bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF STRATEGIC PLANNING AND PERFORMANCE MANAGEMENT ON BUSINESS AND PRODUCTION PROCESS
Authors: Sitanggang Juninetenth Keeply F.
Published: March 2023

A business process is a set of activities that designed to produce an output for aparticular customer or market. It’s emphasis on how the work within an organization, in contrastto a product's focus on what a process is. Thus the specific sequence of work activities in all timesand places, with the beginning, end, and input, output, and structure of the action clearly defined.The purpose of this study to determine whether the strategic planning and performancemanagement effect on business and production process on the three universities in SDA amongIndonesia region. This research uses the questionnaire to collect data and using Pearson productmomentto find the relationship and effect of the variable. The result shows that the correlationamong at variables was having a significant relationship between strategic planning, and businessproduction process with the coefficient correlation of 0.720 that mean the correlation was strong.Performance management on a business production process coefficient correlation of 0.780 thatmean the correlation was strongly positive and the relationship between variables strategicplanning, and performance management on business production process was 0.823 strongpositive. The contribution of these two variables strategic planning and performance managementon business and production process was 67,7% and the rest 32,3% determined by other variablesor factor's out of this research. Also, there is a relationship between strategic planning andperformance management to business and production process with f Value of 169.813. Theregression equation is BP = 0.583 + 0.361SP + 0.481PM.
FACTORS ANALYSIS OF FOOTWEAR TRADE INDUSTRY OF INDONESIA MAIN EXPORT DESTINATION
Authors: Simanjuntak Darwin
Published: March 2023

This study aims to identify the factor that affecting the footwear trade industry in Indonesia based on Indonesia main export destination. Understanding these factors could help leaders in trade industry institutions to better plan their strategies and further research on footwear trading. A set of data was obtained from Badan Pusat Statistic (BPS) based on data from Indonesia footwear main export destination namely: United States, China, Belgium, Germany, Japan, United Kingdom, Netherlands, Korea, Italy, Australia, Mexico, France, Canada, Denmark, Singapore, Brazil, Hong Kong, Russian Federation, Chile, Argentina and Other Countries. Exploratory factor analysis was used to identify the underlying dimensions of countries as Indonesia main export destination. By applying the factor analysis, the study will decide the number of factors to be retained and the total variance explained by these factors; the study can identify the variables in each factor retained in the final solution, on the basis of its factor loadings; the study can give names to each factor retained on the basis of the nature of the variables included in it; the study can suggest the test battery for assessing the footwear trade main export destination in Indonesia; and the study can test the adequacy of sample size used in factor analysis. The result of the study shows that KMO value is 0.784 which is > 0.5; hence, the sample size is adequate for the analysis and the commonalities of all the variables are more than .4; hence, all the variables are useful in the model. Since the variables are identified in factor 0.7 or more, the result shows that all factors which are from the year 2012-2016 contributed to the exports of footwear in Indonesia.
PERENCANAAN STRATEGIS, ANGGARAN DAN KINERJA KEUANGAN
Authors: Manalu Herold Moody
Published: March 2023

This  study  aimed  to  determine the  effect  of  strategic planning  and budgeting to financial performance. The population in this study were faculty and supporting staff at Bandung Adventist School. The research sample using a saturated sample of 56 respondents, the instrument used was a questionnaire’s. Method of analysis used was a regression. The results showed the correlation coefficient r = 0.507, where the relationship between variables was positive and the coefficient determination by 25,7%, and as much as 74.3% by the other factors. The result suggests strategic planning and budgeting has a significant effect on financial performance by P-value 0.000 < 0.05
FACTOR ANALYSIS OF STUDENT PERCEPTION ON UNIVERSITAS ADVENT INDONESIA AS FAVORITE HIGHER EDUCATION INSTITUTION
Authors: Hutabarat Reymand M , Hutabarat Franklin
Published: March 2023

This purpose of the study is to look on factors of in student perception on their reason whyUniversitas Advent Indonesia is their favorite higher education institution. By knowingthese factors could help the stakeholder of the university in their plan. A set of theinstrument of the questionnaire was acquired and distributed to 100 students respondent atUniversitas Advent Indonesia (UNAI). Exploratory factor analysis was used to distinguishthe underlying dimensions that drive student satisfaction. Factor analysis pertaining toanalysis on dimensions of Favorite University. The results show that the KMO test isvalued at 0.741 which is > 0.5; hence, the sample size is adequate for the analysis. On theother hand, the commonalities of all the variables are exceeding .4; consequently, all thevariables are useful in the model. The results show that factors in the analysis of studentsatisfaction on academic courses at UNAI are that the factor of student perception on UNAIas their favorite higher education institution is Facility and Quality of Education.
PENGARUH BRAND POSITIONING DAN BRAND EQUITY TERHARAP KEPUTUSAN PEMBELIAN KENDARAAN
Authors: Memey Memey , Siagian Harlyn Lindon
Published: March 2023

This study aims to examine and determine the effect of brand positioning and brand equity on the decisions of vehicle buyers. This research was conducted at PT. Arista Group with a sample of buyers or consumers who come to the company. The data processing method used in this study is descriptive statistical analysis, correlation coefficient test, coefficient of determination test, simple linear regression analysis, classic assumption test and hypothesis test (F test and t test) and multiple linear regression analysis. The results in this study indicate that multiple linear regression analysis is Buyer Decision = 5,559 + 0.720 BP + 0.113BE which means, the constant of 5,559 states that if there is no brand position and brand equity, the buyer's decision is 5,559. Partial hypothesis testing (Test t) brand positioning produces a coefficient obtained sig for the variable brand position is 0.000 then 0.000 <0.05 so Ha is accepted. Then t arithmetic is 6.403, then t count 0.05 so that H0 is accepted. Then you can see t count is 1,386, then t count> t table so there is in the area H0 accepted. So partially brand equity has a significant effect on buyer decisions. The conclusion is that there is a significant effect of brand positioning and brand equity on vehicle purchase decisions at PT. Arista Group.
DIVERSIFIKASI PRODUK TERHADAP PENJUALAN LAMPU ROMANTIS BATU AKIK (LAPIS BATIK) PURBALINGGA
Authors: Faizin Muhammad , Azizah Nur , Hayati Fitri
Published: March 2023

