bluuebunny/crossref_metadata_2025 huggingface dataset:
Sleep Duration, Sleep Quality, and the Development of Nonalcoholic Fatty Liver Disease: A Cohort Study
Authors: Um Yoo Jin , Chang Yoosoo , Jung Hyun-Suk , Cho In Young , Shin Jun Ho , Shin Hocheol , Wild Sarah H. , Byrne Christopher D. , Ryu Seungho
Published: October 2021

INTRODUCTION:

The longitudinal relationship between sleep duration, sleep quality, and the risk of nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to examine the association between sleep duration, sleep quality, and NAFLD development.

METHODS:

Using the Pittsburgh Sleep Quality Index, sleep duration and quality were evaluated for 143,306 NAFLD-free Korean adults with a mean age of 36.6 years, who were followed for an average of 4.0 years. Hepatic steatosis (HS) was assessed using ultrasonography and liver fibrosis by the fibrosis-4 index (FIB-4) or the NAFLD fibrosis score. Flexible parametric proportional hazard models were used to determine the hazard ratios (HRs) and 95% confidence intervals.

RESULTS:

There were 27,817 subjects with incident HS, of whom 1,471 had incident HS plus intermediate/high FIB-4. Multivariable-adjusted HRs (95% confidence intervals) for incident HS comparing sleep durations of ≤5, 6, 8, and ≥ 9 hours with 7 hours were 1.19 (1.14–1.23), 1.07 (1.04–1.10), 0.98 (0.94–1.02), and 0.95 (0.87–1.03), respectively. The corresponding HRs for incident HS plus intermediate/high FIB-4 were 1.30 (1.11–1.54), 1.14 (1.01–1.29), 1.11 (0.93–1.33), and 1.08 (0.71–1.63). The association between sleep duration and HS plus intermediate/high FIB-4 was inverse in individuals with good sleep quality but tended to be U-shaped in those with poor sleep quality. The results were similar if FIB-4 was replaced by the NAFLD fibrosis score.

DISCUSSION:

In young adults, short sleep duration was independently associated with an increased risk of incident NAFLD with or without intermediate/high fibrosis score, suggesting a role for inadequate sleep quantity in NAFLD risk and severity.
Clinical and genetic heterogeneity of micronodular adrenal hyperplasia
Authors: Chevais A. , Beltsevich D. G. , Abrosimov A. Yu. , Derkatch D. A. , Lazareva A. A.
Published: October 2021

Micronodular adrenal hyperplasia is a rare cause of ACTH-independent Cushing syndrome. It can be divided into two entities: primary pigmented nodular adrenocortical disease (PPNAD) and non-pigmented micronodular adrenocortical disease, among which familial and sporadic forms are distinguished. The most common is the genetically determined familial form PPNAD, as one of the components of Carney complex. The vast majority of patients have identifiable pathogenic variants in the PRKAR1A gene. In addition to the PRKAR1A gene mutations, inactivating mutations in the genes encoding phosphodiesterases (PDE11A4 and PDE8B), as well as PRKACA gene amplification, have been described in individuals with isolated forms. Despite the relative antiquity of the description of micronodular adrenal hyperplasia and the Carney comlex, a detailed study of pathophysiological mechanisms, genetic and clinical aspects of this pathology, nowadays, clinicians continue to face «atypical» cases. Thus, the nature of this disease is not well understood and requires further research. This review presents the accumulated data on micronodular adrenal hyperplasia, genetics aspects, and also describes 2 unique clinical cases of isolated PPNAD with unilateral adrenalectomy results.
The role of the metabolic status of lymphocytes in the pathogenesis of rheumatoid arthritis
Authors: Skupnevsky S. V. , Pukhaeva E. G. , Badtiev A. K. , Rurua F. K. , Batagova F. E. , Farnieva Zh. G.
Published: October 2021

Objective: to study in dynamics metabolic changes in lymphocytes on the model of adjuvant-induced rheumatoid arthritis (RA) in warm-blooded animals.Material and methods. The RA model was elicited by administering Freund's complete adjuvant (AF) to male Wistar rats. Lymphocyte metabolism was corrected with a mixture of citric and succinic acids, which was injected for 4 weeks (at doses of 17 and 88 mg/kg body weight) from the first day of model formation. Animals of the control group were injected subcutaneously with isotonic sodium chloride solution. The total number of leukocytes, the size of lymphocytes and the activity of lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) in these cells were determined. Changes in the musculoskeletal system were assessed radiographically and actometrically in the «open field» model.Results and discussion. In the first 2 weeks of the experiment in the model group, an increase in the level of leukocytes by 65% compared to the control (p=0.002) was noted, an increase in the activity of lymphocytes SDH by 51% and a decrease in the total («horizontal») mobility of animals by 30% were also revealed. Subsequently, the level of leukocytes decreased by 25%, the activity of LDH and SDH – by 38%, the radius of lymphocytes – by 14% (p<0.01). The action of carboxylic acids was dose-dependent: at the maximum dose, no statistically significant differences in the total number of leukocytes, LDH and SDH activity in lymphocytes, as well as their sizes were found between the group with adjuvant- induced RA and the control group.Conclusion. In animals with adjuvant-induced RA, correction of the metabolic status of lymphocytes with a mixture of citric and succinic acids, which are key substrates of the Krebs cycle, led to a decrease in structural damage of musculoskeletal system and, as a consequence, to the maintenance of normal range of motion.
Evaluation of the effectiveness of intra-articular administration of highly purified hyaluronic acid in knee osteoarthritis in real clinical practice
Authors: Nesterenko V. A. , Byalik E. I. , Makarov M. A. , Makarov S. A. , Byalik V. E. , Roskidailo A. A. , Amirdzhanova V. N. , Nurmukhametov M. R. , Lila A. M.
Published: October 2021

