bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of the causative mutation in the ITGB2 gene in a LAD1 patient by whole exome sequencing
Authors: Kim Lien Nguyen Thi , Van Anh Nguyen Thi , Van Tung Nguyen , Anh Linh Duong , Phuong Mai Nguyen Thi , Huy Hoang Nguyen
Published: August 2022

Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease is determined to be the mutations in the ITGB2 gene that codes for CD18, the beta chain of beta-2 integrins, leads to decreased expression or functioning of CD18. This deficiency leads to severe impairment of leukocyte adhesion to the vascular wall and leukocyte migration to sites of infection and inflammation. LAD1 has also been associated with inhibition of interleukin-23 and interleukin-17 resulting in a hyperinflammatory and chronic inflammation. Patients with LAD1 typically present in early infancy with recurrent, life threatening infections that are frequently fatal before 2 years of age  without hematopoietic stem cell transplant (HSCT). However, LAD1 is difficult to diagnose and many LAD1 patients die at a young age despite intensive antibiotic therapy. Accurate diagnosis requires detailed clinical information (delayed umbilical cord loss, severe periodontitis, delayed wound healing and sores, skin abscesses, and recurrent infection), and confirmation the absence of integrins by flow cytometric analysis. A better understanding of the molecular characteristics of this disease is needed to raise awareness and definitive diagnosis infants with LAD1. To definitive diagnosis, whole exome sequencing and Sanger sequencing were performed in an eighteen-month-old boy with severe leukocytosis, recurrent infections, delayed wound healing, and hepatosplenomegaly associated with an acquired cytomegalovirus infection. Two variants: One previously reported mutation (c.533C>T, p.Pro178Leu) and one novel variant (c.59-1G>A), in the ITGB2 gene were detected. These results can be used for definitive genetic diagnosis, genetic counseling, as well as a prenatal diagnosis in LAD1 patients.
Insight into Paphiopedilum x Dalatense Aver. (Orchidaceae) origin based on morphological and molecular markers
Authors: Thai Vinh Tran , Nie Bing H’ Yon , Kim Cong Vu , Tham Dang Thi , Phuong Linh Ngo , Ngoc Trieu Le , Duy Nong Van
Published: August 2022

Paphiopedilum callosum, Paphiopedilum villosum and Paphiopedilum ´ dalatense are endangered species and are currently listed as Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES, 2019) Appendix I species. Thus, the international trade for these naturally occurring species is forbidden. However, the in vitro propagated materials and their inter-species hybrids forced by breeders can be traded for commercial purposes. P. ´ dalatense is an endemic slipper orchid species of Vietnam with high aesthetic value. Currently, the natural reserves of this species have been greatly reduced by overexploitation. In this study, P. ´ dalatense was demonstrated to be the reversible hybrid species between P. callosum and P. villosum based on both morphological and molecular markers. P. ´ dalatense possesses intermediate morphological characteristics between P. callosum and P. villosum which could be recorded in leaf, in flower and its components such as lip, petal, and dorsal sepal. There were 23 sites in ITS1-5.8S rRNA-ITS2 region sequence of P. ´ dalatense which possess the nucleotide characteristic of both P. callosum and P. villosum. There were two out of three P. ´ dalatense investigated samples possessed partial matK gene which was identical to the corresponding sequence in P. villosum and the last sample possessed identical partial matK gene to P. callosum. Proving P. ´ dalatense to be the reversible hybrid species between P. callosum and P. villosum is the essentially scientific base for commercial breeding of P. ´ dalatense by artificial hybridization which contributes to avoid overexploiting the natural P. ´ dalatense resources.
Total phenolic, flavonoid contents and antioxidant activity of tamarind seed and pulp extracts
Authors: Phuong Ha Le , Van Ngoc Nguyen , Trang Huyen Nguyen Thi , Thu Hang Le Thi , Kieu Oanh Nguyen Thi , Tuyet Tran Thi , Mai Phuong Nguyen Thi , Minh Hong Nguyen Thi
Published: August 2022

Tamarind (Tamarindus indica) has long been known for its high nutrition content and pharmacological potential. However, there is lack of studies on the content of antioxidants, phenolic and flavonoid contents of tamarind seed grown in Vietnam. Thus, the aim of this study was to compare the seeds and pulps of Tamarindus indica from three different areas across Vietnam including Son La, Hai Phong and Sai Gon with regard to the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of their water and methanol extracts, as well as their cytotoxicity on a normal BKH-21cells. TPC and TFC were evaluated by the Folin–Ciocalteu reagent and aluminum chloride, respectively. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays were used to investigate antioxidant capacity. The safety of T. indica extracts was assessed by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Our results showed that the methanolic extracts yielded higher TPC (742.919 ± 50.360 mg GAE/g extract), TFC (68.492 ± 0.023 mg QE/g extract) and possessed stronger free radical scavenging activity (IC50 of 52.5 µg/mL) compared to that of water extracts. T. indica seeds from all three regions possessed higher TPC, TFC and antioxidant activity than those of pulps. Regarding the safety, in vitro analysis showed that tamarind seed and pulp extracts only became toxic to BHK-21 cell line at a very high concentration with IC50 values range from 143.77 µg/mL to 620.35 µg/mL. This study revealed that T. indica seeds and pulps can serve as functional food as well as potential antioxidants in pharmaceutical products.
Assessment of the genetic changes of the attenuated Hanvet1.vn strain compared with original virulent 02HY strain of the porcine reproductive and respiratory syndrome virus
Authors: Thi Nga Nguyen , Thu Ha Thi , Hoa Nguyen Thi , Hien Vu Thi , Thu Trang Nguyen , Thanh Ba Nguyen , Van Khanh Tran , Huu Vu Nguyen , Van Quyen Dong , Long Thanh To , Duy Khang Dinh
Published: August 2022