Meningkatnya jumlah permintaan batu akik di pasar nasional, mengakibatkan jumlah pemesanan batu akik setiap daerah ikut meningkat. Termasuk di Kabupaten Purbalingga sebagai salah satu daerah penghasil batu akik. Peningkatan minat masyarakat membuat pengrajin dan pemasar melonjak tinggi. Namun terjadi penurunan sebesar 80% dibandingkan saat menjadi trending topic. Hal ini menyebabkan nilai jual batu akik menjadi turun. Berdasarkan data tersebut, penelitian ini bertujuan untuk meningkatkan nilai jual batu akik dengan cara diversifikasi produk yang unik, kreatif, dan inovatif. Produk tersebut diberi nama LAPIS BATIK (Lampu Romantis Batu Akik). Penelitian ini menggunakan analisis rata-rata pertumbuhan dan analisis data hasil penjualan produk baru sedangkan metodenya adalah metode penelitian deskriptif dengan pendekatan studi kasus. Hasil dari penelitian ini yaitu membuktikan bahwa diversifikasi produk telah  memberikan kontribusi yang baik dalam volume penjualan total dan omzet penjualan total sesudah diversifikasi produk dan Presentase produk terjual adalah 88,89% dari total produksi selama empat bulan penjualan dengan total pendapatan Rp 6.100.000,00.
PENGARUH TAX AVOIDANCE DAN LIKUIDITAS TERHADAP UKURAN PERUSAHAAN PADA SUB SEKTOR PERDAGANGAN YANG TERDAFTER DI BEI
Authors: Marpaung Romian , L. Siagian Harlyn
Published: March 2023

Dengan adanya penelitian ini bermanfaat untuk menguji pengaruh penghindaran pajak dan likuiditas terhadap ukuran perusahaan. Ukuran perusahaan merupakan indikator kinerja keuangan pada perusahaan. Data dalam penelitian ini adalah data sekunder yang diperoleh dari Bursa Efek Indonesia pada sub sektor perdagangan pada tahun 2017-2019. Penelitian ini menggunakan metode kuantitatif. Variabel penelitian yaitu tax avoidance (X1), likuiditas   (X2) dan stuktur modal (Y). Metode analisa data yang penulis gunakan yaitu analisa asumsi klasik. Hasil uji dari penelitian ini membuktikan bahwa penghindaran pajak dan ukuran perusahaan memiliki pengaruh signifikan, likuiditas dan ukuran perusahaan memiliki pengaruh signifikan.
PENGARUH SOLVABILITAS TERHADAP AUDIT REPORT LAG DENGAN MEDIASI CORPORATE GOVERNANCE PADA PERUSAHAAN TAMBANG YANG TERDAFTAR DI BEI 2017-2018
Authors: Indri Tarigan Efata , Yuliana Hutapea Joan
Published: March 2023

The purpose of this study is to analyze the effect of solvency on the lag audit report with corporate governance as a mediating variable in companies listed on the Indonesia Stock Exchange for the period 2017-2018.  Descriptive analysis will be used in this study and then processed using SPSS software. The sample in this study are: 20 (twenty) mining companies that listed on the Indonesia Stock Exchange for the period of 2017-2018.  This study uses solvency as the dependent variable and audit report lag as an independent variable and corporate governance as a mediating variable. This study uses the square-R, t-significance, and regression analysis. The results of the analysis carried out in this study indicate that solvency has no significant effect on Audit Report Lag, Corporate Governance has a significant effect on Audit Report Lag, and Solvency has no significant effect on Audit Report Lag with the mediation of Corporate Governance.
PENGARUH TAX AVOIDANCE DAN TRANSPARANSI TERHADAP NILAI PERUSAHAAN PADA SUB SEKTOR OTOMOTIF YANG LISTING DI BEI
Authors: Meilani Marpaung Chatherine , Manalu Moody
Published: March 2023

Adapun tujuan penulisan dalam penelitian ini adalah untuk memberikan bukti bahwa adanya pengaruh  penghindaran  pajak  pada nilai perusahaan  dengan transparansi sebagai variabel moderasi pada perusahaan yang listing di Bursa Efek Indonesia periode 2017-2019 pada subsektor otomotif, dan diharapkan agar dapat memberikan bukti  empiris  tentang peran  kebijakan  hutang  dalam  memoderasi pengaruh  penghindaran  pajak pada nilai perusahaan.  Penulis melakukan penelitian ini dengan menggunakan analisis deskriptif yang dibantu dengan menggunakan aplikasi SPSS. Data penelitian memakai laporan keuangan berupa data sekunder dari 7 Perusahaan yang listing di BEI dalam periode 2017-2019 pada Subsektor otomotif. Uji statistic deskriptif, Uji kelayakan model, Uji hipotesis (Uji T) merupakan analisis data yang diambil dalam penelitian. Hasil uji model 1 menunjukkan bahwa penghindaran pajak memiliki pengaruh yang signifikan nilai perusahaan. Hasil uji model 2 didapati dimana antara Transparansi dengan Nilai perusahaan terdapat pengaruh yang signifikan. Dan hasil uji model 3 didapati  adanya pengaruh yang signifikan dalam hubungan Tax Avoidance dan Transparansi terhadap Nilai Perusahaan. Tax Avoidance pada Nilai Perusahaan dan Transparansi sebagai variabel moderasi.
PENGARUH PENGHINDARAN PAJAK DAN SOLVABILITAS TERHADAP HARGA SAHAM
Authors: Elisa Purnama Hutajulu Aprilliani , R. Simbolon Maropen
Published: March 2023

