bluuebunny/crossref_metadata_2025 huggingface dataset:
Biological Therapies for Pediatric Atopic Dermatitis - A Review
Authors: Milano Giulia , Forestieri Stefano , Tedeschi Micol , Licari Amelia , Brazzelli Valeria , Marseglia Gian Luigi
Published: September 2023

Atopic dermatitis (AD) is the most frequent chronic-recurrent inflammatory skin disease
in the pediatric age. It has a complex and multifactorial pathogenesis: the two key actors are im-
paired skin barrier function and immune system dysregulation, which represent the main targets of
AD therapy. Monoclonal antibodies have revolutionized the management of moderate-to-severe
AD, by selective inhibition of key cytokines in the pathogenetic process. For this reason, there is
great interest in exploring AD pathogenetic mechanisms to develop new therapeutic strategies.
This review aims to summarize the most recent scientific evidence on available and future biologi-
cal therapies for the treatment of pediatric AD, emphasizing the molecular mechanisms underlying
their action.
Short-term SARS-CoV-2 Re-infection Rate in Vaccinated Health Workers
based on Received Vaccines: A Cross-sectional Study
Authors: Sinaei Reza , Jafari Maedeh , Karamozian Rezvan , Pezeshki Sara , Sinaei Roya , Robati Fatemeh Karami , Yeganeh Mehrnoush Hassas , Najafzadeh Mohammad Javad
Published: September 2023

Background:

Vaccines during the Coronavirus disease 2019 (COVID-19) pandemic entered
the market faster than a routine proportionate evaluation cycle. The highest number of deaths
and morbidities, especially by the type of B.1.617.2 (Delta) variant, is one of the reasons for this inevitability.
Accordingly, evaluation of the effects of vaccines is of great importance

Methods:

In this cross-sectional study, we investigated the effects of four current COVID-19
vaccines, such as AstraZeneca, Sputnik, Sinopharm, and Bharat, and the prevalence of COVID-19
occurrence among 600 vaccinated healthcare workers (HCWs) in the Southeast of Iran.

Results:

The incidence of infection among vaccinated HCWs was 36.3%, without any age and gender
difference, statistically. The infection rate with severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) following immunization with AstraZeneca, Sputnik V, Bharat, and
Sinopharm vaccines were 45.8%, 41.3%, 36.9%, and 18.6%, respectively (P.V=0.001). Those who
had a history of previous SARS-CoV-2 infection were more affected again despite vaccination
(P.V=0.001). However, out of 218 infected patients, only six patients (2.8%) were hospitalized,
while 26 patients (11.9%) received remdesivir and two patients (0.9%) needed to additional target
therapy with Iinterleukin-6 inhibitor of Tocilizumab due to cytokine storm.

Conclusion:

During B.1.617.2 circulating variant, all vaccines after a complete vaccination schedule
were relatively associated with protection against severe infection and hospitalization. We
found that people who received the Sinopharm vaccine had the lowest incidence of COVID-19
(18.7%), followed by Bharat. The lowest incidence of protection occurred with viral vector-based
vaccines, especially AstraZeneca.
The Impact of Acute COVID-19 Infection on Sleep Disorders: A Real-life
Descriptive Study during the Outbreak of COVID-19 Pandemic in
Vietnam
Authors: Duong-Quy Sy , Nguyen-Van Toi , Nguyen-Tuan Anh , Tang-Thi-Thao Tram , Nguyen-Hoang Quan , Tran-Van Huong , Vo-Thi-Kim Anh
Published: September 2023

Background:

Sleep has an essential role in restoring brain activity and balancing physiological,
immune, and metabolic factors in the body. Individuals, after being infected with
COVID-19, have been reported to have quite a lot of symptoms related to sleep disorders, so we
conducted this study to evaluate sleep disorders in patients with COVID-19.

Methods:

This study involved a cross-sectional design; 547 patients hospitalised due to COVID-19
and aged 18 years and above were included. The study used the questionnaire designed by the Vietnam
Society of Sleep Medicine (VSSM). Collected data were statistically analyzed and results
have been obtained using SPSS software version 22.0.

Results:

Nightmares have been found to be increased by 10.1%, sleep quality decreased by 51.2%,
and insomnia increased by 19%, compared to pre-infection. There were 24% of participants with
daytime sleepiness syndrome, 23% with symptoms of memory impairment, 17% with unexplained
anxiety and frustration, and 10% with loud snoring. In addition, the manifestations of sleep disorders
also became more and more severe than before the infection. 68.4% of subjects were not satisfied
with their current sleeping, 29.1% had sleep difficulties, including maintaining sleep, and
19.4% had trouble falling asleep.

Conclusion:

Sleep disturbance is a critical and common medical condition in COVID-19 patients.
It is necessary to have appropriate treatment measures for insomnia in COVID-19 patients to help
improve their health status and avoid post-COVID-19 sequelae.
Guavira Fruit Pomace Promotes Immunomodulation and Reduction of
Tumor Growth in Walker 256 Tumor-Bearing Rats
Authors: Zulin Natália Eirão , Martins Carolina Garcia , Appel Márcia Helena , da Silva Coutinho Débora Salles , Bialli Amanda Plaça , Bronoski Daiana Milena , Carvalhal Stephanie Rubianne Silva , dos Santos Elisvania Freitas , Loubet Filho Paulo Sérgio , Bonatto Sandro José Ribeiro , Fernandes Luiz Cláudio , Cordeiro Lucimara Mach Côrtes , Iagher Fabíola
Published: September 2023

Background:

Guavira fruit is widely used for juice extraction purposes, and this process
generates large amounts of pomace (waste). Guavira pomace was dried and milled to produce
guavira pomace flour (GPF), which is rich in antioxidants and dietary fibers (polysaccharides). These
compounds are known for their immunomodulatory and antitumor effects.

