bluuebunny/crossref_metadata_2025 huggingface dataset:
Familles dans la tourmente de la répression politique en Guinée (1958-1984)
Authors: Pauthier Céline
Published: January 2022

Dans la Guinée révolutionnaire de Sékou Touré (1958-1984), la rhétorique du complot est omniprésente pour dénoncer des manœuvres impérialistes menées avec la complicité de supposés opposants intérieurs. Cet article envisage les violences physiques et psychologiques infligées à ces derniers en partant de leur expérience carcérale. La répression suscite des déchirements intimes : meurtrissure physique, intrusion dans le for intérieur, atteinte aux masculinités et emprise sur la conjugalité, fragilisation des liens familiaux et amicaux. Le basculement des accusés dans l’infamie a des effets sur plusieurs générations, et l’historien·ne doit tenir compte de ces enjeux mémoriels dans sa démarche d’enquête et d’analyse.
Jeu de miroirs : exposer l’art étranger, fabriquer une politique visuelle française
Authors: Rizzi Elena Maria Rita
Published: January 2022

Cet article analyse la politique d’exposition et d’acquisition du musée des Écoles étrangères, connues sous le nom du Jeu de Paume, durant l’entre-deux-guerres. Il s’agit tout particulièrement de saisir l’imaginaire convoqué par les œuvres d’art d’étranger exposées au musée. Par le biais d’un jeu de miroirs, l’imaginaire créé évoque des enjeux propres au pays d’accueil, en l’occurrence la France, et contribue ainsi à la mise en œuvre d’une politique visuelle pour la République, française qui aboutit, au cours des années 1930, à l’élaboration d’une identité esthétique pour la République, fondée sur l’assimilation de l’œuvre des artistes étrangers dans une vision française de l’art moderne international.
Reconstruire l’histoire nationale dans le Liban d’après-guerre
Authors: Raymond Candice , Noûs Camille
Published: January 2022

Cet article envisage comment, à la sortie de la guerre du Liban (1975-1990), les historiens du pays ont été collectivement mobilisés dans différents dispositifs historiographiques pour traduire la prescription politique issue de l’accord de paix de Taëf – (re)construire un récit historique consensuel à des fins d’unification nationale sur la base d’un nouveau compromis politique. Il examine comment trois de ces dispositifs expriment, par leur montage même, leur ingénierie sociale et leurs choix de méthode, trois conceptions différentes de la manière selon laquelle procéder à l’unification historiographique de la nation libanaise, où des modalités particulières de prise en charge d’un principe de représentation communautaire s’articulent à une certaine logique de production et d’organisation du discours historique.
Conformal $ \eta $-Ricci solitons within the framework of indefinite Kenmotsu manifolds
Authors: Li Yanlin ,   School of Mathematics, Hangzhou Normal University, Hangzhou, 311121, China, Ganguly Dipen , Dey Santu , Bhattacharyya Arindam ,   Department of Mathematics, Jadavpur University, Kolkata 700032, India,   Department of Mathematics, Bidhan Chandra College, Asansol-4, West Bengal 713304, India
Published: January 2022

The present paper is to deliberate the class of $ \epsilon $-Kenmotsu manifolds which admits conformal $ \eta $-Ricci soliton. Here, we study some special types of Ricci tensor in connection with the conformal $ \eta $-Ricci soliton of $ \epsilon $-Kenmotsu manifolds. Moving further, we investigate some curvature conditions admitting conformal $ \eta $-Ricci solitons on $ \epsilon $-Kenmotsu manifolds. Next, we consider gradient conformal $ \eta $-Ricci solitons and we present a characterization of the potential function. Finally, we develop an illustrative example for the existence of conformal $ \eta $-Ricci soliton on $ \epsilon $-Kenmotsu manifold.
The hunting cooperation of a predator under two prey's competition and fear-effect in the prey-predator fractional-order model
Authors: Yousef Ali ,   Department of mathematics, Kuwait College of Science and Technology, 2723 Kuwait City, Kuwait, Thirthar Ashraf Adnan , Alaoui Abdesslem Larmani , Panja Prabir , Abdeljawad Thabet ,   Department of Studies and Planning, University of Fallujah, Anbar, Iraq,   Moulay Ismail university, FST Errachidia, MAIS Laboratory, MAMCS Group, Morocco,   Department of Applied Science, Haldia Institute of Technology, Purba Midnapore-721657, West Bengal, India,   Department of Mathematics and Sciences, Prince Sultan University, P.O. Box 66833, Riyadh 11586, Saudi Arabia,   Department of Medical Research, China Medical University, Taichung 40402, Taiwan
Published: January 2022

This paper investigates a fractional-order mathematical model of predator-prey interaction in the ecology considering the fear of the prey, which is generated in addition by competition of two prey species, to the predator that is in cooperation with its species to hunt the preys. At first, we show that the system has non-negative solutions. The existence and uniqueness of the established fractional-order differential equation system were proven using the Lipschitz Criteria. In applying the theory of Routh-Hurwitz Criteria, we determine the stability of the equilibria based on specific conditions. The discretization of the fractional-order system provides us information to show that the system undergoes Neimark-Sacker Bifurcation. In the end, a series of numerical simulations are conducted to verify the theoretical part of the study and authenticate the effect of fear and fractional order on our model's behavior.
The Networked Storyteller and Her Digital Tale: Film Festivals and Ann Hui’s 'My Way'
Authors: Marchetti Gina
Published: January 2022

