bluuebunny/crossref_metadata_2025 huggingface dataset:
Instiutions: the Role of Institutional Quality in Technical Progress in the American Region
Authors: Padilla León , Carrington Sarah J. , Leiva Begoña
Published: March 2024

Technical progress, often measured through changes in total factor productivity (TFP), has been extensively examined within the economic literature. Researchers have proposed that institutional quality is a key driver of TFP. Specifically, while institutions influence business efficiency, financial sector dynamics, and human capital development, they are also critical to providing the conditions that incentivize cooperation and innovation, in turn, augmenting TFP. This study undertakes an examination of the nexus between institutional quality (IQ) and TFP growth across a sample of 20 countries situated in the Americas using annual data from 2002 to 2019. The findings of this study substantiate the premise that enhanced IQ engenders an upswing in the rate of TFP growth, even after controlling for key production inputs, trade integration and macroeconomic conditions. In particular, institutions that promote citizen voice and authority accountability, and nurture a positive perception of the public sector's efficacy, reflecting trust in the state’s competency, are found to be key drivers of productivity growth within the American region.
JEL codes: O47; OO43; E0.
Environmental concentrations of the antidiabetic Metformin cause liver damage in Astyanax lacustris (Lütken, 1875) individuals after chronic exposure
Authors: Paupitz Brennda Ribeiro , Barbieri Pablo Américo , Lupepsa Luara , Fernandes Carlos Alexandre , Portela-Castro Ana Luiza Brito , Borin-Carvalho Luciana Andreia
Published: March 2024

Drugs are emerging contaminants that provide concern when it comes to the adverse effects they can cause on organisms that are not the target of therapeutic action. Because water treatment methods do not entirely remove them, they are found in worrying concentrations in the aquatic environment. Antidiabetic Metformin has been found in the environment worldwide, and studies show it has a potential endocrine disrupting effect. However, more research is needed regarding its impact on bioindicator organisms, such as fish. This work aimed to evaluate the effect of chronic exposure to Metformin in the liver, the organ responsible for the metabolism of xenobiotics, from Astyanax lacustris. The results obtained from histological sections of the organ show that Metformin induced liver damage since the number, size, and composition of hepatocytes have changed. This study demonstrates the need for more research on the damage metformin can cause aquatic life.
Numerical Investigation of Multiphase Flow in 2D Microchannel Using Volume of Fluid Method: A Study on Water Droplet Dynamics
Authors: Sattar Abdul , Bofeng Bai , Manzoor Tareq , Ishtiaq Usama , Mujahid Abu Bakr , Murtaza Kamil , Manzoor Habibullah
Published: March 2024

The study encompasses the visualization and analysis of dynamic water behavior, pressure drop, and saturation interaction under various boundary condition cases. Additionally, the characteristics of the flow in and out of the two-dimensional (2D) channel and the microinjection of water droplets are investigated. The simulations via the Volume of Fluid (VOF) Method include modeling liquid water dynamics with different wall angles in the 2D channel, considering varying air and water inlet velocities. Key parameters such as water volume fraction and pressure drop are thoroughly analyzed. The simulation results demonstrate substantial agreement with the integral characteristics of the process, including dynamics trend, induction time of droplet breakup (saturation phase), and pressure drop. This comprehensive analysis enhances understanding of water droplet dynamics in microchannels and contributes to the optimization of microfluidic devices for a spectrum of applications, from drug delivery to chemical reactions.
Sustainable adsorption of methylene blue (MB) dye using individual and combined ratios of Trigonella foenum-graecum (F) seed galactomannan and Linum usitatissimum (L) seed
Authors: Singh Nikita , Yadav Alpa
Published: March 2024

This study explores the adsorption of methylene blue (MB) dye from aqueous solution using different forms of fenugreek galactomannan and linseed (both individually and in combination) as an adsorbent. Characterization study of adsorbents reveal the involvement of carboxyl, hydroxyl and amine groups in MB adsorption taking place on the amorphous and porous surface of the adsorbent. BET surface area of the adsorbent (F+L) was found to be 394 m2/g. Different parameters including pH, adsorbent dose, adsorbate concentration, adsorption time and temperature were studied. Results of the study shows 86.62, 86.94, 88.04, 88.24, 88.56 and 89.09% of MB dye adsorption with F, L, F + L (1:1), F + L (1:2), F + L (2:1) and F + L (2:2) under optimized conditions. Maximum adsorption take place at pH 12, i.e., highly basic medium. Isothermal study shows the fitness of the experimental data to Langmuir isotherm model. Kinetic modeling shows that both physical and chemical interactions are involved in dye adsorption. Further, thermodynamic study confirms the spontaneity, endothermicity and feasibility of the process. Overall, current research involves the use of low-cost raw material for MB dye removal that aids in waste management and in promoting sustainability.
Ni Charlie Hebdo ni Francisco I. Sí Voltaire, Larry Flynt o Mr. Bean. Reflexiones sobre las libertades de expresión e información en la era digital
Authors: Cavero Safra Enrique
Published: March 2024

A través del análisis de distintas figuras y sucesos históricos de los últimos años, el autor explora los dificultosos límites de los derechos de expresión e información. Así, formula conclusiones sobre un concepto moderno de libertades informativas que cobran especial relevancia con el arribo de nuevas tecnologías en el siglo XXI.
PRÁTICAS ÁGEIS NO SETOR PÚBLICO
Authors: Guimarães Luisa Silva , Toledo Giovanna Lunardi , Rodrigues Karen Christine Dias Gomes , Nascimento Silva Patrícia
Published: March 2024

