bluuebunny/crossref_metadata_2025 huggingface dataset:
USING E-LEARNING TO PREVENT INFORMATIONAL STRESS OF EMPLOYEES WORKING REMOTELY
Authors: Pinchuk Oleksandra , Pinchuk Nataliia I. , Bondarchuk Olena I. , Balakhtar Valentyna V. , Pavlenok Kateryna S.
Published: December 2023

The article deals with the problem of remotely working employees' informational stress caused by crisis conditions in Ukraine. The article analyzes the features of e-learning important for preventing informational stress among remotely working employees. The following specific features of informational stress, by their information impact, are highlighted: 1) features associated with information overload, 2) features associated with human interaction with information technology, and 3) features associated with professional activities.
The article presents the results of a comparative analysis of the psychological characteristics of employees with a conventional mode of remote work and the employees with a forced remote work mode due to crisis conditions (Covid-19, war, etc.).
Based on the results of the interview specially designed by the authors, the factors that, according to employees, contribute to the emergence and development of informational stress have been identified. It was found that informational stress has a complex negative impact on the life, work and social contacts of employees who work remotely. There are statistically significant differences in gender, age, organizational and professional factors in stress development between employees with a conventional mode of remote work and employees with a forced remote work mode due to crisis conditions (Covid-19, war, etc.).
The psychological principles and conditions of the enactment of e-learning, aimed at preventing informational stress among remotely working employees, have been determined. The authors present an e-training program aimed at preventing informational stress among remotely working employees. The stages of the program implementation are characterized and the most appropriate e-learning tools at each of these stages are indicated. According to the results of the approbation of the program, it was established that the e-learning program can be useful in the distance postgraduate education of specialists.
El libre desarrollo de la personalidad como derecho fundamental general de libertad-autonomía: la eutanasia y el aborto en las sentencias del Tribunal Constitucional 19/2023 y 44/2023
Authors: Sieira Mucientes Sara
Published: December 2023

Las Sentencias del Tribunal Constitucional 19/2023 y 44/2023 tienen un nexo común argumental que viene a constituir su principal ratio decidendi, consistente en la creación de un nuevo derecho fundamental de autodeterminación para decidir sobre la propia muerte y sobre la interrupción voluntaria del embarazo,que pasan a constituir nuevos derechos fundamentales a la eutanasia y al aborto, integrándolos en el derecho a la integridad física y moral (art. 15 CE), limitando así la libertad de configuración del legislador respecto de los mismos. El activismo judicial desplegado en esta operación no puede dejar de suscitar una gran perplejidad. El hasta ahora considerado «principio» de la dignidad de la persona y del libre desarrollo de la personalidad (art. 10.1 CE), en virtud de esta innovadora jurisprudencia, deja de operar como tal para convertirse, no ya en un «principio general de libertad», cuestión que distaría incluso de ser pacífica en la doctrina, sino en un verdadero «derecho fundamental general de libertad», en definitiva, como norma de clausura del sistema de libertades públicas. A diferencia de la regulación en derecho constitucional alemán, inspirador del Anteproyecto de la ponencia constitucional en España, en que el libre desarrollo de la personalidad constituye un derecho fundamental, también norma de clausura, con unos límites bien establecidos por la jurisprudencia del Tribunal de Karlsruhe, ni la dicción literal, ni la sistemática de la Constitución española permite una incorporación acrítica de la construcción alemana, ni su empleo por parte del Tribunal Constitucional español ha sido, en esta última jurisprudencia...
Aspectos documentales del control de subsidiariedad en España. La Comisión Mixta para la Unión Europea
Authors: Eizaguirre Massé María José
Published: December 2023

Conforme al principio de subsidiariedad, la Unión Europea solo intervendrá en los ámbitos que no sean de su competencia exclusiva, cuando los objetivos de una acción no puedan ser alcanzados de manera suficiente por los Estados miembros, ni a nivel central ni a nivel regional y local.

Mediante el sistema de «alerta temprana», los Parlamentos nacionales reciben las iniciativas legislativas europeas y pueden emitir un dictamen respecto al cumplimiento del principio de subsidiariedad. Reciben también los documentos que se van generando en la tramitación de dichas iniciativas a lo largo del procedimiento legislativo europeo y además otra gran cantidad de documentación en el marco del «diálogo político».

La recepción y tramitación de toda esta documentación, en España se han canalizado en la Comisión Mixta para la Unión Europea. Desde ahí se trasladan las iniciativas legislativas europeas a los Parlamentos de las comunidades autónomas, quienes a su vez pueden remitir un dictamen sobre el cumplimiento del principio de subsidiariedad. También el Gobierno remite informes al respecto, y las Cortes Generales pueden solicitarle la presentación de un recurso ante el Tribunal de Justicia de la UE por infracción del principio de subsidiariedad de la legislación europea.

La abundancia y diversidad de documentos en circulación, así como la variedad de autores y de plazos a los que está sujeta la actividad, producen una documentación compleja de manejar.

