bluuebunny/crossref_metadata_2025 huggingface dataset:
Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes
Authors: Wu Xiaoming , Gao Yanbin , Xu Liping , Dang Wanyu , Yan Huimin , Zou Dawei , Zhu Zhiyao , Luo Liangtao , Tian Nianxiu , Wang Xiaolei , Tong Yu , Han Zheji
Published: August 2017

New data indicate that abnormal glomerular endothelial cell (GEC)-podocyte crosstalk plays a critical role in diabetic nephropathy (DN). The aim of our study is to investigate the role of exosomes from high glucose (HG)-treated GECs in the epithelial-mesenchymal transition (EMT) and dysfunction of podocytes. In this study, exosomes were extracted from GEC culture supernatants and podocytes were incubated with the GEC-derived exosomes. Here, we demonstrate that HG induces the endothelial-mesenchymal transition (EndoMT) of GECs and HG-treated cells undergoing the EndoMT secrete more exosomes than normal glucose (NG)-treated GECs. We show that GEC-derived exosomes can be internalized by podocytes and exosomes from HG-treated cells undergoing an EndoMT-like process can trigger the podocyte EMT and barrier dysfunction. Our study reveals that TGF-β1 mRNA is enriched in exosomes from HG-treated GECs and probably mediates the EMT and dysfunction of podocytes. In addition, our experimental results illustrate that canonical Wnt/β-catenin signaling is involved in the exosome-induced podocyte EMT. Our findings suggest the importance of paracrine communication via exosomes between cells undergoing the EndoMT and podocytes for renal fibrosis in DN. Thus, protecting GECs from the EndoMT and inhibiting TGF-β1-containing exosomes release from GECs is necessary to manage renal fibrosis in DN.
Distributed Optical Fiber Sensors with Ultrafast Laser Enhanced Rayleigh Backscattering Profiles for Real-Time Monitoring of Solid Oxide Fuel Cell Operations
Authors: Yan Aidong , Huang Sheng , Li Shuo , Chen Rongzhang , Ohodnicki Paul , Buric Michael , Lee Shiwoo , Li Ming-Jun , Chen Kevin P.
Published: August 2017

This paper reports a technique to enhance the magnitude and high-temperature stability of Rayleigh back-scattering signals in silica fibers for distributed sensing applications. With femtosecond laser radiation, more than 40-dB enhancement of Rayleigh backscattering signal was generated in silica fibers using 300-nJ laser pulses at 250 kHz repetition rate. The laser-induced Rayleigh scattering defects were found to be stable from the room temperature to 800 °C in hydrogen gas. The Rayleigh scatter at high temperatures was correlated to the formation and modification of nanogratings in the fiber core. Using optical fibers with enhanced Rayleigh backscattering profiles as distributed temperature sensors, we demonstrated real-time monitoring of solid oxide fuel cell (SOFC) operations with 5-mm spatial resolution at 800 °C. Information gathered by these fiber sensor tools can be used to verify simulation results or operated in a process-control system to improve the operational efficiency and longevity of SOFC-based energy generation systems.
Leukocyte TRP channel gene expressions in patients with non-valvular atrial fibrillation
Authors: Düzen Irfan V. , Yavuz Fethi , Vuruskan Ertan , Saracoglu Erhan , Poyraz Fatih , Göksülük Hüseyin , Candemir Basar , Demiryürek Seniz
Published: August 2017

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is a major cause of morbidity and mortality. The upregulation of TRP channels is believed to mediate the progression of electrical remodelling and the arrhythmogenesis of the diseased heart. However, there is limited data about the contribution of the TRP channels to development of AF. The aim of this study was to investigate leukocyte TRP channels gene expressions in non-valvular atrial fibrillation (NVAF) patients. The study included 47 NVAF patients and 47 sex and age matched controls. mRNA was extracted from blood samples, and real-time polymerase chain reaction was performed for gene expressions by using a dynamic array system. Low levels of TRP channel expressions in the controls were markedly potentiated in NVAF group. We observed marked increases in MCOLN1 (TRPML1), MCOLN2 (TRPML2), MCOLN3 (TRPML3), TRPA1, TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7, TRPV1, TRPV2, TRPV3, TRPV4, TRPV5, TRPV6, and PKD2 (TRPP2) gene expressions in NVAF patients (P < 0.05). However, there was no change in PKD1 (TRPP1) gene expression. This is the first study to provide evidence that elevated gene expressions of TRP channels are associated with the pathogenesis of NVAF.
Magnetic-Immuno-Loop-Mediated Isothermal Amplification Based on DNA Encapsulating Liposome for the Ultrasensitive Detection of P-glycoprotein
Authors: Cao Hongmei , Fang Xueen , Liu Peng , Li Hua , Chen Weiwei , Liu Baohong , Kong Jilie
Published: August 2017

Determination of proteins, especially low-abundance proteins with high sensitivity and specificity, is essential for characterizing proteomes and studying their biochemical functions. Herein, a novel Magnetic-Immuno-Loop-Mediated Isothermal Amplification (Im-LAMP) based on DNA-encapsulating liposomes (liposome-Im- LAMP), was developed for trace amounts of proteins. To the best of our knowledge, this is our first report about the magnetic Im-LAMP approach based on liposomes encapsulated template DNA as the detection reagent. The DNA template was released from liposomes and then initiated an Im-LAMP reaction, generating the fluorescence signal with high sensitivity and rapidity. This technique was applied for the determination of P-glycoprotein as a model protein. It was demonstrated that the technique exhibited a dynamic response to P-glycoprotein ranging from 1.6*10−2 to 160 pg/ml with a greatly low detection limit of 5*10−3 pg/ml (5 fg/ml) which is substantially better than conventional enzyme-linked immunosorbent assays (ELISA). This ultra sensitivity was attributed to the LAMP reaction initiated by the enormous DNA targets encapsulated in liposomes. This magnetic liposome-Im–LAMP as an alternative approach is attractive for applications in other low-abundance proteins detection in clinical diagnostics.
A Strategy for Nonmigrating Highly Plasticized PVC
Authors: Yuan Jun , Cheng Bin
Published: August 2017