In cooperation with China’s Youku online channel, the Hong Kong International Film Festival Society commissioned Ann Hui to make a short film, My Way, to be part of an omnibus production, Beautiful 2012. In order to be considered for this commission, Hui needed to be acknowledged at international film festivals and be a recognized auteur known in the Asian region and beyond. Without Hui’s festival credentials and the reputation of the other directors in the curated production, the collected shorts would have little appeal to other programmers and distributors. Although she has famously resisted the label of “film auteur” in the past, Ann Hui undoubtedly stands as the most celebrated female director based in Hong Kong active before and after the establishment of the Hong Kong Special Administrative Region (HKSAR) in 1997.Given the length of her career as well as the impressive critical and scholarly attention her work has garnered, Hui serves as an exemplary case study of how film festivals play a vital role in the career of a Hong Kong female fiction film director. In the case of My Way, the festival circuit permits a specific type of production and digital distribution that enables Hui to craft a network narrative, which places the transition of its protagonist from male to female within a broader community connected through a shared gender identity. By analyzing Ann Hui’s presence at the festivals in Venice and Hong Kong, as well as the link between her festival exposure and her Internet success, My Way offers insight into the circuitous paths women filmmakers follow in order to tell their stories on transnational screens.
Superheroes: The Endgame - Review of Superhero Movies
Authors: Biskind Peter
Published: January 2022

Comic book movies can’t decide whether superheroes are human or posthuman, but either way they have reached a dead end.
Le mythe des lois de saint Óláf et l’invention des lois fondamentales dans la Norvège médiévale
Authors: Davy Gilduin
Published: January 2022

Les lois de saint Óláf, roi de Norvège de 1015 à 1028, forment un lieu commun des sources islandaises et norvégiennes du Moyen Âge. Elles ne se laissent pas aisément saisir cependant, tant elles se situent à la charnière du droit et du mythe. Probablement inventées au cours de la première moitié du xie siècle pour accompagner la légende du saint roi, elles sont devenues, à compter du milieu du siècle suivant, la pierre angulaire du droit norvégien, jusqu’à nourrir l’émergence des lois fondamentales du Royaume de Norvège. Cette étude se propose donc de cerner l’origine et la portée de ce mythe juridique, à l’aube d’un constitutionnalisme naissant.
Un objet en question : la culture matérielle, à propos d’un ouvrage récent
Authors: Martin Pierre
Published: January 2022

Si le concept de « culture matérielle » renvoie de façon générale aux études d’archéologie et d’anthropologie, il n’a guère été défini pas plus qu’il n’a été réellement théorisé. La tenue du colloque de Caen en 2015 (sous la direction de Luc Bourgeois) a conduit à revenir sur les questions historiographiques sous-tendues par cette expression finalement laconique et contradictoire utilisée dans des champs disciplinaires variés. Publiés en 2018, ces actes permettent de s’interroger, à une vaste échelle européenne, sur la genèse des sciences humaines et sociales et leur évolution jusqu’à nos jours.
La Chasse royale – l’image en mouvement et sonore : la peinture murale énigmatique de la chapelle Sainte-Radegonde à Chinon – un essai
Authors: Silva Aurzelle da
Published: January 2022

La peinture murale désignée comme La Chasse royale a suscité beaucoup d’intérêt et de débats depuis sa découverte, grâce à une image montrant cinq cavaliers à cheval, dont deux couronnés en son sein. La composition, qui est sublimée par un sens des couleurs aiguisé et rythmé, par des mouvements et des gestes forts, ainsi qu’une finesse des détails, reste énigmatique et incomprise. Située dans une chapelle troglodyte près du château de Chinon en Indre-et-Loire, alors siège de pouvoir des Plantagenêt, sa datation est estimée entre le milieu et le dernier quart du xii
e siècle, moment de leur dynastie. L’axe de recherche privilégié a été d’identifier les personnages qui y sont représentés et le contexte. Si c’est Henri II qui est normalement dépeint comme le roi à la tête du cortège, c’est le personnage sur l’axe médian de la composition qui intrigue le plus par son geste à la plus forte amplitude tout en se tournant et se penchant en arrière sur son cheval et que l’on identifie le plus souvent comme Aliénor d’Aquitaine elle-même. Au-delà de ces questions d’identité et de contexte, La Chasse royale utilise tous les moyens de la peinture médiévale afin d’inviter le spectateur à se faire sa propre expérience immersive et sensorielle. En effet, la perception médiévale est dynamique et plurielle, faite pour ressentir profondément son expérience entre deux mondes et permettant ainsi d’engager l’imagination et la mémoire, dans un voyage cognitif. À une époque où tous les arts sont liés au point où l’un implique l’autre, la pluralité de la compréhension offre au peintre ou aux peintres la capacité de les mettre en œuvre en rendant une image cinétique, accompagnée de son aspect sonore. L’image nous mène entre les premiers et les arrières plans d’une véritable tapisserie, d’un canevas où s’entrelacent les couleurs, les mouvements et les gestes. Il crée ainsi des relations et des chiasmes entre les personnages, mais également un rythme : celui de leur interaction, celui de leurs gestes, celui du mouvement des cavaliers et de leur monture tout comme celui du son de leur galop. Vue de cette manière, La Chasse royale se montre dans toute sa force, comme un film d’une chorégraphie précise, visuelle et sonore qui, par le tissage de ses interactions, dévoile peut-être un peu plus la complexité de son histoire.
MCDM Approach to Assess Dropping Out of Education by Children
Authors: Mishra Debesh , Satpathy Abhaya Sanatan , Parmar Tejpal Singh , Singhdeo Ashok Kumar
Published: January 2022

