bluuebunny/crossref_metadata_2025 huggingface dataset:
Síndrome de Tatton-Brown-Rahman: Reporte de caso de variante en el gen DNTM3A no descrita previamente asociada al síndrome
Authors: Martin M. Fernanda , Díaz S. Catherine , Mira O. Magdalena
Published: August 2022

El Síndrome de Tatton Brown Rahman (STBR) es un síndrome de sobrecrecimiento recientemente reportado, producido por variantes en el gen DNMT3A. La descripción de su fenotipo y diferencias con sus principales diagnósticos diferenciales se encuentran aún en desarrollo, con pocos sujetos de origen latinoamericano identificados. Objetivo: Describir un caso de STBR en un individuo de población chilena para ampliar el espectro fenotípico y genotípico de este nuevo síndrome. Caso Clínico: Escolar de 9 años diagnosticado con STBR a través de secuenciación completa de exoma (WES) en quién se identificó la variante DNMT3A: c.2311C > T, p. (Arg771*) no reportada previamente en la literatura en individuos con la condición. Presentaba las principales características de este síndrome con sobrecrecimiento desde la etapa neonatal, discapacidad intelectual leve asociada a trastorno del espectro autista, ausencia de anomalías mayores en órganos internos y dismorfias características con facies tosca, cejas horizontalizadas e incisivos centrales superiores prominentes. Tuvo un electroencefalograma alterado con frecuente actividad epileptiforme interictal temporal izquierda, sin historia de convulsiones, y resonancia magnética de cerebro normal. Además, presentaba una edad ósea avanzada, hallazgo común en otros síndromes de sobrecrecimiento pero no reportado con frecuencia en el STBR. El estudio genético de su hermana resultó normal y no se pudo realizar el estudio de segregación de la variante identificada en los padres. Conclusiones: El reporte de este caso contribuye a ampliar el espectro genotípico del síndrome y a la caracterización de las manifestaciones fenotípicas incluyendo individuos de distintas etnias, recalcando sus características más comunes y otras que dificultan su diagnóstico diferencial de otros síndromes de sobrecrecimiento.
Síndrome hipotónico del recién nacido y lactante
Authors: Alarcón Benítez Daniela , Beytía Reyes María De los Angeles , Escobar Raúl G. , Nuñez Farías Alicia , López Bohner María Eugenia , Avila-Smirnow Daniela
Published: August 2022

La hipotonía del recién nacido y del lactante es un desafío diagnóstico frecuente en la práctica pediátrica. Se define como la disminución de la resistencia al movimiento pasivo. El síndrome hipotónico es un diagnóstico de trabajo y se debe identificar su causa para determinar morbilidades asociadas, pronóstico y manejo. Rápidos avances en bioinformática y pruebas genéticas moleculares permiten obtener diagnósticos de precisión tempranamente en el proceso diagnóstico, por lo cual se hace necesario realizar una revisión actualizada en este tema. El objetivo de esta actualización es describir la aproximación diagnóstica al síndrome hipotónico y sus principales etiologías. Se realizó una revisión de la literatura en PubMed y Scielo, incluyendo artículos relevantes en inglés y español publicados en los últimos 15 años. Se enfatiza el valor del examen e historia clínica en la localización de la causa de la hipotonía (central o periférica) como primer paso hacia el diagnóstico etiológico. Enfermedades sistémicas como encefalopatía hipóxico-isquémica, sepsis, insuficiencia cardíaca, alteraciones metabólicas y de electrolitos plasmáticos son aún causas comunes de hipotonía central. La hipotonía periférica implica trastornos del asta anterior de la médula espinal, nervio periférico, unión neuromuscular o músculo, de origen hereditario o adquirido. El uso de imágenes del sistema nervioso central y músculo, paneles genéticos y exoma, constituyen los más recientes aportes al diagnóstico del síndrome hipotónico. Este artículo propone un enfrentamiento inicial basado en los principales elementos clínicos que orienten a un determinado diagnóstico. La terapia es de soporte, excepto por algunas condiciones que tienen tratamiento específico.
¿Por qué estudiar sobrecarga de fluidos en niños graves? Revocación médica, heterogeneidad y resistencia al cambio.
Authors: Díaz Franco
Published: August 2022

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ТЕРМІНОЛОГІЧНИЙ АНАЛІЗ ОСНОВНИХ ДЕФІНІЦІЙ ПЕДАГОГІЧНОГО ФЕНОМЕНА «ІТ-ОСВІТА»
Authors: Єршов Микола-Олег
Published: August 2022

