bluuebunny/crossref_metadata_2025 huggingface dataset:
Have the Manicheans Returned? An Augustinian Alternative to Situationist Psychology
Authors: Kim Andrew
Published: October 2013

Are human beings ever blameworthy for the choices they make? This essay offers a comparative analysis of two systems of thought that argue they are not. The first is Manicheanism, which places blame on a depraved nature within the individual and in competition with a good nature residing within the same person. The good nature is not accountable for the actions of the bad one. The second is situationist psychology, which posits that situations influence behavior more than any alleged robust traits inhering within the personality of the individual. We are thus not to blame for our bad actions which are produced not by our own volition, but by situational stimuli that are beyond our control. This essay critiques both of these systems of thought from an Augustinian perspective. I argue that while situationism does have something to commend, Augustine’s views on the constraining force of a sinful secunda natura, which influences but does not determine behavior, is a preferable alternative to both Manicheanism and situationism.
Homes for Games: A filmic interpretation of Sochi 2014 and resettlement in Imeretinskaya Bay
Authors: Wurster Steffi
Published: October 2013

The film “Homes for Games” consists of documentary footage showing the profound transformation of Imeretinskaya Bay, the location of the Olympic Coastal Cluster in Sochi, situated on the Black Sea coast near the border between Georgia/Abkhazia and Russia. In the tradition of local history, the documentary footage collects the local residents’ stories about their experiences with the Olympic relocation. Through the people’s narrations that come from periodic interviews, the film explores the links between space, place and the creation of individual and collective identity. By commenting on video stills and specific film sequences, this article reflects the gradual replacement of fields and settlements as the master plan of the Games is being implemented. By giving voice to the residents, whose views go unnoticed in the official media, the film shows to what extent the Olympic Winter Games change the residents’ living and working situation.
Should pay-for-performance schemes be locally designed? evidence from the commissioning for quality and innovation (CQUIN) framework
Authors: Kristensen Søren Rud , McDonald Ruth , Sutton Matt
Published: October 2013

Objectives

It is increasingly recognized that the design characteristics of pay-for-performance schemes are important in determining their impact. One important but under-studied design aspect is the extent to which pay-for-performance schemes reflect local priorities. The English Department of Health White Paper High Quality Care for All introduced a Commissioning for Quality and Innovation (CQUIN) Framework from April 2009, under which local commissioners and providers were required to negotiate and implement an annual pay-for-performance scheme. In 2010/2011, these schemes covered 1.5% (£1.0bn) of NHS expenditure. Local design was intended to offer flexibility to local priorities and generate local enthusiasm, while retaining good design properties of focusing on outcomes and processes with a clear link to quality, using established indicators where possible, and covering three key domains of quality (safety; effectiveness; patient experience) and innovation. We assess the extent to which local design achieved these objectives.

Methods

Quantitative analysis of 337 locally negotiated CQUIN schemes in 2010/2011, along with qualitative analysis of 373 meetings (comprising 800 hours of observation) and 230 formal interviews (audio-recorded and transcribed verbatim) with NHS staff in 12 case study sites.

Results

The local development process was successful in identifying variation in local needs and priorities for quality improvement but the involvement of frontline clinical staff was insufficient to generate local enthusiasm around the schemes. The schemes did not in general live up to the requirements set by the Department of Health to ensure that local schemes addressed the original objectives for the CQUIN framework.

Conclusions

While there is clearly an important case for local strategic and clinical input into the design of pay-for-performance schemes, this should be kept separate from the technical design process, which involves defining indicators, agreeing thresholds, and setting prices. These tasks require expertise that is unlikely to exist in each locality. The CQUIN framework potentially offered an opportunity to learn how technical design influenced outcome but due to the high degree of local experimentation and little systematic collection of key variables, it is difficult to derive lessons from this unstructured experiment about the impact and importance of different technical design factors on the effectiveness of pay-for-performance. Balancing the policy goal of localism with the objective of improving patient outcomes leads us to conclude that a somewhat firmer national framework would be preferable to a fully locally designed framework.
Choosing health: qualitative evidence from the experiences of personal health budget holders
Authors: Davidson Jacqueline , Baxter Kate , Glendinning Caroline , Irvine Annie
Published: October 2013

Objectives

Personal health budgets were piloted in the English National Health Service between 2009 and 2012. Semi-structured interviews with a sub-sample of early budget holders aimed to explore their experiences of receiving and using a budget.

Method

Over 2000 people from 20 pilot sites were recruited to a multi-method evaluation of the personal health budget pilots. A sub-sample of 58 people was selected for qualitative interviews three months after the offer of a budget; 52 were re-interviewed six months later. The purposively selected sample reflected a range of health conditions, locality, age and gender.

Results

Personal health budgets were reported to have positive impacts on health, health care and relatives/family. Benefits often extended beyond the condition for which the budget had been awarded. However, interviewees rarely knew the level of their budget; some reported difficulty in agreeing acceptable uses for their budget; and delays could occur in procuring chosen services or equipment.

