bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating Drought Events and Their Consequences in Wildfires: An Application in China
Authors: Yang Song , Zeng Aicong , Tigabu Mulualem , Wang Guangyu , Zhang Zhen , Zhu He , Guo Futao
Published: June 2023

Understanding the impact of drought on fire dynamics is crucial for assessing the potential effects of climate change on wildfire activity in China. In this study, we present a series of multiple linear regression (MLR) models linking burned area (BA) during mainland China’s fire season from 2001 to 2019, across seven regions, to concurrent drought, antecedent drought, and time trend. We estimated burned area using Collection 6 Moderate Resolution Imaging Spectradiometer (MODIS) and drought indicators using either the Standardized Precipitation Evapotranspiration Index (SPEI) or the self-calibrated Palmer Drought Severity Index (sc-PDSI). Our findings indicate that the wildfire season displays a spatial variation pattern that increases with latitude, with the Northeast China (NEC), North China (NC), and Central China (CC) regions identified as the primary areas of wildfire occurrence. Concurrent and antecedent drought conditions were found to have varying effects across regions, with concurrent drought as the dominant predictor for NEC and Southeast China (SEC) regions and antecedent drought as the key predictor for most regions. We also found that the Northwest China (NWC) and CC regions exhibit a gradual decrease in burned area over time, while the NEC region showed a slight increase. Our multiple linear regression models exhibited a notable level of predictive power, as evidenced by the average correlation coefficient of 0.63 between the leave-one-out cross-validation predictions and observed values. In particular, the NEC, NWC, and CC regions demonstrated strong correlations of 0.88, 0.80, and 0.76, respectively. This indicates the potential of our models to contribute to the prediction of future wildfire occurrences and the development of effective wildfire management and prevention strategies. Nevertheless, the intricate relationship among fire, climate change, human activities, and vegetation distribution may limit the generalizability of these findings to other conditions. Consequently, future research should consider a broad range of factors to develop more comprehensive models.
An Analysis of Socioeconomic Determinants of the Black–White Disparity in Food Insecurity Rates in the US
Authors: Price Mya , Jeffery Tia
Published: June 2023

Previous research has not fully explored socioeconomic factors that influence the Black–White food insecurity disparities at the state and county levels in the United States. The goal of this study was to identify socioeconomic determinants associated with the Black–White food insecurity gap in the US at the state and county levels with rigorous quantitative investigation. The 2019 Map the Meal Gap dataset and multivariate regression analyses were used to identify factors associated with the prevalence of the Black–White disparity in food insecurity rates. Unemployment rate and median income gaps were found to be the strongest predictors of the Black–White disparity in food insecurity and the Black food insecurity rates in both state- and county-level models. Specifically, a 1% increase in Black unemployment rate compared with White unemployment rate was associated with a 0.918% and 0.232% increase in the Black–White disparity in food insecurity on average at the state and county levels, respectively. This study highlights the potential root causes of food insecurity and significant socioeconomic determinants associated with the Black–White food insecurity gap at the state and county levels in the US. Policymakers and program creators should implement action plans to address the income disparities and reduce unemployment rates among Blacks to eradicate this gap and ensure equity in food access between Blacks and Whites.
Koelreuteria paniculata Seed Oil—A Rich Natural Source of Unsaturated Fatty Acids and Phytocompounds with DNA Protective Potential
Authors: Andonova Tsvetelina , Muhovski Yordan , Apostolova Elena , Naimov Samir , Petkova Zhana , Teneva Olga , Antova Ginka , Slavov Iliya , Dimitrova-Dyulgerova Ivanka
Published: June 2023

The present work is focused on the physicochemical characteristics, chemical composition, and some biological activities of Koelreuteria paniculata seed oil. The glyceride oil, obtained with a Soxhlet apparatus by extraction with hexane, was characterized by a relatively high oil content (over 20%), and it is defined as a non-drying oil (iodine value—44 gI2/100 g) with good oxidative stability (over 50 h). There were identified 11 fatty acids, 6 sterols, 3 tocopherols, and 6 phospholipids, as the last group was reported for the first time. The major components among them were—monounsaturated eicosenoic and oleic acids, β-sitosterol, β-tocopherol, and phosphatidylcholine. The in vitro tests demonstrated DNA protective activity and a lack of cytotoxicity of the oil, data that has been reported for the first time. The in vitro MTT test of the oil on HT-29 and PC3 cell lines did not indicate antitumor activity. The seed oil studied contains valuable bio-components, which have proven benefits for human health, and that is why it could be used in food, cosmetic, and pharmaceutical products.
Transmembrane Pressure during Micro- and Diafiltration of Milk Affects the Release of Non-Sedimentable Caseins
Authors: Raak Norbert , Coşkun Özgenur , Corredig Milena
Published: June 2023

