bluuebunny/crossref_metadata_2025 huggingface dataset:
BIOFÍSICA DA VISÃO: GLAUCOMA, ASTIGMATISMO E MIOPIA
Authors: Gonçalves Leidiane Batista , Vaz Méjane Cristina Portela , Oliveira Lelis Araújo de 
Published: February 2022

Cerca de 2,2 milhões de pessoas não enxergam direito no mundo por terem problemas de visão relacionados à miopia (25%), astigmatismo (70%) e glaucoma (2%). A visão, assim como a audição, faz parte do sistema sensorial, o qual situa aqueles que o possue em relação com o mundo ao seu redor, sendo ativo pelas sinapses do cérebro e projetados pelo globo ocular. Segundo artigos publicados por Empresas Americanas de Saúde os problemas de visão acontecem com maior frequência em adultos a partir de 40 anos e com a pré-disposição em negros por conta do excesso de pigmentação. O objetivo do presente trabalho é verificar através de um questionário estruturado qual o tipo de relação existente entre as doenças citadas (glaucoma, astigmatismo e miopia) com a cor da pele e idade de cada indivíduo. Almejamos com esse trabalho contribuir para os estudos a respeito desta relação, uma vez que existem poucas pesquisas relacionadas ao tema de biofísica da visão.
ALFABETIZAÇÃO E LETRAMENTO: CONTRIBUIÇÕES PARA O ENSINO DE MATEMÁTICA
Authors: Oliveira Astrogilda Silva de , Santos Carlos Henrique da Silva , Angelo Fabiana , Silva Giselle Carolina de Lima e , Moraes Jacques Lenoir Gusmão
Published: February 2022

O ensino de Matemática possui amplos desafios na promoção de estratégias de ensino que proporcionem estímulos e interesse aos alunos em relação ao conhecimento matemático e suas aplicações. Neste contexto, o ensino de Matemática demanda que os alunos possuam capacidade de interpretação textual, que possibilitem desenvolver a reflexão e criticidade sobre o texto, para identificar as aplicações matemáticas necessária. O objetivo geral deste estudo é discutir a importância do processo de alfabetização e letramento para o desenvolvimento do ensino de Matemática na educação básica. Este estudo se caracteriza como uma pesquisa bibliográfica. O desenvolvimento deste estudo se apresenta relevante para se compreender o processo educacional na educação básica, a partir do processo de alfabetização e letramento construído no processo de ensino-aprendizagem das séries iniciais do ensino fundamental. A importância do processo de alfabetização e letramento no ensino de Matemática na educação básica consiste no fornecimento de bases essenciais para se trabalhar a dimensão crítica do conhecimento matemático em sala de aula.
Erratum to: Bloss JE, LePrevost CE, Cofie LE, Lee JGL. Creating information resources and trainings for farmworker-serving community health workers. J Med Libr Assoc. 2022;110(1):113–118. DOI: https://doi.org/10.5195/jmla.2022.1272.
Authors: Bloss Jamie E
Published: February 2022

The following funding disclosure was left out of the manuscript during the submission and production process. The original manuscript has been updated to include this statement.

FUNDING STATEMENT

Research reported in this publication was supported by the National Library of Medicine of the National Institutes of Health under Award Number G08LM013198. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
ANALISIS PENGARUH EKSTRAK SECANG (Caesalpinia sappan L) DENGAN JUMLAH SPERMATOZOA PADA MENCIT JANTAN (Mus MusculluS L)
Authors: AMES Silfia Sekar
Published: February 2022

Terbatasnya pilihan kontrasepsi laki-laki yang dapat digunakan menjadi faktor lain penyebab rendahnya peserta KB pria. Pemanfaatan kayu secang sebagai alternatif kontrasepsi bagi laki-laki karena senyawa aktif dari kayu secang dapat mempengaruhi morfologi abnomal spermatozoa dan jumlah spermatozoa pada mencit jantan dan mempunyai sifat reversible. Tujuan penelitian adalah mengetahui pengaruh ekstrak secang (Caesalpinia sappan L) dengan jumlah spermatozoa pada mencit jantan (Mus musculluS L). Penelitian ini menggunakan metode True Eksperimental dengan randomized post test only control group design dengan sampel adalah 32 ekor mencit jantan. Perlakuan pada penelitian ini terdiri dari 2 faktor yaitu ekstrak secang yang terdiri dari kelompok kontrol, etanol, fraksi kloroform dan fraksi air. Faktor kedua adalah waktu pengamatan terdiri dari 10 hari setelah perlakuan untuk melihat jumlah spermatozoa dan 20 hari setelah perlakuan dihentikan untuk melihat jumlah spermatozoa. Penelitian dianalisis dengan uji ANOVA kemudian dilanjut dengan uji Tukey. Hasil penelitian menunjukkan ada perbedaan bermakna antara kelompok perlakuan dengan kelompok kontrol dengan p-value<0,05. Ekstrak secang juga berpengaruh terhadap jumlah spermatozoa.
HUBUNGAN POLA MAKAN, AKTIVITAS FISIK, DAN CITRA TUBUH DENGAN STATUS GIZI LEBIH PADA REMAJA PUTRI DI SMA NEGERI 3 TAMBUN SELATAN
Authors: Damayanti Erina Rizky
Published: February 2022

