bluuebunny/crossref_metadata_2025 huggingface dataset:
Resin Infiltration of Caries in Primary Molars in a Community Setting: 24-Month Randomized Controlled Trial Findings
Authors: Foster Page L.A. , Beckett D. , Ahmadi R. , Schwass D.R. , Leon de la Barra S. , Moffat S.M. , Meldrum A. , Thomson W.M.
Published: March 2017

This study aimed to assess whether resin infiltration of primary molar proximal lesions is more effective than noninvasive measures in radiographically controlling carious lesion progression into the dentin. A split-mouth randomized controlled trial included 90 children, each with 2 proximal lesions confined to the inner half of the enamel or ≤0.5 mm into the dentin. For each child, lesions were randomly allocated to test (infiltration: DMG Icon preproduct and fluoride varnish) or control (fluoride varnish) status. The primary outcome measure was 24-mo radiographic lesion progression. Placement of a restoration during the study period was counted as lesion progression. Proportions of teeth with progressed lesions were compared using the McNemar test. Children also reported on the treatment’s acceptability to them. Children (46% female) ranged in age from 6 to 9 y. Their mean number of decayed, missing, and filled teeth (d3mft) was 2.8 (SD 2.6). At baseline, 58% and 42% of children were at moderate and low risk, respectively. Test and control lesions presented with similar radiographic lesions at baseline. At the 24-mo follow-up, 6 children had moved and 30 teeth had exfoliated. In the test and control groups, 15 of 66 lesions (22.7%) and 30 of 69 lesions (43.5%) had progressed, respectively (P < 0.05). The 2-y therapeutic effect (based on pairwise radiographic readings) of infiltration over fluoride varnish was 20.8% (95% confidence interval, 10.6%−30.2%). Nearly all children (96.7%) had enjoyed their visit to the clinic, and more than two-thirds (72.2%) were not worried about returning for treatment. Infiltration is more efficacious than fluoride varnish for controlling carious lesion progression in proximal lesions in primary molars, and most children find the treatment acceptable (Australian New Zealand Clinical Trials Registry ANZCTR.org.au ACTRN12611000827932).

Knowledge Transfer Statement: These study findings can help clinicians decide which caries management approach they wish to use to prevent progression of proximal lesions in primary molars. With consideration of cost and patient preference, this information could lead to more appropriate therapeutic decisions.
Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer
Authors: Bardia Aditya , Mayer Ingrid A. , Diamond Jennifer R. , Moroose Rebecca L. , Isakoff Steven J. , Starodub Alexander N. , Shah Nikita C. , O’Shaughnessy Joyce , Kalinsky Kevin , Guarino Michael , Abramson Vandana , Juric Dejan , Tolaney Sara M. , Berlin Jordan , Messersmith Wells A. , Ocean Allyson J. , Wegener William A. , Maliakal Pius , Sharkey Robert M. , Govindan Serengulam V. , Goldenberg David M. , Vahdat Linda T.
Published: March 2017

Purpose

Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan.

Patients and Methods

We evaluated sacituzumab govitecan in a single-arm, multicenter trial in patients with relapsed/refractory metastatic TNBC who received a 10 mg/kg starting dose on days 1 and 8 of 21-day repeated cycles. The primary end points were safety and objective response rate; secondary end points were progression-free survival and overall survival.

Results

In 69 patients who received a median of five prior therapies (range, one to 12) since diagnosis, the confirmed objective response rate was 30% (partial response, n = 19; complete response, n = 2), the median response duration was 8.9 (95% CI, 6.1 to 11.3) months, and the clinical benefit rate (complete response + partial response + stable disease ≥ 6 months) was 46%. These responses occurred early, with a median onset of 1.9 months. Median progression-free survival was 6.0 (95% CI, 5.0 to 7.3) months, and median overall survival was 16.6 (95% CI, 11.1 to 20.6) months. Grade ≥ 3 adverse events included neutropenia (39%), leukopenia (16%), anemia (14%), and diarrhea (13%); the incidence of febrile neutropenia was 7%. The majority of archival tumor specimens (88%) were moderately to strongly positive for Trop-2 by immunohistochemistry. No neutralizing antibodies to the ADC or antibody were detected, despite repeated cycles developed.

Conclusion

Sacituzumab govitecan was well tolerated and induced early and durable responses in heavily pretreated patients with metastatic TNBC. As a therapeutic target and predictive biomarker, Trop-2 warrants further research.
A Paper Mirror: Autobiographical Moments in Modern Chinese Poetry
Authors: Wu Shengqing
Published: March 2017

Through the examination of a select body of classical-style poems that are inscribed on or written about photographs of the self in the modern era, this article delves into the intertwined issues of the self, affect, and autobiographical writing. It first explores the ethical implications of “poems on photographs of the self” (ziti xiaozhao 自題小照) and the issue of temporality involved in the confrontation with a self-image and subsequent writing about the image. Second, it focuses on the issue of the self as other, as well as fractures and the instability of modern subjectivity as amplified in visual self-encounters. In so doing, the article attempts to offer a new understanding of the self/image and text/image dynamic, with insight into the cultural and affective articulations of the self in the context of a new visual culture in modern China.
Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal
Authors: Ye Shoudong , Zhang Tao , Tong Chang , Zhou Xingliang , He Kan , Ban Qian , Liu Dahai , Ying Qi-Long
Published: March 2017

Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-mediated repression of the pluripotency network. How inhibition of MEK mediates ESC self-renewal, however, remains largely unknown. Here, we show that inhibition of MEK can significantly suppress lymphoid enhancer factor 1 (LEF1) expression in mouse ESCs. Knockdown or knockout of Lef1 partially mimics the self-renewal promoting effect of MEK inhibitors. Moreover, depletion of both Tcf3 and Lef1 enables maintenance of undifferentiated mouse ESCs without exogenous factors, cytokines, or inhibitors. Transcriptome resequencing analysis reveals that LEF1 is closely associated with endoderm specification in ESCs. Thus our study adds support to the notion that the key to maintaining the ESC ground state is to shield ESCs from differentiative cues.
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Authors: Martín-Ibáñez Raquel , Pardo Mónica , Giralt Albert , Miguez Andrés , Guardia Inés , Marion-Poll Lucile , Herranz Cristina , Esgleas Miriam , Garcia-Díaz Barriga Gerardo , Edel Michael J. , Vicario-Abejón Carlos , Alberch Jordi , Girault Jean-Antoine , Chan Susan , Kastner Philippe , Canals Josep M.
Published: March 2017

Here, we unravel the mechanism of action of the Ikaros family zinc finger protein Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons, which express dopamine 2 receptor and enkephalin. To exert this effect, He is expressed in neural progenitor cells (NPCs) keeping them in the G1/G0 phase of the cell cycle. Thus, a lack of He results in an increase of S-phase entry and S-phase length of NPCs, which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ), which end up dying at postnatal stages. Therefore, He−/− mice show a reduction in the number of dorso-medial striatal MSNs in the adult that produces deficits in motor skills acquisition. In addition, overexpression of He in NPCs induces misexpression of DARPP-32 when transplanted in mouse striatum. These findings demonstrate that He is involved in the correct development of a subset of striatopallidal MSNs and reveal new cellular mechanisms for neuronal development.
Translational applications of adult stem cell-derived organoids
Authors: Drost Jarno , Clevers Hans
Published: March 2017

Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in in vitro disease modeling, personalized cancer therapy and regenerative medicine.
Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis
Authors: Simunovic Mijo , Brivanlou Ali H.
Published: March 2017

Cells have an intrinsic ability to self-assemble and self-organize into complex and functional tissues and organs. By taking advantage of this ability, embryoids, organoids and gastruloids have recently been generated in vitro, providing a unique opportunity to explore complex embryological events in a detailed and highly quantitative manner. Here, we examine how such approaches are being used to answer fundamental questions in embryology, such as how cells self-organize and assemble, how the embryo breaks symmetry, and what controls timing and size in development. We also highlight how further improvements to these exciting technologies, based on the development of quantitative platforms to precisely follow and measure subcellular and molecular events, are paving the way for a more complete understanding of the complex events that help build the human embryo.
The chromatin modifier Satb1 regulates cell fate through Fgf signalling in the early mouse embryo
Authors: Goolam Mubeen , Zernicka-Goetz Magdalena
Published: March 2017

The separation of embryonic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which will form the new organism, from the primitive endoderm (PE), which will form the yolk sac, is a crucial developmental decision. Here, we identify a chromatin modifier, Satb1, with a distinct role in this decision. Satb1 is differentially expressed within 16-cell-stage embryos, with higher expression levels in the inner cell mass progenitor cells. Depleting Satb1 increases the number of EPI cells at the expense of PE. This phenotype can be rescued by simultaneous depletion of both Satb1 and Satb2, owing to their antagonistic effect on the pluripotency regulator Nanog. Consequently, increasing Satb1 expression leads to differentiation into PE and a decrease in EPI, as a result of the modulation of expression of several pluripotency- and differentiation-related genes by Satb1. Finally, we show that Satb1 is a downstream target of the Fgf signalling pathway, linking chromatin modification and Fgf signalling. Together, these results identify a role for Satb1 in the lineage choice between pluripotency and differentiation and further our understanding of early embryonic lineage segregation.
BRC1expression regulates bud activation potential, but is not necessary or sufficient for bud growth inhibition in Arabidopsis
Authors: Seale Madeleine , Bennett Tom , Leyser Ottoline
Published: March 2017

