bluuebunny/crossref_metadata_2025 huggingface dataset:
Transnational Solidarity Within the EU: Public Support for Risk-Sharing and Redistribution
Authors: Reinl Ann-Kathrin
Published: May 2022

This paper aims to discover underlying, as yet theoretically and empirically unexplored, distinctions in citizens’ views of transnational solidarity within the European Union (EU). Building on literature regarding national welfare states, the paper presents an original concept of transnational solidarity consisting of two latent, not directly measurable, dimensions: first, citizens’ preferences for risk-sharing among EU states and, second, their preferences for intra-EU redistribution. The diverse types of transnational solidarity examined in previous research should be assignable to either one or the other dimension. Moreover, previous research is based on the idea that the concept of transnational solidarity is comparable across EU countries; however, this premise has not been empirically examined so far. To test both these assumptions, I analyze data collected in Austria, Germany, and Greece in 2019 or 2020. The study runs multi-group confirmatory factor analysis to test whether the presented concept of transnational solidarity (a) applies and (b) is comparable between these nations. The empirical analysis supports both these assumptions. The populations of the three countries share the same understanding of transnational solidarity even though the willingness to express cross-country risk-sharing and redistribution varies significantly between the states. The study contributes to current research in the fields of European integration, political sociology, and survey methodology.
Does illusionism imply skepticism of animal consciousness?
Authors: Dung Leonard
Published: May 2022

Illusionism about consciousness entails that phenomenal consciousness doesn’t exist. The distribution question concerns the distribution of consciousness in the animal kingdom. Skepticism of animal consciousness is the view that few or no kinds of animals possess consciousness. Thus, illusionism seems to imply a skeptical view on the distribution question. However, I argue that illusionism and skepticism of animal consciousness are actually orthogonal to each other. If illusionism is true, then phenomenal consciousness does not ground intrinsic value so that the non-existence of phenomenal consciousness would not have ethical implications. In this case, the adequate reaction is to reformulate the distribution question in terms of the quasi-phenomenal functional features associated with the illusion of phenomenal consciousness which do ground intrinsic value. Hence, either illusionism is false or the distribution question does not concern phenomenal consciousness. In any case, illusionism does not directly tell us anything about the distribution question. However, since illusionism forces us to revise our traditional conception of consciousness, it indirectly affects research on animal consciousness by questioning that consciousness is a unified and an all-or-nothing property.
Plant crude extracts containing oligomeric hemagglutinins protect chickens against highly Pathogenic Avian Influenza Virus after one dose of immunization
Authors: Phan Hoang Trong , Tran Hanh Xuan , Ho Thuong Thi , Pham Van Thi , Trinh Vy Thai , Nguyen Tra Thi , Pham Ngoc Bich , Chu Ha Hoang , Conrad Udo
Published: May 2022

Highly pathogenic avian influenza viruses (HPAIV) have been responsible for causing several severe outbreaks across the world. To protect poultry farms and to prevent the possible spread of new influenza pandemics, vaccines that are both efficacious and low-cost are in high demand. We produced stable, large hemagglutinin H5 oligomers in planta by the specific interaction between S•Tag and S•Protein. H5 oligomers combined via S•Tag::S•Protein interaction in plant crude extracts induced strong humoral immune responses, strong neutralizing antibody responses, and resistance in chickens after challenge with a wild type HPAIV H5 virus strain. In all three parameters, plant crude extracts with H5 oligomers induced better responses than crude extracts containing trimers. The neutralizing antibodies induced by by two-dose and one dose immunization with an adjuvanted crude extract containing H5 oligomer protected vaccinated chickens from two lethal H5N1 virus strains with the efficiency of 92% and 100%, respectively. Following housing vaccinated chickens together with ten non-immunized chickens, only one of these chickens had detectable levels of the H5N1 virus. To facilitate the easy storage of a candidate vaccine, the H5 oligomer crude extracts were mixed with adjuvants and stored for 3.5 and 5.5 months at 4 °C, and chickens were immunized with these crude extracts. All these vaccinated chickens survived after a lethal H5N1 virus challenge. H5 oligomer crude extracts are comparable to commercial vaccines as they also induce strong virus-neutralizing immune responses following the administration of a single dose. The cost-effective production of plant crude extract vaccine candidates and the high stability after long-term storage will enable and encourage the further exploration of this technology for veterinary vaccine development.
Biogenesis of spiroketals by submerged cultured basidiomycete Trametes hirsuta
Authors: Grosse Miriam , Heuser Verena , Ersoy Franziska , Berger Ralf G. , Krings Ulrich
Published: May 2022

Volatile spiroketals are well-documented semiochemicals secreted by beetles and wasps for the intra- and interspecies communication. Its use in insect traps and as natural herbicide makes them of commercial interest. Besides insects, fungi are well-known producers, but the fungal biogenesis of spiroketals has remained speculative. Product formation along fatty acid degradation based on non-labeled feeding experiments was assumed. Thus, the observed occurrence of conophthorin and (E)- and (Z)-chalcograns in submerged cultures of the basidiomycete Trametes hirsuta prompted a precursor study aiming at a more detailed insight into their formation. Supplementation of (9Z,12 Z)-octadecadienoic (linoleic) acid resulted in elevated product yields and the identification of a fourth spiroketal, 2,8-dimethyl-1,7-dioxaspiro[5.5]-undecane. However, no intermediates of fatty acid degradation suitable as spiroketal precursors were identified. In addition, the hyphae lacked lipoxygenase activity, which was formerly supposed to be mandatory for spiroketal formation. Supplementation of 1-/2-13C acetate showed incorporation of the label into chalcogran. Therefore, a formation along the polyketide pathway analogous to insects was concluded.

