bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepcidin Modulators: A Potential Alternative Treatment of Iron Deficiency and Iron Deficiency Anemia in Heart Failure
Authors: Haley Lauren , Hathaway Chase , Irby Jonathan , Klumb Sydney , Cheng Johnny
Published: October 2024

Heart failure affects roughly 6.7 million Americans and is associated with many comorbidities and complications, including iron deficiency and anemia. Iron homeostasis is integral to optimal body function. Hepcidin, a hepatically produced peptide, is a major modulator in iron homeostasis. Its synthesis is induced in part by inflammatory states. Iron deficiency in heart failure is currently diagnosed with the assessment of serum ferritin and percent of transferrin saturation. Iron deficiency in the setting of hepcidin excess in inflammatory conditions, such as heart failure, is discussed in this literature review. Iron deficiency is associated with worse prognosis and poorer outcomes in heart failure patients. Targeted treatment of iron deficiency and iron deficiency anemia may provide improved quality of life and decrease mortality and morbidity among heart failure patients. Current treatment options for iron deficiency and anemia include intravenous and oral iron supplementation, as well as other erythropoiesis-stimulating agents. However, concerns regarding safety have been raised in regards to these options. An emerging possibility for the treatment of iron deficiency in the setting of hepcidin overload is hepcidin modulators, including hepcidin antagonists or inhibitors. This review has addressed iron deficiency and anemia in heart failure and suggests that hepcidin antagonists/inhibitors may provide a viable alternative to the classic treatment methods.
Estimation of Bond Free Energy with Gmx_Mmpbsa in Ndm-1 Complexes
Authors: Eduvan Valencia , Mauricio Galvis
Published: October 2024

We report the values obtained for the binding free energies (ΔGbind) of the complexes: NDM-1-M25 (43.80 kcal/mol), NDM-1-M26 (12.71 kcal/mol), NDM-1-M35 (19.92 kcal/mol), NDM-1-M37 (2.46 kcal/mol) and the reference system NDM-1-Meropenem (-10.09 kcal/mol). These results are based on previous absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, docking, and molecular dynamics calculations performed on a small library of potential NDM-1 enzyme inhibitors reported in the literature. Subsequently, the selected systems were evaluated by the Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) method using the gmx_MMPBSA software. The MMPBSA method has been widely adopted to estimate protein-ligand binding affinities due to its efficiency and high correlation with experimental data. The obtained results suggest that, unlike the reference complex, the studied ligands probably do not bind to the receptor under the simulation conditions, which is in significant agreement with experimental data.
Neonatal physiological and thermal imaging v1
Authors: K. Abbas Abbas
Published: October 2024

The "Neonatal Physiological and Thermal Imaging" protocol outlines a comprehensive approach to monitoring critical physiological parameters in neonates through non-invasive, real-time imaging techniques. This protocol integrates continuous heart rate monitoring via ECG patches, respiratory rate assessment using non-invasive sensors, and core temperature measurement with thermography-compatible skin probes. Additionally, regular metabolic panels, blood gas analysis, and Complete Blood Count (CBC) assessments are conducted to evaluate organ function and metabolic health. The protocol also emphasizes infection control, with strict hygiene practices for sterilizing imaging equipment such as ultrasound probes and thermographic devices. By minimizing handling and ensuring patient comfort, this protocol enhances diagnostic accuracy while promoting neonatal safety in clinical settings. The concurrent use of ultrasound and thermographic imaging further enables detailed organ evaluation, optimizing the early detection of potential complications such as infections, hypothermia, and metabolic imbalances, particularly in vulnerable populations like premature infants.
Non-invasive Detection Method for Bonamia ostreae in Ostrea edulis using the Franklin qPCR machine v2
Authors: M Vythalingam Lavanya , Regan Tim , Bean Tim
Published: October 2024

This is a comprehensive protocol for using the Franklin qPCR (Biomeme Inc.) machine to detect the presence of Bonamia ostreae parasite in European flat oyster (Ostrea edulis). Previous methods relied on sacrificially dissecting animals to perform histology. While sensitive, these methods were destructive and untested animals carrying Bonamia ostreae are not detected. Here, we present a non-invasive alternative method to detect Bonamia ostreae from Ostrea edulis pseudofaeces/faeces using a portable qPCR machine.
Sobre a emergência do conceito de “direitos linguísticos” no arquivo jurídico brasileiro
Authors:   Universidade Federal de Sergipe, Santa Rosa Matos Marcos Paulo , Garcia Costa Carvalho Maria Leônia ,   Universidade Federal de Sergipe
Published: October 2024

Este artigo teórico analisa o desenvolvimento do conceito de “direitos linguísticos” no discurso jurídico brasileiro, destacando sua evolução teórica, defesa política e incorporação na legislação nacional, a partir da noção de “arquivo” proposta pela análise de discurso da tradição francesa. O texto está estruturado em três partes: inicialmente, aborda a contribuição de Francisco Gomes de Matos, cujas listas de direitos e apelos por reconhecimento foram cruciais para a discussão teórica e a mobilização política em prol desses direitos, especialmente no contexto internacional. Em seguida, examina a assimilação dos direitos linguísticos pelas normas jurídicas brasileiras, com ênfase na proteção das comunidades minoritárias (pessoas surdas, indígenas, quilombolas, descendentes de imigrantes e estrangeiras) e na importância da Constituição de 1988 nesse processo. Por fim, discute a proposição de uma disciplina jurídica geral para os direitos linguísticos, representada pelo Projeto de Lei nº 489/2019, que pode constituir um quadro significativo para sua tutela no país. A análise mostra a complexidade e os desafios na efetivação dos direitos linguísticos no Brasil, ao mesmo tempo que reconhece a rica memória de lutas e avanços que sustentam essa causa.
Prácticas Culturales de Estudiantes Migrantes en una Universidad Pública. Un Estudio de Caso
Authors: Campechano-Escalona Eduardo José , Orbegoso-Dávila Luis Alberto , Benites Carranza Gabriela Marisol , Verastegui Acuña Itamar Noemi , Díaz-de-Campechano Isabel Cristina
Published: October 2024