Knee osteoarthritis (kOA) is a common cause of turning for medical advice, associated with chronic pain and disability. One of the methods of OA treatment is the local administration of hyaluronic acid (HA) drugs.Objective: to evaluate the effectiveness of intra-articular (IA) administration of highly purified HA (Armaviskon Plus) in kOA.Patients and methods. The study group consisted of 58 patients (74.1% women and 25.9% men, aged 59.5±11.8 years) with kOA, experiencing moderate/severe pain (≥40 mm on a visual analogue scale, VAS). All patients received IA injection of HA Armaviskon Plus (2 ml of a 1.5% solution), 2 injections with an interval of 7 days. The effectiveness criterion was the dynamics of pain at rest and during movement (VAS 0-100 mm) and the function of the knee joint according to a numerical rating scale (NRS 0-100 points) 2 weeks, 1 and 3 months after administration of therapy.Results and discussion. During the treatment, there was a significant improvement in all indicators. The average severity of pain during movement at baseline, after 2 weeks, 1 and 3 months was 50 [40; 60], 30 [20; 40], 15 [0; 30], 20 [0; 30] mm (p<0.001), at rest 20 [10; 40], 5 [0; 20], 0 [0; 20], 10 [0; 20] mm (p<0.05) by VAS. The average values of functional indicators were 40 [10; 60], 10 [0; 40], 20 [0; 40], 10 [10; 30] scores according to the NRS. A decrease in non-steroidal anti-inflammatory drugs demand was recorded: 67.1% of patients were initially taking them, after 3 months – 36.1% (p<0.001). No serious adverse reactions were noted.Conclusion. IA administration of HA is an effective and safe method for the treatment of kOA. Armaviskon Plus, a highly purified high-molecular- weight HA drug, has shown good results in pain reduction and improvement of function in knee OA as well as a favorable safety profile, which makes it possible to recommend its use in real clinical practice.
Difficult-to-treat rheumatoid arthritis. What is it?
Authors: Gordeev A. V. , Olyunin Yu. A. , Galushko E. A. , Zotkin E. G. , Lila A. M.
Published: October 2021

The widespread introduction into clinical practice of modern approaches to the treatment of rheumatoid arthritis (RA), the rational use of traditional and targeted antirheumatic drugs can effectively suppress inflammatory activity, restrain the progression of the disease and improve the quality of life of patients. At the same time, in some patients, even after the repeated change of targeted drugs, it is not possible to achieve the target level of RA activity. Serious difficulties arising in the management of such patients raised the question of identifying a special variant of the disease – difficult-to-treat (D2T) RA. The presence of various variants of D2T RA and the need to use a personalized approach to therapy justify the creation of special recommendations for the management of this category of patients. The first step in preparing these recommendations was the definition of D2T RA recently presented by the EULAR working group. It includes three criteria: 1) insufficient effectiveness of the therapy; 2) the presence of an active symptomatic disease; 3) clinical perception.
Netosis in the pathogenesis of antiphospholipid syndrome and systemic lupus erythematosus
Authors: Nurbaeva K. S. , Reshetnyak T. M. , Lila A. M.
Published: October 2021

Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are autoimmune diseases. In recent years, APS has been considered as an autoimmune thrombo-inflammatory disease. It has been established that clinical manifestations of APS can persist, progress over time, or debut during an adequate anticoagulant therapy and, in some cases, require administration of immunosuppressive drugs, which indicates the role of autoimmune inflammation in their development. The formation of extracellular neutrophil traps (neutrophil extracellular traps, NETs) is one of the connecting links of inflammation and thrombosis. Netosis is the process by which activated neutrophils in the extracellular space form netlike structures (NETs). This review examines the role of neutrophils and netosis in the pathogenesis of APS and SLE.
Management of the security of the logistics service providing companies in Colombia
Authors: Duran-Romero Danid Esther , Lechuga Cardozo Jorge Isaac , Guisao-Giraldo Erica Yaneth , Leyva-Cordero Oswaldo
Published: October 2021

El objetivo de este artículo es mostrar evidencia del estado en que se encuentra la gestión de seguridad en Operadores Logísticos en Colombia, en particular en la adopción de la Norma ISO 28000 y su certificación. Se definió un estudio cuantitativo de tipo analítico, descriptivo no experimental, transeccional y de campo. Se diseñó un instrumento, y se aplicó a una muestra de 13 empresas prestadoras de servicio logístico. Dicho cuestionario presenta 9 ítems para la variable conocimiento de iniciativas de gestión de seguridad, y 10 para el problema de la seguridad. Así, se evidenció que 1. los operadores logísticos reconocen como riesgos de seguridad, el hurto la piratería y el contrabando; 2. El 77% de las empresas encuestadas tienen noción de la Norma ISO 28000; 3. El total de los encuestados está certificado en Norma BASC, pero sólo el 43% certificado en ISO 28000, y 4. los operadores señalan como obstaculizadores de la implementación de la ISO 28000 el involucramiento con los proveedores y el cambio cultural en la organización. Se concluye que la muestra de operadores logísticos colombianos debe observar como oportunidad de mejora la implementación de la ISO 28000 y otras iniciativas como OEA (Operador Económico Autorizado) debido a la apertura comercial que vive el país y por ende la exigencia de los clientes internacionales por contar con proveedores certificados en la gestión integral de la seguridad en la cadena de abastecimiento.
Management conditions to generate impact on the productivity of health care institutions
Authors: Hernández Palma Hugo Gaspar , Pitre Redondo Remedios , Ossa Guerra Santander de la
Published: October 2021

