bluuebunny/crossref_metadata_2025 huggingface dataset:
Sexo e deficiência
Authors: Mendes Marlon Jose Gavlik , Denari Fátima Elisabeth
Published: October 2023

O trabalho com temas da educação sexual com pessoas com deficiência intelectual é algo necessário, contudo, muitos profissionais que atendem esse público podem considerar desafiador. O objetivo desta pesquisa foi explorar os discursos sobre deficiência intelectual, sexo e sexualidade de professoras atuantes na educação especial. Para tal, foram realizadas entrevistas semiestruturadas com cinco professoras da área. Este material foi analisado qualitativamente a partir da genealogia de Foucault. Os resultados mostraram que as professoras realizam atividades básicas de orientação com seus alunos, evitando temas complexos como violência sexual. A maioria das professoras se espanta com manifestações sexuais de seus discentes, os submetendo a um elaborado sistema de vigilância e controle do corpo. Contatou-se que a educação sexual se concretiza dualmente, em conjunto com a punição e vigilância do corpo. São necessários programas de formação docente para a desconstrução de preconceitos e a elaboração de projetos de educação sexual respeitosos e emancipatórios.
Expression and Prognostic Significance of Ferroptosis-related Proteins
SLC7A11 and GPX4 in Renal Cell Carcinoma
Authors: Ren Zongtao , Zhang Xiaoyu , Han Jingya
Published: October 2023

Background::

The ferroptosis inhibitory gene solute carrier family 7 member 11
(SLC7A11) and glutathione peroxidase 4 (GPX4) inhibit ferroptosis in carcinoma cells. However,
whether SLC7A11 and GPX4 serve as an oncogene in renal cell carcinoma (RCC) remains unclear.

Methods::

Immunohistochemistry (IHC) assays were performed to assess the expression of
SLC7A11 and GPX4 in human RCC tissues. Clinical-pathological analysis was performed to
explore the correlation between SLC7A11 and GPX4 expression. Kaplan-Meier survival analysis
was performed to characterise the associations between protein expression and patient progressionfree
survival (PFS).

Results::

The upregulation of SLC7A11 and GPX4 was detected by IHC in RCC tissues compared
with that in normal renal tissues. Meanwhile, the expression level of SLC7A11 and GPX4 was
correlated with tumour diameter and distant metastasis (P<0.05). Kaplan-Meier survival analysis
indicated that patients with high SLC7A11 and GPX4 expression levels exhibited worse PFS than
those with low SLC7A11 and GPX4 expression levels (P<0.05).

Conclusion::

The upregulation of SLC7A11 and GPX4 expression was associated with poor
prognosis in patients with RCC. SLC7A11 and GPX4 may serve as diagnostic and prognostic
biomarkers for patients with RCC.
Vegan Diet: A Novel Trend in Healthy Living
Authors: Kamei Gaithaongamliu , Rasane Prasad , Singh Jyoti , Kaur Sawinder , Gunjal Mahendra , Kaur Jaspreet , Gupta Raghav , Mahato Dipendra Kumar , Gurumayum Sushma , Dwivedi Sunil Kumar
Published: October 2023

An entirely animal-free diet that prioritizes natural plant-origin foods such as vegetables,
fruits, whole grains, pulses, and lentils is known as a vegan diet. Lowering persistent diseases
like type-2 diabetes, cardiovascular conditions, cancer, and many others offers numerous positive
health effects. Different aspects of how a vegan diet affects health are studied, and the dietary
pattern is analyzed. Along with the trend of a vegan diet, many people have become aware of the
importance of following a vegan diet, and many do this for health reasons or due to religious beliefs.
A vegan diet has also been seen to positively affect aging. As vegan diet choices are growing,
there are now more options for meat and non-dairy alternatives. Optimization for developing
an alternative vegan food product is necessary to produce the most favorable product quality and
achieve the best. This paper indicates the vegan diet as a whole and how the vegan diet can help
treat chronic diseases. It also reviews vegan products for alternative use and their stance in the
food industry.
Network Pharmacology, Molecular Docking and Experimental Verification
Revealing the Mechanism of Fule Cream against Childhood Atopic
Dermatitis
Authors: Liu Chang , Liu Yuxin , Liu Yi , Guan Jing , Gao Ying , Ou Ling , Qi Yuenan , Lv Xiaoxi , Zhang Jianmin
Published: October 2023

Background:

The Fule Cream (FLC) is an herbal formula widely used for the treatment
of pediatric atopic dermatitis (AD), however, the main active components and functional
mechanisms of FLC remain unclear. This study performed an initial exploration of the potential
acting mechanisms of FLC in childhood AD treatment through analyses of an AD mouse model
using network pharmacology, molecular docking technology, and RNA-seq analysis.

Materials and Methods:

The main bioactive ingredients and potential targets of FLC were collected
from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and
SwissTargetPrediction databases. An herb-compound-target network was built using Cytoscape
3.7.2. The disease targets of pediatric AD were searched in the DisGeNET, Therapeutic Target
Database (TTD), OMIM, DrugBank and GeneCards databases. The overlapping targets between
the active compounds and the disease were imported into the STRING database for the construction
of the protein-protein interaction (PPI) network. Gene Ontology (GO) enrichment and
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the intersection targets
were performed, and molecular docking verification of the core compounds and targets was
then performed using AutoDock Vina 1.1.2. The AD mouse model for experimental verification
was induced by MC903.

