bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanosensor Based on the Circular Ring with External Rectangular Ring Structure
Authors: Chang Shuwen , Yan Shubin , Su Yiru , Wang Jin , Cao Yuhao , Zhang Yi , Wu Taiquan , Ren Yifeng
Published: June 2024

This paper presents a novel nanoscale refractive index sensor, which is produced by using a metal–insulator–metal (MIM) waveguide structure coupled with the circular ring with an external rectangular ring (CRERR) structure with the Fano resonance phenomenon. In this study, COMSOL software was used to model and simulate the structure, paired with an analysis of the output spectra to detail the effect of constructional factors on the output Fano curve as measured from a finite element method. After a series of studies, it was shown that an external rectangular ring is the linchpin of the unsymmetrical Fano resonance, while the circular ring’s radius strongly influences the transducer’s capability to achieve a maximum for 3180 nm/RIU sensitivity and a FOM of 54.8. The sensor is capable of achieving sensitivities of 0.495 nm/mgdL−1 and 0.6375 nm/mgdL−1 when detecting the concentration of the electrolyte sodium and potassium ions in human blood and is expected to play an important role in human health monitoring.
Different Phenotypic, Photosynthetic, and Physiological Responses to Flooding between Q. nuttallii and Q. palustris
Authors: Sun Tiantian , Wang Mengzhu , Li Xin , Chen Yongxia , Zhang Wangxiang
Published: June 2024

Flooding stress is an increasingly serious problem in wetlands, often affecting large areas of crops and timber production areas. The current study aimed to explore the species differences in responses to flooding stress between Q. nuttallii and Q. palustris in an outdoor environment. All the tested plants survived after a 60-day flooding treatment that left 5 cm of water above the soil surface. This suggests that the two species are flood-tolerant, so they can be applied in the construction of riparian protection forests and wetland restoration. Compared with control conditions, flooding treatment significantly decreased seedling height and diameter and the Pn, Gs, Tr, Fv/Fm, ABS/CSm, TR0/CSm, ET0/CSm, RE0/CSm, IAA, and GA3 content and significantly increased the content of MDA, H2O2, soluble sugars, SOD, POD, ADH, ABA, and JA. Under control conditions, Q. nuttallii showed significantly greater growth and photosynthetic capability than Q. palustris. In contrast, Q. palustris exhibited less inhibition of growth and photosynthesis, oxidative stress levels, and antioxidant enzyme activities than Q. nuttallii under flooding conditions. The findings indicate that Q. palustris has better defense mechanisms against the damage caused by flooding stress than Q. nuttallii. Q. nuttallii was more sensitive and responsive to flooding than Q. palustris.
The Functional Characterization of MaGS2 and Its Role as a Negative Regulator of Ciboria shiraiana
Authors: Yidilisi Keermula , Wang Yuqiong , Guo Zixuan , Guo Yangyang , Kang Xiaoru , Li Shan , Zhang Wenhao , Chao Nan , Liu Li
Published: June 2024

Glutamine synthetase (GS) is a key enzyme involved in nitrogen metabolism. GS can be divided into cytosolic and plastidic subtypes and has been reported to respond to various biotic and abiotic stresses. However, little research has been reported on the function of GS in mulberry. In this study, the full length of MaGS2 was cloned, resulting in 1302 bp encoding 433 amino acid residues. MaGS2 carried the typical GS2 motifs and clustered with plastidic-subtype GSs in the phylogenetic analysis. MaGS2 localized in chloroplasts, demonstrating that MaGS2 is a plastidic GS. The expression profile showed that MaGS2 is highly expressed in sclerotiniose pathogen-infected fruit and sclerotiniose-resistant fruit, demonstrating that MaGS2 is associated with the response to sclerotiniose in mulberry. Furthermore, the overexpression of MaGS2 in tobacco decreased the resistance against Ciboria shiraiana, and the knockdown of MaGS2 in mulberry by VIGS increased the resistance against C. shiraiana, demonstrating the role of MaGS2 as a negative regulator of mulberry resistance to C. shiraiana infection.
The Promising Potential of Cold Atmospheric Plasma Therapies
Authors: Stańczyk Beata , Wiśniewski Marek
Published: June 2024

The outstanding properties and chemistry of cold atmospheric plasma (CAP) are not sufficiently understood due to their relatively complex systems and transient properties. In this paper, we tried to present a detailed review of the applications of CAP in modern medicine, highlighting the biochemistry of this phenomenon. Due to its unique characteristics, CAP has emerged as a promising tool in various medical applications. CAP, as a partially—or fully ionized—gas-retaining state of quasi-neutrality, contains many particles, such as electrons, charged atoms, and molecules displaying collective behaviour caused by Coulomb interactions. CAP can be generated at atmospheric pressure, making it suitable for medical settings. Cold plasma’s anti-microbial properties create an alternative method to antibiotics when treating infections. It also enhances cell proliferation, migration, and differentiation, leading to accelerated tissue regeneration. CAP can also be a powerful tool in anti-tumour therapies, stem cell proliferation, dental applications, and disease treatment, e.g., neurology. It is our belief that this article contributes to the deeper understanding of cold plasma therapy and its potential in medicine. The objective of this study is to demonstrate the potential of this relatively novel approach as a promising treatment modality. By covering a range of various biomedical fields, we hope to provide a comprehensive overview of CAP applications for multiple medical conditions. In order to gain further insight into the subject, we attempted to gather crucial research and evidence from various studies, hopefully creating a compelling argument in favour of CAP therapy. Our aim is to highlight the innovative aspects of CAP therapy where traditional methods may have limitations. Through this article, we intend to provide a convenient reference source for readers engaged in the examination of CAP’s potential in medicine.
Use of Nanobubbles to Improve Mass Transfer in Bioprocesses
Authors: Silva Javier , Arias-Torres Laura , Carlesi Carlos , Aroca Germán
Published: June 2024