Este artículo explora las prácticas culturales de estudiantes migrantes en una universidad pública peruana para comprender su adaptación e integración académica y social. A través de un estudio de caso con enfoque fenomenológico y entrevistas semiestructuradas, se identificaron tres categorías: adaptación cultural, cambios en prácticas culturales y problemas sociales. Los resultados muestran que los estudiantes migrantes experimentaron cambios significativos en su vestimenta, lenguaje y preferencias culturales al interactuar con la cultura trujillana, adoptando estrategias de integración como redes de apoyo y participación activa. Sin embargo, algunos reportaron experiencias de discriminación y exclusión. El estudio subraya la importancia del ambiente universitario y las iniciativas institucionales para facilitar la adaptación cultural, sugiriendo políticas de inclusión y respeto a la diversidad cultural, alineadas con los principios de la UNESCO y la Agenda 2030, para prevenir la discriminación y favorecer el bienestar y rendimiento académico de los estudiantes migrantes.
An Exploratory Study of Fact-Checking Practices in Conflict and Authoritarian Contexts
Authors: Badji Samba Dialimpa , Orgeret Kristin Skare , Mutsvairo Bruce
Published: October 2024

This study explores fact-checking practices in Ethiopia and Mali in times of conflict and in a context marked by increasing restrictions to press freedom. The objective is to understand how, in this hostile environment, fact-checkers in these two countries manage to carry out their activities. Our findings reveal that fact-checkers are often victims of online bullying and harassment and fear reprisal from governments. This pushes them to self-censor, avoiding working on sensitive topics, such as military issues in Mali. In addition, fact-checking organizations in both countries highlight the difficulty of accessing reliable sources. Consequently, they focus more on debunking viral social media content, thus effectively becoming content moderators who have turned away from the mission of holding leaders accountable, one of the primary functions of fact-checking. Regarding their role conception, fact-checkers in Ethiopia and Mali see themselves more as guides helping navigate the information disorder than “guardians of truth” or “truth keepers.”
Factorial Invariance of Scores on the Patient Health Questionnaire–9 and Generalized Anxiety Disorder–7 With Adults in the United States
Authors: Kalkbrenner Michael T. , Hunt Adam J. , Ryan Aimee F. , Rahman Samiah R.
Published: October 2024

Depressive and anxiety disorders are two common presenting concerns among adults in the United States who seek mental health counseling services. Mental health counselors need screening tools with validated scores for detecting their clients’ symptoms of depression and anxiety. The Patient Health Questionnaire–9 (PHQ-9) and Generalized Anxiety Disorder–7 (GAD-7) are popular screening tools for measuring symptoms of depression and anxiety, respectively. However, the literature is lacking temporally valid research on these popular screening tools, which is concerning, as the psychometric properties of instrumentation can vary substantially over time. We tested the psychometric properties of the PHQ-9 and GAD-7 with a national stratified random sample (N = 1,812) of adults in the United States. The results were promising and begin to address the temporal validity gap in the extant literature regarding the psychometric properties of GAD-7 and PHQ-9. Collectively, findings supported the utility of the GAD-7 and PHQ-9 for enhancing the practice of mental health counselors.
La fragmentación del complejo QRS del electrocardiograma y su correlación con alteraciones cardiovasculares
Authors: Centurión Osmar Antonio , Torales Judith M. , Aquino Nelson J. , García Laura B. , Falcón Rocío del Pilar , Chávez Christian O. , Scavenius Karina E. , Montiel Carmen R. , Sequeira Orlando R. , Meza Alfredo J.
Published: October 2024

La presencia de complejos QRS fragmentados (fQRS) en un electrocardiograma (ECG) de 12 derivaciones de rutina es un marcador interesante de anormalidad de la despolarización. El fQRS representa un retraso en la conducción debido a una activación no homogénea de los ventrículos debido a una cicatriz miocárdica. Sin embargo, la fQRS no es específica de la enfermedad de las arterias coronarias y además se encuentra en otras enfermedades del miocardio como la miocardiopatía y la cardiopatía congénita. fQRS también se há descrito en otras entidades como la miocardiopatía arritmogénica del ventrículo derecho y el síndrome de Brugada. La importancia y el valor predictivo del complejo fQRS como marcador ECG de eventos cardiovasculares parecen ser diferentes en diferentes entidades. En pacientes con enfermedad arterial coronaria estable y en pacientes con infarto de miocardio agudo, la fQRS parece ser un buen predictor de eventos cardíacos. En pacientes con miocardiopatía no isquémica, la fQRS estrecho parece correlacionarse con el grado de fibrosis y disincronía, y podría influir en la respuesta a la terapia de resincronización cardíaca. En pacientes con disfunción del VI, no hay evidencia clara de que la presencia de fQRS pueda predecir eventos arrítmicos. Por otro lado, hubo diferencia estadísticamente significativa en la mortalidad asociada a la presencia de fQRS en pacientes con síndrome coronario agudo y necrosis miocárdica. La presencia de fQRS, posee una alta especificidad y un alto valor predictivo positivo debido a la existencia de trastornos segmentarios de la motilidad miocárdica en pacientes con cardiopatía isquémica.
FRANCHISING YATIRIM MARKASI SEÇİMİNİ ETKİLEYEN KRİTERLERİN SWARA YÖNTEMİYLE DEĞERLENDİRİLMESİ: BİR AKARYAKIT İSTASYONU MARKASI SEÇİM ÖRNEĞİ
Authors: Göncü Kadir Kaan
Published: October 2024

