bluuebunny/crossref_metadata_2025 huggingface dataset:
The Gut Microbiome Composition Is Altered in Long-standing Type 1 Diabetes and Associates With Glycemic Control and Disease-Related Complications
Authors: van Heck Julia I.P. , Gacesa Ranko , Stienstra Rinke , Fu Jingyuan , Zhernakova Alexandra , Harmsen Hermie J.M. , Weersma Rinse K. , Joosten Leo A.B. , Tack Cees J.
Published: June 2022

OBJECTIVE

People with type 1 diabetes are at risk for developing micro- and macrovascular complications. Little is known about the gut microbiome in long-standing type 1 diabetes. We explored differences in the gut microbiome of participants with type 1 diabetes compared with healthy control subjects and associated the gut microbiome with diabetes-related complications.

RESEARCH DESIGN AND METHODS

Microbiome data of 238 participants with type 1 diabetes with an average disease duration of 28 ± 15 years were compared with 2,937 age-, sex-, and BMI-matched individuals. Clinical characteristics and fecal samples were collected, and metagenomic shotgun sequencing was performed. Microbial taxonomy was associated with type 1 diabetes–related characteristics and vascular complications.

RESULTS

No significant difference in the α-diversity of the gut microbiome was found between participants with type 1 diabetes and healthy control subjects. However, 43 bacterial taxa were significantly depleted in type 1 diabetes, while 37 bacterial taxa were significantly enriched. HbA1c and disease duration explained a significant part of the variation in the gut microbiome (R2 > 0.008, false discovery rate [FDR] <0.05), and HbA1c was significantly associated with the abundance of several microbial species. Additionally, both micro- and macrovascular complications explained a significant part of the variation in the gut microbiome (R2 > 0.0075, FDR < 0.05). Nephropathy was strongly associated with several microbial species. Macrovascular complications displayed similar associations with nephropathy.

CONCLUSIONS

Our data show that the gut microbiome is altered in people with (long-standing) type 1 diabetes and is associated with glycemic control and diabetes-related complications. As a result of the cross-sectional design, the causality of these relationships remains to be determined.
Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach
Authors: Tricò Domenico , McCollum Sarah , Samuels Stephanie , Santoro Nicola , Galderisi Alfonso , Groop Leif , Caprio Sonia , Shabanova Veronika
Published: June 2022

OBJECTIVE

In a large, multiethnic cohort of youths with obesity, we analyzed pathophysiological and genetic mechanisms underlying variations in plasma glucose responses to a 180 min oral glucose tolerance test (OGTT).

RESEARCH DESIGN AND METHODS

Latent class trajectory analysis was used to identify various glucose response profiles to a nine-point OGTT in 2,378 participants in the Yale Pathogenesis of Youth-Onset T2D study, of whom 1,190 had available TCF7L2 genotyping and 358 had multiple OGTTs over a 5 year follow-up. Insulin sensitivity, clearance, and β-cell function were estimated by glucose, insulin, and C-peptide modeling.

RESULTS

Four latent classes (1 to 4) were identified based on increasing areas under the curve for glucose. Participants in class 3 and 4 had the worst metabolic and genetic risk profiles, featuring impaired insulin sensitivity, clearance, and β-cell function. Model-predicted probability to be classified as class 1 and 4 increased across ages, while insulin sensitivity and clearance showed transient reductions and β-cell function progressively declined. Insulin sensitivity was the strongest determinant of class assignment at enrollment and of the longitudinal change from class 1 and 2 to higher classes. Transitions between classes 3 and 4 were explained only by changes in β-cell glucose sensitivity.

CONCLUSIONS

We identified four glucose response classes in youths with obesity with different genetic risk profiles and progressive impairment in insulin kinetics and action. Insulin sensitivity was the main determinant in the transition between lower and higher glucose classes across ages. In contrast, transitions between the two worst glucose classes were driven only by β-cell glucose sensitivity.
Mário Pedrosa entrevista Benjamin Péret
Authors: Karepovs Dainis
Published: June 2022

Esta entrevista de Mário Pedrosa com o poeta surrealista francês Benjamin Péret2,publicada em 17 de novembro de 1928, foi recentemente redescoberta perdidanas páginas de um jornal paranaense. A Revista Aurora a divulga com seus leitoresdevido à relevância do texto.
Como a História condiciona nossas experiências?
Authors: Gonzaga Guilherme Balduino
Published: June 2022

O presente ensaio busca examinar como a História modela a percepção dos indivíduos e se apresenta enquanto solo constitutivo de nossas experiências. Procuramos entender, portanto, o que significa dizer que a forma como percebemos o mundo ao nosso redor é condicionado historicamente. Com essa finalidade, utilizaremos majoritariamente da interpretação que o filósofo Paulo Arantes, no seu primeiro livro publicado, em 1981, de título Hegel – A ordem do tempo, tem do mais famoso idealista alemão, G.W.F. Hegel.
METODE DISKUSI UNTUK MENGEMBANGKAN KEAKTIFAN DAN HASIL BELAJAR KOGNITIF MATEMATIKA SISWA PADA PEMBELAJARAN DARING
Authors: Engelina Engelina , Dirgantoro Kurnia Putri Sepdikasari
Published: June 2022

Activeness and cognitive learning outcomes of students are important things to achieve success in the learning process. However, the fact is that the activeness and cognitive learning outcomes of students in a private high school in Tomohon, North Sulawesi are still not optimal in the online learning process carried out by the author. This is because the teacher is less precise in choosing and implementing learning methods. To overcome this, the author uses the discussion method in online learning. This research using the descriptive qualitative method aims to describe the implementation of the discussion method in developing the activeness and cognitive learning outcomes of students in online learning. The instruments in this study consisted of the teacher's reflection journal, lesson plans, and test of students' cognitive learning outcomes. With the research subject of class XI IPA 2 students, totaling 27 students. The results showed that there was a development in students' activeness and cognitive learning outcomes after applying the discussion method. In conclusion, a discussion process such as dividing students into small groups can provide broad opportunities for students to be active during learning so that students can be directly involved in solving problems and lead to optimal learning outcomes.
KEPUASAN MAHASISWA KEDIRI TERHADAP PENGGUNAAN MODEL BLENDED LEARNING PADA MATA KULIAH STATISTIK SAAT PANDEMI COVID-19
Authors: Safa'udin Muhamad , Yannuansa Nanndo
Published: June 2022

