Features of hemostasis in patients after severe Covid-19 at discharge from the hospital (original study)
Authors:   FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia, Romanov A. O. , Arkhangelskaya A. N. ,   FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia, Sharipova M. M. ,   FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia, Gurevich K. G. ,   FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia; Research Institute for Healthcare Organization and Medical Management of the Moscow Healthcare Department, Popova I. A. ,   I. M. Sechenov First Moscow State Medical University, Мoscow, Russia, Shantyr I. I. ,   FSBI All-russian center of emergency and radiation medicine named after a.m. Nikiforov of the Ministry of Emergency Situations of Russia, Saint Petersburg, Yakovleva M. V. ,   FSBI All-russian center of emergency and radiation medicine named after a.m. Nikiforov of the Ministry of Emergency Situations of Russia, Saint Petersburg, Vlasenko M. A. ,   FSBI All-russian center of emergency and radiation medicine named after a.m. Nikiforov of the Ministry of Emergency Situations of Russia, Saint Petersburg, Levchenko O. V. ,   FSBEI HE A. I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation, Moscow, Russia
Published: April 2023

Since 2020, the world has been living in the COVID-19 pandemic caused by the SARS-CoV-2 virus. This situation is due to the high virulence and prevalence of the virus, which has reached epidemic proportions in recent years. Hemostasis disorders are the main marker and prognosis of the severe course of the disease. The virus in the body of a patient with COVID-19 triggers a pathophysiological chain reaction, which, in turn, will lead to the development of a cytokine storm, a disorder in the hemostasis system, and the development of multiple organ disorders. The purpose of the study: to determine and study the influence of various factors on the characteristics of hemostasis in patients with moderate and severe COVID-19. The object of the study were patients with moderate and severe forms of the disease. The following methods were used in the study: standard laboratory diagnostics and hair mineralogram. Results. Moderate and severe courses have clear laboratory markers, with a high probability of developing thrombotic complications, especially in conditions of deficiency of such minerals as zinc, selenium, iron, copper, bismuth, and aluminum, which have immunoregulatory, antioxidant, antiviral, and hemostatic properties, as well as reduce the risk of secondary infection. Conclusions. The results of the study suggest the importance of using minerals and emphasize the significance of using minerals in patients at the very beginning of the disease in order to strengthen the main physiological systems in case of laboratory-confirmed deficiency.