El artículo detalla el modo en que toda la documentación implicada en la actividad de control de subsidiariedad en las Cortes Generales se ha estructurado...
Bruxismo do sono e disfunção temporomandibular - uma análise da complexa relação e implicações para a saúde bucal
Authors: Morais Alice Caroline Odilon de , Silva Stephane Mariane Alcântara da , Oliveira Alexandre Henrique Moura de
Published: December 2023

Objetivo: Conduzir uma revisão integrativa sobre as relações entre bruxismo do sono e disfunção temporomandibular. Método: Realizou-se uma análise da literatura, utilizando artigos provenientes das bases de dados PubMed, Lilacs e Scielo, com foco na investigação de sintomas clínicos e dados eletromiográficos/eletrocardiográficos. Foram considerados artigos publicados em português e inglês, no período de 2017 a 2023, com os descritores "bruxismo", "disfunção temporomandibular" e "sintomas de DTM". Excluíram-se os artigos publicados em período inferior ao pré-estabelecido e aqueles que não abordavam a correlação entre bruxismo e disfunção temporomandibular. Resultados: A pesquisa revelou uma complexa relação entre bruxismo e disfunção temporomandibular (DTM), destacando implicações significativas para a saúde bucal. A análise indica que o bruxismo pode ser um fator contribuinte para o desenvolvimento e agravamento da DTM, sublinhando a importância da abordagem integrada no tratamento e na prevenção de problemas associados à saúde da articulação temporomandibular. Conclusão: Este estudo oferece contribuições significativas para a compreensão dos fatores associados ao bruxismo do sono e à disfunção temporomandibular, ressaltando a relevância contínua da pesquisa nesse campo.
Hamartoma hipotalâmico: Um caso raro de puberdade precoce central no sexo masculino
Authors: Almeida Ana Cecília Borges , Hernandes Sandra Regina Chahuan Tobji
Published: December 2023

Este trabalho teve por propósito, relatar um caso raro de um menino, com pouco mais de 2 anos de idade, histórico de convulsões gelásticas e sinais de puberdade precoce. O paciente, com 1 ano e 8 meses de idade, apresentou pelos pubianos, aumento do tamanho peniano, testicular e surgimento de acnes. Somado a isto, a criança manifestava crises de risos desmotivados (convulsões gelásticas) e alteração comportamental, como agressividade diariamente.  No exame de Ressonância Nuclear Magnética da hipófise observou-se uma lesão expansiva em região hipotalâmica com parcial obliteração do aspecto posterior da cisterna suprasselar e cisterna interpeduncular, compatível com hamartoma hipotalâmico. Deu-se início ao tratamento, com o análogo do GnRH e carbamazepina. O paciente aqui relatado, segue em tratamento farmacológico.
Raro caso de infecção por paracoccidioidomicose em uma criança no estado de Mato Grosso do Sul: Um relato de caso
Authors: Cordera Ana Carolina , Alexandre Alecsander Silva de
Published: December 2023

Introdução: A paracoccidioidomicose é uma infecção fúngica de forma sistêmica causada pelos fungos Paracoccidioides brasiliensis (P. brasiliensis) e Paracoccidioides lutzii (P. lutzii), os quais habitam como hospedeiros definitivos em tatus, cães e seres humano. É adquirido através da manipulação de solo ou detritos contaminados, adentrando pela via inalatória e atingindo de forma sistêmica múltiplos órgãos – sendo de raro acometimento pediátrico. Objetivo: Relatar um caso clínico pediátrico de paracoccidioidomicose no departamento de cuidados de terapia intensiva pediátrica do Hospital Universitário Maria Aparecida Pedrossian (HUMAP).  Metodologia:  Estudo observacional, descritivo, narrativo e reflexivo, tipo relato de caso clínico. O dados gerais foram obtidos através do prontuário médico eletrônico, após aprovação do Comitê de Ética em Pesquisa. Resultados: Paciente, sexo masculino, 6 anos, com quadro crônico de febre diária associada a vômitos pós prandiais, diarreia, hiporexia, fraqueza, perda ponderal, aumento de volume abdominal e acometimento pulmonar. Foi encaminhado ao serviço de infectologia pediátrica no HUMAP, onde foi diagnosticaso com paracoccidioidomicose. Paciente foi tratado com Anfotericina B lipossomal evoluindo com melhora clínica e possibilitando alta médica com retorno ambulatorial. Apesar do paciente não ter ser da faixa etária comumente acometida, o mesmo apresentou história positiva de exposição rural e sintomas clínicos altamente sugestivos. O caso teve múltiplas correlações com a revisão bibliográfica realizada, comprovando que o serviço realizou condutas corretamente. Conclusão: Conclui-se que é necessário conhecer a doença para investigar a mesma dentro das doenças infectocontagiosas, bem como a importância do registro de casos para organização de políticas públicas adequadas.
Длительный мониторинг деформаций железобетонных конструкций методом ключевых точек
Authors: АРЛЕНИНОВ Пётр Дмитриевич , ТРОФИМОВ Сергей Владиславович
Published: December 2023