A lifelong process to learn new things is education which has a continuous focus on the learners. In the life as well as evolution of mankind, the education plays a significant role through the creation of knowledge, attitudes and awareness among the children as learners for the betterment and sustainable society. In the present study, different significant reasons for dropping out of education by the children in the province of Odisha in India were found through literature and experts’ opinions. Then, the “Step Wise Assessment and Ratio Analysis (SWARA)” method was utilized to rank these significant reasons based on their preferences.
Computer Vision and IoT-Based Automated Hydroponic Farms in Urban Areas
Authors: Sowmya B. J.  , Seema S.  , Chetan Gowda H. R.  , Raghu Aditya , Shastry Ajay O. , Nikith O. H.  , Srinivasa K. G.
Published: January 2022

As the populace increments and characteristic assets decline, the capacity to serve humankind with an adequate measure of nourishment turns out to be progressively troublesome. The measure of rural land diminishes relatively to the expanding populace, along these lines the measure of nourishment delivered will diminish fundamentally, and will be lacking to serve the developing populace. The universal strategies for cultivating won't do the trick sooner. Thus, using modern technology and resources, a method of efficient farming must be introduced and employed in the agricultural field. This report introduces a method of efficient farming using hydroponics. The system is automated and uses sensor data to make decisions to benefit the crops being grown. The system runs on Raspberry PI and Arduino, and utilizes OpenCV. With our system we hope to solve the potential food crisis and give everyone access to fresh produce all year round.
Promotion of Sustainable Marketing
Authors: Mandal Pratap Chandra
Published: January 2022

Companies and businesses operate with the primary objectives of generating revenues and profits for themselves. In the present business scenario, apart from ensuring consumer welfare and achieving excellence in the competition, companies should be sensitive towards the well-being of the society at large and towards creating and maintaining a sustainable society and physical environment for the present and future generations. Both consumers and businesses should appreciate consumerism and environmentalism. Companies should be sensitive towards the adverse effects of business activities on the environment and realize their responsibilities towards the environment. They adopt a number of initiatives and sustainability visions to ensure creating a sustainable society for the present and future generations. The study will make all the stakeholders understand the importance of promoting sustainable marketing and their roles and responsibilities towards the society.
A Panorama on the Evolution, Process, and Changes of EIA in India and Its Evaluation Using SOAR Analysis
Authors: Barija Vinay Sagar , Korrai Sirisha , Sabhavath Mohini Rani , Sambhana Yogeswara Rao
Published: January 2022

Economic development and environmental degradation are usually inversely proportional to each other and this can be reversed by endorsing more eco-competent growth policies. Although with the prompt economic growth, the concern of environmental sustainability is still a major challenge for every country. EIA since its inception has been considered as a holistic tool in assessing the potential impacts of developmental projects on the natural environment. EIA in India was first launched in 1994 and since then it has been undergoing a renaissance, and now several developmental projects have to obtain necessary environmental clearance as per the EIA notification 2006. This paper focuses on a critical overview of the evolution, process, and changes. Evaluation of the process using SOAR analysis helps in increasing the transparency and efficacy in the EIA. This research finally concludes by inferring that EIA if exercised properly shall not only ensure a clean and healthy environment but also shall aid the nation in achieving the Sustainable Development Goals (SDG).
Selecting Suitable Students for Jobs Based on Their Capacity
Authors: Phan Hien
Published: January 2022

Nowadays, digital transformation in education is an important and urgent task in most universities. This process brings many benefits to both teacher and student, particularly jobs for graduates. Consequently, how to help a last-year student find a suitable job has become a crucial problem. To advise learner to select a suitable job, we need an insightful analysis of learner capacity. Thus, in this paper, the authors propose a method that uses student knowledge and skills data to choose the best suitable students for a job requirement. Firstly, learner capacity is evaluated by subject marks and activities in school; therefore, both subject and activity are described as the structure of obtainable skills and knowledge. Then, the authors also describe a job requirement as a set of skills and knowledge. In the next step, they calculate the real capacity of the student. Finally, they find students who have the real capacity to meet the job requirement by applying the decision-making model.
The Influences of Technology on Digital Economy Development in Vietnam
Authors: Tan Vu Khanh Ngo , Truong Viet Phuong , Do Truong-Xuan
Published: January 2022

The increases in ICT infrastructure/equipment investment and increased ICT adoption tend to be strongly correlated with economic growth and productivity. However, the digital economy needs more participation of digital government, and the people who run the economy plays an important role. Economy operators/leaders need to be equipped with a sufficiently deep understanding of technology trends and innovation technology to apply digital economy development. Digital technology has significantly changed the speed of operation in the economy. The internet and digital devices are drivers of economic growth. This article analyzes the Vietnam digital economy and society in the context of comparison with ASEAN countries and draws conclusions regarding future development trends.
Multi-Objective Crow Search and Fruit Fly Optimization for Combinatorial Test Case Prioritization
Authors: Gouda Ram , Chandraprakash V.
Published: January 2022