Objective:

To investigate whether GPF intake promotes immunomodulation and reduces Walker
256 tumor growth in rats.

Methods:

GPF was provided to Wistar rats in two different models: 1) 15-day Model, according to
which, Walker 256 tumor-bearing rats received GPF (63 mg/200 g b.w./day) simultaneously to tumor
growth for 15 days; 2) 45-day Model, according to which, tumor-bearing rats received GPF
for 30 days before tumor cell implantation, as well as during tumor growth - it totaled 45 days. After
animals were euthanized, tumors were collected and weighed, and tumor cells were isolated for
proliferation capacity determination ex vivo. Enzymatic/colorimetric methods were used to determine
resident peritoneal macrophages’ functionality, whereas blood T and B lymphocytes were assayed
for proliferation capacity, ex vivo, under stimuli.

Results:

The 15-day Model did not show tumor mass or cell proliferation reduction in the treated
group. GPF stimulated macrophage response in tumor-bearing and non-tumor-bearing rats. However,
there was a substantial reduction in tumor mass and tumor cell proliferation under the 45-day
Model. Macrophage and lymphocyte response decreased; it suggested that GPF can directly act in
the tumor.

Conclusion:

Based on these findings, GPF has immunomodulatory and antitumor actions, and ingestion
time plays a key role in them.
Immunological Evaluation of Pediatric Patients with Polyautoimmunity
Authors: Mahdavi Fatemeh Sadat , Tavakol Marzieh , Aghamahdi Fatemeh , Sadri Homa , Chavoshzadeh Zahra , Jamee Mahnaz , Noorian Shahab , Alaei Mohammad Reza , Ashkevari Pooya , Anaya Juan-Manuel , Abolhassani Hassan , Ochs Hans D , Azizi Gholamreza
Published: September 2023

Background:

Autoimmunity can be the first or predominant manifestation in patients with primary
immunodeficiency disorder, also known as inborn errors of immunity (IEI). This study aims to evaluate
the immune status of pediatric patients with polyautoimmunity to identify those with underlying immune
defects.

Methods:

In this cross-sectional study, pediatric patients with polyautoimmunity including at least one
confirmed autoimmune endocrine disease were enrolled. Demographic and clinical data were collected
using a questionnaire based on medical records and direct family interviews. For each patient, a basic immunologic
evaluation was performed. The clinical diagnosis was established according to the criteria of the
European Society for Immunodeficiencies (ESID). Based on the presence or absence of a history of severe
and/or recurrent infections, patients were divided into two groups for comparison.

Results:

Thirty-nine patients, 18 males (46.2%) and 21 females (53.8%), were included. Fourteen patients
(35.9%) had consanguineous parents. Fifteen patients (38.5%) had a history of severe and/or recurrent infections.
The median (interquartile range: IQR) age of our patients at the time of evaluation was 11.1 (9-16)
years. The median (IQR) age at the onset of infections and autoimmunities were 3 (1-10.8) and 5 (2.6-8)
years, respectively. The most common infectious complications reported were pneumonia and candidiasis,
each in 12.8% of the patients. The most prevalent autoimmune disorders were type 1 diabetes (74.3%) and
autoimmune thyroiditis (58.9%). IEI was diagnosed in six patients (15.38%), five of which were from the
group with severe or recurrent infections: three with selective IgA deficiency, two with common variable
immunodeficiency (CVID), and one with immune dysregulation, polyendocrinopathy, enteropathy, Xlinked
(IPEX), but without a history of infections.

Conclusion:

The occurrence of early onset polyautoimmunity in association with severe and/or recurrent
infections or in patients with a positive family history should be a warning sign for physicians to initiate an
evaluation for possible immunodeficiency disorders to prevent complications through early treatment.
Review of Development and Application of Main Micro-hydraulic Components and Key Technologies
Authors: Jianying Li , Guodong Qu , Shuai Xie , Chen Peng
Published: September 2023

:

Micro-hydraulic components and key technologies are important directions of fluid
transmission and control, which are widely used in the national defense industry, production line
conveying equipment, exoskeleton robot, and more.

:

The current development status of miniature hydraulic components and key technologies is summarized,
and the existing advantages of hydraulic components and technology are pointed out, and the
research object is focused on relevant papers and patents.

:

We study the beneficial effects of the existing microcomponents and technologies, the performance
indexes of typical products, and the latest progress in their structure innovation, material replacement,
testing methods, and processing technology are summarized.

:

Typical achievements, core components, and manufacturing aspects are studied in-depth. They become
smaller with increased output power and find more diverse scenarios with advancing technology
maturity.

