bluuebunny/crossref_metadata_2025 huggingface dataset:
Sociodemographic evaluation of patients with rheumatoid arthritis in the state of roraima, extreme north of Brazil: A descriptive study
Authors: Garcia Chumpitaz Narottam Sócrates , Castro e SIlva Janderson de , Cunha Almeida Heuller Pablo , Ponte Prado Aguiar Thays Karolyne , Ramos Bendaham Lucas Cael  Azevedo , Prado Aguiar Aline Candido , Oestreicher Guilherme Ferreira , da Silva Bruno Leitão , de Souza Iara Leão Luna , Santos da Silva Rodrigo dos , Cruz Carbonell Roberto Carlos
Published: March 2023

Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory disease. Consequently, the need for observational research, which aims at a quantitative/descriptive approach based on documentary and field research with the intention of analyzing the prevalence and incidence of rheumatoid arthritis in Brazil, especially in the state of Roraima, which are scarce. The aim of this study is to analyze the prevalence and incidence of rheumatoid arthritis in the state, as well as other epidemiological aspects such as the profile of patients. That said, 150 participants were obtained, of which women represented 92,0%. The most patients were between 50-59 (34.7%) and 60-69 (29.3%) years old, and also most declared themselves to be brown (82,0%). It was demonstrated that 65.3% of the patients were not born in the state, and 79.3% live in the urban area. In addition, the declared mean education level was complete high school (38%), and 63.3% of patients as well are unemployed. As for family income, 45.4% is between 1 and 3 minimum wages. Evidently, it is possible to relate advanced age, low income and lack of higher education with the prevalence of RA, as factors such as lack of knowledge reduce the haste with which the patient seeks health services, and low income also makes it impossible to pay for health privately, which offers faster services. Therefore, resident rheumatologists and civil servants in the city state claim that the number of patients with RA can reach up to twice the number of respondents, so the need for multicenter studies with large samples of patients over the years is evident.
Consolidation of Cu- and Ti-based metal powders using layer-by-layer, spot pulsed electric current sintering
Authors: IA Elkin , VA Volkov , KS Stolbov , DA Kolodkin , AA Chulkina , AN Beltyukov
Published: March 2023

In this paper, we propose a technique for additive manufacturing of bulk materials from electrically conductive powders, based on the method of point wise electro pulse sintering. This method consists of layer-by-layer consolidation of powders, each layer being formed as a result of successive sintering of small portions of powder compressed between the electrode and the substrate, or between the electrode and the previously sintered layer. Using the proposed method, bulk samples were obtained from powders having the different chemical composition (Cu, Ti, mechanically alloyed tin bronze), and particles of various shapes (dendritic, dumbbell, stone-shaped). Using X-ray diffraction, electron microscopy, and micro hardness measurements, the structural phase states, and porosity of the obtained bulk consolidated materials were studied. Sintering of powders using this method is greatly influenced by the heat release along the boundaries of the particles, which in turn depends on the electrical resistivity of the material. The porosity of the sintered samples mainly depends on the type of powder used and decreases with the decreasing size of the powder particles. Keywords: additive manufacturing, electro pulse sintering, metal powders, porous structure
Clinical-pathological characteristics and management of fusocellular tumors. Our experience
Authors: Rosa Abate Camila , Gian K Urey , Florencia Costa M , Daniela Maltagliatti , Veronica Sanchotena , Laura Santoro , Diego Flaks , Claudia Arias
Published: March 2023

Introduction: Fucocellular tumors encompass a spectrum of very rare entities. Prognostic factors for the risk of relapse and overall survival such as tumor size, surgical margin, histological strain, and stromal growth are described. Materials and methods: Observational, analytical and cross-sectional study, which studied patients with a diagnosis of fusocellular tumor, treated in the Breast Pathology Service of the Marie Curie Municipal Oncology Hospital (HOMC) of Buenos Aires during the period 2003 to 2022. Quantitative variables were used and analyzed with measures of central tendency. For the comparison of these variables, the Chi 2/Fisher exact test was used. Results: A total of 58 patients with diagnosis of spindle-cell lesions were recruited, including Filode tumors, sarcomas, hamartomas, adenomyoepithelioma, aggressive fibromatosis, gigantocellular granuloma, fusocellular lesion. Conclusion: It was observed that early age (<40 years) is not a risk factor for relapse, with an increase in this index in patients with tumor size > 5 cm. The percentage of relapses was not modified when conservative surgeries vs mastectomies were compared.
Toxicity of cadmium salts on indicators of embryogenesis of rats
Authors: Kolosova I. I. , Shatorna V. F.
Published: March 2023