Nonmigrating highly plasticized PVC was prepared based on a new compound that acts as a plasticizer that was derived from di(2-ethylhexyl) 4-hydrophthalate and chlorinated paraffin-52. The as-prepared PVC has a plasticizing efficiency as high as DOP and its migration is totally suppressed. Unlike other reported methods, this approach increases the interaction between phthalate and PVC to suppress its migration, not simply to enlarge its molecular size (or molecular weight). This methodology is highly versatile for producing the desired non-leaching PVC with a permanent plasticizer effect.
Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy
Authors: Jiang Jingwen , Wang Kui , Chen Yan , Chen Haining , Nice Edouard C , Huang Canhua
Published: August 2017

Epithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell metastasis and drug resistance, two leading causes of cancer recurrence and cancer-related death. It is, therefore, logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence. Previous reports have indicated that growth factors (such as epidermal growth factor and fibroblast growth factor) and cytokines (such as the transforming growth factor beta (TGF-β) family) are major stimulators of EMT. However, the mechanisms underlying EMT initiation and progression remain unclear. Recently, emerging evidence has suggested that reactive oxygen species (ROS), important cellular secondary messengers involved in diverse biological events in cancer cells, play essential roles in the EMT process in cancer cells by regulating extracellular matrix (ECM) remodeling, cytoskeleton remodeling, cell–cell junctions, and cell mobility. Thus, targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy. Herein, we will address recent advances in redox biology involved in the EMT process in cancer cells, which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment.
Promoting photocatalytic H2 evolution by tuning cation deficiency in La and Cr co-doped SrTiO3
Authors: Hui Jianing , Zhang Guan , Ni Chengsheng , Irvine John T. S.
Published: August 2017

A moderate cation deficiency in La and Cr co-doped SrTiO3 can increase the charge carrier mobility and promote the photocatalytic water reduction.
Selective reduction of carboxylic acids to aldehydes with hydrosilane via photoredox catalysis
Authors: Zhang Muliang , Li Nan , Tao Xingyu , Ruzi Rehanguli , Yu Shouyun , Zhu Chengjian
Published: August 2017

The direct reduction of carboxylic acids to aldehydes with hydrosilane was achieved through visible light photoredox catalysis.
Gold-catalyzed para-selective C–H bond alkylation of benzene derivatives with donor/acceptor-substituted diazo compounds
Authors: Ma Ben , Wu Jiaojiao , Liu Lu , Zhang Junliang
Published: August 2017

A gold(i)-catalyzed cascade C–H functionalization of unactivated arenes with α-aryl α-diazoesters with electron-withdrawing groups has been developed.
Tubulation of liposomes via the interaction of supramolecular nanofibers
Authors: Sugikawa Kouta , Takamatsu Yutaro , Kakigi Tomoyuki , Yasuhara Kazuma , Ikeda Atsushi
Published: August 2017

Rigid porphyrin assemblies work as scaffolds on liposome surfaces, inducing the gradual transformation of liposomes from vesicles to tubes.
Thermoelectric and piezoelectric properties of the predicted AlxIn1−xN composites based on ab initio calculations
Authors: Chang Yee Hui Robin , Yoon Tiem Leong , Lim Thong Leng , Tuh Moi Hua , Goh Eong Sheng
Published: August 2017

Theoretical investigations of the thermoelectric and piezoelectric characteristics in the AlxIn1−xN system have been carried out based on a first principles approach in combination with the semi-classical Boltzmann transport concept and density functional perturbation theory.
Photophysical characterization and time-resolved spectroscopy of a anthradithiophene dimer: exploring the role of conformation in singlet fission
Authors: Dean Jacob C. , Zhang Ruomeng , Hallani Rawad K. , Pensack Ryan D. , Sanders Samuel N. , Oblinsky Daniel G. , Parkin Sean R. , Campos Luis M. , Anthony John E. , Scholes Gregory D.
Published: August 2017

We investigate the singlet fission capability of an anthradithiophene dimer.
Understanding CO2 capture mechanisms in aqueous hydrazine via combined NMR and first-principles studies
Authors: Lee Byeongno , Stowe Haley M. , Lee Kyu Hyung , Hur Nam Hwi , Hwang Son-Jong , Paek Eunsu , Hwang Gyeong S.
Published: August 2017

Aqueous amines are currently the most promising solution for large-scale CO2 capture from industrial sources.
Reactions between microhydrated superoxide anions and formic acid
Authors: Ryding Mauritz Johan , Fernández Israel , Uggerud Einar
Published: August 2017

Reactions between water clusters containing the superoxide anion, O2˙−(H2O)n (n = 0–4), and formic acid, HCO2H, were studied experimentally in vacuo and modelled using quantum chemical methods.
The role of amino acid side chains in stabilizing dipeptides: the laser ablation Fourier transform microwave spectrum of Ac-Val-NH2
Authors: León I. , Alonso E. R. , Mata S. , Cabezas C. , Rodríguez M. A. , Grabow J.-U. , Alonso J. L.
Published: August 2017

