bluuebunny/crossref_metadata_2025 huggingface dataset:
Вольтамперометрическое определение дифенгидрамина гидрохлорида в твердой дозированной и жидкой формах
Authors: Турусова Елена В. , Насакин Олег Евгеньевич
Published: December 2022

Разработана методика ускоренного определения дифенгидрамина гидрохлорида (димедрол, DPH) в жидкой и твердой дозированной формах, основанная на титровании аналитической формы раствором фотогенерированного йода, полученного в результате облучения вспомогательного раствора, содержащего йодид калия, уранин, при pH 6,0. Так как содержание титранта в растворе контролировалось вольтамперометрическим методом (амперометрическое титрование с двумя поляризованными электродами), стабилизация тока в цепи амперометрической установки свидетельствовала о полноте протекания реакции, а, следовательно, позволяла регламентировать содержание DPH в лекарственной форме (ЛФ). Дальнейшее облучение раствора и измерение времени генерации, необходимого для восполнения убыли титранта, также позволяло регламентировать содержание DPH в ЛФ. Методика апробирована на твердой дозированной форме и стерильных растворах DPH, предназначенных для внутримышечного и внутривенного введения. Установлено незначительное влияние стабилизаторов (соляной кислоты, лактозы моногидрата), присутствующих в ЛФ, на фотогенерацию титранта. Линейная зависимость аналитического сигнала от концентрации DPH наблюдается в интервале 0,1 – 20,0 мг для препарата «Димедрол, таблетки 50 мг». Рассчитанный предел обнаружения (ПО) и количественного определения (ПКО) для данного препарата составил (1,26; 0,108) мг и (0,382; 0,329) мг по изменению силы тока и времени генерации, соответственно. Разработанная фотохимическая методика определения соответствует требованиям, изложенным в руководстве по валидации биоаналитических методов, проста в исполнении, не требует дорогостоящего оборудования, а, следовательно, может быть рекомендована для рутинного контроля показателей его качества в условиях любой контрольно-аналитической лаборатории.
Разработка и валидация методики количественного определения рекомбинантного гетеродимерного белка RPH-104 в сыворотке крови как инструмента персонализации фармакотерапии
Authors: Колганова М. А. , Мельник Е. В. , Фишер Е. Н. , Гегечкори Владимир Ираклиевич , Замятнин А. А. , Неймышева Д. О. , Горпинченко Н. В. , Салтыкова О. В. , Шохин И. Е. , Раменская Г. В.
Published: December 2022

Разработана методика количественного определения инновационного рекомбинантного гетеродимерного белка RPH-104 в сыворотке крови человека методом иммуноферментного анализа (ИФА). Проведена валидация методики по показателям минимально необходимое разведение (MRD); селективность; калибровочная кривая и чувствительность; правильность и прецизионность (внутри цикла, между циклами); линейность разведения; специфичность; стабильность. MRD методики составило 1:100, чувствительность методики с учетом MRD — 10 нг/мл. Валидированная методика может быть рекомендована для проведения количественного определения RPH-104 в сыворотке крови пациентов с целью персонализации фармакотерапии и осуществления контроля за эффективностью проводимого лечения.
Macroeconomics and the Construction Sector: Evidence from Portugal
Authors: Correia Leonida , Ribeiro Maria João
Published: December 2022

Construction activity is considered one of the primary indicators of a country’s global economic evolution. This article aims to study the cyclical fluctuations of construction production and its relationship with the aggregate business cycles in Portugal over the last six decades. We started by analysing the evolution of an indicator set inherent to the functioning of the construction sector. Then, we extracted the construction output cycles and examined their association with the Portuguese business cycles since the 1960s, focusing on crisis periods. The results demonstrate that the construction sector contributes significantly to the Portuguese economy and the cyclical construction activity fluctuations correlate strongly with the aggregate fluctuations, albeit with greater instability. Finally, we discuss the current problems the construction sector faces and the COVID-19 pandemic effects. Keywords: construction sector, business cycles, volatility, synchronisation, crisis
Defending Against Copycat Packaging: The Role of Design from a Consumer’s Perspective
Authors: Oguz Ezgi , Marsden Jamie
Published: December 2022

Copycat packaging involves a type of imitation strategy in which the appearance of a market leader’s packaging design is simulated by a low-cost alternative. Previous literature has focused on reactive strategies against copycat packaging, primarily involving litigation and packaging design changes; however, very little attention has been assigned to the role of packaging design as a proactive strategy for mitigating against copycat packaging. To address this issue, this study examined the role of design in mitigating copycat packaging from a consumers’ perspective. We conducted an exploratory study of 37 semi-structured interviews to understand how consumers respond to the design components on visually similar packaging across a range of FMCG products. We found that packaging design cues have the greatest impact on purchasing decisions in cases where consumers have no familiarity with a brand, but less influence when consumers are already familiar with a brand. Consumers rank the importance of packaging design features differently depending on the product category. For high-cost items, consumers rank structural design as the most important feature, whereas colour is considered the most important for low-cost products. We end the paper by discussing the implications for brand managers and outline strategies for minimising the occurrence of copycat packaging. Keywords: copycat, packaging design, similarity, packaging strategy, consumer evaluation
„Wo er vorbei dir glänzt“
Authors: Menninghaus Winfried
Published: December 2022

