bluuebunny/crossref_metadata_2025 huggingface dataset:
Transradial approach to treat superficial femoral artery in‐stent restenosis
Authors: Trani Carlo , Burzotta Francesco , Tommasino Antonella , Giammarinaro Maura
Published: April 2009

Background:

Transradial access reduces the incidence of access site complications of percutaneous revascularization procedures. However, in patients with peripheral vascular disease, the adoption of transradial approach for superficial femoral artery (SFA) angioplasty is usually prevented by the distance between the vascular access and the target lesions; thus, SFA angioplasty is commonly performed by transfemoral approach. Recently, low‐profile balloons with extended shaft length became available, allowing to potentially address SFA lesions by transradial approach. As plain balloon angioplasty represents a valuable option for SFA in‐stent restenosis treatment, we evaluated the feasibility of transradial approach in this clinical setting.

Methods:

Transradial balloon angioplasty of SFA diffuse in‐stent restenosis was attempted in 12 patients aged 69.4 ± 5.1 years. Six‐French 125 cm long MP guiding catheters, 300 cm long 0.018″ guidewire, and low‐profile 4 Fr compatible 180 cm long shaft balloons (5 and 6 mm in diameter and 80–150 mm in length) were used.

Results:

The procedural success was 100%, and no complications occurred during the hospital stay. Compared with a matched group of patients in whom angioplasty was performed by trans‐femoral approach, main procedural key data resulted similar except for the amount of administered contrast dye, which was slightly but significantly lower in transradial group (170 ± 59 ml vs. 241 ± 103, P = 0.03).

Conclusions:

In conclusion, with the currently available equipment, the transradial approach is feasible and represents a valuable alternative for treatment of patients with SFA in‐stent restenosis. © 2009 Wiley‐Liss, Inc.
Clinical evaluation of the new Amplatzer duct occluder II for patent arterial duct occlusion
Authors: Bhole V. , Miller P. , Mehta C. , Stumper O. , Reinhardt Z. , De Giovanni J.V.
Published: April 2009

Background: Several devices such as coils and Amplatzer duct occluder (ADO) are used for catheter closure of patent arterial ducts (PDA). These carry a high success rate but residual shunts, suboptimal device orientation, and technical problems are encountered. The Amplatzer duct occluder II (ADO II) is designed to address these limitations. Objectives: To evaluate the technical features of the new ADO II device for PDA closure and document the immediate/early closure rate, complications and device behavior during implantation. Methods: Prospective, two center study from February 2008 to January 2009. Twenty‐seven patients (18 females) received the ADO II. The median age was 22 months (range: 7 months–68 years) and the median weight was 11.7 kg (range: 6.9–108). The median PDA diameter was 2.6 mm (range: 1–4.4). The approach was arterial in 13 and venous in 14 patients. Follow‐up included echocardiography at 1 day and 1 month postimplantation. Results: All implantations were technically successful with immediate complete angiographic closure in 21 and trivial contrast flow in six patients. The median procedure time was 43 min (range: 15–82) and the fluoroscopy time was 6 min (range: 2.2–26.5). Echocardiography confirmed no residual shunts on the following day. There were no complications. Conclusion: The new ADO II is a versatile and very effective device for closure of PDAs of various shapes, lengths, and up to diameters of 5.5 mm. The disc articulations, high early closure rate, arterial or venous approach options, and small diameter delivery catheter are all beneficial features. © 2009 Wiley‐Liss, Inc.
Percutaneous mitral annuloplasty device leaves free access to cardiac veins for resynchronization therapy
Authors: Hoppe Uta C. , Brandt Mathias C. , Degen Hubertus , Dodos Fotini , Schneider Thorsten , Stoepel Carsten , Kroener Axel , Haude Michael
Published: April 2009

Objectives:

To assess the feasibility to place a left ventricular lead into the coronary sinus following percutaneous mitral annuloplasty.

Background:

Percutaneous coronary sinus‐based mitral annuloplasty may reduce functional mitral regurgitation in chronic systolic heart failure. However, concerns have been raised whether the placement of an annular remodeling device in the coronary sinus might preclude subsequent lead placement for resynchronization therapy (CRT).

