bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Kompensasi Dan Motivasi Kerja Terhadap Kinerja Karyawan PT. Sinar Suri Toyota
Authors: Sabarofek Margareth Sylvia
Published: August 2021

PT. Sinar Suri Toyota is located in Manokwari Regency, West Papua Province. The research objective was to see whether compensation and work motivation had an effect on employee performance. This type of research is associative research using a quantitative approach method. The population is all employees in the workshop who work at PT. Sinar Suri Toyota Manokwari with a total of 32 people. However, at the time of data collection, there was a pandemic Covid-19 so that data retrieval via google was from. The data analysis technique used is multiple linear regression. To see the effect of the independent variable compensation and work motivation on the dependent variable employee performance through hypothesis testing. There are two ways used to measure the independent and dependent variables based on the t test and the F test. From the research results based on the parti al test (t test) for the variable compensation and work motivation on employee performance. For a significant value smaller than the error error (0.000> 0.05) and a significant value smaller than the error error (0.032> 0.05, so that H0 is rejected and Ha is accepted, meaning that partially the compensation and work motivation variables have a significant effect on the variable Employee performance While simultaneous testing (F test) of compensation and motivation variables on employee performance variables with a significant value smaller than the error error (0.000> 0.05) so that H0 is rejected and Ha is accepted, meaning that simultaneously, compensation and motivation greatly affect employee performance.
Analisis Faktor Yang Mempengaruhi Financial Saticfaction Pada Dosen Di Universitas Papua
Authors: Said Agustia , Nurwidianto  , Dedi Selmi
Published: August 2021

The purpose of this study is to know whether financial knowledge, financial capability and financial behavior in partially and simultaneously that have affect to financial saticfaction. Then, to know which is most dominant factor that effect to financial saticfaction. The type of this research is quantitative that using numerical data to analyzed. The sample in this research is using proportionate stratified random sampling. Which is technique of collecting the data that using questionare distributed to lecturer at Universitas of Papua counted 83 samples. The data were analyzed using validity and reliability test, classic assumption test, multiple regression analysis (determination coefficient test, F tes and T Test) with SPSS 21 software support. The results of this study showed that the variables of financial knowledge and financial behavior influenced partially to financial saticfaction. While financial capability does not effect partially to financial saticfaction. Simultaneously, financial knowledge, financial capability and financial behavior have an effect to financial saticfaction. Then, the most dominant variable of financial behavior is affect to financial saticfaction.
Pengaruh Lokasi, Pendapatan Konsumen, Harga Rumah Dan Selera Terhadap Keputusan Pembelian Rumah Bersubsidi Di Kabupaten Manokwari
Authors: Walalayo Noviani , Yap Rumas Alma , Orisu Lillyani M.
Published: August 2021

This study aims to determine the influence of location, consumer income, house prices, appetite for subsidized home purchase decisions in Manokwari Regency. The variables in this study are Location, Consumer Income, House Price and Taste. This study uses primary data and secondary data. Primary data obtained through questionnaires and secondary data obtained through agencies related to this study, the analysis method used is to use multiple linear regression models using the SPSS Statistic 16 program. The results of the partial study (t test) Location, Kosumen Income, House Prices and tastes had a positive and significant effect on the decision to purchase subsidized homes in Manokwari Regency. But together (simultaneously) variable locations, consumer income, house prices and tastes significantly influenced purchasing decisions at a confidence level of 95 percent.
Pengaruh Kualitas Produk, Iklan, Elektronic Word Of Mouth Dan Citra Merek Terhadap Minat Beli Smartphone Oppo (Studi Kasus Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Papua)
Authors: Siagian Karina Monica Ersada , Bopeng Louis S. , Bajari Makarius
Published: August 2021

This study aims to determine the influence of product quality, advertisements, electronic words of mouth, and brand image on Oppo smartphone buying interests. This is a quantitative research with survey method. The population in this study are students of the Faculty of Economics and Business, Universitas Papua, with sample of 105 respondents, determined by the non-probability sampling technique. The analytical method used is the validity test and the reliability test using Cronbach's Alpha. The analysis technique used is the hypothesis and the multiple linear regression. The results of this study partially indicate that (1) a product quality has no effect on Oppo smartphone buying interest, as evidenced by the t-value of -0.662 and the significant value of 0.536 > 0.05, (2) advertisements have no effect on Oppo smartphone buying interest, as evidenced by the t-value of 1.067 and the significant value of 0.289 > 0.05, (3) electronic word of mouth has a positive effect on Oppo smartphone buying interest, as evidenced by the t-value of 4.999 and the significant value of 0.000 < 0.05, (4) and brand image has a positive effect on the Oppo smartphone buying interest, as evidenced by the t-value of 4.934 and the significant value of 0.000 < 0.05. The results of this study simultaneously indicate that product quality, electronic word of mouth and brand image have a positive effect on the buying interest of Oppo smartphone with a significant value of 0,000 < 0.005
Faktor - Faktor Yang Mempengaruhi Pendapatan Tenaga Kerja Perempuan Di Sektor Informal (Studi Kasus Pedagang Pasar Sanggeng Manokwari)
Authors: Kaiway Framintolia , Bauw Siti Aisah , Maspaitella Marcus R.
Published: August 2021

