bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypothermia combined with neuroprotective adjuvants shortens the duration of hospitalization in infants with hypoxic ischemic encephalopathy: Meta-analysis
Authors: Ovcjak Andrea , Pontello Riley , Miller Steve P. , Sun Hong-Shuo , Feng Zhong-Ping
Published: January 2023

Objective: Therapeutic hypothermia (TH) is the current standard of care for neonatal hypoxic-ischemic encephalopathy (HIE), yet morbidity and mortality remain significant. Adjuvant neuroprotective agents have been suggested to augment hypothermic-mediated neuroprotection. This analysis aims to identify the classes of drugs that have been used in combination with hypothermia in the treatment of neonatal HIE and determine whether combination therapy is more efficacious than TH alone.

Methods: A systematic search of PubMed, Embase and Medline from conception through December 2022 was conducted. Randomized- and quasi-randomized controlled trials, observational studies and retrospective studies evaluating HIE infants treated with combination therapy versus TH alone were selected. Primary reviewers extracted information on mortality, neurodevelopmental impairment and length of hospitalization for meta-analyses. Effect sizes were pooled using a random-effects model and measured as odds ratio (OR) or mean difference (MD) where applicable, and 95% confidence intervals (CI) were calculated. Risk of bias was assessed using the tool from the Cochrane Handbook for Systematic Reviews of Interventions.

Results: The search strategy collected 519 studies, 16 of which met analysis inclusion criteria. HIE infants totaled 1,288 infants from included studies, 646 infants received some form of combination therapy, while 642 received TH alone. GABA receptor agonists, NMDA receptor antagonists, neurogenic and angiogenic agents, stem cells, glucocorticoids and antioxidants were identified as candidate adjuvants to TH that have been evaluated in clinical settings compared to TH alone. Length of hospitalization was significantly reduced in infants treated with combination therapy (MD −4.81, 95% CI [−8.42. to −1.19], p = .009) compared to those treated with TH alone. Risk of mortality and neurodevelopmental impairment did not differ between combination therapy and TH alone groups.

Conclusion: Compared to the current standard of care, administration of neuroprotective adjuvants with TH reduced the duration of hospitalization but did not impact the risk of mortality or neurodevelopmental impairment in HIE infants. Meta-analysis was limited by a moderate risk of bias among included studies and small sample sizes. This analysis highlights the need for preclinical trials to conduct drug development studies in hypothermic settings to identify relevant molecular targets that may offer additive or synergistic neuroprotection to TH, and the need for larger powered clinical trials to determine the dose and timing of administration at which maximal clinical benefits are observed for adjuvant neuroprotectants.
A high-precision bidirectional time-transfer system over a single fiber based on wavelength-division multiplexing and time-division multiplexing
Authors: Guo Xinxing , Liu Bo , Kong Weicheng , Quan Honglei , Zhang Yucan , Liu Tao , Dong Ruifang , Zhang Shougang
Published: January 2023

In this paper, a high-precision bidirectional time-transfer system over a single fiber based on wavelength-division multiplexing and time-division multiplexing (SFWDM-TDM) is proposed, which combines the advantages of wavelength-division multiplexing and time-division multiplexing. It uses two dense wavelength-division channels to effectively suppress the problem of optical fiber reflection. At the same time, the time-division multiplexing method is used in combination with sampling and holding the time to complete the multi-user task. In hardware, we optimized the carrier processing and the high-precision time-delay control module of the SFWDM-TDM system to complete high-precision time-transfer equipment. In software and algorithm, the optical fiber time-interval measurement method and measurement times are optimized, and the SFWDM-TDM system reaches a synchronization accuracy of 8.9 ps at 1 s. Finally, a real-time detection mechanism with self-recovery ability is added to the system. This lays the foundation for a reliable, long-distance, high-precision, and multi-user mode optical fiber time- and frequency-transfer network.
Spatiotemporal shaping of high power laser pulses based on stimulated brillouin scattering
Authors: Zhu Xuehua , Liu Chuangchuang , Gao Qilin , Su Hao , Sun Sizhou
Published: January 2023

We proposed and numerically demonstrated the combination of temporal and spatial shaping of high power nanosecond laser pulses based on stimulated Brillouin scattering (SBS) in this paper. With the intensity-dependence characteristic of SBS, the higher intensity parts of the laser beam obtain higher reflectivity, and the incident non-uniform high power laser beam would be well smoothed. A parameter adjustable feedback control loop was used to tailor the output temporal profile by pre-compensating the temporal profile of the input pump. In our numerical simulation, a 3 ns super-Gaussian shaped single-frequency laser pulse with a 527 nm wavelength was used as the pump. And the heavy fluorocarbon FC-70 was chosen as the Brillouin medium. Simulation results show that the laser spatial modulation can be significantly pulled down when the energy efficiency is maintained above 90% in our beam smoothing system with suitable laser intensity. The flat-toped laser pulses both in temporal and spatial domain were demonstrated to be achievable simultaneously. The method proposed here paves a simple and effective way to optimizing the near field pattern and temporal shape of high power laser systems.
Calcium-sensing receptor-mediated NLRP3 inflammasome activation in rheumatoid arthritis and autoinflammation
Authors: Werner Lina Emilia , Wagner Ulf
Published: January 2023

