bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of urokinase, T-cadherin and adiponetin in the development of endogenous depressive disorders
Authors: Sheleg D. A. , Karagyaur M. N. , Primak A. L. , Neyfeld E. A.
Published: July 2023

Introduction The prevalence of depression averages approximately 6 % of the total population. The heritability of depression ranges from 28 % to 44 %. Genetic predisposition may be due to polymorphisms of genes involved in the processes of functioning and morphogenesis of the brain: the balance of monoamines, the action of navigational molecules and their receptors.

Purpose of the study To determine the role of genes that regulate the processes of nerve cell migration and directed growth of nerve fibers of navigation receptors (PLAUR and CDH13) or their ligands (PLAU, PLAT, ADIPOQ) in the development of endogenous depression and schizophrenia in the Russian population.

Materials and methods At the first stage of the study, the scientific literature was searched in the MEDLINE database. The primary prevalence of genomic variants will be established using whole genome sequencing of 20 patients with severe forms of schizophrenia and endogenous depression. Further, at least 100 patients in each group and 100 healthy donors will take part in the study.

Results and discussion The urokinase receptor (uPAR) is involved in neurogenesis by regulating the trajectory of axonal growth. The level of suPAR in blood plasma can act as a biomarker of mild inflammation underlying the etiology of depression. The level of suPAR in plasma can be considered a predictor of the effectiveness of combination therapy with antidepressants and anti-inflammatory drugs. Molecules of the cadherin superfamily are involved in the development of the nervous system, the transmission of intercellular signals, and the regulation of neuronal plasticity. Polymorphisms of the CDH7, CDH9, CDH13, CDH17 genes demonstrate a correlation with the presence of depression. Adiponectin is a hormone secreted by adipose tissue. One of the adiponectin receptors, AdipoR2, stimulates neuronal plasticity and inhibits inflammation and oxidative stress. Plasma concentrations of adiponectin are reduced in depressed patients.

Conclusion The results accumulated by researchers testify in favor of the important role of uPAR and T-cadherin in the processes of brain development, and most importantly, in the pathogenesis of the development of endogenous depressions.
Estudos de características produtivas e medidas morfométricas de ovino de raça Santa Inês, usadas como critério de seleção.
Authors:   , de Farias Ramos Daniel
Published: July 2023

Este trabalho teve como objetivo fazer um estudo da influência de fatores que afetam características produtivas e medidas morfométricas de ovinos da raça Santa Inês, participantes de exposição agropecuária, além de estimar coeficientes de correlação entre as características. Essas informações são primordiais para serem usadas como um possível critério de seleção, permitindo assim melhorar a raça e aumentar a produção animal. Foram analisadas, características de peso, ganho de peso e medidas morfométricas (comprimento corporal, altura do posterior, altura do anterior, perímetro torácico e circunferência escrotal) de 137 ovinos da raça Santa Inês, destes, 106 Fêmeas e 31 machos, todos nascidos no período de 2006 a 2009, com idade variando de 4 a 36 meses, oriundos de 24 fazendas. Foi feita uma análise de variância utilizando o método de máxima verossimilhança restrita, pelo procedimento PROC MIXED do Statistical Analysis System (SAS), 2006 (versão 9.3). Os coeficientes de correlação de Pearson entre as características estudadas foram estimadas pelo procedimento CORR do SAS. A análise dos dados demostrou diferença significativa (P<0,01) para o efeito do sexo em todas as características. O mês de nascimento não influenciou em nenhuma das características avaliadas, exceto no ganho de peso diário do animal (P<0,05). O efeito da fazenda foi significativo (P<0,05) para as características de peso, ganho de peso diário e comprimento do animal. O ano de nascimento influenciou significativamente as características de peso (P<0,01), comprimento (P<0,01), altura do posterior (P<0,05) e altura do anterior (P<0,01). Houve diferença significativa para o efeito da idade nas características peso, ganho de peso diário e comprimento e altura do anterior do animal. As características de perímetro torácico e circunferência escrotal não tiveram influencia em nenhuma das fontes de variação analisadas. As correlações genéticas entre o peso dos animais e as medidas morfométricas estudadas e as correlações das medidas entre si foram todas positivas de moderada a alta. O perímetro torácico foi à medida mais correlacionada com o peso do animal. O ganho de peso diário apresentou correlação negativa com todas as características estudadas. O peso e o ganho de peso estão mais sujeitos a influência de fatores ambientais. Portanto, todas essas características analisadas nesse trabalho podem ser usadas como auxilio na determinação de critérios de seleção da raça ovina Santa Inês.
Análise técnico-econômica da implantação de placas fotovoltaicas em uma usina de beneficiamento de leite caprino.
Authors:   , Onasses Pereira de Araujo Lima Francis
Published: July 2023

A região Nordeste do nosso país, em especial o Cariri Paraibano, permite que a implementação de projetos fotovoltaicos promova significativos ganhos sociais e econômicos. O crescente uso das placas fotovoltaicas para agroindústria justifica a necessidade de gerenciamento de projetos, que pode ser definido como o processo técnico de criação de algo novo com o objetivo de facilitar, melhorar e garantir a qualidade final do produto. Foram abordados nesse presente trabalho os processos de dimensionamento e implantação do sistema (On-grid), promovendo uma visão mais abrangente de como é seu funcionamento através de uma breve revisão de literatura. Também foi realizada uma revisão dos principais temas de gestão de projetos, para se ter uma noção da importância da existência de um projeto prévio a um investimento e, dentro deste contexto, utilizamos duas técnicas de análise de investimento para avaliar o projeto de implementação do sistema fotovoltaico: payback simples e payback descontado. O projeto de implantação das placas fotovoltaicas na usina de beneficiamento de leite de caprino da Prata apresentou significativas vantagens econômicas, em especial em relação ao baixo tempo de retorno do investimento frente à vida útil do sistema projetado.
Modelo multicritério para estratégia de plantio sustentável em propriedades rurais.
Authors:   , de Souza Nogueira Jordana
Published: July 2023