Women act as wives and even mothers for children in the household by carrying out domestic tasks at home to take care of and serve their husbands and family members. When women have many dependent needs in the family, women take on a dual role to be absorbed in the world of work in the informal sector as traders by trading in the market in order to generate income in order to meet the needs of family life. This study aims to analyze the factors of age, working hours, education level, and the number of dependents on the income of female traders in Sanggeng Manokwari Market by using multiple linear regression analysis tools. The regression results show that there is a significant effect of age and working hours on the income of female traders, while the level of education and number of dependents does not show a significant effect on the income of female traders in the Sanggeng Manokwari Market.
Pengaruh Pendidikan Dan Kesehatan Terhadap Pertumbuhan Ekonomi Di Kabupaten Teluk Bintuni Periode 2010-2018
Authors: Akbar Dody , Awom Sarce B. , Bauw Siti Aisah
Published: August 2021

This study aims to determine the effect of education and health on economic growth in Teluk Bintuni Regency for the 2010-2018 period. This type of research is quantitative research. This research uses time series data and secondary data collection techniques. Analysis of the data using the Coefficient of Determination Test Heteroscedasticity Test f Test t test. The results of this study show (X1) Education and (X2) Health have a positive and significant effect on (Y) Economic Growth.
Analisis Persepsi Pengunjung Terhadap Ketersediaan Produk Wisata Di Pantai Sauwmyen Distrik Oransbari Kabupaten Manokwari Selatan
Authors: Kawey Bartolomeus , Yap Rumas Alma , Mansim Naftali
Published: August 2021

Tourism products are an important part of the development of tourism sector. the real conditions of tourism products in the form of tourist attractions, facilities, at the location of the tourism attraction at the Sauwmyen beach re not very supportive for tourist activity. this condition will certainly greatly affect the experience and comfort travel. This study aims to determine the perceptions of tourists about the condition of tourism products and the comfort of tourist visitors obtained during a trip to Sauwmyen Beach, Oransbari district, South Manokwari Regency. Frequency distribution analysis technique, Customer Satisfaction Index (CSI) and the IPA (Import and Performance Analysis) approach were used as analysis methods. Result showed that the availability of tourism product in the form of tourism attraction excitability and adequate facilities are not fully found at the location of tourist object, there for their result of data analysis show that respondents’ perceptions of tourism product at tourist object are less satisfied. Then according to reality then the comfort of tourist visitors while in tourist sites is less satisfied. Then the strategy is the need for the development of sauwmyen beach tourism object by local residents and the government to improve performance, indicator tourism product that have a primary need for visitors and can be seen in the respondents of each individual in terms of their interest and performance for the development of a better Sauwmyen beach tourism object in the future to be used by all tourists.
Pengaruh Pengelolaan Alokasi Dana Desa Terhadap Kesejahteraan Masyarakat: Studi Kasus Pada Kampung Sumber Boga Distrik Masni Kabupaten Manokwari
Authors: Mualim Mus , Maspaitella Marcus R.
Published: August 2021

The concept of development in Indonesia is an effort to increase equitable distribution of development and its results through sectoral policies and community performance, especially in rural areas. To prosper the village community, the government issued a special budget for villages through the Village Fund Allocation (VFA) to increase community independence, including the Sumber Boga Village. The amount of VFA for Sumber Boga Village naturally should be followed by an increase in the welfare of the community. This study aims to analyze the effect of the management of VFA on the welfare of the community in Sumber Boga Village, Masni District, Manokwari Regency. The type of research used is qualitative and descriptive research using 88 heads of families as respondents obtained using purposive sampling technique. Regression analysis was carried out and the results show that either partially or simultaneously, all independent variables affect people's welfare.
Determinan Permintaan Jasa Kesehatan BPJS (Studi Kasus: Puskesmas Wosi Kabupaten Manokwari)
Authors: Kwando Barce S. , Rahayu Yuyun P. , Semet Maria M.
Published: August 2021

Purpose of this study was to determine and analyze the effect of income, number of dependents, and premium prices on the demand for BPJS health services at Wosi Health Center, West Manokwari District, Manokwari Regency. The analytical method used is the quantitative descriptive analysis method with interview guides and questionnaires as instruments. Data analysis was performed using multiple linear regression analysis. The results showed that simultaneously the income variable, the number of dependents, and the premium price, had a significant effect, while partially only the number of dependents had a significant effect on the demand for BPJS health services at the Wosi Health Center.
Peran Konektivitas Dalam Pembangunan Ekonomi Kepulauan Provinsi Maluku Utara
Authors: Yetty  , Amin Chairullah , Waibot Zulkifli
Published: August 2021

