bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Value Dimensions in Public Satisfaction with Primary Health Care: Prospective Observational Study
Authors: Mazunina S. D. , Petrov S. B. , Melkonian K. I. , Veselova D. V.
Published: April 2023

Background. Artificial neural network models can be used to analyze and predict structural components within the value dimension of the main processes in an outpatient clinic as indicators of patient satisfaction.

Objective — to form and test the methodology for analyzing and predicting structural components within the value dimension of the main processes in an outpatient clinic, as indicators of patient satisfaction with availability and quality of medical care, using artificial intelligence.

Methods. The results of questionnaires administered to 525 patients were used to analyze their satisfaction with GP appointments. A network ensemble consisting of radial basis network and multilayer perceptron was chosen as the basis for a neural network model. The model testing involved five outpatient clinics in Kirov. The total number of respondents comprised 217 patients. Statistical processing included data description and analysis. Qualitative attributes were represented by relative values (P, %). The statistical significance of differences in qualitative data was assessed using the Chi-square test. The correlation between the observed and predicted data was assessed by means of nonparametric Spearman correlation analysis. The value of p <0.05 was chosen as the significance level ( p). Statistical data processing was performed using Statistica 13.0.

Results. Analysis of the value dimensions of satisfaction showed a predominance of “pre-appointment” stage: work of a registrar (85.29% significance in the receiving medical services), waiting time for an appointment with a doctor (66.76% respondents noted its significance), duration of waiting directly at the office (important for 69.11% of respondents). “Appointment” stage was formed according to the common procedure of a GP appointment (interview, examination, recommendations) and was assessed from the value perspective of the patient. The priority components included sufficiency of appointment duration (significant in 88.27% of cases), satisfaction with examination (significant in 85.14% of cases), as well as completeness and informativeness of consultation (significant in 89.9% of cases). A strong direct correlation between the observed and predicted data (ρxy = 0.9; p < 0.05) was found out. Statistically significant differences between the observed and predicted levels of general patient satisfaction were not revealed in all medical organizations.

Conclusion. The suggested neural network models can be used as the basis when creating information management systems that monitor meeting the effectiveness criteria for a new model of a medical organization; as well as an essential support for administrative decisions related to organizing the optimal patient management.
Dynamic Characteristics of Medical and Demographic Indicators of Public Health in Arkhangelsk Oblast in the First Twenty Years of the XXI Century: Retrospective Analytical Descriptive Study
Authors: Shelygin K. V. , Sumarokov Yu. A.
Published: April 2023

Background. Assessing the dynamic characteristics of basic public health indicators is essential to ensure the sustainable human development, quality of life and health care system performance in the Arctic and Subarctic regions of Russia. The study is based on the need for constant monitoring of the medical and demographic situation in order to provide timely correction of measures for improving the health care system performance.

Objective — to assess the trends in basic medical and demographic indicators characterizing the population health of the Arkhangelsk Oblast. Target population: population of the Arkhangelsk Oblast, no impacts, no outcomes.

Methods. Criteria for sample or group formation: the research was performed by means of a continuous method based on the study of population of medical and demographic events. The main inclusion criterion was the availability of information about a medical and demographic event in the Arkhangelsk Oblast in the Russian Fertility and Mortality database (RusFMD), the database of the Federal State Statistics Service (Rosstat). Estimated parameters: life expectancy, infant mortality, disability, morbidity, natural population growth and chronicity rates related to the population of the Arkhangelsk Oblast excluding the Nenets Autonomous Okrug. The study was conducted between 2021 and 2022. The following measurement methods were used: autoregressive and integrated moving average, Irwin method to identify abnormal values, linear regression, time series dynamics, and method of chain substitutions. The research was performed by means of a continuous method based on studying the population of medical and demographic events.

Results. Natural population growth and chronicity rates showed a stable negative trend, which indicated a decrease in the reproduction potential of the population, and an increase in chronic forms of diseases. Life expectancy, primary morbidity, and primary disability demonstrated a positive trend, but with a tendency to exhaust the positive potential. Infant mortality was the only indicator that consistently showed a positive trend. No additional results of the research were reported.

Conclusion. The results of the study demonstrated the deterioration in population health of the Arkhangelsk Oblast, which may be due to a decline in living standards and quality of life as well as to a decrease in health care system performance and a rise in its dysfunctionality. The study has no limitations.
Novel 1,4-Dihydropyridine Derivatives as Potential Agents with Analgesic Activity IN Orofacial Trigeminal Pain Test: Experimental Preclinical Randomized Trial
Authors: Bibik E. Yu. , Oleynik I. S. , Pankov A. A. , Frolov K. A. , Dotsenko V. V. , Krivokolysko S. G.
Published: April 2023

Background.In the majority of cases, contemporary pharmacological correction mainly focuses on the most effective analgesia. Therefore, the search for and research into new analgesic drugs are a priority in modern pharmacology.

Objective— to establish the level of analgesic activity in eight novel heterocyclic compounds of 1,4-dihydropyridine derivatives synthesized in a classic test of orofacial trigeminal pain in animal experiments.

