bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal Assessment of Nutritional Status in Older Subjects with the Chronic Obstructive Pulmonary Disease—A Comparison of Three Screening Tools Used in the GLIM Diagnostic Algorithm
Authors: Kaluźniak-Szymanowska Aleksandra , Krzymińska-Siemaszko Roma , Wieczorowska-Tobis Katarzyna , Deskur-Śmielecka Ewa
Published: January 2022

Chronic obstructive pulmonary disease (COPD) is a recognized risk factor for malnutrition. The European Respiratory Society (ERS) statement included nutritional status assessment and dietary intervention as essential components of comprehensive management in subjects with COPD. According to the GLIM algorithm, the first step in diagnosing malnutrition is risk screening with a validated tool. Our study aimed to assess the diagnostic performance of three screening tools (MNA-SF, MUST, and NRS-2002) used in the GLIM algorithm in older patients with COPD. Additionally, we evaluated the agreement between these tools in the diagnostics of malnutrition. We performed a cross-sectional study of 124 patients aged at least 60 years with COPD diagnosed, based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD). We assessed the participants’ nutritional status with the three examined screening questionnaires (MNA-SF, MUST, and NRS-2002). Regardless of their results, we performed full malnutrition diagnostics following the GLIM algorithm in all subjects. The proportion of malnourished participants varied from 18.5% for the MUST questionnaire to 27.4% for the MNA-SF and 57.3% for the NRS-2002 score. Based on the GLIM criteria, malnutrition was diagnosed in 48 subjects (38.7%). All assessed questionnaires had an unsatisfactory sensitivity against the GLIM criteria for malnutrition: it was fair (58.3%) for the MNA-SF tool and poor for the MUST and NRS-2002 questionnaires (47.9% for both questionnaires). Considering the negative health consequences of malnutrition, a full diagnostic including GLIM etiologic and phenotypic criteria should be recommended in all elderly patients with COPD, regardless of the screening results.
Primary Factors Influencing the Decision to Vaccinate against COVID-19 in the United States: A Pre-Vaccine Analysis
Authors: Varol Serkan , Catma Serkan , Reindl Diana , Serieux Elizabeth
Published: January 2022

Because vaccine hesitancy is a dynamic trait, it is critical to identify and compare the contributing factors at the different stages of a pandemic. The prediction of vaccine decision making and the interpretation of the analytical relationships among variables that encompass public perceptions and attitudes towards the COVID-19 pandemic have been extensively limited to the studies conducted after the administration of the first FDA-approved vaccine in December of 2020. In order to fill the gap in the literature, we used six predictive models and identified the most important factors, via Gini importance measures, that contribute to the prediction of COVID-19 vaccine acceptors and refusers using a nationwide survey that was administered in November 2020, before the widespread use of COVID-19 vaccines. Concerns about (re)contracting COVID-19 and opinions regarding mandatory face covering were identified as the most important predictors of vaccine decision making. By investigating the vaccine acceptors and refusers before the introduction of COVID-19 vaccines, we can help public health officials design and deliver individually tailored and dynamic vaccination programs that can increase the overall vaccine uptake.
Correspondence between Parents’ and Adolescents’ Sleep Duration
Authors: Jeon Eunyoung , Kim Nayoung
Published: January 2022

This study explored the correspondence between adolescents’ sleep duration and that of their parents and identified the factors affecting the appropriate sleep duration for adolescents. The data of 795 adolescents from the Korea National Health and Nutrition Examination Survey (2015–2018) were analyzed. We used Cohen’s kappa coefficient to measure the correspondence between adolescents’ sleep duration and that of their parents. A multiple logistic regression analysis was used to identify the factors affecting adequate sleep duration among adolescents. Our study found that factors such as adolescents’ gender, father’s education level, and drinking among adolescents and parents influenced the adolescents’ sleep duration. Second, a higher correspondence between the sleep duration of adolescents and that of mothers (Kappa = 0.213, p < 0.001) was found compared to that of fathers (Kappa = 0.064, p = 0.031). Finally, an adequate sleep duration among adolescents’ mothers was a major factor that influenced the adequate sleep duration of adolescents (OR = 2.494, 95% CI = 1.850–3.362, p < 0.001). Therefore, when organizing adolescent sleep education and management programs in various community sleep management institutions, the main caregiver’s sleep duration management and family drinking management should be combined. Additionally, gender equality awareness should be improved for parenting, including monitoring adolescents’ sleep accordingly.
Has Food Security and Nutritional Status Improved in Children 1–<10 Years in Two Provinces of South Africa between 1999 (National Food Consumption Survey) and 2018 (Provincial Dietary Intake Study (PDIS))
Authors: Steyn Nelia P. , Nel Johanna H. , Drummond Linda , Malczyk Sonia , Senekal Marjanne
Published: January 2022