Este relato de experiência visa analisar as práticas ágeis adotadas na articulação institucional para implementação do Acordo Judicial de Reparação de Brumadinho, elucidando os desafios e soluções adotadas para promover o avanço contínuo das iniciativas previstas. Por meio da revisão teórica dos conceitos de métodos ágeis – especificamente do framework Scrum, e da contextualização do Acordo Judicial celebrado, foi realizada a observação do processo de consolidação da estrutura vigente, com ênfase aos Anexos I.3 e I.4. Com uma estrutura de governança simplificada, o Acordo pretendeu garantir agilidade e efetividade da tomada de decisão e, consequentemente, de implementação das medidas de reparação, promovendo também o envolvimento de representantes de várias pastas responsáveis pelo manejo dos efeitos do evento. Por sua vez, a atuação conjunta dessas instituições tem demandado a criação de fluxos e procedimentos inovadores, que permitam a cooperação e coordenação, sem prejuízo de suas competências legais e de sua autonomia. O framework Scrum se mostrou aplicável em parte significativa desse “projeto”, sendo possível sua adaptação no contexto analisado. No entanto, para uma maior efetividade, o método precisa ser cultuado e difundido para todos os atores envolvidos. Apesar dos encaminhamentos e resultados alcançados, identificam-se ainda desafios diante desta dinâmica, visando garantir o pleno envolvimento e participação de todos os atores no processo de discussão para as deliberações e tomada de decisão. Para trabalhos futuros, sugere-se expandir a análise das práticas do Scrum no Acordo e também nos projetos relacionados, em especial nos projetos destinados às Comunidades e Povos Tradicionais.
A Review on the Use of Modern Computational Methods in Alzheimer’s
Disease-Detection and Prediction
Authors: De Arka , Mishra Tusar Kanti , Saraf Sameeksha , Tripathy Balakrushna , Reddy Shiva Shankar
Published: March 2024

Discoveries in the field of medical sciences are blooming rapidly at the cost of voluminous
efforts. Presently, multidisciplinary research activities have been especially contributing to
catering cutting-edge solutions to critical problems in the domain of medical sciences. The modern
age computing resources have proved to be a boon in this context. Effortless solutions have become
a reality, and thus, the real beneficiary patients are able to enjoy improved lives. One of the
most emerging problems in this context is Alzheimer’s disease, an incurable neurological disorder.
For this, early diagnosis is made possible with benchmark computing tools and schemes. These
benchmark schemes are the results of novel research contributions being made intermittently
in the timeline. In this review, an attempt is made to explore all such contributions in the past few
decades. A systematic review is made by categorizing these contributions into three folds, namely,
First, Second, and Third Generations. However, priority is given to the latest ones as a handful of
literature reviews are already available for the classical ones. Key contributions are discussed
vividly. The objectives set for this review are to bring forth the latest discoveries in computing
methodologies, especially those dedicated to the diagnosis of Alzheimer’s disease. A detailed timeline
of the contributions is also made available. Performance plots for certain key contributions
are also presented for better graphical understanding.
Risk of Subsequent Primary Cancers Among Adult-Onset 5-Year Cancer Survivors in South Korea: Retrospective Cohort Study
Authors: Choi Yoon Young , Lee Myeongjee , Kim Eun Hwa , Lee Jae Eun , Jung Inkyung , Cheong Jae-Ho
Published: March 2024

Background

The number of cancer survivors who develop subsequent primary cancers (SPCs) is expected to increase.

Objective

We evaluated the overall and cancer type–specific risks of SPCs among adult-onset cancer survivors by first primary cancer (FPC) types considering sex and age.

Methods

We conducted a retrospective cohort study using the Health Insurance Review and Assessment database of South Korea including 5-year cancer survivors diagnosed with an FPC in 2009 to 2010 and followed them until December 31, 2019. We measured the SPC incidence per 10,000 person-years and the standardized incidence ratio (SIR) compared with the incidence expected in the general population.

Results

Among 266,241 survivors (mean age at FPC: 55.7 years; 149,352/266,241, 56.1% women), 7348 SPCs occurred during 1,003,008 person-years of follow-up (median 4.3 years), representing a 26% lower risk of developing SPCs (SIR 0.74, 95% CI 0.72-0.76). Overall, men with 14 of the 20 FPC types had a significantly lower risk of developing any SPCs; women with 7 of the 21 FPC types had a significantly lower risk of developing any SPCs. The risk of developing any SPC type differed by age; the risk was 28% higher in young (<40 years) cancer survivors (SIR 1.28, 95% CI 1.16-1.42; incidence: 30 per 10,000 person-years) and 27% lower in middle-aged and older (≥40 years) cancer survivors (SIR 0.73, 95% CI 0.71-0.74; incidence: 80 per 10,000 person-years) compared with the age-corresponding general population. The most common types of FPCs were mainly observed as SPCs in cancer survivors, with lung (21.6%) and prostate (15.2%) cancers in men and breast (18.9%) and lung (12.2%) cancers in women. The risks of brain cancer in colorectal cancer survivors, lung cancer in laryngeal cancer survivors, and both kidney cancer and leukemia in thyroid cancer survivors were significantly higher for both sexes. Other high-risk SPCs varied by FPC type and sex. Strong positive associations among smoking-related cancers, such as laryngeal, head and neck, lung, and esophageal cancers, were observed. Substantial variation existed in the associations between specific types of FPC and specific types of SPC risk, which may be linked to hereditary cancer syndrome: for women, the risks of ovarian cancer for breast cancer survivors and uterus cancers for colorectal cancer survivors, and for men, the risk of pancreas cancer for kidney cancer survivors.