Em pequenas propriedades rurais, os agricultores costumam ter restrições financeiras e de espaço, o que traz a necessidade de otimizar recursos para o melhor aproveitamento da cultura. Além disso, a agricultura tradicional promove diversos problemas, como degradação e diminuição da produtividade. Nesse sentido, o plantio sustentável, que engloba os três pilares da sustentabilidade (social, financeiro e ambiental), concilia o cuidado com o meio ambiente com a preocupação com a produtividade, tornandose uma saída para promover melhorias monetárias com políticas de proteção ambiental para os agricultores. Dessa forma, a presente pesquisa propõe um modelo multicritério de apoio a decisão que emprega o PROMETHEE II para determinar estratégia de plantio sustentável em propriedades rurais. O modelo proposto define quais estratégia de plantio o agricultor deve utilizar, considerando diversos critérios relacionados aos pilares da sustentabilidade. Neste contexto, observase como principais vantagens da sistemática: tomada de decisão estruturada e objetiva, considerando diversos critérios, que podem ser qualitativos ou quantitativos, a facilitação do manejo do plantio e o aumento da produtividade e rentabilidade das propriedades rurais, respeitando os pilares da sustentabilidade.
Aplicação da metodologia MASP para melhoramento do setor de Customer Success de uma empresa produtora de encontros corporativos.
Authors:   , Ferreira da Silva Erica
Published: July 2023

Em um mercado em que a competição é a palavra de ordem o cliente é quem determina as regras. A satisfação do cliente, provavelmente trará fidelização, consequentemente lucratividade para a empresa, além de novas oportunidades de mercado. Logo, se torna cada vez mais crescente a busca pelo seu sucesso. Contudo, assim como para todos os setores de uma organização, com o customer success, como é conhecida a área que se preocupa com o sucesso do cliente, não é diferente, seus processos precisam ser melhorados continuadamente, pois problemas e falhas podem afetar seu desempenho e sua eficácia. Diante desse contexto, este trabalho tem como objetivo aplicar a metodologia MASP para melhoramento do setor de customer success de uma empresa produtora de encontros corporativos. Trata-se de uma pesquisa aplicada, qualitativa, quantitativa e exploratória. Sua elaboração se deu por meio de dois procedimentos técnicos: a pesquisa bibliográfica e o estudo de caso. A aplicação do MASP ocorreu de forma efetiva conforme programado. Em termos de resultados, é primordial ressaltar que ganhos positivos foram alcançados mediante a execução das ações traçadas para conter as causas levantadas que levavam ao problema identificado. Através da realização do presente trabalho foi possível observar de forma prática o quanto a metodologia MASP pode ser benéfica para uma organização, trazer melhorias e consequentemente maior eficiência e eficácia para os processos organizacionais.
Assessment of satisfaction level among university teachers of Doctor of physical therapy program on online teaching during COVID-19 pandemic: A cross-sectional survey
Authors:   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Afzal Rabia , Hassan Rida ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Zaib Sidra ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Abid Mehwish ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Ambreen Humaira ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Iqbal Muhammad Umer ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Hussain Syed Ali ,   Department of Rehabilitation Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Kiyani Mubin Mustafa ,   Shifa college of Medical Technology, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Published: July 2023

Background: The recent covid-19 pandemic has also displayed a worldwide increase in online education as a method of learning, at an exponential rate. In the wake of the COVID-19 pandemic, the education program of physical therapy abruptly moved from on-campus to remote online medium. Objective: to find out the satisfaction level of the faculty of Doctor of Physical Therapy (DPT) in twin cities of Pakistan. Methodology: A cross-sectional survey was conducted on faculty members of various universities having the Doctor of Physical Therapy program students in Islamabad and Rawalpindi, Pakistan. A total of n=120 participants between 24 to 60 years were recruited through a nonprobability purposive sampling technique. The research team used the Online Faculty Satisfaction Survey (OFSS) which has a total of 34 questions and was designed to quantify and authenticate the satisfaction of faculty regarding the students, teaching mode as well as the institutions. Questionnaires were distributed through emails and other social media applications i.e. Facebook and WhatsApp. Results: The mean age of participants was 29.4± 6.5 years with 63.3 % females & 36.7% males. The Satisfaction levels were different among the participants. A total of n=66(55%) of participants were less satisfied with the online method of teaching whereas n=42 (35%) shows a higher level of satisfaction. The remaining 10% showed various responses regarding satisfaction level i.e. average n=4 (3.3%), moderately satisfied n=4 (3.3%), neutral n=2 (1.7%), satisfied n=2 (1.7%). Conclusion: This study concluded that the faculty of Doctor of Physical Therapy (DPT) was less satisfied with online teaching methods due to the lack of face-to-face interaction and practical components of studies. Keywords: COVID-19; education; faculty satisfaction; pandemic; university teacher.
Hybrid vascular approach reduces the length of hospital stay in patients with chronically threatening limb ischemia and multilevel atherosclerotic lesions
Authors: Barat Sorin
Published: July 2023

