bluuebunny/crossref_metadata_2025 huggingface dataset:
Biologically Aware Lighting for Newborn Intensive Care
Authors: Greenberg James , Gruner Katherine , Rodney Lousette , Struve Jaime , Kang Daniel , Cao Yuying , Lang Richard
Published: July 2023

Objective: We designed and implemented a novel neonatal intensive care (NICU) lighting system to support current understanding of sunlight-coupled physiology.
Methods: We created a system that generates wavelengths corresponding to the known blue and violet activation spectra of non-visual opsins. These are known to mediate energy management and related physiologic activity.
Results: Light produced by the system spans the visible spectrum, including violet wavelengths that are blocked by modern glazing and not emitted by standard LED fixtures. System features include automated light and dark phases that mimic dawn/dusk. The system also matches length of day seasonality. Spectral composition can be varied to support translational research protocols. Implementation required a comprehensive strategy to inform bedside providers about the value and use of the lighting system.
Conclusion: Full-spectrum lighting for the NICU is feasible and will inform optimization of the NICU environment of care to support optimal neonatal growth and development.
The impact of exercise on executive function in overweight and obese children and adolescents: a systematic review and meta-analysis
Authors: Li Shun , Li Zeng yi , Sun Xin yu , Chen Chao
Published: July 2023

OBJECTIVE: To investigate the effects of exercise on executive function in overweight and obese children and adolescents. METHODS: Four databases, including Pubmed, Web of Science, EBSCOHost, and China Knowledge Network, were selected to search for empirical studies related to the effect of exercise on executive function in overweight and obese children and adolescents, and the included literature was assessed for risk bias, and combined effect sizes and subgroup analyses were performed using STATA 14.1 software.
RESULTS: 1) The nine included papers were predominantly moderately biased and contained a total of 764 subjects; 2) exercise significantly affected the development of executive function in overweight and obese children and adolescents (SMD=-0.432, 95% CI: -0.764, -0.099, p<0.05), but there were differences between subcomponents that significantly affected the development of working memory and inhibitory control ( SMD=-1.09, 95% CI: -1.94, -0.24, P<0.05; SMD=-0.41, 95% CI: -0.76, -0.06, P<0.05) and did not significantly affect the development of cognitive flexibility. (SMD=-0.09, 95% CI: -0.85, 0.67, P>0.05); 3) Acute exercise can significantly affect the development of executive function in overweight and obese children and adolescents compared to long-term intervention (SMD=-0.456, 95% CI: -0.893, -0.019, P<0.05); 4) Acute exercise can be performed with a single duration of 40 min (SMD= -1.172, 95% CI: -1.547, -0.706, P<0.01), moderate intensity (SMD= -0.53, 95% CI: -1.04, -0.02, P<0.05), basketball combined with jump rope (SMD= -0.822, 95% CI: - 1.012, -0.632, P<0.01).
Conclusions: 1) exercise improves inhibitory control and working memory in overweight and obese children and adolescents; 2) acute exercise is effective in improving executive function in overweight and obese children and adolescents; and 3) basketball combined with jump rope exercise of single duration 40 min and moderate intensity (60%-69% HRmax) is recommended to improve executive function in overweight and obese children and adolescents.
Domain Adaptation via Wasserstein Distance and Discrepancy Metric for Chest X-ray Image Classification
Authors: He Bishi , Chen Yuanjiao , Zhu Darong , Xu Zhe
Published: July 2023

Deep learning technology can effectively assist physicians in diagnosing chest radiographs. Conventional domain adaptation methods suffer from inaccurate lesion region localization, large errors in feature extraction, and a large number of model parameters. To address these problems, we proposes a novel domain adaptation method called WDDM, which joints Wasserstein distance and discrepancy metric for chest radiograph abnormality identification. Specifically, our method uses BiFormer as a multi-scale feature extractor to extract deep feature representations of data samples, which focuses more on discriminant features than convolutional neural networks and Swin Transformer. In addition, based on the loss minimization of Wasserstein distance and contrast domain differences, the source domain samples closest to the target domain are selected to achieve similarity and dissimilarity across domains. Experimental results show that our method improves the mean value of AUC of chest radiograph classification by no less than 14.8% against the unmigrated methods which classify the target domain by training the resulting network directly with the source domain. In short, our method achieves higher classification accuracy and better generalization performance.
Structurally unstable quadratic vector fields of codimension two: families possessing one finite saddle-node and a separatrix connection
Authors: Artés Joan C.
Published: July 2023

This paper is part of a series of works whose ultimate goal is the complete classification of phase portraits of quadratic differential systems in the plane modulo limit cycles. It is estimated that the total number may be around 2000, so the work to find them all must be split in different papers in a systematic way so to assure the completeness of the study and also the non intersection among them. In this paper we classify the family of phase portraits possessing one finite saddle-node and a separatrix connection and determine that there are a minimum of 77 topologically different phase portraits plus at most 16 other phase portraits which we conjecture to be impossible. Along this paper we also deploy a mistake in the book [5] linked to a mistake in [38].
2000 Mathematics Subject Classification: 34C23, 34A34, 37G10
Bioinspired, Ultra-Light and Sandwich structured MXene-AgNWs/cellulose nanofiber porous film for excellent electromagnetic interference shielding with Joule Heating Performance
Authors: Ren Fang , Zhang Jiale , Wu Tong , Zhang Fudong , Guo Zhengzheng , Jin Yanling , Ren Penggang
Published: July 2023

