bluuebunny/crossref_metadata_2025 huggingface dataset:
Left-Sided Prosthetic Valve Dysfunction and Gastrointestinal Bleeding Short Title: Prosthetic Valve Dysfunction and GI Bleeding
Authors: Hussain Kifah , Kattoor Ajoe John , Liu Bolun , Parfieniuk Agata , Achebe Ikechukwu , Doukky Rami
Published: March 2022

The association between left-sided prosthetic valve (PV) dysfunction and gastrointestinal (GI) bleeding is not well established. In a retrospective cohort of patients with left-sided prostheses, we identified those who experienced one or more GI bleeds. The latest or chronologically closest echocardiogram to the GI bleed was analyzed by a blinded investigator for PV dysfunction. Among 334 unique patients, 166 had aortic prostheses, 127 had mitral prostheses, and 41 had both. A total of 58 (17.4%) subjects had GI bleeding events. Patients in the “GI Bleed” group had higher mean ejection fraction (56 ± 14% vs. 49 ± 15%; P = 0.003) and higher prevalence of hypertension, end-stage renal disease, and liver cirrhosis compared to the “No GI Bleed” group. There was a higher prevalence of moderate or severe PV regurgitation in the GI Bleed vs. No GI Bleed group (8.6% vs. 2.2%; P = 0.027). Moderate or severe prosthetic valve regurgitation was independently associated with GI bleeding (odds ratio, 6.18; 95% confidence interval, 1.27–30.05; P = 0.024), after adjusting for ejection fraction, hypertension, end-stage renal disease and liver cirrhosis. Paravalvular regurgitation was associated with a higher incidence of GI bleeding compared to transvalvular regurgitation (35.7% vs. 11.9%; P = 0.044). The prevalence of PV stenosis was similar between the GI Bleed and No GI Bleed groups (6.9% vs. 5.8%; P = 0.761). In conclusion, among patients with predominantly surgically placed PV, moderate to severe left-sided PV regurgitation was independently associated with GI bleeding. PV stenosis was not associated with GI bleeding.
Enhancement of the Mechanical Properties of Carbon Fiber Sandwich Structures Using Self-Healing Mechanism
Authors: Soliman Rasha
Published: March 2022

The interest of researchers to study self-healing materials has been increased as a result of their high ability in detecting and healing the occurred cracks and voids. Previous studies revealed that when a self-healing material is cracked due to thermal, mechanical or ballistic means, it has the ability to fully or partially self-heal the occurred crack and restore the material to its original functionality. Self-healing materials can be made from metals, polymers, ceramics and their composites. The main objective of this paper is to examine the effect of adding self-healing agents to carbon fiber composite sandwich structures. The mechanical behavior of the self-healing material was compared to the virgin material using the finite element method, where great variations in the mechanical properties were noted. By using the self-healing mechanism, an enhancement in carbon fiber composite material strength was attained.
Low awareness of venous thromboembolism (VTE) among neurosurgical hospitalized patients: a cross-sectional study
Authors: Lin Pan , Wiley James Allen , Tian Lingyun , Li Wan , Yang Qiuhong , Yang Haifan , Tan Xin , Gao Yijing , Li Weijuan , Luo Hui , Feng Xinyu , Li Yinglan
Published: March 2022

Background: Venous thromboembolism (VTE) including Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE), is a serious cause of patient morbidity and mortality in hospitals. Neurosurgical hospitalized patients have higher rates of immobility and bed rest, thus increasing their risk of developing VTE. This highlights the need for their thromboprophylaxis regimens. Patients'awareness of VTE is essential for promoting strategies such as early ambulation and encouraging self-assessment and self-reporting of VTE signs and symptoms. This study evaluated neurosurgical hospitalized patients’ awareness of VTE and explored the influencing factors to provide a theoretical basis for nursing intervention. Methods: We selected one tertiary level hospital in Hunan Province and randomly sampled eligible patients from each five neurosurgical units. We conducted a cross-sectional survey of the hospitalized patients of neurosurgery using the VTE knowledge questionnaire, and the influencing factors were analyzed using SPSS 26.0. Results: A total of 386 neurosurgical hospitalized patients completed the survey. The score of VTE knowledge in neurosurgical hospitalized patients was 13.22 (SD=11.52). 36.0% and 21.2% of participants reported they had heard of DVT and PE, respectively. 38.9% of participants were unable to correctly identify any symptoms of VTE. The most frequently identified risk factor was ‘immobility or bed rest for more than three days’ (50.0% of participants), and 38.1% of patients agreed that PE could cause death. 29.5% of participants were unable to identify any prophylactic measures of VTE. The results of Negative Binomial Regression showed that the influencing factors of VTE knowledge in neurosurgical hospitalized patients were education level (P<0.004) and sources of information related to VTE, including nurses (95% CI=2.201-4.374, P<0.001), and family member/friend (95% CI=2.038-4.331, P<0.001), Internet/TV (95% CI=1.382-2.834, P＜0.001). Other sources included patient /pamphlet/poster /professional books (95% CI=492-3.350, P<0.001). Conclusions: This study demonstrates the lack of awareness of VTE among neurosurgical hospitalized patients. More attention must be paid to carrying out training on VTE knowledge according to different characteristics of neurosurgical hospitalized patients, so as to ensure safe and high-quality patient care.
Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants
Authors: Vecchio Claudia Del , Daniels Bethan Cracknell , Brancaccio Giuseppina , Brazzale Alessandra , Lavezzo Enrico , Ciavarella Constanze , Onelia Francesco , Franchin Elisa , Manuto Laura , Bianca Federico , Cianci Vito , Cattelan Annamaria , Dorigatti Ilaria , Toppo Stefano , Crisanti Andrea
Published: March 2022

