bluuebunny/crossref_metadata_2025 huggingface dataset:
Early Developmental Stress Affects Subsequent Gene Expression Response to an Acute Stress in Atlantic Salmon: An Approach for Creating Robust Fish for Aquaculture?
Authors: Robinson Nicholas A , Johnsen Hanne , Moghadam Hooman , Andersen Øivind , Tveiten Helge
Published: March 2019

Stress during early life has potential to program and alter the response to stressful events and metabolism in later life. Repeated short exposure of Atlantic salmon to cold water and air during embryonic (E), post-hatch (PH) or both phases of development (EPH) has been shown to alter the methylome and transcriptome and to affect growth performance during later life compared to untreated controls (CO). The aim of this study was to investigate how the transcriptome of these fish responds to subsequent acute stress at the start feeding stage, and to describe methylation differences that might steer these changes. EPH treated fish showed the strongest down-regulation of corticotropin releasing factor 1, up-regulation of glucocorticoid receptor and 3-oxo-5-alpha-steroid 4-dehydrogenase 2 gene expression and a suppressed cortisol response 3 hr after the acute stress, differences that could influence hormesis and be affecting how EPH fish cope and recover from the stress event. Growth hormone 2 and insulin-like growth factor 1 were more strongly down-regulated following acute stress in EPH treated fish relative to E, PH and CO fish. This indicates switching away from growth toward coping with stress following stressful events in EPH fish. Genes implicated in immune function such as major histocompatibility class 1A, T-cell receptor and toll-like receptor also responded to acute stress differently in EPH treated fish, indicating that repeated stresses during early life may affect robustness. Differential DNA methylation was detected in regions mapping <500 bases from genes differentially responding to acute stress suggesting the involvement of epigenetic mechanisms. Stress treatments applied during early development therefore have potential as a husbandry tool for boosting the productivity of aquaculture by affecting how fish respond to stresses at critical stages of production.
Introducing Vernakalant into Clinical Practice
Authors: Hall Angela JM , Mitchell Andrew RJ
Published: March 2019

Vernakalant is an antiarrhythmic drug licensed for the pharmacological cardioversion of recent onset AF. Randomised clinical trials, backed up by real-world experience, have confirmed its efficacy at restoring sinus rhythm. Vernakalant can be administered simply with a short time to action, facilitating early discharge from hospital in selected patients in place of electrical cardioversion. The authors explore the data behind vernakalant and discuss how it can be introduced into clinical practice.
Complications of Cryoballoon Pulmonary Vein Isolation
Authors: Miyazaki Shinsuke , Tada Hiroshi
Published: March 2019

Since the cryoballoon (CB) was introduced into clinical practice, more than 400,000 patients have undergone a pulmonary vein (PV) isolation with a CB throughout the world. Although the efficacy of the first-generation CB was limited, the recently introduced secondgeneration CB has achieved a greater uniformity in cooling, which has facilitated a shorter time to PV isolation, shorter procedural times, higher rates of freedom from atrial fibrillation and low rates of PV reconnections. Currently, a single short freeze strategy with a single 28 mm balloon has become the standard technique based on the balance of procedural efficacy and safety. However, enhanced cooling characteristics may also result in a greater potential for collateral damage to non-cardiac structures. Knowledge about the potential complications is essential when performing the procedure. In this article, we describe the important complications that should be noted during a CB procedure, and how to minimise the risk of complications based on our experience.
Usefulness of heart rate recovery parameters to monitor cardiovascular adaptation in elite athletes: The impact of the type of sport
Authors: Durmić T , Ðjelić M , Gavrilović T , Antić M , Jeremić R , Vujović A , Mihailović Z , Zdravković M
Published: March 2019

Purpose

The purpose of this study is to determine heart rate (HR) recovery after maximal test in elite athletes who compete in high dynamic, high static, and in mixed sport disciplines; to assess differences in HR recovery between these groups of athletes; and to measure the association of HR index (HRI) with heart adaptation variables to determine whether these values were correlated with the type of exercise.

Methods

One hundred and ninety-four elite athletes were divided into three groups according to the predominant type of exercise performed: endurance (n = 40), strength-sprinter (n = 36), and ball-game players (n = 118). They performed maximal cardiopulmonary exercise testing on a treadmill and were subjected to echocardiography. The rate of decline (HR recovery) was calculated as the difference between maximum and recovery HRs (HRrec1 and HRrec3). The HRI was calculated as HRmax – 1-min post-exercise HR (HRrec1).

Results

The most significant correlation of HRI was with posterior wall diameter and left ventricular (LV) mass index (r = 0.43 and r = 0.51; p = 0.012 and p = 0.003, respectively). LV mass index [Beta (B) = 0.354, p = 0.001] was an independent predictor of HRI and HRrec1. HRI may be an effective tool for discrimination of physiological and “gray zone” LV hypertrophy, with area under the curve of 0.545 (95% CI = 0.421–0.669, p = 0.0432). HRI displayed a sensitivity of 50% and specificity of 52.2% at the optimal cut-off value of 23.5.

