bluuebunny/crossref_metadata_2025 huggingface dataset:
A bivalent CMV vaccine formulated with human compatible TLR9 agonist CpG1018 elicits potent cellular and humoral immunity in HLA expressing mice
Authors: Dasari Vijayendra , Beckett Kirrilee , Horsefield Shane , Ambalathingal George , Khanna Rajiv
Published: June 2022

There is now convincing evidence that the successful development of an effective CMV vaccine will require improved formulation and adjuvant selection that is capable of inducing both humoral and cellular immune responses. Here, we have designed a novel bivalent subunit vaccine formulation based on CMV-encoded oligomeric glycoprotein B (gB) and polyepitope protein in combination with human compatible TLR9 agonist CpG1018. The polyepitope protein includes multiple minimal HLA class I-restricted CD8+T cell epitopes from different antigens of CMV. This subunit vaccine generated durable anti-viral antibodies, CMV-specific CD4+and CD8+T cell responses in multiple HLA expressing mice. Antibody responses included broad TH1 isotypes (IgG2a, IgG2b and IgG3) and potently neutralized CMV infection in fibroblasts and epithelial cells. Furthermore, polyfunctional antigen-specific T cell immunity and antiviral antibody responses showed long-term memory maintenance. These observations argue that this novel vaccine strategy, if applied to humans, could facilitate the generation of robust humoral and cellular immune responses which may be more effective in preventing CMV-associated complications in various clinical settings.
Protecting our future: What contribution can I make?
Authors: Gesang Bernward
Published: June 2022

(A) The crises related to climate and the economy endanger future and current generations but altering the small impact or minimal emissions of an individual person is—because of the failure of political coordination—not the best way to overcome these crises. (B) When we act as individuals to act as stopgaps for policy to minimise the mountain of problems, the following applies: We should not waste our energies on limited involvements in small, primarily symbolic collaborations but should instead endeavour to make the biggest difference of which we are capable with regard to improving the world. (C) We make the biggest difference when our limited budget for improving the world is used against poverty, for example, and combatting poverty is precisely what brings positive side effects with regard to human rights and the protection of the climate, animals, and species. For example, support for poor farmers in rain forests can save those rain forests. Every CO2 calculator demonstrates that commitment to the Third World is up to 50 times more efficient than reduction of personal emissions.
Liber Amicorum: Homenaje al Profesor José María Hernández Díaz
Authors: García Redondo Eva , Vega Gil Leoncio
Published: June 2022

El libro que hemos tenido a bien coordinar está dedicado a la figura y la obra de un «universitario ejemplar», como lo es, y siempre lo será, el profesor José María Hernández Díaz, Catedrático de Historia de la Educación de la USAL y docente de la misma durante 45 años. Ha sido posible gracias a la aportación generosa de amigos y compañeros de España, Portugal, Colombia, Italia, Gabón, Francia, México, Brasil, Bélgica, Países Bajos, Chile y Uruguay. Este es un documento que combina la cultura material y la inmaterial, el afecto y la consideración, lo social y lo académico, lo intelectual y lo universitario, la historia y el futuro, el saber y el saber hacer, el pensamiento y la acción, la entrega y el reconocimiento, las cosas y las no cosas. En relación con su estructura organizativa, ésta se inicia con las presentaciones, lúcidas y con cierta carga espiritual, de las autoridades académicas (Rector y Director del Departamento) y de los coordinadores. Continúa con la magistral Última Lectio del profesor Hernández Díaz sobre el oficio de historiador de la educación en la universidad postmoderna. A continuación, hemos incluido el apartado dedicado a las semblanzas y la academia; este apartado está lleno de recuerdos, anécdotas, reflexiones, vivencias, experiencias, miradas, etc., con o a causa del homenajeado. También un bloque dedicado a la investigación que hemos denominado aportaciones científicas que recoge textos de investigación histórico educativa de distintos compañeros y universitarios, conectados con las temáticas objeto de atención del profesor Hernández Díaz. La estructura se cierra con una recopilación sintética de la voluminosa producción intelectual del compañero y amigo objeto del homenaje. Este también es un libro social, académico y universitario que pretende mapear la trayectoria intelectual, social y pedagógica de un maestro universitario que transita por la universidad deseada, tanto en términos de memoria como de proyecto.
Evaluation of the customer requirements for last mile delivery in Brazil
Authors: Souza Nicollas Luiz Schweitzer de , Stradioto Neto Luciana Amaral , Fettermann Diego de Castro , Frazzon Enzo Morosini
Published: June 2022

Goal: This paper aims to understand the value of possibility of scheduling, cost of scheduling, app technology and reschedules features that embody the last mile logistics system.Methodology: The method utilized a stated preference technique in a sample of 83 potential consumers in Florianopolis/Brazil.Results: The results show that consumers are interested and willing to pay for services and amenities such as scheduling at the time of purchase and associated technology. This finding corroborates the pricing process for online product delivery and confirms the trend toward customer-customized systems.Limitations of the investigation: This research is limited in the scope of methodology. Practical implications: The presented result can be used by companies to be able to use the right attributes in the last mile process.Originality: The Last Mile is the logistics stage that delivers most value to the end customer. Therefore, there is present in the literature the difficulty of interpreting what the customer most expects in terms of service at this logistical stage. Then, understanding which features are important to the customer is a good way to implement improvements in the last mile logistics.
THE ASSOCIATION BETWEEN KNOWLEDGE AND THE READINESS OF HEALTH WORKERS IN IMPLEMENTING WIFI TB PROGRAM
Authors: Rizfi Kumala Aulia , Kholis Fathur Nur , Julianti Hari Peni , Adespin Dea Amarilisa
Published: June 2022