The attenuated porcine reproductive and respiratory syndrome virus (PRRSV) strain Hanvet1.vn was developed by Hanvet Pharmaceutical Co., Ltd. by inoculating the virulent strain 02HYon Marc-145 cells for 80 generations and used to produce PRRS vaccine. In this study, we published the results of sequencing, analyzing and comparing the genome of the attenuated PRRSV strain Hanvet1.vn compared with the original pathogenic strain 02HY. The genomes of strains Hanvet1.vn and 02HY have 8 reading frames, coding for 8 non-structural and structural proteins: NSP1a, NSP1b, GP2, GP3, GP4, GP5, MP, NP. After sequencing and translating into proteins, the gene sequence of each open reading frame (ORF) of strain Hanvet1.vn was compared with the sequence of pathogenic strain 02HY to find nucleotide and amino acid changes. The results showed that the Hanvet1.vn pathogenic strain genome (Genbank Accession KU842720) when compared with the pathogenic strain 02HY genome (Submission2490633) had89 nucleotide mutations that changed 51 amino acids in 7 ORFs and 7 proteins, respectively. Particularly, ORF6 encoding for the M protein is completely unchanged. The size of each reading frame is also exactly the same. It showed that there were no insertion and deletion (Indel) mutations in the ORFs of the attenuated strain after 80 generations of inoculation. There was a change in the genome that made the strain Hanvet1.vn become attenuated, but the gene encoding for the GP5 protein that induces the production of neutralizing antibodies only changed two nucleotides at position 471 (A->G), causing the TCA codon to turn into a TCG codon. This is a silent mutation and both codons code for the amino acid Serine (S). The second mutation at position 587 (A->T) causes Glutamine (Q) to transform into Leucine (L). However, this modification does not belong to the GP5 antigenic epitopes. In clonclusion, after 80 passages, despite changes occurred in genes of Hanvet1.vn strain for becoming an attenuated strain, the GP5 protein of the attenuated strain did not change its antigenic amino acids.
EN PRENSA In vitro evaluation of the antimicrobial activity of two types of oregano (Lippia berlandieri) essential oils against bacteria from shrimp ponds EN PRENSA
Authors: Gracia-Valenzuela Martina Hilda , Arias-Moscoso Joe Luis , Ochoa-Meza Alba Rocio , Escobedo-Bonilla Cesar Marcial
Published: August 2022

La actividad antimicrobiana de aceites esenciales (AEO) del orégano mexicano (Lippia berlandieri) fue evaluada contra bacterias que viven en estanques de camarón. Un AEO tuvo mayor contenido de timol y el otro tuvo mayor contenido de carvacrol, ambos compuestos tienen propiedades antimicrobianas. Aislados bacterianos (n = 19) fueron recolectados en granjas camaronícolas, de hepatopáncreas de camarón, agua de estanque y/o sedimentos. El género Pseudomonas fue el más frecuente ya que se encontró en cuatro de 13 granjas, y fue aislada principalmente de hepatopáncreas. Todos los aislados se usaron para evaluar el efecto antimicrobiano de cinco antibióticos y los dos AEOs mediante pruebas de zona de inhibición. La actividad antimicrobiana de los dos AEOs fue estadísticamente significativa contra siete especies bacterianas, comparada con los otros antibióticos (P < 0.007143). Las especies bacterianas sensibles al AEO rico en timol fueron Serratia marcescens, Proteus vulgaris y Salmonella spp., mientras que Enterobacter cloacae, Serratia marcescens y Salmonella typhi fueron susceptibles al AEO rico en carvacrol. El AEO rico en timol tuvo un efecto antibacterial significativamente mayor que la oxitetraciclina, magnamicina, aviflox y enrofloxacina, mientras que el AEO rico en carvacrol superó a la oxitetraciclina y magnamicina. En conclusión, los dos AEOs evaluados tuvieron mayores propiedades antibacteriales que la de varios de los antibióticos usados en este estudio.
InSAR and numerical modelling for tailings dam monitoring – the Cadia failure case study
Authors: Bayaraa Maral , Sheil Brian , Rossi Cristian
Published: August 2022

In this paper, ground deformation measurements from synthetic aperture radar interferometry (InSAR) and ground-based prism monitoring are compared to finite-element (FE) simulation results for a recent tailings dam collapse. The InSAR monitoring demonstrated the complex spatial and temporal variability of the tailings dam deformation that is not captured in traditional, point-based monitoring approaches. Potentially anomalous deformation behaviour could have been detected from InSAR 1 year preceding the dam failure. A two-dimensional coupled-consolidation analysis was used to predict the dam behaviour during construction stages. The FE modelling results were in broad agreement with the deformation measurement sources, both in terms of magnitude and trends preceding failure. The results, however, deviate significantly immediately before failure, following the construction of the buttresses. Moreover, the FE modelling is sensitive to parameter uncertainties, such as spatial variability of foundation soil properties. The FE results revealed that deformation in both the upstream and downstream parts of the dam are sensitive to changing foundation properties. However, this impact is potentially much more significant on the downstream compared to the upstream parts of the dam, which are dominated by the behaviour of the tailings. This study highlights the efficacy and complementarity of geotechnical and remote sensing techniques for the monitoring of tailings dams.
Os sons da quarentena: música, memória e o fenômeno das lives na pandemia da Covid-19
Authors: Lessa Leonardo Alexsander , Bressan Júnior Mario Abel
Published: August 2022

Em 2020, um novo tipo de Coronavírus colocou o mundo em estado de pandemia. O objetivo deste artigo é investigar o consumo de músicas nostálgicas nesse período diante das teorias da memória coletiva e teleafetiva. Para isso, realizamos Análise de Conteúdo de comentários publicados em uma transmissão online que homenageou a banda Mamonas Assassinas. Os resultados demonstram benefícios afetivos e emocionais ocasionados por meio das músicas e da memória, especialmente em contextos de ansiedade.
Os impactos da Covid-19 sobre o Turismo e a Cultura na Bahia, Ceará e Pernambuco: Estratégias para sustentabilidade e fortalecimento da marca lugar
Authors: Miranda Mariana Pinto , Sampaio Adriano Oliveira , Falcão Janine , Soares Rodrigo Maurício Freire
Published: August 2022