The degree of shoot branching in Arabidopsis is determined by the activation of axillary buds. Bud activity is regulated by diverse environmental and developmental signals, often mediated via plant hormones including auxin, strigolactone and cytokinin. The transcription factor, BRANCHED1 (BRC1), has been proposed to integrate these regulatory signals. This idea is based on increased branching in brc1 mutants, the effects of bud-regulating hormones on BRC1 expression, and a general correlation between BRC1 expression and bud growth inhibition. These data demonstrate the important role of BRC1 in shoot branching, but here we show that in Arabidopsis this correlation can be broken. Buds lacking BRC1 expression can remain inhibited and sensitive to inhibition by strigolactone. Furthermore, buds with high BRC1 transcript levels can be active. Based on these data, we propose that BRC1 regulates bud activation potential in concert with an auxin-transport based mechanism underpinning bud activity. In the context of strigolactone-mediated bud regulation, our data suggest a coherent feed-forward loop in which strigolactone treatment reduces the probability of bud activation by parallel effects on BRC1 transcription and the shoot auxin transport network.
U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem–loop binding protein
Authors: Skrajna Aleksandra , Yang Xiao-cui , Bucholc Katarzyna , Zhang Jun , Hall Traci M. Tanaka , Dadlez Michał , Marzluff William F. , Dominski Zbigniew
Published: March 2017

Cleavage of histone pre-mRNAs at the 3′ end requires stem–loop binding protein (SLBP) and U7 snRNP that consists of U7 snRNA and a unique Sm ring containing two U7-specific proteins: Lsm10 and Lsm11. Lsm11 interacts with FLASH and together they bring a subset of polyadenylation factors to U7 snRNP, including the CPSF73 endonuclease that cleaves histone pre-mRNA. SLBP binds to a conserved stem–loop structure upstream of the cleavage site and acts by promoting an interaction between the U7 snRNP and a sequence element located downstream from the cleavage site. We show that both human and Drosophila SLBPs stabilize U7 snRNP on histone pre-mRNA via two regions that are not directly involved in recognizing the stem–loop structure: helix B of the RNA binding domain and the C-terminal region that follows the RNA binding domain. Stabilization of U7 snRNP binding to histone pre-mRNA by SLBP requires FLASH but not the polyadenylation factors. Thus, FLASH plays two roles in 3′ end processing of histone pre-mRNAs: It interacts with Lsm11 to form a docking platform for the polyadenylation factors, and it cooperates with SLBP to recruit U7 snRNP to histone pre-mRNA.
Achieving good adherence to inhaled corticosteroids after weighing canisters of asthmatic children
Authors: Chuenjit Wantida , Engchuan Vorapan , Yuenyongviwat Araya , Sangsupawanich Pasuree
Published: March 2017

Background: The metered-dose inhalers (MDIs) currently available for inhaled corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the integration of regular weighing of the canisters into the routine service. Methods: A cohort study was carried out between May 2013 and April 2014. Children aged less than 8 years with a diagnosis of asthma were recruited. The duration of adherence assessment was 24 weeks. Participants had a regular schedule every 8 weeks to obtain a new FLIXOTIDE® 125 inhaler. Parents were asked to collect the discarded MDI canisters, which were then weighed by a laboratory scale. The weight of each canister was replaced in the regression equation to calculate the number of doses actuated from the MDIs. Results: A total of 52 asthmatic children participated in the study. The median age was 52.7 months. At the end of 24 weeks, 44, 33, and 23 discarded MDI canisters were collected from visits 1, 2, and 3, respectively. The median percentages of adherence were 96.8%, 96.3%, and 96.3%, respectively. In 11 discarded canisters (11%), the remaining medication was more than 30% of the labeled doses. Approximately 90% of the participants had no asthma exacerbation during 24-week study period. Conclusion: High adherence rates were achieved after integration of canister weighing into the asthma care service.
Case Report: Intramammary lymph node metastasis of an unknown primary, probably occult breast, undifferentiated carcinoma
Authors: Sidiropoulou Zacharoula , Adélia Félix , Gil Isabela , Teles Tobias , Santos Claudia , Monteiro Lucilia
Published: March 2017

Little is known about the clinical importance of intramammary lymph node metastasis of breast cancer, even though it is not rare. In the present paper, the authors present an unusual, rare case of an intramammary lymph node metastasis of an unknown primary, probably occult breast cancer, and its management. The patient was submitted to various staging exams and surgical procedures and a definitive diagnosis was not established. From a multidisciplinary context, it was assumed that the patient had a breast triple negative primary with axillary involvement. This decision lead to adjuvant chemo and radiotherapy. Challenging cases like the one described here, should always be managed within the multidisciplinary team context and recorded in the institution’s database.
Case Report: Sciatic nerve schwannoma - a rare cause of sciatica
Authors: Munakomi Sunil , Shrestha Pratyush
Published: March 2017

Herein we report a rare case of a sciatic nerve schwannoma causing sciatica in a 69-year-old female. Sciatic nerve schwannoma is a rare entity. It should always be considered as a possible cause of sciatica in patients that present with symptoms of sciatica with no prolapsed disc in the lumbar spine and a negative crossed straight leg raise test. Timely diagnosis and complete excision of the lesion leads to complete resolution of the symptoms of such patients.
Tendencies of Development of Foreign Investment in the World Market of Services of the Industrial Construction
Authors: Смирнов  , Smirnov E.
Published: March 2017

