bluuebunny/crossref_metadata_2025 huggingface dataset:
Promosi Kesehatan Hipertensi Di Desa Kutamukti Kecamatan Kutawakuya
Authors: Nina Nina , Novita Astrid
Published: June 2020

Pengabdian dilaksanakan di lingkungan Posyandu  Wilayah  Kerja  Kesehatan Hipertensi Di Desa Kutamukti Kecamatan Kutawakuya. Hasil dari penyuluhan tersebut adalah Pukesmas Kutamukti  Kelurahan  Kutakarya,  Kecamatan  Kutawaluya. Pengabdian ini mengambil Judul Penyuluhan Promosi menunjukkan bahwa masyarakat di Desa Kutamukti Kecamatan Kutawakuya Tingkat pengetahuan masyrakat mengenai hipertensi sebelum kegiatan ialah sebesar 78% dan naik menjadi 98% setelah pelaksanaan kegiatan. Berdasarkan hasil pemeriksaan tekanan darah, 51% (23 orang) mengalami masalah kesehatan tekanan darah tinggi, atau hipertensi. sisanya, sebesar 31% (14 orang) bertekanan darah normal dan 18% lainnya (8 orang) bertekanan darah rendah. Berdasarkan hasil pemeriksaan gula darah sewaktu, 9% (4 orang) mengalami masalah kesehatan gula darah tinggi sedangkan 91% (41 orang) memiliki kondisi gula darah yang normal. Berdasarkan hasil pemeriksaan asam urat 40% (18 orang) mengalami masalah kesehatan asam urat tinggi sedangkan 60% (27 orang) memiliki kondisi gula darah yang normal. Dari evaluasi kegiatan pengabdian masyarakat yang telah dilakukan maka kegiatan ini sangat penting dan bermanfaat dalam meningkatkan pengetahuan masyarakat mengenai kesehatan Hipertensi dan perlu adanya rencana tindak lanjut dari kegiatan ini.
RECREATION OFFER AND COMPETENCES NEEDED FOR ITS DEVELOPMENT IN ACCOMMODATION ENTERPRISES OF KURZEME REGION IN LATVIA
Authors: Līduma Diāna , Grospiņa Ilze , Gusta Zane
Published: June 2020

Due to changes in tourism habits when planning development of tourism industry both on national and regional scale, the significance of recreation is highlighted. As a result, in tourism products made by guest accommodation enterprises the recreation offer is included more and more often.
Within the research it has been found out that in guest accommodation enterprises in Kurzeme, in addition to accommodation opportunities, the offer of catering dominates, but regarding recreation activities- walking and relaxation in nature. The offer of bath-house treatment and cycling are more popular than SPA procedure and water attractions. The tendency of relaxation and entertainment event organization also increases in the companies. One realized imperfection of the offer is the tendency that in half of the regional accommodation enterprises the arrangement of relaxation activities has to be provided by the clients themselves.
The aim of the research is to find out the offer of the current recreation in guest accommodation enterprises in Kurzeme Region and the necessary employees’ competences for its further development. Within the research a survey of 32 managers of guest accommodation enterprises in Kurzeme Region was carried out. The outcomes of the research reveal that additional services to accommodation are offered by 55% guest accommodation enterprises of Kurzeme. However, in 53.1% cases the clients, staying at a guest accommodation enterprise in Kurzeme Region, have to provide arrangement of relaxation activities themselves. Only one fifth (21.9%) of the companies provide it involving a specialist working for the company. Complex recreation programmes are offered by 9.7%, but separate recreation activities by 29% guest accommodation enterprises. Managers of guest accommodation enterprises in Kurzeme are aware of the potential in sports recreation events and relaxation activity organization. The outcomes of the research showed that the main competences necessary for the employees of guest accommodation enterprises, according to the managers of the companies, are language skills and the ability to make decisions and solve problem-situations. In 15.6% of the enterprises a manager for relaxation arrangements would be needed right now.
Keywords: recreation offer, recreation activities, guest accommodation, specialists of recreation, competences, survey.
Prison Commitment in the Implementation of the Scabies Management Program in Class II A Prison Rantauprapat
Authors: Ida Rizkia  , Zulfendri  , Taufik Ashar
Published: June 2020

Scabies is a contagious skin infection caused by infestation and sensitivity to Sarcoptes scabiei varietahominis which is included in the Arachnida class. Data obtained from the Class II-A Prison clinic that the disease that is often experienced by prisoners is a skin disease such as scabies. The policy for scabies prevention and prevention in Class II-A Prison Rantauprapat has been pursued in 2017, but these efforts have not yet yielded encouraging results, because the number of scabies sufferers continues to increase each month. The purpose of this study is to see the commitment of prisons in the implementation of scabies program in Class II-A Prison in Rantauparapat. This qualitative research method uses case studies with in-depth interviews and includes various sources of information. There were five informants in this study, namely 1 Head of Class II-A Prison Rantauprapat, 1 prison Doctor, 1 prison Nurse, 2 prison. The results showed that the commitment of the prison party was quite low so that the implementation of the scabies program in Class II-A Prison Rantau Parapat was not going well.
Dry matter production and radiation use efficiency of pulses grown under different light conditions
Authors: Manoj KN , Umesh MR , Ramesh YM , Anand SR , Angadi Sangu
Published: June 2020

