bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembangunan Kerohanian Usahawan Melayu di Malaysia : Tinjauan dari Perspektif Guru-Guru Murshid
Authors: Abdul Kadir Abu Yazid , Mohammed Zabidi Ahmad Fakhrurrazi , Yaacob Salmy Edawati
Published: November 2022

Spirituality is the most important aspect in a person of Malay entrepreneurs. The spiritual system of an entrepreneur which consists of heart, passion, intellect and spirit needs to be developed through the method of guidance of a murshid teacher. Failure Malay entrepreneurs to develop a system of spirituality is caused by a lack of spiritual practices such as mysticism, suhbah, manners, remembrance, fasting, prayer, charity and muraqabah. This study will examine these factors in depth, especially for entrepreneurs with secular and non -secular entrepreneurs. Thus, this study aims to explore the spiritual practices from the point of view of murshid teachers who bring success in the field of entrepreneurship in Malaysia. This study is qualitative in nature by taking a content analysis approach and in -depth interview method. The results of the study found that spiritual practices influence the personal nature of entrepreneurs, build self -confidence, build self -defense systems, and form noble morals. In addition, spiritual practice also helps to aspects of self -management and business that are more beneficial to lead to success in this world and in the hereafter.

ABSTRAK

Kerohanian merupakan aspek paling penting dalam diri seseorang usahawan Melayu. Sistem kerohanian seorang usahawan yang terdiri daripada hati, nafsu, akal dan roh perlu di bangunkan melalui kaedah bimbingan seorang guru murshid. Kegagalan usahawan Melayu untuk membangunkan sistem kerohanian adalah disebabkan oleh faktor kekurangan amalan kerohanian seperti suluk, suhbah, adab, zikir, puasa, solat, zakat dan muraqabah. Kajian ini akan meneliti faktor tersebut secara mendalam khususnya terhadap usahawan bertarekat dengan usahawan tidak bertarekat. Justeru, kajian ini bertujuan untuk meneroka amalan-amalan kerohanian dari sudut pandang guru-guru murshid yang membawa kejayaan dalam bidang keusahawanan  di Malaysia. Kajian ini berbentuk kualitatif dengan mengambil pendekatan analisis kandungan dan kaedah temubual mendalam. Hasil kajian mendapati amalan kerohanian mempengaruhi sifat peribadi usahawan, membina keyakinan diri, membina sistem pertahanan diri, dan membentuk akhlak  mulia. Di samping itu, amalan kerohanian  turut membantu kepada aspek pengurusan diri dan perniagaan yang lebih bermanfaat sehingga membawa kepada kejayaan di dunia dan di akhirat kelak.
Penerimaan Fatwa Dalam Kalangan Masyarakat Muslim Malaysia: Kajian Empirikal
Authors: Rosidi Mohd Harifadilah , Mokhtar Ahmad Wifaq , Abdul Majid Mohd Nasir
Published: November 2022

Fatwa telah melalui proses evolusi daripada jawapan persoalan agama kepada undang-undang syariah bagi negara yang mewartakan fatwa tersebut seperti Malaysia. Sehingga tahun 2022, terdapat sebanyak 1404 fatwa yang telah diputuskan di peringkat kebangsaan dan negeri manakala 398 fatwa telah diwartakan di negeri-negeri di Malaysia. Kajian dan penulisan lepas menunjukkan penolakan terhadap keputusan fatwa serta tahap penerimaan fatwa yang rendah dalam kalangan responden di beberapa buah negeri. Jesteru itu, kajian ini bertujuan mengenal pasti tahap penerimaan fatwa yang terkini dalam kalangan masyarakat Muslim seluruh negeri di Malaysia. Kaedah penyelidikan yang digunakan ialah kaedah kuantitatif dengan menerima pakai instrumen soal selidik dalam talian untuk mendapatkan data. Data kajian diperolehi daripada 500 peserta melalui teknik persampelan kluster berbilang peringkat dan kemudiannya dianalisis melalui jadual frekuensi dan statistik min. Hasil kajian mendapati tahap penerimaan fatwa dalam kalangan masyarakat Muslim Malaysia adalah tinggi dengan pencapaian skor min sebanyak 4.60.  Selain itu, kajian ini juga mencapai skor min yang tinggi terhadap tahap pengetahuan fatwa (M = 4.50) dan penggunaan media dalam talian untuk mendapatkan maklumat fatwa (M = 4.08) dalam kalangan masyarakat Muslim Malaysia. Walaubagaimanapun, kajian ini mendapati kesedaran fatwa masyarakat Muslim Malaysia berada pada tahap yang sederhana dengan skor min sebanyak 3.60. Seterusnya, kajian ini mencadangkan usaha untuk meningkatkan kesedaran masyarakat terhadap kepentingan fatwa perlu dipergiatkan lagi mengunakan platform media dalam talian oleh institusi fatwa di Malaysia supaya masyarakat sentiasa cakna terhadap fatwa-fatwa semasa.
Kekeliruan Antara Jenayah Zina Dan Rogol Statutori Di Malaysia: Keperluan Kepada Penjelasan Fatwa
Authors: Abdulah Nur Aina
Published: November 2022