Hizmet üretimi yönetiminde marka seçimi, bir işletmenin başarısını ve sürdürülebilirliğini önemli ölçüde etkileyebilecek kritik bir husustur. Marka bilinirliğine sahip bir işletmenin kendine özgü ürün ve hizmetlerin satılması için verdiği yetki anlamı taşıyan franchising, günümüz dünyasında pek çok işletmenin sıklıkla kullandığı bir yöntem olarak karşımıza çıkmaktadır. Franchising yatırımı yapacak bir işletme için doğru marka tercihini gerçekleştirmek, başlangıç aşamasında kararlaştırılması gereken stratejik bir süreçtir. Bu çalışmanın amacı; franchising türü bir iş yatırım modeliyle girişimde bulunacak bir kişi ya da işletmenin farklı marka ve imajlara sahip franchisorlar arasında tercihte bulunurken dikkate alması gereken spesifikasyonları belirlemek olacaktır. Yüksek maliyetli altyapı ve kurulum giderleri barındıran sektörlerde en doğru franchisoru seçmek yatırım planlamasının başlangıç aşamasını oluşturmaktadır. Çalışmada bir akaryakıt istasyonu franchising yatırım markası tercihini etkileyen faktörleri analiz etmek için, Çok Kriterli Karar Verme (ÇKKV) metotlarından birisi olan SWARA yöntemi kullanılmıştır. Çalışma sonucunda: "Marka" olarak isimlendirilen ve tercih edilen işletmenin alanda bilinirliği olarak tanımlanan kriter, önem değeri en yüksek kriter olarak bulunmuştur.
SAĞLIK HİZMETLERİNDE LİDERLİK KAVRAMI ÜZERİNE YAPILAN ÇALIŞMALARIN VOSVIEWER İLE BİBLİYOMETRİK ANALİZİ
Authors: Gün İbrahim
Published: October 2024

Sağlık hizmetlerinde liderlik kısıtlı sağlık insan gücü kaynağından en iyi şekilde yararlanmayı kolaylaştıran yönetsel bir anahtardır. Başarılı liderler sağlık hizmetlerinin sunulduğu örgütleri etkililik ve verimlilik adına çok iyi noktalara taşımakla kalmazlar, aynı zamanda sağlık profesyonellerinin işlerine ve örgütlerine bağlılıklarında, iş tatminlerinde, motivasyonlarında olumlu etkiler oluştururlar. Sağlık hizmetlerinde liderliğin önemi özellikle kriz zamanlarından sonra daha çok anlaşılmıştır. Son yıllarda yaşanan COVID-19 pandemisi, deprem felaketi gibi sağlık hizmetlerini derinden etkileyen krizler, etkili liderlere olan ihtiyacı gözler önüne sermiştir. Bu kapsamda gerçekleştirilen bu çalışmanın amacı sağlık hizmetlerinde liderlik ile ilgili yapılmış olan çalışmaların bibliyometrik analiz yöntemi ile değerlendirilmesi ve genel görünümünü ortaya konulması amaçlanmıştır. Sağlık hizmetlerinde liderliğin hangi kavramlar ile daha yakın ilişkili olduğu ve gelecek araştırmalarda yazarlara yön göstermesi açısından bu çalışmanın önemli teorik katkılarının olduğu düşünülmektedir. Sağlık hizmetlerinde liderlik literetürnün zaman içerisinde gelişmesi ve uygulamaya dönük önerilerin hayata geçirilmesi ile ortaya çıkan olumlu durumdan gerek sağlık işletmeleri gerek sağlık hizmeti alan hastalar ve yakınları dolaylı olarak olumlu etkilenebilir.
INTEGRATION OF QFD AND DEA METHODS TOGETHER TO PRIORITISE CUSTOMER EXPECTATIONS: THE CASE OF A SERVICE ORGANISATION
Authors: Maruf Muhammed
Published: October 2024

Quality Function Deployment (QFD) is a method used to transform customer expectations into technical requirements and to identify the technical requirements that need to be improved to meet these expectations. QFD stands out as a method that has found wide application in the literature and industry in terms of its advantage in transforming relatively more abstract customer expectations into concrete product and process parameters and its ease of application. One of the most important disadvantages of the method is that in the prioritization of technical requirements related to customer expectations, criteria such as the cost of the technical requirement in question, the implementation time of the necessary improvement activities, etc., are not considered. In this study, an approach in which Data Envelopment Analysis (DEA) methods are applied together with the QFD method to take into account the costs in the prioritization of technical requirements is presented. According to the results of a sample application carried out in a cafe business to test the approach, it is concluded that taking costs into account in the prioritization process should be prioritized in order to meet customer expectations.
Relationship in stages of development with age between living male children and male adults through measurement of sternum bone in Lucknow City of U.P
Authors: Sharma S V , Modi Vimal , Kumar Navneet , Atam V , Verma A K , Kumar P. , Sharma H B
Published: October 2024

The ideal rule of identification of sex and age is a sever need in medico legal cases. Sternum is much more appropriate for detection of sex and age of human beings separately from racial characters.