The study emphasizes the importance of connectivity in the economic development of the islands of North Maluku province. The research method uses path analysis techniques to explain the causal relationship between connectivity variables, inflation, economic growth, and poverty. The results show a negative relationship between inflation and economic growth, a positive relationship with economic growth, a negative relationship between economic growth and poverty, and a negative relationship between connectivity and poverty. The results emphasize the importance of developing connectivity in archipelagic areas with a high level of vulnerability in their economic development.
Investigating the vertical displacement of Duhok embankment Dam: A 31- Years Case Study
Authors:   College of Engineering, University of Duhok, Iraq, M.Salim Sarmad Abdullah , Adam Sarhat Mustafa ,   College of Engineering, University of Duhok, Iraq
Published: August 2021

The paper studies the long-term settlement behaviour of more than 30-year of the Duhok dam. The dam uses as the major lake for water supply to the city of Duhok and nearby areas. High-precision levelling was used to measure the deformation of the dam to monitor vertical displacements. Five survey campaigns were conducted over 30-year duration: 1988, March 1990, June 1999, March 2017 and February 2019. Analysis of the results found that the highest downward displacement of roughly 20.4 cm was witnessed between 1988 and 2019 for a monitoring point (BM24) located centrally along the bank of the dam. On the other hand, the highest vertical movement of roughly 1.5 cm was estimated between 1990 and 2019 at the monitoring point (BM27) on the west side of the dam. The monitoring point (BM24) had the highest average absolute movement of about 6.0 mm (per year) over the 31 years. Detailed results and analyzes are presented in this article.
Minimum Spillage from Reservoirs using Mixed Integer Linear Programming
Authors:   College of Engineering -University of Mosul, Iraq, Almohseen Kamel A.
Published: August 2021

The use of the traditional linear programming is not possible when an if-condition is to be imposed on the model unless some modifications are made. The difficulty arises due to the fact that the inclusion of if-condition to the generic formulation of the linear programming and its mechanism called "simplex method" is not a trivial task. The mixed integer linear programming seems to be a good candidate to achieve this goal. However, two issues should be satisfied beforehand if one would like to minimize the spill. 1. the reservoir should be full up to the spillway crest level in order for the spillage to occur. 2. the next state of the reservoir after the spill has been occurred should be full as well. Adding binary integer variables to the model helps in achieving the optimal solution in terms of minimum sum of spillage without violating any of the underlying constraints. When the input to the model being altered, the results showed that the model can cope with the uncertainty inherent in any natural inflow process in terms of spillage minimization.
Data Mining dalam Pengelompokan Penyakit Pasien dengan Metode K-Medoids
Authors: Iswavigra Dwi Utari , Defit Sarjon , Nurcahyo Gunadi Widi
Published: August 2021

Penyakit merupakan suatu kondisi di mana pikiran dan tubuh mengalami semacam gangguan dan ke tidaknyamanan bagi yang mengalaminya. Semakin hari, jumlah pasien di Puskesmas Kuok semakin meningkat dengan beragam jenis penyakit yang berbeda-beda. Peningkatan jumlah pasien mengharuskan staff Puskesmas Kuok harus selalu memperbaharui data rekam medis pasien. Data rekam medis pasien ini berupa laporan yang berisikan jumlah pasien dan penyakit yang diderita. Berdasarkan data tersebut, pihak Puskesmas perlu untuk mengetahui informasi tentang penyakit yang paling rentan dan banyak diderita pasien. Penelitian ini bertujuan untuk mengelompokkan data penyakit pasien untuk mengetahui penyakit yang paling banyak diderita oleh pasien di Puskesmas Kuok Kabupaten Kampar. Pengelompokan data penyakit pasien dilakukan dengan tahapan Data Mining Clustering dan dilanjutkan dengan tahapan metode K-Medoids. Selanjutnya, di lakukan pengujian cluster menggunakan  Silhouette Coefficient. Hasil penelitian ini menunjukkan bahwa pada cluster 1 penyakit yang paling banyak diderita oleh pasien adalah penyakit Diabetes Melitus tidak bergantung Insulin (tipe II) dengan total kasus sebanyak 435 kasus. Pada cluster 2,  penyakit yang paling banyak diderita oleh pasien adalah penyakit Hipertensi Esensial (Primer) dengan total kasus sebanyak 2785 kasus. Untuk cluster ke 3, penyakit yang paling banyak diderita oleh pasien adalah penyakit Vulnus Laseratum, Punctum, dengan total kasus sebanyak 328 kasus. Dari hasil cluster yang diperoleh, maka didapatkan hasil pengujian Silhouette Coeficient sebesar 0,900033674.
Perangkingan Potensi Guru dalam Penentuan Calon Kepala Sekolah Menggunakan Metode TOPSIS
Authors: Wardana Bendra , Sumijan S
Published: August 2021