Graphical abstract
Study on the variation in and selection of Fraxinus mandshurica provenances and families in northeast China
Authors: Hao Junfei , Chen Na , Yan Pingyu , Xu Kaiyuan , Zhang Lei , Zhang Hanguo
Published: May 2022

Fraxinus mandshurica Rupr. is one of the main afforestation species in northeast China, and there is great demand for improved F. mandshurica varieties. The results of an investigation into and analysis of the growth traits of F. mandshurica provenances and families showed that there were significant differences in different periods. However, variations in growth traits decreased year by year. There was a significant negative correlation between tree heights of the provenances and sunshine hours in their areas of origin. The provenances of Xinglong, Hailin and Wuchang were selected based on the volume of 18-year-old trees. The average genetic gain from the selection of fast-growing provenances was 19.4%. Ten superior fast-growing families were selected. The average volume of the selected families was 22.6%, higher than that of all families. The correlation coefficient between heights at 6-year-old and at 18a was 0.838 for provenances, and between heights at 4-year-old and at 18-year-old was 0.303 for families. These results indicate that early selection for height in provenances or families could be performed at 6 years or 4 years, respectively. Early selection for DBH and volume in families could start at 8 years.
Immunological Insights into Opioid-Free Anaesthesia in Oncological Surgery: A Scoping Review
Authors: Smith Laura , Cata Juan P. , Forget Patrice
Published: May 2022

Purpose of Review

The influence of opioids on outcomes after cancer surgery when used, or avoided, intraoperatively remains unclear. There is a need to conduct a scoping review to explore the wider context and provide direction for future research. The review will examine the current state of evidence in humans, with a focus on immunological biomarkers and clinically relevant cancer outcomes in trials comparing opioid-free to opioid-based general anaesthesia.

Recent Findings

There is limited research on this subject area, which is mainly focused on breast cancer. The most frequently evaluated immunological parameter is the neutrophil-to-lymphocyte ratio. Cancer outcomes are mainly focused on recurrence.

The central knowledge gap is understanding how the cellular effects of opioids translate into longer-term patient outcomes. The major challenge for future research is accounting for the immunomodulatory effects of a wide range of confounding factors, which have yet to be clarified.
Oncology During the COVID-19 Pandemic: a Lockdown Perspective
Authors: Boniface Danielle , Tapia-Rico Gonzalo
Published: May 2022

Purpose for Review

This perspective piece aims to understand the impacts of the COVID-19 pandemic on the field of oncology, exploring the factors provoking a fall in cancer diagnostic rates, interruption of cancer screening programmes, disruption of oncological treatment and adjuvant care, and the necessary adaption oncological practice has undergone (and will be required to undergo) post-pandemic, including the shift to digital consultations.

Recent Findings

During the COVID-19 pandemic, the field of oncological research has faced significant challenges. Yet, innovation has prevailed with new developments being made across the globe. Looking to the future of oncology, this piece will also suggest potential solutions to overcome the late-stage ramifications of the COVID-19 pandemic.

The COVID-19 pandemic has triggered a global health crisis, the ramifications of which have reached every corner of the world and overwhelmed already overburdened healthcare systems. However, we are still yet to see the full domino effect of the pandemic as it continues to reveal and exacerbate pre-existing weaknesses in healthcare systems across the world.
Multidimensional Profiles of Addictive Smartphone Use: A Latent Profile Analysis
Authors: Yang Hwajin , Tng Germaine Y. Q. , Khoo Shuna S. , Yang Sujin
Published: May 2022

Given that crucial psychological attributes of smartphone addiction have been studied in isolation from each other, we examined latent profiles of emotional distress (depression, stress, loneliness, and fear of missing out; i.e., FoMO); protective traits (self-control, mindfulness, grit); the behavioral inhibition system (BIS) and approach system (BAS; drive, reward responsiveness, and fun seeking) in relation to addictive smartphone use. We identified three distinctive profiles, using five fit statistics: AIC, BIC, adjusted BIC, an entropy, and LRT. The self-controlled, gritty, and mindful profile (22.7%) was characterized by heightened levels of self-control, grit, and mindfulness but lower levels of emotional distress, BIS, and BAS. The emotionally distressed profile (29.8%) was distinguished by elevated levels of depression, stress, loneliness, FoMO, and BIS, but relatively lower protective traits and BAS. Lastly, the approach sensitive profile (47.5%) corresponded to the normative group characterized by relatively higher BAS but mostly average levels of emotional distress and protective traits. When both global and pairwise comparisons between profiles were performed using Wald tests, we found that the self-controlled, gritty, and mindful profile was associated with significantly lower smartphone addiction tendencies than emotionally distressed or approach sensitive profiles, while the latter two did not differ from each other. These results still held when multiple covariates (age, sex, and income) were controlled for. Using a sophisticated person-centered approach, our findings underscore multidimensional psychological profiles that have different associations with smartphone addiction.
Should suicidal ideation be regarded as a dimension, a unipolar trait or a mixture? A model-based analysis at the score level
Authors: Morales-Vives Fabia , Ferrando Pere J. , Dueñas Jorge-M.
Published: May 2022

