bluuebunny/crossref_metadata_2025 huggingface dataset:
UJI EFEKTIVITAS DAN KEAMANAN KOMBINASI METFORMIN-VILDAGLIPTIN PADA DIABETES MELITUS TIPE 2 DI RSPAL Dr. RAMELAN SURABAYA
Authors:   RSPAL Dr Ramelan, Sari Dwi Octamy , Lorensia Amelia ,   Fakultas Farmasi, Universitas Surabaya, Rahem Abdul ,   Fakultas Farmasi, Universitas Airlangga, Lestiono Lestiono ,   RSPAL Dr Ramelan Surabaya
Published: January 2024

Metformin is the first-line therapy for Diabetes Mellitus (DM), which has not been able to control blood glucose in type 2 DM. One of the Dipeptidyl Peptidase IV Inhibitor (DPP4-I) groups, namely vildagliptin, has been included in the National Formulary which is used as a combination for the therapy of DM patients Type 2. Research objectives to know the effectiveness and safety of the combination of metformin-vildagliptin in type 2 DM at RSPAL Dr. Ramelan Surabaya. This research method uses a quantitative method with an observational study design, with retrospective data collection based on the Medical Records of Type 2 DM patients who first received metformin-vildagliptin combination therapy (n = 30) carried out observations, and recorded the results of Fasting Blood Glucose (GDP) examinations, Postprandial 2-hour blood glucose (GD2JPP), and HbA1C at baseline and after 3 months of therapy, and observed the safety of the combination. Results The metformin-vildagliptin combination reduced GDP 33.13 ± 40.73 mg/dL, GD2JPP 34.30 ± 48.81 mg/dL, and HbA1C 0.89 ± 0.86%. Did not show any side effects of hypoglycemia, but 3.33% experienced nausea/vomiting and dyspepsia. It was concluded that the combination of metformin-vildagliptin was able to reduce GDP, GD2JPP, and HbA1C.
KAJIAN DAMPAK EFEK SAMPING PENGGUNAAN OBAT OFF LABEL PADA PASIEN SISTEMIK LUPUS ERITEMATOSUS (SLE) TERHADAP BIAYA KESEHATAN
Authors:   Universitas Sari Mulia, Yuwindry Iwan , Yusri Yusri , Tangkas Hansel Hens
Published: January 2024

The main problem in conducting lupus treatment is that most drugs for the therapy provided have not been authorized so that they are still included in the class of off-label drugs for the treatment of lupus. The purpose of this study was only to see the impact of side effects of off-label drugs on health costs. This study was conducted using a cross-sectional method by means of a survey using the Naranjo Algorithm instrument (PESO Book) to determine the level of incidence of side effects that exist in LSE therapy using off-label drugs and calculate the health costs of lupus patients. The results showed that the most respondents were in adulthood (19 respondents 47.5%), then the most respondents were female (37 respondents or 92.5%). Data on the incidence of side effects obtained the most respondents in the Probable category (most likely to occur ROM) of 14 respondents or 35%. In addition, data on health costs incurred by more respondents experienced an increase, namely 23 respondents or 57.5%. The research data shows the calculated r value is 0.3044 and the Sig (2-tailed) value is 0.000 with a confidence level (CI) of 0.05. The results of the analysis clearly show that there is a significant relationship between the side effects of using off-label drugs on the health costs of lupus patients, where if the value of side effects experienced by respondents is high, the value of respondents' health costs is also high.
PERBANDINGAN KADAR BIOMARKER FUNGSI KUOGULASI TIKUS PUTIH (Rattus norvegicus) BERDASARKAN VARIASI DIET VEGETARIAN
Authors:   Fisiologi dan Fisika Medik, Fakultas Kedokteran Universitas Sriwijaya, Laeto Arwan Bin , Inggarsih Rara ,   Biologi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya, Purnamasari Septi , Diba Masayu Farah ,   Mikrobiologi Kedokteran, Fakultas Kedokteran Universitas Sriwijaya
Published: January 2024

Coagulation is an important physiological mechanism of the body to maintain optimal function of recovery. The success of this mechanism is determined by normal levels of biomarkers are involved, such as platelets. Deficiency of levels of these biomarkers can cause diseases, such as dengue fever, shock and hemophilia. Diet provides biochemical elements that the body can then use to synthesize platelets in the blood. The purpose of study was to compare the levels of biomarkers of coagulation function in white rats (Rattus norvegicus) with a variety of vegetarian diets. The method of study was using in vivo experimental research. The dependent variable is the level of platelets and the independent variable is a variety of vegetarian diets (quasi, lacto-ovo and vegan). The sampling technique used the Federer formula with are samples of 28 white rats. Statistical test using T test and Wilcoxon test. The research data showed that giving a vegetarian diet caused significant changes in platelet levels in the quasi, lacto-ovo and vegan vegetarian diet groups with a significant value for each group, namely p = 0.026, p = 0.042 and p = 0.001. While on the standard diet there was no significant change in platelet levels (p=0.291). On average, the highest platelet levels were found in the quasi-vegetarian diet group and the lowest in the standard diet group. In conclusion, the quasi-vegetarian, lacto-ovo and vegan diets affects the levels of blood coagulation biomarkers (platelets) in white rats.
FORMULASI DAN EVALUASI KESTABILAN FISIK SEDIAAN MASKER GEL PEEL-OFF DARI SARI BUAH LEMON CUI (Citrus microcarpa Bunge.)
Authors:   Universitas Islam Makassar, Arifin Arfiani , Suwitno Nurmadani ,   Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam Makassar, Sartini Sartini ,   Program Studi Farmasi, Universitas Hasanuddin
Published: January 2024

