bluuebunny/crossref_metadata_2025 huggingface dataset:
Social work support and unmet social needs in life after stroke: a cross-sectional exploratory study
Authors: Lehnerer Sophie Mirabell , Hotter Benjamin , Padberg Inken , Knispel Petra , Remstedt Dike , Liebenau Andrea , Grittner Ulrike , Wellwood Ian , Meisel Andreas
Published: June 2019

Background:
Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to work, receive social benefits, participate in daily life activities, maintain contact with family and friends and to organize financial affairs. In our study we aimed to investigate if existing tools record social needs adequately. We analyzed the current provision of social support provided in long-term care after stroke and whether unmet social needs were associated with quality of life, caregiver burden, overall function and degree of disability.

Methods:
Our analysis is part of the Managing Aftercare of Stroke study (MAS-I), a cross-sectional exploratory study of patient needs 2-3 years after initial stroke. Assessment tools included the Nikolaus-score (social situation), the EuroQoL (quality of life), the German Burden Scale for Family Caregivers (caregiver burden), the modified Rankin Scale (disability / dependence), Stroke Impact Scale (function and degree of disability) and the Stroke Survivor Needs Questionnaire (unmet needs).

Results:
Overall 57 patients were included in MAS-I, with ten patients classified in urgent need of socio-economic support according to the Nikolaus-score. Patients with lower than normal Nikolaus-score had a higher degree of disability. Thirty percent of all patients had never received professional social support. Social worker contact happened mostly during the stay in acute hospital or rehabilitation institution. Only four patients (11%) reported long-term support after discharge. Apart from social worker contact during acute care, 43% of patients had unmet needs in the long-term aftercare. Forty percent of all patients included in MAS-I were recommended for social work intervention after an in-depth analysis of their situation. Finally, we saw that unmet social needs were associated with lower quality of life and higher caregiver burden.

Conclusions:
Our data suggest significant unmet needs in social care in long-term stroke patients. Screening tools for unmet social needs such as the Nikolaus-score do not holistically report patients’ needs.
Metagenomic analysis of bile salt biotransformation in the human gut microbiome
Authors: Das Promi , Marcišauskas Simonas , Ji Boyang , Nielsen Jens
Published: June 2019

Background: In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human physiology. Several 16S amplicon-based studies with inflammatory bowel disease (IBD) subjects were found to have an association with the level of fecal bile acids. However, a detailed investigation of all the bile salt biotransformation genes in the gut microbiome of healthy and IBD subjects has not been performed.

Results: Here, we report a comprehensive analysis of the bile salt biotransformation genes and their distribution at the phyla level. Based on the analysis of shotgun metagenomes, we found that the IBD subjects harbored a significantly lower abundance of these genes compared to the healthy controls. Majority of these genes originated from Firmicutes in comparison to other phyla. From metabolomics data, we found that the IBD subjects were measured with a significantly low level of secondary bile acids and high levels of primary bile acids compared to that of the healthy controls.

Conclusions: Our bioinformatics-driven approach of identifying bile salt biotransformation genes predicts the bile salt biotransformation potential in the gut microbiota of IBD subjects. The functional level of dysbiosis likely contributes to the variation in the bile acid pool. This study sets the stage to envisage potential solutions to modulate the gut microbiome with the objective to restore the bile acid pool in the gut.
Clinical observation of a patient with ankylosing spondylarthritis (Bechterew’s disease)
Authors: Tsurko V. V. , Egorov I. V. , Malysheva N. V.
Published: June 2019

Back pain (dorsopathy) is one of the common syndromes, which is specific to the whole group of diseases with similar clinical presentations. Ankylosing spondylarthritis (Bechterew’s disease) with a distinct clinical course evolving not only spinal and sacroiliac lesion, but also visceral changes is discussed using the example of a clinical case. The authors discuss Nimesulide, a drug from NSAID (non-steroidal anti-inflammatory drugs) group, in the treatment of inflammatory presentations of the disease and evaluate its efficacy.
Safety and tolerability of nsaids: focus on aceclofenac
Authors: Ushkalova E. A. , Zyryanov S. K. , Zalolochina K. E.
Published: June 2019

The article discusses the main problems of safety of non-steroidal anti-inflammatory agents (NSAIDs). The results of randomized clinical studies, pharmacoepidemiological studies and meta-analyses suggesting higher safety of aceclofenac compared to diclofenac and other widely used NSAIDs are presented. Special attention is paid to the new pharmaceutical form of aceclofenac – tablets with modified release, manufactured by Clanza technology, registered under the trade name Aceclagin. It is intended for a single injection per day, which allows to increase adherence to therapy.
Treatment of comorbid patients with chronic brain ischemia and vertebrogenic pain syndromes
Authors: Zakharov V. V. , Grinyuk V. V. , Vakhnina N. V. , Kalimeeva E. Yu.
Published: June 2019

Chronic brain ischemia and chronic pain both appear to be an extremely wide-spread disease. The reasons of widespread comorbidity of ischemic brain disease and chronic pain are common risk factors: old age, decrease of physical activity, syndrome of systemic inflammation and emotional disturbances. Treatment of patients with cerebrovascular diseases and chronic pain should influence common mechanisms of these disorders. Correction of microcirculatory disturbances pays particular important role, because this is the mechanism not only of chronic cerebral ischemia but compressive-ischemic radiculo- and neuropathy also.
Ocrelizumab therapy and long-term outcomes in multiple sclerosis: clinical and MRI-efficacyand safety profile
Authors: Klabukova D. L. , Davydovskaya M. V.
Published: June 2019

