bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetically determined plasma trefoil factor-3 levels are causally associated with the risk of ulcerative colitis: a Mendelian randomization study
Authors: TORAMAN Bayram , FİDAN Sami , YILDIZ Gökhan
Published: September 2023

Objectives: Ulcerative colitis (UC) is an inflammatory disease restricted to the colon's mucosal layer. UC is a complex disease with a largely unknown etiology. Mendelian Randomization (MR) is a method that uses variations in genes that have a causal effect of a modifiable exposure to the disease, in genetic epidemiological studies. Trefoil factor 3 (TFF3) is a secreted protein expressed mainly in the colonic mucosa that binds with the mucin 2 protein, forming a protective barrier for the colon mucosa from bacteria and other insults. This study aimed to identify if TFF3 levels in plasma are causally associated with UC.
Methods: We performed a two-sample MR study. For exposure instrumental variables (IVs), genetically determined TFF3 levels in plasma proteome quantitative trait locus data were obtained from the published literature. Outcome data were obtained from the GWAS catalog. The “TwoSampleMR” R package was used for MR. The statistical significance of IV effect sizes on the outcome is mainly evaluated by the inverse variance weighted (IVW) method.
Results: The IVW test showed considerable statistical significance in all analyzed outcomes except for Crohn’s disease (CD) samples. Heterogeneity and horizontal pleiotropy tests showed no significant results for MR sensitivity analysis.
Conclusions: We showed that TFF3 levels in plasma were causally associated with the risk of UC. Increased levels of TFF3 are reversely associated with the risk of UC. The absence of any causal relationship between TFF3 and CD from the same study cohort also supports our causal inference.
ФОРМУВАННЯ СТРАТЕГІЇ ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ МАЛОГО ТА СЕРЕДНЬОГО БІЗНЕСУ В УКРАЇНІ
Authors: Фролова Н. Л.
Published: September 2023

У статті досліджено сучасне становище малого та середнього бізнесу в Україні. Встановлено, що продовження бойових дій, подальше руйнування критичної інфраструктури, транспортного сектору, зростання операційних витрат, зниження доходів населення і відповідно його купівельної спроможності зумовили погіршення економічної активності малого та середнього бізнесу і поглиблення назрілих у даній сфері системних проблем. Досліджено державні ініціативи та пропозиції вчених щодо забезпечення економічної безпеки суб’єктів малого та середнього бізнесу. Доведено, що домінуючою глобальною тенденцією розвитку економіки на сьогодні є цифровізація, яка виступає основою трансформації галузей і видів діяльності, сприяє появі нових напрямів розвитку бізнесу і нових професій. Відзначаючи суттєві переваги цифровізації бізнесу, пов’язані зі прискоренням прийняття обґрунтованих управлінських рішень, якісним покращенням бізнес-процесів, скороченням транзакційних витрат, покращенням комунікації зі стейкхолдерами, диверсифікацією діяльності та підвищенням рентабельності, наголошено на потребі врахування цифрових ризиків економічній безпеці суб’єктів малого та середнього бізнесу. Доведено доцільність розгляду цифрової стійкості як ключового елементу забезпечення економічної безпеки суб’єктів малого та середнього бізнесу в умовах цифровізації. Розкрито етапи забезпечення економічної безпеки суб’єктів малого та середнього бізнесу в аспекті досягнення їх цифрової стійкості.
ОРГАНІЗАЦІЙНО-ЕКОНОМІЧНІ АСПЕКТИ УПРАВЛІННЯ ІНВЕСТИЦІЙНО-ІННОВАЦІЙНИМ РОЗВИТКОМ ТЕРИТОРІЙ
Authors: Пань Цзян
Published: September 2023

Встановлено, що на сучасному етапі важливого значення набуває створення організаційно-економічних умов для інвестиційно-інноваційного розвитку територій та регіонів, що можливо реалізувати шляхом розбудови такої інноваційної інфраструктури як технологічні та індустріальні парки. Досліджено вітчизняний досвід створення різного роду суб’єктів інноваційної інфраструктури, у т.ч. законодавчого забезпечення їх функціонування та інструментів державної підтримки їх створення. Розглянуто приклади світового досвіду розбудови технопарків. Обґрунтовано доцільність створення індустріального парку та віртуальної цифрової інфраструктури забезпечення його діяльності як базису активізації інвестиційноінноваційного розвитку територій та регіонів.
ФІНАНСОВИЙ РИЗИК-МЕНЕДЖМЕНТ НА ТРАНСПОРТІ
Authors: Кірдіна О. Г. , Стешенко О. Д.
Published: September 2023

В сучасних реаліях проблема класифікації, оцінки і обліку ризиків має істотне теоретичне і прикладне значення як важлива складова частина теорії і практики фінансового ризик-менеджменту на транспорті. Як показує досвід, управління ризиками здатне запобігати кризовим явищам, зменшити їх негативні наслідки, оздоровити фінансовий стан підприємств, підвищити їх конкурентоспроможність. Комплексний розгляд і докладна класифікація видів ризиків допоможе в побудові оптимальної системи фінансового ризик-менеджменту. Встановлено, що фінансові ризики мають різні джерела виникнення. Фінансові втрати за ними можуть бути пов’язані з факторами зовнішнього та внутрішнього характеру. Такі фінансові ризики можуть призводити до значних фінансових втрат і загрожувати фінансовій безпеці підприємства.
РЕСУРСНИЙ ПОТЕНЦІАЛ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ: СУТНІСТЬ ТА КЛЮЧОВІ СКЛАДОВІ
Authors: Корінь М. В. , Лановий О. А.
Published: September 2023

