bluuebunny/crossref_metadata_2025 huggingface dataset:
Studying the Metaverse Effect on its Users
Authors: Taher Ghazal  , Issa Ghassan , A. Al Dmour Nidal , M. AlzoubiZ Haitham
Published: March 2023

This research is set to answer the question how Metaverse can be a dangerous space for its users. Metaverse is a collection of Meta applications such as Facebook, Instagram, WhatsApp and Oculus that is integrated into virtual reality (VR) and augmented reality (AR). To answer the question, different issues that were undertaken in the history of Meta and its CEO, Mark Zuckerberg, was taken into account to see the potential negative effects it will have on end-users.

The potential issues Metaverse can have includes issues with uneven power distribution, issues with cyber security and privacy threats, and negative impact on the user’s mental health. An interview was conducted and the results supported the prior claims, with an emphasis on the dangers of lack of security and privacy leaks and breaches, followed by mental health concerns, then lack of regulations, followed by spread of misinformation and abuse of power. The solutions to these issues consisted of adding and adopting better regulations, integrating a monitoring system, and including a function for tracking and limiting end-user’s screentime. Alas, technology and the internet are ever-changing and needs constant evaluation and regulations, especially if it is from a big tech-company such as Meta. A company is useless without its customers, so keeping them safe should always be a top priority.
The Performance of Modified Progressive Mean Control Chart with different constant value.
Authors: Jalbani Tarique Hussain , Shabbir Taha
Published: March 2023

Any manufacturing process cannot produce exactly identical items. In all kinds of processes, a certain amount of variability is present, which causes such kind of variations in the products. A modified progressive mean (MPM) control chart has recently been proposed plotting the statistic which uses the present data as well as the past data. We used the modified progressive mean (MPM) control chart with a different value of constant K0. The results showed an improved performance of the proposed chart for smaller, moderated and larger shifts in terms of power.
The Effects of Job Anxiety Following COVID-19 on Employment Preparation Behavior and Satisfaction with Tourism Major College Students: Mediating Effect of Self-Efficacy and Resilience
Authors:   The Convergence Tourism Contents Society, Kim Hyun Ju
Published: March 2023

Purpose: Through the mediating effect of self-efficacy and resilience, the process of job anxiety affecting job preparation behavior and major satisfaction of tourism major college students experiencing COVID-19 is identified, and also the psychological path of college students following COVID-19 is classified to suggest more useful directions for improvement.
Methods: Data were collected from 360 students majoring in tourism at two-year colleges and four-year universities by conducting an online survey. The participants in the study were 164 male students (45.6%) and 196 female students (54.4%), and the collected data were analyzed using SPSS 23.0.
Results: As a result of the analysis, it was found that job anxiety had a negative (-) effect on self-efficacy and resilience, and self-efficacy and resilience had a positive (+) effect on job preparation behavior and major satisfaction. It was verified that both self-efficacy and resilience play a mediating role in the relationship between job anxiety and job preparation behavior and also between job anxiety and major satisfaction.
Conclusion: Research has shown that increasing self-efficacy and resilience, even in situations where employment is unstable, has a positive effect on job preparation behavior and major satisfaction.
A Study on the Characteristics of Social Media Information, Engagement, Brand Attitudes, Behavioral Intentions of Travel Agents
Authors:   The Convergence Tourism Contents Society, Shim Munsup
Published: March 2023

Purpose: The purpose of this study is to examine the impact of travel agency social media information characteristics on engagement, brand attitudes, satisfaction, and loyalty. The proliferation of smartphones has led to the expansion of social media creation and use, and social media has become an important marketing medium for brand formation and information delivery. This study aims to analyze the effects of social media information characteristics and engagement, a state of information immersion, on brand attitudes and behavioral intentions.
Methods: The survey was conducted with a sample of people who have used travel agency social media. A self-administered survey using simple random sampling was conducted from July 18 to August 31, 2022, and a total of 317 copies were used for analysis. Frequency analysis, validity and reliability analysis, correlation analysis, factor analysis, and regression analysis were conducted using the SPSS 22.0 program.
Results: The impact of travel agency social media information characteristics on engagement was found to be significantly influenced by quality, liveliness, professionalism, and interactivity among social media information characteristics; engagement was found to have a significant impact on brand attitude; brand attitude has a defining effect on satisfaction and loyalty; and satisfaction has an impact on loyalty.
Conclusion: This study provides a theoretical foundation for future empirical studies in the same field by establishing the conceptualization of marketing variables and measurement factors using social media, measuring their constructs, and studying their relationships.
A Study on Characteristics of Sequential Landscape for Road Used by Visitors to Approach Main Destinations for Scenic Road Construction: A Case Study on Miryang-si
Authors:   The Convergence Tourism Contents Society, Kim Do-Hyeon
Published: March 2023

