bluuebunny/crossref_metadata_2025 huggingface dataset:
Prolonged Proton Pump Inhibitor Use and Thrombohemorrhagic Risk in Essential Thrombocythemia and Polycythemia Vera Patients Treated with Long-Term Aspirin: A Pilot Study
Authors: Krečak Ivan , Pivac Ljerka , Holik Hrvoje , Perić Martina Morić , Zekanović Ivan , Čubrić Eva , Skelin Marko , Lucijanić Marko
Published: January 2024

Introduction: Proton pump inhibitors (PPIs) are known to decrease the risk of gastrointestinal (GI) bleeding. However, concerns have been raised regarding the potential pharmacodynamic interactions of PPIs and antiplatelet drugs with respect to cardiovascular risk. Patients with BCR::ABL1-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), and polycythemia vera (PV) often suffer from peptic ulcer disease (PUD) and frequently receive low-dose aspirin due to an intrinsically high thrombotic risk. Method: This retrospective multicenter study from a community setting investigated whether continuous PPI use may affect thrombohemorrhagic risk in ET and PV patients treated with long-term aspirin. Results: Ninety-four aspirin-treated MPN patients (ET = 36, PV = 58) were included; median age was 69.5 years (range 21–92) and 40 (42.6%) were males. Nineteen (20.2%) patients continuously received PPIs and pantoprazole (n = 15, 78.9%) was the most frequently received PPI. PV phenotype (p = 0.085), male sex (p = 0.011), and prior thrombosis (p = 0.005) were associated with PPI use, whereas no correlations were found with respect to age, disease risk, splenomegaly, mutational status, constitutional symptoms, cardiovascular risk factors, cytoreductive treatment, or any of the blood cell counts (p > 0.050 for all analyses). The median follow-up time was 55.5 months; 19 (20.2%) thrombotic and 13 (13.8%) bleeding events occurred during this time. The use of PPIs was not associated with an increased risk of thrombosis (p = 0.158) or overall bleeding (p = 0.229) and none of the patients treated with PPIs experienced GI bleeding. Conclusions: Considering that Helicobacter pylori infection and PUD are quite frequent in ET and PV patients, these preliminary results may provide some reassurance to physicians regarding the absence of thrombohemorrhagic risk associated with prolonged PPI use in MPN patients treated with long-term aspirin. Our observations may be even more important in the light of recent evidence suggesting suboptimal platelet inhibition in ET with once-daily when compared to twice- or triple-daily aspirin which may also cause more abdominal discomfort. Limitations of this study are its retrospective design, limited number of patients included, and the lack of pharmacodynamic and pharmacokinetic assessments.
B-Zell-mediierte Autoimmunerkrankungen: Risiko für B-Zell-Lymphome?
Authors: Sticherling Michael
Published: January 2024

Primary cutaneous B-cell lymphomas (pcBCLs) are non-Hodgkin lymphomas present in the skin without evidence of extracutaneous involvement at diagnosis and include primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, intravascular large B-cell lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg-type [1]. While the etiology and pathogenesis of pcBCL is not fully understood, prior research suggests a possible association between autoimmune disease and primary cutaneous marginal zone lymphoma [2]. While it is known that patients with certain autoimmune disorders (systemic lupus erythematosus, autoimmune thyroiditis, Sjogren‘s, and sarcoidosis, among others) have an increased risk of developing non-Hodgkin lymphomas and other cancers due to chronic B-cell stimulation and immune dysregulation, little is known about the relationship between specific autoimmune diseases and pcBCL [3, 4].
Posterior Circulation Mechanical Thrombectomy through Primitive Trigeminal Artery: A Case Report
Authors: Gao Xiaoshan , Wang Tianhong , Chen Jun , Chen Jiangjun , Wang Ying , Yang Kui , Gu Youquan , Yao Lihe
Published: January 2024

Introduction: Primitive trigeminal artery (PTA) is a rare intracranial vascular malformation, and mechanical thrombectomy and revascularization via PTA are rarely reported. Case Presentation: We reported a case of mechanical thrombectomy through PTA in a patient who presented with sudden slurred speech and had a National Institutes of Health Stroke Scale score of 12. Digital subtraction angiography of the cerebral vasculature showed PTA formation in the right internal carotid artery cavernous segment, with acute occlusion of the distal basilar artery at the PTA junction, and bilateral vertebral arteries and proximal basilar artery were underdeveloped. Therefore, we chose mechanical thrombectomy via PTA, but unfortunately, the vessel failed to recanalize. Follow-up at 1-month post-procedure indicated that the patient had passed away. We present the endovascular process and analyze and summarize the reasons for the failure to provide a reference for subsequent mechanical thrombectomy via PTA. Conclusions: PTA increases the risk of ischemic stroke and adds to the complexity of mechanical thrombectomy post-stroke. However, in certain situations, PTA can be used as a thrombectomy channel to increase the first-line possibility of timely endovascular treatment to save ischemic brain tissue.
Mapping, Associated Factors, and Pathophysiology of Nodding Syndrome in Africa: A Systematic Review
Authors: Metanmo Salvatore , Dossa Djamirou , Ahmat Djibrine Nassir , Winkler Andrea Sylvia , Boumediene Farid
Published: January 2024

