bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution and solvent-exposure of Hsp70 chaperone binding sites across the E. coli proteome
Authors: Cavagnero Silvia , Chen Xi , Hutchinson Rachel B.
Published: October 2022

Many proteins must interact with molecular chaperones to achieve their
native folded state in the cell. Yet, how chaperone binding and
binding-site characteristics affect the folding process is poorly
understood. The ubiquitous Hsp70 chaperone system prevents
client-protein aggregation by holding unfolded conformations or by
unfolding misfolded states. Hsp70 binding sites of client proteins
comprise a nonpolar core surrounded by positively charged residues.
However, a detailed analysis of Hsp70 binding sites on a proteome-wide
scale is still lacking. Further, it is not known whether proteins
undergo some degree of folding while chaperone bound. Here, we begin to
address the above questions by identifying Hsp70 binding sites in 2,258
E. coli proteins. We find that most proteins bear at least one
Hsp70 binding site and that the number of Hsp70 binding sites is
directly proportional to protein size. Aggregation propensity upon
release from the ribosome correlates with number of Hsp70 binding sites
only in the case of large proteins. Interestingly, Hsp70 binding sites
are more solvent-exposed than other nonpolar sites, in protein native
states. Our findings show that the majority of E. coli proteins
are systematically enabled to interact with Hsp70 even if this
interaction only takes place during a fraction of the protein lifetime.
In addition, our data suggest that some conformational sampling may take
place within Hsp70-bound states, due to the solvent exposure of some
chaperone binding sites in native proteins. In all, we propose that
Hsp70-chaperone-binding traits have evolved to favor Hsp70-assisted
protein folding devoid of aggregation.
Adult High-Grade Head and Neck Cutaneous Rhabdomyosarcoma Misdiagnosed as Low-Grade Atypical Fibroxanthoma on Initial Pathology: A Case Report and Review of Diagnostic Considerations
Authors: Sims Jake , Walters Claire , Pokharel Ashbita , Korkigian Shant
Published: October 2022

Background: Adult head and neck rhabdomyosarcoma (AHNRMS) is an
exceedingly rare soft-tissue sarcoma. We describe a case of AHNRMS that
was initially misdiagnosed as atypical fibroxanthoma (AFX). Methods: A
61-year-old male with a history of cutaneous squamous cell carcinoma
(cSCC) of left face status post definitive radiation presented with a
history of rapidly enlarging masses on the left face and nose. Patient
had three large, exophytic masses on the left midface with limited local
invasion. Initial pathologic evaluation revealed atypical fibroxanthoma
(AFX). Results: Final histopathological and immunohistochemical
evaluation after surgical resection of the specimen revealed high-grade
cutaneous rhabdomyosarcoma. Patient underwent adjuvant chemoradiation
therapy. Conclusions: Soft-tissue sarcomas have considerable overlap in
histopathologic presentation, and our case highlights the importance of
a thorough immunohistochemical evaluation. This case contributes to the
current limited body of literature on cutaneous AHNRMS as well as
radiation-associated sarcomas of the head and neck (RASHN).
Evisceration in a thoroughbred gelding following application of a topical chemotherapy agent for the treatment of sarcoids.
Authors: Baldwin Alexandra , Mair Tim , Busschers Evita
Published: October 2022

This report describes the evisceration of the jejunum following acute
dehiscence of the abdominal wall in an 18 year old gelding which had
undergone treatment for suspected sarcoids on the ventral abdomen with a
topical caustic/chemotherapy agent 6 weeks previously. The sarcoid
lesions appeared to be responding appropriately to the topical therapy
until the day of presentation. The jejunum was safely contained in an
abdominal bandage and the horse underwent emergency referral before
immediate anaesthesia and further assessment. The horse was euthanased
at the owners’ request following a guarded prognosis.
Antimicrobial activity bovine bone scaffolds impregnated with silver nanoparticles on bacterial and fungal biofilm -- in vitro study
Authors: Dantas Leticia Ramos , Kraft Letícia , Gonçalves Geiziane Aparecida , Ribeiro Victoria Stadler Tasca , Witt Maria Alice , Carneiro Everdan , Tuon Felipe Francisco
Published: October 2022

Introduction: Silver nanoparticles have been extensively
investigated in dental and orthopedic materials. However, the
impregnation of bone graft with silver nanoparticles has been poorly
investigated. Objectives: The aim of this study was to evaluate
the in vitro antibiofilm activity of a bovine bone impregnated with
silver nanoparticles. Methods: Bone scaffolds from cancellous
bovine femur were used for the tests and impregnated with silver
nanoparticles (50nm) by physical adsorption. Silver nitrate minimal
inhibitory and bactericidal concentration were performed
Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans,
Enterococcus faecalis, Acinetobacter baumannii, and Escherichia
coli. Disc diffusion tests for silver nanoparticles susceptibility and
quantification of biofilm production on plate and bone with sessile cell
count were also performed. Results: All pathogens were
susceptible to silver with low minimal inhibitory concentration (0.25 –
4 mg/L). The scaffold impregnated with silver nanoparticles presented a
significant reduction in the biofilm cells for all microorganisms with a
reduction of more than 3 logs in colony forming units count.
Conclusion: Bone scaffolds impregnated with silver
nanoparticles can significantly reduce biofilm, and it can be a
strategical material to be used as an implant for different approaches.
Implementation of a Centralized Pharmacovigilance System in Multi-Country European Clinical Trials: Points to Consider for Academic Sponsors and Lessons Learnt from EU-Response and Connect4Children Consortia
Authors: Terzić Vida , Levoyer Léa , Figarella Mélanie , Bigagli Elisabetta , Mercier Noémie , Gastines Lucie de , Gibowski Severine , Trøseid Marius , Demotes Jacques , Olsen Inge , Hites Maya , Ader Florence , Lopez José Arribas , Mentré France , Espérou Hélèhe , Costagliola Dominique , Røttingen John-Arne , Poissy Julien , Rozé Jean-Christophe , Warris Adilia , O'Leary Jackie , Fernandes Ricardo , Assoumou Lambert , Hankard Régis , Turner Mark , Yazdanpanah Yazdan , Diallo Alpha
Published: October 2022

