bluuebunny/crossref_metadata_2025 huggingface dataset:
Adherence to the Mediterranean diet partially mediates socioeconomic differences in leukocyte LINE-1 methylation: evidence from a cross-sectional study in Italian women
Authors: Maugeri Andrea , Barchitta Martina , Magnano San Lio Roberta , Favara Giuliana , La Rosa Maria Clara , La Mastra Claudia , Basile Guido , Agodi Antonella
Published: September 2020

Although previous research demonstrated that socioeconomic status (SES) might affect DNA methylation, social inequalities alone do not completely explain this relationship. We conducted a cross-sectional study on 349 women (Catania, Italy) to investigate whether behaviors might mediate the association between SES and long interspersed nuclear elements (LINE-1) methylation, a surrogate marker of global DNA methylation. Educational level, used as an indicator of SES, and data on behaviors (i.e. diet, smoking habits, physical activity, and weight status) were collected using structured questionnaires. Adherence to Mediterranean diet (MD) was assessed by the Mediterranean Diet Score (MDS). Leukocyte LINE-1 methylation was assessed by pyrosequencing. Mediation analysis was conducted using the procedure described by Preacher and Hayes. Women with high educational level exhibited higher MDS (β = 0.669; 95%CI 0.173–1.165; p < 0.01) and LINE-1 methylation level (β = 0.033; 95%CI 0.022–0.043; p < 0.001) than their less educated counterpart. In line with this, mediation analysis demonstrated a significant indirect effect of high educational level on LINE-1 methylation through the adherence to MD (β = 0.003; 95%CI 0.001–0.006). Specifically, the mediator could account for 9.5% of the total effect. To our knowledge, this is the first study demonstrating the mediating effect of diet in the relationship between SES and DNA methylation. Although these findings should be confirmed by prospective research, they add value to the promotion of healthy dietary habits in social disadvantaged people.
Modulation of hepatitis B virus infection by epidermal growth factor secreted from liver sinusoidal endothelial cells
Authors: Chen Shin-Wei , Himeno Misao , Koui Yuta , Sugiyama Masaya , Nishitsuji Hironori , Mizokami Masashi , Shimotohno Kunitada , Miyajima Atsushi , Kido Taketomo
Published: September 2020

Hepatocytes derived from human iPSCs are useful to study hepatitis B virus (HBV) infection, however infection efficiency is rather poor. In order to improve the efficiency of HBV infection to iPSC-derived hepatocytes, we set a co-culture of hepatocytes with liver non-parenchymal cells and found that liver sinusoidal endothelial cells (LSECs) enhanced HBV infection by secreting epidermal growth factor (EGF). While EGF receptor (EGFR) is known as a co-receptor for HBV, we found that EGF enhanced HBV infection at a low dose of EGF, whereas EGF at a high dose suppressed HBV infection. EGFR is internalized by clathrin-mediated endocytosis (CME) and clathrin-independent endocytosis (CIE) pathways depending on the dose of EGF. At a high dose of EGF, the endocytosed EGFR via CIE is degraded in the lysosome. This study is the first to provide evidence that HBV is endocytosed via CME and CIE pathways at a low and high dose of EGF, respectively. In conclusion, we developed an in vitro system of HBV infection using iPSC-derived liver cells, and show that EGF secreted from LSECs modulates HBV infection in a dose dependent manner.
A clinical prediction nomogram to assess risk of colorectal cancer among patients with type 2 diabetes
Authors: Feng Lu-Huai , Su Tingting , Bu Kun-Peng , Ren Shuang , Yang Zhenhua , Deng Cheng-En , Li Bi-Xun , Wei Wei-Yuan
Published: September 2020

Colorectal cancer remains a major health burden worldwide and is closely related to type 2 diabetes. This study aimed to develop and validate a colorectal cancer risk prediction model to identify high-risk individuals with type 2 diabetes. Records of 930 patients with type 2 diabetes were reviewed and data were collected from 1 November 2013 to 31 December 2019. Clinical and demographic parameters were analyzed using univariable and multivariable logistic regression analysis. The nomogram to assess the risk of colorectal cancer was constructed and validated by bootstrap resampling. Predictors in the prediction nomogram included age, sex, other blood-glucose-lowering drugs and thiazolidinediones. The nomogram demonstrated moderate discrimination in estimating the risk of colorectal cancer, with Hosmer–Lemeshow test P = 0.837, an unadjusted C-index of 0.713 (95% CI 0.670–0.757) and a bootstrap-corrected C index of 0.708. In addition, the decision curve analysis demonstrated that the nomogram would be clinically useful. We have developed a nomogram that can predict the risk of colorectal cancer in patients with type 2 diabetes. The nomogram showed favorable calibration and discrimination values, which may help clinicians in making recommendations about colorectal cancer screening for patients with type 2 diabetes.
Nucleotide substitution rates of diatom plastid encoded protein genes are positively correlated with genome architecture
Authors: Ren Yan , Yu Mengjie , Low Wai Yee , Ruhlman Tracey A. , Hajrah Nahid H. , El Omri Abdelfatteh , Alghamdi Mohammad K. , Sabir Mumdooh J. , Alhebshi Alawiah M. , Kamli Majid R. , Sabir Jamal S. M. , Theriot Edward C. , Jansen Robert K. , Rather Irfan A.
Published: September 2020

