bluuebunny/crossref_metadata_2025 huggingface dataset:
Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation
Authors: Vedadghavami Armin , Hakim Bill , He Tengfei , Bajpayee Ambika G.
Published: July 2022

Background

Insulin-like growth factor-1 (IGF-1) has the potential to be used for osteoarthritis (OA) treatment but has not been evaluated in clinics yet owing to toxicity concerns. It suffers from short intra-joint residence time and a lack of cartilage targeting following its intra-articular administration. Here, we synthesize an electrically charged cationic formulation of IGF-1 by using a short-length arginine-rich, hydrophilic cationic peptide carrier (CPC) with a net charge of +14, designed for rapid and high uptake and retention in both healthy and arthritic cartilage.

Methods

IGF-1 was conjugated to CPC by using a site-specific sulfhydryl reaction via a bifunctional linker. Intra-cartilage depth of penetration and retention of CPC-IGF-1 was compared with the unmodified IGF-1. The therapeutic effectiveness of a single dose of CPC-IGF-1 was compared with free IGF-1 in an IL-1α-challenged cartilage explant culture post-traumatic OA model.

Results

CPC-IGF-1 rapidly penetrated through the full thickness of cartilage creating a drug depot owing to electrostatic interactions with negatively charged aggrecan-glycosaminoglycans (GAGs). CPC-IGF-1 remained bound within the tissue while unmodified IGF-1 cleared out. Treatment with a single dose of CPC-IGF-1 effectively suppressed IL-1α-induced GAG loss and nitrite release and rescued cell metabolism and viability throughout the 16-day culture period, while free IGF at the equivalent dose was not effective.

Conclusions

CPC-mediated depot delivery of IGF-1 protected cartilage by suppressing cytokine-induced catabolism with only a single dose. CPC is a versatile cationic motif that can be used for intra-cartilage delivery of other similar-sized drugs.
Enhanced metabolic flux of methylerythritol phosphate (MEP) pathway by overexpression of Ginkgo biloba 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Reductase 1 (GbHDR1) gene in poplar
Authors: Kang Min-Kyoung , Kim Ji-Young , Choi Young-Im , Hu Lujie , Yang Chaodong , Jin Zhehao , Park Yun Ji , Kim Soo-Un , Kim Sang-Min
Published: July 2022

Terpenoids are of great interests in a broad range of health-beneficial biological activities and various industrial applications. In plants, terpenoids are synthesized by two distinct pathways, methylerythritol phosphate (MEP) and mevalonate pathways in a separate location. MEP pathway supplies isoprene precursors isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP) of terpenoid biosynthesis in plant plastids. The MEP pathway has been an engineering target to increase the metabolic flux towards higher terpenoid production in plants. 1-Hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) is the terminal step of the MEP pathway to regulate the terpenoid biosynthesis and is encoded by three paralogous genes in Ginkgo biloba. In this study, we assessed the effect of overexpression of GbHDR1 on terpenoid metabolism in poplar plants. Overexpression of GbHDR1 in poplar plants accelerated growth and delayed winter-bud formation. Transcript levels of gibberellin, chlorophylls, and carotenoid biosynthetic genes in GbHDR1-overexpressing (GbHDR1ox) poplars were up-regulated, suggesting metabolic flux enhancement. Moreover, enhanced contents of chlorophylls and carotenoids in the leaves of the GbHDR1ox plants resulted in a higher photosynthetic rate as a consequence. Therefore, we expect the GbHDR1 overexpression will be a desirable engineering point of the MEP pathway for enhancing terpenoid metabolic flux and production in plants.
Your heart is where your roots are? Place attachment and belonging among Polish and Lithuanian returnees
Authors: Trąbka Agnieszka , Klimavičiūtė Luka , Czeranowska Olga , Jonavičienė Dovile , Grabowska Izabela , Wermińska-Wiśnicka Iga
Published: July 2022

The reintegration of return migrants has been an important issue in migration studies for several decades. While much research has been done to identify returnees’ strategies and their labour market situation in their country of origin, little attention has been devoted to their attachment, especially in quantitative studies. This paper seeks to address this gap, analysing predictors of place attachment and belonging among Polish and Lithuanian returnees from the United Kingdom. We consider autobiographical factors connected to migration history and time spent in a place; relational factors linked to social networks, bonds and contacts; cultural factors connected to feeling “at home”; and economic and welfare factors primarily linked to economic stability and job opportunities. Our analysis is based on a web survey of Polish and Lithuanian returnees conducted in 2020 (n = 740). The results reveal that the influence of autobiographical, cultural and relational determinants on returnees’ attachment is greater than the influence of their labour market position.
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden: a prospective study
Authors: Stjernbrandt Albin , Pettersson Hans , Lundström Ronnie , Liljelind Ingrid , Nilsson Tohr , Wahlström Jens
Published: July 2022

Background

Raynaud’s phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud’s phenomenon in the general population of northern Sweden. Secondary aims were to determine how individual and exposure factors affect the course of Raynaud’s phenomenon, and to assess gender differences.

