bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved Quantitative Approach for Monitorization of Gangliosides Structural Diversity in Fungal Cell Factories by LC-MS/MS
Authors: Montero-Bullón Javier-Fernando , Martín-González Javier , Muñoz-Fernández Gloria , Jiménez Alberto , Revuelta José
Published: December 2022

Gangliosides are glycolipids occurring in higher animals, with a sphingoid core in the form of ceramide, bound to a glycan moiety including several units of sialic acid. Gangliosides are involved in important (patho)-physiological processes as components of cell membranes in humans, which has led to intensive study and interest in production strategies. Their structural variability depends on the combination of a sphingoid base, a fatty acyl chain, and an attached oligosaccharide. The combinatorial diversity differs and grows exponentially in synthetic biology approaches, e.g., use of microbial cell factories. A specific analytical platform accounting for this complexity is not available to date. However, quantification of the intermediates of the whole biosynthetic route is needed to boost projects on biotechnological ganglioside production. In this study, a fast high-throughput quantitative LC-MS/MS methodology was developed to cover analysis of gangliosides, with a wider structural perspective adapted to fungal organisms. This work was achieved using metabolically engineered strains that further allowed to test detection in biological complex matrixes. Ganglioside backbones—hitherto uncharacterized—with the five most common fungal sphingoid bases and both simple and hydroxylated fatty acids were subjected to characterization. The addition of glycans to the polar head was also successfully monitored with up to 4 units—corresponding to GD3 which bears two sialic acid units and furthermore represents the common precursor for the whole ganglio-series. This platform represents an improved methodology to study the biochemical diversity associated to gangliosides for natural and metabolically engineered biosynthetic pathways.
Optimization Protocol of the PEG-Based Method for OSCC-Derived Exosome Isolation and Downstream Applications
Authors: Shieh Tzong-Ming , Tseng Yu-Hsin , Hsia Shih-Min , Wang Tong-Hong , Lan Wan-Chen , Shih Yin-Hwa
Published: December 2022

The exosome precipitation method affects the purity of the exosome and the quality of the downstream application. Polymer-based precipitation is a cost-effective method widely used in different research fields. The percentage of the polymer should be modified in different cell types or liquid biopsy before precipitation. This study aimed to optimize the protocol of the poly(ethylene glycol) (PEG)-based approach for extracting oral squamous cell carcinoma (OSCC)-derived exosomes, and its downstream applications. We used 8%, 10%, and 12% PEG to isolate the exosomes from the culture medium and compared the purity with that of the ultracentrifugation method. In addition, we extracted exosomal protein, DNA, and RNA, and tested the cell transfection efficiency for downstream application. The results reveal that 8% PEG and the medium mixture incubated at 4 °C overnight effectively precipitated exosomes of higher purity and more proper size and particle numbers compared with the ultracentrifuge method. PEG-precipitated exosomes cocultured with fibroblasts showed better transfection efficiency compared to exosomes alone. Therefore, 8% PEG is ideal for OSCC-derived exosome isolation and downstream applications. We recommend that the cost-effective PEG precipitation method be used for precipitating exosomes from OSCC cell experiments.
Effect of the COVID-19 Pandemic on the Sense of Belonging in Higher Education for STEM Students in the United States and Mexico
Authors: Morán-Soto Gustavo , Marsh Aradaryn , González Peña Omar Israel , Sheppard Matthew , Gómez-Quiñones José Isabel , Benson Lisa C.
Published: December 2022

The COVID-19 pandemic generated worldwide negative effects on college students’ stress levels and motivation to learn. This research focuses on the lack of development of a sense of belonging in engineering students due to online classes during the pandemic and possible differences experiencing online classes between students from different contexts and cultures. Data were collected from 88 Mexican and 139 U.S. engineering students during the Spring 2021 semester using ten survey items asking students’ perceptions of the effects of taking online courses during the COVID-19 pandemic on their sense of belonging in their major. Quantitative and qualitative analyses were conducted, aiming to determine the effects of taking online classes on students’ sense of belonging in engineering. Findings stressed the poor sense of belonging that engineering students may have after taking online classes during the COVID-19 pandemic when they missed opportunities to develop meaningful relationships with their peers and professors due to the lack of good communication. Consequently, students had uncertainties about successful learning during the pandemic in both Mexico and the U.S. Thus, activities such as accessible office hours, study groups, and meetings with mentors and tutors should be promoted to help students recover from the lack of a sense of belonging in the engineering major generated during online classes due to the COVID-19 pandemic.
Time in Responding to Terrorist Attacks in Cities
Authors: Stelmach Jarosław , Moch Natalia
Published: December 2022

Terrorism is one of the most serious threats today. The perpetrators of the attacks use newer and newer tools and apply new methods of operation. Their goal is to cause fear; therefore, for the media message to be more and more attractive, the terrorists began to attack even more spectacularly. Considering the above, cities conducive to forming clusters of people are attractive places to carry out an attack. To meet the emerging challenges, cities increasingly use modern information and communication technologies, transforming into smart cities. One of the basic assumptions for this is to ensure high safety and public order. Antiterrorist protection is a particular challenge for city authorities. Considering the above, the aim of the research, the effects of which are presented in the article, was to identify and describe the basic features distinguishing selected categories of terrorist attacks carried out in cities. In the course of the research, the duration of the terrorist event was analyzed and the critical relationships between the time and the effectiveness of neutralization and rescue operations at the scene were identified. The research method used, in addition to the observation and analysis of the literature, was a descriptive case study.
Knowledge Sharing Practices for Corporate Sustainability: An Empirical Investigation of Sharing Economy Firms in Japan
Authors: Park Ye-Chan , Hong Paul
Published: December 2022