Diatoms are the largest group of heterokont algae with more than 100,000 species. As one of the single-celled photosynthetic organisms that inhabit marine, aquatic and terrestrial ecosystems, diatoms contribute ~ 45% of global primary production. Despite their ubiquity and environmental significance, very few diatom plastid genomes (plastomes) have been sequenced and studied. This study explored patterns of nucleotide substitution rates of diatom plastids across the entire suite of plastome protein-coding genes for 40 taxa representing the major clades. The highest substitution rate was lineage-specific within the araphid 2 taxon Astrosyne radiata and radial 2 taxon Proboscia sp. Rate heterogeneity was also evident in different functional classes and individual genes. Similar to land plants, proteins genes involved in photosynthetic metabolism have lower synonymous and nonsynonymous substitutions rates than those involved in transcription and translation. Significant positive correlations were identified between substitution rates and measures of genomic rearrangements, including indels and inversions, which is a similar result to what was found in legume plants. This work advances the understanding of the molecular evolution of diatom plastomes and provides a foundation for future studies.
Cytotoxic effects of dental prosthesis grinding dust on RAW264.7 cells
Authors: Wang Wei , Li Tianshu , Luo Xue , Zhang Ke , Cao Nanjue , Liu Keda , Li Xiaoming , Zhu Yuhe
Published: September 2020

Respiratory diseases, including pulmonary fibrosis, silicosis, and allergic pneumonia, can be caused by long-term exposure to dental prosthesis grinding dust. The extent of the toxicity and pathogenicity of exposure to PMMA dust, Vitallium dust, and dentin porcelain dust differs. The dust from grinding dental prosthesis made of these three materials was characterized in terms of morphology, particle size, and elemental composition. The adverse effects of different concentrations of grinding dust (50, 150, 300, 450, and 600 μg ml−l) on RAW264.7 macrophages were evaluated, including changes in cell morphology and the production of lactate dehydrogenase (LDH) and reactive oxygen species (ROS). The dust particles released by grinding dental prosthesis made of these materials had different morphologies, particle sizes, and elemental compositions. They also induced varying degrees of cytotoxicity in RAW264.7 macrophages. A possible cytotoxicity mechanism is the induction of lipid peroxidation and plasma membrane damage as the dust particles penetrate cells. Therefore, clinicians who regularly work with these materials should wear the appropriate personal protection equipment to minimize exposure and reduce the health risks caused by these particulates.
Time-stretch infrared spectroscopy
Authors: Kawai Akira , Hashimoto Kazuki , Dougakiuchi Tatsuo , Badarla Venkata Ramaiah , Imamura Takayuki , Edamura Tadataka , Ideguchi Takuro
Published: September 2020

Improving the spectral acquisition rate of broadband mid-infrared spectroscopy promises further advancements of molecular science and technology. Unlike pump-probe spectroscopy, which requires repeated measurements with different pump-probe delays, continuous spectroscopy running at a high spectral acquisition rate enables transient measurements of fast non-repeating phenomena or statistical analysis of a large amount of spectral data. Recently, Fourier-transform infrared spectrometers with rapid delay scan mechanisms including dual-comb spectrometers have significantly improved the measurement rate up to ~1 MSpectra s−1 that is fundamentally limited by the signal-to-noise ratio. Here, we overcome the limit and demonstrate the fastest continuous broadband mid-infrared spectrometer running at 80 MSpectra s−1 by implementing a wavelength-swept time-stretch spectroscopy technique. Our proof-of-concept experiment demonstrates broadband absorption spectroscopy of phenylacetylene from 4.4 to 4.9 μm (2040–2270 cm−1) at a resolution of 15 nm (7.7 cm−1) with a signal-to-noise ratio of 85 without averaging and a shot-to-shot fluctuation of 1.3%.
Probing drug delivery and mechanisms of action in 3D spheroid cells by quantitative analysis
Authors: Heo Chae Eun , Hong Areum , Kim Minji , Lee Jong Wha , Chae Soo Yeon , Sung Ki Woong , Lee Ji Won , Heo Sung Woo , Kim Hugh I.
Published: September 2020

A mass spectrometry (MS)-based quantitative approach is presented to investigate drug delivery and mechanism of action in 3D spheroid cells.
Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain
Authors: Schirmer Lucas , Hoornaert Chloé , Le Blon Debbie , Eigel Dimitri , Neto Catia , Gumbleton Mark , Welzel Petra B. , Rosser Anne E. , Werner Carsten , Ponsaerts Peter , Newland Ben
Published: September 2020

The anti-inflammatory cytokine IL-13 can be loaded and released from heparin-based cryogel biomaterials for sustained delivery to the brain.
An efficient artificial light-harvesting system with tunable emission in water constructed from a H-bonded AIE supramolecular polymer and Nile Red
Authors: Xiao Tangxin , Wu Haoran , Sun Guangping , Diao Kai , Wei Xiaoyan , Li Zheng-Yi , Sun Xiao-Qiang , Wang Leyong
Published: September 2020

An efficient artificial light-harvesting system with tunable emission in water was successfully constructed from a H-bonded AIE supramolecular polymer and Nile Red.
A new supramolecular heterosynthon [C–I⋯OC(carboxylate)] at work: engineering copper acetate cocrystals
Authors: Torubaev Yury V. , Skabitsky Ivan V.
Published: September 2020

Carboxylate–iodine supramolecular heterosynthons in combination with energy frameworks can be reliably applied in engineering hybrid metal-carboxylate cocrystals.
On the elaboration of the next generation of thermodynamic models of solid solutions
Authors: Harvey Jean-Philippe , Gheribi Äimen E. , Rincent Antoine , Jofré Javier , Lafaye Paul
Published: September 2020