Basic and functional priorities of innovative development of our country should be estimated and considered,

first of all, in the context of its cooperation with the European Union (EU) which is our main external economic

partner. It is caused by a complex of historical, economic, geographical, cultural and political factors and

regularities. However progressive approaches of developed countries to forming of the national innovative

systems (NIS) are also important from the point of view of their use for the solution of the same problems

in Russia. Forming of mechanisms of interstate regulation of innovative development at the level of the

Eurasian Economic Union (EEU) shall consider: orientation to broad support of the basic and improving

innovations, a combination of state regulation and a market mechanism in development of the innovative

sphere, assistance to the international investment cooperation and a transfer of technologies, protection of

interests of an innovative entrepreneurship, social aspects of orientation of interstate innovative policy. In

the article the problems of development of an innovative cooperation at the level of EEU in the context of

creation of effective integration consolidation are analyzed and generalized.
Occupational Incidence of Employees of Enterprises State Corporation "Rosatom"
Authors: Немков  , Nemkov A. , Афонин  , Afonin S. , Антоненков  , Antonenkov A. , Калинина  , Kalinina M. , Бушманов  , Bushmanov Andrey , Туков  , Tukov A. , Гурьев  , Gurev A. , Уйба  , Uyba V. , Капитонова  , Kapitonova N.
Published: March 2017

Purpose: To analyze the incidence of occupational diseases of employees of factories and organizations in State Corporation «Rosatom».

Material and methods: The study was conducted with the use of primary documents, containing information about the diseases and working conditions in the workplace. The calculation of this indicator is based on the standard and original software.

Results: In 2014 leading position among professional pathologies adhesive capsulitis of the shoulder (26.1 %), a number enthesopathies (13.4 %), lateral and medial epicondylitis (4.2 % and 0.8 %, respectively) occupy. Pathologies associated with decrease in hearing (9.2 %). Cancers of the respiratory system, as well as malignant neoplasms unspecified localization (5.9 %). In the structure of occupational diseases employees from 50 to 59 years (36.9 %) is dominated; the lowest level of occupational diseases in the group under 39 years (5.9 %). 68.9 % of employees , registered in 2014, were over the age of 50. For the 2010–2014 long-term dynamics of occupational diseases shows its growth from 1.6 cases per 10,000 employees (2010) to 4.5 cases per 10,000 employees (2014). The negative long-term dynamics (2010–2014) observed for occupational diseases of the musculoskeletal system and connective tissue (from 0.1 to 2.57 cases per 10,000 employees), vibration disease (from 0.7 to 0.9 cases per 10,000 employees), malignant neoplasms (from 0.2 to 4.2 cases per 100,000 employees).

Conclusion: During 2010–2014 there was an increase of the incidence, mainly due to professional pathology of the musculoskeletal system and connective tissue, cases of vibration disease and malignant neoplasms. The highest morbidity rate of professional diseases was observed in workers of Priargunsky Industrial Mining and Chemical Union.Analysis of the data showed that the greatest number of diseases was revealed at persons in the age range 50–59 years old.
To Improve Accuracy of Radionuclide Therapy Dosimetry Planning Using Monte Carlo Method
Authors: Наркевич  , Narkevich B. , Гончаров  , Goncharov M. , Лысак  , Lysak Yu. , Ширяев  , Shiryaev S.
Published: March 2017

Purpose: Development and clinical testing of methodology dosimetry planning of radionuclide therapy based on Monte Carlo simulation of radiation transfer process.

Material and methods: The method of determination in absolute units of radiopharmaceutical (RP) activity accumulated in tumor lesions. The technique is based on scintigraphy syringe containing diagnostic RP activity, biplane patient scintigraphy after injection of the RP and determination of the RP accumulation when administered calculated using the Monte Carlo method for the absorption and scattering of radiation in the patient’s body and in the collimator of the gamma camera. Code MCNP Monte Carlo simulation was used. The layout of determination of the value of accumulated RP activity in the patient’s tumor site implies successive implementation of the following three steps.

1. Scintigraphic images are obtained of the vial containing already known activity of the RP placed at the fixed source-to-collimator distance, following

which estimation of the detector count rate within the specified region of interest of the vial image is undertaken.

2. Therapeutic activity A0 is introduced in the patient’s body, scintigraphic examination of the patient is performed. Estimation of the detector count rate in the region where the tumor is located and the value of tissue background in the close enough vicinity to the tumor is performed using the tools for contouring the region of interest on the obtained planar image provided using the software imbedded in the scintigraphic equipment.

3. Value of accumulated activity RP in the affected tumor is determined according to the correction factor which is calculated using Monte-Carlo method for specific clinical case for the geometry used in obtaining scintigraphic images which is identical to the conditions of measurement of activity in the vial and in the patient’s body. The technique has been tested in the study, with an injection of 30 MBq of 123I-MIBG child with neuroblastoma.