Nanobubble technology has emerged as a transformative approach in bioprocessing, significantly enhancing mass-transfer efficiency for effective microbial activity. Characterized by their nanometric size and high internal pressure, nanobubbles possess distinct properties such as prolonged stability and minimal rise velocities, allowing them to remain suspended in liquid media for extended periods. These features are particularly beneficial in bioprocesses involving aerobic strains, where they help overcome common obstacles, such as increased culture viscosity and diffusion limitations, that traditionally impede efficient mass transfer. For instance, in an experimental setup, nanobubble aeration achieved 10% higher soluble chemical oxygen demand (sCOD) removal compared to traditional aeration methods. Additionally, nanobubble-aerated systems demonstrated a 55.03% increase in caproic acid concentration when supplemented with air nanobubble water, reaching up to 15.10 g/L. These results underscore the potential of nanobubble technology for optimizing bioprocess efficiency and sustainability. This review delineates the important role of the mass-transfer coefficient (kL) in evaluating these interactions and underscores the significance of nanobubbles in improving bioprocess efficiency. The integration of nanobubble technology in bioprocessing not only improves gas exchange and substrate utilization but also bolsters microbial growth and metabolic performance. The potential of nanobubble technology to improve the mass-transfer efficiency in biotechnological applications is supported by emerging research. However, to fully leverage these benefits, it is essential to conduct further empirical studies to specifically assess their impacts on bioprocess efficacy and scalability. Such research will provide the necessary data to validate the practical applications of nanobubbles and identify any limitations that need to be addressed in industrial settings.
Study on the Thermal Expansion Characteristics of Coal during CO2 Adsorption
Authors: Song Jinxing , Sun Yajie , Liu Yufang
Published: June 2024

The adsorption of CO2 fracturing fluid into coal reservoirs causes the expansion of the coal matrix volume, resulting in changes in the fracture opening, which alters the permeability of the coal reservoir. However, it is not yet clear whether thermal expansion during CO2 adsorption on coal is the main cause of coal adsorption expansion. Therefore, by testing the thermal properties, expansion coefficient, and adsorption heat of the three coal samples, the adsorption thermal expansion characteristics of coal and their impact on the permeability of coal reservoirs are clarified. The results reveal the following: (1) Under the same conditions, the adsorption heat increases with increasing pressure, while it decreases with increasing temperature. The relationship between adsorption heat and pressure conforms to the Langmuir equation before 40 °C, and it follows a second-order equation beyond 40 °C. At 100 °C, the adsorption heat of coal samples to CO2 is primarily determined by temperature. (2) The maximum temperature variation in coal samples from Xinjiang, Liulin, and Zhaozhuang during CO2 adsorption is 95.767 °C, 87.463 °C, and 97.8 °C, respectively. The maximum thermal expansion rates are 12.66%, 5.74%, and 14.37%, and the maximum permeability loss rates are 16.16%, 7.51%, and 18.24%, respectively, indicating that thermal expansion is the main reason for coal adsorption expansion. (3) This research can elucidate the impact of CO2 fracturing fluid on coal reservoirs and its potential application value, thus providing theoretical support for coalbed methane development and CO2 geological storage.
Simulation of Elbow Erosion of Gas–Liquid–Solid Three-Phase Shale Gas Gathering Pipeline Based on CFD-DEM
Authors: Wang Yixuan , Tan Rui , Chang Bei , Chen Bin , Li Junxiang , Lu Qianli , Zhang Tao
Published: June 2024

