bluuebunny/crossref_metadata_2025 huggingface dataset:
Retrograde procedural memory is impaired in people with Parkinson’s disease with freezing of gait
Authors: Pauly Laure , Pauly Claire , Hansen Maxime , Schröder Valerie E. , Rauschenberger Armin , Leist Anja K. , Krüger Rejko
Published: January 2024

Background

Freezing of gait (FOG), is associated with impairment of different cognitive functions. Previous studies hypothesized that FOG may be due to a loss of automaticity.

Research question

To explore whether FOG is associated with impairment in cognitive functions, focusing on retrograde procedural memory, the memory responsible for the automatic, implicit stored procedures that have been acquired in earlier life stages.

Methods

In this cross-sectional, case–control study, 288 people with typical Parkinson’s disease (PD) from the Luxembourg Parkinson’s Study were assigned to Freezers (FOG+) and non-Freezers (FOG−) based on the MDS-UPDRS 2.13 (self-reported FOG episodes) and 3.11 (FOG evaluated by clinicians during gait assessment). Both groups were matched on age, sex and disease duration. Global cognition (MoCA), retrograde procedural memory and visuo-constructive abilities (CUPRO), psychomotor speed and mental flexibility (TMT) were assessed. Furthermore, we repeated our analyses by additionally controlling for depression (BDI-I).

Results

Besides lower global cognition (MoCA; p = 0.007) and mental flexibility (TMT-B and Delta-TMT; p < 0.001), FOG+ showed a lower performance in retrograde procedural memory (CUPRO-IS1; p < 0.001) compared to FOG−. After controlling additionally for depression, our main outcome variable CUPRO-IS1 remained significantly lower in FOG+ (p = 0.010).

Conclusion

Our findings demonstrated that besides lower global cognition and mental flexibility scores, FOG+ showed lower performance in retrograde procedural memory compared to matched FOG-control patients, even when accounting for factors such as age, sex, disease duration or depression.

Significance

In the context of limited treatment options, especially for non-invasive therapeutic approaches, these insights on procedural memory and FOG may lead to new hypotheses on FOG etiology and consequently the development of new treatment options.
Age-related changes in the primary auditory cortex of newborn, adults and aging bottlenose dolphins (Tursiops truncatus) are located in the upper cortical layers
Authors: Graïc Jean-Marie , Corain Livio , Finos Livio , Vadori Valentina , Grisan Enrico , Gerussi Tommaso , Orekhova Ksenia , Centelleghe Cinzia , Cozzi Bruno , Peruffo Antonella
Published: January 2024

Introduction

The auditory system of dolphins and whales allows them to dive in dark waters, hunt for prey well below the limit of solar light absorption, and to communicate with their conspecific. These complex behaviors require specific and sufficient functional circuitry in the neocortex, and vicarious learning capacities. Dolphins are also precocious animals that can hold their breath and swim within minutes after birth. However, diving and hunting behaviors are likely not innate and need to be learned. Our hypothesis is that the organization of the auditory cortex of dolphins grows and mature not only in the early phases of life, but also in adults and aging individuals. These changes may be subtle and involve sub-populations of cells specificall linked to some circuits.

Methods

In the primary auditory cortex of 11 bottlenose dolphins belonging to three age groups (calves, adults, and old animals), neuronal cell shapes were analyzed separately and by cortical layer using custom computer vision and multivariate statistical analysis, to determine potential minute morphological differences across these age groups.

Results

The results show definite changes in interneurons, characterized by round and ellipsoid shapes predominantly located in upper cortical layers. Notably, neonates interneurons exhibited a pattern of being closer together and smaller, developing into a more dispersed and diverse set of shapes in adulthood.

Discussion

This trend persisted in older animals, suggesting a continuous development of connections throughout the life of these marine animals. Our findings further support the proposition that thalamic input reach upper layers in cetaceans, at least within a cortical area critical for their survival. Moreover, our results indicate the likelihood of changes in cell populations occurring in adult animals, prompting the need for characterization.
Vehicle re-identification method based on multi-attribute dense linking network combined with distance control module
Authors: Sun Xiaoming , Chen Yan , Duan Yan , Wang Yongliang , Zhang Junkai , Su Bochao , Li Li
Published: January 2024

Introduction

Vehicle re-identification is a crucial task in intelligent transportation systems, presenting enduring challenges. The primary challenge involves the inefficiency of vehicle re-identification, necessitating substantial time for recognition within extensive datasets. A secondary challenge arises from notable image variations of the same vehicle due to differing shooting angles, lighting conditions, and diverse camera equipment, leading to reduced accuracy. This paper aims to enhance vehicle re-identification performance by proficiently extracting color and category information using a multi-attribute dense connection network, complemented by a distance control module.

Methods

We propose an integrated vehicle re-identification approach that combines a multi-attribute dense connection network with a distance control module. By merging a multi-attribute dense connection network that encompasses vehicle HSV color attributes and type attributes, we improve classification rates. The integration of the distance control module widens inter-class distances, diminishes intra-class distances, and boosts vehicle re-identification accuracy.

