bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating General Health and Related Factors Among Employed Women in Healthcare Staff: A Cross-sectional Study
Authors:   Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Khoshravesh Mandana , Pourmohsen Masoumeh ,   Department of Midwifery, School of Nursing and Midwifery, Rasht Branch, Islamic Azad University, Rasht, Iran., Khoshravesh Vahid ,   Department of Psychology, Faculty of Humanities, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran., Paksresht Sedigeh ,   Department of Obstetrics, Social Determinants of Health Research Center, Reproductive Health Research Center, Women Health Promotion, Community Health, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran., Kamranpour Bahareh ,   Department of Midwifery, School of Nursing and Midwifery, Rasht Branch, Islamic Azad University, Rasht, Iran.
Published: February 2022

Background: One of the main goals of healthcare systems is to maintain and promote women’s health. According to the literature, different factors, such as demographic characteristics, occupational status, stress, culture, and epidemics, can affect women’s health. This study aimed to determine the health status of employed women and its association with their demographic characteristics. Methods: This analytical, cross-sectional study was conducted on 325 women working in healthcare centers affiliated with Guilan University of Medical Sciences, Gilan Province, Iran, in 2019. After receiving their informed consent, the study subjects were chosen by random group sampling method. The study data were obtained using a General Health Questionnaire (GHQ). Data analysis was performed by the Chi-square test at a significant level of 0.05 in SPSS software, v. 23. Results: The Mean±SD age of the study women was 42.10±8.19 years, and 52.63% of them were nurses, 16.92% physicians, 19.39% midwives, and 11.7% health workers. Based on the present study results, 39.7% of the participants are suspected of having a health disorder or problem. According to the analysis, significant relationships were observed between women’s health and variables of age (P≤0.0001), level of education (P=0.03), occupational status of spouse (P≤0.0001), income level (P=0.02), and place of residence (P≤0.0001). Nevertheless, no significant association was found between women’s health and marital status and place of birth. Conclusion: Improving the health of healthcare staff requires special attention and appropriate supportive measures. Given the stressful conditions of healthcare staff, cognitive and behavioral interventions to improve work-life balance can enhance their performance regarding patient care while promoting their welfare.
The Effect of Long-term Exposure to Aspartame on Histomorphometric, Histochemical and Expression of P53, Bcl-2 and Caspase-3 Genes in the Ovaries of Mice
Authors:   Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Hosseini Mohsan , Morovvati Hassan ,   Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Anbara Hojat ,   Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Published: February 2022

Background and Objectives: Aspartame is a non-nutritive and artificial sweetener which is widely used in diet and low calorie products and also in a variety of foods, drugs and hygiene products. The present study has been conducted in order to evaluation of the effects of aspartame on ovaries in female mice. Methods: In this experimental study, 36 adult female mice were randomly divided into four groups of nine each. For three groups aspartame was administered orally with the doses of 40, 80 and 160 mg/kg.BW respectively, and one group as the control group received normal saline for 91 days by gavage. Also a control group was considered. 24 hours after the last treatment, ovarian tissue and blood samples were collected and used for biochemical, histomorphological, histomorphometric, histochemical and gene expression studies. The obtained data were analyzed using One-Way Analysis of Variance (ANOVA) and Tukey’s test at the significance level of P<0.05. Results: In ovarian histomorphometric studies, aspartame at a dose of 160 mg/kg significantly reduced growing follicles and significantly increased atresia follicles. Also in biochemical studies caused a significant decrease in TAC and a significant increase in MDA compared to control group. In connection with the studied genes, aspartame at a dose of 160 mg/kg caused a significant decrease in the expression of Bcl-2 gene and also a significant increase in the expression of P53 and Caspase-3 genes compared to the control group. Conclusion: It seems that high dose aspartame can cause adverse effects on histomorphology, histomorphometry and expression of P53, Bcl-2 and Caspase-3 genes in rat ovaries
Gestión de la cooperación Internacional: caso Observatorio de Comercio Exterior e Inversión Extranjera de la Universidad de Otavalo
Authors: Núñez Naranjo Edwin Santiago , Orbes Revelo Belky Nerea , González Alonso Jesús Francisco
Published: February 2022

Los fondos económicos provenientes de la cooperación internacional se han convertido en una herramienta de ayuda y en una fuente de financiamiento para organismos de investigación, ubicados en países en desarrollo que no disponen de los recursos necesarios para su funcionamiento. Su adjudicación y manejo ha sido un tema de interés para varios de estos órganos, entre ellos, el Observatorio de Comercio Exterior e Inversión Extranjera de la Universidad de Otavalo, que se ha esforzado por identificar, mediante la investigación, un  proceso viable que le permita acceder a fondos de organismos internacionales en una modalidad no reembolsable, como los ofrecidos por el Fondo Ítalo Ecuatoriano para el Desarrollo Sostenible (Fieds). La metodología del trabajo se circunscribió a un paradigma cualitativo y se centró en un nivel descriptivo; se desarrolló un análisis bibliográfico sobre la tipología y las modalidades de cooperación internacional existentes, y se aplicó tres instrumentos cualitativos de levantamiento de información de campo, entrevistas a expertos en el tema. Como principal resultado, se generó un mecanismo aplicable y replicable que garantice el acceso a montos económicos no reembolsables provenientes del extranjero, en particular del Fieds, para actividades de investigación en materia de comercio exterior e inversión extranjera. Este mecanismo se lo presenta en un flujograma descriptivo del proceso, que serviría de directriz para otros centros que requieran ayuda internacional.
Estrategias metodológicas innovadoras para la comprensión lectora
Authors: Guerrero Guerrero Héctor Ulpiano , Salvador Saráuz Patricia Lorena
Published: February 2022