Masa remaja merupakan masa terjadinya perkembangan dan pertumbuhan dari aspek fisiologis, psikologis, dan sosial pada masa anak-anak menuju dewasa serta masa remaja rentan akan masalah gizi lebih karena adanya ketidakseimbangan antara asupan makan dan pengeluaran energi melalui aktivitas fisik. Ketidakpuasan akan citra tubuh menjadi perhatian khusus pada remaja putri untuk mengontrol berat badan. Penelitian ini bertujuan untuk mengetahui hubungan antara pola makan, aktivitas fisik, dan citra tubuh dengan status gizi lebih pada remaja putri di SMAN 3 Tambun Selatan. Penelitian menggunakan desain cross sectional dengan metode uji chi-square. Penilaian pola makan dilakukan menggunakan SQ-FFQ, aktivitas fisik dilakukan menggunakan PAL dan citra tubuh dilakukan menggunakan BSQ-16 serta pengukuran antropometri meliputi berat badan dan tinggi badan kepada 58 remaja putri. Hasil analisis menunjukkan bahwa pola makan (p=0,014), aktivitas fisik (p=0,023), dan citra tubuh (p=0,000) memiliki hubungan terhadap status gizi lebih remaja putri (p<0,05). Hal ini menunjukkan bahwa ada hubungan antara pola makan, aktivitas fisik, dan citra tubuh dengan status gizi lebih pada remaja putri SMAN 3 Tambun Selatan.

 

Kata Kunci : Remaja Putri, Pola Makan, Aktivitas Fisik, Citra Tubuh, Status Gizi Lebih.
HUBUNGAN POLA MAKAN, AKTIVITAS FISIK DAN INTENSITAS PENGGUNAAN MEDIA SOSIAL DENGAN STATUS GIZI LEBIH PADA REMAJA DI SMA NEGERI 14 JAKARTA TIMUR
Authors: Azzahra Afifah
Published: February 2022

Penelitian ini bertujuan untuk mengetahui hubungan antara pola makan, aktivitas fisik dan intensitas penggunaan media sosial dengan status gizi lebih pada remaja di SMAN 14 Jakarta Timur. Penelitian ini menggunakan desain cross sectional dengan metode uji chi square. Penilaian pola makan menggunakan SQ-FFQ, aktivitas fisik menggunakan PAL, intensitas penggunaan media sosial menggunakan SONTUS serta pengukuran antropometri meliputi berat badan dan tinggi badan terhadap 58 remaja. Hasil analisis menunjukkan bahwa pola makan (p=0,014), aktivitas fisik (p=0,023) dan intensitas penggunaan media sosial (p=0,000) memiliki hubungan terhadap status gizi lebih pada remaja (p<0,05). Hal ini menunjukkan bahwa ada hubungan antara pola makan, aktivitas fisik dan intensitas penggunaan media sosial dengan status gizi lebih pada remaja di SMAN 14 Jakarta Timur.
Willem Bart de Lint (2021) Blurring Intelligence Crime: A Critical Forensics. Singapore: Springer
Authors: Hughes David A.
Published: February 2022

David Hughes reviews Blurring Intelligence Crime: A Critical Forensics
Young coconut juice increased number of calbindin and vitamin D receptor cells via estrogen receptors in gastrointestinal tract of orchidectomized rats
Authors: Hayeelateh Mareeyae , Hutapea Albert M , Radenahmad Nisaudah
Published: February 2022

Adult male rats were orchidectomized, and their gastrointestinal tract was stained immunohistochemically with specific antibodies against calbindin (CB), a calcium-binding protein and vitamin D receptor (VDR), two essential factors in calcium absorption and bone formation. Compared to normal rats, the number of CB-immunoreactive and VDR-immunoreactive cells in the gastrointestinal tract were significantly reduced in orchidectomized rats, but was restored to normal by injecting these rats with estradiol benzoate or by feeding with young coconut juice (YCJ), which was found to be not dose-related. In an attempt to find out if the osteoporosis-protective effects of YCJ were due to the binding of the YCJ active component(s) with estrogen receptors, ERα and ERβ, anti-ERα and ERβ were detected immunohistochemically, and a significant correlation was detected between CB-/VDR-reactive cells vs. ERα-/ERβ-reactive cells. Immunohistochemical profiles showed significant correlations between CB-/VDR-immunoreactive cells vs. ERα-/ERβ-immunoreactive cells. The results suggest that YCJ may be as effective as estradiol benzoate in reducing osteoporosis, probably as a selective estrogen receptor moderator.
Neuroprotective effect of beta-D-glucan polysaccharide on hyperglycaemia-induced cerebral injury in diabetic animal model
Authors: Agbor C A , Fischer C E , Agaba E A , Nnenna W A
Published: February 2022

An edible mushroom, Aricularia polytricha is used by local Nigerians in managing diabetes-related complications including infertility and diabetic neuropathy, but this age-long practice has been going on without the corresponding clinical trial and acceptable experimentation. β-D-Glucan polysaccharide is a bioactive fractionate of Auricularia polytricha, an edible mushroom with nutritional and therapeutic property. This study was intended to investigate the neuroprotective effect of β-D-Glucan polysaccharide on hyperglycaemia-induced cerebral injury in diabetic Wistar rats. Experimental animals were grouped into four: Group A served as normal control and was placed on distilled water, while groups B, C and D were induced with diabetes using 65 mg/kg bw of streptozotocin (STZ). Diabetic animals in Groups C and D were treated with 120 mg/kg bw and 200 mg/kg bw of β-D-Glucan polysaccharide respectively. Group B served as diabetic control animals. An analysis of oxidative stress markers (superoxide dismutase, catalase and melondialdehyde) was done to estimate serum levels of the markers; histopathological examination was done to determine micro-structural alteration of brain cells; cell quantification was also done to assess the degree of hypertrophy and proliferation of neurons. Statistical analysis was carried out using Analysis of Variance at p<0.05. Results showed that hyperglycaemic ambience induced a significant increase in serum level of oxidative stress markers with a concomitant increase in cell count, volume and mean size. Increase in glial cells aggregation in the cerebral cortex are indicators of cerebral damage in diabetic control animals. However, levels of oxidative stress markers were significantly downgraded following β-D-Glucan polysaccharide administration. Glial cell aggregation and inflammatory infiltrates were also decreased in diabetic models placed on β-D-Glucan polysaccharide when compared to diabetic control animals, indicating reversal in cerebral damage. The present study suggests that β-D-Glucan polysaccharide has neuroprotective effect in diabetes-induced cerebral damage in Wistar rat.
Acute Neurological Brain Lesions in the Structure of the Clinical Picture of Severe Respiratory Syndrome-2 (SARS-CoV-2)
Authors: Dorovskikh G. N. , Sedelnikov S. S. , Kozhedub S. A. , Sulim D. A. , Biler Ya. A. , Podenkova A. A.
Published: February 2022