This study focuses – by way of a close reading – on (1) the multiple subtleties in the poetic diction and word morphology of Hölderlin‘s ode „Heidelberg“, (2) its metonymic macro-structure, (3) the oscillations between an aesthetics of the lovely („lieblich“) and the sublime, (4) the instances of blissful self-mirroring that depart from Narcissus‘ unhappy fate, and (5) the explicit poetics of the „image“ („Bild“) in this ode. A special emphasis is placed on Hölderlin’s creation of a series of novel German words that combine two words into new compounds.
Etnobotánica de Acca sellowiana (Myrtaceae): una especie de uso múltiple de Misiones, Argentina
Authors: Nuñez Marcos , Keller Héctor , Pirondo Analía
Published: December 2022

Se dan a conocer resultados de una investigación sobre el vínculo entre los habitantes de Campo Viera, Misiones, Argentina, con la especie Acca sellowiana (O. Berg) Burret (Myrtaceae). Para ello se utilizaron metodologías de la etnobotánica cuali y cuantitativas: entrevistas-semiestructuradas, observación directa, y uso de estímulos visuales. Además se realizó un ranking de puntuación simple a niños de edad escolar, de una escuela rural ubicada en el área donde se encuentra la especie evaluada. Por último, se aplicaron los índices Valor de Diversidad Informante (VDI) y Valor de Diversidad de Uso (VDU). Los resultados demostraron la existencia de un vínculo entre las poblaciones locales y A. sellowiana, el cual no solo responde en términos utilitarios, sino también del tipo afectivo. Se distinguieron 4 categorías de uso principales: alimenticia, medicinal, combustible y ornamental, siendo la alimenticia la más mencionada (69%) a partir del consumo de frutos in situ y pétalos para la preparación de dulces y postres. Se destacó el conocimiento por parte de niños en edad escolar de la especie estudiada. Por último, se concluye que la presencia de la especie en la zona, y sus múltiples usos, hacen que se comporte como un recurso importante con potencial para generar alternativas de desarrollo local.
Análisis de la Revista Geográfica Digital desde las Ciencias de la Información. Miradas sobre la Difusión de Conocimiento como Proceso Inherente a la Evaluación de la Ciencia
Authors: Lebus Emilas
Published: December 2022

Este artículo aborda la evolución de la revista Geográfica Digital, editada por el Instituto de Geografía de la Universidad Nacional del Nordeste, Argentina. El propósito es analizar su línea editorial, el perfil de sus publicaciones y tipo de trabajos que admite, así como el estatus de la revista a partir de las indexaciones alcanzadas hasta el momento, considerando el período reciente de los últimos diez años.

Este artículo permite comprender su estado de situación, como publicación científica periódica, la tipología de revista, sus alcances y proyección futura.
El abordaje proyecta distintas miradas desde las Ciencias de la Información, mediante métodos cualitativos de evaluación de los procesos de difusión científica. Los resultados muestran una situación promisoria, por la diversidad de trabajos y autores, y su constante jerarquización entre las revistas de la disciplina y de Ciencias Sociales y Humanas, aunque su principal desafío consiste en superar los circuitos endogámicos de publicación.
Роль вітаміну D у розвитку, перебігу та лікуванні артеріальної гіпертензії
Authors: Кондратюк В. Є. , Тарасюк А. П.
Published: December 2022

The literature review considers the new universal molecule empagliflozin, which managed to change the glucose‑centric approach in endocrinology to an organoprotective one. The results of the pivotal clinical trials conducted with empagliflozin (EMPA‑REG‑OUTCOME, EMPEROR‑REDUCED, EMPEROR‑PRESERVED and EMPULSE) strongly support the ability of empagliflozin to reduce rates of cardiovascular death or hospitalization for heart failure and to slow down the progression of chronic kidney disease. Among the confirmed and potentially favorable metabolic consequences of empagliflozin administration, the following should be emphasized: a selective antihyperglycemic effect only in conditions of hyperglycemia/glucosuria, which does not depend either on insulin production or sensitivity of peripheral tissues to insulin but is limited only by the glomerular filtration rate. This effect allows avoiding hypoglycemia even in patients without diabetes. The drug is one of the most durable among oral hypoglycemic agents and allows to maintain the achieved HbA1c values for 6 — 8 years, delaying the initiation of insulin therapy in patients with type 2 diabetes mellitus. Empagliflozin was superior to placebo in preventing death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke in patients with type 2 diabetes mellitus. This effect resulted from the significant reduction in the risk of cardiovascular mortality without significant changes in nonfatal myocardial infarction or nonfatal stroke. Combination with other oral and injectable hypoglycemic drugs is possible. In case of combination with sulfonylurea drugs or insulin, the dose of the latter needs to be adjusted in the direction of its decrease. Weight loss of up to 2 — 3 kg against the background of empagliflozin is an expected phenomenon that can modify blood pressure indicators and insulin resistance. Empagliflozin has the ability to reduce steatosis and improve liver fibrosis scores in patients with NAFLD without type 2 diabetes mellitus.
Tuberculosis in Ukraine during the COVID-­19 pandemic
Authors: Valetskyi Yu.M. , Valetska R.O. , Hryshchuk L.A. , Zahorulko V.M. , Patrakeieva L.Ya. , Pakharchuk S.M.
Published: December 2022

Objective — to study the situation with tuberculosis in Ukraine in 2020—2021 compared to 2019.