Cadmium is a toxic heavy metal which is considered a dangerous environmental pollutant and has a detrimental effect on the organs of the reproductive system, the period of implantation and the development of embryos. The experiment presented in this article established the effect of cadmium salts (chloride and citrate) on the general progress of embryogenesis. For this purpose, 60 rats were randomly divided into three groups: control, experimental group with cadmium chloride exposure and experimental group with cadmium citrate exposure. Cadmium chloride solvent, cadmium citrate solvent at a dose of 1.0 mg/kg and distilled intragastric water were injected from the first to the thirteenth (first subgroup) and from the first to the twentieth days of embryogenesis (second subgroup). When cadmium chloride was injected, total embryonic (by 4.24 and 3.67 times), pre-implantation (by 6.50 and 14.03 times) and post-implantation mortality (by 3.07 and 2.49 times) increased with a reduction of the number of surviving fetuses by 24.0% and 25.9% compared with the control group on the 13th and 20th days of embryogenesis respectively. At the same time, during exposure to cadmium citrate, indicators of total embryonic mortality increased by 4.02 and 3.52 times, pre-implantation mortality by 6.04 and 13.03 times, and post-implantation mortality by 3.09 and 2.26 times, and indicators of the number of live fetuses decreased by 18.3% and 22.2% in relation to the control group. When determining the accumulation of cadmium in embryos on the 20th day of gestation, polyelement analysis of biological materials using the atomic emission method with electric arc atomization revealed a 15.83-fold increase in cadmium chloride and 9.00 times in cadmium citrate relative to the control group. Embryolethality rates increased in animals of both experimental groups while the number of live fetuses per female decreased, which indicated an obvious embryotoxic effect of cadmium compounds. It is would be useful to conduct histological studies, which will help detect changes at the tissue level and possibly explain the level of embryonic mortality.
Contribution to the identification of medicinal plants used against COVID-19 in North-West Morocco
Authors: Laaribya S. , Alaoui A. , Azmi R.
Published: March 2023

The coronavirus disease 2019 (COVID-19) affects humans, who are now developing a milder form of the illness. In addition to the use of available drugs, the local populations in Morocco used medicinal plants during the pandemic. The current study aimed to document and to research the level of use of traditional medicine using plants in Morocco. Ethnobotanical surveys were conducted on the perceptions and level of use of plants through a case study in North-West Morocco. The methodology is based on targeted surveys, from April to September 2021, of households that have had cases if nfection with COVID-19. Five hundred surveys were randomly and systematically distributed in the study area to highlight the medicinal use of plants to treat COVID-19 and its consequences for health and well-being. The results showed the attachment of the populations to traditional medicine with the use of plants available in the study area (local forest area and herbalists). The 23 species used by the populations in question against COVD-19 belong to 12 families. The analysis shows the dominance of the Lamiaceae family with nine species, followed by Asteraceae with three species. The Lamiaceae family have proven marked performance in the fight against COVID-19. The results obtained offer orientations for the enhancement of the beneficial effects of traditional medicine and clinical trials remain to be carried out. The current results highlight that flora can be a source for the discovery of medicinal agents active against COVID-19.
Physicochemical quality indicators of honey: An evaluation in a Ukrainian socioecological gradient
Authors: Zhuk A. , Sytnikova I. , Fylypchuk T. , Bahlei O. , Shkrobanets O. , Danihlík J. , Moskalyk H. , Panchuk I. , Burkut V. , Angelstam P. , Fedoriak M.
Published: March 2023

Physical and chemical quality indicators of 65 polyfloral honey samples from three administrative districts of Chernivtsi region in South Western Ukraine were studied. The chosen administrative districts were Putyla (representing the ‘Traditional villages’ stratum), Storozhynets (the ‘Intermediate’ stratum) and Khotyn (the ‘Intensive agriculture’ stratum), which reflect a steep gradient of social and ecological conditions such as land cover and land use, level of economic development, culture and demography. The quality of honey was determined in accordance with the requirements of the Ukrainian national standard and the EU Directive relating to honey (or Codex Alimentarius Honey Standard) by using the following indicators: reducing sugars and moisture content, diastase activity, free acidity, pH, electrical conductivity, hydroxymethylfurfural (HMF) and proline content. The profile of carbohydrates was analyzed, in particular glucose, fructose, sucrose, maltose, trehalose, melezitose, raffinose. The ratio of fructose to glucose (F/G) was determined. All tested samples complied with the international standards for the mass fraction of reducing sugars, diastase activity and hydroxymethylfurfural content. For physical and chemical parameters, the studied honey samples were of high quality. The content of the reducing sugars in the honey samples varied within the range of 66.0–97.6%. The fructose content ranged from 342 to 549 mg/g, and the glucose content variation ranged within 283–517 mg/g. The average fructose/glucose ratio was 1.2 for honey samples from the three studied districts. Besides fructose and glucose, some oligosaccharides, such as maltose, trehalose and melezitose, were found in the examined honey. Melezitose was detected in the honey samples from ‘Traditional village’ (21 samples) and ‘Intermediate’ (5 samples) districts. The total variability of HMF content in the studied 65 honey samples from apiaries in the three districts of Chernivtsi region ranged from 0.19 to 30.8 mg/kg. The minimum moisture content was found to be 16.2% (in the ‘Traditional village’ and ‘Intermediate’ strata), and 22.2% was the maximum (in the ‘Intermediate’ stratum). Our studies have shown that free acidity of the samples varied within the range 13.5 to 58.0 meq/kg. Proline content variability for the three studied geographical areas ranged from 82.3 to 1201.2 mg/kg. The studied samples of honey had a low pH level (~ 3.7), high content of proline (~ 513 mg/kg) and reducing sugars (~ 80%), which indicates its nutritional value and naturalness. Deviations from the honey standards in moisture content, acidity and electrical conductivity was revealed in 8% to 10% of all samples.
The effect of the ryanodine receptor gene on the reproductive traits of Welsh sows
Authors: Zhukorskyi О. М. , Tsereniuk О. М. , Vashchenko P. А. , Khokhlov A. M. , Chereuta Y. V. , Akimov О. V. , Kryhina N. V.
Published: March 2023