We present a new thermodynamic model to describe the energetics of solid solutions subjected to order–disorder transitions.
Atomic-scale insights into electro-steric substitutional chemistry of cerium oxide
Authors: Zhang Haiwu , Castelli Ivano E. , Santucci Simone , Sanna Simone , Pryds Nini , Esposito Vincenzo
Published: September 2020

Atomic-scale simulations identify the substitutional chemistry of cerium oxide beyond the trivalent, rare-earth cations.
An improved spectrophotometric method tests the Einstein–Smoluchowski equation: a revisit and update
Authors: Zhao Jiangbo (Tim) , Qi Cong , Li Guangrui , Schmidt Markus A.
Published: September 2020

We develop a highly accessible and accurate spectrophotometric method, and identify shortcomings of the Einstein–Smoluchowski equations in solvent scattering predictions.
A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer
Authors: Miller Jessica J. , Gaiddon Christian , Storr Tim
Published: September 2020

Small molecules targeting various aspects of the p53 protein pathway have shown significant promise in the treatment of a number of cancer types.
Novel approach to accurately predict bond strength and ligand lability in platinum-based anticancer drugs
Authors: Ponce-Vargas Miguel , Klein Johanna , Hénon Eric
Published: September 2020

We challenge the recently developed intrinsic bond strength index (IBSI) as a rapid and practical tool to assess the ligand lability in Pt(ii) complexes.
Role of aromatic vs. aliphatic amine for the variation of structural, electrical and catalytic behaviors in a series of silver phosphonate extended hybrid solids
Authors: Rom Tanmay , Paul Avijit Kumar
Published: September 2020

Four silver phosphonate frameworks have been prepared under mild hydrothermal conditions in the presence of different organic amines. The amine molecules have played crucial roles for structure building, catalytic behavior and dielectric properties.
Smart bio-gel optofluidic Mach–Zehnder interferometers multiphoton-lithographically customized with chemo-mechanical-opto transduction and bio-triggered degradation
Authors: Hou Zhi-Shan , Sun Yun-Lu , Li Qi-Song , Fan Xudong , Cheng Rong
Published: September 2020

Chemical-signal-responsive optofluidic Mach–Zehnder-interferometric optical switch customized by FsLDW.
Rapid and inexpensive microfluidic electrode integration with conductive ink
Authors: McIntyre David , Lashkaripour Ali , Densmore Douglas
Published: September 2020

Electrode integration with off-the-shelf conductive ink provides a rapid and cost-effective method to develop sophisticated microfluidic prototypes in thermoplastics.
Exploring hydrophobic diastereomeric 2,6-anhydro-glycoheptitols for their enzymatic polymerization with PEG: towards delivery applications
Authors: Khatri Vinod , Bhatia Sumati , Deep Satyanarayan , Kohli Ekta , Haag Rainer , Senapati Nihar Nalini , Prasad Ashok K.
Published: September 2020

Two sugar PEG-based amphiphilic copolymers have been synthesized by Novozym®-435-catalyzed greener solvent free transesterification reaction of diastereomeric 2,6-anhydro-glucoheptitol and 2,6-anhydro-mannoheptitol with PEG-1000 diethyl ester.
Cu(ii) complexes with tridentate sulfur and selenium ligands: catecholase and hydrolysis activity
Authors: Durigon Daniele Cocco , Maragno Peterle Marcos , Bortoluzzi Adailton João , Ribeiro Ronny Rocha , Braga Antonio Luiz , Peralta Rosely Aparecida , Neves Ademir
Published: September 2020

Two new copper(ii) mononuclear complexes (CSe and CS) were synthesized and characterized by the following techniques: X-ray crystallography, elemental analysis, IR, EPR and UV-vis spectroscopies, conductimetric analysis and mass spectrometry.
Novel poly(imide-ether)s based on xanthene and a corresponding composite reinforced with a GO grafted hyperbranched polymer: fabrication, characterization, and thermal, photophysical, antibacterial and chromium adsorption properties
Authors: Khaki Diyari , Amininasab S. Mojtaba , Namazi Hassan
Published: September 2020

High-performance polyimides (PIs) with ether linkages and trifluoromethyl (–CF3) groups based on xanthene were designed and synthesized via a polycondensation reaction of novel diamine monomers with available aromatic dianhydrides.
An HBT-based fluorescent probe for nitroreductase determination and its application in Escherichia coli cell imaging
Authors: Yang Quanzhi , Wen Yujie , Zhong Aiguo , Xu Jian , Shao Shijun
Published: September 2020

HBTPN exhibited excellent performance such as rapid response time, large Stokes shift, good selectivity and sensitivity, and long-wavelength emission.
Graphene covalently functionalized with 2,6-diaminoanthraquinone (DQ) as a high performance electrode material for supercapacitors
Authors: Yang Yuying , Ma Weixia , Zhu Hong , Meng Haixia , Wang Chengjuan , Ma Fuquan , Hu Zhongai
Published: September 2020

2,6-Diaminoaquinone molecules were covalently modified onto the surface of GO via a nucleophilic displacement reaction between the epoxy groups on the surface of GO and the –NH2 groups of DQ molecules in the presence of ammonia to form a composite material.
Metabolites of the anaerobic degradation of diethyl ether by denitrifying betaproteobacterium strain HxN1
Authors: Mitschke Nico , Jarling René , Rabus Ralf , Christoffers Jens , Wilkes Heinz
Published: September 2020

