bluuebunny/crossref_metadata_2025 huggingface dataset:
The Antibacterial Activities of Lavandula angustifolia L., Mentha piperita L., and Ribes nigrum L. against Oral Bacteria, and Their Antioxidant Activities
Authors: Okmen Gulten , Mammadhkanli Mahabbat , Arslan Kutbettin
Published: September 2022

There is an expanding interest in medicinal and aromatic plants as a natural alternative to synthetic drugs, especially to antimicrobial agents due to the growing problem of antibiotic resistance. In recent years, a lot of reports have been published on the antimicrobial activity of the plant extracts. This study was used Lavandula angustifolia L., Mentha piperita L., and Ribes nigrum L. as plant materials. This study aims to test the plant extracts against oral bacteria. Its purpose is to produce directly comparable, quantitative, antimicrobial data, and in addition to containing very little information of the different extracts against oral pathogens. Disc diffusion method was studied for antimicrobial activity tests. Also, minimum inhibitory concentration (MIC) values were determined in this study. Additionally, the extracts were tested against stable 2,2-diphenyl-1-picryl-hydrazyl-hydrate• (DPPH•) free radicals for non-enzymatic antioxidant activity. This study was used Trolox (6-hydroxy-2,5,7,8-tetra-methyl chroman-2-carboxylic acid) as standard. The extracts showed different inhibition zones against bacteria. The methanol extract of Lavandula showed the highest inhibition zone against the oral pathogen MBKK5. The positive control was penicillin (10 μg). The lowest MIC value was taken at 6500 μg /ml concentration of the plant extracts. The highest DPPH• radical scavenging activity was found in Ribes nigrum extract as 36%. As a result, plant extracts have antibacterial and antioxidant potential.
Relationship between Unemployment Rate and Economic Growth in Nepal: An Econometric Estimation
Authors: Thapa Rabin , Dhakal Shiva Chandra , Gurung Bikash
Published: September 2022

Economic growth and employment are taken as the two major objectives of macroeconomic policy schema in both the developing as well as developed countries. This study aims to determine the relationship between the unemployment rate and GDP growth rate of Nepal using the time-series data from 1991-2020. Difference version approach, dynamic version approach and Granger causality test were used to study the relationship between the macroeconomic variables. The difference version and dynamic version approach showed non-significant results for the regression of unemployment rate on economic growth rate which implies that the unemployment rate is not significantly affected by the economic growth rate of Nepal. The Okun’s coefficient in the difference version was -0.057 and in the dynamic version approach it was -0.058. Thus, the Okun’s law doesn’t seem to hold in case of Nepal’s economy. The Granger causality test also revealed that the change in the unemployment rate is not a predictive variable of the GDP growth rate and vice versa. The non-significant relationship between the macroeconomic variables might thus be affected by other factors. Thus, it can be suggested to the government and policymakers to recuperate the ways of solving the unemployment by formulating economic policies that are more directed towards structural and labor market transformation. Tax reduction policy, increase in government spending, skill enhancement programs and youth employment subsidy can also be suggested.
Analysis of the Spatial Perception of Antalya Vocational and Technical Anatolian High School as a Historical Building
Authors: Kolak Hatice , Aşıkkutlu Hüseyin Samet , Kaya Latif Gürkan
Published: September 2022

This study aimed to analyze the spatial perception of educational buildings with historical significance by users. In this context, Antalya Vocational and Technical Anatolian High School, which is a historical building, was discussed as a material. A questionnaire was applied to individuals who graduated from this high school to examine how the facade design and garden layout were perceived in the spatial evaluation of the high school discussed in the study. Three different facade designs (modern, traditional, and mixed) based on the building complex were prepared using the AutoCAD, 3D Max, and Photoshop CS3 programs to be used in the questionnaire form consisting of open-ended and closed-ended questions. The frequency analysis was performed using the SPSS program to evaluate the data obtained after the questionnaire. According to the obtained results, it was determined that the middle age group was highly interested in the traditional and mixed facade design. It was observed that the participants further preferred the modern facade design as their level of education increased. It was observed that the participants preferred the mixed facade design more as their income level increased. Furthermore, it was determined that the mixed facade design was generally preferred more by the participants. In conclusion, the quality of historical buildings from the past should be updated with a modern perspective. Thus, positive effects will be achieved for the continuity of the building and its compliance with the environment. It is foreseen to provide positive effects both in terms of functionality and in the field of visual admiration and comfort by evaluating the changing needs of society over time and environmental factors together. On the other hand, while positive elements ensure the continuity of buildings and building complexes, it will also be possible to contribute to their becoming an urban image.
Sirolimus treatment of a PTEN hamartoma tumor syndrome presenting with melena
Authors: Şahin Gülseren Evirgen , Hoşnut Ferda Özbay , Yeşil Şule , Lafcı Naz Güleray , Gül Aylin Ege , Şahin Gürses
Published: September 2022

Background. PTEN hamartoma tumor syndrome (PHTS) is an umbrella term including Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and PTEN-related Proteus-like syndrome. One of the disorders in PHTS spectrum, CS is characterized by macrocephaly, mucocutaneous findings, gastrointestinal system (GIS) polyposis and an increased lifetime risk of GIS, breast, thyroid and other cancers.
Case. In this study, we report an adolescent patient presenting with recurrent life-threatening upper GIS bleeding as a result of hamartomatous polyposis. Genetic studies revealed a known pathogenic nonsense mutation confirming the initial diagnosis of CS.
Conclusions. Additionally, we describe our therapeutic intervention to improve the patient`s clinical symptoms with sirolimus, which its use is infrequently addressed in the literature for pediatric age group harboring PTEN mutations.
The role of self-discontentment and impulsivity for youth smoking behavior, nicotine dependence and future smoking intention in a clinical sample of Turkish adolescents
Authors: Uygun Sabide Duygu , Arı Demet Aygün , Ünlü Hande Konşuk , Çetinkaya Semra
Published: September 2022

