bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Regioselective Oxo‐Amination of Alkenes and Enol Ethers with N‐Bromosuccinimide—Dimethyl Sulfoxide Combination: A Facile Synthesis of α‐Amino‐Ketones and Esters.
Authors: Prasad Pragati K. , Reddi Rambabu N. , Sudalai Arumugam
Published: June 2016

An oxo‐amination of alkenes and enol ethers to afford α‐imido carbonyl compounds is developed.
ChemInform Abstract: CuI‐Catalyzed Oxidative Cross Coupling of Oximes with Tetrahydrofuran: A Direct Access to O‐Tetrahydrofuran‐2‐yl Oxime Ethers
Authors: Ren Zhi‐Hui , Zhao Mi‐Na , Guan Zheng‐Hui
Published: June 2016

starting from ketoximes and aldoximes
ChemInform Abstract: Metal‐Free Chemoselective Oxidative Dehomologation or Direct Oxidation of Alcohols: Implication for Biomass Conversion.
Authors: Kim Sun Min , Shin Hun Yi , Kim Dong Wan , Yang Jung Woon
Published: June 2016

A method for transition‐metal‐free and chemoselective oxidation of alcohols [(I) and (III)] for oxidative dehomologation or direct oxidation by appropriately switching the solvent polarity is developed.
ChemInform Abstract: Enantioselective Reduction of Ethyl 3‐Oxo‐5‐phenylpentanoate with Whole‐Cell Biocatalysts.
Authors: Zadlo Anna , Schrittwieser Joerg H. , Koszelewski Dominik , Kroutil Wolfgang , Ostaszewski Ryszard
Published: June 2016

Screening of a collection of microorganisms leads to the discovery of stereocomplementary biocatalysts suitable for accessing both enantiomers of ethyl 3‐hydroxy‐5‐phenylpentanoate (II) in a preparative scale.
ChemInform Abstract: Pd/C‐Catalyzed Aminocarbonylation of Aryl Iodides via Oxidative C—N Bond Activation of Tertiary Amines to Tertiary Amides.
Authors: Mane Rajendra S. , Bhanage Bhalchandra M.
Published: June 2016

A novel oxidative Pd‐catalyzed aminocarbonylation of aryl iodides with CO and tertiary amines to give benzamides (IV) in good yields is presented.
ChemInform Abstract: Iron‐Catalyzed Oxidative Sulfonylation of Enol Acetates: An Environmentally Benign Approach to β‐Keto Sulfones.
Authors: Yadav Vinod K. , Srivastava Vishnu P. , Yadav Lal Dhar S.
Published: June 2016

This is the first example of an iron‐catalyzed sulfonylation of aryl enol acetates with sulfonyl hydrazides to yield β‐keto sulfones.
ChemInform Abstract: Synthesis of Symmetrical Terphenyl Derivatives by PdCl2‐Catalyzed Suzuki—Miyaura Reaction of Dibromobenzene Using 3‐(Diphenylphosphino)propanoic Acid as a Ligand.
Authors: Gu Ningning , Liu Yashuai , Liu Ping , Ma Xiaowei , Liu Yan
Published: June 2016

A simple and efficient catalytic system consisting of 3‐(diphenylphosphino) propanoic acid PdCl2 catalyzes the title reaction to obtain the desired terphenyl products, in good to excellent yields.
ChemInform Abstract: Ligand‐Accelerated Stereoretentive Suzuki—Miyaura Coupling of Unprotected 3,3′‐Dibromo‐BINOL.
Authors: Qu Bo , et al.
Published: June 2016

Enantiomerically pure bis‐arylated BINOL derivatives are prepared with complete retention of enantiopurity by palladium‐catalyzed Suzuki—Miyaura coupling of unprotected dibromo‐BINOL with various arylboronic acids.
ChemInform Abstract: Gram Scale Conversion of R‐BINAM to R‐NOBIN.
Authors: Patel Darshan C. , Breitbach Zachary S. , Woods Ross M. , Lim Yeeun , Wang Andy , Foss Frank W. Jr. , Armstrong Daniel W.
Published: June 2016

An efficient single‐step conversion of (R)‐BINAM to highly enantiopure (R)‐NOBIN is developed.
ChemInform Abstract: Synthesis and Photophysical Properties of 9,10‐Bis(3‐aryl‐2‐naphthyl)anthracenes.
Authors: Umeda Rui , Kimura Masahiro , Tobe Yoshito , Nishiyama Yutaka
Published: June 2016

Title compounds (III) are prepared by benzannulation reaction of 9,10‐bis(arylethynyl)anthracene derivatives (I) and 2‐(phenylethynyl)benzaldehyde (II) in the presence of Cu or Re catalyst, resp., and trichloroacetic acid.
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of 1,6‐Enynes with Cyclopropylideneacetamides.
Authors: Yoshizaki Soichi , Nakamura Yu , Masutomi Koji , Yoshida Tomoka , Noguchi Keiichi , Shibata Yu , Tanaka Ken
Published: June 2016

furnishing spirocyclohexenes in excellent enantioselectivities with retaining cyclopropane rings
ChemInform Abstract: A Simple, Convenient, Highly Regioselective Synthesis of Isobenzofuran‐1(3H)‐ones (Phthalides) as well as Maculalactone A & B, the Bioactive Butyrolactones.
Authors: Joardar Soumen , Chakravorty Santanu , Das Sakti P.
Published: June 2016

The title furanones are conveniently prepared from various phthalate esters.
ChemInform Abstract: Copper‐Catalyzed Oxidative [2 + 2 + 1] Annulation of 1,n‐Enynes with α‐Carbonyl Alkyl Bromides Through C—Br/C—H Functionalization.
Authors: Hu Ming , Song Ren‐Jie , Ouyang Xuan‐Hui , Tan Fang‐Lin , Wei Wen‐Ting , Li Jin‐Heng
Published: June 2016

The Ag(I)‐promoted oxidative [2 + 2 + 1]‐annulation of enynes with activated alkyl bromides is achieved in the presence of Cu‐catalyst to form three new C—C bonds and two rings in a single step.
ChemInform Abstract: Gold(I)‐Catalyzed Cyclization/Nucleophilic Substitution of 1‐(N‐Sulfonylazetidin‐2‐yl) Ynones into N‐Sulfonylpyrrolin‐4‐ones.
Authors: Miaskiewicz Solene , Weibel Jean‐Marc , Pale Patrick , Blanc Aurelien
Published: June 2016