The reproductive performance of sows largely determines the efficiency of the entire pig farming industry. The purpose of our work is the evaluation of polymorphism of the ryanodine receptor gene and its impact on the reproductive traits of sows of the Welsh breed of pigs. For this study, 148 pigs of the Welsh breed were used. The reproductive traits of sows were evaluated in two adjacent generations. We conducted a comprehensive assessment of the reproductive ability of sows using the SIRQS (selection index of reproductive qualities of sows), determined phenotypic consolidation coefficients and assessed the genetic potential of the animals’ productivity. The polymorphism of the RYR1 gene was determined using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). Data processing was performed using single-factor analysis of variance (ANOVA). Polymorphism of the ryanodine receptor gene in sows of the Welsh pig breed was evaluated. 8.0% of the animals were identified as carriers of the mutant allele of the RYR1 gene. However, no homozygous RYR1-nn animals were found. Pigs of the maternal generation carrying the homozygous NN genotype had better reproductive performance in all indicators. Sows that were carriers of the mutant allele were characterized by lower values of the genetic productivity potential compared with the entire estimated population for all productive traits. Sows which were free of the mutant allele of the RYR1 gene were characterized by large values of the SIRQS index. The values of the coefficients of phenotypic consolidation of the number of live born piglets in sows without the mutant allele were lower than in sows with the mutant allele n. Better performance of sows free of the mutant allele of the RYR1 gene was established over sows carrying it in all evaluated traits of reproductive capacity (for different traits P ranged from 0.021 to 1.0*10–4), except for number of piglets born alive per sow in the daughter generation. Sows with the NN genotype had better selection index values by 15.7% in the maternal generation and by 10.2% in the daughter generation. In order to increase the reproductive ability of sows in the studied population of Welsh pigs and achieve similar results in other herds of this breed, animals free from the mutant allele of the RYR1 gene should be selected for further reproduction in the process of breeding, while on the contrary, carriers of this gene should be gradually eliminated from the herd. To carry out breeding work, further research is needed on the entire population of Welsh pigs for the RYR1 gene.
Nitrogen-fixing, phosphate-potassium-mobilizing ability of Rahnella bacteria isolated from wheat roots
Authors: Shakirov Z. S. , Mamanazarova K. S. , Yakubov I. T. , Zakiryaeva S. I. , Khamidova K. M.
Published: March 2023

As the number of people on earth increases, so does the need for food. Providing the population with environmentally friendly agricultural food is one of the urgent problems of our time. Currently, the main direction of modern organic farming is the use of biofertilizers. Bacterial preparations are capable of influencing the physiological processes of plants in small quantities, leading to increase in plant productivity. The objective of this work was to study rhizobacteria associated with wheat roots. For this purpose, we took more than 100 isolates of rhizobacteria from the rhizosphere and root surface of wheat plants grown in irrigated fields of Tashkent, Syrdarya, Andijan, Kashkadarya regions. Rhizobacteria were grown on nutrient media of Döbereiner, Ashby, Pikovsky, and Zack, and 25 isolates of associative rhizobacteria were selected based on the characteristics of absorption of molecular nitrogen, mobilization of phosphorus and potassium. They actively dissolved Сa3(PO4)2 and KAlSiO4 for 3 days. They were found to produce organic acids. In organic farming, nitrogen-fixing, phosphorus- and potassium-mobilizing rhizobacteria are of great practical importance, while our experiments on obtaining biological products are considered as an environmentally friendly and cost-effective way to increase crop yields. From the surface of wheat roots grown in different zones of Uzbekistan, when screening for nitrogen fixation, we selected 3 isolates with acetylene reductase activity of 79–91 nmol C2H4/flacon/24h. We determined that bacteria completely mobilized phosphate, forming 100% acid when grown in a medium containing Ca3(PO4)2 for 5 days. The ability of the bacteria to mobilize potassium was studied on a nutrient KAlSiO4-containing medium. The bacteria were observed to mobilize potassium, forming 90–100% acid within 15 days. Based on the study of the 16S rRNA gene of bacteria, we identified rhizobacteria UT3, UT4, and UT9 as Rahnella aquatilis.
Bioclimatic projection of the ecological niche of curly mallow (Malva verticillata) based on the forecast of the dynamics of the geographical range in the context of global climate change
Authors: Panchenko K.
Published: March 2023