Актуальність дослідження зумовлена стрімкими темпами розвитку цифрових технологій і цифрового суспільства та швидким розвитком цифрової педагогіки, що потребує уточнення й конкретизації багатьох понять, які активно і не завжди доречно експлуатуються засобами масової інформації, науково-популярними й науковими джерелами.
Мета: здійснити термінологічний аналіз основних дефініцій педагогічного феномена «ІТ-освіта».
Методи: загально-теоретичні методи аналізу, синтезу та узагальнення – для вивчення документальних, оповідальних, публіцистичних і науково-популярних джерел, виявлення основних базових понять дослідження, уточнення їх семантики та особливостей введення в науковий обіг.
Результати: здійснено аналіз офіційних джерел (закони, постанови, розпорядження, накази, концепції, інформаційно-аналітичні і статистичні звіти), наукових (монографії, наукові статті, матеріали конференцій, вебінарів, семінарів), довідкових (словники, довідники, енциклопедії), навчальних (підручники, навчальні посібники), виробничо-практичних (методичні і практичні посібники, освітні програми, робочі навчальні програми, навчальні плани, звіти щодо самооцінювання освітніх програм тощо), публіцистичних і науково-популярних (публікації в ЗМІ, матеріали сайтів, вебресурсів).
Висновки: досліджено гіперо-гіпонімічні, родо-видові відношення в лексико-семантичній системі сучасної педагогічної науки, пов’язані з використанням педагогічного феномена «ІТ-освіта»; з’ясовано, що це поняття є складовою педагогічної категорії «освіта» – складного, багатоаспектного, полісемантичного явища, розмаїто представленого в офіційній, довідковій, науковій, навчальній літературі; визначено сутність поняття «ІТ-освіта», обґрунтовано лексико-семантичну групу базових і суміжних понять («цифрова освіта», «медіаосвіта», «цифрова культура», «цифрова компетентність», «ІТ-компетентність», «цифрова грамотність», «цифровізація», «діджиталізація», «цифрові навички», «digital-skills» тощо).
ВИКОРИСТАННЯ GITHUB ПРИ ВИВЧЕННІ ДИСЦИПЛІНИ «ОСНОВИ ВЕБ-ТЕХНОЛОГІЙ»
Authors: Горчинський Сергій , Горчинська Катерина
Published: August 2022

Актуальність статті зумовлена необхідністю: пошуку нових підходів до організації освітнього процесу в умовах цифровізації освіти та модернізації інформаційно-освітнього середовища закладів вищої освіти; удосконалення навчання студентів ІТ-спеціальностей дисциплінам, що пов'язані з програмуванням та вебтехнологіями; формування у здобувачів освіти навичок роботи з технологічними інструментами для розробки програмного забезпечення.
Мета: дослідити дидактичні можливості використання платформи для розміщення коду з підтримкою контроля версій та спільної роботи GitHub у процесі вивчення дисципліни «Основи веб-технологій».
Методи: теоретичні (аналіз наукових джерел, порівняння, систематизація); емпіричні (педагогічне спостереження за студентами, вивчення досвіду використання платформи GitHub в освітньому процесі).
Результати: проаналізовані функціональні особливості платформи GitHub; виявлено можливості її використання у процесі вивчення дисципліни «Основи веб-технологій» (використання повного функціоналу системи керування версіями Git при взаємодії з GitHub; безкоштовна публікація вебсайтів; зручна взаємодія студентів і викладачів при виконанні та перевірці студентських робіт; широкі можливості для виконання колективних робіт студентів; використання професійного та популярного інструменту для IT-фахівців).
Висновки: з’ясовано, що платформа GitHub має значні можливості для використання в освітньому процесі: для здачі й перевірки студентських робіт (лабораторні, індивідуальні завдання), виконання колективних проєктів (з будь-якою кількістю учасників) з програмування та вебтехнологій, розміщення навчально-методичних матеріалів для студентів.
Quantifying the Difference Between Resilience and Reliability in the Operation Planning of Mobile Resources for Power Distribution Grids
Authors: Lotfi Mohamed , Panteli Mathaios , Venkatasubramanian Balaji V. , Javadi Mohammad S. , Carvalho Leonel M. , Gouveia Clara S.
Published: August 2022

Modern power grids have high levels of distributed energy resources, automation, and inherent flexibility. Those characteristics have been proven to be favorable from an environmental, social and economic perspective. Despite the increased versatility, modern grids are becoming more vulnerable to high-impact low-probability (HILP) threats, particularly for the distribution networks. On one hand, this is due to the increasing frequency and severity of weather events and natural disasters. On the other hand, it is aggravated by the increased complexity of smart grids. Resilience is broadly defined as the capability of a system to mitigate the effects of and recover from HILP events, which is often confused with reliability that is concerned with low-impact high-probability (LIHP) ones. In this paper, a distribution system in Portugal is simulated to showcase how the utilization of flexibility and mobile energy resources (MERs) should be considered differently relative to HILP vs LIHP threats.
Analisis Penerapan Pendekatan STEM pada Pembelajaran Biologi
Authors: Syarah Mia Mai , Rahmi Yosi Laila , Darussyamsu Rahmawati
Published: August 2022

Pembelajaran biologi didalamnya memuat ilmu sains, teknologi, teknik dan matematika dari beberapa materi sehingga perlu adanya pendekatan yang akan membantu proses pembelajaran tersebut, maka salah satunya yaitu pendekatan STEM. Pendekatan STEM merupakan pendekatan yang mengintegrasikan empat disiplin ilmu, yaitu sains, teknologi, teknik dan matematika. Tujuan artikel ini untuk  menganalisis penerapan pendekatan STEM pada pembelajaran biologi. Metode yang digunakan adalah studi pustaka dengan berbagai sumber dari buku, artikel penelitian dari jurnal elektronik dan website akuntabel yang berhubungan dengan pembahasan penelitian dengan hasil yang dituliskan secara deskriptif-analisis. Hasil yang didapatkan dari studi pustaka artikel ini bahwasanya penerapan pendekatan STEM pada pembelajaran biologi dapat dihubungkan dengan berbagai model pembelajaran dan materi yang sesuai sehingga bisa memberikan pengaruh yang positif untuk meningkatkan hasil belajar siswa, keterampilan berpikir kritis siswa, literasi sains siswa, kreativitas siswa, kemampuan berpikir ilmiah tapi tidak berpengaruh untuk meningkatkan literasi teknologi dan kemampuan mengambil keputusan.
Pendayagunaan Unsur-Unsur Biologi sebagai Sumber Belajar dalam Karakteristik Teknologi Pendidikan
Authors: Thaariq Zahid Zufar At , Izza Jasmine Nurul
Published: August 2022