Background: Semarang city contributes to reducing the number of missing TB cases by using Wajib Notifikasi TB (WiFi TB) application program, which began to be used simultaneously in 2018. WiFi TB application is an application to record and report every TB case found by health facilities, and it is part of Directly Observed Treatment Short-course (DOTS) strategy in monitoring, recording, and reporting component. Aim: Knowing the association between knowledge and the readiness of health workers in implementing WiFi TB program. Methods: The research design used in this study was analytic observational with a cross sectional approach. The qualitative method was also used in this study to know the evaluation about the implementation of WiFi TB program from the subjects. The sample size of this study were 27 subjects using purposive sampling method from each of the 10 Primary Clinics in Semarang city that included inclusion criteria. Data were collected by recording the results of answers to questionnaires and interviews. Fisher exact was used to test the hypothesis. Results: Most of the health workers from each of the 10 Primary Clinics in Semarang city had good readiness in implementing WiFi TB program. The results of this study showed a significant association between knowledge (p = 0,030) and the readiness of health workers in implementing WiFi TB program. Conclusion: There was an association between knowledge and the readiness of health workers in implementing WiFi TB program.Key Words: Tuberculosis, WiFi TB, readiness, knowledge
Comparison of Intraocular Pressure (IOP) Value Before and After Vitrectomy in Diabetic Retinopatic Patients
Authors: Saubig Arnila Novitasari , Rahmi Fifin Luthfia , Hutami Hesti Triwahyu
Published: June 2022

Background: Diabetic retinopathy is one of the second highest complications of microangiopathy in Indonesia due to diabetes mellitus in the form of damage to retina of the eye and can cause blindness in adults. The management of diabetic retinopathy is done by operative measure, one of which vitrectomy. However, this procedure can lead to an increase in the value of intraocular pressure after surgery. In this study, analysis of differences in intraocular pressure values before and after vitrectomy was carried out in patients with diabetic retinopathy.Research Purpose: To know, compare, and analyze the intraocular pressure values before and after vitrectomy in patients with diabetic retinopathy.Method: The study design was an analytic observation with a study design cross-sectional. Sampling using method consecutive sampling obtained from medical record of 45 diabetic retinopathy patients who underwent vitrectomy at the RSND for the period July-December 2019. After the data was collected, the data were analyzed using the difference Wilcoxon rank test.Result: A total of 45 diabetic retinopathy patients underwent vitrectomy from medical records were dominated by 24 people aged >69 years and 26 female patients. The mean values of intraocular pressure before and one week after vitrectomy were 20.32 + 2.57 mmHg and 23.89 + 9.24 mmHg. The results showed that there was a higher intraocular pressure value after vitrectomy than before vitrectomy in diabetic retinopathy patients (p=0.021) or p,0.05
THE EFFECT OF COFFEE ON THE SPERMATOZOA MOTILITY OF MALE WISTAR RATS (Rattus norvegicus) EXPOSED TO ELECTRIC CIGARETTE SMOKE
Authors: Avianty Erika Shinta , Dewi Puspita Kusuma , Setyawati Amallia Nuggetsiana , Mochtar Arufiadi Anityo
Published: June 2022

Background: Man infertility was caused by decrease of spermatozoa quality. E-cigarette smoke which contained chemicals as nicotine could produce free radicals which decreased spermatozoa motility. Coffee was contained of caffeine and chlorogenic acid functioned as antioxidant and increase spermatozoa motility. Aim: To prove the coffee giving effect to spermatozoa motility of male wistar rats that have been exposed to e-cigarette smoke. Methods: The sample were 28 male wistar rats (Rattus norvegicus), no anatomical abnormalities, 200-300 grams, and 8-9 weeks. The sample was randomly divided into 4 groups: no treatment, the rats which were exposed to e-cigarette smoke, the rats which were given 3ml robusta coffee solution contained of 180mg coffee powder and exposed to e-cigarette smoke, the rats which were given 3ml robusta coffee solution contained of 360mg coffee powder and exposed to e-cigarette smoke. The coffees solution was given through a gastric swab. The e-cigarette liquid doze was 3,5ml with 18mg/ml nicotine for each group. After four weeks, the rat’s sperm sample was taken, preparation was made, and spermatozoa motility was examined through microscope. The statistical test exerted Saphiro-Wilks test and non-parametrical test from Kruskal-Wallis. Results: The mean of spermatozoa motility percentage in progressive, non-progressive, and negative control group immotility = (53,81±6,507), (30,00±5,444), (16,66±3,333); positive control = (0,48±1,259), (17,14±18,604), (82,38±19,787); first treatment = (10,00±4,304), (32,85±14,065), (57,14±17,259); second treatment = (11,42±1,779), (26,19±8,033), (62,38±8,760). Kruskal-Wallis test showed a significant difference in progressive motility and immotility (p=0,000). Conclusion: The coffee solution could give an effect on the spermatozoa motility of male wistar rats exposed to electric cigarette smoke.                                Keywords: Infertility, e-cigarette, nicotine, coffee, motility
The Association between Face Mask Use and Headache: A Challenge in the New Normal Era
Authors: Utama Wira Dharma , Purnamayani Erlina
Published: June 2022

