bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of preoperative CT imaging shift parameters of the lateral plateau with lateral meniscal injury in Schatzker IV-C tibial plateau fractures
Authors: Liu Yulong , Fang Run , Tu Bizhi , Zhu Zheng , Zhang Chengnan , Ning Rende
Published: October 2023

Background

Schatzker IV-C is a high-energy tibial plateau fracture often accompanied by lateral meniscus injuries. While imaging examinations are routine preoperative measurements, the correlation between CT imaging shift parameters of the lateral plateau and lateral meniscal injury in Schatzker IV-C fractures remains uncovered.

Methods

This retrospective study enrolled a total of 60 patients with Schatzker IV-C tibial plateau fractures at the First People’s Hospital of Hefei. Prior to surgery, CT imaging was used to measure the numerical values of lateral plateau depression (LPD) and lateral plateau widening (LPW). The degree of lateral meniscus injury was confirmed based on intraoperative direct vision, with patients being classified into meniscus injury and non-meniscus injury groups. Dichotomous logistic regression was employed to evaluate the correlation between LPD, LPW, and lateral meniscus injury, while the optimal cut-off points for predicting lateral meniscal injury with LPD and LPW were determined using receiver operator characteristic (ROC) curves.

Results

The meniscus injury group exhibited a mean LPD of 15.3 ± 3.5 mm, which was significantly higher than the non-meniscus injury group’s mean LPD of 8.4 ± 3.4 mm (P < 0.05). Similarly, the meniscus injury group had a larger mean LPW of 9.4 ± 1.8 mm compared to the non-meniscus injury group’s mean LPW of 6.9 ± 0.9 mm (P < 0.05). The optimal cut-off points for predicting lateral meniscal injury were determined to be 8.40 mm for LPD (with a sensitivity of 95%, specificity of 85%, and AUC of 0.898) and 7.90 mm for LPW (with a sensitivity of 75%, specificity of 90%, and AUC of 0.897).

Conclusions

Patients with Schatzker IV-C tibial plateau fractures are at a significantly higher risk of lateral meniscal injury when the LPD exceeds 8.40 mm and/or the LPW exceeds 7.90 mm. Our results may provide novel reference metrics for the early diagnosis of lateral meniscal injury in Schatzker IV-C tibial plateau fracture patients when the MRI examination is not available.
Mobile health supported multi-domain recovery trajectories after major arthroplasty or spine surgery: a pilot feasibility and usability study
Authors: Naik Bhiken I. , Durieux Marcel E. , Dillingham Rebecca , Waldman Ava Lena , Holstege Margaret , Arbab Zunaira , Tsang Siny , Cui Quanjun , Li Xudong Joshua , Singla Anuj , Yen Chun-Po , Dunn Lauren K.
Published: October 2023

Background

Recovery after surgery intersects physical, psychological, and social domains. In this study we aim to assess the feasibility and usability of a mobile health application called PositiveTrends to track recovery in these domains amongst participants undergoing hip, knee arthroplasty or spine surgery. Our secondary aim was to generate procedure-specific, recovery trajectories within the pain and medication, psycho-social and patient-reported outcomes domain.

Methods

Prospective, observational study in participants greater than eighteen years of age. Data was collected prior to and up to one hundred and eighty days after completion of surgery within the three domains using PositiveTrends. Feasibility was assessed using participant response rates from the PositiveTrends app. Usability was assessed quantitatively using the System Usability Scale. Heat maps and effect plots were used to visualize multi-domain recovery trajectories. Generalized linear mixed effects models were used to estimate the change in the outcomes over time.

Results

Forty-two participants were enrolled over a four-month recruitment period. Proportion of app responses was highest for participants who underwent spine surgery (median = 78, range = 36–100), followed by those who underwent knee arthroplasty (median = 72, range = 12–100), and hip arthroplasty (median = 62, range = 12–98). System Usability Scale mean score was 82 ± 16 at 180 days postoperatively. Function improved by 8 and 6.4 points per month after hip and knee arthroplasty, respectively. In spine participants, the Oswestry Disability Index decreased by 1.4 points per month. Mood improved in all three cohorts, however stress levels remained elevated in spine participants. Pain decreased by 0.16 (95% Confidence Interval: 0.13–0.20, p < 0.001), 0.25 (95% CI: 0.21–0.28, p < 0.001) and 0.14 (95% CI: 0.12–0.15, p < 0.001) points per month in hip, knee, and spine cohorts respectively. There was a 10.9-to-40.3-fold increase in the probability of using no medication for each month postoperatively.

Conclusions

In this study, we demonstrate the feasibility and usability of PositiveTrends, which can map and track multi-domain recovery trajectories after major arthroplasty or spine surgery.
Impact of oral diseases on 12- and 15-year-old children’s quality of life: condition-specific oral health related quality of life analysis
Authors: Kaewkamnerdpong Issarapong , Urwannachotima Nipaporn , Prasertsom Piyada , Charoenruk Nuttirudee , Krisdapong Sudaduang
Published: October 2023

Background

Oral diseases can affect children’s quality of life. The aim of the present study was to assess the Condition-Specific (CS) impacts from oral diseases in 12- and 15-year-old Thai population using data from the two consecutive national oral health-related quality of life surveys.