Conclusion

HR recovery pattern, especially HRI, may offer a timely and efficient tool to identify athletes with autonomous nervous system adaptive changes.
Qualidade percebida de serviço prestado por meio de mídia social de uma universidade federal
Authors: De Paula Pedro Alexandre , Bragança de Matos Eliane
Published: March 2019

O presente artigo traz uma análise da percepção da qualidade de serviço oferecido pela página do Facebook da instituição de ensino superior, pública, Universidade Federal de Ouro Preto (UFOP). Para tanto utiliza as teorias do Marketing: Lógica Dominante do Serviço (SDL) e Qualidade percebida em Serviço. A mensuração desta percepção foi feita por meio de um survey baseado nas dimensões de análise da escala SERVQUAL e com as opções de resposta baseadas na escala LIKERT.
Uma análise das medidas de desempenho das empresas brasileiras listadas nos níveis diferenciados de governança corporativa da BM&F-Bovespa
Authors: Oliveira Nunes Rodrigues Angelo Antonio Davis , Krauter Elizabeth
Published: March 2019

O objetivo da pesquisa é identificar quais as medidas contábeis podem ser agrupadas em fatores para melhor evidenciar o desempenho financeiro das empresas brasileiras com nível diferenciado de governança corporativa. Para o desenvolvimento desse trabalho é utilizada uma abordagem metodológica estruturada a partir de um problema de pesquisa quantitativo; com objetivo descritivo. Como procedimento técnico foi utilizado à análise multivariada fatorial dos principais indicadores contábeis. Essa análise foi realizada em uma amostra estatística das empresas listadas nos níveis diferenciados de governança corporativa na bolsa de valores do Brasil, com nível de confiança de 95% e com erro amostral de 5%, resultando em dezoito empresas.  A aplicação da análise fatorial evidenciou que 5 fatores são capazes de explicar 83,43% das variáveis e  explicam a forma como o desempenho, o giro do ativo e o fluxo de caixa impacto o endividamento das empresas.
LETRAMENTOS E TECNOLOGIAS DIGITAIS NA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Kleiman Angela Bustos , Santos Marques Ivoneide Bezerra de Araújo
Published: March 2019

Neste trabalho, nosso objetivo é discutir aspectos que envolvem o trabalho com as tecnologias digitais no processo educacional de alunos vinculados ao Ensino Médio Integrado no contexto específico da Educação de Jovens e adultos no PROEJA. Refletimos sobre ambiguidades e omissões nos documentos regulatórios do Ensino Médio que caracterizam o tratamento da Educação Profissional e Tecnológica nas diversas políticas públicas da federação que fornecem parâmetros importantes à discussão desenvolvida. Propomos alguns princípios que, uma vez observados, poderiam nortear o trabalho com as práticas de letramento desenvolvidas na EPT, para começar a atender às expectativas, necessidades de participação social e política dos estudantes. Concluímos que, enquanto os trabalhadores em formação ou outros possíveis alunos egressos da EPT continuarem chegando ao mundo do trabalho sem que a escola tenha dado respostas mais concretas às suas demandas de letramentos, esta continuará sendo reprodutora de desigualdades sociais, pois não garante aos educandos o direito aos letramentos como condição de acesso e permanência no mundo do trabalho e de inclusão social.
The personalistic concept of public administration and homelessness
Authors: Fundowicz Sławomir
Published: March 2019

This article deals with the issues of the personalistic concept of public administration in the context of homelessness. The concept of public administration was discussed, as well as the philosophical foundations of personalism, to get to the concept of a public task. It became necessary to analyse the dignity of the human person as well as the system of help for the homeless. Bearing in mind the personalistic concept of administrative law, the need to look at homelessness through the prism of a homeless person was stressed.
Rules of providing health services to homeless people
Authors: Sikorski Sebastian
Published: March 2019

The problem of providing healthcare services publicly funded is complex. The purpose of the article is the presentation of a certain fragment of these issues, which, in accordance with title, concerns the legal basis of providing healthcare services publicly funded for homeless people. There is only one legal basis in this regard dedicated straight for the homeless people, namely providing health insurance under individual programme of recovering from homelessness, which in view of the extent of the application plays hardly any role. Other legal solutions are provided for a wider range of categories of people for which the homeless people can be classified. As a result of analysis, the demands de lege ferenda shall be made in the area causing the major difficulties of the application in practice of the rules governing these issues.
The importance of social economy forms to counteract the phenomenon of homelessness
Authors: Małecka-Łyszczek Magdalena
Published: March 2019

The study analyzes selected forms of social economy through the prism of their “usefulness” in the inclusion of homeless people, in their empowerment. Therefore, it is about exposing what allows to overcome growing social exclusion, enabling a more complete participation of homeless people in social life, in communities forming within society.
Lipid Peroxidation State in Women of Reproductive Age with Acute Form of Viral Hepatitis
Authors: Kolesnikova L. I. , Darenskaya M. A. , Rashidova M. A. , Sholokhov L. F. , Grebenkina L. A. , Vanteeva O. A.
Published: March 2019

Objective: The objective of this study was to identify features of the lipid status and lipid peroxidation-antioxidant defense system in women of reproductive age with acute form of hepatitis. Methods: The study involved 36 women with acute viral hepatitis and 28 healthy women of the same age. Spectrophotometric and fluorometric methods were used. Results: In patients with acute viral hepatitis we detected an increase in triglycerides levels ― by 21% and very low density lipoprotein values — by 17% in relative to control group, high-density lipoprotein cholesterol content reduced by 38%. In group with acute viral hepatitis the TBA-reactive products level increased by 2.21 times and superoxide dismutase activity decreased by 1.43 times in comparison with control group. Conclusion: The acute form of hepatitis is characterized by series of metabolic disorders that require a more careful approach in therapeutic and diagnostic administration.
CRYPTOSPORIDIA AND MACROORGANISM: FACTORS THAT INFLUENCE ON THE DEVELOPMENT OF CRYPTOSPORIDIOSIS
Authors: Starikova E. G. , Voronkova O. V. , Kovshirina Yu. V. , Shubina N. I.
Published: March 2019

