bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR YANG MEMPENGARUHI PEMILIHAN IUD PASCA PLASENTA PADA WUS DI PUSKESMAS WILAYAH KOTA MATARAM
Authors: Kisid Kristiani
Published: May 2023

The use of the Kb method is expressed by the Contraceptive Prevalence Rate (CPR). Based on Riskesdas (2013), the proportion of family planning use in risk groups, namely the group of married women aged 15-19 years, is 46%, this figure is still lower than the 2014 RPJM target of 60.1%. Younger married women use more modern short-term contraceptives such as injections and birth control pills, while older women use more long-term contraceptives such as IUD and sterile (BKKBN et al., 2012). The purpose of this study was to determine the description of the user profile and what factors influence the selection of post-placental IUDs in fertile aged women in the PKM, Mataram City area. This research is a descriptive analytic study. With a case control research design which is an analytic survey (survey) that concerns how risk factors are studied using a retrospective approach. The sample in this study was 40 respondents who were divided into 2 groups, namely 20 respondents for the user group and 20 respondents for the control group. The user profile of the respondents in this study is the post-placenta IUD which is most widely used in respondents with the age group of 20 - 35 years, namely a number of 19 respondents (95%). Most of them came from high school education level with a number of 15 respondents (75%). Most of them came from unemployed mothers / housewives, namely 17 respondents (85%). With the highest number of parity is multiparous, namely 12 respondents (60%). And all respondents 20 respondents (100%) have the goal of family planning is to delay pregnancy. There is a significant relationship between perceptions and attitudes with the use of the Post Placenta IUD in women in the working area of ??Puskesmas in Mataram City
Rencana Kebutuhan Tenaga Kesehatan Dokter Umum Puskesmas Di Kabupaten Bangli Tahun 2019
Authors: Ni Luh Sri Niteri
Published: May 2023

Salah satu sumber daya di bidang kesehatan yang sangat strategis adalah Sumber Daya Manusia Kesehatan (SDMK). Untuk itu perencanaan kebutuhan SDMK yang mengawali aspek manajemen SDMK secara keseluruhan harus disusun sebagai acuan dalam menentukan pengadaan yang meliputi pendidikan dan pelatihan SDMK, pendayagunaan SDMK, termasuk peningkatan kesejahteraannya, dan pembinaan serta pengawasan mutu SDMK. Ketersediaan tenaga kesehatan dokter umum masih menjadi sorotan penting  terkait jenis, jumlah, dan penyebaran yang tidak merata. Standar kebutuhan tenaga dokter umum puskesmas yang digunakan oleh Dinas Kesehatan Kabupaten Bangli yakni berdasarkan Analisis Beban Kerja (Permenkes No. 33 Tahun 2015 Tentang Pedoman Penyusunan Perencanaan Kebutuhan Sumber Daya Manusia Kesehatan). Aplikasi yang digunakan dalam penyusunan kebutuhan SDMK yaitu program penyusunan Renbut dengan metode ABK dan Standar Ketenagaan Minimal. Simpulan: Kondisi ketersediaan, kebutuhan dan distribusi SDMK Dokter Puskesmas di Kabupaten Bangli masih kurang karena kebutuhan yang bervariasi dan penyebaran SDMK yang tidak merata. Essay ini diharapkan menjadi masukan khususnya kepada Dinas Kesehatan Kabupaten Bangli dalam perencanaan tenaga kesehatan khususnya dokter umum di puskesmas.
PERBANDINGAN HARAPAN DAN KEPUASAN PASIEN PRAKTIK DOKTER GIGI DENGAN IMPORTANCE DAN PERFORMANCE MATRIX
Authors: Utami Cokorda istri mira cipta
Published: May 2023