Results

To validate the feasibility of our approach, we conducted experiments using multiple vehicle re-identification datasets. We measured various quantitative metrics, including accuracy, mean average precision, and rank-n. Experimental results indicate a significant enhancement in the performance of our method in vehicle re-identification tasks.

Discussion

The findings of this study provide valuable insights into the application of multi-attribute neural networks and deep learning in the field of vehicle re-identification. By effectively extracting color information from the HSV color space and vehicle category information using a multi-attribute dense connection network, coupled with the utilization of a distance control module to process vehicle features, our approach demonstrates improved performance in vehicle re-identification tasks, contributing to the advancement of smart city systems.
Intelligence and executive function are associated with age at insult, time post-insult, and disability following chronic pediatric acquired brain injury
Authors: Brandt Anne Elisabeth , Rø Torstein B. , Finnanger Torun G. , Hypher Ruth E. , Lien Espen , Lund Bendik , Catroppa Cathy , Andersson Stein , Risnes Kari , Stubberud Jan
Published: January 2024

Background

Pediatric acquired brain injury (pABI) profoundly affects cognitive functions, encompassing IQ and executive functions (EFs). Particularly, young age at insult may lead to persistent and debilitating deficits, affecting daily-life functioning negatively. This study delves into the intricate interplay of age at insult, time post-insult, and their associations with IQ and EFs during chronic (>1 year) pABI. Additionally, we investigate cognitive performance across different levels of global function, recognizing the multifaceted nature of developmental factors influencing outcomes.

Methods

Drawing upon insult data and baseline information analyzing secondary outcomes from a multicenter RCT, including comprehensive medical and neuropsychological assessments of participants aged 10 to 17 years with pABI and parent-reported executive dysfunctions. The study examined associations between age at insult (early, EI; ≤7y vs. late, LI; > 7y) and time post-insult with IQ and EFs (updating, shifting, inhibition, and executive attention). Additionally, utilizing the Pediatric Glasgow Outcome Scale-Extended, we explored cognitive performance across levels of global functioning.

Results

Seventy-six participants, median 8 years at insult and 5 years post-insult, predominantly exhibiting moderate disability (n = 38), were included. Notably, participants with LI demonstrated superior IQ, executive attention, and shifting compared to EI, [adjusted mean differences with 95% Confidence Intervals (CIs); 7.9 (1.4, 14.4), 2.48 (0.71, 4.24) and 1.73 (0.03, 3.43), respectively]. Conversely, extended post-insult duration was associated with diminished performances, evident in mean differences with 95% CIs for IQ, updating, shifting, and executive attention compared to 1–2 years post-insult [−11.1 (−20.4, −1.7), −8.4 (−16.7, −0.1), −2.6 (−4.4, −0.7), −2.9 (−4.5, −1.2), −3.8 (−6.4, −1.3), −2.6 (−5.0, −0.3), and −3.2 (−5.7, −0.8)]. Global function exhibited a robust relationship with IQ and EFs.

Conclusion

Early insults and prolonged post-insult durations impose lasting tribulations in chronic pABI. While confirmation through larger studies is needed, these findings carry clinical implications, underscoring the importance of vigilance regarding early insults. Moreover, they dispel the notion that children fully recover from pABI; instead, they advocate equitable rehabilitation offerings for pABI, tailored to address cognitive functions, recognizing their pivotal role in achieving independence and participation in society. Incorporating disability screening in long-term follow-up assessments may prove beneficial.
Nimodipine systemic exposure and outcomes following aneurysmal subarachnoid hemorrhage: a pilot prospective observational study (ASH-1 study)
Authors: Mahmoud Sherif Hanafy , Hefny Fatma , Isse Fadumo Ahmed , Farooq Shahmeer , Ling Spencer , O'Kelly Cian , Kutsogiannis Demetrios James
Published: January 2024

Background

Nimodipine improves outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Guidelines recommend that all patients should receive a fixed-dose nimodipine for 21 days. However, studies reported variability of nimodipine concentrations in aSAH. It is not clear if reduced systemic exposure contributes to worsening outcomes. The aim of this study was to compare nimodipine systemic exposure in those who experienced poor outcomes to those who experienced favorable outcomes.

Methods

This was a pilot prospective observational study in 30 adult patients admitted to the University of Alberta Hospital with aSAH. Data were collected from the electronic health records following enrollment. Blood samples were collected around one nimodipine 60 mg dose at a steady state, and nimodipine [total, (+)-R and (−)-S enantiomers] plasma concentrations were determined. The poor outcome was defined as a modified Rankin Scale (mRS) score at 90 days of 3-6, while the favorable outcome was an mRS score of 0-2. The correlation between nimodipine concentrations and percent changes in mean arterial pressure (MAP) before and after nimodipine administration was also determined. Furthermore, covariates potentially associated with nimodipine exposure were explored.