Ocrelizumab (Ocrevus®) is a humanized anti-CD20 monoclonal antibody approved for the treatment of adults with relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). The article presents data on the clinical and MRI efficacy and safety profile of ocrelizumab for the long-term use in patients with MS of various forms of the course. The authors performed the search, systematization and analysis of the pooled data of clinical studies and real clinical practice. Five-year follow-upof ocrelizumab therapy showed a compelling and clinical ly significant advantage in reducing the disease progression in patients with PPMS. After five-year ocrelizumab therapy in patients with PPMS, the study showed a reduction of the proportion of patients with disease progression and degree of brain atrophy, and more frequent achievement of the disease inactivity status (NEDA) as compared to patients with two- year delayed initiation of ocrelizumab therapy. The safety profile of the drug corresponds to the results obtained in the controlled periods of clinical trials.
Use of Artra and Artra MSM Forte in osteoarthritis of the large joints and lowback pain
Authors: Sharapova E. P. , Alekseeva L. I.
Published: June 2019

Knee and hip joint pain is the first and most common symptom that forces a patient to visit the doctor. Osteoarthritis (OA) treatment is aimed «primarily» at managing symptoms of the disease, i.e. reducing pain, improving the functional state of the joints, and finally at improving the patients’ quality of life. The Russian and international organizations have developed numerous guidelines for the treatment of OA, which include non-pharmacological and pharmacological methods, among which symptomatic slow-acting drugs are of special interest. These drugs are currently recommended to prescribe as the first-line drugs to treat OA. Analgesics and NSAIDs that rarely cause adverse effects, especially in older people and in patients with co-morbidities, who receive concomitant medications, are the most commonly prescribed medications for pain relief. This creates a problem when the drugs affect one another’s exposure and can limit the prescription of a range of drugs, which determines an increase in interest in other drugs called sustained-release symptomatic drugs, which are widely recognized in arthrology.

The article presents the results of studies of Artra and Artra MSM Forte in patients with hip and knee OA, which were conducted in Russia.
Trihalomethane precursor reactivity changes in drinking water treatment unit processes during a storm event
Authors: Neil Chelsea W. , Zhao Yingying , Zhao Amy , Neal Jill , Meyer Maria , Yang Y. Jeffrey
Published: June 2019

Source water quality can significantly impact the efficacy of water treatment unit processes and the formation of chlorinated and brominated trihalomethanes (THMs). Current water treatment plant performance models may not accurately capture how source water quality variations, such as organic matter variability, can impact treatment unit processes. To investigate these impacts, a field study was conducted wherein water samples were collected along the treatment train for 72 hours during a storm event. Systematic sampling and detailed analyses of water quality parameters, including non-purgeable organic carbon (NPOC), UV absorbance, and THM concentrations, as well as chlorine spiking experiments, reveal how the THM formation potential changes in response to treatment unit processes. Results show that the NPOC remaining after treatment has an increased reactivity towards forming THMs, and that brominated THMs form more readily than chlorinated counterparts in a competitive reaction. Thus both the reactivity and quantity of THM precursors must be considered to maintain compliance with drinking water standards, a finding that should be incorporated into the development of model-assisted treatment operation and optimization. Advanced granular activated carbon (GAC) treatment beyond conventional coagulation–flocculation–sedimentation processes may also be necessary to remove the surge loading of THM-formation precursors during a storm event.
Intermediary in a Collective Labor Dispute Resolution
Authors: Zaitseva L. , Gomes E. , Racheva S. , Cruz V.
Published: June 2019

Collective labor disputes based on the differences in economic interests between workers and employers can be effectively resolved exclusively through conciliation procedures. Contemporary alternative methods arose mostly due to the necessity to resolve collective labor disputes; mediation for this purpose is applied differently in various countries. National legislation equally provides various means for collective labor dispute resolutions and determines relevant intermediary procedures. An intermediation in a collective labor dispute resolution can be private and/or state-appointed and mandatory or alternative and remains a very perspective means of alternative dispute resolution. An analysis of different countries’ legislation distinguishes several common features of intermediation in collective labor disputes, concerning mainly the goals, objectives and principles. For bodies and persons conducting intermediation, the degree of compulsion in their decisions varies greatly from country to country. However, the obtained experience reveals common and distinctive procedural features and provides the possibility to classify existing approaches, having combined them into groups. The analysis also follows general development trends of collective labor dispute intermediation in different countries and identifies several shortcomings that are characteristic to different systems of intermediation legal regulation. Further research on the most effective ways of collective labor dispute conciliation is necessary for establishing new harmonious labor relations as the grounds for social progress.
Demand Guarantees in the People’s Republic of China and the Republic of South Africa
Authors: Hugo Ch.
Published: June 2019