This paper proposes a novel test case prioritization technique, namely multi-objective crow search and fruitfly optimization (MOCSFO) for test case prioritization. The proposed MOCSFO is designed by integrating crow search algorithm (CSA) and chaotic fruitfly optimization algorithm (CFOA). The optimal test cases are selected based on newly modelled fitness function, which consist of two parameters, namely average percentage of combinatorial coverage (APCC) and normalized average of the percentage of faults detected (NAPFD). The test case to be selected is decided using a searching criterion or fitness based on sequential weighed coverage size. Accordingly, the effective searching criterion is formulated to determine the optimal test cases based on the constraints. The experimentation of the proposed MOCSFO method is performed by considering the performance metrics, like NAPFD and APCC. The proposed MOCSFO outperformed the existing methods with enhanced NAPFD of 0.7, and APCC of 0.837.
TNF Receptor–Associated Factor 5 Limits IL-27 Receptor Signaling in CD4+ T Lymphocytes
Authors: Kawahara Eigo , Azuma Mitsuki , Nagashima Hiroyuki , Omori Koki , Akiyama Sho , Fujimori Yuka , Oishi Mayu , Shibui Nagito , Kawaguchi Kosuke , Morita Masashi , Okuyama Yuko , Ishii Naoto , So Takanori
Published: January 2022

TNF receptor–associated factor 5 (TRAF5) restrains early signaling activity of the IL-6 receptor in naive CD4+ T cells by interacting with the shared gp130 chain, although TRAF5 was initially discovered as a cytoplasmic adaptor protein to activate signaling mediated by TNF receptor family molecules. This leads to the question of whether TRAF5 limits signaling via the receptor for IL-27, which is composed of gp130 and WSX-1. The aim of this study is to clarify the role of TRAF5 in IL-27 receptor signaling and to understand the differential role of TRAF5 on cytokine receptor signaling. We found that Traf5−/− CD4+ T cells displayed significantly higher levels of phosphorylated STAT1 and STAT-regulated genes Socs3 and Tbx21, as early as 1 h after IL-27 exposure when compared with Traf5+/+ CD4+ T cells. Upon IL-27 and TCR signals, the Traf5 deficiency significantly increased the induction of IL-10 and promoted the proliferation of CD4+ T cells. Traf5−/− mice injected with IL-27 displayed significantly enhanced delayed-type hypersensitivity responses, demonstrating that TRAF5 works as a negative regulator for IL-27 receptor signaling. In contrast, IL-2 and proliferation mediated by glucocorticoid-induced TNF receptor–related protein (GITR) and TCR signals were significantly decreased in Traf5−/− CD4+ T cells, confirming that TRAF5 works as a positive regulator for cosignaling via GITR. Collectively, our results demonstrate that TRAF5 reciprocally controls signals mediated by the IL-27 receptor and GITR in CD4+ T cells and suggest that the regulatory activity of TRAF5 in gp130 is distinct from that in TNF receptor family molecules in a T cell.
Development and optimization of Benjakul microemulsion formulations for enhancing topical anti-inflammatory effect and delivery
Authors: Kuropakornpong Pranporn , Itharat Arunporn , Ooraikul Buncha , Loebenberg Raimar , Davies Neal M.
Published: January 2022

Background and purpose:

Benjakul (BJK) is a combination of five botanical herbal constituents widely used in Thai traditional medicine as an anti-inflammatory remedy. This study aimed to develop a novel topical microemulsion containing BJK for clinical use.

Experimental approach:

The microemulsions were produced by a phase inversion temperature (PIT) methodology. Physicochemical properties and stability were evaluated to determine an optimal formula. The stable BJK-loaded microemulsion formulas were then subjected to in vitro studies for their anti-inflammatory activity, skin cell toxicity, drug permeation, and stability.

Finding/Results:

Two novel formulations containing isopropyl myristate (ME1-BJK and ME2-BJK) passed the compendial stability test. BJK constituents were completely dissolved in the oil phase and incorporated into the microemulsion base Transcutol® and Labrasol® avoiding the use of alcohol, both microemulsion formulations demonstrated high anti-inflammatory activity with IC50 values of 3.41 ± 0.36 and 3.95 ± 1.73 μg/mL, respectively. However, dissolution of ME1-BJK showed a superior release profile through both lipophilic and hydrophilic membranes with the highest accumulated amount at 4 h of 25.13% and 38.06%, respectively. All tested formulations of BJK extract demonstrated no apparent skin cell toxicity at concentrations up to 50 μg/mL. After six-month storage under accelerated conditions, there were no significant changes in anti-inflammatory activity.

Conclusions and implications:

A novel and stable BJK-loaded microemulsion formulation was successfully developed with excellent release and stability properties. Further clinical research to evaluate pain reduction, edema, and skin irritation using this formulation in animal models is ongoing.
Locomotor and histological changes in a cuprizone-induced animal model of multiple sclerosis
Authors: Mitra Nilesh Kumar , Singh Nermesh Singh A/L Gurdib , Wadingasafi Nurul Ain Najihah Binti , Chellian Jestin
Published: January 2022

Background and purpose:

Fingolimod is a sphingosine 1-phosphate receptor modulator used to treat multiple sclerosis (MS). Alpha-tocopherol (AT) has been found to improve motor function in an animal model of MS. In the present study, the effects of AT and fingolimod on the locomotor function and histological evidence of demyelination were compared in a cuprizone-induced rat model of MS.

Experimental approach:

Female Sprague-Dawley rats (8 weeks) were fed with 0.2% (w/w) cuprizone diet for 5 weeks followed by intraperitoneal injections of fingolimod (3 mg/Kg; group F, n = 10) and alpha- tocopherol (100 mg/Kg; group A, n = 10). Vehicle-treated rats (group V, n = 10) were treated intraperitoneally with 1% ethanol in saline on weeks 6 and 7. Open field and beam walking tests were carried out every 10 days. The mean area of demyelination in the corpus callosum was quantified using Luxol fast blue stained histological sections of the forebrain.