Results:

The herb-compound-target network included 415 nodes and 1990 edges. Quercetin,
luteolin, beta-sitosterol, wogonin, ursolic acid, apigenin, stigmasterol, kaempferol, sitogluside
and myricetin were key nodes. The targets with higher degree values were IL-4, IL-10, IL-1α,
IL-1β, TNFα, CXCL8, CCL2, CXCL10, CSF2, and IL-6. GO enrichment and KEGG analyses
illustrated that important biological functions involved response to extracellular stimulus, regulation
of cell adhesion and migration, inflammatory response, cellular response to cytokine
stimulus, and cytokine receptor binding. The signaling pathways in the FLC treatment of pediatric
AD mainly involve the PI3K-Akt signaling pathway, cytokine‒cytokine receptor interaction,
chemokine signaling pathway, TNF signaling pathway, and NF-κB signaling pathway. The
binding energy scores of the compounds and targets indicate a good binding activity. Luteolin,
quercetin, and kaempferol showed a strong binding activity with TNFα and IL-4.

Conclusion:

This study illustrates the main bioactive components and potential mechanisms of
FLC in the treatment of childhood AD, and provides a basis and reference for subsequent exploration.
Investigation on the Microbiological Quality and Fatty Acid Methyl Esters
Composition of Commercially Available Cold-pressed Nigella sativa L. Oil
Authors: Özçakmak Sibel , AlMatar Manaf , Var Işil. , Tekin Ali
Published: October 2023

Background::

Nigella sativa is a traditional plant with several ethno-medicinal activities.
There have been several health advantages associated with Nigella sativa (Ns) L. oil, which has a
high concentration of bioactive compounds.

Method::

This research aimed to examine the fatty acid methyl ester profiles, microbiological profiles,
and aflatoxin profiles of cold-pressed Ns oils acquired from Turkish herbalists. For this, the
fatty acids methyl esters (FAMEs) content and microbiological purity of 10 different Ns oils were
examined.

Results::

The principal FAME components in Ns seed oils were linoleic (C18:2), oleic (C18:1), and
palmitic acid (C16:0), with relative percentages of 34.17-57.54%, 19.41-30.52%, and 7.05-12.54%,
respectively. The quantity of total saturated fatty acids (SFA) in all investigated oils ranged from
11.47 to 18.69%, while the amount of total unsaturated fatty acids ranged from 80.94 to 88.53%. Six
of ten products (0.35-1.49%) were found to contain cis-11 eicosenoic acid, a chemical unique to Ns
oil.

Conclusion::

Although no Aflatoxin was found in any of the samples, Enterobacteriaceae levels were
exceptionally low, and yeast mold concentrations surpassed the Turkish Food Codex's permissible
limit values.
A Critical Review on Various Buffer Layers used to Enhance the
Photovoltaic Performance of Organic Solar Cells
Authors: S. Sreejith , J. Ajayan , Reddy N.V. Uma , M. Manikandan , J.M. Radhika
Published: October 2023

Due to the high need for sustainable energy sources, there has been a tremendous
increase in SC (solar cell) production and research in recent years. Despite the fact that inorganic
SC has led the SC consumer market due to its exceptional efficiency, its expensive and difficult
manufacture method makes it unaffordable. Hence alternative technology for SC has been explored by researchers to overcome the draw backs of inorganic SC fabrication. OSC (organic
solar cell) alternatively known as polymer SC has the advantage of having lightweight, low production cost, and simple device structure. During the last few years, significant attention has
been given in order to overcome the material and technological barriers in OSC devices to make
them commercially viable. Buffer layers play a significant part in improving the power conversion efficiencies in OSCs, thus it is necessary to comprehend the underlying microscopic mechanisms that underlie the advancements in order to support the current qualitative knowledge. In
this review article, we have studied extensively the impact of different BLs (buffer-layer) in
enhancing the PCE (power conversion efficiency) and absorption capabilities of OSCs.
Geometric Feature of DNA Sequences
Authors: Xu Hongjie
Published: October 2023

Background::

The primary goal of molecular phylogenetics is to characterize the similarity/
dissimilarity of DNA sequences. Existing sequence comparison methods with some patented
are mostly alignment-based and remain computationally arduous.

Objective::

In this study, we propose a novel alignment-free approach based on a previous DNA
curve representation without degeneracy.

Method::

The method combines two important geometric elements that describe the global and
local features of the curve, respectively. It allows us to use a 24-dimensional vector called a characterization
vector to numerically characterize a DNA sequence. We then measure the dissimilarity/
similarity of various DNA sequences by the Euclidean distances between their characterization
vectors.

Results::

we compare our approach with other existing algorithms on 4 data sets including
COVID-19, and find that our apporach can produce consistent results and is faster than the
alignment-based methods.

Conclusion::

The method stated in this study, can assist in analyzing biological molecular sequences
efficiently and will be helpful to molecular biologists.
The Impact of HAPPY (Humanity Assurance Protocol in Interventional
Radiotherapy) on the Psychological Well-being of Gynecological Cancer
Patients
Authors: Tagliaferri Luca , Mancini Silvia , Lancellotta Valentina , Dinapoli Loredana , Capocchiano Nikola , Cornacchione Patrizia , Scalise Sara , Autorino Rosa , Campitelli Maura , Colloca Giuseppe Ferdinando , Fionda Bruno , Rovirosa Angeles , Macchia Gabriella , Ferrandina Gabriella , Gambacorta Maria Antonietta
Published: October 2023

Background:

HAPPY (Humanity Assurance Protocol in Interventional Radiotherapy)
reports the necessity for gynecological cancer patients to undergo interventional radiotherapy
(IRT, also called brachytherapy). The present paper has evaluated how some precautions may
improve the psychological well-being of the patients during IRT.