Purpose: Recently, there have been increasing efforts to develop tourism content for exploring regional economies. Among them, development of scenic roads through road maintenance is attracting attention as an alternative way for boosting tourism and local economy, since more people use private cars in contemporary society. The purpose of this study is to clarify scenic characteristics of each access route for main destinations in Miryang-si and establish basic data for sequence scenic road maintenance.
Methods: To clarify objectives, this study targeted top 15 destinations, analyzed their circulation system and access routes, landcape characteristics for each route and their utilization methods, and relevant implications.
Results: According to the results, 3 national roads, 3 local roads, and 10 other roads were used as main routes for 15 desginations. The external landscape view-based sequence landscape maintenance method is efficient for national road routes by utilizing farmlands around roads and street trees at city entrance. However, local road routes have slower vehicle speeds and various short-range landscapes, so they show high efficiency in utilizing visual elements but need additional plans, such as parking places. Other town and village roads are mostly narrow and short, and scenic experience of walking around access road was found to be more efficient than using cars.
Conclusion: In order to improve and maintain scenic roads, there must be a prior investigation in consideration of current situations and this study is designed for such reasons. The follow-up studies, such as verifying efficiency of scenic road construction for each route, can be used as grounds for suggesting directions.
Regional golden monkey (Cercopithecus mitis kandti) conservation action plan 2023–2028
Authors: Tuyisingize Deogratias , Cipolletta Chloé , Eckardt Winnie , Caillaud Damien , Musana Abel , Muvunyi Richard , Turinawe Moses , Amanya Samuel , Mburanumwe Innocent , Katutu Jacques , Shalukoma Chantal , Ndagijimana Felix , Stoinski Tara S. , Kaplin Beth A.
Published: March 2023

The golden monkey, Cercopithecus mitis kandti, an Endangered subspecies of blue monkey, is found in only two small populations in the central part of the Albertine Rift region in Central/East Africa. Since the 1950s, the habitat of golden monkeys has been lost or degraded in the Virunga massif (Democratic Republic of the Congo, Rwanda, Uganda), including a reduction of approximately 50% in the Volcanoes National Park (VNP), the Rwandan part of the Virunga massif, and by a staggering 98% in the Gishwati forest located in Rwanda. As human disturbance continues within the golden monkey habitat, pressure on the remaining small and fragmented populations may result in the extinction of this subspecies. Consequently, a regional conservation action plan was developed in collaboration with conservationists, park managers, researchers, and local communities from the three countries where golden monkeys occur to address threats to the species.
Cardiovascular Safety in Type 2 Diabetes With Sulfonylureas as Second-line Drugs: A Nationwide Population-Based Comparative Safety Study
Authors: Wang Huan , Cordiner Ruth L.M. , Huang Yu , Donnelly Louise , Hapca Simona , Collier Andrew , McKnight John , Kennon Brian , Gibb Fraser , McKeigue Paul , Wild Sarah H. , Colhoun Helen , Chalmers John , Petrie John , Sattar Naveed , MacDonald Thomas , McCrimmon Rory J. , Morales Daniel R. , Pearson Ewan R. ,   Scottish Diabetes Research Network Epidemiology Group, Blackbourn Luke , Cunningham Scott , Gibb Fraser , Leese Graham , Lindsay Robert , McAllister David , McGurnaghan Stuart , Philip Sam
Published: March 2023

OBJECTIVE

To assess the real-world cardiovascular (CV) safety for sulfonylureas (SU), in comparison with dipeptidyl peptidase 4 inhibitors (DPP4i) and thiazolidinediones (TZD), through development of robust methodology for causal inference in a whole nation study.

RESEARCH DESIGN AND METHODS

A cohort study was performed including people with type 2 diabetes diagnosed in Scotland before 31 December 2017, who failed to reach HbA1c 48 mmol/mol despite metformin monotherapy and initiated second-line pharmacotherapy (SU/DPP4i/TZD) on or after 1 January 2010. The primary outcome was composite major adverse cardiovascular events (MACE), including hospitalization for myocardial infarction, ischemic stroke, heart failure, and CV death. Secondary outcomes were each individual end point and all-cause death. Multivariable Cox proportional hazards regression and an instrumental variable (IV) approach were used to control confounding in a similar way to the randomization process in a randomized control trial.

RESULTS

Comparing SU to non-SU (DPP4i/TZD), the hazard ratio (HR) for MACE was 1.00 (95% CI: 0.91–1.09) from the multivariable Cox regression and 1.02 (0.91–1.13) and 1.03 (0.91–1.16) using two different IVs. For all-cause death, the HR from Cox regression and the two IV analyses was 1.03 (0.94–1.13), 1.04 (0.93–1.17), and 1.03 (0.90–1.17).

CONCLUSIONS

Our findings contribute to the understanding that second-line SU for glucose lowering are unlikely to increase CV risk or all-cause mortality. Given their potent efficacy, microvascular benefits, cost effectiveness, and widespread use, this study supports that SU should remain a part of the global diabetes treatment portfolio.
Study protocol for discharge on day of surgery after hip and knee arthroplasty from the Center for Fast-track Hip and Knee Replacement
Authors: Lindberg-Larsen Martin , Varnum Claus , Jakobsen Thomas , Andersen Mikkel Rathsach , Sperling Kim , Overgaard Søren , Hansen Torben Bæk , Jørgensen Christoffer Calov , Kehlet Henrik , Gromov Kirill
Published: March 2023

