bluuebunny/crossref_metadata_2025 huggingface dataset:
The bidirectional relationship between fatty liver disease and COVID-19
Authors: Liguori Antonio , Calvez Valentin , D’Ambrosio Francesca , Sciarra Angela , Marrone Giuseppe , Biolato Marco , Grieco Antonio , Gasbarrini Antonio , Alisi Anna , Miele Luca
Published: July 2023

COVID-19 and nonalcoholic fatty liver disease (NAFLD) have emerged as global pandemics affecting millions of people worldwide over the past three years. NAFLD is particularly prevalent in individuals with metabolic comorbidities, such as diabetes and obesity, which have been strongly linked to a severe course of Sars-CoV-2 infection. Recently, due to the close association between metabolic abnormalities and NAFLD, the disease has been redefined as metabolic dysfunction-associated fatty liver disease (MAFLD). This review offers an overview of the biological and cellular mechanisms by which COVID-19 can cause liver damage, with a specific focus on the influence of fatty liver in these mechanisms. Additionally, it explores how fatty liver can exacerbate a COVID-19 infection and, conversely, if the presence of COVID-19 may accelerate the development and progression of fatty liver. Finally, the review examines the existing evidence suggesting that NAFLD or MAFLD independently contributes to a heightened severity of COVID-19, while also considering other factors such as age and metabolic comorbidities that may play a role in the disease’s progression.
Electronic skins with multimodal sensing and perception
Authors: Tu Jiaqi , Wang Ming , Li Wenlong , Su Jiangtao , Li Yanzhen , Lv Zhisheng , Li Haicheng , Feng Xue , Chen Xiaodong
Published: July 2023

Multiple types of sensory information are detected and integrated to improve perceptual accuracy and sensitivity in biological cognition. However, current studies on electronic skin (e-skin) systems have mainly focused on the optimization of the modality-specific data acquisition and processing. Endowing e-skins with the abilities of multimodal sensing and even perception that can achieve high-level perception behaviors has been insufficiently explored. Moreover, the perception progress of multisensory e-skin systems is faced with challenges at both device and software levels. Here, we provide a perspective on the multisensory fusion of e-skins. The recent progress in e-skins realizing multimodal sensing is reviewed, followed by bottom-up and top-down multimodal perception. With the deepening understanding of neuroscience and the rapid advance of novel algorithms and devices, multimodal perception function becomes possible and will promote the development of highly intelligent e-skin systems.
Effects of the ACTH6-9-Pro-Gly-Pro peptide on the morphofunctional state of rat colon under conditions of chronic restraint stress
Authors: Vorvul A. O. , Bobyntsev I. I. , Mishina E. S. , Medvedeva O. A. , Andreeva L. A. , Myasoedov N. F.
Published: July 2023

Aim. To study the morphofunctional state of the colonic wall in rats when using the N–terminal analog of the adrenocorticotropic hormone (ACTH) ACTH6-9-Pro-Gly-Pro (ACTH6-9-PGP) peptide under chronic stress.

Materials and methods. The study was performed on 55 male Wistar rats, which were divided into 5 groups (n = 11): group 1 – control group (administration of saline solution without stress); group 2 – chronic restraint stress (CRS) + administration of saline solution; group 3 – CRS + administration of ACTH6-9-PGP at a dose of 5 μg / kg; group 4 – administration of ACTH6-9-PGP at a dose of 50 μg / kg; group 5 – administration of ACTH6-9- PGP at a dose of 500 μg / kg. A histologic examination of the rat colon was performed. The histologic architecture of the colonic wall, the depth of crypts, and the number of goblet cells were assessed. Furthermore, the number of granulocytes, plasma cells, lymphocytes, macrophages, and mast cells was counted.

Results. The study demonstrated that chronic (14 days) restraint stress resulted in the development of inflammations in the colonic wall of the animals. Intraperitoneal administration of ACTH6-9-PGP at doses of 50 and 500 μg / kg daily throughout the entire time of stress exposure prevented the development of stress-induced alterations observed in the control animals. At the same time, anti-inflammatory effects of the peptide in the colonic wall and a decrease in the level of corticosterone in the blood serum were noted.

Conclusion. The results of this work and data from other studies on the effects of N-terminal analogs of ACTH indicate the need for studying the mechanisms of their effect on inflammation and searching for targets of ACTH6-9-PGP.
Modern concepts in cervical carcinogenesis
Authors: Naumova L. A. , Starodumova V. A.
Published: July 2023

The article discusses modern ideas about cervical carcinogenesis as a multi-stage process of multifactorial genesis. Currently, ideas about the pathogenesis of cervical cancer (CC) are based not only on understanding the role of high-risk oncogenic human papillomavirus (HPV) in this process and accumulation of genetic changes caused by it, but also on formation of a complex HPV interactome, or a network of intermolecular interactions of HPV oncoproteins with host cell proteins. Carcinogenesis also involves a wide range of epigenetic events and, above all, impairment of the regulatory function of miRNAs. An important role in cervical carcinogenesis is attributed to the concept of cancer stem cells (CSCs) formulated in recent years, which is closely related to the explanation of disease recurrence and treatment resistance, as well as to new approaches to treatment. The cervicovaginal microbiome and cervical microenvironment, which are responsible for natural clearance of HPV, regression of epithelial lesions, and modeling of the immune response, are becoming promising objects for research.