Introduction. Chronic limb-threatening ischemia represents the advanced stage of atherosclerosis and is often associated with significant cardiovascular morbidity, resulting in high mortality rates. The hybrid approach combines surgical and endovascular techniques, allowing for optimal revascularization of multilevel lower limb atherosclerotic lesions. Additionally, the hybrid approach offers the advantages of shorter procedure times and reduced trauma compared to the classical method. It is also expected to result in a shorter length of hospital stay for patients. Therefore, the aim of this study is to analyze the relationship between the hybrid approach and the length of hospital stay compared to the classical vascular surgical approach in patients with chronic limb-threatening ischemia, multilevel atherosclerosis, and a high anesthesiologic risk. Material and methods. The study compares the total and postoperative lengths of stay between two groups: a prospective group (N = 48) of patients treated with hybrid revascularizations, and a control group (N = 50) treated with classical vascular revascularizations. The included patients in both groups had multilevel atherosclerotic lesions (including aortoiliac, femuro-popliteal, and runoff) and chronic limb-threatening ischemia (Fontaine grade III and IV). Results. The study analyzed the total and postoperative lengths of stay in both groups, including ischemia-based subgroups. The results showed that both the total and postoperative lengths of stay were significantly shorter in the hybrid approach group compared to the control group. Conclusions. In cases where hybrid revascularizations were used, the length of hospital stay for patients with chronic limb-threatening ischemia and multilevel atherosclerosis is significantly shorter compared to the classical vascular surgical method.
The joint ultrasound markers in the early diagnosis of psoriatic arthritis
Authors: Russu Eugeniu , Sirbu Adelina , Gonta Liudmila , Homitchi Marinela , Stog Valeria
Published: July 2023

Objectives. Early establishment of arthritis in PsA based on clinical data and ultrasound examination. Material and methods. The study was conducted between 2019-2023, in the rheumatology and arthrology departments of the Timofei Moşneaga Republican Clinical Hospital, or treated in outpatient. In order to meet the requirements of the study, 100 people were examined, including 70 patients with PsA. Results. In patients with PsA the most common changes were an increase in the amount of intra-articular fluid and the proliferation of the synovial membrane. In total, fluid was detected in 293 out of 3,232 joints (9.1%). Conclusions. Ultrasound is a highly informative method in detecting a wide range of morphological changes in the joints of patients with PsA. The highest index of sensitivity appeared when inflammatory fluid, cartilage changes, osteophytes and tenosynovitis were detected.
A Review of a New Advance Technique for Energy Consumption Management by Using Active Solar Still (Nano and PCM Material)
Authors: Zulfiquar Naimuddin Ansari Prakash Patel, Pallavi Agarwal,
Published: July 2023

This review aims to provide a comprehensive analysis of active solar stills, a promising technology for sustainable water purification. Active solar stills utilize external energy sources and the sun's energy to evaporate and condense water, thereby removing impurities and producing clean drinking water. However, existing reviews on active solar stills have certain limitations. This review addresses these limitations through consistent experimental setups and meta-analyses. Additionally, the review takes a holistic approach, considering not only productivity and efficiency but also practicality, maintenance requirements, and economic feasibility. The use of phase change material (PCM) in solar stills is a potential approach to entrap the heat and reduce the losses. The review provides practical guidelines and recommendations for optimizing the performance and feasibility of active solar stills. By integrating these novel aspects, this review offers valuable insights to advance the understanding, implementation, and adoption of active solar stills as a sustainable water purification solution.
Mediation Tactics for Resolving Conflicts in Trade Unions: A Quantitative Case Study of the Nigeria National Petroleum Corporation, Port Harcourt, Rivers State, Nigeria
Authors: Akpan Hannah , Akpan Imoh Ekpenyong , Olsson Imaobong
Published: July 2023

Conflict is an inherent part of labor-management relations and has significant implications for organizations. To manage and resolve conflicts effectively, various mediation tactics have been developed to minimize costs, satisfy interests, build relationships, and control resource expenditures. This research aims to explore the utilization and effectiveness of mediation tactics in resolving conflicts within the Nigeria National Petroleum Corporation's (NNPC) Research and Development Department in Port Harcourt, River State, Nigeria. The study examines the causes of organizational conflict and investigates the role of mediation in public enterprises. Data were collected using a self-made questionnaire distributed to 100 respondents in the Research and Development Department. The questionnaire employed a five-point Likert scale to measure opinions and perceptions. The research utilized a descriptive approach, and data analysis involved non-parametric statistics, such as frequency distributions and percentage values. The findings indicate that industrial conflicts frequently arise between employers and employees in the Research and Development Department. However, the study reveals that these conflicts can be effectively managed through mediation with the involvement of the workers' representative trade union. Therefore, the research highlights the importance of regular review of labor agreements and encourages effective employer-employee consultation and negotiation to reduce conflicts, promote industrial harmony, and enhance productivity. This study emphasizes the significance of mediation tactics in resolving conflicts within trade unions. It provides insights into the specific context of the NNPC's Research and Development Department and offers recommendations for organizations and stakeholders in industrial relations to foster conflict resolution, industrial harmony, and increased productivity.
Central European with a Post-Socialist Limp
Authors: Novak Marko
Published: July 2023