The 1999 National Food Consumption Survey in South Africa showed that food insecurity (hunger) was prevalent in households with children aged one to <10 years. A repeat of the survey in two provinces: Gauteng (GTG) and the Western Cape (WC) was undertaken in 2018. Results showed that in all domains (living areas) in GTG, food shortage prevalence decreased between 1999 and 2018, from 55.0% to 29.6% in urban informal areas, from 34.1% to 19.4% in urban formal areas and from 42.1% to 15.6% in rural areas. While the prevalence of food shortage in urban formal areas in the WC remained similar in 2018, prevalence decreased from 81.8% to 35.7% in urban informal areas and from 38.3% to 20.6% in rural areas. Energy and macronutrient intakes improved significantly in GTG between 1999 and 2018 but not in the WC; intakes were significantly higher in the WC at both time points. The only significant change in stunting, wasting, overweight and obesity prevalence was that 7–<10-year-olds in GTG were significantly more likely to be wasted (BAZ < 2SD) in 2018 than in 1999 (20.2% versus 6.9% respectively). In the WC, 1–3-year-olds were significantly more likely to be obese in 2018 than in 1999 (8.1% versus 1.7% respectively) and 7–<10-year-olds were less likely to be stunted (14.5% versus 4.9% respectively). There were significant negative correlations between the hunger score and dietary variables in both provinces in 1999. In GTG in 2018, only the correlation with fat intake remained while there were still several significant correlations in WC in 2018. Changes in top 12 energy contributors reflect a shift to high or moderate energy foods low in nutrients from 1999 to 2018. Nutrient dense (high micronutrients, low energy/g) foods (e.g., fruit) fell off the list in 2018. Logistic regression analyses reflect the importance for food security of having a parent as head of the household and/or caregiver, and parents having grade 12 or higher education and being employed. We conclude that food security nutritional status indicators improved amongst 1–<10-year-old children especially in GTG between 1999 and 2018. However, the shift to poorer food choices and increase in wasting in older children and overweight in younger children are of concern.
Feasibility, Interrater Reliability and Internal Consistency of the German Environmental Audit Tool (G-EAT)
Authors: Fahsold Anne , Schmüdderich Kathrin , Verbeek Hilde , Holle Bernhard , Palm Rebecca
Published: January 2022

Dementia-specific environmental design has the potential to positively influence capabilities for daily living and quality of life in people with dementia living in nursing homes. To date, no reliable instrument exists for systematically assessing the adequacy of these built environments in Germany. This study aimed to test the adapted version of the Environmental Audit Tool—High Care (EAT-HC)—the German Environmental Audit Tool (G-EAT)—with regard to its feasibility, interrater reliability and internal consistency. The G-EAT was applied as a paper-pencil version in the German setting; intraclass correlation coefficients at the subscale level ranged from 0.662 (III) to 0.869 (IV), and 42% of the items showed at least substantial agreement (Cohen’s kappa ≥ 0.60). The results indicate the need to develop supplementary material in a manual that illustrates the meaning of the items and practical implications regarding dementia-specific environmental design. Furthermore, the intersectionality of built and physical environments must be considered when interpreting G-EAT results in future research and applications to residential long-term care practice.
The Redox Active [2Fe-2S] Clusters: Key-Components of a Plethora of Enzymatic Reactions—Part I: Archaea
Authors: Corsini Maddalena , Zanello Piero
Published: January 2022

The earliest forms of life (i.e., Archaea, Bacteria, and Eukarya) appeared on our planet about ten billion years after its formation. Although Archaea do not seem to possess the multiprotein machinery constituted by the NIF (Nitrogen Fixation), ISC (Iron Sulfur Cluster), SUF (sulfur mobilization) enzymes, typical of Bacteria and Eukarya, some of them are able to encode Fe-S proteins. Here we discussed the multiple enzymatic reactions triggered by the up-to-date structurally characterized members of the archaeal family that require the crucial presence of structurally characterized [2Fe-2S] assemblies, focusing on their biological functions and, when available, on their electrochemical behavior.
Insect Rearing Techniques for Biological Control Programs, a Component of Sustainable Agriculture in Brazil
Authors: Parra José Roberto Postali , Coelho Aloisio
Published: January 2022

This article describes the importance of rearing insects, whether on a small scale for research or a large scale for mass rearing, for use in biological control (BC) programs with macro-organisms. These inter- or multidisciplinary research programs are necessarily long-term and depend on rearing techniques for their complete development. Some successful examples of BC in Brazil are presented, including case studies of Trichogramma spp. These required broad bioecological studies that provided the basis for both mass rearing and transfer of the necessary technology to farmers. This has allowed Brazil to occupy a leadership position in biological control in “Open Fields”. For example, about three million ha are being treated with Trichogramma galloi (a native parasitoid), and about three and a half million ha with Cotesia flavipes (an exotic parasitoid) to control Diatraea saccharalis, the sugarcane borer. These natural enemies are produced by commercial firms, or by laboratories in sugar and alcohol plants themselves, in the case of C. flavipes.
Advanced Techniques for Design and Manufacturing in Marine Engineering
Authors: Mancuso Antonio , Tumino Davide
Published: January 2022

