bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure 4 from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma
Authors: Hoppe Michal Marek , Jaynes Patrick , Shuangyi Fan , Peng Yanfen , Sridhar Shruti , Hoang Phuong Mai , Liu Clementine Xin , De Mel Sanjay , Poon Limei , Chan Esther Hian Li , Lee Joanne , Ong Choon Kiat , Tang Tiffany , Lim Soon Thye , Nagarajan Chandramouli , Grigoropoulos Nicholas F. , Tan Soo-Yong , Hue Susan Swee-Shan , Chang Sheng-Tsung , Chuang Shih-Sung , Li Shaoying , Khoury Joseph D. , Choi Hyungwon , Harris Carl , Bottos Alessia , Gay Laura J. , Runge Hendrik F.P. , Moutsopoulos Ilias , Mohorianu Irina , Hodson Daniel J. , Farinha Pedro , Mottok Anja , Scott David W. , Pitt Jason J. , Chen Jinmiao , Kumar Gayatri , Kannan Kasthuri , Chng Wee Joo , Chee Yen Lin , Ng Siok-Bian , Tripodo Claudio , Jeyasekharan Anand D.
Published: May 2023

Validation of prognostic significance of the M+2+6− subpopulation metric in gene-expression datasets. A, Distribution of single oncogene positivity in DLBCL cohorts as assessed by mfIHC (see Supplementary Fig. S9A and S9B). B, Impact of subpopulation metrics in GEP datasets on OS. Pooled univariate Cox PH model analysis; metric was used as a continuous variable in the model at 5% increments. HR per 5% increment with 95% CI is shown; CI are proportional on both tails but are capped at the graph's edges. Pooled P values were Bonferroni corrected to adjust for multiple testing and are shown for each subpopulation. C, Kaplan–Meier OS analysis of GEP cohorts stratified uniformly across absolute 15% M+2+6− metric into -high and -low groups. Log-rank test, shading denotes 95% CI. Total patient numbers in each group are shown. CMMC, Chi-Mei Medical Center.
Supplemental Figure S9 from Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Authors: Linde Miles H. , Fan Amy C. , Köhnke Thomas , Trotman-Grant Aaron C. , Gurev Sarah F. , Phan Paul , Zhao Feifei , Haddock Naomi L. , Nuno Kevin A. , Gars Eric J. , Stafford Melissa , Marshall Payton L. , Dove Christopher G. , Linde Ian L. , Landberg Niklas , Miller Lindsay P. , Majzner Robbie G. , Zhang Tian Yi , Majeti Ravindra
Published: May 2023

Primary B-ALL TR-APCs can be generated via exogenous
cytokine stimulation
Supplemental Figure S5 from Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Authors: Linde Miles H. , Fan Amy C. , Köhnke Thomas , Trotman-Grant Aaron C. , Gurev Sarah F. , Phan Paul , Zhao Feifei , Haddock Naomi L. , Nuno Kevin A. , Gars Eric J. , Stafford Melissa , Marshall Payton L. , Dove Christopher G. , Linde Ian L. , Landberg Niklas , Miller Lindsay P. , Majzner Robbie G. , Zhang Tian Yi , Majeti Ravindra
Published: May 2023

In vivo TR-APC induction drives oligoclonal T cell expansion
Supplemental Figure S2 from Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Authors: Linde Miles H. , Fan Amy C. , Köhnke Thomas , Trotman-Grant Aaron C. , Gurev Sarah F. , Phan Paul , Zhao Feifei , Haddock Naomi L. , Nuno Kevin A. , Gars Eric J. , Stafford Melissa , Marshall Payton L. , Dove Christopher G. , Linde Ian L. , Landberg Niklas , Miller Lindsay P. , Majzner Robbie G. , Zhang Tian Yi , Majeti Ravindra
Published: May 2023

In vivo TR-APC induction results in no observable off-target toxicity
Table S2 from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , Leonard-Louis Sarah , Ederhy Stéphane , Redheuil Alban , Boussouar Samia , Nguyen Lee S. , Procureur Adrien , Stein Frederic , Fenioux Charlotte , Devos Perrine , Gougis Paul , Dres Martin , Demoule Alexandre , Psimaras Dimitri , Lenglet Timothee , Maisonobe Thierry , De Chambrun Marc Pineton , Hekimian Guillaume , Straus Christian , Gonzalez-Bermejo Jesus , Klatzmann David , Rigolet Aude , Guillaume-Jugnot Perrine , Champtiaux Nicolas , Benveniste Olivier , Weiss Nicolas , Saheb Samir , Rouvier Philippe , Plu Isabelle , Gandjbakhch Estelle , Kerneis Mathieu , Hammoudi Nadjib , Zahr Noel , Llontop Claudia , Morelot-Panzini Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , Rosenzwajg Michelle , Similowski Thomas , Allenbach Yves
Published: May 2023

Diagnostic work-up for suspected ICI-myocarditis and evaluation of severity criteria
Supplementary Methods from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , Leonard-Louis Sarah , Ederhy Stéphane , Redheuil Alban , Boussouar Samia , Nguyen Lee S. , Procureur Adrien , Stein Frederic , Fenioux Charlotte , Devos Perrine , Gougis Paul , Dres Martin , Demoule Alexandre , Psimaras Dimitri , Lenglet Timothee , Maisonobe Thierry , De Chambrun Marc Pineton , Hekimian Guillaume , Straus Christian , Gonzalez-Bermejo Jesus , Klatzmann David , Rigolet Aude , Guillaume-Jugnot Perrine , Champtiaux Nicolas , Benveniste Olivier , Weiss Nicolas , Saheb Samir , Rouvier Philippe , Plu Isabelle , Gandjbakhch Estelle , Kerneis Mathieu , Hammoudi Nadjib , Zahr Noel , Llontop Claudia , Morelot-Panzini Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , Rosenzwajg Michelle , Similowski Thomas , Allenbach Yves
Published: May 2023