The purpose of this study was to compare the level of student satisfaction with the use of the blended learning model as a learning media for course statistics during the Covid-19 pandemic for IAI Tribakti Kediri students with students from several Kediri private universities. This study uses a quantitative approach with comparative descriptive techniques. The subjects of this study were 130 students of IAI Tribakti Kediri with students from several Kediri private universities. The data collection technique in this study used a questionnaire. The data analysis technique in this study used descriptive analysis and independent sample t test. From the results of data analysis, the tcount value is 0.089 < 1.657 t5%: 128, this means that there is no difference in the level of student satisfaction with the use of the blended learning model as a learning medium for statistics courses during the Covid-19 pandemic at IAI Tribakti Kediri students and students from several universities. private Kediri. Where 58% of students showed a good response to the use of blended learning.
ASSESSING THE PERFORMANCE OF UNITS FOR THE SYNTHESIS OF OLIGODYNAMIC SOLUTIONS FOR WATER TREATMENT
Authors:   Vyatka State University, Belyaev Andrey , Kuts Elena ,   Saint Petersburg State University of Architecture and Civil Engineering, Shabalin Vladimir ,   Saint Petersburg State University of Architecture and Civil Engineering
Published: June 2022

Introduction: Fresh water suitable for water supply has been depleted due to production activities. Thus, closed water supply cycles are required at civil infrastructure facilities. The quality of water must meet the requirements on its use for various purposes. It is common knowledge that water is essential in providing adequate health and sanitary conditions for the public. Therefore, issues of water treatment remain in the focus of researchers. Water disinfection is one of the mandatory methods used in water purification and treatment. Currently, chlorination is still the main technology for water disinfection. However, it is responsible for toxic, carcinogenic, and other types of negative effects on the human body. In this paper, we consider the use of oligodynamic solutions as a new, rapidly-developing direction in water treatment. In the course of our study, we addressed a method of swimming pool water disinfection using units of oligodynamic synthesis and examined the results of treated water quality analyses. Methods: The study was based on the statistical analysis of water quality indicators in pools with water treated with silver and copper ions. The analysis made it possible to determine the hygienic safety and reliability of products. To assess hygienic safety and reliability, we analyzed the composition and properties of the product (oligodynamic solution) as well as the composition and concentration of impurities in pool water and determined if the disinfecting properties of water are preserved and proper levels of copper and silver ions (not exceeding MAC) in pool water are maintained. Results: The paper provides a rationale for procedures to analyze and determine the safety and reliability of small-scale units producing disinfection solutions to ensure optimal swimming conditions in swimming pools. Discussion: The obtained results indicate that it is expedient to apply oligodynamic water treatment to ensure the hygienic safety and reliability of swimming pools. The technology suggested fully meets the requirements of sanitary regulations on water quality.
EFL secondary school students' experiences in performing ideas using Prezi presentation
Authors: Jamilah Nur , Mustofa Mutmainnah , Hariyanto Sugeng , Zahroh Fatimatus
Published: June 2022

Using sophisticated technology in EFL has been a source of considerable debate. As a part of the Web 2.0 movement, Prezi lets users generate, produce, and preserve virtual demonstrations. While a substantial study has been conducted on the benefits and downsides of utilizing Prezi presentations, there is scarce research on students' experiences with using Prezi. The study aims to look at pupils' perspectives on using Prezi in learning English to fill the gap. Twenty students from a private secondary school in Mojokerto, Indonesia, were examined. This exploratory qualitative case study used a purposive sampling strategy. They answered ten interview questions, which the researchers examined using content analysis. The findings revealed that students' experiences using Prezi and making Prezi demonstrations could be divided into four primary topics: serviceability, effectiveness, design, and hindrances. Using Prezi, students experienced producing more interactive visuals for their production than standard PowerPoint slides. In line with this study, Prezi's revolutionary features transform the report from a monotonous and direct way into a fascinating, stunning, practical, and nonlinear style. The findings of this study, in practice, demand the implementation of academic tutorials for classroom teachers to construct their core principles of teaching utilizing the Prezi presentation.
Mobilya Sektörü Çalışanlarında İş Kazası ve Meslek Hastalıklarının İncelenmesi Üzerine Bir Araştırma
Authors: AŞKIN Ayşin , ÖZTÜRK Ömer Faruk
Published: June 2022

Bu çalışma mobilya sektörü çalışanlarında iş kazası ve meslek hastalıklarının incelenmesi amacıyla gerçekleştirilmiştir. Çalışma verilerinin elde edilmesinde anket yöntemi uygulanmıştır (280 anket çalışma kapsamına alınmıştır). Veri girişi ve analizi için SPSS istatistiksel 20,0 paket programı kullanılmıştır. Tanımlayıcı verilerin sunumunda ortalama, standart sapma, frekans, yüzde, minimum ve maksimum değerleri kullanılmıştır. Bağımlı, bağımsız değişkenlerin tek değişkenli analizinde Ki-Kare testi kullanılmıştır. Çalışanların kişisel koruyucu ekipmanlarını düzenli olarak kullanmadıkları, dikkatsizliğin en büyük kaza sebebi olduğu anlaşılmıştır. En fazla kesim işlemi sırasında kaza geçirdikleri belirlenmiştir. Çalışma sonucunda yaş, gelir durumu ve sağlık sorunları ile iş kazası geçirme durumu arasında anlamlı bir ilişki olduğu tespit edilmiştir
USING SIGIL TO MAKE AN ELECTRONIC MODULE AND ITS PRACTICAL VALUE
Authors: Jannah Jannah , Kaspul Kaspul , Utami Nurul Hidayati
Published: June 2022

