bluuebunny/crossref_metadata_2025 huggingface dataset:
New evidences about small delphinids stranding in the west Algerian coast
Authors: Dermeche Keltoum , Bentaalla Mohammed El Amine , Bouderbala Mohammed , Boutiba Zitouni
Published: June 2020

The Cetaceans are marine mammals that often get stranded along the Algeri-an coast, due to several factors (parasitism, marine pollution, injuries, acci-dental fishing, etc.). In view of the growing interest in the knowledge of ma-rine mammals stranding, an effort to collect this information in the west Al-gerian coast has been carried out by the Environmental Monitoring Network Laboratory since 80s. The aim of this study is to describe and provide new evidences about the stranding of the small delphinids in the Algerian west-ern coast. The study was conducted on 35 individuals of small delphinids reported stranded and dead on-shore from three districts (Mostaganem, Oran and AinTemouchent). Five different specieshave been identified, in-cluding three frequent common species (D. delphis, S. coeruleoalba, T.truncatus) along with two relatively less frequent species (G. melas, G.griseus). Life history information was gathered in terms of morphometrics and sex. The stranded individuals were small to medium-sized cetaceans, ranging from about 0.6 meter to almost 5 meter in length, with an average languor of 2.25 ±1.01 meter. Aside from undetermined individuals due to advanced decomposition of the carcass, the sex ratio of male vis a vis of fe-male was of 0.78 clearly indicating a female predominance. An assessment of causes of mortality was conducted using different observing indexes. It turns out that the most likely cause of the mortality is attributed to inci-dental human actions by entanglement in fishing gear and ships collisions with small delphinids are a conservation problem of growing concern world-wide. This study improves knowledge on small delphinids stranding through the west Algerian coast and has broad implications in establishing a conser-vation management program.
Potential role for Trichoderma harzianum, Clonostachys rosea and salicylic acid to induce resistance of date palm roots to Bayoud disease (Fusarium oxysporum f. sp. albedinis)
Authors: Sahouli Safia , Sanchez Jose , Gallego Eduardo , El Hadj Khelil Aminata Ould
Published: June 2020

Bayoud disease caused by Fusarium oxysporum f. sp. albedinis (FOA) poses a major problem to date palm (Phoenix dactylifera L.) in Northern Africa. To solve this issue, biocontrol agents and chemicals inducers were used to trigger defense reactions. The present study indicates the direct effect of two antagonistic fungi, Trichoderma harzianum (TH) and Clonostachys rosea (CR), and salicylic acid (SA) application (1 mM, 1.5 mM) in date palm against FOA. Date palm plants were infected by FOA, inoculated with TH or CR, 3 days earlier, or immersed at two SA concentrations (1 mM, 1,5 mM), daily for 3 days. Plants were harvested and examined 3 days after FOA inoculation with pathogen. FOA alone treated plants were led to strong induction of phenylalanine ammonia-lyase (PAL) and peroxidase (POX), all biocontrol treatments showed an increase in chitinase (CHI) and glucanase (GLU) activi-ties. SA 1mM treated plants also showed high levels of lipoxygenase (LOX), SA 1,5 mM treated plants were increased in POX. Histochemical localization of POX activity and lignin content showed that high POX activity was already observed in plants treated with TH and CR. These findings support are useful in understanding the role of two antagonists and inducer abiotic to trigger defense related enzymes in imparting resistance to date palm against FOA.
Role of absorption coefficient on biomaterials
Authors: Rajasekhar E. , Ushasree A. , Prashanthi A. , Mahesh B. , Kumar B. Vijaya , Chittemma B.
Published: June 2020

The study of absorption coefficient of various biomaterials have been an important part of research work in the field of radiation biology. Absorption coefficient has an important parameter for study of interaction of radiation with matter. Biomaterials were nonviable materials used in a material device intended to interact with biological systems. An explicit phenomena related to the gamma ray interaction with biomaterials were reported. Results showed that composite resin had lowest absorption coefficient and Zinc oxide had highest absorption coefficient values. We observed that composite resin biomaterial has lowest absorption coefficient than other investigated materials. The biological shielding material could expect lowest absorption coefficient. The significant role of absorption coefficient on biomaterials shown unique nanoscale morphology of biomaterials. Absorption coefficient of biomaterial increased by reducing the sample thickness at nano scale. This absorption phenomenon indicates the role of the unique biological shielding effects on biomaterials. Enhanced γ-ray biological shielding effects of the biomaterials were ZnO, TiO2 , Dycal (DC) and Composite resin (CR). A statistical analysis of the data using an ANOVA test between the groups was signifi-cant difference between the surface micro hardness of these groups p<0.05. Biomaterials were used in Dentistry in such restorative procedures as dental restorations, dentures, dental implants. Therefore, biomaterials could now be used in the fabrication of light weight biomedical safety equipment such as dental materials and devices. Biomaterials can also be used as a bone sub-stitute and pH-values of the material used for health and therapeutic applications.
Protective effect of Pistacia atlantica Desf leaves on Mercury-Induced toxicity in Rats
Authors: Benahmed Fatiha , Rached Wahiba , Kerroum Fatima , Zohra Belhouari Hayet Fatima , Mehrab El azhari , Talhi Hanene , Belmokhtar Mansouria , Kharoubi Omar
Published: June 2020

Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from the embryo to adulthood. The purpose of the present study was to evaluate the hepatorenal protective effect of natural products such as the aqueous extract of Pistacia atlantica against the toxicity and oxidative stress induced by mercuric chloride in male rats. Adult Wistar rats weighing between 55 and 65 g were randomly assigned to 3 lots. The ani-mals were administered with mercury chloride (HgCl2) intraperitoneally for 32 days. The group intoxicated were administered with 2.5 mg/kg of HgCl2, while the group of treated by HgCl2 and P.atlantica received 2.5 mg/kg of HgCl2 and 150 mg/kg of aqueous extract of P.atlantica. The liver and kidney weight, and marker enzymes (alkaline phosphatase, serum total protein content, urea, uric acid, creatinine, direct and total bilirubin and lipid profile), the metal contents, and histopathological investigation were determinated. The results showed an decrease in levels of biochemical parameters in the serum of animals treated with HgCl2 and P. atlantica. An improvement of liver and kidney functions was also observed. The results showed that ad-ministration of Pistacia atlantica aqueous extract represents a promising candidate for the treatment of liver and renal damages.
Evaluation of the antioxidant activity of phenolic extracts from pomegranate bark (Punica granatum. L)
Authors: Salim Nebbache , Halima Bakhtaoui , Nabila Attala , Ibrahim Dris , Med Ali Bekada Ahmed , Ahmed Latigui
Published: June 2020

