bluuebunny/crossref_metadata_2025 huggingface dataset:
Trastuzumab Deruxtecan (Enhertu)
Authors: CADTH
Published: July 2023

CADTH recommends that Enhertu be reimbursed by public drug plans for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer if certain conditions are met.

Enhertu should only be covered to treat adult patients with HER2-low breast cancer that is unresectable (cannot be removed by surgery) or metastatic (has spread to other parts of the body) who have received a prior chemotherapy for metastatic disease or had their cancer come back after surgery within 6 months of completing adjuvant chemotherapy. If the patient is hormone receptor (HR)-positive, they should have been treated with at least 1 endocrine therapy (ET) and no longer be considered candidates for further ET treatment. Patients receiving Enhertu should be in relatively good health (i.e., have a good performance status, as determined by a specialist). Patients in whom the cancer has spread to the brain or spinal cord, for whom there is spinal cord compression causing symptoms, or those with interstitial lung disease or pneumonitis should not be eligible for coverage.

Enhertu should only be reimbursed if prescribed by clinicians with experience and expertise in treating advanced breast cancer in centres, if it is not used with other cancer treatments, and if the cost of Enhertu is reduced. Patients who experience disease progression while taking Enhertu or who cannot tolerate the drug would not be eligible for continued coverage.
Cryopyrin-associated periodic syndrome Muckle — Wells: A Case Report
Authors: Shakhova N. V. , Burenkina V. V.
Published: July 2023

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An Analysis of the Phenomenon of "Collapsing Persona" of Chinese Celebrities through Goffman's Dramaturgical Theory
Authors: Wang Zi
Published: July 2023

In the current context of the rapid development of China's entertainment industry, the creation of a popular celebrity "persona" has become a shortcut for celebrities and their agencies to gain benefits, and celebrities can quickly gain attention and a large number of fans by constructing a "persona". However, with the rapid development of the Internet, the real face behind the celebrity's "persona" is gradually exposed to the public, and the collapse of the celebrity's "persona" is a common occurrence. The phenomenon of the collapse of celebrity "persona" has serious implications at the personal, interactive and social levels, and the communication and sociological logic and issues behind it are worth exploring and reflecting on. Therefore, this paper analyses the causes of the phenomenon and its negative effects from the perspective of Goffman's mimesis theory and makes suggestions and reflections on how to avoid the negative effects brought about by the collapse of celebrities' "personas". The study found that the collapse of celebrities' "persona" was caused by capital guidance from agencies, the uneven quality of the celebrities themselves, the rapid development of the Internet, the alienation of symbolic consumption, and the addition of fan groups to the drama class. The collapse of a celebrity's "persona" will in turn have a negative impact on these factors, not only affecting the circulation and reproduction of capital, but also deeply affecting the role perception and cultural identity of fans and society at large, fostering a negative social climate and hindering social progress and development. Therefore, in order to eliminate this phenomenon, the entire drama class needs to work together, with stars, agencies, the media, the public, especially fans and the government, and other rights holders sharing their respective social responsibilities to build a good entertainment culture and a healthy popular culture.
Prevalência de distúrbios osteomusculares relacionados ao trabalho em agricultores do oeste do Paraná
Authors: Vendrame Flávia Daniele , El Hajjar Nabil , Souza Isabel Fernandes de , Mombelli Mônica Augusta , Lopes Anália Rosário
Published: July 2023

Os distúrbios osteomusculares relacionados ao trabalho (DORT) podem afetar articulações, músculos, tendões, ligamentos e nervos periféricos e são comuns na agricultura devido à sobrecarga de trabalho, esforços excessivos e repetitivos e adoção de posturas inadequadas para a realização das atividades. O objetivo desse estudo é apresentar a prevalência de DORT, a intensidade e características da dor, além de descrever as categorias e ferramentas de trabalho de agricultores da região oeste do Paraná. Foi realizado um estudo observacional transversal com uma amostra representativa dos agricultores associados ao sindicato da região. Para coleta de dados utilizou-se um questionário sociodemográfico, um formulário sobre categorias e ferramentas de trabalho, a escala visual analógica de dor, o questionário nórdico de sintomas osteomusculares e o McGill para caracterização da dor. Participaram do estudo 144 agricultores, com predomínio do sexo masculino (63,89%) e faixa etária entre 18 e 47 anos (73,61%). A prevalência de DORT nos agricultores foi de 100% e, as regiões mais acometidas foram a parte inferior e superior das costas com (59,72%) e (43,75%) respectivamente. A intensidade da dor foi moderada em 50,69% e do tipo enjoada em 89,58% dos participantes. A atividade de cultivo de grãos está presente em 57,64% dos indivíduos e o uso de motosserra e maquinário agrícola foram as ferramentas mais citadas durante o labor. Os achados apontam a necessidade urgente de intervenção terapêutica e preventiva aos trabalhadores e contribuem ao avanço científico da área. Além de tratar os DORT, mostra-se imprescindível adaptações ergonômicas no trabalho dos agricultores.
New Educational Technologies as a Pledge to Promote Lifelong Learning
Authors: Poghosyan Gayane , Gasparyan Anahit , Grigoryan Meri , Amiryan Yelena
Published: July 2023