Background. Smoking is one of the most important public health problems among young people. Potential risk factors that may cause vulnerability to smoke in youth should be well known and investigated. The aim of the present study was to evaluate the associations of current smoking behavior and future smoking intention with high-risk personality traits for substance abuse in a clinical sample of Turkish adolescents, and also evaluate nicotine dependence and smoking characteristics with the personality traits in a subsample of regular smokers.
Methods. A cross-sectional study was adopted in which 196 participants took part (aged 14-18 years with a mean of 16.7 years). The assessment consisted of a sociodemographic questionnaire that also questions current smoking behavior and future smoking intention; and additionally, two self-administered instruments including the Substance Use Risk Profile Scale (SURPS) for all participants, and Fagerström Test for Nicotine Dependence (FTND) for only regular smokers.
Results. Regular smokers scored higher than never smokers on the lack of self-contentment subscale of SURPS (F(2)=3.30, p=.039). Future smoking intention was found to be associated with nicotine dependence (F(3)=6.67, p=.001). Regular smokers with high levels of nicotine dependence had higher levels of impulsivity and smoked more cigarettes per day than those with low levels of nicotine dependence (t=2.489, p=.017; and t=3.530, p=.001, respectively). The structural equation models (SEM) were created based on these results and the personality theory for substance abuse. The SEM results showed that the first evidence that lack of selfcontentment positively influences regularly smoking behavior and impulsivity positively influences future smoking intention through nicotine dependence.
Conclusions. Lack of self-contentment and impulsivity may mediate the transition from current smoking behavior to future tobacco use disorders in Turkish adolescents. The assessment and intervention of selfdiscontentment and impulsivity can be beneficial in reducing the current smoking behavior in Turkish adolescents.
Claudia Peña Claros: una lenta poética en un mundo veloz
Authors: Velásquez Guzmán Mónica
Published: September 2022

En este trabajo, se analiza la construcción de una poética de la lentitud, en el libro de cuentos Los árboles de Claudia Peña, tomando en cuenta tres rasgos: la descripción, el detalle y el goce verbal a partir del ritmo. A contrapelo de un mundo afligido por la velocidad, esta escritura ralentiza el tiempo para priorizar el proceso de cada acción en vez de su sitio en la secuencia narrativa y la dificultad de los personajes para elaborar lo que les sucede antes que sus relaciones concretas o sus perfiles acabados. Se iniciacon una descripción de los recursos, para llegar a una posición autoral de resistencia y de apuesta por el lenguaje de lo viviente en su multiplicidad.
Claudia Peña Claros: a slow poetic in a fast world
AbstractThis work analyzes the construction of a poetics of slowness in the book of stories Los árboles of Claudia Peña taking into account three features: description, detail and verbal enjoyment from the rhythm. Against the grain of a world afflicted by speed, this writing slows down the time to prioritize the process of each action instead of its place in the narrative sequence and the difficulty of the characters to elaborate what happens to them before their concrete relationships or their finished profiles. It begins with a description of resources, to reach an authorial position of resistance and commitment to the language of the living in its multiplicity.
Recibido: 24 de mayo de 2022Dictaminado: 30 de mayo 2022Aceptado: 6 de junio 2022
Perbandingan Perubahan Luas Luka dan Angiogenesis pada Luka Bakar Derajat IIB Tikus Sprague Dawley yang Diberikan Advanced Platelet-rich Fibrin dan Advanced Platelet-rich Fibrin Plus
Authors: Stella Ellia , Wahyuningsih Komang Ardi
Published: September 2022

Platelet-rich fibrin (PRF) has a lot of benefits in the process of healing. The new generation of PRF, namely advanced PRF plus (A-PRF+), has a different fibrin structure and more growth factors compared to Advanced PRF (A-PRF), the generation before A-PRF+. Objectives:To compared the effects of A-PRF and A-PRF+ on the IIB degree burn. Methods: This experimental study used 20 male Sprague Dawley rats. All rats were given IIB degree burn and divided into four groups. Group 1 was treated with saline, Group 2 was treated with silver sulfadiazine 1%, Group 3 was treated with A-PRF, and Group 4 was treated with A-PRF+. Wound size reduction will be calculated every two days and measured with ImageJ and the wound would be made into a histological slide on day 14 to calculate angiogenesis. Results: Changes in the wound surface area for the group that was given A-PRF dan A-PRF+ are 2,333cm and 4,827cm. The wound surface area’s data were analyzed using Kruskal-Wallis and the results are statistically not significant (p>0,05). The number of angiogenesis for the group that was give A-PRF and A-PRF+ as followed are 5,88 and 4,867. The angiogenesis data were analyzed using one-way ANOVA and the results are statistically not significant (p>0,05). Conclusion: There is no difference between the effect of A-PRF and A-PRF+ towards changes in wound surface area and angiogenesis in IIB degrees burn wounds.Keywords:  A-PRF, A-PRF+, burn wound, angiogenesis, wound surface area
Coronavirus Disease 2019 in Chronic Kidney Disease: A Case Report
Authors: Jalmas Dela Hangri , Fauzar Fauzar , Kurniati Roza , Viotra Deka , Harun Harnavi , Yoga Vesri , Kam Alexander
Published: September 2022

