bluuebunny/crossref_metadata_2025 huggingface dataset:
“County-to-City Upgrading” Policy and Firm Innovation—Evidence from China
Authors: Song Yida
Published: June 2024

The “County-to-City Upgrading” policy represents a typical tool for central and local governments to promote the urbanization process through administrative empowerment. Do local governments’ policies promote innovation-driven high-quality and sustainable development? Under the context of the high-quality development of China’s economy, this paper examines the quantitative impact of the local governments’ “County-to-City Upgrading” policy on enterprises’ innovation. Using a staggered-DID model and the data from the Chinese Patent Database and the Industrial Enterprise Database from 2000 to 2013, the baseline results indicate that the policy not only increases the quantity of innovation but also improves the quality of innovation. The key findings of the research are the following: (1) The policy primarily promotes innovation activities among local enterprises through the cost reduction effect and resource accumulation effect. (2) The policy has a more significant impact on boosting innovation in the eastern regions as well as areas with stronger intellectual property protection. (3) The policy not only can advance technological and practical innovation but can also help enterprises overcome the problem of technological containment. (4) The policy has a prominent impact on green and low-carbon patents, which implies that it has become a significant drive pushing forward local green and sustainable development.
Integration of Methane Reforming and Chemical Looping Technologies for Power Generation from Waste Plastic: Technical and Economic Assessment
Authors: Alqarzaee Faisal , Ahmed Usama
Published: June 2024

An imperative environmental concern is escalating due to the widespread disposal of plastic waste in oceans and landfills, adversely impacting ecosystems and marine life. In this context, sustainable methods for plastic waste utilisation were evaluated, particularly for power generation. Two case studies were developed to assess the potential utilisation of waste plastic, specifically polyethylene and polypropylene, by integrating gasification with steam methane reforming (SMR) alongside two oxygen-supplying techniques for combustion including cryogenic air separation (ASU) and chemical looping combustion (CLC) for case 1 and case 2, respectively. For this, thorough process simulations of both case studies were performed to obtain detailed material and energy balances. The techno-economic analysis was performed to assess the economic performance of the processes by estimating levelized cost of electricity (LCOE). The results indicated that case 2 is more efficient (5.4%) due to the lower utility requirement of the CLC process as compared to ASU. Consequently, case 2 generated a LCOE of USD 137/MW. It was also seen from the results that the power output is directly proportional to the methane input while the increase in gasifier temperature enhances the H2 and CO content in syngas.
On Symmetries of Integrable Quadrilateral Equations
Authors: Cheng Junwei , Liu Jin , Zhang Da-jun
Published: June 2024

In the paper, we describe a method for deriving generalized symmetries for a generic discrete quadrilateral equation that allows a Lax pair. Its symmetry can be interpreted as a flow along the tangent direction of its solution evolving with a Lie group parameter t. Starting from the spectral problem of the quadrilateral equation and assuming the eigenfunction evolves with the parameter t, one can obtain a differential-difference equation hierarchy, of which the flows are proved to be commuting symmetries of the quadrilateral equation. We prove this result by using the zero-curvature representations of these flows. As an example, we apply this method to derive symmetries for the lattice potential Korteweg–de Vries equation.
A New LCL Filter Design Method for Single-Phase Photovoltaic Systems Connected to the Grid via Micro-Inverters
Authors: Adamas-Pérez Heriberto , Ponce-Silva Mario , Mina-Antonio Jesús Darío , Claudio-Sánchez Abraham , Rodríguez-Benítez Omar , Rodríguez-Benítez Oscar Miguel
Published: June 2024

This paper aims to propose a new sizing approach to reduce the footprint and optimize the performance of an LCL filter implemented in photovoltaic systems using grid-connected single-phase microinverters. In particular, the analysis is carried out on a single-phase full-bridge inverter, assuming the following two conditions: (1) a unit power factor at the connection point between the AC grid and the LCL filter; (2) a control circuit based on unipolar sinusoidal pulse width modulation (SPWM). In particular, the ripple and harmonics of the LCL filter input current and the current injected into the grid are analyzed. The results of the Simulink simulation and the experimental tests carried out confirm that it is possible to considerably reduce filter volume by optimizing each passive component compared with what is already available in the literature while guaranteeing excellent filtering performance. Specifically, the inductance values were reduced by almost 40% and the capacitor value by almost 100%. The main applications of this new design methodology are for use in single-phase microinverters connected to the grid and for research purposes in power electronics and optimization.
Using the Multicomponent Aerosol FORmation Model (MAFOR) to Determine Improved VOC Emission Factors in Ship Plumes
Authors: Fink Lea , Karl Matthias , Matthias Volker , Weigelt Andreas , Irjala Matti , Simonen Pauli
Published: June 2024

International shipping’s particulate matter primary emissions have a share in global anthropogenic emissions of between 3% and 4%. Ship emissions of volatile organic compounds (VOCs) can play an important role in the formation of fine particulate matter. Using an aerosol box model for the near-plume scale, this study investigated how the changing VOC emission factor (EF) for ship engines impacts the formation of secondary PM2.5 in ship exhaust plumes that were detected during a measurement campaign. The agreement between measured and modeled particle number size distribution was improved by adjusting VOC emissions, in particular of intermediate-, low-, and extremely low-volatility compounds. The scaling of the VOC emission factor showed that the initial emission factor, based on literature data, had to be multiplied by 3.6 for all VOCs. Information obtained from the box model was integrated into a regional-scale chemistry transport model (CTM) to study the influence of changed VOC ship emissions over the Mediterranean Sea. The regional-scale CTM run with adjusted ship emissions indicated a change in PM2.5 of up to 5% at the main shipping routes and harbor cities in summer. Nevertheless, overall changes due to a change in the VOC EF were rather small, indicating that the size of grid cells in CTMs leads to a fast dilution.
Recent Progress on Physiologically Based Pharmacokinetic (PBPK) Model: A Review Based on Bibliometrics
Authors: Huang He , Zhao Wenjing , Qin Ning , Duan Xiaoli
Published: June 2024