In present study, our objectives were to find out the age and gender on the basis of sternum length in living male children and adults.

This study has been conducted on the total 100 subjects, 50 male children (02-15 yrs) and 50 male adult (16-60yrs) of healthy people (living children & adults) from general population of north India as well as in and around the Lucknow of Uttar Pradesh. The technique described by Ashley GT -1956b was used for measurement of sternum.

Comparing the mean length, Student’s t test showed significantly different and higher length of manubrium (16.1%) (49.45 ± 3.45 vs. 58.97 ± 6.68, t=8.94, p<0.001) and length of sternum (4.0%) (156.16 ± 5.26 vs. 162.70 ± 5.70, t=5.97, p<0.001) in 16-60 yrs as compared to 2-15 yrs.

The assessment of the relationship in stage of development and sex between living male children and adult through measurement of sternum bone in lucknow city of U.P., significantly different and higher length of sternum, because the growth of sternum segment was completely develop in adult, but the development in children male is continuous in ratio of adults male.
Solution of certain problem with nonlocal boundary condition for
one-dimensional wave equation
Authors: Gasanova E. E. , Pulkina L. S.
Published: October 2024

In this paper, we study a problem with nonlocal boundary condition for one-dimensional wave equation. To prove the solvability of the problem we construct biortogonal basis consisting of eigen- and adjoint-functions of not self adjoint operator.
Modeling of elastic plastic deformation of near-surface layers of materials
Authors: Mekheda V. A.
Published: October 2024

According to the results of strain measurements, a kinematically hardening body model is used to describe the process of elastic-plastic deformation of 1X18H9T steel. Special attention is paid to the processes occurring in the surface layers. The model takes into account the increasing tightness of shear deformations deep into the material. The increase in the stress of the plastic flow in depth is described by a second-order polynomial. The main parameters of the surface effect were determined experimentally and by calculations using the method of reduction coefficients in the process of successive approximations: depth, coefficient of hardening of the material, stresses of plastic flow on the surface and inside the material. It is shown that in order to study the near-surface effect by the strain gauge method, it is necessary to give preference to bending tests of samples rather than stretching. The presence of the surface effect explains the following facts: the destruction of the sample during the tensile test does not begin from the surface, but from the inside, the origin of fatigue cracks occurs under the surface, the surface effect practically does not affect the deformed state of the elastic body, but very strongly affects the stress state at the surface.
Dynamics of the Euler — Bernoully beam with distributed hysteresis
properties
Authors: Karpov E. A.
Published: October 2024

In this paper, we present a new mathematical approach to the analysis of a beam with distributed hysteresis properties. These hysteresis characteristics are described by two methods: phenomenological (Bouc — Wen model) and constructive (Prandtl — Ishlinskii model). The equations for beam are developed using the well-known Hamilton method. We investigate the dynamic response of a hysteresis beam under various external loads, including impulse, periodic and seismic loads. The results of numerical simulations show that the hysteresis beam exhibits differently to external influences as compared to the classical Euler-Bernoulli beam. In particular, under the same external loads, the vibration amplitude and energy characteristics of the hysteresis beam are lower than those of the classical one. These findings can be useful for buildings developers in the design of external load resistant buildings and structures
A simple mechanical model of turbulence
Authors: Semenov M. E. , Tolkachev A. V. , Kanishcheva O. I.
Published: October 2024

This work examines the control and stabilization problems of vibrations in a hierarchical chain of oscillators with hysteresis couplings. Hysteresis coupling is formalized within the Bouc — Wen phenomenological model. The mass, stiffness, and damping properties of the oscillators are set to follow a specific scaling rule and decrease exponentially along the chain, thus forming a hierarchy. The model is verified using Kolmogorov’s hypotheses. To do this, energy spectra are constructed under hysteresis in coupling and without it at different amplitudes of the external excitation. As a result of computational experiments, it is shown that for a chain with hysteresis couplings at a high amplitude of excitation, the energy spectrum curve sufficiently corresponds to Kolmogorov’s hypotheses. The amplitude-frequency characteristics of the system are calculated under hysteresis in coupling using the frequency scanning method. In numerical experiments, frequency ranges of external excitation are identified, which correspond to the chaotic behavior of oscillators and their synchronization.
Two remarks on properties of functions of bounded variation
Authors: Astashkin S. V. , Ershov V. M.
Published: October 2024

In terms of variations, a sufficient condition for the uniform convergence of sequences of continuous functions is proved. Using this result, we obtain an addition to the classical Helly theorem on the selection of convergent sequences of functions with uniformly bounded variations in the case when the limit function is continuous. Also, by using an example we show that the condition of continuous differentiability of a function, ensuring the differentiability of its variation with the variable upper limit, is in a certain sense sharp.
Dynamics of entanglement of qubits in the three-qubit Tavis —
Cummings model with dipole-dipole interaction
Authors: Bagrov A. R. , Bashkirov E. K.
Published: October 2024