Setting-up a high quality and efficient pharmacovigilance (PV) system in
multi-country clinical trials can be more challenging for academic
sponsors than for industrials. Generating high-quality safety data,
compliant with legal and regulatory standards such as European or World
Health Organization (WHO), places special requirements on the PV system.
The scenario becomes more complicated when dealing with multi-country
European clinical trials where heterogeneity on safety process can be
encountered. Some Sponsors face these challenges are even more difficult
for pediatric trials. A possible solution to ensure that the safety of
all participants is equally guaranteed and the PV system fulfills all
regulations could be to set up a centralized PV system. This paper
introduces the key points to consider when implementing and organizing
such system in multi-national European clinical trials. It is based on
the Inserm-ANRS MIE pharmacovigilance department’s experience and aims
to harmonize and anticipate the needs, in particular by implementing
safety procedures and a network of local safety officers. This system is
very useful to respond to the challenges of a European clinical trial,
notably when considering the complexity of local safety requirements of
each country, signal management and the specificities of paediatric
regulation.
Versatile Education Domains of Schools, Colleges and Universities
Authors: Shehzadi Tabinda , Polak Dan , Fleming Shan
Published: October 2022

Day to day life has become changed after the wide-spreading adaptability of AI Researchers and AI scientists are making their unstinting efforts to make human life more comfortable and technologically advanced by using AI tools and techniques. Sustainable education is an approach of aiming to establish the sustainability act in students, and communicate the values among schools, colleges and communities the values and motivations future-in one’s own life, in their communities, and on a worldwide platform.Along with I.C.T. students, their fresher professionals also need an intelligent system that can understand each professional’s learning needs and help them excel in their skills.
PORÓWNANIE ROZWOJU SPOŁECZNO-GOSPODARCZEGO KRAJÓW AFRYKI
Authors: Kompa Krzysztof , Witkowska Dorota
Published: October 2022

Rozwój społeczno-gospodarczy jest procesem złożonym, który należy rozpatrywać wielowymiarowo. Jednak wskaźniki szacowane przez ONZ mają charakter globalny i nie są dostatecznie czułe dla porównań regionalnych. Celem pracy jest skonstruowanie miar rozwoju społeczno-gospodarczego dla krajów Afryki i zbadanie ich przydatności. Wykorzystano odległości taksonomiczne i zmienne opisujące 8 różnych kategorii jakości życia i poziomu rozwoju. Kraje pogrupowano w jednorodne klasy. Potwierdzono stosowalność proponowanego podejścia przez porównanie z innymi miarami konstruowanymi dla Afryki.
Off-design flow analysis of cogeneration steam turbine with real process data
Authors: Strusnik Dusan , Kustrin Igor , Avsec Jurij
Published: October 2022

This paper presents the concept of reconstruction of the existing coal-fired
combined heat and power plant to comply with new European environmental
policies. The existing coal-fired boiler will be replaced by two new dual
pressure heat recovery steam generators, which will utilize the exhaust gas
heat from two new gas turbines. The steam from the heat recovery steam
generators will be fed to the existing steam turbine. After the
reconstruction, the nominal turbine inlet steam mass-flow of 40 kg/s will be
reduced to 30 kg/s. During periods of low heat demand, only one gas turbine
and one heat recovery steam generator will be in operation and the live
steam mass-flow may drop even to 12 kg/s. Prior to the reconstruction,
dedicated tests of the existing steam turbine were carried out using the
steam from the existing coal-fired boiler. The goal of the test was to
verify the viability of operation with such an extremely low mass-flow. The
results of tests show that such operation is possible but inefficient from a
power generation point of view. Besides this, the turbine control algorithm
needs to be accommodated to this extreme operating regime and additional
measures like displacement of the extraction points and steam cooling will
be required to control the temperature of the steam extractions. The novelty
of this paper is using real pre-reconstruction process data for the
assessment of feasibility and efficiency of the post-reconstruction
operation of a combined heat and power turbine.
Radiant Exitance of Old, New, and Damaged LED Light Curing Units
Authors: Imbery TA , Bergeron SY , Boyle J
Published: October 2022

Purpose

This study aimed to determine the radiant exitance of new, damaged, and 16-year-old light-curing units (LCUs) with and without infection control barriers, and before and after removal of any debris.

