bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Imidazo[1,2-a]pyridine Compound Reduces Cell Viability and Induces Apoptosis of HeLa Cells by p53/Bax-Mediated Activation of Mitochondrial Pathway
Authors: Yu Yang , Li Yanwen , Yang Xinjie , Deng Qiuyi , Xu Bin , Cao Hua , Mao Jianwen
Published: August 2021

Background:

Despite emerging research on new treatment strategies, chemotherapy remains one of the
most important therapeutic modalities for cancers. Imidazopyridines are important targets in organic chemistry and,
given their numerous applications, they are worthy of attention.

Objective:

The objective of this study was to design and synthesize a novel series of imidazo[1,2-a]pyridine-derived
compounds and investigate their antitumor effects and the underlying mechanisms.

Methods:

Imidazo[1,2-a]pyridine-derived compounds were synthesized with new strategies and conventional methods.
The antitumor activities of the new compounds were evaluated by MTT assay. Flow cytometry and immunofluorescence
were performed to examine the effects of the most effective antiproliferative compound on cell apoptosis. Western
blot analysis was used to assess the expression of apoptotic proteins.

Results:

Fifty-two new imidazo[1,2-a]pyridine compounds were designed and successfully synthesized. The compound,
1-(imidazo[1,2-a]pyridin-3-yl)-2-(naphthalen-2-yl)ethane-1,2-dione, named La23, showed high potential for
suppressing the viability of HeLa cells (IC50 15.32 μM). La23 inhibited cell proliferation by inducing cell apoptosis,
and it reduced the mitochondrial membrane potential of HeLa cells. Moreover, treatment with La23 appeared to increase
the expression of apoptotic-related protein P53, Bax, cleaved caspase-3, and cytochrome c at a low concentration range.

Conclusion:

The novel imidazo[1,2-a]pyridine compound, La23, was synthesized and it suppressed cell growth by
inducing cell apoptosis via the p53/Bax mitochondrial apoptotic pathway.
Explorations of ATP-Binding Cassette Transporters and Apoptosis Signal Pathways
of 2-Hydroxyanthraquinone Substituted Cyclotriphosphazenes in MCF-7 and DLD-1
Cell Lines
Authors: Yazgan Burak , Mesci Seda , Bayık Nagihan , Akşahin Maşuk , Çiftçi Gönül Yenilmez , Yıldırım Tuba
Published: August 2021

Background:

As a class with biological properties, such as anti-cancer, anti-bacterial, anti-HIV, and various
physical effects, phosphazene derivatives constitute the most striking part of inorganic compounds. Anthraquinones, on
the other hand, are a broad family of compounds with a wide variety of biological properties; the biologically active
anthraquinones have been used as valuable compounds for biochemical and pharmacological research.

Objective:

In this study, we aimed to investigate the effect of the anthraquinone substituted cyclotriphosphazene compounds
on apoptosis and drug resistance in MCF-7 and DLD-1 cells.

Methods:

In breast and colon cells, mRNA levels of multi-drug resistance genes (ABCB1, ABCC3, ABCC10,
ABCC11, and ABCG2), apoptotic genes (BAX, BCL-2, p53, and PARP), heat shock (HSP27, HSP40, HSP60,
HSP90α) and endoplasmic reticulum chaperone genes (GRP78, and GRP94) were determined by the qPCR method.
The amount of proteins of the cell cycle, HSPs, apoptosis, and related signaling pathways were measured by the membrane
array kits.

Results:

Compounds 2, 3, 4, and 7 showed the most potent results on the ATP-binding cassette genes in both breast
and colon cancer cells. These compounds have a remarkable effect on apoptotic, heat shock, and ER chaperone genes
in cancer cells. Besides, these compounds induced protein levels of pro-apoptotic pathways, leading to apoptosis by
inhibiting anti-apoptotic pathways. Also, these compounds decreased HSPs.

Conclusion:

These compounds have potential properties that eliminate drug resistance, suppress heat shock and ER
chaperone genes, and drag cells to apoptotic cell death and are notable for drug studies.
The Effects of Probiotics and Prebiotics on Gastrointestinal and Behavioural
Symptoms in Autism Spectrum Disorder
Authors: Cauli Omar , Guevara-Gonzaléz José , Guevara-Campos José , González Lucía
Published: August 2021

Background:

Autism Spectrum Disorders (ASDs) are a group of prevalent neuropsychiatric
disorders. They present a complex and unknown etiology, which in most cases includes significant
peripheral alterations outside the brain such as in the composition of gut microbiota. Because
the gut microbiota is involved in modulating the gut-brain axis, several studies have suggested that
the microbiome in the gut can modify metabolites which are able to cross the blood-brain barrier
and modulate brain function.

Methods:

We reviewed the current evidence regarding microbiota alterations in patients with ASD
and the effects of the administration of probiotics and prebiotics in these patients, both in terms of
gastrointestinal and behavioural symptoms.

Results:

Administration of a probiotic formulation containing different strains of Lactobacillus (L.
acidophilus, L. rhamnosus, and others) and Bifidobacteria had beneficial effects upon these aforementioned
symptoms and their use is recommended in a subgroup of ASD patients that present gastrointestinal
disturbances. Nonetheless, the types of gastrointestinal disturbances that most benefit
from such interventions remain to be elucidated in order to personalize the medical approaches.