The article studies the dynamics of pairwise entanglement of three qubits, two of which are trapped in a resonator and interact with a single-mode ideal resonator through single-photon transitions, and the third qubit is outside the resonator. This takes into account the dipole-dipole coupling between the isolated qubit and the qubit in the resonator. We have found a solution to the quantum nonstationary Schrodinger equation for the total wave function of the system for the initial separable and biseparable states of qubits and the thermal initial state of the resonator field. Using these solutions, the criterion of entanglement of qubit pairs - negativity is calculated. The results of numerical simulation of the negativity criterion have shown that the including of a small dipole-dipole coupling between an isolated and one of the trapped qubits can lead to significant entanglement of qubit pairs for all initial states. There is a transition of entanglement from one pair of atoms to other pairs of atoms during the evolution of the system. It is also shown that for some separable and biseparable states, the dipole-dipole interaction can suppress the effect of sudden death of entanglement
The mass person and their speech roles of a simpleton, a buffoon, a mentor in the Russian prose of the 1920s
Authors: Golubkov Sergey A.
Published: October 2024

The scientific review deals with the understanding of the image of the mass person in the literature of the 1920s. The focus of our attention includes both the actual literary texts of the writers of this decade, as well as fundamentally important studies devoted to this problem. Historical-typological and comparative methods are chosen as leading research technologies. They allow us to study the subjective organization of prose works and create a scientific classification of the most representative phenomena in this field. Modern achievements in narrative theory are taken into account. It is widely known that in the revolutionary breakdown of the entire symbolic system of being the ratio of everydayness and non-everydayness has changed. The role of the public dimension increased, human life went out onto the street, the square, and there was a tilt towards the collectivist "we". An ordinary person found their voice and inevitably became, to some extent, a historical "figure". For writers, this person was of interest as a subject of consciousness and a subject of speech. The range of speech roles of the mass person is quite large. There is a simpleton, and a buffoon, and a joker, and a performer, and a cheat, and a singer, and a limited person, and a fool, and a teaching mentor, and a narrow-minded judge. A mass person represents himself/herself in texts in different ways: 1) in the individual lines assigned to him/her by the author, 2) in detailed monologues, and, finally, 3) in prose. In the latter case comically-colored and holistic forms of fantasy-narrative became extremely active: there was a demand for a narrator figure capable of replacing the traditional figure of an "omniscient" narrator close to the author. This narrator completely subordinates the narrative, and the phraseological point of view of the character who initiated the storytelling event begins to dominate the text. The scientific review deals with the works of M.M. Zoshchenko, P.S. Romanov, A.N. Tolstoy, V.Ya. Shishkov, M.Ya. Kozyrev, Y.L. Slezkin. At the same time, attention is paid to such opposite speech reflections of the mass person as a harmless buffoon who turns every thing and every being around themselves into a theater of life, and a severely instructive mentor, distinguished by speech aggression. All these examples show that the traditional "little person" (familiar from previous literature and becoming a "mass person" in new historical conditions and gaining the status of the initiator of storytelling) does not at the same time acquire proper personal development and reveals his or her stereotypicality and shallowness.
The category of Nothingness as a factor in the aesthetics and poetics of modernist literature
Authors: Zhitko Roman G.
Published: October 2024

The article defines the specifics of the influence of ideas about Nothingness on the artistic philosophy and aesthetics of modernism. It is stated that the feeling of the "liminal" time created an ambiguous perception of the world: the mystical fear of "sinking into Nothingness" together with the "dying" world, the bitterness of the loss of the "former" world were combined with the expectation of an inevitable revival. Nothingness becomes a system-forming factor in the artistic philosophy and aesthetics of modernism. Modernism objects both to Nietzschean concept of the "death of God" and to the rational-pragmatic understanding of being. Modernist reflection on Nothingness means striving for a classical value attitude to the world, manifests the salvation of culture, the human and the divine in man, asserts the idea of the highest (in the ontological and value sense) being. Therefore, the defining position of modernist aesthetics is the assertion of the presence of the Supreme and the Sacred, one of the representatives of which in the text is Nothingness. Theoristsof modernism show interest in various traditions of understanding Nothingness in culture and master them in aesthetics and poetics. The heterogeneity of inherited traditions gives rise to a variety of poetic and philosophical concepts: the focus on cognition of the Unknowable through symbolic imagery, mytho-theurgic constructions as the basis of the “negative aesthetics” of the 20th century were combined with the ontologization of Nothingness in the chronotope of a work of art based on the convergence of archetypal oppositions and theaffirmation of the value of spiritual effort aimed at comprehending the highest meaning of existence. Thus, the category of Nothingness in the aesthetics of modernism acts as the embodiment of the ontological problematic nature of the incomprehensible world, a sign of its epistemological uncertainty, correlating the Absolute and the Incomprehensible with the Beautiful.
The formation of the idea of patient agency at the institute of medicine
Authors: Sotnikov Sergey A.
Published: October 2024

