bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative deficits in depression and in negative mood states as a result of fronto-parietal network dysfunctions
Authors: Brzezicka Aneta
Published: November 2023

Depression is a disorder characterized not only by persistent negative mood, lack of motivation and a „ruminative” style of thinking, but also by specific deficits in cognitive functioning. These deficits are especially pronounced when integration of information is required. Previous research on linear syllogisms points to a clear pattern of cognitive disturbances present in people suffering from depressive disorders, as well as in people with elevated negative mood. Such disturbances are characterized by deficits in the integration of piecemeal information into coherent mental representations. In this review, I present evidence which suggests that the dysfunction of specific brain areas plays a crucial role in creating reasoning and information integration problems among people with depression and with heightened negative mood. As the increasingly prevalent systems neuroscience approach is spreading into the study of mental disorders, it is important to understand how and which brain networks are involved in creating certain symptoms of depression. Two large brain networks are of particular interest when considering depression: the default mode network (DMN) and the fronto-parietal (executive) network (FNP). The DMN network shows abnormally high activity in the depressed population, whereas FNP circuit activity is diminished. Disturbances within the FNP network seem to be strongly associated with cognitive problems in depression, especially those concerning executive functions. The dysfunctions within the fronto-parietal network are most probably connected to ineffective transmission of information between prefrontal and parietal regions, and also to an imbalance between FNP and DMN circuits. Inefficiency of this crucial circuits functioning may be a more general mechanism leading to problems with flexible cognition and executive functions, and could be the cause of more typical symptoms of depression like persistent rumination.
Inhibition of natriuresis in median eminence polydipsia: Effects after intake of diets with different osmolalities and after hypertonic NaCl administration
Authors: Mahia Javier , Bernal Antonio , Puerto Amadeo
Published: November 2023

Lesions in the hypothalamic median eminence (ME) induce polydipsia and polyuria in male rats. A first experiment was designed to examine the effect of salt consumption (standard 0.25 percent Na+ vs. low-salt 0.04 percent Na+ diet) on the fluid-electrolytic balance (plasma sodium, urinary sodium excretion, urine osmolality) and water intake of ME polydipsic animals. In the first 6 h post-surgery, the natriuretic response was higher in ME-lesioned animals than in control groups. At 24 h post-surgery, however, less sodium was excreted by ME rats fed with a standard salt diet (ME/SS), despite showing no decrease in salt intake, and they evidenced an increase in plasma sodium concentration and water intake. Urine osmolality was significantly higher in control animals than in either ME-lesioned group. In experiment 2, hypertonic NaCl administration (2 ml/2M) increased the polydipsic behavior of ME-lesioned but not control rats (day 2). Animals deprived of food/salt showed a significant reduction (on day 2) in the initial (day 1) polydipsia, which increased on day 3 when the animals had access to a standard-salt diet. These results suggest that the reduced natriuretic response and the consequent sodium retention observed in ME animals may exacerbate the hydromineral imbalance of this polydipsic syndrome.
Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of β-amyloid peptide (25–35)
Authors: Ierusalimsky Victor , Kuleshova Elena , Balaban Pavel
Published: November 2023

The expression of matrix metalloproteinase of the first type was studied in frontal sections of the adult rat brain one month after a single intracerebroventricular injection of beta-amyloid peptide (25–35), which is known to be a well-known model of the development of Alzheimer’s disease. Brain sections were stained immunocytochemically to detect MMP-1 expression, and histologically to reveal the state of hippocampal neurons. Administration of beta-amyloid peptide induced a significant degeneration of cells in the dorsal hippocampus. This was demonstrated by a significant decrease in the total number of cells and by the appearance of acidophilic neurons of altered (often triangular) shape. Altered cells were most often found in the hippocampal field CA3, and in a smaller quantity in the CA1 field. MMP-1-like immunoreactivity was found in the same hippocampal areas, the staining being restricted to the cells of altered shape (staining of somata and primary neurites). The data suggest possible involvement of the type 1 metalloproteinase in the development of Alzheimer’s disease.
Impaired fear inhibitory properties of GABA(A) and mu-opioid receptors of the dorsal periaqueductal grey in alcohol-withdrawn rats
Authors: Silva Lais , Nobre Manoel
Published: November 2023

The dorsal periaqueductal grey (DPAG) is a midbrain region that plays a fundamental role on the expression of the anxiety and fear-related responses. Increased fear and anxiety levels are the most frequent symptoms present in the alcohol withdrawal syndrome. This study aims to assess whether GABA and opioid receptors of the DPAG could be implicated in the expression of the conditioned fear state elicited in alcohol withdrawn-rats. For this purpose, we used the fear-potentiated startle (FPS) procedure. Drugs used were the selective GABA(A) agonist muscimol (1 nmol/0.2 microL) and the predominantly mu opiate receptors agonist morphine (10 nmol/0.2 microL). Exposure to aversive cues of the elevated-plus-maze (EPM) was used in order to validate the influence of alcohol withdrawal on emotionality. Data from FPS pointed out to an anxiogenic-like profile of withdrawal, a result sustained by the data collected from the EPM test. Muscimol and morphine showed their well-known anxiolytic-like profile, decreasing the fear-potentiated startle (FPS) amplitude in control subjects. However, the drugs had no effect on the levels of fear evoked in rats pre-treated with and withdrawn from alcohol. It is suggested that this lack of effect was possibly due to the desensitization of the GABA(A) receptors, as well as by the decrease on the responsiveness of the functions of mu-opioid receptors, resulting from chronic administration of ethyl alcohol. These findings shed light on some aspects of the anxiety-like behavior elicited during alcohol withdrawal bringing new information on the influence of GABA and opioid receptors of the DPAG on the expression of unconditioned and conditioned fear responses.
Respiratory activity in the 6-hydroxydopamine model of Parkinson’s disease in the rat
Authors: Budzinska Krystyna , Andrzejewski Kryspin
Published: November 2023