Una de las dificultades más evidentes en los espacios educativos es la comprensión lectora y las estrategias metodológicas involucradas en el proceso, ya que afectan directamente al rendimiento académico de las y los estudiantes dejándolos desprovistos de una de las actividades sociales que mantiene al ser humano inmerso en la cultura, sociedad y medio en el que se desenvuelve y vive. La presente investigación, definida a partir de un enfoque cualitativo, pretende indagar en documentos científicos la forma en la que despliegan estrategias metodológicas innovadoras con el objetivo de mejorar las competencias de la comprensión lectora en las y los estudiantes. El estudio se realizó a partir de la búsqueda de información bibliográfica documental a través de un análisis cualitativo de la información; para ello, se seleccionaron los artículos más relevantes relacionados con el tema de estudio en los últimos 5 años, encontrados en motores de búsqueda como Publish or Perish 7 y Google Académico, así como en repositorios y bases de datos científicas como Redalyc, Scielo, Scopus y Dialnet. La revisión de los datos mostró que las estrategias activas, el uso de material multimedial y los nuevos límites de la educación son parte de las estrategias metodológicas innovadoras en las que la educación clásica unidireccional queda obsoleta ante la propuesta de una educación entendida como acto de participación social. Además, se identificó que la interacción educativa se define desde la participación y colaboración de todas y todos, con el fin de construir aprendices autónomos y libres en los procesos de generación de conocimiento. Se propone la redefinición de la idea de la educación a partir del uso de estrategias metodológicas innovadoras que han trascendido los límites tradicionales de la educación. Actividades, roles, evaluación, interacción son algunos de los factores reconocidos como resultados positivos en cuanto a la mejora de la comprensión lectora en las y los estudiantes. Estas estrategias innovadoras, aplicadas en varios niveles de formación, coinciden en que todo debe decantar en espacios participativos, colaborativos que propicien llevar la escuela a otros espacios en los que se aplique el conocimiento. El propósito del texto se plantea como el inicio de una discusión fundamental sobre la transformación de la estructura educativa.
On the Air: How a Rock ‘n’ Roll Radio Show Made Me a Better Librarian
Authors:   Georgia Institute of Technology, Bennett Charlie
Published: February 2022

Twelve years ago, I created a radio show with Ameet Doshi, my friend and colleague at the Georgia Tech library. We wanted to do a library talk show on the college radio station, but we wanted to have some fun, too, so we decided to play rock music in between the library talk. We called it Lost in the Stacks (LITS). I thought I was adding a little rock ‘n’ roll fun to my Fridays with a student outreach project; I did not understand that I was embarking on a creative and scholarly venture that would inform my professional practice and identity in every way.
PENGUKURAN USABILITY APLIKASI ZOOM MEETING SEBAGAI MEDIA E-LEARNING MENGGUNAKAN USE QUESTIONNAIRE
Authors: Fernanda Rachma Gea , Suryadi Edi , Ali M Sambas
Published: February 2022

Penelitian ini dilatar belakangi adanya penerapan social distancing yang mengharuskan mahasiswa melaksanakan kegiatan pembelajaran secara online dalam rangka mencegah penularan COVID-19. Pada saat pandemi COVID-19 membuat pengguna media e-learning meningkat pesat, hal tersebut membuat kebijakan work from home dari pemerintah sehingga seluruh kegiatan pembelajaran dikelas berganti menjadi pembelajaran online, termasuk di Universitas Negeri Jakarta. E-learning yang banyak digunakan sebagai media pembelajaran online adalah aplikasi zoom. Platfom ini mudah digunakan oleh pengguna laptop atau smartphone. Sebagai platfom yang banyak digunakan tentu perlu dilakukan pengukuran kebergunaan dari aplikasi zoom ini. Kebergunaan ini dapat diukur dari hasil presentase kelayakan yang diperoleh berdasarkan kuesioner yang disebarkan kepada pengguna. Pada penelitian ini kuesioner menggunakan metode use questionnaire berisi serangkaian pernyatan yang telah dikelompokan dalam beberapa aspek use yaitu ease of use (kemudahan pengguna), ease of learning (kemudahan belajar), satisfction (kepuasan), dan usefulness (kegunaan). Hasil yang diperoleh untuk setiap aspek usability yaitu aspek ease of use diperoleh kelayakan 86%, aspek ease of learning diperoleh kelayakan 74%, statisfaction diperoleh kelayakan 85%, dan easy of use diperoleh kelayakan 82%, berarti aplikasi zoom sangat layak digunakan oleh dosen karena apliaksi ini mudah digunakan, mudah dipelajari, memberikan kepuasaan dan berguna sebagai media e-learning di masa pandemi.
Linear Programming on Bread Production Using Uncertainty Approach
Authors: Wakili Adamu
Published: February 2022

Linear programming is applied to bread production and the raw materials for the research were collected from the bakery industry in Lokoja which were clearly identified. The paper took into account three types of bread with estimated profits and the problem was formulated from the collected data. The formulated problem was parameterized into parametric linear programming and run using the developed algorithm of linear programming The result obtained indicates that profit is made at d different values of the parameter,t, leaving the company the choice of any profit it wants to get.
Bodies In Architecture
Authors: Korotayeva Yekaterina
Published: February 2022

