bluuebunny/crossref_metadata_2025 huggingface dataset:
How Does Developing Green Agriculture Affect Poverty? Evidence from China’s Prefecture-Level Cities
Authors: Jiang Xingling , Sun Yong , Shen Mou , Tang Lixia
Published: March 2024

Eradicating poverty and improving human well-being are pivotal objectives for achieving global sustainable development. Sustainable agriculture, as a key domain, plays a crucial role in addressing poverty. However, to date, there remains insufficient research on the specific impact of agricultural green development on poverty. To bridge this gap, we utilize panel data from 273 prefecture-level cities in China from 2006 to 2022 to explore how agricultural green development affects poverty based on constructing a regional multidimensional poverty index and an index of green agriculture. Our study reveals that agricultural green development effectively reduces poverty, particularly in regions of deep poverty and the eastern part of China. Further mediating analysis indicates the alleviation of poverty by agricultural green development through the infrastructure, the industrial structure, and the green technology innovation effect. Our findings offer valuable insights for informing policies on agricultural green development and poverty reduction, as well as for improving government resource allocation and strengthening resilience in impoverished areas. By deepening our understanding of the link between green agriculture and poverty, this research significantly contributes to global agricultural sustainability and expedites poverty eradication worldwide.
Morning Glory Flower Detection in Aerial Images Using Semi-Supervised Segmentation with Gaussian Mixture Models
Authors: Valicharla Sruthi Keerthi , Wang Jinge , Li Xin , Gururajan Srikanth , Karimzadeh Roghaiyeh , Park Yong-Lak
Published: March 2024

The invasive morning glory, Ipomoea purpurea (Convolvulaceae), poses a mounting challenge in vineyards by hindering grape harvest and as a secondary host of disease pathogens, necessitating advanced detection and control strategies. This study introduces a novel automated image analysis framework using aerial images obtained from a small fixed-wing unmanned aircraft system (UAS) and an RGB camera for the large-scale detection of I. purpurea flowers. This study aimed to assess the sampling fidelity of aerial detection in comparison with the actual infestation measured by ground validation surveys. The UAS was systematically operated over 16 vineyard plots infested with I. purpurea and another 16 plots without I. purpurea infestation. We used a semi-supervised segmentation model incorporating a Gaussian Mixture Model (GMM) with the Expectation-Maximization algorithm to detect and count I. purpurea flowers. The flower detectability of the GMM was compared with that of conventional K-means methods. The results of this study showed that the GMM detected the presence of I. purpurea flowers in all 16 infested plots with 0% for both type I and type II errors, while the K-means method had 0% and 6.3% for type I and type II errors, respectively. The GMM and K-means methods detected 76% and 65% of the flowers, respectively. These results underscore the effectiveness of the GMM-based segmentation model in accurately detecting and quantifying I. purpurea flowers compared with a conventional approach. This study demonstrated the efficiency of a fixed-wing UAS coupled with automated image analysis for I. purpurea flower detection in vineyards, achieving success without relying on data-driven deep-learning models.
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo
Authors: Zhou Chong , Li Dandan , He Jinxia , Luo Tao , Liu Yiting , Xue Yue , Huang Jian , Zheng Liping , Li Jia
Published: March 2024

Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by the abnormal alteration of hormone levels such as FSH and E2. POI causes infertility, severe daily life disturbances, and long-term health risks. However, the underlying mechanism remains largely unknown. In this study, we found that POI is associated with the cellular senescence of ovarian granulosa cells, and TRIM28 mediates oxidative stress (OS)-induced cellular senescence in granulosa cells. Mechanistically, OS causes a decrease in TRIM28 protein levels in KGN cells. Subsequently, it triggers an increase in the levels of autophagy marker proteins ATG5 and LC3B-II, and the downregulation of P62. Abnormal autophagy induces an increase in the levels of cellular senescence markers γ-H2A.X, P16, and P21, provoking cellular senescence in vitro. The overexpression of ovarian TRIM28 through a microinjection of lentivirus attenuated autophagy, cellular senescence, and follicular atresia in the ovaries of POI mice and improved mouse fertility in vivo. Our study highlights the triggers for POI, where the reduction of TRIM28, which is regulated by reactive oxygen species, causes follicular atresia and POI via triggering autophagy and inducing granulosa cell senescence. Shedding light on TRIM28 may represent a potential intervention strategy for POI.
Anti-Inflammatory Effects of Anthocyanin-Enriched Black Soybean Seed Coat (BSSC) Crude Extract on LPS-Induced Acute Liver Injury in Mice
Authors: Tung Yu-Tang , Tung Chun-Liang , Hsieh Cheng-Chia , Huang Yu-Chen , Li Shiming , Tung Chun-Liang , Wu Jyh-Horng
Published: March 2024