Abstract Background: Indonesia has entered a new normal in the Covid-19 era and implemented strict health protocols in day-to-day activities. Transportation sectors, including air transportation, have been allowed to continue their services as long as they follow the health protocols, such as the mandatory use of face masks. Unfortunately, face masks now deal with several negative health issues, e.g., headache.Objective: To observe the association between face mask use and headache among airport officers and the average degree of the headache experience.Methods: The study was conducted at the Sultan Mahmud Badaruddin II (SMB II) International Airport in Palembang. The data were collected by a questionnaire gathered from December 2020 to January 2021. The data were processed using a quantitative approach with analytical methods.Results: From 207 airport officers, the major characteristics were female (57.9%), indoor workplaces (78.3%), face masks use ≤ 4 (four) hours per day (58.9%), and no headaches while using face masks (70.1%). There was a significant relationship between headache and face masks used > 4 hours per day (p < 0.001; 95% CI = 6.201 {3.215-11.958}). The mean of headaches degree using the VAS score was 2.3 (scale 0 - 10).Conclusion: Headaches could result from wearing facemasks for more than 4 hours per day. The mean degree of headaches due to facemasks used was relatively mild. The present research suggests that face masks must not cause other health problems. Improvement in face masks is the key to facing the Covid-19 pandemic and as important as washing hands and physical distancing.Keywords: Face mask; Headache; VAS Score
Characteristics of Endometriosis Patients in RSUP Dr. Kariadi Semarang in 2018
Authors: Mansur Syarifah A , Trisetiyono Yuli , Muniroh Muflihatul , Setiyorini Nurul
Published: June 2022

Background : Endometriosis is one of the gynecological disorders that affects women at reproductive age between 20-35 years. Based on the above, endometriosis can cause pain that can interfere daily activity and infertility.Aim : To found the incidence and characteristics of patients with endometriosis who undergoing treatment and surgery in RSUP Dr. Kariadi Semarang Method: This study was a descriptive study. Data retrieved from medical records of endometriosis’s patients who undergoing treatment and surgery at RSUP Dr. Kariadi Semarang 2018. The result presented in distribution and frequency characteristics tables.Result : The incidence of endometriosis in RSUP Dr. Kariadi Semarang in 2018 were 176 cases of 8690 inpatients in the obstetric and gynecology wards. Characteristics of endometriosis patients are most at the age of 20 - 35 years, nullipara, with complaints of menstrual pain / dysmenorrhoea, location in the ovary, by managing the surgery and using GnRH agonists, and not a recurrent endometriosis patient.Conclusion : The incidence of endometriosis in RSUP Dr. Kariadi Semarang 2018 was 176 cases of 8690 patients at the Obstetrics and Gynecology (2 %). Endometrosis highest incidence was in the reproductive age (20-35 years).
Air Pollution Exposure Duration and Its Correlation with Triglyceride, HDL, and Atherogenic Index in Online Motorcycle Drivers
Authors: Herawan Adrian Stefanus , Limijadi Edward Kurnia Setiawan , Hermawati Donna , Batubara Lusiana
Published: June 2022

Background: The most restoration material used currently in dentistry was composite resin. The newest generation of composite resin was bulk-fill composite resin. The bulk-fill composite resin had advantages of lower polymerization contraction and a more straightforward and faster restoration technique. One of the factors which could affect the hardness of composite resin was the consumption of acidic drinks. The acidic beverage that people often consumed is coffee. A few coffee brewing methods were espresso and drip brewing.Objective: This research aimed to identify the effects of coffee soaking through espresso and drip brewing methods on bulk-fill composite resin's hardness.Methods: his research was experimental research, with a post-test control group design and a total sample of 27 samples. The soaking process was taken for seven days at a temperature of 37˚C on artificial saliva, espresso, and drip brewing coffee methods. The hardness of bulk-fill composite resin was measured after seven days by using Vickers hardness. The statistic test exerted One-Way ANOVA.Results: This research found a significant difference in bulk-fill composite resin's hardness among all groups, p-value = 0.00 (p<0.05). The result of the post-hoc LSD test showed a significant difference in the change of bulk-fill composite resin hardness between the artificial saliva group and espresso group (p=0,00) and no significant difference found between the artificial saliva group and drip brewing group (p=0.85).Conclusion: Soaking with espresso coffee has the smallest hardness value compared to soaking with drip brewing coffee and artificial saliva, so soaking with espresso coffee is the most influential on the hardness of the bulk fill composite resin.
Factors Affecting Patient Adherence to Pharmacological Therapy in Gout Arthritis and Hyperuricemia
Authors: Setyawan Dzaki Edmonda , Mahati Endang , Maharani Nani
Published: June 2022

Abstract Background: Pharmacological therapy to reduce serum uric acid levels in gouty arthritis and hyperuricemia patients is essential to prevent gout flare and other hyperuricemia-related morbidities. However, only about 50% of gout arthritis patients adhered to their treatment. Knowing the factors influencing adherence to therapy can be used as a reference for health services to improve adherence.Objective: This study aimed to analyze the factors that influenced the patient's adherence to gouty arthritis and hyperuricemia pharmacological therapy.Methods: This was an observational study with a cross-sectional approach. Subjects were the patients in Wuryantoro Community Health Center, Wonogiri Regency, diagnosed with gouty arthritis or hyperuricemia due to a disorder in purine metabolism. Sampling was done by a consecutive sampling method. Questionnaires with the related medical record were used to collect the necessary data. Research variables were knowledge, attitudes and behavior, gender, age, occupation, insurance, distance from residence to health care facilities, and adherence to therapy which was in binary.Results: Sixty-one percent from a total of 41 respondents were found to be non-adherence to pharmacological therapy. Knowledge, attitudes, and behavior towards therapy, educational level, availability of health insurance, and distance to health facilities were significantly correlated to treatment adherence (p < 0.05). Sex, age, and occupation were not correlated to adherence.Conclusion: Factors influencing adherence were knowledge, attitudes and behavior, academic background, insurance, and the distance from residence to health care facilities.
The Relationship Between Academic Procrastination and Sleep Quality of Students of Medical Study Program, Faculty of Medicine, Diponegoro University During the COVID-19 Pandemic
Authors: Pusparini Athaya Zayyan , Saktini Fanti , Asikin Hang Gunawan , Sumekar Tanjung Ayu
Published: June 2022

