bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSESSMENT OF THE QUALITY OF CARE FOR PATIENTS WITH MYOCARDIAL INFARCTION
Authors: Ohniev Viktor A. , Podpriadova Anna A. , Pomohaibo Kateryna H.
Published: October 2020

The aim of the work was to study and evaluate the quality of medical care provided to patients with myocardial infarction.
Materials and methods: A sociological survey was conducted in 310 people with myocardial infarction and the copying of data from 318 statistical maps of patients who
left the hospital.
Results: It was defined that the majority of patients, 57.7 ± 2.8%, were not offered psychological rehabilitation, only 42.3 ± 2.8% were recommended the consultation of a
psychologist; most of patients, 89.3±1.78%, were unaware of the possibility of self-monitoring of their health status after myocardial infarction and 10.7 ± 1.8% kept selfcontrol
diaries; 88.4±1.9% of patients were under monitoring supervision, while 11.6 ± 1.9% were not under it.
Conclusions: Identification of the quality of care makes it possible to optimize the system of providing health care for patients with myocardial infarction.
THE CHARACTERIZATION OF HEADACHE IN PATIENTS WITH DYSCIRCULATORY ENCEPHALOPATHY OF DIFFERENT GENESIS
Authors: Litvin Olena V. , Kravchenko Anatolii M. , Klymenko Oleksandr V. , Lytvyn Maksym M. , Klymenko Liliana V.
Published: October 2020

The aim of the study was to study the headache features in patients with dyscirculatory encephalopathy of different genesis.
Materials and methods: Clinical-neurological and clinical-instrumental examination of 90 persons aged 40 to 68 was performed. The first group consisted of 60 patients with
dyscirculatory encephalopathy and arterial hypertension (DE and AH), the second group – 30 patients with dyscirculatory encephalopathy and cerebral atherosclerosis (DE and CA).
Results: In the study of headache in patients with DE + AH and DE + CA, the frequency of detection, the intensity on the VAS scale, and the nature of the headache, no significant
difference was found between study groups.
Conclusions: According to the results of the study, it was proved that patients with DE + CA had headache in the root area, with the circumstances of headache being significantly
outweighed «for no apparent reason» (p = 0.007) and with changing weather conditions (р = 0.001). Arterial hypertension was a major factor in headache (p = 0.008) and
in patients with DE + AH.
RISK FACTORS ASSOCIATED WITH THE OCCURRENCE OF EARLY COMPLICATIONS OF ACUTE MYOCARDIAL INFARCTION AFTER CARDIO-INTERVENTION TREATMENT
Authors: Holovanova Iryna A. , Oksak Grygori A. , Tkachenko Iryna M. , Khorosh Maxim V. , Tovstiak Mariia M. , Strashko Yevhen Yu.
Published: October 2020

The aim of our study was to identify the main risk factors for the occurrence of early complications of acute myocardial infarction after cardio-interventional treatment and to
evaluate prognostic risk indicators.
Materials and methods: Risk factors of myocardial infarction were determined by copying the case history data and calculating on their basis of the odds ratio and ±95%
confidence interval. After it, we made a prediction of the risk of early complications of AMI with cardiovascular intervention by using a Cox regression that took into account the
patient’s transportation time by ambulance.
Results: Thus, the factors that increase the chances of their occurrence were: summer time of year; recurrent myocardial infarction of another specified localization (I122.8);
the relevance of the established STEMI diagnosis; diabetes mellitus; renal pathology; smoking; high rate of BMI.
Factors that reduce the chances of their occurrence: men gender – in 35%; the age over of 70 – by 50%; the timely arrival of an emergency medical team – by 55%. The factors
that increase the chances of their occurrence were: age over 70 years; subsequent myocardial infarction of unspecified site; diabetes mellitus.
Using of a Cox regression analysis, it was proved that the cumulative risk of early complications of AMI with cardio-intervention treatment increased from the 10th minute of
ambulance arrival at place, when ECG diagnosis (STEMI), presence of diabetes mellitus, smoking and high BMI.
Conclusions: As a result of the conducted research, the risk factors for early complications of AIM with cardio-interventional treatment were identified.
PREVALENCE OF COMPLAINTS AND RISK FACTORS IN PATIENTS WHO APPLIED TO THE AMBULATORY OF GENERAL PRACTICE – FAMILY MEDICINE
Authors: Kononov Оlexander Ye. , Klymenko Liliana V. , Protsiuk Olha V. , Klymenko Oleksandr V. , Syniachenko Valentyn V. , Povietkina Tetiana M. , Dobrianskyi Vasyl T. , Mykhalevych Nataliia F. , Dobrianska Mariia B.
Published: October 2020

The aim of our work was to conduct a comprehensive assessment of the frequency and features of patient’s complaints, the prevalence of major vascular risk factors in patients
who applied for medical care to the ambulatory of general practice – family medicine and analysis of the results based on questionnaires using the original questionnaire.
Materials and methods: It was compiled a questionnaire according to which 87 people from 18 to 60 years old, were interviewed who applied to the general practice outpatient
clinic – family medicine. The questionnaire included questions related to the well-being of those who went to the outpatient clinic, questions regarding the lifestyle, nutrition,
bad habits, the specifics of work and the chronic pathology of the respondents and their relatives. First group included 42 (48.3%) middle-aged patients according to WHO
classification, second group – 45 (51.7%) young adults.
Results: With the help of questioning of the patients who went to the outpatient clinic, we identified and statistically confirmed the risks of the occurrence and development
of pathology of arterial hypertension and coronary heart disease. The odds ratio is quite high in persons with memory impairment, attention – 4.41; feeling of heaviness in the
head – 3.45; dizziness – 5.02; heartache – 5.54; overweight – 6.80; not involved in sports – 3.66 in our survey groups.
Conclusions: In this study we have determined the risk groups of patients and the predictors of development of cardio- and cerebrovascular pathology in patients of the first
group are revealed.
STERNAL CLEFT AND SEGMENTAL FACIAL HEMANGIOMAS IN CHILDREN WITH PHACES SYNDROME: EFFECTIVENESS AND SAFETY OF CONSERVATIVE MANAGEMENT AND SURGICAL CORRECTION
Authors: Benzar Iryna M. , Levytskyi Anatolii F. , Pylypko Vlasii M.
Published: October 2020