Methods

The oral health–related quality of life surveys were conducted for this study as a part of 6th and 7th national oral health survey. The study sample of 1,066 12- and 815 15-year-olds from 6th national oral health survey; and 556 12- and 351 15-year-olds from 7th national oral health survey were from Bangkok and four regions of Thailand. Oral impacts were assessed by the Child-Oral Impacts on Daily Performances index for 12- and Oral Impacts on Daily Performances index for 15-year-olds. The overall impacts and CS impacts attributed to oral diseases were calculated. The detailed characteristics of the CS impacts were analyzed. Cochran’s Q test and McNemar’s test were used to determine the difference between the proportions of CS impacts of caries, gingival diseases, oral lesions, and malocclusion.

Results

CS impacts-caries were prevalent for both age, followed by gingival disease and oral lesions. CS impacts-caries were the highest in the intensity and extent for both age groups. CS impacts-caries were significantly higher than those of gingival diseases for eating, speaking, relaxing, emotional state, and studying. CS impacts-gingival disease was significantly higher than caries for cleaning in one survey.

Conclusions

CS impacts-caries were the most prevalent and severe among adolescent. Gingival disease was infrequently related to severe impacts on daily performances.
Exploring the training of chinese medical staff oriented to the need for clinical drug information services: from the perspective of drug information patients obtained and need
Authors: Huang Rong , Huang Yuankai , Liu Jiayuan , Chen Lei
Published: October 2023

Background

There are some gaps between the training of drug information service competencies for medical staff and drug information patients need in China.

Objective

To investigate drug information patients obtained and need for further providing directions for the training of drug information service competencies among medical staff in China from patients’ perspectives.

Methods

A face-to-face nationwide survey was conducted using a stratified sampling method. Data were analyzed descriptively using frequencies, percentages and mean. Several subgroup analyses using Chi-square tests were conducted to identify patients’ need for drug information in China.

Results

A total of 1994 questionnaires from medical institutions in China were returned. Most of the drug information obtained by patients came from physicians, and different types of drug information were important to patients. Additionally, patients had different needs for drug information due to age, gender, diagnosis and treatment status, and education level.

Conclusions

The training of medical staff needs to increase the presence of nurses and pharmacists in drug information services, enhance the awareness of “patient-centered” services, and improve the ability to provide information services specific to the characteristics of patients.
The mediating role of organizational commitment between workplace bullying and turnover intention among clinical nurses in China: a cross-sectional study
Authors: Xia Guili , Zhang Yi , Dong Ling , Huang Fengtao , Pu Yao , Luo Jiang , Chen Yi-ping , Lei Zhengxia
Published: October 2023

Background

Workplace bullying experienced by clinical nurses is a critical and pervasive issue that not only detrimentally impacts nurses but also poses a significant threat to the overall quality of nursing services and patient care. This study aimed to determine the mediating role of organizational commitment in the relationship between workplace bullying and turnover intention among clinical nurses in China.

Methods

Participants were recruited from 40 hospitals in various provinces of China from December 2, 2021 to February 25, 2023, using convenience sampling. After obtaining hospital ethical approval and participants’ informed consent, clinical nurses (n = 585) from different nursing departments in different hospitals completed the questionnaire. The Socio-demographic Questionnaire, Negative Acts Qestionnaire, Chinese Workers’ Organizational Commitment Scale and Turnover Intention Questionnaire were used to collect general demographic data of nurses and assess workplace bullying they experienced, their level of organizational commitment and turnover intention. Descriptive statistics, Pearson correlation analyses and structural equation model were adopted to analyze the data.

Results

Pearson’s correlation analysis showed that that workplace bullying was significantly negatively correlated with organizational commitment (r = − 0.512, P<0.01) and significantly positively correlated with turnover intention (r = 0.558, P<0.01), organizational commitment was significantly negatively correlated with turnover intention (r = − 0.539, P<0.01). Mediation analysis indicated organizational commitment partially mediated the association between workplace bullying and turnover intention. The total effect (β = 0.69) of workplace bullying on turnover intention consisted of its direct effect (β = 0.41) and the indirect effect mediated through organizational commitment (β = 0.280), with the mediating effect accounting for 40.58% of the total effect.

Conclusion

Organizational commitment mediated the associations of workplace bullying and turnover intention. Therefore, healthcare organizations and nursing managers should develop appropriate strategies to enhance nurses’ organizational commitment in order to reduce their turnover intention.
Preparation of Escherichia coli ghost of anchoring bovine Pasteurella multocida OmpH and its immunoprotective effect
Authors: Chen Nannan , Jiang Dongjun , Liu Yu , Zhang Zecai , Zhou Yulong , Zhu Zhanbo
Published: October 2023