Methods.An experimental preclinical randomized trial of the analgesic activity in 1,4-dihydropyridine derivatives was carried out. The experiment was conducted on 100 white male outbred rats in the laboratory of the Fundamental and Clinical Pharmacology Department, St. Luke Lugansk State Medical University, Lugansk People’s Republic. Novel 1,4-dihydropyridine derivatives were preliminarily investigated in a virtual biological screening by means of Swiss Target Prediction tool (Swiss Institute of Bioinformatics, Switzerland). The laboratory animals were divided into a control group (rats were exposed to acute pain syndrome by injecting 0.1 ml of 5% formalin solution into the vibrissae area without pharmacological correction), a comparison group (rats which received metamizole sodium (OOO Farmstandard) at a dose of 7 mg/kg 1.5 hour prior to acute pain syndrome modeling in the vibrissae area), and eight experimental groups (1.5 hours before formalin administration, novel 1,4-dihydropyridine derivatives under study at a dose of 5 mg/ kg were intragastrically injected). 10, 15 and 20 minutes after simulating acute pain, the number of scratching movements of the forelegs around orofacial region per minute was counted. Statistical processing of the results involved methods of mathematical statistics for quantitative variability and was carried out using Statistica 12.5 (IBM, USA).

Results.Animals treated with 1,4-dihydropyridine derivativesd02-133and d02-172 under the experimental conditions showed a significant (13–21 times) decrease in scratching movements frequency by the 10th minute of observation in comparison with the control group. By 15th minute, the analgesic activity of the cyanothioacetamide derivatives increased 14 and 11 times as compared to these indicators of the reference group. After 20 minutes, the analgesic activity of these compounds in terms of inhibiting nociceptive impulses, as compared to the control group, was also high, as the number of scratching movements in the vibrissae area in animals of these experimental groups was 8–9 times lower than in control group. The orofacial trigeminal pain test detected the most exhibited analgesic activity in novel cyanothioacetamide derivativesd02-139,d02-133, andd02-172,which appeared to be higher than that of metamizole sodium.

Conclusion.It was found that novel original derivatives of 1,4-dihydropyridine showed a high degree of analgesic activity.
Os conselhos de acompanhamento e controle social no FUNDEB permanente
Authors: Ribeiro Misael Hipólito , Araujo José Carlos Souza
Published: April 2023

Objetivo: O objetivo deste trabalho é analisar as principais características do Conselho de Acompanhamento e Controle Social (CACS) no monitoramento, controle e fiscalização dos recursos públicos criado pela (EC) Emenda Constitucional n°108 de 27 de agosto de 2020 e regulamentado infraconstitucionalmente pela Lei n° 14.113, de 25 de dezembro de 2020, que regulamenta o Fundo de Manutenção e Desenvolvimento da Educação Básica e de Valorização dos Profissionais da Educação (FUNDEB), de que trata o art. 212-A da Constituição Federal. Revisão bibliográfica: Nesse sentido, analisa se o CACS atinge os objetivos traçados na legislação. A delimitação metodológica deste trabalho fundeia-se em uma abordagem qualitativa, pois os resultados trarão aspectos qualitativos, bem como quantitativos sobre os temas apontados na pesquisa de fonte documental e referencial bibliográfico sobre a temática. Portanto, realiza-se um trabalho de revisão bibliográfica. Considerações finais: Desse modo, os dados que embasam o presente estudo apontam que a E.C 108/20 e a Lei n° 14.113/20 impuseram aos integrantes do CACS ações múltiplas e complexas no planejamento de políticas públicas educacionais de acordo com as esferas governamentais que se vinculam sendo necessário investimento público na formação continuada dos integrantes dos Conselhos de Acompanhamento.
Alimcan Ablet, Çin-İsrail İlişkileri, İstanbul: İyidüşün Yayınları, (Mayıs 2021), ss. 208.
Authors: YILDIZ Melih
Published: April 2023

20. yüzyılın son çeyreğine kadar geri kalmış bir ülke profili çizen Çin 1970’lerin sonunda gerçekleştirmeye başladığı reformlar ile büyük bir dönüşüm ve gelişim dönemine girmiştir. Çin’i hızla modernleştiren bu süreç aynı zamanda Pekin’in ekonomik ve askeri kapasitesini de hızla artırmasına olanak sağlamıştır. Bu durum ise Çin’in özellikle 21. yüzyılın başından itibaren küresel ölçekte etkili bir dış politika yürütmesine imkan sağlamaktadır. Pekin bu yeni dönemde daha önce sınırlı ilişkilere sahip olduğu ülkelerle ilişkilerini geliştirmektedir. Alimcan Ablet’in Çin-İsrail İlişkileri adlı kitabı Pekin’in, ilişkilerini hızla geliştirmeye başladığı ülkelerden biri olan İsrail ile ilişkilerini incelemektedir.
Pyoverdine Analysis – From High-resolution MS/MS Fragmentation to Ion Mobility Measurements
Authors: Rehm Karoline , Vollenweider Vera , Kümmerli Rolf , Bigler Laurent
Published: April 2023

Microorganisms produce iron chelators called siderophores that are a rich source for drug discovery or plant protective agents. Pyoverdines are a class of siderophores from fluorescent Pseudomonas members and consist of different peptide chains specific to each bacterial species. The structural elucidation and characterization of pyoverdines require comprehensive analytical methods as bacterial extracts are complex mixtures. Here, we present a high-throughput UHPLC-MS/MS pipeline and the application of ion mobility spectrometry to facilitate research in the field of medicine and agriculture.
Updates on moleculARweb, the Swiss Portal for Chemistry and Structural Biology Education Using Augmented and now also Virtual Reality
Authors: Cortés Rodríguez Fabio , Dualde Facundo , Massiot Philippe , Frattini Gianfranco , Moreno Diego M. , Abriata Luciano A.
Published: April 2023