Efforts to increase the value of the quality of education for students as the next generation of the nation require teachers who have competence in providing education to students. The competence of a teacher can be assessed when a teacher has carried out his duties in accordance with the standard provisions he has. The ranking of potential teachers is used to motivate teachers to be active in carrying out each activity and is expected to have a positive effect on their work to face challenges in this era of globalization. The data that is processed for the ranking of teacher potential is the assessment data of elementary school teachers sourced from the korwildik of the Batang kapas sub-district. This ranking is based on several criteria and weights are determined. Furthermore, this ranking is processed using a system created by the researcher. This ranking uses a method called TOPSIS to assist researchers in ranking. The TOPSIS method is a multi-criteria decision support method with the principle that the chosen alternative must have the closest distance from the positive and negative ideal solutions. The results of ranking with the TOPSIS method are able to support the ranking decisions of potential teachers using predetermined criteria. So that the highest value is found in the 5th alternative with a value of 0.7321 and the lowest value is found in the 1st alternative with a value of 0.2218. The ranking of potential teachers has proven to be able to help the South Coast District Education and Culture Office, especially the korwildik of the Batang kapas sub-district in determining prospective school principals.
Sistem Pakar dalam Menganalisis Defisiensi Nutrisi Tanaman Hidroponik Menggunakan Metode Certainty Factor
Authors: Febrina Yerri Kurnia , Defit Sarjon , Nurcahyo Gunadi Widi
Published: August 2021

Saat ini sistem Pakar telah menjadi bidang penelitian bagi ilmuwan komputer juga ilmuwan pertanian untuk aplikasi dalam berbagai pengembangan informasi. Sistem Pakar dapat dirancang untuk mensimulasikan satu atau lebih dari cara seorang ahli pertanian menggunakan pengetahuan dan pengalamannya dalam membuat diagnosis dan meneruskan rekomendasi yang diperlukan terkait defisiensi nutrisi. Defesiensi nutrisi adalah kekurangan bahan makanan untuk kelangsungan hidup pada tanaman. Kandungan hara pada bagian tanaman, terutama didaun, sangat relevan digunakan untuk mengidentifikasi defisiensi nutrisi. Memberikan hasil diagnosis defisiensi nutrisi kepada petani untuk dapat menjadi patokan perbaikan hara tanaman serta pemberian nutrisi yang baik untuk tanaman hidroponik. Data yang digunakan adalah data defisiensi nutrisi dan gejala serta solusi pemberian nutrisi yang diperoleh dari data petani pada Dinas Pertanian Kota Payakumbuh. Metode yang dipakai dalam system pakar ini adalah metode Certainty Factor (CF). Metode ini memberikan diagnosis berupa kepastian atau ketidakpastian kondisi dalam rule yang digunakan untuk menyimpulkan. Hasil dari pengujian terhadap metode ini menunjukan sebanyak 12 defisiensi nutrisi yang terdeteksi dengan 41 gejala yang dialami. Sehingga dapat mengukur tingkat defisiensi nutrisi yang terjadi. Sistem Pakar dalam Menganalisis Defisiensi Nutrisi Tanaman Hidroponik Menggunakan Metode Certainty Factor dapat menunjukkan bahwa prediksi hamper 94% akurat.
The Geographical Analysis of the Results of Parliamentary Elections in 1990
Authors: Blažek Jiří , Kostelecký Tomáš
Published: August 2021

The article deals with the geographical analysis of parliamentary elections in 1990. Similarity in electoral results have been appraised by cluster analysis. For 8 most important political parties regress equations have been constructed. Ten sociogeographlc characteristics of 76 districts' population were used as independent variables.
Basic Types of Rivers in the Labe Drainage Area
Authors: Zajíček Václav
Published: August 2021

The paper describes the basic types of rivers and watersheds whose features manifest themselves markedly in the river system of the Czech part of the river Labe. The types are demonstrated on four rivers with reference to possibilities of application in other regions. The significance of the differentiation of the types was shown on practical water engineering tasks.
The Czechoslovak Towns with Intensive Interrelations
Authors: Bína Jan
Published: August 2021

The growth of regular sociogeographic relations among towns is a new feature of the settlement structure of Czechoslovakia. The paper deals with couples of towns, which show relatively advanced relations in mutual commuting both to work and to services.
The Need of a Complex Approach to the Investigation of Soil Erosion
Authors: Kliment Zdeněk
Published: August 2021

The paper is a contribution to the regional investigation of soil erosion and refers to the necessity of a complex approach. Its tenor is the synthesis of the knowledge in a region.
The SWANs/ABLES Project: A resource developed by and for teachers to support the teaching and learning of students with additional learning needs
Authors: Kamei Toshiko
Published: August 2021

The inclusion of students with additional learning needs in schooling is part of policy and practice in Australia. However, it has been well documented that teachers lack the resources and training to meaningfully include students with additional learning needs in the full range of learning in their classrooms. The SWANs program of work aimed to fill this gap through the development of assessments based on learning progressions that provide teachers with targeted information to support the teaching and learning of all students including students with additional learning needs. The development and implementation of the SWANs/ABLES suite of resources illustrates how a practical assessment tool can support teachers to target the learning of students with additional learning needs regardless of their point of readiness to learn.
Lesions in the Hippocampus and Substantia Nigra of Wistar Rats’ Brains Induced by Organophosphate Insecticide
Authors: Zaalan Ebtihajah , Qassem Mahmoud , Bilal Muhammad
Published: August 2021

