bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Distress Levels in Pregnant Women: A Descriptive and Cross-Sectional Study
Authors: AKBAŞ Meltem , ÇELİKKANAT Şirin , GÖKYILDIZ SÜRÜCÜ Şule
Published: May 2020

Objectives: The purpose of the study is to identify distress levels and the affecting factors in pregnant women. Methods: This study was conducted in the Non-Stress Test unit of a Maternity and Children Hospital between 1st and 31st of March, 2017 in Turkey. This study is descriptive and cross-sectional. The participants were 250 pregnant women who met the research criteria and volunteered to participate in the study. Data were collected using the “Socio-demographic Form” and “Tilburg Pregnancy Distress Scale”. Analysis of the data was performed using percentages, means, student t-test, ANOVA, and Linear Regression. Results: The average age of pregnant women was 26.73. Of all the participants, 52.2% graduated from primary school, 93.5% did not work, 79.6% had social security, partners of 43.3% were workers, 74.7% had medium financial level, 79.6% had a nuclear family, 66.1% experienced their first pregnancy, 90,6% had planned their pregnancy, and 64.9% had a living child. The mean score for the total scale was 23.54±7.590; mean score for the negative effect sub-scale was 20.81±6.560, and mean score for the partner involvement sub-scale was 2.73±2.967. According to the cut-off point, 25.3% of pregnant women were found to be distressed. Conclusions: This study found that approximately one-fourth of the pregnant women were distressed, which was considered to result from their socio-demographic and obstetric features. A holistic approach should be applied to pregnant women in their pregnancy follow-ups considering their psychological needs as well as physiological and biological ones.
Estimación de biomasa aérea y carbono, en rodales con y sin manejo forestal en la Reserva de la Biosfera Mariposa Monarca
Authors: Hernández-Moreno José Antonio , Velázquez-Martínez Alejandro , Fierros-González Aurelio Manuel , Gómez-Guerrero Armando , Reyes Hernández Valentín José , Vera-Castillo José Amando Gil
Published: May 2020

La estimación de biomasa aérea acumulada en un bosque con manejo para el aprovechamiento forestal maderable es de importancia para evaluar la sustentabilidad por efecto del sistema silvícola, y para entender la dinámica y funcionamiento de los ecosistemas forestales. La acumulación de biomasa aérea refleja la productividad en un sitio determinado. En este trabajo se estimó la biomasa aérea y el carbono, en rodales con y sin manejo forestal, en el Ejido Chincua, Senguio, Michoacán, a través de la generación de ecuaciones alométricas para Abies religiosa (Kunth) Schltdl. & Cham y Pinus pseudostrobus Lindl, mientras que para las latifoliadas se usaron ecuaciones de otros estudios y, además, mediante datos de inventario para todas las especies. El rodal sin manejo tuvo una biomasa de 323.23 Mg ha-1, mientras que el rodal con manejo 287.62 Mg ha-1, los cuales, a pesar de su variabilidad no presentan diferencias significativas (P = 0.96). El contenido de carbono tampoco presentó diferencias significativas (P = 0.97), siendo 155.03 Mg ha-1 y 128.44 Mg ha-1 en los rodales sin y con manejo, respectivamente. Los resultados indican que con el manejo forestal, bajo el sistema silvícola de selección, se conservaron la estructura y composición del rodal con manejo, lo que permitió mantener el almacén de biomasa en una cantidad similar a la de un bosque sin manejo; por lo anterior, los bosques manejados pueden ser sumideros eficientes de carbono, más la cantidad de este elemento en el proceso de cosecha y transformación de la madera a productos forestales de larga duración, como son madera para construcción, muebles, durmientes, postes, entre otros, que permiten su permanencia por periodos relativamente largos.
How Far Can Telehealth Help Patients in Social Distancing due to Covid-19 in Low- and Mid-Income Countries? (Preprint)
Authors: Fernandes Livia , Saragiotto Bruno
Published: May 2020

UNSTRUCTURED

Social distancing and movement restriction, most recommended protective measures to slow the spread of the SARS-CoV-2 virus (responsible for COVID-19 outbreak), encourage the uptake of telehealth initiatives. Telehealth allows for treatment continuation in situations face-to-face encounters are potentially unsafe. Nevertheless, inadequate health literacy and digital health literacy are barriers to the use of telehealth in low- and mid- income countries. The context of Brazil and how the country has been managing pandemic response was used to discuss alternatives towards a democratic telehealth implementation.
Effect of Nano-Silica on The Thermo-Physical Properties of the Thermal Eutectic (Na0.6K0.4)NO3 System
Authors: ElSaeedy H. I. , Al Ahmari A. A. S. , Abd El-Rahman K. F. , Taha S.
Published: May 2020