Introduction: Nodding syndrome (NS) remains a poorly understood disorder. For a long time, it has been thought to be restricted to East Africa; however, cases in Central Africa have been increasing over time. The objective of this systematic review (SR) was to provide a summary of the state of knowledge on NS to date. Methods: All original articles published on NS up to November 2021 were searched in four major databases and in the gray literature. Commentaries, editorials, book chapters, books, conference paper, qualitative studies that mentioned NS cases were also included. Data retrieved included study location (with GPS coordinates searched), year of study and publication, population characteristics, definition and diagnosis of NS, associated factors, and treatment if applicable. A meta-analysis of associated factors was performed where possible, and results were presented as odds ratios (ORs) and visualized as forest plots. Geographic information systems were used for cartographic representations. The quality of the articles included was assessed. Results: Of the 876 articles initially identified, 67 (corresponding to 59 studies) were included in the SR. NS is only present in Central and East Africa. Interestingly, there were reports of NS in Central Africa prior to 2010, earlier than previously thought. The way NS diagnosis was established varies according to studies, and the 2012 WHO classification was used in only 60% of the studies. Approximately 11% of the articles did not meet the quality requirements set for this review. In our meta-analysis, the main factor associated with NS was onchocerciasis (OR = 8.8 [4.8, 15.9]). However, the pathophysiology of the disease remains poorly understood. The lack of common anti-epileptic drugs is a significant barrier to the management of head nodding and associated epileptic seizures. Discussion/Conclusion: The lack of an operational definition of NS is an obstacle to its diagnosis and, thus, to its appropriate treatment. Indeed, diagnostic difficulties might have led to false positives and false negatives which could have altered the picture of NS presented in this article. Treatment should take into account nutritional and psychological factors, as well as associated infections. Some risk factors deserve further investigation; therefore, we suggest a multicentric study with an etiological focus using a more operational definition of NS.
Hyperthyroidism-Induced Upregulation of Neurodegeneration-Related Gene Expression in Metaplasticity-Induced Hippocampus
Authors: Babur Ercan , Altunkaya Melek , Tufan Esra , Süer Cem , Dursun Nurcan
Published: January 2024

Introduction: Thyroid hormones, which produce critical changes in our bodies even when their physiological levels alter slightly, are crucial hormones that influence gene transcription. Neuronal plasticity, on the other hand, requires both the activation of local proteins as well as protein translation and transcription in response to external signals. So far, no study has examined metaplastic long-term potentiation (LTP) and related gene expression levels in a hyperthyroid experimental model. Methods: The Wistar male rats were administered 0.2 mg/kg/day of l-thyroxine for 21 days to induce hyperthyroidism. Perforant path was primed with 1-Hz low-frequency stimuli (LFS) for 900 s to investigate metaplasticity responses. The LFS was followed by high-frequency stimuli (HFS, 100 Hz) after 5 min. Excitatory postsynaptic potential (EPSP) slope and population spike (PS) amplitude were recorded from the granule cell layer of the dentate gyrus. The mRNA levels of genes related to neurodegeneration (Gsk-3β, Cdk5, Akt1, Mapt, p35, Capn1, Bace1, and Psen2) were measured using the RT-PCR method for the stimulated hippocampus. Results: Similar to euthyroid rats, hyperthyroid animals had a lower EPSP slope and PS after LFS. Depression of EPSP prevented subsequently induced EPSP-LTP, although HFS was able to elicit PS-LTP despite depression of PS amplitude in both groups. Despite similarities in metaplastic LTP responses, these electrophysiological findings were accompanied by increased Akt, Bace1, Cdk5, and p35-mRNA expressions and decreased Gsk-3β mRNA expression in hyperthyroid rats’ hippocampus. Conclusion: These data support the view that in thyroid hormone excess, the mechanism that keeps synaptic efficacy within a dynamic range occurs concurrently with increased mRNA expression of neurodegeneration-related genes. Our study encourages further examination of the increased risk of neurodegenerative disease in hyperthyroidism.
Risk Factors for a Narrow Safety Margin after Endoscopic Submucosal Dissection for Early Gastric Cancer
Authors: Yeo Min Kyung , Kang Sun Hyung , Lee Hyun Seok , Eun Hyuk Soo , Moon Hee Seok , Lee Eaum Seok , Kim Seok Hyun , Sung Jae Kyu , Lee Byung Seok , Jeong Hyun Yong
Published: January 2024

Introduction: A narrow safety margin (NSM) after endoscopic submucosal dissection (ESD) is a well-recognized risk factor for local recurrence in early gastric cancer (EGC). However, only a few studies have investigated the risk factors for the development of NSM. Methods: The medical records and pathologic specimens of patients with EGC who underwent ESD from January 2020 to December 2020 at a single tertiary hospital (Daejeon, South Korea) were reviewed. Results: A total of 218 patients were enrolled and 29 had NSM (<3 mm). When comparing the NSM and the control groups, the size of the lesion, the depth of invasion, and the operating endoscopist were found to be risk factors for the development of NSM. The increased length of the subepithelial spread of the lesion was associated with a narrower safety margin. Logistic regression analysis revealed that lesion size was a risk factor for NSM, and a marginally significant difference between endoscopists was found. Conclusions: Multiple factors may need to be considered during ESD, including lesion size, invasion depth, operating endoscopist, and subepithelial spread.
Media Literacy and Its Implications for The Understanding of Truth and Reality: A Philosophical Exploration
Authors: Udoudom Uduak , George Kufre , Igiri Anthony , Aruku Kalita Joseph
Published: January 2024

