bluuebunny/crossref_metadata_2025 huggingface dataset:
Current issues of animal welfare and health in pig breeding (review)
Authors: Paliy Anatoliy , Tsereniuk Oleksandr , Rybalko Valentyn
Published: August 2024

Objective. To summarise current issues related to welfare and health in pig production. Methods. Domestic and foreign sources of literature on the subject of research and their desk analytical analysis. Results. Today, animal welfare is determined by a combination of three interrelated components: the physical, mental and natural state of certain animals, as well as, of course, humane human attitude to meeting their needs. Until recently, the problems of humane treatment ofproductive animals were exclusively related to economically developed countries where intensive livestock production technologies were used. Pig farms need to have highly productive animals, adequate and balancedfeed, and use resource-saving technologies to produce breeding and marketable products at the optimum cost. Improving the efficiency of pig production primarily has a negative impact on the welfare of pigs. At the same time, it should be understood that, in general, pigs are raised to produce meat and lard products, which is directly related to their slaughter and, accordingly, the taking of their lives. Therefore, the needs of pigs will not be fully met. However, the basic needs - the so-calledfive freedoms of animals - must be met. A detailed grouping of approaches to determining animal welfare is formed in three main aspects: physical condition, mental condition and naturalness. It should be borne in mind that the satisfaction of specific needs in the natural environment does not always ensure their full satisfaction in the two aspects ofphysical and mental health. In the case of pig breeding, it is necessary to take into account the consequences of long term targeted selection of the main breeds and significant modification of their representatives compared to wild forms. The provision of air, water and feed for pigs is critical and should be provided in full. However, this is not always taken into account on Ukrainian pig farms. In addition, the welfare of pigs is inextricably linked and directly depends on the health of the animals. Conclusions. The review of literature sources to summarise current issues related to welfare in pig production indicates that there are a number of issues to be addressed in Ukraine. First and foremost, we are talking about EU legislation that should be implemented in domestic production, which is especially relevant on Ukraine's path to full EU membership. With regard to the existing pig welfare issues, the list of methods and approaches for determining certain indicators is gradually expanding, but it should be borne in mind that welfare in pig production is not limited to pig housing. These are issues related to the transport and slaughter of pigs, aspects that synergise with the subsequent safety of pig products. Of particular importance are the issues in which pig welfare intersects with biosecurity and ensuring appropriate animal health. Key words: pigs, welfare, animal health, housing, feeding, productivity, commercial pork production.
‘People look at you like you’re mad if you say good things about academia’: Collective Negativity, Anti-neoliberalism, and Hostility to Institutions in UK Higher Education – The Dark Side of Solidarity?
Authors: Butler Jessica Wren
Published: August 2024

Abstract Contemporary UK academia is riven with discontent: academics perform dissatisfaction on picket lines and social media, critiquing the so-called “neoliberal” university. This article draws on interviews with academic staff across England to consider the
implications of this turn to complaint, arguing that belief in the toxicity of neoliberal academia and a corresponding romanticised investment in a “golden age” of HE has become required thinking. Focusing on the perception that university management, as a metonym for the institution,
are suspect, I conclude that the prevalence of this belief, and its normative status, may promote solidarity between academics, but at a cost. If there is space for solidarity, the common ground upon which it is built appears to be dissatisfaction, negativity, and vocal disavowal of contemporary
trends. However, every collective act also contains tensions, contradictions, and exclusions, which may go unexamined, especially if the prevailing ideology is believed to be progressive.
Solidarity between Professors and Students in the Canadian University: Student Mental Health and the Always Already Mutating Professoriate
Authors: Tu Steve
Published: August 2024

Abstract Amid the mental health crisis plaguing Canadian university students, the professoriate is an underexplored, yet well-positioned resource. While campus wellness centres and other similar offerings are important interventions, they’re inadequate, requiring students
to take the initiative, which many won’t do. All students have professors, however, and this paper argues that the professoriate be re-imagined as a caring profession. Drawing on the work of Hazel Barnes, I argue that in the university-as-church, the professor is akin to clergy, and
as such, should exercise (non-religious) pastoral care. I present an ekphrastic reading of the ancient Greek myth of Ocnus to gesture toward the change that is possible in the professorial profession and the professor-student relationship.
Mifumo ya Ujinaishaji ya Wameru: Uchunguzi Tarafani Mwimbi katika Jimbo la Tharaka Nithi, Kenya
Authors: Mutegi David Micheni
Published: August 2024