As little is known about the neurotoxicity of the histological structure of the brain, this study focuses on the histological side of four- to six-month-old adult Wistar rat brains, which were examined after 0.1 mg\g organophosphate had been administered orally. In this study, the lesions were mainly localized at the hippocampus and substantia nigra (compacta pars) region. Distinct areas of necrotic and apoptotic tissues were detected in the CA1, CA2, and dentate gyrus of the hippocampus and compacta pars of the substantia nigra. Programmed cell death in the dentate gyrus was observed as early as 72 hours after treatment and necrosis of some brain regions. Moreover, Lewy bodies were noticed in the compacta pars of the substantia nigra. The most important symptoms of parkinsonism were observed in the substantia nigra (compacta pars). These were decreased neurons, increased neuronal melanin in the neurons, and increased glial cells. The degeneration of some neurons was reported in the polymorphic and pyramidal layers. The data showed an increase in the density of the axon membrane and several changes to the axis structure, such as the disappearance of the myelin sheath in some areas along the axis.
ASPECTS OF COMMUNITARY-ACQUIRED CLOSTRIDIUM DIFFICILE INFECTION IN DOLJ COUNTY, ROMÂNIA
Authors:   University of Medicine and Pharmacy, Craiova, Dragonu Livia ,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova, Cupsa Augustin ,   University of Medicine and Pharmacy, Craiova,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova, Bobarnac Ana ,   Public Health Department Dolj, Romania, Dumitrescu Florentina ,   University of Medicine and Pharmacy, Craiova,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova, Giubelan Lucian ,   University of Medicine and Pharmacy, Craiova,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova, Niculescu Irina ,   University of Medicine and Pharmacy, Craiova,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova, Stoian Andreea Cristina ,   University of Medicine and Pharmacy, Craiova, Diaconescu Iulian ,   University of Medicine and Pharmacy, Craiova,   Hospital for Infectious Diseases and Pneumology “Victor Babes”, Craiova
Published: August 2021

Long regarded as a hospital-associated and antibiotic use infection, Clostridium difficile infection (CDI) has seen an increasing incidence as a community-aquired infection over the last decade. Objectives. The paper follows the particularities of CDI with a community onset, depending on the community or nosocomial origin of the infection. Material and method. Three-year retrospective study (July 1, 2014 – June 30, 2017) of 767 confirmed cases with primary CDI, hospitalized in medical units in Dolj county (România). Two groups of patients with community-onset CDI were analyzed: CA-CDI group with community origin of the infection, and NA-CDIc group with nosocomial origin. Results. CDI with community onset was identified in 453 patients (59.1% of the total); of these, 106 (23.4%) had community origin (CA-CDI) and 305 (67.3%) nosocomial (NA-CDIc). CA-CDI has increased from 4.3% (2014) to 17.9% (2017) of the total CDI, with an average of 13.1% for the study period. Compared to hospital acquired CDI, patients with community-acquired infection were younger (median age 57 years vs 65 years), more frequently women (58.4% vs 46.2%), with lower exposure to antibiotics (75.4% vs 85.9%), lower associated immunodepression (4.7% vs 18.6%) and mortality (0.9% vs. 5.5%). Conclusions. CDI epidemiology is dynamic, the actual size of community infection requiring further assessment. CA-CDI should be considered in the investigation of community diarrhea, even in the absence of traditional risk factors (hospitalization, advanced age, antibiotic treatment).
ASSOCIATED DISEASES IN ROTAVIRUS GASTROENTERITIS IN CHILDREN HOSPITALIZED IN CLINICAL INFECTIOUS DISEASES HOSPITAL OF CONSTANTA
Authors:   Clinical Hospital of Infectious Diseases, Constanta, Romania, Diaconu Simona , Cambrea Simona Claudia ,   Clinical Hospital of Infectious Diseases, Constanta, Romania,   Ovidius University, Constanta, Romania, Petcu Lucian Cristian ,   Ovidius University, Constanta, Romania, Rugina Sorin ,   Clinical Hospital of Infectious Diseases, Constanta, Romania,   Ovidius University, Constanta, Romania
Published: August 2021

Our study included 505 children hospitalized in the Clinical Hospital of Infectious Diseases Constanta in 2011-2012 with gastroenteritis with rotavirus. We analyzed the medical records of the patients and extracted demographic data, temperature, and frequency of vomiting and diarrheic stools. We divided the group of cases into 4 groups associated with: respiratory disease (RD) – 160 cases, digestive disease (DD) – 52 cases, eruptive disease (ED) – 11 cases, and a group without other associated diseases (simple) – 282 cases. We found significant differences between the four groups regarding the number of stools, the number of vomiting per day, the mean value of maximum temperature, the mean value of hospitalization.
ACQUIRED DRUG RESISTANCE TO NRTI CLASS IN TREATMENT-EXPERIENCED HIV INFECTED PATIENTS FROM THE CONSTANTA COUNTY: THERAPEUTIC IMPLICATIONS
Authors:   Clinical Hospital of Infectious Diseases, Constanta, Cernat Roxana-Carmen , Dumitru Irina Magdalena ,   Clinical Hospital of Infectious Diseases, Constanta,   “Ovidius” University of Constanta, Otelea D. ,   “Prof. Dr. Matei Bals” National Institute of Infectious Diseases, Bucharest, Rugina Sorin ,   Clinical Hospital of Infectious Diseases, Constanta,   “Ovidius” University of Constanta
Published: August 2021

