bluuebunny/crossref_metadata_2025 huggingface dataset:
A phase 1 study of IO102-IO103 vaccine plus pembrolizumab in patients with BCG-intolerant or unresponsive non-muscle invasive bladder cancer (NMIBC).
Authors: Veeravelli Sumana , Dall'era Marc , Gulati Shuchi , Mitsiades Nicholas , Verma Rashmi , Evans Christopher P. , Chandrasekar Thenappan , Monjazeb Arta Monir , Lara Primo N , Parikh Mamta
Published: January 2024

TPS716

Background: Pembrolizumab, an anti-PD1 antibody, is a treatment option for high-risk BCG-unresponsive NMIBC, but has a modest complete response (CR) rate of 41% at 3 months, and a median duration of CR of 16.2 months. IO102-IO103 is a novel immune-modulating cancer vaccine that stimulates activation of T cells targeting indoleamine-2,3-dioxygenase 1 (IDO1) and PDL1-positive cells, resulting in potentially increased susceptibility to anti-PD-1 blockade. Combination IO102-IO103 with nivolumab showed encouraging clinical activity and tolerability in previously anti-PD-1 naïve metastatic melanoma patients (NCT03047928). The existing data for synergistic effects of IO102-IO103 in combination with anti-PD1 therapy and the known expression of IDO in urothelial carcinoma lend rationale to this phase I trial designed to assess the feasibility, safety, and toxicity of IO102-IO103 plus pembrolizumab in patients with BCG-intolerant or unresponsive NMIBC. Methods: This open-label, single arm, phase 1 study enrolls patients with BCG-unresponsive or intolerant high-risk NMIBC who are ineligible for or have declined cystectomy and have adequate ECOG performance status (0-2), hematologic function, and end organ function. High-risk NMIBC is defined as T1, high-grade Ta, or CIS/Tis, with predominantly urothelial cell histology. Exclusion criteria include known active autoimmune disorders requiring immunosuppressive therapy or prior checkpoint inhibitor therapy. Eligible patients will be treated with pembrolizumab 200 mg IV on Day (D) 1, and IO102-IO103 85 mcg SQ on D1 and 8 of a 21-day cycle for the first two cycles, after which IO102-IO103 dosing will be D1 only, with treatment for up to 2 years. The primary endpoints of feasibility, safety, and toxicity will be evaluated by CTCAE v5.0 criteria and will be met if ≥10 patients out of 12 are able to complete the first cycle without experiencing pre-specified treatment-limiting toxicities. Key secondary endpoints include CR rate at 3 months, median duration of response, and cystectomy-free survival at 18 months. Biopsy specimens and serial urine and blood samples will be collected to evaluate potential biomarkers of response. Clinical trial information: NCT05843448 .
WUTSUP-02-II-Neo-Dis-Tis: Investigating the efficacy and safety of neoadjuvant tislelizumab plus disitamab vedotin with adjuvant tislelizumab in upper urinary tract carcinoma—A phase II multi-center study.
Authors: Bao Yige , Liao Xinyang , Zhang Peng , Zeng Hao , Liu Jiyan , Wei Qiang
Published: January 2024

TPS718

Background: Upper tract urothelial carcinoma (UTUC) and urothelial bladder cancer (UBC) are frequently referred to as “disparate twins” despite their common tissue origin. They exhibit varying biological behaviors, prognostic outcomes, and responses to treatment. It is crucial to conduct dedicated clinical trials for UTUC as a separate entity rather than relying solely on UBC study results, giving that UTUC lags in evidence quantity and quality compared to UBC. Despite the superior outcomes of neoadjuvant treatment over adjuvant treatment in UBC trials, the currently available evidence for neoadjuvant therapy of UTUC remains limited in quantity and diversity, as the largest trial, POUT, is focused on adjuvant therapy. Additionally, the limited number of neoadjuvant trials for UTUC primarily utilize chemotherapy-based regimens, with little investigation into combination therapies. Of note, UTUC patients frequently have impaired renal functions, making a chemotherapy-independent approach a desirable alternative. On the other hand, given the short duration of neoadjuvant therapy, a combination therapy strategy appears to be necessary, especially with the increasing interest in immune therapy maintenance after surgery. Tislelizumab has demonstrated efficacy in patients with advanced or metastatic urothelial carcinoma. Disitamab Vedotin, a HER2-targeting antibody-drug conjugate (ADC), has demonstrated robust clinical efficacy in metastatic urothelial carcinoma patients with HER2 2+ or 3+ expression. Disitamab Vedotin in combination with PD-1 immunotherapy has shown remarkable results in locally advanced or metastatic urothelial carcinoma, regardless of HER2 expression, indicative of a synergistic effect between ADC and PD-1 immunotherapy. In this study, we aim to conduct a prospective phase II trial to investigate the efficacy and safety of neoadjuvant tislelizumab plus Disitamab Vedotin followed by adjuvant tislelizumab in patients with high-risk UTUC. Methods: This multi-center phase II trial aims to enroll 45 patients with histologically confirmed UTUC at clinical stage cT2-4N0M0 or cT1-4N1-2M0. Neoadjuvant therapy includes 4 cycles of Tislelizumab (200mg for each 3-week cycle) in combination with Disitamab Vedotin (2.0mg/kg for each 3-week cycle). Radical nephroureterectomy (including bladder cuff resection and regional lymph node dissection if indicated) will be performed if there is no obvious contraindication within 3-6 weeks after the final neoadjuvant therapy administration. Postoperative adjuvant treatment with 8 cycles of tislelizumab will be provided. The primary endpoint is pathological complete response rate. Secondary endpoints include overall survival, local recurrence free survival, distant metastasis free survival, FACT–G. Clinical trial information: ChiCTR2300067836 .
Phase 3 KEYNOTE-676 cohort A: Bacillus Calmette-Guérin (BCG) with or without pembrolizumab for high-risk (HR) non–muscle-invasive bladder cancer (NMIBC) that persists/recurs after BCG induction.
Authors: Shore Neal D. , Nishiyama Hiroyuki , Shariat Shahrokh F. , Steinberg Gary , Kamat Ashish M. , Alanee Shaheen Riadh , Nam Kijoeng , Imai Kentaro , Kapadia Ekta , Hahn Noah M.
Published: January 2024

