IPP ≥10 mm and those with a larger prostate and IPP < 10 mm (2.50 ± 0.71 vs 2.07 ± 0.77, respectively; P = 0.020).

Conclusions

NLR can be used as a surrogate marker for presence of IPP. Its clinical value would be especially important in men with a small prostate gland but high IPP. The NLR seemed to be more strongly correlated with IPP than with TPV.
Effects of sedentary behavior and physical activity on sleep quality in older people: A cross‐sectional study
Authors: Seol Jaehoon , Abe Takumi , Fujii Yuya , Joho Kaya , Okura Tomohiro
Published: September 2019

The aim of this cross‐sectional study was to investigate the influence of replacing sedentary time with time engaged in one of two levels of physical activity on sleep quality using an isotemporal substitution model. The participants were 70 community‐dwelling older Japanese adults (approximately 70% female). Physical activity types were measured using a triaxial accelerometer and categorized based on intensity as sedentary, light‐intensity, and vigorous‐intensity. The Pittsburgh Sleep Quality Index assessed subjective sleep quality. Objective sleep parameters were assessed using an actigraph. A series of multi‐linear regression models analyzed the statistical relationships. Our findings showed that replacing 30 min of sedentary activity per day with an equal period of light‐intensity physical activity significantly influenced sleep quality parameters. However, there was no significant difference in sleep quality when light‐intensity activity was replaced with vigorous‐intensity activity. Engaging in one activity type means less available time for other types of activity; habitual replacement of sedentary activity with light‐intensity physical activity might have long‐term benefits on the sleep quality of older people.
Aspiration predictors in Parkinson's disease: Is there a relation between disease severity, disease duration and age of onset?
Authors: Argolo Natalie , Nóbrega Ana Caline
Published: September 2019

Still exist many controversies about clinical predictors for aspiration in PD such as duration or severity of the disease. Later‐onset PD patients are associated with more dysphagia symptoms. Age of PD onset may modify the association of disease duration and severity with aspiration.
Basic Human Values and Their Contexts: A Multilevel Analysis of Support for the Use of Armed Drones in the United States, United Kingdom, and Turkey
Authors: O'Dwyer Emma , Ҫoymak Ahmet
Published: September 2019

Armed drones are now a key component of military strategy; however, little empirical research has explored the phenomenon in terms of psychological processes. Previous research has emphasized the importance of basic human values for structuring understandings of and opinions towards foreign policy issues. Using a social representations approach, we used a multilevel modeling approach to explore the link between values and support for the use of armed drones in the United Kingdom, the United States, and Turkey. In line with our predictions, high priority of self‐transcendence values negatively predicted, and high priority of conservation values positively predicted, support for armed drones. Furthermore, given our theoretical framework, we specified that values should be conceptualized as prioritized or devalued within a particular context, and when values were specified as country‐level, as well as individual predictors, this led to an increase in model fit. These findings are discussed in light of a developing line of research on meta‐representations and their consequences for political opinion, and directions for future research are advanced.
Phenotypic plasticity and morphological adaptation of Halimeda opuntia (Bryopsidales, Chlorophyta) to light intensity
Authors: Pongparadon Supattra , Nooek Sontaya , Prathep Anchana
Published: September 2019

Plasticity gives plants the ability to adapt their morphology and growth to various environments. Environmental factors can lead to changes in the growth forms of algae. Halimeda opuntia was used as a model organism to determine the effects of highly irradiated and shade conditions in the field and its responses to low light conditions in the laboratory, which are known to be some of the main factors driving its morphological plasticity. To investigate the morphological and anatomical characteristics of the species, a total of 61 characteristics and 54 samples from Thailand, Japan and Indonesia were examined. In addition, we also tested the response under different light conditions in the laboratory. A phylogenetic tree was constructed using the tufA marker to confirm the species identification. We found that the thallus forms, branching patterns and segment shapes and sizes responded to the different light conditions. A brittle thallus network was found under shade conditions with low light intensity, while a compact thallus form was found under highly irradiated conditions. The H. opuntia segment shape was reniform under highly irradiated conditions, but its segments were adapted to be deeply trilobed in the lower thallus and tripartite shape in the upper thallus under shade conditions. The segment size also adapted; the segments in shaded areas were longer than those in sunny areas, which might have helped them increase their thallus height to ensure exposure to the high light habitat. This morphological variation and plasticity expanded our understanding of the range of H. opuntia plasticity present in the field and could help explain why this species is common and successfully colonizes various habitats worldwide.
Bio‐priming seeds with cyanobacteria: effects on native plant growth and soil properties
Authors: Chua Melissa , Erickson Todd E. , Merritt David J. , Chilton Angela M. , Ooi Mark K. J. , Muñoz‐Rojas Miriam
Published: September 2019

