bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Disparities and Inequities in the Utilization of Proton Therapy for Prostate Cancer
Authors: Washington Cyrus Gavin , Deville Curtiland
Published: November 2024

Our study sought to review and summarize the reported health disparities and inequities in the utilization of proton beam therapy (PBT) for prostate cancer. We queried the PubMed search engine through 12/2023 for original publications examining disparate utilization of PBT for prostate cancer. The query terms included the following: prostate cancer AND proton AND (disparities OR IMRT OR race OR insurance OR socioeconomic OR inequities)”. Studies were included if they involved United States patients, examined PBT in prostate cancer, and addressed health inequities. From this query, 22 studies met the inclusion criteria, comprising 13 population-based analyses, 5 single-institutional analyses, 3 cost/modeling investigations, and 1 survey-based study. The analyses revealed that in addition to age-related and insurance-related disparities, race and socioeconomic status played significant roles in the receipt of PBT. The likelihood of receiving PBT was lower for non-White patients in population-based and single-institution analyses. Socioeconomic metrics, such as higher median income and higher education level, portended an increased likelihood of receiving PBT. Conclusively, substantial age-based, racial, socioeconomic/insurance-related, and facility-associated disparities and inequities existed for PBT utilization in prostate cancer. The identification of these disparities provides a framework to better address these as the utility of PBT continues to expand across the US and globally.
SnO2 Quantum Dot-Decorated g-C3N4 Ultrathin Nanosheets: A Dual-Function Photocatalyst for Pollutant Degradation and Hydrogen Evolution
Authors: Vattikuti Surya Veerendra Prabhakar , Sudhani Hemanth P. K. , Habila Mohamed A. , Rosaiah P. , Shim Jaesool
Published: November 2024

The development of advanced functional composite materials for degrading industrial pollutants and achieving photocatalytic hydrogen (H2) production using abundant solar energy is pivotal in new and renewable energy research. This study presents the synthesis of a nanostructure comprising SnO2 quantum dots (QDs) randomly dispersed on the surface of graphitic carbon nitride (C3N4) nanosheets (Sn-C3N4), achieved through the thermal decomposition of melamine and a tin precursor. The synthesized materials were extensively characterized using various analytical techniques, with HRTEM analysis confirming the strong interaction between SnO2 QDs and C3N4. The influence of SnO2 QDs on the nanocomposite’s photocatalytic performance was evaluated, particularly regarding H2 production and the degradation of crystal violet (CV) dye under simulated solar-light irradiation. The SnO2-loaded C3N4 nanostructure exhibited a marked enhancement in photocatalytic activity, attributed to the synergistic effects of the quantum-sized SnO2 nanoparticles. The optimized photocatalyst, 3-Sn-C3N4, demonstrated superior photocatalytic efficiency, achieving 95% degradation of CV dye within 45 min under simulated sunlight, significantly outperforming bare C3N4. Furthermore, the 3-Sn-C3N4 nanostructure attained the highest H2 yield of 1305.4 μmol/h/g, a 4.6-fold increase compared with bare C3N4 (281 μmol/h/g). Enhanced photocatalytic performance was corroborated by photocurrent and EIS studies, which highlighted reduced charge carrier recombination as a critical factor in the improved activity. The underlying photocatalytic mechanisms were also examined.
Rainfall Projections for the Brazilian Legal Amazon: An Artificial Neural Networks First Approach
Authors: Monteiro Luiz Augusto Ferreira , do Nascimento Francisco Ivam Castro , de Oliveira-Júnior José Francisco , Nunes Dorisvalder Dias , Mendes David , de Gois Givanildo , Sanches Fabio de Oliveira , Wollmann Cassio Arthur , Watanabe Michel , Gobo João Paulo Assis
Published: November 2024

Rainfall in the Brazilian Legal Amazon (BLA) is vital for climate and water resource management. This research uses spatial downscaling and validated rainfall data from the National Water and Sanitation Agency (ANA) to ensure accurate rain projections with artificial intelligence. To make an initial approach, Recurrent Neural Networks (RNNs) with Long Short-Term Memory (LSTM) were employed to forecast rainfall from 2012 to 2020. The RNN model showed strong alignment with the observed patterns, accurately predicting rainfall seasonality. However, median comparisons revealed fair approximations with discrepancies. The Root Mean Square Error (RMSE) ranged from 6.7 mm to 11.2 mm, and the coefficient of determination (R2) was low in some series. Extensive analyses showed a low Wilmott agreement and high Mean Absolute Percentage Error (MAPE), highlighting limitations in projecting anomalies and days without rain. Despite challenges, this study lays a foundation for future advancements in climate modeling and water resource management in the BLA.
Detection of Fake Instagram Accounts via Machine Learning Techniques
Authors: Chelas Stefanos , Routis George , Roussaki Ioanna
Published: November 2024