Methods:

Three patients with ischemic cardiomyopathy included in the AMADEUS™ trial underwent CRT 7 to 8 months after implantation of a mitral valve annuloplasty device.

Results:

Fluoroscopy and control coronary angiography revealed a stable position of the annuloplasty device without any compromise of coronary blood flow. Intravascular ultrasound of the coronary sinus excluded any thrombus formation and demonstrated smooth endothelialization of the annular remodeling device. Access of the coronary sinus and placement of the left ventricular lead into a posterolateral cardiac vein was not at all compromised by the mitral valve annuloplasty device in any patient.

Conclusions:

Positioning a left ventricular pacing lead for CRT is feasible after permanent implantation of a coronary sinus‐based mitral annuloplasty device in patients with dilated cardiomyopathy. © 2009 Wiley‐Liss, Inc.
Transradial coronary intervention using a novel 5‐Fr sheathless guiding catheter
Authors: Takeshita Satoshi , Saito Shigeru
Published: April 2009

We have recently developed a 5‐Fr sheathless guiding catheter system (Virtual 3‐Fr, Medikit, Japan), composed of a hydrophilic catheter and a central dilator. This combination of catheter and dilator enables us to introduce the catheter into the artery without the need of an introducer sheath. Because the outer diameter of this 5‐Fr sheathless guiding catheter system is approximately 2‐Fr sizes smaller than a conventional guiding catheter system, this system provides us with less invasive angioplasty and a puncture site injury equivalent to a conventional 3‐Fr introducer sheath. To demonstrate the potential of this 5‐Fr sheathless guiding system, we report two cases of chronic total occlusion successfully treated by the transradial approach. This novel 5‐Fr sheathless system may become a viable alternative to conventional guiding catheters, and provide a favorable impact upon vascular access complications and patient morbidity. © 2009 Wiley‐Liss, Inc.
Percutaneous closure of left atrial appendage to prevent embolic events in high‐risk patients with chronic atrial fibrillation
Authors: Ussia Gian Paolo , Mulè Massimiliano , Cammalleri Valeria , Scarabelli Marilena , Barbanti Marco , Immè Sebastiano , Mangiafico Sarah , Marchese Anna , Galassi Alfredo Ruggero , Tamburino Corrado
Published: April 2009

Background:

Percutaneous closure of the left atrial appendage (LAA) is a novel alternative for the treatment of patients with atrial fibrillation (AF) and with a high risk of stroke who are not eligible for long‐term anticoagulation therapy. The aim of this study was to asses the safety, feasibility, and long‐term efficacy of this procedure.

Methods:

From July 2004 to June 2007, 20 patients (13 male, mean age 69 ± 8 years) with non–valvular AF (NV‐AF) underwent LAA percutaneous closure using the PLAATO™ system, implanted through a transeptal access. All patients had contraindications to anticoagulant therapy and were at high risk for cardioembolic stroke (mean CHADS2 score 3 ± 1.2). A trans‐thoracic echocardiogram was performed at 1, 3, and every 6 months after the procedure, whereas a trans‐oesophageal echocardiogram (TOE) was scheduled at 6 months. After 24 months, a phone interview was obtained.

Results:

All procedures were successfully performed in 18 patients. In two patients, LAA closure was not feasible for the presence of a multilobed LAA. Two patients underwent percutaneous closure of patent foramen ovale in the same session. In one patient, the procedure was complicated by cardiac perforation with pericardial effusion, treated with pericardiocentesis. At a mean follow up of 40 ± 10 months, no embolic events occurred. One patient died, after 36 months, for gastric cancer. TOE examination showed the complete exclusion of the LAA in all patients.