We present a new activity on the moleculARweb platform on molecular symmetry elements, two more languages, a new marker-less augmented reality mode, and a new virtual reality tool for VR headsets.
Didactic possibilities of using symbols in a foreign language course in non-linguistic universities
Authors: Башеров О.И. , Еферова А.Р. , Яковлева Г.П. , Калашникова Н.А.
Published: April 2023

В современном мире цифровых технологий овладения иностранным языком студентами нелингвистических высших учебных заведений неразрывно связано со специфическими умениями присутствовать в виртуальной среде и общаться онлайн реалиями, понимать символику электронного дискурса. Поэтому задача преподавателя заключается в повышении уровня мультимодальной грамотности студентов. Актуальность исследования связана не только с проблемой решения эмоционального аспекта иноязычного общения студентов нелингвистических заведений, но и с современными цифровыми реалиями, которые должны способствовать учебному процессу и мотивационному прогрессу в овладении языком. Эмодзи не считаются отдельным языком, они играют роль эмотивного дополнения к речи. А поскольку это так, то они могут помогать и в изучении языка. Статья нацелена на изучение возможностей использования языка иконической атрибутики в курсе иностранного языка. Особенности электронной коммуникации в том, что она пользуется знаковой символикой, не характерной для традиционной письменной речи, а именно эмодзи, с помощью которых передают эмоции и другие понятия. Цифровые технологии ворвались во все сферы жизни человека, поэтому не могли обойти и сферу образования.

In the modern world of digital technologies, the acquisition of a foreign language by students of nonlinguistic higher educational institutions is inextricably linked with specific skills to be present in a virtual environment and communicate online realities, to understand the symbolism of electronic discourse. Therefore, the task of the teacher is to increase the level of multimodal literacy of students. The relevance of the research is connected not only with the problem of solving the emotional aspect of foreign language communication of students of non-linguistic institutions, but also with modern digital realities that should contribute to the educational process and motivational progress in language acquisition. Emojis are not considered a separate language, they play the role of an emotive complement to speech. And since this is the case, they can also help in learning the language. The article is aimed at exploring the possibilities of using the language of iconic attributes in a foreign language course. The peculiarities of electronic communication are that it uses symbolic symbols that are not characteristic of traditional written speech, namely emojis, with which emotions and other concepts are conveyed. Digital technologies broke into all spheres of human life, so they could not bypass the sphere of education.
Ageing of High Energy Density Automotive Li-ion Batteries: The Effect of Temperature and State-of-Charge
Authors: Mikheenkova Anastasiia , Smith Alexander J. , B. Frenander Kristian , Tesfamhret Yonas , Roy Chowdhury Niladri , Tai Cheuk-Wai , Thiringer Torbjörn , Wreland Lindström Rakel , Hahlin Maria , Lacey Matthew J.
Published: April 2023

Lithium ion batteries (LIB) have become a cornerstone of the shift to electric transportation. In an attempt to decrease the production load and prolong battery life, understanding different degradation mechanisms in state-of-the-art LIBs is essential. Here, we analyze how operational temperature and state-of-charge (SoC) range in cycling influence the ageing of automotive grade 21700 batteries, extracted from a Tesla 3 Long Range 2018 battery pack with positive electrode containing LiNixCoyAlzO2 (NCA) and negative electrode containing SiOx-C. In the given study we use a combination of electrochemical and material analysis to understand degradation sources in the cell. Herein we show that loss of lithium inventory is the main degradation mode in the cells, with loss of material on the negative electrode as there is a significant contributor when cycled in the low SoC range. Degradation of NCA dominates at elevated temperatures with combination of cycling to high SoC (beyond 50%).
Techno-economic analysis of a CO2 direct air capture-cooling tower hybrid process at a geothermal facility
Authors: Rosner Fabian , Schamberger Alexandre , Breunig Hanna
Published: April 2023

Direct air capture (DAC) of CO2 can play a crucial role in global efforts to manage atmospheric concentrations of CO2, but the current cost-of-capture is prohibitively high. In this work we present a new DAC concept whereby cooling towers at geothermal power plants are hybridized to capture CO2 at very low cost. The system design is elegant in its ability to overcome key technical challenges and highlights the potential for using existing infrastructure to lower DAC cost and land footprint, and secure utilities and public confidence. The techno-economic analysis suggests a cost-of-capture of $100 per metric tonne of CO2 is feasible, allowing geothermal facilities to increase their net profit by $29 per metric tonne of CO2 captured — or $6 million per year — under the 45Q tax credit. If deployed at geothermal facilities in the United States, a net reduction of 270 million tonne CO2 per year is possible by 2050.
Inferring the nominal molecular mass of an analyte from its electron ionization mass spectrum
Authors: Moorthy Arun , Kearsley Anthony , Mallard William , Wallace William , Stein Stephen
Published: April 2023