:

By improving the hardware structure of the existing miniature hydraulic component, and constantly
innovating the processing technology, miniature hydraulic components will improve their efficiency
and power density and will focus on further miniaturization in the future.
A Model to Validate Different Inflections of Assamese Verbs
Authors: Sarma Parismita , Bhuyan Manash Pratim , Kalita Chandamita , Upadhyaya Varsha
Published: September 2023

:

A verb in a sentence defines the action to be performed and keeps the subject of the sentence in motion. Assamese is a language spoken by millions of people in Assam, a North Eastern state of India. In the Assamese language, different inflections of verbs express the tense of the action, whether it is present, past or future. Verbs are inflected according to person, number, gender, tense, and voice, thus showing their existence in different situations. In this research work, we have built a tool to check whether an Assamese verb form is valid or invalid. After checking the validity, it also displays the meaning of the inflected form of the root verb in English. The root verbs are conjugated with the inflectional morphemes, and inflected verb forms are recorded.

Background:

This work is completely new and done by the authors for the Assamese language. To build this tool, a few research papers on this language were studied, and a summary of them is written in the Related Work section.

Methods:

In this experiment, 72 root verbs and 132 inflections were used. GUI was designed by using Tkinter in Python. The inflected verb form passed through three modules consisting of different searching techniques. Assamese corpus, Google search, Assamese Wikipedia, and Manual evaluation, respectively.

Result:

Finally, 662 Assamese valid verb forms were found that have meaning and are used in a different context. Corpus search, Google search, Assamese Wikipedia and Manual Evaluation gave 232, 733, 550 and 112 numbers of overall search results accordingly.

Novelty:

This paper presents a novel validation framework for Assamese language verb inflections, which could help the linguistic community better comprehend verb inflection patterns and linguistic diversity. The manuscript explores the inflections of a lesser-known low-resource language that would be beneficial. This study could be considered as innovative and important because it has applications in areas like speech recognition, machine translation, and natural language processing.

Social Implication:

The linguistic community would benefit greatly from the creation of a new, freely accessible, user-friendly interface intended exclusively for validating Assamese verb inflections. The approaches used here to recognize correct inflections of Assamese verbs have been performed with in-depth analysis. The approach could have implications for language learning and education, improving machine translation and natural language processing systems. Validating the verb inflections may help in raising the awareness and recognition of research focused on underdeveloped or marginalized languages. As a result, speakers of these languages might have more equitable access to information, resources, and opportunities, thus resulting in a decrease in linguistic prejudice.
Management of Hepatocellular Carcinoma: The East-West Difference
Authors: Feng Maple Ye , Chan Stephen L.
Published: September 2023

Hepatocellular carcinoma (HCC) is highly prevalent, which contributes to the high disease
burden worldwide. It was recognized as the sixth most common cancer and the fourth leading
cause of mortality in cancer patients in the Global Cancer Statistics 2018. The management of HCC
between eastern and western countries varies from region to region due to the different epidemiology
of HCC and the approach of clinicians. Over the past decades, the multidisciplinary team approach
has taken a leading role in the therapeutic paradigm of HCC, and the main treatment options
include, but are not limited to 1) surgical resection; 2) transarterial chemoembolization (TACE); and
3) systemic therapies. Among these, surgical resection and TACE are applicable in earlyintermediate
stage HCC with curative intent, while systemic therapies are mostly applied to advanced
unresectable HCC. An individualized approach should be encouraged and tailored for each
patient, taking into account the different patient population, staging, and treatment responses to
achieve the best efficacy. This review discusses current advances and compares the eastern and
western treatment options in the management of HCC.
Urtica dioica (Stinging Nettle): A Comprehensive & Concise Review on its
Nutritional Profile and Therapeutic Applications
Authors: Aziz Namra , Vinod Yadav Rupali , Sarkar Dhrubajyoti , Wal Ankita , Verma Vaibhav , Wal Pranay
Published: September 2023

Background:

A relatively untapped origin of drugs is medicinal plants. Traditional medicine employs Urtica dioica L. to treat a variety of ailments. A plant that produces fresh leaves that are dehydrated and used as a powder or in various forms is gaining popularity as a recent source of very nutritious food.

Objective:

This review attempts to address its nutritional profile, as well as its bioactive chemical ingredients and known food functional activities, as well as its historical usage in food and medicine. To date, several bioactive chemical components from stinging nettle have been identified, including flavonoids, phenolic and amino acids, fatty acids and carotenoids.

Method:

A comprehensive analysis of the literature search was conducted. Several databases have been searched using the common terms Urtica dioica, stinging nettle, phenolic compounds and phytochemicals using Scopus, Science Direct, PubMed-Medline and Google Scholar as search engines.

Conclusion:

The therapeutic potential of Urtica dioica and its disease-preventing strategies are updated in this review article. Also, its classification, chemical composition, nutritive value, and pharmacological activities are enlisted in this review with further future perspectives of Urtica dioica.
Fluorescence Quenching Study of 5-sulphosalicylic Acid Doped
Polyaniline-γ-Fe2O3 Composite for High Energy Material Sensing
(Fe-SPAni)
Authors: Pattathil Shruthy Darley , Ture Satish Ashok , Bertrand Zing Zing , Abbaraju Venkataraman
Published: September 2023

Background:

Polymeric nanocomposites containing metal oxides are of interest to researchers because these materials show hybrid properties that are generated from both components. Due to the control and design of structural properties at the nanoscale scale, they have specialized properties for a range of applications. Researchers have tried to improve the desirable characteristics and thus increase their application by reinforcing them with nanoscale materials to provide them with better properties than conventional micro composites.