The aim is to determine the risk factors of sternal cleft and segmental facial hemangiomas association in children with PHACES syndrome.
Materials and methods: 32 inpatient children with segmental facial hemangiomas and 19 children with sternal cleft were investigated concerning the Metry criteria of
PHACES syndrome.
Results: In 6 children PHACE syndrome was diagnosed. Patients with bilateral S3 hemangiomas (50%, 3/6) had airway involvement with respiratory disorders. Conservative
treatment was propranolol monotherapy (66.7%, 4/6), or combination of prednisolone and propranolol (33.3%, 2/6). Duration of propranolol treatment in children with
PHACES syndrome was on an average 24.25 � 4.49 months exceeding the duration of propranolol therapy in children with isolated soft tissue lesions (p<0.05). Primary surgical
treatment of sternal cleft performed in children aged 2 (n=3) and 4 (n=1) months. The later period of surgery associated with the localization of hemangioma in the surgery
region. Primary repair of sternal cleft was completed successfully in all cases; partial resection of the thymus made closure easier.
Conclusions: Primary surgical correction of a sternal cleft performed in young children provides good results. Partial resection of the thymus prevents respiratory and cardiovascular
complications. Preoperative propranolol treatment averts the hemorrhagic complications in children with hemangiomas in surgical region.
ORGANIZATION AND LEGISLATIVE REGULATION OF REHABILITATION ASSISTANCE TO PARTICIPANTS OF JOINT FORCE OPERATIONS
Authors: Zhdan Vyacheslav М. , Havlovskyi Oleksandr D.
Published: October 2020

The aim of our study was to investigate the mechanisms of rehabilitation, primarily medical, of participants in the armed conflict in the eastern regions of Ukraine (anti-terrorist
operation/Joint Forces operation).
Materials and methods: Standard statistical methods were used to accomplish these tasks – bibliosemantic and content analysis methods. So, as can be seen from the
conducted research, in Ukraine there is a legal regulation of the process of providing rehabilitation assistance (social, psychological, medical) for the participants of armed
conflict in the eastern regions of Ukraine (ATO / JFO).
Review: It should be noted separately that the organizational mechanisms for the provision of rehabilitation are constantly improving: introduction of the International Classification
of Functioning, Restrictions of Life and Health and the International Classification of Functioning, Restrictions of Life and Health of Children and Adolescents in Ukraine introduced
the qualification characteristics of rehabilitation specialists and rehabilitation specialists , physical therapist, ergotherapist, physical therapist assistant, ergotherapist assistant.
Conclusions: It was also determined that despite the constant improvement of the organizational and regulatory frameworks for the provision of rehabilitation, there is a problem
of the lack of unified protocols for the provision of medical rehabilitation – there is only a protocol of measures for post-traumatic stress disorder. Available and applicable the
“road map” of providing of medical assistance, reparative treatment and rehabilitation measures in health care facilities for ATO participants.
THE STUDY OF THE ELECTROMAGNETIC COMPONENT OF THE HUMAN BODY AS A DIAGNOSTIC INDICATOR IN THE EXAMINATION OF PATIENTS WITH NON-COMMUNICABLE DISEASES: PROBLEM STATEMENT
Authors: Mintser Ozar P. , Semenets Valery V. , Potiazhenko Maksim М. , Podpruzhnykov Peter М. , Nevoit Ganna V.
Published: October 2020

The aim of the publication is to substantiate a conceptual system of views on the role of internal electromagnetic fields and the scientific feasibility of studying the direction
of their possible use as a diagnostic indicator in the examination of patients with NCDs.
Materials and methods: The of the presented data was carried out during a search study of methods for the rapid assessment of valeological status, prenosological early
diagnosis of NCDs, analysis of existing methods for studying the electromagnetic phenomena of the human body.
Review: The authors systematized the existing technical capabilities and instrumental methods in the framework of systemic medicine. The article proposes a working
classification of methods, justifies the choice of methods for further research.
Conclusions: 1) The study of the electromagnetic component of the human body as a diagnostic indicator in the examination of patients with NCDs is a relevant and promising
scientific direction at the present stage. 2) Methods for assessing heart rate variability in a short recording, computerized hardware segmental diagnostics, a computerized digital
study of Gas-discharge Electrophotonic Analysis, determination of the PBS-activity of body tissues were selected to further examine the value of their diagnostic parameters in
examining patients with NCDs in the first and second levels of therapeutic care.
ORGANIZATIONAL, REGULATORY AND LEGAL ASPECTS
OF EUROPEAN INTEGRATION OF HIGHER MEDICAL EDUCATION
IN UKRAINE: A CRITICAL REVIEW
Authors: Marichereda Valeria G. , Melnyk Svіtlana B. , Borshch Viktoriia I. , Terzi Olena O. , Lyakhova Natalia A.
Published: October 2020