Screening questionnaires administered in community samples may allow to early identify suicidal ideation (S.I.). Although the results found in these samples suggest that S.I. behaves like a unipolar trait or a quasi-trait, it is routinely assessed using procedures developed for bipolar traits. Therefore, the main aim of this study is to determine whether there is a basis for modelling S.I. as a bipolar trait, a unipolar trait, or a quasi-trait with two classes of individuals (symptomatic and asymptomatic). In a community sample and mainly at the scoring level, we compare the results provided by fitting three models based on different assumptions: GRM (bipolar traits), LL-GRM (unipolar traits) and FMA (quasi-traits). 773 Spanish participants answered a S.I. and a life satisfaction questionnaires. GRM and LL-GRM provided equivalent results at the structural level, but not at the scoring level, especially in the conditional and marginal accuracy of the estimated scores. While the GRM scores are highly accurate only in a narrow range well above the mean, the LL-GRM scores are highly accurate in a much wider range around the mean. They also have different implications for the prediction of life satisfaction. FMA results suggest that an asymptomatic and a symptomatic class could not be clearly differentiated. In conclusion, LL-GRM would make it possible to accurately measure a larger number of subjects in a community sample than GRM, leaving fewer cases of vulnerable people unidentified. These results should be considered by researchers and professionals when deciding which modellings to use for screening purposes.
Can Coastal Habitats Rise to the Challenge? Resilience of Estuarine Habitats, Carbon Accumulation, and Economic Value to Sea-Level Rise in a Puget Sound Estuary
Authors: Moritsch Monica M. , Byrd Kristin B. , Davis Melanie , Good Anthony , Drexler Judith Z. , Morris James T. , Woo Isa , Windham-Myers Lisamarie , Grossman Eric , Nakai Glynnis , Poppe Katrina L. , Rybczyk John M.
Published: May 2022

Sea-level rise (SLR) and obstructions to sediment delivery pose challenges to the persistence of estuarine habitats and the ecosystem services they provide. Restoration actions and sediment management strategies may help mitigate such challenges by encouraging the vertical accretion of sediment in and horizontal migration of tidal forests and marshes. We used a process-based soil accretion model (Coastal Wetland Equilibrium Model) combined with a habitat classification model (MOSAICS) to estimate the effects of SLR, suspended sediment, and inland habitat migration on estuarine habitats, soil carbon accumulation, and economic value of climate change mitigation of carbon accumulation (social cost of carbon dioxide) in a macrotidal estuary in the northwest USA over 100 years (2011 to 2110). Under present-day sediment levels, we projected that after 100 years, most high salt marsh would remain with < 100 cm SLR, but substantial area converted to transitional (low) salt marsh and mudflat with ≥ 100 cm SLR. Increasing sediment availability increased the projected resilience of transitional salt marsh to SLR but did not prevent declines in high marsh area. Projected total carbon accumulation plateaued or declined with ≥ 100 cm SLR, yet the economic value of carbon accumulation continued to rise over time, suggesting that the value of this ecosystem service was resilient to SLR. Doubling or tripling sediment availability increased projected carbon accumulation up to 7.69 and 14.2 kg m−2 and increased total economic value up to $373,000 and $710,000, respectively. Allowing marsh migration supported conversion of upland to freshwater marsh, with slight increases in carbon accumulation. These results inform climate adaptation planning for wetland managers seeking to understand the resilience of estuarine habitats and ecosystem services to SLR under multiple management strategies.
An analytical model for designing defect-free sheet metal profiles with height-variable cross sections manufactured by Flexible Roller Beading
Authors: Wang Tianbo , Groche Peter
Published: May 2022