Lifelong Learning implies that a person needs to learn continuously in order to enhance knowledge, skills, abilities and competencies. Learning should be implemented for the whole life span not only through natural communication or life experiences, but also benefiting from a variety of conscious educational opportunities, including new technologies. Along with formal, non-formal and informal education, the priority is given to the implementation of modern educational technologies and strategies – transition from passive to active learning, as well as to the introduction of informational technologies in the education process.
Ցկյանս կրթությունը ենթադրում է, որ անձը անհրաժեշտություն ունի շարունակաբար սովորելու և ընդլայնելու ձեռք բերած գիտելիքները, հմտությունները և կարողությունները: Ողջ կյանքի ընթացքում այն իրականացվում է ոչ միայն բնական հաղորդակցության, կենսափորձի, այլ նաև շարունակաբար գիտակցված բազմազան կրթական, այդ թվում՝ նաև նոր տեխնոլոգիաների հնարավորություններից օգտվելու միջոցով: Ֆորմալ, ոչ ֆորմալ և ինֆորմալ կրթություն իրականացնելիս առաջնահերթ է արդի կրթական տեխնոլոգիաների ու ռազմավարությունների կիրառումը՝ պասիվ ուսուցումից ակտիվ ուսուցման անցնելը, ուսումնառության գործընթացում ժամանակի պահանջով նաև տեղեկատվահաղորդակցային տեխնոլոգիաների ներդրումը:
Обучение на протяжении всей жизни подразумевает, что человеку необходимо постоянно учиться и расширять знания, навыки, умения и компетенции. На протяжении всей жизни оно осуществляется не только через естественное общение, жизненный опыт, но и через постоянное использование осознанных разнообразных образовательных возможностей, в том числе новых технологий. При реализации формального, неформального и информального образования приоритетным является использование современных образовательных технологий и стратегий: переход от пассивного обучения к активному обучению, а также внедрение информационно- коммуникационных технологий в учебный процесс.
Capital Expenditure and Future Firm Performance: Evidence from Firms Listed on the Stock Exchange of Thailand
Authors: Thomya Wanlapa , Likitwongkajon Napaporn , Rangsungnoen Grid
Published: July 2023

Abstract: Purpose – Capital expenditure reflects a company's investment in long-term assets expected to generate value for shareholders over time. Such expenses mostly expect to improve a company's future performance. This research aims to explore the relationship between capital expenditure and future firm performance. Design/methodology/approach –A sample (n=475) of registered companies listed on the stock exchange of Thai (SET) from 2000-2016 was selected. The time period selected for this research allows the researchers to analyze the relationship during the period of economic growth and stability. Secondary data was harvested from the Thomson Reuters Datastream database. Findings – A regression analysis showed a negative relationship between capital expenditure and future firm performance, as measured by return on assets (ROA) and dividends. Notably, this negative relationship was found to be statistically significant across the board, first for all companies and second for a unique subset of larger companies. Originality/value - Such findings go against general expectations. Subsequently, the study has implications for general practice, investment, and the academe.In particular, it sheds light on the potential impact of agency on investment expenses. Practically, registered SET companies can use this insight to make informed investment decisions; investors to make investment decisions, and lenders to make lending decisions. Overall, this research provides value for various stakeholders across financial exchanges.
Formulation and evaluation of topical piroxicam microemulgel for arthritis
Authors: Mehreen Sattar  , Somia Sarfraz  , Uzma Liaquat  , Iqra Shoukat  , Bilal Ahmad  , Talib Hussain
Published: July 2023

Background: Piroxicam is an anti-inflammatory, analgesic, and antipyretic drug. Piroxicam is widely used in the management of chronic pain. The objective of this work was to develop and analyze topical Piroxicam microemulgel to improve drug solubility, enhance permeation, reduce GIT side effects reduce the frequency of the drug. Method: The Piroxicam microemulgel was prepared by drawing the pseudo ternary phase picture and water titration procedure.  Formulation was prepared by using isopropyl myristate as an oil, Tween 80 as an surfactant, n-butanol as Co-surfactant and water. It was converted to gel by using 1% Carbopol 940 and few drops of ethanolamine. The prepared formulation was characterized for thermodynamic stability, pH, droplet size, viscosity, FTIR,DSC, electrical conductivity, dye solubility drug content, and in-vitro release using a Franz diffusion cell. Result: Microemulgel formulation was thermodynamically stable on visual inspection after being treated with a freeze-thaw cycle and centrifugation. pH of formulation was 6.5. The mean droplet size for ME gel was 100±0.472nm. The viscosity of the microemulgel was 90.4±0.01 cps which showed Newtonian flow. FTIR and DSC studies showed that microemulgel was compatible with its excipients. Electrical conductivity and dye solubility testing confirmed that the microemulgel was O/W. Piroxicam microemulsion gel showed 89.89% drug content and the release rate of piroxicam was 98±8.63% after 48h. It followed the Korsmeyer Pappas model which means it was a hydrogel-based system. Conclusion: Microemulsion gel formulation obtained remarkably inflated skin retention for piroxicam over the piroxicam gel. It might act as a promising vehicle for the topical delivery of poor water-soluble drugs.
Evolving Paradigms in Laboratory Biomarkers of Fibrinolysis Phenotypes and Association with Post-Traumatic Vascular Thrombosis
Authors: Ogweno Gordon , Kimathi Murungi Edwin
Published: July 2023

Traumatic tissue injury triggers blood coagulation to stanch bleeding and concomitant blood clot lysis to restore vascular patency. Approximately, 40% of trauma cases potentially present with trauma-induced coagulopathy that may coexist with clot dissolution or fibrinolysis. Laboratory test results of fibrinolysis biomarkers stratify fibrinolytic phenotypes into hyperfibrinolysis, physiological, hypofibrinolysis, and fibrinolytic shutdown. However, often, there is incongruence between laboratory findings and clinical presentation of bleeding or vascular thrombosis. Increasingly, it is becoming clear that laboratory findings transiently depend on the timing of blood sampling. The spectrum of evolving fibrinolysis phenotypes, a component of nature’s adaptation to wound healing that ranges from initial promotion of blood fluidity to subsequent thrombosis, presents a clinical diagnostic dilemma with regard to the timing of antifibrinolytics or anticoagulants intervention. This chapter will review the available literature on post-traumatic fibrinolytic phenotypes, diagnostic challenges, evolution over time, clinical outcomes following therapeutic interventions, and association with vascular thrombosis.
Acute Focal Bacterial Nephritis in a Patient with Solitary Kidney: Case Report
Authors: Guella Adnane , Muhammad Rabab Zaka , Aljallabi Mahdi , Mursi Abeer , Elmahi Mohamed
Published: July 2023