The performance of three algorithms for predicting nominal molecular mass from an analyte’s electron ionization mass spectrum are presented. The Peak Interpretation Method (PIM) attempts to quantify the likelihood that a molecular ion peak is contained in the mass spectrum, whereas the Simple Search Hitlist Method (SS-HM) and iterative Hybrid Search Hitlist Method (iHS-HM) leverage results from mass spectral library searching. These predictions can be employed in combination (recommended) or independently. The methods were tested on two sets of query mass spectra searched against libraries that did not contain reference mass spectra of the same compounds: 19,074 spectra of various organic molecules searched against NIST17 mass spectral library, and 162 spectra of small molecule drugs searched against SWGDRUG version 3.3. Individually, each molecular mass prediction method had computed precisions (the fraction of positive predictions that were correct) of 91 %, 89 % and 74 %, respectively. The methods become more valuable when predictions are taken together as an ensemble. When all three predictions were identical, which occurred in 33% of the test cases, the predicted molecular mass was almost always correct (> 99 %).
Quantum Zeno Effect: Irreversible and Quantum Thermodynamic considerations
Authors: Lucia Umberto
Published: April 2023

The Quantum Zeno Effect slows down the quantum system's time evolution under frequent measurements. This paper aims to study this quantum effect by introducing the definition of time based on an irreversible thermodynamic analysis of quantum systems. Consequently, the Quantum Zeno Effect requires (i) high values of the electromagnetic entropy generation rate related to the spontaneously down-converted light and (ii) a decrease in the quantum system's entropy value. So, the Quantum Zeno Effect is a quantum process related to the interaction between a quantum system and the electromagnetic waves of the measurement device, causing a quantum thermodynamic stationary state. Last, the fundamental role of irreversibility emerges.
Respiratory disorders of post-COVID-19 syndrome
Authors: Leshchenko Igor V. , Esaulova Natalia A. , Glushkova Tatyana V. , Skornyakov Sergey N.
Published: April 2023

Aim. Assess the functional state of trespiratory system and effectiveness of therapeutic tactics for broncho-obstructive syndrome (BOS) in patients in the post-COVID period.
Materials and methods. A two-center cohort prospective study included 10 456 and 89 patients, respectively. A comprehensive assessment of the respiratory system included clinical, laboratory and functional data, spirometry, body plethysmography, and a study of diffusive capacity of the lungs (DLCO). Therapy consisted of budesonide suspension or fixed combination beclomethasone dipropionate/formoterol (EMD BDP/FORM).
Results. The frequency of BOS in the cohort was 72% (7497 patients). In 13% (n=974) of cases, bronchial asthma was diagnosed for the first time, in 4.4% (n=328) chronic obstructive pulmonary disease. Risk factors for the development and decrease in DLCO in the post-COVID period were identified. In the group of complex instrumental examination of lung function, the absence of violations of spirometric data and indicators determined by body plethysmography was determined.
Conclusion. Risk factors for BOS in post-COVID period are atopy, a history of frequent acute respiratory infections, smoking, blood eosinophilia, moderate and severe forms of COVID-19. The advantage of a fixed combination of EMD BDP/FORM in MART mode compared with nebulized suspension budesonide + solution of salbutamol in treatment of BOS was shown. Risk factors for DLCO disorders were established: severe COVID-19, hospitalization in the intensive care unit, the need for additional oxygen therapy.
Difficult case of differential diagnosis of partial lung atelectasis. Case report
Authors: Gordeeva Olga M. , Egorova Anna D. , Chesalina Yana O. , Gretcov Evgeniy M. , Semenova Lyudmila A. , Karpina Natalia L. , Sivokozov Ilya V.
Published: April 2023

In December 2018 the patient over 60 years old sought medical help with complaints of persistent cough. Based on computed tomography data there were identified the sings (symptoms) of right lung lower lobe atelectasis. To run this patient diagnostics there were performed 6 bronchoscopies narrowed down by bronchi checks up only and described the right lung central cancer picture. At the same time the biopsy taken during one of the bronchoscopies appeared non informative. Fine needle biopsy of mediastinal lymph nodes and bronchial wall was performed twice: at Tomsk Cancer Research Institute (it was suspected B-cell lymphoma based on biopsy examination) and at The Loginov Moscow Clinical Scientific Center (signs of inflammation based on biopsy examination). The video-assisted thoracoscopy with lymph node dissection of the right lung root was performed in January 2020. As a surgical material analysis result reactive adenopathy was determined. Therefore, during more than 1 year of diagnostic research the genesis of right lung lower lobe atelectasis was not established. The patient was directed to Central Tuberculosis Research Institute for diagnosis verification. Based on clinical and radiological picture Central Tuberculosis Research Institute colleagues suspected a foreign body in the intermediate bronchus. During an endoscopic examination it was revealed stenosis, biopsies were performed, but the foreign body could not be identified. In the pathomorphological laboratory of Central Tuberculosis Research Institute there were conducted histological examination of the material after endobronchial cryobiopsy and rigid needle biopsy. Both gave an unexpected result: invasive mycosis of the bronchial wall. As a conclusion the decision was taken to apply antimycotic therapy on an outpatient basis. As a result, clear clinical and radiological positive dynamics was obtained. In these favorable conditions for endoscopic examination, it was performed vitally essential cryoextraction of foreign body. The foreign body turned out to be a fragment of a spongy bone of a centimeter size. These actions have let to unlock the right lung lower lobe.
Interstitial pneumonia with autoimmune features: monocentric prospective study
Authors: Akulkina Larisa A. , Shchepalina Anastasia A. , Moiseev Alexey S. , Brovko Mikhail Yu. , Sholomova Victoria I. , Moiseev Sergey V.
Published: April 2023