The steric effects imposed by the isopropyl group of valine in the conformational stabilization of the capped dipeptide N-acetyl-l-valinamide (Ac-Val-NH2) have been studied by laser ablation molecular beam Fourier transform microwave (LA-MB-FTMW) spectroscopy.
Deciphering the mechanisms of selective inhibition for the tandem BD1/BD2 in the BET-bromodomain family
Authors: Cheng Chunyan , Diao Hongjuan , Zhang Fan , Wang Yongheng , Wang Kai , Wu Ruibo
Published: August 2017

The bromodomain and extra terminal domain (BET) family of bromodomains (BRDs) are well-known drug targets for many human diseases.
Two-dimensional GeP3 as a high capacity electrode material for Li-ion batteries
Authors: Zhang Chunmei , Jiao Yalong , He Tianwei , Ma Fengxian , Kou Liangzhi , Liao Ting , Bottle Steven , Du Aijun
Published: August 2017

Monolayer GeP3 is predicted to be an ideal anode material for lithium battery with ultrahigh-capacity, low diffuse barrier and low average open-circuit voltage.
Spatiotemporal hydrogel biomaterials for regenerative medicine
Authors: Brown Tobin E. , Anseth Kristi S.
Published: August 2017

This review highlights recent efforts in using photochemistry to exert dynamic control over the properties of hydrogel biomaterials.
A novel photo-active Cd:1,4-benzene dicarboxylate metal organic framework templated using [Ru(ii)(2,2′-bipyridine)3]2+: synthesis and photophysics of RWLC-5
Authors: Larsen Randy W. , Mayers Jacob M. , Wojtas Lukasz
Published: August 2017

The development of photoactive porous materials is of significant importance for applications ranging from sustainable energy to pharmaceutical development and catalysis.
New homoleptic bis(pyrrolylpyridiylimino) Mg(ii) and Zn(ii) complexes as catalysts for the ring opening polymerization of cyclic esters via an “activated monomer” mechanism
Authors: D'Auria Ilaria , Tedesco Consiglia , Mazzeo Mina , Pellecchia Claudio
Published: August 2017

The reaction of MgBu2 and ZnEt2 or Zn{N[Si(CH3)3]2}2 with a tridentate monoanionic pyrrolylpyridiylimino [N−,N,N] proligand gave homoleptic species, as exclusive products, in high yields.
In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells
Authors: Yuan Biao , Ma Ning , Zhao Liyan , Zhao Ermin , Gao Zili , Wang Weicang , Song Mingyue , Zhang Guodong , Hu Qiuhui , Xiao Hang
Published: August 2017

The inhibitory effects of a protein isolated from Pleurotus eryngii were demonstrated in both cell culture and mouse allograft tumor models.
Whole-cell biocatalytic selective oxidation of 5-hydroxymethylfurfural to 5-hydroxymethyl-2-furancarboxylic acid
Authors: Zhang Xue-Ying , Zong Min-Hua , Li Ning
Published: August 2017

HMF has been efficiently upgraded into HMFCA with a good yield by using a highly HMF-tolerant strainComamonas testosteroniSC1588.
Direct use of humic acid mixtures to construct efficient Zr-containing catalysts for Meerwein–Ponndorf–Verley reactions
Authors: Sha Yufei , Xiao Zhenhuan , Zhou Huacong , Yang Keli , Song Yinmin , Li Na , He Runxia , Zhi Keduan , Liu Quansheng
Published: August 2017

Humic acid (HA) mixtures from lignite could be directly used to construct Zr-HAs catalysts for MPV reaction of carboxyl compounds.
Computational design of biological circuits: putting parts into context
Authors: Karamasioti Eleni , Lormeau Claude , Stelling Jörg
Published: August 2017

We review computational approaches to deal with uncertainty and context-dependence in the design of synthetic gene circuits.
Advances in transferring chemical vapour deposition graphene: a review
Authors: Chen Mingguang , Haddon Robert C. , Yan Ruoxue , Bekyarova Elena
Published: August 2017

This review highlights recent developments in CVD graphene transfer methods from the perspective of mechanism, cleanness, quality, reliability, and cost.
Atp7a and Atp7b regulate copper homeostasis in developing male germ cells in mice
Authors: Ogórek Mateusz , Lenartowicz Małgorzata , Starzyński Rafał , Jończy Aneta , Staroń Robert , Doniec Andrzej , Krzeptowski Wojciech , Bednarz Aleksandra , Pierzchała Olga , Lipiński Paweł , Rajfur Zenon , Baster Zbigniew , Gibas-Tybur Patrycja , Grzmil Paweł
Published: August 2017

The maintenance of copper homeostasis is critical for normal process of spermatogenesis.
Structural, electronic, and magnetic properties of non-planar doping of BeO in graphene: a DFT study
Authors: Hussain Akhtar , Ullah Saif , Farhan M. Arshad , Saqlain Muhammad Adnan , Sato Fernando
Published: August 2017

The non-planar molecular doping of BeO is more efficient in inducing a band gap relative to its planar doping with no magnetic effect realization.
β-Configured clickable [18F]FDGs as novel18F-fluoroglycosylation tools for PET
Authors: Elgland M. , Nordeman P. , Fyrner T. , Antoni G. , Nilsson K. Peter R. , Konradsson P.
Published: August 2017

We have developed a chemoselective18F-fluoroglycosylation method for PET imaging that employ β-configured [18F]FDGs as prosthetic groups for18F-labeling using CuAAC click chemistry.
Highly conductive energy efficient electroless anchored silver nanoparticles on MWCNTs as a supercapacitive electrode
Authors: Pandit Bidhan , Sankapal Babasaheb R.
Published: August 2017