Methods and Materials

Old LCUs consisted of 62 SmartLite iQ2 lights (Dentsply Sirona, York, PA). New LCUs consisted of 58 SmartLite Focus (Dentsply Sirona) and 58 Valo Grand (Ultradent, South Jordan, UT, USA) LCUs. Each LCU was examined for damage and debris on its tip. A handheld radiometer (CheckUp with BlueLight Analytics app, Halifax, Nova Scotia, Canada ) was used to measure the radiant exitance using a 10-second exposure time. Measurements were made with and without infection control barriers. If debris was present, the radiant exitance was measured before and after removal of debris with and without the barriers. All measurements were repeated three times. The means of the measurements were used for statistical analyses, which consisted of paired t-tests, analysis of variance (ANOVA), and Tukey post-hoc analyses conducted with a 0.05 level of significance.

Results

Infection control barriers significantly reduced the radiant exitance of all LCUs, ranging from 4.35% to 6.91% depending upon the LCU and the presence of debris or damage. Clean undamaged SmartLite Focus (907 mW/cm2) and Valo Grand (Ultradent) LCUs (883 mW/cm2) with barriers had statistically higher radiant exitance than older clean undamaged SmartLite iQ2 (Dentsply Sirona) LCUs (719 mW/cm2) with barriers. All LCUs exceeded the recommended 400 mW/cm2 radiant power to cure 2 mm of Filtek Supreme Ultra shade A2 composite resin (3M ESPE, St Paul MN, USA).

Conclusion

Infection control barriers, debris, damage, and age all significantly reduced radiant exitance of the lights.
METHOD OF MACROMICROSCOPIC PREPARATION TO DETERMINE THE FETAL ANATOMICAL VARIABILITY OF THE STRUCTURES OF THE ANTERIOR SHOULDER AREA
Authors: Koval O.
Published: October 2022

It is known that the anterior shoulder region is characterized by unique structural features and anatomical relationships that play an important role in the functioning of the shoulder. Understanding the topography of the bones, ligaments, muscles, nerves, and vessels of the anterior shoulder region is necessary to eﬀ ectively diagnose shoulder pathology, particularly with dysfunctions of various genesis and trauma. Examination of a patient with complaints of shoulder pain, depending on the degree of complexity, requires the use of additional research methods, the basis of which is knowledge of anatomical landmarks.The clinical value of using the algorithm for anatomical preparation of fascia, muscles, lymph nodes, blood vessels, and nerves of the anterior shoulder area in the practice of a surgeon allows for to prevention of their injury during complex surgical interventions.The study aimed to improve the technique of sequential preparation of fascia, muscles, vessels, and nerves of the anterior shoulder region in human fetuses to obtain standard results suitable for comparison in the age aspect.The study of fetal anatomy of the structures of the anterior shoulder area was carried out on 26 preparations of human fetuses of 4-10 months with the help of macromicroscopic dissection.On the anterior- medial surface of the shoulder, the landmark that determines the position of the vascular and nerve trunks is the medial edge of the biceps brachii muscle and its tendon. During macromicroscopic dissection of fetuses of diﬀ erent ages, anatomical variability of the muscles of the anterior group of the shoulder, as well as vascular and nervous formations of the anterior shoulder area, was established. The obtained data on the technique of preparing the structures of the anterior shoulder area and the topographic and anatomical landmarks of its vascular and nervous formations in the fetal period of ontogenesis will contribute to the justiﬁ cation of rational diagnostic and therapeutic techniques in fetal surgery.
STUDY OF ANATOMICAL FEATURES OF INTERNAL FEMALE GENITAL ORGANS IN NORMAL AND PATHOLOGICAL CONDITIONS FOR ACQUISITION OF PRACTICAL SKILLS
Authors: Semenіak А. , Nitsovych І. , Bodnaryuk O. , Khlunovska L.
Published: October 2022

The article provides basic information about the peculiarities of mastering practical skills in the discipline «Obstetrics and Gynecology» by students of 4, 5 courses of the specialty «Medicine» in terms of distance learning and in classical learning conditions. It is established that the acquisition of practical skills depends on the knowledge of the topographic anatomical location of the internal genitals in normal and pathological conditions, their age, including in children and adolescents. The ways of overcoming the problem of mastering practical skills in the conditions of distance learning are considered, the results of implementation are given.
Health Services Avoidance and Self-Treatment During the COVID-19 Pandemic: Evidence from rural India
Authors: Savitha Basri , Shelley Adithya , Kumar K Naveen
Published: October 2022

Objectives: This paper is one of the first studies that identifies factors that inhibit access to healthcare services and healthcare-seeking behaviour (HCSB) in rural India during the COVID-19 pandemic.
Methods: The data source was the household sample survey of the World Bank on ‘COVID-19-Related Shocks in Rural India 2020, Rounds 1-3’. Binomial and multinomial regression analysis was carried out to estimate the determinants of health care avoidance and HCSB.
Results: Families belonging to low consumption quartiles not only delayed obtaining health care but also underutilized formal health resources at public and private facilities. The majority of non-agricultural households, as well as those that reduced their consumption during the outbreak, were forced to self-medicate through pharmacies. Family planning, immunization, child growth monitoring, and routine medical check-ups were among the services that were not availed during the pandemic.
Conclusion: The findings of this study emphasize the need of removing financial obstacles to care during the COVID-19, as well as the importance of child-related care continuity (child development monitoring, antenatal care, and immunization) and routine check-ups.
Association Between Secure Attachment Style and Subjective Well-being: Examining the sequential mediation effects
Authors: Mittal Ella , Rani Tamanna
Published: October 2022