Conclusions

The varying risk for SPCs by age, sex, and FPC types in cancer survivors implies the necessity for tailored prevention and screening programs targeting cancer survivors. Lifestyle modifications, such as smoking cessation, are essential to reduce the risk of SPCs in cancer survivors. In addition, genetic testing, along with proactive cancer screening and prevention strategies, should be implemented for young cancer survivors because of their elevated risk of developing SPCs.
Improving Behavioral-Based Safety Training in Using Verbal Commands Through a Theory-Driven and Feedback-Based Nonimmersive Virtual Reality Game: Development and Usability Study (Preprint)
Authors: Atagbuzia Chukwudiebube , Ng Ean H , Natarajan Ganapathy
Published: March 2024

BACKGROUND

The construction, chemical, aviation, medical, and health care industries have used serious games for safety training. To our knowledge, serious games have not been developed focusing on behavioral change to improve safety through the use of verbal commands and instilling players with heightened awareness of their spatial proximity to other people in their surroundings.

OBJECTIVE

We aimed to develop a theory-driven serious game for improving safety behavior using verbal commands and validate the implementation of the theoretical frameworks used for game development. The game developed, KitchenSpeak, was a first-person character (FPC) game where users respond to in-game prompts to use loud verbal commands when they are approaching another employee’s blind spot.

METHODS

In addition to using the SERES framework in guiding the general game design and development, and the Reflection, Engagement, Choice, Information, Play, Exposition (RECIPE) framework to inform the design of the game mechanics, we also applied gestalt laws of perception for graphic design to guide the design of the game’s user interface. We conducted 2 evaluative tests (alpha and beta) to collect end user and stakeholder feedback on the implementation of the theoretical frameworks, as well as to collect relevant information for full-scale implementation and a future validation study.

RESULTS

The alpha and beta tests had 8 and 40 participants, respectively. The alpha test results revealed that the theoretical frameworks were adequately applied; however, suggestions were also made to modify and improve the game. The beta test results suggested further improvements for the game design and found no differences in the perception of ease of play between participants with and without previous FPC gaming experience (P=.47; Kruskal-Wallis). Results suggested that the game met its design and theoretical requirements, and it would be easily playable by all players regardless of their previous experience in FPC games.

CONCLUSIONS

A theory-driven and evidence-based FPC game titled KitchenSpeak was developed to teach the use of kitchen-speak terms in commercial kitchens. Evaluative tests were conducted to validate the implementation of the theoretical frameworks. Our main contributions are creating and validating game-based training to improve behavioral-based safety in the workplace and the incorporation of gestalt laws of perception for graphic design in the game’s user interface.
Capability of GPT-4V(ision) in the Japanese National Medical Licensing Examination: Evaluation Study (Preprint)
Authors: Nakao Takahiro , Miki Soichiro , Nakamura Yuta , Kikuchi Tomohiro , Nomura Yukihiro , Hanaoka Shouhei , Yoshikawa Takeharu , Abe Osamu
Published: March 2024

BACKGROUND

Previous research applying large language models (LLMs) to medicine was focused on text-based information. Recently, multimodal variants of LLMs acquired the capability of recognizing images.

OBJECTIVE

We aim to evaluate the image recognition capability of generative pretrained transformer (GPT)-4V, a recent multimodal LLM developed by OpenAI, in the medical field by testing how visual information affects its performance to answer questions in the 117th Japanese National Medical Licensing Examination.

METHODS

We focused on 108 questions that had 1 or more images as part of a question and presented GPT-4V with the same questions under two conditions: (1) with both the question text and associated images and (2) with the question text only. We then compared the difference in accuracy between the 2 conditions using the exact McNemar test.

RESULTS

Among the 108 questions with images, GPT-4V’s accuracy was 68% (73/108) when presented with images and 72% (78/108) when presented without images (P=.36). For the 2 question categories, clinical and general, the accuracies with and those without images were 71% (70/98) versus 78% (76/98; P=.21) and 30% (3/10) versus 20% (2/10; P≥.99), respectively.

CONCLUSIONS

The additional information from the images did not significantly improve the performance of GPT-4V in the Japanese National Medical Licensing Examination.

CLINICALTRIAL
Correction: Using Conversational AI to Facilitate Mental Health Assessments and Improve Clinical Efficiency Within Psychotherapy Services: Real-World Observational Study (Preprint)
Authors: Rollwage Max , Habicht Johanna , Juechems Keno , Carrington Ben , Viswanathan Sruthi , Stylianou Mona , Hauser Tobias U , Harper Ross
Published: March 2024

UNSTRUCTURED
The Dark Web: Challenges and Countermeasures in Combating Cybercrime
Authors: Shaikh Faisal
Published: March 2024

Abstract: This research paper delves into the complexities surrounding "The Dark Web: Challenges and Countermeasures in Combating Cybercrime." As the Dark Web continues to be a breeding ground for illicit activities, this study examines the multifaceted challenges faced by law enforcement. Factors such as limited visibility, encryption technologies, and jurisdictional obstacles hinder effective intervention. In exploring countermeasures, the paper evaluates technological advancements and legal frameworks deployed to mitigate cyber threats. Ethical considerations are scrutinized in striking a balance between privacy rights and the imperative to combat criminal activities. The abstract encapsulates an analysis of these challenges and proposes insights into the evolving landscape of cybercrime prevention on the Dark Web
Atmosfera wychowawcza jako podstawa ochrony dynamicznej w jednostce penitencjarnej
Authors: Poklek Robert
Published: March 2024