Materials and methods. Searched and statistically analyzed data from official statistical reports and analytical collections on tuberculosis for 2019—2021 in Ukraine.

Results and discussion. The COVID-19 epidemic, to eliminate which the main material and human resources in health care were directed, aggravated the epidemiological situation with tuberculosis in Ukraine; there was a reduction in anti-tuberculosis activities, human resources and infrastructure of anti-tuberculosis institutions. This has led to a decrease in TB incidence, prevalence and mortality, while in other parts of the world, TB incidence and mortality rates and the effectiveness of treatment have increased significantly.

Conclusions. During the COVID-19 pandemic, the majority of health resources have been devoted to fighting it. Anti-tuberculosis measures were secondary and were being phased out. This led to a decrease in statistical indicators of the incidence of all clinical forms of tuberculosis and mortality from it, including multi-resistant, and its relapses, as well as co-infection — tuberculosis/HIV/AIDS. The incidence of tuberculosis among medical workers decreased. The prevalence of all forms of active tuberculosis among Ukrainians had the same trend as the incidence.
Surgical reinnervation of the dentate anterior muscle in long-term idiopathic neuropathy of the long thoracic nerve: a case report
Authors: Gatskiy O. O. , Tretyak I. B. , Tsymbaliuk V. I. , Tsymbaliuk Y. V. , Tretiakova A. I. , Jiang Hao
Published: December 2022

Cases of pterygoid deviation (deviation) of the scapula are associated with dysfunction of the muscles of the primary stabilizers of its superior medial and inferior medial edges. One of the factors of KDL is idiopathic neuropathy of the long thoracic nerve (LPN). The ineffectiveness of therapeutic methods of treatment of KDL can be compensated by the use of surgical correction methods. Carrying out decompression of the DGN makes it possible to achieve partial regression in 87 % of patients and complete regression of the deficiency — in 62 % in terms of up to 6 months. The method of selective targeted reinnervation of nerve structures — neurotization is devoid of a number of disadvantages of traditional surgical methods, makes it possible to eliminate the influence of the time factor on the complex process of denervation/reinnervation and ensures the predictability of the outcome.
A 27‑year‑old male attended the department with pain in the right shoulder joint, limitation of flexion in the right shoulder joint to 130°, external rotation of the shoulder to 75°, abduction of the right shoulder to 150°. The function of the right deltoid muscle is within the normal range (M5 according to the British MRC scale), KDL at rest (static) and during movements (dynamic). The duration of the disease is about 7 months. Electroneuromyography (EMG) revealed a violation of the conduction of motor fibers of the DGN and a long‑standing denervation process without signs of reinnervation in the dentate anterior muscle (DAM). The patient underwent neurotization of the DGN with the anterior portion of the thoraco‑spinal nerve (PP GSN) according to the method of C. B. Novak and S. E. Mackinnon. A follow‑up examination of the patient was carried out 9, 15 and 19 months after surgical reinnervation. In addition to clinical neurological examination, ENMG was performed. The pain in the right shoulder girdle regressed completely. Full regression of the KDL at rest (static) and partial during movements (dynamic) of the right upper limb was noted. The ENMG data confirmed the reinnervation of the PZM. The use of a more aggressive surgical approach — neurotization made it possible to bring the axons with preserved function (PP GSN) closer to the end motor plates of the non‑functioning nerve (DGN), which contributed to achieving a positive functional result — the restoration of PZM. Selective use of PP GSN made it possible to preserve the functionality of the latissimus dorsi muscle at the expense of preserving the posterior portion of the nerve donor.
What do Consumers really want? Online Vs Offline Shopping for Fashion Products
Authors: Sisca Sisca , Wijaya Andy , Grace Ernest , Putri Debi Eka , Sidabutar Novelyne
Published: December 2022

Digitalization has changed human behavior in carrying out various activities, one of which is consumer behavior in shopping. Nowadays, many consumers often make purchases of products online. However, certain products actually require a more in-depth product evaluation before consumers decide to buy the product, which can only be done by shopping offline, one of them is fashion products. This research is conducted to identify the factors that motivate consumers in Indonesia to shop online or offline and determine whether there are differences between these motivating factors based on the demographic characteristics of consumers. Data collection is carried out by distributing questionnaires online through whatsapp and telegram groups during June-July 2021, which resulted in 162 responses. Chi-Square, Mann-Whitney, and Kruskal-Wallis tests are used to test the hypothesis. The results prove that the relationship between the motivating factors to shop offline and preferred shopping method with the consumer demographic characteristics, most of them show insignificant results. Different results are shown in the relationship between the motivating factors to shop online with the consumer demographic characteristics, which most of them show significant results (age group, marital status and education level). Furthermore, research data also shows that more than half of the respondents still prefer to shop for fashion products offline rather than online although in the Covid-19 pandemic situation because they want to evaluate the product physically. Suggestions for future researchs to adopt a more representative sampling technique to replicate this research and adopt different product categories to explore how consumers behave in other product categories. This research provides a deeper understanding of consumer shopping behavior for fashion products both online and offline as well as provides an overview that there is still a future for offline fashion product stores to survive in competition with online stores by improving themselves to deal with consumer purchases in this new normal era.
An Overview of The Psychological Well-Being Of Entrepreneurs In Riau Province
Authors: Anastasia Sri Maryatmi , Hardiyanto Yudi
Published: December 2022

At this time when competition in the economy is increasing and the COVID-19 pandemic situation, not all entrepreneurs in entrepreneurship are able to reach the level of psychological well-being because no one can guarantee whether the business will be successful or not.