У статті досліджено визначення ресурсного потенціалу та подано систематизацію підходів до  класифікації його видів. Розкрито специфіку діяльності підприємств залізничного транспорту, що дозволило сформулювати авторське бачення категорії «ресурсний потенціал підприємств залізничного транспорту». Обґрунтовано та надано характеристику складових ресурсного потенціалу підприємств галузі. Встановлено заходи щодо залучення та забезпечення  раціонального використання ресурсного потенціалу підприємств галузі задля підтримки їх життєздатності і забезпечення сталого зростання.
ІНВЕСТИЦІЇ У ПІСЛЯВОЄННУ ВІДБУДОВУ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ УКРАЇНИ
Authors: Васильєв О. Л.
Published: September 2023

Проведено аналіз діяльності залізничного транспорту в першому півріччі 2022 р. Наведено попередні оцінки загальних прямих та непрямих втрат залізничного транспорту внаслідок російської військової агресії. Визначено короткострокові пріоритети інвестування в об’єкти залізничної інфраструктури. Запропоновано інвестиційні проєкти для відновлення роботи залізничного транспорту на середньостроковий період та стратегічну перспективу та можливі джерела їх фінансування.
ОСОБЛИВОСТІ ІННОВАЦІЙНОЇ ТРАНСФОРМАЦІЇ ПІДПРИЄМСТВ В УМОВАХ РОБОТИЗАЦІЇ
Authors: Овчиннікова В. О. , Дьяков М. І.
Published: September 2023

В статті встановлено, що  інноваційної трансформації підприємств України обумовлена кардинальною зміною світової економіки. Базисом для інноваційної  перебудови вітчизняних суб’єктів господарювання є впровадження у бізнес-процеси елементів штучного інтелекту, роботизованих технологій, інформаційних систем промислового інтернету, хмарних технологій, застосування об'ємних баз даних,  систем інтерактивного навчання, 3D-технологій, що забезпечать умови для мережевої інтеграції  інформаційних структур,  впроваджених у виробничі об'єкти,  технологічне обладнання, виробничі системи, системи управління  процесами та їх мережева взаємодія, яка має бути керованою та  адаптивною. Особливої уваги  заслуговує процес розвитку  роботизованих технологій.  Встановлено основні тенденції  розвитку робототехніки у світі.
ФОРМУВАННЯ СТРАТЕГІЧНИХ ЕКСПЕРТНИХ ГРУП ЯК ФАКТОР ЗАБЕЗПЕЧЕННЯ РОЗВИТКУ ВІТЧИЗНЯНИХ СУБ’ЄКТІВ ГОСПОДАРЮВАННЯ
Authors: Дикань О. В. , Косінцева П. Ю.
Published: September 2023

У статті досліджено умови та особливості функціонування вітчизняних суб’єктів господарювання. Встановлено, що загострення воєнного конфлікту  ускладнює й без того непрості умови ведення бізнесу, обумовлені цифровою трансформацією світової економіки та становленням  концепції «Індустрія 4.0». З’ясовано, що наразі своєчасним є пошук нових дієвих факторів забезпечення розвитку українського бізнесу. Доведено доцільність формування стратегічних експертних груп в межах сучасних підприємств, виділено особливості та етапи їх формування. Визначено, що результатом командної роботи та створення самої стратегічної групи експертів є повне та своєчасне досягнення встановлених стратегічних орієнтирів розвитку суб’єкта господарювання відповідно до принципів концепції «Індустрія 4.0» та своєчасне техніко-технологічне оновлення його виробничої бази, розвиток людського капіталу, підвищення рівня  конкурентоспроможності, зростання  продуктивності праці, підвищення якості продукції, зменшення її вартості, швидке постачання продукції та інше.
ФІСКАЛЬНА СТІЙКІСТЬ ЄВРОПЕЙСЬКИХ КРАЇН В КОНТЕКСТІ СУЧАСНИХ ВИКЛИКІВ ТА ЗАГРОЗ
Authors: Крихтіна Ю. О. , Карачарова К. А.
Published: September 2023

У статті проведено ідентифікацію проблемних зон і систематизовано виклики фіскальній стійкості, що стоять перед країнами Європейського Союзу. Серед основних викликів, що пов'язані зі стійкістю державних фінансів, виділено наступні: створення незалежних фіскальних інституцій, закони про фіскальну відповідальність, фіскальні правила та управління фіскальними ризиками. Встановлено, що європейські держави мають пристосуватися до непередбачених ситуацій, що не залежать від уряду, таких як великі коливання ділового циклу та супутні економічні кризи.
ЗАСТОСУВАННЯ ДЕЯКИХ АСПЕКТІВ ПСИХОЛОГІЇ УПРАВЛІННЯ ПЕРСОНАЛОМ НА ПІДПРИЄМСТВАХ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Яковенко В. Г. , Куделя В. І. , Челядінова Н. Г.
Published: September 2023

В статті проаналізовано праці вітчизняних вчених та практиків за представленою тематикою. Узагальнено заходи з психології управління персоналом. Підтверджено необхідність застосування елементів психології управління персоналом підприємств залізничного транспорту. Визначено основні психологічні особливості й риси в управлінні персоналом залізничного транспорту. Зазначено необхідність встановлення чинників для покращення психо-емоційного клімату колективі. Визначено, що для забезпечення ефективної роботи підприємств та плідної праці їх робітників є необхідним та доцільним застосовувати елементи психології управління. Розглянуто питання щодо ефективності застосування новітніх методів менеджменту персоналу.
Social Media in the Popular Turkish Newspapers
Authors: GENCEL BEK Mine
Published: September 2023

This article focuses on how social media is represented in newspapers by analyzing two popular Turkish newspapers in the last decade, from 2013 to 2021. The news was examined with qualitative content analysis supported by MAXQDA software which is used to generate codings from the text while reading each news item. The article first reviews the literature on social media and the news. Afterward, the findings of the textual analysis are shared with diagrams and in an organized way around the themes. Some chosen examples are discussed with a special focus on the visuals and the headlines which are translated. The article reveals that social media, starting as the mobilizing force during the Gezi protests, over the years, gained new meanings in the news. In conclusion, it is suggested to categorize the following represented themes from 2013 to 2021 under the two frames as negative and positive. While the first includes the themes of disinformation and harm, crime, and access problems, the positive frame consists of the themes of new apps, services and technology, publicity, and using social media campaigns for good causes.