Background and purpose: Limited data exists on the implementation process and safety of discharge on the day of surgery after primary hip and knee arthroplasty in a multicenter setting. We report our study protocol on the investigation of the feasibility, safety, and socioeconomic aspects following discharge on day of surgery after hip and knee arthroplasty across 8 fast-track centers.Patients and methods: This is a study protocol for a prospective cohort study on discharge on day of surgery from the Center for Fast-track Hip and Knee Replacement. The collaboration includes 8 centers covering 40% of the primary hip and knee arthroplasty procedures undertaken in Denmark. All patients scheduled for surgery are screened for eligibility using well-defined inclusion and exclusion criteria. Eligible patients fulfilling discharge criteria will be discharged on day of surgery. We expect to screen 9,000 patients annually.Duration and outcome: Patients will be enrolled over a 3-year period from September 2022 and reporting of results will run continuously until December 2025. We shall report the proportion of eligible patients and patients discharged on day of surgery as well as limiting factors. Readmissions and complications within 30 days are recorded with real-time follow-up by research staff. Furthermore, patient-reported information on willingness to repeat discharge on day of surgery, contacts with the healthcare system, complications, and workability is registered 30 days postoperatively. EQ-5D, Oxford Knee Score, and Oxford Hip Score are completed preoperatively and after 3 months and 1 year. Finally, outcome data will be used in the development of a prediction model for successful discharge on the day of surgery.
Comparison of Convolutional Neural Network (CNN) Models in Face Classification of Papuan and Other Ethnicities
Authors: Yenusi Yuni Naomi , Suryasatriya Trihandaru  , Setiawan Adi
Published: March 2023

The face of the Papuan people is unique when compared to other ethnic groups in Indonesia, even in Papua itself there are tribes whose differences can also be identified in general, namely coastal people and mountainous people. determined to identify Papuan faces. The faces of Papuans can be identified with the architectural models in Convolutional Neural Networks (CNN) such as VGG16, VGG-19, ResNet-50 and MobileNet v1 and Mobilenet v2. The best model is the Mobile Net v1 architectural model for Papuan and Non-Papuan Face Recognition with 0.95 or 95% accuracy.
Quasi-free states on algebras of multicomponent commutation relations
Authors:   ,   Swansea University, Othman Nedal
Published: March 2023

Let X = R² and let V be a finite-dimensional complex inner product space. Let C : X² → L (V ⊗²) be a continuous function such that, for each (x, y) ∈ X², C(x, y) is a unitary operator in V ⊗², C∗(x, y) = C(y, x), and the functional Yang-Baxter equation is satisfied. The dissertation deals with the multicomponent commutation relations governed by the function C, see [A. Liguori, M. Mintchev, Comm. Math. Phys. 169 (1995) 635–652]. We introduce the ∗-algebra of the C-multicomponent commutation relations (C-MCR algebra). We propose definitions of a gauge-invariant quasi-free state and of a strongly quasi-free state on the C-MCR algebra, A. Under restrictive assumptions on the function C, we construct a class of gauge-invariant quasi-free states on A, which, for some functions C, are also strongly quasi-free. We show that, when dim V = 1 (i.e., when we deal with the anyon commutation relations), among all gauge-invariant quasi- free states on A, only the Fock state is strongly quasi-free. In the case dim V = 2 (i.e., when we deal with two-component systems), we present a non-trivial class of examples of function C to which our theory is applicable, and hence, we can construct gauge-invariant quasi-free states, or even strongly quasi-free states on A.
Clinical Pattern and Spectrum of Atypical Endometriosis: A Series of 5 Cases
Authors: Shirazi Nadia , Nautiyal Ruchira , Jindal Rashmi
Published: March 2023

Endometriosis refers to the extrauterine presence of hormonally active endometrial glands and stroma. This ectopic endometrial tissue exhibits cyclic bleeding, inflammation, fibrosis and leads to formation of adhesions. Endometriosis affects about 10% to 15% of women between 15 to 45 years of age. Clinical presentations vary from infertility, dysmenorrhoea, chronic pelvic pain, deep dyspareunia and even bleeding at external sites like the umbilicus. Besides involving fallopian tubes, bowel, liver, thorax, pericardium, pleura etc, the most commonly affected areas in the gastrointestinal tract are the descending colon, rectosigmoid, appendix, and ileo-caecum in descending order of frequency. This case series highlights some unusual presentations of endometriosis along with co-existence of other ovarian pathologies which are not frequently encountered in clinical practice. This series also highlights the role of preoperative radiology for an adequate clinical diagnosis and complete surgical excision.
PENGARUH SUPLEMENTASI TEPUNG MAGGOT BLACK SOLDIER FLY (BSF) DALAM RANSUM TERHADAP KANDUNGAN LOW DENSITY LIPOPROROTEIN (LDL) DAN HIGH DENSITY LIPOPROROTEIN (HDL) DARAH AYAM JOPER BETINA
Authors: Laila Dwi Nur , Suharyati Sri , Sutrisna Rudy , Fathul Farida
Published: March 2023

Penelitian ini bertujuan untuk mengetahui dosis terbaik pemberian tepung maggot terhadap LDL dan HDL darah ayam joper betina. Penelitian ini dilaksanakan pada Februari – Maret 2022 dan berlokasi di Peternakan Ayam Joper Daffa, Labuhan Dalem, Kecamatan Tanjung Senang, Kota Bandar Lampung. Pemeriksaan LDL dan HDL dilakukan di Laboratorium Klinik Pramitra Biolab Indonesia, Way Halim, Bandar Lampung. Rancangan percobaan yang  digunakan adalah Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan yang diberikan yaitu ransum tanpa suplementasi tepung maggot (P0), ransum dengan suplementasi 5 % tepung maggot (P1), ransum dengan suplementasi 10 % tepung maggot (P2), dan ransum dengan suplementasi 15 % tepung maggot (P3).  Data yang diperoleh dianalisis menggunakan analisis ragam dan diuji lanjut menggunakan uji Beda Nyara Terkecil (BNT). Hasil analisis ragam menunjukkan bahwa suplementasi tepung maggot sampai 15 % tidak berpengaruh nyata (P>0,05)  terhadap kadar Low Density Lipoprotein (LDL) dan hasil analisis ragam menunjukkan ransum tanpa suplementasi tepung maggot (P0) dengan ransum ditambah suplementasi tepung maggot 10 % (P2) berpengaruh nyata (P<0,05) terhadap High density lipoprotein (HDL) darah ayam joper betina.
JUMLAH ERITROSIT, KADAR HEMOGLOBIN, DAN NILAI HEMATOKRIT KAMBING SABURAI BETINA YANG TERINFESTASI JENIS CACING SALURAN PENCERNAAN DAN EIMERIA SP., DI KECAMATAN GISTING KABUPATEN TANGGAMUS
Authors: Hakiki Nurul , Suharyati Sri , Husni Ali , Hartono Madi
Published: March 2023

