bluuebunny/crossref_metadata_2025 huggingface dataset:
Hogyan változott az akut myeloid leukaemiás betegek túlélése a terápiás lehetőségek bővülésével az elmúlt 10 évben klinikánkon?
Authors: Gaál Lilla , Ruff Eszter , Wiedemann Ádám , Svorenj Szabolcs , Szita Virág Réka , Tóth András Dávid , Masszi András , Horváth Laura , Szombath Gergely , Nagy Zsolt , Várkonyi Judit , Benedek† Szabolcs , Farkas Péter , Bödör Csaba , Masszi Tamás , Varga Gergely
Published: November 2023

Bevezetés: Az akut myeloid leukaemia (AML) nagy mortalitású
hematológiai malignitás, amelynek kezelése különösen a betegek többségét alkotó
65 év feletti korcsoportban nagy kihívás. Míg korábban az intenzív indukciós
terápiára nem alkalmas betegek számára csupán palliatív cytoreductio és
szupportív ellátás jöhetett szóba, 2018-tól új kezelési lehetőségként az
azacitidin–venetoklax-kombináció is megjelent. Klinikai vizsgálatokban ez a
kezelés jelentős túlélési előnnyel járt, arról azonban, hogy mennyire
befolyásolta a mindennapi klinikai gyakorlatot és a teljes betegpopuláció
túlélését, kevés adat áll rendelkezésre. Célkitűzés: Azt
szerettük volna megvizsgálni, hogy az azacitidin–venetoklax-kombináció
elérhetősége hogyan változtatta meg az AML kezelését és a betegek túlélését
klinikánkon. Módszer: Kutatásunkban retrospektíven vizsgáltuk
minden, 2011. január 1. és 2021. december 31. között a III. Sz. Belgyógyászati
(2020 óta Belgyógyászati és Hematológiai) Klinikán AML-lel diagnosztizált beteg
túlélési adatait a kapott kezelés és a kezelési időszak (2011–2017 vagy
2018–2021) függvényében. A kutatásból kizártuk a promyelocytás leukaemiával
diagnosztizált betegeket. Eredmények: A vizsgált időszakban
összesen 423 AML-beteget diagnosztizáltunk. Az esetszámok jelentősen nőttek: míg
az első 7 évben 184 beteget kezeltünk, addig a második időszak csupán 4 éve
alatt már 239-et. A betegek medián életkora 67,6 év, több mint 60%-uk 65 év
feletti volt. A teljes várható túlélés javuló trendet mutatott: 2011 és 2017
között 4,8 ± 0,9 hónap, míg 2018 és 2021 között 8,3 ± 1,4 hónap volt (p =
0,051). Szignifikánsan javult a teljes túlélés a 65 év feletti betegek esetén:
3,1 ± 0,5 és 4,9 ± 0,6 hónap (p = 0,01). A javulás hátterében elsősorban az
állhat, hogy a 65 év feletti, korábban csak szupportívan kezelt betegek jelentős
részét tudtuk aktívan kezelni azacitidin–venetoklax-kombinációval: az aktívan
kezelt betegek aránya a második időszakban 57,1%-ról 75,3%-ra nőtt.
Következtetés: A 65 év feletti, kuratív terápiára nem
alkalmas betegek túlélése fokozatos javulást mutatott, amihez valószínűleg
nagyban hozzájárult az újabb terápiás alternatívák klinikai gyakorlatban történő
elterjedése. Orv Hetil. 2023; 164(45): 1787–1794.
Stand-Alone Conclusion Section in Open-Access Research Articles: Organizational Structure
Authors: Kanoksilapatham Budsaba
Published: November 2023

Background: Research articles (RAs) have been highlighted as one of the most essential channels for academicians to disseminate knowledge. Typically, RAs consist of a nomenclature of the four sections of introduction, methods, results, and discussion, commonly known as IMRD, with each section governed by an organizational structure determined by genre analysis. However, due to the increasing prevalence of the stand-alone conclusion section in recent years and the expansion of open-access journals, understanding how this conclusion section is constructed can benefit scholars in an academic endeavor.
Methods: This study aims to identify the organizational structure of the stand-alone conclusion section in open-access journals. An original dataset of 55 open-access journal RAs from four major academic disciplines honored as “Articles of the Year 2021” was analyzed. Only the RAs with stand-alone conclusions within a calculated word range were selected, yielding a final dataset of 25 comparable conclusion sections. Then, anchored on genre analysis, the compiled dataset was analyzed quantitively and qualitatively.
Results: Based on the genre analysis conducted, a set of three moves and their pertaining steps were identified, forming various organizational patterns but one compelling one. Furthermore, the full-fledged two-layer rhetorical structure of the section depicting the frequencies of occurrence of individual moves and steps is quite revealing, highlighting the crucial significance of restating the findings generated from the study being reported. The results demonstrate not only how established this section is but also how it is currently structured, performing its critical function of concluding RAs.
Conclusion: This study has provided insights into integrating analytical elements to successfully stage persuasive arguments in the conclusion section, a skill that needs to be inculcated in novice or early-career researchers and seasoned researchers alike.
The Learning Potential of a TV Series in Promoting L2 Incidental Learning of Idiomatic and Non-Idiomatic Phrasal Verbs
Authors: Alshumrani Hassan
Published: November 2023