Methods

A prospective, survey-based, closed-cohort study was conducted on a sample of men and women between 18–70 years of age, living in northern Sweden. Data on Raynaud’s phenomenon characteristics and general health status were collected during the winters of 2015 (baseline) and 2021 (follow-up). Rates of incidence, remission, and persistence were calculated. Binary logistic regression was used to determine the association between baseline variables and the course of Raynaud’s phenomenon. Results: The study population consisted of 2703 women (53.9%) and 2314 men. There were 390 women (14.5%) and 290 men (12.7%) reporting Raynaud’s phenomenon in the follow-up survey. The annual incidence proportion was 0.7% among women and 0.9% among men (gender difference p = 0.04). The annual remission proportion was 4.4% and 5.5%, respectively (p = 0.05). Having sustained a cold injury affecting the hands since baseline was significantly associated with incident Raynaud’s phenomenon (OR 3.92; 95% CI 2.60–5.90), after adjusting for age and gender.

Conclusions

In the general population of northern Sweden, Raynaud’s phenomenon is a common but variable condition, where symptoms may remit over time. Men had a higher incidence proportion than women. The results support a possible causal pathway where cold injury can precede the onset of Raynaud’s phenomenon.
Anesthesia and cancer recurrence: an overview
Authors: Brogi Etrusca , Forfori Francesco
Published: July 2022

Several perioperative factors are responsible for the dysregulation or suppression of the immune system with a possible impact on cancer cell growth and the development of new metastasis. These factors have the potential to directly suppress the immune system and activate hypothalamic-pituitary-adrenal axis and the sympathetic nervous system with a consequent further immunosuppressive effect.

Anesthetics and analgesics used during the perioperative period may modulate the innate and adaptive immune system, inflammatory system, and angiogenesis, with a possible impact on cancer recurrence and long-term outcome. Even if the current data are controversial and contrasting, it is crucial to increase awareness about this topic among healthcare professionals for a future better and conscious choice of anesthetic techniques.

In this article, we aimed to provide an overview regarding the relationship between anesthesia and cancer recurrence. We reviewed the effects of surgery, perioperative factors, and anesthetic agents on tumor cell survival and tumor recurrence.
Interdisciplinary Approach and Patient/Family Partners to Improve Serious Illness Conversations in Outpatient Oncology
Authors: Wasp Garrett T. , Cullinan Amelia M. , Anton Catherine P. , Williams Andy , Perry James J. , Holthoff Megan M. , Buus-Frank Madge E.
Published: July 2022

PURPOSE:

We aimed to increase Serious Illness Conversations (SIC) from a baseline of, at or near, zero to 25% of eligible patients by December 31, 2020.

METHODS:

We assembled an interdisciplinary team inclusive of a family partner and used the Model for Improvement as our quality improvement framework. The team developed a SMART Aim, key driver diagram, and SIC workflow. Standardized screening for SIC eligibility was implemented using the 2-year surprise question. Team members were trained in SIC communication skills by a trained facilitator and received ongoing coaching in quality improvement. We performed Plan-Do-Study-Act cycles and used audit-feedback data in weekly team meetings to inform iterative Plan-Do-Study-Act cycles. The primary outcome was the percent of eligible patients with documented SIC.

RESULTS:

Over 18 months, three clinics identified 63 eligible patients; of these, 32 (51%) were diagnosed with head and neck cancer and 31 (49%) with sarcoma. The SIC increased from a baseline near zero to 43 of 63 (70%) patients demonstrating three shifts in the median (95% CI). Conversations were interdisciplinary with 25 (57%) by oncology MD, six (14%) by advanced practice registered nurse, and 13 (30%) by specialty palliative care. We targeted four key drivers: (1) standardized work, (2) engaged interdisciplinary team, (3) engaged patients and families, and (4) system-level support.

CONCLUSION:

Our approach was successful in its documentation of end points and required resource investment (training and time) to embed into team workflows. Future work will evaluate scaling the approach across multiple clinics, the patient experience, and outcomes of care associated with oncology clinician–led SIC.
Face-sparing Congenital Generalized Lipodystrophy Type 1 Associated With Nonclassical Congenital Adrenal Hyperplasia
Authors: Costa Sara , Sampaio Lurdes , Berta Sousa Ana , Xing Chao , Agarwal Anil K , Garg Abhimanyu
Published: July 2022

Context

Congenital generalized lipodystrophy, type 1 (CGL1), due to biallelic pathogenic variants in AGPAT2, is characterized by the near total loss of body fat from the face, trunk, and extremities. Patients develop premature diabetes, hypertriglyceridemia, hepatic steatosis, and polycystic ovary syndrome. However, sparing of the facial fat and precocious pubertal development has not been previously reported in CGL1.