Setiap pasien gigi yang mengunjungi suatu unit pelayanan kesehatan gigi tentu mempunyai keinginan atau harapan untuk mendapatkan kepuasan terhadap pelayanan kesehatan gigi sesuai dengan yang diinginkannya. Hasil penelitian di klinik-klinik gigi di Kota Denpasar menunjukan bahwa 51,5% pasien belum sepenuhnya terpuaskan oleh kualitas pelayanan yang didapat. Hal tersebut disebabkan karena harapan pasien terhadap pelayanan kesehatan belum terpenuhi sepenuhnya. Tujuan dilakukan penelitian ini untuk mengetahui perbandingan harapan dan kepuasan pada pasien praktek dokter gigi perorangan dengan metode importance dan performance matrix di Kota Denpasar. Rancangan cross-sectional eksploratif yang dilakukan di praktek dokter gigi di Kota Denpasar dengan 200 reponden. Metode sampling yang digunakan adalah consecutive sampling. Instrumen yang digunakan pada penelitian ini adalah kuesioner untuk mengukur persepsi pasien tentang kepuasan pasien atas kualitas pelayanan praktek dokter gigi perorangan di Kota Denpasar. Jawaban responden disediakan dalam 2 (dua) sisi, sisi pertama digunakan untuk memberi jawaban atas importance (harapan) dan sisi lainnya disediakan untuk jawaban atas performance (kinerja). Dilakukan analisis menggunakan Importance-Performance Matrix. Rata-rata pada dimensi kualitas pelayanan berdasarkan harapan dan kepuasan pasien praktek dokter gigi perorangan dengan metode importance dan performance matrix di Kota Denpasar ditemukan rata-rata tertinggi pada dimensi effective (59,98%) dan rata-rata terendah pada dimensi efficient (55,20%). Hasil penelitian juga menunjukan nilai rata-rata importance (3,33) lebih tinggi dari performance (1,90). Dapat disimpulkan bahwa harapan pasien terhadap kualitas pelayanan masih lebih tinggi dibandingkan kepuasan yang didapatkan. Disarankan dokter gigi pada praktek perorangan di Kota Denpasar disarankan untuk memperbaiki dimensi effective, efficient, accessible dan safe yang masih belum sesuai dengan harapan pasien.

Kata Kunci: Kepuasan Pasien, Harapan Pasien, Metode Importance dan Performance Matrix, Praktik Dokter Gigi
PIJAT OKSITOSIN UNTUK MENINGKATKAN PRODUKSI ASI PADA IBU POST PARTUM
Authors: Alfiatun Alfiatun , Aulya Yenny , Widowati Retno
Published: May 2023

ABSTRACT:  According to the Data and Information Center of the Ministry of Health 2017, exclusive breastfeeding in Indonesia is only 35%. Based on data at RSUD dr. Chasbullah Abdulmadjid Bekasi City In the period March-April 2021, there were 78 post partum mothers, and about 20% whose breast milk did not come out smoothly. Oxytocin massage is a massage in the cervical spine area, back or along the spine (vertebrae) to the fifth to sixth costae bones is known to accelerate the work of the parasympathetic nerves to supply commands to the back of the brain so that oxytocin comes out.Purpose: To determine the effect of oxytocin massage on increasing breast milk production in post partum mothers at dr. Chasbullah Abdul Madjid Bekasi City in 2021.Methods: This study used a quasi-experimental method with pre-test and post-test designs without control group on 20 postpartum mothers as respondents. Oxytocin massage was performed for 5 minutes 2 times a day for 2 days. Data analysis used paired sample t-test with an alpha value of 0.05.Results: The average score of milk production before oxytocin massage was 2.0 and after oxytocin massage was 6.5. Paired sample t-test results produce in a significant (2-tailed) value of 0.000.Conclusion: There is a significant difference in the mother's milk production before and after oxytocin massage.Suggestion: Midwives can apply oxytocin massage to facilitate milk production in post partum mothers.
PENGARUH KONSUMSI JUS SEMANGKA TERHADAP PENINGKATAN KADAR HEMOGLOBIN PADA IBU HAMIL TRIMESTER III DI WILAYAH KERJA UPTD PUSKESMAS PRINGKASAP KABUPATEN SUBANG TAHUN 2021
Authors: Agus Rindi Agustianingsih , Yenny Aulya  , Retno Widowati
Published: May 2023