Respiratory disturbances accompany Parkinson’s disease. Weakness of the respiratory muscles or lowering of central respiratory drive might be responsible for respiratory disability. Striatal injection of 6-hydroxydopamine (6-OHDA) simulates motor symptoms of Parkinson’s disease in the rat. Present study investigated whether unilateral infusion of 6-OHDA into the striatum may evoke respiratory disorders and therefore be a model for the study of the respiratory aspects of Parkinson’s disease. Two weeks after the infusion the animals were anesthetized, vagotomized, paralyzed and artificially ventilated. Neural respiratory activity in the vehicle and 6-OHDA treated groups of animals was assessed from the peak amplitude of the phrenic and hypoglossal bursts, frequency of bursts and minute activity during baseline ventilation and acute intermittent hypoxia composed of five 1.5 minute long episodes of 11 percent oxygen introduced every 3 minutes. An impairment of dopaminergic pathways by 6-OHDA evoked separate effects on phrenic and hypoglossal activity. Under baseline conditions the respiratory parameters taken from the integrated phrenic nerve activity unchanged, while the preinspiratory part of the hypoglossal activity (pre-I HG) was reduced both in terms of its onset and amplitude. 6-OHDA did not affect the phrenic response to acute intermittent hypoxia but it increased the hypoglossal response (Fig. 2). Hypoxia activated the pre-I HG in both experimental groups. Although the pre-I HG increased strongly during hypoxic stimulation, the ratio of the pre-inspiratory hypoglossal amplitude to the inspiratory hypoglossal amplitude never achieved similar values as in the sham group. This ratio decreased significantly during secondary decline of the hypoxic respiratory response. A decline of the hypoxic response was more intense in the hypoglossal activity than in the phrenic activity and moved into hypoxic apnoea more frequently in the Parkinson’s disease model. The results indicate a differential modulation of the phrenic and hypoglossal neural output with increased chemical drive when dopaminergic pathways were impaired by 6-OHDA suggesting that such a mechanism may contribute to respiratory insufficiency in Parkinson’s disease. An involvement of a modified mechanism of dopamine efflux and of serotonin and orexin during hypoxia is suggested in the observed changes in the hypoglossal activity in the 6-OHDA model of PD.
Cutaneous afferent regulation of motor function
Authors: Panek Izabela , Bui Tuan , Wright Asher , Brownstone Robert
Published: November 2023

Motor systems must be responsive to the environment in which the organism moves. Accordingly, there are many sensory systems that affect intrinsic motor programs. In this mini review, we will discuss the effects that inputs from cutaneous low-threshold mechanoreceptors have on motor function, focusing on locomotion and hand grasp. A mathematical analysis of grip strength is provided to quantify the regulation of the forces required in maintaining the grip of a moving object. These two behaviours were selected because the neural control of locomotion has been primarily studied for hind-limbs in cats and rodents, whereas hand grasp has been primarily studied in fore-limbs in human and non-human primates. When taken together, insight can be gleaned on the cutaneous regulation of movement as well as the role these afferents may play in mediating functional recovery following injury. We conclude that low-threshold mechanoreceptors are critical for normal motor function and for inducing plasticity in motor microcircuits following injury.
The role of serotonin in the control of locomotor movements and strategies for restoring locomotion after spinal cord injury
Authors: Sławińska Urszula , Miazga Krzysztof , Jordan Larry
Published: November 2023

In this review we will discuss different ways for re-establishing serotonergic activity that can enhance recovery of coordinated plantar stepping after spinal cord injury in adult rats. It is well known that serotoninergic neurons located in the medulla are able to initiate locomotor activity. This effect is exerted by actions on motoneurons and on neurons of the locomotor CPG (Central Pattern Generator). Motoneuron and interneuron excitability is increased, and putative CPG interneurons display oscillatory behaviour in response to serotonin receptor activation. The medullary serotonergic nuclei play multiple roles in the control of locomotion, and they terminate on specific target neurons with different types of serotonergic receptors in the spinal cord. Activation of these serotonergic receptors can restore locomotor movements after spinal cord injury. Specifically, using defined serotonergic agonists the 5-HT2 receptors can be stimulated to control CPG activation as well as motoneuron output, while 5-HT7 receptors to control activity of the locomotor CPG. These results are consistent with the roles for these receptors during locomotion in intact rodents and in rodent brainstem–spinal cord in vitro preparations. The other possibility to encourage the remaining spinal cord circuitry below the total transection to control recovery of plantar hindlimb stepping is restoration of serotonergic innervation by intraspinal grafting of embryonic 5-HT neurons. Our data show that grafting of different populations of 5-HT neurons dissected from embryonic brainstem provides differential control over multiple components of the spinal locomotor circuitry through specific serotonin receptors. Moreover, we demonstrated that the best effect of motor recovery is obtained after grafting of neurons destined to form the B1, B2 and B3 descending 5-HT systems. Using only one of the subpopulations for intraspinal grafting, for example, B3 or the lateral group of 5-HT neurons, induces only partial recovery of plantar stepping with a clear lack of proper interlimb coordination. This confirms the hypothesis that transplantation of 5-HT neurons from specific embryonic sources is necessary to obtain optimal recovery of locomotor hindlimb movement.
Progression of multiple sclerosis is associated with gender differences in glutathione S-transferase P1 detoxification pathway
Authors: Bačić-Baronica Koraljka , Mlinac Kristina , Petlevski Roberta , Ozretić David , Vladić Anton , Kalanj-Bognar Svjetlana , Žuntar Irena
Published: November 2023

