bluuebunny/crossref_metadata_2025 huggingface dataset:
Preservice Music Teacher Identity Construction Through Metaphor
Authors: Wagoner Cynthia L.
Published: December 2020

I investigated how preservice instrumental music teachers understand and describe their teacher identity through the use of metaphor in a one-semester instrumental methods course emphasizing authentic context learning. Twenty-five third-year instrumental methods course music education students created a personal metaphor to explore their professional identity construction. Preservice teacher metaphors were revisited throughout the semester, while students participated in an authentic context learning experience in an urban instrumental music classroom. Data sources included student artifacts, informal interviews, and observation/field notes. The impact of teaching within an authentic learning context appears to enrich the ways in which preservice teachers are able to articulate details of their metaphor descriptions. Through their reflections across the semester, preservice teachers demonstrated how personal metaphors were used to restructure their understandings of teacher identity and capture some of the complexities of becoming teachers.
Re: Updates in the management and future landscape of urothelial carcinoma
Authors: Sarkis J , Assaf J
Published: December 2020

Immunotherapy is gradually revolutionizing bladder cancer treatment. In this extensive review published by Hanna et al. in your journal, the authors presented recent studies that are trying to challenge the standard platinum-based chemotherapy as first-line treatment of metastatic bladder cancer by chemoimmunotherapy. However, upfront pembrolizumab, atezolizumab and durvalumab association with standard of care chemotherapy did not improve overall survival when compared to chemotherapy alone.

We hereby highlight a study that was not included in this review, the INDUCOMAIN trial, by discussing its results and its future implications on immunotherapy for metastatic bladder cancer.
Community Participation and Quality of Life in Nature-Based Tourism: Exploring The Antecedents and Moderators
Authors: Ali Md Borak , Quaddus Mohammed , Rabbanee Fazlul K. , Shanka Tekle
Published: December 2020

This study offers a conceptual framework reflecting relationships among nature-based antecedents of community participation in an ecotourism destination en route to achieving quality of life of the local community. The study also examines the moderating role of political instability and government policy in ensuring community participation and attaining quality of life, respectivelyData were collected through a structured survey from 449 local community members of Sundarbans, Bangladesh, which were analysed using SmartPLS-based structural equation modeling. Results revealed that community participation depends on natural attraction and motivation of the people to be involved with ecotourism activities. Such participation is found to influence quality of life of the community people. The results show support for significant moderating effects of political instability and government policy on the relationship between (a) ecotourism motivation and community participation and (b) community participation and quality of life, respectively. The findings offer significant theoretical and practical implications.
A systematic review of the brachial vein arteriovenous fistulas as a viable option for haemodialysis access
Authors: Gavriilidis Paschalis , Papalois Vassilios
Published: December 2020

Objectives:

International guidelines recommend the use of autogenous vascular access. Where suitable superficial veins are unavailable deeper veins may be used as an option. In most cases, basilic veins are used when cephalic veins are unavailable; arteriovenous fistulas using the brachial vein from the deep venous network are rare. Therefore, the purpose of the present study was to conduct a systematic review of the available literature evaluating the use of the brachial vein in arteriovenous fistulas.

Methods:

Systematic literature search of electronic databases in accordance with PRISMA was conducted. The primary outcomes of this study were primary and secondary patency rates for brachial vein arteriovenous fistulas; the secondary outcomes were the rates of access thrombosis, steal syndrome, pseudo-aneurysm and infection.

Results:

The 1-year primary, assisted, and secondary patency was recorded at (24%–77%), (45%–85%) and (45%–96%), respectively. The 2-year primary, assisted and secondary patency rate was recorded at (12%–46%), (19%–75%) and (19%–92%), respectively. However, the consistency regarding the reports and definitions used were highly variable. The incidence rate of infection, thrombosis and steal syndrome was 5% (0%–12%), 15.9% (9.5%–35%) and 3% (2%–6%), respectively.

Conclusion:

Available studies support the use of brachial veins as a reliable access option in patients with non-accessible superficial veins where an autologous option is required.
Hybrid angioplasty-catheter placement procedure performed in a hemodialysis patient with central venous obstruction disease. Presentation of a case
Authors: Ptohis Nikolaos , Theodoridis Panagiotis G , Raftopoulos Ioannis
Published: December 2020

Obstruction or occlusion of the central veins (Central venous disease, CVD) represents a major complication in hemodialysis patients (HD) limiting central venous access available for a central venous catheter placement. Endovascular treatment with percutaneous transluminal angioplasty (PTA) is the first therapeutic option to restore patency and gain access. This case presents our initial experience of a HD patient with CVD treated with a combination therapy of a balloon PTA to the left brachiocephalic trunk, through the right hepatic vein and standard catheter placement technique to the previously occluded junction of the left internal jugular vein to the left subclavian vein.
Evaluation of web reinforcements in prestressed concrete box girders through shear-transverse bending domains
Authors: Granata Michele Fabio , Recupero Antonino
Published: December 2020