Conclusion

Patients’ experiences offer valuable insights for the roll-out of personal health budgets beyond the pilot phase. Flexibility in how budgets are used may allow maximum benefits to be derived. Clear information about what budgets can and cannot be used for, with suggestions offered, will be useful. People with newly diagnosed or recent sudden onset conditions may need more help to plan their support, but all budget holders are likely to benefit from regular contact with staff for reassurance and continued motivation.
At the crossroads of anthropology and epidemiology: Current research in cultural psychiatry in the UK
Authors: Dein Simon , Bhui Kamaldeep Singh
Published: October 2013

Cultural psychiatry research in the UK comprises a broad range of diverse methodologies, academic disciplines, and subject areas. Methodologies range from epidemiological to anthropological/ethnographic to health services research; mixed methods research is becoming increasingly popular, as are public health and health promotional topics. After briefly outlining the history of cultural psychiatry in the UK we will discuss contemporary research. Prominent themes include: the epidemiology of schizophrenia among Africans/Afro-Caribbeans, migration and mental health, racism and mental health, cultural identity, pathways to care, explanatory models of mental illness, cultural competence, and the subjective experiences of healthcare provision among specific ethnic groups such as Bangladeshis and Pakistanis. Another strand of research that is attracting increasing academic attention focuses upon the relationship between religion, spirituality, and mental health, in particular, the phenomenology of religious experience and its mental health ramifications, as well as recent work examining the complex links between theology and psychiatry. The paper ends by appraising the contributions of British cultural psychiatrists to the discipline of cultural psychiatry and suggesting promising areas for future research.
An experimental investigation into the effect of hydrodynamic cavitation on diesel
Authors: Lockett Russel D , Jeshani Mahesh
Published: October 2013

Samples of commercial diesel were subjected to 40 h of intense cavitation flow across a diesel injector in a specially designed high-pressure recirculation flow rig. Changes to the optical absorption and scattering properties of the diesel over time were identified by the continuous measurement of spectral extinction coefficients at 405 nm by means of a simple optical arrangement. Identical diesel samples were maintained at 70 °C for 40 h in a heated water bath, in order to distinguish the effects of hydrodynamic cavitation and temperature on the cavitated diesel samples. The commercial diesel samples subjected to high-pressure cavitation flow and water bath heating revealed a response to the flow and temperature history that was identified by an increase in the optical extinction coefficients of the cavitated and heated samples. The contribution of cavitation flow and temperature to the variation in spectral extinction coefficient was identified. It was concluded that the increases observed in the spectral extinction coefficients of the cavitated commercial diesels were caused by the cavitation affecting the aromatics in the commercial diesel samples.
Understanding and managing syphilis
Authors: Gray Thomas G , Powles Elizabeth
Published: October 2013

It was once thought that improvements in sexual health care had nearly eradicated syphilis in developed countries. However, it remained a worldwide problem, and in recent years has begun to resurge in Western Europe, China and the USA. There are an estimated 12 000 000 individuals infected globally each year. Syphilis has many clinical manifestations and is known for imitating other conditions; Sir William Osler famously said: ‘he who knows syphilis knows medicine’. It is highly probable that most GPs will come across syphilis in their working lives and understanding its clinical features, investigation, diagnosis and management is essential.
Evaluation of Parent-Child Pairs on Antiretroviral Therapy in Separate Adult and Pediatric Clinics
Authors: Bost Brian P. , Fairlie Lee , Karstaedt Alan S.
Published: October 2013

In Africa, HIV infection is considered a family disease. A retrospective cohort analysis was performed to describe the characteristics and outcome in 35 parent–child pairs taking antiretroviral therapy (ART) in separate adult and pediatric HIV clinics. In 26 pairs, ART was first initiated in children. Baseline median CD4 count was 122/mm3 in adults and 376/mm3 in children. World Health Organization stage 3 or 4 disease affected 49% of adults and 83% of children. In all, 3 parents and 1 child died. Hospitalization, poor adherence, missed appointments, or regimen change affected >50% of pairs on ART. Following tuberculosis diagnosis in their parents, 2 of the 5 children were not investigated. By week 104, 29 (83%) pairs remained on ART, and 69% of patients on ART were virologically suppressed. Parent–child pairs with advanced HIV infection had good outcomes when cared for in separate clinics. Establishing lines of communication between clinics is important. Family-centered services may provide more integrated care.
Characterization of the heart transcriptome of the white shark (Carcharodon carcharias)
Authors: Richards Vincent P , Suzuki Haruo , Stanhope Michael J , Shivji Mahmood S
Published: October 2013

Background

The white shark (Carcharodon carcharias) is a globally distributed, apex predator possessing physical, physiological, and behavioral traits that have garnered it significant public attention. In addition to interest in the genetic basis of its form and function, as a representative of the oldest extant jawed vertebrate lineage, white sharks are also of conservation concern due to their small population size and threat from overfishing. Despite this, surprisingly little is known about the biology of white sharks, and genomic resources are unavailable. To address this deficit, we combined Roche-454 and Illumina sequencing technologies to characterize the first transciptome of any tissue for this species.