Shale gas gathering pipelines often contain liquid water and solid sand in the early stage of production, which leads to the failure of pipeline components easily under the action of gas–liquid–solid three phases. A computational fluid dynamics (CFD) model based on the fluid volume method (VOF) and discrete element method (DEM) was established to study the flow law of gas–liquid–solid three-phase flow in the elbow of shale gas gathering pipeline and the erosion law of the inner surface of the elbow was studied by coupling the Oka erosion prediction model. By comparing the experimental results of erosion damage of the elbow, it is found that the model established can well predict the erosion characteristics and erosion amount under the action of three phases. Combined with the field pipeline parameters and operating conditions, the paper further simulates the elbow erosion behavior under relevant working conditions. The results show that the particles rotate clockwise from the outer wall of the pipe through the bottom of the pipe when passing through the elbow under the action of gas and water phases. When the gas velocity increases, the particles at the elbow mainly gather at the bottom of the elbow and the wall of the outer arch. When the water content increases gradually, the particles gathered on the outer arch wall of the elbow move along the outer arch wall of the elbow and face the inner arch surface gradually, and the erosion area is mainly concentrated on the outer arch wall of the elbow and the outlet horizontal pipe. Under the condition of the liquid phase, the movement characteristics of the water phase and particles in the elbow of the gas gathering pipeline and the erosion characteristics of the pipeline surface are obviously different from those under the condition of the gas–solid two-phase. The model and simulation results established in this paper provide a reference for the erosion damage protection of shale gas gathering pipeline elbow.
Investigation of the Dominant Effects of Non-Spherical Particles on Particle–Wall Collisions
Authors: Cen Zhoutao , Wu Yuxin , Wang Jingyu , Liu Jie , Zhou Minmin , Chen Shukuan , Zhao Dongqiang
Published: June 2024

A deep understanding of the particle–wall collision (PWC) behaviors of non-spherical particles is important for managing gas–solid flows in industrial applications. It is important to identify the dominant parameters and to develop the common PWC prediction models for typical non-spherical particles. In this paper, different types of non-spherical particles were used to conduct the fundamental experiments. The effects of key parameters such as particle size, non-sphericity, wall roughness, and impact angle were analyzed. The results show that the trends of the collision coefficients with the impact angle for all non-spherical particles are similar. The dominant factors of particle–wall collisions are particle sphericity and wall roughness. A model with four parameters was fitted from the experimental data. The model can predict the collisions of non-spherical particles on rough steel walls with sizes ranging from 50 to 550 microns.
Night Eating Syndrome: A Review of Etiology, Assessment, and Suggestions for Clinical Treatment
Authors: Bargagna Miria , Casu Mirko
Published: June 2024

Night Eating Syndrome (NES) is a distinct eating disorder characterized by recurrent episodes of night eating, either through excessive food consumption after the evening meal or eating after awakening from sleep. Despite its recognition, there remains a dearth of research on NES, limiting our understanding of its etiology, prevalence, diagnosis, and treatment. This paper conducts a narrative review spanning a wide spectrum of studies focusing on the etiology, assessment, and clinical treatment strategies of NES. This review traces the historical evolution of NES definitions, distinguishes NES from obesity-related eating behaviors and other eating disorders, explores the psychological determinants of NES, and discusses existing therapeutic options. This review highlights the complex etiology of NES, influenced by circadian rhythms, hormonal changes, psychological distress, and personality traits. It emphasizes the need for reliable assessment tools and a holistic approach to treatment, considering the high comorbidity of NES with other psychiatric and medical conditions. Current treatment options, such as cognitive behavioral therapy and pharmacotherapy, show promise but require further research for refinement. NES remains underdiagnosed and undertreated, with challenges including unclear diagnostic criteria, comorbidities, and lack of evidence-based treatments. Future research should focus on developing reliable assessment tools, exploring etiology, comparing treatment approaches, and considering prevention strategies, utilizing diverse and representative samples to advance our understanding and improve clinical care.
Exploring Age Differences in Absorption and Enjoyment during Story Listening
Authors: Mathiesen Signe Lund , Hedger Stephen C. Van , Irsik Vanessa C. , Bain Matthew M. , Johnsrude Ingrid S. , Herrmann Björn
Published: June 2024

Using naturalistic spoken narratives to investigate speech processes and comprehension is becoming increasingly popular in experimental hearing research. Yet, little is known about how individuals engage with spoken story materials and how listening experiences change with age. We investigated absorption in the context of listening to spoken stories, explored predictive factors for engagement, and examined the utility of a scale developed for written narratives to assess absorption for auditory materials. Adults aged 20–78 years (N = 216) participated in an online experimental study. Participants listened to one of ten stories intended to be engaging to different degrees and rated the story in terms of absorption and enjoyment. Participants of different ages rated the stories similarly absorbing and enjoyable. Further, higher mood scores predicted higher absorption and enjoyment ratings. Factor analysis showed scale items approximately grouped according to the original scale dimensions, suggesting that absorption and enjoyment experiences may be similar for written and spoken stories, although certain items discriminated less effectively between stories intended to be more or less engaging. The present study provides novel insights into how adults of different ages engage in listening and supports using naturalistic speech stimuli in hearing research.
Review and Critique of the Quantitative Literature Regarding Attitudes toward Consensual Non-Monogamy (CNM)
Authors: Rye B. J.
Published: June 2024