Cyanobacteria are photosynthetic bacteria that form a fundamental part of soil biocrusts, enhance soil function and structure, and can promote plant growth. We assessed the potential of cyanobacteria as a seed bio‐primer for mine‐site restoration in an arid region in Western Australia, examining its effects on native plant growth and the characteristics of mine soil substrates used in dryland restoration. Cyanobacteria strains indigenous to the study region (Leptolyngbya sp., Microcoleus sp., Nostoc sp., and Scytonema sp.) were used to create an inoculant. Seeds of seven native plant species were bio‐primed with the inoculant, and their germination and growth assessed in a laboratory experiment. Seedling growth after bio‐priming was assessed in a glasshouse experiment for a subset of three species, in two different substrates (topsoil and mine waste). Soil properties related to soil function, e.g. total organic carbon, total nitrogen, and microbial activity, were also measured. Minor effects on germination were recorded with only significantly higher germination rates reported in E. gamophylla. Soil parameters were generally higher in topsoil than in mine waste, regardless of bio‐priming treatment. However, bio‐priming resulted in seedlings of four species producing longer radicles and/or shoots. For example, seedling root lengths of bio‐primed G. wickhamii were 57% larger than the control treatment (30.1 ± 4.3 and 13.0 ± 1.6 mm, respectively); and shoots of T. wiseana were 54% longer in the bio‐primed treatment (18.6 ± 1.6 mm) compared to the control (8.53 ± 1.4 mm). Overall, our results highlight that bio‐priming with cyanobacteria may improve plant growth for some species commonly used in dryland restoration.
Manufacturing growth accelerations in developing countries
Authors: Haraguchi Nobuya , Martorano Bruno , Sanfilippo Marco , Shingal Anirudh
Published: September 2019

This paper investigates the factors driving manufacturing growth accelerations in a sample of 134 developing countries over the period 1970 to 2014. We first identify growth acceleration episodes of manufacturing value added (MVA) by their year of initiation and according to a country’s income classification. We then estimate a probit model to explain what factors predict these MVA growth accelerations. Our results show that human capital and institutions represent contextual factors that favor the growth of manufacturing, together with macroeconomic policies related to investment, and openness to foreign trade and capital. We also find that most of these factors not only foster episodic accelerations of industry, but they contribute as well to a sustained process of industrialization that characterized the process of economic growth of a few successful countries over the period 1970 to 2014.
The metabolic mind: A role for leptin and ghrelin in affect and social cognition
Authors: MacCormack Jennifer K. , Muscatell Keely A.
Published: September 2019

Leptin and ghrelin are metabolic hormones central to energy regulation in the body. Theories of allostasis suggest that metabolism could matter for more than just food intake and weight regulation but also ultimately for psychological processes, such as affect and social cognition. Allostasis is the process by which the brain monitors ongoing physiological states and, in turn, regulates physiology based on expectations about how a given situation will impact the self. Motivated by this allostatic perspective, we argue that leptin and ghrelin may be influenced by and even contribute to psychological processes such as affect and social cognition. Specifically, we review literature suggesting that leptin and ghrelin may be sensitive to social affective signals and related contexts (e.g., social status, and social threat vs. support), given that these signals and contexts may represent access to tangible physical and psychological resources that support allostasis and metabolic needs. We then review literature showing that leptin, ghrelin, and associated metabolic states may feed into the construction of social affective states and behaviors (e.g., emotion and risk taking), in order to motivate behaviors in line with allostatic needs. We close by offering guidelines for researchers interested in contributing to this emerging field and highlight opportunities for future research. We believe that leptin and ghrelin offer exciting new directions for social and affective scientists interested in linking the mind, brain, and body.
Self‐regulation as relating to one's ideal possible self
Authors: Haskins LeeAnn B. , vanDellen Michelle R.
Published: September 2019

