bluuebunny/crossref_metadata_2025 huggingface dataset:
Nostalgia Promotes Parents’ Tradition Transfer to Children by Strengthening Parent-Child Relationship Closeness
Authors: Yin Yige , Jiang Tonglin , Thomaes Sander , Wildschut Tim , Sedikides Constantine
Published: August 2023

Parental tradition transfer to children is pivotal for their socialization, identity formation, and culture perpetuation. But what motivates parents to transfer traditions to their children? We hypothesized that nostalgia, an emotion strengthening interpersonal bonds, would promote tradition transfer through parent-child relationship closeness. We tested these hypotheses using cross-sectional (Studies 1 and 4), cross-lagged (Study 2 and preregistered Study 5), and experimental (Studies 3 and 6) designs. In Studies 1 to 3, nostalgia was associated with, had lagged effect on, and promoted tradition transfer. In Studies 4–6, parent-child relationship closeness mediated the link between nostalgia and tradition transfer. The findings enrich our understanding of the vertical transmission of knowledge, customs, and values, offering insight into how intergenerational bonds are reinforced and cultural heritage is maintained.
The Effects of Organizational Scandals on the Desirability of Public Organizations as Places to Work: Evidence From the VA Waitlist Scandal
Authors: Lee Shinwoo , Abner Gordon , Hameduddin Taha
Published: August 2023

Public administration scholars have extensively explored organizational scandals through two lenses: (1) inside stories of organizational scandals examining the main causes of scandals and (2) the effects of scandals on trust in government, trust in governmental officials, and public financing. Yet, we know little about how organizational scandals affect government employees’ work attitudes. Understanding how public employees react to organizational scandals deserves scholarly attention because public employees not only execute their agencies’ key functions and programs but are involved in actively addressing the organization's failures. To address this gap, we apply a quasi-experimental approach using the 2014 Department of Veterans Affairs waitlist scandal, with a specific focus on the effects of the scandal on employee job satisfaction and perceived organizational attractiveness. Empirical results using the Federal Employee Viewpoint Survey from 2011 to 2017 show that the organizational scandal had a negative effect on both outcomes.
Between Fashion and Piety: Hijab Influencers and Religious Communities in the Consumer Socialization of Indonesian Muslims
Authors: Shin Jiwon , Lew Yong Kyu , Seo Myengkyo
Published: August 2023

Fashionable hijab is a trend in Muslim societies worldwide. In Indonesia, hijab commercialization has been especially prominent. This study used consumer socialization theory to examine the relationship between hijab influencers (HIs), religious factors, attitudes toward fashionable hijab, and commodified hijab-style choices. In particular, we examined involvement with HIs, HIs' influence on hijab consumption, religiosity, and religious community involvement to investigate the mechanisms of consumer socialization. Structural equation modeling revealed that hijab influencers, as consumer socialization agents, reinforced positive attitudes toward fashionable hijab, whereas religious community involvement, as a social structural variable, had a negative effect. Finally, positive attitudes toward fashionable hijab positively influenced the pursuit of commodified hijab-style choices. These findings have practical implications for vendors targeting the Indonesian market by distinguishing commodified hijab styles from conservative hijab styles and identifying the factors influencing consumers.
Vibration related symptoms and signs in two groups of exposed workers
Authors: Gerhardsson Lars , Hagberg Mats
Published: August 2023

The aim was to compare the prevalence of vibration related symptoms and signs in two groups of vibration exposed male workers: 36 vibration exposed patients and 33 truck mechanics. All participants answered a questionnaire, passed a structured interview about work and medical history and several neurophysiological tests. The prevalence of vibration white fingers (VWF) and neurosensory symptoms was significantly higher among the exposed patients than among the truck mechanics. One neurosensory examination method identified 46% of the exposed patients with numbness and tingling, three methods up to 85%. In the total material logistic regression showed that age and increased cold sensitivity were significant predictors of both neurosensory disturbances and vibration white fingers. Muscle cramps in arms and hands, pain in hands and age were significant predictors of reduced grip strength. The differences between the two groups were more pronounced for category variables than for continuous variables.
Mutual recognition in investment fund taxation? A reflection based on recent ECJ case law
Authors: Scherleitner Moritz
Published: August 2023

Recent ECJ case law regarding the taxation of investment funds seems to include elements of mutual recognition, which is a rare phenomenon in the Court's doctrine on direct taxation. Expanding on the rather clear positions of the Court in E, Veronsaajien oikeudenvalvontayksikkö (Case C-480/19) and A SCPI (Case C-342/20), this two-part article strives towards taking a comprehensive and more systematic examination of the issue. Embedded into a broader dogmatic analysis, it will, with certain qualifiers, conclude that mutual recognition elements can be of relevance to the Court when testing national fund taxation systems under the fundamental freedoms.
Myxoid Pseudotumor Changes Affecting the Distal Ureter Associated With Urothelial Carcinoma In Situ
Authors: Ortiz-Rey José A. , García-Baizán Alejandra , Bellas-Pereira Alejandro , Barciela-Bastos Araceli , Gómez-de María Carolina , Conde-Ferreirós Marta
Published: August 2023