A field experiment was conducted to determine the effects of varying light conditions on growth, morphology and seed yield of pulses. Treatments consisted of 50, 75 and 100% of the full sunlight tested in pigeonpea, cowpea, lablab and blackgram species. Under field condition, artificial shade was created by erecting white nylon nets at 30 days and maintained until final harvest. Results showed that shading at both 50 and 75% of the full sunlight had significant (p < 0.05) negative effect on leaf area index (16 - 35%), total dry matter production (11 - 18%), grain yield (19 - 32%) of pulses over full sunlight. However, radiation use efficiency (RUE) of pulses based on either grain or biomass production was higher in shade plants. Pigeonpea and lablab were relatively shade tolerant compared to cowpea and blackgram with potential crops for growth under reduced light environment conditions.
Morphological and anatomical investigation of three Scandix species from Turkey
Authors: Demirpolat Azize , Dogan Gulden , Bagci Eyup
Published: June 2020

Morphological, morphometrical and anatomical features of some Scandix species (Scandix pectenveneris, S. macrorhyncha and S. balansae) were investigated to compare and determine the taxonomic importance of these characters. Description, synonyms, Turkish names, flowering times, habitat properties and anatomical structure of each species were determined. According to morphological and anatomical characters S. macrorhyncha and S. pecten-veneris showed high-level similarity. However, endemic S. balansae showed distinct both morphological and anatomical differences from the other Scandix species.
Helicobacter pylori CagA seropositivity in adult Bangladeshi patients with peptic ulcer and erosion
Authors: Rahman Fahmida , Shadia Khandaker , Khatun Salma , Mahmud Mafruha , Dutta Indrajit Kumar , Haq Jalaluddin Ashraful
Published: June 2020

Background: CagA IgG antibody in sera might indicate presence of virulent Helicobacter pylori in patients with peptic ulcer disease. Present study was performed to find out the prevalence of CagA IgG antibody in patients with peptic ulcer/erosion.

Methods: Any case that had peptic ulcer/erosion, plus positive for rapid urease test (RUT) or H. pylori stool antigen (HpSAg) or serum anti-H. pylori IgG/IgA were included in the study and named as H. pylori positive case. H. pylori positive cases were tested for CagA IgG antibody. Anti-H. pylori IgG, IgA and CagA IgG antibodies were determined by enzyme-linked immunosorbent assay (ELISA) and stool antigen by rapid immunochromatographic test (ICT). Urease production in biopsy sample was detected by RUT.

Results: Total 86 H. pylori positive patients were included in the study. Out of 86 patients, CagA IgG was positive in 34 (39.5%; 95% CI: 0.30,0.50) cases. CagA seropositivity rate in ulcer and erosion cases were 58.8% (95% CI: 0.36,0.78) and 34.8% (95% CI: 0.25,0.47) respectively. H. pylori stool antigen and IgA antibodies were positive in all (100%) CagA antibody positive ulcer cases while the rates were significantly less among the CagA antibody negative cases (42.8% and 28.6%; p<0.05). However, in CagA antibody positive erosion cases, the rates were not significantly different from CagA antibody negative cases.

Conclusion: The study has demonstrated that the CagA positive strain is less prevalent in erosion than ulcer cases.

Ibrahim Med. Coll. J. 2020; 14(1): 36-40
Tuberculosis – burden and serodiagnosis
Authors: Md Mohiuddin -
Published: June 2020

Tuberculosis (TB) is one of the leading causes of death worldwide. Clinical features and demonstration of the organism by microscopy/culture are still the mainstay of diagnosis of tuberculosis. The present paper reviews the burden of TB and the role of serology in its diagnosis.

Ibrahim Med. Coll. J. 2020; 14(1): 59-69
Kalastusmatkailuelämyksen asiakasarvo
Authors: Turunen Lari , Komppula Raija , Suni Jarno
Published: June 2020

Tutkimuksen tarkoituksena on lisätä ymmärrystä siitä, miten kalastusmatkailuelämyksen arvo muodostuu ja millaisia sisältöjä arvon eri ulottuvuudet edustavat. Tavoitteena on myös tunnistaa erilaisia kalastusmatkailijatyyppejä sen perusteella, mitkä arvokomponentit koetaan tärkeimmiksi kalastusmatkailuelämyksen muodostumisessa. Tutkimuksen kohteena ovat suomalaiset vakavasti harrastukseensa suhtautuvat kalastuksen harrastajat, jotka tekevät säännöllisesti kalastusmatkoja sekä kotimaassa että ulkomailla. Aineistonkeruumenetelmänä käytettiin narratiivista haastattelua, jossa haastateltavia rohkaistiin kertomaan esimerkkejä ikimuistoisista kalastusmatkoistaan. Haastateltavat valittiin lumipallo-otannalla. Kolmentoista haastattelun aineisto analysoitiin teoriaohjaavalla sisällönanalyysilla Shethin, Newmanin ja Grossin (1991) kulutusarvoteorian viitekehyksessä, täydennettynä Komppulan ja Gartnerin (2013) esittämällä yhteisöllisyyden arvolla. Tulosten mukaan kalastuselämyksen muodostuminen oli vahvasti kytköksissä neljään tekijään: 1) kalastamiseen ja saaliin saamiseen (funktionaalinen arvo), 2) luontoon ja luonnonläheisyyteen (emotionaalinen arvo), 3) ystävien ja/tai oman perheen kanssa vietettyyn aikaan (yhteisöllinen arvo) sekä 4) henkiseen hyvinvointiin (emotionaalinen arvo). Yhteisöllisyyden arvo, emotionaalinen arvo ja elämyksen dimensioihin liittyvät aistihavainnot olivat kaikilla haastatelluilla tärkeitä elämysarvoa tuottavia asioita. Yhdessä oleminen ja tekeminen oli sidoksissa henkiseen hyvinvointiin. Kaveriporukassa kalastavat olikin aineistossa yleisin kalastusmatkailijatyyppi. Toiseksi eniten haastatelluissa oli luonnosta nauttijoita, jotka arvostavat luontoa ja kohteen autenttisuutta. Uutuusarvoa arvostavilla tutkimusmatkailijoilla kalastuselämyksen ydin rakentuu tuntemattomissa kohteissa saavutettaviin uusiin kokemuksiin. Harvinaisin tyyppi, jota edusti vain yksi henkilö, oli harrastukseen sitoutunut kalastusmatkailija. Hänelle elämyksen ydin on suurten kalojen saaminen. Tutkimuksen johtopäätöksenä esitetään, että Shethin, Newmanin ja Grossin (1991) malli, täydennettynä yhteisöllisyyden kaksiulotteisella (perheyhteisö, kaveriyhteisö) arvolla, soveltuu aiempia matkailuelämyksen viitekehyksiä paremmin harrastuspohjaisen matkailuelämyksen tarkasteluun. Vaikka monissa harrasteissa itse suoritus tapahtuu yksin, kokemusten jakaminen jonkin yhteisön kanssa voi olla tärkeää.
PROFESSIONAL COMPETENCE UNDERSTANDING LEVEL OF ELEMENTARY SCHOOL IN IMPLEMENTING CURRICULUM 2013
Authors: Wachidi Wachidi , Rodgers Adrian , Tumanov Dmitriy Yu
Published: June 2020

