bluuebunny/crossref_metadata_2025 huggingface dataset:
Grabbing land legally: A Marxist analysis
Authors: Özsu Umut
Published: February 2019

This article lays the groundwork for a Marxist theory of the international law of land-grabbing. It argues that any comprehensive politico-economic analysis of land-grabbing must also be a politico-economic analysis of the law of land-grabbing. It argues further that Marx’s account of ‘primitive accumulation’ in Capital – an account it presents as an historical explanation of the transition to capitalism as well as a general theory of ‘extra-economic’ force deployed through state power, including, crucially, the power of law – is helpful for developing an analytical framework for understanding the legal facets of land-grabbing. Political economists, rural sociologists, and social and political theorists have argued for and against the applicability of Marx’s theory of ‘primitive accumulation’ to the contemporary wave of global land grabbing. Intriguingly, though, no international lawyers have grappled with the question of whether a specifically Marxist approach to the phenomenon can or should be developed. This article does so, contending that contemporary land-grabbing is unintelligible absent a theory of capitalism, and that the processes whereby capitalism transforms land and labour are unintelligible absent a theory of the periodic waves of legally mediated ‘primitive accumulation’ that propel it forward. The article pays particular attention to the work produced by Olivier De Schutter during his tenure as United Nations Special Rapporteur on the Right to Food.
Seroprevalence of hepatitis E virus in dromedary camels, Bedouins, Muslim Arabs and Jews in Israel, 2009–2017
Authors: Bassal R. , Wax M. , Shirazi R. , Shohat T. , Cohen D. , David D. , Abu-Mouch S. , Abu-Ghanem Y. , Mendelson E. , Ben-Ari Z. , Mor O.
Published: February 2019

Hepatitis E virus (HEV) is an emerging cause of viral hepatitis worldwide. Recently, HEV-7 has been shown to infect camels and humans. We studied HEV seroprevalence in dromedary camels and among Bedouins, Arabs (Muslims, none-Bedouins) and Jews and assessed factors associated with anti-HEV seropositivity. Serum samples from dromedary camels (n = 86) were used to determine camel anti-HEV IgG and HEV RNA positivity. Human samples collected between 2009 and 2016 from >20 years old Bedouins (n = 305), non-Bedouin Arabs (n = 320) and Jews (n = 195), were randomly selected using an age-stratified sampling design. Human HEV IgG levels were determined using Wantai IgG ELISA assay. Of the samples obtained from camels, 68.6% were anti-HEV positive. Among the human populations, Bedouins and non-Bedouin Arabs had a significantly higher prevalence of HEV antibodies (21.6% and 15.0%, respectively) compared with the Jewish population (3.1%). Seropositivity increased significantly with age in all human populations, reaching 47.6% and 34.8% among ⩾40 years old, in Bedouins and non-Bedouin Arabs, respectively. The high seropositivity in camels and in ⩾40 years old Bedouins and non-Bedouin Arabs suggests that HEV is endemic in Israel. The low HEV seroprevalence in Jews could be attributed to higher socio-economic status.
Syndromic surveillance: two decades experience of sustainable systems – its people not just data!
Authors: Smith Gillian E. , Elliot Alex J. , Lake Iain , Edeghere Obaghe , Morbey Roger , Catchpole Mike , Heymann David L. , Hawker Jeremy , Ibbotson Sue , McCloskey Brian , Pebody Richard ,   Public Health England Real-time Syndromic Surveillance Team
Published: February 2019

Syndromic surveillance is a form of surveillance that generates information for public health action by collecting, analysing and interpreting routine health-related data on symptoms and clinical signs reported by patients and clinicians rather than being based on microbiologically or clinically confirmed cases. In England, a suite of national real-time syndromic surveillance systems (SSS) have been developed over the last 20 years, utilising data from a variety of health care settings (a telehealth triage system, general practice and emergency departments). The real-time systems in England have been used for early detection (e.g. seasonal influenza), for situational awareness (e.g. describing the size and demographics of the impact of a heatwave) and for reassurance of lack of impact on population health of mass gatherings (e.g. the London 2012 Olympic and Paralympic Games).We highlight the lessons learnt from running SSS, for nearly two decades, and propose questions and issues still to be addressed. We feel that syndromic surveillance is an example of the use of ‘big data’, but contend that the focus for sustainable and useful systems should be on the added value of such systems and the importance of people working together to maximise the value for the public health of syndromic surveillance services.
Introduction of Ebola virus into a remote border district of Sierra Leone, 2014: use of field epidemiology and RNA sequencing to describe chains of transmission
Authors: DeSilva M. B. , Styles T. , Basler C. , Moses F. L. , Husain F. , Reichler M. , Whitmer S. , McAuley J. , Belay E. , Friedman M. , Muoghalu I. S. , Swaray P. , Ströher U. , Redd J. T.
Published: February 2019