Population testing remains central to COVID-19 control and surveillance, with countries increasingly using antigen tests rather than molecular tests. Here we describe a SARS-CoV-2 variant that escapes N antigen tests due to multiple disruptive amino-acid substitutions in the N protein. By fitting a multistrain compartmental model to genomic and epidemiological data, we show that widespread antigen testing in the Italian region of Veneto favored the undetected spread of the antigen-escape variant compared to the rest of Italy. We highlight novel limitations of widespread antigen testing in the absence of molecular testing for diagnostic or confirmatory purposes. Critically, in the presence of a variant that escapes antigen testing, following up a proportion of negative antigen tests with a molecular test is the optimal testing strategy. Together, these findings highlight the importance of retaining molecular testing for surveillance purposes, also in contexts where the use of antigen tests is widespread.
Liver cancer treatment using magneto plasmonic method by Fe3O4/Au-Ag@MoS2 nanoparticles
Authors: Seyedjamali Tina , Farahzadi Mohammadreza Kazem , Arabi Hossein
Published: March 2022

This study investigates the treatment of liver cancer by the magnetic hyperthermia approach and nanoparticles including \({Fe}_{3}{O}_{4}\) core with gold, silver alloy shell, and \({MoS}_{2}\) coating. Optical properties of these nanoparticles within the tumor, including the extinction coefficient and surface plasmon peak (SPR) as a function of size, structure, different compositions, and thickness are also investigated using the effective medium theory. Moreover, the impact of temperature distribution was assessed through the analytical modeling of alternating current (AC) magnetic field. The results of this study demonstrated that nanoparticles with a compound of \(F{e}_{3}{O}_{4}-{Au}_{0.25}{Ag}_{0.75}@{MoS}_{2},\) a 3 nm thick cover of gold-silver alloy, and 3 layers of \({MoS}_{2}\) have the best coefficient of extinction and SPR in the biological window. The gold-silver alloy improved the extinction coefficient and, at the same time, prevented the accumulation of magnetic nanoparticles. Since the gold-silver alloy alone cannot function within the range of biological windows, \({MoS}_{2}\) was used, which increased the extinction efficiency at higher wavelengths. Examination of the temperature distribution in the tumor for the proposed alloy compound indicated that after a short time from the start of irradiation, the tumor temperature reaches 45 ° C. Also, the temperature distribution within the tumor tissue reached its maximum value at the center of the tumor and decreased dramatically as getting away from the center. The use of magnetic hyperthermia enabled localized delivery of therapeutic dose to malignant tumors; hence, exhibiting superior performance/efficiency over the photothermal method.
Ultrafast Charge Generation in a Homogenous Polymer Domain
Authors: Meng Ruixuan , Zhu Rui
Published: March 2022

Efficient charge generation contributes greatly to the high performance of organic photovoltaic devices. The mechanism of charge separation induced by heterojunction has been widely accepted. However, how and why free charge carriers can generate in homogenous polymer domains remains to be explored. In this work, the extended tight-binding SSH model, combined with the non-adiabatic molecular dynamics simulation, is used to construct the model of polymer array in an applied electric field and simulate the evolution of an excited state. It is found that under a very weak external electric field \(5.0\times {10}^{-3}V/\text{Å }\), the excited state can evolve directly into spatially separated free charges at femtosecond scale, and the quantum efficiency is up to \(97\%\). The stacking structure of the polymer array leads to intermolecular electron mutualization and form intermolecular coupling. This interaction tends to delocalize the excited states in organic semiconductors, competing with the localization caused by electron-phonon coupling. Excitons within the homogenous polymer domains have lower binding energy, less energy dissipation, and ultrafast evolution. Therefore, the initial excited state can evolve directly into free carriers under a very weak electric field. This finding provides a reasonable explanation for ultrafast charge generation in pure polymer phases and is consistent with the fact that delocalization always coexists with ultrafast charge generation. Moreover, the devices based on homogenous polymer domains are supposed to be stress-sensitive and performance-anisotropic since the above two interactions have contrary effects and work in perpendicular directions. This work is expected to bring inspiration for the design of organic functional materials and devices.
A Frontal Cryptococcal Abscess in an HIV-Negative Patient: A Case Report and Overview of Literature
Authors: Xiao Fang , He Lixia , Wu Zezhou , Yu Yanhong
Published: March 2022

Background: Cryptococcus has been occurring in an increasing number of immunocompetent individuals, with a worse response rate to available therapies as compared with classical immunosuppressive patients. Case presentation: Herein, we report a rare case of a cryptococcal brain abscess in an immunocompetent patient. This 25-year-old woman presented with a progressively worsening headache, a persistent fever, and a 2.4×2.2×2.0 cm frontal abscess. Cerebrospinal fluid (CSF) and blood cultures confirmed cryptococcal infection. She was administered standard antifungal treatment. The intracranial lesion shrunk and her clinical condition improved. However, medical therapy alone failed due to sustained high intracranial pressure during the consolidation phase and subsequent antibacterial treatment. Surgical excision confirmed a frontal abscess due to Cryptococcus neoformans. She had complete resolution following surgery. Conclusions: Although medical therapy alone may be effective for small abscesses (<2.5 cm), this case highlights that if the patient has persistently high intracranial pressure, a combined medical and surgical approach is optimal for disease management.
A Comprehensive Study on Phenolic Transition to Olive Oil from Fruits Depending on Malaxation Conditions and Ripening Degree
Authors: Delil Saliha Onur Sermet , ÖZKAN Gülcan , KARACABEY Erkan
Published: March 2022

