bluuebunny/crossref_metadata_2025 huggingface dataset:
Person-Situation Debate Revisited: Phase Transitions with Quenched and Annealed Disorders
Authors: Jędrzejewski Arkadiusz , Sznajd-Weron Katarzyna
Published: August 2017

We study the q-voter model driven by stochastic noise arising from one out of two types of nonconformity: anticonformity or independence. We compare two approaches that were inspired by the famous psychological controversy known as the person–situation debate. We relate the person approach with the quenched disorder and the situation approach with the annealed disorder, and investigate how these two approaches influence order–disorder phase transitions observed in the q-voter model with noise. We show that under a quenched disorder, differences between models with independence and anticonformity are weaker and only quantitative. In contrast, annealing has a much more profound impact on the system and leads to qualitative differences between models on a macroscopic level. Furthermore, only under an annealed disorder may the discontinuous phase transitions appear. It seems that freezing the agents’ behavior at the beginning of simulation—introducing quenched disorder—supports second-order phase transitions, whereas allowing agents to reverse their attitude in time—incorporating annealed disorder—supports discontinuous ones. We show that anticonformity is insensitive to the type of disorder, and in all cases it gives the same result. We precede our study with a short insight from statistical physics into annealed vs. quenched disorder and a brief review of these two approaches in models of opinion dynamics.
Bioenergy Potential and Utilization Costs for the Supply of Forest Woody Biomass for Energetic Use at a Regional Scale in Mexico
Authors: Flores Hernández Ulises , Jaeger Dirk , Islas Samperio Jorge
Published: August 2017

While considering constraints in regard to sustainability, this paper reviews the development of a methodology to assess the introduction of bioenergy supply chains in Mexico based on forest woody biomass. Three research modules include analyses of forest biomass utilization residues that originated from: (1) harvesting activities, (2) non-extracted stands and (3) sawmills. A regional case study focusing on tree species of commercial importance (pine, oak and fir) in the 10 provinces with the highest timber production located in the north and central-south part of the country, is analyzed. After applying the methodology, the theoretical potential of available woody biomass for energetic use amounts to 6,357,482 m3. When applying the sustainability constraints, the technically feasible supply of forest woody biomass for energetic use sums up to 5,798,722 m3, which relate to a technical energy potential of 45.96 PJ for 2013. Moreover, a biomass energy flow chart showing energy values for each analyzed source and species is presented. Monte Carlo simulations were carried out for each cost involved in utilizing the resulting available woody biomass for energetic use. In the absence of national studies which include forest operations and bioenergy transformation to calculate the sustainable energy potential, the developed methodology adds innovation for assessing woody biomass availability.
Economic Dispatch with Demand Response in Smart Grid: Bargaining Model and Solutions
Authors: Ma Kai , Wang Congshan , Yang Jie , Yang Qiuxia , Yuan Yazhou
Published: August 2017

This paper proposes an economic dispatch strategy for the electricity system with one generation company, multiple utility companies and multiple consumers, which participate in demand response to keep the electricity real-time balance. In the wholesale markets, multiple utility companies will commonly select a reliable agent to negotiate with the generation company on the wholesale price. It is challengeable to find a wholesale price to run the electricity market fairly and effectively. In this study, we use the multiple utility companies’ profits to denote the utility function of the agent and formulate the interaction between the agent and the generation company as a bargaining problem, where the wholesale price was enforced in the bargaining outcome. Then, the Raiffa–Kalai–Smorodinsky bargaining solution (RBS) was utilized to achieve the fair and optimal outcome. In the retail markets, the unfavorable disturbances exist in the power management and price when the consumers participate in the demand response to keep the electricity real-time balance, which motivates us to further consider the dynamic power management algorithm with the additive disturbances, and then obtain the optimal power consumption and optimal retail price. Based on the consumers’ utility maximization, we establish a price regulation model with price feedback in the electricity retail markets, and then use the iterative algorithm to solve the optimal retail price and the consumer’s optimal power consumption. Hence, the input-to-state stability condition with additive electricity measurement disturbance and price disturbance is given. Numerical results demonstrate the effectiveness of the economic dispatch strategy.
Theoretical Study of the Effects of Spark Timing on the Performance and Emissions of a Light-Duty Spark Ignited Engine Running under Either Gasoline or Ethanol or Butanol Fuel Operating Modes
Authors: Papagiannakis Roussos , Rakopoulos Dimitrios , Rakopoulos Constantine
Published: August 2017