This paper is a review of the recent literature on attitudes toward consensual non-monogamy (CNM). These attitudes are constrained to evaluations of people who practice CNM, CNM relationships, and CNM concepts; willingness to engage in or personal interest in practicing CNM is not included in this review. Relevant published research was located through database searches, as well as by perusing references and citations. Based on over two dozen investigations, it is concluded that average attitudes toward CNM are around neutral, with some slightly negative and some slightly positive. Studies taking a comparative perspective—whereby monogamous couples are pitted against CNM couples—overwhelmingly find more favorable attitudes toward monogamy. This literature supports assertions of the prevalence of monocentrism/compulsory monogamy. Further, some researchers investigated sociodemographic and psychological variables as predictors of CNM attitudes. Considering demographic characteristics, those who identify as monogamous and heterosexual tend to be more negative toward CNM relative to their counterparts, and most of the research suggests there are no gender differences in CNM attitudes. In terms of psychological variables, those reflecting authoritarian ideological values tended to predict CNM attitudes the best. The psychological variables are interpreted within the broader dual-process motivational model of prejudice with attention to authoritarianism and social dominance. To conclude, measurement issues are discussed, existing instruments are critiqued, and recommendations are made for which instruments are appropriate for different research goals. Specifically, the Attitudes towards Polyamory scale is a concise, unidimensional instrument with sound psychometric properties, making it a good general assessment of polyamory or CNM. Created using excellent test construction techniques, the Multidimensional Measurement of Attitudes toward Consensual Non-Monogamy (MACS) is a very promising belief-based CNM attitudes scale with three factors. Finally, directions for future research are discussed with an emphasis on differentiating between beliefs and attitudes as suggested by attitude theory, with most CNM attitude scales conflating the former with the latter.
Exergames as an Effective Alternative to Real Environmental Tennis Training for Adolescents
Authors: Flôres Fábio , Silva André , Willig Renata , Reyes Ana , Serpa Joana , Marconcin Priscila , Vieira Fernando , Soares Denise , Casanova Nuno
Published: June 2024

(1) Background: The popularity of motion-sensing computer-based games, like virtual reality (VR) exergames, is increasing among adolescents. However, their efficacy compared to conventional physical training methods remains unclear. This study investigated whether VR exergames produce effects on reaction time (RT) comparable to traditional tennis training in school-aged adolescents. (2) Methods: In total, 130 adolescents (mean age: 15.6 ± 2.0 years; 67 boys: 15.5 ± 2.2 years; 63 girls: 15.7 ± 1.8 years) were recruited in schools and assigned to one of three groups: VR exergame (G1, n = 39), tennis training (G2, n = 25), or control (G3, n = 66). Participants’ RTs were evaluated before and after the interventions. G1 engaged in VR exergames for 8 min, G2 underwent traditional tennis training for 30 min, and G3 did not participate in any physical activity. (3) Results: Our results indicated that in G3, girls exhibited slower RTs compared to boys (p < 0.0). No differences were observed in RTs when comparing G1 and G2. (4) Conclusions: Sex appeared to influence RT, with girls showing slower RTs than boys in G3. The findings suggest that VR exergames and traditional tennis training have similar impacts on RT. This indicates the potential of VR exergames as an alternative to conventional physical training for improving RT in adolescents.
Evaluation of Aerobic Propagation of Yeasts as Additional Step in Production Process of Corn Ethanol
Authors: Oliveira Matheus Ribeiro Barbosa , Douradinho Rafael Soares , Sica Pietro , Mota Layna Amorim , Pinto Alana Uchôa , Faria Tamires Marques , Baptista Antonio Sampaio
Published: June 2024

Yeast is one of the co-products of ethanol plants, which can be used as a nutritional supplement in animal feed due to its high protein content. Given the importance of yeast contribution to the nutritional properties of DDG (dried distillers’ grains), the aim of this study was to assess how different levels of aeration affect the biomass production and the quality of yeast providing new insights into yeast production, offering an alternative source of income for the corn ethanol industry. For this purpose, yeasts were grown in a fed-batch process, and different concentrations of aeration in the medium were tested, namely 0.5, 1.0, and 1.5 volume of air per volume of wort per minute (v v−1 min−1). At the end of the cellular biomass production process, yeasts grown with 0.5 (v v−1 min−1) aeration in the reactor showed higher biomass formation (19.86 g L−1), cellular yield (g g−1), and a lower formation of succinic acid (0.70 g L−1) and acetic acid (0.11 g L−1). Aeration influenced an increase of 1.0% in the protein content in yeast. In conclusion, lower levels of aeration in the yeast production process enables more efficient sugar utilization for biomass formation and is a potential strategy to increase the protein content and the commercial value of DDG.
Evaluating the Efficacy of Reconstruction: Systematic Review of Six-Strand Hamstring Autografts for Anterior Cruciate Ligament Reconstruction: Biomechanical and Clinical Outcomes
Authors: Vyacheslavovich Ondar Artysh , Vladimirovna Nikonova Alina , Bekzhan Dzhunusov , Ayanovich Khaizhok Konstantin , Goncharov Evgeniy , Koval Oleg , Bezuglov Eduard , Encarnacion Ramirez Manuel De Jesus , Montemurro Nicola
Published: June 2024