Pomegranates (Punica granatum) are among the fruits richest in vitamin C and phenolic compounds, in particular anthocyanins and phenolic acids. Sev-eral types of polyphenols with antioxidant properties are present in different parts of the pomegranate such as the stems and bark. This study aims to evaluate the antioxidant properties of extracts from the barks of P. gran-atum L for their use in the therapeutic and nutritional fields. The extraction of phenolic compounds was made using three solvents namely; methanol, ethanol and acetone. The total polyphenol dosing results revealed the meth-anolic extract’s richness in total phenolic composites with a ratio of about 2.940±0.087g EAG/g of lyophilization resultant extract. Likewise, the etha-nolic extract has shown a high concentration, followed by the acetonic extract, with total content of about 2.699 ± 0.057g EAG/g and 2.306 ± 0.026g EAG/g of lyophilization result extract, respectively. Antioxidant activity meas-ured by free root reduction (DDPH) revealed that the methanolic extract presented the most appropriate DPPH-root-inhibiting activity, with an inhib-iting concentration of 50% (IC50) being equal to 0.68 mg/ml. Moreover, the extracts obtained from the three solvents have shown efficiency compared to ascorbic acid (IC50 equal to 0.714±0.004mg/ml). Considering the antioxi-dant activities, it is recommended that P. granatum be used as a functional ingredient in the food industry and pharmaceutical preparations.
Use of Coco peat for soilless cultivation of tomato
Authors: Malviya N. K. , Chaurasiya R. , Maji S.
Published: June 2020

Soilless cultivation of tomato has been attempted with different growing media in a hydroponic system as roof-top gardening which is very important component of increasing peri urban agriculture. Tomato seedlings were grown under soilless culture supported with various growing media namely- Soil, Vermiculite, Vermicompost, Coco-peat, Perlite, Peat and Compost where as nutrients were supplied through hydroponic system using Hoa-gland solution. The experiment was carried out in pot culture following com-plete randomized design with eight treatments and four replications. The study revealed that use of coco-peat may be good for improvement of vege-tative growth (27.50 maximum branches per plant), fruit yield (1.28 kg per plant) and quality (TSS 5.15oB, total sugars 3.97%, Vitamin C 26.07 mg/100 g fruit, though it was at par with vermiculite 26.52 mg/100 g) followed by peat and compost. It is also evident by good root growth under Hoagland solu-tion. It is clear that among the various media under study coco-peat can be used as a supportive growing media for soilless cultivation of tomato.
Citizen Engagement Challenges in Urban Disaster Management Programs with Special Reference to Fire, Waterlogging and Pandemics
Authors: Kazi Nazmul Huda  , M. Jamir Uddin  , Moslehuddin Chowdhury Khaled
Published: June 2020

The main objective of this study is to explore the challenges of engaging citizens in urban disaster management (UDM) in the urban fire, waterlogging, and pandemic like COVID 19. A qualitative research approach, mainly in-depth interview method was applied to gain insights from different government officials of civil defense, police force, and ward councilors of Dhaka and Chattogram City Corporations, who were experienced in working at the field level UDM. The study tried to investigate the challenges faced by the officials during disaster rescue operations with special reference to the role of urban citizens. The findings of the study capture, in detail, the challenges faced by different personnel involved in UDM operations. While citizen engagement is expected to be a positive notion, in most cases, citizens themselves become the main obstacle of disaster management, due to their ignorance, negligence, and lack of patience in the given disastrous and pandemic situation, and thus, hinders UDM operations and crisis management. The lessons learned from contemporary urban disasters like fire and the COVID 19 pandemic are recorded elaborately. Based on that, different recommendations are made to ensure the active engagement of citizens to facilitate UDM activities in an orderly manner.
Antidiabetic and Antioxidant Effects of Acteoside from Jacaranda mimosifolia Family Biognoniaceae in Streptozotocin–Nicotinamide Induced Diabetes in Rats
Authors: El-Marasy Salma A. , El-Shenawy Siham M. , Moharram Fatma A. , El-Sherbeeny Nagla A.
Published: June 2020

BACKGROUND: Acteoside is a phenylethanoid compound isolated from Jacaranda mimosifolia D. Don leaves with a potential antidiabetic effect.
OBJECTIVES: This study was designed to investigate the antidiabetic and antioxidant effects of acteoside in streptozotocin-nicotinamide (STZ-NA)-induced Type 2 diabetes in rats.
METHODS: Diabetes was induced by intraperitoneal (i.p.) injection of a single dose of STZ (52.5 mg/kg), 15 min following i.p. administration of NA (25 mg/kg). Rats were divided into six groups; Group I: Normal rat group received the vehicle, Group II: Diabetic control group, and Groups III-IV: Diabetic rat groups were treated by either oral acteoside (10, 20, and 40 mg/kg) or pioglitazone (30 mg/kg) for 21 consecutive days. Biochemical parameters were assessed in the serum and liver homogenates. Examination of liver sections for histopathology was also carried out.
RESULTS: Acteoside treated rats showed significant lower levels of blood glucose, glycosylated hemoglobin, total cholesterol, triglycerides, and increased serum insulin compared to control diabetic rats. Furthermore, acteoside treated rats, in comparison to the diabetic control, demonstrated significantly reduced malondialdehyde, increased reduced glutathione liver contents, and attenuated pathological alterations in the liver. These effects were comparable to those caused by the standard antidiabetic drug, pioglitazone. In vitro, acteoside scavenged stable free radical 1,1-diphenyl-2-picrylhydrazyl.
CONCLUSION: Acteoside could be considered as a potential therapeutic agent for type 2 diabetes mellitus. However, studying further mechanisms underlying its antidiabetic effect is recommended.
Polyisoprenoids from Avicennia marina induces on P13k, Akt1, Mammalian target of rapamycin, Egfr, and P53 Gene Expression Using Reverse Transcription-Polymerase Chain Reaction
Authors: Qurrohman Taufiq , Basyuni Mohammad , Hasibuan Poppy Anjelisa Zaitun
Published: June 2020