Este trabalho apresenta o relatório parcial da pesquisa Turismo Sustentável, uma das respostas à crise da Covid-19, realizada pela Embaixada da França no Brasil, o Consulado Geral da França no Nordeste, as Alianças Francesas (Bahia, Ceará e Pernambuco) e o Grupo de Pesquisa Logos Comunicação Estratégica, Marca e Culturada UFBA. Foram entrevistados 212 profissionais da Cultura e Turismo da Bahia, Ceará e Pernambuco com a finalidade de mapear o cenário atual e buscar perspectivas de enfrentamento. Na etapa futura, serão apresentadas projeções e medidas de enfrentamento à crise.
Conversações online e videoconferência com amigos e familiares como forma de suportar o isolamento durante a pandemia de Covid-19
Authors: Primo Alê
Published: August 2022

Este trabalho busca discutir, baseado em dados de uma pesquisa quantitativa (N=725), como as mídias sociais e os serviços de videoconferência foram utilizados para a busca de informações e para a manutenção dos relacionamentos com amigos e familiares durante o período de isolamento social em virtude da pandemia do COVID-19. Além disso, este artigo também reflete sobre o impacto emocional da falta de convívio presencial, do tempo ampliado de conexão à internet e do bem-estar durante a pandemia.
Analysis of the Effect of Graphene Sheet Coating on Shielding Effectiveness for Shielding Enclosures with Different Aperture Shapes
Authors: GÜLER Sunay , YENİKAYA Sibel
Published: August 2022

Electromagnetic compatibility (EMC) has become much more important especially over the last decade due to incorporating advanced driver assistance and electric propulsion systems into conventional vehicle architecture. Electromagnetic shielding is a conductive barrier used for protecting electronic circuits against external electromagnetic interference (EMI). Shielding effectiveness (SE) is a measure of shielding performance against an interfering electromagnetic source. Design limitations inside electric vehicles (EV) forces to investigate on increasing SE without changing the shielding enclosure dimensions. Graphene is widely used in many studies due to its good conductivity and strong structure. In this study, a numerical model for a shielding enclosure in which inner surfaces are coated with graphene sheets, is designed. The effect of different aperture shapes on SE is analyzed according to coating different inner surfaces of the enclosure with graphene sheets.
Simulation Supported Facility Design: Application in a Manufacturing System
Authors: CANBULUT Gülçin , VURAL Nisa Bahar , KAVAK Gaye
Published: August 2022

System simulation is a very useful method when it is not possible to make changes on the reel system or it is very costly. Simulation has been applied by researchers in many fields and successful results have been obtained. In this study, the simulation method will be used to solve the problems arising from the facility layout in a manufacturing enterprise.Lack of a systematic layout study in a manufacturing enterprise; it makes it inevitable to encounter situations such as machine and job waiting, overloading of machinery and workers in the workflow processes of the enterprise. Insufficient layout causes unnecessary transportation costs between departments/machines. If business facility layout is systematically arranged; with the reduction of transportation costs, production costs can be reduced, and the competitiveness of the company can be increased.In this study, it is aimed to eliminate the cost increases caused by settlement in a manufacturing enterprise. The production system is first examined by examining the facility layout; systematic suggestions for improvement will be made. Due to the difficulty of implementing it on the real system; the comparison of the current situation and the proposed situation can be made by using simulation method. Also, through the simulation of the existing system, resources that create a bottleneck in the system are determined. Suggestions will be made for resource planning with different scenarios.
STRATEGI PROMOSI PENERIMAAN MAHASISWA BARU UNTUK PTS (Tinjauan atas kegiatan Promosi PTS di Jawa Barat Tahun 2010)
Authors: Sopandi Encep
Published: August 2022

Strategi Penerimaan Mahasiswa Baru PTS dimulai dengan konsep mengenai bagaimanamenggunakan sumber daya yang dimiliki oleh lembaga secara lebih efektif dalam suatu lingkunganyang sedang berubah. Pembuat strategi harus siap menyeleksi sasarannya sesuai dengan arusutama perubahan, sehingga perlu untuk menganalisis implikasi perubahan-perubahan sosialdalam penentuan suatu strategi. Analisis lingkungan untuk memperhatikan kecenderungankesempatan dan ancaman yang dihadapi. Strategi PMB PTS didisain untuk memastikan bahwatujuan manajemen pendidikan dapat dicapai melalui tindakan yang tepat, sehingga sukses ataugagalnya pencapaian tujuan bergantung pada strategi yang digunakannya. Perencanaan strategidan pelaksanaan strategi perlu dikombinasikan untuk mencapai sukses.Kegagalan suatu strategi PMB PTS kemungkinan disebabkan tujuan tidak realistis,kesalahan strategi yang dipakai, dan strategi yang dipakai benar tetapi pelaksanaan tidak berhasilmencapainya. Walaupun tecapainya tujuan belum membuktikan kebenaran strategi karenakesulitan untuk mengukur unsur-unsur tertentu dari strategi yang sinergetik.Kegiatan promosi merupakan kegiatan membangun komunikasi antara sekolah dengancalon mahasiswa atau keluarganya dengan tujuan untuk mempengaruhi keputusan merekadalam memilih suatu sekolah. Dengan demikian, dalam kegiatan promosi terdapat unsur apayang diinformasikan, media komunikasi yang digunakan, dan kepada siapa informasi tersebutdisampaikan. Di samping itu, terdapat pula kegiatan promosi untuk meningkatkan mahasiswabaru yang terdaftar melalui pendekatan sales promotion, seperti dengan penetapan biaya yangdibebankan kepada mahasiswa lebih rendah dari PTS lain. Kegiatan ini dimaksudkan untukmeng-counter PTS lain yang menjadi «saingan».PTS-PTS besar dan kuat di Jawa Barat tahun 2010 umumnya telah melakukan kegiatanpromosi dengan memperhatikan aspek strategis, yaitu menganilisis situasi intern dan ekstern,penetapan tujuan, pemilihan dan penetapan strategi, mempertimbangkan komponen biayapendidikan, lokasi dan optimalisasi promosi. Namun untuk PTS-PTS kecil dan lemah, hal tersebutbelum dilakukan sepenuhnya. Promosi yang dilakukan baru pada kegiatan penyebaran brosurdan iklan di media cetak atau elektronik saja, alasannya adalah keterbatasan dana dan SDM.
PENGEMBANGAN SUMBER DAYA MANUSIA DAN PRODUKTIVITAS KERJA PEGAWAI
Authors: Djuwita Tita Meirina
Published: August 2022