Much research is ongoing to find suitable alternate fuels in order to reduce the exhaust emission levels without deteriorating the basic performance characteristics of conventional spark-ignited (SI) engines. One of the methods to achieve the above problem is the use of alcohols as full supplement fuels to normal gasoline. At the same time, many related research studies have shown that the use of alcohols has a negative impact on some basic engine performance characteristics, e.g., brake power output, etc. On the other hand, spark timing is one of the critical engine operating parameters that significantly influences the combustion mechanism inside the combustion chamber of a SI engine. Therefore, the primary objective of the present work is to investigate the effect of spark timing on the performance and emissions characteristics of a conventional, four-stroke, SI engine running under three different fuel operating modes, viz. with conventional gasoline or ethanol or butanol. The specific investigation is conducted by using an in-house, comprehensive, two-zone phenomenological model. The predictive ability of the model is tested against pertinent experimental data and it is found that the computed results are in good agreement with the respective experimental ones. For all test cases examined herein, the results concern basic engine performance characteristics, i.e., cylinder pressure, power output, specific fuel consumption etc., as well as NO and CO emissions. The main objectives of the work were to record and evaluate the impact that spark timing has on the performance characteristics and emitted pollutants of a conventional SI engine, operating under either conventional gasoline or ethanol or butanol fuel operating modes. Moreover, it deals with the determination of an optimum combination between the type of fuel used and the spark timing, so that probable undesirable effects on engine performance characteristics would be avoided. By comparing this investigation results, it is revealed that the use of alcohols as a full substitute fuel of gasoline accompanied with an appropriate alteration of the spark timing, could be a promising solution to improving both the efficiency and environmental behavior of a light-duty, spark-ignited (SI) engine, without causing any harmful problems to the engine operational lifetime. The conclusions from the study may prove valuable for the application of this technological solution to existing conventional SI engines.
Sodium Chloride and Its Influence on the Aroma Profile of Yeasted Bread
Authors: Belz Markus , Axel Claudia , Beauchamp Jonathan , Zannini Emanuele , Arendt Elke , Czerny Michael
Published: August 2017

The impact of sodium chloride (NaCl) concentration on the yeast activity in bread dough and its influence on the aroma profile of the baked bread was investigated. Key aroma compounds in the bread samples were analysed by two-dimensional high-resolution gas chromatography-mass spectrometry in combination with solvent-assisted flavour evaporation distillation. High-sensitivity proton-transfer-reaction mass spectrometry was used to detect and quantify 2-phenylethanol in the headspace of the bread dough during fermentation. The analyses revealed significant (p < 0.05) changes in the aroma compounds 2-phenylethanol, (E)-2-nonenal, and 2,4-(E,E)-decadienal. Descriptive sensory analysis and discriminating triangle tests revealed that significant differences were only determinable in samples with different yeast levels but not samples with different NaCl concentrations. This indicates that a reduction in NaCl does not significantly influence the aroma profile of yeasted bread at levels above the odour thresholds of the relevant compounds, thus consumers in general cannot detect an altered odour profile of low‑salt bread crumb.
Controlling Blown Pack Spoilage Using Anti-Microbial Packaging
Authors: Reid Rachael , Bolton Declan , Tiuftin Andrey , Kerry Joe , Fanning Séamus , Whyte Paul
Published: August 2017

Active (anti-microbial) packaging was prepared using three different formulations; Auranta FV; Inbac-MDA and sodium octanoate at two concentrations (2.5 and 3.5 times their minimum inhibitory concentration (MIC, the lowest concentration that will inhibit the visible growth of the organisms) against Clostridium estertheticum, DSMZ 8809). Inoculated beef samples were packaged using the active packaging and monitored for 100 days storage at 2 °C for blown pack spoilage. The time to the onset of blown pack spoilage was significantly (p < 0.01) increased using Auranta FV and sodium octanoate (caprylic acid sodium salt) at both concentrations. Moreover, sodium octanoate packs had significantly (p < 0.01) delayed blown pack spoilage as compared to Auranta FV. It was therefore concluded that Auranta FV or sodium octanoate, incorporated into the packaging materials used for vacuum packaged beef, would inhibit blown pack spoilage and in the case of the latter, well beyond the 42 days storage period currently required for beef primals.
Spatial Variation Relationship between Floating Population and Residential Burglary: A Case Study from ZG, China
Authors: Chen Jianguo , Liu Lin , Zhou Suhong , Xiao Luzi , Jiang Chao
Published: August 2017

With the rapid development of China’s economy, the demand for labor in the coastal cities continues to grow. Due to restrictions imposed by China’s household registration system, a large number of floating populations have subsequently appeared. The relationship between floating populations and crime, however, is not well understood. This paper investigates the impact of a floating population on residential burglary on a fine spatial scale. The floating population was divided into the floating population from other provinces (FPFOP) and the floating population from the same province as ZG city (FPFSP), because of the high heterogeneity. Univariate spatial patterns in residential burglary and the floating population in ZG were explored using Moran’s I and LISA (local indicators of spatial association) models. Furthermore, a geographically weighted Poisson regression model, which addressed the spatial effects in the data, was employed to explore the relationship between the floating population and residential burglary. The results revealed that the impact of the floating population on residential burglary is complex. The floating population from the same province did not have a significant impact on residential burglary in most parts of the city, while the floating population from other provinces had a significantly positive impact on residential burglary in most of the study areas and the magnitude of this impact varied across the study area.
Artemisia Iwayomogi Extract Attenuates High-Fat Diet-Induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low Density Lipoprotein Assembly in the Liver
Authors: Lee Jinhui , Narayan Vikram , Hong Eun , Whang Wan , Park Taesun
Published: August 2017