Here, we investigate the effect of adding nano-silica particles on the thermo-physical properties of the (Na0.6K0.4)NO3 based thermal energy storage systems. Five different systems tagged as M00, M01, M02, M03 and M04, with different nano-silica percentage of 0, 1, 2, 3, and 4 wt%, respectively, were prepared. Various experimental techniques were employed to study the thermo-physical properties of the systems during (solid-solid) phase P1, (solid-liquid) phase P2 and (liquid-solid) phase P3, and to clarify the effect of nano-silica on the thermal energy storage efficiency during both charging and discharging processes. According to the Differential Scanning Calorimeter (DSC) thermal analysis, it was found that the system M02 whose nano-silica addition rate of 2 wt%, has the most favorable thermal characteristics (i.e., highest specific heat and lowest enthalpy change). Moreover, the addition of 2 wt% represents the optimum distribution of nano-silica inside the principal base system M00. This leads to an improvement in the porosity of the system due to the degree of homogeneity caused by the thermophoresis effect distribution, the high surface area of the nano-silica with the activity of the M00 matrix alongside the degree of the alkalinity of nano-silica. Besides, the electric conductivity measurements showed that the 2wt% percentage is the optimum one for thermal energy storage systems.
Efecto de los gusanos de terciopelo (Onychophora) en la cultura y arte durante el periodo 2014-2019; representaciones, temáticas y distribución mundial.
Authors: Arias-Paco Andrés
Published: May 2020

Introducción: Los gusanos de terciopelo son un grupo de invertebrados actualmente terrestres, que se consideran fósiles vivientes, con más de 520 millones de años de existir. Su forma de caza consiste en el disparo de una goma pegajosa que envuelve a sus víctimas, y algunas especies tienen placenta. Al ser animales con características tan peculiares, pero que tradicionalmente no entran en la categoría de “especies carismáticas”, es interesante la influencia cultural y artística que actualmente puedan tener. Objetivo: Esta investigación tiene como objetivo ver cómo ha influenciado Onychophora la cultura y arte en los años posteriores al estudio de Monge-Nájera & Morera-Brenes (2015). Métodos: Busqué las producciones culturales y artísticas relacionadas a Onychophora en la web, mediante los nombres más comunes que reciben estos animales en diferentes países, para observar si la cantidad de producciones ha aumentado. Además, clasifiqué las producciones en temas y de acuerdo al tipo de impresión (positiva o negativa). Resultados: Encontré 336 producciones culturales y artísticas relacionadas a Onychophora, de las cuales la mayoría corresponden a dibujos animados, luego a productos sublimados, artesanías, imágenes editadas y videos. También encontré 6 temas sobresalientes, y en la mayoría de casos, las producciones transmiten una imagen positiva. Los países con mayor producción en total son Estados Unidos, Australia y Nueva Zelanda, mientras que per cápita (por millón de habitantes) son Nueva Zelanda, Costa Rica y Australia. Conclusión: La morfología externa de los onicóforos principalmente, junto con su método de caza, ha generado un interés inesperado en la cultura y arte.
Effect of surgery-first orthognathic approach on oral health-related quality of life:
Authors: Yao Ke , Zhu Guanyin , Chen Miao , Zhang Bo , Wu Yongzhi , Li Peilin
Published: May 2020

Objectives

To systematically evaluate the effect of the surgery-first approach (SFA) on oral health-related quality of life (OHRQoL) in patients with dentofacial deformities.

Materials and Methods

An electronic database search and hand search of selected journals and references were carried out. Studies investigating the OHRQoL of patients receiving SFA with or without a control group were included. The risk of bias was assessed by the Cochrane risk of bias tool in randomized clinical trials (RCTs) and the Newcastle-Ottawa Scale in non-RCTs.

Results

A total of seven articles met the eligible criteria and were included, of which six were cohort studies and one was an RCT, and six assessed the OHRQoL of the SFA with conventional orthodontic–surgical treatment (COST) as a control and one without. A total of 214 patients were examined, with sample sizes in studies ranging from 9 to 50. A total of 3 articles successfully measured the OHRQoL both before and after treatment in both the SFA and conventional orthodontic–surgical treatment groups. A total of six cohort studies were classified as low to moderate risk of bias, and the RCT was classified as high.

Conclusions

The SFA could improve the OHRQoL of patients with dentofacial deformities similar to conventional orthodontic–surgical treatment at the end of complete treatment. In addition, it increases OHRQoL immediately at the beginning of treatment without a deterioration.
Microbiota intestinal: impacto en la enfermedad metabólica
Authors: Delgado Cruz Mayra Daniela , Yugcha Carpio Abigail Gissela , Cedeño Veintimilla María Soledad , De los Ríos Tomalá Pedro Gerargo , Molina Peñaherrera Jenniffer Katherine
Published: May 2020

La microbiota del intestino cumple una serie de funciones metabólicas e inmunológicas en el ser humano, lo que permite buen estado de salud. Se conoce actualmente las implicaciones que tiene la alteración de la microbiota intestinal y la respuesta adversa del hospedero a estos cambios (disbiosis) sobre las enfermedades metabólicas. El sobrepeso y la obesidad constituyen factores de riesgo para un gran número de enfermedades crónicas, como el síndrome metabólico, la diabetes, las enfermedades cardiovasculares y algunos tipos de cáncer. Es así como el desequilibrio en la composición de la microbiota intestinal se han asociado a una mayor susceptibilidad a las infecciones y los trastornos de base inmunológica y, recientemente, también a la resistencia a la insulina y al aumento del peso corporal. En relación a la evidencia actual, resulta importante investigar los efectos en la modificación de la microbiota intestinal, mediante el uso alimentos funcionales probióticos y prebióticos, a fin de intervenir y prevenir el desarrollo de la obesidad y las alteraciones metabólicas.
İlköğretim Matematik Öğretmen Adaylarının Matematiksel İspata Yönelik Görüşlerinin Belirlenmesi: Kars Örneklemi
Authors: ALTINTAŞ Esra , İLGÜN Şükrü
Published: May 2020