Background: The bulk of past studies, which have shown that audiovisual materials are potential sources for phrasal verb learning, have focused on short materials. However, the incidental learning of idiomatic and non-idiomatic phrasal verbs through extensive viewing of a complete season of a TV series has remained underexplored.  
Purpose: The main aim of the present study is to explore the learning potential of viewing an entire season of a TV series in incidental learning of idiomatic and non-idiomatic phrasal verbs.
Method: The study recruited 75 second language (L2) learners and placed them randomly into an experimental group and a control group. Data were gathered through the updated vocabulary levels test and two vocabulary tests. Over one month, the experimental group viewed an entire season of a TV series, and the control group followed their regular learning routine. Immediately after the end of the eight viewing sessions, the experimental and control groups completed the form and meaning post-tests.
Results: The results indicated that viewing a TV series contributed to the development of phrasal verb knowledge. The experimental group developed both form and meaning knowledge of the target phrasal verbs, and greater gains were made at the form recognition level. The research also revealed that although repetition of the target phrasal verbs in the series significantly correlated with the learning gains reported from both the form and meaning tests, its role in meaning was greater.
Implications: The study provides further valuable insights into how watching a TV series affects the learning of idiomatic and non-idiomatic phrasal verbs. It also advances our understanding of how repetition impacts phrasal verb uptake.
Building Scientific Knowledge in English: Integrating Content, Cognition and Communication in Secondary School CLIL Biology
Authors: Gerns Pilar
Published: November 2023

Background: The focus of this paper is on Dalton-Puffer’s construct of the Cognitive Discourse Function (cdf) (2013), which offers clil teachers a practical framework through which they can more easily understand the complex idea of integrating the content, cognition, and language required for their subject. These functions have mainly been addressed from classroom observations or task prompts, and little is known about their teachability and effectiveness on students’ content knowledge.

Purpose: This paper explores whether the cdf of ‘comparing’ (a subcategory of ‘classify’) can be taught to Spanish seventh-grade clil biology students (N = 37) and examines the effect of teaching it explicitly on their written performance.

Method: An operational framework was developed to define this cdf and an exploratory study was performed in which students were asked to hand in written comparisons. Quantitative and qualitative pre-and post-tests were applied.

Results: Significant results were obtained for the experimental groups, which improved in both content and language learning, scoring higher on inclusion of content points, justification of their scientific claims, concept formation and use of lexico-grammatical forms.

Conclusion: These findings add to our understanding of the importance of integrating cognition and language in teaching and learning natural sciences, within which CDFs can be a useful starting point.
ChatGPT: Where Is a Silver Lining? Exploring the realm of GPT and large language models
Authors: Tikhonova Elena , Raitskaya Lilia
Published: November 2023

Introduction: the JLE editors analyse the scope and depth of the subject area of ChatGPT and related topics based on the Scopus database. The Scopus statistics prove a skyrocketing rise in the number of publications in the field in question during 2023. The major alarming themes cover authorship and integrity related to AI-assisted writing, threats to educational practices, medicine, and malevolent uses of ChatGPT.
Keywords Explained: the key terminology is defined, including generative pre-trained transformers (GPT); ChatGPT; artificial intelligence (AI); AI chatbots; natural language processing (NLP); large language models; Open AI; large language model (LLM).
International Research on ChatGPT: as of September 24 2023, the Scopus database has indexed 1,935 publications, with “ChatGPT” in the title, abstract, or keywords. A skyrocketing rise in the number of research has been reported since the early days of 2023. 1,925 indexed publications out of 1,935 were published in 2023. Most of them came from the USA, India, the UK, and China. The number of documents indexed in the Scopus database as well as PubMed,  arXiv and others are exponentially rising.
ChatGPT in Education: the academic community has been actively discussing the challenges education will face in the era of ChatGPT in the context of the fundamental threats posed to the educational system. The latter include assessment procedures, information accuracy, and skill devaluation. As many complex technologies, generative pre-trained transformers are ambivalent in nature, providing a great potential for learning and education at large, including new approaches based on critical thinking and awareness of the pros and cons of AI.
ChatGPT in Science: great prospects for text generation and improvements in language quality adjoin to dubious authorship and potentially inconsistent and erroneous parts in the AI-produced texts. Publishers and journals are working out new publishing policies, including publishing ethics towards AI-assisted or AI-improved submissions.
Conclusion: JLE is planning to revise its editorial policy to address the new challenges from AI technologies. JLE editors welcome new submissions of research articles and reviews as well as special issues on ChatGPT and related themes, with potential applications of chatbots in education, innovative approaches to writing assignments, facilitating personalized learning, academic integrity issues related to AI-supported writing, etc. in focus.
Proteome analysis v1
Authors: A Parra-Rivas Leonardo
Published: November 2023

Proteome analysis
In vitro phosphorylation v1
Authors: A Parra-Rivas Leonardo
Published: November 2023

In vitro phosphorylation
Proximity Ligation Assay (PLA) v1
Authors: A Parra-Rivas Leonardo
Published: November 2023

Proximity Ligation Assay (PLA)
Pull-down Assays v1
Authors: A Parra-Rivas Leonardo
Published: November 2023