TPS722

Background: Intravesical instillation of BCG is a standard-of-care treatment for patients with HR NMIBC, but up to 50% of patients later experience disease recurrence or progression to muscle-invasive bladder cancer (MIBC) despite BCG treatment. In the phase 2 KEYNOTE-057 study (NCT02625961), pembrolizumab monotherapy was shown to have antitumor activity in patients with HR BCG–unresponsive NMIBC who had carcinoma in situ (CIS) with or without papillary tumors and in patients with only papillary tumors. In cohort A of the randomized, phase 3 KEYNOTE-676 trial (NCT03711032), pembrolizumab plus BCG versus BCG alone is being evaluated in patients with persistent/recurrent HR NMIBC after first BCG induction. Methods: Key eligibility criteria include adults with histologically confirmed HR NMIBC (T1, high-grade Ta, and/or CIS) that is persistent/recurrent following 1 adequate course of BCG induction therapy, have no concurrent extravesical disease or history of extravesical disease that recurred within 2 years, have an ECOG PS score of 0 to 2, and have undergone cystoscopy/TURBT ≤12 weeks before randomization. Approximately 430 patients will be randomly assigned 1:1 to receive pembrolizumab 200 mg intravenously every 3 weeks plus BCG or BCG alone. BCG (50 mg) will be administered by intravesical instillation as induction therapy once weekly for 6 weeks and then as maintenance therapy once weekly for 3 weeks at weeks 13 and 25, then every 24 weeks (Q24W) thereafter. Treatment will continue for approximately 2 years (pembrolizumab) or 3 years (BCG), or until confirmed persistent/recurrent HR NMIBC or disease progression to MIBC or metastatic bladder cancer, unacceptable toxicity, or withdrawal. Randomization to treatment will be stratified by PD-L1 combined positive score (≥10 or ˂10), histology (CIS or non-CIS), and NMIBC disease history (persistence/recurrence 0 to ≤6 months or recurrence ˃6 to ≤12 months or recurrence ˃12 to ≤24 months). Response will be assessed by local cystoscopy and blinded independent central review of urine cytology and biopsy (as applicable) every 12 weeks for years 1 to 2 and Q24W for years 3 to 5. Computed tomography urography will occur every 72 weeks through year 5, then every 104 weeks thereafter. The primary end point is complete response rate in patients with CIS. Secondary end points are duration of response in patients with CIS, event-free survival, recurrence-free survival, time to cystectomy, overall survival, disease-specific survival, safety and tolerability, and patient-reported outcomes. Enrollment incohort A of KEYNOTE-676 is ongoing in Asia, Australia, Europe, and North America. Clinical trial information: NCT03711032 .
Efficacy and safety of the combination of cisplatin plus nab-paclitaxel and nivolumab with radiotherapy after maximal tumor resection in non-metastatic muscle invasive bladder cancer (CNN-BC trial).
Authors: Ciccarese Chiara , Iacovelli Roberto , Alitto Anna Rita , Anghelone Annunziato , Sparagna Ileana , Tagliaferri Luca , Palermo Giuseppe , Racioppi Marco , Tortora Giampaolo
Published: January 2024

TPS723

Background: The therapeutic gold standard for muscle invasive bladder cancer (MIBC) is radical cystectomy (RC) preceded by neoadjuvant chemotherapy when appropriate. However, RC is a major surgery procedure with 13% rate of severe complication and a perioperative mortality rate of about 1.5 - 5 %. Trimodal therapy (TMT) is a “bladder sparing” option alternative to RC. TMT consists of complete transurethral bladder tumor resection (TURBT) followed by a combination of systemic chemotherapy and locoregional radiotherapy (RT), with the option of “salvage” cystectomy in case of local treatment failure. Immunotherapy with anti-PD1/PD-L1 monoclonal antibody significantly improves survival of metastatic BC patients, and it seems to potentiate the activity of RT without increased toxicity. Therefore, we investigate the role of a multimodal TMT strategy to increase the disease-free survival (DFS) and avoid or delay RC in non-metastatic MIBC pts. Methods: CNN-BC trial (NCT05203913) is a phase 2, open-label, mono-institutional study evaluating the activity and safety of TMT with cisplatin, nab-paclitaxel and nivolumab as systemic therapy in non-metastatic MIBC pts. Eligible pts should have undergone complete TURBT with diagnosis of T2-T3 N0M0 urothelial carcinoma, and no evidence of lymph nodes or metastatic disease at FDG-PET within 6 weeks from the start of treatments. TMT consists of nivolumab (480 mg IV every 4 weeks for a total of 13 doses), weekly nab-paclitaxel (60mg/m2) plus cisplatin (20mg/m2) administered concurrently with RT (60Gy in 25 fractions over 5 weeks on original bladder tumor, plus a concomitant boost of 50Gy in 25 fractions on whole bladder and pelvic nodes). The primary endpoint is the 1-year DFS rate, defined as the rate of survival free of recurrence in pelvic nodes or bladder, or appearance of distant metastases. Secondary endpoints include: the rate of pts who require salvage cystectomy, the rate of locoregional complete response (CR) and of locoregional DFS, median DFS, safety, and quality of life. Exploratory biomarkers analysis will be performed. The trial is actively recruiting. Clinical trial information: NCT05203913 .
Realized semicovariances: Empirical applications to volatility forecasting and portfolio optimization
Authors: Ricco Rafael , Ziegelmann Flavio A.
Published: January 2024