Results: The level of accumulation of radiopharmaceutical in the tumor of the adrenal gland was 0.78 MBq, i.e. 2.6 % of the administered activity. This corresponds to literature data (average about 2.4 %) for scintigraphic studies of children with neuroblastomas. When using the known calculation method for analytical formula without the introduction of corrections for the absorption and scattering of radiation was obtained a result of 1.02 MBq, i.e. overestimation was 31 %.

Conclusions: Introduction calculated by the Monte Carlo method for the absorption and scattering of radiation during scintigraphy patient can improve the accuracy of dosimetry planning of radionuclide therapy.
Future focused finance: Transforming the NHS finance profession
Authors: Minogue Virginia , Ellcock David
Published: March 2017

Aims:

To outline the progress of a change programme aimed at supporting and transforming the NHS finance profession to meet the challenges of new models of healthcare delivery.

Methods:

A review of the Future Focused Finance (FFF) programme was undertaken between May and August 2016. It involved scoping and mapping of activity, qualitative data collection using surveys and interviews, and a review of social media activity.

Results:

The review found that in the first two years, the FFF programme had become a recognisable brand successfully launching the concept of FFF, embedding the brand and highlighting important issues relating to finance. The programme had developed with the support of a small central team and the discretionary/voluntary contributions of many other NHS staff engaging in the work of the six action areas.

Conclusion:

Change programmes can be challenging to maintain and sustain without high level drive and ownership and resources to ensure implementation. Dissemination plans are a critical part of ensuring outputs are implemented. The FFF programme is the first NHS change programme to address the specific needs of the finance profession and to focus on developing the relationship with clinical services to improve patient outcomes.
Using consensus group methods to improve simulation using immersive media in paramedicine
Authors: Barr Nigel , Foster Julie-Anne
Published: March 2017

Problem:

Simulation is a cornerstone of paramedic pedagogy. It facilitates a learning-centred approach which explicitly links the learning and teaching environment to the real world and enables the student to construct new understandings of paramedic practice threshold concepts. Although the benefits of simulation in medical and health education have been well researched, there is a paucity of research into how to deliver simulation using immersive media (IM) due to its recency as a strategy in paramedicine. This study explored student feedback of simulations using IM to improve the efficacy of learning activities designed for the recently commissioned University of the Sunshine Coast (USC) immersive simulation studio.

Method:

Feedback was taken using a modified Nominal Group Technique (NGT) consensus method post implementation of an IM strategy. Participants were second year students of the Bachelor of Paramedic Science program at USC who had undertaken simulation using immersive media in 2015.

Results:

The research has revealed the value of listening to the student voice in enhancing simulation design. Two major themes arose regarding the value of IM according to students. Firstly, the students perceived that benefits were derived from the closer approximation of an authentic practice environment through the use of immersive media. Secondly, that students felt that the immersive style allowed them to practice of a broader range of technical and non-technical skills than in a conventional classroom.

Conclusion:

IM was perceived as a positive experience by students as they reported IM to be more engaging, increasing their confidence, situational awareness and improved their non-technical skills. The USC paramedic program will continue to develop the IM strategy as a signature pedagogy.
The girl and the ghost
Authors: Fikse Per , Larsen Endre Eidsaa
Published: March 2017

By guiding our attention to the emotional responses of a little girl and her darkly lit surroundings, Jude’s film explores human existence in the face of death. Informed by existential philosophy in the vein of Heidegger, this article investigates the difference between fear of death and fear of the dead.
The invisible stalker in It Can Pass Through the Wall
Authors: Mišeljić Jelena
Published: March 2017

A patient and somewhat disturbing camera in Jude’s film turns the coming-of-age tale into a ghost story. Is the innocent girl, surrounded by drunk and indifferent old men-children, aware of this ‘other presence’? As ‘seeing’ is one of the basic themes in this film, this article will analyse its intrusive and seductive point of view.
Who wears The Jacket?
Authors: Maggio Rodolfo
Published: March 2017

Paul and Kaya journey through three dimensions of reciprocity: the World, the pub and their ‘world’. The unmaking of their relationship suggests an underlying confrontation between incompatible gendered values. This might be interpreted as a reflection of current anthropological changes in Austria, particularly in the meaning of masculinity and femininity.
The Jacket: A love story turned inside out
Authors: Felando Cynthia
Published: March 2017

This article argues that The Jacket is a testament to one of the short film’s preferences: a resistance to narratives that involve love and romance – or at least happilyever-after endings. This is also one of the ways in which short and feature-length film storytelling generally differ.
Izkušnje medicinskih sester v patronažnem varstvu z obiski na domu v okviru projekta Nadgrajena celovita obravnava pacienta: rezultati pilotne raziskave
Authors: Ramšak Pajk Jožica , Benkovič Robertina , Poplas Susič Tonka
Published: March 2017

Uvod: Patronažno zdravstveno varstvo je pomemben člen pri odkrivanju, spremljanju in obravnavi kroničnih bolezni na primarni ravni. Namen raziskave je bil predstaviti izkušnje in stališča do nadgrajene preventivne obravnave ter obiskov na domu.