Penelitian dilakukan bertujuan untuk menyelidiki apakah adanya pengaruh Penghindaran Pajak dan Solvabilitas terhadap Harga Saham. Sampel penelitian ini dilakukan melalui  data dari laporan keuangan pada  Perusahaan property dan real estate tahun 2018-2019.  Populasi penelitian ini  menggunakan data dari 29 perusahaan property dan real estate dengan 58  sampel yang tercantum di Bursa Efek Indonesia (BEI). Penelitian ini menggunakan teknik analisa uji deskriptif, uji koefisien determinasi dilakukan untuk menetapkan nilai R2, regresi, analisis mediasi, dan sobel test. Hasil dari penelitian menunjukkan terdapat pengaruh yang signifikan antara penghindaran pajak dengan indikator ETR dan harga saham. Tidak adanya pengaruh yang signifikan antara penghindaran pajak dan Solvabilitas.  Adanya pengaruh yang signifikan antara penghindaran pajak dan Solvabilitas dan harga saham.
MEDIASI HARGA SAHAM ANTARA PROFITABILITAS, INVESTMENT OPPORTUNITY SET (IOS) DAN NILAI PERUSAHAAN
Authors: Yuliana Hutapea Joan , R. Rajagukguk Alden
Published: March 2023

The purpose of this study is to  investigate the influence of Profitability (Net Profit Margin) and Investment Opportunity Set (Price Earning Ratio) to the firm’s value in the oil and gas company listed at Bursa Efek Indonesia (BEI) by the period of 2014-2018. Using purposive sampling techniques, there are 7 companies that being selected that fulfill the criteria for the research sample. The result shows that: 1) Profitabilty has not significant influence to the Price Share, 2) IOS has not significant influence to the Price Share, 3) Profitability has not significant influence to the firm value, 4) IOS has not significant influence to the Firm Value, 5) Price Share has not significant influence to the Firm Value, 6) Price Share can’t mediate the influence of Profitability to the Firm Value, 7)Price Share can’t mediate the influence of IOS to the Firm Value.
MEDIASI RASIO UTANG ANTARA RASIO LANCAR DAN PENGHINDARAN PAJAK PADA PERUSAHAAN MINYAK BUMI & GAS YANG TERDAFTAR DI BEI TAHUN
Authors: Sihombing Vitri , Pangaribuan Hisar
Published: March 2023

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis apakah terdapat pengaruh antara rasio lancar, dan Penghindaran Pajak perusahaan dengan rasio utang sebagai variabel mediasi. Penelitian ini mengambil industry minyak bumi dan gas yang terdaftar di Bursa Efek Indonesia ( BEI ) tahun 2017-2019 sebagai populasi. Teknik purposive sampling menghasilkan 21 sampel terpilih yang kemudian penelitian ini dapat gunakan. Melalui hasil analisis regresi berganda dapat dilihat bahwa rasio lancar berpengaruh signifikan kepada Penghindaran Pajak. Sedangkan rasio utang sebagai variabel mediasi memiliki pengaruh signifikan kepada Penghindaran Pajak perusahaan.
ROLE OF LEVEL OF INCOME AND EDUCATION ON DIGITAL DIVIDE: A LOOK AT JAKARTA WORK FORCE
Authors: Purba Heddry , Hutabarat Francis
Published: March 2023

Communication technologies is important in supporting economic, human, and social growth. However, it common knowledge that communication technologies are differ between countries. And the digital difference inside nations can be as high as that between countries. ). The objectives of this study are to assess the Indonesia home digital divide for its Jakarta workforce and to examine the demographic features, specifically: education and level of income as factors influencing digital divide. The study is descriptive and survey questionnaire is employed. Indonesian workers in Jakarta and graduates of the Indonesia Adventist University in Bandung are the study's subjects. There are 239 sample of the study. Frequencies, correlation, significant test, and regression test were used in the analysis. The study found that, simultenously, there is a significant relationship between education and level of income on digital divide of Jakarta workforce. The study also indicates there is no significant relationship based on t-test between education and digital divide. On the other hand, level of income shows that it has significant result with t-test at 10% level of significant.
Women, Sexuality, Violence: #Me Too!
Authors: Coltri Marzia A. ,   Academic Publishing
Published: March 2023

Historically women’s achievements have been obscured, sexually, socially, culturally, and spiritually. However, with the rise of global and social media, women have been empowered, having a greater impact on society; women are more receptive to discussions related to ethical and social issues - such as racial, national, and sexual discrimination, elimination of violence, religious control, free movement, modern slavery, psychological submission, and poverty/ economic marginalization – and are at the forefront of international movements, such as #MeToo and #SheDecides, which promote freedom of speech, thought and belief, and how to speak out publicly. Issues related to ethnic, religious, and sexual persecution and violence are part of women’s history. A critical thinking approach to the struggle of women in modern society is essential; it is important to understand female leaders as part of a multi-ethnic, multi-faith, and multi-gendered society. Women in postcolonial movements construct their self-identity in real, concrete, and existential sociocultural contexts. This article discusses violence against women, women contributing to a diverse global society, and women’s ideas of beauty and sexuality. I employ the lens of autocoscienza (self-awareness) with a view to embracing diversity and vindicating contribution of women in religious and secular contexts, and its value for the future.
Furthering The Voice of Misery
Authors: van der Heiden Gert-Jan ,   Philosophy Documentation Center
Published: March 2023