Penelitian ini bertujuan untuk mengetahui jumlah eritrosit, kadar hemoglobin dan nilai hematokrit kambing Saburai betina yang terinfestasi jenis cacing saluran pencernaan dan Elmeria sp., di Kecamatan Gisting Kabupaten Tanggamus.  Penelitian ini dilaksanakan pada Maret-Mei 2022 dengan pengambilan sampel darah kambing Saburai di Kelompok Ternak Kabupaten Tanggamus. Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 4 ulangan dari sampel darah kambing Saburai. Perlakuan yang digunakan adalah P1: kambing Saburai yang terinfestasi Eimeria sp., P2: kambing Saburai yang terinfestasi Haemonchus sp., dan Eimeria sp., dan P3: kambing Saburai yang terinfestasi Haemonchus sp., Mecistocirrus digitatus dan Eimeria sp.  Analisis jumlah eritrosit dan nilai hematokrit darah dilaksanakan di Laboratorium Patologi, Balai Veteriner Lampung dan analisis kadar hemoglobin dilaksanakan di Laboratorium Fisiologi Ternak, Jurusan Peternakan, Fakultas Pertanian, Universitas Lampung.  Data hasil pengamatan dianalisis dengan sidik ragam pada taraf (P<0,05).  Hasil penelitian ini menunjukkan bahwa infestasi jenis cacing saluran pencernaan dan Eimeria sp., pada kambing Saburai tidak memberikan pengaruh yang nyata (P<0,05) terhadap jumlah eritrosit, kadar hemoglobin dan nilai hematokrit.  Jumlah eritrosit tertinggi pada kambing Saburai yang terinfestasi Eimeria sp., (11,03x106/µl) dan terendah yang terinfestasi gabungan Haemonchus sp., dengan Eimeria sp., (7,84 x106/µl).  Kadar hemoglobin tertinggi pada kambing Saburai yang terinfestasi gabungan Haemonchus sp., Mecistocirrus digitatus dengan Eimeria sp., (11,25 g/dL) dan terendah yang terinfestasi Eimeria sp., (10,40 g/dL).  Nilai hematokrit tertinggi pada kambing Saburai yang terinfestasi Eimeria sp., (32,65%), dan terendah yang terinfestasi gabungan Haemonchus sp., Mecistocirrus digitatus dengan Eimeria sp., (26,68%).
The Impact of the Application of PSAK 72 on the Financial Performance of Property Companies
Authors: Atmoko Alfriadi Dwi
Published: March 2023

This study aims to analyze revenue recognition based on PSAK 72 and its impact on the financial performance of property companies listed on the Indonesia Stock Exchange in 2019. The sample companies are 18, but only five implemented PSAK 72 in 2019. The five companies jointly implemented PSAK 71 on January 1, 2020, thus causing retrospective adjustments in 2018 and 2019 in its retained earnings that will have an impact on the statement of financial position and company performance. The method in this research uses the descriptive qualitative method. The data analysis technique used analyzes the five steps of the revenue recognition procedure based on PSAK 72. The results of this study show differences in the application of revenue recognition based on PSAK 72 with the previous standard resulting in changes in the value of revenue originating from customer contracts. Seen in each company's CR value has decreased, and the DTA value has increased for the five companies. At NPM, two companies experienced a decline due to the implementation of PSAK 72. However, the NPM at three companies has actually experienced an increase.
A k-mer based metaheuristic approach for detecting COVID-19 variants
Authors: ARSLAN Hilal
Published: March 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to coronaviridae family and a change in the genetic sequence of SARS-CoV-2 is named as a mutation that causes to variants of SARS-CoV-2. In this paper, we propose a novel and efficient method to predict SARS-CoV-2 variants of concern from whole human genome sequences. In this method, we describe 16 dinucleotide and 64 trinucleotide features to differentiate SARS-CoV-2 variants of concern. The efficacy of the proposed features is proved by using four classifiers, k-nearest neighbor, support vector machines, multilayer perceptron, and random forest. The proposed method is evaluated on the dataset including 223,326 complete human genome sequences including recently designated variants of concern, Alpha, Beta, Gamma, Delta, and Omicron variants. Experimental results present that overall accuracy for detecting SARS-CoV-2 variants of concern remarkably increases when trinucleotide features rather than dinucleotide features are used. Furthermore, we use the whale optimization algorithm, which is a state-of-the-art method for reducing the number of features and choosing the most relevant features. We select 44 trinucleotide features out of 64 to differentiate SARS-CoV-2 variants with acceptable accuracy as a result of the whale optimization method. Experimental results indicate that the SVM classifier with selected features achieves about 99% accuracy, sensitivity, specificity, precision on average. The proposed method presents an admirable performance for detecting SARS-CoV-2 variants.
Senkrosıkıştırma dönüşümü ve derin transfer öğrenimi ile Alzheimer hastalığının EEG tabanlı otomatik tespiti
Authors: POLAT Hasan
Published: March 2023