Lengo la utafiti lilikuwa kubainisha mifumo ya Wameru ya ujinaishaji. Uchunguzi ulifanywa Skatika tarafa ya Mwimbi katika jimbo la Tharaka Nithi nchini Kenya kwa ambavyo hakuna uchunguzi wowote umefanywa kufikia sasa kubainisha namna Wameru wanavyojinaisha watoto. Swali la utafiti katika uchunguzi huu lilikuwa: Wameru huzingatia mifumo gani katika ujinaishaji wa watoto? Majibu kwa swali hili yalibainisha namna Wameru walivyochagua majina waliyowapa watoto. Idadi ya wahojiwa sabini waliteuliwa wakijumlisha vijana hamsini na wazee ishirini kwa kuwa makundi hayo na idadi hiyo ingekuwa kiwakilisho tosha cha wakaazi wa Mwimbi kwa kujibu swali la utafiti na kutosheleza madhumuni yake pia. Mbinu ya mahojiano yenye muundo ilitumiwa ambapo kila mhojiwa aliulizwa swali lile lile lililoulizwa mwingine. Mbinu hii ilifaa utafiti huu kwa vile kila mhojiwa alikuwa na uhuru wa kujieleza kwa hivyo habari nzito na nyepesi ziliweza kupatikana kwa ajili ya kuchuzwa na mtafiti. Utafiti huu uliongozwa na nadharia ya Uchanganuzi Hakiki Usemi na Matini na hasa zaidi ulizingatia Mtazamo Usemi Kihistoria wa Ruth Wodak. Ilibainika kuwa Wameru huwa na mifumo minne mahsusi ya ujinaishaji mathalani: sifabia za mtoto na za ntaguye, kutumia majina ya Ukoo, majina ya Rika na majina ya Nyoni. Mtafiti alipendekeza wazazi wawashirikishe vijana katika uteuzi wa majina ya watoto ili kuepuka mwelekeo hasi kuhusu majina yao wanapokua. Mapitio ya maandishi yalidhihirisha kuwa uchunguzi wa aina hii haujafanywa katika eneo hili kwa hivyo matokeo yalikuwa ni kichocheo kwa watafiti wengine wa kiisimu ambao wangependa kutafiti kuhusu mifumo ya ujinaishaji ya makabila mengine
Corporate Governance and Stock Return Volatility
Authors: Sari Dian Mega , Zaitul Zaitul
Published: August 2024

This research highlights the importance of corporate governance and helps investors and financial economists understand stock price behaviour after COVID-19. The study aims to find out the influence of the independent board of commissioners, and audit quality on the volatility of share returns in companies operating in the body care product sector and listed in the EIB in 2021-2022. In addition, this study also employs four control variables to avoid the model specification error. The population in this study is a company of body care products listed on the Indonesian Stock Exchange for the year 2021-202. The number of samples used is as many as eight companies in 2021-2022 based on purposive sampling methods that meet the sample selection criteria. The data analytical techniques used are descriptive statistical testing, classical assumption testing, and hypothetical testing using SPSS software version 25 and GRETL. The research results show that the independent board of commissioners and the audit quality influence share return volatility. As a sector directly related to daily consumer needs, the primary consumer goods sector tends to be highly responsive to changing trends and consumer preferences. It makes it interesting research subject to understand how the volatility of share returns in this sector reacts to external and internal factors.
Pengaruh Sistem Informasi Akuntansi dan Promosi terhadap Volume Penjualan dengan Kualitias Produk Sebagai Variabel Intervening di PT. Saudara Karya
Authors: Arifin Zaenal , Agus Agus , Hartadi Arif , Aziz M. , Riyadi Slamet , Pandin Maria Yovita R
Published: August 2024

Accounting information systems can aid businesses in enhancing sales volume and profitability, notwithstanding the challenge of increasing sales. This research investigates how promotions and management accounting information systems influence product quality, and explores whether product quality serves as a significant mediator. A survey was conducted among customers of PT. Saudara Karya Surabaya, involving 102 respondents selected through purposive sampling of customers who had completed at least one transaction. Structural equation modelling was employed to analyze the collected data. The findings indicate that both management accounting information systems and promotional strategies positively impact product quality. Furthermore, the study reveals that the relationship between promotions, management accounting information systems, and sales volume is mediated by product quality. This study contributes to the theoretical framework of marketing strategy by integrating concepts of product.
Pengaruh Harga dan Keragaman Produk terhadap Minat Beli Konsumen Bloods Clothing Industries Concept Store Karawang
Authors: Hermansyah Naoval Savira , Savitri Citra , Faddila Syifa Pramudita
Published: August 2024

This study aims to analyze the influence of price and product diversity dimensions on consumer purchase intention at Bloods Clothing Industries Concept Store Karawang. In the rapidly evolving fashion business context, Bloods Clothing Industries faces the challenge of intensifying competition in the market. The main issue under investigation is how Bloods Clothing Industries navigates the dynamics of competition and creates a strong consumer purchase intention. This research employs a quantitative approach by collecting data from consumers who visited the store during a specific period. The collected data is subjected to statistical analysis techniques, and the structural model is tested using SmartPLS 4.0 software. The research findings reveal that factors such as price and product diversity significantly influence consumer purchase intention. Price-related aspects, including affordability, price-quality alignment, price competitiveness, and price-benefit correspondence, play a crucial role in shaping purchase intention. Additionally, product diversity in terms of materials and design also has a positive impact on consumer purchase intention. The implications of this study suggest that Bloods Clothing Industries concept store Karawang should consider marketing strategies that focus on competitive pricing dimensions and diverse products appealing to consumers. A better understanding of the factors influencing purchase intention can assist companies in making informed decisions to confront competition and enhance customer loyalty.
Pengaruh Program Pelatihan UMKM dalam Pemanfaatan Teknologi Digital terhadap Produktivitas UMKM Kerupuk Rajungan Desa Sukajaya, Cilamaya Kulon
Authors: Anggraeni Silvi , Sungkono Sungkono , Retnosary Rieke
Published: August 2024

