bluuebunny/crossref_metadata_2025 huggingface dataset:
Tea Growing in the Florida Home Landscape
Authors: Crane Jonathan H. , Balerdi Carlos F.
Published: September 2021

HS-1058, a 6-page fact sheet by Jonathan H. Crane and Carlos F. Balerdi, provides homeowners with a basic reference for growing tea in the home landscape. Tables include suggested cultural practices by month and nutritional values. Published by the UF Department of Horticultural Sciences, November 2005.
HS1058/HS308: Tea Growing in the Florida Home Landscape (ufl.edu)
THE EFFECT OF NEBULIZED SALBUTAMOL ON SERUM POTASSIUM AND BLOOD SUGAR LEVEL OF ASTHMATIC PATIENTS
Authors: Bakolia Sushil Kuamr , Verma Gajendra Kumar , Barolia Dinesh Kumar
Published: September 2021

Background: To evaluate the effect of nebulized salbutamol used in the management of patients with asthma who have normal serum potassium and blood glucose levels.

Methods: Hospital based prospective study conducted on 30 children mild exacerbation of asthma who needed two doses of 2.5 mg nebulized salbutamol, 10 minutes apart for the relief of their symptoms will be include.

Results: The potassium mean was significantly decreased after 1 hour of nebulizer administration. The random blood sugar mean was significantly increased after 1 hour of nebulizer administration (p<0.001).

Conclusions: The nebulizer applying salbutamol has a profound effect in lowering the Potassium level and increasing blood glucose level after 60 minutes of administration.

Keywords: effect, nebulized, salbutamol, blood sugar, serum potassium
UNESCO Dünya Mirası Listesindeki Destinasyonların Yer Aldığı İllerin Turizm Potansiyelinin Değerlendirilmesi
Authors: ARSU Talip , SERİN KARACAER Serap
Published: September 2021

1980’li yıllar ile birlikte turizm endüstrisinde yaşanan gelişmeler ve buna bağlı olarak tüketici tercihlerinde meydana gelen değişimler sonucunda turizm endüstrisinde 3S olarak kabul edilen “deniz-kum-güneş (sea-sand-sun)” turizminin meydana getirdiği kitle turizmi anlayışının, yerini çeşitli faaliyetler ve farklı deneyimler sunan alternatif turizm olanaklarına bıraktığı görülmektedir. Bu bağlamda “kültür” odaklı gerçekleştirilen aktiviteler çerçevesinde şekillenen “kültürel miras turizmi” faaliyetlerinin, destinasyonlar açısından öne çıkan alternatif turizm olanaklarından birisi olduğunu ifade etmek mümkündür. Bu noktadan hareketle bu çalışmada, UNESCO Dünya Mirası Listesinde yer alan ve dolayısıyla da kültürel miras turizmi olanaklarına sahip destinasyonların bulunduğu illerin turizm potansiyellerinin değerlendirilmesi amaçlanmıştır. Bu değerlendirme gerçekleştirilirken Çok Kriterli Karar Verme (ÇKKV) yöntemlerinden CRITIC ve MAIRCA kullanılmıştır. Öncelikle kriterler objektif bir ÇKKV yöntemi olan CRITIC kullanılarak ağırlıklandırılmıştır. Sekiz kriterin kullanıldığı çalışmada en önemli kriterler sırasıyla yatak sayısı, otel sayısı ve müze sayısı olarak bulunmuştur. CRITIC yöntemi ile ulaşılan kriter ağırlıkları kullanılarak MAIRCA yöntemi ile iller sıralanmıştır. Turizm potansiyeli açısından sırasıyla en başarılı iller İstanbul, Muğla, İzmir, Bursa ve Aydın, en başarısız iller ise Karabük, Sivas, Kars, Çorum ve Adıyaman olmuştur. Son olarak kullanılan ÇKKV yöntemlerinin tutarlılığını ve doğruluğunu test etmek için duyarlılık analizi yapılmıştır.
Енергетична ефективність використання Тладіанти сумнівної як підщепи у процесі вирощування огірка Козіма F1 у гідропонних купольних теплицях
Authors: Ковальов М.М.
Published: September 2021