This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance. These beneficial effects were accompanied by the activation of adiponectin-adenosine monophosphate-activated protein kinase (AMPK) mediated signaling cascades in the liver, which downregulated molecules involved in lipogenesis and concurrently upregulated molecules related to fatty acid oxidation. The downregulation of molecules involved in very low density lipoprotein assembly, which was associated with improved hepatic insulin signaling, also appeared to contribute to the AI-induced attenuation of hypertriglyceridemia.
Re-adaption on Earth after Spaceflights Affects the Mouse Liver Proteome
Authors: Anselm Viktoria , Novikova Svetlana , Zgoda Victor
Published: August 2017

Harsh environmental conditions including microgravity and radiation during prolonged spaceflights are known to alter hepatic metabolism. Our studies have focused on the analysis of possible changes in metabolic pathways in the livers of mice from spaceflight project “Bion-M 1”. Mice experienced 30 days of spaceflight with and without an additional re-adaption period of seven days compared to control mice on Earth. To investigate mice livers we have performed proteomic profiling utilizing shotgun mass spectrometry followed by label-free quantification. Proteomic data analysis provided 12,206 unique peptides and 1,086 identified proteins. Label-free quantification using MaxQuant software followed by multiple sample statistical testing (ANOVA) revealed 218 up-regulated and 224 down-regulated proteins in the post-flight compared to the other groups. Proteins related to amino acid metabolism showed higher levels after re-adaption, which may indicate higher rates of gluconeogenesis. Members of the peroxisome proliferator-activated receptor pathway reconstitute their level after seven days based on a decreased level in comparison with the flight group, which indicates diminished liver lipotoxicity. Moreover, bile acid secretion may regenerate on Earth due to reconstitution of related transmembrane proteins and CYP superfamily proteins elevated levels seven days after the spaceflight. Thus, our study demonstrates reconstitution of pharmacological response and decreased liver lipotoxicity within seven days, whereas glucose uptake should be monitored due to alterations in gluconeogenesis.
The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl− Channel
Authors: Marunaka Yoshinori
Published: August 2017

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel belongs to the ATP-binding cassette (ABC) transporter superfamily and regulates Cl− secretion in epithelial cells for water secretion. Loss-of-function mutations to the CFTR gene cause dehydrated mucus on the apical side of epithelial cells and increase the susceptibility of bacterial infection, especially in the airway and pulmonary tissues. Therefore, research on the molecular properties of CFTR, such as its gating mechanism and subcellular trafficking, have been intensively pursued. Dysregulated CFTR trafficking is one of the major pathological hallmarks in cystic fibrosis (CF) patients bearing missense mutations in the CFTR gene. Hormones that activate cAMP signaling, such as catecholamine, have been found to regulate the intracellular trafficking of CFTR. Insulin is one of the hormones that regulate cAMP production and promote trafficking of transmembrane proteins to the plasma membrane. The functional interactions between insulin and CFTR have not yet been clearly defined. In this review article, I review the roles of CFTR in epithelial cells, its regulatory role in insulin secretion, and a mechanism of CFTR regulation by insulin.
Cross-Linguistic Transfer of Object Clitic Structure: A Case of L3 Brazilian Portuguese
Authors: Parma Alan
Published: August 2017

This study examines the role of previously known language in L3 Brazilian Portuguese (BP) object expression acquisition. It investigates the claims of the main models of L3 transfer, the cumulative enhancement model (CEM) (Flynn et al. 2004), the L2 status factor (Bardel and Falk 2007) and the typological proximity model (TPM) (Rothman 2011) in both comprehension and production tasks. It also aims at measuring the extent of transfer effects in comprehension and production. Participants (N = 33) were divided into three groups, a mirror image group of L3 BP learners who already knew English and Spanish, and a native control group. They performed a self-paced reading task and a story telling task, which focused on object clitics in BP. Results indicate early convergence to the BP grammar by the L3 learners in what refers to object expression. They also suggest that, although no major effects of transfer were obtained, clitic placement errors in the production task and preference for inanimate and non-specific contexts for null objects can be traced to Spanish, independent of order of acquisition, providing evidence in favor of the TPM. Finally, comprehension seems to override the effects of language transfer earlier than production.
Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement
Authors: Kiminami Keishi , Konishi Toshiisa , Mizumoto Minori , Nagata Kohei , Honda Michiyo , Arimura Hidetoshi , Aizawa Mamoru
Published: August 2017