Background: The COVID-19 pandemic requires the government to take policies by establishing online learning. Online learning has significantly provided changes to students' daily activities, thus resulting in academic procrastination. Academic procrastination is defined as an act of postponing academic activities that may lead to decreased academic performance, increased physical, emotional, mental problems, and unhealthy sleep patterns. Sleep is referred to as a crucial activity of daily routines, and poor sleep quality may contribute to negative impacts on academic success. Aim: To evaluate the relationship between procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic. Method: This research used a cross-sectional design. Subsequently, 84 active students of the Faculty of Medicine, Diponegoro University, Class of 2020, were found to meet the research criteria, agreed to the informed consent, and filled out the complete questionnaire. The statistical test used was Spearman's test analysis. Results: Referring to the results obtained, there was no significant relationship between academic procrastination and sleep quality for students during the COVID-19 pandemic. Moreover, 39 (46.4%) students were identified as having a high level of academic procrastination. Meanwhile, the majority of students with poor sleep quality during the COVID-19 pandemic was amounted to 52 (61.9%). Conclusion: There was no significant relationship between academic procrastination and sleep quality for students of the Medical Study Program, Faculty of Medicine, Diponegoro University, during the COVID-19 pandemic.
CASE PRESENTATION OF 55-YEAR-OLD MAN WITH ACUTE MYELOID LEUKEMIA AND COVID 19
Authors: Sari Novita Fajar , Wulanjani Herniah Asti , Jaludamascena Ardhea , Retnoningrum Dwi
Published: June 2022

Background: Acute myeloid leukemia (AML) is a malignancy originating from multipotential hematopoietic cells, which is characterized by clonal proliferation of abnormal blast cells in the bone marrow and failure of normal cell production. Coronavirus disease-19 (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. COVID-19 infection in AML patients will affect laboratory examinations to support the diagnosis of COVID-19 and the patient's prognosis. Case presentation: A 55-year- old man went to the hospital for chemotherapy and diagnosed of acute myelomonocytic leukemia. Patient complains of his gingival bleeding. The results of the routine haematological examination showed pancytopenia and the patient requires blood transfusion before chemotherapy. On the third day of treatment, the patient complained of fever, after several day patient complained cough, and shortness of breath. Physical examination showed pulse 100x/minutes, respiratory rate 26x/minutes, temperature 39.8˚C, crackles of the lungs. RT-PCR examination from nasopharyngeal swab showed a positive SARS-CoV-2. During treatment, the laboratory tests showed pancytopenia, increased D-Dimer, C-reactive protein, ferritin and procalcitonin. After the 42th day of treatment, the patient had clinical improvement, the fifth evaluation swab showed a negative RT-PCR result. Conclusion: AML patients have a higher risk of infection, especially COVID-19 infection. Correct laboratory examinations and treatment will promote a better prognosis. It is necessary to educate leukemic patients so that they always take precautions against infection, especially the prevention of COVID-19.
THE EFFECT OF CORIANDER LEAVES EXTRACT ON THE DEGREE OF WISTAR RATS LIVER MICROSCOPIC DAMAGE WAS GIVEN MERCURIC CHLORIDE ORALLY
Authors: Ardiani Zefania Regina , Sudaryanto Sudaryanto , Istiadi Hermawan , Hadi Hadi
Published: June 2022

Background Mercury is a heavy metal that is widely used in various aspects of human life. However, mercury exposure can damage the liver. The high antioxidant found in coriander leaves is expected to be a solution to the problem in preventing liver damage due to mercury exposure. Aim Proving that administration of coriander leaf extract can reduce the degree of wistar rats liver microscopic damage due to mercury exposure. Methods Experimental study with post test only control group design for 14 days, used 24 male Wistar rats, divided randomly into 4 groups : C (-), C (+) (given mercury orally 10 mg / kgBW), X1 ( given mercury orally 10 mg / kgBW and coriander leaf extract 100 mg / kgBW) and X2 (given mercury orally 10 mg / kgBW and coriander leaf extract 200 mg / kgBW). On the 15th day, rats were terminated, the livers were harvested, microscopic preparations were made and stained with Hematoxylin-Eosin. Observed with a magnification of 400x in 5 different fields of view of each sample and were assessed using Manja Roenigk's score. Results Were obtained normal, mild damage, moderate damage, and severe damage respectively in the group: C (-): 80%, 20%, 0%, 0%; C (+): 0%, 3%, 67%, 30%; X1: 47%, 33%, 17%, 3%; X2: 77%, 23%, 0%, 0%. Spearman test found significant correlation (p = 0,000) with storng correlation ( r = 0.781) and the direction between the two variables is negative (-) . Kruskal Wallis test found significant differences (p = 0,000). Continued Mann Whitney test found significant differences between groups C (-) with C (+) (0,000), C (-) with X1 (0.004), C (+) with X1 (0,000), C (+) with X2 (0,000) ), and X1 with X2 (0.007) and the difference is not significant between C (-) and X2 (0.756). Conclusion Giving coriander leaves extract can reduce the degree of microscopic damage of Wistar rat liver due to mercury exposure.
THE EFFECT OF VCO TO THE GROWTH OF CANDIDA ALBICANS ON DENTURE BASIS OF ACRYLIC RESIN
Authors: Fatmasari Vivi Indah , Hapsari Rebriarina , Hardini Nadia , Lestari Endang Sri
Published: June 2022

