bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of tislelizumab (T) combined with gemcitabine and cisplatin (GC) for patients with localized muscle-invasive bladder cancer (MIBC) after radical transurethral resection of bladder tumor/partial cystectomy: A prospective, phase II study.
Authors: Cao Ming , Xiao Dongdong , Xue Wei
Published: February 2025

784

Background:
Transurethral resection of bladder tumor (TURBT) combined with concurrent chemoradiotherapy is the standard treatment for bladder preservation in MIBC. TURBT alone and partial cystectomy are only suitable for selected patients with solitary tumors, T2, and tumors in the bladder diverticulum while patients could have tumor recurrence after surgery. This prospective phase II study aims to explore the efficacy and safety of T combined with GC after radical TURBT or partial cystectomy as bladder preservation therapy in patients with PD-L1 positive MIBC.
Methods:
Eligible patients had clinical stage T2-T3N0M0, histologically confirmed PD-L1 positive urothelial carcinoma, no prior systemic treatment, and no residual tumor after radical TURBT or partial cystectomy. Patients received T combined with GC within 8 weeks of local treatment (G 1000mg/m2, d1, d8; C 70mg/m2, d1, IV, q3w, for a total of 6 cycles. T 200mg, d8, IV, q3w, for a total of 8 cycles). The primary endpoint was 1-year bladder intact disease-free survival rate. Secondary endpoints included 2-year bladder intact disease-free survival rate, metastasis-free survival, time to salvage cystectomy, overall survival, and safety.
Results:
From August 2022 to October 2024, a total of 13 patients were enrolled in the study. Median age was 70 years (65-75). Twelve patients were staged as pT2 and 1 patient had pT3. Twelve patients were evaluable for efficacy and 1 patient withdrew the consent. Seven patients underwent TURBT and 5 patients underwent partial cystectomy. Median follow-up time was 8.0 months. One patient had non-muscle-invasive bladder cancer recurrence and receive intravesical BCG instillation while the remains had no recurrence of disease. 1-year bladder-intact disease-free survival rate was 100%. Grade 3 or higher adverse events occurred in 33.3% of patients. No new safety signals were observed.
Conclusions:
The study demonstrated that combination of T and GC after complete resection of tumor seemed promising as bladder preservation strategy in selected patients. Further recruitment is ongoing. Clinical trial information:
NCT05401279
.
Long-term outcomes of neoadjuvant chemotherapy (NAC) before bladder-sparing chemoradiotherapy (CRT) for patients with nonmetastatic muscle-invasive bladder cancer (MIBC).
Authors: Mahoney Meghan Elizabeth , Meija Nely , Atenafu Eshetu G. , Chung Peter W. M. , Zlotta Alex , Alimohamed Nimira S. , Fleshner Neil , Lo Gregory , Kulkarni Girish S. , Berlin Alejandro , Bristow Robert G. , Jiang Maria , Sridhar Srikala S.
Published: February 2025

819

Background:
Neoadjuvant cisplatin-based combination chemotherapy followed by concurrent chemoradiation is an emerging approach in carefully selected MIBC patients who opt for bladder sparing however, long-term data on its efficacy and tolerability remains lacking. We evaluated long-term outcomes in MIBC patients treated with this approach.
Methods:
We conducted a retrospective chart review of patients treated with NAC followed by CRT bladder sparing approaches between 2008 and 2017 at the Princess Margaret Cancer Centre and Lakeridge Health Cancer Centers. We initially published the feasibility of this approach and early outcome data in 2018. In this analysis, we updated long-term disease free survival (DFS), bladder intact disease free survival (BI-DFS) and overall survival (OS).
Results:
In total 57 patients were treated with NAC + CRT. Most were male with a median age of 72 (range 45-87), and an Eastern Cooperative Oncology Group performance status of 0 (60%) or 1 (40%). Patients with stage II (65%), and stage III disease (25%), as well as regional nodal metastases (11%), carcinoma in situ (28%) and hydronephrosis (25%) were included. The majority of patients completed planned NAC (95%). All patients completed external-beam radiotherapy, and 84% completed at least 60% of the planned concurrent weekly cisplatin doses. Median follow up for this population was 74.4 months (9.7-142.1). At the time of this updated analysis, 23/57 (40%) recurred, local recurrence occurred in 11/57 patients (19%), and 9/57 patients (16%) required salvage cystectomy. Distant recurrence occurred in 12/57 (21%) patients, all of whom died as a result of bladder cancer. The median DFS for the study population was 56.7 months (95% CI 25.3-99.1), and 5-year DFS rate was 49%. The median BI-DFS was 40.1 months (95% CI 23.3-85.4) and 5-year BI-DFS rate was 45%. The median OS was 104.9 months (95% CI 60.8-119.2) with a 5-year OS rate of 65% (95% CI 50.7-75.5).
Conclusions:
NAC+CRT is a safe and effective approach for selected patients with MIBC with encouraging long-term outcomes. This data supports evaluating neoadjuvant and adjuvant systemic therapies along with bladder preservation strategies in prospective clinical trials.
Bipolar androgen therapy (BAT) for nonmetastatic castration-resistant prostate (nmCRPC) cancer progressing on darolutamide: Working Out M0 BAT (WOMBAT; ANZUP 2201).
Authors: Crumbaker Megan , Krieger Laurence , Pook David William , Davis Ian D. , Fontela Antoinette , Oldmeadow Christopher , Hurwitz Josh , Inderjeeth Andrisha Jade , Dhillon Haryana M. , Downton Teesha , Marx Gavin M. , Shekar Samantha , Antonarakis Emmanuel S. , Denmeade Samuel R. , Anton Angelyn , Tan Thean Hsiang , Sharma Sharad , Goh Jeffrey C. , Horvath Lisa , Joshua Anthony M. ,   The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP)
Published: February 2025