Objective. To determine the prevalence of acquired drug resistance (ADR) and of resistance patterns in treatment-experienced HIV infected patients from Constanta in order to establish the best therapeutic options in NRTI class. Material and methods. A retrospective study which included 144 treatment-experienced HIV patients with confirmed viral failure. The strains isolated from these patients were analysed in the Molecular Genetic Laboratory of „Matei Bals“ National Institute of Infectious Diseases, Bucharest and the resulting sequences were saved in FASTA format. The HIV-1 subtyping was based on „REGA HIV01&2 Automated subtyping tool version 2.0“ algorithm. „Stanford HIVdb Program version 8.4“ was used in order to determine the therapeutic options. For statistical calculations, the R-Project software was used. Graphic representations were performed using GNUPLOT program. Results. The prevalence of the acquired drug resistance was 92.36%. The most frequent mutation occurred at the level of the codon 184. The TAM-2 path was more frequently selected compared to TAM-1. Association between TAM1 and TAM 2 were also found, mutation K65R being rarely met. Conclusions. The prevalence of the acquired drug resistance in our study was high, The most valuable therapeutic option in the INRT class remains tenofovir, due to the mutational profile, which was selected on account of the extensive use of thymidine analogues.
HIV INFECTION AMONG ETHNOBOTANICALS IV DRUG USERS FOLLOWED IN „DR. VICTOR BABES” CLINICAL HOSPITAL FOR INFECTIONS AND TROPICAL DISEASES
Authors:   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest, Popa Ionut , Erscoiu Simona ,   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest,   “Carol Davila” University for Medicine and Pharmacy, Bucharest, Ianache Irina ,   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest, Burcos Olivia ,   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest, Radoi Roxana ,   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest, Oprea Cristiana ,   “Dr. Victor Babes” Clinical Hospital for Infections and Tropical Diseases, Bucharest,   “Carol Davila” University for Medicine and Pharmacy, Bucharest
Published: August 2021

HIV/HCV co-infection is permanently increasing in our country especially among intravenous drug users (IDUs) from low socio-economical risk categories. HIV/HCV co-infection among IDUs is associated with a complex pathology, including psychiatric disorders due to severe addiction syndrome, bacterial infection at the injection site and systemic bacterial infections of various degrees of severity. Due to HIV related immunosuppression, pulmonary or extra-pulmonary tuberculosis is frequently diagnosed, with major risk for dissemination Mycobacterium tuberculosis in the general population, including MDR or XDR TB strains.
INFECŢIA HIV LA CONSUMATORII DE DROGURI ETNOBOTANICE AFLAŢI ÎN EVIDENŢA SPITALULUI CLINIC DE BOLI INFECŢIOASE ŞI TROPICALE „DR. VICTOR BABEŞ“ DIN BUCUREŞTI
Authors:   Spitalul Clinic de Boli Infecţioase şi Tropicale „Dr. Victor Babeş“, Bucureşti, Popa Ionuţ , Ianache Irina ,   Spitalul Clinic de Boli Infecţioase şi Tropicale „Dr. Victor Babeş“, Bucureşti, Burcos Olivia ,   Spitalul Clinic de Boli Infecţioase şi Tropicale „Dr. Victor Babeş“, Bucureşti
Published: August 2021

Incidenţa coinfecţiei HIV/VHC este în creştere în ţara noastră, în special în rândul consumatorilor de droguri injectabile ce provin din medii sociale defavorizate sau din grupe vulnerabile aflate la risc. La aceşti pacienţi se descrie o patologie infecţioasă variată, care necesită deseori îngrijiri multidisciplinare (boli infecţioase, pneumoftiziologie, psihiatrie, cardiologie, chirurgie). Utilizatorii de droguri injectabile prezintă frecvent tulburări neuropsihice din cauza sindromului de adicţie şi au un risc crescut de a contacta infecţii virale (cu transmitere pe cale parenterala şi sexuală), infecţii bacteriene la poartă de intrare sau infecţii bacteriene sistemice severe. Pe fondul imunosupresiei progresive, secundare infecţiei HIV, pacienţii pot dezvolta tuberculoză pulmonară şi extrapulmonară, cu risc important de diseminare în populaţia generală, inclusiv a formelor cu tulpini de Mycobacterium tuberculosis multidrog rezistente (MDR) sau cu spectru de rezistenţă lărgit (XDR).
Graves’ ophtalmopathy and dysthyroid optic neuropathy: Imaging studies for diagnosis
Authors:   Emergency University Hospital, Bucharest, Romania, GRECESCU Mihai Leonard C. ,   "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