Soybeans rank among the top five globally produced crops. Black soybeans contain anthocyanins in their seed coat, offering strong antioxidant and anti-inflammatory benefits. This study explores the protective effects of black soybean seed coat (BSSC) against acute liver injury (ALI) in mice. Mice pretreated with BSSC crude extract showed reduced liver damage, inflammation, and apoptosis. High doses (300 mg/kg) of the extract decreased levels of proinflammatory cytokines (IL-6, IFN-γ) and increased levels of anti-inflammatory ones (IL-4, IL-10), alongside mitigating liver pathological damage. Additionally, it influenced the Nrf2/HO-1 pathway and reduced levels of apoptosis-related proteins. In vitro, the compounds delphinidin-3-O-glucoside (D3G) and cyanidin-3-O-glucoside (C3G) in BSSC were found to modulate cytokine levels, suggesting their role in ALI protection. The study concludes that BSSC extract, particularly due to D3G and C3G, effectively protects against LPS-induced ALI in mice by inhibiting inflammation, oxidative stress, and apoptosis.
Visualized Hydraulic Fracture Re-Orientation in Directional Hydraulic Fracturing by Laboratory Experiments in Gelatin Samples
Authors: Zhang Hua , Liu Benben , He Qingyuan
Published: March 2024

Directional hydraulic fracturing (DHF) is popular with hydraulic fracturing operations in coal mining to create cave-hard roofs, in which radial initial notches are created around open borehole walls before injecting high-pressurized fluid. Despite extensive field application of DHF, the three-dimensional irregular hydraulic fracture (HF) geometry in DHF remains unclear, and the HF re-orientation mechanism requires comprehensive understanding. Here, we experimentally examined factors affecting HF re-orientation in DHF in transparent gelatin samples with a self-developed experimental device. We found that it is the ratio between the differential stress and gelatin elastic moduls that determines HF re-orientation rather than the absolute magnitudes of these two factors. Both shear failure and tensile failure occur during HF re-orientation. The HF tends to propagate asymmetrically, and the step-like HF geometry is likely to form in gelatin samples with low elastic moduli and under high differential stresses. HF re-orientation is not necessarily a near-borehole effect, and HFs can propagate along the notch direction for longer distances in stiffer gelatin samples under relatively low or moderate differential stresses. Finally, recommendations are provided for the effective utilization of DHF at coal mine sites.
A New Approach for Discontinuity Extraction Based on an Improved Naive Bayes Classifier
Authors: Lu Guangyin , Zhu Xudong , Cao Bei , Li Yani , Tao Chuanyi , Yang Zicheng
Published: March 2024

An increasing number of methods are being used to extract rock discontinuities from 3D point cloud data of rock surfaces. In this paper, a new method for automatic extraction of rock discontinuity based on an improved Naive Bayes classifier is proposed. The method first uses principal component analysis to find the normal vectors of the points, and then generates a certain number of random point sets around the selected training points for training the classifier. The trained, improved Naive Bayes classifier is based on point normal vectors and is able to automatically remove noise points due to various reasons in conjunction with the knee point algorithm, realizing high-precision extraction of the discontinuity sets. Subsequently, the individual discontinuities are segmented using a hierarchical density-based spatial clustering method with noise application. Finally, the PCA algorithm is used to complete the orientation by plane fitting the individual discontinuities. The method was applied in two cases, Kingston and Colorado, and the reliability and advantages of the new method were verified by comparing the results with those of previous research, and the discussion and analysis determined the optimal values of the relevant parameters in the algorithm.
Single-Shot Full Characterization of the Spatial Wavefunction of Light Fields via Stokes Tomography
Authors: Yu Bingshi , Li Chunyu , Jiang Jiaqi , Wu Haijun , Zhao Bo , Rosales-Guzmán Carmelo , Shi Baosen , Zhu Zhihan
Published: March 2024

Since the diffraction behavior of a light field is fully determined by its spatial wavefunction, i.e., its spatial complex amplitude (SCA), full characterization of spatial wavefunction plays a vital role in modern optics from both the fundamental and applied aspects. In this work, we present a novel “complex-amplitude profiler” based on spatial Stokes tomography with the capability to fully determine the SCA of a light field in a single shot with high precision and resolution. The SCA slice observed at any propagation plane provides complete information about the light field, thus allowing us to further retrieve the complete beam structure in the 3D space as well as the exact modal constitution in terms of spatial degrees of freedom. The principle demonstrated here provides an important advancement for the full characterization of light beams with a broad spectrum of potential applications in various areas of optics, especially for the growing field of structured light.
A Strange Result Regarding Some MHD Motions of Generalized Burgers’ Fluids with a Differential Expression of Shear Stress on the Boundary
Authors: Fetecau Constantin , Moroşanu Costică , Akhtar Shehraz
Published: March 2024

In this work, we investigate isothermal MHD motions of a large class of rate type fluids through a porous medium between two infinite horizontal parallel plates when a differential expression of the non-trivial shear stress is prescribed on the boundary. Exact expressions are provided for the dimensionless steady state velocities, shear stresses and Darcy’s resistances. Obtained solutions can be used to find the necessary time to touch the steady state or to bring to light certain characteristics of the fluid motion. Graphical representations showed the fluid moves slower in presence of a magnetic field or porous medium. In addition, contrary to our expectations, the volume flux across a plane orthogonal to the velocity vector per unit width of this plane is zero. Finally, based on a simple remark regarding the governing equations of velocity and shear stress for MHD motions of incompressible generalized Burgers’ fluids between infinite parallel plates, provided were the first exact solutions for MHD motions of these fluids when the two plates apply oscillatory or constant shear stresses to the fluid. This important remark offers the possibility to solve any isothermal MHD motion of these fluids between infinite parallel plates or over an infinite plate when the non-trivial shear stress is prescribed on the boundary. As an application, steady state solutions for MHD motions of same fluids have been developed when a differential expression of the fluid velocity is prescribed on the boundary.
Gravity on a Large Scale—Does It Necessarily Look like It Does on a Small Scale?
Authors: Kijowski Jerzy
Published: March 2024