Qualitative studies of sharing economy research are mostly descriptive case studies in the context of the United States and Europe. Although Asian economies are vibrant and expanding, rarely sharing economy research focuses on Asian contexts. Furthermore, quantitative analysis of sharing economies is rare. For this reason, our research aim is to examine the corporate sustainability of sharing economy companies through qualitative and quantitative analyses. It also shows how knowledge-sharing practices affect corporate sustainability in the context of emerging sharing economy firms in Japan. The contribution of this paper is threefold: (1) to provide a conceptual framework for sharing economy practices in general; (2) to present a specific research model in a Japanese context; (3) to report the qualitative case study findings and discuss the empirical results of testing of hypotheses with statistical validation. The research results suggest that the knowledge creation context has a positive effect on both explorative and exploitative knowledge-sharing practices. Explorative knowledge sharing has a positive effect on sustainability which in turn shows a negative effect on financial performance in the short run but a positive impact in the long run. Theoretical and managerial implications provide valuable insight into how sharing economy firms achieve sustainability goals. Future research issues are also summarized.
Representative versus Natural Values of Public Open Spaces—A Landscape Approach (Szczecin Case Study)
Authors: Sochacka Eliza , Rzeszotarska-Pałka Magdalena , Nowak Grzegorz
Published: December 2022

Apart from interactivity, representativeness (in the meaning of grandness) is the basic and required characteristic of public open spaces. The representativeness of public open spaces (POS) is understood in terms of their ability to portray cities and their inhabitants as a whole. This study considers the historical value of public spaces and determines their contemporary role as spaces for representing cities. Moreover, we explore the relationship between the natural value of such places and their representativeness function. It was necessary to define the criteria determining the representativeness of public spaces, including their physical, semiotic, and functional features. The study was carried out in the midtown zone of Szczecin. The subject of the study is urban landscape objects. The landscape, according to the definition presented by the European Landscape Convention, is part of the land, as perceived by local people and visitors, which evolves through time as a result of being acted upon by natural forces and human beings. The landscape approach used in this research enables an assessment that requires taking into account and comparing many aspects that build the layers of the landscape. Qualitative and quantitative research methods were used to assess the characteristics that distinguish POS in the symbolic, formal, location-related and functional layers and to examine their ecological value. The results of the study generally confirmed our hypothesis: i.e., embedding the studied POS within the city’s tradition—with its strong semiotic connections and with the specific history of the place (genius loci)—increases the space’s range of contemporary, representative functions. At the same time, an apparent decrease in the prestige of the studied POS was observed. Although they originally had high historical value, they either lost key artifacts constituting that identity or were excluded from the main functional and compositional axes of the city. Moreover, this study proves that the representativeness of POS, conditioned by historical value and contemporary functional, spatial, and location features, is generally inconsistent with their high natural value. Still, this inconsistency does not have to be a mean contradiction.
Green Outsourcer Selection Model Based on Confidence Interval of PCI for SMT Process
Authors: Chen Kuen-Suan , Li Feng-Chia , Lai Kuei-Kuei , Lin Jung-Mao
Published: December 2022

Taiwan’s electronics industry usually outsources most of its important components for production to enhance market competitiveness and operational flexibility. The quality of all component products is important to ensure the quality of the final product. In electronic assembly, printed circuit boards (PCBs) are key components that carry other electronic components to provide a stable circuit working environment. Surface Mounted Technology (SMT) is the mainstream technology in electronic assembly plants. Obviously, good SMT process quality is relatively important to the final product quality. The process capability index (PCI) is the most widely used process quality evaluation tool in the industry. Therefore, this paper used the PCI representing quality as the green outsourcer selection tool for the SMT process, derived the confidence interval of PCI to develop a quality evaluation model of green outsourcers, and considered the model as the green outsourcer selection model. Meanwhile, this model can be provided to enterprises, outsourcers, or suppliers to evaluate and improve the process quality of components to ensure the quality of components and final products. Since the selection model is based on confidence intervals, it can reduce the risk of misjudgment due to sampling error.
Control Strategies of Hybrid Energy Harvesting—A Survey
Authors: Othman Akeel , Hrad Jaromir , Hajek Jiri , Maga Dusan
Published: December 2022

In this article, we deal with the problem of Hybrid Energy Harvesting control strategies, while paying attention to their properties and suggesting criteria to assess their suitability for specific energy harvesting techniques, as well as their application in different areas of technology—especially Wireless Sensor Networks and the Internet of Things. Many research works have already been published on the topic of combining resources for Energy Harvesting; nevertheless, a comprehensive review of the control strategies for such systems and a comparison of their most important properties is missing. This is the genesis and the main subject of this article. We have performed a deep research investigation of available resources. We have identified eight different control strategies and defined a set of the most important parameters (including their possible ranges/states) as criteria to be able to compare them. The corresponding sections of this article begin with a general description of the respective strategies and their principles (including generalized schemes), which is followed by specific examples of best practices. The key conclusions of the performed analysis are summarized in a comparison table that allows the readers to make their own conclusions and choices.
Livelihood Capital, Ecological Cognition, and Farmers’ Green Production Behavior
Authors: Ren Jianhua , Lei Hongzhen , Ren Haiyun
Published: December 2022