Case Description

We report a 21-year-old woman of European descent with CGL1 who had sparing of the facial fat and premature thelarche at birth with premature pubarche and menstrual bleeding at age 3 years. Her serum 17-OH progesterone level rose to 1000 ng/dL (30.26 nmol/L) after cosyntropin stimulation test, suggestive of nonclassical congenital adrenal hyperplasia (NCAH) due to 21-hydroxylase deficiency. Hydrocortisone replacement therapy from age 3.5 to 10 years resulted in cessation of menstruation and growth of pubic hair, and a reduction of breast size. Sanger and whole-exome sequencing revealed compound heterozygous variants c.493-1G>C; p.(Leu165_Gln196del), and c.del366_588+534; p.(Leu123Cysfs*55) in AGPAT2 plus c.806G>C; p.(Ser269Thr) and c.844G>T; p.(Val282Leu) in CYP21A2. She developed diabetes at age 13 requiring high-dose insulin and had 7 episodes of acute pancreatitis due to extreme hypertriglyceridemia in the next 5 years. Metreleptin therapy was initiated at age 18 and after 3 years, she had remission of diabetes and hypertriglyceridemia; however, menstrual irregularity and severe hirsutism did not improve.

Conclusion

Concomitant NCAH in this CGL1 patient was associated with precocious pubertal development and sparing of facial fat. Metreleptin therapy drastically improved her hyperglycemia and hyperlipidemia but not menstrual irregularity and hirsutism.
Poetry, Ghosts, Mediation
Authors: Chen Jack W.
Published: July 2022

This essay takes the example of a poem composed by a ghost in the Tang dynasty—one of many preserved in literary anthologies and treated as actually having been authored by the dead—as an entry point to ask broader questions of ghostly haunting and poetic presence. What the essay demonstrates is how both the ghost and the poem are informed by logics of analog mediation (rather than representation): how the ghost finds purchase in the world only through bodily possession, spatial haunting, material displacement, and psychic transference and how the poem effects the transmission of mind through the channels of linguistic form, meter, and rhyme. Neither the ghost nor the poem exists except in or as its mediations, yet through these mediations, both the ghost and the poem become present and are communicated into the world. While contemporary media theory has identified the intertwined discourses of technology and spiritualism, the focus has almost solely been on the nineteenth century and later, on the age of electric and electronic telecommunications. The medieval ghost poem, as an exemplary case, complicates this account, showing how poetry has long served as a necrotechnology that mediates the dead and returns ghosts to presence.
The Para-Worlds of Lesley Nneka Arimah’sWhat It Means When a Man Falls from the Sky
Authors: Kumavie Delali
Published: July 2022

This essay argues that Lesley Nneka Arimah’s collection of short stories, What It Means When a Man Falls from the Sky, evokes para-worlds that reveal and contend with the world and its norms. Examining the collection’s entwinement of magical, mythical, and animist modes with science, technology, and innovation, the essay shows how Arimah’s work creates its own metagenre, which functions as a paranormal frame that disrupts the common sense of existing interpretive frameworks of progress and difference. The paranormal in Arimah’s work is a space where the illegible significance of Blackness exists. These para-worlds, the essay contends, are paranormal because they function as parallel, ancillary, and barricading structures that reveal the spatial and temporal continuums that order the world. Viewing the norm as the world-constituting structures instantiated in 1492, the essay contends that Arimah’s para-world functions as a continuum to reveal the ever-present structures of violence.
Wood ants learn the magnetic direction of a route but express uncertainty because of competing directional cues
Authors: Collett Thomas S. , Philippides Andrew O.
Published: July 2022

Wood ants were trained indoors to follow a magnetically specified route that went from the centre of an arena to a drop of sucrose at the edge. The arena, placed in a white cylinder, was in the centre of a 3D coil system generating an inclined Earth-strength magnetic field in any horizontal direction. The specified direction was rotated between each trial. The ants’ knowledge of the route was tested in trials without food. Tests given early in the day, before any training, show that ants remember the magnetic route direction overnight. During the first 2 s of a test, ants mostly faced in the specified direction, but thereafter were often misdirected, with a tendency to face briefly in the opposite direction. Uncertainty about the correct path to take may stem in part from competing directional cues linked to the room. In addition to facing along the route, there is evidence that ants develop magnetically directed home and food vectors dependent upon path integration. A second experiment asked whether ants can use magnetic information contextually. In contrast to honeybees given a similar task, ants failed this test. Overall, we conclude that magnetic directional cues can be sufficient for route learning.
Free Energy and Solvation Structure Analysis for Adsorption of Aromatic Molecules at Pt(111)/Water Interface by 3D-RISM Theory
Authors: Takamatsu Akihiko , Higashi Masahiro , Sato Hirofumi
Published: July 2022

The free energy change of aromatic molecules adsorbed at a Pt(111)/water interface was analyzed using the three-dimensional reference interaction site model (3D-RISM) theory with density functional theory (DFT), compared with the reported experimental data. The changes in the solvation structure induced by molecular adsorption were discussed.
DSMZCellDive: Diving into high-throughput cell line data
Authors: Koblitz Julia , Dirks Wilhelm G. , Eberth Sonja , Nagel Stefan , Steenpass Laura , Pommerenke Claudia
Published: July 2022

Human and animal cell lines serve as model systems in a wide range of life sciences such as cancer and infection research or drug screening. Reproducible data are highly dependent on authenticated, contaminant-free cell lines, no better delivered than by the official and certified biorepositories. Offering a web portal to high-throughput information on these model systems will facilitate working with and comparing to these references by data otherwise dispersed at different sources.