This study aims to give the description of psychological well-being on entrepreneurs in Riau Province during the COVID-19 pandemic and to determine the differences on psychological well-being among entrepreneurs in Riau Province base on the demographic data of entrepreneurs.

The method used to collect the data of psychological well-being and a demographic scale is distribute the questioners to 130 entrepreneurs in Riau Province. The sampling technique used is cluster random sampling. The analytical method used is descriptive analysis and different test using program SPSS 23.0.

Based on the analysis test, it was found that the level of psychological well-being in entrepreneurs in Riau Province was classified as moderate. The dimensions of self-acceptance, positive relationships with others, autonomy, purpose in life and environmental mastery in entrepreneurship in Riau Province are moderate, while the dimensions of personal growth in entrepreneurship in Riau Province are high. The results also show that the hypothesis is rejected with no significant difference in the psychological well- being of Riau Province entrepreneurs based on the demographic factors tested.
Daha Sürdürülebilir Tarımsal Sistemlere Geçişte Tabandan Yenilikçilik: Seferihisar Doğa Okulu ve Karaburun Zeytin Okulu Örneği
Authors: YAZAR YILDIZTEKİN Merve , EROL Demet
Published: December 2022

Günümüzde tarımsal sistemlerin karşı karşıya kaldığı zorluklarla mücadele için sürdürülebilir bir tarımsal sistem inşa edilmesi ve bu amaçla yeniliklerin desteklenerek sürekli hale getirilmesi gerekmektedir. Sosyal hareketler yeniliğin gerçekleşmesi için önemli kaynaklar olabilmekte; çevre, sağlık, sosyal adalet ve etik gibi konuları toplumun gündemine taşıyarak geniş kitleler üzerinde baskı yaratabilmektedir. Bu baskı içerisinde sivil toplumun rolü daha sürdürülebilir pratiklere doğru gerçekleşen geçişlerde henüz yeterince yer bulamamakla birlikte önemli potansiyeller taşımaktadır ve son yıllarda sivil toplum alanında deneyimlenen sosyal yenilikler için “tabandan yenilikler” kavramı geliştirilmiştir. Çalışmada İzmir’in Yarımada olarak adlandırılan bölümünde yer alan ve kaynağını sivil toplum yapılanmalarından alan Seferihisar Doğa Okulu ve Karaburun Zeytin Okulu’nun örgütsel rutinleri ve ağ ilişkileri ile nasıl bağlantılar kurduğu ve politika düzeyindeki aktörler ve geniş kitleler üzerinde baskı yaratmak amacıyla ne tür stratejiler izlediği araştırılmaktadır. Çalışma ile bir coğrafi ölçekte bulgulara dayanarak daha sürdürülebilir pratiklere geçişte sivil toplumun üstlenebileceği rollerin neler olabileceğine ilişkin bir kavramsallaştırma yapılması ile sürdürülebilirlik geçişlerine ilişkin verilen yazına katkı sağlanmaktadır.
Yeniden İşlevlendirilen Kırşehir Konaklarının Sosyokültürel Sürdürülebilirlik Kapsamında İrdelenmesi
Authors: YURDUGÜZEL Olcay Türkan
Published: December 2022

Geçmişin kültürel ayak izinin geleceğe aktarılması, sosyal ve kültürel toplumsal birikimin sürekliliğinin sağlanması tarihi yapıların korunması ile mümkün olmaktadır. Bu yapıların korunarak mirasın geleceğe aktarılması ile sosyokültürel sürdürülebilirliğin devamlılığı, toplumda geçmiş kültür bilinci oluşturulması ve kentsel kimliğin korunması sağlanmış olur. Anıt eserlerinin Selçuklu Dönemine tarihlendiği Kırşehir kentinde 20. yy. başlarına tarihlenen konak yapıları yer almaktadır. Belli bir doku oluşturmayan konaklardan bazıları günümüzde özgününden farklı işlevlerle korunarak kullanılmaya devam etmektedir. Çalışmanın konusu olarak seçilen, özgün ya da özgünden farklı işlevle kullanılmaya devam eden konaklar farklı tarihlerde geçirdikleri koruma çalışmaları ile müze, kafe/restoran ve Ahilik Araştırma Merkezi olarak dönüştürülmüştür. Bu çalışma ile işlevsel olarak dönüştürülen konakların kent kimliğine, sosyokültürel devamlılığın sağlanmasına ve kullanıcıya sağladığı katkı, rastgele seçilen kullanıcı grubuna yapılan anket ile belirlenmeye çalışılmıştır. Anket sorularında kullanıcıların yapıları kullanma durum ve sıklıkları belirlenerek gerçekleştirilen işlevsel dönüşümün kullanıcı ve yapı arasındaki ilişkiye sağladığı katkı belirlenmeye çalışılmıştır. Bu kapsamda, günümüz kullanım koşullarına uygun işlevlerle dönüştürülen tarihi eser yapıların korunma ve yaşatılma düzeyinin arttığı belirlenmiştir. Kentin sosyokültürel değerlerinin devamını sağlamakta etkin olan yapıların sürdürülebilirliğinin işlevsel dönüşümle sağlanmış olması kentin kültürel ayak izinin kuşaklara aktarılmasında etkili önemli uygulamalardır.
Differential expression of SLC7A6 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published microarray data (3, 4). We found significant differential expression of SLC7A6, encoding solute carrier family 7 member 6, in the skeletal muscle of patients with ALS. SLC7A6 was also differentially expressed in primary motor neurons isolated from patients with ALS. SLC7A6 transcript was present at significantly higher levels in skeletal muscle from patients with ALS as compared to skeletal muscle from control individuals. These analyses will begin to define the transcriptional landscape of ALS.
Portofolio logika
Authors: febriana Fica
Published: December 2022