Curly mallow (Malva verticillata L.) is a promising species for cultivation to obtain valuable compounds for the application in medicine, and this species can be used in the bioenergy system to provide industry with alternative energy sources. For the highest economic efficiency, the practical use of this species requires the development of complex measures related to both agrotechnologies and selective breeding. Such measures require resources and there is an urgent problem of assessing the prospects of such investments taking into account the global climate change. Therefore, the problem that we aimed to solve was the assessment of how the global climate change would impact the curly mallow in general in the global context, as well as in the conditions of Ukraine in the next 50–70 years. The database of the Global Biodiversity Information Facility (GBIF) contains 2,104 records of curly-leaved mallow. This species is found on all the continents except Antarctica. Asia accounts for 39.1% of the species’ range, Europe – 53.3%, Africa – 3.6%, North America – 3.2%, South America – 0.1%, Australia – 0.8%. The modelling of M. verticillata response to the climatic factors showed that the best response models were V (in 31.6% of cases) and VII (in 36.8% of cases). Model V characterizes unimodal bell-shaped asymmetric response, and model VII – bimodal asymmetric response. The species response to the mean annual temperature is asymmetric bell-shaped with a shift to the right. The optimal average annual temperature for this species is 9.1 °C. Comparing the distribution of available resources and their use is the basis for identifying the features of the ecological niche of the species. The MaxEnt approach indicates that Southeast Asia and Europe have the most favourable conditions for the existence of this species. Changes in the climatic conditions over the next 50–70 years will make the conditions for the life of M. verticillata in the southern hemisphere unfavourable, and the favourable conditions for it in the northern hemisphere will shift significantly to the north. At the same time, conditions in the autochthonous range of the species will become unfavourable. Obviously, if not for the significant potential of the species to disperse, it would have died out as a result of the significant climate change. The area where favourable conditions for the species will remain unchanged is Central Europe. Conditions in Eastern Europe, including Ukraine, will moderately improve. The results indicate the perspective of the cultivation of curly mallow in Ukraine in the future.
Effect of liposomal drug based on interferon and extract from Silybum marianum on antioxidative status of bulls against the background of contamination of fodders by cadmium and plumbum
Authors: Gutyj B. V. , Martyshuk T. V. , Parchenko V. V. , Kaplaushenko A. H. , Bushueva I. V. , Hariv I. I. , Bilash Y. P. , Brygadyrenko V. V. , Turko Y. I. , Radzykhovskyi M. L.
Published: March 2023

The balance between anti- and prooxidants in animal organisms in general and in each cell in particular is responsible for the regulation of many metabolic processes that provide immunocompetence, growth, development and protection of animals from oxidative stress, related to inflow of cadmium and plumbum. Therefore, the objective of our study was the influence of a liposomal drug based on interferon and milk thistle (Silybum marianum (L.) Gaertn.) on the antioxidative status of the organism of bulls in the conditions of cadmium and plumbum loading. The experiments were performed on six-months-old Black Motley dairy cattle. The fodders in the farm were determined to contain high levels of plumbum and cadmium. The liposomal drug Lipointersyl inhibited the lipid peroxidation processes in the bulls. The drug components promoted the decrease in the level of intermediate and end products of lipid peroxidation, in particular 22% decrease in the level of diene conjugates and 20% decrease in TBA-active products. Intramuscular injection of the liposomal drug to bulls of the experimental group strengthened the antioxidant protection of their organism. On the 30th day of the experiment, blood from experimental group animals was seen to have a 9.8% increase in reduced glutathione. Assay of the enzymatic link of the glutathione system revealed that the activity of glutathione peroxidase and glutathione reductase in the blood of the animals that had been injected the liposomal drug Lipointensyl had increased by 24.0% and 27.7% respectively by the 30th day of the experiment. The experiments conducted on young cattle demonstrated that intermuscularly injected the Lipointensyl liposomal drug – against the background of cadmium and plumbum loading – promoted the activation of the glutathione system of antioxidant protection as a result of increase in the activity of its enzymatic and non-enzymatic links. The study of catalase and superoxide dismutase activities revealed that on the 30th and 40th days of the experiment, the activity of those enzymes varied within the physiological norms. Therefore, the analyzed Silybum marianum-based liposomal drug has antioxidant properties, it is recommended for young cattle in the conditions of contamination with heavy metals in order to prevent the development of oxidative stress.
Аntibiotic resistance of bacterial cultures isolated from the feral pigeon (Columba livia) and starling (Sturnus vulgaris) at a solid waste landfill
Authors: Dementieieva Y. Y. , Muzyka N. , Muzyka D. , Chaplygina A. B.
Published: March 2023

Resistance to antibiotics is well-known global phenomenon. There are places contributing to the development of antibiotic resistance such as waste landfills, especially ones that accept medical waste which did not undergo disinfection and livestock waste with bacteria not sensitive to antibiotics. An extensive system of transfer of antibiotic resistant microorganisms is formed on these territories (zoochory, groundwater, transport etc.). The aim of the research was to determine the species composition of bacteria isolated from birds of Derhachi municipal solid waste landfills in Kharkiv city, Ukraine. Also, we determine the sensitivity of bacterial isolates to a number of standard antibiotic drugs. We collected droppings of feral pigeons (Columba livia Gmelin, 1789; Columbidae) and starlings (Sturnus vulgaris Linnaeus, 1758; Sturnidae) during the winter period in 2020/2021; both species are dominants of waste landfills. We isolated 15 bacteria species of 4 families by bacteriological methods (growing on simple and selective media and identification by biochemical properties): Enterobacteriaceae (Enterobacter asburiae, E. dissolvens, E. cancerogenus, E. cloacae, E. sakazakii, Escherichia coli, Klebsiella terrigena, K. ornithinolytica, Citrobacter freundii, Proteus mirabilis), Yersiniaceae (Serratia ficaria, S. rubidaea, S. entomophila), Morganellaceae (Providencia stuartii) and Pseudomonadaceaе (Pseudomonas aeruginosa). Sensitivity was determined by the disk-diffusion method to 18 antibiotics. Ten isolates turned out to be multiresistant-resistant to three or more classes of antimicrobial drugs. A promising direction for future research is the determination of the pathogenicity of the isolates and checking the roles of birds of Derhachi solid waste landfills as reservoirs of pathogens. Currently, it can be assumed that large concentrations of synanthropic birds (especially those that forage on solid waste landfills) with a high probability are reservoirs of many bacteria, in particular those that have developed resistance to drugs.
Amharic Folkloric Oral Traditions: Collections for Insiders and for Outsiders
Authors: Unseth Peter , Ze'amanuel Bitania
Published: March 2023