In early October 2014, 7 months after the 2014–2015 Ebola epidemic in West Africa began, a cluster of reported deaths in Koinadugu, a remote district of Sierra Leone, was the first evidence of Ebola virus disease (Ebola) in the district. Prior to this event, geographic isolation was thought to have prevented the introduction of Ebola to this area. We describe our initial investigation of this cluster of deaths and subsequent public health actions after Ebola was confirmed, and present challenges to our investigation and methods of overcoming them. We present a transmission tree and results of whole genome sequencing of selected isolates to identify the source of infection in Koinadugu and demonstrate transmission between its villages. Koinadugu's experience highlights the danger of assuming that remote location and geographic isolation can prevent the spread of Ebola, but also demonstrates how deployment of rapid field response teams can help limit spread once Ebola is detected.
Are food exposures obtained through commercial market panels representative of the general population? Implications for outbreak investigations
Authors: Inns T. , Curtis D. , Crook P. , Vivancos R. , Gardiner D. , McCarthy N. , Mook P.
Published: February 2019

Current methods of control recruitment for case-control studies can be slow (a particular issue for outbreak investigations), resource-intensive and subject to a range of biases. Commercial market panels are a potential source of rapidly recruited controls. Our study evaluated food exposure data from these panel controls, compared with an established reference dataset. Market panel data were collected from two companies using retrospective internet-based surveys; these were compared with reference data from the National Diet and Nutrition Survey (NDNS). We used logistic regression to calculate adjusted odds ratios to compare exposure to each of the 71 food items between the market panel and NDNS participants. We compared 2103 panel controls with 2696 reference participants. Adjusted for socio-demographic factors, exposure to 90% of foods was statistically different between both panels and the reference data. However, these differences were likely to be of limited practical importance for 89% of Panel A foods and 79% of Panel B foods. Market panel food exposures were comparable with reference data for common food exposures but more likely to be different for uncommon exposures. This approach should be considered for outbreak investigation, in conjunction with other considerations such as population at risk, timeliness of response and study resources.
USER COSTS, THE FINANCIAL FIRM, AND MONETARY AND REGULATORY POLICY
Authors: Isakin Maksim , Serletis Apostolos
Published: February 2019

We investigate how key monetary policy instruments and financial regulation affect the banking firm. We take the user-cost approach to the construction of prices for financial services and use quarterly data on the U.S. commercial banking sector, over the period from 1992 to 2016, obtained from the Federal Deposit Insurance Corporation. We use the symmetric generalized Barnett variable profit function to derive demands for and supplies of monetary and nonmonetary goods and provide evidence consistent with neoclassical microeconomic theory. We find that the compensated price elasticities of banking technology are small in magnitude. Yet a hypothetical policy experiment shows that even small changes in the holding costs of financial goods can result in significant changes in user costs and the quantities demanded and supplied.
Objective assessment of compliance with a state-wide school food-service policy via menu audits
Authors: Myers Gael , Sauzier Megan , Ferguson Amanda , Pettigrew Simone
Published: February 2019

Objective

The Healthy Food and Drink Policy was implemented in Western Australian government schools in 2007. The aim of the present study was to assess the compliance of Western Australian school canteen menus with the policy a decade after its introduction.

Design

The traffic-light system that underpins the Healthy Food and Drink Policy categorises foods and drinks into three groups: ‘green’ healthy items, ‘amber’ items that should be selected carefully and ‘red’ items that lack nutritional value. Canteen menus were collected online and each menu item was coded as a green, amber or red choice.

Setting

Western Australia.

Participants

Online canteen menus from 136 primary and secondary government schools.

Results

The majority of audited school menus met policy requirements to include ≥60 % green items (84 %) and ≤40 % amber items (90 %), but only 52 % completely excluded red items. Overall, approximately half (48 %) of school canteen menus met all three traffic-light targets. On average, 70 % of the menu items were green, 28 % were amber and 2 % were red. Primary-school canteen menus were more likely than those from secondary schools to meet the requirements of the policy.

Conclusions

While the sampled Western Australian government school canteen menus were highly compliant with most of the requirements of the Healthy Food and Drink Policy, many offered red foods and/or drinks. Providing all schools with further education about identifying red items and offering additional services to secondary schools may help improve compliance rates.
BELNAP–DUNN MODAL LOGICS: TRUTH CONSTANTS VS. TRUTH VALUES
Authors: ODINTSOV SERGEI P. , SPERANSKI STANISLAV O.
Published: February 2019

We shall be concerned with the modal logic BK—which is based on the Belnap–Dunn four-valued matrix, and can be viewed as being obtained from the least normal modal logic K by adding ‘strong negation’. Though all four values ‘truth’, ‘falsity’, ‘neither’ and ‘both’ are employed in its Kripke semantics, only the first two are expressible as terms. We show that expanding the original language of BK to include constants for ‘neither’ or/and ‘both’ leads to quite unexpected results. To be more precise, adding one of these constants has the effect of eliminating the respective value at the level of BK-extensions. In particular, if one adds both of these, then the corresponding lattice of extensions turns out to be isomorphic to that of ordinary normal modal logics.
A streamlined drain-lag model for GaN HEMTs based on pulsed S-parameter measurements
Authors: Luo Peng , Schnieder Frank , Bengtsson Olof , Vadalà Valeria , Raffo Antonio , Heinrich Wolfgang , Rudolph Matthias
Published: February 2019