Following the industrial change from mass production towards serial customization flexible technologies are becoming increasingly important. Therefore, the novel forming process “flexible roller beading” (FRB) is developed, which enables the continuous production of sheet metal profiles with customizable variable cross-sectional height and exploits the lightweight potential of profile-based constructions. To guarantee the quality and further processability of the profiles, component defects—primarily sheet wrinkling in the profile flange—must be avoided. The occurrence of wrinkling is affected by various geometric parameters of the targeted profile. This makes an empirical determination of the material-dependent process limits inefficient due to the expensive computational times of numerical simulations and effort of experimental test executions. Therefore, a mathematical model is developed which allows the analytical prediction of the process instabilities causing sheet wrinkling. The presented paper includes the description of the mechanical characteristics of FRB based on numerical and experimental investigations. The predictive analytical model derived from these findings determines the maximum longitudinal compressive stress in the profile flange, which is responsible for the wrinkling formation, based on the relevant geometric characteristics. By the comparison of the calculated occurring longitudinal compressive stress with the material-specific critical stress, sheet wrinkling can be predicted and failure-free profile geometries can be efficiently designed. The generality of the analytical model, independent of the profile geometry, is validated by experimental tests.
Squeezing mind out of metal: combining textual evidence with scientific data for metallurgy in early dynastic China
Authors: Liu Ruiliang , Pollard A. Mark
Published: May 2022

Since one of the aims of modern archaeometallurgy is to understand the processes carried out by ancient metalworkers, then ideally, we need to go beyond the traditional sources of evidence for such processes — physical investigation and chemical analysis of the objects themselves, and associated manufacturing debris. In order to understand theintentionalitybehind the decisions taken by these metalworkers (the ‘why’, in addition to the ‘how’), then we need to ‘see the world’ as the metalworkers themselves did. The key issue is how to traverse the gulf between ancient and modern perceptions of the natural world. Using ancient Chinese bronze metalwork as an example, we argue that many interesting glimpses of this world can be drawn from the contemporary and later literary sources. But it is crucial to note that these insights have to be supported by independent evidence, such as scientific data or archaeological information. Once verified, these findings can significantly improve our knowledge of the metaphysical perception of metal in the past and offer a heuristic and powerful tool to interpret the relationship between metallurgy and society. For the Chinese Bronze Age, metallurgy performed a crucial part in the political and ritual world. In particular, the different colours of metal objects provide important indicators of the social hierarchy as evidenced by burial practice.
Analysis of a priority queueing system with the enhanced fairness of servers scheduling
Authors: Lee Seokjun , Dudin Alexander , Dudina Olga , Kim Chesoong
Published: May 2022

A multi-server queueing system with two types of customers is analyzed. Both types of customers have own reserved servers and also there is a pool of servers that can be used by both types of customers. Type 1 customers have almost preemptive priority with flexible use of a priority depending on the current number of customers of this type in an infinite buffer. Type 2 customers do not have an input buffer and are lost in cases of absence of available servers upon arrival or expelling (forced termination) from service by Type 1 customers. A multi-dimensional Markov chain, which defines the dynamics of the considered system under the fixed total number of servers, numbers of reserved servers, a pattern of the correlated arriving processes, service rates, and the thresholds defining the mechanism of expelling Type 2 customers from service, is analyzed. A numerical example of solving an optimization problem based on the obtained results is considered. Results can be used for the elaboration of enhanced protocols of servers scheduling in many real-world systems including cognitive radio networks with channels leasing.
Oral Squamous Cell Carcinomas Developing from Oral Lichen Planus: A 5–21 year Retrospective Study
Authors: Sagheb Kawe , Blatt Sebastian , Rahimi-Nedjat Roman-Kia , Lingawi Abdullatif , Schiegnitz Eik , Kumar Vinay V. , Walter Christian , Sagheb Keyvan
Published: May 2022

Background and Aims

There is insufficient data regarding clinical characteristics, relapse rates, as well as lymph node metastasis of squamous cell carcinomas of the oral cavity (OSCC) developing from oral lichen planus (OLP-OSCC). The aim of this retrospective study was to evaluate clinical characteristics, as well as relapse, recurrence and survival rates of OLP-OSCC.

Methods

In a retrospective monocenter analysis, all consecutive patients with an OSCC treated in the time period 1st January 2000–December 31 2016 were reviewed. All patients with OSCC developing from OLP/OLL (oral lichenoid lesions) were identified and analyzed for epidemiological data, risk profile, location of primary tumor, pTNM classification, lymph node metastasis, primary therapy, recurrence, and outcome.

Results

A total of 103 patients (45%♂/ 55%♀) with an average age of 62 ± 14 year were included in this study. At the time of initial diagnosis, 17% (n = 18) of patients had cervical metastases (CM) whereas only 11% (11 patients) displayed advanced tumor sizes (T > 2). T-status (p = 0.003) and histopathological grading (p = 0.001) had an impact on the incidence of CM. 39.6% of the patients developed a relapse after an average of 24 months with a mean of two recurrences per patient. Advanced tumor size had a significant impact on the 5 year overall survival and was associated with disease-free survival of the patients (p < 0.001, respectively p = 0.004).