Based on observations, it is known that the main problem is the lack of a thorough understanding of sales technology that can increase the productivity of the crab crackers. This research intends to see if there is an effect of training on the utilization of digital technology on the productivity of umkm crab crackers in Sukajaya Village, Cilamaya Kulon. The total sample in the research was 93 people. Using quantitative method with simple linear regression analysis. According to observations, it is known that the case in the research is the lack of skills and understanding of digital technology that can increase productivity. based on the results of the simple linear regression test for productivity of 37.587%, based on the research conclusion shows that work learning has an absolute impact on the sales productivity of crab cracker MSMEs in Sukajaya Village, Cilamaya Kulon. Based on the results of the coefficient of determination (R2) value of 0.298, this case states that job training has an impact on productivity in the crab cracker SMEs of Sukajaya Village, Cilamaya Kulon Cilamaya Kulon as much as 29.8% while as much as 70.2% is influenced by other causes that are not tested. The conclusion of the research shows that training has an absolute effect on productivity.
Analisis Faktor yang Mempengaruhi Minat Mahasiswa dalam Berinvestasi
Authors: Fatchan Ilham Nuryana , Fatchan Fuad Hudaya , Achyani Fatchan , Wardana Candra Kusuma , Kholillulloh Fajar
Published: August 2024

This study aims to examine the influence of capital market training, financial literacy, research benefits, and research motivation on the investment interest of students from the Faculty of Economics and Business at Muhammadiyah University of Surakarta. Data were collected using a questionnaire through purposive sampling, with 86 respondents. The research employed validity testing, reliability testing, classical assumption testing, and multiple linear regression analysis. Findings from the t-test indicate that capital market training, financial literacy, investment benefits, and investment motivation significantly affect the investment interest of students in the Faculty of Economics and Business at Muhammadiyah University of Surakarta.
Meningkatkan Deduplikasi Data melalui Kesamaan Teks dalam Pembelajaran Mesin: Pendekatan Komprehensif
Authors: Handijono Ardijan , Suhatman Zaldy
Published: August 2024

The issue of dirty data, particularly duplicate data, is a common problem in data management that can affect data quality, operational efficiency, and decision-making. This study highlights the importance of implementing sustainable deduplication strategies as a key step in managing dirty data. We explore solutions for detecting duplicate data by measuring text similarity indices. In this study, the authors utilize a literature review research method. Through this method, we collected various journals on data deduplication and text similarity techniques, comparing several methods to identify the most effective approach. The data deduplication process in this study consists of two stages: 1) Matching - calculating the similarity value of a record with previous records, and 2) Clustering - grouping all records deemed duplicates of a single entity. Furthermore, this study extends to the development of a Python application capable of identifying and grouping similar customer data based on text similarity values. The Text Similarity measurement method uses the Jaro-Winkler Similarity technique. Experimental results and evaluations show that the Text Similarity approach is effective in identifying duplicate data with a high degree of accuracy. This study emphasizes the importance of sustainable deduplication, where the deduplication process is conducted periodically and continuously to ensure optimal data quality.
Peningkatan Kinerja Ditinjau dari Kepemimpinan Transformasional, Motivasi Kerja dan Kedisiplinan melalui Kualitas Sumber Daya Manusia pada Sekretariat Jenderal Dewan Ketahanan Nasional
Authors: Ardiansyah Reno , Mukrodi Mukrodi
Published: August 2024

This research aims to 1) To determine and analyze the influence of transformational leadership on the quality of human resources. 2) To determine and analyze the influence of work motivation on the quality of human resources. 3) To determine and analyze the influence of discipline on the quality of human resources. 4) To determine and analyze the influence of transformational leadership on employee performance. 5) To determine and analyze the influence of work motivation on employee performance. 6) To determine and analyze the influence of discipline on employee performance. 7) To determine and analyze the influence of the quality of human resources on the performance of Secretariat General Wantannas employees. The research method used in this research is a descriptive-quantitative statistical method using SmartPLS (Partial Least Square) software ver 3.2.8 with the PLS Analysis model. The population in this study was 140 people. In this research, the sampling technique used was simple random sampling. Thus, the number of saturated samples used was 100 respondents. The results of this research show that: 1) There is a positive and significant influence of Transformational Leadership on the Quality of Human Resources. 2) There is a positive and significant influence of work motivation on the quality of human resources. 3) There is a significant and significant influence of discipline on the quality of human resources. 4) There is a significant and significant influence of Transformational Leadership on Performance. 5) There is a positive and significant influence of work motivation on performance. 6) There is a positive and significant influence of discipline on performance. 7) There is a significant and significant influence on the quality of human resources on performance.
Strengthening the Implementation of Differentiated Learning in Inclusive Elementary Schools Through the OL (Organizational Learning) Approach
Authors: Trimurtini Trimurtini , Waluya Budi , Nugraheni Nursiwi , Bektiningsih Kurniana , Hendikawati Putriaji
Published: August 2024