Zina adalah jenayah berat di dalam Islam, begitu juga dengan rogol.  Kedua-duanya adalah persetubuhan haram di luar perkahwinan, tetapi dibezakan oleh cara ia dilakukan. Permasalahnya adalah kekeliruan yang terjadi berikutan undang-undang rogol statutori di Malaysia yang mendefinisikan rogol sebagai persetubuhan yang dilakukan oleh seorang lelaki bersama seorang perempuan yang berumur di bawah 16 tahun sama ada dengan kerelaannya atau tidak. Oleh itu, kajian ini bertujuan menganalisa isu-isu yang menjadi kekeliruan antara jenayah zina dan rogol statutori ini. Selain itu, objektif kajian ini adalah untuk memberi cadangan kepada pihak berautoriti agama untuk memberi penjelasan hukum melalui fatwa dalam isu ini. Metodologi kajian kualitatif digunakan dengan reka bentuk analisis kandungan. Hasil kajian mendapati terdapat tiga perkara yang menjadi kekeliruan; iaitu elemen kerelaan, umur perempuan dan hukuman yang dikenakan.
Analisis Literatur Sistematik Terhadap Peranan Penggunaan Logo Zakat Dalam Meningkatkan Kutipan Zakat Korporat Di Malaysia
Authors: Sukari Afaf
Published: November 2022

Kutipan zakat korporat tahunan menduduki tempat kedua tertinggi selepas zakat pendapatan.  Ini menunjukkan terdapat ruang bagi membolehkan jumlah kutipan zakat korporat dioptimumkan melalui inisiatif yang berkesan. Bagi meningkatkan kadar kutipan zakat korporat, pihak Lembaga Zakat Negeri Kedah (LZNK) dan Majlis Agama Islam Wilayah Persekutuan (MAIWP) kini telah memperkenalkan penggunaan logo zakat terhadap syarikat-syarikat korporat yang membayar zakat korporat. Dengan itu, kajian ini dilakukan adalah untuk menganalisis berkenaan peranan penggunaan logo zakat dalam meningkatkan kutipan zakat korporat di Malaysia dengan menggunakan analisis literatur sistematik. Kajian ini menggunakan kaedah PRISMA iaitu dengan membuat carian artikel di pangkalan data Scopus dan My Jurnal secara sistematik sepanjang tempoh bermula 2021 hingga 2022. Data yang dikumpul telah dianalisis dan direkodkan dalam carta alir PRISMA. Sejumlah 52 artikel jurnal yang terpilih berkaitan dengan topik telah dibincangkan oleh pengkaji. Hasil kajian mendapati kesedaran pembayaran zakat korporat berlaku peningkatan melalui pengenalan penggunaan logo zakat seperti yang diperkenalkan oleh pihak LZNK dan MAIWP. Diharapkan penyelidikan ini dapat memberi gambaran dan perbincangan yang berguna serta menjadi rujukan kepada penyelidik dan ahli akademik yang lain berkenaan analisis sistematik terhadap penggunaan logo zakat dalam meningkatkan kadar kutipan zakat korporat dengan menggunakan metodologi PRISMA.
Istihalah And Istihlak: Analysis On The Manufacture Processes Of Porcine Base Medicine (Low Molecular Weight Heparin (LMWH)
Authors: Azlinda Zizi , Mohd Subri Irwan , Zainal Nur Zaireena
Published: November 2022

Istihalah and istihlak are not an extraterrestrial subject and have been debated over centuries among shariah scholars. Halal Pharmaceutical had been clearly explained that must comply with shariah prerequisite to be endorsed as halal compliance medicine. However, this industry often faces unmatched medicine which able to heal deteriorated diseases such as thrombosis or embolism that require second opinion by Shariah scholars. The medicine named Low Molecular Weight Heparin (LMWH) had been imposed the fatwa on it by Malaysian National Fatwa Council (MNFC), however, some exempted conditions require this porcine base medicine for prophylaxis or therapy. This paper aims to propose istihalah and istihlak to be legal indicators through fiqh methods in the making of fatwa regarding to this notorious medicine. This paper employs qualitative methodology which using documents review method to analysis the data.
Interneten alig láthatók az MTA listás folyóiratcikkek a bölcsész- és társadalomtudomány területén
Authors: Péter Sasvári
Published: November 2022

A bölcsész- és társadalomtudománnyal foglalkozó MTA-s tudományos bizottságok nemzetközi és hazai listás lapjaiba közel 28 ezer folyóiratcikket írtak 2021-ben a magyar kutatók az MTMT szerint. A publikációk 46%-a bír DOI azonosítóval, 18%-a jelent meg Scimagojr folyóiratban és 10%-a rendelkezik WoS azonosítóval. A DOI azonosítóval ellátott cikkek kétszer, a Scimagojr közlemények négyszer és a WoS publikációk ötször több hivatkozással bírnak az összes cikkhez viszonyítva a vizsgált adatok alapján. Mivel alacsony a WoS és a Scopus indexáltságú cikkek aránya, így a bölcsész- és társadalomtudósok sok közleménye nem számít az alapítványi és egyházi fenntartású egyetemek finanszírozási indikátorainak a teljesítéséhez. Ennek a kedvezőtlen helyzetnek a változtatásához az MTA listás folyóiratok esetén jó lenne bevezetni a DOI azonosítót, majd a többi WoS-os és Scopus-os kritériumot.
Meningkatkan Kemampuan Motorik Halus melalui Kegiatan Finger Painting Menggunakan Pasta Ajaib Pelangi
Authors: Arum Sekar Sari Wuni , Aprilina Nisa Fitri Novida
Published: November 2022