In concrete box girders, the amount and distribution of reinforcements in the webs have to be estimated considering the local effects due to eccentric external loads and cross-sectional distortion and not only the global effect due to the resultant forces of a longitudinal analysis: shear, torsion and bending. This work presents an analytical model that allows designers to take into account the interaction of all these effects, global and local, for the determination of the reinforcements. The model is based on the theory of stress fields and it has been compared to a 3D finite element analysis, in order to validate the interaction domains. The results show how the proposed analytical model allows an easy and reliable reinforcement evaluation, in agreement with a more refined 3D analysis but with a reduced computational burden.
Methodology for sampling and detection of airborne coronavirus including SARS-CoV-2
Authors: Yun Hyunjun , Yang Jinho , Seo Ji-Hoon , Sohn Jong-Ryeul
Published: December 2020

In recent years, several epidemics by transmissible respiratory viruses have emerged, especially pandemics caused by coronaviruses. The most significant public health emergency may be the COVID-19 pandemic. Identifying the transmission of infectious disease plays an important role in healthcare for protecting and implementing effective measures for public health. However, studies on SARS-CoV-2 transmission dynamics are lacking. Infection with the airborne virus is very important and airborne transmission is likely to cause major problems. However, research on the aerosol route of the virus is very limited. Here, we aimed to present airborne coronavirus detection methods in previous studies and address the importance of methodology for the future. In previous studies on airborne coronavirus, detection methods were different in each study. Therefore, comparison between the airborne virus detected in each study is impossible, and the risk assessment could not be properly analysed due to limitations in applying it as basic data. There is currently a risk assessment for coronavirus, but the risk assessment due to airborne transmission is insufficient. Therefore, recommending accurate guidelines for airborne transmission is difficult. Future research should be conducted to standardize airborne virus detection methods to prevent transmission through rapid risk assessment and monitoring.
Pilonidal disease treatment by radial laser surgery (FiLaC™): The first Finnish experience
Authors: Harju Jukka , Söderlund Filip , Yrjönen Antti , Santos Alexandre , Hermunen Kethe
Published: December 2020

Background and objective:

Pilonidal disease is common, and it afflicts especially young adults, causing disability. Several types of treatment methods are applicable, but no consensus exists regarding the best method. The aim of our study was to assess the novel radial laser probe treatment in pilonidal disease and report the success rate and recurrence rate.

Methods:

We studied retrospectively 86 patients who, according to our hospital patient records, underwent radial laser probe surgery between January 2017 and September 2019.

Results:

In a mean follow-up time of 14 months, the success rate at 2 months was 86%. Most operations were done under local anesthesia on a day-surgery basis. The recovery time was rapid, and median sick leave was 12 days. Of those initially successfully treated, 3% developed a recurrence. Altogether 17% of the patients underwent a re-operation. Spillage of pus during surgery, however, reduced the success rate to 53%.

Conclusions:

Radial laser probe treatment is a quick, safe, and minimally invasive treatment choice for pilonidal disease, especially when no active infection is present.
Secondary traumatic stress and vicarious post-traumatic growth among social workers who have worked with abused children
Authors: Weiss-Dagan Shlomit , Ben-Porat Anant , Itzhaky Haya
Published: December 2020

Working with abused children can have positive and negative implications for social workers. Some of these implications have been conceptualized as secondary traumatic stress and vicarious post-traumatic growth. The current study examined the question of whether these two phenomena share similar contributing factors. Based on the social-ecological theory and previous studies on secondary traumatic stress, we examined the contribution of personal factors and level of exposure to trauma (i.e. years of work experience, professional exposure to child abuse, mastery) and environmental factors (i.e. social support, supervision, and role stress) to the explained variance of secondary traumatic stress and post-traumatic growth, with the goal of understanding these two potential outcomes. This cross-sectional study comprised 255 social workers who worked with abused children.

Findings

The results showed that despite the correlation between the two outcomes—post-traumatic growth and secondary traumatic stress—they shared only one common predictive factor: the extent of social workers’ exposure to abused children. Role stress was correlated positively, and mastery was correlated negatively, with secondary traumatic stress only. Years of work experience was correlated positively with post-traumatic growth only.

Applications

The current study shows the importance of continuing efforts to identify the factors that contribute to post-traumatic growth. At the same time, efforts should be made to foster certain personal and environmental factors to reduce secondary traumatic stress levels.
The participatory arts-based research project as an exceptional sphere of belonging
Authors: Nunn Caitlin
Published: December 2020

While belonging is rarely an explicit concern of participatory arts-based research (PABR), fostering inclusive relations is both an important condition for and outcome of PABR projects. Based on a participatory arts-based study with refugee-background young people in the United Kingdom and Australia, this article proposes five dimensions of PABR that mediate belonging within the project and shape possibilities for belonging beyond it: resources, relations, reflection, representation and recognition. Acknowledging the possibilities for transformative belonging emerging from PABR’s unique combination of participation, arts and research, this article draws on Bourdieu’s framing of the research interview as an ‘exceptional situation for communication’ to conceptualise the PABR project as an exceptional sphere of belonging. Attending to (non)belonging in participatory arts-based research projects facilitates new insights into the practical, affective, embodied, socio-cultural and ethical relations that they produce and makes an important contribution to our understanding of PABR’s much lauded – but less well evidenced – transformative potential.
Real time Energy Efficiency Operational Indicator: Simulation research from the perspective of life cycle assessment
Authors: Sun Chao , Wang Haiyan , Liu Chao , Zhao Ye
Published: December 2020