In an era characterized by an overwhelming abundance of information and media channels, the concept of truth and reality has become increasingly complex. Media literacy, the ability to critically analyse, evaluate, and understand media messages, plays a crucial role in navigating this complexity. This paper explores the philosophical dimensions of media literacy and its implications for the understanding of truth and reality. Drawing on interdisciplinary perspectives from philosophy, communication studies, and cognitive science, this study investigates the intricate relationship between media literacy and the construction of truth and reality. By delving into various philosophical frameworks, including epistemology, ontology, and phenomenology, the research examined how individuals' media literacy skills shape their perceptions and interpretations of truth and reality. Additionally, the study examines how media literacy influences individuals' ontological understanding of reality. It explores how media messages shape and mediate individuals' perception of the world, examining the interplay between subjective experiences, social constructs, and media representations. Furthermore, the study investigated the potential for media literacy to foster a more nuanced understanding of reality, encouraging individuals to engage in critical reflexivity and challenge their preconceived notions. The findings of this study showed that media literacy plays a pivotal role in enhancing critical thinking skills and mitigating truth distortion in a post-truth society.
Legal Analysis in Mitigating Environmental Impacts Due to Coal Mining in Batanghari Regency, Jambi Province
Authors: Ternando Albi
Published: January 2024

Jambi Province is one of the provinces in Indonesia with natural mining wealth which contains many natural resource reserves. The processing of these natural resources has the potential to be managed as an energy source very well, such as the natural resources contained in it are coal. one of the areas in Kotoboyo village, Dalam subdistrict XXIV, Batanghari Regency, Jambi Province, is one of the largest coal producing areas in Indonesia, this area has been very productive in recent years, several coal mining companies have been located in the area, this does not necessarily mean that This means that the results of coal reserves can have a positive impact on the people who live in the surrounding area. In fact, there tends to be no visible environmental impact on the community. The mining activity process around the mine still uses national public road access, causing traffic jams that last for kilometers and disrupt traffic. crossing public roads in local communities, the Central, Regional Government and the Ministry of Energy and Mineral Resources should firmly work together to face the polemics that occur in the community as quickly as possible to provide solutions so that special road access to reduce the massive mobility of coal mining movements can be realized immediately for the prosperity of the community's economic movement.
Implementation Blessing Friday Movement Policy as Development of Social Capital
Authors: Madison  , Irwan  , Elvawati
Published: January 2024

MTSN 2 Solok School has carry out policy in the form of a Friday Movement program blessing. Research purposes This is analyze implementation Friday Movement policy blessing as development of the social model at MTS N 2 Solok. Study This use Lesser theory for analyze implementation Friday Movement policy blessing in development of social capital. Study This use approach qualitative with type study descriptive. The data collection method begins with observation, interview in depth and study document. Study analyzed with use Milles and Huberman analysis. Research result This showing that Friday Movement blessing can increase the strength of social capital on the part school with participant educate in aspect concern. Forms of social capital that are built is strengthen it solidarity fellow party school and its formation behavior togetherness for inhabitant school. This matter bring up attitude For each other help between One with others.
Workplace Stressors, Employee Welfare, and Productivity
Authors: Niere Marvin Ian E. , Mecon  , Narsico Lalaine O. , Narsico Peter G.
Published: January 2024

This study was about the delicate balance between employee well-being and organizational productivity. On the one hand, if work demand was too high, employees would be too stressed, and organizational productivity would be affected. On the other hand, if a workplace is too relaxed, the business may not survive. An optimal combination of employee well-being and organizational productivity had to be addressed in equal terms. The method used to identify potential workplace stressors was qualitative in as much as it made use of observations and interviews with informants. The method used to determine levels of workplace stressor experience of employees was descriptive-quantitative. This study made use of employee work stressor experience as leverage to highlight its dynamics with employee welfare and organizational productivity. Work stressors in the context of a fast-food establishment were identified. Employees were given survey questionnaires to determine the levels of workplace stressor experience. One-way ANOVA was used to determine the significance of the difference between workplace stressors, and subsequently, areas of intervention were identified. The conclusions were the following. Role conflict, role ambiguity, work overload, working conditions, and workplace relationships were identified as potential workplace stressors based on fast-food operations and settings. Identified workplace stressors were experienced by employees at varying levels. There was a significant difference between workplace stressors. Interventions were to include all identified stressors beginning with the most prevalent, work overload. Areas of intervention included social and organizational support, employee stress-coping attitudes and skills, work performance abilities, and work-life balance.
Exploring Challenges and Opportunities: Evaluating the Awareness and Readiness of Selected Government Agencies in Adopting Artificial Intelligence (AI)
Authors: Campued Jake C. , Papa Dorothy-May M. , De Castro Armstrong C. , Malang Bernandino P.
Published: January 2024