Guarantees play an important role in large commercial contracts internationally. Guarantees can be either independent (demand) guarantees or accessory guarantees. The legal consequences of the two differ significantly and, therefore, it is important to differentiate clearly between the two. In the case of independent (demand) guarantees – the focus of this contribution – the guarantor’s liability is independent of the underlying performance it is guaranteeing, and is accordingly to be determined, in principle, with reference only to the terms of the guarantee. However, this is not an absolute principle. Jurisdictions throughout the world recognize exceptions to this principle, the most important and prevalent being fraud on the part of the beneficiary. A Judicial Interpretation by the Supreme People’s Court of the People’s Republic of China relating to independent guarantees came into operation in December 2016. Its rules depart in some important respects from the law of guarantees in South Africa, both in relation to the determination of the nature of the guarantee (as independent or accessory) and in relation to the exceptions to the principle of independence. This article explores these issues against the background of the law of contract of both countries.
Legal and Regulatory Framework of the Payment and E-Money Services in the BRICS Countries
Authors: Shamraev A.
Published: June 2019

This article focuses research on a comparative analysis of the legal and regulatory framework of the payment and e-money services in the BRICS countries. These services are the most receptive to innovation and considerably contribute to financial inclusion. The central banks of the BRICS countries play key roles in their national payment systems, and they each have different statutory authorities on regulation and supervision or oversight of payment services providers, payment schemes and payment systems. Nevertheless, there are a number of features common to all the BRICS countries and the research emphasizes and describes these features as well as distinguishes national particularities.
Transitional Justice in South Africa and Brazil: Introducing a Gendered Approach to Reconciliation
Authors: Nelaeva G. , Sidorova N.
Published: June 2019

The concept of transitional justice has been associated with the periods of political change when a country emerges from a war or turmoil and attempts to address the wrongdoings of the past. Among various instruments of transitional justice, truth commissions stand out as an example of a non-judicial form of addressing the crimes of the past. While their setup and operation can be criticized on different grounds, including excessive politization of hearings and the virtual impossibility of meaningfully assessing their impact, it has been widely acknowledged in the literature that the Truth and Reconciliation Commission in South Africa can be regarded as a success story due to its relatively strong mandate and widespread coverage and resonance it had in South African society. We would like to compare this commission from the 1990s with a more recent example, the Brazilian National Truth Commission, so as to be able to address the question of incorporation of gendered aspects in transitional justice (including examination of sexual violence cases, representation of women in truth-telling bodies, etc.), since gender often remains an overlooked and silenced aspect in such initiatives. Gendered narratives of transitional justice often do not fit into the wider narratives of post-war reconciliation. A more general question addressed in this research is whether the lack of formal procedure in truth commissions facilitates or hinders examination of sexual crimes in transitional settings.
Alpha-1 Antitrypsin Deficiency and Chronic Obstructive Pulmonary Disease: Between Overlaps, Phenotypes and Illnesses
Authors: Corlateanu Alexandru , Covantev Serghei , Caraivanova Irina , Bodrug Vlada , Botnaru Victor , Varon Joseph , Siafakas Nikolaos
Published: June 2019

Alpha-1 antitrypsin deficiency (AATD) or alpha-1 antitrypsin proteinase inhibitor (α1-Pi) deficiency, is a genetic disorder leading to a higher risk of pulmonary, hepatic and other organrelated diseases. The spectrum of diseases associated with AATD is large and includes pulmonary conditions (COPD, asthma, asthma-COPD overlap syndrome, bronchiectasis, etc.) as well as extrapulmonary (liver diseases, systemic vasculitis, rheumatoid arthritis, panniculitis, multiple sclerosis, peripheral neuropathy). We present a review of AATD focusing on its connection to other conditions.
Taxonomic and Functional Annotation of Termite Degraded Butea monosperma (Lam.) Kuntze (Flame of the Forest)
Authors: Kumar Ashwani , Vyas Preeti , Malla Muneer A. , Dubey Anamika
Published: June 2019

Background:

Butea monosperma is an economically and medicinally important plant that grows all over India, however, the plant is highly susceptible to termite attack. The present study unravelled the bacterial community composition and their functional attributions from the termite degraded Butea.

Methods:

Total genomic DNA from termite degraded Butea monosperma samples was extracted and subjected to sequencing on Illumina's Miseq. The raw and unassembled reads obtained from high-throughput sequencing were used for taxonomic and functional profiling using different online and stand-alone softwares. Moreover, to ascertain the effect of different geographical locations and environmental factors, comparative analysis was performed using four other publically available metagenomes.

Results:

The higher abundance of Actinobacteria (21.27%), Proteobacteria (14.18%), Firmicutes (10.46%), and Bacteroidetes (4.11%) was found at the phylum level. The genus level was dominated by Bacillus (4.33%), Gemmatimonas (3.13%), Mycobacterium (1.82%), Acidimicrobium (1.69%), Thermoleophilum (1.23%), Nocardioides (1.44%), Terrimonas and Acidithermus (1.09%) and Clostridium (1.05%). Functional annotation of the termite degraded B. monosperma metagenome revealed a high abundance of ammonia oxidizers, sulfate reducers, dehalogenators, nitrate reducers, sulfide oxidizers, xylan degraders, nitrogen fixers and chitin degraders.

Conclusion:

The present study highlights the significance of the inherent microbiome of the degraded Butea shaping the microbial communities for effective degradation of biomass and different environmental toxicants. The unknown bacterial communities present in the sample can serve as enzyme sources for lignocelluloses degradation for biofuel production.
Job Satisfaction as a Mediator for the Influence of Transformational Leadership and Organizational Culture on Organizational Citizenship Behavior
Authors: Aldrin Neil , Yunanto Kuncono Teguh
Published: June 2019

Background:

This study aims to explore the effect of transformational leadership and organizational culture on organizational citizenship behavior and see whether job satisfaction functions as a good mediator

Methods:

By using a quantitative approach, the data collection tool uses a psychological scale, the research respondents (N = 232) are employees and leaders of one company.