CO2 emissions during ship building, maintenance, and scrapping are not be involved when defining Energy Efficiency Operational Indicator (EEOI). However, these CO2 emissions can only show its value during operation phase of ship life. In order to evaluate the effect of CO2 emissions during ship building, maintenance, and scrapping on energy efficiency, a real time EEOI definition was put forward, a life cycle assessment (LCA) calculation framework was established, and a ship propulsion model with main diesel engine was built. A bulker carrier YUMING was taken as the case ship. CO2 emissions during ship building, maintenance, and scrapping were calculated. Main engine revolution and real time EEOI value with other parameters were obtained by simulating in different ship draft. The results show that life cycle assessment result will explicitly increase the real time EEOI value especially in lower engine speed and lower ship draft. The engine revolution at the lowest EEOI value will increase explicitly by life cycle assessment result. It means that the lower limit of ship speed should increase during slow steaming. Therefore, slow steaming may bring less environmental benefit if the life cycle assessment result is involved.
Filtration mechanisms and manufacturing methods of face masks: An overview
Authors: Adanur Sabit , Jayswal Ajay
Published: December 2020

Face masks are loose-fitting masks that cover the nose and mouth and have ear ties at the back of the head whereas respirators are tight-fitting face covering devices which filter the air during inhalation and exhalation. Guidelines issued by the US Centers for Disease Control and Prevention (CDC) regarding proper design, filtration process and wearing should be followed. The mask equipment provides protection against the infections caused by particulate matters (PM), especially PM2.5, and biological pathogens such as bacteria and viruses. Although face masks offer benefits to a greater extent, it is not recommended to wear them for a long period of time. As N95 masks closely fit with the face, it may result in negative impact on respiratory and dermal mechanisms of human thermoregulation. In this article, currently available face masks including cloth masks, their filtration mechanisms, manufacturing methods and decontamination methods are reviewed for the purpose of helping with the coronavirus pandemic (COVID-19).
Coaching With Artificial Intelligence: Concepts and Capabilities
Authors: Graßmann Carolin , Schermuly Carsten C.
Published: December 2020

Artificial intelligence (AI) has brought rapid innovations in recent years, transforming both business and society. This paper offers a new perspective on whether, and how, AI can be employed in coaching as a key HRD tool. We provide a definition of the concept of AI coaching and differentiate it from related concepts. We also challenge the assumption that AI coaching is feasible by challenging its capability to lead through a systematic coaching process and to establish a working alliance to clients. Based on these evaluations, AI coaching seems to encounter the greatest difficulties in the clients’ problem identification and in delivering individual feedback, which may limit its effectiveness. However, AI generally appears capable of guiding clients through many steps in the coaching process and establishing working alliances. We offer specific recommendations for HRD professionals and organizations, coaches, and developers of AI coaching programs on how AI coaching can contribute to enhance coaching practice. Combined with its lower costs and wider target group, AI coaching will likely transform the coaching profession and provide a future HRD tool.
The Romano–Wolf multiple-hypothesis correction in Stata
Authors: Clarke Damian , Romano Joseph P. , Wolf Michael
Published: December 2020

When considering multiple-hypothesis tests simultaneously, standard statistical techniques will lead to overrejection of null hypotheses unless the multiplicity of the testing framework is explicitly considered. In this article, we discuss the Romano–Wolf multiple-hypothesis correction and document its implementation in Stata. The Romano–Wolf correction (asymptotically) controls the familywise error rate, that is, the probability of rejecting at least one true null hypothesis among a family of hypotheses under test. This correction is considerably more powerful than earlier multiple-testing procedures, such as the Bonferroni and Holm corrections, given that it takes into account the dependence structure of the test statistics by resampling from the original data. We describe a command, rwolf, that implements this correction and provide several examples based on a wide range of models. We document and discuss the performance gains from using rwolf over other multiple-testing procedures that control the familywise error rate.
Speaking Stata: Loops, again and again
Authors: Cox Nicholas J.
Published: December 2020

Two commands in official Stata, foreach and forvalues, provide structures for looping through lists of values (variable names, numbers, arbitrary text) and repeating commands using members of those lists in turn. These commands may be used interactively, and none is restricted to use in Stata programs. They are explained and compared in some detail with a variety of examples. In addition, a self-contained exposition is given on local macros, understanding of which is needed for use of foreach and forvalues.