Abstrak 

Anemia merupakan keadaan kadar hemoglobin (Hb) dalam tubuh di bawah nilai normal sesuai kelompok orang tertentu. Pada wanita hamil anemia dapat meningkatkan frekuensi terjadinya komplikasi pada kehamilan, persalinan, resiko kematian maternal, prematur dan BBLR. Penelitian ini bertujuan untuk mengetahui peningkatan kadar Hb ibu hamil trimester III. Penelitian ini menggunakan metode quasi eksperiment dengan rancangan pre-test post-test with two group design pada 30 ibu hamil trimester III sebagai responden yang terdiri dari 15 orang kelompok kontrol yang mengonsumsi Fe dan 15 orang kelompok eksperimen yang konsumsi tablet Fe dan jus semangka. Jus semangka sebanyak 250 ml dikonsumsi ibu dalam kelompok intervensi setiap hari selama 14 hari. Data dianalisis dengan paired test dan independent t test. Hasil penelitian menunjukkan pada kelompok kontrol sebelum minum tablet Fe adalah rata-rata Hb 10,21 g/dl dan sesudahnya 11,27 g/dl. Pada kelompok yang konsumsi tabket Fe dan jus semangka, rata-rata Hb sebelumnya adalah 10,08 g/dl dan sesudahnya 11,23 g/dl. Hasil independent t test menunjukkan P=0,000 (P<0,05). Simpulan pada penelitian ini ibu hamil trimester III yang konsumsi tablet Fe dan jus semangka, kadar Hb meningkat lebih tinggi secara signifikan dibandungkan dengan ibu yang konsumsi hanya tablet Fe saja. Diharapkan ibu hamil dengan anemia dapat konsumsi tablet Fe ditambah jus semangka untuk meningkatkan kadar Hb.
Analisis Susu Kedelai Terhadap Produksi Asi Pada Ibu Nifas di Wilayah Kerja Puskesmas Kertasari Bandung
Authors: - Desi sri priyani , Suprihatin  , Jenny Anna Siauta
Published: May 2023

Abstrak

Latar Belakang: Provinsi Jawa Barat tahun 2019 jumlah bayi yang diberi ASI eksklusif sebesar 63,35% adapun Puskesmas Kertasari Kabupaten Bandung cakupan ASI eksklusif tahun 2020 sebesar 67,8%. Hasil studi pendahuluan pada 10 ibu menyusui dengan ASI yang lancar mengatakan bahwa selama ini ibu berusaha meningkatkan produksi ASI dengan mengkonsumsi susu kedelai. Tujuan: Mengetahui analisis konsumsi susu kedelai terhadap peningkatan produksi ASI pada ibu nifas di wilayah kerja Puskesmas Kertasari Bandung. Metodologi: Penelitian ini merupakan penelitian kualitatif. Sampel pada penelitian ini adalah ibu nifas (5 orang) sebagai informan utama, keluarga (5 orang) dan bidan desa (5 orang) sebagai informan pendukung dengan tehnik purposive sampling. Instrumen penelitian menggunakan wawancara mendalam. Analisis data menggunakan model interaktif Miles dan Huberman. Hasil Penelitian: faktor internal yang memengaruhi produksi ASI diantaranya pengetahuan, penggunaan alat kontrasepsi, pola makan, frekuensi meyusui, kondisi payudara, perilaku ibu dalam upaya peningkatan produksi ASI dan kondisi psikologis. Faktor eksternal yang memengaruhi produksi ASI diantaranya faktor persalinan, pendapatan keluarga dan dukungan keluarga. Peran bidan dalam upaya peningkatan produksi ASI baik. Susu kedelai dapat meningkatkan produksi ASI. Terdapat perbedaan peningkatan produksi ASI pada ibu menyusui sebelum dengan sesudah mengkonsumsi susu kedelai ditandai dengan berat badan bayi mengalami kenaikan. Simpulan dan Saran: Produksi ASI dipengaruhi oleh faktor internal dan faktor eksternal dan salah satu faktor eksternal non farmakologi yang dapat meningkatkan produksi ASI adalah susu kedelai. Diharapkan ibu menyusui dapat mengkonsumsi susu kedelai secara rutin selama menyusui agar dapat meningkatkan produksi ASI sehingga bayi ibu mendapatkan ASI eksklusif.
GAMBARAN SISTEM PENYIMPANAN REKAM MEDIS DALAM MENINGKATKAN MUTU PELAYANAN DI RUMAH SAKIT BHAYANGKARA KOTA MATARAM
Authors: Istiqomah Ria Rahmatul , Ainun Hasril , Purnama Heru
Published: May 2023