Conclusion

Although initial lymph node metastases were not more frequent, more aggressive recurrence patterns compared to OSCC were seen for OLP-OSCC. Therefore, based on the study results, a modified recall for these patients is suggested.
Newly identified breast luminal progenitor and gestational stem cell populations likely give rise to HER2-overexpressing and basal-like breast cancers
Authors: McMullen James R. W. , Soto Ubaldo
Published: May 2022

Breast Cancer (BrC) is a common malignancy with genetically diverse subtypes. There is evidence that specific BrC subtypes originate from particular normal mammary cell populations. However, the cell populations that give rise to most BrC subtypes are unidentified. Several human breast scRNAseq datasets are available. In this research, we utilized a robust human scRNAseq dataset to identify population-specific marker genes and then identified the expression of these marker genes in specific BrC subtypes. In humans, several BrC subtypes, HER2-enriched, basal-like, and triple-negative (TN), are more common in women who have had children. This observation suggests that cell populations that originate during pregnancy give rise to these BrCs. The current human datasets have few normal parous samples, so we supplemented this research with mouse datasets, which contain mammary cells from various developmental stages. This research identified two novel normal breast cell populations that may be the origin of the basal-like and HER2-overexpressing subtypes, respectively. A stem cell-like population, SC, that expresses gestation-specific genes has similar gene expression patterns to basal-like BrCs. A novel luminal progenitor cell population and HER2-overexpressing BrCs are marked by S100A7, S100A8, and S100A9 expression. We bolstered our findings by examining SC gene expression in TN BrC scRNAseq datasets and S100A7-A9 gene expression in BrC cell lines. We discovered that several potential cancer stem cell populations highly express most of the SC genes in TN BrCs and confirmed S100A8 and A9 overexpression in a HER2-overexpressing BrC cell line. In summary, normal SC and the novel luminal progenitor cell population likely give rise to basal-like and HER2-overexpressing BrCs, respectively. Characterizing these normal cell populations may facilitate a better understanding of specific BrCs subtypes.
Relationship Between Sexual Behaviors with Non-committed Relationship Partners and COVID-19 Restrictions and Notification Rates: Results from a Longitudinal Study of Gay and Bisexual Men in Australia
Authors: Storer Daniel , Prestage Garrett , McManus Hamish , Maher Lisa , Bavinton Benjamin R. , Ellard Jeanne , Jin Fengyi , Philpot Steven , Holt Martin , Saxton Peter , Haire Bridget , Murphy Dean , Hammoud Mohamed A.
Published: May 2022

Introduction

COVID-19 related lockdowns have impacted the sexual activity of gay and bisexual men (GBM). We investigated trends in sexual behaviors and the COVID-19 context in which they occurred (COVID-notification rates and jurisdictional restrictions) to understand changes in the duration and severity of periods of lockdown on the sexual behavior of Australian GBM.

Methods

In an online, prospective observational study of 831 GBM from May 2020 to May 2021, we investigated associations between changes in sexual behavior among Australian GBM, lockdowns, and COVID-19 notification rates through weekly surveys from May 2020 to May 2021.

Results

The mean age was 45.71 years (SD: 13.93). Most identified as gay (89.0%) and 10.2% were living with HIV. There was an overall increase in the mean weekly number of non-committed relationship partners (0.53–0.90, p < 0.001). The state of Victoria experienced a significant extended COVID-19 outbreak, accompanied by severe lockdown restrictions. In response, Victorian men’s partner numbers shifted three times, while elsewhere there was an overall gradually increasing trend.

Conclusions

Less severe outbreaks with shorter lockdown periods, involving fewer and geographically contained, COVID-19 notifications were accompanied by non-significant changes in sex with non-relationship partners than more severe outbreaks over extended periods and larger geographical areas.
Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke
Authors: Ye Baoye , Wei Dingqun , Pan Lin
Published: May 2022

Objective

The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined.

Methods

Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Traditional Medical University (Fujian, China) from January 2017 to March 2020. Cognitive impairment was assessed using the MoCA, and potential correlations were explored between clinicodemographic characteristics (sex, age, stroke location and etiology) and MoCA dimensions or total MoCA score.

Results

Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and visuospatial orientation. However, multivariate linear regression identified only executive function, naming, attention, memory ability, and visuospatial orientation as significantly associated with the total MoCA score.

Conclusions

We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, naming, attention, memory ability, and visuospatial orientation.
Cytomegalovirus infection and rehospitalization rates after allogeneic hematopoietic stem cell and solid organ transplantation: a retrospective cohort study using German claims data
Authors: Teschner Daniel , Knop Jana , Piehl Christian , Junker Sophia , Witzke Oliver
Published: May 2022

Purpose

This study aimed to describe the cytomegalovirus (CMV) infection rate, rehospitalizations, and comorbidities following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and solid organ transplantation (SOT).

Methods

Patients who received allo-HSCT or SOT in 01/07/2015–30/06/2018 were identified using anonymized German claims data. The transplantation-related hospital admission date was defined as the index date, and patients were followed for up to 12 months (or death, first event relevant). The frequency of CMV infections (confirmed outpatient/inpatient diagnoses, ICD-10-GM codes: B25.-/B27.1) and the rate, number, and duration of all-cause rehospitalizations in the follow-up period were evaluated.