Investasi yang paling penting bagi organisasi adalah sumber daya manusia, di mana sumberdaya manusia merupakan kunci keberhasilan organisasi agar tetap bertahan dan berkembangdengan baik. Agar sumber daya manusia yang dimiliki organisasi dapat memberikan kontribusiyang maksimal, maka sumber daya manusia itu perlu dikembangkan baik melalui pendidikandan pelatihan. Pengembangan pegawai dapat terjadi secara formal ataupun informal dan sangatpenting untuk individu maupun organisasi. Pengembangan tersebut dibutuhkan sebagai bentukpenyesuian diri dengan kemajuan ilmu pengetahuan dan teknologi, oleh sebab itu programpengembangan pegawai harus dilakukan secara berkelanjutan dan dinamis. Anggapan terhadapproduktivitas kerja dapat dilihat sebagai sikap mental yang selalu mempunyai pandangan bahwakehidupan hari ini harus lebih baik daripada kemarin dan hari esok harus lebih baik daripada hariini. sikap yang demikian membuat seseorang selalu memperbaiki diri dan melakukan berbagaipeningkatan kualitas dirinya. Pegawai yang mempunyai sikap demikian akan terdoronng untukmenjadi dinamis, kreatif, dan terbuka di samping tetap kritis dan tanggap terhadap berbagaiide baru dan perubahan. Untuk hal tersebut diperlukan strategi pengembangan sumber dayamanusia yang tepat.
PENGARUH PERILAKU KEPEMIMPINAN TERHADAP KINERJA LAYANAN AKADEMIK PEGAWAI DI UNIVERSITAS PENDIDIKAN INDONESIA
Authors: Hariri Ridwan El
Published: August 2022

Universitas Pendidikan Indonesia adalah salah satu LPTK yang melayani jasa pendidikandan menyiapkan tenaga kependidikan guru. Pada saat ini kondisi pelayanan akademik olehpegawai administrasi dirasakan masih belum optimal, baik dari segi kualitas atau kuantitas.Kondisi tersebut menunjukkan bahwa kinerja pelayanan, khususnya pelayanan akademik olehpegawai UPI belum sepenuhnya memberikan kepuasan kepada pelanggan. Fenomena-fenomenayang terjadi mengindikasikan bahwa belum optimalnya kinerja pegawai administrasi UPI didugadipengaruhi oleh perilaku kepemimpinan, sehingga penelitian ini hendak mengkaji adakahpengaruh perilaku kepemimpinan terhadap kinerja layanan akademik di UPI Bandung. Metodepenelitian yang digunakan adalah Explanatory Survey Method, dengan teknik pengumpulandata angket, yang dikumpulkan dari responden sebanyak 110 orang pegawai administrasi UPI.Teknik analisis data adalah Model Analisis Jalur (Path Analysis Models) dengan uji statistikaadalah uji-t dan uji-F. Hasil penelitian menunjukkan bahwa: Perilaku kepemimpinan berpengaruhsecara signifikan terhadap kinerja layanan akademik pegawai UPI. Hal ini ditunjukkan olehadanya respon pegawai terhadap perilaku kepemimpinan yang dikembangkan oleh pimpinan UPIberdampak secara berarti terhadap kinerja mereka dalam pelayanan akademik bagi kepentinganpembelajaran.
PENGARUH IKLIM KERJA SEKOLAH DAN KINERJA MENGAJAR GURU TERHADAP MUTU BELAJAR SISWA (Studi pada Rintisan Sekolah Standar Nasional (RSSN) Sekolah Menengah Pertama Kabupaten Sumedang)
Authors: Sutarsanah Tuti
Published: August 2022

Permasalahan dalam penelitian merosotnya mutu belajar siswa disebabkan oleh iklimkerja sekolah dan kinerja mengajar guru yang kurang profesional.Metode penelitian adalah metode survey dengan pendekatan kuantitatif. Sampel diambilsecara random 84 guru dari populasi 530 guru Rintisan Sekolah Standar Nasional (RSSN)Sekolah Menengah Pertama Kabupaten Sumedang. Instrumen berupa angket dengan SkalaLikert, teknik analisis Korelasi Pearson Product Moment dan korelasi ganda.Hasil penelitian ditemukan bahwa pengaruh iklim kerja sekolah dan kinerja mengajar guruterhadap mutu belajar siswasebesar 63,52% sedangkan sisanya 36,48% ditentukan oleh variabellain seperti motivasi siswa; kemampuan siswa; sarana dan prasarana belajar siswa; disiplin guru;partisipasi orangtua; komunikasi guru; dan psikologi siswa. Direkomendasikan: (1) para guruhendaknya membina hubungan antar individu (interpersonal relationship) dan komunikasi yangbaik dan harmonis, (2) meningkatkan kinerja mengajar guru, melalui pendidikan dan pelatihan,kursus-kursus, dan seminar; (3) kepala sekolah agar memberikan kesempatan seluas-luasnyabagi para guru untuk meneruskan pendidikan kejenjang yang lebih tinggi.
Kepemimpinan dalam Perspektif Islam
Authors: Solihin M
Published: August 2022

Kepemimpinan dalam Perspektif Islam
Kepemimpinan Transformasi dan Budaya Organisasi
Authors: Suryadi Edi
Published: August 2022

Kepemimpinan Transformasi dan Budaya Organisasi
Pengaruh Efisiensi dan Efektivitas Sistem Teknologi Informasi Terhadap Peningkatan Daya Saing Perusahaan Software House
Authors: Munir Munir
Published: August 2022