The notion of a local inertial reference frame is thoroughly analyzed. Dynamics of a field of such frames is derived from the variational principle. It is shown that the resulting theory splits naturally into three sectors, one of which is purely gravitational. Field dynamics in this sector, equivalent to Einstein’s vacuum equations, is obtained unambiguously and admits no ad hoc corrections. The cosmological constant is an essential element of this construction and cannot be removed. It has been shown that the second sector of this theory corresponds to electrodynamics, while the last sector could possibly describe dark matter.
Recent Advances in Thermal Management Strategies for Lithium-Ion Batteries: A Comprehensive Review
Authors: Ortiz Yadyra , Arévalo Paul , Peña Diego , Jurado Francisco
Published: March 2024

Effective thermal management is essential for ensuring the safety, performance, and longevity of lithium-ion batteries across diverse applications, from electric vehicles to energy storage systems. This paper presents a thorough review of thermal management strategies, emphasizing recent advancements and future prospects. The analysis begins with an evaluation of industry-standard practices and their limitations, followed by a detailed examination of single-phase and multi-phase cooling approaches. Successful implementations and challenges are discussed through relevant examples. The exploration extends to innovative materials and structures that augment thermal efficiency, along with advanced sensors and thermal control systems for real-time monitoring. The paper addresses strategies for mitigating the risks of overheating and propagation. Furthermore, it highlights the significance of advanced models and numerical simulations in comprehending long-term thermal degradation. The integration of machine learning algorithms is explored to enhance precision in detecting and predicting thermal issues. The review concludes with an analysis of challenges and solutions in thermal management under extreme conditions, including ultra-fast charging and low temperatures. In summary, this comprehensive review offers insights into current and future strategies for lithium-ion battery thermal management, with a dedicated focus on improving the safety, performance, and durability of these vital energy sources.
Exploring the Antioxidant Properties of Citrus limon (Lemon) Peel Ultrasound Extract after the Cloud Point Extraction Method
Authors: Athanasiadis Vassilis , Chatzimitakos Theodoros , Mantiniotou Martha , Bozinou Eleni , Lalas Stavros I.
Published: March 2024

Each year, a substantial amount of food is discarded around the globe. A significant portion of this waste consists of by-products derived from Citrus fruits such as lemons. The purpose of this research is to examine the polyphenol extraction and the antioxidant ability of lemon peel using cloud point extraction (CPE), a sustainable approach. CPE was conducted using three steps with a 20% w/v concentration of Span 20 as the surfactant, which has a critical micellar concentration of 6.13 × 10−5 mol/L. The pH was set at 7 and a salt concentration of 20% was maintained at 45 °C for 20 min. The subsequent outcomes of the analysis were obtained: total polyphenol content (TPC): 526.32 mg gallic acid equivalents per liter; total flavonoid content (TFC): 90.22 mg rutin equivalents per liter; FRAP, DPPH, and hydrogen peroxide assays: 2.40, 2.68 and 1.03 mmol ascorbic acid equivalents per liter, respectively, and 168.63 mg/L ascorbic acid content. The quantification of the polyphenolic compounds through High-Performance Liquid Chromatography showed that the most abundant compounds in the lemon peels are eriocitrin (159.43 mg/L) and hesperidin (135.21 mg/L). The results indicate that the proposed CPE technique is successful in extracting antioxidant compounds from lemon peels. The generated extracts have the potential to be exploited as dietary additives to enhance human health and can also be utilized for nutraceuticals or pharmaceutical purposes.
Influence of the Stick Grasping in Sprint and Change of Direction Performance in Elite Youth Rink Hockey Players
Authors: Arboix-Alió Jordi , Trabal Guillem , Buscà Bernat , Moreno-Galcerán Dani , de Pablo Bernat , Sarmento Hugo , Vaz Vasco
Published: March 2024