Pull-down Assays
Dynamic response estimation of an equivalent single degree of freedom system using artificial neural network and nonlinear static procedure
Authors:   Laboratoire des Travaux publics, ingénierie de Transport, environnement, Ecole Nationale Supérieure des Travaux Publics (ENSTP), Kouba, Algiers, Algeria, Abdellatif Benbokhari , Benazouz Chikh ,   University Gustave Eiffel, UPEC, CNRS, Laboratoire Modélisation et Simulation Multi Echelle (MSME 8208 UMR), Marne-la-Vallée, France, Ahmed Mébarki ,   Permanent Guest Professor within “High-Level Foreign Talents Programme” Grant, Nanjing Tech University, China
Published: November 2023

This paper introduces an innovative methodology for predicting the maximum dynamic response of structures using capacity curves and artificial neural networks (ANNs). This novel approach offers a quick and accurate procedure for estimating target displacements, obviating the need for intricate supplementary computations. The method generates a comprehensive dataset encompassing the bilinear representation of a single-degree-of-freedom (SDOF) characteristic, with ground motion parameters as inputs and maximum inelastic displacement as the corresponding output. This dataset is used to train an ANN model, with meticulous calibration of hyperparameters to ensure optimal model performance and predictive precision. The findings of this study demonstrate that the ANN model showed operational efficacy in approximating dynamic displacements. It is notably revealed that the size of the dataset significantly influences the ANN's performance and predictive accuracy. Through comparative analysis with established methodologies such as the displacement coefficient method and the modified coefficient method adopted by the Federal Emergency Management Agency (FEMA), the ANN model emerges as a fast tool for precisely predicting the dynamic response of single-degree-of-freedom systems, particularly those characterized by vibration periods exceeding 0.5 seconds. Consequently, this research culminates in the assertion that the ANN, owing to its inherent simplicity and impressive precision, is an alternative tool for estimating target displacements.
Evaluation of strength of self-compacting concrete having dolomite powder as partial replacement for cement
Authors:   Civil and Structural Engineering, Annamalai University, Chidambaram, Tamil Nadu, India, Kumar R. Vaishnava , Prabaghar A. ,   Civil and Structural Engineering, Annamalai University, Chidambaram, Tamil Nadu, India
Published: November 2023

Now a day, the utilization of self-compacting concrete (SCC) has become popular in creating RC structures. Apart from self-compaction, SCC has got many advantages such as excellent flow ability, filling ability, smooth finish of surface, ease of work etc. The use of waste material in concrete is the area of having scope for researchers for many years. Use of waste material reduces the consumption of cement by construction sector. In this present experimental work, dolomite powder is used as fractional replacement material for cement. The cement in the SCC is replaced by dolomite at fractions of 10%, 20%, 30%, 40%, 50%, 60%, and 70%. Fly ash is also added to the mix at constant fraction of 18% of the cement. The strength of SCC is assessed by performing compression test, splitting tension test and bending test. The test results showed that the use of dolomite powder in SCC is advantageous up to 20% replacement fraction. It is also observed that the strength of DC40 mix (i.e the mix having Dolomite at 40% of cement) is almost equal to the strength of normal SCC. Even at 70% replacement level, the strength of SCC having dolomite achieved is 25 MPa. SEM images are analyzed to identify the spread of hydrated products.
Prevenção de Lesões por Pressão em Neonatos na UTI Neonatal: Um Protocolo de Revisão de Escopo
Authors: Lima Suzinara Beatriz Soares de , Viero Cibelle Mello , Costa Valdecir Zavarese da , Cabral Thaynan Silveira , Fonseca Eliana Rosa da
Published: November 2023

Objetivo: Mapear as estratégias para a prevenção de lesões por pressão em neonatos internados em unidades de terapia intensiva neonatal. Método: O presente estudo utiliza um protocolo de revisão de escopo desenvolvido pelo método JBI. O objetivo é responder à seguinte pergunta: Quais são as estratégias para prevenção de lesões por pressão em neonatos internados na Unidade de Terapia Intensiva Neonatal? Serão consultadas as seguintes bases de dados: MEDLINE (PubMed), Scientific Electronic Library Online (SciELO), SCOPUS (Elsevier) e EMBASE (Elsevier), LILACS, BDENF e outras (via Portal Regional da BVS), Cochrane Library (Wiley), Web of Science Core Collection (Clarivate Analytics), Academic Search Premier (Ebsco), CINAHL with Full Text (Ebsco), Pubmed Central (NLM) e literatura cinzenta. A seleção e extração dos dados serão realizadas por revisores independentes. Os resultados serão apresentados graficamente com um resumo narrativo. O software Endnote será utilizado para gerenciar as referências, enquanto o software Rayyan Systems Inc. será empregado para a seleção. Instrumentos foram elaborados para auxiliar nas etapas de seleção e extração de dados. Os resultados serão apresentados por meio do fluxograma PRISMA-ScR.
Construção e avaliação de um guia técnico para gestão de casos de sífilis: estudo metodológico
Authors: Dorneles Fernanda Vaz , Silva Mariana Xavier da , Oliveira Amanda Curtinaz de , Silva Guilherme Machado , Behrends Daniela Barbosa , Paz Adriana Aparecida
Published: November 2023