Introduction: Anterior Cruciate Ligament (ACL) injuries are a major concern in orthopedics, particularly affecting active individuals and often necessitating surgery. The incidence of ACL injuries is rising, especially in women, comprising half of knee joint injuries. These injuries, common in sports with pivoting actions, can lead to long-term joint issues like osteoarthritis. Advances in surgical methods and understanding of postoperative recovery are crucial for improving patient outcomes, with considerations for graft size, material, and reconstruction technique critical in the rehabilitation process. Material and Methods: A systematic review was conducted by searching PubMed, MEDLINE, and SCOPUS for studies from 2009 to 10 February 2024, focusing on “six-strand hamstring graft” outcomes in ACL reconstruction. Inclusion criteria were English publications on 6HS autografts’ biomechanical and clinical outcomes. Excluded were non-specific, BTB, or hybrid studies, and non-research articles. Out of 347 records, 9 were analyzed after rigorous screening and quality assessment. This review, emphasizing six-strand hamstring autografts, enriches orthopedic knowledge, particularly for ACL surgery. Results: This review evaluated studies on six-strand hamstring (6HS) autografts for ACL reconstruction, encompassing prospective, retrospective, and cadaveric studies with subjects ranging from 12 to 413. Findings indicate that 6HS autografts enhance knee stability and increase graft diameter, correlating with reduced graft failure rates and improved clinical outcomes, including high patient satisfaction and low re-injury rates. Rehabilitation varied, with recovery times quicker due to larger graft sizes, and most studies reported low complication rates, underscoring 6HS autografts’ efficacy in ACL surgery. Conclusions: Performing 6HS autografts in ACL reconstruction reveals that they offer improved knee stability and graft diameter, leading to better clinical outcomes. These autografts are associated with high patient satisfaction and low re-injury rates, suggesting their effectiveness in mimicking native ACL function and enhancing rehabilitation. However, research limitations highlight the need for further long-term, comprehensive studies.
The Systems Thinking Approach to Strategic Management
Authors: Kunc Martin
Published: June 2024

This paper presents a review of the field of systems thinking and strategic management The evolution of the areas of interest between systems thinking and strategic management follows similar patterns with more prescriptive developments occurring within the 1960s until 1980s; then, an increasing focus on emergence and transformation emerged in later years. From the review, there seems to exist synergies between multiple strands in Systems Thinking and Strategic Management. Suggestions to facilitate the interaction between both fields are proposed, considering the type of processes to generate strategies and the perspectives employed to visualize the organizations as systems. Hopefully, the paper can contribute to embedding systemic approaches to the strategic management of organizations and society.
SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV
Authors: Ruta Simona , Popescu Corneliu Petru , Matei Lilia , Grancea Camelia , Paun Adrian Marius , Oprea Cristiana , Sultana Camelia
Published: June 2024

Immunosuppressed individuals, such as people living with HIV (PLWH), remain vulnerable to severe COVID-19. We analyzed the persistence of specific SARS-CoV-2 humoral and cellular immune responses in a retrospective, cross-sectional study in PLWH on antiretroviral therapy. Among 104 participants, 70.2% had anti-S IgG antibodies, and 55.8% had significant neutralizing activity against the Omicron variant in a surrogate virus neutralization test. Only 38.5% were vaccinated (8.76 ± 4.1 months prior), all displaying anti-S IgG, 75% with neutralizing antibodies and anti-S IgA. Overall, 29.8% of PLWH had no SARS-CoV-2 serologic markers; they displayed significantly lower CD4 counts and higher HIV viral load. Severe immunosuppression (present in 12.5% of participants) was linked to lower levels of detectable anti-S IgG (p = 0.0003), anti-S IgA (p < 0.0001) and lack of neutralizing activity against the Omicron variant (p < 0.0001). T-cell responses were present in 86.7% of tested participants, even in those lacking serological markers. In PLWH without severe immunosuppression, neutralizing antibodies and T-cell responses persisted for up to 9 months post-infection or vaccination. Advanced immunosuppression led to diminished humoral immune responses but retained specific cellular immunity.
Lipid Nanoparticles Outperform Electroporation in Delivering Therapeutic HPV DNA Vaccines
Authors: Li Mingzhu , Liu Lei , Li Xiaoli , Li Jingran , Zhao Chao , Zhao Yun , Zhang Xiaopeng , He Panpan , Wu Xiaoyu , Jiang Siwen , Wang Xingxing , Zhang Xiujun , Wei Lihui
Published: June 2024

Therapeutic HPV vaccines that induce potent HPV-specific cellular immunity and eliminate pre-existing infections remain elusive. Among various candidates under development, those based on DNA constructs are considered promising because of their safety profile, stability, and efficacy. However, the use of electroporation (EP) as a main delivery method for such vaccines is notorious for adverse effects like pain and potentially irreversible muscle damage. Moreover, the requirement for specialized equipment adds to the complexity and cost of clinical applications. As an alternative to EP, lipid nanoparticles (LNPs) that are already commercially available for delivering mRNA and siRNA vaccines are likely to be feasible. Here, we have compared three intramuscular delivery systems in a preclinical setting. In terms of HPV-specific cellular immune responses, mice receiving therapeutic HPV DNA vaccines encapsulated with LNP demonstrated superior outcomes when compared to EP administration, while the naked plasmid vaccine showed negligible responses, as expected. In addition, SM-102 LNP M exhibited the most promising results in delivering candidate DNA vaccines. Thus, LNP proves to be a feasible delivery method in vivo, offering improved immunogenicity over traditional approaches.
Multimodal Blockade of the Renin–Angiotensin System in the Treatment of Cancer in Dogs Has Mild Adverse Effects in Some Dogs
Authors: Dittmer Keren E. , Wetzel Sarah , Odom Thomas , Munday John S. , Flatt Elizabeth A. , Wilson Ingrid J. , Hughes Catherine , Tan Swee T.
Published: June 2024