Background: Acrylic resin was a material of denture base which frequently used, but it still had a weakness that it was porous, then, it was often the breeding ground of Candida albicans. Virgin coconut oil (VCO) contained fatty acid which was effective to hamper the growth of C.albicans. Objective: This research was to identify the effect of VCO on the growth of C.albicans on acrylic resin denture. Methods: This research was an experimental laboratory research which exerted post-test control group design. The total sample 24 which were divided into 3 groups of treatment and 1 group of control. The treatment covered acrylic plates soaking which have been contaminated with C.albicans suspension into VCO in concentration level 25%, 50%, 75%, and sterile aquades for 8 hours. The acrylic plate was vibrated to knock out C.albicans and was then continued by colony counting on the media of Sabouraud Dextrose Agar (SDA). The statistic test employed Kruskal-Wallis and continued to the Post-Hoc test which employed Mann-Whitney. Findings: The VCO in concentration level 25%, 50%, and 75% affected to inhibit the growth of C.albicans. In the Kruskal-Wallis test, it was found a significant difference between the number of C.albicans on the control group and the VCO in concentration level 25%, 50%, and 75% (p<0,05). The Post-Hoc Mann-Whitney test indicated no significant difference between VCO in concentration level 25% and 50%, 25% and 75%, also 50% and 75% (p>0,05). Conclusion: The VCO in concentration level 25%, 50%, and 75% affected was able to hamper the growth of C.albicans. Further, there was no significant difference in each VCO concentration.
THE EFFECT OF THE ACIDITY OF FERMENTED MILK AGAINST THE HARDNESS OF NANOHYBRID COMPOSITE RESIN
Authors: Sinaga Hanny Tiara A , Purbaningrum Diah Ajeng , Ariosta Ariosta , Retnoningrum Dwi
Published: June 2022

Background : The hardness of nanohybrid composite resin can decrease due to the acidic condition of the oral cavity. The acidic condition of the oral cavity can cause continuous degradation in composite resin. Fermented milk is a beverage that is widely sold in the market and is good for consumption however this beverage has the acid potential of hydrogen (pH) which can reduce the composite resin toughness. Aim : To determine the acidity effect of fermented milk on the hardness of nanohybrid composite resin. Method: Experimental study with a post test control group design. There were 27 samples of nanohybrid composite resin. One time immersion for three seconds in each group of beverages namely Milk, Cimory, and Yakult. After 15 days, a composite resin hardness test was performed using a Micro Vickers Hardness Tester with a load of 100 grams for 10 seconds. Statistical tests using One Way ANOVA. Results: The nanohybrid composite resin exhibited significant reduction in hardness between three beverage groups. Post hoc LSD test showed that there were significant differences between Milk with Yakult (p = 0.006) and Cimory with Yakult (p = 0.008) while Milk with Cimory (p = 0.907) did not have significant. Conclusions : There is a effect of fermented milk influences the hardness. There is a significant difference between Milk and Yakult and between Cimory and Yakult and there is no significant difference between Milk and Cimory.
Kajian Literatur: Massage untuk Peningkatan Kualitas Tidur pada Pasien Kritis
Authors: Sari Nindya Rachma Gardhika , Utami Reni Sulung
Published: June 2022

Introduction: Sleep disturbance is one of the complaints in criticaly illl patients and have an impact on the patient's physical and psychological condition. Research on the effect of massage therapy on sleep quality has been widely studied with various techniques and outcomes. This study aims to review the evidence regarding the location, equipment, dose and timing of massage that can improve sleep quality in critically ill patients.Methods: This research method is a literature review. Literature is searched through electronic database such as EBSCOhost, Scopus, Science Direct, ProQuest, Clinical Key, SpringerLink and Portal Garuda. The keywords used are massage, massages, reflexology,”pemijatan”, “pijat”, sleep, sleep disturbance, sleep deprivation, sleep apnea, sleep quality, quality of sleep, critical area, critical patients, intensive care unit, and ICU. The inclusion criteria of article was  an experimental research design that tested the effect of massage on improving sleep quality, full text articles and published from January 2011 to May 2021. Data were analyzed in a narrative manner and grouped according to the searched theme, namely location/area, equipment, dose and timing of massage.Results: Search results found 107 articles, but only 9 articles were eligible to be reviewed. The review indicate that massage has a significant effect on improving sleep quality. The combination of hand and valerian or lavender essential oil is the most appropriate way. Feet are the most numerous and effective area. Massage dose is once a day with repetitions for two consecutive days with a duration of 10-20 minutes and it carried out before bedtime.Suggestion: This result recommend the application of massage to improve the sleep quality of critically ill patients. However, massages which given to critically ill patients must be carried out by certified nurses or expert in massage.
Keterikatan Anak Sekolah Dasar di Desa Pagar Dalam, Provinsi Lampung terhadap Ruang Bermain
Authors: Adhanto Diko Hary , Sumadio Widyawati
Published: June 2022