Results

A total of 226 allo-HSCT and 250 SOT patients were identified (mean age 52.8 years, 38.9% female). During the 12 months after transplantation, 29.2% of allo-HSCT patients and 16.8% of SOT patients received a CMV diagnosis. The majority of these diagnoses were given during the initial hospitalization or within the following 3 months. Across transplantation types, CMV patients had more hospital readmission days per patient-year (allo-HSCT 93.3 vs. 49.4, p = 0.001; SOT 42.0 vs. 20.7, p = 0.005), with a longer mean duration of readmissions (allo-HSCT 22.4 vs. 15.4 days, p < 0.001; SOT 11.6 vs. 7.5 days, p = 0.003). Comorbidity burden in transplantation patients was substantial, with several diagnoses being significantly more common among patients with CMV vs. non-CMV. One-year mortality did not differ significantly between patients with/without CMV.

Conclusion

Burden of transplant recipients with CMV in terms of rehospitalizations and comorbidities is substantial, highlighting the need for improved CMV prevention and treatment.
The Association Between Mental Well-Being and School Attendance Among Palestinian Adolescent Refugees in UNRWA Schools
Authors: Nathani Komal , Lee Wei-Chen , Taha Shaden , Horino Masako , Seita Akihiro , Serag Hani
Published: May 2022

Adolescent refugees experience psychosocial stressors, including traumatic events, poverty, and loss of home and family. Exposure to conflict affects mental well-being in Palestinian adolescent refugees. Adolescent girls are among those vulnerable to post-traumatic stress associated with living in conflict zones, We assessed the association between reported mental well-being and school attendance among Palestinian adolescent refugees in UNRWA schools in Occupied Palestinian Territories, Jordan, Lebanon, and Syria. We also examined differences based on gender and place of residence, Palestinian adolescent refugees with certain mental well-being concerns were more likely to miss more days of school. Generally, females reported higher rates of loneliness and worry, but males were more likely to miss school. Gender-based differences were highest in Lebanon and least in the West Bank, More school-based and community-based mental well-being interventions are needed. Female-tailored programs are needed, especially in Palestinian refugee camps in Lebanon.
A novel ensemble feature selection method for pixel-level segmentation of HER2 overexpression
Authors: Aguilera Ana , Pezoa Raquel , Rodríguez-Delherbe Andrea
Published: May 2022

Classifying histopathology images on a pixel-level requires sets of features able to capture the complex characteristics of the images, like the irregular cell morphology and the color heterogeneity on the tissue aspect. In this context, feature selection becomes a crucial step in the classification process such that it reduces model complexity and computational costs, avoids overfitting, and thereby it improves the model performance. In this study, we propose a new ensemble feature selection method by combining a set of base selectors, classifiers, and rank aggregation methods, aiming to determine from any initial set of handcrafted features, a smaller set of relevant color and texture pixel-level features, subsequently used for segmenting HER2 overexpression on a pixel-level, in breast cancer tissue images. We have been able to significantly reduce the set of initial features, using the proposed ensemble feature selection method. The best results are obtained using $$\chi ^2$$

χ
2

, Random Forest, and Runoff as the based selector, classifier, and aggregation method, respectively. The classification performance of the best model trained on the selected features set results in 0.939 recall, 0.866 specificity, 0.903 accuracy, 0.875 precision, and 0.906 F1-score.
A Multiple and Multidimensional Linguistic Truth-Valued Reasoning Method and its Application in Multimedia Teaching Evaluation
Authors: Lu Yifan , Li Nan , Lin Hongmei , Zheng Hongliang , Li Xiaofeng , Zou Li
Published: May 2022

With the expansion of the epidemic, online multimedia teaching has become a common trend. The reasoning model of multimedia teaching evaluation is a useful tool to infer the result of teaching effects and predict the tendency. However, the ambiguity in the linguistic-valued evaluation leads to reasoning problems always in the context with uncertainty. To make the reasoning model better deal with multiple and multidimensional reasoning problems in uncertainty environment, while considering both positive evidence and negative evidence at the same time, this paper mainly focuses on a linguistic truth-valued intuitionistic fuzzy layered aggregation (LTV-IFLA) reasoning method. First, based on the layered linguistic truth-valued intuitionistic fuzzy lattice (LTV-IFL), we realize aggregating the linguistic truth-valued information through the layered average aggregation (LAA) operator presented by this paper. Furthermore, a layered weighted average aggregation (LWAA) operator is proposed to consider setting different weights to achieve personalization of the reasoning results. Finally, a multiple multidimensional reasoning model which simulates the reasoning of human language is presented to illustrate the method’s rationality and validity.
Determine both the conformation and orientation of a specific residue in α-synuclein(61–95) even in monolayer by 13C isotopic label and p-polarized multiple-angle incidence resolution spectrometry (pMAIRS)
Authors: Wang Chengshan , Zhou Yiqun , Ewuola Christopher , Akinleye Toyin , Hasegawa Takeshi , Leblanc Roger M.
Published: May 2022