We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapatite (HAp) the surface of which has been modified with inositol hexaphosphate (IP6) by adding α-tricalcium phosphate (α-TCP) powder. In order to create a novel chelate-setting CPC with sufficient bioresorbability, gelatin particles were added into the IP6-HAp/α-TCP cement system to modify the material properties. The effects of adding polysaccharides (chitosan, chondroitin sulfate, and sodium alginate) into the sodium dihydrogen phosphate mixing solution on the material properties of the gelatin-hybridized CPC were evaluated. The results of mechanical testing revealed that chondroitin sulfate would be the most suitable for fabricating the hybridized CPC with higher compressive strength. Moreover, further addition of an appropriate amount of citric acid could improve the anti-washout capability of the cement paste. In summary, a gelatin-hybridized IP6-HAp/α-TCP cement system prepared with a mixing solution containing chondroitin sulfate and citric acid is expected to be a beneficial CPC, with sufficient bioresorbability and material properties.
Does Osmotic Stress Affect Natural Product Expression in Fungi?
Authors: Overy David , Correa Hebelin , Roullier Catherine , Chi Wei-Chiung , Pang Ka-Lai , Rateb Mostafa , Ebel Rainer , Shang Zhuo , Capon Rob , Bills Gerald , Kerr Russell
Published: August 2017

The discovery of new natural products from fungi isolated from the marine environment has increased dramatically over the last few decades, leading to the identification of over 1000 new metabolites. However, most of the reported marine-derived species appear to be terrestrial in origin yet at the same time, facultatively halo- or osmotolerant. An unanswered question regarding the apparent chemical productivity of marine-derived fungi is whether the common practice of fermenting strains in seawater contributes to enhanced secondary metabolism? To answer this question, a terrestrial isolate of Aspergillus aculeatus was fermented in osmotic and saline stress conditions in parallel across multiple sites. The ex-type strain of A. aculeatus was obtained from three different culture collections. Site-to-site variations in metabolite expression were observed, suggesting that subculturing of the same strain and subtle variations in experimental protocols can have pronounced effects upon metabolite expression. Replicated experiments at individual sites indicated that secondary metabolite production was divergent between osmotic and saline treatments. Titers of some metabolites increased or decreased in response to increasing osmolite (salt or glycerol) concentrations. Furthermore, in some cases, the expression of some secondary metabolites in relation to osmotic and saline stress was attributed to specific sources of the ex-type strains.
Surface Characterization and Corrosion Resistance of 36Cr-Ni-Mo4 Steel Coated by WC-Co Cermet Electrode Using Micro-Electro Welding
Authors: Azhideh Mohamad , Aghajani Hossein , Pourbagheri Hadi
Published: August 2017

In this paper the influence of spark energy on corrosion resistance, hardness, surface roughness and morphology of WC-Co coated 36Cr-Ni-Mo4 steel by Micro-Electro Welding (MEW) was investigated. Frequencies of 5, 8 and 11 kHz, currents of 15, 25 and 35 A and duty cycles of 10, 30 and 50 % were applied for coating of the samples using a WC-Co cermet electrode. The results indicate that increasing the current, Duty cycle and frequency of the process increases spark energy. As spark energy increases, efficiency of coating increases to 80% and then decreases. X-ray diffraction (XRD) analysis was used to identify the phases. The results indicated that other than the peaks obtained for the metallic Iron with BCC (Body Centered Cubic) structure, Tungsten Carbide, Cr7C3 and Titanium Carbide phases were also seen on the surface. Vickers micro hardness method was used for hardness measurement of the samples. Surface hardness increases to 817.33 HV0.05 with spark energy increasing up to 1.03 mJ, and then reducing. Optical Microscopy (OM) and scanning electron microscopy (SEM) to study Microstructural and atomic force microscopy (AFM) to study the topography, morphology and roughness were used. Polarization technique in 3.5 wt % NaCl solution was used to evaluate the corrosion properties. The results of the energy dispersive X-ray spectroscopy (EDS) analysis indicate that with increasing spark energy, the amount of Tungsten in surface increases to 41.95 wt % and then decreases. As spark energy increases up to 2.17 mJ, thickness of coating increases to 8.31 μm and then decreases. As spark energy increases, surface roughness is also increased. Corrosion test results indicated that the lowest corrosion rate (2.6 × 10−8 mpy) is related to the sample with the highest level of efficiency.
Systems Biology Approach to Bioremediation of Nitroaromatics: Constraint-Based Analysis of 2,4,6-Trinitrotoluene Biotransformation by Escherichia coli
Authors: Iman Maryam , Sobati Tabassom , Panahi Yunes , Mobasheri Meysam
Published: August 2017