Throughout the history of Western architecture, the human body has been understood as a complete and singular thing. The collection of rules, texts, and theories that today we inherit as the system of architecture has been developed by mining ideal bodies for formal principles. This work is an attempt at engaging with the ongoing processes of redesign of our bodies and moving away from principles of biological determinism. Through the study of four imaginary and partial bodies this work re-frames the conception of a body as a multiplicity. The imaginary bodies, derived from the study of emerging surveillance technologies, social media, sexual desires, and neurological disorders, become the focus of the speculative design project of a home. As an assemblage of environments that only address imaginary dimensions of human condition, this thesis aims to relate to the emerging ways of being human that are often dismissed by established architectural regimes.
Towards a equitable approach to tackling the fare evasion problem: a scoping literature review and case study analysis
Authors: Cho Jessica
Published: February 2022

The widespread adoption of “proof-of-payment” ticketing systems by public transit corporations (PTCs) has renewed interest in the topic of fare evasion. Although this system has

many benefits, it has also been associated with higher rates of actual or perceived fare evasion. As such, many PTCs including the TTC in Toronto have also simultaneously invested in heightened measures to curb fare evasion. These measures, however, have usually taken the form of increased fines and policing, which have the potential to further disadvantage marginalized populations. A scoping literature review and case study analysis have been

employed to determine whether there is existing evidence that can make a case for the need for a more equitable solution to this problem, and to determine what alternative measures have been effective. Although there is much evidence to support the need for a more equitable approach, research into alternative measures is emerging and therefore somewhat inconclusive.
Inclusive city building: public engagement processes in the GTA
Authors: Grewal Taranjeet Kaur
Published: February 2022

Cities are changing yet planning policies are not keeping up with these changes. The migration of diverse individuals is a reality, yet planners are not considering how city building can be made more inclusive for these groups. This paper aims to answer the question, how can public engagement processes be more inclusive for immigrant and racialized communities? A literature review and analysis of policies for selected municipalities in the Greater Toronto Area is conducted and it is determined most policies and vision statements are too broad. The policies in place do not cater to immigrant and racialized groups however this can be rectified through creating engagement master plans and empowering the public to take part in the public planning process.
Analisa Perawatan Pompa Sentrifugal Intake B dengan Menggunakan Metode RCM di Perumda Air Minum Tirta Terubuk Kab. Bengkalis
Authors: Boy Asril
Published: February 2022

Pompa adalah suatu alat (mesin fluida) yang banyak digunakan dalam suatu industri khususnya di industri Perumda Air Minum Tirta Terubuk Kab Bengkalis. Pompa merupakan suatu alat yang dapat memindahkan fluida dari satu tempat ke tempat yang lain melalui suatu media perpipaan dengan cara menambahkan energi pada fluida yang dipindahkan dan berlangsung secara kontinyu. Pompa sentrifugal ini sering mengalami kerusakan kecil maupun besar khusus nya di bagian komponen. Penelitian ini menggunakan metode Reliability Centered Maintainance (RCM). Untuk melakukan analisa perawatan pompa sentrifugal yang di gunakan di Perumda Air Minum Tirta Terubuk Kab Bengkalis. Metode RCM adalah metode yang di gunakan untuk menganalisa perawatan pada komponen-komponen yang mungkin menyebabkan kerusakan pada pompa sentrifugal. Hasil dari analisa didapatkan bahwa komponen-komponen pompa yang kritis berdasarkan diagram yaitu pareto dan  fishbone yang terdapat 5 kerusakan  dengan nilai Rpn tertinggi. Satu masalah terbesar yang jadi perioritas, perioritas utama dalam menentukan masalah potensi kegagalan pada proses kerusakan komponen pompa yang dipilih berdasarkan diagram pareto. Satu masalah terbesar yang jadi perioritas adalah raber kopling rusak RPN (300) yang berpotensi menjadi kegagalan proses kerusakan komponen pompa
PENGARUH SENAM LANSIA DALAM PENINGKATAN FUNGSI KOGNITIF KELOMPOK LANSIA DI BALAI PELAYANAN PENYANTUNAN LANJUT USIA (BPPLU) BENGKULU
Authors: Pardosi Sariman , Marsinova Derison
Published: February 2022