The specific purpose of this study is to find out professional competence understanding level of elementary school teacher in implementing curriculum 2013 in Bengkulu city. This study used analytical descriptive. This study aimed at describing the professional competence understanding level of elementary school teacher in implementing curriculum 2013. The subject of this study was 100 teachers of elementary schools in Bengkulu City. The object of this study was related to professional competence understanding level of elementary school teacher in implementing Curriculum 2013. The data collecting was conducted by using questionnaire and document. Questionnaire was used to obtain the data about professional competence understanding level of elementary school teacher in implementing Curriculum 2013. To find out and to proof that questionnaire is valid was conducted by expert. Document was used to find out the number of elementary school teacher in Bengkulu City. After the data was collected it was verified, and was processed by using percentage statistic method. The data processing was then analyzed and concluded. In general this study concluded that elementary school teachers in Bengkulu city understands professional competence in implementing curriculum 2013.
ENGLISH LANGUAGE TEACHING IN POST-GENOCIDE RWANDA: A STUDY OF TEACHERS’ OBSERVANCE OF THE GRICE’S COOPERATIVE PRINCIPLE
Authors: Karasenga Jean de Dieu , Nkundabatware Innocent , Munyansanga Olivier
Published: June 2020

The purpose of this paper is to report about how teachers of English in Rwanda implement Grice’s cooperative principle in their classrooms, the challenges they face while implementing it, and how they deal with those challenges. The study upon which this paper is based used survey questionnaires, observations, and interviews as methods of data collection. Grounded theory analysis was employed to make sense of the data. Research findings are articulated according to four maxims including quantitative maxim, qualitative maxim, maxim of relevance, and the maxim of manner. They include the fact that teachers struggle with teaching the prescribed curriculum, communicating with students in English, and teaching what is at their students’ learning level. The paper concludes by devising implications of the findings for policy and practice.
POST-STROKE DEPRESSION (MODERN LOOK AT THE PROBLEM AND OWN RESEARCH)
Authors: Onopriyenko O.P.
Published: June 2020

The high incidence and increase in disability among the population after a stroke is a topical problem worldwide in the second decade of the 21st century. Brain strokes, their complications (dementias, depression), place a heavy burden on the society of the country, the families of patients.
Objective: To investigate the impact of psychogenic factors on the epidemiology of stroke in Brоvаry district of Kyiv region for the last 10 years, to compile statistics and to compare them with world and regional data of Kyiv region and Ukraine.
Methods. The resources of PubMed (1990-2016) and UpToDate (2016) were used to write the review article. To address these issues and to improve the quality of care provided to patients in the Kyiv region, Brovary and Brovary district, an epidemiological study of stroke patients and its risk factors has been continued. We screened 771 patients with stroke in the angioneurology department of the Brоvаry Multidisciplinary Clinical Hospital of the Kyiv region for psycho-emotional depressive disorders in the acute and late recovery period of ischemic stroke using NIHSS scales, Bartel index, modified Rankin scale, RASS scale. Statistical analysis of the obtained data was performed using the Spearman correlation coefficient, multiple regression analysis, descriptive statistics methods.
Results. The risk factors for depression in the early recovery period after ischemic stroke and the association of post-stroke depression (PSD) with the risk of recurrence have been identified. 771 stroke patients (13%) had anxiety-depressive syndrome: 436 (56%) man, 335 (44%) women. PSD has been found to be more pronounced in old people, female, single patients. The development of PSD is influenced by many factors, including severity of stroke, disease course, significant functional impairment and degree of disability, reduced cognitive, language functions, and dependence on outsiders. The more pronounced severity of PSD is related to the degree of functional dependence and language-cognitive status.
Conclusions. The presence of PSD results in worst prognosis of stroke of functional and cognetiv renewal of patients, increases their dependence on an extraneous help, considerably worsens quality of life. The origin of PSD has multifactorial genesis, mostly psychogenicsocial factor, influences on the degree of functional dependence of patients, especially aphasia. Influence on risk factors will give an opportunity to prevent development of PSD will promote it to effective rehabilitation and prevantion of repeated ischemic stroke.
Keywords: ischemic stroke, psychogenic factors, post-stroke depression, principles of rehabilitation, treatment, prevention.
Access to books and English reading: A virtuous circle
Authors: Cho Kyung Sook , Krashen Stephen
Published: June 2020