The COVID-19 pandemic has caused substantial morbidity and mortality worldwide. Older patients, male gender and those with preexisting comorbidities such as chronic kidney disease are reported to be more likely infected with SARS CoV-2 and are at higher risk of severe illness or death. It has been reported a 24 years old male was admitted to the hospital with shortness of breath, coughing, fever and paleness. The history of contact with confirmed COVID-19 cases was unclear. The patient works as a security officer. A history of hypertension is present. Laboratory results showed hemoglobin 7 g/dl, ureum 261 mg/dl, and creatinine 22,9 mg/dl. On the second day of admission, the patient experience increased shortness of breath, decreased consciousness and epistaxis. From the result of the nasopharyngeal swab, the patient tested positive for COVID-19 and was given Oseltamivir 75mg. The patient is prepared for hemodialysis, which was performed in the isolation room. After hemodialysis, the patient's condition improved with decreased shortness of breath and increased of consciousness. The patient comes out from the isolation room and discharges home in good condition. Antiviral therapy in CKD patients with Covid-19 infection requires dose adjustment. Immediate hemodialysis is required in patients with CKD and coexisting COVID-19 infection to improve the patient's condition. Prompt management for patients with CKD and COVID-19 will reduce the risk of mortality.Keywords:  COVID-19, chronic kidney disease, hemodialysis
Efek Suplementasi Selenium terhadap Marker Darah Pasca Cedera Kontusio
Authors: Daba Mariel , Goenawan Hanna , Tarawan Vita Murniati , Rosdianto Aziis Mardanarian , Lesmana Ronny
Published: September 2022

Selenium is a trace element that has antioxidant properties and is a component of selenoproteins. In certain circumstances, such as injury, selenium supplementation is required to regulate the inflammatory response. Contusion injury increases the inflammatory response to a muscle or tissue that begins with vasodilation, increases blood flow, increases vascular permeability, and leads to edema formation at the site of injury. Objectives: To determine the effect of selenium supplementation on changes in blood markers in rats treated with contusion injury. Methods: Experimental design, using experimental male rats (Rattus norwegius), eight weeks old, weighing 200-220 grams, divided into three groups, namely: The Control group, the contusion group, the contusion + Selenium group. Selenium supplementation was given orally on days 1-3 after injury at a dose of 0.0153 mg into 2% PGA. Examination of markers such as White Blood cells (WBC), lymphocytes, monocytes, and neutrophils was carried out on day three after treatment. Results: This study found that the administration of post-muscular selenium supplementation based on examination of blood markers such as WBC, Lymphocytes, Monocytes was higher in the contusion group and lower in the selenium group. Neutrophils were higher in the contusion and selenium groups. This was not significantly different from the control group. The result of blood marker examination tended to change, but it was not statistically significant. Conclusion: Selenium supplementation in post-contusive injury mice did not provide significant changes in blood markers such as WBC, lymphocytes, monocytes, and neutrophils.Keywords:  antioxidant, blood marker, contusion, selenium
Gambaran Drug Related Problems (DRPs) Terapi Farmakologi Pasien ISPA Pediatrik di Rumah Sakit PKU Muhammadiyah Gamping Yogyakarta
Authors: Husna Nadia , Padmasari Siwi
Published: September 2022

Acute Respiratory Infection has become the major cause of death in children in developing countries. There were about 11.9 million episodes of severe acute lower respiratory infection that resulted in hospital admission in young children worldwide. The method of drug administered was the common Drug-Related Problems found in young children. Objectives: To evaluated Drug-Related Problems of Acute Respiratory Infection drug therapy in pediatric patients. Methods: Ninety-four pediatric patients were included in this study. Drug therapy data were obtained from medical records from January 2018 until July 2019, as this study was using a retrospective method. Drug-Related Problems of drug therapy were analyzed based on the Cipolle classification system. Results: Prevalence of female and male patients are in the same number (50%) with the highest prevalence on 2-11 years (72.34%) in young children. The number of Drug-Related Problems was found about 61.49% from 148 numbers of used drugs with improper drug selection as the major Drug Related Problems (51,65%)  followed by drugs without indication and underdose by 23.08% and 15.38%, respectively.Keywords:  acute respiratory infection, hospital, pediatrics, pharmacologic therapy
Nicolau’s syndrome following intramuscular administration of Diclofenac sodium
Authors: Dhurve Vaishali Atram , Surjushe Amar Uttamrao , Saraswat Anand Virendra , Mundada Neha Baheti
Published: September 2022

Nicolau’s syndrome, also known as embolia cutis medicamentosa or livedo-like dermatitis, is an uncommon rare cutaneous adverse reaction occurring at the site of intramuscular, intra-articular, or rarely subcutaneous injection of particular drugs, leading to necrosis of skin and underlying tissues. We, hereby, report two fatal cases of this syndrome after taking intramuscular injection of diclofenac sodium.
The effectiveness of bilastine and fexofenadine updosing in the management of chronic spontaneous urticaria
Authors: Shah Bela , Choudhary Ankita , Mistry Deval , Jangid Neha , Shah Shikha , Kamat Shruti , Deshmukh Gaurav Anil , Dhoot Dhiraj , Barkate Hanmant
Published: September 2022

Objectives:

In patients not responding to standard dosages of second-generation antihistamines (SGAHs), updosing up to 4-fold is recommended. Even though SGAHs are safe, the concerns regarding their safety after updosing still remain and the studies directly comparing the updosing of different SGAHs are lacking thus making the choice of drug difficult.