The article argues how the newspapers, with the content of the news as these themes and with the form of the news with short, superficial, and under-investigated reporting as shown in the examples, in accordance with the context, amplify primarily authoritarianism and commercialism and ends with the suggestions.
Estudio de la regulación contable para pymes en Colombia: Una mirada desde las problemáticas en el contexto latinoamericano
Authors: Patiño Jacinto Ruth Alejandra , Melgarejo Molina Zuray Andrea , Valero Zapata Gloria Milena , Plata Becerra María Teresa
Published: September 2023

El presente documento se centra en la relevancia que tienen las pequeñas y medianas empresas (pymes) en el crecimiento económico de un país. Por ello, el objetivo del trabajo es analizar las alternativas normativas contables que han asumido, después de varios años, países como Colombia, Ecuador, Perú, Argentina y México, y algunos aspectos básicos de Chile, Bolivia y Brasil frente a los procesos de adopción de las NIIF para las pymes. Con ese propósito, se utiliza una metodología cualitativa, que parte de la revisión documental que se centra en dar cuenta de las problemáticas comunes y recurrentes del proceso de convergencia. Producto del respectivo análisis de contenido de los documentos encontrados, se establecen las siguientes categorías de las problemáticas encontradas: efectos del proceso de convergencia en los usuarios de la información financiera y la toma de decisiones, las asimetrías en el tratamiento contable en las NIIF para las pymes, los costos en la generación de la información, y algunos aspectos demográficos y particulares. Finalmente, se recogen las alternativas de regulación contable para las pymes que se han desarrollado en algunos países de Latinoamérica. Así, se encontró que algunos países, como Colombia, adoptaron la regulación contable para las pymes. Otros, como Argentina, permiten las NIIF para las pymes de forma voluntaria. Por su parte, México tiene normas locales y Brasil optó por la convergencia.
A percepção dos clientes em relação à proposta de valor dos escritórios de contabilidade
Authors: Ceccon de Quadros Thais , Sordi Schiavi Giovana , Da Silva Momo Fernanda , Rivero María Andrea
Published: September 2023

O objetivo do estudo é identificar a percepção do cliente em relação à proposta de valor entregue a partir dos serviços contábeis prestados por escritórios com estruturas e características diferentes. Por isso, foi realizada uma pesquisa qualitativa e descritiva, desenvolvida por meio de entrevistas com clientes e documentos de escritórios contábeis. O estudo teve como ponto central a análise dos serviços prestados pelos escritórios tradicionais, escritórios digitais e escritórios inteiramente online. A pesquisa apresenta as variedades de escritórios contábeis que existem atualmente, relacionando-os com o impacto tecnológico, os serviços prestados e as propostas de valor entregues. Com foco na proposta de valor, a pesquisa revela a opinião e visão do cliente como fator-chave de estruturação e diferenciação dos negócios contábeis. A partir das entrevistas, quatro entrevistados de cada tipologia de escritório contábil, o estudo apresentou resultados positivos sobre a inserção tecnológica nos escritórios de contabilidade, mostrando que os modelos tradicionais estão, a cada dia, se adaptando com a “Era Digital”.Já os escritórios digitais e online, se mostram eficazes no rápido atendimento ao cliente, porém suas análises gerenciais e acompanhamento das necessidades da empresa ainda são limitadas. O estudo contribui para a literatura, que conta com uma escassez de pesquisas que reflitam a percepção do cliente sobre a proposta de valor dos escritórios contábeis. Assim como, demonstra o impacto da tecnologia nos processos de atividades contábeis e a exemplificação de seu crescente desenvolvimento nos escritórios.
Efeitos da liderança transformacional e da responsabilidade social corporativa no comprometimento e cidadania organizacional
Authors: Da Silva Lucila Xavier , Soares Marques Narcélio José , Pereira Saraiva Monike , Horz Vagner , Capuano da Cruz Ana Paula
Published: September 2023

O estudo objetiva analisar os efeitos da liderança transformacional e da percepção de responsabilidade social corporativa (RSC) no comprometimento e cidadania organizacional de gestores, de uma das maiores instituições bancárias da América Latina. Com base na revisão da literatura, seis hipóteses foram desenvolvidas e testadas por meio de modelagem de equações estruturais (PLS-SEM), reunindo evidências de 163 gestores. Os principais achados revelam que para a amostra investigada, a liderança transformacional e a RSC influenciam diretamente o comprometimento organizacional, e indiretamente a cidadania organizacional. Também foi constatado que a liderança transformacional incentiva o desenvolvimento da percepção de RSC. Os achados indicam que o esforço em manter uma empresa socialmente responsável traz benefícios no comprometimento organizacional e levam a um benefício positivo na cidadania organizacional. Assim, a expectativa é que se tenham cada vez mais empresas socialmente responsáveis, com incentivo as práticas de RSC por meio de programas, cursos e capacitações e entregando valores de RSC, o que traz reflexos à sociedade, visto que com esses traços e estímulos, as pessoas tendem a trabalhar de maneira mais comprometida e com comportamento positivo provindo dos funcionários, tem-se maior empregabilidade, desenvolvimento pessoal e motivação a esses profissionais, além de eventualmente, também poder gerar benefícios para a região.
Beyond Greed: Why Armed Groups Tax
Authors: Bandula-Irwin Tanya , Gallien Max , Jackson Ashley , van den Boogaard Vanessa , Weigand Florian
Published: September 2023