Пріоритетним напрямом на сучасному етапі розвитку овочівництва є отримання високоякісної, екологічно безпечної продукції в комплексі з розробленням і впро- вадженням нових агротехнічних прийомів вирощування. Перспективними є ті, які можуть суттєво розширити асортимент вирощуваних культур, кінцевою метою яких є урізноманітнення харчування населення. Натепер пер- спективний пошук нових високоефективних і екологічно безпечних технологій вирощування овочевих рослин, великого значення набувають біологічні методи впливу на рослинний організм. Одним із таких методів є засто- сування щеплення. Мета досліду – визначити енер- гетичну ефективність вирощування огірка на підщепі Тладіанти сумнівної гідропонним способом у купольних теплицях. Методи. Досліди проводили в умовах геоку- польних плівкових теплиць у зимово-весняній сівозміні. Результати. За результатами досліджень в умовах гео- купольних плівкових теплиць обґрунтовано можливість використання Тладіанти сумнівної як підщепи під час вирощування гібрида огірка на різних типах субстратів із використанням проточних гідропонних систем. У резуль- таті досліджень встановлено, що без використання під- щепи найкращі економічні показники зафіксовано в разі використання як субстрату ЕМ компосту та кокосового волокна. Одержано прибуток – 380,3 грн/м2, рівень рен- табельності – 238,2%; собівартість продукції – 59,1 грн/ кг, урожайність – 2,7 кг/м2. На тлі використання підщепи найкращі економічні показники (прибуток – 433,7 грн/м2; рівень рентабель- ності – 260,8%; собівартість продукції – 55,4 грн/кг, уро- жайність – 3,0 кг/м2) одержано в разі використання як субстрату агроперліту. Вирощування на інших субстра- тах призводило до зниження врожайності й економіч- ної ефективності виробництва. За виходом з 1 гектара у варіантах без використання підщепи за всіма показ- никами найкращим варіантом є субстрати ЕМ компосту та кокосового волокна, коефіцієнт їхньої енергетичної ефективності – 2,88, енергетичний коефіцієнт – 1,95. Дещо вищі ці коефіцієнти з використанням підщепи та субстрату з агроперліту – 3,13 та 2,12 відповідно. Висновки. Максимальну загальну врожайність плодів огірка, у середньому за досліджуваний період, на рівні 16,3 кг/м2 отримали з рослин, вирощених на субстраті з агроперліту з використанням підщепи Тладіанти сум- нівної, що перевищувало контроль 13,5 кг/м2 на 18,2%. У середньому за роки досліджень на врожайність огірка гібрида Козіма F1 помітно вплинули склад субстрату та використання підщепи Тладіанти сумнівної, оскільки параметри кліматозабезпечення були однотипними для всіх варіантів.
Сучасні проблеми формування якості води Інгулецької зрошувальної системи в разі застосування промивки річки Інгулець упродовж квітня – серпня та шляхи їх вирішення
Authors: Козленко Є.В. , Морозов О.В. , Морозов В.В.
Published: September 2021

Мета. Дослідити фактичний стан процесу форму-вання якості води на Інгулецькій зрошувальній системішляхом здійснення промивок річки Інгулець за останні10 років (2011–2020 роки), визначити наявні проблемита шляхи їх вирішення. Методи. Системний підхіді системний аналіз даних, узагальнення, порівняння,зворотний зв’язок, польові та лабораторні дослідження.Результати. Із 2011 року дотепер на Інгулецькій зро-шувальній системі застосовується варіант формуванняякості води «Промивка зверху на весь поливний період»:задовільна для зрошення якість води формуєтьсяу джерелі зрошення – річці Інгулець шляхом здійсненняпостійних попусків води з Карачунівського водосховищаіз квітня по серпень витратами 20,0–9,0 м3/с загальнимобсягом не менш ніж 120 млн м3. Виконано дослідженняфактичного виконання реґламентів промивання руслай екологічного оздоровлення річки Інгулець та дослі-дження якості води за вмістом хлоридів по гідропостуАндріївка. У результаті досліджень визначено відсотокдіб, у які вміст хлоридів у воді річки Інгулець перевищу-вав значення 350, 400, 450, 500 мг/дм3 (з урахуваннямтермінів початку та закінчення промивок та з урахуван-ням термінів добігання води). Відсоткове середньо-річне співвідношення діб, у які якість води за вмістомхлоридів перевищує 350 мг/дм3, у 2018–2020 рокистановить 68,71%, у 2011–2017 роки – 17,37%; вище400 мг/дм3 – відповідно 33,28 та 2,86%; вище450 мг/дм3 – відповідно 20,47 та 0,88%; вище 500 мг/дм3 –відповідно 14,38 та 0,55%. Висновки. Дослідженнямидоведено, що у 2018–2020 роках спостерігається зна-чне погіршення якості води річки Інгулець, отже, і зро-шувальної води в Інгулецькому магістральному каналі,порівняно із 2011–2017 роками, що може призвести донегативного впливу на сільськогосподарські культурий активувати процеси деградації ґрунтів. Головною при-чиною є неповне дотримання Реґламенту промиваннярусла та екологічного оздоровлення річки Інгулець,а саме зменшення витрат попусків промивної водиз Карачунівського водосховища та пуск у роботу Головноїнасосної станції до моменту досягнення нормативноїякості води в річці Інгулець (2020 рік). Рекомендованонадалі обов’язково фіксувати в Реґламенті граничнуконцентрацію хлоридів у воді річки Інгулець (350 мг/дм3) упродовж усього поливного періоду та чітко визначатиреальний дієвий механізм дотримання та контролюза дотриманням зазначеної вимоги. Шляхами подаль-ших досліджень є більш повне дослідження зв’язкуміж наповненням балки Свистунова шахтними водамита якістю води в річці Інгулець. Необхідні також ство-рення експертної системи й організація цільового моні-торингу формування відповідної якості води в річціІнгулець та в магістральному каналі Інгулецької зрошу-вальної системи.
Development of Antenatal Care Pamphlet in Burmese
Authors: Tanabatchai Piamboon , Upakdee Nilawan , Chaijinda Kultida
Published: September 2021

Background: Currently, there are many foreign workers working in Thailand. Majority of them are Myanmar. Providing information on antenatal care to Burmese women is one of the guidelines in providing knowledge for antenatal care.

Objective: To develop a pamphlet on antenatal care in Burmese language.

Methods: This study was on research and development. The tools used in the research were the pamphlet development and pamphlet evaluation forms. The back translation method was used for translation by using Thai language pamphlet that modifies for the optimal features and information appropriate for the clients.