Protein’s magic function stems from its structure and various analytical techniques have been developed for it. Among proteins, membrane proteins are encoded 20–30% of genomes, whereas cause challenges for many analytical techniques. For example, lots of membrane proteins cannot form single crystal structure required by X-ray crystallography. As for NMR, the measurements were hindered by the low tumbling rates of membrane (i.e., phospholipid bilayers) where membrane proteins exist. In addition, membrane proteins usually lay parallel to the surface of phospholipid bilayers or form transmembrane structure. No matter parallel or perpendicular to phospholipid bilayers surface, membrane proteins form monolayer structure which is also difficult for X-ray and NMR to provide high-resolution results. Because NMR and X-ray crystallography are the two major analytical techniques to address protein’s structure, membrane proteins only contribute 2.4% to the solved protein databank. Surface FT-IR techniques can evaluate the conformation and orientation of membrane proteins by amide I band. Specifically for α-helical peptides/proteins, the orientation of the axis is critical to decide whether proteins form transmembrane structure. Notice that the traditional FT-IR can only provide “low-resolution” results. Here, 13C isotope was introduced into the nonamyloid component (NAC), which spans residues 61–95 of α-synuclein (α-syn). Then, p-polarized multiple-angle incidence resolution spectrometry (pMAIRS) was used to determine the orientation of a specific residue of α-helical NAC in monolayer. In general, pMAIRS is a novel technique to work complementary with X-ray and NMR to address membrane peptides/proteins structure with high resolution even in monolayer.

Graphical abstract
Machine Learning
Authors: Lindholm Andreas , Wahlström Niklas , Lindsten Fredrik , Schön Thomas B.
Published: May 2022

This book introduces machine learning for readers with some background in basic linear algebra, statistics, probability, and programming. In a coherent statistical framework it covers a selection of supervised machine learning methods, from the most fundamental (k-NN, decision trees, linear and logistic regression) to more advanced methods (deep neural networks, support vector machines, Gaussian processes, random forests and boosting), plus commonly-used unsupervised methods (generative modeling, k-means, PCA, autoencoders and generative adversarial networks). Careful explanations and pseudo-code are presented for all methods. The authors maintain a focus on the fundamentals by drawing connections between methods and discussing general concepts such as loss functions, maximum likelihood, the bias-variance decomposition, ensemble averaging, kernels and the Bayesian approach along with generally useful tools such as regularization, cross validation, evaluation metrics and optimization methods. The final chapters offer practical advice for solving real-world supervised machine learning problems and on ethical aspects of modern machine learning.
Neurovascular Compression in the Anterior Visual Pathway: A Case Series
Authors: Gelkopf Maxwell J. , Jabehdar Maralani Pejman , da Costa Leodante , Birt Catherine , Sundaram Arun N. E.
Published: May 2022

A retrospective review of 29 patients with neurovascular compression syndrome (NVCS) involving the anterior visual pathway was conducted. Various patterns of NVCS and visual defects were identified, most commonly involving the optic nerve and internal carotid artery. Most patients were stable, except one with progressive visual field defects. Although mostly asymptomatic, NVCS can rarely cause compressive optic neuropathy. NVCS should be kept in the differential diagnosis of normal tension glaucoma, especially with progressive visual loss despite treatment. Patients with progressive visual loss may require decompression surgery. Non-contrast computed tomography scan may miss NVCS, and magnetic resonance imaging is diagnostic.
Conceptual Framework for Understanding Incident Management Systems During Public Health Emergencies
Authors: Clark-Ginsberg Aaron , Fisher Holly , Awan Jalal , Rico Adriana , Thomas Tracy , Rose Dale , Vagi Sara , Jenkins Leecresia , Nelson Christopher
Published: May 2022

Objective:

Effective incident management is essential for coordinating efforts of multiple disciplines and stakeholders when responding to emergencies, including public health disasters such as the ongoing coronavirus disease 2019 (COVID-19) pandemic.

Methods:

Existing research frameworks tend to focus on formal structures and doctrine (eg, ICS-NIMS); however, organizational processes that underlie incident management have not been systematically assessed and synthesized into a coherent conceptual framework.

Results:

The lack of a framework has hindered the development of measures of performance that could be used to further develop the evidence base and facilitate process improvement. To address this gap, we present a conceptual framework of incident management drawn from expert feedback and a review of literature on incident management and related fields. The framework features 23 measurement constructs grouped into 5 domains: (1) situational awareness and information sharing, (2) incident action and implementation planning, (3) resource management and mobilization, (4) coordination and collaboration, and (5) feedback and continuous quality improvement.