Results

In total, 20 (69%) participants had favorable outcomes and 9 (31%) had poor outcomes. Following the exclusion of those with delayed presentation (>96 h from aSAH onset), among those presented with the World Federation of Neurological Surgeons (WFNS) grade 3–5, nimodipine median (interquartile range) area under the concentration time curve (AUC0-3h) in those with favorable outcomes were 4-fold higher than in those with poor outcomes [136 (52–192) vs. 33 (23–39) ng.h/mL, respectively, value of p = 0.2]. On the other hand, among those presented with WFNS grade 1–2, nimodipine AUC0-3h in those with favorable outcomes were significantly lower than in those with poor outcomes [30 (28–36) vs. 172 (117–308) ng.h/mL, respectively, value of p = 0.03)]. (+)-R-nimodipine AUC0-3h in those who did not develop vasospasm were 4-fold significantly higher than those who had vasospasm (value of p = 0.047). (−)-S-nimodipine was significantly correlated with percentage MAP reduction. Similar results were obtained when the whole cohort was analyzed.

Conclusion

The study was the first to investigate the potential association between nimodipine exposure following oral dosing and outcomes. In addition, it suggests differential effects of nimodipine enantiomers, shedding light on the potential utility of nimodipine enantiomers. Larger studies are needed.
Association between migraine and epilepsy: a meta-analysis
Authors: Wu Xiaohui , Zhuang Jiaxin
Published: January 2024

Background

Epidemiological studies have demonstrated a comorbid association between migraine and epilepsy. However, despite the long history of this association, the exact nature of the relationship between migraine and epilepsy remains largely unresolved. Therefore, it is crucial to conduct a meta-analysis in order to thoroughly investigate the relationship between migraine and epilepsy.

Methods

Odds ratios (ORs) or relative risks (RRs) and 95% confidence intervals (CIs) regarding association between migraine and epilepsy were summarized using STATA 12.0 software.

Results

There was an 80% increase in the lifetime prevalence of migraine among patients with epilepsy, compared to those without epilepsy with a random effects model (OR/RR: 1.80, 95% CI: 1.35 to 2.40, I2 = 97.5%, p < 0.001). There was an 80% increase in the lifetime prevalence of epilepsy among patients with migraine, compared to those without migraine with a random effects model (OR/RR: 1.80, 95% CI: 1.43 to 2.25, I2 = 80.6%, p < 0.001).

Conclusions

It is important to note the comorbid association between migraine and epilepsy examined in the study.
Peripheral and central changes induced by neural mobilization in animal models of neuropathic pain: a systematic review
Authors: Salniccia Federico , de Vidania Silvia , Martinez-Caro Leticia
Published: January 2024

Introduction

Neural mobilization (NM) is a physiotherapy technique involving the passive mobilization of limb nerve structures with the aim to attempt to restore normal movement and structural properties. In recent years, human studies have shown pain relief in various neuropathic diseases and other pathologies as a result of this technique. Improvement in the range of motion (ROM), muscle strength and endurance, limb function, and postural control were considered beneficial effects of NM. To determine which systems generate these effects, it is necessary to conduct studies using animal models. The objective of this study was to gather information on the physiological effects of NM on the peripheral and central nervous systems (PNS and CNS) in animal models.

Methods

The search was performed in Medline, Pubmed and Web of Science and included 8 studies according to the inclusion criteria.

Results

The physiological effects found in the nervous system included the analgesic, particularly the endogenous opioid pathway, the inflammatory, by modulation of cytokines, and the immune system.

Conclusion

On the basis of these results, we can conclude that NM physiologically modifies the peripheral and central nervous systems in animal models.
The light side of gaming: creativity and brain plasticity
Authors: Ganter-Argast Christiane , Schipper Marc , Shamsrizi Manouchehr , Stein Christian , Khalil Radwa
Published: January 2024

Could gaming enhance brain plasticity and executive functions (EFs) by fostering creativity? We identify vital benefits from further research exploring the relationship between games, brain plasticity, and creativity. The ongoing progress in neuroscience research in these three disciplines offers many possibilities and prospects for impactful therapy. Therefore, we emphasize the significance of investigating the untapped potentials of using games in creative therapy—our perspective on the often-overlooked neuroscientific aspect of creativity concerning health and wellbeing. One of these potentials is examining games as a therapeutic tool, focusing on their capacity to inspire and engage the imagination and other mental operators shared with creativity. Using a game as a therapeutic approach may boost brain plasticity, which may help them reduce their cognitive impairments by improving their EFs. This review offers a comprehensive outline of the latest advancements in the literature on games that tie to creativity through enhancing brain plasticity and EFs. Communicating this knowledge can furnish countless possibilities to improve our overall health and wellbeing and foster a positive perspective in individuals affected by anxiety.
Community mobility and participation assessment of manual wheelchair users: a review of current techniques and challenges
Authors: Fasipe Grace , Goršič Maja , Rahman Mohammad Habibur , Rammer Jacob
Published: January 2024