Electroless-deposited Ag nanoparticles over MWCNTs towards energy efficient supercapacitive electrodes.
Synthesis, characterization, in silico molecular docking study and biological evaluation of a 5-(phenylthio) pyrazole based polyhydroquinoline core moiety
Authors: Sapariya Nirav H. , Vaghasiya Beena K. , Thummar Rahul P. , Kamani Ronak D. , Patel Kirit H. , Thakor Parth , Thakkar Sampark S. , Ray Arabinda , Raval Dipak K.
Published: August 2017

A combinatorial library of polyhydroquinoline scaffolds is successfully attempted by multicomponent cyclocondensation reaction.
Organobase catalysed one-pot exo-selective synthesis of meso-spiro[cyclohexanone-pyrandione] derivatives
Authors: Talhi Oualid , Abdeldjebar Hasnia , Belmiloud Yamina , Hassaine Ridha , Taibi Nadia , Válega Mónica , Paz Filipe A. A. , Brahimi Meziane , Bachari Khaldoun , Silva Artur M. S.
Published: August 2017

A facile metal-free one-pot exo-stereoselective synthesis of through two sequential organobase-catalysed 1,4-conjugate additions of pyran-2,4-diones on diarylideneacetone synthons is disclosed.
New aspects of coordination chemistry and biological activity of NTMP-related diphosphonates containing a heterocyclic ring
Authors: Gałȩzowska J. , Czapor-Irzabek H. , Janicki R. , Chmielewska E. , Janek T.
Published: August 2017

Two aminodiphosphonic chelating agents are studied toward a series of metal ions (Cu2+, Ni2+, Zn2+, Ca2+, Mg2+) to give a thermodynamic picture of their binding abilities and the influence of free ligands and their complexes on human melanoma and human colon adenocarcinoma cells.
Electron-donating abilities and luminescence properties of tolane-substituted nido-carboranes
Authors: Nishino Kenta , Morisaki Yasuhiro , Tanaka Kazuo , Chujo Yoshiki
Published: August 2017

The luminescence properties of nido-carborane-substituted tolane derivatives were investigated.
Catalyst-free synthesis of 3-sulfone nitrile from sulfonyl hydrazides and acrylonitrile in water
Authors: Li Wei , Gao Lingfeng , Zhuge Wenyun , Sun Xu , Zheng Gengxiu
Published: August 2017

A novel catalyst-free sulfonation reaction for synthesizing 3-sulfone nitrile compounds from sulfonyl hydrazides and acrylonitriles in water, without any metal catalyst, ligand or organic solvent, was demonstrated.
A computational study of the influence of methyl substituents on competitive ring closure to α- and β-lactones
Authors: Wilson Philippe B. , Williams Ian H.
Published: August 2017

gem-Dimethyl substitution at C3 enhances the preference for β-lactone formation from 2-chlorosuccinate but methylation at C2 almost favours α-lactone.
Selective synthesis of tetrahydroimidazo[1,2-a]pyridine and pyrrolidine derivatives via a one-pot two-step reaction
Authors: Zhang Yu , Sun Jing , Shen Guo-Liang , Yan Chao-Guo
Published: August 2017

In the presence of triethylamine, the addition reaction of substituted α-amino acid alkyl esters with dialkyl but-2-ynedioate afforded active β-enamino esters, which in turn reacted with aromatic aldehydes and malononitrile to give tetrahydroimidazo[1,2-a]pyridine derivatives in moderate yields.
Inserting AgCl@rGO into graphene hydrogel 3D structure: synergy of adsorption and photocatalysis for efficient removal of bisphenol A
Authors: Chen Fangyuan , Zhao Junxiu , An Weijia , Hu Jinshan , Liang Yinghua , Cui Wenquan
Published: August 2017

An AgCl@graphene (rGO) core–shell structure was fabricated and then loaded into reduced graphene oxide hydrogel (rGH) to form AgCl@rGO-rGH by the chemical reduction method.
Theoretical studies on the structure and thermochemistry of cyclicparaphenylenediazenes
Authors: Ali Mohamad Akbar , Alam Mohammad A.
Published: August 2017

Comparison of thermochemistry of carbon nanoring structures.
A rolling circle amplification signal-enhanced immunosensor for ultrasensitive microcystin-LR detection based on a magnetic graphene-functionalized electrode
Authors: He Zuyu , Wei Jie , Gan Cuifen , Liu Weipeng , Liu Yingju
Published: August 2017

Construction of a rolling circle amplification signal-enhanced immunosensor for ultrasensitive microcystin-LR detection by using a magnetic graphene functionalized electrode.
Biological fate of food nanoemulsions and the nutrients they carry – internalisation, transport and cytotoxicity of edible nanoemulsions in Caco-2 intestinal cells
Authors: Wooster Tim J. , Moore Sean C. , Chen Wei , Andrews Helen , Addepalli Rama , Seymour Robert B. , Osborne Simone A.
Published: August 2017

Internalisation of edible food nanoemulsions by CaCo-2 intestinal cells. The structure of edible nanoemulsions increases five times upon incorporation of reactive/ROS producing nutrients/APIs.
Tuning interfacial patterns of molecular bonds via surface morphology
Authors: Yu Sai , Wang Hailong , Ni Yong , He Linghui , Huang Mingyuan , Lin Yuan , Qian Jin , Jiang Hongyuan
Published: August 2017

Effectively programmable patterning of bond clusters can be achieved through designed surface morphology.
Applications and limitations of two step metal oxide thermochemical redox cycles; a review
Authors: Bulfin B. , Vieten J. , Agrafiotis C. , Roeb M. , Sattler C.
Published: August 2017