This paper focuses on the detection of fake accounts on Instagram and proposes a novel solution that aims to address this problem. More specifically, a machine learning-based solution is introduced that can be employed by Instagram-based applications to combat this phenomenon. To accomplish this, publicly available data from Instagram users are collected and processed. After making the necessary feature additions to and removals from these data, they are fed into machine learning algorithms with the aim of detecting fake Instagram accounts. The interest of the results presented in this study lies in their comparability with the results of other similar studies, with the difference that fewer input features have been used. This addresses significant research challenges regarding the performance of and confidence in obtained results in this specific problem domain.
The C/C Genotype of rs1231760 in RGS2 Is a Risk Factor for the Progression of H. pylori-Positive Atrophic Gastritis by Increasing RGS2 Expression
Authors: Yamaguchi Naoyuki , Sakaguchi Takuki , Wei Jing-Jing , Tazoe Yuna , Inamine Tatsuo , Fukuda Daisuke , Ohnita Ken , Hirayama Tatsuro , Isomoto Hajime , Matsushima Kayoko , Tsukamoto Kazuhiro
Published: November 2024

Background: Chronic gastritis caused by Helicobacter pylori (H. pylori) infection can progress to gastric cancer through atrophic gastritis (AG). The risk of gastric cancer increases with the progression of AG. Therefore, investigating the risk factors for the progression of AG is important. Methods: Using the GTEx and GEO databases, we extracted thirty-four candidate genes involved in the progression of AG. Then, with in silico analysis using HaploReg v4.1 and JASPAR (Matrix ID: MA0113.3), we extracted rs1231760 of RGS2 as a key single-nucleotide polymorphism (SNP) that could be involved in the functional change in the candidate gene. A correlation analysis between the selected SNP and AG in 200 H. pylori-positive and 302 H. pylori-negative participants was conducted. For functional analysis of the SNP, a dual-luciferase assay using reporter plasmids with a major or minor allele sequence was carried out. Results: The frequency of the C/C genotype of rs1231760 was higher in the AG group than in the non-AG group (p = 0.0471). Functional analysis showed that the transcriptional activities were higher at the dexamethasone-stimulating C allele than at the others (p < 0.05). Conclusions: The C/C genotype of rs1231760 in RGS2 could be a biomarker of high-risk H. pylori-positive AG because of an increase in RGS2 expression.
Antibiotic Prophylaxis Prior to Dental Procedures
Authors: Vidović Juras Danica , Škrinjar Ivana , Križnik Tena , Andabak Rogulj Ana , Lončar Brzak Božana , Gabrić Dragana , Granić Marko , Peroš Kristina , Šutej Ivana , Ivanišević Ana
Published: November 2024

Antibiotic prophylaxis in dentistry has been recommended for different groups of patients, such as patients with impaired immunologic function, patients at risk of developing infective endocarditis or prosthetic joint infection, patients previously exposed to high-dose irradiation of the head and neck regions, and patients receiving intravenous bisphosphonate and antiangiogenic treatment. The guidelines have been changed over the years, and the list of medical conditions requiring antibiotic prophylaxis has been shortened considerably in the context of antibiotic resistance and unnecessary antibiotic prescription.
Carbon Quantum Dots as Phosphors in LEDs: Perspectives and Limitations—A Critical Review of the Literature
Authors: Bucka Katarzyna , Socha Robert P. , Wojnicki Marek
Published: November 2024

The enduring interest in carbon quantum dots (CQDs) as photoluminescent material arises from their significant advantages over inorganic quantum dots (QDs), such as low toxicity and biocompatibility, which enables their application in bioimaging and drug delivery. This review is focused on the use of CQDs for light emitting devices (LED) technology and provides a guide on how to synthesize CQDs that emit blue, green, and red light, which is necessary to produce RGB LEDs. Consideration was given to the precursors, solvents, methods, and conditions of the processes, the excitation wavelength, the emission wavelength, and the photoluminescence quantum yield (QY). These unique, organic nanoparticles have the potential to revolutionize lighting and, above all, the electronics market due to their low cost and eco-friendliness, as well as the possibility of using various precursors, including waste.
Fungal Diversity in Fire-Affected Pine Forest Soils at the Upper Tree Line
Authors: Lazarević Jelena , Topalović Ana , Menkis Audrius
Published: November 2024

Forest fires represent a significant ecological disturbance in ecosystems that increasingly affects Pinus heldreichii H. Christ forests at the upper tree line in Montenegro, due to climate change and anthropogenic factors. Soil samples were collected from five high-altitude sites in the Kuči Mountains, including three post-fire sites (2-, 4-, and 6-years post-fire) and two unburned control sites. High-throughput sequencing and soil chemical analyses were conducted to assess fungal diversity, community composition, and soil nutrient properties. The results showed that fungal diversity was significantly higher in unburned soils compared to post-fire soils, with the most prominent changes in ectomycorrhizal fungi, which are crucial for pine regeneration. The fungal community composition differed markedly between the post-fire and unburned sites, with specific taxa such as Hygrocybe conica (Schaeff.) P. Kumm. and Solicoccozyma aeria (Saito) Yurkov dominating the post-fire environments. Despite this, the fungal richness did not significantly change over time (2-, 4-, or 6-years post-fire), suggesting the slow recovery of fungal communities in high-altitude environments. In addition to shifts in fungal biodiversity, the post-fire soils exhibited higher levels of available phosphorus, likely due to the conversion of organic phosphorus into soluble forms during combustion. However, the organic matter content remained unchanged. This study provided important insights into the long-term ecological impacts of forest fires on high-altitude P. heldreichii forests and underlined the importance of preserving unburned forest areas to maintain fungal biodiversity and support natural regeneration, as well as the potential need for active restoration strategies in fire-affected regions.
Aroma Identification and Traceability of the Core Sub-Producing Area in the Helan Mountain Eastern Foothills Using Two-Dimensional Gas Chromatography and Time-of-Flight Mass Spectrometry and Chemometrics
Authors: Zhang Yuanke , Cui Zefang , Li Jianing , Wei Mengyuan , Wang Yue , Jiang Wenguang , Fang Yulin , Sun Xiangyu , Ge Qian
Published: November 2024