Penelitian ini mempunyai tujuan untuk meningkatkan kemampuan motorik halus anak melalui kegiatan finger painting menggunakan pasta ajaib pelangi di kelompok B Taman Kanak-kanak Dharma Wanita 1 Babadan Ngancar Kabupaten Kediri Tahun Pelajaran 2021/2022. Kegiatan finger painting menggunakan pasta ajaib pelangi ini dapat menarik minat anak guna meningkatkan kemampuan motorik halus anak. Upaya meningkatkan kemampuan motorik halus pada kegiatan finger painting ini menekankan pada penyelarasan antara mata dengan otot tangan anak serta kelenturan jari jemari anak. Sebagai subjek dalam penelitian ini yaitu anak kelompok B TK Dharma Wanita 1 Babadan dengan jumlah 15 anak, terdiri dari 5 anak laki-laki dan 10 anak perempuan. Peneliti telah mengadakan perbaikan pembeljaran yang dilaksanakan selama 5  hari pada siklus I dan dilanjutkan dengan 5 hari pada siklus II mengingat kemampuan motorik halus anak belum mencapai tingkat ketuntasan yang ditargetkan. Bersumber pada analisis data maka kami simpulkan bahwa aktivitas finger painting dengan menggunakan pasta ajaib pelangi bisa tingkatkan kemampuan motorik halus  pada anak kelompok B TK Dharma Wanita I Babadan Kecamatan Ngancar Kabupaten Kediri Tahun Pelajaran 2021/ 2022.

 

Abstract

This study aims to improve children's fine motor skills through finger painting activities using rainbow magic paste in group B of Dharma Wanita Kindergarten 1 Babadan Ngancar, Kediri Regency, Academic Year 2021/2022. Finger painting activities using rainbow magic paste can attract children's interest in order to improve children's fine motor skills. Efforts to improve fine motor skills in this finger painting activity emphasize the coordination of hand muscles and the flexibility of children's fingers. As subjects in this study, group B of Dharma Wanita 1 Babadan Kindergarten consisted of 15 children, consisting of 5 boys and 10 girls. Researchers have carried out learning improvements which are carried out for 5 days in cycle I and continued with 5 days in cycle II considering that children's fine motor abilities have not reached the targeted level of completeness. Based on data analysis, we conclude that finger painting activities using rainbow magic paste can improve fine motor skills in group B children of Dharma Wanita I Babadan Kindergarten, Ngancar District, Kediri Regency, Academic Year 2021/2022.
Comparing Female and Male Pedestrians’ Relative Vulnerability Based on Crash Locations
Authors: Abdous Hassan , Mahmoudabadi Abbas
Published: November 2022

While pedestrian fatalities represent 23% of all road crash fatalities in Iran, fatalities seem more common amongst female pedestrians than male pedestrians. This study investigated female pedestrian fatalities and contributing factors such as age, education, and visibility. Using Iran’s 2014 death registry data, a relative vulnerability ratio was estimated for different groups stratified by crash locations. Factors that increase the risk of fatal injuries for female pedestrians included: being under 15 years old or 41-64 years old; lacking formal education; being single; not receiving trauma care in time due to resting at home or long transfer time to a hospital; not wearing contrasting clothing in urban areas; and being involved in a crash on rural roads or at dusk/dawn on intercity roads.
Community Engagement for Road Safety in Western Australia
Authors: Williams Teresa
Published: November 2022

As a result of a review of the Western Australian Road Safety Commission’s (Commission) public participation and engagement activities carried out during 2019, broad interest in the Commission’s community engagement, attitude and behaviour research was generated. The scope of this paper is to report and discuss the data collected on community engagement with an aim of zero road trauma and fostering road user cohesion. Qualitative research methods, focus groups and kitchen table discussions were used to identify what core narratives would be effective to generate confidence and motivation in a vision of eliminating road trauma by influencing how road safety is discussed amongst community members. The study identified that Western Australia needs to adjust the narrative used to engage the community with the objective of eliminating road trauma.
Streets for Tomorrow… Today
Authors: Blewden Michael , MacArthur-Beadle Sienna , Haines Geoffrey , Raja Ali , Nord Anna , Hawley Greer
Published: November 2022

The Innovating Streets for People programme supported street space reallocation to enhance the safety, accessibility, and liveability of streets throughout Aotearoa New Zealand. The programme supported the use of tactical urbanism and co-design practices to more easily and quickly deliver temporary solutions that demonstrate and build support for change, bring forward benefits, and enhance permanent solutions. Innovating Streets for People funding (2020-21) supported the delivery of 62 temporary walking and cycling projects across Aotearoa. Approximately 89km of interim street treatments were delivered, including cycleways, safe crossings, parklets, and traffic calming. A mixed-method evaluation showed that Innovating Streets for People projects can accelerate a range of benefits, including safety and accessibility improvements and more supportive environments for active travel. A focus on continuous improvement, sector capability, and addressing system constraints, is needed to realise further programme potential. How evaluation and practice-based learning from Innovating Streets for People has been integrated within the design of the 2021-24 Streets for People Programme, and how responses are expected to support intended outcomes, are discussed.
PEMBERDAYAAN KELOMPOK NELAYAN MELALUI PROGRAM SENTRA KELAUTAN DAN PERIKANAN TERPADU DI DESA DALUM KECAMATAN SALIBABU KABUPATEN KEPULAUAN TALAUD
Authors: Prihatini Juliati , Elungan Preisy Celin , Rifai M.
Published: November 2022