Himpunan juga terdiridari 3 macam yaitu,Himpunan kosong,Himpunan semesta dan Himpunan yg sama Diagram venn ,Terdapat rumus dasar dari diagram venn, yaitu:n(X 𝖴Y)=n(X)+n(Y)–n(X ∩ Y)n(X 𝖴 Y 𝖴 Z)=n(X)+n(Y)+n(Z) –n(X∩ Y)–n(Y∩ Z)–n(Z∩ X)+n(X∩ Y∩ Z)Keterangan :n(X) = Jumlah elemen pada himpunan X Relasi dari himpunan A ke himpunan B adalah aturan yang menghubungkan anggota- anggota himpunan A dengan anggotaanggota himpunan B Relasi antara dua himpunan X dan Y, dapat dinyatakan sebagai himpunan pasanganberurutan (x, y) dengan x anggota himpunan pertama (X) dan y anggota himpunan kedua(Y).
PENERAPAN NILAI NORMATIF, NILAI NOMINAL DAN NILAI SEMANTIK DALAM MENGATUR HAK DAN KEWAJIBAN WARGA NEGARA YANG DIATUR DALAM UUD 1945
Authors: VANIYA ISA FATHUL
Published: December 2022

Konsep HAM telah diterima di Indonesia, namun implementasinya belum sepenuhnya sesuai dengan yang dipraktekkan di negara-negara yang memiliki perlindungan HAM yang lebih maju. Penelitian ini menganalisis bagaimana nilai normatif, nilai nominal, dan nilai semantik yang diatur dalam UUD 1945 dapat membantu mengatur hak dan kewajiban warga negara di Indonesia. Hasil penelitian menunjukkan bahwa ketiga konsep ini dapat memberikan keseimbangan tatanan masyarakat dan memastikan bahwa hak dan kewajiban warga negara dipenuhi dengan baik untuk kepentingan masyarakat. Akibatnya, nilai normatif, nilai nominal dan nilai semantik sangat penting untuk mengatur hak dan kewajiban warga negara.
Portofolio Logika
Authors: Farid Arya Muhammad
Published: December 2022

Logika sebagai salah satu cabang ilmu filsafat yang dapat dipraktikkan dalam kehidupan sehari-hari. Dalam bidang filsafat sendiri, logika tidak dapat dipisahkan dalam proses mencari sesuatu kebenaran atau kesahihan.
Portofolio logika
Authors: Poli Elsiana
Published: December 2022

Logika adalah sebuah istilah yangberhubungan dengan pikiran manusia.Logika sebagai salah satu cabang ilmufilsafat yang dapat dipraktikkan dalamkehidupan sehari-hari. Dalam bidangfilsafat sendiri, logika tidak dapatdipisahkan dalam proses mencarisuatu kebenaran atau kesahihan.Logika bisa dikatakan sebagai logikascientia ataupun ilmu logika. Dilihatdari logika sebagai ilmu, logikamempelajari kebolehan manusiauntuk berpikir secara sejajar, teratur,dan tepat. Adapun objek materialyang dipakai ilmu logika adalahberpikiran sesuai nalar, sementaraobjek formal dari logika adalahpemikiran yang dipelajari dari aspekketepatannya.
Differential expression of HOXC8 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published and public data (3, 4). We found significant differential expression of HOXC8, encoding homeobox C8, in the skeletal muscle of patients with ALS. HOXC8 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. HOXC8 transcript was present at significantly lower levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS.
SIRS classification in the nomenclature of preeclampsia: Systemic Inflammatory Response Syndrome of Pregnancy (SIRS-P)
Authors: Sarohan Aziz Rodan
Published: December 2022