The hypothesis explored in this paper is whether a “virtuous circle” can be established to promote English language development: providing access to interesting and comprehensible reading material, which in turn will increase reading English books, which in turn will promote English competence and in turn more reading of English books. Specifically, we seek to determine if those with more access to English books at home and through visits to bookstores show more interest in reading, and in turn are more supportive of having an English library at their school.  Analysis of responses of sixth graders at four schools in Korea revealed little access to English reading material, but supported the virtuous circle hypothesis, suggesting that the path to high English competence may be easier to establish than we have imagined.
Prácticas, saberes y apropiación del medio audiovisual en los colectivos de comunicación comunitaria de la ciudad de Medellín
Authors: Lopera Rueda Juan Gonzalo
Published: June 2020

En el artículo se presenta la reflexión producto de investigación de las prácticas, saberes y apropiación que del audiovisual agencian los colectivos de comunicación comunitaria: ComúnAudiovisual, Pasolini en Medellín y Mancha Negra, todos ellos con incidencia en barrios periféricos de la ciudad de Medellín. Los audiovisuales de estos colectivos son el resultado de procesos investigativos y metodológicos realizados en amalgama con la comunidad. Esos Audiovisuales Comunitarios (AC); Documentales Sociales Participativos (DSP); Documentales Etnográficos (DE) contienen la memoria y vivencias de las comunidades. Inciden en la identidad y construcción del tejido social comunitario. Comunicación otra, aquella del buen vivir, el cambio social que impulsa a expresarse y al diálogo de saberes.
Thermal ionization energy of hydrogen-like impurities in semiconductor materials
Authors: Poklonski Nikolai A. , Vyrko Sergey A. , Dzeraviaha Aliaksandr N.
Published: June 2020

In the work the dependence of the thermal ionization energy of hydrogen-like donors and acceptors on their concentration in n- and p-type semiconductors is analyzed analytically and numerically. The impurity concentrations and temperatures at which the semiconductors are on the insulator side of the concentration insulator – metal phase transition (Mott transition) are considered. It is assumed that impurities in the crystal are distributed randomly (according to Poisson), and their energy levels are distributed normally (according to Gauss). In the quasi-classical approximation, it is shown, for the first time, that the decrease in the ionization energy of impurities mainly occurs due to the joint manifestation of two reasons. Firstly, from the excited states of electrically neutral impurities, a quasicontinuous band of allowed energy values is formed for c-band electrons in an n-type crystal (or for v-band holes in a p-type crystal). This reduces the energy required for the thermally activated transition of electron from the donor to the c-band (for the transition of the hole from the acceptor to the v-band). Secondly, from the ground (unexcited) states of impurities a classical impurity band is formed, the width of which at low temperatures is determined only by the concentration of impurity ions. In moderately compensated semiconductors (when the ratio of the concentration of minority impurities to the concentration of majority impurities is less than 50 %) the Fermi level is located closer to the edge of the band of allowed energy values than the middle of the impurity band, that issue reduces thermal ionization energy of impurities from states in the vicinity of the Fermi level (transition of electron from a donor to the c-band, or hole from an acceptor to the v-band). Previously, these two causes of decrease in the thermal ionization energy due to increase in the concentration of impurities were considered separately. The results of calculations according to the proposed formulas are quantitatively agree with the known experimental data for a number of semiconductor materials (germanium, silicon, diamond, gallium arsenide and phosphide, silicon carbide, zinc selenide) with a moderate compensation ratio.
The influence of external electrostatic field on the combustion of hexamine
Authors: Zur Ilya A. , Fedotov Alexander S.
Published: June 2020

In scientific work investigates the impact of electric fields on combustion of hexamine. The experimental setup has been developed to study the interaction of an electric field with a low-temperature flame. The optimal spatial configuration of the electrodes for extinguishing the flame was established; the dynamics of airflows caused by the ion wind was studied; the threshold value of the electric field leading to flame extinguishing was determined. An expression is proposed based on the equation of motion that connects the speed of motion of partially ionized gas particles, the viscosity and degree of ionization of the gas, and the intensity of the external electric field. It is shown that the strength of the external electric field, leading to extinguishing of hexamine combustion, increases with decreasing inter-electrode space. The values of corresponding electric field strength lied in range from 80 to 135 kV/m at interelectrode distances of 0.4 and 0.1 m, respectively. The results of the study can be used for effective fire extinguishing in compact devices running on dry fuel.
Classical instanton solutions in quantum field theory
Authors: Shulyakovsky Roman G. , Gribowsky Alexander S. , Garkun Alexander S. , Nevmerzhitsky Maxim N. , Shaplov Alexei O. , Shohonov Denis A.
Published: June 2020

Instantons are non-trivial solutions of classical Euclidean equations of motion with a finite action. They provide stationary phase points in the path integral for tunnel amplitude between two topologically distinct vacua. It make them useful in many applications of quantum theory, especially for describing the wave function of systems with a degenerate vacua in the framework of the path integrals formalism. Our goal is to introduce the current situation about research on instantons and prepare for experiments. In this paper we give a review of instanton effects in quantum theory. We find in stanton solutions in some quantum mechanical problems, namely, in the problems of the one-dimensional motion of a particle in two-well and periodic potentials. We describe known instantons in quantum field theory that arise, in particular, in the two-dimensional Abelian Higgs model and in SU(2) Yang – Mills gauge fields. We find instanton solutions of two-dimensional scalar field models with sine-Gordon and double-well potentials in a limited spatial volume. We show that accounting of instantons significantly changes the form of the Yukawa potential for the sine-Gordon model in two dimensions.
Influence of salt structures on the location of glacial valleys within the Pripyat Trough (Belarus)
Authors: Комаровский Михаил Евгеньевич
Published: June 2020