Pengaruh Efisiensi dan Efektivitas Sistem Teknologi Informasi Terhadap Peningkatan Daya Saing Perusahaan Software House
Komunikasi dan Signifikasinya bagi Proses Dakwah Islamiyah
Authors: Solihin M
Published: August 2022

Komunikasi dan Signifikasinya bagi Proses Dakwah Islamiyah
Komputasi Statistik Analisis Jalur Melalui Aplikasi Program SPSS
Authors: Kusnendi Kusnendi
Published: August 2022

Komputasi Statistik Analisis Jalur Melalui Aplikasi Program SPSS
Budaya Organisasi dalam Lingkup Manajemen Stratejik
Authors: Sutarni Nani
Published: August 2022

Budaya Organisasi dalam Lingkup Manajemen Stratejik
ANALISIS PERANAN LEADERSHIP DAN BUDAYA ORGANISASI TERHADAP KINERJA PEGAWAI
Authors: Suryadi Edi
Published: August 2022

Organisasi merupakan wadah sekelompok orang yang memiliki tujuan yang ingin dicapai melalui orang-orang yang ada di dalamnya. Pencapaian melalui orang-orang tersebut merupakan kunci tercapainya tujuan yang telah ditentukan. Namun masih banyak masyarakat yang menilai keberhasilan suatu organisasi atau perusahaan dikaitkan dengan adanya proses produksi barang atau jasa yang berkualitas dan berkuant itas. Walaupun demikian jika ditelusuri lebih jauh, maka kita akan mendapatkan kenyataan bahwa bagian atau unsur penting bahkan terpenting di antara bagian-bagian tersebut adalah sumber daya manusia, personalia atau tenaga kerja. Karena kita ketahui faktor sumber daya manusia/ tenaga kerja merupakan pengendali dari seluruh akt ivitas perusahaan. Akan tetapi tujuan organisasi akan tercapai apabila didukung oleh kepempinan dan budaya organisasi yang baik uga sehingga kinerja pegawai akan meningkat. Dengan kinerja pegawai meningkat akan berindikasi pada kinerja organisasi juga.
SHARING DANA PENDIDIKAN DI JAWA BARAT
Authors: Permana Johar , Meirawan Danny , Triatna Cepi
Published: August 2022

Komitmen Gubernur Jawa Barat dan para bupati/walikota membutuhkan pola pembiayaanyang tepat sesuai dengan kebutuhan penyelenggaraan pendidikan yang bermutu. Penelitian ini bermaksud menggambarkan kondisi biaya operasional, biaya investasi, dan biaya personal pada sekolah bermutu tinggi, sedang dan rendah per siswa per tahun untuk  Sekolah Dasar (SD), Sekolah Menengah Pertama (SMP), dan Sekolah Menengah Atas (SMA)  di Jawa Barat, beserta peta pembiayaan pendidikan dasar dan menengah di Jawa Barat dilihat dari biaya operasi, investasi,  dan biaya personal. Penelitian ini menggunakan metode deskriptif, pendekatan kualitatif dan kuantitatif, populasi 26 kab./kota di Jawa Barat dengan asumsi homogenitas pada sumber penelitian ditetapkan secara purposif 12 kab./kota dengan 228 responden yang terdiri dari pihak sekolah, dinas pendidikan kab./kota, dan orang tua siswa. Temuan penelitian menunjukkan biaya operasional SD bermutu tinggi, sedang dan rendah per siswa per tahun mencapai masing-masing Rp 760,384.62; Rp Rp 388,320.92; dan 212,624.05. Di SMP sebesar Rp 1,634,722.26; Rp 503,651.39; dan Rp 241,179.80. Sedangkan di SMA sebesar Rp 2.140.417.00; Rp 1.524.909.00; dan Rp 951.721.00. Biaya investasi mencapai di SD, SMP, dan SMA per siswa per tahun pada sekolah yang dikategorikan bermutu tinggi, sedang, dan rendah masing-masing: SD: Rp 2,453,846.15; Rp 1,473,572.30; dan 28,190.84. di SMP: Rp 1,728,367.74; Rp 1,241,280.59; dan Rp 242,834.34. di SMA: Rp 5.329.500.000; Rp 713.905.000; dan Rp 384.226.500. Biaya personal pada kategori yang sama, di SD sebesar: Rp 11,788,000.00; Rp 3,163,450.00; dan 1,740,000.00. Di SMP mencapai Rp 8,930,000.00; Rp 5,209,300.00; dan Rp 2,720,000.00. Di SMA mencapai: Rp4.148.000,00; Rp 3.515.000,00, dan Rp 2.020.000,00. Pemda Propinsi Jabar juga memiliki peran yang signifikan dalam pembiayaan penyelenggaraan pendidikan dasar dan menengah (SD, SMP, dan SMA). Rata-rata pemenuhan biaya operasional untuk SD mencapai 6,44%, SMP mencapai 25,85% dan SMA mencapai 11,80%.
Additional Pathogenic Pathways in RBCK1 Deficiency
Authors: Demicheva E.I. , Shinwari K. , Ushenin K.S. , Bolkov M.A.
Published: August 2022

RBCK1 deficiency is a rare congenital autoinflammatory disease that causes inflammatory disruption on the molecular level. This deficiency has three major clinical manifestations: increased sensitivity to bacterial infections, autoinflammation syndrome, and the accumulation of amylopectin in skeletal muscle. The amylopectinosis causes myopathy and cardiomyopathy. The pathogenesis of the disease is poorly investigated and may include unnoticed relationships. We performed gene expression analysis on patients with RBCK1 deficiency and three other autoinflammatory diseases. The identification of differentially expressed genes revealed a large number of downregulated genes that are involved in the activation of essential metabolic and immune pathways, including NF-kB and Pi3k-Akt-mTOR. Signaling pathways were analysed using the KEGG (Kyoto Encyclopedia of Genes and Genomes) and Gene Ontology resource. Predicted protein-protein interactions were retrieved from the STRING (Search Tool for the Retrieval of Interacting proteins database). Besides the primary involvement of RBCK1 in disease pathology, several downregulated pathways aggravate symptoms of myopathy, cardiomyopathy, and bacterial disease. The studied pathways may serve as new targets for the development of compensatory therapies for patients with RBCK1 deficiency.
Survival in bladder cancer in Samara region taking into account the stage of the disease and location
Authors: Korabelnikov A. S. , Nizamova R. S. , Andreeva R. D. , Vozdvyzhensky M. O.
Published: August 2022

Background. Survival rates play an important role in improving the organization of oncological care and individualization of treatment methods. The presence of databases of patients with bladder cancer in the Samara region makes it possible to study survival at the population level, taking into account the place of residence, gender, stage of the disease, the histological structure of the tumor, and allows you to participate in the further formation of the federal cancer registry as part of the digitalization of healthcare.