Results

From white shark heart cDNA we generated 665,399 Roche 454 reads (median length 387-bp) that were assembled into 141,626 contigs (mean length 503-bp). We also generated 78,566,588 Illumina reads, which we aligned to the 454 contigs producing 105,014 454/Illumina consensus sequences. To these, we added 3,432 non-singleton 454 contigs. By comparing these sequences to the UniProtKB/Swiss-Prot database we were able to annotate 21,019 translated open reading frames (ORFs) of ≥ 20 amino acids. Of these, 19,277 were additionally assigned Gene Ontology (GO) functional annotations. While acknowledging the limitations of our single tissue transcriptome, Fisher tests showed the white shark transcriptome to be significantly enriched for numerous metabolic GO terms compared to the zebra fish and human transcriptomes, with white shark showing more similarity to human than to zebra fish (i.e. fewer terms were significantly different). We also compared the transcriptome to other available elasmobranch sequences, for signatures of positive selection and identified several genes of putative adaptive significance on the white shark lineage. The white shark transcriptome also contained 8,404 microsatellites (dinucleotide, trinucleotide, or tetranucleotide motifs ≥ five perfect repeats). Detailed characterization of these microsatellites showed that ORFs with trinucleotide repeats, were significantly enriched for transcription regulatory roles and that trinucleotide frequency within ORFs was lower than for a wide range of taxonomic groups including other vertebrates.

Conclusion

The white shark heart transcriptome represents a valuable resource for future elasmobranch functional and comparative genomic studies, as well as for population and other biological studies vital for effective conservation of this globally vulnerable species.
Poly-L-glutamate/glutamine synthesis in the cell wall of Mycobacterium bovisis regulated in response to nitrogen availability
Authors: Tripathi Deeksha , Chandra Harish , Bhatnagar Rakesh
Published: October 2013

Background

The cell wall of pathogenic mycobacteria is known to possess poly-L-glutamine (PLG) layer. PLG synthesis has been directly linked to glutamine synthetase (GS) enzyme. glnA1 gene encodes for GS enzyme in mycobacteria. PLG layer is absent in cell wall of avirulent Mycobacterium smegmatis, although M. smegmatis strain expressing GS enzyme of pathogenic mycobacteria can synthesize PLG layer in the cell wall. The role of GS enzyme has been extensively studied in Mycobacterium tuberculosis, however, little is known about GS enzyme in other mycobacterial species. Mycobacterium bovis, as an intracellular pathogen encounters nitrogen stress inside macrophages, thus it has developed nitrogen assimilatory pathways to survive in adverse conditions. We have investigated the expression and activity of M. bovis GS in response to nitrogen availability and effect on synthesis of PLG layer in the cell wall. M. smegmatis was used as a model to study the behaviour of glnA1 locus of M. bovis.

Results

We observed that GS expression and activity decreased significantly in high nitrogen grown conditions. In high nitrogen conditions, the amount of PLG in cell wall was drastically reduced (below detectable limits) as compared to low nitrogen condition in M. bovis and in M. smegmatis strain complemented with M. bovis glnA1. Additionally, biofilm formation by M. smegmatis strain complemented with M. bovis glnA1 was increased than the wild type M. smegmatis strain.

Conclusions

The physiological regulation of GS in M. bovis was found to be similar to that reported in other mycobacteria but this data revealed that PLG synthesis in the cell wall of pathogenic mycobacteria occurs only in nitrogen limiting conditions and on the contrary high nitrogen conditions inhibit PLG synthesis. This indicates that PLG synthesis may be a form of nitrogen assimilatory pathway during ammonium starvation in virulent mycobacteria. Also, we have found that M. smegmatis complemented with M. bovis glnA1 was more efficient in biofilm formation than the wild type strain. This indicates that PLG layer favors biofilm formation. This study demonstrate that the nitrogen availability not only regulates GS expression and activity in M. bovis but also affects cell surface properties by modulating synthesis of PLG.
Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice
Authors: Ma Xiaoxing , Turnbull Patrick , Peterson Randy , Turnbull John
Published: October 2013

Background

The developmental morphogen sonic hedgehog (Shh) may continue to play a trophic role in the support of terminally-differentiated motor neurons, of potential relevance to motor neuron disease. In addition, it may support the proliferation and differentiation of endogenous stem cells along motor neuronal lineages. As such, we have examined the trophic and proliferative effects of Shh supplementation or Shh antagonism in embryonic spinal cord cell cultures derived from wildtype or G93A SOD1 mice, a mouse model of amyotrophic lateral sclerosis.

Results

Shh supported survival, and stimulated growth of motor neurons, neurite outgrowth, and neurosphere formation in primary culture derived from both G93A SOD1 and WT mice. Shh increased the percentage of ciliated motor neurons, especially in G93A SOD1 culture. Shh-treated cultures showed increased neuronal proliferation compared to controls and especially cyclopamine treated cultures, from G93A SOD1 and WT mice. Moreover, Shh enhanced cell survival and differentiation of motor neuron precursors in WT culture.