We here provide DSMZCellDive to access a comprehensive data source on human and animal cell lines, freely available at celldive.dsmz.de. A wide variety of data sources are generated such as RNA-seq transcriptome data and STR (short tandem repeats) profiles. Several starting points ease entering the database via browsing, searching or visualising. This web tool is designed for further expansion on meta and high-throughput data to be generated in future. Explicated examples for the power of this novel tool include analysis of B-cell differentiation markers, homeo-oncogene expression, and measurement of genomic loss of heterozygosities by an enlarged STR panel of 17 loci.

Sharing the data on cell lines by the biorepository itself will be of benefit to the scientific community  since it (1) supports the selection of appropriate model cell lines, (2) ensures reliability, (3) avoids misleading data, (4) saves on additional experimentals, and (5) serves as reference for genomic and gene expression data.
Hrabina du Barry jako faworyta Ludwika XV (1768-1774)
Authors: Niedziela Rafał
Published: July 2022

COUNTESS DU BARRY AS A ROYAL FAVORITE OF LOUIS XV (1768-1774) Jeanne Bécu, countess du Barry, was the last favorite of King Louis XV of France. As a woman of the people, with no property, no name and an unclear past, she became the heroine of numerous satires and pamphlets. Contemporaries presented her as a debauched, vulgar, vain and spendthrift person. These accusations are repeated by many historians to this day. This article is an attempt to show the origins of these negative opinions and uncover the real picture of her life at the Versailles court between 1768-1774.
Estratégias para promover motivação para a atividade física no contexto da atenção primária à saúde
Authors: Sandri Anelise , Delevatti Rodrigo Sudatti , Matias Thiago Sousa
Published: July 2022

A promoção da saúde envolve aspectos afetivos e cognitivos para mudanças de comportamento, assim destaca-se a necessidade de maior atenção voltada aos aspectos motivacionais relacionados à adesão e manutenção das pessoas à prática de atividade física no contexto da Atenção Primária à Saúde (APS). Este ensaio tem como objetivo apresentar a etapa inicial de um modelo teórico-metodológico de intervenção para a atividade física no contexto da APS, que considerem os processos regulatórios da motivação. O macroprojeto foi organizado sob três processos: desenvolvimento (foco exclusivo deste ensaio); validação e avaliação/aplicação. A partir da análise bibliográfica foram extraídas 17 estratégias para promover motivação para a atividade física. Após, foi sugerido formas de implementar tais estratégias no contexto da atividade física da APS. Este trabalho visa democratizar e encorajar a apreciação dos aspectos afetivos e cognitivos por profissionais, pesquisadores e gestores interessados na promoção da prática de atividade física para a saúde no contexto da APS.
Impact of Motivation and Workload on Service Time Components: An Empirical Analysis of Call Center Operations
Authors: Ashkanani Ahmad M. , Dunford Benjamin B. , Mumford Kevin J.
Published: July 2022

We study the joint effects of motivation and workload on human servers’ service time. Using operational and survey data from a call center with a pooled queue structure and limited financial incentives, we examine how individual differences between servers’ trait intrinsic motivation (IM) and extrinsic motivation (EM) impact their average offline, online, and total service times in response to changing workloads. We find significant differences in the patterns of workload and service time relationships across different stages of the service request between servers possessing different combinations of trait motivation. For example, servers with a combination of high IM and low EM were approximately 15% (161%) faster in processing the offline portion of service requests than their peers with the opposite combination (low and high) when workload levels were low (high), respectively. In contrast, servers with high IM-low EM were approximately 35% (5%) slower in processing the online portion of service requests than their low IM-high EM counterparts when workload levels were low (high), respectively. Our findings suggest important nuances in how servers with different trait motivation types respond to changing workload across different stages of the service request. The behavioral pattern shown by high IM-low EM servers is consistent with the preferences of productivity-seeking call center managers who favor speedup and slowdown at certain stages of the service request, conditional to workload. These findings underscore the importance of accounting for trait-based individual differences for a more complete understanding of the complex relationship between workload and service time.