Teknologi pendidikan merupakan rumpun keilmuan dalam memfasilitasi belajar dan meningkatkan kinerja untuk memecahkan masalah pendidikan. Keilmuan ini secara tertulis berbicara mengenai sumber belajar sebagai upaya dalam pemecahan tersebut. Sumber belajar diklasifikasikan menjadi enam, yakni (1) pesan, (2) bahan, (3) orang/manusia, (4) alat, (5) teknik/metode, dan (6) latar/lingkungan. Unsur-unsur alami dalam biologi juga mampu didayagunakan sebagai sumber belajar yang dapat digunakan untuk pembelajaran. Mulai dari struktur, fungsi, pertumbuhan, evolusi, persebaran hingga taksonominya berperan sebagai sumber belajar yang tidak hanya terpaku dalam bidang biologi saja namun bidang lainnya juga yang saling berkaitan. Maka dari itu, penulis tertarik mengkaji kajian unsur-unsur biologi yang dapat digunakan sebagai sumber belajar dengan mengedepankan analisis karakteristik teknologi pendidikan. Karakteristiknya terdiri dari (1) pendekatan sistem, (2) pendayagunaan sumber belajar, dan (3) orientasi pada pebelajar. Harapannya dari tulisan ini dapat menjadi suatu alternatif bacaan dalam memilih serta menggunakan unsur-unsur biologi dan dikembangkan dengan landasan karakteristik teknologi pendidikan.
HUBUNGAN KOMPETENSI PEDAGOGIK GURU BIOLOGI TERHADAP MOTIVASI BELAJAR SISWA KELAS X IPA SMA MUHAMMADIYAH 2 KARANG TENGAH
Authors: Sari Tika Mayang
Published: August 2022

Abstrak

Tujuan dari penelitian ini adalah untuk mengetahui hubungan kompetensi pedagogik guru biologi terhadap motivasi belajar siswa kelas X IPA di SMA Muhammadiyah 2 Karang Tengah. Penelitian ini merupakan penelitian deskriptif kuantitatif. Populasi penelitian ini adalah seluruh siswa kelas X IPA di SMA Muhammadiyah 2 Karang Tengah. Teknik sampling yang digunakan adalah nonprobality sampling yang berupa teknik sampling jenuh karena sampel penelitian di ambil dari seluruh total populasi. Teknik pengambilan data yang digunakan yaitu kuesioner (angket) rating scale. Instrument penelitian diuji dengan uji validasi ahli (expert judgement). Hasil data penelitian kemudian akan dianalisis dengan teknik korelasi person product moment dan program SPSS. Hasil penelitian yang diperoleh menunjukan bahwa tingkat kompetensi pedagogik guru biologi dan motivasi belajar siswa kelas X berada padsda tingkat sedang. Sedangkan hasil analisis hubungan kompetensi pedagogik guru biologi dan motivasi belajar siswa kelas X IPA memiliki hubungan yang signifikan dengan nilai sig (0,000) < nilai α (0,05). Selain itu, diliat dari nilai r hubungan kedua variabel memperoleh r hitung (0,877) >r tabel (0,02201). Hasil ini menunjukan bahwa hubungan kompetensi pedagogik guru biologi terhadap motivasi belajar siswa kelas X IPA di SMA Muhammadiyah sangat kuat.

Kata Kunci: “Kompetensi Pedagogik”, “Motivasi Belajar

Abstract

The purpose of this study was to determine the relationship of the pedagogic competence of biology teachers to the learning motivation of class X science students at SMA Muhammadiyah 2 Karang Tengah. This research is a quantitative descriptive study. The population of this study were all students of class X IPA at SMA Muhammadiyah 2 Karang Tengah. The sampling technique used is non-probability sampling in the form of a saturated sampling technique because the research sample is taken from the entire total population. The data collection technique used is a rating scale questionnaire. The research instrument was tested with expert judgment test. The results of the research data will then be analyzed using the person product moment correlation technique and the SPSS program. The results of the study showed that the level of pedagogic competence of biology teachers and the learning motivation of class X students was at a moderate level. While the results of the analysis of the relationship between the pedagogic competence of biology teachers and the learning motivation of class X science students have a significant relationship with the value of sig (0.000) < value (0.05). The relationship between the two variables obtained r arithmetic (0.877) > r table (0.02201). These results indicate that the relationship between the pedagogic competence of biology teachers and the learning motivation of class X science students at SMA Muhammadiyah is very strong.

Keywords: "Pedagogic Competence; Learning Motivation ".
Inventarisasi dan Studi Komposisi Capung (Odonata) pada Area Persawahan Kelurahan Warugunung, Surabaya, Jawa Timur
Authors: Susanto Muhamad Azmi Dwi , Putri Najwa Maulidina
Published: August 2022

The rice field area of ​​Warugunung Village is an agricultural area with a pond. In rice fields there are various kinds of insects and ponds which are aquatic habitat types with great potential as natural habitats for dragonflies (Odonata). Dragonflies are flying insects that have an important role in the ecosystem, namely maintaining the balance of the food chain by being a predator for insect pests. This study aims to inventory and determine the composition of dragonflies found in the rice fields of Warugunung Village, Surabaya. The research method used is the VES (Visual Ecounter Survey) method and belt transects, as well as data analysis using the Shannon-Wienner (H') species diversity index formula. The results obtained were 17 species from 3 families with a total of 139 individuals. The results of the diversity index analysis show that the lowest diversity index is found at the Vegetation Pond observation location with a value of H'= 2.41 and the lowest diversity index is at the rice field observation location with a value of H'= 1.27.
ANALISIS MODEL PEMBELAJARAN ”KONSEP PASAR TRADISIONAL” DALAM KETERAMPILAN BERKOMUNIKASI PESERTA DIDIK
Authors: Al-Ghani Muhammad Guntur
Published: August 2022