Conclusions:

Percutaneous closure of LAA is safe and efficacious to prevent stroke in patients with NV‐AF at high risk for cardioembolic events, with contraindications to anticoagulant therapy. © 2009 Wiley‐Liss, Inc.
Defining the length of stay following percutaneous coronary intervention
Authors: Chambers Charles E. , Dehmer Gregory J. , Cox David A. , Harrington Robert A. , Babb Joseph D. , Popma Jeffrey J. , Turco Mark A. , Weiner Bonnie H. , Tommaso Carl L.
Published: April 2009

Percutaneous coronary intervention (PCI) is the most common method of coronary revascularization. Over time, as operator skills and technical advances have improved procedural outcomes, the length of stay (LOS) has decreased. However, standardization in the definition of LOS following PCI has been challenging due to significant physician, procedural, and patient variables. Given the increased focus on both patient safety as well as the cost of medical care, system process issues are a concern and provide a driving force for standardization while simultaneously maintaining the quality of patient care. This document: (1) provides a summary of the existing published data on same‐day patient discharge following PCI, (2) reviews studies that developed methods to predict risk following PCI, and (3) provides clarification of the terms used to define care settings following PCI. In addition, a decision matrix is proposed for the care of patients following PCI. It is intended to provide both the interventional cardiologist as well as the facilities, in which they are associated, a guide to allow for the appropriate LOS for the appropriate patient who could be considered for early discharge or outpatient intervention. © 2009 Wiley‐Liss, Inc.
Experimental and Theoretical Investigation of Droplet Dispersion in Venturi Scrubbers with Axial Liquid Injection
Authors: Talaie M. R. , Mokhtarian N. , Talaei A. , Karimikhosroabadi M. , Sadeghi F.
Published: April 2009

Droplet dispersion in a Venturi scrubber with axial liquid injection was investigated both experimentally and theoretically. The main objective of this study was to develop a mathematical model to predict droplet dispersion in a Venturi scrubber with axial liquid injection. The effects of the Peclet number and droplet size distribution on droplet dispersion were studied using the developed model. Sampling of the droplets was carried out, isokinetically, in 16 positions at the end of the throat section. The experimental data were used to find the parameters of the developed model, such as the Peclet number. From the results of this study, it was found that the Peclet number was not constant across the cross section of the scrubber channel. In order to achieve a better agreement between the results of the model and the experimental data, it was required to consider Peclet number variations across the Venturi channel. It was also revealed that the parameter representing the width of the Rosin‐Rammler distribution of droplet size could not be considered constant and it was influenced significantly by the operating parameters such as liquid flow rate and gas velocity.
Scale‐up of Mini‐Plant Extractors on Energy Dissipation‐Based Population Balances
Authors: Steinmetz T. , Bart H.‐J.
Published: April 2009

The new scale‐up concept for extraction columns relies on three identities being kept idem, as is the total specific flow rate, energy dissipation, and mean droplet residence time in a compartment. The droplet population balance‐based model allows maintaining hydrodynamic similarity in different geometries, as is in a mini‐ or a pilot plant. This leads to similar breakage and coalescence probabilities giving comparable droplet size distributions, thus mass transfer area and extraction efficiency. A new breakage frequency term has been developed relying on the energy dissipation rate and is thus independent from geometric constraints. The traditional scale‐up rules are based either on a constant tip velocity (≈ N) or on a constant energy input (≈ N3), whereas here it follows a constant energy dissipation (≈ N2). A step‐by‐step approach to the new procedure proved by case samples is given. Data from literature pilot experiments could be verified by computer simulations, without using adaptable parameters. All parameters in the correlations where derived in a lab‐scale apparatus and the coalescence parameters were obtained in the mini‐plant experiments. Derivation between simulated and experimental pilot data for stage numbers was less than 14 %, operating parameters (rotational speed N, throughput) were underestimated by 4 % leading to a slightly smaller HETS (Height Equivalent of Transfer Stages) value as measured, affecting the column height with less than 1 %.
On the Role of Water in Dielectric Heating with Radio Waves
Authors: Roland U. , Kopinke F.‐D.
Published: April 2009