Physiologically based pharmacokinetic/toxicokinetic (PBPK/PBTK) models are designed to elucidate the mechanism of chemical compound action in organisms based on the physiological, biochemical, anatomical, and thermodynamic properties of organisms. After nearly a century of research and practice, good results have been achieved in the fields of medicine, environmental science, and ecology. However, there is currently a lack of a more systematic review of progress in the main research directions of PBPK models, especially a more comprehensive understanding of the application in aquatic environmental research. In this review, a total of 3974 articles related to PBPK models from 1996 to 24 March 2024 were collected. Then, the main research areas of the PBPK model were categorized based on the keyword co-occurrence maps and cluster maps obtained by CiteSpace. The results showed that research related to medicine is the main application area of PBPK. Four major research directions included in the medical field were “drug assessment”, “cross-species prediction”, “drug–drug interactions”, and “pediatrics and pregnancy drug development”, in which “drug assessment” accounted for 55% of the total publication volume. In addition, bibliometric analyses indicated a rapid growth trend in the application in the field of environmental research, especially in predicting the residual levels in organisms and revealing the relationship between internal and external exposure. Despite facing the limitation of insufficient species-specific parameters, the PBPK model is still an effective tool for improving the understanding of chemical–biological effectiveness and will provide a theoretical basis for accurately assessing potential risks to ecosystems and human health. The combination with the quantitative structure–activity relationship model, Bayesian method, and machine learning technology are potential solutions to the previous research gaps.
Demographic and Geographic Trends in Gunshot Wound-Associated Orthopedic Injuries among Children, Adolescents, and Young Adults in New York State from 2016–2020
Authors: Lin Charles C. , Shankar Dhruv S. , Anil Utkarsh , Carter Cordelia W.
Published: June 2024

Background: The purpose of this study was to investigate temporal trends in gunshot wound (GSW)-associated orthopedic injuries among children, adolescents, and young adults in New York State, and to determine the impact of the onset of the COVID-19 pandemic on the incidence of these injuries. Methods: The New York Statewide Planning and Research Cooperative System (SPARCS) inpatient database was reviewed to identify patients ≤ 21 years of age who presented to a hospital with GSW-associated injuries from January 2016 to December 2020. Patient diagnosis codes were cross-referenced with the list of the International Classification of Diseases Version 10 Clinical Modification (ICD-10-CM) codes for orthopedic injuries to determine the incidence of GSW-associated orthopedic injuries among this cohort. The number of cases was cross-referenced with New York State census population estimates to calculate incidence per million. The geographic incidence was plotted over a map of New York State with sub-division based on facility Zone Improvement Plan (ZIP) codes. Poisson regression was used to compare the injury incidence in 2020 (pandemic onset) versus the preceding years (pre-pandemic). Results: Between 2016 and 2020, there were 548 inpatient admissions for GSW-associated orthopedic injuries, representing an incidence of 5.6 cases per million. Injury incidence decreased from 2016 to 2019, with an increase in 2020 representing almost 28% of the total cases identified. There was a statistically significant difference in the incidence rate ratio for 2020 compared to 2016–2019 (p < 0.001). The majority of patients were male (94%), African–American (73%), and covered by either Medicare (49%) or Managed Care (47%). Most cases were clustered around large metropolitan areas with low incidence in suburban and rural regions of the state. Conclusions: There was a two-fold increase in the incidence of GSW-associated orthopedic injuries among patients ≤ 21 years old in New York State during the onset of the COVID-19 pandemic.
Altitude Heterogeneity of Magnetic Fields and Doppler Velocities in the Area of Seismic Source of a Strong Solar Flare from Data in Helium, Sodium, and Nickel Lines
Authors: Yakovkin Ivan I. , Lozitska Natalia I. , Lozitsky Vsevolod G.
Published: June 2024

Measurements of magnetic fields near seismic sources during solar flares are vital for understanding the dynamics of solar activity. We used spectropolarimetric observations of the X17.2/4B solar flare on 28 October 2003, over a wavelength interval of 43 Å, including the D3, D2, D1, and Ni I 5892.88 Å lines, to analyze the Stokes I ± V profiles. Effective magnetic fields within 0.5–1.5 kG were measured in the D1, D2, and D3 lines at different flare locations, with the photospheric Ni I 5892.88 Å line showing a weaker field of below 0.5 kG. The D3 line showed rapid plasma descents of up to 11 km/s, in contrast to the slower velocities within 2.3 km/s observed in other lines. The differing amplitudes in the I + V and I − V profiles indicated potential non-Zeeman polarization effects. Secondary Stokes V peaks were also detected up to 8 Å from the D3 emission core. Significant altitudinal inhomogeneity in the magnetic field strengths was detected, possibly indicating the local magnetic collapse, facilitating the Lorentz-force driven mechanism of the seismic source excitation.
A Systematic Assessment of Greening Interventions for Developing Best Practices for Urban Heat Mitigation—The Case of Huế, Vietnam
Authors: Scheuer Sebastian , Sumfleth Luca , Nguyen Long Dac Hoang , Vo Ylan , Hoang Thi Binh Minh , Jache Jessica
Published: June 2024