Мониторинг текущего технического состояния несущих конструкций - одна из важнейших задач на всех этапах жизненного цикла технически сложных и уникальных зданий и сооружений. Цель исследования - разработка комплексной системы мониторинга, позволяющей определять взаимные деформации двух рядом расположенных конструкций в пространстве в трех направлениях на основе ключевых точек, а также установление взаимных перемещений температурно-деформационных блоков друг относительно друга (горизонтальные и вертикальные перемещения, наклон, поворот, крен). Такая система была разработана, спроектирована, изготовлена, смонтирована и апробирована на одном из эксплуатируемых промышленных зданий, на котором проводились мониторинговые работы (показания снимались в течение года). При анализе полученных данных были отмечены следующие преимущества разработанной системы относительно других методов мониторинга: возможность выполнения контрольных измерений в стесненных условиях, отсутствие потребности в дорогостоящем оборудовании при выполнении работ по монтажу и эксплуатации, точность измерений, минимальные разбросы в получаемых значениях, устойчивость к вандализму.
ENHANCEMENT OF BRAND LOVE RESONANCE CAPABILITIES ON DESTINATION LOYALTY: S-DL PERSPECTIVE
Authors: Roymon Panjaitan  , Arif Afendi  , Elia Ardyan
Published: December 2023

The emergence of inconsistencies in study findings regarding destination brands does not contribute to an increase in customer loyalty toward tourist destinations. Furthermore, exploring the capacity to expand affection for the brand is a meaningful topic within the tourism business phenomenon. Therefore, it is crucial to examine how well the tourism business can reflect the affection for the destination brand. This study aimed to explore and develop the conceptual and empirical relationship between brand authenticity and destination loyalty. To conduct the analysis, a quantitative method was selected, using a sample of 297 respondents in Central Java, Indonesia. The data collected from distributing questionnaires were then processed using SEM-PLS software. Furthermore, the study was grounded in the Service-Dominant Logic perspective and focused on operant resources with the potential to enhance the value of natural destinations by capturing the emotional resonance of the destination brand. The results showed that loyalty goals were empirically and practically increased by creating a context-based model and leveraging the capability of brand love resonance. The approach addressed the gaps in prior studies and provided tourism actors with the means to consider external characteristics.
DOES PERFORMANCE IMPROVE SUSTAINABILITY? EMPIRICAL RESEARCH ON INDONESIAN MSMEs
Authors: Dekeng Setyo Budiarto  , Muhammad Agung Prabowo  , Tri Nur Kartika
Published: December 2023

Micro, Small, and Medium Enterprises (MSMEs) are business sectors known to play an essential role in the economic growth of a country, especially in Indonesia. In this context, the creative industry is one of the fastest-growing business sectors and the promotion of sustainable economic development is evident in the government's active support for improving the growth of MSMEs. Therefore, this study analyzes the impact of financial literacy and market orientation on the MSMEs performance and sustainability. The sample includes 95 respondents occupying the roles of owners or managers in the creative industry of Yogyakarta Province. The results show that financial literacy and market orientation positively impact performance and sustainability. The performance of MSMEs influences business sustainability but financial literacy has no significant impact. Therefore, the implications show the indispensable need for governmental assistance in improving the knowledge base of MSMEs owners concerning financial literacy and market orientation.
A History of the Fort at Long Akah: Contact, Collaboration and Power
Authors: Mashman Valerie
Published: December 2023

This paper traces history through the fort at Long Akah during the various eras of the Brooke administration, the colonial government and the Sarawak State government. This study takes its cue from the notion of the fort as a vehicle for a distinctive history of an area and uses indigenous oral histories and recollections as “alternative history.” Forts were built during and after pacification and this process was dependent on the collaboration of local leaders whose influence was ritually prescribed by the adat. The forts functioned as a place where taxes were paid, where court cases were heard, and where trading took place. While the fort at Long Akah represented locally a locus of power for the Brooke administration, it will be seen that this power was located in a crucial local collaboration in governance, which depended on the role of local leaders.
Strategi dan Taktik Marketing Communication Bank Danamon dalam Meningkatkan Brand Awareness
Authors: Nadia Calista  , Hana Haifa Rahma  , Alyssa Rasheedah Cahaya Bintang
Published: December 2023

Seiring berkembangnya waktu, pertumbuhan berbagai sektor industri di Indonesia semakin pesat. Salah satu sektor industri tersebut adalah perbankan. Marketing public relations merupakan sebuah divisi yang berfungsi sebagai pembuat dan pengatur strategi dalam menjalankan taktik - taktik nya guna membuat perusahaan dan produknya mendapatkan reputasi baik yang nantinya akan menstimulasi pendapatan laba perusahaan. Pada Bank Danamon, marketing public relations dinamakan marketing communication dengan tugas dan fungsi yang serupa. Tujuan dari penelitian ini adalah untuk mengetahui strategi dan taktik yang dijalankan oleh divisi marketing communication Bank Danamon dalam menjalankan tugas dan fungsinya. Metode penelitian ini adalah kualitatif Dalam hal ini peneliti meneliti aktivitas marketing public relations di perusahaan Bank Danamon. Teknik pengumpulan data dilakukan melalui wawancara secara langsung yang dilakukan secara terstruktur. Selain itu, peneliti juga menggunakan sumber data sekunder lainnya dengan meninjau website milik Bank Danamon. Hasil penelitian dapat diketahui bahwa Bank Danamon menggunakan strategi pull,push, dan pass. Selain penggunaan ketiga strategi tersebut, Danamon juga menggunakan strategi 360 degree. Dimana strategi ini dibuat untuk dapat melakukan kegiatan marketing communication secara holistik. Taktik yang digunakan adalah campaign, event, dan social media activation dan CSR.
Classification method of surrounding rock of plateau tunnel based on BP neural network
Authors: Shuguang Li , Yanjun Shen , Peng Lin , Jiangsheng Xie , Sisi Tian , You Lv , Wen Ma
Published: December 2023