The impact of glutathione S-transferases (GSTs) detoxification pathway on complex pathogenesis and heterogeneity of clinical findings in multiple sclerosis (MS), particularly the exact correlation between indicators of clinical severity and different GST genotypes, has not yet been fully elucidated. The aim of the study was to assess the relationship between disability level in multiple sclerosis (estimated by Kurtzke Expanded Disability Status Scale), disease progression (estimated by Multiple Sclerosis Severity Score), the level of brain atrophy and lesion load (determined by MRI) and detoxification status (analyzing glutathione S-transferase P1, GSTP1, genotype profile), in a group of 58 MS patients and 68 age/gendermatched controls. The results present the first evidence on significantly higher frequency of GSTP1 C341T polymorphism (C-T transition) in healthy subjects compared to MS patients, suggesting it may act as a moderating factor in developing MS clinical phenotype. Gender-dependent distribution of the C341T polymorphism was found in both MS patients and controls, with higher frequency of C-T transition in females. In addition, preliminary data showed higher proportion of male MS patients with higher median MSSS scores, as well as lower brain atrophy level and lesion load in MS patients carrying the C341T mutation. Observed gender difference in distribution of the C341T polymorphism in MS patients, as well as in disease progression, suggests that GSTP1 detoxification pathway occurs in a gender-dependent manner and could therefore add to clinical severity in male MS patients.
Neuroprotective effects of histone deacetylase inhibitors in brain ischemia
Authors: Ziemka-Nalecz Malgorzata , Zalewska Teresa
Published: November 2023

Stroke resulting from cerebral ischemia or haemorrhage is a common cause of the death of neuronal cells and neurological dysfunction in humans. Finding therapeutics to improve outcome from brain ischemic injury has proved to be challenging. The efficacy of neuroprotective compounds identified in experimental brain ischemia models thus far have failed to successfully translate in clinical human trials. Recent experimental evidence indicates that inhibition of zinc-dependent histone deacetylases can protect neuronal and oligodendroglial cells from the damaging effects of ischemic insult, chich may contribute to improved functional outcome. In this review we briefly highlight the current data supporting a beneficial role of histone deacetylation in experimental brain ischemia. We also discuss the molecular mechanism of neuroprotection.
Efficacy of GM6001 as an adjuvant to ceftriaxone In a neonatal rat model of Streptococcus pneumoniae meningitis
Authors: Liu Xinjie , Han Qizheng
Published: November 2023

Evidence has demonstrated that matrix metalloproteinases (MMPs) contribute to the pathophysiology of bacterial meningitis; therefore, MMP inhibitors may be a neuroprotective treatment for brain injury caused by meningitis because of their antiinflammatory effects. The objective of this study was to evaluate the effect of the MMP inhibitor GM6001 in a rat model of S. pneumoniae meningitis. For these experiments, 7-day-old Sprague–Dawley rats were randomly divided into an uninfected group, meningitis group, antibiotic group and GM6001+antibiotic group. Uninfected animals were sham infected with sterile saline. Rats in the other three groups were inoculated with S. pneumonia and left untreated, treated with ceftriaxone, or treated with ceftriaxone combined with GM6001. Rats in the meningitis group were severely ill, and MMP-9 was significantly up-regulated. The change in brain water content was consistent with the MMP-9 level. A significant loss of neurons and impaired learning function were observed in the meningitis group. Treatment with the antibiotic and GM6001 significantly down-regulated the level of MMP-9, decreased the brain water content, attenuated neuronal injury and improved learning. Conclusions: GM6001 protected the brain from damage caused by S. pneumoniae, and this effect may occur via downregulating MMP-9 and decreasing brain water content.
Modified phenol chloroform protocol for genomic DNA extraction from keratinous tissue
Authors: Macedo Daralyns Borges , Melo Debora Sayumi Doami , Correa Regianne Maciel dos Santos , Monteiro João Vitor da Costa , De Matos Tauãn dos Santos , Ribeiro Ana Sílvia Sardinha , Moreira Heden Luiz Marques , Moreira Carla Giovane Ávila , Tavares Rafael Aldrighi , Rodrigues Marilia Danyelle Nunes
Published: November 2023

DNA extraction enables the isolation and purification of genetic material by physical-chemical methods. There are specific protocols for different types of samples as animal and plant tissue. However, there are variations and particularities according to the nature of the fabric, such as the high presence of keratin. Thus, the present work aimed to develop and optimize a DNA extraction protocol from feather based on the Phenol-Chloroform method. Feather samples werw collected from 9 birds native to the Amazon region for the genetic material extraction. The DNA was precipitated with isopropanol and washed with 70% ethanol. Subsequently, the pellet was disolved in the TE buffer. The results indicated satisfactory concentrations for post-extraction molecular biology techniques such as PCR. The protocol showed a significant reduction in the incubation time to 1 hour compared to other protocols aimed at feather samples. Addition proteinase K to the lysis solution was the main factor that led to the optimization of the extraction time. The A260/230 and A260/280 absorbance ratios indicated the quality of the extracted DNA being close to what expected. Therefore, the results demonstrate the potential protocol use for molecular biology studies in birds from feather samples. However volume of phenol-chloroform and 70% ethanol can still be adjusted to suit the type sample.
Alta ocorrência da síndrome pós-COVID-19 em dois municípios de médio porte do interior do nordeste do Brasil
Authors: Simião Adriana Rocha , Maia Ana Maria Peixoto Cabral , Lima Ana Loren Girão , Melo Anne Helen Barreto , Teixeira Victorya Leitão Lopes , Borges Juliana Alencar Moreira , De Almeida Paulo César , Alencar Carlos Henrique , Heukelbach Jorg
Published: November 2023