The purpose of this community service activity is to improve the knowledge and skills of class teachers in designing differentiated learning programs. The method of implementing community service activities includes 4 stages that adopt the OL (Organizational Learning) approach. The four stages in OL are socialization, externalization, combination, and internalization. The results of the activities have been carried out in the socialization and externalization stages, where teachers have planned diagnostic tests for the basis for making differentiated learning tools. The participants' initial knowledge of differentiated learning scored 50, then increased by 39%, to reach a score of 89. The achievement of the score of increasing knowledge about differentiated learning exceeded the planned indicator of 75. The conclusion of the results of this Community Service activity is that the OL stage is used effectively in optimizing the understanding and practice of differentiated learning in Inclusion Elementary School.
Budidaya Tanaman Buah Jambu Demi Masyarakat yang Lebih Baik
Authors: Septanta Rananda , Nurhasan Yunus , Hidayat Raden Ai Lutfi , Ramdhani Chaeru Syahru
Published: August 2024

Red guava leaves are a type of medicinal plant that has many health benefits, including treating diarrhea in young children, reducing bad cholesterol (LDL) levels, preventing cancer, healthy skin, treating hair loss, treating gum disease, and a natural cure for diabetes. . The purpose of this community service is to provide information on how to increase the potential of natural resources located in Pamulang, which is an area that has quite high potential in the guava plant business in general, but currently it has not been utilized optimally by the local community at this time. Most of the guava plants that are produced are immediately sold individually without knowing the harvest that is consumed. This is due to a lack of innovation from the local community. Therefore, guava cultivation is one way that can be done by harvesting quite small or large areas of land that can be put to good use, maintain nutritional value, and increase economic value. With this cultivation empowerment, it is hoped that it can help improve the economy of the Pamulang community and take advantage of the harvest of guava plants for social welfare which is more durable to give rise to various innovations in guava processing itself in a sustainable manner.
ANALISIS AUDIT REPORT LAG: Dampak Pergantian Manajemen, Kompleksitas Operasional, dan Ukuran Perusahaan pada Consumer Non-Cyclicals di BEI (2019-2022)
Authors: Damayanti Riska
Published: August 2024

The purpose of this research is (1) to determine the effect of management changes, complexity of company operations, KAP size together on audit report lag. (2) to determine the effect of management changes on audit report lag. (3) to determine the effect of company operational complexity on audit report lag. (4) to determine the effect of KAP size on audit report lag.  This research is research that uses a quantitative approach. Furthermore, this research is a type of associative research. The data collection technique is a purposive sampling method. The data analysis methods in this research are descriptive statistical tests, research model tests, classical assumption tests, panel data regression tests and hypothesis tests. The results in this research are as follows: (1) management changes, complexity of company operations, KAP size together have a significant effect on. (2) change of management does not have a significant effect on audit report lag. (3) the complexity of company operations has a significant effect on audit report lag. (4) KAP size has a significant effect on audit report lag.
MINAT PENGGUNAAN CASHLESS PAYMENT SISTEM DOMPET DIGITAL PADA MAHASISWA DI PAPUA BARAT
Authors: Rahman Mohammad Arief , Warokka Ari , Priyati Rini Yayuk
Published: August 2024

This research examines the factors influencing the intention to use digital payment applications (cashless payments) among students in West Papua. Using the Unified Theory of Acceptance and Use of Technology (UTAUT) framework, this research analyzes the influence of self-efficacy, perceived risk, perceived usefulness, perceived ease of use, brand loyalty, and user attitudes on intentions to use cashless payment applications, as well as mediation potential user attitudes towards the influence of perceived usefulness and perceived ease of use. This research uses a questionnaire to apply a quantitative study of 342 West Papuan students. The analysis includes validity, reliability, and structural models. The research results show that self-efficacy and perceived risk do not significantly affect intention to use. In contrast, perceived usefulness, ease of use, brand loyalty, and user attitude have a significant effect. Besides that, user attitude can mediate the influence of perceived usefulness and ease of use on intention to use.
Openness to experience predicts eye movement behavior during scene viewing
Authors: Wyche Nicholas J. , Edwards Mark , Goodhew Stephanie C.
Published: August 2024

Individuals’ abilities to perform goal-directed spatial deployments of attention are distinguishable from their broader preferences for how they use spatial attention when circumstances do not compel a specific deployment strategy. Although these preferences are likely to play a major role in how we interact with the visual world during daily life, they remain relatively understudied. This exploratory study investigated two key questions about these preferences: firstly, are individuals consistent in their preferences for how they deploy their spatial attention when making shifts of attention versus adopting an attentional breadth? Secondly, which other factors are associated with these preferences? Across two experiments, we measured how participants preferred to deploy both attentional breadth (using an adapted Navon task) and eye movements (using a free-viewing task). We also measured participants’ working memory capacities (Experiment 1), and their personalities and world beliefs (Experiment 2). In both experiments, there were consistent individual differences in preference for attentional breadth and eye movement characteristics, but these two kinds of preference were unrelated to each other. Working memory capacity was not linked to these preferences. Conversely, the personality trait of Openness to Experience robustly predicted two aspects of eye movement behavior preference, such that higher levels of Openness predicted smaller saccades and shorter scan paths. This suggests that personality dimensions may predict preferences for more absorbed engagement with visual information. However, it appears that individuals’ preferences for shifts of attention during scene viewing do not necessarily relate to the breadth of attention they choose to adopt.
Tingkat Kepuasan Konsumen Terhadap Minuman Kopi Di Kopi Wulung Yogyakarta
Authors: Triyani Susi , Rukmini Ambar , Sari Anggri Sekar
Published: August 2024