Methods:

Patients with gynecological cancer undergoing IRT-HDR were analyzed. Patients answered
three questionnaires before the IRT procedure (T0) and at the end of IRT (T1): Distress
Thermometer (DT), Numerical Rating Scale for IRT procedure distress (NRS), and Hospital Anxiety
and Depression Scale (HADS). Correlations have been calculated pairwise through pandas.
corrwith with a Pearson algorithm, and the p-values have been calculated through
scipy.stats.pearsonr. Plots have been generated through seaborn and matplotlib. A Wilcoxon test
was used.

Results:

55 patients were selected for this study. The median age of the patients was 64 (range,
39-84) years. 52 patients were with stage I endometrial cancer, whereas 3/3 patients with cervical
cancer had locally advanced stages (IIB-IVA). 26 patients had a high education level (47.3%), and
38 were married or with a partner (69.1%). Only 14/55 (25.45%) patients were working. The
HADS, DT, and NRS averages before the IRT procedure (T0) were 10.2, 3.8, and 4.3, respectively.
After applying the HAPPY protocol, the HADS, DT, and NRS averages after IRT (T1) were
9.4, 3.4, and 2.6, respectively. The Wilcoxon signed rank test analysis showed a significant improvement
in NRS (p < 0.00001) and HADS (p = 0.034). Living with a partner, parents or relatives
was the only parameter statistically significantly associated with better DT pre-IRT (p =
0.04), HADS pre-IRT (p = 0.01), DT post-IRT (p = 0.01), and HADS post-IRT (p = 0.04).

Conclusion:

In our study, the HAPPY protocol was associated with a significant reduction in
patients’ distress, anxiety, and discomfort.
Recent Advances in Combating Acne with Novel Drug Delivery Systems:
A Review
Authors: D'Sa Melroy , Mahadik Shreyash S. , Patel Nrupesh , Nadar Sahaya
Published: October 2023

Acne vulgaris is an inflammatory disorder of the skin that occurs when hair follicles get clogged with sebum and dead skin cells resulting in pustules, papules, or nodules. This condi-tion affects a large number of people throughout the world. Over time, various conventional ther-apies like topical, systemic and hormonal treatments have been prescribed by doctors to patients for managing acne. Amongst these, topical therapy is the first-line therapy dominated by retinoid and antibiotic drugs. However, conventional topical treatments have many drawbacks concerning physicochemical instability, poor ability to penetrate the skin, and wide-ranging side effects. Novel drug delivery systems are the formulations that were first devised to overcome the issues faced by traditional methods. Researchers have developed novel therapies for topical use, such as niosomes, transfersomes, solid lipid nanoparticles, microsponges, microemulsion, microspheres, nanocochleates, and liposomes, which can be used to target acne. These nanoparticulate systems aim to overcome the disadvantages of conventional treatment and provide higher safety and effi-cacy, along with an increase in the stability of the formulation. Many comparative studies have been conducted between the novel and conventional methods, which give us a better understand-ing of the safety and efficacy of drugs present in the formulation and prove that novel drug deliv-ery systems are more favorable than their conventional counterparts. This review article provides a brief insight into the conventional methods, discusses in depth the earlier mentioned novel ther-apies that can be used successfully in treating acne, and provides patent information on the drug delivery systems.
Effect of Virechana and Raktamokshan in Vicharchika: A Single Case Study
Authors: Sandeep S. Khandalikar  , Harshali R. Murade  , Priyanka G. Kengale
Published: October 2023

Skin protects us from various external invasions. Skin is largest organ and is exposed to disease and injury. Kushtha in Ayurveda represent all skin diseases. It is one among the Ashtaumahagad. There are two main types of Kushtha i.e., Mahakushtha and Kshudra Kushtha. Vicharchika (Kshudra Kushtha) is characterized by symptoms like Pidika, Kandu, Raktavarna or Shyavata, Vedana, Strava or Rukshta etc. All Kushtha are Tridoshaj the Pradhan Dosha involved in Vicharchika is Pitta. Virechana and Raktamokshana is indicated in treatment of Pittaja and Raktaja Vyadhi. A case study of patient of Vicharchika treated by Virechana and Raktmokshan along with Shamana Chikitsa is presented.
An insight into Purva Mimamsa Darshana and its conceptual comparison to Ayurveda
Authors: Priyanka  , Sri Nagesh K.A
Published: October 2023

Darshana addresses the philosophical elements by which they direct one to the reality and various other principles of life. Purva Mimamsa Darshana one among the Shad Darshana (Six philosophies), emphasise on the basic principles of Veda and the achievement of the ultimate goal through their practice. Understanding their principles and concepts paves way to clarify and enhance the knowledge regarding various concepts from Ayurveda. Purva Mimamsa propagates Dharma (laws/duty) and emphasise Karma (deeds), hence also called as Karma Mimamsa. This Darshana explains various concepts such as Pramanas (means of acquiring knowledge), Karma and its types, Atma (soul), Moksha (salvation) etc. where, few of these ideas diverge somewhat from those in Ayurveda, while others add clarity. Here, this article deals with Purvamimamsa Darshana which emphasises more on the basic principles of the Vedas and their matters in its support. Hence, through this article an attempt has been made to review and understand the concepts of Purva Mimamsa and its comparison to concepts in Ayurveda.
A literature review of Lohitaksha Marma with special reference to anatomical structure
Authors: Pooja Vitthal Chandurkar  , G.B. Sharma
Published: October 2023

