bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation needs and temporal performance differences of gridded precipitation products in peripheral mountain regions
Authors: Zandler Harald , Haag Isabell , Samimi Cyrus
Published: October 2019

Gridded datasets are of paramount importance to globally derive precipitation quantities for a multitude of scientific and practical applications. However, as most studies do not consider the impacts of temporal and spatial variations of included measurements in the utilized datasets, we conducted a quantitative assessment of the ability of several state of the art gridded precipitation products (CRU, GPCC Full Data Product, GPCC Monitoring Product, ERA-interim, ERA5, MERRA-2, MERRA-2 bias corrected, PERSIANN-CDR) to reproduce monthly precipitation values at climate stations in the Pamir mountains during two 15 year periods (1980–1994, 1998–2012) that are characterized by considerable differences in incorporated observation data. Results regarding the GPCC products illustrated a substantial and significant performance decrease with up to four times higher errors during periods with low observation inputs (1998–2012 with 2 stations on average per 124,000 km2) compared to periods with high quantities of regionally incorporated station data (1980–1994 with 14 stations on average per 124,000 km2). If independent stations were considered, the coefficient of efficiency indicated that only three of the gridded datasets (MERRA–2 bias corrected, GPCC, GPCC MP) performed better than the long term station mean for characterizing surface precipitation. Error patterns and magnitudes show that in complex terrain, evaluation of temporal and spatial variations of included observations is a prerequisite for using gridded precipitation products for scientific applications and to avoid overly optimistic performance assessments.
The ant Lasius niger is a new source of bacterial enzymes with biotechnological potential for bleaching dye
Authors: Díez-Méndez Alexandra , García-Fraile Paula , Solano Francisco , Rivas Raúl
Published: October 2019

Industrial synthetic dyes cause health and environmental problems. This work describes the isolation of 84 bacterial strains from the midgut of the Lasius niger ant and the evaluation of their potential application in dye bioremediation. Strains were identified and classified as judged by rRNA 16S. The most abundant isolates were found to belong to Actinobacteria (49%) and Firmicutes (47.2%). We analyzed the content in laccase, azoreductase and peroxidase activities and their ability to degrade three known dyes (azo, thiazine and anthraquinone) with different chemical structures. Strain Ln26 (identified as Brevibacterium permense) strongly decolorized the three dyes tested at different conditions. Strain Ln78 (Streptomyces ambofaciens) exhibited a high level of activity in the presence of Toluidine Blue (TB). It was determined that 8.5 was the optimal pH for these two strains, the optimal temperature conditions ranged between 22 and 37 °C, and acidic pHs and temperatures around 50 °C caused enzyme inactivation. Finally, the genome of the most promising candidate (Ln26, approximately 4.2 Mb in size) was sequenced. Genes coding for two DyP-type peroxidases, one laccase and one azoreductase were identified and account for the ability of this strain to effectively oxidize a variety of dyes with different chemical structures.
Elevated preoperative platelet distribution width predicts poor prognosis in Esophageal Squamous Cell Carcinoma
Authors: Song Qian , Wu Jun-zhou , Wang Sheng , Chen Wen-hu
Published: October 2019

Activated platelets play a multifaceted role in tumorigenesis and progression. Platelet distribution width (PDW) is generally applied platelet parameters from routine blood test. Preoperative PDW has been considered a prognostic factor in many cancers. Nevertheless, the prognostic value of PDW in esophageal squamous cell carcinoma (ESCC) remains unknown. The study aimed to investigate whether preoperative PDW could serve as a prognostic factor in patients with ESCC. A total of 495 patients with ESCC undergoing curative surgery were enrolled. The relationship between PDW and clinical features in ESCC was analyzed using chi-square tests. Receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value. Overall survival (OS) and disease-free survival (DFS) stratified by PDW were evaluated by Kaplan–Meier method and log-rank test. Univariate and multivariate Cox regression were used to evaluate the prognostic effect of PDW. Of the 495 patients, elevated PDW was observed in 241(48.7%) of the patients, respectively. An elevated PDW was correlated with depth of tumor (T stage, P = 0.031), nerve infiltration (P = 0.016), hospital time after operation (P = 0.020), platelet (P < 0.001), red cell distribution width (P < 0.001), and aspartate transaminase (P = 0.001). Moreover, elevated PDW (PDW ≥ 13.4 fL) predicted a worse OS and DFS in patients with ESCC (both P < 0.001). Multivariate analyses revealed that PDW was independently associated with OS (hazard ratios 1.194; 95% confidence interval 1.120–1.273; P < 0.001) and DFS (hazard ratios 2.562; 95% confidence interval 1.733–3.786; P < 0.001). Our findings indicated that elevated PDW could serve as an independent worse survival in ESCC.
The “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ
Authors: Grune Tilman , Ott Christiane , Häseli Steffen , Höhn Annika , Jung Tobias
Published: October 2019

Measurement and quantification of cardiomyocyte or cardiac contractions as important (patho) physiologic parameters require highly specialized and expensive setups of fully integrated hard- and software that may be very difficult to use and may also depend on highly sophisticated methods of further data evaluation. With MYOCYTER (MC) we present a complete and highly customizable open-source macro for ImageJ, enabling fast, reliable user-friendly large scale analysis extracting an extensive amount of parameters from (even multiple) video recorded contracting cells or whole hearts, gained from a very competitive experimental setup. The extracted parameters enable extensive further (statistical) analysis to identify and quantify the effects of pathologic changes or drugs. Using videos following known mathematical functions, we were able to demonstrate the accuracy of MYOCYTER’s data extraction, also successfully applied the software to both cellular and animal models, introducing innovations like dynamic thresholding, automatic multi-cell recognition, “masked” evaluation and change of applied parameters even after evaluation.
In-Liquid Lateral Force Microscopy of Micropatterned Surfaces in a Fatty Acid Solution under Boundary Lubrication
Authors: Tsuchiko Masaki , Aoki Saiko
Published: October 2019