Objetivo: elaborar e avaliar um guia técnico como recurso instrucional e didático para auxiliar profissionais de saúde na gestão de casos de sífilis adquirida e sífilis gestacional. Método: estudo metodológico, com abordagem quantitativa, que elaborou o guia técnico e submeteu à avaliação de um Comitê de Especialistas. As respostas foram analisadas pela concordância dos critérios de no mínimo 80% e estatística descritiva. Resultados: O “Guia Técnico para Gestão de Casos de Sífilis Adquirida e Sífilis Gestacional” foi elaborado no editor Power Point, contendo 150 páginas, disponibilizado como Portable Document Format (PDF). Ele foi estruturado em seções que incluem a abordagem da identificação, assistência, notificação e monitoramento da sífilis adquirida e gestacional, além de conter dois casos clínicos fictícios para praticar o conhecimento. O Comitê de Especialistas foi composto por 5 (83,3%) enfermeiros e 1 (16,7%) médico, todos atuando no Rio Grande do Sul, prevalecendo o sexo feminino 5 (83,3%), a idade média de 45,83±7,22 anos e a mediana de 7,3(3,8-17) anos de trabalho. A concordância foi plena (100%) em todos os critérios avaliados. Conclusão: o guia revelou-se um importante recurso instrucional e didático para consulta rápida e objetiva dos profissionais de saúde.
Diagnósticos de enfermagem em puérperas fundamentados na teoria da consecução do papel materno: estudo transversal
Authors: Jesus Cristine Alves Costa de , Santos Simone Silva dos
Published: November 2023

Objetivo: conhecer o perfil diagnóstico de enfermagem de mulheres no pós-parto, internadas no Alojamento Conjunto, embasado na Taxonomia II da NANDA-I e na Teoria da Consecução do papel materno. Método: estudo descritivo, transversal, com abordagem quantitativa, realizado com 72 puérperas. Utilizou-se um instrumento semiestruturado para coleta de dados, contendo informações sociodemográficas, anamnese e exame físico. Os diagnósticos de enfermagem foram elencados a partir da NANDA-I. Para análise dos dados, adotou-se estatística descritiva, com frequências relativas e absolutas. Resultados: foram arrolados 638 diagnósticos de enfermagem, sendo 49 diferentes e quatro prevalentes em mais da metade das puérperas: Integridade tissular prejudicada, Dor aguda, Distúrbio no padrão de sono e Conhecimento deficiente. Conclusão: a caracterização do perfil diagnóstico das puérperas permite o conhecimento das reais necessidades de cuidado e possibilita uma assistência mais integral abrangendo todas as nuances envolvidas na consecução do papel materno.
Organização do trabalho e burnout entre profissionais de enfermagem na pandemia: estudo de método misto
Authors: Barbosa Amanda da Silveira , Prates Cassiana Gil , Campos João Lucas de Oliveira , Pai Daiane Dal , Magalhães Ana Maria Muller de
Published: November 2023

Objetivo: avaliar as repercussões da pandemia de COVID-19 na organização do trabalho e no Burnout dos profissionais de enfermagem em um hospital da região sul do Brasil. Método: desenho misto explanatório sequencial, em cinco unidades de internação adulta, realizado de agosto a novembro de 2020. Na etapa quantitativa, numa amostra de 78 participantes, foi aplicado o Inventário de Burnout de Maslach e os dados foram analisados por meio de estatística descritiva e analítica. Na etapa qualitativa, foram realizadas entrevistas semiestruturadas online, por amostragem intencional, com nove profissionais, e os dados foram submetidos à análise de conteúdo categorial temática. Resultados: noventa e nove porcento dos profissionais atenderam pacientes suspeitos ou confirmados com a doença; 64% afastaram-se por suspeita e 35% por confirmação de COVID-19; 11,5% apresentaram a Síndrome de Burnout. O medo, o compromisso com o trabalho, as falhas nos protocolos e na comunicação institucional foram temas das categorias. Conclusão: apesar de a Síndrome de Burnout ter apresentado baixa frequência entre os trabalhadores de enfermagem, constatou-se que a pandemia de COVID-19 repercutiu sobremaneira na organização do trabalho desses profissionais.
Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review
Authors: Igissin Nurbek , Zatonskikh Vera , Telmanova Zhansaya , Tulebaev Rais , Moore Malcolm
Published: November 2023

Laryngeal cancer comprises 30%-40% of head and neck malignancies, and it is the most common malignancy in otolaryngology. The main risk factors for laryngeal cancer are tobacco use, excessive alcohol consumption, gastroesophageal reflex, Plummer-Vinson syndrome, exposure to heat, chemicals, and some viral infections. This literature review summarizes all known data over the past decade with an assessment of the main etiological factors related to cancer incidence, general measurement issues in the cancer epidemiology and the current state of science in relation to laryngeal cancer. The geographical distribution of laryngeal cancer also reveals some important aspects. Europe remains the most prevalent continent for this type of malignancy, whilst the epidemiologic burden in Africa remains low. Overall, there are clear differences in morbidity and mortality from laryngeal cancer between urban and rural areas, with gender inequalities. In some countries, the incidence rates are high in rural areas, and in some, such as in China, the urban population is more affected. High rates of laryngeal cancer are closely associated with both low average income and a high percentage of the population with lower-than-average education countries with higher Socio-demographic Index (SDI) have made greater improvements in the treatment of LC than countries with lower SDI. Epidemiological data on risk factors can provide valuable information for developing cancer prevention strategies.
Trends in the Antibiotic Resistance of Non-Tuberculous Mycobacteria in Iran: A Systematic Review and Meta-Analysis
Authors: Heidari Hamid , Kalantari Parisa , Sholeh Mohammad , Pour Sahel Hamze , Darbandi Atieh , Maleki Abbas , Ghaysouri Abbas , Kazemian Hossein
Published: November 2023