Oddziaływania penitencjarne mające na celu pozytywną aktywność więźniów w kierunku ich wewnętrznej przemiany (readaptacji) a następnie przyjęcie przez zewnętrzne – wolnościowe otoczenie (reintegracja społeczna), muszą odbywać się w odpowiednim środowisku wychowawczym, gwarantującym atmosferę sprzyjającą realizacji nie tylko celów izolacyjno -dyscyplinujących, ale przede wszystkim wychowawczo-resocjalizacyjnych. Ochrona dynamiczna to swoista filozofia budowania bezpieczeństwa w więzieniu opartego na podmiotowychrelacjach personelu z więźniami i aktywnym zapobieganiu występowaniu zagrożeń, zanim staną się groźne i będą eskalować. W artykule poruszono problematykę możliwości i ograniczeń organizacyjnych i mentalnych wpływających na wdrożenie ochrony dynamicznej jako praktyki kształtowania właściwej atmosfery wychowawczej, przy zachowaniu warunków bezpieczeństwa w jednostkach penitencjarnych.
The Development of Liveworksheet-Assisted Problem Based Learning Teaching Materials to Improve Students' Learning Outcomes on Social Arithmetic
Authors: Ramdani Rasya Asri , Amelia Risma
Published: March 2024

This study intends to determine the feasibility and practicality of worksheets for students of Social Arithmetic material using the Liveworksheets-assisted Problem Based Learning learning model. The development model used is the 4D method which is limited to the third step which includes: define, design and develompment stages. Feasibility test data and practicality of LKPD were collected through observation and questionnaires. The feasibility of LKPD is analyzed based on the results of validation by experts and the practicality of LKPD seen from student questionnaire responses. The subjects of this study were 5 students on a small scale and 30 students on a broad scale. The results of this study show that the LKPD tested is very feasible and very practical to use for learning. This is seen based on the results of validation by experts who get an average of 95% with very valid categories and the practicality of LKPD taken from student response questionnaires with a percentage of 87.56% on a small scale and 88.33% on a broad scale. This shows that LKPD uses the Liveworksheets-assisted Problem Based Learning learning model on Social Arithmetic material is very valid and practical to use.
The Development of Quizziz Assisted Think-Talk-Write Approach Teaching Materials to Improve Students Problem Solving Skills on Social Arithmetic
Authors: Bahari Abdul Ghofur , Setiawan Wahyu
Published: March 2024

The development of this research was driven by the low academic achievement of high school students in the field of social arithmetic. This study aims to develop teaching materials through a test-assisted think-speak-write approach to improve problem-solving skills. The type of research used is development research with the 4D development model (Define, Design, Develop, Dissemination). Research using this model is limited to stage 3 (define, design, develop) due to limited research time. The object of this study was students of class VII at Al-Fatih KBB integrated college with data analysis techniques using descriptive qualitative techniques. Data was collected and then analyzed using Microsoft Excel. Results shows that the feasibility of teaching materials can be seen from the results of the evaluator's assessment, small-scale tests and large-scale tests. At 91% and 95% in the "Very Decent" category. Thus the student response to teaching materials has developed with a percentage of 82% and 84% are in the "Very Realistic" category. The limitations encountered in the development of educational materials are supported by the quizizz application. Study time is limited and school facilities are very inadequate to carry out learning in the classroom. Learning by using teaching materials media assisted by the quizizz application can be used and can be developed by the teacher on ongoing basis with different materials and themes.
The Effect of Maternal Under Nutrition on Adverse Birth Outcomes among Women Who Attend Antenatal Care in Gedeo Zone Public Hospitals, Southern Ethiopia, Prospective Follow-Up Study
Authors: Deyaso Zerihun , Temesgen Tesfaye , Mahamed Abbas Ahimed , Bekele Etaferahu , Zemeskel Addisu Getnet
Published: March 2024