This paper was accepted by Charles Corbett, operations management.
World Experience in Organizing the Educational Process in the Discipline of «Physical Culture» in Higher Education Institutions During the Pandemic
Authors:   Oles Honchar Dnipro National University, Lopuha Hanna , Reshetilova Valeriya ,   Prydniprovska State Academy of Physical Culture and Sports, Mikhailenko Yuliya ,   Prydniprovska State Academy of Physical Culture and Sports
Published: July 2022

The article is devoted to the research of the problem of organization of the educational process in the discipline «Physical Culture» in higher education institutions during the pandemic period. The aim of the article is to analyze and summarize the world research literature on the problem of research. It was found out: first, teachers and students faced technical difficulties; lack of educational resources; insufficient information literacy of teachers; the difficulty of implementing regular curricula online; secondly, these are psychological problems: in practical classes, traditional teacher-student communication has been replaced by student-computer-teacher communication; limited conditions for students to study at home and doubts about online physical education. But, despite the difficulties, the practice of physical education classes was as follows. In China, a mixed method of teaching physical education has been proposed – learning using an online course + push notifications of a public WeChat account, ie (synchronous and asynchronous learning). In Northern Macedonia, teachers used various forms, such as live online classes, recorded videos, student assignments, projects, or links to go. Weekly «movement diaries» were practiced in Hungary. In Italy, teachers were invited to teach through distance learning. In the US, SHAPE America has provided virtual online resources on health and physical education, #HPEatHome, including videos with theoretical and practical content. Teachers conducted online classes and performed one hour of physical activity daily. Teachers in Turkey read online courses through an educational information network called EBA, prepared by the Ministry of Education. Conclusions. The period of self-isolation, in world practice, has identified several types of distance learning that teachers have used to ensure the educational process of «Physical Education». This is synchronous and asynchronous learning, or blended learning. This is synchronous and asynchronous learning, or blended learning. Physical education teachers have gained a wealth of experience gained during the pandemic and can use it when they return to normal activities.
Physical Activity as an Aspect of Students’ Social and Educational Life
Authors:   National University ", Korzh Nataliya ,   Zaporizhzhia Polytechnic", Shuba Liudmyla ,   National University "Zaporizhzhia Polytechnic", Shuba Victoria ,   Prydniprovska State Academy of Physical Culture and Sports
Published: July 2022

Education – education and upbringing – is the most noble and responsible sphere of human activity precisely because here a person is formed as a person, his/her world outlook and culture are intertwined, the foundations of future profession, career, life success are laid. The rapid development of the modern world, of course, influences the character of the mental work of the individual and requires constant improvement of mental abilities, skills and skills aimed at productive work of the human brain in order to create innovative ideas, projects. But at the same time, a decrease in physical activity has a negative impact on mental activity, attitudes towards personal and social life position, and reduces the quality of life, both social and personal. Material and methods. The purpose of the study – to analyze the impact of exercising on the social and educational activity of life of modern student youth. The study involved 337 students of different sexes from the National University of Zaporizhia Polytechnic who were divided into two groups: the first group Physically Passive Group – 153 students who never visited fitness centers and did not exercise independently for the purpose of additional physical education; second Physical Activity Group – 184 students who regularly exercise independently or regularly visit fitness centers and other sports sections. Conclusion: Based on the above, we draw attention to the fact that students in both the physically active and the physically passive groups have a strong desire for material support and good health. But at the same time, students belonging to Physically Passive Group have little motivation to make any effort to achieve their goals.
Modern Computer-Integrated Technologies of the Foreign-Language Training in Post-Secondary Technical Institutions
Authors:   National Transport University, Sura Nataliia
Published: July 2022

The article dwells upon the deductive opportunities and the analysis of the computer-integrated technologies in the context of professional training in the foreign language in post-secondary technical institutions. The article gives the methods of deductive realization of computer-integrated technologies of professional training in foreign language in post-secondary technical institutions which allowed us to identify and classify them by character, level of cooperation and complexity of application during the learning process. It dissects the main approaches to the organization of professional training in the foreign language during workshops via computer and Internet. It determines the notion of ‘remote learning’, outlines its benefits as for the organization of the learning process, the stages of pedagogical technologies of remote learning (‘professor-student’; ‘professor-students’; ‘learning via Internet’; ‘virtual-training methodology with the application of all forms of remote learning’). The author highlights the positive features .and advantages of considered computer-integrated technologies of the foreign-language training in post-secondary technical institutions. The items of integration into the global community via computer and Internet and pedagogical conditions that ensure the deductive effectiveness of application of modern computer-integrated technologies in the context of the foreign-language training in post-secondary technical institutions are considered in the abstract.
The Latest Technologies for Teaching Physical Education to Students in the Context of Global Change and Current Challenges
Authors:   State Institution Luhansk Taras Shevchenko National University, Otravenko Olena , Dovgan Nadiia ,   University of the State Fiscal Service of Ukraine, Gancheva Vladyslava ,   Institute of Education Content Modernization, Goncharenko Volodymyr ,   Sumy State University
Published: July 2022