It was found that glacial valleys in the Pripyat Trough are connected with the location of the halokinetic structures of the Upper-Famennian salt strata. Valleys were noticed over salt structures, which developed during the Quaternary. The most part of valleys is over salt diapires, pillows and swells, rarer they occur within synclinales and troughs. Within local anticlinales valleys focus mainly in its tops and limbs, which have incline down glacier. Within salt synclinales valleys lie over its axis and limbs, which are connected with adjacent anticlinales. The most typical regularities of the glacial valleys localization within the salt structures is their close connection with active fault systems. These faults propagate upwards from the tops and flanks of diapires across the Upper-Famennian and supra-salt overburden into the Quaternary, where underlie the valleys. The developing of salt structures and faults during the Narev and Dnieper glaciations created weakness zones in glacial bed that facilitated erosion by the glaciers and subglacial melt water.
Heat flow of Uzbekistan: geology and interpretation
Authors: Zui Vladimir I. , Andreyev Dmitriy N. , Rakhmatullayev Khikmatilla Kh.
Published: June 2020

The first determinations of the heat flow density in Uzbekistan, as well as in Central Asia as a whole, were carried out in the middle 1960s. In subsequent years, many researchers, primarily in connection with the search and exploration of oil and natural gas deposits, studied the geothermal field of the region. The data accumulated to date show a significant heterogeneity of the thermal field in both Uzbekistan and the adjacent territory of Central Asia. Rare wells were studied in the desert areas of Kyzyl Kum and Kara Kum. The heat flow in Uzbekistan varies over a wide range from 20–30 to approximately 100 mW/m2. Its high values are characteristic of intermountain depressions and blocks of the earth’s crust with a dense network of deep faults. The heat flow increases significantly in the southern and eastern parts of Uzbekistan, as well as in the neighbouring territories adjacent to the mountain structures of the Tien Shan and Pamir, characterized by high seismicity, tectonic and thermal activation. An updated map of the heat flow density of Uzbekistan was compiled and, separately for the Fergana Depression. They reflect a significant regional variability of the geothermal field. With the transition from the relatively flat territory of the Turanian Plate to mountain structures, the degree of differentiation by the heat flow increases significantly. This is typical of the entire orogenic Alpine-Himalayan Belt.
1961-1965 Arasında Türkiye Solunda Eğitim Tartışmaları
Authors: ÖZTAN Güven Gürkan
Published: June 2020

1961 Anayasası’nın yürürlüğe girmesini takip eden süreçte sol/sosyalist fikirler görünürlük kazanmıştır. 1960’ların ilk yarısında örgütlenme faaliyetlerine yoğunlaşan sol çevreler Anayasanınkazanımlarının korunması, planlı kalkınma hedefinin gerçekleştirilmesi ve toplumsal eşitsizliklerin merkezi politikalarla giderilmesi konusunda benzer fikirlere sahip olmuştur. Eğitim sisteminin yeniden yapılandırılması bu hedeflere ulaşabilmenin ön şartlarından biri olarak düşünülmüştür.Bu çalışmada 1961-1965 arasındaki dönemde sol/sosyalist siyasetin eğitim başlığını hangi ekonomi politik bağlamda ve hangi temel başlıklar altında ele aldığı incelenecektir. Sözü edilen amaca uygun olarak Yön Dergisi’ne, TİP çevresinin çıkardığı Sosyal Adalet Dergisi’ne TİP’in ve CHP’nin parti programı, bildiri ve seçim beyannamelerine, gazete arşivlerine başvurulacaktır. Türkiye solunun eğitime yüklediği misyon, planlı kalkınma, anti-emperyalizm ve sosyal adalet gibi dönemin sık başvurulan kavramları etrafında tartışılacaktır. Eğitim sistemindeki ABD etkisine ve anti-komünizm uygulamalarına karşı tepkilere, Köy Enstitülerinin yeniden açılması taleplerine, halkçı eğitim tartışmalarına yer verilecek, bu dönemde yükseköğretime dair sorunların sol/sosyalist dergilerde ve partilerde nasıl ele alındığı incelenecektir.
Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19
Authors: Samoilov A. S. , Udalov Yu. D. , Sheyanov M. V. , Gholinsky A. V. , Litvinenko A. B.
Published: June 2020

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.
The Evacuation of Children inside Wartime France
Authors: Dodd Lindsey
Published: June 2020

This article explores the evacuation of children from the Paris region to the rural Creuse département, prompted by problems with the capital's food supply and increasingly heavy Allied air raids from 1943. It combines archival material and oral narratives, using the case studies of two individuals (Françoise and Christian) to suggest first, a latent archival bias towards extremes of positive and negative experience, and second, the ways oral history narratives can provide nuance and texture to how we understand the past, replicating more faithfully the equivocal nature of everyday life. After an outline of the historical context of evacuation, three aspects of the evacuee-host experience are considered: the decision to accept an evacuee, the material conditions in which the child was accommodated, and the longer-term relationships forged through evacuation. It is both an analysis of some of the historical dimensions of children's evacuation and a methodological exploration of oral and written data.
QEXAFS method implementation using adaptive X-ray optical elements
Authors: Protsenko A I , Blagov A E , Pisarevsky Yu V , Rogachev A V , Targonsky A V , Trigub A L , Eliovich I A , Yakunin S N , Kovalchuk M V
Published: June 2020