Cryptosporidiosis is a disease caused by unicellular parasites belonging to the Cryptosporidium genus. The small intestine is the primary site of localization of infection which predicts the main clinical symptom of the disease — diarrhea. The most important factors influencing Cryptosporidium infection and the course of disease are molecular genetic variability of the parasite, its virulence and infectivity, and viability of the mucosa of the digestive tract and local and systemic immunity of the macroorganism. The immune status of the host plays a key role in determining sensitivity to infection and the severity of the disease. Cryptosporidium infection differs in outcomes: asymptomatic in some patients, acute enteritis accompanied by profuse diarrhea, lesions of internal organs, and fatal outcome in others. Current therapeutic approaches to the treatment of cryptosporidiosis are ineffective. Despite the existence of a large number of drugs with antiparasitic effect, there are no medications with a specific effect on cryptosporidia. Understanding the factors that determine both the pathogenicity of Cryptosporidia and the protective properties of host defense systems will allow developing effective prevention measures and therapeutic interventions of this protozoosis.
"Meaning is a Physiognomy": Wittgenstein on Seeing Words and Faces
Authors: Scotto Carolina
Published: March 2019

The second part of Philosophical Investigations and other contemporary writings contain abundant material dedicated to the examination of visual perception, along the lines of similarities and differences manifested in the use of concepts such as “seeing as”, “seeing aspects”, “noticing the aspect”, “aspect blindness”, among other, related ones. However, the application of these concepts to phenomena such as face perception and word perception has not received proper attention in the literature. Our interest lies in identifying the features pertaining facial perception and recognition of its content in order to understand how and to what extent they contribute to shed light on perceptual (and experiential) relationships we have with language, in particular with its written form. In other words, we will try to show in what ways the “phenomenology of facial perception” or “physiognomy” helps to understand the “experience of meaning” and the “phenomenology of reading”. My interpretative hypothesis is that, in Wittgenstein’s view, the features shared by face and word perception are more profound than a mere analogy, and that, in the case of words, these features can explain specific semantic (perhaps, semantic-pragmatic) phenomena that should be included in an appropriate reconstruction of the varieties of use in natural languages.
Altıncı Sınıf Öğrencilerinin Paralel ve Dik Doğru/Doğru Parçalarını Belirleme ve Çizme Durumları
Authors: Duatepe Paksu Asuman , Bayram Gülcan
Published: March 2019

Bu araştırmanın
amacı, altıncı sınıf öğrencilerinin paralel ve dik doğru/doğru parçalarını
belirleme durumlarını ve çizme becerilerini incelemektir. Çalışmada nitel araştırma desenlerinden
özel durum çalışması kullanılmıştır. Veri toplama aracı olarak, araştırmacılar
tarafından geliştirilen öğrencilerin
verilen bir doğru parçasına paralel doğru parçaları çizme ve verilen bir doğru
üzerinde veya dışındaki bir noktadan doğruya dikme çizme edebilme becerileri
ile verilen doğru veya doğru parçalarından hangilerinin paralel veya dik
olduğunu belirleme durumlarını ortaya çıkarmaya yönelik 4 soruluk bir ölçek
kullanılmıştır. Verilerin analizi, betimsel analiz yöntemiyle
gerçekleştirilmiştir. Araştırma sonucunda öğrencilerin paralellik ve
diklikle ilgili hem çizme becerilerinin hem de belirleme durumlarının yatay
veya düşey olarak verilen doğrularda/doğru parçalarında daha iyi olduğu görülmüştür.
Ayrıca öğrencilerin paralellik ve diklikle ilgili düşüncelerinin ve çizme becerilerinin
verilen doğru çiftlerinin görüntüsüne göre değiştiği, öğrencilerin paralel ve
dik doğru çizmede, paralelliği ve dikliği belirlemeye göre daha iyi oldukları
sonucuna ulaşılmıştır.
Ebeveynlerin Akıllı Cihazlarda Kullanılan İçerik Tanımlama Standartları ile İlgili Farkındalıklarının İncelenmesi
Authors: ÖZTÜRK Gülcan , ŞAHİN Feyza
Published: March 2019

Son zamanlarda bilgi ve iletişim teknolojilerindeki
gerçekleşen gelişmeler sonucunda başta akıllı telefonlar olmak üzere
taşınabilir cihazlar her yaştan kullanıcı tarafından yoğun bir şekilde
kullanılmaya başlamıştır. Bu cihazlara kurulabilen ve çocuklar tarafından
sıklıkla kullanılan uygulamalarla ilgili bir takım içerik tanımlama ve yaş
derecelendirme standartları belirlenerek kullanıma sunulmuştur. Bu araştırmanın
amacı akıllı cihazlardaki uygulamalara ilişkin ebeveynlerin içerik tanımlama ve
yaş derecelendirme standartları konusundaki farkındalık durumlarını
incelemektir. Araştırmada nitel araştırma yaklaşımı benimsenmiş, veriler yarı
yapılandırılmış görüşme yöntemi kullanılarak toplanmıştır. Görüşmeler 2016–2017
öğretim yılı ikinci döneminde Batı Anadolu’da bir şehir merkezinde ikamet eden
2–16 yaş aralığında çocuğu olan ve akıllı cihaza sahip ebeveynler ile
gerçekleştirilmiştir. Katılımcılar amaçsal örnekleme yöntemlerinden ölçüt
örnekleme yöntemi ile belirlenmiştir. Görüşmelerden elde edilen veriler yazılı
hale getirildikten sonra içerik analizi yöntemi kullanılarak incelenip
kodlanmış ve kodlamalara göre sınıflandırılmıştır. Yapılan analizler sonucunda,
ebeveynlerin çoğunun içerik tanımlama ve yaş derecelendirme standartları
hakkında fikirlerinin olmadığı görülmüştür. Ebeveynler, cihaz şifreleme, veli
kontrol uygulamaları, güvenlik önlemleri gibi kısıtlamalar getirmeden
çocuklarının akıllı cihazları kullanmaları konusunda tedirginlik
hissettiklerini belirtmişler, uygulama marketinin ebeveyn kontrolü veya işletim
sisteminin yaş derecelendirme özelliğini kullanmadıklarını ifade etmişlerdir.
Araştırma sonucunda akıllı cihazların bilinçli kullanımına ve gelecek
araştırmalara yönelik birtakım önerilerde bulunulmuştur.
OKULLARDA İNFORMEL İLETİŞİMİ KULLANMA ÖLÇEĞİ GELİŞTİRME ÇALIŞMASI
Authors: Toytok Esef Hakan , Doğan Emine
Published: March 2019