Sense of place adalah upaya sesorang untuk memahami ‘status’ mereka dalam dunia dan membentuk rasa identitas diri. Dari sense of place ini seseorang memiliki identitas tempat. Identitas tempat sendiri berkembang karena penjelajahan seseorang di lingkungan terdekatnya. Penjelajahan lingkungan di awali sejak usia dini dengan berbagai cara. Salah satu cara menjelajahi lingkungan adalah dengan bermain. Tujuan penelitian ini adalah untuk mengetahui pola ruang bermain anak berdasarkan karakteristik tempat, dan karakteristik demografi anak. Metode pengumpulan data dilakukan melalui pemetaan mental kepada 80 anak kelas 1 hingga 5 dan pengukuran indeks keterikatan tempat kepada 44 anak yang duduk di kelas 4 dan 5 Sekolah Dasar, di Desa Pagar Dalam, Provinsi Lampung. Hasil dari penelitian ini adalah 75% anak-anak pedesaan memilih bermain di lingkungan dekat rumahnya. Tingkat identitas dan ketergantungan tempat pada semua ruang bermain bernilai baik. Sedangkan interpretasi peta mental, elemen alam pada kategori penilaian memiliki skor yang hampir dominan pada beberapa ruang bermain. Kesimpulan dalam penelitian ini adalah anak pedesaan cenderung memilih ruang bermain yang dekat dengan lokasi tempat tinggal mereka dan adanya perluasan jangkauan dalam mengeksplorasi ruang bermain yang lebih jauh berdasarkan umur dan gender. Keterikatan fungsional dan keterikatan emosional anak terhadap ruang bermain berbeda-beda dengan elemen alam yang sangat dominan.
Nowy, wspaniały i dostępny świat
Authors: Ostrowska Barbara E. , Chrzanowski Marcin M.
Published: June 2022

Nauczanie przedmiotów przyrodniczych najczęściej kojarzy się z przekazywaniem informacji, faktów i opisów zjawisk – czyli ugruntowanej wiedzy do przyswojenia przez uczniów. Na zajęciach zwykle brakuje czasu na refleksje związane z naturą tych przedmiotów, a co za tym idzie z ich wykorzystaniem do przygotowania ucznia do trochę innego świata. Świata, w którym większość informacji znajdziemy w sieci. Dostęp do nich jest natychmiastowy, ale jakość bardzo różna. Należy więc wyposażyć młodego człowieka w umiejętności niezbędne do świadomego funkcjonowania. Skupienie uwagi na krytycznym myśleniu, stosowaniu metody naukowej, a właściwie próby ukształtowania „nawykowego” myślenia według reguł tej metody, dyskusji o fake newsach, pseudonauce czy niepewności naukowej wydaje się być niezwykle ważne. W publikacji podjęto próbę zasygnalizowania, które umiejętności można rozwijać na zajęciach z przedmiotów przyrodniczych przy weryfikacji i ograniczeniu przekazywanych treści.
TESTING FOR HERD BEHAVIOR IN BORSA ISTANBUL DURING THE COVID-19 PANDEMIC
Authors: YALÇIN Devrim , AYBARS Aslı
Published: June 2022

The concept of herd behavior is based on the nature of decentralized acting investors’ pseudo-collaborative behaviors in the market. This study investigates the herd behavior phenomenon for Borsa Istanbul (BIST) amidst the new coronavirus outbreak. The whole period is split into symmetrical two discrete one-year sub-periods considering the median date of March 11th, 2020, the official announcement date of the first domestic COVID-19 case. The paper proceeds with the models based on the Cross-sectional mean absolute deviation (CSAD) and the Cross-sectional standard deviation (CSSD) test methodology to test for probable herd behavior, using daily stock closing prices of the BIST 100 index shares during the period from March 11th, 2019 to March 9th, 2021.
TÜRK ANA METAL SANAYİ ŞİRKETLERİNİN COVID-19 PANDEMİSİ DÖNEMİNDEKİ FİNANSAL PERFORMANSLARININ ENTROPİ – MARCOS BÜTÜNLEŞİK YAKLAŞIMI İLE DEĞERLENDİRİLMESİ
Authors: GÖNÜLLÜ Ozan
Published: June 2022

Dünya Sağlık Örgütü’nün (WHO) Mart 2020’de pandemi olarak ilan ettiği COVID-19 salgınının yol
açtığı küresel üretim daralması, birçok ülkenin ekonomisini durma noktasına getirmiştir. Türk imalat
sektörünün lokomotifi konumunda olan ana metal sanayisi de pandemiden en çok etkilenen sektörlerin
başında gelmektedir. Sektördeki şirketlerin finansal performansları, yöneticilerin ve sermaye piyasası
yatırımcılarının karar verme süreçlerini ciddi bir şekilde etkilemektedir. Bu çalışmada Borsa İstanbul Metal
Ana Endeksinde (XMANA) yer alan 20 şirketin pandemi dönemi finansal performansı analiz edilmiştir.
Pandemi dönemi (2020/06 – 2021/06) analiz sonuçları bir önceki bir yıllık dönem ile karşılaştırılmış ve
önemli değişimlere rastlanmıştır. Performans ölçümü amacı ile bilanço ve gelir tablolarından derlenmiş;
likidite, kârlılık, maliyet, değer, büyüme, sermaye yapısı ve faaliyet oranlarından oluşan 15 farklı kriter
belirlenmiştir. Çalışmada çok kriterli karar verme tekniklerinden Entropi Yöntemi kriterlerin önem
ağırlıklarının hesaplanmasında; 2020 yılında geliştirilmiş yeni bir yöntem olan MARCOS Yöntemi ise
şirketlerin belirlenen kriterlere göre sıralanmasında kullanılmıştır. Çalışma sonuçlarına göre, pandemi
dönemi finansal performansı en yüksek firma olan ÇEMTAŞ Çelik Makina Sanayi ve Ticaret A.Ş.
(CEMTS)’yi; sırasıyla Kardemir Karabük Demir Çelik Sanayi ve Ticaret A.Ş. (KRDMD) ve AYES Çelik
Hasır ve Çit Sanayi A.Ş. (AYES) takip etmiştir.
A comprehensive review on electric vehicles: charging and control techniques, electric vehicle-grid integration
Authors: Femy P. H. , Jayakumar J.
Published: June 2022