Material and Methods:

Eighty patients with chronic spontaneous urticaria (CSU) were randomized to receive either bilastine or fexofenadine (40 in each group). Patients were started on conventional dose of either drug (bilastine 20 mg or fexofenadine 180 mg) for the first 2 weeks. Those patients who remained symptomatic after 2 weeks (UAS ≥ 7) were given double dose of bilastine (20 mg BD) or fexofenadine (180 mg BD), respectively, for another 2 weeks. Control of urticaria was assessed by evaluating UAS score. Patients’ quality of life was assessed by CU-Q2oL questionnaire. Safety was evaluated by analyzing the adverse events (AEs) reported by the patients.

Results:

Seventy-four patients completed the study. Forty-one patients (bilastine – 23 and fexofenadine – 18) achieved adequate control of urticaria (UAS ≤ 6) at week 2. Out of 33 patients who were given high dose of bilastine or fexofenadine, 17 patients (bilastine – 9 and fexofenadine – 8) achieved adequate control of urticaria at week 4. Bilastine was associated with significant improvement in quality of life of patients compared to fexofenadine (32.38 ± 5.83 vs. 38.71 ± 5.92.; P < 0.005). Thirteen patients (six in bilastine group and seven in fexofenadine group) reported one or more AEs with sedation being the most common side effect.

Conclusion:

Updosing of bilastine provided relief from urticaria symptoms, improved quality of life in the majority of the patients without compromising somnolence or safety. Bilastine was associated with improved quality of life and less sedation compared to fexofenadine.
Juvenile angiolipoma in the subtemporal region, zygomatic, and pterygomaxillary fossa treated by microwave ablation – A case study and literature review
Authors: Ramírez Adrián Santana , Gutiérrez Sergio Valente Esparza , Rodríguez Pedro Avila , Ortiz Omar Alejandro Santana , Heredia Jesús Nicolás Serrano
Published: September 2022

Background:

Angiolipomas are benign mesenchymal tumors that infrequently affect the head-and-neck region and can appear with infiltrating and non-infiltrating forms. Surgical excision is the treatment of choice; however, there are other alternatives to manage this condition whose consideration is quite useful to evaluate per each particular case.

Case Description:

An 11-year-old girl was diagnosed with non-infiltrating angiolipoma in the subtemporal region, the zygomatic, and pterygomaxillary fossa; she had a history of having undergone surgery on two previous occasions with a failed resection attempt due to the high vascularization of the injury and significant transoperative bleeding. The condition was managed with minimally invasive techniques through microwave ablation, requiring two sessions, achieving very satisfactory results both esthetically and in the final size of the lesion.

Conclusion:

The microwave ablation technique may turn out to be a very useful tool for the management of lesions with high vascularization such as angiolipoma. This technique offers a new possibility for initial management, both independent of and complementary to other management techniques for other lesions at the base of the skull and/or facial massif regions.
Spinal cord infarction after coil embolization of a basilar tip aneurysm: A case report and literature review
Authors: Imura Jun , Fujita Atsushi , Umeda Subaru , Fujimoto Yosuke , Kohta Masaaki , Sasayama Takashi
Published: September 2022

Background:

Spinal cord infarction is a rare but serious complication of neurointervention that has been rarely documented. An association between spinal cord infarction and the placement of large bore catheters in the vertebral artery (VA) has been mentioned, but the precise etiology remains unclear.

Case Description:

A 72-year-old female presented with the right hemiparesis and left thermal hypoalgesia directly after endovascular coil embolization for an unruptured basilar tip aneurysm. Magnetic resonance imaging demonstrated right-sided upper cervical (C2-3) spinal cord infarction. Conventional bilateral vertebral angiograms revealed no opacification of the anterior spinal arteries. Cone-beam computed tomography showed a watershed area of radiculomedullary arteries that was correlated with the extent of the ischemic lesion. Thus, the spinal cord ischemia may have had multifactorial causes combined with reduced perfusion pressure to the spinal cord, which was caused by the placement of the guiding catheter in the VA and intensive hypotension during general anesthesia.

Conclusion:

Spinal cord infarction should be recognized as a serious complication of endovascular treatment involving posterior circulation.
Mobile Wound Management System Application: A Three-year Retrospective Study of its Effect on Quality of Coding Pressure Injury at Three Acute Care Hospitals
Authors: Estocado Nancy , Dickson Lattrice
Published: September 2022