Alzheimer hastalığı, demansın en sık görülen türü olan ilerleyici bir nörodejeneratif bozukluktur. Hafıza kaybı, bilişsel kabiliyetlerde azalma ve davranışsal sorunlara yol açarak, günlük yaşamı derinden etkilemektedir. Hastalıkla mücadelede en önemli adımlardan biri hızlı ve doğru tanının konmasıdır. Dolayısıyla, bilgisayar destekli tanı sistemlerinin histopatolojik analizlere alternatif olarak geliştirilmesi önem arz etmektedir. Bu çalışmada, Alzheimer hastalığının otomatik olarak tespitinde EEG tabanlı bir sınıflandırma modeli tanıtılmıştır. Önerilen model EEG senkrosıkıştırma temsillerinin çeşitli uyarlanmış ön eğitimli derin evrişimsel sinir ağı mimariler ile sınıflandırılmasından oluşmaktadır. Senkrosıkıştırma yöntemi, EEG işaretlerini zamanla değişen salınım özelliklerine sahip görüntü örüntülerine dönüştürmek için kullanılmıştır. Akabinde ise EEG görüntüleri ön eğitimli SqueezeNet, ResNet, InceptionV3 ve MobileNet derin mimarilerine girdi olarak sunulmuş ve elde edilen sınıflandırma performansları karşılaştırılmıştır. Deneyler, 19 elektrottan (Fp1, Fp2, Fz, F3, F4, F7, F8, Cz, C3, C4, T3, T4, Pz, P3, P4, T5, T6, O1 ve O2) kayıt edilen EEG işaretlerinin her biri için ayrı ayrı uygulanmıştır. Bulgular P3 ve T5 kanallarının Alzheimer tespitinde en etkin serebral konumlar olduğunu ve en iyi sınıflandırma doğruluğunun InceptionV3 modeli ile elde edildiğini göstermiştir. InceptionV3 modeli ile her iki kanal için sınıflandırma doğrulukları sırasıyla %89.50 ve %90.57 olarak elde edilmiştir. Ayrıca serebral korteksteki elektriksel aktivitelerin hastalığa ilişkin karakteristik dinamikleri en belirgin olarak parietal ve tempoaral loblarda yansıttığı gözlemlenmiştir.
Classification of Parkinson’s Disease using Speech Signal with Machine Learning and Deep Learning Approaches
Authors: Rahman Senjuti , Hasan Mehedi , Sarkar Ajay Krishno , Khan Fayez
Published: March 2023

Parkinson's disease (PD) is a chronic neurological condition that is growing in prevalence and manifests both motor and non-motor symptoms. Most PD patients have trouble speaking, writing, and walking during the early stages of the disease. Analysis of speech problems has been effective in identifying Parkinson's disease. According to studies, 90% of Parkinson's disease patients experience speech problems. Even though there is no known cure for Parkinson's disease, using the right medication at an early stage can greatly reduce the symptoms. One of the key categorization issues for the diagnosis of Parkinson's disease is the correct interpretation of speech signals. The major goal of this project is to use deep learning and machine learning approaches to predict and categorize PD patients at an early stage. A trustworthy dataset from the UCI repository for Parkinson disease has been used to evaluate the method's performance. Several classification models are successfully used in this study for classification tasks, including Extreme Gradient Boosting (XGBoost), Ada Boost, Light Gradient Boosting Machine, CatBoost, Gradient Boosting, Random Forest, Ridge, Decision Tree, Logistic Regression, K Neighbors, SVM - Linear Kernel, Naive Bayes, and deep neural networks (DNN1, DNN2, DNN3). The Extreme Gradient Boosting classifier achieved the greatest classification accuracy of 92.18% (among the machine learning classifiers). By using the chosen features as input, the three layer deep neural network (DNN2) has the best accuracy of 95.41% amongst deep learning techniques. The collected results indicate that deep neural networks performed better than machine learning methods.
Development of Student Moral Learning Applications as an Effort to Strengthen Character Education for Elementary School Students
Authors: Gusti Utari Akhir , Akbar Habi , Rismawati Rismawati , Putri Aulia Rama , Sintya Dilla
Published: March 2023

The development of technology in the world of educationencourages  the educational process to be more advanced and flexible.  The introduction of technology to students aims to  make them have extensive knowledge and experience to be used in their lives in the future.  Kuriculum 2013 emphasizes the panyof intellectual, emotional, and spiritual intelligence.  In its implementation, there are still few  learning media available that can increase spiritual intelligence. So far, learning media has only been aimed at intellectual and emotional intelligence, even though spiritual intelligence has an important role in building the character of students. Therefore, it is necessary to develop learning media that can increasethe 3 intelligences, especially spiritual intelligence. The Student Learning Application (BAS) is an application that is integrated with moral strengthening in students.  The type of research used is Research and development with 4D models (define, design, develop, and dissminate). In this study, it only reached the stage of developing with validity testing and small-scale testing. Thedata analysis techniques are qualitative and quantitative.  The research was conducted at  SDN 18 Air Tawar Timur, SDN 25 Air Tawar Timur, and SD Pembangunan Universitas Negeri Padang. Data collection techniques are carried out by observation, interviews, distributing product validation questionnaires, and  response test questionnaires to students and   elementary school teachers. The results of the study obtained results that the media was valid and the response test obtained quite good results. This learning media  can be used as an alternative in an effort to strengthen spiritual values in learning media in schools.
A IMPORTÂNCIA DO USO DA HISTÓRIA DA MATEMÁTICA NOS PROCESSOS EDUCATIVOS EM ÁLGEBRA LINEAR
Authors: Dias Renan Marcelo da Costa , Brandemberg João Cláudio
Published: March 2023