Myxoid pseudotumor is a pseudoneoplastic fibroblastic proliferation that has been described in the perinephric and renal sinus fat tissue. It is characterized by the presence of a myxoid matrix, intermingled with the adipocytes, and a hypocellular population of spindle-shaped and stellate cells. We report a myxoid pseudotumor involving the distal ureter, which broadens the spectrum of possible localizations of this lesion around the urinary tract. It occurred in an 80-year-old patient who underwent a nephroureterectomy indicated after an incidental radiological finding of a thickening of the distal left ureter wall which suggested a ureteral neoplasm. He had two voided urine and one ureteroscopic sample cytologies diagnosed as high-grade urothelial carcinoma, as well as a retrograde ureteroscopy ureteral biopsy which was diagnosed as urothelial carcinoma in situ. This emphasizes the problem of the possible misdiagnosis of myxoid pseudotumor as a ureteral infiltrative carcinoma due to the radiological findings being badly interpreted, compounded by the preoperative cytohistologic data on malignancy. A diffuse urothelial carcinoma in situ was seen in our specimen without infiltrative or papillary tumors. This would not support an obstructive pathogenetic mechanism as has been hypothesized for myxoid pseudotumor.
Association between sensitivity to thyroid hormone indices and osteoporosis in euthyroid patients with type 2 diabetes mellitus
Authors: Wu Xuelun , Zhai Furui , Chang Ailing , Wei Jing , Guo Yanan , Zhang Jincheng
Published: August 2023

Background:

Thyroid hormones are known to regulate bone metabolism and may influence bone mineral density (BMD), as well as the risk of osteoporosis (OP) and fractures in patients with type 2 diabetes mellitus (T2DM). Recently, sensitivity to thyroid hormone indices has been linked with T2DM and OP independently. However, the relationship between thyroid hormone sensitivity and OP in euthyroid T2DM patients has yet to be investigated.

Objectives:

The aim of this study was to determine the association between sensitivity to thyroid hormone indices and the risk of OP in euthyroid patients with T2DM.

Design:

This study employed a retrospective, cross-sectional design and utilized data acquired from the Cangzhou Central Hospital in China between 2019 and 2020.

Methods:

We retrospectively analyzed the data of 433 patients with T2DM for anthropometric measurements, clinical laboratory test results, and BMD. The thyroid-stimulating hormone index, thyrotroph thyroxine resistance index, and thyroid feedback quantile-based index (TFQI) were calculated to determine thyroid hormone sensitivity. Finally, multivariable logistic regression, generalized additive models, and subgroup analysis were performed to detect the association between sensitivity to thyroid hormone indices and the risk of OP in these patients.

Results:

We did not observe a statistically significant linear relationship between sensitivity to thyroid hormones indices and OP after covariate adjustment. However, a nonlinear relationship existed between TFQI and the prevalence of OP. The inflection point of the TFQI was at −0.29. The effect sizes (odds ratio) on the left and right of the inflection point were 0.07 [95% confidence interval (CI): 0.01–0.71; p = 0.024] and 2.78 (95% CI: 1.02–7.58; p = 0.046), respectively. This trend was consistent in older female patients with higher body mass index (BMI; 25–30 kg/m2).

Conclusion:

An approximate U-shaped relationship was observed between sensitivity to thyroid hormone indices and OP risk in euthyroid patients with T2DM with variations in sex, age, and BMI. These findings provide a new perspective to elucidate the role of thyroid hormones in OP, specifically in patients with T2DM.
Poster 117: Dancers Following Primary Hip Arthroscopy Demonstrate Favorable Outcomes and High Rate of Return to Dance at a Minimum 5-Year Follow-Up
Authors: Maldonado David , Lee Michael , Curley Andrew , Domb Benjamin
Published: August 2023

Objectives:

The purpose is to report minimum 5-year follow-up patient-reported outcome measurement scores (PROMS) and return to dance in dancers who underwent primary hip arthroscopy, and to identify predictors for secondary surgeries

Methods:

Prospectively collected data from May 2010 and June 2016 was retrospectively reviewed. Patients were included if they participated in dance one year prior to surgery at any level, had preoperative and minimum 5-year follow-up scores for the modified Harris Hip Score (mHHS), Nonarthritic Hip Score (NAHS), Hip Outcome Score–Sports Specific Subscale (HOS-SSS), and Visual Analog Scale for pain (VAS). Exclusion criteria were previous hip conditions, previous ipsilateral hip surgery, Tönnis grade > 1, or lateral center-edge angle < 18°. The minimal clinically important difference (MCID), patient acceptable symptomatic state (PASS), and the maximum outcome improvement (MOI) were reported. A logistic regression model was used to identify predictors of secondary surgeries.

Results:

Fifty-one hips (48 female dancers) were included. The average age and follow-up were 29.8 ± 17.2 years and 79.1 ± 23.2 months, respectively. Improvement in all PROMS (P < 0.001) was reported. Achievement rates of MCID for the mHHS, NAHS and VAS were 83.3%, 85.7% and 85.7%, respectively. Achievement rates of PASS for the mHHS and the International Hip Outcome Tool–12 were 90.5% and 81%, respectively. The MOI was 73.8% for the mHHS, and 78.6% for the NAHS. Six dancers (14.3%) underwent revision hip arthroscopy and three dancers (5.8%) converted to total hip arthroplasty. The rate to return to dance was 79.1%. Femoral head Outerbridge grade was identified as a predictor for secondary surgeries [P = 0.045, odds ratio 6.752, 95% CI [1.043 – 43.688]).