Introduction. The consistency of coding the reported severity of pressure injuries (PIs) present on arrival and hospital-acquired PIs remains unknown. Objective. The authors conducted a 3-year retrospective review of hospitalized patients from 200-, 400-, and 700-bed acute care facilities before (preimplementation, year 1) and after (postimplementation, years 2 and 3) introduction of the mobile wound management system application (WMS app). Materials and Methods. On October 1, 2018, the WMS app and an accompanying educational initiative were rolled out to hospital staff at all 3 facilities. Results. The number of PIs determined to be present on arrival was significantly different between years 1 and 2 at both the 200-bed facility (P =.0221) and the 400-bed facility (P =.0138) and between years 2 and 3 at the 400-bed facility (P <.0001). There was a significant difference in the number of stage 3 and stage 4 PIs among all PIs reported between preimplementation and postimplementation (P =.0456), between years 1 and 3 (P =.0068), and between years 2 and 3 (P =.0382) at the 200-bed facility, as well as between preimplementation and postimplementation (P =.0072), between years 1 and 2 (P =.0284), and between years 1 and 3 (P =.0076) at the 400-bed facility. At the 400-bed facility, there was a significant difference in the number of hospital-acquired conditions (HACs) among all reported PIs between years 1 and 2 (P =.0427) and between years 2 and 3 (P =.00009). At the 700-bed facility, there was a significant difference in the number of HACs among all reported PIs between preimplementation and postimplementation (P =.00004), between years 1 and 2 (P =.0013), and between years 1 and 3 (P =.0038). Conclusions. This study shows that the WMS app was successfully implemented, and its use enhanced overall wound care.
Innovative Treatment Utilizing an Autologous Blood Clot for Diabetic Foot Ulcers
Authors: Williams Marie , Davidson David , Wahab Naz , Hawkins Jessie , Wachuku Chinenye , Snyder Robert
Published: September 2022

Introduction. Diabetic foot ulcer is a complex wound that requires considerable effort to restart a stalled healing process. In this study, a TABCT product was used in a point-of-care setting to treat DFUs by reconstructing the ECM and adjusting intricate phenotypes and mechanisms of mediators to progress towards complete healing. The mechanism of action consists of reconstruction of the ECM, which protects the wound area from further destruction while it incorporates into the ulcer to promote granulation over exposed vital structures (ie, tendons, bone, and neurovascular structures). Objective. The authors evaluated the efficacy of the TABCT product in the management of DFUs. Materials and Methods. Study participants were wound care patients in hospitals and clinics across the United States and Israel as part of a registry study (ClinicalTrials.gov: NCT04699305). Twenty-nine patients age 18 years or older with chronic DFUs were included. A blood clot was created using the patient’s own peripheral blood in a point-of-care setting. An 18-mL blood sample was drawn from the patient and incorporated with calcium gluconate and kaolin to form a clot. Efficacy and superiority levels in PAR at week 4 and week 12 over the SOC treatment were established using the Agresti-Coull confidence interval. Results. Treatment of DFUs using the TABCT product resulted in 22 patients (75.86%) achieving 50% PAR at week 4 and showed superiority when compared with SOC data in previously published studies. Complete closure was achieved in 28 wounds (95%) at week 12. Conclusion. In the current study, TABCT exhibited superiority over SOC treatment and provided granulation over vital structures with a reduction in overall wound size in a timely manner via incorporation and stimulation of the body’s own healing capabilities.
HUBUNGAN ANTARA TINGKAT PENGETAHUAN DAN SIKAP PERAWAT TERHADAP PELAKSANAAN PROGRAM INDONESIA SEHAT DENGAN PENDEKATAN KELUARGA DI PUSKESMAS KOTA PONTIANAK
Authors: Prianti Lola , Maulana Muhammad Ali , Fahdi Faisal Kholid
Published: September 2022

PIS PK is the main health development program that is carried out within the working area of the puskesmas. The level of knowledge and attitudes possessed by nurses may influence the implementation of PIS PK program. Objective:To analyze the relationship between the level of knowledge and attitudes of nurses towards the implementation of PIS PK program on public health center in Pontianak city. Method:Quantitative research with a cross sectional research design. The instrument used is a question related to the level of knowledge, attitudes and implementation of PIS PK. The sample was taken using a stratified random sampling technique and the number of research respondents was 48 people. Result : Statistics results with the chi square test obtained p value 0.131 which is greater than 0.05 (0.131> 0.05) for the relationship between knowledge and implementation of PIS PK. Statistics results for the relationship between nurses' attitudes with the implementation of PIS PK chi square test obtained p value 0,000 which the value is less than 0.05 (0,000> 0.05). Conclusion : There is no significant relationship between the level of knowledge and the implementation of PIS PK in the Pontianak city health center. However, there is a significant relationship between the level of knowledge and the implementation of PIS PK in the Pontianak city health center Keyword : Attitude Nurses, Knowledge Level, Pis Pk
Electronic Effects of Aminoindenyl ligands Coordinated to Manganese: Structures and Properties of a Mn(0) Metalloradical and Bimetallic Mn(-I)/Mn(I) Adduct
Authors: Tresp David , Neugebauer Hagen , Grimme Stefan , Hansen Andreas , Prokopchuk Demyan
Published: September 2022

Amine-functionalized indenyl ligands were reacted with Mn(I) precursors to form the piano-stool complexes Mn(CO)3(IndR) (R= Pyrrolidinyl, piperazinyl) which exhibit two cathodic redox waves via cyclic voltammetry. Electrochemical, spectroscopic, and structural comparisons of these complexes with the undecorated indenyl species reveal that the pyrrolidine-substituted tricarbonylmanganese complex MnIndPyrr is the most electron rich due to favorable π donor effects from the amine into the ring system. These results are also strongly supported by DFT computations. Chemical reduction of MnIndPyrr in the presence of the cation encapsulating cryptand 2,2,2-Crypt resulted in the formation of the rare monometallic Mn(0) metalloradical, [K(2,2,2-Crypt)][MnIndPyrr] which was characterized by single crystal X-ray diffraction, EPR spectroscopy, IR spectroscopy, and DFT calculations. Attempts to isolate a doubly reduced Mn(-I) adduct in the presence of 18-crown-6 resulted in indenide loss to generate a mixed-valence Mn(-I)/Mn(I) adduct where the two metal centers bind to a single indenyl moiety. The pyrrolidine-substituted indenide anion can be independently prepared in high yields by the facile direct re-duction of the protonated indene in the presence of 2,2,2-Crypt. The order of addition and the identity of the encapsulating agent are critical to the observed reaction outcomes, highlighting their decisive role under reducing conditions.
Twitter como herramienta de comunicación institucional: la Casa Real Británica y la Casa Real Española en el contexto postpandémico
Authors: Pulido-Polo Marta , Jiménez-Marín Gloria , Pérez Curiel Concha , Vázquez-González José
Published: September 2022