BACKGROUND: According to the Global Cancer Observatory in 2018, Asia was the first to note the incidence of colon cancer, which was 51.8% of cases of colon cancer which ranked the top three in the number of causes of death in the world. Cancer is a disease characterized by uncontrolled cell growth. Potential natural ingredient developed as chemotherapeutic agents includes from mangrove leaves. Studies reporting on the pharmacological activity of polyisoprenoid from mangrove species are still limited, therefore, it is essential to achieve the prospects, potential, and mechanisms polyisoprenoid in mangroves as a natural ingredient of pharmaceutical and medication.
AIM: The aim of the study was to investigate the inhibition activities of polyisoprenoids in mangrove plant Avicennia marina in WiDr cells induces on P13k, Akt1, mammalian target of rapamycin (mTOR), Egfr, and P53 gene expression using reverse transcription-polymerase chain reaction (RT-PCR).
MATERIAL AND METHODS: The leaves of A. marina were dried and extracted with n-hexane followed by evaporation and freeze-drying. Polyisoprenoid contents were analyzed with two-dimensional thin-layer chromatography method. Cell viability was assessed with 3-(4,5-dimetiltiazol-2-il)-2,5-diphenyl tetrazolium bromide assay. The cycle cell was tested with flow cytometry method. The apoptotic test was determined with a double-staining method. The gene expression on P13k, Akt1, mTOR, Egfr, and P53 was analyzed by RT-PCR method.
RESULTS: The results showed that 48 h cytotoxic activity of polyisoprenoids against WiDr cells and 5-Fu (positive control) had IC50 values, 295.25 μg/mL and 17.43 μg/mL. Cell cycle analysis depicted that the inhibition of polyisoprenoid occurred in the G0-G1 phase and 5-Fu in S phase. Polyisoprenoid and 5-Fu had the same mechanism in the early apoptotic phase. RT-PCR revealed that polyisoprenoids downregulated the P13k, Akt1, mTOR, and Egfr gene expression, and however, upregulated P53 gene expression.
CONCLUSION: The present study confirmed that polyisoprenoids from A. marina leaves showing as chemopreventive agents for colon cancer.
Decreased Expression of Peroxisome Proliferator-activated Receptor α Gene as an Indicator of Metabolic Disorders in Stunting Toddler
Authors: Berawi Khairun Nisa , Maskoen Ani Melani , Akbar Leva
Published: June 2020

BACKGROUND: Stunting in children increases the risk of degenerative diseases in adulthood, including dyslipidemia, obesity, type 2 diabetes mellitus, and cardiovascular disease. This is based on the result of metabolic changes that may be caused by chronic malnutrition and experienced by stunting children. Stunting in children is associated with metabolic disorders that are based on impaired fat oxidation, a trigger factor for obesity in adulthood. The peroxisome proliferator-activated receptor (PPAR) α gene is a transcriptional factor that regulates fat, carbohydrate, and amino acid metabolism whose genetic variants are linked to the development of dyslipidemia and cardiovascular disease.
AIM: The study assessed the effect of metabolic changes in stunting toddler on PPARα gene expression.
MATERIALS AND METHODS: An analytical-observational laboratory was done using 41 blood samples, coming from 23 stunting toddlers, and 18 not-stunting toddlers. In all research subjects, anthropometric measurements and examination of PPARα gene mRNA expression were carried out. Analysis of PPARα gene mRNA expression using one-step quantitative reverse transcriptase-polymerase chain reaction using specific primers, as a comparison of gene expression using the GAPDH gene. The relative expression of the PPARα mRNA gene was analyzed using the LIVAK formula.
RESULTS: The study obtained a mean of ΔCT in stunting toddlers of 5.81, whereas in stunting toddlers at 5.082. Analysis with LIVAK 2 ^ - formula (ΔCT stunting -ΔCT not stunting) obtained PPARα mRNA gene expression of 0.6.
CONCLUSION: We conclude that there is a decrease in PPARα gene expression in stunting toddlers.
Laparoscopic Nephroureterectomy in the Upper Urinary Tract Urothelial Carcinoma with Transvaginal Extraction
Authors: Zulfan Hendri Ahmad , Yuri Prahara , Zulfiqqar Andy , Hashfi Azwar , Soerohardjo Indrawarman
Published: June 2020

BACKGROUND: The upper urinary tract urothelial carcinoma (UTUC) is a rare urological malignancy. Laparoscopic nephroureterectomy (LNU) is one of the options for minimally invasive surgery for UTUC. It has similar oncological outcomes compared to open nephroureterectomy. One of the techniques developed for specimen extraction is the transvaginal route. Transvaginal specimen extraction has advantages in the reduced risk of complications, faster recovery time, and better end result.
CASE PRESENTATION: A 37-year-old woman complained of intermittent pain in her right flank for the past 2 months, with significant weight loss. No other significant symptoms occurred. Her general condition was good with a Karnofsky Performance scale index is 90. In the right periumbilical area, there was a mobile, smooth mass palpated with the size of 10 × 12 cm. There was no tenderness. The patient underwent URS and biopsy of the right ureteral mass with pathological analysis resulting in UTUC. Then, the patient underwent laparoscopic radical nephroureterectomy.
CONCLUSION: Although the surgical procedure was safe for the patient and more effective in terms of less morbidity, faster healing time, and better cosmetic appearance, transvaginal extraction of the kidney needs to be further studied, particularly relating to the little experience of this new technique.
Metastatic Papillary Thyroid Carcinoma Arising in a Neglected Goiter: A Case Report
Authors: Nasir Mohd Zulhilmie Mohd , Peter Alan Basil , Azraai Awla Mohd , Malek Khasnur Abd
Published: June 2020