This column is a revision of the column “How to face lists with fortitude”, which appeared in Stata Journal 2: 202–222 (2002). (The bizarre bibliographical details are too, too extraordinary not to be flagged but were pure happenstance.) The presentation here has been trimmed of now historic content and corrected, improved, and updated in several minor details.
Development of a Comprehensive Outcome Measure for Motor Coordination; Step 1: Three-Phase Content Validity Process
Authors: Alouche Sandra R. , Molad Roni , Demers Marika , Levin Mindy F.
Published: December 2020

Background

Motor coordination, the ability to produce context-dependent organized movements in spatial and temporal domains, is impaired after neurological injuries. Outcome measures assessing coordination mostly quantify endpoint performance variables (ie, temporal qualities of whole arm movement) but not movement quality (ie, trunk and arm joint displacements).

Objective

To develop an outcome measure to assess coordination of multiple body segments at both endpoint trajectory and movement quality levels, based on observational kinematics, in adults with neurological injuries.

Methods

A 3-phase study was used to develop the Comprehensive Coordination Scale (CCS): instrument development, Delphi process, and focus group meeting. The CCS was constructed from common tests used in clinical practice and research. Rating scales for different behavioral elements were developed to guide analysis. For content validation, 8 experts (ie, neurological clinicians/researchers) answered questionnaires about relevance, comprehension, and feasibility of each test and rating scale. A focus group conducted with 6 of 8 experts obtained consensus on rating scale and instruction wording, and identified gaps. Three additional experts reviewed the revised CCS content to obtain a final version.

Results

Experts identified a gap regarding assessment of hand/finger coordination. The CCS final version is composed of 6 complementary tests of coordination: finger-to-nose, arm-trunk, finger, lower extremity, and 2- and 4-limb interlimb coordination. Constructs include spatial and temporal variables totaling 69 points. Higher scores indicate better performance.

Conclusions

The CCS may be an important, understandable and feasible outcome measure to assess spatial and temporal coordination. CCS measurement properties are presented in the companion article.
Comparison of Screw Quantity and Placement of Metacarpal Fracture Fixation: A Biomechanical Study
Authors: Canton Stephen P. , Dadi Srujan , Anthony Austin , Black Ryan T. , Clancy Michael , Fowler John R.
Published: December 2020

Background

It is recommended to have 6 bicortical screws for plate fixation of long bone fractures; however, many metacarpal fractures do not allow 6 screws due to size limitations and proximity of crucial anatomical structures. The purpose of this biomechanical study was to determine whether the mechanical properties of a 4-screw nonlocking construct are noninferior to those of a 6-screw nonlocking construct.

Methods

Metacarpal sawbones were used to simulate a midshaft, transverse fracture. Nonlocking bicortical screws were placed in the 6-hole plate, and the metacarpals were randomly assigned to 2 equal study groups: (1) 4 screws, 2 on either side of the fracture (4S); and (2) 6 screws, 3 on either side of the fracture (6S). The metacarpals were tested in a cyclic loading mode and load to failure in a cantilever bending mode.

Results

Maximum deflection was significantly higher for 4S compared with 6S. Cyclic root mean square (RMS) was also significantly greater for 4S at 70 and 100 N. There were no statistically significant differences observed between the 2 constructs for maximum bending load, bending stiffness, and cyclic RMS at 40 N. The maximum bending load in 4S and 6S was 245.6 ± 37.9 N and 230.8 ± 41.9 N, respectively; 4S was noninferior and not superior to 6S. Noninferiority testing was inconclusive for bending stiffness.

Conclusions

A 4-screw bicortical nonlocking construct is noninferior to a 6-screw bicortical nonlocking construct for fixation of metacarpal fractures, which may be advantageous to minimize disruption of soft tissues while maintaining sufficient construct stability.
Current practices and factors affecting evidence-based occupational therapy practice for patients with dementia in Japan
Authors: Hasegawa Ai , Takashima Risa , Yoshida Kazuki , Sawamura Daisuke , Murata Waka , Sakai Shinya
Published: December 2020

Objective/background

The rapidly increasing incidence of patients with dementia in Japan is creating an urgent demand for evidence-based occupational therapy (EBOT), which has been reported to improve clinical efficacy. This study aimed to examine the current practice of EBOT for patients with dementia in Japan and clarify factors influencing its application.

Methods

We conducted an anonymous, self-administered questionnaire survey by mail. The participants were 432 occupational therapists treating patients with dementia at 432 designated medical institutions nationwide. Descriptive statistics were calculated, and multiple regression analysis was performed to clarify the factors influencing the present application of EBOT.

Results

The response rate was 31.3%. Among the participants, 46.3% responded ‘somewhat frequently’ or more (5, 6, and 7 on a 7-grade scale) to a question on the frequency of practice of EBOT. Using multiple regression analysis with the stepwise method, we selected the model with the highest degree of fit. This model extracted three factors, namely, ability to understand scientific papers, sufficiency of means of getting information, and availability of advice, which had standardized partial regression coefficients (β) of 0.419, 0.214, and 0.158, respectively.