Armed groups tax. Journalistic accounts often have a tone of surprise about this fact, while policy reports tend to strike a tone of alarm, highlighting the link between armed group taxation and ongoing conflict. Policymakers often focus on targeting the mechanisms of armed group taxation as part of their conflict strategy, often described as ‘following the money’. We argue that what is instead needed is a deeper understanding of the nuanced realities of armed group taxation, the motivations behind it, and the implications it has for an armed group’s relationship with civilian and diaspora populations, as well as the broader international community. We build on two distinct literatures, on armed groups and on taxation, to provide the first systematic exploration into the motivation of armed group taxation. Based on a review of the diverse practices of how armed groups tax, we highlight that a full account of the groups’ motivations needs to go beyond revenue motivations, and engage with key themes around legitimacy, control of populations, institution building, and the performance of public authority. Summary of Working Paper 131.
A Study on Mythic Motifes in Olga Tokarczuk’s Primeval and Other Times
Authors:   East European and Balkan Institute, Choi Sungeun
Published: September 2023

Polish writer Olga Tokarczuk’s Primeval and Other Times(1996), the most representative novel from the early period of her work, is widely considered to beautifully embody a mythological imagination. Consisting of eighty-four episodes, the novel is a unique work in that it integrates events which actually occurred in Poland into a fictional story set against the background of an imaginary village called ‘Primeval’. Notably, the word ‘primeval’, which means ‘the earliest time in history’, is used to name a place. Through the imaginary village of Primeval, Tokarczuk has created a new and distinctive world in which reality and supernatural phenomena co-exist, and unfolded mythic time with the characteristics of ‘circularity’ and ‘roundness’ within a special space. Tokarczuk reveals the robustness of the literary archetype originating from universal human sentiment through the various mythical motifs embedded in the novel. As such, Primeval is a microcosm in which reality and myth co-exist. With this novel Tokarczuk sought to emphasize the everlasting presence of myth, proving that all great novels are grounded in some kind of myth.
European Capital of Culture Policy and Urban Development Plan for Rijeka, Croatia
Authors:   East European and Balkan Institute, Kim Sang Hun
Published: September 2023

It was only in 2004 that the European Union, originally composed of Western European countries, began to include the so-called Eastern European countries (Latvia, Lithuania, Slovakia, Slovenia, Estonia, the Czech Republic, Poland, and Hungary), which had transitioned from socialism to democracy. This was followed by Romania and Bulgaria joining in 2007 and Croatia in 2013. The very nature of the European continent, with its diverse peoples, languages, histories, and cultures, has undoubtedly necessitated policies that recognize, acknowledge, and seek to reduce differences as much as possible, with the ultimate goal of uniting them. In particular, the EU member states, which were originally composed of Western European countries, may have been in dire need of policies to bridge the gap with the countries that underwent communism after World War II, as many of them joined the EU in the 2000s. The policy direction of cultural integration with former communist countries aligns with the general trend of European integration. However, it is being promoted in various ways, taking into consideration the special history and situation of these countries. The goal is to provide opportunities for people to understand each other's history and culture, fostering interactions that contribute to overcoming cultural differences and forming strong bonds. In particular, the former communist countries have an economic gap with existing EU member states due to past political and economic changes. The EU is working to provide economic infrastructure and industrial support to these countries, strengthen cooperation, and promote cultural integration with Western European countries. Such directions and policies continue to be promoted for cultural integration between existing EU member states and former communist countries. Examples of these initiatives include the European Capital of Culture project and the Erasmus Program, which aim to foster cultural understanding and integration among future generations through education, ultimately working towards the goal of European integration. In any case, it is clear that the country of 'Croatia' and the city of 'Rijeka,' which gained independence from the former Yugoslavia in 1991 and were not initially recognized by not only European citizens but also the world, seized the opportunity of the European Capital of Culture 2020 project to establish closer communication and cooperation with Europe and the global community. We expect that they will continue progressing on the path of 'integration' while preserving 'cultural diversity' in the future.
Práticas contraceptivas entre universitárias da área da saúde
Authors: Leal Stephanie Pereira , Pereira Nalisson Marques
Published: September 2023

Objetivo: Descrever o padrão das práticas contraceptivas, subdividas entre hormonais e não-hormonais, entre estudantes dos cursos de saúde de uma universidade da Amazônia. Metodologia: Trata-se de um estudo transversal, descritivo, de abordagem quantitativa, conduzido com 254 estudantes do sexo feminino dos cursos de Enfermagem, Farmácia, Fisioterapia e Medicina. Os dados foram obtidos online, catalogados em planilhas e filtrados para cálculo e análise estatística descritiva. Resultados: Metade das estudantes relatou fazer uso de contracepção hormonal. A idade média de início para uso de contracepção hormonal foi de 18,2 anos. Dentre as 126 estudantes que não faziam contracepção hormonal, 76 relataram uso do preservativo masculino como forma de anticoncepção e 39 afirmaram não fazer uso de qualquer método, por razões como ausência de relação sexual, homossexualidade ou escolha pessoal. Conclusão: A prevalência da adoção de métodos contraceptivos, tanto hormonais como não hormonais, entre estudantes da área da saúde é superior à média nacional entre mulheres com escolaridade maior ou igual a 12 anos.
A wearable assistive system for the visually impaired using object detection, distance measurement and tactile presentation
Authors: Chen Yiwen , Shen Junjie , Sawada Hideyuki
Published: September 2023