Conclusions

Shh is neurotrophic to motor neurons and has mitogenic effects in WT and mSOD1 G93A culture in vitro.
Cardiovascular screening in rheumatoid arthritis: a cross-sectional primary care database study
Authors: Monk Helen L , Muller Sara , Mallen Christian D , Hider Samantha L
Published: October 2013

Background

Patients with rheumatoid arthritis (RA) are known to be at increased risk of vascular disease. It is not known whether screening for vascular risk factors occurs in primary care. The aim of this study was to determine whether guidance advocating cardiovascular screening in RA patients is being implemented in primary care.

Methods

This study was undertaken in a UK primary care consultation database. All patients with a diagnosis of RA between 2000 and 2008, and still registered with the GP practice in 2009 were matched by age, gender and GP practice to three non-RA patients. Evidence of screening for five traditional vascular risk factors (blood pressure, lipids, glucose, weight, smoking) was compared in those with and without RA using logistic regression models. A comparison was also made with diabetes.

Results

401 RA patients were identified and matched to 1198 non-RA patients. No differences in the overall rates of screening were found (all five risk factors: RA 24.9% vs no RA 25.6%), but RA patients were more likely to have a smoking status recorded (67% versus 62%). In contrast, those with diabetes were up to 12 times as likely to receive vascular screening.

Conclusions

Despite the excess risk of vascular disease in patients with RA being of a similar magnitude to that seen in diabetes, patients with RA did not receive additional CVD screening in primary care, although this was achieved in patients with diabetes. More emphasis needs to be placed on ensuring those with RA are actively screened for cardiovascular disease in primary care.
Association of interleukin-33 gene single nucleotide polymorphisms with ischemic stroke in north Chinese population
Authors: Guo Liang , Zhou Xinghu , Guo Xiaofan , Zhang Xingang , Sun Yingxian
Published: October 2013

Background

IL-33, an IL-1-like cytokine, is a ligand for IL1RL1, which is an important effector molecule of type 2 T helper responses. Although IL-33/IL1RL1 interaction has been suggested to be important in the development of atherosclerosis, genetic influences of the polymorphisms of IL33 in human ischemic stroke are unclear. The aim of this study was to examine whether the single nucleotide polymorphisms in IL33 are associated with ischemic stroke in Northern Chinese population.

Methods

We used a nested case–control study involving 90 ischemic stroke patients and 270 age-matched, sex-matched and blood pressure-matched non-ischemic stroke controls from a rural population and determined the genotypes of four polymorphisms (rs1929992, rs10975519, rs4742170, rs16924159) in IL33 by Snapshot SNP genotyping assays to assess any links with ischemic stroke.

Results

Univariate analysis showed two single nucleotide polymorphisms (rs1929992, rs4742170) in IL33 were associated with ischemic stroke in additive, dominant, and recessive model. Binary Logistic Regression shows that rs4742170 variation is the most important factor associated with ischemic stroke (adjusted odds ratio (OR) = 1.880, 95% confidence interval (CI) = 1.316-2.686 in an additive model; OR = 2.091, CI = 1.249-3.498 in a dominant model; OR = 2.623, CI = 1.366-5.036 in a recessive model).

Conclusion

In this sample of patients, genetic variation of rs4742170 in IL33 is significantly associated with the developing of ischemic stroke.
Optimising the accuracy of blood pressure monitoring in chronic kidney disease: the utility of BpTRU
Authors: Brothwell Shona , Dutton Mary , Ferro Charles , Stringer Stephanie , Cockwell Paul
Published: October 2013

Background

Accurate blood pressure monitoring is critical for the management of chronic kidney disease, but changes in management in secondary care clinics may be based on a single blood pressure reading, with a subsequent lack of accuracy. The aim of this study was to evaluate a fully automated sphygmomanometer for optimising the accuracy of blood pressure measurements in the setting of secondary care renal clinics.

Methods

Patients had routine blood pressure measurements with a calibrated DINAMAP PRO400 monitor in a clinical assessment room. Patients then underwent repeat assessment with a DINAMAP PRO400 monitor and BpTRU device and subsequent 24 hour ambulatory blood pressure monitoring (ABPM).

Results

The BpTRU systolic (± SD) reading (117.3 ± 14.1 mmHg) was significantly lower than the routine clinic mean systolic blood pressure (143.8 ± 15.5 mmHg; P < 0.001) and the repeat blood pressure taken with a DINAMAP PRO400 monitor in a quiet room (129.9 ± 19.9 mmHg; P < 0.001). The routine clinic mean diastolic (82.4 ± 11.2 mmHg) was significantly higher than the BpTRU reading (78.4 ± 10.0 mmHg; P < 0.001). Clinic BpTRU measurements were not significantly different to the daytime mean or overall mean of 24 hour ABPM.

Conclusions

In patients with CKD, routine clinic blood pressure measurements were significantly higher than measurements using a BpTRU machine in a quiet room, but there was no significant difference in this setting between BpTRU readings and 24 hour ABPM. Adjusting clinic protocols to utilise the most accurate blood pressure technique available is a simple manoeuvre that could deliver major improvements in clinical practice.
Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
Authors: Milosevic Jelena , Klinge Johanna , Borg Anna-Lena , Foukakis Theodoros , Bergh Jonas , Tobin Nicholas P
Published: October 2013

Background

Long-term estrogen deprivation models are widely employed in an in vitro setting to recapitulate the hormonal milieu of breast cancer patients treated with endocrine therapy. Despite the wealth information we have garnered from these models thus far, a comprehensive time-course analysis of the estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER-2/neu) receptors on the gene and protein level, coupled with expression array data is currently lacking. We aimed to address this knowledge gap in order to enhance our understanding of endocrine therapy resistance in breast cancer patients.