Conclusions

The three factors extracted using the multiple regression analysis indicate that in order to encourage EBOT for patients with dementia, occupational therapists need to acquire reading comprehension skills, so that they can assess the quality of scientific papers. Furthermore, it is important to create environments where they have access to publications and can discuss research with superiors and colleagues.
Co-Researching With Children in the Time of COVID-19: Shifting the Narrative on Methodologies to Generate Knowledge
Authors: Cuevas-Parra Patricio
Published: December 2020

Children and young people’s participation in decision-making has substantially increased in the last 3 decades; although, their participation in research has been more problematic due to traditional views that exclude them from the realm of knowledge generation. This article critically reflects on the way that 12 children and young people engaged as co-researchers in an intergenerational research project that explored the perspectives of children and young people during the COVID-19 outbreak. Drawing upon the experiences of these child researchers, the author discusses the methodological and ethical complexities of their engagement—which is already a disputed topic—in the context of the global health crisis characterized by lockdowns, isolation, and social distancing. The author outlines the strategic role that the child researchers had in reaching their peers and collecting relevant data, which would not have been possible without them, due to the circumstances of the pandemic. Furthermore, it is argued the need to rethink the role of children and young people as partners in research, especially in times of crises, and to embrace the epistemological position that they are able to deliver quality research results. The generation of collective knowledge is intertwined with relations, situations, and contexts, and together they influence each other, making the research project dynamic and unconceivable without the child researchers.
Research on aerodynamic characteristics of two-stage axial micro air turbine spindle for small parts machining
Authors: Jiang Liu , Zhiping Guo , Shujing Miao , Xiangxin He , Xinyu Zhu
Published: December 2020

In order to meet the requirements of output torque, efficiency and compact shape of micro-spindles for small parts machining, a two-stage axial micro air turbine spindle with an axial inlet and outlet is proposed. Based on the k-ω turbulence model of SST, the flow field and operation characteristics of the two-stage axial micro air turbine spindle were studied using computational fluid dynamics (CFD) combined with an experimental study. We obtained the air turbine spindle under different working conditions of the loss and torque characteristics. When the inlet pressure was 300 KPa, the output speed of the two-stage turbine was 100,000 rpm, 9% higher than that of a single-stage turbine output torque. The total torque reached 6.39 N·mm, and the maximum efficiency of the turbine and the spindle were 42.2% and 32.3%, respectively. Through the research on the innovative structure of the two-stage axial micro air turbine spindle, the overall performance of the principle prototype has been significantly improved and the problems of insufficient output torque and low working efficiency in high-speed micro-machining can be solved practically, which laid a solid foundation for improving the machining efficiency of small parts and reducing the size of micro machine tool.
XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib
Authors: Ali Reem , Alblihy Adel , Toss Michael S. , Algethami Mashael , Al Sunni Rabab , Green Andrew R. , Rakha Emad A. , Madhusudan Srinivasan
Published: December 2020

Background:

PARP inhibitor (PARPi) monotherapy is a new strategy in BRCA germ-line deficient triple negative breast cancer (TNBC). However, not all patients respond, and the development of resistance limits the use of PARPi monotherapy. Therefore, the development of alternative synthetic lethality strategy, including in sporadic TNBC, is a priority. XRCC1, a key player in base excision repair, single strand break repair, nucleotide excision repair and alternative non-homologous end joining, interacts with PARP1 and coordinates DNA repair. ATR, ATM and Wee1 have essential roles in DNA repair and cell cycle regulation.

Methods:

Highly selective inhibitors of ATR (AZD6738), ATM (AZ31) and Wee1 (AZD1775) either alone or in combination with olaparib were tested for synthetic lethality in XRCC1 deficient TNBC or HeLa cells. Clinicopathological significance of ATR, ATM or Wee1 co-expression in XRCC1 proficient or deficient tumours was evaluated in a large cohort of 1650 human breast cancers.

Results:

ATR (AZD6738), ATM (AZ31) or Wee1 (AZD1775) monotherapy was selectively toxic in XRCC1 deficient cells. Selective synergistic toxicity was evident when olaparib was combined with AZD6738, AZ31 or AZD1775. The most potent synergistic interaction was evident with the AZD6738 and olaparib combination therapy. In clinical cohorts, ATR, ATM or Wee1 overexpression in XRCC1 deficient breast cancer was associated with poor outcomes.

Conclusion:

XRCC1 stratified DNA repair targeted combinatorial approach is feasible and warrants further clinical evaluation in breast cancer.
Reenergizing Through Angel Customers: Cross-Cultural Validation of Customer-Driven Employee Citizenship Behavior
Authors: Ma Emily , Wang Yao-Chin , Qu Hailin
Published: December 2020

This study proposes and examines the role server-friendly customers play in the customer-employee exchange stage of service encounters, and how customer-employee exchange relates to employee organizational citizenship behaviors toward customers, colleagues, and hotel organizations. To further explain how service employees could reenergize through the psychological resources gained from server-friendly customers at the point of customer-employee exchange, conservation of resources theory was applied. Hotel employees in the United States and China were sampled to jointly examine our proposed model. Findings of this study contribute valuable theoretical implications by emphasizing the role of customer-employee exchange in the formation of employee citizenship behaviors, as well as practical implications with regard to mentoring employees, thus strategically reenergizing psychological resources and obtaining tacit knowledge of citizenship behavior and its practice.
Disseminated focal 18F-fluoro-deoxyglucose uptake upon granulocyte colony-stimulating factor therapy mimicking malignant bone infiltration: case report of a patient with very severe aplastic anemia
Authors: Horvath Lena , Seeber Andreas , Uprimny Christian , Wolf Dominik , Nachbaur David , Kocher Florian
Published: December 2020