Pasteurella multocida is a pathogen that can infect humans and animals. A ghost is an empty bacterial body devoid of cytoplasm and nucleic acids that can be efficiently presented by antigen-presenting cells. To study a novel ghost vector vaccine with cross-immune protection, we used bacteriophage PhiX174 RF1 and Pasteurella multocida standard strain CVCC393 as templates to amplify the split genes E and OmpH to construct a bidirectional expression vector E’-OmpH-pET28a-ci857-E. This is proposed to prepare a ghost Escherichia coli (engineered bacteria) capable of attaching and producing Pasteurella multocida OmpH on the inner membrane of Escherichia coli (BL21). The aim is to assess the antibody levels and the effectiveness of immune protection by conducting a mouse immunoprotective test. The bidirectional expression vector E’-OmpH-pET28a-ci857-E was successfully constructed. After induction by IPTG, identification by SDS-PAGE, western blot, ghost culture and transmission electron microscope detection, it was proven that the Escherichia coli ghost anchored to Pasteurella multocida OmpH was successfully prepared. The immunoprotective test in mice showed that the antibody levels of Pasteurella multocida inactivated vaccine, OmpH, ghost (aluminum glue adjuvant) and ghost (Freund’s adjuvant) on day 9 after immunization were significantly different from those of the PBS control group (P < 0.01). The immune protection rates were 100%, 80%, 75%, and 65%, respectively, and the PBS negative control was 0%, which proved that they all had specific immune protection effects. Therefore, this study lays the foundation for the further study of ghosts as carriers of novel vaccine-presenting proteins.
Neural stem/progenitor cells from adult canine cervical spinal cord have the potential to differentiate into neural lineage cells
Authors: Kim Woo Keyoung , Son Yeon Sung , Lim Ji-Hey , Kim Wan Hee , Kang Byung-Jae
Published: October 2023

Background

• Neural stem/progenitor cells (NSPCs) are multipotent self-renewing cells that can be isolated from the brain or spinal cord. As they need to be isolated from neural tissues, it is difficult to study human NSPCs. To facilitate NSPC research, we attempted to isolate NSPCs from dogs, as dogs share the environment and having many similar diseases with humans. We collected and established primary cultures of ependymal and subependymal cells from the central canal of the cervical spinal cord of adult dogs. To isolate pure NSPCs, we employed the monolayer culture and selective medium culture methods. We further tested the ability of the NSPCs to form neurospheres (using the suspension culture method) and evaluated their differentiation potential.

Results

• The cells had the ability to grow as cultures for up to 10 passages; the growth curves of the cells at the 3rd, 6th, and 9th passages showed similar patterns. The NSPCs were able to grow as neurospheres as well as monolayers, and immunostaining at the 3rd, 6th, and 9th passages showed that these cells expressed NSPC markers such as nestin and SOX2 (immunofluorescent staining). Monolayer cultures of NSPCs at the 3rd, 6th, and 9th passages were cultured for approximately 14 days using a differentiation medium and were observed to successfully differentiate into neural lineage and glial cells (astrocytes, neurons, and oligodendrocytes) at all the three passages tested.

Conclusion

• It is feasible to isolate and propagate (up to at least 10 passages) canine cervical spinal cord-derived NSPCs with the capacity to differentiate into neuronal and glial cells. To the best of our knowledge this is the first study to successfully isolate, propagate, and differentiate canine NSPCs derived from cervical spinal cord in the adult canine, and we believe that these cells will contribute to the field of spinal cord regeneration in veterinary and comparative medicine.
The effect of inhaled extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide on distal and central airway indices, assessed using Functional Respiratory Imaging in COPD (DARWiIN)
Authors: Skloot Gwen S. , Guasconi Alessandro , Lavon Benjamin R. , Georges George , De Backer Wilfried , Galkin Dmitry , Cortellini Mauro , Panni Ilaria , Bates Jason H. T.
Published: October 2023

Background

This study, in patients with symptomatic chronic obstructive pulmonary disease (COPD), explored switching therapy from non-extrafine high-dose inhaled corticosteroid/long-acting β2-agonist (ICS/LABA; fluticasone propionate/salmeterol [FP/SLM]) to extrafine medium-dose beclometasone dipropionate/formoterol fumarate dihydrate/glycopyrronium (BDP/FF/G), both via dry-powder inhaler. Functional Respiratory Imaging, a quantitative computed tomography method with 3D reconstructions of pulmonary anatomy, was used to assess airway geometry and lung function.

Methods

Patients receiving a stable ICS/LABA regimen for ≥ 8 weeks were switched to FP/SLM 500/50 µg, one inhalation twice-daily (high-dose ICS) for 6 weeks. After baseline assessments (Visit 2 [V2]), therapy was switched to BDP/FF/G 100/6/10 µg, two inhalations twice-daily (medium-dose ICS) for 6 weeks, followed by V3. The primary endpoints were percentage changes in specific image-based airway volume (siVaw) and resistance (siRaw) from baseline to predose at V3 (i.e., chronic effects), assessed at total lung capacity (TLC) in central and distal lung regions. Secondary endpoints included siVaw and siRaw changes from pre-dose to post-dose at V2, and from pre-dose to post-dose at V3 at TLC (i.e., acute effects), and chronic and acute changes in siVaw and siRaw at functional residual capacity (FRC). Pre-dose forced expiratory volume in 1 s (FEV1) and COPD Assessment Test (CAT) were also assessed.

Results

There were no significant changes in pre-dose siVaw or siRaw at TLC from baseline to V3, although at FRC there was a significant decrease in mean siRaw in the distal airways (− 63.6%; p = 0.0261). In addition, in the distal airways there were significant acute effects at TLC on mean siVaw and siRaw (siVaw: 39.8% and 62.6%; siRaw: − 51.1% and − 57.2%, V2 and V3, respectively; all p < 0.001) and at FRC at V2 (siVaw: 77.9%; siRaw: − 67.0%; both p < 0.001). At V3, the mean change in pre-dose FEV1 was 62.2 mL (p = 0.0690), and in CAT total score was − 3.30 (p < 0.0001).