Background: Non-tuberculous mycobacteria (NTM) infections have been continuously increasing as major concerns of public health in Iran. Because innate resistance of NTM species, the treatment of these infections is difficult task, but until now resistance pattern of NTM and suitable regimens are not determined.
Methods: We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until Dec 2022). All statistical analyses were carried out using the statistical package R.
Results: Eleven studies included in the analysis were performed in 6 provinces and investigated 1223 NTM clinical species. The majority of the studies originated in Tehran. Among the first-line anti-TB drugs, almost all NTM species were highly resistant to first-line anti-TB drugs. No significant difference in the isoniazid resistance rate was found in the slow or rapid-growing species and Runyon's classification of NTM isolates. A decreased in the prevalence of ciprofloxacin, clarithromycin, and moxifloxacin resistance were showed in during 2013-2022 years.
Conclusion: Most investigated antibiotics have a minor effect on NTM species and a steady increase of resistance has been seen in last few years then, need more-effective alternative regimens is clear
Factors Related to Suicidal Ideation in Adolescents According to Types of Stress
Authors: Kwon Myoungjin , Kim Sun Ae , Lee Yun Ju
Published: November 2023

Background: We aimed to identify the factors associated with suicidal ideation by classifying adolescents into three groups: no stress, interpersonal stress, as well as academic and career stress.
Method: Using the data from the 16th Korea Youth Risk Behavior Web-Based Survey (2020), 15,343 adolescents were included in the study, and their socio-demographic characteristics as well as physical and psychological factors were assessed. A complex sample logistic regression was performed to identify factors associated with suicide.
Results: The following factors were significantly associated with suicide: fatigue recovery by sleep, body mass index, physical activity, and depression in the no stress group; current school, academic grade, drinking, depression, loneliness, and anxiety in the interpersonal stress group; and gender, current school, academic grade, father’s educational level, drinking, fatigue recovery by sleep, depression, loneliness, subjective health, smartphone overdependence, as well as anxiety in the academic and career stress group (P < 0.05).
Conclusion: To prevent suicide among adolescents, it is necessary to consider these factors when developing educational policies.
Lncrna FGFR3-AS1 Is a Prognostic Indicator for Ovarian Cancer and Induces Cell Proliferation and Hinders Apoptosis
Authors: Zhang Yuyang , Sun Lili , Chen Tieshuang , Yue Yuanyuan , Zhao Lin , Zhang Dan
Published: November 2023

Background: Ovarian cancer is one of the most common malignant tumors in Gynecology, whose treatment was seriously limited by the unclear understanding of molecular mechanism in disease development. LncRNA FGFR3-AS1 is involved in human cancers. In this study, we aimed to clarify its regulatory effect on ovarian cancer.
Methods: Ovarian cell model was used in 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazoliumbromide (MTT) assay and flow cytometry for investigating the role of LncRNA FGFR3-AS1 in ovarian cancer. Western blot detection (CCND1、CDK6、MAPK9 and PIK3CA) tumor regulatory proteins. The study was conducted between March 2020 and October 2022 at General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, China.
Results: The results demonstrated the upregulation of LncRNA FGFR3-AS1 in ovarian cancer, whose expression was positively related to tumor grade and AJCC stage, and negatively correlated with patients’ prognosis. LncRNA FGFR3-AS1 promoted ovarian cancer development through promoting cell growth and inhibiting cell apoptosis. PI3K signaling pathway-related proteins may be implicated in the LncRNA FGFR3-AS1 induced regulation of ovarian cancer.
Conclusion: LncRNA FGFR3-AS1 was involved in the development of ovarian cancer, which has the potential to become therapeutic target and prognostic indicator in ovarian cancer treatment.
Identification of TMEM178 as a Potential Prognostic Biomarker and Therapeutic Target for Breast Cancer
Authors: Yan Jiaoyan , Yang Ye , Lu Jingrun , Yuan Yan , Wu Xiangyi , Huang Jian , Zhang Shu
Published: November 2023

Background: The transmembrane protein (TMEM) family plays important roles in cancer. However, the expression pattern and biological roles of TMEM178, a member of TMEM family, remains unclear in breast cancer (BRCA).
Methods: Methylation and RNA-seq data were obtained to explore methylation level. Expression of TMEM178, methylation inhibitor 5-Aza-CdR was used to verify the effect of methylation status on the expression of TMEM178. We comprehensively investigated the prognostic outcomes, biological functions and effects on immune cell infiltration of the TMEM178 in BRCA using multiple bioinformatics methods.
Results: The expression of TMEM178 was downregulated and negatively correlated with the level of DNA methylation and DNA methyltransferase (DNMT1, DNMT3A, and DNMT3B) in BRCA. Consistently, TMEM178 mRNA were confirmed to be downregulated, while upregulated in response to treatment with methylation inhibitor 5-Aza-CdR by RT-qPCR. Patients with high expression of TMEM178 have better prognosis and are more sensitive to targeted drug Pazopanib. Immune infiltration analysis showed that the infiltration levels of CD4+ T cell subsets were reduced in BRAC tissues with high TMEM178 expression, and immunosuppressive molecules of T-cell exhaustion were lower expression level.
Conclusion: Hypermethylation of the TMEM178 promoter region was a contributing factor to the downregulation of its expression, and TMEM178 may reflect a prognostic and immunosuppressive situation in BRCA.
Development of a Green Single Drop Microextraction Based on Deep Eutectic Solvent and HPLC-UV for Trace Residue Analysis of Three Frequent-Used Pesticides
Authors: Pourhossein Mehran , Khadem Monireh , Omidi Fariborz , Heravizadeh Omid Reza , Shahtaheri Seyed Jamaleddin
Published: November 2023