Conclusions:

Dancers following primary hip arthroscopy experienced significant improvement in all PROMS and achieved high rates of the MCID, PASS, and MOI at a minimum 5-year follow-up. Further, 89.3% continued to dance with 68% returning to the pre-injury or higher performance level. Femoral head Outerbridge grade was found to be a predictor for secondary surgeries.
Poster 180: A prospective randomized comparative study between isolated eccentric versus conventional exercise therapy in athletes with rotator cuff tendinopathy
Authors: Dhankhar Sarita , ROHILLA RAJESH
Published: August 2023

Objectives:

To compare the effectiveness of an isolated Eccentric exercise program versus Conventional exercise program in athletes with rotator cuff tendinopathy.

Methods:

The study included 80 athletes with rotator cuff (RC) tendinopathy (diagnosed on Magnetic resonance imaging) presenting to author’s tertiary level institute. Patients were randomized into two groups of 40 each. The eccentric exercise group (n = 40, mean age = 26.4years ) received an isolated eccentric training combined with stretching, while the conventional exercise group received scapular stabilization exercises, concentric RC strengthening exercises and stretching. (n = 40, mean age = 25.2years). Patients in both groups fulfilled 12 week daily home based exercise program and received treatments twice a week for 3 months. Primary outcome measures were shoulder pain (a 0–100mm Visual Analog Scale; VAS) and function measured with the Constant Murley score and Disabilities of the Arm, Shoulder and Hand (DASH) score. Secondary outcome measures were isometric abduction strength in 45° in the scapular plane (Hand held dynamometer) and shoulder range of motion (forward elevation, abduction and external rotation). All measurements were taken at baseline, at 12, and 24weeks. There was no statistically significant difference in pre-intervention scores between two groups. The study was approved by Institutional Review Board.

Results:

After 24 weeks, both groups showed a significant decrease in VAS scores and DASH score and a significant increase in the Constant Murley score. No statistically significant differences were found between the groups for any of the evaluated outcome measures. In the EE group, there was a slight deterioration in both CM and VAS scores between 12 and 24 weeks, but this did not reach statistical significance. Both groups also had a significant increase in isometric muscle strength between baseline and 24 weeks.

Conclusions:

A 12 week isolated eccentric training program of the rotator cuff is as effective (but not superior to) as conventional exercise program for the rotator cuff tendinopathy in athletes.
Poster 202: Subacromial Decompression is Associated with a Number Needed to Treat of 4 for Reduced Revision Rotator Cuff Repair: A Large Matched Cohort Insurance Database Analysis
Authors: Berlinberg Elyse , Derry Kendall , Patel Harsh , Forlenza Enrico , Mirle Vikranth , Gamsarian Vahram , Mascarenhas Randhir ,   Forsythe Group
Published: August 2023

Objectives:

Subacromial decompression (SAD) during arthroscopic rotator cuff repair (ARCR) has traditionally been performed to relieve impingement of the rotator cuff tendons as they pass through the subacromial space. The purpose of this study is to quantify the reduced risk of revision rotator cuff surgery conferred by performing SAD with ARCR.

Methods:

The PearlDiver administrative claims database was queried for patients who underwent ARCR between 2015-2020 with a minimum follow up of 2 years. The study population was stratified by whether concurrent SAD was performed at the time of the index ARCR. Groups were matched on age, gender, Charlson Comorbidity Index (CCI), complete versus partial tear, and comorbidities previously correlated with RCR healing. The primary outcome was requiring a revision rotator cuff repair.

Results:

The final analysis included 30,407 patients per group, with a mean age of 60 years (SD=7) and 45.3% women. Baseline demographics were similar between groups after matching. 551 (1.8%) patients without SAD vs. 437 patients with SAD (1.4%) underwent a revision rotator cuff repair, corresponding to a number needed to treat (NNT) of 3.8 (unadj-OR=0.79. 95% CI 0.70-0.90, P<0.001). In a multivariable model, factors associated with revision rotator cuff repair included subacromial decompression (adj- OR=0.79, 95%CI 0.70-0.90, P<0.001), male gender (adj-OR 0.97, 95% CI 0.97-0.98, P=0.017), older age (adj-OR=0.97, 95% CI 0.97-0.98, P<0.001), complete tear (adj-OR=3.62, 95% CI 2.87-4.57, P<0.001), tobacco use (adj-OR 1.33, 95% CI 1.12-1.52, P<0.001), and CCI (adj-OR 1.05, 95% CI 1.01-1.09, P=0.027).

Conclusions:

In a large cohort of over 60,000 patients with partial or complete rotator cuff tears, performing concurrent SAD conferred a 26% relative risk reduction (NNT»4 patients) for revision rotator cuff repair when compared to ARCR alone. These findings suggest that SAD may reduce the risk of revision rotator cuff surgery. [Table: see text][Table: see text]
Poster 224: Complications Associated with Proximal Hamstring Tendon Repair: A Systematic Review
Authors: Abraham Eliza , Imbergamo Casey , Sequeira Sean , Dreese James , Gould Heath , Lawson Jonathan
Published: August 2023

Objectives:

Proximal hamstring tendon ruptures typically occur as a result of simultaneous hip flexion and knee extension, leading to avulsion of the conjoint and/or semimembranosus tendons from their origin at the ischial tuberosity. Surgical repair of proximal hamstring tendon ruptures has been shown in multiple clinical outcome studies to be superior to nonoperative management, with improved functional scores and ability to return to sport postoperatively. Although several potential complications have been reported in the literature, few studies have comprehensively analyzed the complication profile of proximal hamstring tendon repair. The purpose of this systematic review was to identify the overall rate of complications following proximal hamstring tendon repair, to differentiate these complications into categories, and to compare the complication rates of open versus endoscopic repair.