The aim of the review was to present up-to-date information on the most important mechanisms of cervical carcinogenesis, as well as on new approaches to the treatment of CC, based, in particular, on the use of knowledge about regulatory miRNAs, CSC markers, and the state of the cervicovaginal microbiota.
Study of molecular genetic markers of Gilbert’s syndrome
Authors: Ivanova A. A. , Gurazheva A. A. , Mel’nikova E. S. , Maksimov V. N. , Nemcova E. G.
Published: July 2023

Aim. To study new molecular genetic markers of Gilbert’s syndrome (GS).

Materials and methods. It was a case – control study. The GS group included 125 people (mean age 38.5 ± 11.9 years, 58.9% were men) with unconjugated hyperbilirubinemia; known causes of unconjugated hyperbilirubinemia were excluded. The control group (n = 323, mean age 48.9 ± 11.9 years, 53.2% were men) was a random sample of individuals from the DNA bank of participants of the HAPIEE and MONICA projects. DNA was isolated by phenol – chloroform extraction from venous blood. Genotyping of groups by rs3064744, rs34993780, rs56059937, rs4148323, and rs4124874 single nucleotide polymorphisms (SNPs) in the UGT1A1 gene was performed by polymerase chain reaction followed by the polyacrylamide gel analysis according to the author’s protocols.

Results. For rs34993780 and rs56059937, no carriers of a rare allele were found in the GS group and the control group. In the GS group, two carriers of a heterozygous mutation rs4148323 were found. Statistically significant differences between the groups were found in the frequencies of rs4124874: homozygous GG was statistically significantly more common in the GS group than in the control group (odds ratio (OR) = 11.8, 95% confidence interval (CI) 6.9–20.3, p < 0.001).

Conclusion. The GG genotype of rs4124874 in the UGT1A1 gene is associated with an increased risk of GS. Carriers of the rare heterozygous mutation rs4148323 were found in the GS group.
Galectin-3 in the blood serum of patients with bone tumors
Authors: Kushlinskii N. E. , Kovaleva O. V. , Prishchep P. L. , Zybina N. N. , Jurisic V. , Alferov A. A. , Kuzmin Yu. B. , Goryacheva I. O. , Kuznetsov I. N. , Bulytcheva I. V. , Varfolomeeva S. R. , Sushentsov E. A. , Gershtein E. S. , Rogozhin D. V. , Yanushevich O. O. , Stilidi I. S.
Published: July 2023

Background. Due to diversity of cancer, the functional role of galectin-3 is rather controversial; however, for many types of neoplasms, the marker acts as a tumor growth promoter.

Aim. To perform a comparative analysis of galectin-3 levels in the blood serum of healthy individuals and patients with benign, borderline, and malignant bone tumors divided into two age groups (under and over 18 years of age) based on the main clinical and morphological characteristics of the disease and prognosis.

Materials and methods. The study included 201 patients with benign, borderline (giant cell tumors, locally aggressive tumors), and malignant bone tumors and 31 healthy donors. The galectin-3 level was determined in the blood serum before treatment with Human Galectin-3 ELISA kit (R&D, USA).

Results. The level of galectin-3 in the blood serum of patients with benign and malignant bone tumors was statistically significantly higher than that in the control group of patients both under and over 18 years. In patients with borderline bone tumors, a trend toward an increase in the galectin-3 concentration compared with the controls was revealed. The ROC analysis for galectin-3 in patients with bone sarcomas showed that the area under the curve (AUC) comprised 0.795 (р < 0.0001) in the group of patients over 18 years and 0.868 (р = 0.0008) in the individuals under 18 years. For malignant bone tumors in patients over 18 years, the sensitivity of this method was 71.3%, and specificity was 71.43% (optimal cut-off level was 8.09 ng / ml; р < 0.0001), while in patients under 18 years, the sensitivity of the method was 80%, and specificity was 90% (optimal cut-off level was 5.49 ng / ml; р < 0.001). No significant associations between the serum galectin-3 level and the clinical and morphological characteristics of bone neoplasms were found both in patients under and over 18 years of age. However, it could be noted that the highest concentration of the marker was found in chordomas and at earlier stages of the disease. In patients over 18 years with chondrosarcoma and osteosarcoma, no correlation between the marker and the disease prognosis was found.

Conclusion. An increase in the galectin-3 level in the blood serum was observed in all age groups of patients with both benign and malignant bone tumors. However, the sensitivity and specificity of the method assessed by the ROC analysis do not allow to apply this marker for the diagnosis of bone tumors.
Processamento e caracterização de chips de inhame saborizados
Authors: Soares Azevedo Vitória Virgínia , Alves de Souza Leandro , Kelly Lima Hunaldo Virlane , Hunaldo dos Santos Leonardo , Nunes Climaco Gabrielli , Silva de Sousa Marcos , Nunes dos Santos Leticia
Published: July 2023