Background: A green sample preparation method named deep eutectic solvent-based single drop microextraction (DES-SDME) was developed and optimized for determining trace metribuzin, dichlorvos, and fenthion.
Methods: Two hundred seventy experimental runs were performed, and the optimal values of the five influential factors in the DES-SDME method were determined. The design of the study was based on one factor at a time and the peak area of high-performance liquid chromatography was used as a benchmark for comparing analysis results.
Results: After optimizing the effective factors, the linearity range, detection limit and quantification limit of the method were determined by drawing calibration curves for the studied analytes.
Conclusion: The results indicated the success of the developed method in obtaining acceptable figures of merit as a green preparation method with accuracy and precision.
Cross-Cultural Comparison of Fundamental Movement Skills of Children of Iranian Ethnicities
Authors: Tahmasebi Farshid , Hatami Farzaneh , Mohammadi Majid , Ahmadi Giti
Published: November 2023

Background: Cross-cultural studies can provide information on how different cultural contexts, lifestyles, and physical activity play a role in the development of motor skills. We aimed at a cross-cultural comparison of fundamental movement skills of children of Iranian ethnicities.
Methods: The statistical population included boys and girls aged 7 to 9 years from the centers of Tehran (Persian), Lorestan (Lor), Khuzestan (Arab) and Kurdistan (Kurdish) provinces in 2021 year. Overall, 240 people (60 from each province) participated in this research as a sample. Ulric Gross Motor development test (2000) was used to measure the Fundamental Movement skills.
Results: Results of multivariate analysis of variance showed that the main effect of culture (ethnicity) and interaction of culture and gender on Loco motor and object control skills were significant (P=0/001). In the total score of fundamental movement skills, the results showed that boys children scored significantly higher than girls (P=0/001). Moreover, Lor and Kurdish children significantly performed better than Fars and Arab children (P=0/001), but no significant difference was observed between the other ethnicities (P=0/452).
Conclusion: Differences in the levels of fundamental movement skills of children of different ethnicities may be due to different physical and cultural activities, attitudes, and motor habits.
Pregnancy in Wartime: An Opportunity for Making Peace through Health
Authors: Zahedroozegar Mohammad Hassan , Shaygani Fatemeh , Marzaleh Milad Ahmadi
Published: November 2023

The Article Abstract is not available.
Selenium Supplementation in Psoriasis Patients
Authors: Gerami Hadis , Khorasanian Atie Sadat , Lesani Azadeh
Published: November 2023

The Article Abstract is not available.
Impact of Caffeine Consumption on Sleeping Hours and Stress Scale among Anesthesiologists: A Cross-Sectional Study
Authors: Khamis Ahmed Mohamed , Mostafa Raham Hasan , Eldin Waleed Salah , Saleh Ashraf Nabil
Published: November 2023

Background: Due to its stimulatory effects, caffeine is one of the most frequently consumed mood and behavior altering beverages. It is commonly used to improve alertness in cases of fatigue after prolonged work. Health authorities recommend not to exceed a daily intake of <200 mg/day. The purpose of this study is to measure the prevalence of unsafe caffeine daily consumption (>200 mg/day), detect caffeine withdrawal and intoxication symptoms, and investigate the relationship between caffeine intake and stress and sleeping hours.
Methods: 168 anesthesiologists answered a questionnaire during the period of April to July 2022. After estimating daily consumption of caffeine, anesthesiologists were classified into either safe level group (daily consumption ≤ 200 mg/day), or unsafe level group (daily consumption >200 mg/day); then, further analysis was done.
Results: Almost 80% of the total participants were unsafe consumers. Junior doctors and registrars (group J) had a statistically higher caffeine consumption than consultants (group S) (433.9±228.7 mg versus 363.6±244.5 mg, respectively; P=0.017). Additionally, 45% of group J experienced intoxication symptoms, and 54% experienced withdrawal symptoms. These symptoms had a significantly higher prevalence in group J compared to group S (P=0.001 and P=0.004, respectively). Finally, no significant correlation was found between average daily caffeine consumption and daily sleeping hours and stress scale score (P=0.831 and P=0.324, respectively).
Conclusion: The consumption of caffeine-containing drinks among anesthesiologists was very high. Junior anesthesiologists specifically reported higher caffeine consumption, more intoxication and withdrawal symptoms, and a higher stress score than consultants.
Evaluating Determinants of Food Hygiene Behavior Based on Health Belief Model in Health Workers of Urmia Health Center
Authors: Zamaniahari Sahar , Zareipour MoradAli , Rezaei Zhila Mohammad , Saeed Jadgal Mohammad , Rostampor Fatemeh , Soltani Roya Gasem
Published: November 2023