Mevcut araştırma kapsamında ilköğretim matematik öğretmenliği 1-2-3 ve 4. sınıflarında eğitim görmekte olan öğretmen adaylarının ispata yönelik görüşlerinin ortaya konması amaçlanmıştır. Mevcut araştırma İlköğretim Matematik Öğretmenliği Anabilim Dalı öğrencilerinin eğitimlerinin ispata yönelik görüşlerine bir katkısı olup olmadığı hakkında yorum yapabilme ve ispat yönteminin öğrencilerin gözünden yansımalarının ortaya konması bakımından önem taşımaktadır. Mevcut araştırma kapsamında tarama modeli kullanılmıştır. Araştırmanın örneklemini 143 öğretmen adayı oluşturmaktadır. İlköğretim matematik öğretmenliği öğrencilerine Matematiksel İspata Yönelik Görüş Ölçeği (MİYGÖ) uygulanmış olup, 1., 2., 3. ve 4. sınıf öğrencilerinin matematiksel ispat yöntemleriyle ilgili görüşler ölçeği puanları arasında fark olmadığı ve öğretmen adaylarının ispata yönelik görüşlerinin ortalamalarının boyutlar çerçevesinde “kararsızım” aralığında olduğu sonucuna ulaşılmıştır.
Aortocoronary conduits may show a different inflammatory response - comparative study at transcript level
Authors: Nawrocki Mariusz J. , Kałużna Sandra , Jopek Karol , Hutchings Greg , Perek Bartłomiej , Jemielity Marek , Malińska Agnieszka , Kempisty Bartosz , Mozdziak Paul , Nowicki Michał
Published: May 2020

Coronary artery bypass grafting (CABG), together with percutaneous coronary intervention (PCI), are both still the most efficient procedures for myocardial revascularization to treat advanced coronary artery disease (CAD). Donor blood vessels used in CABG are usually the internal thoracic artery (ITA) and saphenous vein (SV). The importance of inflammation and inflammatory pathways in graft patency is well established. Nevertheless, not all molecular mechanisms underlying the inflammatory process appear to be clear. Employing the expressive microarray approach to analyze the transcriptome of both venous and arterial grafts, five GO BP terms has been selected: “cellular response to interferon-gamma”, “inflammatory response”, “interferon-gamma-mediated signaling pathway”, “response to interferon-gamma” and “positive regulation of inflammatory response”. This study aimed to evaluate potential molecular factors that could be characteristic markers for both SV and ITA conduits.

Running title: Aortocoronary conduits may show a different inflammatory response
New molecular markers involved in immune system homeostasis and hemopoietic organ development are differentially regulated during oocytes in vitro maturation
Authors: Moncrieff Lisa , Kocherova Ievgeniia , Bryja Artur , Kranc Wiesława , Perek Joanna , Celichowski Piotr , Kulus Magdalena , Kempisty Bartosz , Mozdziak Paul , Jeseta Michal
Published: May 2020

The growth and maturation of the oocyte is a dynamic process which requires a variable supply of hormones, growth factors and energy. These needs are met partially by the surrounding somatic cells and the cumulus-oocyte complex, which communicate bi-directionally via gap junctions. Identifying and analyzing protein expression in the oocyte can provide insight in its development and growth. Further, like bone marrow stem cells, if relevant marker genes are found in oocytes, there is a potential for the oocyte to be manipulated into becoming hemopoietic stem cells. In this study, porcine oocytes were isolated and subjected to microarray analysis to compare the oocyte gene expression in vivo and in vitro maturation (IVM). Genes identified belonged to both ‘hemopoietic or lymphoid organ development’(GO:0048534) and ‘immune system development’ (GO:0002520), and the markers can be used to identify several activities such as cell migration, neurogenesis and proliferation. The following are the identified genes and all were downregulated after IVM to varying degrees: ID2, VEGFA, TGFBR3, INHBA, CDK6, BCL11A, MYO1E, ITGB1, EGR1, NOTCH2, SPTA1, KIT and TPD52. Our results should provide new markers to further investigate oocyte development and growth regulation.

Running title: Markers of hemopoietic organ development
Cell-based approaches in drug development – a concise review
Authors: Kocherova Ievgeniia , Kempisty Bartosz , Hutchings Greg , Moncrieff Lisa , Dompe Claudia , Janowicz Krzysztof , Petitte Jim , Shibli Jamil A. , Mozdziak Paul
Published: May 2020

In vitro models represent an alternative technique to in vivo or ex vivo studies in the drug development process. Cell-based assays are used to measure the level of proliferation and toxicity, as well as activation of signalling pathways and changes in morphology in cultivated cells. The studies conducted in vitro are aimed to estimate the newly synthesised drugs’ ability to permeate biological barriers and exert their therapeutic or cytotoxic effects. However, more than half of all studied drugs fail in the second or third phase of clinical trials due to a lack of confirmed efficacy. About a third of drugs fail because of safety issues, such as unacceptable levels of toxicity. To reduce attrition level in drug development, it is crucial to consider the implementation of translational phenotypic assays as well as to decipher various molecular mechanisms of action for new molecular entities. In this review, we summarise the existing cell-based methods most frequently used in the studies on drugs, taking into account their advantages and drawbacks.