We propose a two-fold empirical study applying the concept of realized semicovariances as introduced by Bollerslev et al. (2020): in the first part of the paper we aim to estimate and forecast the realized volatility of an equally weighted portfolio formed by Brazilian B3 asset returns, whereas in the second part we search and find an optimum portfolio for these returns. In both parts we use high frequency data of ten assets from different segments and among the most negotiated in B3 financial market from July 2018 to January 2021. In addition, we investigate whether a Markov Switching strategy fits well to our volatility modeling approach considering that our observed data starts some time before the Covid-19 pandemic and spans well into the pandemic period. Machine Learning Regularization (LASSO) methods are employed to select covariates and potentially improve volatility estimation and forecasting. In the portfolio optimization analysis we see that under higher frequency rebalancing periods, minimum variance portfolios using the negative semicovariance matrices present better performances in terms of risk-adjusted returns compared to those that use the standard realized covariance matrices. In general we see that the realized semicovariances bring improvements to the solutions of our two problems.
Efeitos da incerteza da política econômica sobre a economia brasileira
Authors: Silva Pierre Hítalo Nascimento , Da Nóbrega Besarria Cássio , Pereira da Silva Maria Daniella de Oliveira
Published: January 2024

Este artigo tem como objetivo investigar os efeitos resultantes do impacto de um choque de incerteza da política econômica em um conjunto de variáveis macroeconômicas. O indicador de incerteza da política econômica foi previamente construído utilizando as atas das reuniões do Copom por meio da técnica de análise de sentimento textual. A base de dados deste artigo é composta por 63 séries temporais, abrangendo o período de janeiro de 2003 a dezembro de 2021. O modelo Factor-Augmented Vector Autoregressive (FAVAR) foi empregado com o objetivo de investigar os efeitos desse choque sobre uma ampla variedade de variáveis. Os resultados mostraram que o aumento da incerteza tem um impacto negativo em variáveis como o preço das ações, títulos da dívida pública e o Risco-País. Por outro lado, observou-se um efeito positivo na busca por ativos seguros e na realocação de recursos investidos no exterior, indicando a busca por países com maior estabilidade. Essa dinâmica resulta em uma reorganização dos portfólios, onde a liquidez e a segurança ganham maior importância.
Governança corporativa e eficiência técnica das empresas de água e esgoto no Brasil: Uma análise empírica
Authors: Amorim de Andrade Luiz Abel , Colombo Jéfferson Augusto , Esteves Luiz A.
Published: January 2024

Embora a dimensão de governança corporativa seja frequentemente apontada no debate público como um aspecto limitador da universalização dos serviços de saneamento no Brasil, estudos empíricos sobre o tema são escassos. Para suprir essa lacuna, este estudo desenvolve um Índice de Governança Corporativa (IGC) para uma amostra de 53 prestadoras de serviço de água e esgoto no Brasil. Utiliza-se esse indicador para avaliar empiricamente seus efeitos sobre o nível de eficiência técnica das empresas do setor, estimado por meio da análise envoltória de dados, entre 2015 e 2019. Os resultados da aplicação de modelos de regressão linear, com diferentes especificações, sugerem que a governança corporativa não influencia positivamente a eficiência técnica de tais empresas, ceteris paribus. A variável tamanho, por outro lado, parece ser um forte determinante da eficiência. Tais resultados possuem implicações diretas para gestores públicos e privados e contribuem para o debate atual sobre modernização e melhoria de eficiência das empresas de saneamento no Brasil.
Η επίδραση του ηπατοκυτταρικού αυξητικού παράγοντα στην προσαρμογή του λεπτού εντέρου μετά από εκτεταμένη εντερεκτομή
Authors: Μπάγιας Γεώργιος
Published: January 2024

Σκοπός: Η καθιερωμένη θεραπεία για ασθενείς με σύνδρομο βραχέος εντέρου (ΣΒΕ) είναι η παρεντερική διατροφή (Πδ). Διάφοροι αυξητικοί παράγοντες έχουν δοκιμαστεί προκειμένου να επιτευχθεί απογαλακτισμός από παρατεταμένη χορήγηση ΠΔ. Στην μελέτη αυτή αξιολογούμε την επίδραση του αυξητικού παράγοντα ηπατοκυττάρων (HGF) στη δομική εντερική προσαρμογή και τον κυτταρικό πολλαπλασιασμό σε ένα μοντέλο ΣΒΕ αρουραίου. Μέθοδοι: Τριάντα αρουραίοι Sprague-Dawley χωρίστηκαν σε τρεις ομάδες. Οι αρουραίοι της ομάδας Α (sham) υποβλήθηκαν σε διατομή του εντέρου, οι αρουραίοι της ομάδας Β υποβλήθηκαν σε εκτομή εντέρου κατά 75% και οι αρουραίοι της ομάδας Γ υποβλήθηκαν στην ίδια διαδικασία αλλά υποβλήθηκαν σε θεραπεία μετεγχειρητικά με HGF. Προσδιορίστηκαν οι ιστοπαθολογικές παράμετροι της εντερικής προσαρμογής, ενώ πραγματοποιήθηκαν και αναλύσεις μικροσυστοιχίας και rt-PCR από RNA που συλλεχθηκε από τον ειλεό. Αποτελέσματα: Η θεραπεία με HGF είχε ως αποτέλεσμα σημαντική αύξηση στο σωματικό βάρος, ενώ το ύψος των εντερικών λαχνών και το βάθος των εντερικών κρυπτών τόσο της νήστιδας όσο και του ειλεού αυξήθηκαν στους επίμυες της ομάδας Γ (36%, P<0,05 και 27%, P<0,05 αντίστοιχα). Ο πολλαπλασιασμός των εντεροκυττάρων αυξήθηκε επίσης σημαντικά στους επίμυες της ομάδας Γ (21% Ρ<0,05). Οι μικροσυστοιχίες και οι ποσοτικές αναλύσεις rt-PCR έδειξαν ότι τα γονίδια hgfac , rac 1, cdc42 και akt 1 ρυθμίστηκαν περισσότερο από δύο φορές προς τα πάνω μετά τη θεραπεία με HGF. Συμπέρασμα: Ο HGF αναδύεται ως αυξητικός παράγοντας που ενισχύει την εντερική προσαρμογή. Η μελλοντική χρήση του HGF μπορεί ενδεχομένως να μειώσει την απαίτηση για ΠΔ σε ασθενείς με ΣΒΕ.
The present of the past at a time of no future
Authors: Δήμου Βασίλειος
Published: January 2024