Membrane filtration, especially in combination with diafiltration, can affect the colloidal structure of casein micelles in milk and concentrated milks. The partial dissociation of casein proteins from the casein micelles into the serum phase has been shown to depend on diafiltration conditions. This dissociation can affect the technological functionality of the milk concentrates. The present study aimed at determining the contribution of the gel layer deposited onto the membrane during filtration in the colloidal equilibrium between soluble and micellar caseins. Skimmed milk was concentrated by microfiltration combined with diafiltration using a cross-flow spiral-wound membrane at two transmembrane pressure (TMP) levels, causing differences in the extent of the gel layer formed. Non-sedimentable casein aggregates were formed to a greater extent at a low TMP compared to a high operating TMP. This difference was attributed to the greater compression of the deposit layer during filtration at a high TMP. This study contributes new knowledge to the understanding of how to modulate the functionality of milk concentrates through the control of processing conditions.
High-Power Ultrasound in Enology: Is the Outcome of This Technique Dependent on Grape Variety?
Authors: Pérez-Porras Paula , Gómez Plaza Encarna , Martínez-Lapuente Leticia , Ayestarán Belén , Guadalupe Zenaida , Jurado Ricardo , Bautista-Ortín Ana Belén
Published: June 2023

The disruptive effect exerted by high-power ultrasound (US) on grape cell walls is established as the reason behind the chromatic, aromatic and mouthfeel improvement that this treatment causes in red wines. Given the biochemical differences that exist between the cell walls of different grape varieties, this paper investigates whether the effect of the application of US in a winery may vary according to the grape variety treated. Wines were elaborated with Monastrell, Syrah and Cabernet Sauvignon grapes, applying a sonication treatment to the crushed grapes using industrial-scale equipment. The results showed a clear varietal effect. The wines made with sonicated Syrah and Cabernet Sauvignon grapes showed an important increase in the values of color intensity and concentration of phenolic compounds, and these increases were higher than those observed when sonication was applied to Monastrell crushed grapes, whereas Monastrell wines presented the highest concentration in different families of polysaccharides. These findings correlate with the differences in the composition and structure of their cell walls since those of Monastrell grapes presented biochemical characteristics associated with a greater rigidity and firmness of the structures.
Faba Bean Flavor Effects from Processing to Consumer Acceptability
Authors: Badjona Abraham , Bradshaw Robert , Millman Caroline , Howarth Martin , Dubey Bipro
Published: June 2023

Faba beans as an alternative source of protein have received significant attention from consumers and the food industry. Flavor represents a major driving force that hinders the utilization faba beans in various products due to off-flavor. Off-flavors are produced from degradation of amino acids and unsaturated fatty acids during seed development and post-harvest processing stages (storage, dehulling, thermal treatment, and protein extraction). In this review, we discuss the current state of knowledge on the aroma of faba bean ingredients and various aspects, such as cultivar, processing, and product formulation that influence flavour. Germination, fermentation, and pH modulation were identified as promising methods to improve overall flavor and bitter compounds. The probable pathway in controlling off-flavor evolution during processing has also been discussed to provide efficient strategies to limit their impact and to encourage the use of faba bean ingredients in healthy food design.
Transcriptome Co-Expression Network Analysis of Peach Fruit with Different Sugar Concentrations Reveals Key Regulators in Sugar Metabolism Involved in Cold Tolerance
Authors: Wang Lufan , Zheng Xiaolin , Ye Zhengwen , Su Mingshen , Zhang Xianan , Du Jihong , Li Xiongwei , Zhou Huijuan , Huan Chen
Published: June 2023

Peach fruits are known to be highly susceptible to chilling injury (CI) during low-temperature storage, which has been linked to the level of sugar concentration in the fruit. In order to better understand the relationship between sugar metabolism and CI, we conducted a study examining the concentration of sucrose, fructose, and glucose in peach fruit with different sugar concentrations and examined their relationship with CI. Through transcriptome sequencing, we screened the functional genes and transcription factors (TFs) involved in the sugar metabolism pathway that may cause CI in peach fruit. Our results identified five key functional genes (PpSS, PpINV, PpMGAM, PpFRK, and PpHXK) and eight TFs (PpMYB1/3, PpMYB-related1, PpWRKY4, PpbZIP1/2/3, and PpbHLH2) that are associated with sugar metabolism and CI development. The analysis of co-expression network mapping and binding site prediction identified the most likely associations between these TFs and functional genes. This study provides insights into the metabolic and molecular mechanisms regulating sugar changes in peach fruit with different sugar concentrations and presents potential targets for breeding high-sugar and cold-tolerant peach varieties.
Stability and Digestive Properties of a Dual-Protein Emulsion System Based on Soy Protein Isolate and Whey Protein Isolate
Authors: Gao Ting-Ting , Liu Jing-Xue , Gao Xin , Zhang Guo-Qi , Tang Xiao-Zhi
Published: June 2023

The stability and digestive properties of a dual-protein emulsion consisting of soy protein isolate (SPI) and whey protein isolate (WPI) have been systematically studied. The results showed that the particle size and viscosity of the dual-protein emulsion system decreased continuously with the increase in WPI, and this might be related to the large amount of electric charge on the surface of the emulsion droplets. Dual-protein emulsions with ratios of 3:7 and 5:5 showed the highest emulsion activity, while emulsion stability increased with the increase in WPI. The thicker adsorption layer formed at the interface might have contributed to this phenomenon. After in-vitro-simulated digestion, the emulsion droplet particle size increased substantially due to the weakened electrostatic repulsion on the droplet surface, especially for the intestinal digestion phase. Meanwhile, WPI accelerated the release of free fatty acids in the digestion process, which played a positive role in the nutritional value of the dual-protein emulsion. In accelerated oxidation experiments, WPI also improved the antioxidant properties of the dual-protein emulsion system. This study will provide a new insight and necessary theoretical basis for the preparation of dual-protein emulsions.
The Effect of Response Conditions on Food Images-Evoked Emotions Measured Using the Valence × Arousal Circumplex-Inspired Emotion Questionnaire (CEQ)
Authors: Seo Han-Seok , Rockers Lydia , Kim Young-Gab
Published: June 2023