Rumah sakit merupakan institusi kesehatan yang dituntut untuk dapat memberikan layanan yang bermutu, bukan hanya dari pelayanan medis tetapi juga dari informasi kesehatan, yang dapat berguna sebagai alat informasi dasar dalam upaya peningkatan mutu pelayanan kesehatan di rumah sakit. Unit rekam medis merupakan salah satu unit yang vital dalam pelayanan kesehatan di rumah sakit. Tanggung jawab dari unit rekam medis dan staf medis yang bersangkutan meliputi pengelolaan isi rekam medis termaksud di dalamnya kelengkapan isi, kebijakan isi, kebijakan penyimpanan, pemusnahan dan kerahasiaan, kepemilikan, pemanfaatan, dan pengorgnisasian

Tujuan penelitian adalah untuk mengetahui sistem penyimpanan berkas rekam medis dalam meningkatkan mutu pelayanan di Rumah Sakit Bhayangkara Kota Mataram. Metode penelitian menggunakan metode deskriptif kualitatif Subyek penelitian dari penelitian ini adalah petugas perekam  medis dan informasi kesehatan  sebanyak 5 orang yang merupakan individu dengan tingkat pendidikan,jenis kelamin,usia,pengalaman kerja yang berbeda-beda dan di sesuaikan dengan tupoksi kerja tenaga perekam  medis di Rumah Sakit Bhayangkara Kota Mataram.

Hasil penelitian menunjukkan bahwa system penyimpanan rekam medis di rumah sakit bhayangkara menggunakan system sentralisasi dengan system penjajaran menggunakan angka akhir. Sedangkan system penomoran menggunakan system unit yang sudah secara otomatis melalui system informasi rumah sakit (SIRS). System pendistribusiannya berkas masih dilalukan dengan cara manual dan masih ditemukan berkaas rekam medis yang masih tidak tersimpan di rak berkas rekam medis.
Pengaruh Paparan Pestisida Terhadap Kadar Kreatinin dan Ureum Pada Petani Di Desa Tanjung Kabupaten Lombok Utara
Authors: Goes Rai Ida Bagus Rai Wiadnya , Lidia Febrianisa  , Lale Budi Kusuma Dewi
Published: May 2023

Latar Belakang : Penggunaan pestisida yang tidak tepat dapat memberikan akibat samping keracunan. Beberapa penelitian yang mempelajari pengaruh pestisida terhadap manusia memperlihatkan bahwa sebagian besar pestisida berpotensi sebagai penyebab terjadinya berbagai gangguan kesehatan salah satunya adalah  kerusakan ginja karena pestisida bersifat netrotoksik. Salah satu parameter yang biasanya diperiksakan untuk mengetahui fungsi gangguan ginjal adalah kadar ureum dan kreatinin serum.

Tujuan Penelitian : Mengetahui pengaruh paparan pestisida terhadap kadar kreatinin dan ureum pada petani di Desa Tanjung, Kabupaten Lombok Utara.

Metode Penelitian : Penelitian ini merupakan survei analitik dengan rancangan cross sectional. Sampel serum petani yang terpapar pestisida diukur kadar kratinin dan ureum.

Hasil Penelitian : Rata-rata kadar kratinin yang tidak terpapar pestisida 0.6542 mg/dl, yang terpapar pestisida 0.8417 mg/dl dan  , sedangkan rata-rata   kadar ureum pada responden yang tidak terpapar pestisida adalah 23.000 mg/dl, yang terpapar pestisida 35.4583 mg/dl dengan nilai signifikan 0,000 (p<0,05)

Kesimpulan : Terdapat pengaruh paparan pestisida terhadap kadar kreatinin dan ureum pada petani di Desa Tanjung, Kabupaten Lombok Utara.
HUBUNGAN PENGETAHUAN DENGAN SIKAP KELUARGA PENGRAJIN GERABAH DALAM PENCEGAHAN PENYAKIT INFEKSI SALURAN PERNAFASAN AKUT (ISPA) DI WILAYAH KERJA PUSKESMAS BANYUMULEK
Authors: Eva Eva Marvia
Published: May 2023

ABSTRAK

 

Infeksi Saluran Pernafasan Akut merupakan penyakit saluran pernapasan atas atau bawah, biasanya menular, yang dapat menimbulkan berbagai spektrum penyakit yang berkisar dari penyakit tanpa gejala atau infeksi ringan sampai penyakit yang parah dan mematikan, tergantung pada patogen penyebabnya, faktor lingkungan, dan faktor pejamu. Penelitian ini bertujuan untuk mengetahuai hubungan pengetahuan dengan sikap keluarga pengrajin gerabah dalam pencegahan penyakit ISPA di wilayah kerja Puskesmas Banyumulek.