Conclusions

In patients with symptomatic COPD receiving high-dose ICS/LABA, adding a long-acting muscarinic antagonist while decreasing the ICS dose by switching to medium-dose extrafine BDP/FF/G was associated with improved airway indices, especially in the distal airways, together with improvements in respiratory health status.

Trial registration ClinicalTrials.gov (NCT04876677), first posted 6th May 2021
Association of marine PUFAs intakes with cardiovascular disease, all-cause mortality, and cardiovascular mortality in American adult male patients with dyslipidemia: the U.S. National Health and Nutrition Examination Survey, 2001 to 2016
Authors: Tang Xuanfeng , Lv Xinyi , Wang Ruohua , Li Xiaoqing , Xu Wenyu , Wang Nan , Ma Shuran , Huang He , Niu Yucun , Kong Xiangju
Published: October 2023

Background

The relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease and mortality in dyslipidemic patients is unclear. Men with dyslipidemia have a higher risk of cardiovascular disease than women, and PUFA supplementation may be more beneficial in men.

Objective

The purpose of this study was to assess the relationship between different types of marine polyunsaturated fatty acids intakes and cardiovascular disease, all-cause mortality, and cardiovascular mortality in adult U.S. males with dyslipidemia.

Methods

The study ultimately included 11,848 adult men with dyslipidemia who were screened from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2016. This was linked to the 2019 National Death Index (NDI) records to establish a prospective cohort. In the study, a logistic regression model was established to assess the relationship between PUFA intake and prevalent CVD, and a Cox proportional hazards regression model was established to assess the relationship between PUFA intake and death.

Results

In the fully adjusted models, compared with participants in the lowest tertile, participants with the highest DPA intake were associated with a lower risk of CVD (CVD: OR = 0.71, 95%CI: 0.55, 0.91; angina: OR = 0.54, 95%CI: 0.38, 0.79; stroke: OR = 0.62, 95%CI: 0.43, 0.89), but not with three subtypes of congestive heart failure, coronary heart disease, and myocardial infarction. And the highest tertile level of DPA intake can reduce all-cause mortality (HR = 0.77, 95%CI: 0.64, 0.91) and CVD mortality (HR = 0.68, 95%CI: 0.52, 0.90).

Conclusions

Cardiovascular disease risk, all-cause mortality, and CVD mortality were inversely associated with dietary DPA intake but not EPA and DHA intakes in U.S. male participants with dyslipidemia.
MITIG.RA: study protocol of a tailored psychological intervention for managing fatigue in rheumatoid arthritis randomized controlled trial
Authors: Duarte Cátia , Spilker Ruben L. F. , Paiva Cláudia , Ferreira Ricardo J. O. , da Silva José A. Pereira , Pinto Ana M.
Published: October 2023

Background

Despite remarkable medical advances in the treatment of rheumatoid arthritis (RA), a subset of patients fails to achieve complete clinical remission, as the Patient Global Assessment (PGA) of disease activity remains above 1, even after the inflammatory process is brought under control. This so-called state of ‘PGA-near-remission’ negatively impacts individuals’ functioning and potentiates inadequate care. Fatigue is a distressing and disabling symptom frequently reported by patients in PGA-near-remission, and its management remains challenging. While classic cognitive-behavioural interventions show some benefits in managing fatigue, there is potential for improvement. Recently, contextual-cognitive behavioural therapies (CCBT), like mindfulness, acceptance, and compassion-based interventions, have shown promising results in fatigue-associated disorders and their determinants. This study primarily aims to examine the efficacy of the Compassion and Mindfulness Intervention for RA (MITIG.RA), a novel intervention combining different components of CCBT, compared to treatment-as-usual (TAU) in the management of RA-associated fatigue. Secondary aims involve exploring whether MITIG.RA produces changes in the perceived impact of disease, satisfaction with disease status, levels of depression, and emotion-regulation skills.

Methods

This is a single center, two-arm parallel randomized controlled trial. Patients will be screened for eligibility and willingness to participate and will be assessed and randomized to the experimental (MITIG.RA + TAU) or control condition (TAU) using computer randomization. MITIG.RA will be delivered by a certified psychologist and comprises eight sessions of 2 h, followed by two booster sessions. Outcomes will be assessed through validated self-report measures, including fatigue (primary outcome), perceived impact of disease, depressive symptoms, mindfulness, self-compassion, safety, and satisfaction (secondary outcomes). Assessment will take place at baseline, post-intervention, before the first and second booster sessions (weeks 12 and 20, respectively), and at 32 and 44 weeks after the interventions’ beginning.

Discussion

We expect MITIG.RA to be effective in reducing levels of RA-associated fatigue. Secondarily, we hypothesize that the experimental group will show improvements in the overall perceived impact of disease, emotional distress, and emotion regulation skills. Our findings will contribute to determine the benefits of combining CCBT approaches for managing fatigue and associated distress in RA.