İletişim
sosyal yaşamda olduğu gibi örgütler içinde önemli bir kavramdır. Genel olarak
iletişim formal ve informel olmak üzere ikiye ayrılmaktadır. İnformel iletişim
örgüt çalışanları tarafından etkileşim sonucunda oluşmaktadır. Bu iletişim
türünün olumlu olduğu kadar olumsuz özellikleri de bulunmaktadır. Bu çalışmada
ortaöğretim kurumlarında görev yapan öğretmenlerin informel iletişimi kullanma
biçim ve düzeylerini belirlemek ve informel iletişimin okullardaki olumlu ve
olumsuz etkilerini tespit etmek amacıyla bir ölçek geliştirilmesi
amaçlanmıştır. Geliştirilen ölçek toplam 1268 (n1= 970, n2=298) kişiye
uygulanmıştır. Birinci grubun verileriyle cevapların frekansları ve mod
değerleri belirlenmiş sonrasında açımlayıcı faktör analizi yapılmıştır.
Açımlayıcı faktör analizi sonucunda, ölçeğin 23 madde ve beş faktörden oluştuğu
tespit edilmiştir. Elde edilen yapının geçerliliği, doğrulayıcı faktör analizi
ile doğrulanmıştır. Ölçeğin alt faktörlerinin güvenirlik katsayıları .58 ile .
82 arasında değişmektedir. Elde edilen bulgular ölçeğin okullarda informel
iletişimin kullanılma biçim ve düzeyini belirlemek, olumlu ve olumsuz
sonuçlarını tespit etmek için geçerli ve güvenilir olduğunu göstermiştir.
Oral Tedizolid Phosphate Stepdown Therapy in Two Cases of Staphylococcus aureus Endocarditis in Intravenous Drug Abusers
Authors: Sakoulas George , Geriak Matthew
Published: March 2019

This study examines the successful use of early oral stepdown therapy with tedizolid in 2 cases of Staphylococcus aureus endocarditis in intravenous drug users. While oxazolidinones are not recommended as initial therapy, tedizolid may offer convenient oral step-down therapy once the patient is stabilized with intravenous antibiotics and surgery.
Floating Microspheres: Recent Researchs
Authors: Asija Rajesh
Published: March 2019

The purpose of writing this review on floating microspheres was to compile the recent literatureÃ‚Â with special focus on various gastro retentive approaches that have recently become leading methodologiesÃ‚Â in the field of orally controlled drug delivery to overcome physiological adversities such asÃ‚Â short gastric residence times and unpredictable gastric emptying times. Floating microspheres enhancesÃ‚Â drug bioavailability; reduce drug excretion and controlled drug delivery and better patient compliance.
A Case of Application of Bedside Continuous Renal Replacement Therapy on Treatment of MODS Caused by Fish Bile Poisoning
Authors: Zou Qi , Liu Cheng , Yu Gang , Deng Ximing , Yu Meiling
Published: March 2019

One case of 54 years old female patient was admitted to hospital due to vomiting and diarrhea for 3 days and abnormal renal function for 1 day. The patient appeared repeatedly vomiting and watery stools 6 hours after eating 2 grain of raw carp fish bile and gradually appeared oliguresis, whole body skin yellow dye and fever symptoms. The condition of patient had no improvement after visiting the emergency department of local county hospital. She was checked in department of nephropathy in our hospital for further diagnosis and treatment. Because the patient's condition was serious and the function of liver and kidney was damaged, diagnosed as severe multiple organ dysfunction syndrome (MODS), she was transferred to ICU rescue to protect the liver, maintain water and electrolyte balance, control blood sugar, improve the circulation and give other drug treatments and actively carry out bedside continuous renal replacement therapy. Then the body temperature and hemogram of the patients became normal, liver and kidney function improved obviously, urinary production became normal, skin yellow dye faded and vital signs became stable. The successful treatment of this patient indicated that bedside continuous renal replacement therapy can not only have a good support for the kidneys but also reduce the waterfall effect of inflammatory of patients with severe MODS, which has great therapeutic effect on the multi organ dysfunction caused by fish bile poisoning.
Antimicrobial Activity of the Ethanolic and Aqueous Extract of Vicia faba L. (Fabaceae) at Three Different Concentrations in the Absence and Presence of Zn(OAc)2.2H2O
Authors: Jagessar RC , Hope S , Issacs S , Crepaul Y
Published: March 2019

The aqueous and ethanolic extract of Passiflora edulis and Vicia faba L. (Fabaceae) exhibited antimicrobial activity against the pathogenic microorganisms: E. coli, S. aureus, K. pneumoniae and C. albicans. This was evaluated using the Disc Diffusion Assay under asceptic conditions. Antimicrobial activity wasn’t induced by the solvent, ethanol nor water. The highest AZOI was 153.9 mm2 and the lowest 12.56 mm2. Negligible Zone of Inhibition, ZOI were observed in several instances. The aqueous extract of the fruit also induced negligible Zone of Inhibition, ZOI. In comparison to the reference, Ampicillin and Nystatin, these values are less. As the concentration of the metal salt, Zn(OAc)2.2H2O and ethanolic extract increases, there seem to be a variation in antimicrobial activity. Zn(OAc)2.2H2O appears to intensify the antimicrobial activity of the plant ethanolic and aqueous extract. Zn (OAc)2.2H2O in the absence of any extracts exhibited antimicrobial activity. The AZOI range from 47.2 mm2 to 117.8 mm2. Antimicrobial selectivity was also observed in several instances.
Granisetron Transdermal System for Gastroparesis: A Prospective Study using the GCSI-Daily Diary
Authors: Heckert Jason , Schey Ron , Parkman Henry Paul
Published: March 2019