The two books of Amharic proverbs and the book of Amharic riddles under review document Amharic oral traditions far beyond what others have done previously. They all build on previous scholarship. In addition, each one adds new examples to what has been published before. But it is also important to note that each book has added significant new methodological contributions to their field. They will be valued by those who use and enjoy Amharic oral traditions in their lives. They will also be valued by scholars who study these Amharic oral traditions. In addition, these books can serve as inspirations and models for speakers of other languages, in the Horn and beyond.
Verena Krebs, Medieval Ethiopian Kingship, Craft, and Diplomacy with Latin Europe
Authors: Kelly Samantha
Published: March 2023

Review
Derib Ado, Almaz Wasse Gelagay, Janne Bondi Johannessen, eds, Grammatical and Sociolinguistic Aspects of Ethiopian Languages
Authors: Bulakh Maria
Published: March 2023

Review
Josef Tropper and Rebecca Hasselbach-Andee, Classical Ethiopic: A Grammar of Geˁez, Including Sample Texts and a Glossary
Authors: Priess Maija
Published: March 2023

Review
Disputed Translations from The Life and Struggles of Our Mother Walatta Petros (2015) Reconsidered: Some Notes on Gǝʿǝz Philology
Authors: Kleiner Michael
Published: March 2023

The present article was prompted by Yirga Gelaw Woldeyes’s ‘Colonial Rewriting of African History: Misinterpretations and Distortions in Belcher and Kleiner’s Life and Struggles of Walatta Petros’ as published in a special issue of the Journal of Afroasiatic Languages, History and Culture in the fall of 2020. Yirga’s text of more than eighty pages is a wide-ranging and often acrimonious critique of Wendy Laura Belcher’s and my scholarship in our 2015 annotated translation of the Gädlä Wälättä Ṗeṭros. This reply does not attempt to address all the philological and non-philological issues Yirga raises. Rather, it focuses on refuting Yirga’s allegations of sexualizing mistranslations on our part. As these alleged mistranslations form the virtually exclusive basis for Yirga’s more far-reaching accusations against our scholarship, refuting them also collapses his broader case.
A Handlist of Illustrated Early Solomonic Manuscripts in German Public Collections
Authors: Dege-Müller Sophia , Gnisci Jacopo , Pisani Vitagrazia
Published: March 2023

Illustrated manuscripts in the Ethiopic language, as material objects that carry textual and visual information, are among the most valuable sources of data for art historians specializing in this area. This article provides a handlist of illustrated early Solomonic manuscripts housed in German libraries and museums. The contribution was created within the framework of the AHRC-DFG project Demarginalizing medieval Africa: Images, texts, and identity in early Solomonic Ethiopia (1270–1527) so our data reflects the project’s research focus on visual matter. This is the first time that the illuminations of the manuscripts included in the handlist are analysed comprehensively. We believe that the resulting work sheds new light on the history of book illustration in early Solomonic Ethiopia and hope that it will provide researchers with a valuable instrument to foster comparative research and a more integrative approach to the study of Ethiopian art.
Evaluation of neural models’ linguistic competence: evidence from Russian predicate agreement
Authors: Studenikina Kseniia Andreevna
Published: March 2023

This study investigates the linguistic competence of modern language models. Artificial neural networks demonstrate high quality in many natural language processing tasks. However, their implicit grammar knowledge remains unstudied. The ability to judge a sentence as grammatical or ungrammatical is regarded as key property of human’s linguistic competence. We suppose that language models’ grammar knowledge also occurs in their ability to judge the grammaticality of a sentence. In order to test neural networks’ linguistic competence, we probe their acquisition of number predicate agreement in Russian. A dataset consisted of artificially generated grammatical and ungrammatical sentences was created to train the language models. Automatic sentence generation allows us to test the acquisition of particular language phenomenon, to detach from vocabulary and pragmatic differences. We use transfer learning of pre-trained neural networks. The results show that all the considered models demonstrate high accuracy and Matthew's correlation coefficient values which can be attributed to successful acquisition of predicate agreement rules. The classification quality is reduced for sentences with inanimate nouns which show nominative-accusative case syncretism. The complexity of the syntactic structure turns out to be significant for Russian models and a model for Slavic languages, but it does not affect the errors distribution of multilingual models.
Detection of uses of disposed resources in C\# source code using static analysis
Authors: Tsiazhkorob Uljana Vladimirovna , Ignatyev Valery Nikolayevich , Belevantsev Andrey Andreevich
Published: March 2023