Methods

ER positive MCF7 and BT474 breast cancer cells were grown in estrogen depleted medium for 10 months with the ER negative MDA-MB-231 cell line employed as control. ER, PR and HER-2/neu expression were analysed at defined short and long-term time points by immunocytochemistry (ICC), and quantitative real-time RT-PCR (qRT-PCR). Microarray analysis was performed on representative samples.

Results

MCF7 cells cultured in estrogen depleted medium displayed decreasing expression of ER up to 8 weeks, which was then re-expressed at 10 months. PR was also down-regulated at early time points and remained so for the duration of the study. BT474 cells generally displayed no changes in ER during the first 8 weeks of deprivation, however its expression was significantly decreased at 10 months. PR expression was also down-regulated early in BT474 samples and was absent at later time points. Finally, microarray data revealed that genes and cell processes down-regulated in both cell lines at 6 weeks overlapped with those down-regulated in aromatase inhibitor treated breast cancer patients.

Conclusions

Our data demonstrate that expression of ER, PR, and cell metabolic/proliferative processes are unstable in response to long-term estrogen deprivation in breast cancer cell lines. These results mirror recent clinical findings and again emphasize the utility of LTED models in translational research.
Detection of serological biomarkers by proximity extension assay for detection of colorectal neoplasias in symptomatic individuals
Authors: Thorsen Stine Buch , Lundberg Martin , Villablanca Andrea , Christensen Sarah Louise T , Belling Kirstine Christensen , Nielsen Birgitte Sander , Knowles Mick , Gee Nick , Nielsen Hans Jørgen , Brünner Nils , Christensen Ib Jarle , Fredriksson Simon , Stenvang Jan , Assarsson Erika
Published: October 2013

Background

Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular markers have been approved for daily clinical use.

Methods

In order to improve the translation of biomarkers from the bench to clinical practice we initiated a biomarker study focusing on a novel technique, the proximity extension assay, with multiplexing capability and the possible additive effect obtained from biomarker panels. We performed a screening of 74 different biomarkers in plasma derived from a case–control sample set consisting of symptomatic individuals representing CRC patients, patients with adenoma, patients with non-neoplastic large bowel diseases and healthy individuals.

Results

After statistical evaluation we found 12 significant indicators of CRC and the receiver operating characteristic (ROC) curve of Carcinoembryonic antigen (CEA), Transferrin Receptor-1 (TFRC), Macrophage migration inhibitory factor (MIF), Osteopontin (OPN/SPP1) and cancer antigen 242 (CA242) showed additive effect. This biomarker panel identified CRC patients with a sensitivity of 56% at 90% specificity and thus the performance is sufficiently high to further investigate this combination of five proteins as serological biomarkers for detection of CRC. Furthermore, when applying the indicators to identify early-stage CRC a combination of CEA, TFRC and CA242 resulted in a ROC curve with an area under the curve of 0.861.

Conclusions

Five plasma protein biomarkers were found to be potential CRC discriminators and three of these were additionally found to be discriminators of early-stage CRC. These explorative data in symptomatic individuals demonstrates the feasibility of the multiplex proximity extension assay for screening of potential serological protein biomarkers and warrants independent analyses in a larger sample cohort, including asymptomatic individuals, to further validate the performances of our CRC biomarker panel.
Radiation testing of the AeroForm co2-based breast tissue expander implant
Authors: Rembert James L , Heitz Roxana , Hoffman Adam
Published: October 2013

Background

Tissue expanders are used in breast reconstruction after mastectomy to stretch the remaining tissue to create space for placement of permanent breast implants. The AeroForm™ Tissue Expander, developed by AirXpanders™ Inc., contains electronic components designed to activate the release of carbon dioxide from an internal reservoir to inflate the expander. Breast cancer patients who undergo mastectomy and tissue expander/implant-based breast reconstruction may require radiation therapy at doses up to 50–60 Gy while the expander is in place. The ionizing radiation used in postmastectomy radiation therapy interacts with electronic components in medical implants, which may cause degradation in performance above certain levels. Most commercial electronic components used in medical devices, such as complementary metal-oxide semiconductor or bipolar integrated circuits can withstand radiation levels in the 50 Gy range without any performance degradation. Beyond this level, the performance may still be sufficient to guarantee functionality, but this needs to be confirmed at the system and electronic circuit level. We assessed the impact of radiation levels up to 75 Gy on 32 AeroForm™ Tissue Expanders (AirXpanders, Inc., Palo Alto, CA USA) and on the associated internal printed circuit assemblies.

Findings

The electronics inside the AeroForm™ Tissue Expander implant continued to function properly after exposure to radiation levels up to 75 Gy, which is well above the maximum total dose level typically used in postmastectomy radiation therapy.