Results:

The results of the study show that job satisfaction functions as a mediator of the influence of transformational leadership and organizational culture on organizational citizenship behavior.

Conclusion:

By applying transformational leadership style accompanied by building a good organizational culture the organization has strong capital to foster employee organizational citizenship behaviour. This study also provides empirical evidence of the influence of these two variables on organizational citizenship behaviour through job satisfaction.
The Association Between Diabetes and Cognitive Function in Later Life
Authors: Momtaz Yadollah A. , Hamid Tengku A. , Bagat Mohamad F. , Hazrati Maryam
Published: June 2019

Introduction:

Although diabetes through several possible mechanisms such as increased
microvascular pathology and inefficiency of glucose utilization during cognitive tasks can be associated
with cognitive impairment, there is inconclusive evidence that shows elderly diabetic patients
under therapy have higher cognitive function compared to their non-diabetics counterparts.
The present study was conducted to elucidate the association between diabetes and cognitive function
in later life.

Methods:

Data for this study, consisting of 2202 older adults aged 60 years and above, were taken
from a population-based survey entitled “Identifying Psychosocial and Identifying Economic Risk
Factor of Cognitive Impairment among Elderly. Data analysis was conducted using the IBM SPSS
Version 23.0.

Results:

The mean of MMSE was found to be 22.67 (SD = 4.93). The overall prevalence of selfreported
diabetes was found to be 23.6% (CI95%: 21.8% - 25.4%). The result of independent t-test
showed diabetic subjects had a higher mean score of MMSE (M = 23.05, SD =4 .55) than their
counterparts without diabetes (M = 22.55, SD = 5.04) (t = -2.13 p<.05). The results of multiple linear
regression analysis showed that diabetes was not significantly associated with cognitive function,
after controlling the possible confounding factors.

Conclusions:

The findings from the current study revealed that diabetes is not associated with cognitive
decline. This study supports the findings that long-term treatment of diabetes may reduce the
risk of cognitive decline. This finding may provide new opportunities for the prevention and management
of cognitive decline.
The Edinburgh Postnatal Depression Scale: Model Comparison of Factor Structure and its Psychosocial Correlates Among Mothers at One Month After Childbirth in Japan
Authors: Hada Ayako , Kubota Chika , Imura Masumi , Takauma Fumie , Tada Katsuhiko , Kitamura Toshinori
Published: June 2019

Background:

The Edinburgh Postnatal Depression Scale (EPDS; Cox, Holden & Sagovsky, 1987) has been widely used as a screening instrument. It is also used as a measure of Postnatal Depression (PND) severity. Various EPDS factor structure models have been proposed in many studies without an unequivocal conclusion. We compared first-order, higher-order factor, and bifactor models of the EPDS, and examined possible predictors of subscales by Structural Equation Modelling (SEM).

Methods:

Data came from a follow-up study of 758 women after childbirth on two occasions (five days and one month postnatal). We used the EPDS together with items tapping Negative Life Events (NLEs) and coping styles and behaviours.

Results:

The bifactor model showed the best fit with data compared with all other models: CFI = 0.999, RMSEA = 0.14, and AIC = 79.637. A single general dimension alongside three distinct subfactors (anhedonia, anxiety, and dysphoria) was predicted differentially by various predictor variables.

Conclusion:

Our study expanded on a previous factor structural study of the EPDS and developed the hierarchical (bifactor) model. The model’s construct validity was confirmed by its meaningful associations with NLEs and coping styles and behaviours.
Design of Reversible Shift Register Using Reduced Number of Logic Gates
Authors: Maity Heranmoy , Banerjee Sudipta , Biswas Arindam , Pal Anita , Bhattacharjee Anup Kumar
Published: June 2019

Background:

Over the last few decades, reversible logic system/circuits have received considerable
attention in the diversified fields such as nanotechnology, quantum computing, cryptography,
optical computing and low power design of VLSI circuits due to their low power dissipation
characteristics.

Methods:

In this paper, we proposed the design of reversible shift register (SR) i.e. serial-in-serial out
(SISO), serial-in-parallel out (SIPO), parallel-in-serial out (PISO) and parallel-in-parallel out (PIPO)
SR using a reduced number of reversible logic gates and garbage output.

Results:

As compared to previously reported results, the improvement in our proposed model of SISO,
SIPO, PISO and PIPO was found to be 50 – 66.66 %, 42.85 – 66.66 %, 12.5 – 53.33 % and 50 –
66.66 % respectively, in terms of the number of reversible logic gates.
Amino Acid Profiles, Antimicrobial Activity and Anti-nutritional Contents of Two Wild Edible Plants (Sphenoclea zeylanica Gaertn. and Sphaerantus peguensis Kurz ex C.B. Clarke.)
Authors: Narzary Hwiyang , Basumatary Sanjay
Published: June 2019

Background:

The two wild plants viz. Sphenoclea zeylanica and Sphaerantus peguensis are seasonally consumed as vegetables by the Bodo people in Assam of North East India. Wild vegetables are considered as one of the cheapest sources for human nutrition that contains rich sources of numerous minerals and bioactive compounds which on consumption can contribute several health benefits against various diseases.

