bluuebunny/crossref_metadata_2025 huggingface dataset:
SMB chromatography design using profile advancement factors, miniplant data, and rate‐based process simulation
Authors: Feist Shawn D. , Hasabnis Yogesh , Pynnonen Bruce W. , Frank Timothy C.
Published: August 2009

This article describes a systematic miniplant‐based approach to rapid development of simulated moving bed (SMB) chromatography applications. The methodology involves analysis of single‐column pulse tests to screen adsorbents and operating conditions and to determine initial values of profile advancement factors used to specify flow rates for an initial SMB miniplant experiment. A lumped‐parameter linear driving force rate‐based model is developed by fitting process data from a single miniplant run. The data are fit in a two‐step procedure involving initial determination of effective adsorption isotherm constants as best‐fit parameters with subsequent adjustment of calculated mass transfer coefficients to refine the data fit. The resulting simulation is used to guide further miniplant work and minimize experimental effort. The methodology is illustrated with miniplant data for a binary protein separation showing excellent agreement between model results and process data generated over a wide range of operating conditions. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Classifying functional manifestations of ectodermal dysplasias
Authors: Simeonsson Rune J.
Published: August 2009

Ectodermal dysplasias (ED) encompass more than 200 conditions involving some combination of disorders of hair, nails, teeth, and sweat glands. The incidence of ED is relatively rare affecting about 7 of 10,000 births [Itin and Fistarol (2004)]. Individuals manifesting ED present with a wide range of disorders involving hair, nails, teeth, and sweat glands and in many cases other characteristics as well. The complex nature of the disorder has presented challenges for clinical practice and required the involvement of multiple approaches and disciplines. It has also resulted in significant research initiatives on cause and symptomatology. A significant challenge has been the search for comprehensive documentation of the varied and complex manifestations associated with ED. Existing classification systems of ED have focused on physiological and structural dimensions. Classification approaches with a broader focus including characteristics of functioning in persons with ED could facilitate clinical work and research initiatives. In this context, the potential utility of available classifications that address functioning and disability would be appropriate to consider in the search for a consensus classification of ED. To that end, the purpose of this article is to (a) review the status of classification of ED, (b) provide a brief overview of the International Classification of Functioning, Disability and Health‐Children and Youth, ICF‐CY [World Health Organization (2007); International Classification of Functioning, Disability and Health‐Children and Youth. Geneva: WHO.], and (c) identify possible contributions of the ICF‐CY to classification of ED's. © 2009 Wiley‐Liss, Inc.
Synthesis, structural characterization and electrochemical recognition of metal ions of two new ferrocenylhydrazone‐based receptors
Authors: Qiao Chunjie , Li Jie , Xu Yan , Guo Shuyan , Qi Xue , Fan Yaoting
Published: August 2009

Two new ferrocenylhydrazone‐based receptors FcL1 and FcL2 were prepared and the X‐ray crystal structure of FcL1 was described. The electrochemical studies reveal that the receptor FcL1 is responsive to Hg2+ and Cr3+, whereas, receptor FcL2 only responsive to Hg2+. The maximum electrochemical shift of FcL1 for Cr3+ is about 56 mV. Copyright © 2009 John Wiley & Sons, Ltd.
Influence of the filler CaCO3 on the cure kinetic of the epoxy network diglycidyl ether of bisphenol a (BADGE n = 0) with isophorone diamine
Authors: Fraga Francisco , Vázquez Ivan , Rodríguez‐Núñez Eugenio , Martínez‐Ageitos José Manuel , Miragaya Javier
Published: August 2009

The influence of the presence of CaCO3 on the cure reaction of the epoxy network diglycidyl ether of bisphenol A with isophorone diamine has been studied. The total enthalpy of reaction, the glass transition temperature and the partial enthalpies at different isothermal temperatures have been determined using differential scanning calorimetry (DSC) in dynamic and isothermal mode. A kinetic model accounting the influence of the diffusion of the reactive groups at high conversions was used. All the kinetic parameters have been compared with those of the system without filler (CaCO3). © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Ultrastructure Changes of Cardiac Lymphatics During Cardiac Fibrosis in Hypertensive Rats
Authors: Li Xiaodong , Shimada Tatsuo , Zhang Yafang , Zhou Xianli , Zhao Linghui
Published: August 2009