Electronic modules are teaching materials, that arranged systematically, covering competencies that will be mastered by students and equipped with an attractive appearance. Sigil is an e-book maker with an epub output format. This study aims to describe practicality of the electronic module using Sigil application oriented the scientific approach to environmental change materials for high school level. This type of research is Research and Development (R&D) which refers to the 4-D model. 4-D model consist 4 main stages; define, design, develop and disseminate. The subjects in this study were 9 students of SMAN 7 Banjarmasin. The instrument was a questionnaire. The results of practicality test obtained an average percentage of 88.54% (very practical), 88.00% in the display aspect (very good), 92.44% in the material presentation aspect (very good), and 85.18% in the benefits aspect (very good). Overall, it is very practical and can be used by students.
VALIDITY OF 3D PAGEFLIP POCKET BOOK CONTAINING POACEAE SPECIES IN GALAM VEGETATED SWAMP, BATI-BATI DISTRICT
Authors: Pohan Vika Wulansari , Dharmono Dharmono , Riefani Maulana Khalid
Published: June 2022

Species of Poaceae may be used as mastering objects, based on local potential, as learning resources, thats in accordance with technological developments, making it into 3D pageflip based pocket book. A valid pocket book, as learning resources, can be defined if it has been validated by experts in field. Validation role to assess the prototype, and eligible for more developmental phases. The aim of this research is to determine the validity of the pocket book, which contains material about Poaceae species in galam vegetated swamps. This pocket book is in the form of a 3D pageflip. This development uses Tessmer's formative evaluation model. The value of validity is determined by 2 experts. The results of the study confirm that the product that has been developed is very valid, especially for expert consequences of 93.42%.
POCKET BOOK ON SELUANG FISH DIVERSITY AS ENRICHMENT MATERIAL FOR VERTEBRATE ZOOLOGY COURSE
Authors: Hayati Nida , Halang Bunda , Zaini Muhammad
Published: June 2022

Rivers are the main habitat for fish groups, including Seluang fish of the genus Rasbora. Existence of these fish become a potential content for local potential-based biology teaching materials. Teaching materials with this content can be enriched. One form of supplementary teaching materials that can be developed based on local potential is a pocket book. This development uses Borg & Gall method. The results showed three types of fish, namely Rasbora argyrotaenia (Seluang Langkai), Rasbora tornieri (Seluang Kuning), and Rasbora dusonensis (Seluang Batang). Based on the pocket book validity test, it was declared very valid, with a value of 91.93%, dan the results of readability test by 6 students obtained 91.40%, pocket book has very good criteria.
USING FLIPBOOK MAKER TO CREATE SCIENCE PROCESS ORIENTED ELECTRONIC HANDOUT
Authors: Rusdiana Cahyani , Kaspul Kaspul , Utami Nurul Hidayati
Published: June 2022

E-handout is teaching material that are displayed electronically. One of the software used for e-handout development is Flipbook Maker. Mentioning the development of information technology, plus the proliferation of distance education, then the development of e-handout is one of the most appropriate choices. Moreover, its development is accompanied by Science Process Skills, so this development is carried out. This development research consists of 4 stages; define, design, develop and disseminate. This article contains research results in the form of values and descriptions of practicality test results. The research subjects were 9 practitioners from the State High School 8 Banjarmasin. The results of the study show that the e-handout is practical in the display aspect (score 88.88%), practical in the presentation aspect (88.00%), and practical also in the benefit aspect (88.21%). In conclusion, a product that is practically in line with expectations has been produced.
IMPLEMENTATION OF ONLINE PRACTICUM AT BIOLOGY EDUCATION STUDY PROGRAM, UNIVERSITAS AHMAD DAHLAN
Authors: Aprilia Nani , Irawati Hani
Published: June 2022

COVID-19 pandemic has changed the order of people's lives, and is a factor that has a major influence on learning, one of which is biology practicum at the university level. This study aims to evaluate the online biology practicum in the Biology Education Study Program, Universitas Ahmad Dahlan. This study uses a stake evaluation model. Determination of sample using the Slovin method and obtained 132 students. Collecting data by observation and questionnaires. Descriptive quantitative data analysis. Based on the findings, it is known that in the aspects of preparation and planning; preparation of practicum plan sheets, practicum rules, and practicum implementation instructions; categorized as very good. In the aspect of implementation, it is categorized as good, and learning outcomes are categorized as good.
Novaya strategiya poiska gormonal'noj terapii proliferativnyh processov endometriya u pacientok v postmenopauze
Authors: Савельева Г. М. , Бреусенко В. Г. , Карева Е. Н. , Голухов Г. Н. , Гуторова Д. С. , Овчинникова А. В. , Ивановская Т. Н. , Щербатюк К. В.
Published: June 2022