Modern engineering design processes are driven by the extensive use of numerical simulations, and naval architecture as well as ocean engineering are no exception [...]
Effects of the COVID-19 Pandemic on Farmers and Their Responses: A Study of Three Farming Systems in Kerala, South India
Authors: Menon Anamika , Schmidt-Vogt Dietrich
Published: January 2022

Particularly in countries with an agrarian economy, the COVID-19 pandemic has brought hardships faced by farmers into sharp focus. One of the most badly hit countries was India. This study aims to bring to light the effects of the COVID-19 pandemic on the livelihoods of farmers in three farming systems (coffee farming, Kole wetland paddy farming, and homestead farming) in the southern Indian state of Kerala. We collected the data using telephone interviews and studied the impacts (economic, social, institutional) of the pandemic on the selected farming systems, the responses of farmers (short and long term) to these impacts, and the ability of farmers to secure their livelihoods (by analyzing resilience capacities and transforming structures and processes of the farming systems). The methodological framework used was developed based on the Sustainable Livelihoods Approach and the Resilience Framework. We found significant impacts on the three studied farming systems due to COVID-19. As the impacts, responses, and ability to secure livelihoods varied across the three farming systems, we concluded that there is not a single solution that could be prescribed for all farming systems and that each land use system must be treated individually.
Rural and Urban Land Tourism and Destination Image: A Dual-Case Study Approach Examining Energy-Saving Behavior and Loyalty
Authors: Zheng Wei , Qiu Hongliang , Morrison Alastair M. , Wei Wei , Zhang Xihua
Published: January 2022

Although the significance of destination image is acknowledged, its effect on tourist reactions, especially energy-saving behavior, remains unknown. This research aimed to explore tourist energy-saving behavior (TESB) and loyalty (TL) in a rural land context by using the cognition-affect-behavior (CAB) model. The findings indicated: (1) destination image positively and directly influenced TESB and TL; (2) relationship quality variables, i.e., tourist satisfaction and destination trust, positively and separately mediated the associations of destination image with TESB and TL; and (3) a cross-validation approach of rural and urban cases documented support for the research findings. This study extends the destination image literature by introducing the CAB model and the cross-validation approach to examine energy-saving behavior and loyalty. It offers guidance and a reference for tourism destination practitioners to promote energy-saving behavior and loyalty through the enhancement of destination image and relationship quality.
Effect of Material Anisotropy on the Mechanical Response of Automotive Steel under High Strain Rates
Authors: Yin Sheng , Xue Yi , Cui Haotian , Pei Xinhua , Hu Chundong , Wang Yangxin , Tian Qingchao
Published: January 2022

A constitutive model for automobile steel with high elongation needs to be established to predict the dynamic deformation behavior under hydroforming applications. In order to clarify the confusing discrepancy in the essential parameters of the classical Cowper-Symonds (C-S) model, a series of automobile structural steels have been employed to investigate the strain rate response by conducting tensile dynamic deformation. Metallographic microscopy and orientation distribution functions were used to characterize the microstructure and texture components of the steels. The microstructure observation discloses that the matrix of all steels is mainly of ferrite and the texture constituent provides a framework for steel to withstand external deformation. The C-S model can be applied to simulate the dynamic deformation with satisfied expectations. It is concluded that the essential parameters D and p in the model show a specific relationship with the steel grade, and the parameter D is proportional to the steel grade and related to material anisotropy, while the parameter p is inversely proportional to the steel grade and has close links with the grain boundary characteristics.
Productivity Enhancement by Prediction of Liquid Steel Breakout during Continuous Casting Process in Manufacturing of Steel Slabs in Steel Plant Using Artificial Neural Network with Backpropagation Algorithms
Authors: Ansari Md Obaidullah , Chattopadhyaya Somnath , Ghose Joyjeet , Sharma Shubham , Kozak Drazan , Li Changhe , Wojciechowski Szymon , Dwivedi Shashi Prakash , Kilinc Huseyin Cagan , Królczyk Jolanta B. , Walczak Dominik
Published: January 2022

Breakout is one of the major accidents that often arise in the continuous casting shops of steel slabs in Bokaro Steel Plant, Jharkhand, India. Breakouts cause huge capital loss, reduced productivity, and create safety hazards. The existing system is not capable of predicting breakout accurately, as it considers only one process parameter, i.e., thermocouple temperature. The system also generates false alarms. Several other process parameters must also be considered to predict breakout accurately. This work has considered multiple process parameters (casting speed, mold level, thermocouple temperature, and taper/mold) and developed a breakout prediction system (BOPS) for continuous casting of steel slabs. The BOPS is modeled using an artificial neural network with a backpropagation algorithm, which further has been validated by using the Keras format and TensorFlow-based machine learning platforms. This work used the Adam optimizer and binary cross-entropy loss function to predict the liquid breakout in the caster and avoid operator intervention. The experimental results show that the developed model has 100% accuracy for generating an alarm during the actual breakout and thus, completely reduces the false alarm. Apart from the simulation-based validation findings, the investigators have also carried out the field application-based validation test results. This validation further unveiled that this breakout prediction method has a detection ratio of 100%, the frequency of false alarms is 0.113%, and a prediction accuracy ratio of 100%, which was found to be more effective than the existing system used in continuous casting of steel slab. Hence, this methodology enhanced the productivity and quality of the steel slabs and reduced substantial capital loss during the continuous casting of steel slabs. As a result, the presented hybrid algorithm of artificial neural network with backpropagation in breakout prediction does seem to be a more viable, efficient, and cost-effective method, which could also be utilized in the more advanced automated steel-manufacturing plants.
Non-Linear Dynamic Analysis on Hybrid Air Bearing-Rotor System under Ultra-High Speed Condition
Authors: Song Laiyun , Yuan Guoqin , Zhang Hongwen , Ding Yalin , Cheng Kai
Published: January 2022