Background: Observance of food hygiene is considered an important principle to prevent humans from contracting diseases and also to protect the environment from contamination. Health workers are on the front line forces of the health system. Therefore, promoting the health of health workers has an important role in promoting community health. The aim of this study is to investigate the determinants of food hygiene based on the Health Belief Model (HBM) in health workers in Urmia. Methods: In this descriptive-analytical study, 300 health workers in rural health centers of Urmia city were selected and entered into the study by census method based on inclusion criteria. Data collection tools included 3 parts: demographic characteristics, knowledge questionnaire, attitude and behavior, and health belief model questionnaire. Data were collected and analyzed using interviews. Results: The mean age of the workers was 36.76±7.61 year. The attitude and behavior of observing food hygiene had a statistically significant relationship with work experience, knowledge, attitude, gender, marital status, and level of education (P<0.05). Based on linear regression test, in all studied constructs, 30% of the variance of food hygiene behavior was explained. The predictive power of perceived efficiency was higher than other constructs (β=0.45). Conclusion: In designing educational interventions, the variables of self-efficacy, perceived benefits, perceived susceptibility, and perceived sensitivity should be emphasized as the most important predictors of food hygiene behaviors in health workers.
The Reliability and Validity of Persian Version of Sports Coaches' Nutrition Questionnaire
Authors: Ebrahimi Mohsen , Ahmadi Faezeh , Hashemifard Elahe Sadat , Mehri Nima
Published: November 2023

Background: Sports nutrition knowledge is one of the essential needs of coaches. However, there is no standardized questionnaire in Persian to assess coaches' nutritional knowledge and information. Therefore, the purpose of this study is to evaluate the validity and reliability of Persian version of the Coach Sports Nutrition Questionnaire (CSNQ). Methods: CSNQ was translated-re-translated according to the WHO standard method, following Iranian culture and eating habits. The reliability of the questionnaire was assessed by test-retest method, correlation coefficient and internal reliability by Cronbach's alpha, and differential validity by independent t-test. 123 Iranian coaches completed the questionnaire. Results: The total internal reliability of the questionnaire assessed by Cronbach's alpha was 0.73. The intragroup correlation of the questionnaire, assessed by the test-retest method, was 0.71. Moreover, the comparison of the coaches with different levels of education was found to be significant (P < 0.001). Conclusion: The Persian version of the questionnaire regarding the coaches' nutrition sports knowledge has acceptable reliability and validity. It can help other studies and evaluate sports nutrition knowledge in Persian coaches.
Investigation of the wing model dynamic stability in the airflow
Authors: Naumov A.M.
Published: November 2023

Investigating the aircraft structure elements for compliance with dynamic stability is one of the most important ways to study their dynamic properties. The paper considers possibility of the wing model dynamic loss of stability (flutter type) in the form of a flat rod of variable geometry close to the real wing geometry in the airflow. Internal force factors manifested under the frontal aerodynamic force influence, as well as increment in the lift and aerodynamic moment arising during possible small model oscillations are taken into account from the oncoming airflow side. Due to these external forces increment, the so-called energy pumping from the airflow side occurs, and the problem becomes non-conservative. Behavior of the first three complex eigenvalues of small oscillations was numerically studied, and the critical flow velocities, at which the model could lose dynamic stability, were determined for various parameters of the external aerodynamic forces.
Current effect parameters influence on radial dispersion of the metallic shaped-charge jets
Authors: Fedorov S.V. , Bolotina I.A. , Gorelov V.I.
Published: November 2023

To reduce penetration effect of a shaped charge, powerful current effect on the shaped charge jet could be introduced. Based on numerical simulation within the framework of a model of the uniformly elongating cylindrical rod, the paper analyzes features of the metal shaped-charge jets stretching, when passing a powerful electric current pulse through them. Main attention is paid to the effect of jet material radial dispersion behind its exit from the interelectrode gap. The role of magnetic energy stored in the jet elements during exposure was clarified in this phenomenon. For the shaped-charge jet middle sections formed by charges with diameter of 50 to 150 mm, distributions along the jet radius of the material density and the material radial velocity were obtained immediately after the current “cutoff”. They indicated that as a result of current exposure, the jet material surface layer could be torn off and dissipated with maintaining continuity of its central part. With an increase in strength of the current passed through the jet, thickness of its destroyed layer acquiring radial velocity directed from the axis and increases. Critical currents corresponding to the jet surface layer breakdown and its complete destruction were determined.
Analysis of operation of the low-amplitude pressure pulse detonation generator with adjustable duration
Authors: Andreev S.G.
Published: November 2023

The paper presents results of the analysis conducted on the action of the low-amplitude pressure pulse detonation generator with adjustable duration, where the detonation wave affects the controlled compressible medium and propagates in the direction from the medium subjected to the shock wave compression. Analytical expressions are provided for a simple model of the process under study to calculate the pressure pulse amplitude-time characteristics on the compressible medium with the charge detonation product plane-symmetric flow and the compressible inert medium. The paper considers a scheme of experimental (laboratory) assembly. In its cylindrical channel, the detonation product quasi-one-dimensional effect on the controlled environment is realized. Results of registering dynamics of pressure alterations in the controlled environment were obtained. When comparing calculation and experiment results, the reasons causing their discrepancy were identified. If the assembly body is made of steel not subjected to heat treatment, then it becomes possible to use it five times (at least) with charges of the bulk explosives based on the hexogen with generating controlled pressure pulses of several kilobars in the condensed organic materials with duration of at least tens of microseconds. In this case, the pressure rise time at the pulse leading edge reaches approximately ten microseconds.
Methodology of the helical cylindrical compression spring design calculation
Authors: Kaverin V.A. , Pokhabov Yu.P.
Published: November 2023