Results: The process of translating and developing research tools was started from Step 1: translating the contents of pamphlet from Thai to Burmese, obtaining the pamphlets B1 and B2. Step 2: conducting a preliminary test by bringing the two Burmese language pamphlets to test with the participants that can communicate in Burmese language and evaluate the pamphlet features. It was found that the majority of 3 in 5 people were satisfied with the B2 pamphlet at an excellent level. This step aimed to consider the clarity of the language idioms used. Step 3: reviewing the suitability of the culture by introducing the Burmese pamphlet and preliminary tests checked by experts who understand the context and culture of Myanmar. Step 4: synthesizing the translated version of the tool by collecting information that is appropriate for the context and culture of the Burmese people to synthesize as a new Burmese pamphlet. Step 5: translating the contents of the pamphlet back from Burmese to Thai language. And Step 6: checking the equality of translation and draw conclusions.

Conclusions: From all processes mentioned above, we got the Burmese antenatal care pamphlet that is appropriate in terms of content and culture.
Prevalence, Types, and Factors of HPV Infection Among Women With Abnormal Cervical Cytology Screening at Ramathibodi Hospital
Authors: Boonthum Nithitda , Suthutvoravut Somsak
Published: September 2021

Background: Cervical cancer is the second leading cancer among Thai women. Human papillomavirus (HPV) is the most common cause of cervical cancer. HPV16 and HPV18 are the most prevalence types in women with cervical cancer.

Objectives: To study the prevalence and types of HPV infection and its associated risk factors among women with abnormal cervical cytology screening.

Methods: This cross-sectional study purposively recruited 376 women who had abnormal cervical cytology screening by liquid-based cytology at the outpatient clinic, Ramathibodi Hospital from August 2015 until March 2016. HPV genotyping was done by the polymerase chain reaction (PCR). Analysis of the personal characteristics was done using descriptive statistics.

Results: The prevalence of HPV infection was 41.5%. Among them, a single infection was found in 78.8% of women. The most common genotypes were HPV16 (8.5%) and HPV52 (7.7%). But HPV18 was found in only 1.9%. The characteristic which was significantly associated with HPV infection was age, nulliparity, and high-graded dysplasia (P < .05).

Conclusions: High prevalence rate of HPV infection was found among women with abnormal cytology. High-risk HPV prevalence and type distribution may be useful for public health authorities in assessing the cervical screening program.
The price behavior of the MGO bunker market: An integrated causality and interpretive structural modeling approach
Authors: Açık Abdullah
Published: September 2021

Marine fuel price differences of supply centers have a significant effect on operators’ budgets, and so are closely monitored by traders, charterers and shipowners. The aim of this study is to determine the volatility spillovers between the prices of the major fuel centers in the world and to form a hierarchical structure based on the influence and dependence powers of these centers. For this purpose, an integrated structure of causality in variance and Interpretive Structural Modeling (ISM) methods are used. The data set used in this study includes marine gas oil (MGO) prices for 8 fuel centers used extensively in the world, namely: Fujairah, Hong Kong, Houston, Istanbul, New York, Piraeus, Rotterdam, and Singapore. This data consists of 782 daily observations covering a 3-year-period between 14.04.2017 and 13.04.2020. The ISM results reveal that these fuel centers lie at 6 different levels based on their driving and dependence powers, sources of price volatility in the market are Fujairah and Singapore, and the center that is most affected by volatility is Piraeus. In addition to drawing a macro frame for the fuel market, the results obtained are thought to be useful in reducing risk in the market due to uncertainty for stakeholders.
Shipping pattern may be altered according to available refining capacity
Authors: Toppur Badri
Published: September 2021

Alternate optimal solutions in the mathematical programming solution of a real-world problem are rare, unless there are multiple objective functions. In a recent application of 2 mathematical programming solvers to a problem of crude oil logistics, I obtained 2 different optimal solutions. The almost optimal solutions obtained from the convex combinations of the 2 optimal solutions, are feasible as real transportation choices, if the optimal solutions cannot be implemented. It was observed that the 2 solutions led to different capacity utilization at the refineries downstream, and so do the many solution alternatives. This is useful information for the petroleum company during downtime for maintenance or capacity expansion.
Pilot Study on the Current Management of Children with COVID-19 In Hospitals in Bangladesh; Findings and Implications
Authors: Nusrat Nadia , Haque Mainul , Chowdhury Kona , Adnan Nihad , Lutfor Afzalunnessa Binte , Karim Enamul , Hassan Mahmuda , Rabbany Arif , Begum Dilara , Hasan Mohammad Nazmul , Sihan Nazmus , Zaman Sifat Uz , Islam Salequl , Schellack Natalie , Gowere Marshall , Kurdi Amanj , Godman Brian
Published: September 2021

Objective: The focus on COVID-19 in children in low- and middle-income countries including Bangladesh has been on addressing key issues including poor vaccination rates as well as mental health issues, domestic violence and child labour. However, the focus on optimally managing children in hospitals is changing with new variants and concerns with the development of hyperinflammatory syndromes. There are also concerns with the overuse of antimicrobials to treat patients with COVID-19 in hospitals enhancing resistance rates. The Bangladesh Paediatric Association have developed guidelines to improve patient care building on national guidance. Consequently, there is a need to document the current management of children with COVID-19 in Bangladesh and use the findings for future guidance.
Methods: Rapid analysis of the management of children with COVID-19 among eight private and public hospitals in Bangladesh with varying numbers of in-patient beds using purposely developed case report forms (CRFs). The CRFs were piloted before full roll-out.
Results: Overall low numbers of children in hospital with COVID-19 (4.3% of in-patient beds). The majority were male (59.6%) and aged 5 years or under (63.5%). Reasons for admission included respiratory distress/ breathing difficulties with 94.2% of COVID-19 cases confirmed. All children were prescribed antibiotics empirically, typically those on the Watch list of antibiotics and administered parenterally, with only a small minority switched to oral therapy before discharge. There was appreciable prescribing of Vitamins (C and D) and zinc and encouragingly limited prescribing of other antimicrobials (antivirals, antimalarials and antiparasitic medicines). Length of stay was typically 5 to 10 days.
Conclusion: Encouraging to see low hospitalisation rates and limited use of antimicrobials apart from antibiotics. Concerns with high empiric use of antibiotics and limited switching to oral formulations can be addressed by instigating antimicrobial stewardship programmes. We will be monitoring this.
Bangladesh Journal of Medical Science Vol.20(5) 2021 p.188-198
Tilaa, seuraa ja ohjattua toimintaa
Authors: Moll Veera , Jouhki Essi
Published: September 2021