In this essay, the author takes up the responses of Dennis J. Schmidt and Carolyn Culbertson to his monograph The Voice of Misery: A Continental Philosophy of Testimony. It first observes that both respondents have a shared interest in the ethical dimension of the question of testimony, which has much to do with the exceptional subject matter, namely that of bare life, that The Voice of Misery takes as its point of departure to analyze what testimony is. In the first section, the author engages with Schmidt’s account of the importance of Heidegger, Plato’s myth of Er and Celan’s poetry for thinking testimony and shows how exactly these references allow us to think the ethos and the ethics of textimony. In the second section, he discusses the three questions Culbertson raised concerning the practical, more everyday stakes of testimony in relation to the epistemology of testimony and the question of epistemic justice.
Kidney Segmentations Using CNN models
Authors: MANSOUR Mohammed , DEMİRSOY Mert Süleyman , KUTLU Mustafa Çağrı
Published: March 2023

For medical diagnostic tests, kidney segmentation from high-volume imagery is an important major. Since 3D medical images need a lot of GPU memory, slices and patches are used for training and inference in traditional neural network variant architectures, which necessarily slows down contextual learning. In this research, Mobile Net and Efficient Net CNN models were trained for segmenting human kidney images generated from The Human Biomolecular Atlas Program (HuBMAP). The purpose of this work is to evaluate the effectiveness of different strategies for Glomeruli identification in order to solve the issue. The high size images were decoded to be fitted and trained in the models first, then the CNN models were trained. The CNN models result show that the Efficient Net has the highest accuracy rate with 99.49 %, and Mobile Net with 99.33 %.
Field-trip guide to the geochronology of El Malpais National Monument and the Zuni-Bandera volcanic field
Authors: Laughlin A. William , Charles R. W. , Reid K. , White C.
Published: March 2023

This field guide grew out of the 1993 Quaternary Dating Field Conference held in Grants, New Mexico, in April 1993. The conference, sponsored by the New Mexico Geochronology Research Laboratory (NMGRL) and the U.S. National Park Service, was convened to consider using the Zuni-Bandera volcanic field, including El Malpais National Monument and El Malpais National Conservation Area, as a test area for evaluating, calibrating, and improving the application of Quaternary dating techniques. Improvement of the accuracy and precision of these dating techniques is one of the major goals of the NMGRL, which was established in 1992 as a collaborative effort of the N Bureau of Mines and Mineral Resources, the NMIMT, and the Los Alamos National Laboratory. Much of the land that a visitor will cross in the two days of this field trip is owned by the Ramah Navajo, Zuni, Laguna, and Acoma tribes, or is under the jurisdiction of the U.S. National Park Service or the Bureau of Land Management. Their permits are required for sample collection.

The Zuni-Bandera volcanic field is located in west-central NM south of the town of Grants. It lies near the center of the Jemez zone or lineament that extends at least from central Arizona to northeastern NM. The Jemez lineament is a major flaw in the Earth's crust along which volcanoes have erupted for the past 16 Ma. Approximately 100 volcanoes have been identified in the Zuni-Bandera volcanic field. The youngest volcanic activity along the lineament occurred in the area now encompassed by El Malpais National Monument, where volcanoes have erupted from about 700-3 ka. Because of the youthfulness of these lava flows, they are well preserved, providing the Monument visitor with spectacular views of volcanic landforms and the geologist with an ideal area for investigating volcanic processes.

One of the more important aspects of research in the Zuni-Bandera volcanic field is the geochronology of the many volcanic eruptions. Determination of the absolute ages of these basaltic volcanoes is fundamental to other geological, geochemical, and isotopic studies. Although there are several dating techniques that should be applicable to volcanic rocks of this age, their results have rarely been compared in a single area, and, where this has been attempted, they are often not in agreement. The Quaternary Dating Field Conference was convened to address this problem by assembling a group of researchers interested in applying their specific techniques to a common sequence of lava flows with the goal of improving their accuracy and precision, with the hope of improving our understanding of the significance of the results obtained by the different techniques. A secondary objective was the refinement of the geochronology of the area.
History of PTMC at National Institute of Cardiovascular Diseases Karachi.
Authors: Shah Zaman Khan
Published: March 2023

Rheumatic mitral stenosis (MS) incidence and severity rates have decreased in the developed world, but the condition is still very common in many nations. Since its invention, percutaneous mitral balloon valvuloplasty has transformed the therapy of mitral stenosis, shown promising short- and long-term outcomes, and taken the role of surgical mitral commissurotomy as the preferred method of managing rheumatic mitral stenosis in suitable patients. The morphologic characteristics of the valve leaflets and sub valvular structures can be used to predict the possibility of hemodynamic benefit and the danger of complications with balloon valvuloplasty. The results will be less than ideal if the valves are hard, thickened, and extensively calcified. We presented the retrospective data of approximately 500 patients from March 2001 to June 2006 in this paper.
STEMI Pakistan; A National Heart Attack Management Program.
Authors: S Nishtar Salman
Published: March 2023

Coronary artery disease (CAD) accounts for more than two-thirds of these deaths. It is indicated per the latest information that one in four Pakistani adults over 40 has CAD.