A modification of the of high-speed high-resolution X-ray absorption spectroscopy (Quick Extended X-ray Absorption Fine Structure, QEXAFS) method based on an adaptive bending element of X-ray optics is described. This technique was implemented at the Langmuir station of the Kurchatov Synchrotron Radiation Source (KISI-Kurchatov). The absorption spectrum of a model sample, bromine in a sodium bromide compound, was recorded. A recording speed up to 5 seconds per spectrum was achieved in the continuously recording regime. The method is applicable for obtaining information about both the structure and dynamics of a wide range of objects, ordered and disordered, in any aggregate state.
Determination of Fish Consumption Habits of Consumers: Case Study of Mary City, Turkmenistan
Authors: AYDIN Ahmet , BASHİMOV Güçgeldi
Published: June 2020

The aim of this study was to determine the habits of families towards fish consumption in urban areas of Mary city in Turkmenistan. The main data of this study has been compiled by asking 20 questions to 267 consumers who lived in Mary city. Predetermined questions were applied to randomly selected people as question-answer. Sample size of this study was determined with unclustered probability sampling method. According to the research findings, yearly fish consumption of the examined consumers was determined as 3.28 kg per capita. Mostly preferred fish are catfish, herring and grey mullet respectively. Consumers preferred bazaars the most and markets the least as a place to purchase fish. 97% consumers consume fresh fish while 64.79% consume fish by frying. While 56.55% of consumers think that fish prices are high, 34.46% of consumers think it is normal. At the end of the study, it is obtained some results relevant to participant’s average monthly income, educational background, their professional status, marital status, types of supplying and consuming fish, cooking methods and attitude towards fish consumption.
Sybil: Spider at the Center of PALE FIRE's Web of Sense Archetype, Alchemy, & Allegory: The Jungian Substrate of Nabokov’s PALE FIRE. Part II
Authors: Ross Mary
Published: June 2020

With both his vaunted persona (Shade) and his vile shadow (Gradus) dead, Kinbote cries, “God will help me, I trust, to rid myself of any desire to follow the example of the two other characters in this work. I shall continue to exist.” However, now, more than ever, it seems Kinbote is threatened by an even greater repressed unconscious, a “bigger, more respectable, more competent Gradus.” If Kinbote indeed suicides hors texte, as Nabokov claimed “he certainly did,” that would indicate, on the archetypal antithetic level, an “ego-death” of transcendence and transformation, that is, Jungian individuation. Has he, in death, managed to avoid this conflict? Who is this great looming shadow? The missing piece, the “masterpiece” for individuation is the contrasexual archetype, the anima. I suggest this is none other than Charles Kinbote’s most formidable antagonist, Sybil Shade, the spider at the center of PALE FIRE’s “web of sense.”
Peripheral vitreochorioretinal dystrophy in patients with various types of myopia
Authors: Myagkov Alexander , Serebrennikova Elena , Poskrebysheva Zhanna , Sharoglazova Maria
Published: June 2020

Background. Over the past decade, there has been an in¬crease in myopia prevalence in the world; in many countries it is considered as epidemic. In case of an unfavorable course, myopia becomes the cause of retinal pathology, which in se¬vere cases leads to an irreversible decrease in corrected visu¬al acuity and to visual impairment that occurs at working age.
Purpose. To analyze the relationship between the occurrence of peripheral vitreochorioretinal dystrophy (PVCD) in patients with myopia depending on its type: refractive and axial.
Material and methods. A retrospective cohort analysis involved 304 patients (608 eyes) of 13 to 70 years old with acquired myopia: mild (19.40%), moderate (42.93%) and high (37.67%). In all cases, myopia was complicated by PVCD. All patients were divided into 2 groups according to the type of myopia: refractive and axial myopia. Biometric data (LENSTAR LS 900) and keratometry (“Huvitz”, South Korea) were used as criteria for patient selection.
Results. The distribution of patients showed that PVCD most often occurs in the group of patients with axial myopia of moderate (44.48%) and high (39.70%) degrees. In the group of patients with mild axial myopia, the incidence was 15.80%. A clear correlation was noted between the development of PVCD and the axial elongation.
In contrast, in patients with refractive myopia, the incidence of PVCD was two times higher in case of mild myopia (50.00%) than in cases of moderate (29.69%) and high myopia (20.31%) put together.
Conclusion. The study revealed that PVCD is almost 8,5 times more likely to occur in case of axial myopia than in case of refractive myopia. A possible cause of PVCD development in case of axial myopia is an increase in the axial length, while in case of refractive myopia its possible cause is the increase in the eyeball’s transverse size. Regardless of the type of myopia and its degree, the study of the periphery of the retina is an essential element of diagnostics for timely detection of PVCD and monitoring the progression of axial myopia is an important criterion for its prevention.
Blood-Based Biomarkers Predictive of Metformin Target Engagement in Fragile X Syndrome
Authors: Jasoliya Mittal , Bowling Heather , Petrasic Ignacio Cortina , Durbin-Johnson Blythe , Klann Eric , Bhattacharya Aditi , Hagerman Randi , Tassone Flora
Published: June 2020