This study aims to investigate the influence of surface morphology on boundary-lubricated friction in a stearic acid solution. The surface morphology was controlled by fabricating submicrometer line-and-space patterns on Si(100) surface via photolithography. The boundary-lubricated friction on the patterns was measured by in-liquid lateral force microscopy for both transverse and longitudinal ridges, with respect to the sliding direction; the highest friction was observed on longitudinal ridges and grooves, which is in agreement with the tendency observed in our previous friction studies on steel surfaces. To further investigate this phenomenon, some additional patterns having different submicrometer morphologies were prepared and their friction characteristics were investigated. On the patterns not allowing the fluid to flow along the grooves, the frictional forces were equivalent for transverse and longitudinal grooves and ridges. Therefore, the high friction observed on the longitudinal ridges was caused by flowing out of fluid along the grooves, and it was possible to conclude that the fluidity around the submicrometer ridges and grooves influences the friction-reducing effect of stearic acid in boundary lubrication regime.
The anti-inflammatory agent bindarit acts as a modulator of fatty acid-binding protein 4 in human monocytic cells
Authors: Oddi Sergio , Scipioni Lucia , Totaro Antonio , Angelucci Clotilde , Dufrusine Beatrice , Sabatucci Annalaura , Tortolani Daniel , Coletta Isabella , Alisi Maria Alessandra , Polenzani Lorenzo , Assfalg Michael , Caltagirone Carlo , Dainese Enrico , Maccarrone Mauro
Published: October 2019

We investigated the cellular and molecular mechanisms by which bindarit, a small indazolic derivative with prominent anti-inflammatory effects, exerts its immunoregulatory activity in lipopolysaccharide (LPS) stimulated human monocytic cells. We found that bindarit differentially regulates the release of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1), enhancing the release of IL-8 and reducing that of MCP-1. These effects specifically required a functional interaction between bindarit and fatty acid binding protein 4 (FABP4), a lipid chaperone that couples intracellular lipid mediators to their biological targets and signaling pathways. We further demonstrated that bindarit can directly interact with FABP4 by increasing its expression and nuclear localization, thus impacting on peroxisome proliferator-activated receptor γ (PPARγ) and LPS-dependent kinase signaling. Taken together, these findings suggest a potential key-role of FABP4 in the immunomodulatory activity of bindarit, and extend the spectrum of its possible therapeutic applications to FABP4 modulation.
Treatment outcomes in patients with pyogenic vertebral osteomyelitis who have cirrhosis
Authors: Kim Jihye , Kang Ho Suk , Kim Jeoung Woo , Kim Seok Woo , Oh Jae-Keun , Kim Young-Woo , Park Moon Soo , Kim Tae-Hwan
Published: October 2019

Early diagnosis and proper treatment of pyogenic vertebral osteomyelitis (PVO) in patients with cirrhosis is challenging to clinicians, and the mortality rate is expected to be high. A retrospective study was conducted to investigate the treatment outcome in PVO patients with cirrhosis and to identify the predictors of their mortality. Mortality was divided into two categories, 30-day and 90-day mortality. A stepwise multivariate logistic regression model was used to identify predictors of mortality. Eighty-five patients were identified after initial exclusion. The patients’ mean age was 60.5 years, and 50 patients were male. The early mortality rates within 30 and 90 days were 17.6% and 36.5%, respectively. Multivariate analysis revealed that increased age, CTP class C, and bacteremia at the time of PVO diagnosis were predictors of 30-day mortality, while higher MELD score, presence of combined infection, and multiple spinal lesions were predictors of 90-day mortality. Attention should be paid to the high mortality between 30 and 90 days after PVO diagnosis (18.8%), which was higher than the 30-day mortality. Liver function was consistently a strong predictor of mortality in PVO patients with cirrhosis. The high-risk patients should be targeted for an aggressive diagnostic approach, using spinal MRI and intensive monitoring and treatment strategies.
A novel cellular structure in the retina of insectivorous birds
Authors: Tyrrell Luke P. , Teixeira Leandro B. C. , Dubielzig Richard R. , Pita Diana , Baumhardt Patrice , Moore Bret A. , Fernández-Juricic Esteban
Published: October 2019

The keen visual systems of birds have been relatively well-studied. The foundations of avian vision rest on their cone and rod photoreceptors. Most birds use four cone photoreceptor types for color vision, a fifth cone for achromatic tasks, and a rod for dim-light vision. The cones, along with their oil droplets, and rods are conserved across birds – with the exception of a few shifts in spectral sensitivity – despite taxonomic, behavioral and ecological differences. Here, however, we describe a novel photoreceptor organelle in a group of New World flycatchers (Empidonax spp.) in which the traditional oil droplet is replaced with a complex of electron-dense megamitochondria surrounded by hundreds of small, orange oil droplets. The photoreceptors with this organelle were unevenly distributed across the retina, being present in the central region (including in the fovea), but absent from the retinal periphery and the area temporalis of these insectivorous birds. Of the many bird species with their photoreceptors characterized, only the two flycatchers described here (E. virescens and E. minimus) possess this unusual retinal structure. We discuss the potential functional significance of this unique sub-cellular structure, which might provide an additional visual channel for these small predatory songbirds.
Impact of Synaptic Device Variations on Classification Accuracy in a Binarized Neural Network
Authors: Kim Sungho , Kim Hee-Dong , Choi Sung-Jin
Published: October 2019