This article is devoted to the topic of patient agency. The aim of this work is to consider the process of formation of the idea of patient agency at the Institute of Medicine. The author of this article, starting the consideration with the concept of the «patient role», authored by the famous American sociologist T. Parsons, shows the trend observed since the second half of the 20th century to move away from the paternalistic model of the «doctor-patient» relationship that was dominant at that time. The article examines the works of such modern researchers as A. Bock. E. Deffos, P.S. Sorokin, A.V. Zykova et al. It is noted that interest in the issue of agency in general and in the agency of patients in particular has increased during the coronavirus pandemic. The emergence of patient agency in recent years has also been facilitated by digital technologies, which began to be used in medicine thanks to the so-called «digital revolution», which, according to researchers, the pandemic has only accelerated. For example, telemedicine and various websites where patients can find the necessary information have begun to actively develop. At the same time, the very concept of agency today does not have an established meaning in scientific circles; there are heated discussions around this concept; the topic of patient agency is promising for research and needs further study.
Управление детонационным горением водородно-воздушной смеси
Authors: Левин В.А. , Журавская Т.А.
Published: October 2024

В работе представлены результаты численных исследований, проведенных с целью определения новых способов управления детонационным горением стехиометрической водородно-воздушной смеси в плоском канале. Предложен ряд конструктивных решений, усиливающих разрушающее воздействие расположенных в канале множественных препятствий на распространяющуюся детонационную волну. Исследовано влияние добавок пероксида водорода и гелия в рассматриваемую горючую смесь на параметры волны детонации с целью снижения температуры продуктов горения без существенного изменения размера детонационной ячейки и уменьшения скорости волны.
Эффективность плазменной технологии подготовки твердых топлив к сжиганию
Authors: Мессерле В.Е. , Орынбасар М.Н , Устименко А.Б.
Published: October 2024

Выполнен термодинамический анализ, позволивший найти рабочие параметры плазменной технологии подготовки твердых топлив к сжиганию. Кинетические расчеты плазменного воспламенения и устойчивого сжигания пылеугольного факела выполнены с использованием программы PlasmaKinTherm. Получены профили температур, скоростей и концентраций горючего газа и угольных частиц по длине реакционной зоны плазменно-угольной горелки. В экспериментах по плазменной подготовке энергетического угля к сжиганию достигнуто устойчивое воспламенение пылеугольного факела, измерены температура и состав полученного высокореакционного двухкомпонентного топлива, а также определена степень конверсии углерода высокозольного Экибастузского угля. Сопоставление результатов экспериментов и расчетов показало их приемлемое согласие. Показано, что основным продуктом плазменного воспламенения и стабилизации горения угля является высокореакционное двухкомпонентное топливо, а концентрации вредных выбросов – оксидов азота и серы при этом меньше, чем в дымовых газах тепловых электростанций на два порядка.
Enhancing E-Mail Marketing by Semantic Addressing
Authors: Rasovic Tanja , Milosevic Danijela , Zoric Zeljko , Milosevic Marjan
Published: October 2024

This paper presents architecture of the software system for semantic e-mail addressing. It explores the possibilities for creating and updating the knowledge base system about employers and job vacancies, which is created based on domain ontologies. It also describes in details the process of publishing database on the Semantic Web and plans for further updating and improving the existing knowledge base system. Due to specific kind of work, and necessity of automating communication with employers, the presented system is applied in the Employment Agency of Montenegro.
Usage of Service-Oriented Architecture for Developing Prototype of Intelligence Information System
Authors: Achkoski Jugoslav , Trajkovik Vladimir
Published: October 2024

The level of technological development in society has influence on implementing contemporary technologies because benefits of using ICT make pressure on increasing level of development in society. In this paper we propose key points of usage of Service-Oriented Architecture for Developing Prototype of Intelligence Information System.
A Fully Personalized Adaptive and Intelligent Educational Hypermedia System for Individual Mathematics Teaching-Learning
Authors: Özyurt Özcan , Özyurt Hacer , Baki Adnan , Güven Bülent , Karal Hasan
Published: October 2024

In this study, architecture and development process of UZWEBMAT, an adaptive and individualized environment based on learning styles and supported with expert system, are presented. UZWEBMAT was developed to teach probability unit of 11th grade mathematics course. Three different contents, which are appropriate to Visual-AuditoryKinesthetic (VAK) learning styles, are presented to learners. Content of each sub-learning style is presented with expert system support. Thanks to this expert system, it is possible for learners with same learning style to take different contents. By this means, highest level of individualized learning environment was tried to be created via UZWEBMAT. Integration of UZWEBMAT to real classroom environment shall be made in future studies. Evaluation of UZWEBMAT and its impact on academic achievements of learners shall be researched.
SPD Change of HP LED Under Increased Temperature Stress
Authors: Softic Amela
Published: October 2024

High power light emitting diodes (HP LED) are energy efficient light sources that have been developing at great speed. Aging process was performed at increased pin temperatures, with approximate values of 80°C, 90°C and 100°C and constant current. The conditions in chambers are simultaneously monitored for approximately 5000 hours. The change in HP LED's SPD was small and for the second test group was within the narrower wavelength interval than for the first. This interval corresponds to the phosphor emission region and indicates that important factor of white LED's SPD stability is the choice of type of phosphor used.
Information Security Threats and Information Assurance
Authors: Yalman Yildiray , Yesilyurt Murat
Published: October 2024

Today, the benefits of rapidly developing technology, as well as come to the fore the problems brought about. For this reason, individuals, institutions and organizations take measures to ensure the security of information. Information assurance is the practice of managing risks related to the use, processing, storage and transmission of information or data and the systems and processes used for those purposes. Thus, information security is now provided with information assurance measures. The presented work, especially in today's digital and networking technologies in order to ensure effective information security threats and describes the scope of what required for information assurance.
Determining Optimal Hourly and Annual Coefficient District Cooling - One of the Aspects use of Green Technology
Authors: Bajmak Sefik M. , Ristovski Aleksandar , Blagojevic Bratislav
Published: October 2024