In 2020, a single-response-based, valence × arousal circumplex-inspired emotion questionnaire (CEQ) was developed. Using a between-participants design, previous studies have found that a multiple response (MR) condition better discriminated test samples (e.g., written food names) based on their evoked emotions than a single response (SR) condition. This research, comprising Studies 1 and 2, aimed to determine the effect of response conditions (i.e., SR vs. MR) on emotional responses to food image samples, using a within-participants design. In Study 1, 105 Korean participants were asked to select a pair of emotion terms (i.e., SR condition) or select all pairs representing their evoked emotions (i.e., MR condition) from a list of 12 pairs of emotion terms of the CEQ, in response to the 14 food images. Both SR and MR conditions were tested within a remote (online) session. To minimize both a potential carry-over effect of the “within-participants design” and an influence of environmental factors in the remote testing, Study 2 asked 64 U.S. participants to do so over two separated sessions on two different days in a controlled laboratory setting. In both Studies 1 and 2, participants selected the CEQ’s emotion-term pairs in the MR condition more frequently than in the SR condition, leading to the MR condition’s higher capacity to discriminate test samples. While the configurations of the correspondence analysis biplots drawn in the SR and MR conditions were similar, those in the MR condition were more likely to be similar to the configurations of the principal component analysis biplots drawn from the ratings of valence and arousal for food image samples. In conclusion, this study provides robust empirical evidence that the MR condition can perform better in capturing sample differences in food-evoked emotions, while the SR condition is also effective in characterizing emotional profiles of test samples. Our findings will provide practical insights to sensory professionals, enabling them to effectively leverage the CEQ or its variants when measuring food-evoked emotions.
Experimental Correction and Treatment of Chronic Liver Failure Using Implantable Cell-Engineering Constructs of the Auxiliary Liver Based on a Bioactive Heterogeneous Biopolymer Hydrogel
Authors: Shagidulin Murat , Onishchenko Nina , Sevastianov Victor , Krasheninnikov Mikhail , Lyundup Aleksey , Nikolskaya Alla , Kryzhanovskaya Alena , Voznesenskaia Sofia , Gorelova Mariia , Perova Nadezhda , Kozlov Igor , Venediktov Artem , Piavchenko Gennadii , Gautier Sergey
Published: June 2023

Our study sought approaches for chronic liver failure (CLF) treatment and correction via cell-engineered constructs (CECs). They are built from biopolymer-based, microstructured, and collagen-containing hydrogel (BMCG). We also strove to evaluate the functional activity of BMCG in liver regeneration. Materials and Methods: Allogeneic liver cells (namely, hepatocytes; LC) together with mesenchymal multipotent stem cells of bone marrow origin (MMSC BM; BMSCs) were adhered to our BMCG to compose implanted liver CECs. Thereafter, we investigated a model of CLF in rats receiving the implanted CECs. The CLF had been provoked by long-term exposure to carbon tetrachloride. The study comprised male Wistar rats (n = 120) randomized into 3 groups: Group 1 was a control group with the saline treatment of the hepatic parenchyma (n = 40); Group 2 received BMCG only (n = 40); and Group 3 was loaded with CECs implanted into the parenchyma of their livers (n = 40). August rats (n = 30) made up a donor population for LCs and MMSC BM to develop grafts for animals from Group 3. The study length was 90 days. Results: CECs were shown to affect both biochemical test values and morphological parameters in rats with CLF. Conclusion: We found BMCG-derived CECs to be operational and active, with regenerative potential. Group 3 showed significant evidence of forced liver regeneration that tended to persist until the end of the study (day 90). The phenomenon is reflected by biochemical signs of hepatic functional recovery by day 30 after grafting (compared to Groups 1 and 2), whereas structural features of liver repair (necrosis prevention, missing formation of vacuoles, degenerating LC number decrease, and delay of hepatic fibrotic transformation). Such implantation of BMCG-derived CECs with allogeneic LCs and MMSC BM might represent a proper option to correct and treat CLF, as well as to maintain affected liver function in patients with liver grafting needed.
Primary PCI and Mental Health: A 12-Month Follow-Up Study
Authors: Vulcănescu Dragoș , Gheorman Veronica , Pîrvu Daniel Cristian , Dinescu Venera Cristina , Gheorman Victor , Udriștoiu Ion , Paraschiv Alina Maria , Bunescu Marius Gabriel , Berceanu Mihaela Corina , Gheorman Lavinia , Dinescu Sorin Nicolae , Popa Romeo , Florescu Cristina , Mită Adrian , Forțofoiu Cătălin Mircea
Published: June 2023