Recent advances in neurobiology have provided several molecular entrees for targeted treatments for Fragile X syndrome (FXS). However, the efficacy of these treatments has been demonstrated mainly in animal models and has not been consistently predictive of targeted drugs’ response in the preponderance of human clinical trials. Because of the heterogeneity of FXS at various levels, including the molecular level, phenotypic manifestation, and drug response, it is critically important to identify biomarkers that can help in patient stratification and prediction of therapeutic efficacy. The primary objective of this study was to assess the ability of molecular biomarkers to predict phenotypic subgroups, symptom severity, and treatment response to metformin in clinically treated patients with FXS. We specifically tested a triplex protein array comprising of hexokinase 1 (HK1), RAS (all isoforms), and Matrix Metalloproteinase 9 (MMP9) that we previously demonstrated were dysregulated in the FXS mouse model and in blood samples from patient with FXS. Seventeen participants with FXS, 12 males and 5 females, treated clinically with metformin were included in this study. The disruption in expression abundance of these proteins was normalized and associated with significant self-reported improvement in clinical phenotypes (CGI-I in addition to BMI) in a subset of participants with FXS. Our preliminary findings suggest that these proteins are of strong molecular relevance to the FXS pathology that could make them useful molecular biomarkers for this syndrome.
Time is on My Side—or Is It? Assessing How Perceived Control of Time and Procrastination Influence Emotional Exhaustion on the Job
Authors: Roster Catherine A. , Ferrari Joseph R.
Published: June 2020

The job demands–control model (JDC) postulates that an increased control over work resources mitigates or “buffers” the positive association between job stressors and strainers. However, the inconclusive validation of the buffering hypothesis across multiple studies suggests the need for fresh approaches, both conceptual and methodological. We integrated aspects of the JDC framework and time management process models to construct a model that tested both the direct and indirect effects of the perceived control of time (PCT) on emotional exhaustion arising from workload demands. Furthermore, we tested whether procrastination tendencies moderated the benefits of PCT on work stressors and strains. Data were collected in an Internet survey with 356 US adult office workers obtained from Prolific. The results supported the buffering effect of PCT on emotional exhaustion. PCT both mediated and exerted direct effects on the relationship between workload and emotional exhaustion. Procrastination tendencies moderated PCT and, in turn, undermined high PCT ability to reduce emotional exhaustion. Overall, the findings suggested that giving workers more control over their time may reduce stress associated with demanding workloads. However, chronic procrastinators may benefit less from having more control over time resources if they are not provided with tools to help them self-regulate more effectively.
Small Non-Coding RNA Profiling in Plasma Extracellular Vesicles of Bladder Cancer Patients by Next-Generation Sequencing: Expression Levels of miR-126-3p and piR-5936 Increase with Higher Histologic Grades
Authors: Sabo Alexandru A. , Birolo Giovanni , Naccarati Alessio , Dragomir Mihnea P. , Aneli Serena , Allione Alessandra , Oderda Marco , Allasia Marco , Gontero Paolo , Sacerdote Carlotta , Vineis Paolo , Matullo Giuseppe , Pardini Barbara
Published: June 2020

Bladder cancer (BC) is the tenth most frequent cancer worldwide. Due to the need for recurrent cystoscopies and the lack of non-invasive biomarkers, BC is associated with a high management burden. In this respect, small non-coding RNAs (sncRNAs) have been investigated in urine as possible biomarkers for BC, but in plasma their potential has not yet been defined. The expression levels of sncRNAs contained in plasma extracellular vesicles (EVs) from 47 men with BC and 46 healthy controls were assessed by next-generation sequencing. The sncRNA profiles were compared with urinary profiles from the same subjects. miR-4508 resulted downregulated in plasma EVs of muscle-invasive BC patients, compared to controls (adj-p = 0.04). In World Health Organization (WHO) grade 3 (G3) BC, miR-126-3p was upregulated both in plasma EVs and urine, when compared to controls (for both, adj-p < 0.05). Interestingly, two sncRNAs were associated with the risk class: miR-4508 with a downward trend going from controls to high risk BC, and piR-hsa-5936 with an upward trend (adj-p = 0.04 and adj-p = 0.05, respectively). Additionally, BC cases with low expression of miR-185-5p and miR-106a-5p or high expression of miR-10b-5p showed shorter survival (adj-p = 0.0013, adj-p = 0.039 and adj-p = 0.047, respectively). SncRNAs from plasma EVs could be diagnostic biomarkers for BC, especially in advanced grade.
Development of Folate Receptor−Targeted PET Radiopharmaceuticals for Tumor Imaging—A Bench-to-Bedside Journey
Authors: Boss Silvan D. , Ametamey Simon Mensah
Published: June 2020

The folate receptor-α (FR-α) is overexpressed in many epithelial cancers, including ovary, uterus, kidneys, breast, lung, colon and prostate carcinomas, but shows limited expression in normal tissues such as kidneys, salivary glands, choroid plexus and placenta. FR-α has therefore emerged as a promising target for the delivery of therapeutic and imaging agents to FR-positive tumors. A series of folate-based PET (positron emission tomography) radiopharmaceuticals have been developed for the selective targeting of FR-positive malignancies. This review provides an overview on the research progress made so far regarding the design, radiosynthesis and the utility of the folate-derived PET radioconjugates for targeting FR-positive tumors. For the most part, results from folate radioconjugates labeled with fluorine-18 (t1/2 = 109.8 min) and gallium-68 (t1/2 = 67.7 min) have been presented but folates labeled with “exotic” and new PET radionuclides such as copper-64 (t1/2 = 12.7 h), terbium-152 (t1/2 = 17.5 h), scandium-44 (t1/2 = 3.97 h), cobalt-55 (t1/2 = 17.5 h) and zirconium-89 (t1/2 = 78.4 h) are also discussed. For tumor imaging, none of the reported PET radiolabeled folates reported to date has made the complete bench-to-bedside journey except [18F]AzaFol, which made it to patients with metastatic ovarian and lung cancers in a multicenter first-in-human trial. In the near future, however, we expect more clinical trials with folate-based PET radiopharmaceuticals given the increasing clinical interest in imaging and the treatment of FR-related malignancies.
Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer
Authors: Le Thiec Maelle , Testard Aude , Ferrer Ludovic , Guillerminet Camille , Morel Olivier , Maucherat Bruno , Rusu Daniela , Girault Sylvie , Lacombe Marie , Hamidou Hadji , Meyer Véronique , Rio Emmanuel , Hiret Sandrine , Kraeber-Bodéré Françoise , Campion Loïc , Rousseau Caroline
Published: June 2020