O inhame é um tubérculo nativo de regiões tropicais, rico em nutrientes como proteínas, fibras, fósforo, potássio e vitaminas do complexo B, objetivou neste trabalho produzir chips de inhame e realizar a caracterização microbiológica, físico-química e sensorial dos produtos, os mesmos sendo submetidos a secagem artificial e a fritura em óleo de girassol. Os chips de inhame foram submetidos ao pré-tratamento osmótico com concentração de 18% de sal, 6% de cebola desidratada, 6% de açafrão, 6% de alho em pó e 6% de orégano por 5h a 55°C. Os chips foram avaliados quanto às características físico-químicas de atividade de água, 0,56 (formulação 1); 0,40(formulação 2); pH, 6,38 e 5,90, formulação 1 e 2, respectivamente e coloração considerando as coordenadas L*, a* e b*. Na avaliação sensorial foi utilizada a estrutura de escala hedônica de 9 pontos e o teste de intenção de compra. A formulação 2 foi mais aceita entre todos os atributos sensoriais, cor, aroma, sabor, textura, aparência e impressão global.
Desenvolvimento de biocompósito utilizando resíduos agroindustriais e macrofungo
Authors: De Oliveira Álefe Galbiatti , Kuss Mariane de Almeida , Silva Melissa Justino da , Rodrigues Kethylyn Tomazelli , Ribeiro Reginaldo Vicente
Published: July 2023

A sociedade está passando por uma nova etapa de desenvolvimento tecnológico e científico que urge inovações para aplicação de uma Bioeconomia sustentável a fim de reduzir impactos ambientais como o acúmulo de materiais poliméricos sintéticos derivados do petróleo que, consequentemente, promove a contaminação do solo, devido a sua difícil degradação. Junto a isso, resíduos orgânicos agroindustriais necessitam de aproveitamento, a fim de aumentar seu valor agregado, o que contribui para uma Bioeconomia Circular. Assim, o objetivo deste trabalho é aproveitar a capacidade do micélio fúngico em incorporar resíduos orgânicos, acelerar a decomposição e produzir um composto biodegradável para desenvolver um biocompósito, utilizando resíduos agroindustriais como substrato. A metodologia utilizada iniciou a partir de uma pesquisa bibliográfica para evidenciar um macrofungo com potencial de crescimento rápido, e finalizou com um trabalho prático de cultivo fúngico para o desenvolvimento micelial. Como resultado, identificou-se a condição de produção mais promissora de biocompósito obtido entre as diferentes formulações de substrato considerando suas características físicas, a fim de obter um biocompósito para produção de futuros produtos biodegradáveis.
Cell Life Cycles Top Trumps: Deluxe
Authors:   University of Dundee, Williams Thomas
Published: July 2023

All living things from whole people to single cells and even viruses have life cycles. Explore the weird and wonderful world of life cycles at the level of the cell in this top trumps inspired game. Print and cut out the cards, then play anywhere you want! The deluxe edition contains fantastic new artwork from artist Emily Gullberg. Great for 2-3 people age 6+, lasts around 10 mins per game.
The Effect of Dietary Components of the Mediterranean Diet on Food Allergies: A Systematic Review
Authors: Panagiotou Eleftheria , Andreou Eleni , Nicolaou Stella A.
Published: July 2023

Allergies are a common and increasing health problem affecting millions of people worldwide. In addition to genetic predisposition, this increase in allergic cases is attributed to air pollution, climate change, more time spent indoors, lack of physical activity, and alterations in eating habits. The Mediterranean diet (MD), which includes a lot of fruits and vegetables, whole grains, legumes, nuts, olive oil and fish has been linked to a variety of health benefits, including a lower risk of chronic and allergic diseases. The purpose of this paper is to explore the effects of the dietary components of the MD on food allergies. Electronic databases PubMed, Scopus, Science Direct, and EBSCO were used to conduct this systematic review up to March 2023. 696 studies were initially identified and nine were included (five human and four animal studies). The findings of this review showed an overall beneficial effect between the food components of the MD and food allergies. Although the results are promising, the limited number of studies highlights the need for more research.
Prediction and Prevention of Preterm Birth: Secondary Analysis of a Randomized Intervention Trial
Authors: Combs C. Andrew , Zupancic John A.F. , Walker Michael , Shi Jing
Published: July 2023

Our objective was to evaluate whether pregnancy is prolonged by use of a proteomics-based maternal serum screening test followed by treatment interventions. This is a secondary analysis of the PREVENT-PTB randomized trial comparing screening with the PreTRM test versus no screening. The primary trial analysis found no significant between-group difference in preterm birth rate. Rather than considering a dichotomous outcome (preterm vs term), we treated gestational age at birth as a continuous variable using survival analysis. We also evaluated between-group difference in NICU length of stay and duration of respiratory support. Results indicated that pregnancy was significantly prolonged in subjects screened with PreTRM test compared to controls (adjusted hazard ratio 0.53, 95% confidence interval 0.36-0.78, P <0.01). Newborns of screened subjects had significantly shorter NICU stay but no significant decrease in duration of respiratory support. In the PreTRM screen-positive group, interventions that were associated with pregnancy prolongation included care management and low-dose aspirin but not 17-hydroxyprogesterone caproate. We concluded that screening with the PreTRM test followed by interventions for screen-positive pregnancies can prolong pregnancy and reduce NICU-LOS.
PBS QDs Coated Si Micro-Holes Array/Graphene vdW Schottky Near-Infrared Photodiode for PPG Heart-Rate Measurement
Authors: Xu Mingyuan , Cui Yinghao , Zhang Tao , Lu Mengxue , Yu Yongqiang
Published: July 2023