The constitutions of five metabolites formed during anaerobic degradation of diethyl ether by the denitrifying bacterium Aromatoleum sp. HxN1 were identified by comparison with synthesized standards using GC-MS.
Unusual features of nitrogen substitutions in silicene
Authors: Pham Hai Duong , Gumbs Godfrey , Su Wu-Pei , Thuy Tran Ngoc Thanh , Lin Ming-Fa
Published: September 2020

The quasiparticle properties resulting from charge and spin are clearly identified in nitrogen-substituted silicenes, for which a theoretical framework is successfully developed from first-principles calculations.
Tuning residual chirality in carbon dots with anti-microbial properties
Authors: Victoria Florence , Manioudakis John , Zaroubi Liana , Findlay Brandon , Naccache Rafik
Published: September 2020

Chiral carbon dots, prepared from the unnaturald-enantiomer of cysteine, inhibit the growth ofEscherichia coliATCC 25922 and MG1655 at a lower concentration thanl-carbon dots, prepared from thel-enantiomer.
Biophysical characterization of lutein or beta carotene-loaded cationic liposomes
Authors: Elkholy Nourhan S. , Shafaa Medhat W. , Mohammed Haitham S.
Published: September 2020

The interactions between carotenoids and membrane constituents are vital for understanding the mechanism of their dynamic action.
A novel highly selective electrochemical chlorobenzene sensor based on ternary oxide RuO2/ZnO/TiO2 nanocomposites
Authors: Alam Md. Mahmud , Mukhlish Muhammad Zobayer Bin , Tazrin Ayesha , Jui Nahida Akter , Asiri Abdullah M. , Rahman Mohammed M. , Islam Md. Akhtarul , Uddin Md. Tamez
Published: September 2020

A novel electrochemical (EC) chlorobenzene (CBZ) sensor was fabricated using a ternary oxide RuO2/ZnO/TiO2 nanocomposite (NC)-decorated glassy carbon electrode (GCE).
Physical property and gas transport studies of ultrathin polysulfone membrane from 298.15 to 328.15 K and 2 to 50 bar: atomistic molecular simulation and empirical modelling
Authors: Lock S. S. M. , Lau K. K. , Jusoh Norwahyu , Shariff A. M. , Yeong Y. F. , Yiin Chung Loong , Ammar Taqvi Syed Ali
Published: September 2020

Pioneering work to elucidate and model the effect of operating conditions on physical and transport properties of ultrathin membranes.
Correlation between microstructure and properties of graphene oxide/waterborne polyurethane composites investigated by positron annihilation spectroscopy
Authors: Han Xiaobing , Gao Jie , Chen Zhiyuan , Tang Xiuqin , Zhao Yuan , Chen Tao
Published: September 2020

Qualitative and quantitative descriptions of interfacial interactions for graphene oxide/waterborne polyurethane composites.
Ice premelting layer of ice–rubber friction studied using resonance shear measurement
Authors: Lecadre Florian , Kasuya Motohiro , Hemette Sylvain , Harano Aya , Kanno Yuji , Kurihara Kazue
Published: September 2020

Regime changes of the friction at the rubber–ice interface depending on the temperature.
Ubiquity of complex coacervation of DNA and proteins in aqueous solution
Authors: Kaushik Priyanka , Pandey Pankaj K. , Aswal V. K. , Bohidar H. B.
Published: September 2020

Complex coacervation follows the signature pathway defined by the onset of formation of interpolymer complex at rc, soluble complex at rφ, and insoluble complex at rprecip.
Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness
Authors: Moore Jeffrey M. , Thompson Tyler N. , Glaser Matthew A. , Betterton Meredith D.
Published: September 2020

Here we use simulations of driven filaments with tunable soft repulsion and rigidity in order to better understand how the interplay between filament flexibility and steric effects can lead to different active dynamic states.
Iron-based phosphides as electrocatalysts for the hydrogen evolution reaction: recent advances and future prospects
Authors: Xu Siran , Zhao Haitao , Li Tingshuai , Liang Jie , Lu Siyu , Chen Guang , Gao Shuyan , Asiri Abdullah M. , Wu Qi , Sun Xuping
Published: September 2020

This review summarizes recent advances in and future prospects of iron-based phosphides as electrocatalysts for the hydrogen evolution reaction, providing an in-depth understanding of two important aspects to boost catalytic performances.
Nanotechnology-based drug delivery systems for enhanced diagnosis and therapy of oral cancer
Authors: Ding Zhangfan , Sigdel Krishna , Yang Lei , Liu Yunfei , Xuan Ming , Wang Xiaoyi , Gu Zhipeng , Wu Jun , Xie Huixu
Published: September 2020

Oral cancer is a common malignant life-threatening tumor.
Spatiotemporal regulation of dynamic cell microenvironment signals based on an azobenzene photoswitch
Authors: Wu Kai , Sun Jing , Ma Yanzhe , Wei Dan , Lee Oscar , Luo Hongrong , Fan Hongsong
Published: September 2020

Photoisomerization and red-shifted photoswitching make azobenzene superior for exploring the cell-material interactions and designing tissue-engineering scaffolds.
Origins of the peroxidase mimicking activities of graphene oxide from first principles
Authors: Wang Di , Song Xiaolin , Li Peng , Gao Xuejiao J. , Gao Xingfa
Published: September 2020

The carbonyl groups are the active centers responsible for the peroxidase-mimicking activities of graphene oxides.
Overexpression of microRNA-205-5p exerts suppressive effects on stem cell drug resistance in gallbladder cancer by down-regulating PRKCE
Authors: Zhang Guo-Feng , Wu Jia-Cheng , Wang Hong-Yong , Jiang Wei-Dong , Qiu Ling
Published: September 2020