The non-linear dynamic behavior of a hybrid air bearing-rotor system is very complicated and requires careful attention when designing to avoid spindle failure, especially under ultra-high speed condition. In this paper, the rotor trajectory of a hybrid air bearing-rotor system is obtained by solving the unsteady Reynolds equation and motion equations simultaneously. The typical non-linear behavior of hybrid air bearing-rotor systems is illustrated with the analysis of the rotor trajectory, the phase angle, time domain vibration and power spectral density. Furthermore, the influences of the rotor mass, external load, rotating speed and unbalanced mass on the non-linear behavior are investigated. Finally, the effect of structure parameters on the rotor trajectory is studied and the phenomenon under ultra-high speed condition is illustrated, which provides some new guidelines on the ultra-high speed air spindle design.
Morphological Study of Bio-Based Polymers in the Consolidation of Waterlogged Wooden Objects
Authors: Walsh-Korb Zarah , Stelzner Ingrid , dos Santos Gabriel Juliana , Eggert Gerhard , Avérous Luc
Published: January 2022

The removal of water from archaeological wooden objects for display or storage is of great importance to their long-term conservation. Any mechanical instability caused during drying can induce warping or cracking of the wood cells, leading to irreparable damage of the object. Drying of an object is commonly carried out in one of three ways: (i) air-drying with controlled temperature and relative humidity, (ii) drying-out of a non-aqueous solvent or (iii) freeze-drying. Recently, there has been great interest in the replacement of the standard, but limited, polyethylene glycol with biopolymers for wood conservation; however, their behaviour and action within the wood is not completely understood. Three polysaccharides—low-molar-mass (Mw) chitosan (Mw ca. 60,000 g/mol), medium-molar-mass alginate (Mw ca. 100,000 g/mol) and cellulose nanocrystals (CNCs)-are investigated in relation to their drying behaviour. The method of drying reveals a significant difference in the morphology of these biopolymers both ex situ and within the wood cells. Here, the effect these differences in structuration have on the coating of the wood cells and the biological and thermal stability of the wood are examined, as well as the role of the environment in the formation of specific structures. The role these factors play in the selection of appropriate consolidants and drying methods for the conservation of waterlogged archaeological wooden objects is also investigated. The results show that both alginate and chitosan are promising wood consolidants from a structural perspective and both improve the thermal stability of the lignin component of archaeological wood. However, further modification would be necessary to improve the biocidal activity of alginate before it could be introduced into wooden objects. CNCs did not prove to be sufficiently suitable for wood conservation as a result of the analyses performed here.
An Overview of Thermal Plasma Arc Systems for Treatment of Various Wastes in Recovery of Metals
Authors: Samal Sneha , Blanco Ignazio
Published: January 2022

Thermal plasma systems are being used for the recovery of metals from complex waste and minerals. The latter contain multiphase metals in various forms that are extremely tedious to separate. Thermal plasma arc melts the waste and minerals for qualitative plasma products for powder industries. In this overview, we briefly report a description of the various thermal plasma systems and their uses in recovering metal from metal-containing materials in the form of waste or minerals. Various plasma arc systems, such as transferred, nontransferred, and extended arc, have enabled the development of an efficient and environmentally friendly way to recover valuable metals from industrial wastes such as red mud and minerals such as ilmenite.
Wettability and Adhesion of Polyethylene Powder Treated with Non-Equilibrium Various Gaseous Plasma in Semi-Industrial Equipment
Authors: Jelínek Šourková Hana , Weberová Zuzana , Antoň Jakub , Špatenka Petr
Published: January 2022

Plasma treatment of polyethylene powder was carried out in low-pressure gaseous plasma sustained in a semi-industrial reactor powered with a microwave source, in which it was specifically worked with the residual atmosphere. Timed applications of plasma-treated powder in air atmosphere were carried out to study their influence on the adhesion. Based on wettability and adhesion, a treatment time of 5 min was selected for the study of other working gases (nitrogen, oxygen, hydrogen, argon and a mixture of nitrogen and hydrogen). The measurements of wettability showed the highest adhesion increase for nitrogen. The highest increase of adhesion and of surface oxygen contain shown by oxygen treatment. By contrast, treatment with hydrogen resulted in increased roughness of the sintered surface of the powder. The selection of appropriate working gases which are not standard in industrial processes enables one to atypically regulate the adhesion or wettability.
Tribocorrosion Behavior of NiTi Biomedical Alloy Processed by an Additive Manufacturing Laser Beam Directed Energy Deposition Technique
Authors: Buciumeanu Mihaela , Bagheri Allen , Silva Filipe Samuel , Henriques Bruno , Lasagni Andrés F. , Shamsaei Nima
Published: January 2022