La Casa Real es, probablemente, la más alta institución del Estado como sistema monárquico. En este sentido cabe cuestionarse cómo estos organismos han gestionado la comunicación, con sus públicos de interés, durante una situación de crisis como ha sido el periodo temporal de pandemia y postpandemia, donde el Foro Económico Mundial establece que es una época de reinicio donde es necesario un gran reinicio social y económico. El objetivo principal de este trabajo es conocer el comportamiento institucional de las casas reales británica y española a través de sus respectivas cuentas de Twitter para determinar convergencias, sinergias y estilos comunicativos en el entorno digital. Todo ello buscando las claves de la gestión estratégica de las relaciones de ambas instituciones con su ciudadanía. Se estableció un diseño metodológico cuantitativo, sustentado en el análisis de contenido (coeficiente alfa de Kripendorff = 0,852) sobre un corpus de 2211 mensajes emitidos durante 2021 por las cuentas oficiales de Twitter @RoyalFamily (1025 tuits) y @CasaReal (1186 tuits). Los resultados muestran una diferencia significativa en los contenidos emitidos, la regularidad de la frecuencia de los tuits por hora de emisión y las tasas de interacción, viralización y engagement de cada una de las cuentas analizadas. Estos resultados evidencian que Twitter es una poderosa herramienta de comunicación capaz de buscar el interés mutuo que sugieren los postulados relacionistas en periodos de transición.
El periodismo como protagonista esencial en la trama de la serie The Crown
Authors: San José-De la Rosa Cristina , Gil-Torres Alicia , Miguel-Borrás Mercedes
Published: September 2022

Los medios de comunicación desarrollan un papel clave en el guion de la exitosa serie de Netflix The Crown (Peter Morgan, 2016-2020), puesto que en sus 40 episodios aparecen multitud de acciones relacionadas con la información. El periodismo resulta esencial en la agenda diaria de la familia real y de los políticos y se convierte en protagonista indiscutible para unir la trama, incluso con algunos capítulos en los que ocupa más de la mitad del tiempo. Para cuantificar la presencia del periodismo en las cuatro temporadas, esta investigación utiliza un método estructuralista inspirado en el libro Morfología del cuento (1928), del ruso Vladimir Propp, que extrajo 31 funciones o acciones irreductibles tras analizar cien cuentos tradicionales. Este trabajo se sostiene en la plantilla de elaboración propia Morfología del periodista en el cine, con 70 funciones en tres esferas: con alto, medio y bajo impacto del periodismo. Entre las conclusiones destaca la presencia constante de periodismo desde los primeros minutos de cada episodio hasta el final, con lo que titulares, flashes, emisiones en radio o imágenes en televisión marcan el ritmo del hilo narrativo en cada capítulo y se convierten en el enlace entre familia real y políticos y la sociedad. Se observa además la supremacía del trabajo de los periódicos sobre la radio y la televisión y también se detecta el predominio de temas sensacionalistas vinculados a la vida personal de los miembros de la realeza y de los temas políticos trascendentales para el país. Esta investigación se convierte así en un testimonio nuevo de la fructífera unión entre periodismo y cine. Es además otro documento de la historia del periodismo británico y su decidida vinculación con la Corona y la vida política de Inglaterra durante varias décadas de la segunda mitad del siglo XX.
Medical chatbot using AI and NLP
Authors: Vinita Kumari Pal , Sonali Singh , Anshita Sinha , Mohammad Sohail Shekh
Published: September 2022

The use of chatbots has grown rapidly across industries, including marketing, assistive systems, education, healthcare, cultural heritage, and entertainment. This paper discusses the incentives for using chatbots and explains how useful chatbots are in various contexts. As intelligent software and hardware, also known as intelligent agents, are developed and analyzed, Artificial Intelligence (AI) is becoming more and more integrated into daily lives. From manual labor to complex procedures, intelligent agents are capable of performing a wide range of tasks. One of the simplest and most common forms of intelligent human-computer interaction is the chatbot, which is a classic example of an artificial intelligence Human-Computer Interaction (HCI) system. A chatbot is described as "a computer program designed to simulate interaction with human users, particularly over the Internet." In addition to chatbots, it also called smart bots, interactive agents, digital assistants, and intelligent conversational objects. In the midst of the COVID-19 pandemic, going to the doctor is no longer an indulgence. A chatbot is a Natural Language Processing (NLP) based chatbot to help with basic medical questions. Only the best knowledge of a chatbot can be used to answer medical questions.
Secure software development: industrial practice - a review
Authors: Henry O. Nwaete
Published: September 2022