Artikkelissa tutkitaan lapsille suunnattujen kaupunkiympäristöjen ja erityisesti ohjattujen leikkikenttien kehittymistä 1970-luvun Helsingissä. Lasten ympäristöjä ja niiden suunnitteluun vaikuttaneita lapsikäsityksiä tarkastellaan kolmen tason, rakennetun ympäristön, leikkikenttien arjen ja hyvinvointivaltion viitekehyksen kautta. Tutkimusaineistona on käytetty suunnitteludokumentteja, lapsista ja kaupunkiympäristöistä käytyä asiantuntijakeskustelua, sanomalehtikirjoituksia sekä entisten leikkikenttätoimijoiden kanssa tehtyjä haastatteluja. Artikkelissa esitetään, että lisääntyvistä lasten ympäristöjä koskevista normeista ja vähitellen kasvavasta valvonnasta huolimatta leikkikentät muotoutuivat joustavaksi ja lapsiystävälliseksi kaupunkitilaksi, joka mahdollisti sekä ohjatun että vapaan leikin. Suomalainen leikkikenttäkonsepti sai alkunsa Helsingissä, ja pääkaupunkiseudun esimerkki on vaikuttanut leikkikenttätoiminnan vakiintumiseen myös muualla Suomessa.
Changes in age-specific seroprevalence of Japanese encephalitis virus and impact of Japanese encephalitis vaccine in Korea
Authors: Kwak Byung Ok , Hong Young Jin , Kim Dong Hyun
Published: September 2021

The Japanese encephalitis (JE) virus is the leading cause of vaccine-preventable encephalitis in Asia. Since the introduction of a universal JE vaccination program and urbanization of Korea, the incidence of JE has dramatically decreased in Korea. However, recent JE cases have occurred, predominantly among unvaccinated adults and with a shift in age distribution. Here we aimed to review the changes in age-specific JE seroprevalence over time and discuss the implications of JE vaccination programs in Korea. Following the last epidemic in 1982–1983, mandatory vaccination for all children aged 3–15 years was conducted annually until 1994. However, JE has reemerged, predominantly affecting unvaccinated adults aged 40 years or older and demonstrating a shift in age distribution toward older populations. The age-specific seroprevalence of the JE virus in Korea has changed noticeably over time. Seropositivity in children and adolescents increased from 10%–59% in the 1970s to 90%–92% in the 1980s after the implementation of the JE vaccination program and increased further to 98% in 2012. No age-specific difference in the seroprevalence of JE was found, and appropriate levels of immunity to JE were maintained for all age groups. Continuous surveillance of the seroprevalence of JE is essential to establish a proper immunization policy in Korea.
Is fetal nuchal cord associated with autism spectrum disorder? A meta-analysis
Authors: Jenabi Ensiyeh , Ahmadi Maryam , Maleki Azam
Published: September 2021

Background: There is inconsistent evidence about the association between fetal nuchal cord and the risk of autism spectrum disorder (ASD). We performed a meta-analysis to investigate whether fetal nuchal cord is associated with an increased risk of ASD in offspring.Methods: Three main English databases were searched until January 2021. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using the I2 statistic, while publication bias was assessed using Begg and Egger tests. Results are presented as odds ratios (ORs) and relative ratios with 95% confidence intervals (CI) and were determined by a random-effects model.Results: Five articles (1 cohort, 4 case-control; 3,088 total children) were included in the present meta-analysis. Fetal nuchal cord was not a risk factor for ASD (OR, 1.11; 95% CI, 0.66–1.57). There was homogeneity among studies that reported a risk of ASD (I2=0.0%).Conclusion: Our results showed that fetal nuchal cord is not a risk factor for ASD. Future large cohort studies should confirm this finding.
Проектные решения фундаментов в условиях островного распространения многолетнемерзлых грунтов Магадана
Authors: ГУЛЫЙ Сергей Александрович
Published: September 2021

Город Магадан до последнего времени оставался одним из немногих городов, построенных в зоне многолетнемерзлых пород, где начиная с середины 1980-х гг. не было проблем, связанных с деформациями зданий и сооружений из-за осадок, вызванных оттаиванием мерзлого грунта. Первые каменные дома в Магадане начали возводить к середине 1930-х гг. С началом их строительства стало понятно, что механический перенос типовых решений фундаментов зданий, принятых для работы в талых грунтах, не обеспечивает требуемой надежности в оттаивающих грунтах. Только к началу 1980-х гг. появилась полная ясность, в каких мерзлотно-грунтовых условиях следует применять конкретный тип фундамента, гарантирующий устойчивость зданий. К сожалению, при современном проектировании зданий и сооружений на территории Магадана накопленный опыт строительства учитывается в малой степени или вообще не учитывается. В статье приводятся примеры фундаментов новых зданий, запроектированных без учета имеющегося опыта проектирования и строительства в специфических мерзлотно-грунтовых условиях Магадана, а также показываются последствия, к чему это может привести. Сделан вывод о том, что оптимальными по стоимости и надежности могут быть только те конструкции, проектирование которых основывается как на современных технологиях и передовых достижениях науки, так и на многолетнем опыте строительства на данной территории.
Волновая теория удара для контроля процесса погружения забивных свай
Authors: ФИЛИППОВ Кирилл Александрович , ЧУРКИН Алексей Андреевич , ГАВРЮТИНА Алина Владимировна , МУХИН Александр Алексеевич
Published: September 2021