Conclusions:

As such, the article provides a first step toward the development of robust measures for assessing the performance and effectiveness of incident management systems.
Morphometric analysis of stem-group mollusks from the northern Yangtze Craton, China
Authors: Pang Yanchun , Steiner Michael , Yang Ben , Hou Mingcai , Ogg James G. , Ji Wenhu , Hu Qiang , Liang Siyu , Zhang Mengshao , He Yangjian , Lin Li
Published: May 2022

Cap-shaped skeletal fossils are the earliest undisputed body fossils of mollusks appearing in the basal Cambrian. A study on the morphometry of cap-shaped fossils from the Nanjiang area (North Sichuan, China) is undertaken to understand the origin and evolution of the early mollusks. The distribution of these fossil cap-shaped mollusks indicates a stepwise increase in their diversity during the early Cambrian.MaikhanellaZhegallo in Voronin et al., 1982 co-occuring with the spinose sclerites of siphogonuchitids, is regarded as the earliest scleritized mollusk. It is followed by other maikhanellids, e.g.,PurellaMissarzhevsky, 1974 andYunnanopleuraYu, 1987, which co-occur with the earliest univalved helcionellids, e.g.,IgorellaMissarzhevsky in Rozanov et al., 1969. Cluster analysis of their morphometric characteristics shows that theMaikhanellagroup is similar to thePurellaandYunnanopleuragroups, but is less comparable with univalved helcionellids. The maikhanellids are interpreted as representatives of the stem group Aculifera, although it remains uncertain if one or two larger cap-shaped shell plates were present on the elongate slug-like body, comparable to those ofHalkieriaPoulsen, 1967 orOrthrozanclusConway Morris and Caron, 2007. Maikhanellids are characterized by the prominent protrusions or scales on the cap-shaped shell plates arranged in a concentric pattern around the shell apex. Evolutionarily, the protrusions or scales are reduced in younger strata, whereas subsequently a typically concentric ornament developed, the cap-shaped shell plates developed higher profiles, and the apical region became increasingly bare of scales. Meanwhile, the cap-shaped shell plates gradually evolved into a helcionellid-like appearance with an anteroposteriorly inclined apex. The morphological evolution of the earliest sclerotized mollusks reflects biotic evolution and environmental adaption among the stem-group mollusks during the early Cambrian.
Citellinema (Nematoda: Heligmosomidae) from North America with descriptions of 2 new species from the red squirrel Tamiasciurus hudsonicus and 1 from the Canadian woodchuck, Marmota monax
Authors: Alnaqeb Haitham , Galbreath Kurt E. , Koehler Anson V. , Campbell Mariel L. , Jiménez F. Agustín
Published: May 2022

Citellinema Hall, 1918 includes 6 valid species of gastrointestinal nematodes of sciurids. Two species occur in the Palearctic and 4 in the Nearctic, 3 of which occur minimally across Colorado, Idaho and Oregon and 1, Citellinema bifurcatum, has a wide distribution across North America. Members of the genus are didelphic, possess a cephalic vesicle, a terminal spine-like process in females and feature robust spicules, consisting of a proximal end fused and semicylindrical shaft connected to a lamina supported by 2 terminal filiform processes. Typically, the size of the spicules is used to differentiate species. As part of the Beringian Coevolution Project, specimens provisionally identified as C. bifurcatum were collected through intensive field sampling of mammals and associated parasites from across localities spanning the Holarctic. These specimens revealed considerable genetic variability at both mitochondrial and nuclear loci, supporting the identification of deeply divergent clades. Examination of these new specimens, along with the holotypes of C. bifurcatum and Citellinema quadrivittati indicates that Citellinema monacis (previously synonymized with C. bifurcatum) should be resurrected and 3 additional species described. We suggest that the apparent bifurcated nature of the spicule should be considered a generic diagnostic trait, while the proportional length of the lamina relative to that of the spicule is used as a specific character. We demonstrate the critical need for continued inventory of often poorly known assemblages of hosts and parasites, contributing to a growing baseline of archival specimens, collections and information that make explorations of faunal structure and diversity possible.
Mapping functional tree regions of the Atlantic Forest: how much is left and opportunities for conservation
Authors: Silva José Luiz Alves , Souza Alexandre F , Vitória Angela Pierre
Published: May 2022

Many biomes still lack an overall view of their macro-functional structure (i.e., natural biogeographical regions and zones), including the Atlantic Forest biodiversity hotspot. The effective design of protected areas depends on the spatial identification of units with ecologically distinct content, whether it be floristic, phylogenetic or functional. This study used a regionalization approach to identify the potential functional regions of the Atlantic Forest by interpolating functional data from forest remnants into the entire original occurrence area of the biome, including deforested lands. Conservation status was then estimated. Analysis of seven traits of leaf, wood, seed and plant size revealed that the biome is structured over 14 functional regions and three zones (clusters of regions). Functional regions represented specific combinations of traits rather than being characterized by extremely high or low values of a single trait. They retained an average of 29.5% of forest remnants (range: 7.63–54.66%) and 10.82% of protected areas (range: 0.35–35.78%). By analysing the functional space occupied by all regions, captured by two principal component analysis axes using the pixel-level information contained in interpolated trait maps, we showed that large parts of this space were not covered by forest remnants or protected areas and that the most represented regions had serious deficits in protected areas. Although the Serra do Mar mountain range in the south and south-east Atlantic Forest is relevant as a centre of species endemism and richness and has received considerable attention for carrying out ecological studies and creating protection areas, this range does not fully encompass the functional biodiversity of such a rich biome. Our results demonstrate the potential for combining regionalization and conservation approaches to unravel the macro-structures of biomes.