Microbial remediation of nitroaromatic compounds (NACs) is a promising environmentally friendly and cost-effective approach to the removal of these life-threating agents. Escherichia coli (E. coli) has shown remarkable capability for the biotransformation of 2,4,6-trinitro-toluene (TNT). Efforts to develop E. coli as an efficient TNT degrading biocatalyst will benefit from holistic flux-level description of interactions between multiple TNT transforming pathways operating in the strain. To gain such an insight, we extended the genome-scale constraint-based model of E. coli to account for a curated version of major TNT transformation pathways known or evidently hypothesized to be active in E. coli in present of TNT. Using constraint-based analysis (CBA) methods, we then performed several series of in silico experiments to elucidate the contribution of these pathways individually or in combination to the E. coli TNT transformation capacity. Results of our analyses were validated by replicating several experimentally observed TNT degradation phenotypes in E. coli cultures. We further used the extended model to explore the influence of process parameters, including aeration regime, TNT concentration, cell density, and carbon source on TNT degradation efficiency. We also conducted an in silico metabolic engineering study to design a series of E. coli mutants capable of degrading TNT at higher yield compared with the wild-type strain. Our study, therefore, extends the application of CBA to bioremediation of nitroaromatics and demonstrates the usefulness of this approach to inform bioremediation research.
A Review of the Antiviral Role of Green Tea Catechins
Authors: Xu Jun , Xu Zhao , Zheng Wenming
Published: August 2017

Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses are responsible not only for acute infections but also many chronic infectious diseases. To prevent diseases caused by viruses, the discovery of effective antiviral drugs, in addition to vaccine development, is important. Green tea catechins (GTCs) are polyphenolic compounds from the leaves of Camellia sinensis. In recent decades, GTCs have been reported to provide various health benefits against numerous diseases. Studies have shown that GTCs, especially epigallocatechin-3-gallate (EGCG), have antiviral effects against diverse viruses. The aim of this review is to summarize the developments regarding the antiviral activities of GTCs, to discuss the mechanisms underlying these effects and to offer suggestions for future research directions and perspectives on the antiviral effects of EGCG.
Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds
Authors: Pedras M. , Abdoli Abbas , Sarma-Mamillapalle Vijay
Published: August 2017

The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines. Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors) that inhibit the detoxification of brassinin by L. maculans.
ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds
Authors: Li Lingjun , Li Qianqian , Ding Shengqiang , Xin Pengyang , Zhang Yuqin , Huang Shenlong , Zhang Guisheng
Published: August 2017

Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N3 was designed and synthesized for the first time. With ADP-ribosyl-N3 as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties.
Changes of Bone-Related Minerals during Denosumab Administration in Post-Menopausal Osteoporotic Patients
Authors: Suzuki Takako , Nakamura Yukio , Kato Hiroyuki
Published: August 2017

Objectives: This retrospective study included 21 patients with primary osteoporosis who were treated with the anti-resorption drug, denosumab. To date, there has been no detailed report on the changes of bone-related minerals after anti-resorption drug therapy. Methods: Twenty-one post-menopausal females were retrospectively enrolled. Serum zinc (Zn), magnesium (Mg), iron (Fe), copper (Cu), grip strength, and estimated glomerular filtration rate (eGFR) were examined at one week and 1, 2, 4, 6, 8, 10, and 12 months. Lumbar spine (L1-4) bone mineral density (L-BMD) and bilateral total hip BMD (H-BMD) were examined before and at 4, 8, and 12 months after treatment commencement. Results: Serum Zn tended to decrease at one week and one month, and tended to increase during 10 to 12 months. Serum Cu maintained during zero to eight months, then decreased at 10 and 12 months. Serum Fe gradually increased after four months. Serum Mg sharply increased at one week, then decreased further. Grip strength increased for two months, then slightly decreased and maintained 4 to 12 months. eGFR almost maintained for zero to eight months, then slightly decreased thereafter. L-BMD values significantly increased at eight (5.8%) (p < 0.01) and 12 months (9.8%) (p < 0.01). H-BMD increased during the period (at 12 months: 3.7%). Conclusions: These results suggest that at later phases of denosumab therapy, Zn and Fe tended to increase while Mg tended to decrease, all of which are important for bone metabolism. Thus, denosumab might improve Zn and Fe metabolism, and thereby likely increase BMD. Since denosumab may not improve Mg, it is better to obtain Mg supplementation during the therapy.
First Detection of Rotavirus Group C in Asymptomatic Pigs of Smallholder Farms in East Africa
Authors: Amimo Joshua Oluoch , Machuka Eunice Magoma , Okoth Edward
Published: August 2017

Abstract: Group C rotavirus (RVC) has been described to be a causative agent of gastroenteritis in humans and animals including pigs, cows, and dogs. Fecal samples collected from asymptomatic pigs in smallholder swine farms in Kenya and Uganda were screened for the presence of group C rotaviruses (RVC) using a reverse transcription-polymerase chain reaction assay. A total of 446 samples were tested and 37 were positive (8.3%). A significantly larger (p < 0.05) number of RVC-positive samples was detected in groups of older pigs (5–6 months) than in younger piglets (1–2 months). There were no significant differences in the RVC detection rate between the pigs that were full time housed/tethered and those that were free range combined with housing/tethering. After compiling these data with diagnostic results for group A rotaviruses (RVA), 13 RVC-positive samples were also positive for RVA. This study provides the first evidence that porcine group C rotavirus may be detected frequently in asymptomatic piglets (aged < 1–6 months) in East Africa. The occurrence of RVC in mixed infections with RVA and other enteric pathogens requires further research to investigate the pathogenic potential of RVC in pigs.
Integrating Soil Silicon Amendment into Management Programs for Insect Pests of Drill-Seeded Rice
Authors: Villegas James , Way Michael , Pearson Rebecca , Stout Michael
Published: August 2017