Combined 18F-fluoro-deoxyglucose ([18F]FDG) positron emission tomography and computed tomography ([18F]FDG-PET/CT) is increasingly used for the diagnostic and therapeutic management of hematologic and non-hematologic malignancies. Here, we describe a unique case of a patient presenting with very severe aplastic anemia and a mediastinal mass showing disseminated hypermetabolic lesions of the bones after receiving granulocyte colony-stimulating factor (G-CSF), highly suspicious for disseminated metastatic lesions. A 71-year-old patient presented with a 3 week history of dyspnea and fatigue. Blood tests showed severe pancytopenia and iliac crest bone marrow biopsy revealed an extensively hypoplastic bone marrow. Diagnostic work-up by histology, conventional cytogenetics and flow cytometry confirmed the diagnosis of very severe aplastic anemia. Besides blood transfusions, the patient was treated with G-CSF. Furthermore, computed tomography revealed a suspect mass in the anterior mediastinum, presenting with moderate glucose metabolism in the subsequent [18F]FDG-PET/CT scan. In addition, multiple disseminated and highly metabolic bone lesions of primarily the ribs were detected, suspicious of malignant bone infiltration. Since physiologic bone marrow activation by G-CSF-stimulation could not be ruled out, G-CSF therapy was interrupted to repeat the PET/CT scan 10 days later. On the second [18F]FDG-PET/CT the moderately hypermetabolic mediastinal mass persisted. However, the initially FDG-avid bone lesions almost completely resolved, rendering the diagnosis of G-CSF-induced bone marrow hypermetabolism very likely without the need for further invasive diagnostic procedures. The mediastinal mass was thereafter histologically verified as thymoma. Interpretation of [18F]FDG-PET/CT in patients with aplastic anemia may be complicated by the frequent therapeutic use of G-CSF. With G-CSF, islets of residual bone marrow activity can be visualized on [18F]FDG-PET/CT images that might be misinterpreted as malignant bone infiltration. Repeating PET/CT scan after G-CSF discontinuation can prevent unnecessary invasive diagnostic procedures in these patients.
Auditory Rate Perception Displays a Positive Serial Dependence
Authors: Motala Aysha , Zhang Huihui , Alais David
Published: December 2020

We investigated perceived timing in auditory rate perception using a reproduction task. The study aimed to test (a) whether central tendency occurs in rate perception, as shown for interval timing, and (b) whether rate is perceived independently on each trial or shows a serial dependence, as shown for other perceptual attributes. Participants were well able to indicate perceived rate as reproduced and presented rates were linearly related with a slope that approached unity, although tapping significantly overestimated presented rates. While the slopes approached unity, they were significantly less than 1, indicating a central tendency in which reproduced rates tended towards the mean of the presented range. We tested for serial dependency by seeing if current trial rate reproductions depended on the preceding rate. In two conditions, a positive dependence was observed. A third condition in which participants withheld responses on every second trial produced a negative dependency. These results suggest separate components of serial dependence linked to stimulus and response: Withholding responses reveals a negative perceptual effect, whereas making responses adds a stronger positive effect that is postperceptual and makes the combined effect positive. Together, these data show that auditory rate perception exhibits both central tendency and serial dependence effects.
Filling the Empty: An Unnoticed Pun in James 2.20-23
Authors: Gabrielson Timothy A.
Published: December 2020

The style of James’s epistle receives much acclaim. Among other techniques like alliteration and rhythm, James enjoys a play on words. I propose that James puns on the concept of “filling” with three words in Jas 2.20-23: κενέ (“empty,” v. 20), ἐτελειώϑη (“be complete,” v. 22), and ἐπληρώϑη (“be fulfilled,” v. 23), to the effect that an “empty” person is told to learn from the “filled out” faith of Abraham whose willingness to sacrifice Isaac “fulfilled” the earlier pronouncement about his righteousness. This suggestion builds on discussions concerning the relationship between vv. 20, 22, and vv. 22-23. It also draws out often neglected connotations of τελειόω. This wordplay fits into a wider “completion” theme in James and may even have been picked up by the Shepherd of Hermas and the Didache.
Assessment of a Discourse Workshop: Design, Implementation, and Outcomes
Authors: Grossmann Becky
Published: December 2020

This project addresses the problem of Bible translations that appear wooden as a result of following a source language text too closely. It examines what effect a discourse workshop focusing on receptor language structures had on translators and their revisions to selected Scripture texts in three translation projects in Liberia. The article evaluates the process, material, and outcomes of the workshop and gives recommendations for improvement and further training.
K-pop fan labor and an alternative creative industry: A case study of GOT7 Chinese fans
Authors: Sun Meicheng
Published: December 2020