Conclusion:

Recent clinical studies have shown that probiotic treatments can regulate the gut microbiota
and may result in improvements in some behavioral abnormalities associated with ASD.
Trials using prebiotic fibers or synbiotics preparations are still lacking and necessary in order to
deep in such therapeutic strategies in ASD with comorbid gastrointestinal disrturbances.
Consumo eléctrico, confort térmico e impacto ambiental de una institución educativa ubicada en el norte de Argentina
Authors: Mendoza Dora , Castro Mendoza Cecilia Inés , Mendoza Vela Pablo Alberto
Published: August 2021

El objetivo de este trabajo es conocer el consumo eléctrico de una institución educativa por el uso de equipos de aire acondicionado para el confort térmico, como también el impacto local y ambiental que genera dicho consumo. La institución se encuentra en la ciudad de Orán (Norte de Argentina), en zona bioclimática IIb (Norma IRAM 11603) y se trata de una Sede Universitaria. Para su funcionamiento dispone de 2 predios: el predio 1 se encuentra en zona céntrica y es la unidad de estudio. Aplicando diferentes técnicas e instrumentos se investiga acerca de las condiciones climáticas de la región, los aspectos estructurales y funcionales del edificio de la institución, la dinámica de la comunidad educativa y sus preferencias tecnológicas para el logro del confort térmico, el consumo eléctrico en el periodo 2013-2018 y las áreas de demanda eléctrica. Con todos los datos obtenidos y, aplicando un procedimiento basado en meses referentes, se estima el consumo eléctrico por el uso de equipos de aire acondicionado. También se analizan los impactos locales y se estima la huella de carbono por esa actividad. Los resultados más importantes son: se trata de una región muy calurosa, el aspecto estructural del edificio carece de conceptos bioclimáticos, el consumo eléctrico por el uso de equipos de aire acondicionado representa el 28% del consumo anual total del predio 1 y una emisión aproximada de 13 tnCO2eq/año, requiriendo entre 1300 y 2600 árboles para su mitigación. Resulta imprescindible implementar estrategias bioclimáticas en el edificio de la Sede Universitaria.
Evaluación del cultivo del hongo pleurotus ostreatus y de su composición nutricional en borra de café
Authors: Nieto Juárez Jessica Ivana , Cuzcano Ruiz Angel David , Reyes lópez Walter Anderson
Published: August 2021

El cultivo del hongo Pleurotus ostreatus en residuo borra de café fue estudiado, con el propósito de evaluar su potencialidad como método de tratamiento para la valorización de este residuo. Su composición nutricional fue también evaluada como un control de calidad, con la finalidad de verificar que sea un alimento con valor nutritivo y libre de sustancias tóxicas para su consumo. La influencia de la cantidad de semilla micelial en la eficiencia de producción del hongo fue investigada, obteniéndose que la cantidad adecuada de semilla micelial fue entre 10 y 20 % (g semilla/100 g sustrato húmedo) dando una eficiencia biológica de aproximadamente 60 %. El valor proteico de la seta de ostra fue de 47.3% en muestra seca, con un alto contenido de agua (~ 90 %) y bajo contenido en carbohidratos (5.4 %) y grasas (0.2 %) en muestra fresca. Los micronutrientes presentes en la seta de ostra fueron el potasio, como elemento más predominante, seguido de magnesio, calcio y sodio y en trazas tenemos al silicio, hierro, cobre y zinc en muestra seca. El contenido de cafeína fue menor de 60 µg/g en la seta de ostra.  Los resultados, por lo tanto, indican que la borra de café es un residuo potencial para el cultivo de setas de ostra (Pleurotus ostreatus), generando un alimento altamente proteico y saludable, el cual podría ser incluido en la dieta diaria, y, así, contribuir a mejorar la salud de las personas, nutrición y controlar algunas enfermedades.
Impacto de la interconexión de mercados eléctricos transfronterizos en la expansión de los parques de generación de Perú y Ecuador
Authors: Jara Caytuiro Fabiola , Luyo Kuong Jaime
Published: August 2021

En los últimos años a nivel internacional se están llevando a cabo la interconexión de mercados eléctricos, la cual posibilita la optimización del uso de recursos energéticos y mejora la confiabilidad de los sistemas. Este proceso de integración eléctrica genera una redistribución de los beneficios entre los agentes, lo cual también genera nuevos problemas para la coordinación y regulación, por lo cual existe la necesidad de diseñar nuevas políticas de regulación basadas en análisis de los impactos de la interconexión de mercados transfronterizos. El objetivo del presente artículo es mejorar la comprensión de los efectos que tendrá la interconexión en parámetros como: la evolución del parque de generación electricidad en cada sistema eléctrico, la incorporación de centrales hidroeléctricas de gran tamaño especialmente en países que cuenten con complementariedad hídrica y la incorporación de centrales eléctricas a base de recursos energéticos renovables no convencionales. Para ello, se ha estructurado un modelo que hace uso de la teoría de dinámica de sistemas y se analizó el caso de la interconexión Perú – Ecuador, encontrando que las políticas de estado previamente aplicadas en ambos países han originado que los costo marginales de sus sistemas sean relativamente bajos, con lo cual no ingresaría nueva generación en el corto plazo; asimismo, se concluyó que aunque expandir la capacidad hidroeléctrica puede parecer la mejor solución dada la complementariedad hídrica entre ambos países, los bajos costos marginales hacen que las primeras centrales a ser instaladas sean a base de gas natural.
Analisis Implementasi Kebijakan Pengurangan Risiko Bencana dalam Perspektif Sistem-Ekologi Sosial
Authors: Sagala Dini Asshaliyah , Wike Wike , Danar Oscar Radyan
Published: August 2021