Accurately and efficiently modeling the drain-lag effects is crucial in nonlinear large-signal modeling for Gallium Nitride high electron mobility transistors. In this paper, a simplified yet accurate drain-lag model based on an industry standard large-signal model, i.e., the Chalmers (Angelov) model, extracted by means of pulsed S-parameter measurements, is presented. Instead of a complex nonlinear drain-lag description, only four constant parameters of the proposed drain-lag model need to be determined to accurately describe the large impacts of the drain-lag effects, e.g., drain-source current slump, typical kink observed in pulsed IV curves, and degradation of the output power. The extraction procedure of the parameters is based on pulsed S-parameter measurements, which allow to freeze traps and isolate the trapping effects from self-heating. It is also shown that the model can very accurately predict the load pull performance over a wide range of drain bias voltages. Finally, the large-signal network analyzer measurements at low frequency are used to further verify the proposed drain-lag model in the prediction of the output current in time domain under large-signal condition.
Predictive Modeling With Psychological Panel Data
Authors: Pargent Florian , Albert-von der Gönna Johannes
Published: February 2019

Abstract. Longitudinal panels include several thousand participants and variables. Traditionally, psychologists analyze only a few variables – partly because common unregularized linear models perform poorly when the number of variables ( p) approaches the number of observations ( N). Predictive modeling methods can be used when N [Formula: see text]  p situations arise in psychological research. We illustrate these techniques on exemplary variables from the German GESIS Panel, while describing the choice of preprocessing, model classes, resampling techniques, hyperparameter tuning, and performance measures. In analyses with about 2,000 subjects and variables each, we predict panelists’ gender, sick days, an evaluation of US President Trump, income, life satisfaction, and sleep satisfaction. Elastic net and random forest models were compared to dummy predictions in benchmark experiments. While good performance was achieved, the linear elastic net performed similar to the nonlinear random forest. Elastic nets were refitted to extract the ten most important predictors. Their interpretation validates our approach, and further modeling options are discussed. Code can be found at https://osf.io/zpse3/
Replicability of Machine Learning Models in the Social Sciences
Authors: Vijayakumar Ranjith , Cheung Mike W.-L.
Published: February 2019

Abstract. Machine learning tools are increasingly used in social sciences and policy fields due to their increase in predictive accuracy. However, little research has been done on how well the models of machine learning methods replicate across samples. We compare machine learning methods with regression on the replicability of variable selection, along with predictive accuracy, using an empirical dataset as well as simulated data with additive, interaction, and non-linear squared terms added as predictors. Methods analyzed include support vector machines (SVM), random forests (RF), multivariate adaptive regression splines (MARS), and the regularized regression variants, least absolute shrinkage and selection operator (LASSO), and elastic net. In simulations with additive and linear interactions, machine learning methods performed similarly to regression in replicating predictors; they also performed mostly equal or below regression on measures of predictive accuracy. In simulations with square terms, machine learning methods SVM, RF, and MARS improved predictive accuracy and replicated predictors better than regression. Thus, in simulated datasets, the gap between machine learning methods and regression on predictive measures foreshadowed the gap in variable selection. In replications on the empirical dataset, however, improved prediction by machine learning methods was not accompanied by a visible improvement in replicability in variable selection. This disparity is explained by the overall explanatory power of the models. When predictors have small effects and noise predominates, improved global measures of prediction in a sample by machine learning methods may not lead to the robust selection of predictors; thus, in the presence of weak predictors and noise, regression remains a useful tool for model building and replication.
The Geomorphology, Structure, and Lava Flow Dynamics of Peralkaline Rift Volcanoes From High‐Resolution Digital Elevation Models
Authors: Hunt Jonathan A. , Pyle David M. , Mather Tamsin A.
Published: February 2019

Detailed topographic data from volcanoes can yield key insights into the controls on volcanic activity as well as hazards. High‐resolution digital elevation models generated from remote sensing data enable comparison of the geomorphology and structure of large and inaccessible volcanoes. We present new topographic data for three peralkaline volcanoes in the Main Ethiopian Rift (Fentale, Corbetti, and Gedemsa) and one volcano in the Afar Rift (Dabbahu), combined with field observations, reveal previously unidentified post‐caldera deposits and craters. Vent and crater locations are aligned with rift‐parallel faults and also with rift‐cutting structures in a variety of orientations. Caldera shape is controlled by interaction with these structures. The relative frequency and type of eruption varies greatly between these volcanoes over the past 150 kyr. Gedemsa is now largely inactive; Fentale hosts deposits from many small volume eruptions (<0.1 km3); while Corbetti has produced several large eruptions (~0.4–0.5 km3). Morphometry of peralkaline rhyolite deposits at Corbetti and Fentale, including ogives and levees, provides constraints on rheology. Emplacement viscosities of ~108–1011 Pa s at Fentale are similar to or lower than calc‐alkaline rhyolites and consistent with experimental and theoretical studies. The observations presented here have significant implications for hazard assessment in the Ethiopian rift and highlight the importance of structural features in controlling the location, magnitude, and style of volcanic activity in the Main Ethiopian Rift.
A New Ocean SAR Cross‐Spectral Parameter: Definition and Directional Property Using the Global Sentinel‐1 Measurements
Authors: Li Huimin , Chapron Bertrand , Mouche Alexis , Stopa Justin E.
Published: February 2019