Brain-inspired neuromorphic systems (hardware neural networks) are expected to be an energy-efficient computing architecture for solving cognitive tasks, which critically depend on the development of reliable synaptic weight storage (i.e., synaptic device). Although various nanoelectronic devices have successfully reproduced the learning rules of biological synapses through their internal analog conductance states, the sustainability of such devices is still in doubt due to the variability common to all nanoelectronic devices. Alternatively, a neuromorphic system based on a relatively more reliable digital-type switching device has been recently demonstrated, i.e., a binarized neural network (BNN). The synaptic device is a more mature digital-type switching device, and the training/recognition algorithm developed for the BNN enables the task of facial image classification with a supervised training scheme. Here, we quantitatively investigate the effects of device parameter variations on the classification accuracy; the parameters include the number of weight states (Nstate), the weight update margin (ΔG), and the weight update variation (Gvar). This analysis demonstrates the feasibility of the BNN and introduces a practical neuromorphic system based on mature, conventional digital device technologies.
Antigen array for serological diagnosis and novel allergen identification in severe equine asthma
Authors: White S. J. , Moore-Colyer M. , Marti E. , Hannant D. , Gerber V. , Coüetil L. , Richard E. A. , Alcocer M.
Published: October 2019

Severe equine asthma (sEA), which closely resembles human asthma, is a debilitating and performance-limiting allergic respiratory disorder which affects 14% of horses in the Northern Hemisphere and is associated with increased allergen-specific immunoglobulin E (IgE) against a range of environmental proteins. A comprehensive microarray platform was developed to enable the simultaneous detection of allergen-specific equine IgE in serum against a wide range of putative allergenic proteins. The microarray revealed a plethora of novel pollen, bacteria, mould and arthropod proteins significant in the aetiology of sEA. Moreover, the analyses revealed an association between sEA-affected horses and IgE antibodies specific for proteins derived from latex, which has traditionally been ubiquitous to the horse’s environment in the form of riding surfaces and race tracks. Further work is required to establish the involvement of latex proteins in sEA as a potential risk factor. This work demonstrates a novel and rapid approach to sEA diagnosis, providing a platform for tailored management and the development of allergen-specific immunotherapy.
Histological evidence of chitosan-encapsulated curcumin suppresses heart and kidney damages on streptozotocin-induced type-1 diabetes in mice model
Authors: Sudirman Sabri , Lai Ching-Shu , Yan Yi-Ling , Yeh Hung-I , Kong Zwe-Ling
Published: October 2019

High blood glucose in diabetic patients often causes cardiovascular diseases (CVDs) that threats to human life. Curcumin (Cur) is known as an antioxidant agent, possesses anti-inflammatory activity, and prevents CVDs. However, the clinical application of curcumin was limited due to its low bioavailability. This study aimed to investigate the ameliorative effects of chitosan-encapsulated curcumin (CEC) on heart and kidney damages in streptozotocin-induced type-1 diabetes C57BL/6 mice model. The results showed that Cur- and CEC-treatments downregulated the blood sugar and total cholesterol level as well as enhanced insulin secretion. However, blood pressure, triglycerides content, and very low-density lipoprotein-cholesterol content were not changed. Histochemistry analysis revealed that both curcumin and chitosan-encapsulated curcumin ameliorated cell hypertrophy and nucleus enlargement in the left ventricular of heart and reduced fibrosis in the kidney, especially after the chitosan-encapsulated curcumin treatment. Our study suggested that chitosan can effectively enhance the protective effect of curcumin on the heart and kidney damages in type-1 diabetes mice model.
Development of a high-productivity, halophilic, thermotolerant microalga Picochlorum renovo
Authors: Dahlin Lukas R. , Gerritsen Alida T. , Henard Calvin A. , Van Wychen Stefanie , Linger Jeffrey G. , Kunde Yuliya , Hovde Blake T. , Starkenburg Shawn R. , Posewitz Matthew C. , Guarnieri Michael T.
Published: October 2019

Microalgae are promising biocatalysts for applications in sustainable fuel, food, and chemical production. Here, we describe culture collection screening, down-selection, and development of a high-productivity, halophilic, thermotolerant microalga, Picochlorum renovo. This microalga displays a rapid growth rate and high diel biomass productivity (34 g m−2 day−1), with a composition well-suited for downstream processing. P. renovo exhibits broad salinity tolerance (growth at 107.5 g L−1 salinity) and thermotolerance (growth up to 40 °C), beneficial traits for outdoor cultivation. We report complete genome sequencing and analysis, and genetic tool development suitable for expression of transgenes inserted into the nuclear or chloroplast genomes. We further evaluate mechanisms of halotolerance via comparative transcriptomics, identifying novel genes differentially regulated in response to high salinity cultivation. These findings will enable basic science inquiries into control mechanisms governing Picochlorum biology and lay the foundation for development of a microalga with industrially relevant traits as a model photobiology platform.
Microarrays for the screening and identification of carbohydrate-binding peptides
Authors: Shastry Divya G. , Karande Pankaj
Published: October 2019

An integrated approach for the identification of carbohydrate-binding peptides is described, with a focus on the unique glycan polysialic acid.
A label-free fluorescent sensor based on silicon quantum dots–MnO2 nanosheets for the detection of α-glucosidase and its inhibitor
Authors: Liu Jinying , Duan Xinhe , Wang Mengke , Su Xingguang
Published: October 2019

We have successfully designed a fluorescence SiQD–MnO2 nanosheet sensing platform to detect α-glucosidase and acarbose for the first time.
Applications of hydrothermal synthesis of Escherichia coli derived carbon dots in in vitro and in vivo imaging and p-nitrophenol detection
Authors: Qin Kunhao , Zhang Dongfang , Ding Yafang , Zheng Xiaodan , Xiang Yingying , Hua Jianhao , Zhang Qi , Ji Xiuling , Li Bo , Wei Yunlin
Published: October 2019