Aim. To study demographic, clinical, serological and morphological features of interstitial pneumonia with autoimmune features (IPAF), compare survival in IPAF and interstitial lung disease in connective tissue diseases (CTD-ILD), and identify predictors of mortality and transformation to CTD in the IPAF group.
Materials and methods. The IPAF group included 48 patients (75.0% women, median age 57.5 years), CTD-ILD 49 patients (79.6% women, median age 60.0 years). The analysis of demographic, clinical, laboratory and instrumental data was performed, as well as comparison of survival with the KaplanMeier method and the log-rank test in the IPAF and CTD-ILD groups. In the IPAF group, predictors of mortality and the development of CTD were studied with multivariate regression analysis.
Results. Duration of observation period did not differ significantly in the IPAF and CTD-ILD groups (40.0 and 37.0 months, respectively). Clinical criteria of IPAF were observed in 25 (52.1%) patients, serological in 44 (91.7%), morphological in 44 (91.7%). Mortality in the IPAF group was significantly higher than in the CTD-ILD group (29.2 and 6.1%, respectively; p=0.023). The presence of diabetes mellitus, CT-pattern of usual interstitial pneumonia, and an initial low forced vital capacity value were independent predictors of mortality in the IPAF group. During the observation period, the development of CTD was noted in 4 (8.3%) patients with IPAF. The independent predictor of the CTD development was the increased C-reactive protein level.
Conclusion. IPAF is characterized by a lower survival rate compared to CTD-ILD, and a relatively low risk of CTD transformation.
Efficacy and safety of patients immunization with chronic obstructive pulmonary disease with monoclonal antibodies
Authors: Antonov Vladimir N. , Ignatova Galina L.
Published: April 2023

Background. Chronic obstructive pulmonary disease (COPD) is characterized by a high level of morbidity and mortality and is associated with significant social and economic damage to the health system and society. COPD and COVID-19 have many potentially negative relationships that can lead to worse outcomes of COVID-19, including impaired lung function, old age and the presence of concomitant diseases
Aim. To assess efficacy and safety of the drug Tixagevimab + Cilgavimab for the pre-contact prevention of COVID-19 infection in patients with COPD.
Material and methods. A total of 324 male patients were included in the study, who were treated or monitored at the Regional Clinic Hospital №3 and the Regional Pulmonological Center of Chelyabinsk in AprilMay 2022. The main endpoints of observation, for 3 and 6 months, to assess the effectiveness were the dynamics of shortness of breath according to The Modified Medical Research Council Dyspnea Scale mMRC, the The forced expiratory volume in 1 second, the number of exacerbations, emergency calls, hospitalizations, polymerase chain reaction for SARS-CoV-2. Local and general reactions after immunization were evaluated. The drug Evusheld (150 mg Tixsagevimab +150 mg Cilgavimab, AstraZeneca) was used for immunization.
Results and conclusion. The effectiveness of pre-contact prevention of COVID-19 was 88.8%. The administration of the drug does not provoke an exacerbation of the underlying disease. The main clinical and functional indicators have positive dynamics by the 6th month of follow-up. The drug is well tolerated and has no significant both early and late complications.
Genetic aspects of type 1 glucagon peptide agonists clinical efficacy: A review
Authors: Golovina Evgenya L. , Grishkevich Ivan R. , Vaizova Olga E. , Samoilova Iuliia G. , Podchinenova Darja V. , Matveeva Mariia V. , Kudlay Dmitry A.
Published: April 2023

A review of publications devoted to the analysis of genetic polymorphisms of the gene encoding the glucagon-like peptide type 1 receptor and some other genes directly and indirectly involved in the implementation of its physiological action is presented. The aim of the study: to search for information on genes polymorphism that can affect the effectiveness of glucagon-like peptide type 1 agonists. The review was carried out in accordance with the PRISMA 2020 recommendations, the search for publications was based on PubMed databases (including Medline), Web of Science, as well as Russian scientific electronic source eLIBRARY.RU from 1993 to 2022. The several genes polymorphisms (GLP1R, TCF7L2, CNR1, SORCS1, WFS1, PPARD, CTRB1/2) that may affect the course and therapy of type 2 diabetes mellitus, metabolic syndrome and obesity, was described. Single nucleotide substitutions in some regions of these genes can both decrease and increase the clinical efficacy of the treatment of diabetes mellitus and metabolic syndrome with the help of type 1 glucagon-like peptide agonists: exenatide, liraglutide. Data on the role of genetic variations in the structure of the products of these genes in the effectiveness of other type 1 glucacone-like peptide agonists have not been found.
Assessment of inhalation technique in patients with bronchial asthma and chronic obstructive pulmonary disease
Authors: Trushenko Natalia V. , Stoliarevich Anna A. , Andriukov Boris G. , Nuralieva Galiya S. , Tsareva Natalya A. , Lavginova Baina B. , Avdeev Sergey N.
Published: April 2023