Granisetron transdermal system (GTS; Sancuso®), a patch delivering a 5-HT3 receptor antagonist, has been shown to improve nausea and vomiting in gastroparesis. Recent FDA guidance on gastroparesis suggests daily scoring of symptoms to show efficacy. Aim: Determine the efficacy and onset of therapeutic response of GTS in improving specific symptoms and overall symptoms of gastroparesis in patients with gastroparesis using a daily symptom diary for gastroparesis. Methods: Symptomatic patients with diabetic or idiopathic gastroparesis with nausea and/or vomiting were enrolled. Gastroparesis Cardinal Symptom Index Daily Diary (GCSI-DD) captured severity of symptoms at baseline for one week and during two weeks of treatment with GTS. Key Results: 14 patients (age 41.5±17 years; 13 females) with refractory gastroparesis (5 idiopathic, 9 diabetic) participated in this open label study. Nausea, early satiety, postprandial fullness, abdominal pain, GCSI-DD composite score, and overall symptom severity significantly improved (p<0.05) during treatment when compared to the baseline week. Nausea significantly decreased on day 5 (p<0.01) of treatment. Episodes of vomiting did not significantly change. Side effects included pruritus (2 patients) and redness (1) at the patch site, headache (1), constipation (1), and poor patch adherence (5). Conclusions & Inferences: GTS significantly reduced nausea severity in patients with gastroparesis. There were also significant improvements in early satiety, postprandial fullness, and abdominal pain. Nausea improvement occurred on the fifth day of treatment. Thus, GTS has therapeutic effect on nausea, as well as other gastroparesis symptoms, in patients with gastroparesis as captured using a daily diary for gastroparesis.
Toxic Optic Neuropathy secondary to Systemic Chloramphenicol for Septic Arthritis: Case Report
Authors: Okonkwo Arthur
Published: March 2019

Introduction – Chloramphenicol is a broad-spectrum antibiotic with excellent tissue penetration. Systemic use was popularised in the 1950s due to its affordability andease of preparation. It is now rarely used in developed countries due to its significant side effect profile including toxic optic neuropathy.

Case Description – A 68-year-old female presented to a neighbouring eye department with a 2-month history of bilateral visual deterioration, initially thought to be due to cataracts. However, due to the moderate cataract density and visual acuities of 6/60 and hand movements a medical history revealed that she had been taking systemic chloramphenicol for 6 months for chronic septic arthritis following a complicated total knee replacement. Following a normal ophthalmic examination besides reduced colour vision and constricted visual fields a diagnosis of toxic optic neuropathy secondary to chloramphenicol was made. Once systemic Chloramphenicol was stopped, her vision improved to 6/24 bilaterally although subjectively did not return to baseline.

Conclusion – Cataracts are a common cause of visual reduction, however, if the amount of cataract does not correlate with the extent of loss of visual acuity then an alternative cause must be considered. Early recognition of toxic neuropathy is key, as withdrawal of Chloramphenicol often results in improvement of visual symptoms.
Plant-Derived Drugs in Malaria Treatment
Authors: E Hempelmann
Published: March 2019

Every year 880,000 people are killed by malaria, mostof them children in impoverished regions of the worldlacking adequate medical care. While many preventativemeasures, such as mosquito nets have decreased theincidence of malaria, once the disease is contracted,it must be treated. Many plasmodial species havedeveloped a frightening resistance to antimalarial agents,making the search for new, effective antimalarial agentsan urgent priority of global importance.
Role and Advantageousness of Ketamine in Obese and Non-Obese Patients: Peri-Interventional Considerations
Authors: AA Weinbroum , U Amit
Published: March 2019

Obese and morbidly obese patients are a growing group of individuals that generates medical, social and economicproblems worldwide. They undergo various interventions that require anesthesia and/or analgesia. Despite theirhealthy look, these individuals are graded at high ASA physical status, mainly because of their impaired respiratoryand cardiovascular conditions, and the metabolic changes their body undergoes. Opioids are the default drugsfor perioperative analgesia. Nevertheless, their use has reached a frightening epidemic-like condition worldwide.Multimodal analgesia regimens have been recommended as a perioperative standard of care, particularly useful in theobese. These regimens employ combinations of opioids and non-opioid compounds that reciprocate each analgesicpotencies, thus providing superior pain relief at rest, movement, or on effort, while reducing opioid consumption andtheir concerned adverse effects. The most important perioperative IV adjuvant currently employed is ketamine thatsees resurgence among physicians from diverse medical specialties. After summarizing obese patients’ perioperativedrawbacks, this review will illustrate ketamine’s neuropharmacology, and will describe its therapeutic usefulness asan analgesic adjuvant. Since data regarding the use of the drug in obese patients is scarce, brief exemplifications ofits benefits in non-obese cohorts will be portrayed as well.
Current Strategies of Quetiapine Fumarate Delivery in Management of Bipolar Disorder and Schizophrenia
Authors: Patil Deepak , Pattewar(Patil) Seema , Paliwal Sarvesh Paliwal , Singh Gyanendra , Sharma Swapnil
Published: March 2019