Silicon soil amendment has been shown to enhance plant defenses against insect pests. Rice is a silicon-accumulating graminaceous plant. In the southern United States, the rice water weevil and stem borers are important pests of rice. Current management tactics for these pests rely heavily on the use of insecticides. This study evaluated the effects of silicon amendment when combined with current management tactics for these rice insect pests in the field. Field experiments were conducted from 2013 to 2015. Rice was drill-planted in plots subjected to factorial combinations of variety (conventional and hybrid), chlorantraniliprole seed treatment (treated and untreated), and silicon amendment (treated and untreated). Silicon amendment reduced densities of weevil larvae on a single sampling date in 2014, but did not affect densities of whiteheads caused by stem borers. In contrast, insecticidal seed treatment strongly reduced densities of both weevil larvae and whiteheads. Higher densities of weevil larvae were also observed in the hybrid variety in 2014, while higher incidences of whiteheads were observed in the conventional variety in 2014 and 2015. Silicon amendment improved rice yields, as did chlorantraniliprole seed treatment and use of the hybrid variety.
Evaluating Sentinel-2 and Landsat-8 Data to Map Sucessional Forest Stages in a Subtropical Forest in Southern Brazil
Authors: Sothe Camile , Almeida Cláudia , Liesenberg Veraldo , Schimalski Marcos
Published: August 2017

Studies designed to discriminate different successional forest stages play a strategic role in forest management, forest policy and environmental conservation in tropical environments. The discrimination of different successional forest stages is still a challenge due to the spectral similarity among the concerned classes. Considering this, the objective of this paper was to investigate the performance of Sentinel-2 and Landsat-8 data for discriminating different successional forest stages of a patch located in a subtropical portion of the Atlantic Rain Forest in Southern Brazil with the aid of two machine learning algorithms and relying on the use of spectral reflectance data selected over two seasons and attributes thereof derived. Random Forest (RF) and Support Vector Machine (SVM) were used as classifiers with different subsets of predictor variables (multitemporal spectral reflectance, textural metrics and vegetation indices). All the experiments reached satisfactory results, with Kappa indices varying between 0.9, with Landsat-8 spectral reflectance alone and the SVM algorithm, and 0.98, with Sentinel-2 spectral reflectance alone also associated with the SVM algorithm. The Landsat-8 data had a significant increase in accuracy with the inclusion of other predictor variables in the classification process besides the pure spectral reflectance bands. The classification methods SVM and RF had similar performances in general. As to the RF method, the texture mean of the red-edge and SWIR bands were considered the most important ranked attributes for the classification of Sentinel-2 data, while attributes resulting from multitemporal bands, textural metrics of SWIR bands and vegetation indices were the most important ones in the Landsat-8 data classification.
Multiple Cracks Detection in Pipeline Using Damage Index Matrix Based on Piezoceramic Transducer-Enabled Stress Wave Propagation
Authors: Du Guofeng , Kong Qingzhao , Zhou Hua , Gu Haichang
Published: August 2017

Cracks in oil and gas pipelines cause leakage which results in property damage, environmental pollution, and even personal injury or loss of lives. In this paper, an active-sensing approach was conducted to identify the crack damage in pipeline structure using a stress wave propagation approach with piezoceramic transducers. A pipeline segment instrumented with five distributed piezoceramic transducers was used as the testing specimen in this research. Four cracks were artificially cut on the specimen, and each crack had six damage cases corresponding to different crack depths. In this way, cracks at different locations with different damage degrees were simulated. In each damage case, one piezoceramic transducer was used as an actuator to generate a stress wave to propagate along the pipeline specimen, and the other piezoceramic transducers were used as sensors to detect the wave responses. To quantitatively evaluate the crack damage status, a wavelet packet-based damage index matrix was developed. Experimental results show that the proposed method can evaluate the crack severity and estimate the crack location in the pipeline structure based on the proposed damage index matrix. The sensitivity of the proposed method decreases with increasing distance between the crack and the mounted piezoceramic transducers.
Real-Time Rain Rate Evaluation via Satellite Downlink Signal Attenuation Measurement
Authors: Giannetti Filippo , Reggiannini Ruggero , Moretti Marco , Adirosi Elisa , Baldini Luca , Facheris Luca , Antonini Andrea , Melani Samantha , Bacci Giacomo , Petrolino Antonio , Vaccaro Attilio
Published: August 2017