The combination of volatile compounds endows wines with unique aromatic characteristics and is closely related to their geographical origins. In the pursuit of origin identification and the subdivision of homogeneous production areas, clarifying the characteristics of production areas is of great significance for improving wine quality and commercial value. In this study, GC×GC-TOFMS technology was used to analyze the aroma characteristics of “Cabernet Sauvignon” wines from 26 wineries in the Helan (HL), Yinchuan (YC), Yongning (YN), Qingtongxia (QTX), and Hongsibu (HSP) sub-producing areas in the eastern foothills of Helan Mountain in Ningxia, China. The results indicate a gradual increase in relative humidity from the southern part of Ningxia, with the YN sub-region showing optimal fruit development and the QTX region having the highest maturity. A total of 184 volatile compounds were identified, with 36 compounds with an OAV > 1, crucial for the aroma profiles of primarily fermentation-derived alcohols and esters. An aromatic vector analysis revealed that “floral” and “fruity” notes are the primary characteristics of Cabernet Sauvignon wines from the Helan Mountain East region, with lower maturity aiding in the retention of these aromas. By constructing a reliable OPLS-DA model, it was determined that 15 substances (VIP > 1) played a crucial role in identifying production areas, among which phenylethyl alcohol and isoamyl alcohol were the main contributors. In addition, a Pearson correlation analysis showed a negative correlation between sunlight duration during the growing season and benzyl alcohol accumulation, while a significant positive correlation was observed during the ripening period. Due to the critical role of phenyl ethanol in identifying producing areas, this further demonstrates that sunshine conditions may be a key factor contributing to the differences in wine flavor across regions. This study offers a theoretical foundation for understanding the relationship between climatic factors and flavor characteristics, addressing the issue of wine homogenization in small production areas, clarifying typical style characteristics, and establishing a traceability technology system based on characteristic aroma.
Determining the Boundaries of Overlying Strata Collapse Above Mined-Out Panels of Zhomart Mine Using Seismic Data
Authors: Istekova Sara , Makarov Alexander , Tolybaeva Dina , Sirazhev Arman , Togizov Kuanysh
Published: November 2024

The present article is devoted to the issue of studying the patterns of displacement of superincumbent rock over panels of a mine obtained using advanced seismic technologies, allowing for the study of the boundaries of caving zones in the depths of rock mass. A seismic exploration has been performed in local areas of Zhomart mine responsible for the development of Zhaman-Aybat cuprous sandstone deposits in Central Kazakhstan at the stage of repeated mining with pulling of previously non-mined ore pillars and superincumbent rock caving. A 2D field seismic exploration has been accomplished, totaling to 8000-line m of seismic lines using seismic shot point. The survey depth varied from 455 m to 625 m. The state-of-the-art technologies of kinematic and dynamic analysis of wavefield have been widely used during data processing and interpretation targeted at identifying anomalies associated with the structural heterogeneity of the pays and rock mass, engaging modern algorithms and mathematical apparatuses of specialized geodata processing systems. The above effort resulted in new data regarding the location and morphology of the reflectors, characterizing geological heterogeneity of the section, zones of smooth rock displacement, and displacement of strata with significant disturbance of the rocks overlying mined-out productive pay. The potential of the application of modern 2D seismic exploration to studying an underworked zone with altered physical and mechanical properties located over an ore deposit has been assessed. The novelty and practical significance of the research lies in the determination of the boundaries of zones of displacement and superincumbent rock caving over the panels obtained using state-of-the-art technologies of seismic exploration. The deliverables may be used to improve the process of recognizing specific types of technogenic heterogeneities in the rock mass, impacting the efficiency and safety of subsurface ore mining, both for localization and mining monitoring.
Is Your War over Now? Nationalism, Nostalgia, and Japan’s Long Postwar from Gojira (1954) to Godzilla Minus One (2023)
Authors: Tsutsui William M.
Published: November 2024

This essay explores the political dynamics of the Godzilla film franchise over the past 70 years, arguing that critical and scholarly characterizations commonly oversimplify the movies’ complicated messages, which reflect the complex, often contradictory responses of Japanese filmmakers and audiences to the experiences of war, the atomic bombings, defeat, occupation, lasting subordination to the United States, and a seemingly endless postwar period. The analysis focuses on Honda Ishirō’s Gojira (1954), in which pacifist sentiments are tempered by depictions of military weaponry and patriotic pride, and Yamazaki Takashi’s Godzilla Minus One (2023), where ahistorical narratives, misty-eyed nostalgia, and ultranationalist tropes co-exist with strong anti-authoritarian and anti-establishment themes. By contextualizing these two films within the contested history of early postwar Japan and the polarized politics of the early twenty-first century, this essay suggests that the Godzilla series has shown remarkable continuities over time and has captured the profound ambivalence with which the Japanese people have negotiated memory, nationalism, and the charged relationship between Japan and the United States since the end of World War II.
Unmet Needs for Dental Care Before and During the COVID-19 Pandemic in Greece: A Cross-Sectional Study
Authors: Ntais Christos , Charalampaki Athina , Talias Michael A. , Kontodimopoulos Nikolaos , Fanourgiakis John
Published: November 2024