With the rapid development and popularization of intelligent, portable, and wearable flexible electronic devices, urgently required a new generation electromagnetic interference (EMI) shielding materials to manage the increasing serious radiation pollution. In this work, ultrathin, lightweight, and flexible porousfilms with reasonable strength were fabricated via vacuum filtered the cellulose nanofiber (CNF) dispersion on both sides of the MXene-AgNWs film and followed by a freeze-drying process. The prepared porous composite film presents to be a typical sandwich-structured with dense in surface and porous inside. This novel and unique structure endows the sandwich-structured porous film with greatly improved EMI performance to 67.5 from 40 dB, enhanced absorption coefficient from 0.1 to 0.4, and satisfactory mechanical properties compared to the conventional sandwich-structured films. Furthermore, the prepared films present the remarkable low-voltage-driven Joule heating performance. Therefore, ultrathin, lightweight, flexible, and versatile properties CNF-MXene-AgNWs composite porous film with an excellent EMI-shielding performance is hold great potential in the fields of aerospace, portable and wearable electronics.
Perioperative risk factors of pressure injuries in Korean patients after surgery for intracranial hemorrhage: A retrospective cohort study
Authors: Choi On-You , Son Youn-Jung
Published: July 2023

Neurosurgical patients are more likely to develop pressure injuries caused by long operation time and decreased consciousness. However, there is a lack of knowledge on the perioperative risk factors of pressure injuries among neurosurgical patients in Korea. Thus, this study aimed to identify the incidence and perioperative risk factors of post-operative pressure injuries in patients after brain surgery. This retrospective cohort study was conducted in a tertiary care university hospital in Korea. Patients who underwent surgery for treating intracranial hemorrhage were included. Data from medical records for analysis were collected between April 2010 to March 2020. Among the 386 patients, 103 patients (26.7%) developed postoperative pressure injuries. The most common site of pressure injury was the coccyx (n = 56, 38.9%). About more than half of patients were in stage Ⅱ and the 43 (41.7%) patients developed pressure injuries after 14 days of post-surgery period. Multivariable logistic regression revealed that being older age (p = .025), receiving packed red blood cells transfusion during intensive care unit stay (p = .004), and staying in the intensive care unit for more than 7 days (p < .001) increased the risk of pressure injury after brain surgery. Older adults with longer stay in neurosurgical intensive care units and requiring blood transfusion should be carefully assessed to prevent pressure injuries within 7 days of intensive care unit admission. Postoperative pressure injuries of neurosurgical patients can be prevented by effective handover communication at intra-and inter-departmental level.
Beyond Color and Pattern: Elucidating the Factors Associated with Intraspecific Aggression in the Mimic Poison Frog (Ranitomeya imitator)
Authors: Bieri Eli , Rubio Andrew O. , Summers Kyle
Published: July 2023

Assortative or disassortative aggression – when individuals display more aggression towards conspecifics with similar or different phenotypic characteristics – can either maintain polymorphisms or facilitate gene flow between populations depending on which direction the aggression is aimed. Deciphering which factors elicit or prevent aggression is crucial to improving our knowledge of the origin and maintenance of reproductive barriers and subsequent speciation. The Peruvian mimic poison frog, Ranitomeya imitator, is a monogamous and territorial species that has evolved into four distinct color-pattern morphs in a mimetic radiation. Here we use historical landscape genetic data and competition trials between male individuals sourced from different populations and color-pattern morphs to show that the level of aggression between individuals is not associated with color morph or body size but rather with source population. Individuals spent more time in combat with individuals from their own deme (genetically homogeneous population), irrespective of color morph or size. These findings indicate that genotypic similarity is correlated with increased aggression in R. imitator, though the mechanism by which R. imitator males identify conspecifics as territorial threats remains unclear. As body size and color morph were not significantly associated with aggression levels, this study emphasizes the necessity of further research to identify whether other phenotypic traits are influencing territorial behavior between male frogs, and if these factors play a role in increasing gene flow, or conversely, the formation of reproductive barriers between populations.
Effect of water retting on the chemical composition of Calotropis gigantea fibres: Analysis using FTIR Spectroscopy
Authors: Rajasekaran Priyadarshini , Sivasamy Muhilarasi , Thirumani Geetha , Arunachalam Sakthi Maheswari , Loganathan Kaavya
Published: July 2023