Objective:

In our present work we have used 5-sulphosalicylic acid doped polyaniline-γ-Fe2O3 composite (Fe-SPAni) to detect explosives using fluorescence quenching method. Along with ease of synthesis and low cost, Fe-SPAni possesses a variable oxidation state which is important for trace detection of the analytes.

Methods:

We used the fluorophore Fe-SPAni to detect High Energy Materials (HEMs) using the fluorescence quenching approach, which is still difficult to achieve. UV-Vis spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM/EDAX) were used to determine the molecular structure of the Fe-SPAni composite produced by oxidative chemical polymerization; CV studies were performed to investigate the electrochemical properties. HEMs such as dinitrobenzene (DNB), pentaerythritol tetranitrate (PETN), trinitrotoulene (TNT), 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), and hexanitrohexaazaisowurtzitane(CL-20) were used as quenchers.The fluorescence quenching process was determined using the Stern-Volmer graph.

Results:

The Stern-Volmer(S-V) plot and limit of detection (LOD) data showed that PETN had the greatest results for the quenching constant value (Ksv) (Ksv =1.33 x 106 M-1 and 1.4x 10-6M, respectively).

Conclusion:

The research points to Fe-SPAni as a promising contender for sensing explosives.
IoT-based Smart Pill Reminding System
Authors: Nagchandi Akul , Kher Pradyot , Gudipalli Abhishek , Tiwari Amit
Published: September 2023

Background:

The concept of pill reminders has been discussed and developed throughout the decade. It varies from cascaded plastic pill boxes to complicated robust dispensers. This proposed smart pill reminding system based on IoT is being designed by considering ease-to-use and cost-effectiveness.

Method:

A smart pill reminding system is a system that will alert the patient to take their respective pill at the desired time. It will also track the motion of the patient’s hand while taking the pill and will also display the pill count on an LCD Screen. In case a patient forgets/ignores the reminder provided by the system, the system will automatically display the status on the application that will be installed in the relative/caretaker’s phone and through an email on the patient's relative/caretaker’s email address to take subsequent action. The system will monitor the real-time using an RTC module, and as and when the current time matches the medicines time, it will activate its mechanism, and the patient will have a buffer time to take their medicine. In case a patient does take the medicine in the buffer time provided by the system, then one mechanism of the system will be activated. In another case, if a patient does not take the medicine in the stipulated time, further actions will be initiated by the system to benefit the patient.

Results:

It was tested and found that out of ten times, the system worked accurately nine times, with calculated accuracy as high as 90%. Initially, the Blynk application will display “Welcome Patient” and “You will be updated”. Once the RTC matches the scheduled time to take medicine, the buzzer starts buzzing. If the IR sensor detects the movement of the user’s hand, the LCD will update the pill count, and the pill count is reduced by one. The LCD will also display the message “Medicine Taken”. If the IR sensor does not detect the movement of the user’s hand, the LCD will display the same pill count. The LCD will also display the message “Med1 not Taken”. The Blynk will also be updated and will display the same messages. The green LED shows the status of the consumption of the pill. The email will sent to the caretaker in this case.

Conclusion:

In this work, all the problems related to the system are overcome in a systematic manner with the help of IoT and basic electronic applications. Thus, the system will help the user take all the prescribed medicines on time and will also update the user’s caretaker via application and email services. This will largely help the working class as well as the senior citizens. Thus, this proposed system can be commercialised as a handy and cost-effective device.
Penerapan Aplikasi Sistem Administrasi Desa Untuk Mendukung Tata Kelolah Pemerintah Desa Di Desa Mulyoagung Kecamatan Dau
Authors:   Jurusan Statistika Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Iriany Atiek , Ngabu Wigbertus , Solimun Solimun , Efendi Achmad , Ariyanto Danang , Putra Rochmanullah Arditama
Published: September 2023

Desa Mulyoagung adalah sebuah desa di Dataran Tinggi yang terletak di Kecamatan Dau, Kabupaten Malang. Pembangunan desa wisata membutuhkan basis data dan informasi yang harus tersusun secara terstruktur dan sistematis. Salah satu data dan penataan sistem administrasi desa yaitu terkait dengan potensi desa atau pelayanan desa. Melalui analisis situasi, kegiatan pengabdian ini mencoba untuk memetakan potensi desa, terutama dalam pelayanan desa. Pengembangan aplikasi sistem administrasi desa sebagai salah satu alat bantu bagi perangkat desa dalam melayani masyarakat. Penerapan Aplikasi Sistem administrasi desa untuk desa Mulyoagung diharapkan mampu menjadi sarana pelayanan kepada masyarakat secara prima yang dilakukan dengan lebih cepat, tepat, akurat. Pembuatan aplikasi ini menggunakan VBA excel dengan, setiap proses pembuatanan administrasi desa akan dibuatkan berdasarkan database desa yaitu melalui pencarian NIK. Berdasarkan hasil survei yang dilakukan, pemerintah desa sangat puas dengan sistem informasi desa yang telah dibuat. Tentunya, sistem yang dibuat masih perlu penyempurnaan lagi. Dengan adanya inovasi secara terus menerus akan menciptakan sebuah sistem yang semakin baik lagi
PROFIL SENSORI TEH DAUN KARAMUNTING (Melastoma malabathricum L.) DENGAN METODE SENSOMETRIK
Authors: Anandika Lestari Oke , Sri Palupi Nurheni , Setiyono Agus , Kusnandar Feri , Dewi Yuliana Nancy
Published: September 2023