Background/Objectives: Unmet dental needs involve cases wherein someone needed dental care and did not receive it. Published data on unmet dental needs are limited. This cross-sectional study investigates unmet dental needs in Greece before and during the COVID-19 pandemic. Methods: For this study, a questionnaire was created and distributed to a non-random sample. It was completed by 277 individuals. The questionnaire was based on the European Union Statistics on Income and Living Conditions (EU-SILC) tool, which is used to investigate unmet health needs. It was enriched with questions about unmet dental needs before and during the COVID-19 pandemic. Results: Of the 277 participants, 23.1% reported unmet dental needs before the onset of the COVID-19 pandemic, which decreased to 13.4% after the onset of the pandemic. However, a significant proportion of the sample (48.3%) reported no need for dental care after the onset of the COVID-19 pandemic. It is also worth noting that there were instances of dental visit avoidance, both when symptoms were present and for standard check-up/follow-up purposes, at rates of 17% and 27.8%, respectively. Conclusions: Unmet dental needs occurred at lower rates after the onset of the COVID-19 pandemic than those recorded before the pandemic. The main reasons for unmet needs before the pandemic were the cost of dental services and fear of treatment procedures or the visit to the dentist, while after the onset of the COVID-19 pandemic, lack of time and fear of coronavirus transmission were added.
Personality Traits and Sociodemographic Variables’ Effects on Parental Burnout During the Second and Fourth COVID-19 Waves in Italian Parents
Authors: Giordano Giulia , Caci Barbara , Alesi Marianna , Gentile Ambra , Burgio Sofia , Polizzi Concetta
Published: November 2024

(1) Background: Since the COVID-19 pandemic was a source of stress for families, this study aimed to investigate the influence of dispositional factors, such as personality traits and sociodemographic variables, on parental burnout among Italian parents during two waves of the COVID-19 pandemic. Therefore, the study assessed personality traits and sociodemographic variables as protective or risk factors for parental burnout levels. (2) Methods: The study consisted of two cross-sectional samples collected during the second and fourth waves of the Italian pandemic. The participants included 600 Italian parents: 245 from the second wave (average age = 37.12, SD = 2.78) and 355 from the fourth wave (average age = 36.89, SD = 3.14). The measures used were the Balance between Risks and Resources, the Personality Inventory, and a sociodemographic questionnaire. (3) Results: The t-test showed that parents in the fourth wave had lower parental burnout levels. Moreover, stepwise multiple linear regression revealed that sociodemographic variables did not have an effect, while significant effects of personality traits were found. Specifically, neuroticism was identified as a risk factor for parental burnout, while agreeableness and openness were identified as protective factors. (4) Conclusions: The findings indicated that similar stress levels were reported between the two waves of parents and that personality traits play a crucial role in facilitating or limiting the management of parental competencies during a risk condition.
Upper Limb Therapy for Infants and Young Children with Unilateral Cerebral Palsy: A Clinical Framework
Authors: Greaves Susan , Hoare Brian
Published: November 2024

Early detection and rehabilitation interventions are essential to optimise motor function in infants and young children with unilateral cerebral palsy. In this paper we report a clinical framework aimed at enhancing upper limb therapy for infants and young children with unilateral cerebral palsy during a sensitive period of brain development. We describe two major therapeutic approaches based on motor learning principles and evidence: constraint-induced movement therapy and bimanual therapy. These two therapies have demonstrated efficacy in older children and emerging evidence is available for their application to infants younger than 2 years of age. To provide clinicians with guidance as to when to implement these therapies, we discuss the key consideration when undertaking upper limb therapy programs. In addition, we describe the factors to consider when choosing which approach may be suitable for an individual child and family. Detailed strategies for implementing these therapies in infants and young children of different ability levels are given.
The Role of Small-Bowel Endoscopy in the Diagnosis and Management of Small-Bowel Neuroendocrine Tumours
Authors: Bosch Elisabet Maristany , Laskaratos Faidon-Marios , Sodergren Mikael , Faiz Omar , Humphries Adam
Published: November 2024