The article notes that the modernization of physical education in general secondary education has undergone significant changes in the context of global change and challenges. The purpose of the study is to summarize scientific and methodological literature and advanced pedagogical evidence of the best teachers of physical education, to identify modern approaches to teaching physical education using the latest technologies and interactive teaching methods in distance learning aimed at creative personality development, innovation in practice of physical education teachers in the context of global change and current challenges. To meet the physical culture and sports needs and motives of young students it is necessary to comprehensively use the latest technologies and interactive teaching methods, modern recreational tools for various types of physical activity, aimed at health and active youth leisure, strengthening skills, strengthening health attitude to it, the development of personal physical education, conscious leading a healthy lifestyle, especially to ensure the quality of education during the pandemic. We offer active use of webinars, trainings, challenges with the use of case technologies, ICT tools, the latest technologies in distance learning. Distance learning in physical education with a good setup of the educational process is an effective way to maintain students’ health during forced quarantine connected with martial law, both physical and psychological, as it helps to some extent to relieve stress and distract from the burden and constant use of gadgets.
Physical Activity as a Component of a Healthy Lifestyle
Authors:   National University ", Rybalko Lina ,   Yuri Kondratyuk Poltava Polytechnic"
Published: July 2022

The article is devoted to the study of health and healthy lifestyles. The aim of the article is to reveal the essence of a healthy lifestyle, the conditions of its formation in students and scientific substantiation of the role of physical activity in the formation, strengthening and maintaining human health. A healthy lifestyle is seen as a form of daily life that includes appropriate principles and rules that develop the body's adaptive capacity, contribute to the successful formation, maintenance, strengthening or restoration of health and full activity. Optimal motor regime is interpreted as intensity-regulated physical activity that fully satisfies the biological need for movement, meets the functional capabilities of the body, takes into account the specifics of professional activities and promotes a healthy lifestyle, maintaining and promoting health. The main characteristics of human motor activity are his physical fitness and physical condition. Physical fitness is considered as a result achieved by training motor skills and increasing the level of efficiency of the body, which are necessary for the assimilation and performance of a certain type of activity. Whereas physical condition is an indicator of a person's condition and level of physical health. The latter depends on natural and social factors. Physical condition and physical fitness determine a person's physical development, which can be changed and improved through exercise, work and rest, nutrition. The results of the study of a healthy lifestyle of student youth (on the example of students of the Faculty of Physical Culture and Sports of the National University "Poltava Polytechnic named after Yuri Kondratyuk") showed that young people are ready to form HLS or are already concerned that lifestyle meets healthy criteria. Young people approach this through self-assessment of their own way of life and the way of life of their friends and acquaintances, gaining knowledge about health and a healthy lifestyle and its composition, doing sports.
Modern Tendencies of Preparation of Future Specialists in Physical Education and Sports for Activity in the Field of Fitness
Authors:   State Institution Luhansk Taras Shevchenko National University, Shynkarova Olena
Published: July 2022

The article is devoted to the research of the problem of preparation of future specialists in physical education and sports for activity in the field of fitness. Modern vocational education is characterized by a period of radical changes in approaches to training a competitive specialist, makes higher demands on the modernization of educational content and promotes the formation of professional competencies of graduates of higher education institutions aimed at education and self-education throughout life. The content of vocational education carries a set of knowledge, skills and abilities, the possession of which allows you to work in your chosen profession. In the modern period, scientists are focusing their efforts on finding innovative ways to reform the system of higher physical education and pay considerable attention to transforming the content and forms of training of future professionals in physical culture and sports, in particular in fitness. As the fitness system is constantly evolving, it needs professional staff to provide quality services. Heads of higher education institutions should take into account the current demand of the population for fitness services and promote the development of a system of training in higher education institutions of physical education.
Vascular access teams: a global outlook on challenges, benefits, opportunities, and future perspectives
Authors: Morrow Shonda , DeBoer Erica , Potter Christopher , Gala Smeet , Alsbrooks Kimberly
Published: July 2022

Background:

Specialized vascular access training for medical professionals organized into vascular access teams (VATs) was shown to improve patient outcomes, clinical efficiency, and cost savings. Professional perspectives on VAT benefits, organization, challenges, and opportunities on a global scale remain inadequately explored. Using detailed perspectives, in this study, we explored the global VAT landscape, including challenges faced, clinical and clinico-economic impacts of VATs, with emphasis on underresearched facets of VAT initiation, data dissemination, and metrics or benchmarks for VAT success.

Methods:

Semistructured in-depth interviews of 14 VAT professionals from 9 countries and 5 continents were used to elicit qualitative and quantitative information.

Results:

Catheter insertions (100%) and training (86%) were the most performed VAT functions. Based on a 1–7 scale evaluating observed impacts of VATs, patient satisfaction (6.5) and institutional costs (6.2) were ranked the highest. VAT co-initiatives, advanced technology utilization (6.6), and ongoing member training (6.3) distinctly impacted VAT endeavors. Most institutions (64%) did not have routine mechanisms for recording VAT-related data; however, all participants (100%) stated the importance of sharing data to demonstrate VAT impacts. Time constraints (57%) emerged as one of the major deterrents to data collection or dissemination. The majority (64%) experienced an increased demand or workload for VAT services during the COVID-19 pandemic.