Conclusions

Standard postmastectomy radiation therapy doses do not damage or affect the functionality of the AeroForm™ Tissue Expander.
The prevalence and incidence, resource use and financial costs of treating people with attention deficit/hyperactivity disorder (ADHD) in the United Kingdom (1998 to 2010)
Authors: Holden Sarah E , Jenkins-Jones Sara , Poole Chris D , Morgan Christopher Ll , Coghill David , Currie Craig J
Published: October 2013

Background

Attention deficit/hyperactivity disorder (ADHD) is a common disorder that often presents in childhood and is associated with increased healthcare resource use. The aims of this study were to characterise the epidemiology of diagnosed ADHD in the UK and determine the resource use and financial costs of care.

Methods

For this retrospective, observational cohort study, patients newly diagnosed with ADHD between 1998 and 2010 were identified from the UK Clinical Practice Research Datalink (CPRD) and matched to a randomly drawn control group without a diagnosis of ADHD. The prevalence and incidence of diagnosed ADHD were calculated. Resource utilisation and corresponding financial costs post-diagnosis were estimated for general practice contacts, investigations, prescriptions, outpatient appointments, and inpatient admissions.

Results

Incidence of diagnosed ADHD (and percentage change using 1998 as a reference) increased from 6.9 per 100,000 population in 1998 to 12.2 per 100,000 (78%) in 2007 and then fell to 9.9 per 100,000 (44%) by 2009. The corresponding prevalence figures were 30.5, 88.9 (192%) and 81.5 (167%) per 100,000. Incidence and prevalence were higher in males than females. Mean annual total healthcare costs were higher for ADHD cases than controls (£1,327 versus £328 for year 1, £1,196 vs. £337 for year 2, £1,148 vs. £316 for year 3, £1,126 vs. £325 for year 4, and £1,112 vs. £361 for year 5).

Conclusions

The prevalence of diagnosed ADHD in routine practice in the UK was notably lower than in previous reports, and both prevalence and incidence of diagnosed ADHD in primary care have fallen since 2007. Financial costs were more than four times higher in those with ADHD than in those without ADHD.
MicroRNA-20b and ERK1/2 pathway independently regulate the expression of tissue factor in hematopoietic and trophoblastic differentiation of human embryonic stem cells
Authors: Yu Yan-Hui , Wu Deng-Shu , Huang Fang-Fang , Zhang Zheng , Liu Lin-Xin , Zhang Jian , Zhan Hui-En , Peng Min-Yuan , Zeng Hui , Chen Fang-Ping
Published: October 2013

Introduction

Tissue factor (TF) is expressed in various types of cells. TF expression is essential for many biological processes, such as blood coagulation and embryonic development, while its high expression in stem cells often leads to failure of transplantation. In this study, we used the human embryonic stem cell (hESC) culture system to understand the molecular mechanisms by which TF expression is regulated in hESC-derived hematopoietic and trophoblastic cells.

Methods

hESCs were induced in vitro to differentiate into hematopoietic and trophoblastic cells. TF expression in various types of cells during these differentiation processes was examined by quantitative real-time polymerase chain reaction analysis and western blot analysis. The regulatory mechanisms of TF expression were investigated by miRNA expression analysis, luciferase report assay, TF mRNA and protein analysis, and pathway phosphorylation analysis.

Results

We first found that TF was expressed only in trophoblasts and granulocyte–monocyte (G-M) cells differentiated from hESCs; and then demonstrated that miR-20b downregulated and Erk1/2 signaling pathway upregulated the TF expression in trophoblasts and G-M cells. Finally, we found that miR-20b downregulated the TF expression independently of the Erk1/2 signaling pathway.

Conclusions

The miR-20b and Erk1/2 pathway independently regulate expression of TF in trophoblasts and G-M cells differentiated from hESCs. These findings will open an avenue to further illustrate the functions of TF in various biological processes.
Self-supplementation and effects of dietary antioxidants during acute thermal stress
Authors: Beaulieu Michaël , Haas Anabel , Schaefer H. Martin
Published: October 2013

Thermal stress leads to increased production of Reactive Oxygen Species (ROS). If the organism is not able to simultaneously mount an efficient antioxidant defense system, this may lead to increased oxidative damage, potentially deleterious in terms of health and fitness. Exposure to cold or heat is therefore expected to be associated with a high demand for antioxidants. In agreement, several studies have shown that supplementing the diet of thermally-stressed organisms with antioxidants leads to a reduction of oxidative damage. However, whether organisms can actively supplement their diet with antioxidants to alleviate temperature-induced oxidative damage is unknown. Here, we show that captive Gouldian finches (Erythrura gouldiae) supplement their diet more with seeds rich in antioxidants below than within their thermoneutral zone. Moreover, having access to seeds rich in antioxidants at temperature below thermoneutrality decreases their oxidative damage. These results indicate that, when facing a thermal challenge, animals are able to take advantage of the antioxidant properties of their food to improve their oxidative balance. Having access to food resources rich in antioxidants may therefore be of primary importance for organisms in their natural habitat, as it may help them to cope with oxidative constraints due to challenging temperature regimes.
Understanding the Mechanisms Through Which an Influential Early Childhood Program Boosted Adult Outcomes
Authors: Heckman James , Pinto Rodrigo , Savelyev Peter
Published: October 2013