The aim: The main purpose of this research is to conduct the theoretical and applied study of the legal profile enforcement for state attestation of medical graduates, the relevant
legislative system, and its effectiveness; to identify the issues of special legislative requirements, as well as the search for ways to resolve it.
Materials and methods: Basic methods: analysis, synthesis and comparison. Object of research: system of state certification of graduates of medical sciences. Investigation
of this topic in the paper is carried out in the following logical sequence: firstly, the basic principles of the state integrated qualification exam were determined and analyzed;
then the legal enforcement for integrated state qualification exam of master’s degree in discipline “22 Health Care” was considered. Also, a critical review of Ukrainian normative
base for holding the state attestation of medical graduates was conducted.
Conclusions: In view of foregoing, we can make a conclusion that in the modern globalization world, competition of national educational services should be ensured by a range
of different activities: legal, organizational, financial, etc. The legal direction, domestic rules should correspond to similar, uniform rules and practices of the most effective state
(regional, international) systems.
АNALYSIS OF MORBIDITY AND DISABILITY AMONG CHILDREN
IN THE CITY OF POLTAVA
Authors: Bielikova Inna V. , Pluzhnikova Tatiana V. , Krasnova Oksana I. , Zviagolska Iryna N. , Derev'yanko Tetyana V.
Published: October 2020

The aim: analyze the morbidity and causes of disability among children of Poltava.
Materials and methods: medical and statistical – for the collection, processing and analysis of data (descriptive and analytical statistics to determine relative indicators, absolute
growth indicators), a systems approach and system analysis. The work uses materials from the State Statistics Service of Ukraine, as well as data from children’s hospitals of Poltava.
Review: In recent decades, the morbidity and prevalence of diseases of children`s of Ukraine remained as high. In the Poltava region, the basis of medical work on the sector
includes the principles of early access to medical care, early diagnosis, timely examination and adequate treatment. Оver the past five years, there is a decrease in the number of
newborns who visited outpatient hospitals. In the structure of causes of childhood disability over the past 5 years, the first three places are occupied by congenital malformations,
diseases of the nervous system and diseases of the endocrine system. Moreover, children’s disability from diseases of the nervous and endocrine systems is constantly growing.
Conclusions: One way to improve the health care system for children is to optimize it. It is aimed at improving preventive work, preserving and restoring the health of the child
population, improving and updating medical institutions, and increasing the level of professionalism of medical workers.
STRUCTURAL REORGANIZATION OF THE RATS’ SUBMANDIBULAR GLANDS ACINI AFTER THE INFLUENCE OF 1% METHACRYLATE
Authors: Yeroshenko Galyna А. Yeroshenko , Fedoniuk Larysa Ya. , Shevchenko Konstantyn V. , Kramarenko Denys R. , Yachmin Аnastasiia І. , Vilkhova Olena V. , Skotarenko Tetiana A.
Published: October 2020

Introduction: Polymeric substances, which are used in medicine, can lead to the development of pathological conditions. Therefore, in toxicological evaluation of polymeric materials for medical purposes the primary task is the creation of the appropriate adequate methods of study. The aim: To study the acini of the rats’ submandibular salivary glands in normal condition and after exposure of 1% methacrylate. Material and methods: Were studied 50 white rats during the influence of 1% methacrylate on the mucosa of the oral cavity. Histological sections of the rats’ submandibular salivary glands in normal condition, on day 14 and 30 of experiment were studied using the UMPT – 7 ultramicrotome of Sumy PA “Selmi”. Results and conclusions: The morphometric study has established that in control group the values of the outer diameter of the submandibular glands’ acini, the diameter of the lumen and the height of the acini epithelial cells was 36,27±2,17 μm, 9,47±0,63 μm and 14,18±1,05 μm, respectively. Histological specimens showed that the acini cells had a prominent basophilia of the cytoplasm and the basally located nucleus. Numerous large homogeneous granules were located in the apical pole of the cells. After influence of the 1% methacrylat there is an increase in the activity of secretory cells, which is confirmed by an increase in the height of epitheliocytes by 25.04% and is a compensatory metacrylate reaction. The increase in salivation further leads to complete depletion of the secretory apparatus of the seromucosal cells, which is confirmed by a decrease in the outer and inner diameters with a decrease in the height of the mandibular salivary glands acini cells by 24.40%.
INFLUENCE OF TWO-HOUR TOURNIQUETS ISCHEMIA OF LIMB AND ACUTE BLOOD LOSS ON SYSTEMIC DISORDERS OF THE BODY IN THE REPERFUSION PERIOD (EXPERIMENTAL STUDY)
Authors: Horban Ivanna I. , Hudyma Arsen A. , Maksymiv Roman V. , Antonyshyn Iryna V.
Published: October 2020