This study aimed to investigate the influence of stick grasping on the performance of elite youth rink hockey players in 10 m linear sprints and 180° change of direction (COD) tasks. Forty-nine rink hockey players (age = 18.40 ± 2.12 year; body mass = 73.52 ± 6.02 kg; height = 1.82 ± 0.07 m; BMI = 23.61 ± 1.69; sports experience = 6.42 ± 1.41 years; 4.89 ± 0.68 years’ post-peak height velocity) participated in this cross-sectional study. Measurements included 10 m sprint time and COD 180° performance with and without stick grasping. Results revealed non-significant differences when carrying a stick in the 10 m linear sprint (1.90 s ± 0.08 with stick vs. 1.89 s ± 0.08 without stick; p = 0.71; d = 0.05), neither did COD 180° for the left limb (2.75s ± 0.11 with stick vs. 2.76 s ± 0.11 without stick; p = 0.91; d = 0.02). However, for the right limb, significantly better performance in COD 180° was found when players held the stick (2.72 s ± 0.11 with stick vs. 2.75 s ± 0.09 without stick; p = 0.03; d = 0.32). These findings imply that the distinctive biomechanics and requirements of rink hockey, especially the lateral movements inherent in skating, might alleviate the negative impacts associated with implement grasping observed in other sports. This study highlights that stick grasping did not hinder COD ability and may even have a facilitating effect on certain movements, emphasizing the importance of considering sport-specific biomechanics in rink hockey performance analysis.
Computational and Experimental Approaches Exploring the Role of Hesperetin in Improving Autophagy in Rat Diabetic Retinopathy
Authors: Alshaman Reem , Kolieb Eman , El-Sayed Rehab M. , Gouda Sahar Galal , Alattar Abdullah , Zaitone Sawsan A. , Abdelmaogood Asmaa K. K. , Elabbasy Lamiaa M. , Eltrawy Amira H. , Sayd Fai Yahya , Mokhtar Hatem I. , Wafa Esam Ghanem Abu El , Ahmed Esam Sayed , Liang Dong , Ali Dina A.
Published: March 2024

Diabetic retinopathy (DR) is a debilitating diabetic disorder of the retinal microvasculature and the main cause of avoidable blindness in old people. Hesperetin is a plant flavanone largely abundant in citrus species with neuroprotective properties in animal models. This study aimed to explore the neuroprotective and autophagy-enhancing effect of hesperetin in rats with DR. Twenty-four male rats were utilized and allocated to groups: (i) the vehicle group, (ii) DR group and (iii–iv) the DR + hesperetin (50 and 100 mg/kg) groups. Treatment with hesperetin continued for 6 weeks. After the rats were euthanized, their eyes were dissected to detect the biochemical and histological changes in the retinas. Quantification of autophagy markers, beclin 1/LC3/p62, and inflammation markers was performed. Histopathologic changes were investigated after staining with hematoxylin and eosin and periodic acid–Schiff (PAS). Results demonstrated that hesperetin decreased the PAS staining in diabetic rats and attenuated histopathological changes and restored retinal organization and thickness of layers in hematoxylin and eosin staining. Moreover, hesperetin reduced the level of mRNA expression for TNF-α (4.9-fold), IL-1β (4.15-fold), IL-6 (4.6-fold) and NFκB (5.2-fold), as well as the protein level. This was accompanied by induction of autophagy proteins, beclin 1 and LC3-II. Our results afford evidence that hesperetin is effective in alleviating the pathology of DR via suppressing the inflammatory burden and induction of autophagy. After extensive clinical examinations, hesperetin may prove to be a useful option for treatment of DR.
Red Blood Cell Adenylate Energetics Is Related to Endothelial and Microvascular Function in Long COVID
Authors: Romanowska-Kocejko Marzena , Jędrzejewska Agata , Braczko Alicja , Stawarska Klaudia , Król Oliwia , Frańczak Marika , Harasim Gabriela , Smoleński Ryszard T. , Hellmann Marcin , Kutryb-Zając Barbara
Published: March 2024

Adenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial and microvascular functions. Recently, it has been shown that infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) might lead to morphological and metabolic alterations in erythrocytes in both mild and severe cases of coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on the nucleotide energetics of RBCs nor about the potential contribution of nucleotide metabolism to the long COVID syndrome. This study aimed to analyze the levels of adenine nucleotides in RBCs isolated from patients 12 weeks after mild SARS-CoV-2 infection who suffered from long COVID symptoms and to relate them with the endothelial and microvascular function parameters as well as the rate of peripheral tissue oxygen supply. Although the absolute quantities of adenine nucleotides in RBCs were rather slightly changed in long COVID individuals, many parameters related to the endothelial and microcirculatory function showed significant correlations with RBC adenosine triphosphate (ATP) and total adenine nucleotide (TAN) concentration. A particularly strong relationship was observed between ATP in RBCs and the serum ratio of arginine to asymmetric dimethylarginine—an indicator of endothelial function. Consistently, a positive correlation was also observed between the ATP/ADP ratio and diminished reactive hyperemic response in long COVID patients, assessed by the flow-mediated skin fluorescence (FMSF) technique, which reflected decreased vascular nitric oxide bioavailability. In addition, we have shown that patients after COVID-19 have significantly impaired ischemic response parameters (IR max and IR index), examined by FMSF, which revealed diminished residual bioavailability of oxygen in epidermal keratinocytes after brachial artery occlusion. These ischemic response parameters revealed a strong positive correlation with the RBC ATP/ADP ratio, confirming a key role of RBC bioenergetics in peripheral tissue oxygen supply. Taken together, the outcomes of this study indicate that dysregulation of metabolic processes in erythrocytes with the co-occurring endothelial and microvascular dysfunction is associated with diminished intracellular oxygen delivery, which may partly explain long COVID-specific symptoms such as physical impairment and fatigue.
Revolutionizing Kidney Transplantation: Connecting Machine Learning and Artificial Intelligence with Next-Generation Healthcare—From Algorithms to Allografts
Authors: Ramalhete Luís , Almeida Paula , Ferreira Raquel , Abade Olga , Teixeira Cristiana , Araújo Rúben
Published: March 2024