Phenolics, in addition to color, flavor, nutritional value, and organoleptic properties, are mainly responsible for the oxidative stability of olive oil and change according to the degree of maturity and processes. This study, it was aimed to optimize the malaxation process using the response surface method in terms of oil yield and bioactive phenolic constituents, including total phenolic content, ortho-diphenol, and free radical scavenging activity of olive oils at three maturity stages. At all maturity stages, malaxation temperature and time were effective on the considered responses. The total phenolic content, ortho-diphenols, and free radical scavenging activity of the oil samples varied in a range of 86.11-338.94 (milligram gallic acid equivalent (GAE)/kg), 66.74-154.88 (mg GAE/kg), and 42.49–90.10%, respectively, depending on the malaxation conditions. Tyrosol, hydroxytyrosol, vanillic acid, vanillin, p-coumaric acid, ferulic acid, quercetin, and luteolin were the individual phenolics determined chromatographically in the olive oil samples, and their amounts varied to different extents depending on the malaxation conditions and maturity stages. The models show high predictive performance to explain the variation in the study. The optimum conditions for malaxation temperature and time for oil extraction from spotted, purple, and black fruits were 35°C/45 min, 33°C/44 min, and 35°C/24 min, respectively. In conclusion, our study proved that a moderate temperature level is sufficient to achieve the highest antioxidant phenolic content and oil yield together. These results could be economically valuable for producers and consumers.
Numerical and experimental study of the size effect on deformation behavior and quality of microembossed multi-channel structures
Authors: Tong Xu , Zheng Jun-Yuan , Fu M.W.
Published: March 2022

With an uptrend of product miniaturization and precision manufacturing, the microembossing process of sheet metal has been widely used, and the corresponding researches have been conducted from the aspects of both experimental and theoretical explorations. Many unknowns, however, remain, such as size effect and it-induced scatters of deformation behaviors and product qualities. In this research, the multi-channel structures with various thicknesses made by a microembossing system using pure copper sheets were employed as case studies. The crystal plasticity finite element method simulations and experiments were conducted to study the effects of grain size and sheet thickness on the process and product of microembossing in terms of load-stroke relation, dimensional accuracy, and surface quality. From both the experimental and numerical results, it is revealed that the grain size effect causes deviated load and non-uniformity in deformation. The dimensional accuracy designated by the variations in thickness and height is affected by both grain size and sheet thickness. As grain size increases, the thickness reduction becomes more dramatic, and the thinnest location is at the corner zone. The height of the channel bottom increases with grain size, while the peak height fluctuation due to grain size is relatively minor. In addition, various surface defects on the surface of the embossed multi-channel structure were observed, including microvoids and micro scratches on the sidewalls, and wrinkles and grooves on the peak and bottom surfaces. From the inner to outer of the structures, microvoids gradually change to micro scratches, which become denser and longer as grain size increases in 100 μm thick copper sheets and also more severe with the increasing sheet thickness. All of these enrich the understanding of sheet metal microembossing and facilitate design solution generation in the optimization of the microembossing process and the quality of the embossed structures.
Relative Accuracy of HWRF Reanalysis and a Parametric Wind Model during the Landfall of Hurricane Florence and the Impacts on Storm Surge Simulations
Authors: Rahman Md Arifur , Zhang Yu , Lu Lixin , Moghimi Saeed , Hu Kelin , Abodolali Ali
Published: March 2022

Prediction and reanalysis of storm surge rely on wind and pressure fields from either parametric tropical cyclone wind models or numerical weather model reanalysis, and both are subject to large errors during landfall. This study assesses two sets of wind/pressure fields for Hurricane Florence that made landfall along the Carolinas in September 2018, and appraises the impacts of differential structural errors in the two suites of modeled wind fields on the predictive accuracy of storm surge driven thereby. The first set was produced using Holland 2010 (H10), and the second set is the Hurricane Weather Research and Forecasting (HWRF) reanalysis created by the NWS National Centers for Environmental Prediction (NCEP). Each is validated using a large surface data set collected at public and commercial platforms, and then is used as input forcing to a 2-D coastal hydrodynamic model (Delft3D Flexible Mesh) to produce storm surge along the Carolina coasts and major sounds. Major findings include the following. First, wind fields from HWRF are overall more accurate than those based on H10 for the periphery of the storm, though they exhibit limitations in resolving high wind speeds near the center. Second, applying H10 to the best track data for Florence yields an erroneously spike in wind speed on September 15th when the storm reduced to a tropical depression. Third, HWRF wind fields exhibit a progressively negative bias after landfall, likely due to deficiencies of the model in representing boundary layer processes, and to the lack of assimilation of surface product after landfall for compensating for these deficiencies. Fourth, using HWRF reanalysis as the forcings to Delft3D yields more accurate peak surges simulations, though there is severe underestimation of surge along the shoreline close to the track center. The peak surge simulations by Delft3D are biased low when driven by H10, even though over several locations the H10 model clearly overpredicts surface wind speeds. This contrast highlights the importance of resolving wind fields further away from the center in order to accurately reproduce storm surge and associated coastal flooding.
Measurement of intramural tumor spread distance and determination of optimal distal resection margins after neoadjuvant radiotherapy for rectal cancer under naked eyes
Authors: Sun Ge , Ye Xiaolong , Zhang Hang , Furnee Edgar , Broens Paul , Trzpis Monika , Zheng Kuo , Lou Zheng , Gao Xianhua , Liu Lianjie , Hao Liqiang , Bai Chenguang , Zhang Wei
Published: March 2022