The aim: to find out the effect of a two-hour tourniquets ischemia of the limb and acute blood loss on systemic disorders of the body in the postperfusion period.
Materials and methods: The experiments were performed on 96 nonlinear male rats weighing 200-220 g. All experiments were performed under sodium thiopental anesthesia.
In the first experimental group, two-hour tourniquets limb ischemia was simulated. In the second experimental group, acute blood loss was modeled. In the third experimental
group, these lesions were combined. In 1 and 2 hours, as well as in 1, 7 and 14 days, the biliary function of the liver was determined in the experimental animals.
Results: Two-hour tourniquets ischemia of the limb in the reperfusion period compared with the control was accompanied by a significant decrease in the rate of bile excretion,
which reached a minimum value in 3 h – 1 day of the experiment and returned to the control level in 14 days. After the simulation of acute blood loss, the rate disturbance of
bile excretion became significantly greater in all observation periods. The complication of acute ischemia-limb reperfusion caused a greater decrease in the rate of bile excretion
with a maximum in 1 day of the experiment. Under these conditions, at 1, 7, and 14 days, the indicator was statistically significantly lower than in the other study groups.
Conclusions: In the case of acute blood loss, complicated by two-hour tourniquets ischemia of the limb, the reperfusion period is accompanied by a summation of the negative
impact of blood loss, ischemia and reperfusion of the limb on the functional state of the liver, which is a significant decrease in the rate of bile excretion with a maximum in 1
day, which further increases, but up to 14 days does not reach the level of control.
MATERNAL PSYCHOSOCIAL STRESS AND LABOR DYSTOCIA
Authors: Zhuk Svitlana I. , Shchurevska Oksana D.
Published: October 2020

The aim: to study the possible role of psychosocial stressors in the emergence of anomalies of childbirth, as well as to examine their nature using the example of pregnant women who have been forcefully displaced from Donetsk and Luhansk regions of Ukraine. Materials and methods: 115 internally displaced pregnant women from Donetsk and Luhansk regions, were surveyed. All women underwent a comprehensive neuropsychological examination of their psycho-emotional status via interviews, questioning, and psychological testing (Spielberg-Haning’s Situational and Personal Anxiety Scale). The following analysis of the childbirth process’ nature was conducted. Results: The prevalence of high level of situational and personal anxiety by the Spielberg-Haning’s test were determined in the internally displaced women. This indicates a high level of social anxiety (stress) in these pregnant women. Labours in women in this group can be characterized by 3 main features: rapid (precipitated) labour with high levels of obstetric traumatism (tear of perineum) and labour medicalization (EDA). The characteristics described above are due to such labour activity anomalies as hypertensive uterine dysfunction – the cases when the speed and strength of uterine contractions significantly exceed the normative parameters. The reasons for the high level of pain in labour in displaced women could be objective and subjective factors: excessive nociceptor irritation due to cervical-uterine dysfunction and impaired individual perception of pain. Conclusions: Chronic psychosocial stress has an impact on labour activity in displaced women. A mandatory standard for managing such pregnancy is psychological counselling and correction of the identified disorders.
PAIN RELIEF DURING LABOR – WHAT DO WE KNOW AND WHAT SHOULD WE KNOW? RESEARCH BASED ON THE STUDENT POPULATION IN WARSAW
Authors: Rozek Martyna , Smiech Zuzann , Kolacz Marcin , Kosson Dariusz
Published: October 2020

The aim: Women of reproductive age often think of motherhood and labor with fear of intense labor pain. The anxiety they experience can lead to their postponing pregnancy. There are not many studies in the literature that research the knowledge young women have about the analgesia of labor. The aim of the present work was to evaluate the state of awareness about the possible methods of labor analgesia among women of childbearing age. Material and methods: An Internet survey was conducted among 160 women. It consisted of questions on the pharmacological and non-pharmacological methods of labor analgesia. Most of the respondents were not medical university students (96.2%). Correct answers ranged between 11.3% and 97.5% of the total responses. Results: The greatest number of incorrect answers were given to the question regarding contraindications to labor anesthesia (only 11.3% of answers were correct). There was also a low percentage of correct answers to questions about the risk of spinal cord injury during the procedure of inducing anesthesia (18.8% of correct answers), the motor activity of a woman after analgesia (22.5%) and the reimbursement of anesthesia (29.4%). Nearly 40% of the respondents did not know the correct answer to the question about the possibility of breastfeeding after anesthesia. The problem of aalgesia during twin delivery also posed a challenge. Over half of the respondents (54.1%) incorrectly answered the question about the occurrence of complications among women who want to become pregnant again after the procedure of labor anesthesia. Moreover, 70.6% of the women surveyed considered non-pharmacological methods of labor anesthesia to be safer compared to pharmacological analgesia. The most commonly mentioned methods of non-pharmacological labor pain relief included breathing techniques and water birth. Conclusions: The study shows that women
ANALYSIS OF СYTOCERATINE 19 EXPRESSION LEVEL BY
IMMUNOCYTOCHEMICAL DIAGNOSTIC METHOD IN LARYNGEAL
CANCER PATIENTS WITH REGIONAL METASTASES
Authors: Kovtunenko Oleksander V. , Shportko Bohdan V. , Tymchuk Serhey M.
Published: October 2020

The aim: To investigate the informative content of immunocytochemical studies of lymph node aspirate using a molecular marker of cytokeratin 19 in patients with laryngeal
cancer as for regional metastastatic spread.
Materials and methods: A comprehensive investigation with immunohistochemical study of squamous cell carcinoma of larynx of 74 patients with laryngeal cancer II – IV
stage (T2-4 N0-3 M0) of the second clinical group was conducted.
Results: Statistically significant differences (p <0.001) in the structure of distribution of marker expression between groups were revealed. Thus, a marked expression of
cytokeratin 19 was determined in 11 (29.73%) representatives of the group with regional metastases and only in 1 (2.7%) patient without tumor metastases (p = 0.002). In
the group with metastases the presence of atypical cells was confirmed cytologically in 26 cases (70,27%).
Conclusions: To predict the development of laryngeal metastases in laryngeal cancer patients, it is recommended to carry out an immunocytochemical study using a diagnostic
marker of cytokeratin 19. The positive status of cytokeratin 19 increases the chances of regional metastasis of laryngeal cancer by 18.37 times (p<0.001) compared with absence
of expression.
MECHANISMS OF INSOMNIA FORMATION WITH GASTROESOPHAGEAL
REFLUX DISEASE, TAKING INTO ACCOUNT THE PSYCHOSOMATIC
STATUS IN YOUNG PEOPLE
Authors: Oparin Aleksey A. , Balaklytska Iryna O. , Morozova Olga G. , Oparin Anatolii G. , Khomenko Ludmila O.
Published: October 2020