Trial registration

ClinicalTrials.gov NCT05389189. Registered on May 25, 2022.
Response to Merz
Authors: Al Pepijn , Brehaut Jamie , Weijer Charles
Published: October 2023

Jon Merz raises two objections to our article on the ethics of behavioral influences in trial recruitment. In this response, we defend our article against these objections. We argue that Merz’s critique rests on a misunderstanding of our article, defend the daily life standard as a guardrail for leveraging cognitive biases, and argue that rejecting all behavioral influences is not a helpful nor a sustainable answer to their increasing use in trial recruitment.
Molecular characterization and functional implications on mouse peripheral blood mononuclear cells of annexin proteins from Echinococcus granulosus sensu lato
Authors: He Xue , Shao Guoqing , Du Xiaodi , Hua Ruiqi , Song Hongyu , Chen Yanxin , Zhu Xiaowei , Yang Guangyou
Published: October 2023

Background

Cystic echinococcosis (CE) is a life-threatening zoonotic disease caused by the larval stage of Echinococcus granulosus sensu lato, which employs various strategies to evade the host immune system for survival. Recent advances have revealed the role of annexins as excretory/secretory products, providing new insights into the immune regulation by these proteins in the pathogenesis of CE.

Methods

Echinococcus granulosus annexin B proteins EgANXB2, EgANXB18, EgANXB20, and EgANXB23 were cloned, expressed, and analyzed using bioinformatic tools. Membrane binding analysis was used to assess their bioactivity, while their immunoreactivity and tissue distribution characteristics were determined experimentally using western blotting and immunofluorescence staining, respectively. Furthermore, quantitative real-time reverse transcription PCR (qRT-PCR) was used to analyze the mRNA expression profiles of EgANXBs in different developmental stages of E. granulosus. Finally, immunofluorescence staining, cell counting kit 8 assays, flow cytometry, transwell migration assays, and qRT-PCR were used to evaluate the functional effects of rEgANXB18 and rEgANXB20 on mouse peripheral blood mononuclear cells (PBMCs).

Results

In this study, we identified four EgANXBs with conserved protein structures and calcium-dependent phospholipid binding activities. rEgANXBs were recognized by serum from sheep infected with E. granulosus and distributed in the germinal layer of fertile cysts. Interestingly, transcription levels of the four EgANXBs were significantly higher in protoscoleces than in 28-day strobilated worms. Moreover, we demonstrated that rEgANXB18 and rEgANXB20 were secretory proteins that could bind to PBMCs and regulate their function. Specifically, rEgANXB18 inhibited cell proliferation and migration while promoting cell apoptosis, NO production, and cytokine profile shifting. In contrast, rEgANXB20 showed limited effects on apoptosis but inhibited NO production.

Conclusions

Our findings suggested that among the four identified EgANXBs, EgANXB2 and EgANXB23 might play a pivotal role for the development of protoscoleces, while EgANXB18 and EgANXB20, as secretory proteins, appeared to participate in the host-parasite interaction by regulating the function of immune cells.

Graphical Abstract
Antibacterial activity of thymoquinone derivative
Authors: Mohammad Mohammad Yasin , Haniffa Haroon M. , Choudhary M. Iqbal
Published: October 2023

Natural products such as terpenoidal compounds have been extremely tested against pathogenic bacteria. Researches are frequently carried out to find out new natural, semisynthetic and synthetic antibacterial agents due to problems of resistance. Thymoquinone derivative was obtained in our previous study and the current research is a continuation. The antibacterial activity of a monoterpenoid; thymoquinone derivative, 5-isopropyl-2-methyloxepine-1-one (1) has been evaluated for the first time by following the Agar cup bioassay method employed. The bacterial strains used in this study were Escherichia coli and Bacillus subtilis. Compound 1 showed moderate activity against Gram-positive organism; B. subtilis and good activity against Gram-negative species; E. coli with zones of inhibition (ZOI) 10.0 ± 0.2 mm and 11.0 ± 0.2 mm against E. coli and B. subtilis, respectively, and in comparison with antibiotic, imipenem. The zones of inhibition were calculated as the mean of the triplicate. The antibacterial activity of thymoquinone derivative 1 could be explained by the presence of unsaturated lactone.
Validating the Dutch Eating Behavior Questionnaire for Children (DEBQ-C) among Korean children and adolescents with high weight
Authors: Kim Na Young , Suh Sooyeon , Kim Jieun , Son Kumhee , Woo Sarah , Kim Jia , Park Kyung Hee , Lim Hyunjung
Published: October 2023

Background

Using reliable measurement tools is becoming increasingly important as the prevalence of obesity among children increases in Korea. The Dutch Eating Behavior Questionnaire for Children (DEBQ-C) measures three eating behaviors associated with overeating. This study aims to validate the DEBQ-C for use among Korean children and adolescents with high body weight. It examines the psychometric features of the Korean translation of the DEBQ-C and investigates the relationship between the subscale scores of the DEBQ-C and the weight status of participants (categorized into overweight, obese, and morbidly obese).

Methods

A total of 233 children and adolescents (mean age: 11.4 ± 1.6 years) completed the questionnaire. The study verified the factor structure of the DEBQ-C using confirmatory factor analysis (CFA) and estimated its internal consistency with Cronbach’s alpha. For convergent validity, it employed Pearson’s correlation coefficient to assess relationships between the three eating behaviors of the DEBQ-C and the number of food addiction symptoms of the Yale Food Addiction Scale for Children (YFAS-C). Lastly, it examined the relationship between DEBQ-C scores and weight status via multinomial logistic regression analysis.