Objective:

The aim of the present study is to investigate amino acid profiles, antimicrobial property and anti-nutritional contents of the two wild edible plants.

Methods:

Amino acid profiles were determined by using ultra-performance liquid chromatography, antimicrobial activities of aqueous and methanol extracts of the plants were tested following the disc diffusion method against Bacillus cereus, Staphylococcus aureus, Proteus vulgaris and Escherichia coli, and anti-nutritional contents were evaluated based on the reported methods.

Results:

The total amino acid content found in S. zeylanica was 42.87 mg/g dry weight and it was found to be 32.65 mg/g dry weight in S. peguensis. The methanol extracts of the plants are exhibiting antibacterial activities against all the studied microorganisms. However, aqueous extracts showed no antibacterial activity against P. vulgaris and B. cereus. In this study, S. zeylanica species showed higher levels of anti-nutritional contents compared to S. peguensis.

Conclusion:

In the study, higher levels of essential amino acids were detected in S. zeylanica compared to S. peguensis. The methanol extracts of the plants showed more effective antimicrobial activities in comparison to the aqueous extracts and this may be due to the presence of antimicrobial compounds which are more readily soluble in methanol.
Self-medication of Ayurvedic Medicine Associated with Fatal Toxic Epidermal Necrolysis: A Case Report
Authors: Jangra Manjeet Singh , Chhabra Manik , Bhagavathula Akshaya Srikanth
Published: June 2019

Introduction:

Ayurveda is one of the most renowned traditional systems of medicine
and is widely practiced in India. Self-medication of these ayurvedic medicines (AM’s)
may elicit more or less similar type of adverse reactions as synthetic drugs.

Methods:

We present a case report on toxic epidermal necrolysis due to self-medication of
ayurvedic medicine.

Case Report:

The present case is of a patient who used Singhnad Guggulu for 20 days and
developed Steven-Johnson Syndrome (SJS) followed by toxic epidermal necrolysis (TEN).
The patient was treated with steroids and antihistamines. The patient recovered completely
following seven days of treatment and discharged.

Results:

After ruling out the provisional diagnosis, the patient was diagnosed with druginduced
SJS/TEN. The World Health Organization-Uppsala Monitoring Center (WHOUMC)
causality assessment scale was used by taking into consideration the temporal relationship
and other relevant parameters and adverse drug reaction (ADR) was found to be
‘certain’.

Conclusion:

To our knowledge, the present case study is the first report of SJS/TEN that
was caused by “Singhnad Guggulu” suggesting clinicians to be vigilant about the possibility
of SJS/TEN occurrences with AM. Also, consumers should be advised to use these drugs
only on the prescription of the institutionally qualified ayurvedic practitioners.
Using Patient Portals to Improve Patient Outcomes: Systematic Review (Preprint)
Authors: Han Hae-Ra , Gleason Kelly T , Sun Chun-An , Miller Hailey N , Kang Soo Jin , Chow Sotera , Anderson Rachel , Nagy Paul , Bauer Tom
Published: June 2019

BACKGROUND

With the advent of electronic health record (EHR) systems, there is increasing attention on the EHR system with regard to its use in facilitating patients to play active roles in their care via secure patient portals. However, there is no systematic review to comprehensively address patient portal interventions and patient outcomes.

OBJECTIVE

This study aimed to synthesize evidence with regard to the characteristics and psychobehavioral and clinical outcomes of patient portal interventions.

METHODS

In November 2018, we conducted searches in 3 electronic databases, including PubMed, EMBASE, and Cumulative Index to Nursing and Allied Health Literature, and a total of 24 articles met the eligibility criteria.

RESULTS

All but 3 studies were conducted in the United States. The types of study designs varied, and samples predominantly involved non-Hispanic white and highly educated patients with sizes ranging from 50 to 22,703. Most of the portal interventions used tailored alerts or educational resources tailored to the patient’s condition. Patient portal interventions lead to improvements in a wide range of psychobehavioral outcomes, such as health knowledge, self-efficacy, decision making, medication adherence, and preventive service use. Effects of patient portal interventions on clinical outcomes including blood pressure, glucose, cholesterol, and weight loss were mixed.

CONCLUSIONS

Patient portal interventions were overall effective in improving a few psychological outcomes, medication adherence, and preventive service use. There was insufficient evidence to support the use of patient portals to improve clinical outcomes. Understanding the role of patient portals as an effective intervention strategy is an essential step to encourage patients to be actively engaged in their health care.
Clinical Genomic Sequencing Reports in Electronic Health Record Systems Based on International Standards: Implementation Study (Preprint)
Authors: Ryu Borim , Shin Soo-Yong , Baek Rong-Min , Kim Jeong-Whun , Heo Eunyoung , Kang Inchul , Yang Joshua SungWoo , Yoo Sooyoung
Published: June 2019

BACKGROUND

To implement standardized machine-processable clinical sequencing reports in an electronic health record (EHR) system, the International Organization for Standardization Technical Specification (ISO/TS) 20428 international standard was proposed for a structured template. However, there are no standard implementation guidelines for data items from the proposed standard at the clinical site and no guidelines or references for implementing gene sequencing data results for clinical use. This is a significant challenge for implementation and application of these standards at individual sites.