Methods concerning Immune-checkpoint proteins profiling on peripheral blood mononuclear cells and Circulating immune checkpoint agents drug monitoring
Supplementary Table 1 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Authors: Choe Joshua H. , Kawase Tatsuya , Xu An , Guzman Asja , Obradovic Aleksandar Z. , Low-Calle Ana Maria , Alaghebandan Bita , Raghavan Ananya , Long Kaitlin , Hwang Paul M. , Schiffman Joshua D. , Zhu Yan , Zhao Ruiying , Lee Dung-Fang , Katz Chen , Prives Carol
Published: May 2023

Summary of GOF vs. LOF activities of p53(A347D) in U2OS cells
Supplementary Data 5 from Li–Fraumeni Syndrome–Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death
Authors: Choe Joshua H. , Kawase Tatsuya , Xu An , Guzman Asja , Obradovic Aleksandar Z. , Low-Calle Ana Maria , Alaghebandan Bita , Raghavan Ananya , Long Kaitlin , Hwang Paul M. , Schiffman Joshua D. , Zhu Yan , Zhao Ruiying , Lee Dung-Fang , Katz Chen , Prives Carol
Published: May 2023

p53 ChIPseq peaks from U2OS cells varying in p53 allelic status
Data from Abatacept/Ruxolitinib and Screening for Concomitant Respiratory Muscle Failure to Mitigate Fatality of Immune-Checkpoint Inhibitor Myocarditis
Authors: Salem Joe-Elie , Bretagne Marie , Abbar Baptiste , Leonard-Louis Sarah , Ederhy Stéphane , Redheuil Alban , Boussouar Samia , Nguyen Lee S. , Procureur Adrien , Stein Frederic , Fenioux Charlotte , Devos Perrine , Gougis Paul , Dres Martin , Demoule Alexandre , Psimaras Dimitri , Lenglet Timothee , Maisonobe Thierry , De Chambrun Marc Pineton , Hekimian Guillaume , Straus Christian , Gonzalez-Bermejo Jesus , Klatzmann David , Rigolet Aude , Guillaume-Jugnot Perrine , Champtiaux Nicolas , Benveniste Olivier , Weiss Nicolas , Saheb Samir , Rouvier Philippe , Plu Isabelle , Gandjbakhch Estelle , Kerneis Mathieu , Hammoudi Nadjib , Zahr Noel , Llontop Claudia , Morelot-Panzini Capucine , Lehmann Lorenz , Qin Juan , Moslehi Javid J. , Rosenzwajg Michelle , Similowski Thomas , Allenbach Yves
Published: May 2023

Abstract
Immune-checkpoint-inhibitor (ICI)–associated myotoxicity involves the heart (myocarditis) and skeletal muscles (myositis), which frequently occur concurrently and are highly fatal. We report the results of a strategy that included identification of individuals with severe ICI myocarditis by also screening for and managing concomitant respiratory muscle involvement with mechanical ventilation, as well as treatment with the CTLA4 fusion protein abatacept and the JAK inhibitor ruxolitinib. Forty cases with definite ICI myocarditis were included with pathologic confirmation of concomitant myositis in the majority of patients. In the first 10 patients, using recommended guidelines, myotoxicity-related fatality occurred in 60%, consistent with historical controls. In the subsequent 30 cases, we instituted systematic screening for respiratory muscle involvement coupled with active ventilation and treatment using ruxolitinib and abatacept. The abatacept dose was adjusted using CD86 receptor occupancy on circulating monocytes. The myotoxicity-related fatality rate was 3.4% (1/30) in these 30 patients versus 60% in the first quartile (P < 0.0001). These clinical results are hypothesis-generating and need further evaluation.
Significance:
Early management of respiratory muscle failure using mechanical ventilation and high-dose abatacept with CD86 receptor occupancy monitoring combined with ruxolitinib may be promising to mitigate high fatality rates in severe ICI myocarditis.

See related commentary by Dougan, p. 1040.

This article is highlighted in the In This Issue feature, p. 1027
Supplementary Figures and Figure Legends from Breast Cancer Stem Cell–Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands
Authors: Raute Katrin , Strietz Juliane , Parigiani Maria Alejandra , Andrieux Geoffroy , Thomas Oliver S. , Kistner Klaus M. , Zintchenko Marina , Aichele Peter , Hofmann Maike , Zhou Houjiang , Weber Wilfried , Boerries Melanie , Swamy Mahima , Maurer Jochen , Minguet Susana
Published: May 2023

Supplementary Figures and Figure Legends
Table S7 from Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss
Authors: Erasimus Hélène , Kolnik Vanessa , Lacroix Frédéric , Sidhu Sukhvinder , D'Agostino Stéphane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: May 2023

sgRNAs against RAB10
Table S4 from Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss
Authors: Erasimus Hélène , Kolnik Vanessa , Lacroix Frédéric , Sidhu Sukhvinder , D'Agostino Stéphane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: May 2023

sgRNAscoreMageckComparison
FIGURE 6 from Genome-wide CRISPR Screen Reveals RAB10 as a Synthetic Lethal Gene in Colorectal and Pancreatic Cancers Carrying SMAD4 Loss
Authors: Erasimus Hélène , Kolnik Vanessa , Lacroix Frédéric , Sidhu Sukhvinder , D'Agostino Stéphane , Lemaitre Olivier , Rohaut Alexandre , Sanchez Isabelle , Thill Gilbert , Didier Michel , Debussche Laurent , Marcireau Christophe
Published: May 2023