A growing literature establishes that high quality early childhood interventions targeted toward disadvantaged children have substantial impacts on later life outcomes. Little is known about the mechanisms producing these impacts. This paper uses longitudinal data on cognitive and personality skills from an experimental evaluation of the influential Perry Preschool program to analyze the channels through which the program boosted both male and female participant outcomes. Experimentally induced changes in personality skills explain a sizable portion of adult treatment effects. (JEL I21, I24, I28, J13, J24)
Trade Liberalization and Embedded Institutional Reform: Evidence from Chinese Exporters
Authors: Khandelwal Amit K , Schott Peter K , Wei Shang-Jin
Published: October 2013

If trade barriers are managed by inefficient institutions, trade liberalization can lead to greater-than-expected gains. We examine Chinese textile and clothing exports before and after the elimination of externally imposed export quotas. Both the surge in export volume and the decline in export prices following quota removal are driven by net entry. This outcome is inconsistent with a model in which quotas are allocated based on firm productivity, implying misallocation of resources. Removing this misallocation accounts for a substantial share of the overall gain in productivity associated with quota removal. (JEL F13, F14, L67, O14, O19, P23, P33)
Does the Classic Microfinance Model Discourage Entrepreneurship Among the Poor? Experimental Evidence from India
Authors: Field Erica , Pande Rohini , Papp John , Rigol Natalia
Published: October 2013

Do the repayment requirements of the classic microfinance contract inhibit investment in high-return but illiquid business opportunities among the poor? Using a field experiment, we compare the classic contract which requires that repayment begin immediately after loan disbursement to a contract that includes a two-month grace period. The provision of a grace period increased short-run business investment and long-run profits but also default rates. The results, thus, indicate that debt contracts that require early repayment discourage illiquid risky investment and thereby limit the potential impact of microfinance on microenterprise growth and household poverty. (JEL A21, G32, I32, L25, L26, O15, O16)
How the West “Invented” Fertility Restriction
Authors: Voigtländer Nico , Voth Hans-Joachim
Published: October 2013

We analyze the emergence of the first socioeconomic institution in history limiting fertility: west of a line from St. Petersburg to Trieste, the European Marriage Pattern (EMP) reduced childbirths by approximately one-third between the fourteenth and eighteenth century. To explain the rise of EMP we build a two-sector model of agricultural production—grain and livestock. Women have a comparative advantage in animal husbandry. After the Black Death in 1348–1350, land abundance triggered a shift toward the pastoral sector. This improved female employment prospects, leading to later marriages. Using detailed data from England, we provide strong evidence for our mechanism. (JEL J12, J13, J16, N33, N53, Q11)
Incarceration and Incapacitation: Evidence from the 2006 Italian Collective Pardon
Authors: Buonanno Paolo , Raphael Steven
Published: October 2013

In August 2006, the Italian government released one-third of the nation's prison inmates via a national collective pardon. We test for a discontinuous break in national crime rates corresponding to the mass release. We also test for the effect of the return of the incarceration rate to its predicted steady state level on national crime rates. Finally, we exploit regional variation in prison releases based on the province of residence of pardoned inmates. All three sources of variation yield substantial incapacitation effect estimates and suggest that the crime-preventing effects of incarceration diminish with increases in the incarceration rate. (JEL K42)
Consumer Spending and the Economic Stimulus Payments of 2008
Authors: Parker Jonathan A , Souleles Nicholas S , Johnson David S , McClelland Robert
Published: October 2013

We measure the change in household spending caused by receipt of the economic stimulus payments of 2008, using questions added to the Consumer Expenditure Survey and variation from the randomized timing of disbursement. Households spent 12–30 percent (depending on specification) of their payments on nondurable goods during the three-month period of payment receipt, and a significant amount more on durable goods, primarily vehicles, bringing the total response to 50–90 percent of the payments. The responses are substantial and significant for older, lower-income, and home-owning households. Spending does not vary significantly with the method of disbursement (check versus electronic transfer). (JEL D12, D14, E21, E62)
News Shocks and the Slope of the Term Structure of Interest Rates
Authors: Kurmann André , Otrok Christopher
Published: October 2013

We adopt a statistical approach to identify the shocks that explain most of the fluctuations of the slope of the term structure of interest rates. We find that one shock can explain the majority of unpredictable movements in the slope. Impulse response functions lead us to interpret this shock as news about future total factor productivity (TFP). By showing that “slope shocks” are essentially “TFP news shocks” we provide a new explanation for the relationship between the slope and macroeconomic fundamentals. Our results also provide a new empirical benchmark for structural models at the intersection of macroeconomics and finance. (JEL E23, E43, E52, G12, G14)
Clinicolaboratory Study of Mother-to-Neonate Transmission of Hepatitis E Virus in Egypt
Authors: Zaki Maysaa El Sayed , Aal Amena Abd El , Badawy Ahmed , El- Deeb Douaa Raafat , El-Kheir Nermin Youssef Abo
Published: October 2013

Objectives:

To study the presence of hepatitis E viremia in neonates with congenital infections.