Objective: The aim of this study was to assess the effect of
maternal undernutrition on adverse birth outcomes in Gedeo zone public
hospitals. Design: A prospective cohort study was employed
Setting: Gedeo zone public hospitals Population:
Antenatal care women Method: A modified Poisson regression
model with robust standard errors was used to determine relative risk
and the statistical association was declared at the p-value ≤0.05.
Main outcome measures: Risk of obstetrics and birth outcomes
from undernutrition during pregnancy. Result: The incidence of
the adverse obstetrics outcomes among women with undernourishment were
hypertensive disorder during pregnancy 22.78%, antepartum haemorrhage
6.33%, obstructed labor 4.64%, premature rupture of the membrane
8.0%, preterm labor 19.83%, instrumental vaginal delivery 5.49%,
operative delivery 18.14%, postpartum haemorrhage 18.14%, and sepsis
or chorioaminitis 11.9%. Similarly the incidence of stillbirth
34(4.71%), intrauterine growth restriction (IUGR) 72(10%), small for
gestational age (SGA) 70(9.7%), low birth weight (<2500g) and
preterm birth 91(12.62%) and 118 (16.36%), low first minute Apgar
score (<7) 230(32.0%) and low fifth minute Apgar score was
and 130 (18.0%), birth asphyxia 136 (18.86%), neonatal intensive care
unit (NICU) 108 (15.0%), neonatal death of 26.3/1000 live birth. The
risk of hypertensive disorder during pregnancy (HDDP) was (aRR)=4.07,
95%CI: 2.53-6.55), antepartum haemorrhage (APH) (aRR=5.0,
95%CI:2.08-12.72), preterm labor (aRR=1.8, 95%CI: 1.23-2.62),
operative delivery (aRR=1.24,95%CI;0.87-1.78), postpartum haemorrhage
(aRR=3.02, 95%CI: 1.91-4.79), and sepsis/chrioaminitis (aRR=3.55,
95%CI: 1.83- 6.89) times higher compared to women without
undernourishment. The risk of intrauterine growth restriction (IUGR)
aRR=4.05 times (95%CI; 2.87-8.47), small for gestational age (SGA)
aRR=2.49 times (95%CI; 1.55-4.0), birth asphyxia aRR=2.72 times
(95%CI; 2.0-3.0), and admission to neonatal intensive care unit (NICU)
aRR=4.29times (95%CI; 2.94-6.24) higher for undernourished women than
normally nourished women. Conclusion: According to this study,
the overall incidence of adverse birth outcomes was high. The fetus born
from an undernourished woman has a higher risk for stillbirth 1.92
times, intrauterine growth restriction 4.05 times, small for gestational
age 2.49 times, birth asphyxia 2.72 times, admission to NICU 4.29 times,
and early neonatal death 3.79 times.
Comparison of the Quality of Soybean Meal and Oil by Soybean Production Origin
Authors: Liu Huazhen , Gishini Mohammad , Pope Micah , Doehring Todd , Kachroo Pradeep , Hildebrand David
Published: March 2024

Previous reports indicate variable soybean quality parameters exported
from different geographic regions. This review compares soybean and
soybean co-products grown under diverse environmental conditions. While
numerous studies have been conducted on whole soybean and soybean meal
(SBM) composition by origin, similar analysis of soybean oil is lacking.
This review has two objectives: 1) summarize soybean and SBM quality by
origin using a meta-analysis approach, and 2) analyze collected crude
degummed soybean oil samples that originate from the US, Brazil and
Argentina for key quality attributes. Soybeans from Brazil have higher
levels of protein (P < 0.05) than US soybeans, but US soybeans
have lower heat damage (P < 0.05) and total damage (P
< 0.05) than soybeans from Brazil. US and Brazil SBM have
higher crude protein (CP) (P < 0.05) than SBM from Argentina.
At equal CP content, US SBM had less fiber (P < 0.0001), more
sucrose (P < 0.0001) and lysine (P < 0.0001) and
better protein quality than South American SBMs. Methionine, threonine,
and cysteine levels were similar in soybean protein from US and
Argentina and higher than that in soybean protein from Brazil. Crude
degummed soybean oil from Brazil had more (P < 0.05) free
fatty acids, neutral oil loss, phosphorus, calcium and magnesium than
crude degummed soybean oil from the US or Argentina. Our analysis
suggests that environmental conditions under which soybeans are grown,
stored, and handled can have a large impact on chemical composition and
nutrient quality of soybean meal and soybean oil.
Deep Learning Methods for Protein Function Prediction
Authors: Boadu Frimpong , Lee Ahhyun , Cheng Jianlin
Published: March 2024

Predicting protein function from protein sequence, structure,
interaction, and other relevant information is important for generating
hypotheses for biological experiments and studying biological systems,
and therefore has been a major challenge in protein bioinformatics.
Numerous computational methods had been developed to advance protein
function prediction gradually in the last two decades. Particularly, in
the recent years, leveraging the revolutionary advances in artificial
intelligence (AI), more and more deep learning methods have been
developed to improve protein function prediction at a faster pace. Here,
we provide an in-depth review of the recent developments of deep
learning methods for protein function prediction. We summarize the
significant advances in the field, identify several remaining major
challenges to be tackled, and suggest some potential directions to
explore. The data sources and evaluation metrics widely used in protein
function prediction are also discussed to assist the machine learning,
AI, and bioinformatics communities to develop more cutting-edge methods
to advance protein function prediction.
Relationship between serum AGE precursor levels, oxidative stress, and quality of life in patients receiving hemodialysis
Authors: Aksoy Tulay , Ozer Zulfunaz , Yaman §mustafa
Published: March 2024

Introduction/Objective. The aim of this study was to determine the relationship between serum advanced glycation end product (AGE) precursors, oxidative stress levels, and quality of life in hemodialysis patients. Methods. A descriptive form and the Kidney Disease Quality of Life Form (KDQOL-36) were used in the study. Serum levels of AGE precursors [methylglyoxal (MGO) and glyoxal (GO)] and oxidative stress [malondialdehyde (MDA)] were determined in blood samples taken from the patients. Results. The KDQOL-36 subscale scores were 71.65 ? 17.76 for the symptoms/problems list, 66.35 ? 19.06 for the effect of kidney disease, 40.6 ? 24.01 for the kidney disease burden, 41.6 ? 9.83 SF-12 for physical health, and 37.83 ? 9.69 for SF-12 mental health. The serum levels were 3.96 ? 1.01 ?mol/L for MDA, 1029.87 ? 314.43 ng/mL for GO, and 115.2 ? 75.54 ng/mL for MGO. A positive and significant correlation was detected between serum MGO and GO (r = .285, p < 0.01) and MDA (r = 0.284, p < 0.01). A positive correlation was noted between serum MDA and GO (r = 1,000, p < 0.05) and a negative correlation with kidney disease burden (r = -0.205, p < 0.05). A negative and significant correlation was detected between GO and kidney disease burden (r = -0.204, p < 0.05). Conclusion. Serum MGO, GO, and MDA levels were high in patients undergoing hemodialysis. High serum MDA levels are associated with high serum GO and MGO levels. High serum levels of MDA and GO had a negative impact on the quality of life of hemodialysis patients.
Efecto de las condiciones de curado en el desempeño mecánico de los cementos geopoliméricos: una revisión
Authors: Bedoya-Henao Carlos Andrés , Tobón Jorge I. , Hoyos-Montilla Ary A.
Published: March 2024