Space‐borne synthetic aperture radar (SAR) measurements have already been proven to be invaluable in detecting and quantifying properties of ocean swell systems. With the improved spatial resolution, Sentinel‐1 wave mode measurements can further be extended toward shorter‐scale waves, that is, within the surface wave equilibrium range. In this study, a new parameter is derived from filtering SAR image cross‐spectra around range‐traveling intermediate wind waves (wavelengths 15–20 m). This parameter captures both the radar cross‐section variability and its time evolution. Given the dependence of intermediate waves on local wind field, this parameter is statistically documented to confirm its sensitivity to both wind speed and wind direction. Comparable to Doppler estimate, the signed parameter can be used to reduce the wind direction ambiguity in the inversion of high‐resolution wind fields from SAR imagery. In addition, under complex environmental situations over a polar low event, this parameter is expected to better capture the dynamics of the surface wind. Globally, our analysis demonstrates regional and seasonal variations of this parameter, associated with those of wind/wave patterns. In particular, its directionality reveals the seasonal migration of intertropical convergence zone. This parameter is valuable to various further applications, for example, to help develop wind retrieval scheme from SAR measurements or to map space‐time variability of ocean waves at various wavelengths.
Asteroid Mission Attempts Touchdown, Sample Grab
Authors: Cartier Kimberly
Published: February 2019

Hayabusa2 will fire a metal bullet into the asteroid surface to eject material that will then be collected. The mission will return the samples to Earth in late 2020.
Metabolic regulation of the maize rhizobiome by benzoxazinoids
Authors: Cotton T E Anne , Pétriacq Pierre , Cameron Duncan D , Meselmani Moaed Al , Schwarzenbacher Roland , Rolfe Stephen A , Ton Jurriaan
Published: February 2019

The rhizobiome is an important regulator of plant growth and health. Plants shape their rhizobiome communities through production and release of primary and secondary root metabolites. Benzoxazinoids (BXs) are common tryptophan-derived secondary metabolites in grasses that regulate belowground and aboveground biotic interactions. In addition to their biocidal activity, BXs can regulate plant–biotic interactions as semiochemicals or within-plant defence signals. However, the full extent and mechanisms by which BXs shape the root-associated microbiome has remained largely unexplored. Here, we have taken a global approach to examine the regulatory activity of BXs on the maize root metabolome and associated bacterial and fungal communities. Using untargeted mass spectrometry analysis in combination with prokaryotic and fungal amplicon sequencing, we compared the impacts of three genetic mutations in different steps in the BX pathway. We show that BXs regulate global root metabolism and concurrently influence the rhizobiome in a root type-dependent manner. Correlation analysis between BX-controlled root metabolites and bacterial taxa suggested a dominant role for BX-dependent metabolites, particularly flavonoids, in constraining a range of soil microbial taxa, while stimulating methylophilic bacteria. Our study supports a multilateral model by which BXs control root–microbe interactions via a global regulatory function in root secondary metabolism.
Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477
Authors: Mallick David J. , Soderquist Ryan S. , Bates Darcy , Eastman Alan
Published: February 2019

Targeting anti-apoptotic BCL2 family proteins has become an attractive therapeutic strategy for many cancers, and the BCL2-selective inhibitor ABT-199 (venetoclax) has obtained clinical success. However, MCL1 can promote drug resistance and overall cancer cell survival. Thus, there is a critical need to develop an effective drug that antagonizes MCL1. However, most putative MCL1 inhibitors have been misclassified as they fail to directly inhibit MCL1 in cells, but rather induce the pro-apoptotic protein NOXA. We have investigated three putative MCL1 inhibitors: MIM1, UMI-77, and A-1210477. All three compounds were developed in cell-free assays and then found to be cytotoxic, and hence assumed to directly target MCL1 in cells. Here, we investigated whether these compounds directly inhibit MCL1 or inhibit MCL1 indirectly through the induction of NOXA. Both MIM1- and UMI-77-induced NOXA through the unfolded protein response pathway, and sensitized leukemia cells to ABT-199; this cytotoxicity was dependent on NOXA suggesting that these compounds do not directly target MCL1. A-1210477 was the only compound that did not induce NOXA, but it still sensitized cells to ABT-199. A-1210477 induced accumulation of MCL1 protein consistent with it binding and preventing MCL1 degradation. However, at concentrations used in several prior studies, A-1210477 also induced cytochrome c release, caspase activation, and apoptosis in a BAX/BAK-independent manner. Furthermore, the release of cytochrome c occurred without loss of mitochondrial membrane potential. This apoptosis was extremely rapid, sometimes occurring within 0.5–1 h. Hence, we have identified a novel mechanism of apoptosis that circumvents the known mechanisms of cytochrome c release. It remains to be determined whether these unexpected mechanisms of action of putative BH3 mimetics will have therapeutic potential.
circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA
Authors: Zhang Jia-xiang , Lu Jian , Xie Hui , Wang Da-peng , Ni Huan-er , Zhu Yong , Ren Le-hao , Meng Xiao-xiao , Wang Rui-lan
Published: February 2019