Beside the classical mechanism of orientation polarization which is sufficient to explain dielectric heating of aqueous liquids, a number of additional aspects have to be considered when humid solids are heated by microwaves or radio waves. The large relative dielectric constant of water can lead to shielding and, therefore, attenuation of the electrical field in humid matrices. The shielding effect is influenced by the geometric arrangement of compartments with varying humidity. On the other hand, the large dielectric loss of water results in an effective heating. As shown by modeling of appropriate experiments, the dielectric loss factor is significantly changed for water which is in intimate contact with surfaces. The dielectric loss factor is much larger for water in the surface layers compared with the bulk phase. For some solids dielectric heating is based on a completely different mechanism which is also influenced by water. The dominant mechanism leading to dielectric heating of zeolites is the migration of cations within the zeolite framework. Water has a strong effect on the dielectric loss factor, most likely by hydration or modifying the electrostatic interactions of cations with the lattice.
Scalable Numerical Tools for Flow and Pressure Drop Computation in Fibrous Filter Media
Authors: Strauß F. , Hoferer J. , Heuveline V. , Kasper G.
Published: April 2009

The prediction of flow behavior and pressure drop in fibrous filter media is challenging due to the complexity of the nonuniform fiber structure. Numerical calculation tools can considerably contribute to pressure drop determination for inhomogeneous filter structures. A numerical solution approach based on the finite element method to simulate 2D and 3D filter structures is considered. As numerical examples, computer designed homogeneous and inhomogeneous 2D cases where the numerical approach is validated by analytical models are investigated. Furthermore, the capability of the numerical method to simulate real 3D structures corresponding to more than 25 million degrees of freedom of the related algebraic system is demonstrated. The large systems involved require the use of dedicated techniques related to high performance computing.
Synthesis and Optical Properties of 2‐(Benzo[b]thiophene‐3‐yl)pyrroles and a New BODIPY Fluorophore (BODIPY=4,4‐Difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene)
Authors: Schmidt Elena Yu. , Trofimov Boris A. , Mikhaleva Al'bina I. , Zorina Nadezhda V. , Protzuk Nadezhda I. , Petrushenko Konstantin B. , Ushakov Igor A. , Dvorko Marina Yu. , Méallet‐Renault Rachel , Clavier Gilles , Vu Thanh Truc , Tran Ha Thanh Thao , Pansu Robert B.
Published: April 2009

The light fantastic: Two new 2‐(benzo[b]thiophene‐3‐yl)pyrroles have been synthesized, and are shown to exhibit optical properties that are promising for optoelectronic materials and devices such as highly efficient fluorescent sensors (see scheme). In addition a new BODIPY fluorophore, derived from 2‐(benzo[b]thiophene‐3‐yl)pyrrole, was also isolated and shows good spectroscopic properties in solution which are fully preserved in the solid state.

magnified image

2‐(Benzo[b]thiophene‐3‐yl)‐1‐vinylpyrrole has been synthesized directly from 3‐acetylbenzo[b]thiophene oxime and acetylene (flow system, KOH‐DMSO, 120 °C, 5 h) in 68 % yield. Devinylation of the synthesized pyrrole (Hg(OAc)2, NaBH4, 50 °C) led to the corresponding 2‐(benzo[b]thiophene‐3‐yl)pyrrole in 63 % yield. Trifluoroacetylation of both the pyrroles with trifluoroacetic anhydride (80 °C, 1 h) gave the corresponding 5‐trifluoroacetyl pyrroles in 97 % and 76 % yields, respectively. 2‐(Benzo[b]thiophene‐3‐yl)pyrrole was reacted subsequently with mesityl aldehyde, 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ), and BF3⋅OEt2 to afford 4,4‐difluoro‐3,5‐di(benzo[b]thiophene‐3‐yl)‐8‐mesityl‐4‐bora‐3a,4a‐diaza‐s‐indacene, a representative of the novel BODIPY fluorophore family (BODIPY=4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene), in 34 % overall yield. The synthesized pyrroles exhibit promising optical properties (absorption and emission spectra, nonlinear optical (NLO) features), superior to existing analogues. The BODIPY fluorophore displays an intense red‐shifted fluorescence emission in CH2Cl2 (625 nm, 0.84 fluorescence quantum yield) that is fully preserved in the solid state.
Synthesis and Properties of (Triptycenedicarboxylatio)zinc Coordination Networks
Authors: Vagin Sergei I. , Ott Anna K. , Hoffmann Stephan D. , Lanzinger Dominic , Rieger Bernhard
Published: April 2009