The use of unconventional natural fibres such as bast fibres from several plants is gaining importance as conventional natural fibres such as cotton, wool, silk are considered less sustainable fibres for several reasons such as the massive water and pesticide consumption for cultivation in case of cotton for instance. The need for sustainable fibres to partly replace these conventional fibres is gaining importance in the field of apparel and textiles. In this study, we have attempted to extract fibres from the stems of Calotropis gigantea using standing water and without any additives, for a period of 3 days. The FTIR spectroscopy of dry extracted calotropis fibres and water-retted fibres was performed. It is observed the effect of water retting is significant and there is a remarkable decrease in the lignin and pectin content. In addition, it is also noticed that the hemi-cellulose content in the fibre also decreased. This shows that water retting is also an efficient and sustainable method for fibre extraction from Calotropis gigantea.
How can healthcare organisations increase doctors’ research engagement? A scoping review
Authors: Brandenburg Caitlin , Stehlik Paulina , Noble Christy , Wenke Rachel , Jones Kristen , Hattingh Laetitia , Dungey Kelly , Brandjerdporn Grace , Spillane Ciara , Kalantari Sharmin , George Shane , Keijzers Gerben , Mickan Sharon
Published: July 2023

Clinician engagement in research has positive impacts for healthcare, but is often difficult for healthcare organisations to support in light of limited resources. This scoping review aimed to describe the literature on health service-administered strategies for increasing research engagement by medical practitioners. Medline, EMBASE and Web of Science databases were searched from 2000-2021 and two independent reviewers screened each record for inclusion. Inclusion criteria were that studies: sampled medically qualified clinicians; reported empirical data; investigated effectiveness of an intervention in improving research engagement; and addressed interventions implemented by an individual health service/hospital. Of the 11,084 unique records, 257 studies were included. Most (78.2%) studies were conducted in the United States, and were targeted at residents (63.0%). Outcomes were measured in a variety of ways, most commonly publication-related outcomes (77.4%), though many studies used more than one outcome measure (70.4%). Pre-post (38.8%) and post-only (28.7%) study designs were the most common, while those using a contemporaneous control group were uncommon (11.5%). The most commonly reported interventions included Resident Research Programs (RRPs), protected time, mentorship, and education programs. Many articles did not report key information needed for data extraction, (e.g. sample size). Despite a large volume of research, poor reporting, infrequent use of robust study designs and heterogenous outcome measures limit application of these studies and prospects for future systematic reviews/meta-analyses. The most compelling available evidence pointed to RRPs, protected time and mentorship as effective interventions. Further high-quality evidence is needed to guide healthcare organisations on increasing medical research engagement.
Clinical Characteristics and Short-term Outcomes of Acute Pancreatitis with COVID-19
Authors: Zhang Jinchang , luo De , kang Maoji , Li Bo , Su Song
Published: July 2023

Introduction:
The existing literature on the combination of acute pancreatitis (AP) and COVID-19 is scarce. The objective of our study is to compare the clinical outcomes and occurrence of long COVID syndrome in AP patients with and without COVID-19, while investigating the potential impact of COVID-19 on the severity, mortality rate, and long COVID syndrome in these patients.
Materials and methods
This retrospective, observational study was conducted at a single center. It included patients aged 18 years and above who were diagnosed with AP during the pandemic. Patients were categorized into two groups based on the results of RT-qPCR testing: the COVID-19 positive group and the COVID-19 negative group. The study aimed to compare the severity of AP, mortality rate, and occurrence of long COVID syndrome between these two groups.
Result
A retrospective review was conducted on 122 patients diagnosed with acute pancreatitis between December 1, 2022, and January 31, 2023. Out of these patients, 100 were included in the study. The analysis revealed no significant differences in mortality rate, severity, and sequelae between AP patients with COVID-19 and those without COVID-19 (p > 0.005). However, a statistically significant difference was observed in the occurrence of long COVID syndrome, specifically in the presence of cough (P = 0.04).
Conclusion
This study demonstrates that the presence of COVID-19 in patients with pancreatitis does not lead to an increase in the mortality and severity rate of pancreatitis.
Impact of using single files rotary system on the quality of root canal treatment treated by undergraduate students
Authors: Ameen Martwa , Alhadi Dunia , Almaslamani Manal , Saleh Abdul Rahman
Published: July 2023

Introduction: The aim of this study is to evaluate the influence of using a single-file reciprocating system on the technical quality of root canal filling and treatment radiographically for cases treated by undergraduate students.
Materials and Methods: This is a retrospective cross-sectional clinical study for endodontically treated teeth by 4th-year undergraduate students during the academic year 2021-2022. Root canal preparation was performed using the WaveOne Gold system with a matching single-cone gutta percha. The collected data included gender, tooth position, number of canals, and timing of treatment (the first or second semester). The quality of the root canal filling was assessed based on root canal filling length, density, and taper. The presence of ledge, apical transportation, perforation, and separated instrument were recorded.
Results: The total number of teeth included in the study was 601. The length of the root canal filling was adequate in 93.51% of the teeth, underfilled in 2.82%, and overfilled in 3.66%. The density and taper were adequate in 96.5% and 98.16% of the teeth, respectively. There was no significant difference among the parameters of length, taper, density, and all procedural errors in relation to the arch type. However, there was a significant difference between anterior and premolar teeth in regards to taper, density, and overall quality of root canal filling. The overall quality of root canal treatment was acceptable in 527 teeth (87.68%), with no significant difference between the teeth (P = 0.256).
Conclusion: The quality of root canal treatment performed by undergraduate students has improved with the use of a single-file reciprocating system for preparation.
The Green BIM Process Model for Efficient Information Exchange in Sustainable Building Design
Authors: Ohueri Chukwuka Christian , Masrom Md Asrul , Bamgbade Jibril Adewale , Enegbuma Wallace Imoudu
Published: July 2023

