bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of microRNA-224-3p and microRNA-155-5p expressions with plasma long pentraxin 3 concentration and coronary microvascular obstruction following primary angioplasty for acute ST-segment elevation myocardial infarction
Authors: Dharma Surya , Dakota Iwan , Wijaya Shoma , Ekawati Elok , Sukmawan Renan , Siswanto Bambang Budi
Published: October 2020

Objective

Pro-inflammatory stimuli induce a variety set of microRNAs (miRs) expression that regulate long pentraxin-3 (PTX3) protein, which associates with a procoagulant state in the endothelial cells. We evaluated, for the first time in human, the association of miR-224-3p and miR-155-5p expressions with plasma PTX3 concentration and coronary microvascular obstruction (MVO) in patients with acute ST-segment elevation myocardial infarction (STEMI) with symptom onset ≤ 12 h and treated by primary angioplasty. Blood samples for miRs and PTX3 measurement were drawn at emergency department presentation, and were measured by TaqMan real-time PCR and human ELISA kit, respectively.

Results

Of the 217 patients (median age: 54 years, male: 88%), 130 (60%) had angiographic MVO. Spearman analysis showed no correlation between miR-224-3p and miR-155-5p expressions with plasma PTX3 concentration. After adjustment with sex, age, diabetes mellitus, and plasma PTX3 concentration, miR-224-3p ≥ median group was associated with angiographic MVO (odds ratio, 2.60; 95% confidence interval, 1.24 to 5.44, p = 0.01). This study suggests that miR-224-3p and miR-155-5p expressions did not correlate with plasma PTX3 concentration. However, miR-224-3p expression associates with angiographic MVO following primary angioplasty for STEMI. Future studies are needed to identify the specific gene/protein related with miR-224-3p expression in MVO.
Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson’s disease: a longitudinal study
Authors: Ge Jingjie , Wang Min , Lin Wei , Wu Ping , Guan Yihui , Zhang Huiwei , Huang Zhemin , Yang Likun , Zuo Chuantao , Jiang Jiehui , Rominger Axel , Shi Kuangyu
Published: October 2020

Background

With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson’s disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome.
This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with 18F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD.

Methods

Age-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent 18F-FDG PET scans. The DBS patients were followed longitudinally to investigate the alternations of the PD-related metabolic covariance pattern (PDRP) expressions.

Results

The PDRP expression was abnormally elevated in PD patients compared with HCs (P < 0.001). For DBS patients, a significant decrease in the Unified Parkinson’s Disease Rating Scale (UPDRS, P = 0.001) and PDRP expression (P = 0.004) was observed 3 months after STN DBS treatment, while a rollback was observed in both UPDRS and PDRP expressions (both P < 0.01) 12 months after treatment. The changes in PDRP expression mediated by STN DBS were generally in line with UPDRS improvement. The graphical network analysis shows increased connections at 3 months and a return at 12 months confirmed by small-worldness coefficient.

Conclusions

The preliminary results demonstrate the potential of metabolic network expression as complimentary objective biomarker for the assessment and monitoring of STN DBS treatment in PD patients.

Clinical Trial Registration ChiCTR-DOC-16008645. http://www.chictr.org.cn/showproj.aspx?proj=13865.
Fractional calculus and integral transforms of the product of a general class of polynomial and incomplete Fox–Wright functions
Authors: Jangid K. , Parmar R. K. , Agarwal R. , Purohit Sunil D.
Published: October 2020

Motivated by a recent study on certain families of the incompleteH-functions (Srivastava et al. in Russ. J. Math. Phys. 25(1):116–138, 2018), we aim to investigate and develop several interesting properties related to product of a more general polynomial class together with incomplete Fox–Wright hypergeometric functions${}_{p}\Psi _{q}^{(\gamma )}(\mathfrak{t})$Ψq(γ)p(t)and${}_{p}\Psi _{q}^{(\Gamma )}(\mathfrak{t})$Ψq(Γ)p(t)including Marichev–Saigo–Maeda (M–S–M) fractional integral and differential operators, which contain Saigo hypergeometric, Riemann–Liouville, and Erdélyi–Kober fractional operators as particular cases regarding different parameter selection. Furthermore, we derive several integral transforms such as Jacobi, Gegenbauer (or ultraspherical), Legendre, Laplace, Mellin, Hankel, and Euler’s beta transforms.
Prevalence, incidence, and trends of childhood overweight/obesity in Sub-Saharan Africa: a systematic scoping review
Authors: Danquah Frederick Inkum , Ansu-Mensah Monica , Bawontuo Vitalis , Yeboah Matilda , Kuupiel Desmond
Published: October 2020

Background

The growing burden of non-communicable diseases (NDC), particularly in low-and middle-income countries, poses a significant threat to global health. Obesity and overweight constitute major risk factors of NCDs such as heart diseases, diabetes, and kidney disease, and as a result, contribute significantly to the development of chronic morbidities, reduced quality of life, and increased risk of premature death. This study described evidence on the prevalence, incidence, and trends of childhood overweight and obesity in sub-Sahara Africa (SSA).

Methods

We conducted a systematic scoping review employing the Arksey and O’Malley framework, Levac et al. recommendations, and the Joanna Briggs Institute guidelines. To obtain relevant published articles for this review, we performed a comprehensive keywords search in PubMed, Google Scholar, Web of Science, and CINAHL via EBSCOhost platform for studies published between 2009 and June 2019. Guided by the eligibility criteria, title and abstracts, as well as the full-text articles were independently screened in parallel by two investigators. All relevant data were independently extracted by two investigators using a piloted form designed in Microsoft and thematic analysis conducted.

