bluuebunny/crossref_metadata_2025 huggingface dataset:
Deciphering Sex-Specific Genetic Architectures Using Local Bayesian Regressions
Authors: Funkhouser Scott A , Vazquez Ana I , Steibel Juan P , Ernst Catherine W , los Campos Gustavo de
Published: March 2020

Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (G×S) interactions remains a challenge likely because the magnitude of such an interaction is typically and exceedingly small; traditional genome-wide association techniques may be underpowered to detect such events, due partly to the burden of multiple test correction. Here, we developed a local Bayesian regression (LBR) method to estimate sex-specific SNP marker effects after fully accounting for local linkage-disequilibrium (LD) patterns. This enabled us to infer sex-specific effects and G×S interactions either at the single SNP level, or by aggregating the effects of multiple SNPs to make inferences at the level of small LD-based regions. Using simulations in which there was imperfect LD between SNPs and causal variants, we showed that aggregating sex-specific marker effects with LBR provides improved power and resolution to detect G×S interactions over traditional single-SNP-based tests. When using LBR to analyze traits from the UK Biobank, we detected a relatively large G×S interaction impacting bone mineral density within ABO, and replicated many previously detected large-magnitude G×S interactions impacting waist-to-hip ratio. We also discovered many new G×S interactions impacting such traits as height and body mass index (BMI) within regions of the genome where both male- and female-specific effects explain a small proportion of phenotypic variance (R2 < 1 × 10−4), but are enriched in known expression quantitative trait loci.
Transformational Leadership Style and Talent Retention in Pakistani Banks: A Serial Multiple Mediation Model
Authors: Mir Muhammad Masood , Khan Abdullah , Abbas Qamar
Published: March 2020

The objective of this research was to determine factors that mediate between transformational leadership style and retention of employees, as talent retention is an emerging issue for organizations due to workplace diversity. This study provides a guideline to the supervisors and leaders in managing their workforce. By using structural equation modeling (SEM), the result exhibited a positive impact between transformational leadership and talent retention, transformational leadership and job satisfaction, transformational leadership, and psychological ownership. The study also revealed a positive impact on job satisfaction and talent retention, psychological ownership, and talent retention. This model is an attempt to find out the further factors and measures that affect employee retention in the banking sector of Pakistan.JEL Classification: J28, J54, G21How to Cite:Mir, M. M., Khan, A., & Abbas, Q. (2020). Transformational Leadership Style and Talent Retention in PakistaniBanks: A Serial Multiple Mediation Model. Etikonomi: Jurnal Ekonomi, 19(1), 63 – 76. https://doi.org/10.15408/etk.v19i1.11264.
The Determinants of Indonesian Textile’s and Clothing Export to the Five Countries of Export Destination
Authors: Irvansyah Faizal , Siregar Hermanto , Novianti Tanti
Published: March 2020

Indonesian textile and clothing products (TPT) is the second-largest export product after oil palm product. There are five biggest export destination countries, that is the United States, Japan, South Korea, and Turkey. This study aims to analyze the factors that affect TPT exports to the five biggest export destination countries. The factors that affect TPT exports examined by using time series and panel data analysis. Using panel data analysis finds that GDP per capita of the destination country, the exchange rate of the Rupiah, the price of textiles in the destination country, and import tariffs stipulate in the destination country affect TPT exports. Then, using time series analysis finds that GDP per capita and import tariffs affected TPT export to the United States, China, and Turkey. Meanwhile, the factors influencing Indonesian textile exports to Japan and South Korea are textile prices, rupiah exchange rates, and import tariffs.JEL Classification: F14, F43How to Cite:Irvansyah, F., Siregar, H., & Novianti, T. (2020). The Determinants of Indonesian Textile’s and Clothing Export to the Five Countries of Export Destination. Etikonomi: Jurnal Ekonomi, 19(1), 19 – 30. https://doi.org/10.15408/etk.v19i1.14845.
Abusive Head Trauma in Infants and Children
Authors: Narang Sandeep K. , Fingarson Amanda , Lukefahr James ,   COUNCIL ON CHILD ABUSE AND NEGLECT, Sirotnak Andrew P. , Flaherty Emalee G. , Gavril CAPT Amy R. , Hoffert Gilmartin Amanda Bird , Haney Suzanne B. , Idzerda Sheila M. , Laskey Antoinette , Legano Lori A. , Messner Stephen A. , Mohr Bethany , Moles Rebecca L. , Nienow Shalon , Palusci Vincent J.
Published: March 2020

Abusive head trauma (AHT) remains a significant cause of morbidity and mortality in the pediatric population, especially in young infants. In the past decade, advancements in research have refined medical understanding of the epidemiological, clinical, biomechanical, and pathologic factors comprising the diagnosis, thereby enhancing clinical detection of a challenging diagnostic entity. Failure to recognize AHT and respond appropriately at any step in the process, from medical diagnosis to child protection and legal decision-making, can place children at risk. The American Academy of Pediatrics revises the 2009 policy statement on AHT to incorporate the growing body of knowledge on the topic. Although this statement incorporates some of that growing body of knowledge, it is not a comprehensive exposition of the science. This statement aims to provide pediatric practitioners with general guidance on a complex subject. The Academy recommends that pediatric practitioners remain vigilant for the signs and symptoms of AHT, conduct thorough medical evaluations, consult with pediatric medical subspecialists when necessary, and embrace the challenges and need for strong advocacy on the subject.
On a nonlocal boundary value problem with an oblique derivative
Authors: Nazarova Kulzina Zh. , Turmetov Batirkhan Kh. , Usmanov Kairat Id.
Published: March 2020