The research article highlights the significance of acute myocardial infarction (AMI) and its impact on depression and anxiety among patients’ post-primary percutaneous coronary interventions (PCI). The study aims to determine the frequency of depression and anxiety occurrence in patients with acute myocardial infarction after primary PCI. The objective of this study is to investigate the frequency of depression and anxiety in patients with acute myocardial infarction after primary PCI. The method used in the study involved the collection of data from 88 patients with acute myocardial infarction who underwent primary PCI treatment. The patients were tested before PCI and then at intervals of 1 month, 6 months, and 12 months post-PCI using the Hamilton Depression Scale (HAM-D17) and the Hamilton Anxiety Scale (HAM-A) to identify depression and anxiety symptoms, respectively. The study performed a comprehensive analysis of the collected data to determine the frequency of depression and anxiety occurrence in post-PCI patients. The study found evidence that primary PCI reduces depression and anxiety in patients who have experienced a myocardial infarction. However, mental health issues continue to be a significant psychological concern for patients post-PCI, impacting their lifestyle, self-care, and treatment adherence. The study suggests that healthcare providers should actively screen and manage psychiatric disorders in patients who have suffered from AMI as they are at an increased risk of mental disorders. In conclusion, the study indicates that depression and anxiety are common issues in acute myocardial infarction survivors, and interventions addressing these conditions should be a routine part of care. The study highlights the need for healthcare providers to be aware of the increased risk of mental disorders in individuals who have suffered from AMI. Understanding the impact of anxiety and depression on post-PCI patients is essential for the development of effective interventions that support patients’ recovery.
‘Apart from the Experiences of Subjects There Is Nothing, Nothing, Nothing, Bare Nothingness’—Nature and Subjectivity in Alfred North Whitehead
Authors: Schlehaider Isabella
Published: June 2023

While long ignored, the philosophy of Alfred North Whitehead has attracted considerable interest and wide academic reception since the 2000s. One reason for the renewed interest in Whitehead’s work is most certainly that his philosophy and concepts offer a way out of dualistic schemes of thought that have dominated the conceptual framework of the West since modernity. In my paper, I focus on Whitehead’s undoing of the opposition between nature and subjectivity, for it is a crucial aspect of Whitehead’s concept of nature not to exclude subjectivity from the ‘realm of nature’. For Whitehead, subjectivity is a fundamental feature of the whole of reality and by no means exclusively human, leading to a radically non-anthropocentric, pluralistic notion of the subject.
Effect of Low-Light Stress on Sugar and Acid Accumulation during Fruit Development and Ripening of Sweet Cherry
Authors: Tang Wenjing , Chen Chaoqun , Zhang Yao , Chu Yuanqi , Yang Wenlong , Cui Yiling , Kou Guanqiong , Chen Hongxu , Song Haiyan , Gong Ronggao
Published: June 2023

In the production process of sweet cherry, there are unreasonable planting densities and tree shape selections. With increasing tree age, the crown of the tree continues to expand and the tree body is prone to canopy closure, which leads to the inability to efficiently use space and light energy. Low-light has become a major limiting factor in the quality of sweet cherry. Therefore, we analyzed the changes of various physiological indicators and the transcriptome of ‘Hongdeng’ sweet cherry under shading treatment in this study to investigate the effects of low-light stress on the photosynthetic characteristics of sweet cherry leaves and fruit physiology and biochemistry. The results showed that shading significantly reduces the light capture capacity of leaves, damages the photosystem, reduces carbon assimilation capacity, and consumes the majority of the captured light energy as photochemical energy, thereby restricting the growth and development of leaves and reducing the accumulation of nutrients in fruits. Shading significantly reduced fruit weight, sugar content, and vitamin C content at maturity and significantly increased acid content. Transcriptomic data demonstrated that low-light stress produces a large number of differential genes related to carbon metabolism, organic acid metabolism, and stress resistance, thereby suggesting that low-light stress may affect the expression of these related genes and inclusions in the fruit. The results of this study will provide theoretical and technical support for the physiological response mechanism of low-light tolerance in sweet cherry, the selection and breeding of low-light tolerant sweet cherry varieties, and the cultivation of sweet cherry in facilities.
Comparison of Pollen-Collecting Abilities between Apis mellifera L. and Bombus terrestris L. in the Oil Tree Peony Field
Authors: Bao Junyi , Zhang Kaiyue , He Xiangnan , Chen Zhanfeng , Wang Junying , He Chunling , Hou Xiaogai
Published: June 2023

The lack of pollinators in the oil tree peony field was a serious problem for the seed yield. In the preliminary studies, we found that the seed rate of oil tree peonies was significantly improved by supplementing bees during the flowering stages in the pollination net room. In addition, the performance of Apis mellifera L. was better than Bombus terrestris L. To understand the interaction relationship between flowering characteristics and the managed bees, and the pollen-collecting ability of different species of bees, the flowering traits and the pollen loaded on bees were measured in this study. We found that the bees visited flowers with preference and they prefer to forage the flowers having pollen with higher viability. The B. terrestris carried more pollen (27,000.00 ± 5613.70 grains) on the body surface than that of the A. mellifera (7690.00 ± 2873.26 grains). The A. mellifera outperformed B. terrestris both in pollen deposition per visit on the stigma and on the pollen transfer efficiency. The viability of pollen on the body surface (67.77% ± 19.06%) and hind legs (92.02% ± 10.74%) of A. mellifera were both significantly higher than that of B. terrestris (31.84% ± 4.84% and 83.77% ± 6.40%). Our study indicated that the quantity and quality of pollen loaded on stigma by A. mellifera were both better than B. terrestris, which provided evidence that the A. mellifera was the effective pollinator pollinating for the oil tree peony in the pollination net room.
Intraoral Condylectomy with 3D-Printed Cutting Guide versus with Surgical Navigation: An Accuracy and Effectiveness Comparison
Authors: Si Jiawen , Zhang Chenglong , Tian Ming , Jiang Tengfei , Zhang Lei , Yu Hongbo , Shi Jun , Wang Xudong
Published: June 2023