Results

Of the 81 included studies obtained from 250,148 potentially eligible articles, the majority (25) conducted in South Africa followed by 18 in Nigeria. Six studies were conducted in Ethiopia (6), Tanzania (5), Kenya (4), Cameroon (4), Ghana (3), Uganda (2), Mozambique (2), and Sudan (2). One study each was conducted in Botswana, Gambia, Lesotho, Mauritius, Seychelles, Togo, and Zimbabwe. The remaining three articles were multi-country studies. Most (81.5%) of the included studies were cross-sectional surveys and the majority (79) focused on both male and female participants. The majority (80/81) of the included studies reported on the prevalence of childhood overweight/obesity, 8 on the trends of childhood overweight/obesity, and one presented evidence on the incidence of childhood overweight and obesity in SSA.

Conclusion

This review demonstrates limited studies on childhood overweight/obesity in most SSA countries although the included studies suggest an increasing burden. Considering the consequences of childhood obesity, there is a need for more primary researches to inform policies decision and implementation to halt the rise of childhood obesity/overweight in SSA.
The Kalmag model as a candidate for IGRF-13
Authors: Baerenzung Julien , Holschneider Matthias , Wicht Johannes , Lesur Vincent , Sanchez Sabrina
Published: October 2020

We present a new model of the geomagnetic field spanning the last 20 years and called Kalmag. Deriving from the assimilation of CHAMP and Swarm vector field measurements, it separates the different contributions to the observable field through parameterized prior covariance matrices. To make the inverse problem numerically feasible, it has been sequentialized in time through the combination of a Kalman filter and a smoothing algorithm. The model provides reliable estimates of past, present and future mean fields and associated uncertainties. The version presented here is an update of our IGRF candidates; the amount of assimilated data has been doubled and the considered time window has been extended from [2000.5, 2019.74] to [2000.5, 2020.33].
Mutant Isocitrate Dehydrogenase 1 Inhibitor Ivosidenib in Combination With Azacitidine for Newly Diagnosed Acute Myeloid Leukemia
Authors: DiNardo Courtney D. , Stein Anthony S. , Stein Eytan M. , Fathi Amir T. , Frankfurt Olga , Schuh Andre C. , Döhner Hartmut , Martinelli Giovanni , Patel Prapti A. , Raffoux Emmanuel , Tan Peter , Zeidan Amer M. , de Botton Stéphane , Kantarjian Hagop M. , Stone Richard M. , Frattini Mark G. , Lersch Frederik , Gong Jing , Gianolio Diego A. , Zhang Vickie , Franovic Aleksandra , Fan Bin , Goldwasser Meredith , Daigle Scott , Choe Sung , Wu Bin , Winkler Thomas , Vyas Paresh
Published: October 2020

PURPOSE

Ivosidenib is an oral inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme, approved for treatment of IDH1-mutant (m IDH1) acute myeloid leukemia (AML). Preclinical work suggested that addition of azacitidine to ivosidenib enhances mIDH1 inhibition–related differentiation and apoptosis.

PATIENTS AND METHODS

This was an open-label, multicenter, phase Ib trial comprising dose-finding and expansion stages to evaluate safety and efficacy of combining oral ivosidenib 500 mg once daily continuously with subcutaneous azacitidine 75 mg/m2 on days 1-7 in 28-day cycles in patients with newly diagnosed m IDH1 AML ineligible for intensive induction chemotherapy (ClinicalTrials.gov identifier: NCT02677922 ).

RESULTS

Twenty-three patients received ivosidenib plus azacitidine (median age, 76 years; range, 61-88 years). Treatment-related grade ≥ 3 adverse events occurring in > 10% of patients were neutropenia (22%), anemia (13%), thrombocytopenia (13%), and electrocardiogram QT prolongation (13%). Adverse events of special interest included all-grade IDH differentiation syndrome (17%), all-grade electrocardiogram QT prolongation (26%), and grade ≥ 3 leukocytosis (9%). Median treatment duration was 15.1 months (range, 0.3-32.2 months); 10 patients remained on treatment as of February 19, 2019. The overall response rate was 78.3% (18/23 patients; 95% CI, 56.3% to 92.5%), and the complete remission rate was 60.9% (14/23 patients; 95% CI, 38.5% to 80.3%). With median follow-up of 16 months, median duration of response in responders had not been reached. The 12-month survival estimate was 82.0% (95% CI, 58.8% to 92.8%). m IDH1 clearance in bone marrow mononuclear cells by BEAMing (beads, emulsion, amplification, magnetics) digital polymerase chain reaction was seen in 10/14 patients (71.4%) achieving complete remission.

CONCLUSION

Ivosidenib plus azacitidine was well tolerated, with an expected safety profile consistent with monotherapy with each agent. Responses were deep and durable, with most complete responders achieving m IDH1 mutation clearance.
B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study
Authors: Modak Shakeel , Zanzonico Pat , Grkovski Milan , Slotkin Emily K. , Carrasquillo Jorge A. , Lyashchenko Serge K. , Lewis Jason S. , Cheung Irene Y. , Heaton Todd , LaQuaglia Michael P. , Cheung Nai-Kong V. , Pandit-Taskar Neeta
Published: October 2020

PURPOSE

Desmoplastic small round cell tumor (DSRCT), a rare sarcoma of adolescents/young adults primarily involving the peritoneum, has a long-term survival of < 20% despite aggressive multimodality treatment. B7H3 is expressed on DSRCT cell surface, providing a target for antibody-based immunotherapy.