The work studies the solvability of a nonlocal boundary value problem for the Laplace equation. The nonlocal condition is introduced using transformations in the Rn space carried out by some orthogonal matrices. Examples and properties of such matrices are given. To study the main problem, an auxiliary nonlocal Dirichlet-type problem for the Laplace equation is first solved. This problem is reduced to a vector equation whose elements are the solutions of the classical Dirichlet probem. Under certain conditions for the boundary condition coefficients, theorems on uniqueness and existence of a solution to a problem of Dirichlet type are proved. For this solution an integral representation is also obtained, which is a generalization of the classical Poisson integral. Further, the main problem is reduced to solving a non-local Dirichlet-type problem. Theorems on existence and uniqueness of a solution to the problem under consideration are proved. Using well-known statements about solutions of a boundary value problem with an oblique derivative for the classical Laplace equation, exact orders of smoothness of a problem's solution are found. Examples are also given of the cases where the theorem conditions are not fulfilled. In these cases the solution is not unique.
The Main Trends in the Development of Production and Consumption of Fish Products in the Sakhalin Region
Authors: Pitilyak Dmitry A. , Karyakina Irina E. , Zakharchenko Diana A.
Published: March 2020

Introduction. The study is of relevance as there has been a decrease in catch over the past few years in the Sakhalin Region. This decline must be assessed in terms of its impact on the economic performance of enterprises and household budgets in the region. The objective of this study is to analyze and evaluate the trends in the development of production and consumption of fish products in the Sakhalin Region.

Materials and Methods. The study has analyzed data from the Federal State Statistics Service and the Unified Interdepartmental Statistical Information System on the production and consumption of fish products in the Sakhalin Region. The graphical and comparative methods have been used, which made it possible to compare the dynamics of production and consumption of fish products as well as to show that the transfer of production trends to the consumer market has a disproportionately marginal impact.

Results. The contradictory results of the development of the industry have been revealed: while there has been a decrease in the number of organizations operating in the industry, the number of personnel involved in processing, the volume of production and sales of canned fish, there has been an increase in the profitability of sales and prices for delicious seafood. The negative fact is that consumption of fish products has reduced in the Sakhalin Region, fish products ranking only 7th (by mass) in the total diet. The identified imbalances and negative trends in the production of fish products have also indirectly transferred to the sphere of consumption.

Discussion and Conclusion. In the Sakhalin Region, one of the leading fishing regions in Russia, the conditions for satisfying the corresponding demand have not been fully created, especially in terms of affordable prices for fish products in the market that do not overcome the inertia of slowly growing incomes. The scientific and practical significance of the research materials consists in the comprehensive nature of the study on the processes of production and consumption of fish products.
Esthetic Perception of the Smile According to Variation of the Vertical Position and the Angulation of the Upper Central Incisor in Three Regions of Peru
Authors: García-Gonzales Luis Angel , Evaristo-Chiyong Teresa Angélica
Published: March 2020

Objective: To evaluate the esthetic perception of the smile according to the variation of the vertical position and the angulation of the upper central incisor (UPI) by dental students (DS) and common people (CP) of three regions of Peru. Materials and Methods: Descriptive cross-sectional design. The sample was 462 adults, divided into 77 for each subgroup of DS and CP of the Lima (Coast), Junín (Highlands) and Loreto (Rainforest) regions. Using the Photoshop® software, a photograph of a woman's smile was modified by varying the vertical position and angulation of the UPI, obtaining images that were evaluated using the analog visual scale. Results: The CP rated better than DS in most categories (p <0.001). The smile best valued by DS in a vertical position was 1mm and 2mm; and for angulation 0°, while for CP 1mm and 0° respectively (p <0.05). Comparing by regions, the DS of Lima gave the lowest rating for 0 ° with 52.63 and those of Junín the highest for 4° with 45.90. The PC of Loreto registered the lowest score for the vertical position categories (p <0.001), while for angulation in Junín it was rated with a lower score than in Loreto for -6 ° and 0 °; and for 4° Lima provided the lowest rating (p <0.001). Conclusions: The esthetic perception of the smile is affected by the variation of vertical position and angulation of the ICS in common people and dental students in the three regions of Peru.
On the Pólya-Szegö operator inequality
Authors: DİNH Trung Hoa , MORADI Hamid Reza , SABABHEH Mohammad
Published: March 2020

In this paper, we present generalized Pólya-Szegö type inequalities for positive invertible operators on a Hilbert space for arbitrary operator means between the arithmetic and the harmonic means. As applications, we present operator Grüss, Diaz–Metcalf, and Klamkin–McLenaghan inequalities.****************************************************************************************************************************************************************************************************************************************************
Integrating suitability for teaching into an electronic health record - A novel and versatile tool for medical education
Authors: Singh Himanshu , Thomson Yvonne , Paladugu Madhavi , Wood Nick , Woywodt Alexander
Published: March 2020