This study compares the accuracy and effectiveness of our novel 3D-printed titanium cutting guides with intraoperative surgical navigation for performing intraoral condylectomy in patients with mandibular condylar osteochondroma (OC). A total of 21 patients with mandibular condylar OC underwent intraoral condylectomy with either 3D-printed cutting guides (cutting guide group) or with surgical navigation (navigation group). The condylectomy accuracy in the cutting guide group and navigation group was determined by analyzing the three-dimensional (3D) discrepancies between the postoperative computed tomography (CT) images and the preoperative virtual surgical plan (VSP). Moreover, the improvement of the mandibular symmetry in both groups was determined by evaluating the chin deviation, chin rotation and mandibular asymmetry index (AI). The superimposition of the condylar osteotomy area showed that the postoperative results were very close to the VSP in both groups. The mean 3D deviation and maximum 3D deviation between the planned condylectomy and the actual result were 1.20 ± 0.60 mm and 2.36 ± 0.51 mm in the cutting guide group, and 1.33 ± 0.76 mm and 4.27 ± 1.99 mm in the navigation group. Moreover, the facial symmetry was greatly improved in both groups, indicated by significantly decreased chin deviation, chin rotation and AI. In conclusion, our results show that both 3D-printed cutting-guide-assisted and surgical-navigation-assisted methods of intraoral condylectomy have high accuracy and efficiency, while using a cutting guide can generate a relatively higher surgical accuracy. Moreover, our cutting guides exhibit user-friendly features and simplicity, which represents a promising prospect in everyday clinical practice.
A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status
Authors: Ion Razvan-Marius , Sibianu Melania , Hutanu Adina , Beresescu Felicia Gabriela , Sala Daniela Tatiana , Flavius Mocian , Rosca Ancuta , Constantin Calin , Scurtu Alexandra , Moriczi Renata , Muresan Mircea Gabriel , Gabriel Popescu , Niculescu Raluca , Neagoe Radu Mircea
Published: June 2023

At present, obesity, as a part of metabolic syndrome, represents the leading factor for disability, and is correlated with higher inflammation status, morbidity, and mortality. The purpose of our study is to add new insights to the present body of knowledge regarding the correlations between chronic systemic inflammation and severe obesity, which cannot be treated without considering other metabolic syndrome conditions. Biomarkers of high-level chronic inflammation are recognized as important predictors of pro-inflammatory disease. Besides the well-known pro-inflammatory cytokines, such as WBCs (white blood cells), IL-1 (interleukin-1), IL-6 (interleukin-6), TNF-alpha (tumor necrosis factor-alpha), and hsCRP (high-sensitivity C-reactive protein), as well as anti-inflammatory markers, such as adiponectin and systemic inflammation, can be determined by a variety of blood tests as a largely available and inexpensive inflammatory biomarker tool. A few parameters, such as the neutrophil-to-lymphocyte ratio; the level of cholesterol 25-hydroxylase, which is part of the macrophage-enriched metabolic network in adipose tissue; or levels of glutamine, an immune–metabolic regulator in white adipose tissue, are markers that link obesity to inflammation. Through this narrative review, we try to emphasize the influence of the weight-loss process in reducing obesity-related pro-inflammatory status and associated comorbidities. All data from the presented studies report positive results following weight-loss procedures while improving overall health, an effect that lasts over time, as far as the existing research data show.
Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19
Authors: Mulet Alba , Núñez-Gil Iván J. , Carbonell Juan Antonio , Soriano Joan B. , Viana-Llamas María C. , Raposeiras-Roubin Sergio , Romero Rodolfo , Alfonso-Rodríguez Emilio , Uribarri Aitor , Feltes Gisela , Becerra-Muñoz Victor M. , Santoro Francesco , Pepe Martino , Castro-Mejía Alex F. , Chipayo David , Corbi-Pascual Miguel , López-Pais Javier , Vedia Oscar , Manzone Edoardo , Molina-Romera Germán , Espejo-Paeres Carolina , López-Masjuan Álvaro , Velicki Lazar , Fernández-Ortiz Antonio , El-Battrawy Ibrahim , Signes-Costa Jaime ,   on behalf of HOPE Team
Published: June 2023

Background: Concern has risen about the effects of COVID-19 in interstitial lung disease (ILD) patients. The aim of our study was to determine clinical characteristics and prognostic factors of ILD patients admitted for COVID-19. Methods: Ancillary analysis of an international, multicenter COVID-19 registry (HOPE: Health Outcome Predictive Evaluation) was performed. The subgroup of ILD patients was selected and compared with the rest of the cohort. Results: A total of 114 patients with ILDs were evaluated. Mean ± SD age was 72.4 ± 13.6 years, and 65.8% were men. ILD patients were older, had more comorbidities, received more home oxygen therapy and more frequently had respiratory failure upon admission than non-ILD patients (all p < 0.05). In laboratory findings, ILD patients more frequently had elevated LDH, C-reactive protein, and D-dimer levels (all p < 0.05). A multivariate analysis showed that chronic kidney disease and respiratory insufficiency on admission were predictors of ventilatory support, and that older age, kidney disease and elevated LDH were predictors of death. Conclusions: Our data show that ILD patients admitted for COVID-19 are older, have more comorbidities, more frequently require ventilatory support and have higher mortality than those without ILDs. Older age, kidney disease and LDH were independent predictors of mortality in this population.
Effects of Antithrombin on Persistent Inflammation, Immunosuppression, and Catabolism Syndrome among Patients with Sepsis-Induced Disseminated Intravascular Coagulation
Authors: Kanda Naoki , Ohbe Hiroyuki , Nakamura Kensuke
Published: June 2023