BACKGROUND: Periodical clinical surveillance for early thyroid cancer detection among patients with diffuse goiter is a common scenario managed in the primary care setting. However, clinical palpation alone is neither sensitive nor specific in detecting the presence of nodules within a goiter. Hence, further investigation with ultrasound is key to effective surveillance for early detection of thyroid cancer.
CASE REPORT: We present a case of a stable diffuse goiter in a 51-year-old woman diagnosed 30 years ago who refused further imaging investigation. Based solely on clinical palpation, the presence of nodules within the goiter was missed. This resulted in transformation into papillary thyroid carcinoma with lung metastases. She presented with progressive hoarseness of voice and cough for 3 months. An ultrasound of the thyroid gland revealed a large heterogeneous nodule in the left lower pole with coarse calcification and internal vascularity. Further imaging with contrast-enhanced computed tomography of the neck and thorax revealed an enhancing nodule in the left thyroid lobe which extends inferiorly to the left retroclavicular region which compresses the trachea causing narrowing of its lumen at T1 and T2 vertebral levels. There were multiple lung nodules in both lungs suggestive of metastases.
CONCLUSION: A total thyroidectomy followed by radioactive iodine thyroid ablation therapy was performed. The histopathological examination revealed the surgical specimen to be papillary thyroid carcinoma.
Dede Korkut Kitabı’nda İktidar ve Toplumsal Cinsiyet İlişkisi Bağlamında Bayındır Han
Authors: UĞURELİ Ayşe
Published: June 2020

Cinsiyet, bireylerin doğuştan sahip
olduğu biyolojik bir özellik iken cinsiyet rolü, toplumsal bağlamda bu
cinsiyete yüklenen anlamsal kodlar olarak tarif edilebilir. Önceleri iş
bölümlerinin kadın ve erkeğin doğasına uygun olarak ayrışması ve üreme odağında
ortaya çıkan cinsiyet rolleri sonraki zamanlarda kalıplaşarak nesilden nesile
aktarılmıştır. Zamanla cinsiyet rolleri bağlamında erkek, güç ve zorluk gerektiren
çoklukla dış mekân işlerini üstlenirken kadın iç mekânda kalmıştır. Dolayısıyla
cinsiyet rollerinin ayrışması aynı zamanda toplumsal yapıların inşa süreçlerini
de etkilemiştir. Erkekliğin asıl cinsiyet olarak belirlendiği ataerkil
toplumlarda toplumsal yapılar erkeklik ile inşa edilmiş, bu durum da
iktidar ve eril cinsiyet ilişkisini
güçlendirmiştir. Dede Korkut Kitabı’nda iktidar olmak savaşçı, düşmanlarına
karşı acımasız, cömert, koruyup kollayan, lider, toplumun her aşamasına her
kurumuna nüfuz eden ve bunları da Tanrı’dan aldığı güç ve yetki ile yerine
getiren demektir ve boylarda iktidarın tüm bu yetkileri Bayındır Han’ın
bünyesinde eril iktidar aracılığıyla hayat bulmuştur. Öyle ki Bayındır Han boylarda
fiilen yer almaz fakat ağırlığı, gücü ve iktidarı ile daima merkezdedir. Bu
çalışmada Dede Korkut Kitabı’nda eril cinsiyet ve iktidar ilişkisi bağlamında
Bayındır Han tartışılmıştır. Oğuz toplumunda cinsiyet ilişkilerinin ve Türk
törelerince idealize edilmiş toplumsal düzenin Bayındır Han iktidarı ile nasıl ve
ne şekilde sağlandığı analiz edilmiştir.
Ömer Seyfettin’in “Yüksek Ökçeler” ve “Nakarat” Hikâyelerinde Mizahi Unsurlar ve Ahlaki Bir Değer Olarak Namus
Authors: TİRYAKİ Zeynep Nur
Published: June 2020

Türk edebiyatında
hikâyenin önemli isimlerinden biri olan Ömer Seyfettin’in hikâyelerinde mizahi
unsurlar yoğun olup onun hikâyelerinde ahlaki bir değer olarak namus kavramı da
geniş bir yer tutmaktadır. Ömer Seyfettin’in hikâyeleri bu anlamda eleştirel
bir ton taşımaktadır. Ömer Seyfettin’in “Yüksek
Ökçeler” ve “Nakarat” hikâyeleri
mizahi unsurlar taşımaları ve bireyler özelinde sosyal eleştiri yapmaları
bakımından öğretici olmakla birlikte iki hikâyenin ortak noktaları mizah ve
namustur. “Yüksek Ökçeler”i
mizahi bir hikâye yapan unsurlar, “Nakarat”ta
kara mizah/trajikomedi biçiminde yer almaktadır. İki hikâyenin bu bağlamda
karşılaştırılması, Ömer Seyfettin’in mizahi yönünü ve bu mizahi yönün ne amaçla
kullanıldığını açıklamaya olanak sağlayacaktır. Bu hikâyelerdeki namus kavramı
ve bu kavramın işleniş biçimi; Ömer Seyfettin’in, hikâyelerinde ahlaki eğitimi
nasıl öne çıkardığını anlamaya yardımcı olacaktır. Bu çalışmanın amacı, Ömer
Seyfettin’in “Yüksek Ökçeler” ve
“Nakarat” hikâyelerinden yola çıkarak yazarın toplumu eğitme/eleştirme
amacıyla yahut safi olarak işlediği mizahi unsurları ve ahlaki bir değer olarak
namus kavramını tespit etmektir. Ömer Seyfettin’in hikâyeciliği böylece,
hikâyeciliğini oluşturan bu en mühim noktalar üzerinden aydınlatılmış
olacaktır.
Abstract Pages
Authors: Editor
Published: June 2020