Conclusions:

Despite the global variances in VATs and gaps in VAT-related data, all participants unanimously endorsed the benefits of VAT programs. Evaluating the impact of VATs, disseminating VAT-related data, and forging specialized institutional partnerships for data sharing and training are potential strategies to tackle the hurdles surrounding VAT formation and sustenance.
Chlorhexidine (di)gluconate locking device for central line infection prevention in intensive care unit patients: a multi-unit, pilot randomized controlled trial
Authors: Pook Makena , Zamir Nasim , McDonald Ellen , Fox-Robichaud Alison
Published: July 2022

Purpose:

Intensive care unit (ICU) patients are at risk for central line-associated bloodstream infection (CLABSI) with significant attributable mortality and increased hospital length of stay, readmissions, and costs. Chlorhexidine (di)gluconate (CHG) is used as a disinfectant for central line insertion; however, the feasibility and efficacy of using CHG as a locking solution is unknown.

Methods:

Patients with a central venous access device (CVAD) in situ were randomized to standard care or a CHG lock solution (CHGLS) within 72 hours of ICU admission. The CHG solution was instilled in the lumen of venous catheters not actively infusing. CVAD blood cultures were taken at baseline and every 48 hours. The primary outcome was feasibility including recruitment rate, consent rate, protocol adherence, and staff uptake. Secondary outcomes included CVAD colonization, bacteraemia, and clinical endpoints.

Results:

Of 3,848 patients screened, 122 were eligible for the study and consent was obtained from 82.0% of the patients or substitute decision makers approached. Fifty participants were allocated to each group. Tracking logs indicated that the CHGLS was used per protocol 408 times. Most nurses felt comfortable using the CHGLS. The proportion of central line colonization was significantly higher in the standard care group with 40 (29%) versus 26 (18.7%) in the CHGLS group (P=0.009).

Conclusions:

Using a device that delivers CHG into CVADs was feasible in the ICU. Findings from this trial will inform a full-scale randomized controlled trial and provide preliminary data on the effectiveness of CHGLS.

Trial Registration:

ClinicalTrials.gov Identifier NCT03309137, registered on October 13, 2017
Understanding the Lightning Impulse Discharge Characteristics of Nano Silica Modified Sunflower Oil for High-Voltage Insulation Applications
Authors: S. Chandrasekar
Published: July 2022

Vegetable oils with nanotechnology added to them are a possible replacement for mineral oils in power transformer applications today. Because of the size and production cost reductions as well as the oil's high level of biodegradability, this could result in an increase in the dielectric strength of insulating fluid. Since transformers are mainly used for outdoor applications, understanding the capability of insulating fluid to withstand lightning discharge is a vital issue. This study used experimental analysis to compare the lightning discharge performance of pure sunflower oil and sunflower oil modified with SiO2 (Nano) at various weight-per-volume concentrations of 0.01 %, 0.05 %, and 0.1 %. This experimental work was conducted with 1.2/50 µs of standard lightning impulse voltage with positive polarity. The result illustrated that the nano-modified sunflower oil had greater lightning impulse withstand strength than the pure sunflower oil.
Synergetic Effect on Electrochemical Performance of Activated Carbon - Multiwalled Carbon Nanotubes Supercapacitor using various Electrodes in Aqueous Electrolyte
Authors: D. Thillaikkarasi  , R. Ramesh
Published: July 2022

An Electrical double-layer capacitor (EDLC) has been fabricated with activated carbon (AC) and multi-walled carbon nanotubes (MWCNTs), which in turn were synthesized from Pongamia pinnata fruit shell and its seed oil, respectively. The activated carbon was produced by the chemical activation process at varying carbonization temperatures from 600-900 °C for 5 hours in N2 atmosphere. The obtained activated carbon had a high surface area of 1170 m2 g-1 and a total pore volume of 0.5907 cm3 g-1. The surface area of MWCNTs was 216.1 2 m2 g-1 and the total pore volume was 1.5067 cm3 g-1. The as-prepared AC and MWCNTs were characterized by surface area analysis using Brunner-Emmett-Teller method (BET), X-ray diffraction analysis (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopic analysis, Field emission scanning electron microscopy (FESEM), High-resolution transmission electron microscopy (HR-TEM), Energy-dispersive X-ray spectroscopy (EDAX) and DFT (Density functional theory). The electrochemical performance of AC-MWCNTs (25:75) Stainless steel (SS) electrode and Graphite sheet electrode (GE) were studied by cyclic voltammetry, Galvanostatic charge-discharge and electrochemical impedance spectroscopy using 0.5 M Na2SO4 aqueous electrolyte. It has shown a specific capacitance of 174 Fg-1 and 95.26 Fg-1 respectively, using the three-electrode system at a current density of 1 mA g-1. The AC-MWCNT (25:75) SS electrode has exhibited excellent specific capacitance (CSP) and its Specific energy density and Power density were greater than AC-MWCNT (25:75) GE. The electrochemical performance of AC-MWCNT (25:75) SS electrode was identified as a suitable, low-cost and promising energy storage device for future generations. The present investigation attempts to promote the supercapacitor device in the context of available and future technologies for alternative energy systems with outstanding performance.
Obturator Internus Bursitis Mimicking Groin Pain in a Football Player: A Case Report
Authors: Sadigale Omkar , Tiwari Anjali , Ramanathan Madhankumar , Choudhury Himanshu , Wadia Farokh , Bagaria Vaibhav
Published: July 2022