According to the World Health Organization, hundreds of individuals commence wheelchair use daily, often due to an injury such as spinal cord injury or through a condition such as a stroke. However, manual wheelchair users typically experience reductions in individual community mobility and participation. In this review, articles from 2017 to 2023 were reviewed to identify means of measuring community mobility and participation of manual wheelchair users, factors that can impact these aspects, and current rehabilitation techniques for improving them. The selected articles document current best practices utilizing self-surveys, in-clinic assessments, and remote tracking through GPS and accelerometer data, which rehabilitation specialists can apply to track their patients’ community mobility and participation accurately. Furthermore, rehabilitation methods such as wheelchair training programs, brain-computer interface triggered functional electric stimulation therapy, and community-based rehabilitation programs show potential to improve the community mobility and participation of manual wheelchair users. Recommendations were made to highlight potential avenues for future research.
Is endovascular treatment still good for acute ischemic stroke in the elderly? A meta-analysis of observational studies in the last decade
Authors: Jiang Xin , Wang Jian , Hu Yaowen , Lang Hui , Bao Jiajia , Chen Ning , He Li
Published: January 2024

Background

The lack of randomized evidence makes it difficult to establish reliable treatment recommendations for endovascular treatment (EVT) in elderly patients. This meta-analysis aims to evaluate the therapeutic effects of endovascular treatment for acute ischemic stroke in the elderly compared with younger patients.

Methods

Comprehensive literature retrieval was conducted to identify studies that directly compared the outcomes of EVT in elderly patients and those aged <80 years. The primary outcome was functional independence, defined as mRS 0–2 at 90 days after EVT. The secondary outcomes were the rate of successful recanalization, symptomatic intracranial hemorrhage (sICH) and mortality. Odds ratios (ORs) were estimated using a random effects model.

Results

In total, twenty-six studies with 9,492 enrolled participants were identified. Our results showed that, compared with patients aged <80 years undergoing EVT, EVT was associated with a lower rate of functional independence at 90 days (OR = 0.38; 95% CI, 0.33–0.45; p < 0.00001) and a higher mortality rate (OR = 2.51; 95% CI, 1.98–3.18; p < 0.00001) in the elderly. Furthermore, even without a significantly observed increase in sICH (OR = 1.19; 95% CI, 0.96–1.47; p = 0.11), EVT appeared to be associated with a lower rate of successful recanalization (OR = 0.81; 95% CI, 0.68–0.96; p = 0.02).

Conclusion

Evidence from observational studies revealed that EVT has less functional outcomes in elderly patients with acute ischemic stroke. Further studies are needed to better identify patients aged ≥80 years who could potentially benefit from EVT.
Emerging perspectives of synaptic biomarkers in ALS and FTD
Authors: Krishnamurthy Karrthik , Pradhan Raj Kumar
Published: January 2024

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are debilitating neurodegenerative diseases with shared pathological features like transactive response DNA-binding protein of 43 kDa (TDP-43) inclusions and genetic mutations. Both diseases involve synaptic dysfunction, contributing to their clinical features. Synaptic biomarkers, representing proteins associated with synaptic function or structure, offer insights into disease mechanisms, progression, and treatment responses. These biomarkers can detect disease early, track its progression, and evaluate therapeutic efficacy. ALS is characterized by elevated neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) and blood, correlating with disease progression. TDP-43 is another key ALS biomarker, its mislocalization linked to synaptic dysfunction. In FTD, TDP-43 and tau proteins are studied as biomarkers. Synaptic biomarkers like neuronal pentraxins (NPs), including neuronal pentraxin 2 (NPTX2), and neuronal pentraxin receptor (NPTXR), offer insights into FTD pathology and cognitive decline. Advanced technologies, like machine learning (ML) and artificial intelligence (AI), aid biomarker discovery and drug development. Challenges in this research include technological limitations in detection, variability across patients, and translating findings from animal models. ML/AI can accelerate discovery by analyzing complex data and predicting disease outcomes. Synaptic biomarkers offer early disease detection, personalized treatment strategies, and insights into disease mechanisms. While challenges persist, technological advancements and interdisciplinary efforts promise to revolutionize the understanding and management of ALS and FTD. This review will explore the present comprehension of synaptic biomarkers in ALS and FTD and discuss their significance and emphasize the prospects and obstacles.
Egg consumption and growth in children: a meta-analysis of interventional trials
Authors: Larson Elisabeth A. , Zhao Zaixin , Bader-Larsen Karlen S. , Magkos Faidon
Published: January 2024

Introduction

Stunting and wasting are prevalent in low- and middle-income countries, putting children at risk for disease and disability. Eggs are a nutrient-rich food that can potentially facilitate growth.

Purpose

The aim of this meta-analysis was to evaluate the potential beneficial effect of egg supplementation on growth in children.