Bipolar disorder is psychological illness with periodic episodes of mania and depression. Schizophrenia is a complex mental disorder identified by delusions, hallucinations, disorganized behavior, impaired cognitive ability, disorganized speech and sudden change in personality. In both the diseases quetiapine fumarate (QF) drug is worth important in today’s scenario. This review gives complete QF drug profile along with mechanism of action. Quetiapine alone is successful for acute bipolar depression and the prevention of mania/hypomania switching. Literature survey section of this review gives information about quetiapine in different dosage form. By this review one can explore the scale up of quetiapine fumarate not only with immediate release and sustained release dosage form but also with novel drug delivery system like solid lipid nanoparticle and nanostructured lipid carrier.
Use of Ketamine to Treat Depressive Symptoms in Schizoaffective Disorder
Authors: Freedman Isaac , Rabin Daniel , Pannu Prabhneet , Bandoo Tariq , Nandra Bal , Wiesman Irvin M , Podbielski Francis J
Published: March 2019

The use of subanesthetic ketamine infusions in treatment resistant depression and bipolar depression is becoming more common. Subanesthetic doses of ketamine cause the patient to dissociate, which was initially considered a side effect of this treatment; it is believed to play a role in a patient’s clinical improvement. Researchers attribute this result to an increase in brain-derived neurotrophic factor, a growth factor that stimulates the formation of new synaptic connections. Due to its psychogenic affect, ketamine treatment is less suitable for patients who experience mood disorders with psychotic features. Although symptomatic hallucinations seemingly conflict with the dissociative effects of ketamine, treatment of a patient with depressive type schizoaffective disorder revealed significant improvements in his depressive symptoms, demonstrating ketamine’s potential to be safely administered to patients with a variety of complex disorders.
Empreendedorismo e sustentabilidade: um novo “velho” paradigma do desenvolvimento
Authors: Morais Paulo Roberto Benegas de , Penedo Antonio Sergio Torres , Pereira Vinícius Silva
Published: March 2019

Para atingir o objetivo desse trabalho que é a convergência dos três pilares principais: Empreendedorismo, Sustentabilidade e Capital Social em Educação, este artigo apresenta uma revisão teórica sobre a sustentabilidade nos mais diversos segmentos da sociedade civil, empresarial e governamental. Para realizar essa revisão temática, foi definido como assunto da pesquisa e por consequência palavras chaves: empreendedorismo; desenvolvimento local; sustentabilidade. O período de pesquisa foi entre dezembro de 2014 à fevereiro de 2015. Os sites de busca foram: http://www.teses.usp.br; http://www.periodicos.capes.gov.br; http://www.scielo.br; http://scholar.google.com.br; http://ciencia.science.gov; http://www.sciencedirect.com; http://bdtd.ibict.br; http://eric.ed.gov/. Como resultado encontrado observou-se que no alcance desse modelo sustentável, não apenas novos padrões de produção e distribuição de bens e serviços e do uso dos recursos naturais devem ser almejados, mas necessita-se também repensar os padrões de consumo das próprias pessoas. Não só o esforço das organizações que desenvolvem e oferecem seus produtos e serviços sociais, mas também um posicionamento firme do poder público. Apoiar, capacitar, acompanhar e financiar a geração atual e futura dos empreendedores sociais e privados é crucial para se aumentar o estoque de Capital Social local. Pode-se concluir que a participação civil na criação e condução de projetos ou empreendimentos sociais é elemento fundamental na geração de capital social que só se concretiza na existência de capital humano ou, em última análise, com a participação de empreendedores privados e sociais. Nessa perspectiva a Educação Empreendedora pode trazer uma grande contribuição para a construção de uma sociedade economicamente viável, ambientalmente correta e socialmente justa.
Apresentação do Dossiê: Setenta Anos da Declaração Universal dos Direitos Humanos
Authors: Maia Tatiana Vargas , Pontin Fabrício
Published: March 2019

Apresentação do Dossiê
A Study on Room-Level Accuracy of Wi-Fi Fingerprinting-Based Indoor Localization Systems
Authors: ÇABUK Umut Can , DALKILIÇ Feriştah , DAĞDEVİREN Orhan
Published: March 2019

Global positioning system and other outdoor positioning mechanisms are
already subject to comprehensive research and development for almost half a
century. Conversely, indoor positioning services became a hot topic in the last
decade. Since GPS (and. other outdoor solutions) do not work reliably in most
indoor environments, researchers and developers are working on accurate
positioning solutions, especially tailored for indoor places. However; due to
walls, furniture, people and other obstacles, absolute location estimation is
very hard and expensive to achieve in indoor places. In addition, accuracy
needs depend on the scenario and application. In this study, we have studied the
feasibility of room-level location detection in home and office environments.
We have focused on examining the quality of room-wise detection accuracy of the
fingerprinting method that is applied along with standard Wi-Fi radio
infrastructure. We have conducted experiments in a multi-storey office building
made of concrete and aerated concrete bricks with many rooms, in which it is
significantly hard to accurately estimate the correct place of a thing, using
radio signals. To the best of our knowledge, our paper is the first study that
investigates the room-level accuracy of Wi-Fi fingerprinting-based indoor
localization systems. We have found out that, it is possible to feasibly
achieve room-level detection with good accuracy, via a pre-calculated room-specific
received signal strength indicator threshold value.
LHM Superstrate for High Directivity Microstrip Antenna
Authors: TÜTÜNCÜ Bilal , URUL Bülent
Published: March 2019