This study aims to analyze the communication skills of students by using the "Traditional Market Concept" learning model which then results are interpreted and processed based on the perspective and conception of the researcher. This research is descriptive quantitative research, in which the results of the assessment of communication skills will be processed into a descriptive form from the researcher's point of view. This research was conducted at the Equality School Package C PKBM Serumpun Tanah Laut with 19 research subjects. This research was conducted in 2 stages, namely before using the "traditional market concept" learning model and after using the "traditional market concept" learning model. The results of the research conducted indicate that this "Traditional Market Concept" learning model can develop the communication skills of students in the Equality Package C School of PKBM Serumpun Tanah Laut. However, this research is a small study and has not included the validation, practicality and effectiveness of the “traditional market concept” learning model. So it is recommended that further research be carried out in the future that can determine the validity, practicality and effectiveness of the "traditional market concept" learning model.
The Influence of Low Temperature on the Immune System of Teleosts
Authors: Dey Manna
Published: August 2022

Due to their status as poikilothermic vertebrates, fish can experience changes in water temperature and, consequently, changes in their body temperature as a result of seasonal changes, migration, or the discharge of significant amounts of effluent into a body of water. Shifting the temperature outside of the ideal temperature range for a specific fish species might have detrimental consequences for the animal's physiology, especially its immune system. Therefore, either acute or chronic exposure to inadequate temperatures can weaken an organism's ability to protect itself against infections, putting the animal's general health at risk. Specifically, the progress gained in understanding the effects of suboptimal temperature on the soluble and cellular mediators of the innate and adaptive immune systems of fishes is the subject of this review paper. Cold stress can have a variety of impacts on different fish species, but in general, both acute and chronic suboptimal temperature exposure have suppressive effects on immunity, especially on adaptive immunity. It is vital to understand the effects of environmental temperature on fish species in order to optimize the management of wild species and to implement the best management techniques for aquaculture species.
COUNTER-TERRORISM STRATEGY OF THE PRESIDENT AND FAMILY SECURITY FORCES
Authors: Rofik Mashudi
Published: August 2022

Ancaman terorisme saat ini semakin berkembang baik berupa aksi ancaman teror maupun pelaku teroris. Begitu juga dengan ancaman teror terhadap VVIP (Very Very Important Person) Presiden Republik Indonesia dan keluarganya. Persoalan keamanan, masih ada kelalaian, kurangnya kewaspadaan, terbatasnya jumlah tim maju ke area tersebut, celah kerentanan antar ring. Paspampres Grup A perlu menyiapkan strategi khusus untuk menghadapi bentuk, ancaman, dan pelaku teror baru. Tujuan dari penelitian ini adalah untuk menganalisis strategi Kelompok A Pasukan Pengamanan Presiden dalam Mengatasi Ancaman Terorisme Terhadap Presiden dan Keluarganya. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan fenomenologis. Analisis dilakukan dengan menggunakan konsep ilmu pertahanan, konsep strategi, konsep keamanan, konsep terorisme dan konsep ancaman. Hasil penelitian menunjukkan bahwa ancaman terorisme kepada Presiden Republik Indonesia dan keluarganya secara langsung tidak pernah terjadi, namun beberapa kali telah terjadi ancaman teror terhadap instalasi kepresidenan, pengoperasian drone di kawasan istana kepresidenan, percobaan upaya menyusup ke kerumunan saat Presiden berkunjung. Paspampres Grup A terus beradaptasidengan perkembangan ancaman teror terhadap Presiden dan keluarganya dengan meningkatkan kemampuan personel, menyiapkan sarana dan prasarana, peralatan dengan teknologi canggih, dengan melakukan latihan rutin, berkoordinasi dengan aparat keamanan setempat dalam rangka optimalisasi pengamanan terhadap VVIP. Namun Paspampres Grup A masih membutuhkan tambahan personel, peralatan, perlengkapan dan sinergitas antar instansi terkait untuk menjamin keamanan, keselamatan dan kenyamanan Presiden Republik Indonesia beserta keluarganya.Kata Kunci: Paspampres Grup A, Ancaman, Terorisme, Presiden RepublikIndonesia, Strategi
STRATEGY OF THE ARMY NUBIKA ZENI COMPANY TO FACE THE COVID-19 PANDEMIC
Authors: Rizki Nur , Gumilar Nugraha , Edhie Iroth Sonny
Published: August 2022