Korean popular music or K-pop has achieved popularity among global audiences. The uniqueness of K-pop fan culture has helped to shape the success of the K-pop industry. Through a case study of Chinese fan labor vis-à-vis K-pop male idol group GOT7, the author notes three types of K-pop fan labor: specialized labor, managerial labor, and unskilled labor. This research argues that fan labor transforms the K-pop industry into an alternative creative industry because fan labor as creative labor is an indispensable part of the K-pop industry. Fan labor is utilized to distinguish fans from non-fans, and to draw boundaries between the grateful, more enthusiastic fans and the casual self-proclaimed fans who do not contribute to fandom or their idols’ success. These Chinese K-pop fans comply with the K-pop industry’s commodification of culture, are exploited by the K-pop industry, and seek empowerment in the K-pop production and distribution process. This paper’s exploration of fan labor, based on the author’s participant observations and in-depth interviews, will thus contribute to studies on the creative industries, creative labor, fandom, and the transnational flows of popular culture.
Exploring the Interplay of Green Human Resource Management, Employee Green Behavior, and Personal Moral Norms
Authors: Fawehinmi Olawole , Yusliza M. Y. , Wan Kasim Wan Zulkifli , Mohamad Zaleha , Sofian Abdul Halim Muhammad Abi
Published: December 2020

The rapid degradation of today’s environment has required the governments and organizations to introduce effective countermeasures. Governments have enforced green policies, and organizations have drawn on these policies to implement environmentally friendly workplace practices. The success of these practices is very much dependent on the employees and the extent of their green behavior. As such, there is a need to determine whether green behavior can be positively influenced by other variables. One of the suggested influencing variables is green human resource management (HRM). Another variable with the potential mediating effect is personal moral norms (PMN). Also, there is a need to examine the interplay of green HRM, employee green behavior (EGB), and PMN within the context of higher education institutions (HEIs) as they also take responsibility for protecting the environment. It is believed that to date, studies of this nature have not involved academics at HEIs in Malaysia. This study aims to examine the mechanism by which green HRM affects EGB of academics at Malaysian HEIs through PMN as mediator. Data were collected through a cross-sectional quantitative survey among 425 academics at five research universities in Malaysia. The analysis was performed using Smart PLS version 3.2.8. There was a positive significant relationship between green HRM and PMN and a positive significant relationship between PMN and EGB. Hence, green HRM had an effect on EGB through the mediating role of PMN. However, there was no significant direct relationship between green HRM and EGB. Other studies have investigated the effects of several mediating variables in the relationship between green HRM and EGB; however, the effect of one variable—PMN—has not been examined. This study, as it investigates the vital aspect of behavioral formation, is believed to be the first study that examines the mediating role of PMN in the interplay between green HRM and EGB of academics. The theoretical and practical implications are discussed in this study.
An Unusual Cause of an Intraperitoneal Bleed: Bleeding Hepatic Artery Pseudoaneurysm Due to an Eroding Cholecystitis
Authors: Sawalha Khalid , Kunnumpurath Anthony , McCann Ronald
Published: December 2020

An 80-year-old male patient presented with sepsis secondary to infected central line which was placed for native aortic valve endocarditis. He also had melena and abdominal pain prior to his presentation. Abdominal computed tomography (CT) was done, which showed cholelithiasis. Esophagogastroduodenoscopy was also done with no source of bleeding identified. Later, he developed hemodynamic instability requiring aggressive fluid resuscitation and multiple packed blood cell transfusions. In view of his hemodynamic instability, a repeat abdominal CT scan showed air droplets within the gallbladder pneumobilia, ascites, diverticulosis, and a bleeding infrahepatic hematoma measuring 6 × 10 cm, which was not on his prior scan 2 days prior. A mesenteric arteriogram was performed that identified an aneurysm of the right hepatic artery with no active bleeding; therefore, it was coiled. Due to his continued clinical decompensation, he underwent an urgent open cholecystectomy, in which serosanguineous fluid, cholecystocolic fistula, and old clot related to his previous bleed were encountered. However, control of bleeding was difficult, and the patient expired. We report this case of right hepatic artery aneurysm that we believe its etiology was related to eroding cholecystitis.
Electrolyte Replacement in Bartter Syndrome With Abnormal Small Bowel: A Case Report
Authors: Sobash Philip T. , Vedala Krishna , McClain Charles M. , Oster Caleb
Published: December 2020

Bartter syndrome is a rare disorder that is characterized by weakness and fatigue with laboratory findings of hypokalemia and metabolic alkalosis with increased aldosterone and angiotensin. It specifically acts on the ascending loop of Henle, characterized by miscoded proteins affecting NaCl transports and channels. Patients will require replacement of potassium and sometimes magnesium due to the kidneys’ inability to reabsorb these ions. So what happens when the body’s other primary mechanism of absorption of these elements are taken out? In this article, we present the case of a 47-year-old woman with Bartter syndrome on oral potassium 40 mg BID (twice a day) and magnesium oxide 800 TID (thrice a day), who recently had a small bowel resection that required intravenous potassium and magnesium throughout her hospital admission. Significant questions arose as to how her electrolytes should be managed, given her unusual presentation with rare underlying disorder. We discuss the implications of her bowel resection in the context of Bartter syndrome and our views on her future course based on available literature.
The Lebanese Evangelical Church’s Response to the Syrian Crisis: The Shaping of Identity
Authors: Gustafson Scott
Published: December 2020