O presente artigo contém elementos de uma pesquisa de mestrado e tem por objetivo responder a seguinte questão: Que aspectos intrínsecos aos processos de ensino e de aprendizagem dos conceitos de Dependência e Independência Linear sinalizam a importância de uma abordagem didática desses conceitos balizada pela História da Matemática? Para tal, realizou-se uma pesquisa bibliográfica em autores que discutem as dificuldades encontradas pelos estudantes quando estes lidam com os conceitos de Dependência e Independência Linear e ainda em estudiosos que tratam do papel do formalismo e da axiomatização nos processos educativos em Álgebra Linear. Apesar das linguagens formal e axiomática serem apontadas pela literatura brasileira como fatores complicadores da compreensão dos conceitos em foco, na verdade configuram-se em elementos chave da disciplina, uma vez que possibilitam o entendimento do caráter unificador e generalizante da Álgebra Linear, o qual desponta de sua própria constituição histórico-epistemológica. Desse modo, o desafio do professor consiste em emprestar funcionalidade a esse formalismo e a essa axiomatização e, desse modo, a História da Matemática emerge como um importante provedor de recursos didáticos para este fazer.
COMPARING LEXICAL DENSITY IN TEACHER TALKS: ELEMENTARY SCHOOL AND HIGHER EDUCATION LEVEL
Authors: Ismail Nyak Mutia , Yoestara Marisa , Jamilah Sitti
Published: March 2023

Teacher talk must be specific, clear, concise, and comprehensible for students as the target interlocutors. This study aimed to characterize lexical density in teacher talks of elementary school teachers and university lecturers during teaching. A qualitative descriptive technique was used involving lexico-grammar analysis from an SFL perspective. The subjects of this study were three elementary school teachers (6th-grade teachers) and three university lecturers (English lecturers) who were voluntarily recorded during their teaching time; once for each. Hence, the object of this study is the transcriptions of teacher talks from these six research subjects which were then analyzed using documentation techniques of data analysis namely selection, categorization, classification, identification, and verification. The results show that the lexical density used in elementary school teacher talk is 42.65% (low) and that one employed at the university level is 36.76% (low). Unexpectedly, the rate for elementary school is somewhat higher than that for the university level. This case appears to have an intervening aspect because the elementary school is an international school. It is learned that an educational institution—regardless of its level—with a distinct learning target would certainly influence the lexical density employed in the teachers’ spoken discourse during classes.
Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets
Authors: Brake Heather D. , Wilkins Melinda J. , Kaneene John B.
Published: March 2023

One of the important human health benefits of keeping pets may be to serve as an early warning system for indoor childhood exposure to toxic chemicals such as per- and polyfluoroalkyl substances (PFAS). The stain-resistant properties and environmental stability of PFAS make them a preferred choice for protective coatings and lubricants, and they have been used for years in various manufacturing and industrial processes around the world. Although the use of PFAS has arguably improved many commercial products, they have been linked to adverse health outcomes such as developmental delays, liver damage, immune suppression, disruption of endocrine and reproductive systems, and some cancers. The current body of literature suggests that serum PFAS levels in dogs and cats are analogous to their human counterparts and that household pets experience similar changes in blood chemistry markers. The proximity of small children and household pets to PFAS-treated carpets and floors, in addition to their tendency to put things into their mouths, potentially allows pets to serve as sentinels for household PFAS exposure. To assess the suitability of pets as indicators for exposure, researchers need to understand the most likely sources of PFAS exposure for household pets and identify the biomarkers of biological effects in those animals. Understanding these parameters may alert veterinary clinicians to potential sources of contamination in the home and ultimately protect the lives of the children and animals who live there.
The five-year KRAS, NRAS and BRAF analysis results and treatment patterns in daily clinical practice in Slovenia in 1st line treatment of metastatic colorectal (mCRC) patients with RAS wild-type tumour (wtRAS) – a real- life data report 2013–2018
Authors: Mesti Tanja , Rebersek Martina , Ocvirk Janja
Published: March 2023

Background

We preformed a Phase IV non-interventional study to assess KRAS, NRAS and BRAF status in metastatic colorectal cancer (mCRC) patients suitable for 1st line treatment and to evaluate the decisions for 1st line treatment considering the treatment goals in the RAS wild type (wt) patients. The aim of our study was also to evaluate the influence of a waiting period for biomarkers analysis on the start of first-line treatment.

Patients and methods

Patients with histologically confirmed mCRC adenocarcinoma suitable for first-line treatment fulfilling all inclusion criteria were included in the study. The KRAS, NRAS and BRAF analysis was performed from tissue samples of primary tumor site or metastatic site. All included patients have given consent to participate in the study by signing the informed consent form.

Results

From April 2013 to March 2018 at the Institute of Oncology Ljubljana 650 patients were included, 637 of them were treated with first- line systemic treatment according to RAS and BRAF status. Remaining 13 patients with mCRC did not receive systemic first-line treatment. The distribution of patients with KRAS mutated and wild-type tumors, was almost equal, 48.8% and 47.9% respectively, 89 % of the patients had wt NRAS tumours and 86.1% had wt BRAF tumours. The most frequently prescribed treatment was bevacizumab-based therapy (53.1%), either in combination with doublet chemotherapy or with mono-chemotherapy. EGFR inhibitors cetuximab and panitumumab were prescribed in wt RAS mCRC patients (30.9%). The waiting period for biomarkers analysis was two weeks.