Validation of the screen showing that disruption of RAB10 decreases proliferation specifically of SMAD4-deficient colorectal and pancreatic cancer cells. A, RAB10 expression assessed with Western blot analysis in the HT29_C4, SW620_C4, DLD1_C5 and MIAPaCa-2_C17 clones expressing Cas9 and infected with sgRNA against RAB10 (sgRNA #13 and sgRNA #14) and control nontargeting sgRNA (sgRNA #NT). B, Colony formation assay performed on inducible Cas9-expressing clones that were infected with lentivirus-carrying two sgRNAs targeting RAB10 (sgRNA #13 and sgRNA #14), and one nontargeting sgRNA. Briefly, cells were seeded at 500 cells/well in 12-well plates and cells were treated with 0.5–1 μg/mL doxycycline at day 3 post seeding. Two weeks later, cells were stained with Cristal violet and plates were scanned. C, Proliferation assay. Cells were seeded in T25 flasks at 3 × 105 cells/flask. They were counted and split regularly under doxycycline treatment for 20 days. The total cell number reached after 20 days was estimated using the population doublings that were calculated all along the experiments at each harvest steps. The proliferation percentage with SD of each clone is plotted according to the proliferation of the counterpart control cells having the nontargeting sgRNA (N = 2, t test sgRNA #13 vs. sgRNA #NT and sgRNA #14 vs. sgRNA #NT (*, P < 0.05; ***, P < 0.001; ns: nonsignificant). Note that the sgRNA used for the validation are distinct from the one present in the CRISPR screen library.
Data from EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
Authors: Chaudhary Ritu , Slebos Robbert J.C. , Noel Leenil C. , Song Feifei , Poole Maria I. , Hoening Dirk S. , Hernandez-Prera Juan C. , Conejo-Garcia Jose R. , Guevara-Patino Jose A. , Wang Xuefeng , Xie Mengyu , Tan Aik Choon , Chung Christine H.
Published: May 2023

Head and neck squamous cell carcinoma (HNSCC) has one of the most hypoxic and immunosuppressive tumor microenvironments (TME) among solid tumors. However, there is no proven therapeutic strategy to remodel the TME to be less hypoxic and proinflammatory. In this study, we classified tumors according to a Hypoxia-Immune signature, characterized the immune cells in each subgroup, and analyzed the signaling pathways to identify a potential therapeutic target that can remodel the TME. We confirmed that hypoxic tumors had significantly higher numbers of immunosuppressive cells, as evidenced by a lower ratio of CD8+ T cells to FOXP3+ regulatory T cells, compared with nonhypoxic tumors. Patients with hypoxic tumors had worse outcomes after treatment with pembrolizumab or nivolumab, anti-programmed cell death-1 inhibitors. Our expression analysis also indicated that hypoxic tumors predominantly increased the expression of the EGFR and TGFβ pathway genes. Cetuximab, an anti-EGFR inhibitor, decreased the expression of hypoxia signature genes, suggesting that it may alleviate the effects of hypoxia and remodel the TME to become more proinflammatory. Our study provides a rationale for treatment strategies combining EGFR-targeted agents and immunotherapy in the management of hypoxic HNSCC.
Significance:
While the hypoxic and immunosuppressive TME of HNSCC has been well described, comprehensive evaluation of the immune cell components and signaling pathways contributing to immunotherapy resistance has been poorly characterized. We further identified additional molecular determinants and potential therapeutic targets of the hypoxic TME to fully leverage currently available targeted therapies that can be administered with immunotherapy.
Bioresorbable Poly (L-Lactic Acid) Flow Diverter Versus Cobalt-Chromium Flow Diverter: In Vitro and In Vivo Analysis
Authors: Sasaki Natsuhi , Ishii Akira , Yagi Shinichi , Nishi Hidehisa , Akiyama Ryo , Okawa Masakazu , Abekura Yu , Tsuji Hirofumi , Sakurai Shinichi , Miyamoto Susumu
Published: May 2023

Background:

Permanent metallic flow diverter (FD) implantation for treatment of intracranial aneurysms requires antiplatelet therapy for an unclear duration and restricts postprocedural endovascular access. Bioresorbable FDs are being developed as a solution to these issues, but the biological reactions and phenomena induced by bioresorbable FDs have not been compared with those of metallic FDs.

Methods:

We have developed a bioresorbable poly (L-lactic acid) FD (PLLA-FD) and compared it with an FD composed of cobalt-chromium and platinum-tungsten (CoCr-FD). FD mechanical performance and in vitro degradation of the PLLA-FD were evaluated. For in vivo testing in a rabbit aneurysm model, FDs were implanted at the aneurysm site and the abdominal aorta in the PLLA-FD group (n=21) and CoCr-FD group (n=15). Aneurysm occlusion rate, branch patency, and thrombus formation within the FD were evaluated at 3, 6, and 12 months. Local inflammation and neointima structure were also evaluated.