The paper is devoted to the scalable approach for the detection of uses of disposed resources in C# source code, that is based on static symbolic execution. The resulting detector is implemented as a part of an industrial SharpChecker, that performs a scalable inter-procedural path-, and context-sensitive analysis. The evaluation of the developed detector shows 70% true positive ratio allowing it to include to the standard set of detectors and provide functionality to users. The paper describes a detection algorithm that takes into account the limitations imposed by the existing infrastructure of SharpChecker, its evaluation on the set of open-source programs containing 6 mln LOC and some examples of found errors in real projects.
DEGREE OF SUSCEPTIBILITY TO PERSUASION PRINCIPLES IN ADVERTISING: MEASURING THE PERSUASION PRINCIPLES AS PART OF ADVERTISING INFLUENCE
Authors: Spasova L.
Published: March 2023

The present investigation has two aims: 1) to investigate the susceptibility of consumers to persuasion principles of Cialdidni and 2) to identify which of the principles achieves a high effect of advertising impact on different consumers. The instrument used was the adapted and modified STPS questionnaire developed by Kaptein el at., as well as the respondents' subjective judgments of the extent to which the advertisements affected based on the persuasion principles. The results of t-tests indicate that the principle of liking affects persuasion statistically significantly less than the application of all other principles for the whole sample, and through correlation analysis it is found that the principle of social proof is susceptible to the presence of influence from others three principles. Susceptibility to persuasion, achieved through the following principles: reciprocity, commitment and consistency, liking and unity, is statistically significantly higher in women due to its high sensitivity than in men, which confirms the results of other researchers.
Mélyen infiltráló colorectalis endometriosis laparoszkópos kezelésével szerzett tízéves tapasztalataink
Authors: Miklós Dominika , Dobó Noémi , Csibi Noémi , Brubel Réka , Szabó Gábor , Ács Nándor , Bokor Attila
Published: March 2023

Bevezetés: Mélyen infiltráló endometriosis esetén a laesiók több
mint 5 mm mélyen infiltrálják a peritonealis felszínt. Bélérintettség a
páciensek 3–37%-ában fordul elő. Célkitűzés: A szerzők a
bélendometriosis miatt végzett műtétek során szerzett tapasztalataikat mutatják
be. Módszer: 2009 és 2020 között 675 páciens esett át
bélreszekción belet érintő, mélyen infiltráló endometriosis miatt a Semmelweis
Egyetem Szülészeti és Nőgyógyászati Klinikájának Baross utcai részlegén. Négy
különböző műtéti technika került alkalmazásra: „shaving”, discoid, szegmentális
és NOSE-reszekció (természetes testszájadékon keresztül végzett
specimeneltávolítás). Eredmények: 182 esetben „shaving”-et, 93
esetben discoid reszekciót, 130 esetben NOSE-technikát, illetve 270 esetben
hagyományos szegmentális bélreszekciót alkalmaztunk. 40 esetben ultramély
anastomosist készítettünk. A műtéti idő medián értéke 85 perc volt, a
legrövidebb beavatkozás 25 percig, a leghosszabb 585 percig tartott. Az első 10
bélműtét átlagos műtéti ideje 260 (± 161,3) perc, az utolsó 10 műtété 114 (±
47,0) perc volt. Az átlagos vérveszteség 10 (± 20,3) ml, az átlagos kórházi
tartózkodás pedig 6 (± 2,3) nap volt. Súlyos sebészeti szövődmény (Clavien–Dindo
III. vagy súlyosabb) 18 esetben alakult ki. Összesen 17 esetben alakítottunk ki
sigmoideo-, illetve ileostomát. Laparotomiás konverzióra 6 esetben volt szükség.
Megbeszélés: Intézményünkben ugyanaz a team végezte a
beavatkozásokat, ami az egyes sebészek technikája helyett a műtéti technikák
eredményességét mutathatja. A műtétek szövődményrátája tapasztalt sebészi team
esetén nem nagy, a műtéti idő az elvégzett műtétek számával arányosan,
szignifikánsan csökken. Következtetés: A belet érintő, mélyen
infiltráló endometriosis biztonságosan és hatékonyan kezelhető mind a
konzervatív megközelítésnek tekinthető „shaving” vagy discoid, mind a
radikálisabb megközelítésként számontartott hagyományos szegmentális vagy
NOSE-reszekcióval. Orv Hetil. 2023; 164(9): 348–354.
Gépi perfúzió a vesetranszplantációban
Authors: Tóth Fruzsina , Szijártó Attila , Piros László
Published: March 2023