Findings/Results:

The mean speed of movement was increased by 54% and 50% in groups F and A compared to group V. Total distance moved was increased by 61% and 52.7% in groups F and A compared to group V. Mean time to walk the beam was reduced in group A by 52% compared to group V. Mean frequency of crossing lines from the inner squares to outer squares was reduced in groups A and F compared to group V. Mean area of demyelination in corpus callosum showed 62% reduction in group A compared to group V.

Conclusion and implications:

Both fingolimod and AT treatments improved the locomotor function. However, AT treatment reduced the areas of demyelination in higher proportion and improved motor coordination and exploratory behavior.
In vitro evaluation of the pogostone effects on the expression of PTEN and DACT1 tumor suppressor genes, cell cycle, and apoptosis in ovarian cancer cell line
Authors: Homayoun Mansour , Sajedi Nayereh , Soleimani Mitra
Published: January 2022

Background and purpose:

Ovarian cancer is one of the most dangerous cancers among women. Pogostone has anticancer effects and is rich in polyphenol compounds. In the present study, we investigated the effects of pogostone on ovarian cancer cell lines (OVCAR-3).

Experimental approach:

OVCAR-3 cells were treated with pogostone at IC50(90 μg/mL) for 24 and 48 h. Cell viability and apoptotic rate in the cells were measured using MTT assay and flow cytometry. Real-time PCR was used to determine the expression of genes involved in the cell cycle and apoptosis. The expression of caspase-3 (CASP3) protein was evaluated by the CASP3 assay.

Findings/Results:

Treatment of OVCAR-3 cells with pogostone increased the expression levels of phosphatase and tensin homologue deleted on chromosome ten (PTEN) and Dapper antagonist of catenin-1 (DACT1) tumor suppressor genes, as well as the apoptotic genes CASPs3, 8, and 9. Moreover, the ratio of the expressed BCL2 associated X (BAX)/BCl2 genes, as pro- and anti-apoptotic genes, was increased. The expression levels of the genes related to the cell cycle progression including cyclin D1 (CCND1) and cyclin- dependent kinase 4 (CDK4) were inhibited. The data obtained from flow cytometry indicated that pogostone induced cell apoptosis in 24 and 48 pogostone groups. The CASP3 colorimetric assay revealed that pogostone increased the expression of CASP3 protein in the treated groups.

Conclusion and implication:

Pogostone, by inducing the expression of PTEN and DACT1 tumor suppressor genes and regulation of downstream genes may decrease cell proliferation and increase the rate of apoptosis in OVCAR-3.
In silico screening and molecular dynamics simulations toward new human papillomavirus 16 type inhibitors
Authors: Razzaghi-Asl Nima , Mirzayi Sahar , Mahnam Karim , Adhami Vahed , Sepehri Saghi
Published: January 2022

Background and purpose:

Human papillomavirus (HPV) is known as the main reason for cervical cancer. According to carcinogenic risk, HPV can be located into two classes, counting the low-risk virus, which is the main cause of genital warts and low-grade cervical epithelial lesions. HPV-16 is one of the high-risk HPV subtypes in the spectrum of cervical diseases.

Experimental approach:

The PubChem database was screened in order to identify potential anti-HPV hits followed by ADMET predictions. Then, molecular docking was performed to improve the accuracy of screening and also to find the details of the interactions of the hit compounds with the active site. Finally, molecular dynamic (MD) simulations and free binding energy on top-ranked structures CID_73212812, CID_91059286, CID_69838075, cidofovir, and jaceosidin were carried out with protein to compute the interaction energies and stability of the top-ranked compounds at the active site.

Findings/Results:

Based on molecular docking studies, three compounds including CID_73212812, CID_91059286, and CID_69838075 exhibited the best results among compounds against the E6 protein of HPV-16. Furthermore, RMSD, RMSF, hydrogen binds, Rg, and energy analysis during MD simulation certainly indicated the stable binding of selected compounds with E6 protein of HPV-16 active site.

Conclusion and implications:

Docking and MD results revealed that hydrophobic contacts and optimum hydrogen bonds were determinant factors in the interactions of hits and the E6 protein of HPV-16. In addition, the binding energy portions exposed that Van der Waals and non-polar interactions were fundamental factors in the molecule binding.
Royal jelly protects dichlorvos liver-induced injury in male Wistar rats
Authors: Jalili Cyrus , Farzaei Mohammad Hossein , Rashidi Iraj , Mohammadnezamian Ayda , Ghanbari Ali
Published: January 2022

Background and purpose:

Dichlorvos, an organophosphate insecticide, induces side effects on normal tissues. On the other hand, Royal jelly (RJ) with antioxidant activities has many medical benefits including liver toxicity. In this study, we investigated the role of RJ in improving dichlorvos adverse impact on the liver of male rats.

Experimental approach:

Forty-eight male rats were randomly divided into 8 groups (n = 6); receiving by gavage normal saline (0.09%), dichlorvos (4 mg/kg/day), RJ (50, 100, 150 mg/kg/day; RJ 1, 2, 3) or dichlorvos + RJs, daily for 28 consecutive days. At the end of experiments, histopathology alterations, apoptosis induction, and biochemical factors related to the liver were evaluated.