Desain kuantitatif dengan pendekatan cross sectional. Sedangkan sampel diambil dengan menggunakan simple random sampling. Populasi dalam penelitian ini sebanyak 154 Kepala keluarga. Sedangkan sampel sebanyak 59 kepala keluarga yang terdiri dari 112 responden. Pengumpulan data menggunakan kuesioner pengetahuan dan kuesioner sikapmenggunakan uji Spearman Rank dengan taraf kesalahan 5%.

Berdasarkan hasil penelitian didapatkan hasil distribusi umur berada di dewasa akhir sebanyak 36 responden (32,1%), jenis kelamin perempuan sebanyak 63 responden (56,2%), pekerjaan sebanyak sebagai pelajar sebanyak 30 responden (26,8%), pendidikan terakhir SMA sebanyak 35 responden (31,3%). Sedangkan distribusi yang memiliki pengetahuan baik 45 responden (40,2%), distribusi sikap positif sebanyak 101 responden (90,2%). Berdasarkan hasil uji statistik spearman Rank didapatkan nilai p=0,000. Ditetapkan apabila nilai p yang didapat  <0,05, maka dinyatakan Ho ditolak dan Ha diterima.

Terdapat hubungan pengetahuan dengan sikap keluarga pengrajin gerabah dalam pencegahan penyakit Infeksi Saluran Pernafasan Akut (ISPA)  di Wilayah kerja Puskesmas Banyumulek. Diharapkan dari pelayanan Kesehatan memberikan pendidikan menyeluruh ke keluarga tentang pencegahan penyakit Infeksi Saluran Pernafasan Akut (ISPA).
HUBUNGAN FAKTOR KESEHATAN FISIK DAN TIPE KEPRIBADIAN DENGAN KEMANDIRIAN LANSIA DALAM PEMENUHAN ACTIVITY DAILY LIVING DI PSLU MECI ANGI KOTA BIMA
Authors: Ageng Ageng Abdi Putra
Published: May 2023

Di Indonesia jumlah Lansia saat ini mencapai 21 juta jiwa dan diperkirakan di tahun 2030 bertambah menjadi dua kali lipat Sedangkan jumlah penduduk lansia di NTB dengan usia 60-69 tahun sebanyak 201.531 jiwa. Usia 70-79 tahun sebanyak 90.138 jiwa dan usia 80+ sebanyak 33.700 jiwa. Dengan total keseluruhan penduduk lansia di NTB sekitar 325.369 jiwa. Di PSLU Meci Angi Kota Bima jumlah Lansia sebanyak 50 orang dengan jumlah lansia wanita sebanyak 25 orang dan jumlah lansia pria sebanyak 25 orang. Dari 50 lansia tersebut terdapat 5 lansia berada di ruangan intensif yang mendapatkan perawatan khusus dari perawat.

Populasi dalam penelitian adalah Lansia di PSLU Meci Angi Kota Bima sebanyak 50 orang, dengan jumlah sample 44 responden didapatkan dengan tehnik purposive sampling. Instrument menggunakan kuesioner kesehatan fisik, tipe kepribadian dan kemandirian.

Hasil penelitian menunjukkan bahwa ada hubungan faktor kesehatan fisik dan tipe kepribadian dengan kemandirian lansia dalam pemenuhan Activitas Daily Living di PSLU Meci Angi Kota Bima tahun 2021. dibuktikan dari hasil uji Chi-Square Tests hubungan kesehatan fisik dengan kemandirian didapatkan  nilai p-value < ? (0,000<0,05), maka Ha diterima dan H0 ditolak. Sedangkan hubungan tipe kepribadian dengan kemandirian didapatkan nilai p-value < ? (0,016<0,05), maka Ha diterima dan H0 ditolak.