Abstract
Aim. Investigate inhalation techniques using different inhalers types and their effect on the course of disease.
Materials and methods. This cross-sectional study included 110 patients with asthma, chronic obstructive pulmonary disease using the inhaler at least one month. Inhaler errors performed during demonstration were evaluated for each patient and entered in the check-lists. We also collected information about co-morbidities, education, mMRC dyspnea score, rate of exacerbations, and performed spirometry.
Results. 80.9% of patients used metered-dose inhaler, 20.9% single-dose and 21.8% multiple-dose dry powder inhaler, 22.7% soft-mist inhaler. Inhaler errors were made by 80.9% patients. The mean number of mistakes in metered-dose inhaler use was 21.6, single-dose powder inhaler 1.51.3, multiple-dose dry powder inhaler 1.251.4, soft-mist inhaler 0.680.7 (р=0.003). Age, diagnosis, duration of disease, education level, inhalers usage by relatives have no influence on the inhalation technique. A number of errors was related to female gender (р=0.007) and usage of more than 2 inhalers (r=0.3, p=0.002), previous instruction about inhalation technique (r=0.3, p=0.001). On the other hand, there were correlations between the number of errors and degree of bronchial obstruction, asthma control, severity of dyspnea by mMRC score, exacerbation rate.
Conclusion. Patients with bronchoobstructive diseases perform many inhaler errors, that substantially influences the severity and course of asthma and chronic obstructive pulmonary disease.
Finerenone cardiorenal effects and its placement in treatment of chronic kidney disease in patients with type 2 diabetes mellitus: A review
Authors: Salukhov Vladimir V. , Shamkhalova Minara S. , Duganova Alla V.
Published: April 2023

Chronic kidney disease (CKD) is one of the most common complications of diabetes mellitus and an independent risk factor for cardiovascular disease. Despite guideline-directed therapy of CKD in patients with type 2 diabetes, the risk of renal failure and cardiovascular events still remains high. To date, current medications for CKD havent reduced enough the residual risk associated with inflammation and fibrosis in patients with type 2 diabetes. Here, in this review we present the results of FIDELIO-DKD, FIGARO-DKD trials and their pooled analysis FIDELITY, aimed to evaluate the effectiveness and safety of selective non-steroidal mineralocorticoid receptor antagonist finerenone in patients with type 2 diabetes with wide range stages of CKD. Modern pathophysiological aspects of mineralocorticoid receptor hyperactivation and features of their blockade by steroidal and nonsteroidal mineralocorticoid receptor antagonists are considered, differences in pharmacological effects between them are also discussed, finerenone benefits and its adverse events, demonstrated in randomized clinical trials are considered here. The probable mechanisms of early and delayed action of finerenone, which were realized in beneficial cardiovascular and renal outcomes in patients with type 2 diabetes with CKD, are presented here. Practical points for finerenone initiation and titration are indicated, aimed to minimize the hyperkalemia risk. Current guidelines for CKD treatment in patients with type 2 diabetes are analyzed, the finerenone placement in combined nephroprotective therapy is determined.
Influence of the levels of thyroid hormones on the result of radiofrequency ablation for atrial fibrillation: literature review
Authors: Bogun Nataliia , Brynza Mariia
Published: April 2023

Introduction. Atrial fibrillation is one of the most common, clinically significant cardiac arrhythmias and is associated with an increased risk of mortality, hospitalization, and deterioration in the quality of life. The prevalence of atrial fibrillation averages 1% and tends to increase with age. It is well known that aberrations of thyroid hormones have a proarrhythmogenic effect and increase the risk of cardiovascular disease. Currently, radiofrequency ablation is actively used to treat atrial fibrillation, which in most cases has high efficiency and lasting effect. However, recurrence of atrial fibrillation may occur in some patients even after radiofrequency ablation. It is known that thyroid function is closely related to the success of radiofrequency ablation and risk of relapse of atrial fibrillation after the procedure. The aim of this literature review is to determine what is already known about the effect of thyroid and thyroid-stimulating hormones levels on the outcome of radiofrequency ablation of atrial fibrillation and to analyze previous studies. Materials and methods. A complete review of the literature on atrial fibrillation and the relationship between thyroid and thyroid hormones and recurrence of atrial fibrillation after radiofrequency ablation was conducted to examine the effect of hormone levels on the success of radiofrequency ablation and recurrence of atrial fibrillation after the procedure. Results. Data from a significant number of studies suggest that the incidence of atrial fibrillation recurrence remains high after radiofrequency ablation and that thyroid hormones affect the success of radiofrequency ablation even within normal ranges. Evidence may also suggest that patients with thyroid dysfunction, even in the presence of subclinical forms, may require better monitoring of thyroid function prior to the procedure, which may reduce the incidence of atrial fibrillation recurrence. Conclusions. It should be noted that the assessment and correction of all modifying risk factors before radiofrequency ablation can prevent recurrence of supraventricular paroxysmal arrhythmias, improve the prognosis and overall quality of life in patients in this group.
List of peer reviewers for this issue
Authors: Higgins Joanna
Published: April 2023

List of peer reviewers for this issue
Cancel Culture - the Speech Behavior of Modern Society
Authors: Semenova O. F.
Published: April 2023