Myofibroblasts predominantly emerging through fibroblast-to-myofibroblast transition (FMT) are considered to be the key collagen-producing cells in pulmonary fibrosis. Circular RNAs (circRNAs) are important players involved in many biological processes. circHIPK3 has been identified as the one of the most abundant circRNAs in human lung. In this study, we characterized the role of circHIPK3 in pulmonary fibrosis. We revealed that circHIPK3 is upregulated in bleomycin-induced pulmonary fibrosis mice model, FMT-derived myofibroblasts. circHIPK3 silencing can ameliorate FMT and suppress fibroblast proliferation in vivo and vitro. Fundamentally, circHIPK3 regulates FMT by functioning as an endogenous miR-338-3p sponge and inhibit miR-338-3p activity, thereby leading to increased SOX4 and COL1A1 expression. Moreover, dysregulated circHIPK3 expression was detected in the clinical samples of patients with idiopathic pulmonary fibrosis. Intervention of circHIPK3 may represent a promising therapy for pulmonary fibrosis.
On the predictability of infectious disease outbreaks
Authors: Scarpino Samuel V. , Petri Giovanni
Published: February 2019

Infectious disease outbreaks recapitulate biology: they emerge from the multi-level interaction of hosts, pathogens, and environment. Therefore, outbreak forecasting requires an integrative approach to modeling. While specific components of outbreaks are predictable, it remains unclear whether fundamental limits to outbreak prediction exist. Here, adopting permutation entropy as a model independent measure of predictability, we study the predictability of a diverse collection of outbreaks and identify a fundamental entropy barrier for disease time series forecasting. However, this barrier is often beyond the time scale of single outbreaks, implying prediction is likely to succeed. We show that forecast horizons vary by disease and that both shifting model structures and social network heterogeneity are likely mechanisms for differences in predictability. Our results highlight the importance of embracing dynamic modeling approaches, suggest challenges for performing model selection across long time series, and may relate more broadly to the predictability of complex adaptive systems.
Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation
Authors: Cabré Gisela , Garrido-Charles Aida , Moreno Miquel , Bosch Miquel , Porta-de-la-Riva Montserrat , Krieg Michael , Gascón-Moya Marta , Camarero Núria , Gelabert Ricard , Lluch José M. , Busqué Félix , Hernando Jordi , Gorostiza Pau , Alibés Ramon
Published: February 2019

Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate individual neurons with three-dimensional precision has been hampered by firstly, the low efficacy and reliability of NIR-induced azobenzene photoisomerization compared to one-photon excitation, and secondly, the short cis state lifetime of the two-photon responsive azo switches. Here we report the rational design based on theoretical calculations and the synthesis of azobenzene photoswitches endowed with both high two-photon absorption cross section and slow thermal back-isomerization. These compounds provide optimized and sustained two-photon neuronal stimulation both in light-scattering brain tissue and in Caenorhabditis elegans nematodes, displaying photoresponse intensities that are comparable to those achieved under one-photon excitation. This finding opens the way to use both genetically targeted and pharmacologically selective azobenzene photoswitches to dissect intact neuronal circuits in three dimensions.
Self- regeneration of Au/CeO2 based catalysts with enhanced activity and ultra-stability for acetylene hydrochlorination
Authors: Ye Lin , Duan Xinping , Wu Simson , Wu Tai-Sing , Zhao Yuxin , Robertson Alex W. , Chou Hung-Lung , Zheng Jianwei , Ayvalı Tuğçe , Day Sarah , Tang Chiu , Soo Yun-Liang , Yuan Youzhu , Tsang Shik Chi Edman
Published: February 2019

Replacement of Hg with non-toxic Au based catalysts for industrial hydrochlorination of acetylene to vinyl chloride is urgently required. However Au catalysts suffer from progressive deactivation caused by auto-reduction of Au(I) and Au(III) active sites and irreversible aggregation of Au(0) inactive sites. Here we show from synchrotron X-ray absorption, STEM imaging and DFT modelling that the availability of ceria(110) surface renders Au(0)/Au(I) as active pairs. Thus, Au(0) is directly involved in the catalysis. Owing to the strong mediating properties of Ce(IV)/Ce(III) with one electron complementary redox coupling reactions, the ceria promotion to Au catalysts gives enhanced activity and stability. Total pre-reduction of Au species to inactive Au nanoparticles of Au/CeO2&AC when placed in a C2H2/HCl stream can also rapidly rejuvenate. This is dramatically achieved by re-dispersing the Au particles to Au(0) atoms and oxidising to Au(I) entities, whereas Au/AC does not recover from the deactivation.
Uncovering and tailoring hidden Rashba spin–orbit splitting in centrosymmetric crystals
Authors: Yuan Linding , Liu Qihang , Zhang Xiuwen , Luo Jun-Wei , Li Shu-Shen , Zunger Alex
Published: February 2019

Hidden Rashba and Dresselhaus spin splittings in centrosymmetric crystals with subunits/sectors having non-centrosymmetric symmetries (the R-2 and D-2 effects) have been predicted theoretically and then observed experimentally, but the microscopic mechanism remains unclear. Here we demonstrate that the spin splitting in the R-2 effect is enforced by specific symmetries, such as non-symmorphic symmetry in the present example, which ensures that the pertinent spin wavefunctions segregate spatially on just one of the two inversion-partner sectors and thus avoid compensation. We further show that the effective Hamiltonian for the conventional Rashba (R-1) effect is also applicable for the R-2 effect, but applying a symmetry-breaking electric field to a R-2 compound produces a different spin-splitting pattern than applying a field to a trivial, non-R-2, centrosymmetric compound. This finding establishes a common fundamental source for the R-1 effect and the R-2 effect, both originating from local sector symmetries rather than from the global crystal symmetry per se.
Copper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay
Authors: Shan Xiang-Huan , Zheng Hong-Xing , Yang Bo , Tie Lin , Fu Jia-Le , Qu Jian-Ping , Kang Yan-Biao
Published: February 2019