Identificar las condiciones gerenciales que permitan generar impacto en la productividad de las instituciones prestadoras de servicios de salud (IPS). se centró en la recolección de información en torno a los diversos estilos gerenciales, para de este modo, determinar cómo estos se articulan a la productividad de las IPS, para ello, se identificaron los sistemas administrativos bajo el cual las IPS direccionan sus acciones, además, se determinó la concepción que estas entidades tienen acerca de la productividad y como la manejan. De acuerdo con los resultados, los estilos gerenciales están aunados a la productividad empresarial en la medida que estos afecten positiva o negativamente a sus colaboradores, por lo anterior, se concluye que es importante estructurar estrategias pertinentes que les permitan a las IPS hacer frente a los retos del mercado, a partir de una gestión integral.
Cheyne-Stokes Respiration in a 17-Year-Old Boy Awaiting Heart Transplantation
Authors: Rai Nooralam A. , De Aliva , Lamm Carin
Published: October 2021

Cheyne-Stokes respiration is a pattern of alternating central apnea and hyperpnea. It is well described in adults with congestive heart failure, but not in children.

We report the case of a 17-year-old boy whose systolic heart failure was complicated by Cheyne-Stokes respiration. He was given supportive therapy until heart transplant, after which his Cheyne-Stokes respiration clinically resolved. Clinicians should be aware of this uncommon condition in pediatric and adolescent patients who have advanced heart failure and irregular breathing.
SOILomics; where Microbiome Genetics meets Precision Agriculture
Authors: Vlachakis Dimitrios , Efthimiadou Aspasia
Published: October 2021

Advances in genetics, soil biochemistry and microbiome analysis are opening up a new era in Precision Agriculture. In this direction, new techniques bring groundbreaking changes in land management practices through direct or indirect management of soil microbial communities. There is huge demand for the protection and enhancement of soil health and climate change resilience of crops. The increase in population, food consumption and fast approaching climate change pose a new threat to mankind that only by being proactive and highly prepared to deploy all novel and innovative stratagems in state-of-the-art soil microbiome precision agriculture can be avoided.
A bíboros legátusok kancelláriái a 14. században
Authors: Jugie Pierre
Published: October 2021

From 1305 to 1378, the popes involved in 64 missions 40 cardinals (that is 26,7% of the members of the Sacred College of that period), either as legate (41%), or as legate and vicar general on the Papal States (7%), or only as nuncio (35%), excluding the vicars generals who were neither legate nor nuncio. In a (temporary) synthesis are studied the composition and the working of the legatine chanceries: the functions and the value of the chancellors, their relations with the judiciary court of the cardinal’s curia (audientia causarum curie); the various members of the chancery, notaries, secretaries, abbreviatores, scribes, registratores and all the familiares working in the „writing offices” of cardinals. On the other hand, the relations between the legatine chanceries and other chanceries (specially papal and royal ones) are observed in order to see their reciprocal influence and the effects on the development of the papal diplomacy. Two tables are proposed in appendix, a chronological table of all missions of these cardinals from 1305 to 1378 and a synthetic table of the members of the „writing offices” during legations and nunciatures or nor.
Ankle Proprioception in Male and Female Surfers and the Implications of Motor Experience and Lower-Body Strength
Authors: Dowse Rebecca A. , Secomb Josh L. , Bruton Michaela , Parsonage Joanna , Ferrier Brendon , Waddington Gordon , Nimphius Sophia
Published: October 2021

Dowse, RA, Secomb, JL, Bruton, M, Parsonage, J, Ferrier, B, Waddington, G, and Nimphius, S. Ankle proprioception in male and female surfers and the implications of motor experience and lower-body strength. J Strength Cond Res 36(12): 3497–3504, 2022—The primary objectives were to evaluate if the active movement extent discrimination apparatus (AMEDA) condition (i.e., front foot and back foot plantarflexion, dorsiflexion, inversion, and eversion) and the level of competition explained ankle movement discrimination scores and, thereafter, examined the contribution of surf experience, physical capacity, and ability to proprioception. It was also considered important to re-evaluate the surf experience, anthropometric characteristics, physical capacities, and abilities of male and female surfers. Twenty-six male (n = 12, surf experience = 18 ± 8 years) and female surfers (n = 14, surf experience = 9 ± 6 years) completed a pre-exercise medical questionnaire, anthropometric assessment, 8 AMEDA assessments, countermovement jump, squat jump, and isometric midthigh pull assessment. The AMEDA condition and level of competition did not have a statistically significant main effect on ankle movement discrimination scores; however, the effect of the gender/sex was significant (p = 0.044). Surf experience (p = 0.029) and lower-body isometric strength (p = 0.029) had a statistically significant but small main effect on ankle movement discrimination scores. The results also confirmed that there were significant differences in surf experience, anthropometric characteristics, physical capacity, and jumping ability between male and female surfers. As surf experience and physical capacity were only able to explain a small magnitude of ankle movement discrimination scores, it is suggested that ankle proprioception in surfers may be related to both the volume and quality of the motor experience attained, which may be augmented by environmental and sociocultural factors.
The Axiom of High Modernism
Authors: Steingart Alma
Published: October 2021

This essay follows the influence of axiomatic thinking on American intellectual thought at midcentury. I demonstrate how in the postwar period axiomatic analysis moved from mathematics into the social sciences and in the process redefined the meaning of theoretical knowledge. Axiomatics fostered a belief that theories do not emerge from first principles and that analytic coherence precedes empirical verification. It emphasized structural analysis and propagated the ideal of an economy of thought. Most fundamentally, it helped define what a social scientific theory is. By the 1970s the association between axiomatics and theoretical knowledge was so strong that it was also evident in the work of architects and designers.
Al ritmo de la marea: caracterización del paisaje acústico de la zona costera de Punta Morales, Puntarenas, Costa Rica
Authors: Portuguez-Brenes Ian , Vargas-Masís Roberto , Perdomo-Velázquez Héctor , García-Rojas Andrea
Published: October 2021