Running title: Cell-based approaches in drug development
Bronchial Asthma: Current Trends in Treatment
Authors: Palova R , Adamcakova J , Mokra D , Mokry J
Published: May 2020

Asthma is a heterogenous disease which pathophysiology is still poorly understood. Asthma was traditionally divided into allergic (extrinsic) and non-allergic (intrinsic) types, while patients with allergic type responded better to corticosteroids. Since 2013 the definition of asthma has changed. Recently, better insight into clinical consi -derations and underlying inflammatory phenotypes has been gained. Defining these phenotypes has already led to more specific clinical trials and, therefore, to more personalized and successfully targeted therapy. For future, much more effort is put in identifying new phenotype-specific biomarkers which could be helpful in stratification of heterogeneous patients with asthma.
Brachial Plexopathy as an Unusual First Sign of a Head and Neck Cancer: Case Report
Authors: Surova V , Slavik P , Calkovsky V , Hajtman A.
Published: May 2020

Malignancies in the ENT (Ear, Nose, and Throat) area are mostly manifested by dysphagia, dysphonia, dyspnea, throat swelling, and other “traditional” head and neck symptoms. Sporadically, a primary tumor or metastasis can reach such a size and it can be localized in such an area in which it can cause the pathology of the brachial plexus. If this appears first, differential diagnosis may be more difficult.

In this article the authors review current literature knowledge and present the case of this unusual sign of a head and neck cancer at the Clinic of Otorhinolaryngology and Head and Neck Surgery, Jessenius Faculty of Medicine, Comenius University, and Martin University Hospital, Martin, Slovakia.
HPLC method development for fampridine using Analytical Quality by Design approach
Authors: Kovács Béla , Boda Francisc , Fülöp Ibolya , Székely-Szentmiklósi István , Kelemen Éva Katalin , Kovács-Deák Boglárka , Székely-Szentmiklósi Blanka
Published: May 2020

Offering a systematic and multivariate analysis of the analytical procedure, development and validation of HPLC methods using Quality by Design approach are in the limelight of current research trends. A new, experimental design-aided HPLC method for fampridine was developed and preliminarily validated according to current in-force international guidelines for linearity, accuracy, robustness and precision.

The method offers a high throughput sample analysis, with an elution time of 2.9 minutes, and signal detection without excipient interference performed at 262 nm. The method proved to be linear between 1–15 µg mL−1 (R2
= 0.9996). The mean recovery was found to be 98.7 ± 1.9 % in the tested range of 2.5–7.5 µg mL−1. Low RSD values (< 1 %) were obtained for both model, intra- and inter-day precision. The limit of detection and limit of quantification were 0.24 and 0.78 µg mL−1, resp. The method proved to be applicable for active substance assay in a pharmaceutical dosage form.
Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads
Authors: Vlachou Marilena , Siamidi Angeliki , Goula Efstratia , Georgas Panagiotis , Pippa Natassa , Karalis Vangelis , Sentoukas Theodore , Pispas Stergios
Published: May 2020

A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance.
Phylogenetic Analysis of HA and NA Genes of Swine Influenza Viruses in Serbia in 2016-2018
Authors: Maksimović Zorić Jelena , Milićević Vesna , Stevančević Ognjen , Chiapponi Chiara , Potkonjak Aleksandar , Stojanac Nenad , Kureljušić Branislav , Veljović Ljubiša , Radosavljević Vladimir , Savić Božidar
Published: May 2020

Pigs are very important for the epidemiology of influenza A viruses, being commonly infected with the lineages of most adapted H1N1, H3N2, H1N2 swine subtypes. Epidemiological complexity of swine influenza is increasing by a periodic spillover of human or avian viruses in the pig population when genetic shifts can occur. The objectives of this research were to determine the presence of the influenza A virus in nasal and tracheobronchial swabs and lung tissue samples of ill and dead pigs on commercial farms, to determine circulating subtypes and characterize them through the phylogenetic analysis of hemagglutinin (HA) and neuraminidase (NA) genes. A total of 255 samples collected from 13 farms were analyzed by means of real-time RTPCR. The genome of influenza A virus was detected in 24 samples, which represented a 61.5% prevalence at the farms level (influenza A virus was confirmed in 8 out of 13 farms included in this study). Based on HA and NA gene sequences of 8 viruses, the circulation of H1N1 and H3N2 subtypes of influenza A viruses were determined. In addition, one farm exhibited a time separated circulation of H1N1 and H3N2 virus subtypes. Using Influenza Research Database, our viruses of the H1 subtype were classified into 1C.2.1 and 1A.3.3.2. clade. Based on the nucleotide sequences of HA genes, three viruses of the H1N1 subtype belong to the H1N1pdm09 lineage, and the other four to Eurasian “avian-like” H1avN1 lineage; while based on NA genes sequences, these seven viruses belong to Eurasian “avian-like” H1avN1 lineage. Both HA and NA genes of the virus of the H3N2 subtype belonged to the A/swine/ Gent/1/1984-like H3N2 lineage.
Dietary Supplementation of a Yeast-Whey Preparation for Weaned Piglets
Authors: Szuba-Trznadel Anna , Hikawczuk Tomasz , Korzeniowska Małgorzata , Fuchs Bogusław
Published: May 2020

Weaning is a stressful period for the piglets and the sow. Stress during weaning is related to the change of diet which can affect the physiology of the gastrointestinal tract, as well as the microbial and immunological status of the animals. In the experiment a yeast-whey preparation was used to decrease the transient growth depression related to reduction of feed intake by the piglets. The piglets were assigned to three treatments. In the control group (I) the animals obtained standard feed mixture used routinely at the farm. In the case of piglets from II and III treatment, the yeast-whey preparation was added in the quantity of 4 and 7%, respectively.