The diagnosis of Graves’ ophtalmopathy (GO) is based on clinical examination, laboratory tests (indicating thyroid dysfunction and inflammatory and autoimmune unbalance) and imaging studies (such computed tomography, magnetic resonance imaging, ultrasound and colour Doppler imaging). Imaging studies can be helpful in establishing the certain diagnosis of GO, because they provide objective morphological findings of the orbital structures. An important role of imaging studies is revealed in differential diagnosis versus other orbital diseases and can be also used to evaluate the progression of the disease and follow-up after clinical or surgical treatment.
Long COVID syndrome – general aspects
Authors:   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România, TICĂRĂU Adriana ,   Cabinet medical individual, Bucureşti, România, IANCU Mihaela Adela ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România,   Cabinet medical individual, Bucureşti, România, MATEI Dumitru ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, România,   Institutul Naţional pentru Sănătatea Mamei şi Copilului „Alessandrescu-Rusescu“, Bucureşti, România
Published: August 2021

2020), growing scientific evidence worldwide suggests that a small percentage of people who have developed COVID-19 and healed after the initial infection may experience a series of persistent symptoms over a period of more than 12 weeks, such as marked fatigue, shortness of breath, confusion, diarrhea, or other symptoms that cannot be explained by an alternative diagnosis. This status has been called “long COVID syndrome” or ”post COVID syndrome”.
Possibility of using embryonic neural cells to regenerate structures of the inner ear of Guinea pigs after experimental ototoxicosis
Authors:   “O.S. Kolomiychenko", SAPIZHAK Iryna Ihorivna ,   Institute of Otolaryngology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine, PYSANKO V. ,   “O.S. Kolomiychenko" Institute of Otolaryngology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine, MALYSHEVA T. ,   “Romodanov" Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine
Published: August 2021

Hearing disorders greatly impair the comfort of life, change a person's emotional state, and when developed in early childhood lead to disorders of psycho-social formation of personality. There are currently no effective treatments for patients with sensorineural hearing loss (SNHL). Therefore, all over the world prefer "substitution tactics", namely - hearing aids for deafness, or cochlear implant for deafness. Aim. To evaluate the influence of NEC in different ways of their introduction on the morphological state of the structures of the inner ear (Corti's organ and the first neuron, vascular strip), as well as the auditory nerve on the background of aminoglycoside ototoxicosis. To investigate the characteristics and directions of reorganization of hemoblood supply and features of cyto - and myeloarchitectonics of structures of the inner ear. Materials and methods. To study the effectiveness of neuronal embryonic cells (NEC) in aminoglycoside ototoxicosis, experimental studies were performed on 40 guinea pigs weighing from 500 to 600 g. SNHL was caused by the introduction of aminoglycoside antibiotic - gentamicin sulfate at a dose of 100 mg/kg for 14 days. The neuronal stem cell suspension was administered in a volume of 2 million cells in 0.5 ml intratympanically and 2 million cells in 0.5 ml suboccipitally on days 1 and 15 of the experiment. Results and discussion. The influence of NEC on different methods of their introduction on the morphological state of the structures of the inner ear (Corti's organ and the first neuron), as well as the auditory nerve on the background of aminoglycoside ototoxicosis was evaluated. The characteristics and directions of reorganization of hemoblood supply and features of cyto - and myeloarchitectonics of structures of an inner ear according to an estimation of neurovasal relations are investigated. Conclusions. The data obtained indicate that intratympanic and suboccipital administration of NEC promotes the regeneration of damaged cell structures of the inner ear. This opens the prospect of using NEC to develop new approaches in the treatment of patients with sensorineural hearing loss.
Pressurized intraperitoneal aerosol chemotherapy in nonresectable carcinomatosis from colorectal cancer
Authors:   Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, Bucharest, Romania, BACALBASA Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BALESCU Irina ,   Department of Surgery, Ponderas Academic Hospital, Bucharest, Romania, ALOUL Adnan Al ,   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania,   Doctoral School, “Titu Maiorescu“ University, Bucharest, Romania
Published: August 2021

Peritoneal carcinomatosis colorectal cancer unfortunately represents a frequently encountered condition during the natural history of this malignancy which has been considered for a long period of time as a terminal event. However, once new surgical and oncological therapies have been reported significant changes have been reported in the management of these cases. Therefore, cytoreductive surgery to no residual disease as a stand-alone procedure or in association with intraperitoneal hyperthermic chemotherapy has been proposed and significant benefits in terms of survival have been reported; unfortunately not all patients with peritoneal carcinomatosis are candidates for this combined approach, especially if extended, nonresectable lesions are present. In such cases pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been proposed with promising results. The aim of the current paper is to review the most important studies conducted on this issue.
In vitro evaluation of the cyto- and genotoxicity of titanium and titanium-based alloy Ti-6Al-4V used in the manufacture of screw type dental implants - preliminary study
Authors:   “Dunărea de Jos” University, Galați, Romania, MARCU Teodora , MIHAI Augustin ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BURLIBAȘA Mihai ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CONSTANTIN Nicoleta ,   Faculty of Biology, University of Bucharest, Romania, CRISTACHE Corina Marilena ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PERIEANU Viorel ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CHIRILĂ Mihaela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, PERIEANU Mădălina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, MALIȚA Mădălina ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, COSTEA Radu ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, COSTEA Raluca ,   Private practice, Brașov, Romania, BABIUC Iuliana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, TĂNASE Gabriela ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BEURAN Irina Adriana ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, DRĂGAN Constantin Florin ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, BURLIBAȘA Liliana ,   Faculty of Biology, University of Bucharest, Romania
Published: August 2021