Findings/Results:

There was a significant reduction in the number of hepatocytes and total antioxidant capacity (TAC) levels in the dichlorvos group compared to the control group, whereas these parameters in the dichlorvos + RJs groups, were significantly increased compared to the dichlorvos group. Central vein diameter, liver enzymes (aspartate transaminase, alanine transaminase, and alkaline phosphatase) serum levels of nitric oxide, and apoptotic index were significantly higher in the dichlorvos group than in the control, while these parameters were decreased in the dichlorvos + RJs groups versus the dichlorvos group.

Conclusion and implications:

RJ at 50 mg/kg protected dichlorvos-induced liver damage in rats. Dichlorvos- hepatitis mechanism could be oxidative induction as long as antioxidant reduction leads to apoptosis in this organ, while RJ due to its antioxidant potential suppresses this hazardous cellular and molecular process.
Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients
Authors: Rad Nikoo Roustaei , Movahedian Ahmad , Feizi Awat , Aminorroaya Ashraf , Aarabi Mohammad Hosein
Published: January 2022

Background and purpose:

Since the critical role of oxidative stress in the pathogenesis and complications of type 2 diabetes mellitus (T2DM) has been proven, antioxidant therapy is considered an applicable strategy to control T2DM development. This study aimed at evaluating the effect of astaxanthin (AST) supplementation combined with metformin on oxidative indices and antioxidant defenses in T2DM patients.

Experimental approach:

In this randomized, double-blind placebo-controlled trial, 50 T2DM subjects receiving metformin were supplemented with 10 mg/day AST or placebo for 12 weeks. Malondialdehyde concentration and serum total antioxidant capacity (TAC) were assessed as oxidative indices. We also evaluated NF-E2-related factor2 (Nrf2) as the most critical transcription factor of antioxidant defense. Moreover, the activity of antioxidant enzymes, superoxide dismutase (SOD), and catalase were calculated.

Findings/Results:

AST supplementation-metformin combination caused a significant increase in SOD and catalase activities, as well as inducing Nrf2 protein expression compared to the placebo group. Significant changes in serum malondialdehyde and TAC between the AST group and placebo group after supplementation were not observed, although a significant increase was observed in TAC within the AST group after supplementation (32.67 ± 6.73) to before (25.86 ± 5.98). These results remained without change after adjustment for potential confounders.

Conclusion and implications:

Our study demonstrated that AST supplementation controlled oxidative stress through a synergistic effect with metformin and ameliorated overall antioxidant capacity by inducing Nrf2 transcription factor and activating SOD and catalase in T2DM patients. As a result, AST and metformin combination therapy can be considered beneficial in modifying oxidative stress and preventing T2DM complications.
Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility
Authors: Li You-Zhu , Li Na , Liu Wen-Sheng , Sha Yan-Wei , Wu Rong-Feng , Tang Ya-Ling , Zhu Xing-Shen , Wei Xiao-Li , Zhang Xiao-Ya , Wang Yi-Feng , Lu Zhong-Xian , Zhang Fu-Xing
Published: January 2022

Acephalic spermatozoa syndrome is a rare type of teratozoospermia that severely impairs the reproductive ability of male patients, and genetic defects have been recognized as the main cause of acephalic spermatozoa syndrome. Spermatogenesis and centriole-associated 1 like (SPATC1L) is indispensable for maintaining the integrity of sperm head-to-tail connections in mice, but its roles in human sperm and early embryonic development remain largely unknown. Herein, we conducted whole-exome sequencing (WES) of 22 infertile men with acephalic spermatozoa syndrome. An in silico analysis of the candidate variants was conducted, and WES data analysis was performed using another cohort consisting of 34 patients with acephalic spermatozoa syndrome and 25 control subjects with proven fertility. We identified biallelic mutations in SPATC1L (c.910C>T:p.Arg304Cys and c.994G>T:p.Glu332X) from a patient whose sperm displayed complete acephalia. Both SPATC1L variants are rare and deleterious. SPATC1L is mainly expressed at the head–tail junction of elongating spermatids. Plasmids containing pathogenic variants decreased the level of SPATC1L in vitro. Moreover, none of the patient's four attempts at intracytoplasmic sperm injection (ICSI) resulted in a transplantable embryo, which suggests that SPATC1L defects might affect early embryonic development. In conclusion, this study provides the first identification of SPATC1L as a novel gene for human acephalic spermatozoa syndrome. Furthermore, WES might be applied for patients with acephalic spermatozoa syndrome who exhibit reiterative ICSI failures.
Intrauterine insemination with donor sperm
Authors: Cardey-Lefort Marie , Ducrocq Berengere , Uk Audrey , Behal Helen , Barbotin Anne-Laure , Robin Geoffroy
Published: January 2022

Intrauterine insemination with donor sperm (IUI-D) is an assisted reproductive technology (ART) offered to couples with definitive male infertility or risk of genetic disease transmission. Here, we sought to evaluate our practice in IUI-D and identify factors that influenced the success rate. We performed a retrospective, single-center study of all IUI-D procedures performed at Lille University Medical Center (Lille, France) between January 1, 2007, and December 31, 2017. Single and multivariate analyses with a mixed logistic model were used to identify factors associated with clinical pregnancies and live births. We included 322 couples and 1179 IUI-D procedures. The clinical pregnancy rate was 23.5%, and the live birth rate was 18.9% per IUI-D. In a multivariate analysis, the women's age was negatively associated with the live birth rate. The number of motile spermatozoa inseminated was the only factor associated with both clinical pregnancies and live births, with a chosen threshold of 0.75 million. The clinical pregnancy and live birth rates were, respectively, 17.3% and 13.0% below the number of motile spermatozoa inseminated threshold and 25.9% and 21.0% at or above the threshold (all P = 0.005). The number of motile spermatozoa inseminated was the only factor that significantly influenced both pregnancies and live-birth rates after IUI-D. Indeed, below a threshold of 0.75 million motile spermatozoa inseminated, those rates were significantly lower. Application of this number of motile spermatozoa inseminated threshold may help centers to allocate donations more effectively while maintaining reasonable waiting times for patients.
Corrective Exercises or Ergonomic Principles for Workers with Low Back Pain
Authors: Safaeian Alireza , Shahsanai Armindokht , Kiyany Farzaneh
Published: January 2022