Results:

Mean strut, porosity, and pore density for the PLLA-FD were 41.7 μm, 60%, and 20 pores per mm
2
, respectively. The proportion of aneurysms exhibiting a neck remnant or complete occlusion did not significantly differ between the groups; however, the complete occlusion rate was significantly higher in the PLLA-FD group (48% versus 13%;
P
=0.0399). Branch occlusion and thrombus formation within the FD were not observed in either group. In the PLLA-FD group, CD68 immunoreactivity was significantly higher, but neointimal thickness decreased over time and did not significantly differ from that of the CoCr-FD at 12 months. Collagen fibers significantly predominated over elastic fibers in the neointima in the PLLA-FD group. The opposite was observed in the CoCr-FD group.

Conclusions:

The PLLA-FD was as effective as the CoCr-FD in this study and is feasible for aneurysm treatment. No morphological or pathological problems were observed with PLLA-FD over a 1-year period.
A Re-Evaluation of the Role of Criminal law in Combating Parental Violence in the Netherlands
Authors: Satink Jeanette , Schuyt Pauline , Sombroek Mirjam
Published: May 2023

This article analyses the scope of the responsibility of the State to ensure access to criminal justice for child victims of parental violence from a children’s and human rights perspective and how this would serve the best interests of the child before, during and after criminal proceedings. The purpose of this article is to establish a human rights framework to promote better understanding of the multi-faceted problems inherent in the combat of parental violence by means of the criminal justice system, articulate obligations imposed upon States and facilitate a holistic approach. The article also explores to what extent the Netherlands, presented as a case study, meets the obligation to provide child victims of parental violence with access to criminal justice and whether there is a need to re-evaluate the role of criminal law in combating parental violence in the Netherlands.
The Analytical Concept of Asymmetrical Dependency
Authors: Winnebeck Julia , Sutter Ove , Hermann Adrian , Antweiler Christoph , Conermann Stephan
Published: May 2023

In response to critiques of the ‘slavery versus freedom’ binary and its limitations, researchers at the international Bonn Center for Dependency and Slavery Studies (BCDSS—www.dependency.uni-bonn.de) at the University of Bonn tentatively employ the analytical concept of ‘asymmetrical dependency’ in their investigations of coercive social relations, such as slavery, debt bondage, and servitude. In this paper, we discuss some basic theoretical assumptions that undergird this analytical concept. In outlining an approach to asymmetrical dependency that is grounded in social and cultural theory, our goal is to provide a framework within which individual researchers can situate their projects and further develop their theoretical understanding of this phenomenon. To this end, we first introduce the analytical concept of asymmetrical dependency and explore its potential in light of the current state of research of slavery studies and related fields. We then conceptualize asymmetrical dependency as a dynamic relational process and employ a chiefly praxeological methodology to identify and describe some fundamental dynamics of these relations. Finally, we argue that the interdisciplinary study of asymmetrical dependency requires a broad practice of comparative analyses. We, therefore, consider several recent critiques of and models for comparison while relating them to the analytical concept of asymmetrical dependency we propose.
Perisplenitis (“Sugar Spleen”) Associated With Malrotation of the Intestine in an Elderly Man
Authors: Barrios Evan L. , Matsuda M.K. , Stortz Julie A. , Smith Robert S. , Taylor Jessica E.
Published: May 2023

Intestinal non-rotation is an exceedingly rare clinical entity, especially as the etiology for small bowel obstruction following open-heart surgery in an elderly patient. Perisplenitis (also known as “sugar spleen”) is also rarely identified during exploratory laparotomy, and is more often encountered post-mortem due to its benign disease course. These two entities were encountered in the same acutely decompensating patient, and while unrelated, serve as a reminder of the importance of recognizing variations in anatomy and understanding subsequent clinical significance.
Colonic Perforation Secondary to COVID-19 Induced Hemorrhagic Colitis in a Patient Heterozygous for Factor V Leiden
Authors: Gherlone Nicole , Bhakta Priya , Apushkin Marsha , Zhu Richard
Published: May 2023

Up to 17.6% of COVID-19 positive patients present with gastrointestinal symptoms and bowel wall abnormalities have been described in up to 31% of COVID-19 positive patients. Here, we present a case of a 40-year-old male diagnosed with COVID-19 complicated by hemorrhagic colitis leading to colonic perforation. CT scan of abdomen and pelvis demonstrated markedly distended descending and sigmoid colon with poorly defined wall, pneumatosis, and pneumoperitoneum. The patient was taken for emergent exploratory laparotomy for extended left hemicolectomy, partial omentectomy, transverse colostomy creation, abdominal washout, repair of small bowel, and appendectomy. The patient was brought back for repeat exploratory laparotomy with ICG perfusion assessment. Patient was found to be heterozygous for factor V Leiden mutation and was never vaccinated for COVID-19. Our case demonstrates a novel use for indocyanine green (ICG) to assess perfusion and underscores the importance of completing a thorough hypercoagulable evaluation following COVID-19 induced thrombotic event.
Posterior Rectus Sheath Hernia Causing Chronic Abdominal Pain
Authors: Hammond Emily , Jones-Sayyid Caitlin , Langer Jason , Fox Elizabeth , Lawson Andrew
Published: May 2023