People dream of countless ideal possible selves they hope to become, but they have a difficult time actualizing them. In the present work, we review and integrate prior research regarding possible selves, self‐regulation, and interpersonal relationships. We draw on multiple perspectives to define ideal possible selves and clarify their structure. We suggest that framing self‐regulation of an ideal possible self as relating to one's ideal possible self affords an explanation that ideal possible selves can (but sometimes do not) motivate current self‐regulation. We discuss two ways ideal possible selves motivate current self‐regulatory behavior: through increased vividness of the ideal possible self and through commitment to the ideal possible self. These routes pave the way for future research designed to help people increase their efforts toward becoming their ideal possible selves.
HLA‐A*31:68, a novel variant of HLA‐A*31, discovered in a Taiwanese individual
Authors: Yang Kuo‐Liang , Lin Py‐Yu
Published: September 2019

Nucleotide replacements in codons 126 and 127 of HLA‐A*31:01:02:01 result in a novel allele, HLA‐A*31:68.
Identification of HLA‐A*24:02:78 by next‐generation sequencing in a Chinese Han individual
Authors: Gao Su‐Qing , Hong Wen‐Xu , Deng Zhi‐Hui , Quan Zhan‐Rou
Published: September 2019

HLA‐A*24:02:78 differs from HLA‐A*24:02:01:01 in exon 3 by a single nucleotide.
Effect of Handedness and Footedness on Some Motoric Characteristics in Amateur Soccer Players
Authors: Yüceloğlu Keskin Deniz Özge , İmamoğlu Osman , Kabadayı Menderes
Published: September 2019

The present study aims to compare the strength of right and left legs and reaction times of soccer players depending on their hand and foot preferences. The study included 92 volunteers chosen from amateur soccer players. The measurements conducted on the subjects were anthropometric characteristics, foot reaction times (sound, light) and right and left foot squat parameters. The t-test was used for statistical procedures. Among the amateur soccer players who participated in this study, it was found that 19.57% used left hand and 67.39% used right hand as preferred. Soccer players using both hands equally were found with a rate of 13.4%. In terms of foot preference, it was found that 22.83% of the participants used left foot and 43.48% of the participants used right foot as preferred. The soccer players using both feet equally was found as 33.70%. No significant difference was found between right handers and left handers in reaction time measurements when the soccer players were grouped by hand preference. When compared with left footed players (0.29 sec), only the right foot sound reaction time of right footed players was significantly shorter (0.21 sec) at p<. 05 level. Statistically significant correlation was found between soccer players’ hand and foot preference at a level of p< 0.01. Left footed players had significantly higher left leg mean squat (37.19 kg) when compared with right footed players (32.27 kg). No significant difference was found between right footed (35.36 kg) and left footed (33.98) subjects in terms of mean of right leg squat. Conclusion: According to the hand preference, the proportion of those who use equally two feet increased. Reaction times and force's squat of the dominant hands and feet were better. Training programs for soccer players planned according to individual characteristics including footedness may result in performance increase and decrease in injury as a result of reduced strength and reaction time asymmetry between legs and arms.
Simulation-based lateral transshipment policy optimization for s, S inventory control problem in a single-echelon supply chain network
Authors: Yetkin Ekren Banu , Arslan Bartu
Published: September 2019

Since it affects the performance of whole supply chain significantly, definition of correct inventory control policy in a supply chain is critical. Recent technological development enabled real time visibility of a supply network by horizontal integration of each node in a supply network. By this opportunity, inventory sharing among stocking locations is also possible in the effort of cost minimization in supply chain management.  Hence, lateral transshipment gained popularity and studies seeking the best lateral-transshipment policy is still under research. In this study, we aim to compare different lateral-transshipment policies for an s, S inventory control problem for a single-echelon supply chain network system. In this work, we consider a supply network with three stocking locations which may perform lateral transshipment among them when backorder takes place. We develop the simulation models of the systems in ARENA 14.5 commercial software and compare the performance of the policies by minimizing the total cost under a pre-defined fill rate constraint by using an optimization tool, OptQuest, integrated in that software. The results show that lateral transshipment works well compared to the scenario when there is no lateral transshipment policy in the network.
Experimental Calibration of a Biohydrogen Production Estimation Model
Authors: Dias Fernando G. , Vargas Jose V. C. , Yang Sam , Rosa Marcos P. , Santos Beatriz , Kava Vanessa M. , Balmant Wellington , Mariano Andre B. , Ordonez Juan C.
Published: September 2019