This research aims to reveal the implementation of Disaster risk reduction (DRR) policy in Jayapura city, Papua Province, Indonesia through the socio-ecological system (SES) perspective. It applies descriptive method and uses qualitative approach, which was intended to explore the information correlated to DRR policy directly from its implementing agency. The result of this study shows that implementation of DRR policy in Jayapura city still need to be developed, although it has positive progress in recent years. In social dimension, it has fulfilled the criteria described in SES concept, however, the result is slightly different in ecological aspect. In ecological aspect, some of implementing agencies still lack of technocratic expert to solve technical problem which ecological aspect. Under this circumstance, the structural coordination among implementing agency is difficult to be performed. Thus, the local major of Jayapura still need to establish an emergency’s organization due to critical situation.
Implementasi Kebijakan Hutan Pendidikan (Studi pada Dusun Sumbersari, Desa Tawangargo, Malang)
Authors: Fiulaizi Anna , Sujarwoto Sujarwoto , Sentanu I Gede Eko Putra Sri
Published: August 2021

This paper aims to explain and analyze the implementation of educational forest policy with the implementation model as administrative and political process from Grindle (1980), study on the UB Forest employee forest. The results of this study indicate that the implementation of education forest policy in UB forest is still difficult and be potential for failure. The failure is due to the achievement of the objectives of UB Forest, the program of activities which have not been carried out according to the programs design, and have not yet impacted to social group. This is influenced by various aspects of both the contents of the policy, which includes a) the interests affected; b) type of benefits; c) extend of change envision; d) site of decision making; e) program implementor, and f) resources committed, and the contect of implementation, which includes three (3) aspects; a) power, interests and strategies of the actors involved; b) institutionand regime characteristic; c) compliance and responsiveness.
Pengaruh Remunerasi dan Motivasi terhadap Kinerja Tenaga Administrasi PNS dan Non PNS Universitas Brawijaya
Authors: Geonardo Derian Surya Setiawan , Haryono Bambang Santoso , Hanafi Imam
Published: August 2021

Remuneration policy is born in order not to occur the overlap of income between education, where previously the education of civil servants more income and have more activities than with permanent education Non PNS. This research aims to analyse partial remuneration influence and partial motivation, then the simultaneous influence of remuneration and motivation to the performance of civil servants and non-civil servants at the Faculty of Computer Science of Brawijaya University. This research uses quantitative methods with the method of data collection in the form of a questionnaire. Method of data analysis using SPSS Vr. 24 program. Based on the results of the research came the conclusion that the results of the hypothesis test Fcountdown > Ftabel is 22,976 > 3,204 significance F of < Alpha (0,000 < 0,05) remuneration significantly affects the performance of employees, while motivation also significantly affects the performance of employees.
Comparing The Economy-wide Impact of Omnibus Law: An Input-Output Analysis
Authors: Haryanto Ari Tri , Resosudarmo Budy P.
Published: August 2021

As the Indonesian government issued Omnibus Law to increase investment inflow to Indonesia, this paper tries to figure out investment in what sector that can generate the highest outcome in terms of the macro, micro, and environmental impacts, such that the Indonesian government should prioritize this sector as the investment targeted sector. Three sectors are considered: manufacturing, mining and quarrying, and electricity and gas. Using an I-O model and a microsimulation model, this paper examines the macro, micro, and environmental impacts of each investment scenario. The results reveal that in the short-run, investment in the electricity and gas sector generates the highest macro impacts, while investment in the mining and quarrying sector is better in reducing poverty and inequality, although it has a bigger environmental impact.
The Role of the Canadian Media During the Initial Response to the COVID-19 Pandemic: A Topic Modelling Approach Using Canadian Broadcasting Corporation News Articles
Authors: Patel Janhavi , Desai Harsheev , Okhowat Ali
Published: August 2021

Background

Beginning as a local epidemic, COVID-19 has since rapidly evolved into a pandemic. As countries around the world battle this outbreak, mass media has played an active role in disseminating public health information.

Objective

The aim of this study was to get a better understanding of the role that the Canadian media played during the pandemic and to investigate the patterns of topics covered by media news reporting.

Methods

We used a data set consisting of news articles published on the Canadian Broadcasting Corporation (CBC) website between December 2019 and May 2020. We then used Python software to analyze the data using Latent Dirichlet Allocation topic modelling. Subsequently, we used the pyLDAvis tool to plot these topics on a 2D plane through multidimensional scaling and divided these topics into different themes.

Results

After removing articles that were published before the year 2019, we identified 6771 relevant news articles. According to the CV coherence value, we divided these articles into 15 topics, which were categorized into 6 themes. The three most popular themes were case reporting and testing (n=1738), Canadian response to the pandemic (n=1259), and changes to social life (n=1171), which accounted for 25.67%, 18.59%, and 17.29% of the total articles, respectively.