Teniendo en cuenta el potencial de los cementos geopoliméricos como una alternativa para sustituir parcialmente al cemento Portland, este artículo presenta el análisis del efecto que tienen las condiciones de curado de los cementos geopoliméricos sobre su desempeño mecánico. Las variables evaluadas durante el proceso de curado fueron tiempo, humedad y temperatura. Además, se describe el comportamiento de estas variables de acuerdo con los métodos de curado que han sido estudiados y evaluados hasta el momento en los cementos geopoliméricos con base de ceniza volante. Para llevar a cabo la revisión bibliográfica fue usado Scopus como herramienta principal de búsqueda, a partir de la palabra clave “cementos geopoliméricos”. Se identificaron más de 90 documentos relevantes tras aplicar filtros específicos y revisar sus resúmenes. Finalmente, se realizó una lectura y análisis detallado de los datos bibliográficos, que aportaron información relevante para el tema de estudio. Los procedimientos publicados muestran que no hay unanimidad para definir el mejor método de curado para este tipo de material; sin embargo, las condiciones más aceptadas para el desarrollo de mayores resistencias a la compresión son temperaturas entre 60 y 80 °C, con humedad controlada (sellado), durante un periodo de 4 a 12 horas. En general, esta revisión sirve como una guía para proponer, estudiar y aplicar diferentes procesos de curado en cementos geopoliméricos con base de ceniza volante, buscando optimizar su desempeño mecánico.
Positive Factors Facilitating Collaboration Between Early Childhood Education and Care Institutions, and Multilingual Parents – A Protocol for a Systematic Review and Thematic Synthesis
Authors: Fredriksson Maria , Hoel Trude , Jernes Margrethe
Published: March 2024

This protocol presents the planned and upcoming work for a systematic review of the topic positive factors facilitating cooperation between early childhood education and care (ECEC) institutions, and multilingual parents. The number of children with a foreign background, both in Scandinavia and internationally, has increased during recent decades. These children are often exposed to more than one language on a daily basis. Earlier research has established that collaboration between ECEC institutions and parents is a vital factor in children’s development, learning, and school success. This is especially the case for multilingual children with a foreign background. This protocol discusses research-based knowledge in relation to this collaboration, and identifies a knowledge gap regarding up-to-date research on the positive factors enabling collaboration between ECEC institutions and multilingual parents. The aim of the planned systematic review is to contribute a scientifically based overview of knowledge about the positive factors facilitating collaboration between ECEC institutions and multilingual parents. The choice of methods for conducting this systematic review is stated and described in the presented protocol.
Pengenalan Literasi Bahasa Inggris dengan Digital Storytelling Berbasis STEAM Bagi Anak Usia Dini
Authors: Yulian Ryani , Maulidha Eka Putri
Published: March 2024

Pengenalan Bahasa Inggris menjadi relevan untuk pendidikan anak usia dini seperti melalui pembelajaran multimodal digital storytelling. Kombinasi digital storytelling yang melibatkan unsur cerita naratif dan penguatan dalam platform multimodal dengan tema Science, Technology, Engineering, Arts, Mathematics (STEAM) mampu membantu anak-anak memahami dan mengingat konten terkait ilmu pengetahuan, teknologi, dan seni. Hal ini sejalan dengan analisis permasalahan melalui observasi dan wawancara dengan Kepala Sekolah. Hasil analisis menunjukkan bahwa sekolah masih belum memiliki model pembelajaran Bahasa Inggris dengan pendekatan STEAM. Kegiatan pengabdian ini diberikan kepada PAUD KB TK LAB Model Universitas Muhammadiyah Pontianak. Pengabdian kepada masyarakat ini diberikan kepada sekolah dengan memberikan Model Digital Storytelling berbasis STEAM dengan pengajaran langsung kepada anak usia dini. Kegiatan pengabdian ini bertujuan untuk melengkapi model pembelajaran tematik integratif berbasis digital storytelling dengn tema STEAM. Metode yang digunakan yaitu play-based learning dengan explicit instruction dengan media PowerPoint macro. Hasil kegiatan menunjukkan siswa tertarik belajar sambil bermain secara holistik yang mendayagunakan pembelajaran audio, visual, dan kinestetik seperti melafalkan bunyi, menirukan suara, membedakan visual warna, belajar secara tematik, dan bergerak secara aktif. Siswa juga terlibat dalam kegiatan menempel kolase pasir untuk pengembangan kreativitas dan keterampilan motorik halus.
Legal Education on Child Protection: Efforts to Reduce the Rate of Dating Violence among Adolescents
Authors: Ali Nuraliah , Farina Thea , Umar Mardan
Published: March 2024