This article was migrated. The article was marked as recommended. The educational literature has noted the implications of electronic health records (EHR) for patient care and discussed various implications for the learner-teacher relationship but it has so far not viewed EHR as an educational tool. We wondered whether we could use EHR to facilitate undergraduate medical students' exposure to hospital in-patients with an interesting history or findings on clinical examination. As clinicians, we encounter such patients on a regular basis during ward rounds and referrals but students are often absent during these encounters, leading to a loss of learning opportunities. Our aim was therefore to harness the EHR and create an electronic "flag" that would, following consent, document suitable inpatients and thus maximise the students' exposure to patients who present learning opportunities. With help from our IT department we developed a simple add on to our existing EHR that allows any clinician to electronically highlight and document such patients during inpatient encounters. A member of the educational faculty can, whenever required, interrogate the EHR for the presence of inpatients with interesting findings on examination in the hospital and facilitate contact with our medical students. We report details of our approach, describe early experience and potential pitfalls and suggest future applications.
Relação entre oferta de diagnóstico e tratamento da sífilis na atenção básica sobre a incidência de sífilis gestacional e congênita
Authors: Figueiredo Daniela Cristina Moreira Marculino de , Figueiredo Alexandre Medeiros de , Souza Tanise Kely Bezerra de , Tavares Graziela , Vianna Rodrigo Pinheiro de Toledo
Published: March 2020

Resumo: O Brasil tem registrado aumento nas incidências de sífilis gestacional e congênita, revelando-se como um importante problema de saúde pública no país. O trabalho teve como objetivo analisar a relação entre as ofertas de diagnóstico e tratamento da sífilis na atenção básica e as incidências de sífilis gestacional e congênita. Foi realizado estudo ecológico analisando as incidências desses agravos e a cobertura de ações diagnósticas e terapêuticas na atenção básica. A amostra do estudo foi composta por municípios com população acima de 20.000 habitantes, com cobertura da atenção básica superior a 50% e nos quais a maioria das equipes foi avaliada no segundo ciclo do Programa de Melhoria do Acesso e da Qualidade na Atenção Básica. Para analisar a efetividade das ações de detecção e tratamento foi desenvolvido o Índice de Variação da Transmissão Vertical de Sífilis. A administração da penicilina e a realização de teste rápido nesses municípios obtiveram medianas iguais a 41,9% e 67,14%, respectivamente, com diferenças regionais. A mediana da incidência de sífilis gestacional foi 6,24 (IIQ: 2,63-10,99) em municípios com maior oferta de teste rápido, e de 3,82 (IIQ: 0,00-8,21) naqueles com oferta inferior, apontando aumento na capacidade de detecção. Municípios com redução da transmissão vertical apresentavam maiores medianas dos percentuais de equipes com oferta dos testes rápidos (83,33%; IIQ: 50,00-100,00) e realização de penicilina (50,00%; IIQ: 11,10-87,50), demonstrando relação entre estas ações e a redução de sífilis congênita. Os achados indicam a necessidade de ampliação dessas ofertas e reforça a importância na redução da transmissão vertical.
Agência local e indução federal: a operação da política municipal de habitação em Recife e Curitiba
Authors: Lavalle Adrian Gurza , Rodrigues Maira , Guicheney Hellen
Published: March 2020

RESUMO Introdução: O artigo explora a implementação da política nacional de construção de moradias para segmentos de baixa renda no plano local. Estudamos o Programa Minha Casa Minha Vida (PMCMV) em Recife e em Curitiba entre 2003-2012. Apesar de ser uma política federal, há variações locais baseadas nas possibilidades de escolha das administrações municipais. Materiais e Métodos: Foram feitas entrevistas com gestores e informantes-chave, além de análise documental. Resultados: A operação da política habitacional nas duas capitais é diferente em função do processo de institucionalização e das capacidades administrativas desses municípios. Em Recife, com uma política setorial ainda pouco institucionalizada e capacidades mais limitadas, a política federal de habitação moldou a política local. O Programa foi positivamente avaliado pelos gestores municipais da área. Já em Curitiba, com uma trajetória de institucionalização mais sólida e maiores capacidades instaladas, a política federal foi adaptada à lógica de divisão de trabalho previamente existente entre os órgãos municipais. Os agentes locais, diferentemente, foram críticos em relação ao PMCMV. Discussão: O artigo faz um contraponto à literatura internacional sobre governança e descentralização e à literatura nacional sobre federalismo e descentralização, que destacam a ausência de autonomia decisória no plano local. Conclui-se que é preciso atentar para o caráter contingente da relação entre descentralização e autonomia decisória, já que a implementação de políticas públicas traz consigo certo grau de discricionariedade. O caso do PMCMV mostra que existe espaço para as escolhas locais mesmo no caso de políticas nacionalmente centralizadas.
Effect of feeding crude or treated tung meal (Aleurites fordii) in the diet of Rhamdia quelen on growth, digestive enzymes and biochemical parameters
Authors: Pretto Alexandra , Silva Leila Picolli da , Corrêia Viviani , Martinelli Suziane Ghedini
Published: March 2020

Abstract This study evaluated the addition of tung (Aleurites fordii) meal to the feed of Rhamdia quelen, as an alternative to animal protein sources. Silver catfish juveniles were fed different diets which included crude tung meal, chemically treated tung meal and a control without tung meal. The chemical treatment was based on the sequential application of acid and alcohol solutions and reduced the phytic acid from 1.63 to 0.61% and condensed tannin content from 0.025 to 0.018%. The nutritional response of fish to these ingredients was evaluated over nine weeks, based on growth performance, digestive enzyme activity and biochemical responses. After nine weeks, the diet containing crude tung meal caused reduced growth (weight: -57.9%; total length: -21.09%; specific growth rate: -99.74%). This diet also reduced acid protease and lipase activities, decreased concentrations of glucose, cholesterol and triglycerides in plasma and decreased liver glycogen and glucose concentrations. However, after nine weeks, fish fed with treated tung meal showed higher growth (weight, total length and specific growth rate similar to control) and reduced metabolic changes, possibly due to the removal of antinutrients and toxic substances. At the 32% level of inclusion, the chemically treated tung meal can be considered an alternative protein source for silver catfish.
Analysis of a training program for older workers in the use of technology: difficulties and satisfaction
Authors: Raymundo Taiuani Marquine , Castro Carla da Silva Santana
Published: March 2020