Рассмотрены вопросы применения волновой теории удара для мониторинга процесса погружения забивных свай. Цель работы - анализ возможностей метода, основанного на принципах волновой теории удара, применительно к процессу устройства фундамента с использованием забивных свай. В задачи работы входило: проведение мониторинга процесса погружения свай в ходе натурных исследований для подтверждения соответствия их несущей способности проектным значениям, выявление возможности для оптимизации конструкции и определение повреждения сваи в ходе забивки. Работы на двух объектах выполнялись с помощью аппаратного комплекса производства США, для обработки данных использовались кейс- и бета-методы. Мониторинг процесса погружения свай на первом объекте демонстрирует резкое возрастание сопротивления погружению свай при их заглублении в несущий слой плотного песка, фактическая несущая способность почти вдвое превосходит проектное значение. Несущая способность сваи меньшей длины по результатам мониторинга также подтверждена статическими испытаниями одной из свай. Результаты мониторинга процесса погружения свай на первом объекте позволяют заключить, что метод, использующий принципы волновой теории удара, может успешно применяться для мониторинга процесса погружения забивных свай. Кроме того, полученные данные об изменении несущей способности сваи в зависимости от глубины ее погружения позволяют корректировать проектные решения для повышения их надежности и экономической эффективности. По результатам испытаний забивной составной сваи на втором объекте было выявлено ее разрушение, произошедшее в процессе забивки. Косвенным подтверждением этому служат данные журнала забивки свай. Успешно выявленное разрушение сваи на втором объекте подтверждает перспективность применения бета-метода для оперативного получения информации о возникающих в ходе погружения сваи дефектах. При качественном выполнении сварного соединения составной забивной сваи в месте стыка не наблюдается явлений, влияющих на результат применения бета-метода для выявления повреждения сваи.
Nutritional status of children with familial hypercholesterolemia
Authors: Polunina D. A. , Bagaeva M. E. , Pavlovskaya E. V. , Strokova T. V.
Published: September 2021

Aim. To study the features of the nutritional status, including physical growth, body composition, energy value of the diet and the amount of cholesterol consumed with food, in children with familial hypercholesterolemia (FH).

Patients and methods. The study included 39 children (19 girls, 20 boys) with familial hypercholesterolemia, both genetically confirmed (n = 11) and established on the basis of Simon Broome criteria (n = 28), aged 9.9 [6.0; 12.9] years. All children were assessed for physical growth based on the Z-score BMI, Z-score height, Z-score body weight/height calculated using the programs Anthro and Anthro plus; analysis of actual nutrition using a standard application program; study of body composition using the InBody 770 bioimpedance analyzer, the basal metabolic rate measured by indirect calorimetry.

Results. 55 % of children with FH had harmonious physical growth, 27 % had a body weight deficit, 18 % were overweight or obese. 53 % of patients consumed more than 200 mg of cholesterol per day, while half of them consumed more than 300 mg of cholesterol per day. The range of excess consumption of cholesterol in comparison to the recommended physiological needs for patints with FH ranged from 24 to 67 %. The fat mass according to the body composition in 47 % of patients with FH is within the normal range, in 39 % it is reduced by 18-74 %, in 14 % it is increased by 14-197 %. The median fat percentage was 17.8 [12.7; 22.4]%. According to indirect calorimetry, it was found that the level of resting energy needs corresponded to age needs in 21 % patients, in 8 % it was decreased of 2-26 %, in 2/3 of children its increase was recorded by 3-69 %. The rate of fat oxidation, on the contrary, was increased in 71 % of children by 3-86 % and reduced only in 6 %.

Conclusion. The physical growth of children with FH was mainly average, harmonious, while a third of the children had a mass deficit. The level of the main indicators of lipid metabolism did not depend on the physical growth of patients. This pathology in children with normal body weight or with a body weight deficit often remains undiagnosed.
Ecological and typological assessment of forest vegetation of the Middle Dnieper (Forest-steppe of Ukraine)
Authors: Solomakha I. , Chornobrov O.
Published: September 2021