Neuroendocrine tumours (NETs) are relatively rare neoplasms but represent one of the most frequent types of primary small-bowel tumours. Their incidence is rising, and this is most likely because of their more frequent early-stage detection, physician awareness, and increasing availability and use of imaging and small-bowel endoscopic techniques, such as video capsule endoscopy and device-assisted enteroscopy, which enable the detection, localisation, and histological sampling of previously inaccessible and underdiagnosed small-bowel lesions. This review summarises the role of small-bowel endoscopy in the diagnosis and management of small-bowel NETs to assist clinicians in their practice. Small-bowel endoscopy may play a complementary role in the diagnosis of these tumours alongside other diagnostic tests, such as biomarkers, conventional radiology, and functional imaging. In addition, small-bowel enteroscopy may play a role in the preoperative setting for the identification and marking of these tumours for surgical resection and the management of rare complications, such as small-bowel variceal bleeding, in cases of portal hypertension due to the encasement of mesenteric vessels in fibrotic small-bowel NETs.
Perifoveal Exudative Vascular Anomalous Complex (PEVAC): Retinal Vascular Density Findings
Authors: Aweidah Hamzah , Cosette Deborah , Lishinsky-Fischer Natan , Eshak Tarek B. , Batash Tomer , Chowers Itay , Jaouni Tareq , Levinger Nadav , Levy Jaime
Published: November 2024

Objectives: This study aimed to describe the clinical, optical coherence tomography (OCT) and OCT angiography (OCTA) findings and characteristics in patients with perifoveal exudative vascular anomalous complex (PEVAC) and compare the macular vascular density with the age-matched control group. Methods: We conducted a case–control study to compare demographic information, clinical observations, and OCT/OCTA findings in eyes with PEVAC (n = 5 eyes in 5 patients) and a control group of subjects matched for age (n = 9). The Advanced Retina Imaging (ARI) network algorithms were utilized to evaluate OCTA observations. Statistical analysis was performed by the nonparametric Mann–Whitney U test. Results: Patients with PEVAC had a mean (±SD) age at presentation of 70 ± 12.6 years, the mean follow-up period was 7.8 ± 5.2 months, and unilateral disease was observed. Four out of the five patients in our cohort had a history of systemically treated hypertension and dyslipidemia. Three eyes had lesions in the inner temporal retinal zone, while the remaining two eyes had lesions in the inner inferior or central zone. Retina slab analysis using OCTA showed no significant difference in vascular density parameters between the PEVAC and control groups. Conclusions: Although limited by a small sample size, our study suggests that macular vessel density shows no significant difference between PEVAC cases and control eyes.
Skin and Nail Predictors of Psoriatic Arthritis Development: A Holistic Overview Integrating Epidemiological and Physiopathological Data
Authors: Fratton Zeno , Giovannini Ivan , Zabotti Alen , Errichetti Enzo
Published: November 2024

Dermatological manifestations are considered to be of significant importance in identifying individuals with psoriasis at a higher risk of developing arthritis, as rheumatological involvement typically follows the onset of skin/nail lesions. This review summarizes the literature evidence about dermatological predictors of psoriatic arthritis (PsA) development, also analyzing the underlying physiopathological mechanisms and potential biases. Such an integration between statistical evidence and a mechanism-based approach aims to emphasize the most robust skin/nail risk factors upon which clinicians should focus most in daily clinical practice. Accordingly, psoriasis severity and nail changes due to matrix involvement would result in the most relevant risk factors for PsA occurrence, while other possible predictors (e.g., scalp and inverse psoriasis) do not seem to be supported by a significant pathogenetic link.
Monoclonal Antibody Switching in Biologic Treatment of Chronic Rhinosinusitis with Nasal Polyps
Authors: Habenbacher Michael , Moser Ulrich , Hadl Oliver , Kiss Peter , Holzmeister Clemens , Pock Jakob , Walla Katharina , Lang Angelika , Andrianakis Alexandros
Published: November 2024

Objectives: to evaluate our real-world data on the efficacy and safety of switching between two monoclonal antibodies in biologic treatment of uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Methods: All patients receiving biologic treatment for uncontrolled CRSwNP between April 2020 and March 2024 at a tertiary referral center who needed transitioning between biologic agents were retrospectively analyzed. The following parameters were investigated: patient’s clinical characteristics, wash-out periods, treatment outcome, and switching-related side effects. Results: Out of 91 CRSwNP patients who received biologic treatment, 4 patients (4.4%) necessitated switching to an alternative biologic agent. Three patients were switched to a different antibody because of insufficient symptom control with the initially prescribed biologic, while the other patient required switching to an alternative agent due to a side effect. Switching resulted in all four patients achieving a significant improvement in all outcome parameters. There were no switching-related side effects, and the switching procedure was performed in three cases without a wash-out period. Conclusion: CRSwNP patients under biologic therapy with an insufficient response or medication-related side effect may benefit from switching to an alternative biologic agent. Larger, prospective multicenter studies are warranted to further validate the effectiveness and safety of switching agents in the biologic treatment of CRSwNP.
Enhancing Building Information Modeling Effectiveness Through Coopetition and the Industrial Internet of Things
Authors: da Silva Agostinho , Marques Cardoso Antonio J.
Published: November 2024