Near-infrared (NIR) photodetectors (PDs) have attracted much attention in noninvasive medical diagnosis and treatment. Especially, the self-filtered NIR PDs are highly demandable for tremendous biomedical application due to their strong ability in wavelength discrimination. In this work, we designed and then fabricated a Si micro-holes array/Graphene (Si MHA/Gr) van der Waals (vdW) Schottky NIR photodiode by using PbS quantum dots (QDs) coating. The device exhibits a unique self-filtered NIR response with a responsivity of 0.7 A/W at -1 V and a response time of 61 μs, which are higher than that without PbS QDs coating and even most of previous Si/Gr Schottky photodiodes. The light trapping of the Si MHA and the PbS QDs coating can be attributed to the high responsivity of the vdW photodiode. Furthermore, the presented NIR photodiode can also be integrated in photoplethysmography (PPG) for real-time heart-rate (HR) monitoring. The extracted HR is in great accord with the value measured with the patient monitor by analyzing the Fourier transform of the stable and reliable fingertip PPG waveform, suggesting its potential for practical applications.
Bi-SQUID versus dc SQUID in Flux Driven Traveling-Wave Parametric Amplifier
Authors: Nikolaeva Alena N , Kornev Victor K , Kolotinskiy Nikolay V.
Published: July 2023

Characteristics of artificial waveguide lines composed of finite size artificial cells are analyzed and discussed with relation to designing the travelling wave parametric amplifiers. From this point of view, flux driven amplifier suggested recently can be considered as the most successful amplifier design. To increase dynamic range of the amplifier, dc SQUID cells of the artificial line in use can be substituted for bi-SQUID cells. The 1-dB compression points of the amplifier gain are calculated and compared for both types of the cells.
Response of G-NUMEN LaBr3(Ce) Detectors to High Counting Rates
Authors: Gandolfo Elisa Maria , Oliveira José Roberto Brandao , Campajola Luigi , Pierroutsakou Dimitra , Boiano Alfonso , Agodi Clementina , Cappuzzello Francesco , Carbone Diana , Cavallaro Manuela , Ciraldo Irene , Calvo Daniela , Delaunay Franck , Eke Canel , Longhitano Fabio , Medina Nilberto , Moralles Mauricio , Sartirana Diego , Sharma Vijay , Spatafora Alessandro , Toufen Dennis , Finocchiaro Paolo
Published: July 2023

The G-NUMEN array is the future gamma spectrometer of the NUMEN experiment (Nuclear Matrix Element for the Neutrinoless double beta decay), to be installed around the object point of the MAGNEX magnetic spectrometer at the INFN-LNS laboratory.. This project aims at exploring Double Charge Exchange (DCE) reactions in order to obtain crucial information about the neutrinoless double beta decay (0νββ). The primary objective of the G-NUMEN array is to detect the gamma rays emitted from the de-excitation of the excited states populated via DCE reactions with good energy resolution and detection efficiency, amidst a background composed of transitions from competingreaction channels with far higher cross-sections. To achieve this, the G-NUMEN signalswill be processed in coincidence with those generated by the detection of the reaction ejectiles in the MAGNEX Focal Plane Detector(FPD). Under the expected experimental conditions, G-NUMEN detectors will operate at high counting rates, of the order of hundreds of kHz per detector, while maintaining excellent energy and timing resolutions. The complete array will consist of over 100 LaBr3(Ce) scintillators. Initial tests have been conducted on the first detectors of the array, allowing for the determination of their performance at high rates.
Feature Selection with Weighted Ensemble Ranking for Improved Classification Performance on the CSE-CIC-IDS2018 Dataset
Authors: Göcs László , Johanyák Zsolt Csaba
Published: July 2023

Feature selection is a crucial step in machine learning, aiming to identify the most relevant features in high-dimensional data, in order to reduce the computational complexity of model development and improve its generalization performance. Ensemble feature ranking methods combine the results of several feature selection techniques to identify a subset of the most relevant features for a given task. In many cases, they produce a more comprehensive ranking of features than the individual methods used in them. This paper presents a novel approach to ensemble feature ranking, which uses a weighted average of the individual ranking scores calculated by the individual methods. The optimal weights are determined using a Taguchi-type design of experiments. The proposed methodology significantly improves classification performance on the CSE-CIC-IDS2018 dataset, particularly for attack types where traditional average-based feature ranking score combinations resulted in low classification metrics.
Airway Space Changes in Dentofacial Deformity After Two-Jaw Orthognathic Surgery in Class II and Class III Skeletal Conditions
Authors: Ravelo Victor , Olate Gabriela , Unibazo Alejandro , De Moraes Marcio , Olate Sergio
Published: July 2023