Abstract Objective: To analyze the potential of individualized training in the use of technology in the work environment as well as the satisfaction of workers with such training. Method: A quantitative, descriptive, interventional and longitudinal study was performed. Workers aged 50 and over, who performed any type of work activity and who had difficulties using technology participated. The following instruments were used for data collection: a socioeconomic questionnaire, a questionnaire about the technology used in the work environment and difficulties with its use and a scale to evaluate user satisfaction with training. The training sessions used the Client-Centered Practice approach. The data were analyzed by means of descriptive statistics and compared using the McNemar test. Results: A total of 30 workers participated in the study (15 men and 15 women), who were aged between 50 and 75 years and had a mean age of 63.3 years (±7.89). The participants had the most difficulty using computers, cell phones, the internet, email and recording and playback devices. After the training, participants exhibited significantly less difficulty in using cell phones (p-value<0.01), computers (p-value<0.01), copiers (p-value=0.03), the internet (p-value=0.04), e-mail (p-value=0.02) and recording and playback devices (p-value=0.04). They were satisfied with the training program, the instructor and with their own performance. Conclusion: The results of the present study indicate the potential of individualized training focused on the needs and interests of older workers so that they can perform work activities involving technology with autonomy and independence.
Evaluation of different methodologies for the determination of phenolic compounds in tropical fruits
Authors: Guimarães Karina Carvalho , Salgado Derlyene Lucas , Carvalho Elisângela Elena Nunes
Published: March 2020

Abstract Phenolic compounds are natural antioxidants and can be found with abundance in fruits and vegetables. One of the first methods created for analyzing phenolic compounds was the Folin-Denis method; and hereafter, the Folin Ciocalteu method was developed and recently, one of the most recent method is the Fast Blue. Due to the importance of these compounds in food, this work aimed to determine the total phenolic compounds in three fruits, such as: Passion Fruit, “Palmer” mango and “Pera” orange. In addition, these fruits were analyzed through three different determination methods. Furthermore, the content of vitamin C, soluble solids, titratable acidity and pH of these fruits were evaluated. Based on the results, it was verified that there was no difference among the values of vitamin C, soluble solids and TA in relation to those found in the literature. When comparing the three methods (Fast Blue BB, Folin-Ciocalteu Reagent and Folin-Denis Reagent), the results showed a difference in the phenolic compounds that may be related to the distinct reagents used in each method and its different action.
Drum drying process of jabuticaba pulp using corn starch as an additive
Authors: Nunes Larissa Peixoto , Ferrari Cristhiane Caroline , Ito Danielle , Souza Elaine de Cássia Guerreiro , Germer Silvia Pimentel Marconi
Published: March 2020

Abstract Jabuticaba is a fruit native to Brazil, appreciated for its flavor and is also very nutritious, but it is a seasonal fruit and highly perishable. Therefore, drying is a good alternative for its conservation. The purpose of this work was to use drum drying to obtain jabuticaba flakes using corn starch as the main carrier agent. The sorption isotherm of the flakes at 25 °C was also studied, as well as the determination of the critical storage condition and the estimation of product shelf life through the permeability of different packages to the water vapor using mathematical models. The drum drying conditions were: temperature of 144 °C; residence time of 18 seconds; addition of 20% (dry basis) of corn starch and 0.5% (d.b.) of glyceryl monostearate. The final product was analyzed with respect to its physicochemical and technological properties. The sorption isotherm of the flakes was determined at 25 °C, using the gravimetric method with saturated solutions (0.11 ≤ aw ≤ 0.84). After the process, the flakes presented good retention of anthocyanins and total phenolic compounds, besides a high antioxidant activity. The water solubility of the product was around 70% and the hygroscopicity was approximately 24%. The equilibrium experimental points of the isotherm were better adjusted by the GAB model, with a monolayer moisture value of 12.74% (w.b) and a critical aw of 0.432.
Orthodontic management of a non-syndromic patient with concomitant bimaxillary hypohyperdontia: a case report
Authors: Hlaing Ei Ei Hsu , Ishihara Yoshihito , Fujisawa Atsuro , Yamashiro Takashi , Kamioka Hiroshi
Published: March 2020

ABSTRACT Introduction: Tooth agenesis is one of the most common dental anomalies; however, the concomitant occurrence of opposite dental numerical variation of hypohyperdontia is extremely rare. Objective: To report the successful orthodontic management of a patient with non-syndromic concomitant bilateral agenesis of mandibular canines and two midline inverted supernumerary maxillary teeth. Case report: 21-year-old female patient with a chief complaint of protrusive right maxillary central incisor. The patient was diagnosed with a mild Class II skeletal base, Angle Class III molar relationship and increased overjet associated with hypohyperdontia. Anterior open bite accompanied with tongue-thrusting habit were also observed. Two temporary anchorage devices (TADs) were implanted at the buccal side of the maxillary molar region to control vertical height. Anterior teeth retraction was done after extraction of the maxillary first premolars, to improve the excessive overjet. The treatment mechanics involved lingual brackets system for the maxillary arch and transpalatal arch for anchorage control. Results: The total active treatment period was 35 months. Acceptable occlusion with increased bite force and contact area as well as functional excursion were established without interference, following complex orthodontic treatment with premolar substitution. The resultant occlusion and a satisfactory facial profile were maintained after 29 months of retention. Conclusion: The present case report provides implications regarding the orthodontic treatment of hypohyperdontia-associated substitution for missing teeth as an effective option for improving aesthetic and functional aspects.
Impact of catastrophizing on pain during orthodontic treatment
Authors: Costa Eduardo Oliveira da , Blagitz Marco Nassar , Normando David
Published: March 2020