Due to the unique high-altitude geological conditions of the railway in the cold region, the problem of high ground stress in the construction process is very prominent. In constructing high ground stress tunnels, accurately evaluating the surrounding rock grades is important in rock mass engineering. Based on this, based on a plateau tunnel under construction, this paper selects the classification index of the surrounding rock, which can accurately reflect the geological characteristics of high ground stress tunnel around the geological environment elements of the surrounding rock of high ground stress tunnel. Based on the rapid classification method of surrounding rock of the BP neural network, the classification method of the surrounding rock suitable for high ground stress tunnel is constructed, and the tunnel engineering data is introduced into the BP neural network classification method of surrounding rock for training and testing. It is found that the classification results of surrounding rock obtained by the classification method of surrounding rock of high ground stress tunnel are in good agreement with the actual situation, which provides an important guarantee for the accurate and rapid determination of the surrounding rock grade of high ground stress tunnel and the safe and efficient construction of the tunnel.
Failure mechanisms and dynamic process control measures of deep buried tunnels in tectonic fracture zones under high in-situ stresses—a case study in Southwestern China
Authors: Zheng Keyue , Shi Chenghua , Zhao Qianjin , Lei Mingfeng , Jia Chaojun , Lou Yili
Published: December 2023

Squeezing deformation in tectonic fracture zones under high in-situ stresses has created great difficulties to deep tunnel construction in Southwestern China. This study reports an investigation on large deformation and failure mechanisms of the Wanhe tunnel on the China-Laos Railway through several field tests including the in-situ stress, loosened zone, deformation monitoring, and internal stresses of steel arches. The dynamic process control method is proposed following the combination principle of stress releasing and support resistance. Further, the dynamic process control measures including the advanced and primary supports, the deep-shallow coupled delayed grouting method, and the double steel arches method were applied on site to resist the deformation development. The results of this study indicate that the rapid growth of the tunnel deformation in the early stage was caused by the squeezing effect, and later the loosening effect led to another growing trend of the vault settlement. The dynamic process control method allows to release the deformation of the surrounding rock in the rapid growth stage. Then, it requires to control the deformation within the reserved range by reinforcing the surrounding rock and increasing the stiffness of supports in the later stage. From the feedback of monitoring results, large deformation of Wanhe tunnel was well released and effectively controlled within the deformation allowance. Thus these countermeasures based on the dynamic process control method can guarantee the construction safety of deep buried tunnels in tectonic fracture zones under high in-situ stresses.
Coastal upwelling and redox variations in the northwestern Tarim Basin (northwest China) during the Middle-Late Ordovician: implication for paleo-depositional conditions of the organic matter enrichment in the Saergan Formation
Authors: Zhu Bi , Guo Tingting , Liu Chenhui , Pan Wenqing , Chen Yongquan , Zhang Yinggang , Yang Tao
Published: December 2023

The black shales of the Saergan Formation, which represent one of the main hydrocarbon source rocks in the Tarim Basin, witnessed a time span of organic matter enrichment by profound changes in the Earth System. A multi-proxy geochemistry study was carried out on the samples of the Saergan Formation to reconstruct the depositional environment and to explore the mechanism of organic matter enrichment of the unit at the Yingshanbeipo section, Keping area, northwest Tarim. Elemental and TOC data are suggestive of an upwelling setting, with a less pronounced oxygen minimum zone (OMZ) compared to the highly productive Peru and Namibian margins. Ferruginous anoxic bottom water conditions prevailed during most time of the deposition, with suboxic conditions dominating the basal and the top parts of the studied unit. As a whole, primary productivity seems to be the dominating factor that controlled the micronutrients and OM accumulations in the Saergan Formation whereas the role of benthic redox conditions may have been subordinate. The variations in primary productivity and bottom water redox conditions were resulted by the multiple, interacting environmental factors including nutrient supply regulated by oceanic circulation and climate changes, and relative sea-level fluctuations.
Operating characteristics analysis and capacity configuration optimization of wind-solar-hydrogen hybrid multi-energy complementary system
Authors: Su Wei , Li Qi , Wang Shuoshuo , Zheng Wenjin , Bai Zhang , Han Yunyi , Yu Zhenyue
Published: December 2023

Wind and solar energy are the important renewable energy sources, while their inherent natures of random and intermittent also exert negative effect on the electrical grid connection. As one of multiple energy complementary route by adopting the electrolysis technology, the wind-solar-hydrogen hybrid system contributes to improving green power utilization and reducing its fluctuation. Therefore, the moving average method and the hybrid energy storage module are proposed, which can smooth the wind-solar power generation and enhance the system energy management. Moreover, the optimization of system capacity configuration and the sensitive analysis are implemented by the MATLAB program platform. The results indicate that the 10-min grid-connected volatility is reduced by 38.7% based on the smoothing strategy, and the internal investment return rate can reach 13.67% when the electricity price is 0.04 $/kWh. In addition, the annual coordinated power and cycle proportion of the hybrid energy storage module are 80.5% and 90%, respectively. The developed hybrid energy storage module can well meet the annual coordination requirements, and has lower levelized cost of electricity. This method provides reasonable reference for designing and optimizing the wind-solar-hydrogen complementary system.
Incremental feedforward collective pitch control method for wind turbines
Authors: Wang Qinwei , Du Zeli , Chen Wenting , Zhang Jiarui , Lin Yonggang , Liu Hongwei
Published: December 2023