This review explores the integration of artificial intelligence (AI) and machine learning (ML) into kidney transplantation (KT), set against the backdrop of a significant donor organ shortage and the evolution of ‘Next-Generation Healthcare’. Its purpose is to evaluate how AI and ML can enhance the transplantation process, from donor selection to postoperative patient care. Our methodology involved a comprehensive review of current research, focusing on the application of AI and ML in various stages of KT. This included an analysis of donor–recipient matching, predictive modeling, and the improvement in postoperative care. The results indicated that AI and ML significantly improve the efficiency and success rates of KT. They aid in better donor–recipient matching, reduce organ rejection, and enhance postoperative monitoring and patient care. Predictive modeling, based on extensive data analysis, has been particularly effective in identifying suitable organ matches and anticipating postoperative complications. In conclusion, this review discusses the transformative impact of AI and ML in KT, offering more precise, personalized, and effective healthcare solutions. Their integration into this field addresses critical issues like organ shortages and post-transplant complications. However, the successful application of these technologies requires careful consideration of their ethical, privacy, and training aspects in healthcare settings.
Reliability and Agreement of Free Web-Based 3D Software for Computing Facial Area and Volume Measurements
Authors: Topsakal Oguzhan , Sawyer Philip , Akinci Tahir Cetin , Topsakal Elif , Celikoyar M. Mazhar
Published: March 2024

Background: Facial surgeries require meticulous planning and outcome assessments, where facial analysis plays a critical role. This study introduces a new approach by utilizing three-dimensional (3D) imaging techniques, which are known for their ability to measure facial areas and volumes accurately. The purpose of this study is to introduce and evaluate a free web-based software application designed to take area and volume measurements on 3D models of patient faces. Methods: This study employed the online facial analysis software to conduct ten measurements on 3D models of subjects, including five measurements of area and five measurements of volume. These measurements were then compared with those obtained from the established 3D modeling software called Blender (version 3.2) using the Bland–Altman plot. To ensure accuracy, the intra-rater and inter-rater reliabilities of the web-based software were evaluated using the Intraclass Correlation Coefficient (ICC) method. Additionally, statistical assumptions such as normality and homoscedasticity were rigorously verified before analysis. Results: This study found that the web-based facial analysis software showed high agreement with the 3D software Blender within 95% confidence limits. Moreover, the online application demonstrated excellent intra-rater and inter-rater reliability in most analyses, as indicated by the ICC test. Conclusion: The findings suggest that the free online 3D software is reliable for facial analysis, particularly in measuring areas and volumes. This indicates its potential utility in enhancing surgical planning and evaluation in facial surgeries. This study underscores the software’s capability to improve surgical outcomes by integrating precise area and volume measurements into facial surgery planning and assessment processes.
Anatomically-Inspired Robotic Finger with SMA Tendon Actuation for Enhanced Biomimetic Functionality
Authors: Liu Renke , Zheng Huakai , Hliboký Maroš , Endo Hiroki , Zhang Shuyao , Baba Yusuke , Sawada Hideyuki
Published: March 2024

This research introduces an advanced robotic finger designed for future generalist robots, closely mimicking the natural structure of the human finger. The incorporation of rarely discussed anatomical structures, including tendon sheath, ligaments, and palmar plates, combined with the usage of anatomically proven 3D models of the finger, give rise to the highly accurate replication of human-like soft mechanical fingers. Benefiting from the accurate anatomy of muscle insertions with the utilization of Shape Memory Alloy (SMA) wires’ muscle-like actuation properties, the bonding in-between the flexor tendons and extensor tendons allows for the realization of the central and lateral band of the finger anatomy. Evaluated using the computer vision method, the proposed robotic finger demonstrates a range of motion (ROM) equivalent to 113%, 87% and 88% of the human dynamic ROM for the DIP, PIP and MCP joints, respectively. The proposed finger possesses a soft nature when relaxed and becomes firm when activated, pioneering a new approach in biomimetic robot design and offering a unique contribution to the future of generalist humanoid robots.
Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction
Authors: Periferakis Argyrios , Periferakis Aristodemos-Theodoros , Troumpata Lamprini , Dragosloveanu Serban , Timofticiuc Iosif-Aliodor , Georgatos-Garcia Spyrangelos , Scheau Andreea-Elena , Periferakis Konstantinos , Caruntu Ana , Badarau Ioana Anca , Scheau Cristian , Caruntu Constantin
Published: March 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others. The materials discussed in the context of this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium phosphate (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), and zirconia. While the recent research results are promising, further development is required to address the increasing antibiotic resistance exhibited by several common pathogens, the potential for fungal infections, and the potential toxicity of some metal nanoparticles. Other solutions, like the incorporation of phytochemicals, should also be explored. Incorporating artificial intelligence (AI) in the development of certain orthopedic implants and the potential use of AI against bacterial infections might represent viable solutions to these problems. Finally, there are some legal considerations associated with the use of biomaterials and the widespread use of 3D printing, which must be taken into account.
Cell Biological and Antibacterial Evaluation of a New Approach to Zirconia Implant Surfaces Modified with MTA
Authors: Fernandes Beatriz Ferreira , Silva Neusa , Da Cruz Mariana Brito , Garret Gonçalo , Carvalho Óscar , Silva Filipe , Mata António , Francisco Helena , Marques Joana Faria
Published: March 2024