Due to the excess of etiological factors, preeclampsia has been called the disease of theories for ages. Preeclampsia has always been difficult to understand due to the multitude of etiological factors. Preeclampsia is a systemic inflammatory response of pregnancy accompanied by syncytiotrophoblast stress, endothelial damage, atherosclerosis, oxidative stress, uteroplacental ischemia, and hypertension, in which many etiological factors trigger and activate common inflammatory pathways. This disease, which is a kind of Systemic Inflammatory Response Syndrome (SIRS) in terms of molecular pathogenetic mechanisms, can also be defined as the systemic inflammatory response syndrome of pregnancy (SIRS-P). Likewise, in terms of molecular dynamics and clinical features, preeclampsia is compatible with a syndrome complex rather than a disease. Placental invasion (implantation) anomaly has been blamed the most for the pathogenetic disorder in preeclampsia. However, when we look at the whole picture, the main pathogenetic disorder common to all diseases that play a triggering role for preeclampsia is excessive inflammatory cytokine secretion. Preeclampsia mainly develops from the background of an inflammatory process. In these diseases, which have a common etiological origin, there is vascular endothelial damage, atherosclerosis, tissue ischemia, and finally, excessive release and activity of inflammatory cytokines such as IL1, IL6, TNFα, IFNg, and free oxygen radicals. Likewise, in preeclampsia, as in other inflammatory diseases, devastating systemic effects and feto-maternal organ damage occur as a result of excessive inflammatory cytokine release. While arterial pressure is low in inflammatory pathologies such as SIRS, Sepsis, and ARDS, hypertension is usually added to the clinical picture in pre-eclampsia. The reason why hypertension is added to the SIRS picture in preeclampsia is the compensatory activation of the maternal renin-angiotensin-aldosterone system and overactivity due to uteroplacental ischemia. In this study, the inflammatory molecular dynamics of preeclampsia are reviewed and the SIRS-P classification is brought to preeclampsia based on the systemic inflammatory pathogenetic mechanism. Defining preeclampsia as pregnancy-related or placenta-related SIRS is also terminologically appropriate and will change our perspective and approach to preeclampsia.Keywords: Preeclampsia, SIRS, SIRS-P, inflammation, uteroplacental ischemia, pregnancy, hypertension, autoimmunity, retinoid signaling, autoantibodies, anti-placental antibodies, IL6, TNFα
Portofolio logika
Authors: Ohoiwutun Kostantina
Published: December 2022

Logika adalah sebuah istilah yangberhubungan dengan pikiran manusia.Logika sebagai salah satu cabang ilmufilsafat yang dapat dipraktikkan dalamkehidupan sehari-hari. Dalam bidangfilsafat sendiri, logika tidak dapatdipisahkan dalam proses mencarisuatu kebenaran atau kesahihan.Logika bisa dikatakan sebagai logikascientia ataupun ilmu logika. Dilihatdari logika sebagai ilmu, logikamempelajari kebolehan manusiauntuk berpikir secara sejajar, teratur,dan tepat.
Portofolio logika Mawar Pada tau(C1C122027)
Authors: Padatau Mawar
Published: December 2022

Secara etimologi, Logika berasal dari perkataanYunani yaitu logike (kata sifat) dan logos (katabenda), yang berarti "pikiran atau perkataansebagai pemyataan dari pikiran, alasan atauuraian". Dengan demikian, logika merupakanpekerjaan akal pikiran manusia dalam bernalaruntuk menghasilkan kebenaran ataupenyimpulan yang benar. Sebagai ilmu, disebutlogica scientia yang berarti ilmu logika, namunsekarang ini hanya lazim disebut dengan logikasaja. Jadi, logika adalah suatu ilmu pengetahuantentang prinsip-prinsip dan norma-normapenyimpulan yang dipandang dari aspek yangbenar (sahih). Aristoteles, mengungkapkan"logika adalah ajaran mengenai berpikir secarailmiah membahas wujud pikiran itu sendiri danhukum yang mengendalikan pikiran". Logikasebagai Ilmu Pengetahuan Logika sebagai suatucabang ilmu pengetahuan dengan objekmaterialnya adalah berpikir atau bernalar atauproses penalaran.
Portofolio Logika
Authors: Widiyanti Arina
Published: December 2022

Secara bahasa logika diambil dari kata yunani kuno (logos) yaitu ilmu yang mempertimbangkan akal pikiran yang disampaikan lewat bahasa dan kata-kata.istilah logika ini diperkenalkan oleh seorang filsuf di abad 1 SM yang bernama cicero. Kala itu artinya seni berdebat. Seiring berjalannya waktu,diabad ketiga sesudah masehi,munculah tokoh Alexander Aphrodisias yang memperjuangkan “logika” sebagai pengukur kewarasan dalam berfikir.
Dewi sartika
Authors: B Rahmawati
Published: December 2022

Seperti telah kita ketahui bahwa matematika merupakan salah satu ilmu yang sangat bermanfaat dalam kehidupan sehari-hari. Salah satunya konsep dasar himpunan yang hampir mendasari seluruh cabang matematika. Himpunan sendiri berhubungan erat dengan keseharian kita, dengan belajar himpunan kita diharapkan mampu memahami dari materi himpunan itu sendiri yang mungkin bermanfaat dalam kehidupan kita. Dalam matematika, himpunan adalah segala koleksi benda-benda tertentu yang dianggap sebagai satu kesatuan. Walaupun hal ini merupakan ide yang sederhana, tidak salah jika himpunan merupakan salah satu konsep penting dan mendasar dalam matematika modern, dan karenanya, studi mengenai himpunan merupakan ide yang sederhana, tidak salah jika himpunan merupakan salah satu konsep penting dan mendasar dalam matematika modern, dan karenanya, studi mengenao himpunan sangatlah berguna.
Portofolio logika
Authors: Rahmiati
Published: December 2022

Logika adalah hasil pertimbangan dari akal pikiran manusia yang diutarakan melaluikata-kata dan dinyatakan dalam bahasaPada dasarnya logika memberikan banyakmanfaat bagi manusia dalam melakukan berbagai kegiatan.salah satunya dapatmembantu Melatih manusia agar dapat berpikirsecara kritis, rasional,lurus, tertib, metodis,koheren,dan dapat Meningkatkankesadaran manusiaakan pentingnya kebenaransehingga menghindari kesalahan dan kesesatan dalam berpikir.
MEKANISME PASAR ISLAMI
Authors: Sumirah R.R. Dhewi Putri Ayu
Published: December 2022