Dalum Village is one of the villages in the Talaud Islands Regency with its residents mostly living as fishermen, however, fishermen in Dalum Village are fishermen who are not fully empowered or have not been developed even though the government through the Fisheries Service of the Talaud Islands Regency has empowered fishermen groups in Dalum Village through the Integrated Marine and Fisheries Center Program.  This study aims to describe and analyze the empowerment of fishermen groups through the Integrated Marine and Fisheries Center Program, inhibiting factors and supporting factors for the implementation of empowerment and efforts made in overcoming inhibiting factors. The design of this study is descriptive qualitative with an inductive approach. Data collection techniques are carried out through interviews, observations and documentation. Data analysis techniques are carried out by data reduction, data presentation and drawing conclusions. The results showed that the Empowerment of Fishermen Groups through the Integrated Marine and Fisheries Center Program in Dalum Village, Salibabu District, Talaud Islands Regency, Fishermen Group Study at the Teluk Lawasan Indah Cooperative conducted by the Fisheries Service of the Talaud Islands Regency was carried out with four indicators, namely human development, business development, environmental development and institutional development. Through these four indicators, the empowerment process has been running, but there are still many shortcomings that are obstacles in the implementation of empowerment such as: the low level of education of fishermen groups related to the technology used, the facilities and infrastructure used by fishermen groups are still simple, the dependence of fishermen groups on assistance provided by the government, and the lack of sufficient availability of electricity in the Island Regency area  Talaud.

Keywords: Fishing Group, Empowerment, Integrated Marine and Fisheries Center Program
THE EFFECT OF ANTENATAL EDUCATION ON READINESS, FEAR, PAIN, DURATION AND SATISFACTION OF LABOR IN NULLIPAR WOMEN
Authors: ÇAMLIBEL Merve , METE Samiye
Published: November 2022

This study aimed to examine the effects of antenatal education, on readiness, pain, fear, duration and satisfaction levels of nullipar women for delivery. A semi-experimental and prospective design was used. The study was made between December 2014 and March 2016. The data were collected in the 24-32nd (beginning of training), 28-36th (end of 4 weeks training) gestational weeks and 48-72 hours after deliveries. The study sample consisted of 30 participants for the study and 30 participants for the control group, 60 participants in total. The 4-week education program was applied to the study group. Data were collected using an introductory information, the birth process evaluation form, visual analogue scale, Lederman’s prenatal and postpartum self-evaluation scale. In the study group the total delivery durations and the hospitalization durations were lower; their cervical dilatation levels at arrival were more; and their birth fear (latent, active, transition phase), birth pain (latent, active phase), satisfaction with the delivery and being ready for the delivery points were lower. The use of antenatal education program in the antenatal period is recommended to decrease the birth fear and the delivery pain, shorten the delivery duration, increase the satisfaction with the delivery point.
Analysis Of White Jellyfish (Aurelia Aurita) Processing Business In CV. Almahaera In Puupi Village Of Kolono Districct Of South Konawe Regency
Authors: Wahyuningsih Ayu Putri , Sarinah Sarinah , Syukri Muhammad
Published: November 2022

This research aims to find out the process analysis of white jellyfish (aurelia aurita) processing business in cv. almahaera in puupi village of kolono districct of south konawe regency. Determination of the location of the study is done intentionally (purposive). Data collection is done by observation, interview and documeation methods. Respondents in the study were business owners, secretaries and several employees at jellyfish processing companies (Aurelia aurita). The study was analyzed using income analysis. The results showed that the variable total cost of production was produced by a production value of Rp957,435,000, total receipts of Rp2,430,400,000, total revenue of Rp 1,472,965,000 and R/C Ratio of 2.54.
Modified spectral conjugate gradient iterative scheme for unconstrained optimization problems with application on COVID-19 model
Authors: Novkaniza Fevi , Malik Maulana , Sulaiman Ibrahim Mohammed , Aldila Dipo
Published: November 2022

In this work, a new class of spectral conjugate gradient (CG) method is proposed for solving unconstrained optimization models. The search direction of the new method uses the ZPRP and JYJLL CG coefficients. The search direction satisfies the descent condition independent of the line search. The global convergence properties of the proposed method under the strong Wolfe line search are proved with some certain assumptions. Based on some test functions, numerical experiments are presented to show the proposed method's efficiency compared with other existing methods. The application of the proposed method for solving regression models of COVID-19 is provided.

Mathematics subject classification

65K10, 90C52, 90C26.
Lithium doped biphasic calcium phosphate: Structural analysis and osteo/odontogenic potential in vitro
Authors: Yoo Kyung-Hyeon , Kim Yeon , Kim Yong-Il , Bae Moon-Kyoung , Yoon Seog-Young
Published: November 2022

Biphasic calcium phosphate (BCP) is generally considered a good synthetic bone graft material with osteoinductive potential. Lithium ions are trace elements that play a role in the bone-remodeling process. This study aimed to investigate the effects of lithium ions on the phase, crystal structure, and biological responses of lithium doped BCPs and to identify improvements in their osteogenic properties. Lithium-doped BCP powders with different doping levels (0, 5, 10, and 20 at%) were synthesized via the co-precipitation method. We found that the four types of lithium-doped BCP powders showed different phase compositions of hydroxyapatite and β-tricalcium phosphate. In addition, lithium ions favored entering the β-tricalcium phosphate structure at the Ca (4) sites and calcium vacancy sites [VCa(4)] up to 10 at%. This substitution improves the crystal stabilization by filling the vacancies with Ca2+ and Li+ in all Ca sites. However, when the concentration of Li ions was higher than 10 at%, lithium-induced crystal instability resulted in the burst release of lithium ions, and the osteogenic behavior of human dental pulp stem cells did not improve further. Although lithium ions regulate osteogenic properties, it is important to determine the optimal amount of lithium in BCPs. In this study, the most effective lithium doping level in BCP was approximately 10 at% to improve its biological properties and facilitate medical applications.
Characterization of carotenoids in Lycium barbarum fruit by using UPC2-PDA-Q-TOF-MSE couple with deep eutectic solvents extraction and evaluation of their 5α-reductase inhibitory activity
Authors: Yu Zhonglian , Xia Mengqin , Li Xueping , Wang Rui , Liu Wenjing , Zheng Ruirong , Wang Zhengtao , Yang Li , Shi Yanhong
Published: November 2022