In recent years, wind turbines are becoming larger, which will exacerbate the complexity of loads Complex load change affect the output power quality and wind turbine service life so that must be studied. Pitch control is usually used to reduce wind turbine load. In this paper, based on the Light Detection and Ranging (LiDAR) technology and incremental feedforward control theory, an incremental feedforward collective pitch controller is proposed. The controller can be directly superimposed on the traditional collective pitch controller so that the incremental pitch angle can fully compensate wind influence. The effectiveness of the controller is verified by multi-software platform joint simulation and hardware-in-the-loop experiment. The results show that the controller can effectively reduce the wind turbine power and load fluctuation when the variation trend of wind speed in the rotor plane estimate by LiDAR data is the same as the actual wind speed.
Comparative study of thermally integrated pumped thermal energy storage based on the organic rankine cycle with different working fluid pairs
Authors: Jiang Xuhui , Zhang Xi , Wang Ruiqiong , Wang Xurong
Published: December 2023

Thermal integrated pumped thermal energy storage (TIPTES) systems with the features of high efficiency, flexibility, and reliability, have attracted increasing attention since they can integrate low-grade heat sources to further improve the utilization and economic viability of renewable energy. In this study, a typical TIPTES system driven by waste flue gas is established, and the heat pump and organic Rankine cycle (ORC) are chosen as the charging and discharging cycle, respectively. Four organic fluids, including R600, R245fa, R601a, and R1336mzz(Z), are selected to compose sixteen different working fluid pairs for thermodynamic analysis. The effects of key parameters, like heat pump system evaporation temperature and hot storage tank temperature, on system performance were analyzed, and the single-objective optimization was conducted. A comparative study was carried out to identify the best working fluid pair according to the optimization results. Results show that the system’s power-to-power efficiency goes up as the evaporation temperature increases while an increase in the heat storage temperature decreases the exergy efficiency of the TIPTES system. Optimization results show that the R245fa + R245fa is the best working fluid pair, and in this system, the ORC evaporator has the largest exergy destruction at about 260.84 kW, which is 20.2% of the total. On the other hand, the ORC pump has the smallest exergy destruction only about 0.5%. This study also finds that the system’s power-to-power efficiency of using different working fluids in either heat pump cycles or ORC cycles is lower than that of using the same working fluid throughout the entire system.
Reflections on Japan’s participation in negotiations of the global plastic pollution instrument under international environmental law
Authors: Xu Qi , Zhang Mengxue , Guo Peng
Published: December 2023

International negotiations towards a legally binding instrument on the global plastic pollution have obtained wide-ranging attention from international community. It is revealed that Japan has taken a conservative but proactive stance during negotiations. This study overviews Japan’s current legal framework on the management of plastic pollution including land and the sea. On this basis, the paper then analyzes Japan’s stance in the negotiations to examine the issues that are of most concern to Japan in international cooperation towards ending plastic pollution. It will further analyze Japan’s views on the legally binding instrument’s framework, operational mechanism and key components from the perspective of international environmental law. And it will also summarize Japan’s specific claims and objectives in the negotiations, and provide an evaluation of Japan’s stance.
Detecting ferroptosis and immune infiltration profiles in multiple system atrophy using postmortem brain tissue
Authors: Chen Linxi , Mao Lingqun , Lu Hongsheng , Liu Peng
Published: December 2023

Background

The importance of ferroptosis and the immune system has been mentioned in the pathogenesis of α-synucleinopathy. The α-synuclein-immunoreactive inclusions that primarily affect oligodendrocytes are the hallmark of multiple system atrophy (MSA). Limited evidence implicates that iron and immune responses are involved in the pathogenesis of MSA, which is associated with neurodegeneration and α-synuclein aggregation.

Methods

The RNA sequencing data were collected from the Gene Expression Omnibus database. MSA-C-related module genes were identified through weighted gene co-expression network analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to predict the potential molecular functions. The candidate ferroptosis-related genes associated with MSA-C were obtained using a machine-learning algorithm. CIBERSORT was used to estimate the compositional patterns of the 22 types of immune cells.

Results

The tissues for sequencing were extracted from postmortem cerebellar white matter tissues of 11 MSA-C patients and 47 healthy controls. The diagnostic ability of the six MSA-C-related ferroptosis-related genes in discriminating MSA-C from the healthy controls demonstrated a favorable diagnostic value, with the AUC ranging from 0.662 to 0.791. The proportion of CD8+ T cells in MSA-C was significantly higher than in the controls (P = 0.02). The proportion of NK cells resting in MSA-C was significantly higher than in the controls (P = 0.011).