The coronavirus of severe acute respiratory syndrome-2 (SARS-CoV-2) and the coronavirus infection caused by it, along with damage to the respiratory system, can lead to disorders of the central and peripheral nervous system. The article presents literature data and own observations of neurological disorders in patients with coronavirus disease in the superacute period. Pronounced neurological disorders are mainly observed in severe coronavirus disease and include acute ischemic stroke, subcortical microand macro— bleeding, acute necrotizing encephalopathy, Guillain-Barre syndrome. Factors potentially complicating the course of coronavirus disease and contributing to the development of neurological complications are hypertension, diabetes mellitus, chronic diseases of the heart and respiratory system. Based on existing publications and our own observations, we have systematized information about the relationship between coronavirus disease and neurological disorders, about possible factors contributing to the occurrence of stroke. The possibilities of using chest MSCT as the only method of radiation diagnostics for the early detection of viral pneumonia in patients receiving emergency and emergency care at the regional vascular center of BUZOO «GC BSMP No. 1» are considered. The use of this method, in the ultra-acute period of acute ischemic stroke, during the first 40 minutes from the moment of admission, can significantly reduce the time of diagnosis and mortality in patients with acute ischemic stroke and viral pneumonia.
Diagnosis of Spinal Metameric Arteriovenous Malformation Syndrome (Case Report)
Authors: Rasulova E. V. , Pronin I. N. , Afandiev R. M. , Zakharova N. E.
Published: February 2022

This paper presents a rare case of spinal arteriovenous metameric syndrome (SAVMS) with lesions localized in the lower thoracic spine with the presence of two closely spaced arteriovenous malformations intramedullary and extradural (intravertebral) localization. The possibilities of minimally invasive contrast dynamic MR-angiography (TRICKS) in the diagnosis of the main components of vascular malformations and in determining the level of their arterial blood supply have been demonstrated.
A Necessity of Minimum Distance among Businesses in the Beauty Industry
Authors: Kim Sin-Mi , Na Myung-Suk
Published: February 2022

Recently, there has been a shift in beauty market from beauty salon-led market where demand was higher than supply to customer-driven market when demand is lower than supply. At present, beauty salons are already saturated. Under excessive competitions, furthermore, profitability has significantly decreased. Despite high competitiveness and great ripple effects, however, domestic beauty industry is undergoing some difficulties due to industry polarization and absence of a decent system. Considering a necessity of protecting right to life and goodwill for beauty businesses and establishing the ground for co-prosperity, therefore, this study targeted to minimize damages resulting from business overlapping and find a way for co-prosperity through a questionnaire survey on the awareness of model transactions against franchise chain and mom-and-pop beauty salon managers, and the results found the followings: According to detailed analysis on the current situations of beauty industry, 91.7% said that supply is now greater than demand. In addition, 80.6% understood a necessity of adopting minimum distance among businesses in beauty industry because of decrease in sales and difficulties in recruitment difficulties. Therefore, this study aimed to suggest such necessity and improve value orientation in beauty industry.
نظرة في منهج الأصوليين في مقاصد الشريعة الإسلامية من جهة أنواعها
Authors: عثمان ميرغني علي بلال
Published: February 2022

نظرة في منهج الأصوليين في مقاصد الشريعة الإسلامية من جهة أنواعها

يتناول هذا البحث قضية من قضايا تتعلق بأنواع مقاصد الشريعة الإسلامية من جهة أنواعها و بيان اختلاف العلماء في عدها خمسة أو ستة، و قد ذكرت أن علماء الأصول اهتموا بالمقاصد قديما و حديثا و تعددت أبحاثهم بالمفيد الناجح، و قد أوضحت ذلك بذكر حلقات سابقة من علماء الأصول القدامى و المحدثين، و قد أبنت منهج من ذهب إلى عدها خمسة و هم المتقدمون غالبا و من ذهب إلى عدها ستة و عشرون و هم المتأخرون غالبا.

و بالإطلاع على آراء الفريقين اتضح لي أن المتقدين عدوها خمسة إذ أنهم باستقرائهم و واقعهم وجدوها شاملة و وافية في عهدهم، أما الآن فبالإستقراء و التتبع و معرفة الواقع لزمنا أن نعتبرها ستة و ذلك ما تؤيده الأدلة في اللغة و الشرع و الواقع و ما استجد في حياة الناس من وسائل العصر، لا سيما و أن العرض يفدى بما اتفق عليه من الأمور الضرورية كالنفس و المال، و أن العرض يفقد الصيانة إذا هتك و إن لم يحصل نسل مما يدل على اقترافهما و تغايرهما.
Peningkatan Kinerja UMKM dalam Kluster Kue Kering di Kabupaten Cianjur
Authors: Sitanggang Agnes Liana Monika , Joycelyn Benedicta , Febrian Brilyan , Tanaka Christian , Santiago Elena Setiani , Devina Felicia , Christian Kosasih Hosea , Budi Kusuma Liem Kevin , Elfriede Dwining Putri
Published: February 2022