Carotenoids from Lycium barbarum fruits have possessed pharmacological efficacy against eye diseases, cardiovascular disorders, cancer, and benign prostatic hyperplasia. However, the efficient extraction, rapid characterization and activities evaluation of Lycium carotenoids remains a challenge. To concentrate and characterize Lycium carotenoids, we have developed ultrasound-assisted extraction methods with different deep eutectic solvents (DESs) and analyzed carotenoids by ultra-performance convergence chromatography coupled with photo diode array detector and quadrupole time-of-flight mass spectrometry (UPC2-PDA-Q-TOF-MSE). DESs containing choline chloride and malonic acid presented better extraction efficiency and were more environmentally friendly than other extraction methods. Carotenoids were more quickly profiled (in 11 min) by UPC2 compared to by UPLC (in 35 min), with seventeen main peaks were characterized in the MS fragmentation patterns. The in vitro 5α-reductase inhibitory activity of DESs extracts, fractions and components were subsequently assessed, and the predominant component zeaxanthin dipalmitate (ZD) exhibited potent inhibitory activity. Our study provides a chemical and pharmacological basis for the further development of potential new drugs based on Lycium carotenoids.
Defect chemistry of electrocatalysts for CO2 reduction
Authors: Li Hongqiang , Li Ran , Niu Jiabao , Gan Kaining , He Xiaojun
Published: November 2022

Electrocatalytic CO2 reduction is a promising strategy for converting the greenhouse gas CO2 into high value-added products and achieving carbon neutrality. The rational design of electrocatalysts for CO2 reduction is of great significance. Defect chemistry is an important category for enhancing the intrinsic catalytic performance of electrocatalysts. Defect engineering breaks the catalytic inertia inherent in perfect structures by imparting unique electronic structures and physicochemical properties to electrocatalysts, thereby improving catalytic activity. Recently, various defective nanomaterials have been studied and show great potential in electrocatalytic CO2 reduction. There is an urgent need to gain insight into the effect of defects on catalytic performance. Here, we summarized the recent research advances on the design of various types of defects, including carbon-based materials (intrinsic defects, heteroatom doping and single-metal-atom sites) and metal compounds (vacancies, grain boundaries, and lattice defects). The major challenges and prospects of defect chemistry in electrocatalytic CO2 reduction are also proposed. This review is expected to be instructive in the development of defect engineering for CO2 reduction catalysts.
Sea surface height fluctuations relevant to Indian summer monsoon over the northwestern Indian Ocean
Authors: Zhang Xiaolin , Mochizuki Takashi
Published: November 2022

We examined the interannual variations in sea surface height (SSH) over the northwestern Indian Ocean during 1993–2016, by using in situ observations along the east coast of the Arabian Peninsula together with satellite observations, objective analysis, and reanalysis. Focusing on the impacts of the Indian summer monsoon relative to the El Niño Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD) modes, we found that the monsoon predominantly controls the summertime SSH variations at the in situ observatories, consistent with satellite observations. The monsoon is closely related to the SSH at a specific observatory in almost all seasons, whereas the wintertime SSH is strongly influenced by ENSO and IOD at other observatories. These SSH variations with local modulations in the coastal area were accompanied by basin-scale variations. The reduced southwesterly monsoon wind, for example, is found with the reduced ocean upwelling narrowly confined near the coast and the upper ocean temperature rise implying reduced meridional heat transport over the south of the Arabian Peninsula.
Modulation of sea surface temperature in three oceans on precipitation increase over Northwest China during the past 60 years: A review
Authors: Ding Yihui , Wu Ping , Liu Yanju
Published: November 2022

Northwest China is a typical arid and semi-arid region that is part of Central Asia. However, during the past 60 years, the climate in Northwest China has shown a warm and humid trend, with both average and extreme precipitation continuing to increase. Humidification in Northwest China is mainly caused by anomalous westward water vapor transport. Change in the water vapor transport path is directly related to the Mongolian anticyclone anomaly and weakening of the Asian summer monsoon. Our research shows that interdecadal changes in sea surface temperature (SST) in the North Atlantic, North Pacific, and Indian oceans, play an important role in interdecadal adjustment of atmospheric circulation and the wetting climate over Northwest China. Since the 1980s, the Indian Ocean has been warming continuously, and the land–sea thermal gradient has weakened, resulting in a significant reduction in water vapor transport of the Asian summer monsoon. In contrast, anomalous northerly water vapor transport from the polar region increased. Concurrently, SST over the North Atlantic is also warming, and the Atlantic multidecadal oscillation (AMO) changes from the negative to positive phase, triggering anomalous anticyclones over Mongolia, which also leads to weakening of the Asian summer monsoon. Therefore, eastern China is affected by abnormal northeast winds. These northeast winds can continuously transport water vapor to the western region of China, leading to the prevalence of easterly winds in Northwest China. Moreover, Pacific decadal oscillation (PDO) changed from the positive to negative phase after the 1990s, which promoted the East Asian westerly jet to move to the Arctic and produce easterly anomalies in East Asia and Northwest China. Interdecadal changes in SST over the Indian, North Atlantic, and North Pacific Oceans all have reduced summer water vapor from the Indian Ocean. However, water vapor from the North Pacific and high latitudes (including the polar region) can be transported to Northwest China through easterly anomalies, resulting in increased precipitation and climate humidification.
Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation
Authors: Ge Junye , Han Wenqiang , Ma Chuanzhen , Chen Tongshuai , Liu Huiyu , Maduray Kellina , Qu Yinan , Li Yihan , Hu Tong , Wang Qinhong , Zhong Jingquan
Published: November 2022

Background

Acetaldehyde dehydrogenase 2 (ALDH2) is an essential enzyme in alcohol metabolism, playing a vital function in resisting oxidative stress. Lots of gene variants have been associated with atrial fibrillation (AF), among which the association between ALDH2 rs671 polymorphism and AF is variable. This study aimed to investigate the relationship between ALDH2 rs671 polymorphism and AF occurrence or progression and AF recurrence after catheter ablation.