The paper shows the importance of a detailed study of various aspects of modern phytodiversity as an essential element of preservation of natural ecotypes for building national ecological network in the system of pan-European network. To do this, it is necessary to explore various aspects of natural and spontaneously formed vegetation. Based on the ecological specifics of the Middle Dnieper (Forest-Steppe of Ukraine), a detailed analysis of natural and artificially formed forests on the Dnipro cliffs, in ravine-beam systems and on the Dnipro floodplain is required. Peculiarities of forest vegetation conditions, distribution of tree species and ecological conditions of their growth are given. According to forest management data, the area covered with forest vegetation is 251341.3 hectares. The distribution of forest areas by edatopes is as follows: trophotopes — subors (78083.2 hectares, 31.07%), sugruds (77232.6 hectares, 30.73%), oak wood (72520.6 hectares, 28.85%) and pine forests (23504.9 hectares, 9.35%); hygrotopes — fresh conditions (183792.4 hectares, 73.13%), dry (34938.5 hectares, 13.90%), damp (19038.7 hectares, 7.57%), moist (11401.1 hectares, 4.54%), wet (1896.0 hectares, 0.75%) and very dry conditions (274.6 hectares, 0.11%). There are 62 types of forests areas covered with forest vegetation, which are dominated by fresh oak-pine forest (68319.9 hectares, 27.18%) and hornbeam oak wood (32871.8 hectares, 13.08%), a slightly smaller area occupied by fresh pine forest (17568.3 hectares, 6.99%), hornbeam-oak-pine sugrud (16952.2 hectares, 6.74%), maple-linden forest (15144.4 hectares, 6.03%) hornbeam-pine (13775.4 hectares, 5.48%) and hornbeam (9334.3 hectares, 3.71%) sudibrovas and dry maple-linden forest (12810.9 hectares, 5.10%). The composition of forest-forming species is quite diverse and is represented by 71 species of woody and shrubby plants. The main forest-forming species are Pinus sylvestris (116592.9 hectares, 46.39%) and Quercus robur (60049.7 hectares, 23.89%). Robinia pseudoacacia (26406.0 hectares, 10.51%), Alnus glutinosa (11391.7 hectares, 4.53%) and Fraxinus excelsior (7835.5 hectares, 3.12%) have slightly smaller areas, all other species occupy small areas. Identifying all the diversity of forest habitats will provide an opportunity to plan the conservation, reproduction and protection of phytodiversity, including species of sozophytes from different conservation lists, as well as to balance the provision of ecosystem services by tree plantations of the Middle Dnieper.
Current state and prospects of certification of Chernihiv region forest resources
Authors: Tertychna O. , Ryabukha G. , Miroshnyk N. , Kudriashova К.
Published: September 2021

The article examines the importance of the forestry complex for maintaining the natural balance and conservation of biodiversity from an ecological point of view, and compliance with international standards and access to international markets from an economic point of view. The areas covered with forest vegetation, as well as the forest cover of the territories of European countries and Ukraine were analyzed. The deviation of the actual average forest cover of the territory from the optimal one in Ukraine (by 4.1%) was revealed. Zonal indicators of Ukraine’s forest cover were considered, and the territories of the country with insufficient afforestation were identified. The importance of forest certification for ensuring economically and ecologically balanced forest management was considered. The positive dynamics according to the area of the certified forests, growth rates of the area, growth rates of the number of forestry certificates, and supply chain certificates among Ukrainian producers was analytically confirmed. Forestry activity in Chernihiv region in 2015–2020 was analyzed according to the area of certified forests, types of forest vegetation, and afforestation areas. The current FSC certified state-owned enterprises of Chernihiv region are also identified: Novhorod-Siversky Forestry, Nizhyn Forestry, Kholmy Forestry and certified products (roundwood logs), wood chips, sawdust, fuel wood, beams, planks, and finished dimensional lumber) and promising areas of certification (twigs, plank flooring, wood wool, pallets, etc.) were identified. The long-term benefit of FSC certification for domestic forests has been proved. It was determined and reasoned that forest certification is a tool to increase the competitiveness of domestic forests and integration into foreign markets.
Bioindication of soil of unauthorized landfills in the Carpathian region
Authors: Symochko L. , Hafiiyak О. , Demyanyuk O.
Published: September 2021

The article presents the results of monitoring the area adjacent to the Carpathian Biosphere Reserve for the detection of unauthorized landfills and examines the ecological status of these soils. Four unauthorized landfills of solid waste in Pidhirna, Stanislav, Steryshora, and Feresok tracts with an area of 0.15 to 1.5 ha with a waste accumulation period of 12–22 years and different morphological composition which had a significant impact on the ecological status of the soil have been identified. Bioindication methods have shown changes in the soil microbial cenoses under the direct influence of unauthorized landfills of solid waste, namely increased the number of organotrophic bacteria and micromycetes and decreased number of nitrogen-fixing microorganisms. The highest number of bacteria using nitrogen of organic compounds (25.36–28.61 million CFU/g soil) and micromycetes (51.8–76.8 thousand CFU/g soil) was fixed in the soils in the tract PidhirnaandFeresok with advantage of 1.5–1.7 times and 2.5–3.8 times compared to the soil of the protected area. Increasing the number of pedotrophic and oligotrophic microorganisms and microorganisms that assimilate organic forms of nitrogen, on average, 2.70, 2.84 and 1.48 times has been affected the direction of the main soil-microbiological processes. The coefficient of oligotrophicity varied in the range of 0.21–0.30, mineralization-immobilization one — 1.22–1.38, pedotrophic one — 0.55–0.96 with a maximum in the soil of the landfill in the tracts of Feresok and Pidhirna, which indicates the strengthening of microbiological processes of mineralization and decomposition of soil organic matter, including humus compounds. A close relationship was established between the duration of solid waste storage in a certain area and the level of soil phytotoxicity (r = 0.92). In the soil of landfills in Pidhirna, Steryshora and Feresok tracts, the phytotoxicity index is significant (over 50%), which indicates a high level of soil ecosystem pollution and increased environmental risks in the area of unauthorized accumulation of solid waste.
Analysis factors affecting formation on the clutch durability between asphalt-concrete layers of road clothing
Authors:   National Transport University, Levkivska Liydmyla , Elallak Jafar Musa
Published: September 2021