OBJECTIVE

This study examines the field utilization of genetic test reports by designing the Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) for genomic data elements based on the ISO/TS 20428 standard published as the standard for genomic test reports. The goal of this pilot is to facilitate the reporting and viewing of genomic data for clinical applications. FHIR Genomics resources predominantly focus on transmitting or representing sequencing data, which is of less clinical value.

METHODS

In this study, we describe the practical implementation of ISO/TS 20428 using HL7 FHIR Genomics implementation guidance to efficiently deliver the required genomic sequencing results to clinicians through an EHR system.

RESULTS

We successfully administered a structured genomic sequencing report in a tertiary hospital in Korea based on international standards. In total, 90 FHIR resources were used. Among 41 resources for the required fields, 26 were reused and 15 were extended. For the optional fields, 28 were reused and 21 were extended.

CONCLUSIONS

To share and apply genomic sequencing data in both clinical practice and translational research, it is essential to identify the applicability of the standard-based information system in a practical setting. This prototyping work shows that reporting data from clinical genomics sequencing can be effectively implemented into an EHR system using the existing ISO/TS 20428 standard and FHIR resources.
GERAKAN DAKWAH SULTAN AGUNG (Arti Penting Perubahan Gelar Sultan Agung Terhadap Gerakan Dakwah di Jawa Pada Tahun 1613 M - 1645 M)
Authors: Hariyanto Hariyanto
Published: June 2019

The peak of the glory of the Mataram kingdom occurred during the reign of Sultan Agung. He managed to perform da'wah movement to master Central Java, East Java and some areas in West Java. Many strategies of da'wah movement conducted by Sultan Agung. However, the change and the addition of the title by Sultan Agung is one thing that distinguishes the previous Mataram kings.

Sultan Agung recorded the changes and the addition of his title ranging from "Panembahan" to "Susuhunan" or "Sunan", to "Sultan" Degree "Susuhunan" or "Sunan" commonly used by the guardian gives charisma (authority) to the king. The title is used karen areas that have mastered the territory of the great Muslim Guardians. The title of "Sultan" which bears Sultan Agung further strengthens himself as a leader as well as a figure of Religion, who has responsibility towards his people and its creator .

Complexity of the title that carried the Sultan Agung able to raise its degree and bring social effects for the movement of his da'wah. Areas that did not initially recognize themselves as kings, managed to recognize themselves as kings and submit and obey the king's policies.

The complete title of Sultan Agung known as "Sultan Agung Hanyakrakusuma Senapati Ing Alaga Sayyidin Panatagama Khalifatullah" has the meaning that the third Mataram King is a leader who gets the mandate from Allah to organize the life of his people.

Keywords: Title, Sultan Agung, Movement of Da'wah
Editorial
Authors: Costa Luís Artur , Fonseca Tania Mara Galli
Published: June 2019

A revista Informática na Educação: teoria e prática busca estudar as relações instituintes estabelecidas
pelos objetos técnicos em nossa sociedade sem reduzi-los a uma mera ferramenta voltada
a um fim específico. A tecnologia adentra, aqui, o âmbito das relações sociais, inserindo-se nos
processos de subjetivação assim como em outros elementos da nossa cultura. Não pretendemos
com isso negar o caráter também instrumental da tecnologia, mas sim ampliar a complexidade do
escopo do seu estudo respeitando a heterogeneidade inerente à questão: da produção de objetos
técnicos ao estudo das redes sócio-técnicas. Nesse número, nos propomos a problematizar os
agenciamentos híbridos entre três fluxos na construção de um dispositivo de pesquisa e produção
das subjetividades no contemporâneo: a imagem, a tecnologia e a educação. Esses se unem em
uma heterogênese que cria novas tendências transformadoras no campo da pesquisa, da arte e
da educação.
Modelagem Probabilística de Aspectos Afetivos do Aluno em um Jogo Educacional Colaborativo
Authors: Pontarolo Edilson
Published: June 2019

Este trabalho apresenta o processo de construção de um modelo de inferência de emoções
que um aluno sente em relação a outros alunos durante interação síncrona em um contexto
de jogo colaborativo de aprendizagem. A inferência de emoções está psicologicamente fundamentada
na abordagem da avaliação cognitiva e foram investigadas relações entre objetivos e
normas comportamentais do aluno e aspectos de sua personalidade. Especificamente, foram
empregados o modelo OCC de emoções e o modelo Big-Five (Cinco Grandes Fatores) de traços
de personalidade para a fundamentação teórica da modelagem. O modelo afetivo representa
a vergonha e orgulho apresentados pelo aluno em resposta à avaliação cognitiva de suas próprias
ações; e a reprovação e admiração apresentadas pelo aluno em resposta a ações de seu
parceiro de jogo, a partir da avaliação do comportamento observável dos parceiros representado
por suas interações no jogo colaborativo, em relação a normas comportamentais do aluno.
A fim de suportar a incerteza presente na informação afetiva e cognitiva do aluno, adotou-se
uma representação deste conhecimento através de Rede Bayesiana. Um refinamento qualitativo
parcial e a respectiva parametrização quantitativa do modelo probabilístico foram efetuados
a partir da análise de uma base de casos obtida através da condução de experimentos. A fim
de prover um ambiente experimental, foi concebido e prototipado um jogo colaborativo no qual
dois indivíduos conjugam esforços a fim de resolver problemas lógicos comuns à dupla, através
de ações coordenadas, negociação simples e comunicação estruturada, em competição com
outras duplas.
Escritura na convergência de mídias
Authors: Demoly Karla Rosane Do Amaral
Published: June 2019