TPS298

Background:
The backbone of prostate cancer systemic treatment is androgen deprivation therapy (ADT) increasingly with the use of androgen receptor pathway inhibitors (ARPIs). Mechanisms for ARPI resistance include amplification of the androgen receptor (AR), overexpression of AR variants, aberrant AR activity, and autocrine/paracrine androgen synthesis in tumour cells. Preclinical and clinical studies have identified that bipolar androgen therapy (BAT) may restore the sensitivity of prostate cancer to ARPIs. We plan to test this hypothesis in patients with PSA progression on darolutamide for non-metastatic castrate resistant prostate cancer.
Methods:
WOMBAT (ANZUP 2201, NCT06594926, ACTRN12624000582550) is a single-arm phase 2 trial. The primary endpoint is to determine metastasis-free survival (MFS; time from commencing BAT to evidence of metastases or death, by conventional imaging as per PCWG3 criteria). Secondary endpoints include toxicity of BAT and darolutamide; effects on health-related quality of life; efficacy measures (PSA response rate; PSA progression-free survival); effects of BAT and darolutamide on bone turnover. Inclusion criteria include: PSA progression on darolutamide for nmCRPC; M0 on conventional imaging. Treatment consists of BAT (IM testosterone enanthate 500mg) day 1 and darolutamide 600mg bd days 29-56 (of a 56-day cycle) with ongoing ADT. The total sample size of 69 (with a first stage of enrolment of 44) is calculated to demonstrate an increase in the proportion of participants without detectable metastases at 6 months from 56.1% to 66.7% (corresponding to a median MFS improvement from 7.2 to 10.27 months, HR 0.6) with a one-sided type I error of α = 10% and power of 80%, based on benchmarks from the ARAMIS trial of darolutamide in nmCRPC. Enrolment has commenced at 8 sites around Australia. Clinical trial information:
ACTRN12624000582550
.
LuCarbo: A phase 1a/1b trial of
177
Lu-PSMA-617 (LuPSMA) with carboplatin in advanced prostate cancer.
Authors: Ravi Praful , Xie Wanling , Paul Morgan , Healy Erin , Lilienfeld Amanda , LaBrecque Nicole , Wolanski Andrew , Ritzer Jolivette , Serzan Michael Thomas , Tewari Alok , Jacene Heather
Published: February 2025

TPS304

Background:
LuPSMA is a proven life-prolonging therapy in men with metastatic castrate-resistant prostate cancer (mCRPC) who have previously received a taxane and an androgen receptor pathway inhibitor (ARPI). Despite patient selection by PSMA-PET/CT, responses are only seen in 50% of patients with PSMA-avid disease and are generally not durable. The mechanism of LuPSMA relies on delivery of beta emissions upon target engagement, thereby leading to DNA damage. Carboplatin is an inexpensive and widely available agent used as a radiosensitizer in other solid tumors and often combined with a taxane in CRPC. Given the need to improve outcomes with LuPSMA and the mechanisms of action of both agents, there is a rationale to evaluate the combination of LuPSMA with carboplatin in mCRPC.
Methods:
This is a single-center phase 1a/1b trial of LuPSMA and carboplatin. Patients with mCRPC who have previously received ≥1 taxane and ≥1 ARPI and have PSMA-avid disease on baseline PSMA-PET/CT are eligible. LuPSMA is given at the standard dose of 7.4GBq every 6 weeks, and carboplatin is dosed every 3 weeks, with 6 weeks constituting 1 cycle. In phase 1a, a 3+3 design is used with 3 planned dose levels of carboplatin (DL1 – AUC2; DL2 – AUC3: DL3 – AUC4); the dose-limiting toxicity (DLT) period is during cycle 1, and the recommended phase 2 dose (RP2D) will be the highest administered dose level with ≤1 DLTs out of 6 treated patients. In phase 1b, 19 patients will be enrolled at the RP2D (for a total of 25 patients treated at RP2D), and these patients will additionally undergo baseline and on-therapy research biopsies and an on-therapy PSMA-PET/CT after 2 cycles. The primary objective is to evaluate the safety of the combination and establish the RP2D; secondary objectives include overall response rate (PSA50 – reduction in PSA by ≥50% - and objective response rate, per RECIST 1.1), radiographic progression-free survival (per RECIST 1.1/PCWG3) and overall survival. Exploratory objectives include evaluation of genomic, transcriptomic, proteomic, and imaging biomarkers of response and resistance. With a sample size of 25 patients treated at RP2D, the combination will be deemed effective if 15 or more PSA50 responses are seen; the probability of concluding that the combination is effective is ≤0.1 if its true PSA50 rate is ≤45% and ≥0.9 if the true PSA50 rate is ≥70%. The study was activated in May 2024, and a total of 6 patients have been enrolled to date. Clinical trial information:
NCT06303713
.
Addressing Clinical Challenges in Aberrant Pharmacokinetics of Biologic Therapeutic Drugs: Investigating Sample Processing Procedure in the Immunoassays
Authors: Chen Yih-Wen , Davenport Olinda , Yu Nancy , Melendez Rachel , Nugteren James , Nijem Ihsan , Yan Weili , Hendricks Robert , Song Yuan
Published: February 2025