The escalation of violence among vulnerable child groups highlights the pivotal role of knowledge in addressing adversities. This study aims to utilize a Community Service Activity as external educational support to enhance teenagers' comprehension of dating violence and its legal aspects. Legal seminars engaged 88 adolescents from public and private schools in Palangka Raya city. Employing a pretest-posttest design, the intervention proved effective. Results showed a notable 63.63% improvement in adolescents' awareness of legal implications and understanding of potential criminal sanctions. However, marginal progress of 4.5% was observed in refining the definition aspect, indicating a basic understanding of unacceptable behaviors in dating relationships. The success of this initiative is evident in significantly enhancing adolescents' understanding of dating violence and its legal implications. These findings stress the need for tailored educational interventions to strengthen adolescents' legal awareness regarding dating violence. Implications suggest nuanced strategies to fortify understanding of legal protections within relationships, fostering safer environments for vulnerable groups.
Transactional Analysis Counseling to Improve Intercultural Communication of Tourism Vocational Students
Authors: Putu Ari Dharmayanti  , Adi Atmoko  , Blasius Boli Lassan  , Muslihati  , Putu Sri Lestari
Published: March 2024

Schools had never implemented special techniques in the implementation of Guidance and Counseling to develop students' intercultural communication at school. These problems cause failure in the communication process which can result in worsening social relations between students. The aim of this research is to analyze the differences in intercultural communication between Tourism Vocational School students before and after the transactional analysis counseling intervention. The research design used is a pretest posttest group design. The sampling technique in this research is purposive sampling, namely sampling based on the researcher's judgment. This research uses two types of instruments, namely: (1) transactional analysis counseling module treatment materials, and (2) data collection instruments in the form of an intercultural communication competency scale. The data collected in this research is then analyzed using the non-parametric Wilcoxon statistical test. To answer the hypothesis in this research, it can be seen from the results of the pretest and posttest hypothesis test table which shows a significance figure of 0.028 which means less than 0.05 so that Ho is rejected, so the hypothesis is accepted, namely that there is a difference in intercultural communication between Tourism Vocational School students before the transactional analysis counseling intervention and after intervention in the experimental group.
Mathematical analysis of a spatiotemporal dynamics of a delayed IS-LM model in economics
Authors:   Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca, Elkarmouchi M. , Lasfar S. ,   Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca, Hattaf K. ,   Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca; Equipe de Recherche en Modélisation et Enseignement des Mathématiques (ERMEM), Centre Régional des Métiers de l'Education et de la Formation (CRMEF), Yousfi N. ,   Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M'Sick, Hassan II University of Casablanca
Published: March 2024

The purpose of this research is to suggest and analyze a spatiotemporal of an IS-LM model with two delays, interest rate, liquidity preference and general investment function. The first delay into the proposed model refers to the time delay between the decision of investment and his implementation. However, the second one represents the delay in investment production. The well posedness of the model is proved. The stability analysis and the existence of Hopf bifurcation are obtained. Furthermore, numerical examples that confirm the analytical results are shown.
Analisis Laporan Keuangan Dana Desa Pada Kampung Sri Sawahan Kecamatan Punggur
Authors: Nani Septiana  , Deny Edy Widodo  , Muhammad Rafli
Published: March 2024

Financial statements are information that describes the condition of a company ororganization which will then become information that describes the performance of acompany or organization. This research was conducted to analyze the financial reports ofvillage funds with the aim of assessing the performance of village government apparatususing village income and expenditure reports in the 2020 and 2021 fiscal years. In this studythe ratios used were the regional independence ratio and the regional spending efficiencyratio. This study uses a descriptive method with a quantitative approach. The object of thisresearch is Sri Sawahan Village, Punggur District. The data in this study used villagerevenue and expenditure budget data (APBDes) in the 2020 and 2021 fiscal years. Theresults of the research are that the performance of the government of Kampung Sri Sawahanin terms of regional independence ratio in 2020 and 2021 is very low. And the regionalspending efficiency ratio also shows less efficient results.
Pemenuhan Hak Asasi Manusia untuk Pendidikan Pengungsi Anak di Indonesia
Authors: Asyia Arifah Di'Faeni Nurul , Sinurat Gabriela Dameni Natalia , Nulhaqim Soni Akhmad
Published: March 2024

Indonesia merupakan salah satu negara yang belum meratifikasi Perjanjian Konvensi Pengungsi dan Protokol Pengungsi. Meski demikian, Indonesia tetap menerima pengungsi secara Internasional dan melakukan pemenuhan hak-hak pengungsi, termasuk juga pemenuhan hak pendidikan bagi pengungsi anak. Pentingnya pemenuhan hak pendidikan pada anak juga dipertegas pada UU Nomor 20 Tahun 2003 pasal 1 ayat (14), bahwa setiap anak yang ada di dunia ini berhak mendapatkan hak pendidikan yang dimilikinya sejak lahir dengan bertujuan untuk membantu pertumbuhan serta perkembangan jasmani dan rohani anak agar memiliki kesiapan dalam memasuki pendidikan dijenjang berikutnya. Dalam penulisan artikel ini, kami menggunakan metode studi literatur dengan mengumpulkan sekitar 12 artikel atau bahan bacaan yang sudah ada sebelumnya dan menjadikan hal tersebut sebagai acuan. Hasil penelitian menemukan bahwa masih terdapat kendala dan permasalahan dalam pemenuhan hak pendidikan pengungsi anak di Indonesia, seperti masalah komunikasi hingga masalah administrasi. Namun, Indonesia tetap berupaya untuk memaksimalkan pemenuhan hak tersebut. Tujuan dari penelitian ini adalah untuk melihat kondisi pemenuhan hak pendidikan pengungsi anak di Indonesia serta peran pekerja sosial dalam upaya memenuhi hak tersebut.
Multidimensional tooth movement boundaries in the extended aesthetic zone: a cone-beam computed tomography study
Authors: Zhang Ruoyan , Li Linyi , Lu Zhiyao , Song Zhixin , Fan Xinyue , Xu Jianing , Zhang Xu , Jin Zuolin , Ma Yanning
Published: March 2024