High antenna directivity is generally desirable for wireless
communication systems, whether terrestrial or based on satellites. Most of the
solutions proposed for improvement of the directivity of microstrip patch
antennas were to design array of several antennas. The particular disadvantage
of this method comes from the feeding of each antenna and also from the
coupling between each element. A suitable model to eliminate these two
disadvantages is to use a separate superstrate structure. For this purpose a
Left-Handed medium (LHM) superstrate used and presented in this study. Both the
reference antenna and proposed antenna are simulated, fabricated, and tested.
The simulation results show good agreement with the measurement results. It is
observed that the reference antenna directivity increased by 1.72 dB with the
proposed LHM superstrate according to the measurement results for 12 GHz
operating frequency
Analysis of the Effect of Water Flux to a Gas Zone after Through Tubing Perforations on Gas Production by Numerical Simulations
Authors: MEREY Şükrü
Published: March 2019

After perforating a gas
zone with through tubing perforation method, other possible gas zones are also
perforated from bottom to top accordingly. However, if one of these zones is
highly saturated with water, water might flow through the perforations where
gas production is possible. In this study, the water flux from upper
perforation to lower perforations where gas is available was simulated by using
TOUGH + RealGasBrine simulator. The effects of permeability, pressure
differences between zones, and salinity on water flux through gas zone were
investigated in this study. Permeability affects the behavior of water flux and
its amount to gas zone significantly. Similarly, these effects were seen for
the cases with pressure differences between zones and salinity in water zone
even though these effects are less than those observed in permeability cases.
It was observed that the duration of exposure of gas zone to water flux should
be kept minimum by applying well completion operations quickly to isolate water
zone and stop water flux from this zone to gas zone. After isolating water zone
with well completion operations, gas production simulations from gas zone were
conducted at a constant production pressure of 5 MPa. It was observed that gas
production from gas zone was retarded and water production from gas zone was
higher compared to the original cases without any water invasion. Even in a
long term of gas production, it is possible to observe the remarks of previous
water flux from upper zone after analyzing water saturation distribution
A Comparison of Color and Strength Properties of Various Paper Printed with Inkjet System Using Natural Inks
Authors: BİLDİK DAL Ahsen Ezel
Published: March 2019

Printing with natural inks to the paper essential for various area like
wrapping paper for foodstuff, paper cups etc. Therefore, the development of
stable and commercial natural ink is gaining importance. The production methods
and the surfaces chemicals (coating materials, fluorochemicals, sizing
materials etc.) of the paper affect the color of the natural inks, which
applied paper surface. The aim of this study is to evaluate the effect of
natural inks on various paper types. Ink samples are cyan, magenta, yellow,
black colors prepared to have the closest color properties to the commercial
inkjet printing inks in the market. Yellow Curcuma
longa extract, red Rosa canina
extract, cyan Indigofera tinctoria
extract, black Alkanna tinctora
extract selected to prepare natural ink. The differences between the commercial
ink and the natural ink applied paper samples CIE L* a* b* color values were
evaluated. The application made with a commercial inkjet printer. Then strength
properties of paper samples evaluated and compared. According to results,
bleached white chemical paper color results were closest to commercial ink
BIG DATA E INTELIGÊNCIA ARTIFICIAL: ASPECTOS ÉTICOS E LEGAIS MEDIANTE A TEORIA CRÍTICA
Authors: Mello Mariana Rodrigues Gomes de , Camillo Everton Da Silva , Dos Santos Beatriz Rosa Pinheiro
Published: March 2019

O estudo objetiva refletir sobre o Big Data e a Inteligência Artificial a partir de aspectos éticos e legais à luz da Teoria Crítica. Delimitou-se como objetivos específicos: i) recuperar material documental com aderência à proposta temática deste trabalho e ii) observar possíveis relações entre ética, legislação e Teoria Crítica no âmbito do Big Data e Inteligência Artificial. Levou-se em consideração a construção de uma pesquisa exploratória, de cunho teórico e de natureza qualiquantitativa e o uso das técnicas de bibliometria e close reading. Obteve-se como resultado que: i) a comunidade científica deve continuar trabalhando de maneira crítica as abordagens que se relacionam com universo Big Data e IA, almejando explorar suas potencialidades e transformar seu uso em algo benéfico, ético, legal e consciente frente às necessidades humanas de tomadas de decisão e ii) o Big Data e IA merecem discussões cada vez mais abrangentes em termos de sociedade e que envolvam, sobretudo, as redes sociais virtuais, dadas as fragilidades legislativas nesse campo que abrem margem à violação dos aspectos não apenas éticos e legais, bem como humanos.
POLÍTICA DE INDEXAÇÃO NO CONTEXTO DA BIBLIOTECA PÚBLICA: PESQUISA ETNOGRÁFICA COM OBSERVAÇÃO PARTICIPANTE E PROTOCOLO VERBAL INDIVIDUAL
Authors: Tolare Jessica Beatriz , Tartarotti Roberta Cristina Dal´Evedove
Published: March 2019

Na área de Produção e Organização da Informação, a indexação de documentos é um dos processos mais importantes no tratamento da informação documentária. Como forma de contribuir com os estudos de política de indexação em bibliotecas públicas, considerando o contexto de produção e organização da informação e visando a compreensão dos procedimentos de indexação para que sua realização atenda às necessidades dos bibliotecários e dos usuários, o objetivo da pesquisa é investigar a existência dos procedimentos de indexação em bibliotecas públicas. Para isso, foi aplicado um questionário seguido de observação participante com Protocolo Verbal para observação do processo de catalogação e indexação na Bibliotecas Municipais das cidades de Marília, Araraquara, Campinas, no Estado de São Paulo e Belo Horizonte no Estado de Minas Gerais. Os resultados revelaram que nenhuma das instituições possuem política de indexação registrada e sistematizada em um manual, os bibliotecários sentem dificuldades por não terem capacitação para a tarefa de indexação e os sistemas de informação automatizados utilizados para o catálogo online, quando existentes, são limitados e falhos na recuperação. Conclui-se que nas bibliotecas públicas há necessidade de aprimoramento dos métodos para a prática e qualidade da indexação mediante instrução e formação adequada aos profissionais e, sobretudo, para a elaboração de política de indexação sistematizada em manuais de procedimentos que resolva, inclusive, o problema de sistemas de informação automatizados falhos.
OCORRÊNCIAS DO CONCEITO "WEB SEMÂNTICA" NO GT2 DO ENANCIB: UMA ANÁLISE DE CONTEÚDO
Authors: Moreira Walter , Novaes Fernanda Carolina Pegoraro , Moraes Isabela Santana de , Davanzo Luciana
Published: March 2019