Energy consumption in the field of transportation comes next to industrial consumption worldwide. If transportation is completely powered by renewable energy, the utilization of fossil fuels can be drastically reduced, which will result in a lesser amount of greenhouse gas emissions. Electric vehicles (EVs) can act as an alternative to make transportation pollution-free. Large-scale usage of EVs causes high electricity demand on the supply system. This problem can be overcome by utilizing renewable energy sources (RESs) for Electric Vehicle charging. Due to the unpredictability of RESs, coordinating EV charging with other loads and renewable generation is problematic. By using EVs as energy units, power fluctuations in the electric grid can be compensated. This paper presents a summary of recent research in the domain of integration of electric vehicles (EVs) to the smart grid. Electric vehicles-smart grid integrated systems face several issues related to communication, grid infrastructure and control in the future power system. Smart grid technologies are summarized in Section 2. The existing research articles in this area are classified into two based on the purpose: EVs integration into the electric grid and Vehicle to grid services. Finally, the research gaps and future scope of incorporating electric vehicles with renewable energy sources and the Smart grid are highlighted.
Formal verification of multiplier circuits using computer algebra
Authors: Kaufmann Daniela
Published: June 2022

Digital circuits are widely utilized in computers, because they provide models for various digital components and arithmetic operations. Arithmetic circuits are a subclass of digital circuits that are used to execute Boolean algebra. To avoid problems like the infamous Pentium FDIV bug, it is critical to ensure that arithmetic circuits are correct. Formal verification can be used to determine the correctness of a circuit with respect to a certain specification. However, arithmetic circuits, particularly integer multipliers, represent a challenge to current verification methodologies and, in reality, still necessitate a significant amount of manual labor. In my dissertation we examine and develop automated reasoning approaches based on computer algebra, where the word-level specification, modeled as a polynomial, is reduced by a Gröbner basis inferred by the gate-level representation of the circuit. We provide a precise formalization of this reasoning process, which includes soundness and completeness arguments and adds to the mathematical background in this field. On the practical side we present an unique incremental column-wise verification algorithm and preprocessing approaches based on variable elimination that simplify the inferred Gröbner basis. Furthermore, we provide an algebraic proof calculus in this thesis that allows obtaining certificates as a by-product of circuit verification in order to boost confidence in the outcomes of automated reasoning tools. These certificates can be efficiently verified with independent proof checking tools.
Research biography of a distinguished expert in the field of inverse problems: Professor Eric Todd Quinto
Authors: Agranovsky Mark , Boman Jan , Hasanov Alemdar , Felea Raluca , Frikel Jürgen , Krishnan Venky , Novikov Roman , Ramlau Ronny , Sebu Cristiana
Published: June 2022

This article gives a brief overview of the research in microlocal analysis, tomography, and integral geometry of Professor Eric Todd Quinto, Robinson Professor of Mathematics at Tufts University, along with the collaborators and colleagues who influenced his work.
“It’s like the root of a tree that I grew up from….”: parents’ linguistic identity shaping family language policy in isolated circumstances
Authors: Ellis Elizabeth Margaret , Sims Margaret
Published: June 2022

A key factor that has been found to be critical in shaping family language policy is parents’ linguistic identities, or “parents’ personal experiences with bilingualism, biculturalism or second language learning” (King, Kendall A. & Lyn Fogle. 2006. Bilingual parenting as good parenting: Parents’ perspectives on family language policy for additive bilingualism. International Journal of Applied Linguistics 9(6). 695–712, p. 703). In other words, parents’ experiences of languages will colour and influence both their aims for their children’s plurilingualism, and the practices that they bring to bear to that end. This proposition was explored in a paper by Sims, Margaret, Elizabeth M. Ellis & Vicki Knox. 2017. Parental plurilingual capital in a monolingual context: Investigating strengths to support young children in early childhood settings. Early Childhood Education Journal 45. 777–787 (p. 779), that “parents construct their own understandings of plurilingualism based on their own experiences with languages” meaning that the parents’ linguistic identity indeed provides the potential and the basis for bringing up their children as plurilinguals. This paper, based on an Australian ARC-funded study, reports on the link between parents’ linguistic identity and their family language policy, on their impact beliefs (De Houwer, Annick. 1999. Environmental factors in early bilingual development: The role of parental beliefs and attitudes. In G. Extra & L. Verhoeven (eds.), Bilingualism and migration, 75–95. Berlin, Germany: Mouton de Gruyter, p. 83), on the ways in which their aims for their children’s language development are articulated and put into practice, and on how they deal with their children’s emerging linguistic identity as plurilinguals, in a linguistically isolated context in regional New South Wales.
Zur affektiven Dynamik in Interviews mit Sexarbeitenden
Authors: Beyer Manuela , Küster Anna-Sophia
Published: June 2022