The adequate application of Building Information modeling (BIM) in sustainable building design known as green BIM, ensures the exchange of accurate information to reduce the buildings' carbon emissions and enhance the overall sustainability performance. However, a major challenge in sustainable building design is the persistent exchange of inaccurate data, resulting in flawed decisions. This study develops a Green BIM Process Model to explicitly guide the multidiscipline team to use the diverse BIM software to efficiently exchange cumbersome sustainability information. The process model focuses on building massing; fabric and layout optimization; and mechanical electrical & plumbing systems. After a critical literature review, the major components of efficient information exchange in the BIM-based sustainable building design process were established. Then, an in-depth interview was conducted with 26 construction professionals and analyzed using the narrative analysis technique. As a result, the best practices for the holistic coordination of the established major components were ascertained. Afterward, the Green BIM Process Model was developed by using Integrated DEFinition techniques to explicitly model the relationship between the established major components. The novel Green BIM Process Model provides a pragmatic approach that defines how the multidiscipline team can exchange accurate information and in turn, make viable decisions that can enhance the sustainability performance of buildings.
Extracellular matrix protein 1 (ECM1) is a potential biomarker in B-cell acute lymphoblastic leukemia
Authors: Wu Li-Xin , Zhao Ming-Yue , Zhou Ya-Lan , Cao Lei-Ming , Qin Ya-Zhen , Jiang Hao , Jiang Qian , Xu Lan-Ping , Zhang Xiao-Hui , Huang Xiao-Jun , Ruan Guo-Rui
Published: July 2023

B-cell acute lymphoblastic leukemia (ALL) is characterized by the highly heterogeneity of pathogenic genetic background, and there are still approximately 30-40% of patients without clear molecular markers. To identify the dysregulated genes in B-cell ALL, we screened 30 newly diagnosed B-cell ALL patients and 10 donors by gene expression profiling chip. We found that ECM1 transcript level was abnormally elevated in newly diagnosed B-cell ALL and further verified in another 267 cases compared with donors (median, 124.57% vs. 7.14%, P<0.001). ROC analysis showed that the area under the curve of ECM1transcript level at diagnosis was 0.89 (P <0.001). Patients with BCR::ABL1and IKZF1 deletion show highest expression level (210.78%) compared with KMT2A rearrangement (39.48%) and TCF3::PBX1 rearrangement ones (30.02%) (all P <0.05). Also, the expression level of ECM1 was highly correlated with the clinical course, as 20 consecutive follow-up cases indicated. The 5-year OS of patients (non-KMT2A and non-TCF3::PBX1rearrangement) with high ECM1 transcript level was significantly worse than the lower ones (18.7% vs. 72.9%, P <0.001) and high ECM1transcript level was an independent risk factor for OS (HR=5.77 [1.75-19.06], P=0.004). After considering transplantation, high ECM1 transcript level was not an independent risk factor, although OS was still poor (low vs.high, 71.1% vs. 56.8%, P =0.038). Our findings suggested that ECM1may be a potential molecular marker for diagnosis, minimal residual disease (MRD) monitoring, and prognosis prediction of B-cell ALL.
Trial Registration
Trial Registration Registered in the Beijing Municipal Health Bureau Registration N 2007–1007 and in the Chinese Clinical Trial Registry [ChiCTR-OCH-10000940 and ChiCTR-OPC-14005546]; http://www.chictr.org.cn.
Imaging prediction of malignant and benign neoplasms in the salivary gland using two-phase multislice spiral CT texture analysis
Authors: jiang Shuqi , Su Yangfan , Liu Yanwen , Zhou Zewang , Li Maotong , Qiu Shijun , Zhou Jie
Published: July 2023

Background
Parotid lesions show overlapping morphological findings and types of time/intensity curves. This research aimed to evaluate the role of two-phase multislice spiral computed tomography (MSCT) texture analysis in differentiating between benign and malignant parotid lesions.
Methods
In this retrospective research, MSCT was carried out on 90 patients. Each lesion was segmented on axial CT images by manually, and 33 texture features and morphologic CT features were assessed. Logistic regression analysis was used to identify predictors of malignancy (P < 0.05 was considered statistically significant), followed by receiver operating characteristic (ROC) analysis to determine diagnostic efficacy.
Results
Univariate logistic regression analysis demonstrated that morphological CT features (shape, size, and invasion of adjacent tissues) and 17 CT texture parameters were significant differences between benign and malignant lesions (P < 0.05). Multivariate binary logistic regression demonstrated that shape, invasion of adjacent tissues, entropy and inverse difference moment were independent factors for malignant tumours. The diagnostic accuracy of multivariate binary logistic models based on morphological parameters, CT texture features, and a combination of both was 87.8%, 90%, and 93.3%, respectively.
Conclusion
Two-phase MSCT texture analysis was conducive to differentiating between malignant and benign neoplasms in the salivary gland, especially when combined with morphological CT features.
Exploring the feasibility of introducing triple artemisinin-based combination therapies in the malaria treatment policy in Vietnam
Authors: Cao Thi Van Anh , de Haan Freek , Duong Le Quyen , Boon Wouter P. C. , Moors Ellen H. M. , Dondorp Arjen M. , Amaratunga Chanaki , Nguyen Quang Thieu
Published: July 2023