The renin–angiotensin system (RAS) is increasingly being recognized to play a role in the tumor microenvironment, promoting tumor growth. Studies blocking a single part of the RAS have shown mixed results, possibly due to the existence of different bypass pathways and redundancy within the RAS. As such, multimodal blockade of the RAS has been developed to exert more complete inhibition of the RAS. The aim of the present study was to assess the safety of multimodal RAS blockade in dogs. Five dogs (four with appendicular osteosarcoma, one with oral malignant melanoma) were treated with atenolol, benazepril, curcumin, meloxicam, and metformin. The dogs underwent clinical examination, blood pressure measurement, and hematology and serum biochemistry tests performed at 0, 1, 3, 6, 9, and 12 weeks, then every 3 months thereafter. End-of-life decisions were made by the owners. None of the dogs developed hypotension. One dog had intermittent vomiting during the 64 weeks it was on the trial. One dog had a one-off increase in serum SDMA(symmetrical dimethylarginine) concentration. Dogs were euthanized at weeks 3 (osteosarcoma), 10 (osteosarcoma), 17 (osteosarcoma), and 26 (oral malignant melanoma), and one dog was still alive at the end of the trial at 64 weeks (osteosarcoma). This is the first assessment of multimodal blockade of the RAS in dogs, and the results suggest it causes only mild adverse effects in some animals. The efficacy of the treatment was not assessed due to the small number of dogs. This pilot study allows for future larger studies assessing multimodal RAS blockade for the treatment of canine cancer.
Allogenic Follicular Fosterage Technology: Problems, Progress and Potential
Authors: Teng Mingming , Zhao Mengqi , Mu Bo , Lei Anmin
Published: June 2024

The allogeneic follicular fosterage (AFF) technique transfers cumulus–oocyte complexes (COCs) from pubertal female animals to the dominant follicles of adult female animals for further development, allowing the COCs to further develop in a completely in vivo environment. This article reviews the history of AFF and JIVET and their effects on oocyte and embryo development as well as freezing resistance. Improving the efficiency and reproducibility of AFF technology is crucial to its clinical application. This article discusses factors that affect the success rate of AFF, including differences in specific technical procedures and differences between pubertal and adult follicles. Designing standardized procedures and details to improve the synchronization of donor COCs and recipient follicle maturity and reducing the damage to COCs caused by follicular aspiration may be the direction for improving the success rate of AFF in the future.
MOTIVES OF “HUMILITY” AND “SPIRITUAL JOURNEY” IN THE ESSAY SERIES BY B.K. ZAITSEVA “ATHOS”
Authors: Yudnikova Alena A.
Published: June 2024

The article examines the interaction of the motives of “humility” and “spiritual journey” in the book by B.K. Zaitsev “Athos”. Their cycle-forming function is shown. The features of the artistic implementation of these motifs are revealed. The system of images used by the writer to represent the motives of “humility” and “spiritual journey” is reconstructed. It is proved that the poetics of these motifs is formed from many elements and includes impressionism in the depiction of pictures of nature, the use of symbols of Medieval literature, quoting lines from Holy Scripture and the writings of the Church Fathers. The work also traces the genetic connection of the motifs of “humility” and “spiritual journeying” with the ancient genre of walking. Particular attention is paid to identifying the value guidelines that determine the philosophical concept of the cycle. It is concluded that the motifs under consideration are further developed in the essay cycle “Valaam” and the tetralogy “Gleb’s Journey”.
LEXICAL EXPLICATION OF THE GEOCULTURAL BRAND YELETS IN THE TOURIST INTERNET DISCOURSE
Authors: Selemeneva Olga A. , Popova Olga P.
Published: June 2024

The article deals with the issue of linguistic means of representing geocultural images of territories in the online tourist discourse. Topicality of the work is due to a set of reasons: the cultivation of certain images of territories in the geocultural regional policy; the interest of scientists in analysing the linguistic features of online tourist discourse; the unexplored linguistic component of different geocultural brands. The subject of the study is the means of explication of the geocultural brand Yelets. The research material is texts posted on the sites of travel agencies and tour operators. The study found that in the online tourist discourse, the geocultural brand Yelets is represented by a set of linguistic means: an extensive system of onyms among which, oikonyms, oronyms, potamonyms, urbanonyms, ecclesionyms, anthroponyms, etc. are marked; some appellatives such as страж (guardian), сокровищница (treasury), музей (museum), воин (warrior), etc., attributive vocabulary; a number of phrases, including the otonymous adjective елецкий. It is noted that the semantic dominant of the texts is the asti onym Yelets, which is thematically, contextually and associatively connected with all other onyms, appellatives and characteristic vocabulary. The authors come to the conclusion that the system of linguistic means used, actualising a number of stereotypes, helps the addressee to form in its mind the image of the ancient provincial city in the core of Russia with a certain historical and cultural background.
PUBLIC ADMINISTRATION OF THE SULTANATE OF DELHI IN THE 13TH – 15TH CENTURIES (historical and legal review)
Authors: Gruzdev Vladislav V.
Published: June 2024