Some microRNAs (miRs or miRNAs) have been reported to function as tumor suppressors in gallbladder cancer (GBC). However, the specific effect of miR-205-5p on GBC remains unclear. The objective of the present study was to unravel the effects of miR-205-5p on the drug resistance in GBC. For this purpose, the expression of miR-205-5p and protein kinase C ϵ (PRKCE) was quantified in the peripheral blood sample harvested from GBC patients and healthy volunteers. Then the relationship between miR-205-5p and PRKCE was validated. After isolating the GBC stem cells, ectopic expression and depletion experiments were conducted to analyze the effect of miR-205-5p and PRKCE on cell proliferation, drug resistance, apoptosis, and colony formation rate as well as the expression of apoptotic factors (Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), and cleaved caspase 3). Finally, the mouse xenograft model of GBC was established to verify the function of miR-205-5p in vivo. Intriguingly, our results manifested that miR-205-5p was down-regulated, while PRKCE was up-regulated in peripheral blood samples and stem cells of patients with GBC. Moreover, miR-205-5p targeted PRKCE and negatively regulated its expression. The overexpression of miR-205-5p or silencing of PRKCE inhibited the drug resistance, proliferation, and colony formation rate while promoting apoptosis of GBC stem cells. Additionally, the overexpression of miR-205-5p attenuated drug resistance to gemcitabine but promoted the gemcitabine-induced cell apoptosis by inhibiting the PRKCE in vivo. Overall, an intimate correlation between miR-205-5p and PRKCE is a key determinant of drug resistance of GBC stem cells, thus, suggesting a novel miR-205-5p-based clinical intervention target for GBC patients.
Siblings or doppelgängers? Deciphering the evolution of structured cis-regulatory RNAs beyond homology
Authors: Gray Elizabeth C. , Beringer Daniel M. , Meyer Michelle M.
Published: September 2020

Structured cis-regulatory RNAs have evolved across all domains of life, highlighting the utility and plasticity of RNA as a regulatory molecule. Homologous RNA sequences and structures often have similar functions, but homology may also be deceiving. The challenges that derive from trying to assign function to structure and vice versa are not trivial. Bacterial riboswitches, viral and eukaryotic IRESes, CITEs, and 3′ UTR elements employ an array of mechanisms to exert their effects. Bioinformatic searches coupled with biochemical and functional validation have elucidated some shared and many unique ways cis-regulators are employed in mRNA transcripts. As cis-regulatory RNAs are resolved in greater detail, it is increasingly apparent that shared homology can mask the full spectrum of mRNA cis-regulator functional diversity. Furthermore, similar functions may be obscured by lack of obvious sequence similarity. Thus looking beyond homology is crucial for furthering our understanding of RNA-based regulation.
Role of the adaptive immune system in atherosclerosis
Authors: Ley Klaus
Published: September 2020

Atherosclerosis, the pathology underlying heart attacks, strokes and peripheral artery disease, is a chronic inflammatory disease of the artery wall initiated by elevated low-density lipoprotein (LDL) cholesterol levels. LDL accumulates in the artery wall, where it can become oxidized to oxLDL. T cell responses to ApoB, a core protein found in LDL and other lipoproteins, are detectable in healthy mice and people. Most of the ApoB-specific CD4T cells are FoxP3+ regulatory T cells (Treg). In the course of atherosclerosis development, the number of ApoB-reactive T cells expands. At the same time, their phenotype changes, showing cell surface markers, transcription factors and transcriptomes resembling other T-helper lineages like Th17, Th1 and follicular helper (TFH) cells. TFH cells enter germinal centers and provide T cell help to B cells, enabling antibody isotype switch from IgM to IgG and supporting affinity maturation. In people and mice with atherosclerosis, IgG and IgM antibodies to oxLDL are detectable. Higher IgM antibody titers to oxLDL are associated with less, IgG antibodies with more atherosclerosis. Thus, both T and B cells play critical roles in atherosclerosis. Modifying the adaptive immune response to ApoB holds promise for preventing atherosclerosis and reducing disease burden.
VLTI/PIONIER reveals the close environment of the evolved system HD 101584
Authors: Kluska J. , Olofsson H. , Van Winckel H. , Khouri T. , Wittkowski M. , de Wit W. J. , Humphreys E. M. L. , Lindqvist M. , Maercker M. , Ramstedt S. , Tafoya D. , Vlemmings W. H. T.
Published: September 2020

Context. The observed orbital characteristics of post-asymptotic giant branch and post-red giant branch (post-RGB) binaries are not understood. We suspect that the missing ingredients needed to explain them probably lie in the continuous interaction of the central binary with its circumstellar environment.

Aims. We aim at studying the circumbinary material in these complex systems by investigating the connection between the innermost structures and large-scale structures.

Methods. We perform high-angular resolution observations of HD 101584 in the near-infrared continuum. HD 101584 has a complex structure as seen at millimeter wavelengths, with a disk-like morphology and a bipolar outflow due to an episode of a strong binary interaction. To account for the complexity of the target, we first perform an image reconstruction and use this result to fit a geometrical model to extract the morphological and thermal features of the environment.

Results. The image reveals an unexpected double ring structure. We interpret the inner ring as having been produced by emission from dust located in the plane of the disk, and the outer ring having been produced by emission from dust that is located 1.6 [D/1kpc] au above the disk plane. The inner ring diameter (3.94 [D/1kpc] au) and temperature (T = 1540 ± 10 K) are compatible with the dust sublimation front of the disk. The origin of the out-of-plane ring (with a diameter of 7.39 [D/1kpc] au and a temperature of 1014 ± 10 K) could be episodic ejection or a dust condensation front in the outflow.