Methods:

A systematic review of original research articles was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. To qualify for study inclusion, included articles were required to be published in English, Level 4 evidence or higher, and had to examine surgical repair of proximal hamstring tendon ruptures. No restrictions were made regarding publication date and methodological quality. Data regarding complications were extracted to calculate the overall complication rate as well as the rate of major and minor complications. A quantitative data synthesis was conducted using Chi-square tests to compare the proportion of patients who experienced complications with endoscopic and open approaches.

Results:

Forty-three articles including 2,823 proximal hamstring tendon repairs were identified. The overall postoperative complication rate was 15.4% (n = 436). The rate of major complications was 4.6%, including a 0.8% re-rupture rate, 0.8% re-operation rate, 1.7% rate of sciatic nerve injury, 0.9% rate of venous thromboembolism (VTE), and 0.4% rate of deep infection. Minor complications included posterior femoral cutaneous nerve injury (2.4%), persistent sitting pain (2.3%), persistent hamstring myopathy (2.3%), hematoma/seroma (0.8%), peri-incisional numbness (1.8%), and superficial infection (1.1%). Endoscopic proximal hamstring tendon repair was associated with a higher rate of overall complications (p = 0.012), major complications (p = 0.048), and minor complications (p < 0.001) compared to open repair.

Conclusions:

Proximal hamstring tendon repair is associated with an overall complication rate of 15.4%, including a 4.6% rate of major complications. There was a statistically significant increase in complications for patients treated endoscopically compared to those who underwent an open surgical repair.
Poster 331: ACL Graft Tear or Contralateral ACL Tear: Which is Worse???
Authors: Spindler Kurt , Jin Yuxuan ,   Group MOON Knee, Magnussen Robert
Published: August 2023

Objectives:

Anterior cruciate ligament (ACL) graft tears and contralateral ACL tears are both relatively common following primary ACL reconstruction (ACLR). While some prior studies have combined these injuries as an outcome variable (“subsequent cruciate injury”), there is little prior work comparing the outcomes of these injuries. We hypothesize that patient reported outcome measures (PROMs) and activity level are lower following revision ACLR than following contralateral ACLR.

Methods:

From a prospective cohort study of 2333 patients who underwent primary, unilateral ACLR, 298 patients were identified who underwent revision ACLR or contralateral ACLR within 5 years of primary ACLR. Following exclusion of 11 patients who had both injuries, 256 patients were eligible for study inclusion, including 124 patients who underwent revision ACLR and 132 patients who underwent contralateral ACLR. Patients were contacted for follow-up at 6 years after the primary ACL reconstruction and PROMs were collected including subjective International Knee Documentation Committee (IKDC) score, Knee Osteoarthritis pain (KOOS-Pain) and knee-related quality of life (KOOS- QOL) subscales, and Marx activity level. Patient demographic and initial injury factors, surgical factors, and PROMs were compared between groups. Multiple regression models were used to determine whether side of subsequent surgery (revision versus contralateral ACLR) was a significant predictor of outcome.

Results:

Two hundred trenty-three of 256 patients (87%) were contacted and completed PROMs at 6 years following primary ACLR. The median time from primary ACLR to second ACL surgery was lower in the revision group (1.3 years) than the contralateral group (2.0 years, p < 0.001). The revision group also demonstrated a lower incidence of partial lateral meniscectomy and was more likely to have received an allograft for the primary ACLR. There were no significant differences in age, sex, smoking status, pre- operative knee laxity, articular cartilage status at primary ACLR, medial meniscus status at primary ACLR, sport, or pre-operative PROMs between the two groups. At follow-up, the revision ACLR group demonstrated lower Marx activity level and PROMs than the contralateral injury group (Table 1). When controlling for the above factors, the revision ACL group demonstrated a 7.8 point lower IKDC (p<0.001), a 3.2 point lower KOOS-pain (p=0.012), a 10.4 point lower KOOS-QOL (p<0.001), and 2.0 point lower Marx score (p=0.002) than the contralateral ACLR group.

Conclusions:

Patients who undergo revision ACL R demonstrate with poorer PROMs and lower activity level than those who undergo subsequent revision ACLR. [Table: see text]
Poster 338: Analysis of Patient Reported Outcomes and Subsequent Surgery Rate following Quadriceps Tendon Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis in Skeletally Immature Patients: Two Year Follow-Up
Authors: Perea Sofia Hidalgo , Chipman Danielle , Cordasco Frank , Green Daniel
Published: August 2023

Objectives:

The incidence of anterior cruciate ligament reconstruction (ACLR) in pediatric and adolescent patients is increasing significantly and many patients possess risk factors that predispose to ACL re-tear. Lateral extra-articular tenodesis (LET) may be performed in conjunction with ACLR to reduce the risk of ACL re-tear. The purpose of this study is to evaluate the 2-year clinical outcomes of ACLR with soft tissue quadriceps tendon (QUAD) autograft and a lateral extra-articular tenodesis (LET) using a modified Lemaire technique in skeletally immature patients.

