bluuebunny/crossref_metadata_2025 huggingface dataset:
Skull vibration induced nystagmus, velocity storage and self-stability
Authors: Curthoys Ian S. , Zee David S. , Dumas Georges , Pastras Christopher J. , Dlugaiczyk Julia
Published: February 2025

In this paper we give an introduction to the area, followed by brief reviews of the neural response to sound and vibration, and then the velocity storage integrator, before putting forward our hypothesis about the neural input to the velocity storage integrator. Finally we discuss some of the implications of our hypothesis. There are two pathways conveying neural information from the vestibular periphery (the semicircular canals and the otoliths) to central neural mechanisms—a direct and an indirect pathway. Within the indirect pathway there is a unique neural mechanism called the velocity storage integrator (VSI) which is part of a neural network generating prolonged nystagmus, afternystagmus and the sensation of self-motion and its converse self-stability. It is our hypothesis that only neural input from primary afferent neurons with irregular resting discharge projects in the direct pathway, whereas the primary afferent input in the indirect pathway consists of neurons with regular resting discharge. The basis for this hypothesis is that vibration is a selective stimulus for vestibular neurons with irregular resting discharge. 100 Hz mastoid vibration, while capable of generating nystagmus (skull vibration induced nystagmus SVIN), is ineffective in generating afternystagmus (in the condition of an encased labyrinth) which is a marker of the action of the VSI, leading to the conclusion that irregular afferents bypass the indirect pathway and the VSI. In order to present this hypothesis we review the evidence that irregular neurons are selectively activated by sound and vibration, whereas regular neurons are not so activated. There are close similarities between the temporal characteristics of the irregular afferent neural response to vibration and the temporal characteristics of SVIN. SVIN is a simple clinical indicator of whether a patient has an imbalance between the two vestibular labyrinths and our hypothesis ties SVIN to irregular primary vestibular neurons.
Autoantibodies in myasthenia gravis: cluster analysis and clinical correlations
Authors: Sun Xupeng , Qu Meijie , Rong Xi , Lv Mingxing , Zhao Yunbin , Yan Yunjun , Liu Lin , Sun Na , Yue Hua , Liu Min
Published: February 2025

Objective

This study aimed to explore autoantibody clusters and their correlations with clinical features in 644 myasthenia gravis (MG) patients.

Methods

Medical records of 664 MG patients were reviewed. Five autoantibodies (AChR, MuSK, titin, RyR, and LRP4) were selected for cluster analysis. The various clinical manifestations were compared between clusters. Separate association analyses between individual autoantibodies and clinical manifestations as well as among different MGFA subtypes were also performed without prior clustering.

Results

Two separate autoantibody clusters were identified, with significantly different clinical manifestations. Cluster 1 (485 patients) was characterized by higher proportions of RyR-, titin-, and AChR-, while cluster 2 (179 patients) had higher proportions of RyR+, titin+, and AChR+. Cluster 2 patients were older and had elevated QMG scores and odds of complications, particularly hypertension, diabetes, cardiovascular and cerebrovascular diseases, and eye conditions. Individual antibody analysis revealed that male cases were more likely to be AChR+ and titin+, and older age was associated with AChR+, RyR+, and titin+. Among MGFA subtypes, significant differences were detected in AChR, MuSK, titin, complications, thymoma, and hypertension. As MG severity increased from types I to V, AChR+, RyR+, and titin+ proportions peaked at stage IIa. MuSK+ patients were relatively rare and mostly present in the subtype b group. Type b patients had higher MuSK+ prevalence and increased cardiovascular and cerebrovascular disease incidence rates than type a cases.

Conclusion

Overall, cluster 2 features were less favorable to patients. This study provides valuable insights into the clinical and autoantibody profiles of Chinese MG patients.
Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID
Authors: Smadja David M. , Abreu M. Marc
Published: February 2025

Neurodegenerative diseases (NDs) and Long COVID represent critical and growing global health challenges, characterized by complex pathophysiological mechanisms including neuronal deterioration, protein misfolding, and persistent neuroinflammation. The emergence of innovative therapeutic approaches, such as whole-body hyperthermia (WBH), offers promising potential to modulate underlying pathophysiological mechanisms in NDs and related conditions like Long COVID. WBH, particularly in fever-range, enhances mitochondrial function, induces heat shock proteins (HSPs), and modulates neuroinflammation—benefits that pharmacological treatments often struggle to replicate. HSPs such as HSP70 and HSP90 play pivotal roles in protein folding, aggregation prevention, and cellular protection, directly targeting pathological processes seen in NDs like Alzheimer's, Parkinson's, and Huntington's disease. Preliminary findings also suggest WBH's potential to alleviate neurological symptoms in Long COVID, where persistent neuroinflammation and serotonin dysregulation are prominent. Despite the absence of robust clinical trials, the therapeutic implications of WBH extend to immune modulation and the restoration of disrupted physiological pathways. However, the dual nature of hyperthermia's effects—balancing pro-inflammatory and anti-inflammatory responses—emphasizes the need for dose-controlled applications and stringent patient monitoring to minimize risks in vulnerable populations. While WBH shows potential interest, significant challenges remain. These include individual variability in response, limited accessibility to advanced hyperthermia technologies, and the need for standardized clinical protocols. Future research must focus on targeted clinical trials, biomarker identification, and personalized treatment strategies to optimize WBH's efficacy in NDs and Long COVID. The integration of WBH into therapeutic paradigms could mark a transformative step in addressing these complex conditions.
Benign regulation of short-chain fatty acids: the underlying mechanism of the beneficial effects of manual acupuncture on cognitive ability and the intestinal mucosal barrier in APP/PS1 mice
Authors: Ding Ning , Hao Xin , Zhang Yue , Zhang Yanxiang , Li Zhigang
Published: February 2025