Introduction:
This study investigates the processes regarding changing malaria treatment policies in Vietnam. Moreover, it explores the feasibility of introducing triple artemisinin-based combination therapies (TACTs) in Vietnam to support the national malaria control and elimination plan.
Methods
Data were collected through desk review of policy documents in combination with 12 in-depth interviews with key stakeholders.
Results
TACTs are considered as a useful backup strategy in case future treatment failures with current artemisinin-based combination therapies (ACTs) would occur. Moreover, TACTs are also considered as a promising strategy to prevent the re-establishment of malaria. However, regulatory procedures and implementation timelines for TACTs were expected to be lengthy. Therefore, stakeholder engagement strategies should be initiated soon, stipulating the benefits of TACTs deployment. A simplified validation of registration or an import permit without registration that has been applied to the introduction of artesunate-pyronaridine was proposed to accelerate the introduction of TACTs. Global-level support through WHO recommendations and prequalification were considered critical for supporting the introduction of TACTs in Vietnam.
Conclusions
Appropriate approach strategies and early stakeholder engagement will be needed to accelerate the introduction of TACTs in Vietnam.
Association Between Frequency of Breakfast Intake Before and During Pregnancy and Developmental Delays in children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Authors: Aizawa Misato , Murakami Keiko , Takahashi Ippei , Ohseto Hisashi , Noda Aoi , Shinoda Genki , Orui Masatsugu , Ishikuro Mami , Obara Taku , Hamada Hirotaka , Iwama Noriyuki , Saito Masatoshi , Sugawara Junichi , Kuriyama Shinichi
Published: July 2023

Background Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association between the timing of food intake and developmental delays remains unclear. Herein, we examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children.Methods Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7786 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5–6, 3–4, and 0–2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years.Results The proportion of pregnant women who had breakfast daily was 78.2% in pre- to early pregnancy, and 82.3% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0–2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.33, (95% confidence interval [CI], 1.06–1.68). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0–2 times/week in early to mid- pregnancy: OR 1.79 (95% CI, 1.36–2.36). Compared with children of women who had breakfast daily from pre- to early and early to mid-pregnancy, children of women who had breakfast 0–2 times/week were not associated with developmental delays at age 3.5 years: OR 1.11 (95% CI, 0.86–1.44 and OR 1.19 (95% CI 0.87–1.62), respectively.Conclusion For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.
Prognostic significance of post-preoperative tumor markers increments in patients with non-metastatic gastric cancer
Authors: Zhu Xiao-Dong , Zhang Li-Xiang , Luo Pan-Quan , Zhu Hai , Wei Zhi-Jian , Xu A-Man
Published: July 2023

Purpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are the most common tumor markers detected before and after gastric cancer (GC) surgery. However, the impact of post-preoperative CEA/CA19-9 increments on prognosis of GC remains unclear. In addition, there is no research incorporating post-preoperative CEA/CA19-9 increments into the prognostic model.
Methods: Patients who underwent radical gastrectomy for GC at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital from January 2013 to December 2017 were enrolled and divided into the discovery and validation cohort. Prognostic value of post-preoperative CEA/CA19-9 increments and preoperative CEA/CA199 levels were assessed by Kaplan-Meier log-rank analysis and compared by time-dependent receiver operating characteristic (t-ROC) curves. Multivariate Cox regression analysis was applied to establish the nomogram. The performance of the prognostic model was validated by the concordance index (C-index), calibration curve, and ROC curve analysis.
Results: A total of 562 GC patients were included in this study. Overall survival (OS) rates decreased with an increasing number of incremental tumor markers after surgery. The t-ROC curves implied that the prognostic ability of the number of incremental post-preoperative tumor markers was superior to that the number of positive preoperative tumor markers. Cox regression analysis suggested that the number of incremental post-preoperative tumor markers was an independent prognostic factor. The nomogram which incorporated with the post-preoperative CEA/CA19-9 increments showed reliable accuracy.
Conclusions: Incremental post-preoperative CEA/CA19-9 were indicator of poor prognosis of GC. The prognostic value of post-preoperative CEA/CA19-9 increments exceed that of preoperative CEA/CA19-9 levels.
Effect of superovulatory dose of FSH on follicular development, atresia, and endocrine changes during superovulation protocol in Sahiwal Zebu Cows
Authors: Chandra Pradeep , Kumar Brijesh , Singh Sushobhit K. , Kohli Kalpendra , . Bhagirathi , . Vandana , Patra M. K. , Chouhan V. S. , Khan M. H. , Das G. K. , Kumar Harendra , Dutt Triveni , Singh S.K.
Published: July 2023