The aim: The work is aimed to study the formation mechanisms of sleep disturbances with GERD based on the determination of melatonin and serotonin indicators in the blood,
psychosomatic status and quality of sleep, motor-secretory function of the esophagus and stomach in young people.
Materials and methods: All 63 patients were with non-erosive GERD and insomnia. Among them, 32 with inhibitory personality type and 31 with excitable personality
type. The control group is 25 people. Questionnaires were used to determine the quality of sleep, quality of life, state of the nervous system, ultrasound, stomach acidity, level
of melatonin and serotonin.
Results: In patients with inhibitory personality type, depressive disorders, lower sleep quality and quality of life were more pronounced, and in patients with excitable type,
increased levels of reactive and personal anxiety and pronounced motor-secretory disorders.
Conclusions: Psychosomatic disorders in GERD have a significant impact not only on the quality of sleep, quality of life, the level of melatonin and serotonin, the regulation of
the secretory and motor functions of the stomach, but they are one of the links in the pathogenetic mechanism of the formation of both GERD and insomnia with it.
PROCALCITONIN IN EARLY PREDICTION OF ACUTE SEVERE
PANCREATITIS
Authors: Kasian Volodymyr V. , Sheiko Volodymyr D. , Mamontova Tetiana V. , Vesnina Liudmyla E. , Shlykova Oksana A.
Published: October 2020

The aim of the study was to analyze the prognostic potential of procalcitonin in acute pancreatitis complicated by ascites-peritonitis.
Materials and methods: The study analyzed the results of a comprehensive examination and treatment of 18 patients with acute pancreatitis complicated by enzymatic
ascites-peritonitis, including 13 patients who were treated in the surgical department of KP “Poltava Regional Clinical Hospital. MV Sklifosovsky POR “, and 5 patients of other
emergency hospitals in Poltava, in the period from 2017 to 2019. In addition to standard screening methods, these patients were additionally tested for procalcitonin to predict
an adverse course in the early period.
Results: To assess the relationship between the presence of elevated procalcitonin levels at the time of hospitalization of 0.5 ng / ml and above and unsatisfactory treatment results,
differences were assessed using an accurate Fisher test. When comparing differences in the development of infectious complications in the dynamics of the disease in patients of
the study group depending on the presence of elevated concentrations of procalcitonin or its absence at the time of hospitalization, a significant difference was found (p <0.05).
Conclusions: In our opinion, the use of procalcitonin as a predictor of infectious complications in the dynamics of the disease will determine the category of patients in whom
reducing the risk of flora translocation through the use of early oral antibiotic prophylaxis and parenteral drugs tropic to pancreatic tissue may reduce the incidence of purulent
complications. In another category of patients, antibacterial therapy is not advisable due to the low risk of purulent-septic complications.
KEY WORDS: acute pancreatitis, procalcitonin, ascites-peritonitis, severity of the condition
CLINICAL USEFULNESS OF THE INTERNATIONAL RENAL
RESEARCH INSTITUTE OF VICENZA (IRRIV) SCORE IN THE
INTENSIVE CARE SUBJECTS WITH RENAL FAILURE:
SINGLE-CENTRE EXPERIENCE
Authors: Wiorek Agnieszka , Horodecka Milena , Krzych Lukasz J.
Published: October 2020

The aim: Acute kidney injury (AKI) is a common and clinically important condition that affects both kidney structure and function. International Renal Research Institute of
Vicenza (IRRIV) score has been designed to enable early identification of patients who may require renal replacement therapy (RRT). We aimed to assess the usefulness of the
IRRIV score in predicting the outcome in the intensive care unit (ICU) patients who may require renal replacement therapy (RRT).
Material and Methods: This retrospective study screened 955 consecutive patients hospitalized in a mixed tertiary ICU between Jan 2015 and Jul 2018. Patients with sCr>3.5 mg/dl on the first 24 hours post-admission constituted the study group 1 (G1, n=54). Subjects who underwent RRT based on indications other than elevated sCr level were a study group 2 (G2, n=31). ICU mortality, a need for RRT and ICU length of stay (LoS) were the outcomes.
Results: Median IRRIV score was 5.5 points (IQR 4.5-6.5) in G1 and 3.5 points (IQR 3-5.5) in G2. IRRIV score poorly predicted the need for RRT implementation (AUC=0.652,
95%CI 0.510-0.776, P=0.048). The IRRIV score failed to predict mortality in both groups (G1: AUC=0.610, 95%CI 0.468-0.740, P=0.16; G2: AUC=0.530, 95%CI 0.343-0.710,
P=0.79). No correlation was found between the score and ICU LoS (G1: R= -0.13, P=0.36; G2: R= -0.27, P=0.15).
Conclusions: The retrospective analysis of our regional data did not confirm the expected usefulness of the IRRIV score in predicting the need for RRT nor in the prognostication
of the patients admitted to the ICU due to renal failure.
THE EFFECT OF BETA-BLOCKERS ON A COURSE OF CHRONIC HEART FAILURE IN PATIENTS WITH A LOW TRIIODOTHYRONINE SYNDROME
Authors: Pyvovar Sergiy M. , Rudyk Iurii S. , Kopytsya Mykola P. , Lozyk Tetiana V. , Galchinskaya Valentina Ir. , Chenchik Tetiana O.
Published: October 2020