According to David and Grasmann, the recognised comparative law scholars, there are basically three main criteria for differentiating between legal families and their subgroups: 1. meta-legal considerations; 2. legal sources; and 3. dogmatic legal structures. Concerning the last two criteria, which could also be designated as formal elements of a country’s legal identity, Slovenia has been deeply “immersed” in the civil law of a Central European type. Even after the decline of the Habsburg Empire, what remained to apply on the territory of nowadays Slovenia as part of the then Kingdom of Yugoslavia, was to an important extent Austrian law. Moreover, even the “decadent capitalist code” such as the Allgemeines bürgerliches Gesetzbuch (ABGB) more or less survived in spite of the communist “withering away of the state and law”, and can today still be applicable to some older cases. After one thousand years of Germanic dominance, the Slovenes turned to the East in trying to build their national identity, one hundred years ago when the Empire collapsed. Although that seemed to be a necessary move towards stronger national identity, it was their first step away from the rule of law. The second step away from that was the period of communism that endured almost half a century. Nevertheless, the formal part of the Central European legal identity somehow survived in Slovene law, with certain “injuries” of course, but it is mainly the meta-legal considerations, their sociological and psychological elements in particular, that nowadays make a difference between the situations of the rule of law in the Republic of Slovenia and, for example, in the Republic of Austria, both parts of the onetime joint Empire.
Hölderlin’s Politics of the New Mythology
Authors: Delhey Matthew J.
Published: July 2023

This article reevaluates Hölderlin’s social and political thought in the 1790s. Against Georg Lukács, it argues that Hölderlin’s politics of the new mythology, while utopian, are not mystical. In the Fragment of Philosophical Letters and the Oldest System-Programme of German Idealism, Hölderlin instead articulates two fundamental claims. Socially, the new mythical collectivity must elevate (erheben) the social relations produced by bourgeois society, exalting them in aesthetic-religious form, rather than sublating (aufheben) them, modifying both their form and their content. Politically, realizing this new collectivity requires transcending the state, and so is essentially revolutionary. Hölderlin’s prosaic writings thus supplement Hyperion’s romantic critique of modernity. They take as their point of departure a sober exposition of the social relations of the market emerging in Hölderlin’s time and, from within these relations, excavate a new mythical collectivity capable of suturing the fragmentary divisions of modern life.
Critical Phenomenology and the Mythopoetics of Nature
Authors: Smyth Bryan
Published: July 2023

The idea of “critical phenomenology” is premised on the belief that there is a radically critical political impetus intrinsic to phenomenology as such. This belief is sound, but its grounds are unclear. This article clarifies the sense of critical phenomenology by showing how it is based in the methodological need for a generative apprehension of nature as the outermost horizon of experience, that this horizon is pregiven in the mythic Urdoxa of the lifeworld, and that critical phenomenology ultimately goes beyond traditional phenomenology precisely by engaging in a moment of critical mythopoetic praxis, what Hans Blumenberg termed “work on myth,” at this level. This is highly counterintuitive but fundamental to the theoretical coherence of critical phenomenology and crucial to its viability as a transformative political practice in terms of navigating the ideological landscape of the contemporary world.
Saturation, Language, and History: Marion and Gadamer on the Communicability of Excess
Authors: DeHoust Brady
Published: July 2023

The question of this article is whether the saturated phenomenon as articulated in the early work of Jean-Luc Marion may appear within language and history, or in other words how a non- or extra-horizonal event can appear within the horizons necessary for communication and communality. This problem is significant, among other reasons, because saturated aesthetic, ethical, and religious phenomena constitute important bases for communal values. The article argues that Hans-Georg Gadamer’s philosophy of language offers resources that allow us to understand how a saturated phenomenon can appear communicably and communally without sacrificing the irreducible excessiveness of its appearance. The author draws on parallels between Marion and Gadamer to argue that the poetic word and the conversation present possibilities of the saturated phenomenon occurring within language and history, and suggests the “saturated question” as a name for this mode of appearance.
Perjury, Promising, and the Ethical Life
Authors: Barbour Charles
Published: July 2023

This article aims to initiate a discussion of the concept of perjury in Derrida’s later writing by engaging with some of his 1997–99 seminars on Le parjure et le pardon and placing them in relation to a number of works he published around the same time. It shows how, on Derrida’s account, perjury is not secondary to or parasitic upon truthful expression but an inexpungeable animating condition of the truth. It draws out the ethical and legal implications of this claim and suggests that it is integral to understanding what is sometimes presented as Derrida’s “ethical turn.” Finally, in a more critical moment, it suggests taking issue with Derrida’s characterization of the ethical life as a staccato series of isolated, discrete, even incommensurable situations or encounters, and proposes to supplement his emphasis on the ethics of the other with an equally robust ethics of the self.
Neurocriptococcosis in an immunocompetent patient: a case report
Authors: Melhado Eliana Meire , Amaral Letícia Buzzo do , Thomé Leonardo Estrela , Ferro Cibele Alexandra , Martins Marcelo Freitas , Prando Natalia , Souza Alexandre Haddad de
Published: July 2023