Η μακροχρόνια σχέση της επιστήμης της Αρχαιολογίας με την Τέχνη της εποχής της εκδηλώνεται ποικιλοτρόπως καθόλη την ιστορία της. Μια νέα έκφανση αυτής της σχέσης αποτελούν τα έργα ενός μικρού αριθμού αρχαιολόγων που, τις τελευταίες τρεις δεκαετίες, χρησιμοποιούν τα έργα τέχνης και την καλλιτεχνική δημιουργία ως εργαλεία για την έρευνα και την συμπερίληψη του κοινού. Οι πειραματισμοί τους τεκμηριώνονται σε έναν μικρό αλλά σημαντικό αριθμό περιγραφικών και αναστοχαστικών δημοσιεύσεων, οι οποίες μέχρι τώρα εμφανίζονταν διάσπαρτες στη βιβλιογραφία ως μεμονωμένα, μεταξύ τους ασύνδετα, παράπλευρα έργα. Η προσεκτική συστηματοποίηση και ιστορικοποίησή τους, ωστόσο, δείχνει πως συνολικά αποτελούν μια μη συντονισμένη κριτική της νεωτερικής κληρονομιάς της σύγχρονης αρχαιολογικής πρακτικής και διατυπώνουν, έστω και αποσπασματικά, μια πρόταση για μια νέα εναλλακτική. Στο πρώτο μέρος της διατριβής μου εντοπίζω και συναρμολογώ τα μέρη της προαναφερθείσας κριτικής και πρότασης εξετάζοντας (τόσο μεμονωμένα όσο και συγκριτικά) τις γενεαλογίες και τα κίνητρα κάθε έργου που περιγράφεται στις δημοσιεύσεις. Στο δεύτερο μέρος, βασιζόμενος στην αξιολόγηση των θετικών χαρακτηριστικών και των ελλείψεων αυτών των έργων, διερευνώ τις δυνατότητες μιας τοποειδικής εθνογραφικής καλλιτεχνικής εγκατάστασης ως εργαλείου αποδόμησης των ηγεμονικών αφηγήσεων σχετικά με τα υλικά κατάλοιπα του παρελθόντος και ενθάρρυνσης της ανάπτυξης προσωπικών συνδέσεων με αυτά, χρησιμοποιώντας ως μελέτη περίπτωσης την Ακρόπολη της Αθήνας στα χρόνια της λεγόμενης "κρίσης".
Ανατομική και θεραπευτική προσέγγιση καταγμάτων καταπόνησης του ιερού οστού
Authors: Τσατσαράγκου Αικατερίνη
Published: January 2024

Τα κατάγματα κοπώσεως του ιερού οστού αποτελούν μια κλινική οντότητα που μπορεί να διαλάθει της διάγνωσης. Λίγα περιστατικά έχουν αναφερθεί στη βιβλιογραφία. Η συγκεκριμένη μελέτη παρουσιάζει μία μεγάλη σειρά τέτοιων περιστατικών αναφέροντας επιδημιολογικά στοιχεία, στοιχεία σχετικά με τη διάγνωση και τη θεραπεία. Η παρούσα είναι μια αναδρομική μελέτη παρατήρησης του από προοπτικά συντηρούμενη βάση δεδομένων. Όλοι οι ενήλικες (>18 ετών) ασθενείς που έλαβαν θεραπεία για ένα κάταγμα καταπόνησης ιερού οστού στο Τμήμα Ορθοπαιδικής και Τραυματολογίας του «Βενιζέλειου» Γενικό Νοσοκομείου Ηρακλείου Κρήτης, από τον Ιανουάριο του 2000 έως τον Ιανουάριο του 2022 καταγράφηκαν στην μελέτη. Κατά τη διάρκεια αυτής της 23- ετούς περιόδου, συνολικά 17 περιπτώσεις (13 γυναίκες, 76,5% και 4άνδρες 23.5%) συμπεριλήφθηκαν στη μελέτη. Η μέση ηλικία του πληθυσμού που μελετήθηκε βρέθηκε να είναι 33,6 έτη. Η διάγνωση τέθηκε στις περισσότερες περιπτώσεις με μαγνητική τομογραφία (MRI), ενώ σε 2 περιπτώσεις (11.8%) χρησιμοποιήθηκε η αξονική τομογραφία για την τελική διάγνωση και σε 1 το σπινθηρογράφημα (5.9%). Σχετικά με τα ιατρικά ιστορικό 3 ασθενείς (17.6% %) είχαν υποφέρει από κατάγματα κόπωσης στο παρελθόν, ένα από κνήμη και δύο από κάταγμα μεταταρσίου. Σχετικά με την εντόπιση των καταγμάτων, τα περισσότερα (14 περιπτώσεις, 66.6%) εντοπίστηκαν στην πτέρυγα του ιερού οστού, ενώ τα υπόλοιπα 7 (33.3%) στο σώμα. Σύμφωνα με την Ταξινόμηση Kaeding Miller, 9 κατάγματα (42.9%) χαρακτηρίστηκαν με βαθμό II, 8 (38.1%) με βαθμό III και 4 (19%) με βαθμό IV. Συμπερασματικά, τα κατάγματα καταπόνησης ιερού οστού αντιπροσωπεύουν συχνά μια κλινική οντότητα λανθασμένης διάγνωσης. Ως εκ τούτου, η διαφορική διάγνωση για ένα χρόνιο άλγος στην οσφύ ή στο οπίσθιο ισχίο σε νεαρούς ασθενείς που εμπλέκονται με τον αθλητισμό, ειδικά σε γυναίκες δρομείς, θα πρέπει να περιλαμβάνει το κάταγμα κόπωσης ιερού οστού. Ιστορικό άλλων τραυματισμών κόπωσης φαίνεται να είναι προδιαθεσικός παράγοντας.
STUDYING THE POTENTIAL OF THE REPUBLIC OF BASHKORTOSTAN FOR THE DEVELOPMENT OF INTERREGIONAL INTERACTION
Authors: Biglova Alfiya A.
Published: January 2024