Pembangunan nasional di segala bidang yang selama ini telah dilaksanakan oleh pemerintah, telah mampu meningkatkan derajat kesehatan masyarakat secara umum  antara lain dapat dilihat dari menurunnya  angka  kematian  ibu dan bayi serta  meningkatnya  angka  umur  harapan  hidup.  Berdsarkan Susenas tahun 2014 jumlah lansia di Indonesia mencapai 20,24 juta jiwa setara dengan 8.03% dari jumlah penduduk Indonesia. Jumlah lansia perempuan lebih banyak daripada laki-laki, 10,77 juta lansia dibandingkan dengan 9,47 juta laki-laki dan diproyeksikan pada tahun 2020 akan meningkat sebesar 11,34%  (BPS, 2014).
Pemberian latihan olahraga pada usia lanjut dimulai dengan intensitas dan waktu yang ringan kemudian meningkat secara pelahan-lahan serta tidak bersifat kompetitif/ bertanding. Latihan olahraga bagi manula mempunyai manfaat besar karena dapat meningkatkan kemampuan aerobik yaitu akan meningkatkan aliran dan  volume  pasokan  darah  yang  membawa   oksigen  ke  organ-organ  tubuh terutama ke organ otak. Hal ini didukung oleh penelitian selama 10 tahun pada pria usia lanjut berdasarkan data dari Finlandia, Italia dan Belanda oleh B.M. Van Gelder   dan   kawan-kawan   (2004)   tentang   hubungan   aktifitas   fisik   dengan penurunan    kognitif.    Penelitian    tersebut   menyimpulkan    bahwa   penurunan intensitas dan durasi aktifitas akan mempercepat proses penurunan fungsi kognitif.
Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian pre eksperiment dengan rancangan penelitian yang   digunakan one group   pre   and post test. yaitu sampel pada penelitian ini diobservasi terlebih dahulu sebelum diberi perlakuan, kondisi setelah diberikan perlakuan sampel. Analisis dilakukan dengan univariat dan analisis bivariat. Sebelum uji statistik, dilakukan terlebih dahulu dilakukan uji normalitas data dengan uji Kolmogorof Smirnov yang dikumpulkan kemudian di tentukan uji statistik yang akan dilakukan  dengan uji Wilcoxon bertujuan untuk mengetahui dampak dari perlakuan terhadap nilai MMSE setelah senam lansia dengan tingkat kepercayaan  95% atau nilai ? = 0,05.
Hasil penelitian menunjukan bahwa responden lansia menurut tingkat pendidikan sebanyak 16 orang atau  80%  dengan tingkat pendidikan SD, dan menurut umur minimal 60 tahun dan maksimal 84 tahun nilai mean MMSE untuk pre senam lansia sebesar 21,70 dan nilai mean MMSE untuk post senam lansia sebesar 25,35, terjadi peningkatan nilai mean sebesar 3,65. Nilai p value 0,001 < 0,05 dapat disimpulkan bahwa ada pengaruh senam lansia terhadap peningkatan kognitif lansia
PENGARUH PENDIDIKAN KESEHATAN MENGGUNAKAN MEDIA VIDEO TERHADAP KESIAPAN IBU HAMIL DALAM MENGHADAPI PERSALINAN
Authors: Lisnawati Lisnawati , Linggar Adi Prahastuti Dara
Published: February 2022

Problems : The indirect cause of maternal death is that there are still many late cases. Case 3 is late, including: being late in recognizing the danger signs of childbirth and making decisions, being referred too late to a health facility, being late being handled by health workers at a health service facility. Readiness in the face of childbirth is one solution to prevent maternal death. The aim of the research: to determine the effect of health education using video media on the readiness of pregnant women in facing childbirth in the working area of ??UPTD Puskesmas Talun, Cirebon Regency. Method: The research design used a quasi-experimental design with pretest and posttest with one group design. The sampling technique was carried out by non-probability sampling technique. Sampling used a total sampling technique (30 pregnant women) in the second and third trimesters. Bivariate analysis using Wilcoxon test. Results: The results of the pre test and post test showed an increase. The effect of health education using video media on mother's readiness in facing childbirth (p value = 0.000). Conclusion: There is an effect of health education using video media on the readiness of pregnant women in facing childbirth.
 
Keywords: Health Education Using Video Media, Readiness, Pregnant Women
ОСОБЛИВОСТІ НАДАННЯ ПСИХОЛОГІЧНОЇ ДОПОМОГИ ПРАЦІВНИКАМ ПОЛІЦІЇ ПІСЛЯ ЇХ ПЕРЕБУВАННЯ В ЕКСТРЕМАЛЬНИХ СИТУАЦІЯХ: ЗАКОРДОННИЙ ДОСВІД
Authors: П’янківська Л.
Published: February 2022

У статті проаналізовано зарубіжний досвід з питань надання психологічної допомоги працівникам поліції після їх перебування в екстремальних ситуаціях. Розкрито зміст поняття «психологічна допомога» й визначено основні її етичні принципи. Виокремлено базові чинники, що визначають особливості надання психологічної допомоги працівникам поліції у низці зарубіжних країн. Зосереджено увагу на досвіді надання психологічної допомоги працівникам поліції у розвинутих країнах світу. Зокрема, детально охарактеризовано Програми ACCESS EAP, CIT (США), POS (Канада), методи запобігання травм (Великобританія). Акцентовано увагу на необхідності доповнення вітчизняних доробків з досліджуваної проблематики й доцільності розроблення практичних рекомендацій щодо їх застосування у системі МВС України.
МОТИВАЦІЙНА ГОТОВНІСТЬ ЗДОБУВАЧІВ ВИЩОЇ ОСВІТИ ДО МАЙБУТНЬОЇ ПРОФЕСІЇ ПСИХОЛОГА
Authors: Столярова О. , Сафін О. , Діхтяренко С. , Рабодзей Т.
Published: February 2022

У статті розглянуто проблему визначення та обґрунтування змісту мотиваційної готовності до професійної діяльності майбутніх психологів. Зазначається, що мотиваційна готовність є необхідною умовою успішної професійної самореалізації молодого фахівця - психолога. Для підвищення рівня підготовки сучасних фахівців до успішної трудової діяльності та конкурентоспроможності на ринку праці ключовим завданням є розвиток професійної мотивації та особистісна зацікавленість в обраній спеціальності. Здійснено теоретичний аналіз поглядів науковців з цієї проблематики. Визначено, що мотиваційна готовність є однією із умов успішного виконання психологами майбутньої професійної діяльності.
Rechazo a los retornantes: nuevos escenarios de riesgo para los migrantes transnacionales en contexto de pandemia COVID-19
Authors: Canedo Sibely
Published: February 2022