Lemon cui also known as fish lemon or kalamansi lemon is known to contain one of them vitamin C which has the potential as an antioxidant so that it can be applied as active ingredient in peel off mask preparations. The aims of this study weretoobtaining the best PVA concentration in the manufacture of peel-off gel masks from lemon cui juice that meet the stability test requirements. physique. The method of making a sample of lemon cui juice is obtained by grinding it using a blender, adding 100 mL of water and then separating the pulp to obtain the juice. The formulation of peel-off gel mask preparations uses variations in the concentration of PVA (Polyvinyl Alcohol), namely F1 (10%), F2 (13%) and F3 (16%). Physical stability tests included organoleptic tests, homogeneity tests, spreadability tests, pH tests, adhesion tests and drying time tests.The results showed that the preparations F1, F2 and F3 showed physical stability based on the results of organoleptic tests, homogeneity tests, spreadability tests, pH tests, adhesion tests and drying time tests before and after accelerated storage conditions. Based on the test results obtained, it can be concluded that the formulation of the Lemon Cui peel-off gel mask preparation from the three concentrations of PVA met the requirements for physical stability. The best PVA concentration is 10% because it has the best dry time.
HUBUNGAN DRUG RELATED PROBLEMS (DRPs) KATEGORI DOSIS OBAT AMLODIPIN DAN KAPTOPRIL TERHADAP KONDISI TEKANAN DARAH PADA PASIEN HIPERTENSI
Authors:   Jurusan Farmasi, Fakultas Kedokteran, Universitas Tanjungpura, Pontianak, Husnatika Husnatika , Nurmainah Nurmainah , Rizkifani Shoma
Published: January 2024

The incidence of drug-related problems (DRPs) in the dose category on the use of antihypertensive drugs has been associated with the failure of the patient's optimal blood pressure target. The study aims to analyze the relationship between drug-related problems (DRPs) on administering amlodipine and captopril drugs to the blood pressure conditions of elderly hypertensive patients in Puskesmas. This research is observational research with a cross-sectional design of analytical nature—purposive sampling techniques. The total number of samples meeting the inclusion and exclusion criteria was 435 patients. Analysis of DRPs dose category relationship data on administration of amlodipine and captopril against blood pressure conditions using a chi-square test. The results of the study showed that the characteristics of patients visited tended to be aged 65-69 years (53.33%), female (68,51%), stage II hypertensive (62.1%), amlodipine (80.92%). The incidence of the DRP dose category in stage II hypertensive (7.6%). Statistically known DRPs of amlodipine and captopril dosing categories showed different significance in each patient's condition of prehypertension (p=0.260), hypertension stage I (p = <0,001), hypertensive stage II (p<0,001). This study concludes, there is a relationship between the incidence of DRPs in the dose category in patients with stage I and stage II hypertension.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN JELANTIR (Conyza sumatrensis (Retz.) E. Walker) DALAM SEDIAAN DEODORAN SPRAY TERHADAP BAKTERI Staphylococcus epidermidis
Authors:   Program Studi Kimia, Fakultas Sains dan Teknologi Universitas Muhammadiyah Sukabumi, Destriawan Agis , Mulyani Reni , Muharam Salih
Published: January 2024

The bacteria Staphylococcus epidermidis is known to cause body odour in the human body. A common method to kill bacteria that cause body odour is deodorant. Commercial deodorants contain aluminium chlorohydrate and the compound is known to increase the risk of skin cancer and alzheimer's disease. A candidate for a safer deodorant is one made from natural ingredients. One of the natural ingredients that has potential as a deodorant is jelantir leaves. The purpose of this study was to extract and characterise phytochemical compounds and test their antibacterial activity in deodorant spray preparations on Staphylococcus epidermidis. The extraction method used was maceration using ethanol solvent, extract characterisation using UV-Vis spectrophotometry and antibacterial test of deodorant spray preparation of jelantir leaf extract using disc diffusion. The results showed that jelantir leaf extract contained flavonoids 5.5727 ±0.1336 (%w/w QE), saponins 8.6472 ±0.0353 (% w/w SE), tannins 2.1448 ±0.0506 (%w/w TAE), steroids 1.0231 ±0.0083 (%w/w BSE), triterpenoids 0.9090 ±0.0030 (%w/w UAE) and the antibacterial test results had the highest inhibition zone diameter of 13.50 ±0.50 (mm) in formula 30 (%w/v).
FORMULASI FILM FORMING SPRAY DARI KLORAMFENIKOL UNTUK LUKA
Authors:   Sekolah Tinggi Ilmu Kesehatan Samarinda, Helmidanora Rusdiati , Jubaidah Siti , Fauziah A. A. Isalukal
Published: January 2024

The wound healing process should be short so as not to interfere with productivity and reduce costs. SFFS (spray film forming system) is a combination of transdermal preparations in which a polymer solution is sprayed onto the skin and will form an almost transparent film by evaporation of the solvent. Film-forming solutions are particularly advantageous for transporting the active substance to the site of action by the shortest route in cases of dermal or lower tissue infections. Chloramphenicol is a lipophilic drug so it penetrates the skin well because the stratum corneum matrix is ​​also lipophilic. The purpose of this study was to make a formulation of a sprayed chloramphenicol film-forming solution in order to obtain the best formula and increase effectiveness. The research was carried out on an experimental basis and three formulas were prepared with different polymer concentrations. The results of the study obtained a film-forming spray for each formula with a film formed that was flexible and adhered well to the skin, with a pH of 6. The time needed to make the film layer in skin is 0.87-1.19 minutes with an average dose weight of spray is 61.33-85.33 mg.
Penggunaan Superdisintegrant Crospovidone Pada Sediaan Orally Disintegrating Tablet (ODT)
Authors: Fitriana Priyoni Nandhary , Prisiska Apt. Fahjar , Amalia Anisa
Published: January 2024