Bioanalytical Pharmacokinetics (PK) methods are designed for robust performance under rigorous regulatory compliance requirements to ensure the generated data is reliable and maintains integrity. In a phase 1 dose-finding clinical study, aberrant PK profiles of two co-administered biologics drugs were observed. Unexpectedly, we discovered high fill levels in collection tubes from the majority of samples. This led to the hypothesis that the highly filled tubes might cause difficulty in achieving complete sample thaw and thorough mixing at the time of sample analysis, potentially contributing to the abnormalities observed in the PK dataset. Evaluation of the impact of sample fill levels and processing procedure can be challenging since PK concentrations of study samples were unknown. Therefore, a systematic approach was employed to conduct a thorough examination using mock samples. The data illustrate a correlation between sample thawing and mixing process and the variability in the PK data. The concentrations from properly filled mock samples that underwent complete thawing and mixing showed 100% data reproducibility. In contrast, the concentrations from fully filled mock samples that did not follow the proper procedure showed sample recovery deviating by ± 30% from nominal value and exhibited considerable lack of precision. This data identified the root cause of aberrant PK, justifying revised sample preparation guidance and sample re-assay. Improved sample handling and subsequent reassay resolved the aberrant PK profile issues. In conclusion, this study reiterated that sample handling plays a crucial role in quality and reproducibility of PK data with immunoassays.

Graphical Abstract
Materials Compatibility Considerations for the Transition to Low Global Warming Potential Propellants for Pressurized Metered Dose Inhalers
Authors: Dohmeier Dan , Sen Atish , Cavecchi Alessandro , Matos João , Lostritto Richard , Nagao Lee
Published: February 2025

Pressurized metered dose inhalers (pMDI) are a vital therapy for the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). In pMDI, the propellants used to deliver the drug to the lungs are hydrofluorocarbons (HFC). However, the current HFCs in use have large global warming potential (GWP). In order to reduce or eliminate the use of propellants with large global warming potential, efforts are underway within the pharmaceutical industry to transition to the use of low GWP propellants in pMDI, while maintaining their effectiveness in treating disease. The current switch from higher GWP propellants mirrors the switch from chlorofluorocarbon (CFC) propellants to HFCs undertaken in the 1990’s, which was driven by ozone depletion concerns. In this paper, the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS) discusses aspects of the switch to low GWP propellants from the perspective of materials compatibility of pMDI components with low GWP propellants. Leveraging the learnings and advances in pMDI component materials implemented following the switch from CFCs, industry is well positioned to make the change. This paper describes the utility of the low GWP propellants being developed for use in pMDI and the learnings from the previous transition that are being leveraged by industry. The current state of development will be described, including a review of available literature supporting the transition to low GWP propellants.
Good Hair, Bad Math
Authors: Rand Erica
Published: February 2025

While most policing of gender categorization in sport concerns a human unit of one, I've been maneuvering, since 2019, within a human unit of two, as part of a white, queer, gender-nonconforming pairs team with my figure skating partner Anna Kellar. Situating our training and activism within the growing movement for change in the sport, this piece considers some of our experiences, the challenges, and deep pleasures as we work to advance the skills and rule changes required to test and compete; to navigate racialized gender binarism and cis-heteronormitivity sedimented in training, rule, and custom; and to develop performance vocabularies to legibly represent queer gender.
The Influence of Tumor Burden Score and Lymph Node Metastasis on the Survival Benefit of Adjuvant Chemotherapy in Intrahepatic Cholangiocarcinoma
Authors: Kawashima Jun , Endo Yutaka , Woldesenbet Selamawit , Khalil Mujtaba , Akabane Miho , Cauchy François , Shen Feng , Maithel Shishir , Popescu Irinel , Kitago Minoru , Weiss Matthew J. , Martel Guillaume , Pulitano Carlo , Aldrighetti Luca , Poultsides George , Ruzzente Andrea , Bauer Todd W. , Gleisner Ana , Marques Hugo , Groot Koerkamp Bas , Endo Itaru , Pawlik Timothy M.
Published: February 2025

Introduction

While postoperative adjuvant chemotherapy (AC) is generally recommended for intrahepatic cholangiocarcinoma (ICC), its benefit remains debated. This study aimed to identify patients that may benefit from AC following liver resection of ICC.

Methods

Patients who underwent liver resection for ICC between 2000 and 2023 were identified from an international multi-institutional database. Individual multivariable Cox models were used to evaluate the interaction between each prognostic factor and the effect of AC on survival.

Results

Among 1412 patients, 431 (30.5%) received AC. Both higher tumor burden score (TBS; hazard ratio [HR] 0.95, 95% confidence interval [CI] 0.91–1.00; p = 0.033) and metastatic lymph node status (HR 0.58, 95% CI 0.38–0.89; p = 0.014) demonstrated interactions with the survival benefit from receipt of AC. Interaction plots highlighted how AC was associated with improved survival beyond a TBS of approximately 6. Notably, among 555 (39.3%) patients with TBS <6 and N0 or Nx status, 5-year overall survival (OS) was no different between patients who received AC versus individuals who did not (55.1% [95% CI 48.9–62.1] vs. 58.7% [95% CI 49.8–69.2]; p = 0.900). In contrast, among 857 (60.7%) patients with TBS ≥6 or N1 status, AC was associated with improved 5-year OS (30.7% [95% CI 26.2–36.0] vs. 33.0% [95% CI 26.9–40.5]; p = 0.018).