The calcium-sensing receptor (CaSR) is expressed in many cell types – including immune cells and in particular circulating monocytes. Here, the receptor plays an important physiological role as a regulator of constitutive macropinocytosis. This review article provides an overview of the literature on the role of the calcium sensing receptor in the context of inflammatory processes. Special emphasis is laid upon the importance for monocytes in the context of rheumatoid arthritis. We have shown previously, that stimulation of the receptor by increased extracellular Ca2+ ([Ca2+]ex) triggers a pro-inflammatory response due to NLRP3 inflammasome assembly and interleukin (IL)-1β release. The underlying mechanism includes macropinocytosis of calciprotein particles (CPPs), which are taken up in a [Ca2+]ex-induced, CaSR dependent manner, and leads to strong IL-1β release. In rheumatoid arthritis (RA), this uptake and the resulting IL-1β release is significantly increased due to increased expression of the receptor. Moreover, increased [Ca2+]ex-induced CPP uptake and IL-1β release is associated with more active disease, while CaSR overexpression has been reported to be associated with cardiovascular complications of RA. Most importantly, however, in animal experiments with arthritic mice, increased local calcium concentrations are present, which in combination with release of fetuin-A from eroded bone could contribute to formation of CPPs. We propose, that increased [Ca2+]ex, CPPs and pro-inflammatory cytokines drive a vicious cycle of inflammation and bone destruction which in turn offers new potential therapeutic approaches.
Aortic valve morphology and paravalvular leak regression after a self-expandable transcatheter aortic valve replacement
Authors: Jin Qinchun , Li Wei , Chen Shasha , Li Mingfei , Zhou Daxin , Zhang Xiaochun , Ge Junbo
Published: January 2023

Aims: The study aimed to compare paravalvular leak (PVL) changes after a transcatheter aortic valve replacement (TAVR) with self-expandable prosthesis between different aortic valve morphologies and evaluate the impact of paravalvular leak regression on clinical prognosis.

Methods: Patients with aortic stenosis (AS) successfully treated with a self-expandable TAVR who were followed up for at least 1 year at our centre were consecutively enrolled from January 2016 to August 2019. Paired serial changes in paravalvular leak and other haemodynamic parameters by echocardiography were collected and compared between the bicuspid valve (BAV) and tricuspid aortic valve (TAV). A logistic regression model was used to explore the predictors of paravalvular leak regression (<1 grade) 1 year after transcatheter aortic valve replacement, while its impact on subsequent clinical outcomes (all-cause mortality and rehospitalisation for heart failure (HF)) was further evaluated using Kaplan–Meier analysis.

Results: A total of 153 bicuspid valve and 114 tricuspid aortic valve patients were finally enrolled; haemodynamic parameters and paravalvular leak severity were comparable before the discharge between the two groups. The peak transaortic velocity, mean transvalvular gradient, and effective orifice area all significantly improved (p < 0.05) without intergroup differences at all follow-up timepoints. Significant paravalvular leak reduction was observed only in the TAV group (1.75% vs. 4.39%, p = 0.029), while moderate paravalular leak was still more prevalent in BAV (7.19% vs. 1.75%, p = 0.041) at the 1-year follow-up. Multivariable analyses identified the bicuspid valve, asymmetric calcification, and undersizing as independent predictors of failure of the 1-year paravalvular leak reduction in patients with mild or moderate paravalvular leak after discharge. Patients without a paravalvular leak reduction within 1 year showed a relatively higher 2-year all-cause mortality and HF (HR: 5.994, 95% CI: 1.691–21.240, and p = 0.053) rates thereafter.

Conclusion: In AS patients after self-expandable transcatheter aortic valve replacement, paravalvular leak regression within 1 year was less prevalent in bicuspid valve morphology. The failure of paravalvular leak reduction might lead to an increased risk of poorer prognosis in the long run.
Multiple aspects of lymphatic dysfunction in an ApoE−/− mouse model of hypercholesterolemia
Authors: Davis Michael J. , Scallan Joshua P. , Castorena-Gonzalez Jorge A. , Kim Hae Jin , Ying Lim Hwee , Pin Yeo Kim , Angeli Veronique
Published: January 2023

Introduction: Rodent models of cardiovascular disease have uncovered various types of lymphatic vessel dysfunction that occur in association with atherosclerosis, type II diabetes and obesity. Previously, we presented in vivo evidence for impaired lymphatic drainage in apolipoprotein E null (ApoE−/−) mice fed a high fat diet (HFD). Whether this impairment relates to the dysfunction of collecting lymphatics remains an open question. The ApoE−/− mouse is a well-established model of cardiovascular disease, in which a diet rich in fat and cholesterol on an ApoE deficient background accelerates the development of hypercholesteremia, atherosclerotic plaques and inflammation of the skin and other tissues. Here, we investigated various aspects of lymphatic function using ex vivo tests of collecting lymphatic vessels from ApoE+/+ or ApoE−/− mice fed a HFD.