The purpose of the present study was to experimentally assess the synergistic effects of wear and corrosion on NiTi alloy in comparison with Ti-6Al-4V alloy, the most extensively used titanium alloy in biomedical applications. Both alloys were processed by an additive manufacturing laser beam directed energy deposition (LB-DED) technique, namely laser engineered net shaping (LENS), and analyzed via tribocorrosion tests by using the ball-on-plate configuration. The tests were carried out in phosphate buffered saline solution at 37 °C under open circuit potential (OCP) to simulate the body environment and temperature. The synergistic effect of wear and corrosion was found to result in an improved wear resistance in both materials. It was also observed that, for the process parameters used, the LB-DED NiTi alloy exhibits a lower tendency to corrosion as compared to the LB-DED Ti-6Al-4V alloy. It is expected that, during the service life as an implant, the NiTi alloy is less susceptible to the metallic ions release when compared with the Ti-6Al-4V alloy.
Structural and Magnetic Properties of Inverse-Heusler Mn2FeSi Alloy Powder Prepared by Ball Milling
Authors: Životský Ondřej , Skotnicová Kateřina , Čegan Tomáš , Juřica Jan , Gembalová Lucie , Zažímal František , Szurman Ivo
Published: January 2022

Ternary Mn2FeSi alloy was synthesized from pure elemental powders by mechanical alloying, using a high-energy planetary ball mill. The formation of an inverse-Heusler phase after 168 h of milling and subsequent annealing at 1173 K for 1.5 h was confirmed by X-ray diffraction. The diffractogram analysis yielded XA structure and the lattice parameter 0.5677 nm in a good agreement with the theoretically obtained value of 0.560 nm. The final powder was formed by particles of irregular shape and median diameter D50 of 3.8 μm and their agglomerates. The chemical analysis resulted in the mean composition of 49.0 at.% Mn, 25.6 at.% Fe and 25.4 at.% Si. At room temperature, the prepared samples featured a heterogeneous magnetic structure consisting of dominant paramagnetic phase confirmed by Mössbauer spectrometry and a weak ferro-/ferrimagnetic contribution detected by magnetization curves. From the field-cooled and zero-field-cooled curves the Néel temperature of 67 K was determined.
A Comparative Study on the Structure and Quality of SLM and Cast AISI 316L Samples Subjected to WEDM Processing
Authors: Machno Magdalena , Franczyk Emilia , Bogucki Rafał , Matras Andrzej , Zębala Wojciech
Published: January 2022

Additive manufacturing technologies are increasingly used in the production of semi-finished workpieces intended for further processing. This entails the need to investigate the machinability and final properties of such products. Comparative research on wire electrical discharge machining (WEDM) processes performed with two kinds of AISI 316L stainless steel workpieces is presented in this paper. The first workpiece was made by selective laser melting (SLM), while the second one was casting. Both working materials were cut with current values ranging from 8 to 72 amps. A comparison of roughness, structure and chemical composition of machined surfaces was performed between the two kinds of specimens. For the SLM sample, parameters of the cutting process that provide relatively low surface roughness (Ra ≤ 10 µm) with the simultaneous maximization of the process efficiency were determined. It was found that in the case of applying high current values (72 amp.), more favorable properties of the treated surface were obtained for the SLM sample than for the cast one.
Voting-Based Ensemble Learning Algorithm for Fault Detection in Photovoltaic Systems under Different Weather Conditions
Authors: Yang Nien-Che , Ismail Harun
Published: January 2022

A photovoltaic (PV) system is one of the renewable energy resources that can help in meeting the ever-increasing energy demand. However, installation of PV systems is prone to faults that can occur unpredictably and remain challenging to detect. Major PV faults that can occur are line-line and open circuits faults, and if they are not addressed appropriately and timely, they may lead to serious problems in the PV system. To solve this problem, this study proposes a voting-based ensemble learning algorithm with linear regression, decision tree, and support vector machine (EL-VLR-DT-SVM) for PV fault detection and diagnosis. The data acquisition is performed for different weather conditions to trigger the nonlinear nature of the PV system characteristics. The voltage-current characteristics are used as input data. The dataset is studied for a deeper understanding, and pre-processing before feeding it to the EL-VLR-DT-SVM. In the pre-processing step, data are normalized to obtain more feature space, making it easy for the proposed algorithm to discriminate between healthy and faulty conditions. To verify the proposed method, it is compared with other algorithms in terms of accuracy, precision, recall, and F-1 score. The results show that the proposed EL-VLR-DT-SVM algorithm outperforms the other algorithms.
Inter-Specialty Controversies on the Treatment of Cardiovascular Diseases during Pregnancy: A Questionnaire Study
Authors: Dziadosz Dominika , Dudzic Katarzyna , Morawska Irmina , Topolska Dominika , Urban Katarzyna , Mizia-Stec Katarzyna , Krzych Łukasz J.
Published: January 2022