Aim. To study of survival rates for bladder cancer in the Samara region for the period 2010–2012 with the calculation of 5-year survival for 2017.

Materials and methods. The study included data on 1138 patients with newly diagnosed bladder cancer. Calculation and analysis of relapse-free, overall and tumor-specific survival of 1059 patients with bladder cancer was carried out, taking into account the place of residence and gender differences. Of these, 846 (79.9 %) people are urban residents, 213 (20.1 %) are from rural areas (4:1). A comparative analysis of the survival of patients with bladder cancer for 2000–2002 and 2010–2012 was performed. The Kaplan–Meier method was used to calculate survival rates.

Results. An analysis of the survival of patients with bladder cancer found lower overall survival compared to tumor-specific survival, which indicates the presence of intercurrent causes of death. In the population of the region as a whole, 1-year relapse-free, overall and tumor-specific survival in this disease was 75.9, 77.9 and 81.1 %, 5-year – 55.7, 53.8 and 66.6 %, respectively. An assessment of the dynamics of the probability of living each year showed that the majority of patients (18.9 %) die during the first year of observation, in subsequent years the probability of survival is much higher. Life expectancy in urban areas is longer than in rural areas. Comparison of gender differences in survival revealed lower survival rates in the male population. Indicators of 1-year and 5-year tumor-specific survival of patients for 2010–2012 increased by 5.7 % and 13.6 %, respectively, as compared to 2000–2002.

Conclusion. Comparative analysis of 1-year and 5-year survival of patients with bladder cancer in the Samara region for 2010–2012 determined the low survival rates of rural men compared to urban ones. Higher survival rate for this disease for 2010–2012 compared to 2000–2002 may indicate an increase in the availability of specialist care to the population and careful monitoring of patients in the last decade of the study.
Efficacy of novel androgen axis inhibitors for the treatment of hormone-sensitive prostate cancer in patients with visceral metastases: a systematic review and meta-analysis
Authors: Murazov Ia. G. , Prokhorov D. G. , Tareev Yu. S. , Smirnov R. V.
Published: August 2022

Background. The presence of visceral metastases (VM) is a significant adverse prognostic factor affecting the overall survival of patients with metastatic hormone-sensitive prostate cancer (mHSPC). Recently, new drugs, such as novel antiandrogen therapies (NAT), have been introduced, expanding the options for the treatment of mHSPC.

Aim. To assess whether presence or absence of VM at baseline affects risk of death in patients with mHSPC receiving NAT therapy in combination with androgen deprivation therapy (ADT) compared with standard therapy (ADT ± 1st generation antiandrogen).

Search strategy. Bibliographic databases PubMed and Google Scholar were searched from inception through January 21, 2022.

Selection criteria. Eligible studies were randomized clinical trials with parallel design in patients with mHSPC. Subgroups of patients with or without VM at baseline were required. The following drugs were chosen as interventional agents: abiraterone acetate, apalutamide, enzalutamide, darolutamide. All in addition to ADT. The main outcome was overall survival.

Data analysis. We applied the inverse variance technique for the meta-analysis of hazard ratios (HR). In HR analysis we adopted a fixed-effect model.

Results. The analysis included three randomized clinical trials with 3376 patients, of which a total of 485 (14.4 %) patients had VM. Compared with ADT, the risk of death in patients with VM treated with NAT + ADT (HR 0.69; 95 % confidence interval (CI) 0.53–0.89; n = 485; p = 0.004) was similar to the risk of death in patients without VM (HR 0.66; 95 % CI 0.59–0.75; n = 2461; p <0.00001). The test for subgroup differences suggests that there is no statistically significant subgroup effect (χ2 = 0,05; df = 1; p = 0,82; I2 = 0 %). Ordered from the most to the least effective, treatments with improved overall survival in patients with VM when added to ADT included abiraterone acetate (HR 0.58; 95 % CI 0.41–0.82), apalutamide (HR 0.76; 95 % CI 0.47–1.23), enzalutamide (HR 1.05; 95 % CI 0.54–2.04). In patients without VM, the drugs are in the following order: enzalutamide (HR 0.62; 95 % CI 0.47–0.82), apalutamide (HR 0.65; 95 % CI 0.52–0.81), abiraterone acetate (HR 0.69; 95 % CI 0.58–0.82).

Conclusion. Patients with mHSPC benefit from the combination of NAT with ADT, regardless of the presence or absence of VM (HR 0.67; 95 % CI 0.60–0.75; n = 2946; p <0,00001). Abiraterone acetate has the greatest advantages in reducing the risk of death in patients with VM.
Tissue expression of the antiapoptotic protein survinin as a potential biomarker of prostate cancer
Authors: Aboyan I. A. , Fedotova E. N. , Lemeshko S. I. , Maksimov A. Yu. , Komarova E. F.
Published: August 2022

Background. Excessive expression of survivin is associated with inhibition of cell death, activated by extrinsic or intrinsic apoptotic pathways. The survininin overexpression has been shown in various malignancies, including lung cancer, pancreatic and breast cancer, colon cancer, oral squamous cell carcinoma and high grade non-Hodgkin lymphomas.

Aim. To investigate the level of survivin expression in prostate cancer tissues, and evaluate it as a diagnostic marker of prostate cancer.