O objetivo foi caracterizar os indivíduos com a síndrome pós-covid-19 em dois municípios de médio porte no estado do Ceará. Realizamos um estudo transversal nos municípios de Sobral e Iguatu, consistindo de aplicação de questionário estruturado sobre sintomas que permaneceram por mais de 12 semanas após covid-19. Um total de 85,0% dos 40 participantes apresentou o desfecho de síndrome pós-covid-19, 92,0% das mulheres e 73,3% dos homens. A faixa etária de 18 a 39 anos teve 84,0% de acometidos e 92,3% possuíam baixa escolaridade. Os sinais e sintomas clínicos mais referidos por 61,8% foram a sensação de fraqueza, cansaço, indisposição ou fadiga, seguido por comprometimento cognitivo com episódios recorrentes de esquecimento, perda de memória ou perda de concentração relatados por 47,1% dos acometidos. A síndrome pós-covid-19 foi caracterizada como muito prevalente entre os participantes do estudo, principalmente na população de adultos jovens, o que pode impactar negativamente na produtividade desta população economicamente ativa.
Adaptações ao teste de hipoclorito em semente de soja
Authors: Madruga Francine Bonemann , Saraiva Carem Rosane Coutinho , Rossetti Cristina , Almeida Andréia da Silva , Tremea Marta Gubert , Madruga Natália Pedra , De Araújo Tassila Aparecida do Nascimento , Da Silva Thiago Antonio
Published: November 2023

Os danos mecânicos na produção de sementes de soja acaba por se tornar um dos principais fatores limitantes no sistema de produção, sem contar o uso do hipoclorito é um produto químico muito nocivo à saúde humana. Diante disso, este trabalho tem como objetivo avaliar a inserção do uso da água em diferentes temperaturas e tempos de embebição nas sementes de soja das cultivares Zeus, Valente, Delta, TMG 7063 IPRO, com a finalidade de substituir o  teste de hipoclorito por um teste mais rápido e sem a utilização do hipoclorito. O teste foi realizado no laboratório de Sementes na Universidade Federal de           Pelotas, na qual foi utilizado 100 sementes, subdivididas em 4 repetições de 25 sementes das cultivares de soja e concentração de hipoclorito de sódio a 1% para a embebição da semente e contado o tempo com auxílio de um cronometro digital (2,4,6,8,10 minutos), diferentes temperaturas de água (20, 30, 40 e 50 °C).Pode observar e concluir que o teste com água quente foi mais efieciente os resultados quando submetidos hipoclorito de sódio a 1%, para ambas as cultivares de soja estudas.
A tributação como forma de auxílio na inclusão social e na garantia dos direitos fundamentais e dignidade da pessoa humana, dentro do mínimo existencial
Authors: Gonçalves Alex Silva , De Araújo Dylvan Castro , Landim Eliveuton Vasques , Santos Elves de Carvalho , Farias Giácomo Tenório , Leal Janaine Marques , Santos Livio Augusto de Carvalho , Morais Manuela Saker , Campelo Filho Mussoline Batista , De Sousa Paulo Phitágoras Rodrigues , Queiroz Vitor Hugo Nunes
Published: November 2023

O presente trabalho tem como objetivo fazer uma análise na conjuntura entre os Direitos Humanos, a Dignidade da pessoa humana, mínimo existencial, na concretização da tributação. Essa correlação existente entre esses direitos, suscitam em diversas conceituações e critérios de análise nos quais determinam as características que fazem parte do nosso ordenamento jurídico. Vale ressaltar, que a tributação como requisito primordial na aplicabilidade das despesas estatais e como premissa para assegurar os direitos fundamentais, possui uma imprescindível importância no ordenamento jurídico e traz um equilíbrio na concretização do constitucionalismo contemporâneo. A correlação existente entre os direitos envolvidos, nos mostra a amplitude na qual estão inseridos os direitos conseguidos no decorrer da história da humanidade.
A práxis pedagógica na formação de professores reflexivos no PIBID/Pedagogia da URCA
Authors: Bezerra Davi Mota , Do Nascimento Maria Luciara Marinho , Da Silva Silene Cerdeira Silvino , Siqueira Luiz Carlos Carvalho
Published: November 2023

A formação inicial docente atua como elemento central de análise do presente trabalho. Buscamos aqui identificar como a práxis pedagógica atua na formação de professores reflexivos no PIBID/Pedagogia da Universidade Regional do Cariri. O trabalho surgiu a partir de discussões encontradas sobre a formação do professor reflexivo e de observações acerca das dissonâncias entre a formação dentro e fora do PIBID, levando em conta o conflito teórico-prático existente nas universidades e na formação inicial dos docentes, conflito este percebido pela falta de práxis pedagógica. Para embasamento teórico do trabalho foram utilizados os autores: Farias (et. al., 2014), Freire (1967, 1987, 2002), Nóvoa (1992), Perrenoud (2002), Tardif (2002), Zeichner (1993), dentre outros. A pesquisa possui natureza básica, de caráter exploratório e de abordagem qualitativa na qual realizou-se entrevistas semiestruturadas com bolsistas e não participantes do PIBID/Pedagogia da URCA, atribuindo observações simples acerca da relação teoria-prática existente no processo formativo dos dois grupos, percebendo como se dá o processo de práxis pedagógica e de formação do profissional reflexivo. Assim, a práxis pedagógica institui-se como prática base na formação do docente reflexivo, percebida como motor central das atividades do PIBID e reconhecida como importante ferramenta no desenvolvimento de profissionais mais bem capacitados para o exercício do magistério, no que diz respeito à construção de uma identidade profissional e de saberes docentes a partir da experiência, processo este que deve ser atribuído desde os primeiros semestres da licenciatura e em toda a carreira docente.
Controle da antracnose em banana ‘Prata Anã’ com óleos essenciais
Authors: Fernandes Martielle Batista , Mizobutsi Edson Hiydu , De Sousa Irisléia Pereira Soares , De Alemida Luciele Barboza , Matos Amanda Dayanne Malta , Moura Marielly Maria de Almeida , De Castro Sabrina Gonçalves Vieira , Santos Michelle de Oliveira , Mizobutsi Gisele Polete
Published: November 2023