Abstract Page for all paper who published on Jurnal Penelitian Pers dan Komunikasi Pembangunan Volume 19 No.1 June 2015
Bir Kültürel Direniş Örneği Olarak Kur’an’da Ashab-ı Kehf
Authors: ÇİFTÇİ Merve Betül
Published: June 2020

Geçmişten beri gerek toplumlar gerekse de bireyler birtakım söylemlere ve buyruklara karşı çıkmışlardır. Bu karşı çıkma kimi zaman şiddete dayalı faaliyetler şeklinde olmuş, kimi zaman da şiddetsiz bir direniş olarak kendini göstermiştir. Kültürel direniş de bir şiddetsiz direniş biçimidir. Bu direniş şeklinde gücün kaynağı kültürdür. Kültürler oluşum sürecinde farklı kültürlerle karşılaşırlar. Kimi zaman bu kültürlere ait değerleri kendi potalarında eritip bünyelerine katarlar. Kimi zaman da kendilerini tehlikede hisseder ve o kültüre karşı bir mücadeleye girişirler. Çünkü hiçbir kültür başka bir kültürün baskısı altında ezilmek, yok olmak, kendi değerlerini kaybetmek istemez. İşte bu noktada kültürel direniş kendini göstermektedir. Bu çalışmada kültürel direniş kavramının Kur'ânî iz düşümleri, direnişin en eski örneklerinden olan Ashâb-ı Kehf kıssası üzerinden okunmaya çalışılmıştır. Sonuç olarak Ashâb-ı Kehf'in yapmak istediği şey yeni bir dil üretmek, var olan söylemi silerek huzura ermeyi amaçlayan bir söylemi ikâme etmekti.
Fungsi Instruktif, Konsultatif, Partisipatif dan Delegasi Dalam Melihat Fungsi Kepemimpinan Kepala Desa Kelapapati Kabupaten Bengkalis
Authors: Afrizal Dedy , Saputra Riko , Wahyuni Lilis , Erinaldi Erinaldi
Published: June 2020

Kepala desa di tuntut untuk menjalankan fungsi kepemimpinannya dalam semua  aktivitas pemerintahan desa. Berperan penting dalam merencanakan dan membuat suatu keputusan yang digunakan dalam menjalankan roda pemerintahan. Desa kelapapati dalam pelaksanaannya belum berjalan dengan optimal, temuan observasi iaitu masih rendah kesadaran aparatur desa dan masyarakat dalam melaksanakan perintah yang diberikan kepala desa serta kurangnya kehadiran aparatur, lembaga kemasyarakatan dan masyarakat dalam mengikuti kegiatan Desa. Tujuan penelitian ini melihat fungsi kepemimpinan kepala desa kelapapati dengan melihat fungsi instruktif, konsultatif, partisipatif dan delegasi. Menggunakan pendekatan kuantitatif dengan menyebarkan kuesioner kepada aparatur desa serta unsur-unsur desa yang terlibat. Temuan penelitian tentang pelaksanaan fungsi kepemimpinan didesa Kelapapati adalah cukup baik.
Review Pengaruh Local Strongman Di Provinsi Jambi (Studi Kasus Dominasi Zulkifli Nurdin Terhadap Partai Amanat Nasional)
Authors: Ahmad Zakly , Akbar Aryo , Adlin Adlin
Published: June 2020

Peralihan kekuasaan dari sentralisasi menuju desentralisasi telah banyak mempengaruhi iklim politik setiap daerah di Indonesia, hadirnya orang kuat lokal merupakan hal yang sedang mewabah di negara demokrasi. Dinamika yang terjadi mengakibatkan adanya dominasi ekonomi dan politik yang berimbas pada kehidupan demokrasi. Penelitian ini menggunakan pendekatan studi literatur dengan teknik pengumpulan data yang berasal dari berita online, buku dan penelitian yang berkaitan dengan pembahasan. Penelitian ini memiliki tujuan untuk mengeksplorasi dan mendalami bagaimana Peran Zulkifli Nurdin dalam membuat polarisasi Partai Amanat Nasional di Provinsi Jambi hingga mempertahankan citranya sebagai orang kuat lokal. Dominasi Zulkifli Nurdin berhasil membuat Partai Amanat Nasional sebagai alat untuk membentuk dinasti politiknya di Jambi, hal ini terbutki dari petinggi di Partai Amanat Nasional hanya terdiri dari keluarga dan kroni – kroninya saja.
Review Penyediaan Sistem Informasi Menejemen Pegawai Pada Badan Kepegawaian Dan Pengembangan Sumber Daya Manusia Kota Pekanbaru Dalam Mendukung Kebijakan E-Government Pada Tahun 2019
Authors: Darmansyah Ramlan , Handoko Tito , Tiyas Tinov Mohammad Yohamzy
Published: June 2020

Kebijakan E-Government adalah untuk mengurangi penggunaan sistem manual atau penggunaan kertasdalam layanan apapun. Adanya kebijakan teknologi informasi dalam lingkungan pemerintah diharapkandapat mewujudkan e-Government yang transparan dan efisien. Tujuan dari penelitian ini adalah 1). Untukmengetahui penyediaan sistem informasi manajemen Officer pada personil badan dan pengembangansumber daya manusia Pekanbaru dalam mendukung kebijakan e-Government pada tahun 2019 dan 2.)Mengetahui faktor pendukung yang memberikan informasi kepada petugas manajemen sistem pada badanpersonalia dan pengembangan sumber daya manusia Pekanbaru City dalam mendukung kebijakan e-Government pada tahun 2019. Metode yang digunakan dalam studi ini menggunakan pendekatankualitatif, jenis penelitian adalah studi literatur di mana sumber data yang Diperoleh dari produk hukum,jurnal artikel, dokumen terkait dan sumber media massa. Penelitian dilakukan pada badan personalia danpengembangan SDM. Hasil dari penelitian ini adalah penerapan program manajemen sistem informasiyang diimplementasikan oleh badan personalia dan pengembangan sumber daya manusia selainmewujudkan pemerintah berbasis e-Government juga mendukung kebijakan Walikota Pekanbaru.Adanya dukungan e-Government dalam penyediaan sistem informasi manajemen staff di badanpersonalia dan pengembangan sumber daya manusia Kota Pekanbaru.
Correlation study of relative parameters of intracranial pressure and prognosis of patient with craniocerebral injury
Authors: Liu Laixing , Deng Yixin , Liu Fuquan , Chen Lei , Li Dexi , Wang Xiangyi
Published: June 2020