Conclusions

Understanding the Canadian media’s reporting on the COVID-19 pandemic shows that the Canadian pandemic response is a product of consistent government communication, as well as the public’s understanding of and adherence to protocols.
Morocco's National Response to the COVID-19 Pandemic: Public Health Challenges and Lessons Learned
Authors: Barkia Abdelaziz , Laamrani Hammou , Belalia Abdelmounaim , Benmamoun Abderrahman , Khader Yousef
Published: August 2021

This report aimed to provide an overview of the epidemiological situation of COVID-19 in Morocco and to review the actions carried out as part of the national response to this pandemic. The methodology adopted was based on literature review, interviews with officials and actors in the field, and remote discussion workshops with a multidisciplinary and multisectoral working group. Morocco took advantage of the capacities already strengthened within the framework of the application of the provisions of the International Health Regulations (IHR) of 2005. A SWOT analysis made it possible to note that an unprecedented political commitment enabled all the necessary means to face the pandemic and carry out all the response activities, including a campaign of relentless communication. Nevertheless, and despite the efforts made, the shortage of human resources, especially those qualified in intensive care and resuscitation, has been the main drawback to be addressed. The main lesson learned is a need to further strengthen national capacities to prepare for and respond to possible public health emergencies and to embark on a process overhaul of the health system, including research into innovative tools to ensure the continuity of the various disease prevention and control activities. In addition, response to a health crisis is not only the responsibility of the health sector but also intersectoral collaboration is needed to guarantee an optimal coordinated fight. Community-oriented approaches in public health have to be strengthened through more participation and involvement of nongovernmental organizations (NGOs) and civil society in operational and strategic planning.
Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes
Authors: Kim Sun H. , Brodsky Irwin G. , Chatterjee Ranee , Kashyap Sangeeta R. , Knowler William C. , Liao Emilia , Nelson Jason , Pratley Richard , Rasouli Neda , Vickery Ellen M. , Sarnak Mark , Pittas Anastassios G. ,   D2d Research Group
Published: August 2021

Background and objectives

Low serum 25-hydroxyvitamin D (25[OH]D) concentration has been associated with higher levels of proteinuria and lower levels of eGFR in observational studies. In the Vitamin D and Type 2 Diabetes (D2d) study, we investigated the effect of vitamin D supplementation on kidney outcomes in a population with prediabetes.

Design, setting, participants, & measurements

Overweight/obese adults with high risk for type 2 diabetes (defined by meeting two of three glycemic criteria for prediabetes) were randomized to vitamin D3 4000 IU per day versus placebo. Median duration of treatment was 2.9 years (interquartile range 2.0–3.5 years). Kidney outcomes included (1) worsening in Kidney Disease: Improving Global Outcomes (KDIGO ) risk score (low, moderate, high, very high) on two consecutive follow-up visits after the baseline visit and (2) mean changes in eGFR and urine albumin-to-creatinine ratio (UACR).

Results

Among 2166 participants (mean age 60 years, body mass index 32 kg/m2, serum 25(OH)D 28 ng/ml, eGFR 87 ml/min per 1.73 m2, UACR 11 mg/g, 79% with hypertension), 10% had moderate, high, or very high KDIGO risk score. Over a median follow-up of 2.9 years, there were 28 cases of KDIGO worsening in the vitamin D group and 30 in the placebo group (hazard ratio, 0.89; 95% confidence interval [95% CI], 0.52 to 1.52]). Mean difference in eGFR from baseline was −1.0 ml/min per 1.73 m2 (95% CI, −1.3 to −0.7) in the vitamin D group and −0.1 ml/min per 1.73 m2 (95% CI, −0.4 to 0.2) in the placebo group; between-group difference was −1.0 ml/min per 1.73 m2 (95% CI, −1.4 to −0.6). Mean difference in UACR was 2.7 mg/g (95% CI, 1.2 to 4.3) in the vitamin D group and 2.0 (95% CI, 0.5 to 3.6) in the placebo group; between-group difference was 0.7 mg/g (95% CI, −1.5 to 2.9).

Conclusions

Among persons with prediabetes, who were not preselected on the basis of serum 25(OH)D concentration, vitamin D supplementation did not affect progression of KDIGO risk scores and did not have a meaningful effect on change in UACR or eGFR.
GUÍAS ESQUEMATIZADAS DE TRATAMIENTO DE LOS TRASTORNOS DE LA PERSONALIDAD PARA PROFESIONALES, DESDE EL MODELO DE THEODORE MILLON
Authors: López Pell Andrés Fernando , Rondón Juan Manuel , Cellerino Cecilia , Alfano Silvina María
Published: August 2021

Los tratamientos psicológicos para los Trastornos de la personalidad todavía no alcanzan un grado de protocolización tan específico como para describir las intervenciones para cada sesión. Esto podría deberse a la heterogeneidad de los casos que dificultaría la posibilidad de diseñar un protocolo. Los tratamientos entonces se basan en conceptualizaciones de caso sustentadas teóricamente que después determinan los objetivos y las intervenciones a realizar. La dificultad para conceptualizar desde determi-nado modelo puede que sea una razón por la que a los psicoterapeutas les costaría realizar el tratamiento más adecuado. Para afrontar este problema hemos diseñado unas ‘Guías esquematizadas para profesio-nales’ para mejorar la práctica de la psicoterapia para los trastornos y alteraciones de la personalidad. Estas guías son de una carilla para tenerlas a la vista durante las sesiones a fin conceptualizar los casos y guiar más fácilmente las intervenciones desde el modelo de Theodore Millon.
CALIDAD DE VIDA RELACIONADA CON LA SALUD EN MUJERES URUGUAYAS CON CÁNCER DE MAMA
Authors: Bajuk Laura , Reich Micaela
Published: August 2021