Methods: Popliteal collectors were excised from either strain and studied under defined conditions in which we could quantify changes in lymphatic contractile strength, lymph pump output, secondary valve function, and collecting vessel permeability.

Results: Our results show that all these aspects of lymphatic vessel function are altered in deleterious ways in this model of hypercholesterolemia.

Discussion: These findings extend previous in vivo observations suggesting significant dysfunction of lymphatic endothelial cells and smooth muscle cells from collecting vessels in association with a HFD on an ApoE-deficient background. An implication of our study is that collecting vessel dysfunction in this context may negatively impact the removal of cholesterol by the lymphatic system from the skin and the arterial wall and thereby exacerbate the progression and/or severity of atherosclerosis and associated inflammation.
Association mapping for broomrape resistance in sunflower
Authors: Calderón-González Álvaro , Pérez-Vich Begoña , Pouilly Nicolas , Boniface Marie-Claude , Louarn Johann , Velasco Leonardo , Muños Stéphane
Published: January 2023

Introduction

Sunflower breeding for resistance to the parasitic plant sunflower broomrape (Orobanche cumana Wallr.) requires the identification of novel resistance genes. In this research, we conducted a genome-wide association study (GWAS) to identify QTLs associated with broomrape resistance.

Methods

The marker-trait associations were examined across a germplasm set composed of 104 sunflower accessions. They were genotyped with a 600k AXIOM® genome-wide array and evaluated for resistance to three populations of the parasite with varying levels of virulence (races EFR, FGV, and GTK) in two environments.

Results and Discussion

The analysis of the genetic structure of the germplasm set revealed the presence of two main groups. The application of optimized treatments based on the general linear model (GLM) and the mixed linear model (MLM) allowed the detection of 14 SNP markers significantly associated with broomrape resistance. The highest number of marker-trait associations were identified on chromosome 3, clustered in two different genomic regions of this chromosome. Other associations were identified on chromosomes 5, 10, 13, and 16. Candidate genes for the main genomic regions associated with broomrape resistance were studied and discussed. Particularly, two significant SNPs on chromosome 3 associated with races EFR and FGV were found at two tightly linked SWEET sugar transporter genes. The results of this study have confirmed the role of some QTL on resistance to sunflower broomrape and have revealed new ones that may play an important role in the development of durable resistance to this parasitic weed in sunflower.
A metabolomic platform to identify and quantify polyphenols in coffee and related species using liquid chromatography mass spectrometry
Authors: Castro-Moretti Fernanda R. , Cocuron Jean-Christophe , Castillo-Gonzalez Humberto , Escudero-Leyva Efrain , Chaverri Priscila , Guerreiro-Filho Oliveiro , Slot Jason C. , Alonso Ana Paula
Published: January 2023

Introduction

Products of plant secondary metabolism, such as phenolic compounds, flavonoids, alkaloids, and hormones, play an important role in plant growth, development, stress resistance. The plant family Rubiaceae is extremely diverse and abundant in Central America and contains several economically important genera, e.g. Coffea and other medicinal plants. These are known for the production of bioactive polyphenols (e.g. caffeine and quinine), which have had major impacts on human society. The overall goal of this study was to develop a high-throughput workflow to identify and quantify plant polyphenols.

Methods

First, a method was optimized to extract over 40 families of phytochemicals. Then, a high-throughput metabolomic platform has been developed to identify and quantify 184 polyphenols in 15 min.

Results

The current metabolomics study of secondary metabolites was conducted on leaves from one commercial coffee variety and two wild species that also belong to the Rubiaceae family. Global profiling was performed using liquid chromatography high-resolution time-of-flight mass spectrometry. Features whose abundance was significantly different between coffee species were discriminated using statistical analysis and annotated using spectral databases. The identified features were validated by commercially available standards using our newly developed liquid chromatography tandem mass spectrometry method.

Discussion

Caffeine, trigonelline and theobromine were highly abundant in coffee leaves, as expected. Interestingly, wild Rubiaceae leaves had a higher diversity of phytochemicals in comparison to commercial coffee: defense-related molecules, such as phenylpropanoids (e.g., cinnamic acid), the terpenoid gibberellic acid, and the monolignol sinapaldehyde were found more abundantly in wild Rubiaceae leaves.
MePAL6 regulates lignin accumulation to shape cassava resistance against two-spotted spider mite
Authors: Yao Xiaowen , Liang Xiao , Chen Qing , Liu Ying , Wu Chunling , Wu Mufeng , Shui Jun , Qiao Yang , Zhang Yao , Geng Yue
Published: January 2023

Introduction

The two-spotted spider mite (TSSM) is a devastating pest of cassava production in China. Lignin is considered as an important defensive barrier against pests and diseases, several genes participate in lignin biosynthesis, however, how these genes modulate lignin accumulation in cassava and shape TSSM-resistance is largely unknown.