Background

Gut microbiota dysbiosis is closely related to the occurrence and progression of Alzheimer’s disease (AD). The destruction of the intestinal mucosal barrier caused by a decrease in short-chain fatty acids (SCFAs) plays a key role in gut microbiota dysbiosis-induced neuroinflammation in AD. Our previous research confirmed for the first time that manual acupuncture (MA) can benignly modulate gut microbiota dysbiosis, alleviating the destruction of the intestinal mucosal barrier. However, the regulatory effect of MA on SCFAs remains elusive, and the underlying mechanism by which MA improves intestinal mucosal barrier function requires elucidation.

Methods

In the APP/PS1 manual acupuncture (Am) group, MA was applied at Baihui (GV20), Yintang (GV29), and Zusanli (ST36). Probiotics were delivered to the APP/PS1 probiotic (Ap) group. Alterations in spatial learning and memory, intestinal barrier function, SCFAs in feces and serum, the expression of FFAR3 and NF-κB, and inflammatory cytokines were evaluated in each group.

Results

Compared with those in the C57BL/6 control (Cc) group, cognitive ability was significantly decreased, SCFAs and FFAR3 expression were obviously decreased, intestinal barrier integrity was drastically impaired, and the expression of NF-κB and the levels of intestinal IL-1β and TNF-α were increased in the APP/PS1 control (Ac) group. These changes were reversed by MA and probiotics.

Conclusion

MA can significantly reduce intestinal inflammation and alleviate destruction of the intestinal mucosal barrier in APP/PS1 mice. SCFAs/FFAR3/NF-κB may be important targets through which MA benignly regulates intestinal mucosal barrier function.
The association between the interval from biopsy to radical prostatectomy and biochemical recurrence in patients with intermediate- and high-risk prostate cancer
Authors: Siech Carolin , Wenzel Mike , Knoblich Georgina , Cano Garcia Cristina , Humke Clara , Preisser Felix , Traumann Miriam , Kluth Luis A. , Chun Felix K. H. , Mandel Philipp
Published: February 2025

Objective

To investigate the association between the interval from biopsy to radical prostatectomy (RP) and biochemical recurrence (BCR) in prostate cancer patients.

Methods

Within a tertiary-care database (01/2014 to 06/2023), D’Amico intermediate- and high-risk prostate cancer patients were stratified according to interval from biopsy to RP (≤3 vs. >3-≤6 months). Kaplan-Meier survival analyses and Cox regression models addressed BCR.

Results

Of 680 patients, 328 vs. 153 exhibited intermediate-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Similarly, 158 vs. 41 exhibited high-risk prostate cancer and had interval from biopsy to RP ≤3 vs. >3-≤6 months. Median interval from biopsy to RP was 59 vs. 113 days in intermediate- and 55 vs. 117 days in high-risk patients, respectively. In both intermediate- and high-risk patients, rates of adverse histopathological outcomes, namely pT3/pT4, pN1, and R1 status, did not differ according to interval from biopsy to RP. In survival analyses, three-year BCR-free survival rates were 82 vs. 88% in intermediate-risk (p=0.5) and 76 vs. 75% in high-risk patients (p=1). In multivariable Cox regression models, BCR did not significantly differ according to interval from biopsy to RP in intermediate- (hazard ratio 0.85, 95% confidence interval 0.49-1.46; p=0.5) and high-risk patients (hazard ratio 1.05, 95% confidence interval 0.50-2.22; p=0.9).

Conclusions

Both intermediate- and high-risk prostate cancer patients with an interval from biopsy to RP >3-≤6 months did not differ from those treated with RP ≤3 months after biopsy, regarding adverse histopathological outcomes and BCR rates. Therefore, it might be safe to postpone RP up to six months.
Research trends on lymphedema after mastectomy for breast cancer patients from 2000 to 2023: a scientometric analysis
Authors: Chen Ling , Zheng Yuxian , Zheng Daitian , Li Zhiyang , Chen Hongwu , Chen Chujun , Yu Shuxian
Published: February 2025

Background

Breast cancer-related lymphedema (BCRL) is a common and debilitating complication following breast cancer treatment. Despite its significant impact on patients’ quality of life, bibliometric analyses focusing on BCRL are scarce. This study aims to explore global research trends on BCRL from 2000 to 2023, identify existing knowledge gaps, and highlight emerging focus areas through a bibliometric approach.