The construction industry plays a crucial role in the global economy but faces significant challenges, including inefficiencies, high costs, and environmental impacts. Although Building Information Modeling (BIM) has been widely adopted as a solution to these issues, its practical impact remains limited. This study investigates how manufacturers can enhance their contributions to improve BIM’s effectiveness, proposing that coopetition practices—combining competition and cooperation—can positively influence these contributions, thereby enhancing the benefits of BIM. To explore this hypothesis, an Experimental Coopetition Network was implemented in the Portuguese ornamental stone (POS) sector, utilizing Industrial IoT technology to facilitate collaboration among selected companies. The study assessed the impact of coopetition practices on key performance indicators related to BIM, including on-time delivery, labor productivity, and CO2 emissions. The findings demonstrate significant improvements in scheduling, operational efficiency, and environmental sustainability, validating the hypothesis that coopetition practices can enhance manufacturers’ contributions to BIM. These results suggest that coopetition practices contribute to better project outcomes, increased competitiveness, and sustainability within the construction industry. Despite the promising results, the study acknowledges limitations such as the scope of the sample size and observation periods, indicating areas for future research. This research contributes to the theoretical framework of coopetition, aligning with the United Nations Sustainable Development Goals (SDGs), and provides valuable insights for industry practitioners and policymakers seeking to implement more sustainable construction practices.
Digital Revolution: Emerging Technologies for Enhancing Citizen Engagement in Urban and Environmental Management
Authors: Berigüete Fanny E. , Santos José S. , Rodriguez Cantalapiedra Inma
Published: November 2024

Citizen participation is key in urban planning, but traditional methods are often limited in terms of accessibility and inclusion. This study investigates how the use of emerging technologies such as Virtual and Augmented Reality (VR/AR), Digital Twin (DT), Building Information Modelling (BIM), Artificial Intelligence (AI), and Geographic Information Systems (GIS) can enhance citizen participation in urban planning. Through the review and analysis of existing literature, combined with the study of cases from cities in Eurasia and North America on the implementation of these technologies in urban and environmental planning, the results indicate that the use of multi-reality technologies facilitates immersive visualization of urban projects, allowing citizens to better understand the implications of proposed changes. Furthermore, the integration of real-time monitoring, such as forest and climate surveillance, improves environmental control. Technologies like AI and GIS also enable greater precision and empowerment in participatory decision-making. Nevertheless, the emergence of these technologies presents a challenge that must be addressed, as it is essential to establish a regulatory framework to ensure their responsible use. In conclusion, these platforms not only increase participation and co-creation but also enable more efficient, sustainable, and inclusive urban planning. Greater adoption of these technologies is suggested to optimize the urban decision-making process.
The Impact of Reinforcement Ratio on the Punching Shear of CFRP Grid-Reinforced Concrete Two-Way Slabs
Authors: Duan Ning , Zhang Jiwen
Published: November 2024

Corrosion of steel reinforcement in concrete slabs undermines structural durability and shortens the lifespan of concrete structures. Carbon Fiber-Reinforced Polymer (CFRP) is a promising material offering benefits such as high strength, corrosion resistance, and light weight. This study aims to investigate the punching shear performance of concrete slabs reinforced with CFRP grids, focusing on the effects of different reinforcement ratios. A series of experiments were conducted on two-way concrete slabs reinforced solely with CFRP grids to assess their punching shear resistance. Experimental results show that the CFRP grid achieves an ultimate tensile strength of 2181 MPa, with the cracking load of CFRP grid-reinforced slabs reaching approximately 20% of the ultimate load, highlighting a strong correlation between the ultimate load and grid reinforcement ratio. The observed punching failure exhibited clear brittle characteristics, characterized by the formation of radial and circumferential cracks on the tensile surface of the slab. The reinforcement ratio significantly influences the failure mode of the slabs; as the reinforcement ratio increases, the ultimate punching loads also increase. Additionally, a mathematical formula is proposed to predict the punching bearing capacity, achieving calculation errors below 20%. These findings contribute valuable insights into using CFRP grids as primary reinforcement, enhancing the design and application of durable concrete slab structures.
Dimensional Accuracy After Precision Milling of Magnesium Alloys Using Coated and Uncoated Cutting Tools
Authors: Korpysa Jarosław , Habrat Witold
Published: November 2024

Magnesium alloys are an important group of materials that are used in many industries, primarily due to their low weight. Constantly increasing quality requirements make it necessary to improve the accuracy of manufactured products. In this study, the precision milling process for AZ91D and AZ31B magnesium alloys was investigated, and the results obtained with uncoated and TiB2-coated end mills were compared. The impact of variable cutting parameters was also investigated. Specifically, the study focused on the dimensional accuracy of the machined parts. The results showed that even though the dimensional accuracy obtained in milling both magnesium alloys was comparable, it was higher in the case of the AZ31B alloy by up to 22%. The study also demonstrated that the use of the TiB2 coating did not have the desired effect and that higher dimensional accuracy up to 27% was obtained with the uncoated tool.
Restructuring the Basic Design of Several Accelerator-Based Concrete Mixes by Integrating Superplasticizers
Authors: Simedru Alexandru Florin , Cadar Oana , Becze Anca , Simedru Dorina
Published: November 2024