Orally Disintegrating Tablet (ODT) merupakan tablet yang bekerja cepat, mudah hancur dalam waktu kurang dari 60 detik, tidak meninggalkan rasa yang tidak enak di mulut ketika hancur dan praktis untuk dibawa berpergian. Komponen yang mempengaruhi waktu hancur tablet adalah superdisintegrant. Salah satu superdisintegrant yang banyak digunakan dalam pembuatan ODT adalah crospovidone. Tujuan dari studi literatur ini adalah untuk mengkaji pengaruh penggunaan crospovidone sebagai superdisintegrant terhadap sifat fisik ODT. Metode yang digunakan dalam tinjauan pustaka adalah narrative review yang mengelompokkan data – data sifat fisik ODT meliputi keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan dan waktu hancur tablet yang merupakan hasil kajian dari minimal 30 literature yang cocok dengan kriteria inklusi. Berdasarkan hasil kajian literatur diperoleh konsentrasi crospovidone yang dapat digunakan sebagai superdisintegrant pada sediaan ODT adalah 2 – 25%. Kesimpulan: Perbedaan konsentrasi crospovidone sebagai superdisintegrant pada formulasi ODT tidak mempengaruhi keseragaman bobot dan ukuran. Perbedaan konsentrasi crospovidone mempengaruhi hasil uji kekerasan, waktu hancur dan kerapuhan tablet. semakin tinggi jumlah konsentrasi crospovidone yang digunakan maka akan semakin cepat waktu hancur tablet.
Pembelajaran Budaya Banyumasan Berbasis Nilai Pancasila di Sekolah Dasar Negeri Karangdadap Kecamatan Kalibagor Kabupaten Banyumas
Authors: Ikhsan Bagus Nur , Wiyani Novan Ardiy , Rosita Tita
Published: January 2024

Peran penting pendidikan dalam memerangi kemiskinan pengetahuan, memecahkan masalah kebodohan, dan meningkatkan kondisi bangsa. Melalui pendekatan “merdeka belajar”, pemerintah berusaha memperbarui sistem pendidikan untuk beradaptasi dengan perubahan waktu dan teknologi. Salah satu contoh kebijaksanaan lokal yang dibahas adalah budaya banyumasan di Daerah Banyumas, Jawa Tengah, dengan aspek artistik, kuliner, dan ekonomi lokalnya. Tujuannya adalah untuk menggambarkan dan menganalisis perencanaan, implementasi dan evaluasi Pembelajaran Budaya Banyumasan berdasarkan nilai-nilai Pancasila di Desa Karangdadap Kecamatan Kalibagor. Guru secara hati-hati merencanakan pembelajaran, mengidentifikasi metode, model, media, dan langkah-langkah yang tepat melalui rencana modul ajar dan kurikulum sebagai panduan dalam pengajaran. implementasi pembelajaran. Budaya belajar yang didasarkan pada nilai-nilai Pancasila di SD Negeri Karangdadap dilakukan dengan menggunakan metode, model, dan media yang sesuai dengan materi yang diajarkan, terutama yang terkait dengan materi makanan khas daerah setempat yaitu gropak. Guru melatih siswa dengan pendekatan pembelajaran diluar kelas mengunjungi industri gropak setempat untuk memahami material lebih baik dan untuk membuat gropak menjadi lebih dikenal oleh lebih banyak orang. Evaluasi dan penilaian yang dilakukan guru secara berkala mengevaluasi perkembangan siswa melalui evaluasi diagnostik, formatif, dan sumatif. Guru mencatat kemajuan siswa dan memberi motivasi kepada siswa yang membutuhkan dukungan lebih lanjut dalam memahami materi. Sebagai kesimpulan, proses pembelajaran berjalan dengan baik dan menyeluruh, menggunakan metode yang tepat, serta evaluasi terstruktur untuk memastikan pemahaman siswa tentang materi pembelajaran.
Pengaruh CSR Score Terhadap Kredit Perdagangan pada Perusahaan Non-Jasa Keuangan di Negara Asean–5
Authors: Sukmawati Ika
Published: January 2024

Penelitian ini menginvestigasi pengaruh CSR (Corporate Social Responsibility) score dan kredit perdagangan pada Perusahaan non-jasa keuangan di negara-negara ASEAN-5. Dengan menggunakan analisis data panel non-linear, sampel yang digunakan sebanyak 643 perusahaan publik di Indonesia, Malaysia, Singapura, Thailand dan Filipina dari tahun 2013 sampai dengan tahun 2022. Hasil penelitian menunjukkan bahwa terdapat hubungan non-linear antara CSR score dan kredit perdagangan. Penelitian lebih lanjut diperoleh informasi bahwa ukuran Perusahaan memoderasi hubungan non-linear tersebut. Temuan ini menunjukkan bahwa pemasok akan lebih mudah memberikan kredit perdagangan pada Perusahaan yang memiliki CSR score yang terus membaik. Penelitian ini berkontribusi pada literatur yang ada dengan menunjukkan bahwa pengaruh CSR score terhadap kredit perdagangan tidak bersifat linier dan dapat dipengaruhi oleh ukuran perusahaan.
Pengaruh Literasi Digital, Literasi Informasi, dan Literasi Media Pada Guru Sekolah Dasar Terhadap Keberhasilan Penerapan Kurikulum Merdeka
Authors: Ngafifurrohman Ngafifurrohman , Sembiring Maximus Gorky , Alimuddin Johar
Published: January 2024