The schematic of the synthesis route for fluorescent CDs-WT and the applications in the bioimaging and detection for p-NP is presented.
Thermodynamic control of quantum defects on single-walled carbon nanotubes
Authors: Maeda Yutaka , Murakoshi Hiyori , Tambo Haruto , Zhao Pei , Kuroda Kiyonori , Yamada Michio , Zhao Xiang , Nagase Shigeru , Ehara Masahiro
Published: October 2019

We designed and synthesized SWNT quantum defects, the band gaps of which can be tuned by thermal treatment. Theoretical calculations suggest that the change in the PL spectra can be explained by isomerization from kinetic to thermodynamic products.
Synergistic photothermal and photochemical partial oxidation of methane over noble metals incorporated in mesoporous silica
Authors: Jiang Haoyang , Peng Xiaobo , Yamaguchi Akira , Fujita Takeshi , Abe Hideki , Miyauchi Masahiro
Published: October 2019

We establish a hot-carrier-driven photothermal and photochemical system for partial oxidation of methane using noble metals incorporated in mesoporous silica.
A single-crystal-to-single-crystal transformation affording photochromic 3D MORF crystals
Authors: Yang Xue , Giorgi Michel , Karoui Hakim , Gigmes Didier , Hornebecq Virginie , Ouari Olivier , Kermagoret Anthony , Bardelang David
Published: October 2019

Metal–organic framework (MOF) type crystals in which rigid, viologen-based pillars are surrounded by cucurbit[7]uril (CB[7]) macrocycles are described.
Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles
Authors: Fang Songjia , Jiang Guangbin , Li Meng , Liu Zhenying , Jiang Huanfeng , Wu Wanqing
Published: October 2019

A palladium-catalyzed exclusively selective alkynylation of indoles has been reported, affording concise access to 7-alkynylindoles from readily available starting materials.
A paper-based chemosensor for highly specific, ultrasensitive, and instantaneous visual detection of toxic phosgene
Authors: Zeng Lintao , Zeng Hongyan , Wang Shuangfei , Wang Shan , Hou Ji-Ting , Yoon Juyoung
Published: October 2019

A chemosensor containing an o-hydroxyaniline unit as the reaction site was developed for colorimetric and fluorimetric detection of phosgene, which showed fast response (15 s), high specificity, and an extremely low detection limit.
Synthesis of C-terminal glycopeptidesviaoxime resin aminolysis
Authors: Tremblay Thomas , Robert-Scott Gabrielle , Bérubé Christopher , Carpentier Antoine , Voyer Normand , Giguère Denis
Published: October 2019

We developed a general solid-phase approach to complex C-terminal glycopeptides.
Visible-light-promoted oxidative halogenation of alkynes
Authors: Li Yiming , Mou Tao , Lu Lingling , Jiang Xuefeng
Published: October 2019

In nature, halogenation promotes the biological activity of secondary metabolites, especially geminal dihalogenation.
Binding affinities of cucurbit[n]urils with cations
Authors: Zhang Shuai , Grimm Laura , Miskolczy Zsombor , Biczók László , Biedermann Frank , Nau Werner M.
Published: October 2019

High binding constants of 19 inorganic cations with the cucurbit[n]uril homologues (CBn, n = 5, 6, 7, 8) in water were determined and the far-reaching consequences and interferences of the high affinities (millimolar to micromolar) are discussed.
Stereocontrolled construction of six vicinal stereogenic centers on a hexahydroxanthone framework through a formal [2+1+3] annulation
Authors: Chang Shun-Qin , Zou Xiong , Gong Yi , He Xue-Wen , Liu Xiong-Li , Zhou Ying
Published: October 2019

The first example of a bifunctional donor–donor 3C synthon formed in situ from an activated methine with nitromethane through a [2+1] Michael addition, further directing a one-pot organocascade Michael/Henry cycloaddition was developed.
In silico investigation of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP1
Authors: Catte Andrea , Ferbel Letizia , Bhattacharjee Nicholus , Jan Akhunzada Muhammad , D’Agostino Tommaso , Brancato Giuseppe
Published: October 2019

A computational study reveals a third site of interaction in the voltage-gated potassium channel Kv4.3 complexed with KChIP1 auxiliary protein.
Side chain effect on conjugated polymer/fullerene interfaces in organic solar cells: a DFT study
Authors: Ayoub Sarah A. , Lagowski Jolanta B.
Published: October 2019

We investigated the effect of lengths, types, and branching positions of side chains on the binding energies of monomer/fullerene pairings.
High-throughput HSE study on the doping effect in anatase TiO2
Authors: Liu Jiahua , Weng Mouyi , Li Sibai , Chen Xin , Cen Jianhang , Jie Jianshu , Xiao Weiji , Zheng Jiaxin , Pan Feng
Published: October 2019

Systematic study on the doping effects of anatase TiO2 doped with 40 kinds of elements by high-throughput HSE06 calculations.
Pd/Pt embedded CN monolayers as efficient catalysts for CO oxidation
Authors: Rao Yong-Chao , Duan Xiang-Mei
Published: October 2019

The catalytic performance of Pd/Pt embedded planar carbon nitride for CO oxidation has been investigated via spin-polarized density functional theory calculations.
Physicochemical and solution properties of quaternary-ammonium-salt-type amphiphilic trimeric ionic liquids
Authors: Kawai Risa , Yada Shiho , Yoshimura Tomokazu
Published: October 2019