Attachments are an integral element of the human experience from birth to death. Early experiences with caregiver and adult attachments are crucial for human emotional and cognitive development and it is a strong basis for mental health and psychological adjustment. Despite this, little research on the relationship of these attachments has been undertaken on subjective well-being.  
This study intended to investigate the relation of secure attachment style with subjective well-being through serial mediation effect of self-esteem and emotional intelligence. Process macro version 3.4 in SPSS 23 and AMOS 21.0 were used to evaluate survey data of 266 respondents.
The findings of the study revealed that secure attachment style play a significant role in enhancing the subjective well-being of people and a positive significant relation was found between them. Also, this relationship was mediated by both self-esteem and emotional intelligence which supports the serial mediation model. Hence, the results exhibit that secure attachment style predicts self-esteem and emotional intelligence, which in turn influences the subjective well-being of persons. Furthermore, both direct and indirect effects were statistically significant.
Theoretical and practical implications are discussed based on the findings of the study.
Evil And The Problem Of Impermanence In Medieval Japanese Philosophy
Authors: Nagasawa Yujin
Published: October 2022

Abstract. The problem of evil is widely considered a problem only for traditional Western monotheists who believe that there is an omnipotent and morally perfect God. I argue, however, that the problem of evil, more specifically a variant of the problem of evil which I call the ‘problem of impermanence’, arises even for those adhering to the philosophical and religious traditions of the East. I analyse and assess various responses to the problem of impermanence found in medieval Japanese literature. I argue that the only response that is potentially satisfactory requires supernaturalism. I conclude, therefore, that the problem of impermanence is a unique problem posing a greater challenge to naturalists than to supernaturalists.
Hermitism and Impermanence
Authors: Morioka Masahiro
Published: October 2022

Abstract. Nagasawa argues that only transcendentalism can constitute a potentially successful response to the problem of impermanence. In this review, I argue that Chōmei’s hermitism can be another realistic strategy to respond to it. Chōmei lived in a small house in the remote mountains and interacted with the surrounding nature. His lifestyle is considered a good example of reconciling one’s finite life with the impermanence of the world and human sufferings. I conclude that Nagasawa’s interpretation of hermitism might be one-sided.
Reply To Oliver Wiertz, Masahiro Morioka And Francesca Greco
Authors: Nagasawa Yujin
Published: October 2022

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Application of Principle of Power Deliveries Settlement for 330 KV Electric Power Network
Authors: Silaghi Helga , Coroiu Laura , Gergely E. , Măgdoiu Liliana Doina , Romocea M. , Ivan R.
Published: October 2022

Distribution of active and reactive power between consumers raises the problem of participation of each power station in supply of loads and determining flows of power from each generator trough branches of an electric power network. Interest of this problem mainly is chosen by the development of open access market in power systems. In this paper a method is reviewed of determination of settlement factors, which is based on finding the trace in oriented graph, and allows, with the number of cycles equal with the number of generator nodes, determine the part of active power, which flow from each generator through branches of electric network to load node.
Ranking of the primary threats to the national security of the Russian Federation
Authors: KRUPNOV Yurii A.
Published: October 2022

Subject. This article deals with the issues of strengthening the sovereignty of the Russian Federation in the context of aggravation of relations with Western countries. Objectives. The article aims to develop a methodology for the rapid and efficient identification, ranking and assessment of threats to national security characterized by the maximum potential for damage to the Russian Federation. Methods. For the study, I used a causal analysis, analogy approach, and the method of expert assessment. Results. The article confirms that the major threat to the national security of the Russian Federation is the country's drawing into wars and armed conflicts. Human military losses and casualties, a decrease in incomes of the population, an increase in the flow of migrants and refugees, permanent psychological stress should also be regarded as a high-ranking threat. Conclusions. The proposed methodology for ranking threats simplifies the development of the national security status indicators.
Developing a methodology to assess the effectiveness of implementation of strategic area digital transformation of key sectors of the economy, social sphere, and public administration of the Russian Federation subjects
Authors: LOBKOVA Elena V.
Published: October 2022

Subject. This article explores the transformational effects of the transition to a digital economy, their impact on the quality and standard of living.
Objectives. The article aims to identify areas that require additional study in order to increase the efficiency of the process of digitalization of the social sphere, sectors of the economy, and the system of public administration.
Methods. For the study, we used the method of index numbers.
Results. The article proposes a sequence of evaluation procedures that can help obtain a consolidated integral characteristic of the effectiveness of the implementation of strategic plans for the digital transformation of the regions.
Conclusions. Adjusting strategic plans and updating regional projects based on the experience of digitalization and adequate assessments of success and failure in this process is a promising direction.
Analyzing the changes in the Chuvash Republic's budget in the context of the development strategy
Authors: SMIRNOV Valerii V.
Published: October 2022

Subject. This article analyzes the economic situation of the Chuvash Republic.
Objectives. The article aims to identify the sectors of the economy of the Chuvash Republic that have the maximum potential for development.
Methods. For the study, I used the methods of statistical, neural network, and cluster analyses.
Results. The article finds that due to an integrated approach to digital transformation, the Chuvash Republic can become a center for the development of information and communication technologies.
Conclusions. The results of the study can be used when developing strategic planning documents at the regional level.
Improving the financial management model for the Russian Federation municipalities: The Surgutsky Municipal District, Khanty-Mansi Autonomous Okrug – Yugra case study
Authors: MATAEV Veniamin V. , Yuliya V. MARKOVA Yuliya V. , KUZ'MINA Dina V. , MEL'NIKOVA Elena P. , KHUTOROVA Natal'ya A.
Published: October 2022