The aim: The aim is to study the effect of β-ABs in patients with LT3S on the course of HF. Materials and methods: 354 patients with HF on a background of post-infarction cardiosclerosis were included in the 2-yeared follow-up study. LT3S was diagnosed at 89 (25.1%) patients. The levels of thyroid-stimulating hormone, free T3f and T4f, and reversible T3 were determined. The echocardioscopy was performed. Results: Patients with HF in combination with LT3S have a heavier functional class by NYHA, greater dilatation of the left heart cavities, less myocardial contractility, a higher frequency of atrial fibrillation and re-hospitalization. The use of β-ABs in patients with HF without LT3S leads to a likely decrease in hospitalization frequency, while in patients with LT3S it has an opposite effect. The frequency of rehospitalization increases with an excess of β-ABs dose > 5 mg (equivalent to bisoprolol). At these patients a decrease in serum T3 level and negative dynamics of parameters of intracardiac hemodynamics are observed. Conclusions: The use of β-ABs in patients with LT3S leads to an increase in re-hospitalization at a dose over 5.0 mg (equivalent to bisoprolol). In these patients there is a decrease in serum T3, an increase in T4 level; and the ejection fraction decrease; and heart cavities size increase.
SOME CLINICAL AND EPIDEMIOLOGICAL FEATURES
OF INFLUENZA-ASSOCIATED PNEUMONIA DEPENDING
ON THE ETIOLOGICAL AGENT
Authors: Bodnar Vadym A. , Koval Tetiana I. , Pryimenko Nataliia O. , Dubyns’ka Galyna M. , Kotelevska Tetiana M. , Lymarenko Nina P. , Syzova Liudmyla M. , Bodnar Lesia A.
Published: October 2020

The aim: To analyze the epidemiological data and clinical course of pneumonia as a complication of influenza in the Poltava region, depending on the etiological agent.
Materials and methods: We have analysed the data of the official reporting documentation provided by the State Institution “Poltava Regional Laboratory Center of the
Ministry of Health of Ukraine” and the chart of patients with a laboratory confirmed diagnosis of influenza who were in inpatient treatment at the Poltava Regional Clinical
Infectious Hospital (PRCIH) in 2016-2018 years. In more detail, we examined 95 patients with pneumonia, which complicated the course of the flu. There were 43 (45.26%)
female patients, − 52 (54.74%) male patients, aged 18 to 80 years.
Results: Studies have shown that despite a decrease in the incidence of influenza in recent years, the incidence of pneumonia, which complicated the course of the flu, remained
consistently high (19.7% – 20.8%) with bacteriological isolation of S.pneumoniae (22.11%), S.aureus (13.68%), Haemophilus influenza (4.21%) and E.coli (3.16%). Severe course
of pneumonia with bloody sputum, evident shortness of breath, bilateral lung damage, and need for oxygen support were significantly more frequently reported in patients
with isolated S.pneumoniae and S.aureus. However, the severe course of the disease with the formation of abscesses in the lungs was observed only in the group S.aureus despite
the relatively young age of such patients and significantly fewer risk factors for severe influenza and comorbidities.
Conclusions: The study showed a consistently high incidence of pneumonia, which complicated the flu and caused by S.pneumoniae, S.aureus, Haemophilus influenza and
E.coli. Pneumonia caused by S.pneumoniae and S.aureus, were characterized the most severe course; however, a severe course with the formation of abscesses in the lung tissue
was observed only in the group of S.aureus.
KEY WORDS: influenza-associated pneumonia, etiological structure, risk factors, clinical features
EFFECT OF USING THE NIGHTSCOUT SYSTEM ON METABOLIC
CONTROL, SAFETY, AND INCIDENCE OF COMPLICATIONS IN
PATIENTS WITH DIABETES MELLITUS
Authors: Kublin Oskar , Stępień Mariusz
Published: October 2020

Introduction: The Nightscout system is a free Do It Yourself solution. This system appeared in Poland in 2016. The concept of the project is to provide insight into measurements
from the system of continuous glucose monitoring in interstitial fluid by authorized persons.
The aim: The study was carried out to assess the functionality of the Nightscout system and its effect on metabolic control, safety and the incidence of complications in patients
with type 1 diabetes mellitus.
Material and methods:The study comprised 98 patients with type 1 diabetes. The study was conducted online using an anonymous questionnaire targeted at members of
the “Nightscout Polska (Poland)” group on the Facebook.
Results: Severe hypoglycaemic episodes with loss of consciousness were more frequent before using the Nightscout system and were reported by 3 adults (1-2 episodes). No
severe hypoglycaemic episodes were reported when using the Nightscout system. The number of ketoacidosis episodes was reduced from 5 before using the Nightscout system
to 2 episodes during the use of the system in children, and from 3 to 0 episodes in adults. Levels of glycated haemoglobin were lower in patients using the Nightscout system,
both compared to control groups and values before the use it. In people using the Nightscout system glycated hemoglobin values were lower than their values before using this
system. It was also shown that people using the Nightscout system had lower glycated hemoglobin than people from the control group.
Conclusions: Using the Nightscout system can positively affect the safety of insulin therapy and the treatment process of type 1 diabetes. The Nightscout system can be an
improvement of the system of continuous glucose monitoring in interstitial fluid.
THERAPEUTIC PLASMAPHERESIS IN A COMPLEX TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS
Authors: Lyubchak Vladislav V. , Plaksa Viktoriia M. , Pelo Ihor M. , Kovalishyn Michael P. , Lyubchak Viktor P. , Horokh Vladimir V. , Lisovenko Tetyana Iu. , Ilyina Viktoriia V. , Khomenko Liliya M.
Published: October 2020