The amphiphilic linear- and star-type trimeric ionic liquids show different melting point behaviours.
Influence of the pyrazine substituent on the structure and magnetic properties of dicyanamide-bridged cobalt(ii) complexes
Authors: Palion-Gazda Joanna , Choroba Katarzyna , Machura Barbara , Świtlicka Anna , Kruszynski Rafał , Cano Joan , Lloret Francesc , Julve Miguel
Published: October 2019

The SIM behaviour of the coordination polymers {[Co(dca)2(NH2pyz)2]·H2O}n1 and [Co3(dca)6(HOpyz)5(H2O)2]n2; [dca = dicyanamide; NH2pyz = 2-aminopyrazine; HOpyz = 2-hydroxypyrazine] has been investigated.
Creation and stabilisation of tuneable open metal sites in thiocyanato-bridged heterometallic coordination polymers to be used as heterogeneous catalysts
Authors: Tabe Hiroyasu , Matsushima Masaaki , Tanaka Rika , Yamada Yusuke
Published: October 2019

A series of {MII[PtIV(SCN)6]}n and {MII(CH3OH)x[PtIV(SCN)6]}n were characterised by single-crystal X-ray analyses and examined as heterogeneous catalysts to clarify the requisites for better catalysis.
One water-soluble polysaccharide from Ginkgo biloba leaves with antidepressant activities via modulation of the gut microbiome
Authors: Chen Peng , Hei Maofang , Kong Lili , Liu Yinyin , Yang Yu , Mu Haibo , Zhang Xiuyun , Zhao Shanting , Duan Jinyou
Published: October 2019

By performing a pyrosequencing-based analysis of bacterial community, we detected that one Ginkgo biloba polysaccharide reversed depression-associated gut dysbiosis and increased the richness of Lactobacillus species which has been proven to be a path to relieve depression.
Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice
Authors: Ding Yue , Xu Mingjuan , Lu Qun , Wei Ping , Tan Jun , Liu Rui
Published: October 2019

Honey may be considered as a good replacement of artificial sweeteners for diabetic patients because of its regulation effect on glucose metabolism.
A potentially general approach to aliphatic ester-derived PVC plasticizers with suppressed migration as sustainable alternatives to DEHP
Authors: Pan Siyu , Hou Delong , Chang Jinming , Xu Zhou , Wang Songhang , Yan Sunxian , Zeng Qi , Wang Zhonghui , Chen Yi
Published: October 2019

A potentially general and green approach based on Claisen condensation that enabled low-migrating aliphatic ester-derived PVC plasticizers as sustainable alternatives to DEHP was reported.
Hydrothermal pre-treatment coupled with urea solubilisation enables efficient protein extraction from microalgae
Authors: Karan Hakan , de Boeck Renée , Roles John , Hankamer Ben , Ross Ian L.
Published: October 2019

Hydrothermal pre-treatment (HTP) allows microalgal protein extraction. Subsequent acetone and urea treatments improve the extraction efficiency.
Dynamic thin film mediated slicing of boron nitride nanotubes
Authors: Al-antaki Ahmed Hussein Mohammed , Lawrance Warren D. , Raston Colin L.
Published: October 2019

A method has been developed to slice boron nitride nanotubes BNNTs under continuous flow in a vortex fluidic device (VFD), along with a method to partially purify the as received BNNT containing material.
Environmental fate descriptors for glycol-coated selenium nanoparticles: a quantitative multi-assay approach
Authors: Chaudhary Savita , Chauhan Pooja , Kumar Rajeev
Published: October 2019

The application of selenium nanoparticles (Se-NPs) in the fields of biological and physical science is escalating very fast.
A method for SNP detection using MoS2@AuNPs and SYBR Green I in combination with enzyme digestion
Authors: Yan Lirong , Deng Zebin , Shi Haixia , Xie Bing , Gao Li
Published: October 2019

Single-nucleotide polymorphisms (SNPs) in a gene sequence are markers for a variety of human diseases.
Heterojunction Cu2O/RGO/BiVO4ternary nanocomposites with enhanced photocatalytic activities towards degradation of rhodamine B and tetracycline hydrochloride
Authors: Hu Xiaoying , Zhang Qi , Nan Haoshan , Wang Ming , Qiao Liang , Tian Hongwei
Published: October 2019

The synergy of BVO, Cu2O and RGO inhibits the recombination of photogenic carriers to enhance the photocatalytic activity.
Ratiometric fluorescence determination of the anthrax biomarker 2,6-dipicolinic acid using a Eu3+/Tb3+-doped nickel coordination polymer
Authors: Lei Hang , Qi Cui-Xing , Chen Xuan-Bo , Zhang Tian , Xu Ling , Liu Bing
Published: October 2019

Tb3+0.6/Eu3+0.4@Ni-BTC is a quantitative ratiometric fluorescence sensor for DPA detection with high sensitivity, anti-interference, rapid response and durability.
Nanocellulose/graphene oxide layered membranes: elucidating their behaviour during filtration of water and metal ions in real time
Authors: Valencia Luis , Monti Susanna , Kumar Sugam , Zhu Chuantao , Liu Peng , Yu Shun , Mathew Aji P.
Published: October 2019

In situ SAXS and reactive molecular dynamics (ReaxFF) computational simulations of water and metal ion interaction with CNF–GO layered membranes.
Optimal ligand–receptor binding for highly efficient capture of vesicles in nanofluidic transportation
Authors: Xu Ziyang , Zhu Guolong , Chen Pengyu , Dai Xiaobin , Yan Li-Tang
Published: October 2019