The Lebanese church has experienced unprecedented challenges as Syrian refugees began flooding the country in 2011. This article attempts to discern the approaches to identity, strategy, and partnership that evolved for Lebanese evangelicals as the church found itself in the epicenter of Muslim emigration from war-torn neighbors. It discusses how the history of the Lebanese church prepared it for the most recent crisis and led to the development of unique outreach strategies and the intentional cultivation of robust partnerships. Finally, it demonstrates how these developments have contributed to the Lebanese evangelical church’s explosive growth in the last decade.
Overseas Ministries and the Subversion of Theological Education
Authors: Walls Andrew F.
Published: December 2020

Recounting the founding purpose and later development of the Overseas Ministries Study Center, Walls characterizes OMSC as a “a niche branch of theological education” that has kept pace with the dramatic changes in the World Christian movement during the twentieth century. In light of these changes, Walls argues for the need of a renewed "World Christian consciousness" across the theological curriculum in the West. He offers four “subversive statements” from his own field of Christian history that point the way forward.
Regional differences in resilience of social and physical systems: Case study of Puerto Rico after Hurricane Maria
Authors: Yabe Takahiro , Rao P Suresh C , Ukkusuri Satish V
Published: December 2020

Physical infrastructure networks in diverse urban settlements are designed to be robust and reliable, while the socio-economic systems offer the necessary adaptive capacity at household, city, and regional scales to recover from major service disruptions resulting from disasters. Here, our urban resilience analyses are based on exploring explicit links between the physical infrastructure/assets and the socio-economic systems. Increased availability of high-quality data from mobile devices allows quantification of diverse socio-economic metrics and thus enables tracking city- and regional-scale community recovery from disasters. Here, recovery trajectories for five regions within Puerto Rico island with differences in socio-economic status (e.g., median income) after Hurricanes Irma and Maria are analyzed using large-scale mobility data and are combined with earlier synthesis of seven global cities based on capital portfolio analysis. Systemic inequalities are manifested in highly variable ability to cope with chronic shocks and recovery from extreme events. Island urban communities face the geographic-isolation effect, legacy socioeconomic constraints, and chronic inefficiencies in governance, all of which delay recovery from disasters. Hurricane recovery efforts include two types of responses. First, in larger urban areas, households use their social ties and financial resources to evacuate to larger cities and return when damaged facilities and infrastructure are repaired. Second, smaller urban communities are already adapted to coping with inadequate critical services and experience disproportionate impacts of disasters. Lacking socio-economic resources, such communities self-organize to access local and external resources and actively engage in repairing and rebuilding damaged facilities. However, recovery is much slower than their counterparts in larger cities. Given the interdependencies of connected social and physical systems and cross-scale feedbacks, such inequalities must be addressed at both city and regional scales to continue progress in urban community preparedness for and recovery from disasters.
Ketamine Normalizes the Structural Alterations of Inferior Frontal Gyrus in Depression
Authors: Dai Dan , Lacadie Cheryl M. , Holmes Sophie E. , Cool Ryan , Anticevic Alan , Averill Chris , Abdallah Chadi , Esterlis Irina
Published: December 2020

Background

Ketamine is a novel fast-acting antidepressant. Acute ketamine treatment can reverse microstructure deficits and normalize functional alterations in the brain, but little is known about the impacts of ketamine on brain volumes in individuals with depression.

Methods

We used 3 T magnetic resonance imaging (MRI) and tensorbased morphological methods to investigate the regional volume differences for 29 healthy control (HC) subjects and 21 subjects with major depressive disorder (MDD), including 10 subjects with comorbid post-traumatic stress disorder (PTSD). All the subjects participated in MRI scanning before and 24 h post intravenous ketamine infusion. The effects of acute ketamine administration on HC, MDD, and MDD/PTSD groups were examined separately by whole-brain voxel-wise t-tests.

Results

Our data showed smaller volume of inferior frontal gyrus (IFG, opercular part) in MDD and MDD/PTSD subjects compared to HC, and a significant correlation between opercular IFG volume and depressive severity in MDD subjects only. Ketamine administration normalized the structural alterations of opercular IFG in both MDD and MDD/PTSD groups, and significantly improved depressive and PTSD symptoms. Twenty-four hours after a single ketamine infusion, there were two clusters of voxels with volume changes in MDD subjects, including significantly increased volumes of opercular IFG. No significant structural alterations were found in the MDD/PTSD or HC groups.

Conclusion

These findings provide direct evidence that acute ketamine administration can normalize structural alterations associated with depression and highlight the importance of IFG in the guidance of future therapeutic targets.