Methods

To fill this knowledge gap, while under TSSM infestation, the cassava lignin biosynthesis related genes were subjected to expression pattern analysis followed by family identification, and genes with significant induction were used for further function exploration.

Results

Most genes involved in lignin biosynthesis were up-regulated when the mite-resistant cassava cultivars were infested by TSSM, noticeably, the MePAL gene presented the most vigorous induction among these genes. Therefore, we paid more attention to dissect the function of MePAL gene during cassava-TSSM interaction. Gene family identification showed that there are 6 MePAL members identified in cassava genome, further phylogenetic analysis, gene duplication, cis-elements and conserved motif prediction speculated that these genes may probably contribute to biotic stress responses in cassava. The transcription profile of the 6 MePAL genes in TSSM-resistant cassava cultivar SC9 indicated a universal up-regulation pattern. To further elucidate the potential correlation between MePAL expression and TSSM-resistance, the most strongly induced gene MePAL6 were silenced using virus-induced gene silencing (VIGS) assay, we found that silencing of MePAL6 in SC9 not only simultaneously suppressed the expression of other lignin biosynthesis genes such as 4-coumarate--CoA ligase (4CL), hydroxycinnamoyltransferase (HCT) and cinnamoyl-CoA reductase (CCR), but also resulted in decrease of lignin content. Ultimately, the suppression of MePAL6 in SC9 can lead to significant deterioration of TSSM-resistance.

Discussion

This study accurately identified MePAL6 as critical genes in conferring cassava resistance to TSSM, which could be considered as promising marker gene for evaluating cassava resistance to insect pest.
Nicotiana tabacum as a dead-end trap for adult Diaphorina citri: A potential biological tactic for protecting citrus orchards
Authors: Zheng Lixia , Xu Qianqian , Gong Gu , Liao Yonglin , Yu Min , Shabala Sergey , Chen Wensheng , Wu Weijian
Published: January 2023

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), is a key vector of the causal agents of Huanglongbing (HLB), a devastating disease affecting citrus almost worldwide. Nicotiana tabacum L. is an important commercial crop in China. Field observations suggested that D. citri adults die on N. tabacum leaves when grown nearby citrus orchards. In this study, the preference for and survivorship of D. citri adults on N. tabacum and their feeding behavior were investigated. The results showed that D. citri adults were attracted to N. tabacum and to the green leaf volatiles (GLVs) (Z)-3-hexenol and (E)-2-hexenol. The survival of D. citri adults on N. tabacum was less than 30 h, which was shorter than that for adults without food (35 h) and on a suitable host Murraya exotica L. (29 days). Electrical penetration graph (EPG) recordings revealed that the pathway phase of D. citri on N. tabacum leaves consisted of four waveforms—the non-probing phase (NP), the pathway phase (PP, including intercellular probing of activity in the phloem (C) and phloem penetration (D)), phloem salivation (E1), and phloem ingestion (E2). Diaphorina citri only secreted saliva and ingested sap from phloem on N. tabacum leaves and spent the longest duration in phloem sap ingestion (E2). Moreover, L-nicotine, an important defense compound against insects in N. tabacum plants, was highly toxic to D. citri. These results suggested that N. tabacum plants could help to sustainably control the spread of D. citri and HLB when growing in and around citrus orchards.
Multiscale imaging reveals the presence of autophagic vacuoles in developing maize endosperm
Authors: Arcalís Elsa , Hörmann-Dietrich Ulrike , Stöger Eva
Published: January 2023

Cereal endosperm is solely devoted to the storage of proteins and starch that will be used by the embryo upon germination. The high degree of specialization of this tissue is reflected in its endomembrane system, in which ER derived protein bodies and protein storage vacuoles (PSVs) are of particular interest. In maize seeds, the main storage proteins are zeins, that form transport incompetent aggregates within the ER lumen and finally build protein bodies that bud from the ER. In contrast to the zeins, the maize globulins are not very abundant and the vacuolar storage compartment of maize endosperm is not fully described. Whereas in other cereals, including wheat and barley, the PSV serves as the main protein storage compartment, only small, globulin-containing PSVs have been identified in maize so far. We present here a multi-scale set of data, ranging from live-cell imaging to more sophisticated 3D electron microscopy techniques (SBF-SEM), that has allowed us to investigate in detail the vacuoles in maize endosperm cells, including a novel, autophagic vacuole that is present in early developmental stages.
Contemplation on wheat vernalization
Authors: Milec Zbyněk , Strejčková Beáta , Šafář Jan
Published: January 2023

Vernalization is a period of low non-freezing temperatures, which provides the competence to flower. This mechanism ensures that plants sown before winter develop reproductive organs in more favourable conditions during spring. Such an evolutionary mechanism has evolved in both monocot and eudicot plants. Studies in monocots, represented by temperate cereals like wheat and barley, have identified and proposed the VERNALIZATION1 (VRN1) gene as a key player in the vernalization response. VRN1 belongs to MADS-box transcription factors and is expressed in the leaves and the apical meristem, where it subsequently promotes flowering. Despite substantial research advancement in the last two decades, there are still gaps in our understanding of the vernalization mechanism. Here we summarise the present knowledge of wheat vernalization. We discuss VRN1 allelic variation, review vernalization models, talk VRN1 copy number variation and devernalization phenomenon. Finally, we suggest possible future directions of the vernalization research in wheat.
Effect of Glomus intraradices on root morphology, biomass production and phosphorous use efficiency of Chinese fir seedlings under low phosphorus stress
Authors: Tian Yunlong , Xu Jingjing , Lian Xiaoqian , Wei Bo , Ma Xiangqing , Wu Pengfei
Published: January 2023