The health of urban populations is increasingly at risk due to the amplification and chronification of urban heat stress by climate change. This is particularly true for urban environments in humid tropical climates, including many cities in Southeast Asia. It is also in these locations where increasing climatic risks may be exacerbated by urban growth, underscoring the need to develop effective mitigation strategies for strengthening urban resilience and supporting climate change adaptation. Conservation and widespread implementation of green infrastructure (GI) are regarded as one means to counter heat as a public health threat. However, for lower-income countries across Southeast Asia, such as Vietnam, knowledge gaps remain with respect to the effectiveness of greening interventions for heat mitigation. To address this gap, in the context of urban expansion in the humid tropical city of Huế, Vietnam, diurnal cooling potential and regulation of outdoor thermal comfort (OTC) within a wide, shallow street canyon were systematically assessed for selected elements of GI along a quantitative and qualitative dimension using ENVI-met. Tree-based interventions were found to be most effective, potentially decreasing UTCI by −1.9 K at the domain level. Although lower in magnitude, green verges and green facades were also found to contribute to OTC, with green verges decreasing UTCI by up to −1.7 K and green facades by up to −1.4 K locally. Potential synergistic cooling impacts were identified through a combination of GI elements. However, no scenario was found to decrease heat stress to zero or moderate levels. Substantially reducing heat stress may thus require further measures and a closer consideration of local morphological characteristics.
Development and Validation of an Enzyme-Linked Immunosorbent Assay-Based Protocol for Evaluation of Respiratory Syncytial Virus Vaccines
Authors: Nham Eliel , Jang A-Yeung , Ji Hyun Jung , Ahn Ki Bum , Bae Joon-Yong , Park Man-Seong , Yoon Jin Gu , Seong Hye , Noh Ji Yun , Cheong Hee Jin , Kim Woo Joo , Seo Ho Seong , Song Joon Young
Published: June 2024

Recently, respiratory syncytial virus (RSV) vaccines based on the prefusion F (pre-F) antigen were approved in the United States. We aimed to develop an enzyme-linked immunosorbent assay (ELISA)-based protocol for the practical and large-scale evaluation of RSV vaccines. Two modified pre-F proteins (DS-Cav1 and SC-TM) were produced by genetic recombination and replication using an adenoviral vector. The protocol was established by optimizing the concentrations of the coating antigen (pre-F proteins), secondary antibodies, and blocking buffer. To validate the protocol, we examined its accuracy, precision, and specificity using serum samples from 150 participants across various age groups and the standard serum provided by the National Institute of Health. In the linear correlation analysis, coating concentrations of 5 and 2.5 μg/mL of DS-Cav1 and SC-TM showed high coefficients of determination (r > 0.90), respectively. Concentrations of secondary antibodies (alkaline phosphatase-conjugated anti-human immunoglobulin G, diluted 1:2000) and blocking reagents (5% skim milk/PBS-T) were optimized to minimize non-specific reactions. High accuracy was observed for DS-Cav1 (r = 0.90) and SC-TM (r = 0.86). Further, both antigens showed high precision (coefficient of variation < 15%). Inhibition ELISA revealed cross-reactivity of antibodies against DS-Cav1 and SC-TM, but not with the attachment (G) protein.
Epidemiological and Genetic Characteristics of Respiratory Viral Coinfections with Different Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Authors: Trifonova Ivelina , Korsun Neli , Madzharova Iveta , Alexiev Ivailo , Ivanov Ivan , Levterova Viktoria , Grigorova Lyubomira , Stoikov Ivan , Donchev Dean , Christova Iva
Published: June 2024

This study aimed to determine the incidence and etiological, seasonal, and genetic characteristics of respiratory viral coinfections involving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Between October 2020 and January 2024, nasopharyngeal samples were collected from 2277 SARS-CoV-2-positive patients. Two multiplex approaches were used to detect and sequence SARS-CoV-2, influenza A/B viruses, and other seasonal respiratory viruses: multiplex real-time polymerase chain reaction (PCR) and multiplex next-generation sequencing. Coinfections of SARS-CoV-2 with other respiratory viruses were detected in 164 (7.2%) patients. The most common co-infecting virus was respiratory syncytial virus (RSV) (38 cases, 1.7%), followed by bocavirus (BoV) (1.2%) and rhinovirus (RV) (1.1%). Patients ≤ 16 years of age had the highest rate (15%) of mixed infections. Whole-genome sequencing produced 19 complete genomes of seasonal respiratory viral co-pathogens, which were subjected to phylogenetic and amino acid analyses. The detected influenza viruses were classified into the genetic groups 6B.1A.5a.2a and 6B.1A.5a.2a.1 for A(H1N1)pdm09, 3C.2a1b.2a.2a.1 and 3C.2a.2b for A(H3N2), and V1A.3a.2 for the B/Victoria lineage. The RSV-B sequences belonged to the genetic group GB5.0.5a, with HAdV-C belonging to type 1, BoV to genotype VP1, and PIV3 to lineage 1a(i). Multiple amino acid substitutions were identified, including at the antibody-binding sites. This study provides insights into respiratory viral coinfections involving SARS-CoV-2 and reinforces the importance of genetic characterization of co-pathogens in the development of therapeutic and preventive strategies.
ANCA-Positive Small-Vessel Vasculitis Following SARS-CoV-2 Vaccination—A Systematic Review
Authors: Łysak Kinga , Walulik Agata , Błaszkiewicz Michał , Gomułka Krzysztof
Published: June 2024