Orthognathic surgery is used to modify anomalies in maxillomandibular position; this process can significantly affect the anatomy of the airway and cause functional changes. This study aims to define the impact of mandibular maxillary movement on the airway of subjects with dentofacial deformity. A retrospective study was conducted on subjects with Angle class II (CII group) and Angle class III (CIII group) dentofacial deformities. The subjects were treated by bimaxillary surgery; for all of them, planning was performed with software and 3D printing. Cone beam computed tomography (CBCT) was obtained 21 days before surgery and 6 months after surgery and was used for planning and follow-up with the same conditions and equipment. Was used the superimposition technique to obtain the maximum and minimum airway areas, and total airway volume. The data were analyzed with the Shapiro-Wilk test and Student’s t-test, while Spearman's test was used to correlate the variables, considering a value of p<0.05. Seventy-six subjects aged 18 to 55 years (32.38 ± 10.91) were included: 46 subjects were in CII group, treated with a maxillo-mandibular advancement, and 30 subjects were in the CIII group, treated with a maxillary advancement and a mandibular setback. In CII group, a maxillary advancement of +2.45 mm (±0.88) and a mandibular advancement of +4.25 mm (±1.25) were observed, with a significant increase in all the airway records. In the CIII group, a maxillary advancement of +3.42 mm (±1.25) and a mandibular setback of -3.62 mm (±1.18) was noted, with no significant changes in the variables measured for the airway (p>0.05). It may be concluded that maxillo mandibular advancement is an effective procedure to augment the airway area and volume in the CII group. On the other hand, in subjects with mandibular prognathism and Angle class III operated with the maxillary advancement and mandibular setback lower than 4 mm it is possible to not reduce the areas and volume in the airway.
Phase Stabilization of a Terahertz Wave using Mach-Zehnder Interference Detection
Authors: Ibrahim Amalina Athira , Li Bo , Ye Shenghong , Shiramizu Takashi , Chen Hanwei , Mikami Yuya , Kato Kazutoshi
Published: July 2023

As a high-frequency carrier, the Terahertz (THz) wave is essential for achieving high-data-rate wireless transmission due to its ultra-wide bandwidth. Phase stabilization becomes crucial to enable phase-shift-based multilevel modulation for high-speed data transmission. We developed a Mach-Zehnder interferometric phase stabilization technique for photomixing, which has proved a promising method for phase-stable continuous THz-wave generation. However, this method faces inefficiencies in generating phase-modulated THz waves due to the impact of the phase modulator on the phase stabilization system. By photomixing, which is one of the promising methods for generating THz waves, the phase of the generated THz waves can be controlled in the optical domain so that the stability of the generated THz wave can be controlled by photonics technologies. Thus, we have devised a new phase stabilization approach using backward-directional lightwave, which is overlapped with the THz wave generation system. This study presents a conceptual and experimental framework for stabilizing the phase differences of optical carrier signals. We compare the optical domain and transmission performances between forward-directional and backward-directional phase stabilization methods. Remarkably, our results demonstrate error-free transmission at a modulation frequency of 3 Gbit/s and higher.
Does Accelerometry at the Centre of Mass Accurately Predict the Gait Energy Expenditure in Patients with Hemiparesis?
Authors: Barassin Leo , Pradon Didier , Roche Nicolas , Slawinski Jean
Published: July 2023

Background: The aim of this study was to compare energy expenditure (EE) predicted by accelerometery (EEAcc) with indirect calorimetry (EEMETA) in individuals with hemiparesis. Methods: Twenty-four participants (12 with stroke and 12 healthy controls) performed a six-minute walk test (6MWT) during which EEMETA was measured using a portable indirect calorimetry system and EEACC was calculated using Bouten’s equation (1993) with data from a 3-axis accelerometer positioned between L3 and L4. Results: Median EEMETA was 9.85 [8.18;11.89] W·kg-1 in the stroke group, and 5.0 [4.56;5.46] W·kg-1 in the control group. Median EEACC was 8.57 [7.86;11.24] W·kg-1 in the control group and 8.2 [7.05;9.56] W·kg-1 in the stroke group. EEACC and EEMETA were not significantly correlated in either the control (p=0.8) or the stroke groups (p=0.06). The Bland-Altman method showed a mean difference of 1.77±3.65 W·kg-1 between EEACC and EEMETA in the stroke group and -2.08±1.59 W·kg-1 in the controls. Conclusions: The accuracy of the predicted EE, based on the accelerometer and the equations proposed by Bouten et al, is low in individuals with hemiparesis and impaired gait. This combination (sensor and Bouten's equation) is not yet suitable for use as a stand-alone measure in clinical practice for the evaluation of hemiparetic patients.
Recent Advances in the Study of Huntingtin Interacting Proteins
Authors: Li SHIHUA , Tong Huichun , Zhou Gongke , Liu Li , Chen Xing-xing , Li Xiao-Jiang , Sun Yize , Yang Tianqi
Published: July 2023

Huntington's disease (HD) is caused by an expansion of a CAG repeat in the gene that encodes the huntingtin protein (HTT). The exact function of HTT is still not fully understood, and previous studies have mainly focused on identifying proteins that interact with HTT to gain insights into its function. Numerous HTT-interacting proteins have been discovered, shedding light on the functions and structure of HTT. Most of these proteins interact with the N-terminal region of HTT. Among the various HTT-interacting proteins, huntingtin-associated protein 1 (HAP1) and HTT-interacting protein 1 (HIP1) have been extensively studied. Recent research has uncovered differences in the distribution of HAP1 in monkey and human brains compared to mice. This finding suggests that there may be species-specific variations in the regulation and function of HTT-interacting proteins. Understanding these differences could provide crucial insights into the development of HD. In this review, we will focus on the recent advancements in the study of HTT-interacting proteins, with particular attention to the differential distributions of HTT and HAP1 in larger animal models.
Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Periodontal Diseases
Authors: Giannini Giuseppe , Ragusa Irene , Nardone Giulia Nerina , Soldi Sara , Elli Marina , Valenti Piera , Rosa Luigi
Published: July 2023