With the current development of society, ensuring traffic and walking safety for the visually impaired is becoming increasingly important. We propose a wearable system based on a system previously developed by us that uses object recognition, a distance measurement function, and the corresponding vibration pattern presentation to support the mobility of the visually impaired. The system recognizes obstacles in front of a user in real time, measures their distances, processes the information, and then presents safety actions through vibration patterns from a tactile glove woven with shape memory alloy (SMA) actuators. The deep learning model is compressed to achieve real-time recognition using a microcomputer while maintaining recognition accuracy. Measurements of the distances to multiple objects are realized using a stereo camera, and vibration patterns are presented through a tactile glove in response to these distances. Experiments are conducted to verify the system performance to provide safe navigation depending on the positions and the distances of multiple obstacles in front of the user.
Exact Solution of Decaying Turbulence
Authors: Migdal Alexander
Published: September 2023

We have found an infinite dimensional manifold of exact solutions of the Navier-Stokes loop equation for the Wilson loop in decaying Turbulence in arbitrary dimension $d >2$. This solution family is equivalent to a fractal curve in complex space $\mathbb C^d$ with random steps parametrized by $N$ Ising variables $\sigma_i=\pm 1$, in addition to a rational number $\frac{p}{q}$ and an integer winding number $r$, related by $\sum \sigma_i = q r$. This equivalence provides a \textbf{dual} theory describing a strong turbulent phase of the Navier-Stokes flow in $\mathbb R_d$ space as a random geometry in a different space, like ADS/CFT correspondence in gauge theory. This is a \textbf{quantum} statistical system with integer-valued parameters, satisfying some number theory constraints. Its long-range interaction leads to critical phenomena when its size $N \rightarrow \infty$ or its chemical potential $\mu \rightarrow 0$. The system with fixed $N$ has different asymptotics at odd and even $N\rightarrow \infty$, but the limit $\mu \rightarrow 0$ is well defined. The energy dissipation rate is analytically calculated as a function of $\mu$ using methods of number theory. It grows as $\nu/\mu^2$ in the continuum limit $\mu \rightarrow 0$, leading to anomalous dissipation at $\mu \propto \sqrt{\nu} \to 0$. The same method is used to compute all the moments of the enstrophy distribution. The small perturbation of the fixed manifold satisfies the linear equation we solved in a general form. This perturbation decays as $t^{-\lambda}$, where the anomalous dimensions $\lambda$ satisfy the spectral equation \eqref{spectralEq}. The spectrum becomes a continuum in the statistical limit $N \to \infty$, leading to multifractal phenomena.
Impact Pressure Influence of Flood on Bridge Deck under Sediment Deposition Conditions: An Experimental Study
Authors: Niu Zhipan , Long Yi , Meng Chuke , Yang Hang , Luo Yihan , Zhao Weiyang
Published: September 2023

This paper investigates the impact of sediment deposition and inflow conditions on horizontal impact pressure and frequency analysis of bridge deck vibrations during flooding. Flooding-induced pressure and vibrations contribute to bridge collapse, and sediment deposition influences water flow and impact pressure. The study explores the relationship between sediment deposition height and impact pressure, revealing a significant increase as sediment approaches 50% of bridge deck clearance. Sediment amplifies impact pressure response to flow velocity changes. The dimensionless sediment deposition height has a greater influence on impact pressure compared to the inflow Froude number. Two distinct frequencies, dominant and secondary, are identified for impact pressure and water level fluctuations. Dominant frequencies positively correlate with sediment deposition height and Froude number, indicating an increasing trend. Secondary frequencies remain stable (0.31-0.58 Hz). These findings enhance understanding of flow dynamics and bridge-flow interaction in sediment-deposited channels, providing theoretical support for evaluating and managing disasters related to bridges in such environments. Overall, this research contributes to the field of bridge engineering and supports improved design and maintenance practices for bridges exposed to sediment-deposited channels.
Spatial-numeric method application to the movable wedge problem for Physics First pedagogy
Authors: Dehipawala Sunil , Shekoyan Vazgen , Holden Todd , Cheung Tak
Published: September 2023

The objective is to solve the college physics problem of a block sliding down a movable smooth wedge without friction anywhere using a spatial-numeric perspective.  The drawing method used the sum of the normal force and weight of the block to find the wedge acceleration.  The drawing method results are equivalent to the algebra method results within drawing accuracy.  The result of a geometric construction with regular drawing uncertainly was shown for the case without any horizontal applied force.  For the case of a given horizontal applied force, an additional numeric graphing method was shown with additional drawing uncertainty in the result.  The geometric construction without graphing resuted in solving the horizontal applied force case via scaling in the concept of modified gravity experienced by the block on the wedge’s slant edge, assuming a pre-requisite knowledge of algebra and trigonometry.  The presented spatial numeric method and results imply a Physics First pedagogy of using the spatial numeric abilities,  with the inclusion of the pre-projectile problem, pre-traffic-light problem, and post-collision problem in a one-semester syllabus.
Inhalable SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Authors: Ye Tong , Jiao Zhouguang , Li Xin , He Zhanlong , Li Yanyan , Yang Fengmei , Zhao Xin , Wang Youchun , Huang Weijin , Qin Meng , Feng Yingmei , Qiu Yefeng , Yang Wenhui , Hu Lingfei , Hu Yaling , Zhai Yu , Wang Erqiang , Yu Di , Wang Shuang , Yue Hua , Wang Yishu , Wang Hengliang , Zhu Li , Ma Guanghui , Wei Wei
Published: September 2023