Introduction

Available phosphorus (P) scarcity in the highly weathered soils of the subtropical forests in southern China is a serious concern. To ensure whether inoculation of arbuscular mycorrhizal fungi (AMF) with Chinese fir (Cunninghamia lanceolata) under low P stress conditions could promote its growth and P utilization capacity, an indoor pot simulation experiment was carried out with the different P supply treatments and Chinese fir seedlings as the tested material.

Methods

The experiment had two P supply treatments, no P supply (P0, 0 mmol·L-1 KH2PO4) and normal P supply (P1, 1.0 mmol·L-1 KH2PO4). The seedling in each P supply treatment was inoculated with Glomus intraradices (Gi), a widespread species of AMF in the natural environment, and with no AMF inoculation as a control treatment (CK). The Gi infection rate in the root system, root cortex tissue dissolution rate, root morphological indexes and biomass, whole plant P use efficiency, and root P use efficiency of Chinese fir were determined under different treatment conditions.

Results and Discussion

The results showed that P0 treatment significantly increased the Gi infection rate (p< 0.05). After inoculating AMF with different P supply treatments, the root cortex tissue dissolution rate was considerably enhanced. In contrast, the Chinese fir’s root length and surface area were reduced; however, the root volume did not change significantly. The average root diameter in the P0 treatment and inoculated with AMF was significantly more prominent than in the uninoculated treatment (p< 0.05). The root biomass and root-to-shoot ratio at different P supply treatments were significantly higher in the Gi infection treatment than in the CK group. Under different P supply treatments, root inoculation with Gi promoted root P use efficiency and whole plant P use efficiency. In conclusion, low P stress condition promoted the colonization of AMF in the root system, increased the dissolution of root cortex tissue, root volume, and the average diameter, and promoted root biomass accumulation and P use efficiency.
In a split second: Handwriting pauses in typical and struggling writers
Authors: Pascual Mariona , Soler Olga , Salas Naymé
Published: January 2023

Introduction

A two-second threshold has been typically used when analyzing the writing processes. However, there is only a weak empirical basis to claim that specific average numbers and durations of pauses may be associated with specific writing processes. We focused on handwriting execution pauses, because immature writers are known to struggle with transcription skills. We aimed to provide an evidence-based account of the average number and duration of handwriting pauses in the mid-Primary grades and to identify process-level markers of writing difficulties.

Methods

Eighty 3rd and 5th graders, with and without writing difficulties, participated in the study. We examined pauses in a handwriting-only task, to be able to isolate those which could only be attributed to handwriting processes. Letter features were considered, as well as children’s handwriting fluency level.

Results

The average duration of handwriting pauses was around 400ms, in line with assumptions that transcription pauses would fall under the 2,000ms threshold. We found that 3rd graders made more and longer pauses than 5th graders. Struggling writers made a similar number of pauses across grades than typically-developing children, although they were significantly longer, even after controlling for the effect of handwriting fluency.

Discussion

Our findings provide an evidence-based account of the duration of handwriting pauses. They also suggest that children need fewer and shorter handwriting pauses as they progress in automatizing transcription. However, some young writers struggle with letter formation even after 3 to 5 years of instruction.
Influence of training and selection on postural stability and its relationship with sport level in judo practitioners aged 11–14 years
Authors: Jaworski Janusz , Lech Grzegorz , Witkowski Kazimierz , Bujas Przemysław , Szczepanik Katarzyna , Piepiora Paweł
Published: January 2023

The aim of this study is to determine the influence of training and selection on postural stability and its relationship with the sports level of judo practitioners aged 11–14 years. The study group consisted of 21 children judokas, aged 11–12, and 80 of their non-training peers, as well as 19 adolescent judokas, aged 13–14, and 76 of their non-training peers. The judokas were surveyed during regional championships. The level of achievement was determined by the place taken in the tournament. The balance was assessed with the use of a CQ Stab 2P stabilographic platform (CQ Elektronik System, Poland). The device recorded the position of the foot center of pressure (COP) from 6 sensors; 3 of them being located in each platform plate. The following parameters describing the movement of the foot COP were analyzed: total path length calculated in both axes (SP); mean COP inclination (MA), size of the surface area delineated by COP (SA); mean COP frequency (MF). Significantly higher values of SP, MA, and SA were noted in non-training children (aged 11–12), while MF values were significantly higher in young judokas. The same regularity was found in the older age group. Upon comparing the means between children judokas and adolescent judokas, significant differences were noted in the case of SP and MF. In both cases, higher mean values were found in the younger judoka group. A similar comparison in the non-training group indicates statistically significant better values of all analyzed indicators in the 13–14 year-old group, except for MF. Upon examining the relationship between the values of the parameters characterizing the balance level and the sports level, both in the group of training children and adolescents, insignificant values of correlation coefficients were obtained.
The quality of life in patients with multiple sclerosis – Association with depressive symptoms and physical disability: A prospective and observational study
Authors: Kołtuniuk Aleksandra , Pawlak Beata , Krówczyńska Dorota , Chojdak-Łukasiewicz Justyna
Published: January 2023