Usaha mikro, kecil, dan menengah memiliki kontribusi yang besar dalam menggerakkan roda perekonomian Indonesia. Hal ini disebabkan karena jenis usaha ini berperan dalam perluasan lapangan pekerjaan dan penurunan angka pengangguran. Sehingga itu, pemerintah pusat dan daerah mengeluarkan berbagai stimulus untuk mendorong pertumbuhan usaha ini. Di Kabupaten Cianjur, salah satu industri yang memiliki potensi dan peluang yang besar untuk berkembang adalah industri makanan, seperti usaha kue kering. Namun, pengembangan ini dibatasi oleh tantangan yang dialami oleh usaha mikro, kecil, dan menengah, secara khusus di dalam manajemen bisnis. Oleh karena itu, penelitian ini memiliki tujuan untuk permasalahan-permasalahan yang dialami oleh salah satu usaha mikro dalam industri kue kering di Cianjur, beserta dengan strategi yang tepat untuk menanggulanginya dengan menggunakan pendekatan The House Model. Hasil yang didapatkan menunjukkan bahwa kendala dari Senada Cookies berasal dari aspek strategik yang belum terdefinisi dengan baik. Selain itu, usaha memiliki permasalahan di dalam berbagai aspek manajemen bisnis, seperti operasional, purchasing, pemasaran, dan keuangan. Melalui The House Model, strategi utama dalam peningkatan kinerja adalah untuk melakukan pengembangan dalam aspek strategik dengan memperjelas visi, misi, tujuan, dan rencana usaha. Kinerja dari aspek manajemen bisnis lainnya akan mengalami peningkatan sejalan dengan kejelasan dari aspek strategik.
Analisis Forecasting Harga Saham Perbankan Blue Chip Periode Maret 2019 – Maret 2021 Menggunakan Model ARCH-GARCH
Authors: Manurung Adler Haymans , Simatupang Apriani , Puspitasari Veny Anindya
Published: February 2022

Pengambilan keputusan pembelian dan penjualan saham dilakukan beberapa analisis. Salah satu analisis yang digunakan sebelum membeli atau menjual saham adalah forecasting (peramalan). Penelitian ini bertujuan untuk melakukan peramalan harga saham perbankan yang termasuk ke dalam saham-saham bluechip dengan menggunakan model ARCH-GARCH. Metode analisis yang digunakan adalah metode analisis deskriptif kuantitatif. Analisis deskriptif kuantitatif digunakan untuk menggambarkan hasil perhitungan forecasting yang dilakukan. Saham perbankan blue chip yang dimaksud terdiri dari saham BBCA, BBNI, BBRI dan BMRI. Penelitian ini mengungkapkan ramalan saham pilihan jika terjadi fenomena anomali pasar dalam hal ini pandemic covid 19 di hari Rabu. Hasil analisis penelitian menunjukkan bahwa berdasarkan standar deviasi, investor risk averse lebih sesuai memilih BBRI sedangkan investor risk taker lebih sesuai memilih BBCA. Berdasarkan perhitungan RMSE, MAE dan MAPE, maka saham BBRI dan BMRI dapat menjadi saham pilihan karena risikonya lebih rendah selain itu berdasarkan hasil analisis forecasting yang dilakukan harga penutupan saham BBRI memiliki kenaikan yang lebih tinggi dibandingkan saham perbakan bluechip lainnya.
Kompromi Rasionalitas Pemikiran Ekonomi Koperasi dan Ekonomi Syariah
Authors: Fathoni Abdullah
Published: February 2022

Latar belakang berdirinya setiap negara di dunia ini berbeda-beda, perbedaan tata nilai, perbedaan sumber daya alam dan lain-lain. Untuk itu pendekatan yang digunakan guna mengelaborasi setiap masalahnya juga berbeda, dan setiap negara mempunyai caranya sendiri dalam merespon globalisasi ekonomi. Kompromi rasionalitas pemikiran ekonomi koperasi dan ekonomi syariah adalah salah satu cara untuk mencari titik keseimbangan baru antara kearifan lokal, cita-cita nasional dan tata nilai bangsa Indonesia dalam merespon globalisasi ekonomi. Ada dua pendekatan yang digunakan dalam tulisan ini, yaitu field study dan librarian study. Sistematika yang digunakan dalam penulisan adalah, Pertama; merumuskan kajian secara akademis tentang problematika seputaran pembangunan ekonomi bangsa Indonesia dan merumuskan tantangan ekonomi kontemporer, Kedua; hasil rumusan tersebut menjadi bahan diskusi di kampus pada kelas strata sarjana dan pascasarjana, Ketiga; hasil diskusi di kampus dijadikan bahan untuk pembicaraan dan kajian dengan para pakar ekonomi koperasi dan ekonomi syariah. Dari hasil kajian tersebut di atas dapat disimpulkan bahwa bangsa Indonesia harus merumuskan tersendiri langkah-langkah kedepan guna menghadapi era globalisasi ekonomi yang berdasarkan jati diri bangsa sendiri sebagaimana dirumuskan pada nilai-nilai yang terkandung didalam Pancasila dan pasal 33 UUD 1945.
SUVREMENO SHVAĆANJE DJETETA UNUTAR INSTITUCIJSKOG KONTEKSTA U HRVATSKOJ
Authors: Klišanić Anamarija , Vrsalović Nardelli Ines
Published: February 2022