Results

The three-factor model demonstrated goodness-of-fit (χ2 = 253, df = 167, χ2/df = 1.515, p < 0.001, CFI = 0.944; TLI = 0.937; RMSEA = 0.047). The internal consistency of the three eating behaviors was also satisfactory (Cronbach’s alpha = 0.707–0.890). The emotional and external eating subscales of the DEBQ-C were positively correlated with the number of symptoms of food addiction of the YFAS-C. Emotional (OR: 2.008; 95% CI 1.973–2.043) and external (OR: 2.074; 95% CI 2.029–2.119) eating were positively associated with obesity status.

Conclusion

The results suggest that the Korean version of the DEBQ-C is suitable for the examination of problematic eating behaviors in Korean children and adolescents with high body weight.
Investigating the association of informal digital learning of English with EFL learners’ intercultural competence and willingness to communicate: a SEM study
Authors: Rezai Afsheen
Published: October 2023

Informal Digital Learning of English (IDLE), such as watching online videos, playing games, or chatting with English speakers beyond the classroom, has received increasing attention over recent years as a potential source of intercultural competence (IC) and second language willingness to communicate (L2 WTC) development among English as a Foreign Language (EFL) learners. However, little is known about how IDLE influences IC and L2 WTC among EFL learners, who face various challenges and opportunities in learning and using English in Iran. Thus, this research examined the relationship between IDLE and IC and L2 WTC in Iranian EFL learners. For this purpose, the study was conducted with the participation of 325 EFL learners from a language institute in Arak City, Iran, who were selected using convenience sampling. The participants completed the Digital Informal Learning Scale, the Intercultural Competence Scale, and the Willingness to Communicate Questionnaire. The results of the structural equation modeling revealed that IDLE had a significant positive association with both IC and L2 WTC. Further, the results indicated that IDLE dimensions, such as cognitive, meta-cognitive, social, and motivational aspects were significantly related to IC and L2 WTC. The findings approve that promoting IDLE among Iranian EFL learners could enhance their intercultural awareness and communication skills.
Factors predicting mental health in youth during the first COVID-19 lockdown in Spain
Authors: Vicario-Molina Isabel , Ortega Eva González , González Ruth Pinedo , Picos Andrés Palacios
Published: October 2023

Background

The first COVID-19 lockdown decreed in Spain by the government resulted in a significant disruption in the daily lives of youth that may have affected their mental health. The aim of this study was to identify factors that influenced youth mental health during this period. Methods: Between March and May 2020, a sample of 1205 youths (age range 18–24 years) from across Spain completed a questionnaire that assessed sociodemographic, mental health, loneliness, coping with humour and healthy habits. Data were analysed using Structural Equation Modelling.

Results

The proposed model showed good fit values, and significant variables explained 37% of mental health. loneliness, coping humour, healthy and unhealthy habits, and gender significantly predicted youth mental health.

Conclusions

The consequences of the pandemic and confinement derived from COVID-19 seemed to be especially severe for youth, increasing their mental health vulnerability. It is recommended that evaluating the long-term effects of confinement on this population, the mental health needs they may have and the support resources that would help meet them in situations of isolation, paying special attention to females.
A novel intraoperative continuous monitoring method combining dorsal cochlear nucleus action potentials monitoring with auditory nerve test system
Authors: Hosoya Makoto , Nagaoka Yuriko , Wakabayashi Takeshi , Shimanuki Marie N. , Nishiyama Takanori , Ueno Masafumi , Ozawa Hiroyuki , Oishi Naoki
Published: October 2023

Highly accurate real-time cochlear nerve monitoring to preserve cochlear nerve function is essential for simultaneous cochlear implantation and ipsilateral vestibular schwannoma resection. In the present study, we developed a novel real-time monitoring system that combines dorsal cochlear nucleus action potential monitoring with intracochlear stimulating electrodes (Auditory Nerve Test System, ANTS). We used this system for a case with vestibular schwannoma resection via the translabyrinthine approach. The monitoring system developed in this study detected highly reliable evoked potentials from the cochlear nerve every two seconds continuously during tumor resection. Near-total tumor resection was achieved, and cochlear implantation was performed successfully after confirming the preservation of cochlear nerve function in a case. The patient's hearing was well compensated by cochlear implantation after surgery. Our novel method continuously achieved real-time monitoring of the cochlear nerve every two seconds during vestibular schwannoma resection. The usefulness of this monitoring system for simultaneous tumor resection and cochlear implantation was demonstrated in the present case. The system developed in this study is compatible with continuous facial nerve monitoring. This highly accurate and novel monitoring method will broaden the number of candidates for this type of surgery in the future.
A multi-manifold learning based instance weighting and under-sampling for imbalanced data classification problems
Authors: Feizi Tayyebe , Moattar Mohammad Hossein , Tabatabaee Hamid
Published: October 2023

Under-sampling is a technique to overcome imbalanced class problem, however, selecting the instances to be dropped and measuring their informativeness is an important concern. This paper tries to bring up a new point of view in this regard and exploit the structure of data to decide on the importance of the data points. For this purpose, a multi-manifold learning approach is proposed. Manifolds represent the underlying structures of data and can help extract the latent space for data distribution. However, there is no evidence that we can rely on a single manifold to extract the local neighborhood of the dataset. Therefore, this paper proposes an ensemble of manifold learning approaches and evaluates each manifold based on an information loss-based heuristic. Having computed the optimality score of each manifold, the centrality and marginality degrees of samples are computed on the manifolds and weighted by the corresponding score. A gradual elimination approach is proposed, which tries to balance the classes while avoiding a drop in the F measure on the validation dataset. The proposed method is evaluated on 22 imbalanced datasets from the KEEL and UCI repositories with different classification measures. The results of the experiments demonstrate that the proposed approach is more effective than other similar approaches and is far better than the previous approaches, especially when the imbalance ratio is very high.
Preoperative demographics and laboratory markers may be associated with early dislocation after total hip arthroplasty
Authors: Lung Brandon E. , Donnelly Megan R. , Callan Kylie , McLellan Maddison , Taka Taha , Stitzlein Russell N. , McMaster William C. , So David H. , Yang Steven
Published: October 2023

Purpose

The purpose of this study was to identify modifiable medical comorbidities, laboratory markers and flaws in perioperative management that increase the risk of acute dislocation in total hip arthroplasty (THA) patients.