In order to increase the competitiveness of the region and the competent distribution of production forces, leveling the socio-economic and financial imbalance in modern conditions accompanied by external pressure and instability of economic development, there is a growing need to focus on increasing the efficiency of using potential of the region.

Purpose. study of the potential of the Republic of Bashkortostan to expand interregional cooperation

Methodology in the process of writing the article, theoretical methods of analysis and synthesis, generalization and classification were used. The information basis of the study was normative and methodological sources, legislative acts of the Russian Federation, data from official government websites of the Russian Federation, educational and specialized literature, periodicals in the field of regional development, interregional interaction, as well as statistical data.

Results: informative data was obtained reflecting aspects of the development of interregional interaction

Practical implications it is advisable to apply the obtained results in order to develop and improve the quality of management decisions in the formation of interregional interaction for the sustainable economic development of the country.
IMPROVEMENT OF THE SYSTEM OF MATERIAL AND TECHNICAL SUPPORT OF METAL ROLLING AT MACHINE-BUILDING ENTERPRISES
Authors: Isavnin Alexey G. , Nizamova Liliya N. , Frolova Olga N.
Published: January 2024

Material and technical support is an important stage in the production activity of the enterprise, since the competent organization of this process directly affects the cost of the final product. The procedure for registering receipts, taking into account the use of information systems, as well as electronic document management, involves a certain sequence of steps from the moment of arrival at the warehouse to transfer to production. An efficiently built process allows you to eliminate storage costs, failures in logistics flows, duplication of information. The peculiarity of the system of material and technical support of metal rolling enterprises of the machine-building industry implies a delay in obtaining in the primary documents necessary for the prompt registration of receipt in the system and transfer of goods to production. This article discusses a new format of interaction with metal suppliers, proposes a new procedure for registering the receipt of rolled metal on the basis of quality certificates from the processor. The essence of this innovative approach is to register receipt with reference to the number of the processor's certificate, since it contains all the necessary information for acceptance by quantity and quality. To automate the signing of electronic primary documents based on the reconciliation of data in an electronic document, it is necessary to define a new tag to indicate the certificate number. Thus, a link will be established between the incoming delivery in the buyer's system and the supplier's electronic document for automatic electronic signing.

Purpose. Optimization of the process of material and technical support by metal rolling for enterprises of the machine-building industry.

Methodology: the article used survey, analysis, comparison, modeling.

Results: new procedure for registering the receipt of rolled metal products on the basis of quality certificates from the processor, which allows avoiding storage costs, errors in duplicating information.

Practical implications it is advisable to apply the obtained results for enterprises of the machine-building industry engaged in the purchase of rolled metal.
E-course "Care of surgical child and adolescents"
Authors: Tsap Natalia , Kurova Ekaterina , Gordienko Ivan , Komarova Svetlana , Ognev Sergey , Rubtsov Vladislav , Shnaider Inna , Borisov Semen , Suenkova Daria , Zhaksylykov Askar
Published: January 2024

The purpose of the discipline is the initial formation of general cultural, general professional and professional competencies when working with children from 0 to 18 years old in various surgical departments. As a result of studying the discipline ""Caring of surgical child and adolescents "" the student must know: general principles of patient care in pediatric surgical departments, rules of conduct for medical personnel, Sanitary and anti-epidemic regime of emergency room, surgical and resuscitation departments, operating block. Concepts of asepsis and antisepsis. Rules and methods of processing the hands of medical staff. Features of observation and care of sick children and adolescents with diseases of various body systems.
Phthisiology
Authors: Minogina Tatyana , Sabadash Elena
Published: January 2024

Electronic training course "Phthisiology" is compiled in accordance with the requirements of the Federal State Educational Standard of Higher Education speciality 31.05.01-Medicine, 31.05.02-Pediatrics, 32.05.01-Medico-Preventive Medicine, 31.05.03-Dentistry. Purpose of the discipline: Acquisition by students of the necessary amount of theoretical and practical knowledge, skills and abilities in the discipline "Phthisiology". Electronic training course contains information about the epidemiological situation of tuberculosis, social significance of this disease, ways to prevent the spread of infection, the role of various risk factors of tuberculosis development, knowledge about etiology and pathogenesis of tuberculosis infection, clinical symptoms and syndromes, diagnostic criteria of the main nosological forms of tuberculosis infection, knowledge of the peculiarities of pathogenesis, detection, diagnosis and clinical manifestations of tuberculosis of various localisations in patients of different ages. Purpose of the course - to be used for educational and methodological purposes
Electronic training manual "Acute drug poisoning"
Authors: Sentcоv Valentin , Reutov Andrei , Kuzmin Vyacheslav
Published: January 2024