Background
It is not clear about the safe distance between the intra-operative resection line and the distal rectal tumor visible margin after preoperative radiotherapy. We aimed to investigate the furthest tumor intramural spread distance in fresh tissue to determine safe distal intraoperative resection margin length.
Methods
Twenty specimens of rectal cancer after preoperative radiotherapy were collected. Tumor intramural spread distances were defined between tumor visible margin and microscopic margin. Tumor visible margins in fresh specimen were identified during operation and were labeled with 5 − 0 sutures under naked eyes at distal 5, 6, 7 o’clock direction of visible margins right after removal of the tumor. Labels of suture were injected with nanocarbon particles by gauge 27 syringe after fixation with formalin. Longitudinal tissues were collected along three labels and stained with hematoxylin and eosin. The spread distance after formalin fixation was measured between the furthest intramural spread tumor cell and the nanocarbon under the microscope. Positive intramural spread distance meant the furthest tumor cell was distal to the nanocarbon, and negative value meant tumor cell being proximal to the nanocarbon. Tumor intramural spread distance in fresh tissue during operation was 1.75 times of tumor intramural spread distance after formalin fixation according to literature.
Results
At distal 5, 6 and 7 o’clock direction, seven (35%), five (25%) and six (30%) patients had distal tumor cell intramural spread distance > 0 mm. The median tumor cell intramural spread distance in fresh tissue during operation was − 0.9 (IQR, -4.8, 3.5) mm, 0 (IQR, -4.8, 3.1) mm and − 3.5 (IQR, -5.3, 5.3) mm, respectively. The maximal intramural spread distances in fresh tissue during operation were 8.75, 7 and 7 mm, respectively.
Conclusions
The intraoperative distance between the distal resection line and rectal tumor visible margin after radiotherapy should be around 1cm to ensure oncological safety.
Hilbert’s First Problem and the New Progress of Infinity Theory
Authors: Wang Xijia
Published: March 2022

In the 19th century, Cantor created the infinite cardinal number theory based on the "1-1 correspondence" principle. The continuum hypothesis is proposed under this theoretical framework. In 1900, Hilbert made it the first problem in his famous speech on mathematical problems, which shows the importance of this question. We know that the infinitesimal problem triggered the second mathematical crisis in the 17-18th centuries. The Infinity problem is no less important than the infinitesimal problem. In the 21st century, Sergeyev introduced the Grossone method from the principle of "whole is greater than part", and created another ruler for measuring infinite sets. At the same time, 16 the development of the infinity theory provides new ideas for solving Hilbert's first problem, and provides a new mathematical foundation for Cosmic Continuum Theory.
Characterization of an RNA binding protein interactome reveals the targetable post-transcriptional landscape of MYC-amplified medulloblastoma
Authors: Kameda-Smith Michelle , Zhu Helen , Luo EnChing , Venugopal Chitra , Xella Agata , Yee Brian , Xing Sansi , Tan Frederick , Fox Raymond , Brown Kevin , Adile Ashley , Bakhshinyan David , Chokshi Chirayu , Gwynne William , Subapanditha Minomi , Picard Daniel , Burns Ian , Moffat Jason , Fleming Adam , Hope Kristin , Provias John , Remke Marc , Lu Yu , Reya Tannishtha , Reimand Jüri , Wechsler-Reya Robert , Yeo Gene , Singh Sheila
Published: March 2022

Pediatric medulloblastoma (MB) is the most common solid malignant brain neoplasm, with Group 3 (G3) MB representing the most aggressive subgroup. MYC amplification is an independent poor prognostic factor in G3 MB, however, therapeutic targeting of the MYC pathway remains limited and alternative therapies for G3 MB are urgently needed. Here we show that the RNA-binding protein, Musashi-1 (MSI1) is an essential mediator of G3 MB in both MYC-overexpressing mouse models and patient-derived xenografts. MSI1 inhibition abrogates tumor initiation and significantly prolongs survival in both models. We identified binding targets of MSI1 in normal neural and G3 MB stem cells and then cross referenced these data with unbiased large-scale screens at the transcriptomic, translatomic and proteomic levels to systematically dissect its functional role. Comparative integrative multi-omic analyses of these large datasets reveal cancer-selective MSI1-bound targets sharing multiple MYC associated pathways, providing a valuable resource for context-specific therapeutic targeting of G3 MB.
Effects of CoFlow-Jet Active Flow Control on Airfoil Stall
Authors: Yazdani Shima , Salimipour Erfan , Salimipour Ayoob , Sheremet Mikhail , Ghalambaz Mohammad
Published: March 2022