Daun karamunting (Melastoma malabathricum. L) dalam bentuk teh (Tisane) dipreparasi sebagai minuman merupakan salah satu upaya menangani diabetes oleh masyarakat di Kalimantan Barat. Tujuan dari penelitian ini adalah memetakan profil sensori minuman daun karamunting dan atribut sensori yang berpotensi menurunkan tingkat kesukaan dengan metode sensometrik. Teh yang diminati konsumen adalah yang tidak terlalu bitter dan kurang astringency. Metode penyeduhan dapat memberikan persepsi atribut sensori yang berbeda. Profil sensori dan hedonik tisane karamunting (Tikar) dengan berbagai metode penyeduhan dievaluasi menggunakan quantitative descriptive analysis (QDA) dan uji hedonik. Perbedaan metode penyeduhan dengan rasio daun kering:air (7:100 atau 3:100 b/v) digunakan dalam penelitian ini, yaitu seduh panas konvensional (PKV7 dan PKV3), seduh dingin (DKV7), seduh panas dengan drip bag (PDB7), dan seduh panas dengan tea bag (PTB3). Tisane komersial dalam tea bag (PTK3) digunakan sebagai pembanding. Pemetaan profil sensori hasil uji QDA pada berbagai metode penyeduhan dianalisis dengan PCA yang dilanjutkan dengan OPLS-DA dan korelasinya dengan hasil uji hedonik dianalisis dengan OPLS. Hasil dari QDA menunjukkan bahwa Tikar memiliki 14 atribut sensori. Metode sensometrik berhasil memetakan Tikar berdasarkan metode penyeduhan, yaitu PKV7 memiliki aktribut sensori harshness, stew dan astringency, sedangkan metode lainnya (DKV7, PKV7, PKV3, PTB3) greenish color, brightness color, serta fruity, dan PTK3 bitter dan smoky. Tingkat kesukaan tikar dengan metode penyeduhan PKV7 berada diantara metode penyeduhan lainnya dengan PTK3. Hasil penelitian ini menunjukkan bahwa atribut sensori bitter lebih menurunkan tingkat kesukaan dibandingkan astringency. Metode penyeduhan dapat memberikan atribut sensori yang berbeda, sehingga dapat menjadi alternatif sebagai strategi meningkatkan kesukaan.
EVALUATION ON ANTIOXIDANT ACTIVITY AND ACTIVE COMPONENTS OF TRIGONA ITAMA PROPOLIS EXTRACT AND ITS POTENTIAL AS SARS-CoV2 INFECTION INHIBITORS
Authors: Putri Primandasari Elma , Susilo Agus , Umam Al Awwaly Khothibul , Cahyati Miftakhul , Masyithoh Dewi
Published: September 2023

Propolis Trigona itama has a blackish brown color and has a bitter taste. Propolis contains immunomodulator, antibacterial, antifungal and antiviral. Efforts made to determine the potential of propolis require an extraction process. The extraction process aims to obtain propolis ready for consumption. Propolis has thermostable properties with a melting point of 60oC – 65oC, so it does not require high temperatures in the extraction process. The extraction process using MAE requires a faster time because the pressure and temperature can be controlled. This study used a factorial completely randomized design with 2 factors with 9 treatments and 3 replications. The data obtained were analyzed by analysis of variant (ANOVA). If there is a difference, it is continued with the DUNCAN multiple distance test. The results of the extraction using the MAE method of propolis have antioxidant activity using the DPPH method of 1,460µg/ml to 1,413 µg/ml which is expressed in IC50. Trigona itama propolis extract had an average antioxidant value of 0.22 µg/ml to 0.57 µg/ml using the FRAP method.There is a unique component in the GCMS results of Trigona itama propolis extract called bisalcofen.Bisalcofen is an active component which has antioxidant properties. The results of the bisalcofen docking score of -7.6 on the ACE2 protein. Bisalcofen has a stronger potency than umifenovir which can be used as an inhibitor of SARS-CoV2 infection.
Understanding Outsider Art in the context of Digital Humanities
Authors: Roberto John , Davis Brian
Published: September 2023

This chapter introduces the Outsider Art Project. “Outsiders” are highly innovative artists who have been aesthetically and socially marginalized because of their status as psychiatric patients, homeless, recluses, people with disabilities, migrants and ethnic minorities. Because of the need to characterize outsider art on a formal basis, this project is aimed at the automatic discovery of the semantic boundaries of outsider art in the context of digital humanities. From the methodological point of view, the Outsider Art Project is organized around three tasks: collecting a corpus of outsider art, generating a large dataset of digital images about outsider art and building the first ontology of outsider art. Este capítulo presenta el Proyecto de Arte Outsider. Los “outsiders” son artistas muy innovadores que han sido marginados estética y socialmente debido a su condición de pacientes psiquiátricos, personas sin hogar, reclusos, personas con discapacidad, migrantes y minorías étnicas. Debido a la necesidad de caracterizar el arte outsider de manera formal, este proyecto tiene como objetivo el descubrimiento automático de los límites semánticos del arte Outsider en el contexto de las humanidades digitales. Desde el punto de vista metodológico, el Proyecto de Arte Outsider se organiza en torno a tres tareas: recopilar un corpus sobre arte outsider, generar un gran conjunto de datos de imágenes digitales sobre arte outsider y construir la primera ontología del arte outsider.
Desarrollo de un corpus de atlas lingüísticos
Authors: Luna Carolina Julià
Published: September 2023