Abstract-The threat of pandemics and epidemics of dangerous and deadly diseases is very likely to occur in Indonesia. The spread of Covid-19 that is out of control and exceeds the capacity of the epidemic, and has made the status of the spread of Covid- 19 a pandemic outbreak. Pusziad CBRNE Company is a central-level implementing agency in the field of CBRNE. Biological threats increase and spread, such as in handling the Covid-19 pandemic, Pusziad CBRNE Company has limitations. Pusziad CBRNE Company's capability is not sufficient from the aspect of the organization, personnel resources, and equipment. This study analyzes how the strategy of Pusziad CBRNE Company in dealing with the Covid-19 pandemic with qualitative research and data collection through observation, interviews, and documentation. The occurrence of the Covid-19 pandemic that hit the world, including Indonesia with a fairly high death rate, is clear evidence of a biological threat. Biological threats in Indonesia are increasing evident with the development of bio-science and its supporting facilities in Indonesia as well as the opening up of bioterrorism actions. With increasing biological threats such as the Covid-19 pandemic, the role of Pusziad CBRNE Company becomes very important. Faced with the limitations of Pusziad CBRNE Company, the strategies that need to be suggested are reviewing the Pusziad CBRNE Company organization to be upgraded to a detachment or battalion, proposing optimal budget support, equipping special equipment for CBRNE, and increasing the human capacity resources of Pusziad CBRNE Company personnel. Therefore, against the backdrop of increasing perceptions of biological threats in Indonesia, Pusziad CBRNE Company needs to improve its organization, personnel capabilities, and equipment, so that Pusziad CBRNE Company has reliable capabilities supported by a proportional organization with professional personnel and sophisticated equipment.Keywords: Nuclear biology and chemistry (CBRNE), Biological Threats, Covid-19 Pandemic, Capabilities and Strategies
NUCLEAR POWERED WARSHIP, DOES INDONESIA NEED IT?
Authors: Ningsih Tiwi Gustria
Published: August 2022

The regional security environment is heating up due to the formation of defense cooperation between Australia, America and Britain (AUKUS) with their first agreement, namely the procurement of nuclear-powered attack submarines for Australia from the US. Through the Minister of Foreign Affairs, Indonesia expressed that Indonesia is concerned about the decision because it could disrupt regional security stability and also lead to an arms race. However, this nuclear-powered submarine has many advantages that conventional diesel-powered submarines do not have. Actually, what is a nuclear-powered submarine? Which countries have used it? And does Indonesia also need submarines or other nuclear-powered warships? These three questions will be discussed in research using qualitative methods by considering previous research and international law related to maritime affairs and defense. Although Indonesia needs modernization of defense equipment to be able to balance its power with regional countries, there are many considerations if the modernization is carried out by procuring nuclear-powered submarines, ranging from costs, human resources, facilities, Indonesian principles to applicable international law .
Selective inhibition of MCL1 overcomes venetoclax resistance in a murine model of myelodysplastic syndromes
Authors: Fischer Melissa A. , Song Yuanbin , Arrate Maria P. , Gbyli Rana , Villaume Matthew T. , Smith Brianna N. , Childress Merrida A. , Stricker Thomas P. , Halene Stephanie , Savona Michael R.
Published: August 2022

Treatment for myelodysplastic syndromes (MDS) remains insufficient due to clonal heterogeneity and lack of effective clinical therapies. Dysregulation of apoptosis is observed across MDS subtypes regardless of mutations and represents an attractive therapeutic opportunity. Venetoclax (VEN), a selective inhibitor of anti-apoptotic protein B-cell lymphoma- 2 (BCL2), has yielded impressive responses in older patients with acute myeloid leukemia (AML) and high risk MDS. BCL2 family anti-apoptotic proteins BCL-XL and induced myeloid cell leukemia 1 (MCL1) are implicated in leukemia survival, and upregulation of MCL1 is seen in VEN-resistant AML and MDS. We determined in vitro sensitivity of MDS patient samples to selective inhibitors of BCL2, BCL-XL and MCL1. While VEN response positively correlated with MDS with excess blasts, all MDS subtypes responded to MCL1 inhibition. Treatment with combined VEN + MCL1 inhibtion was synergistic in all MDS subtypes without significant injury to normal hematopoiesis and reduced MDS engraftment in MISTRG6 mice, supporting the pursuit of clinical trials with combined BCL2 + MCL1 inhibition in MDS.
Creutzfeldt-Jakob disease surveillance in Australia: update to 31 December 2021
Authors: Stehmann Christiane , Senesi Matteo , Sarros Shannon , McGlade Amelia , Lewis Victoria , Simpson Marion , Klug Genevieve , McLean Catriona , Masters Colin L , Collins Steven
Published: August 2022

Abstract Nationwide surveillance of Creutzfeldt-Jakob disease (CJD) and other human prion diseases is performed by the Australian National Creutzfeldt-Jakob Disease Registry (ANCJDR). National surveillance encompasses the period since 1 January 1970, with prospective surveillance occurring from 1 October 1993. Over this prospective surveillance period, considerable developments have occurred in pre-mortem diagnostics; in the delineation of new disease subtypes; and in a heightened awareness of prion diseases in healthcare settings. Surveillance practices of the ANCJDR have evolved and adapted accordingly. This report summarises the activities of the ANCJDR during 2021. Since the ANCJDR began offering diagnostic cerebrospinal fluid (CSF) 14-3-3 protein testing in Australia in September 1997, the annual number of referrals has steadily increased. In 2021, a total of 548 domestic CSF specimens were referred for 14-3-3 protein testing; 73 persons with suspected human prion disease were formally added to the national register. As of 31 December 2021, just over half of the 73 suspect case notifications (37/73) remain classified as ‘incomplete’; 17 cases were classified as ‘definite’ and 13 as ‘probable’ prion disease; six cases were excluded through either detailed clinical follow-up (two cases) or neuropathological examination (four cases). For 2021, sixty-four percent of all suspected human-prion-disease-related deaths in Australia underwent neuropathological examination. No cases of variant or iatrogenic CJD were identified. The SARS-CoV-2 pandemic did not affect prion disease surveillance outcomes in Australia.
Outbreaks of Human Metapneumovirus in Western Sydney Aged-Care Facilities in 2018
Authors: Jones Christian G , Escarate Elizabeth , Clarke Elizabeth , Clark Penelope , Norton Sophie , Bag Shopna , Kok Jen , Dwyer Dominic , Lindley Richard I , Booy Robert
Published: August 2022