Purpose

To establish tooth movement boundaries in four directions by a novel morphometric analysis of alveolar bone using conebeam computed tomography (CBCT) images. The aim was to assist clinicians in minimising the occurrence of bone fenestration and dehiscence, thereby facilitating safe and efficient orthodontic treatment.

Methods

CBCT images of 123 male volunteers comprising 55 individuals with hypodivergent vertical skeletal patterns and 68 individuals with normodivergent vertical skeletal patterns and normal occlusions but without a history of previous orthodontic treatment, were analysed. The mesiodistal and labiolingual alveolar bone height (ABH) as well as the labiolingual cancellous bone thickness (CBT) were measured in relation to the maxillary and mandibular anterior teeth and premolars. These parameters were subsequently compared between the different vertical skeletal patterns.

Results

Teeth within the extended aesthetic zone exhibited a limited range of safe movement on the labial aspect across all three root aspects, with 97.6% of the upper lateral incisors and 98.4% of the lower lateral incisors positioned against the labial cortical plate (<0.5 mm). The lingual aspects had significantly more space for tooth movement compared with the labial aspects (P < 0.05). The ABH was significantly greater in the hypodivergent group than the normodivergent group involving particular teeth and sites in the maxilla (P < 0.05), while no significant difference was noted in the mandible. The hypodivergent group also exhibited thicker cancellous bone on most labial and some lingual aspects.

Conclusions

The findings provided the average tooth movement range in the horizontal and vertical directions within the extended aesthetic zone in male individuals presenting with a normal occlusion. It was concluded that a hypodivergent growth pattern may have a relatively large range of safe tooth movement in the sagittal and vertical directions.
Misdiagnosis of Tracher-Collins Syndrome Initially Attributed to Drug Teratogenicity: A Moroccan Case Report
Authors: Lamzouri A , EL Rherbi A , Ratbi I , Laarabi FZ , Chahboune R , Elalaoui SC , Hamdaoui H , Bencheikh RS , Sefiani A
Published: March 2024

Background

Treacher Collins syndrome (TCS) is a rare congenital disorder of craniofacial development characterized by numerous developmental anomalies that are restricted to the head and neck. Most TCS cases are inherited in an autosomal dominant manner. The diagnosis of TCS relies on clinical and radiographic findings. The four genes involved in TCS are TCOF1, POLR1D, POLR1C, and POLR1B.

Case presentation

In this report, we present the case of a 7-year-old Moroccan boy who exhibited distinctive dysmorphic features, including coloboma and zygomatic bone hypoplasia. Upon genetic analysis, a mutation in the TCOF1 gene was identified, conclusively confirming the presence of Treacher Collins Syndrome. It is worthy that the correct etiological diagnosis was significantly delayed due to the initial misperception that the observed malformation syndrome was a result of drug teratogenicity.

Conclusions

This case highlights the importance of seeking pharmacovigilance advice if any adverse event occurs following medication use. Furthermore, requesting a genetic consultation to establish a confirmed etiological diagnosis for any malformation syndrome can significantly reduce the protracted social and psychological suffering that patients and their families may endure.
Automated Parkinson's Disease Detection: A Review of Techniques, Datasets, Modalities, and Open Challenges
Authors: Zadoo Sheerin , Singh Yashwant , Singh Pradeep Kumar
Published: March 2024

Parkinson's disease (PsD) is a prevalent neurodegenerative malady, which keeps intensifying with age. It is acquired by the progressive demise of the dopaminergic neurons existing in the substantia nigra pars compacta region of the human brain. In the absence of a single accurate test, and due to the dependency on the doctors, intensive research is being carried out to automate the early disease detection and predict disease severity also. In this study, a detailed review of various artificial intelligence (AI) models applied to different datasets across different modalities has been presented. The emotional intelligence (EI) modality, which can be used for the early detection and can help in maintaining a comfortable lifestyle, has been identified. EI is a predominant, emerging technology that can be used to detect PsD at the initial stages and to enhance the socialization of the PsD patients and their attendants. Challenges and possibilities that can assist in bridging the differences between the fast-growing technologies meant to detect PsD and the actual implementation of the automated PsD detection model are presented in this research. This review highlights the prominence of using the support vector machine (SVM) classifier in achieving an accuracy of about 99% in many modalities such as magnetic resonance imaging (MRI), speech, and electroencephalogram (EEG). A 100% accuracy is achieved in the EEG and handwriting modality using convolutional neural network (CNN) and optimized crow search algorithm (OCSA), respectively. Also, an accuracy of 95% is achieved in PsD progression detection using Bagged Tree, artificial neural network (ANN), and SVM. The maximum accuracy of 99% is attained using K-nearest Neighbors (KNN) and Naïve Bayes classifiers on EEG signals using EI. The most widely used dataset is identified as the Parkinson's Progression Markers Initiative (PPMI) database.