Penelitian ini menyelidiki pengaruh literasi digital, literasi media, dan literasi informasi terhadap keberhasilan penerapan Kurikulum Merdeka, khususnya pada penggunaan Platform Merdeka Mengajar di guru sekolah dasar di kecamatan Kroya. Penerapan Kurikulum Merdeka pada guru-guru tersebut secara umum mencapai skor rata-rata tinggi sebesar 60,12. Variabel literasi digital, literasi media, dan literasi informasi masing-masing memiliki pengaruh sebesar 74,5%, 67,4%, dan 86,2%. Ketiganya bersama-sama memberikan pengaruh sebesar 87,2%. Model regresi linear terbaik menghasilkan Adjusted R Square sebesar 87,6%, yang menunjukkan kombinasi literasi media dan literasi informasi memiliki pengaruh paling signifikan. Rekomendasi untuk guru adalah menguasai ketiga kemampuan literasi secara bersama-sama. Penelitian selanjutnya diharapkan melibatkan lebih banyak variabel bebas dan berlokasi di berbagai tempat untuk pemahaman yang lebih mendalam.
Development of the Tourism Industry Using Branding Strategies by Competitive Multimedia in the Digital Era Based on Community Empowerment
Authors: Kartinawati Erwin , Fitriyadi Farid , Indriastiningsih Erna
Published: January 2024

In a dynamic and ever-evolving digital era, the tourism industry faces the challenge of adapting and innovating to maintain its appeal. In this context, an effective branding strategy becomes crucial. Using or utilising competitive multimedia is one of the keys to achieving this goal. This research investigates the potential for integration between branding strategies through competitive multimedia and community empowerment in developing the tourism industry. Results show that when applied appropriately, competitive multimedia can strengthen identity, increase visibility, and deepen visitors' emotional engagement with tourism destinations. However, some technical challenges must be overcome, especially regarding the quality of promotional content. To overcome the problem, the proposed solution involves local communities deeply understanding the region's cultural richness and uniqueness in content production. With adequate training and access to the appropriate tools, communities can create content that is not only high quality but also authentic and rich in local narratives. Thus, this approach improves branding quality and promotes inclusive and sustainable tourism development. The main conclusion from this research is that the combination of multimedia technology and community empowerment can be a cutting-edge strategy for branding and promoting the tourism industry in the current digital era.
Strengthening Economic Literacy to Minimize Consumptive Online Shopping Behavior among Generation Z in West Lombok Regency
Authors: Fathurrahman  , Muhammad Habibullah Aminy  , Baiq Santi Rengganis  , Mardiyanto Rahayu Slamet
Published: January 2024

The growth and development of technology in everyday life has the potential to improve people's welfare. The level of public understanding of economic literacy is very important because it plays a role in economic management. The knowledge level of economic literacy in generation Z still needs strengthening. Therefore, community service activities were carried out in the form of strengthening economic literacy to minimize consumptive online shopping behavior among generation Z in Kekait Village, Gunungsari District, West Lombok Regency. Based on the community service activities that have been carried out, it can be seen that partners have given positive responses, including: acquiring new knowledge regarding economic literacy and digital financial platforms; the community wants to immediately implement good economic planning and management and intend to have digital savings. Sustainability of this activity is needed as a form of monitoring and evaluation of assistance in an effort to provide solutions to problems faced by partners.
УГОЛОВНАЯ ОТВЕТСТВЕННОСТЬ ЗА ГОСУДАРСТВЕННУЮ ИЗМЕНУ И ШПИОНАЖ В ЗАКОНОДАТЕЛЬСТВЕ НЕКОТОРЫХ ЗАРУБЕЖНЫХ СТРАН
Authors: Хаджиев У.К. , Ахъядов Э.С.-М.
Published: January 2024

Данная статья посвящена исследованию норм законодательств об уголовной ответственности за преступления государственной измены и шпионажа ряда зарубежных стран. Проводится детальный сравнительно-правовой анализ данного состава преступления.
ПРАВОВАЯ КУЛЬТУРА: ПОНЯТИЕ, СУЩНОСТЬ И СОВРЕМЕННЫЕ ТЕНДЕНЦИИ РАЗВИТИЯ
Authors: Оздамирова Л.М.
Published: January 2024

В статье исследуется сущность правовой культуры как понятие, приведены мнения ученых относительно его трактовки. Акцентируется внимание на особенностях категории «правовая культура». Правовая культура определена как совокупность достояний общества, его социальных групп и граждан в сфере регулирования общественных отношений, что способствует обеспечению верховенства права в общественной жизни, то есть господству основополагающих принципов справедливости и гуманизма, защите прав и свобод человека, его чести и достоинства, фактическому обеспечению места человека как высшей социальной ценности. Анализируется состояние правовой культуры в современной России, трудности формирования. Рассматривается проблема правового нигилизма в сознании граждан, восприятие ими права в контексте устоявшихся представлений о критическом положении правосознания молодого поколения. Обращается внимание на необходимость правового воспитания и образования российской молодежи. Определено, что высокий уровень развития правовой культуры – это сочетание соответствующих правовых знаний и персональной готовности человека применять их в регулировании собственного поведения.
РАЗМЕЩЕНИЕ ДЕПОРТИРОВАННЫХ НАРОДОВ В МЕСТАХ СПЕЦПОСЕЛЕНИЯ В ГОДЫ ВЕЛИКОЙ ОТЕЧЕСТВЕННОЙ ВОЙНЫ
Authors: Цуцулаева С.С. , Саидов И.Х.
Published: January 2024