Introduction: Cryptococcosis is an infection acquired through the lungs, the form of central nervous system involvement is neurocriptococcosis. The diagnosis is the investigation of yeasts in the cerebrospinal fluid using china ink. Treatment is amphotericin B and fluconazole. The aim is to report a case of neurocriptococcosis in an immunocompetent patient. This is a descriptive study, through the analysis of the medical record. Case report: Female, 23 years old, healthy, with severe headache for 15 days, with progressive worsening, neurological examination without changes, performed skull computed tomography (CT) scan, no changes, cerebrospinal fluid (CSF) examination showed nucleated cells 204, presence of yeast, Venereal Disease Research Laboratory (VDRL): non-reactive and culture of Cryptococcus gattii, positive China ink. Magnetic resonance imaging of the brain showed hypersignal on T2/FLAIR (T2-weighted-Fluid-Attenuated Inversion Recovery) affecting cortical sulci, encephalic fissures, cerebellar foliae and pial surface of the brainstem and diffuse leptomeningeal impregnation, volumetric reduction of the supratentorial ventricular system, suggestive of cerebrospinal fluid hypotension, findings of leptomeningitis, related to cryptococcosis. Treatment with amphotericin B and fluconazole was initiated. Patient with onset of focal neurological deficits, amaurosis and dysarthria. She presented with refractory headache, requiring serial liquoric punctures for relief of intracranial hypertension. She evolved with instability and underwent a right ventriculoperitoneal shunt. Postoperatively, he presented left hemiparesis. Skull CT showed hematoma and emphysema of adjacent extracranial soft tissues; right frontoparietal brain lesion and edema of adjacent parenchyma. She evolved with clinical instability and died after 61 days of hospitalization. Conclusion: A pattern of CSF hypotension was shown due to compression of the frontal horns of the lateral ventricles by the granulomas. There was a need for ventriculoperitoneal shunt, but patient had fatal complications.
Hypopituitarism versus spontaneous subarachnoid hemorrhage
Authors: Rodrigues Amanda Gabriele Coelho , Estrela Ana Cassia Gonzalez dos Santos , Tavares Ligia Aurelio Vieira Pianta , Silva Beatriz Trajano Costa da
Published: July 2023

Introduction: Spontaneous subarachnoid hemorrhage (SAH) is a medical emergency characterized by bleeding in the subarachnoid space, of nontraumatic etiology. Studies demonstrate the relationship of HSA in the pathogenesis of hypopituitarism, which are important due to the need to develop new therapeutic and diagnostic tools. Objectives: To highlight hormonal complications after SAH. Methods: A literature review was carried out in the Scielo and PubMed databases, using the descriptors: “aneurysmal subarachnoid haemorrhage” “hormone deficiency” and “hypopituitarism”, limited to articles in English, available in full and published in the last five years. Twenty-seven articles were found, of which eight entered the study. Results: The study indicates that hypopituitarism after SAH is associated with an unfavorable neurological outcome. Pointing to changes in gonadotropins in men, with less hair on the face and body, gynecomastia and hypogonadism. Anemia due to decreased erythropoiesis associated with hypogonadism, growth hormone deficiency associated with decreased exercise tolerance, increased centripetal fat, and premature atherosclerosis. Hyperprolactinemia is common in this group of patients due to interference with dopaminergic inhibition. These hormonal dysfunctions trigger fatigue, headache, mood swings, depression, cognitive impairment and inability to perform daily activities in these patients, often being confused with neurological sequelae resulting from the patient’s cerebral hemorrhage. Conclusion: The endocrinological control of patients with SAH is relevant, due to its uncertain immediate prognosis. Hypopituitarism is a relevant complication, which if identified early on, there is the possibility of hormone replacement and improvements in the patient’s quality of life. Knowledge about the complications of SAH has the role of clarifying not only hypopituitarism, but also cognitive diseases, contributing to elucidate possible therapeutic targets, gaps to be investigated on the subject.
Huntington’s disease mortality in Brazil from 2011 to 2020: an epidemiological study
Authors: Melo Leonardo José Rodrigues de Araújo , Rodrigues Pedro Vitor Ferreira , Pinheiro Amanda Pereira Sindeaux , Radtke Lucas Soares , Barreto Francisco Luciano Honório
Published: July 2023

Introduction: Huntington’s Disease (HD) is a dominant genetic neurodegenerative pathology, with full penetrance, characterized by the CAG expansion of the huntingtin gene on chromosome 4, leading to neuronal death due to protein accumulation, which generates clinical presentation of motor, cognitive and psychiatric symptoms, especially Huntington’s chorea. Objectives: To describe the epidemiological profile of mortality from HD in Brazil between the years 2011 to 2020. Methods: This work is an epidemiological investigation study of HD mortality between the years 2011 to 2020. Data were collected from the Mortality Information System of DATASUS. Data were organized and analyzed using the Jamovi® statistical software. Results: 1,049 deaths from HD were confirmed in the analyzed period. Regarding the temporal analysis of deaths from HD, an average of 105 (±33.1) annual cases. There was a predominance of deaths in the Southeast compared to other regions of the country, concentrating 505 (41% of the total). Among deaths from HD, there was a higher prevalence of female deaths, with 583 deaths (55.5% of total). Regarding age, there was a predominance of deaths in the age group from 50 to 59 years old, totaling 311 (29.6% of the total). In regards to education, the deaths of individuals with 8 to 11 years of schooling were more prevalent, totaling 251 (23.9% of the total). In respect of skin color, white individuals accounted for the largest share of deaths, accounting 735 (70.0% of the total). Conclusion: The results found an annual average of deaths increasing and dispersed, which may reflect a greater sensitivity of diagnostic methods, requiring further studies to confirm this association. Regarding the epidemiological profile, there was a higher prevalence in women, from the Southeast, aged over 50 years and with more years of education.
Sözleşmeli Tarım Modelinin Gıda İmalat Sanayinde İhracat Açısından Değerlendirilmesi
Authors: DURU Sinan , HAYRAN Seyit , GÜL Aykut
Published: July 2023