: An innovative and stable probiotics-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated with periodontal diseases. Tau-Marin gel was tested against some pathogenic bacteria, belonging to the so-called "red complex", recognized as the most important pathogens in plaque specimens, adherent to the epithelial lining of periodontal pockets. A detailed physico-chemical profile of AL0020 and its in vitro efficacy in protecting activity against pathogenic bacteria as well as soothing or irritative effect on gingival epithelium were reported. Moreover, a clinical-dermatological trial on 20 volunteers using the product once a day for 30 days was also performed.
Using Grid Search and Guided Random Search (Simulated Annealing) Methods in Determining the Earthquake Hypocenter in the Majalengka Region, West Java on November 11, 2021
Authors: Pramudya Fachri Aldi , Ningsih Restu , Nurfaidah Hayu , Sephiana Siska Erna , Wibowo Rahmat Catur , Zaenudin Ahmad
Published: July 2023

Tectonic earthquakes are generally caused by the release of energy produced by a pressure from a moving slab. This study aimed to test the use of grid search methods and guided random search in determining the hypocenter position of the earthquake in the case of the Majalengka regional earthquake, West Java which occurred on November 11, 2021. In this study used earthquake source data with the number of 5 stations, are COCO, KAPI, PALK, MBWA, and NWAO which can be accessed on the IRIS. From the results of determining the earthquake hypocenter using the grid search method, the position of the earthquake hypocenter is obtained with a latitude position of 6.596861oS and for a longitude position of 108.2871°E with a depth of 200 km, while from the processing of the simulated annealing method, the latitude position is 6.501645°S and longitude 108.2252°E with depth of 172.1 km. Meanwhile, if we compare the position of the earthquake hypocenter according to IRIS, are the latitude position of 6.6027°S and for the longitude position of 108.105°E with a depth of 164.41 km, because the hypocenter data from IRIS has been revised by a seismologist so that it is used as a reference, the results that are closest to the position according to IRIS are the results of the simulated annealing method.
The Significance Relationship between Palynomorph Fossil Preservation and Grain Size in Rock: Case Study of Walat and Batuasih Formations, Sukabumi, West Java
Authors: Rachman Rizki Satria , Winantris Winantris
Published: July 2023

Palynomorph is dust-sized material that is resistant to acids and can be preserved as fossils in sedimentary rocks. Fossil content in rocks is very diverse which is influenced by various factors, one of this factors is the texture of rock in form of grain size. The Walat and Batuasih Formations are sedimentary rock formations that have variety of grain sizes. This research aims to examine relationship or correlation between grain size and palynomorph preservation in rocks with case studies in the Walat and Batuasih Formations. 42 samples were taken from measured stratigraphic section and analyzed both grain size and palynomorph content. Statistical analysis with Normality Test using Shapiro Wilk and Liliefors; Homogeneity Test using Levene Test; and Non-Parametric Associative Test using Spearman Rank was conducted to see the relationship of these variables. Result, the Walat and Batuasih Formations have conglomerate, sandstone, mudstone and coal lithologies with quite variety of palynomorphs. Statistical results show that all variables have data that are not normally distributed with tendency to be non-homogeneous. Moreover, it was found that the grain size of rock had significant effect on the preservation of palynomorphs in the rock. Clay grains has positive correlation of 0.613 and sand grains has negative correlation of -0.653. This shows that the finer the grain size, the more effective the preservation of palynomorphs is.
Susceptibility of the Surrounding Soil and Rock by the Electrical Resistivity Method
Authors: Husain Ratna , Sultan Sultan
Published: July 2023

The research area is located in Banga, Soppeng Regency, South Sulawesi Province. The purpose and intent of this research is to determine the resistivity value of the material layer, identify the characteristics of the slip plane and its relationship to the plasticity properties and the characteristics of the clay minerals contained in the soil. The method used to collect field data includes surface geological data and subsurface geology, which are the electrical resistivity data and surface soil data, then interpreted by combining topographiccross-sectional data and subsurface geoelectrical data along the measurement path. The first slip plane is curved as well as the second slip plane is the residual soil resulting from weathering of limestone which is still above the less dense and thick parent rock (in situ). The geochemistry of the soil samples showed that the mineral content in each layer had the largest percentage of illite 54.4% - 69.9%, and montmorillonite 6.1% - 13.6%, these two clay minerals have large shrinkage properties. Plasticity Index 29.8% - 35.8%, causing vulnerability to the soil, so that the mass movement on the sliding plane is moderate and active in slow motion. The mass movement in the slip plane can be categorized into creep type.
Future Research on Theories of Evil:
An Insuperable Blind Spot?
Authors: Carrim Sabah
Published: July 2023

This reflection explores the theories of evil in the field of genocide studies and highlights a ‘blind spot’ in understanding the motives behind mass killings. It discusses various theories of evil, ranging from individual-based to situational factors, and emphasizes the need for a nuanced understanding of diverse and complex motives. The reflection suggests that incorporating neuroscience into genocide studies may shed light on the motives behind violence by examining the impact of brain trauma and injury. However, it also raises questions about the extent to which neuroscience can provide a comprehensive explanation for motive and the implications of using neuroscientific evidence in genocide trials. The reflection concludes by discussing the limitations of attributing complete responsibility to the brain and the role of behavioral science in understanding criminal responsibility.
Ensayo, autobiografía, series: la belleza de Andarse por las tramas
Authors: Cepedello María Paz
Published: July 2023