Green development of agriculture is inevitable to meet the objective demand of rural ecological environment protection and high-quality agricultural development. Livelihood capital is the basic condition for farmers to carry out the activities of production and management, while ecological cognition is the direct motivation for their behaviors. Based on field research data from 436 farm households in 4 counties of Langao, Fuping, Mian, and Yaozhou in Shaanxi Province, China, the study conducted the double-hurdle model (DHM) to empirically analyze the effects of livelihood capital and ecological cognition on farmer’s decision on green production and the degree of green production. The results show that (1) farmers’ livelihood capital is the basic condition that significantly affects farmers’ green production. Specifically, human capital and social capital have a positive contribution to farmers’ green production decision and degree of green production; natural capital and financial capital do not have a significant effect on green production decision, but have a significant positive effect on the degree of green production behavior; physical capital, as farmers’ stock capital, does not have a significant effect on green production behavior. (2) Ecological cognition plays a positive moderating role in farmers’ decisions on green production, but as a subjective cognition, its contribution to the degree of green production is not significant. This paper explores the relationship between livelihood capital, ecological cognition, and farmers’ green production behavior, and provides suggestions for improving farmers’ participation in green production.
Eye Movement Analysis and Usability Assessment on Affective Computing Combined with Intelligent Tutoring System
Authors: Lin Hao-Chiang Koong , Liao Yi-Cheng , Wang Hung-Ta
Published: December 2022

Education is the key to achieving sustainable development goals in the future, and quality education is the basis for improving the quality of human life and achieving sustainable development. In addition to quality education, emotions are an important factor to knowledge acquisition and skill training. Affective computing makes computers more humane and intelligent, and good emotional performance can create successful learning. In this study, affective computing is combined with an intelligent tutoring system to achieve relevant and effective learning results through affective intelligent learning. The system aims to change negative emotions into positive ones of learning to improve students’ interest in learning. With a total of 30 participants, this study adopts quantitative research design to explore the learning situations. We adopt the System Usability Scale (SUS) to evaluate overall availability of the system and use the Scan Path to explore if the subject stays longer in learning the course. This study found that both availability and satisfaction of affective tutoring system are high. The emotional feedback mechanism of the system can help users in transforming negative emotions into positive ones. In addition, the system is able to increase the learning duration the user spends on learning the course as well.
Adverse Effects of Black Carbon (BC) Exposure during Pregnancy on Maternal and Fetal Health: A Contemporary Review
Authors: Goriainova Viktoriia , Awada Christina , Opoku Florence , Zelikoff Judith T.
Published: December 2022

Black carbon (BC) is a major component of ambient particulate matter (PM), one of the six Environmental Protection Agency (EPA) Criteria air pollutants. The majority of research on the adverse effects of BC exposure so far has been focused on respiratory and cardiovascular systems in children. Few studies have also explored whether prenatal BC exposure affects the fetus, the placenta and/or the course of pregnancy itself. Thus, this contemporary review seeks to elucidate state-of-the-art research on this understudied topic. Epidemiological studies have shown a correlation between BC and a variety of adverse effects on fetal health, including low birth weight for gestational age and increased risk of preterm birth, as well as cardiometabolic and respiratory system complications following maternal exposure during pregnancy. There is epidemiological evidence suggesting that BC exposure increases the risk of gestational diabetes mellitus, as well as other maternal health issues, such as pregnancy loss, all of which need to be more thoroughly investigated. Adverse placental effects from BC exposure include inflammatory responses, interference with placental iodine uptake, and expression of DNA repair and tumor suppressor genes. Taking into account the differences in BC exposure around the world, as well as interracial disparities and the need to better understand the underlying mechanisms of the health effects associated with prenatal exposure, toxicological research examining the effects of early life exposure to BC is needed.
Ecotoxicological Effects of the Anionic Surfactant Sodium Dodecyl Sulfate (SDS) in Two Marine Primary Producers: Phaeodactylum tricornutum and Ulva lactuca
Authors: Cruz de Carvalho Ricardo , Feijão Eduardo , Matos Ana , Cabrita Maria , Utkin Andrei , Novais Sara , Lemos Marco , Caçador Isabel , Marques João , Reis-Santos Patrick , Fonseca Vanessa , Duarte Bernardo
Published: December 2022