Conclusions. The observed outer ring is possibly linked with the blue-shifted side of the large-scale outflow seen by the Atacama Large Millimeter/submillimeter Array and may trace its launching location to the central star. Such observations place morphological constraints on the ejection mechanism. Additional observations are needed to constrain the origin of the out-of-plane structure.
Testing KiDS cross-correlation redshifts with simulations
Authors: van den Busch J. L. , Hildebrandt H. , Wright A. H. , Morrison C. B. , Blake C. , Joachimi B. , Erben T. , Heymans C. , Kuijken K. , Taylor E. N.
Published: September 2020

Measuring cosmic shear in wide-field imaging surveys requires accurate knowledge of the redshift distribution of all sources. The clustering-redshift technique exploits the angular cross-correlation of a target galaxy sample with unknown redshifts and a reference sample with known redshifts. It represents an attractive alternative to colour-based methods of redshift calibration. Here we test the performance of such clustering redshift measurements using mock catalogues that resemble the Kilo-Degree Survey (KiDS). These mocks are created from the MICE simulation and closely mimic the properties of the KiDS source sample and the overlapping spectroscopic reference samples. We quantify the performance of the clustering redshifts by comparing the cross-correlation results with the true redshift distributions in each of the five KiDS photometric redshift bins. Such a comparison to an informative model is necessary due to the incompleteness of the reference samples at high redshifts. Clustering mean redshifts are unbiased at |Δz|< 0.006 under these conditions. The redshift evolution of the galaxy bias of the reference and target samples represents one of the most important systematic errors when estimating clustering redshifts. It can be reliably mitigated at this level of precision using auto-correlation measurements and self-consistency relations, and will not become a dominant source of systematic error until the arrival of Stage-IV cosmic shear surveys. Using redshift distributions from a direct colour-based estimate instead of the true redshift distributions as a model for comparison with the clustering redshifts increases the biases in the mean to up to |Δz|∼0.04. This indicates that the interpretation of clustering redshifts in real-world applications will require more sophisticated (parameterised) models of the redshift distribution in the future. If such better models are available, the clustering-redshift technique promises to be a highly complementary alternative to other methods of redshift calibration.
Distance and mass of the M 104 (Sombrero) group
Authors: Karachentsev Igor D. , Makarova Lidia N. , Brent Tully R. , Anand Gagandeep S. , Rizzi Luca , Shaya Edward J.
Published: September 2020

Aims. Distances and radial velocities of galaxies in the vicinity of the luminous early-type galaxy M 104 (Sombrero) are used to derive its dark matter mass.

Methods. Two dwarf galaxies: UGCA 307 and KKSG 30 situated near M 104 were observed with the Advanced Camera for Surveys on the Hubble Space Telescope. The distances 9.03−0.51+0.84 Mpc (UGCA 307) and 9.72−0.41+0.44 Mpc (KKSG 30) were determined using the tip of the red giant branch method. These distances are consistent with the dwarf galaxies being satellites of Sombrero.

Results. Using radial velocities and projected separations of UGCA 307, KKSG 30, and a third galaxy with an accurate distance (KKSG 29), as well as 12 other assumed companions with less accurate distances, the total mass of M 104 is estimated to be (1.55 ± 0.49) × 1013 M⊙. At the K-band luminosity of the Sombrero galaxy of 2.4 × 1011 L⊙, its total mass-to-luminosity ratio is MT/LK = (65 ± 20) M⊙/L⊙, which is about three times higher than that of luminous bulgeless galaxies.
Practice and experience in achieving a high proportion of renewable energy in Germany
Authors: Yuan Wei , Wang Caixia , Ye Xiaoning , Li Qionghui , Xu Liang , Li Ziqian , Shi Zhiyong
Published: September 2020

The German federal government has set very high targets for renewable energy. In recent years, Germany’s renewable energy has developed rapidly. Germany leads the world in energy transformation, with wind and solar generating capacity accounting for nearly half. Germany’s experience and practice in developing renewable energy are worthy of our country’s reference. In this paper, the development status of renewable energy and power grid in Germany is introduced. And this paper mainly analyzes Germany’s experience and practice in achieving a high proportion of new energy access in 2019.
A short-term load forecasting taking into account the correlation of integrated energy load
Authors: Qi Xianjun , Chen Qinghui , Zheng Xiwei
Published: September 2020

This paper proposes a short-term load forecasting method that takes into account the correlation of integrated energy load. The method use wavelet packet to decompose the electric cooling and heating load in frequency bands, analyze the cross-correlation of the electric cooling and heating load in each frequency band, and choose different forecasting methods according to the strength of the correlation to reflect the cross-correlation of the load itself; the method use recurrent neural network as a forecasting model to reflect the autocorrelation of the load itself. Compared with putting the electric cooling and heating load into the same recurrent neural network or back propagation neural network for forecasting, the method in this paper considers the autocorrelation of the electric cooling and heating load itself and the cross- correlation of the electric cooling and heating load in different frequency bands. This method reduces the average absolute percentage error of the load forecasting.
Electrical performance analysis of 110 kv GIS terminal extension conducting rod
Authors: Duan Jianjia , Liu Sanwei , Zeng Zeyu , Huang Fuyong , Duan Xiaoli
Published: September 2020