Conclusions

TBS and lymph node status may be useful in a multidisciplinary setting to inform decisions about AC planning for ICC patients following curative-intent resection.
Maternal and perinatal death surveillance and response in Bangladesh: A case study on measuring impact through health information systems
Authors: Sayem Abu Sadat Mohammad , Kaasbøll Jens Johan , Halim Abul , Abdullah Dr. Abu Sayeed Md.
Published: February 2025

The information systems for the Maternal and Perinatal Death Surveillance and Response (MPDSR) program have been digitalized in Bangladesh since 2014. This study aimed to investigate the availability of information systems for measuring the status of an MPDSR program and the planning process and actions developed based on real-time information. This study explored innovative information systems designed to easily monitor and measure the impact of health programs. The study included both the primary and secondary data. Key informant interviews were conducted to explore the enablers and strengths of information systems. Secondary data were collected from government websites and approved MPDSR action plans. This study highlights the potential and challenges of governmental health information systems in notifying maternal and neonatal deaths. The study reveals that the existing death notification rates are not up to national standards. It is encouraging to see health managers develop action plans and address this issue. The MPDSR information system serves as an essential tool for health managers, enabling them to assess variations in maternal and perinatal mortality rates while facilitating the development of interventions tailored to local needs. However, several obstacles must be addressed, such as insufficient data, lack of monitoring, and irregularities in MPDSR review meetings. By finding ways to overcome these challenges, we can unlock the full potential of MPDSR and improve maternal and neonatal health outcomes. The success of an MPDSR program relies on how the information is utilized to take action and measure the outcome. Advanced information systems, such as health dashboards, scorecards, and administrative data, can play a vital role in measuring the progress and impact of a program. The primary challenge lies in capturing all deaths, including their causes, and having the capacity to analyze the data effectively to develop action plans for health managers.
Examining the effects of anxiety and education level on mental health: The role of spiritual intelligence as an intervening variable in post COVID-19 patients in Indonesia
Authors: Ansyori Anis , Yunus Ahmad , Imam Sentot , Peristiowati Yuly
Published: February 2025

Background The COVID-19 pandemic has profoundly affected global health systems and daily life, exacerbating vulnerabilities, particularly in Indonesia. This study investigates the impact of anxiety and education level on mental health, with spiritual intelligence as an intervening variable among post-COVID-19 patients in Indonesia. Methods Utilizing a cross-sectional design, data were collected from 390 post-COVID-19 patients in Indonesia. Structured questionnaires assessed anxiety, education level, spiritual intelligence, and mental health. Structural Equation Modeling (SEM) was used to analyze the relationships among these variables. Results The findings indicate that anxiety significantly affects both spiritual intelligence and mental health, with spiritual intelligence acting as a mediating factor. Additionally, higher educational attainment is positively associated with enhanced spiritual intelligence and improved mental health outcomes. Conclusions The study underscores the importance of incorporating spiritual development practices into mental health interventions and educational programs to boost resilience and overall well-being in the post-pandemic era. While these findings are promising, the cross-sectional design limits causal inferences, and future research should consider longitudinal studies to examine these relationships over time. These practices can help mitigate the adverse effects of anxiety and educational disparities on mental health.
Expediency of Dynamic Pricing Application (part 2)
Authors: Boldycheva A. , Saharova N.
Published: February 2025

In the conditions of digitalization and high competition dynamic pricing turns from a tool of choice into a necessary element of successful business strategy. Its implementation allows not only to adapt to market changes, but also to use them in its favor, providing a sustainable competitive advantage. Dynamic pricing allows companies to adapt prices depending on changing factors such as demand, competition or seasonality. This article analyzes the conditions and feasibility of dynamic pricing in different industries. To avoid technical, ethical and legal problems, companies should take into account the quality of data, its origin and use, as well as respect the rights and interests of customers. This approach not only minimizes risks but also helps to build brand trust.
On the Problem of Effective Limitation of Price Growth in the Interests of More Complete Use of the Country’s Economic Development Potential
Authors: Laptev Sergey , Filina F.
Published: February 2025

The article examines the reasons for the insufficiently effective anti-inflation policy in Russia and concludes that the Central Bank, currently responsible for anti-inflation policy, does not have all the necessary means to implement it. It is established that limiting the money supply in the economy is not enough to radically slow down price growth. It is proposed to build an anti-inflation policy on the basis of strategic management with the division of functions for influencing key inflation factors between individual economic departments that have the appropriate powers and means of influence.
Respiratory Complications and Management in Duchenne Muscular Dystrophy and Amyotrophic Lateral Sclerosis
Authors: Huzarski Filip , Marta Patrycja Kinga , Ossolińska Agata , Ferfecka Gabriela Monika , Pawełek Klaudia Anna , Stolarska Lucyna , Rosa-Bończak Magdalena , Morawiecka Natalia , Kłosowicz Weronika , Carlton Olivier
Published: February 2025