According to Sushruta, Marma are constituted by confluence of Mansa, Sira, Snayu, Aasthi and Sandhi. They are the Sthana of Prana. According to Acharya Sushruta, Marma comprises of Jala, Vayu, Tej, Satva, Raja, Tama and Bhootatma, so that injury of Marma may lead to death. The concept of Marma is important in the clinical and surgical point of view. The science of Marma is called as half part of whole surgery. In this article an attempt is made to study the Lohitaksha Marma and its Viddha Lakshana (Traumatic effect) by considering the related literature.
A broad review on Shwasakuthar Rasa (herbo-mineral formulation)
Authors: Meenu Mishra  , Salil Jain
Published: October 2023

In Ayurveda Shwasakuthar Rasa is one of the important and widely used Rasaushadhis (herbo-mineral drug) in respiratory disorders especially in Shwasa (bronchial asthma) and Kasa (bronchitis) Roga. The Shwasakuthar Rasa contains minerals i.e., Parada (mercury), Gandhaka (sulphur), Tankana (borax) and Manahshila (arsenic sulphide) in purified form and herbs like purified Vatsanabha (aconitum ferox), Pippali (Piper longum), Maricha (Piper nigrum) and Shunthi (Zingiber officinale) as per Ayurvedic text. This review article documents the method of preparation, indications, probable mode of action and therapeutic properties of Shwasakuthar Rasa. This study concluded the antibacterial, anti-inflammatory, bronchodilator and expectorant effects of Shwasakuthar Rasa. So, it can be used as an effective medicine for respiratory disorders.
Vrikshayurveda - A Capital for Conservative Agronomy
Authors: Krishna Kishore Kumar  , Brijesh K.
Published: October 2023

Nature conservation has changed from an idealistic philosophy to a serious technology understanding of the nature of plant conservation is very much need of the hour that has elaborately mentioned in the literatures of Ayurveda. The interrelationships between conservation and sustainable use are considered, as well as the impact of the development of the discipline of conservation biology should be understood by the common man to save the Plant Kingdom. Traditional knowledge is vital for sustainability of natural resources including medicinal plants. Biodiversity conservation can be learnt from the context - specific local knowledge and intergenerational transmission of knowledge, skills and strategies, concern for well-being of future generations. The ancient text of Vrikshayurveda consists of about 170 different plant species including herbs, shrubs and trees. The text deals with Agri horticulture, home gardening, intercropping and storage etc. This paper intends to understand the traditional knowledge on biodiversity, practices and principles of Varahamihira’s, Brhat Samhita - Vrikshayurveda the text of 9th century AD in Growth, Conservation, Pest control and in-turn to check the diseases in Medicinal plants.
Ayurvedic perspective of Polycystic Ovarian Syndrome
Authors: Divya Rajpurohit  , A. Neelima
Published: October 2023

Women health remains a staggering challenge, particularly in the developing world. Around 5-15% of women in the reproductive age group suffer from hormonal imbalances that lead to menstrual irregularities.[1] A wide range of factors affect menstruation among all factors polycystic ovarian syndrome (PCOS) is the foremost factor. At least 70% of women with PCOS remain undiagnosed in primary care due to lack of knowledge and not giving attention to commonly occur menstrual irregularities. Incidence rate of PCOS is increasing day by day due to sedentary lifestyle and faulty daily routine, high consumption of unhealthy foods.
Concept of Vyadhikshamatvam
Authors: Ankita Sajwan  , Akanksha Joshi  , Basant Kumar Thakur
Published: October 2023

The natural ability of the body to fight diseases or prevent diseases is called Vyadhikshamatva (immunity). The body has an inherent capability to defend itself from the ailments, which termed as ‘Prakritirakshini’. This protects the body from the ill effects of unwholesome food, regimes and other non-conductive factors. The intervention by the physician is required only when the ‘Prakritirakshini’ or inherent power to protect the body fails. The innate ability to resist diseases is explained as Vyadhikshamatva by Charaka. Without the depletion of the natural strength of the body the disease doesn’t occur thus, strengthening the immune system is a natural way to help the body fight against the disease causing pathogens. The present article is aimed to review the concept of Vyadhikshamatva and various factors that help in occurrence and prevention of disease.
Peri-menopausal symptoms and its management by Yoga Therapy
Authors: Pratima G. Suryawanshi  , Brijesh R. Mishra  , Harish J. Purohit
Published: October 2023

With increased life expectancy today, women spend one-third of their life after menopause. Thus, more attention is needed towards peri-menopausal symptoms estrogen replacement therapy is the most effective treatment, however it has its own limitations. The present need is to explore new options for the management of perimenopausal symptoms. Yogic life style is a way of living which aims to improve the body, day and mind to Pranayama and Dhyana. Yoga been utilized as a therapeutic tools to achieve positive tools to achieve positive health and control and cure disease. The exact same as to how Yoga helps in various disease states is not known. There could be neurohormonal pathways with selective effect in each pathological situation. There have been multiple studies that have combined the many aspects of Yoga into a general Yoga session in order to investigate its effect on perimenopausal symptoms. Integrated approach of Yoga therapy can improve hot flushes and night sweats. There is increasing evidence suggesting that even the short-term practice of Yoga can decrease both psychological and physiological risk factors for cardiovascular disease studies conclude that our age old therapy, Yoga is fairly effective in managing perimenopausal symptoms.
Ayurvedic management of Avascular Necrosis of Femoral Head - A Case Study
Authors: Harshada S. Ashtankar  , Vidya Wasnik (Thatere)  , Sumeeta S. Jain
Published: October 2023