Background Human metapneumovirus (hMPV), first described in 2001, is a cause of acute respiratory tract infection in the elderly, with symptoms ranging from mild to severe, including pneumonia, but outbreaks are rarely described. Methods Between 1 July and 31 December 2018, there were three outbreaks of Influenza-like Illness (ILI) where hMPV was the primary pathogen observed, among 64 aged-care facilities (ACFs) in Western Sydney. These outbreaks were investigated by the Western Sydney Local Health District (WSLHD) Public Health Unit (PHU); multiplex polymerase chain reaction (PCR) testing was performed on nasopharyngeal swabs collected by the ACF. Results hMPV was the main causative pathogen in three outbreaks (27, 28, and 15 symptomatic cases, respectively) in late winter and early spring. Fifty-five residents and 15 staff cases (70 total cases) were identified; hMPV was detected in 12 of 63 specimens submitted. Of the cases in residents, eight were hospitalised (8/63; 15%), including five with confirmed hMPV and a further one epidemiologically linked to a positive case. Six residents died (6/63; 11%) during the hMPV outbreaks; four of these had laboratory-confirmed hMPV, with a further case epidemiologically linked to a hMPV case, with a primary diagnosis of pneumonia/viral pneumonia. The sixth death was not epidemiologically linked, nor did this case exhibit any respiratory symptoms during the outbreak; however, it was reported in line with public health guidelines. Conclusion A major challenge in 2018 was the incompleteness of testing for, and awareness of, hMPV as a viral cause of ILI by facilities, laboratories, and emergency departments, which generally opted for rapid testing for influenza and RSV only. There is no licensed vaccine or approved treatment for hMPV, so efficient infection control measures are most important.
Colocaciones de créditos de la Banca Múltiple, región Tacna, antes y después de las medidas por la emergencia sanitaria
Authors: Peñaloza Arana Eloyna Lucia , Chávez Lara Charly Evelyn , Arámbulo Ayala de Sánchez Marizol Candelaria
Published: August 2022

Teniendo en cuenta la emergencia sanitaria a nivel nacional, en marzo 2020 se dictan medidas de prevención y control por el COVID-19 en el país, y como consecuencia una paralización y/o disminución de las actividades económicas. La presente investigación tuvo como objetivo determinar el comportamiento de las colocaciones de créditos de la Banca Múltiple de la región Tacna, antes y después de las medidas por la emergencia sanitaria. La metodología tuvo un enfoque cuantitativo; tipo básico; diseño no experimental; de corte longitudinal, ya que se buscó comparar dos períodos de 20 meses cada uno. Se estableció que existen diferencias entre las colocaciones de créditos por la Banca Múltiple en la región Tacna, antes de que se implementaran las medidas restrictivas por la emergencia sanitaria, debido al COVID-19, y el período después de las medidas aplicadas. Los resultados determinaron que la media para el primer grupo, denominado “Colocación de créditos por la Banca Múltiple en la región Tacna, antes de las medidas de emergencia sanitaria”, es de 1 553 854.1380, mientras que para el otro grupo, denominado “Colocación de créditos por la Banca Múltiple en la región Tacna después de las medidas de emergencia sanitaria”, tienen una media de 1 831 637.4890; existiendo diferencias significativas en los periodos objeto de comparación de la variable en estudio. Asimismo, el crecimiento de la colocación de créditos en el primer período fue de 6 % y el segundo período tuvo una variación positiva de 23 %.
Calidad de servicio e imagen corporativa de una empresa de transporte público individual tacneña durante la COVID-19
Authors: Calderón Panigua Dennys Geovanni , Quispe Vilca Grisely Rosalie
Published: August 2022

La investigación ha considerado como objetivo principal determinar el grado de relación existente entre la calidad de servicio y la imagen corporativa que perciben los clientes de una empresa de transporte público individual tacneña durante la COVID-19, respecto a los aspectos metodológicos, es preciso indicar que tuvo un tipo de investigación básica, con un nivel correlacional, de enfoque cuantitativo y un diseño no experimental de corte transversal, asimismo empleó la técnica de la encuesta y el instrumento fue el cuestionario. De igual manera, la población estuvo constituida por 321 351 ciudadanos que viven en la provincia de Tacna, con una muestra de 382 personas y aplicación de encuesta al azar. Como resultado se ha obtenido un valor de Rho de Spearman de 0.243 con un valor de 0.000, con lo que se evidencia que existe correlación positiva baja entre las variables de investigación. Se concluye determinando que la calidad de servicio se relaciona de forma positiva significativa con la imagen corporativa que perciben los clientes de la empresa de transporte público individual tacneña, denotando que priorizar acciones de mejora vinculadas a la calidad de servicio incidirá en aumentar la imagen corporativa que los clientes tienen, específicamente aquellas vinculadas a la empatía y seguridad.
Validity and Reliability Evidence of the Functional Independence Measurement (FIM) for individuals with Neurological Disorders in Greece
Authors: Gkouma Aikaterini , Theotokatos Georgios , Geladas Nikolaos , Mandalidis Dimitrios , Skordilis Emmanouil
Published: August 2022