Formas alternativas de controle de doenças têm sido buscadas na tentativa de minimizar os efeitos negativos sobre o homem e o meio ambiente. O trabalho teve como objetivo determinar a melhor concentração de óleos essenciais para controlar o desenvolvimento de Colletotrichum musae in vitro e in vivo em banana ‘Prata anã’. No experimento in vitro foram utilizados quatro óleos essenciais das espécies de cravo (Eugenia caryophyllus), árvore do chá (Melaleuca alternifolia), tomilho (Thymus vulgaris) e gengibre (Zingiber officinale), em quatro concentrações: 2, 4, 6 e 8 µL. As variáveis avaliadas foram germinação, crescimento micelial e esporulação. No experimento in vivo foram utilizados nos frutos os quatro óleos testados no experimento in vitro, nas concentrações: 80, 160, 240 e 320 µL. Os frutos foram avaliados quanto à incidência e severidade da antracnose. Dentre os óleos essenciais testados, os óleos de cravo e tomilho foram mais eficientes na inibição do crescimento micelial, germinação e esporulação em todas as concentrações testadas. Os óleos de árvore do chá e gengibre possuem capacidade de suprimir a antracnose em banana ‘Prata anã’.
Plano de parto como estratégia para os direitos e protagonismo das mulheres: uma revisão integrativa de literatura
Authors: Nascimento Felipe Souza , Rodrigues Diego Pereira , Alves Valdecyr Herdy , Ferreira Elisângela da Silva , Da Silva Sílvio Éder Dias , Vieira Bianca Dargam Gomes , Parente Andressa Tavares , De Sousa Ana Zélia Silva Fernandes
Published: November 2023

O estudo teve como objetivo identificar a utilização do plano de parto como estratégia para a garantia dos direitos e protagonismo da mulher. Trata-se de um estudo de revisão integrativa da literatura, com a questão norteadora: Como o plano de parto contribui para a garantia do direito e protagonismo das mulheres no processo do parto e nascimento? Os dados foram coletados em estudos em inglês, espanhol e português entre 2018 e 2022 nas seguintes bases de dados: Bases de dados em Enfermagem; Medical Literature Analysisand Retrievel System Online; Literatura Latino-Americana e do Caribe em Ciências da Saúde; Scopus; Cumulative Index to Nursing and Allied Health Literature e The Scientific Electronic Library Online. Foram identificadas trezes publicações, onde apontaram que o plano ajuda a garantir que suas preferências e desejos, sejam respeitadas como parceiras ativas no processo de nascimento. Por intermédio do plano de parto, as mulheres podem exercer seu direito de serem protagonistas de sua experiência de parto, em vez de se sentirem passivas e submetidas a procedimentos obstétricos. Conclui-se que o plano de parto ajuda a garantir que suas preferências e desejos sejam levados em consideração, e que elas sejam respeitadas como parceiras ativas no processo de nascimento.
Clean City, Green Future: The Path Towards Sustainability Throug Education
Authors: Quispe Ada Patricia Barturén , Farfán Carmen Carreño , Ramos Hilda Angélica Del Carpio , Purihuamán Marilín Sánchez , Scheineder Sebastian Huangal , Guzman Blanca Romero , Hernández Sergio Rafael Del Carpio , Ramos Pedro Antonio Del Carpio , Llanos Segundo Alberto Vásquez
Published: November 2023

Objective: Solid waste management is a topic of growing concern globally due to the environmental, economic and social impacts. In this regard, the objective was to teach the management of household solid waste to a pilot group of families through the application of an environmental educational program, to ensure the sustainability of a clean city with a green future.
Method: Conferences were held with experts in the field, which provided essential information for the formulation of problem, objective, and activity trees. For the application of the program, three key dimensions were considered: knowledge of solid waste and its impact on the environment, the attitude of the population towards the disposal of household solid waste, and citizen awareness regarding the environment. The collection of relevant data was carried out through specific surveys and was validated through the use of the Cronbach's Alpha reliability index. The study sample consisted of 278 participants, with an average of five people per family. The distribution of the surveys was carried out at six randomly selected locations. 
Results: 84 % recognize the importance of education on solid waste management, 92 % show a positive attitude towards waste disposal, and 96 % are committed to sharing knowledge. Furthermore, 88 % value the contribution of recyclers to the recycling chain.
Conclusions: The challenge lies in expanding the pilot program to involve a variety of institutions and businesses, ensuring long-term sustainability and strengthening the role of the municipality in waste recycling and disposal management.
NHỮNG THAY ĐỔI CỦA NGÀNH DỊCH VỤ DU LỊCH TRONG NỀN KINH TẾ SỐ HÓA
Authors: Trương Thị Thu Lành , Lê Thị Bảo Như
Published: November 2023