Background
In the recent past, the antral follicle count (AFC), of an ovary, has been indicated as an important phenotypic characteristic related to female fertility and closely correlated to the performance of in vivo and in vitro embryo production. However, most of the follicles undergo degeneration at the early antral stage rather than the preantral and preovulatory stages. FSH has been considered a follicle survival factor. Therefore, the present study aimed to find the effect of superovulatory dose of FSH on follicular development, atresia rate, endocrine changes, and super ovulatory estrus characteristics in Sahiwal cows.
Methods
A total of 24 Sahiwal cows were divided into two groups. Simulated and non-stimulated groups. In the stimulated group, Sahiwal donors (n = 12) were superstimulated using pFSH during the mid-luteal phase and the same number of cyclic Sahiwal cows (n = 12) were monitored through trans-rectal ultrasonography for comparative follicular-endocrine changes in the stimulated and non-stimulated group.
Results
At the initiation of FSH administration (10th day), on the day of prostaglandin (PG) injection (12th day), and at super ovulatory estrus (SOE/14th day) significantly greater number of small, medium, and large follicles were recorded, respectively. However, similar changes were not found on the respective days of the oestrus cycle in non-stimulated cows. The number of surface follicles undergoing atresia was significantly higher (P < 0.01) in the non-stimulated than in the stimulated group. On the day of SOE, the greater number of preovulatory follicles (POF) was positively correlated with the number of small follicles in the ovary at the initiation of superovulatory (SO) treatment and ovarian dimension at SOE.
Conclusions
The administration of pFSH increased the total number of the large follicle population by preventing the atresia of the small follicle and propelling the cohort of the follicle in a continuous growth phase thereby the significantly higher number of POF recorded on the day of SOE and contributing to increased peripheral E2 concentration. Thus, the majority of SO animals exhibited high estrus intensity for a prolonged period than normal cycling Sahiwal cows.
Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer
Authors: Zang Longjun , Zhang Baoming , Zhou Yanling , Zhang Fusheng , Tian Xiaodong , Tian Zhongming , Chen Dongjie , Miao Qingwang
Published: July 2023

Background: Pancreatic cancer (PC) is a digestive malignancy with worse overall survival and we aimed to detect the TIME-related classifier to facilitate the personalized treatment of PC.
Methods: Unsupervised consensus clustering and multiple machine-learning algorithms were implemented to construct the immune-related signature (IRS). scRNA-seq analysis was conducted to explore the regulatory mechanism of IRS on TIME in PC. Finally, pharmacogenomic databases were enrolled to treat high IRS patients.
Results: We classified patients into Immune_rich and Immune_desert subgroups. Next, the IRS model was established based on 8 IRGs (SYT12, TNNT1, TRIM46, SMPD3, ANLN, AFF3, CXCL9 and RP1L1) and validated its predictive efficiency in multiple cohorts. RT-qPCR experiments demonstrated the differential expression of 8 IRGs between tumor and normal cell lines. Patients who gained lower IRS score tended to be more sensitive to chemotherapy and immunotherapy, and obtained better overall survival compared to those with higher IRS score. Moreover, scRNA-seq analysis revealed that fibroblast and ductal cells might affect malignant tumor cells via MIF-(CD74+CD44) and SPP1-CD44 axis. Eventually, we identified eight therapeutic targets and one agent for IRS high patients.
Conclusion: Our study screened out the specific regulation pattern of TIME in PC, and shed light on the precise treatment of PC.
Thermochromic wool fabric was prepared via grafting thiol-modified thermochromic microcapsule
Authors: xue tong , Yin yunjie
Published: July 2023

Thermochromic microcapsules have excellent reversible discoloration and encapsulation properties and have been widely used in the development of color-changing smart textiles. However, there are few reports on the graft modification of microcapsules to form covalent bonds with fabrics. In this study, mercapto-modified thermochromic microcapsules are successfully introduced into wool fabric utilizing cleavage and reconstruction of disulfide bonds in wool fibers. DSC results showed that the phase transition temperature of the microcapsules was 48.98℃., and the wool fabric treated with thiol-modified thermochromic microcapsules has excellent color fastness. When the amount of 3-Mercaptopropyltriethoxysilane accounted for 10% of Tetraethyl orthosilicate, The color-changing polar fleece fabric is grade 3 in fade resistance, grade 5 in fade resistance, grade 3 in wet rub resistance, and grade 4 in dry rub resistance. The microcapsules-treated wool fabric has good reversible thermochromic properties. Even after 30 times of heating and cooling experiments, the K/S value of thermochromic woolen fabric remains unchanged.
Identification of epigenetically regulated genes involved in plant-virus interaction and their role in virus-triggered induced resistance
Authors: Corrêa Régis L. , Kutnjak Denis , Ambrós Silvia , Bustos Mónica , Elena Santiago F.
Published: July 2023