A series of N‐tosylpyrrolin‐4‐ones is readily obtained by gold‐catalyzed reaction of 1‐(N‐tosylazetidin‐2‐yl)ynones (I) with alcohols.
ChemInform Abstract: Indolylindolinone: Easily Accessible, Tunable, and Wide‐Range Absorbing Dyes.
Authors: Shigeno Ami , Matsuno Takashi , Hiroto Satoru , Shinokubo Hiroshi
Published: June 2016

Dehydrative coupling between indoles and isatins provides indolylindolinones as novel dyes with wide‐range absorption due to intramolecular charge‐transfer interactions.
ChemInform Abstract: Palladium‐Catalyzed Alkylarylation of Acrylamides with Unactivated Alkyl Halides.
Authors: Wang Hua , Guo Li‐Na , Duan Xin‐Hua
Published: June 2016

A wide range of functionalized oxindoles is prepared from alkyl‐, perfluoroalkyl‐, and benzyl halides.
ChemInform Abstract: Iron‐Catalyzed Decarboxylative [4 + 1] Cycloadditions: Exploiting the Reactivity of Ambident Iron‐Stabilized Intermediates.
Authors: Wang Qiang , Qi Xiaotian , Lu Liang‐Qiu , Li Tian‐Ren , Yuan Zhi‐Guang , Zhang Kai , Li Bin‐Jie , Lan Yu , Xiao Wen‐Jing
Published: June 2016

Iron‐catalyzed decarboxylative [4 + 1] cycloaddition reactions are described for the first time.
ChemInform Abstract: A One‐Pot, Multicomponent Synthesis of 5′‐Amino‐2,2′‐dioxospiro[indoline‐3,3′‐pyrrole]‐4′‐carbonitriles.
Authors: Adib Mehdi , Yasaei Zahra , Mirzaei Peiman
Published: June 2016

In this novel approach, the title compounds are prepared from isatins (I) and (V), malonodinitrile (II) and isocyanides (III).
ChemInform Abstract: Tuning the Basicity of a Metal‐Templated Broensted Base to Facilitate the Enantioselective Sulfa‐Michael Addition of Aliphatic Thiols to α,β‐Unsaturated N‐Acylpyrazoles.
Authors: Ding Xiaobing , Tian Cheng , Hu Ying , Gong Lei , Meggers Eric
Published: June 2016

Good to excellent yields and enantioselectivities are achieved at very low catalyst loadings of 0.2‐2.5 mol%.
ChemInform Abstract: Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives.
Authors: Albertshofer Klaus , Mani Neelakandha S.
Published: June 2016

Lithium tetramethylpiperidide is found to efficiently promote the regioselective fluorination of N‐protected 2‐substituted imidazoles (I) and (IV) to give the products regioselectively.
ChemInform Abstract: Palladium(0)‐Mediated Cyclization‐Coupling of β,γ‐Unsaturated Oximes and Aryl Iodides.
Authors: Mikesell Joshua , Mosher Michael D.
Published: June 2016

The tandem Pd(0)‐mediated nucleometalation ‐ cross coupling of unsaturated oximes (I) and aryl iodides (II) is shown to provide 3,5‐disubstituted 2‐isoxazolines (III) in varying yields.
ChemInform Abstract: Synthesis of 2‐Amino‐substituted‐1,3,4‐thiadiazoles via 2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) Mediated Intramolecular C—S Bond Formation in Thiosemicarbazones.
Authors: Singh Sarangthem Joychandra , Rajamanickam Suresh , Gogoi Anupal , Patel Bhisma K.
Published: June 2016

An intramolecular cyclization of thiosemicarbazones (I) using DDQ is developed to afford a series of 2‐amino‐substituted‐1,3,4‐thiadiazoles (II) in moderate to good yields.
ChemInform Abstract: Synthesis of Isocoumarins via Silver(I)‐Mediated Annulation of Enol Esters.
Authors: Panda Niranjan , Mishra Priyadarshini , Mattan Irshad
Published: June 2016

DMAP and AgOAc are used as mild promoters for the cyclization of enol esters (I) to 4‐carbonyl substituted coumarins.
ChemInform Abstract: Sequential Mukaiyama—Michael Reaction Induced by Carbon Acids.
Authors: Yanai Hikaru , Kobayashi Osamu , Takada Kenji , Isono Takuya , Satoh Toshifumi , Matsumoto Takashi
Published: June 2016

A strong C—H acidic compound (TCA) is described as catalyst for the sequential Mukaiyama—Michael aldol reaction of α‐pyrone derivatives with the silyl ketene acetal (II) and ketones or different α,β‐unsaturated ketones.
ChemInform Abstract: Substrate‐Controlled, One‐Pot Synthesis: Access to Chiral Chroman‐2‐one and Polycyclic Derivatives.
Authors: Sun Xue‐Li , Chen Ying‐Han , Zhu Dan‐Yang , Zhang Yan , Liu Yan‐Kai
Published: June 2016

The asymmetric reductive reaction of 2‐hydroxycinnamaldehydes (I) with aroylacrylic esters (II) leads to intermediate chroman‐2‐ols, which are oxidized with PCC to chroman‐2‐ones (III) or cyclized with TosOH to tricyclic γ‐lactones (IV).
ChemInform Abstract: Sequential Multicomponent Synthesis of Highly Functionalized Pyridin‐2(1H)‐one Derivatives.
Authors: Seixas Raquel S. G. R. , Ribeiro Gustavo C. , Guieu Samuel , Silva Artur M. S.
Published: June 2016

A three‐component reaction of 2‐formyl‐chromenes (I) with Meldrum′s acid and primary amines affords pyridin‐2(1H)‐ones (IV) or the corresponding non‐decarboxylated products (V) depending on the reaction conditions.
ChemInform Abstract: Copper‐Catalyzed Regioselective C—H Sulfonylation of 8‐Aminoquinolines
Authors: Wei Jun , Jiang Jingxing , Xiao Xinsheng , Lin Dongen , Deng Yuanfu , Ke Zhuofeng , Jiang Huanfeng , Zeng Wei
Published: June 2016

via bidentate‐chelation assistance
ChemInform Abstract: Metal‐Free Radical Haloazidation of Benzene‐Tethered 1,7‐Enynes Leading to Polyfunctionalized 3,4‐Dihydroquinolin‐2(1H)‐ones.
Authors: Wang Ai‐Fang , Zhu Yi‐Long , Wang Shu‐Liang , Hao Wen‐Juan , Li Guigen , Tu Shu‐Jiang , Jiang Bo
Published: June 2016