The current state of application assets with respect to their development, functionality, scalability, user friendliness, and compatibility with legacy systems has witnessed an unprecedented degree of positive improvements. This induced increase in productivity and value has been a product of the technological innovations within and around the software development landscape. Owing to specific software development practices including software reusability, Object Oriented Programming (OOP), encapsulation, and portability, all sectors of the economy have come to embrace software products that have helped to drive business transactions. Nonetheless, the proliferation of software which has driven up the velocity, veracity and volume of data associated with transactions has become a goldmine for grabs. Hackers and adversaries alike have thus capitalized on this development to exploit the potential threats and vulnerabilities associated with software products. Insecure software is global issue, and one that impacts individuals, organizations and governments. Data loss is both a security and privacy issue, with compliance, regulatory and legal concerns, and bad actors are relentless in their efforts to steal, deface, alter/manipulate, destroy, and compromise software systems. Organizations should therefore embrace secure code principles, threat modeling, and institute a Secure Software Development Lifecycle (SSDLC) practice that will aid the embedment of security into the development phase, to contain the risks, threats, and vulnerabilities that are inherent in software development. This paper demonstrates an effort to provide and arm organizations with the necessary tools, processes, and mechanisms that can be leveraged to combat cyber-threats and enforce Information Assurance (IA) within and around enterprise application assets. Beginning with an overview of the contemporary software development practices witnessed in diverse organizations, including financial, energy, aviation, commerce, nuclear, defense, and several other Critical Infrastructure (CI) organizations, the tenets of a composite, structured and robust. SSDLC has been presented to promote a defense-in-depth security for enterprise organizations.
Chemical and microbial changes of stingray fish (Trygon sephen) during soaking
in salt solution before smoking process
Authors: Suprapto H. , Kumalaningsih S. , Wignyanto W. , Santoso I. , Sucipto S.
Published: September 2022

The salting process at a fisherman's level is still traditional and does not yet have a
standard for salt concentration and soaking time, thus affecting the freshness and quality
of fish for further processing. For this reason, it is necessary to conduct research that can
maintain the quality of fish before the smoking process to ensure results can be
recommended for fellow fishermen. This research aimed to find the best quality of lowsalted stingray fish (Trygon sephen) treated with different salt solution concentrations and
soaking time durations before the smoking process. This study used three levels of salt
solution concentration (10%, 20%, and 30% w/v, respectively) as the first factor and
soaking time duration (1 hr, 2 hrs, and 3 hrs) as the second factor. Chemical and microbial
analyses of samples were performed during treatment to investigate their quality. The
results showed that stingray fish soaked in 10% salt solution for 1 hr was the best
treatment. In this treatment, the pH, total plate count (TPC), total volatile base nitrogen
(TVB-N), and trimethylamine nitrogen (TMA-N) values were 6.92, 4.98×105 CFU/g, 6.12
mg N/100 g, and 5.56 mg N/100 g, respectively. Meanwhile, protein loss in this treatment
was 2.66. In conclusion, treatment with 10% salt solution for 1 hr could be used in
stingray fish considering that this treatment resulted in good quality with the lowest
protein loss. Furthermore, this treatment is used as a reference for the smoking process
because the concentration of the salt solution is low and the soaking time duration is short.
Desde la periferia española: obra inicial de las arquitectas canarias Magüi González y Maribel Correa
Authors: Delgado Baudet David
Published: September 2022

Dentro del territorio español, la condición periférica de Canarias supone un agravante para la visibilización del trabajo de sus arquitectas. El presente artículo efectúa un análisis con perspectiva de género del contexto profesional de las arquitectas canarias en los años posteriores al régimen franquista.  La lejanía y carácter insular del territorio trajo consigo singularidades que afectaron al proceso formativo de sus profesionales, motivó cambios derivados de la constitución de las autonomías y llevó al colegio profesional de las islas a impulsar ciertas iniciativas para la promoción de la disciplina. Entre ellas destacan la publicación de la revista Basa (1982-2008) y el Premio Manuel Oraá de Arquitectura, que supusieron una ventana de oportunidades para la proyección de las arquitectas isleñas. Los comienzos profesionales de Magüi González y Maribel Correa, egresadas durante la Transición, sirven para evaluar su mirada en la concepción del proyecto arquitectónico y efectuar un análisis metacrítico sobre la recepción de alguna de sus obras dentro del discurso de las narrativas dominantes del momento.
MARÍA NOVAS - Arquitectura y género. Una introducción posible
Authors: Amoroso Serafina
Published: September 2022

María NovasArquitectura y género. Una introducción posibleSanta Cruz de Tenerife: Melusina, 2021. 192 pp. Tapa blanda. Idioma: español. 16,90 €ISBN 978-84-18403-37-8
Isolation of viable monkeypox virus from anal and urethral swabs, Italy, May to July 2022
Authors: Moschese Davide , Pozza Giacomo , Mileto Davide , Giacomelli Andrea , Cutrera Miriam , Cossu Maria Vittoria , Matone Maddalena , Beltrami Martina , Salari Federica , Antinori Spinello , Lombardi Alessandra , Rizzardini Giuliano
Published: September 2022

Anal and urethral samples from confirmed cases of monkeypox were screened for monkeypox virus (MPXV) by real-time PCR. Isolation of the virus was subsequently attempted in cell culture. Actively-replicating virus was demonstrated in 13 of 18 and 11 of 15 PCR-positive anal and urethral swabs, respectively, collected within 7 days from symptoms onset. Two asymptomatic secondary cases had detectable MPXV genetic material in urethral secretion and for one, MPXV was successfully isolated, supporting a potential MPXV sexual transmission hypothesis.
Expositio super elementationem theologicam Procli. Sach- und Quellenregister
Authors: von Moosburg Berthold
Published: September 2022