Hypertension is one of the most common diseases that induce a series of pathological changes in different organs of the human body, especially in the heart. There is a wealth of evidence about blood vessels in hypertensive myocardium, but little is known about structural changes in the cardiac lymphatic system. To clarify the changes in structure of the cardiac lymphatic system during hypertension, we developed a hypertension animal model with Dahl S rats and we used Dahl R rats as the control group. We examined the expression of collagen fibers, atrial natriuretic peptide, connexin43, and LYVE‐1 in the rat heart by immunohistochemistry. The ultrastructure of the cardiac lymphatics was detected by transmission electron microscopy and scanning electron microscopy. We demonstrated extensive lymphatic fibrosis in the hearts of the Dahl S hypertension group, characterized by increased thin collagen fibrils that connected with the lymphatics directly. Ultrastructural changes in the cardiac lymphatic endothelium such as an increase of vesicles and occurrence of vacuoles, active exocytosis, and cytoplasmic processes, restored the draining of tissue fluid. Our study suggests that during hypertension, the changes in structure of the cardiac lymphatics may be one important factor involved in cardiac fibrosis. Therefore, the lymphatics may be a possible target for reducing fibrosis in the treatment of hypertension. Anat Rec, 2009. © 2009 Wiley‐Liss, Inc.
Interactions of Serotoninergic, Cholinergic, and Tachykinin‐Containing Nerve Elements in the Rabbit Small Intestine
Authors: Dénes Viktoria , Wilhelm Marta , NÉMeth Agnes , GÁBriel Robert
Published: August 2009

This report presents novel results on the effects of serotonin (5‐HT) on longitudinal muscle contractions in the rabbit ileum and the interactions of serotonin with some neuronal elements of the myenteric plexus. We showed previously that serotonin‐triggered contractions involved two mechanisms in the rabbit ileum: neuronal excitation (via 5‐HT2receptors in the neurons) and direct muscular stimulation (via 5‐HT4receptors in the muscle). Here, we focus on the neuronal 5‐HT2receptor pathway and report further pharmacological and immunocytochemical data clarifying the details of the mechanisms. We observed that antagonists for neurokinin (NK1 and NK2) receptors partially blocked the serotonin response, but NK3 receptor antagonists had no effect. Pretreatment by atropine (ATR) eliminated the NK1 receptor antagonist resistant contractions. In contrast, the NK1 antagonist did not depress the ATR‐resistant contraction when ATR was added first. 5‐HT2receptor agonist‐induced contractions were partially suppressed by ATR, hexamethonium, and NK1 or NK2 receptor antagonists. In conclusion, serotonin acting through 5‐HT2receptors could stimulate interneurons and excitatory motor neurons. Immunocytochemical staining revealed an extensive tachykinin‐immunoreactive (IR) network in the myenteric plexus. Approximately 52% of all myenteric neurons were labeled. 5‐HT‐IR fibers could be detected around both choline acetyltransferase‐ and tachykinin‐IR cells, suggesting functional relationships between them. Consistent with our pharmacological observations, we found that immunopositive nerve elements for 5‐HT2Areceptor and double‐labeled immunostaining revealed a remarkable overlap between tachykinin‐IR neurons and 5‐HT2A‐IR elements. Anat Rec, 2009. © 2009 Wiley‐Liss, Inc.
Microbioreactor array for full‐factorial analysis of provision of multiple soluble factors in cellular microenvironments
Authors: Titmarsh Drew , Cooper‐White Justin
Published: August 2009

We report a scalable microbioreactor architecture which uses nested dilution structures to generate a full‐factorial array of cell culture conditions. The proof‐of‐concept microbioreactor array produces all combinations of three concentration levels of two soluble factors (32 = 9 unique conditions in total). The full‐factorial design is especially useful in optimizing soluble factor treatments and elucidating interaction effects between factors which are otherwise difficult to deconvolute. By nesting hierarchical levels of dilution structures, and designing the device purely by resistive flow (no valves are required), suitable diffusive mixing of growth factors up to 40 kDa is achieved such that the nine culture conditions can be generated and maintained from a minimal number of stock solutions. Biotechnol. Bioeng. 2009; 104: 1240–1244. © 2009 Wiley Periodicals, Inc.
Substrate uptake, phosphorus repression, and effect of seed culture on glycopeptide antibiotic production: Process model development and experimental validation
Authors: Maiti Soumen K. , Singh Kamaleshwar P. , Lantz Anna Eliasson , Bhushan Mani , Wangikar Pramod P.
Published: August 2009