Background

Patients with multiple sclerosis (MS) experience disabilities which significantly affect their quality of life (QOL) and mental health. Mood disorders and depressive symptoms are one of the most common psychiatric conditions in MS patients. This study aimed to evaluate the level of QOL in MS patients and to assess the influence of depressive symptoms and physical disability on QOL.

Methods

This prospective and observational study was conducted among 100 MS patients (mean age of 36.23 ± 11.77) recruited from the Lower Silesian Unit of the Polish Association for Multiple Sclerosis. This study used a questionnaire designed by the authors, which contained questions about sociodemographic and clinical data, as well as the following standardized questionnaires: the Activities of Daily Living questionnaire (ADL), the Instrumental Activities of Daily Living questionnaire (IADL), the Expanded Disability Status Scale (EDSS), the Beck Depression Inventory (BDI) and Multiple Sclerosis International Quality of Life Questionnaire (MusiQOL).

Results

The average EDSS score among patients was 3.13 ± 2.38 points. More than half of the respondents (68%) suffered from depression of varying severity. The univariate linear regression models showed that the independent (p < 0.05) QOL predictors (total MusiQOL) were as follows: the number of complaints, IADL results, BDI results, EDSS score, higher education, and material status >2000 PLN. In addition, the multiple linear regression model showed that the BDI result was a significant predictor of QOL (p < 0.005).

Conclusion

Depressive symptoms significantly affect the QOL of MS patients.
Directing memory content to attentional templates: The finiteness effect of predictive information
Authors: Chen Zhen , Li Qiankai , Li Xinyu
Published: January 2023

Visual search can be accelerated according to the properties of information stored in memory and prior knowledge of the upcoming work. This helps the searcher direct their attention to (or avoid) items that match these properties. Meanwhile, different functional areas where these properties exist become attentional templates. Compared with neutral conditions, the use of attentional templates significantly benefits reaction time (RT). However, previous studies might have confounded the memory-driven and cue-driven effects. Thus, it is less clear which factor influences the template benefits. Modeled on previous research, this study employed a new design to explore the independent effects of textual cues, thus finding an inverse effect. More specifically, positively cueing an item retained in memory did not improve behavioral performance, whereas negatively cueing an item did achieve such an enhancement. Moreover, positive cueing even resulted in some damage to attentional searching under some conditions, thus indicating that the advantages of positive cueing reported in previous studies may be driven by working memory, while the effects of negative cueing are driven by prior knowledge.
The impact of the educational marriage-matching model on the household income gap
Authors: Huo Congjia , Chen Lingming
Published: January 2023

Education has become one of the important selection criteria for homogeneous marriage. The proportion of educational homogeneous marriage in China's marriage market is increasing. The inequality of family income is closely related to the educational background of family members. The article is based on the Chinese General Social Survey (CGSS) data. It uses the Recentralized Impact Function Regression Method (RIF) to empirically test that the marriage structure under different educational backgrounds has widened the income gap in Chinese households. Propensity score matching was used to correct possible selection bias and estimate the net effect of marital education matching on household income gaps. The results showed that the increase in the proportion of educational homogeneity in marriage would expand the family income gap. Based on theory and empirical evidence, some reasonable suggestions are put forward to advocate diversified marriages, strengthen social security, and reduce the family income gap.
The Chinese automobile industry’s research and development capability and innovative performance
Authors: Liu Jili , Liu Guoxin , Cui Hainan , Chen Yuehua
Published: January 2023

The Report of China’s Automobile Industry Development 2016 points out that China’s automobile industry faces increasingly fierce competition from global peers, and domestic automobile manufacturers shall continuously improve independent innovation and industry innovative performance. Automobile manufacturers’ participation in distributed innovation and their research & development (R&D) capability play a key role in the growth of innovative performances of China’s automobile industry. With development of China’s automobile industry as the background, this study presents a theoretical framework of correlation of distributed innovation embedment, R&D capability and innovative performances of China’s automobile industry from the microscopic perspective of single industry. Several hypotheses were proposed and then verified by empirical method. Specifically, 117 effective questionnaires were collected through non-probability sampling and analyzed quantitatively, followed by hypothesis test. The results clarify the working principles of the three dimensions of distributed innovation embedment influencing innovative performances of China’s automobile industry and improvement of R&D capability of enterprises by distributed innovation. This study provides references to improvements of innovative performances of China’s automobile industry.
Personality traits, role ambiguity, and relational competence as predictors for teacher subjective wellbeing
Authors: Macovei Crenguța Mihaela , Bumbuc Ștefania , Martinescu-Bădălan Fabiana
Published: January 2023