The increasing demand for infrastructure, the need to consolidate aging structures, and the effects of climate change imply the replacement or improvement of traditional concrete. This study investigates three accelerators and their mixtures (Ca(NO3)2·4H2O, Al2(SO4)3·18H2O, and Na2S2O3·5H2O) (series I) and their counterparts with superplasticizers (Dynamon SR41) (series II) as additives in standard concrete to improve its functionality. The standard concrete and new concrete mixes were analyzed using X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), and tests for water absorption, bulk density, and compressive strength. XRD analysis showed that all concrete mixes had similar structures composed of quartz, portlandite, larnite, calcium silicate, ettringite, albite, and muscovite in varying proportions. Their microstructures, as shown by SEM images, revealed the presence of ettringite, portlandite, and C-S-H gel at high magnification (1–5 kx). The addition of the superplasticizer remodeled the surface of the concrete mix, reducing the pore radius and increasing its compaction. These changes helped to reduce its bulk density while increasing the compressive strength. The results showed that all the concrete mixtures are similar to the standard concrete and can replace it for better functionality, but Na2S2O3·5H2O with superplasticizer concrete mixture had the higher compressive strength, supplying additional benefits.
Inter-Ply Slipping Behaviors and Kinetic Equation of Carbon Fiber-Reinforced Epoxy Prepregs for Hot Diaphragm Preforming
Authors: Zhang Haoxuan , Liu Jintong , Zhang Congfa , Li Hongfu , Yue Guangquan , Sun Baozhong , He Boyan
Published: November 2024

Wrinkles are urgent problems to be solved in the process of hot diaphragm preforming. Inter-ply slipping resistance is one of the causes of wrinkles. In this paper, based on the vertical inter-ply slipping test system, the inter-ply slipping behaviors of carbon fiber-reinforced epoxy resin composite prepregs were characterized. The mechanism of wrinkles caused by inter-ply slipping resistance was analyzed. According to the different characteristics expressed by the fiber and resin during the slip process, the inter-ply slipping behaviors of the prepregs were divided into three stages. The effect of temperature on the inter-ply slipping stresses was shown. The temperature will affect the viscosity of the prepregs. When the viscosity of the prepregs is low, the inter-ply slipping resistance will decrease. Based on the Coulomb friction law and the hydrodynamic equation, the inter-ply slipping kinetic equation of the prepregs was established. The inter-ply slipping kinetic equation was introduced into the ABAQUS main program by the ‘vfriction’ subroutine. The introduction of inter-ply slipping dynamics improved the accuracy of predicting the shape and position of wrinkles.
A New Slicer-Based Method to Generate Infill Inspired by Sandwich-Patterns for Reduced Material Consumption
Authors: Steck Patrick , Schuler Dominik , Witzgall Christian , Wartzack Sandro
Published: November 2024

This work presents a novel infill method for additive manufacturing, specifically designed to optimize material use and enhance stiffness in fused filament fabrication (FFF) parts through a geometry-aware, corrugated design inspired by sandwich structures. Unlike standard infill patterns, which typically employ uniform, space-filling grids that often disregard load-specific requirements, this method generates a cavity inside the component to be printed and fill the space between inner and outer contours with continuous, adaptable extrusion paths. This design enables consistent support and improved load distribution, making it particularly effective for parts under bending stresses, as it enhances structural resilience without requiring additional material. Simulations performed on a 10 cm3 test part using this method showed potential reductions in material consumption by up to 77% and a decrease in print time by 78%, while maintaining stiffness comparable to parts using conventional 100% grid infill. Additionally, simulations demonstrated that the new corrugated infill pattern provides near-isotropic stiffness, addressing the anisotropic limitations often seen in traditional infill designs that are sensitive to load orientation. This geometry-aware infill strategy thus contributes to balanced stiffness across complex geometries, enhancing reliability under mechanical loads. By integrating directly with slicer software, this approach simplifies advanced stiffness optimization without the necessity of finite element analysis-based topology optimization.
Analysis of the Radial Force of a Piezoelectric Actuator with Interdigitated Spiral Electrodes
Authors: Wang Yateng , Ren Tianxing , Ren Yuan , Gu Ruijie , Liu Yonggang
Published: November 2024

The actuator is a critical component of the micromanipulator. By utilizing the properties of expansion and contraction, the piezoelectric actuator enables the manipulator to handle and grasp miniature objects during micromanipulation. However, in piezoelectric ceramic disc actuators with conventional surface electrode configurations, the actuating force generated in the radial direction is relatively limited. When used as the actuation element of the manipulator, achieving regulation over a wide range of operating strokes becomes challenging. Therefore, altering the electrode structure is necessary to generate a greater radial force, thus enhancing the positioning and grasping capabilities of the operating arm. This paper investigates a piezoelectric actuator with interdigitated spiral electrodes, featuring a constant pitch between adjacent electrodes. The radial force was tested under mechanical clamping conditions, and the influence of the electrical signal was examined. The characteristics of the electrode structure were described, and the working principles of the piezoelectric actuators were analyzed. Theoretical equations were derived for the macroscopic characterization of the radial clamping force of the actuator, based on the piezoelectric constitutive equation, geometric principles, and Bond matrix transformation relationships. A finite element model was developed, reflecting the features of the electrode structure, and finite element simulations were employed to verify the theoretical equations for radial force. To prepare the samples, encircled interdigitated spiral electrode lines were printed on the PZT-52 piezoelectric ceramic disc using a screen printing method. The clamping force experimental platform was established, and experiments on the clamping radial force were conducted with electrical signals of varying waveforms, frequencies, and voltages. The experimental results show that the piezoelectric ceramic disc actuator with an interdigitated spiral electrode line structure, when excited by a stable sine wave operating at 200 V and 0.2 Hz, generated a peak force of 0.37 N. It was 1.76 times greater than that produced by a previously utilized piezoelectric disc with conventional electrode structures.
Sclareolide as Antifungal Strategy Against Cryptococcus neoformans: Unveiling Its Mechanisms of Action
Authors: Ganeshkumar Arumugam , Lima Patricia Michelle Nagai de , Haribabu Jebiti , Borges Bruno Montanari , Preite Nycolas Willian , Loures Flavio Vieira , Arulraj Arunachalam , Junqueira Juliana Campos
Published: November 2024