Penelitian ini bertujuan untuk mengetahui tingkat kepuasan konsumen terhadap minuman kopi di Kopi Wulung Yogyakarta ditinjau dari Indikator kualitas produk, Indikator kualitas pelayanan, Indikator harga produk dan Indikator promosi produk. Metode penelitian yang digunakan yaitu kuantitatif dengan pendekatan deskriptif. Populasi penelitian ini adalah 300 konsumen di Kopi Wulung Yogyakarta. Sampel diperoleh dengan teknik simple random sampling sejumlah 75 konsumen. Pengumpulan data dilakukan dengan angket. Hasil uji validitas dari 39 butir pernyataan, diperoleh 37 butir soal valid dan 2 butir soal gugur. Hasil uji reliabilitas dinyatakan reliabilitas dimana nilai α = 0,763. Teknik analisis data yang digunakan yaitu analisis deskriptif, mean, median, modus dan standar deviasi. Hasil penelitian secara keseluruhan tingkat kepuasan konsumen termasuk dalam kategori puas dengan frekuensi relatif 53,2%. Hasil pada setiap indikator sebagai berikut (1) indikator kualitas produk termasuk dalam kategori sangat puas dengan presentase 34,3%, (2) indikator kualitas pelayanan termasuk dalam kategori sangat puas dengan presentase 37,5%, (3) indikator harga produk termasuk dalam ketegori cukup puas dengan presentase 26,8%, (4) indikator promosi produk termasuk dalam kategori puas dengan presentase 35,9%.
Elbow Bursitis, Spondylodiscitis and Meningitis Due to Streptococcus agalactiae: A Case Report
Authors: M Albuixech-Ginesta , A Villarejo-Jimenez , M Velasco-Nuno , M Serrano-Herran , MC Perez-Mendez , R Lazzari , M Puig-Campmany
Published: August 2024

Malaria remains one of the most important diseases in the world, being lethal to 610 thousand individuals annually. The widespread resistance of P. falciparum to antimalarials emphasizes the urgent need for new therapies, as treatment remains the primary strategy to control the disease. Although combinations of synthetic drugs are used in treatment, medicinal plants are often utilized in folk medicine as a complement and/or alternative to treat human malaria, especially in poor endemic areas. This systematic review evaluates the antiplasmodial and/or antimalarial activities, as well as the ethnopharmacological use of plant species by traditional communities from South America, through a search in the PubMed Central and Science Direct databases. Among 346 articles selected using the keywords “Malaria”, “Plants”, “Traditional”, “Knowledge”, “Antimalarial” and “Amazon”, 27 were considered eligible. Plant species with no activities were used to a new search on Google, PubMed, and Science Direct. Of the 389 species or genera from 88 botanical families evaluated, most studies were conducted in Peru, with leaves being the primary plant part used for treatment and/or prevention. Out of the analyzed species, excluding 30 mentioned only by genus, 185 had their extracts, fractions, or pure substances assessed, and only nine species had both in vitro and in vivo activity. Among the 174 species cited by traditional communities evaluated, with no data for activity, 66 presented results when a new literature search was performed. The Chayahuita ethnicity was the community providing more traditional knowledge about malaria treatment. Most plant species mentioned in the articles indicated for treatment and/or prevention of malaria have not yet been evaluated for antiplasmodial and antimalarial activities. Collecting ethnopharmacology information of plants is important, since their use for malaria treatment significantly increases the chances of finding a plant to be used as antimalarial substitutes.
TRPM7-Mediated Ca2+ Influx in Metabolic Reprograming
Authors: Zong Pengyu , Runnel Loren W , Yue Lixia
Published: August 2024

Metabolic reprograming is a process in which cells alter their biosynthetic and bioenergetic pathways to meet the changing energetic demands. To ensure energy supply, cancer cells increase glucose uptake and adapt their glucose metabolism from oxidative phosphorylation to aerobic phosphorylation. Metabolic reprograming towards aerobic glycolysis is also required for angiogenesis, as angiogenesis happens in tissues that in need of more blood (oxygen) supply. Although aerobic glycolysis was originally identified by Warburg nearly century ago, the molecular mechanisms regulating aerobic glycolysis remain elusive. In this issue of Cell death & disease (14, 183 (2023)), Wu and colleagues identified that by regulating calcineurin-CRTC2-CREB signaling pathway, TRPM7-mediated Ca2+ influx promotes the expression of glucose transporter 3 (GLUT3), which is needed for the programming of energy metabolism from oxidative phosphorylation toward aerobic glycolysis during tumorigenesis and angiogenesis. This study highlights the critical role of TRPM7 in metabolic reprogramming, and suggests that TRPM7 can be a molecular target for the treatment of other metabolic reprograming-related diseases.
Experience on Utilization of Novel Modeling & Simulation Approaches in Generic Product Development
Authors: Boddu Rajkumar , Kollipara Sivacharan , Rachapally Arvind , Ahmed* Tausif
Published: August 2024