As vaccinations against the SARS-CoV-2 virus have become a crucial tool in controlling the spread of the disease, reports of rare health complications have emerged, including new-onset antineutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis (AAV). We systematically reviewed new-onset AAV following COVID-19 vaccination case reports and case series published in three databases before January 2024 following PRISMA guidelines to understand the characteristics of possible causal relationships or coincidences. In total, 404 articles were screened respectively by title, abstracts, and full-texts. Thirty-four papers fulfilled the inclusion criteria and have been analyzed, covering 44 patients with new-onset AAV after COVID-19 vaccination with no prior history of COVID-19 infection. Data regarding patients’ metrics, comorbidities, vaccination characteristics, symptoms, diagnostics, treatment, and outcomes were investigated and summarized. The cohort consisted predominantly of females. AAV diagnosis was confirmed via biopsy, with renal dysfunction as a prevailing manifestation. In most cases, the first symptoms of AAV developed after the second dose; moreover, Pfizer-BioNTech was the most frequently administered vaccine among the analyzed cohort. Primary treatment involved glucocorticoid therapy, with a mostly favourable response. This systematic review aims to raise awareness among clinicians in the field regarding this rare but possible complication, to promote the prompt recognition and diagnosis of de novo ANCA-positive small-vessel vasculitis in timely association with SARS-CoV-2 vaccination.
COVID-19 Vaccination in Pregnancy: Pilot Study of Plasma MicroRNAs Associated with Inflammatory Cytokines after COVID-19 mRNA Vaccination
Authors: Shen Ching-Ju , Lin Yen-Pin , Chen Wei-Chun , Cheng Mei-Hsiu , Hong Jun-Jie , Hu Shu-Yu , Shen Ching-Fen , Cheng Chao-Min
Published: June 2024

Background: The impact of mRNA COVID-19 vaccines on the immunological profiles of pregnant women remains a crucial area of study. This research aims to explore the specific immunological changes triggered by these vaccines in this demographic. Methods: In a focused investigation, we examined the effects of mRNA COVID-19 vaccination on microRNA expression in pregnant women. Key microRNAs, including miR-451a, miR-23a-3p, and miR-21-5p, were analyzed for expression changes post-vaccination. Additionally, we assessed variations in S1RBD IgG levels and specific cytokines to gauge the broader immunological response. Results: Post-vaccination, significant expression shifts in the targeted microRNAs were observed. Alongside these changes, we noted alterations in S1RBD IgG and various cytokines, indicating an adapted inflammatory response. Notably, these immunological markers displayed no direct correlation with S1RBD IgG concentrations, suggesting a complex interaction between the vaccine and the immune system in pregnant women. Conclusions: Our pilot study provides valuable insights into the nuanced effects of the mRNA COVID-19 vaccine on immune dynamics in pregnant women, particularly emphasizing the role of microRNAs. The findings illuminate the intricate interplay between vaccines, microRNAs, and immune responses, enhancing our understanding of these relationships in the context of pregnancy. This research contributes significantly to the growing body of knowledge regarding mRNA COVID-19 vaccines and their specific impact on maternal immunology, offering a foundation for further studies in this vital area.
A Narrative Review on the Promising Potential of Graphene in Vaccine Design: Evaluating the Benefits and Drawbacks of Carbon Nanoplates in Nanovaccine Production
Authors: Zare-Zardini Hadi , Saberian Elham , Jenča Andrej , Jenča Andrej , Petrášová Adriána , Jenčová Janka
Published: June 2024

Graphene, a two-dimensional material consisting of a single layer of carbon atoms arranged in a honeycomb lattice, has shown great potential in various fields, including biomedicine. When it comes to vaccine development, graphene can offer several advantages due to its unique properties. Potential applications of graphene in vaccine development include improved vaccine delivery, adjuvant properties, improved vaccine stability, improved immune response, and biosensing capabilities. Although graphene offers many potential benefits in vaccine development, there are also some drawbacks and challenges associated with its use. Although graphene shows promising potential for vaccine development, overcoming the challenges and limitations associated with its use is critical to realizing its full potential in the field of immunization. Further research and development efforts are needed to overcome these drawbacks and take advantage of graphene for improved vaccine formulations. In this review, we focus on the advantages and disadvantages of graphene for vaccine development.
Advancing the Understanding of Complex Piezometric Information: A Methodological Approach Integrating Long-Term Piezometry, Surface Nuclear Magnetic Resonance, and Fracture Analysis Using Insights from the “Calcaires du Barrois” Series, France
Authors: Bertrand Mathieu , Bertrand Catherine , Mazzilli Naomi , Gigleux Sylvain , Denimal Sophie , Valois Rémi , Girod Lise-Marie , Cinkus Guillaume , Busquet Valentine , Chalikakis Konstantinos
Published: June 2024