This article reflects the importance of the road network for the social development of society and the development of the economy of the country as a whole. On the basis of literary sources provides complex analysis of roads in Ukraine, their current functional state and tendencies of development. It is established that the road industry is in a rather difficult situation due to unsatisfactory transport and operational conditions of the vast majority of Ukrainian roads. Construction of new roads is extremely rare because of lack of financial resources. Road works are usually carried out to preserve the network of already existing roads and to ensure their necessary transport and operational status. According to the results of the analysis, one of the main reasons for the premature destruction of newly constructed or repaired non-rigid pavements is the low strength of interlayer adhesion in the contact area of the newly covered material with the layer below. The effect of clutch durability between asphalt layers on the road strength has been studied in detail. A number of factors that affect the quality of clutch durability between layers are analyzed. It is established that in order to ensure the strength of grafting between asphalt concrete layers of road clothing, it is necessary to strictly observe the technological regimes of their laying, above all temperature; to take into account the physical and mechanical properties of materials at the construction stage and the influence of climatic and mechanical factors, or most often their complex effect on the operation of the highway.
Determination of normative values of mechanical indicators of bonded soils based on dynamic probing data
Authors:   State Enterprise ", Lytvynenko Anatoаlii ,   M.P. Shulgin State Road Research Institute", Kushnirova Oksana ,   National Transportation University
Published: September 2021

In the work on the basis of analytical analysis of tabular data, both current and previous domestic regulatory documents on civil engineering, for mechanical indicators of bonded soils of natural occurrence graphic and analytical (formula) interpretation of these values in relation to the values of the dynamic probing index of Pd, MPa, and yield index IL, units, for the degree of water saturation of these soils Sr ≥ 0.8 units is given. Correlation with the value of dynamic probing of Pd, MPa allows not only to differentiate engineering and geological (geotechnical) cross-sections, more or less detailed, but also to estimate the load-bearing capacity of selected layers of bonded soils accurately enough. The theoretical analysis has shown that the values of mechanical indicators of natural bonded soils adopted in the current regulatory documents, even taking into account their structural strength, can not be directly used as a prototype to assess similar indicators of compacted technogenic soils of artificial structures in the form of embankments of hydraulic dams, road embankments or airfields. This is due to the fact that in the vast majority of cases in civil construction assessed the properties of soils in the plastic state, which tend to have a lower density of dry soil than at the border of rolling, and a mandatory condition for the use of such soils in artificial soil structures is their compliance with the requirements of the so-called standard compaction, that is, the density of dry soil there should be more than the density of dry soil at the border of rolling. These soils are in a solid state (their concentration is ≥ 85 %) and indeed (through direct contact between the soil parts) work as an elastic body and can be characterized by a modulus of elasticity with a corresponding small elastic deflection lmax and a sufficiently large design critical resistance value of R0 ≥ 0.6 MPa, which must be determined at each laboratory test of the samples before they fracture or disproportional movement of the stamp.
Queer Political Representation: A Phenomenological Approach
Authors: Norris Haley
Published: September 2021

This paper presents queer phenomenology as a way to study political representation of LGTBQ populations.
The Impact of Lymphedema Therapy on Quality of Life: A Case Report
Authors: Carter III Cleve , Andrews Alexis
Published: September 2021

Background and Purpose: Lymphedema is a chronic inflammatory lymphostatic disease known as the buildup of lymph fluid in the fatty tissues that can cause swelling and discomfort in the arms, legs, face, neck, trunk, abdomen, and genitals [1]. Failure of the lymphatic system causes lymphedema [1]. Lymphedema may reduce the quality of life and may progress as well as cause other complications such as cellulitis if untreated [1]. Although there is no cure for lymphedema, there are interventions to reduce or manage the swelling and the discomfort [1]. The purpose of this study is to show that a patient with lymphedema can improve their quality of life significantly with adequate lymphedema therapy interventions using Complete Decongestive Therapy (CDT). Method and Procedures: A 47-year-old African American female patient presented to outpatient physical therapy with a report of experiencing bilateral lower extremity swelling for about ten years. To determine the effects of the treatments, the lymphedema therapist examined the patient using the following tests and measures and outcome measurement tools: Bilateral Girth Measurements, the Lymphedema Life Impact Scale Version 2 (v2), and the Global Rating of Change (GRoC) Scale. The patient attended physical therapy sessions 2 times per week for 3 weeks not including the date of initial evaluation. Thus, the patient attended five treatment sessions. The patient actively participated in the creation of the current goal: to decrease bilateral lower extremity swelling. Results: On discharge assessment (6th visit), the patient reported a reduction in pain to (3/10). The patient scored a 12/68 on the Lymphedema Life Impact Scale (v2) indicating that her quality of life had improved significantly within the past three weeks since receiving lymphedema therapy services. The patient made excellent progress, demonstrated marked improvements with involved extremities lymphatic circulation, and decreased swelling with girth measurements. The patient reported significant improvements with functional activities of daily living such as standing, sitting to standing, and walking. The patient also reported that her quality of life improved significantly.
Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage
Authors: Feng Meng , Liu Wenguang , Ding Jing , Qiu Yusheng , Chen Qian
Published: September 2021