PATIENTS AND METHODS

In this phase I study, we evaluated the safety, pharmacokinetics, and biodistribution of intraperitoneal (IP) radioimmunotherapy (RIT) with the anti-B7H3 murine monoclonal antibody 131I-omburtamab in patients with DSRCT or other B7H3-expressing tumors involving the peritoneum. After thyroid blockade, patients received 131I-omburtamab as a single IP injection at escalated activities from 1.11 to 3.33/GBq/m2. A prior tracer dose of IP 74 MBq124I-omburtamab was used for radioimmuno–positron emission tomography imaging. Each injection was followed by IP saline infusion.

RESULTS

Fifty-two patients (48, three, and one with DSRCT, peritoneal rhabdomyosarcoma, and Ewing sarcoma, respectively) received IP 131I-omburtamab administered on an outpatient basis. Maximum tolerated dose was not reached; there were no dose-limiting toxicities. Major related adverse events were transient: grade 4 neutropenia (n = 2 patients) and thrombocytopenia (n = 1), and grade 1 (10%) and grade 2 (52%) pain lasting < 2 hours related to saline infusion. Hypothyroidism was not observed, and antidrug antibody was elicited in 5%. Mean (± SD) projected peritoneal residence time was 22.4 ± 7.9 hours. Mean projected absorbed doses for 131I-omburtamab based on 124I-omburtamab dosimetry to normal organs were low and well within tolerable limits. More than 80% 131I remained protein bound in blood 66 hours after RIT. On the basis of peritoneal dose and feasibility for outpatient administration, the recommended phase II activity was established at 2.96 GBq/m2. Patients with DSRCT receiving standard whole-abdominal radiotherapy after RIT did not experience unexpected toxicity.

CONCLUSION

IP RIT 131I-omburtamab was well tolerated with minimal toxicities. Radiation exposure to normal organs was low, making combination therapy with other anticancer therapies feasible.
Adrenally Directed Medical Therapies for Cushing Syndrome
Authors: Tritos Nicholas A
Published: October 2020

Context

Endogenous Cushing syndrome (CS) is characterized by excess cortisol secretion, which is driven by tumorous secretion of corticotropin in the majority of patients. Untreated, CS results in substantial morbidity and mortality. Tumor-directed surgery is generally the first-line therapy for CS. However, hypercortisolism may persist or recur postoperatively; in other cases, the underlying tumor may not be resectable or its location may not be known. Yet other patients may be acutely ill and require stabilization before definitive surgery. In all these cases, additional interventions are needed, including adrenally directed medical therapies.

Evidence Acquisition

Electronic literature searches were performed to identify studies pertaining to adrenally acting agents used for CS. Data were abstracted and used to compile this review article.

Evidence Synthesis

Adrenally directed medical therapies inhibit one or several enzymes involved in adrenal steroidogenesis. Several adrenally acting medical therapies for CS are currently available, including ketoconazole, metyrapone, osilodrostat, mitotane, and etomidate. Additional agents are under investigation. Drugs differ with regards to details of their mechanism of action, time course of pharmacologic effect, safety and tolerability, potential for drug-drug interactions, and route of administration. All agents require careful dose titration and patient monitoring to ensure safety and effectiveness, while avoiding hypoadrenalism.

Conclusions

These medications have an important role in the management of CS, particularly among patients with persistent or recurrent hypercortisolism postoperatively or those who cannot undergo tumor-directed surgery. Use of these drugs mandates adequate patient instruction and close monitoring to ensure treatment goals are being met while untoward adverse effects are minimized.
Associations of Hair Cortisol Concentrations with General and Organ Fat Measures in Childhood
Authors: Vehmeijer Florianne O L , Santos Susana , Gaillard Romy , de Rijke Yolanda B , Voortman Trudy , van den Akker Erica L T , Felix Janine F , van Rossum Elisabeth F C , Jaddoe Vincent W V
Published: October 2020

Context

Stress may lead to an adverse body fat distribution from childhood onwards.

Objective

To examine the associations of hair cortisol concentration (HCC) at 6 years with general and organ fat measures, risk of overweight, and nonalcoholic fatty liver disease (NAFLD) at 10 years and to assess whether these were independent of adiposity measures at 6 years.

Design, Setting and participants

HCCs were measured in hair of 6-year-old children (n = 2042) participating in the Generation R Study, a population-based prospective cohort study.

Main Outcome Measures

Body mass index (BMI), fat mass index measured by dual-energy X-ray absorptiometry scan, and visceral fat index, pericardial fat index, liver fat fraction measured by magnetic resonance imaging and risk of overweight and NAFLD were obtained at 10 years.

Results

The associations of higher HCC at 6 years, with higher BMI, fat mass index, and increased risk of overweight at age 10 years are explained by the relationships observed at 6 years. HCCs at 6 years were associated with a higher liver fat fraction (difference 0.11 liver fat fraction standard deviation score; 95% confidence interval [CI] 0.03, 0.18) and a higher risk of NAFLD at 10 years (odds ratio 1.95; 95% CI 1.06, 3.56), independent of fat mass index at 6 years. HCCs were not associated with pericardial or visceral fat indices.