Existen diversas investigaciones científicas que estudian la relación entre Cáncer de Mama y Calidad de Vida. Sin embargo, la investigación en Uruguay es aún incipiente. Este estudio tiene como objetivo principal la caracterización de una muestra de mujeres uruguayas con Cáncer de Mama recibiendo atención médica post-quirúrgica en el Instituto Nacional de Cáncer. La muestra analizada (n=34 mujeres) completó un formulario de Datos Sociodemográficos y Clínicos diseñado ad hoc para este estudio y el Cuestionario de Salud MOS-SF-36 V. 2.0. La media de edad de las participantes fue de 56,06 años. La mayoría de las participantes recibió Quimioterapia (73,5%), Radioterapia (64,7%) o la combinación de ambos (58,8%). El tipo de cirugía más frecuente fuela Mastectomía RadicalModificada (53%). Se hallaron correlaciones estadísticamente significativas entre variables clínicas, sociodemográficas y el SF-36. Se concluyó que el tipo de cirugía así como el tratamiento recibido tienen una importante incidencia enla Calidadde Vida Relacionada conla Saludde estas mujeres.
DIFICULTADES EN LA IMPLEMENTACIÓN DE MODELOS DE GESTIÓN DE RECURSOS HUMANOS: UNA APROXIMACIÓN A LA REALIDAD URUGUAYA
Authors: Neira Fernando
Published: August 2021

En este artículo presentamos los resultados preliminares de una investigación en curso, sobre las dificultades existentes en Uruguay para la implementación de Modelos de Gestión de RR.HH. en las empresas. Se realizó  un trabajo de campo sobre los Modelos de gestión aplicados en un sector de actividad y su impacto sobre la estrategia del negocio, llegando a tres hipótesis de trabajo cuyo análisis preliminar es motivo de esta comunicación: Una referida a la  filosofía empresarial predominante enla Alta Direcciónde las empresas uruguayas que impide visualizar, que una adecuada gestión del Capital Humano constituye un elemento clave para el logro dela Estrategiade Negocio. Una segunda hipótesis que se centra en quela Gestiónde RR.HH. no se realiza mediante la utilización Modelos de Gestión sino, a través de una variada serie de herramientas que no necesariamente forman parte de un Sistema o Modelo mayor.Una última hipótesis que refiere a como las Relaciones Laborales condicionan la implementación de sistemas o modelos de gestión integral del Capital Humano.
A moral dilemma: The use of zinc in patients hospitalized with COVID pneumonia
Authors: Manigault Ebony M , Donohue Laura , Moore Elizabeth , Abuaita Yara
Published: August 2021

A clinical decision report using:

Yao JS, Paguio JA, Dee EC, Tan HC, Moulick A, Milazzo C, Jurado J, Della Penna N, Celi LA. The minimal effect of zinc on the survival of hospitalized patients with COVID-19: an observational study. Chest. 2021 Jan;159(1):108-111. https://doi.org/10.1016/j.chest.2020.06.082

for a patient hospitalized with COVID pneumonia requiring high flow oxygen.
Penerapan kualitas pelayanan pramusaji pada pesisi restoran di the alantara sanur
Authors: Tunjungsari Komang Ratih , Swari Putu Ayu Indra
Published: August 2021

Penelitian ini dilakukan di The Alantara Sanur yang beralamat di Jalan Tirta Ening No. 12, Sanur Kauh, Denpasar, Bali. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan kualitas pelayanan pramusaji pada Pesisi Restoran di The Alantara Sanur. Teknik sampling yang digunakan adalah Quota Sampling, dengan sampel yang digunakan yaitu 1 manajer restoran, 2 pramusaji, dan 20 tamu Pesisi Restoran. Teknik pengumpulan data yang digunakan berupa kuesioner, wawancara, observasi, dan juga dokumentasi. Teknik analisis data yang digunakan yaitu deskriptif kuantitatif. Dari hasil penelitian diketahui bahwa penerapan kualitas pelayanan yang dilakukan oleh pramusaji Pesisi Restoran dinilai sangat baik oleh tamu berdasarkan kuesioner dengan nilai 4,44 yang dikategorikan sangat baik dan data tersebut didukung oleh hasil wawancara, observasi, dan juga guest comment.
Reacquisitions vs. “regular” acquisitions and divestitures: A comparison of investor responses
Authors: Dietz Benjamin , zu Knyphausen-Aufseß Dodo
Published: August 2021

Studies on mergers and acquisitions (M&A), as well as on divestitures, suffer from heterogeneity within their research universe. This study sheds light on one specific type of transaction that, despite its relevance, has remained understudied: reacquisitions. Reacquisitions are a type of M&A in which previously divested company parts are reacquired by parent companies. Drawing on recent research on how investors assess M&A (e.g., Harrison & Schijven, 2016; Schijven & Hitt, 2012), as well as on the occurrence of reacquisitions (e.g., Gleason, Madura, & Pennathur, 2006), we focus on three empirical questions and show that most reacquisitions are likely to be associated with negative signals about potential synergy, as well as with information about problems or threats related to the reacquiring companies. Based on an event study of 71 reacquisitions and 71 divestitures followed by reacquisitions, and comparing them against “regular” M&A and divestitures, we find, inter alia, that investors assess reacquisitions significantly more negatively than regular M&A. Our findings support the view that investors’ assessments are based on incomplete information and do not necessarily reflect actual performance
Perimedullary Spinal Arteriovenous Malformation in an Elderly Female: A Case Report
Authors: Basnet Madan , Gaire Suman , Phudong Abisha , Gautam Kamal , Subedhi Prarthana , Chamlagain Rajan , SHAH SANGAM
Published: August 2021

Perimedullary spinal AVM is a rare type of spinal arteriovenous
malformations. We present a case of 70 yrs female who presented with
motor weakness in her bilateral limbs. Initial MRI was misinterpreted as
ependymal myxoma; however, histopathology revealed spinal AVM. MRA or
DSA should be conducted if AVM is suspected.
Glucose-Lowering Therapy in Patients With Postpancreatitis Diabetes Mellitus: A Nationwide Population-Based Cohort Study
Authors: Viggers Rikke , Jensen Morten Hasselstrøm , Laursen Henrik Vitus Bering , Drewes Asbjørn Mohr , Vestergaard Peter , Olesen Søren Schou
Published: August 2021

OBJECTIVE

Postpancreatitis diabetes mellitus (PPDM) is a type of secondary diabetes that requires special considerations for management. The main objective was to examine prescription patterns of glucose-lowering therapy among adults with PPDM compared with type 1 and type 2 diabetes.