Conclusion

Ferroptosis and T-cell infiltration may be important pathways of disease development in MSA-C, and targeting therapies for these pathways may be disease-modifying.
Telepresence robots as facilitators of physical exercise during COVID-19: a feasibility and acceptance study
Authors: Addas Abdullah
Published: December 2023

The COVID-19 pandemic and associated restrictions on mobility and access to green space have disrupted exercise habits worldwide. According to the World Health Organization (WHO), approximately 1.4 billion adults were insufficiently physically active in 2016, with detrimental impacts on health. The proposed study investigated the use of telepresence-robot-based personal trainers to facilitate remote exercise during the pandemic-related lockdowns. Several adults aged 18–65 were recruited for a four-week intervention and thorough research investigation. The intervention involved one-hour outdoor exercise sessions held three times per week in a local park with a human instructor connected via a telepresence robot. Surveys assessed perceptions of social presence, usability, the intention to use the robot and the psychological benefits of access to green space. System logs tracked participation and technical errors. At baseline, 30% of the participants met the WHO physical activity (PA) recommendations, compared to 80% after the intervention. The study shows significant increases in many parameters. These are perceived in social presence (p < 0.021), usability (p < 0.04), intentions for long-term use (p < 0.05), and the mental health benefits of accessing green spaces (p < 0.013). Attendance was found to be 90%, with a 7% technical failure rate. This investigation demonstrates the promise of telepresence robots for safely providing remote access to green spaces. They can be used to facilitate exercise during public health crises, overcoming the barriers to maintaining PA.
From Raw Data to Practical Application: EEG Parameters for Human Performance Studies in Air Traffic Control
Authors: Zamarreño Suárez María , Marín Martínez Juan , Pérez Moreno Francisco , Delgado-Aguilera Jurado Raquel , López de Frutos Patricia María , Arnaldo Valdés Rosa María
Published: December 2023

The use of electroencephalography (EEG) techniques has many advantages in the study of human performance in air traffic control (ATC). At present, these are non-intrusive techniques that allow large volumes of data to be recorded on a continuous basis using wireless equipment. To achieve the most with these techniques, it is essential to establish appropriate EEG parameters with a clear understanding of the process followed to obtain them and their practical application. This study explains, step by step, the approach adopted to obtain six EEG parameters: excitement, stress, boredom, relaxation, engagement, and attention. It then explains all the steps involved in analysing the relationship between these parameters and two other parameters that characterise the state of the air traffic control sector during the development of real-time simulations (RTS): taskload and number of simultaneous aircraft. For this case study, the results showed the highest relationships for the engagement and attention parameters. In general, the results confirmed the potential of using these EEG parameters.
Toward Effective Aircraft Call Sign Detection Using Fuzzy String-Matching between ASR and ADS-B Data
Authors: Kasttet Mohammed Saïd , Lyhyaoui Abdelouahid , Zbakh Douae , Aramja Adil , Kachkari Abderazzek
Published: December 2023

Recently, artificial intelligence and data science have witnessed dramatic progress and rapid growth, especially Automatic Speech Recognition (ASR) technology based on Hidden Markov Models (HMMs) and Deep Neural Networks (DNNs). Consequently, new end-to-end Recurrent Neural Network (RNN) toolkits were developed with higher speed and accuracy that can often achieve a Word Error Rate (WER) below 10%. These toolkits can nowadays be deployed, for instance, within aircraft cockpits and Air Traffic Control (ATC) systems in order to identify aircraft and display recognized voice messages related to flight data, especially for airports not equipped with radar. Hence, the performance of air traffic controllers and pilots can ultimately be improved by reducing workload and stress and enforcing safety standards. Our experiment conducted at Tangier’s International Airport ATC aimed to build an ASR model that is able to recognize aircraft call signs in a fast and accurate way. The acoustic and linguistic models were trained on the Ibn Battouta Speech Corpus (IBSC), resulting in an unprecedented speech dataset with approved transcription that includes real weather aerodrome observation data and flight information with a call sign captured by an ADS-B receiver. All of these data were synchronized with voice recordings in a structured format. We calculated the WER to evaluate the model’s accuracy and compared different methods of dataset training for model building and adaptation. Despite the high interference in the VHF radio communication channel and fast-speaking conditions that increased the WER level to 20%, our standalone and low-cost ASR system with a trained RNN model, supported by the Deep Speech toolkit, was able to achieve call sign detection rate scores up to 96% in air traffic controller messages and 90% in pilot messages while displaying related flight information from ADS-B data using the Fuzzy string-matching algorithm.
Mission Performance Assessment of the Recovery and Vertical Landing of a Reusable Launch Vehicle
Authors: Guadagnini Jacopo , De Zaiacomo Gabriele , Lavagna Michèle
Published: December 2023

This paper focuses on the mission analysis of the return trajectory of a Vertical Landing Reusable Launch Vehicle, both for Return-to-Launch-Site (RTLS) and DownRange Landing (DRL) recovery strategies. The main objective is to assess the mission performance of propellant-optimal re-entry and landing trajectories from the Main Engine Cut-Off (MECO) while considering propellant budget and peak entry conditions constraints. As a result, performance envelopes and feasibility regions are built to comprehensively assess the required propellant and compare recovery strategies across a broad spectrum of MECO conditions. The results show that the DRL strategy achieves higher efficiency concerning the propellant consumption and a larger robustness regarding the dispersed MECO conditions.
Comparison of Effectiveness and Selectiveness of Baited Traps for the Capture of the Invasive Hornet Vespa velutina
Authors: Rojas-Nossa Sandra V. , Mato Salustiano , Feijoo Pilar , Lagoa Aarón , Garrido Josefina
Published: December 2023