Osteonecrosis is a degenerative bone condition characterized by the death of cellular components of the bone secondary to an interruption of the subchondral blood supply. Also known as avascular necrosis. Avascular necrosis can be correlated to Asthi Majja Gata Vata and / or Asthi Dhatu Kshaya manifesting symptoms like Bhedo Asthi Parvanam (breaking type of pain in bones and joints), Sandhi Shula (joint pain), Mamsakshaya (muscular wasting), Balakshaya (weakness), Aswapna Santataruk (disturbed sleep due to continuous pain) and Sandhi Shaithilyam (afflicted joints) with Shiryanti Iva Cha Asthini Durbalani (destruction of bony tissue causing generalized weakness), Pratata Vata Rogini (other aggravated features of Vata). A wide range of treatment modalities have been mentioned in Ayurveda that are effective in such manifestations. A case of AVN with bilateral femoral head was treated with Shodhan followed by Brimhan. For Shodhan Jaladhauti, Bashpa Swedan, Vaitaran Basti and Manjhishthadi Niruha Basti was planned and Shashtishali Pinda Sweda and Panchatikta Kshir Basti were given along with internal medication. Patient was observed for symptomatic improvements based on the assessment done by the Harris Hip Score and the range of movement of the hip joint before and after treatment. The therapy provided marked relief in pain with improvement in gait and improved quality of life. Ayurvedic management provides significant relief and improves the quality of life.
Case study on Gridhrasi with Mahanimba Mula Twak Ghana Vati
Authors: Bibi Rukshana , Gupta Poonam
Published: October 2023

Background: Low back pain is one of the most common complaints in India that affects with 70% to 80% of the population. Among the various causes of low back pain, the intervertebral disc prolapsed is the most common and the pain may be confined in the lower back only or referred to as a leg, buttock or hip which often outline the features of Sciatica syndrome. In Ayurvedic Science, the disease Sciatica can be compared with Gridhrasi which is one of the most common disorders of Vata.  Aims & Objectives: This study aimed to access the efficacy of Ayurvedic management including Shodhana and Shamana Chikitsa in Gridhrasi. Materials and Methods: It is a single case study. A 45-year married man who has already been diagnosed with a bulge with superimposed right paracentral protrusion of L4-L5, correlated with Ghridrasi of the right leg from 5 months approached to our Ayurvedic hospital. He was treated with Panchakarma treatment including Yoga Basti, Kati Basti along with Shamana Chikitsa for one month. Results: Symptomatic assessment of patient was carried out after one month and satisfactory outcome was there and overall quality of life of patient was significantly improved. Conclusion: The after mentioned therapy gives symptomatic relief for the management of Gridhrasi.
A conceptual study of Yukti as Pramana or Guna and its utility in Ayurveda : A Review
Authors: Komalben Chavda  , Hardik P. Jyani  , Anita Kumari
Published: October 2023

Ayurveda, the traditional Indian medical system is considered as world's ancient medical system. It is holistic approach to health which is designed to help people live a longer, healthy and well-balanced life. The principles of Ayurveda are important for both the healthy and diseased conditions. Only Pariksha is able to give accessibility to this information. Charaka has therefore given the examination the greatest possible significance and it suggests that it be performed. Being a branch of medicine, Ayurveda focuses a higher value on the examination or Pariksha. Yukti has been included in the four-part investigation into Sat and Asat (manifested and unmanifested things) by Acharya Charaka, which is a unique contribution of Charaka. Yukti can be defined as both a Pariksha as well as Guna in Ayurveda.
Epifanische dialogen. De epifanische dimensie in literatuur, het missionaire gesprek en prediking
Authors: Van Ekris C.M.A.
Published: October 2023

Salvific experiences with God among contemporaries are an important source for theology, missiology, preaching and the assessment of spiritual life in our culture. My Bright Abyss of Christian Wiman is an interesting example of such a source. In this article the book is assessed as a biographical and poetic description of epiphanic moments. Inspired by Wiman, I explore the concepts of epiphany and dialogue in the context of mission and preaching. To be able to discern epiphanic fragments in the interior life of contemporaries we do not only need mystagogic qualities and dialogical competences in missionary encounters, but also practical theological methodologies. In the previous article, M.J. Kater mentioned four salvific fragments in My Bright Abyss (the fragmentary, human life, despair and atonement). My article is a homiletical-communicative elaboration of these four themes.
A Review of Personality Characteristics of Millennials
Authors: Dixit Anjali
Published: October 2023