Introduction: Acute focal bacterial nephritis is an underdiagnosed condition. It clinically resembles acute pyelonephritis. If unrecognized and undertreated, it may progress into complications (kidney abscess and scars). Contrast-enhanced computed tomography (CT) reveals specific images of the disease and is considered the gold standard to make the diagnosis. Case Report: A 63-year-old male patient with solitary kidney presented with symptoms compatible with acute pyelonephritis. Kidney ultrasound was not conclusive. Because of persisting high-grade fever not resolving after 48 hours of antibiotics, a contrast-enhanced CT was then performed, and the diagnosis of acute focal bacterial nephritis was made. A repeat CT after three weeks of intravenous (IV) antibiotics showed marked improvement of the intrarenal lesions, and a fourth week of IV antibiotics was dispensed.Conclusion: Diagnosing acute focal bacterial nephritis is important (particularly in a patient with solitary kidney). This will dictate the therapy duration. Unlike acute pyelonephritis, acute focal bacterial nephritis requires at least three weeks duration of antibiotics to avoid progress into further complications. 
The developing of motivation for a healthy lifestyle for pupils
Authors: Blindul Mihaela
Published: July 2023

The article addresses the dimension of motivation for developing healthy lifestyles in students. Motivation is for-med by a combination of different factors, including: needs and desires, goals, rewards and punishments, emotions, personal values, social influence. Intrinsic motivation is the basis for the formation and development of a healthy lifestyle and the achievement of desired, long-term results. Thus, motivation plays a key role in maintaining interest in learning and exploration by managing and regulating effort, even when obstacles arise. This requires strong aware-ness, willpower and perseverance. Therefore an important aspect in the context of adopting a health-focused lifestyle is the formation and development of motivation, as an essential foundation for achieving goals
Edad materna avanzada como factor de riesgo de complicaciones obstetricia en pacientes atendidas en servicio de obstetricia del hospital nacional dos de mayo, periodo 2018, Lima-Perú
Authors:   , Escriba Gomez Pamela Abigail
Published: July 2023

OBJETIVOS: El objetivo es determinar la edad materna avanzada como factor de riesgo de complicaciones obstétricas. MATERIALES Y MÉTODOS: Se efectuó una investigación analítica, longitudinal, retrospectiva, observacional, con un nivel de investigación de tipo correlacional en el Hospital Nacional Dos de Mayo en el año 2018. La población de estudio fueron todas las gestantes que se atendieron en el periodo mencionado. La muestra lo conformaron las gestantes añosas (grupo expuesto de 140 pacientes) y gestantes entre 20 y 34 años (grupo no expuesto de 140 pacientes). Se empleó el Chi-cuadrado para establecer la asociación (con nivel de confianza del 95%) y el Riesgo relativo como asociación, muestreo no probabilístico por conveniencia. RESULTADOS: Entre los resultados se halló la edad materna avanzada no mostró asociación significativa con las complicaciones obstétricas como la diabetes gestacional, parto pretérmino y preeclampsia. De otro lado se encontró la edad materna avanzada fue un factor protector para placenta previa (RR=0.40; p=0.041; IC95%: 0.16 – 1.00). CONCLUSIONES: Se concluye que la edad materna avanzada no es un factor de riesgo para la diabetes gestacional, preeclampsia y parto pretérmino; no obstante, la edad avanzada se consideró factor protector para placenta previa con significancia estadística.
Frecuencia e indicaciones de las cesáreas programados y de emergencias en el Hospital Nacional Hipólito Unanue 2019
Authors:   , Navarro Ramos Consuelo Margot
Published: July 2023

OBJETIVO: Conocer la frecuencia de cesáreas y factores para la indicación de cesáreas programadas y por emergencia del Hospital Nacional Hipólito Unanue en el año 2019 METODOLOGÍA Se realizó un estudio descriptivo, retrospectivo, observacional, transversal no experimental, donde se evaluaron 2805 casos. RESULTADOS: En el Hospital Nacional Hipólito Unanue se atendieron un total de 6630 partos de los cuales el 42,30% fueron por cesárea. Estas fueron 2806, de las cuales 1461 fueron realizadas por emergencia y 1344 programadas también llamadas electivas. Los principales factores para la indicación de cesáreas fueron el antecedente de tener una cesárea anterior y partos distócicos. Seguido por embarazo gemelar, el sufrimiento fetal agudo, placenta previa, él circular de cordón y el desprendimiento prematuro de placenta. CONCLUSIONES: Se determina la representación de trabajo la incidencia alta que existe en las cesáreas programadas del HNHU, comparadas con estudios realizados a nivel internacional, por ello la imperiosa necesidad de bajar esta frecuencia y prevalencia.
Nivel de conocimiento sobre medidas de bioseguridad de los internos de medicina humana de la Universidad Privada San Juan Bautista durante el periodo 2020
Authors:   , Charre Quispe José Carlos
Published: July 2023