Posterior rectus sheath hernias are rare hernias that can be difficult to diagnose due to unreliable physical exam characteristics and subtle radiological findings. We present an interesting case of an elderly female found to have a posterior rectus sheath hernia during a diagnostic laparoscopy for chronic abdominal pain. CT evaluation revealed possible appendicitis and laxity of the abdominal wall of the right lower quadrant. Intraoperatively, a 4 cm hernia defect in the right lateral abdominal wall was appreciated. Appendectomy and herniorrhaphy with mesh repair were performed. Postoperative review of CT imaging and intraoperative photographs determined that this hernia defect is a posterior rectus sheath hernia likely caused by trocar placement from previous laparoscopic surgery. This report contributes to the limited body of the literature for this rare type of hernia. Posterior rectus sheath hernias should be considered in differential diagnoses for patients presenting with chronic abdominal pain without clear etiology.
Revealing and Mitigating Racial Bias and Discrimination in Financial Services
Authors: Scott Maura L. , Bone Sterling A. , Christensen Glenn L. , Lederer Anneliese , Mende Martin , Christensen Brandon G. , Cozac Marina
Published: May 2023

Three field studies and a laboratory experiment reveal racial discrimination in financial loan services. The results show that (1) service employees provide Black (vs. White) customers with inferior service outcomes (i.e., products offered), (2) Black (vs. White) customers experience inferior service processes (employees’ warmth/competence), and (3) Black (vs. White) customers report lower loyalty intentions toward the firm. Such discrimination is not only morally wrong and illegal; it is also bad for business. Therefore, the authors also show when and why racial discrimination is mitigated: namely, when Black customers signal higher socioeconomic status, or a Black customer's company (for which they seek the loan) has a more complex and sophisticated legal structure (corporation vs. sole proprietorship). Exploring this mitigation effect further, the authors show that a more sophisticated business structure increases the employee's trust toward Black customers, which reduces the perceived default likelihood and increases the likelihood to offer a loan; yet, this process does not emerge for White applicants. The findings point to managerial and policy implications to mitigate racial discrimination.
Gender Differences in Taste Sensations Based on Frequency Analysis of Surface Electromyography
Authors: Ullah Asif , Liu Yifan , Wang You , Gao Han , Luo Zhiyuan , Li Guang
Published: May 2023

Males and females respond differently at the muscular level to various tastes and show varied responses when eating different foods. In this study, we used surface electromyography (sEMG) as a novel approach to examine gender differences in taste sensations. We collected sEMG data from 30 participants (15 males, 15 females) over various sessions for six taste states: a no-stimulation physiological state, sweet, sour, salty, bitter, and umami. We applied a Fast Fourier Transformation to the sEMG-filtered data and used a two-sample t-test algorithm to analyze and evaluate the resulting frequency spectrum. Our results showed that the female participants had more sEMG channels with low frequencies and fewer channels with high frequencies than the male participants during all taste states except the bitter taste sensation, meaning that for most sensations, the female participants had better tactile and fewer gustatory responses than the male participants. The female participants responded better to gustatory and tactile perceptions during bitter tasting because they had more channels throughout the frequency distribution. Moreover, the facial muscles of the female participants twitched with low frequencies, while the facial muscles of the male participants twitched with high frequencies for all taste states except the bitter sensation, for which the female facial muscles twitched throughout the range of the frequency distribution. This gender-dependent variation in sEMG frequency distribution provides new evidence of differentiated taste sensations between males and females.
Reducing Test Anxiety During the COVID-19 Pandemic: A Comparison of the Effectiveness of Cognitive Behavioral Therapy and Acceptance and Commitment Therapy
Authors: Uysal Burcu , Gormez Vahdet , Karatepe Hasan Turan , Sönmez Dilruba , Taştekne Feyzanur , Tepedelen Mehmed Seyda , Jordan Timothy R.
Published: May 2023

Educational assessments can affect students’ mental health, particularly during a pandemic. Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT) are widely efficacious for reducing test anxiety, as well as general anxiety and rumination. However, the effectiveness of these two therapies for students during COVID-19 is unclear. We measured the effectiveness of ACT and CBT for managing test anxiety, general anxiety, and rumination during COVID-19 for 77 students taking Türkiye’s national university entrance exam, assigned to either the ACT or CBT psychoeducation programs. Both programs reduced test anxiety, general anxiety, and rumination, and showed similar levels of effectiveness. This suggests that ACT and CBT are both important for improving students’ mental health during COVID-19 and either may be beneficial.
Warp-knitted spacer fabric flexible composites with high stability and low-velocity impact resistance infused by flock-reinforced shear thickening gel
Authors: Tan Yuhao , Ma Yanxue , Li Yuling
Published: May 2023

Flexible protective materials with suitable properties are necessary for personal low-velocity impact (LVI) protection. Flock-reinforced shear thickening gel (FRSTG) can absorb energy through its state transition, thereby showing great potential in applications for LVI protection. However, the unstable state of FRSTG with a slight flow behavior challenges its LVI-resistant evaluation and in-depth development in use. Herein, three-dimensional (3D) warp-knitted spacer fabric (WKSF) composites were obtained by infusing FRSTG in high proportions (≥75%). FRSTG was observed to be stably and randomly distributed in the spacer layer of the WKSF, and the desirable flexibility of the composites was confirmed. The LVI protection effect of FRSTG was better than that of shear thickening gel at the same composite ratio, and the composite with an 83% FRSTG proportion absorbed more than 80% of the impact energy. Besides, FRSTG dominated the composites, showing enhanced responsiveness to the impact with increased velocity. Accordingly, this study constructed stable and LVI-resistant 3D flexible composites with FRSTG as the main functional component, which provided new ideas for the development of wearable protective equipment.
The Impact of the New York Nurse Practitioner Modernization Act on the Employment of Nurse Practitioners in Primary Care
Authors: Martsolf Grant R. , Kandrack Ryan , Ferrara Stephen A. , Poghosyan Lusine
Published: May 2023