En los ecosistemas costeros, las geofonías forman parte fundamental del entorno acústico y el impacto del oleaje sobre su geomorfología es un ejemplo de ello. Se colocó una grabadora Audiomoth en cuatro sitios de Punta Morales, Puntarenas, Costa Rica, del 22 de noviembre al 18 de diciembre, 2020. Se programaron para registrar 60 segundos cada 10 minutos durante 24 horas con el objetivo de caracterizar el paisaje acústico asociado al ciclo de mareas de la localidad. De las grabaciones obtenidas, se analizaron: el Índice de Diferencia Normalizada del Paisaje Sonoro (NDSI), las Tecnofonías, la Entropía Acústica (TE) y el Nivel de Presión Sonora (SPL). Estos valores se contrastaron entre sitios mediante un análisis de medias recortadas unidireccionales; se realizó una correlación entre el SPL y el nivel de marea en cada lugar y, por último, se compararon los valores en un mismo punto de muestreo entre pleamar y bajamar. Se encontraron diferencias en todas las comparaciones realizadas; además, en dos sitios se identificó una correlación positiva y se observaron diferencias de SPL entre pleamar y bajamar. El sustrato y la vegetación de cada lugar pudieron influir en estas diferencias. Asimismo, el oleaje modifica la dinámica acústica de algunos sectores significativamente, por lo que pudo haber afectado el paisaje sonoro de esta zona costera.
ВИКОРИСТАННЯ АЛГОРИТМІВ ШТУЧНОГО ІНТЕЛЕКТУ У ГАЛУЗІ КРИМІНАЛЬНОГО СУДОЧИНСТВА: МІЖНАРОДНИЙ ДОСВІД ТА ВІТЧИЗНЯНІ ПЕРСПЕКТИВИ
Authors: Демура Марина , Клепка Дар`'я
Published: October 2021

Вступ. Наразі світ переживає чергову технологічну революцію, ключовим елементом якої є передача, обробка та використання інформації. Одним з напрямів такої революції є розвиток та застосування у різних галузях науки штучного інтелекту (ШІ).
Проблематика. Міжнародний досвід використання алгоритмів штучного інтелекту у галузі кримінального судочинства та національні перспективи його використання.Мета. Дослідження міжнародного досвіду використання алгоритмів ШІ у галузі кримінального судочинства та визначення можливих напрямів впровадження таких технологій у вітчизняний кримінальний процес.Матеріали й методи. Методологічною основою слугували діалектичний, системний, логічний методи, а також метод порівняльного правознавства.Результати. Аналіз національного та зарубіжного кримінального процесуального законодавства, а також практики використання ШІ показав можливості використання алгоритмів ШІ у галузі кримінального судочинства. Доведено, що, враховуючи міжнародний досвід, запровадження використання алгоритмів ШІ у кримінальному провадженні України має не тільки свої перспективи, а в деяких випадках навіть є необхідним інструментом забезпечення прав та законних інтересів учасників кримінального провадження. Найважливішим при цьому залишається питання дотримання прав особи під час використання алгоритмів ШІ, а також забезпечення справедливого судового розгляду з тим, щоб кожний, хто вчинив кримінальне правопорушення, був притягнутий до відповідальності в міру своєї вини, жоден невинуватий не був обвинувачений або засуджений, жодна особа не була піддана необґрунтованому процесуальному примусу і щоб до кожного учасника кримінального провадження була застосована належна правова процедура.Висновки. Використання ШІ може суттєво зменшити навантаження як на органи досудового розслідування, прокуратуру, так і на судову систему загалом. Окрім належного технічного забезпечення використання алгоритмів ШІ у кримінальному провадженні України, необхідним є також запровадження належного та якісного нормативного регулювання використання таких технологій у кримінальному провадженні.
The Impact of Calcium on Chronic Total Occlusion Management
Authors: Cosgrove Claudia , Mahadevan Kalaivani , Spratt James C , McEntegart Margaret
Published: October 2021

Coronary artery calcification is prevalent in chronic total occlusions (CTO), particularly in those of longer duration and post-coronary artery bypass. The presence of calcium predicts lower procedural success rates and a higher risk of complications of CTO percutaneous coronary intervention. Adjunctive imaging, including pre-procedural computed tomography and intracoronary imaging, are useful to understand the distribution and morphology of the calcium. Specialised guidewires and microcatheters, as well as penetration, subintimal entry and luminal re-entry techniques, are required to cross calcific CTOs. The use of both atherectomy devices and balloon-based calcium modification tools has been reported during CTO percutaneous coronary intervention, although they are limited by concerns regarding safety and efficacy in the subintimal space.
Government mechanisms in the activities of the National Guard of Ukraine: an organizational and legal approach
Authors: Midina Anastasia , Orel Oksana
Published: October 2021