A novel uncatalyzed three‐component cascade haloazidation of enynes of type (I), (III), and (V) with NXS and TmsN3 is described to give dihydroquinolinone derivatives by using PIDA as oxidant.
ChemInform Abstract: Modular Copper‐Catalyzed Synthesis of Chromeno[4,3‐b]quinolines with the Utilization of Diaryliodonium Salts.
Authors: Aradi Klara , Bombicz Petra , Novak Zoltan
Published: June 2016

The title chromenoquinolines are prepared by a novel copper‐catalyzed oxidative ring closure ‐arylation concept utilizing arylpropynyloxy‐benzonitriles and diaryliodinium salts.
ChemInform Abstract: Synthesis of Pyrido‐Fused Quinazolinone Derivatives via Copper‐Catalyzed Domino Reaction.
Authors: Liu Meilin , Shu Miaomiao , Yao Chaochao , Yin Guodong , Wang Dunjia , Huang Jinkun
Published: June 2016

The copper‐catalyzed reaction of isatins (I) with 2‐bromopyridines (II) leads to a variety of pyrido‐fused quinazolinones (III).
ChemInform Abstract: Ruthenium‐Catalyzed C—C Bond Cleavage of 2H‐Azirines: A Formal [3 + 2 + 2] Cycloaddition to Fused Azepine Skeletons.
Authors: Li Tengfei , Xu Fen , Li Xincheng , Wang Chunxiang , Wan Boshun
Published: June 2016

The presented approach features an unprecedented ruthenium‐catalyzed C—C bond cleavage of 2H‐azirines at room temperature which allows access to N‐containing seven‐membered rings via reactions with diynes.
ChemInform Abstract: Transition‐Metal‐Free Regioselective Synthesis of Alkylboronates from Arylacetylenes and Vinyl Arenes.
Authors: Yang Kai , Song Qiuling
Published: June 2016

Various alkylboronates are synthesized starting either from arylacetylenes or vinyl arenes by reaction with bis(pinacolato)diboron (II).
ChemInform Abstract: C(sp3)—P versus C(sp2)—P Bond Formation: Catalyst‐Controlled Highly Regioselective Tandem Reaction of Ene‐Yne‐Ketones with H‐Phosphonates.
Authors: Yu Yue , Yi Songjian , Zhu Chuanle , Hu Weigao , Gao Bingjie , Chen Yang , Wu Wanqing , Jiang Huanfeng
Published: June 2016

Various phosphorylated furans are prepared regioselectively via a Cu‐catalyzed C(sp3)—P or base‐promoted C(sp2)—P bond formation, involving 5‐exo‐dig cyclization, carbene migration insertion, and Michael addition.
ChemInform Abstract: A Chemoenzymatic Route to Prepare Acyclic Nucleoside Analogues
Authors: Palazzolo Martin A. , Nigro Mariano J. , Iribarren Adolfo M. , Lewkowicz Elizabeth Sandra
Published: June 2016

involving an aldol condensation of aldehydes of various nucleobases catalyzed by a dihydroxyacetone phosphate‐dependent aldolase (rabbit muscle aldolase)
ChemInform Abstract: Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents.
Authors: Sahu Pramod K. , Kim Gyudong , Nayak Akshata , Ahn Ji Yoon , Ha Min Woo , Park Cheonhyoung , Yu Jinha , Park Hyeung‐geun , Jeong Lak Shin
Published: June 2016

The synthesis of the selena‐analogue (III) of known antiviral agent Adefovir (IV) is described.
ChemInform Abstract: Furanolabdanoid‐Based 1,2,4‐Oxadiazoles: Synthesis and Cytotoxic Activity.
Authors: Mironov Maxim E. , Pokrovsky Mikhail A. , Kharitonov Yurii V. , Shakirov Makhmut M. , Pokrovsky Andrey G. , Shults Elvira E.
Published: June 2016

Several 15,16‐epoxy‐8,13,14‐labdatriene derivatives are obtained via multistep synthesis from formyl derivatives of the diterpenoid lambertianic acid.
ChemInform Abstract: New Antibacterial Isocoumarin Glycosides from a Wetland Soil Derived Fungal Strain Metarhizium anisopliae.
Authors: Tian Jie‐Feng , Li Peng‐Ju , Li Xiao‐Xia , Sun Ping‐Hua , Gao Hao , Liu Xing‐Zhong , Huang Peng , Tang Jin‐Shan , Yao Xin‐Sheng
Published: June 2016

Eight new isocoumarin glycosides (Ia‐d), (II), (III), (IVa), and (IVb) are isolated from the wetland soil‐derived fungal strain Metarhizium anisopliae.
ChemInform Abstract: Peganumine B‐I and Two Enantiomers: New Alkaloids from the Seeds of Peganum harmala Linn. and Their Potential Cytotoxicity and Cholinesterase Inhibitory Activities.
Authors: Yang Ya‐di , Cheng Xue‐mei , Liu Wei , Han Zhu‐zhen , Chou Gui‐xin , Wang Ying , Sun Du‐xin , Wang Zheng‐tao , Wang Chang‐hong
Published: June 2016

Peganumine B‐I and two enantiomers are isolated.
ChemInform Abstract: Acremonidins F—H and Acremoxanthones F—G, Antimicrobial Substances from the Insect fungus Verticillium sp. BCC33181.
Authors: Intaraudom Chakapong , Bunbamrung Nantiya , Dramae Aibrohim , Boonyuen Nattawut , Komwijit Somjit , Rachtawee Pranee , Pittayakhajonwut Pattama
Published: June 2016

Five new anthraquinone‐xanthone heterodimers (I), (II), and (III) and a new xanthone derivative (IV) are isolated together with eight known compounds.
ChemInform Abstract: C‐F→Ln/An Interactions in Synthetic F‐Element Chemistry
Authors: Yin Haolin , Zabula Alexander V. , Schelter Eric J.
Published: June 2016

Review: 80 refs.
ChemInform Abstract: Coherence and Organisation in Lanthanoid Complexes: From Single Ion Magnets to Spin Qubits
Authors: Gaita‐Arino Alejandro , Prima‐Garcia Helena , Cardona‐Serra Salvador , Escalera‐Moreno Luis , Rosaleny Lorena E. , Baldovi Jose J.
Published: June 2016