Expanding scope of practice (SOP) for nurse practitioners (NPs) may increase NP employment in primary care practices which can help meet the growing demand in primary care. We examined the impact of enacting less restrictive NP practice restrictions—NP Modernization Act—in New York State (NYS) on the overall employment of primary care NPs and specifically in underserved areas. We used longitudinal data from the SK&A outpatient database (2012-2018) to identify primary care practices in NYS and in the comparison states (Pennsylvania [PA] and New Jersey [NJ]). Using a difference-in-differences design with an event study specification, we compared changes in (1) the presence and (2) total counts of NPs in primary care practices in NYS and neighboring comparison states (ie, PA and NJ) before and after the policy change. The NP Modernization Act was associated with a 1.3 percentage point lower probability of a practice employing at least one NP on average across each of the 3 post-periods (95% CI: −.024, −.002). NP Modernization Act was associated with 0.065 fewer NPs on average across the post-period (95% CI: −.119, −.011). Results were similar in underserved areas. NP employment in primary care practices in NYS was lower after the NP Modernization Act than would have been expected based counterfactual of comparison states. The negative relationship may be explained by gains in provider efficiency which leads to reduced NP hiring in primary care. More research is needed to understand the relationship between SOP regulations, NP supply, and access to care.
Mobility Repertoires: How Chinese Overseas Students Overcame Pandemic-Induced Immobility
Authors: Liu Jiaqi M. , Peng Rui Jie
Published: May 2023

The burgeoning field of immobility studies focuses on how migratory aspirations and capabilities shape a given (im)mobility status but devotes scant attention to how people traverse different (im)mobility categories. Through a case study of Chinese students in the United States during the COVID-19 pandemic, this article develops two arguments to shed light on migrants’ experiences and strategies in mobility transitions. First, during the pandemic, while China's restrictive travel policies and unfavorable public discourses made return migration extremely difficult, Chinese overseas students also felt unwelcome in the United States, due to visa restrictions and Sinophobic violence. This dilemma of being unable to return to the homeland and being simultaneously stranded in a hostile host society pushed Chinese student migrants, a previously highly mobile population, into immobility. Second, drawing on in-depth interviews, we discover that Chinese overseas students deployed four sets of tools—online crowdsourcing, virtual intermediary, temporal adaptation, and institutional cushioning—to reclaim mobility. We propose the concept of “mobility repertoires” to capture social actors’ active retooling and deliberate restrategizing of digital, cognitive, and institutional resources to navigate unsettling (im)mobility predicaments and construct new mobility tactics. By cross-fertilizing studies of immobility and migration infrastructure, we provide an action-centered, processual account of (im)mobilities as agential practices and robust courses of action, rather than static statuses or categories. This article also transcends the mobility bias in the literature on international student mobility (ISM) by unraveling the co-production of international student immobility by migration policies and discursive constraints in host and home countries.
The Making of a “Lost Generation”: Child Labor among Syrian Refugees in Turkey
Authors: Dayıoğlu Meltem , Kırdar Murat Güray , Koç İsmet
Published: May 2023

Millions of children are forcibly displaced worldwide due to wars, civil conflicts, and natural disasters. Displacement disrupts the lives of children making child labor a serious risk. However, little is known about this topic due to the difficulty of finding datasets for this population. In this study, we use a large representative dataset of Syrian refugees in Turkey, the largest refugee group in any single country, to examine the incidence of child labor and its determinants. The incidence of paid work is remarkably high among boys: 18.8 percent of 12–14 year-olds and 48.0 percent of 15–17 year-olds are in paid employment. These percentages are considerably higher than the corresponding values we estimate for pre-war Syria at 7.6 percent and 29.0 percent, respectively. We find that children from poorer households with more dependents and younger, less educated, and female household heads and children living in industrialized regions of Turkey and originating from rural Syria are more likely to work. A key finding is that being older at arrival is highly associated with child labor. Difficulties with school integration, on the one hand, and availability of job opportunities, on the other, have created a group of young out-of-school children at work. Placing these children in vocational training that allows them to work while learning a trade under the scrutiny of the Ministry of Education may help protect their well-being.
Incidence and clinical impact of silent pancreatitis after aortic arch surgery
Authors: Ohno Tsukasa , Mutsuga Masato , Saito Shunei , Tokuda Yoshiyuki , Nagai Keiichi , Umemoto Norio , Abe Tomonobu , Usui Akihiko
Published: May 2023

Background

This study was designed to investigate the incidence and types of pancreatic injury, risk factors, and time-course changes in computed tomographic findings following total aortic arch replacement with moderate hypothermic circulatory arrest.

Methods

Medical records of patients who underwent total arch replacement between January 2006 and August 2021 were retrospectively reviewed. A comparison study between the patients with (group P) and without pancreatic injury (group N) was conducted to elucidate the impact of pancreatic injury. Follow-up computed tomography of the patients in group P was reviewed to investigate time-course changes of the pancreatic injury.

Results

Of 353 patients, 14 (4.0%) had subclinical pancreatic injury. Computed tomographic findings were consistent with acute pancreatitis in all patients, of whom eight patients had interstitial edematous pancreatitis, whereas six patients had necrotizing pancreatitis. Although walled-off necrosis occurred in three patients, none of them required drainage. In-hospital mortality was 7.1% and 4.4% in groups P and N, respectively ( p  =  0.98). The 5-year actuarial survival rates were 77.9% and 81.0% in groups P and N, respectively ( p  =  0.51). Multivariate analysis revealed that pancreatic injury was associated with chronic obstructive pulmonary disease ( p  =  0.03).