The article is devoted to a comprehensive study of the organizational and legal foundations of public administration mechanisms in the activities of the National Guard of Ukraine. The arsenal of features of the mechanisms of state administration is outlined both in the executive authorities in general and in the National Guard of Ukraine in particular. It is noted, that it is advisable to consider these features as forms of ensuring their activities. Namely: organizational and structural, regulatory and legal, theoretical and methodological, and the like.
The scientific approach to the classification of factors of influence and characteristics of personnel management (personnel of the National Guard of Ukraine) as a powerful potential of our country has been improved. By the nature of the managerial impact, the following factors have been identified: direct (legal regulation, public administration) and indirect (democratization, management optimization, etc.) factors. In terms of functional content - organizational and legal, motivational, innovative, social, financial.
Attention is focused on the factors of influence and the features of personnel management (personnel of the National Guard of Ukraine) as a powerful potential of our country. Namely, the author's vision of the general principles of the National Guard of Ukraine as a subject of countering threats to the national security of Ukraine has been formulated by defining: “The National Guard of Ukraine, being a participant in legal relations in the field of countering threats to the national security of Ukraine, carries out activities, regulated by the norms of military, public and administrative law, is based and changes depending on public and administrative legal regimes; has the powers, defined by law to identify, prevent, destroy and reduce the negative impact of the aggressor”
Climate adaptive agricultural extension approaches for putting research into use
Authors: Balakrishnan Dhanusha , Chandran Vani , Seema B. , Paul Preethu K.
Published: October 2021

The reality of climate change is harsh and it’s a bitter truth for most of our farmers. In the present situation, climate change is one of the most important challenges to food security. Pertinent actions are, therefore, needed to address these challenges to enable the agricultural sector to significantly contribute to the attainment of agriculture development. Climate adaptive agricultural approach is an approach for developing agricultural strategies to secure sustainable food security under climate change. Through CAA the quality and quantity of agricultural production can be increased and production costs can be decreased. For example, with climatologically data it is also possible to recognize bad weather conditions and to be more prepared to minimize the damage. Many projects have recently adopted with the idea of climate smart agriculture for mitigating the challenges of climate change. With the help of suitable extension approaches we can effectively disseminate various climate smart agricultural practices to farming community.
Character association studies in turmeric (Curcuma longa L.)
Authors: Harish B. S. , Umesha K. , Halesh G. K. , Janardhan G.
Published: October 2021

Turmeric (Curcuma longa L.) is an important spice crop being grown in India belongs to the family Zingiberaceae. Experiment was conducted in a farmer’s field of Mysuru district in Karnataka for two growing seasons and ‘IISR Prathibha’ variety was used. Correlation co-efficients were worked out for the various growth, physiological, yield and quality parameters. Highly significant and positive association of plant height (0.91), number of leaves (0.89), number of tillers (0.86), secondary rhizome weight (0.81), mother rhizome weight (0.80), chlorophyll content (0.71), mother rhizome number (0.64), leaf area (0.62), leaf area index (0.62) and primary rhizome weight (0.52) with fresh rhizome yield was observed. A significant and negative correlation was observed for ar-turmerone content with PAL activity (-0.43) and curcumin content (-0.39). Between the SPAD values and the curcumin content, the association was highly significant and positive (0.55).
Death and dying of newborns and children: relationships between nursing and family according to Travelbee
Authors: Medeiros Jocellem Alves de , Almeida Júnior José Jailson de , Oliveira Luciane Paula Batista Araújo de , Silva Flávia Rayonara Santana da , Silva Clara Caroline dos Santos , Barros Wanessa Cristina Tomaz dos Santos
Published: October 2021

ABSTRACT Objective: Identify the nursing staff's perception of their relationship with families of newborns and children who are in the process of death and dying. Methods: Qualitative research, carried out in the Neonatal and Pediatric Intensive Care Unit of a public maternity hospital in Rio Grande do Norte, with 17 nursing professionals, through a semi-structured interview. After being transcribed, the data were subjected to Bardin's content analysis and interpreted in the light of the theory of Interpersonal Relations proposed by Travelbee. Results: Four categories emerged from the analysis: "Caring and welcoming people, feelings and stories"; "Reactions in the midst of pain: moving between acceptance and suffering"; "Communication of bad news: challenges and strategies"; "The weight of caring and suffering". Final considerations: Family assistance can be established using Travelbee's principles, as they offer timely theoretical support for nursing actions in the context of the process of death and dying.
La práctica online del budismo en tiempos de pandemia: rituales, comunidad y mediatización
Authors: Carini Catón Eduardo
Published: October 2021

Resumen: Desde fines del año 2019 la población mundial se ha visto convulsionada por la irrupción de un virus previamente desconocido que se esparce rápidamente y cobra miles de víctimas fatales cada día. Muchos países del globo han cerrado sus fronteras y decretado la cuarentena o aislamiento social preventivo, trastocando la vida cotidiana de la comunidad internacional de una forma nunca antes vista. En este contexto, se ha visto incrementado el uso de las nuevas tecnologías digitales de comunicación a distancia como forma de continuar con actividades hasta hace poco realizadas presencialmente, tales como el trabajo, el estudio, las relaciones sociales y la práctica de la religión. En este trabajo exploramos las mudanzas observadas en el empleo de internet en el marco de grupos budistas de la Argentina debido a la crisis generada por el Covid-19, indagando especialmente en la creación de nuevos rituales online y la construcción de un sentimiento de comunidad que atraviesa las fronteras locales, nacionales y globales.
Estimated prevalence of COVID-19 in Brazil with probabilistic bias correction
Authors: Figueiredo Erik Alencar de , Polli Démerson André , Andrade Bernardo Borba de
Published: October 2021