Prichiny neeffektivnosti gormonal'noj terapii proliferativnyh processov endometriya (PPE) v postmenopauze ostayutsya neyasnymi. Vliyanie gormonal'noj terapii PPE na aktivnost' immunnoj sistemy dostatochno ne izucheno. Cel'yu raboty bylo na osnovanii rezul'tatov issledovaniya ekspressii genov receptorov estradiola i progesterona v tkani endometriya, kletkah mononuklearnoj frakcii perifericheskoj krovi (MNFK) opredelit' celesoobraznost' i vozmozhnost' naznacheniya gormonal'noj terapii PPE u pacientok v postmenopauze. Obsledovali 92 pacientki v postmenopauze s PPE: s zhelezisto-fibroznymi polipami — 37; s giperplaziej bez atipii (GE) — 7; atipicheskoj giperplaziej (AGE) — 8; umerennodifferencirovannoj adenokarcinomoj — 31; vysokodifferencirovannoj adenokarcinomoj — 9. V MNFK i obrazcah tkani endometriya issledovali ekspressiyu ER⍺, ERß, mER, PRA, PRB, mPR, PGRmC1 metodom RT-PCR. V eksperimente opredelyali izmenenie receptornogo profilya MNFK posle inkubacii kletok s progesteronom i mifepristonom u pacientok s polipami endometriya i zdorovyh zhenshchin. Pri analize rezul'tatov v tkani GE obnaruzhen vysokij uroven' ERα, ERβ, PRA, PRB, mPR, PGRmC1. V MNFK pri AGE vyyavlen vysokij uroven' mER, ER⍺, PRA. Eto mozhet svidetel'stvovat' o podavlenii funkcii monocitov, makrofagov, T-limfocitov i natural'nyh killerov. Pri adenokarcinome endometriya receptornyj transkriptom v MNFK ne narushen, chto mozhet oznachat' razvitie avtonomnosti opuholi. V issledovanii in vitro mifepriston snizhaet ekspressiyu ER⍺, ERß, mPR, PGRmC1, PRA, PRB v MNFK u pacientok s polipami endometriya. Na nash vzglyad, eto niveliruet negativnoe dejstvie polovyh steroidnyh gormonov na immunokompetentnye kletki.
Pengaruh Stunting pada Kognitif Anak Usia Dini
Authors: Nazidah Milla Diah Putri , Fauziah Rida , Hafidah Ruli , Jumiatmoko Jumiatmoko , Nurjanah Novita Eka
Published: June 2022

Stunting is a condition in which children experience growth disorders that make a child's height shorter than his age, stunting is due to severe nutritional status over time. Early childhood’s stunting may influence various aspects of a child's development, especially in cognitive aspects. There is a significant link between stunting and child cognitive development. This relates to the maturity of the central nerve organ (brain) which with the ability of a child requires balanced nutritional intake. Therefore, stunting to early childhood children is closely related to cognitive abilities. The study used literature study methods by analyzing relevant research results. The purpose of this study is to know the correlation between stunting to premature cognitive and cognitive effects in cognitive aspects. With this study it is expected that stunting prevention efforts in children's early ages will be possible through roles between teachers, parents, and society institutions from the womb to the birth of children.
PENGARUH FAKTOR MAKROEKONOMI TERHADAP PERTUMBUHAN EKONOMI INDONESIA PERIODE 2018-2020
Authors: Kusumastuti Anggit Dyah , Mutiasari Annisa Indah , Paningrum Destina , Cahyani Rusnandari Retno
Published: June 2022

Penelitian ini bertujuan mengetahui pengaruh faktor fundamental makroekonomi yang meliputi inflasi, nilai tukar rupiah dan tingkat suku bunga SBI terhadap pertumbuhan ekonomi Indonesia sebelum dan selama pandemi covid-19. Jenis penelitian adalah penelitian deskriptif dengan pendekatan kuantitatif. Penentuan sampel berdasarkan data time series triwulan periode Januari 2018 sampai Desember 2020 dengan menggunakan metode sampling jenuh, yaitu sebanyak 12 sampel. Hasil uji simultan (uji F) menunjukkan bahwa inflasi, nilai tukar dan suku bunga secara simultan berpengaruh terhadap pertumbuhan ekonomi Indonesia. Hasil uji parsial (uji t), untuk variabel inflasi berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi Indonesia sebelum dan selama pandemi covid-19. Sedangkan, variabel nilai tukar Rupiah dan tingkat suku bunga SBI berpengaruh negatif tetapi tidak signifikan terhadap pertumbuhan ekonomi Indonesia. Upaya dalam mengendalikan inflasi, menstabilkan nilai tukar dan suku bunga melalui pengoptimalan penggunaan produk dalam negeri, perbaikan kinerja ekspor, seperti penurunan tarif ekspor dan pembatasan impor barang.
Analisis Tingkat Pengetahuan dan Sikap Masyarakat Terhadap Obat Generik di Wilayah Purwokerto Utara
Authors: Kartikaningrum  , Pratiwi Hening , Mustikaningtias Ika
Published: June 2022

Obat generik memiliki efektivitas serta hasil klinis yang sama dengan obat bermerek. Akan tetapi peredaran obat generik di Indonesia relatif rendah. Hal ini dapat dipengaruhi oleh pengetahuan dan sikap masyarakat terhadap obat generik. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan dan sikap masyarakat serta hubungan antara karakteristik dengan tingkat pengetahuan dan sikap masyarakat terhadap obat generik. Penelitian menggunakan desain cross sectional study dengan sampel berjumlah 385 responden yang terdaftar sebagai masyarakat Purwokerto Utara. Instrumen penelitian menggunakan kuesioner tingkat pengetahuan dan sikap. Analisis data menggunakan chi-square. Tingkat pengetahuan masyarakat terhadap obat generik sebagian besar kurang (56,4%). Sebanyak 75,8% responden memiliki sikap positif terhadap obat generik. Terdapat hubungan signifikan antara jenis kelamin (p=0,025), pendidikan (p=0,018) dengan tingkat pengetahuan terhadap obat generik, namun pada aspek usia (p=0,765) dan pekerjaan (p=0,121) tidak terdapat hubungan signifikan. Tidak terdapat hubungan signifikan antara jenis kelamin (p=0,365), usia (p=0,403), pendidikan (p=0,149), dan pekerjaan (p=0,159) dengan sikap masyarakat terhadap obat generik. Dapat disimpulkan sebagian besar masyarakat Purwokerto Utara memiliki pengetahuan kurang, namun bersikap positif terhadap obat generik. Karakteristik yang memiliki hubungan dengan tingkat pengetahuan yaitu jenis kelamin dan pendidikan. Tidak ada karakteristik yang memiliki hubungan dengan sikap masyarakat terhadap obat generik. Diperlukan peran tenaga kesehatan untuk edukasi dan promosi mengenai obat generik untuk meningkatkan tingkat pengetahuan masyarakat terhadap obat generik
THE CHAMELEON’S BLUSH AND THE POETIC IMAGINATION FROM SHAKESPEARE TO KEATS
Authors: SELL Jonathan P. A.
Published: June 2022