Metode: Uporabljen je bil mešani raziskovalni dizajn. Podatki so bili zbrani z delno strukturiranim vprašalnikom (Cronbach α = 0,92). Sodelovalo je 50 diplomiranih medicinskih sester, odzivnost je bila 81-% (n = 41). Opravljena je bila tematska analiza odprtih vprašanj. Za kvantitativne podatke je bila uporabljena opisna statistika, t-test, analiza variance in korelacijska analiza.

Rezultati: Prispevek preventivnih obiskov na domu anketiranci vidijo v zdravstvenovzgojnem delovanju (x = 4,34, s = 0,85), odkrivanju rizičnih dejavnikov (x = 4,12, s = 0,81) in ohranjanju kakovosti življenja pacientov ( x= 4,10, s = 0,92). Zadovoljstvo anketirancev je povezano s sprejemanjem obiskov s strani pacientov in družin (r = 0,754, p < 0,001), s prispevkom k stroki patronažnega varstva (r = 0,766, p < 0,001) ter z obravnavo posameznika z družino (r = 0,693, p < 0,001). V tematski analizi sta bili identificirani dve temi, in sicer (1) pozitivne izkušnje z obiski in (2) negativne izkušnje z obiski.

Diskusija in zaključek: Novo obliko preventivnih patronažnih obiskov v domačem okolju anketirani podpirajo, še posebej možnost celovite obravnave posameznika in njegove družine. Glede na ugotovitve se predlaga, da medicinska sestra v patronažnem varstvu postane enakovreden partner v timu referenčne ambulante na nacionalnem nivoju.
KETERPENJARAAN TOKOH PEREMPUAN DALAM CERPEN THE YELLOW WALLPAPER KARYA CHARLOTTE PERKINS GILMAN
Authors: Asmarani Ratna
Published: March 2017

The purpose of this paper is to analyse the problems around the imprisonment of the female protagonist in Chalotte Perkins Gilman’s short story entiled The Yellow Wallpaper. The focus of the analysis is on the actors and factors causing imprisonment, types dan impacts of imprisonment, efforts to overcome the imprisonment, and the end of the imprisonment experienced by the female protagonist. To analyse this problems, feminist literary criticism is used supported by the stereotypes of the nineteenth century women, the medical opinion at that time and the feminist perspective concerning the mental disorder experienced by women, and the concept of oppression in the imprisonment as well. The result shows that a woman who experiences the physical and psychological imprisonment in the patriarchal household area tends to have mental disorder as an alternative to gain freedom. The conclusion that can be drawn is that in the patriarchal environment women’s movement area and psychological, emotional, intellectual actualization  tend to be limited in which the women who fight against those linitations will get the stigma of suffering from mental illness.
APA DAN MANA DALAM KALIMAT DEKLARATIF
Authors: Astuti Sri Puji
Published: March 2017

Kalimat merupakan salah satu sarana untuk menyampaikan maksud pembicara atau penulis kepada pendengar atau pembaca. Untuk menyampaikan informasi digunakan kalimat deklaratif. Dalam kalimat deklaratif sering ditemui kata apa dan mana serta bentuk turunannya. Bagaimana kehadiran apa dan mana serta bentuk turunannya dalam kalimat deklaratif dibahas dalam makalah ini. Teori yang digunakan untuk menganalisis adalah teori stuktural. Pengumpulan data dilakukan dengan cara menyimak pemakaian bahasa. Dalam analisis data digunakan metode distribusional yaitu metode analisis data yang berupa penghubungan aantarfenomena dalam bahasa tertentu itu sendiri  Adapun teknik yang d.igunakan dalam penelitian ini adalah teknik delisi, substitusi, dan teknik parafrasa. Dari hasil penelitian disimpilkan  bahwa apa dan mana serta bentuk tuturannya jika terdapat dalam kalimat deklaratif bukan merupakan interogativa. Kehadiran apa dan mana serta bentuk tuturannya dalam kalimat deklaratif ada yang bersifat wajib ada yang bersifat opsional. Apa dan mana serta bentuk turunannya  bersifat opsional jika dalam kalimat deklaratif apa dan mana serta bentuk tuturannya diikuti atau didahului oleh kata yang mempunyai makna yang sama
HOMOSOSIALITAS DI PONDOK PESANTREN: STUDI KASUS DI PONDOK PESANTREN AS-SAKAN
Authors: Sudrajat Nur Gian Nova , Priyatna Aquarini , Zakaria Mumuh Muhsin
Published: March 2017

This paper discusses the homosexual practices among students at Pondok Pesantren As-Sakan. By using queer and homosociality theory, the paper will show that human sexuality is a very complex continuum, in which homosexual practices can be manifested in various forms. It will be shown that same-sex relationships are built on male friendship patterns among men, mentorship, entilement, competition between homosexuality and heterosexuality in intimate relationships so that there is a shift in the relationship in it. The practice of sex segregation which is part of the normative practice of the boarding school, manifested in, for example, activities, rules and sanctions, as well as facilities and infrastructure of the school, can be argued to have engendered practices that can be categorized as homosexual practices.
Policy Watch: The Consumer Financial Protection Bureau's Consumer Research: Mission Accomplished?
Authors: Horn Richard
Published: March 2017