Persistent inflammation, immunosuppression, and catabolism syndrome (PICS) is a serious condition after critical care. We examined the efficacy of antithrombin, which may attenuate coagulopathy with the control of inflammation, for PICS among patients with sepsis-induced disseminated intravascular coagulation (DIC). The present study used the inpatient claims database with laboratory findings to identify patients admitted to intensive care units and diagnosed with sepsis and DIC. A composite of the incidence of PICS on day 14 or 14-day mortality as the primary outcome was compared between the antithrombin and control groups using a propensity-score-matched analysis. Secondary outcomes were the incidence of PICS on day 28, 28-day mortality, and in-hospital mortality. A total of 324 well-balanced matched pairs were generated from 1622 patients. The primary outcome did not differ between the antithrombin and control groups (63.9% vs. 68.2%, respectively, p = 0.245). However, the incidences of 28-day and in-hospital mortality were significantly lower in the antithrombin group (16.0% vs. 23.5% and 24.4% vs. 35.8%, respectively). Similar results were obtained in a sensitivity analysis using overlap weighting. Antithrombin did not reduce the occurrence of PICS on day 14 in patients with sepsis-induced DIC; however, it was associated with a better mid-term (day 28) prognosis.
Real-World Efficacy and Safety of Thoracic Radiotherapy after First-Line Chemo-Immunotherapy in Extensive-Stage Small-Cell Lung Cancer
Authors: Xie Zhaoliang , Liu Jingru , Wu Min , Wang Xiaohan , Lu Yuhan , Han Chunyan , Cong Lei , Li Jisheng , Meng Xue
Published: June 2023

(1) Background: At present, the efficacy and safety of thoracic radiotherapy (TRT) after chemo-immunotherapy (CT-IT) in patients with extensive-stage small-cell lung cancer (ES-SCLC) still remain unclear. The purpose of this study was to evaluate the role of TRT after CT-IT in patients with ES-SCLC. (2) Methods: From January 2020 to October 2021, patients with ES-SCLC treated with first-line anti-PD-L1 antibody plus platinum-etoposide chemotherapy were enrolled retrospectively. The survival data and adverse events data of patients treated with or without TRT after CT-IT were collected for analysis. (3) Results: A total of 118 patients with ES-SCLC treated with first-line CT-IT were retrospectively enrolled, with 45 patients with TRT and 73 patients without TRT after CT-IT. The median PFS and OS in the CT-IT + TRT group and CT-IT only group were 8.0 months versus 5.9 months (HR = 0.64, p = 0.025) and 22.7 months versus 14.7 months (HR = 0.52, p = 0.015), respectively. The median PFS and OS in all 118 patients treated with first-line CT-IT were 7.2 and 19.8 months with an ORR of 72.0%. In multivariate analyses, liver metastasis and response to CT-IT were shown to be independent prognostic factors of PFS (p < 0.05), while liver metastasis and bone metastasis were independent predictive factors of OS (p < 0.05). Although TRT was significantly associated with better PFS and OS in univariate analysis, the association of TRT and OS failed to reach statistical significance (HR = 0.564, p = 0.052) in multivariate analysis. There was no significant difference in adverse events (AEs) between two treatment groups (p = 0.58). (4) Conclusions: ES-SCLC patients treated with TRT after first-line CT-IT had prolonged PFS and OS with an acceptable safety profile. Further prospective randomized studies are necessary to explore the efficacy and safety of this treatment modality for ES-SCLC in future.
Infection Control among Healthcare Workers and Management of a Scabies Outbreak in a Large Italian University Hospital
Authors: Sponselli Stefania , De Maria Luigi , Caputi Antonio , Stefanizzi Pasquale , Bianchi Francesco Paolo , Delvecchio Giuseppe , Foti Caterina , Romita Paolo , Ambrogio Francesca , Zagaria Silvia , Giannelli Gianmarco , Tafuri Silvio , Vimercati Luigi
Published: June 2023

This retrospective observational study describes the results of an ad-hoc designated prevention protocol aimed at containing the spread of the scabies infestation among healthcare workers (HCWs) of a large University Hospital in Italy. The outbreak started on October 2022 and a preventive protocol was set up thanks to a multidisciplinary approach. HCWs at high scabies risk were defined as subjects working in Operative Units with a scabies prevalence higher than 2%, close contacts of a confirmed case of scabies, or HCWs with signs and symptoms of the disease. All cases at high scabies risk underwent a dermatological examination, and the infested HCWs were suspended from work until definitive healing. Mass drug administration was established for all HCWs working in Operative Units with a scabies prevalence higher than 2%. Until March 2023, out of 183 screening dermatological examinations, 21 (11.5%) were diagnostic for scabies. Between 11 October 2022 (date of the first diagnosed scabies case) and 6 March 2023 (the end of incubation period related to the last case detected), the frequency of scabies was 0.35% (21 scabies cases/6000 HCWs). The duration of the outbreak in our hospital was 14.7 weeks. Statistical analysis shows a significant association between scabies and being a nurse and having an allergy to dust mites. We obtained a low frequency of scabies infection, limiting the duration of the outbreak and the related economic burden.
Microbe-Plant Interactions Targeting Metal Stress: New Dimensions for Bioremediation Applications
Authors: Saharan Baljeet Singh , Chaudhary Twinkle , Mandal Balwan Singh , Kumar Dharmender , Kumar Ravinder , Sadh Pardeep Kumar , Duhan Joginder Singh
Published: June 2023