ABSTRACT Objective: This study proposed to investigate the influence of catastrophizing and others factors related to pain during orthodontic treatment. Methods: 27 patients with 0.022 x 0.028-in Straight-wire brackets were evaluated during alignment and leveling phase with nickel-titanium wires. Visual Analog Scales measured the intensity of orthodontic pain at six moments after a clinical appointment: 6 first hours; 1, 2, 3, 5, and 7 days. Multiple linear regression and stepwise approach assessed the influence of the following variables on pain: catastrophizing, sex, age, duration of treatment, clinical appointment time (morning or afternoon), and wire diameter. Results: The highest pain intensity was reported 24 hours after activation. These data were used to analyze factors associated with pain level. Age (r = 0.062, p= 0.7586), sex (p= 0.28), catastrophizing (r = -0.268, p= 0.1765), and orthodontic wire diameter (r = 0.0245, p= 0.2181) were not correlated with orthodontic pain in the univariate statistics. Catastrophizing was included in the multiple regression model because it was of great interest. Duration of orthodontic treatment (r = 0.6045, p= 0.0008) and the time when orthodontic appliance was activated (p= 0.0106) showed statistical significant associations with pain, and were also included in the multivariate regression, which showed that about 32% of orthodontic pain could be explained by the duration of treatment (R2= 0.32, p= 0.0475). Catastrophizing (R2= 0.0006, p= 0.8881) and clinical appointment time were not significantly associated with pain (R2= 0.037, p= 0.2710). Conclusions: Pain after activation of fixed orthodontic appliance is not associated with catastrophizing as well as age, sex, orthodontic wire diameter, and period of activation.
“Descansar e dormir sem riscos”: o Jornal do Médico (Portugal) e o desastre da talidomida, 1960-1962
Authors: Leandro José Augusto
Published: March 2020

Resumo O artigo analisa como o periódico Jornal do Médico, editado na cidade do Porto, em Portugal, divulgou o desastre da talidomida. A pesquisa percorreu as páginas da fonte desde o início de 1960 até o final de 1962. Aqui, objetivam-se apontar e discutir duas questões interligadas: a morosidade em publicar matérias sobre os efeitos deletérios do medicamento, vendido no país sob a denominação Softenon®, e a construção discursiva da isenção da responsabilidade do médico no fenômeno da iatrogenia medicamentosa.
A psicanálise e as transformações na concepção da infância nas crônicas e colunas de Clarice Lispector, 1952-1973
Authors: Josiowicz Alejandra
Published: March 2020

Resumo O artigo estuda o papel da psicologia na transformação dos modos de conceber a infância nas décadas de 1950 a 1970, tendo como foco as colunas e crônicas publicadas em revistas e jornais de ampla circulação por Clarice Lispector entre 1952 e 1973. Delas emerge um novo paradigma que considera os filhos mistérios psicológicos no interior do âmbito doméstico, objeto de investigação por parte da mãe, e que entende a infância como núcleo do psiquismo adulto. Trata-se de um modelo biopsicológico, que combina a preocupação higiênica pela saúde física com uma atenção psicológica à subjetividade infantil, no qual a criança das classes médias emerge como índice do questionamento dos papéis de autoridade familiar e da nova centralidade do indivíduo.
“Uma dádiva das marés”: os estudos sobre manguezais da cientista Marta Vannucci em sua trajetória internacional, 1969-1989
Authors: Varela Alex Gonçalves
Published: March 2020

Resumo Marta Vannucci é considerada uma das mais importantes cientistas brasileiras. O artigo explora a trajetória internacional da pesquisadora, destacando sua atuação na Organização das Nações Unidas para a Educação, a Ciência e a Cultura (Unesco) no âmbito do projeto regional sobre mangues na Ásia e no Pacífico. Produto da sua atuação nesse programa, a autora publicou Os manguezais e nós, que é objeto de análise crítica neste artigo.
La ética y la medicina social: la perspectiva de Michel Foucault
Authors: Fernández Agis Domingo
Published: March 2020

Resumen La preocupación de Michel Foucault por la medicina, su historia y su impacto en la sociedad, es una constante en su obra. El objetivo de este trabajo es contrastar el contenido de las conferencias que Foucault impartió en Río de Janeiro, en octubre de 1974, con los materiales preparatorios de las mismas que forman parte de los fondos adquiridos por la Biblioteca Nacional de Francia. Una de las cuestiones clave en dichas conferencias es la relación entre la ética y la medicina social contemporánea. Esa cuestión, analizada desde el punto de vista de Foucault, constituye el trasfondo e interés último del presente trabajo.
Uma carta que veio das minas: natureza e mineração do ouro na mobilização de preceitos morais e políticos no século XVIII
Authors: Capanema Carolina Marotta
Published: March 2020