Actinomycetes, the soil borne bacteria which exhibit filamentous growth, are known for their ability to produce a variety of secondary metabolites including antibiotics. Industrial scale production of such antibiotics is typically carried out in a multi‐substrate medium where the product formation may experience catabolite repression by one or more of the substrates. Availability of reliable process models is a key bottleneck in optimization of such processes. Here we present a structured kinetic model to describe the growth, substrate uptake and product formation for the glycopeptide antibiotic producer strain Amycolatopsis balhimycina DSM5908. The model is based on the premise that the organism is an optimal strategist and that the various metabolic pathways are regulated via key rate limiting enzymes. Further, the model accounts for substrate inhibition and catabolite repression. The model is also able to predict key phenomena such as simultaneous uptake of glucose and glycerol but with different specific uptake rates, and inhibition of glycopeptide production by high intracellular phosphate levels. The model is successfully applied to both production and seed medium with varying compositions and hence has good predictive ability over a variety of operating conditions. The model parameters are estimated via a well‐designed experimental plan. Adequacy of the proposed model was established via checking the model sensitivity to its parameters and confidence interval calculations. The model may have applications in optimizing seed transfer, medium composition, and feeding strategy for maximizing production. Biotechnol. Bioeng. 2010;105: 109–120. © 2009 Wiley Periodicals, Inc.
Stenting of aortic coarctation and exercise‐induced hypertension in the young
Authors: De Caro Enrico , Spadoni Isabella , Crepaz Roberto , Saitta Michele , Trocchio Gianluca , MG Calevo , Pongiglione Giacomo
Published: August 2009

Objectives:

To evaluate whether the stenting of aortic coarctation enhance the risk of exercise‐induced hypertension (EIH).

Background:

There is the theoretical concern that aortic stents may cause increased aortic wall impedance and therefore systolic hypertension during exercise.

Methods:

Blood pressure and the Doppler derived peak and mean systolic pressure gradient (PSG and MSG) across the distal aorta at the peak of exercise were evaluated in young patients (mean age 14 ± 3 years)with aortic coarctation successfully treated with surgery or with stent implantation at least 1 year before the test. Only patients who reached the 85% maximal predicted heart rate or whose exercise test was interrupted because of severe hypertension, and in whom significant aortic narrowings were excluded by a MRI or a CT scan performed in the six months preceding the exercise test were included in the study.

Results:

Seventeen patients formed the surgery‐group, while 15 patients the stent‐group. Patients in surgery‐group were younger at coarctation repair and with a longer follow‐up than those in stent‐group. No difference was present regarding age, body surface area, gender, and presence, and degree of mildly hypoplastic aortic segments between the two groups as well as between patients with or without EIH. EIH was found in 35% of surgery‐group patients and in 33% of stent‐group patients. PSG and MSG were similar in the patients with or without EIH.

Conclusions:

EIH can be found in a high number of young patients successfully treated for aortic coarctation but at intermediate follow‐up stent implantation does not seem to enhance the risk of EIH. © 2010 Wiley‐Liss, Inc.
Gold Manno‐Glyconanoparticles: Multivalent Systems to Block HIV‐1 gp120 Binding to the Lectin DC‐SIGN
Authors: Martínez‐Ávila Olga , Hijazi Karolin , Marradi Marco , Clavel Caroline , Campion Colin , Kelly Charles , Penadés Soledad
Published: August 2009