Suvremena shvaćanja djeteta te uviđanje važnosti holističkog pristupa u cilju postizanja njegove maksimalne dobrobiti u području razvoja i učenja potaknula su na promišljanje teoretičare i praktičare. Pod utjecajem Nove paradigme djetinjstva, koja dijete vidi kao kreatora vlastitog odgojno-obrazovnog procesa, te u sinergiji teoretičara i praktičara iz područja odgoja i obrazovanja u Republici Hrvatskoj nastaje Nacionalni kurikulum za rani i predškolski odgoj i obrazovanje (2015). Za razliku od tradicionalnog shvaćanja djeteta i djetinjstva, usmjerenog više na produkt učenja negoli na njegov proces, suvremen pristup djetetu uvažava dijete kao kreatora vlastitog odgojno-obrazovnog procesa, uz zadovoljavanje sociopedagoške, prostorne i vremenske dimenzije koje se stalno isprepliću unutar institucijskog konteksta. Razumijevanje suvremenog kurikuluma koje djetetu prilazi na potpuno nov način podrazumijeva zajedničko učenje djece i odraslih u humanističkom i sociokonstruktivističkom okruženju. Odmicanje od tradicionalnog shvaćanja djeteta i djetinjstva, u kojem se na njega gleda kao na prazno platno koje u institucionalnom kontekstu tek treba ispuniti, kao i prihvaćanje suvremenih spoznaja osvijestilo je važnost preispitivanja osobnih pedagogija praktičara. Takođe, potaknulo ih je na cjeloživotno obrazovanje te osvijestilo potrebu razvoja kulture vrtića koja se očituje u kvaliteti odnosa svih odraslih osoba i djece koji su uključeni u odgojno-obrazovni proces.
Os benefícios da massagem terapêutica na gravidez e trabalho de parto
Authors: Tralhão Filipa , Carteiro Dora
Published: February 2022

A gravidez e o trabalho de parto implicam adaptações e desconfortos tais como a presença de alguma dor. A promoção do conforto ao longo do ciclo gravídico e trabalho de parto passa pelo controlo da dor e é determinante para uma vivência positiva atual e em futuros projetos de maternidade. A utilização da massagem terapêutica deve ser valorizada nos cuidados à grávida/casal.

Objetivo: Identificar os benefícios da massagem terapêutica na gravidez e trabalho de parto.

Método: Revisão sistemática da literatura, utilizando o método PI[C]OD, foi definida como questão: “Quais os benefícios da massagem terapêutica durante a gravidez e trabalho de parto?”. A pesquisa foi realizada com os descritores massage, therapy, pregnant woman.

Resultados: Foram selecionados 11 artigos que analisam a utilização da massagem terapêutica como intervenção eficaz na gravidez e trabalho de parto. A evidência mostra os benefícios desta no alívio dos desconfortos da gravidez e na redução da dor e da duração do trabalho de parto.

Conclusão: A massagem é uma técnica de relaxamento que apresenta benefícios para a díade: grávida-feto. A inclusão desta intervenção na prática de cuidados durante a gravidez e trabalho de parto é pertinente, acessível, segura, autónoma e facilmente aceite pelas grávidas.

Palavras-chave: grávida; massagem; terapia; trabalho de parto
USE OF ARTIFICIAL INTELLIGENCE IN IN SILICO DRUG DISCOVERY OF PHARMACEUTICALS
Authors: Bhattacharyya Sayani , Ramakrishna Kavya H. ,   Department of Pharmaceutics, Krupanidhi College of Pharmacy, 12/1, Chikka Bellandur, Carmelaram Gunjur Road, Varthur Hobli, Off Sarjapur Road, Bengaluru - 560 035, Karnataka, India
Published: February 2022

Artificial intelligence, a machine-learning process, builds a smart machine that simulates the performance of the human brain and possesses the capability of utilizing a massive amount of data required to achieve a specific goal through learning and problem solving. The idea of artificial intelligence and deep learning turns out to be more useful in pharmaceutical drug development. In this review, we mainly discuss several applications of artificial intelligence including machine learning and deep learning in scientific drug discovery and development, rational drug design and identification of candidate molecules. In addition, we comment on the wide role of machine learning and artificial intelligence approaches to other aspects of drug development.
RNA BASED THERAPIES - A POSITIVE OUTCOME OF COVID-19
Authors:   Associate Editor,  Indian Drugs, Patani George
Published: February 2022

Dear Reader, It was way back in December 2014 that Ella Watson-Stryker was named TIMES Person of the Year for 2014 and featured on the Cover of Time Magazine. Dr Watson-Stryker was recognised with the honour, which she shared with all the healthcare workers who, under trying circumstances,helped people in various west African countries fight the Ebola virus. While many experts predicted that the Ebola virus might cause a pandemic like situation across the world, the efforts of the healthcare workers ensured that Ebola virus was contained. However, the COVID-19 pandemic nearly five years later created a similar desperate situation not just in a small region of the world but all across the globe. This desperate situation however, has facilitated the rapid development and acceptance of a new class of therapeutics called RNA based therapies.
ICT-Based Lajur Bata Game Media Using Guided Discovery Method on Flat-sided Space Geometry Subject
Authors: Rionanda Lucky Stiardi , Farida Farida , Putra Fredi Ganda , Damayanti Erfina , Pradana Kenny Candra
Published: February 2022

This study aims to develop an interactive medium based on ICT with the Guided Discovery method for the Lajur Bata game on the geometry of the flat side space. In this study using research and development procedures through ADDIE model with the following stages: 1) Analysis; 2) Design; 3) Development; 4) Implementation; 5) Evaluation. The Feasibility Test involved 3 Material Experts and 3 Media Experts, while the Attractiveness Test involved 10 students in the Small Scale Trial, and 26 students in the Large Scale Trial. Based on the results of the validation questionnaire, both material experts and media experts have met the "valid" criteria. In the student's response to the feasibility and attractiveness of the brick-line game media, the results of the small-scale student response questionnaire of El-Shihab Islamic Junior High School Bandar Lampung with the "Interesting" criteria. On a large scale, El-Shihab Islamic Junior High School Bandar Lampung with the "Very Interesting" criteria so that the product developed by the researcher is feasible to use.
“It Kind of Shows the Terrible Morality of This Scene”: Using Graphic Novels to Encourage Feminist Readings of Jewish Hebrew Texts with Religious Significance
Authors:   New York University, Hurwich Talia
Published: February 2022