Objetivo: Determinar el nivel de conocimiento sobre medidas de bioseguridad de los internos de medicina humana de la Universidad Privada San Juan Bautista durante el periodo 2020. Material y métodos: La presente investigación es caracterizada por ser de nivel descriptiva, transversal, retrospectiva y observacional, conformada por 192 internos de medicina humana de la universidad privada San Juan Bautista, encuestados por el instrumento de recolección de datos validado por expertos y por el coeficiente alfa de Cronbach obteniendo un grado de confiabilidad de 0.766. Los datos obtenidos fueron procesados en el programa estadístico SPSS versión 26. Resultados: Con respecto a la evaluación general de conocimientos de bioseguridad se determinó que el 92,2% de internos cuenta con nivel alto y el 7,8% con nivel medio. Sobre conocimiento de conceptos de bioseguridad se encontró un 91,1% con nivel alto, 7,3% con nivel medio y 1,6% con nivel bajo. En cuanto al conocimiento sobre materiales de barrera se obtuvo el 80,7% de nivel alto, 16,1% de nivel medio y 3,1% de nivel bajo. En la evaluación sobre conocimiento sobre eliminación de residuos contaminantes se determinó que un 89,6% de nivel alto, 7,8% de nivel medio y 2,6% de nivel bajo. no se encuentra asociación de edad y conocimiento con un p-valor de 0,356. Conclusiones: El nivel de conocimiento sobre medidas de bioseguridad de los internos de medicina humana de la Universidad Privada San Juan Bautista durante el periodo 2020 es de nivel alto, a su vez no se encuentra correlación de edad y el nivel de conocimiento.
Ambición y cumplimiento de objetivos de reducción de emisiones de gases de efecto invernadero.
Authors: gallego blasco anna , Zorio Grima Ana
Published: July 2023

Nuestros resultados muestran una relación positiva con las emisiones de gases de alcance 2, tamaño grande y sede en Europa, pero negativa con el alcance 3. Se necesitan medidas institucionales para reducir las emisiones y mejorar en sostenibilidad.
A method for capturing thin multi-layer regions of powder from powder bed fusion machines
Authors: Das Aniruddha , Weaver Jordan, , Tarr Jared , Moylan Shawn P
Published: July 2023

A powder capture capsule has been designed to capture thin regions of powder at multiple heights within a powder bed of laser powder bed fusion (LPBF) equipment. This design is stackable, support free, and allows powder capture from a targeted region (stacked layers) of the powder bed. Extraction is ergonomic, quick, and does not require any special tools; it also ensures sufficient powder for post analyses. An approximate apparent density of the powder bed pertaining to the region under investigation has also been evaluated in this test case.
TvBox: ferramenta para o aperfeiçoamento no processo de divulgação da Universidade Federal da Grande Dourados aos alunos de ensino médio, a partir de computadores em desuso
Authors: Gonçalves Clédison José , Mendonça Jane Corrêa Alves
Published: July 2023

Este trabalho tem como objetivo sugerir o desenvolvimento de um software que possa auxiliar e aprimorar o processo de divulgação do vestibular da UFGD, bem como seus cursos, projetos, e programas de assistência estudantil no âmbito regional, para alunos do ensino médio. Para isso, foi realizado um ensaio teórico abordando aspectos relevantes sobre comunicação pública e marketing educacional, a fim de compreender como essas ferramentas podem aprimorar a divulgação das instituições de ensino superior público e atender às necessidades dos alunos do ensino médio, fortalecendo a cidadania regional. Ao final da pesquisa, propõe-se o desenvolvimento de um sistema e seus processos para facilitar a comunicação entre a UFGD e os alunos do ensino médio na região de Dourados.
Φυματίωση οστών πρόσφατα επιδημιολογικά δεδομένα
Authors: Καράμπελα Ιρένα
Published: July 2023

Η φυματίωση είναι μια λοιμώδης νόσος η οποία συνοδεύει τον άνθρωπο από την αρχαιότητα. Ο Παγκόσμιος Οργανισμός Υγείας κατέγραψε το 2019 1,3 εκατομμύρια θανάτους παγκοσμίως με λοιμώδες αίτιο το Mycobacterium tuberculosis. Η νόσος παραμένει η κύρια αιτία θανάτου από ένα και μοναδικό λοιμογόνο παράγοντα χωρίς απαραίτητα να συνυπάρχει άλλος παράγοντας κινδύνου. Η λοίμωξη από το μυκοβακτηρίδιο της φυματίωσης χαρακτηρίζεται ως ο μεγάλος «μίμος» της ιατρικής λόγω του πλήθους των παραλλαγών στην κλινική εικόνα με την οποία εκδηλώνεται η νόσος. Το Mycobacterium tuberculosis εισέρχεται αερογενώς στον πνεύμονα που είναι η αρχική εστία της λοίμωξης και μπορεί να μεταφερθεί σε οποιοδήποτε όργανο του ανθρώπινου σώματος προκαλώντας νόσο. Η φυματίωση οστών και αρθρώσεων είναι μια σπάνια μορφή εκδήλωσης της νόσου και διαγιγνώσκεται με συχνότητα 1-2% των συνολικών περιστατικών με φυματίωση.Στην παρούσα μελέτη γίνεται προσπάθεια εκτίμησης της επίπτωσης τη φυματίωσης των οστών και των αρθρώσεων στην Ελλάδα κατά τη χρονική διάρκεια 2011-2019, καθώς τα επιδημιολογικά δεδομένα για τη συγκεκριμένη μορφή της νόσου είναι ελάχιστα. Σε χώρες με χαμηλή επίπτωση της νόσου, το κλειδί για την έγκαιρη διάγνωση είναι η υψηλή κλινική υποψία.Στη μελέτη εντοπίστηκαν 54 περιπτώσεις φυματίωσης των οστών και των αρθρώσεων στο Γενικό Νοσοκομείο «Σωτηρία» – Εθνικό Κέντρο Αναφοράς Φυματίωσης. Η μελέτη έδειξε ότι η πλειοψηφία των ασθενών με σκελετική φυματίωση ήταν άνδρες με ποσοστό 81,5%, ενώ λιγότερες ήταν οι γυναίκες με ποσοστό 18,5%. Από τα 54 κρούσματα σκελετικής φυματίωσης, το 79,6% ήταν γεννημένοι στο εξωτερικό και το 20,7% στην Ελλάδα.Η διάγνωση της σκελετικής φυματίωσης συχνά καθυστερεί λόγω μη ειδικών συμπτωμάτων και άτυπης κλινικής εικόνας της νόσου. Αυτή η σοβαρή κατάσταση μπορεί να οδηγήσει σε νευρολογικές επιπλοκές και σκελετικές παραμορφώσεις. Η διάγνωση γίνεται με αναρρόφηση με λεπτή βελόνα ή βιοψία και εν συνεχεία με καλλιέργεια του υλικού.Η θεραπεία της φυματίωσης των οστών και των αρθρώσεων περιλαμβάνει θεραπεία με αντιφυματική αγωγή, όμως η βέλτιστη διάρκεια θεραπείας είναι ένα ζήτημα που ακόμα δεν έχει επιλυθεί. Στην τρέχουσα μελέτη οι ασθενείς που έλαβαν θεραπεία φυματίωσης για χρονικό διάστημα μικρότερο από 9 μήνες είχαν 16,3 φορές μεγαλύτερο κίνδυνο αποτυχίας της θεραπείας ή υποτροπής της νόσου σε σύγκριση με ασθενείς που είχαν λάβει χημειοθεραπεία φυματίωσης για περισσότερο από 12 μήνες.
La identidad territorial, construcción conceptual y estrategia de lectura urbana
Authors: Herrera Valencia Ana Cristina
Published: July 2023