A critical review of thermochemical redox cycles as a means of converting heat to chemical energy and subsequent applications.
Perovskite framework NH4FeF3/carbon composite nanosheets as a potential anode material for Li and Na ion storage
Authors: Kong Minhong , Liu Kunhong , Ning Jinyu , Zhou Jisheng , Song Huaihe
Published: August 2017

Perovskite framework NH4FeF3/CNS composites were prepared by an in situ co-pyrolysis method and exhibit better performance as anodes for both LIBs and SIBs.
Spin filtering of a termination-controlled LSMO/Alq3 heterojunction for an organic spin valve
Authors: Lam Tu-Ngoc , Huang Yen-Lin , Weng Ke-Chuan , Lai Yu-Ling , Lin Ming-Wei , Chu Ying-Hao , Lin Hong-Ji , Kaun Chao-Cheng , Wei Der-Hsin , Tseng Yuan-Chieh , Hsu Yao-Jane
Published: August 2017

La1−xSrxMnO3 (LSMO) is well known as an efficient spin-injection electrode in ferromagnetic–organic hybrid-based organic spin valves (OSV).
Two-dimensional hexagonal M3C2 (M = Zn, Cd and Hg) monolayers: novel quantum spin Hall insulators and Dirac cone materials
Authors: Liu Peng-Fei , Zhou Liujiang , Tretiak Sergei , Wu Li-Ming
Published: August 2017

Two-dimensional hexagonal M3C2 (M = Zn, Cd and Hg) monolayers with a linear geometry (CMC): novel quantum spin hall insulators and Dirac cone materials.
First observation of mutual energy transfer of Mn4+–Er3+via different excitation in Gd2ZnTiO6:Mn4+/Er3+phosphors
Authors: Liao Jinsheng , Wang Qi , Wen He-Rui , Yuan Huali , Liu Sui-Jun , Fu Junxiang , Qiu Bao
Published: August 2017

Mutual sensitized luminescence of Mn4+–Er3+are realizedviadifferent excitation in Gd2ZnTiO6:Mn4+/Er3+phosphors. The upconversion from Er3+to Mn4+is first observed under 980 nm excitation. The downshift from Mn4+to Er3+is observed under 335 nm.
New hybrid polyoxovanadate–Cu complex with V⋯H interactions and dual aqueous-phase sensing properties for picric acid and Pd2+: X-ray analysis, magnetic and theoretical studies, and mechanistic insights into the hybrid's sensing capabilities
Authors: Raizada Mukul , Sama Farasha , Ashafaq Mo , Shahid M. , Ahmad Musheer , Siddiqi Zafar A.
Published: August 2017

A new hybrid material for sensing picric acid and palladium cation in aqueous medium is synthesized and characterized.
The AAA+ ATPase p97, a cellular multitool
Authors: Stach Lasse , Freemont Paul S.
Published: August 2017

The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a wide range of cellular functions, including endoplasmic reticulum-associated degradation, membrane fusion, NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and chromatin-associated processes, which are regulated by ubiquitination. p97 acts downstream from ubiquitin signaling events and utilizes the energy from ATP hydrolysis to extract its substrate proteins from cellular structures or multiprotein complexes. A multitude of p97 cofactors have evolved which are essential to p97 function. Ubiquitin-interacting domains and p97-binding domains combine to form bi-functional cofactors, whose complexes with p97 enable the enzyme to interact with a wide range of ubiquitinated substrates. A set of mutations in p97 have been shown to cause the multisystem proteinopathy inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia. In addition, p97 inhibition has been identified as a promising approach to provoke proteotoxic stress in tumors. In this review, we will describe the cellular processes governed by p97, how the cofactors interact with both p97 and its ubiquitinated substrates, p97 enzymology and the current status in developing p97 inhibitors for cancer therapy.
Dépistage et évaluation des surdités de transmission chez l’enfant
Authors: Loundon Natalie
Published: August 2017

Le dépistage de la surdité en maternité est effectif en France depuis 2012. Ce dépistage conduit à diagnostiquer de façon précoce les
surdités moyennes à profondes. Dans le cas de surdités moyennes de transmission, le diagnostic est rendu diffi cile par les facteurs
transitoires intriqués liés au rétrécissement du conduit auditif externe et aux épanchements rétrotympaniques. Il faut donc savoir faire
la part du contexte et temporiser si nécessaire avant d’affi rmer qu’il existe une surdité permanente moyenne mais sans retarder le
diagnostic qui est à faire dès que possible. Les différents contextes et les stratégies sont décrits dans ce document.
Validation en français d’un système portable d’enregistrement et de reconnaissance automatique de la parole (LENATM) : intérêts et limites pour la recherche clinique chez l’enfant
Authors: Le Normand Marie-Thérèse , Canault Mélanie , Thai-Van Hung
Published: August 2017

Le système LENATM (Language ENvironment Analysis) créé en 2008 peut enregistrer jusqu’à 16 heures de données de langage recueillies
de manière naturelle et écologique dans l’environnement familial ou éducatif de l’enfant. Les algorithmes acoustiques développés par
leurs concepteurs permettent de détecter tous les segments de l’enregistrement qui correspondent à la parole de l’enfant ou à celle
d’un adulte, au bruit de la télévision ou de la radio, ou encore à du silence. Ainsi, ce système détecte automatiquement le signal de la
parole à proximité ou à distance de l’enfant ainsi que le bruit environnant et mesure très rapidement le nombre des productions de
l’enfant, de l’adulte ainsi que les tours de parole de l’adulte en interaction avec l’enfant. Plusieurs études ayant utilisé la technologie
LENATM ont démontré sa validité, ce que nous avons pu récemment confi rmer pour la langue française. Cette nouvelle méthode de
reconnaissance automatique de la parole ouvre ainsi une voie très prometteuse dans le domaine de la recherche sur le développement
du langage de l’enfant.
How film genres are a product of biology, evolution and culture—an embodied approach
Authors: Grodal Torben
Published: August 2017