Methods

Following the PRISMA guidelines, PubMed and Healthline (Ovid) were systematically searched for interventional studies on egg supplementation for growth in children aged 6 months to 18 years, with no restrictions on date. Studies were evaluated for quality using Cochrane’s GRADE technique. Data were pooled and reported as means and 95% confidence intervals.

Results

Seven studies reporting on 9 unique interventions in 3,575 male and female participants were included in the meta-analysis. Participants in the intervention groups experienced significantly greater increases in height/length (by 0.47 [0.13, 0.80] cm, p < 0.01) and weight (by 0.07 [0.01, 0.13] kg, p = 0.03) when compared to those in the control groups.

Conclusion

Eggs are an affordable, nutritious option for improving growth in children, though more studies with longer interventions are warranted.

Systematic review registration: PROSPERO (CRD42021289609: https://www.crd.york.ac.uk/prospero/).
Global trends and research hotspots of EAT-Lancet diet: a bibliometric analysis
Authors: Lin Xiaoxiao , Wang Shuai , Gao Yue
Published: January 2024

The EAT-Lancet diet is a groundbreaking and comprehensive dietary framework that has garnered significant attention in the fields of nutrition, sustainability, and public health. We aimed to conduct a bibliometric study to investigate current status and hotspots in the field of EAT-Lancet diet based on the Web of Science Core Collection (WOSCC) database, and the documents of EAT-Lancet diet published from Jan 1, 2019 to Sep 1.2023 were extracted. The bibliometric and visualized analysis were performed by VOSviewer 1.6.16 and WOSCC Online Analysis Platform. In total, 155 documents from 62 journals were included, and 735 authors from 389 institutions and 53 countries/regions contributed to the field of EAT-Lancet diet. The most productive countries/regions, institutions, authors, and journals were the USA, Wageningen University & Research, Johan Rockström, and Nutrients, respectively. The first high-cited document was published in Lancet and authored by Willett et al. in 2019. This is also the first study about EAT-Lancet diet. The article firstly proposed the “EAT-Lancet Diet” emphasizing balanced, plant-based eating to improve human health while addressing environmental concerns. In conclusion, in the field of EAT-Lancet diet, the main research hotspots and frontiers are the adaptation of EAT-Lancet diet, the composition of EAT-Lancet diet, and the benefits of EAT-Lancet diet for human health. The number of research on the EAT-Lancet diet is currently limited. There is a pressing need for further studies to broaden our understanding of the EAT-Lancet diet and its potential to enhance human health.
Oral ingestion of Shiikuwasha extract suppresses diabetes progression in db/db mice by preserving β-cell mass
Authors: Kaji Megumi , Kaneko Yukiko K. , Ihim Stella Amarachi , Kanoh Ran , Yamamoto Moe , Yamaguchi Momoka , Ishikawa Tomohisa
Published: January 2024

Introduction

Nobiletin is a polymethoxyflavonoid abundant in citrus peels and has been reported to have various bioactive effects. We have previously reported that nobiletin inhibits endoplasmic reticulum stress-induced apoptosis in the pancreatic β-cell line INS-1 and that continuous subcutaneous administration of nobiletin suppresses the progression of diabetes by protecting β-cells in type 2 diabetic db/db mice. In the present study, we investigated effects of oral ingestion of Shiikuwasha extract rich in nobiletin on the pathogenesis of type 2 diabetes in db/db mice.

Materials and methods

A Shiikuwasha extract was dissolved in MediDrop sucralose. Twenty-four mice were equally divided in three groups and fed with vehicle or low or high dose of Shiikuwasha extract for 4 weeks. Blood glucose levels, pancreatic β-cell mass, serum insulin levels, pancreatic insulin content, and other biomarkers were measured and compared between the groups.

Results

The group that freely ingested the Shiikuwasha extract containing higher concentration of nobiletin (Shiikuwasha H) showed lower blood glucose levels. At the end of the experiment, the Shiikuwasha H group exhibited improved glucose tolerance, lower serum glycoalbumin levels, and an increase in β-cell area per pancreas compared with the control group. Body weight, food intake, and serum biomarkers related to liver function and lipid metabolism of the Shiikuwasha H group were not different from those of the control group, although water intake of the former was significantly decreased than that of the latter.

Conclusion

Our results suggest that the oral ingestion of Shiikuwasha extract preserves pancreatic β-cell mass in diabetic mice, which might be attributed to ameliorating the progression of diabetes.
Impact of a Mediterranean diet, physical activity, body composition, and insulin delivery methods on metabolic control in children with type 1 diabetes
Authors: Nóvoa-Medina Yeray , Pérez-Lemes Alicia , Suárez-Ramírez Nerea , Barreiro-Bautista Marta , Fabelo Himar , López-López Sara , Quinteiro Sofia , Domínguez Angela , León Marta , González María A. , Caballero Elisabeth , Wägner Ana M.
Published: January 2024

Aims

To evaluate the synergistic impact of diet, lifestyle and technology on glycemic control in children with type 1 diabetes (T1D).