The coronavirus pandemic has significantly reshaped the way teaching activities are carried out, thus intensifying the stress felt by teachers. The teacher-student relationship has also changed under the influence of social constraints. Together, these have affected teachers’ work efficiency and redefined their connection with the school. The present study aims to examine the extent to which personality traits, role ambiguity, and relational competence predict teacher subjective wellbeing. The study sample consisted of 105 university teachers. Three hierarchical multiple regression analyses were conducted separately for each of the three criterion variables used in this research:teaching efficacy,school connectedness,andteacher subjective wellbeing. The results indicated that the personality traitsemotionality,extraversion, andconscientiousnessare significant predictors for all three variables, whilehonesty-humility,agreeableness,andopenness to experienceare not predictors for any of the variables. However, in the third step of the regression analysis,conscientiousnesswas found to lose its predictive quality for the variablesschool connectednessandteacher subjective wellbeing, its place being taken byemotionality. Bothrole ambiguityandrelational competenceare significant predictors forteaching efficacy, forschool connectedness,and forteacher subjective wellbeing. Based on these results, universities can design some measures to reduce role ambiguity of teachers and can identify areas of training needed to increase their relational competence, while simultaneously reducing the costs associated with wellbeing and productivity problems. Several training modules and courses are proposed to be designed and included in the curriculum of initial and in-service teacher training programs, in order to contribute to increasing teachers’ performance.
The executive pay gap and stock price crash risk: Promotion or suppression?
Authors: Liu Qi , Pan Zicheng
Published: January 2023

Background

In recent years, cases of stock price crash have continued to emerge. However, yet little research to date has investigated the compensation incentives of top management team (TMT) affect the risk of stock price crash. Nor has research considered the impact of the executive pay gap on the stock price crash risk. Especially, as the “egalitarianism” was broken in the compensation system, and the increase of the degree of marketization of salaries, the executive pay gap has shown an expanding trend. Under this circumstance, we would systematically examine the association between the extent of executive pay gap and its future stock price crash risk.

Design, methodology, and approach

Based on the sample of A-Share non-financial listed companies in Shanghai and Shenzhen Stock Exchange, we used firm FE regression method to empirically examine the relationship of the internal and external compensation gaps of executives and crash risk, as well as its contigency variables and inner mechanism.

Findings

The empirical results show that there is a U-shaped relationship between the internal and external pay gap of executives and future crash risk. After passing the endogenous test and the robustness test, the conclusion still holds. Further research shows that the U-shaped relationship between the pay gap and crash risk is more pronounced, when firms are affiliated with the non-state-owned enterprise or its compensation fairness is lower. Finally, the quality of information disclosure plays a mediation effect when executive pay gap affects stock price crash risk.

Originality and value

According to the economic and behavior perspectives, we explored the impact of compensation structure on stock price crash risk from the pay gap of executives for the first time, and extended the emerging literature of forecasting future stock price crash risk and executive pay gap. In addition, a key implication of our findings is that more guidance for firms is provided to design the compensation structures and to reduce stock price crash risk.
Perception and use of social media by Indonesian adolescents and parents: A qualitative study
Authors: Purboningsih Eka Riyanti , Massar Karlijn , Hinduan Zahrotur Rusyda , Agustiani Hendriati , Ruiter Robert A. C. , Verduyn Philippe
Published: January 2023

Social media are popular among adolescents worldwide, including the global South. The way adolescents use social media is influenced by their own perception of social media but also by how their parents use and perceive social media. This study aims to understand how Indonesian young adolescents (12–15 years old) and parents of adolescents use and perceive social media. For this purpose, we conducted eight focus group discussions and eight semi-structured interviews with 30 Indonesian adolescents and 15 Indonesian parents. Thematic analysis of the qualitative data reveals that both adolescents and parents use social media for social, practical, and pleasure activities. Most adolescents mention that they consider themselves skilled in using social media, while parents consider themselves less skilled. Both adolescents and parents mention that social media offer benefits for adolescents, including emotional, social, and practical benefits. However, adolescents and parents also mention the risks of social media use for adolescents, including social, emotional, and informational risks, as well as the displacement of more meaningful activities. As such, both adolescents and parents do not perceive social media as inherently good or bad but rather as a novel medium that offers benefits for adolescents but also involves several risks to be considered by parents and other relevant stakeholders. This study adds to our understanding of social media use in the global South and offers a theoretical basis for future studies on the impact of adolescents’ social media usage on wellbeing in an Indonesian context. However, future research is necessary to depict possible differences in social media use between Indonesia and other countries in the global South.
Efficacy of school-based interventions for mental health problems in children and adolescents in low and middle-income countries: A systematic review and meta-analysis
Authors: Grande Antonio Jose , Hoffmann Mauricio Scopel , Evans-Lacko Sara , Ziebold Carolina , de Miranda Claudio Torres , Mcdaid David , Tomasi Cristiane , Ribeiro Wagner Silva
Published: January 2023

Background

Implementation of interventions to treat child and adolescent mental health problems in schools could help fill the mental health care gap in low- and middle-income countries (LMICs). Most of the evidence available come from systematic reviews on mental health prevention and promotion, and there is less evidence on treatment strategies that can be effectively delivered in schools. The aim of this review was to identify what school-based interventions have been tested to treat children and adolescents in LMICs, and how effective they are.