Methods:

A consecutive series of patients who underwent QUAD tendon autograft ACLR and LET with a minimum of 2-year follow-up data was analyzed retrospectively. ACLR techniques included all- epiphyseal (AE) and complete transphyseal (CT) and were indicated based on skeletal age. Outcome measures included participants’ return to sports (RTS), concomitant or subsequent surgical procedures and multiple patient-reported outcome measures, including Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC) and HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores.

Results:

The final cohort included 50 consecutive adolescent patients aged 11 to 16 years (mean 14.2 ± 1 years) with a minimum follow-up of 2 years. Two patients were lost to follow-up. Of the patients included in the study (n=48), 98% participated in high-risk competitive sports (Table 1). Two patients (4%) were revision ACLR. Ten (21%) patients underwent AE and 38 (79%) underwent CT ACLR. Sixteen patients (33%) had subsequent surgical procedures, including 5 contralateral ACLR, 4 meniscus surgeries, 4 QUAD autograft scar revision, 4 irrigation and debridement (2 patients, 2 each) and 3 hardware removal procedures (2 for hemi-epiphysiodesis and 1 tibial socket button removal). The rate of graft failure was 0%. At two-year follow-up, mean SANE score was 93, mean Pedi-IKDC score was 90, and mean HSS-Pedi-FABS score was 23. RTS rate was 100%.

Conclusions:

A LET when performing an ACLR is safe and should be considered as a concomitant procedure for adolescent patients that are at high risk of re-tear. [Table: see text]
Poster 347: PSYCHOLOGICAL READINESS AFTER REVISION ACL RECONSTRUCTION: A ROAR STUDY
Authors: Milewski Matthew , Coene Ryan , Cook Danielle , Kocher Mininder , Kramer Dennis , Micheli Lyle , Yen Yi-Meng , Christino Melissa , Tarchala Magdalena
Published: August 2023

Objectives:

Background: Revision ACL reconstruction (ACLR) has demonstrated worse functional outcomes and higher reinjury rates in young patients. Psychological associations with revision surgery have not previously been evaluated. Purpose: To investigate levels of psychological readiness and psychological stress in young patients after revision ACLR

Methods:

Patients, ages 10-35, were enrolled who underwent revision ACLR at one center by one of six surgeons. Psychological readiness and psychological stress was assessed 6-months post- operatively with the Anterior Cruciate Ligament Return to Sport After Injury (ACL-RSI) and PROMIS- Psychological Stress Experiences (PROMIS-PSE), respectively. The International Knee Documentation Committee (IKDC/Pedi-IKDC), and Hospital for Special Surgery Pediatric Functional Activity Scale (HSS Pedi-FABS) were also collected. Patient reported outcomes of revision ACLR patients were compared to a cohort of primary ACLR patients. Propensity score matching 3:1 was performed for age, sex, and graft type.

Results:

Matching resulted in 81 ACLR patients (57 primary and 24 revision). Mean age in the revision group was 18.6 ± 3.2 (66.7% female). The most common graft type in both the primary and revision group was BTB (65% and 67%, respectively) (Table 1). Mild negative correlation was detected between IKDC and PROMIS PSE (r=-0.31; 95% CI=-0.49, -0.10; p=0.005) and a moderate positive correlation was detected between IKDC and ACL-RSI scores (r=0.56; 95% CI=0.39, 0.70; p<0.001). Revision ACLR patients had lower psychological readiness scores (47 vs. 64, p=0.004) and lower IKDC/Pedi-IKDC scores (72 vs 78, p=0.05), compared to primary ACLR patients. Revision ACLR patients also had longer return to sports clearance compared to primary ACLR (median, 10 months vs 8 months; p=0.02). Regression analysis showed revision patients could expect a 15-point decrease in ACL RSI scores compared to patients who underwent primary ACLR surgery (95% CI=-25.30, -4.21; p=0.007). Furthermore, revision patients also could expect a 1.4 month longer return to sports clearance date compared to primary ACLR patients (95% CI=0.29, 2.60; p=0.01). No differences were noted in Pedi- FABS or PROMIS-PSE scores between revision and primary patients (Table 2).

Conclusions:

This study is the first to date to examine psychological readiness to return to sport in young patients after revision ACLR. At 6-months post-surgery, revision ACLR patients had lower psychological readiness scores, inferior knee functional outcomes scores, and delayed return to sport clearance. Greater attention to the psychological aspects of recovery in the revision ACLR setting may be important to help optimize post-operative care and outcomes. [Table: see text][Table: see text]
Compositional Shifts and Assembly in Rhizosphere-Associated Fungal Microbiota Throughout the Life Cycle of Japonica Rice Under Increased Nitrogen Fertilization
Authors: Dong Hangyu , Sun Haoyuan , Chen Conglin , Zhang Mingyu , Ma Dianrong
Published: August 2023