Methods

A comprehensive search was conducted using the Web of Science (WOS) database to retrieve literature published between January 2000 and November 2023. Bibliometric analyses and visualizations were performed using R Studio, CiteSpace, and VOSviewer. Key data extracted included publication trends, contributing countries and institutions, leading authors, journals, research categories, and keywords. Outcome measures for analysis included the number of publications, citation counts, author productivity, and keyword co-occurrence.

Results

A total of 919 eligible publications from 52 countries and regions, 1,163 institutions, and 3,550 authors were identified. These publications appeared in 255 journals, with “Lymphology” emerging as the journal with the highest citation count. The USA was the most prolific contributor to the field. The annual number of publications demonstrated a consistent upward trend. Keyword co-occurrence analysis revealed prominent research hotspots, including “lymphedema,” “women,” “breast cancer,” “arm lymphedema,” and “quality of life.” Emerging keyword trends from 2021 to 2023 highlighted “prevention” and “validity” as pivotal research frontiers.

Conclusions

This bibliometric study highlights the growing interest in breast cancer-related lymphedema research and identifies key areas for future investigation, including prevention, diagnosis, and treatment strategies. The results underscore the need for further exploration of these emerging research areas to improve patient outcomes.
Pain science education concepts for pelvic pain: an e-Delphi of expert clinicians
Authors: Mardon Amelia K. , Leake Hayley B. , Wilson Monique V. , Karran Emma L. , Parker Romy , Malani Rinkle , Moseley G. Lorimer , Chalmers K. Jane
Published: February 2025

Introduction

Persistent pelvic pain is a prevalent condition that negatively impacts one's physical, psychological, social, and sexual wellbeing. Pain science education (PSE) involves learning about the biology of pain and is commonly integrated into the management of persistent pain. However, PSE is yet to be thoroughly investigated for persistent pelvic pain potentially due to the lack of targeted curricula, including learning concepts. The aim of this study was to gain consensus on PSE learning concepts important for persistent pelvic pain according to expert clinicians.

Methods

A three-round e-Delphi survey was conducted to generate and gain consensus on important PSE learning concepts for female persistent pelvic pain among 20 international, multidisciplinary expert clinicians (e.g., physiotherapists, gynaecologists, psychologists). Learning concepts generated by clinicians were rated by importance using a six-point Likert scale. Consensus on importance rating was considered reached for items with an IQR <1.0.

Results

The expert clinicians generated 125 PSE learning concepts that were considered important for persistent pelvic pain; 92 (73.6%) learning concepts reached consensus on their importance rating. Of the 125 learning concepts, 102 were generated for persistent pelvic pain in general, and were categorised into 13 overarching PSE concepts (e.g., persistent pelvic pain involves changes to the brain and nervous system). Sixteen PSE concepts were generated for specific pelvic pain conditions (e.g., endometriosis) and seven concepts for specific life stages (e.g., adolescence).

Discussion

This study provides the first list of key PSE concepts tailored for persistent pelvic pain developed by expert clinicians. These concepts provide a framework for developing and implementing PSE curricula for persistent pelvic pain in research and clinical settings.
TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response
Authors: Qi Juntao , Zhou Mingming , Yang Na , Ma Huiyun , He Min , Wu Gujie , Ge Chang , Jin Liuyin , Cheng Lin , Liao Wei , Ren Hefei , Lei Caiyun
Published: February 2025

Background: Tubulin alpha 1b (TUBA1B) is a key microtubule protein essential for maintaining cellular structure and function. This protein contributes significantly to cytoskeletal formation and is implicated in various diseases. Despite its fundamental roles, TUBA1B’s impact on tumor prognosis and the tumor immune microenvironment across cancer types remains inadequately understood.

Methods To elucidate TUBA1B’s role in cancer prognosis and immune response, we conducted a comprehensive analysis, integrating data from established databases such as The Cancer Genome Atlas, Genotype Tissue Expression, Cancer Cell Lineage Encyclopedia, Human Protein Atlas, Kaplan-Meier Plotter, cBioPortal, TIMER, and ImmuCellAI, along with a large-scale clinical study and immunotherapy cohort. We also conducted in vitro functional assays to assess TUBA1B’s functional role in tumor cells, allowing for a detailed examination of its relationship with cancer prognosis and immune modulation.

Results: Our findings indicate that TUBA1B expression is dysregulated across multiple cancers, correlating strongly with poor survival outcomes and advanced pathological stages. Functional enrichment analyses further revealed that TUBA1B regulates key cell cycle processes, driving tumor proliferation, migration, and invasion. It also influences immune functions within both the innate and adaptive immune systems, affecting immune-related signaling pathways. These insights underscore TUBA1B’s multifaceted role in cancer progression and immune response.