El objetivo del presente capítulo es la presentación de algunas características y funcionalidades del Corpus de los atlas lingüísticos (CORPAT), una herramienta informática en la que se almacenan datos procedentes de los atlas lingüísticos regionales del español europeo con el fin de conservar el patrimonio lingüístico que contienen; de servir como fuente de divulgación de la variación y la riqueza lingüística; y de complementar los datos procedentes de corpus textuales y obras lexicográficas que permitan ampliar las investigaciones sobre el cambio lingüístico y la historia de la lengua española. The aim of this chapter is to present some characteristics and functionalities of the Corpus of Linguistic Atlases (CORPAT). This computer tool collects data from the different regional linguistic atlases of European Spanish to preserve the linguistic heritage; to serve as a linguistic resource to disseminate knowledge about variation; and to complement the data from textual corpora and dictionaries that allow further research on linguistic change and the Spanish language history.
Methodological bases: the construction of a corpus for the detection of deception and credibility assessment
Authors: Hernández Fuentes Pedro Eduardo
Published: September 2023

Meta-analytic approaches reveal that, to identify lies or evaluate the credibility of a testimony, it is more reliable to perform a discursive or verbal material analysis in contrast to one based on non-verbal behavior. Hence, different research has been developed to make scientific contributions in this regard. These efforts make imperative the need to focus on the construction of a linguistic corpus that enables the study of the subject without ignoring the contributions made from cognitive psychology. Therefore, the methodological proposal for the construction of a corpus on the subject will be developed in this text. This is the result of a transdisciplinary work between linguistics and psychology integrated for a total of 54 cognitive interviews using a double-blind procedure. Los acercamientos metaanalíticos revelan que la información verbal es un indicador confiable para identificar mentiras o evaluar la credibilidad de un testimonio. De aquí que actualmente se han desarrollado diversas investigaciones para realizar aportaciones científicas al respecto. Estos esfuerzos vuelven imperativa la necesidad de enfocarse en la construcción de un corpus lingüístico que posibilite el estudio del tema sin relegar las aportaciones realizadas desde la psicología (cognitiva). Por ello, en este texto, se desarrollará la propuesta metodológica para la construcción de un corpus en el tema. Ésta es el resultado de un trabajo transdisciplinario entre la lingüística y la psicología que consiste en la realización de 54 entrevistas cognitivas con el método de doble ciego.
Recordkeeping Requirements for Private Health Facilities and Services: The statutory perspectives
Authors: Ahmad Abdul Rahman , Chansanam Wirapong , Mansor Ahmad Nazri
Published: September 2023

The study aims to investigate the implications of Malaysian legislation on recordkeeping requirements. These implications are derived from selected provisions where contexts are determined based on records lifecycle components. Using document analysis approach, the Private Healthcare Facilities and Services Act 1998 is a case to examine the contexts and applications of recordkeeping requirements in medical and health services in Malaysia. Results showed that the Act has various recordkeeping implications either explicitly or implicitly indicated. As this area is least explored, more efforts must be made to establish recordkeeping requirements specially derived from statutes to improve records management policy and governance.
Effects of Electronic Records Management Best Practices and Records Professionals in Malaysia
Authors: Micheal Pinky Priscylla , Yunus Mohd Nizam , Abd. Kadir Irwan Kamaruddin
Published: September 2023

Records management operation is vital as it can protect the organization and also helps in achieving its goal. Proper record keeping is critical to ensuring the administration's successful and productive record management. A wide range of records management difficulties and problems in dealing with electronic records, requires a qualified records manager in an organization to implement records management best practices, including how records are kept and maintained. This paper suggests a qualitative study on records managers to find a solution to the problems mentioned. The findings can benefit organizations dealing with electronic records, thus contributing to the body of knowledge.
Inter-Relationship of Cultural Intelligence, Emotional Intelligence, Knowledge Conversion Abilities, and Innovation Work Behavior: A conceptual framework
Authors: Yousaf Furkan , Masrek Mohamad Noorman , Saiful Bahry Farrah Diana
Published: September 2023

Organizations and companies demand their employees' constant innovation, where innovative work behaviour (IWB) is a key element of employee and organization success. As IWB is in the highest demand in the marketplace, research on employees IWB has been continually studied by scholars and researchers. Various models and frameworks are offered to check the effect and relationship of IWB with different variables. The study intended to conceptualize the relationship of three key attributes (emotional intelligence, cultural intelligence, and knowledge conversion ability) that affect IWB. The modal can be helpful for universities, organizations, corporate administration, and government education bodies.
Evaluation of the Clinical Efficacy and Trust in AI-Assisted Embryo Ranking: Survey-Based Prospective Study (Preprint)
Authors: Kim Hyung Min , Kang Hyoeun , Lee Chaeyoon , Park Jong Hyuk , Chung Mi Kyung , Kim Miran , Kim Na Young , Lee Hye Jun
Published: September 2023

BACKGROUND

Current embryo assessment methods for in vitro fertilization depend on subjective morphological assessments. Recently, artificial intelligence (AI) has emerged as a promising tool for embryo assessment; however, its clinical efficacy and trustworthiness remain unproven. Simulation studies may provide additional evidence, provided that they are meticulously designed to mitigate bias and variance.