Soil fungal microbiomes facilitate a range of beneficial functions for their host plants, and rhizosphere fungal community composition, richness, and diversity affect plant growth and development, and crop yield. Therefore, exploring the community structure and assembly of the rhizosphere fungal microbiome and its relationship with soil biochemical properties are fundamental to elucidating how rice plants benefit from their fungal symbionts. In this study, soil samples were collected at seedling, tillering, heading, and ripening stages of rice subjected to three levels of nitrogen fertilization. Plant growth demonstrates a substantial influence on fungal community composition and diversity. From the tillering to the ripening stage, the fungal communities were governed by homogenizing dispersal and dispersal limitation. The prevalence of Glomeromycota, the beneficial fungi, was considerably higher during the heading stage compared to the three other growth stages. This increase in abundance was strongly associated with increased levels of soil nutrients and enhanced activity of nitrogen acquisition enzymes. This may be a strategy developed by rice grown in flooded soil to recruit beneficial fungi in the rhizosphere to meet high nitrogen demands. Our study findings contribute to elucidating the influence of plant development and nitrogen fertilization on the structure and composition of the fungal community as well as its relationship with soil key soil nutrient content and nitrogen-related enzyme activities. They also illustrate how a shift in the fungal community mediates and reflects the effects of nitrogen fertilization input in rice agroecosystems. These findings provide new insights into the effects of changes in nitrogen application in rice rhizosphere at different growth stages on fungal communities and soil biochemical characteristics.
Diagnosing knee osteoarthritis in patients, differences between general practitioners and orthopedic surgeons: a retrospective cohort study
Authors: Evers Bob J. , Schers Henk J. , van den Ende Cornelia H. M. , Thurlings Rogier M. , Koëter Sander
Published: August 2023

Background

knee complaints are one of the most common reasons to consult the general practitioners in the Netherlands and contribute to the increasing burden on general practitioners. A proportion of patients that are referred to orthopedic outpatient clinics are potentially referred unnecessarily. We believe osteoarthritis is not always considered by general practitioners as the cause of atraumatic knee complaints. This may impede early recognition and timely care of osteoarthritis complaints and lead to unnecessary referrals.

Methods

the aim of this study was to compare the frequency of (differential) diagnosis of osteoarthritis mentioned in referral letters of general practitioners with the frequency of osteoarthritis mentioned as orthopedic diagnosis at the outpatient clinic. Therefore we conducted a retrospective cohort study based on data collected from referral letters and the corresponding outpatient clinic reports of patients with atraumatic knee complaints of 45 years or older referred to a regional hospital in Nijmegen, The Netherlands in the period from 1-6-2019 until 1-01-2020.

Results

a total of 292 referral letters were included. In the younger aged patients (45–54 years) osteoarthritis was mentioned less frequent and meniscal lesions were mentioned more frequent in referral letters when compared to diagnoses made at the outpatient clinic. Differences in differential diagnosis of osteoarthritis as well as meniscal lesions between orthopedic surgeon and general practitioners were found (both p < 0.001, McNemar). Matching diagnoses were present in 58.2% when all referral letters were analyzed (n = 292) and 75.2% when only referrals containing a differential diagnosis were analyzed (n = 226). Matching diagnoses were present in 31.6% in the younger age categories (45–54 years). A linear trend showing fewer matching diagnoses in younger patient categories was observed (p < 0.001).

Conclusions

Osteoarthritis was less frequently mentioned in general practitioner referral letters among the differential diagnosis then it was diagnosed at the outpatient clinic, especially in younger patients (45–54 years). Also matching diagnoses in younger patients were evidently lower than in older patients, partly explained by underdiagnosing of osteoarthritis in younger patients in this cohort. Better recognition of osteoarthritis in younger patients and changing the diagnostic approach of general practitioners might improve efficacy in knee care. Future research should focus on the effectiveness of musculoskeletal triage, the need for multidisciplinary educational programs for patients and promotion of conservative treatment modalities among general practitioners.
Outpatient opioid prescribing by Alzheimer’s diagnosis among older adults with pain in United States
Authors: Huang Yinan , Aparasu Rajender R , Varisco Tyler J
Published: August 2023

Objective

To examine opioid prescribing practices for pain in older adults with and without Alzheimer’s Disease and Related Dementias (ADRD).

Methods

This cross-sectional study used National Ambulatory Medical Care Survey data (2014–2016, and 2018). Adults aged ≥ 50 years with pain were analyzed. Prescribing of opioid and concomitant sedative prescriptions (including benzodiazepines, Z-drugs, and barbiturates) were identified by the Multum lexicon code. Multivariable logistic regression evaluated the risk of opioid prescribing or co-prescribing of opioid and sedative associated with ADRD in older adults with pain.

Results

There were 13,299 office visits in older adults with pain, representing 451.75 million visits. Opioid prescribing occurred in 27.19%; 30% involved co-prescribing of opioids and sedatives. ADRD was not associated with opioid prescribing or co-prescribing of opioid and sedative therapy.

Conclusions

Opioid and sedatives are commonly prescribed in older adults with pain. Longitudinal studies need to understand the etiology and chronicity of opioid use in older patients, specifically with ADRD.
Factors influencing procalcitonin in the cerebrospinal fluid of patients after neurosurgery and its diagnostic value for intracranial infection
Authors: Wang Huajun , Zhou Chengjie , Fu Ye
Published: August 2023

Objective

This study aimed to investigate the factors influencing Procalcitonin (PCT) in the cerebrospinal fluid (CSF) of patients with high fever and suspected intracranial infection after neurosurgery and its clinical application value.