This study aims to analyze spatio-temporal piezometric data and integrate them with geological, geotechnical, and geophysical data to enhance their interpretation. The research focuses on a site located in the Meuse and Haute-Marne departments of France, which has been under investigation since 1994 as part of the surface facilities characterization for the Meuse-Haute-Marne underground laboratory and the CIGEO (Centre Industriel de stockage Géologique) Andra project. These investigations span different spatial and temporal scales. We observed the contribution of water masses associated with external forcing and identified two types of aquifer responses: a rapid response to rainfall events when fractures are well-connected, and minor reactivity at the matrix level. Additionally, we demonstrated that the matrix compartment can be finely characterized through a combined interpretation of piezometric response analysis, fracture analysis, and surface nuclear magnetic resonance (SNMR) soundings. The methodology developed in this project offers an improved understanding of karst piezometry and/or unsaturated zone extension, which is essential for comprehend ding flow dynamics and better constraining the functioning of karst aquifers. Furthermore, this site serves as an ideal workshop for studying flow in fractured media, providing valuable insights into hydrodynamic behavior in complex subsurface environments.
Effect of Coal Mining Subsidence on Soil Enzyme Activity in Mining Areas with High Underground Water Levels
Authors: Xu Ruiping , Li Junying , Li Xinju , Zhang Jinning , Song Wen
Published: June 2024

In order to investigate the changes in soil enzyme activity and their influencing factors in coal mining subsidence areas with high underground water levels, in this study, we collected soil samples at different depths (SL: 0–20 cm; ML: 20–40 cm; DL: 40–60 cm) in a deep coal seam subsidence area (T1), a shallow coal seam subsidence area (T2), and control non-subsidence areas (W1 and W2) in eastern China. Soil physicochemical properties and enzyme activities were determined, and the mechanism of the latter’s response to coal mining subsidence was investigated based on correlation analysis, redundancy analysis, and structural equation modeling. The results show the following: (1) In the coal mining subsidence areas, the soil pH value (pH), soil available nitrogen (AN), available phosphorus (AP), available potassium (AK), and soil organic matter (SOM) contents were lower than those in the non-subsidence areas, while the soil water content (SWC) and bulk density (BD) were higher than those in the non-subsidence areas and increased with depth. (2) The activities of soil urease (URE), sucrase (SUC), alkaline phosphatase (ALP), and catalase (CAT) gradually decreased with depth and were all lower than those in the non-subsidence areas; the largest decreases with respect to the latter were 24.33%, 18.73%, 38.89%, and 5.88%, respectively. (3) The soil nutrient environment had a highly significant and direct positive effect on enzyme activity, with AN, AP, and SOM contents having the greatest impact. (4) Soil BD had a highly significant and direct negative effect and an indirect negative effect (by affecting nutrients) on enzyme activity. The results of this study on the effects of soil physicochemical properties on enzyme activity provide a basis for the ecological restoration of mines.
SYNERGY OF SPIRITUALITY AND CREATIVITY IN STUDENT CULTURAL AND ART PROJECTS
Authors: Lymarenko L.
Published: June 2024

The article substantiates the question of the relationship between spirituality and creativity in the internal environment of the acquirer's personality as an important factor in the conditions of the educational process within the framework of the creation of a cultural and artistic project. Attention is focused on highlighting the cultural component of student projects through: the production of synergy, which is defined in the unity of national traditions and spiritual universal values shared by the acquirers; the truthfulness of the transmission of sensitive events and the honesty of the Ukrainian media space during the war; the author's innovative and synergistic approach to the creation of a Ukrainian cultural product. The author proved the fact that in the process of creating projects within the scope of mastering the long-term certificate program "Organisation and direction of cultural and artistic projects", the level of spirituality of each student of higher education is also reflected in his artistic creativity: there is interosculation, interaction – synergy. Such a relationship is of great importance for ensuring the successful implementation of the acquirer in the conditions of the external environment – the educational process in the field of cultural practice. This interaction logically forms the basis for further types of targeted artistic and creative activity, which leads to the emergence of new combinations of them in projects through the prism of spirituality. Scientific research has proven that: the synergy of spirituality and creativity, which arises due to the relationship between these phenomena in the inner space of the individual, plays a key role in the creation of cultural and artistic projects-video content; the synergistic action of the acquirers is effectively aimed at the interaction of spiritual values, moral principles and personal creative potential; the acquirer's spirituality as his inner moral essence (orientation towards love, goodness, beauty and truth) in combination with creativity (purposeful, conscious artistic activity) create a synergy that leads to the creative generation of new cultural and artistic projects; creativity as a complex, dynamic, but consciously organisational and original process of embodying the creative ideas of an individual, reveals the self-sufficiency of the acquirer as an artist, who is the creator of a new cultural and artistic product, distinguished by its uniqueness; the total effect of the synergy of spirituality and creativity, under the conditions of combination and interaction of several project participants, increases the level of effectiveness of joint activities of master's students.
eutanasia en Colombia y Ecuador. Derecho a una muerte asistida
Authors: Estrella Saltos Ronny Michael
Published: June 2024

En el contexto actual, la discusión sobre la eutanasia y el derecho a una muerte digna ha cobrado gran relevancia en Latinoamérica. El objetivo del estudio fue describir la eutanasia en Colombia y Ecuador. Derecho a una muerte asistida. La metodología es cualitativa, con paradigma interpretativo y aplicación del método hermenéutico, corresponde a una investigación de análisis jurídico, la técnica fue revisión documental de la jurisprudencia y la legislación en Colombia y Ecuador. La recogida de datos fue la entrevista y el instrumento fue la matriz de análisis. Los resultados exponen reflexión sobre la muerte digna, sentido de la vida y el papel de la autonomía individual. Como conclusión se tiene que la Corte Constitucional colombiana realizó una valoración de los derechos fundamentales dignidad humana, autonomía, libertad, consentimiento informado y el derecho a la vida. La eutanasia en Ecuador era un tema envuelto en el vacío legal. Sin embargo, en un avance significativo marca un hito en la historia del país.
RISIKO FRAKTUR PADA PARUH BAYA DAN LANSIA
Authors: Salsabella Edellweisse Silvia , Harun Hasniatisari , Pebrianti Sandra , Pramukti Iqbal
Published: June 2024