Tribuna a tenor de la publicación hace unos meses de una obra de creación literaria que tiene por objeto de reflexión y creación las series televisivas.
Los bailarines más allá de los estereotipos: la necesidad de una representación auténtica en la ficción audiovisual
Authors: Navarro Sanler Ioshinobu
Published: July 2023

La ficción audiovisual puede ser una herramienta poderosa para representar la danza, pero a menudo perpetúa estereotipos negativos y poco realistas sobre los bailarines. Este artículo explora la necesidad de representar la danza de manera auténtica en la ficción audiovisual y cómo esto puede ayudar a desafiar y desmontar los estereotipos existentes. Los estereotipos en la ficción audiovisual a menudo representan a los bailarines como superficiales, obsesionados con su imagen corporal y perfección física. Sin embargo, esta representación no es realista y puede tener consecuencias negativas en la autoestima de los bailarines y en su inclusión en la sociedad. Es importante que la representación de la danza en la ficción audiovisual sea auténtica, puede ayudar a desmontar los estereotipos sobre los bailarines, promover la inclusión y apoyar la diversidad, incluyendo una amplia variedad de experiencias culturales, raciales, de género y socioeconómicas. Además, la representación debe presentar la técnica de la danza de manera accesible al público general y evitar la idealización de la perfección física.
¿Culpable o no?
Authors: Spataro Carolina , Leonor Silba Malvina , Borda Libertad
Published: July 2023

El objetivo del artículo es analizar Luis Miguel: la serie como exponente de un género en auge del panorama audiovisual actual e indagar de qué modo esta bioserie logra articular un fenómeno actual en el campo del entretenimiento -mercado de la nostalgia- con elementos de larga data en la cultura popular y de masas, como el melodrama. A lo largo de tres temporadas, la serie procura dar respuesta a necesidades de la industria, satisfacer expectativas de los públicos, incluir la problemática de la violencia de género y activar la memoria colectiva a través de sus canciones de amor. En el primer apartado abordamos las características de este producto como un ejemplo del género bioserie y su imbricación en el largo derrotero de la matriz melodramática. En el segundo analizamos la centralidad que adquiere la violencia como marco explicativo de la vida del cantante, en un clima de época marcado en los últimos años por la masificación de los feminismos en la región. En el tercer apartado, hacemos eje en los conflictos personales y profesionales que el cantante atraviesa y el giro autorreferencial de la serie, que termina contando la historia de cómo se gestó el producto.
Massimo Fusillo, Mirko Lino, Lucia Faenza, Lorenzo Marchese (eds.) (2021). Oltre l’adattamento? Narrazioni espanse: intermedialità, transmedialità, virtualità. Bologna: il Mulino, 322 pp. ISBN: 978-88-15-28779-3
Authors: Garosi Linda
Published: July 2023

«¿Más de la adaptación?» es la pregunta que se plantean los editores de este volumen y alrededor de la cual se vertebran los quince estudios que reúne. Un volumen vario que pretende ofrecer una visión amplía y abierta mediante la cual encuadrar los fenómenos transmediales atendiendo tanto a rasgos de continuidad como de ruptura entre las formas, códigos y media.
Asociación entre la mastectomía y la disfunción sexual femenina en el "Hospital Nacional Guillermo Almenara Irigoyen"
Authors:   , Salas Alosilla Fabrizio
Published: July 2023

Introducción y objetivo: La neoplasia de mama tiene gran relevancia a nivel mundial, con una alta incidencia y baja mortalidad en la población peruana, siendo el manejo quirúrgico de gran importancia. En la mujer, la mama es considerada un símbolo de feminidad y sexualidad; y al ser extirpada, en muchos casos, tendría como repercusión la limitación de la actividad sexual, así como problemas de autoestima, perjudicando su calidad de vida. El objetivo del presente estudio es demostrar si existe una relación entre la mastectomía y el riesgo de disfunción sexual femenina subsecuente. Material y métodos: Estudio observacional analítico transversal ejecutado en pacientes mastectomizadas por cáncer de mama en el “Hospital Nacional Guillermo Almenara Irigoyen”. Se incluyeron 60 pacientes operadas de mastectomía radical modificada entre 2015–2020. La disfunción sexual se evaluó mediante el cuestionario Índice de Función Sexual Femenina (IFSF). Resultados: Se obtuvo una mediana de 61 años, el 83.3% procedieron de Lima, 75% fueron tratadas con quimioterapia, 46.67% refiere no tener estabilidad de pareja. Se halló significancia estadística entre la edad y la disfunción sexual (p<0.004) y la estabilidad de pareja con la disfunción sexual (p<0.005). No se observó resultados significativos en las otras variables. Se encontró que a mayor edad existe menor puntaje del IFSF, y por ende mayor disfunción sexual (p ≤0.001). Los ítems más afectados fueron: excitación, lubricación, orgasmo y dolor. Conclusiones: Las mujeres peruanas con mastectomía por cáncer de mama, tienden a presentar altos porcentajes de disfunción sexual (86.67%). Existe relación entre la edad y la disfunción sexual, así como de la estabilidad de pareja.
T cells targeting peripheral nerves are expanded and shared in patients with Guillain-Barré Syndrome.
Authors: Súkeníková* Lenka , Mallone* Anna , Schreiner Bettina , Ripellino Paolo , Nilsson Jakob , Sallusto Federica , Latorre Daniela
Published: July 2023