Kesimpulan :  ada hubungan faktor kesehatan fisik dan tipe kepribadian dengan kemandirian lansia dalam pemenuhan Activitas Daily Living di PSLU Meci Angi Kota Bima tahun 2021.
ETHNOPHARMACY SUKU ANAK DALAM OF BUNGKU VILLAGE, BAJUBANG DISTRICT, BATANGHARI REGENCY, JAMBI PROVINCE IN 2021
Authors: Pratiwi Puspa Dwi
Published: May 2023

Suku Anak Dalam (SAD), the one of ethnics in Indonesia precisely on Jambi Province still use various types of plants and animals part as medical substance. Traditional medicine among local ethnics has differences of each other. In addition, the depletion of forests as a source of life and modern culture make traditional medicine been forgotten. The aim of this study was determine the souce of natural products used by SAD for medical purposes. It was a descriptive study using purposive sampling and snow ball sampling to get as much data as possible about medicinal plants or animals used by Suku Anak Dalam, Bungku Village. The results showed that there were 17 plats and 4 animals used by SAD for medicine. The disease are often experienced by Suku Anak dalam are stomachache, dyspepsia, kidney desease, dengue, hyperlipidemia, vulnus, toothache, and ascariasis. The part of natural product frequently used include root, stem, leaves, and sap, which were commonly processed by boiling, mashing, eating, searing, sticking, and burning. Based on the results that has been done that were 17 plants and 4 animals from different genus and family used as traditional medicine with different part and processed.
Hubungan Kemampuan Mencari Informasi Terhadap Tingkat Pengetahuan Self-Care Pasien Diabetes Melitus Tipe-2 Di Puskesmas Martapura 1
Authors: Ifariani Putri Fidella , Syahrizal Ramadhan  , Esty Restiana Rusida
Published: May 2023

Diabetes melitus adalah penyakit yang ditandai dengan kadar glukosa darah yang melebihi normal akibat tubuh kekurangan insulin baik absolut maupun relatif. Pasien diabetes melitus umumnya memiliki pengetahuan yang kurang tentang penyakit mereka, menunjukkan kurang memadai dalam perawatan diri (self-care). Self-care menjadi sangat penting dalam pengobatan diabetes melitus. Pengetahuan self-care merupakan suatu hal yang sangat diperlukan pada penderita diabetes melitus untuk mengontrol glikemik yang memadai. Untuk itu diperlukannya perawatan diri yang baik, yakni dengan dukungan dari kemampuan literasi kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan kemampuan mencari informasi terhadap tingkat pengetahuan self-care pasien diabetes melitus tipe-2. Rancangan penelitian yang digunakan adalah deskriptif analitik dengan menggunakan desain penelitian korelatif dengan berdasarkan metode pendekatan secara cross sectional. Data dikumpulkan dari pasien diabetes melitus tipe-2 yang berobat ke Puskesmas Martapura 1 menggunakan kuesioner. Kuesioner yang digunakan adalah HLS-EU-Q16 dan kuesioner pengetahuan self-care. Analisa hubungan menggunakan analisis uji chi-square. Hasil penelitian menunjukkan hasil perolehan nilai p– value sig. sebesar 0,000 nilai tersebut dapat dinyatakan < 0,05, yang berarti bahwa H1 diterima. Maka dapat disimpulkan bahwa terdapat hubungan antara kemampuan mencari informasi terhadap pengetahuan self-care pasien diabetes melitus tipe-2 di Puskesmas Martapura 1.
Analisa Tingkat Kepatuhan Pasien Home Care dalam Minum Obat Anti Hipertensi
Authors: Suhada Adriyan , Halid Musparlin
Published: May 2023

Hypertension is often referred to as a hidden killer disease because this disease usually does not give specific symptoms to sufferers and is very dangerous. Compliance in taking hypertension medication is a major problem for patients so that many patients experience sudden attacks when their blood pressure rises. Providing home care with counseling is reported to provide patients with a better understanding of the disease and can improve the patient's quality of life. The purpose of this study was to determine the level of compliance of home care patients in taking anti-hypertensive drugs at Mitra Dasan Cermen Pharmacy, to determine the factors that influence the compliance of home care patients in taking anti-hypertensive drugs. The research method used was cross sectional using a compliance level questionnaire and a questionnaire of factors affecting the level of compliance, the data were analyzed by the spearman rank correlation test. The results showed that 57.6% of respondents had a moderate level of compliance 42.4% of respondents had a moderate level of compliance, 3 factors affecting the level of compliance that had a relationship, namely gender p = 0.001), education level (p = 0.000), family support (p = 0.001), 4 factors of compliance level that did not have a relationship, namely employment status (p = 0.189), duration of hypertension (p = 0.805), health insurance participation (p = 0.065).
EVALUATION OF ANTIBIOTIC USE IN PEDIATRIC TYPHOID FEVER IN THE INPATIENT INSTALLATION OF RSUD NORTH LOMBOK
Authors: Adriyan Suhada  , Tuhfatul Ulya  , Sri Rahmawati  , Musparlin Halid
Published: May 2023