The Chameleon’s Blush and the Poetic Imagination from Shakespeare to Keats. When English Romantic poet John Keats likened William Shakespeare to a chameleon, far from being original, he was tapping into a venerable tradition of drawing analogies between human beings and the colour-changing reptile. In literary criticism, the analogy is usually taken to refer to poetic indeterminacy; in sociopsychology, to conscious or unconscious, opportunistic versatility of identity. This study traces the evolution of the polyvalent chameleon trope from the zoological treatises of antiquity, through wonder literature and Renaissance and early modern works on psychology and witchcraft, to Shakespeare’s plays. It shows more specifically how the chameleon came to acquire an imagination and how that imagination was, on the one hand, instrumental in prompting the sort of inter-subjective absorption Keats emblematised in the blush, and, on the other, projective in a sense akin to Hazlitt’s own theory of the imagination. As a result, new light is thrown not only onto specific features of Shakespeare’s art and Romantic poetics, but also onto past conceptions of the imagination and the generative role of zoological analogy in their formulations.
Article history: Received 13 December 2021; Revised 28 April 2022; Accepted 4 May 2022; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Cameleonul roșind, imaginația poetică de la Shakespeare la Keats. Atunci când poetul romantic John Keats l-a asemuit pe William Shakespeare unui cameleon, departe de a fi original, el recurgea la o venerabilă tradiție de a trasa analogii între oameni și reptila ce își poate schimba culoarea. În critica literară, analogia e de obicei înțeleasă ca referindu-se la nedeterminarea poetică; în socio-psihologie, la versatilitatea oportunistă a identității, conștientă ori inconștientă. Studiul de față urmărește evoluția tropului cameleonului polivalent de la tratatele de zoologie din antichitate, prin literatura de mistere și opere de psihologie și despre vrăjitorie renascentiste și din modernitatea timpurie, până la piesele lui Shakespeare. Lucrarea arată în mod specific modul în care cameleonul a ajuns să capete o imaginație și cum aceasta a fost, pe de o parte, un instrument în declanșarea acelui tip de absorbție inter-subiectivă pe care Keats a emblematizat-o în actul de a roși, și, pe de altă parte, proiectivă într-un sens apropiat teoriei asupra imaginației a lui Hazlitt. Ca rezultat, lucrarea pune într-o nouă lumină nu doar trăsăturile artei lui Shakespeare și poetica romantică, dar și concepțiile anterioare asupra imaginației și asupra rolului generativ al analogiei zoologice în formulările acestora.
Cuvinte-cheie: imaginație, cameleon, William Shakespeare, John Keats, a roși
POUR UNE MÉTAMORPHOSE DU LIBERTIN OU LE SYNDROME DE L’EXTRA-TERRITORIALITÉ CHEZ MILAN KUNDERA ET ÉRIC-EMMANUEL SCHMITT
Authors: BARTOȘ Bianca-Livia
Published: June 2022

A Metamorphosis of the Libertine or the Extra-Territoriality Syndrome in the Works of Milan Kundera and Éric Emmanuel Schmitt. This research aims to discuss the question of an ostensible metamorphosis of the libertine typology, as it is presented in the work of two contemporary writers, Milan Kundera and Éric-Emmanuel Schmitt. The first is the case of Tomas in The Unbearable Lightness of Being, published in 1984, first in Czech and, very soon afterward, in a French translation at Gallimard. On the other hand, we will analyze the same subject of an inherent metamorphosis caused by the extra-territoriality in The Elixir of Love, the epistolary novel of Éric Emmanuel Schmitt, published thirty years later, in 2014.
Article history: Received 5 January 2022; Revised 2 April 2022; Accepted 5 May 2022; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Către o metamorfoză a libertinului sau sindromul extrateritorialității la Milan Kundera și Éric Emmanuel Schmitt. Această lucrare își propune să discute problema unei metamorfoze aparente a tipologiei infidelului, așa cum este prezentată în opera a doi scriitori contemporani, Milan Kundera și Éric-Emmanuel Schmitt. În primul rând, este cazul lui Tomas în Insuportabila ușurătate a ființei, publicat în 1984 mai întâi în cehă și foarte curând în traducere franceză la editura Gallimard. Pe de altă parte, vom analiza același subiect al unei metamorfoze cauzate de extrateritorialitate în Elixirul dragostei, romanul epistolar al lui Éric Emmanuel Schmitt, publicat treizeci de ani mai târziu, în 2014.
Cuvinte-cheie: metamorfoză, libertin, infidel, teritorialitate, (de)filiație
NATURE-TRANSCENDENCE AND SELF-NATURE RELATIONS IN SANDOR WEÖRES’S POEMS
Authors: SZILVESZTER László Szilárd
Published: June 2022