The HIV envelope glycoprotein gp120 takes advantage of the high‐mannose clusters on its surface to target the C‐type lectin dendritic cell‐specific intracellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) on dendritic cells. Mimicking the cluster presentation of oligomannosides on the virus surface is a strategy for designing carbohydrate‐based antiviral agents. Bio‐inspired by the cluster presentation of gp120, we have designed and prepared a small library of multivalent water‐soluble gold glyconanoparticles (manno‐GNPs) presenting truncated (oligo)mannosides of the high‐mannose undecasaccharide Man9GlcNAc2 and have tested them as inhibitors of DC‐SIGN binding to gp120. These glyconanoparticles are ligands for DC‐SIGN, which also interacts in the early steps of infection with a large number of pathogens through specific recognition of associated glycans. (Oligo)mannosides endowed with different spacers ending in thiol groups, which enable attachment of the glycoconjugates to the gold surface, have been prepared. manno‐GNPs with different spacers and variable density of mannose (oligo)saccharides have been obtained and characterized. Surface plasmon resonance (SPR) experiments with selected manno‐GNPs have been performed to study their inhibition potency towards DC‐SIGN binding to gp120. The tested manno‐GNPs completely inhibit the binding from the micro‐ to the nanomolar range, while the corresponding monovalent mannosides require millimolar concentrations. manno‐GNPs containing the disaccharide Manα1‐2Manα are the best inhibitors, showing more than 20 000‐fold increased activity (100 % inhibition at 115 nM) compared to the corresponding monomeric disaccharide (100 % inhibition at 2.2 mM). Furthermore, increasing the density of dimannoside on the gold platform from 50 to 100 % does not improve the level of inhibition.
ChemInform Abstract: Structural and Dynamic Properties of BaInGeH: A Rare Solid‐State Indium Hydride.
Authors: Evans Michael J. , Kranak Verina F. , Garcia‐Garcia Francisco J. , Holland Gregory P. , Daemen Luke L. , Proffen Thomas , Lee Myeong H. , Sankey Otto F. , Haussermann Ulrich
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Link Between Giant Molybdenum Oxide Based Ions and Derived Keggin Structure: Modular Assemblies Based on the [BW11O39]9‐ Ion and Pentagonal {M′M5} Units (M′: W; M: Mo, W).
Authors: Leclerc‐Laronze Nathalie , Marrot Jerome , Thouvenot Rene , Cadot Emmanuel
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Perfect Double Role of CF3 Groups in Activating Substrates and Stabilizing Adducts: The Chiral Broensted Acid‐Catalyzed Direct Arylation of Trifluoromethyl Ketones.
Authors: Nie Jing , Zhang Guang‐Wu , Wang Lian , Fu Aiping , Zheng Yan , Ma Jun‐An
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acetate‐Promoted Aldol‐Type Reaction: Scope and Reactivity of Acetates and Aldehydes.
Authors: Kim Dong Hyeon , Rahman A. F. M. Motiur , Jeong Byeong‐Seon , Lee Eung Seok , Jahng Yurngdong
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient One‐Pot Synthesis of Functionalized (E)‐2‐Arylvinyl Bromides from (E)‐4‐(2‐Bromovinyl)phenyl Acetate.
Authors: Jiang Yu Bo , Kuang Chun Xiang
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: TMPZnCl·LiCl: A New Active Selective Base for the Directed Zincation of Sensitive Aromatics and Heteroaromatics.
Authors: Mosrin Marc , Knochel Paul
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Photochemical Characteristics of Amphiphilic Enediyne Dendrimers.
Authors: Yoshimura Nao , Momotake Atsuya , Shinohara Yoshihiro , Takahashi Kayori , Nagahata Ritsuko , Nishimura Yoshinobu , Arai Tatsuo
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Method for the Preparation of Differentiated trans‐1,2‐Diol Derivatives with Enantio‐ and Diastereocontrol.
Authors: Lim Sang Min , Hill Nicholas , Myers Andrew G.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Continuous Flow Synthesis of Hydroxamic Acids and Suberoylanilide Hydroxamic Acid (VII) Preparation.
Authors: Riva Elena , Gagliardi Stefania , Mazzoni Caterina , Passarella Daniele , Rencurosi Anna , Vigo Daniele , Martinelli Marisa
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of Metalated Cyclobutyl Derivatives.
Authors: Tsoglin Einav , Chechik Helena , Karseboom Guy , Chinkov Nicka , Stanger Amnon , Marek Ilan
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multicomponent Type II Anion Relay Chemistry (ARC): One‐Pot Syntheses of 2,3‐Disubstituted Furans and Thiophenes.