An active flow control method as CoFlow-Jet (CFJ) is implemented on the NACA 0024 airfoil at the chord-based Reynolds number of 1.5×105. For this purpose, an in-house solver based on the Reynolds averaged Navier-Stokes equations in two-dimensional, incompressible and unsteady form with the SST-k-ω turbulence model is prepared. Several levels of jet momentum coefficient (Cμ) are studied to achieve a proper momentum coefficient for each angle of attack (α). The findings demonstrate that at Cμ=0.06, the lift coefficients at low attack angles (up to α =15̊) dramatically increase. Furthermore, the dynamic stall at the given Reynolds number and with the lowered frequency of 0.15 is explored. In the instance of Cμ=0.07, the lift coefficient curve does not show a noticeable stall feature compared to Cμ=0.05, suggesting that a more powerful stronger jet can entirely control the dynamic stall. The impact of raising the Reynolds numbers from 0.5 × 105 to 3 × 105 on this active flow control is also explored. The lift coefficient improves at all Reynolds numbers studied as Cμ increases, with the highest performance achieved at α = 15̊.
The impact of indirect notification of cancer diagnosis on postoperative esophageal cancer patients in stage T3: A propensity score matching analysis
Authors: Yu Minhao
Published: March 2022

Background: Chinese doctors are required to inform cancer diagnosis to patients’ direct relatives rather than patients themselves. Patients may be hidden disease from their family members, and it may cause some serious results. Therefore, we carried out a retrospective study to evaluate whether indirect notification of cancer diagnosis can impact the prognosis of postoperative esophageal cancer patients in stage T3.Methods: We selected postoperative T3 esophageal cancer patients hospitalized from June 2015 to December 2016 as research subjects, and divided them into a direct-notification group and an indirect-notification group. Several variables are allowed for evaluating 36-month progress-free survival of the two groups. Propensity score matching analysis were used to adjust selection bias.Results: There were 72 patients enrolled in the study. Sex and indirect notification of cancer diagnosis were significantly predicted poor survival while stage, pathological differentiation, education background and age were not after propensity score matching analysis (P=0.02, 0.02, 0.30, 0.18, 0.07, 0.05, respectively). Cox multivariate regression analysis shows male and indirect notification of cancer diagnosis independentlly predict poor survival of progress-free survival of esophageal cancer at postoperative T3 stage (harzard ratio = 0.264, 95% confidence interval: 0.099-0.703, P=0.01; harzard ratio =2.823, 95% confidence interval: 1.360-5.861, P=0.01, respectively). Conclusions: Indirect notification of cancer diagnosis is an important negative predictors of postoperative esophageal cancer patients' progress-free survival.
Identification of hub genes and their clinical value for predicting the development of prostate cancer from benign prostate hyperplasia by bioinformatic analysis
Authors: Wu Gang , Chen Xi , Ma Junjie , Xu Chengdang , Wang Licheng , Yao Yicong , Wang Xinan , Zi Tong , Bian Cuidong , Wu Denglong
Published: March 2022

Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases. However, the genetic association between them is still unclear. Gene Expression Omnibus (GEO) database can help determine the differentially expressed genes (DEGs) between BPH and PCa. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were utilized to find pathways DEGs enriched. The STRING database can provide a protein–protein interaction (PPI) network, and find hub genes in PPI network. GEPIA can be used to analyze expression and survival data for hub genes. R software was used to progress regression analysis. Finally, the results were tested in other databases, clinical samples and PCa cells. Fifteen up-regulated and forty-five down-regulated genes were found from GEO database. Seven hub genes were found in PPI network. The hub gene expression was tested on The Cancer Genome Atlas (TCGA) data. Except CXCR4, all hub genes expressed differently between tumor and normal samples. Exclude CXCR4, other hub genes have diagnostic value in predicting PCa and their mutations can cause PCa. The expression of CSRP1, MYL9 and SNAI2 changed in different tumor stage. CSRP1 and MYH11 could affect disease-free survival (DFS). Same results reflected in different databases. The expression and function of MYC, MYL9, and SNAI2, were validated in clinical samples and PCa cells. In conclusion, seven hub genes among sixty DEGs can be achievable targets for predicting which BPH patients may later develop PCa.
The identification of key genes and Pathways in Osteoarthritis-related Inflammatory Synoviocytes by Bioinformatics Analysis
Authors: Wu Peng , Li Mingchao , Shi XiaoQing , Jie Lishi , Mao Jun , Yin Songjiang
Published: March 2022