In the age of industrialization, numerous non-biodegradable pollutants like plastics, HMs, polychlorinated biphenyls, and various agrochemicals are a serious concern. These harmful toxic compounds pose a serious threat to food security because they enter the food chain through agricultural land and water. Physical and chemical techniques are used to remove HMs from contaminated soil. Microbial-metal interaction, a novel but underutilized strategy, might be used to lessen the stress caused by metals on plants. For reclaiming areas with high levels of heavy metal contamination, bioremediation is effective and environmentally friendly. In this study, the mechanism of action of endophytic bacteria that promote plant growth and survival in polluted soils—known as heavy metal-tolerant plant growth-promoting (HMT-PGP) microorganisms—and their function in the control of plant metal stress are examined. Numerous bacterial species, such as Arthrobacter, Bacillus, Burkholderia, Pseudomonas, and Stenotrophomonas, as well as a few fungi, such as Mucor, Talaromyces, Trichoderma, and Archaea, such as Natrialba and Haloferax, have also been identified as potent bioresources for biological clean-up. In this study, we additionally emphasize the role of plant growth-promoting bacteria (PGPB) in supporting the economical and environmentally friendly bioremediation of heavy hazardous metals. This study also emphasizes future potential and constraints, integrated metabolomics approaches, and the use of nanoparticles in microbial bioremediation for HMs.
Current Surgical Techniques in the Treatment of Adult Developmental Dysplasia of the Hip
Authors: Dhaliwal Anand S. , Akhtar Muzammil , Razick Daniel I. , Afzali Arya , Wilson Ethan , Nedopil Alexander J.
Published: June 2023

The surgical protocols currently used for the treatment of developmental dysplasia of the hip (DDH) are varied, with sufficient differences in clinical outcomes that warrant a review of the role of practicing orthopedic surgeons. This paper aims to summarize the current novel techniques within the realm of surgical treatment for adult DDH, thus serving as a guide to surgeons looking to quickly familiarize themselves with available techniques. We performed computer systematic literature searches of the Embase and PubMed databases from 2010 to 2 April 2022. Study parameters as well as their respective patient reported outcomes (PROMs) were described in detail and compiled into diagrams. Two novel techniques were identified for the treatment of borderline or low-grade DDH. Six techniques which included modifications to the Bernese periacetabular osteotomy (PAO) were identified for the treatment of symptomatic DDH. Three techniques which include combinations of arthroscopy and osteotomy were identified for the treatment of DDH with concomitant hip pathologies such as cam deformities. Finally, six techniques, all of which are modifications to total hip arthroplasty (THA), were identified for the treatment of high-grade DDH. The techniques detailed in this review therefore equip surgeons with the necessary knowledge to improve outcomes in patients with varying degrees of DDH.
Shear Wave Dispersion in Chronic Liver Disease: From Physical Principles to Clinical Usefulness
Authors: Garcovich Matteo , Paratore Mattia , Ainora Maria Elena , Riccardi Laura , Pompili Maurizio , Gasbarrini Antonio , Zocco Maria Assunta
Published: June 2023

The development of new applications in ultrasound (US) imaging in recent years has strengthened the role of this imaging technique in the management of different pathologies, particularly in the setting of liver disease. Improved B-mode imaging (3D and 4D), contrast-enhanced US (CEUS) and especially US-based elastography techniques have created the concept of multiparametric ultrasound (MP-US), a term borrowed from radiological sectional imaging. Among the new elastography techniques, shear wave dispersion is a newly developed imaging technology which enables the assessment of the shear waves’ dispersion slope. The analysis of the dispersion qualities of shear waves might be indirectly related to the tissue viscosity, thus providing biomechanical information concerning the pathologic state of the liver such as necroinflammation. Some of the most recent US devices have been embedded with software that evaluate the dispersion of shear waves/liver viscosity. In this review, the feasibility and the clinical applications of liver viscosity are reviewed based on the preliminary findings of both animal and human studies.
Environmental Footprint Neutrality Using Methods and Tools for Natural Capital Accounting in Life Cycle Assessment
Authors: Rugani Benedetto , Osset Philippe , Blanc Olivier , Benetto Enrico
Published: June 2023

Natural Capital Accounting (NCA) is becoming a reference tool for an increasing number of organizations transitioning towards environmental impact neutrality. However, one NCA technique applicable to all types of actors (individual, community, company, etc.) is missing because of the lack of consensus on how to quantify both their environmental impacts and dependencies on ecosystems. A coupled systematic and non-systematic review of the grey and scientific literature is performed here to (i) make an extensive review of state-of-the-art NCA methods, identifying their current utilization and limitations, and (ii) discern prospects about the challenges of integrating an Ecosystem Service Accounting in Life Cycle Assessment (ESA-LCA). While NCA methods can extensively evaluate the supply of ES, they tend to disregard the quantification of environmental impacts that imply a demand for ES. The ESA-LCA approach is identified as a robust solution to balance supply and demand of ecosystem services in NCA, allowing private and public actors to quantify their distance from impact neutrality targets. A novel definition of NC(A) in LCA is also formulated to support these future efforts, promoting a Mitigation Hierarchy-based strategy to avoid, minimize, restore, and offset impacts, and outlining a roadmap for practitioners to apply ESA-LCA across multiple economic sectors.
Spatial Distribution and Associated Risk Assessment of Heavy Metal Pollution in Farmland Soil Surrounding the Ganhe Industrial Park in Qinghai Province, China
Authors: Yin Fang , Meng Wenrui , Liu Lei , Feng Kai , Yin Cuijing
Published: June 2023