Methods

A total of 924 subjects were enrolled in the study. The ALDH2 genotypes are composed of wild-type homozygotes (ALDH2*1/*1), heterozygotes (ALDH2*1/*2), and mutant homozygotes (ALDH2*2/*2), in which the genotypes ALDH2*1/*2 and ALDH2*2/*2 are combined into the ALDH2*2. Univariate and multivariate logistic regression analyses were performed to investigate the association between ALDH2*2 and AF occurrence and progression. COX regression analysis was used to explore the association of ALDH2*2 with AF recurrence after catheter ablation.

Results

The prevalence of AF differed significantly between the ALDH2*2 group (102/251) and ALDH2*1/*1 group (330/673) (P = 0.023). For AF occurrence, in the univariate analysis, alcohol consumption was a risk factors (OR: 1.503, P = 0.003), whereas ALDH2*2 was a protective factor (OR: 0.712, P = 0.023). In the multivariate analysis, alcohol consumption (P = 0.156) and ALDH2*2 (P = 0.096) were no longer independent factors. ALDH2*2 with non-drinking was associated with a decreased AF occurrence (OR: 0.65, P = 0.021), whereas ALDH2*2 with drinking was not (P = 0.365). For AF progression, multivariate analysis revealed ALDH2*2 could promote persistent AF in female AF patients (OR: 2.643, P = 0.008). Cox regression analysis suggested that ALDH2*2 (P = 0.752) was not a risk factor for AF recurrence after catheter ablation during a median 6 months follow-up.

Conclusion

While ALDH2*2 was not directly related to AF, ALDH2*2 with non-drinking was associated with a decreased incidence of AF. ALDH2*2 may accelerate AF progression in female patients, increasing the likelihood of developing persistent AF. Therefore, individuals with ALDH2*2 should refrain from consuming alcohol to decrease the onset and progression of AF.
Association between SEMA3A signaling pathway genes and BMD/OP risk: An epidemiological and experimental study
Authors: Zhou Hao-long , Wei Mu-hong , Di Dong-sheng , Zhang Ru-yi , Zhang Jian-li , Yuan Ting-ting , Liu Qian , Zhou Ting-ting , Huang Qin , Wang Qi
Published: November 2022

Objective

This study aimed to explore the associations of genetic variants in the semaphorin 3A (SEMA3A) signaling pathway genes, including SEMA3A, NRP1, PLXNA1, PLXNA2 and PLXNA3 with osteoporosis (OP) risk and bone mineral density (BMD) in a Chinese Han older adult population.

Study design and method

A two-stage design was adopted. Total of 47.8kb regions in the 5 genes were sequenced using targeted next-generation sequencing (NGS) technology in the discovery stage, and the discovered OP-related single nucleotide polymorphisms (SNPs) were further genotyped using improved multiple linkage detection reaction technique in the validation stage. Methods of ALP/TRAP staining, real-time fluorescent quantitative PCR, and cell proliferation and apoptosis assays were performed with MC3T3-E1 and RAW 264.7 cell lines to clarify biological effects of observed functional variants in cell lines responsible for bone mass remodeling.

Results

Total of 400 postmenopausal women (211 OP cases) were involved in the discovery stage, where 6 common and 4 rare genetic variants were found to be associated with OP risk. In the validation stage among another 859 participants (417 women, 270 OP cases), the PLXNA2 rs2274446 T allele was associated with reduced OP risk and increased femoral neck (FN) BMD compared to the C allele. Moreover, significant associations of NRP1 rs2070296 with FN BMD/OP risk and of NRP1 rs180868035 with lumbar spine and FN BMDs were also observed in the combination dataset analysis. Compared to the osteoblasts/osteoclasts transfected with the wild-type NRP1 rs180868035, those transfected with the mutant-type had reduced mRNA expression of osteoblastic genes (i.e., ALP, RUNX2, SP7 and OCN), while elevated mRNA expression of osteoclastic genes (i.e., TRAP, NFATc1 and CTSK). Furthermore, mutant NRP1 rs180868035 transfection inhibited osteoblast proliferation and osteoclast apoptosis, while promoted osteoclast proliferation and osteoblast apoptosis in corresponding cell lines.

Conclusion

Genetic variants located in NRP1 and PLXNA2 genes were associated with OP risk and BMD. The NRP1 rs180868035 affects bone metabolism by influencing osteoblasts and osteoclasts differentiation, proliferation and apoptosis.
The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort
Authors: Ivell Richard , Heng Kee , Severn Katie , Antonio Leen , Bartfai Gyorgy , Casanueva Felipe F. , Huhtaniemi Ilpo T. , Giwercman Aleksander , Maggi Mario , O’Connor Daryl B. , O’Neill Terence W. , Punab Margus , Rastrelli Giulia , Slowikowska-Hilczer Jolanta , Tournoy Jos , Vanderschueren Dirk , Wu Frederick C. W. , Anand-Ivell Ravinder
Published: November 2022

Background

Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation status.