Researchers have attempted to untangle the complexity of the Millennial generation through an approach based on four primary influences—time lag, cohabitation, duration, and personal and social characteristics. Research has also found cogitable personality differences between Millennials and the previous generation of Baby Boomers and Generation Xs. The Millennial generation, born 1982-2000, has attracted considerable attention in the media, educational institutions, and the workplace. Millennials are considered to be a demographic group that is highly educated and believed to have high levels of self-confidence and self-reliance. While being socially active, independent, and individualistic, they believe more in working in teams. They are the children of parents who provide a good nurturing and protective environment. The purpose of this paper is to conduct a comprehensive review of the available literature on the personality characteristics of Millennials, in order to get a better understanding the of Millennials Generation, we have detailed the old as well as emergent research on the Millennial Generation Personality, so that it may be leveraged in further research
Comparative Study on Private Teachers' Social, Financial, and Mental Problems during & Post Pandemic Scenario
Authors: Lahiri Gargi , Nath Soumen
Published: October 2023

The outbreak of the Covid 19 pandemic in India in March 2020, and the subsequent lockdown and closure of schools, colleges, and universities across the country, dealt a devastating blow to the country's educational system. In the aforementioned pandemic situation, private teachers faced a severe financial crisis due to a number of factors including parents' unwillingness to send their children to tuitions as well as allowing tutors to teach at home for fear of contracting the virus, education boards' reduction of syllabus, automatic promotion of students, and parents' financial constraints. The severe financial challenges that private instructors encountered as a result of the pandemic have received less attention. Due to the decrease in the number of students, private teachers had to work hard to make a living and found it difficult to meet both ends. Many private tutors were compelled to change careers and turn to other fields in order to make a living. The purpose of this article is to investigate the difficulties of survival and financial constraints experienced by private teachers in North Kolkata and the surrounding areas. Purposive sampling was used at the outset, when teachers from the known perimeter were approached, and they then assisted in the recruitment of others in the profession via rolling snowball sampling. Google form was used to create and administer a structured questionnaire. The research revealed some of the realities that teachers face. A large number of private teachers have had severe social, mental, and financial difficulties. Same Google form is used two times to collect primary data from same number of respondent to compare between during and post pandemic time conditions of private tutors
Aiding and Abetting in Suicide Among Children and Adolescents
Authors: Majchrzak Katarzyna
Published: October 2023

An increasing number of children and young people are committing suicide. Very often this occurs as a result of persuasion or with the provision of aid by peers. The purpose of this article is to introduce and explain the most important issues related to the offence under Article 151 of the Criminal Code. The perpetrator of the criminal act in question leads another person to take his or her own life. At the same time, it is not necessary for death to occur. The mere taking of actions directly aimed at suicide is sufficient.

Persuasion involves inducing another person to take his or her own life. The persuasion should be explicit in oral or written form. Providing assistance, on the other hand, may consist of providing a measure, giving advice or guidance.
Safeguarding the Environment in the Light of the Covenant
Authors: Opatrný Dominik
Published: October 2023

When the Biblical foundations of Christian environmental ethics are discussed, emphasis is usually placed on the theology of creation. However, the Compendium of the Social Doctrine of the Church starts with confidence based on the experience of Exodus, and states that “this reflection permits us to look to the future with hope, sustained by the promise and the covenant that God continually renews”. I argue that the theology of the covenant (not only with Noah) could and should supplement the traditional biblical themes used in the environmental discussion. The motif of the covenant not only links together various biblical texts relevant to environmental ethics, e.g. the story of Noah, Moses’ laws protecting animals, rules for the Sabbath, and prophetic visions of renewal, but also provides practical inspiration for environmentally responsible behavior.
Cross-Species Hybrids and Bioethics in Early Soviet Fiction
Authors: Mondry Henrietta
Published: October 2023

My article addresses issues of bioethics in cross-species hybridism raised in Robert and Beylis’ well-known “Crossing species boundaries” (2003) and the ensuing discussion by examination of two important stories written in the Soviet 1920s, “A Dog’s Heart” and “The Amphibian Man”. I argue that these two fictional narratives show that literature not only responds to changing trends in biological sciences but also heuristically considers and intuits wider social implications of radical experimentation. My approach is both synchronic and diachronic as I demonstrate that while being grounded in the same reformative atmosphere of the 1920s, the two texts present divergent responses to the issue of cross-species hybridism relevant for our contemporary debates. In particular, I deal with the notions of man playing God, species identity in analogy to ‘race’, procreation of human-animal hybrids, and also consider the relevance of culture-specific concepts of charismatic and distant species for cross-species discourse.
Acceptability of a Self-Led Mindfulness-Based Intervention for Teens with Type 1 Diabetes: Pilot Randomized Controlled Trial
Authors: Humiston Tori , Cummings Caroline , Suss Stephen , Cohen Laura B , Hazlett-Stevens Holly , Hughes Lansing Amy
Published: October 2023

Background

Diabetes distress among adolescents with type 1 diabetes has been associated with suboptimal diabetes outcomes, including lower quality of life, increased diabetes self-management challenges, and suboptimal glycemic outcomes.

Objective

This study examined the feasibility and acceptability of a scalable self-led mindfulness-based intervention to reduce diabetes distress in adolescents with type 1 diabetes.

Methods

Adolescents (N=25) aged between 14 and 18 years diagnosed with type 1 diabetes completed a baseline assessment. Participants were randomized to receive a 10-week self-guided mindfulness-based stress reduction workbook program (e-book or paper option) immediately (n=15) or after a 10-week wait (n=10). During the intervention period, participants completed weekly assignments and feedback surveys. At 10 weeks and 20 weeks, follow-up assessments were completed.