Review: 94 refs.
ChemInform Abstract: Coordination‐ and Redox‐Noninnocent Behavior of Ambiphilic Ligands Containing Antimony
Authors: Jones J. Stuart , Gabbai Francois P.
Published: June 2016

Review: 46 refs.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Biologically Important 3‐Hydroxyoxindoles: An Update
Authors: Yu Bin , Xing Hui , Yu De‐Quan , Liu Hong‐Min
Published: June 2016

Review: [85 refs.
ChemInform Abstract: Convenient Methods for the Synthesis of Pentacyclic Fused Heterocycles with Coumarin Moiety
Authors: Govori Sevdije
Published: June 2016

Review: 34 refs.
ChemInform Abstract: Production of C4 and C5 Alcohols from Biomass‐Derived Materials
Authors: Sun Daolai , Sato Satoshi , Ueda Wataru , Primo Ana , Garcia Hermenegildo , Corma Avelino
Published: June 2016

Review: 110 refs.
ChemInform Abstract: Diterpenoids of Gorgonian Corals: Chemistry and Bioactivity
Authors: Lei Hui
Published: June 2016

Review: 95 refs.
ChemInform Abstract: New Caledonia: A Hot Spot for Valuable Chemodiversity. Part 3. Santalales, Caryophyllales, and Asterids
Authors: Coulerie Paul , Poullain Cyril
Published: June 2016

Review: 80 refs.
ChemInform Abstract: Recent Advances in the Synthesis of Benzimidazol(on)es via Rearrangements of Quinoxalin(on)es
Authors: Mamedov Vakhid A.
Published: June 2016

Review: [131 refs.
ChemInform Abstract: Catalytic C—N Bond‐Forming Reactions Enabled by Proton‐Coupled Electron Transfer Activation of Amide N—H Bonds
Authors: Nguyen Lucas Q. , Knowles Robert R.
Published: June 2016

Review: 133 refs.
ChemInform Abstract: Catalytic Reactions with N‐Mesityl‐Substituted N‐Heterocyclic Carbenes
Authors: Mahatthanachai Jessada , Bode Jeffrey W.
Published: June 2016

Review: 186 refs.
ChemInform Abstract: Disruptive Catalysis by Zeolites
Authors: Abate S. , Barbera K. , Centi G. , Lanzafame P. , Perathoner S.
Published: June 2016

Review: 172 refs.
ChemInform Abstract: Natural New Sesquiterpenes: Structural Diversity and Bioactivity
Authors: Li Dan , Wang Kui‐Wu
Published: June 2016

Review: 201 refs.
ChemInform Abstract: The Mechanism of Enantioselective Ketone Reduction with Noyori and Noyori—Ikariya Bifunctional Catalysts
Authors: Dub Pavel A. , Gordon John C.
Published: June 2016

Review: 303 refs.
ChemInform Abstract: Memory of Chirality in Total Synthesis
Authors: Yang Jieun , Ha Hyun‐Joon
Published: June 2016

Review: 4 refs.
ChemInform Abstract: ZrO2 Acting as a Redox Catalyst
Authors: Kauppi E. I. , Honkala K. , Krause A. O. I. , Kanervo J. M. , Lefferts L.
Published: June 2016

Review: 30 refs.
ChemInform Abstract: Quantum Tunneling of the Magnetization in [MnIII6M]3+ (M: CrIII, MnIII) SMMs: Impact of Molecular and Crystal Symmetry
Authors: Glaser Thorsten , Hoeke Veronika , Gieb Klaus , Schnack Juergen , Schroeder Christian , Mueller Paul
Published: June 2016

Review: (SMM: single molecule magnet) emphasis on Mn and Mn/Cr heptanuclear triplesalen complexes; 143 refs.
ChemInform Abstract: 1H‐NMR as a Structural and Analytical Tool of Intra‐ and Inter‐Molecular Hydrogen Bonds of Phenol‐Containing Natural Products and Model Compounds
Authors: Charisiadis Pantelis , Kontogianni Vassiliki G. , Tsiafoulis Constantinos G. , Tzakos Andreas G. , Siskos Michael , Gerothanassis Ioannis P.
Published: June 2016

Review: 75 refs.
ChemInform Abstract: Recent Developments on the Structure—Activity Relationship Studies of MAO Inhibitors and Their Role in Different Neurological Disorders
Authors: Kumar Bhupinder , Sheetal Sheetal , Mantha Anil K. , Kumar Vinod
Published: June 2016

Review: 147 refs.
ChemInform Abstract: Endogenous Stimuli‐Responsive Nanocarriers for Drug Delivery
Authors: Chen Huachao , Liu Danyang , Guo Zijian
Published: June 2016

Review: 76 refs.
ChemInform Abstract: Graphene Oxide Liquid Crystals: Discovery, Evolution and Applications
Authors: Narayan Rekha , Kim Ji Eun , Kim Ju Young , Lee Kyung Eun , Kim Sang Ouk
Published: June 2016

Review: 142 refs.
ChemInform Abstract: Multifunctional Magnetoelectric Materials for Device Applications
Authors: Ortega N. , Kumar Ashok , Scott J. F. , Katiyar Ram S.
Published: June 2016

Review: 207 refs.
ChemInform Abstract: Functionalization of Surfaces with Branched Polymers
Authors: Sun Wei
Published: June 2016

Review: 137 refs.
ChemInform Abstract: Magnetocaloric Effect in Nanoscale Thin Films and Heterostructures
Authors: Miller Casey W. , Belyea Dustin D. , Kirby Brian J.
Published: June 2016

Review: 128 refs.
ChemInform Abstract: Hybrid Density Functionals Applied to Complex Solid Catalysts: Successes, Limitations, and Prospects
Authors: Paier Joachim
Published: June 2016

Review: 338 refs.
ChemInform Abstract: The History of Interferometry for Measuring Diffusion Coefficients
Authors: Miller Donald G.
Published: June 2016

Review: 79 refs.
Besser aromatisch als aliphatisch
Authors: Vogler Herbert
Published: June 2016