The widespread use in modern medicine of hypnotics, sedatives, tricyclic antidepressants, antihypertensive drugs and antipyretics, even in therapeutic dosages, sometimes leads to adverse consequences for the patient. Accidental or intentional excess of therapeutic dosages leads to severe poisoning. This fact indicates the high relevance of doctors’ knowledge of any clinical specialty and the treatment of poisoning by these groups of drugs. This electronic educational resourse consists of six theoretical educational modules: poisoning with barbituric acid derivatives, acute poisoning with tricyclic antidepressants, acute poisoning with beta-blockers, poisoning with clonidine, acute poisoning with anti-tuberculosis drugs, acute poisoning with paracetamol. The theoretical block of modules is presented by presentations, the text of lectures with illustrations. Control classes in the form of test control accompany each theoretical module. After studying all modules, the student passes the final test control. Mastering the electronic educational resourse will ensure a high level of readiness to provide specialized toxicological care by doctors of various specialties.
Electronic training manual "Acute poisoning with alcohols and alcohol-containing liquids"
Authors: Sentcоv Valentin , Reutov Andrei , Kuzmin Vyacheslav
Published: January 2024

In the structure of acute poisonings, ethanol poisoning currently accounts, according to various sources, from 10 to 20%. The mortality rate in poison control centers for ethanol poisoning is 1-2%, but the mortality rate is much higher due to those who died before medical care was provided. The widespread use of methanol and ethylene glycol in various industries and the high mortality rate with late recognition of poisoning with these alcohols determine the high relevance of a detailed study of the clinic, diagnosis and treatment of these poisonings by doctors of various specialties. In particular, toxicologists from health care institutions, anesthesiologists and resuscitators from health care institutions, doctors from specialized emergency medical services teams, and disaster medicine doctors. Competent and timely diagnosis, hospitalization in a specialized hospital and previously started treatment greatly increases the patient’s chances of life and its further quality. This electronic educational resourse consists of six theoretical educational modules: general issues of clinical toxicology, acute poisoning with veratrine, acute poisoning with ethanol, poisoning with methanol, poisoning with ethylene glycol, acute poisoning with other alcohols. The theoretical block of modules is presented by presentations, the text of lectures with illustrations. Control classes in the form of test control accompany each theoretical module. After studying all modules, the student passes the final test control. Mastering the electronic educational resourse will ensure a high level of readiness to provide specialized toxicological care by doctors of various specialties.
Electronic educational resource "Hospital Surgery for 5th year students of the Faculty of Pediatrics"
Authors: Prudkov Mikhail , Ermolaev Vasily , Shurygina Elena , Mikaelyan Eduard
Published: January 2024

Electronic educational resourc was created for independent work of 5th year students of the pediatric faculty in the study of the discipline "Hospital Surgery". The possibility of control by the teacher is provided. This EER includes an introductory module, a topic module, and a quality assessment module. The structure of each topic in the EER (there are 19 topics in total) consists of the following sections: educational and methodological tasks on the topic, abstract of the topic, control tests on the topic, clinical situational tasks on the topic and a list of references. The section "Summary of the topic" at the moment can be presented in the form of a text file, or a presentation, or a video lecture, or a monograph by the staff of the department, etc. This section is gradually updated with new materials. The section "Control tests on the topic" is designed to control the teacher for the independent work of students and contains 15 tests, the solution of which is given 10 minutes and two attempts, a passing result for crediting 71% of correct answers. The section "Clinical situational tasks" serves for self-control of the student in mastering the topic - if he understood the content of the task, made a preliminary diagnosis and knows the tactics of managing the patient, the topic is mastered. There are ten clinical situational tasks for each topic, students receive different versions of tasks. In addition, the EER has a "Final test control" section, which contains test tasks from all topics of practical classes. The program randomly generates a final test of 30 tasks, 20 minutes are allotted for solving, the student has the right to two attempts. More than 71% of correct answers are counted.
Electronic educational resource "Basic aspects of narcology"
Authors: Bogdanov Sergey I.
Published: January 2024

The electronic educational resource (hereinafter referred to as EER) “Basic aspects of narcology” is designed for 36 training hours. This distance learning course aims to develop communicative competence, prepare for solving standard problems of professional activity using information resources, medical and biological terminology, and is also aimed at optimizing the educational process at the university, creating conditions for achieving the required level of modern education and comprehensive development of the personality of students . The EER was developed in accordance with the Federal State Educational Standard of Higher Education. Intended for medical school students as a material that allows future doctors to become more in-depth acquainted with the basic aspects of narcology, as well as for psychiatrists, psychiatrists-narcologists, and doctors of other specialties who, due to the specifics of their work, systematically interact with patients with drug addiction pathology. The EER was developed by Doctor of Medical Sciences, Associate Professor, highly qualified psychiatrist-narcologist with 37 years of experience in the specialty of psychiatry-narcology. The structure of the EER is classic and includes an abstract, glossary, instructions for working with the course, brief information about the authors, a methodological block, 4 lectures in presentation format and video lectures on the following topics: “Ethanol from the birth of modern civilization to the creation of new stars”, “Alcoholism”, “General issues of addiction” and “Classification of substances and drugs that cause addiction.” To control the studied material, clinical tasks and final testing on the topic being studied are used. To receive feedback from cadets and students, there is a feedback form. A student who has mastered the program is able to possess professional competencies, including the ability to: professionally navigate issues of terminology and definitions related to the subject of the educational material; master the amount of knowledge on the mechanisms of the effects of psychoactive substances on the human body; correctly navigate the issues of modern classification of surfactants; correctly diagnose pathological conditions associated with chronic ethanol intoxication; apply distance educational technologies (DET) in professional activities; use automated information systems and knowledge bases in professional activities.
Electronic training manual "Psychiatry, medical psychology"
Authors: Sidenkova Alena , Kremleva Olga , Bogdanov Sergey , Esina Olga , Melnik Alena
Published: January 2024