The purpose of this study was to find out whether the use of antibiotics in typhoid fever patients at the inpatient installation of the North Lombok - Tanjung Hospital met the rationality requirements which included the right patient, the right dose, the right drug, and the right indication according to the medical service standards (SPM) of North Lombok Hospital - Tanjung in 2017. This research is a non-experimental study. The research was carried out at the North Lombok - Tanjung Hospital. The results showed that, according to inpatient medical record data available at the North Lombok - Tanjung Hospital in 2021, there were 14 cases of children diagnosed with typhoid fever. The results showed that the selection of the type of antibiotic used for the treatment of typhoid fever was chloramphenicol at 42.85%, then the antibiotics cefotaxime, cefixim, tiamfenicol and ceftriaxone each at 14.28%. After evaluating the use of antibiotics in pediatric patients with typhoid fever at Lombok Utara - Tanjung Hospital in 2021, the percentage value for using antibiotics with the right indication was 100%, the right drug was 85.71%, the right dose was 85.71%, and the right patient of 100%.
Primary Spinal Cord Haemorrhage during COVID-19 Illness: A Novel Addition to the Endless Spectrum of Neurological Manifestations?
Authors: Desai Mehul , Jaggi Sunila , Surya Nirmal
Published: May 2023

Since its discovery in December 2019 severe acute respiratory syndrome coronavirus-2 (SARS-COV2), coronavirus disease-19 (COVID-19) pandemic has opened up a pandora’s box and put the entire health-care industry globally under trial by fire. Neurological manifestations of it started becoming apparent in first few months and as of now we are still facing never-ending gamut of central nervous system (CNS) disorders related to SARS-COV-2 infection. Spinal cord involvement in COVID-19 although very well documented, overall remains uncommon. Here we present an interesting case of spinal cord hemorrhage in a patient with COVID-19 positive status, the first of its kind to our knowledge in this ever so expanding spectrum of nervous system manifestations of SARS-COV2.
A Case Report of Metformin Related Lactic Acidosis
Authors: Akbaş İlker , Akufuk Caner , Yılmaz Muhammet Mustafa , Kurt Atilla Eren , Coşkun Fatih
Published: May 2023

Metformin is an oral antidiabetic drug of the biguanide classused in type 2 diabetic patients with normal renal function. The mortality rate is high in cases of lactic acidos is developing in metformin intoxication. In the emergency department, metformin intoxication should be considered in the differential diagnosis of patients whouse metformin and have high anion gap metabolic acidosis (lactic acidosis). The most important and effective treatment with early diagnosis is correction of metabolic acidosis with hemodialysis or hemofiltration methods, bicarbonate treatment, adjustment of blood glucose level. Cardiovascular system support therapy significantly reduces morbidity/mortality. In this case report, we present the early diagnosis and successful treatment of a patient with lactic acidosis due to metformin intoxication.
Unaffiliated Voters and Crossover Voting in Semi-Closed Primaries: The Case of Rhode Island
Authors: Thornburg Matthew
Published: May 2023

A significant number of voters in Rhode Island engage in the costly practice of changing party registration after voting in primaries in order to maintain unaffiliated registration. I theorize that the semi-closed election laws of the state motivate this behavior by allowing unaffiliated voters to choose either the Democratic or Republican primary and engage in crossover voting. Voters who switch party registration post-primary routinely engage in crossover voting. In the state, these voters reside in municipalities where access to both party primaries is valuable.
A Conceptual Model For a Decentralized Central Bank Digital Currency
Authors: Rahman Abdurrahman Arum
Published: May 2023