The article describes the system of public administration of the Sultanate of Delhi. Strong influence of Turkic tribal groups’ tradition on the political, legal and managerial culture of the Sultanate is noted. We consider the state of Delhi to be a theocratic monarchy, where the sultans’ power extended to all spheres of society. An important role in the administration was played by the Vizier and his department responsible for various aspects of state and political life. The article notes the important role of the departmental system among which, the central place was occupied by the departments of the army, Chancery, foreign relations and justice. The article highlights the place and role of the sultan’s court and the legislative body under the ruler in the official apparatus. It is indicated that the main element of administrative management included the iqta – lands transferred for service to certain persons. It is concluded that the public administration system organised by the Turkic peoples, despite a number of problems, had once been generally stable and helped integrate the northern Indian territories into the Muslim socio-cultural space.
‟FERRIS WHEEL”: FEMALE SOCIAL MEMORY OF THE EVERYDAY LIFE OF HYDRAULIC WORKERS IN SIBERIAN CHERYOMUSHKI IN THE 1970S
Authors: Pushkareva Natalya L. , Zhidchenko Alexander V.
Published: June 2024

The article is devoted to the analysis of female social memory about the life of the village of hydraulic builders and hydropower workers in Cheryomushki, Khakassia Autonomous Soviet Socialist Republic, in the 1970s. The authors consider their main scientific task to be a special study of women’s memories of the life of that time as more topical and representative, than the men’s ones, in the study of the history of everyday life. Correlating memory of life in a new township in the 1970s with the memory of women who lived and worked in similar cities built at hydroelectric power stations a decade and a half earlier (Volzhsky, Kakhovka, Kuybyshev), revealed a number of differences in the axiosphere of different generations of women, as well as the severity of the reaction of residents of Siberian Cheryomushki to social transformations in Russia at the late 1980s and the 90s. Their local symbol was the destruction of the Ferris wheel, which had been built under Soviet rule in a local park, – a sign of lost hopes.
COMMUNIST PARTY’S AND POLITICS’ ELITES IN THE TRANSFORMATION OF MONGOLIAN SOCIETY IN THE 1920s TO 30s
Authors: Batunaev Eduard V.
Published: June 2024

This study shows the multifactorial process of formation of new communist and political elite in Mongolia in the 1920s and 30s during the hardest period of the struggle for sovereignty and the formation of true Mongolian state. The author focuses on the analysis of domestic political and foreign policy factors influencing the development of the basic principles and mechanisms of the formation of the Mongolian Communist Party’s and politics’ elite and its participation in the process of transformation of traditional Mongolian society based on the socialist modernisation model. The characteristics of the process of formation of the Mongolian communist and political elite from the very first revolutionary circles of Mongolia People’s Party to the fundamental measures of the country’s socialist reorganisation are given. Particular attention is paid to the formation of a “tactical alliance” at the initial stage of the revolutionary process, the internal political struggle in the ranks of the Mongolian communist and political elite in carrying out fundamental social changes and the transformation of Mongolian society in the period of the 1920s-40s. On the basis of archival material and taking into account the achievements of modern Russian and foreign historiography, problematic and key issues of Russian historiography of the process of formation of the political elite and the transformation of the socialist model of the socialist model in Mongolia in the 1920s-30s are considered. The author concluded that the period of the 1920s and 30s, the struggle between old and new social forces, the formation of a new communist and political elite unfolded against a very unique background characterised, on the one hand, by the desire for national unity, the revival of Mongolian statehood, and on the other hand, by the choice of the optimal model of social development in those historical conditions.
G.J.R. HAUPTMAN’S LATE DRAMA ‟IPHIGENIE IN AULIS” IN ASPECT OF MODERNIST DISCOURSE
Authors: Sklizkova Alla P.
Published: June 2024

The article examines the work of Gerhard Johann Robert Hauptmann in the context of the problem of self-understanding associated with the continuous process of creative comprehension of his works created earlier. The aim of this work is to identify the world-wide modernist position of Hauptmann, derived from his anthropological logic. The research tasks correspond to this: to show the process of formation of new forms of subjectivity in the dramatist’s work; to substantiate Hauptman’s internal movement to self-understanding; to review his drama ‟Iphigenie in Aulis”, to see how a new conception of being is emerging in the depths of the former artistic system. The analysis reveals the modernist tendencies in Hauptmann’s work, associated with the creative process of individual consciousness – the renewal, reworking and redefinition of impressions from previously read texts of pen’s colleagues (in this case Plato, Jakob Böhme, Sigmund Freud and Ricarda Huch) and the reinterpretation of their own works in this regard. Hauptman, expanding his horizon of study, gives the goddess Hecate, whom his drama ‟Iphigenie in Delphi” is referred to, the creative power of Eros and presents these chthonic powers in the work ‟Iphigenie in Aulis” as a positive first. The heroine, having grasped this first principle in indestructible unity, passes a difficult path of spiritual enlightenment, acquires a new birth – the immortality the elderly writer thought in his consciousness.
A model for the formation of ethnic and cultural identity of rural school students in the process of project activities
Authors: Krasavin Nikita D.
Published: June 2024