В годы Великой Отечественной войны народы Северного Кавказа – карачаевцы, калмыки, чеченцы, ингуши и балкарцы были депортированы в восточные районы бывшего СССР. Республики Средней Азии и Казахстана были не готовы принять такое огромное количество спецпереселенцев. С первых же минут пребывания на спецпоселении чеченцы оказались в нечеловеческих условиях. Не было создано элементарных условий для жизни. Спепереселенцы выживали как могли. В итоге в первые годы на спецпоселении депортированные народы Северного Кавказа потеряли огромное количество людей – детей, стариков и женщин. Ведь они с первых дней войны, заменив мужчин, ушедших на фронт, ковали Победу в тылу, обеспечивая его всем необходимым.
ACCOUNTS OF PUBLIC ELEMENTARY SCHOOL TEACHERS ON INVOLUNTARY TRANSFER OF STATION: A PHENOMENOLOGY
Authors: Joash G. Gementiza  , Felvic B. Pernito
Published: January 2024

The purpose of this qualitative study, adopting the phenomenological approach, is to discover and understand the lived experiences of public elementary school teachers who were involuntarily transferred to a different station or school in the Division of Davao del Norte. In the data collection procedure, fourteen (14) teachers were selected through purposive sampling and they participated in the study. The participants were divided equally between in-depth interviews and focus group discussions to gather data from each of them. More importantly, trustworthiness and ethical considerations were applied in the data collection procedures, ensuring the total well-being of all participating teachers. From the participants, it was identified that they experienced struggling with financial strains, lack of school facilities and resources, challenges linked to long distance of school, predicaments relative to transitioning to multigrade classes, and electrical and internet connectivity challenges. They also revealed the different ways of coping that they had such as exhibiting positive traits and behaviors, fostering positive relationships and connections, highlighting support systems, and drawing inspiration from recognition and validation. They also realized the following insights which are namely fair and systematic approach in teacher transfers, see change as a constant thing that must be accepted, pursue personal and professional goals, and emphasize positive relationships. While most of the participants were able to adapt to the situation, the Department of Education may also reflect upon the findings of this study and may always seek to prioritize the well-being of all public-school teachers who breathe life into the basic education system that we are having today.
KEYWORDS: involuntary transfer, public schools, elementary teachers, phenomenological research, Davao del Norte
STOCK MARKET SENSITIVITY TO CRUDE OIL AND FOREX PRICE MOVEMENTS-A STUDY ON NIFTY 50 INDEX
Authors: Sandeep Kumar Patra  , Prof. Prabodha Kumar Hota
Published: January 2024

This study examines the impact of the USD/INR Exchange rate, and the per-barrel prices of WTI Crude oil in rupees on the Nifty 50 index, utilizing monthly data spanning from January 1, 2010, to September 30, 2023. The analysis primarily involves the utilization of the closing returns of the nifty index, the West Texas Intermediate (WTI) oil price per barrel in dollars, and exchange rates. The classical OLS method is sued to analyse the relationship between Nifty, crude oil, and crude oil prices over 166 months. The results reveal that exchange rates have a negative coefficient, suggesting that an increase in exchange rates is associated with a decrease in Nifty50 returns. In addition, the CUSUM test confirms the stability and consistency of our model over time, supporting the absence of structural breaks. This study underscores the dynamic nature of financial markets and highlights the importance of continuous monitoring and risk management strategies.
KEY WORDS: Nifty 50, Crude Oil, Exchange Rate
Design and optimization of 3D-bioprinted cell-laden scaffolds in dynamic culture
Authors: Li Jing , Chen Feng , Wang Meixia , Zhu Xiaolong , He Ning , Li Na , Zhu Haotian , Han Xiaoxiao
Published: January 2024

Light-based 3D printing enables the fabrication of biological scaffolds with high precision, versatility and biocompatibility, particularly the cell-laden scaffolds with architecturally complex geometric features. However, many bioprinted tissue scaffolds suffer from low cell viability due to insufficient oxygen and nutrient supply, which is heavily influenced by scaffold structure and cultivation conditions. Current practice relies mainly on resource-intensive trial-and-error methods to optimize scaffolds’ structures and cultivation parameters. In this study, we developed a comprehensive multi-physics model integrating fluid dynamics, oxygen mass transfer, cell oxygen consumption, and cell growth processes to capture cell growth behaviors in scaffolds, establishing a robust theoretical foundation for scaffold structure optimization. The modeling results showed that a large number of parameters, such as system inlet flow rate, geometric feature size, cell parameters, and material properties, significantly impact oxygen concentration and cell growth within the scaffold. A two-step optimization strategy is proposed in this paper and was applied to obtain optimal geometric parameters of channeled scaffolds to demonstrate the model’s effectiveness for scaffold optimization. The model can be employed for scaffolds with arbitrary shapes and various materials, facilitating the optimal design of sophisticated scaffolds for more advanced tissue engineering.
Transgenic sugarcane for the sustainable management of the sugarcane borer Diatraea saccharalis
Authors: Budeguer F. , Racedo J. , Enrique R. , Perera M.F. , Ostengo S. , Noguera A.S.
Published: January 2024