Hedgehog (HH) signaling plays a critical role in osteoarthritis (OA) pathogenesis, but the molecular mechanism remains to be elucidated. We show here that Sonic Hedgehog (SHH) gene expression is initiated in human normal cartilage stromal cells (NCSC) and increased in OA cartilage mesenchymal stromal cells (OA-MSCs) during aging. Manifesting a reciprocal cellular distribution pattern, the SHH receptors PTCH1 and SMO and transcription factors GLI2 and GLI3 are expressed by chondrocytes (OAC) in OA cartilage. SHH autocrine treatment of osteoarthritis MSC stimulates proliferation, chondrogenesis, hypertrophy, and replicative senescence with elevated SASP gene expression including IL1B, IL6, CXCL1, and CXCL8. SHH paracrine treatment of OAC suppresses COL2A1, stimulates MMP13, and induces chondrocyte apoptosis. The OA-MSC conditioned medium recapitulates the stimulatory effects of SHH on OAC catabolism and apoptosis. SHH knock-down in OA-MSC not only inhibits catabolic and senescence marker expression in OA-MSC, but also abolishes the effect of the OA-MSC conditioned medium on OAC catabolism and apoptosis. We propose that SHH is a key mediator between OA-MSC and OA chondrocytes interaction in human OA cartilage via two mechanisms: (1) SHH mediates MSC growth and aging by activating not only its proliferation and chondrogenesis, but also low-grade inflammation and replicative senescence, and (2) SHH mediates OA-MSC-induced OAC catabolism and apoptosis by creating a pro-inflammatory microenvironment favoring tissue degeneration during OA pathogenesis.
An Adipose-Derived Injectable Sustained-Release Collagen Scaffold of Adipokines Prepared Through a Fast Mechanical Processing Technique for Preventing Skin Photoaging in Mice
Authors: Jin Xiaoxuan , Zhang Yuchen , Zhang Xiangdong , Li Yibao , Xu Mimi , Liu Kaiyang , Ru Jiangjiang , Ma Chijuan , Yao Yao , He Yunfan , Gao Jianhua
Published: September 2021

Ultraviolet A (UVA) radiation is the major contributor to skin photoaging, associated with increased collagen degradation and reactive oxygen species (ROS) expression. Adipokines have been proven as promising therapeutic agents for skin photoaging. However, adipokine therapy is generally limited by the short in vivo release duration and biological instability. Therefore, developing a treatment that provides a sustained release of adipokines and enhanced therapeutic effects is desirable. In this study, we developed a novel mechanical processing technique to extract adipose tissue-derived ECM components, named the “adipose collagen fragment” (ACF). The physical characterization, injectability, collagen components, residual DNA/RNA and adipokine release pattern of ACF were identified in vitro. L929 cells were treated with ACF or phosphate-buffered saline for 24 h after UVA irradiation in vitro. The expression of senescence-associated xβ-galactosidase (SA-β-gal), ROS and antioxidase were investigated. Then, we evaluated its therapeutic efficacy by injecting ACF and phosphate-buffered saline, as a control, into the dermis of photoaging nude mice and harvesting skin samples at weeks 1, 2, and 4 after treatment for assessment. The content of adipokines released from ACF was identified in vivo. The collagen synthesis and collagen degradation in ACF implants were evaluated by immune staining. Dermal thickness, fibroblast expression, collagen synthesis, ROS level, antioxidase expression, capillary density, and apoptotic cell number were evaluated by histological assessment, immune staining, and polymerase chain reaction in the skin samples. We demonstrated that ACF is the concentrated adipose extracellular matrix collagen fragment without viable cells and can be injected through fine needles. The lower expression of SA-β-gal, ROS and higher expression of antioxidase were observed in the ACF-treated group. ACF undergoes collagen degradation and promotes neocollagen synthesis in ACF implants. Meanwhile, ACF serves as a sustained-release system of adipokines and exhibits a significantly higher therapeutic effect on mouse skin photoaging by enhancing angiogenesis, antioxidant abilities, antiapoptotic activities, and collagen synthesis through sustainedly releasing adipokines. To sum up, ACF is an adipokines-enriched, sustained-release extracellular matrix collagen scaffold that can prevent UVA-induced skin photoaging in mice. ACF may serve as a novel autologous skin filler for skin rejuvenation applications in the clinic.
Transcriptomics and Other Omics Approaches to Investigate Effects of Xenobiotics on the Placenta
Authors: Rosenfeld Cheryl S.
Published: September 2021

The conceptus is most vulnerable to developmental perturbation during its early stages when the events that create functional organ systems are being launched. As the placenta is in direct contact with maternal tissues, it readily encounters any xenobiotics in her bloodstream. Besides serving as a conduit for solutes and waste, the placenta possesses a tightly regulated endocrine system that is, of itself, vulnerable to pharmaceutical agents, endocrine disrupting chemicals (EDCs), and other environmental toxicants. To determine whether extrinsic factors affect placental function, transcriptomics and other omics approaches have become more widely used. In casting a wide net with such approaches, they have provided mechanistic insights into placental physiological and pathological responses and how placental responses may impact the fetus, especially the developing brain through the placenta-brain axis. This review will discuss how such omics technologies have been utilized to understand effects of EDCs, including the widely prevalent plasticizers bisphenol A (BPA), bisphenol S (BPS), and phthalates, other environmental toxicants, pharmaceutical agents, maternal smoking, and air pollution on placental gene expression, DNA methylation, and metabolomic profiles. It is also increasingly becoming clear that miRNA (miR) are important epigenetic regulators of placental function. Thus, the evidence to date that xenobiotics affect placental miR expression patterns will also be explored. Such omics approaches with mouse and human placenta will assuredly provide key biomarkers that may be used as barometers of exposure and can be targeted by early mitigation approaches to prevent later diseases, in particular neurobehavioral disorders, originating due to placental dysfunction.