El presente artículo analiza las prácticas de agresión y discriminación hacia las personas migrantes en el contexto de la pandemia por COVID-19. No solamente se trata de las políticas antiinmigrantes habituales, sino que ahora se le añade el rechazo a los migrantes transnacionales de retorno por parte de los gobiernos de los países de origen. De esta forma, se analizan estas políticas que se cristalizaron sobre todo con el cierre arbitrario de fronteras, dejando varados y en la incertidumbre a miles de migrantes latinoamericanos. A través de un enfoque cualitativo y analítico, se realizó una revisión documental de informes de organizaciones para la defensa de los derechos humanos, así como de la prensa internacional, en el periodo de marzo a julio de 2020, uno de los más críticos para la población migrante en la región. En especial para venezolanos, bolivianos y centroamericanos que intentaban regresar a sus países, luego del cierre de empresas provocado por el coronavirus en los lugares a los que habían migrado. Se encontró que la acción y negligencia de los Estados provocó la múltiple violación de los derechos humanos de estas personas, quienes vieron en peligro su integridad y su vida, sin un fundamento legal y ético.
La Foto Del Mese
Authors: N. Di Paolo , L. Capotondo , G. Garosi
Published: February 2022

Abstract non disponibile
Attività di Dialisi-Vacanze in un Centro Ospedaliero del Sud Italia: Il Centro Dialisi di Maratea
Authors: Di Iorio B. , Gaudiano G. , Altieri C. , Terracciano V.
Published: February 2022

Abstract non disponibile
Il Platelet Activating Factor (PAF), Marcatore Di Biocompatibilità, Nella Dialisi Con Membrane in Poliacrilonitrile
Authors: Guastoni C. , Tetra C. , Hoenich N.A. , Gervasio R. , Sereni L. , Tessore E. , Wratten M.L. , Civati G.
Published: February 2022

Abstract non disponibile
A Case of Fatal Maternal-Fetal Conflict: HELLP Syndrome Diagnosed in a Second Trimester Pregnancy
Authors: DO Nia Pellone , Nahidi Seyed Mohammad , Dave Salonie , Borden Sean , Faustin Daniel
Published: February 2022

HELLP syndrome is part of the preeclampsia-eclampsia spectrum, and it typically presents after 20 weeks of gestation. In this case report, we review the hypotheses for the pathophysiology of HELLP and report one of the few cases of the syndrome presenting prior to 20 weeks of gestation.
Triplet Pregnancy with a Complete Hydatidiform Mole and Two Live Fetuses: A Case Report
Authors: Gobetti Pancieri Bárbara , Nassur Ozório Carla , Viana Bueno Gomes Carolina , Paula Alves Ribeiro Ana , Fiorin Vasconcellos Vitor , Bermudes Musiello Rubens , Antönio Chambô Filho
Published: February 2022

Background: A complete hydatidiform mole (CHM) coexistent with a live fetus is rare; however, in a triplet pregnancy it is even rarer. In such cases, diagnosis is complex and often delayed, since unlike cases of a hydatidiform mole alone, the coexisting CHM often fails to be detected at ultrasound, while Β-hCG, a marker of the disease, is already elevated because of the multiple pregnancy. The risk of maternal complications and of progression to malignant gestational trophoblastic disease is significantly greater in cases of a complete mole. Case: The case reported here refers to a triplet pregnancy consisting of two viable fetuses and a CHM. Conclusion: Outcome was favorable for the two live fetuses; however, the hydatidiform mole progressed to an invasive mole, requiring chemotherapy. Remission was achieved successfully.
Comparison of New COPD Diagnostic Methods to Traditional Spirometry Method
Authors: Klir John , Uchechukwu Nwordu David
Published: February 2022

Chronic obstructive pulmonary disease (COPD) is one of major non-communicable diseases affecting millions of people around the world. It is slowly developing and progressing disease characterized by mostly irreversible pathophysiological changes resulting in gradual loss of pulmonary function. It presents with different phenotypes associated with specific pathophysiological changes in individual patients. Diagnostic evaluation of COPD traditionally includes pulmonary function tests (PFT) using spirometry. Spirometry is considered to be the internationally accepted gold standard diagnostic method during evaluation for COPD. Although spirometry is commonly used to diagnose COPD, it may sometime lack adequate sensitivity to detect fine pathophysiological changes associated with particular phenotypes of COPD. Development and use of new alternate diagnostic methods could improve not only diagnosis of COPD, but also optimize the management and treatments.
High prevalence of Paramarteilia canceri infecting velvet swimming crabs Necora puber in Ireland
Authors: Collins E , Ward GM , Bateman KS , Cheslett DL , Hooper C , Feist SW , Ironside JE , Morrissey T , O’Toole C , Tully O , Ross SH , Stentiford GD , Swords F , Urrutia A , Bass D
Published: February 2022