The stable coronary disease has a relatively low annual mortality, while acute myocardial infarction (MI) carries a high mortality and morbidity. Though recent advancements in coronary interventions have however revolutionized the management of acute myocardial infarction, resulting in a significant reduction of cardiovascular morbidity and mortality in the developed world but  in Pakistan, the majority of ST-elevation myocardial infarction (STEMI) patients still remain sub-optimally managed. Urban areas are relatively better equipped, but this does not necessarily translate into universal access to quality and timely cardiac care. There is not only substantial variation in accessibility and practices amongst cardiac healthcare facilities between rural and urban areas but also amongst major city hospitals.  Such variations clearly indicate an urgent need for a nationwide standardized STEMI management program to ensure that everyone with an acute STEMI will have speedy access to quality and standard acute care without being economically burdened.
Short term Outcomes of left main coronary artery Percutaneous Coronary Intervention A large tertiary care dedicated Cardiac Centre experience.
Authors: Ullah Abid , Ishaq Muhammad , Jan Rafiullah , Raza Ali
Published: March 2023

Background: Left main coronary artery intervention is getting common throughout the world. Data in our local population are still lacking. Our aim was to study the short-term outcomes after revascularization of left main coronary artery (LMCA) at a tertiary care Centre at public sector hospital in Pakistan.

Methodology: In this descriptive study conducted at Peshawar Institute of Cardiology, we enrolled consecutive patients who underwent LMCA intervention from January 2021 till November 2021. Direct patients’ interviews, reviewing charts and records were used for in-hospital outcomes and telephonic and physical follow up were used to document three months outcome. Results were expressed as means, standard deviations and percentages for different variables.

Results: Total number of patients in the study were 68. The mean age was 61 ± 11.7 years, 73.5% (50 cases) were males. Six patients (8.8%) were in cardiogenic shock and five of them were put on mechanical ventilation. Thirty-two (47.1%) patients had presentation as acute coronary syndrome (ACS) within the last seven days. Mean follow up time was 170 ± 71 days. Mortality in-hospital was 5.8%, at the mean follow up it was 8.8%.

Conclusion: Comparable short-term outcomes of left main coronary artery PCI, to national and international data can be achieved in a public sector hospital in our country where resources are scarce. Hence LMCA PCI is an acceptable alternative to CABG in suitable patients.
Comparative outcomes of MACE after Drug eluting balloon Vs. Drug Eluting Stent in treatment of in-stent restenosis (ISR) patients presented with acute coronary syndrome.
Authors: Khan Shahsawar , Khan Adnan , Bukhari Jasia , Idrees Khan Muhammad , Uddin Imad
Published: March 2023

Background: Currently, patients with coronary artery disease are advised to use coronary stenting as their primary revascularization method. This study aims to compare outcome of MACE after DEB Vs DES in treatment of patients within stent restenosis (ISR) presented with chest pain.

Methodology: The current study was Quasi experimental study carried out at the Department of Cardiology, MTI-HMC Peshawar for duration of six months from 21 April 2021 to 21 Nov 2021. In this study, 94 patients in DEB group and 94 patients in DES group were followed for 06 months to look for development of MACE.  All data was collected through a well-defined proforma. Data was entered on computer software SPSS version 22.

Results: In DEB group, 52 (55.3%) male patients and 42 (44.7%) female patients were recorded whereas in DES group, 57 (60.6%) male patients while 37 (39.4%) female patients were recorded. In DEB group, 15 (16.0%) patients were recorded with MACE whereas in DES group, 38 (40.4%) patients were recorded with MACE.

Conclusion: Our study showed that DEB is superior to DES in the management of in-stent restenosis and results in fewer major adverse cardiovascular events (MACE), so DEB may be considered as a treatment option for CAD patients admitted to our setting in in order to reduce mortality and morbidity associated to restenosis in such patients.
Comparison of Outcomes of Different Balloon Sets in Patients undergoing Percutaneous Transvenous Mitral Commissurotomy – Bigger and Differ is Better!
Authors: Tariq Farman Muhammad , Hashim Muhammad , Khan Naveedullah , Saghir Tahir
Published: March 2023

Background: Although the Inoue balloon technique is said to be more popular worldwide for PTMC in those who have severe MS, the Bonhoeffer multi-track (double balloon technique) system is used in our center. On the other hand, it is unknown which balloon set size will produce the best results. The current study's objective is to assess the efficacy of different balloon sets utilized in symptomatic patients with moderate to severe mitral stenosis (MS) following percutaneous transvenous mitral commissurotomy (PTMC).

Methodology: There were 203 consecutive patients. In 154 patients, a 14x14mm balloon set was used, and in the other 49 patients, a 14x16mm balloon set. PTMC was deemed successful when MVA 1.5 cm2 was attained with just minimal MR. Patients with valve areas less than 1.5 cm2 and more severe MR are regarded as failed.

Results: With a 14x16mm balloon set, post-procedure examination revealed noticeably better accomplishment in the valve area (2.960.84 cm2 versus 3.260.95 cm2; P=0.024). With a 14x16mm balloon set, a tendency towards a lower post-procedure mean pressure gradient across the mitral valve was seen (6.052.19 mmHg versus 5.472.24 mmHg; P=0.107). There was no discernible change in post-procedure MR, tamponade, or procedural failure. However, there was no significant statistical difference in the treatment efficacy between the groups (87.7% with a 14x16mm balloon set versus 77.9% with a 14x14mm balloon set; P=0.153).