Este texto busca dilucidar la noción de identidad asociada al urbanismo y la relaciona de forma directa con el concepto de sistema patrimonial, integrando diversos componentes de este último como factores clave para soportar una propuesta metodológica de lectura integral del territo­rio, la cual relaciona el tiempo y el espacio como ejes determinantes. Una nueva visión sobre el concepto de patrimonio, alejada de una concepción monumental, requiere necesariamente nuevas formas de leerlo, observarlo, rastrearlo y documentarlo. Los elementos característicos de la identidad que expone este texto, permiten una búsqueda objetiva de las huellas, hechos, símbolos y manifestaciones que, más allá de las declaratorias institucionales del patrimonio, legitiman una relación cultural de una comunidad con su territorio y se concretan como ma­nifestación, evidencia y consolidación del paso del tiempo en el sistema patrimonial.
Tres Décadas en Diez Gráficos: El Desarrollo Inclusivo en América Latina a la Luz de las Encuestas de Hogares.
Authors: Bracco Jessica , Gasparini Leonardo
Published: July 2023

Este trabajo examina el desarrollo de América Latina durante las últimas tres décadas mediante curvas de incidencia del crecimiento y tasas de crecimiento ponderadas calculadas sobre la base de microdatos armonizados de encuestas de hogares. Durante las últimas tres décadas América Latina ha avanzado en términos de la mayoría de los indicadores básicos de desarrollo. En promedio, el crecimiento en el ingreso y en algunas variables educativas y habitacionales ha sido más intenso entre los estratos de menores ingresos. En contraste, en otras dimensiones importantes (ej. educación superior, participación laboral femenina) los avances fueron más lentos entre los más vulnerables. La evidencia señala que a pesar de los progresos en casi todas las dimensiones medibles del desarrollo en las encuestas de hogares, las carencias y las brechas siguen siendo enormes.
A sensitive tissue factor activity assay determined by an optimized thrombin generation method
Authors: Kristensen Søren Risom , Nybo Jette
Published: July 2023

Background

Tissue factor (TF) is the principal activator of the coagulation system, but an increased concentration in the blood in cancer and inflammatory diseases has been suggested to play a role increasing the risk of venous thromboembolism. However, measurement of the TF concentration is difficult, and quantitation of activity is the most valid estimation. The objective of this study was to establish a sensitive method to measure TF activity based on thrombin generation.

Methods

The assay is based on thrombin generation (TG) measured on the Calibrated Automated Thrombogram (CAT). Various low concentrations of TF were prepared from reagents containing 1 pM TF and 4 μM phospholipid (PPL), and no TF and 4 μM PPL, and a calibration curve was produced from Lagtime vs TF concentration. TF in blood samples was measured after isolation and resuspension of extracellular vesicles (EVs) in a standard plasma from which EVs had been removed. The same standard plasma was used for the calibrators.

Results

Contact activation of the coagulation system was avoided using CTI plasma samples in Monovette tubes. EVs contain procoagulant phospholipids but addition of PPL only reduced lagtime slightly at very low concentrations of TF resulting in overestimation to a lesser extent at 10 fM but no interference at 30 fM or higher. Addition of EVs to the TG analysis induced a small unspecific TF-independent activity (i.e., an activity not inhibited by antibodies against TF) which also may result in a smaller error in estimation of TF activity at very low levels but the effect was negligible at higher concentrations. It was possible to measure TF activity in healthy controls which was found to be 1–6 fM (EVs were concentrated, i.e. solubilized in a lower volume than the original volume plasma). Coefficient of variation (CV) was below 20% at the low level, and below 10% at a level around 100 fM TF. However, the step with isolation of EVs have a higher inherent CV.