The article describes how basic cognitive and emotional systems of the embodied brain are products of a long evolutionary history and how this determines the way in which the major film genres are constructed. It synthesizes research from evolutionary psychology and cognitive film studies, as well as moral psychology. It explains how the film experience is embodied: experienced not only cognitively but with the whole body and its interaction with the world. Also discussed is how the biological underpinning of genres are based on three major types of emotions: a group of reptilian emotions central to action and adventure; a group ofmammalianemotions related to offspring of care; and separation panic/grief. A special human development to enhance group living has expanded emotions of care to also underpin emotions linked to group living such as loyalty to tribe, aggression towards out-groups and submission to tribal hierarchy, central in war, sci-fi and fantasy films, and also emotions related to social rituals such as comedy, tragedy and musical. A discussion is also offered of how the historical development from hunter-gatherers via societies based on agriculture to the present post-agrarian society has moulded moral emotions; this is exemplified in relation to crime films. Finally, also considered is how age and gender influence genre preferences.
Temperature dependence of the hydrated electron’s excited-state relaxation. II. Elucidating the relaxation mechanism through ultrafast transient absorption and stimulated emission spectroscopy
Authors: Farr Erik P. , Zho Chen-Chen , Challa Jagannadha R. , Schwartz Benjamin J.
Published: August 2017

The structure of the hydrated electron, particularly whether it exists primarily within a cavity or encompasses interior water molecules, has been the subject of much recent debate. In Paper I [C.-C. Zho et al., J. Chem. Phys. 147, 074503 (2017)], we found that mixed quantum/classical simulations with cavity and non-cavity pseudopotentials gave different predictions for the temperature dependence of the rate of the photoexcited hydrated electron’s relaxation back to the ground state. In this paper, we measure the ultrafast transient absorption spectroscopy of the photoexcited hydrated electron as a function of temperature to confront the predictions of our simulations. The ultrafast spectroscopy clearly shows faster relaxation dynamics at higher temperatures. In particular, the transient absorption data show a clear excess bleach beyond that of the equilibrium hydrated electron’s ground-state absorption that can only be explained by stimulated emission. This stimulated emission component, which is consistent with the experimentally known fluorescence spectrum of the hydrated electron, decreases in both amplitude and lifetime as the temperature is increased. We use a kinetic model to globally fit the temperature-dependent transient absorption data at multiple temperatures ranging from 0 to 45 °C. We find the room-temperature lifetime of the excited-state hydrated electron to be 137±40 fs, in close agreement with recent time-resolved photoelectron spectroscopy (TRPES) experiments and in strong support of the “non-adiabatic” picture of the hydrated electron’s excited-state relaxation. Moreover, we find that the excited-state lifetime is strongly temperature dependent, changing by slightly more than a factor of two over the 45 °C temperature range explored. This temperature dependence of the lifetime, along with a faster rate of ground-state cooling with increasing bulk temperature, should be directly observable by future TRPES experiments. Our data also suggest that the red side of the hydrated electron’s fluorescence spectrum should significantly decrease with increasing temperature. Overall, our results are not consistent with the nearly complete lack of temperature dependence predicted by traditional cavity models of the hydrated electron but instead agree qualitatively and nearly quantitatively with the temperature-dependent structural changes predicted by the non-cavity hydrated electron model.
Influence of an external axial magnetic field on betatron radiation from the interaction of a circularly polarized laser with plasma
Authors: Du Bao , Wang Xiao-Fang
Published: August 2017

In this paper, theoretical analyses and numerical calculations are carried out to investigate the influence of an externally applied axial constant magnetic field on electrons' betatron radiation when an ultra-short, circularly polarized laser pulse of a peak intensity I0 = 5 × 1019 W/cm2 propagates in plasma of an electron density n0 = 1020/cm3. Ring-like x-ray radiation is emitted from the electrons' betatron oscillations. The applied magnetic field can modulate the resonance process between an electron's betatron oscillation and the laser electric field, and the electron energy gain from the direct laser acceleration is thus changed. When a magnetic field of strength B0=3 × 103 T is applied, which is in anti-parallel to the self-generated axial magnetic field, both the trapping efficiency of electrons by the wakefield and the maximum accelerated energy are increased. The maximum electron energy, the peak of angular radiation, and the total radiation energy are increased by 11.0%, 45.6%, and 41.1%, respectively, and the radiation spectra are blue-shifted significantly.
Observation of broadband terahertz wave generation from liquid water
Authors: Jin Qi , E Yiwen , Williams Kaia , Dai Jianming , Zhang X.-C.
Published: August 2017

Bulk liquid water is a strong absorber in the terahertz (THz) frequency range, due to which liquid water has historically been sworn off as a source for THz radiation. Here, we experimentally demonstrate the generation of broadband THz waves from liquid water excited by femtosecond laser pulses. Our measurements reveal the critical dependence of the THz field upon the relative position between the water film and the focal point of the laser beam. The THz radiation from liquid water shows distinct characteristics when compared with the THz radiation from air plasmas with single color optical excitation. First, the THz field is maximized with the laser beam of longer pulse durations. In addition, the p-polarized component of the emitted THz waves will be influenced by the polarization of the optical excitation beam. It is also shown that the energy of the THz radiation is linearly dependent on the excitation pulse energy.
Novel permutation-diffusion image encryption algorithm with chaotic dynamic S-box and DNA sequence operation
Authors: Tian Ye , Lu Zhimao
Published: August 2017