Conclusion: This study highlights TUBA1B’s potential as a human oncogene with substantial roles in tumorigenesis and immune regulation. Elevated TUBA1B levels are associated with an immunosuppressive tumor microenvironment, impacting cancer progression and treatment outcomes. Targeting TUBA1B may offer promising therapeutic avenues for enhancing cancer treatment, offering new perspectives for innovative anti-tumor strategies with high clinical impact.
Impact of fluoxetine exposure on Lymnaea stagnalis and its developing eggs: integrating untargeted lipidomics, targeted metabolomics, and classical risk assessment
Authors: Ilyaskina Diana , Nakadera Yumi , Lamoree Marja H. , Koene Joris M. , Leonards Pim E. G.
Published: February 2025

Pharmaceuticals such as selective serotonin reuptake inhibitors (SSRIs), are increasingly detected in aquatic environments, posing potential risks to non-target organisms, because many of those substances are widely shared neuromodulator. In this study, we investigated the effects of SSRI antidepressant, namely, fluoxetine, exposure on the freshwater snail L. stagnalis, focusing on egg development, neurochemical pathways, and lipid metabolism. Snails were exposed to a range of 51–434 µg fluoxetine L⁻1 for 7 days, followed by analysis of survival, feeding behaviour, reproduction, and metabolomic changes in the central nervous system (CNS), albumen gland, and eggs. Although no significant effects were observed on survival or fecundity, fluoxetine exposure significantly impaired egg development in a dose-dependent manner, reducing hatching rates with an EC50 of 126 µg fluoxetine L⁻1. Removal of eggs from the contaminated environment partially reversed these developmental effects, suggesting potential recovery if fluoxetine levels decrease. Molecular analysis revealed several neurochemical and lipidomic alterations. In the CNS, elevated levels of catecholamines, phosphatidylcholines (PC), and ceramides were linked to disruptions in neurotransmission, membrane integrity, and impaired embryo development. In the albumen gland, we detected a decrease of key lipid classes, including sphingomyelins and fatty acids, which can be linked with impaired egg quality. Additionally, a decrease in histamine in both the albumen gland and eggs suggested further disruption of egg development, potentially affecting metamorphosis success. Moreover, the dose-dependent increase in choline, along with PC and oxidized PC, indicated oxidative stress and lipid peroxidation in the CNS and exposed eggs of Lymnaea stagnalis. Our findings highlight the benefits of combining behavioral assessments with metabolomic profiling to better understand the mechanistic pathways underlying fluoxetine’s adverse effects.
Field measurement of atmospheric CO₂ column abundance based on portable laser heterodyne radiometer
Authors: Wang Yong , Zhang Maolei , Wang Jiapeng , Wang Gang , Cui Ruyue , Dong Lei , Wu Hongpeng
Published: February 2025

This study presents a portable near-infrared laser heterodyne radiometer specifically designed for measuring the column abundance of atmospheric carbon dioxide (CO₂) in the Taiyuan area. The instrument modulates the solar radiation using a fiber optic switch and amplifies the solar radiation through a semiconductor optical amplifier. The local oscillator laser is progressively scanned at the strong absorption characteristic of 1572.02 nm. Two beams of light are mixed on the photodetector to produce a heterodyne signal. To enhance performance, the radio frequency (RF) circuit system of the radiometer was thoroughly optimized, including adjustments to the filter bandwidth and the integration time of the lock-in amplifier. These improvements significantly enhanced the spectral signal-to-noise ratio (SNR) to a high level of 130 and achieved a spectral resolution of 0.0083 cm⁻1. The laser heterodyne signals were demodulated using a lock-in amplifier. Furthermore, a forward model based on line-by-line integration and an iterative fitting algorithm were employed to achieve high-precision CO₂ column abundance calculations. Outdoor field measurements conducted at Shanxi University validated the feasibility and practicality of this approach, laying a solid foundation for its broader application.
Identification and management of a novel Danshen leaf anthracnose caused by Colletotrichum karstii in Salvia miltiorrhiza Bunge in China
Authors: Ma Haoyue , Huang Liguo , Guo Lulu , Chen Shan , Liu Jiale , Liu Changyun , Dou Yanxia , Sun Xianchao , He Lin , Ma Guanhua
Published: February 2025