The velvet swimming crab Necora puber has been fished in Ireland since the early 1980s and contributes significant income to smaller fishing vessels. From 2016 onwards, reduced landings have been reported. We undertook a full pathological investigation of crabs from fishing grounds at 3 sites on the west (Galway), southwest (Castletownbere) and east (Howth) coasts of Ireland. Histopathology, transmission electron microscopy and molecular taxonomic and phylogenetic analyses showed high prevalence and infection level of Paramarteilia canceri, previously only reported from the edible crab Cancer pagurus. This study provides the first molecular data for P. canceri, and shows its phylogenetic position in the order Paramyxida (Rhizaria). Other parasites and symbionts detected in the crabs were also noted, including widespread but low co-infection with Hematodinium sp. and a microsporidian consistent with the Ameson and Nadelspora genera. This is the first histological record of Hematodinium sp. in velvet crabs from Ireland. Four N. puber individuals across 2 sites were co-infected by P. canceri and Hematodinium sp. At one site, 3 velvet crabs infected with P. canceri were co-infected with the first microsporidian recorded from this host; the microsporidian 18S sequence was almost identical to Ameson pulvis, known to infect European shore crabs Carcinus maenas. The study provides a comprehensive phylogenetic analysis of this and all other available Ameson and Nadelspora 18S sequences. Together, these findings provide a baseline for further investigations of N. puber populations along the coast of Ireland.
Epibiont community composition of red mangroves Rhizophora mangle are contingent on root characteristics
Authors: Stewart HA , Janiak DS , Wright JL , Hunt DAGA , Carmona Cortes A , Powell KT , Chapman LJ , Altieri AH
Published: February 2022

Foundation species traits that structure communities are rarely experimentally examined; thus, a predictive understanding of their functions lags behind patterns of observed species associations. Red mangrove Rhizophora mangle roots form complex living habitats that support diverse epibiont communities, making them a model system for testing links between variation in foundation species traits and associated biodiversity. Here, we compared epibiont community composition between living and non-living mangrove roots, as well as root mimics, to test how foundation species traits affect community structure. We also quantified the community structure of associated mobile invertebrates to examine their relationship with secondary foundation species (e.g. sponges, bivalves) that grow on the roots. After 14 mo of colonization and succession, substrate composition (i.e. mangrove, wood, PVC) had significant effects on community composition, richness, and abundance of sessile epibionts and mobile invertebrates. Non-living mangrove roots were 5 times more likely to deteriorate, and consequently had the lowest epibiont richness and abundance. We found strong positive relationships between mobile invertebrate richness and the abundance, measured as biomass, and richness of sponges and bivalves, suggesting that variation among roots in secondary foundation species play an important role in mediating mobile invertebrate community composition. This study highlights the functional role of habitat structure and how rapidly that function can be lost without biogenic maintenance. Our results indicate the importance of facilitation cascades in fostering diverse mobile invertebrate communities and highlight both advantages and limitations in using artificial structures in restoration programs.
The dynamics of gene expression in human lung microvascular endothelial cells after stimulation with inflammatory cytokines
Authors: Zachlederová M , Jarolím P
Published: February 2022

Vascular endothelium plays an essential role in the pathogenesis of vasoocclusion. The changes in the endothelial cell function can be triggered by changes in gene expression caused by interaction with cytokines and blood cells. Using cDNA arrays, we have recently reported complex patterns of gene expression after stimulation of endothelial cells with TNFalpha and IL-1beta. Better understanding of the time course of gene expression changes, their concentration dependence and reversibility after withdrawal of the offending cytokine is essential for successful prevention and therapy of vasoocclusion. Here we present a detailed study of the concentration dependence and time course of gene expression in endothelial cells after their exposure to TNFalpha and IL-1beta. We focus on the adhesion molecules (VCAM-1, ICAM-1, E-selectin) and cytokines (IL-6, GCP-2, MCP-1) that are likely to contribute to vasoocclusion. We report differences in the time course and intensity of their expression and in their response to TNFalpha and IL-1beta stimulation. We demonstrate that expression of the studied genes is upregulated by low TNFalpha concentrations that better reflect the TNFalpha levels detected in the plasma of patients developing vasoocclusion. These results help to understand the changes in the endothelium and to design rational prevention and therapy of vasoocclusion.
Operant behavior of the rat can be controlled by the configuration of objects in an animated scene displayed on a computer screen
Authors: Nekovářová T , Klement D
Published: February 2022

We developed a novel behavioral task in which rats learn to recognize the configuration of objects in an animated scene displayed on a computer screen. The scene consisted of a moving bar and a stationary rectangle. Rats deprived of food were trained to press a lever for reward in a small chamber located in front of the screen. Lever presses were rewarded only when the bar was at the rectangle. Rats anticipated the reward by gradually increasing frequency of lever pressing as the bar approached the rectangle. Control experiments showed that neither the timing nor the discrimination of rewarded and non-rewarded periods as two discrete conditions explain behavior of the rat. Because the changes in the scene were generated by movement of the object, the presented task could be used for studying neural structures involved in spatial behavior of rats using virtual reality technology.
Risperidone potentiates the sympathetic and hyperthermic reactions induced by orexin A in the rat
Authors: Monda M , Viggiano An , Viggiano Al , Viggiano E , De Luca V
Published: February 2022

This experiment tested the effect of risperidone on the sympathetic and thermogenic effects induced by orexin A. The firing rates of sympathetic nerves to interscapular brown adipose tissue (IBAT), along with IBAT and colon temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle and over a period of 2 hours after the injection. The same variables were monitored in rats with an intraperitoneal administration of risperidone (50 mg/kg bw), injected 30 min before the orexin administration. The results show that orexin A increases the sympathetic firing rate, IBAT, colonic temperatures and heart rate. This increase is enhanced by the injection of risperidone. These findings suggest that risperidone elevates the responses due to orexin, probably through an involvement of serotoninergic and dopaminergic pathways, which are affected by risperidone. Furthermore, we suggested the name "hyperthermine A" as additional denomination of "orexin A" by considering the strong influence of this neuropeptide on body temperature.
Coincidence Anticipation Timing Responses with Head Tracking and Eye Tracking
Authors: Ross Erin , Kinney Micah , Fogt Nick
Published: February 2022