In den Labors der britischen Textilfirma Calico Printers Association stellten John Rex Whinfield und James Tennant Dickson vor 75 Jahren erstmals Fasern aus Polyethylenterephthalat her. Sie schufen damit die ersten wirtschaftlich erfolgreichen Polyesterfasern. Vorausgegangen waren Arbeiten des berühmten Faserchemikers Wallace Hume Carothers, der aber keine Fasern mit brauchbaren textilen Eigenschaften auffinden konnte. Carothes arbeitete mit aliphatischen Säuren, der Austausch dieser Säuren durch die aromatische Terephthalsäure führte zum Erfolg von Whinfield und Dickson. Die Entwicklung von großtechnisch einsetzbaren Verfahren zur Herstellung von Polyesterfasern erfolgte bei dem britischen Chemiekonzern ICI sowie bei der amerikanischen Firma Du Pont, die in den frühen 1950er Jahren die ersten Polyesterfasern auf den Markt brachten. Heute sind die Polyesterfasern die Synthesefasern mit den größten Produktionsmengen. Wichtigstes Herstellerland ist die Volksrepublik China.
Synthesis of large‐scale heat exchanger networks using a T‐Q diagram method
Authors: Kang Lixia , Liu Yongzhong , Jiang Nan
Published: June 2016

For design of a heat exchanger network (HEN) by pinch technology, it is not uncommon to determine stream splitting and stream matching by empirical experience, in which numerous attempts are usually required to reach the final configuration of the HEN. In this work, a novel T‐Q diagram method is proposed to integrate large‐scale HENs on the basis of partitioning and merging heat recovery intervals. It aims at reducing the difficulties of the stream matching process for large‐scale HENs. The implementation procedure is illustrated via a simple HEN design problem. Furthermore, the HEN of a vacuum distillation unit in a refinery is used to further demonstrate the advantages and versatility of the proposed method. The results indicate that the proposed method can reduce the computational effort required and obtain a cost‐effective design of large‐scale HENs. Therefore, it provides an effective graphical analysis tool for the integration of large‐scale HENs in practice.
Synthesis and Biological Evaluation of Gem‐Difluoromethylenated Statin Derivatives as Highly Potent HMG‐CoA Reductase Inhibitors
Authors: Zhao Zhao , Cui Jiaxin , Yin Yan , Zhang Heng , Liu Yecheng , Zeng Rui , Fang Chao , Kai Zhenpeng , Wang Zhonghua , Wu Fanhong
Published: June 2016

HMG‐CoA reductase inhibitors were widely used as lipid‐lowing agents through effectively blocking the rate‐limiting step of cholesterol biosynthesis. 8 analogs of Rosuvastatin were firstly prepared with different distance and functional group between the O5‐hydroxyl group and terminal COOH group in the hydrophilic side‐chain. In primary and secondary screening of the inhibitory activities against human HMG‐CoA reductase, gem‐difluoromethylenated derivatives exhibited more than 50% inhibition rate. Then 4 compounds with gem‐difluoro group were further synthesized and evaluated in vitro, three compounds among them exhibited low single digital nmol/L IC50 values against HMG‐CoA reductase. Molecular docking also well explained the observed special contribution of the gem‐difluoro group.
Transversally enriched pipe element method (TEPEM): An effective numerical approach for blood flow modeling
Authors: Mansilla Alvarez Luis , Blanco Pablo , Bulant Carlos , Dari Enzo , Veneziani Alessandro , Feijóo Raúl
Published: June 2016

In this work, we present a novel approach tailored to approximate the Navier–Stokes equations to simulate fluid flow in three‐dimensional tubular domains of arbitrary cross‐sectional shape. The proposed methodology is aimed at filling the gap between (cheap) one‐dimensional and (expensive) three‐dimensional models, featuring descriptive capabilities comparable with the full and accurate 3D description of the problem at a low computational cost. In addition, this methodology can easily be tuned or even adapted to address local features demanding more accuracy. The numerical strategy employs finite (pipe‐type) elements that take advantage of the pipe structure of the spatial domain under analysis. While low order approximation is used for the longitudinal description of the physical fields, transverse approximation is enriched using high order polynomials. Although our application of interest is computational hemodynamics and its relevance to pathological dynamics like atherosclerosis, the approach is quite general and can be applied in any internal fluid dynamics problem in pipe‐like domains. Numerical examples covering academic cases as well as patient‐specific coronary arterial geometries demonstrate the potentialities of the developed methodology and its performance when compared against traditional finite element methods. Copyright © 2016 John Wiley & Sons, Ltd.
Silicon Nanocrystals: It's Simply a Matter of Size
Authors: Sun Wei , Qian Chenxi , Chen Kenneth K. , Ozin Geoffrey A.
Published: June 2016

Composed of one of the most earth abundant, low cost and least toxic elements, silicon nanocrystals exhibit quantum and spatial confinement effects when their size is diminished to that of the exciton, around 5 nm. With the recent discovery of various means for synthesizing and separating silicon nanocrystals into narrow size distribution mono‐dispersions, it became possible for the first time to implement more deeply analytical studies of their size‐dependent chemical, physical and biological properties than was possible with poly‐dispersions. In this article we take a look at some recent studies of mono‐dispersions of silicon nanocrystals where it is apparent that size really matters. With this newfound knowledge we imagine the new directions that the field may take in the future. The topics covered include how silicon nanocrystal size is manifest on their (i) surface structure and reactivity, (ii) optical and electronic properties, (iii) chemical and photochemical stability, and (iv) biochemical and cytotoxicity behavior. The article concludes with a vision of what the future might hold for this important class of nanocrystals.
Mean Curvature Flow of Mean Convex Hypersurfaces
Authors: Haslhofer Robert , Kleiner Bruce
Published: June 2016

In the last 15 years, White and Huisken‐Sinestrari developed a far‐reaching structure theory for the mean curvature flow of mean convex hypersurfaces. Their papers provide a package of estimates and structural results that yield a precise description of singularities and of high‐curvature regions in a mean convex flow.

In the present paper, we give a new treatment of the theory of mean convex (and k‐convex) flows. This includes: (1) an estimate for derivatives of curvatures, (2) a convexity estimate, (3) a cylindrical estimate, (4) a global convergence theorem, (5) a structure theorem for ancient solutions, and (6) a partial regularity theorem.

Our new proofs are both more elementary and substantially shorter than the original arguments. Our estimates are local and universal. A key ingredient in our new approach is the new noncollapsing result of Andrews [2]. Some parts are also inspired by the work of Perelman [32,33]. In a forthcoming paper [17], we will give a new construction of mean curvature flow with surgery based on the methods established in the present paper.