Background and Objectives: Management of cardiovascular disease (CVD) during pregnancy is challenging and usually requires eminence-based decisions due to limited strong-evidence data in this field. The purpose of our study was to compare the attitudes of anaesthesiologists, cardiologists, and gynaecologists towards the diagnosis and treatment of potentially life-threatening CVDs during pregnancy. Materials and Methods: A cross-sectional, questionnaire-based study was performed among 111 doctors (55 anaesthesiologists, 36 cardiologists, 20 gynaecologists). Personal opinions on the recommendations (n = 19) regarding rare, potentially life-threatening CVDs during pregnancy were recorded using a five-item Likert scale. Results: Opinions regarding eight statements (42%) varied substantially between specialties (p < 0.05). The most distinctive differences between physicians concerned the following recommendations: “thrombolysis should only be used in pulmonary embolism with cardiogenic shock” (agree: 52.7% of anaesthesiologists, 80.4% of cardiologists, 25.0% of gynaecologists; p < 0.001); “women with the antiphospholipid syndrome should restart treatment with vitamin K antagonists from the second trimester of pregnancy” (agree: 12.7% of anaesthesiologists, 69.4% of cardiologists, 20.0% of gynaecologists; p < 0.001); “women with symptomatic pulmonary hypertension should have a Swan–Ganz catheter inserted for labour” (agree: 20.0% of anaesthesiologists, 11.1% of cardiologists, 55.0% of gynaecologists; p = 0.001). Conclusions: Physicians’ opinions regarding diagnostics and treatment of CVDs in pregnancy remain controversial. A multidisciplinary approach is recommended to ensure the safety and effectiveness of management in these unique medical conditions.
Analgesic Effects of Interferential Current Therapy: A Narrative Review
Authors: Rampazo Érika Patrícia , Liebano Richard Eloin
Published: January 2022

Background and Objectives: Transcutaneous electrical stimulation of low- and medium-frequency currents is commonly used in pain management. Interferential current (IFC) therapy, a medium frequency alternating current therapy that reportedly reduces skin impedance, can reach deeper tissues. IFC therapy can provide several different treatment possibilities by adjusting its parameters (carrier frequency, amplitudemodulated frequency, sweep frequency, sweep mode or swing pattern, type of application (bipolar or quadripolar), time of application and intensity). The objective of this review article is to discuss the literature findings on the analgesic efficacy of IFC therapy. Conclusions: According to the literature, IFC therapy shows significant analgesic effects in patients with neck pain, low back pain, knee osteoarthritis and post-operative knee pain. Most of the IFC parameters seem not to influence its analgesic effects. We encourage further studies to investigate the mechanism of action of IFC therapy.
A MEMS-Based Co-Oscillating Electrochemical Vector Hydrophone
Authors: Zhong Anxiang , Chen Mingwei , Lu Yulan , Chen Jian , Chen Deyong , Wang Junbo
Published: January 2022

Aiming at the development needs of low-frequency and high-sensitivity vector hydrophones, this paper has developed a micro-electro-mechanical system (MEMS) based co-oscillating electrochemical vector hydrophone. We obtained the optimized geometric parameters through simulation analysis of the diameter of the rubber membrane, the length of the flow channel and the diameter of the flow holes. Based on the simulation results, electrodes were fabricated using MEMS technology, and were then assembled and tested. Device characterization was conducted, where the sensitivity and bandwidth were quantified as 0.5–150 Hz, −187 dB ref. 1 V/μPa, respectively. Compared with a previously reported co-oscillating vector hydrophone, the co-oscillating vector hydrophone developed in this article featured a lower working frequency band.
Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics
Authors: Subsomwong Phawinee , Doohan Dalla , Fauzia Kartika Afrida , Akada Junko , Matsumoto Takashi , Yee Than Than , Htet Kyaw , Waskito Langgeng Agung , Tuan Vo Phuoc , Uchida Tomohisa , Matsuhisa Takeshi , Yamaoka Yoshio
Published: January 2022