Background: Osteoarthritis (OA) is characterized as sustained synovial inflammation and progressive cartilage degradation, in which inflammatory synoviocytes play a pivotal role. The purpose is to define key genes and relevant pathways in inflammatory synoviocytes in vivo and vitro. In the current study, the differentially expressed genes from GSE46750 and GSE82107 gene data were overlapped to show the intersection genes in inflammatory synoviocytes in vivo, and from GSE49604 and GSE82107 gene data were used in vitro. Meanwhile, the enrichment analyses and protein-protein interaction were confirmed in the two overlapped DEGs, respectively. Subsequently, meta- enrichment analysis was also performed to discriminate the differences between synoviocytes in vivo and vitro. Finally, analysis of miRNA network and associated pathways in overlapped genes in vitro and vivo were also finished. Results: A total of 36 intersection DEGs, enriched in ‘cell response to oxidative stress’, ‘response to lipopolysaccharide’ and ‘tumor necrosis factor signaling pathway’, were identified in inflammatory synoviocytes in vivo, as well as 35 overlapped DEGs, enriched in ‘mineral absorption’, ‘response to lipopolysaccharide’ and ‘oxidation-reduction process’, were identified in vitro. Additionally, in the meta-enrichment analysis, the results suggested that DEGs in vivo and vitro collectively enriched in ‘immune response’, ‘response to LPS’, ‘chemokine signaling pathway’ and ‘TNF signaling pathway’. However, the ‘regulation of macrophage activation’, ‘positive regulation of neutrophil chemotaxis’, ‘positive regulation of leukocyte chemotaxis’ and ‘leukocyte migration’ were individually enriched in the DEGs from inflammatory synoviocytes in vivo. Finally, the two comparison cohorts shared five intersection genes, including C-X-C chemokine ligand (CXCL) 2, CXCL5, chloride intracellular channel (CLIC) 6, solute carrier family 7 member 2 (SLC7A2) and chromosome 15 open reading frame 48 (C15orf48), and predicted miRNAs mainly enriched in transforming growth factor (TGF)-β, Ras and Wnt signaling pathway. Conclusion: The study demonstrated that OA-related inflammatory synoviocytes is associated with immune response, TNF signaling pathway, chemokine signaling pathway and oxidation-related process. However, compared to inflammatory model in vitro, in OA joint, the synovial inflammation is more complicated, maybe involved neutrophil recruitment, monocyte migration, and macrophage activation. Additionally, the current study also shown that some key genes CLIC6, CXCL2, CXCL5, SLC7A2 and C15orf48, may be related to the disease progression and produce effect as potential therapeutic approach in OA.
Relationship between insulin resistance and endometrial cancer was revealed by gene screening
Authors: Ding Dou-Dou , Zhou Quan , He Ze , He Hong-Xia , Zuo Man-Zhen
Published: March 2022

Background: Epidemiological studies have found, the occurrence of endometrial cancer (EC) is closely related to metabolic diseases, and insulin resistance (IR) plays an important role in the pathogenesis of endometrium, but the specific pathogenesis is still unclear. The purpose of this study is to reveal the relationship between insulin resistance and endometrial carcinoma. Methods: We analyzed one endometrial carcinoma database (GSE106191) and one insulin-resistant database (GSE63992), with GEO database and Venny online analysis tool, and P-value< 0.05 was thought about as statistically significant, then, we found an add-up to 148 different genes. Functional enrichment analysis of these genes using DAVID showed that they were participated in transcription factor activity, signaling pathways and response to factors, etc. Then used Cytoscape to establish Protein-Protein Interaction network, and got 25 hub genes. Then further analyzed the expression differences, histological differences, survival analysis, immune infiltration and genetic alteration of 25 hub genes.Results: Of the 25 hub genes, 9 hub genes (KLF5, BRD4, E2F2, LYN, HES1, YY1, IGSF3, TRAF3 and GJB3) were over-expressed in endometrial carcinoma, 11hub genes (TRO, NEURL2, PTEN, RARA, RYBP, OGT, FBXW7, PIK3C3, PIK3C2B, ING3 and DDX58) were under-expressed, and there were no significant difference among 5 hub genes (MYL12A, RAD21, TGFBRAP1, IRAK2 and PTPN1).The results showed that the survival time of patients expressing OGT, IGSF3, TRO, NEURL2 and PIK3C2B may be significantly and closely related to EC, and the percentage of gene changes of five central genes ranged from 3% to 10% of a single gene, was also related to the infiltration of seven kinds of immune cells in endometrial carcinoma.Conclusion: The five key genes (OGT, IGSF3, PIK3C2B, TRO and NEURL2) may be involved in immune infiltration in the progression of endometrial carcinoma, and there is also a certain mutation probability in gene mutation. Insulin resistance may be a trigger in the pathogenesis of endometrial cancer.
The Mirror Reversal Mechanism on Black Hole Collapse and Singularity Eruption in Cosmic Continuum
Authors: Wang Xijia
Published: March 2022

In the Big Bang Theory and the Black Hole Theory, the existing laws of physics all fail atthe singularity, and the singularity has become a blind spot in the existing scientific theories. In Cosmiccontinuum, the cosmic system collapse into a Schwarzschild black hole under the action of a stronggravitational field, and the Planck spheres at the center of the black hole continues to collapse into darkmass bodies, forming dark celestial body and singularity. The Schwarzschild radius is the upper limitof a black hole, and the Planck sphere is the lower limit of a black hole. The singularity is theconversion point between the old and new cosmic systems. The singularity erupts the Planck spheresunder the action of a strong gravitational field, and the Planck spheres expands outward to form a newcosmic system. The Planck sphere is both the end of the old cosmic system and the starting point of thenew cosmic system. The black hole collapse and the singularity eruption are mirror images of eachother. The Planck sphere is the front of the mirror, and the singularity is the back of the mirror.
Effect of Intensity-Dependent Couplings and the atomic dissipation on The Interaction of Two Three-Level Atoms and Two Modes of Radiation Field
Authors: Obada A.-S. F. , Rabea R. N , Ahmed M. M. A. , Khalil E. M. , El-Deberky M. A.
Published: March 2022