Orta (ılıman) kuşakta bulunan Türkiye verimli toprakları ve uygun iklim koşulları nedeniyle tarımsal ürün çeşitliliğinde önemli bir potansiyele sahiptir. Bu tarımsal potansiyelin yanı sıra gıda sanayinde mevcut kurulu kapasitesinin yüksek olmasına karşın kalite açısından uygun ve yeterli tarımsal hammaddenin temininde sıkıntılar yaşanmaktadır. Bu durum kurulu kapasitesinin yetersiz kullanımına ve hammaddenin yurt dışından ithalat yoluyla temin edilmesine neden olmaktadır. Gıda imalat sanayinde bu koşullar işletmeleri hammadde temininde farklı arayışlara itmiş olup, bu arayışlardan en göze çarpan örneklerden birisi sözleşmeli tarım modeli olmuştur. Araştırmada ilk olarak Dünyada ve Türkiye’de sözleşmeli tarım üzerine yapılan araştırmalar incelenerek konuyla ilgili bilgi verilmeye çalışılmıştır. Araştırmanın amacına uygun olarak, gıda ve içecek sanayinde sözleşmeli tarımın ihracatta uygulanabilirliği, dünyada uygulamaları, konuyla ilgili yapılan mevzuat düzenlemeleri üzerinde durulmuş ve bu potansiyelin artırılmasına yönelik çözüm önerileri sunulmaya çalışılmıştır. Sonuç olarak, Türkiye’de sözleşmeli tarım uygulamaları dünyaya göre yeni olmasına karşın, özellikle gıda imalat sanayinde uygulama alanlarının zaman içinde arttığı ve atıl kapasitenin kullanılmaya çalışıldığı gözlenmiştir.
Bazı Aspir (Carthamus Tinctorius L.) Çeşitlerinde Farklı Tuz Konsantrasyonlarının Çimlenme ve Çıkış Üzerine Etkisi
Authors: ÇAVUMİRZA Murat , DEMİR İsmail
Published: July 2023

Bu çalışmada, önemli yağ bitkilerinden biri olan aspir (Carthamus tinctorius L.) çeşitlerinin çimlenme ve çıkış dönemlerinde tuz (NaCl) stresine karşı tepkilerini belirlemek amacıyla 2022 yılında Ahi Evran Üniversitesi laboratuvarında yürütülmüştür. Denemelerde Linas, Olas, Balcı çeşitleri materyal olarak kullanılmıştır. Araştırmada aspir tohumlarına çimlenme ve çıkış döneminde tuz stresini belirlemek için saf su (kontrol) ile 4 farklı tuz (50 mMol, 100 mMol, 150 mMol ve 200 mMol) konsantrasyonları uygulanmıştır. Deneme, tesadüf parselleri faktöriyel deneme desenine göre 4 tekerrürlü olarak laboratuvar koşullarında petri kaplarında yürütülmüştür. Çimlenme oranı (%), gövde uzunluğu (cm), kök uzunluğu (cm), yaş gövde ağırlığı (mg), yaş kök ağırlığı (mg), kuru gövde ağırlığı (mg) ve kuru kök ağırlığı (mg) incelenmiştir. Araştırmada elde edilen bulgulara göre; farklı tuz konsantrasyonlarında aspir çeşitlerinin çıkış oranı %54-96.50, gövde uzunluğu 2.775-8.383 cm, kök uzunluğu 0.55-5.817 cm, yaş gövde ağırlığı 122.72-315.67 mg, yaş kök ağırlığı 13.01-67.66 mg, kuru gövde ağırlığı 14.30-23.52 mg ve kuru kök ağırlığı 1.15-3.55 mg aralığında değişim gösterdiği tespit edilmiştir. Denemenin sonucunda; tuz oranlarının artmasıyla birlikte çıkış oranı (%), gövde uzunluğu (cm), kök uzunluğu (cm), yaş gövde ağırlığı (g) ve yaş kök ağırlığı (g) değerlerinde düşüş tespit edilmiştir. Ayrıca tuz konsantrasyonu artışında incelenen özellikler bakımından Linas çeşidinin daha iyi performans gösterdiği gözlenmiştir. Araştırmada elde edilen bulgulara göre; farklı tuz konsantrasyonlarında aspir çeşitlerinin çıkış oranı %54-96.50, gövde uzunluğu 2.775-8.383 mm, kök uzunluğu 0.55-5.817 mm, yaş gövde ağırlığı 122.72-315.67 mg, yaş kök ağırlığı 13.01-67.66 mg, kuru gövde ağırlığı 14.30-23.52 mg ve kuru kök ağırlığı 1.15-3.55 mg aralığında değişim gösterdiği tespit edilmiştir.

Denemenin sonucunda; tuz oranlarının artmasıyla birlikte çıkış oranı (%), gövde uzunluğu (mm), kök uzunluğu (mm), yaş gövde ağırlığı (g) ve yaş kök ağırlığı (g) değerlerinde düşüş tespit edilmiştir. Ayrıca tuz konsantrasyonu artışında incelenen özellikler bakımından Linas çeşidinin daha iyi performans gösterdiği gözlenmiştir.
Domates Yetiştiriciliğinde Tuz Stresinin Olumsuz Etkilerine Karşı Kitosan Uygulaması
Authors: BULUT Hüseyin , ÖZTÜRK Halil İbrahim
Published: July 2023