Sodium Dodecyl Sulfate (SDS) is an anionic surfactant, extensively used in detergents, household and personal care products, as well as in industrial processes. The present study aimed to disclose the potential toxicological effects of SDS exposure under environmentally relevant concentrations (0, 0.1, 1, 3, and 10 mg L−1) on the physiology and biochemistry (photosynthesis, pigment, and lipid composition, antioxidative systems, and energy balance) of two marine autotrophs: the diatom Phaeodactylum tricornutum and the macroalgae Ulva lactuca. A growth rate (GR) reduction in P. tricornutum was observed with a classic dose-response effect towards the highest applied concentration, while a GR increase occurred in U. lactuca. Regarding photochemistry, the decrease in the fluorescence of the OJIP curves and laser-induced fluorescence allowed a better separation between SDS treatments in U. lactuca compared with P. tricornutum. Although all pigments significantly decreased in U. lactuca at the highest concentrations (except for antheraxanthin), no significant variations occurred in P. tricornutum. On the other hand, changes in fatty acid content were observed in P. tricornutum but not in U. lactuca. In terms of classical biomarker assessment, a dose-effect relationship of individual biomarkers versus SDS dose applied; U. lactuca displayed a higher number of biomarker candidates, including those in distinct metabolic pathways, increasing its usefulness for ecotoxicological applications. By evaluating the potential application of optical and biochemical traits, it was evident that the fatty acid profiles of the different exposure groups are excellent candidates in P. tricornutum, concomitant with the characteristics of this anionic surfactant. On the other hand, the results presented by laser-induced fluorescence and some parameters of PAM fluorometry in U. lactuca may be an advantage in the field, offering non-invasive, fast, easy-to-use, high-throughput screening techniques as excellent tools for ecotoxicology assessment.
Real-World Effectiveness of COVID-19 Vaccines against Severe Outcomes during the Period of Omicron Predominance in Thailand: A Test-Negative Nationwide Case–Control Study
Authors: Nittayasoot Natthaprang , Suphanchaimat Rapeepong , Thammawijaya Panithee , Jiraphongsa Chuleeporn , Siraprapasiri Taweesap , Ploddi Kritchavat , Pittayawonganon Chakkarat , Mahasirimongkol Surakameth , Tharmaphornpilas Piyanit
Published: December 2022

Due to the widespread Omicron variant of SARS-CoV-2 in Thailand, the effectiveness of COVID-19 vaccines has become a major issue. The primary objective of this study is to examine the real-world effectiveness of COVID-19 vaccines based on secondary data acquired under normal circumstances in a real-world setting, to protect against treatment with invasive ventilation of pneumonia during January to April 2022, a period when Omicron was predominant. We conducted a nationwide test-negative case–control study. The case and control were matched with a ratio of 1:4 in terms of age, date of specimen collection, and hospital collection specimen and the odds ratio was calculated using conditional logistic regression. Overall, there was neither a distinction between mix-and-match regimens and homologous mRNA regimens against severe symptoms, nor was there a decline of the protective effect over the study period. The third and fourth dose boosters with ChAdOx1 nCoV-19 or mRNA vaccines provided high levels of protection against severe outcomes, approximately 87% to 100%, whereas two doses provided a moderate degree (70%). Thus, this study concludes that current national vaccine strategies provide favourable protective benefits against the Omicron variant. All Thais should receive at least two doses, while high-risk or vulnerable groups should be administered at least three doses.
Legal education and modern challenges
Authors:   Department of Constitutional and Municipal Law, Faculty of Law, Ammosov North-Eastern Federal University, Yakutsk, Stepanova Albina Afanasievna
Published: December 2022

Globalization, internetization, the closed world due to the spread of the coronavirus infection, the introduction of new forms of education, and other challenges of our time have a serious impact on education in general and on the quality of specialist training. The article examines the trends in the development of modern legal education and provides the recommendations for solving and overcoming the problems that arise in the implementation of the modern model of training highly qualified lawyers.
The role of educational programs for training prosecution office employees in resolving global security issues
Authors:   Faculty of Law, Moscow University for the Humanities, Seletskaya, Anastasiya Sergeevna
Published: December 2022

In the current conditions, the main task of prosecution offices is the protection of citizens’ social rights, in particular, by overseeing the implementation of legislation in the social sphere (health care, drug provision, pensions, social insurance, and education). This issue is the subject of the research in this article.
Implementing antibiotic stewardship in high-prescribing English general practices: a mixed-methods study
Authors: Tonkin-Crine Sarah , McLeod Monsey , Borek Aleksandra J , Campbell Anne , Anyanwu Philip , Costelloe Céire , Moore Michael , Hayhoe Benedict , Pouwels Koen B , Roope Laurence SJ , Morrell Liz , Hopkins Susan , Butler Christopher C , Walker Ann Sarah
Published: December 2022

Background

Trials have identified antimicrobial stewardship (AMS) strategies that effectively reduce antibiotic use in primary care. However, many are not commonly used in England. The authors co-developed an implementation intervention to improve use of three AMS strategies: enhanced communication strategies, delayed prescriptions, and point-of-care C-reactive protein tests (POC-CRPTs).

Aim

To investigate the use of the intervention in high-prescribing practices and its effect on antibiotic prescribing.

Design and setting

Nine high-prescribing practices had access to the intervention for 12 months from November 2019. This was primarily delivered remotely via a website with practices required to identify an ‘antibiotic champion’.

Method

Routinely collected prescribing data were compared between the intervention and the control practices. Intervention use was assessed through monitoring. Surveys and interviews were conducted with professionals to capture experiences of using the intervention.

Results

There was no evidence that the intervention affected prescribing. Engagement with intervention materials differed substantially between practices and depended on individual champions’ preconceptions of strategies and the opportunity to conduct implementation tasks. Champions in five practices initiated changes to encourage use of at least one AMS strategy, mostly POC-CRPTs; one practice chose all three. POC-CRPTs was used more when allocated to one person.