We present the NEFOCAST project (named by the contraction of “Nefele”, which is the Italian spelling for the mythological cloud nymph Nephele, and “forecast”), funded by the Tuscany Region, about the feasibility of a system for the detection and monitoring of precipitation fields over the regional territory based on the use of a widespread network of new-generation Eutelsat “SmartLNB” (smart low-noise block converter) domestic terminals. Though primarily intended for interactive satellite services, these devices can also be used as weather sensors, as they have the capability of measuring the rain-induced attenuation incurred by the downlink signal and relaying it on an auxiliary return channel. We illustrate the NEFOCAST system architecture, consisting of the network of ground sensor terminals, the space segment, and the service center, which has the task of processing the information relayed by the terminals for generating rain field maps. We discuss a few methods that allow the conversion of a rain attenuation measurement into an instantaneous rainfall rate. Specifically, we discuss an exponential model relating the specific rain attenuation to the rainfall rate, whose coefficients were obtained from extensive experimental data. The above model permits the inferring of the rainfall rate from the total signal attenuation provided by the SmartLNB and from the link geometry knowledge. Some preliminary results obtained from a SmartLNB installed in Pisa are presented and compared with the output of a conventional tipping bucket rain gauge. It is shown that the NEFOCAST sensor is able to track the fast-varying rainfall rate accurately with no delay, as opposed to a conventional gauge.
Signal-to-Noise Ratio Enhancement Based on Empirical Mode Decomposition in Phase-Sensitive Optical Time Domain Reflectometry Systems
Authors: Qin Zengguang , Chen Hui , Chang Jun
Published: August 2017

We propose a novel denoising method based on empirical mode decomposition (EMD) to improve the signal-to-noise ratio (SNR) for vibration sensing in phase-sensitive optical time domain reflectometry (φ-OTDR) systems. Raw Rayleigh backscattering traces are decomposed into a series of intrinsic mode functions (IMFs) and a residual component using an EMD algorithm. High frequency noise is eliminated by removing several IMFs at the position without vibration selected by the Pearson correlation coefficient (PCC). When the pulse width is 50 ns, the SNR of location information for the vibration events of 100 Hz and 1.2 kHz is increased to as high as 42.52 dB and 39.58 dB, respectively, with a 2 km sensing fiber, which demonstrates the excellent performance of this new method.
Efficacy of Carbohydrate Ingestion on CrossFit Exercise Performance
Authors: Rountree Jaden , Krings Ben , Peterson Timothy , Thigpen Adam , McAllister Matthew , Holmes Megan , Smith JohnEric
Published: August 2017

The efficacy of carbohydrate (CHO) ingestion during high-intensity strength and conditioning type exercise has yield mixed results. However, little is known about shorter duration high-intensity exercise such as CrossFit. The purpose of this study was to investigate the performance impact of CHO ingestion during high-intensity exercise sessions lasting approximately 30 min. Eight healthy males participated in a total of four trials; two familiarizations, a CHO trial, and a similarly flavored, non-caloric placebo (PLA) trial. CrossFit’s “Fight Gone Bad Five” (FGBF) workout of the day was the exercise model which incorporated five rounds of maximal repetition exercises, wall throw, box jump, sumo deadlift high pull, push press, and rowing, followed by one minute of rest. Total repetitions and calories expended were summated from each round to quantify total work (FGBF score). No difference was found for the total work between CHO (321 ± 51) or PLA (314 ± 52) trials (p = 0.38). There were also no main effects (p > 0.05) for treatment comparing exercise performance across rounds. Based on the findings of this study, it does not appear that ingestion of CHO during short duration, high-intensity CrossFit exercise will provide a beneficial performance effect.
Formalizing the Informal: Understanding the Position of Informal Settlements and Slums in Sustainable Urbanization Policies and Strategies in Bandung, Indonesia
Authors: Jones Paul
Published: August 2017

Sustainable urbanization policies and strategies are posited as a major tool by which to achieve the sustainable development of growing towns and cities. A major challenge for sustainable urbanization policies and strategies is how to address the complexity of urbanization, especially the ongoing growth of informal settlements and slums in developing countries. It is acknowledged that those living their lives in such housing and settlements suffer greater levels of spatial, economic and social exclusion from the benefits of urbanization that other segments of the urban population. Using a case study approach, this paper examines the range of challenges associated with the growth of informal settlements and slums, seeking to understand how they are positioned via upgrading policies in city urbanization plans and strategies in Indonesia’s third largest city, Bandung. The research finds that there has been a shift in kampung and slum upgrading policy from in-situ solutions to vertical housing towers which appear incompatible in accommodating the way of life practiced in kampung adaptive urbanism contexts. The manner in which city governments manage informal settlements and slums by seeking to reshape and restructure the lifestyles of residents to align with formal market measures has a major impact on existing disadvantaged communities. The paper concludes with a call for greater leadership, political commitment and recognition of contextual responses when developing slum upgrading policies set within urbanization policies and strategies branded as sustainable.
Changing Stem Cell Dynamics during Papillomavirus Infection: Potential Roles for Cellular Plasticity in the Viral Lifecycle and Disease
Authors: Strati Katerina
Published: August 2017