Abstract: Using data collected by the Brazilian National Household Sample Survey - COVID-19 (PNAD-COVID19) and semi-Bayesian modelling developed by Wu et al., we have estimated the effect of underreporting of COVID-19 cases in Brazil as of December 2020. The total number of infected individuals is about 3 to 8 times the number of cases reported, depending on the state. Confirmed cases are at 3.1% of the total population and our estimate of total cases is at almost 15% of the approximately 212 million Brazilians as of 2020. The method we adopted from Wu et al., with slight modifications in prior specifications, applies bias corrections to account for incomplete testing and imperfect test accuracy. Our estimates, which are comparable to results obtained by Wu et al. for the United States, indicate that projections from compartmental models (such as SEIR models) tend to overestimate the number of infections and that there is considerable regional heterogeneity (results are presented by state).
DOES THE DROP IN PORTAL PRESSURE AFTER ESOPHAGOGASTRIC DEVASCULARIZATION AND SPLENECTOMY INFLUENCE THE VARIATION OF VARICEAL CALIBERS AND THE REBLEEDING RATES IN SCHISTOSOMIASIS IN LATE FOLLOW-UP?
Authors: SILVA-NETO Walter de Biase , QUIRESE Claudemiro , MOURA Eduardo Guimarães Horneaux de , COELHO Fabricio Ferreira , HERMAN Paulo
Published: October 2021

ABSTRACT Background: The treatment of choice for patients with schistosomiasis with previous episode of varices is bleeding esophagogastric devascularization and splenectomy (EGDS) in association with postoperative endoscopic therapy. However, studies have shown varices recurrence especially after long-term follow-up. Aim: To assess the impact on behavior of esophageal varices and bleeding recurrence after post-operative endoscopic treatment of patients submitted to EGDS. Methods: Thirty-six patients submitted to EGDS were followed for more than five years. They were divided into two groups, according to the portal pressure drop, more or less than 30%, and compared with the behavior of esophageal varices and the rate of bleeding recurrence. Results: A significant reduction on the early and late post-operative varices caliber when compared the pre-operative data was observed despite an increase in diameter during follow-up that was controlled by endoscopic therapy. Conclusion: The drop in portal pressure did not significantly influence the variation of variceal calibers when comparing pre-operative and early or late post-operative diameters. The comparison between the portal pressure drop and the rebleeding rates was also not significant.
ARE STEM CELL MARKER EXPRESSION AND CD133 ANALYSIS RELEVANT TO DIFFERENTIATE COLORECTAL CANCER?
Authors: CZECZKO Leticia Elizabeth Augustin , RIBAS Carmen Australia Paredes Marcondes , CZECZKO Nicolau Gregori , SKARE Thelma Larocca , YAMAKAWA Camila Kienen , GIONEDIS Guilherme , VASCONCELOS Cecilia , BREMER Fabiola Pabst , CASTOLDI Diogo Francesco , GASSER Martin , WAAGA-GASSER Ana Maria
Published: October 2021

ABSTRACT Background: CD133 and AXL have been described as cancer stem cell markers, and c-MYC as a key regulatory cellular mechanism in colorectal cancer (CRC). Aim: Evaluate the prognostic role of the biomarkers CD133, AXL and c-MYC and their association with clinicopathologic characteristics in colorectal adenocarcinomas and adenomas. Methods: A total of 156 patients with UICC stage I-IV adenocarcinomas (n=122) and adenomas (n=34) were analyzed. Tissue microarrays (TMA) from primary tumors and polyps for CD133, c-MYC and AXL expression were performed and analyzed for their significance with clinicopathologic characteristics. Results: Poorly differentiated adenocarcinomas and disease progression were independent risk factors for poor overall survival. The median overall survival time was 30 months. Positive CD133 expression (35.9% of all cases), particularly of right-sided CRCs (44.8% of the CD133+ cases), was negatively correlated with death in the univariate analysis, which did not reach significance in the multivariate analysis. c-MYC (15.4% of all cases) was predominantly expressed in advanced-stage patients with distant (non-pulmonary/non-hepatic) metastasis. AXL expression was found only occasionally, and predominantly dominated in adenomas, with less penetrance in high-grade dysplasia. Conclusions: CD133 expression was not associated with inferior overall survival in CRC. While AXL showed inconclusive results, c-MYC expression in primary CRCs was associated with distant metastasis.
FEMORAL HERNIA: UNCOMMON, BUT ASSOCIATED WITH POTENTIALLY SEVERE COMPLICATIONS
Authors: COELHO Julio Cezar Uili , HAJAR Faissal Nemer , MOREIRA Gabriela Araujo , HOSNI Andréa Virmond El , SAENGER Bruna Freitas , AGUILERA Yan Sacha Hass , COSTA Marco Aurelio Raeder da , CLAUS Christiano Marlo Paggi
Published: October 2021

ABSTRACT Background: Although the laparoscopic access is becoming the preferable treatment for femoral hernia, there are only few studies on this important subject. Aim: To assess the outcomes of the totally extraperitoneal laparoscopic (TEP) access in the treatment of femoral hernia. Methods: Data of 62 patients with femoral hernia who underwent herniorrhaphy were retrospectively reviewed. The diagnosis of femoral hernia was established by clinical and/or imaging exams in 55 patients and by laparoscopic findings in seven. Results: There were 55 (88.7%) females and 7 (11.3%) males, with female to male ratio of 8:1. The mean age was of 58.9±15.9 years, ranging from 22 to 92 years. Most patients (n=53; 85.5%) had single hernia and the remaining (n=9; 14.5%) bilateral, making a total of 71 hernias operated. Prior lower abdominal operations were recorded in 21 (33.9%) patients. Conversion to laparoscopic transabdominal preperitoneal procedure was performed in four (6.5%). Open herniorrhaphy was needed in two (3.2%), one with spontaneous enterocutaneous fistula in the groin region (Richter’s hernia) and the another with incidental perforation of the adjacent small bowel that occurred during dissection of hernia sac. There was no mortality. Conclusion: Femoral hernia is uncommon, and it may be associated with potentially severe complications. Most femoral hernias may be successfully treated with totally extraperitoneal laparoscopic access, with low conversion and complication rates.
Distúrbios Ondulatórios de Leste no Nordeste Brasileiro: Um Estudo de Caso Utilizando Modelagem Numérica de Mesoescala
Authors: Silva Alex Soares da , Silva Emerson Marino da , Leal Junior João Bosco Verçosa , Sales Domingo Cassain , Moura Icaro Jael Mendonça , Alves José Maria Brabo
Published: October 2021