The aim: To determine the pathogenetic expediency, efficiency and the place of therapeutic plasmapheresis in a complex treatment of patients with chronic hepatitis. Materials and methods: It was carried out the analysis of case histories of 77 patients. In the course of treatment, the patients were diagnosed with chronic toxic hepatitis (K.71). Diagnosis was exposed in accordance with the official documentation introduced by the Gastroenterological department of Sumy Regional Clinical Hospital CH”SRCH”, Sumy Regional Infectious Diseases Clinical Hospital named after Krasovytsky ZY and Sumy Regional Center of Blood Service. Results: It was found that total protein indicator is the normal range and albumin after plasmapheresis and during conservative treatment. Markers of cytolysis and cholestasis are have great value may. The most significant changes were observed in rates indicating lesion of the hepatic parenchyma, including ALT, AsAT and alkaline phosphatase. In conservative treatment, the percentage of the alkaline phosphatase level improved by 31%, after the course of plasmapheresis – by 58%. The obtained figures of cholestasis indexes indicate the effectiveness of both methods of treatment, but treatment with plasmapheresis has a more expressed effect on the decrease of alkaline phosphatase level. The level of bilirubin improve on 38,8% after plasmapheresis and 65% in the comparison group. Conclusion: Inclusion in the complex therapy of chronic hepatitis plasmapheresis reduces the severity of cytolysis and cholestasis, increases remission and significantly improves clinical manifestations.
AGE AND GENDER FEATURES OF DEPRESSIVE AND ANXIETY
SYMPTOMATICS OF DEPRESSIVE DISORDERS
Authors: Belov Oleksandr O. , Pshuk Nataliya G.
Published: October 2020

The aim: of the study is to study the features of the clinical phenomenology of depressive disorders at the present stage, taking into account gender and age factors.
Materials and methods: Clinically examined 107 men and 138 women with bipolar affective disorder (current episode of depression), depressive episode and recurrent
depressive disorder using HDRS, HARS, BDI, C. Spilberger’s Scale of Reactive and Personality Anxiety.
Results: In all patients showed an increase in the severity of depression and anxiety with age, but in women the greatest differences were found between the middle and older
age groups, and in men when comparing young and middle age groups. In young patients the level of agitated depression is higher for men, and women showed the higher
overall level of anxiety, somatic anxiety, undifferentiated depression, reactive and personality anxiety. In patients aged 30-44, men have a significantly higher overall score of
HARS depression, the level of adynamic, agitated and undifferentiated depression, the level of depression on BDI. In the older age group, the levels of depression in men and
women are not significantly different, and the levels of mental anxiety and personality anxiety in women are significantly higher.
Conclusions: The general tendency consisting in increasing the severity of depression with age, and more pronounced indicators of depression in men, and anxiety in women.
In men, the greatest increase in the severity of depression occurs before the age of 44 years, and in women after 45 years.
A NEW PERSPECTIVE ON BRONCHIAL ASTHMA AND CHRONIC
OBSTRUCTIVE PULMONARY DISEASE OVERLAP: POTENTIAL
DIAGNOSTIC CRITERIA
Authors: Pertseva Tetyana O. , Konopkina Lyudmyla I. , Babenko Alina O.
Published: October 2020

The aim: The aim of the research was to analyze the results of observation and examination of COPD patients in order to identify a group of individuals with potential asthma overlap.
Materials and methods: We have conducted a two-stage dynamic investigation of 43 COPD patients during 3–8 years. The patients were divided into two groups: group 1
counted 30 individuals who presented with at least one episode of reversible bronchial obstruction (RBO) during the observation; group 2 – 13 individuals who presented with
nonreversible bronchial obstruction (nonRBO). At the first stage, we conducted a clinical observations analysis and studied lung function examination records; at the second
stage, we calculated the markers of allergic inflammation.
Results: It was revealed that around 70% of COPD patients have occasional episodes of RBO. It was established that the level of blood eosinophils in these patients on the
whole is rather low even in people with intermittent RBO, and the total IgE level appeared to be significantly higher in patients with intermittent RBO comparing to the level
of this marker in patients who have nonRBO.
Conclusions: COPD patients with intermittent RBO and high level of total IgE level form a group with potential asthma overlap.
STUDY OF ANTI-VIRUS ACTIONS OF METABOLITES OF
LACTOBACTERIA
Authors: Kalinichenko Svetlana V. , Melentyevа Kristina V. , Manee Hans , Dubinina Natalia V. , Zvereva Natalia V. , Toryanik Inna I. , Popova Natalia G. , Pakhomov Oleksandr V.
Published: October 2020