Conclusion

A sensitive and rather precise one-stage TG-based method to measure TF activity has been established.
Ways to Organize Parallel Access to Structured Data
Authors: Ignatyev Alexey Olegovich , Mokshin Sergey Yurievich , Ivankov Dmitry Vladimirovich , Beketov Evgeny Alexandrovich
Published: July 2023

This paper explores ways to achieve the highest possible exchange performance with files containing structured data. The research was carried out on file systems with supercomputer systems parallel access designed to solve problems of physical and mathematical modeling of various processes and objects. For example, parallel access to raw data is considered using the Lustre file system. The article suggests a way to organize parallel access to structured data based on a specially developed PSIO storage format and the psio access library. A comparative analysis of the I/O performance of the developed data storage format and the HDF5 parallel version format is performed.
The Impact of COVID-19 on Relative Changes in Aggregated Mobility Using Mobile-phone Data
Authors: Heiler Georg , Hanbury Allan , Filzmoser Peter
Published: July 2023

Mobile-phone data can be used to investigate the mobility of a big part of a population in a given period. Here we have analyzed this information for Austria in the first half year of the COVID-19 pandemic. Especially the period around the first lockdown was of interest, and our focus is on exploring possible differences between age groups and among females and males. The data is once treated from an absolute point of view, by analyzing the numbers as they are reported and from a relative point of view, with the help of compositional data analysis tools. Our goal is to compare analyses of the absolute values and of relative information, in order to reveal possible differences in the groups formed by age and gender. It turns out that both types of analyses provide different and partially complementary insights. This is also underlined when analyzing data from call durations, or subdata just for specific Austrian districts.
O trato da questão social nos cursos de serviço social no interior do estado do Amazonas
Authors: Santos Sendy Lee Shoji , Andrade Roberta Ferreira Coelho de , Silva Escarlete Raíssa Evangelista da
Published: July 2023

A questão social na Amazônia possui particularidades, expressas em razão da própria sociobiodiversidade da região, devendo ser pensada de maneira crítica no âmbito acadêmico-profissional. Este artigo é resultado de pesquisa bibliográfica, documental e de campo, de natureza exploratória, o qual problematiza à luz do materialismo histórico e dialético como os cursos de Serviço Social de instituições de ensino superior no interior do Estado do Amazonas tratam a Questão Social na Amazônia dentro processo de formação profissional. Os resultados explicitaram a centralidade da questão social para a profissão, bem como propõem um debate sobre a mercantilização da educação superior e a construção de um projeto pedagógico de curso que abarque as particularidades regionais.
Didactic Strategy for the Use of Virtual Itineraries in the Training of Graduates in Education. Geography
Authors: Espinosa Oliday Aguilar
Published: July 2023

The training of teachers has always been a necessity of the planet aligned to the space and time where this process takes place. Future training of graduates in education, Geography who study geographic space need novel ways to appropriate these contexts and knowledge. The objective of this research was to propose a didactic strategy with the use of virtual didactic itineraries, in the teaching-learning process for the training of education, Geography in the first year of the career: Bachelor of Education. Geography, through the subject Introduction to Labor Practice, which contributed to deepen the knowledge about different landscapes and at the same time developed professional skills related to the study of the landscape. For the development of the research, information collection methods were used (participatory observation, document review, interview, expert criteria) and information processing methods (analysis – synthesis, inductive-demonstrative, logical history, descriptive statistics, modeling and analysis). The methods allowed to determine the needs of the students from the cognitive, educational and procedural point of view, regarding the teaching-learning process. The didactic strategy was implemented in practice, achieving very satisfactory results from the 2019-2022 academic years. It allows contributing to the development of professional pedagogical skills while deepening the knowledge of different landscapes in the students of the Degree in Education. Geography of the Faculty of Secondary Education of the Central University “Marta Abreu” of Las Villas, Villa Clara, Cuba.
EFFECT AND IMPLICATION OF BRONCHOSCOPIC BALLOON DILATATION IN A CASE OF TOTAL LUNG COLLAPSE
Authors: Srivastava Amit , Sharma Rachit , Manchanda Jay , Sadhwani Charu , Sharif Afrah
Published: July 2023

It is relatively uncommon for a young patient to have a severe airway blockage. Clinical suspicion of severe endobronchial anatomic alterations is uncommon. In certain situations, bronchoscopy results or radiographic findings are helpful in further assessment. Sarcoidosis, TB, and vasculitides cannot be diagnosed in our case because there is no clinical, radiological, or pathological evidence of these conditions. It is important to identify between benign and malignant tracheobronchial stenosis aetiologies, as well as to take into account the degree of aggression depending on the underlying condition and likelihood of cure. Additionally, it's crucial to take into account whether the obstruction is dynamic (tracheobronchomalacia) or fixed, particularly in the case of benign disease.
The Tipping Point - An Energy Efficient Medium Density Housing Development
Authors:   , Bellaney Briar
Published: July 2023

The building industry’s immense contribution to greenhouse gas emissions and the need for housing in New Zealand are both singular issues that need a combined solution set (Mulliner & Maliene, 2011). The current isolation between sustainability and the current housing market regarding New Zealand architecture suggests this is putting a halt to our desire for a ‘green’ country. Rapid construction and affordability are prioritised over the environmental impact of the building (Pullen et al., 2010).