Results

Findings indicated that participants did not find the original intervention feasible or acceptable. Adolescents reported barriers to completing the weekly material, such as that they forgot or that the material was not sufficiently related to their diabetes management. Adolescents also reported that a digital format rather than a workbook or e-book may be more acceptable. Results from weekly surveys provided the foundation for recommendations for future iterations of the mindfulness-based intervention for adolescents with type 1 diabetes.

Conclusions

Participant feedback informed recommendations for self-led mindfulness programs for youth with type 1 diabetes. Adolescents indicated that a shorter, digital mindfulness-based intervention focused on diabetes-specific behaviors may be more helpful.

Trial Registration

ClinicalTrials.gov NCT05115175; https://clinicaltrials.gov/study/NCT05115175
Factors Associated With Work Engagement of Nurses During the Fifth Wave of the COVID-19 Pandemic in Japan: Web-Based Cross-Sectional Study
Authors: Muroi Kei , Ishitsuka Mami , Hachisuka Tomoko , Shibata Itsuka , Ikeda Tomohiko , Hori Daisuke , Doki Shotaro , Takahashi Tsukasa , Sasahara Shin-ichiro , Matsuzaki Ichiyo
Published: October 2023

Background

The COVID-19 pandemic has brought to light the prevalence of mental health issues among nurses. Work engagement (WE) is a concept that describes work-related positive psychological states and is of importance within mental health measures. There is, however, a lack of research on factors associated with the WE of nurses during the COVID-19 pandemic.

Objective

We aimed to determine which factors are associated with WE among nurses during the COVID-19 pandemic using the job demands-resources (JD-R) model as a framework.

Methods

A web-based cross-sectional survey was conducted among nurses working in acute care and psychiatric institutions in the prefectures of Chiba and Tokyo in Japan. The survey period occurred between August 8 and September 30, 2021, during a time when the number of patients with a positive COVID-19 infection increased. The 3-item version of the Utrecht Work Engagement Scale (UWES-3) was used to measure WE. Factors such as age, gender, years of experience, affiliated ward, COVID-19–related stress, financial rewards from the government and hospital, encouragement from the government and patients, and workplace social capital were assessed. A total of 187 participants were included in the final analysis. Multiple regression analysis was performed to examine the factors related to WE. Partial regression coefficients (B), 95% CI, and P values were calculated.

Results

The mean overall score for the UWES-3 was 3.19 (SD 1.21). Factors negatively associated with UWES-3 were COVID-19–related stress on work motivation and escape behavior (Β –0.16, 95% CI –0.24 to –0.090; P<.001), and factors positively associated with UWES-3 were affiliation of intensive care units (Β 0.76, 95% CI 0.020-1.50; P=.045) and financial rewards from the government and hospital (Β 0.40, 95% CI 0.040-0.76; P=.03).

Conclusions

This study examined factors related to WE among nurses during the COVID-19 pandemic using the JD-R model. When compared with findings from previous studies, our results suggest that nurses’ WE was lower than before the COVID-19 pandemic. Negative motivation and escape behaviors related to COVID-19 were negatively associated with WE, while there were positive associations with financial rewards from the government and hospital and affiliation with an intensive care unit. Further research into larger populations is needed to confirm these findings.
Coadaptation Between Smart Technologies and Older Adults Over Time: Protocol for a Scoping Review
Authors: Kokorelias Kristina Marie , Grigorovich Alisa , Harris Maurita T , Rehman Umair , Ritchie Louise , Levy AnneMarie , Denecke Kerstin , McMurray Josephine
Published: October 2023

Background

The Internet of Things (IoT) has gained significant attention due to advancements in technology and has potential applications in meeting the needs of an aging population. Smart technologies, a subset of IoT, can support older adults in aging in place, promoting independent living and improving their quality of life. However, there is a lack of research on how older adults and smart technologies coadapt over time to maximize their benefits and sustain adoption.

Objective

We will aim to comprehensively review and analyze the existing scientific literature pertaining to the coadaptation between smart technologies and older adults. The primary focus will be to investigate the extent and nature of this coadaptation process and explore how older adults and technology coevolve over time to enhance older adults' experience with technology.

Methods

This scoping review will follow the methodology outlined in the Joanna Briggs Institute Reviewer's Manual and adhere to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews) guidelines for reporting. Peer-reviewed articles will be searched in databases like Ovid MEDLINE, OVID Embase, PEDro, OVID PsycINFO, EBSCO CINAHL, the Cochrane Library, Scopus, IEEE Xplore, Web of Science, and Global Index Medicus. The research team will create a data extraction form covering study characteristics, participant characteristics, underlying models and frameworks, research findings, implications for technology coadaptation, and any identified study limitations. A directed content analysis approach will be used, incorporating the Selection, Optimization, and Compensation framework and Sex- and Gender-Based Analysis Plus theoretical framework.

Results

The results of this study are expected in January 2024.

Conclusions

This scoping review endeavors to present a thorough overview of the available evidence concerning how smart technologies interact with older adults over an extended period. The insights gained from this review will lay the groundwork for a research program that explores how older adults adapt to and use smart technologies throughout their lives, ultimately leading to improved user satisfaction and experience and facilitating aging in place with tailored support and user-centered design principles.