Introduction:
Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS) are rare recessive genetic disorders. Both conditions lead to a range of systemic complications, including those affecting the respiratory system. Respiratory and cardiovascular complications are identified as the most common causes of mortality in individuals with DMD and ALS. Early diagnosis of reduced respiratory parameters can delay the progression of respiratory system involvement. Available therapies, including gene therapy, pharmacological approaches, and conservative methods, can slow disease progression and prevent respiratory complications.
Aim of the study:
The aim of this study was to analyze the available treatment methods for Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS), with a particular focus on respiratory complications.
Materials and Methods:
A non-systematic review of scientific articles was conducted using the keywords “spinal muscular atrophy,” “Duchenne muscular dystrophy,” and “respiratory.” The review was performed in the PubMed and Google Scholar databases, analyzing a total of 31 sources published between 2008 and 2024.
Conclusions:
Early diagnosis of DMD or ALS is crucial for extending life expectancy and delaying the onset of adverse complications, including those affecting the skeletal, cardiovascular, and respiratory systems. Currently, a broad range of therapeutic options is available to alleviate the daily challenges faced by patients and their families. Preventive measures and prompt responses to complications are essential to halt and delay further disease progression.
Ketamine in the Treatment of Depression
Authors: Kaczmarska Urszula Agnieszka , Cioch Michał Jakub , Nowak Julia , Woźniak Aleksandra , Hermanowicz Kamil , Najdek Agnieszka , Oleksy Daria , Komada Dawid , Doman Katarzyna , Mycyk Marcin
Published: February 2025

Introduction
Depression is one of the most common mental illnesses. Over the course of a lifetime, several percent of the adult population suffers from depression. There are many treatments for depression like pharmacotherapy and psychotherapy.  In this article, we wanted to focus on the effectiveness of ketamine in treating depression.
Aim of study
The study aimed to summarize the available knowledge on the use of ketamine in the treatment of depression. The epidemiology, etiology, side effects, and treatment methods, were summarized and described.
Materials and method
The literature available in the PubMed database was reviewed using the following keywords: “Ketamine”,” Depression”, and “Antidepressants”.
Conclusion
Without a doubt, ketamine has proven to be a new advocate for mental health research and therapeutics. After over half a century without novel targets for MDD (Major Depressive Disorder) treatment, the observation of ketamine’s rapid antidepressant effects in treatment-resistant depression has become a promising field that could represent a breakthrough in the understanding of MDD, and the possibility of reducing some of the major personal and global burden that depression is responsible for. It seems imminent then that a new era of different acting antidepressant strategies is upon us, and it is our responsibility to make a critical analysis of the potential benefits and harm inherent to novel therapeutics.
Impact of war stress on oral healt
Authors: Boitsaniuk Svitlana , Levkiv Mariana , Zaliznyak Marta , Manashchuk Nadiia , Patskan Liudmyla , Pohoretska Khrystyna , Chornii Nataliia
Published: February 2025

Wartime  greatly elevate the frequency, intensity, and severity of oral health issues among military personnel. This research outlines the complex effects of combat on oral health. It was revealed a high prevalence of periodontal problems and varying levels of dental caries in those affected. The conditions of war significantly impact the rise and seriousness of oral diseases among professional soldiers and those who are internally displaced.
Aim. The research aims to determine the relationship between stress and oral health in individuals exposed to chronic stress in wartime.
Materials and methods. The study was conducted on 68 professional soldiers in the Ukraine Army and 42 internally displaced persons. The control group consisted of 39 patients. The study was based on clinical examination and a questionnaire.
Results. Notable variations exist between the groups in wartime and peacetime based on how often they brush their teeth daily and their diet. A group of soldiers had significantly poorer oral health than civilians. According to the plaque index, аmong the military, only 7.1% have good oral hygiene (plaque index 0.0), 53.6% have fair oral hygiene (plaque index 0.1-1.9), and 39.3% have bad oral hygiene (plaque index 2.0-3.0).
Conclusion. Participation in war and time spent on battlefields have had a significant influence on the increased prevalence and severity of periodontal disease, decay, and diet.
Cough as the first symptom of chronic heart failure: A case report of a 72-year-old woman
Authors: Sroczyńska Paulina , Sroczyński Jan , Mielczarek Maja
Published: February 2025

Heart failure (HF) is defined as a clinical syndrome characterized by several key symptoms, which may be accompanied by physical signs. The prevalence of HF among adults in developed countries is approximately 1%–2%, and its frequency increases with age. HF is classified into three types: heart failure with preserved ejection fraction (HFpEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF).
The aim of this paper is to present the subtle clinical manifestation and diagnostic process based on the case of a 72-year-old female patient. This is a case-based report. The research method involved the analysis of a clinical case, utilizing the patient's medical records and test results as the primary tools. The diagnostic techniques included a review of the patient's documentation and relevant literature.
The first section outlines the pathophysiological basis, symptoms, classification, and treatment of heart failure. The diagnostic pathway of the patient is described, focusing on her initial presentation with mild cough without other clinical symptoms that could indicate the final diagnosis.
Echocardiography is one of the key diagnostic methods in chronic heart failure, but chest X-ray imaging can provide valuable clues when determining the etiology of symptoms presented by patients in primary care settings.
Review of the Literature on the Impact of Teriparatide Use on Bone Healing
Authors: Bielecka Larysa
Published: February 2025

Introduction

Fractures, especially hip fractures, represent a growing health issue in aging societies. Recovery of mobility after such an injury can be prolonged and not always complete, affecting patients' quality of life. Modern medicine is exploring methods to support healing, including parathyroid hormone (PTH) therapy, which stimulates bone tissue formation, opening new perspectives in fracture treatment.

Aim of the study

The objective of this study is to review current scientific reports and summarize the existing knowledge on the impact of teriparatide supplementation on bone healing after fractures. 

Materials and Methods

A review of randomized clinical trials (RCTs) published between 2016 and 2024 regarding the impact of teriparatide use on bone healing. Four studies meeting specific selection criteria were identified.