Danshen (Salvia miltiorrhiza Bunge), a member of the genus Salvia within the Lamiaceae family, holds significant economic and medicinal value. Regrettably, the emergence of a novel leaf anthracnose in 2020 has significantly impacted its cultivation, leading to decreased yield and compromised quality. This newly identified pathogen was meticulously isolated from affected leaves, employing meticulous single conidia isolation techniques. Subsequent confirmation of pathogenicity was achieved through strict adherence of Koch’s postulates. To ensure precise identification, morphological characteristics were supplemented with tandem sequence analysis targeting the rDNA internal transcribed spacer (ITS), β-tubulin (TUB), and histone (His3) regions. Combining molecular biology techniques with morphological observation and Koch’s postulates, the pathogen was conclusively identified as Colletotrichum karstii. Further investigations focused on understanding the environmental factors influencing the mycelial growth and sporulation of the pathogen. The optimum temperature for the growth of C.karstii is 25°C, the suitable light conditions are 12h light/12h dark or 24h dark, and the suitable pH is 5 to 9. Utilizing BIOLOG phenotypic analysis technique, the metabolic utilization of carbon and nitrogen sources by the pathogen was assessed across different temperatures (20°C, 25°C, and 30°C). Results indicated the highest utilization rates at 25°C, particularly for arbutin and L-tryptophan. Lastly, the efficacy of 15 chemical fungicides and six botanical fungiticide against C. karstii was evaluated in vitro, revealing fluazinam as the most potent inhibitor against mycelial growth with EC50 of 0.0725 mg/mL for mycelium and 0.0378 mg/mL for spore germination, respectively. The 1 % osthole emulsion in water was found to have the strongest inhibitory effect on the growth of mycelium, with an EC50 value of 4.8984 µg/mL. Spore germination was most strongly inhibited by the 80 % ethylicin EC, which had an EC50 value of 0.5541 µg/mL. This study represents the first documentation of C. karstii as a causative agent of anthrax in Danshen, underscoring the significance of these findings for agricultural management and disease control strategies.
Unconscious processing of happy faces correlates with prosocial tendency but not extraversion
Authors: Xu Qian
Published: February 2025

Perceiving facial expressions plays a crucial role in face-to-face social interactions. A wealth of studies has revealed the unconscious processing of emotional stimuli, including facial expressions. However, the relationship between the unconscious processing of happy faces and socially oriented personality traits—such as extraversion and prosocial tendency—remains largely unexplored. By pairing backward-masked faces with supraliminally presented faces in both visual fields, we found that the discrimination of visible emotional faces was modulated by the facial expressions of the invisible faces in the opposite visual field. The emotionally consistent condition showed a shorter reaction time (Exp 1) or higher accuracy (Exp 2) than the inconsistent condition. Moreover, the unconscious processing of happy faces was positively correlated with prosocial tendency but not with extraversion personality. These findings shed new light on the adaptive functions of unconscious emotional face processing, and highlight the importance of future investigations into the unconscious processing of extrafoveal happy expression.
Parental singing during kangaroo care: parents' experiences of singing to their preterm infant in the NICU
Authors: Hugoson Pernilla , Haslbeck Friederike Barbara , Ådén Ulrika , Eulau Louise
Published: February 2025

Introduction

Singing fosters emotional connections, attachment, bonding, and language development in infants. Prematurely born infants, however, are at risk of missing this vital communication, impacting neurodevelopment and family wellbeing, especially during prolonged hospital stays. Kangaroo care provides physiological and emotional support, while Creative Music Therapy (CMT) has demonstrated positive effects on neurodevelopment, parental wellbeing, and attachment. The Singing Kangaroo project, a Swedish-Finnish multi-center randomized controlled trial (RCT), investigated the impact of parental singing during kangaroo care. This qualitative follow-up study explores these findings through the lens of Antonovsky's Sense of Coherence (SOC) model.

Method

Semi-structured interviews were conducted with 28 families (20 intervention group, eight control group) at their infant's 5-month corrected age. The intervention group received CMT twice weekly during kangaroo care for 4 weeks in the NICU, while the control group received standard care. Data were analyzed inductively, followed by deductive categorization within the SOC framework, focusing on its three core components: Manageability, Comprehensibility, and Meaningfulness.

Results

Parents in the intervention group reported enhanced understanding of how singing fosters attachment and boosts their self-esteem, aligning with increased manageability and comprehensibility. Control group parents also experienced joy in singing, which positively influenced family wellbeing, albeit less extensively. Across both groups, singing was described as a meaningful activity that strengthened parent-infant bonding and promoted emotional connection within the family.

Conclusion

Parental singing during kangaroo care, particularly when supported by a trained music therapist, enhances parents' sense of coherence by fostering comprehensibility, manageability, and meaningfulness. This study highlights the long-term benefits of integrating CMT into family-centered NICU care to support both infants' neurodevelopment and family wellbeing.
User avoidance behavior in pharmaceutical e-commerce intelligent customer service: a stressor-strain-outcome perspective
Authors: Jia Jing , Chen Lu , Wu Chengzhen , Xiao Manling
Published: February 2025

Introduction

This study explores the implementation of Intelligent Customer Service (ICS) in pharmaceutical e-commerce, aiming to enhance user acceptance and service efficiency while addressing the psychological factors influencing user behavior. It expands the boundaries of technology acceptance research by focusing on ICS use and avoidance in high-risk environments.

Method

A total of 418 valid questionnaires were collected from participants, ensuring data quality through rigorous screening. The study employed SPSS for data normality tests and SmartPLS for structural equation modeling to analyze the relationships between emotional stress, system overload, and user avoidance behavior.

Results

The findings indicate that system overload, information overload, and service overload significantly contribute to user emotional stress, which in turn drives avoidance behavior. The analysis revealed strong explanatory power (R2 values ranging from 0.450 to 0.586) and confirmed the mediating role of emotional stress in the relationship between overload factors and user avoidance.