The invasive hornet Vespa velutina affects apiculture, biodiversity, and human health. The use of baited traps with the aim of reducing the population and mitigating its impacts is a common practice. However, the lack of impact on the number of colonies and the high capture rate of non-target insects make it controversial. Our objective was to compare the effectiveness and selectiveness of four trap models. We measured effectiveness as the capture rate of V. velutina per day per trap, and selectiveness as the capture rate of V. velutina/capture rate of non-target species. The E trap had better performance with a higher selectiveness and effectiveness. Traps V and X had a higher effectiveness but the lowest selectiveness, with high capture rates of native insects, including threatened species. The R trap had the lowest effectiveness and selectiveness. Results show that small changes in the design can contribute to achieving more sustainable tools. Otherwise, with the current tools, bait trapping continues to be non-sustainable from an environmental perspective due to the impacts on native biodiversity.
Kinematic and Morphometric Assessment of Fresh Semen, before, during and after Mating Period in Brahman Bulls
Authors: Araya-Zúñiga Ignacio , Sevilla Francisco , Molina-Montero Rafael , Roldan Eduardo R. S. , Barrientos-Morales Manuel , Silvestre Miguel A. , Valverde Anthony
Published: December 2023

The objective of the present study was to determine the effects that the reproductive season has on the motility, kinematics, morphology, and sperm morphometry of Brahman bulls evaluated with a commercial CASA system. The experiment was carried out at the Costa Rica Institute of Technology from March to August 2021. A total of eight Brahman bulls were used. A total of 28 ejaculates were collected in the pre-mating period (PMP), during it (DMP), and after it (AMP) using an electroejaculator. The sperm concentration was measured with the Accuread photometer. The motility was measured using a Spermtrack® counting chamber. The analyses were performed with the CASA-Mot ISAS®v1 system. The morphology was analyzed using a microscope with a negative phase contrast objective. Morphometry was evaluated with the CASA-Morph. The sperm concentration did not present differences between the PMP and AMP; however, it was significantly higher than DMP (p > 0.05). Regarding the progressiveness variables, linearity on forward progression (LIN), straightness (STR), and wobble (WOB) were higher (p < 0.05) DMP. A kinematic principal component analysis grouped all the variables into three factors and an effect on the reproductive period was found (p < 0.05) in the parameters of the head and middle part of the sperm, such as width and perimeter, which were greater in the PMP. The length of the sperm head in the PMP and DMP did not show differences; however, both were larger (p < 0.05) than AMP. The insertion distance of the middle piece of the sperm was significantly greater than DMP. Finally, the PMP contained cells with a larger insertion angle (p < 0.05) than AMP. These findings are important to understand the implications of reproductive status on sperm quality and to consider them in andrological evaluations.
Radar-SR3: A Weather Radar Image Super-Resolution Generation Model Based on SR3
Authors: Shi Zhanpeng , Geng Huantong , Wu Fangli , Geng Liangchao , Zhuang Xiaoran
Published: December 2023

To solve the problems of the current deep learning radar extrapolation model consuming many resources and the final prediction result lacking details, a weather radar image super-resolution weather model based on SR3 (super-resolution via image restoration and recognition) for radar images is proposed. This model uses a diffusion model to super-resolve weather radar images to generate high-definition images and optimizes the performance of the U-Net denoising network on the basis of SR3 to further improve image quality. The model receives high-resolution images with Gaussian noise added and performs channel splicing with low-resolution images for conditional generation. The experimental results showed that the introduction of the diffusion model significantly improved the spatial resolution of weather radar images, providing new technical means for applications in related fields; when the amplification factor was 8, Radar-SR3, compared with the image super-resolution model based on the generative adversarial network (SRGAN) and the bicubic interpolation algorithm, the peak signal-to-noise ratio (PSNR) increased by 146% and 52% on average. According to this model, it is possible to train radar extrapolation models with limited computing resources with high-resolution images.
Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review
Authors: Bhujel Basanta , Oh Se-Heon , Kim Chang-Min , Yoon Ye-Ji , Chung Ho-Seok , Ye Eun-Ah , Lee Hun , Kim Jae-Yong
Published: December 2023

Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered by various factors. This condition can lead to tear deficiencies, resulting in the desiccation of the ocular surface, corneal ulceration/perforation, increased susceptibility to infections, and a higher risk of severe visual impairment and blindness. Currently, the clinical management of DED primarily relies on supportive and palliative measures, including the frequent and lifelong use of different lubricating agents. While some advancements like punctal plugs, non-steroidal anti-inflammatory drugs, and salivary gland autografts have been attempted, they have shown limited effectiveness. Recently, there have been promising developments in the treatment of DED, including biomaterials such as nano-systems, hydrogels, and contact lenses for drug delivery, cell-based therapies, biological approaches, and tissue-based regenerative therapy. This article specifically explores the different strategies reported so far for treating DED. The aim is to discuss their potential as long-term cures for DED while also considering the factors that limit their feasibility and effectiveness. These advancements offer hope for more effective and sustainable treatment options in the future.
Association between Gray-Scale Ultrasound Imaging and Serological Creatine Kinase for Quantifying Exercise-Induced Muscle Damage: An Observational Study
Authors: Buffet-García Jorge , Vicente-Campos Davinia , López-Redondo Mónica , Sánchez-Jorge Sandra , Álvarez-González Javier , Plaza-Manzano Gustavo , Seijas-Fernández Tamara , Valera-Calero Juan Antonio
Published: December 2023