Methods

All THA with primary indications of osteoarthritis from 2007 to 2020 were queried from the National Surgical Quality Improvement Program (NSQIP) database. Demographic data, preoperative laboratory values, recorded past medical history, operative details as well as outcome and complication information were collected. The study population was divided into two cohorts: non‐dislocation and dislocation patients. Statistics were performed to compare the characteristics of both cohorts and to identify risk factors for prosthetic dislocation (α < 0.05).

Results

275,107 patients underwent primary THA in 2007 to 2020, of which 1,258 (0.5%) patients experienced a prosthetic hip dislocation. Demographics between non‐dislocation and dislocation cohorts varied significantly in that dislocation patients were more likely to be female, older, with lower body mass index and a more extensive past medical history (all p < 0.05). Moreover, hypoalbuminemia and moderate/severe anemia were associated with increased risk of dislocation in a multivariate model (all p < 0.05). Finally, use of general anesthesia, longer operative time, and longer length of hospital stay correlated with greater risk of prosthetic dislocation (all p < 0.05).

Conclusions

Elderly female patients and patients with certain abnormal preoperative laboratory values are at risk for sustaining acute dislocations after index THA. Careful interdisciplinary planning and medical optimization should be considered in high‐risk patients as dislocations significantly increase the risk of sepsis, cerebral vascular accident, and blood transfusions on readmission.
Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study
Authors: Motevalizadeh Ehsan , Díaz-López Andrés , Martín Francisco , Basora Josep , Arija Victoria
Published: October 2023

Context

Little is known about whether parity is associated with elevated early-pregnancy insulin resistance (IR), or whether overweight/obesity contributes to increasing the possible effect.

Objective

We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are affected by overweight/obesity.

Methods

A cross-sectional study was conducted of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socioeconomic status, obstetric history (including parity, ie, number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (≥1.58). Multivariable linear regression and Cox regression model with constant time were performed.

Results

Parity ranged from 0 to 4. After multivariable adjustment, the insulin levels (β [% change]: 20.92; 95% CI, 4.08-37.71) and HOMA-IR index (β [% change]: 19.72; 95% CI, 2.43-40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous [1 birth], β [% change[: 16.88; 95% CI, −1.00 to 37.99; multiparous [≥2 births), β [% change]: 32.18; 95% CI, 3.56-68.71), and an increased relative risk (RR) of an elevated IR (primiparous [1 birth], RR: 1.55; 95% CI, 1.03-2.36; multiparous (≥2 births), RR: 1.72; 95% CI, 1.05-2.83). The combination of multiparity and overweight/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.

Conclusion

This study demonstrates that parity may have a negative effect on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.
FRI073 Use Of Obesogenic Medications Among Patients With Type 2 Diabetes In The Dominican Republic
Authors: Agramonte Villar Scarlet P , Gil Vega Carlos R , Reynoso Ortiz Jose M , Sosa Pinedo Lisbeth R , Vasquez Morel Roberto A , Polanco Santos Carmen M , San Martin Vicente T
Published: October 2023

Disclosure: S.P. Agramonte Villar: None. C.R. Gil Vega: None. J.M. Reynoso Ortiz: None. L.R. Sosa Pinedo: None. R.A. Vasquez Morel: None. C.M. Polanco Santos: None. V.T. San Martin: None.

Background: Obesity is a major risk factor for the development and progression of type 2 diabetes mellitus (T2DM). Among the modifiable factors that can promote weight gain is the use of obesogenic medications (OM). The prevalence of the use of OM in patients with T2DM in the Dominican Republic (DR) is unknown. Objective: This study aimed to evaluate the use of OM among patients with T2DM in the DR. Methods: Cross-sectional study based on patient surveys and anthropometric measurements obtained in an outpatient primary care clinic in Santo Domingo, DR between October 2022 and November 2022. Patients aged ≥18 years with a known diagnosis of T2DM were included. Weight status was categorized according to body mass index (BMI). OM were defined according to the study by Hales et al1. Results: A total of 220 patients were surveyed and analyzed. Overall, 57.7% (127/220) of the patients reported a current use of one or more OM; 50.0% (110/220) were using one OM, 6.4% (14/220) were using two OM, and 1.3% (3/220) were using three OM. Among the patients using at least one OM, 45.7% (58/127) had overweight (BMI 25.0-29.9 kg/m2) and 40.9% (52/127) had obesity (BMI >30 kg/m2). The most frequently used antidiabetes OM was insulin [any type] (n=83), followed by glyburide (n=17) and glimepiride (n=13). The most commonly used non-antidiabetes OM was metoprolol (n=8), followed by atenolol (n=6) and pregabalin (n=6). Conclusion: More than half of the patients with T2DM were using at least one OM. The use of OM can contribute to weight gain and may hinder weight loss efforts in these patients, thus potentially negatively impacting the management of their underlying chronic disease. Reference: 1. Hales CM et al. Use of prescription medications associated with weight gain among US adults, 1999-2018: A nationally representative survey. Obesity (Silver Spring). 2022;30:229-239.