Cryptococcal infection commonly begins as an opportunistic infection in humans, however, this can escalate to a systemic or life-threatening form in immunocompromised individuals. Here, we aim to identify novel antifungal molecules from plants resources. Sclareolide, a phytochemical classified as a sesquiterpene lactone, was assessed against Cryptococcus neoformans H99. Sclareolide exhibited promising antifungal properties with a minimum inhibitory concentration (MIC) of 16 µg/mL. Additionally, the C. neoformans growth rate was significantly affected by sclareolide treatment in a concentration-dependent manner, as observed through a time killing assay, with a significant reduction at MIC × 8 compared to the control by 48 h. To elucidate the underlying mechanisms of sclareolide antifungal activity, fluorescence-based methods were employed. Propidium iodide (PI) accumulation assay indicated a reduction in C. neoformans membrane integrity, with values as low as 6.62 ± 0.18% after treatment. Moreover, sclareolide at MIC × 4 and MIC × 8 significantly increased the production of reactive oxygen species (ROS) and reduced the mitochondrial membrane potential (MMP), suggesting oxidative stress and mitochondrial dysfunction in C. neoformans. Sclareolide did not induce caspase-dependent apoptosis, suggesting a non-apoptotic mechanism. Further, a checkerboard experiment was performed to assess potential synergistic interaction with Amphotericin B, however, no synergism was observed. Moving on, sclareolide at 128 µg/mL did not exhibit toxicity in Galleria mellonella, further supporting its potential as a safe antifungal agent. These findings suggest that the antifungal activity of sclareolide against C. neoformans is mediated by oxidative stress. Further in vivo and pharmacokinetic studies are recommended to explore the potential of sclareolide as a prototype for the development of novel anti-cryptococcal therapies.
The Effects of Low Concentrations and Long-Term Contamination by Sodium Dodecyl Sulfate on the Structure and Function of Bacterial Communities in the Lake–Terrestrial Ecotone
Authors: Zeng Lingquan , Zhu Qi , Li Chunhua , Ye Chun
Published: November 2024

Due to the growing focus on daily hygiene practices, sodium dodecyl sulfate (SDS), a widely used surfactant, is increasingly found in domestic sewage and rainfall runoff. Upon entering the lake–terrestrial ecotone, SDS affects the composition, abundance, and functional capacity of soil bacterial communities due to its bacteriostatic properties. To investigate the effects of long-term discharge of sewage containing low concentrations of SDS on microorganisms in the lake–terrestrial ecotone, alterations in bacterial community structure, functional genes, and biomass were examined using a simulated continuous pollutant input. The results indicated the following: (1) The degradation rate of sodium dodecyl sulfate (SDS) by soil microorganisms in the lake–terrestrial ecotone under long-term and low concentrations of SDS stress ranged from 11 to 16 mg/kg·d. (2) The effects of low concentrations and long-term SDS stress on bacterial community structure and gene function in the lake–terrestrial ecotone differed significantly from those of short-term pollution. The damage to microbial-promoted material cycling in the lake–terrestrial ecotone was more severe; however, the proliferation of pathogenic bacteria remained continuously suppressed. (3) Soil bacteria in the lake–terrestrial ecotone responded to the stress of long-term and low concentrations of SDS primarily by enhancing chemotaxis and tolerance.
Appendicular Skeletal Muscle Mass (ASMM) and Fat-Free Mass (FFM) DXA–BIA Estimations for the Early Identification of Sarcopenia/Low Muscle Mass in Middle-Aged Women
Authors: Moroni Alessia , Gasparri Clara , Perna Simone , Rondanelli Mariangela , Micheletti Cremasco Margherita
Published: November 2024

Background/Objectives: Sarcopenia involves the loss of muscle mass along with a decrease in muscle strength and physical performance. The aim of this paper was to compare the already published BIA equations for the estimation of Appendicular Skeletal Muscle Mass (ASMM) and Fat-Free Mass (FFM) with dual X-ray densitometer DXA estimations in order to determine whether Bioelectrical Impedance Analysis (BIA) could be a feasible application on a general population for the detection of low muscle mass and sarcopenia. Methods: Seventy-nine healthy women aged 40–70 years were included. Assessments involved BIA and DXA evaluations and anthropometric measurements. Results: DXA and BIA estimations showed great agreement, particularly the ones introduced by Scafoglieri et al. (2017) for ASMM (mean difference 1.81 kg) and Kanellakis et al. (2020) equation for FFM (mean difference 0.52 kg) resulted in the best fit for the cohort in analysis. BIA could intercept a low muscle mass condition which can be linked to sarcopenia. Conclusions: This study showed how the use of BIA represents an effective and reliable method in the evaluation of sarcopenia.