Results

The majority of analyzed studies demonstrated that the use of teriparatide improves bone mineral density. This effect was particularly pronounced among patients with prolonged teriparatide administration. In certain studies (e.g., those by Lee SY and Huang), a faster bone healing process and improved radiographic outcomes were observed in patients receiving teriparatide. Patients undergoing teriparatide supplementation reported reduced pain perception and improved mobility compared to control groups, suggesting a positive impact of the therapy on patients' quality of life during the recovery period.

Conclusions
The use of teriparatide shows potential as an effective therapy to enhance recovery after bone fractures.
Atención de violencia: construcción de una estrategia intercultural en salud mental para el pueblo tikuna, Amazonas (2017-2019)
Authors: Gómez Peñaloza Sheila Andrea , Cadavid Mónica
Published: February 2025

Introducción: la violencia familiar y comunitaria es un problema que afecta a la población indígena Tikuna, los Magüta, de la comunidad de Arara (Amazonas, Colombia). Tradicionalmente abordado desde su propia cosmovisión y mal comprendido desde la perspectiva occidental. Sin embargo, un trabajo articulado posibilitaría una atención más efectiva. Se planteó como objetivo proponer una estrategia intercultural en salud mental que aporte a dar respuesta a las necesidades de atención de la violencia familiar y comunitaria. Materiales y métodos: estudio cualitativo etnográfico exploratorio. Incluyó técnicas de recolección de información convencionales (observación participante, entrevistas semiestructuradas, grupos focales, revisión documental y árbol de problemas, diarios de campo) y no convencionales (mingas de pensamiento con médicos tradicionales, conversaciones en la chagra y talleres de música y reconocimiento emocional). Resultados: la estrategia intercultural en salud mental para la atención de la violencia familiar y comunitaria consta de tres líneas: reconocimiento del contexto, acciones de intervención basadas en el diálogo intercultural y una propuesta para la promoción de acciones comunitarias que favorezcan la salud mental. Conclusión: se identifica la pertinencia de una estrategia intercultural en salud mental intercultural porque se logró reconocer que las experiencias de violencia familiar y comunitaria son el resultado de la desobediencia de los mandatos de origen que se establecen desde la historia de este pueblo; por eso se plantea que el uso de la ritualidad sea posibilitado para que complemente el tratamiento institucional de esta problemática, favoreciendo la salud mental individual y colectiva de esta comunidad.
INTELIGÊNCIA ARTIFICIAL GENERATIVA NA EDUCAÇÃO SUPERIOR: APORTES PARA UMA PRÁTICA PEDAGÓGICA CRÍTICO-REFLEXIVA
Authors: Santo Eniel do Espírito , Souza Sales Mary Valda , Carvalho Ottoni André Luiz
Published: February 2025

A recente massificação da inteligência artificial generativa (IAG) vem causando um movimento crítico e reflexivo no campo da educação, tendo em vista as suas potencialidades que evidenciam desafiadoras questões. Considerando tal contexto, este estudo analisou os aportes crítico-reflexivos acerca da compreensão de IAG, expondo questões pedagógicas relacionadas com a formação e possibilidades didáticas, com foco no cenário da educação superior. Buscou-se, como indicação metodológica, desenvolver uma pesquisa exploratória e descritiva, de abordagem qualitativa, utilizando-se a pesquisa bibliográfica como suporte para o estudo de caso realizado no contexto do ensino superior, com 175 estudantes vinculados a um curso de formação continuada de professores, isto é, a pós-graduação lato sensu em Tecnologias e Educação Aberta e Digital, da Universidade Federal do Recôncavo da Bahia (UFRB). Em relação à inserção da IAG na prática pedagógica,  26 (16,2%) dos participantes consideraram indiferente, pouco oportuno ou não oportuno e 123 (76,4%) dos respondentes a consideram muito oportuna como dispositivo potencializador do processo educativo. As narrativas dos participantes revelam preocupação com a falta de conhecimento e lacunas formativas no desenvolvimento de competências e fluência digital. Contudo, as potencialidades de integração da IAG na prática pedagógica, evidenciadas nas narrativas dos participantes, remetem-nos a variadas possibilidades no contexto do processo de ensino e aprendizagem. O estudo conclui que  a inserção da IAG na educação superior requer cuidadosa análise crítica e conhecimento das potencialidades dessa tecnologia, valorizando-se o contexto social, político e econômico e, sobretudo, estabelecendo-se um processo dialógico de reflexão crítica, alinhado com a promoção da formação emancipatória e cidadã.
A EPISTEME DA TECNOLOGIA E A EDUCAÇÃO
Authors: Rangel Lorencini Raissa , Fehlberg de Souza Nadir
Published: February 2025

O presente artigo, por meio de uma análise documental e bibliográfica, apoiando-se no pensamento de Morin (2005, 2007, 2015), Kuhn (1988) , Santos (2010) e Behrens (2001), aborda a temática da implementação tecnológica na educação, como os desafios que essa ação exige, não apenas na criação e realização de políticas públicas que subsidiem essa implementação, mas também às urgências em formação, estrutura e otimização dos objetivos da ação relatada, além de examinar o impacto das tecnologias no ensino-aprendizagem. Pensar em tecnologia e, conjuntamente, em seu impacto na forma e tempos de comunicação, significa interação com algum artefato tecnológico, logo a escola não pode caminhar na contramão da sociedade. Conclui-se que se torna evidente a emergência em orientar os estudantes para o letramento digital de forma a construir processos comunicativos que rompam com os paradigmas mais complexos construídos sobre pilares de desigualdade, bem como analisar as novas possibilidades de aprendizagem que as tecnologias propiciam, sem abandonar a visão de que o tecnológico não substitui o humano e nem tudo que advém da tecnologia provoca impactos positivos e, a ruptura de paradigmas historicamente sustentados, dificilmente se dará sem a implementação de políticas que perpassem, no mínimo, pela equidade de oferta dessa mesma educação que se quer transformar. Isso envolve reconhecer a complexidade dos sistemas de tecnologias, incorporar uma ética robusta em seu desenvolvimento, democratizar o acesso ao conhecimento tecnológico e promover a sustentabilidade.
GPT PAULO FREIRE: CONVERSANDO COM UMA SIMULAÇÃO DO PATRONO DA EDUCAÇÃO BRASILEIRA
Authors: Pimentel Mariano , De Paula Berino Aristóteles
Published: February 2025