Application of 7% yeast-whey preparation to the diet significantly increased the body weight of piglets (p<0.05) and in consequence the average daily body weight gain (p<0.01) in comparison with the control group of animals. Additionally, piglets which were fed the yeast-whey preparation diet had a higher feed intake (p<0.05) and better feed conversion ratio (p<0.05) than those fed a diet without the addition of this preparation. No significant differences were stated for most biological parameters (p>0.05), except for the blood urea level, which was significantly lower (p<0.05) in the treatments where the yeast-whey preparation was used. These results indicated that yeast-whey preparation efficiently suppressed post-weaning diarrhea and improved the performance of the animals.
Research of 316L Metallic Powder for Use in SLM 3D Printing
Authors: Hajnys J. , Pagac M. , Mesicek J. , Petru J. , Spalek F.
Published: May 2020

3D metal printing is an increasingly popular production of steel parts. The most widespread and most accurate method is SLM (Selective Laser Melting), which uses metallic powder as the input material. The article is dedicated to researching the supplied powder from Renishaw. The powder is made by gas atomization and 3 phases of powder (virgin, sift and waste) that are present in the SLM process are examined. Powder morphology by SEM electron microscopy is investigated and the porosity of the powder is measured by optical method. Next, the powder grain size fraction is examined. In conclusion, there are recommendations and other directions of possible research. The main quantitative result from research is that, in general, small particles are reduced in the sift powder and the number of larger particles is increased, but the powder is still usable for further use.
Physiological Response to Non-Traditional High-Intensity Interval Training
Authors: Schlegel Petr , Hiblbauer Jan , Agricola Adrián
Published: May 2020

High intensity interval training (HIIT) is an exercise program not only for professional athletes, but also for the general population. Usually, one-dimensional modalities such as running or a cycling simulator are used. There also exist protocols that use the HIIT principles but apply full-body exercises (HWT). The purpose of the study was to verify the response to unconventional loads based on HIIT and HWT protocols using the near infrared spectroscopy (NIRS) and spiroergometry: wall ball (WB); SKI ergometer, toes to bar (TTB) and assault air bike (AB) in a selected proband. Working interval was 60 s resp. 30 s, the rest between sites was progressively reduced from 60 s to 30 s. The proband completed a total of 3 laps. The results showed that the load applied had been similar to that of HWT or HIIT, where the effect on cardiorespiratory and metabolic functions was confirmed. Acute changes in the observed parameters of SmO2 in m. vastus lateralis indicate a possible effect on the development of strength capabilities. It has also been confirmed that the application of variable types of load can be applied simultaneously with the adjustment of rest time and thus using conditions that can reflect current options (material, environment, time) and specific goals. The measured values of muscle tissue oxidation, carbon dioxide output, heart rate confirm that a similar type of load can be a suitable means of affecting cardiovascular and metabolic functions.
Factors Involved in the Pathogenesis of Acne and Its Psycho-Social Impact
Authors: Voidăzan Septimiu , Toth Reka , Varo Teodora
Published: May 2020

With acne as one of the most common and frequent conditions of young adult patients, we looked for significant associations, associated conditions with influence on the skin condition with the idea of outlining a different approach of the acne patient. With a multifactorial, multi-disciplinary etiopathogeny, the purpose of this study was to highlight the factors involved in the pathogenesis of this condition and to identify those that should be taken into account when prescribing the treatment.
Cardiac Autonomic Neuropathy in Diabetes Mellitus Patients – Are We Aware of the Consequences?
Authors: Motataianu Anca , Barcutean Laura Iulia , Maier Smaranda , Balasa Adrian , Stoian Adina
Published: May 2020

Cardiovascular autonomic neuropathy is the most frequent clinical form of autonomous diabetic neuropathy and appears secondary to cardiac autonomous fibre involvement, actively involved in cardiac rhythm impairment. Type 2 diabetes mellitus patients can present cardiac autonomic neuropathy early in the disease. Autonomous nerve function in DM patients should be assessed as early as the diagnosis is set in order to establish the optimal therapeutic strategy. The most frequent cardio-vagal test used is heart rate variability. An abnormal heart rate variability in the presence of orthostatic arterial hypotension indicates a severe cardiac autonomic neuropathy diagnosis. The development of cardiac autonomic neuropathy is subjected to glycaemic control, duration of the disease and associated risk factors. The glycaemic control is extremely important, especially early in the disease. Therefore, a poor glycaemic control carries unfavourable long-term effects, despite an ulterior optimal control, a phenomenon named “hyperglycaemic memory”. In type 2 diabetes mellitus patients, the association of cardiac autonomic neuropathy with intensive glycaemic control increases the mortality rate, due to the fact, that, secondary to autonomous impairment, the patients do not present the typical symptoms associated with hypoglycaemia. Stratifying the cardiac autonomic neuropathy aids the clinician in assessing the morbidity and mortality risk of diabetes mellitus patients, because it is an independent risk factor for mortality, associated with silent myocardial infarctions and the risk of sudden death.
The relative bioavailability of two formulations containing 10 mg Dapagliflozin assessed under fasting conditions in a randomized crossover study in healthy Caucasian subjects
Authors: Oroian Monica , Pop Diana Ioana , Gheldiu Ana-Maria , Bhardwaj Sandeep , Marcovici Adriana , Khuroo Arshad , Vlase Laurian
Published: May 2020