Paruh baya dan lansia berisiko mengalami fraktur osteoporosis berdasarkan peningkatan angka kejadian fraktur seiring bertambahnya usia, perubahan kebiasaan gaya hidup, terapi farmakologis, dan kondisi medis yang dapat meningkatkan risiko fraktur osteoporosis. Angka kejadian fraktur osteoporosis diperkirakan terus meningkat di masa yang akan datang. Berdasarkan fenomena tersebut, diperlukan upaya preventif dengan deteksi dini skrining risiko fraktur guna mengurangi dan mencegah fraktur osteoporosis pada paruh baya dan lansia di masa yang akan datang. Penelitian ini bertujuan untuk mengetahui risiko fraktur pada paruh baya dan lansia. Metode penelitian menggunakan deskriptif kuantitatif. Sampel penelitian berjumlah 120 responden  dengan teknik pengambilan sampel menggunakan consecutive sampling. Instrumen yang digunakan adalah FRAX® Tool tanpa BMD terdiri dari 11 item pertanyaan yang telah dinilai valid dan reliabel menjadi alat skrining risiko fraktur. Hasil penelitian ini menunjukkan bahwa seluruh paruh baya memiliki risiko fraktur osteoporosis mayor rendah (100%) dan risiko fraktur pinggul rendah (100%). Mayoritas lansia memiliki risiko fraktur osteoporosis mayor rendah (96,7%) dan risiko fraktur pinggul rendah (83,3%). Penelitian ini juga menunjukkan bahwa risiko fraktur osteoporosis mayor dan fraktur pinggul lebih tinggi pada lansia dibanding paruh baya. Upaya preventif perlu diimbangi dengan mengendalikan berbagai faktor risiko fraktur osteoporosis yang dapat dilakukan dengan menjalani pola hidup yang sehat, seperti melakukan aktivitas fisik teratur, peningkatan asupan nutrisi kalsium dan vitamin D, terpapar sinar matahari yang cukup, dan mengurangi kebiasaan merokok.
THE FEATURES OF MEDICAL INSTITUTIONS PLACEMENT IN THE SPATIAL STRUCTURE OF KAZAN
Authors: Zakieva L.
Published: June 2024

The work is devoted to a comprehensive cartographic analysis of the location of medical institutions in the structure of the city of Kazan. The provision of the city's territory with medical institutions is determined and the development of a digital model that displays the location of existing medical institutions is demonstrated. The possibility of automated modeling in geographic information systems of designed objects in order to optimally place these objects in the planning structure of the city is provided. The results of the study form the basis of a digital model for the location of medical institutions in Kazan. In addition to healthcare facilities, the digital model displays pedestrian graphs built according to the parameter of 20-minute pedestrian accessibility, outpatient clinics and transport graphs displaying 30-minute transport accessibility of multidisciplinary hospitals, emergency rooms, maternity hospitals and dispensaries. An analysis of the provision of the population of Kazan with medical institutions was carried out in accordance with the current standards of urban planning in the field of healthcare; territories not covered by the radius of accessibility of existing medical organizations were identified. To optimize the territorial location of medical institutions, it was proposed to introduce a cluster-network model, which was tested in Kazan. The results of the work contribute to increasing the efficiency of the healthcare system, its modernization and transfer to a modern level of service to the population. The digital model is the basis for forming an overall picture that allows planning, forecasting and making the most optimal decisions regarding the spatial placement of medical institutions.
L’habitat du premier Moyen Âge dans le massif du Jura (Ve-XIIe siècles)
Authors: Billoin David
Published: June 2024

Cet article se propose de présenter, de manière synthétique, les différentes formes d’habitat de l’Arc jurassien en privilégiant les données récemment acquises, et pour la plupart inédites. Ce panorama témoigne de l’extrême diversité des formes de l’occupation, par des établissements construits en bois ou en pierre, en plaine ou sur des hauteurs, de type agro-pastoral ou de statut plus élitaire. Certaines activités économiques, autour du fer et du sel, sont également évoquées afin d’aborder une lecture sociale de ces établissements et d’esquisser les traits parfois originaux d’un territoire formant une entité géographique et culturelle relativement homogène.
Les Aouzerals (La Malène, Lozère) durant le premier Moyen Âge : premiers éléments de réflexion sur les activités et la vie quotidienne
Authors: Breichner Hélène , Pagès Gaspard , Peloux Fernand
Published: June 2024

Los estudios paleo-metalúrgicos y arqueozoológicos realizados en el mobiliario del yacimiento de Aouzerals (La Malène, Lozère) permiten documentar desde un nuevo ángulo los hábitats dispersos de Caussenard de la Alta Edad Media. Los agricultores estaban visiblemente bien alimentados y muestran una cierta técnica para la explotación de todos los recursos a su disposición, especialmente de los minerales de hierro.
Les composantes de l’habitat rural du haut Moyen Âge et les dynamiques de peuplement en Poitou-Charentes : l’exemple des Sablons à Luxé (Charente)
Authors: Maury Marie , Crépeau Natacha , Vallet Sophie
Published: June 2024