Objective: To analyze the correlation of the relative parameters of intracranial pressure to the prognosis in patients with craniocerebral injury.Methods: The clinical data of 80 patients with closed craniocerebral injury were retrospectively analyzed, and all of these patients underwent conventional examinations of arterial blood pressure and intracranial pressure. Neumatic DCR system was used to monitor relative parameters of intracranial pressure from patients. According to the score of Glasgow outcome scale (GOS) upon discharge, they were divided into favorable prognosis group (GOS III-V, n = 46) and unfavorable prognosis group (GOS I-II, n = 34). The relative parameters of intracranial pressure of two groups were compared so as to analyze the correlation of the prognosis in patients to ICP-related parameters.Results: Pressure reactivity index (PRx) and intracranial pressure (ICP) of favorable prognosis group were significantly higher than those of unfavorable prognosis group (t = 12.27, t = 5.22, p < .05). Meanwhile, cerebral perfusion pressure (CPP) and ICP-ABP wave amplitude correlation (IAAC) of favorable prognosis group were significantly lower than those of unfavorable prognosis group (t = 14.54, t = 14.78, p < .05). The average age, gender, duration of admission to neurosurgical intensive care unit (NICU) and GCS (Glasgow coma scale) score on admission of the two groups were not statistically significant.Conclusions: The prognosis and ICP-related parameters (such as PRx, ICP, CPP, etc.) in patients with craniocerebral injury are risk factors for the prognosis effect. Therefore, to monitor the above-mentioned indicators has an important clinical value for assessing the prognosis of craniocerebral injury.
A Tribute to Professor Jan Szargut 09.09.1923 – 21.11.2017
Authors: Editors Board Of
Published: June 2020

Please read the full text.
Everyday Life Emotions during Anti-Fugitive Offenders Ordinance Protests in Hong Kong
Authors: Ma Tsz Wah
Published: June 2020

This experience sampling study investigated the impact of political movement (i.e. Anti-Fugitive Offenders Ordinance Protests) on everyday emotional reactivity and dynamics. Participants who finished our experience sampling during Movement (18–70 years; n = 100) and matched sample (18–70 years; n = 100) reported positive and negative emotions seven times a week for five weeks. Hierarchical linear modeling revealed that during the Movement, participants reported lower positive emotions and higher negative emotions, and lower positive emotional inertia and higher nega - tive emotional inertia. This study is the first of its kind to investigate different aspects of everyday emotional experiences during political movements. Participants perceived significant changes in their everyday events although the Movement was not long and not severely violent. This study highlights the importance of investigating everyday emotions of people in other more serious conflict and post-conflict settings.
Dietary Intake and Body Composition Characteristics of National Football League Players
Authors: Afrifa Daniel , Nsiah Kwabena , Appiah Collins Afriyie , Moses Omoniyi Monday
Published: June 2020

Background: It has been well documented that adequate body composition characteristics and good nutrition practices play significant roles in maintaining good health, proper immune functioning, muscle growth and repair, and delaying fatigue in continuously intense athletic performance. It would be incumbent, however, to support imported information with local data to enhance effective implementation. Objectives: To examine dietary intake and body composition characteristics of National Football League Players in the Ashanti region of Ghana. Methods: Cross-sectional study was used. 95 football players from the premier, 1st and 2nd divisions of the Ghana National Football League were recruited. A 24-hour dietary recall was used to assess the dietary intake of the players. Body composition characteristics of body mass index, percentage (%) body fat, visceral fat and percentage (%) muscle mass were measured. Results: There were 8 (9.3%) goalkeepers, 29 (33.7%) defenders, 34 (39.5%) midfielders and 15 (17.4%) strikers. 42 (44.2%) of the players ate twice per day. Players within age group of 20 - 25 (49, 51.6%) had the highest mean total energy intake (2342.96 ± 848.18), carbohydrates (324.18 ± 106.35), proteins (75.54 ± 23.94) and fats (83.00 ± 50.76). Midfield players had the highest mean total energy intake (2216.26 ± 803.87), carbohydrates (315.74 ± 121.02), proteins (74.23 ± 26.35) and fats (71.59 ± 34.32). 82 (86.3%) had normal weight, 79 (83.2%) normal % body fat, 45 (47.4%) had very high % muscle mass. Conclusions: The sample in this study has low total energy intake compared to other studies. Insufficient nutritional diets could suggest the reason for the low energy intake. If low energy intake persists, the players might be at high risk of chronic cardiovascular diseases and diabetes conditions.
Ondansetron Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder: A Randomized Placebo-Controlled Clinical Trial
Authors: Sepehrmanesh Zahra , Adel Mehdi , Ahmadvand Afshin , Sehat Mojtaba
Published: June 2020

Background: Serotonin and dopamine are involved in the development of obsessive-compulsive disorder (OCD). Approximately 40% of OCD patients do not respond to the first-line therapy of treatment using selective serotonin reuptake inhibitors. Reportedly, the response to the treatment is increased by enhancing dopamine blockers. Objectives: The purpose of this study was to evaluate the efficacy and immunogenicity of ondansetron as a booster in the treatment of OCD patients. Methods: The present double-blind, randomized clinical trial (RCT) was conducted on 40 patients (16 males and 24 females) aged 18 to 60 years who met the DSM-V-TR-based OCD diagnostic criteria and had a minimum score of 16 on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The patients were randomized to receive standard treatment and ondansetron (8 mg/day) or placebo for 12 weeks. They were examined using Y-BOCS and side-effect checklist at baseline, fourth, eighth, and twelfth weeks. Results: The patients in both groups were homogeneous and comparable in terms of age, marital sex status, type of obsession, anxiety, depression, age at the onset of disease, and the duration of disease. The Y-BOCS scores in the intervention and placebo groups were 27.15 ± 3.94 vs. 26.15 ± 4.94 at baseline, 25.40 ± 3.75 vs. 25.00 ± 4.79 in the fourth week, 20.85 ± 3.69 vs. 24.05 ± 4.97 (P = 0.026) in the eighth week, and 17.95 ± 3.43 vs. 21.65 ± 4.85 (P = 0.008) in the twelfth week, respectively. Significant changes occurred between the two groups at weeks 8 and 12; the difference between the two groups was significant (P = 0.015), whereas no significant difference was observed between the two groups before week 8. Conclusions: This 12-week, double-blind, and randomized clinical trial showed that ondansetron was a booster agent with a significant effect on patients with moderate to severe OCD. This study also showed that ondansetron is generally well tolerated by OCD patients. The response to the treatment also increased from the eighth week of treatment onwards. The severity of the disease was decreased at the end of the ondansetron intervention. The adjunct ondansetron treatment was recommended for OCD patients
Animal Agora
Authors: Donaldson Sue ,   Department of Philosophy, Florida State University
Published: June 2020