Objective: The aim of the present study was to evaluate the relative bioavailability of two formulations containing 10 mg dapagliflozin in healthy Caucasian subjects under fasting conditions.

Materials and Methods: Forty-eight healthy Caucasian subjects were enrolled in a single-dose, crossover, balanced, open label, randomized clinical trial, with two treatment, two periods and two sequences. The wash-out period was of 7 days and thirty-eight subjects completed both study periods. Each subject received a single dose of 10 mg dapagliflozin as the reference product Farxiga® (AstraZeneca Pharmaceuticals LP, USA) and the test product developed by Sun Pharmaceutical Industries, India. Dapagliflozin plasma levels were determined from blood samples collected in both study periods before and after dosing until 48 hours by using a validated LC-MS/MS method. For pharmacokinetic analysis of data, the non-compartmental method was used (Phoenix® WinNonlin 6.3). The statistical analysis was performed by SAS software 9.1.3 for the logarithmically transformed values of maximum plasma concentration and area under the curve.

Results: The 90% confidence intervals for the evaluated pharmacokinetic parameters were found to be in the accepted interval for bioequivalence (80.00-125.00%).

Conclusion: The 10 mg dapagliflozin immediate release tablet newly developed by Sun Pharmaceutical Industries, India, is bioequivalent with the reference product Farxiga® under fasted state of the subjects.
Fractional Calculus of the Extended Hypergeometric Function
Authors: Şahin Recep , Yağcı Oğuz
Published: May 2020

Here, our aim is to demonstrate some formulae of generalization of the extended hypergeometric function by applying fractional derivative operators. Furthermore, by applying certain integral transforms on the resulting formulas and develop a new futher generalized form of the fractional kinetic equation involving the generalized Gauss hypergeometric function. Also, we obtain generating functions for generalization of extended hypergeometric function..
Optimal position of piezoelectric actuators for active vibration reduction of beams
Authors: Kouider Bendine , Polat Alper
Published: May 2020

This paper investigates the optimal placement of piezoelectric actuators for the active vibration attenuation of beams. The governing equation of the beam is achieved by coupled first order shear deformation theory with two node element. The velocity feedback controller is designed and used to calculate the feedback gain and then apply to the beam. In order to search for the optimal placement of the piezoelectric actuators, a new optimization criterion is considered based on the use of genetic algorithm to reduce the displacement output of the beam. The proposed optimization technique has been tested for two boundary conditions configurations; clamped -free and clamped-clamped beam. Numerical examples have been provided to analyze the effectiveness of the proposed technic.
A Numerical Scheme For Semilinear Singularly Perturbed Reaction-Diffusion Problems
Authors: Yamac Kerem , Erdogan Fevzi
Published: May 2020

In this study we investigated the singularly perturbed boundary value problems for semilinear reaction-difussion equations. We have introduced a basic and computational approach scheme based on Numerov’s type on uniform mesh. We indicated that the method is uniformly convergence, according to the discrete maximum norm, independently of the parameter of ɛ. The proposed method was supported by numerical example.
A finite difference method on layer-adapted mesh for singularly perturbed delay differential equations
Authors: Erdogan Fevzi , Sakar Mehmet Giyas , Saldır Onur
Published: May 2020

The purpose of this paper is to present a uniform finite difference method for numerical solution of a initial value problem for semilinear second order singularly perturbed delay differential equation. A numerical method is constructed for this problem which involves appropriate piecewise-uniform Shishkin mesh on each time subinterval. The method is shown to uniformly convergent with respect to the perturbation parameter. A numerical experiment illustrate in practice the result of convergence proved theoretically.
New Analytical Solutions of Conformable Time Fractional Bad and Good Modified Boussinesq Equations
Authors: Durur Hülya , Tasbozan Orkun , Kurt Ali
Published: May 2020

The main purpose of this article is to obtain the new solutions of fractional bad and good modified Boussinesq equations with the aid of auxiliary equation method, which can be considered as a model of shallow water waves. By using the conformable wave transform and chain rule, nonlinear fractional partial differential equations are converted into nonlinear ordinary differential equations. This is an important impact because both Caputo definition and Riemann–Liouville definition do not satisfy the chain rule. By using conformable fractional derivatives, reliable solutions can be achieved for conformable fractional partial differential equations.
Evaluation of Investment Opportunities With Interval-Valued Fuzzy Topsis Method
Authors: Lanbaran Naiyer Mohammadi , Celik Ercan , Yiğider Muhammed
Published: May 2020