Methods

Between February 2021 and August 2022, CSF and serum samples were collected via lumbar puncture from patients with high fever and suspected intracranial infection in the Intensive Care Unit(ICU) of our hospital. Multivariate logistic regression analysis was performed to analyze the factors influencing elevated PCT in CSF. The diagnostic efficacy of each index was assessed using receiver operating characteristic (ROC) curves.

Results

A total of 183 CSF samples were collected, of which 148 had increased PCT levels, including 73 cases of intracranial infection and 75 cases in the case‒control group. Multivariate logistic regression analysis showed that intracranial infection [OR = 0.117, 95% CI: 0.025–0.559; p < 0.01] and hemorrhagic CSF [OR = 0.162, 95% CI: 0.029–0.916; p < 0.04] were factors influencing CSF PCT, while trauma [OR = 3.43, 95% CI: 0.76–15.45; p < 0.12], epileptic seizure [OR = 0.00, 95% CI: 0.00; p < 0], age [OR = 1.02, 95% CI: 0.98–1.52; p < 0.32] and Glasgow Coma Scale (GCS) score [OR = 1.03, 95% CI: 0.78–1.32; p < 0.83] did not influence CSF PCT. The CSF PCT and serum PCT levels in the intracranial infection group and the case‒control group were 0.13 (0.11, 0.25) ng/ml and 0.14 (0.07, 0.25) ng/ml and 0.14 (0.08,0.32) ng/ml and 0.23 (0.13,0.48)ng/ml, respectively, with no statistically significant difference. The median values of CSF lactate in the intracranial infection group and the case‒control group were 6.45 (4.475, 8.325) mmol/l and 3.2 (2.02, 4.200) mmol/l, respectively, with a statistically significant difference between the groups.The areas under the ROC curve of CSF PCT, serum PCT,CSF lactate, CSF PCT combined with lactate were 0.59, 0.63, 0.82,and 0.83,respectively.

Conclusion

Intracranial infection and hemorrhagic CSF are influencing factors for elevated CSF PCT following neurosurgery. It should be noted that the diagnostic value of intracranial infection by CSF PCT elevated alone is limited, but the combination it with other indicators can help improve diagnostic efficacy.
A nomogram for predicting lateral lymph node metastasis in cN0 unifocal papillary thyroid microcarcinoma
Authors: Huang Hui , Xu Siyuan , Ni Song , Wang Xiaolei , Liu Shaoyan
Published: August 2023

Background

Identifying risk factors for occult lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) can provide valuable insights into the necessity of lateral neck dissection (LND). The objective of this study was to develop a nomogram for predicting the probability of LLNM in patients with cN0 unifocal PTMC.

Methods

We conducted a retrospective analyzed a total of 4872 patients with cN0 unifocal PTMC who were treated at our center from January 2013 to June 2018. Logistic regression analysis was used to determine the risk factors for LLNM, and a nomogram was constructed based on these risk factors.

Results

The rate of LLNM was 3.2%. Tumors located in the upper lobe(odds ratio [OR] = 2.56, 95% confidence interval [CI] 1.80–3.62; p < 0.001) and size greater than 7 mm (OR = 2.59, 95% CI 1.85–3.62; p < 0.001) had a significantly higher risk of LLNM compared to tumors in the lower or middle lobe and size less than or equal to 7 mm. Tumors with extrathyroidal extension (ETE) had a significantly higher risk of LLNM (OR = 1.41, 95% CI 1.01–1.99; p = 0.044). The presence of three or more central lymph node metastases (CLNMs) (OR = 5.84, 95% CI 3.83–8.93; p < 0.001) or one or two CLNMs (OR = 2.91, 95% CI 1.93–4.42; p < 0.001) also increased the risk of LLNM compared to having no CLNMs. A nomogram incorporating these risk factors was developed, and the receiver operating characteristic (ROC) curve demonstrated an area under the curve (AUC) of 0.777, indicating a high degree of predictive accuracy.

Conclusion

Tumor location in the upper lobe, greater than 7 mm in size, ETE, and CLNMs, especially three or more, were independent risk factors for LLNM in cN0 unifocal PTMC. The nomogram based on these factors exhibited favorable predictive value and consistency.
A nomogram prediction model for the TP53mut subtype in endometrial cancer based on preoperative noninvasive parameters
Authors: Wang Wei , Li Xiaoting , Gao Yunong , Zheng Hong , Gao Min
Published: August 2023

Background

The molecular subtypes of endometrial carcinoma are significantly correlated with survival outcomes and can guide surgical methods and postoperative adjuvant therapy. Among them, the TP53mut subtype has the worst prognosis and can only be determined by detection after surgery. Therefore, identifying preoperative noninvasive clinical parameters for early prediction of the TP53mut subtype would provide important guidance in choosing the appropriate surgical method and early warning for clinicians. Our study aimed to establish a model for the early prediction of the TP53mut subtype by using preoperative noninvasive parameters of endometrial cancer and screen out potential TP53mut patients.

Methods

Information and pathological specimens of 376 patients who underwent surgery for FIGO stage I-IV endometrial cancer in the Department of Gynecology, Peking University Cancer Hospital, from June 2011 to July 2020 were collected, and 178 cases were finally included in the study as the training dataset (part A). Thirty-six cases from January 2022 to March 2023 were collected as the validation dataset (part B). Molecular subtyping was performed using a one-stop next-generation sequencing (NGS) approach. Compared with the TP53mut subtype, the POLE EDM, MSI-H and TP53 wild-type subtypes were defined as non-TP53mut subtypes. Univariate Cox regression analysis and multivariate logistic analysis were performed to determine the preoperative clinical parameters associated with the TP53mut subtype. A nomogram prediction model was established using preoperative noninvasive parameters, and its efficacy in predicting TP53mut subtype and survival outcomes was verified.