Evaluation of Helicobacter pylori resistance to antibiotics is crucial for treatment strategy in Myanmar. Moreover, the genetic mechanisms involved remain unknown. We aimed to investigate the prevalence of H. pylori infection, antibiotic resistance, and genetic mechanisms in Myanmar. One hundred fifty patients from two cities, Mawlamyine (n = 99) and Yangon (n = 51), were recruited. The prevalence of H. pylori infection was 43.3% (65/150). The successfully cultured H. pylori isolates (n = 65) were tested for antibiotic susceptibility to metronidazole, levofloxacin, clarithromycin, amoxicillin, and tetracycline by Etest, and the resistance rates were 80%, 33.8%, 7.7%, 4.6%, and 0%, respectively. In the multidrug resistance pattern, the metronidazole–levofloxacin resistance was highest for double-drug resistance (16/19; 84.2%), and all triple-drug resistance (3/3) was clarithromycin–metronidazole–levofloxacin resistance. Twenty-three strains were subjected to next-generation sequencing to study their genetic mechanisms. Interestingly, none of the strains resistant to clarithromycin had well-known mutations in 23S rRNA (e.g., A2142G, A2142C, and A2143G). New type mutation genotypes such as pbp1-A (e.g., V45I, S/R414R), 23S rRNA (e.g., T248C), gyrA (e.g., D210N, K230Q), gyrB (e.g., A584V, N679H), rdxA (e.g., V175I, S91P), and frxA (e.g., L33M) were also detected. In conclusion, the prevalence of H. pylori infection and its antibiotic resistance to metronidazole was high in Myanmar. The H. pylori eradication regimen with classical triple therapy, including amoxicillin and clarithromycin, can be used as the first-line therapy in Myanmar. In addition, next-generation sequencing is a powerful high-throughput method for identifying mutations within antibiotic resistance genes and monitoring the spread of H. pylori antibiotic-resistant strains.
Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population
Authors: Isgin-Atici Kubra , Alathari Buthaina E. , Turan-Demirci Busra , Sendur Suleyman Nahit , Lay Incilay , Ellahi Basma , Alikasifoglu Mehmet , Erbas Tomris , Buyuktuncer Zehra , Vimaleswaran Karani Santhanakrishnan
Published: January 2022

Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24–50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.
Switching to Regular Diet Partially Resolves Liver Fibrosis Induced by High-Fat, High-Cholesterol Diet in Mice
Authors: Farooq Muhammad , Hameed Huma , Dimanche-Boitrel Marie-Thérèse , Piquet-Pellorce Claire , Samson Michel , Le Seyec Jacques
Published: January 2022

The globally prevalent disease, non-alcoholic steatohepatitis (NASH), is characterized by a steatotic and inflammatory liver. In NASH patients, tissue repair mechanisms, activated by the presence of chronic liver damage, lead to the progressive onset of hepatic fibrosis. This scar symptom is a key prognostic risk factor for liver-related morbidity and mortality. Conflicting reports discuss the efficiency of dietary interventions on the reversibility of advanced fibrosis established during NASH. In the present study, the effect of dietary interventions was investigated in the outcome of the fibrosis settled in livers of C57BL/6J mice on a high-fat, high-cholesterol diet (HFHCD) for 5 or 12 consecutive weeks. Various clinico-pathological investigations, including a histological analysis of the liver, measurement of plasma transaminases, steatosis and fibrosis, were performed. To assess the effectiveness of the dietary intervention on established symptoms, diseased mice were returned to a standard diet (SD) for 4 or 12 weeks. This food management resulted in a drastic reduction in steatosis, liver injuries, inflammatory markers, hepatomegaly and oxidative stress and a gradual improvement in the fibrotic state of the liver tissue. In conclusion, our results demonstrated that dietary intervention can partially reverse liver fibrosis induced by HFHCD feeding.
Clinical Impact of Mediterranean Diet Adherence before and after Bariatric Surgery: A Narrative Review
Authors: Gastaldo Isabella , Casas Rosa , Moizé Violeta
Published: January 2022

The population suffering from obesity is rapidly increasing all over the world. Bariatric surgery has shown to be the treatment of choice in patients with severe obesity. A Mediterranean diet has long been acknowledged to be one of the healthiest dietary patterns associated with a lower incidence of many chronic diseases. The aim of the present narrative review is to summarize the existing research on the clinical impact of a Mediterranean diet before and after bariatric surgery, focusing on its effects on weight loss and improvement in comorbidities. Although the current knowledge is limited, this information could add value and emphasize the importance of adopting a Mediterranean diet before and after bariatric surgery.
Effects of Coffee on the Gastro-Intestinal Tract: A Narrative Review and Literature Update
Authors: Nehlig Astrid
Published: January 2022

The objective of the present research was to review the state of the art on the consequences of drinking coffee at the different levels of the gastrointestinal tract. At some steps of the digestive process, the effects of coffee consumption seem rather clear. This is the case for the stimulation of gastric acid secretion, the stimulation of biliary and pancreatic secretion, the reduction of gallstone risk, the stimulation of colic motility, and changes in the composition of gut microbiota. Other aspects are still controversial, such as the possibility for coffee to affect gastro-esophageal reflux, peptic ulcers, and intestinal inflammatory diseases. This review also includes a brief summary on the lack of association between coffee consumption and cancer of the different digestive organs, and points to the powerful protective effect of coffee against the risk of hepatocellular carcinoma. This review reports the available evidence on different topics and identifies the areas that would most benefit from additional studies.
A 5-Year Study of Lithium and Valproic Acid Drug Monitoring in Patients with Bipolar Disorders in an Italian Clinical Center
Authors: Carli Marco , Risaliti Eleonora , Francomano Mena , Kolachalam Shivakumar , Longoni Biancamaria , Bocci Guido , Maggio Roberto , Scarselli Marco
Published: January 2022