Esta tese é o resultado de uma análise sobre como um grupo de professoras em condições
perceptivas distintas escreve, quando se envolvem em uma experiência de escritura na convergência
de mídias. Trata-se de um estudo de natureza qualitativa que busca produzir uma análise
exploratória embasado principalmente nas Teorias da Biologia do Conhecer de Humberto
Maturana e na Teoria da enação de Francisco Varela, no que se referem ao modo de observar
e explicar um fenômeno a partir de uma experiência de escritura. A recursividade constitutiva
entre escrita e tecnologia é descrita por vários autores, demonstrando que as tecnologias
se transformam em ferramentas que modulam os modos de escrever. Situamos o trabalho no
campo da Antropologia da Escritura, ao mantermos um diálogo entre alguns de seus autores,
dentre os quais destacamos Jack Goody, Jacques Derrida, Roger Chartier e Béatrice Fraenkel.
A discussão sobre os modos de viver-conhecer no encontro com diferenças perceptivas visuais
e auditivas está embasada principalmente nas obras de Bernard Mottez, Brigitte Garcia, Yves
Delaporte e Zina Weygand. O principal foco da investigação foi acompanhar as modalidades de
escritura que as professoras – ouvintes e videntes, no encontro com uma professora cega e
uma professora surda – realizaram ao se propor a produzir um hiperdocumento coletivo. Para
análise da experiência, foi produzido um mapeamento da rede de escrituras tecida pelas professoras
em fóruns e salas de bate-papo em ambiente virtual. Os principais marcadores dessa
análise qualitativa e exploratória foram as escritas recorrentes e, principalmente, as questões
que as professoras formulavam a si e ao grupo na atividade de escrita ou de comentar sobre a
escrita feita. Uma diversidade de fonte de informações compõe este mapeamento e subsidiou
a análise: filmagens de oficinas organizadas durante a experiência de criação de uma escritura
digital, conversações escritas em fóruns e salas de bate-papo na Internet, recortes de diferentes
versões da produção de escritas para o hiperdocumento e anotações de campo. As práticas
de composição escrita na Internet provocam mudanças nas coordenações de ações, permitindo
o encontro entre pessoas que antes não poderiam produzir algo juntas. Estas mudanças nas
coordenações de ações, ao envolver um trabalho de manipulação e edição de diferentes mídias
- imagens, sons, textos e a Língua de Sinais – faz com que surja uma nova experiência de
escritura, implicando em mudanças cognitivas, afetivas e estéticas. Atos de escritura coletiva
e digital podem produzir uma convergência interativa na qual existem grandes possibilidades
de interlocução entre pessoas com diferentes condições perceptivas, pois mudam os modos
sensório-motores de acoplamento com a escrita e as coordenações de ações na rede de conversações
escritas tecidas pelas professoras.
Encapsulamento e utilização de objetos de aprendizagem abertos SCORM para ensejar a avaliação formativa
Authors: Dutra Renato Luis De Souza
Published: June 2019

A avaliação formativa, apesar de ter sido inicialmente pensada por Scriven há mais de 30 anos,
e ser discutida por diversos autores nas últimas décadas, ainda é pouco utilizada, tanto nos cursos
presenciais como a distância. Somente nos últimos anos, com a adoção de ciclos de aprendizagem,
a preocupação maior com o processo de ensino-aprendizagem e com o crescimento dos cursos
a distância, essa abordagem de avaliação começou a ganhar mais importância. Na Educação a
Distância (EAD), a avaliação formativa tem se mostrado uma excelente alternativa, por propiciar
aos professores um acompanhamento mais próximo e mais individualizado de seus alunos e por
permitir que professores e alunos regulem o processo de ensino-aprendizagem. Independente do
processo avaliativo, o desenvolvimento de conteúdos digitais educacionais na forma de objetos de
aprendizagem tem sido uma solução crescente na EAD. Para tanto, modelos de portabilidade e
interoperabilidade, como o SCORM, proporcionaram uma grande evolução em termos de reusabi-
lidade, portabilidade e interoperabilidade e, aliados à utilização de licenças que permitam a livre
utilização, distribuição e modificação, possibilitam ao ambiente acadêmico facilmente intercambiar
objetos de aprendizagem, independente de plataforma de hardware e software. Dessa forma, o de-
senvolvimento de objetos de aprendizagem, largamente utilizados na EAD, deveria levar em con-
sideração o processo de avaliação formativa. Com base nessas constatações, a presente pesquisa
buscou identificar quais critérios deveriam ser levados em consideração para o encapsulamento e
a utilização de Objetos de Aprendizagem Abertos SCORM em Ambientes Virtuais de Aprendizagem,
a fim de apoiar o processo de avaliação formativa.
A interdisciplinaridade na ação de projetar ambientes virtuais de aprendizagem: o caso NUTED/UFRGS
Authors: Leite Silvia Porto Meirelles
Published: June 2019