Modeling and simulation approaches such as Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modeling (PBBM) are gaining importance due to their impact to transform drug development paradigm. Development of such modeling approaches include integration of drug substance, drug product and physiological aspects followed by validation against clinical data. In this manuscript, we have highlighted utility of PBPK and PBBM in generic product development using case examples. An application where PBBM was utilized to obtain biowaivers and dissolution safe space was portrayed. Utility of such modeling approaches in obtaining fed bioequivalence studies was discussed with case example. Impact of gender evaluation on bioequivalence study outcome using PBPK approach was highlighted with a case example. Evaluation of safety aspects of extended release formulation with help of modeling approach was discussed with practical example. In the last case study, understanding the impact of critical bioavailability attributes with help of PBBM was indicated. Further, future direction in terms of sharing best practices across academia, industry and regulatory was highlighted. Overall, this manuscript summarizes experience on utilization of modeling and simulation approaches in generic product development with an aim to have more affordable and quality medicines to the patients.
Clinical Analysis of Feeding Jejunostomy and Optimal Selection of Enteral Nutrients (Report of 238 Cases)
Authors: Tao Xiaomei , Zhang Xugang , Zhang Zhanzhi
Published: August 2024

The objectives of this study is to summarize and analyze the clinical and pathological data of patients with feeding jejunostomy, evaluate its clinical application value and risk, and study the optimal selection of enteral nutrients. The clinical data of 238 patients who underwent feeding jejunostomy in Beijing Shijitan Hospital, Capital Medical University, from September 1, 2017 to July 31, 2021 were retrospectively studied. The serious complications and treatment of patients were summarized and analyzed. Serious complications included anastomotic fistula, postoperative bleeding, and so on. Complications related to jejunal feeding stoma included: tube folded, intestinal stenosis at the stoma, and others. The symptoms of some enteral nutrition patients with abdominal pain, abdominal distension and diarrhea were improved by changing the type of enteral nutrients and increasing dietary fiber. Feeding jejunostomy can effectively solve the enteral nutrition problems of upper gastrointestinal anastomotic leakage, perforation, obstruction and functional eating disorder, can also be used as a separate means of enhance enteral nutrition support, but also can cause severe complications, and even death. Compliance with surgical indications is as important as mastery of surgical technical details. Reasonable use of enteral nutrients can achieve better nutritional support effect.
Screening and Identification of Streptomyces lavendulae against Walnut Rot Disease Cytospora chrysosperma
Authors: Liu Zhijin , Shan Lulu , Xu Shasha , Zhang Rui , Chen* Xiaofei
Published: August 2024

Streptomyces is a biocontrol agent capable of protecting walnut from stem rot disease caused by the fungal pathogen Cytospora chrysosperma. Antagonistic strains were selected from walnut rhizosphere soil for biocontrol of the disease. The strains were screened using C. chrysosperma as the target pathogen. Using dilution coating plate separation method, plate confrontation method, growth rate method and in vitro branch protection experiment, screening the antagonistic actinobacteria with inhibitory effect and control effect on walnut tree rot disease. Strains were identified based on their morphological, physiological, and biochemical characteristics, 16S rDNA sequencing, and phylogenetic analysis. The strain F-02 was identified as Streptomyces Lavendulae. Plate confrontation method tests showed that the inhibition rates of the Streptomyces strain F-02 on the pathogens were approximately 80.30%. Further study showed that the filtrate of strain F-02 couldinhibit the C.chrysosperma, and the widths of their inhibition zone reached 1.24±0.15 mm, the prevention effect of 71.03%. For the first time, S.lavendulae was used for the biological control of walnut tree rot. It provides strain resources for the development of walnut rot agents. It has potential applications for biological control of walnut tree rot disease.
PENDAMPINGAN PENGEMBANGAN MEDIA PEMBELAJARAN DENGAN MENGGUNAKAN AUTOPLAY STUDIO BAGI GURU MATEMATIKA DI KABUPATEN BONE BOLANGO
Authors: Arafat Muhammad Yasser , Salim Sardi , Larosa Esta , Pramudibyo Sugeng
Published: August 2024

The use of technology in education has become the main focus for increasing the effectiveness of learning in the classroom. This article explains the implementation of assistance in developing learning media using AutoPlay Studio for mathematics teachers in junior high schools in Bone Bolango Regency. The background is based on the challenges faced by teachers in integrating technology in mathematics learning as well as the urgency to improve their technology skills. Mentoring methods include the preparation stage, intensive training in using AutoPlay Studio, and teacher performance-based evaluation. Evaluation is carried out by looking at the teacher's active participation and mastery of technology. The results of the activity show a significant increase in teachers' mastery of AutoPlay Studio, with an increase in their ability to design and implement interactive learning media. Positive responses were also observed from students, indicating greater engagement and better understanding of the mathematical concepts taught. Ongoing evaluation and support, including follow-up sessions and mentoring, have proven crucial in ensuring continued implementation of this technology in the classroom. The results of this community service support the finding that structured training and ongoing evaluation are needed to maximize the effectiveness of the use of technology in mathematics education at the junior high school level.
BIMBINGAN TEKNIS DAN PENGUATAN KONTEN FISIKA SEBAGAI PERSIAPAN MENGIKUTI SELEKSI PROGRAM PENDIDIKAN PROFESI GURU
Authors: Muliani Muliani , Andriani Riza , Novita Nanda , Widya Widya , Idris Syafrizal , Sakdiah Halimatus , Fatwa Islami
Published: August 2024