OBJECTIVE

The primary objective of this study was to evaluate the benefits of an AI model for predicting clinical pregnancy through well-designed simulations. The secondary objective was to identify the characteristics of and potential bias in the subgroups of embryologists with varying degrees of experience.

METHODS

This simulation study involved a questionnaire-based survey conducted on 61 embryologists with varying levels of experience from 12 in vitro fertilization clinics. The survey was conducted via Google Forms (Google Inc) in three phases: (1) phase 1, an initial assessment (December 23, 2022, to January 22, 2023); (2) phase 2, a validation assessment (March 6, 2023, to April 5, 2023); and (3) phase 3 an AI-guided assessment (March 6, 2023, to April 5, 2023). Inter- and intraobserver assessments and the accuracy of embryo selection from 360 day-5 embryos before and after AI guidance were analyzed for all embryologists and subgroups of senior and junior embryologists.

RESULTS

With AI guidance, the interobserver agreement increased from 0.355 to 0.527 and from 0.440 to 0.524 for junior and senior embryologists, respectively, thus reaching similar levels of agreement. In a test of accurate embryo selection with 90 questions, the numbers of correct responses by the embryologists only, embryologists with AI guidance, and AI only were 34 (38%), 45 (50%), and 59 (66%), respectively. Without AI, the average score (accuracy) of the junior group was 33.516 (37%), while that of the senior group was 35.967 (40%), with P<.001 in the t test. With AI guidance, the average score (accuracy) of the junior group increased to 46.581 (52%), reaching a level similar to that of the senior embryologists of 44.833 (50%), with P=.34. Junior embryologists had a higher level of trust in the AI score.

CONCLUSIONS

This study demonstrates the potential benefits of AI in selecting embryos with high chances of pregnancy, particularly for embryologists with 5 years or less of experience, possibly due to their trust in AI. Thus, using AI as an auxiliary tool in clinical practice has the potential to improve embryo assessment and increase the probability of a successful pregnancy.
Enhancing Psychological Counseling with Large Language Model: A Multifaceted Decision-Support System for Non-Professionals (Preprint)
Authors: FU Guanghui , Zhao Qing , Li Jianqiang , Dan Luo , Song Changwei , Wei Zhai , Liu Shuo , Wang Fan , Wang Yan , Cheng Lijuan , Zhang Juan , Yang Bing Xiang
Published: September 2023

BACKGROUND

In the contemporary landscape of social media, a large number of users express negative emotions, including strong suicidal intentions. The situation underscores the critical need for trained psychological counselors to enact effective mental interventions. However, the training of such professionals is often time-consuming, leading to a pressing need for mobilizing non-professionals or volunteers.

OBJECTIVE

This paper aims to introduce a novel model built on the foundation of large language models to fully assist non-professionals in providing psychological interventions in online user discourses.

METHODS

We've developed a specialized counseling support system aimed at enhancing communication between counselors and individuals. Built on a robust Large Language Model (LLM) framework, the system prioritizes user privacy through well-defined policies. It employs meticulously crafted prompts to steer the LLM in assisting counselors with problem analysis and in recommending effective communication strategies. To further safeguard against potential harm, all final feedback undergoes rigorous filtering to eliminate the possibility of generating detrimental comments.

RESULTS

We conducted a comprehensive evaluation involving ten professional psychological counselors with varying levels of expertise. The findings indicate that our system achieves more than 93% expert agreement on its accuracy in analyzing patients' issues. Moreover, it offers satisfactory treatment strategies, as demonstrated by a 78% expert approval rate.

CONCLUSIONS

The research serves as a validation of the application of large language models in the field of psychology. It also lays the groundwork for a new paradigm in community-based mental health support, enabling the meaningful mobilization of non-professional counselors.
Meaningful Social Inclusion and Mental Well-Being Among Autistic Adolescents and Emerging Adults: Protocol for a Community-Based Mixed Methods Study (Preprint)
Authors: McMaughan Darcy Jones , Lewis Casey , McGehee Amy , Noreen Dani , Parker Elliot , Criss Michael M
Published: September 2023

BACKGROUND

In the United States, autistic people face high rates of co-occurring mental illnesses and premature death due to self-harm, which are indicators of threats to mental well-being. Social inclusion may enhance mental well-being and resilience among autistic people. According to Simplican and colleague’s (2015) model of social inclusion for people with intellectual and developmental disabilities, social inclusion is an interaction between community participation and interpersonal relationships. There is limited research on social inclusion that includes the integration of interpersonal relationships and community participation among autistic people or the impact of social inclusion on the well-being of autistic people. Additionally, little evidence exists regarding how autistic people prefer to be included in the community or form interpersonal relationships.

OBJECTIVE

The long-term objective of this project is to improve social inclusion factors to support the mental well-being of autistic people. This protocol describes a community-based, mixed methods pilot study to develop a definition of meaningful social inclusion for autistic people and to understand the relationship between meaningful social inclusion and mental well-being among autistic adolescents and emerging adults.

METHODS

The project uses a community-based, sequential mixed methods design with a formative phase (Phase 1) that informs a survey phase (Phase 2) and concludes with a process evaluation of the community engagement process (Phase 3). During Phase 1, we will recruit 10 community partners (autistic adults and stakeholders) and conduct sharing sessions to cocreate a definition of meaningful social inclusion and a survey of meaningful social inclusion and well-being. During Phase 2, we will recruit 200 participants (100 autistic adolescents and emerging adults and 100 caregivers) to complete the survey. We will examine whether meaningful social inclusion predicts well-being given sociodemographic factors using ordered logistic regression, with well-being categorized as low, medium, and high. During Phase 3, the community partners from Phase 1 will complete a survey on their experiences with the project.