This article introduces readers to the Consumer Financial Protection Bureau (CFPB), a federal agency created under the Dodd–Frank Act to protect consumers of financial services and products. The CFPB has an important mission to ensure consumers have clear and timely information about consumer financial products and services in the marketplace so they can make the best decisions for themselves, as well as to foster competition and prevent unfair, deceptive, or abusive acts or practices. This article discusses some of the CFPB's rulemakings and other initiatives to achieve this transparency for consumers and questions whether the agency has conducted sufficient consumer research. The article suggests ways in which the CFPB could improve its work. Finally, the article briefly addresses how academic research may be able to assist the CFPB with its mission.
Differences in regional development on the territory of the Republic of Serbia
Authors: Živanović Zora , Gatarić Dragica R.
Published: March 2017

Unbalanced regional development is one of the basic characteristics of the regional development of the Republic of Serbia. The aim of the paper is to highlight the proportions of unbalanced regional development of Serbia by positioning regions in accordance with the values of the indicators included in the survey: population density, (un)employment (the number of employed people per 1,000 inhabitants), activity structure and the amount of average income per employee. The indicators presented in the paper emphasize the role of certain regions in the current regional reality of Serbia. Also, they exemplify regional disparities more comprehensively in terms of the achieved level of socio-economic development and the orientation of the analysed regions to particular sectors of the economy.
Gender Trouble in Conan Doyle’s “The Adventure of the Solitary Cyclist”
Authors: Kitsi-Mitakou Katerina
Published: March 2017

Although the Victorian period was a time when the sexes were assigned distinct and complementary roles, these rigid gender-role divisions between the two sexes were beginning to dissolve as the nineteenth century was drawing to its close. Among the various factors that contributed to bringing the two genders closer was the cycling boom of the 1890s, and the first-wave feminists embraced the bicycle as a freedom machine and symbol of emancipation. Despite the fact, though, that cycling functioned at first as a gender equaliser, , it eventually segregated the sexes, as social norms promoted the idea of gendered cycling and enforced a model of domesticated or feminised cycling for women. This essay aims to explore how Arthur Conan Doyle’s 1895 story “The Adventure of the Solitary Cyclist” reflects this complicated impact that cycling had on gender segregation and the possibilities it offered for gender fusion as well as the alternative expressions of sexuality it enabled.
Theorising Public and Private Spheres
Authors: Sima Remina
Published: March 2017

The 19th century saw an expression of women’s ardent desire for freedom, emancipation and assertion in the public space. Women hardly managed to assert themselves at all in the public sphere, as any deviation from their traditional role was seen as unnatural. The human soul knows no gender distinctions, so we can say that women face the same desire for fulfillment as men do. Today, women are more and more encouraged to develop their skills by undertaking activities within the public space that are different from those that form part of traditional domestic chores. The woman of the 19th century felt the need to be useful to society, to make her contribution visible in a variety of domains. A woman does not have to become masculine to get power. If she is successful in any important job, this does not mean that she thinks like a man, but that she thinks like a woman. Women have broken through the walls that cut them off from public life, activity and ambition. There are no hindrances that can prevent women from taking their place in society.
Pop Feminism: Televised Superheroines from the 1990s to the 2010s
Authors: Bercuci Loredana
Published: March 2017

This paper analyses the construction of two superheroines, one from the 1990s (Buffy the Vampire Slayer) and one from the 2010s (Jessica Jones). I contend that popular feminism has changed between the 1990s and the present and that this is evident in the representation of televised superheroines. While in the 1990s superheroines were more conformist, today they are more transparent in their feminist intentions. I suggest that this is due to contemporary cultural trends in the United States.
Hall Effects on Isothermal Vertical Plate with Uniform Mass Diffusion in the Presence of Rotating Fluid and Chemical Reaction of First Order
Authors: Dhananjeya Kumaar V.S.A. , Muthucumaraswamy R.
Published: March 2017

An exact solution of the combined study of Hall effects on a vertical plate with a rotating fluid in the presence of a homogeneous chemical reaction of first order has been analysed. The dimensionless governing coupled partial differential equations are tackled using the usual Laplace transform technique. The sway of the Hall parameter, Hartmann number, Grashof number, Prandtl number, Schmidt number, chemical reaction parameter on the axial velocity and concentration of the fluid has been depicted graphically. When the non-dimensional angular velocity, Ω=2M21+m.2$\Omega = {{{\it 2}M^2 } \over { {\it 1} + m.^{2} }}$, the transverse velocity component vanishes, thereby the axial velocity of the fluid attains the maximum value. It is noted that with increase in the Hall parameter, thermal Grashof number and mass Grashof number, the axial velocity of the fluid increases significantly.
Mixed Convective Fully Developed Flow in a Vertical Channel in the Presence of Thermal Radiation and Viscous Dissipation
Authors: Prasad K.V. , Mallikarjun P. , Vaidya H.
Published: March 2017