Base-promoted C-H cleavage without transition metals opens a practical alternative for the one based on noble metals or radical initiators. The resulting carbanion can pass through radical addition to unsaturated bonds like C-N or C-C triple bonds, in which stoichiometric oxidants are needed. When in situ C-H cleavage meets catalytic carbanion-radical relay, it turns to be challenging but has not been accomplished yet. Here we report the combination of base-promoted benzylic C-H cleavage and copper-catalyzed carbanion-radical redox relay. Catalytic amount of naturally abundant and inexpensive copper salt, such as copper(II) sulfate, is used for anion-radical redox relay without any external oxidant. By avoiding using N-O/N-N homolysis or radical initiators to generate iminyl radicals, this strategy realizes modular synthesis of N-H indoles and analogs from abundant feedstocks, such as toluene and nitrile derivatives, and also enables rapid synthesis of large scale pharmaceuticals.
Spontaneous rotation can stabilise ordered chiral active fluids
Authors: Maitra Ananyo , Lenz Martin
Published: February 2019

Active hydrodynamic theories are a powerful tool to study the emergent ordered phases of internally driven particles such as bird flocks, bacterial suspension and their artificial analogues. While theories of orientationally ordered phases are by now well established, the effect of chirality on these phases is much less studied. In this paper, we present a complete dynamical theory of orientationally ordered chiral particles in two-dimensional incompressible systems. We show that phase-coherent states of rotating chiral particles are remarkably stable in both momentum-conserved and non-conserved systems in contrast to their non-rotating counterparts. Furthermore, defect separation—which drives chaotic flows in non-rotating active fluids—is suppressed by intrinsic rotation of chiral active particles. We thus establish chirality as a source of dramatic stabilisation in active systems, which could be key in interpreting the collective behaviors of some biological tissues, cytoskeletal systems and collections of bacteria.
Photoacoustic transfection of DNA encoding GFP
Authors: Silva Alexandre D. , Serpa Carlos , Arnaut Luis G.
Published: February 2019

Photoacoustic transfection consists in the use of photoacoustic waves, generated in the thermoelastic expansion of a confined material absorbing a short pulse of a laser, to produce temporary mechanical deformations of the cell membrane and facilitate the delivery of plasmid DNA into cells. We show that high stress gradients, produced when picosecond laser pulses with a fluence of 100 mJ/cm2 are absorbed by piezophotonic materials, enable transfection of a plasmid DNA encoding Green Fluorescent Protein (gWizGFP, 3.74 MDa) in COS-7 monkey fibroblast cells with an efficiency of 5% at 20 °C, in 10 minutes. We did not observe significant cytotoxicity under these conditions. Photoacoustic transfection is scalable, affordable, enables nuclear localization and the dosage is easily controlled by the laser parameters.
Photoinitiated Marangoni flow morphing in a liquid crystalline polymer film directed by super-inkjet printing patterns
Authors: Kitamura Issei , Oishi Kazuaki , Hara Mitsuo , Nagano Shusaku , Seki Takahiro
Published: February 2019

Slight contaminations existing in a material lead to substantial defects in applied paint. Herein, we propose a strategy to convert this nuisance to a technologically useful process by using an azobenzene-containing side chain liquid crystalline (SCLCP) polymer. This method allows for a developer-free phototriggered surface fabrication. The mass migration is initiated by UV-light irradiation and directed by super-inkjet printed patterns using another polymer on the SCLCP film surface. UV irradiation results in a liquid crystal-to-isotropic phase transition, and this phase change immediately initiates a mass migration to form crater or trench structures due to the surface tension instability known as Marangoni flow. The transferred volume of the film reaches approximately 440-fold that of the polymer ink, and therefore, the printed ink pattern acts as a latent image towards the amplification of surface morphing. This printing-aided photoprocess for surface inscription is expected to provide a new platform of polymer microfabrication.
Within-Host Genomic Diversity of Candida albicans in Healthy Carriers
Authors: Sitterlé Emilie , Maufrais Corinne , Sertour Natacha , Palayret Matthieu , d’Enfert Christophe , Bougnoux Marie-Elisabeth
Published: February 2019

Genomic variations in Candida albicans, a major fungal pathogen of humans, have been observed upon exposure of this yeast to different stresses and experimental infections, possibly contributing to subsequent adaptation to these stress conditions. Yet, little is known about the extent of genomic diversity that is associated with commensalism, the predominant lifestyle of C. albicans in humans. In this study, we investigated the genetic diversity of C. albicans oral isolates recovered from healthy individuals, using multilocus sequencing typing (MLST) and whole genome sequencing. While MLST revealed occasional differences between isolates collected from a single individual, genome sequencing showed that they differed by numerous single nucleotide polymorphisms, mostly resulting from short-range loss-of-heterozygosity events. These differences were shown to have occurred upon human carriage of C. albicans rather than subsequent in vitro manipulation of the isolates. Thus, C. albicans intra-sample diversity appears common in healthy individuals, higher than that observed using MLST. We propose that diversifying lineages coexist in a single human individual, and this diversity can enable rapid adaptation under stress exposure. These results are crucial for the interpretation of longitudinal studies evaluating the evolution of the C. albicans genome.
Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function
Authors: Tanaka Hiroshi , Mito Akihisa , Hirano Harutoyo , Soh Zu , Nakamura Ryuji , Saeki Noboru , Kawamoto Masashi , Higashi Yukihito , Yoshizumi Masao , Tsuji Toshio
Published: February 2019