RESULTS

Ethics approval was obtained for this project in March 2023. We have recruited community partners and started the Phase 1 focus groups as of September 2023. Phase 2 and Phase 3 have not yet started. We expect to complete this study by March 2025.

CONCLUSIONS

Using a community-based, mixed methods approach, we intended to develop a definition of meaningful social inclusion for autistic people and understand the role meaningful social inclusion plays in the well-being of autistic people.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/52658
FOSTERING CRITICAL READING AND CRITICAL THINKING SKILLS THROUGH TEACHING PRACTICES IN THE CONTEXT OF ADVANCED (EAP) ENGLISH COURSES
Authors: Spirovska Elena
Published: September 2023

The importance of critical thinking and critical reading skills in higher education and language courses is established and frequently explored, particularly with the shift from traditional to more contemporary teaching methods. The purpose of this study is to elaborate on the implementation of teaching practices with focus on development of critical reading and critical thinking. Both critical reading and critical thinking are considered to be essential parts of the ESP (English for Specific Purposes) and EAP (English for Academic Purposes) syllabi, including English language courses which target the students who are highly proficient in English.  This study attempts to summarize and elaborate on the importance of critical reading and critical thinking skills and to provide further details regarding introducing and teaching these skills through various practices in the context of Advanced English / English for Academic Purposes (EAP)  courses. In addition, the study will focus on students’ perceptions of their critical thinking and critical reading competencies, compared and contrasted with students’ performance and results when introducing activities and tasks which require critical reading and critical thinking. The research methodology is qualitative and includes a 5-point Likert scale survey targeting the student population in EAP courses. Finally, the study will suggest teaching practices and activities which can be used to foster critical reading and critical thinking skills in the context of EAP courses.
USING THE ‘NOTICE-THE-GAP’ PRINCIPLE IN L1 TO L2 LEARNING IN TRANSLATION-ORIENTED FOREIGN LANGUAGE TEACHING
Authors: Emelyanova Yana
Published: September 2023

Nowadays, translation into a foreign language (L2) has become a widespread practice. However, this type of translation is known to be more challenging than translation into the mother tongue (L1). This suggests that translation-oriented foreign language teaching should be geared towards equipping learners with the necessary knowledge, skills and abilities for performing L2 translation. One such aspect is creating a meaningful link between L1 and L2 equivalents and ensuring better retention, recall and retrieval of L2 vocabulary in response to L1 equivalents. The aim of this study was to test whether using L1 to L2 learning in combination with the ‘notice-the-gap’ principle in teaching vocabulary to trainee translators can facilitate the achievement of this result. The participants were thirty 3rd-year full-time translation students enrolled on a 5-year translation training programme at the Linguistics University of Nizhny Novgorod, Russia. The proposed approach was used in teaching vocabulary to an experimental group of students whose results before and after the treatment were compared with those of a control group using statistical tests. The results testify to the effectiveness of the proposed approach. The experimental group demonstrated a significant reduction in the performance time in L2 translation accompanied by improved accuracy of L2 use, i.e., retrieval of appropriate and adequate L2 vocabulary in response to their L1 equivalents. The findings have significant implications for translation-oriented foreign language teaching in terms of highlighting the importance of strengthening the L1 to L2 lexical link. On a practical level, the study provides specific recommendations and a learning procedure for achieving this aim.
A SURVEY OF EMI AT THE TERTIARY LEVEL IN THE ARAB GULF: ACHIEVEMENTS AND CHALLENGES
Authors: Deveci Tanju , Ayish Nader , Midraj Jessica
Published: September 2023

While an abundance of fossil fuels has helped Gulf Arab countries develop rapidly over the past several decades, governments in the region have invested heavily in education, science, and technology relatively recently as a means to diversify their economies in order to ensure their continued growth. In the process, English, as the perceived language of science and technology, has been adopted as the medium of instruction (EMI) in most tertiary institutions. This paper describes how EMI has developed in these countries and the achievements and challenges to date. Recommendations to address these challenges are also given.
TED LECTURES FOR ESP: BEST PRACTICES META-ANALYSIS
Authors: Rudneva Maria
Published: September 2023

The study aims at investigating incorporation of TED talks (TTs) in ESP classes with a specific focus on abundant opportunities TTs provide for teaching intensive and extensive listening. Although the importance of listening comprehension is widely admitted, a few scholars still claim that it remains the most neglected micro-skill of all, a “Cinderella of communication strategies”. This misbalance can be partly put down to lack of graded listening materials of appealing content for lower proficiency students and TTs might serve as a potential remedy for ESP learners. The nature of TTs (with TED standing for Technology, Entertainment and Design) is of great interest for learners due to engaging topics, motivating speakers, easy access and overall user friendliness. Therefore a few SLA instructors have been attempting to utilize TTs in various ways, which include, but are not limited to vocabulary development and retention, listening comprehension, translation skills, speaking assignments varying from guided discussions to oral presentations, reading comprehension skills, writing and summation, EAP, etc. A few integration models have been suggested and evaluated in past literature. The author attempts to draw on those and suggest a detailed account of advances that refer to teaching extensive and intensive listening comprehension.