Note added in May 2015. Since the first version of this paper was posted on arxiv in April 2013, the estimates have been used to construct mean convex flow with surgery in ℝ3 by Brendle and Huisken [5] in September 2013 and in another paper by the authors in April 2014.© 2016 Wiley Periodicals, Inc.
Use of Nuclear Spin Noise Spectroscopy to Monitor Slow Magnetization Buildup at Millikelvin Temperatures
Authors: Pöschko Maria Theresia , Peat David , Owers‐Bradley John , Müller Norbert
Published: June 2016

At ultralow temperatures, longitudinal nuclear magnetic relaxation times become exceedingly long and spectral lines are very broad. These facts pose particular challenges for the measurement of NMR spectra and spin relaxation phenomena. Nuclear spin noise spectroscopy is used to monitor proton spin polarization buildup to thermal equilibrium of a mixture of glycerol, water, and copper oxide nanoparticles at 17.5 mK in a static magnetic field of 2.5 T. Relaxation times determined in such a way are essentially free from perturbations caused by excitation radiofrequency pulses, radiation damping, and insufficient excitation bandwidth. The experimental spin‐lattice relaxation times determined on resonance by saturation recovery with spin noise detection are consistently longer than those determined by using pulse excitation. These longer values are in better accordance with the expected field dependence trend than those obtained by on‐resonance experiments with pulsed excitation.
Conformational Dynamics of the Single Lipopolysaccharide O‐Antigen in Solution
Authors: Galochkina Tatiana , Zlenko Dmitry , Nesterenko Alexey , Kovalenko Ilya , Strakhovskaya Marina , Averyanov Alexander , Rubin Andrey
Published: June 2016

The O‐antigen is the most variable and highly immunogenic part of the lipopolysaccharide molecule that covers the surface of Gram‐negative bacteria and makes up the first line of cellular defense. To provide insight into the details of the O‐antigen arrangement on the membrane surface, we simulated its behavior in solution by molecular dynamics. We developed the energetically favorable O‐antigen conformation by analyzing free‐energy distributions for its disaccharide fragments. Starting from this conformation, we simulated the behavior of the O‐antigen chain on long timescales. Depending on the force field and temperature, the single molecule can undergo reversible or irreversible coil‐to‐globule transitions. The mechanism of these transitions is related either to the rotation of the carbohydrate residues around O‐glycosidic bonds or to flips of the pyranose rings. We found that the presence of rhamnose in the O‐antigen chain crucially increases its conformational mobility.
Dynamical analysis and numerical simulation of bloch chaotic system
Authors: Zhang Fuchen , Liao Xiaofeng , Zhang Guangyun , Mu Chunlai , Lin Da
Published: June 2016

In this article, some dynamics of Bloch chaotic system have been studied. Based on Lagrange multiplier method, optimization theory, and the generalized positively definite and radially unbound Lyapunov functions with respect to the parameters of the system, we derive the ultimate bound and a family of mathematical expressions of globally exponentially attractive sets for this system with respect to the parameters of system. The results obtained in this article provides theory basis for chaotic synchronization, chaotic control, Hausdorff dimension, and Lyapunov dimension of chaotic attractors of Bloch chaotic system. © 2016 Wiley Periodicals, Inc. Complexity 21: 201–206, 2016
Ontogeny of Hepatic Drug Transporters as Quantified by LC‐MS/MS Proteomics
Authors: Prasad B , Gaedigk A , Vrana M , Gaedigk R , Leeder JS , Salphati L , Chu X , Xiao G , Hop CECA , Evers R , Gan L , Unadkat JD
Published: June 2016

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n = 69) and adult (n = 41) livers was quantified by liquid chromatography / tandem mass spectroscopy (LC‐MS/MS). Transporter protein expression of OCT1, OATP1B3, P‐gp, and MRP3 was age‐dependent. Particularly, significant differences were observed in transporter expression (P < 0.05) between the following age groups: neonates vs. adults (OCT1, OATP1B3, P‐gp), neonates or infants vs. adolescents and/or adults (OCT1, OATP1B3, and P‐gp), infants vs. children (OATP1B3 and P‐gp), and adolescents vs. adults (MRP3). OCT1 showed the largest increase, of almost 5‐fold, in protein expression with age. Ontogenic expression of OATP1B1 was confounded by genotype and was revealed only in livers harboring SLCO1B1*1A/*1A. In livers >1 year, tissues harboring SLCO1B1*14/*1A showed 2.5‐fold higher (P < 0.05) protein expression than SLCO1B1*15/*1A. Integration of these ontogeny data in physiologically based pharmacokinetic (PBPK) models will be a crucial step in predicting hepatic drug disposition in children.
Renewable Gasoline, Solvents, and Fuel Additives from 2,3‐Butanediol
Authors: Harvey Benjamin G. , Merriman Walter W. , Quintana Roxanne L.
Published: June 2016

2,3‐Butanediol (2,3‐BD) is a renewable alcohol that can be prepared in high yield from biomass sugars. 2,3‐BD was selectively dehydrated in a solvent‐free process to a complex mixture of 2‐ethyl‐2,4,5‐trimethyl‐1,3‐dioxolanes and 4,5‐dimethyl‐2isopropyl dioxolanes with the heterogeneous acid catalyst Amberlyst‐15. The purified dioxolane mixture exhibited an anti‐knock index of 90.5, comparable to high octane gasoline, and a volumetric net heat of combustion 34 % higher than ethanol. The solubility of the dioxolane mixture in water was only 0.8 g per 100 mL, nearly an order of magnitude lower than the common gasoline oxygenate methyl tert‐butyl ether. The dioxolane mixture has potential applications as a sustainable gasoline blending component, diesel oxygenate, and industrial solvent.
Personality psychopathology differentiates risky behaviors among women with bulimia nervosa
Authors: Pearson Carolyn M. , Pisetsky Emily M. , Goldschmidt Andrea B. , Lavender Jason M. , Wonderlich Stephen A. , Crosby Ross D. , Engel Scott G. , Mitchell James E. , Crow Scott J. , Peterson Carol B.
Published: June 2016

Objective

Individuals with bulimia nervosa (BN) frequently endorse risky behaviors such as self‐harm and substance use. However, no studies of BN to date have examined factors associated with engaging in individual or co‐occurring risky behaviors. Given that individuals with BN often have personality psychopathology, which has been linked to symptoms and course of illness, this study sought to examine how personality may differentiate engagement in risky behaviors among BN individuals.