The development of the computer network makes image files transportation via network become more and more convenient. This paper is concerned with the image encryption algorithm design based on the chaotic S-box mechanism. This paper proposes an Image Encryption algorithm involving both chaotic dynamic S-boxes and DNA sequence operation(IESDNA). The contribution of this paper is three folded: Firstly, we design an external 256-bit key to get large key space; secondly, we design a chaotic system to scramble image pixels; thirdly, DNA sequence operations are adopted to diffuse the scrambled image pixels. Experimental results show that our proposed image encryption algorithm can meet multiple cryptographic criteria and obtain good image encryption effect.
Organic ion association in aqueous phase and ab initio-based force fields: The case of carboxylate/ammonium salts
Authors: Houriez Céline , Vallet Valérie , Réal Florent , Meot-Ner (Mautner) Michael , Masella Michel
Published: August 2017

We performed molecular dynamics simulations of carboxylate/methylated ammonium ion pairs solvated in bulk water and of carboxylate/methylated ammonium salt solutions at ambient conditions using an ab initio-based polarizable force field whose parameters are assigned to reproduce only high end quantum computations, at the Møller-Plesset second-order perturbation theory/complete basis set limit level, regarding single ions and ion pairs as isolated and micro-hydrated in gas phase. Our results agree with the available experimental results regarding carboxylate/ammonium salt solutions. For instance, our force field approach predicts the percentage of acetate associated with ammonium ions in CH3COO−/CH3NH3+ solutions at the 0.2–0.8M concentration scale to range from 14% to 35%, in line with the estimates computed from the experimental ion association constant in liquid water. Moreover our simulations predict the number of water molecules released from the ion first hydration shell to the bulk upon ion association to be about 2.0 ± 0.6 molecules for acetate/protonated amine ion pairs, 3.1 ± 1.5 molecules for the HCOO−/NH4+ pair and 3.3 ± 1.2 molecules for the CH3COO−/(CH3)4N+ pair. For protonated amine-based ion pairs, these values are in line with experiment for alkali/halide pairs solvated in bulk water. All these results demonstrate the promising feature of ab initio-based force fields, i.e., their capacity in accurately modeling chemical systems that cannot be readily investigated using available experimental techniques.
On the theory of the proton dipolar-correlation effect as a method for investigation of segmental displacement in polymer melts
Authors: Lozovoi A. , Petrova L. , Mattea C. , Stapf S. , Rössler E. A. , Fatkullin N.
Published: August 2017

A thorough theoretical description of the recently suggested method [A. Lozovoi et al. J. Chem. Phys. 144, 241101 (2016)] based on the proton NMR dipolar-correlation effect allowing for the investigation of segmental diffusion in polymer melts is presented. It is shown that the initial rise of the proton dipolar-correlation build-up function, constructed from Hahn Echo signals measured at times t and t/2, contains additive contributions from both inter- and intramolecular magnetic dipole-dipole interactions. The intermolecular contribution depends on the relative mean-squared displacement of polymer segments from different macromolecules, which provides an opportunity for an experimental study of segmental translational motions at the millisecond range that falls outside the typical range accessible by other methods, i.e., neutron scattering or NMR spin echo with the magnetic field gradients. A comparison with the other two proton NMR methods based on transverse spin relaxation phenomena, i.e., solid echo and double quantum resonance, shows that the initial rise of the build-up functions in all the discussed methods is essentially identical and differs only in numerical coefficients. In addition, it is argued that correlation functions constructed in the same manner as the dipolar-correlation build-up function can be applied for an experimental determination of a mean relaxation rate in the case of systems possessing multi-exponential magnetization decay.
From structure to structural dynamics: Ahmed Zewail's legacy
Authors: Chergui Majed , Thomas John Meurig
Published: August 2017

In this brief tribute to Ahmed Zewail, we highlight and place in the historical context, several of the major achievements that he and his colleagues have made in Femtochemistry (of which he was the principal instigator) and his introduction of ultrafast electron scattering, diffraction, microscopy and spectroscopy. By achieving a sub-picosecond temporal resolution, coupled with a picometer spatial resolution, he revolutionised our understanding of the corpus of chemical, physical, biological and materials science systems.
Polar ordering and structural distortion in electronic domain-wall properties of BiFeO3
Authors: Chen Yun-Wen , Kuo Jer-Lai , Chew Khian-Hooi
Published: August 2017

Bandgaps, band edges, and structural properties of domain walls (DWs) in multiferroic BiFeO3 (BFO) are studied using density functional theory. The ferroelectric DWs (namely, the 71°, 109°, and 180° DWs) in rhombohedral BFO are considered, with a view of critically examining the relationships between local bandgap, polar ordering, and octahedral distortion reported for this material. Our study reveals that the domain-wall electronic properties of BFO sensitively depend on the polarization behavior and structural distortion at the wall center. The value of the bandgap at the wall decreases with the weakening of ferroelectricity at the wall center. Compared to all the wall types, DWs with the paraelectric-like phase at the wall center exhibit a significantly reduced bandgap. The bandgap reduction is also found to be closely related to two key parameters of the octahedral distortion at the wall: Fe-O bonds and O-Fe-O angles. The reduction in the Fe-O bond deviation and the straightening in the O-Fe-O angles at the wall appear with a marked bandgap reduction in the BFO DWs. Such a structural change at BFO DWs is reminiscent of a cubic structure, which is consistent with the analysis of paraelectric-like behavior at DWs. However, our analysis reveals that the straightening of Fe-O-Fe does not have any obvious correlation with bandgap reduction as suggested in previous works. The influence of the octahedral distortion at DWs is further clarified by investigating the bandgap and structural properties of various BFO bulk phases including Pnma, Pna21, tetragonal (P4mm), and Amm2. Our result establishes important correlations between electronic properties, polar ordering, and structural distortion in BFO DWs. This study also suggests that photo nanocatalysts employing BFO DWs may be a promising strategy to enhance photocatalytic activity.
Dynamo transition in a five-mode helical model
Authors: Kumar Rohit , Wahi Pankaj
Published: August 2017