Conclusions

Higher HCCs at 6 years were associated with higher BMI, fat mass index, liver fat fraction, and higher risks of overweight and NAFLD at 10 years. Only the associations for liver fat fraction and NAFLD were independent of fat mass index at 6 years.
Situated Kinmaking and the Population “Problem”
Authors: Dow Katharine , Lamoreaux Janelle
Published: October 2020

Contemporary concern about climate change has been accompanied by a resurgence in questions about what part human numbers play in environmental degradation and species loss. What does population mean, and how is this concept being put to use at a moment when the urgency of climate change seems to elevate the appeal to/of numbers? What role has and should kinship play in understanding “population”? Through a discussion of three recent books—Adele Clarke and Donna Haraway’s edited collection Making Kin Not Population, Michelle Murphy’s The Economization of Life, and Jade Sasser’s On Infertile Ground—this book review essay grapples with the place of human numbers in our understanding of the connections between human reproduction, kinship, and environmental issues. This essay engages most closely with the chapters by Clarke and Haraway in Making Kin, setting out concerns about their turn to (over)population through the analytical insights, historical perspectives, and empirical data of Murphy and Sasser. By putting these three books in dialogue with one another, this essay argues that responsibility for limitations on one’s ability to make kin lies within a heteronormative, White supremacist, capitalist political-economy and its inherent structures of inequality rather than in individual (decision) making.
Are Jokes Going to Cut It?
Authors: Gleeson Jules Joanne
Published: October 2020

Intersex theorist Jules Joanne Gleeson finds Andrea Long Chu's Females: A Concern an indispensable read for those interested in recent struggles around sex and the blossoming of theory that has followed in their wake. While Females makes no pretense at being a comprehensive contribution to gender theory, its brevity and wit seem sure to succeed in causing a stir.
Against Queer Theory
Authors: Keegan Cáel M.
Published: October 2020

The author explores how current disciplinary conditions force trans studies against queer theory: Because queer theory is the institutional context through which trans studies is invited into the university, it is also the containing ideological architecture against which trans studies must articulate itself. Trans studies is therefore pressed “against” queer theory as a discursive surface in a manner that limits it from being able to exit this disciplinary scenario.
Cisgender Commonsense and Philosophy's Transgender Trouble
Authors: Dembroff Robin
Published: October 2020

Analytic philosophy has transgender trouble. In this article, the author explores potential explanations for this trouble, focusing on the notion of “cisgender commonsense” and its place in philosophical methodology.
Empire and Eugenics
Authors: Horbury Ezra , Yao Christine “Xine”
Published: October 2020

This essay offers an overview of trans studies in the United Kingdom in the current climate of transphobia in both academia and the public sphere. This report outlines how trans-exclusionary radical feminist scholars have co-opted the language of victimization and academic freedom following proposed changes to the Gender Recognition Act in 2018. The production of ignorance about trans issues and trans studies is a deliberate project abetted by the UK media even on the left. In response, the authors organized an interdisciplinary trans symposium to affirm trans lives and trans studies for students, scholars, and the wider community. The authors reflect on the successes and failures of the event in light of their institution's past as the origin of eugenics founded by Frances Galton and the broader scope of the legacies of the British empire.
Nothing Until It Is Made Actual; or, Acker versus Growing Up
Authors: Gabriel Kay
Published: October 2020

This essay argues for reading Kathy Acker in terms of what the author calls the “plasticity” of her sentences. These syntactic structures disclose Acker's attempt to expose and negate a bourgeois ideology of adolescence and maturity. The essay pursues this argument through a reading of Acker's novel In Memoriam to Identity, in particular its interest in Rimbaud as both biographical icon and literary precedent. The essay then argues that Acker's concerted literary attack on an ideology of maturity relates to the projects of trans literature at several critical junctures.
Remoras pick where they stick on blue whales
Authors: Flammang Brooke E. , Marras Simone , Anderson Erik J. , Lehmkuhl Oriol , Mukherjee Abhishek , Cade David E. , Beckert Michael , Nadler Jason H. , Houzeaux Guillaume , Vázquez Mariano , Amplo Haley E. , Calambokidis John , Friedlaender Ari S. , Goldbogen Jeremy A.
Published: October 2020

Animal-borne video recordings from blue whales in the open ocean show that remoras preferentially adhere to specific regions on the surface of the whale. Using empirical and computational fluid dynamics analyses, we show that remora attachment was specific to regions of separating flow and wakes caused by surface features on the whale. Adhesion at these locations offers remoras drag reduction of up to 71–84% compared with the freestream. Remoras were observed to move freely along the surface of the whale using skimming and sliding behaviors. Skimming provided drag reduction as high as 50–72% at some locations for some remora sizes, but little to none was available in regions where few to no remoras were observed. Experimental work suggests that the Venturi effect may help remoras stay near the whale while skimming. Understanding the flow environment around a swimming blue whale will inform the placement of biosensor tags to increase attachment time for extended ecological monitoring.
Using triallelic SNPs for determining parentage in North American yak (Bos grunniens) and estimating cattle (B. taurus) introgression
Authors: Kalbfleisch Ted , Petersen Jessica L. , Tait Jr. R. G. , Qiu Jiansheng , Basnayake Veronica , Hackett Peter H. , Heaton Michael P.
Published: October 2020

Background: Genetic testing for pedigree accuracy is critical for managing genetic diversity in North American (NA) yak (Bos grunniens), a population expanded mostly from imported zoological park specimens.  DNA testing also enhances species conservation by identifying recentB. taurusF1 hybrid ancestors (within three generations).  Biallelic single nucleotide polymorphisms (SNPs) can accomplish either task, but increases the marker count and costs necessary to achieve both.  Our aim was to identify novel, multifunctional, triallelic yak SNPs (tySNPs), with each having two alleles for yak parentage testing, and a third allele for identifying recent cattle introgression. 