Trong những thập kỷ vừa qua, sự phát triển của Internet và chuyển đổi sang nền kinh tế kỹ thuật số có tác động sâu sắc, thay đổi nhiều mặt của đời sống xã hội, trong đó có du lịch. Bên cạnh cách thức hoạt động truyền thống, ngành du lịch đã có những bước chuyển mình nhằm bắt kịp xu hướng thời đại, chẳng hạn như sử dụng công nghệ để quảng bá hình ảnh, tìm kiếm khách hàng và cung cấp các dịch vụ tiện ích. Xuất phát từ thực tiễn đã nêu, trong bài báo này, nhóm tác giả sẽ trình bày những thay đổi trong lĩnh vực du lịch trong nền kinh tế số hóa, những khó khăn mà các công ty trong lĩnh vực này đang phải đối mặt và từ đó đề xuất một số kiến nghị giải pháp nhằm nâng cao chất lượng du lịch hiện nay.
GIẢI PHÁP NÂNG CAO CHẤT LƯỢNG DẠY HỌC MÔN BÓNG CHUYỀN HƠI CHO SINH VIÊN TRƯỜNG ĐẠI HỌC VĂN HÓA, THỂ THAO VÀ DU LỊCH THANH HÓA
Authors: Phạm Thị Hồng , Nguyễn Thành Trung
Published: November 2023

Giáo dục thể chất và hoạt động thể dục thể thao trong các trường đại học, cao đẳng là một mặt giáo dục quan trọng nhằm tăng cường sức khỏe và phát triển thể chất cho sinh viên. Bóng chuyền hơi là môn học được bộ môn Giáo dục thể chất xây dựng và giảng dạy nội dung tự chọn trong học phần Giáo dục thể chất của Trường Đại học Văn hóa, Thể thao và Du lịch Thanh Hóa. Đánh giá thực trạng nội dung chương trình giảng dạy, cơ sở vật chất và kết quả học tập môn Bóng chuyền hơi tại Trường Đại học Văn hóa, Thể thao và Du lịch Thanh Hóa là cơ sở để nhóm tác giả lựa chọn những giải pháp tối ưu, nâng cao chất lượng dạy và học môn Bóng chuyền hơi tại Trường.
Tinjauan Perizinan Wisata Air Terjun Tancak Panti (Kajian atas PP RI Nomor 3 Tahun 2008 Tentang Perubahan atas PP Nomor 6 Tahun 2007 Tentang Tata Hutan Dan Penyusunan Rencana Pengelolaan Hutan, Serta Pemanfaatan Hutan)
Authors: Susanti Dinda Rizki , Musfianawati Musfianawati , Hoiru Nail Muhammad , Laily Mufid Firda
Published: November 2023

At the present time, traveling has become secondary requirement for people, to get rid of fatigue after work or just entertain themselves. It takes no less amount of people who like nature tourism and ecotourism. In Jember city, there is one very interesting nature tourism called the Tancak Panti Waterfall which is located in Suci Village. However, the question arises : Can the Tancak Panti Waterfall obtain authorization or licence as nature tourism? Does the Suci Village Government and the local community should be apply for requirements and qualifications to granted the licence? The aim in this article is to determine the method of normative and empirical legal research with the typical characteristics of the methods of researching Law. The result of the first discussion is that the Tancak Panti Waterfall Tourism Destination has the right to obtain licence as nature tourism in accordance with Article 33 Number (1) of Government Regulation Number 3 of 2008 on amendments to Government Regulation Number 6 of 2007 concerning Forest Management and Preparation of Forest Management Plans, As well as Forest Utilization which states that the Tancak Waterfall can obtain licence for nature tourism. The result of the second discussion is that the Suci Village Administration and the local community have the right to apply for licence in accordance with Article 67 Paragraph (2) of Government Regulation Number 3 of 2008 regarding amendments to Government Regulation Number 6 of  2007 concerning Forest Management and Preparation of Forest Management Plans, as well as Forest Utilization.
Perlindungan Hukum Terhadap Data Pribadi bagi Nasabah Pinjaman Online
Authors: Duwi Rindiantika Wafia , Laily Mufid Firda , Winiari Wahyuningtyas Yuli
Published: November 2023

Online lending or peer to peer landing as a form of financial technology is the result of technological advances that offer many loans with easier and more flexible terms and conditions when compared to conventional financial institutions such as banks. But it turns out that behind this convenience, of course there are consequences and risks that will be received by borrowers if they violate their obligations. In the last few years to date, the OJK, which is part of the Investigation Alert Task Force, still finds and blocks illegal online loan services, because they cause many problems for their users, several cases have ended with borrowers ending their lives because they cannot be strong enough to be billed by debt collectors. Apart from that, the problem with online loans after billing with terror is the transfer of contacts. Blender can read all cellphone transactions and photos. So that the protection of personal data is still low. Indonesia does not yet have a personal data protection law, so that business actors go around with online loan users.
Acompañamiento directo para la mejora de la práctica docente en la unidad educativa Albertina Rivas Medina
Authors: Posligua-Burgos Karen Julissa , García-Espinoza Margot Mercedes , Castro-Bermúdez Idelisa Esther
Published: November 2023