The article examines the problems of modern Russian education related to the formation of the ethno-cultural identity of students, defines a model for the formation of the ethno-cultural identity of students in rural schools in the process of project activities. A theoretical analysis of the concept of ethno-cultural identity is carried out, a comparative characteristic of such categories as national identity, social identity, ethnic identity, socio-cultural identity and ethno-cultural identity. The structure of the phenomenon of ethnocultural identity is determined, in which value-oriented, cognitive, emotional-evaluative and behavioral components are distinguished. The article analyzes the mass experience of the formation of ethnocultural identity among children and youth, which at this stage of the development of pedagogical practice is characterized by the lack of systematic activities aimed at the formation of ethnocultural identity of students in institutions of basic and additional education, as well as fragmentation. A model of the formation of the ethno-cultural identity of rural school students in the process of project activity is proposed and the main substantive stages of its implementation are determined.
Features of the value-semantic sphere of personality in students prone to using psychoactive substances
Authors: Kagermazova Laura T. , Masaeva Zarema V.
Published: June 2024

The article is devoted to the study of the value-semantic sphere of the personality of students who are prone to the use of psychoactive substances. The importance of timely organization of corrective work to overcome addictive behavior is noted. The article examines the factors determining the occurrence of dependent behavior, the classification of motives for the formation of dependent forms of personality behavior in college age. Theoretical and methodological approaches to the study of the emergence of addictive forms of personality behavior are considered. The empirical part of the study describes the structure, methods and results of the study of the student's personality attitude to psychoactive substances. The relationship between value-semantic characteristics and attitude to psychoactive substances has been established.
Performing a multi-stage mathematical information task "Framing the Mandelbrot set of families of polynomials of the third degree and remarkable curves"
Authors: Smirnova Elena Sa. , Sekovanov Valery S. , Rybina Larisa B. , Shchepin Roman Al.
Published: June 2024

In this article, within the framework of a multi-stage mathematical information task, the methodology for students to study Mandelbrot sets and frames of Mandelbrot sets of a family of polynomials of the third degree is indicated. Algorithms for constructing these sets in various environments are described. The connections of the frames of the Mandelbrot set with remarkable curves are studied: lemniscate, epicycloid and others. This work is aimed at developing students' creativity and research competencies. When performing a multi-stage mathematical and informational task, the student acts as a mathematician, programmer and computer artist, which is aimed at developing his creativity and increasing motivation for mathematics and programming.
Activity and involvement of college students in extracurricular activities in order to develop social activity
Authors: Nalyotova Natalya Y. , Makhankova Natalia I.
Published: June 2024

The article discusses the role of social activity of college students, levels of social activity and their signs are considered. The results of the study of revealing the percentage of participation of students of different courses in various extracurricular activities in order to track the dynamics of social activity levels are presented. This is due to the fact that modern society in the process of its continuous development requires educational institutions to train highly qualified specialists capable of independent decision-making, ready for positive transformations in society, proactive. It is revealed that the solution of this problem is maximally promoted by the development of students' social activity.
IDENTIFYING AND ANALYSING BASE TREND IN CORPORATE UNIFORM DESIGN
Authors: Denisova Olga I. , Denisov Artem R.
Published: June 2024

The article examines the problem of identifying key trends in the development of the concept of corporate uniform in an organisation based on information about successfully implemented projects in various professional fields. For this purpose, an algorithm for applying data analysis methods in practical activities CRISP-DM was used, which includes six typical stages: understanding business goals, initial study of data, data preparation, modeling, evaluation and implementation. For each stage, methods (mathematical, expert) for processing data to identify trends are defined. The result of applying the proposed methodology is a visual presentation of data on identified trends in uniform design, including in the format of temperature maps, allowing a specialist in the field of costume design to reasonably interpret them and extrapolate the identified trends into the future of corporate fashion and corporate identity.
Self-compassion as a resource in the parenting role
Authors: Żmuda Agnieszka
Published: June 2024

The aim of the article is to present self-compassion as a resource in the context of performing a parental role and its importance for interactions with a child. The study included an analysis of existing data. A meta-analysis of concepts related to the main variable described in the article and their relationships with parenting was performed. Self-compassion, as a variable conducive to a person’s mental well-being and coping with difficulties, is an important factor that helps in fulfilling parental roles, supporting the child’s development and building a healthy relationship with the child. Source analyzes allowed to show self-compassion as an important resource and a factor supporting coping with negative affect, difficulties, as well as supporting the parent’s psychological functioning. It is an important area of human development and adaptability–also in the role of a parent. Theoretical analyzes presented in this study lead to recommendations for research on the development of self-compassion among parents as a variable supporting their functioning.