Methods:  Genome sequences were aligned to the cattle UMD3.1 assembly and SNPs were screened for 1) heterozygosity in a NA and a Chinese yak, 2) a third allele at high frequency in cattle, and 3) flanking sequences conserved in both species.  Subsequently, tySNPs were filtered for unique alignment to the haplotype-resolved F1 yak assembly.  Allele frequencies were estimated in a subset of 87 tySNPs by genotyping 170 NA yak.

Results:  We identified 610 autosomal tySNPs, distributed in 441 clusters with 5 Mb average genome spacing.  The average NA yak minor allele frequency was high (0.296), while average introgressed cattle alleles were low (0.004).  In simulations with tySNPs, 28 were sufficient for globally-unique animal identification (PI=5.81x10-12), 87 were able to exclude 19 random bulls from parentage at the 99% level without using the dam’s genotype (PE=5.3x10-4), and 87 were able to detect F1 hybridization events after three generations of yak backcrosses (1/16thB. taurusgermplasm).

Conclusions:  Identifying animals, determining parentage and detecting recent hybridization events was efficient with as few as 87 tySNPs.  A similar triallelic approach could be used with other bottleneckedBosspecies that hybridize with cattle, such as NA plains bison (B. bison).
PLANEJAMENTO DA OPERAÇÃO DE SISTEMAS INTERLIGADOS COM PREDOMINÂNCIA HIDROELÉTRICA CONSIDERANDO MEDIDAS DE MITIGAÇÃO DE GASES DE EFEITO ESTUFA
Authors: Geber de Melo Albert C. , Justino Thatiana C , Maceira Maria Elvira P. , Cruz Cristiane B.
Published: October 2020

Descreve-se uma abordagem para a incorporação no modelo de planejamento da operação de longo/médio prazo de sistemas hidrotérmicos interligados (NEWAVE) do cálculo de emissões de gases de efeito estufa (GEE), considerando taxas de emissões de GEE por tecnologia, em gCO2eq/kWh, calculadas por meio do conceito de Avaliação do Ciclo de Vida. Também apresenta-se uma estratégia para representar medidas de mitigação dos efeitos das mudanças climáticas no planejamento da operação através da inclusão, no problema resolvido pelo modelo NEWAVE, de restrições que representam limites máximos de emissões de GEE. Estudos de caso com configurações reais do sistema interligado brasileiro são apresentados e discutidos.
Entre dois modos de ser da linguagem – o homem da modernidade de Foucault
Authors: Bogo Fabio Henrique Medeiros
Published: October 2020

Um comentário sobre o desenvolvimento do conceito de homem conforme a articulação elaborada por Michel Foucault em “As Palavras e as Coisas”. Tal conceito encontra suas condições de possibilidade nas transformações de ordem epistemológica e ontológica às quais a linguagem foi submetida, e que levaram à transição do paradigma classificatório e da mathêsis do classicismo para o paradigma da modernidade por volta do fim do século XVIII. A relação do homem com a finitude é determinante do modus operandi moderno de produção de saber sobre o mundo e sobre si, em particular no tangente à produção específica das ciências humanas como a biologia, a filologia e a economia. O autor indica que a diretriz intencional do saber moderno, e, por conseguinte, do homem moderno, é ainda no sentido de uma mesmificação daquilo que é Outro e, por isso mesmo, fonte de angústia. Esta tarefa é engendrada na modernidade sob um modo próprio que a distingue da apreensão representacional clássica. Ao mesmo tempo em que lhe confere uma definição, a própria condição de finitude do homem sinaliza um limite e prenuncia sua superação como conceito, na medida em que emergem as condições de possibilidade para uma nova disposição da linguagem ainda no porvir.
Ser mulher segundo Freud - Um caminho para a feminilidade?
Authors: Bastone Petra
Published: October 2020

Se, desde as primeiras escutas das histéricas, a sexualidade feminina sempre foi do interesse de Freud, que deu voz aos desejos femininos, a feminilidade, porém, é um assunto que coloca a teoria freudiana em grandes impasses e paradoxos. Afinal, o que é ser mulher de acordo com a teoria freudiana? É viver para lidar com uma inveja peniana, que correria o risco de nunca ser superada por completo? É sofrer um específico processo de passagem pelo complexo de Édipo? Muito do discurso de Freud corre pelo sentido de que a mulher tenta suprir a falta de um pênis de diversas formas, mostrando uma inferioridade que se daria a partir de uma falta anatômica. O destino maldito da mulher seria traçado pela sua anatomia segundo o autor; mas, ao mesmo tempo, ele afirma que ninguém é totalmente masculino ou feminino. Pelo fato de acreditar que ser mulher vai muito além de sua condição biológica (assim como Freud) e, diante de tantos impasses na obra de Freud, recorrerei a duas filósofas que criticam o pensamento freudiano para tentar trabalhar a questão da feminilidade no interior da obra do autor. Com o recurso ao pensamento de Judith Butler, que afirma que parte das considerações sobre a construção da feminilidade se deve a uma matriz heterossexual do desejo, e a Simone de Beauvoir, principal nome do movimento feminista, que mostra aspectos importantes do amplo alcance do privilégio masculino em nossa cultura, pretendo articular concepções diferentes do “ser mulher” e, ao mesmo tempo, tentar uma conversa (ainda que conflitante) entre os três teóricos
"Serenidade", o discurso festivo de Martin Heidegger: a questão da essência da técnica e do pensamento humano
Authors: Denker Alfred
Published: October 2020