RESEARCH DESIGN AND METHODS

In a Danish nationwide population-based cohort study, we identified all individuals with adult-onset diabetes in the period 2000–2018 and categorized them as having type 1 diabetes, type 2 diabetes, or PPDM. We ascertained diabetes incidence rates, clinical and demographic characteristics, and classifications and prescription patterns of glucose-lowering therapy and compared these parameters across diabetes subgroups.

RESULTS

Among 398,456 adults with new-onset diabetes, 5,879 (1.5%) had PPDM, 9,252 (2.3%) type 1 diabetes, and the remaining type 2 diabetes (96.2%). The incidence rate of PPDM was 7.9 (95% CI 7.7–8.1) per 100,000 person-years versus 12.5 (95% CI 12.2–12.7) for type 1 diabetes (incidence rate ratio 0.6 [95% CI 0.6–0.7]; P < 0.001). A sizeable proportion of patients with PPDM were classified as having type 2 diabetes (44.9%) and prescribed sulfonylureas (25.2%) and incretin-based therapies (18.0%) that can potentially be harmful in PPDM. In contrast, 35.0% of patients never received biguanides, which are associated with a survival benefit in PPDM. Increased insulin requirements were observed for patients with PPDM compared with type 2 diabetes (hazard ratio 3.10 [95% CI 2.96–3.23]; P < 0.001) in particular for PPDM associated with chronic pancreatitis (hazard ratio 4.30 [95% CI 4.01–4.56]; P < 0.001).

CONCLUSIONS

PPDM is a common type of secondary diabetes in adults but is often misclassified and treated as type 2 diabetes, although PPDM requires special considerations for management.
New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms
Authors: Bizzotto Roberto , Tricò Domenico , Natali Andrea , Gastaldelli Amalia , Muscelli Elza , De Fronzo Ralph A. , Arslanian Silva , Ferrannini Ele , Mari Andrea
Published: August 2021

OBJECTIVE

Endogenous insulin clearance (EIC) is physiologically reduced at increasing insulin secretion rate (ISR). Computing EIC at the prevailing ISR does not distinguish the effects of hypersecretion from those of other mechanisms of glucose homeostasis. We aimed to measure EIC in standardized ISR conditions (i.e., at fixed ISR levels) and to analyze its associations with relevant physiologic factors.

RESEARCH DESIGN AND METHODS

We estimated standardized EIC (EICISR) by mathematical modeling in nine different studies with insulin and glucose infusions (N = 2,067). EICISR association with various traits was analyzed by stepwise multivariable regression in studies with both euglycemic clamp and oral glucose tolerance test (OGTT) (N = 1,410). We also tested whether oral glucose ingestion, as opposed to intravenous infusion, has an independent effect on EIC (N = 1,555).

RESULTS

Insulin sensitivity (as M/I from the euglycemic clamp) is the strongest determinant of EICISR, approximately four times more influential than insulin resistance–related hypersecretion. EICISR independently associates positively with M/I, fasting and mean OGTT glucose or type 2 diabetes, and β-cell glucose sensitivity and negatively with African American or Hispanic race, female sex, and female age. With oral glucose ingestion, an ISR-independent ∼10% EIC reduction is necessary to explain the observed insulin concentration profiles.

CONCLUSIONS

Based on EICISR, we posit the existence of two adaptive processes involving insulin clearance: the first reduces EICISR with insulin resistance (not with higher BMI per se) and is more relevant than the concomitant hypersecretion; the second reduces EICISR with β-cell dysfunction. These processes are dysregulated in type 2 diabetes. Finally, oral glucose ingestion per se reduces insulin clearance.
Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial
Authors: Lee Melissa H. , Paldus Barbora , Vogrin Sara , Morrison Dale , Zaharieva Dessi P. , Lu Jean , Jones Hannah M. , Netzer Emma , Robinson Lesley , Grosman Benyamin , Roy Anirban , Kurtz Natalie , Ward Glenn M. , MacIsaac Richard J. , Jenkins Alicia J. , O’Neal David N.
Published: August 2021

OBJECTIVE

To evaluate glucose control using fast-acting insulin aspart (faster aspart) compared with insulin aspart (IAsp) delivered by the MiniMed Advanced Hybrid Closed-Loop (AHCL) system in adults with type 1 diabetes.

RESEARCH DESIGN AND METHODS

In this randomized, open-label, crossover study, participants were assigned to receive faster aspart or IAsp in random order. Stages 1 and 2 comprised of 6 weeks in closed loop, preceded by 2 weeks in open loop. This was followed by stage 3, whereby participants changed directly back to the insulin formulation used in stage 1 for 1 week in closed loop. Participants chose their own meals except for two standardized meal tests, a missed meal bolus and late meal bolus. The primary outcome was the percentage of time sensor glucose values were from 70 to 180 mg/dL (time in range [TIR]).