Subject. This article deals with the issues of financial support for the activities of local self-government bodies.
Objectives. The article aims to optimize the methods of financial management at the municipal level.
Methods. For the study, we used logical and statistical analyses.
Results. The article presents an author-developed model of financial management for municipalities, which can help monitor the achievement of indicators of national projects of Russia, optimize the activities of executive and administrative bodies of local self-government, and spend local budget funds effectively.
Conclusions. The proposed solutions can be used in the practice of local self-government bodies of municipal and urban districts.
El sistema político vasco. Cuatro décadas construyendo una cultura de estabilidad en un entorno de fragmentación
Authors: Casal Oubiña Daniel
Published: October 2022

El presente paper analiza como durante más de cuatro décadas las instituciones de autogobierno del País Vasco han construido un sistema político estable en el marco de un entorno de fragmentación política de tipo ideológico e identitario. Para estudiarlo el artículo construye un marco analítico que parte de la definición teórica de los elementos principales que definen los modelos de democracia a partir de la clasificación de Lijphart (2016) que se complementa con un análisis de las características del Parlamento Vasco, como institución central del sistema y el modelo de relaciones con el Gobierno en tres dimensiones: el impacto de la proporcionalidad del sistema electoral en el sistema de partidos resultantes; el grado de concentración del poder ejecutivo y las relaciones Gobierno-Parlamento en el periodo 1980-2021.
Alcance de la afectación y desafectación del dominio público y sus efectos sobre el derecho de reversión
Authors: Iglesias González Felipe
Published: October 2022

La mecánica de la afectación y desafectación para distinguir los bienes patrimoniales de los demaniales se encuentra en evidente crisis. Frente a la legislación y doctrina que continúan afirmando la necesidad de la afectación y desafectación formal, una nítida jurisprudencia enfatiza tanto la necesidad de afectación material y como la existencia de desafectación tácita. Esta línea jurisprudencial tiene un evidente efecto en el ejercicio del derecho de reversión en supuestos expropiatorios. De esta forma, una línea jurisprudencial, ciertamente minoritaria, reconoce el derecho de reversión bien cuando se demuestra la falta de afectación material, bien cuando se acredita la existencia de una desafectación tácita. Sin embargo, una jurisprudencia mayoritaria supera este análisis, haciendo hincapié, por ejemplo, en el cumplimiento de la finalidad urbanística conjunta.
The Practice of Lviv District Court and the Lviv Court of Appeals in Cases on Medical Practitioner’s Malpractice in 1919–1939
Authors: Lytvynenko A. A.
Published: October 2022

The legal aspects of healthcare in the Lviv oblast during the time it was under the reign of Second Rzeczpospolita Polska (1919–1939) remain underinvestigated. Alongside with the rise of lawyers’ and scholars’ attention to the aspects of history of medical law and the protection of patients’ rights, the question of disputes in the sphere of healthcare in various time periods (i.e. medical practitioners’ malpractice, lawsuits against hospital sickness funds, as legal entities because of negligence of the hospital sickness fund physicians, occurring within the provision of medical treatment, or conducting medical treatment without the patient’s consent etc.) has undoubtedly risen. The history of medical law of Ukraine remains underinvestigated. The practice of the courts operating in the Lviv oblast in 1919–1939 in cases on medical practitioners’ malpractice has yet not become the object of the research of Ukrainian scholars to date, analogically to the period, when the Lviv oblast was under the reign of the Austrian-Hungarian Empire in 1867–1918, or even in earlier times. The practice of the courts of the Lviv oblast in cases on medical practitioners’ malpractice in the period of 1919–1939 illustratively displays that civil lawsuits relating to medical malpractice were not rare ones. What is more, the court practice of those days featured criminal trials against medical practitioners for committing severe negligence, or illegitimate abortions. For a more complex understanding of medical practitioners in Austrian-Hungarian law by the reader, we will provide a brief explanation relating to it as well, in particular, on basis of those-days case law.
The Last Years of the Reign of the Bosporan King Fofors in the Context of the Internal Political Struggle in the Roman Empire during the Tetrarchy
Authors: Yartsev Sergey  Vladimirovich
Published: October 2022