Methods:

We included 29 neonates with clinical signs and symptoms suggesting congenital infections, along with their mothers. The control group comprised 29 healthy neonates and their mothers. Laboratory evaluations were performed for each sample for liver function profiles and virological studies for hepatitis viruses B, C, and E.

Results:

The most common viral markers in mothers were for hepatitis C immunoglobulin G (IgG) (41%), followed by hepatitis B surface antigen (34%) and hepatitis E virus (HEV) IgG (31%). The most common presentations in neonates were respiratory distress syndrome, followed by preterm birth and signs of sepsis (both 41%) and hepatosplenomegaly (13%).

Conclusions:

This study highlights the occurrence of HEV infection among other etiological conditions causing congenital infections. Vertical transmission from mothers was common in our patients. Although HEV ran a milder course, more studies are needed.
The Truth about Crime Statistics
Authors: Lewis Chris
Published: October 2013

This paper aims to improve public understanding of crime statistics. It is based on the experience of the author as Chief Statistician at the Home Office. It takes a historical perspective, looking back over the last 60 years and forward for a further generation. It takes a technological perspective as crime is constantly changing with the development of new technologies, goods and services. It also takes a crime prevention perspective as some recent reductions in crime have followed improvements in crime prevention.

The paper concludes that the recent published falls in crime statistics are real but that the current measures are inadequate to cope with a changing trend in criminal activity, away from ‘conventional’ crimes such as robbery, theft and burglary, towards a greater concentration on Internet crime, frauds of all kinds and the various kinds of corruption associated with the global economy and the growth in electronic commerce.
The Global Need to Define Normality: The 99th Percentile Value of Cardiac Troponin
Authors: Sandoval Yader , Apple Fred S
Published: October 2013

BACKGROUND

How to select a presumably normal population for the establishment of 99th percentile cutoffs for cardiac troponin assays has not been adequately addressed. Lack of attention to this question can result in misleading medical decision cutoffs.

CONTENT

From our review of the peer-reviewed literature, including international recommendations, no uniform procedure is followed and no uniform guideline has been published by experts or regulatory agencies to guide researchers or manufacturers of cardiac troponin assays in their quest to define the health or “normality” of a reference population that is used to establish an accurate 99th percentile value. As we progress globally into the era of high-sensitivity cardiac troponin assays, we propose several suggested approaches to define presumably normal individuals by use of clinical and biomarker surrogates.

Our uniform approach to defining who is normal and who may not be normal will help to define diagnostic and risk outcomes assessments in the management of patients with suspected myocardial injury, both for use in current clinical practice and clinical research, as well as for the potential future use of cardiac troponin in primary prevention.
Twenty-five years of idiopathic calcium nephrolithiasis: has anything changed?
Authors: Nouvenne Antonio , Ticinesi Andrea , Allegri Franca , Guerra Angela , Guida Loredana , Morelli Ilaria , Borghi Loris , Meschi Tiziana
Published: October 2013

Idiopathic calcium nephrolithiasis (ICN) is a disease whose prevalence is rising. Our aim was to assess whether lifestyle indicators and habits of calcium stone formers in Italy have changed over the last 25 years, trying to establish a connection with the diffusion of Internet access. Therefore we examined the database of the Stone Clinic of Parma University Hospital and extracted 1952 (1192 M, 760 F) patients with ICN who underwent a full clinical and laboratory evaluation from 1986 to 2010. Laboratory evaluation included data on urinary 24-h volume, pH, sodium, potassium, chloride, calcium, phosphate, uric acid, magnesium, oxalate, and citrate. Patients were split in three groups on a chronological basis, according to official EUROSTAT-ISTAT data of Internet connection among families in Italy: Group 1, pre-Internet era (1986–1998, 853 patients); Group 2, narrow-band era (1999–2004, 467 patients); Group 3, broad-band era (2005–2010, 632 patients). Over the time we found a significant increase in water intake (1.37 vs. 1.78 L in men and 1.21 vs. 1.55 L in women, Group 1 vs. Group 3, p-trend<0.001) and a decrease in urinary sodium and chloride for both genders and calcium and magnesium only for males, while females experienced a slight increase in oxalate excretion. Supersaturation indexes for calcium and uric acid stones dramatically fell for both genders. The percentage of stone formers performing physical activity significantly rise (41% Group 3 vs. 8% Group 1, p<0.001) and we also found a trend of reduction in mean blood pressure. Therefore, the lifestyle of Italian idiopathic calcium stone formers has changed over the last 25 years, and the rising Internet access may have played a great role in driving this change.
K-groups for rings of finite Cohen–Macaulay type
Authors: Holm Henrik
Published: October 2013

For a local Cohen–Macaulay ring R of finite CM-type, Yoshino has
applied methods of Auslander and Reiten to compute the
Grothendieck group K0 of the category mod R of finitely
generated R-modules. For the same type of rings, we compute in
this paper the first Quillen K-group K1(mod R). We also
describe the group homomorphism R*
→ K1(mod R)
induced by the inclusion functor proj R → mod R and
illustrate our results with concrete examples.