Introduction: Traumatic groin pain (GP) is frequently the result of acute trauma, often an indirect muscle injury. The most affected muscles in traumatic GP are the rectus abdominis, adductors, and iliopsoas. The obturator internus bursitis as a cause of GP is very rare. Case Presentation:The present case describes a rare indirect injury of obturator internus bursitis in a 22-year-old male football player who reported GP that used to worsen with sprinting and change in directions. The pain was relieved with rest and sprinting at 80% capacity. The patient had been diagnosed clinically and on magnetic resonance imaging (MRI) as a case of obturator internus insertional tendinopathy with bursitis. His symptoms resolved after ultrasound-guided injection in the inflamed tendon sheath at its insertion point. After 2 years, the patient was followed up with a triumphant return to professional football with no recurrence and a good prognosis in a relatively short recovery time. Conclusion: Clinical diagnosis of obturator injuries is often tricky. GP not responding to conservative management presents a unique challenge to the physician and the rehabilitation team. MRI must follow the radiological investigations and ultrasound if the reports were inconclusive of the diagnosis. In the present case study, the usual causes of such pain (osteitis pubis, and adductor muscle strains/tendinosis) were ruled out, and a specific unique condition was diagnosed with the help of the MRI. Keywords: Bursitis, groin pain, magnetic resonance imaging, obturator internus.
Vibration fatigue life and fracture analysis of 2024-T351 aluminum alloy treated by cryogenic laser peening
Authors: Chen Hansong , Leng Xumin , Xu Yangyang , Meng Xiankai
Published: July 2022

A Nd:YAG nanosecond pulsed laser was used to carry out laser peening and cryogenic laser peening (CLP) experiments at room temperature (25°C) and cryogenic temperature (

−

100

∘

C

), respectively, on the vibration fatigue life of 2024-T351 aluminum alloy. It was found that CLP induced a higher amplitude of compressive residual stress and improved the nano-hardness and the elastic modulus. Compared to the LP-ed samples, the fatigue life of the CLP-ed specimens was higher, and the initiation and propagation of fatigue cracks were more effectively inhibited. Therefore, CLP can effectively improve the fatigue performance of aluminum alloys.
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
Authors: Haass Christian , Selkoe Dennis
Published: July 2022

Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially involved in alternative mechanisms are actually integral to the amyloid cascade. Fluid biomarkers and brain imaging place accumulation of Aβ at the beginning of molecular and clinical changes in the disease. So why have clinical trials of anti-amyloid therapies not provided clear-cut benefits to patients with AD? Can anti-amyloid therapies robustly decrease Aβ in the human brain, and if so, could this lowering be too little, too late? These central questions in research on AD are being urgently addressed.
To what extent naringenin binding and membrane depolarization shape mitoBK channel gating—A machine learning approach
Authors: Richter-Laskowska Monika , Trybek Paulina , Bednarczyk Piotr , Wawrzkiewicz-Jałowiecka Agata
Published: July 2022

The large conductance voltage- and Ca2+-activated K+ channels from the inner mitochondrial membrane (mitoBK) are modulated by a number of factors. Among them flavanones, including naringenin (Nar), arise as a promising group of mitoBK channel regulators from a pharmacological point of view. It is well known that in the presence of Nar the open state probability (pop) of mitoBK channels significantly increases. Nevertheless, the molecular mechanism of the mitoBK-Nar interactions remains still unrevealed. It is also not known whether the effects of naringenin administration on conformational dynamics can resemble those which are exerted by the other channel-activating stimuli. In aim to answer this question, we examine whether the dwell-time series of mitoBK channels which were obtained at different voltages and Nar concentrations (yet allowing to reach comparable pops) are discernible by means of artificial intelligence methods, including k-NN and shapelet learning. The obtained results suggest that the structural complexity of the gating dynamics is shaped both by the interaction of channel gate with the voltage sensor (VSD) and the Nar-binding site. For a majority of data one can observe stimulus-specific patterns of channel gating. Shapelet algorithm allows to obtain better prediction accuracy in most cases. Probably, because it takes into account the complexity of local features of a given signal. About 30% of the analyzed time series do not sufficiently differ to unambiguously distinguish them from each other, which can be interpreted in terms of the existence of the common features of mitoBK channel gating regardless of the type of activating stimulus. There exist long-range mutual interactions between VSD and the Nar-coordination site that are responsible for higher levels of Nar-activation (Δpop) at deeply depolarized membranes. These intra-sensor interactions are anticipated to have an allosteric nature.