Conclusions

Our real-world data, single centre 5-year analysis showed that the distribution between wild type and mutated type tumors of the patients with mCRC was approximately the same, as worldwide, so the Slovenian population with mCRC has the same ratio distribution of KRAS, NRAS and BRAF wild and mutated genes. We concluded that a two-week waiting period for biomarkers analysis did not influence the first line treatment decision, so it was in the accordance with the worldwide treatment guidelines based on evidence-based medicine.
Exploring the Philosophy and Forms of Traditional Balinese Architecture at Badung Market
Authors: Pranajaya I Kadek , Artayasa I Nyoman
Published: March 2023

After the fire disaster, Badung market was rebuilt by applying the values of Balinese  local wisdom. It was designed through an integrated synergy of regional arrangement within the Badung market, Kumbasari market, and the arrangement of the Tukad Badung to support the concept of a heritage city tour in Denpasar City. The philosophical concept used is tapak dara and padu raksa. The concept of values and architectural forms uses the Triangga, the Trimandala, the Sanga Mandala, and the Tri Hita Karana concepts. The forms of the entrance uses the bintang aring concept. It is combined with the kayon form as a symbol of balance, horizontal and vertical for human life. The concept of Balinese traditional architectural decoration uses bebadungan decorations. This research was with a qualitative exploratory method Researchers also found modernization towards more advanced changes with rational, effective, efficient, and economic principles. This is evidenced in the use ornaments made of Glass Reinforced Concrete, elevator facilities, and escalators. In addition, Badung market was designed to be more modern and universal with a children's play room, lactation room, emergency stairs, accessible toilets, and other facilities.Menjelajahi Filosofi dan Bentuk Arsitektur Tradisional Bali di Pasar Badung.  Pascabencana kebakaran, Pasar Badung dibangun dengan menerapkan nilai kearifan lokal Bali. Didesain melalui sinergitas penataan kawasan secara terpadu antara Pasar Badung, Pasar Kumbasari, dan penataan tukad Badung untuk menunjang konsep tur kota pusaka (heritage city tour) Kota Denpasar. Konsep filosofis yang digunakan adalah tapak dara sebagai simbol keseimbangan dan padu raksa sebagai makna stabilitas perputaran ekonomi masyarakat untuk peningkatan kesejahteraan. Konsep tata nilai dan bentuk bangunan menggunakan konsep triangga, trimandala, sanga mandala, dan tri hita karana. Bentuk pintu masuk pada bangunan utama menggunakan konsep bintang aring dengan bebatelan di kiri dan kanan. Bintang aring difilosofikan sebagai pintu yang bercahaya bagai bintang sehingga terlihat monumental, berestetika, dan menambah kesan oriental. Bintang aring dikombinasikan dengan bentuk kayon sebagai lambang keseimbangan, horisontal dan vertikal bagi kehidupan manusia. Konsep ragam hias arsitektur tradisional Bali menggunakan ragam hias bebadungan. Ragam hias ini didesain untuk menciptakan identitas jati diri Kota Denpasar. Peneliti juga menemukan kehidupan modernisasi dengan prinsip rasional, efektif, efisien, dan ekonomis. Hal ini dibuktikan pada penggunaan ornamen dari bahan Glass Reinforced Concrete (GRC), fasilitas elevator, dan eskalator. Selain itu Pasar Badung didesain lebih modern dan universal dengan adanya ruang bermain anak, ruang laktasi, tangga darurat, toilet aksesibel, dan fasilitas lainnya.
On the Protection of the Russian Diplomatic Property in Sweden
Authors: Plakhov Alexander V.
Published: March 2023

The decision of the Supreme Court of Sweden dated on 1st of July 2011 on the deprivation of State immunity of the Russian diplomatic property in Sweden is analyzed in the article. It provides a critical analysis of the legitimacy of the decision of the Supreme Court of Sweden on the basis of diplomatic correspondence, other documents and author’s personal participation in this case in the context of theories of state immunity and its property abroad, as well as the international treaties and customary international law and doctrine.
View on the History of International Relations and International Law in a Context of the Civilization Approach
Authors: Shumilov Vladimir M.
Published: March 2023

The author makes a brief view on the history of the international relations and international law in connection with stages/periods of development of international law. It is used theory and philosophy of civilization approach. On this basis the periodization of international law accepted by the Russian international legal doctrine is critically comprehended. The author exposes his subjective view on the role of the western civilization in the World order, and also on common part of international law as creation of the West.
Mergers and Acquisitions of Joint Stock Companies in Russia and Corporations in the US (legal regulation experience)
Authors: Kuzmin Stanislav E.
Published: March 2023

The procedure of merger and consolidation of joint stock companies in Russia is legislatively ﬁ xed in the Federal law «On joint stock companies». In the United States in each state the rules on mergers are adopted within the Corporation laws. The greatest interest represents the law of the state of Delaware. This procedure includes three steps. In Russia at the ﬁ rst stage the companies sign an agreement on merger or consolidation, and in the state of Delaware, the ﬁ rst step is the adoption by the Board of Directors of each participating corporation of a decision on approval of the agreement on merger or consolidation. At the second stage the boards of Directors of Russian joint stock companies bring to the decision of the General meeting of each participating company, the question of reorganization, on approval of the agreement on the merger. In the state of Delaware at the second stage of the General meeting of shareholders should approve or reject the transaction of merger or accession. The third stage both in Russia and in the state of Delaware, is registration of a new joint stock company, corporation, or registration of changes in society, corporation, in which another one has merged.
Prosastücke - Kleine Prosa - Der Spaziergang
Authors: Walser Robert
Published: March 2023