Tradução de Deborah Moreira Guimarães e Felipe Maia da Silva
A Practical Guide to the New Feline Cardiomyopathy Consensus Statement
Authors: Pace Charlotte
Published: October 2020

In a welcome move, the American College of Veterinary Internal Medicine (ACVIM) has just published a consensus statement providing guidance on the diagnosis, management, and treatment of the cat with cardiomyopathy. Even more encouraging is that nursing guidelines have also been included in this statement. The paper has been released as ‘open access’, so anyone can access these guidelines free of charge online. The consensus statement is important because it provides an updated classification of feline cardiomyopathies, changing emphasis to different phenotypic groups, and adds a staging system, along similar lines as the ACVIM myxomatous mitral valve disease consensus statement first published in 2009 and then updated in 2019. This article provides a summary of the key points made in the consensus statement.
Differential phase imaging in full-field optical coherence microscopy using a short multimode fiber probe
Authors: Sato Manabu , Masuta Junpei , Nishidate Izumi
Published: October 2020

We demonstrate phase imaging that reduces the common phase noise in full-field optical coherence microscopy using a short multimode fiber (SMMF) probe. Using a cover glass, phase images of the SMMF and sample surfaces were measured simultaneously. Subtracting the phase of the SMMF surface as a reference, the phase drifts in the sample region are reduced. The axial and lateral resolutions were 2.3 µm and

<
4.4

µ

m

, respectively. The standard deviation of the time variation in the phase decreased from 14.3 deg to 9.2 deg and was reduced by 64% when in contact with the polymer film at the SMMF. In quantitative evaluations, the measured phases closely correspond to the phases changed by a piezoelectric device.
Deterministic design of focusing apodized subwavelength grating coupler based on weak form and transformation optics
Authors: Li Shuyi , Cai Lifeng , Gao Dingshan , Dong Jianji , Hou Jin , Yang Chunyong , Chen Shaoping , Zhang Xinliang
Published: October 2020

The focusing apodized subwavelength grating coupler (F-ASGC) has advantages of high coupling efficiency, small footprint and simple fabrication process, which make it a popular component for chip-scale coupling and testing of integrated optical circuit. However, the design of F-ASGC based on effective medium theory lacks accuracy, causing the drawbacks of peak wavelength deviation and performance degradation. In this work, we propose a deterministic design method of F-ASGC. Our grating coupler is formed by assembling various subwavelength grating units according to their complex effective indexes. The complex effective indexes of these grating units are accurately obtained by the weak form calculation. Then combining with transformation optics, we strictly analyze the F-ASGC for the first time. The simulation results show that the deterministically designed F-ASGC has high coupling efficiency of -2.51 dB, 3 dB bandwidth of 51 nm, and accurate central wavelength of 1553.1 nm. And we also fabricated it on the commercial SOI wafer. The measured maximum efficiency is -3.10 dB, the 3 dB bandwidth is 55 nm, and the central wavelength is 1551.5 nm.
In Defence of Poetry: Intertextual Dialogue and the Dynamic of Appropriation in Plutarch’s De audiendis poetis
Authors: Várzeas Marta
Published: October 2020

Intertextuality may be defined as the interaction between different texts, a dialogic relationship found especially in literary works and which the reader is asked to decipher. The absorption and tacit transformation of other texts in Plutarch’s work suggests that the intertextuality in De audiendis poetis can be approached as literary intertextuality, making it both critical and creative. The allusion to other texts is the most important thread that weaves argumentative discourse and evidences together, in other words, the benefits that can be drawn from reading the poets.
Um conjunto de instrumental têxtil da Necrópole da I Idade do Ferro da Herdade do Pêgo (Ourique, Portugal)
Authors: Gomes Francisco B.
Published: October 2020

Entre os materiais da necrópole da I Idade do Ferro da Herdade do Pêgo (Ourique) atualmente depositados no Museu Nacional de Arqueologia conta-se um conjunto de peças relacionadas com a produção têxtil, nomeadamente cossoiros e pondera ou pesos de tear. O estudo morfológico e decorativo destas peças revela a sua plena integração no panorama do instrumental têxtil regional durante o período em questão, ao passo que o seu estudo técnico demonstra a sua perfeita adequação a funções relacionadas com a fiação e a tecelagem. O significado da deposição destas peças num ambiente funerário é, de momento, difícil de precisar, podendo decorrer tanto de uma crescente valorização social e económica das atividades têxteis, rastreável noutros contextos deste período, como de um simbolismo mágico-religioso específico ligado a essas atividades e aos materiais que lhe estão associados.
Transformaciones sociodemográficas y diferenciación social del espacio residencial en el área metropolitana de Valparaíso, Chile (1992-2017)
Authors: Valdebenito Valdebenito Carlos , Álvarez Aránguiz Luis , Hidalgo Dattwyler Rodrigo , Vergara Constela Carlos
Published: October 2020