Providing quality housing with minimal environmental impact are key issuesin society today, and how these are incorporated together will create the solution (Mulliner & Maliene, 2011). Sustainability is a broad term, so it is necessary to narrow this down by focusing on reducing the embodied and operational energy of the building (greenhouse gas emissions). My research will focus on finding a combined set of parameters to design quality, medium-density housing that reduces greenhouse gas emissions through decreased operational and embodied energy. Limitations of this research include the small umbrella of sustainability research in this thesis. Embodied and operational aspects are only one element that assists in designing sustainable housing. The disconnect between the current housing market’s quality and sustainability aspects drives this thesis.
ENGAGEMENT E AMBIENTE DE PRÁTICA DE ENFERMAGEM DOS ENFERMEIROS DE REABILITAÇÃO DA REGIÃO AUTÓNOMA DA MADEIRA
Authors: Leonardo Correia Martins João , Raquel Figueira Ornelas de Gouveia Bruna , Henriques de Jesus Élvio , Merícia Gouveia Rodrigues Bettencourt Jesus Maria
Published: July 2023

A investigação científica tem manifestado um grande interesse pelo engagement no trabalho dos enfermeiros, procurando determinar os seus níveis de expressão e os fatores que contribuem para a sua manifestação. Por ser um tema de incontornável relevância para as organizações de saúde, objetivamos: I) conhecer os níveis de engagement dos Enfermeiros Especialistas em Enfermagem de Reabilitação (EEER); II) descrever a sua perceção relativamente à favorabilidade do ambiente de prática de enfermagem (APE) e III) analisar a relação entre as características do APE e o engagement. À uma amostra de 113 EEER foram aplicadas as escalas Utrecht Work Engagement Scale (UWES) e Practice Environment Scale of the Nursing Work Index (PES-NWI). Os resultados revelaram níveis moderados a elevados de vigor, absorção e dedicação que variaram significativamente em função da idade e do tempo de profissão. O ambiente de prática de enfermagem foi percecionado como misto, com três dimensões avaliadas favoravelmente e duas avaliadas desfavoravelmente. Foram encontradas correlações significativas entre o APE e o engagement. O estudo reforça a importância de assegurar ambientes favoráveis à prestação de cuidados de enfermagem e, com isso, contribuir para o reforçar do vínculo à profissão e elevar os níveis de dedicação, foco e energia no trabalho.
АНАЛІЗ ХАРАКТЕРИСТИК МАЛОПОТУЖНОГО ФІЛЬТРА НА ТРАНЗИТОРНИХ АНАЛОГАХ ІНДУКТИВНОСТІ ЯК АЛЬТЕРНАТИВИ ФІЛЬТРІВ НА ПОВ’ЯЗАНИХ РЕЗОНАТОРАХ
Authors: ОСАДЧУК Олександр , ДУМЕНКО Денис
Published: July 2023

У статті проаналізовано основні характеристики малопотужних смугопропускаючих фільтрів. Розглянуті фільтри на пов’язаних резонаторах та запропоновано використання транзисторних аналогів індуктивності як їх альтернатива. Досліджена зміна основних параметрів компонентів фільтрів при заміні основного елемента на транзистор. Охарактеризовані основні аспекти та досліджений коефіцієнт передачі фільтра з використанням транзисторного аналогу індуктивності. Розглянуто режим роботи малого сигналу транзистора та його основні умови.  Проаналізовані умови яким потрібно слідувати при виборі активного елементу. Наведено залежність роботи  та параметрів транзисторів від живлення по постійному струмові, його стабільності та безперебійності. Проаналізовано можливість використання несиметричної смугової лінії передачі з діелектричним заповненням.
Análise e modelação de risco no ordenamento do território
Authors: Nunes Adélia , Lourenço Luciano
Published: July 2023

O décimo primeiro volume da série Estudos Cindínicos, é constituído por seis capítulos que têm como denominador comum a análise e a modelação de riscos (hidrológicos, geomorfológicos, climáticos/meteorológicos) como ferramentas indispensáveis no ordenamento do território, na redução do risco de desastre e no fortalecimento da resiliência ambiental e social. Tendo o ordenamento do território como finalidade acautelar a proteção da população e bens, através de uma ocupação, utilização e transformação do solo que tenham em conta a segurança de pessoas, prevenindo riscos coletivos e reduzindo os seus impactes nas pessoas e ecossistemas, torna-se imperioso conhecê-lo para que as que decisões que venham a ser tomadas sejam informadas e eficientes. Neste contexto, a análise e modelação da informação geográfica, quantitativa ou qualitativa, permite o conhecimento mais detalhado do território. Embora a modelação geográfica implique sempre uma simplificação da realidade, tornando-a manipulável, os resultados obtidos permitem uma aproximação à previsão do comportamento do território e dos fenómenos nele desenvolvidos, bem como dos agentes que intervêm no mesmo. Assume, assim, grande relevância na gestão e ordenamento do território, bem como ferramenta para a tomada de decisões sobre oportunidades, condicionantes, prevenção e mitigação de riscos. Trata-se, sem dúvida, de um livro de elevada utilidade para investigadores, decisores públicos, professores e estudantes, com interesse nestas matérias ou com responsabilidade na análise e gestão dos riscos e no ordenamento do território.
Compliance como instrumento de integridade e combate à corrupção nas contratações públicas: uma análise do tema à luz da Lei n° 14.133/2021
Authors: Costa Rainho Renata
Published: July 2023

O artigo tem por objetivo geral analisar a legislação municipal, estadual e distrital com previsão de obrigatoriedade de adoção de programas de integridade pelos contratados, e por objetivo específico a análise das disparidades existentes entre as normas e que acabam por gerar obrigações distintas no mercado, sem olvidar da ulterior regulação por normas gerais feita pela Lei n° 14.133/2021. O marco teórico da pesquisa é o conceito de regulação de Fábio Carvalho, e o artigo se desenvolve a partir da análise das normas com previsão de adoção de programas de integridade na contratação pública, para na sequência problematizar os incentivos que se pretende gerar no mercado e, por fim, estudar a superveniência da Lei n° 14.133/2021, discutindo o acerto das regras gerais da citada norma.
Palavras-chave: compliance, integridade, licitação, obrigatoriedade, incentivos.
The Legal transplant during the democratic transition: the regional migration of a constitutional idea : The spread of qualified law in the central and East-European regions
Authors: Szentgáli-Tóth Boldizsár
Published: July 2023