The preventive dig conducted in 2011 by Archéosphère on the site of Sablons in Luxé (Charente) presented the opportunity of uncovering the margins of a settlement from the early Middle Ages as well as its necropolis. This settlement, organised into farming units in its northern section, pays witness to the complexity of components in a domestic sphere. It seems to have been mainly used between the 5th and 10th centuries. The different structures, characterised by their contemporaneity and/ or their succession, can be compared to those observed in contemporary sites in the Poitou-Charentes. The community’s zone of graves used by this settlement is also a non-negligible source of information in understanding the population dynamics in the region. Indeed, the study of furniture and human remains at Sablons and in medieval necropolises nearby has provided much data that gives insights to the contacts and exchanges between populations.
L'évaluation archéologique du village d’Esvres et de son territoire (Indre-et-Loire). Un bilan d’étape pour le premier Moyen Âge
Authors: Chimier Jean-Philippe , Bouillon Jérôme , Cherdo François , Jaffrot Etienne , Joly Stéphane , Fouillet N. , Pichon Isabelle , Pouyet Thomas , Simard Mélanie , Yvernault Françoise
Published: June 2024

Le programme de recherche Evena porte sur l’évaluation du village d’Esvres-sur-Indre et de son territoire rural. Il a pour objectif l’étude du peuplement dans la longue durée. Le site est documenté par les archives et l’archéologie. Une nécropole à sarcophages constitue la principale occupation reconnue dans le village, l’habitat médiéval n’a pas été mis au jour. Plusieurs établissements ruraux ont été fouillés ou reconnus par prospection. Deux pôles ont retenu notre attention : le secteur de Forges et le plateau de Besnoëls, situés aux marges du territoire communal.
Stockage et mouture au Bronze final II b à Guignicourt "L’Homme Mort" (Aisne)
Authors: Hénon Bénédicte , Monchablon Cécile , Le Guen Pascal
Published: June 2024

Bei einer Präventivgrabung wurde in Guignicourt „L’Homme Mort“ (Departement Aisne) eine kleine spätbronzezeitliche Lagerstruktur freigelegt. Sie zeichnet sich durch die Menge und Qualität der Mahlgeräte aus, die dort gefunden wurden. In der Tat zeugen die exogenen Mahlgeräte (Arkose und Basalt aus den Ardennen bzw. der Eifel) von den Tauschbeziehungen mit dem Kontinent und legen die Hypothese der Existenz spezialisierter „Produktionsstätten“ nahe.
Clinical Features of Moving Teeth
Authors: Новак Н.В. , Зиновенко О.Г. , Старовойтова В.С.
Published: June 2024

Введение. Патологическая подвижность зуба при острой и хронической травмах может быть причиной разрыва сосудисто-нервного пучка и некроза пульпы, что требует своевременной диагностики и лечения. Цель исследования. Изучить клинические особенности подвижных зубов перед шинированием – степень подвижности зубов, электровозбудимость пульпы, температурные пробы. Материалы и методы. Клинические особенности подвижных зубов изучены на группе из 222 пациентов с острой и хронической травмами зуба. После проведения общих методов диагностики изучали степень подвижности зубов, данные электро-одонтометрии и температурные пробы. Результаты. Исследования клинических особенностей подвижных зубов показали, что при острой травме при локализации линии перелома корня в апикальной части корональный фрагмент зуба был неподвижен и в иммобилизации не нуждался. При переломе корня, который локализуется в средней и коронарной третях зуба, а также при вывихе и хронической окклюзионной травме во всех случаях требовалась иммобилизация. При усредненных диагностических значениях электровозбудимости пульпы и температурной пробы постоянных зубов после острой травмы была отмечена существенная разница показателей в зависимости от времени, прошедшего после травмы. Электровозбудимость зубов с хронической травмой была повышена, выявлены зубы с некрозом пульпы и эндопериодонтитом. Вывод. Изучение клинических особенностей подвижных зубов способствует ранней диагностике воспалительных и некротических изменений в пульпе и тканях периодонта.

Introduction. Pathologic tooth mobility in acute and chronic trauma may be the cause of rupture of the neurovascular bundle and pulp necrosis, which requires timely diagnosis and treatment. Purpose of the study. To study the clinical features of mobile teeth before splinting – the degree of tooth mobility, pulp electrical excitability, temperature tests. Materials and methods. Clinical features of mobile teeth were studied on a group of 222 patients with acute and chronic dental traumas. After general diagnostic methods the degree of tooth mobility, electroodontometry and temperature tests were studied. Results. The study of clinical features of mobile teeth showed that in acute trauma with localization of the root fracture line in the apical part, the coronal fragment of the tooth was immobile and did not need immobilization. In root fracture localized in the middle and coronal thirds of the tooth, as well as in dislocation and chronic occlusal trauma, immobilization was required in all cases. When averaging diagnostic values of pulp electroexcitability and temperature test of permanent teeth after acute trauma, there was a significant difference in the values depending on the time elapsed after the trauma. The values of electroexcitability of teeth with chronic trauma were increased, teeth with pulp necrosis and endoperiodontitis were detected. Conclusion. The study of clinical features of mobile teeth contributes to the early diagnosis of inflammatory and necrotic changes in the pulp and periodontal tissues.
APTITUD COMBINATORIA Y HETEROSIS EN VARIEDADES DE GERBERA (Gerbera × hybrida)
Authors: Rivera-Colín Azucena , Mejía-Carranza Jaime , Vázquez-García Luis M. , Urbina-Sánchez Elizabeth , Ramírez-Gerardo Marithza G.
Published: June 2024