Work together more cooling source (refrigeration machines) the system of centralized supply cooling energy ( SCSCE ) is a way to achieve cost-effective operation and safe and rational supply consumption area with cool water for central cooling and air conditioning . Maximum energy needs cold water occurs rarely , because the extremely high temperatures occur rarely . Therefore , the total cooling load is divided into basic and peak . One of the main characteristics that define the justification of the use of coupled processes and sizes hourly coefficient centralized supply of cold water, temperature regime , or hour coefficient district cooling . Determination of Optimal hour coefficient district cooling is one of the most techno economic tasks at the design of the system of centralized supply cold water for air conditioning and industrial building social housing and business districts.
Mathematical Model for Optimum Temperature and Humidity Determination of Mashed Mushroom in Greenhouses by using Smart Farm Technology and Innovation
Authors: Sangapate Prisayarat , Sarasit Napaporn , Sanpan Hataikhan , Mekwian Jirapong
Published: October 2024

Background: At the present time, various technologies have been used in the development of modern agriculture. The technology used to help in the development of agricultural farms is called a smart farm. Mashed Mushroom is a food due to their usefulness and high nutritional and good income, as this result, the researcher was interested in the use of technology and innovation of smart farms in the mashed mushroom cultivation house and find a mathematical model of the optimum temperature and humidity for growing mashed mushrooms. Furthermore, find a mathematical model of the yield amount of mashed mushrooms against temperature and humidity. Methods: There are 5 methods in this research, to be composed of studying the problem, planning the operation process, using technology and innovation in smart farms, collecting data and finally finding a mathematical model of the optimum temperature and humidity for growing mashed mushrooms. In addition, a mathematical model of the yield of mashed mushrooms was obtained. Result: The results showed that the mathematical model of the optimum temperature for mashed mushroom was T= 0.3267t3-2.83t2+7.1433t+20, the most appropriate temperature was 24.95±5.557°C at the average andthe mathematical model of the optimum humidity for mashed mushroom was H= -0.8417t3+4.82-0t2.1883t+59.65, the most appropriate humidity was 74.58±15.451% at the average. In addition, the mathematical model of product yield of mashed mushrooms was = -1.479+0.055T+0.028H when temperature T and humidity H were determined.
ANALISIS RANTAI PASOK DAN RANCANG BANGUN SISTEM KETERTELUSURAN KOPI ROBUSTA BERBASIS ANDROID
Authors: Alhabsyi Mohamad Fadel , Pertiwi Setyo , Pujantoro Lilik
Published: October 2024

Robusta coffee is the most widely cultivated coffee commodity in Indonesia. In the East Bolaang Mongondow Regency, the problem at the supplier level is limited market information, which makes the coffee beans' quality inconsistent, impacting the price and product quality image. This research aims to identify supply chain structure models and members, added value, and design a traceability system to support product quality validation. Robusta coffee supply chain participants and their interactions were identified at the Modayag coffee plantation in East Bolaang Mongondow. The data were collected through observations, interviews, and field studies. Supply chain analysis was performed using the Vorst method and the added value was calculated using the Hayami method. The traceability system design follows the system development lifecycle method. The findings indicate that the Robusta coffee supply chain in East Bolaang Mongondow Regency includes farmers, collector traders, processing plants, the retail industry, coffee roasteries, and consumers. Farmers profit from selling perfectly ripe wet coffee beans 42-43%, wet mixed coffee beans (8%), and dry mixed coffee beans 63-71%. A traceability system named Kinton was successfully developed and integrated with the Firebase database to store all information.
Investigation of local soil properties of Erzurum province (Eastern Türkiye) by Horizontal/Vertical Spectral ratio method
Authors: Sarigül Şeyma , Bayrak Erdem
Published: October 2024

Erzurum province is a basin developed under the effect of strike-slip faults in the Eastern Anatolia region. Erzurum province is generally influenced by the left strike-slip Erzurum Fault Zone, the left- strike-slip Aşkale fault, and the Başköy-Kandilli reverse fault. It is also located approximately 80 km from the Karlıova joint, which is the intersection of the North Anatolian and East Anatolian Faults. When the earthquakes of the instrumental and historical periods are analyzed, it is seen that many damaging earthquakes of medium to large magnitude have occurred in Erzurum province. Erzurum basin is generally covered with old alluvium at the edges of the plains, while the flat areas in the central parts are covered with new alluvium. Determination of local soil properties in regions with high earthquake hazard plays an important role in reducing earthquake risks. For this purpose, single station microtremor measurements were applied at 25 sites in Palandöken and Yakutiye districts of Erzurum province. The measurements were taken for at least 30 minutes and evaluated according to the Horizontal/Vertical Spectral Ratio method. As a result of the analysis, the dominant period, H/V ratio and vulnerability index (Kg) values of the measurement points were calculated. The period values obtained vary between 0.15 s and 3.7 s, while the H/V ratios vary between 2.2 and 8.5. The Kg value obtained using these parameters is defined as the vulnerability of the soil. It is concluded that high period, high H/V and high Kg values are obtained in areas with recent alluvium and multidisciplinary analyses should be performed in soil investigations in these regions.
KADERİ KESİŞEN İKİ ARKETİP: EMMA BOVARY İLE BİHTER ZİYAGİL
Authors: Yaşar Hüseyin , Özmen Tuba
Published: October 2024