Authors: Devarie‐Baez Nelmi O. , Kim Won‐Suk , Smith Amos B. III , Xian Ming
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pt(II)‐Catalyzed Hydroarylation Reaction of Alkynes with Pyrroles and Furans.
Authors: Oyamada Juzo , Kitamura Tsugio
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Novel Analogues of Trifenagrel.
Authors: Nagarapu Lingaiah , Aneesa Aneesa , Satyender Apuri , Chandana G. , Bantu Rajaskaker
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nickel‐Catalyzed Direct Arylation of Azoles with Aryl Bromides.
Authors: Hachiya Hitoshi , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1,2,5‐Thiadiazole‐3(2H)‐thiones and 1,2,5‐Thiadiazol‐3(2H)‐ones from 1,2,3‐Dithiazoles.
Authors: Konstantinova Lidia S. , Bol'shakov Oleg A. , Obruchnikova Natalia V. , Golova Svetlana P. , Nelyubina Yulia V. , Lyssenko Konstantin A. , Rakitin Oleg A.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fused Pyran and Arylbis(4‐hydroxy‐6‐methyl‐2‐oxo‐2H‐pyran‐3‐yl)methane in Ionic Liquid.
Authors: Fan Xue Sen , Qu Ying Ying , Zhang Xin Ying , Wang Xia , Wang Jian Ji
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Pyrone Carbaldehydes, Pyrone Sulfonium Ylides and Related Epoxides.
Authors: Shahrisa Aziz , Saraei Mahnaz
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sc(OTf)3‐Catalyzed Conjugate Allylation of Alkylidene Meldrum′s Acids.
Authors: Dumas Aaron M. , Fillion Eric
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Building Molecular Complexity via Tandem Ru‐Catalyzed Isomerization/C—H Activation.
Authors: Bartoszewicz Agnieszka , Martin‐Matutue Belen
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ganoderic Acid DM: Antiandrogenic Osteoclastogenesis Inhibitor.
Authors: Liu Jie , Shiono Jun , Shimizu Kuniyoshi , Kukita Akiko , Kukita Toshio , Kondo Ryuichiro
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nagelamides Q and R, Novel Dimeric Bromopyrrole Alkaloids from Sponges Agelas sp.
Authors: Araki Atsushi , Kubota Takaaki , Aoyama Kazuki , Mikami Yuzuru , Fromont Jane , Kobayahsi Jun'ichi
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Haliclonin A, a New Macrocyclic Diamide from the Sponge Haliclona sp.
Authors: Jang Kyoung Hwa , Kang Gyoung Won , Jeon Ju‐eun , Lim Chaemin , Lee Hyi‐Seung , Sim Chung J. , Oh Ki‐Bong , Shin Jongheon
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.).
Authors: Suzuki Akiko , Shirota Osamu , Mori Kanami , Sekita Setsuko , Fuchino Hiroyuki , Takano Akihito , Kuroyanagi Masanori
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hypervalent Halogans and Their Reactions in Organic Synthesis
Authors: Ochiai Masahito
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions and Uses of Artificial Ketoses.
Authors: Yamanoi Takashi , Matsuda Sho
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Methyl‐2,5‐dihydro‐1‐benzoxepins and 3‐Methyl‐2,5‐dihydrooxepins.
Authors: Yamaguchi Seiji
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalysts Based on Amino Acids for Asymmetric Reactions in Water
Authors: Paradowska Joanna , Stodulski Maciej , Mlynarski Jacek
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Self‐Organized Porphyrinic Materials
Authors: Drain Charles Michael , Varotto Alessandro , Radivojevic Ivana
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Functional Nucleic Acid Sensors
Authors: Liu Juewen , Cao Zehui , Lu Yi
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peptidomimetics: Fmoc Solid‐Phase Pseudopeptide Synthesis
Authors: Cudic Predrag , Stawikowski Maciej
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peculiarities of Chemical Properties of Imidazole‐Derived and Other Types of Cyclic Nitrones and Their Use in Organic Synthesis
Authors: Grigor'ev Igor A.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Synthesis — A New Technology in Drug Discovery
Authors: Santagada V. , Frecentese F. , Perissutti E. , Fiorino F. , Severino B. , Caliendo G.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Niobium as Promoting Agent for Selective Oxidation Reactions
Authors: Guerrero‐Perez M. Olga , Banares Miguel A.
Published: August 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structure‐Based Design, Synthesis, and Evaluation of 2′‐(2‐Hydroxyethyl)‐2′‐deoxyadenosine and the 5′‐Diphosphate Derivative as Ribonucleotide Reductase Inhibitors
Authors: Sun Dianqing , Xu Hai , Wijerathna Sanath R. , Dealwis Chris , Lee Richard E.
Published: August 2009