Introduction:

Work-related musculoskeletal disorders (WRMSD) are considered the main cause of occupational diseases. Health care workers, nursing assistants, and service forces that perform manual labor are the most vulnerable to musculoskeletal disorders, especially low back pain, due to the nature of their jobs. The purpose of this study was to compare the effectiveness of corrective exercise training to ergonomic principles training on low back pain in nursing assistants and service forces.

Methods:

A nonrandomized clinical trial study was done on 75 staff (nursing assistants and service forces) with low back pain. The participants were divided into three groups: corrective exercise training, ergonomic principles training, and control group. Pain intensity and disability questionnaires were completed before and after 8 weeks of intervention by each group and analyzed.

Results:

The mean intensity of pain after intervention in corrective exercises group (3.8 ± 1.5) was markedly less than the ergonomic group (4.7 ± 1.4) and control group (5.5 ± 1.7) (P = 0.001). The mean disability score after intervention in the corrective exercises group (17.3 ± 9.6) was significantly less than the ergonomic group (21.8 ± 12.6) and control group (25.3 ± 11.2) (P < 0.001).

Conclusion:

While corrective exercises training and ergonomic principles training both have a significant effect on reducing the severity of pain and disability caused by low back pain, corrective exercises training is more effective than ergonomic principle training.
Musculoskeletal Pain and Risk Factors Associated with Smartphone Use in University Students
Authors: Walankar Prachita P. , Kemkar Manasi , Govekar Aniket , Dhanwada Agasthya
Published: January 2022

Background:

Smartphone has become a very popular necessity among students. An individual has to look at their phone's small monitor and perform repetitive movements in an awkward posture for a prolonged duration.

Objectives:

To assess the prevalence of musculoskeletal pain and associated risk factors in university students because of smartphone usage.

Subjects and Methods:

A cross-sectional study was conducted with 2000 university students using a semi-structured questionnaire comprising demographic profile, smartphone usage characteristics, presence of musculoskeletal pain, and specific area of pain according to the body region.

Results:

Among the 2000 students, 44.05% reported musculoskeletal pain. The most common sites of pain were the neck (34.2%), thumb (17.45%), lower back (16.7%), and elbow (16.6%). There was an association between prevalence of musculoskeletal pain with the size of the smartphone (P = 0.005), the predominant purpose of smartphone usage (P = 0.002), position preferred while using smartphone (P = 0.000), and the level at which smartphone is held during usage (P = 0.05). Logistic regression analysis revealed that the strongest predictor of musculoskeletal pain was the size of the smartphone.

Conclusion:

The study reported that the prevalence of pain in smartphone users is high with common sites being neck, thumb, and lower back region. Also, the size of the smartphone had a significant association with musculoskeletal pain.
Klippel–Trenaunay syndrome with Chiari I malformation: A rare correlation with literature review
Authors: Datta Debajyoti , Sekar Arunkumar , Sahu Rabi Narayan
Published: January 2022

Abstract

Klippel–Trenaunay syndrome (KTS) is characterized by localized vascular naevus, congenital or early infantile varicosities, and soft tissue or bony hypertrophy. It was been described to be associated with hemimegalencephaly and Chiari I malformation in isolation. Here we present a case of a child who presented with KTS associated with both hemimegalencephaly and Chiari I malformation. The clinical presentation of the child and the likely pathogenesis of association with Chiari I malformation in KTS are discussed. The overall management of KTS with Chiari 1 malformation is reviewed.
Fast channel congenital myesthenic syndrome: Reporting two cases with mutation of CHRNE gene and short review
Authors: Rahman Md Mizanur , Fatema Kanij
Published: January 2022

Abstract

Congenital myasthenic syndromes (CMSs) are hereditary neuromuscular disorders. Fast channel CMSs are a rare entity characterized by onset at birth or early infancy, easy fatigability, ptosis, proximal muscle weakness, ophthalmoplegia, etc. A positive family history may be present. Genetic mutation related to fast channel CMSs is diverse; there is variability of phenotype with genotype. CHRNE is the most common gene associated with this disorder in which post-synaptic acetylcholine receptor (AChR) is affected. Diagnosis is done by repetitive nerve stimulation (RNS) test and genetic test by excluding autoimmune cause. Most of the cases are responsive to pyridostigmine. Here we report two cases—siblings and male—with early onset of disease with typical clinical feature. The RNS test was positive, and AChR autoantibody was negative. The final diagnosis was made by next generation sequencing in which both the cases had pathogenic mutation of the CHRNE gene.
An infant with posterior fossa hemangioma with aortic stenosis: Case report and review of the literature
Authors: Senol Yigit Can , Daglioglu Ergun , Aydogdu Basaran Ozge , Belen Ahmet Deniz
Published: January 2022