This study undertakes a comprehensive examination of the awareness, skills, attitude, and readiness of respondents regarding the adoption of Artificial Intelligence (AI) applications in their professional settings. While the research evaluates respondents' familiarity with AI tools, proficiency levels, and overall attitude towards AI integration, it also strives to present a nuanced perspective by exploring potential challenges and reservations. The data, collected through a structured survey employing a Likert scale, captures diverse viewpoints on awareness, skills, attitude, and readiness towards AI applications. The findings reveal a generally positive outlook among respondents, emphasizing their commendable awareness of AI technologies and a strong inclination towards potential benefits. Despite varying levels of proficiency with specific AI tools, respondents express a collective willingness to embrace new technologies. The study identifies a positive attitude towards AI integration in work processes, accompanied by a proactive approach towards skill development and troubleshooting. However, it is crucial to note the potential challenges and reservations reported by some respondents, offering a balanced view of their preparedness for AI adoption. While the overall disposition towards AI technologies is favorable, the study underscores the importance of tailored training and development programs. The varying levels of proficiency reported highlight the need for targeted initiatives to address specific skill gaps. Organizations aiming to leverage AI technologies can benefit from the insights provided, emphasizing the significance of accessible training and creating a supportive environment for employees. By acknowledging challenges and reservations, this study contributes to a more comprehensive understanding of the landscape, facilitating informed strategies for successful AI integration in the workplace.
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis
Authors: Lv Jian-Jun , Wang Hao , Zhang Cong , Zhang Tian-Jiao , Wei Hao-Lin , Liu Ze-Kun , Ma Yi-Hui , Yang Zhi , He Qian , Wang Li-Juan , Duan Li-Li , Chen Zhi-Nan , Bian Huijie
Published: January 2024

BACKGROUND:

Atherosclerosis is a globally prevalent chronic inflammatory disease with high morbidity and mortality. The development of atherosclerotic lesions is determined by macrophages. This study aimed to investigate the specific role of myeloid-derived CD147 (cluster of differentiation 147) in atherosclerosis and its translational significance.

METHODS AND RESULTS:

We generated mice with a myeloid-specific knockout of CD147 and mice with restricted CD147 overexpression, both in an apoE-deficient (ApoE
–/–
) background. Here, the myeloid-specific deletion of CD147 ameliorated atherosclerosis and inflammation. Consistent with our in vivo data, macrophages isolated from myeloid-specific CD147 knockout mice exhibited a phenotype shift from proinflammatory to anti-inflammatory macrophage polarization in response to lipopolysaccharide/IFN (interferon)-γ. These macrophages demonstrated a weakened proinflammatory macrophage phenotype, characterized by reduced production of NO and reactive nitrogen species derived from iNOS (inducible NO synthase). Mechanistically, the TRAF6 (tumor necrosis factor receptor–associated factor 6)-IKK (inhibitor of κB kinase)-IRF5 (IFN regulatory factor 5) signaling pathway was essential for the effect of CD147 on proinflammatory responses. Consistent with the reduced size of the necrotic core, myeloid-specific CD147 deficiency diminished the susceptibility of iNOS-mediated late apoptosis, accompanied by enhanced efferocytotic capacity mediated by increased secretion of GAS6 (growth arrest–specific 6) in proinflammatory macrophages. These findings were consistent in a mouse model with myeloid-restricted overexpression of CD147. Furthermore, we developed a new atherosclerosis model in ApoE
–/–
mice with humanized CD147 transgenic expression and demonstrated that the administration of an anti-human CD147 antibody effectively suppressed atherosclerosis by targeting inflammation and efferocytosis.

CONCLUSIONS:

Myeloid CD147 plays a crucial role in the growth of plaques by promoting inflammation in a TRAF6-IKK-IRF5–dependent manner and inhibiting efferocytosis by suppressing GAS6 during proinflammatory conditions. Consequently, the use of anti-human CD147 antibodies presents a complementary therapeutic approach to the existing lipid-lowering strategies for treating atherosclerotic diseases.
Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease
Authors: Grubman Scott , Algara Miguel , Smolderen Kim G. , Luna Paulina , Walenczyk Kristie , Scierka Lindsey , Cleman Jacob , Siddiqui Waleed Tariq , Romain Gaëlle , Mena‐Hurtado Carlos
Published: January 2024

Background

Peripheral artery disease (PAD) and microvascular disease (MVD) are highly prevalent conditions that share common risk factors. This observational study aimed to characterize patients with both conditions and determine the impact of comorbid PAD/MVD on outcomes.

Methods and Results

Patients admitted across 31 states January 2011 through December 2018 with a primary or secondary diagnosis of PAD or MVD were included from the National Readmissions Database and weighted to approximate a national sample. Those age <18 years or with nonatherosclerotic leg injuries were excluded. Patients were divided into 3 groups: PAD‐only, MVD‐only, or comorbid PAD/MVD. Multiple logistic regression was used to evaluate associations with major and minor amputations, major adverse cardiac events, and in‐hospital mortality. Cox regression was used to evaluate associations with readmission within 1 year. The PAD group was used as reference. The final cohort included 33 972 772 admissions: 9.1 million with PAD, 21.3 million with MVD, and 3.6 million with both. Annual admissions for PAD/MVD increased to >500 000 in 2018. Major and minor amputations increased ≈50% for PAD/MVD between 2011 and 2018. Compared with PAD‐only, PAD/MVD was associated with a higher risk for major amputation (odds ratio [OR], 1.30 [95% CI, 1.28–1.32]), minor amputation (OR, 2.15 [95% CI, 2.12–2.18]), major adverse cardiac events (OR, 1.04 [95% CI, 1.03–1.04]), in‐hospital mortality (OR, 1.07 [95% CI, 1.05–1.09]), and readmission (hazard ratio, 1.02 [95% CI, 1.02–1.02]) after adjustment for baseline factors.