Introduction. Titanium and the alloys that contain this element became in the last decade of the twentieth century almost irreplaceable materials in many biomedical fields, including dentistry. Purpose. The purpose of this study is to test and evaluate the cyto- and genotoxicity of Ti4 and Ti-6Al-4V, to obtain biomaterials with antimicrobial properties, compatible with the human body. Material and method. Ti4 and Ti-4Al-6V in powder form were analyzed using cell proliferation analysis and micronucleus test. Two concentrations of 1.5 mg/ml and 3 mg/ml were tested for each type of sample. Results and discussions. For both materials tested in the two concentrations, the presence of micronuclei was observed, but within normal limits. Conclusions. Although the variations are within normal limits, it should be noted that for Ti-6Al-4V the incidence was higher at both concentrations than in the case of Ti4.
Serum levels of some selenodependent proteins in thyroid disorders
Authors:   Faculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, CATIANIS Alexandra Gabriela , VIRGOLICI Bogdana ,   Faculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, TOTAN Alexandra ,   Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, VIRGOLICI Horia ,   Faculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, GREABU Maria ,   Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, MOHORA Maria ,   Faculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: August 2021

Introduction. The implications of oxidative stress and inflammation are unanimously accepted in thyroid disease. Objective. The aim of our study was to find correlations between serum antioxidant markers: glutathione peroxidase-3 (GPx-3), thioredoxin (Trx), total antioxidant capacity (TAC), inflammatory marker IL-8 and thyroid hormones, TSH and anti-thyroperoxidase antibodies (ATPO antibodies). Patients with different thyroid disorders were compared. Materials and methods. The study included 57 patients (men and women), divided into three groups: 26 patients with hyperthyroidism, 19 patients with hypothyroidism and 12 patients with autoimmune thyroiditis. The control group was represented by 33 healthy subjects. All the participants provided the informed consent for this study. Results. Our results showed that the patients with autoimmune thyroiditis had the highest level of Il-8 and the lowest TAC. Both Trx and GPx-3 were negatively correlated with TAC and IL-8 was positively correlated with the free T4 level, the ATPO antibodies titers, GPx-3 activity and negatively with serum TAC values. Conclusions. Systemic oxidative stress and inflammation are present in thyroid disorders, act in cluster and potentiate each other.The presence of autoimmune antibodies worsens the biological picture.
Post-resectional pelvic recurrences of rectal cancer
Authors:   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania, ALOUL Adnan Al ,   Doctoral School, “Titu Maiorescu“ University, Bucharest, Romania, UNGUREANU Dan Florin ,   Department of Surgery, “Titu Maiorescu“ University, Bucharest, Romania, BACALBASA Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Visceral Surgery, Center of Excellence in Translational Medicine “Fundeni” Clinical Institute, Bucharest, Romania
Published: August 2021

Introduction. Pelvic recurrence is not a rare event after resection with curative intent for rectal cancer originating from different segments of the rectum (lower, intermediary and superior part). Material and methods. This retrospective observational study included 106 patients; among these cases there were 79 patients who accepted surgical treatment of rectal cancer (treated in a governmental hospital between 2014 and 2017) and who were submitted to anterior resection with Hartmann’s procedure (6.5% of patients), anterior resection of rectosigmoid with colorectal anastomosis (78% of cases) and abdominoperineal resection (15% of cases). Results. After a 2 year follow-up, pelvic recurrence was reported in 11patients ~ 14% of cases: 33% rate of recurrence after Hartmann procedure, 9% rate of recurrence after abdominoperineal resection, and 10% rate of recurrence after anterior resection of rectosigmoid with colorectal anastomosis. 39 patients (49% of cases) had been submitted to preoperative radiotherapy: the pelvic recurrence rate among these cases was of 11% (9 patients). The rate of recurrence (RR) was also significantly influenced by the stage at diagnostic: stage III had RR = 52% of cases, stage II had RR = 41% of cases and stage I had RR = 0% of cases). The survival rate among surgically treated patients after 1 one year was 86%, and 80% in the first 2 years after treatment. Conclusions. Rectal cancer diagnosed in advanced stages has a high recurrence rate. A low recurrence rate indicates successful curative surgical treatment. The highest recurrence rate was reported after Hartmann procedure (which was usually performed as an emergency operation for locally advanced lesions).