Tailoring the intrinsic properties can be a versatile strategy in optimizing the ligand–receptor binding towards advantageous biomedical applications.
Effects of oral exposure to titanium dioxide nanoparticles on gut microbiota and gut-associated metabolism in vivo
Authors: Chen Zhangjian , Han Shuo , Zhou Di , Zhou Shupei , Jia Guang
Published: October 2019

The present study explored the role of gut microbiota and gut-associated metabolism in oral toxicity induced by TiO2 NPs.
Effect of nanotube coupling on exciton transport in polymer-free monochiral semiconducting carbon nanotube networks
Authors: Arias Dylan H. , Sulas-Kern Dana B. , Hart Stephanie M. , Kang Hyun Suk , Hao Ji , Ihly Rachelle , Johnson Justin C. , Blackburn Jeffrey L. , Ferguson Andrew J.
Published: October 2019

Exciton delocalization impacts complex interplay between rapid downhill exciton energy transfer and long-range energy transport through carbon nanotube networks.
Synthesis and chiroptical properties of cylindrical macrocycles comprising two calix[3]aramide moieties
Authors: Saito Yuuki , Satake Misa , Mori Ryuichi , Okayasu Misaki , Masu Hyuma , Tominaga Masahide , Katagiri Kosuke , Yamaguchi Kentaro , Kikkawa Shoko , Hikawa Hidemasa , Azumaya Isao
Published: October 2019

Novel chiral macrocyclic aromatic amides of medium molecular weight were synthesized by the one-step amide coupling of a bis(alkylamino)terphenyl diacid as monomer.
Thio radical-induced denitrogenative annulation of 1-azido-2-isocyanoarenes to construct 2-thiolated benzimidazoles
Authors: Li Dengke , Lei Jian
Published: October 2019

A method for the synthesis of 2-thiolated benzimidazoles is described starting from thiols and 1-azido-2-isocyanoarenes. The isocyano group works as an acceptor of various thio radicals, followed by denitrogenative annulation of the resulting imidoyl radical intermediates to the azido group, with nitrogen loss as the only process.
Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy
Authors: Ji Tan , Xia Lei , Zheng Wei , Yin Guang-Qiang , Yue Tao , Li Xiaopeng , Zhang Weian , Zhao Xiao-Li , Yang Hai-Bo
Published: October 2019

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.
Synthesis of indacenodithienothiophene-based conjugated polymers containing electron-donating/accepting comonomers and their phototransistor characteristics
Authors: Moon Yejin , Lee Chulyeon , Kim Hwajeong , Park Jisu , Kim Youngkyoo
Published: October 2019

IDTT-based conjugated polymers with electron-accepting comonomers exhibit higher hole mobility (10-fold) and photoresponsivity (2-fold) than those with electron-donating comonomers.
Selective oxidation of methacrolein to methacrylic acid over H4PMo11VO40/C3N4-SBA-15
Authors: Zhou Lilong , Zhang Shanshan , Li Zhengjie , Scott Jason , Zhang Zhikun , Liu Runjing , Yun Jimmy
Published: October 2019

Molybdovanadylphosphoric acid (HPMV) was supported on a carbon nitride-modified SBA-15 (CN-SBA-15) molecular sieve to enhance its catalytic performance for oxidation of methacrolein (MAL) to methacrylic acid (MAA).
cRGD functionalized 2,1,3-benzothiadiazole (BTD)-containing two-photon absorbing red-emitter-conjugated amphiphilic poly(ethylene glycol)-block-poly(ε-caprolactone) for targeted bioimaging
Authors: Wu Shanshan , Su Fengyu , Magee Hansa Y. , Meldrum Deirdre R. , Tian Yanqing
Published: October 2019

A two-photon absorbing (2PA) red emitter group was chemically conjugated onto amphiphilic poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) copolymers, and further grafted with cyclo(Arg-Gly-Asp) (cRGD) peptide to form micelle 1.
Near-field infrared microscopy of nanometer-sized nickel clusters inside single-walled carbon nanotubes
Authors: Németh Gergely , Datz Dániel , Pekker Áron , Saito Takeshi , Domanov Oleg , Shiozawa Hidetsugu , Lenk Sándor , Pécz Béla , Koppa Pál , Kamarás Katalin
Published: October 2019

Nickel nanoclusters grown inside single-walled carbon nanotubes (SWCNT) were studied by infrared scattering-type scanning near-field optical microscopy (s-SNOM).
An advanced and efficient Co3O4/C nanocomposite for the oxygen evolution reaction in alkaline media
Authors: Mugheri Abdul Qayoom , Tahira Aneela , Aftab Umair , Abro Muhammad Ishaq , Mallah Arfana Begum , Memon Gulam Zuhra , Khan Humaira , Abbasi Mazhar Ali , Halepoto Imran Ali , Chaudhry Saleem Raza , Ibupoto Zafar Hussain
Published: October 2019

The design of efficient nonprecious catalysts for the hydrogen evolution reaction (HER) or the oxygen evolution reaction (OER) is a necessary, but very challenging task to uplift the water-based economy.
Nitrogen aeration alters the spatial distribution and metal adsorption of extracellular polymeric substances in waste-activated sludge
Authors: Liu Ying , Lv Wenzhou , Xia Siqing , Zhang Zhiqiang
Published: October 2019

Nitrogen aeration was superior to air aeration because of the higher EPS production and Pb2+adsorption in the utilization of WAS.
Structural tuning enables piezochromic and photochemical properties in N-aryl-β-enaminones
Authors: Hsieh Wan-Chi , Manjappa Kiran B. , Yang Ding-Yah
Published: October 2019