Resumo O artigo analisa, a partir de documento inédito, a “Carta que veio das minas”, de 1727, como os conceitos de natureza e mineração foram utilizados para mobilizar preceitos morais e políticos na construção de uma interpretação sobre Minas Gerais. Em um primeiro momento, analisam-se o documento e suas convenções, de forma comparativa com outros escritos setecentistas. Em seguida, a partir da análise do enredo da carta, discute-se o uso simbólico da natureza e da mineração na construção de um discurso negativo das Minas que, por fim, é associado a um sentido regulador, que denuncia práticas abusivas de grupos de grande representatividade naquela sociedade: os magistrados e letrados.
Hitupmã’ax: educação intercultural e atendimento diferenciado à saúde do povo maxakali
Authors: Cordeiro Gabriela Oliveira Gomes , Barra Cynthia de Cássia Santos , Silva Francismary Alves da
Published: March 2020

Resumo Este trabalho analisou um artefato (um livro de saúde) concebido pelo povo maxakali, denominado Hitupmã’ax: curar (2008). Tangenciado o projeto de produção do livro, o objetivo foi entender o processo de negociação da saúde pública no Brasil, dentro de uma perspectiva histórica e intercultural das epistemologias não ocidentais. Constatamos que a construção da obra maxakali representa um esforço para diminuir a distância da percepção e dos cuidados de saúde entre indígenas e não indígenas, e por essa via demonstramos a importância desse projeto intercultural para a efetivação de políticas públicas voltadas para o público indígena em geral e, especificamenete, para a promoção da história, dos saberes e da cultura maxakali.
Ingredientes de um prato exótico: saúde e alimentação em pauta no primeiro Congresso Médico Amazônico (Belém, 1939)
Authors: Miranda Aristóteles Guilliod de , Abreu Jr José Maria de Castro , Muniz Érico Silva
Published: March 2020

Resumo O artigo apresenta o contexto de organização e realização do primeiro Congresso Médico Amazônico, ocorrido na cidade de Belém, em agosto de 1939. Inserido na tradição da divulgação científica de seu tempo, o evento reuniu parte das elites médicas da região e contou com a participação de convidados reconhecidos nacional e internacionalmente, entre eles Josué de Castro e Dante Costa. Tendo como principais fontes os materiais impressos produzidos pelo congresso e as notícias veiculadas nos jornais paraenses, este texto examina a concentração de debates sobre as carências alimentares da Amazônia observando a compreensão acadêmica e política das faces do fenômeno para a região.
A mulher, o médico e as historiadoras: um ensaio historiográfico sobre a história das mulheres, da medicina e do gênero
Authors: Martins Ana Paula Vosne
Published: March 2020

Resumo O artigo realiza um balanço historiográfico parcial sobre um campo de estudos prolífico e heterogêneo, a história das mulheres, da ciência e da medicina, articulado politicamente com o feminismo e de autoria majoritariamente feminina. Pretende apresentar as principais correntes desse campo que se constitui e consolida na segunda metade do século XX, como o contexto histórico de sua produção, definição de temas, referências teóricas, fontes e problemas de pesquisa. Tendo em vista sua extensão, o artigo concentrou-se na produção bibliográfica em língua inglesa, destacando as diferenças de abordagens e as contribuições teóricas e metodológicas mais expressivas.
A cochonilha no mundo luso-brasileiro: o manuscrito setecentista editado por Manuel Joaquim Henriques de Paiva
Authors: Santos Clara Braz dos , Pereira Milena da Silveira
Published: March 2020

Resumo O documento que o leitor encontrará a seguir é a transcrição inédita e modernizada do manuscrito História do descobrimento da cochonilha no Brasil, editado pelo médico e químico Manuel Joaquim Henriques de Paiva entre os anos de 1774 e 1801. O propósito de Paiva, com essa versão revista e anotada do estudo pioneiro de seu irmão, o médico José Henriques Ferreira, era estimular a cultura e o comércio da cochonilha, um inseto produtor de corante avermelhado muito requisitado na Europa. A História..., portanto, fornece indícios do papel capital dos saberes ditos científicos para o fomento e engrandecimento do Reino português e de sua principal colônia.
Great Western railway electrification, UK: collectively delivering a sustainability strategy
Authors: Deschamps Emmanuel , Franklin Mike
Published: March 2020

Through collaborative working, staff engagement, grassroots input, culture change and leadership support, the Greater West Programme rose to the challenge of ‘delivering environmental benefits and sustainable outcomes to the highest industry standard’, with the strong belief that ‘environmental protection and sustainable development are everyone’s business’. The programme developed and implemented initiatives that are leading the way in the industry, such as biodiversity no net loss based on good practice principles of biodiversity offsetting. The programme introduced sustainable construction solutions on its sites such as solar energy production as an alternative to diesel generators. It also encouraged innovative construction methods to minimise import of aggregates and associated lorry movements, and to maximise their reuse at demobilisation stage. The programme engaged with thousands of lineside neighbours and local stakeholders to minimise the impact of the works and leave a long-lasting legacy by funding biodiversity projects, taking part in volunteering, fundraising for local charities and inspiring the next generation to consider engineering within the rail industry as a career path.
Biodiversity net gain: civil engineers need to leave nature better than they found it
Authors: Machin Niall
Published: March 2020

Civil engineers will soon need to improve the biodiversity of their sites in England by at least 10%. Niall Machin of Waterman Infrastructure and Environment introduces the ‘biodiversity net gain’ provisions of new environmental legislation currently going through Parliament.
Civil engineers encouraged to get involved in an initiative to rewild western Europe
Authors: Jepson Paul
Published: March 2020

Rewilding advocates published an invitation to civil engineers and other professions last November to help upgrade Europe’s significantly damaged ecosystems. Paul Jepson of UK environmental consultancy Ecosulis says the profession is vital to successful rewilding.
Valencia portakalında Phyllocoptruta oleivora (Ashmead) (Acari: Phyllocoptidae)’nın meyve kalitesine etkisi
Authors: SATAR Serdar , TİRİNG Gülsevim , TUSUN Adnan , YEŞİLOĞLU Turgut
Published: March 2020