As GIS terminal is in cooperation with GIS switch, the GIS terminal with 470 mm structure is usually equipped with a 757 mm structure GIS switch. In order to study the influence of the extended conductive pole on the electrical performance of GIS cable terminal, the contact resistance of the extended conductive pole is measured. The measurement results show that the contact resistance meets the requirements of conductive flow. Through finite element simulation calculation of the influence of the extended conducting rod on the GIS terminal electric field distribution, it was found that the maximum field strength of the cable terminal of the extended conducting rod increased by 2 kv/mm, which was smaller than the breakdown field strength of sulfur hexafluoride gas, and the extended conducting rod did not affect the safe and stable operation of the GIS terminal. Extend the conductive rod by finite element simulation calculation interface without air gap and 0.1 mm gap, the distribution of electric field in both cases, contact resistance conforms to the requirements under the premise, extend the conductive rod interface is 0.1 mm gap the maximum field strength of 1.4 kv/mm, less than the sulfur hexafluoride gas breakdown voltage, contact air gap does not affect the safe and stable operation of the GIS terminal.
Fault management technology of power communication room based on the Internet of Things technology
Authors: Xin Song , Chenggang Hao , Yifei Wang , Bin Guo , Xin Zhang
Published: September 2020

With the continuous development of society, the construction of smart grids has gradually begun to be valued. Smart grids can liberate more labor and enable managers to manage the grid quickly and easily. The power communication network occupies an irreplaceable position in the smart grid. However, it is inevitable that various equipment failures will occur. Therefore, it is necessary to advance the time of fault handling through fault management, then reduce the fault harmfulness. In this paper, with the support of the Internet of Things technology, a monitoring system of the power communication room is constructed based on the configuration status and application environment of equipment, and an intelligent analysis method for fault location of the power communication room based on active detection is proposed. As a result, the reliable and stable operation of the power communication room can be guaranteed by using passive management and active management.
The influence of secondary wrong wiring of voltage transformer on measurement error
Authors: Li Suya , Sun Zhao , Li Lin , Cao Meng , Wei Jufang , Zhao Cong
Published: September 2020

In this paper, the influence of mutual opposition error between the standard secondary line at the end of the test bench and the tested secondary line in the error test of voltage transformer is analyzed, and the corresponding solutions are proposed for the wrong wiring.
Business classification of Power Grid Enterprises in the development environment of Energy Internet
Authors: Li Xin , Zhang Yuan
Published: September 2020

Energy Internet is centered on electricity, based on a strong smart grid, and deeply integrates advanced information and communication technology, control technology and advanced energy technology to support the clean and low-carbon transformation of energy and electric power, comprehensive utilization efficiency optimization of energy, and the access of flexible and convenient multiple entities, which is a smart energy system with the characteristics of green safety, ubiquitous interconnection, efficient interaction, and intelligent openness. This article focuses on the impact of the development of the Energy Internet on power grid companies and the main business of power grid companies in the future development environment of the Energy Internet, providing references for the transformation and development of power grid companies.
Construction of the Framework for Exploring the Method of Air Pollution Control in Urban Planning
Authors: Tao Jiang , Lina Wei , Li Bai
Published: September 2020

In recent years, with the rapid development of the economy and the continuous advancement of the urbanization process and the continuous deepening of the degree of industrialization, the problem of air pollution is rapidly expanding in cities. Especially since 2013, a large-scale smog problem has appeared in the northern part of my country. The problem of air pollution has received widespread attention from the state and society, and has now become an important influencing factor restricting the construction of ecological civilization in my country. Therefore, through the analysis of atmospheric pollutants and the guidance of urban planning, we can fully optimize and distribute the industrial structure and deal with atmospheric problems from the source.
Carbon Footprint of Household Consumption of Different Income
Groups —— Evidence from Micro-data of Chinese Households
Authors: Lai Siyue , Wang Xinyue , Li Yuchen
Published: September 2020

It is significant to discuss the carbon emissions in household consumption to achieve the goal of
energy conservation and emission reduction. Based on the CLA analysis method, this paper calculates the
carbon emissions of Chinese households in 2015 from a micro perspective, and analyzes the characteristics
and structure of household carbon emissions at different income levels in different regions. The results show
that most household carbon emissions come from direct energy, food, medical and daily necessities
consumption, and the proportion of these three factors in household total carbon emissions gradually
decreases with the increase of income level. At the regional level, the increase in income level does not
necessarily lead to an increase in carbon emissions. Household carbon emissions and carbon emission
structure fluctuate with income in a certain trend.
Analysis of NQI technology integration and application status of building sanitary ceramics industry
Authors: Yibing Tan
Published: September 2020

Based on the National Quality (National Quality Infrastructure, NQI) theoretical connotation as the instruction, this paper analyzes the domestic building sanitary ceramics industry key generic NQI technology integration and application of the status quo, the results show that the current domestic building sanitary ceramics industry NQI key generic technology integration and application level is not high, it is difficult to meet the demand of industry transformation and upgrading of the green, in urgent need of research to support green building sanitary ceramics industry upgrade of key generic NQI technology,to form a scientific and rational green building sanitary ceramics key testing equipment measuring standard, high quality green building sanitary ceramics standards, certification evaluation standard, and green standards in key areas (energy saving, water saving, low carbon), implementation contains measuring, testing, standards, certification and accreditation whole chain NQI technology system and carry out application demonstration, to accelerate the transformation and upgrading of domestic green building sanitary ceramics industry form the standard support and high quality development.
Research on new urbanization in Shaanxi Province under the Rural Revitalization Strategy：Take Hanzhong city as a case
Authors: Dong Hao , Ru Qian , Fu Quan , Li Zongwu , Zhang Yi , Jiang Chao , Wu Tao , Li Jiaze
Published: September 2020