The coronavirus disease pandemic has fostered major advances in vaccination technologies; however, there are urgent needs for vaccines that induce mucosal immune responses and single-dose, noninvasive administration. Here, we develop an inhalable, single-dose, dry powder aerosol SARS-CoV-2 vaccine that induces potent systemic and mucosal immune responses. Our vaccine encapsulates proteinaceous cholera toxin B subunit-assembled nanoparticles displaying the SARS-CoV-2 RBD antigen within microcapsules of optimal aerodynamic size, and this unique nano-micro coupled structure supports efficient alveoli delivery, sustained antigen release, and antigen-presenting cell uptake, which are favourable features for induction of immune responses. Moreover, our vaccine successfully induces strong production of IgG and IgA, as well as a local T-cell response, collectively conferring effective protection against SARS-CoV-2 in mice, hamsters, and nonhuman primates. Finally, we also demonstrate a “mosaic iteration” of our vaccine that codisplays ancestral and Omicron antigens, extending the breadth of antibody response against cocirculating strains and transmission of the Omicron variant. These findings support our inhalable vaccine as a promising multivalent platform for fighting COVID-19 or other respiratory infectious diseases.
Dynamics of a three-phase polymer/fiber/CNT laminated nanocomposite conical shell with nonuniform thickness
Authors: Darakhsh Arashk , Rahmani Saeed , Amirabadi Hossein , Sarafraz Mirsalman , Afshari Hassan
Published: September 2023

In the presented paper, the free vibration of a polymer/fiber/CNT laminated nanocomposite conical shell with nonuniform thickness and surrounded by an elastic two-parameter foundation are analyzed. The shell is made of a polymeric matrix enriched simultaneously with randomly oriented carbon nanotubes (CNTs) and aligned glass fibers. CNTs agglomeration is included and the density and elastic constants of such a three-phase nanocomposite are calculated using the rule of mixture and the Eshelby–Mori–Tanaka approach alongside Hanh’s homogenization method. The conical shell and the elastic foundation are modeled using the first-order shear deformation theory (FSDT) and the Pasternak foundation model, consecutively. The governing equations are derived using Hamilton’s principle and are solved numerically via the differential quadrature method (DQM). The impacts of several parameters on the natural frequencies of such a structure are discussed such as thickness variation parameters, mass fraction and chirality of the CNTs, mass fraction of the fibers, and boundary conditions. It is observed that by considering the specific value for the average thickness of the shell, the thickness variation parameters associated with the highest natural frequency are different in various vibrational modes. It is discovered that, the natural frequencies grow by increasing mass fraction of the CNTs, but the influences of mass fraction of the fibers on the natural frequencies are strongly dependent on the vibration mode.
Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma
Authors: Hu Yao , Zhang Qingyun , Wu Zhiyuan , Chen Kun , Xu Xiao , Ma Weizhe , Chen Bobin , Jin Limin , Guan Ming
Published: September 2023

Background
To improve early diagnosis and chemotherapy efficacy monitoring in primary central nervous system lymphoma (PCNSL), cerebrospinal fluid (CSF) exosomal microRNA (miRNA) studies were performed.
Method
Small RNA sequencing was performed to identify candidate exosomal miRNAs as CSF biopsy biomarkers from two patients with de novo PCNSL and two patients in remission after chemotherapy. miR-200c and miR-141 expression in CSF exosomes was further validated using relative quantitative real-time polymerase chain reaction in patients with PCNSL (n = 20), patients with other neurological diseases (n = 10), and normal subjects (n = 10). Receiver operating characteristic (ROC) curve analyses of miR-200c and miR-141 in the diagnosis and prediction of chemotherapy efficacy in PCNSL were performed in patients treated with methotrexate. Additionally, bioinformatics tools were utilized to predict the potential targets of miR-200c and miR-141.
Results
Exosomal miR-200c and miR-141 levels in CSF from patients with PCNSL were significantly lower than those in control subjects. Importantly, miR-200c and miR-141 were upregulated in patients with PCNSL after chemotherapy (P = 0.002). There was a significant correlation between the levels of miR-141 and IL-10 in CSF (P = 0.04). The combination of miR-200c and miR-141 yielded an area under the ROC curve of 0.761 for distinguishing PCNSL with sensitivity and specificity of 60.0% and 96.7%, respectively. The potential target genes of miR-200c and miR-141 in PCNSL included ATP1B3, DYNC1H1, MATR3, NUCKS1, ZNF638, NUDT4, RCN2, GNPDA1, ZBTB38, and DOLK.
Conclusion
Collectively, miR-200c and miR-141 are likely to be upregulated in CSF exosomes after chemotherapy in patients with PCNSL, highlighting their potential as reliable liquid biopsy biomarkers for PCNSL diagnosis and chemotherapy efficacy monitoring.
A Phase 2 Evaluation of a New Flavored Peg and Sulfate Solution Compared to an Over-the-counter Laxative, Peg and Sports Drink Bowel Preparation Combination
Authors: Wiener Gregory , Winkle Peter , McGowan John D. , Cleveland Mark vB. , Palma Jack A. Di
Published: September 2023