Conclusions

Comorbid MVD is present in a large and growing number of patients with PAD and is associated with augmented risk for adverse outcomes. Further prospective research is merited to understand this vulnerable population.
“Sketching With My Mind”: The Role of Prior Intentions and Intentions in Action for the Creative Process of Design
Authors: Mendoza-Collazos Juan , van de Weijer Joost
Published: January 2024

This study investigates the effects of prior intentions and intentions in action during the initial stage of a process of design in search of correlations between these cognitive processes and the quality of the design outcomes. We found that the quality of the outcomes was not influenced by sketching. Nevertheless, most of the participants said that they preferred sketching, and their verbal reports can be seen as indicative of the formation of prior intentions. Therefore, we argue that prior intentions have an important role even within a process of pure material engagement. This has important implications for understanding the active role of human agency and our capacity to form prior intentions with pragmatic effects in the world.
Ochradenus lakhpatensis (Resedaceae), a new species from Gujarat, India
Authors: PATEL ROHITKUMAR M. , PRAJAPATI SUJITKUMAR R. , MARTÍN-BRAVO SANTIAGO
Published: January 2024

A new species of the genus Ochradenus (Resedaceae), O. lakhpatensis, is described and illustrated. It is known from just five populations endemic to a relatively restricted area in Western India (Gujarat state), constituting the easternmost known records of the genus. It is morphologically similar to O. harsusiticus but differs in having pedicellate flowers and fruits, a higher number of stamens, wider fruit, and open fruit apex. A detailed description of the new species including colour photographs and an identification key to distinguish currently accepted Ochradenus species are provided. A preliminary conservation assessment of the species is also conducted under IUCN categories and criteria at the global level, resulting in the proposal of the Endangered category. In addition, we propose the exclusion of O. baccatus from the Indian flora, as it seems to be erroneous record.
Typifications in Piper consanguineum (Piperaceae)
Authors: MELO ALINE , ALVES MARCCUS
Published: January 2024

During studies of Piperaceae in Northeastern Brazil, we found names lacking designated type material, among them Piper consanguineum. We revised the synonyms, protologues and bibliographies where names have been cited. A neotype has been designated for Piper consanguineum (Kunth) Steud., as well as a lectotype for Piper surinamense C. DC., which also had a syntype excluded from its name.
History Under Censorship: Józef Piłsudski’s Eastern Policy in Polish Marxist Historiography (1945–1989)
Authors: Borymskyi Vitalii
Published: January 2024

The article examines the historiography and history policy in the communist Polish People’s Republic (1945–1989) regarding the Eastern policy of Józef Piłsudski. Poland was one of the most important countries in the socialist camp, and it had a complicated history of relations with the USSR. Under Moscow’s influence, Poland had to adapt its official history to the Soviet one. This was especially difficult to accomplish considering recent hostile Polish-Soviet relations. Consequently, implementing such a history policy was a complex and uneven process. Piłsudski’s policy was treated extremely negatively during the Stalinist period, a view that softened in subsequent years under the influence of a gradual liberalisation of the history policy of the state. Although the general interpretation of Piłsudski’s Eastern policy remained negative until 1989, it became significantly different from Soviet dogmas. The source of this study were both propaganda texts, professional historiography and historical essays.
Regional Features in the Phrasematics of Novellas Submitted to a Competition Organised by the Kaunas Daily “Dzień Polski” (1936)
Authors: Mędelska Jolanta , Marszałek Marek
Published: January 2024

This article analyses 33 phrasemes used in the Northern Borderland variety of Polish, which were extracted from about 20 novellas submitted to the competition announced in 1936 by Dzień Polski [The Polish Day], a Polish daily issued in Kaunas. The study classifies the extracted multiword units into substrate-interference units (formed under the influence of the Belarusian-Lithuanian substrate and more recent interference from Russian and Lithuanian) and archaic-innovative units (outdated and modified without foreign influence). The descriptions of individual phrasemes follow a standardised pattern. Substrate-interference phrasemes account for 70% of the material (9 substrate phrasemes, e.g. wiatry w głowie or durzyć głowę, and 14 interference phrasemes, mainly of Russian origin, e.g. jak na zło or podać prośbę), and 30% are native units (8 obsolete, e.g. zakasać ręce or beczka łoju = góra sadła, 1 local innovation: wyrządzić scenę zazdrości, and 1 phraseme common to indigenous Polish dialects: mieć gdziesik). The phrasematics of the Kaunas novellas makes an addition to the still modest list of multiword units in the Northern Borderland variety of Polish.
Design, Characterization, and Bioanalytical Applications of Green Terbium- and Nitrogen-Doped Carbon Quantum Dots as a Fluorescent Nanoprobe for Omadacycline Analysis
Authors: Salman Baher I. , Hassan Ahmed I. , Batakoushy Hany A. , Saraya Roshdy E. , Abdel-Aal Mohamed A. A. , Al-Harrasi Ahmed , Ibrahim Adel Ehab , Hassan Yasser F.
Published: January 2024