Conclusion: A 14x16 mm balloon set might be a better and safer option, particularly for taller and older patients with larger annuli.
Left Main Coronary Artery Stenosis following Bentall Procedure: A case report.
Authors: Hameed Hannah , Anne John Tara , Tahirkheli Mashal , Cannon Bruce , Ellen White Julie , Zafar Hussnain , Baig M Almas , Sani Zarrar , Chohan Amad , Weitzel Ann-Marie , Razaq Humza , Siddiqi Alysha , Ali Mehak , Rizvi Ilsa , Ahmad Arslan , Muzaffar Bireera , Batool Sakina , Imtiaz Karamat Riyan , Manzoor Amjad Qasim , Karim Adil , Tahirkheli Naeem
Published: March 2023

Since its introduction, Bentall procedure has remained the standard of care for management of ascending aortic aneurysms with associated aortic valve pathologies. It involves replacement of aortic root, ascending aorta and the aortic valve, using a hybrid vascular graft with built in valves. The openings of the main coronary arteries are then rejoined with the graft. The procedure has satisfactory long term survival rate. However, there are some complications including graft infection, stroke from dislodged plaques and coronary insufficiency due to kinking of the reconnected main coronary arteries.

Here, we report a rare and life-threatening complication following Bentall procedure. A 76-year-old female developed left main stenosis following Bentall procedure, successfully treated with percutaneous coronary intervention (PCI). We discuss various etiologies and treatment options for this complication. We recommend routine surveillance with coronary angiography at six months post Bentall.
Recurrent coronary spasm presenting as acute STEMI; To stent or not to stent?
Authors: Ullah Abid , Keshavarzi F , Fraser D
Published: March 2023

Coronary artery spasm is a relatively uncommon cause of ST segment elevation myocardial infarction. However, the clinical presentation and electrocardiographic findings are remarkably similar to STEMI secondary to plaque rupture.

Recurrent presentation with coronary vasospasm as STEMI presents a unique clinical dilemma especially if they present to different centers where the previous history is not well known. Management in the acute settings continue to pose significant challenges in these acutely unwell patients.

We describe and explore a similar clinical situation in which a patient with severe recurrent STEMI presentations was found to have coronary artery vasospasms.

The case was twice misinterpreted as having plaque rupture STEMI leading to percutaneous coronary intervention and then further difficulties in long term management in view of need for long term antiplatelet and suspected association of eosinophilia with coronary vasospasm which in turn can be caused by Aspirin.
Analisis dan Penerapan Tiga Elemen Sistem Pembelajaran pada Era Industri 4.0 di Universitas Pembinaan Masyarakat Indonesia
Authors: Tampubolon Khairuddin , Elazhari Elazhari , Lumban Batu Fider
Published: March 2023

Pada Tahun 2018 ini merupakan Era Industri 4.0, yaitu disebut juga dengan Cyber Phisical, dimana cyber pada era sebelumnya adalah sosok yang tidak nyata pada dunia internet dan pada era industri 4.0, cyber telah memilki sosok atau dapat diketahui identitasnya walaupun dia sembunyikan atau disamarkan, hal ini disebabkan data individu pemakai jasa jaringan internet telah terekam oleh operator penyedia jaringan internet dan juga data statistik negara. Kemudian era industri 4.0 ini juga merupakan era wireless yaitu pengendalian sisitem operasional tidak lagi menggunakan kable akan tetapi dapat dilakukan melaui wireless (dengan media udara). Metode Penelitian ini menggunakan pendekatan kuantitatif dengan mengkaji fakta-fakta yang telah terjadi serta semua data dan informasi diwujudkan dalam bentuk angka, dengan analisis statistik parametrik. Informasi yang menyangkut variable dalam penelitian ini diperoleh dari responden yang ditransper dalam bentuk angka-angka kemudian dianalisis dengan exel word office 2010 dan ditampilkan dalam bentuk tabel dan diagram. Tujuan Penelitian ini adalah untuk menganalisis apakah mahasiswa UPMI Medan mengetahui akan hadirnya Era Industri 4.0 dan elemen Era Industri 4.0, dan dari hasil penelitian penulis menemukan 80 % Mahasiswa tidak mengetahui kehadiran Industri 4.0 dan 20 % lagi mengetahunya. Kemudian hasil Analisis tentang mengetahui Elemen Industri 4.0, mahasiswa UPMI , 13,33 mengetahui dan 86,67 tidak mengetahuinya. Selanjutnya penulis melakukan sosialisasi dan menerapkan sistem pengajaran berbasis Era Industri 4.0 terhadap mahasiswa melalui tiga Unsur Metode Pembelajaran yaitu: 1. Pembekalan Ilmu dan Motivasi, 2. Penerapan Ilmu/ Praktek, 3. Pelatihan Attitude yang baik.Keyword: Cyber, Cyber Phisical, Unsur Pembelajaran.
POLA PENGGUNAAN OBAT PERKEMIHAN CYSTITIS PADA RAWAT INAP KUCING DI MAKASSAR PET CLINIC PADA TAHUN 2021
Authors: Thahir Zakiah , Hylines Nora Saputri
Published: March 2023

Cystitis adalah infeksi pada kandung kemih.Tidak hanya pada manusia, penyakit infeksi saluran perkemihan juga bisa terjadi kepada hewan terkhususnya kucing yang sering disebut Feline Idiopatic Cystitis (FIC). Tujuan dari penelitian ini adalah untuk mengetahui pola penggunaan obat perkemihan Cystitis (FIC) pada pasien rawat inap kucing di Makassar Pet Clinic pada tahun 2021. Metode penelitian ini adalah deskriptif dengan mengumpulkan data dari rekam medis pasien yang menderita Cystitis pada tahun 2021.Hasil penelitian menunjukkan bahwa pola penggunaan obat cystitis pada hewan kucing sudah sesuai dengan terapi obat pada veterinaria.selain penggunaan obat kimia seperti antibiotik golongan sefalosforin,ampicillin,obat muntah ondansetron,metoclopramide,antiinflamasi seperti dexametason dan meloxicam,antipendarahan phytomenadion serta vitamin dan glucosamine,Ada juga pengobatan herbal yang diberikan yaitu herbal yunnan baiao, ba zhen san dan hua shi san,adapun dari 69 pasien yang rawat inap sebanyak 20 pasien yang harus memerlukan tindakan pemasangan kateter
БЕЛЕЖКИ ЗА ЦЪРКОВНАТА ОРГАНИЗАЦИЯ НА БЪЛГАРИЯ СЛЕД ПОКРЪСТВАНЕТО
Authors: Cheshmedzhiev Dimo
Published: March 2023