Objectives

To determine the ability of INSL3 to predict hypogonadism and age-related morbidity using the EMAS cohort of older community-dwelling men.

Materials & methods

Circulating INSL3 was assessed in the EMAS cohort and its cross-sectional and longitudinal relationships to hypogonadism, here defined by testosterone (T) <10.5nmol/l, and a range of age-related morbidities determined by correlation and regression analysis.

Results & discussion

While INSL3 is an accurate measure of primary hypogonadism, secondary and compensated hypogonadism also indicate reduced levels of INSL3, implying that testicular hypogonadism does not improve even when LH levels are increased, and that ageing-related hypogonadism may combine both primary and secondary features. Unadjusted, serum INSL3, like calculated free testosterone (cFT), LH, or the T/LH ratio reflects hypogonadal status and is associated with reduced sexual function, bone mineral density, and physical activity, as well as increased occurrence of hypertension, cardiovascular disease, cancer, and diabetes. Using multiple regression analysis to adjust for a range of hormonal, anthropometric, and lifestyle factors, this relationship is lost for all morbidities, except for reduced bone mineral density, implying that INSL3 and/or its specific receptor, RXFP2, may be causally involved in promoting healthy bone metabolism. Elevated INSL3 also associates with hypertension and cardiovascular disease. When unadjusted, INSL3 in phase 1 of the EMAS study was assessed for its association with morbidity in phase 2 (mean 4.3 years later); INSL3 significantly predicts 7 out of 9 morbidity categories, behaving as well as cFT in this regard. In contrast, total T was predictive in only 3 of the 9 categories.

Conclusion

Together with its low within-individual variance, these findings suggest that assessing INSL3 in men could offer important insight into the later development of disease in the elderly.
Predicting peak day and peak hour of electricity demand with ensemble machine learning
Authors: Fu Tao , Zhou Huifen , Ma Xu , Hou Z. Jason , Wu Di
Published: November 2022

Battery energy storage systems can be used for peak demand reduction in power systems, leading to significant economic benefits. Two practical challenges are 1) accurately determining the peak load days and hours and 2) quantifying and reducing uncertainties associated with the forecast in probabilistic risk measures for dispatch decision-making. In this study, we develop a supervised machine learning approach to generate 1) the probability of the next operation day containing the peak hour of the month and 2) the probability of an hour to be the peak hour of the day. Guidance is provided on preparation and augmentation of data as well as selection of machine learning models and decision-making thresholds. The proposed approach is applied to the Duke Energy Progress system and successfully captures 69 peak days out of 72 testing months with a 3% exceedance probability threshold. On 90% of the peak days, the actual peak hour is among the 2 h with the highest probabilities.
Evaluating resource utilization efficiency in urban land construction of Yangtze river economic zone under technological progress
Authors: Wei Wei , Qian Xiaoyan , Lin Qing , Zheng Qiongjie , Cao Yu , Chen Xiding
Published: November 2022

Based on the economic models of DEA-Malmquist, this paper estimated the land utilization efficiency by considering dimensions such as energy, water and economic inputs in the Yangtze River Delta urban agglomeration from 2004 to 2016, and analyzed its spatial and temporal evolution pattern and characteristics. Then use the Tobit model to explore the main influencing factors, and examine the contribution of each influencing factor, such as technical progress. The research results show that the urban construction efficiency and the distance from the port have a “∽” curve relationship, verifying the “center-periphery” theory of new economic geography. It is also found that the effective radiation distance of the current economic center Shanghai to the surrounding area is 361.5 km. The structural analysis of the efficiency of construction land shows that the market mechanism has not played a fundamental role in the allocation of construction land resources, the improvement of the quality of labor force, and the expansion of capital clustering with industry is the main driving factor to support the efficiency of construction land use in the Yangtze River Delta region. We suggest that more efforts will be needed to reform market mechanisms and improve technological progress in the near future.
Study on multidimensional changes of rainfall erosivity during 1970–2017 in the North–South Transition Zone, China
Authors: Li Li , Zhu Wenbo , Liu Junjie , Zhang Li , Zhu Lianqi , Wang Liyuan , Chen Chaonan , Ahmed Naveed , Gurung Sher Bahadur
Published: November 2022

China is one of the world’s most seriously affected regions by water and soil erosion. Soil erosion is a major cause and an important component of land degradation, which has a negative impact on ecological protection and sustainable socioeconomic development. Rainfall erosivity (RE) is one of the key parameters to assess the degree of soil erosion. Quantifying the content of RE and the formation mechanism is important to accurately measure the degree of soil erosion and provide a theoretical basis for soil erosion management. Here, this study analyzed the spatial and temporal characteristics of RE and their driving mechanisms in the Qinba Mountains from 1970 to 2017 using a daily rainfall model. Furthermore, geographical detector methods were used to quantitatively identify the dominant factors affecting RE and the dominant factors affecting RE on different topographic reliefs. The results showed that the RE between 1970 and 2017 averaged 4,197.85 MJ mm hm−2 h−1 a−1, with a mutation coefficient of 0.16. The spatial distribution of RE is high in the southeast and low in the northwest, and the mean annual RE declines with the increase in latitude in longitude and increases with the reduction in longitude in latitude. In addition, precipitation and temperature are the main factors affecting the spatial distribution of RE. Among these, precipitation can explain about 97% of the RE and temperature can explain about 65% of the RE. These findings should be essential for managing soil and water loss in the North–South Transition Zone, China.
Innovative governance systems and green innovations of agriculture-related enterprises based on the approach of fuzzy-set qualitative comparative analysis
Authors: Bao Huricha , Chen Chibo , Liu Yuemin
Published: November 2022