Pasar dalam pandangan islam yaitu bertemunya antara penjual dan pembeli dengan penentuan harga yang dilakukan oleh kekuatan pasar yaitu kekuatan permintaan dan penawaran. Permintaan merupakan salah satu elemen yang menggerakkan pasar, penawaran adalah kekuatan penting dalam pasar sebagai ketersediaan barang yang ada di pasar. Ekonomi Islam memandang bahwa pasar, negara, dari individu terletak pada keseimbangan, tidak boleh terdapat subordinat, sehingga salah satunya jadi dominan dari yang lain. Pasar menjamin kebebasannya dalam Islam. Konsep mekanisme pasar dalam Islam dapat dijelaskan pada masa Rasulullah dan Para pemikir ekonomi Islam.
LOGIKA WARFAHNI R(C1C122015)
Authors: R Warfahni
Published: December 2022

Dengan kata lain, objek materialnya yang dipelajari dalam ilmu logika adalah berpikir dengan penalaran, sedangkan objek formal logika adalah penalaran yang ditinjau dari segi ketepatannya. Logika juga penting dalam pelajaran matematika atau komputer.
Modul
Authors: MELIANA HESTI
Published: December 2022

Materi yang terdapat beberapa modul dan rpp
Differential expression of SLC47A2 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of SLC47A2, encoding solute carrier family 47 member 2, in the skeletal muscle of patients with ALS. SLC47A2 was also differentially expressed in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. SLC47A2 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS.
Differential expression of KLHL21 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of KLHL21, encoding kelch-like family member 21, in the skeletal muscle of patients with ALS. KLHL21 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. KLHL21 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
Comedy of technology : Silicon Valley and Million Dollar Extreme (Supplement I:7)
Authors: Akmut Camille
Published: December 2022

Supplement to the Historiography (of computer science and technology)
Tari Pedoa
Authors: Boys Isak Arsendu
Published: December 2022

Tarian Pado'a merupakan kegiatan yang tidak terpisahkan dari ritual adat lainnya seperti Banga Liwu, Buihi dan Hole. Tarian ini biasanya dilakukan pada malam hari sebelum dilakukan kegiatan Buihi besok harinya. Seperti pada umumnya kegiatan Pado'a diawali dengan ritual-ritual adat suguhan sirih pinang dan Kelapa Wangi (Kenana, Kelalla dan Nyiu Wau Mangngi) diatas Batu Persembahan atau Wowadu Turu. Sesudah acara pendahuluan ini lalu Mone Pejo atau tokoh yang dituakan dan dianggap mengerti tata caranya mulai melakukan koordinasi dengan para peserta yang hadir dan sudah siap dengan ketupat yang dibuat dari daun lontar serta berisi kacang hijau untuk diikat di kaki. Dalam Syair yang dilantunkan oleh Mone Pejo berisi puja dan puji kepada Sang Pencipta Alam Semesta dan Para Leluhur yang telah memberikan kesuburan, kemakmuran serta kelimpahan sehingga mereka telah panen hasil tanamannya, baik kacang hijau maupun jagung atau sorgum serta padi. Pandangan masyarakat Sabu sendiri terhadap Pado'a adalah merupakan suatu ajang kebahagiaan terutama kepada pemuda-pemudi yang dibolehkan untuk saling bergandengan satu sama lainnya atau dalam bahasa Sabu Pegai, Pegatti dengan caranya masing-masing. Sedangkan manfaat bagi orang tua acara ini merupakan suatu kesempatan bagi mereka untuk menjajakan jualan hasil kebun/panen. Selain itu juga bagi orang tua kegiatan Pado'a ini juga dijadikan sebagai arena hiburan dan pelepas lelah setelah mereka mengerjakan berbagai aktifitasnya. Kegiatan Pado'a ini biasanya berlansung selama tujuh hari saja dan sesudah acara Hole dilaksanakan oleh tokoh adat lokasi tempat Pado'a itu disiram dengan air gula sebagai pertanda kegiatan Pado'a berakhir.
Differential expression of ETS2 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of ETS2, encoding ETS proto-oncogene 2, transcription factor, in the skeletal muscle of patients with ALS. ETS2 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. ETS2 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
LOGIKA RISDA (C1C122013)
Authors: Risda
Published: December 2022

Apa itu logika? Logika adalah sebuah istilah yang berhubungan dengan pikiran manusia.Logika sebagai salah satu cabang ilmu filsafat yang dapat dipraktikkan dalam kehidupan sehari-hari. Dalam bidang filsafat sendiri, logika tidak dapat dipisahkan dalam proses mencari suatu kebenaran atau kesahihan. Untuk lebih mengenal cabang filsafat yang satu ini, Grameds dapat membaca buku karya Prof. Dr. Karomani. M. Si. dengan judul Pengantar Logika.
(ANALISIS SUMBER DAN PENGGUNAAN MODAL KERJA)
Authors: farida Puspa
Published: December 2022