The object of the study is the history of the ancient civilization of the Northern Black Sea region, as part of the Roman world during the early dominant period. The subject of the study is the history of the Bosporan Kingdom in the last years of the reign of King Fofors in 303/304–309/310, in the context of relations with the Roman Empire during the new system of government – tetrarchy. The author examines in detail such an aspect of the topic as the internal political struggle in the Roman Empire of that time and its impact on the events that took place on the Bosporus. Particular attention is paid to the political struggle of two opposing factions for supreme power in the Bosporan Kingdom at the specified time. The main conclusions of the study are related to the factors of the strengthening of the influence of the Roman Empire on the northern periphery of the ancient world in the last years of the Bosporan king Fofors. It is obvious that during this period, virtually any conflict in the internal life of the empire, to one degree or another, exerted its influence on the course of the history of the Bosporan state. Thus, the fall of the power of Fofors on the Bosporus became possible only after the Bosporan king lost Roman support, first Diocletian, and then Galerius. In 309/310, Fofors was replaced by a new tsar, Radamsad, who may have been a protege of Maximin II Daza, who was actively preparing a plot to seize supreme power in the empire just during these years. The main contribution of the author to the study of the topic is the first revealed pattern of the history of Bosporus during the reign of Fofors. The novelty of the research lies in the fact that for the first time in historiography, this tense moment of Bosporan history is viewed through the prism of the internal political struggle in the Roman Empire during the tetrarchy (293-313).
Opções terapêuticas da doença hemorroidária: uma revisão integrativa
Authors: Pereira Ellisa Amorim , Silva Lais Gomes , Mascarenhas Laize Andrade , Moura Letícia Coutinho , Correia Jennifer Rodrigues , Santos Cinara Dourado Pereira Correia
Published: October 2022

Objetivo: Discutir acerca das técnicas utilizadas nos tratamentos convencionais para Doença Hemorroidária (DH), correlacionando as estratégias existentes entre as técnicas de modo a qualificar os melhores estudos quanto ao pós-operatório e a melhor qualidade de vida do paciente após cirurgia. Métodos: Foi realizada uma revisão integrativa de artigos, com busca utilizando a base de dados virtual PubMed. o estudo teve como inclusão artigos de comparação entre métodos e técnicas cirúrgicas de DH e artigos que expuseram uma técnica, as quais abordaram prognóstico cirúrgico associado a sinais e sintomas do paciente frente a realização dessas. Resultados: Foram recuperados 11 trabalhos que havia comparação multimodal de técnicas. O número total de pessoas pesquisadas nos trabalhos foi de 2071 pessoas, sendo 819 mulheres e 1046 homens. A idade variante do estudo foi de 18 anos a 59 anos, sendo a média de idade de 38 anos. O número de pessoas que realizaram Hemorroidopexia Circular Mecânica (PPH) foi de 612 pessoas, Considerações finais: As técnicas de cirurgia convencional têm melhores resultados a longo prazo. Apesar de bons resultados no período pós-operatório imediato, PPH e Dearterialização Hemorroidaria Transanal (THD) não apresentam resultados seguros a longo prazo.
Análise das características da Adenomiose e Miomatose Uterina: uma revisão narrativa
Authors: Santos Mila Schiavini Beiriz , Fraga Anna Luiza Guimarães , Marinho Manuela de Oliveira , Trambaioli Vanessa Silva , Santos Karina Sousa dos , Venito Lucas da Silva , São Roque Mayara Affonso , Aranda Osvaldo Luiz
Published: October 2022

Objetivo: Analisar as características da Adenomiose e da Miomatose Uterina. Revisão bibliográfica: Os sangramentos uterinos anormais são queixas ginecológicas comuns nos consultórios de ginecologia, podendo ter como causas a Adenomiose Uterina ou a Miomatose Uterina. Essas doenças podem atingir mulheres de todas as idades, sendo atualmente cada vez mais diagnosticadas em mulheres jovens. Ambas as patologias possuem difícil diagnóstico por terem seus sintomas muito semelhantes a outras doenças, entretanto, podem também ser diagnóstico diferencial uma da outra. Sintomas como hipermenorreia, infertilidade, dor e anemia são comuns de serem encontrados nessas disfunções, afetando a qualidade de vida das mulheres fisicamente e emocionalmente. Considerações finais: A miomatose uterina e a adenomiose possuem inúmeras etiologias que ainda não foram bem difundidas, ademais, é necessário buscar um rápido, eficaz e conclusivo diagnóstico para realizar o tratamento adequado com o intuito de melhorar a vida das mulheres que sofrem com essas doenças. A rápida identificação da doença e tratamento tem como benefício evitar traumas, medicações e procedimentos cirúrgicos desnecessários que ocorrem quando não se tem um diagnóstico correto e preciso.
Методичні поради до підвищення точності метакогнітивного моніторингу навчальної діяльності в здобувачів вищої освіти
Authors: Августюк Марія
Published: October 2022

Методичні поради призначені для здобувачів вищої освіти, викладачів та психологів, а також усіх суб’єктів пізнавальної діяльності, які працюють з інформацією. У порадах висвітлено теоретичний аспект вивчення чинників точності метакогнітивного моніторингу, окреслено можливі шляхи підвищення точності метакогнітивного моніторингу навчальної діяльності в студентів, зокрема, наведено приклади практичних методів підвищення точності метакогнітивного моніторингу у вигляді опитувальників та тренінгових занять
Методичні поради до підвищення точності метакогнітивного моніторингу навчальної діяльності в здобувачів вищої освіти засобами емоційного інтелекту
Authors: Августюк Марія
Published: October 2022

Методичні поради призначені для здобувачів вищої освіти, викладачів та психологів, а також усіх суб’єктів пізнавальної діяльності, які працюють з інформацією. У порадах висвітлено теоретичний аспект вивчення взаємозв’язку емоційного інтелекту з основними характеристиками метапізнання в навчальній діяльності студентів, окреслено можливі шляхи підвищення точності метакогнітивного моніторингу навчальної діяльності в студентів засобами емоційного інтелекту.
The Impact of Minor Injury Cases at a Level I Trauma Center: A Retrospective Observational Study
Authors: Kumar Vivek , Alam Junaid , Theepan R , Kumar Nitish , Kumar Subodh , Gupta Amit , Sagar Sushma
Published: October 2022