A dynamic physics-based model developed for the prediction of biohydrogen production in a compact tubular photobioreactor (PBR) was calibrated experimentally. The spatial domain in the model was discretized with lumped control volumes and the principles of classical thermodynamics, mass, species, and heat transfer were combined to derive a system of ordinary differential equations, whose solution was the temperature and mass fraction distributions across the entire system. Two microalgae species, namely, Acutodesmus obliquus and Chlamydomonas reinhardtii strain cc125, were cultured in triplicate with different culture media via indirect biophotolysis. Measured biomass and hydrogen concentrations were then used to adjust the specific microalgae growth and hydrogen production rates in the model based on residual sum of squares (RSS) and the direct search method. Despite its simplicity, the presented volume element model was verified to well predict both hydrogen and biomass concentration over time. The microalgae growth rate for each species was determined as 2.16 μalga,0 s−1 and 0.91 μalga,0 s−1 for A. obliquus and C. reinhardtii strain cc125, respectively, where μalga,0 is the specific growth rate of Scenedesmus almeriensis for given temperature and irradiance. The adjusted maximum hydrogen production rates for the local nonmutant A. obliquus and for C. reinhardtii strain cc125 were 1.3 × 10−7 s−1 and 4.1 × 10−7 s−1. Consequently, these hydrogen production rates were 59 times and 19 times smaller, respectively, than that for the mutant C. reinhardtii strain cc849.
Effects of Mainstream Turbulence Intensity and Coolant-to-Mainstream Density Ratio on Film Cooling Effectiveness of Multirow Diffusion Slot Holes
Authors: An Bai-Tao , Liu Jian-Jun , Zhou Si-Jing
Published: September 2019

Multirow film cooling is widely used in gas turbine airfoils cooling to cope with extremely high inlet temperature. The film cooling effectiveness of diffusion slot holes was measured in multirow arrays at a flat plate experimental facility using the pressure sensitive paints (PSP) technique. Emphasis was focused on the influence mechanism of mainstream turbulence intensity (Tu) and coolant-to-mainstream density ratio (DR) on film cooling effectiveness of multirow arrays with wide exit holes. The diffusion slot hole with exit width of 3.7D and 4.0D was, respectively, tested in three staggered arrays of P/D = 6 and S/D = 30, P/D = 6 and S/D = 20, and P/D = 9 and S/D = 20. Four blowing ratios varied from M = 0.5 to 2.0. The baseline condition (Tu = 3.5%, DR = 1.38) was compared with an increased Tu condition (Tu = 8.4%) and a decreased DR condition (DR = 0.97). The results showed that in two P/D = 6 arrays, increasing Tu decreased the multirow effectiveness considerably under all blowing ratios, but increasing Tu prominently restrained the film coalescence. The influences of Tu were more intense for the arrays with larger exit width holes and larger S/D. Decreasing DR increased multirow effectiveness obviously. The influences of DR tended to consistent for all arrays and the influences were relatively weak for high blowing ratios. In the P/D = 9 array, the superiority of large exit width hole disappeared completely, regardless of Tu and DR variations.
The Autoignition of Nuclear Reactor Power Plant Explosions
Authors: Leishear Robert A.
Published: September 2019

Explosive research proves that there is a common cause for most explosions in nuclear reactor power plants during normal operations and accident conditions. The autoignition of flammable hydrogen is a common cause for nuclear power plant explosions, where complex corrosion processes, nuclear reactions, and thermal-fluid transients autoignite explosions. Research evaluated increasingly complicated accidents. First, piping explosions occurred at Hamaoka and Brunsbuttel. Fluid transients compressed oxygen and flammable hydrogen to heat these gases to autoignition, where resultant explosions shredded steel pipes. This identical mechanism was responsible for pipe and pump damages to U.S. reactor systems since the 1950s, where water hammer alone has been assumed to cause damages. Small explosions inside the piping actually cause damages during nuclear reactor startups and flow rate changes. Second, explosions are caused by thermal-fluid transients during nuclear reactor restarts, following accidental nuclear reactor meltdowns. Disastrous explosions destroyed nuclear reactor buildings (RBs) at Fukushima Daiichi. Previously considered to be a fire, a 319 kilogram hydrogen explosion occurred at Three Mile Island (TMI). The explosion cause following each of these loss-of-coolant accidents was identical, i.e., after meltdowns, pump operations heated gases, which in turn acted as the heat source to autoignite sequential hydrogen explosions in reactor systems to ignite RBs. Third, the Chernobyl explosion followed a reactor meltdown that was complicated by a high energy nuclear criticality. The hydrogen ignition and explosion causes are more complicated as well, where two sequential hydrogen explosions were ignited by high-temperature reactor fuel.
Simulation of Flow Around a Cube at Moderate Reynolds Numbers Using the Lattice Boltzmann Method
Authors: Khan Majid Hassan , Sharma Atul , Agrawal Amit
Published: September 2019