The article examines some questions regarding the initial eparchial division of the Bulgarian Church. An attitude is taken, both on the issue of the localization and identification of some of the dioceses soon after the Christianisation of Bulgaria, and on the question of control over them. The existing ideas in the historiography about direct control of the Patriarchate of Constantinople over part of the Bulgarian dioceses are rejected.
ZAKON SUDNYJ LYUDEM, ZAPOVEDI SVYATYCH OTEC AND VITICULTURE IN GREAT MORAVIA
Authors: Stankov Rostislav
Published: March 2023

The paper deals with the articles of the Zakon sudnyj lyudem (ZSL) and Zapovedi svyatych otec (ZSO), which are considered evidence of a developed viticulture in Great Moravia. The problem of the origin of ZSL and ZSO is also discussed, since some authors (J. Vašica) dispute their Bulgarian origin and refer them to the texts of the Moravian mission of Cyril and Methodius. The analysis of Vašica’s argumentation allows to reject the Moravian hypothesis of origin for ZSL and ZSO. Texts like ZSL and ZSO could not have come into being during the Moravian mission and for that reason cannot serve evidence of a developed viticulture in Great Moravia, regardless of its location.
Methylene blue chromoendoscopy is more useful in detection of intestinal metaplasia in the stomach than mucosal pit pattern or vessel evaluation and predicts advanced Operative Link on Gastric Intestinal Metaplasia stages
Authors: Wasielica-Berger Justyna , Rogalski Pawel , Pryczynicz Anna , Swidnicka-Siergiejko Agnieszka , Dabrowski Andrzej
Published: March 2023

Background/Aims: Intestinal metaplasia (IM) of the stomach is a precancerous condition that is often not visible during conventional endoscopy. Hence, we evaluated the utility of magnification endoscopy and methylene blue (MB) chromoendoscopy to detect IM.Methods: We estimated the percentage of gastric mucosa surface staining with MB, mucosal pit pattern, and vessel visibility and correlated it with the presence of IM and the percentage of metaplastic cells in histology, similar to the Operative Link on Gastric Intestinal Metaplasia (OLGIM) stage.Results: IM was found in 25 of 33 (75.8%) patients and in 61 of 135 biopsies (45.2%). IM correlated with positive MB staining (p<0.001) and other than dot pit patterns (p=0.015). MB staining indicated IM with better accuracy than the pit pattern or vessel evaluation (71.7% vs. 60.5% and 49.6%, respectively). At a cut-off point of 16.5% for the MB-stained gastric surface, the sensitivity, specificity, and accuracy of chromoendoscopy in the detection of advanced OLGIM stages were 88.9%, 91.7%, and 90.9%, respectively. The percentage of metaplastic cells detected on histology was the strongest predictor of positive MB staining.Conclusions: MB chromoendoscopy can serve as a screening method for detecting advanced OLGIM stages. MB mainly stains IM areas with a high concentration of metaplastic cells.
MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage, curbing signaling intensity for proper bone anabolism
Authors: Chu Tsz Long , Chen Peikai , Yu Anna Xiaodan , Kong Mingpeng , Tan Zhijia , Tsang Kwok Yeung , Zhou Zhongjun , Cheah Kathryn Song Eng
Published: March 2023

Bone homeostasis is regulated by hormones such as parathyroid hormone (PTH). While PTH can stimulate osteo-progenitor expansion and bone synthesis, how the PTH-signaling intensity in progenitors is controlled is unclear. Endochondral bone osteoblasts arise from perichondrium-derived osteoprogenitors and hypertrophic chondrocytes (HC). We found, via single-cell transcriptomics, that HC-descendent cells activate membrane-type 1 metalloproteinase 14 (MMP14) and the PTH pathway as they transition to osteoblasts in neonatal and adult mice. Unlike Mmp14 global knockouts, postnatal day 10 (p10) HC lineage-specific Mmp14 null mutants (Mmp14ΔHC) produce more bone. Mechanistically, MMP14 cleaves the extracellular domain of PTH1R, dampening PTH signaling, and consistent with the implied regulatory role, in Mmp14ΔHC mutants, PTH signaling is enhanced. We found that HC-derived osteoblasts contribute ~50% of osteogenesis promoted by treatment with PTH 1–34, and this response was amplified in Mmp14ΔHC. MMP14 control of PTH signaling likely applies also to both HC- and non-HC-derived osteoblasts because their transcriptomes are highly similar. Our study identifies a novel paradigm of MMP14 activity-mediated modulation of PTH signaling in the osteoblast lineage, contributing new insights into bone metabolism with therapeutic significance for bone-wasting diseases.
Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export
Authors: Qiao Yulong , Sun Qiang , Chen Xiaona , He Liangqiang , Wang Di , Su Ruibao , Xue Yuanchao , Sun Hao , Wang Huating
Published: March 2023