This study considers whether and in what ways graphic novel adaptations of traditional Jewish Hebrew texts can encourage adolescent Modern Orthodox girls to adopt autonomous critical responses when encountering narratives that present women in unequal roles vis a vis men. According to scholars, Jewish literacy should teach students to read traditional Hebrew texts reverently while forming autonomous interpretations and opinions. Instead, Jewish educators teach normative readings posed by approved rabbinic authorities. This is particularly the case when teaching issues relating to gender among Modern Orthodox Jews, a conservative Jewish denomination, strives to synthesize tradition with the values of modern, secular society. I therefore explore through think-alouds and semi-structured interviews to explore graphic novel adaptations of Jewish texts’ potential to give adolescents opportunities to voice autonomous, critical interpretations. Findings show that adolescents, through graphic novel adaptations of traditional Jewish texts are able to engage in critical readings of the source material. Participants admitted that while they inherently imagined scenes to unfold in a certain way, they never spent time deeply considering the assumptions such imagined details led them to make. Thus, reading graphic novel adaptations did not lead participants to uniformly challenge their understood rabbinic metanarratives, but instead generally made them question their own personal imaged narratives.
Everybody Does It: The Pragmatics and Perceptions of International Chinese Graduate Students and their American Peers Regarding Gossip
Authors:   New York University Steinhardt, Ebsworth Miriam Eisenstein , Ebsworth Timothy John ,   Kean University, Cai Chencen Cai ,   Guangdong University of Foreign Studies
Published: February 2022

Integrating natural observation, interviews, and quantitative analysis, we used a mixed design to compare the socio-linguistic judgments of international Chinese students at a private University on the East Coast of the United States (US) with those of their native English-speaking peers regarding a critical incident involving gossip. Ninety-two participants evaluated alternative sociolinguistic strategies offered in addressing the incident on semantic differential scales. Judgments by each group regarding four alternative responses were surveyed and compared. Twenty participants, ten from each group, participated in semi-structured interviews. Themes were developed through a recursive process: interpretations were validated by a bilingual bicultural expert. Several distinctions in judgments emerged. The most preferred alternative to dealing with a group gossiping about a friend for Americans was to say honestly that it made them uncomfortable while Chinese participants preferred requesting a change in topic. Such contrasts were found to be representative of underlying sociocultural values for each group. Intercultural pragmatic distinctions such as these could lead to pragmatic failure and have the potential to interfere with the development of intercultural friendship among the members of the two groups. Implications for pedagogy and developing cross-cultural insight are offered.
Some effects of asymmetry of pressure Distribution in a cyclone field
Authors: RAJ Y. E. A.
Published: February 2022

When the isobars in a cyclone field are concentric circular, the isopleths of vorticity arc also obviously circular. An asymmetry In the pressure profile can be Justifiably expected to cause an asymmetry in the vorticity profile also. This aspect has been studied by making use of a general pressure model. It has been shown that the asymmetry of vorticity profile; of a cyclonic storm in its outer region is far less than that of the corresponding pressure profile. There upon it has been concluded that a cyclonic storm with markedly asymmetric isobars may not manifest the same degree of asymmetry in its rainfall distribution and in radar/satellite imageries.
Estimation of upper air relative humidity For objective analysis
Authors: KULKARNR P. L. , SINHA S. K. , TALWALKAR D. R. , NARKHEDKAR S.G. , NAIR S. , RAJAMANI S.
Published: February 2022

A multiple regression relation was developed between upper air relative humidity

and the related surface observations, like cloud cover, present weather and surface relative humidity etc. Using this regression relation at a number of surface observing stations the relative humidity values for upper air at 700 hPa west estimated from surface relative humidity, cloud cover and present weather for six days from 4 to 9 July 1979. In order to determine the impact of these estimated value, two sets of analyses were made using optimum interpolation scheme, one including estimated RH values and the second excluding them RMS errors were calculated for all the SIX cases, comparing with the observed radiosonde data to examine how both sets of analyses with and without estimated data fitted the observations. RMS errors were also computed comparing  with ECMWF-RH Analyses. Lastly, these analyst's were compared with satellite cloud pictures and found them  in close agreement with the observed data.
Wind power potential over Delhi
Authors: DUGGAL Y. M. , LAL BHUKAN , MEHRA H.C. , BHARTI R.
Published: February 2022

An attempt is made to investigate in the field of renewable source of wind energy available in nature by estimating the wind power potential over Delhi and it~ effective utilisation for windmills for different speed ranges. Frequency and wind speed fine spectral analysis indicates that windmills designed for upper light wind range. (6 to 8 km/hr) can be effectively put into operation during the daytime for about 8-12 hrs., the time depending upon the month and the range of the wind speed at which the windmill can be operated. The max power potential over Delhi varies from 720 watt hr/m2/day during the months of March to min. of 130 watt hr/m2/day in the month of November.
Some studies on rainfall climatology Of the Nagpur region
Authors: GHADEKAR S. R. , THAKARE K. K.
Published: February 2022