The sugarcane borer Diatraea saccharalis is a major pest of sugarcane (Saccharum spp. hybrids) in the Americas. The insect is partially controlled by cultural, biological, and chemical methods but still causes significant economic losses to sugarcane growers and processors. Currently, one of the most efficient strategies for pest control in other crops is the use of transgenic plants harbouring genes from Bacillus thuringiensis (Bt), which encode crystalline proteins (Cry and/or Vip) with insecticidal activity, known as Bt genes/proteins. In sugarcane, the expression of individual Bt proteins has been previously reported, but not the stacking of two or more Bt proteins. In this study, Bt genes were incorporated by microprojectile bombardment into embryogenic sugarcane calli of the clones TUC 95-10 and TUC 03-12. The presence of the transgenes in 33 transgenic lines was verified by using PCR assays. Subsequently, transgenic lines were acclimated and multiplied in the greenhouse to generate vegetative material for their phenotypic and molecular assessments. The expression levels of transcripts in candidate lines were quantified by real time quantitative PCR (qRT-PCR) assays. In conclusion, transgenic sugarcane lines with a higher level of expression of Bt transcripts compared with the control were developed. These promising lines will be used for future phenotypic tests to determine their resistance against D. saccharalis.
Using spectral sensing in plant science
Authors: Paulus Stefan , Pichler Lea , Barreto Abel
Published: January 2024

Digital cameras are widely used tools for plant monitoring in plant science today. Used to track plant growth or even visible symptoms, they are important tools for breeding and plant protection field trials. Nevertheless, its extension to measure the near infrared (NIR) region (700–1000 nm) includes great potential as plants show a higher light reflectance within this spectrum. Various applications have shown its use for disease detection, quantification, virus content estimation, and stress monitoring. As the next step is a comprehensive integration into agricultural routines, this study will show two use-cases with a high technological readiness level. One use-case shows a handheld multispectral sensor, which is used for manual measurements to detect and discriminate different virus types in sugar beet. In contrast, the second use-case shows a transfer to an UAV based disease quantification routine based on spectral imaging for Cercospora leaf spot. In addition, two prototypical workflows are shown for processing non-imaging and imaging spectral data in an agricultural setting. This study shows the state of the art in spectral sensing in the field for the two major sugar beet diseases – virus yellows and Cercospora leaf spot. Furthermore a future perspective for coming technological challenges regarding the integration of AI in sensors or robotic workflows is provided.
Pengaruh Budaya Lokal terhadap Pelaksanaan Hukum Pidana di Indonesia
Authors: Pratama Anggerdi Adji , Robekha Jamiatur , Mulya Musa Alam
Published: January 2024

Dalam konteks hukum pidana, meskipun ada regulasi formal yang berlaku di seluruh negeri, budaya lokal seringkali berperan penting dalam pelaksanaannya. Oleh karena itu, memahami interaksi antara budaya lokal dan pelaksanaan hukum pidana di Indonesia menjadi esensial untuk menjamin efektivitas dan keadilan dalam sistem hukum. Studi ini menerapkan pendekatan kualitatif, menggabungkan metode analisis literatur. Informasi yang dikumpulkan bersifat deskriptif, baik dalam bentuk tertulis maupun lisan. Pendekatan berbasis peraturan perundang-undangan diadopsi untuk mengumpulkan berbagai undang-undang dan regulasi yang relevan, sementara analisis literatur membantu dalam memahami konteks isu hukum yang dibahas. Hasil menunjukan walaupun otoritas resmi seperti kepolisian dan pengadilan tetap berperan, lembaga adat seringkali menjadi tempat pertama untuk mediasi dalam menyelesaikan konflik, khususnya yang berakar pada isu lokal. Hal ini mengindikasikan bahwa nilai-nilai tradisional dan budaya menduduki tempat penting dalam masyarakat dan mempengaruhi bagaimana masyarakat berhubungan dengan sistem hukum yang formal.
Different Techniques to Obtain Demucilated Flour from Taro Rhizome, Yield, Qualitative and Instrumental Analyzes
Authors: Andrade Luan Alberto , Nunes Cleiton Antonio , Pereira Joelma
Published: January 2024

The mucilage extracted from the taro rhizome has interesting characteristics that allow it to be used in the food industry as a thickener, stabilizer, emulsifier, and substitute for lipids in bakery products. During the extraction of this mucilage, there was the formation of a subproduct still unknown to science in every technique used. The study of this residue is interesting even though, at first, there is no application for it. However, it can be produced in high quantity if the taro mucilage is extracted at a high scale, adding to the value of the culture of taro rhizomes. The objective of this work is to characterize, in a preliminary way, the demucilated taro flour obtained through two different mucilage extraction techniques at two different temperatures: room temperature and 80 ℃. The extraction at room temperature and high temperature (80 ℃) was followed by filtration in polyester fabric and drying. The yield of each flour was calculated, and then, the Biuret and Iodine tests were performed for protein and starch detection, respectively, as well as the obtaining of the infrared spectrum. The presence of starch was detected in all the flours studied. Meanwhile, the protein was only present in the demucilated flour obtained through the extraction process at high temperatures. The infrared spectra indicated the presence of carbohydrates in both flours. The flours have differences in yield and chemical composition due to the obtaining techniques. Other analyses of chemical, physical, and technological properties are a point of interest for future works.
The Role of Tourism in Sustainable Development Within Local-Global Dynamics
Authors: Nyaupane Gyan P.
Published: January 2024

Divergent priorities, interests, and agendas among local and global communities form the core of the conservation versus development debate. The intricate challenges facing humanity in the 21st century demand a more comprehensive approach to analyzing issues and exploring alternative
solutions. This article aims to integrate tourism, a burgeoning service industry, into the local-global and conservation-development nexus. It posits tourism as a mutually acceptable common ground for both local and global communities in the conservation and development agenda. Furthermore,
this article presents a model illustrating how tourism can serve as a tool for sustainable development.
The Effect of Spiritual Emotional Freedom Technique (SEFT) Therapy on Reducing Labor Anxiety in Primigravida
Authors: Emilia Emilia
Published: January 2024