El acompañamiento directivo para la mejora de la práctica docente es importante en el ámbito educativo porque permite que se logren mejoras para poder implementar en la praxis y en este sentido la institución educativa pueda alcanzar nuevas habilidades cumpliendo con lo que indica el Ministerio de Educación del Ecuador en los estándares educativos. El objetivo de la investigación fue elaborar una propuesta de intervención para el proceso de acompañamiento directivo que fortalezca la práctica pedagógica de los docentes en la Unidad Educativa Albertina Rivas Medina. El estudio se realizó bajo un enfoque mixto, se aplicaron los métodos teóricos, empíricos y estadístico. El estudio se realizó en la Unidad Educativa Albertina Rivas Medina en el nivel de Bachillerato, se aplicó una encuesta de base estructurada a los docentes y una entrevista a los directivos de la institución. Los resultados detectan que los docentes necesitan incrementar sus conocimientos en el dominio de estrategias didácticas y metodológicas para que tengan buenas prácticas de aula, esto evidenciado en las evaluaciones aplicadas en donde los resultados indican que no cumplen con los estándares educativos del Ecuador. Se concluye que el acompañamiento directivo para la mejora de la práctica docente es importante para detectar las problemáticas en el proceso inherentes a la institución educativa proponiendo mejoras en ellos alcanzando altos puntajes en las evaluaciones que realizan los asesores pedagógicos.
COMO A SINDROME BURNOUT PODE AFETAR MULHERES DOCENTES
Authors: Anaquiri Ezineide Rodrigues , Dantas Sebartiã Romulo de Oliveira , Martins Gizelly de Carvalho
Published: November 2023

O estudo sobre a Síndrome de Burnout em mulheres docentes é de total relevância na seara da psicologia, pois tal transtorno aparece como uma reação a tensão emocional crônica gerada a partir do contato direto e excessivo com outras pessoas, sendo que cuidar ou dar atenção a outros exige grandes responsabilidade, principalmente no âmbito educacional. Objetivo: A pesquisa tem como objetivo geral, desenvolver um estudo sobre o que ocasiona a Síndrome de Burnout nas mulheres docentes.  Métodos: O presente trabalho é um estudo é sistemático e de revisão integrativa, o qual elege como campo de pesquisa a área de saúde mental. Discussão: No decorrer da pesquisa ocorreu uma coleta de dados e análise bibliográfica em estudos pertinentes ao tema, pois entende-se que o Burnout em mulheres é consequência de um processo crônico de estresse, sendo válido ressaltar, que na tal transtorno está relacionado fatores importantes em relação a vida profissional. Conclusões: Portanto, nos últimos dez anos as mulheres docentes tem sido diagnosticadas com mais frequência com a Síndrome de Burnout, sendo que muitos estudos estão mostrando que o cotidiano exigente dessa profissional é o que desencadeia tal transtorno.
IMPACTOS DA DEPRESSÃO PÓS-PARTO NO CRESCIMENTO E DESENVOLVIMENTO DA CRIANÇA
Authors: Nunes Jemima de Sousa , Alves Igor Felix Guimarães , Lopes Graciana de Sousa
Published: November 2023

Objetivo: Analisar os impactos da depressão pós-parto no crescimento e desenvolvimento da criança e o papel da família como apoio social a puérpera. Materiais e Métodos: Revisão bibliográfica do tipo integrativa mediante as bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino- Americana em Ciências da Saúde (LILACS), Biblioteca Virtual em Saúde (BVS)e Google Acadêmico, com o cruzamento dos descritores “Depressão Pós-Parto”, “Fatores de Risco”, “Sentimento de Abandono” e “Desenvolvimento Cognitivo”. Resultados: Segundo com os materiais selecionados para o estudo constataram-se desordens no crescimento e desenvolvimento infantil e psiquiátricos, falta de amamentação, comprometimento no desenvolvimento comportamental e de QI de crianças em diversos domínios, nascimento prematuro, baixa natalidade-peso e restrição de crescimento intrauterino. Conclusão: A prevenção da DPP é a melhor maneira de impedir tais consequências, é relevante elaboração das políticas públicas, dos pesquisadores e dos profissionais de saúde.
Real Structures and Divine Action Externalism: A Solution to Benacerraf's Problem
Authors: Schultz Walter J.
Published: November 2023

Paul Benacerraf claimed in 1973 that realist accounts of truth which are applicable to propositions of both mathematics and science inevitably conflict with accounts of how propositions are known. This article presents a solution to the problem based on two assumptions: (1) that the God of the Bible is absolutely self-sufficient; and (2) that God is creating, providentially guiding, and redeeming according to his plans for his purposes in Christ. A coherent synthesis of what these assumptions entail itself entails that “abstract” and physical structures are real and that propositional knowledge of them is a matter of one’s cognitive faculties functioning properly due to God’s acting.
Virtue and Artificial Intelligence
Authors: Schuurman Derek C.
Published: November 2023

Two questions concerning artificial intelligence (AI) and virtue are explored. The first question is whether AI is capable of virtue, and the second question explores if AI can assist humans in the acquisition of virtue. It is argued that AI cannot be a moral agent and therefore cannot genuinely be virtuous. However, AI can perform behaviors that are in accordance with virtuous behavior. The notion of "virtue-by-proxy" is introduced in which virtuous programmers can strive to design AI programs that are trained to mimic certain virtues or behave in accordance with virtue. Next, it is argued that since AI systems can nudge humans toward repeated practices and habits, they will inevitably shape and form users. Thus, AI systems might be designed to assist humans with virtue formation; likewise, they could be misdirected to encourage certain vices. Finally, the concept of virtue in the Christian tradition is contrasted with secular notions of virtue and is used to inform limits on the role of AI in virtue formation.
THE PRIORITY OF RATIONAL PROOF IN ISLAM: THE VIEW OF FAKHR AL-DĪN AL-RĀZĪ
Authors:   Institute of Islamic Understanding Malaysia (IKIM), Malaysia, Mohd Shahran Mohd Farid
Published: November 2023