The effect of thermal radiation and viscous dissipation on a combined free and forced convective flow in a vertical channel is investigated for a fully developed flow regime. Boussinesq and Roseseland approximations are considered in the modeling of the conduction radiation heat transfer with thermal boundary conditions (isothermal-thermal, isoflux-thermal, and isothermal-flux). The coupled nonlinear governing equations are also solved analytically using the Differential Transform Method (DTM) and regular perturbation method (PM). The results are analyzed graphically for various governing parameters such as the mixed convection parameter, radiation parameter, Brinkman number and perturbation parameter for equal and different wall temperatures. It is found that the viscous dissipation enhances the flow reversal in the case of a downward flow while it counters the flow in the case of an upward flow. A comparison of the Differential Transform Method (DTM) and regular perturbation method (PM) methods shows the versatility of the Differential Transform Method (DTM). The skin friction and the wall temperature gradient are presented for different values of the physical parameters and the salient features are analyzed.
Graphene growth by transfer-free chemical vapour deposition on a cobalt layer
Authors: Macháč Petr , Hejna Ondřej , Slepička Petr
Published: March 2017

The contribution deals with the preparation of graphene films by a transfer-free chemical vapour deposition process utilizing a thin cobalt layer. This method allows growing graphene directly on a dielectric substrate. The process was carried out in a cold-wall reactor with methane as carbon precursor. We managed to prepare bilayer graphene. The best results were obtained for a structure with a cobalt layer with a thickness of 50 nm. The quality of prepared graphene films and of the number of graphene layers were estimated using Raman spectroscopy. with a minimal dots diameter of 180 nm and spacing of 1000 nm were successfully developed.
Universal Optimization Efficiency for Nonlinear Irreversible Heat Engines
Authors: Zhang Yanchao , Guo Juncheng , Lin Guoxing , Chen Jincan
Published: March 2017

We introduce a multi-parameter combined objective function of heat engines under the strong coupling and symmetry condition and derive the universal expression of the optimization efficiency. The results obtained show that the optimization efficiency derived from the multi-parameter combined objective function include a variety of optimization efficiencies, such as the efficiency at the maximum power, efficiency at the maximum efficiency-power state, efficiency at the maximum ecological or unified trade-off function, and Carnot efficiency. It is further explained that these results are also suitable for the endoreversible cycle model of the Carnot heat engines operating between two heat reservoirs.
A critical review of literature on English language teaching textbook evaluation: What systemic functional linguistics can offer
Authors: Zhang Xiaodong
Published: March 2017

This paper, from the perspective of language learning as a meaning-making process, presents a critical review of the existing research on how pre-use, in-use, and post-use evaluation has investigated the relationship between English language teaching textbooks’ content and learners’ academic literacy development. The paper shows that previous research on these three types of evaluation examined English language teaching textbooks’ effect on English learners’ academic literacy development in an unprincipled and macro way. The research gap identified in these previous studies calls for an improved textbook evaluation framework that integrates a principled learning theory while simultaneously emphasizing macro-constructs (e.g., context) and micro-linguistic features needed for academic literacy development. To this end, this paper proposes a framework informed by Systemic Functional Linguistics-related constructs (e.g., genre, register, meta-meanings, and lexico-grammar system) to optimize the evaluation of English language teaching textbook content.
Negotiation of identities in intercultural communication
Authors: Janík Zdeněk
Published: March 2017

Negotiation of identities in communication entails affirming the identities we want others to recognize in us and ascription of identities we mutually assign to each other in communication. The study of intercultural communication focuses on cultural identity as the principal identity component that defines intercultural communication. In this article, the assumption that cultural group membership factors determine the context of intercultural communication is questioned. The article examines how intercultural interlocutors negotiate their identities in various intercultural interactions. The aims of the research presented in this paper are: 1) to examine which identities - cultural, personal, or social - intercultural interlocutors activate in intercultural communication; 2) to determine whether interlocutors’ intercultural communication is largely influenced by their cultural identities; 3) and to identify situations in which they activate their cultural identities (3). The research data were collected from 263 international students studying at Masaryk University in Brno in the years 2010 - 2016. Although the research results are not conclusive, they indicate that cultural identities predominate in the students’ ethnocentric views and that stereotypes constrain the students’ cultural identities and affect the negotiation of identities in intercultural communication.
Speech presentation: A preliminary review from multiple perspectives
Authors: Guo Hua
Published: March 2017

Speech presentation, largely a stylistic notion, attracts scholars’ attention from various fields. While narrative theory is devoted to studies on language in fiction and treats speech presentation in close relation with narrator’s distance from the narrative and intervention in the character’s utterance, linguistic perspectives range from categorical classification of speech presentation structures to theoretical exploration into its nature and function. In the meantime stylistics recognizes the compositional and communicative process of speech presentation in narrative and examines linguistic devices by which the narrator orients the reader and creates a text’s style. This paper reviews a number of approaches to speech presentation and the distinctive features of each approach shed light on further stylistic studies on this important discursive phenomenon.