Anhand der Analyse von Interviews mit Sexarbeitenden zeigt dieser Beitrag auf, wie affektiv-emotionale Prozesse in der Interviewsituation mit den Spezifika des Forschungsfeldes, vor allem der Marginalisierung und Stigmatisierung der Sexarbeitenden, zusammenhängen. Im Zentrum der Analyse steht die Rekonstruktion von Ressentiments und anderen Gefühlen sozialer Auf- und Abwertung, die einen elementaren Bestandteil der affektiven Identitätsarbeit im Interview darstellen. Die Sexarbeitenden reklamieren im Interview eine widerständige und positive Identität, indem sie antizipierte oder affektiv gespürte Ressentiments der Interviewerin managen und dabei teilweise selbst Ressentiments produzieren. Unter Bezugnahme auf emotionssoziologische Arbeiten argumentieren wir, dass die Rekonstruktion von emotionalen Dynamiken im Interview notwendiger Teil einer ungleichheitssensiblen interaktionistischen Interviewforschung sein sollte.
Centile Reference Curves of the SLOfit Physical Fitness Tests for School-Aged Children and Adolescents
Authors: Blagus Rok , Jurak Gregor , Starc Gregor , Leskošek Bojan
Published: June 2022

Blagus, R, Jurak, G, Starc, G, and Leskošek, B. Centile reference curves of the SLOfit physical fitness tests for school-aged children and adolescents. J Strength Cond Res 37(2): 328–336, 2023—The study provides sex- and age-specific centile norms of Slovenian children and youth. Physical fitness was assessed using the SLOfit test battery on population data, including 185,222 children, aged 6–19 years, measured in April and May 2018. Centile curves for both sexes and 12 test items were constructed using the generalized additive models for location, scale, and shape (GAMLSS). Boys generally achieved higher scores in most of the physical fitness tests, except in stand and reach, but this was not consistent throughout childhood and adolescence, nor did it pertain to the entire range of performance. Girls outperformed boys in the arm-plate tapping test throughout childhood; the poorest performing girls outperformed the poorest performing boys in the 600-m run, 60-m dash, backward obstacle course, and standing broad jump. The shapes and trends of physical fitness curves adequately reflect the effects of growth and development on boys' and girls' physical performance. Comparing the existing reference fitness curves showed that Slovenian children and adolescents display higher fitness levels than their peers from other countries. This study provides the most up-to-date sex- and age-specific reference fitness centile curves of Slovenian children, which can be used as benchmark values for health and fitness monitoring and surveillance systems.
Perimortem and postmortem caesarean section: a systematic review
Authors: Contreras María J.V. , González Mariana G.P. , Reyes Francisco A.A. , Morales Fernando Y.R. , Zerón Hugo M.
Published: June 2022

Rationale: Perimortem caesarean section (PMCS) is an emergency procedure performed in pregnant women over 20 weeks of gestation with cardiac arrest, in order to save the mother and the foetus, or only one of them.
The objective of the review was to present clinical traits and evaluate survival of mothers and newborns as well as the complications following PMCS.
Materials and methods: A systematic review between March and May 2021 was performed using the PRISMA method with the terms "perimortem caesarean section" "postmortem caesarean section", "maternal cardiac arrest", "perimortem caesarean section "AND "case report" "postmortem caesarean section" AND "case report".
Results: 23 papers from 12 countries with 39 cases were counted. Of the total sample, 17.94% of the mothers survived and of these, 42.85% had neurological complications. Of 39 newborns counted, 69.23% survived, 28.20% died and in 2.56% the information was missing. 30.76% of the cases followed the five-minute rule and 56.41% required 6 or more minutes, 12.82% did not specify time.
Conclusion: The results of this analysis demonstrated higher mortality in women who had a cardiac arrest during pregnancy related to the neonates who survived. The possibility of performing PMCS should neither be ruled out even if the established five-minute time frame has passed, nor should time be invested in verifying foetal viability.
BPD Empowerment Program in Optimizing Village Financial Implementation (Perspective Law No. 6 of 2014)
Authors: Maharani Anggun Meinanda
Published: June 2022

Village government played an important role because it is considered as a basic element that directly interacts with the society and the policy or decision issued felt by the society directly. The issues studied were how is the BPD empowerment in optimizing village financial implementation as perspective Law No.6 of 2014? And how is the model of BPD empowerment in optimizing village financial implementation as perspective Law No.6 of 2014? The results showed that (1) BPD empowerment of Pringsari village is not optimal in conducting village finances related to activities in Pringsari village, (2) The model of BPD empowerment to the society has not been held optimally and still not transparent. The conclusion of the BPD empowerment in optimizing village financial implementation Pringsari village is not optimal yet. The model of BPD empowerment in Pringsari village that found is the achievement of APBDes planning process. Suggestion for the villager head and BPD in Pringsari village is realize the roles, jobs, functions and positions respectively.
The Implementation of Bureaucratic Reform Pillars in Increasing Taxpayer Compliance at Semarang Tax Service Office
Authors: Suwandoko Suwandoko , Rodiyah Rodiyah
Published: June 2022

Semarang City Tax Office which has the main task to collect the tax revenue in the context of national development, then the Semarang Tax Office Associate implemented bureaucratic reform pillars in improving tax compliance. This paper examined the compliance of taxpayer in the theory of bureaucratic reform. The paper emphasized that the urgency of the implementation of bureaucratic reform pillars at the Semarang Tax Office, which consists of philosophical, sociological and juridical aspects. The implementation of bureaucratic reform pillars in improving taxpayer compliance at Semarang Tax Office was examined by the implementation model of bureaucratic which influences the bureaucratic reform pillars, which indicates that taxpayer compliance level is less than optimal. The obstacles were employees who are less than optimal in the field of taxation and taxpayers who are less obedient in payment and tax reporting. The efforts did through the socialization of the bureaucratic reform pillars implementation to employees and taxpayers to improve taxpayer compliance and tax revenue.