Peri-implantitis continues to be one of the major reasons for implant failure. We propose a new approach to the incorporation of MTA into zirconia implant surfaces with Nd:YAG laser and investigate the biological and the microbiological responses of peri-implant cells. Discs of zirconia stabilized with yttria and titanium were produced according to the following four study groups: Nd:YAG laser-textured zirconia coated with MTA (Zr MTA), Nd:YAG laser-textured zirconia (Zr textured), polished zirconia discs, and polished titanium discs (Zr and Ti). Surface roughness was evaluated by contact profilometry. Human osteoblasts (hFOB), gingival fibroblasts (HGF hTERT) and S. oralis were cultured on discs. Cell adhesion and morphology, cell differentiation markers and bacterial growth were evaluated. Zr textured roughness was significantly higher than all other groups. SEM images reveal cellular adhesion at 1 day in all samples in both cell lines. Osteoblasts viability was lower in the Zr MTA group, unlike fibroblasts viability, which was shown to be higher in the Zr MTA group compared with the Zr textured group at 3 and 7 days. Osteocalcin and IL-8 secretion by osteoblasts were higher in Zr MTA. The Zr textured group showed higher IL-8 values released by fibroblasts. No differences in S. oralis CFUs were observed between groups. The present study suggests that zirconia implant surfaces coated with MTA induced fibroblast proliferation and osteoblast differentiation; however, they did not present antibacterial properties.
Supportive Care Needs of Newly Diagnosed Cancer Patients in a Comprehensive Cancer Center: Identifying Care Profiles and Future Perspectives
Authors: Papageorgiou Loula , Le Provost Jean-Bernard , Di Palma Mario , Langlois Marc , Salma Israa , Lopes Manuella , Minvielle Etienne , Abbas Maya , Scotté Florian
Published: March 2024

The prompt introduction of supportive care for patients with cancer leads to a better quality of life, potential survival benefits, and improvements in treatment safety. Considering that patients’ needs vary, descriptive assessments could serve as a compass for an efficient and prompt healthcare response. The aim of this study was to identify supportive care needs in newly diagnosed patients according to cancer type. A retrospective study was conducted by collecting data from the case consultation and medical records of a comprehensive cancer center in France. Patients’ needs were divided into twelve domains: nutrition, psychological support, psychiatric support, social care, physiotherapy, addictology, pain management, palliative care, pharmacology, complementary and alternative practice (CAM), sexual health, and speech therapy. Out of 6217 newly diagnosed patients of various cancer types who sought medical care at Gustave Roussy in 2021, 2541 (41%) required supportive cancer care (SCC), and of them, 1331 patients (52%) required two or more different SCC specialist interventions. The top five interventions were dietary (for 60% of patients), physiotherapy (33%), psychology (29%), social care (28%), and pain management (16%). Subgroup analysis according to cancer department highlighted additional specific needs: CAM for breast cancer patients (11%), speech specialist (27%) and addictologist (22%) interventions for ENT patients, psychiatry consultations for neurological patients (16%), and palliative care for dermatology patients (23%). The aforementioned data suggest that an early, multidisciplinary supportive care intervention should be required. Assembling human resources at the time of diagnosis within a dedicated day unit would be the next appropriate step in developing personalized care pathways related to the highlighted needs.
Franklinite-Zincochromite-Gahnite Solid Solutions for Cool Red Ceramic Pigments with Visible Light Photocatalysis
Authors: Monrós Guillermo , Badenes José A. , Llusar Mario , Delgado Carolina
Published: March 2024

Franklinite-zincochromite-gahnite solid solutions were prepared using ceramic or coprecipitation methods, and their pigmenting capacity as cool ceramic pigments in different glazes (double and single firing frits and porcelain frit) was studied. XRD, UV–Vis–NIR diffuse reflectance, CIEL*a*b* colour analysis, band gap measurements, and the photocatalytic degradation of Orange II were carried out to characterise the samples. The following criteria for high red colouring capacity and high NIR reflectance at the minimum Cr amount were found to be the optimal compositions for an intense reddish cool pigment: Zn(Fe1.8Cr0.2), Zn(Al1.5Cr0.5) and Zn(Al1.3Cr0.5Fe0.2)O4. All the powders showed a direct semiconductor behaviour, with a band gap of approximately 2 eV, which fell in the visible range (620 nm); the visible light photocatalysis of Orange II was moderate, but franklinite-zincochromite Zn(Fe1.8Cr0.2) stood out compared with silver orthophosphate.
Use of Lignite Processing Products as Additives to Road Petroleum Bitumen
Authors: Pyshyev Serhiy , Miroshnichenko Denis , Chipko Taras , Donchenko Myroslava , Bogoyavlenska Olena , Lysenko Liudmyla , Miroshnychenko Mykhailo , Prysiazhnyi Yuriy
Published: March 2024