The implementation of the rural revitalization strategy can not only talk about the rural areas, but also combine with the new urbanization to drive the transfer of rural population to cities and towns. Taking Hanzhong city as the research area, taking industrial prosperity and ecological livability as the core, and based on the assessment of Rural Development Problems, the paper makes clear the theoretical logic and key tasks of rural revitalization in Hanzhong city. On the basis of evaluating the index system of Agricultural Ecology and urbanization in Hanzhong city, this paper studies the degree of coupling coordinated development by using the coupled coordinated development degree model. It can be used for reference in the construction of new urbanization in other similar areas of Shaanxi Province.
Research on diabetes prediction method based on electronic medical record data analysis
Authors: Hui Chen , Mingyuan Wang , Dingjun Tang , Longwei Zhang , Ziyan Guo , Jun Zhao
Published: September 2020

The continuous progress of computer science and technology has accelerated the pace of informatization construction of the medical system. Medical technology has developed rapidly in various research directions, and the construction of medical IT systems has been continuously improved. The popular application of electronic medical records has produced massive medical data in the medical process. At the same time, in medical behavior, more and more rely on data to make relevant judgments. The coverage of medical equipment is becoming more and more extensive, and the accuracy of data is constantly improving, and the clinical diagnosis is gradually shifting from qualitative judgment to quantitative analysis. Based on the analysis of electronic medical record data, this article studies and analyzes the risk factors leading to diabetes. By analyzing the characteristic variables, the risk factors significantly related to diabetes are obtained as the input variables of the BP neural network model. For complex problems, machine learning algorithms have higher accuracy and stronger generalization capabilities. Based on the BP artificial neural network model, this paper builds and builds a machine learning simulation to predict diabetes.
A Score Level Fusion Method on Fingerprint and Finger Vein
Authors: Peng Jian , Wu Jingyi , Chen Yun
Published: September 2020

In this paper, we represent a score level fusion method on fingerprint and finger vein. Each unimodal identification system carries out processes of image preprocessing, feature extraction and feature matching to generate a vector of score. And we apply clustering analysis to split the score range into zones of interest. Then a decision tree and weighted-sum approach are used to make the decision. We test the proposed method on standard biometric database. Three metrics, namely, False Accept Rate, False Reject Rate, Recognition Rate, are used to evaluate experimental results. And experimental results show that the fusion system has a better performance than unimodal identification system.
Research Status and Development Trend of Chinese Medicine Chewing Gum
Authors: Yan Ni , Wen Ya , Tu Xi-Mei
Published: September 2020

At present, chewing gum plays a certain role in the medical field. With the increasing demand for health care functional products, Chinese Medicine Chewing Gum is gradually developing. In this paper, the function, formulation and preparation technology of Chinese medicine chewing gum are summarized and analyzed in detail based on literature and patent, expecting that the chewing gum will be given more value and meaning in the future.
Research Progress in the Functional Textiles
Authors: Zhou Wei , Zhou Zhaoyi , Zhou Peng
Published: September 2020

This paper reviews the latest research progress of functional textiles at home and abroad. List some of the latest research results and briefly introduce their products.
Combining bioinformatic prediction and assay experiment to identify novel xanthine oxidase inhibitory peptides from Pacific bluefin tuna (Thunnus Orientalis)
Authors: Bu Ying , Wang Fei , Zhu Wenhui , Li Xuepeng
Published: September 2020

In this work, we aim to combine bioinformatic prediction with a special experiment to search xanthine oxidase (XOD) inhibitory peptides from myosin of Pacific bluefin tuna (Thunnus Orientalis). The program Peptide Cutter, Peptide Ranker, Peptide Property calculator, Toxin Pred, and Discovery Studio (DS) help us screen the probable sequence. The result indicated that peptide ICRK has the highest inhibition effect and the value of IC50 was 14.18 mg/mL. The IC50 of the other two peptides (FDAK and MMER) were 16.8mg/mL and 15.3 mg/mL respectively. Molecular simulation demonstrated that ICRK interacted with amino acid residues GLU802, PHE914, ALA1079, GLU1261, LYS771, LEU648, THR1010, VAL1011 and SER 876. The possible inhibition mechanism of peptides and enzyme was stated by DS. Peptide ICRK blocked the entrance to the hydrophobic channel and stopped xanthine going into the active site of XOD. MMER and FDAK have the similar mechanism with ICRK. Therefore, ICRK, FDAK and MMER can be considered as nature XOD inhibitory peptides and further utilized.
In Vivoidentification of pharmacological activities ofMalva neglecta Wallr
Authors: Ahmad Shabir , Saeed Khawar , Shahzad Qasim , Dad Rubina
Published: September 2020

The use of medicinal plants for cure, treatment and control of diseases is one of the ancient forms of medical practice in mankind history. The 80% population of underdeveloped nations is still dependent on traditional medicinal remedy for its basic medical needs. Malva neglecta Wallr. is a medicinal plant used for phytotherapy for the treatment of cough, respiratory and digestive problems. The present study was conducted for the identification of pharmacological activity of crude extract of Malva neglecta Wallr. on inflammatory, emesis, and analgesic effect in different In-Vivo moels. For this study we performed hind paw, eddy hot plate, and check emesis methods. In the standard condition methods, 78.05%, 76.75% inhibition in anti-emetic, anti- inflammatory and in analgesic it shows significant effect. Malva neglecta Wallr. crude extract (Mn.Cr) possess anti-inflammatory, analgesic and antiemetic activities.