Conclusion

Clinicians need detailed information on exactly how to adopt AMS strategies. Remote, one-sided provision of AMS strategies is unlikely to change prescribing; initial clinician engagement and understanding needs to be monitored to avoid misunderstanding and suboptimal use.
Monotongação e Ditongação: a relação oral-escrita no contexto escolar
Authors: Moura Magna Andrizze de Araújo , Silva Jr. Leônidas
Published: December 2022

O presente artigo tem como objetivo avaliar os processos fonológicos da monotongação e ditongação a partir da influência da oralidade sobre a escrita de alunos do Ensino Fundamental II. No aporte teórico, nos embasamos nos estudos de Aragão (2014, 2000) e Haupt (2011) sobre os fenômenos via modelo laboviano e Teoria de Exemplares respectivamente, além de Lima e Silva Jr. (2015), que propõem um modelo didático-intervencionista para o contexto escolar. Na Metodologia, realizamos atividades antes e após a aplicação de uma proposta de intervenção (um treinamento) a fim de verificar se esse treinamento alterou significativamente o desempenho dos alunos. Nossos resultados apontam melhorias significativas para ditongação e discretas para monotongação mesmo após o treinamento. Este cenário sugeriria que a monotongação pode estar correlacionada com a percepção fonética do aluno e que se faz necessário atividades com maior interação entre treino oral e escrita.
Avaliação e descrição da oralidade narrativa na escola primária: o que as produções dos alunos nos dizem sobre os efeitos das sequências didáticas
Authors: Gagnon Roxane , Bourdages Rosalie , Pippus Marques Laura
Published: December 2022

As dificuldades relacionadas ao ensino da oralidade podem ser parcialmente explicadas pela falta de critérios de avaliação bem definidos (NONNON, 1999, 2006) e pela existência de modelos imprecisos (XXXX, 2020). Com o suporte de um instrumento de avaliação da oralidade narrativa, nós analisamos um corpus de narrativas orais espontâneas realizadas por 32 alunos entre 6 e 10 anos em dois momentos: um, antes da apresentação de uma sequência didática sobre o conto, e um, depois. Análises quantitativas e qualitativas foram efetuadas com o objetivo de descrever as narrativas e de verificar se os critérios utilizados e reunidos em uma tabela atestam variações tanto no nível interindividual quanto no nível de progresso individual, sinais de sua eficácia para o ensino e para a pesquisa. As histórias produzidas após a sequência didática são mais longas e apresentam uma melhor construção narrativa, mas o vocabulário não é mais rico, nem as estruturas gramaticais são mais complexas do que naquelas produzidas antes da sequência didática. Nossas análises qualitativas incluem cruzamentos entre as dimensões narrativas e linguísticas, e sugerem a presença de perfis de contadores de contos. Os resultados permitem elaborar recomendações quanto aos objetivos de aprendizagem e à organização do ensino da oralidade no primário.
Aspectos bioéticos e a fisioterapia nos cuidados paliativos oncológicos
Authors: Costa Sâmia Aimê Flor da , Ribeiro Ingrid Ribeiro de , Barroso Leandra Cristina Coelho , Rocha Letícia de Barros , Dias George Alberto da Silva , Soeiro Ana Cristina Vidigal
Published: December 2022

Objetivo. Identificar os aspectos bioéticos inseridos na prática fisioterapêutica nos cuidados paliativos oncológicos. Método. Trata-se de um estudo exploratório, descritivo e qualitativo, com participação de 11 fisioterapeutas de um hospital oncológico, os quais responderam a um questionário semi-estruturado aplicado de forma presencial. Resultado. Os participantes reconhecem a importância da Fisioterapia na equipe de saúde, e apontaram que as intervenções fisioterapêuticas têm um impacto positivo na qualidade de vida do paciente. Entretanto, os achados revelaram lacunas na formação prévia em cuidados paliativos, o que resulta em desafios que precisam ser enfrentados na relação com o paciente, família e equipe. As possibilidades e limitações de intervenção também foram associadas ao quadro clínico do paciente e às habilidades de relacionamento do fisioterapeuta, tanto na relação com o paciente e familiares, como também com a equipe. A aproximação com os princípios e diretrizes dessa abordagem também demonstraram importância nas situações enfrentadas, particularmente naquelas que envolvem a morte e o morrer. Conclusão. Os achados demonstram que a Bioética tem muito a contribuir para a atuação da Fisioterapia nos cuidados paliativos oncológicos, particularmente nos cuidados em fim de vida.
Ausência de lei de crime de ódio: problemáticas para o enfrentamento da Lgbtfobia
Authors: Nabhan Francine Adilia Rodante Ferrari , Sousa Dayra Alexandrita Ferreira
Published: December 2022

O presente trabalho, por meio de metodologia de pesquisa bibliográfica, buscou discorrer sobre as consequências enfrentadas pela comunidade LGBT causadas pela ausência de lei de crime de ódio no Brasil, construindo uma breve contextualização histórica sobre os direitos conquistados por essa população, evidenciando as mazelas que ainda a tange de forma a buscar suas raízes e discutir as maneiras como uma lei que reconhecesse a problemática pode levar a diminuição das violências sofridas pela comunidade.
Um mar de (re)existência: a arte dos/nos corpos LGBTQIA+ com deficiência em uma história de vida
Authors: Yamaguti Emerson Takumi , Mendonça Viviane Melo de , Da Silva João Henrique
Published: December 2022