Phyllocoptruta oleivora (Ashmead) (Acari:
Phyllocoptidae) dünyanın nemli bölgelerinde turunçgillerin ciddi bir
zararlısıdır. Bu zararlı meyve verim ve kalitesinde kayıplara sebep
olabilmektedir. Bu çalışmada P. oleivora’nın Valencia portakalı meyve kalite
özelliklerine olan etkisi Adana ekolojik koşullarında araştırılmıştır. Bu
sebepten dolayı P. oleivora ile
bulaşık olan ve olmayan meyveler ağaçlardan toplanarak P. oleivora’nın zararının
varlığına ve yokluğuna göre sınıflandırmıştır. Meyveler 1: Bronz olmayan, 2:
Hafif bronz, 3: bronz ve 4: Yoğun bronz olarak kategorilere ayrılmıştır. Bu
çalışma sonucunda, meyve yüzeyinde geniş lekeler bulunan meyvelerin normal
meyvelerden titredilebilir asit oranı (%) ve Suda Çözülebilir Kuru Madde
Oranının (SÇKM,%) daha yüksek; usare miktarı (%), kabuk kalınlığı ve SÇKM/asit
oranının ise daha düşük olduğu saptanmıştır. Çekirdek sayısı, dilim sayısı ve
meyve indeksine ait regresyon katsayılarının diğer meyve kalite özelliklerinden
oldukça düşük olduğu belirlenmiştir.  Ayrıca.
yoğun popülasyon zararı sonucu dördüncü kategoriye giren meyvelerde, meyvelerin
normal meyvelerden %16 daha küçük olduğu, çekirdek sayısının da sıfır olduğu
tespit edilmiştir.
Penile agenesis: a case report
Authors: TARAKÇI Nuriye , KONAK Murat , YILMAZ Fatma Hilal
Published: March 2020

Penile agenesis is a rarely seen congenital anomaly with dramatic psychological outcomes. In more than half of the patients, other genitourinary anomalies can accompany penile agenesis. We herein present a newborn with rectovesical fistula associated with vesicoureteral fistula.
PLOSONE v1
Authors: Bae Sung-Jin
Published: March 2020

Abstract Background This study investigated the efficacy of first-generation (cefazolin) and third-generation (ceftizoxime) prophylactic antibiotics in patients undergoing cardiac surgery and the incidence of surgical site infections, hospital stay lengths, and medical costs. Methods All adult patients (≥20 years) undergoing cardiac surgery (coronary artery bypass surgery, valve operation, or combined surgery) at one hospital from January 01, 2009 to December 31, 2016 were included in this study. A single prophylactic antibiotic was administered at a dose of 1 g within 1 hour of surgical incision and for three days after surgery at eight-hour intervals. After the propensity score matching, 194 patients in each antibiotic prophylaxis groups (first-generation vs third-generation) were analyzed. Among the 388 patients, the incidence of surgical site infection were compared according to the type of prophylactic antibiotics and risk factors were evaluated by chi-squared tests followed by multivariate logistic regression analysis. A Student’s t-tests were analyzed to compare hospitalization and medical costs. Results The incidence of deep surgical site infections significantly lower in first-generation group (5.7%) than third-generation group (16.5%). The pathogens isolated from surgical infection sites were similarly distributed in both groups, but gram-positive bacteria were more highly infectious than gram-negative bacteria (67% vs 23%). Preoperative hospitalization duration, mean operation time, and ventilator use time were similar in both groups but the postoperative hospitalization duration was significantly shorter in the first-generation group (25.5 days) than third-generation (29.8 days). In addition, the medical cost lower in the first-generation group (20,594 USD) than third-generation (26,488 USD). Conclusion In conclusion, the first-generation (cefazolin) is better than the third-generation (ceftizoxime) as a prophylactic antibiotic in reducing surgical site infection rates, hospitalization lengths, and medical expenditures.
PLOSONE folder v1
Authors: Bae Sung-Jin , Kim Inah , Song Jaechul , Chung Euy-Suk
Published: March 2020

Abstract Background This study investigated the efficacy of first-generation (cefazolin) and third-generation (ceftizoxime) prophylactic antibiotics in patients undergoing cardiac surgery and the incidence of surgical site infections, hospital stay lengths, and medical costs. Methods All adult patients (≥20 years) undergoing cardiac surgery (coronary artery bypass surgery, valve operation, or combined surgery) at one hospital from January 01, 2009 to December 31, 2016 were included in this study. A single prophylactic antibiotic was administered at a dose of 1 g within 1 hour of surgical incision and for three days after surgery at eight-hour intervals. After the propensity score matching, 194 patients in each antibiotic prophylaxis groups (first-generation vs third-generation) were analyzed. Among the 388 patients, the incidence of surgical site infection were compared according to the type of prophylactic antibiotics and risk factors were evaluated by chi-squared tests followed by multivariate logistic regression analysis. A Student’s t-tests were analyzed to compare hospitalization and medical costs. Results The incidence of deep surgical site infections significantly lower in first-generation group (5.7%) than third-generation group (16.5%). The pathogens isolated from surgical infection sites were similarly distributed in both groups, but gram-positive bacteria were more highly infectious than gram-negative bacteria (67% vs 23%). Preoperative hospitalization duration, mean operation time, and ventilator use time were similar in both groups but the postoperative hospitalization duration was significantly shorter in the first-generation group (25.5 days) than third-generation (29.8 days). In addition, the medical cost lower in the first-generation group (20,594 USD) than third-generation (26,488 USD). Conclusion In conclusion, the first-generation (cefazolin) is better than the third-generation (ceftizoxime) as a prophylactic antibiotic in reducing surgical site infection rates, hospitalization lengths, and medical expenditures.
Viral Sequencing, from Gunk to Graph v1
Authors: A Eccles David
Published: March 2020