Helical cylindrical compression springs are most often used in the one-time actuation mechanisms in rocket and space applications as the push drives to perform useful work in moving detachable parts of the aerospace vehicles. Such drives possess maximum energy characteristics with minimal weight and cost. The paper proposes the pusher spring design calculation methodology making it possible to take into account the design values range determined by the given initial spring parameters, where the strength condition is satisfied. The calculation methodology takes into account the spring design values range and makes it possible to create an effective computational algorithm. It is introduced for a targeted and consistent search of satisfactory solutions in designing spring units and mechanisms with the required performance and reliability (dimensions, ability to overcome resistive forces along the motion path and move control objects to the required distance, as well as strength). Based on the computational algorithm, a software program was created for the design and verifying calculation of the helical cylindrical compression springs, which makes it possible to quickly find effective solutions to be introduced in the practical activities of designers and calculators.
Deformation of the layered composite plates at low-speed contact with a rigid indenter
Authors: Le Viet Tuan
Published: November 2023

The computational finite element model of contact between a steel sphere and a composite plate was developed in the ANSYS software package. The model includes geometric description of the contact, materials management, computational mesh generation using the SOLID186 and SOLID187 finite elements, as well as the surface-to-surface contact model using the CONTA174 and TARGET170 contact elements. The paper identifies influence of the rigid sphere radius on the woven composite structure and shows areas of the local composite destruction. Satisfactory compliance was obtained between the numerical calculation results and full-scale study of a contact between rigid indenter of different radii and the fiberglass laminate. The safety factor values are provided according to four criteria. The developed model of contact between the indenter and the composite plate made it possible to obtain stress fields in the carbon-plastic composite material with the laying layers [45°, –45°]n and [45°, 90°, –45°, 0°]n. Destruction in layers based on the numerical calculation results was analyzed using various stress criteria. Carbon composite had more destroyed layers due to low strength in the transverse direction. Destruction zone in the carbon composite was larger than in the fiberglass composite, and the pattern [45°, –45°]n had a smaller damage area compared to [45°, 90°, –45°, 0°]n.
Educação do Campo no norte do Tocantins: relatos das experiências da Licenciatura em Educação do Campo na UFT
Authors: Coelho George Leonardo
Published: November 2023

Dando continuidade ao extenso projeto de entrevistas com professores e pesquisadores que se dedicam à Educação do Campo em Universidades Públicas brasileiras, o presente relato de experiência vem enriquecer esse repertório. As duas primeiras entrevistas publicadas pela Revista Brasileira de Educação do Campo trouxeram os pontos de vista e as experiências dos Professores Alessandro Pimenta (UFT) e Ramofly Bicalho (UFFR). A presente entrevista foi gentilmente concedida pelo colega e professor Maciel Cover.  Antes de apresentar a entrevista é importante algumas considerações. Conheci esse jovem pesquisador quando os cursos de Educação do Campo de Arraias e Tocantinópolis, ambos da Universidade Federal do Tocantins, estavam na batalha para implantar a Escola da Terra em 2017. Na ocasião conversamos bastante sobre a necessidade de alcançar os professores que atuam em comunidades rurais, quilombolas e indígenas. De lá para cá, nos encontramos em Congressos e Encontros sobre a Escola da Terra. Nas conversas entre as atividades, o professor Maciel demonstrou uma sensibilidade e afinidade enorme com as comunidades vítimas da expropriação fundiária ocorrida no Brasil. Por essa razão, achei oportuno convidá-lo para participar desse projeto, onde procuro realizar o registro das memórias de indivíduos dedicados à Educação do Campo. Nessa entrevista, o Prof. Dr. Maciel Cover nos contou sobre seus estudos desde as primeiras experiências no curso de Pedagogia da Terra no Rio Grande do Sul até seu estágio de pós-doutoramento em Campinas-SP, assim como, seus primeiros passos na docência até sua atuação na UFT-Tocantinópolis. Então, espero que o leitor acompanhe a entrevista concedida por esse educador assumidamente militante em prol da Educação voltada para as comunidades campesinas brasileiras.
Comparative Analysis of Sonic Velocities in Partially Saturated Rocks Containing H2, CH4, N2 and CO2
Authors: Li Jimmy Xuekai , Hu Jinghao , Zhang Tiancheng , Chen Zhongwei
Published: November 2023

The understanding of the seismic signature of the partially saturated formation is critical to seismic monitoring in the hydrogen geo-storage, CO2 geo-sequestration and geophysical survey and exploration of oil and gas reservoir. The main objective of this study is to model the wave propagation in partially saturated rocks containing two immiscible fluids (i.e., gas-water), with a comparative case study on hydrogen (H2), methane (CH4), nitrogen (N2) and carbon dioxide (CO2) bearing rocks. The sonic velocities and the attenuations are influenced by several parameters, which interact in a complex pattern, particularly when the rock is saturated with multiple fluids. We developed a rock physics model that considers the effects of patchy saturation, wettability, effective pressure, and relative permeability. By examining wave propagation in each fluid-saturated case against water saturation, we improve our understanding of sonic velocity changes as water saturation varies. This provides valuable insights for seismic and sonic monitoring during the injection and extraction of H2, CH4, N2 and CO2.