This article reports flow behavior around a suspended cube obtained using three-dimensional (3D) lattice Boltzmann method (LBM)-based simulations. The Reynolds number (Re) range covered is from 84 to 770. Four different flow regimes are noted based on the flow structure in this range of Re: steady axisymmetric (84 ≤ Re ≤ 200), steady nonaxisymmetric (215 ≤ Re ≤ 250), unsteady nonaxisymmetric in one plane and axisymmetric in the other plane (276 ≤ Re ≤ 300), and unsteady nonaxisymmetric in streamwise orthogonal planes (339 ≤ Re ≤ 770). Recirculation length and drag coefficient follow inverse trend in the steady flow regime. The unsteady flow regime shows hairpin vortices for Re ≤ 300 and then it becomes structureless. The nature of force coefficients has been examined at various Reynolds numbers. Temporal behavior of force coefficients is presented along with phase dependence of side force coefficients. The drag coefficient decreases with increase in Reynolds number in the steady flow regime and the side force coefficients are in phase. Drag coefficients are compared with established correlations for flow around a cube and a sphere. The side force coefficients are perfectly correlated at Re = 215 and they are anticorrelated at Re = 250. At higher Reynolds numbers, side force coefficients are highly uncorrelated. This work adds to the existing understanding of flow around a cube reported earlier at low and moderate Re and extends it further to unsteady regime at higher Re.
Linear Instability of Liquid Sheets Subjected to a Transverse Electric Field
Authors: Cui Xiao , Fu Qing-Fei , Yang Lijun , Xie Luo , Jia Bo-Qi
Published: September 2019

A temporal linear instability analysis was performed for a liquid sheet moving around the inviscid gas in transverse electrical field. The fluid was described by the leaky-dielectric model, which is more complex and more comparable to the liquid electrical properties than existing models. As a result, the sinuous and the varicose modes exist, in which the dimensionless dispersion relation between wave number and temporal growth rate can be derived as a 3 × 3 matrix. According to this relationship, the effects of liquid properties on sheet instability were performed. It was concluded that, as the electrical Euler number (Eu), the ratio of gas-to-liquid density (ρ), Weber number (We), Reynolds number (Re), and the relative relaxation time (τ) increased, the instability of the sheet was enhanced. This work also compared the leaky-dielectric model with the perfect conductor model and found that the unstable growth rate in the leaky-dielectric model was higher than the one in the perfect conductor model. Moreover, as the ratio of gas-to-liquid improved, this difference decreased. Finally, an energy approach was adopted to investigate the instability mechanism for the two models.
Direct Numerical Simulation of the Flow in a Bare Rod Bundle at Different Prandtl Numbers
Authors: Lai Jonathan K. , Busco Giacomo , Merzari Elia , Hassan Yassin A.
Published: September 2019

A direct numerical simulation (DNS) of bare rod bundles with a low pitch-to-diameter ratio is performed with heat transfer at different Prandtl numbers. Turbulence statistics for temperature and velocity as well as the turbulent budgets have been collected. High-fidelity simulations are performed with the spectral element method (SEM) using Nek5000, a highly scalable code. To pertain to industrial-related flows, a rod bundle model is based on Hooper and Wood's (Hooper, J. D., and Wood, D., 1984, “Fully Developed Rod Bundle Flow Over a Large Range of Reynolds Number,” Nucl. Eng. Des., 83(1), pp. 31–46) experimental setup. Both wall normalized velocity profile and turbulent kinetic energy are validated with a Reynolds number of 22,600. Kolmogorov length scales and time scales are calculated to be within the simulation's spatial–temporal resolution. Moreover, gap vortices and coherent structures are quantified by using Lambda2 vortex criterion, frequency analysis, and two-point correlation. Heat transfer statistics are discussed with a constant heat flux for six different Prandtl numbers ranging from 2 to 0.002. This range shows significantly different characteristics in temperature for both mean and variance. Mean temperature profiles in the subchannel center are very sensitive to the Prandtl number when it becomes small. It is also found that the location of the local maxima for the variance of temperature fluctuations becomes very sensitive at larger Prandtl numbers. The temperature frequency analysis reveals a shift to lower frequencies for low Prandtl numbers. The DNS results provided in this work will contribute as benchmark for the improvement and development of existing and new turbulent heat transfer models at different Prandtl number regimes.