Nature-Transcendence and Self-Nature Relations in Sándor Weöres’s Poems. In Sándor Weöres’s poems flora and fauna are not only a decoration, serving as an allegorical/metaphorical background for the representation of the self’s alienation and for the 20th century experience of a chaotic universe, but rather the reality of beings independent of subjective consciousness. This reality carries the already forgotten mysteries of the created world, and it definitely points towards a transcendent meaning, an ultimate goal. This paper examines how the specific relationship between self and nature can be associated with the peculiar worldview and the transcendental experiences of Weöres’s poetry.
Article history: Received 15 March 2022; Revised 9 May 2022; Accepted 22 May 2022; Available online 30 June 2022; Available print 30 June 2022.
REZUMAT. Relațiile dintre natură-transcendență și eu-natură în lirica lui Sándor Weöres. În poeziile lui Sándor Weöres flora și fauna nu sunt doar un fel de decor, un fundal alegoric/metaforic care servește la reprezentarea alienării eului, la experiența unui univers haotic al secolului XX, ci mai degrabă realitatea entităților independente de conștiința subiectivă, o realitate care poartă în ea însăși secretele uitate ale Creației și care indică, în mod evident, spre un scop final, un sens transcendent. Lucrarea de față, examinează modul în care relația dintre eu și natură poate fi legată de viziunea specifică asupra lumii și experiențele transcendentale ale acestei lirici.
Cuvinte-cheie: poezie maghiară, literatura secolului 20, timp și eternitate, natură, credință
Encuestas nacionales de juventud en América Latina y el Caribe
Authors: Pereyra Eduardo , Cozachcow Alejandro , Colombari Bruno
Published: June 2022

Los autores analizan las formas en que los Estados de América Latina y el Caribe producen información sobre la población juvenil, mediante una sistematización de las encuestas nacionales sobre juventudes realizadas en dieciocho países entre 1987 y 2019, y de entrevistas a responsables de estas encuestas en cuatro países que las aplican con regularidad. Esto permite conocer los factores que inciden en la sistematicidad, los usos y las valoraciones que han tenido los datos producidos, y en la relevancia que estos instrumentos adquieren en el continente.
NILAI KEMANUSIAAN DAN FUNGSI SOSIAL: PENYELENGGARAAN RUMAH SAKIT BERBENTUK PERSEROAN TERBATAS
Authors: Patty Henry Richard , Prananingrum Dyah Hapsari
Published: June 2022

Tulisan ini membahas rumah sakit berbentuk badan hukum Perseroan Terbatas yang diakui oleh Undang-Undang Nomor 44 Tahun 2009 tentang Rumah Sakit (UU Rumah Sakit), merupakan suatu pertentangan dengan nilai kemanusiaan dan fungsi sosial di dalam UU Rumah Sakit. Pasal 21 UU Rumah Sakit merumuskan bahwa rumah sakit privat sebagaimana dimaksud dalam Pasal 20 ayat (1) dikelola oleh badan hukum dengan tujuan profit yang berbentuk Perseroan Terbatas atau Persero. Hal ini berbeda dengan pengaturan Pasal 2 UU Rumah Sakit yang menyatakan bahwa rumah sakit diselenggarakan berasaskan Pancasila dan didasarkan kepada nilai kemanusiaan, etika dan profesionalitas, manfaat, keadilan, persamaan hak dan anti diskriminasi, pemerataan, perlindungan dan keselamatan pasien, serta mempunyai fungsi sosial. Penulis berpendapat bahwa terdapat perbedaan nilai dalam UU Rumah Sakit yaitu di satu sisi rumah sakit akan tunduk pada nilai kemanusiaan dan fungsi sosial sedangkan di sisi lain lebih kepada prinsip mencari keuntungan.
PEMIDANAAN DIBAWAH ANCAMAN PIDANA MINIMUM KHUSUS PADA PERKARA PERSETUBUHAN TERHADAP ANAK DALAM PERSPEKTIF HUKUM PROGRESIF (Studi Putusan Nomor 235/Pid.Sus/2018/PN.Mkd)
Authors: Pramudyani Dwi , Frans Mardian Putra
Published: June 2022

Artikel ini akan membahas tentang putusan pengadilan yang menjatuhkan pidana dibawah minimum khusus pada tindak pidana persetubuhan terhadap anak yang diputus oleh Pengadilan Negeri Magelang di Mungkid dengan Nomor 235/Pid.Sus/2018/PN.Mkd. Anak mempunyai peran penting dalam perkembangan pembangunan bangsa dan negara sehingga negara bertanggungjawab memberikan perlindungan terhadap anak. Permasalahan pada putusan ini adalah hakim dinilai tidak melaksanakan perlindungan bagi anak sebagaimana tujuan pembatasan ancaman pidana minimum khusus yang telah ditentukan di dalam UU Nomor 17 Tahun 2016 tentang Perlindungan Anak.
Alltagskommunikation in der digitalen Gesellschaft: Vorschlag eines Konzepts zur Analyse zwischenmenschlicher Kommunikation
Authors: Wagner Anna
Published: June 2022

Im Beitrag wird das Konzept der Alltagskommunikation vorgeschlagen, welches darauf abzielt, die komplexe zwischenmenschliche Kommunikation in der digitalen Gesellschaft kontextualisiert zu analysieren. Das Konzept verortet die von unterschiedlichen Medien geprägten, mobilen und mitunter parallel verlaufenden Kommunikationsprozesse mit anderen Menschen in der Alltagswelt eines Individuums. Es begreift diese Prozesse als miteinander in Beziehung stehend, in überdauernde Strukturen der zwischenmenschlichen Kommunikation eingebettet und durch diese beeinflusst. Das Analysekonzept lässt sich empirisch anwenden, indem spezifische (thematische) Ausschnitte der zwischenmenschlichen Kommunikation fokussiert und ganzheitlich unter Rückgriff auf vier Analyselinsen analysiert werden. Diese Analyselinsen umfassen 1) die kommunikativen Beziehungen, innerhalb derer die zwischenmenschliche Kommunikation stattfindet, 2) die Kommunikationsmuster, durch die die Kommunikation geprägt ist, 3) die Medien- und Kommunikationsrepertoires, auf die zur Kommunikation zurückgegriffen wird sowie 4) die Funktionen, welche die Kommunikation erfüllt. Im Artikel wird das Konzept der Alltagskommunikation zunächst expliziert, bevor dessen empirische Umsetzbarkeit anhand einer Fallstudie zur Kommunikation über satirische Medieninhalte illustriert wird.
In this contribution, the concept of Alltagskommunikation (everyday communication) is introduced, which aims to analyze the complex interpersonal communication entanglements in the digital society in a contextualized way. The concept locates the mobile and sometimes parallel communication processes with other individuals, which are shaped by different media, within the lifeworld of an individual. These processes are understood as interrelated, embedded in and influenced by permanent structures of interpersonal communication. To empirically apply the concept, specific (thematic) segments of interpersonal communication are examined and analyzed holistically through four analytical lenses. These analytical lenses comprise 1) the communicative relationships, in which the interpersonal communication takes place, 2) the patterns of communication by which communication is shaped, 3) the media and communication repertoires utilized for communication, and 4) the functions the communication fulfills. In this article, first, the concept of everyday communication is explicated and, second, its empirical feasibility is illustrated in a case study on interpersonal communication about satirical media content.
The ordinary negative changing refractive index for estimation of optical confinement factor
Authors: Abdullah Ahmad S. , Hbeeb Sadeq Adnan
Published: June 2022