Characterisation of rainfall of the Nagpur region for crop production and cropping patterns is studied. Percentile , Index based on five parameters to show adequacy of rainfall for crop production is developed and round to describe monsoon performance satisfactorily, These studies have revealed that the mean rainfall of kharif season is 861.5 mm(CV20.8 %) with S2.3(CV) 7 .3 %) rainy days, Cropping season of 13weeks (25-37MW) with dependable rainfall at 75, 80, 85, 90% probability levels was round to be most assured and risk-free The cropping period at 75% and 50% probability levels can be extended up to 18 weeks (23-40MW) with marginal

risk, In rabi and summer growing seasons, there was no rainfall at all at any feasible, dependable level and this situation asked for Irrigation, Strategy for stabilizing rainfed crop yields Included the adaptation of short to medium duration crops (16-18 weeks) with water requirements 50~-900 mm, viz., groundnut, soybean, sunflower, maize, sorghum. Long duration crops like cotton and rice with high water requirements can be adapted with certain risk.
The diagnostic value of monocyte/high-density lipoprotein ratio (MHR) in patients with unstable angina pectoris
Authors: Çelik Kaan
Published: February 2022

Aim: The present study aimed to review the association of Monocyte/High-Density Lipoprotein (HDL) ratio (MHR) in patients with and without stenosis who had angiography due to preliminary diagnosis of unstable angina pectoris (USAP) and evaluate the diagnostic value of MHR for diagnosis of USAP with stenosis. (stenosis requiring intervention (≥50%) and stenosis not requiring intervention (
Комбинированный метод распознавания лица
Authors: Mukhamadiyeva L. , Moldagulova A.
Published: February 2022

Currently, face recognition is one of the most important achievements of biometrics, which al-lows using algorithms to determine the character of a person by his physiological characteristics. Research and analysis of existing methods for face recognition helps, to recognize the positive and negative aspects of each of the methods provided, on the basis of which an effective method of pattern recognition is created. The fundamental idea of this article is to improve the consolidated face recognition technique using the OpenCV specialized vision library and the Viola-Jones calculation, with the help of which a face from a video stream is correlated with certain 68 points of the face. Additionally, a calculation is considered to naturally alter the image difference in order to productively identify the structure of the face. In addition, in the work, it was possible to improve the quality of object recognition, reduce the degree of false confirmation, reduce the time for preparing the classifier and image processing.

В настоящее время распознавание лица -одно из важнейших достижений биометрии, которое позволяет с помощью алгоритмов определять характер человека по его физиологическим характеристикам. Исследование и анализ существующих методов для рас-познавания лиц помогаетраспознать положительные и отрицательные аспекты каждого из предоставленных методов, на основе чего создается эффективный метод распознавания об-разов. Фундаментальной идеей данной статьи является улучшение консолидированной тех-ники распознавания лиц с использованием библиотекиспециализированного зрения OpenCV и вычисления Виолы-Джонса, с помощью которого лицо из видео-потока соотносится с определенными 68 точками лица. Дополнительно рассматривается расчет для естественного изменения различия изображения, чтобы продуктивно идентифицировать структуру лица. Кроме того, в работе удалось повысить качество распознавания объектов, снизить степень ложного подтверждения, сократить время подготовки классификатора и обработки изобра-жения.
Development of a personal data module for the citizens' immigration system
Authors: Ускенбаева Р.К. , Бектемысова Г.У. , Керимбай Е.Т.
Published: February 2022

Рассматривается проблема внешней и внутренней иммиграции населения Республики Казахстан. Для этого разрабатывается интеллектуальная информационная система для анализа данных об иммиграцив реальном времени. На сегодняшний день разработанонесколько моделей.В данной статье рассматривается разработка модуля персональных данных для системы иммиграции граждан.

We are considering the problem of external and internal immigration of the population of the Republic of Kazakhstan. For this, we are developing an intelligent information system for analyzing immigration data in real time. To date, we have developed several models. This article discusses the development of a personal data module for the citizens' immigration system.
The role of smart technologies in the development of human capital and a modern approach to education
Authors: Кубеков Б.С. , Ускенбаева Р.К. , Науменко В.В.
Published: February 2022

Для развития образования уже требуется влияниечеловеческого капитала. Необходимо изменять саму образовательную среду, а не просто наращивать объѐмы образовательных ресурсов, должно качественно измениться само содержание образования, его методы, инструменты и среды, необходим переход к Smart-образованию. Необходимо развивать такие компетенции, как аналитические, навыки решения комплексных проблем, инновационность –способность к развитию новых идей и их внедрению, навыки межкультурных коммуникаций, а также проектный подход.

The development of education already requires the influence of human capital. It is necessary to change the educational environment itself, and not just to increase the volume of educational resources, the content of education itself, its methods, tools and environments must change qualitatively, a transition to Smart-education is necessary. It is necessary to develop such competencies as analytical skills, complex problem-solving skills, innovativeness -the ability to develop new ideas and their implementation, intercultural communication skills, as well as a project approach.
ИСТОЧНИК ИНФОРМАЦИИ И БОЛЬШИЕ ДАННЫЕ
Authors: Куандыков А.А. , Мырзаканов Д.У.
Published: February 2022

В этой статье освещены основные понятия больших данных и источники информации в логистике. Логистика является неотъемлемой частью транспортировки и складских помещений вплоть до интернет-магазинов. Краткая информация о логистике описывается в современных процессах логистики. Большие данные показывает область применения и популярность данного направления. Правильное использование источников информацииотражает корректное понимание как разбираться в любой области, анализируятехнологии, подходы, методы, алгоритмы и технологии разработки.
COMPETITIVE LEARNING IN NEURAL NETWORKS
Authors: Mukhanov S.B. , Aldanazar A.A. , Uatbayeva A.M. , Alimbekov A.Ye. , Marat G.S.
Published: February 2022