Neste artigo, apresentamos o GPT Paulo Freire, uma simulação de Paulo Freire possibilitada pela Inteligência Artificial Generativa (IAGen). Para sua criação, utilizamos o serviço GPTs, que possibilita atribuir um papel para o ChatGPT performar e possibilita criar uma base de conhecimento para apoiar a geração de suas respostas. Comparamos esse chatbot com o do episódio "Volto Já" da série Black Mirror, refletindo sobre as implicações sociais e emocionais das interações com simulações de indivíduos falecidos baseadas em seus rastros digitais. Discutimos o potencial, as limitações e desafios educacionais dessa tecnologia a partir da análise das reações e declarações de estudantes e professores-pesquisadores ao estabelecerem as primeiras conversas com essa simulação do patrono da educação brasileira. Ressaltamos a necessidade de se fazer um uso crítico, reflexivo e criativo dessa IAGen na educação, destacando a importância de uma abordagem pedagógica alinhada aos princípios freirianos, que promova o diálogo, a cocriação, a curiosidade, a imaginação, a capacidade de conjecturar, de comparar, de duvidar das respostas geradas e de buscar fontes confiáveis, visando desenvolver o pensamento crítico e a conscientização dos aprendentes.
DIÁLOGOS FREIRIANOS E INTELIGÊNCIA ARTIFICIAL
Authors: Farbiarz Alexandre , Coaracy Lucas Lima
Published: February 2025

Este artigo traz resultados parciais de uma revisão bibliográfica objetivando a discussão do conceito de “literacIA” e sua importância para educadores e educandos. Tal conceito se configura como uma junção dos termos “literacia” e “Inteligência Artificial (IA)” e é fundamentado no pensamento de Paulo Freire e Freire e Guimarães acerca da relação entre educação e tecnologia. Defendemos uma apropriação da IA na educação que seja pautada na cidadania, crítica aos modos de produção e manutenção das IAs e aos vieses discriminatórios presentes nestas. Para tal, a literacIA é discutida enquanto perspectiva que estimula uma postura curiosa e crítica, capaz de refletir sobre os males que circulam em torno dessa tecnologia e usá-la com propósitos feministas, antirracistas e decoloniais.
LETRAMENTOS NA ACADEM.IA: INTERSEÇÃO ENTRE O CHATGPT E O LETRAMENTO DIGITAL CRÍTICO NA PRODUÇÃO DE TRABALHOS ACADÊMICOS
Authors: Fajardo Turbin Ana Emília , Armando Cañas Chávez Fidel , Andrade Messias Wesley , Mendes Morais Fernanda
Published: February 2025

O uso da Inteligência Artificial (IA), especialmente do ChatGPT, tem se expandido no contexto educacional, levantando debates sobre seu impacto na produção acadêmica. Esta pesquisa investiga como o ChatGPT pode contribuir para a elaboração de ensaio acadêmico, considerando suas potencialidades e desafios. A abordagem teórica baseia-se nos conceitos de língua e linguagem de Bakhtin (1992) e Mey (1998), na mediação vygotskiana e no letramento digital crítico, conforme Trevisan, Maciel e Fernandes (2021). Metodologicamente, conduzimos uma pesquisa documental analisando o processo de escrita de uma pós-graduanda em Linguística Aplicada. Os resultados indicam que a estudante utilizou o ChatGPT para checagem teórica e levantamento bibliográfico, mas, em vez de copiar as respostas geradas, recriou criticamente o texto, integrando reflexões próprias e referências acadêmicas. Concluímos, portanto, que o ChatGPT pode ser um suporte na escrita acadêmica quando usado de maneira crítica e ética, promovendo a reflexão e o aprimoramento da produção textual
Palavras-chave: Inteligência Artificial; ChatGPT; Mediação; Letramento Digital Crítico; Escrita Acadêmica.
INNOVACIÓN EN METODOLOGÍA DOCENTE UNIVERSITARIA EN LA DISCIPLINA DE TRABAJO SOCIAL
Authors: Centenero de Arce Fátima , Sánchez Rivas Mª Virginia
Published: February 2025