The electronic training course ""Psychiatry, Medical Psychology"" was compiled in accordance with the requirements of the Federal State Educational Standard of Higher Education, specialty 31.05.01 General Medicine, approved by order of the Ministry of Education and Science of the Russian Federation dated February 9, 2016 No. 95, and taking into account the requirements of the professional standard 02.009 “Physician (precinct general practitioner)”, approved by order of the Ministry of Labor and Social Protection of the Russian Federation dated March 21, 2017 No. 293n, as well as in accordance with the requirements of the Federal State Educational Standard of Higher Education in the specialty 31.05.02 Pediatrics (specialty level), approved by order of the Ministry of Education and Science of the Russian Federation dated 08/17/2015 No. 853, and taking into account the requirements of professional standard 02.008 “Physician - district pediatrician”, approved by order of the Ministry of Labor and Social Protection of the Russian Federation dated 03/27/2017 No. 306n. This course includes issues of private psychiatry and narcology. The purpose of the course is to gain knowledge about the basic patterns of formation and manifestations of mental disorders, their causes, and classification principles. Course objectives: study of classifications of mental disorders; familiarization with the clinical manifestations of mental disorders, their etiological and pathogenetic mechanisms; teaching students the skills to identify symptoms of mental disorders and the skills of describing them in medical documentation. The labor intensity of the course is 45 hours. The course consists of 5 didactic units.
Electronic training course "Theoretical foundations of physical culture"
Authors: Khairulin Alexander , Blinkov Vladimir , Lagunova Lyubov , Sapozhnikova Olga , Byzov Evgeny , Freifeld Irina , Malozemov Oleg , Ryamova Ksenia , Krokhalev Konstantin , Revenko Aliya , Braslavets Olesya , Filippov Andrey
Published: January 2024

The electronic training course “Theoretical Foundations of Physical Culture” contains fifteen topics that allow students to understand: the basic concepts of physical culture (PC) and sports; its role in general cultural and professional training; socio-biological foundations of PC; the role of motor activity for modern man; the basics of a healthy lifestyle; means of PC in the regulation of life activity; basics of general physical and sports training; the basics of the theory and methodology of physical education; the basics of methods for organizing and conducting independent physical education and recreational activities; the basics of self-control and functional diagnostics during physical education classes; professional and applied physical training of university students; basics of health PC; doping problems in sports activities; the basics of massage and its connection with PC; information on sports injuries; basics of adaptive PC The content of each topic includes a lecture part, designed in the form of an illustrated test with hyperlinks, a presentation on the lecture, a practical assignment on the material of the topic, as well as a test assignment (of ten questions) on the topic. The final control of students' completion of the course is carried out by sequential study of topics (all or several, depending on the curriculum of the specialty) and the accumulation of at least 70% of correct answers on control tests. In addition to the lecture material and practical assignments, the electronic training course contains information necessary for students to master the educational material in a high-quality manner, in the form of additional reference (glossary) and educational literature previously published by the authors of this course. The structure and content of the electronic course complies with the requirements of the Federal State Educational Standard for the academic discipline “Physical Culture and Sports”, as well as the requirements of the USMU for the structure and content for this educational tool.
Chronic Pelvic Pain Syndrome among women - challenge in diagnostics and management. Current literature review
Authors: Zielińska Zuzanna , Nowak Karolina , Olejarz Zuzanna , Drygała Zuzanna , Wyrwał Julia , Słowik Magdalena , Nowak Karolina , Nieć Maria , Gierlach Katarzyna , Krasuska Martyna
Published: January 2024

Introduction and purpose:

Chronic Pelvic Pain Syndrome (CPPS) is characterized as intermittent or constant pain located in the lower abdomen or pelvis, persisting continuously for at least 6 months [1]. Reports on the prevalence of chronic pelvic pain indicate the occurrence of this condition at a level of 5.7–26.6% in women of reproductive age. However, only a third of women suffering from chronic pelvic pain, seek medical care [2].

Clinical picture of CPPS consists of various patterns and symptoms, often as the intersection of the multiple systems, which additionally complicates and delays the diagnostic process.

The aim of this review is to summarize existing literature about the diagnostics and management of Chronic Pelvic Pain Syndrome among women and create an awareness about the challenges which this condition poses for healthcare professionals. 

A brief description of the state of knowledge:

Chronic Pelvic Pain Syndrome is a multifaceted condition and the pathophysiology of it has not yet been comprehensively studied. Clinical picture often involves dysfunctions in pelvic floor, urinary tract, or gastrointestinal system. Treatment involves a multidisciplinary approach including non-pharmacological and pharmacological interventions.

 Summary (conclusions):

Chronic Pelvic Pain is a complex condition involving symptoms affecting the psychological, gastrointestinal, musculoskeletal systems. The most successful treatment approach emphasizes the role of collaboration among a diverse team of specialists such as gynecologists, gastroenterologists, psychiatrists, psychologists, and physiotherapists. More research focused on multimodal strategies in management of the CPP is needed to match patients most effectively with the most suitable combination of treatment and reduce the systemic consequences of chronic pain.
Tanatokosmetyka wyrazem pietyzmu wobec zwłok ludzkich
Authors: Gwoździewicz Tomasz
Published: January 2024