RESULTS

Twenty-five adults (52% male) were recruited; the median (interquartile range) age was 48 (37, 57) years, and the median HbA1c was 7.0% (6.6, 7.2) (53 [49, 55] mmol/mol). Faster aspart demonstrated greater overall TIR compared with IAsp (82.3% [78.5, 83.7] vs. 79.6% [77.0, 83.4], respectively; mean difference 1.9% [0.5, 3.3]; P = 0.007). Four-hour postprandial glucose TIR was higher using faster aspart compared with IAsp for all meals combined (73.6% [69.4, 80.2] vs. 72.1% [64.5, 78.5], respectively; median difference 3.5% [1.0, 7.3]; P = 0.003). There was no ketoacidosis or severe hypoglycemia.

CONCLUSIONS

Faster aspart safely improved glucose control compared with IAsp in a group of adults with well-controlled type 1 diabetes using AHCL. The modest improvement was mainly related to mealtime glycemia. While the primary outcome demonstrated statistical significance, the clinical impact may be small, given an overall difference in TIR of 1.9%.
New Insights on the Interactions Between Insulin Clearance and the Main Glucose Homeostasis Mechanisms
Authors: Bizzotto Roberto , Tricò Domenico , Natali Andrea , Gastaldelli Amalia , Muscelli Elza , Fronzo Ralph A. De , Arslanian Silva , Ferrannini Ele , Mari Andrea
Published: August 2021

Objective
Endogenous insulin clearance (EIC) is physiologically reduced at increasing
insulin secretion rate (ISR). Computing EIC at the prevailing ISR does not
distinguish the effects of hypersecretion from those of other mechanisms of
glucose homeostasis. We aimed to measure EIC in standardized ISR conditions
(i.e., at fixed ISR levels) and to analyze its associations with relevant
physiologic factors.

Research
Design and Methods We estimated standardized EIC (EICISR) by mathematical
modelling in 9 different studies with insulin and glucose infusions (N=2067).
EICISR association with various traits was analyzed by stepwise
multivariable regression, in studies with euglycemic clamp and OGTT (N=1410).
We also tested whether oral glucose ingestion, as opposed to intravenous
infusion, has an independent effect on EIC (N=1555).

Results
Insulin sensitivity (as M/I from the euglycemic clamp) is the strongest
determinant of EICISR, ~4 times more influential than
insulin-resistance related hypersecretion. EICISR independently
associates positively with M/I, fasting and mean OGTT glucose or type 2
diabetes, and β-cell glucose sensitivity, and negatively with African American
or Hispanic race, female sex, and female age. With oral glucose ingestion, an
ISR-independent ~10% EIC reduction is necessary to explain the observed insulin
concentration profiles.

Conclusions
Based on EICISR, we posit the existence of two adaptive processes
involving insulin clearance: the first reduces EICISR with insulin
resistance (not with higher BMI per se)
and is more relevant than the concomitant hypersecretion; the second reduces
EICISR with β-cell dysfunction. These processes are dysregulated in
type 2 diabetes. Finally, oral glucose ingestion per se reduces insulin clearance.
Fast-Acting Insulin Aspart Versus Insulin Aspart Using a Second-Generation Hybrid Closed-Loop System in Adults With Type 1 Diabetes: A Randomized, Open-Label, Crossover Trial
Authors: Lee Melissa H. , Paldus Barbora , Vogrin Sara , Morrison Dale , Zaharieva Dessi P. , Lu Jean , Jones Hannah M. , Netzer Emma , Robinson Lesley , Grosman Benyamin , Roy Anirban , Kurtz Natalie , Ward Glenn M. , MacIsaac Richard J. , Jenkins Alicia J. , O’Neal David N.
Published: August 2021

Objective

To evaluate glucose control
using fast-acting insulin aspart (faster aspart) compared with insulin aspart
(IAsp) delivered by the MiniMedä Advanced Hybrid Closed-Loop
(AHCL) system in adults with type 1 diabetes.

Research Design and Methods

In this randomized,
open-label, crossover study, participants were assigned to receive faster aspart or IAsp in random-order. Stages
1 and 2 comprised six-weeks in closed-loop; preceded by two-weeks in open-loop.
This was followed by Stage 3, whereby participants changed directly back to the
insulin formulation used in Stage 1 for one-week in CL. Participants
chose their own meals except for two standardized meal tests; a missed and late
meal bolus. Primary outcome was % sensor glucose time-in-range (TIR; 70-180mg/dL).

Results

Twenty-five adults (52% male)
were recruited; median (IQR) age was 48 (37, 57) years, and HbA1c 7.0%
(6.6, 7.2) (53 [49, 55] mmol/mol). Faster aspart demonstrated greater overall
TIR compared with IAsp (82.3% [78.5, 83.7] vs. 79.6% [77.0, 83.4],
respectively; mean difference 1.9% [0.5, 3.3]; p=0.007). Four-hour PPG
TIR was higher using faster aspart compared with IAsp for all-meals combined (73.6% [69.4, 80.2] vs. 72.1% [64.5, 78.5],
respectively; median difference 3.5% [1.0, 7.3]; p=0.003). There was no
ketoacidosis or severe hypoglycemia.

Conclusions

Faster aspart safely improved
glucose control compared with IAsp in a well-controlled group of adults with
type 1 diabetes using AHCL. The modest improvement mainly related to mealtime glycemia.
Whilst the primary outcome demonstrated statistical significance, the clinical
impact may be small given an overall difference in TIR of 1.9%.
Alexander Olegovich Glyco-70 years
Authors: Селиверстова Г.П.
Published: August 2021

Исполнилось 70 лет Александру Олеговичу Глико
– известному российскому ученому-геофизику, акаде-
мику РАН.