Küresel düzeyde meydana gelen iklim değişiklikleri, savaşlar, nüfus artışı, tarım arazilerindeki azalma gibi nedenlere toprak tuzluluğu da eklenince üretim verimliliği giderek önem kazanmıştır. Tuzluluk bitki gelişmesini önemli derecede etkilemektedir. Bundan dolayı bu konuda çalışmalar yoğunlaşmıştır. Bitki gelişimini tuz stresinden korumak için organik çözümlere odaklanılmıştır. Bu çalışmada domates fidelerinde tuz stresini hafifletmek için kitosan biyopolimeri uygulanmıştır. Tuz stresine karşı bitki savunma refleksleri Süperoksit Dismutaz (SOD), Katalaz (CAT) ve Malondialdehit (MDA) enzim seviyelerindeki değişim ile incelenmiştir. Tuz stresi için uygulanan kitosanın anlamlı derecede SOD, CAT ve MDA enzim seviyelerini etkilediği tespit edilmiştir. Kitosanın abiyotik streslerden korunmak için kullanışlı ve makul bir araç olduğu ifade edilebilir. Ayrıca enzim değerlerinin bitkilerde strese neden olan etkenlerin tespitinde ve bitkisel yanıt mekanizmalarının aydınlatılmasında kullanışlı olduğu belirlenmiştir.
Governos Petistas e Proteção Social no Capitalismo
Authors: Amorim Costa Victor Cesar
Published: July 2023

Houve expansão do caráter privado e residual da proteção social nos governos petistas (2003-2016). Esta pesquisa buscou apreender como as produções marxistas descreveram e explicaram essas transformações. Foi realizada uma revisão bibliográfica híbrida, inspirada tanto em elementos da revisão sistemática quanto da revisão narrativa, restrita a produções de origem acadêmica e publicadas em formato de livro. Foram selecionadas oito obras após fases consecutivas de filtragem dos resultados de buscas. A revisão indica consenso em torno do aprofundamento do ordenamento da proteção social a partir da lógica do mercado e da proteção pública residual. Todavia, as políticas de corte neoliberal aplicadas tomaram inéditas proporções e efeitos em termos da história recente do país e de sua abissal desigualdade. O boom das commodities e os efeitos de seu declínio somados aos rebatimentos "iniciais" e "tardios" da crise de 2008 possibilitaram um raio maior de manobra aos governos petistas. Por fim, foi constatada a ocorrência de dois golpes contra a proteção social (2014-2016), quando boa parte dos ganhos sociais foi sacrificada.
Temperature-Properties Relationships of Martensitic Stainless Steel for Improved Utilization in Surgical Tools
Authors: Ahmed Ibrar , Badar-ud-Din Soomro  , Muhammad Irfan  , Noor Faraz Khan  , Muhammad Bilal Afzal  , Junaid Israr  , Ambreen Saddozai  , Muhammad Yousif
Published: July 2023

Sintering temperature and environment plays a very important role in strengthening powder particles of compacting surgical parts by cold powder metallurgy technique. Powder metallurgy is a process of producing components/tools by compacting finely metallic or nonmetallic powders. Generally, in the last decade, these tools were produced by conventional casting techniques but now first time in Pakistan this technique is introduced to develop surgical tools/parts. In this study, the effect of sintering behavior by varying temperatures and environments was studied. The AISI 420 Stainless steel compacted surgical parts (Scalpel and scissor) were sintered at 1000 °C to 1300 °C for 30 minutes in a vacuum and an inert environment in the presence of Argon. The compact density, microstructure and mechanical properties were studied. Microstructural characteristics like porosity, and crystalline size were studied by optical microscope. The hardness values and density of the final parts were also measured through the Rockwell hardness machine and by the Archimedes principle. Decreasing the porosity in the final parts will increase the mechanical properties of sintered parts. Adopting the present process for the development of surgical tools after further refining, the process will prove beneficial in the cost-effectiveness, time and energy saving of the present product.
Involving Problem-Based Learning as an Alternative for EFL Students’ Writing Improvement: A Method for Teaching Writing
Authors: Setlight Kharisma C. M. S. , Betaubun Martha , Kartika Vicha
Published: July 2023

In fact, writing is one of the language skills that is emphasized in learning English in Curriculum 2013. As one of the language skills, writing skills need to be improved because it is a productive and expressive language skill that is needed to fulfill daily communication needs. Seeing the crucial role of writing, this present study intent to examine the problem based learning as an alternative model for EFL students’ writing improvement. Classroom action research with two cycles was implemented to study this phenomena. Moreover, this study involved 18 students of class XI SMA YPPK YOS SUDARSO Merauke, in collecting the data, this study used observation sheet for both teacher and students’ activities, meanwhile to see students’ writing improvement, explanation text writing was applied in both cycles. As the result, Problem based learning could improve students’ writing, it could be seen in each cycles’ scores, where cycle I writing was 63.33% and improved in cycle II 81%. In cycle I, most of students did not pass the minimum completeness which was 75, meanwhile in cycle II most of students passed. The improvement based on the observation results in both cycles are also being the success category in this study, in cycle I both teacher and students obtained 67.85% (good category) and 57.14% (enough category), improved in cycle II which was 87.5 (excellent category) and 83.92% (excellent category).
O solipsismo prático e o pecado original na Religião nos Limites da Simples Razão
Authors: Conceição Jorge , Perez Daniel Omar
Published: July 2023