This is a fast "gunk to graph" protocol for analysing viral RNA from nasopharyngeal swabs. The approach involves swab lysis and inactivation at the point of sampling, uses a cellulose binding / wash protocol to reduce extraction cost, incorporates sample-specific barcodes during first-strand synthesis, nanopore rapid-attachment primers during PCR amplification, and nanopore sequencing with parallel RAMPART analysis for fast assembly and phylogenetics.
PLOSone submit v1
Authors: Bae Sung-Jin , Kim Inah , Song Jaechul , Chung Euy-Suk
Published: March 2020

Fig 1. Selection of study subjects and the propensity score matching process. We reviewed the medical records of 539 individuals. After propensity score matching, 388 patients remained in the final analysis.
İŞLETMELERİN DİJİTAL DÖNÜŞÜM SENARYOLARI - KAVRAMSAL BİR MODEL ÖNERİSİ
Authors: Klein Müge
Published: March 2020

Son yıllarda, büyük veri, sensörler, bulut bilişim, sosyal medya vs. gibi dijital teknolojilerin mümkün kıldıkları ile gündeme gelen dijital dönüşüm, tüm dünya ekonomisini ve bunun içinde yer alan işletmeleri yakından etkilemektedir. İşletmelerin günümüze kadar yaşadıkları dijitalleşme deneyimlerinden daha kapsamlı bir dijitalleşme anlamına gelen dijital dönüşüm, işletmelerin süreçlerinde, iş modellerinde, müşteri ilişkilerinde ve tüm örgütsel işleyiş ve yapılarında yıkıcı değişikliklere yol açmaktadır. İşletmelerdeki bu yıkıcı değişikliğin yönetilmesi için kapsamlı bir dijital dönüşüm stratejisi geliştirilmeli ve bir yol haritası çizilmelidir. Dijital dönüşüm konusu yeni bir araştırma alanı olduğu için standart bir tanıma ve standart özelliklere sahip olmadığı gibi, işletmeler de, farklı teknolojiler kullanarak farklı şekillerde ve birbirinden kopuk dijital dönüşümler gerçekleştirmektedirler. Dijital dönüşüm yol haritası, bir işletmenin gerçekleştirmeyi amaçladığı her türlü dijital dönüşüm şeklini kapsamalı ve farklı dönüşüm şekilleri arasındaki bağlantıyı göz ardı etmemelidir. Mevcut dijital dönüşüm yol haritaları veya süreç modelleri işletmelerdeki dijital dönüşümü ya çok genel olarak ele almakta, ya da sadece tek bir dijital dönüşüm senaryosuna odaklanmaktadır. Bu çalışmanın amacı bu eksikliği kapatmak ve işletmelerdeki farklı dijital dönüşüm senaryolarını belirleyerek işletmelerin kapsamlı dijital dönüşüm stratejisi belirlemelerine destek olmaktır. Çalışmada, kaynak araştırması ve örnek vakaların incelenmesi sonucu elde edilen bilgiler ışığında farklı dijital dönüşüm senaryolarını gösteren kavramsal bir model geliştirilecektir.
TÜRK VERGİ HUKUKU’NDA ANAYASAL İLKELER ÇERÇEVESİNDE ÖZEL USULSÜZLÜK KABAHATLERİ
Authors: Kaplan Nergis Feride
Published: March 2020

Devlet kamu hizmetlerinin finansmanı için vatandaşlardan cebri icra yoluyla vergi toplamaktadır. Devletin mali egemenliğinin bir görünümü niteliğinde olan vergilendirme yetkisiyle toplanan vergilerin zamanında ve gerçek tutarlarında ödenmesi kamu yararının sağlanması için oldukça önemlidir. Vergilendirme sürecinin birey ve devlet arasında sağlıklı seyredebilmesi için vergi hukuku alanında esasa ve şekle ilişkin kurallar getirilmiştir. Bilindiği gibi usule ilişkin kurallar esastan önce gelmektedir zira, esasın doğru uygulanabilmesi için usule ilişkin kuralların yerinde uygulanması gerekmektedir. Dolayısıyla vergilendirmenin sağlıklı yapılabilmesi için Vergi Usul Kanunu’nda düzenlenen usul kurallarına uyulmaması halinde bir usulsüzlük söz konusu olacaktır. Kabahat olarak kabul edilmesi sebebiyle özel usulsüzlük fiilleri VUK’nun yanı sıra 5326 sayılı Kabahatler Kanunu’nda uygulama alanı bulmaktadır.
Vergi usul hukukunda özel usulsüzlük fiilleri vergi kabahati olarak nitelendirilmiştir çünkü özel usulsüzlük fiilleri sonucunda uygulanacak yaptırımlar idari para cezası niteliğindedir. Bu çalışmada, usulsüzlük kavramından hareketle usulsüzlük fiillerinin suç ve kabahat ayrımı üzerinde durulmuş ve usulsüzlük çeşitlerinden olan özel usulsüzlük fiillerinin kavramsal mahiyeti ve bu fiillere ilişkin yaptırımlar tek tek ele alınarak mevcut yasal düzenlemeler ortaya konulmuştur.