Der Registerband erschließt den Inhalt der acht Bände der kritischen Edition von Bertholds Prokloskommentar (insgesamt über 2000 Druckseiten) in dreifacher Hinsicht. Er bietet erstens ein alphabetisches Sachregister mit 580 Einträgen, das auf einer vom Verfasser selbst hergestellten Tabula contentorum basiert. Es folgt zweitens ein Register aller durch die Herausgeber genau nachgewiesenen Quellen, der aus 9300 Einträgen besteht, welche der Verfasser 300 Werken von 80 verschiedenen Autoren entnahm. Das Register wird durch ein Namen- und ein Literaturverzeichnis abgeschlossen. Dieser Band eröffnet den Zugang zu den wichtigsten Themen der mittelalterlichen platonischen Überlieferung, so wie Berthold sie verstand; darüber hinaus gibt die erstaunliche Breite der von Berthold aus erster Hand zitierten Quellen eine einmalige Einsicht in die reale Bibliothek eines deutschen Gelehrten aus dem Spätmittelalter.
Analisis Intensitas Konsumsi Energi (IKE) pada Institut Teknologi Dirgantara Adisutjipto (ITDA) Yogyakarta
Authors: Purnami Ndaru Atmi , Arianti Refni , Setiawan Paulus
Published: September 2022

One of the main sectors that uses the largest electrical energy in a country is the commercial sector. One of the parts of this sector is education. This sector has a sub-sector. It is called a building. Electrical energy conservation efforts are needed to streamline electrical energy consumption by looking at energy-saving opportunities. This research was conducted at Halim Building and Wiweko Building in Institut Teknologi Dirgantara Adisutjipto (ITDA), Yogyakarta. The research was conducted by taking energy audit data regarding the level of electrical energy consumption as seen from the Energy Consumption Intensity (IKE) parameter. The research method began with the data collection. Furthermore, the data were processed using Ms. Excel, SPSS, and Matlab. Statistics analysis with ANOVA was carried out to conclude what parameters affected IKE. The results showed that the IKE value of the Halim Building was 30,48 kWh/m2/year and the IKE value of the Wiweko Building was 24,16 Wh/m2/year. The IKE value was still significant in the efficient category following   ESDM & JICA Electric Power Development Co. LTD standards.
Spontaneus pneumomediastinum and subcutaneus emphysema in nonventilated COVID-19 patient
Authors: Moczulska Beata , Żechowicz Maciej , Gromadziński Leszek , Nowek Paulina
Published: September 2022

Introduction

The most common complications of COVID-19 infection are: pneumonia, acute respiratory distress syndrome, pulmonary fibrosis, pulmonary embolism, pneumothorax and pneumomediastinum.

Aim

We would like to highlight the rarity of pneumomediastinum and subcutaneous emphysema in nonventilated COVID-19 patient.

Case study

A 50-year-old man was addmitted to the COVID-19 Department with SARS-CoV-2 pneumonia. The patient wasn’t vaccinated against COVID- 19. Upon admission the general condition was quite good with mild dyspnea.

Results and discussion

Upon admission a CT scan was performed in which there were bilateral infiltrates consistent with COVID-19 infection, covering approximately 50% of the lungs. On the 5th day of hospitalization the general condition deteriorated and a drop in saturation was observed. A follow-up CT scan revealed progression of lung inflammatory changes that spanned approximately 60%–70% of lung parenchyma; there was pneumomediastinum and subcutaneous emphysema in the neck, left subclavian, and axillary area. High flow nasal oxygen therapy (60 L/min) was administered. On the 13th day the general condition of the patient further deteriorated and blood saturation continued to drop which prompted the decision to escalate treatment. Initially, noninvasive ventilation was used, however, shortly after the patient was intubated. Immediately after intubation the patient went into cardiac arrest that ultimately led to his death.

Conclusions

The development of spontaneus pneumomediastinum in the patient can be mainly attributed to the intense cough and rapidly developing acute respiratory distress syndrome in the course of SARS-CoV-2 infection despite aggressive treatment with steroids, tolicizumab, and antibiotics for staphylococcal pneumonia.
Educación escolar para el desarrollo social y económico en Guinea Ecuatorial
Authors: Nguema-Nkié Ciriaco
Published: September 2022

La educación ayuda al hombre al acercamiento de su cultura, a la comprensión de sí mismo, es decir, de lo que es; ser consciente de lo que tiene y de lo que puede; le hace capaz de poder comprender, dominar y transformar su entorno sociocultural para vivir mejor, por lo que una educación escolar adecuada a las necesidades sociales de un país, puede contribuir al desarrollo social y económico del mismo. El objetivo de esta investigación fue un estudio sobre la adaptación de la educación escolar en Guinea Ecuatorial, contribuir a la formulación de una nueva realidad educativa, adaptada a las necesidades económicas y sociales, que favorezca el desarrollo social y económico del país, relacionar la escuela con la cultura local y con el entorno social de los ecuatoguineanos. Metodológicamente, el estudio estuvo enmarcado bajo un enfoque cualitativo, no experimental, descriptivo; se usó la entrevista como método de recolección de información, apoyado en un diseño documental. Entre los resultados más relevantes se obtuvo como reclamo general, la necesidad urgente de la introducción de los valores y elementos socioculturales ecuatoguineanos en la educación escolar. Y como conclusión más significativa, se puede afirmar que no hay desarrollo social ni económico si la educación escolar no se adapta a la realidad sociocultural de las personas, si no le ofrece las herramientas adecuadas para poder hacer frente a los distintos desafíos de su entorno vital.