Materials and methods. The level of survivin expression and its subcellular localization were assessed immunohistochemically in patients with prostate cancer (n = 64) and benign prostatic hyperplasia (n = 33). Tissue samples obtained at transrectal biopsy were used for analysis. Prostate cancer samples obtained after cystprostatectomy in patients with normal prostate specific antigen level and normal ultrasound findings (n = 36) were considered control tissue (norm).

Results. In prostate cancer group 3+ samples with a high level of survivin expression were present in 48.4 % of cases. In benign prostatic hyperplasia group the majority of samples were assessed as 2+, while 9.1 % of samples were negatively stained. 100 % of normal epithelium samples were negative. In patients with Gleason score <7 a survivin expression level was less than 3+ in 62.5 % of cases, and in patients with Gleason score >7 a highly positive reaction was detected in 68.8 % of cases. A high level of survivin expression was found in the large proportion of tissue samples at prostate specific antigen levels >10 ng/ml. Almost 50 % of highly positive cells were detected at a prostate health index (PHI) value of ≥60. The largest percentage of negative staining for surviving was common with PHI value <25. The degrees of staining for survining 1+ and 2+ prevailed in patients with prostate health index density (DPHI) <0.8, while a high level of prostate cells staining 3+ was observed at >0.8. As a Gleason score increase we observe the change of staining type for nucleocytoplasmic, and the largest number of samples has a staining degree of 2+ at a score GG4–5 (≥4 + 4). The type and frequency of prostate tissue samples staining were not differ depending on the initial prostate specific antigen level.

Conclusion. Immunohistochemical assessment of the survivin level, including its subcellular localization, could be considered as tumor-associated and a potential biomarker for differential diagnosis and prediction of prostate cancer course.
The Role of Political Connections in the Relationship Between Managerial Ability and Fraudulent Financial Statements
Authors: Ahmad Yahya Yeshua , Subroto Bambang , Atmini Sari
Published: August 2022

Research aims: This study seeks to prove empirical evidence regarding the effect of managerial ability on fraudulent financial statements.Design/Methodology/Approach: The population of this study was manufacturing firms listed on the Indonesia Stock Exchange in the 2017-2019 period. The data met the criteria of as many as 90 companies with a total of 270 observations. Then, hypothesis testing in this research used moderated regression analysis.Research findings: Study outcomes demonstrated that managerial ability positively impacted fraudulent financial statements. Furthermore, the positive influence of managerial ability on the fraudulent financial statement was weaker when the company was politically connected.Theoretical contribution/Originality: This study provides empirical evidence regarding the heterogeneity of managerial ability and political connections as predictors of fraudulent financial statements.Practitioner/Policy implication: The study result provides a reference for regulators to provide more effective oversight of companies with superior managerial capabilities and is politically connected.Research limitation/Implication: The limitations in this research can be considered to formulate further research related to variable measurement. In addition, no single measurement method can explain various conditions.
study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases
Authors: Mahamadou N. H BALLO , Youl Estelle N.H  , Karim Traore , Seidina Diakite A.S , Mamadou Diakite , Moussa Ouedraogo , Rokia Sanogo , Sekou Bah
Published: August 2022

Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes
ДОСЛІДЖЕННЯ УМОВ ФОРМУВАННЯ ФАХОВИХ КОМПЕТЕНЦІЙ МАЙБУТНІХ ФАХІВЦІВ У ГАЛУЗІ НАНОМАТЕРІАЛОЗНАВСТВА
Authors: Сичікова Яна Олександрівна , Богданов Ігор Тимофійович
Published: August 2022

У статті досліджено умови формування фахових компетенцій майбутніх фахівців у галузі наноматеріалознавства. Увагу зосереджено на здійснення продуктивної дослідницької діяльності. Такий підхід дозволить подолати наявні суперечності між моделями підготовки відповідних фахівців, з одного боку, та вимогами бізнесу, суспільства та держави до фахівців у професіях майбутнього, з іншого.
ПРАКТИКУМ ІЗ УДОСКОНАЛЕННЯ ПЕДАГОГІЧНОЇ МАЙСТЕРНОСТІ: ЯК СТВОРЮВАТИ ІНТЕРАКТИВНІ РЕЖИМИ ПРЕЗЕНТАЦІЙ НАВЧАЛЬНИХ ТЕКСТІВ
Authors: Скрипник Марина Іванівна , Кравчинська Тетяна Серігіївна , Волинець Наталія Петрівна
Published: August 2022

Розкрито практичні аспекти удосконалення педагогічної майстерності у створенні інтерактивних режимів презентацій навчальних курсів. Досліджено закон теорії візуальної аргументації та особливості представлення навчальної інформації в креолізованих текстах завдяки застосуванню цифрових інструментів.
МЕТОДОЛОГІЧНІ ЗАСАДИ ФОРМУВАННЯ МОВНОЇ І МОВЛЕННЄВОЇ КОМПЕТЕНТНОСТІ СТУДЕНТІВ ВНЗ
Authors: Трегубова Галина Миколаївна
Published: August 2022

У статті проаналізовано підходи до формування мовної і мовленнєвої компетентності студентів. Підкреслюється думка, що завдання вищої школи-готувати фахівців з високою мовленнєвою культурою.
Educação em direitos humanos: possibilidades a partir do PNEDH e do cinema na escola
Authors: Guerreiro Alexandre Silva
Published: August 2022

A luta pela instauração da Educação em direitos humanos em diversos países é decorrência direta da década dedicada à Educação (1995-2004) pelas Nações Unidas. Os Planos Nacionais de Educação em Direitos Humanos são, por sua vez, uma decorrência desse esforço, mas o hiato entre o que os planos estabelecem e as práticas pedagógicas persiste. Este trabalho tem por objetivo refletir sobre o PNEDH, publicado no Brasil em 2007, e as formas pelas quais podemos aproximar os direitos humanos da escola, em especial, através do cinema e do audiovisual. A partir de um estudo do PNEDH e de uma abordagem do cinema como arte na escola (BERGALA, 2002; FRESQUET, 2011; 2013), conclui-se que a tríade cinema-educação-direitos humanos é fundamental para que a escola atual seja reinventada, a partir da valorização e do protagonismo de alunas/alunos e professoras/professores.
Identidade de estudantes negras e negros: a experiência do projeto Afrocientista NEAB/GERA/UFPA
Authors: Coelho Wilma , Brito Nicelma , Dias Sinara
Published: August 2022