Analysis of the recently solved X‐ray crystal structures of Saccharomyces cerevisiae ribonucleotide reductase I (ScRnr1) in complex with effectors and substrates led to the discovery of a conserved water molecule located at the active site that interacted with the 2′‐hydroxy group of the nucleoside ribose. In this study 2′‐(2‐hydroxyethyl)‐2′‐deoxyadenosine 1 and the 5′‐diphosphate derivative 2 were designed and synthesized to see if the conserved water molecule could be displaced by a hydroxymethylene group, to generate novel RNR inhibitors as potential antitumor agents. Herein we report the synthesis of analogues 1 and 2, and the co‐crystal structure of adenosine diphosphate analogue 2 bound to ScRnr1, which shows the conserved water molecule is displaced as hypothesized.
Evaluating the cost‐effectiveness of cancer patient navigation programs: Conceptual and practical issues
Authors: Ramsey Scott , Whitley Elizabeth , Mears Victoria Warren , McKoy June M. , Everhart Rachel M. , Caswell Robert J. , Fiscella Kevin , Hurd Thelma C. , Battaglia Tracy , Mandelblatt Jeanne ,   for the Patient Navigation Research Program Group
Published: August 2009

Patient navigators—individuals who assist patients through the healthcare system to improve access to and understanding of their health and healthcare—are increasingly used for underserved individuals at risk for or with cancer. Navigation programs can improve access, but it is unclear whether they improve the efficiency and efficacy of cancer diagnostic and therapeutic services at a reasonable cost, such that they would be considered cost‐effective. In the current study, the authors outline a conceptual model for evaluating the cost‐effectiveness of cancer navigation programs. They describe how this model is being applied to the Patient Navigation Research Program, a multicenter study supported by the National Cancer Institute's Center to Reduce Cancer Health Disparities. The Patient Navigation Research Program is testing navigation interventions that aim to reduce time to delivery of quality cancer care (noncancer resolution or cancer diagnosis and treatment) after identification of a screening abnormality. Examples of challenges to evaluating cost‐effectiveness of navigation programs include the heterogeneity of navigation programs, the sometimes distant relation between navigation programs and outcome of interest (eg, improving access to prompt diagnostic resolution and life‐years gained), and accounting for factors in underserved populations that may influence both access to services and outcomes. In this article, the authors discuss several strategies for addressing these barriers. Evaluating the costs and impact of navigation will require some novel methods, but will be critical in recommendations concerning dissemination of navigation programs. Cancer 2009. © 2009 American Cancer Society.
The higher the decrease in the standardized uptake value of positron emission tomography after chemoradiation, the better the survival of patients with gastroesophageal adenocarcinoma
Authors: Javeri Heta , Xiao Lianchun , Rohren Eric , Lee Jeffrey H. , Liao Zhongxing , Hofstetter Wayne , Maru Dipen , Bhutani Manoop S. , Swisher Stephen G. , Macapinlac Homer , Wang Xuemei , Ajani Jaffer A.
Published: August 2009

BACKGROUND:

Postchemoradiation percentage decrease in standardized uptake value (SUV) of positron emission tomography (PET) from baseline correlates with overall survival (OS) and pathologic response. Analyses of dichotomized data are commonly reported. The authors analyzed percentage SUV decrease as both dichotomized and continuous variables.

METHODS:

The authors assessed 151 consecutive patients with gastroesophageal adenocarcinoma who had chemoradiation and surgery. Baseline and postchemoradiation PET/computed tomography imaging was performed. The log‐rank test and Cox proportional hazards models were used to associate percentage SUV changes and OS, and logistic regression models were used to detect the association between percentage SUV changes and pathologic response.

RESULTS:

A >52% SUV decrease (dichotomized analysis) was associated with a longer OS (log‐rank test,P= .023). The univariate Cox proportional hazards model indicated that greater percentage SUV decrease (as a continuous variable) was associated with a lower risk of death (hazard ratio [HR], 0.99;P= .01). Pathologic response (≤50% residual cancer) was associated with longer OS (P= .003). Patients with chemoradiation resistance (>50% residual cancer) tended to have a higher risk of death than those with chemoradiation sensitivity (0‐50% residual cancer; HR, 2.12;P= .099). In the multivariate model, the percentage SUV decrease (as a continuous variable) was the only prognosticator of OS (P= .01). The percentage SUV decrease was nonsignificantly associated with pathologic complete response (univariate odds ratio [OR], 1.01;P= .06 and multivariate OR, 1.03;P= .07).

CONCLUSIONS:

The greater the decline in SUV after chemoradiation, the longer is the OS of gastroesophageal adenocarcinoma patients. The percentage SUV decrease as a continuous variable is a better prognosticator of OS than its dichotomized assessments. Cancer 2009. © 2009 American Cancer Society.
Percutaneous computed tomography‐guided lung biopsy and pleural dissemination
Authors: Sano Yoshifumi , Date Hiroshi , Toyooka Shinichi , Oto Takahiro , Yamane Masaomi , Hiraki Takao , Gobara Hideo , Mimura Hidefumi , Kanazawa Susumu
Published: August 2009

BACKGROUND:

Percutaneous computed tomography (CT)‐guided needle biopsy remains one of the most important diagnostic tools in the management of lung nodules; however, it carries a risk of intrapleural dissemination of cancer cells.