Methods

This cross-sectional study included 112 randomly selected patients with T1D from Gran Canaria (median age 12 years; 51.8% female). The study collected data on height, weight, body composition (bioimpedance), age, disease duration, and method of insulin delivery. Physical activity was evaluated using the Krece questionnaire and an accelerometer (GENEActiv). Adherence to the Mediterranean diet was assessed using the KIDMED Quick Nutrition Test. Glycemic control was evaluated using HbA1c and the percentage of time in range. SPSS version 21 and RStudio were used for statistical analysis of the data. Stepwise linear regression analysis (backwards) was used to identify factors independently associated with metabolic control.

Results

Insulin pump use, age and adherence to the Mediterranean diet were found to be significantly and independently associated with better glycemic control, whereas years with T1D was associated with worse HbA1c values. No relationship was found between body composition and physical activity measured by accelerometry or questionnaire.

Conclusion

Adherence to the Mediterranean diet, insulin delivery methods, age, and number of years with T1D are important factors to consider in the management of T1D in children.
Providing holistic care to children with cerebral palsy treated with transnasal neural stem cell transplantation
Authors: Li Xiaoyan , Li Mengyao , Qin Xixian , Li Ying , Wang Yachen , Han Chao , Ni Shiwei , Sun Xuna , Dong Peipei , Liu Jing
Published: January 2024

Objective

Holistic care is a key element in nursing care. Aiming at the heterogeneous disease of cerebral palsy, researchers focused on children with cerebral palsy who received transnasal transplantation of neural stem cells as a specific group. Based on establishing a multidisciplinary team, comprehensive care is carried out for this type of patient during the perioperative period to improve the effectiveness and safety of clinical research and increase the comfort of children.

Methods

Between January 2018 and June 2023, 22 children with cerebral palsy underwent three transnasal transplants of neural stem cells.

Results

No adverse reactions related to immune rejection were observed in the 22 children during hospitalization and follow-up. All children tolerated the treatment well, and the treatment was superior. One child developed nausea and vomiting after sedation; three had a small amount of bleeding of nasal mucosa after transplantation. Two children had a low fever (≤38.5°C), and one had a change in the type and frequency of complex partial seizures. Moreover, 3 children experienced patch shedding within 4 h of patch implantation into the nasal cavity.

Conclusion

The project team adopted nasal stem cell transplantation technology. Based on the characteristics of transnasal transplantation of neural stem cells in the treatment of neurological diseases in children, a comprehensive and novel holistic care plan is proposed. It is of great significance to guide caregivers of children to complete proper care, further improve the safety and effectiveness of treatment, and reduce the occurrence of complications.
Endosperm structure and Glycemic Index of Japonica Italian rice varieties
Authors: Haxhari Filip , Savorani Francesco , Rondanelli Mariangela , Cantaluppi Enrico , Campanini Luigi , Magnani Edoardo , Simonelli Cinzia , Gavoci Gentian , Chiadò Alessandro , Sozzi Mattia , Cavallini Nicola , Chiodoni Angelica , Gasparri Clara , Barrile Gaetan Claude , Cavioni Alessandro , Mansueto Francesca , Mazzola Giuseppe , Moroni Alessia , Patelli Zaira , Pirola Martina , Tartara Alice , Guido Davide , Perna Simone , Magnaghi Roberto
Published: January 2024

Introduction

Given that rice serves as a crucial staple food for a significant portion of the global population and with the increasing number of individuals being diagnosed with diabetes, a primary objective in genetic improvement is to identify and cultivate low Glycemic Index (GI) varieties. This must be done while ensuring the preservation of grain quality.

Methods

25 Italian rice genotypes were characterized calculating their GI “in vivo” and, together with other 29 Italian and non-Italian genotypes they were studied to evaluate the grain inner structure through Field Emission Scanning Electron Microscopy (FESEM) technique. Using an ad-hoc developed algorithm, morphological features were extracted from the FESEM images, to be then inspected by means of multivariate data analysis methods.

Results and Discussion

Large variability was observed in GI values (49 to 92 with respect to glucose), as well as in endosperm morphological features. According to the percentage of porosity is possible to distinguish approximately among rice varieties having a crystalline grain (< 1.7%), those intended for the preparation of risotto (> 5%), and a third group having intermediate characteristics. Waxy rice varieties were not united by a certain porosity level, but they shared a low starch granules eccentricity. With reference to morphological features, rice varieties with low GI (<55) seem to be characterized by large starch granules and low porosity values. Our data testify the wide variability of Italian rice cultivation giving interesting information for future breeding programs, finding that the structure of the endosperm can be regarded as a specific characteristic of each variety.
Empirical legitimacy as core of comparative democracy research
Authors: Pickel Gert , Pickel Susanne
Published: January 2024