Stem cells and cellular plasticity are likely important components of tissue response to infection. There is emerging evidence that stem cells harbor receptors for common pathogen motifs and that they are receptive to local inflammatory signals in ways suggesting that they are critical responders that determine the balance between health and disease. In the field of papillomaviruses stem cells have been speculated to play roles during the viral life cycle, particularly during maintenance, and virus-promoted carcinogenesis but little has been conclusively determined. I summarize here evidence that gives clues to the potential role of stem cells and cellular plasticity in the lifecycle papillomavirus and linked carcinogenesis. I also discuss outstanding questions which need to be resolved.
Gemini/GMOS Transmission Spectral Survey: Complete Optical Transmission Spectrum of the Hot Jupiter WASP-4b
Authors: Huitson C. M. , Désert J.-M. , Bean J. L. , Fortney J. J. , Stevenson K. B. , Bergmann M.
Published: August 2017

We present the complete optical transmission spectrum of the hot Jupiter WASP-4b from 440 to 940 nm at R ∼ 400–1500 obtained with the Gemini Multi-Object Spectrometers (GMOS); this is the first result from a comparative exoplanetology survey program of close-in gas giants conducted with GMOS. WASP-4b has an equilibrium temperature of 1700 K and is favorable to study in transmission due to its large scale height (370 km). We derive the transmission spectrum of WASP-4b using four transits observed with the MOS technique. We demonstrate repeatable results across multiple epochs with GMOS, and derive a combined transmission spectrum at a precision about twice above photon noise, which is roughly equal to one atmospheric scale height. The transmission spectrum is well fitted with a uniform opacity as a function of wavelength. The uniform opacity and absence of a Rayleigh slope from molecular hydrogen suggest that the atmosphere is dominated by clouds with condensate grain sizes of ∼1 μm. This result is consistent with previous observations of hot Jupiters since clouds have been seen in planets with similar equilibrium temperatures to WASP-4b. We describe a custom pipeline that we have written to reduce GMOS time-series data of exoplanet transits, and present a thorough analysis of the dominant noise sources in GMOS, which primarily consist of wavelength- and time-dependent displacements of the spectra on the detector, mainly due to a lack of atmospheric dispersion correction.
Search for Hydrogenated C60 (Fulleranes) in Circumstellar Envelopes
Authors: Zhang 张 Yong 泳 , Sadjadi SeyedAbdolreza , Hsia 夏 Chih-Hao 志浩 , Kwok 郭 Sun 新
Published: August 2017

The recent detection of fullerene (C60) in space and the positive assignment of five diffuse interstellar bands to

reinforce the notion that fullerene-related compounds can be efficiently formed in circumstellar envelopes and be present in significant quantities in the interstellar medium. Experimental studies have shown that C60 can be readily hydrogenated, raising the possibility that hydrogenated fullerenes (or fulleranes, C60H
m
, m = 1–60) may be abundant in space. In this paper, we present theoretical studies of the vibrational modes of isomers of C60H
m
. Our results show that the four mid-infrared bands from the C60 skeletal vibrations remain prominent in slightly hydrogenated C60, but their strengths diminish in different degrees with increasing hydrogenation. It is therefore possible that the observed infrared bands assigned to C60 could be due to a mixture of fullerenes and fulleranes. This provides a potential explanation for the observed scatter of the C60 band ratios. Our calculations suggest that a feature around 15 μm due to the breathing mode of heavily hydrogenated C60 may be detectable astronomically. A preliminary search for this feature in 35 C60 sources is reported.
The Effect of a Twisted Magnetic Field on the Phase Mixing of the Kink Magnetohydrodynamic Waves in Coronal Loops
Authors: Ebrahimi Zanyar , Karami Kayoomars , Soler Roberto
Published: August 2017

There is observational evidence for the existence of a twisted magnetic field in the solar corona. This inspires us to investigate the effect of a twisted magnetic field on the evolution of magnetohydrodynamic (MHD) kink waves in coronal loops. With this aim, we solve the incompressible linearized MHD equations in a magnetically twisted nonuniform coronal flux tube in the limit of long wavelengths. Our results show that a twisted magnetic field can enhance or diminish the rate of phase mixing of the Alfvén continuum modes and the decay rate of the global kink oscillation depending on the twist model and the sign of the longitudinal (k

z
) and azimuthal (m) wavenumbers. Also, our results confirm that in the presence of a twisted magnetic field, when the sign of one of the two wavenumbers m and k

z
is changed, the symmetry with respect to the propagation direction is broken. Even a small amount of twist can have an important impact on the process of energy cascading to small scales.