A szervtranszplantáció területén évek óta fennálló probléma az egyre növekvő szervigény mellett az elérhető donorszervek számának stagnálása. Az ellentét feloldására tett kísérletek több irányból közelítették meg a kérdést: egyrészről a donorkritériumok kiterjesztésével, másrészt az eltávolított szervek minőségének megőrzésére kidolgozott gépi perfúzió módszerével, melynek használata bizonyítottan csökkenti a késve meginduló graftműködés előfordulását, és javítja a grafttúlélést. Ezek az előnyök különösen a kiterjesztett kritériumú donáció tekintetében kifejezettek. A vesetranszplantáció során egyre szélesebb körben alkalmazzák a gépi perfúziót; jelenleg a legelterjedtebb formája a hypothermiás gépi perfúzió, azonban egyre több érv szól a normothermiás eljárás mellett is. Az alkalmazott modalitástól függően nemcsak szervkonzerválásra, de szervkondicionálásra is van lehetőség. Napjainkban számos kutatás folyik a gépi perfúzió során alkalmazható terápiás lehetőségekről, melyek a jövőben fontos szerepet játszhatnak az ischaemia-reperfúziós károsodás és az immunizáció csökkentésében. Közleményünkben a kiterjesztett kritériumú donáció rövid áttekintését követően összefoglaljuk a gépi perfúzió alkalmazási módjait, aktuális eredményeit, valamint diagnosztikus és terápiás lehetőségeit a vesetranszplantáció területén. Orv Hetil. 2023; 164(9): 339–347.
Kihívás a hepatitis C-vírus-elimináció korában: miért van szükség a HCV elleni vakcinációra?
Authors: Pár Alajos
Published: March 2023

A hepatitis C-vírus (HCV) az egyik leggyakoribb oka a krónikus májbetegségnek,
amely cirrhosishoz, hepatocellularis carcinomához, májtranszplantációhoz
vezethet. A nagy hatékonyságú, direkt ható antivirális szerek bevezetése és
sikere a HCV terápiájában optimizmust keltett a vírus globális eradikációjának
lehetőségét tekintve. Az Egészségügyi Világszervezet célul tűzte ki az új
vírushepatitis-esetek számának 90%-os csökkentését 2030-ra. Kiderült azonban,
hogy a HCV-fertőzöttek nagy száma, a szűrések elégtelensége és a kezelésekhez
való hozzáférés problémái miatt ez a cél egyedül az antivirális terápiával nem
érhető el, csak ha az vakcinációval társul. A dolgozat áttekinti a HCV-infekció
virológiai és immunológiai jellemzőit mint a vakcináció alapját és lehetőségét.
Tárgyaljuk a potenciális vakcinák típusait és a hatékonyság értékelésére
szolgáló eljárásokat. Az egészséges önkénteseken kipróbált kontrollált humán
infekció modell HCV-infekcióban a direkt ható antivirális szereknek köszönhetően
alkalmazható. Az újabb kutatási eredmények alapján várható, hogy az évtized
végére megoldódhat a HCV-elimináció korának kihívása, a vakcináció. Orv Hetil.
2023; 164(9): 322–331.
Platin desensitizations in thoracic malignancies and risk factors for breakthrough reactions
Authors: Köycü Buhari Gözde , Koca Kalkan İlkay , Ateş Hale , Nazik Bahçecioğlu Sakine , Demir Şenay , Yeşilkaya Selma , Vural Solak Gürgün Tuğçe , Aksu Kurtuluş , Öner Erkekol Ferda
Published: March 2023

Although platin desensitization is a safe and effective alternative for patients with hypersensitivity reactions (HSRs), sometimes breakthrough reactions (BTRs) can be encountered. However, data about the risk factors for BTRs are limited. The aim of this study is to define the outcomes of desensitization, the characteristics of BTRs, and to identify the risk factors for BTRs with platins in thoracic malignancies. This is a retrospective report of patients with thoracic malignancies who underwent platin desensitization. Patients’ demographics, initial HSR characteristics, skin test results, desensitization outcomes, and BTR characteristics were recorded. Thirty-three lung cancer and 14 malignant pleural mesothelioma (MPM) patients were included in the study. The culprit drug was cisplatin in 29 and was carboplatin in 18 patients. Skin test positivity was 43.5% with cisplatin, 50% with carboplatin, and it was found to be higher if the interval between the initial HSR and skin testing (ST) was ˃20 days (p = 0.027). One hundred and five desensitization courses were performed. Twenty-two patients had 33 BTRs. Skin test positivity was higher in the BTR-positive group (p = 0.025). BTRs (18.2%; n = 6) were more severe than initial HSR. In the case of epinephrine administration during initial HSR, epinephrine administration during the first BTR was found to be more (p = 0.036). The target dose was achieved in 92.4% of desensitization courses. The number of previous platin infusions ≥10 was found to be an independent risk factor for BTR development (p = 0.036 OR:17.641, 95% CI: 1.211–256.971). Identification of risk factors for BTR will guide appropriate management and desensitization approaches for platin HSRs.
PADRÃO DE HIDRATAÇÃO E QUALIDADE FISIOLÓGICA DAS SEMENTES DE CHIA
Authors: Karnopp Klaus Vargas , Bortolotto Rafael Pivotto , Koefender Jana , Zamberlan João Fernando , Salazar Rodrigo Fernando dos Santos , Camera Juliane Nicolodi , Souto Kelen Muller , Schoffel André
Published: March 2023

O padrão de hidratação associado à qualidade fisiológica das sementes pode ser um indicativo para avaliação da qualidade. O objetivo foi verificar a relação existente entre o comportamento da curva de hidratação de sementes de chia e sua qualidade fisiológica. O experimento foi conduzido em delineamento inteiramente casualizado com 4 repetições. Foram utilizadas sementes de chia (Salvia hispanica L.) divididas em quatro lotes de diferentes qualidades fisiológicas, diferenciados pelos envelhecimentos artificiais por diferentes períodos, inicialmente submetidos a testes para caracterizar o potencial fisiológico dos lotes: germinação, primeira contagem de germinação, envelhecimento acelerado, frio sem terra, curva de hidratação. A qualidade fisiológica afeta o teor de água absorvido pelas sementes de chia durante a hidratação. Sementes de chia com maior vigor apresentam menor velocidade de hidratação.
ATIVIDADE DIDÁTICA DE ANÁLISE DO LANÇAMENTO DE FOGUETE DE GARRAFA PET UTILIZANDO PROCESSAMENTO DIGITAL DE IMAGENS
Authors: Souza Gustavo Fontoura
Published: March 2023