The purpose of this study is extended the TOPSIS method based on interval-valued fuzzy set in decision analysis. After the introduction of TOPSIS method by Hwang and Yoon in 1981, this method has been extensively used in decision-making, rankings also in optimal choice. Due to this fact that uncertainty in decision-making and linguistic variables has been caused to develop some new approaches based on fuzzy-logic theory. Indeed, it is difficult to achieve the numerical measures of the relative importance of attributes and the effects of alternatives on the attributes in some cases. In this paper to reduce the estimation error due to any uncertainty, a method has been developed based on interval-valued fuzzy set. In the suggested TOPSIS method, we use Shannon entropy for weighting the criteria and apply the Euclid distance to calculate the separation measures of each alternative from the positive and negative ideal solutions to determine the relative closeness coefficients. According to the values of the closeness coefficients, the alternatives can be ranked and the most desirable one(s) can be selected in the decision-making process.
Genome-Wide Association Study Using Fix-Length Haplotypes and Network Analysis Revealed New Candidate Genes for Nematode Resistance and Body Weight in Blackface Lambs
Authors: Farahani Amir Hossein Khaltabadi , Mohammadi Hossein , Moradi Mohammad Hossein
Published: May 2020

The objectives of this study were to identify genomic regions by Bayesian methods (BayesA, BayesB, or BayesN) that fit fixed-length haplotypes or SNPs using GenSel. Covariates for haplo-type alleles of five lengths (125, 250, 500 kb, 1 or 2 Mb) were generated, and rare haplotypes were removed at three thresholds (1, 5, or 10%). Subsequently, we performed gene network analyses to investigate the biological processes shared by genes that were identified for the same across traits. Genotypes at 41,034 SNPs that were common on OvineSNP50 panel were phased for 751 Scottish Blackface (SBF) lambs. This is the first study to quantify the proportion of genetic variance using haplotypes across the whole genome in an SBF population. The genetic variance explained of haplotype-based GWAS was higher than that of SNP-based GWAS in across traits studied. In this population, fitting 500kb haplotypes with a 1% frequency threshold resulted in the highest proportion of genetic variance explained for nematode resistance and fitting 2Mb haplotypes with a 10% frequency threshold improved genetic variance explained for body weight comparable to fitting SNPs by BayesB. Candidate genes, including CXCR4, STAT4, CCL1, CCL2, CCL3, CCL5, CCL8, CCL16, CCL18, CARMIL2, and HSPA14 were identified for nematode resistance and ADH5, PPP3CA, and FABP4 for body weight traits. Network analysis provided annotation results linking to all identified candidate genes. This study supported previous results from GWAS of nematode resistance and body weight and revealed additional regions in the ovine genome associated with these economically important traits. These results suggest that network analysis can provide new information regarding biological mechanisms and genes leading to complex phenotypes, like nematode resistance and body weight of lamb.
The insecticidal activity of the endophytic fungus Isaria fumosorosea Wize isolated from the leaves of the Ricinus communis L. against Locusta migratoria L. and Acanthoscelides obtectus Say
Authors: Laib Djamel Eddine , Benzara Abdelmadjid , Akkal Salah
Published: May 2020

This study was conducted to evaluate the insecticidal activity of the endophytic fungus Isaria fumosorosea Wize isolated from Ricinus communis L. against Locusta migratoria L. and Acanthoscelides obtectus Say. To evaluate the insecticidal activity, a mixture of fungal extract and spore suspensions (1x107, 1x106 and 1x105 spores/ml of dissolved extract) were applied against the insects. It was found that I. fumosorosea had a good insecticidal activity, positively proportional to concentration and time after exposure (24, 48, 72 hours). A maximum mortality rate of 80% for A. obtectus and 70% for L. migratoria at 1x107 spores/ml of dissolved extract was recorded. Preliminary phytochemical analyses of the fungal extract revealed the presence of alkaloids, flavonoids and phenols. Additionally, a fungal development on the insects bodies has also been noticed; that is undoubtedly explained the recorded insecticidal activity.
The influence of extraction method on antioxidant potential of Tilia argentea flowers and bracts
Authors: Ayaz Seyhan Serap , Yilmaz Zümrüt , Çikla Yilmaz Deniz
Published: May 2020

The objective of this work was to compare the extraction of phenolic compounds from Tilia argentea flowers and bracts by using conventional (solvent extraction) and novel (ultrasound assisted) extraction methods. Ethanol (70 %) extracts were analyzed for their antioxidant activities. Total phenolic content was determined using Folin-Ciocalteu method and the antioxidant potential was determined by DPPH radical scavenging and Ferric Reducing Antioxidant Power (FRAP) assays. To determine the effect of ultrasound treatment on the extraction, same extraction parameters were applied in both methods. The results showed that extracts obtained by ultrasound assisted extraction have higher total phenolic content and antioxidant activity.
Maximal functions for Weinstein operator
Authors: Abdelkefi Chokri
Published: May 2020