Therapeutic drug monitoring (TDM) is an effective tool used to improve the pharmacological treatment in clinical practice, especially to detect subtherapeutic drug plasma concentration (Cp) in order to consider a change of dosage during treatment and reach its putative therapeutic range. In this study, we report the Cp values of lithium and valproic acid (VPA), alone and in combination, mostly in bipolar patients admitted to an Italian clinical center of the University of Pisa during the years 2016–2020, which include 12,294 samples of VPA, 7449 of lithium and 1118 of both in combination. Lithium and VPA are the most utilized drugs in treating bipolar disorders, and their TDM is strongly recommended by recent guidelines. In relation to lithium Cp monitoring, several studies have underlined that 0.5–0.8 mmol/L is the optimal range for chronic treatment, and below 0.4 mmol/L, it is unlikely to produce a clinical response. For VPA, the therapeutic range is 50–100 μg/mL and a linear correlation between Cp and clinical efficacy has been proposed, where below 50 μg/mL, the clinical efficacy of VPA has not been proven thus far. Toxic levels of both drugs were rarely found in our study, while a high percentage of patients, about one-third, had sub-therapeutic Cp during their treatments. In addition, in several cases of patients receiving multiple blood sampling, the initial subtherapeutic Cp changed only partially without reaching its therapeutic window. In relation to age, we found a higher percentage of lithium and VPA Cp values in range in the adolescents than in the adults and elderly groups. No differences were reported when analyzing the distribution of Cp values in males and females. In conclusion, this present study suggests that TDM is widely used by many specialists, but there is still a window of improvement for optimizing pharmacological treatments in clinical practice.
Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation
Authors: Salvati Anna , Poelstra Klaas
Published: January 2022

Drug targeting and nanomedicine are different strategies for improving the delivery of drugs to their target. Several antibodies, immuno-drug conjugates and nanomedicines are already approved and used in clinics, demonstrating the potential of such approaches, including the recent examples of the DNA- and RNA-based vaccines against COVID-19 infections. Nevertheless, targeting remains a major challenge in drug delivery and different aspects of how these objects are processed at organism and cell level still remain unclear, hampering the further development of efficient targeted drugs. In this review, we compare properties and advantages of smaller targeted drug constructs on the one hand, and larger nanomedicines carrying higher drug payload on the other hand. With examples from ongoing research in our Department and experiences from drug delivery to liver fibrosis, we illustrate opportunities in drug targeting and nanomedicine and current challenges that the field needs to address in order to further improve their success.
Justification of the Use of Composite Metal-Metal-Polymer Parts for Functional Structures
Authors: Lubimyi Nickolay S. , Polshin Andrey A. , Gerasimov Michael D. , Tikhonov Alexander A. , Antsiferov Sergey I. , Chetverikov Boris S. , Ryazantsev Vladislav G. , Brazhnik Julia , Ridvanov İsmail
Published: January 2022

The additive manufacturing of metal parts takes up an increasing number of areas of mechanical engineering, but it still remains too expensive for mass use. Based on the experience in the production of combined metal-metal-polymer forming parts of molds, a new method for the production of composite parts from a metal shell filled with metal-polymer is proposed. As a basis for the study, strength calculations are given by the finite element method for the details of the exoskeleton and a sample of simplified geometry. Comparison of the strength characteristics of parts made of various materials and their combinations showed high strength characteristics of a composite part made of a metal shell and a metal-polymer filler. The metal-metal polymer composite part is distinguished not only by its high strength but also by a significantly lower cost, due to the reduction in the volume of 3D printing with metal. The problems of obtaining composite structures are also discussed. The main problem is the development of a metal-polymer casting technology. The process of filling a thin-walled shell with a metal-polymer causes difficulty.
Analysis of Stock-Dependent Arrival Process in a Retrial Stochastic Inventory System with Server Vacation
Authors: Sugapriya C. , Nithya M. , Jeganathan K. , Anbazhagan N. , Joshi Gyanendra Prasad , Yang Eunmok , Seo Suseok
Published: January 2022

The present study deals with the stock-dependent Markovian demand of a retrial queueing system with a single server and multiple server vacation. The items are restocked under a continuous review (s,Q) ordering policy. When there is no item in the system, the server goes on vacation. Further, any arrival demand permits entry into an infinite orbit whenever the server is on vacation. In the Matrix geometric approach with the Neuts-Rao truncation technique, the steady-state joint distribution of the number of customers in orbit, the server status, and the inventory level is obtained. Under the steady-state conditions, some significant system performance measures, including the long-run total cost rate, are derived, and the Laplace-Stieltjes transform is also used to investigate the waiting time distribution. According to various considerations of uncontrollable parameters and costs, the merits of the proposed model, especially the important characteristics of the system with stock dependency over non-stock dependency, are explored. Ultimately, the important facts and ideas behind this model are given in conclusion.