It is known that there are significant deposits of lignite (brown coal) in Ukraine, particularly in categories A + B + C1. At the same time, certain technical and legal obstacles limit its use as an energy carrier. Therefore, new methods of using lignite and processing its products are necessary. The latter includes humic acids. It was suggested that these acids could be used to stop road bitumens from breaking down. This is because they are antioxidants that contain functional phenolic and carboxyl groups. In particular, this article analyses the nature of the influence of humic acids on the physical and mechanical properties of road petroleum bitumen and its resistance to technological aging. It was found that at a modification temperature of 120 °C (duration-60 min., consumption of humic acids-2.0 wt.%), this additive has a slight negative effect (changes are within permissible limits) on the plastic properties of bitumen and slightly improves its elasticity. The main reason for adding humic acids to road bitumen under the specified conditions is to improve its resistance to technological aging compared to the original binder.
Facile Synthesis Method of Zeolite NaY and Zeolite NaY-Supported Ni Catalyst with High Catalytic Activity for the Conversion of CO2 to CH4
Authors: Krachuamram Somkiat , Kidkhunthod Pinit , Poo-arporn Yingyot , Chanapattharapol Kingkaew Chayakul
Published: March 2024

In this work, the facile reflux method was used as a crystallization procedure for zeolite NaY synthesis. The zeolite mixture was aged for 7 days and then refluxed for crystallization at 100 °C for 12 h. The synthesized zeolite NaY was impregnated with 10, 20 and 30 wt%Ni solution to use as a catalyst for CO2 methanation. The 30 wt% of Ni on the zeolite NaY catalyst showed the highest CO2 methanation catalytic activity, with almost 100% CH4 selectivity. This can be explained by an appropriate H2 and CO2 adsorption amount on a catalyst surface being able to facilitate the surface reaction between them and further react to form products. The oxidation state of Ni and the stability of the catalyst were monitored by time-resolved X-ray absorption spectroscopy. The oxidation state of Ni2+ was reduced during the catalyst reduction prior to the CO2 methanation and it was completely reduced to Ni° at 600 °C. During CO2 methanation, Ni° remained unchanged. In addition, the stability test of the catalyst was conducted by exposing the catalyst to a fluctuating condition (CO2 + H2 and only CO2). The oxidation state of Ni° remained unchanged under the fluctuating condition. This indicated that the Ni/zeolite catalyst has high stability, which can be attributed to an appropriate binding strength between Ni and the zeolite support.
Non-Suicidal Self-Injury (NSSI) Patterns in Adolescents from a Romanian Child Psychiatry Inpatient Clinic
Authors: Andrei Lucia Emanuela , Efrim-Budisteanu Magdalena , Mihailescu Ilinca , Buică Alexandra Mariana , Moise Mihaela , Rad Florina
Published: March 2024

Non-Suicidal Self-Injury (NSSI) involves deliberately causing harm to one’s body without the intention of suicide. As the numbers of adolescents presenting NSSI have been steadily increasing during the last years, we intended to investigate adolescent patients exhibiting NSSI, admitted to our clinic—a Romanian child psychiatry inpatient clinic, over the course of five years. A total of 100 adolescents (80 females, 20 males, mean age: 14.9 years) hospitalized for various neuropsychiatric disorders and engaging in self-harm were studied. The self-harm methods most frequently used in our sample were, for the female group: cutting (all), skin tearing (76%), scratching/pinching (72%), and for males: cutting (all), wound-healing hindrance (85%), striking objects (80%). The initial motivations for NSSI were represented by distress (females 89%, males 90%) and seeking pleasure (females 84%). In terms of the roles of NSSI, it was primarily used for emotional regulation (females 89%) and anger management (males 90%). This study highlights the prevalence of self-harm in hospitalized adolescents, differences in methods and motivations between genders, and the need for more targeted therapy interventions. By documenting trends, investigating underlying motivations and functions, and proposing hypotheses for further research, our findings offer valuable insights on adolescent NSSI and have the potential to increase awareness among various clinicians and specialists who interact with adolescents, thus addressing the escalating prevalence of self-harm behaviours among teenagers.
Ultraviolet Radiation Biological and Medical Implications
Authors: Al-Sadek Tarek , Yusuf Nabiha
Published: March 2024

Ultraviolet (UV) radiation plays a crucial role in the development of melanoma and non-melanoma skin cancers. The types of UV radiation are differentiated by wavelength: UVA (315 to 400 nm), UVB (280 to 320 nm), and UVC (100 to 280 nm). UV radiation can cause direct DNA damage in the forms of cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). In addition, UV radiation can also cause DNA damage indirectly through photosensitization reactions caused by reactive oxygen species (ROS), which manifest as 8-hydroxy-2′-deoxyguanine (8-OHdG). Both direct and indirect DNA damage can lead to mutations in genes that promote the development of skin cancers. The development of melanoma is largely influenced by the signaling of the melanocortin one receptor (MC1R), which plays an essential role in the synthesis of melanin in the skin. UV-induced mutations in the BRAF and NRAS genes are also significant risk factors in melanoma development. UV radiation plays a significant role in basal cell carcinoma (BCC) development by causing mutations in the Hedgehog (Hh) pathway, which dysregulates cell proliferation and survival. UV radiation can also induce the development of squamous cell carcinoma via mutations in the TP53 gene and upregulation of MMPs in the stroma layer of the skin.
Effects of Letrozole Treatment and Vitamin C Supplementation on Morphology, Endoplasmic Reticulum Stress, Programmed Cell Death, and Oxidative Stress in the Small Intestine of Adult Male Rats
Authors: Pilutin Anna , Rzeszotek Sylwia , Wilk Aleksandra , Klimaszewska Klaudia , Łukasiewicz Julia , Mafuta Rufaro Lynnette , Nagendran Thanushan , Ndambara Rupia , Wiszniewska Barbara
Published: March 2024