Labor anxiety is a psychological condition experienced by most maternity mothers. Childbirth anxiety can cause various negative impacts, such as prolonged labor, surgical delivery, and even maternal death. Spiritual emotional freedom technique (SEFT) therapy is a non-pharmacological therapy that can be used to reduce labor anxiety. This study aims to analyze the effect of SEFT therapy on reducing childbirth anxiety in primigravida. This research uses a quasi-experimental method with a pretest-posttest control group design. The research sample consisted of 26 primigravidas who were divided into two groups, namely the treatment group (13 people) and the control group (13 people). SEFT therapy was given to the treatment group for 3 sessions. The results of the study showed that there was a decrease in birth anxiety in the treatment group after being given SEFT therapy. This is indicated by the average value of labor anxiety in the treatment group, which decreased from 29.83 in the pretest to 21.77 in the posttest. Meanwhile, in the control group, the average value of labor anxiety did not change, namely 28.08 in the pretest and 28.08 in the posttest. Based on the results of this study, it can be concluded that SEFT therapy can reduce labor anxiety in primigravida.
Depressive Symptoms in Heart Failure: Pathophysiology and Diagnosis
Authors: Taskura Risfandi Ahmad , Murti Putri Utami
Published: January 2024

Depression commonly affects individuals with heart failure and is associated with higher mortality rates, increased disability, healthcare costs, and reduced quality of life. Heart failure patients are more likely to experience depression. This study was aimed to describe pathophysiology and treatment of depression in heart failure patients. Both physiological and behavioral variables may influence the relationship between depression and the development and progression of heart failure, as well as increased rates of mortality. Because of the similarities between the symptoms of cardiac and mental illnesses, it may be difficult to make an appropriate diagnosis of depressive disorders in individuals who are suffering from heart failure. Further research is urgently needed to improve the diagnosis of these disorders and develop therapies that benefit patients with heart failure.
An Overview of Aggressive Behaviors in Children with Autism Spectrum Disorder
Authors: Satopoh Flavia Angelina
Published: January 2024

Children and adolescents with autism spectrum disorder (ASD) frequently exhibit symptoms of irritability and aggression, which may appear as tantrums, self-injury, and violent behaviors. As a result, parents often bring their children to the emergency room or seek psychiatric treatment. Aggression refers to conduct that poses a threat or inflicts injury by bodily or verbal actions, such as striking, biting, hurling things, or using offensive language against another individual. Aggressive behaviors can detrimentally impact the patient's quality of life, increase their stress levels, and hinder their ability to get educational and social assistance. A multidisciplinary approach is crucial for assessing patients and selecting the most effective treatment. Both non-pharmacologic and pharmacologic treatments are available to address violent behavior in children with ASD. As a health practitioner, it is crucial to understand the circumstances that might trigger aggressiveness in children with ASD and possess the knowledge and skills to effectively manage and treat these patients. By doing so, we can optimize their outcomes and enhance their overall quality of life.
Implementasi Dan Pemanfaatan Blended Learning Bagi Mahasiswa STMIK Pranata Indonesia
Authors: Farizy Salman , Andrianto G.
Published: January 2024

Abstract

Entering the beginning of 2020 the world community was shocked by the corona virus outbreak (Covid19), the rapid spread and infected patients who were suspected of being able to spread through physical contact also through the air and could cause death caused the World Health Organization (WHO) to declare the world into a global emergency related this virus corona virus outbreak has had an impact on the education sector. Almost all students or students around the world are disrupted in their school activities or lectures and result in the threat of their educational rights in the future. By utilizing online technology it is hoped that all work can continue to be carried out to support work or the learning and teaching process. Implementation and Utilization of E-Learning where students and lecturers can communicate or interact easily from long distances and different places Moodle is one of the applications of the concepts and mechanisms of teaching and learning that utilize information technology, known as electronic learning concepts or e- learning.

Kata Kunci : E-Learning, Covid19, Moodle, LMS, Implementasi, Pasca Covid.
The Effect of Therapeutic Communication on the Anxiety Level of Children Undergoing the COVID-19 Vaccination
Authors: Naufal Irfan Hanif , Harnanto Addi Mardi , Sunarto Sunarto , Widodo Widodo , Sudiro Sudiro
Published: January 2024

Background: Anxiety is often encountered in society, especially in children, when undergoing the COVID-19 vaccination. Anxiety is a factor influencing children to refuse vaccination. Therefore, nurses need to reduce this level of anxiety through the application of therapeutic communication. This research was carried out to determine the effect of therapeutic communication on children's anxiety levels during the implementation of the COVID-19 vaccination.
Methods: A pre-experiment design with a one-group pretest-posttest design was used on 58 respondents who were selected using a simple random sampling technique. The research instrument used was the Zung Self-Rating Anxiety Scale (SAS/SRAS) questionnaire with a Likert scale model, and the results were analyzed using the Wilcoxon Signed Ranks Test statistical test.
Results: The results of the Wilcoxon Signed Ranks Test analysis on respondents' anxiety levels showed that there was a decrease in anxiety after therapeutic communication was carried out with a p-value of 0.00 (p < 0.05), which means that therapeutic communication had a significant influence on the anxiety level of children undergoing the COVID-19 vaccination.
Conclusion: Therapeutic communication can effectively reduce the anxiety level of children undergoing COVID-19 vaccination.
Economic Consequences of Artificial Intelligence and Labor Automation: Employment Recovery, Transformation of Labor Markets, and Dynamics of Social Structure in the Context of Digital Transformation
Authors: Tokunova Anastasiia , Zvonar Viktor , Polozhentsev Dmytro , Pavlova Valentyna , Fedoruk Olesia
Published: January 2024