1917 veröffentlichte Robert Walser in drei verschiedenen Verlagen gleich drei neue Bücher: die Sammlung Prosastücke bei Rascher und Cie in Zürich, die Kleine Prosa bei Alexander Francke in Bern und die längere Erzählung Der Spaziergang im Verlag Huber und Co, Frauenfeld und Leipzig, in dem dann ein Jahr später auch das Poetenleben ( KWA I 9) erschien. Es handelt sich mehrheitlich um zuvor noch nicht gedruckte Texte; die wenigen Ausnahmen hat er so eingreifend bearbeitet, dass man von eigenständigen Fassungen sprechen kann. In neuer Weise setzt Walser sich in diesen Büchern mit Form und Inhalt seines Erzählens auseinander. Er variiert die poetologischen Mittel und die Möglichkeiten der Kleinen Form und sucht zugleich nach neuer schriftstellerischer Selbstverständigung. Im Hintergrund standen dabei die Rückkehr aus Berlin in die Schweiz und die Erfahrung und Beobachtung des Ersten Weltkriegs.
Leitmotivisch lässt sich die Beschäftigung mit Form und Tradition der Novelle verfolgen. Dies gilt nicht nur für die längere Erzählung Der Spaziergang, sondern auch für zahlreiche Texte der Sammlungen Prosastücke und Kleine Prosa. In Abgrenzung von den «Schwesterkünsten» Musik und Malerei richtet er sein Augenmerk auf die synästhetische Kraft der Poesie. Walser hat intensiv an diesen Texten, die er selbst als «teils ernster Teil heiterer Natur charakterisierte, gearbeitet. «Jedes einzelne Stück», schrieb er an den Rascher-Verlag, «ist mit starkem Fleiß und mit der sorgfältigsten Behutsamkeit geschrieben».
Post-Menopausal Quality of Life Claims: Overlooking the Requirements of Normal Science and Fundamental Measurement in ICER’S Cost-Effectiveness Assessment of Fezolinetant for Moderate to Severe Vasomotor Symptoms
Authors: Langley Paul C
Published: March 2023

One of the signal failures in health technology assessment is the absence of consideration given, not only to the standards of normal science, but to those of fundamental measurement. A recent evidence report by the Institute for Clinical and Economic Review (ICER) is emblematic of this failure. Based on a simple linear regression model that translates aggregate scores from the ordinal Menopause-specific Quality of Life Questionnaire (MENQOL) to the ordinal EuroQol EQ-5D-5L, ICER has applied these scores to an assumption driven model simulation to produce preferences, QALYs and incremental cost-per-QALY claims for fezolinetant for moderate to severe symptoms associated with menopause.  Unfortunately, the attempt to crosswalk multidimensional or multiattribute ordinal scores is mathematically impossible. The ‘created’ EQ-5D-5L preferences are, as a result, of no interest. The overall result is that the ICER modelled claims for cost-effectiveness fail the required standards for normal science and fundamental measurement. fundamental are impossible. This is unfortunate, although it might be possible to assess certain domains of the MENQOL for their approximation to an interval score with the application of the Rasch Rating Scale Model, this will not support quality of life claims. A preferred approach would be to consider an alternative latent trait for quality of life in menopause, applying Rasch Measurement Theory (RMT), to develop a polytomous instrument that has the required measurement properties. The purpose of this commentary is to point out, as a number of previous commentaries have done, that this framework for creating assumption driven simulated modelled claims has no role in decisions for product assessment, access to formulary and pricing. This commentary expands upon these previous commentaries in placing RMT is the context of a needed paradigm shift to support the evolution of objective knowledge. This is critical if we are to understand, from the individual’s perspective, not only an accurate assessment of the burden of menopause but to see this as part of an on-going research program that has to rely on fundamental measurement.
SOME ASPECTS OF EPIDEMIOLOGY, PATHOGENESIS, DIAGNOSIS AND TREATMENT OF MULTIPLE MYELOMA
Authors:   Department of Internal Medicine № 3, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, ABDULLAEVA S.N.
Published: March 2023

A literature review article provides a comprehensive overview of literature related to epidemiology, pathogenesis, diagnosis and treatment of multiple myeloma (MM). Literature data show that MM has unclear patterns of the disease distribution, and there are trends in rising incidence. Although the aetiology of MM is not fully understood, according to most researchers, risk factors (RFs) leading to a progressively high incidence of MM include advanced age, male gender, exposure to harmful environmental factors (ionising radiation, chemical agents), family predisposition, an increased prevalence of autoimmune diseases and obesity. MM is characterised by the absence of specific clinical manifestations and similarity with other conditions, which is one of the factors associated with delay in diagnosis of MM. Damage to internal organs, particularly the heart and kidneys, a frequent complication of MM, leads to mutual burdening and is also one of the factors of adverse outcomes early during the disease. The International Myeloma Working Group (IMWG) diagnostic criteria and additional investigation techniques allow high accuracy to diagnose MM and its complications. Despite the development and introduction of new drugs and treatments, the long-term survival rates in MM patient remains low. Therefore there is a need for further research in this direction. Keywords: Multiple myeloma, cardiorenal complications, diagnostics, free light chains of immunoglobulins, treatment.