Este artigo integra as discussões relativas à juventude negra e à construção da identidade. Seu objetivo consiste em analisar o processo de construção da identidade de adolescentes-juvenis negras e negros no âmbito do Afrocientista do NEAB/GERA. O Projeto Afrocientista promoveu formações para 100 (cem) estudantes do Ensino Médio no país, com o objetivo, definido pela ABPN, de “aproximar os jovens negros e negras oriundos de baixas classes econômicas e com alto potencial de engajamento acadêmico e social ao ambiente acadêmico universitário”. No âmbito da UFPA, o NEAB GERA constituiu um desses Núcleos da Região Norte que integraram este projeto, com a participação de 11 (onze) estudantes de duas escolas públicas situadas na região metropolitana de Belém. Por meio dos conceitos de violência simbólica, identidade, juventudes e juventude negra, o artigo problematiza as formulações das adolescentes-juvenis sobre sua condição étnica, seu lugar no mundo e a sua relação com a escola. Ele discute ainda o potencial de iniciativas correlatas para a formação de adolescentes-juvenis negras e negros, com vistas a superação de desigualdades estruturais. Para tanto, foram analisados os depoimentos e percepções das adolescentes-juvenis ao longo do projeto mediante os Grupos de Discussão. Aqueles foram analisados por meio da metodologia de análise de conteúdo e estas últimas a partir da etnografia escolar. Concluiu-se que as adolescentes-juvenis partícipes deste projeto ampliaram seu suporte conceitual para fortalecer seu compromisso com as próprias trajetórias e a ampliação de suas expectativas de futuro.
As pesquisas sobre casos de ensino: uma revisão integrativa
Authors: Calil Ana Maria Gimenes Corrêa , Almeida Patrícia Albieri de , Tinti Douglas da Silva
Published: August 2022

O presente texto apresenta um balanço das tendências e características das produções sobre casos de ensino a partir de pesquisas realizadas no Brasil, no período de 2000 a 2020. Foram utilizados como corpus de análise os trabalhos apresentados nas reuniões anuais da Anped, as dissertações e teses disponíveis na Biblioteca Digital de Teses e Dissertações e, ainda, os artigos disponíveis no website do SciELO e do Educ@. Destacam-se nos achados da revisão o baixo número de produções em duas décadas. Os casos de ensino são utilizados nas pesquisas como dispositivo de formação, como instrumento de investigação ou para ambos os fins, o que representa a maioria. Observou-se uma concentração de estudos com professores da educação infantil, dos anos iniciais, da área de matemática e, também, aqueles que trabalham com alunos com deficiência. Nos demais segmentos, modalidades e áreas de conhecimento os estudos ainda são incipientes. As principais contribuições do uso de casos de ensino dizem respeito aos conhecimentos mobilizados pela sua utilização e ao papel da reflexão na análise das narrativas. O estudo evidencia a importância de uma agenda de pesquisa sobre casos de ensino na formação de professores que possa oferecer aos programas de formação inicial e continuada de professores não só os elementos da pedagogia baseada em casos, mas, sobretudo, um entendimento mais profundo do processo de aprender a ensinar.
Apresentação – Desafios da formação de professores para o ensino de Matemática
Authors: Pereira Patrícia Sândalo , Alencar Edvonete Souza de
Published: August 2022

Apresentação Seção Temática Desafios da formação de professores para o ensino da Matemática.
Apresentação: casos de ensino na pesquisa e formação docente: que conversa é essa?
Authors: Farias Isabel Maria Sabino de , Mussi Amali de Angelis
Published: August 2022

“Caso de ensino? Caso para ensino? Do que se trata? É sobre como ensinar?”. Nossa intenção, ao começar esta conversa remetendo a algumas indagações com que nos defrontamos no percurso da produção dessa Seção Temática sobre casos de ensino na pesquisa e na formação de professores, é demarcar a reduzida visibilidade desse assunto no debate educativo nacional, mas também evidenciar sua relevância e contribuição para o desenvolvimento de processos formativos e investigativos que explorem o pensamento, o conhecimento e a experiência docente.
Trabalho pedagógico na EJA EPT: considerações com base em estudo de uma realidade
Authors: Andrighetto Marcos José , Maraschin Mariglei Severo , Ferreira Liliana Soares
Published: August 2022

Este estudo objetivou analisar as orientações para o trabalho pedagógico na formação dos estudantes da EJA EPT, de um Instituto Federal do Rio Grande do Sul. A EJA EPT trata-se, portanto, de uma política educacional para formação integral dos estudantes, que possibilita o desenvolvimento humano, social e político juntamente com a profissionalização. Nesse sentido, realizou-se análise documental do Projeto Pedagógico do Curso (PPC) da EJA EPT, entendido como documento orientador do trabalho pedagógico no curso. Compreende-se que o Projeto Pedagógico é o texto que contém, quando efetivamente elaborado pelo coletivo, as disputas, os movimentos políticos, as tensões e contradições institucionais, as intencionalidades e os meios para alcançar os objetivos pedagógicos, configurando-se, portanto, em importante conteúdo que caracteriza como o trabalho pedagógico é projetado e deveria ser realizado na instituição. O estudo, de caráter qualitativo, tem como perspectiva teórico-metodológica a análise dialética. A técnica de produção de dados foi a análise documental e os dados produzidos foram analisados dialeticamente para entender os movimentos do trabalho pedagógico previsto para a formação dos estudantes da EJA EPT. Os resultados apontam para a necessidade de espaços de formação continuada e reuniões, além da fragilidade em se conferir a apenas um setor que compõe a instituição a responsabilidade sobre os processos educativos na mediação com o trabalho pedagógico dos professores.