The electro-optic effect is considered very important in optical communication systems. The small optical confinement factor is attributed to the weak overlap between the electric field and optical wave and hence the optical signal is not efficiently modulated. In this paper, the problem of the small optical confinement factor in the Mach–Zehnder modulator based on lithium niobate (LN) which is deeply studied. The data were analyzed through a proposed mathematical model to explain the relationship between the change in the ordinary negative refractive index and the confinement factor. The system is improved using a small length of the modulator arm as only 3 to 8 µm, low driving power of about 4 V/µm, a large change in the negative ordinary refractive index of about—0.2 × 10−7, and a compact optical modulator. This can reflect a strong optical confinement factor when the electric field is applied to the electrodes of the optical modulator.
Escovagem dentária e outras atividades de promoção da saúde oral em educação pré-escolar
Authors:   Unidade de Investigação em Ciências Orais e Biomédicas (UICOB), Faculdade de Medicina Dentária, Universidade de Lisboa, Lisboa, Portugal, Silva Alícia , Mendes Sónia ,   Unidade de Investigação em Ciências Orais e Biomédicas (UICOB), Faculdade de Medicina Dentária, Universidade de Lisboa, Lisboa, Portugal, Bernardo Mário ,   Unidade de Investigação em Ciências Orais e Biomédicas (UICOB), Faculdade de Medicina Dentária, Universidade de Lisboa, Lisboa, Portugal
Published: June 2022

Objetivos: Os objetivos deste estudo foram caracterizar a implementação da escovagem e de outras medidas de promoção da saúde oral em jardins de infância e identificar os fatores que influenciam a implementação da escovagem dos dentes. Métodos: A recolha de dados foi efetuada através de um questionário online dirigido aos educadores de infância a lecionar em Portugal. O questionário incluiu a caracterização do jardim de infância, do educador, da escovagem dos dentes e de outras medidas. Foi realizada a estatística descritiva e inferencial, utilizando o teste não-paramétrico do qui-quadrado (α=0,05). Resultados: A amostra incluiu 1618 educadores de infância, com uma média de 47,1 anos (dp=9,975). A escovagem diária era realizada em 40,6% dos jardins de infância. As principais razões apontadas para a não escovagem foram o risco de transmissão de doenças e limitações de recursos humanos e de espaço. Uma percentagem considerável de jardins de infância (43,8%) nunca foi visitada pelas equipas de saúde oral. Nos jardins de infância onde os educadores exercem há mais anos (p=0,004), onde os educadores tiveram formação sobre saúde oral (p<0,001) e onde as equipas de saúde oral atuaram (p<0,001), a escovagem dos dentes foi mais frequente. Conclusões: A escovagem dos dentes revelou-se implementada em menos de metade dos jardins de infância portugueses, sendo que esta é potenciada pela formação dos educadores em temas sobre saúde oral e pelas ações das equipas de saúde oral,
Bio profiling of Antibacterial activity of Punica granatum L.: An Ethnonutraceutical Against Cariogenic Streptoccoci
Authors: PANDEY MINAKSHI , Senthil Kumar R.
Published: June 2022

Recently, usage of medicinal plant extracts and herbs as an alternative natural control agent for commercially existing chemical synthesized drugs in cure of oral infectious diseases like periodontal disease and dental caries has been popularized immensely. The present study was aimed to assess the efficacy of antibacterial potency of Punica granatum peel extracts on five common but major oral pathogenic bacteria such as Streptococcus mutans, Streptococcus sanguinis, Streptococcus salivarius, Streptococcus sobrinus and Streptococcus mitis on carcinogenesis. The anti-microbial activity was investigated using Disc infusion technique by assessing Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The extracts were prepared using water, ethanol and chloroform in different concentration by serial dilution (dilution by one-half) using sterile distilled water solvent. The crude extracts were evaluated on Brain Heart Infusion agar along with Ampicillin as positive control and water as negative control. Results obtained showed that the crude ethanolic, aqueous, chloroform extracts of Punica granatum L. demonstrated broad spectrum of inhibition by showing antibacterial effect against Oral streptococci bacteria. The extracts were found less effective on S. salivarius and more effective on S. sanguis, where ethanol extract showed highest effectiveness even in comparison with Ampicillin. The results exhibited in present research study leads to the scientific evidence for the primeval usage of this plant as a medicinal ethno-nutraceutical and considered to be potent and effectual alternative compared to synthetic medicines.
Anti-diabetic Potential of Extract Obtained from Parkia biglandulosa (mimosaceae) Stems Bark using Alloxan Induced Diabetes Model
Authors: Kolhe Rohini C. , Chaudhari Rajesh Y. , Patil Vijay R.
Published: June 2022