N-Aryl-β-enaminones are synthesized via Et3N-mediated, one-pot three-component reaction of 4-hydroxycoumarin/dimedone, β-nitrostyrene/2-(2-nitrovinyl)thiophene and arylamine, and their piezochromic behavior and photosensitivity explored.
Generation of hydrogen sulfide during the thermal enhanced oil recovery process under superheated steam conditions
Authors: Ma Qiang , Yang Zhengda , Zhang Liqiang , Lin Riyi , Wang Xinwei
Published: October 2019

During the thermal enhanced oil recovery process, the hazardous hydrogen sulfide (H2S) gas among the produced gases increases with superheated degree of vapor, which causes significant difficulty in the exploration and development of petroleum.
Isothiourea-catalysed enantioselective Michael addition of N-heterocyclic pronucleophiles to α,β-unsaturated aryl esters
Authors: Shu Chang , Liu Honglei , Slawin Alexandra M. Z. , Carpenter-Warren Cameron , Smith Andrew D.
Published: October 2019

The isothiourea-catalysed enantioselective Michael addition of 3-aryloxindole and 4-substituted-dihydropyrazol-3-one pronucleophiles to α,β-unsaturatedp-nitrophenyl esters is reported.
Thinking outside the “Blue Box”: from molecular to supramolecular pH-responsiveness
Authors: Blanco-Gómez Arturo , Neira Iago , Barriada José L. , Melle-Franco Manuel , Peinador Carlos , García Marcos D.
Published: October 2019

We present herein the development of a new polycationic cyclophane: the “red box”, second in a series of hydrazone-based analogues of the well-known organic receptor cyclobis(paraquat-p-phenylene)cyclophane (“blue box”).
Reaction mechanism, norbornene and ligand effects, and origins of meta-selectivity of Pd/norbornene-catalyzed C–H activation
Authors: Yang Tao , Kong Chuncai , Yang Shengchun , Yang Zhimao , Yang Sen , Ehara Masahiro
Published: October 2019

Density functional theory calculations disclosed the key steps of Pd/norbornene-catalyzed meta-C–H functionalization.
Biomass-derived wearable energy storage systems based on poplar tree-cotton fibers coupled with binary nickel–cobalt nanostructures
Authors: Hekmat Farzaneh , Unalan Husnu Emrah , Shahrokhian Saeed
Published: October 2019

We demonstrated symmetric and asymmetric supercapacitors (SSCs and ASCs) based on core/shell-like Ni–Co oxide@cotton//Fe2O3–carbon nanotubes@cotton that are capable of storing a remarkable amount of energy, while retaining a high power density and long cycle life.
Capillary assemblies in a rotating magnetic field
Authors: Grosjean Galien , Hubert Maxime , Collard Ylona , Sukhov Alexander , Harting Jens , Smith Ana-Sunčana , Vandewalle Nicolas
Published: October 2019

The rotational dynamics of magnetocapillary assemblies is studied, aiming to design and understand self-assembled microswimmers and micromixers.
ZIF-67-derived Co3O4@carbon protected by oxygen-buffering CeO2as an efficient catalyst for boosting oxygen reduction/evolution reactions
Authors: Li Xuerui , You Shijie , Du Jiannan , Dai Ying , Chen Hun , Cai Zhuang , Ren Nanqi , Zou Jinlong
Published: October 2019

The oxygen-buffering CeO2effectively protects the available active sites of the ZIF-67-derived Co3O4@carbon to improve oxygen reduction/evolution reaction activities.
Synergistic effect of charge separation and defect passivation using zinc porphyrin dye incorporation for efficient and stable perovskite solar cells
Authors: Zhou Yu , Zhong Han , Han Jianhua , Tai Meiqian , Yin Xuewen , Zhang Minghua , Wu Ziyi , Lin Hong
Published: October 2019

A zinc porphyrin dye (YD2-o-C8) was incorporated into perovskite films via a simple anti-solvent dripping method. The synergistic effect of charge separation and defect passivation enables perovskite solar cells with enhanced efficiency and stability.
Lotus rhizome-like S/N–C with embedded WS2 for superior sodium storage
Authors: Li Xiu , Sun Yonggang , Xu Xun , Wang Yun-Xiao , Chou Shu-Lei , Cao Anmin , Chen Libao , Dou Shi-Xue
Published: October 2019

A delicate method is developed to embed WS2 nanosheets into lotus rhizome-like heteroatom-doped carbon nanofibers with abundant hierarchical tubes inside. The nanofibers exhibit enhanced performance in sodium-ion batteries.
Two-dimensional group-VA nanomaterials beyond black phosphorus: synthetic methods, properties, functional nanostructures and applications
Authors: Gui Rijun , Jin Hui , Sun Yujiao , Jiang Xiaowen , Sun Zejun
Published: October 2019

This review summarizes recent advances on synthesis, properties, functional nanostructures and applications of two-dimensional group-VA nanomaterials beyond black phosphorus.
Unveiling the mechanism of improved capacity retention in Pmn21 Li2FeSiO4 cathode by cobalt substitution
Authors: Zeng Yan , Chiu Hsien-Chieh , Ouyang Bin , Song Jun , Zaghib Karim , Demopoulos George P.
Published: October 2019

Substitution of cobalt in Li2FeSiO4 improves capacity retention by facilitating phase transformation and forming beneficial cathode-electrolyte interfacial layer.
PEGylated reduced-graphene oxide hybridized with Fe3O4nanoparticles for cancer photothermal-immunotherapy
Authors: Wang Lu , Wang Meng , Zhou Benqing , Zhou Feifan , Murray Cynthia , Towner Rheal A. , Smith Nataliya , Saunders Debra , Xie Gang , Chen Wei R.
Published: October 2019