AbstrakPengelolaan sumber dan penggunaan modal kerja di dalam suatu perusahaan yang baik dapat memperlancar suatu kegiatan proses produksi. Besar kecilnya modal kerja yang dibutuhkan oleh perusahaan di pengaruhi oleh besar kecilnya kegiatan usaha perusahaan yaitu produksi dan penjualan, tetapi antara modal kerja dengan hasil produksi harus seimbang, apabila modal kerja terlalu sedikit maka proses produksi tidak berjalan secara lancar, begitu pula sebaliknya modal kerja yang terlalu banyak maka proses produksi tidak efisien.Dengan menggunakan teknik (alat) analisis sumber dan penggunaan modal kerja, pengelola koperasi akan mengetahui bagaimana dana digunakan dan bagaimana dana tersebut dibelanjakan, selain itu dapat memperoleh informasi mengenai sebab-sebab terjadinya surplus (defisit) modal kerja selama periode tertentu, sehingga dapat digunakan sebagai dasar pengambilan keputusan tentang permodalan. Hasil laporan ini dilaporkan dalam laporan keuangan yang disebut laporan sumber dan penggunaan modal kerja.Kata kunci : Sumber modal kerja, Penggunaan modal kerja.
Differential expression of HMGN1 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: December 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published microarray data (3, 4). We found significant differential expression of HMGN1, encoding high mobility group nucleosome binding domain 1, in the skeletal muscle of patients with ALS. HMGN1 was also differentially expressed in primary motor neurons isolated from patients with ALS. HMGN1 transcript was present at significantly higher levels in skeletal muscle from patients with ALS as compared to skeletal muscle from control individuals. These analyses will begin to define the transcriptional landscape of ALS.
Logika
Authors: Safar Afridani Maula
Published: December 2022

Logika adalah sarana untuk berpikir sistematis, valid dan dapat dipertanggungjawabkan. Karena itu, berpikir logis adalah berpikir sesuai dengan aturan-aturan berpikir, seperti setengah tidak boleh lebih besar daripada satu. Logis dalam bahasa sehari-hari biasa disebut dengan masuk akal (Rapar, 1996)
Applying category theory to the study of consciousness?
Authors: Prentner Robert
Published: December 2022

What are the potential uses and misuses of applying category theory to the study of consciousness? We first review a recent proposal from the neurosciences of consciousness to illustrate the general approach using the integrated information theory of consciousness. We then propose possible avenues for further research, importantly also stressing the need to better develop the categorical representation of consciousness, in particular its phenomenological structure. A better understanding of consciousness cannot be achieved by merely studying the physical brain. By contrast, the categorical treatment suggests application in the domain of computer science and artificial intelligence research while also emphasizing the primacy of (first-personal) experience.
The component processes of complex planning follow distinct developmental trajectories
Authors: Ma Ili , Phaneuf Camille , van Opheusden Bas , Ma Wei Ji , Hartley Catherine A.
Published: December 2022

Developing the ability to plan is an important part of children’s transition into independent adults. Characterizing the development of planning ability in complex environments has been a longstanding interest in developmental science. Complex planning is known to involve multiple cognitive processes that enable the representation of the problem domain and the simulation of potential futures. To date, however, we lack a mechanistic account of how complex planning ability develops, in large part because prior developmental research has relied on tasks with small state spaces and analysis approaches that cannot effectively disentangle how multiple, distinct cognitive processes contribute to planning. Here, we address these shortcomings by leveraging a game-like planning task and a corresponding computational modeling framework, previously used in adults, to delineate the developmental trajectories of three component processes of complex planning. These processes include heuristic evaluation of prospective states based on relevant features, forward simulation of potential future actions and their outcomes (i.e., planning depth), and sustained attention to relevant features. Participants (ages 8-25 years) played the Four-in-a-row task, presented as a 4x9 board game, against computer opponents. This task assesses complex planning as it has too many potential future scenarios to exhaustively consider, a feature of many real-life planning scenarios. We found asynchronous age-related change in the component processes of complex planning, with the heuristic evaluation of relevant features rapidly improving from childhood into adolescence, and planning depth showing more protracted developmental improvements. Fewer attentional oversights predicted better planning but did not demonstrate age-related variability. Collectively, these results provide strong evidence for the continued development of model-based decision strategies into adulthood, and contribute to a more nuanced understanding of the cognitive mechanisms underpinning planning ability within complex environments at different developmental stages.
“Conscious Researchers in Unconscious Research”: A Motivational Revisit of Issues, Resolutions, and Applied Awareness in Backward Masking using Faces
Authors: Tsikandilakis Myron , Bali Persefoni , Karlis Alexandros-Konstantinos , Mével Pierre-Alexis , Madan Christopher R , Derrfuss Jan , Milbank Alison
Published: December 2022

In this manuscript, we provide a discourse of issues and resolutions that we should be conscious of when doing research in the unconscious using backward masking of faces. First, we revisit subjects that are contributing for understanding the unconscious as a concept. These involve historical episodes and early episodes of controversial experimentation. Subsequently, we revisit and discuss topical concepts, such as the metrics and the statistical analyses applied for assessing perception during backward masking. We proceed to discussing novel and developing issues relating to masked visual processing and contemporary psychophysics. We empirically illustrate how these issues bias experimental research. We present and empirically illustrate resolutions for these issues, such as the application of signal detection theory metrics, Bayesian analysis and advances in the psychophysics of masked presentations using faces. We assess whether and the extent to which we are truly conscious of established and known, and novel and developing issues and resolutions. We make use of backward masking as a rally point to emphasize the importance of conscious scholarly and methodological awareness for undertaking and advancing research in the unconscious.