Durante los últimos treinta años, las áreas metropolitanas de Chile en general, y de Valparaíso, en particular, han experimentado significativas transformaciones en su morfología y en su población. En este artículo se busca describir, analizar y comprender la huella latente de estas transformaciones en la diferenciación del espacio residencial del “Gran Valparaíso”. La fuente de datos utilizada corresponde a los Censos de Población y de Vivienda de los años 1992, 2002 y 2017. La unidad de análisis espacial es la zona censal y el protocolo metodológico implementado involucra la aplicación combinada de técnicas de estadística descriptiva y análisis multivariado. Los resultados obtenidos acreditan un proceso incremental de fragmentación socioeconómica y demográfica del espacio residencial del Gran Valparaíso, evidenciado tanto en el número y como en el contenido de los componentes que emergen del análisis factorial, como en las zonas residenciales que se conforman.
El uso y la importancia de las redes sociales en el sector hotelero desde la perspectiva de los responsables de su gestión
Authors: Sánchez Jiménez Miguel Ángel , Fernández Alles María Teresa , Mier-Terán Franco Juan José
Published: October 2020

Cuando comenzó a percibirse las redes sociales como un factor importante que podía afectar al negocio empresarial muchas organizaciones la han tenido en cuenta para el desarrollo de su gestión. Esta utilización de las redes sociales es especialmente relevante en las empresas turísticas ya que dependen en gran medida de la opinión y la experiencia del cliente. Así, en este estudio se ha planteado conocer el uso y la importancia de las redes sociales en el sector hotelero a través de una investigación cualitativa mediante entrevistas a diez responsables de la gestión de redes sociales de establecimientos hoteleros. De esta manera se ha tenido en cuenta el marco teórico para obtener las categorías y realizar las preguntas de investigación. Posteriormente, mediante un análisis de contenido a través del software Nvivo 11, se obtuvo inductivamente subcategorías con características comunes que se dividieron en unidades de análisis mediante la codificación de los datos, facilitando así la interpretación de la información. En los resultados los gestores de redes sociales entrevistados destacaron la importancia que tienen los medios sociales en el sector hotelero para relacionarse e interactuar con los usuarios, de manera que consideran esencial el planteamiento de objetivos propios para este ámbito y el desarrollo de estrategias dependiendo de las redes sociales en las que vayan a intervenir. Así, las ventajas más destacadas son la visibilidad, la facilidad de acceder a la información y la posibilidad de tener una mejor comunicación, relación e interacción con los usuarios.
La puesta en valor turístico del patrimonio cultural en fase de desaparición. Una oportunidad para los territorios de interior. Los casos de los monasterios de Vilabertran, Scala Dei y Escornalbou, en Catalunya
Authors: Prat Forga Josep Maria
Published: October 2020

Los territorios de interior que poseen un importante patrimonio cultural en fase de destrucción tienen la oportunidad de restaurarlo y rehabilitarlo, poniéndolo en valor turístico. De esta manera, no solamente reafirman el sentimiento de identidad local y promocionan su cultura sino que también ayudan a su desarrollo económico, recibiendo nuevos visitantes, ávidos de consumir cultura e historia, y que, no solamente redescubren estos conjuntos monumentales, habiéndose informado previamente de las principales características de la visita,  sino que, además, efectúan otros gastos adicionales en sus alrededores, lo que permite crear nuevos puestos de trabajo y mejorar la renta personal de la comunidad local.En este trabajo se analiza la evolución de la cantidad anual de visitantes recibidos en los últimos quince años en tres complejos religiosos que sufrieron su abandono y destrucción a partir de la desamortización de Mendizábal, y cuya restauración y puesta a punto ha permitido situarlos dentro del circuito turístico y cultural de los monasterios catalanes.Para ello se ha utilizado una serie de datos estadísticos oficiales y descriptivos; así como los resultado de una encuesta personal realizada al azar a los visitantes de estos monumentos, confirmando que manifiestan un alto grado de satisfacción con la visita y que están dispuestos a repetirla o, al menos, promocionarla.
Hacer de la necesidad virtud. Evolución de la identidad nobiliaria entre las élites canarias en la Edad Moderna: los memoriales de los Salazar de Frías
Authors: Gutiérrez-de-Armas Judit , Precioso-Izquierdo Francisco
Published: October 2020

El objetivo principal de este artículo es analizar el proceso de construcción de la identidad nobiliaria de las élites canarias en el periodo moderno. Para ello, proponemos el estudio de los diferentes memoriales elaborados a lo largo de los siglos XVII y XVIII por diferentes miembros de la familia Salazar de Frías, caso paradigmático de la nueva nobleza canaria que hizo fortuna entre los estratos superiores de la sociedad insular. Precisamente, para legitimar su nueva posición, pusieron en marcha toda una serie de iniciativas de autorrepresentación familiar que les permitió hacer frente a ciertas necesidades en momentos de especial dificultad para sus miembros. En este trabajo analizamos la evolución de la idea de nobleza forjada por los Salazar de Frías mediante el examen de los hitos más significativos de la identidad privilegiada y diferenciada que lograrán recrear en diversos memoriales de servicios.
La evolución del papel político de la nobleza española en el tránsito de la Edad Moderna a la Contemporánea: El ejemplo de los Fernández de Córdoba
Authors: Molina Recio Raúl
Published: October 2020

Esta investigación trata de acercarse a la evolución del poder político nobiliario entre los siglos XV y XIX, partiendo del ejemplo del linaje Fernández de Córdoba. Pretendemos, en primer lugar, mostrar de forma cuantitativa a través del análisis de los cargos ejercidos por el grupo la presencia de la nobleza en diversas instituciones de la Monarquía Hispánica como son la alta administración, el ejército y la jerarquía eclesiástica. Además de explicar el porqué de este proceso de extensión del poder del estamento y su cronología, trataremos de responder a dos interrogantes centrales, como son el desplazamiento del grupo de las instituciones políticas durante el siglo XVIII llevado a cabo por los Borbones, así como su adaptación (si la hubo) al entorno del Liberalismo del siglo XIX para entender el papel político de la nobleza en el primer siglo de la Contemporaneidad.
Fiebres, arroz e insalubridad: el caso del Ampurdán (1783-1787)
Authors: Pometti Benítez Kevin Albert
Published: October 2020