Os corpos de pessoas Lésbicas, Gays, Bissexuais, Transgêneros, Queers, Intersexuais, Assexuais e outros (LGBTQIA+) com deficiência constituem-se como de um grupo que foi historicamente marginalizado e silenciados, mas que resistem e lutam junto aos movimentos sociais contra o pensamento hegemônico e a favor da ressignificação das identidades, sejam elas de raça, de gênero, de classe ou orientação sexual, dando voz e visibilidade aos sujeitos que são considerados como grupos minoritários. As pesquisas sobre as pessoas com deficiência da comunidade LGBTQIA+ é recente e há escassez de produções específicas envolvendo LGBTQIA+ com deficiência na arte. Dessa maneira, este estudo objetiva refletir sobre a trajetória de vida de uma pessoa LGBTQIA+ com deficiência, buscando, em suas memórias, identificar os elementos de silenciamento, resistência e transformação de vida através da arte. Trata-se um trabalho que utiliza a história oral na modalidade história oral de vida, fundamentando-se nos estudos feministas (decolonial e interseccional). Participou da pesquisa um homem adulto LGBTQIA+ com deficiência e ator que possui 29 anos de idade e frequentou a rede regular de ensino e escolas de teatro no estado de Rio de Janeiro. Conclui-se de sua história de vida que as artes possibilitaram autoconhecimento, descoberta da sexualidade, segurança, fortalecimento de suas identidades e enfrentamento do capacitismo estrutural e cultural. Por outro lado, verificou-se que houve silenciamento por ser um corpo gay com deficiência. Por fim, ressalta-se que a trajetória de vida de Alcides sinaliza a necessidade de problematizar o papel da Arte na inclusão de corpos LGBTQIA+ com deficiência na sociedade.
CLINICAL CASE OF SIMULTANEOUS RADICAL TREATMENT OF TETRALOGY OF FALLOT WITH MAJOR AORTOPULMONARY COLLATERAL ARTERIES
Authors:   Center of Modern Medicine «Mediterra» Institute of Surgery LLP, Almaty, Kazakhstan, Kuatbekov K.N. , Egizekov A.L. , Musagaliev D.T. , Maslov T.V. , Sydykov E.T. , Mishin A.V. , Baizhigitov N.B. , Suieubekov B.Y
Published: December 2022

Tetralogy of Fallot (TOF) combined with major aortopulmonary collateral arteries (MAPCA) is a severe congenital heart defect due to the combination of a triad of cardiac malformation withan additional vascular anomaly of the small circulatory system. To date, there is no single accepted standard in which sequence and according to which criteria radical surgical correction of combined anomalies is indicated. This paper describes a clinical case of simultaneous opentreatment of TOF and endovascular occlusion of the MAPCA in an 8-month old child. Based onthe evidence base of a large study, our patient belonged to the group where after TOF correction the therapeutic way of MAPCA treatment was used at first, which was ineffective in 38% and led to surgical methods of MAPCA occlusion. Choosing the way of simultaneous simultaneoussurgical treatment of two pathologies allowed us to minimize postoperative risks and achievegoodclinical results.
MODERN ASPECTS OF DIAGNOSTICS OF AUTOIMMUNE DISEASES OF THE THYROID GLAND
Authors:   Scientific Center of Surgery named after Academician M.A. Topchubashov, Baku, Republic of Azerbaijan, Sadykhov F.G.
Published: December 2022

Objective.This research ismeant to study the features of the clinical course and to developanoptimal algorithm for the diagnosis of autoimmune thyroiddiseases. Material and methods.The work is based on the examination and treatment data of 481 patients with autoimmune diseases of the thyroid gland, treated in the clinic.Diagnosis and treatment results of 481 patients were analyzed to develop an optimal algorithm for diagnosingautoimmune thyroiditis.The differential diagnostic capabilities of clinical, laboratory, and morphological examination methods of patients withautoimmune thyroiddiseases have been specified.The study of long-term results of treatment was carried out on 340patients, taking into account the various methods of treatment they underwent. Results.The analysis of existing diagnostic tools and methods allowed us to develop an optimal algorithm for diagnosingautoimmune thyroiddiseases, which is a complex of clinical, laboratory, and morphological methods that can reliably verify the diagnosis of autoimmune thyroiditis. Based on the examination results, it is possible to predict the likelihood of surgical treatment and to identify a group of patients in whom autoimmune processes can progress in the thyroid residue, contributing to the development of postoperative recurrence of the disease or causing its atrophy. Conclusion. Based on the study’s results, a rational algorithm for diagnostic search has been developed. The proposed algorithm allows, in the shortest possible time, to identify the presence of a form of autoimmune thyroiddisease and to determine the optimal tactics to treat patients withautoimmune thyroiditis based on clinical, laboratory, immunological tests and instrumental examinations.
Implementasi CRM (Customer Relationship Management) Menggunakan VTiger CRM Pada Perusahaan (Studi Kasus: CV. Maha Sari)
Authors: Mahatma Wicaksana Nyoman Bandem
Published: December 2022