Discussion

This research highlights the critical role of emotional stress in user interactions with ICS, suggesting that pharmaceutical e-commerce companies must refine their ICS design to meet diverse user needs and reduce cognitive burdens. By leveraging big data and establishing robust feedback mechanisms, companies can enhance user experience and loyalty. The study also identifies limitations in demographic representation and suggests future research should incorporate qualitative methods for a deeper understanding of user behavior.
Association between weekend catch-up sleep and hypertension of the United States population from 2017 to 2020: a cross-sectional study
Authors: Luo Yan , Li Qingyuan , Feng Tong , Meng Shasha , Duan Ran
Published: February 2025

Background

Hypertension is a prevalent cardiovascular risk factor that significantly contributes to morbidity and mortality worldwide. Previous studies have highlighted the role of inadequate sleep during weekdays in the development of hypertension. However, the potential mitigative effects of weekend catch-up sleep (WCS) on hypertension have been less explored.

Methods

This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020, focusing on American adults. We assessed the association between WCS (defined as the difference in sleep duration between weekend and weekday) and the presence of hypertension. Participants were classified into two groups based on their WCS duration: none (below 1 hours), yes (over 1 hours). Multivariable logistic regression models adjusted for potential confounders such as age, gender, Body mass index (BMI), and lifestyle factors were utilized to explore this association. A Generalized Additive Model (GAM) was employed to generate smooth curves for a nuanced analysis of the nonlinear relationship.

Results

The findings indicated that moderate WCS (less than 4 hours) was significantly associated with a reduced risk of hypertension, while excessive WCS (greater than 4 hours) showed no significant protective benefits.

Conclusion

Moderate weekend catch-up sleep could serve as an effective intervention to mitigate hypertension risk, especially in populations with restricted weekday sleep. These results suggest the potential for integrating sleep management strategies into public health recommendations to address hypertension. Future longitudinal studies are needed to confirm these findings and clarify the mechanisms underlying the relationship between WCS and hypertension risk.
Network analysis of interactions of rumination and anxiety on smartphone dependence symptoms
Authors: Zhang Sen sen , Yong Shao hong , Chen Jia tai
Published: February 2025

Objective

Rumination and anxiety have been posited as correlates of smartphone dependence (SPD). However, little is known regarding how the components of both affect SPD symptoms at subtle levels. Therefore, we used the network analysis approach to identify the connections at a micro level to provide possible interventions for reducing SPD symptoms.

Methods

Using symptom-level network analysis, we used the ruminative response scale-10, the generalized anxiety disorder scale-7, and the mobile phone addiction index scale-17 to investigate Chinese preservice teachers (Mage = 21.1, N = 1160). Subsequently, we estimated a graphical lasso correlation network for these teachers, which encompassed rumination components, anxiety components, and SPD symptoms. Specifically, the central and bridge centralities within the network structure were examined for the impacts of rumination and anxiety on SPD symptoms.

Results

The three intracluster connections of rumination, anxiety, and SPD were tighter than the intercluster, with structural connections in rumination and anxiety networks closer than the triggered SPD symptoms cluster. Importantly, reflection reactions towards “write down what you are thinking and analyze it” (a component of rumination) were identified as a central and bridging node that might be a target for intervention for SPD symptoms.

Conclusion

We identify potential edge-bridging rumination and anxiety on SPD and locate highly central components within each cluster via network analysis.
Network analysis of meaning in life, perceived social support, and depressive symptoms among vocational undergraduate students
Authors: Zhang Sen sen , Zhang Wen hua , Yong Shao hong , Chen Jia tai
Published: February 2025

Background

Depression poses a considerable personal and public health problem, particularly in the post-epidemic era. The present study aimed to investigate the association between meaning in life (MIL) and perceived social support (PSS) with depressive symptoms among vocational undergraduate students, employing a network analysis approach to gain a deeper understanding of the underlying pathways and to prevent the progression of depressive symptoms into disorders.

Methods

A total of 1367 Chinese vocational undergraduates (Mage = 20.1, SD = 1.6; 44.7% female) were recruited and were asked to complete a series of questionnaires, including the meaning in life questionnaire, perceived social support scale, and patient health questionnaire. The regularized partial correlation network was estimated. The partial correlations between nodes were calculated as edges. Moreover, network comparison tests were conducted to compare three subnetworks based on different levels of depression (minimal, subthreshold, and moderate/severe).

Results

The top strength nodes within each network were identified as sleep and motor in minimal group, anhedonia and concentration in subthreshold group, and anhedonia and sleep in moderate/severe group. Additionally, the bridge strength nodes were determined as MIL-3, MIL-4, sleep, guilt, and school in minimal group; MIL-4, anhedonia, suicide, and friend in subthreshold group; MIL-9, MIL-7, anhedonia, sleep, and family in moderate/severe group. Furthermore, network comparison tests showed significant differences in centrality (all p < 0.05), while network invariance remained constant across groups. Notably, the accuracy and stability coefficients for all network structures were greater than 0.5, indicating stable and reliable results.