The research paradigm of 21st century linguistics links the study of discourse with the use of language as a public practice. Thesubjectof the study is linguistic features of different levels, characterizing the phenomenon of cancel culture. The new discourse practice or speech reality functions thanks to the media and the Internet in various areas of modern speech — in political and business communication, in professional and everyday life. Thepurposeof the study is to consider cancel culture as a linguistic object that reflects the speech life of modern society. Therelevanceof the study is determined by a modern request for regulation and control of speech behavior in the public sphere within the framework of constructive criticism. The article implements the followingresearch tasks: to describe the linguistic essence of the cancel culture and characterize the latter as a phenomenon characteristic of the communicative behavior of representatives of the linguocultural community. The linguisticmethodof discourse analysis is used as the main tool for analyzing texts with functioning examples of lexical units representing the cancellation action, which makes it possible to identify features of the communication and evaluation activities of speakers. As aresult, new language facts in the system of linguistic coordinates are localized and a possible vector for the study of aggressive communication in the language-environment category is determined. It allows for an expansion of the field of scientific understanding of the modern speech environment. The authorconcludesthat the cancel culture as a new discourse practice has a thematic and semiotic dominant in the form of destructive criticism. Research of new discourse practice on the identified attractors of criticism and aggressive communication is set as a research perspective.
The Language of the American Mass Media as an Instrument to Destabilize the Political Regime in Venezuela
Authors: Dronova S. Yu. , Perales Toro A. E.
Published: April 2023

Thestudy aimsto determine the role of the US media as a destabilizing factor in the contemporary domestic politics of Venezuela, especially in the context of the power crisis of 2013–2019. The study used themethodsof data analysis obtained through interviews, discourse analysis, the method of grounded theory, content analysis of selected sources (CNN, The Washington Post, The New York Times, Bloomberg) and event analysis, which made it possible to analyze the most frequently mentioned in the American media developments in the domestic politics of Venezuela for the period 2013–2019. Theresultsof the study reveal the bias of the American media and their dependence on the main US political course towards Venezuela, demonstrate the systematic creation of a negative image of Venezuela in the American media with a focus on the economic crisis and low living standards in the country, and attempts to influence US and international public opinion on the issue of recognizing the illegitimate parallel government of self-proclaimed President Juan Guaidó.The practical significanceof the work’s findings is the that they can be used in developing a strategy for information interaction between Venezuela and the United States, creating an information security system that accounts for the identified threats and strengthening the regional media of Venezuela.
Starting Point on the Roadmap of the Intercultural Communication Competence (Case of Turkish-Russian Language Pair)
Authors: Kozan O.
Published: April 2023

In spite of the widespread use of the concept of “intercultural communication competence” in theoretical and empirical studies, there are problems with the development of this competence in real-time teaching process within local contexts. This research aims to analyze the situation regarding the development of intercultural communicative competence in the learning process in the context of Turkey and to evaluate the approach used as a starting point for developing linguistic and cultural awareness among the students of the Russian language and literature department in Ankara Haci Bayram Veli University. As part of the study, the author used the methods of deductive analysis, the analysis of the current state of the problem as well as the onomasiological and contrastive analysis. The author analyses the results of testing, based on the ideas of contrastive onomasiology and presented in a learning book for the Translation Course. The results show that a comparative analysis of the reality - language interaction models based on concepts such as “situation”, “perspective” and “reframing” helps develop the awareness of the students towards the different “thought patterns”. The main conclusion of this paper is the thesis that contrastive onomasiology contributes to the development of linguistic and cultural awareness, which is the first step towards intercultural communicative competence.
Linguoculturology and the Linguistic Picture of the World through the Neuropsychological Prism
Authors: Sharafieva L. M. , Tretyakova G. G.
Published: April 2023

The authors consider linguoculturology through the science of neuropsychology. They define and clarify the concepts necessary for the review of linguoculturology and the linguistic picture of the world through neuroscience, which can reveal the impact of culture and language on human consciousness. The problem is that the research on unconscious processes is not sufficiently widely disclosed and remains little studied. The goal is to identify the relationship between language and cultural concepts that most effectively affect the human subconscious. The tasks are to determine the relationship between culture and language through the neuropsychological prism of response triggers; to consider the manifestation of culture, which is reflected in the language, in unconscious - psychic suggestion; to establish the interdependence of national-specific features of the genesis of the linguistic worldview through ambivalent concepts. The relevance lies in the growing attention of the international community on the correlation of truth and “fake”, acceptance and rejection, as well as a broad interest in the field of neuropsychology. The methodology of this work is a descriptive review of EEG (electroencephalogram), MRI (magnetic resonance imaging), and sound recording devices. The main conclusions. Human triggers (triggers) are inseparable from culture, language, and communication methods that lead to a narrowed perception of one’s own response. The manifestation of culture is reflected in the language, influences the people’s perceptions and their beliefs, where suggestion affects human consciousness.
Синтез и инфракрасная спектроскопия высокоэнтропийной керамики со структурой магнетоплюмбита
Authors: Винник Д.А. , Живулин В.Е. , Зыкова А.Р. , Шерстюк Д. , Пунда А.Ю. , Таскаев С.В. , Гурченко А.А. , Жукова Е.С. , Алябьева Л.Н. , Горшунов Б.П. , Гудкова С.А. , Салахитдинова М.К. , Созыкин С.А. , Вяткин Г.П.
Published: April 2023