70th anniversary of Alexander O. Gliko
 well – known Russian scientist-Geophysics
Optimal Recovery of the Operators of the Divided Difference of the Inaccurately Given Sequence by the Fourier Transform
Authors: Унучек С.А.
Published: August 2021

В различных прикладных задачах часто нужно восстановить
какую-либо характеристику объекта по некоторой информации (как
правило, неполной или неточной) о других его характеристиках.
Существуют различные подходы к решению аналогичных задач. В данной
работе использовался подход, основанный на идеях Андрея Николаевича
Колмогорова (в работах о $n$-поперечниках) о наилучших средствах
приближения конечномерными подпространствами. Суть метода
заключается в том, что ищется наилучшее средство аппроксимации на
целом классе. Рассматривается задача одновременного восстановления
операторов разделенных разностей всех порядков от $1$ до $(n-1)$-го
включительно на классе последовательностей с ограниченной
$n$-ой разделенной разностью. При этом преобразование Фурье
данной последовательности известно приближенно на некотором отрезке
в среднеквадратичной норме. Построено семейство оптимальных методов
восстановления. Среди найденных методов есть те, которые используют
минимальную информацию о последовательности, предварительно
"сглаживая" ее. Найдено точное значение оптимальной погрешности
восстановления операторов разделенных разностей. Предельным
переходом из полученных результатов вытекает непрерывный
случай.
Теорема Гордона: истоки и смысл
Authors: Kusraev A.G. , Kutateladze S.S.
Published: August 2021

Boolean valued analysis, the term coined by Takeuti, signifies a branch of functional analysis which uses a special technique of Boolean valued models of set theory. The fundamental result of Boolean valued analysis is Gordons Theorem stating that each internal field of reals of a Boolean valued model descends into a universally complete vector lattice. Thus, a remarkable opportunity opens up to expand and enrich the mathematical knowledge by translating information about the reals to the language of other branches of functional analysis. This is a brief overview of the mathematical events around the Gordon Theorem. The relationship between the Kantorovichs heuristic principle and Boolean valued transfer principle is also discussed.
MICROSOFT TEAMS AS A TOOL FOR FOREIGN LANGUAGE STUDY AT UNIVERSITY
Authors: Морквина Елена Александровна , Логинова Елена Александровна
Published: August 2021

Рассматривается понятие и принципы дистанционного обучения. Определяется значение интернет-технологий для изучения иностранного языка. Характеризуются функциональные возможности онлайн-платформы Microsoft Teams. На основе анкетных данных анализируется опыт дистанционного обучения в Тюменском государственном университете в рамках дисциплины «Иностранный язык» на базе MS Teams. Проводится соотношение между инструментами MS Teams и параметрами занятия по иностранному языку. Определяются значимые для изучения иностранного языка функции платформы, а также возникающие трудности.

This paper presents the concept, principles of distance education and its relationship with the terms online-learning and e-learning. The author determines the importance of Internet technologies for foreign language learning and the formation of foreign language communicative (often professionally oriented) competence as the main task of this subject. The article gives the reflections of the functionality of the Microsoft Teams online platform to create a unique online learning environment. The issue is addressed by analyzing the survey data on learning foreign languages online via the MS Teams at the University of Tyumen. The specific objective of the study is to juxtapose the MS Teams tools with the parameters of organizing classes in foreign languages such as interactivity, multimedia, the implementation of the learner-centered approach, the teaching and learning materials used, teaching methods and forms, the creation of an authentic environment and the formation of various types of speech activity. In addition, the study defines the most significant MS Teams functions, in particular, storing educational materials, having feedback, video communication (online-meetings), working in teams and channels, MS Teams tests, working with co-editing files etc. The author identifies the difficulties that arise (namely technical, psychological, physiological, methodological difficulties and problems in perceiving information), their possible causes and ways to overcome them. The article ends with conclusions on how MS Teams integrates into the foreign languages learning process.
Role of multiple reflections in the formationof wave field in the cretaceous successions of the Middli Kura depression in Azerbaijan
Authors: Akhmedov T. R. , Niyazov T. Kh.
Published: August 2021

The article is devoted to the elucidation of the nature of the wave field recorded below the supporting-dominant seismic horizon «P» in the Middle Kura depression of Azerbaijan. A brief overview of the work carried out here is given; it is indicated that some geologists and geophysicists of our country, in our opinion, mistakenly assume that the observed wave field below the specified horizon is formed mainly by multiple reflections.

Since the introduction of the common depth point method into the practice of seismic exploration, individual areas of the Middle Kura depression in Azerbaijan, including the Yevlakh-Agjabedi trough, have been repeatedly studied with varying degrees of frequency tracking. On the basis of this, a fairly large number of promising structures have been identified and mapped. But the structure of the Mesozoic, in particular the deposits of the Upper Cretaceous, still remains insufficiently studied.

The study of the geological structure of the Mesozoic sediments, which are considered promising in terms of oil and gas content, is an urgent geological task; exploration work was carried out in the studied areas of the Middle Kura depression using a complex of geophysical methods at the modern technical and methodological level and new results were obtained. The constructed seismic sections show a dynamically pronounced and well-traceable seismic horizon corresponding to the Mesozoic surface and located deeper than it, relatively weak, short, discontinuous reflective boundaries that characterize the structure within the Mesozoic deposits. The studies carried out on the basis of modeling and velocity analysis made it possible to prove that the wave field in the time interval corresponding to the Mesozoic deposits owes its origin to intermittent single reflections from volcanic-carbonate deposits of the Upper Cretaceous age.