Background: The Functional Independence Measurement (FIM) is a valid and reliable instrument of examining the patients’ functional independence (FI) in daily activities. The FIM reliability and validity, to date has not been established by Greek clinicians. The aim of the study therefore was to provide reliability and validity evidence of the FIM in a sample of Greek patients with neurological disorders (ND). Methods: The sample was consisted from inpatients with stroke (N=50) and traumatic brain injury (N=24), who had been admitted to Greek hospitals and rehabilitation centers and healthy individuals (N=33) with corresponding demographic characteristics. Inpatients were evaluated by the lead researcher. Thirty inpatients were evaluated by two researchers to determine the inter-rater reliability. The FIM structural validity was determined by the differences between (i) inpatients and healthy individuals and (ii) inpatients of varying severity. The synchronic validity was determined with the WHODAS 2.0, the Sit-to-Stand-Test, the Time-Up-and-Go-Test and the 10Meter- Walking-Test. The FIM sensitivity of change in the patients’ clinical condition was evaluated through the differences between admission and discharge. Results: The results revealed sufficient evidence of validity (synchronic & structural), reliability (inter-rater & intra-rater) and sensitivity (admission- discharge) of the FIM in Greece. Conclusion: The FIM may be used in the future for ND inpatients assessment in Greece.
Early Type II Endoleak Complication and Open Conversion Post Endovascular Aneurysm Repair of Ruptured Abdominal Aortic Aneurysm
Authors: Li Tony Ze
Published: August 2022

Background: Endovascular Aneurysm Repair (EVAR) has been a long-stay surgical option to treat abdominal aortic aneurysms (AAA), both contained and ruptured. Endoleaks, defined as persistent flow in the aneurysm sac extrinsic to the endograft, is the most common complication. Type II endoleak (T2EL) results from collateral aortic branches (mainly lumbar arteries, inferior mesenteric artery) flowing retrogradely into the sac. It is often considered the Achilles' heel to EVAR due to the controversies in its timing of diagnosis and management. It is generally accepted that T2EL are slow growing, could expand the aneurysm sac, and carry a small but significant risk of aneurysm rupture. Case Presentation: This case reports an early post-EVAR complication due to T2EL. A 66-year-old man was brought to casualty hypotensive, minimally responsive with a rigid and tender abdomen. CT Angiography revealed a ruptured AAA contained within the retro peritoneum. The patient subsequently underwent an uncomplicated EVAR procedure. However, one-hour post procedure in ICU, he was found to be suddenly in haemorrhagic shock. Open conversion via exploratory laparotomy revealed 5L of blood within the peritoneum. Aneurysm sac was opened and four strong bleeding lumbar arteries were identified and oversewn to control the bleeding. It has hypothesised that vigorous T2EL from lumbar back-bleed, through the ruptured aneurysm sac led to ongoing bleeding into the contained retroperitoneum and subsequently secondary “rupture” into the peritoneal cavity. Conclusion: This case showed that T2EL are not all slow growing and innocuous. One should consider T2EL as a cause of a patient who is acutely deteriorating post-EVAR. Early CT-angiographic imaging post procedure may be indicated in certain groups.
Uncovering adaptive mechanisms and resilience among older adults: A qualitative study on the mental health impacts of temperature variations
Authors: Tabudlo Jerick B. , Joven Gerardo F. , Joven Marjorie F.
Published: August 2022

Background: Variable environmental temperature changes have affected different population groups; however, limited empirical studies in nursing have focused on older adults. One of the most pressing issues of today is climate change, where nurses should explore and advance their roles.
Objective: This study aimed to explore and describe the experience of older adults with temperature variations as a consequence of climate change and its impact on mental health.
Methods: Descriptive phenomenological approach was used in this study. Purposeful sampling was used in selecting key informants, while individual telephone interviews and videoconferencing platforms using a semi-structured interview guide were used as the data gathering method to gather key informants’ accounts of their experiences. Prior to data collection, authors bracket their preconceived beliefs and values regarding the phenomenon at hand. Colaizzi’s seven-step method of data analysis combined with the use of qualitative data analysis software was used to develop the themes and sub-themes.
Results: Eleven key informants aged 60-77 participated in this study. Sixty significant statements on temperature variations and mental health were extracted, while forty-one meanings were formulated from the significant statements. Important meanings were grouped into a cluster of themes which built the three major themes and seven sub-themes. The major themes are Theme 1: Active recollection and recognition of their experience; Theme 2: Symptoms of physical, social, mental, and cognitive aspects transformation; and Theme 3: Establishing adaptive mechanisms. The themes reflect a mental or cognitive process of recognizing and understanding their experiences, experiencing their impacts, developing adaptive mechanisms, and showing characteristics of resilience.  
Conclusion: The themes and sub-themes developed in this study showed that despite their vulnerability, older adults were able to implement adaptive mechanisms and showed signs of resiliency. Temperature variations brought limitations or adjustments to the physical, social, mental, and cognitive aspects of the key informants. Further studies should be conducted in other population groups and various geographical locations to identify sources of adaptive mechanisms and resilience to temperature variations and climate change among older adults. The findings should be used in developing health programs and crafting policies.
A Case Study on the Effect of Extra-curricular Activity: Focusing on English Tutoring Program at K Univ.
Authors:   The Korean Society of Culture and Convergence, Yoo Jisung , Yoon Soyoung
Published: August 2022