Program profesi guru (PPG) memiliki tujuan utama untuk menghasilkan guru bersertifikasi, berkompeten dan professional yang berfungsi sebagai pemberdayaan guru. Rendahnya pengetahuan awal bagi mahasiswa calon guru terkait pelaksanaan teknis dalam mengikuti seleksi program PPG yaitu dimulai dari proses seleksi sampai ke tes substantif bidang keilmuan fisika. Maka kegiatan pengabdian ini diperlukan untuk memberikan bimbingan teknis sebagai persiapan mengikuti seleksi program PPG dan penguatan konten fisika bagi mahasiswa. Metode pelaksanaan terdiri dari 3 tahapan yaitu tahap persiapan, tahap pelaksanaan dan tahap evaluasi. Tahap pelaksanaan dilaksanakan 2 hari. Hari I melakukan bimbingan teknis terkait persiapan seleksi PPG. Hari II Melakukan bimbingan penguatan konten fisika. Subjek kegiatan adalah mahasiswa prodi pendidikan fisika yang berjumlah 39 orang. Instrumen yang digunakan soal pretes dan postes konten fisika yang berjumlah 10 soal dan Angket tingkat kepuasan peserta yang berjumlah 8 item pernyataan.  Hasil yang dicapai dalam kegiatan ini diperoleh nilai rata-rata pretes sebesar 48,21 sedangkan nilai postes 87.44. skor n-gain diperoleh 0.75 atau diperoleh persentase peningkatan sekitar 75%. Nilai rata-rata tingkat kepuasan terhadap kegiatan pelatihan 91.83% dengan kategori sangat memuaskan. Kesimpulan dari hasil pengabdian ini mahasiswa dapat memahami konsep teknis terkait seleksi mengikuti program profesi guru dan peningkatan pemahaman konten fisika.
Telaah Pentingnya Masjid dan Perannya dalam Islam Menurut Al-Imam Khomiini dalam Kitab al-Masjid Ahmiyatahu Wadu>rohu fi> al-Isla>m
Authors: Widodo Widodo , Basuki Basuki
Published: August 2024

Muslims often use mosques as centers of activity. The mosque being the axis of Islamic activities is very appropriate to be implemented in society, apart from being used for worship, it can also be used as a basis for society in life. This article explains the study of the importance of mosques and their role in Islam according to Al-Imam Khomiini in the book al-Masjid Ahmiyatahu Wadu>rohu fi> al-Isla>m. The primary data source in this research comes from the book al-Masjid Ahmiyatahu Wadu>rohu fi> al-Isla>m. Using secondary sources of information from books and articles relevant to the research theme through documentation techniques is a common and effective approach in research. Documentation techniques involve collecting data from various existing documents and literature. Then in content analysis, this research found the role of mosques according to Al-Imam Khomiini, namely: (1) mosques as the axis of Islamic activities (2) mosques as places of worship (3) mosques as a place to educate the next generation (4) mosque in building society. The results of the research show that mosques have a significant role in community life such as centers of worship, education centers, economic centers for the people, centers of social activities, and centers for the benefit of the people in Islamic society.
UPAYA ORANG TUA DALAM PEMBINAAN KEAGAMAAN ISLAM TERHADAP PELAJAR REMAJA DI MTSN 2 PAMEKASAN
Authors: Isbir Moh. , Azhari Jalaludin Faruk , Zubair Asyhari
Published: August 2024

This consider points to decide the part of guardians in cultivating Islamic devout instruction in youths, models and imperatives, and arrangements for guardians in cultivating Islamic devout instruction in teenagers at MTsN 2 Pamekasan. This investigate was conducted at MTsN 2 Pamekasan. This investigate approach is subjective investigate. Whereas this sort of investigate is phenomenological inquire about. The comes about of the ponder appear that the part of guardians in cultivating Islamic devout instruction in youthful children can be said to have been carried out well. These parts incorporate: As teachers, guardians instill devout values, give exhortation based on devout lessons, and welcome their youth to carry out devout exercises such as congregational supplications, perusing the Koran, Yasin, and so on. From the comes about of the ponder, it was moreover found that there are impediments as well as arrangements for guardians. Imperatives incorporate: Frequently young people disregard their commitments as Muslims, disregard orders from their guardians, and regularly spend their time playing smartphones, recreations, and social media. Whereas the arrangements from guardians incorporate guardians continuously prompting young people to comply Islamic lessons and not disregard their commitments. When exhortation does not make young people have self-awareness, guardians will reprove them by hollering at them, rebuking and prompting them indeed more solidly.
The Effectiveness Of Using Scrapbook Media To Improve Mufrodat Mastery Of Grade XI Of Al Hikmah Boarding School High School Batu
Authors: Abdul Muhith  , Munirul Abidin Munirul Abidin , Danial Hilmi Danial Hilmi , Mochammad Indra Yumanto Mochammad Indra Yumanto
Published: August 2024

This study aims to determine the effective of the influence using of scrapbook learning media on mufrodat mastery of eleventh grade students at Al Hikmah Boarding School High School Batu. This type of research is experimental research using a quantitative descriptive approach, as well as pre- and post-testing as data collection techniques. The population of this study is all students of Al Hikmah Boarding School Batu High School for the 2022-2023 school year. Data analysis techniques used to test hypotheses using SPSS 25.0-assisted multiple sample test formulas. Based on the results of pair 1 and pair 2 obtained sig. (2-tailed) from 0.000 < 0.05. Therefore, it can be concluded that there are differences in the average results of student mastery mufrodat for pre and post experimental classes and control classes. Then based on the results of the average score obtained from the pre- and post-test experimental categories, namely 48.27-71.54 in the experimental category and 51.54-58.85 in the control category. Therefore, it was concluded that Ha was accepted and Ho was rejected, which automatically shows that the using of scrapbook media in improving the mastery of the eleventh grade mufrodat of Al Hikmah Boarding School High School Batu is "effective".
STANDARISASI KEKERASAN DALAM RUMAH TANGGA DALAM PERSPEKTIF HUKUM KELUARGA ISLAM
Authors: Kadir Abdul
Published: August 2024