Results

The TP53mut subtype was identified in 12.4% of the part A and 13.9% of the part B. Multivariate logistic regression analysis showed that HDL-C/LDL-C level, CA125 level, and cervical or lower uterine involvement were independent influencing factors associated with the TP53mut subtype (p = 0.016, 0.047, <0.001). A TP53mut prognostic model (TPMM) was constructed based on the factors identified in the multivariate analysis, namely, TPMM = -1.385 × HDL-C/LDL-C + 1.068 × CA125 + 1.89 × CI or LUI, with an AUC = 0.768 (95% CI, 0.642 to 0.893) in the part A. The AUC of TPMM for predicting TP53mut subtype in the part B was 0.781(95% CI, 0.581 to 0.980). The progression-free survival (PFS) and overall survival (OS) of patients with the TP53mut subtype were significantly worse than those of patients with the non-TP53mut subtype, as predicted by the model in the part A.

Conclusions

TP53mut prediction model (TPMM) had good diagnostic accuracy, and survival analysis showed the model can identify patients with different prognostic risk.
The application of virtual reality exposure versus relaxation training in music performance anxiety: a randomized controlled study
Authors: Bellinger Daniel , Wehrmann Kristin , Rohde Anna , Schuppert Maria , Störk Stefan , Flohr-Jost Michael , Gall Dominik , Pauli Paul , Deckert Jürgen , Herrmann Martin J. , Erhardt-Lehmann Angelika
Published: August 2023

Background

Performance anxiety is the most frequently reported anxiety disorder among professional musicians. Typical symptoms are - on a physical level - the consequences of an increase in sympathetic tone with cardiac stress, such as acceleration of heartbeat, increase in blood pressure, increased respiratory rate and tremor up to nausea or flush reactions. These symptoms can cause emotional distress, a reduced musical and artistical performance up to an impaired functioning. While anxiety disorders are preferably treated using cognitive-behavioral therapy with exposure, this approach is rather difficult for treating music performance anxiety since the presence of a public or professional jury is required and not easily available. The use of virtual reality (VR) could therefore display an alternative. So far, no therapy studies on music performance anxiety applying virtual reality exposure therapy have investigated the therapy outcome including cardiovascular changes as outcome parameters.

Methods

This mono-center, prospective, randomized and controlled clinical trial has a pre-post design with a follow-up period of 6 months. 46 professional and semi-professional musicians will be recruited and allocated randomly to an VR exposure group or a control group receiving progressive muscle relaxation training. Both groups will be treated over 4 single sessions. Music performance anxiety will be diagnosed based on a clinical interview using ICD-10 and DSM-5 criteria for specific phobia or social anxiety. A behavioral assessment test is conducted three times (pre, post, follow-up) in VR through an audition in a concert hall. Primary outcomes are the changes in music performance anxiety measured by the German Bühnenangstfragebogen and the cardiovascular reactivity reflected by heart rate variability (HRV). Secondary outcomes are changes in blood pressure, stress parameters such as cortisol in the blood and saliva, neuropeptides, and DNA-methylation.

Discussion

The trial investigates the effect of VR exposure in musicians with performance anxiety compared to a relaxation technique on anxiety symptoms and corresponding cardiovascular parameters. We expect a reduction of anxiety but also a consecutive improvement of HRV with cardiovascular protective effects.

Trial registration

: This study was registered on clinicaltrials.gov. (ClinicalTrials.gov Number: NCT05735860)
Pharmacovigilance practice among pediatric neurologists from Poland and Germany
Authors: Kopciuch Dorota , Kus Krzysztof , Niśkiewicz Izabela , Fliciński Jędrzej , Zaprutko Tomasz , Ratajczak Piotr , Nowakowska Elżbieta , Hoffmann Karolina , Koligat-Seitz Agnieszka , Bryl Wiesław , Paczkowska Anna
Published: August 2023

Objectives

To compare the pediatric neurologists’ knowledge, practice, and barriers to the pharmacovigilance (PV) process in Poland and Germany.

Methods

The research tool was an online anonymous questionnaire on Google Forms e-mailed to pediatric neurologists from Poland and Germany.

Results

The questionnaires were handed out to 830 pediatric neurologists and 371 expressed their consent to participate in the study. Most of the neurologists were familiar with the definition of PV and adverse drug reactions (ADRs). Only 34.10% of pediatric neurologists from Poland, and 38.88% from Germany believe that many ADRs are preventable and almost most of them believe it is necessary to report ADRs from children with epilepsy. Unfortunately, in opposite to this knowledge, only 37.79% of respondents from Poland and 40.32% from Germany felt co-responsible for reporting ADRs. The main reason for the neurologists not to report ADRs was a conviction that reporting ADRs would be an additional burden generating extra work.

Conclusion

There is no big difference between the practice of PV by pediatric neurologists in Poland and Germany. System-regulated PV stabilization in the country translates into the practice of maintaining PV. Monitoring the safety of pharmacotherapy and knowledge of risks associated with ADRs should be included in the curricula of academic neurologics courses.