Background
Plant responses to a wide range of stresses are known to be regulated by epigenetic mechanisms. Pathogen-related investigations, particularly against RNA viruses, are however scarce. It has been demonstrated that Arabidopsis thaliana plants defective in some members of the RNA-directed DNA methylation (RdDM) or histone modification pathways presented differential susceptibility to the turnip mosaic virus. In order to identify genes directly targeted by the RdDM-related RNA Polymerase V (POLV) complex and the histone demethylase protein JUMONJI14 (JMJ14) during infection, the transcriptomes of infected mutant and control plants were obtained and integrated with available chromatin occupancy data for various epigenetic proteins and marks.
Results
A comprehensive list of virus-responsive gene candidates to be regulated by the two proteins was obtained. Twelve genes were selected for further characterization, confirming their dynamic regulation during the course of infection. Several epigenetic marks on their promoter sequences were found using in silico data, raising confidence that the identified genes are actually regulated by epigenetic mechanisms. The altered expression of six of these genes in mutants of the methyltransferase gene CURLY LEAF and the histone deacetylase gene HISTONE DEACETYLASE 19 suggests that some virus-responsive genes may be regulated by multiple coordinated epigenetic complexes. A temporally separated multiple plant virus infection experiment in which plants were transiently infected with one virus and then infected by a second one was designed to investigate the possible roles of the identified POLV- and JMJ14-regulated genes in wild-type (WT) plants. Plants that had previously been stimulated with viruses were found to be more resistant to subsequent virus challenge than control plants. Several POLV- and JMJ14-regulated genes were found to be regulated in virus induced resistance in WT plants, with some of them poisoned to be expressed in early infection stages.
Conclusions
A set of confident candidate genes directly regulated by the POLV and JMJ14 proteins during virus infection was identified, with indications that some of them may be regulated by multiple epigenetic modules. A subset of these genes may also play a role in the tolerance of WT plants to repeated, intermittent virus infections.
Analgesic Efficacy of Collagen Peptide in Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials
Authors: Lin Chun-Ru , Tsai Sung Huang Laurent , Huang Ko-Yen , Tsai Po-An , Chou Hsuan , Chang Shu-Hao
Published: July 2023

Background:
The management of knee osteoarthritis involves various treatment strategies. It is important to explore alternative therapies that are both safe and effective. Collagen peptides have emerged as a potential intervention for knee osteoarthritis. This study aims to evaluate the analgesic effects and safety of collagen peptide in patients diagnosed with knee osteoarthritis.
Methods:
We conducted a systematic literature search following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Multiple databases including PubMed, Scopus, EMBASE, Web of Science, Cochrane, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) published up to 27 May, 2023 that focused on the analgesic outcomes and adverse events associated with collagen peptides or hydrolyzed collagen in patients with osteoarthritis. We assessed the quality of the included studies and the strength of evidence using the Cochrane ROB 2.0 tool and Grading of Recommendations, Assessment, Development, and Evaluations.
Results:
Four trials involving 507 patients with knee osteoarthritis were included and analyzed using the random-effects model. All of these trials were considered to have a high risk of bias. Our results revealed a significant difference in pain relief between the collagen peptide group and the placebo group in patients with knee osteoarthritis (standardized mean difference of the mean difference: -0.63; 95% CI: -0.86, -0.39, p < 0.00001; I2: 52%; quality of evidence: moderate). However, there was no significant difference in the risk of adverse events between collagen peptide and placebo (odds ratio: 1.66; 95% CI: 0.99, 2.78, p = 0.05; I2: 0%; quality of evidence: very low).
Conclusions:
Our findings demonstrate significant pain relief in patients with knee osteoarthritis who received collagen peptides compared to those who received placebo. In addition, the risk of adverse events did not differ significantly between the collagen peptide group and the placebo group. However, due to potential biases and limitations, well-designed randomized controlled trials are needed to validate and confirm these findings.
ORGRU: Online Robust Gated Recurrent Units for Real-Time Background Subtraction in Video Sequences
Authors: Sedghi Arezoo , Amoozegar Maryam , Rashedi Esmat , Afsari Fatemeh
Published: July 2023

Background subtraction is a crucial task in computer vision that involves segmenting video frames into foreground and background regions. While deep learning techniques have shown promise in this field, existing approaches typically rely on supervised learning and have limited generalization capabilities for unseen video data. Moreover, many of these methods are not suitable for real-time applications due to their offline or partially online nature. This paper introduces ORGRU, an unsupervised, online, and robust deep learning-based framework for background subtraction. ORGRU utilizes a robust version of Gated Recurrent Units (GRUs) to simultaneously estimate and maintain the background model as the low-rank component while calculating the sparse section as the foreground in a fully online manner. The model is iteratively updated in real time with an unsupervised learning algorithm utilizing only the current frame. To evaluate the effectiveness of the proposed approach, we conduct experiments on the LASIESTA dataset, which is a comprehensive, fully-labeled dataset for change detection covering various background subtraction challenges. The experimental results provide both qualitative and quantitative assessments, demonstrating the robustness and superiority of the proposed approach compared to the state-of-the-art methods.
Feature Selection via ACO
Authors: Eroglu Duygu Yilmaz , Akcan Umut
Published: July 2023