A presente tese investiga o fenômeno projetos interdisciplinares de Ambientes Virtuais de
Aprendizagem (AVA’s), destacando sua recorrência em diferentes contextos. Para tanto, realiza
um estudo de caso sobre o engendramento da interdisciplinaridade na ação de projetar AVA’s no
Núcleo de Tecnologia Digital Aplicada à Educação (NUTED) da Universidade Federal do Rio Grande
do Sul (UFRGS), no qual são desenvolvidos os projetos ROODA, PLANETA ROODA e ETC. Entende-
se que o debate a cerca desse tema contribui para uma reflexão sobre o desenvolvimento científico
e tecnológico em informática na educação, bem como sua natureza interdisciplinar. Tal abordagem
agrega uma perspectiva teórico-metodológica piagetiana, a qual orientou os questionamentos, a
elocução conceitual e a coleta e as análises dos dados. Com isso, enfoca-se a construção de co-
nhecimento a partir da interação entre sujeito (projetista) e objeto de estudo (AVA), entre sujeitos
(projetistas) e entre os conhecimentos disciplinares, elucidando a interdependência entre as re-
lações individuais, interindividuais e interdisciplinares. Também é abordado o jogo entre forma e
conteúdo que caracteriza a ação de projetar e a interdisciplinaridade, de modo que os observáveis
apontados e as coordenações realizadas pelos projetistas se configuram como os observáveis des-
sa tese. As três unidades de análise observadas nas fontes de evidência desse caso são: sistema
de significações, valores coletivos e regras formais. A partir das relações entre as evidências co-
letadas e os pressupostos teórico-metodológicos, realizam-se coordenações que convergem para
as categorias de análise, que são: relações interdisciplinares, criação de novidades e cooperação
entre os projetistas.
Intencionalidade e agenciamento na previsão do potencial de aprendizagem em uma atividade computacional
Authors: Stager Gary S.
Published: June 2019

É o computador que programa a criança ou é a crian-
ça que programa o computador? A quem serve o quadro branco interativo? Quais são os objetivos que justificam o investimento de uma escola na tecnologia digital? A intenção do uso da tecnologia e a preferência em vista do agenciamento na transação da aprendizagem têm muito a ver com os benefícios para o aluno. É impossível discutir os benefícios potenciais da aprendizagem no uso do computador sem uma linguagem precisa para descrever o valor que acrescenta o computador. Muitos educadores que utilizam computadores e seus críticos elevam a importância do uso de computadores a um patamar superficial, ao mesmo tempo em que marginalizam seus usos mais elevados. Atualmente, tem sido concedida equivalência a todos os modos de atividades baseadas no computador, faltando uma medida adequada para avaliar seu valor. Quando combinados com o uso liberal e muitas vezes impreciso dos termos, como construtivista, ficamos com uma cultura do relativismo intelectual, onde a voz mais alta define a ordem do dia. Este trabalho tenta definir o continuum em que se situa o uso de computadores para reforçar a prática tradicional e as idéias em potencial. Paradigmas existentes para avaliação de tecnologia educacional confundem ensino e aprendizagem ao fazer pouco caso do valor de uma atividade. O
currículo e a fluência do professor são confundidos com o aprendizado do aluno. Estes esquemas podem descrever a prática de ensino, mas oferecem pouco benefício previsto aos alunos. Este trabalho propõe a criação de um continuum que procura dissipar o distanciamento entre as rotinas da educação tradicional, eventualmente reforçadas pelo uso do computador, e o tipo de construção de idéia poderosa, que só é possível acontecer com o uso intencional do computador, visando beneficiar, sobretudo, ao aluno. Os fatores de articulação, intencionalidade e agenciamento não só influencia o que é aprendido, como também tem implicações em orçamentos, desenvolvimento profissional, currículo e investimento em tecnologia.
Por um modelo de processo de instrução/aprendizagem para facilitar o ciclo de design instrucional
Authors: Hayashi Yusuke , Isotani Seiji , Bourdeau Jacqueline , Mizoguchi Riichiro
Published: June 2019

Muitos modelos de design instrucional foram pro-
postos e seus benefícios são evidentes. No entanto, há falta
de uma notação comum e formal para descrever o produto
da concepção. Isso faz com que haja dificuldade na avalia-
ção do produto (o curso) em desenvolvimento. Para elimi-
nar essa dificuldade, precisamos de uma estrutura formal
que tenha semântica suficiente para manter a consistência
do produto. Assim, este trabalho tem por objetivo propor
um padrão de modelo unificado para o ensino e aprendi-
zagem baseado em ontologias, que tenha potencial para
apoiar algumas fases do ciclo de design instrucional. Além
disso, damos um exemplo de como a instrução um a um e
a aprendizagem colaborativa são modeladas com base no
padrão proposto.
Orientações de design para Agentes Pedagógicos Animados
Authors: Moraes Márcia Cristina , Silveira Milene Selbach
Published: June 2019

A área de agentes animados pedagógicos está
relacionada ao desenvolvimento de aplicações que visam
melhorar o processo de interação humano-computador
(por humanos queremos dizer estudantes e professores)
utilizando software de agentes representados por caracte-
res ou figuras humanas. A fim de ajudar os pesquisado-
res a projetar agentes pedagógicos que possam melhorar
a usabilidade do agente humano, este trabalho vai discutir
as diretrizes básicas para o design de Agentes Animados
Pedagógicos, com base nos conceitos fornecidos pela In-
formática na Educação, Inteligência Artificial e Interação
Humano-Computador.