Методом твердофазного синтеза получены ВЭО BaFe12-x(Ti,Mn,In,Ga)xO19(x=1, x=7). Исследована корреляция химического состава (степень замещения Fe), структурных параметров, магнитных характеристик. Магнитные характеристики ВЭО BaFe12-x(Ti,Mn,In,Ga)xO19 (x=1, x=7) были исследованы в широком диапазоне полей и температур. Измерены инфракрасные спектры коэффициента отражения образцов BaFe12-x(Ti,Mn,In,Ga)xO19 (x=1, x=7), содержащие особенности, связанные с фононными колебаниями. Выполнен качественный анализ зависимости характеристик фононных линий от концентрации x, а также сравнение спектров со спектрами монокристаллического образца состава BaFe12O19.
СИНТЕЗ НОВЫХ МАЛОНАТОВ МЕДИ(II) И ЖЕЛЕЗА(III) С КАТИОНАМИ БАРИЯ
Authors: Гоголева Н.В. , Блинов Д.O. , Новикова У.В. , Зорина-Тихонова Е.Н. , Нелюбина Ю.В. , Воронина Ю.К. , Кискин М.А. , Сидоров А.А. , Ерёменко И.Л.
Published: April 2023

Впервые синтезированы координационные полимеры бария-меди(II) и бария-железа(III) с дианионами малоновой кислоты [BaCuII(Mal)2(H2O)4]n (1) (CCDC № 2239603) и {[Ba2FeIII2 (OH)2(Mal)4(H2O)6]∙4H2O}n (2) (CCDC № 2239902). Комплексы построены на основе бисхелатных фрагментов 3d-металлов {M(Mal)2}х- (x = 2 для 1, x = 1 для 2), образующих в кристалле слои в 1 или связанные попарно ОН-мостиками фрагменты в 2. Атомы бария координируют атомы О хелатно-мостиковых малонат-анионов и мостиковых молекул воды, которые дополнительно связаны с фрагментами {M(Mal)2}х- в 1 и 2 за счет водородных связей, формируя таким образом сложные мостики Ba–O–H…{M(Mal)2}, пригодные для формирования 3D- и 2D-полимеров, соответственно. Новые соединения охарактеризованы по данным монокристального РСА, ИК-спектроскопии, CHN-анализа и РФА.
THEORETICAL STUDY OF NEW CANDIDATE ORGANIC MATERIALS FOR PHOTOVOLTAIC APPLICATIONS
Authors: El Karkri Anass , El Mhamedi Imane , El Malki Zakaria , Bouachrine Mohammed
Published: April 2023

Our work consists of a theoretical prediction, through DFT and TD-DFT methods, of the electronic and optical properties of six conjugated organic compounds used as electron donor materials in BHJ solar cells, of which PCBM is the acceptor material. This study is necessary to discuss the effect of substituents (donor units) on the different properties of these compounds, and to predict promising materials in organic solar cells using the AMPS-1D simulation software. The results obtained show that all the molecules have good geometric, electronic and optical properties, thus showing an increase in the power conversion efficiency of photovoltaic cells based on these materials, which reaches a value of 17% for the molecule P-Eth-TEdotT-A.
Work Outcome Preferences of Muslim and Jewish Managers in Israel: Analyzing the Differences According to the Individualism-collectivism Model
Authors: Sharabi Moshe , Shdema Ilan , Abboud-Armaly Oriana
Published: April 2023

While there is an increasing number of Muslim managers in Western countries, to the best of our knowledge no study has compared their work values to those of managers of other religions. The present study compares work outcome preferences (WOPs) of Muslim and Jewish managers in Israel, a Western country where Muslims constitute a substantial but marginalized minority. The methodology involves questionnaires administrated to 100 Muslim and 253 Jewish managers. The findings indicate significant differences between Muslim and Jewish managers across all work outcome preferences examined. While both groups view income as the most important value, Muslims have emphasized, in addition, serving society and status and prestige, whereas among Jews interest and satisfaction and interpersonal connections are more highly valued. The value differences between the two ethnoreligious groups can be explained mainly by cultural differences – individualism vs. collectivism. Implications are discussed in the context of labor market integration of minorities.
Case Study
Authors: Nanlohy Frensya M. , Monica Monica
Published: April 2023

This study is a case study research, it aims to find out how British Parliamentary debate system enhance critical thinking skills of the debaters from English Debate Club (EDC) of Pattimura University. This also leads to the extend identification and analysis of critical thinking level from EDC Debaters. The subjects are debaters from EDC who have been train educing British Parliamentary Debate System. The data was collected through In-depth interview, documents review, and audio visual materials. The result in dicates two major things that affected critical thinking from BP system, including case buildi and four teams mechanism encapsulated the effectto create platform for critical engagement in global issues to the extend analysis. As an annex, debaters can proceed to 5th level of critical thinking (Evaluation) which in dicate the 5th stages of critical thinking (Advance Thinker). Therefore, the mechanism of BP canal so be implemented in learning and teaching process, especially in critical thinking aspect.
An Analysis on Code Switching in "Dealova" Novel
Authors: PSDKU JMMatai , Metriani Luisi Amilia
Published: April 2023

Language means communication with other, where we need to build the relation to get the better understanding. It is used by people to give a message and information where everyone speaks, or identifies with one language. Beside that it is always develops every era according to the communication model used in writing or speaking. This research is aimed to give some contribution to the readers and to enrich the readerâ€™s knowledge about code switching. Therefore, the writer hopes that it will be useful for English students especially those who are studying sociolinguistics. Moreover, code switching have some types to applying in every situational based on the type of the type of codeswitching.to give different sense especially for teenager. The code switching can stimulate the reader to interest read a book, a novel, a newspaper and gives a good influence in order to improve the vocabulary in English.