Resumo Os Distúrbios Ondulatórios de Leste (DOLs) são um dos principais sistemas meteorológicos que atuam no leste do Nordeste do Brasil (NEB) entre maio e julho. O presente estudo tem como objetivo investigar os impactos das diferentes técnicas de nudging na simulação de DOLs utilizando o modelo regional Weather Research and Forecasting (WRF) a partir de três diferentes tipos de simulação, alternando entre elas diversas possibilidades do uso desta técnica: (1) utilizando o nuding de forma desligada (WRF-DF), (2) usando a técnica Analysis Nuding (WRF-AN), e (3) usando a técnica Spectral Nudging (WRF-SN). As variáveis analisadas foram a precipitação e o vento de dois episódios de DOLs que atingiram o NEB entre os dias 12 e 14 de junho de 2019. Os resultados foram comparados à reanálise do ERA-Interim e imagens dos satélites GOES 16 e METEOSAT 10. De acordo com os resultados, a simulação WRF-SN representou melhor a terceira e quarta onda dos eventos estudados, enquanto a simulação WRF-AN descreveu melhor a distribuição espaço-temporal da precipitação. A simulação WRF-DF apresentou resultados similares aos da WRF-SN. Isso indica que a utilização da técnica Spectral Nudging, apenas acima da camada limite planetária (CLP), não influencia de maneira expressiva o comportamento dos ventos ou o número de onda escolhido não é adequado para estudar os DOLs. Já a simulação WRF-AN apresentou resultados semelhantes ao da reanálise do ERA-Interim, podendo estar relacionado ao coeficiente de nudging escolhido.
Redes sociais e configurações de equipes em uma unidade da Atenção Primária à Saúde do município do Rio de Janeiro
Authors: Silva Tarciso Feijó da , Ramos Tatiana Cabral da Silva , David Helena Maria Scherlowski Leal
Published: October 2021

RESUMO O trabalho em equipe é um pré-requisito da Atenção Primária à Saúde para cumprimento do seu papel de ordenadora e coordenadora do cuidado. O objetivo do estudo foi identificar por meio das relações entre os profissionais, a configuração das diferentes equipes que atuam em uma unidade da Atenção Primária à Saúde do município do Rio de Janeiro, tomando como base a Análise de Redes Sociais para a produção das redes ativas no momento do estudo. Utilizou-se essa abordagem por permitir identificar o mapeamento do fluxo da informação e troca, os padrões de comunicação entre os profissionais e representar graficamente as conexões existentes entre diferentes atores. As equipes que atuam na unidade organizam seu trabalho cotidiano em formatos de redes diversos, o que permitiu compreender a dinâmica de comunicação, organização, trabalho em equipe e produção do cuidado no seu aspecto relacional. Considera-se que distintas modelagens de equipe podem ditar o processo de trabalho nesse ponto da rede, fragilizando ou potencializando suas ações, a depender do envolvimento de cada ator, da posição deles na rede e dos recursos que acionam para produção do cuidado.
O perfil das tecnologias em saúde incorporadas no SUS de 2012 a 2019: quem são os principais demandantes?
Authors: Rodrigues Filho Francisco José , Pereira Michelly Cristiny
Published: October 2021

RESUMO As tecnologias em saúde têm revolucionado a assistência médica e a gestão em saúde. A Comissão Nacional de Incorporação de Tecnologias no SUS (Conitec) é o órgão do Ministério da Saúde que assessora na incorporação, exclusão ou alteração de novas tecnologias no Sistema Único de Saúde (SUS). O presente estudo objetivou descrever o perfil das tecnologias incorporadas no SUS de 1 de janeiro de 2012 a 30 de setembro de 2019. Os dados foram coletados no site da Conitec. Na análise estatística, foi utilizado o teste Qui-quadrado de Pearson e o Teste Exato de Fisher. Os resultados demonstram que foram incorporadas 380 tecnologias, prevalecendo os medicamentos (46,6%). Em relação aos demandantes, os de origem interna superaram os demais (82,4%), principalmente secretarias do Ministério da Saúde (p<0,001). As Doenças Infecciosas e Parasitárias (DIPs) foram as mais beneficiadas (20,3%), com destaque para o HIV (Vírus da Imunodeficiência Humana). A maioria das tecnologias incorporadas passou por consulta pública (p<0,001). Conclui-se que o perfil das tecnologias incorporadas são principalmente medicamentos, por demanda interna, com indicação para DIPs e, sobretudo para o HIV. Os medicamentos continuam sendo o foco das solicitações e as demandas internas passaram a ter mais espaço nesse cenário.
Exposição ‘Zika Vidas que Afetam’: um relato de experiência
Authors: Silva Lenir , Albuquerque Mariana , Mayrink Marta Fabíola
Published: October 2021