International Registered Report Identifier (IRRID)

PRR1-10.2196/51129
“Where do these warrish hands and heart of Venus come from?” Statius’ subversion of Ovidian militia amoris in the Thebaid
Authors: Ludwig Matt
Published: October 2023

Statius’ Thebaid has long been recognized as a highly allusive epic, but one system of its allusions— that which engages with Latin love elegy—has received less study than others. To address this oversight, I argue in this article that Statius makes marked references to techniques and tropes of Ovidian elegy in his use of love language throughout the Thebaid. After cataloguing a range of the epic’s Ovidian elegiac intertexts, I argue that Statius sustains an allusion to Amores book one in Thebaid book five. In Thebaid book five, Hypsipyle provides an inset narrative of Venus’ intervention in Lemnos: under the influence of the spurned love goddess, the Lemnian women slaughter the entire male population. In my reading, Hypsipyle’s narrative represents a characteristically Statian subversion of his literary models. In book one of the Amores, Ovid develops the ‘warfare of love’ (militia amoris) trope as a tongue-in-cheek revision of both previous epicists’ and elegists’ more morose and austere poetics. Statius, conversely, recasts the light and humorous elements of Ovid’s militia amoris into his own aesthetic mould, whereby love becomes as horrifying and destructive a force as war in the cosmos of the Thebaid. That is, Statius mirrors Ovid’s own techniques of subversive allusion to mark his poetics also as both indebted to and an innovating of elegiac precursors. But in Statius’ case, the world of elegaic amor becomes graver rather than lighter, more severe than humorous. In sum, Statius’ subversive allusions to Ovidian elegy in his Thebaid, particularly in book five, transform Ovid’s levis love (Am. 3.1.41) into its most monstrous counterpart.
Fire Risk Assessment and Emergency Route Decision Analysis Based on Big Data Platform—Example of Huizhou
Authors: Liu Haolong , Li Jingpeng , Wang Yun-Shang , Wang Ruei-Yuan
Published: October 2023

With the process of urbanization, the frequency of fires is gradually increasing, and fire emergency work has become particularly important. This paper takes Huizhou City as an example and conducts a fire risk assessment based on the various conditions of the city using the Gaode big data platform. The analysis shows that the low-risk area within the Fourth Ring Road in Huicheng District is about 91.8%, the medium-risk area is about 6.72%, the secondary high-risk area is about 1.16%, and the high-risk area is about 0.31%. Meanwhile, we use Python code to calculate the decision analysis plan for fire emergency route selection. By collecting data on fire site locations, fire stations, and hospitals, combined with dynamic information such as road conditions and traffic flow, and utilizing the functions of the Gaode big data platform, route calculation and optimal path selection are carried out. This method will improve the efficiency of fire emergency response, reduce rescue time, and provide better assistance to the affected population.
The Therapeutic Wound Healing activities of Various Medicinal Plants
Authors: Wadkar Hemalata Sagar , Pinjari Rukhsana Mahiboob
Published: October 2023

The skin protects the internal organs from mechanical, chemical, and thermal injury and is thus the body's first line of defence. It has an advanced immune response that protects the body from harmful microbes. Healing a wound is a dynamic process supported by a plethora of cellular processes such as homoeostasis, inflammation, proliferation, and remodelling, all of which must work in tandem to restore the health of the injured tissue. Following cutaneous injury, germs may rapidly invade subcutaneous tissues, leading to painful chronic sores and even death. Wound therapy and infection prevention have both benefited greatly from the use of natural phytomedicines, which have been used extensively due to their potent pharmacological effects. Phytotherapy has been used effectively to heal cutaneous wounds, delay the emergence of infections, and limit the use of antibiotics that contribute to dangerously widespread antibiotic resistance since ancient times. Achiella millefolium, Aloe vera, Althaea officinalis, Calendula officinalis, Matricaria chamomilla, Curcuma longa, Eucalyptus, Jojoba, plantain, pine, green tea, pomegranate, and Inula are only a few of the many commonly used botanicals in the Northern Hemisphere for wound healing. This article discusses the most popular medicinal plants of the Northern Hemisphere used for wound healing, and it also offers suggestions for effective natural alternatives.
El Boletín Titikaka y Ia vanguardia andina
Authors: Pulido Herráez María Begoña
Published: October 2023

El Boletín Titikaka y la vanguardia andina propone un acercamiento a la hoja cultural publicada entre 1926 y 1930 en la ciudad andina de Perú. El propósito de identificar el proyecto estético-ideológico de la publicación puneña como promotora de una vanguardia andina. El análisis del boletín se centra en el modo como participan en dos polémicas de la segunda mitad de los años veinte, la que se refiere al indigenismo (en sus variantes social y literaria) y la que se remite al nuevo arte de vanguardia. Adentrarse en el Boletín Titikaka es comprender como un grupo pequeño de intelectuales supieron apropiarse, desde una ciudad aislada del Perú andino, de los movimientos artísticos y sociales que se extendían por Perú, Latinoamérica y Europa, pero también refractaron y ofrecieron a otras regiones de Perú y Latinoamérica, una perspectiva "andina" sobre los debates del indigenismo, el andinismo, el latinoamericanismo y la vanguardia.
Medio de Control Constitucional Previo para Reformas Constitucionales en México: Una Propuesta
Authors: Granados Samaniego Tonatiuh
Published: October 2023

En México, ningún texto de reforma constitucional técnicamente puede ser considerado inconstitucional, sin embargo, algunos textos si pueden llegar a ser inconvencionales. El Sistema Jurídico Mexicano no contempla ningún medio de control constitucional, ni previo ni a posteriori para recurrir esas reformas constitucionales inconvencionales, por lo que resulta necesario la instrumentación de un medio de control constitucional previo para este tipo de reformas.