Many theorists of the ‘political turn’ in animal rights theory emphasize the need for animals’ interests to be considered in political decision-making processes, but deny that this requires self-representation and participation by animals themselves. I argue that participation by domesticated animals in co-authoring our shared world is indeed required, and explore two ways to proceed: 1) by enabling animal voice within the existing geography of human-animal roles and relationships; and 2) by freeing animals into a revitalized public commons (‘animal agora’) where citizens encounter one another in spontaneous, unpredictable encounters in spaces that they can re-shape together.
Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide
Authors: Kiso Yoshiaki , Kitagawa Kouki , Nobuyuki Kawai , Akita Tadashi , Takagi Hiroshi , Amano Hiroo , Fukui Kiyoshi
Published: July 2002

The amino acid sequence of a newly isolated pentapeptide, neo‐kyotorphin from bovine brain was synthetically verified to be Thr‐Ser‐Lys‐Tyr‐Arg corresponding to the C‐terminal portion of hemoglobin α‐chain. The synthetic neo‐kyotorphin showed the dose‐dependent analgesia in mice which was approximately equal to that of Leu‐enkephalin.
The use of 4‐methylumbelliferyl and other chromophoric glycosides in the study of cellulolytic enzymes
Authors: van Tilbeurgh Herman , Claeyssens Marc , de Bruyne Clement K.
Published: July 2002

HPLC‐analysis of the reaction products of a series of 4‐methylumbelliferyl glycosides from cello‐oligosaccharides, used as substrates of a cellobiohydrolase from Trichoderma reesei, proves the lack of specificity for terminal cellobiosyl groups. Also, different reaction patterns are observed for this CBHI and for an endocellulase, when acting on these same substrates. 4‐Methylumbelliferyl β‐D‐lactoside is an unexpected substrate for CBHI, yielding only lactose and phenol as reaction products. The binding characteristics of p‐nitrobenzyl 1‐thio‐β‐D‐lactoside for this enzyme are determined by a dia‐filtration technique, yielding 1 binding site and an association constant of 4.0 × 104 M−1.
Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle
Authors: Picton Colin , Woodgett James , Hemmings Brian , Cohen Philip
Published: July 2002

Glycogen synthase kinase‐5 (casein kinase‐II) phosphorylates glycogen synthase on a serine termed site 5. This residue is just C‐terminal to the 3 serines phosphorylated by glycogen synthase kinase‐3, which are critical for the hormonal regulation of glycogen synthase in vivo. Although phosphorylation of site 5 does not affect the catalytic activity, it is demonstrated that this modification is a prerequisite for phosphorylation by glycogen synthase kinase‐3. Since site 5 is almost fully phosphorylated in vivo under all conditions, the role of glycogen synthase kinase‐5 would appear to be a novel one in forming the recognition site for another protein kinase
Stoichiometry of the H+‐ATPase of Escherichia coli cells during anaerobic growth
Authors: Kashket Eva R.
Published: July 2002

The H+/ATP stoichiometry of the H+‐ATPase was investigated in Escherichia coli cells growing under anaerobic conditions at pH 6 and 7. The protonmotive force was determined from the intracellular accumulation of benzoate and tetraphenylphosphonium ions, as well as the accumulation of lactose in this lac operon inducible, but β‐galactosidase negative strain. The phosphorylation potential was calculated from the cellular concentrations of ATP, ADP and inorganic phosphate. By comparing the phosphorylation potential and the proton motive force under these steady state conditions, the H+/ATP stoichiometry was determined to be 3, similar to the value previously found in the same cells growing under aerobic conditions.
Structural study of translating 70 S ribosomes from Escherichia coli
Authors: Vasiliev V.D. , Selivanova O.M. , Baranov V.I. , Spirin A.S.
Published: July 2002

Translating 70 S ribosomes of Escherichia coli either in the pre‐translocation or in the post‐translocation state have been prepared by using the cell‐free translation system in poly(U)—S—S—Sepharose columns [Methods Enzymol. (1979) 59, 382–398]. Electron microscopy study of the preparations has demonstrated that: (1) the mutual orientation of the ribosomal subunits in the translating ribosomes is the same as proposed by Lake for routine 30 S·50 S couples [J. Mol. Biol. (1976) 105, 111–130]; (2) the L7/L12 stalk of the 50 S subunit sticks out from the 70 S particle and does not join the 30 S subunit; (3) pre‐translocation and post‐translocation state ribosomes do not differ in mutual orientation of the subunits and in the position of the L7/L12 stalk, within the limits of electron microscopy resolution.
Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site
Authors: Bigay Joëlle , Deterre Philippe , Pfister Claude , Chabre Marc
Published: July 2002

Fluoride activation of the cGMP cascade of vision requires the presence of aluminum, and is shown to be mediated by the binding of one AlF‐4 to the GDP/GTP‐binding subunit of transducin. The presence of GDP in the site is required: AlF4
− is ineffective when the site is empty or when GDPßS is substituted for GDP. This sensitivity to the sulfur of GDPßS suggests that AlF4
− is in contact with the GDP. Striking structural similarities between AlF4
− and PO4
−1 lead us to propose that AlF4
− mimics the role of the γ‐phosphate of GTP.
Glyceraldehyde‐3‐phosphate dehydrogenase is one of the three major RNA‐binding proteins of rabbit reticulocytes
Authors: Ryazanov Alexei G.
Published: July 2002