Las fiebres palúdicas han estado, en frecuentes ocasiones a lo largo de la historia, relacionadas con los efectos de las actividades antrópicas sobre las condiciones ambientales preexistentes de las regiones en las que han acontecido. Por ello, en este trabajo analizamos las causas ambientales que caracterizan las regiones endémicas de malaria como es el caso de la región del Ampurdán (NE península ibérica), donde ya con anterioridad al siglo XVIII, pero, en especial, en el siglo XIX se extendió el cultivo del arroz de forma intensiva. También, es preciso considerar las condiciones de higiene y de falta de la misma que pudieron propiciar o incrementar los efectos de las epidemias de fiebres en la población. Por otra parte, analizaremos los distintos métodos curativos empleados por dos médicos corresponsales de la Real Academia Médico-Práctica de Barcelona, cuyos testimonios se enmarcan en el contexto de la epidemia de fiebres palúdicas que asoló la península ibérica, entre 1783 y 1786.
Type Inference of Simple Recursive Functions in Scala
Authors: Nagy Gergely , Oláh Gábor , Porkoláb Zoltán
Published: October 2020

Scala is a well-established multi-paradigm programming language known for its terseness that includes advanced type inference features. Unfortunately this type inferring algorithm does not support typing of recursive functions. This is both against the original design philosophies of Scala and puts an unnecessary burden on the programmer. In this paper we propose a method to compute the return types for simple recursive functions in Scala. We make a heuristic assumption on the return type based on the non-recursive execution branches and provide a proof of this method's correctness. The algorithm does not have a significant effect on the compilation speed. We implemented our method as an extension prototype in the Scala compiler and used it to successfully test our method on various examples. The compiler extension prototype is available for further tests.
Fascismo. O pior crime contra a democracia
Authors: Martinez Vinício Carrilho
Published: October 2020

O texto é um tipo de breviário sobre o assim chamado “bolsonarismo”. Um breviário porque ninguém será capaz de esgotar suas particularidades e inscrições na realidade política, social, econômica, cultural. Também se propõe como breviário no sentido de que algumas breves ilações irão demarcar o texto como antídoto ao substrato fascista, às vezes até com requintes totalitários ou afagos nazistas, na moeda de troca de Goebbels. O bolsonarismo não escapa aos piores lances do clássico cesarismo, sendo este uma demonstração em particular do bonapartismo. Por vezes, ainda se pode relacionar o bolsonarismo ao berlusconismo italiano.
"Meu twitter, minhas regras”: as pautas de costumes na educação bolsonarista
Authors: Siqueira de Guimarães Rafael , Rodrigo Braga de Oliveira Cleber
Published: October 2020

O objetivo deste estudo foi analisar como as pautas de costumes estiveram presentes em um dos espaços oficiais, o twitter do ex-Ministro da Educação Abraham Weintraub, que esteve à frente do Ministério da Educação, entre abril de 2019 e junho de 2020. Para tanto, nós nos dedicamos a examinar os discursos publicados nas postagens – chamadas de tuítes, nessa rede social – que identificamos como referentes a pautas de costumes, ligadas à moralidade, tendo especificidade de se relacionarem a alguma ação do MEC ou não. Como resultado dessa análise, encontramos processos comuns ao bolsonarismo, como a deslegitimação do conhecimento, em especial das Ciências Humanas e Artes, as teorias alarmistas sobre balbúrdia nas Universidades, a inversão acusatória contra opositores e marcas de rancor expressas em apropriações discursivas advindas das redes sociais, como a trollagem e a lacração. A atuação do ex-dirigente expõe como essa comunicabilidade com a massa de apoio bolsonarista o colocou num papel de vice-liderança e, ao mesmo tempo, impactou as ações do Ministério, o qual balizou suas decisões em pautas morais.
Factors Affecting the Use of Field Trip in Teaching and Learning Biology in College of Education Akwanga, Nasarawa State
Authors: Oganya Ogenyi Deborah , Emmanuel. E Audu , Luper Tsenum Joseph
Published: October 2020

The research provides an appraisal of the factors affecting the use of field tripin teaching and learning of Biology in the College of Education Akwanga, Nasarawa State. It provides an analysis of the nature of field tripin teaching and learning biology and its significance. The research not only proffers a methodology of teaching and learning of biology but also elucidate the factors affecting its use. Questionnaires were administered and ninety-one of them returned for analysis. The analysis used was a simple percentage to ascertain the use of field trips in teaching and learning of Biology in the College of Education Akwanga, Nasarawa State. From the findings, it was clearly seen that the use of field trip in teaching and learning biology is very vital as can be shown in the use of field trip in teaching and learning biology is very vital as shown in the summary of the data collected, 827 responses representing 39.55% strongly agreed with the twenty-three questions or statements presented in the questionnaires. 1005 responses representing 48.10% agreed with the twenty-three questions or statements presented in the questionnaires. Only 187 responses representing 8.94% disagreed with the twenty-three questions or statements presented in the questionnaires and 72 responses representing 3.44% strongly disagreed with the twenty-three questions or statements presented in the questionnaires. The percentage of respondents that strongly agreed and agreed was higher than the percentage of respondents that disagreed or strongly disagreed.