Background:
Acceptability and tolerance of bowel preparation is critical to overcome patient hesitancy in undergoing colon cancer screening and surveillance colonoscopy. To improve patient experience, a new sports drink-flavored bowel preparation containing polyethylene glycol (PEG) and sulfate salts (FPSS) was developed to provide a similar experience to a commonly used but not unapproved PEG and sports drink bowel preparation (PEG-SD), while also achieving improved cleansing efficacy.
Methods:
This FPSS preparation, approved by the United States Food and Drug Administration in June 2023, was evaluated in a non-randomized Phase 2 study in which 40 patients requiring colonoscopy were prepared with FPSS and 20 with PEG-SD.
Results:
Overall cleansing success was high with FPSS based on unblinded local endoscopist assessment (93%) and blinded central reading (97%), exceeding PEG-SD which achieved success rates of 84% (local read), 74% and 68% (blinded central reads). Similar differences favoring FPSS were seen for excellent preparations and cleansing success by colon segment as rated by local endoscopists. Both preparations were well-tolerated, with 93% of FPSS patients rating their preparation as Tolerable to Very Easy to consume, compared to 100% of PEG-SD. Patients who had previously taken a preparation for colonoscopy found FPSS and PEG-SD better than their prior preparation (73% and 70%, respectively) and nearly all would request their assigned study preparation again in the future. About two thirds of FPSS patients agreed that the preparation tasted similar to a sports drink.
Conclusion:
The new sports drink-like flavored preparation compares favorably to PEG-SD for bowel cleansing efficacy while achieving similar patient satisfaction. The study was registered at www.clinicaltrials.gov (NCT03328507).
Feature Selection Algorithm Based on CFS Algorithm Emphasizing Data Discrimination
Authors: Liu Zhuo , Wang Chensheng , Li Ge
Published: September 2023

In the training of the neural network model, the large number of features in the data set will lead to the complexity of the network model and high time cost. Therefore, the feature selection operation of the original data set is carried out to select the feature subset conducive to model training to improve the model's performance. The traditional feature selection algorithm has the problems of a thin process and needs help to eliminate the features with small discrimination. Therefore, this paper proposes the discrimination filtering formula and DI-CFS feature selection algorithm. The discrimination filtering formula can filter out invalid features and inefficient features with small discrimination. DI-CFS algorithm combines discrimination filtering formula, isolation forest algorithm, and improved CFS algorithm. On a set of wind turbine data, the DI-CFS algorithm and other traditional feature selection algorithms are used to select features from the data, respectively, and the obtained feature subsets are input into the same neural network model for training and performing classification tasks. The experimental results show that the discrimination filtering formula has a positive effect, and the DI-CFS algorithm has a better feature selection effect.
Haplotype diversity of Heterodera koreana (Tylenchida: Heteroderidae), affecting bamboo in Korea
Authors: Kang Heonil , Ko Hyoung-Rai , Lim Yeon-Jeong , Park Eun-Hyeong , Kim Eun-Hwa , Park Se-Keun , Park Byeong-Yong , Han Hyerim
Published: September 2023

In a survey of plant-parasitic nematodes in agricultural fields, cyst-forming nematodes were found in soil planted bamboo in Korea. The aim of this study was to identify the cyst nematodes based on morphological and molecular characteristics. As the results, the morphology and morphometrics of cysts and second-stage juveniles (J2s) were consistent with those of previous descriptions of Heterodera koreana. In phylogenetic analyses based on DNA sequences, these cyst nematodes were clustered together with clade of H. koreana in internal transcribed spacer (ITS) region, and large subunit D2-D3 segments (LSU D2-D3). These nematodes were clustered together with clade of H. koreana in cytochrome c oxidase subunit I (COI) gene, but a haplotype was different when compared with previous reported haplotypes (haplotype A-C) in Japan. This study showed these cyst nematodes were identified as H. koreana, and a new haplotype of H. koreana is distributed in Korea. We suggest that the new haplotype of H. koreana name as haplotype D.
Running a Super SDM (Species Distribution Model) ‘in the cloud’ for Better Habitat- Associations, Predictions and Inference: Applying Open Access Big Data, Machine Learning Ensembles on Great Gray Owls in Alaska
Authors: Huettmann Falk , Andrews Phillip , Steiner Moriz , Das Arghya Kusum , Philip Jacques , Chunrong Mi , Bryans Nathaniel , Barker Bryan
Published: September 2023

The currently available distribution range maps for the Great Grey Owl (GGOW; Strix nebulosa) are rather coarse, imprecise, outdated, often hand-drawn and thus not quantified or scientific even. In this study, we present a proof of concept with a biological application for technical and biological workflow progress on latest global open access Big Data sharing, Open-source methods of R and geographic information systems (OGIS and QGIS) assessed with recent citizen-science sightings of the GGOW. This proposed workflow can be applied on the inference for species-habitat models such as typically applied with species distribution models (SDMs). Using Random Forest – an ensemble-type model of Machine Learning following Leo Breiman’s approach of inference from predictions - we present a Super SDM for Great Gray Owls in Alaska running on Oracle Cloud Infrastructure (OCI). These Super SDMs were based on best-publicly data (410 occurrences + 1% new assessment sightings) and over 100 environmental GIS habitat predictors. The compiled global open access data and the associated workflow achieve for the first time to overcome limitations for traditionally used PC and laptops (technological computing limitations), breaking new ground and have real-world implications for conservation and land management for GGOW, Alaska, and other species worldwide as a ‘new’ baseline. As this research field remains dynamic, SuperSDMs are not the ultimate and final statement on species-habitat associations yet, but they summarize all publicly available data and information on a topic allowing fine-tuning and improvements as needed. At minimum, it’s a great leap forward to be more ecological and inclusive. Using GGOWs, here we aim to correct the perception of this species towards a more inclusive, holistic, and scientifically correct assessment of this human-environment inhabiting owl in the Anthropocene, rather than a mysterious wilderness-inhabiting species (aka ‘Phantom of the North’). Such a Super SDM was never created for any bird species before and opens up new perspectives for impact assessment policy and global sustainability.
Assessment of the alpha 7 nicotinic acetylcholine receptor as an imaging marker of cardiac repair-associated processes using NS14490
Authors: Reid Victoria JM , McLoughlin Wesley KX , Stott Holly , Iškauskienė Monika , Sackus Algirdas , Marti Judit A , Kurian Dominic , Wishart Thomas M , Lucatelli Christophe , Peters Dan , Gray Gillian A , Baker Andrew H , Newby David E , Hadoke Patrick WF , Tavares Adriana AS , MacAskill Mark G
Published: September 2023