Kadın mevzusu her dönemde farklı şekillerde edebiyatta işlenmiştir. Edebi eserlerde önceden bir nesne olarak yer alan kadın, Aydınlanma Çağı ve sonrasında gelen Sanayileşme Devrimi ile beraber bir özne olarak yer almıştır. 19. asırdan sonra Avrupa romanında kadın, ferdî ve toplumsal bir varlık olarak olay örgüsünde işlenmiştir. Birçok romanda ise kadın, merkez karakter konumundadır. Bu çerçevede Madam Bovary romanındaki Emma Bovary karakteri, görüşleri, hayalleri Gustave Flaubert tarafından dikkate alınan bir kadındır. Romanda Emma; etkilenen, terk edilen ve aciz bir kadından öte etkileyen, terkeden ve etkin bir şahsiyettir. Bu değişimin Tanzimat ile beraber Türk romanını da etkilediği saptanmıştır. Halit Ziya Uşaklıgil de Aşk-ı Memnu romanında Bihter Ziyagil karakterini benzer çizgilerle kurgular. Emma Bovary gibi Bihter de terkeden ve etkin olmanın sonucu olarak toplumsal hayata karışır. Emma ve Bihter hayallerinin peşinde koşan, yerleşik âdetleri çiğneyen kadınlardır. Toplumsal hayatta belli bir ayar tutturamayan Emma ve Bihter, ihtiraslarının ve lüks hayata düşkünlüğünün yansımasının sonucu kocalarına karşı sadakatsiz davranırlar. Kahramanların başına gelenler açısından tespit edilen benzerliklerle birlikte her iki romanın ilk basımları sırasında yaşanan serüvende de aynı ilgiler bulunmaktadır. Her iki roman, toplumun genel ahlakına mugayir olduğu gerekçesiyle kovuşturmalar geçirmiş ve baskıları gecikmiştir. Bu çalışma mukayeseli bir çalışmadır. Çalışmada her iki roman, başkahramanlar düzleminde mukayese edilmiş ve söz konusu romanların gerek benzer gerekse farklı yönleri saptanmıştır.
Epidural lumbar pneumocysts and radiculopathy: description of a clinical case of diagnosis and treatment
Authors: Larionov S. N. , Zhivotenko A. P. , Vel'm A. I. , Sorokovikov V. A.
Published: October 2024

Epidural pneumocysts are a rare but significant cause of severe low back pain in patients. A clinical case of diagnosis and treatment of this disease, which often remains poorly studied in the literature, is presented. It should be noted that descriptions of nerve root compression by a gas bubble are found in both domestic and foreign publications, but they are rare, which makes the problem relevant and interesting for the medical community.
A case of treatment of chronic constrictive pericarditis of tuberculous etiology
Authors: Tarasov R. V. , Krasnikova E. V. , Cadovnikova S. S. , Prokhodtsov D. N. , Khozikov A. S. , Bagirov M. A.
Published: October 2024

An observation from practice is given tuberculous constrictive pericarditis, which has been occurring for a long time with symptoms of polyserositis without identifying of etiology. The recurrent course of the disease, the constant accumulation of effusion in the abdominal and pleural cavities was the basis for the diagnosis: "compressive pericarditis complicated by calcification of unknown genesis and of constant patronage of cardiologists. Considering the tuberculous process suffered more than 10 years ago, to exclude the tuberculous etiology of polyserositis, the patient underwent pericardial resection. According to the results of microbiological examination of the surgical material, the tuberculous nature of pericarditis was established, however, according to the results of histological examination, no foci of necrosis and granuloma elements were found. The clinical case demonstrates the complexity of the diagnosis of tuberculous constrictive pericarditis with the phenomena of pronounced polyserositis, which was detected only as a result of diagnostic surgery: partial excision of the pericardium.
Complexities in diagnosis and treatment of medullary thyroid cancer. Clinical observation
Authors: Frolova E. V. , Naumova N. N. , Salautin E. V. , Volodina E. A.
Published: October 2024

This article discusses the etiology of sporadic and hereditary forms of medullary thyroid cancer (MTC), diagnostic criteria that allow the most accurate and accurate diagnosis and differentiate it from similar symptoms, morphological changes in MTC, which is one of the least studied due to the peculiarities of its histogenetic genesis and low frequency of treatment of the population with this a problem. MTC is often diagnosed at the time of planned hospitalization of patients for problems in a related area, but not directly related to thyroid cancer. In this article, clinical manifestations presented in a specific clinical case are investigated, markers of immunohistochemical studies are determined. This case is interesting and unusual for the duration of the patient's treatment, as well as successful surgical interventions that were aimed at removing multiple metastases. To date, the number of referrals from patients with minimal structural and functional changes in the thyroid gland is small, which indicates that the disease is often diagnosed at a later date. In the minds of a certain percentage of the population, the idea of a possible self-healing of the body is firmly fixed, which is often decisive with the progression of the disease (especially with a sharp jump in progress, for example, after a general somatic decrease in the immune response after infectious diseases, hypothermia, radiation exposure). This article is indicative in this matter – it clearly demonstrates the need for timely vigilance and care for the body, timely medical examination of the population and attentive attitude in particular to the thyroid gland.