Method

A sample of 133 women with BN completed self‐report measures of personality psychopathology at baseline, and then reported on bulimic and risky behaviors (e.g., substance misuse, self‐harm) over 2 weeks using ecological momentary assessment. A series of hierarchical multiple regression analyses were conducted to examine the unique associations between state‐level predictor variables (each risky behavior, e.g., substance misuse, and combination of risky behaviors, e.g., substance misuse plus self‐harm) and trait‐level personality constructs.

Results

Substance misuse behavior, above and beyond all other risky behaviors, was significantly associated with higher scores on trait dissocial behavior (P = 0.004).

Discussion

Substance misuse in BN has a unique association with dissocial behavior, a personality trait characterized by hostility, impulsivity, and entitlement. These results suggest that targeting personality variables may help facilitate more effective treatment of risky behaviors, including substance use in BN. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:681–688)
A test for within‐lake niche differentiation in the nine‐spined sticklebacks (Pungitius pungitius)
Authors: Calboli Federico C. F. , Byström Pär , Merilä Juha
Published: June 2016

Specialization for the use of different resources can lead to ecological speciation. Accordingly, there are numerous examples of ecologically specialized pairs of fish “species” in postglacial lakes. Using a polymorphic panel of single nucleotide variants, we tested for genetic footprints of within‐lake population stratification in nine‐spined sticklebacks (Pungitius pungitius) collected from three habitats (viz. littoral, benthic, and pelagic) within a northern Swedish lake. Analyses of admixture, population structure, and relatedness all supported the conclusion that the fish from this lake form a single interbreeding unit.
Groundwater recharge decrease with increased vegetation density in the Brazilian cerrado
Authors: Oliveira Paulo Tarso S. , Leite Marcelo Boccia , Mattos Tiago , Nearing Mark A. , Scott Russell L. , de Oliveira Xavier Rafael , da Silva Matos Dalva Maria , Wendland Edson
Published: June 2016

Large areas of the Brazilian savanna (cerrado) have been converted into farmland in recent years; however, little attention has been paid to the consequences of this land use and land cover change on groundwater recharge. Here, we assessed groundwater recharge in different physiognomies of the cerrado located in an outcrop area of the Guarani Aquifer System. Water table fluctuations were measured from October 2011 through August 2013, by 58 monitoring wells distributed on four physiognomies of the undisturbed cerrado. We used multiple monitoring wells located in “campo limpo” (cerrado grassland), “campo sujo” (shrub cerrado), “campo cerrado” (open wooded cerrado), and “cerrado sensu stricto” (wooded cerrado), cover types. Recharge rates were computed for each well using the water table fluctuation method. The measured precipitation for hydrological years 2011–2012 and 2012–2013 were 1247 and 1194 mm, respectively. We found values of average annual recharge of 363 ± 87 mm, 354 ± 85 mm, 324 ± 78 mm, and 315 ± 76 mm for “campo limpo,” “campo sujo,” “campo cerrado,” and “cerrado sensu stricto,” respectively. Our results suggest that recharge tends to decrease with the increase in the density of vegetation (grassland to woodland). These results indicate that water table depth may have an influence on the cerrado physiognomies or vice versa. Furthermore, replacement of undisturbed dense cerrado with croplands will likely alter recharge dynamics. Therefore, sound management of land use and land cover is needed to ensure future groundwater quantity and quality.
Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level
Authors: Banti Christina N. , Hadjikakou Sotiris K.
Published: June 2016

The nonsteroidal anti‐inflammatory drugs (NSAIDs) make up a great group of drugs that provide benefits in the prevention of cancers. Coordinated metal ions with NSAIDs provide advantages over the drugs themselves. The metal complexes of NSAIDs display a range of biological activities quite often inaccessible to the original NSAID ligands. NSAIDs‐metal complexes have molecular properties different from those of the parent drugs. Thus, if a given NSAIDs‐metal complex remains intact in the biological medium its biological target is almost invariably different from the original NSAID target. This review includes results obtained on the antibacterial and antiproliferative activities of metal‐NSAIDs complexes and their interaction with intracellular components. The study shows that the molecular weights of metal complexes containing the same NSAID are linearly related to their IC50 values against MCF‐7 cells. Moreover, compounds with low molecular weight strongly bind to DNA.
Mononuclear Iron Complexes with Tetraazadentate Ligands as Water Oxidation Catalysts
Authors: Panchbhai Gayatri , Singh Wangkheimayum Marjit , Das Biswanath , Jane Reuben T. , Thapper Anders
Published: June 2016

Two iron(II) complexes with tetraazadentate ligands have been synthesised, characterised and evaluated as water oxidation catalysts. The two ligands, N,N′‐diisopropyl‐N,N′‐bis(2‐pyridylmethyl)‐1,2‐diaminoethane (1), and N‐methyl‐N‐(2‐pyridinylmethyl)‐2,2′‐bipyridine‐6‐methanamine (2), both give iron(II) complexes (1Fe and 2Fe, respectively) with an octahedral coordination geometry with two labile triflate ligands in a cis configuration in the crystal structures. When treated with cerium(IV) as a chemical oxidant in aqueous solution at room temperature the complexes form semi‐stable FeIV(O) species that can be detected in the UV/Visible region. Both 1Fe and 2Fe can act as catalysts for water oxidation when treated with a large excess of oxidant, but 1Fe is a better catalyst than 2Fe. Possible geometrical factors behind this difference in reactivity are discussed and compared with literature data.
Increased Selectivity in CO2/CH4 Separation with Mixed‐Matrix Membranes of Polysulfone and Mixed‐MOFs MIL‐101(Cr) and ZIF‐8
Authors: Tanh Jeazet Harold B. , Sorribas Sara , Román‐Marín José M. , Zornoza Beatriz , Téllez Carlos , Coronas Joaquín , Janiak Christoph
Published: June 2016