Terbium- and nitrogen-doped carbon quantum dots (Tb,N@CQDs) were greenly created employing microwave synthesis from plum juice with terbium nitrate. The synthesis of Tb,N@CQDs was fast (7 min) with a high quantum yield (35.44%). Tb,N@CQDs were fully characterized using transmission electron microscopy, Zeta potential analysis, fluorescence, and ultraviolet spectroscopy. Omadacycline (OMC) is a broad-spectrum tetracycline that has been recently approved by the United States Food and Drug Act (FDA) in October 2018. OMC is the first oral aminomethylcycline class antibiotic drug that was authorized for the treatment of acute skin structure infections and community-acquired pneumonia. Tb,N@CQDs exhibited emission at 440 nm after excitation at 360 nm, where their fluorescence intensity showed a reduction upon addition of OMC. The experimental parameters were further studied and optimized. The linear range was between 40 and 60 parts per billion (ppb), with (limit of quantitation) equal to 34.78 ppb. The proposed approach was validated for bioanalytical purposes using FDA guidelines and proved to be straightforward, cheap, highly sensitive, and very selective, which can be used in clinical studies. The developed approach proved to be green using some current assessment metrics and was applied successfully for the determination of OMC in human plasma, milk, and pharmaceutical formulations as well as pharmacokinetic study.
What Aimed Movement Models Fit Distal Pointing With Varying Depth?
Authors: Wang Yuqian , Goonetilleke Ravindra S. , Lin Ray F.
Published: January 2024

Objective

With the rapid improvements in drone technology, there is an increasing interest in distal pointing to diffuse drones. This study investigated the effect of depth on distal pointing when the hand does not traverse the entire distance from start to target so that the most suitable mathematical model can be assessed.

Background

Starting from the Fitts paradigm, researchers have proposed different models to predict movement time when the distance to the target is variable. They do consider distance, but they are based on statistical modeling rather than the underlying control mechanisms.

Methods

Twenty-four participants volunteered for an experiment in a full-factorial Fitts’ paradigm task (3 levels of movement amplitude *7 levels of target width *3 levels of distance from participant to screen). Movement time and the number of errors were the dependent variables.

Results

Depth has a significant effect when the target width is small, but depth has no effect when the target width is large. The angular version of the two-part model is superior to the one-part Fitts’ model at larger distances. Besides, Index of difficulty for distal pointing, [Formula: see text] with adjustable k achieves the best fit even though the model is very sensitive to the value of k and the complexity of the model could be resulting in an overfitting. The result implies that the effects of movement amplitude and target width are not comparable and grouping them to form a dependent index of difficulty can be misleading especially when distance is an added variable.

Conclusion

The angular version of the two-part model is a viable and meaningful description for distal pointing. Even though the [Formula: see text] with adjustable k is the best predictor for movement time when depth is an added variable, there is no physical interpretation for it.

Application

A reasonable predictive model for performance assessments and predictions in distal pointing.
Refusal and Acceptance in Reciprocal Social Exchange
Authors: Whitham Monica M. , Savage Scott V.
Published: January 2024

In this article, we apply a social exchange theoretical approach to the study of rejection. We investigate how the explicit refusal and acceptance of offered resources affect reciprocal exchanges. We distinguish contexts with explicit communication of refusal from contexts in which refusal is uncommunicated or concealed and investigate how context and the actual experience of refusal affect reciprocal social exchange behaviors and the emergence of social bonds. We also examine the effects of contexts and experiences of communicated acceptance. Results of a controlled laboratory experiment show that the contextual possibility of refusal increases giving but nevertheless weakens emerging social bonds. Experiencing refusal increases self-isolation but also, under certain conditions, greater investment in alternative relationships. The contextual possibility of acceptance, on the other hand, has little effect on giving behaviors or social bonds. The experience of acceptance, however, may reduce partner switching.
Empirical Analysis of Energy Consumption and Economic Growth in Post-Soviet Eurasia: Do They Matter for Foreign Policy?
Authors: Aksoy Metin , Mangir Fatih , Sümer Vakur
Published: January 2024

This study aims to evaluate the relationship between renewable and non-renewable energy consumption and economic growth in post-Soviet Eurasian countries by employing panel data from 15 countries from 1996 to 2018. The results reveal that the contribution of renewable energy consumption (REC) to economic growth is greater than non-renewable energy consumption. The overall findings imply that the transformation of energy consumption from non-renewable to renewable offers environmental advantages and growth opportunities. Furthermore, the transition to renewables may also expand the range of foreign relations policy options available for these countries, which, in turn, might contribute to a better alignment with evolving global regimes. Transition demands towards the long-term sustainability of global energy sources put pressure on countries to expand their domestic policy efforts and join international cooperation efforts. Therefore, post-Soviet Eurasian countries should develop strategic policy mechanisms and reforms designed to accelerate investments in renewable energy technologies.
Endoscopic Retrieval of a Transpalatal Arch as an Orthodontic Emergency: A Case Report
Authors: Sharif Mohammad , Antil A. , Ray S. , Thapa A.
Published: January 2024