The aim: of the work was to study the antiviral activity of the metabolites of the probiotic strain Lactobacillus rhamnosus GG (LGG or ATCC 53103) regarding clinical strains of
enteroviruses (Coxsackie B-5, ECNO21) isolated from the feces of intestinal infections.
Materials and methods: The object of the study was substrate-dependent cell cultures of HeLa, Vero, Hep-2 lines. The titer of the virus was determined by the presence of a
clear cytopathic action (CPA) in the monolayer infected cells of the virus.
Results: Determination of the enteric virus infections activity in the culture fluid showed that in samples with the LGG metabolites, the infections activity of the clinical strains
of enteroviruses decreased after 24 hours, at 1.5-1.7 (p <0.05) times, and after 96 hours in 3, 6 – 5,7 times (p <0,01). the processing of cell cultures by metabolites in the
amount of 0.3 mg / ml contributed to a decrease in the titer of viruses by 2.77 ± 0.11 lg TCDD50 / cm3, 2.83 ± 0.11 lg TCD50 / cm3 and 2.94 ± 0.13 lg TCD50 / cm3 for Vero,
HeLa and Hep-2 line cells in 24 hours.
Conclusions: It has been experimentally determined that the maximum tolerated dose (MTD) of L. rhamnosus GG metabolites was 0.3 μg / ml for all cultures of cell lines.
Determination of the antiviral activity of L. rhamnosus GG metabolites in clinical viruses of enteroviruses (Coxsackie B-5 and ECNO-21) showed a decrease in infection activity
in 1.5-1.7 times, (p <0.05) of clinical trials in clinical trials enteroviruses.
SPECIAL ASPECTS OF THE EFFICIENT DAILY ROUTINE
OF STUDENTS AT MODERN EDUCATIONAL ESTABLISHMENTS
OF DIFFERENT TYPES
Authors: Tymoshchuk Oksana V. , Zhurakivska Oksana Y. , Derpak Volodymyr V. , Kostitska Iryna O. , Tokar Iryna T.
Published: October 2020

The aim of study is special aspects of the efficient daily routine of students at modern educational institutions of different types, and its influence on psychophysical functions,
adaptive abilities, the quality of life as well as the state of mental and somatic health of the youngsters.
Materials and methods: While studying special aspects of the daily routine of students at modern educational institutions and their influence on the state of physical and
mental health, the young people were observed in five modern educational establishments in Ivano-Frankivsk: Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk
Finance Commercial Cooperative College named after S.Granat, Ivano-Frankivsk music school named after Denis Sichinskiy, Ivano-Frankivsk Vocational Motor Transport and
Construction Lyceum № 15, Ivano-Frankivsk boarding lyceum for gifted young people from rural areas. 300 students were observed (150 female students and 150 male students).
The study analyzed their educational conditions, daily routine tension, and activities during breaks, special aspects of leisure arrangements, amount of time spent on homework,
subjective assessment of the level of tension of the educational process, and their projected influence on the health state of students by using static models.
Results: Received results of the assessment of sanitary and hygienic conditions under which training takes place at modern educational institutions of different types, as well as
conditions of after school activities of the students, by applying common methods to evaluate illumination level, microclimate, and air quality have revealed that the youngsters’
conditions at modern educational institutions are marked by absence of significant deviations from common hygienic requirements, they are similar and easily comparable and
that enables defensibly and illuminatively to identify main features of influence of the different psychohygienic methods on the development of health maintaining tools and
the establishment of features of the formation of functional capabilities and the basic correlates of mental and physical health.
Conclusions: The educational conditions of young people in modern educational establishments can be described as not having considerable deviations from common hygienic
requirements, being easily comparable and enabling to identify main influence factors of different types of psychohygienic methods of developing and implementing of healthmaintaining
tools on the course of formation of the functional capabilities of the body and the development of the main adaptation reactions in young males and females.
IMPACT OF PANDEMIC COVID-19 ON THE LEGAL REGULATION OF
WORLD TRADE ACTIVITY USING THE EXAMPLE OF THE MEDICAL
SUPPLIES
Authors: Alazzam Farouq Ahmad Faleh , Saleh Ali Jabbar , Aldrou Khaled Khalaf Abed Rabbo
Published: October 2020

The aim of the article is a theoretical and methodological justification for strengthening the role of international trade in medicines and equipment during the COVID-19
pandemic, to establish the benefits of free trade, to develop important international trade policy priorities in this field.
Materials and methods: Legislation of foreign countries and international organizations, statistical data published by international organizations are the materials of the
research. Methods of analysis, synthesis, generalization were applied during the research.
Conclusions: It has been proved that the legal regulation of world trade activity by medical supplies are increasingly playing more important roles in the implementation of
international development goals. The authors have offered three priorities to all countries: to cooperate globally around the deployment of life-saving medical supplies, publicly
commit all countries not to implement export bans or limits on relevant medical supplies; to control all trade measures countries have taken in response to the COVID-19 outbreak;
to bring together in a global form measures and procedures to eliminate this phenomenon.
MEDICAL AND PROCEDURAL-LEGAL ASPECTS OF INPATIENT
AND OUTPATIENT FORENSIC PSYCHIATRIC EXAMINATION
Authors: Kaija Sandra , Kudeikina Inga , Gutorova Nataliya
Published: October 2020

The aim: The aim of the study is to define the legal framework of forensic psychiatric examination commissioned by the court in relation to the competence of medical practitioners
and the position of the subject as a patient in the process of forensic psychiatric examination in order to determine the correlation of special legal regulation with criminal and
civil procedure regulation and to make proposals for the enhancement of the legal regulation.
Materials and methods: This study is based on the analysis of international law, medical civil procedure and criminal procedure legislation, juridical practice, medical law
legal doctrine. The following methods were used in this research: the method of interpretation of legal norms, analysis of legal acts, and the induction-deduction method, upon
which the conclusions were drawn and recommendations were provided.
Conclusion: The current regulatory framework does not provide for the procedure by which the subject’s medical treatment is conducted during forensic psychiatric examination,
nor does it determine the criteria for the admissibility of treatment of the persons concerned and the extent of treatment. During the examination, the medical practitioner who
is in the expert’s procedural position in relation to the subject under examination in the particular examination should not carry out the treatment of the subject.