METHODS:

CT‐guided lung biopsy was performed before surgery in 171 (34.8%) of 491 patients. A coaxial biopsy system was used that comprised a 19‐gauge introducer needle and a 20‐gauge core biopsy needle. A total of 412 (83.9%) of the 491 patients underwent intraoperative pleural lavage cytology just after thoracotomy. Intraoperative pleural lavage cytology was performed immediately after opening the thorax, after the pleural cavity was gently washed with 50 mL of saline.

RESULTS:

No patients had implantation of cancer cells in the chest wall after a median follow‐up of 20.2 months. Intraoperative pleural lavage cytology results were positive for 5 (2.9%) of the 171 patients who underwent CT‐guided biopsy before surgery, in contrast to 13 (5.4%) of the 241 patients who did not undergo biopsy before surgery. The difference between the biopsy and nonbiopsy groups was not statistically significant. When the analysis was limited to patients with stage IA disease, intraoperative pleural lavage cytology results were positive for 1 (0.8%) of the 128 patients who underwent CT‐guided biopsy, in contrast to 3 (2.7%) of the 110 patients who did not undergo biopsy. This difference was also not statistically significant.

CONCLUSIONS:

No significant association was observed between percutaneous CT‐guided lung biopsy and intraoperative pleural lavage cytology results, even in patients with stage IA disease. Percutaneous CT‐guided lung biopsy with a coaxial needle does not seem to cause pleural dissemination. Cancer 2009. © 2009 American Cancer Society.
Localization of relaxin‐3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate
Authors: Ma Sherie , Sang Qian , Lanciego José L. , Gundlach Andrew L.
Published: August 2009

Relaxin‐3 (RLN3) is a highly conserved, ancestral member of the insulin/relaxin peptide family. RLN3 mRNA is highly expressed in rat, mouse, and human brain and molecular genetic and pharmacological studies suggest that RLN3 is the cognate ligand for the relaxin family peptide‐3 receptor (RXFP3). The distribution of RLN3/RXFP3 networks has been determined in rat and mouse brain, but not in higher species. In this study we describe the distribution of RLN3 neurons in the brain of macaque (Macaca fascicularis) using in situ hybridization histochemistry and immunohistochemistry. RLN3 mRNA and high levels of RLN3‐like immunoreactivity (‐LI) were observed in neurons within a ventromedial region of the central gray of the pons and medulla that appears to represent the primate analog of the nucleus incertus (NI) described in lower species. Nerve fibers and terminals containing RLN3‐LI were observed throughout brain regions identical to those known to receive afferents from the NI in the rat, including the septum, hippocampus, entorhinal cortex, lateral, dorsomedial and ventromedial hypothalamus, supramammillary and interpeduncular nuclei, anterodorsal, paraventricular and reuniens thalamic nuclei, lateral habenula, central gray, and dorsal raphe, solitary tract, and ambiguus nuclei. Experimental studies in the rat strongly implicate a role of this neuropeptide‐receptor system in arousal, feeding, and metabolism, learning and memory, and central responses to psychological stressors. These new anatomical findings support the proposition that the RLN3 system is similarly involved in the integration and modulation of behavioral activation and arousal and responses to stress in nonhuman primates and humans. J. Comp. Neurol. 517:856–872, 2009. © 2009 Wiley‐Liss, Inc.
Expression of the diabetes‐associated gene TCF7L2 in adult mouse brain
Authors: Lee Syann , Lee Charlotte E. , Elias Carol F. , Elmquist Joel K.
Published: August 2009

Polymorphisms of the gene TCF7L2 (transcription factor 7‐like 2) are strongly associated with the development and progression of type 2 diabetes. TCF7L2 is important in the development of peripheral organs such as adipocytes, pancreas, and the intestine. However, very little is known about its expression elsewhere. In this study we used in situ hybridization histochemistry to show that TCF7L2 has a unique expression pattern in the mouse brain. TCF7L2 is expressed in two distinct populations. First, it is highly expressed in thalamic and tectal structures. Additionally, TCF7L2 mRNA is expressed at moderate to low levels in specific cells of the hypothalamus, preoptic nucleus, and circumventricular organs. Collectively, these patterns of expression suggest that TCF7L2 has distinct functions within the brain, with a general role in the development and maintenance of thalamic and midbrain neurons, and then a distinct role in autonomic homeostasis. J. Comp. Neurol. 517:925–939, 2009. © 2009 Wiley‐Liss, Inc.
Magnetic Alignment in Solid State and Temperature Hysteresis in Aqueous Tetrahydrofuran Solution for Tetrathiafulvaleno[18]annulenes
Authors: Enozawa Hideo , Hasegawa Masashi , Isomura Eigo , Nishinaga Tohru , Kato Tadashi , Yamato Masafumi , Kimura Tsunehisa , Iyoda Masahiko
Published: August 2009