Ingestion of a foreign object forms a potential complication, be it any branch of dentistry. The present article describes an incident of accidental foreign body ingestion by an orthodontic patient while trying to consume a firm Indian delicacy leading to fracture, and eventual swallowing of a Transpalatal arch. The case was immediately referred to Department of Gastroenterology, wherein the major part of fractured arch was retrieved endoscopically from stomach while the minor part’s trajectory was followed on subsequent radiographs until it was eliminated. This report concludes in the management and further discussion of possible clinical complications, causes, and practices for prevention.
Comparative Evaluation of Molar Distalization Between Pendulum Appliance and Miniscrew Anchorage System: A Clinical Study
Authors: Sharma Sameer , Singla Anil , Mahajan Vivek , Jaj Harupinder Singh , Dhiman Indu
Published: January 2024

Introduction:

Molar distalization is one of the treatment protocols in cases with mild to moderate arch discrepancy and class II molar relationship associated with a normal mandible. It is achieved by using pendulum appliance and temporary anchorage devices such as miniscrew anchorage system.

Aims and Objectives:

To evaluate and compare the dentoalveolar and skeletal changes between pendulum appliance and miniscrew anchorage system.

Materials and Methods:

The patients were divided into 2 groups of 10 each: group I (using the pendulum appliance) and group II (using miniscrew anchorage system). Lateral cephalogram was taken for each subject and various skeletal such as SNA, SNB, ANB, and PTV-A dentoalveolar (U1-PTV, U6-PTV, U5-FH, and U6-FH) measurements were taken. The data obtained were statistically analyzed using Statistical Package for Social Sciences (SPSS) software. Intragroup analysis between pendulum and implant group was done using Wilcoxon Matched pairs test and the intergroup analysis between pendulum and implant group was done using Mann–Whitney test.

Results:

The results showed that there was nonsignificant difference in both the groups ( p > .05) with the less tipping in group II (1.2) than group I (2.7) .The molar extrusion was more with the pendulum group (2.1 mm) than the miniscrew anchorage distalization group (1.3 mm).

Conclusion:

The molar distalization using the miniscrew anchorage system showed more bodily movement than the pendulum appliance which showed more tipping movement. Moreover, the pendulum appliance showed significant amount of anchor loss than the miniscrew anchorage system.
Biomaterials for bone defect repair: Types, mechanisms and effects
Authors: Wang Jiaming , Liu Mingchong , Yang Chensong , Pan Yutao , Ji Shengchao , Han Ning , Sun Guixin
Published: January 2024

Bone defects or bone discontinuities caused by trauma, infection, tumours and other diseases have led to an increasing demand for bone grafts and biomaterials. Autologous bone grafts, bone grafts with vascular tips, anastomosed vascular bone grafts and autologous bone marrow components are all commonly used in clinical practice, while oversized bone defects require the use of bone tissue engineering-related biomaterials to repair bone defects and promote bone regeneration. Currently, inorganic components such as polysaccharides and bioceramics, as well as a variety of bioactive proteins, metal ions and stem cells can be loaded into hydrogels or 3D printed scaffold materials to achieve better therapeutic results. In this review, we provide an overview of the types of materials, applications, potential mechanisms and current developments in the repair of bone defects.
Public Sector Collective Bargaining: A Meta-Review
Authors: Federman Peter Stanley , Viswanath Shilpa , Riccucci Norma M.
Published: January 2024

Public sector labor unions and their commitment to collective bargaining are central to the study of public sector human resource management. This study explores collective bargaining scholarship in the United States as exemplified in the public administration literature. Systematically coding 220 articles from the top fifteen (mainstream) peer-reviewed public administration journals over a period of 50 years (1970–2020), this study examines how public sector collective bargaining is framed and conceptualized in public administration research, identifying, and studying the dimensions of public sector collective bargaining research in the United States. The primary purpose of this article is to map trends and gaps in local, state, and federal public sector collective bargaining scholarship, which is an essential public personnel function in need of further academic attention. It is also hoped that this study could stimulate future research into public sector collective bargaining.
Coding With Robots or Tablets? Effects of Technology-Enhanced Embodied Learning on Preschoolers’ Computational Thinking and Social-Emotional Competence
Authors: Yang Weipeng
Published: January 2024

Computational Thinking (CT) is essential for developing creativity, problem-solving, and digital competence in the 21st century. Coding tools like robotic toys and tablet apps have become popular in early childhood education to support CT development, but there is a debate on which tool is more effective. Little evidence exists on the effect of coding on children’s Social-Emotional Competence (SEC), which is crucial for lifelong development and extends beyond cognitive development. This experimental study aimed to compare the effectiveness of two 9-week programs on promoting 73 preschool children’s CT and SEC, one using coding robots and the other using coding apps. The results showed that children who participated in the Coding Robot Program had higher CT scores than those in the Coding App Program, after controlling for age, gender, family socioeconomic status, and baseline CT scores. While the SEC scores showed no substantial disparities between the groups, it was revealed that the initial performance levels moderated the intervention effects on emotional regulation and overall SEC. This suggests that the Coding Robot Program could be especially advantageous for a subset of children who initially have difficulties with emotional regulation and social skills. Implications of this study are presented for research and practice.
Risk assessment—based verification of the CertiPURTM limit values for toluene diamine and methylene dianiline in flexible polyurethane foam
Authors: de Kort Patrick , Jensen Elke , Spence Mark W , Plehiers Patrick M
Published: January 2024