Abstract

We presented a unique case of infantile type hemangioma corresponding with aortic stenosis. Therefore, we accepted this case as a PHACES syndrome. This case will be the 4th case of the literature. The most remarkable feature of PHACES syndrome is infantile hemangioma, but abnormalities in the arteries which are not obvious on the clinical examination have considerable potential morbidity. We have certain diagnosis with pathology and no conflicts of interest disclosure.
Concurrent Guillain-Barré Syndrome and Acute Disseminated Encephalomyelitis in a Child
Authors: Fatema Kanij , Rahman Md Mizanur , Akhter Shaheen
Published: January 2022

Guillain-Barré syndrome (GBS) and acute disseminated encephalomyelitis (ADEM) are postinfectious, inflammatory, and neurological disorders involving the peripheral and central nervous system, respectively. Although the clinical features are distinct, they share a common pathogenesis. Both the disorders are not uncommon in children. Concurrent GBS and ADEM occurring simultaneously is a rare entity. We are reporting a case of a 5-year-old boy presenting with acute-onset ascending paralysis with irritability, hyperreflexia, and positive Babinski sign. This patient was diagnosed as having both GBS and ADEM. The CSF albumin-cytological disassociation, electrophysiological diagnosis, and MRI of brain supported the concurrent present of the two disorders.
A Novel method of airway management in a neonate with a large occipital encephalocoele
Authors: Praveen S Mano , Shetty N Anita , Devalkar S Priti , Sakrikar R Gayatri , Paliwal U Shashank , Hemantkumar C Indrani
Published: January 2022

Abstract

Encephalocoeles are one of the rarest open neural tube defects that usually present at birth with a large occipital or frontoethmoidal swelling and require surgical correction in the neonatal period. Airway management in a neonate with a large occipital encephalocoele is difficult due to inadequate neck extension and positioning difficulties.
Acute Postoperative Pancreatitis after Craniotomy for Excision of Insular Glioma: A Classic Case of Whodunit
Authors: Ruparelia Jigish , Singh Gosal Jaskaran , Kumari Kamlesh , Varshney Vaibhav Kumar , Sureka Binit , Bhaskar Suryanarayanan , Kaur Manbir
Published: January 2022

Abstract

Acute pancreatitis (AP) has been reported following abdominal surgeries. There are rare reports of AP developing following operations remote to the pancreas. We report a case of postoperative AP following craniotomy for tumor excision. A 15-year-old girl presented with a history of one episode of seizure, headache, and recent left-sided hemiparesis. She was found to have a right frontal glial lesion with extensive white matter tract edema. Craniotomy and excision was done. On the first postoperative day, she developed acute abdominal pain, with guarding and tenderness on examination. Radiological and biochemical evidence for AP was found. AP is a rare, but life-threatening complication. A number of drugs commonly used in neurosurgical practice can cause AP, which include steroids, antiepileptics, and propofol which are extensively used during surgery and for sedation in the intensive care area.
Infantile spinal extradural schwannoma: A rare occurrence
Authors: Diyora Batuk , Dhall Gagan , Patel Mehool , Devani Kavin , Chhajed Rahul , Dubey Ashish
Published: January 2022

Abstract

In comparison to spinal intradural and intradural–extradural schwannoma, purely extradural schwannoma is rare. There is no clearcut consensus about the origin of these tumors. There are very few cases reported in the pediatric population. On literature search, we have not found a similar case in the infantile age group. We report a case of purely spinal extradural schwannoma in a 5-month-male child who presented with paraparesis. Magnetic resonance imaging scan revealed a 7.5×2.5×1.2 cm size contrast-enhancing spinal extradural mass lesion extending from D4 to D10 vertebral level. The child underwent thoracic laminotomy, and the spinal extradural mass lesion was completely excised. Histopathological examination of the specimen revealed schwannoma. The child recovered well in the post-operative period. At 1 year follow-up, he has completely regained his power in both lower limbs.
En plaque tuberculoma of the dura with extracranial extension in an adolescent mimicking an aggressive en plaque meningioma
Authors: Krishnan Prasad , Ghosh Nabanita , Sanyal Sugat
Published: January 2022

Abstract

Tuberculosis has been called the “great mimic.” We present an uncommon case of an en plaque dural tuberculoma in an adolescent that was both causing mass effect intracranially and eroding the skull and extending extracranially mimicking an aggressive meningioma and discuss the theories about the origin of dural tuberculomas, enumerate common radiological differential diagnosis and mention ways that may help to identify the disease without recourse to surgery.
Intravitreal aflibercept combined with transpupillary thermotherapy in the treatment of refractory macular edema due to primary uveal melanoma
Authors: Huang Yu-Te , Lin Chun-Ju , Hsia Ning-Yi , Lai Chun-Ting , Bair Henry , Tsai Yi-Yu
Published: January 2022

We reported a 74 year old Asian female with a uveal tumor with subretinal fluid (SRF) and cystoid macula edema. Since she declined biopsy, multimodal imaging study was performed, including fundus photography, ultrasonography, optical coherence tomography, fluorescein angiography, and magnetic resonance imaging. Uveal melanoma was diagnosed. However, despite aggressive treatment with TTT and three adjuvant intravitreal bevacizumab doses, SRF, and cystoid macula edema were persistent. Therefore, aflibercept was administered, resulting in anatomical and functional improvement within 1 month, which lasted for 12 months. Aflibercept offered great efficacy in improving refractory macular edema in this case of primary uveal melanoma. Multimodal imaging can provide us with more diagnostic clues in differentiating the nature of intraocular tumors.