BACKGROUND: Head tracking movements are common in interceptive tasks. The benefits of these movements are unclear. The purpose of this study was to compare coincidence anticipation timing (CAT) responses for a simulated approaching object when the eyes were used in tracking the
object and when the head was used in tracking the object.METHODS: A total of 29 subjects participated. A Bassin Anticipation Timer consisting of a track of sequentially illuminated lights was used to simulate an approaching object at velocities of 223 cm · s−1
to 894 cm · s−1. Each velocity was used 10 times under 2 conditions. In one condition, subjects were told to turn the eyes with the stimulus. In the other condition, subjects viewed the stimulus through apertures and were told to turn the head with the stimulus. Subjects
pushed a button to coincide with illumination of the final light on the track.RESULTS: Signed CAT errors, unsigned CAT errors, and variable CAT errors were compared between the head movement (HM) and eye movement (EM) conditions. No significant differences were noted for the signed
errors (mean signed error at 894 cm · s−1; 10.3 ± 75.4 ms (HM), −16.1 ± 51.0 ms (EM). However, the unsigned and variable errors were significantly larger at some stimulus velocities in the head movement condition [mean unsigned error at 894 cm ·
s−1: 82.6.0 ± 45.9 ms (HM), 59.0 ± 22.4 ms (EM); mean variable error at 894 cm · s−1; 78.0 ± 37.8 ms (HM), 49.2 ± 17.1ms (EM)].DISCUSSION: Head movement did not result in improved CAT performance compared to eye
movements. Further work will be required to determine whether these results are generalizable to situations where head tracking is required but apertures are not worn.Ross E, Kinney M, Fogt N. Coincidence anticipation timing responses with head tracking and eye tracking. Aerosp
Med Hum Perform. 2022; 93(2):79–88.
Surveying the Genomic Landscape Supporting the Development of Precision Military Aerospace Medicine
Authors: Chapleau Richard R. , Regn Dara D. , de Castro Mauricio J.
Published: February 2022

INTRODUCTION: Precision medicine is an approach to healthcare that is modifying clinical management by leveraging technological advances in genomics that assess a patient’s genetic information to identify unique predispositions. While the civilian sector is integrating
genomics widely to personalize diagnosis and treatment, the military medical environment has reacted more slowly. The operational requirements of military service encourage a tailored approach for focusing military precision medicine on occupation-specific conditions. Here, we present a survey
of the genomic landscape related to military aerospace medicine.METHODS: We collated observations from genome-wide association studies (GWAS) relating genetic markers to conditions that may negatively influence flight operations and for which the U.S. Air Force School of Aerospace
Medicine’s Aeromedical Consult Service (ACS) provides aeromedical waiver guidance. Our sources for identifying relevant literature were the GWAS Catalog, the Atlas of GWAS Summary Statistics, and PubMed/Google Scholar searches.RESULTS: Using the ACS guidance as a starting
point, we found 1572 papers describing 84 clinical conditions with genetic associations. The earliest aeromedical GWAS publication was in 2006, increasing to 225 publications in 2019. We identified 42,020 polymorphisms from more than 84 million participants across the studies.CONCLUSION:
Our study revealed areas where deeper investigations into how genetic markers manifest in clinical diagnosis, prevention, or risk management could lead to increased medical readiness. Additionally, our results show those clinical areas for which guidance could include genetic risk considerations.Chapleau
RR, Regn DD, de Castro MJ. Surveying the genomic landscape supporting the development of precision military aerospace medicine. Aerosp Med Hum Perform. 2022; 93(2):89–93.
Impact of Time Delay on Simulated Operative Video Telementoring: A Pilot Study
Authors: Kamine Tovy Haber , Smith Brandon W. , Fernandez Gladys L.
Published: February 2022

INTRODUCTION: As NASA and private spaceflight companies push forward with plans for missions to cis-lunar and interplanetary space, the risk of surgical emergency increases. At latencies above 500 ms, telesurgery is not likely to be successful, so near-real-time telementoring
is a more viable option. We examined the effect of a 700-ms time delay on the performance of first year surgical residents on a simulated task requiring significant feedback from a mentor in a pilot study.METHODS: A simulated surgical task requiring precision and accuracy with built-in
error detection was used. Each resident underwent two trials, one with a mentor in the same room and one with the mentor using a teleconference with time delay. Outcomes measured included time to complete task, game pieces successfully removed, number of errors, and scores on the NASA Task
Load Index by both mentor and operator. Data were analyzed using paired t-tests.RESULTS: The time delay group removed significantly fewer pieces successfully than the real time group (3.0 vs. 1.6, P = 0.02). There was no difference in the NASA Task Load Index (TLX)
scores for the operators between the two groups, but the mentor reported significantly higher scores on Mental Demand (5.6 vs. 12.0, P = 0.04) and Effort (6.2 vs. 11.8, P = 0.05) during the time-delayed trials.DISCUSSION: A 750-ms time delay significantly degraded
performance on the task. Though operator TLX scores were not affected, mentor TLX scores indicated significantly increased mental load. Telementoring is viable, but more onerous than in-person mentoring.Kamine TH, Smith BW, Fernandez GL. Impact of time delay on simulated operative
video telementoring: a pilot study. Aerosp Med Hum Perform. 2022; 93(2):123–127.
Outcome of laparoscopic ovarian drilling (LOD) for women with polycystic ovary syndrome (PCOS): A retrospective case note review
Authors: Syed Rifat , Zaidi Jamal , Dhar Nabeha
Published: February 2022