RESUMO A epidemia do vírus Zika, que atingiu o Brasil entre 2015 e 2018, afetou, sobretudo, mulheres e crianças, mobilizando respostas da ciência, sociedade e governos. A Rede Zika Ciências Sociais promoveu a exposição ‘Zika Vidas que Afetam’, mostra inédita para os 120 anos da Fundação Oswaldo Cruz (Fiocruz). O objetivo desse relato foi trazer a experiência da construção da exposição, com destaque para a contribuição das mulheres - mães, gestoras, profissionais de saúde e pesquisadoras. A exposição é um dispositivo de divulgação científica construído coletivamente, entre outubro de 2018 e agosto de 2020. O método envolveu a participação, por meio de entrevistas, oficinas e reuniões, de representantes dos vários grupos e instituições afetados pela epidemia: cientistas, usuários, profissionais e gestores da saúde. Tal participação ocorreu desde a concepção, produção, finalização, validação e readequação da exposição à versão on-line, no contexto da pandemia de Covid-19. Os resultados mostram as potencialidades e os desafios do modo de construção coletiva - uma experiência que pode afetar outras experiências. A narrativa da exposição é feita majoritariamente por mulheres, sob diferentes pontos de vista, a partir das questões que as afetam, e evidencia o seu papel destacado na mobilização e resposta à Zika, na ciência, na política e na sociedade.
Revolução budista ou apocalipse zumbi? Discussões sobre mindfulness a partir de uma perspectiva gestáltica
Authors: Pereira Fabio Nogueira , Dalgolbo Carla Gomes , Silva Monalisa Oliveira da
Published: October 2021

Resumo A busca por práticas meditativas orientais como tecnologia promotora de saúde e qualidade de vida tem aumentado significativamente nos últimos anos. Contudo percebe-se que a falta de compreensão dos conceitos e princípios dos quais emergem tais técnicas produzem propostas que podem ser tanto uma saída revolucionária quanto distópica. Propomos neste texto uma breve discussão sobre o movimento de mindfulness a partir de uma perspectiva gestáltica de influência goodmaniana. Assim, (a) apresentamos de maneira resumida a transmissão destas práticas desde tradições budistas até a ciência ocidental contemporânea; (b) destacamos alguns aspectos teóricos que aproximam e distanciam a Gestalt-terapia de pressupostos budistas; e (c) discutimos a apropriação dessas tradições, seus valores e suas tecnologias por um paradigma neoliberal utilitarista.
A teoria do desenvolvimento maturacional de Winnicott: novas perspectivas para a educação
Authors: Almeida Alexandre Patricio de , Naffah Neto Alfredo
Published: October 2021

O artigo pretende discutir as contribuições da teoria do desenvolvimento maturacional de Winnicott para o campo da educação escolar. De início, é apresentado ao leitor um breve histórico freudiano a respeito da questão da psicanálise aplicada. Em seguida, articulamos pontos centrais da teoria winnicottiana com aspectos específicos do contexto pedagógico. Por último, sem o objetivo de esgotar o tema, lançamos possíveis provocações sobre a necessidade de a psicanálise ser articulada com outras esferas das ciências humanas.
Impactos da robótica no ensino básico: estudo comparativo entre escolas públicas e privadas
Authors: Andriola Wagner Bandeira
Published: October 2021

Resumo: Objetivou-se avaliar familiaridade e expectativas de alunos do Ensino Fundamental de escolas particulares e públicas acerca da Robótica Educacional, compreendida como estratégia de ensino de caráter interdisciplinar, desafiadora e lúdica, voltada a promover a aprendizagem de conceitos curriculares. Empregou-se amostra de 161 alunos cursando da 6ª à 9ª séries, com idades entre 10 e 17 anos. Os resultados indicaram que a expressiva maioria dos alunos opinou (i) ser muito relevante ter um laboratório destinado ao ensino da Robótica Educacional; (ii) estar muito motivado para novos aprendizados; (iii) ter muita curiosidade para desenvolver autômatos; (iv) considerar importante a Robótica para o aprendizado de outros conteúdos curriculares e para incentivar o trabalho em grupo com colegas de classe. Portanto, a introdução da Robótica Educacional em processos de ensino de áreas e disciplinas mais ‘duras’, possibilitará incrementar nos alunos a motivação, a curiosidade e a aprendizagem de conteúdos curriculares das ciências básicas.
Estrategias evaluativas para promover la autorregulación del aprendizaje de Biología en estudiantes de primer año universitario
Authors: Garofalo Sofia Judith , Miño Mariela Haidee
Published: October 2021

Resumen: Se describe y analiza la implementación de actividades de autoevaluación y evaluación colaborativa con diario de aprendizaje (DA) como estrategia de enseñanza para la metacognición y autorregulación del aprendizaje en estudiantes de Biología de primer año universitario. Nos propusimos analizar estrategias autorreguladoras (EA), describir procesos feedback y feedforward en las intervenciones docentes durante coevaluaciones usando el DA y analizar si hay relación entre las EA de estudiantes que hicieron el DA y aquellos que no, respecto al logro académico alcanzado. Logramos identificar, categorizar y describir EA de planificación (al inicio), EA con base en la evaluación de resultados (con los exámenes) y EA de control (durante las interacciones docentes). Los resultados obtenidos pusieron de manifiesto que el grupo de estudiantes con guía del docente para promover la metacognición usando el DA obtuvo mejor logro académico en la materia, adquiriendo mayor autonomía autorreflexiva y autocrítica de sus aprendizajes.
Bioética e interculturalidade na atenção à saúde indígena
Authors: Melo Aislan Vieira de , Sant’Ana Graziella Reis de , Bastos Paulo Roberto Haidamus de Oliveira , Antônio Leosmar
Published: October 2021

Resumo Este artigo aponta aspectos socioculturais, teóricos e jurídicos para uma bioética intercultural na atenção à saúde dos povos indígenas do Brasil. A partir de uma perspectiva que busca construir práticas bioéticas adequadas aos encontros entre culturas, o texto argumenta que o foco em tecnologias leves de saúde pode ser um caminho para superar as dificuldades encontradas em um contexto permeado pela colonialidade e o racismo estrutural. Algumas experiências de prática bioética intercultural são apresentadas no artigo. Essas experiências, apesar de se referirem ao contexto brasileiro, podem ser aplicadas em outros cenários de encontro entre diferentes culturas.