Diabetes mellitus is a chronic metabolic disorder that places a huge health and economic burden on societies. Since currently available medications have many drawbacks, it is important to seek alternative therapies. Medicinal plants used in traditional medicine are ideal candidates. Therefore, this study was carried out to investigate the anti-diabetic activity of the stem bark extract of Parkia biglandulosa (mimosaceae) in wister rats. The phytochemical composition of the stem bark extract was qualitatively evaluated using standard procedures. In vivo anti-diabetic activity was performed by using the alloxan-induced diabetes method by orally administering methanolic extract of stem bark at doses of 200 and 400 mg/kg of body weight and profiling blood glucose levels at 0, 7, 14, 21 days using a glucometer. Biochemical parameters such as cholesterol, high-density lipoproteins, low-density lipoproteins, creatinine, urea and alkaline phosphatase were also evaluated. P. biglandulosa stem bark extract at the tested dose levels of 200 and 400 mg/kg showed a significant reduction in blood glucose level with 175.34 ± 9.357 and 171.69 ± 6.248 mg/dL respectively as compared with diabetic control grouP. The observed anti-diabetic activity could be associated with the phytochemicals present in this plant extract. The results suggest that P. biglandulosa bark extract possess anti-diabetic activity and this validates its folkloric use.
Design Development and Characterisation of Mupirocin Loaded Emulsion Based Gel
Authors: Lakkad Hardik A. , Patel Vipul P.
Published: June 2022

The objective of the present study was to develop more retentive and effective drug delivery system for mupirocin. The research was going on in achieving effective formulation. Mupirocin is an anti-microbial agent that is used in wounds healing treatment. First Screening of oil, surfactant and co-surfactant for SEDDS carried out. Solubility of drug was investigated in different oils, surfactant and co-surfactants by UV method. A drug was dissolved in available oil in which it exhibited maximum solubility, then surfactant and co-surfactant were added in which drug showed maximum solubility, mixed well on a magnetic stirrer. Transparent SEDDS were formed. Carbopol 940 and Polyacrylate sodium gelling agent was suspended in water and hydrated for overnight separately. For preparation of Emulgel, various ratios of gel and SEDDS were set. Emulgel was evaluated for %drug release, pH, and drug content. The results indicated that Emulgel gave better controlled release. The formulation F11 showed 99.27 percent drug release, pH 6.7 ± 0.1 and drug content 99.4 ± 0.11%. Formulation F11 was selected as an optimized formulation. The formulations of Emulgel delivered very good therapeutic efficacy for topical application.
Identification of Potential anti-dengue lead from Nilavembu through in silico study
Authors: Lekshmi Radha K. N. , Biju Charuvil K. , Sreekumar Sivanandan
Published: June 2022

Dengue fever is a severe mosquito-borne global health concern caused by the Dengue virus. There are no effective vaccines or anti-virals against dengue, even though several medications are under developmental stages. As we all know, the traditional medicine system mainly depends on plants to treat various types of diseases caused by bacteria, viruses, and other micro-organisms. In this scenario, the present study focussed on identifying the inhibitory potential of phytoconstituents from a well-known antipyretic medicinal herb Andrographis paniculata (Burm.f.) Nees against MTase domain of NS5 protein from the virus and IMPDH2 from the host through Molecular docking to identify the hit compounds and further drug-likeness, pharmacokinetics, and toxicity studies were carried out to ascertain a lead candidate. Through molecular interaction results, it was identified that in the case of NS5, about 28 compounds showed the least binding energy than native ligand SAH and were recommended as hits, out of which 12 compounds interact specifically with the active site residues and were selected as top hits. In the case of IMPDH2, 13 compounds were identified as hits since they showed less binding energy than native ligand RVP, and among that, nine compounds were selected as top hits based on their interaction with the active site residues. Furthermore, the selected hit molecules were subjected to drug-likeness, pharmacokinetics, and toxicity prediction and identified Oleanolic acid as the best lead candidate against both the targets NS5 and IMPDH-II. The study further emphasizes Oleanolic acid as the best lead candidate because naturally, triterpenoid compounds possess anti-viral activity but further in vitro and in vivo studies are essential to propose Oleanolic acid as an anti-dengue compound.
DEVELOPMENT OF CANDESARTAN LOADED SOLID LIPID NANOPARTICLES BY BOX-BEHNKEN DESIGN
Authors: Ramulu Yelugudhari , Bhikshapathi Darna
Published: June 2022

The primary motive behind this the present investigation was to develop and optimize the solid lipid nanoparticles formulation of candesartan to enhance solubility and dissolution rate. The prepared SLNs, composed of precirol, poloxamer 188, soy lecithin, tween 80, were fabricated employing hot emulsification/ ultrasonication technique. Box-Behnken design was employed for 17 formulation batches in which 3 factors namely lipid, surfactant, and co-surfactant (precirol, poloxamer 188 and soy lecithin) tween 80 were tested at 3 levels of their concentration, i.e., low, medium and high. The effect of different levels of factors was evaluated for the particle size, entrapment efficiency and % cumulative drug release. Kinetic model fitting for candesartan solid lipid nanoparticles (SLN) formulation was done to interpret the release rate from the SLN. Optimized formulation was subjected for fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and stability studies. The mean particle size, PDI, zeta potential, entrapment efficiency, content uniformity and in-vitro drug release of optimized candesartan-loaded SLNs (CD10) were found to be 135.38 ± 3.41 nm, 0.125 ± 0.04, -18.16 ± 2.89 mV, 86.4 ± 2.35%, 99.78 ± 2.54% and 98.91 ± 0.85% respectively. The release kinetics suggested that drug release followed zero-order and release was anomalous non-fickian diffusion super case II transport. FTIR studies revealed no incompatibility between drug and excipients, SEM images exhibited nanoparticles to be more porous and in a spherical shape. Stability studies indicated good stability of the formulation. The proposed way of SLN preparation could be considered a proper method for producing a candesartan-loaded colloidal carrier system.