The farmland around the industrial areas in the Upper Yellow River is crucial for agricultural production but is vulnerable to contamination from the surrounding industries. This research focused on analyzing the spatial distribution and environmental risks of heavy metal pollution in the farmland around the Ganhe Industrial Park in the Qinghai–Tibet Plateau. A total of 138 surface soil samples were collected, and the concentration of seven heavy metals (Cd, As, Pb, Cr, Cu, Ni, and Zn) was analyzed using the random forest (RF) model. Pollution indicators, including the pollution index and Nemero index, were used to evaluate the pollution levels of soil heavy metals. The human health and ecological risks were estimated using the hazard index (HI) and the potential ecological risk index (RI). Cd and Zn were identified as the primary soil pollutants in the study area, with Cd being more concentrated than other heavy metals. Heavy metal contamination was most severe in the central–eastern region of the study area, with a ring-shaped distribution, which correlated with the presence of zinc smelting and chemical plants. Furthermore, the study revealed that soil heavy metal contamination posed a health threat to the local population, with children being particularly vulnerable to non-carcinogenic risks when the HI was 1.21 and to potential carcinogenic risks when the CR was 2.27 × 10−5. Additionally, heavy metal pollution caused a moderate to high ecological risk in 56.4% of the samples. The results highlighted the severe impact of soil heavy metal pollution on the delicate ecosystem of the Upper Yellow River and Qinghai–Tibet Plateau. The government should take action to improve soil environment management and prevent heavy metal pollution to protect the health of the local population and the ecological environment.
Construction of Ecological Corridors in Karst Areas Based on Ecological Sensitivity and Ecological Service Value
Authors: Liang Yi-Xuan , Wu Da-Fang , Wu Zhao-Jun , Xu Yue , Zhu Zi-Wen , Zhang Yu-Cheng , Zhu Hong
Published: June 2023

Ecological corridors play a key role in promoting the flow of ecological processes, guaranteeing ecological function services and maintaining biodiversity. Based on ecological sensitivity and ecological service values, ecological corridors in typical karst areas of Ningyuan County were constructed to lay the foundation for ecological environmental protection and land development and utilization in the county. Based on the current land use situation in 2020, the ecological source sites were identified by the combined results of ecological sensitivity evaluation and ecosystem service value analysis, and then potential corridors were generated based on the minimum cumulative resistance model (MCR) and the minimum cost path method, and key corridors were identified by the gravity model. The results show that (1) the areas exhibiting strong sensitivity are concentrated within regions characterized by better ecological environment quality; the ecosystem service value and ecological sensitivity have a similar distribution pattern, and those with high ecological value are mainly distributed in areas with better habitat quality such as woodlands and along water systems. (2) The total area of ecological source land in Ningyuan County is 879.14 km², accounting for 35.15% of the county area, mainly distributed in the south and north of the county. (3) There are nine ecological corridors in Ningyuan County, which are radially distributed in a spider-web manner, five important ecological corridors and four general ecological corridors, with total lengths of 96 km and 120.87 km, respectively.
Quantitative Analysis of Spatial Heterogeneity and Driving Forces of the Urban Spatial Structure’s Development Level Based on Multi-Source Big Data: A Case Study of Beijing, China
Authors: Liu Zhaoyu , Wang Yushuang , Zhang Chunxiao , Liu Dongya
Published: June 2023

Many developed cities in the world put forward a spatial development strategy in their construction planning. Analyzing the development level of the urban spatial structure and the influence of driving factors has become a hot topic. Based on 709,232 points of interest data in Beijing, China, this paper integrates nighttime light data and population density data to select eight key driving factors from three perspectives: urban function configuration, economic activity intensity and population spatial distribution. Geodetector is used to optimize data discreteness and highlight the spatial heterogeneity of the development level. We use the technique for order of preference by similarity to ideal solution (TOPSIS) model improved with the entropy weight method to grade the spatial differentiation characteristics of the comprehensive development level. The driving factors and their effects on space are further discussed using Geodetector. The results are as follows: (1) The quartile method can achieve the optimal dispersion of all urban functions. The standard deviation can achieve the optimal dispersion of economic activity intensity and population spatial distribution; (2) A comparison with the “Beijing Urban Master Plan (2016–2035)”, finds that the optimized evaluation system can effectively reflect the spatial heterogeneity of urban spatial structure development. It verifies the rationality of the evaluation methods and factors; (3) The driving force of the population under single-factor driving is 0.8428. The dual-factor driving force with population participation ranges from 0.8992 to 0.9550. The results of the study are significant and reflect the prominent role of population on the development level of spatial structure in Beijing. This paper aims to provide a new idea for the study of the interior space planning of large inland cities.