In this article the effect of intensity-dependent coupling and the atomic dissipation on the interaction of a pair of three-level atoms in the Ξ configuration with a bi-mode cavity field are studied. The solution of the proposed model is obtained in the resonance case. Some statistical quantities are discussed to discover the characteristics of the model. With different nonlinearity functions, the population inversion and the photon number dynamics, which display the phenomenon of collapses and revivals are discussed. The non-classical effects by examining the Mandel Q-parameter are considered. The amount of correlation between the two atoms and the field is estimated by analyzing the results of the fidelity.
Challenges to residents’ lives in urban areas in the context of the COVID-19 pandemic in Vietnam
Authors: Le Quan , Thuy Cu Thanh
Published: March 2022

This study designed the challenges faced by urban dwellers in Vietnam during the outbreak of the COVID-19 pandemic. The challenges facing people are shown through research indicators such as people’s income, expenditures, unemployment, and government support. The study collected data through the survey of 352 people (Survey respondents represent areas heavily affected by the COVID-19 pandemic in Vietnam, such as Bac Giang Province, Da Nang City, Hanoi Capital, and Ho Chi Minh City, Binh Duong Province). Among the 352 people surveyed, 206 lived in urban areas and 146 in rural and suburban areas. Differential analysis and multivariate regression were used to analyze the research data. The findings of the study show that the incomes of people in urban areas compared to those in rural areas varied before and after the COVID-19 pandemic. Additionally, the study shows that the income and expenditures of people in urban areas declined before and after the outbreak of the COVID-19 pandemic. The findings show different levels of impact of factors on income in urban areas affected by the COVID-19 pandemic. Government support factor has the greatest impact on people’s income in urban areas of Vietnam (Standardized coefficients = 0.502).
Fast Catalytic Pyrolysis of Tetradecanoic Acid: Formation of Ketones as Intermediate Compounds in the Production of Hydrocarbons
Authors: Dourado Mailena , Fonseca Noyala , Fréty Roger , Sales Emerson
Published: March 2022

This work aimed to compare two different catalysts in the production of a long chain ketone, intermediate in the production of hydrocarbons, during pyrolysis of tetradecanoic acid as a model fatty acid. The studied variables were the temperature, 450 and 600 ºC, and catalysts, γ-Al2O3 and Nb2O5, the latter has never been studied under such conditions. Pyrolysis experiments were performed in a micro-pyrolyzer coupled to a gas chromatograph with mass spectrometry detector (GC-MS). In all pyrolysis conditions, 14-heptacosanone was formed in varied amounts. Under the best conditions, for pyrolysis at 600 ºC, using γ-Al2O3 as catalyst, the yield of 14-heptacosanone was 18% and the yield of hydrocarbons 24%. The major hydrocarbon product obtained was 1-dodecene. Among the partially deoxygenated compounds, the main products were the ketones 14-heptacosanone and 2-pentadecanone. The present experimental work confirmed also the possibility to obtain hydrocarbons having a chain length longer than the chain length of the original fatty acid reagent, due to a ketonization route followed by decarbonylation.
“Omolu quer todo mundo no Olubaje”
Authors: Guimarães Mota Emília
Published: March 2022

O texto reúne material do trabalho de campo realizado para pesquisa de mestrado apresentada em 2019 com reflexões e observações a partir das experiências vividas durante o ano de 2020, em meio à pandemia de covid-19. A partir da expressão “ser com o outro” utilizada pela Iyalorixá da Casa de Oya, que permite conhecer o modo relacional das religiões de matriz africana (RMAs), o objetivo é apresentar como os desdobramentos da pandemia impactaram o cotidiano do terreiro. Enquanto filha desse terreiro de candomblé goiano e pesquisadora, proponho reflexões sobre as especificidades das RMAs bem como sobre algumas adaptações realizadas na rotina do terreiro, sobre o pedido de Omolu, para todos comparecerem ao Olubajé. Como continuar “sendo com os outros” se as orientações sanitárias impedem contato e proximidade, justamente características das práticas de convivência e ritualísticas dos terreiros?
LA FAMILIA EXTENDIDA EN CHILE:UN RECONOCIMIENTO DEL ROL DE LOS ABUELOS EN BENEFICIO DEL INTERÉS SUPERIOR DEL NIÑO
Authors:   Universidad Santo Tomás, Facultad de Derecho, Iquique, Chile, Astudillo Meza Constanza , Astudillo González Camila ,   Universidad Santo Tomás, Facultad de Derecho, Iquique, Chile
Published: March 2022

La constitución de la familia ha variado considerablemente en las últimas décadas, dando paso a nuevas formas de familia como consecuencia del cambio de roles que sus miembros han experimentado en la sociedad. La concepción matrimonial de la familia, compuesta por un padre, una madre y sus hijos ha sido superada, lo que ha supuesto un desafío para nuestro ordenamiento jurídico, en orden a reconocer esta nueva realidad social. En este contexto y desde el área jurídica, surge la noción de familia extensa con una intensa participación de los abuelos en el rol de crianza, cuyo contenido pretendemos estudiar en esta investigación. De este modo, el trabajo abordará la noción de familia e instituciones que realizan un reconocimiento jurídico a los abuelos.
ANÁLISIS CRÍTICO DE LA NORMATIVA Y JURISPRUDENCIA NACIONAL RESPECTO A LA CONSULTA ÍNDIGENA EN MATERIA AMBIENTAL, EN RELACIÓN CON EL CONVENIO N°169 DE LA ORGANIZACIÓN INTERNACIONAL DEL TRABAJO
Authors:   Tercer Tribunal Ambiental de Valdivia, Chile, Mahn Mendiburo Nicolas
Published: March 2022