Los cultivos que cuentan con un número considerable de variedades cultivadas, como la gerbera (Gerbera × hybrida), pueden ser evaluados mediante experimentos de cruzas dialélicas para la formación de nuevos híbridos. El objetivo de la presente investigación fue estimar la aptitud combinatoria general (ACG) de seis variedades de gerbera y la aptitud combinatoria específica (ACE) de sus cruzas dialélicas, así como la heterosis en componentes de rendimiento y calidad de flores. Se empleó el método 1 de progenitores y sus cruzas F1 directas y recíprocas con el modelo II de efectos aleatorios de Griffing. La evaluación se realizó bajo un diseño experimental de bloques completos al azar con cuatro repeticiones. El análisis estadístico detectó diferencias significativas (P ≤ 0.01) dentro y entre progenitores y cruzas, así como en las interacciones, lo que evidenció amplia variabilidad entre progenitores y efectos maternos significativos por herencia citoplásmica. Los mayores efectos de ACG (P ≤ 0.01) para rendimiento de tallos florales lo tuvieron los progenitores IGL, MG2 y FAS, mientras que los mayores efectos de ACE los mostraron las cruzas FAS × JES, ALC × IGL y DIN × IGL. Se encontraron efectos positivos de heterosis para rendimiento en las cruzas FAS × IGL, JES × IGL, ALC × IGL, DIN × IGL, MG2 × IGL y FAS × MG2. Los resultados sugieren que Igloo y Fascination pueden ser utilizados como progenitores superiores en programas de cruzamiento para desarrollo de nuevas variedades de gerbera. Los valores altamente significativos de ACG para rendimiento de flor indican la importancia relativa de la acción génica aditiva sobre los efectos no aditivos.
H-389 O, HÍBRIDO TRILINEAL DE MAÍZ DE GRANO BLANCO OLEOSO ADAPTADO A REGIONES SUBTROPICALES DE MÉXICO
Authors: Preciado-Ortiz Ricardo E. , Terrón-Ibarra Arturo D. , Vázquez-Carrillo Ma. Gricelda , Gómez-Montiel Noel O. , Briones-Reyes Dolores , Peña-Ramos Alfonso
Published: June 2024

En las regiones subtropicales de México, el mejoramiento genético del maíz (Zea mays L.) se ha enfocado tradicionalmente hacia la obtención de híbridos de alto rendimiento; sin embargo, las necesidades nutrimentales e industriales han reorientado los programas de mejoramiento para incluir aspectos de calidad nutricional e industrial del grano (Ortiz-Monasterio et al., 2007), donde el maíz con alto contenido de aceite (ACA) es de gran importancia para las industrias aceitera y de alimentos balanceados. Un maíz ACA contiene más del 6 % de aceite, en comparación con el maíz normal que tiene entre 2.0 y 5.0 %. El maíz ACA tiene valor nutricional adicional por su energía metabolizable, con un efecto significativo en raciones para animales, y puede sustituir grasas, harina de soya o aminoácidos esenciales sintéticos, lo que mejora la dieta (Alexander, 1988; Lambert, 2000). Una serie de estudios revisados por Lambert (2000) con cerdos, aves, ovejas y vacas lecheras, alimentados con raciones de maíz ACA mostraron en ellos mayor crecimiento, eficiencia alimenticia y calidad de sus productos.
PRIMER REPORTE DE Colletotrichum coccodes EN FRUTOS DE TOMATE (Solanum lycopersicum) EN MÉXICO
Authors: Nieto-Angel Daniel , Almaraz-Sánchez Alejandra , Ayala-Escobar Victoria , Orozco-Santos Mario , Lara-Viveros Francisco M.
Published: June 2024

La antracnosis, ocasionada por Colletotrichum coccodes, afecta solanáceas y cucurbitáceas. En México este patógeno se ha reportado en el cultivo de papa (Solanum tuberosum L.), pero no en tomate (Solanum lycopersicum). En el año 2015 se observó la presencia del síntoma de lesiones hundidas con 7 % de incidencia en frutos de tomate de muestras en campo abierto del estado de Morelos, México. El objetivo del presente estudio fue identificar al agente causal del síntoma de antracnosis en el fruto mediante características morfológicas y moleculares. El material colectado se desinfestó y sembró en medio de cultivo PDA (papa-dextrosaagar) y agar-jugo V8, a partir de lesiones hundidas en las cuales se observó formación de esclerocios, setas, conidios cilíndricos, hialinos, sin septos, de 3.16 a 4.16 μm de ancho y de 12.5 a 17.2 μm de largo con apresorios lobulados. En la caracterización molecular, las secuencias obtenidas con los inciadores ITS5/ITS4 tuvieron una similitud del 100 % con Collectotrichum coccodes. Las pruebas de patogenicidad se realizaron en frutos sanos con o sin herida y se evaluó el tamaño de la lesión cada 48 h. Los síntomas iniciales aparecieron a las 72 h y a los 8 d presentaron lesiones desde 0.5 hasta 3.25 cm de diámetro. La prueba de Tukey detectó diferencias significativas entre métodos de inoculación. Este es el primer reporte de Collectotrichum coccodes que afecta frutos de tomate en México.