Con este trabajo se pretende abordar y motivar sobre la oportunidad que el proceso de convergencia de la educación superior en el espacio europeo impulsado por el Acuerdo de Bolonia en 1999 para promover el debate sobre la innovación en la formación universitaria y en concreto en Trabajo Social. La preocupación por la calidad y producción científica, ha sido y sigue siendo una constante en la docencia del Trabajo Social en nuestro país. La naturaleza misma de esta profesión de ayuda plantea exigencias tanto en términos de rigor en los conocimientos teóricos, metodológicos y técnicos, como en relación con los métodos docentes empleados.
Como destaca Báñez (2004), la formación en Trabajo Social va más allá de la simple transmisión de conocimientos teóricos; implica capacitar a los estudiantes para aplicar esos conocimientos en procesos de intervención social. En este contexto, la formación docente universitaria en Trabajo Social demanda la aplicación de enfoques innovadores en los procesos de enseñanza-aprendizaje, adaptándose a las nuevas estructuras y sistemas sociales, así como a sus proyecciones futuras. La clave no solo reside en impartir conocimientos, sino en preparar a los estudiantes para afrontar los desafíos de la intervención social de manera efectiva. Nos encontramos en un momento oportuno para reflexionar sobre cómo la formación en Trabajo Social puede evolucionar y adaptarse a las demandas cambiantes de la sociedad. La innovación en la metodología educativa se convierte así en un elemento crucial para el desarrollo profesional efectivo de los estudiantes en el presente y el futuro.
Cause-specific mortality in reproductive-age breast cancer patients: A competing risk approach
Authors:   Department of Statistics, Utkal University, Bhubaneswar, Odisha, India., Priyadarshini Subhadra , Panda Kunja Bihari ,   Department of Statistics, Central University of Jharkhand, Ranchi, India.
Published: February 2025

Background: Breast cancer (BC) is a leading cause of mortality among women, particularly those in the reproductive age (15-49 years).

Objective: This study aims to examine the survival outcomes of female BC patients in reproductive age groups using a competing risk approach, with a focus on identifying significant determinants of BC-specific mortality and mortality due to other causes.

Materials and methods: This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database. The analysis included women diagnosed with breast cancer within reproductive age groups. The Cumulative Incidence Function (CIF), cause-specific hazard, and Fine-Gray subdistribution hazard models were employed to estimate the impact of potential determinants on BC-specific and other-cause mortality.

Results: A total of 67063 patients were included in the study. The cumulative incidence of breast cancer-specific mortality and other cause mortality at 5 years was 4.8% and 0.95%, respectively. Age at diagnosis, race, tumor stage, and hormone receptor status were significant predictors of breast cancer-specific mortality. The Fine-Gray model revealed that younger age (15-39 years), advanced tumor stage, and negative hormone receptor status were associated with higher hazards for breast cancer mortality (p<0.05).

Conclusion: The study highlights the importance of using a competing risk model to evaluate the cumulative incidence of prognostic factors in breast cancer patients of reproductive age, especially when competing clinical risks are present. These findings can guide personalized treatment strategies based on individual risk profiles.
Trustworthy AI in Biometrics: A Comprehensive Review of Trends and Challenges
Authors: Arora Shefali , Goel Kanu , Gupta Shikha , Mittal Ruchi , Shrivastava Avinash Kumar
Published: February 2025

Deep Learning (ML) and Artificial Intelligence (AI) are rapidly spreading over many application domains. However, the creation of intelligent systems is constrained by inherent flaws in the learning algorithms that are employed. One major barrier to the application of these techniques is the unpredictable nature of model performance. The reliability of a model is determined by its capacity to remove biases, elucidate findings, and adapt to changes in input data. The idea of trustworthy AI uses a variety of machine learning techniques to explain a model’s decision-making process, hence boosting user confidence in the model’s output. The significance of reliable AI in the context of biometrics is the main topic of this study. Our survey identifies the several types of reliable AI that can be used to increase the dependability of the choices made.
Against the Tide and with the Flow: Water and Urban Masses in Weimar Cinema
Authors: Densky Doreen
Published: February 2025

abstract: This article explores the vital role of water in conjunction with the depiction of urban masses in three Weimar-era films: Metropolis, Berlin. Die Sinfonie der Großstadt , and Menschen am Sonntag . I argue that attention to water, within the range of new materialisms, weaves together the symbolic realm (dreamlike, mythical) and a hydro-material dimension as it relates to contemporary environmental and social critical discourses around metropolitan crowds. Juxtaposing select sequences of these films reveals shared socio-environmental subtexts of modern industrial control as well as aesthetic-representational affinities, which extend to aquatic imagery for describing audience perceptions of movies themselves, the modern mass media.
Motherhood That Is Einfach anders
Authors: Landry Olivia
Published: February 2025

abstract: Nearly a decade ago, a controversial debate raged in Germany under the English-language hashtag #regrettingmotherhood. Set off by a 2015 study conducted by the Israeli sociologist, Orna Donath, this debate hinged on the question of maternal regret: could mothers regret having children? That same year, filmmaker Sheri Hagen released the short film, Einfach anders ( Simply Different ), about a different kind of maternal regret that turns on the unfulfilled desire to be a mother. Without positioning Hagen's film in antagonistic opposition to the phenomenon of regretting motherhood, this essay queries the difference that Blackness introduces to this discourse.
"Ein altes Thema, neu gesehen": Remediating Weimar Modernity in Wolfgang Liebeneiner's Großstadtmelodie (1943)
Authors: Hennessy Mary
Published: February 2025

abstract: This article examines Wolfgang Liebeneiner's popular film Großstadtmelodie (Metropolitan melody). Released in 1943 but set in 1937–1938, the film repurposes Weimar's New Woman and prewar newsreel footage of Berlin to transport audiences, especially women on the home front, to interwar Berlin, not only to distract from the war but also to envision a future Berlin that would be achieved only after the war was won. I suggest that remediation in the film works ultimately to counter the aesthetic, social, and historical fragmentation of war, captured by the feminine "melody" of the film's title and central metaphor.