Paddle wheels and pillars: Layered 3D metal–organic frameworks comprised of paddle‐wheel coordination units are constructed under a variety of conditions to incorporate bridging ligands (as illustrated) that impart desired properties, such as guest‐exchange behavior, luminescence, microporosity, and stability, to the material.

magnified image

(Triptycenedicarboxylato)zinc metal–organic frameworks (MOFs) based on paddle wheel secondary building units (SBUs) with different axial ligands have been prepared. The reproducible formation of the layered paddle‐wheel structures from triptycenedicarboxylic acid (H2TDC) and zinc nitrate under various conditions seems to be characteristic of this acid and is utilized for the construction of 3D frameworks by a pillaring approach. We attempted to bring additional functionalities into MOFs by employing the appropriate pillaring ligands, for example, bis(4‐pyridyl)‐s‐tetrazine and bis(4‐pyridyl)‐dimethoxy‐p‐phenylenedivinylene, and investigated certain properties of some MOF materials, such as guest‐exchange behavior, luminescence, microporosity, and stability.
Encapsulation and Sustained Release of Curcumin using Superparamagnetic Silica Reservoirs
Authors: Chin Suk Fun , Iyer K. Swaminathan , Saunders Martin , St. Pierre Tim G. , Buckley Craig , Paskevicius Mark , Raston Colin L.
Published: April 2009

For controlled release and targeted delivery of curcumin in an aqueous medium a method of encapsulating curcumin and magnetic nanoparticles inside porous silica matrix has been developed. Curcumin and superparamagnetic nanoparticles are loaded inside porous silica in a single process. The graphic shows the TEM image of microtomed sample of Fe3O4 particles surrounded by a silica matrix.

magnified image
Adaptation and Optical Signal Generation in a Constitutional Dynamic Network
Authors: Ulrich Sébastien , Lehn Jean‐Marie
Published: April 2009

Self‐sorting dynamic library: The effector‐induced modulation of the shape and constitution of the members of a constitutional dynamic network (see scheme) allows for the regulation of the interconnected constituents and for the control of an emergent function, here the generation of an optical output which originates from a charge‐transfer interaction.

magnified image
Palladium(0)‐Catalyzed Cross‐Coupling of Potassium (Z)‐2‐Chloroalk‐1‐enyl Trifluoroborates: A Chemo‐ and Stereoselective Access to (Z)‐Chloroolefins and Trisubstituted Alkenes
Authors: Guinchard Xavier , Bugaut Xavier , Cook Cyril , Roulland Emmanuel
Published: April 2009

Original and ambivalent: We describe the preparation of a series of new potassium trifluoroborates1, and the study of their behaviour in a Pd0‐catalyzed cross‐coupling reaction. We found that compounds1are endowed with original properties as they behave as nucleophilic cross‐coupling partners chemoselectively, but also as ambivalent synthons. The usefulness of this methodology has been successfully illustrated by the first total synthesis of anN‐acyl spermidine.