El presente trabajo tiene por finalidad realizar un análisis sistemático y crítico de la normativa nacional respecto a la consulta indígena aplicable en materia ambiental, en relación con las disposiciones establecidas en el Convenio N°169 de la Organización Internacional del Trabajo; además, se analizará la forma en que los Tribunales de Justicia han aplicado e interpretado la normativa aludida. Lo anterior, tiene por objeto dar cuenta que la normativa interna no se condice con el estándar aplicable en el Derecho Internacional, sumado a que la jurisprudencia nacional –postura mayoritaria- ha adoptado una interpretación restrictiva al aplicar las disposiciones del Convenio referido.
OMENTARIO DE SENTENCIA. CULPA DE LA VÍCTIMA Y CONCIENCIA DE RIESGOS. COMENTARIO A LA SENTENCIA DE LA CORTE SUPREMA DE 27 DE AGOSTO DE 2019
Authors:   Universidad del Desarrollo, Concepción, Chile, Munita Marambio Renzo
Published: March 2022

El presente comentario se refiere las condiciones necesarias para configurar la culpa de la víctima. En particular, nos detenemos en la necesidad de que la víctima sea consciente de los riesgos que implica la actividad, criterio con el que razona tanto la sentencia citada, como otros fallos.
Knowledge of Children’s Caregivers Regarding Malaria within Vhembe District of Limpopo Province: A Cross-Sectional Study
Authors: Makhado Thendo G. , Tshiovhe Shonisani , Mabadzhe Rudzani , Tshivhase Mashudu , Ramakuela Nditsheni J. , Makhado Lufuno , Maputle Maria S.
Published: March 2022

Background:

The high rate of malaria in the province has negatively impacted the department financially since medicines for malaria treatment are scarce and expensive. Many of the families live near the streams, and they are uninformed about malaria’s clinical manifestations and preventive measures.

Aims:

This study aimed to assess caregivers’ knowledge about malaria in children of selected villages within the Limpopo province of South Africa.

Methods:

Using a cross-sectional study design, this study was conducted in villages surrounding the Vhembe district of Limpopo province. A structured self-administered questionnaire was used to collect data. The data were analysed using descriptive statistics. This study included 80 caregivers of children under 12 years of age.

Results:

It was found that approximately 85% of caregivers knew about malaria’s clinical manifestations and prevention measures.

Conclusion:

Community health care workers can improve the knowledge of caregivers by strengthening health education and preventive campaigns.
Geosocial Networking Smartphone App Use and High-Risk Sexual Behaviors Among Men Who Have Sex With Men Attending University in China: Cross-sectional Study (Preprint)
Authors: Fan Song , Li Peiyang , Hu Yuqing , Gong Hui , Yu Maohe , Ding Yi , Luo Zhenzhou , Wu Guohui , Ouyang Lin , Zou Huachun
Published: March 2022

BACKGROUND

Gay apps are smartphone-based geosocial networking apps where many men who have sex with men (MSM) socialize and seek sex partners. Existing studies showed that gay app use is associated with greater odds of high-risk sexual behaviors and potentially more HIV infections. However, little is known about this behavior among young MSM.

OBJECTIVE

We conducted this study to understand gay app use and its influencing factors among MSM attending university in China.

METHODS

From January to March 2019, participants were recruited from 4 regions with large populations of college students in China: Chongqing, Guangdong, Shandong, and Tianjin. The eligibility criteria were MSM aged 16 years or older, self-identified as a university student, and being HIV negative. A self-administered online structured questionnaire was used to collect data on sociodemographic information, sexual behaviors, gay app use, substance use, and HIV testing history. We performed multivariable log-binomial regression to assess correlates of seeking sex partners via gay apps.

RESULTS

A total of 447 MSM attending university with an average age of 20.4 (SD 1.5) years were recruited. Almost all participants (439/447, 98.2%) reported gay app use at some point in their life, and 240/439 (53.7%) reported ever seeking sex partners via gay apps. Blued (428/439, 97.5%) was the most popular gay app. Higher proportions of sexual risk behaviors (including seeking sex partners via apps [P<.001], engaging in group sex [P<.001], having multiple sex partners [P<.001], unawareness of sex partners’ HIV status [P<.001], and using recreational drugs during sex [P<.02]) were positively associated with the increase in the frequency of gay app use. In multivariable analysis, participants who used gay apps to seek sex partners might be more likely to have multiple sex partners in the past 3 months (adjusted prevalence ratio [APR] 1.53, 95% CI 1.33-1.76; P<.001), engage in group sex in the past 3 months (APR 1.55, 95% CI 1.35-1.78; P<.001), and have sex partners with unknown or positive HIV status (APR 1.72, 95% CI 1.46-2.01; P<.001).

CONCLUSIONS

Seeking sex partners via gay apps may associate with the increased high-risk sexual behaviors among MSM attending university. The causality between seeking sex partners via gay apps and increased high-risk sexual behaviors should be further investigated so as to inform potential policies for HIV prevention.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR1900020645; http://www.chictr.org.cn/showprojen.aspx?proj=34741