Flexible polyurethane foams (PUF) are used in many consumer products. PUF may contain trace levels of aromatic diamine impurities that could represent a potential health risk. The risk associated with sleeping on a PUF mattress was evaluated. Toxicity benchmarks for sensitization and non-cancer endpoints were derived from the respective points-of-departure using standard assessment factors. For the cancer endpoints, toxicity benchmarks were derived from the 25th-percentile values of animal studies. Recently published emission and migration data allowed to link exposure with the CertiPURTM voluntary quality limits of ≤5 mg.kg−1 for 2,4-toluene diamine and 4,4’-methylene dianiline in PUF. Using conservative exposure scenarios, lifetime-average daily internal doses from the combined inhalation and dermal exposures were calculated. Margins of safety for non-cancer and sensitization endpoints were >104. The theoretical excess cancer risk was ≤1.5 × 10−7. It is concluded that sleeping on a mattress that satisfies the CertiPUR limit value does not pose undue risk to consumers.
Preparation and mechanical properties of Ni/RGO reinforced epoxy resin composites
Authors: Yang Xinjia , Song Keru , Zhao Dongyu
Published: January 2024

The graphene/nanonickel composites(Ni/RGO) were prepared by liquid phase reduction method, and the graphene/nanonickel epoxy composites(Ni/RGO/EP) were prepared by in-situ polymerization method. The glass transition temperature (Tg) of the modified epoxy resin was increased by 19°C compared to EP with 2.1 wt% Ni/RGO loading. The tensile strength and hardness increased by 65% and 18%, the impact strength is increased by 10.053 KJ·m−2 compared to EP, and the shear strength reaches 34.78 MPa for the Ni/RGO/EP with 1.7 wt% Ni/RGO loading. It can be seen, that the addition of Ni/RGO greatly improves the heat resistance and mechanical properties of epoxy resin when the Ni/RGO are evenly dispersed into the epoxy resin by emulsion dispersion method.
Statistical modelling and process optimization of EDM electrode fabricated using pressureless microwave sintering and rapid tooling route
Authors: Arya Shitanshu , Pandey Pulak Mohan
Published: January 2024

The fabrication of customized products necessitates specialized setups, such as tools and dies, capable of accommodating complex shapes. In the present work, rapid tooling, an indirect 3D printing process along with pressureless microwave sintering was employed to fabricate complex shaped electric discharge machine (EDM) electrode. Copper spherical particles were used as the material for sample fabrication, and central composite design technique was utilized to conduct experiments. The investigation focused on exploring the impact of microwave sintering machine parameters – sintering temperature, heating rate and holding time – on crucial electrode properties, including density, volumetric shrinkage and electrical conductivity. The dominance of the sintering temperature on responses was revealed over the heating rate and holding time. Additionally, the effect of interaction between heating rate and holding time on electrical conductivity and density showed less effect of large holding time at slower heating rate. To investigate the particle bonding behaviour, scanning electron micrographs of the fabricated samples were also studied. The adopted methodology effectively sintered the particles without the need for applying pressure. Using genetic algorithm (GA), a multi-objective optimization was conducted to achieve an optimized set of microwave sintering machine parameters, aiming for maximum density, electrical conductivity and minimum volumetric shrinkage. A density of 7.32 g/cc, volumetric shrinkage of 8.36% and electrical conductivity of 73.88% IACS was obtained from samples sintered at optimized sintering parameters. The dimensions of the fabricated electrodes and machined cavity were then compared with the computer-aided design model. The results revealed an efficient process for fabricating complex shaped EDM electrodes.
Overhead crane bridge structure design optimization based on safety assessment
Authors: He Bin , Zhao Zhangyan , Qiu Faju
Published: January 2024

In order to achieve safe and economical design results for crane bridge structures, an optimization method with safety assessment constraints is proposed. In this approach, the limit state method is used to test the structure design. Safety assessment is conducted based on the fuzzy analytic network process, allowing the safety score of designs to be quantified. Aiming to minimize the self-weight of the bridge, the dimensions of critical sections are regarded as design variables and constraints related to the process size, strength, stiffness, stability, and safety score are imposed, utilizing the artificial hummingbird algorithm for the structure optimal design. After validating through an engineering example, the results demonstrated that under the settled safety constraints, the proposed optimization method successfully reduced the structural self-weight by 19.709%, while maintaining a safety score proximate to the original design. In comparison to optimization without safety assessment constraints, this method resulted in a 10.441% increase in weight, but its safety was significantly improved by 21.740%. This validates the effectiveness and practicality of incorporating safety assessment into structure optimization, thereby ensuring a balanced trade-off between safety and material economy in the design of crane bridge structures.