Legitimacy is a central resource for all political systems. This include democracies as autocracies. For democracies, you need the acceptance of the normative concept of democracy by the citizens. Simply put, this norm requires an empirical legitimacy. The empirical legitimacy focus on different understandings of democracy. Mostly the aspect of individual freedom is dominant. Empirical analyses show this idea do not only work for Europe. The article first shows what empirical legitimacy means conceptually and then analyzes this existence of legitimacy in a comparative perspective. It is the erosion of legitimacy that can lead a political regime to collapse. Current survey data from political culture research show not only differences in the legitimacy of democratic and autocratic regimes, but also an increase in the importance of different understandings of democracy. Some of these are no longer democratic.
A conceptual framework on body representations and their relevance for mental disorders
Authors: Möllmann Anne , Heinrichs Nina , Herwig Arvid
Published: January 2024

Many mental disorders are accompanied by distortions in the way the own body is perceived and represented (e.g., eating disorders, body dysmorphic disorder including muscle dysmorphia, or body integrity dysphoria). We are interested in the way these distortions develop and aim at better understanding their role in mental health across the lifespan. For this purpose, we first propose a conceptual framework of body representation that defines this construct and integrates different perspectives (e.g., cognitive neuroscience, clinical psychology) on body representations. The framework consists of a structural and a process model of body representation emphasizing different goals: the structural model aims to support researchers from different disciplines to structure results from studies and help collectively accumulate knowledge about body representations and their role in mental disorders. The process model is reflecting the dynamics during the information processing of body-related stimuli. It aims to serve as a motor for (experimental) study development on how distorted body representations emerge and might be changed. Second, we use this framework to review the normative development of body representations as well as the development of mental disorders that relate to body representations with the aim to further clarify the potential transdiagnostic role of body representations.
Adaptive aspects of maximizing in times of COVID-19: coping efforts linking maximization to well-being
Authors: Jun Young Joo , Choi Incheol , Kim Joo Hyun
Published: January 2024

Introduction

Maximization, the tendency to make the best choices by thoroughly searching and comparing alternatives, has long been considered a negative correlate of well-being. However, recently, it was proposed that having a maximizing tendency can lead to better coping efforts in some stressful situations and thus could be more adaptive. The objective of the present research was to demonstrate positive features of maximization and identify the coping strategies that mediate the relationship between maximization and well-being during the COVID-19 pandemic.

Methods

A sample of 3,493 participants responded to an online survey from January 20 to October 11 of 2020. The 13-item Maximization Scale assessed individuals’ maximizing tendency in terms of the maximization index and its three subdimensions (i.e., high standards, alternative search, and decision difficulty). The use of four coping strategies (i.e., preventive measures, cognitive appraisal, self-distraction, and social connection) during the COVID-19 pandemic was assessed. Hedonic and eudaimonic aspects of well-being were measured. We developed a mediation model and examined both whether there was an indirect link between maximization and well-being through the coping strategies and whether there was a direct link between maximization and well-being.

Results

Path analysis revealed negative direct associations between maximization measures (i.e., an index and three subdimensions) and well-being. In addition, significant indirect paths were found with varying directions depending on maximization dimensions and coping strategy types. There were positive indirect associations between the maximization index and well-being via preventive measures, between high standards and well-being through preventive measures and cognitive appraisal, and between alternative search and well-being through self-distraction and social connection. Negative indirect associations were found between decision difficulty and well-being through cognitive appraisal, self-distraction, and social connection.

Discussion

The current study confirmed the existence of inconsistent mediation effects between maximization and well-being via coping and highlighted coping efforts as one of the positive aspects of maximization. Discussion addressed the double-edged effect of maximization on well-being and its beneficial nature in times of distress. Future studies should examine other potential situations and moderators that can delineate maximization’s various characteristics with a longitudinal design and samples from diverse backgrounds.
The Gender Euphoria Scale (GES): a protocol for developing and validating a tool to measure gender euphoria in transgender and gender diverse individuals
Authors: Blacklock C. A. , Tollit M. A. , Pace C. C. , Elphinstone B. , Pang K. C. , Buzwell S.
Published: January 2024

Background

Gender euphoria (i.e., a positive feeling associated with one’s gender identity, expression, or affirmation) is widely discussed among transgender and gender diverse (hereafter referred to as trans) individuals. However, as a construct, gender euphoria has never been formally measured and has rarely been empirically studied. Hence, this protocol paper illustrates our process for developing and validating a new tool to measure gender euphoria, known as the Gender Euphoria Scale (GES), for use with trans populations.

Methods

Deductive methods including findings from previous research and a review of existing measures, together with inductive methods such as expert feedback and focus groups with trans individuals, were used to generate a preliminary item pool for the GES. Pilot testing with trans community members and mental health clinicians was then used to refine items and develop a preliminary scale. Trans participants involved in an ongoing longitudinal study (TRANSform) were invited to complete the scale alongside measures of personality and gender factors to assess validity. Participants were then invited to complete the scale two weeks after initial completion to assess the test–retest reliability of the scale. The next stage in the scale development process will be to examine the dimensionality of the GES using exploratory factor analytic techniques. The scale will then be assessed for internal consistency, temporal stability, discriminant validity, and convergent validity.