In the present paper, we study in the harmonic analysis associated to the Weinstein operator, the boundedness on L

p
of the uncentered maximal function. First, we establish estimates for the Weinstein translation of characteristic function of a closed ball with radius ɛ centered at 0 on the upper half space ℝd–1× ]0, +∞ [. Second, we prove weak-type L
1-estimates for the uncentered maximal function associated with the Weinstein operator and we obtain the L

p
-boundedness of this operator for 1 < p ≤ + ∞. As application, we define a large class of operators such that each operator of this class satisfies these L

p
-inequalities. In particular, the maximal operator associated respectively with the Weinstein heat semigroup and the Weinstein-Poisson semigroup belong to this class.
On dilation and commuting liftings of n-tuples of commuting Hilbert space contractions
Authors: Burdak Zbigniew , Grygierzec Wiesław
Published: May 2020

The n-tuples of commuting Hilbert space contractions are considered. We give a model of a commuting lifting of one contraction and investigate conditions under which a commuting lifting theorem holds for an n-tuple. A series of such liftings leads to an isometric dilation of the n-tuple. The method is tested on some class of triples motivated by Parrotts example. It provides also a new proof of the fact that a positive definite n-tuple has an isometric dilation.
Approximate multi-Jensen-cubic mappings and a fixed point theorem
Authors: Ramzanpour Elahe , Bodaghi Abasalt
Published: May 2020

In this paper, we introduce multi-Jensen-cubic mappings and unify the system of functional equations defining the multi-Jensen-cubic mapping to a single equation. Applying a fixed point theorem, we establish the generalized Hyers-Ulam stability of multi-Jensen-cubic mappings. As a known outcome, we show that every approximate multi-Jensen-cubic mapping can be multi-Jensen-cubic.
Sensitivity of Aerodynamic Characteristics of Paraglider Wing to Properties of Covering Material
Authors: Maślanka Paulina , Korycki Ryszard
Published: May 2020

The paper is theoretically oriented. The main goal is to analyze the sensitivity of aerodynamic characteristics to the properties of the material used for paraglider wing. The paraglider of considerable dimensions is designed without stiffening elements. Thus, the covering material yields adequate pressure distribution between the external and internal parts of the wing. The problem is solved using a geometrical model approximated by the dimensionless coordinates of crucial points and smoothed by spline curves. The finite volume mesh is defined using the Ansys Meshing program. Numerical analysis uses five different covering materials, ranging from the air-impermeable covering to the covering subjected to hydrolytic—mechanical degradation. Optimization of properties of the covering material improves the lift force and the aerodynamic characteristics of the wing. Moreover, numerical modeling is more beneficial and efficient than prototype tests. The obtained pressure distributions and other parameters explain the aerodynamic safety of the paraglider during dynamic conditions of flight.
The Influence of Brand on Consumer Quality Assessment of Clothes: A Case Study of the Polish Market
Authors: Salerno-Kochan Renata , Turek Paweł
Published: May 2020

This article presents the results of research carried out based on consumer assessment of the quality of clothing using sensory analysis. The study aimed to determine the role of the brand and information about it in assessing product quality and identify the quality parameters that distinguish brands of a similar quality level. An attempt was also made to classify popular brands of clothing available on the Polish market based on the parameters that determine their quality. A significant impact of the brand name on the sensory assessment of clothes’ quality has been reported. The study has shown that assessors attribute higher rating values to quality features when they know the product brand; moreover, the brand and its information shortens the assessment time, which may suggest that it simplifies and facilitates consumers’ decision-making process. The result analysis has led to the identification of three groups of the factors determining the quality of clothing products: fabric composition, workmanship, and all other variables. It has also led to the separation of three clusters, characterized by different levels of product quality, for which sets of features distinguishing a given category were determined.
Influence of power and maximal strength training on thermal reaction and vertical jump performance in Brazilian basketball players: a preliminary study
Authors: Corte Jaime Della , Pereira Wendell Luiz M. , Corrêa Eduardo Emil Lacerda S. , de Oliveira João Gabriel Miranda , Lima Bruno Lucas Pinheiro , de Castro Juliana Brandão Pinto , Lima Vicente Pinheiro
Published: May 2020

Study aim: To evaluate the effect of power and muscle strength training on skin temperature and the performance of the vertical jump with countermovement (CMJ).

Material and methods: The sample consisted of four male basketball athletes of the under-17 category (age: 15.75 ± 1.0 years). 48 hours after anthropometric evaluation and determination of the loads for 1 repetition maximum (1RM) in the leg extension exercise, the athletes were subjected, through crossover-type entrance, to power (PTP) and strength (STP) training protocols. The protocols consisted of three sets with loads of 60% and 90% of 1RM for PTP and STP, respectively. Thermographic images of the thighs were taken before and immediately after each training session.

Results: There were significant differences in results between the two training protocols, with increased total repetitions (t = 13.481; p < 0.05) and total training volume (t = 15.944; p < 0.05) in the PTP, and increase in the % of 1RM (t = 33.903; p < 0.05) and rating of perceived exertion (t = 6.755; p < 0.05) in the STP. The skin temperature before and after PTP and STP showed no significant differences. In the post-STP, the CMJ presented significant reductions in height (t = 3.318; p < 0.05), flight time (t = 3.620; p < 0.05), velocity (t = 3.502; p < 0.05), and force (t = 4.381; p < 0.05). There were no significant differences in pre-and post-STP CMJ.

Conclusions: Power and maximum strength training in the leg extension exercise performed until concentric failure appears to be a method that induces thermal stress on the skin. This training directly influenced the performance of the vertical jump after the stimulus.