The aim of this study is to look at the standardization of domestic violence from the perspective of Islamic Family Law, in particular according to Mazhab Syafi’i, as well as the positive laws in force in Indonesia. KDRT is a serious problem that affects victims as well as families and society as a whole. As a Muslim-majority country, Indonesian law incorporates positive laws and Islamic values. This research uses qualitative methodology. Data in this research was collected through the study of literature from a variety of relevant sources, including books, journals, and legal documents. Mazhab Syafi’i’s view and positive law on the definition, legal action, and sanctions of the KDRT compared. The results of the research show that the KDRT is recognized by both Indonesian positive law and Mazhab Syafi’i as an act that violates the principles of justice and household welfare. However, there are differences in the way they deal with the KDRT issue and its enforcement. Through the integration of the perspective of Islamic law and positive law, the research is expected to make a significant contribution to the prevention and management of KDRT efforts in Indonesia, as well as improving protection and justice for KDRT victims. The benefits of the research include theoretical contributions to legal literature, improvement of public policy, empowerment of the public, and improved access to justice for the victims of the KDRT.
The Merits of Online Learning Communication in Overcoming The Constraints of Communication Offline Education
Authors: Erna Dwinata
Published: August 2024

This research highlights the weaknesses of communication patterns in offline learning which eventually become opportunities for online learning communication methods. The analysis in this study discusses the various advantages offered by online learning communication, revealing innovative methods and adaptive strategies that contribute to a more dynamic and effective way of delivering material experience. The method used in this study is the literature review method. Preparation of a literature review involves several stages, including finding relevant literature and evaluating literature sources. At the end of the findings will be presented 10 components that make online learning communication a tool to improve the practice of educational communication and overcome the challenges faced by conventional methods. Keywords: Online learning communication, offline learning communication, communication
The Effectiveness of Bi Al-Kitabah Da'wah through the Media of Nurul Jadid Islamic Boarding School Newspaper
Authors: Ina Septia Qorri 'Aina , Romadlany Zakiyah
Published: August 2024

ABSTRACT
This article discusses da'wah through print media (Bi Al-Kitabah). This paper aims to determine the effectiveness of spreading da'wah through print media, namely newspapers. In Islamic boarding schools, newspapers become an alternative medium for students to channel their thoughts and share knowledge. Being in the Pesantren environment does not close the boundaries for students in developing their insights. The development of technology today requires the younger generation to become an innovative and highly intellectual generation. Print media must now follow the flow of the times to maintain the existence of the media, one of which is by maintaining the actuality of writing. In the Nurul Jadid Paiton Islamic boarding school in Probolinggo – especially in the Qur'an Education Center of Nurul Jadid Islamic Boarding School, print media is the main media that is efficient and effective in disseminating information and knowledge for readers. In this descriptive qualitative research, researchers use data collection techniques through interviews, observations, and documentation from both offline and online sources. Based on the analysis of the collected data, it can be concluded that the use of print media in the form of newspapers in Islamic boarding schools can have a good impact on the development of knowledge, productivity of written works, and the effectiveness of spreading da'wah.
 
Keywords: Effectiveness, Da'wah Bi al-Kitabah, Print Media
 
ABSTRAK
Artikel ini membahas dakwah melalui media cetak (Bi Al-Kitabah). Tulisan ini bertujuan untuk mengetahui efektivitas penyebaran dakwah melalui media cetak, yaitu surat kabar. Di pesantren, koran menjadi media alternatif bagi santri untuk menyalurkan pikiran dan berbagi ilmu. Berada di lingkungan Pesantren tidak menutup batasan bagi mahasiswa dalam mengembangkan wawasannya. Perkembangan teknologi saat ini menuntut generasi muda untuk menjadi generasi yang inovatif dan intelektual tinggi. Media cetak kini harus mengikuti arus zaman untuk mempertahankan eksistensi media tersebut, salah satunya dengan menjaga aktualitas tulisan. Di pondok pesantren Nurul Jadid Paiton Probolinggo – khususnya di Pusat Pendidikan Al-Qur'an Pondok Pesantren Nurul Jadid, media cetak merupakan media utama yang efisien dan efektif dalam menyebarluaskan informasi dan pengetahuan bagi pembaca. Dalam penelitian kualitatif deskriptif ini, peneliti menggunakan teknik pengumpulan data melalui wawancara, observasi, dan dokumentasi baik dari sumber offline maupun online. Berdasarkan analisis data yang terkumpul, dapat disimpulkan bahwa penggunaan media cetak berupa surat kabar di pondok pesantren dapat berdampak baik bagi pengembangan pengetahuan, produktivitas karya tulis, dan efektivitas penyebaran dakwah.
 
Kata kunci: Efektivitas, Dakwah Bi al-Kitabah, Media Cetak