Combination of two hydrothermally stable MOFs MIL‐101(Cr) and ZIF‐8 in a 1:1 ratio in a polysulfone (PSF) mixed‐matrix membrane (MMM) showed a significant higher selectivity in mixed‐gas CO2/CH4 permeation tests for 16 wt.‐% MIL‐101(Cr)/ZIF‐8 compared to analogous single‐filler MMMs [MIL‐101(Cr) or ZIF‐8] or to the also tested combination NH2‐MIL‐53(Al)/ZIF‐8 (1:1 ratio). The CO2/CH4 selectivity increased significantly from 23 to 40 from pure PSF to the 16 wt.‐% MIL‐101(Cr)/ZIF‐8 membrane. Separation of CO2/CH4 is relevant for purification (“sweetening”) of natural gas (CH4 as main component) which is soured with up to over 40 % CO2 and N2 and only useable at low CO2 concentrations.
Spin Modulation in Highly Distorted FeIII Porphyrinates by Using Axial Coordination and Their π‐Cation Radicals
Authors: Sahoo Dipankar , Guchhait Tapas , Rath Sankar Prasad
Published: June 2016

A series of five‐coordinate FeIII octaaryltetraphenylporphyrins [FeIII(por)(X)] (X = Cl, I, I3, ClO4, or SO3CF3) and their 1 e–‐oxidized complexes [FeIII(por·)(X)(Y)] (X = Cl, I, ClO4, or SO3CF3; Y = SbCl6, I3, ClO4, or SO3CF3) have been synthesized and characterized. The electronic structures have been confirmed by using UV/Vis, IR, 1H NMR, EPR, and Mössbauer spectroscopy as well as signal‐crystal X‐ray diffraction studies. The neutral five‐coordinate complexes exhibit spin states ranging from essentially pure high spin (S = 5/2 with X = Cl), admixed intermediate spin (S = 5/2, 3/2 with X = I) to an essentially pure intermediate spin (S = 3/2 with X = I3, ClO4, and SO3CF3) depending upon the axial ligand field strength. The average Fe–Np length decreases with decreasing axial ligand strengths, Cl < I < ClO4 < I3 ≈ SO3CF3, which happens to be the order of increasing contributions of the intermediate‐spin state to the complexes. DFT calculations demonstrate a dramatic change in the orbital energy levels upon changing the axial ligand strength. Upon 1 e– oxidation, the high‐spin chloro complex forms the five‐coordinate high‐spin FeIII porphyrin π‐cation radical, whereas the essentially pure intermediate perchlorato, triflato, triiodo iron(III) porphyrinates produce the corresponding six‐coordinate high‐spin iron(III) porphyrin π‐cation radicals. The oxidation also induces larger separation between the up‐ and down‐field shifted methylene resonances in the 1H NMR spectra owing to the presence of the π‐cation radical.
Quantitative Structure–Property Relationship Models for Recognizing Metal Organic Frameworks (MOFs) with High CO2 Working Capacity and CO2/CH4 Selectivity for Methane Purification
Authors: Aghaji Mohammad Zein , Fernandez Michael , Boyd Peter G. , Daff Thomas D. , Woo Tom K.
Published: June 2016

Metal‐organic frameworks (MOFs) can theoretically yield a nearly infinite number of nanoporous materials, which represents a combinatorial design challenge that demands computational tools rather than experimental trial‐and‐error. Here we report Quantitative Structure–Property Relationship (QSPR) models to identify high‐performing MOFs for methane purification solely using geometrical features. The CO2 working capacity and CO2/CH4 selectivity of ca. 320,000 hypothetical MOF structures was computed at conditions relevant to natural gas purification using grand canonical Monte‐Carlo (GCMC) simulations. Using 32,500 MOF structures we calibrated binary decision tree (DT) and support vector machine (SVM) models that can accurately identify high‐performing MOFs based on their pore size, void fraction and surface area. DT models yielded guidelines of pore size, void fraction and surface area for designing high‐performing materials. The SVM machine learning classifiers could be used to quickly pre‐screen MOFs, such that compute intensive GCMC simulations are not performed on all structures. The SVM classifiers were tested on ca. 290,000 MOFs that were not part of the training set and could correctly identify up to 90 % of high‐performing MOFs while only flagging a fraction of the MOFs for more rigorous screening. QSPR models constitute efficient computational tools for the virtual screening of large structural libraries and provide rational design rules for the discovery of sorbents for methane purification.
Template Synthesis of Alkyl‐Substituted Metal Isocorroles
Authors: Hoffmann Martin , Cordes Birte , Kleeberg Christian , Schweyen Peter , Wolfram Benedikt , Bröring Martin
Published: June 2016

Five metal complexes of 10,10‐dimethylisocorrole ligands with full β‐pyrrolic substitution is have been synthesized. The preparation of nickel(II), palladium(II), and copper(II) complexes was achieved by metal‐templated oxidative macrocyclization of tetrapyrrolic 5,15‐biladiene precursors. The reaction conditions for successful macrocycle formation in yields of 18–32 % depended strongly on the type of metal ion used. In the case of palladium, three different macrocyclic products were observed by varying the cyclization protocol. The ring‐contracted metal 10‐isocorroles were fully characterized by single‐crystal X‐ray diffraction, optical and resonance spectroscopy, and electrochemical methods. All the compounds belong to the class of nonaromatic porphyrinoids and their structural and spectroscopic properties as well as their redox behavior were found to show the characteristic features of both ring‐contracted aromatic porphyrinoids and linear tetrapyrrole complexes.
Chiral Phosphinoferrocenyl‐Calixarenes
Authors: Karpus Andrii , Yesypenko Oleksandr , Boiko Vyacheslav , Poli Rinaldo , Daran Jean‐Claude , Voitenko Zoia , Kalchenko Vitaly , Manoury Eric
Published: June 2016

The Mitsunobu alkylation of 4‐tert‐butylcalix[4]arene with (S)‐(2‐diphenylthiophosphinoferrocenyl)methanol followed by desulfuration of the thiophosphine unit using tris(dimethylamino)phosphine afforded enantiomerically pure calixarene mono‐ and di(ferrocenylphosphine) ligands in high yields. The calixarene mono(ferrocenylphosphine) ligands exhibited good catalytic activity but low atropoenantioselectivity when used in the asymmetric Suzuki–Miyaura coupling reaction of 1‐naphthaleneboronic acid and 1‐bromo‐2‐methylnaphthalene. However, the di(ferrocenylphosphine) ligand displayed both good catalytic activity and enantioselectivity (ee values up to 86 %) when employed in the asymmetric Tsuji–Trost allylic alkylation of 1,3‐diphenylprop‐2‐enyl acetate with dimethyl malonate.