O objetivo do presente artigo é evidenciar as bases de um solipsismo moral na filosofia prática kantiana. Na Crítica da razão prática, Kant define o solipsismo moral como um sistema de satisfação das inclinações, cuja finalidade é a felicidade própria. Em razão disso, é necessário demonstrar de que forma uma ação egoísta pode ser classificada como livre e de que maneira acontece a anulação do efeito do sentimento de respeito à lei na disposição de ânimo do ser humano. Para isso, analisaremos, inicialmente, o conceito de pecado original em Kant como o desejo de não se abster daquilo que a lei moral proíbe. Em seguida, examinaremos a forma do imperativo egoísta na razão prática, pois o ser racional finito se reconhece como o fim último da sua vontade, ou seja, como o único ser livre. E, por fim, indicaremos que o autoengano é uma forma de anulação do efeito do sentimento moral na receptividade da lei moral pelo ser humano.
The detection of ascorbic acid in orange (Rutaceae Sp.) using titration technique
Authors: Sufitri Erlyn , Emelda Emelda , Munir Muhammad Abdurrahman , Aprilia Veriani
Published: July 2023

Vitamin C is a vitamin that belongs to the group of water-soluble vitamins. Some sources of vitamin C are obtained from fresh vegetables and fruits. Vitamin C has several functions in the body, including helping to replenish the body's supply of twins and optimizing functionality. This study aims to determine the levels of vitamin C in lime, kaffir lime, tangerine, and lemon by the iodometric titration method. The sample used in this study was obtained from the Brosot market, Kec. Galur, Kab. Kulon Progo, Yogyakarta. The vitamin C levels obtained from lime, kaffir lime, tangerine, and lemon were 0.004%, 0.004%, 0.002%, and 0.005%.
The determination of vitamin C in guava (Myrtaceae species) using spectrophotometric approach
Authors: Aliansa Tania , Munir Muhammad Abdurrahman , Aprilia Veriani , Emelda Emelda
Published: July 2023

Vitamin C is one of the essential vitamins for body health. However, vitamin C cannot be produced by the body itself. Thus, to fulfill the vitamin C requirement, it can be obtained by consuming fruits and vegetables. The purpose of this study was to find out and analyze the levels of vitamin C in guava (Psidium guajava L.), crystal guava (Psidium guajava (L.) Merr.), and water guava (Syzygium aquenum). This study used UV-Vis spectrophotometry to analyze the vitamin C content. The results of vitamin C levels in samples such as red guava, crystal guava, and water guava were 21.16 mg/5 g ± 0.005, 20.79 mg/5 g ± 0.029, and 19.16 mg/5 g ± 0.089, respectively. Based on these outcomes, it can be concluded that high levels of vitamin C can be acquired in red guava (Psidium guajava L.)
cambio en la tutoría virtual para los paradigmas emergentes
Authors: Sandoval-Valero Erika María , Ruiz-Cañadulce Edith Marcela , Pardo-Santamaría Diego Fernando
Published: July 2023

El presente documento describe parte del trabajo desarrollado en el proyecto “Percepción de los módulos e-learning de la Universidad de Boyacá por parte de los estudiantes”, el cual tiene como objetivo” Evaluar la percepción de los estudiantes frente a los módulos e-learning de la Universidad de Boyacá”.  Este escrito, es un fragmento de la ejecución de uno de los objetivos específicos del mismo, en donde se observó la necesidad de dotar a los docentes de recursos, herramientas y estrategias para mejorar la tutoría virtual y así impactar en la percepción que se tiene de las asignaturas virtuales.  Dentro de los resultados obtenidos se resalta el desarrollo de un curso virtual donde se plasmó de manera objetiva el papel del tutor virtual como mediador en los procesos de aprendizaje basados en el modelo pedagógico institucional el cual se fundamenta en la complejidad, de igual manera se obtuvo un instructivo el cual contiene aspectos relevantes para una adecuada tutoría en la metodología E-learning.
Calidad de vida de padres de hijos con enfermedades oncológicas
Authors: Almeida Maldonado Jenny Angélica , Abril Lucero Gabriela Lorena , Rubio Andrade Jhosselin Nicole , García Ramos Diana Carolina
Published: July 2023

El cáncer es una enfermedad a nivel mundial que influye negativamente en la vida de los pacientes y su familia, en la mayoría de los casos la preocupación y el cuidado es para el paciente, el objetivo de esta investigación es comprender las vivencias sobre la calidad de vida que construyen los padres de familia con hijos con enfermedades oncológicas. Se utilizó la metodología cualitativa con la respectiva unidad de análisis de las vivencias de los padres, desde el estudio fenomenológico basado en la recolección de datos a través de la entrevista semiestructurada a 8 padres externos e internos del hospital oncológico, resaltando la recopilación de datos desde la codificación axial. Los resultados indican que hay factores que influyen en la calidad de vida de los padres desde las vivencias que han dejado emociones positivas y desesperanzadoras frente a las responsabilidades de la enfermedad de sus hijos, familia, salud física, economía, prioridades personales y apoyo psicológico. En el estudio se evidencio que los padres de familia de hijos con cáncer dieron cambios en su vida a nivel personal y familiar, además enfatizaron en la necesidad de ser acompañados en la contención emocional para ayudar a llevar la enfermedad a su hijo.
Motivation and Beyond?
Authors: Schierbaum Sonja
Published: July 2023

The aim of this paper is to show that, unlike proponents of Humean accounts of intentional action, Ockham can also answer the fundamental question of why we desire anything at all. For Ockham, desire cannot be the starting point of the explanation, since desire presupposes yet another kind of appetitive act that is objectual, or non-propositional, in its nature. Ockham calls this love (amor). It should become clear that Ockham's approach, even in his day, is not common. It is, however, worthy of detailed examination because it furthers a deeper and more complete understanding of intentional action by shedding light on this more fundamental question. In his terminology, love is the most basic kind of unconditional willing, not least because it is purely objectual: we appreciate persons as ends, not as means. The explanation of intentional action has to start somewhere. And, for Ockham, it starts with love for persons.