Conclusions

This study highlighted that silent pancreatic injury after aortic arch surgery is underrecognized. Potential arterial sclerosis of the pancreatic circulation seems to be related to pancreatic injury.
Annual review article: The dual mindset of design-driven entrepreneurship: The case for a pedagogy of making and artefact-centred entrepreneurship education
Authors: Iandoli Luca
Published: May 2023

In the last decade, new design-driven approaches, such as Design Thinking, Customer Discovery, and Lean Start-up, have gained popularity in entrepreneurship education (EE). However, their adoption has been characterised by confusion in understanding their theoretical underpinnings and the challenge of introducing these new methods into a pedagogic culture emphasising ideation over experience, emotional intelligence, and making. This article argues that the implementation of these new pedagogic approaches can be improved by better translating the principles of design-driven and artifact-centered entrepreneurship into pedagogical practices. To achieve this goal, a model for a pedagogy of making in EE is proposed along with theoretical and economic arguments based on recent advances in the debate on entrepreneurship as a design science, the growing importance of intangibles in the economy, and the challenges of artificial intelligence (AI) to the job market and student employability. The critical elements for successfully adopting such pedagogy and common misconceptions that can hinder its full deployment are outlined.
Comparing Direct Demand Models for Estimating Pedestrian Volumes at Intersections and Their Spatial Transferability to Other Jurisdictions
Authors: Sobreira Lucas Tito Pereira , Hellinga Bruce
Published: May 2023

Direct demand (DD) models are used to estimate pedestrian volumes at intersections as a function of readily available variables, such as land use and socioeconomic features. The objectives of this paper are: (1) to identify and qualitatively assess existing DD models in the literature; and (2) to evaluate the spatial transferability of DD models for estimating annual average daily pedestrian traffic (AADPT) at signalized intersections. Six DD models developed from jurisdictions with varying characteristics were selected for spatial transferability assessment. The models were applied to three jurisdictions (Milton, Canada; Pima County, U.S.; and Downtown Toronto, Canada) that had notable differences in the level of pedestrian activity, land use, and socioeconomics. Observed pedestrian volumes were obtained for sites in each jurisdiction. The DD models performed considerably differently across jurisdictions. Five of the models performed reasonably well for Milton, a jurisdiction that is comparable to those considered in the calibration of the selected DD models and that shares characteristics with many suburban Canadian and U.S. jurisdictions. Overall, the applications for Pima County and Downtown Toronto, which have extremely low and high pedestrian volumes, respectively, provided poor accuracy. This paper demonstrated the potential for transferring existing DD models to other jurisdictions; but also identified the clear need for further research to improve the spatial transferability of DD models.
Improved Nighttime Traffic Detection Using Day-To-Night Image Transfer
Authors: Guo Feng , Liu Jian , Xie Quanyi , Chang Honglei
Published: May 2023

With the rapid development of convolutional neural networks (CNNs), real-time traffic monitoring, which benefits both traffic optimization and management, has been widely applied with smart cameras on streets. However, compared with the daytime traffic detection, nighttime traffic detection is limited by labeling annotations and is thus unstable, inaccurate, and inefficient in practice. To address this issue, this study proposes to use the augmented nighttime traffic images generated by cycle generative adversarial networks (CycleGAN) for better nighttime detection performance. Using CycleGAN, transferred nighttime traffic images are generated by using the daytime traffic images, as both share the same annotations of traffic instances in the daytime. For comparison, different learning rates and crop sizes are adopted for day-to-night traffic image transfer. The previously proposed detection network, dense traffic detection network (DTDNet), is adopted to train the prepared image data set. The indicators of mean average precision (mAP), precision, and recall are adopted for training performance evaluation and comparison. Based on the visualization results, CycleGAN, with a learning rate of 2e-5 and a crop size of 64, has better performance on day-to-night traffic image transfer with our proposed image data set. Considering the indicators of training performance, DTDNet, with 60% of transferred nighttime images and 40% of the original images, has better accuracy in four categories. Overall, this study provides a possible solution for addressing the issue of training data limitation in nighttime traffic detection and demonstrates the potential of GAN-based data augmentation in the transportation domain.
The Spectrum of Pediatric Infection-Associated Intracranial Arteriopathies and Acute Ischemic Stroke at 2 Eastern Indian Tertiary Care Centres
Authors: Das Suman , Ray Biman Kanti , Mishra Lopamudra , Chatterjee Kaushani , Mondal Gobinda , Paul Dilip Kumar
Published: May 2023

Introduction

Major and minor pediatric infections may cause intracranial arteriopathies, the long-term outcome of which we investigated and identified the factors influencing the progression/resolution of arteriopathies.

Methods

We collected the clinical and radiological data of children aged 1 month–15 years who had ischemic stroke with definite arteriopathy following a recent febrile infection. Repeated neuroimaging was done over the next year to ascertain recurrent strokes and the progression and resolution of arteriopathies.

Results

The anterior circulation was more frequently affected (83.33%), predominantly involving the middle cerebral artery (41.67%), resolving in 20.84% of cases and progressing in 33.33% of cases. Lesions were commonly unilateral (54.17%) and stenotic (75%), resulting predominantly in cortical infarcts (45.83%), with hemiparesis being the most common neurodeficiency. Apart from tubercular meningitis patients, others had a good functional outcome.