This academic contribution analyses the recent migration of a constitutional idea as a legal transplant in Central and Eastern Europe: the implementation of qualified law in several countries during their democratic transition. A cursory glance at the regional dimension of this constitutional instrument provides new insight into the role of qualified legislation during political transitions and leads to valuable experience regarding the migration of constitutional ideas in Central and Eastern Europe. It is demonstrated how the external, mainly Western European examples influenced the constitutional development of this region, and how the new democratic frameworks inspired each other within Central and Eastern Europe.
Serie de casos de sangrado intraluminal postoperatorio en colectomía izquierda.
Authors: Alaniz Alday Maria Jimena , Ramisch Diego A. , Bianchi Romina , Leiro Fabio , Gondolesi Gabriel
Published: July 2023

Introducción: El sangrado digestivo post operatorio intraluminal es una entidad poco frecuente y su manifestación clínica no difiere de la hemorragia digestiva baja de otra etiología. A pesar de que su presentación más habitual es la hematoquecia autolimitada en la primera deposición, en un discreto porcentaje puede requerir transfusiones, tratamiento endoscópico, hemodinámico e incluso cirugía.

Objetivo: El objetivo de la siguiente presentación es analizar cuatro casos tratados en un centro de alta complejidad y realizar una revisión bibliográfica del tema.

Material y Métodos: Estudio retrospectivo descriptivo de pacientes con sangrado anastomótico durante el post operatorio inmediato de colectomía izquierda en el Servicio de Cirugía General y Coloproctología, desde enero del 2017 a diciembre del 2021. Contemplamos las variables: edad, sexo, anticoagulación y su causa, descenso de hemoglobina, cirugía realizada e indicación de la misma, abordaje, configuración de anastomosis, electividad de la cirugía, complicaciones, días de internación y manejo terapéutico.

Resultados: La incidencia según sexo fue de (1:1) y la edad media fue de de 72 años (rango 54- 87). A todos se les realizó una colectomía izquierda de forma programada y el abordaje fue laparoscópico en 3 casos (75%). En todos los casos se confeccionó una anastomosis termino-terminal con sutura mecánica circular. Todos los pacientes presentaron sangrado en las primeras 24 horas postoperatorias.  El tratamiento fue decidido de acuerdo a la condición hemodinámica: En el 50% de los casos (n=2) que no presentaron inestabilidad hemodinámica, el tratamiento conservador con reanimación y transfusiones fue suficiente. Los 2 casos que presentaron inestabilidad hemodinámica requirieron manejo intervencionista con endoscopía rígida, video colonoscopia flexible y cirugía.

Conclusiones: El sangrado intraluminal es una complicación poco frecuente de la anastomosis colorrectal, requiriendo solo en un pequeño porcentaje tratamiento médico hasta incluso manejo intervencionista, sobre todo en los casos que se presentan con inestabilidad hemodinámica.
Ferramenta computacional voltada ao ensino de proteção de sistemas elétricos de potência
Authors: De Paiva Anderson Tadeu Soares , De Lima Alanio Ferreira , E Silva Carlos Elmano de Alencar , Sampaio Raimundo Furtado
Published: July 2023

Os sistemas de proteção são parte fundamental e cada vez mais relevante dentro do Sistema Elétrico de Potência (SEP), seja pela sua importância na manutenção do fornecimento de energia elétrica aos consumidores, seja pelo seu papel na segurança dos equipamentos que compõem o SEP. Diante deste cenário, a Universidade Federal do Ceará(UFC) vem desenvolvendo um Simulador para Treinamento Presencial e a Distância em Operação e Proteção de Sistemas Elétricos (STOP) (SILVA, BARROSO, LEÃO, SAMPAIO, & SOARES, 2011). Desenvolvido em JAVA e integrado à plataforma de ensino a distância Moodle, o STOP já possui um Módulo para Treinamento em Proteção de Subestação Distribuidora de Energia. Este trabalho apresenta o desenvolvimento de um Segundo Módulo (Módulo II) que consiste em um Módulo de Treinamento voltado paras as Proteções de uma Subestação de Transmissão da Rede Básica, 500-230 kV, integrado ao STOP. Este Módulo II do STOP permitirá configurar e simular proteções de uma subestação de transmissão da rede básica, baseando-se nos critérios definidos pelo Operador Nacional do Sistema (ONS) através de seus Procedimentos de Rede (PROREDE).
Transformando las actitudes hacia la estadística y su enseñanza: un estudio exploratorio con maestras de Educación Infantil
Authors: Vásquez Ortiz Claudia
Published: July 2023

Este estudio busca determinar el impacto que tiene un taller formativo sobre enseñanza de la estadística en Educación Infantil -asociado a la caracterización de los Conocimientos para Enseñar Matemáticas en Educación Infantil- en las actitudes hacia la estadística y su enseñanza de 37 maestras chilenas de infantil. Para ello, se consideró un enfoque metodológico mixto que consideró la aplicación de la escala de actitudes hacia la estadística y su enseñanza antes y después del taller formativo. Lo anterior, fue complementado con la valoración del grado de satisfacción global con la experiencia formativa; incluyendo aquellos aspectos que las maestras consideran necesarios abordar o mejorar en implementaciones futuras. Los resultados indican un cambio significativo en las actitudes de las maestras participantes, en todos los componentes de la escala. Por consiguiente, se concluye que es imperativo ofrecer al profesorado de esta etapa educativa oportunidades de desarrollo profesional que les permitan mejorar sus actitudes hacia la estadística y su enseñanza y, por qué no, sus conocimientos matemáticos y didácticos en torno a la enseñanza de la estadística en Educación Infantil.