Due to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squamous cell carcinoma (SCC). Eighty-one patients with FDG-PET before radiochemotherapy were retrospectively analyzed. Semiquantitative data were measured with three fixed thresholds (35%, 41% and 50% of Maximum Standardized Uptake Value (SUVmax)) and four segmentation methods based on iterative approaches (Black, Adaptive, Nestle and Fitting). Metabolic volumes of primary anal tumour (P-MTV) and total tumour load (T-MTV: P-MTV+ lymph node MTV) were calculated. The primary endpoint was event-free survival (EFS). Seven multivariate models were created to compare FDG-PET tumour volumes prognostic impact. For all segmentation thresholds, PET metabolic volume parameters were independent prognostic factor and T-MTV variable was consistently better associated with EFS than P-MTV. Patient’s sex was an independent variable and significantly correlated with EFS. With fixed threshold segmentation methods, 35% of SUVmax threshold seemed better correlated with EFS and the best cut-off for discrimination between a low and high risk of event occurrence was 40 cm3. Determination of T-MTV by FDG-PET using fixed threshold segmentation is useful for predicting EFS for primary anal SCC. If these data are confirmed in larger studies, FDG-PET could contribute to individualized patient therapies.
The Role of Alternative RNA Splicing in the Regulation of hTERT, Telomerase, and Telomeres: Implications for Cancer Therapeutics
Authors: Slusher Aaron L. , Kim Jeongjin JJ , Ludlow Andrew T.
Published: June 2020

Alternative RNA splicing impacts the majority (>90%) of eukaryotic multi-exon genes, expanding the coding capacity and regulating the abundance of gene isoforms. Telomerase (hTERT) is a key example of a gene that is alternatively spliced during human fetal development and becomes dysregulated in nearly all cancers. Approximately 90% of human tumors use telomerase to synthesize de novo telomere repeats and obtain telomere-dependent cellular immortality. Paradigm shifting data indicates that hTERT alternative splicing, in addition to transcription, plays an important role in the regulation of active telomerase in cells. Our group and others are pursuing the basic science studies to progress this emerging area of telomerase biology. Recent evidence demonstrates that switching splicing of hTERT from the telomerase activity producing full-length hTERT isoform to alternatively spliced, non-coding isoforms may be a novel telomerase inhibition strategy to prevent cancer growth and survival. Thus, the goals of this review are to detail the general roles of telomerase in cancer development, explore the emerging regulatory mechanisms of alternative RNA splicing of the hTERT gene in various somatic and cancer cell types, define the known and potential roles of hTERT splice isoforms in cancer cell biology, and provide insight into new treatment strategies targeting hTERT in telomerase-positive cancers.
Dual Targeting of BRAF and mTOR Signaling in Melanoma Cells with Pyridinyl Imidazole Compounds
Authors: Palušová Veronika , Renzová Tereza , Verlande Amandine , Vaclová Tereza , Medková Michaela , Cetlová Linda , Sedláčková Miroslava , Hříbková Hana , Slaninová Iva , Krutá Miriama , Rotrekl Vladimír , Uhlířová Hana , Křížová Aneta , Chmelík Radim , Veselý Pavel , Krafčíková Michaela , Trantírek Lukáš , Schink Kay Oliver , Uldrijan Stjepan
Published: June 2020

BRAF inhibitors can delay the progression of metastatic melanoma, but resistance usually emerges, leading to relapse. Drugs simultaneously targeting two or more pathways essential for cancer growth could slow or prevent the development of resistant clones. Here, we identified pyridinyl imidazole compounds SB202190, SB203580, and SB590885 as dual inhibitors of critical proliferative pathways in human melanoma cells bearing the V600E activating mutation of BRAF kinase. We found that the drugs simultaneously disrupt the BRAF V600E-driven extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) activity and the mechanistic target of rapamycin complex 1 (mTORC1) signaling in melanoma cells. Pyridinyl imidazole compounds directly inhibit BRAF V600E kinase. Moreover, they interfere with the endolysosomal compartment, promoting the accumulation of large acidic vacuole-like vesicles and dynamic changes in mTOR signaling. A transient increase in mTORC1 activity is followed by the enrichment of the Ragulator complex protein p18/LAMTOR1 at contact sites of large vesicles and delocalization of mTOR from the lysosomes. The induced disruption of the endolysosomal pathway not only disrupts mTORC1 signaling, but also renders melanoma cells sensitive to endoplasmic reticulum (ER) stress. Our findings identify new activities of pharmacologically relevant small molecule compounds and provide a biological rationale for the development of anti-melanoma therapeutics based on the pyridinyl imidazole core.