This study aims to explore the educational effect from convergence of regular curricula and extra-curricular activities. Since the 7th Educational Reform, overall decline in students’ academic abilities has been found. Their Weak-based learning of foreign languages caused freshmen to need more time and chances to learn English with the help of senior students. This case study is on a tutoring program, which is operated in K Univ. in Chungcheong Province. This program is one of the representative extra-curricular activities, providing various opportunities to teach and to be taught for both tutors and tutees, conducted for 8 weeks--2 hours a week. Building sound tutor-tutee relationship is of importance to have meaningful effect on improving academic achievement. To succeed in this program, more attention was paid on tutors with refresher training for establishing its system. The professor in charge gave three-time education for successful tutoring. After this program, questionnaires were given to the both two to survey their satisfaction as well as academic achievement. The result shows that this program contributes to improving self-esteem, self-efficacy, and acquiring interpersonal skills.
Prophetic power and cosmic imagination in the poetry of Choi Seung-ja: Focusing on the relationship between the translated text The House of the Spirits and Lovers, Lonely Far Away
Authors:   The Korean Society of Culture and Convergence, Kim Jeongshin
Published: August 2022

The purpose of this paper is to understand how Clara’s prophetic ability and cosmic interest in the text translated by Choi Seung-ja, Isabel Allende’s first full-length novel, The House of the Spirits(1991), appeared in Choi Seung-ja’s 5th collection Lovers(1999) and 6th collection Lonely Far Away(2010) from the perspective of receptive aesthetics. As Choi Seung-ja, not only did she read The House of the Spirits as a reader and read it again by translating it, but she used it for her poetry creation. As such, poet Choi Seung-ja showed the interaction between the receptive aesthetics as a reader and the aesthetics of influence on her own beginning. Her ‘prediction and cosmic imagination’ has expanded the realm of Korean contemporary poetry indefinitely, and this attempt of ‘new method of reading’ is the core of this article.
A Study on the Current Situation of Teaching Sixteenth-Century Four-Part Counterpoint in College Music Education of Korea
Authors:   The Korean Society of Culture and Convergence, Chi Younsim
Published: August 2022

This study was carried out to examine the current situation of teaching 16th-century fourpart counterpoint in college music education of Korea which is one of the important subjects for music major college students, by means of a questionnaire. According the outcome of the questionnaire survey, it was shown that while the four-part counterpoint lesson was satisfactorily presented for students majoring in composition, students other than composition majors did not move well forward up to the four-part counterpoint. In this study, therefore, the following methods are suggested to facilitate the lesson of four-part counterpoint; 1.
Increasing teaching hours. 2. Using a class divided into small groups so that the professor can provide immediate feedback on the outcome of individual students. 3. Carefully planning a syllabus for students to achieve their goals. 4. Causing students to access to the music literature in four or more-parts and enjoy the beauty in the art.
A Study on Contemporary Psychological Considerations of Hypnosis
Authors:   The Korean Society of Culture and Convergence, Nam Yoonjee , Park Sunghyn
Published: August 2022

In this paper, I have studied the correct understanding of hypnosis as an interventional means of treatment and healing, and on the other hand, the connection between Erickson's hypnosis and humanistic psychology in the aspect of realization of human potential. Erickson, by using the principle of hypnosis, conducted a holistic approach where the client is an existence who is interconnected with the body, community, and environment in the context of the conscious and unconscious. And Erickson utilized a transformative process, so-called, “Trance” in the process of self-expansion to find resources in the unconscious. Erickson saw the unconsciousness as a repository of human potential and creativity not a storeroom of the diseases. Erickson has a human-centered view where the problematic behavior is also each individual’s best option. Modern hypnosis is the human-centered approach acceptable to the people who have previously criticized hypnosis. In addition, hypnosis can be the important tool available to realize human potential in the point that it can help integrate the human body, mind, and soul.
Clinical evaluation of bacterial DNA using an improved droplet digital PCR for spontaneous bacterial peritonitis diagnosis
Authors: Wu Hao-Xin , Hou Wei , Zhang Wei , Wang Zheng , Guo Shan , Chen De-Xi , Li Zhen , Wei Feili , Hu Zhongjie
Published: August 2022

Objective

Bacterial DNA (bactDNA) detection can be used to quickly identify pathogenic bacteria and has been studied on ascitic fluid. We aimed to retrospectively analyze the diagnostic value and applicational prospect of the bactDNA load in spontaneous bacterial peritonitis (SBP).

Method

We extracted viable bactDNA from ascitic samples of 250 patients with decompensated cirrhosis collected from October 2019 to April 2021 and detected the bactDNA by droplet digital polymerase chain reaction (ddPCR). We used ascitic samples of a baseline cohort of 191 patients to establish diagnostic thresholds for SBP and analyze the patients’ diagnostic performance based on ascites polymorphonuclear (PMN) and clinical manifestation. We performed bactDNA quantification analysis on 13 patients with a PMN less than 250 cells/mm3 but with clinical symptoms. The dynamic changes of the bactDNA load from eight patients (before, during, and after SBP) were analyzed.

Results

After the removal of free DNA, the bactDNA detected by ddPCR was generally decreased (1.75 vs. 1.5 log copies/µl, P < 0.001). Compared with the traditional culture and PMN count in the SBP diagnosis, the bactDNA showed that the ddPCR sensitivity was 80.5%, specificity was 95.3%, positive predictive value was 82.5%, and negative predictive value was 94.7%, based on clinical composite criteria. In patients with a PMN less than 250 cells/mm3, the bactDNA load of 13 patients with symptoms was significantly higher than those without symptoms (2.7 vs. 1.7 log copies/µl, P < 0.001). The bactDNA in eight patients had SBP that decreased by 1.6 log copies/µl after 48 h of antibiotic treatment and by 1.0 log copies/µl after 3 days of continued treatment.

Conclusion

BactDNA detection can be used to further enhance the diagnostic efficiency of SBP. Therefore, the application of ddPCR assay not only can be used to discriminate and quantify bacteria but also can be used in the clinical assessment for antibiotics treatment.