Conclusion

These findings elucidate specific pathways and potential central nodes for interactions of MIL or PSS with depressive symptoms at different levels of depression, providing valuable insights for targeted prevention and intervention strategies.
The relationship between smartphone addiction and sleep disorder among college students: negative emotions as a mediator and gender as a moderator
Authors: Li Siyi , Deng Yingying , Cai Lihong , Wu Linlin
Published: February 2025

Background

College students are disproportionately affected by smartphone addiction, which has been linked to various health impairments, including sleep disorders. This study explores the relationship between smartphone addiction and sleep disorders, with a focus on negative emotions as a mediator and gender as a moderator.

Methods

Cluster sampling was used to survey 1056 Chinese college students. The Mobile Phone Addiction Index, Negative Affect Scale, and Sleep Disorder Scale were administered. Versions of SPSS 27.0 and PROCESS macro 4.0 were used for data analysis, employing Models 15 and 4 to examine moderation and mediation, respectively.

Results

A strong direct correlation was identified between smartphone addiction and sleep disorder, with negative emotions mediating this relationship, accounting for 33.7% of the effect. Gender significantly moderated the mediation process, with females demonstrating a greater correlation than males between sleep disorders and negative emotions.

Conclusion

Negative emotions partially mediated smartphone addiction’s association with sleep disorder, whereas gender significantly moderated this mediation. These findings underscore the complex dynamics among smartphone addiction, emotional well-being, and sleep among college students.
The 4E theory-based performance benchmarking of aged care service provision in community care facilities: a case study of Nanjing, China
Authors: Huang Wei , Hu Ying , Li Lingzhi , Wang Chendi , Liu Luyao
Published: February 2025

The global aging population is growing rapidly, and due to its large population, China is expected to become a ‘super-aged society’ within the next decade. Therefore, ensuring that older people can ‘age in place’ has become a major national priority. Community-care facilities (CCFs) play a key role in this process, but their service performance often faces challenges, with high input costs and limited output benefits. This paper aims to evaluate and improve the social and economic performance of CCFs by proposing a comprehensive framework based on the 4E (Economy, Efficiency, Effectiveness, Equity) theory. Specifically, based on the 4E theory, a literature review and correlation analysis are conducted to select performance indicators. The input–output relationships are then established according to the four dimensions of the 4E theory. These indicators and input–output relationships form the foundation for applying the δ-SBM DEA model, which is used to assess the performance of 75 CCFs in Nanjing. The study finds that the economic performance of CCFs generally lags behind their social performance, with many facilities showing inefficiency in economic indicators, characterized by high operational costs and limited profitability. Projection analysis reveals major issues in low-performing CCFs, including uneven regional distribution of facility performance, poor profitability, a shortage of skilled older people care professionals, and insufficient older people’s participation. Based on these findings, the paper provides specific policy recommendations for government authorities, industry associations, and CCFs, focusing on improving cost-effectiveness, increasing the number of professionals, and enhancing older people’s participation.
The analysis of factors influencing patient choice of healthcare providers between tertiary hospitals and community clinics
Authors: Wu Silin , Lei Zhaoxia , Liu Tinglian , Chen Lan , Qin Yang
Published: February 2025

Background

The uneven distribution of medical resources in China has led to persistently low utilization rates of primary healthcare institutions. The tiered healthcare delivery system aims to optimize resource allocation and strengthen primary care, yet patient preferences for tertiary hospitals hinder its effective implementation. Understanding the factors influencing healthcare-seeking behaviors is crucial for improving policies and promoting system efficiency.

Objective

To analyse the factors influencing patient choices between a tertiary hospital and a community health service center in Chengdu and provide recommendations for advancing the tiered healthcare system.

Methods

A random sampling method was used in August 2023 to survey patients at a tertiary hospital (Group A) and a community health service center (Group B). The survey assessed demographics, health status, factors influencing provider choice, and awareness of the family doctor system. Chi-square, t-tests, or Wilcoxon rank-sum tests were used for group comparisons, while logistic regression identified factors associated with primary care visits.

Results

Among 865 valid responses (Group A: 420; Group B: 445; 92.02% response rate), Group A had significantly higher education levels and household incomes (p < 0.001), while Group B had higher chronic disease prevalence and family doctor contract rates (71.5% vs. 59.3, 44.5% vs. 25.5%; both p < 0.01). Positive factors for choosing community healthcare included better equipment and medication availability (46.9%), lower costs with higher reimbursement (45.0%), and convenient transport (41.2%). Negative factors included distrust in community care quality (39.1%) and limited familiarity with family doctors (32.8%). Logistic regression indicated that being over 60 years old (OR: 1.94, CI: 1.02–3.69) and awareness of the tiered healthcare system (OR: 2.48, CI: 1.56–3.96) were significant factors for seeking primary care.