Guillain-Barré syndrome (GBS) is a rare and potentially life-threatening disorder of the peripheral nervous system usually triggered by a preceding infection and causing a rapidly progressive muscle weakness. While the disease is generally considered to have an autoimmune basis, the cellular and molecular players underlying its immunopathology are mostly elusive. By combining in vitro T cell screenings, generation of T cell clones and high throughput TCRVβ sequencing, we reveal the existence of autoreactive memory CD4+ and rare CD8+ T cells targeting myelin antigens of the peripheral nerves in GBS patients. The characterization of more than 1000 autoreactive single T cell clones uncovered a polyclonal TCR repertoire and short CDR3β lengths, a preferential HLA-DR restriction and immunodominant epitopes recognition across patients. Autoreactive clonotypes were expanded in the blood of the same patient at different disease stages and, importantly, were shared in the blood and cerebrospinal fluid of different GBS patients, but not in control individuals. Finally, myelin-reactive CD4+ T cells were identified in the nerve biopsy of one GBS patient, indicating their direct contribution to disease physiopathology. Collectively, our data provide the first description of autoreactive T cells in GBS patients and open new perspectives in the field of peripheral inflammatory neuropathies, with potential significant translational impact for biomedical applications.
Investigation of DC and RF Characteristics of Recessed Gate III-Nitride nano-HEMT on β-Ga2O3 Substrate with Back-Barrier for High-Power and High-Frequency Applications
Authors: Rao G. Purnachandra , Lenka Trupti Ranjan , Boukortt Nour El. I. , Nguyen Hieu Pham Trung
Published: July 2023

In this research study, a recessed gate III-Nitride based nano high electron mobility transistor (HEMT) grown on a lattice matched β-Ga2O3 substrate is designed. This research investigation aims to enhance DC and RF performance of AlGaN/GaN HEMT, and minimize the short-channel effects by incorporating an AlGaN back layer and field plate technique, which can enhances electron confinement in two-dimensional electron gas (2DEG). A precise comparison analysis is done on the proposed HEMT’s input characteristics, output characteristics, leakage current characteristics, breakdown voltage properties, and RF behaviour in presence and absence of AlGaN back layer in regards to field plate configuration. The inclusion of back barrier aids in raising the level of conduction band, which reduces leakage loss beneath the buffer, and aids in keeping the 2DEG to be confined to narrow channel. Furthermore, the field plate design offers an essential electric field drift between gate and drain, resulting to enhanced breakdown voltage characteristics. The proposed recessed gate HEMT with intended Al0.1Ga0.9N layer between GaN buffer and β-Ga2O3 substrate along with field-pated arrangement exhibited a superior performance attributes.
Does the Low Carbon Transition Impact Urban Resilience？ Evidence from China's Pilot Cities for Carbon Emissions Trading
Authors: zhang sisi , Ma Xiaoyu , cui qi , liu jiamin
Published: July 2023

The low-carbon transition is a systemic economic and social change that will inevitably have an impact on many areas of the urban system. Among them, has China's ongoing low-carbon transition had an impact on urban resilience (UR) systems while achieving urban energy saving and carbon emission reduction goals? This paper uses the implementation of the carbon emissions trading pilot policy (CETPP) as a "quasi-natural experiment", and evaluates the impact of the policy on UR using a difference-in-differences model based on the data of prefecture-level cities from 2011 to 2020. The study shows that pilot carbon trading policies have a favorable impact on UR, and the market mechanism of carbon emissions has a heterogeneous cause influence on UR. The impact of pilot carbon trading policies on UR varies according to the respective moderating effects of institutional factors, green technology innovation, industrial structure rationalization, and output effects.
Towards sustainable transport: quantifying and mitigating pollutant emissions from heavy-duty diesel trucks in Northeast China
Authors: Li Na , Gao Chengkang , Ba Qiao , You Huan , Zhang Xinhong
Published: July 2023

Heavy-duty diesel trucks (HDDTs) have caused serious environmental pollution in China. Accurate estimation of their pollutant emission characteristics is essential to reduce emissions and associated environmental and public health impacts. We developed localized emission factors and a high-resolution emission inventory of HDDTs in Northeast China, based on on-board test, Guidebook and international vehicle emission (IVE) model. The results show that the total emissions of CO, NO, NO2 and PM from HDDTs in Northeast China in 2020 were 172.2 kt, 531.5 kt, 11.2 kt and 921.4 t, respectively. In terms of spatial distribution, emissions decreased from the city center to the city fringe. Temporally, the NOx emission variation curves of different types of roads presented a "single-peak" emission characteristic, which was different from the peak of traffic flow. We further developed three emission reduction scenarios to analyze the pollution reduction under different policies. Scenario analysis shows that elimination of HDDTs that follow the old China III emission standard and installing tailpipe treatment devices are the most effective pollutant reduction measure. The reduction percentages for CO, NO, NO2 and PM ranged from 62.9–83.89%. The results of our study could inform policymakers to devise feasible strategies to reduce vehicle pollution in Northeast China.