Estrogens are hormones that play an important role in the digestive tract, including in men. Letrozole is an inhibitor of cytochrome P450 aromatase, an enzyme converting androgens to estrogens. The use of letrozole may cause oxidative stress and endoplasmic reticulum stress in the cells. Factors modulating cellular stress may include vitamin C. The purpose of this study was to examine whether letrozole and/or vitamin C supplementation can affect the morphology of the small intestine, the parameters of endoplasmic reticulum stress, programmed cell death markers, and oxidative damage. Three-month-old male rats were divided into four groups and treated with the following: (I) CTRL—water; (II) CTRL+C—L-ascorbic acid; (III) LET—letrozole; and (IV) LET+C—letrozole + L-ascorbic acid. The morphometrical measurements included epithelial thickness, crypt and lumen area, crypt perimeter, nuclei number in the crypt, and the cell size of crypts. The expression levels of PERK, caspase-3, and catalase were determined. Significant differences in the morphometrical measurements and immunoexpression were observed. This may indicate that chronic treatment with letrozole can affect morphology and induce ER stress, oxidative stress, and programmed cell death in the epithelial cells of the small intestine of adult male rats. Vitamin C supplementation exerts an effect on some parameters of the molecular processes.
Catalyzing Conservation: An Analysis of Fish Stock Dynamics in a Marine Protected Area before and after Artificial Reef Deployment
Authors: Kallianiotis Athanasios , Anastasiadou Chryssa , Batjakas Ioannis
Published: March 2024

The marine ecosystem’s balance is crucial for sustaining biodiversity and supporting fisheries. Marine protected areas have been increasingly used to enhance marine habitats, yet their impact on fish populations remains a topic of debate. This study focuses on a marine protected area in Kitros, Pieria, in Greece, where an artificial reef was constructed, to understand its influence on coastal fish populations. The objectives were to investigate the changes in fish biomass and abundance, comparing the data from periods before and after the construction of an artificial reef. This research compares the data between 2007 and 2008 with the data between 2016 and 2017, collected with bottom trawl surveys strategically executed prior to and after the artificial reef’s installation. Fish species captured were identified, with their lengths and masses measured. The findings indicate an increase in the biomass and abundance of certain fish species after artificial reef deployment, notably the commercially significant Mullus barbatus and Pagellus erythrinus. The artificial reef in Kitros, Pieria, with its surrounding marine protected area appears to have had a positive impact on the local fish populations over the years, suggesting that it can contribute to marine conservation and fishery enhancement. These results underscore the potential of artificial reefs as tools for marine ecosystem management, offering insights for policymakers and environmentalists into coastal resource management.
Correction: Veronico et al. Enhancing Oil-Uptake Efficiency with an Alkyl Polyglycoside–Dodecanol Formulation. Colloids Interfaces 2024, 8, 6
Authors: Veronico Lorenzo , Colafemmina Giuseppe , Gentile Luigi
Published: March 2024

In the original publication [...]
Ionic Strength Effect in the Equilibrium and Rheological Behavior of an Amphiphilic Triblock Copolymer at the Air/Solution Interface
Authors: Carbone Carlo , Guzmán Eduardo , Maldonado-Valderrama Julia , Rubio Ramón G. , Ortega Francisco
Published: March 2024

This study investigates the effect of an inert salt (NaCl) on the equilibrium interfacial tension and dilatational modulus of Pluronic F-68 copolymer, a triblock copolymer consisting of two terminal blocks of poly(ethylene oxide) and a less hydrophilic central block of poly(propylene oxide). Interfacial tension measurements were carried out using a surface force balance and a drop shape tensiometer, while rheological measurements were carried out in two different frequency ranges. This involved the use of the oscillatory barrier/droplet method and electrocapillary wave measurements, complemented by an appropriate theoretical framework. This work aimed to elucidate the influence of NaCl on the interfacial behavior of Gibbs monolayers of Pluronic F-68. In addition, this study highlights some of the technical and theoretical limitations associated with obtaining reliable dilatational rheological data at high frequencies (<1 kHz) using electrocapillary wave measurements. The results provide valuable insights into the interplay between salt presence and interfacial properties of Pluronic F-68 and highlight the challenges of obtaining accurate dilatational rheological data under specific measurement conditions.
Crude Oil Price Movements and Institutional Traders
Authors: Brunetti Celso , Harris Jeffrey H. , Büyükşahin Bahattin
Published: March 2024

We analyze the role of hedge fund, swap dealer, and arbitrageur activity in the crude oil market. The contribution of our work is to examine the role of institutional traders in switching between high-volatility and low-volatility regimes. Using confidential position data on institutional investors, we first analyze the linkages between trader positions and fundamentals. We find that these institutional position changes reflect fundamental economic factors. Subsequently, we adopt a Markov regime-switching model with time-varying probabilities and find that institutional position changes contribute incrementally to the probability of regime changes.