Introduction. Few studies have been done on the burden of minor injuries on trauma centers. Patients with minor injuries require care in the ED, which diverts staff time and resources from patients with more serious injuries and which can sometimes overwhelm the functioning of even the best trauma facility. Objective. This study was conducted to assess the burden of minor trauma and thus emphasize the need to develop further management protocols. Methods. A retrospective observational study was conducted at a level I trauma center for a period of 1 month (February 14, 2020 through March 14, 2020) to assess the burden of minor injuries at that facility. The study population included all patients who required ED care for minor injuries. Data collected included age, sex, time of presentation, anatomical region involved, and interventions done. Results. Of the 3293 patients, 1255 were triaged as green. Seven hundred ninety-one patients with 849 injuries required ED intervention in the minor operation theater. Of the 791 patients, most were male (84.32%), and 61.4% were aged 21 to 40 years. In decreasing order, the most common modes of injury were road traffic injuries (68.4%), fall (15%), and interpersonal violence (13.8%). Maxillofacial injuries were present in 26.15% of patients, 25.8% of patients presented with injuries to the head and neck, 24% with lower extremity injury, and 21.9% with upper extremity injury. Conclusions. The burden of minor trauma should be recognized. Knowledge of local trauma epidemiology and injury patterns is essential for trauma centers to function well. It is important that all trauma centers should have dedicated protocols in place and trained personnel to address these minor trauma cases.
The Effect of COVID-19 on the Pressure Injury Reporting Gap
Authors: Sasson Daniel , Patel Seema , Duan Kaiti , Signore Corinne , Hsia Henry
Published: October 2022

Responsibilities placed on nurses increased during the COVID-19 pandemic. Hospital-acquired PI monitoring was deferred in favor of more critical patient needs. It was hypothesized that a counterintuitive dip in HAPI reporting would be observed despite maximum hospital capacity across much of the United States. The electronic medical records of patients treated in the YNHH System between December 2017 and February 2021 were retrospectively reviewed to identify patients with HAPIs, defined as PIs not documented upon admission but subsequently present during the patient’s hospital stay. Paired t test revealed a significantly lower number of reported incidents mid-pandemic than during the prepandemic baseline months (P <.0001). The data in this report show interdisciplinary clinician-led teams must continue to monitor for HAPIs and congruous conditions to minimize reporting gaps and progression in PI severity despite COVID-19 pandemic-related conditions and additional related responsibilities.
Solid State Synthesis of Silver Nanoparticles Using Violuric Acid as a Novel Reducing Agent
Authors: Ahmad Amir Abdulrahman
Published: October 2022

Metal Nanoparticles (NPs) are recognized as the most attractive materials due to their distinct physical and chemical characteristics. Several physical and chemical synthesis methods have already been tested to obtain NPs of appropriate size and shape. Although the chemical-based solution methods provide NPs within a proper size and shape and can be reasonably controlled, they require a large amount of raw material including solvents, capping agents, etc., which usually lead to toxic output and waste. In this study, the author tested an easy and environmentally friendly solid-state synthesis pathway for synthesizing silver (Ag) NPs within a suitable size and shape, using a novel reducing agent. Silver carbonate (Ag2CO3) was allowed to react with Violuric acid (C4H3N3O4) as a reducing agent through a solid-state grinding method for one hour. The results confirmed that Violuric Acid can be considered a promising reducing agent that results in the formation of well-shaped spherical Ag NPs within an average particle size of about 60 nm.
Education is at the Heart of Every Human Settlement
Authors: Ike Obiora F.
Published: October 2022

Against those who question that ethical character should be considered as convincing factor of the human constitution based on empirical reasons, Obiora F. Ike gives good arguments, based on the agenda of the human development and education across the planet, to reaffirm some truth about character formation. There should be no question that simplifications, related to some sort of skepticism over the moral character, are at best purely theoretical fanciness, at worst irresponsible. Passivity in a world made of urgent challenges around education and economic inequalities is not acceptable. Our need to believe, to trust and to act in the real world, lead us to praise some dogmatism on the ground assumption that we act accordingly to our [moral] character. Education has shown us the value of developing moral character. Cross-situational consistency of integrity needs to be shared across cultures, against the impression that it opens a room for abuses, as integrity is also a social construct.
The Power of Stories
Authors: Kantert Meggy
Published: October 2022

If we want to honour Obiora’s work and the inspiration he has offered and continues to provide we cannot get past his stories. He often uses stories to exemplify ethical behaviour and the impact of unethical behaviour. Reading and retelling stories are effective teaching tools for ethical behaviour. At the same time stories can foster intercultural communication as they promote dialogue and reflection on one’s own culture. They inspire understanding and embracing diversity. This article is an invitation to rediscover the power of stories in teaching ethical behaviour.
Students’ Exposure to Common Good Ethics and Democracy Outcomes
Authors: Ugwuozor Felix Okechukwu
Published: October 2022