This paper proposes an algorithm for estimating the arterial viscosity using cuff pressures and pulse waves measured by an automatic oscillometric sphygmomanometer. A change in the arterial viscosity during the enclosed-zone flow-mediated dilation test is calculated as an index for evaluating the vascular endothelial function %η. In all, 43 individuals participated in this study. After the index %η was calculated, the accuracy of the index %η in distinguishing healthy subjects and subjects at a high risk of arteriosclerosis was tested via a receiving operating characteristic (ROC) analysis. The calculated %η for the healthy participants and those at a high risk of arteriosclerosis was 13.4 ± 55.1% and −32.7 ± 34.0% (mean ± S.D.), respectively. The area under the ROC curve was 0.77. Thus, it was concluded that the proposed method can be used to evaluate the vascular endothelial function.
The circulating form of neprilysin is not a general biomarker for overall survival in treatment-naïve cancer patients
Authors: Pavo Noemi , Arfsten Henrike , Cho Anna , Goliasch Georg , Bartko Philipp E. , Wurm Raphael , Freitag Claudia , Gisslinger Heinz , Kornek Gabriela , Strunk Guido , Raderer Markus , Zielinski Christoph , Hülsmann Martin
Published: February 2019

The transmembrane zink-metalloendopeptidase neprilysin (NEP) is implicated in cardiovascular disease but also tumor biology. The aim of the study was to investigate the relationship of circulating NEP (cNEP) levels with established cardiovascular biomarkers and its effect on overall survival in an unselected cohort of treatment-naïve cancer patients. 555 consecutive cancer patients prior anticancer therapy were enrolled prospectively. NEP levels were determined alongside routine laboratory parameters, established cardiac biomarkers, i.e. NT-proBNP, hsTnT, MR-proANP, MR-proADM, CT-proET-1 and Copeptin, and inflammatory parameters, i.e. CRP, IL-6 and SAA, in venous plasma samples. All-cause mortality was the primary endpoint. cNEP levels of 276 pg/ml (IQR: 0–5981) displayed a weak inverse correlation with age [r = −0.12, p = 0.023] and inflammatory status [r = −0.14, p = 0.007 CRP; r = −0.20, p < 0.001 IL-6 and r = −0.18, p < 0.001 SAA]. cNEP was comparable between different tumor entities and stages and not related to functional parameters of other organ systems as kidney, liver or especially the heart. Moreover, cNEP was not associated with overall survival in the total cohort [adj.HR for ln (cNEP) 1.00, 95% CI: 0.94–1.06, p = 0.887] but in myelodysplatic malignancies [adj.HR for ln (cNEP) 1.27, 95% CI: 1.01–1.61, p = 0.044]. In conclusion, cNEP lacks association with outcome but for myelodysplastic disease. cNEP shows no correlation with established cardiovascular biomarkers related to prognosis, thereby holding a limited potential as a biomarker in cardio-oncology.
The application of Lempel-Ziv and Titchener complexity analysis for equine telemetric electrocardiographic recordings
Authors: Alexeenko Vadim , Fraser James A. , Dolgoborodov Alexey , Bowen Mark , Huang Christopher L.-H. , Marr Celia M. , Jeevaratnam Kamalan
Published: February 2019

The analysis of equine electrocardiographic (ECG) recordings is complicated by the absence of agreed abnormality classification criteria. We explore the applicability of several complexity analysis methods for characterization of non-linear aspects of electrocardiographic recordings. We here show that complexity estimates provided by Lempel-Ziv ’76, Titchener’s T-complexity and Lempel-Ziv ’78 analysis of ECG recordings of healthy Thoroughbred horses are highly dependent on the duration of analysed ECG fragments and the heart rate. The results provide a methodological basis and a feasible reference point for the complexity analysis of equine telemetric ECG recordings that might be applied to automate detection of equine arrhythmias in equine clinical practice.
Bidirectional association between gallstones and renal stones: Two longitudinal follow-up studies using a national sample cohort
Authors: Kim So Young , Song Chang Myeon , Lim Hyun , Lim Man Sup , Bang Woojin , Choi Hyo Geun
Published: February 2019