Methods

We conducted a systematic review including seven electronic databases. The search was carried out in October 2022. We included randomised or non-randomised studies that evaluated school-based interventions for children or adolescents aged 6–18 years living in LMICs and who had, or were at risk of developing, one or more mental health problems.

Results

We found 39 studies with 43 different pairwise comparisons, treatment for attention-deficit and hyperactivity (ADHD), anxiety, depression, and posttraumatic stress disorder (PTSD), Conduct disorder (CD). Pooled SMD were statistically significant and showed that, overall, interventions were superior to comparators for PTSD (SMD = 0.61; 95% CI = 0.37–0.86), not statistically significant for anxiety (SMD = 0.11; 95% CI = −0.13 to 0.36), ADHD (SMD = 0.36; 95% CI = −0.15 to 0.87), and for depression (SMD = 0.80; 95% CI = −0.47 to 2.07). For CD the sample size was very small, so the results are imprecise.

Conclusion

A significant effect was found if we add up all interventions compared to control, suggesting that, overall, interventions delivered in the school environment are effective in reducing mental health problems among children and adolescents.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=129376], identifier [CRD42019129376].
Electroacupuncture as a rapid-onset and safer complementary therapy for depression: A systematic review and meta-analysis
Authors: Zhang Zhinan , Cai Xiaowen , Liang Yuying , Zhang Rui , Liu Xinyu , Lu Liming , Huang Yong
Published: January 2023

Background

Electroacupuncture (EA) is a promising therapy for depression. However, a comprehensive review of EA for depression is needed.

Methods

We conducted a systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA 2020) guidelines to evaluate the efficacy and safety of EA for depression. Potentially relevant trials and reviews were searched in MEDLINE, EMBASE, PsycINFO, and CENTRAL from inception to March 2022. EA alone and combined with other therapy were eligible for inclusion. The severity of depression during and after treatment and the number of adverse events were assessed as outcomes. Risk of bias (ROB) evaluation, subgroup analysis, sensitivity analysis, reporting bias assessment, and GRADE system evaluation were also conducted.

Results

Thirty-four trials were included. The overall ROB was medium. Low-quality evidence showed that the efficacy of EA was not less than that of antidepressants [EA + selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs)] and manual acupuncture (MA). EA and EA + SSRIs had better efficacy than SSRIs alone in decreasing the severity of depression during the early treatment. Moderate-quality evidence also showed that EA and EA + SSRIs were safer than SSRIs alone. Sensitivity analysis was mostly not feasible. Major publication bias was unlikely.

Conclusion

These results indicate that the efficacy of EA is not less than that of antidepressants and MA. Moreover, EA and EA + SSRI treatments show a more rapid onset and greater safety than SSRIs. More high-quality trials are needed for further confirmation.

Systematic review registration

[www.crd.york.ac.uk/prospero/display_ record.php?RecordID=329143], identifier [CRD42022329143].
Can we better understand severe mental illness through the lens of Syndemics?
Authors: Vereeken Silke , Peckham Emily , Gilbody Simon
Published: January 2023

Current health care systems do not sufficiently address contributors, also known as modifiable behavior factors, to severe mental illnesses (SMI). Instead treatment is focused on decreasing symptom-experience rather than reducing the detrimental effect of biological predisposition and behavioral influences on illness. Health care services and patients alike call for a more comprehensive, individual approach to mental health care, especially for people with SMI. A Syndemics framework has been previously used to identify ecological and social contributors to an HIV epidemic in the 1990s, and the same framework is transferable to mental health research to identify the relationship between contributing factors and the outcomes of SMI. Using this approach, a holistic insight into mental illness experience could inform more effective health care strategies that lessen the burden of disease on people with SMI. In this review, the components of a Syndemic framework, the scientific contributions to the topic so far, and the possible future of mental health research under the implementation of a Syndemic framework approach are examined.
Optimizing COVID-19 vaccine allocation considering the target population
Authors: Wen Zongliang , Yue Tingyu , Chen Wei , Jiang Guanhua , Hu Bin
Published: January 2023

Vaccine allocation strategy for COVID-19 is an emerging and important issue that affects the efficiency and control of virus spread. In order to improve the fairness and efficiency of vaccine distribution, this paper studies the optimization of vaccine distribution under the condition of limited number of vaccines. We pay attention to the target population before distributing vaccines, including attitude toward the vaccination, priority groups for vaccination, and vaccination priority policy. Furthermore, we consider inventory and budget indexes to maximize the precise scheduling of vaccine resources. A mixed-integer programming model is developed for vaccine distribution considering the target population from the viewpoint of fairness and efficiency. Finally, a case study is provided to verify the model and provide insights for vaccine distribution.