Following Professor Obiora Ike’s view and in particular Obiora 2012, 2013, 2017 (see reference below), the more students are exposed to ethics practice, the greater their propensity and capability to seek for ethical living. This important assumption is worth close statistical scrutiny as the author shows. Through empirical researches and the stratified sampling approach, 435 university students are randomly selected to illustrate this claim. The method used is the “Perceived Role of Ethics and Democracy Outcome Scale” (PREDOS) and a survey questionnaire used to measure exposure to common good ethics among the respondents. Descriptive analysis – tables and analysis and covariance (ANCOVA), are aimed at facilitating the analysis of the data collected in the study.  In tandem with the conclusions drawn from extant literature and works of Professor Obiora Ike, the findings, as the author see, show that exposure to common good ethics has a significant positive effect on students’ ethics practice and democracy outcomes.
Homo Novus: Learning to Being Renewed
Authors: Adamavi-Aho Ekué Amélé
Published: October 2022

This contribution anchors the topic of transformative education in the discussion of human renewal. It posits that transformative education can only be perceived as an endeavour that encompasses the whole human being and the potential of humans to change and to adopt different perspectives on seeing and being in the world. The motif of the new human being (homo novus), as per the argument presented, can serve to develop a meaningful conceptual and praxis-related framework for education. Especially when considered against the background of the debate on education serving the establishment of communities of belonging across cultures, in which ethics and values can be lived and probed.
Review of the Pilgrimage for Justice and Peace (PJP) Series
Authors: Van Rooyen Lyn
Published: October 2022

Since its 10th Assembly of Busan, 2013, the World Council of Churches (WCC) started a movement that invites us to walk with them: a Pilgrimage for Justice and Peace (PJP), a project looking to foster a debate within its members, envisaging to mark the steps to walk towards the world we want. The World Council of Churches (WCC) is the broadest and most inclusive among the many organized expressions of the modern ecumenical movement, a movement whose goal is Christian unity.
Environmental Assessment Methodology for Ocean Technologies
Authors: García Orozco Selef , Mendoza Baldwin Edgar
Published: October 2022

El presente material se enfoca en el desarrollo de una metodología de evaluación ambiental para tecnologías del océano. El diseño mecánico y los Objetivos de Desarrollo Sostenible de la Agenda 2030 se vuelven ejes rectores para realizar una evaluación ambiental integral. Se presenta la metodología establecida por las normas iso 14040-14044:2006 para el desarrollo de la evaluación ambiental con el enfoque de análisis de ciclo de vida. Asimismo, se establece un panorama general de las herramientas computacionales para el desarrollo de las evaluaciones ambientales. Además, se plantea la importancia de realizar estos estudios para la toma de decisiones en etapas de conceptualización y diseño para minimizar los impactos al medio ambiente.
Classification of Cannabinoid Spectra Using Machine Learning
Authors: Kabra Narayan , Serra Gianluca , Lozano Miguel , Tommasini Matteo , Sankaranarayanan Karthik , Agarwal Nisha Rani
Published: October 2022

Vibrational spectroscopy, encompassing Raman and Infrared (IR) spectroscopy, is a powerful technique that probes the intrinsic vibrations of a molecule, thus providing a unique chemical signature for that molecule. This information is beneficial to differentiate between two similarly structured molecules since their vibrational fingerprint will be different. In an effort to introduce an automated spectroscopic data analysis tool, we explore different Machine Learning (ML) algorithms to identify the chemical structure from the simulated Raman and IR spectra of 22 similar molecules belonging to the class of cannabinoids. In this study, we investigate the best ML approach by using representative synthetic IR/Raman data obtained from quantum chemical calculations of the selected molecular structures. We account for the experimental variability of the spectra by adding different kinds of noise and backgrounds to the simulated spectra such that they mimic experimental conditions such as fluorescence background as well as Gaussian noise. This methodology is used to setup the database to train the ML algorithms. We report the accuracy of the different ML algorithms and the time taken to process the algorithms in differentiating the cannabinoid varieties.
Is Schleyer’s Predicted All-Cis [10]Annulene an Unstable Framework?
Authors: Parmar Karnjit , Blaquiere Christa , Lukan Brianna , Gengler Sydnie , Gravel Michel
Published: October 2022

In this work we describe the synthesis of a long sought after planar [10]annulene. Remarkably, the efforts also led us to discover a completely unexpected and highly aromatic cyclopropa mono-trans[10]annulene. The parent [10]annulene (cyclodecapentaene) is non-planar and thus non-aromatic because the aromatic stabilization energy is not sufficient to overcome the strain involved in expanding CCC bond angles from the standard 120° to the necessary 144°. Interestingly, it was theorized by Schleyer (10.1021/ja953126i) that planar structures could be attained by adding cyclopropane (or cyclobutane) rings to the periphery. We opted to target the dicyclopropa[10]annulene derivative that was proposed as it was a formal cyclopropanation of our previously found stable dehydrocyclopropa[10]annulene (10.1038/s44160-022-00135-z, 10.26434/chemrxiv.14458653.v1). It was also presumed that the symmetry present within the structure would make the Kekulé structures degenerate, thus improving aromaticity substantially. However, we were uncertain if the structure would be kinetically stable and wished to attempt a synthesis to investigate it further. In this paper we describe our evolving synthetic strategy that ultimately led us to the preparation of the dicyclopropa[10]annulene. Interestingly we noted that the framework itself was rather unstable and degraded quite rapidly. We also observed that the final preparation of the desired material led to a significant side product that was identified as a cyclopropa mono-trans[10]annulene. This side product was completely unexpected and found to be more kinetically persistent than the original target.