The present study evaluated the associations between gallstones and renal stones using a national sample cohort of the Korean population. The Korean National Health Insurance Service-National Sample Cohort was collected from 2002 to 2013. We designed two different longitudinal follow-up studies. In study I, we extracted gallstone patients (n = 20,711) and 1:4-matched control I subjects (n = 82,844) and analyzed the occurrence of renal stones. In study II, we extracted renal stone patients (n = 23,615) and 1:4-matched control II subjects (n = 94,460) and analyzed the occurrence of gallstones. Matching was performed for age, sex, income, region of residence, and history of hypertension, diabetes mellitus, and dyslipidemia. Crude and adjusted hazard ratios (HRs) were calculated using a Cox proportional hazards model, and the 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted HR of renal stones was 1.93 (95% CI = 1.75–2.14) in the gallstone group (P < 0.001). The adjusted HR of gallstones was 1.97 (95% CI = 1.81–2.15) in the renal stone group (P < 0.001). The results were consistent in all subgroup analyses. Gallstones increased the risk of renal stones, and renal stones increased the risk of gallstones.
Epistatic interactions of major effect drought QTLs with genetic background loci determine grain yield of rice under drought stress
Authors: Yadav Shailesh , Sandhu Nitika , Majumder Ratna Rani , Dixit Shalabh , Kumar Santosh , Singh S. P. , Mandal N. P. , Das S. P. , Yadaw Ram Baran , Singh Vikas Kumar , Sinha Pallavi , Varshney Rajeev K. , Kumar Arvind
Published: February 2019

Epistatic interactions of QTLs with the genetic background and QTL-QTL interaction plays an important role in the phenotypic performance of introgression lines developed through genomic-assisted breeding (GAB). In this context, NIL pairs developed with various drought QTL (qDTY) combinations in the genetic background of IR64, TDK1-Sub1and Savitri backgrounds were utilized to study the interactions. Multi-season phenotyping of NIL pairs harboring similarqDTYcombinations provided contrasting performance for grain yield under drought (RS) (classified as high and low yielding NILs) but nearly similar performance under non-stress(NS) conditions. Genome wide genotyping data revealed a total of 16, 5 and 6 digenic interactions were detected under RS conditions in low yielding NILs of IR64, TDK1-Sub1and Savitri respectively while no significant interaction was found in high yielding NILs under RS and NS conditions in any of the genetic backgrounds used in this study. It is evident from this study that existence of epistatic interactions between QTLs with genetic background, QTL-QTL interaction and interactions among background markers loci itself on different chromosomes influences the expression of a complex trait such as grain yield under drought. The generated information will be useful in all the GAB program of across the crops for precise breeding.
Parity-time symmetry in coherent asymmetric double quantum wells
Authors: Tian Si-Cong , Wan Ren-Gang , Wang Li-Jie , Shu Shi-Li , Lu Huan-Yu , Zhang Xin , Tong Cun-Zhu , Xiao Min , Wang Li-Jun
Published: February 2019

A coherently prepared asymmetric double semiconductor quantum well (QW) is proposed to realize parity-time (PT) symmetry. By appropriately tuning the laser fields and the pertinent QW parameters, PT-symmetric optical potentials are obtained by three different methods. Such a coherent QW system is reconfigurable and controllable, and it can generate new approaches of theoretically and experimentally studying PT-symmetric phenomena.
Identification of the first endolysin Cell Binding Domain (CBD) targeting Paenibacillus larvae
Authors: Santos Sílvio B. , Oliveira Ana , Melo Luís D. R. , Azeredo Joana
Published: February 2019

Bacteriophage endolysins present enormous biotechnological potentials and have been successfully used to control and detect bacterial pathogens. Endolysins targeting Gram-positive bacteria are modular, displaying a cell binding (CBD) and an enzymatically active domain. The CBD of phage endolysins are recognized by their high specificity and host affinity, characteristics that make them promising diagnostic tools. No CBD able to bind Paenibacillus larvae has been identified so far. P. larvae is a Gram-positive spore forming bacteria that causes the American Foulbrood. This highly contagious infection leads to honeybee larvae sepsis and death, resulting in an adverse impact on pollination and on the beekeeping industry. In this work, the first CBD targeting P. larvae was identified and its core binding sequence was investigated. Moreover, it was shown that the domain is highly specific, targeting exclusively P. larvae cells from all ERIC genotypes. The identification of such a domain represents a step forward for the development of effective methods to detect and control this pathogen.
Electrically Reconfigurable Micromirror Array for Direct Spatial Light Modulation of Terahertz Waves over a Bandwidth Wider Than 1 THz
Authors: Kappa Jan , Sokoluk Dominik , Klingel Steffen , Shemelya Corey , Oesterschulze Egbert , Rahm Marco
Published: February 2019

We report the design, fabrication and experimental investigation of a spectrally wide-band terahertz spatial light modulator (THz-SLM) based on an array of 768 actuatable mirrors with each having a length of 220 μm and a width of 100 μm. A mirror length of several hundred micrometers is required to reduce diffraction from individual mirrors at terahertz frequencies and to increase the pixel-to-pixel modulation contrast of the THz-SLM. By means of spatially selective actuation, we used the mirror array as reconfigurable grating to spatially modulate terahertz waves in a frequency range from 0.97 THz to 2.28 THz. Over the entire frequency band, the modulation contrast was higher than 50% with a peak modulation contrast of 87% at 1.38 THz. For spatial light modulation, almost arbitrary spatial pixel sizes can be realized by grouping of mirrors that are collectively switched as a pixel. For fabrication of the actuatable mirrors, we exploited the intrinsic residual stress in chrome-copper-chrome multi-layers that forces the mirrors into an upstanding position at an inclination angle of 35°. By applying a bias voltage of 37 V, the mirrors were pulled down to the substrate. By hysteretic switching, we were able to spatially modulate terahertz radiation at arbitrary pixel modulation patterns.