Objective: To evaluate the effectivity of laparoscopic ovarian drilling procedures at the East Sussex Healthcare Trust, UK, over the past decade on sub-fertile women with polycystic ovary syndrome, regardless of clomiphene resistance. Design: Retrospective case note review of LOD procedures Methods: Study 1: Evaluating a systematic literature review investigating ovulation and pregnancy rates following LOD. Study 2: An audit of 58 women with LOD treated for ovulation induction at the ESHT fertility clinic between 2005-2014. Main outcome measures: Ovulation, pregnancy, live birth, miscarriage rates; tubal patency; associated pathologies; previous treatments compared with Cochrane Review 2012. Results: Study 1: From the literature review, 71% achieved ovulation, whereas the pregnancy, live birth and miscarriage rates were 25-51%, 24-44% and 4-9% respectively. Study 2: Of the 58 patients studied, ovulation rate was 69%, pregnancy rate was 39.4% and live birth rate was 30.3%. The miscarriage rate was 15.4%. Pregnancy outcome after LOD, irrespective of further treatment, showed 34 pregnancies. Including 17 spontaneous pregnancies and 17 pregnancies after further treatment. Of the 34 pregnancies, 85.3% were live birth, 11.7% miscarriages and 1 ectopic pregnancy. Conclusion: No significant difference in ovulation rates post-LOD in ESHT, which is comparable to published studies. The low pregnancy and live birth rates indicate that additional factors affect the success of LOD. Co-existing pathology is associated with lower pregnancy rate post-LOD. Novel theories are postulated to explain underlying pathologies, thus PCOS treatment may change and open a fascinating area of research.
Response of white clover cultivars to sheep and beef cattle grazing management across three pastoral environments in New Zealand.
Authors: Jahufer Zulfi , HESLOP Angus , COUSINS Greig , Woodfield Derek , Ford John
Published: February 2022

White clover (Trifolium repens L.) is the main legume component in temperate perennial pasture swards in New Zealand. Developing broadly adapted cultivars is an important objective in white clover breeding programs. Field trials across years, seasons, locations and grazing environments, help breeders select superior material, and assess the merit of new cultivars available to farmers. This paper is based on results from analysis of data from field trials across three locations in New Zealand: Kerikeri (cattle grazed), Palmerston North (cattle grazed) and Lincoln (sheep grazed), evaluating 44 experimental varieties and 16 cultivars for seasonal growth and leaf size. We report on performance of the 16 cultivars across the three locations.

Significant genotype-by-environment interactions were estimated for seasonal growth and leaf size.  The importance of conducting multi-location and year evaluation trials under cattle and sheep grazing management methods (rotational/set stocking) was demonstrated. Among the 16 cultivars, Legacy showed above average performance across all 3 locations.  Hilltop when compared among similar leaf size material, showed above average seasonal growth across years under rotational sheep grazing management during the first 4 years of the trial at Lincoln. Hilltop also showed above average seasonal growth under set socking with sheep in years 5 and 6 at Lincoln.
A summary of research results on pasture responses to fertiliser and lime in the South Island hill and high country
Authors: Morton Jeff
Published: February 2022

The published results from trials used to determine nutrient and lime requirements of legume-based pastures in South Island hill and high country are summarised. Most of the research in the 1950’s and 1960’s found that sulphur (S) alone was required on the less weathered and leached Semi-arid and Pallic soils but both S and phosphorus (P) were required on the more weathered and leached Brown soils. The severe lack of S necessitated the application of rapidly plant-available S as gypsum. Research in the 1970’s and 1980’s determined the most effective particle size ranges in relation to frequency of application of elemental S to provide adequate S. This work highlighted a need for sufficient S for legume growth before a growth response to P was measured on most soils which has resulted in the manufacture of a range of suitable sulphur fortified superphosphate products. During this 40-year period a limited amount of work showed that nitrogen (N) fertiliser could enhance the growth of resident grasses and legumes and that added S could improve the response. Molybdenum (Mo) has been the only trace element that has been lacking for pasture growth and research has been reported that defines optimal rates, frequency of application and criteria for interpretation. In the last 20 years, the need lime to alleviate soil aluminium (Al) toxicity on these mainly acidic soils has been demonstrated to allow legumes to establish and persist. 

Current gaps in available information indicate potential areas for more research. These gaps include identifying responses to rates of P and S on pasture with varying legume content on different hill slopes, differential application of elemental sulphur and lime on shady aspects of Semi-Arid and Pallic soils, definition of P and S requirements of pure legume swards, the role of fertiliser N to improve legume establishment, fertiliser and management options to break down thatch at the soil surface and improve legume establishment, determination of the soil and landscape factors that affect the spatial variability of soil Al concentrations, further confirmation of the role of lime injection into soil layers with high soil Al toxicity,  the assessment of test strips of applied Mo to assist in the identification of deficiencies in legumes and the combination of information into a decision support system to aid farmers in their selection of legume species and fertiliser and lime requirements for different areas of their farms.