Background
Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Non-invasive imaging using a radiotracer targeting these processes could provide a key research tool to understand the underlying mechanisms in cardiac wound healing. Activation of the alpha7 nicotinic acetylcholine receptor (ɑ7nAChR) stimulates pro-reparative macrophage activity and angiogenesis. We investigated whether this target could serve as an imaging biomarker for these interlinked wound healing responses by assessing in vitro cellular expression and by using a tritiated-version of the PET radiotracer [18F]NS14490 in tissue autoradiography studies.
Results
ɑ7nAChR expression in monocyte-derived macrophages and vascular cells showed the highest relative expression was within macrophages, but only endothelial cells exhibited a proliferation and hypoxia driven increase in expression. Using a mouse model of inflammatory angiogenesis following sponge implantation, specific binding of [3H]NS14490 increased from 3.6 ± 0.2 µCi/g at day 3 post-implantation to 4.9 ± 0.2 µCi/g at day 7 (n = 4, p < 0.01), followed by a reduction in specific binding at days 14 and 21. This peak matched the onset of vessel formation and macrophage infiltration. In a rat MI model, specific binding of [3H]NS14490 was low within the myocardium of the sham cohort and the remote myocardium of the MI cohort. Specific binding within the infarcted myocardium increased from day 14 post-MI (33.8 ± 14.1 µCi/g, P ≤ 0.01 versus sham), peaking at day 28 (48.9 ± 5.1 µCi/g, P ≤ 0.0001 versus sham). Histological and proteomic profiling of ɑ7nAChR positive MI tissue revealed strong associations between the ɑ7nAChR signal and extracellular matrix deposition.
Conclusion
ɑ7nAChR is highly expressed in macrophages and showed proliferation and hypoxia driven expression in endothelial cells. While NS14490 imaging displays a pattern that coincides with vessel formation and macrophage infiltration in the sponge model, this is not the case in the MI model where the ɑ7nAChR signal strongly associated with extracellular matrix deposition. Overall, these findings support the involvement of ɑ7nAChR across several processes central to cardiac repair and warrant further investigation to assess the role of ɑ7nAChR in fibrosis and establish the relationship with cardiac function during adverse remodelling.
Impact of family support on the cognitive functions of Egyptian older population
Authors: Moustafa Sara , Gaballah Nada , Heikal Shimaa , Salama Mohamed
Published: September 2023

Background: Social support is essential in the daily activities of the older population, which can impact their cognitive functions over time.
Aim of the study: This study investigates the hypothesis that there is a link between social support and cognitive function in the older population living in the Egyptian community using the Arabic translation of the Survey of Health, Ageing, Retirement in Europe (SHARE) questionnaire.
Subjects and methods: Cross-sectional analytic study was conducted as a part of the pilot study for A Longitudinal Study of Egyptian Healthy Ageing (AL-SEHA) project. It included 299 participants (50+ years of age). Investigators collected data using the Arabic translation of the SHARE questionnaire in five Egyptian Universities. Data were then uploaded to the Social Research Centre (SRC) at the.
Results: The prevalence of declined cognitive functions was 39.467% (95% CI: 33.89-45.04). Cognitive impairment was significantly less among university and postgraduate degree holders (p<0.001), marital status (p=0.0378) or contact frequency by their children (p=0.0364).
Conclusion: Being married, with a university degree or higher, and increased contact frequency with children, all showed positive correlation with cognitive function in our sample. In conclusion, this research contributes to our understanding of the impact of family network and support and cognitive function in the older Egyptian population. Our findings can be a base to add on to the literature.
Diagnostic evaluation of institutions as a basis for designing the Brazilian maturity model of telehealth services.
Authors: Silva Angélica Baptista , Pisa Ivan Torres , Messina Luiz Ary , Pelogi Andréa Pereira Simões , Tenório Josceli Maria , Sousa Fernando Sequeira , Santos Daniela Lacerda , Maia Jessi , Filha Ianê Germano de Andrade , Guedes Ana Cristina Carneiro Menezes , Lopes Paulo Roberto de Lima , Maia Paulo Ricardo da Silva
Published: September 2023

Background
The number and specificities of telehealth service units that expanded their services and diversified with the COVID-19 pandemic in Brazil need to be discovered. The objective of this manuscript is to present a methodology for the diagnostic evaluation of 19 telehealth units from different regions of the country for federal governmental decision-making.
Methods
A cross-sectional quantitative and qualitative study was carried out in the form of a census based on administrative records with an online survey and in-depth interviews with local telehealth managers.
Results
Despite the discontinuity of regular funding, the results point to a diversity of initiatives and advances. Citizenship, sustainability, security, and budget management are recurring themes in the maturity analysis of telehealth services after the advent of the pandemic.
Conclusion
It is necessary for Brazil to build a resilient model of the maturity of telehealth services that contemplates the different regional scenarios.