Developing information technologies bring about a huge amount of data which is growing exponentially each day. That large and multidimensional data increases computational costs and makes it difficult to extract meaningful information from the data. Feature selection aims to reduce the multidimensionality of the data while keeping information loss at a minimum level. Different approaches have been proposed for feature selection which may be classified as filter, wrapper, embedded, and hybrid methods. A novel hybrid Feature Selection approach via Ant Colony Optimization Algorithm (FSvACO) is proposed in this paper. The performance of the proposed algorithm is verified by comparing the alternative feature subset selection algorithms in the literature. Additional studies demonstrated that developed FSvACO can eliminate the irrelevant features for most datasets selected from a varied number of features, multi-classes, and a diverse number of instances.
Controversies regarding Lithium-associated weight gain: Case-control study of real-world drug safety data
Authors: Greil Waldemar , Bardeci Mateo , Müller-Oerlinghausen Bruno , Nievergelt Nadja , Stassen Hans , Hasler Gregor , Erfurth Andreas , Cattapan Katja , Rüther Eckart , Seifert Johanna , Toto Sermin , Bleich Stefan , Schoretsanitis Georgios
Published: July 2023

Background The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers compared to lamotrigine which is considered free of metabolic adverse drug reactions (ADRs).Methods We conducted a case/non-case pharmacovigilance study using data from the AMSP project (German: "Arzneimittelsicherheit in der Psychiatrie"; i.e., Drug Safety in Psychiatry), which collects data on ADRs from patients treated in psychiatric hospitals in Germany, Austria, and Switzerland. We performed a disproportionality analysis of reports of weight gain (> 10% of baseline body weight) calculating reporting odds ratio (ROR). We compared aripiprazole, carbamazepine, lithium, olanzapine, quetiapine, risperidone, and valproate to lamotrigine. Additional analyses related to different mood stabilizers as reference medication were performed. We also assessed sex and age distributions of weight-gain reports.Results We identified a total of 527 cases of severe drug-induced weight gain representing 7.4% of all severe ADRs. The ROR for lithium was 2.1 (95%CI: 0.9–5.1, p > 0.05), which did not reach statistical significance. Statistically significant disproportionate reporting of weight gain was reported for olanzapine (ROR: 11.5, 95%CI: 4.7–28.3, p < 0.001), quetiapine (ROR: 3.4, 95%CI: 1.3–8.4, p < 0.01), and valproate (ROR: 2.4, 95%CI: 1.1-5.0, p = 0.03) compared to lamotrigine. Severe weight gain was more prevalent in non-elderly (< 65 years) than in elderly patients, with an ROR of 7.6 (p < 0.01) in those treated with lithium, and an ROR of 14.7 (p < 0.01) in those not treated with lithium.Conclusions Our findings suggest that lithium is associated with more reports of severe weight gain than lamotrigine, although this difference did not reach statistical significance. However, lithium use led to fewer reports of severe weight gain than some alternative drugs for long-term medication (olanzapine, quetiapine, and valproate), which is consistent with recent studies. Monitoring of weight gain and metabolic parameters remains essential with lithium and its alternatives.
Coordinate Determination of Domestic SLR Stations Based on Long Arc Orbit Determination Method Using Laser Ranging Data from Lageos1/2 Satellites
Authors: Zhou Chongchong , Wang Junao , Zhong Shiming , Peng Bibo , Zhang Jie , Guo Zhao
Published: July 2023

Satellite Laser Ranging (SLR) technology is one of the main technologies in the field of space geodesy, it has played an extremely important role in laser ranging data application and research. As a commonly used geodynamic satellites, the main contribution of Lageos1/2 is the solution of orbit determination and station coordinates. At present, there are 7 analysis centers of the International Laser Ranging Service (ILRS) to release the precise orbit products for Lageos1/2 satellites. However, there is currently no relevant research on the analysis of the consistency of these orbits. So, the authors would evaluate the accuracies of them, and the results show that the orbital accuracies of Lageos1/2 satellites are 3 ~ 5 cm. SLR is regarded as one of the important input data of the International Terrestrial Reference Frame (ITRF), the analysis center of ILRS provides weekly solutions of station coordinates for ITRF. But, due to the limitation of SLR observation conditions, for example observations can only be made almost exclusively at night and cannot be observed in rainy days, the orbit solution of the seven-day arc may have the problem of less data. Therefore, this paper proposed a method for calculating the station coordinates based on long arc orbit determination, and we adopted the method to solve the station coordinates of five SLR stations in China. The results show that the obtained orbital precision is basically superior to 3.70 cm, and the differences between station coordinates solved by us and the coordinates published by ITRF2014 are basically smaller than 0.013 m, which is consistent with research results domestic and overseas.