Artykuł przedstawia zagadnienie tanatokosmetyki jako wyrazu pietyzmu do zwłok ludzkich. Ciało człowieka po śmierci domaga się właściwego traktowania, szczególnie w momencie przygotowania do pożegnania. Jedną z czynności, którą współcześnie się wykonuje jest makijaż pośmiertny. Właściwie wykonany zabieg stanowi wyraz szacunku i troski o zwłoki ludzkie. Z drugiej strony poprzez niewłaściwe jego wykonanie można narazić ciało człowieka zmarłego na ośmieszenie, a nawet profanację. Zastosowana w artykule metoda analizy pozwala na ukazanie specyfiki zjawiska, zaś wnioski, z badań, które tworzą syntezę umożliwiają podkreślenie moralnych aspektów zagadnienia.
Twórcza odwaga na miarę św. Józefa w ujęciu papieża Franciszka
Authors: Jaśkiewicz Sylwester
Published: January 2024

Mając na uwadze żywotne zainteresowanie problematyką odwagi w obrębie różnych dyscyplin naukowych, artykuł stara się uwydatnić jej chrześcijańskie korzenie w oparciu o nauczanie papieża Franciszka o św. Józefie. Ojciec Święty koncentrując się na fakcie ojcostwa Józefa oraz na misji powierzonej mu przez Opatrzność Bożą, zwraca uwagę na twórczą odwagę jako cechę typowo Józefową. Pierwszoplanowym źródłem rozważań o twórczej odwadze św. Józefa są dla biskupa Rzymu ewangeliczne opowiadania o jego snach. Poprzez zestawienie postaci Józefa z postacią Heroda papież Franciszek uwydatnia nie tylko dwa odwieczne oblicza ludzkości, ale pośród mroków i ciemności współczesnych czasów przypomina o św. Józefie, jako o świetlanym świadku odważnego zaufania Bogu i twórczego mierzenia się z trudnościami.
Baptysterium jubileuszu 900-lecia chrztu Pomorza w kościele pw. św. Jana Pawła II w Szczecinie
Authors: Krzystek Andrzej
Published: January 2024

Projekt i realizacja chrzcielnicy wiążą się z jubileuszem 900-lecia chrztu Pomorza Zachodniego, który upamiętnia misję chrystianizacyjną św. Ottona biskupa bamberskiego z lat 1124-1125 i 1128. Przedmiotem tego studium jest baptysterium, jego miejsce w przestrzeni liturgicznej, forma, ikonografia inspirowana teologią i historią, a także hermeneutyka teologiczna. Ikonografia historyczna upamiętnia ojców chrztu: św. Ottona i władców Bolesława Krzywoustego i Warcisława I. Połączenie treści teologicznych i historycznych sprawia, że chrzcielnica z jej przesłaniem jest swoistą katechezą, a także lekcją historii i kultury. Jako projekt badawczy: Baptysterium jubileuszu 900-lecia chrztu Pomorza, uzyskał akceptację Ministerstwa Edukacji i Nauki i został włączony do projektu naukowo-edukacyjnego: Chrzest Pomorza w dziejach Polski i Europy. Jubileusz 900-lecia.
La teoria della Percezione di Hans Urs von Balthasar nella «Verità del mondo»
Authors: Sierotowicz​ Tadeusz
Published: January 2024

Il testo propone una sintesi di teoria della percezione sviluppata da Hans Urs von Balthasar nell’opera Verità del mondo. Per poter risolvere una difficoltà evidenziata nell’approccio di Balthasar, la sua teoria viene successivamente confrontata con un approccio proposto da Dan Nesher.
Use of Machine Learning Models to Warmstart Column Generation for Unit Commitment
Authors: Sugishita Nagisa , Grothey Andreas , McKinnon Ken
Published: January 2024

The unit commitment problem is an important optimization problem in the energy industry used to compute the most economical operating schedules of power plants. Typically, this problem has to be solved repeatedly with different data but with the same problem structure. Machine learning techniques have been applied in this context to find primal feasible solutions. Dantzig-Wolfe decomposition with a column generation procedure is another approach that has been shown to be successful in solving the unit commitment problem to tight tolerance. We propose the use of machine learning models not to find primal feasible solutions directly but to generate initial dual values for the column generation procedure. Our numerical experiments compare machine learning–based methods for warmstarting the column generation procedure with three baselines: column prepopulation, the linear programming relaxation, and coldstart. The experiments reveal that the machine learning approaches are able to find both tight lower bounds and accurate primal feasible solutions in a shorter time compared with the baselines. Furthermore, these approaches scale well to handle large instances.

History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete.
media relations of Universitas Ahmad Dahlan Yogyakarta in maintaining image during the COVID-19 Pandemic
Authors: Pratiwi Nadia , Anisa Sari Eka
Published: January 2024

The COVID-19 pandemic in 2021 has affected the education in Indonesia, including the institution of Universitas Ahmad Dahlan (UAD) Yogyakarta.  The existence of educational institutions requires existence to gain the trust of the community. Public relations become an element that plays a role. During the COVID-19 pandemic, the use of media helps the public in obtaining and conveying information, including media coverage. Therefore, it is important for university public relations to have a good relationship with the media, considering that the media is a source of information providers. This study aims to determine the implementation of media relations carried out by UAD Public Relations in maintaining its image during the COVID-19 pandemic in 2021. The goal is to know and understand the implementation of media relations applied, starting from the research stage, preparation, communicating a program, and evaluations. This research method uses a qualitative with a case study approach and was analyzed using John E. Marston's R-A-C-E Formula. Based on data, at the research stage the implementation is not maximized, so that offline activities have no substitute activities. At the action stage, media relations activities include preparation of public relations writing skills, release materials, and advertising publication materials. Stages of communication conducting media relations activities, namely making press releases and advertising publications. In addition, to build a good relationship with the media, UAD Public Relations maintains personal contact with media partners, provides souvenirs, and Feast Day gifts.  Finally, at the evaluation stage, UAD Public Relations monitors publications and program evaluation.