Conclusion

This paper outlines the development and characterization of a novel tool to measure gender euphoria for the first time. The GES will facilitate research opportunities to better understand the nature of gender euphoria and its influences, and may be used clinically to examine relationships between gender euphoria and gender affirming interventions. Hence, we expect the GES to make a significant contribution to both research and clinical practice with trans communities.
Examining the relation between emotional experiences and emotional expressions in competitive tennis matches
Authors: Fritsch Julian , Fiedler Janis , Hatzigeorgiadis Antonis , Jekauc Darko
Published: January 2024

Introduction

Emotions consist of different components such as the emotional experience, physiological reactions, action tendencies, or emotional expressions. Assessing the relation of these components may help to better understand the role of emotions in sport competitions. Based on the component process model of emotions, the goal of the present study was to assess the relation between emotional experiences and emotional expressions.

Methods

Twenty tennis players (7 female) with an average age of 23.10 (SD = 4.88) were taped during competitive tennis matches. Thereafter, in individual meetings, after having watched themselves on the footage at pre-selected points, the players had to indicate whether, immediately after the end of a rally, they had a positive or a negative emotional experience and, in case they had one, rate its intensity. Moreover, based on their observable behavior, the players were also asked to state whether they could recognize a positive or a negative emotional expression and, in case they recognized one, rate its intensity. The occurrence of emotional expressions was additionally rated by two external coders. Using multilevel models, separate analyses were conducted for positive emotions after won points and negative emotions after lost points.

Results and discussion

For both positive and negative emotions, the results indicated a positive correlation between emotional experiences and emotional expressions. Moreover, the intensity of emotional experiences could predict the occurrence of an emotional expression rated by both the players or external coders. These insights into the relation between emotional experiences and emotional expressions may help players to more effectively regulate their emotions.
Research on the impact of the socio-educational environment on the academic performance of college students: the mediating role of study motivation
Authors: Wang Weiqin , Han Lu , Lu Qingjiao , Lv Xingjun , Liu Yu , Wang Dongxuan
Published: January 2024

Background

Enhancing the academic performance (AP) of college students can contribute to the overall scientific literacy among this population, thereby fostering societal progress.

Objective

The study investigates the correlation between college students’ AP and the socio-educational environment (SEE, including family, roommates, and teachers), study motivation (SM, including self-efficacy and study behaviors). Based on the research findings, recommendations are offered to students, educators, and school administrators.

Settings

Utilizing a stratified sampling approach, data was collected by selecting a sample of 330 first-year computer science students from a specific local university in Hebei Province, China.

Methods

Data will be collected through a hierarchical sampling method. Using correlation analysis, difference analysis, and structural equation modeling (SEM) as data analysis methods. The data passed reliability and validity analysis (Cronbach’s Alpha = 0.88, KMO = 0.88, χ2/df = 1.49RMSEA = 0.04).

Results

The independent sample T-test results showed that female students had higher academic performance than male students (p < 0.001), and there was no significant difference in academic performance between students from single parent or orphan families and students from normal families (p = 0.14), from non urban areas and from urban areas (p = 0.67). The results of the mediating effect analysis indicate that SM exerts complete mediation in the association between SEE and AP, with a mediating effect value of 0.18.

Conclusion

The educational disparity between urban and rural areas in China is gradually narrowing. Support policies for students from impoverished families in higher education institutions are showing initial effectiveness. The conducive learning environment and educational atmosphere for students can indirectly influence their psychological state, thus impacting their academic performance during their university years.
Relieving the burden of intensive labeling for stress monitoring in the wild by using semi-supervised learning
Authors: Başaran Osman Tugay , Can Yekta Said , André Elisabeth , Ersoy Cem
Published: January 2024

Stress, a natural process affecting individuals' wellbeing, has a profound impact on overall quality of life. Researchers from diverse fields employ various technologies and methodologies to investigate it and alleviate the negative effects of this phenomenon. Wearable devices, such as smart bands, capture physiological data, including heart rate variability, motions, and electrodermal activity, enabling stress level monitoring through machine learning models. However, labeling data for model accuracy assessment poses a significant challenge in stress-related research due to incomplete or inaccurate labels provided by individuals in their daily lives. To address this labeling predicament, our study proposes implementing Semi-Supervised Learning (SSL) models. Through comparisons with deep learning-based supervised models and clustering-based unsupervised models, we evaluate the performance of our SSL models. Our experiments show that our SSL models achieve 77% accuracy with a classifier trained on an augmented dataset prepared using the label propagation (LP) algorithm. Additionally, our deep autoencoder network achieves 76% accuracy. These results highlight the superiority of SSL models over unsupervised learning techniques and their comparable performance to supervised learning models, even with limited labeled data. By relieving the burden of labeling in daily life stress recognition, our study advances stress-related research, recognizing stress as a natural process rather than a disease. This facilitates the development of more efficient and accurate stress monitoring methods in the wild.