Untuk memenangkan persaingan dan mempertahankan bisnis di era yang sangat kompetitif, usaha kecil dan menengah harus menerapkan aplikasi teknologi informasi yang dapat diandalkan untuk mendukung basis data pelanggan, produksi dan penjualan serta manajemen pemasaran untuk menjalin komunikasi yang baik dengan pelanggannya. Salah satu aplikasi teknologi informasi yang memungkinkan untuk usaha kecil dan menengah adalah Customer Relationship Management yang dikenal dengan CRM. Penelitian ini menghasilkan pemodelan proses bisnis usulan yang dikembangkan dari proses bisnis existing, serta implementasi proses bisnis usulan pada aplikasi E-CRM yakni VTiger CRM. Aplikasi VTiger CRM merupakan salah satu aplikasi E-CRM yang dapat dimanfaatkan perusahaan dalam upaya penerapan CRM, yang didalamnya terdapat berbagai modul yang siap digunakan. Beberapa modul yang dimiliki aplikasi VTiger CRM yakni modul Campaign, Sales, Order, Invoice, Tickets, Products, Contacts, Reports hingga sebuah modul hasil dari kustomisasi yang dilakukan pada penelitian ini dengan tujuan untuk menyesuaikan dengan kegiatan yang dilakukan perusahaan yakni modul kuesioner.
MOHALLA (OR COMMUNITY/ NEIGHBORHOOD) CLINICS TO REINFORCE PRIMARY HEALTHCARE IN DELHI, INDIA: A SYSTEMATIC REVIEW BASED ON PRISMA 2020 GUIDELINES
Authors: Kumar Kaushal
Published: December 2022

“Mohalla” in Hindi language means community or neighborhood. In July 2015, government of Delhi started establishing Mohalla (or community/neighbourhood) clinics (MCs) for strengthening primary healthcare services in Delhi, India. Primary objectives these clinics include making primary care accessible and affordable, reducing burden on tertiary care facilities etc. This article contains a review of past publications concerned with MCs to assess their performance. A systematic review based on PRISMA 2020 guidelines was carried out and database search was completed on 8 Feb, 2022. A total of 24 studies were finally selected for review. The review revealed that MCs have the potential to make primary care services accessible and can help in achieving universal health coverage. These clinics provide cost-effective primary care services and avoid overcrowding in big hospitals. MCs circumvent self-medication practices and are highly effective in low-income settings. To improve efficiency of MCs, it is suggested to strengthen health workforce and expansion of MCs beyond primary care. Additionally, there is a need of functional referral system along with launching telemedicine services at MCs
HRPD and TEM Study of P/M 58Fe17Cr25Ni Austenitic Stainless Steel Synthesized by Spark Plasma Sintering
Authors: Mustofa Salim , Dani M , Parikin Parikin , Sudiro Toto , Hermanto Bambang , Adhika D. R. , Insani Andon , Syahbuddin Syahbuddin , Hino Takanori , Huang C. A.
Published: December 2022

58Fe17Cr25Ni austenite stainless steel has been fabricated using metal powder through sintering with a spark plasma at temperatures of 900 and 950°C for 5 minutes. High purity Fe, Ni and Cr powders were used as materials for this steel. Before sintering, the powder was mixed in a milling equipment which was processed for 5 hours, then it is formed into a coin by pressing it under a load of 25 tons. High resolution powder neutron diffractometer was used for identifying the crystal structure in the 58Fe17Cr25Ni austenitic stainless steel. The sintering process at temperatures of 900C and 950°C generally forms microstructure having matrix of equiaxed austenite grains, with a crystal structure of face-centered cubic which included in the Fm3m space group. Some particles with high Cr content, a'-Cr, are distributed in all austenite grains. The austenite grains seen in the 58Fe17Cr25Niaustenitic stainless steel sintered at 900°C are twin grains. Dislocations, slip planes and bands are also existed in those grains. These defects are expected to decrease with increasing sintering temperatures up to 950° C. This change was followed by the appearance of air bubbles and sub-grains as the dominant sub-structures in the 58Fe17Cr25Ni austenitic stainless steel sintered at 950°C.
Automation in pharmacovigilance: artificial intelligence and machine learning for patient safety
Authors: V C.Randeep Raj , P Divya , A Susmita , P Sushmitha , Ch Ramya , K Chandini
Published: December 2022

Automation promises to be a game- change for pharmacovigilance decreasing the cost of case reporting and improving data quality to truly add value, including signal detection in drug safety. Pharmacovigilance analytic and benefit – risk assessment.Technology advances are playing a major role in pharmaceutical PV strategy updates. For example more companies are looking towards cloud- based solutions, mobile applications, robotic automation, artificial intelligence and big data analytics as a vital part of clinical safety and regulatory operations in the pharmaceutical industry. Applying innovative technology automation tools and processes to PV strategies is now a critical requirement for managing the safety of pharmaceutical products. The role of artificial intelligence and machine learning in pharmacovigilance can enhance the productivity in identification, detection, management and reporting of ADRs. The main objective ofArtificial intelligence is meant to challenges to implementing intelligent automatic solutions include finding / having appropriate training data for machine learning models and the need for harmonised regulatory guidance. AI can analyse and interpret data at lightning speed, never gets tried or sick and can simply work by 24/7. Thousands of adverse effects are processed every month by ICSR in PV that incudes native automation and standalone technologies like AI and ML that reduce the manual effort.
Usability of University Websites as Information Sources: A Review and Synthesis Based on 2021 Publications Indexed in Scopus Database
Authors: Yap Chee Kong , Hisyamuddin Hashim  , Muhammad Hakim Ainuddin  , Mohd Amiruddin Abd  Rahman  , Khairul Adib Yusof  , Norizah Abdul Rahman  , Naszroul Haqimee Rahmat  , Amir Hamzah  Abd. Ghafar  , Norlida Md Noor  , Siti Hajar Alias  , Norzaina Darus  , Jivananthan Arumugam  , Noor Nashrin Arlina Anas  , Bimo Ario Tejo  , Wan Mohd Syazwan  , Zanariah Abdul Majid  , Halimah Mohamed Kamari  , Khamirul Amin Matori  , Muskhazli Mustafa  , Nor Azwady Abd Aziz  , Mohd Basyaruddin Abdul Rahman  , Khalid Awadh Al-Mutairi  , Krishnan Kumar  , Geetha Subramaniam  , Wan Hee Cheng
Published: December 2022