magnified image

We describe the preparation of a series of new potassium trifluoroborates1and the study of their behaviour in a Pd0‐catalyzed cross‐coupling reaction. We found that compounds1are endowed with original properties as they behave as nucleophilic cross‐coupling partners chemoselectively but also as ambivalent synthons. The usefulness of this methodology has been successfully illustrated by the first total synthesis of anN‐acyl spermidine.
ChemInform Abstract: Temperature‐Induced A—B Intersite Charge Transfer in an A‐Site‐Ordered LaCu3Fe4O12 Perovskite.
Authors: Long Y. W. , Hayashi N. , Saito T. , Azuma M. , Muranaka S. , Shimakawa Y.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ferroelectric and Incipient Ferroelectric Properties of a Novel Sr9‐xPbxCe2Ti2O36 (x = 0—9) Ceramic System.
Authors: Kamba Stanislav , et al. et al.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iridium and Ruthenium Complexes with Chelating N‐Heterocyclic Carbenes: Efficient Catalysts for Transfer Hydrogenation, β‐Alkylation of Alcohols, and N‐Alkylation of Amines.
Authors: Gnanamgari Dinakar , Sauer Effiette L. O. , Schley Nathan D. , Butler Chase , Incarvito Christopher D. , Crabtree Robert H.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Amine—Polyoxometalate Hybrids as Recoverable Asymmetric Enamine Catalysts under Neat and Aqueous Conditions.
Authors: Li Jiuyuan , Hu Shenshen , Luo Sanzhong , Cheng Jin‐Pei
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aqua‐aminoorganoboron Catalyst: Engineering Single Water Molecule to Act as an Acid Catalyst in Nitro Aldol Reaction.
Authors: Yoshimoto Junichi , Sandoval Christian A. , Saito Susumu
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: o‐Benzenedisulfonimide as a Reusable Broensted Acid Catalyst for Ritter‐Type Reactions.
Authors: Barbero Margherita , Bazzi Stefano , Cadamuro Silvano , Dughera Stefano
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conversion of Allylic Alcohols to Stereodefined Trisubstituted Alkenes: A Complementary Process to the Claisen Rearrangement.
Authors: Belardi Justin K. , Micalizio Glenn C.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Preparation of Cyclopropylmagnesium Reagents via a Br—Mg Exchange Using i‐PrMgCl·LiCl in the Presence of Dioxane.
Authors: Rauhut Christian B. , Cervino Christian , Krasovskiy Arkady , Knochel Paul
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed γ‐Selective and Stereospecific Allyl—Aryl Coupling Between Allylic Acetates and Arylboronic Acids.
Authors: Ohmiya Hirohisa , Makida Yusuke , Tanaka Tatsunori , Sawamura Masaya
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of N‐Alkyl 1,3‐Diamino‐4,6‐diamidobenzenes.
Authors: Seillan Claire , Siri Olivier
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cu(OTf)2/NEt3‐Promoted Cyclocondensation of Activated α‐Methylene Alkenes and Nitroolefins: A Novel One‐Pot Synthesis of Polysubstituted Benzenes.
Authors: Su Weike , Ding Kai , Chen Zhiwei
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Alkylimidazole as Amphiphilic Organocatalyst: “Catalytic” Morita—Baylis—Hillman Reaction on Water Without Organic Solvent.
Authors: Asano Keisuke , Matsubara Seijiro
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: SN2′ Boron‐Mediated Mitsunobu Reactions — A New One‐Pot Three‐Component Synthesis of Substituted Enamides and Enol Benzoates.
Authors: Berree Fabienne , Gernigon Nicolas , Hercouet Alain , Lin Chia Hui , Carboni Bertrand
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heck Reaction Catalyzed by Mesoporous SBA‐15‐Supported Ionic Liquid—Pd(OAc)2.
Authors: Jung Ji‐Young , Taher Abu , Kim Hyun‐Jin , Ahn Wha‐Seung , Jin Myung‐Jong
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Benzylic and Allylic Alkylation of Protic Nucleophiles with Sulfonamides Through Double Lewis Acid Catalyzed Cleavage of sp3 Carbon—Nitrogen Bonds.
Authors: Liu Cong‐Rong , Li Man‐Bo , Yang Cui‐Feng , Tian Shi‐Kai
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Indene Derivatives via Electrophilic Cyclization.
Authors: Khan Zulfiqar Ali , Wirth Thomas
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3,5‐Dibromo‐1‐(1,1‐dioxothietanyl‐3)‐1,2,4‐triazole, New Reagent for Preparation of Substituted Thietane 1,1‐Dioxides.
Authors: Klen E. E. , Khaliullin F. A. , Makarova N. N.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bifunctional Phosphine‐Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis‐2,3‐Dihydrobenzofurans from Salicyl N‐Thiophosphinyl Imines and Allenes.
Authors: Meng Xiangtai , Huang You , Chen Ruyu
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis and Spectral Properties of Novel Porphyrazines with Eight (p‐Tolylmethylthio) and (o‐Tolylmethylthio) Units.
Authors: Cenan Neslihan , Gonca Erguen
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthetic Route to 3‐Sulfenyl‐ and 3‐Selenylindoles by n‐Bu4NI‐Induced Electrophilic Cyclization.
Authors: Chen Yu , Cho Chul‐Hee , Larock Richard C.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Component One‐Pot Synthetic Route to 2‐Amino‐5‐alkylidene‐thiazol‐4‐ones.
Authors: Anderluh Marko , Jukic Marko , Petric Rok
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclic Ketimines as Superior Electrophiles for NHC‐Catalyzed Homoenolate Additions with Broad Scope and Low Catalyst Loadings.
Authors: Rommel Michael , Fukuzumi Takeo , Bode Jeffrey W.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Hetero Analogues of Isoflavones. Part 25. Synthesis of 2‐Alkyl‐3‐(2‐benzimidazolyl)chromones.
Authors: Frasinyuk M. S. , Khilya V. P.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative Alkylation of Cyclic Benzyl Ethers with Malonates and Ketones Using Oxygen as the Terminal Oxidant.
Authors: Yoo Woo‐Jin , Correia Camille A. , Zhang Yuhua , Li Chao‐Jun
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Hydrophosphinylation of Alkenes with Diphenylphosphine Oxide.
Authors: Kawaguchi Shin‐ichi , Nomoto Akihiro , Sonoda Motohiro , Ogawa Akiya
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Medicinal Flowers. Part 24. Chemical Structures and Hepatoprotective Effects of Constituents from Flowers of Hedychium coronarium.
Authors: Nakamura Seikou , Okazaki Yoshie , Ninomiya Kiyofumi , Morikawa Toshio , Matsuda Hisashi , Yoshikawa Masayuki
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies on Novel Bioactive Phytochemicals. Part 66. Multifidone (I): A Novel Cytotoxic Lathyrane‐Type Diterpene Having an Unusual Six‐Membered A Ring Jatropha multifida.
Authors: Das Biswanath , Reddy Kongara Ravinder , Ravikanth Bommena , Raju Tuniki Venugopal , Sridhar Balasubramanian , Khan Patan Usman , Rao Janapala Venkateswara
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Concise Synthesis of (‐)‐Indolizidines 209D and 209B.
Authors: Wu Hao , Yu Menglong , Zhang Yazhu , Zhao Gang
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electric‐Field Control of Magnetism in Complex Oxide Thin Films
Authors: Spaldin Nicola A. , Ramesh R.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cross‐Coupling Reaction of Oxazoles
Authors: Inoue Munenori
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Eight‐Membered and Larger Rings
Authors: Newkome George R.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Five‐Membered Ring Systems with O and S (Se, Te) Atoms
Authors: Aitken R. Alan , Power Lynn A.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Five‐Membered Ring Systems with More than One N Atom
Authors: Yet Larry
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Research on the Dioxotetraamine Macrocyclic Compounds
Authors: Shang Xue‐Fang , Lin Hua‐Kuan
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Six‐Membered Ring Systems: Pyridines and Benzo Derivatives
Authors: Fraser Heidi L. , Floyd M. Brawner , Hopper Darrin W.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Chiral Fluorinated Materials via Biotransformation
Authors: Kitazume Tomoya , Matsuda Tomoko , Nakamura Kaoru
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Approaches to gem‐Difluoromethylene Compounds
Authors: Reddy V. Prakash , Perambuduru Meher , Alleti Ramesh
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Chemistry of Interhalogen Monofluorides
Authors: Shellhamer Dale F. , Heasley Victor L.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low‐Molecular‐Weight Inhibitors of NF‐ϰB Signalling Pathways
Authors: Dolinnaya N. G. , Kubareva E. A. , Kazanova E. V. , Zigangirova N. A. , Naroditsky B. S. , Gintsburg A. L. , Oretskaya T. S.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pharmacological and Therapeutic Secrets of Plant and Brain (Endo)Cannabinoids
Authors: Hanus Lumir Ondrej
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Synthesis Within Continuous Flow Microreactors
Authors: Watts Paul
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ex Uno Plures (“Out of One, Many”): New Paradigms for Expanding the Range of Polyolefins Through Reversible Group Transfers.
Authors: Sita Lawrence R.
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nuclear Magnetic Resonance Spectroscopy in Ionic Liquids
Authors: Giernoth Ralf
Published: April 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The geometry and motion of nematode sperm cells
Authors: Demekhin Evgeny , Haugen Nicole , Ibanez Brian , Lederman Jerome , Murphy Kaitlyn , Verzi Diana , Witczak Debra
Published: April 2009