Este artigo visa relatar o desenvolvimento do trabalho realizado no IFRN envolvendo alunos de ensino médio que construíram um foguete de garrafas PET e realizaram a filmagem do processo de lançamento para analisar e modelar o lançamento. Inicialmente era apenas uma alternativa para o processo de medição do alcance do lançamento que é feito manualmente, contudo após a realização do processo, muitos outros elementos puderam ser estimados, como velocidade inicial e altura máxima. Os resultados da segmentação da posição do foguete em cada frame das imagens da filmagem pode ser obtida e realizou-se duas regressões com vistas a estimar um modelo para a trajetória do foguete. Este trabalho propiciou o aprofundamento do aprendizado dos alunos a cerca do tema em questão.
Explicit formulae for Chern-Simons invariants of the hyperbolic J(2n,-2m) knot orbifolds
Authors: Ham Ji-Young , Lee Joongul
Published: March 2023

We calculate the Chern-Simons invariants of the hyperbolic double twist knot orbifolds using the Schläfli formula for the generalized Chern-Simons function on the family of cone-manifold structures of double twist knots.
Topological structure of optimal flows on the Girl's surface
Authors: Prishlyak Alexandr , Loseva Maria
Published: March 2023

We investigate the topological structure of flows on the Girl's surface which is one of two possible immersions of the projective plane in three-dimensional space with one triple point of self-intersection. First, we describe the cellular structure of the Boy's and Girl's surfaces and prove that there are unique images of the project plane in the form of a $2$-disk, in which the opposite points of the boundary are identified and this boundary belongs to the preimage of the $1$-skeleton of the surface. Second, we describe three structures of flows with one fixed point and no separatrices on the Girl's surface and prove that there are no other such flows. Third, we prove that Morse-Smale flows and they alone are structurally stable on the Boy's and Girl's surfaces. Fourth, we find all possible structures of optimal Morse-Smale flows on the Girl's surface. Fifth, we obtain a classification of Morse-Smale flows on the projective plane immersed on the Girl's surface. And finally, we describe the isotopic classes of these flows.
Quasiconformal mappings and curvatures on metric measure spaces
Authors: Deng Jialong
Published: March 2023

In an attempt to develop higher-dimensional quasiconformal mappings on metric measure spaces with curvature conditions, i.e. from Ahlfors to Alexandrov, we show that for n≥2 a noncollapsed RCD(0,n) space with Euclidean volume growth is an n-Loewner space and satisfies the infinitesimal-to-global principle.
Merch-products and merchandise-activity as objects of civil rights in the impression economy
Authors:   Penza State University, Likhter Pavel L.
Published: March 2023

Today, such objects of civil legal relations, such as merch-products (stylized clothing, attributes) and merchandise-activity, are becoming increasingly important, that is, visiting thematic parks, quests and other activities, allowing you to plunge into the world of your favorite films and books. Consumers are not enough to receive standardized goods, they need impressions that meet their unique aesthetic and cultural preferences. The article discusses the legal aspects of the phenomenon of fan activity and related issues of protection of intellectual rights. According to the resuits of the article, the urgency of the doctrine of fair use is noted, according to which the free dissemination of the results of intellectual activity during merchandis activity is allowed, if it contributes to the development of arts and cultural progress. Currently, however, neither the Civil Code of the Russian Federation nor any other applicable regulation mentions concepts referring to merch or merchandise. Disputes relating to fan activity are governed by the general principles of civil law as well as by the provisions of Part 4 of the Russian Civil Code dealing with copyright or trademark protection. For example, according to Article 1482 of the Civil Code of the Russian Federation, verbal, pictorial, volumetric and other designations may be registered as trademarks. Accordingly, under Russian law, local producers of confectionery products may also be sued for selling cakes with an image of Cinderella or Bambi by representatives of the rights holder of the relevant trademark. However, the application of the general provisions of the Civil Code to obligations arising from such unique objects of civil legal relations as children's parties, quests, participation in theme camps, role-playing games or other merchandising activities has certain peculiarities. The protection of exclusive rights in these markets must take into account the goals of stimulating innovation and cultural and technological progress. In our country, the three-step test is partly enshrined in Part 5 of Article 1229 of the Civil Code of the Russian Federation, according to which the use of the results of intellectual activity is allowed without the consent of the right holders if it does not cause unjustified damage to the ordinary use of intellectual property or otherwise infringe upon the legitimate interests of the right holders. In addition, Article 1274 of the Civil Code permits free use of the work for informational, scientific, educational or cultural purposes. Consequently, merchandising activity cannot be recognised as infringing the interests of right holders because, based on the systematic interpretation of Articles 1229 and 1274 of the Civil Code of the Russian Federation, a fan reworking does not displace the original work from circulation. The author declares no conflicts of interests.