Globalization, industrialization, and digitalization have led to structural changes in the economy and labor markets, affecting their internationalization, flexibility, labor mobility, and the emergence of new forms of employment. The purpose of the academic paper is to identify the economic consequences of digital transformation and automation of labor markets in the example of the EU-27 countries for the period 2013-2022. The structural-functional analysis was used in the academic paper to characterize and systematically study the economic consequences of digitalization and automation in the labor markets of the EU-27 countries. The functioning of the labor market in various EU-27 countries in the context of digital transformation is characterized by several features. The EU-27 labor markets are characterized by rapid employment recovery, especially during the pandemic and economic downturn in 2020, and employment revival in 2021-2022. In the Member States, a stable level of employment is generally observed; there is a decrease in the share of people with 0-2, and 3-4 educational attainment levels, while the share of people with 5-8 educational attainment levels is growing, and there is a stable growth in wages and incomes. Changes in the social structure of the employed by vocational and educational levels and qualifications in favor of increasing the importance and role of higher education have been revealed. Changes in forms of employment and the emergence of new forms of employment (sharing of workers and workplaces, temporary management, casual labor, ICT-based mobile work, voucher work, portfolio work, crowd employment, and collaborative work) have been identified.
International Remittances, Human Resources Outflow & Economic Growth: Dynamic Regression Models
Authors: Mulska Olha , Vasyltsiv Taras , Voznyak Halyna , Mitsenko Nataliia , Kaplenko Halyna , Ivaniuk Uliana
Published: January 2024

The article presents an econometric analysis of the impact and elasticity of human resources outflow and remittance with economic growth in Ukraine. It is proved that remittance (1) has a direct relationship with economic activity rate, (2) a cyclical and multiplicative relationship with the inflationary process, and (3) an indirect effect on capital investment. It has been established that migration favorably affects the financial well-being of households and is an effective measure for accumulating investment capital and savings. The trigger for economic growth in the vector of ‘migration – remittance’ is the development of the migration capital market by increasing the investment capacity of remittance’, ensuring the target remittance orientation to the small and medium-sized business sector, guaranteeing market stability (security of remittance) and developing financial inclusion.
PENGAMALAN BUDAYA SIPAMANDAQ DI PERUSDA ANEKA USAHA MAJENE DALAM REALISASI PERTANGGUNGJAWABAN SOSIAL DAN LINGKUNGAN
Authors: Rahim Nur hidayah , Ilyas Herlina
Published: January 2024

Aspek budaya dalam akuntansi dapat menentukan perilaku akuntan, proses akuntansi, hingga laporan akuntansi yang dibuat oleh perusahaan. Bagi perusahaan daerah, kearifan lokal sejatinya merupakan core value yang dapat dijadikan referensi dalam pengelolaan usaha termasuk proses akuntansi. Sipamandaq merupakan budaya suku Mandar yang masih jarang diteliti utamanya kaitannya dengan pertanggungjawaban sosial dan lingkungan bagi perusahaan yang beraktivitas di sekitar wilayah suku Mandar termasuk Perusda Aneka Usaha Majene. Penelitian ini bertujuan untuk mengetahui aktualisasi budaya Sipamandaq dalam upaya Perusda Aneka Usaha Majene merealisasikan pertanggungjawaban sosial dan lingkungan. Metode penelitian menggunakan metode kualitatif dengan pendekatan etnografi dimana data diperoleh melalui wawancara mendalam dan studi dokumen utamanya laporan keuangan.  Kesimpulan penelitian yaitu Perusda Aneka Usaha Majene belum merealisasikan pertanggungjawaban sosial dan lingkungan secara optimal dimana kontribusinya tidak memenuhi perwujudan nilai utama sipamandaq yaitu saling melindungi namun telah mengupayakan perwujudan nilai lainnya yaitu sirondo-rondoi (kerja sama), siamasei (saling menyayangi), dan sianuang pa’mai (susah sama susah-senang sama senang) dengan mendukung operasional pemerintah daerah Kabupaten Majene.
PENGARUH KOMPETENSI DAN SARANA PRASARANA TERHADAP KINERJA DOSEN MELALUI PROSES PEMBELAJARAN DI POLITEKNIK ILMU PELAYARAN (PIP) MAKASSAR
Authors: Musriady Musriady , Echdar Saban , Rahman Nawir
Published: January 2024

Penelitian ini bertujuan untuk untuk mengetahui dan menganalisis pengaruh kompetensi dan sarana prasarana terhadap kinerja dosen melalui mediasi proses pembelajaran di Politeknik Ilmu Pelayaran (PIP) Makassar.
Penelitian menggunakan metode deskriptif dan verifikatif dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh dosen di Politeknik Ilmu Pelayaran (PIP) Makassar, sebanyak 100 orang. Menggunakan teknik sampel Jenuh, yaitu teknik penentuan sampel apabila semua anggota populasi digunakan sebagai sampel.
Hasil penelitian ini menunjukkan bahwa : Kompetensi dan sarana prasarana berpengaruh positif dan signifikan terhadap proses pembelajaran di Politeknik Ilmu Pelayaran (PIP) Makassar, Kompetensi, sarana prasarana dan proses belajar berpengaruh positif dan signifikan terhadap kinerja dosen di Politeknik Ilmu Pelayaran (PIP) Makassar, Kompetensi berpengaruh signifikan terhadap kinerja dosen melalui proses belajar di Politeknik Ilmu Pelayaran (PIP) Makassar, Sarana prasarana berpengaruh signifikan terhadap kinerja dosen melalui proses belajar di Politeknik Ilmu Pelayaran (PIP) Makassar.