One of the 3 major RNA‐binding proteins of rabbit reticulocytes, a polypeptide of 36 kDa, is identified as glyceraldehyde‐3‐phosphate dehydrogenase (GAPD). This fact was deduced from the identity of molecular masses, one‐dimensional peptide maps and isoelectric points of the 36 kDa protein and GAPD from rabbit muscle. It is concluded that GAPD can bind rather unspecifically different RNAs and polynucleotides. This means that GAPD, like other RNA‐binding proteins, can form loose dynamic complexes with polyribosomes. Association of such a kind may be used for compartmentation of glycolysis near polyribosomes.
Plasmid‐encoded initiation protein is required for activity at all three origins of plasmid R6K DNA replication in vitro
Authors: Inuzuka Manabu
Published: July 2002

DNA replication of plasmid R6K initiates at three unique sites, oriα, oriβ and oriγ. Replicating DNA molecules of a deletion derivative of R6K were synthesized in an in vitro system containing π protein fraction from cells carrying a mini‐R6K derivative that produced only this initiation protein as an R6K‐encoded protein and analyzed by electron miscroscopy. Requirement of π protein for the activity of all these three replication origins in vitro was verified. Frequencies of initiation at the three origins were almost equal.
Transient high‐affinity binding of agonists to α1‐adrenergic receptors of intact liver cells
Authors: Schwarz Kurt R. , Lanier Stephen M. , Carter Edward A. , Graham Robert M. , Homey Charles J.
Published: July 2002

At α1‐adrenergic receptors in isolated rat liver parenchymal cells, (−)‐epinephrine is potent in eliciting a maximal increase in glycogenolysis (K
act = 24 nM). This contrasts with a 100‐fold lower affinity for the agonist at α1‐adrenergic receptors of intact hepatocytes determined from equilibrium competition assays with the α1‐adrenergic antagonist [3H]prazosin. We demonstrate here that agonists bind to α1‐adrenergic receptors of intact liver cells initially with a markedly higher affinity than under equilibrium conditions. When incubations are performed for 15 s at 37°C, the affinity is more than 100‐fold higher than that obtained in equilibrium (45 min) assays (IC50 = 28 ± 3 vs 5300 + 400 nM for (−)‐epinephrine and 32 ± 3 vs 6100 ± 500 nM for (−)‐norepinephrine). When incubations are performed at 4°C (150 min), high‐affinity binding similar to that obtained In short‐term incubations can also be demonstrated. In contrast, antagonist compete with similar affinities in 15 s and 45 min assays, and their dissociation constants are not affected by changes in the incubation temperature. These results indicate that agonists bind to native α‐adrenergic receptors transiently with high affinity. The conversion of receptors to a state of predominantly low affinity for agonists, which occurs rapidly and irreversibly with increasing incubation at 37°C, is inhibited at low incubation temperatures. It is suggested that the high‐affinity configuration of the α1‐adrenergic receptor for agonists observed in nonequilibrium experiments or at reduced incubation temperatures represents the physiologically relevant state of the α1‐adrenergic receptor.
Domain structure of human α2‐macroglobulin
Authors: Sottrup-Jensen Lars , Gliemann Jørgen , Van Leuven Fred
Published: July 2002

Digestion of methylamine‐treated α2‐macroglobulin (α2M·MA) with catalytic amounts of papain at pH 4.5 has been investigated. Cleavage of Lys(1313)‐Glu resulted in two major products, which could be separated by gel chromatograhy: a large disulfide bridged fragment set nearly the size of intact α2M·MA, and an 18 kDa fragment, constituting the carboxy‐terminal domain of α2M. This domain contained the receptor recognition site, exposed as a result of cleavage of the internal β‐cysteinyl‐γ‐glutamyl thiol esters in α2M. Compared with α2M‐trypsin complex the apparent affinity for binding to rat hepatocyte receptors was 0.1 and 2% at 4 and 37°C, respectively. The receptor‐binding domain presumably forms a compact globular β‐barrel‐type structure, stable at pH 2.5–9.0. Chemical modification experiments suggest that receptor binding is contributed by a determinant formed by the precise folding of the polypeptide chain.
Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence
Authors: Kubo Tai , Maeda Akito , Sugimoto Katsunori , Akiba Isamu , Mikami Atsushi , Takahashi Hideo , Haga Tatsuya , Haga Kazuko , Ichiyama Arata , Kangawa Kenji , Matsuo Hisayuki , Hirose Tadaaki , Numa Shosaku
Published: July 2002

The complete amino acid sequence of the porcine cardiac muscarinic acetylcholine receptor has been deduced by cloning and sequencing the cDNA. The tissue location of the RNA hybridizing with the cDNA suggests that this muscarinic receptor species represents the M2 subtype.
Kinetics of association and dissociation of colchicine‐tubulin complex from brain and renal tubulin Evidence for the existence of multiple isotypes of tubulin in brain with differential affinity to colchicine
Authors: Banerjee Asok , Luduena Richard F.
Published: July 2002

The kinetics of colchicine binding to bovine brain tubulin have been reported to be biphasic under pseudo first order conditions [(1978) Biochemistry 17, 4466‐4472]. Unlike brain tubulin, the kinetics of colchicine binding to bovine renal tubulin are monophasic. The apparent on‐rate constant for the binding of colchicine to renal tubulin is found to be very close to that of the faster binding component in brain tubulin. Similarly, the dissociation of colchicine‐tubulin complex in the presence of iodide is biphasic for brain tubulin but monophasic for renal tubulin. Since brain and renal tubulin apparently differ in β‐tubulin, our results suggest that the biphasic nature of the kinetics for bovine brain tubulin could possibly originate from the existence of multiple isotypes of tubulin differing in drug binding affinity.