Universities' identities and institutional images are showcased on their websites to the rest of the world. Nowadays, many university websites (UW)s have been well-investigated for usability improvement for all users in general. This study aims to review the publications indexed in the Scopus database in 2021 using the search term 'University Websites' and to synthesize the main information being discussed in the manuscripts. Two main reasons why only papers published in 2021 were selected for this study. Firstly, in terms of the number of publications (N = 456) indexed in Scopus from 1996 to 2021, the 2021 publications are the most recent complete year. Secondly, 2021 topped the list of publications along with 2020. For the year 2021, a total of 58 publications were found in the Scopus database as of February 26, 2022. After screening all the papers, only 39 papers were used for this quantitative analysis. The present systematic review presented three major trends. Firstly, the publications on the UWs are expected to be higher in near future aligned with the speed of Industry 4.0 development worldwide. Secondly, there is a total of 24 countries and 1 region (Latin America) found in this review, with Indonesia leading the list with 8 publications. Thirdly, all the papers aimed to identify the obstacles and recommended ways and room for future improvements for all users regarding their UWs. This review paper highlighted the importance of having effective and up-to-date websites from social and economic viewpoints. It can be synthesized here that continual improvements in the knowledge of the effective usability of a UW can sustain a university's reputation and ranking ultimately.
Evaluation of Professional Development Programmes for Art Teachers in Kwahu-South District Senior High Schools in Ghana
Authors: Ohene Sefah Joseph  , Mumuni Zakaria Fusheini  , Benjamin Semenyo Lifeson  , Henry Ofosu Ameyaw
Published: December 2022

The present study aimed to identify and describe the Professional Development Programmes available for Art Teachers in the Kwahu-South District Senior High Schools and to evaluate how authorities in the Kwahu-South District, organize Professional Development Programmes for Art teachers in the Senior High Schools. Qualitative and evaluation research designs were used. The population for the study consisted of 260 teachers at Kwahu-South District Senior High Schools. The population consisted of Heads of these schools, the Art and Culture Coordinator and the Human Resource Manager (HRM) at the Kwahu-South District education office. Out of the 260 population, only 32 were sampled for this study. Interviews, document analysis and focus group discussion were the instruments used in collecting the data. At the end of the study, it was realized that further studies, workshops, conferences and in-service training are the most common form of Professional Development Programmes that are available to teachers. The other Professional Development Programmes such as coaching, symposium, job rotation and seminar were the least and less attended programmes mentioned among the teachers. Therefore, it is recommended that the government and education stakeholders reconsider PD programmes in their action plans.
The Effect of COVID-19 Pandemic on the Academic Performance of Nursing Students
Authors: Joy Johnson Agbo  , Tolulope Oluwaseun Onayemi  , Edo Great Iruoghene
Published: December 2022

The purpose of this study was to discover how the COVID-19 pandemic has influenced the academic performance of nursing students and the challenges faced while trying to adapt to the online learning era. A total of 144 respondents filled out the online questionnaire. Convenience sampling was considered the sampling method for the study. Online Google questionnaires were administered in accordance with the COVID-19 precautions being taken by the government to encourage social distancing thereby contributing to minimizing the spread of the virus. 105 of the study participants were female nursing students while very few of them were male (39). The outcome of the research showed that the challenges faced by nursing students were issues of limited time, network glitches and inability to cope when studying online. Those who have a high rating for online education want online education to continue while those that had low ratings for online learning were below average in the academic performance. Online learning for schools is not going away soon, so it should be made as convenient and easily accessible as possible. It is also recommended that students are allowed to give feedback as often as possible in the course of their online education.
Scratch y TEA: Desarrollo lúdico de las habilidades sociolingüísticas
Authors: Ruiz-Calzado Inmaculada
Published: December 2022

El presente estudio pretendió identificar las características sociolaborales de los docentes que influyen en el uso del programa Scratch como estrategia que favorece el desarrollo de las habilidades sociolingüísticas en alumnado con TEA. La metodología utilizada fue cuantitativa. Se trató de un estudio de caso llevado a cabo en un centro educativo público de la provincia de Córdoba (España). El instrumento utilizado fue un cuestionario cumplimentado por docentes de Educación Primaria y Educación Secundaria. Los resultados más interesantes evidenciaron el incremento de la motivación del alumnado TEA mediante la adaptación de las actividades a través del programa Scratch.