Limited evidence has verified if ultrasound imaging (US) can detect post-exercise muscle damage based on size, shape, and brightness metrics. This study aimed to analyze the correlation between creatine kinase (CK) concentration and (as a biomarker of muscle damage) changes in US gray-scale metrics after an exercise-induced muscle damage protocol. An observational study was conducted at a private university lab located in Madrid. Twenty-five untrained and asymptomatic volunteers were enrolled in this study. Baseline demographic data and body composition metrics were collected. In addition, the rectus femoris US data and CK concentration were assessed at baseline and after inducing muscle damage (24 and 48 h later). After calculating time differences for all the outcomes, the correlation between the changes observed with US and biomarkers was assessed. Significant CK concentration increases were found 24 h (p = 0.003) and 48 h (p < 0.001) after exercise. However, no significant changes in muscle size, shape, or brightness were found in any location (p > 0.05 for all). In addition, no significant associations were found between CK changes and US changes (p > 0.05 for all). Gray-scale US is not a sensitive tool for detecting muscle damage, as a protocol of exercise-induced muscle damage confirmed with CK produced no significant gray-scale US changes after 24 or 48 h. In addition, US and CK changes after 24 and 48 h were not associated with each other.
Annealing Effects of ZnO Thin Film on Photocatalytic Performances of Graphene Composites
Authors: Rafi Jobair Al , Kanda Yu , Honda Mitsuhiro , Ichikawa Yo
Published: December 2023

The hybrid structure of Graphene and ZnO (Graphene/ZnO) is emerging as a novel material used to achieve the high performance of photocatalysis. In this study, we examined the ZnO characteristics that affect the photocatalytic activity of graphene/ZnO using a lamellar structure of graphene and ZnO thin films. Graphene samples were synthesized via chemical vapor deposition, and a typical wet process was applied to transfer them on sputter-deposited ZnO thin films with and without annealing. We confirmed that graphene-deposited ZnO demonstrated more efficient photocatalytic behavior toward the decomposition of methylene blue (as a model organic compound) with ordinary sputtered ZnO thin films. Again, ZnO thin films annealed at 1000 °C in an N2 gas atmosphere with graphene performed better than unannealed films. XRD analysis confirmed that pre-thermal treatment of a ZnO thin film promoted re-crystallization, which had less impact on the photocatalytic improvement. The attachment of graphene to the film is considered to contribute to the enhancement. Raman analysis revealed that the graphene coverage areas on the post-annealed ZnO increased by two times compared to that of an unannealed film where the unannealed film had a higher graphene layer. The results presented in this study demonstrate that an annealed ZnO thin film forms a better attachment with graphene, resulting in a larger graphene coverage area with fewer multilayers, which effectively improves the photocatalytic activity in composite structures.
Concurrent Endometrial Cancer in Women with Atypical Endometrial Hyperplasia: What Is the Predictive Value of Patient Characteristics?
Authors: Giannella Luca , Piva Francesco , Delli Carpini Giovanni , Di Giuseppe Jacopo , Grelloni Camilla , Giulietti Matteo , Sopracordevole Francesco , Giorda Giorgio , Del Fabro Anna , Clemente Nicolò , Gardella Barbara , Bogani Giorgio , Brasile Orsola , Martinello Ruby , Caretto Marta , Ghelardi Alessandro , Albanesi Gianluca , Stevenazzi Guido , Venturini Paolo , Papiccio Maria , Cannì Marco , Barbero Maggiorino , Fambrini Massimiliano , Maggi Veronica , Uccella Stefano , Spinillo Arsenio , Raspagliesi Francesco , Greco Pantaleo , Simoncini Tommaso , Petraglia Felice , Ciavattini Andrea
Published: December 2023

Background: The rate of concurrent endometrial cancer (EC) in atypical endometrial hyperplasia (AEH) can be as high as 40%. Some patient characteristics showed associations with this occurrence. However, their real predictive power with related validation has yet to be discovered. The present study aimed to assess the performance of various models based on patient characteristics in predicting EC in women with AEH. Methods: This is a retrospective multi-institutional study including women with AEH undergoing definitive surgery. The women were divided according to the final histology (EC vs. no-EC). The available cases were divided into a training and validation set. Using k-fold cross-validation, we built many predictive models, including regressions and artificial neural networks (ANN). Results: A total of 193/629 women (30.7%) showed EC at hysterectomy. A total of 26/193 (13.4%) women showed high-risk EC. Regression and ANN models showed a prediction performance with a mean area under the curve of 0.65 and 0.75 on the validation set, respectively. Among the best prediction models, the most recurrent patient characteristics were age, body mass index, Lynch syndrome, diabetes, and previous breast cancer. None of these independent variables showed associations with high-risk diseases in women with EC. Conclusions: Patient characteristics did not show satisfactory performance in predicting EC in AEH. Risk stratification in AEH based mainly on patient characteristics may be clinically unsuitable.