Skeletal muscle stem cells (also known as satellite cells [SCs]) are essential for muscle regeneration and the regenerative activities of SCs are intrinsically governed by gene regulatory mechanisms, but the post-transcriptional regulation in SCs remains largely unknown. N(6)-methyladenosine (m6A) modification of RNAs is the most pervasive and highly conserved RNA modification in eukaryotic cells; it exerts powerful impact on almost all aspects of mRNA processing that is mainly endowed by its binding with m6A reader proteins. In this study, we investigate the previously uncharacterized regulatory roles of YTHDC1, an m6A reader in mouse SCs. Our results demonstrate that YTHDC1 is an essential regulator of SC activation and proliferation upon acute injury-induced muscle regeneration. The induction of YTHDC1 is indispensable for SC activation and proliferation; thus, inducible YTHDC1 depletion almost abolishes SC regenerative capacity. Mechanistically, transcriptome-wide profiling using LACE-seq in both SCs and mouse C2C12 myoblasts identifies m6A-mediated binding targets of YTHDC1. Next, splicing analysis defines splicing mRNA targets of m6A-YTHDC1. Furthermore, nuclear export analysis also leads to the identification of potential mRNA export targets of m6A-YTHDC1 in SCs and C2C12 myoblasts;interestingly, some mRNAs can be regulated at both splicing and export levels. Lastly, we map YTHDC1 interacting protein partners in myoblasts and unveil a myriad of factors governing mRNA splicing, nuclear export, and transcription, among which hnRNPG appears to be a bona fide interacting partner of YTHDC1. Altogether, our findings uncover YTHDC1 as an essential factor controlling SC regenerative ability through multifaceted gene regulatory mechanisms in mouse myoblast cells.
Approach for the Management of Indefinite-for-neoplasia Lesions Detected on Gastric Mucosal Biopsy
Authors: Ryu Dae Gon , Choi Cheol Woong
Published: March 2023

Indefinite-for-neoplasia is an expression used to describe lesions in which carcinoma or dysplasia cannot be clearly and conclusively established via biopsy. Gastric indefinite-for-neoplasia may represent a reactive change secondary to inflammation in some patients; however, some lesions are eventually diagnosed as dysplasia or carcinoma. Follow-up endoscopic biopsy is commonly performed in patients with gastric indefinite-for-neoplasia lesions. Nonetheless, patients may undergo resection based on a high index of clinical suspicion for dysplasia or carcinoma based on endoscopic findings. Accurate target biopsies of the lesion and effective communication with pathologists are required to improve diagnostic accuracy and avoid unnecessary re-examinations. It is important to establish endoscopic findings useful in differentiating lesions that require resection. In this review, we describe the approach for the management of indefinite-for-neoplasia lesions detected on gastric mucosal biopsy and the characteristics of lesions that require resection.
Effects of stumping on fine root architecture, growth, and physiology of Hippophae rhamnoides
Authors: Wang Haoyue , Qi Wei , Guo Yuefeng , Xu Yajie
Published: March 2023

Background

Fine roots are vital to a plant’s ability to absorb water and nutrients. Stumping is a practice that may encourage fine root growth and the rapid recovery of decaying Hippophae rhamnoides plants. However, the effect of stumping on the fine roots and physiological indices is still unknown. The differential indices between stumped forests and non-stumped forests must also be defined.

Methods

We recorded the changes in the fine roots of structure H. rhamnoides one year after stumping. Using single factor analysis of variance and general linear models we comprehensively analyzed the number of root tips and the plant’s growth and physiological indices in response to stumping. Partial least squares discriminant analysis (PLS-DA) was used to compare fine root growth and physiological indices with and without stumping in order to identify the differential indices.

Results

The proportion of root tips in the vertical layers at 30–40 cm and 40–50 cm and in the horizontal layers at 60–80 cm and 80–100 cm, increased after stumping by 1.85%, 2.60%, 1.96% and 4.32%, respectively. In the 0–50 cm soil layer, the fine root dry weight rose by 27.6% compared with the control, which was not significant. However, other indices were significantly different from the control. The proportions in the growth indices in the 30–40 cm and 40–50 cm layers increased after stumping. Stumping had a significant, negative effect on proline and malondialdehyde content, which dropped by 40.95% and 55.32%, respectively, indicating that the harms caused by these two chemicals was alleviated. Stumping had a significant positive effect on root activity and soluble sugar contents, which increased by 68.58% and 36.87%, respectively, and improved the growing ability of fine roots. PLS-DA revealed that malondialdehyde, soluble sugars, root density, and the number of root tips ranked from having the least to greatest effect on the classification of stumping and no-stumping.

Conclusions

The process of stumping may promote fine roots growth in H. rhamnoides, and is favorable for their longitudinal development. The fine root growing indices of H. rhamnoides responded positively to this process. Stumping promotes root activity and the creation of soluble sugar to maintain the growth and development of fine roots. It also inhibits the negative effects of proline and malondialdehyde on fine roots. Our study showed that the differential physiological indices were more important for classification than the differential growing indices.
Design of a 12 bit SAR ADC with Self-Calibration
Authors: Guan Yu , Luo Pan , Gou Bo
Published: March 2023

Successive approximation analog-to-digital converter (SAR-ADC) are widely used in intelligent sensing fields due to it’s low power consumption, medium and high precision and such characteristics. Traditional binary SAR ADC have non-ideal factors such as DAC capacitor array mismatch and comparator offset, which severely limit it’s performance. Therefore, a self-calibration method for non-ideal factors is proposed in this work, and theoretical derivation and simulation analysis are carried out. A 12-bit non-binary SAR ADC with self-calibration is designed based on the TSMC 40nm CMOS process, which reduces the capacitance area, improves the conversion accuracy, and eliminates most of the errors caused by non-ideal factors. Simulation results show that the ADC’s SNDR is 72.01dB, and INL within +1.2/-1LSB, meets most of the market requirements.