Conclusion

Patients with higher education and income prefer tertiary hospitals, while chronic disease patients are more likely to utilize community care. Low family doctor contract rates and trust in community healthcare quality remain barriers. Strengthening community resources and promoting the tiered healthcare system could improve patient participation and alleviate pressure on tertiary hospitals.
Informed consent in dementia research: how Public Involvement can contribute to addressing “old” and “new” challenges
Authors: Diaz Ana , Birck Cindy , Bradshaw Angela , Georges Jean , Lamirel Daphne , Moradi-Bachiller Soraya , Gove Dianne
Published: February 2025

Informed consent is a critical ethical requirement in research, ensuring the protection of participants' rights and promoting their wellbeing and autonomy. In dementia research, this process becomes particularly complex due to cognitive impairments and fluctuating capacity. While substantial work has been done to address these challenges, much of the literature on informed consent in dementia research has been shaped by the perspectives of researchers and healthcare professionals, with less focus on those with lived experience. This paper provides an overview of the perspectives of people with dementia and their carers resulting from Public Involvement activities organized by Alzheimer Europe. It builds on Alzheimer Europe's previous work with the European Working Group of People with Dementia and draws on discussions held during a face-to-face meeting about Participant Informed Consent forms and processes used in two specific European projects. We highlight views and key concerns raised by people with lived experience regarding the informed consent process, including barriers and facilitators. In addition to ensuring understandability, the discussions emphasized the importance of promoting respect and autonomy, ensuring that the values and interests of people with lived experience remain central throughout the research process. This paper contributes to the ongoing dialogue on improving informed consent practices in dementia research, highlighting the need for continuous involvement and the inclusion of people with lived experience in shaping consent practices to address both old and emerging challenges (i.e., new types of research such as artificial intelligence and data sharing/re-use) in dementia research.
Changes and their effects on working and daily life time use allocation between work-from-home and office work days during the telework period: insights from the survey in Japan
Authors: Aoki Eri , Hiramatsu Ai , Hanaki Keisuke
Published: February 2025

Introduction

The rapid adoption of telework, accelerated by advancements in ICT and the COVID-19 pandemic, offers potential benefits for wellbeing and environmental impact. However, telework’s effects on work productivity, work-life balance, and social connectedness remain complex, particularly within hybrid models combining work-from-home (WFH) and in office days.

Methods

This study assessed telework’s impact by comparing WFH and office days. A survey of 1,500 full-time workers in Japan’s Tokyo Metropolitan Region focused on daily time allocation, and telework preferences during telework periods. Principal component and cluster analyses were used to identify groups with distinct work and lifestyle patterns.

Results

Six telework-related groups emerged, reflecting diverse experiences in productivity and daily life. Groups such as the “Overall Increase” and “Housework and Rest Increase” reported gains in leisure and family time, positively impacting wellbeing. In contrast, the “Unsuitable for WFH” group faced increased office-day workloads and reduced WFH productivity, indicating that telework’s effectiveness depends on job and individual characteristics.

Conclusion

The findings highlight telework’s potential to enhance wellbeing and sustainability but also underscore the need for tailored policies that address diverse job requirements and personal characteristics. This study contributes to sustainable telework strategies by offering insights into effective support systems that balance flexibility, productivity, and environmental sustainability, aiming both for an enhanced personal life and societal benefits.
40-years of relative age effects: life is not fair!
Authors: Barnsley Roger H.
Published: February 2025

This paper explores the Relative Age Effect (RAE) after nearly 40 years since its initial examination in sports. Two original studies identified significant participation differences between relatively older and younger players in age-grouped elite hockey and soccer. In the current study, we replicate the original analyses using 2023 data. By comparing data from the original studies and 2023, focusing on Major Junior A hockey in North America and the Under-17 and Under-20 World Soccer Tournaments, we observe remarkably similar RAE patterns. For instance, both the original and the 2023 studies indicate that about 40% of elite young adult players were born in the first quarter of the age cohort, compared to just 10% in the last quarter. This paper underscores the ongoing advantages and disadvantages created by RAE and calls for greater focus on strategies to mitigate its unfair effects in sports and education.
Case report: A study on the pathological diagnosis of oral fibrosarcoma in a giant panda
Authors: Xiong Zongliang , Ling Shanshan , Li Caiwu , Deng Linhua , He Ming , Wang Chengdong , Li Desheng , Chen Zhengli
Published: February 2025

A female giant panda presented with a large, hard mass on the right cheek, which was investigated at the Dujiangyan Base of the China Conservation and Research Center for the Giant Panda with computed tomography (CT) scans and biopsy of the oral mass, as well as venous blood sampling. Hematological tests revealed elevated levels of the tumor marker CA724, along with infectious disease, anemia, hepatic damage, and renal failure. Imaging studies identified a soft tissue mass in the right cheek area. Macroscopic pathological changes, histopathological features, and immunohistochemical analysis were consistent with a low-grade malignant fibrosarcoma within the oral cavity, indicating malignant potential. This case represents the first report of an oral tumor in a giant panda, providing valuable data for future clinical diagnoses of neoplasms in this species.