The article presents the basic concept of competitive learning in neural networks. Provides the main machine learning learning models and applications. The analysis of the advantages and disad-vantages of these models is carried out. The geometric interpretation of competitive learning is presented in terms ofmathematical formulas, as well as the behavior of neurons in this model. Neural systems are described as a powerful tool and driver in the field of modern Internet technologies, in data science and big (meta) data.
РАЗРАБОТКА СИСТЕМЫ ПИТАНИЯ, АЛГОРИТМА УПРАВЛЕНИЯ И АРХИТЕКТУРЫ ВЕРБАЛЬНОГО РОБОТА
Authors: Амиргалиев Е.Н. , Сундетов Т.Р. , Кунелбаев М.М. , Ибраимова А.А.
Published: February 2022

В данной статье рассмотрена разработка системы питания, алгоритма управле-ния и архитектуры вербального робота. Робот основан на общедоступном 3Dпечатном принтере. Вэтом исследовании была разработана архитектура общей программной системы вербального ро-бота, атакже усовершенствована система питания и алгоритм управления целой системы. С помощью оборудования JetsonTx1 и сенсорным экраном для взаимодействия с InМoovбыл сделан ин-терфейс для управления всей системы. Датчик Kinect играет главную роль в прогрессе изучения дан-ной темы. По сравнению с существующими гуманоидными роботами в вербальном роботе развита автоматизированная платформа, низкая стоимость и полностью функциональна.
Использование визуальной аналитики для разработки человеческих и машино-центрических моделей: обзор подходов и предлагаемых информационных технологий
Authors: Mukanova M.A. , Krak I.V. , Kuandykov A.A. , Sagalova A.S. , Baibatyrov D.A.
Published: February 2022

The use of a visual analytical system in machine learning is the basis for the integration of human and the use of his intellectual capabilities in the construction of models. At the same time, visual analytics is used to expand human knowledge and is used as a research tool. We investigate the forms and goals of using visual analytics workflow towards the formation of the final product. Workflow is divided into human oriented and machine-oriented in order to build a model as an information processor and decision-making mechanism. Models are built on the basis of the end user, which can be either a machine or a hu-man.The concepts of model building and the role of machines and humans in these processes are investigat-ed. A practical implementation of the classification information technology in the studied concept ‘using op-posite model’ in the machine-oriented visual analytics workflow for using the machine model is proposed. The basis for this model is a model formed and used by human. To classify data, human intellectual abilities are used. The boundaries of classes are determined by a human and then projected into a hyperspace of at-tributes with the formation of a classification model that the machine uses. Information technology allows the machine to use a model built for humans.
Improving Curriculum Organization In The Education System In School
Authors: Maulida Rosena
Published: February 2022

The world of education cannot be separated from the curriculum. The curriculum is one of the most important components of education. The curriculum can cover a broad scope and a narrow scope. The curriculum must be in accordance with the needs and demands that exist in society. The curriculum must also be able to adjust the components in it. In its implementation in an educational institution, the curriculum needs to be developed, in developing a curriculum it certainly cannot be done without references or guidelines. One of the curriculum developed must pay attention to curriculum organization. Organizing the curriculum is one aspect that needs to be considered so that curriculum development can meet all the needs and demands of students, educators, and also the community. This study uses the Library Research method by examining several data sources from books related to the organization and design of curriculum development. The conclusion of this study is that the organization acts as a method used to determine the selection and integration of various learning experiences organized by educational institutions in the curriculum development process. An organization is very necessary for the management process, namely the planning organization, the organization in the context of implementing the curriculum, and the organization in the context of curriculum evaluation.
Global Analysis of Three-Dimensional Shape Symmetry: Human Heads (Part I)
Authors: Tran Vi-Do , Dao Tien-Tuan , NGUYEN Tan-Nhu
Published: February 2022

Facial paralysis grading methods are mostly based on geometrical dissymmetry between left and right heads. Dissymmetry also appears even on healthy subjects. Consequently, this dissymmetry should be computed to distinguish with one on facial palsy patients. However, no studies have been quantitatively reported this characteristic. In the first part of our study, we tried to calculate this quantity by computing distance and volumetric differences between left and right heads. In particular, 329 head models were reconstructed from medical images of subjects with normal head geometries in neutral mimics. These heads were then automatically cut into left and right regions. Then, Hausdorff distances between left heads and mirrored right heads were computed. Moreover, volumetric differences between left head convex hulls and mirrored right head convex hulls were also calculated. As a result, the dissymmetry values (Mean ± SD) in mean Hausdorff distances are 1.8243 ± 0.7029 mm, and ones in volumetric are 78.1254 ± 65.7040 cm3. In perspective, in the second part of our study, we will try to analyze geometrical symmetry on human skulls. Moreover, shape symmetry will be analyzed in more detail with different local shape topologies in different facial mimics. These analyses will finally be implemented on our clinical decision-support system for facial mimic rehabilitation.
Adhesive Strength of Hexadecane on Different Iron Compounds: an MD Approach
Authors: Ta Dinh Hien
Published: February 2022

The lubricity of alkane is a research target for numerous tribological applications in either industrial area or fundamental scientific studies. In the current work, a comparative investigation using a classical molecular dynamics (MD) method is carried out to investigate the effect of pure iron and its oxide surfaces on structural properties, adsorption ability of hexadecane (C16H34). A reliable force field (FF) of condensed-phase optimized molecular potentials for atomistic simulation studies (COMPASS) is employed to describe the intra- and intermolecular interactions for hexadecane and its interaction with iron oxide surfaces, while the interaction between hexadecane and pure iron is derived from an ab initio result. Regarding the surfaces, the pure iron surfaces are considered using embedded-atom method/Finnis-Sinclair potential (EAM/FS), while the iron oxide surfaces are constructed using the traditional Buckingham force field. The results reveal that hexadecane shows preferential adsorption on iron oxide surfaces compared to pure iron.