A novel nanocomposite was designed by hybridizing Fe3O4with reduced-graphene oxide for imaging-guided photothermal-immunotherapy. It is an excellent agent for phototherapy to facilitate a tumor-specific immune response to inhibit tumor metastasis.
Reprogramming bacteria with RNA regulators
Authors: Apura Patrícia , Domingues Susana , Viegas Sandra C. , Arraiano Cecília M.
Published: October 2019

The revolution of genomics and growth of systems biology urged the creation of synthetic biology, an engineering discipline aiming at recreating and reprogramming cellular functions for industrial needs. There has been a huge effort in synthetic biology to develop versatile and programmable genetic regulators that would enable the precise control of gene expression. Synthetic RNA components have emerged as a solution, offering a diverse range of programmable functions, including signal sensing, gene regulation and the modulation of molecular interactions. Owing to their compactness, structure and way of action, several types of RNA devices that act on DNA, RNA and protein have been characterized and applied in synthetic biology. RNA-based approaches are more ‘economical' for the cell, since they are generally not translated. These RNA-based strategies act on a much shorter time scale than transcription-based ones and can be more efficient than protein-based mechanisms. In this review, we explore these RNA components as building blocks in the RNA synthetic biology field, first by explaining their natural mode of action and secondly discussing how these RNA components have been exploited to rewire bacterial regulatory circuitry.
The Effects of Duration and Level on Spectral Modulation Perception
Authors: Isarangura Sittiprapa , Eddins Ann C. , Ozmeral Erol J. , Eddins David A.
Published: October 2019

Purpose

Spectral modulation detection is an increasingly common assay of suprathreshold auditory perception and has been correlated with speech perception performance. Here, the potential effects of stimulus duration and stimulus presentation level on spectral modulation detection were investigated.

Method

Spectral modulation detection thresholds were measured as a function of modulation frequency in young, normal-hearing listeners. The standard stimulus was a bandpass noise, and signal stimuli were created by superimposing sinusoidal spectral modulation on the bandpass noise carrier. The modulation was sinusoidal on a log
2
frequency axis and a log
10
(dB) amplitude scale with a random starting phase (0–2π radians). In 1 experiment, stimulus durations were 50, 100, 200, or 400 ms (at fixed level 81 dB SPL). In a 2nd experiment, stimuli were presented at sensation levels of 10, 20, 30, 40, and 60 dB SL (fixed at a duration of 400 ms).

Results

Spectral modulation detection thresholds were similarly low for the 400- and 200-ms durations, increased slightly for the 100-ms duration, and increased markedly for the 50-ms duration. Thresholds were lowest for 40 dB SL; increased slightly for 20, 30, and 60 dB SL; and markedly higher for the 10–dB SL condition.

Conclusions

The increase in thresholds for the shortest durations and lowest sensational levels is consistent with previous investigations of auditory spectral profile analysis. The effects of presentation level and stimulus duration are important considerations in the context of understanding potential relationships between the perception of spectral cues and speech perception, when designing investigations and interpreting data related to spectral envelope perception, and in the context of models of auditory perception. As examples, 2 simple models based on auditory nerve output that have been used to explain spectrotemporal modulation in previous investigations produced an output inconsistent with the present results.

Plain language summary

Intensity variations across audio frequency lead to spectral shapes that are essential and sometimes signature features of various sounds in the environment, including speech. Here, we show how laboratory measures of spectral shape perception depend on presentation level and stimulus duration.
Graduate Students' Perspectives on Integrating Clinical Experiences and Coursework on Autism Spectrum Disorder: A Pilot Study
Authors: Benigno Joann P. , McCarthy John , Reese Pam Britton , Wright Bridget M. , Tewanger Carley
Published: October 2019

Purpose

The aim of this study was to examine the goals, outcomes, and skills attained by graduate students participating in a clinical experience paired with a course on autism spectrum disorder (ASD).

Method

Twenty-four graduate student clinicians (23 females, 1 male) participated in the experience. Students provided services within social communication groups for children with ASD. Students were assigned 1 of 4 primary service-roles: communication partner, parent educator, lesson planner, and support staff. All student clinicians completed pre- and posttest assessments regarding their goals and desired outcomes. Students also rated the value and importance of clinical skills and integrating classroom content with clinical experiences.

Results

Students' ratings of the value and confidence of the clinical skills queried did not change from pre- to posttest. However, significant differences emerged between students' value and confidence ratings within the pre- and posttest time points. Students achieved the majority of the goals and desired outcomes for learning more about ASD and gaining clinical and treatment skills by the end of the experience. All students rated the importance of integrating clinical and classroom experience highly at both pre- and posttest.

Conclusion

Clinical experiences that infuse and reinforce classroom material support students' goal attainment and clinical skill development. Further research exploring graduate students' perspectives on training programs such as the one described in this study is warranted.
Developing a Culture of Successful Communication in Acute Care Settings: Part II. Solving Institutional Issues
Authors: Marshall Sarah , Hurtig Richard R.
Published: October 2019

Purpose

Establishing services for hospitalized patients with complex communication needs (CCNs) requires identifying and addressing both patient-based and institutional barriers. Although the previous paper (
Marshall & Hurtig, 2019
) focused on patient-based barriers, this paper addresses overcoming institutional barriers.

Method

We present a series of cases to illustrate the institutional challenges in meeting the CCNs of patients in an acute care setting.

Results

Each case illustrates how the deployment of augmentative and alternative communication tools required addressing institutional/systems barriers and how critical collaborations help patients with CCNs to more effectively communicate with caregivers and participate in their care.

Conclusion

Building a culture of improved patient–provider communication involves establishing a wider range of interprofessional collaborations and shared resources in order to effectively provide patients with CCNs the tools to summon assistance and communicate with their caregivers.