The nematode sperm cell crawls by recycling major sperm protein (MSP) from dimers into subfilaments, filaments, and filament complexes, as a result of thermal writhing in the presence of hydrophobic patches. Polymerization near leading edges of the cell intercolates MSP dimers onto the tips of growing filament complexes, forcing them against the cell boundary, and extending the cytoskeleton in the direction of motion. Strong adhesive forces attach the cell to the substrate in the forward part of the lamellipod, while depolymerization in the rearward part of the cell breaks down the cytoskeleton, contracting the lamellipod and pulling the cell body forward. The movement of these cells, then, is caused by coordinated protrusive, adhesive and contractile forces, spatially separated across the lamellipod. This paper considers a phenomenological model that tracks discrete elements of the cytoskeleton in curvilinear coordinates. The pseudo‐two dimensional model primarily considers protrusion and rotation of the cell, along with the evolution of the cell boundary. General assumptions are that pH levels within the lamellipod regulate protrusion, contraction and adhesion, and that growth of the cytoskeleton, over time, is perpendicular to the evolving cell boundary. The model follows the growth and contraction of a discrete number of MSP fiber complexes, since they appear to be the principle contributors for force generation in cell boundary protrusion and contraction, and the backbone for the dynamic geometry and motion. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress
Authors: Kozikowski Alan P. , Chen Yihua , Subhasish Tapadar , Lewin Nancy E. , Blumberg Peter M. , Zhong Zhenyu , D'Annibale Melissa A. , Wang Weng‐Long , Shen Yong , Langley Brett
Published: April 2009