Presentation: Friday, June 16, 2023
SAT152 Retrospective Analysis Of HbA1c In Patients Diagnosed With Pancreatic Insulinoma Prior To- And After Surgical Excision
Authors: Lawless Sarah Jean , McGrath Aisling , Campbell Ruth , O'Keeffe Derek , Bell Marcia J
Published: October 2023

Disclosure: S.J. Lawless: None. A. McGrath: None. R. Campbell: None. D. O'Keeffe: None. M.J. Bell: None.

Insulinomas are rare pancreatic tumours characterised by episodes of hyperinsulinaemic hypoglycaemia. Patients may develop secondary diabetes following surgical intervention for insulinoma. Glycated haemoglobin (HbA1c) is a reliable bio-marker for the diagnosis and prognosis of diabetes. HbA1c is a useful surrogate marker for insulinoma (1). A retrospective analysis of patients diagnosed with insulinoma and attending our service in Galway University Hospital (GUH) was performed. Data was collected using the electronic patient correspondence system to gather information from clinic letters, hospital and GP laboratory results were accessed on the Evolve laboratory system. Diagnostic criteria employed a 72-hour fast with plasma glucose levels of ≤2.2 mmol/L, with a corresponding insulin level ≥18 pmol/L and a c-peptide of <200 pmol/l. We analysed their HbA1c at initial presentation and longitudinally following treatment. There are currently six patients carrying a diagnosis of insulinoma attending our service. All of these patients have had surgical intervention. At diagnosis four of the six patients had a HbA1c taken. One patient was diagnosed prior to HbA1c being routinely available and another patient had initial investigations and management elsewhere. The average HbA1c at time of diagnosis was 27.75 mmol/mol (n=4) (reference range 20 to 42 mmol/mol). All insulinoma patients have their HbA1c monitored yearly as part of ongoing follow-up. HbA1c trends upwards with an average HbA1c 18-24 months post surgical excision of 36.25 mmol/mol (n=4). There is a tendency of increased HbA1c post-operatively with a mean increase in HbA1c of 8.5 mmol/mol over 18-24 months. Three of our six patients have developed diabetes on extended follow-up. The average time to diagnosis post-surgical resection was 5.5 years (n=3). HbA1c is a useful tool for monitoring for secondary diabetes post pancreatic surgery. While admitting our number of patients is low, it is interesting to observe the difference in HbA1c pre- and post-operatively in patients with insulinoma. 1.Vaidakis, Dennis, et al. "Pancreatic insulinoma: current issues and trends." Hepatobiliary & pancreatic diseases international: HBPD INT 9.3 (2010): 234-241.

Presentation: Saturday, June 17, 2023
SAT153 A Case Of Hypoglycemia-induced Chest Pain Secondary To Adult Nesidioblastosis: A Case Report
Authors: Medina Espitia Oscar Leonardo , Altare Alejandro Quintero , Clavijo Veronica A , Martínez Delgado Laura C
Published: October 2023

Disclosure: O.L. Medina Espitia: None. A. Quintero Altare: None. V.A. Clavijo: None. L.C. Martínez Delgado: None.

The report of the present case in the medical literature is important in itself because of the infrequency of Nesidioblastosis. Additionally, it allows us to show unusual forms of presentation such as chest pain, and dynamic electrocardiographic changes in the ST segment with negative troponin, which coincide with episodes of hypoglycemia. At admission, the patient consulted the emergency department for a clinical presentation consisting of progressive retrosternal chest pain radiating to the left cervical region associated with dyspnea for medium exertion, palpitations, and dysautonomic symptoms, given by nausea. Due to episodes of chest pain, a coronary arteriography had been performed six months before admission without evidence of obstructive lesions. During hospitalization, episodes of hypoglycemia were observed. Remarkably, it was possible to document Dynamic ST changes in all EKG leads during episodes of hypoglycemia, as shown in Figure 1. Among the differential diagnoses, hypoglycemia secondary to adrenal or thyroid dysfunction was considered a first possibility, which was ruled out in the presence of normal paraclinical tests and medications that could generate hypoglycemia (negative sulfonylurea tests) were ruled out. A fasting test was performed with results showing endogenous hyperinsulinemic hyperinsulinemia with levels of insulin in 35.5 mg/dL, C-peptide 9.34 ng/dL and blood glucose 34 mm/dL. MRI of the abdomen without lesions. Due to a history of gastric bypass, endoscopic ultrasonography was not performed, therefore pancreatic calcium stimulation test was performed with evidence of a significant delta over the territory of the splenic artery. A distal pancreatectomy was obtained. Pathology report with findings suggestive of Nesidioblastosis (Figure 2.). There was a complete resolution of episodes of hypoglycemia and chest pain for two weeks. The recurrence of hypoglycemia episodes led to ambulatory treatment, with diazoxide with complete resolution of events.

Presentation: Saturday, June 17, 2023