We construct a five-mode helical dynamo model containing three velocity and two magnetic modes and solve it analytically. This model exhibits dynamo transition via supercritical pitchfork bifurcation. We show that the critical magnetic Reynolds number for dynamo transition (Rmc) asymptotes to constant values for very low and very high magnetic Prandtl numbers (Pm). Beyond dynamo transition, secondary bifurcations lead to periodic, quasi-periodic, and chaotic dynamo states as the forcing amplitude is increased and chaos appears through a quasi-periodic route.
A novel methodology of round-year thermal performance evaluation for solar heaters in real weather conditions
Authors: Diego-Ayala U. , Carrillo J. G.
Published: August 2017

Currently, there is limited information regarding the performance of solar heaters in a round-year period under real weather conditions and the determination of their characteristic equation following standard methods. Therefore, this study presents a methodology to determine the characteristic equation of the annual thermal performance under real conditions based on uncertainty and linear regression analysis estimation. With this methodology, it is possible to analyze daily experimental data in a collector that has not been restricted to any particular requirement of evaluation standards. This methodology was applied to evaluate a flat plate solar heater operating in Mexico over a period of one year in two operating modes: thermosyphon and forced circulation. In the case of forced circulation, a small submersible pump was implemented, the activation of which was controlled by using a thermostat, thereby providing an effective control of the flow and temperature of the collector. The results indicated that the methodology was adequate to identify the level of uncertainty in a line of the best fit, which allowed the determination of a characteristic equation that reflects the operation of the heater under real conditions, in a round-year period. As a result of the application of this methodology, it was observed that the use of a submersible pump and a thermostat increases the efficiency throughout a whole year by 0.06, whereas the continuous use of a pump increases efficiency by 0.17, with respect to the operation in the thermosyphon mode.
Thermodynamic hardness and the maximum hardness principle
Authors: Franco-Pérez Marco , Gázquez José L. , Ayers Paul W. , Vela Alberto
Published: August 2017

An alternative definition of hardness (called the thermodynamic hardness) within the grand canonical ensemble formalism is proposed in terms of the partial derivative of the electronic chemical potential with respect to the thermodynamic chemical potential of the reservoir, keeping the temperature and the external potential constant. This temperature dependent definition may be interpreted as a measure of the propensity of a system to go through a charge transfer process when it interacts with other species, and thus it keeps the philosophy of the original definition. When the derivative is expressed in terms of the three-state ensemble model, in the regime of low temperatures and up to temperatures of chemical interest, one finds that for zero fractional charge, the thermodynamic hardness is proportional to T−1(I−A), where I is the first ionization potential, A is the electron affinity, and T is the temperature. However, the thermodynamic hardness is nearly zero when the fractional charge is different from zero. Thus, through the present definition, one avoids the presence of the Dirac delta function. We show that the chemical hardness defined in this way provides meaningful and discernible information about the hardness properties of a chemical species exhibiting integer or a fractional average number of electrons, and this analysis allowed us to establish a link between the maximum possible value of the hardness here defined, with the minimum softness principle, showing that both principles are related to minimum fractional charge and maximum stability conditions.
Noninvasive hemoglobin measurement using dynamic spectrum
Authors: Yi Xiaoqing , Li Gang , Lin Ling
Published: August 2017

Spectroscopy methods for noninvasive hemoglobin (Hgb) measurement are interfered by individual difference and particular weak signal. In order to address these problems, we have put forward a series of improvement methods based on dynamic spectrum (DS), including instrument design, spectrum extraction algorithm, and modeling approach. The instrument adopts light sources composed of eight laser diodes with the wavelength range from 600 nm to 1100 nm and records photoplethysmography signals at eight wavelengths synchronously. In order to simplify the optical design, we modulate the light sources with orthogonal square waves and design the corresponding demodulation algorithm, instead of adopting a beam-splitting system. A newly designed algorithm named difference accumulation has been proved to be effective in improving the accuracy of dynamic spectrum extraction. 220 subjects are involved in the clinical experiment. An extreme learning machine calibration model between the DS data and the Hgb levels is established. Correlation coefficient and root-mean-square error of prediction sets are 0.8645 and 8.48 g/l, respectively. The results indicate that the Hgb level can be derived by this approach noninvasively with acceptable precision and accuracy. It is expected to achieve a clinic application in the future.
Optical device for thermal diffusivity determination in liquids by reflection of a thermal wave
Authors: Sánchez-Pérez C. , De León-Hernández A. , García-Cadena C.
Published: August 2017

In this work, we present a device for determination of the thermal diffusivity using the oblique reflection of a thermal wave within a solid slab that is in contact with the medium to be characterized. By using the reflection near a critical angle under the assumption that thermal waves obey Snell’s law of refraction with the square root of the thermal diffusivities, the unknown thermal diffusivity is obtained by simple formulae. Experimentally, the sensor response is measured using the photothermal beam deflection technique within a slab that results in a compact device with no contact of the laser probing beam with the sample. We describe the theoretical basis and provide experimental results to validate the proposed method. We determine the thermal diffusivity of tridistilled water and glycerin solutions with an error of less than 0.5%.