A Ciência da Informação, especificamente a área de Organização e Representação do Conhecimento, é responsável por organizar e estruturar as unidades do conhecimento por meio da elaboração de ferramentas que são aplicadas com a perspectiva de melhorar a representação dos conceitos e, desse modo, tornar mais precisa a recuperação da informação. Tendo isso e abordando as interfaces da web semântica, este trabalho objetiva investigar as publicações relacionadas à temática, visando identificar e refletir como está sendo tratada no Brasil. O corpus de análise constituiu-se de trabalhos científicos armazenados na BENANCIB que é a base de dados do Encontro Nacional de Pesquisa em Ciência da Informação (ENANCIB), especificamente no Grupo de Trabalho 2, Organização e Representação do Conhecimento. Recuperaram-se 129 artigos com os termos web semântica/semantic web e aplicadas três categorias de análise: conceitualização, aplicação e base teórica. Permite-se concluir que o aumento do consumo de informações via internet, é um aspecto propulsor para o progresso dos serviços ofertados pela web semântica, pois há a necessidade de uma melhor organização para posterior recuperação e descoberta do conhecimento, entende-se que para isso necessite maior atenção ao processo de indexação desses conteúdos informacionais, sobretudo à contribuição que a indexação automática ou semiautomática, baseada em processos linguísticos. Assim, é necessário que a Organização e Representação do Conhecimento se envolva mais com as definições conceituais destes termos, principalmente pelo fato do objeto de estudo desta área ser a informação e que também assuma a responsabilidade de aplicação dessas tecnologias.
BIG DATA E FILOSOFIA: NOVOS DESAFIOS PARA OS FILÓSOFOS
Authors: Nogueira Danúbio Viana , Broens Mariana Cláudia
Published: March 2019

Este artigo apresenta uma breve reflexão a respeito dos Big Data e de algumas das suas relaçõespossíveis com a filosofia, mais especificamente com a epistemologia e com a filosofia das ciências. Éabordado o problema filosófico da indução enquanto método investigativo, tal como apresentado porDavid Hume, a aplicação deste método nas ciências empíricas, e de que forma os Big Data estão sendopropostos como um novo método investigativo para estas ciências. Por fim, é apresentada a razão pelaqual acreditamos que os Big Data representam novos desafios para os filósofos atuais.
Transdisciplinaridade e interculturalidade: experiências vividas e compartilhadas no curso de educação intercultural indígena – UFG (2018)
Authors: Pereira Tamiris Maia Gonçalves , Araújo Ordália Cristina Gonçalves , Nazareno Elias
Published: March 2019

O presente artigo pretende apresentar os conceitos da “transdisciplinaridade” e da “interculturalidade crítica” que permearam as dinâmicas das aulas sobre o Tema Contextual Educação Intercultural Bilíngue e, sobretudo, evidenciar a contribuição dos estudantes indígenas em sala como representantes de suas epistemologias. Suas experiências apontaram para a importância de debates mais aprofundados em torno da diversidade, da diferença e da interculturalidade no contexto educacional brasileiro, discussão levantada a partir de três atividades didáticas propostas e realizadas durante as aulas, nas quais narrativas, textos escritos e documentos imagéticos foram desenvolvidos. As produções e reflexões foram fundamentadas nos princípios da “enação”, “transdisciplinaridade”, “interculturalidade crítica” (MATURANA, 2000; NASCIMENTO, 2014; VARELA; THOMPSON; ROSCH, 1992; WALSH, 2013; WALSH; VIAÑA; TAPIA, 2010) e em suas experiências educacionais. Ao analisarem seus conhecimentos e usos no cotidiano, os estudantes consideraram que, para além do conceito de “interculturalidade”, cunhado na década de 1970, na América Latina, o chamado “intercâmbio entre povos” (termo rememorado por eles durante as aulas) já existia como prática, mesmo antes de ser utilizado nas políticas públicas, na atualidade.
ФУНКЦИЈА И ПРЕВОД(ИВОСТ) ФРАЗЕОЛОГИЗАМА У ПЕСМИ „ВРАТИ МИ МОЈЕ КРПИЦЕ” ВАСКА ПОПЕ
Authors: Милованов Дајана
Published: March 2019

У овом раду се на примеру песме „Врати ми моје крпице” Васка Попе анализира функција и преводивост српских културно специфичних фразеологизама на енглески језик. Имајући на уму специфичне особине српског језика и метафоричну природу фразеологизама, циљ је био указати на изазов превођења поезије која је заснована на српској културно специфичној лексици. Попини фразеологизми су подељени у три групе (непромењени, „прерушени” и фразеологизми са промењеним значењем) и оригинална и преведена песма су компаративно анализиране с аспекта семантичке и структурне употребе фразеологизама. Поређењем оригинала и превода Ен Пенингтон, испитује се Попин поступак употребе, али и мистификације културног наслеђа садржаног у фразеологизмима с циљем да се понуди модел језичке анализе која би омогућила успешнији и прецизнији превод.