Conclusion

Lower age, minor infections, and unilateral arteriopathies had a significantly higher chance of resolution. Postviral arteriopathies had a significantly lower chance of progression compared with those following bacterial infections. Progressive and bilateral arteriopathies were significantly associated with worse outcomes and recurrent strokes.
Hybrid musculoskeletal model-based 3D asymmetric lifting prediction and comparison with symmetric lifting
Authors: Xiang Yujiang , Zaman Rahid , Arefeen Asif , Quarnstrom Joel , Rakshit Ritwik , Yang James
Published: May 2023

In this study, a 3D asymmetric lifting motion is predicted by using a hybrid predictive model to prevent potential musculoskeletal lower back injuries for asymmetric lifting tasks. The hybrid model has two modules: a skeletal module and an OpenSim musculoskeletal module. The skeletal module consists of a dynamic joint strength based 40 degrees of freedom spatial skeletal model. The skeletal module can predict the lifting motion, ground reaction forces (GRFs), and center of pressure (COP) trajectory using an inverse dynamics-based motion optimization method. The musculoskeletal module consists of a 324-muscle-actuated full-body lumbar spine model. Based on the predicted kinematics, GRFs and COP data from the skeletal module, the musculoskeletal module estimates muscle activations using static optimization and joint reaction forces through the joint reaction analysis tool in OpenSim. The predicted asymmetric motion and GRFs are validated with experimental data. Muscle activation results between the simulated and experimental EMG are also compared to validate the model. Finally, the shear and compression spine loads are compared to NIOSH recommended limits. The differences between asymmetric and symmetric liftings are also compared.
The effect of secondary passages on cavitation and radial forces in a liquid propellant turbopump
Authors: Moganaradjou Yashwant , Phukan Anindita Apurbaa , Vengadesan S , Chatterjee Dhiman , Prejil Kumar B , Rijish Kumar P , Unnikrishnan Nair P
Published: May 2023

Numerical studies on rocket pumps are computationally expensive and hence the secondary passages such as sidewall clearance gaps, wear ring gaps, axial balancing mechanism, coolant/lubricant paths, etc. in the pump are usually not considered. In this study, a liquid propellant pump with and without secondary passages are modelled and flow simulation results are compared to analyse the differences in cavitation, vortices and radial force predictions arising due to the presence/absence of the secondary flow passages. Single-phase and multiphase simulations are conducted for the design and two off-design points. It is predicted that the presence of secondary passages has a significant effect on the type of cavitation instability predicted and on the volume of cavity generated in the inducer due to which the radial forces generated also differ significantly. The presence of secondary passages predicted large fluctuations from the average radial forces generated by the inducer. These are not obtained if the leakages are not considered. This type of underprediction during the design phase might cause severe wear and tear in the bearings during actual operation. Thus, this study stresses the need for incorporating the secondary passages even at the design stages. This study also highlights the possibility of cavitation instability type manipulation using some means in the inducer which would be significant for cavitation control research in rocket pumps.
The politics of Chinese immigrants’ double unbelonging and deglobalization
Authors: Gao Zhipeng
Published: May 2023

This study theorizes the politics of belonging, drawing on the case of Chinese immigrants. In the heyday of globalization, Chinese immigrants used to enjoy a high degree of transnational mobility and multiple belongings. Now, in the wake of China–West geopolitical contestations and during the time of COVID-19, many Chinese immigrants are experiencing double unbelonging due to marginalization in both the host society and China. By analyzing double unbelonging, this study makes three theoretical contributions. First, it expands the conventional cultural–humanistic framework of belonging to incorporate political analysis. Second, it discusses why and how to replace the positivist approach to belonging as exemplified by acculturation theory with a social constructionist approach to the politics of belonging. Finally, the study theorizes unbelonging—its epistemological advantage, its dialectical relation with belonging, its production by the nation-state and media, and how polarizing geopolitics produce double unbelonging.
Introduction: Theorizing the psychology of deglobalization
Authors: Gao Zhipeng , Teo Thomas
Published: May 2023

The unprecedented pace and scope of globalization over the past half century have had major impacts on the field of psychology. We observe that since the 2008 financial crisis, there have been increased academic and political concerns with “deglobalization,” which is often associated with terrorism, xenophobia, authoritarianism, Brexit, the US–China trade war, the Russian war on Ukraine, and the COVID-19 pandemic. We argue that the phenomenon of deglobalization is historically uncertain but intellectually and politically significant enough to warrant analysis. Thus, in this special issue, we begin to theorize the psychology of deglobalization by addressing several foundational issues: the major manifestations of deglobalization in relation to psychosocial life, the dialectical relations between globalization and deglobalization, and possible ways to respond to the challenges of deglobalization. In the meantime, we flesh out these theoretical perspectives using the cases of nationalism, neoliberalism, White supremacy, far-right politics, dehumanization, isolationism, and trade conflicts.
Ensuring universal access: The case for Medicare in prison
Authors: Linnane Damien , McNamara Donna , Toohey Lisa
Published: May 2023

This article makes the case for the provision of Medicare universally to all Australians, specifically to those who are currently incarcerated. As the article explains through its focus on mental health, the exclusion of Medicare from prisons was not part of the original design of the Australian health care system, and its ongoing absence has had dramatic impacts on the human rights and health of those in the criminal justice system.