Tris(tetrathiafulvaleno)dodecadehydro[18]annulene‐hexaesters have a multi‐functionality that is very sensitive to small differences in the ester side‐chain. Self‐aggregation of the [18]annulenes in amphiphilic media such as THF–H2O (v/v, 1:1) either produce a fibrous structure or result in temperature hysteresis of the color and 1H NMR signals. This temperature hysteresis in solution is due to both strong self‐aggregation behavior and unique cluster formation in a binary solution of THF and water.
Polarized expression of integrin β1 in diencephalic roof plate during chick development, a possible receptor for SCO‐spondin
Authors: Caprile Teresa , Osorio Germán , Henríquez Juan Pablo , Montecinos Hernán
Published: August 2009

The roof plate of the caudal diencephalon is formed by the posterior commissure (PC) and the underlying secretory ependyma, the subcommissural organ (SCO). The SCO is composed by radial glial cells bearing processes that cross the PC and attach to the meningeal basement membrane. Since early development, the SCO synthesizes SCO‐spondin, a glycoprotein that shares similarities to axonal guidance proteins. In vitro, SCO‐spondin promotes neuritic outgrowth through a mechanism mediated by integrin β1. However, the secretion of SCO‐spondin toward the extracellular matrix that surrounds the PC axons and the expression of integrins throughout PC development have not been addressed. Here we provide immunohistochemical evidence to suggest that during chick development SCO cells secrete SCO‐spondin through their basal domain, where it is deposited into the extracellular matrix in close contact with axons of the PC that express integrin β1. Our results suggest that SCO‐spondin has a role in the development of the PC through its interaction with integrin β1. Developmental Dynamics 238:2494–2504, 2009. © 2009 Wiley‐Liss, Inc.
Ring A Modified Novel Triterpenoids from Dysoxylum hainanense
Authors: He Xiu‐Feng , Wang Xiao‐Ning , Yin Sheng , Dong Lei , Yue Jian‐Min
Published: August 2009

Six ring A modified novel triterpenoids, dysoxyhainic acids A–E (1–3, 5, and 6) and dysoxyhainol (4), were isolated from the twigs and leaves of Dysoxylum hainanense. Compounds 1–4 are a group of triterpenoids featuring a contracted five‐membered ring A. Dysoxyhainic acid A (1) possessed an unprecedented 2‐nor‐1,3‐cyclotirucallane skeleton, whereas 5 and 6 possessed a rare six‐membered δ‐lactone formed between C‐2 and C‐11. The structures of 1–6 were established by extensive spectroscopic analysis, and that of 1 was confirmed by single‐crystal X‐ray diffraction. A hypothetical biosynthetic pathway for compound 1 was also proposed. All the compounds were tested on antimicrobial assays, and compounds 2 and 3 exhibited moderate antibacterial activity against Gram‐positive bacteria. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Electrochemical Detection of Hydrazine Based on Electrospun Palladium Nanoparticle/Carbon Nanofibers
Authors: Zhang Haijiang , Huang Jianshe , Hou Haoqing , You Tianyan
Published: August 2009

In this work, we developed an electrochemical method for the detection of hydrazine based on palladium nanoparticle/carbon nanofibers (Pd/CNFs). Pd/CNFs were prepared by electrospinning technique and subsequent thermal treatments. The electrocatalytic behaviors of Pd/CNFs modified glassy carbon electrode (Pd/CNF‐GCE) for hydrazine oxidation were evaluated by cyclic voltammetry (CV), an obvious and well‐defined oxidation peak appeared at −0.32 V (vs. Ag/AgCl). The mechanism of the oxidation of hydrazine at Pd/CNF‐GCE was also studied, which demonstrated an irreversible diffusion‐controlled electrode process and a four‐electron transfer involved in the overall reaction. Furthermore, the wide linear range, low detection limit, good reproducibility and excellent storage stability were obtained utilizing differential pulse voltammetry (DPV).