The green innovation (GI) of agriculture-related enterprises has been an important factor to the ecological and sustainable development of agriculture. This research integrates the eight elements of the internally and externally governing mechanisms in the innovative governance system (IGS), adopts the fuzzy-set qualitative comparative analysis (fsQCA) from the configuration perspective, taking the data of A-shares’ listed agricultural companies in Shanghai and Shenzhen stock markets from 2007 to 2019 as samples, and explores the configuration effects of highly green innovations (GIs) from the collaborative matching of various elements of the enterprises’ IGS. The research results showed that 1) a single element of this IGS was unable to become a requisite for agriculture-related enterprises to generate highly GIs, but government subsidies played a more universal role in such a process; 2) the “multiple synergies” of various elements in the enterprises’ IGS formed six different configurations to drive highly GIs, namely, three major models of internal and external supervision with an external incentive, internal supervision with internal and external incentives, and internal and external supervision with internal and external incentives; 3) there were five different paths for the IGS of agriculture-related enterprises to generate non-highly GIs, which were in asymmetry with the configuration paths to generate the highly GIs.
Simulation of citrus production space based on MaxEnt
Authors: Lin Zhengyu , Chen Chunyan , Liu Yuanli , Liu Guanghui , He Peng , Liao Guitang , Gao Wenbo , Cao Ji , Shao Zhouling
Published: November 2022

Crop production space is the most important part of land use system, and spatial simulation has always been the key task of land science. Crop production space is affected by many factors on different spatio-temporal scales, which leads to the complexity of simulation models. The existing simulation models also have the limitations of lack of human factors, large simulation area and excessive reliance on expert experience. Sichuan Province is a typical area of Citrus spatial expansion in China, so it is of great practical significance to carry out spatial regulation. From the comprehensive perspective of nature and humanity, this research uses MaxEnt, ArcGIS, Orcale, SQL to design a spatial regulation method (CSSM) for citrus, predict the citrus production space in Sichuan Province in 2025, and put forward regulation suggestions. The results showed that the citrus spatial simulation method better reflects the comprehensive effect of natural and human factors on crop space, and realizes the research on the regulation of single crop production space. The dominant environmental variables affecting citrus production in Sichuan are input of production factors, society, climate and terrain. Human activities play a leading role. The suitable environment for citrus production in Sichuan is: elevation ≤500m, annual average temperature ≥16.5 °C, aspect are northeast, southwest and northwest, supported by preferential policies, the input of Citrus fertilizer in the county is ≥ 500t, the input of Citrus labor in the county is ≥ 5,000, the input of Citrus pesticide in the county is ≥ 12.5t, and the technical progress represented by unit yield is 750–7000 t/km2. The suitable space for citrus production in Sichuan are mainly located in Zigong, Nanchong, Ziyang, Neijiang, Meishan, Leshan, Yibin and Luzhou. The government should choose a positive low growth scenario to stabilize the citrus area in Sichuan at 3533 km2 in 2025, and form a major citrus production area in Meishan, Ziyang, Neijiang, Chengdu, Nanchong and Yibin.
Utilization of ferulic acid in Aspergillus niger requires the transcription factor FarA and a newly identified Far-like protein (FarD) that lacks the canonical Zn(II)2Cys6 domain
Authors: Arentshorst Mark , Reijngoud Jos , van Tol Daan J. C. , Reid Ian D. , Arendsen Yvonne , Pel Herman J. , van Peij Noël N. M. E. , Visser Jaap , Punt Peter J. , Tsang Adrian , Ram Arthur F. J.
Published: November 2022

The feruloyl esterase B gene (faeB) is specifically induced by hydroxycinnamic acids (e.g. ferulic acid, caffeic acid and coumaric acid) but the transcriptional regulation network involved in faeB induction and ferulic acid metabolism has only been partially addressed. To identify transcription factors involved in ferulic acid metabolism we constructed and screened a transcription factor knockout library of 239 Aspergillus niger strains for mutants unable to utilize ferulic acid as a carbon source. The ΔfarA transcription factor mutant, already known to be involved in fatty acid metabolism, could not utilize ferulic acid and other hydroxycinnamic acids. In addition to screening the transcription factor mutant collection, a forward genetic screen was performed to isolate mutants unable to express faeB. For this screen a PfaeB-amdS and PfaeB-lux613 dual reporter strain was engineered. The rationale of the screen is that in this reporter strain ferulic acid induces amdS (acetamidase) expression via the faeB promoter resulting in lethality on fluoro-acetamide. Conidia of this reporter strain were UV-mutagenized and plated on fluoro-acetamide medium in the presence of ferulic acid. Mutants unable to induce faeB are expected to be fluoro-acetamide resistant and can be positively selected for. Using this screen, six fluoro-acetamide resistant mutants were obtained and phenotypically characterized. Three mutants had a phenotype identical to the farA mutant and sequencing the farA gene in these mutants indeed showed mutations in FarA which resulted in inability to growth on ferulic acid as well as on short and long chain fatty acids. The growth phenotype of the other three mutants was similar to the farA mutants in terms of the inability to grow on ferulic acid, but these mutants grew normally on short and long chain fatty acids. The genomes of these three mutants were sequenced and allelic mutations in one particular gene (NRRL3_09145) were found. The protein encoded by NRRL3_09145 shows similarity to the FarA and FarB transcription factors. However, whereas FarA and FarB contain both the Zn(II)2Cys6 domain and a fungal-specific transcription factor domain, the protein encoded by NRRL3_09145 (FarD) lacks the canonical Zn(II)2Cys6 domain and possesses only the fungal specific transcription factor domain.