A series of benzolactam compounds were synthesized, some of which caused a concentration‐dependent increase in sAPPα and decrease in Aβ production in the concentration range of 0.1–10 μM. Moreover, some compounds showed neuroprotective effects in the 10–20 μM range in the HCA cortical neuron model of oxidative stress and no toxicity in measurements of neuron viability by MTT assay, even at the highest concentrations tested (20 μM).

magnified image

Alzheimer's disease (AD) is a well‐studied neurodegenerative process characterized by the presence of amyloid plaques and neurofibrillary tangles. In this study, a series of protein kinase C (PKC) activators were investigated, some of which also exhibit histone deacetylase (HDAC) inhibitory activity, under the hypothesis that such compounds might provide a new path forward in the discovery of drugs for the treatment of AD. The PKC‐activating properties of these drugs were expected to enhance the α‐secretase pathway in the processing of amyloid precursor protein (APP), while their HDAC inhibition was anticipated to confer neuroprotective activity. We found that benzolactams 9 and 11–14 caused a concentration‐dependent increase in sAPPα and decrease in β‐amyloid (Aβ) production in the concentration range of 0.1–10 μM, consistent with a shift of APP metabolism toward the α‐secretase‐processing pathway. Moreover, compounds 9–14 showed neuroprotective effects in the 10–20 μM range in the homocysteate (HCA) cortical neuron model of oxidative stress. In parallel, we found that the most neuroprotective compounds caused increased levels of histone acetylation (H4), thus indicating their likely ability to inhibit HDAC activity. As the majority of the compounds studied also show nanomolar binding affinities for PKC, we conclude that it is possible to design, de novo, agents that combine both PKC‐activating properties along with HDAC inhibitory properties. Such agents would be capable of modulating amyloid processing while showing neuroprotection. These findings may offer a new approach to therapies that exhibit disease‐modifying effects, as opposed to symptomatic relief, in the treatment of AD.