This article analyses the instrumental and foundational roles of rational proof in Islam, as reflected in Islamic theology and with special focus on the thought of a renowned Muslim theologian of later Ashʿarite school, Fakhr al-Dīn al-Rāzī (1149–1209). The priority of rational proof, the way he had articulated it, lies in its two important roles in regard to revelation: being the basis for the justification of revelation (aṣl al-naql) as well as being an important criterion in verifying the certainty of revelation. While the first becomes clear via the role of reason in proving the existence of God which forms the basis of one’s belief in the Qurʾān, the Divine Speech of God, the second becomes evident in the importance of the ten rational criteria in determining the truth of a revealed text. The article contends that the aforementioned priority as expounded by al-Rāzī is still relevant and any attempt at relearning it shall render one’s contemporary approach to revelation more comprehensive and systematic.
ISLAMIC FEMINISM FULLY EXPOSED: AMINA WADUD AND MARGOT BADRAN VIS-À-VIS ʿALLAMA YŪSUF AL-QARAḌĀWĪ AND JAMĀL BADAWĪ ON WOMEN’S ISSUES
Authors:   International Islamic University Malaysia, Malaysia, Kausar Zeenath
Published: November 2023

Discourses on Islamic feminism are traced back to the 1980s but within three decades, it has spread globally and attracted many Muslim scholars from all over the world. However, since its inception, Islamic feminism has remained controversial, due to its term, agenda and stance on several issues on women, which are never accepted by several eminent Islamic scholars of contemporary times. This article discusses the views of Islamic feminists—the renowned scholar Amina Wadud, and the strong advocate, Margot Badran — and contemporary Islamic scholars—ʿAllama Yūsuf al-Qaraḍāwī and Jamāl Badawī. Both the Islamic feminists and Islamic scholars are shown to ‘share’ their views on certain issues, somehow ‘bear’ each other on some others with some difference, yet ‘tear’ the views of each other on certain others due to diametrical differences. This raised a few questions on Islamic feminism which fully expose that the term ‘Islamic feminism’ has less of Islam but more of feminism and that it is not created to present the Islamic stand on women’s issues, but rather to promote feminism globally.
Wound healing and antiulcer activities of Solenostemma oleifolium (Nectoux) Bullock & E.A.Bruce ex Maire essential oil in rats
Authors: Benmaarouf Daouia K. , China Bernard , Aliboudhar Hamza , Boulahlib Soumiya , Zenia Safia , Bensedira Hanane , Bouzid Kheira , Slimani Assia , Ben-Mahdi Meriem H.
Published: November 2023

Context: Solenostemma oleifolium is a Saharan plant part of the traditional pharmacopoeia to treat wound and gastric problems. This work supports the presence of active compounds in the essential oil of S. oleifolium, facilitating the healing process. Aims: To evaluate the wound healing and antiulcer effects of the essential oil of S. oleifolium (EOSO). Methods: EOSO was prepared and analyzed by gas chromatography and mass spectrometry (GC-MS). The toxicity of the product was evaluated by an acute toxicity test and a skin toxicity test. A 1% EOSO cream was prepared and used. The percentage of wound contraction was monitored in an excision model in rats. A histopathological study was conducted on the damaged tissue throughout the experiment. For the ulcer study, two assays were performed in rats: the aspirin-induced gastric ulcer and the pyloric ligation-induced gastric ulcer assays. In the aspirin test, the ulcer index and the percentage of ulcer protection were calculated. Results: The major compounds of the EOSO were linalool (57.1%), terpineol (12.95%), and trans-geraniol (12.66%). EOSO was not considered toxic. In the excision rat model, from day 2 to day 10, the wound contraction was significantly higher (p<0.05) for the EOSO-treated wound than for the non-treated wound. In the aspirin-induced ulcer test, the ulcer index was significantly reduced in the EOSO-treated rats compared to the control rats (p<0.05). Conclusions: The present study demonstrated the wound healing and antiulcer properties of the essential oil of S. oleifolium.
Efecto antitumoral del extracto etanólico de Prunella vulgaris L. en linfoma murino in vivo
Authors: Almaguer Georgina , Molina María E. , Alanis Ernesto , Becerril Marco A. , Camacho Abelardo , Díaz Alberto , Montejano José R.
Published: November 2023

Context: Prunella vulgaris L. is a plant used by various cultures around the world due to its antitumor effect, among others. In vitro investigations have described various mechanisms of cytotoxic action but, it is necessary to further extend the observations of in vivo models, whit the possibility of analyzing the effect on tumor grown, time of life, as well as toxicity, which that will allow to promote the possible use of P. vulgaris in cancer in a safe and effective way. Aims: To evaluate the antitumor effect of P. vulgaris L. on L5178Y lymphoma in BALB/c mice as well as its acute toxicity in CD1 mice. Methods: For the tests, the crude ethanolic extract of P. vulgaris was used. Acute oral toxicity was studied in female CD1 mice. The antitumor effect was observed with the L5178Y ascitic tumor model, the effect on tumor growth and survival of the groups with vehicle, vincristine and with the extract were compared. Results: In the toxicity test, no mouse died at the doses used. In relation to the antitumor effect, it was observed that tumor growth was lower both in the positive control and in the different doses used of the P. vulgaris extract compared to the vehicle, while the estimate of survival was similar in the vehicle and in the groups with the extract. Conclusions: In this work, the ethanolic extract of P. vulgaris did not show toxicity and inhibited tumor growth, without improving survival.