This paper develops a conceptual model for a decentralized central bank digital currency (CBDC) controlled by many central banks. A decentralized CBDC could potentially explore the advantages of digital technologies more deeply than centralized ones by making macro-fundamental reconciliations between economies. Furthermore, this concept could also potentially provide international liquidity for all (member) countries in the world sustainably, align macro-fundamental or eliminate global imbalances, and makes the international monetary system naturally more stable. A decentralized CBDC is a new kind of CBDC. This paper focuses on discussing the conceptual model and theoretical framework of how this system works in providing international liquidity and making the system balanced and stable.
Cheiloscopy: A preliminary study of lip prints for gender determination
Authors: Gopu Naga Sai Anirudh , Malle Jyothi Nikhila , Lingineni Gayathri
Published: May 2023

Aims: The present study was conducted to assess gender identification and this can be used as a reliable tool in the identification of an individual at any judicial process.

Materials and Methods: This study comprised of 82 dental students (42 females and 40 males) with age ranging from 19 to 21 years. Lip prints were recorded with the help of a cellophane tape strip and analysed according to Suzuki and Tsuchihashi classification criteria.

Results:The mean age distribution among males was 20.07 ± 0.81 where as in females it was 19.78 ± 0.73. Distribution of different patterns in upper lip vertical patterns was very prominent when compared with reticular, branched and intersecting.Distribution of different patterns in lower lip branched patterns was very prominent when compared with reticular and verticals. Comparing between upper lip with lower lip pattern wise there was no statistically significant.Compared different patterns in relation with lower lip the values showing stastically significant (p≤0.05).

Conclusion: Lip prints or Cheiloscopy can be used an individual identification. The results obtained in our study do not show any evidence that cheiloscopy can be used as gender identification. This could be because of smaller sample size, we need larger sample to give consolidated evidence related with gender identification.

Key words: Lip prints, Cheiloscopy, Forensic odontology, gender, identification
Stability of Blood Parameters in Chronic Periodontitis Patients- A
Comparative Study
Authors: Sharma Raveena , Vandana Vandana , Kaur Supreet , Singh Sahib Tej , Goyal Pankaj
Published: May 2023

Introduction:Anemia of chronic disease is defined as anemia occurring in chronic infections, inflammatory conditions or neoplastic disorders that are not due to marrow deficiencies or other diseases, and occurring despite presence of adequate iron stores and vitamins.

Methods: A total of 40 patients were selected for the study. Participants were divided into two groups viz group A (test group; n=20) with moderate to severe periodontitis and group B (control group; n=20) with periodontally healthy subjects. The patients chosen for the study had at least 30% or more of teeth having greater than or equal to 4 mm probing depth. Clinical parameters like gingival index (GI), Sulcus Bleeding Index (SBI), plaque index (PI),probing pocket depth (PD) and clinical attachment levels (CAL) were recorded for all the patients and blood parameters (hemoglobin and red blood cell count) were determined from peripheralblood samples. The results were analyzed statistically.

Results: The mean values of hemoglobin (Hb) and red blood cell (RBC) count were significantly reduced in test group as compared to control group.
Conclusion: A positive relationship was observed between the blood parameters viz. Hb, RBC count, and the severity of the chronic periodontal disease. Like other chronic conditions, periodontitis can tend towards anemia showing their association.

Keywords: Anemia, Chronic Periodontitis, Hemoglobin (Hb), Red Blood Cell Count (RBC Count).
Knowledge and Practices for Peri-Implantitis and Peri-Mucositis amongst dental practitioners: A Questionnaire Based Cross-Sectional study
Authors: Rodrigues Silvia , Kashid Rhea , Mitra Dipika , Khobragade Bela , Surve Neha
Published: May 2023

Background: Placement of dental implants is one of the most preferred methods of rehabilitation. Just as the periodontal tissue is essential for the stability of the dentition, healthy peri-implant tissue is essential for long-term stability of the dental implant.
Objective: To assess the knowledge and Awareness of Peri-Implantitis and Peri-Mucositis amongst dental practitioners

Methodology: 370 Qualified dental professionals registered with Dental Council of India who were willing to participate in the study and gave written informed consent. They were segregated on the basis of years of clinical practice and speciality. A pre-validated online questionnaire comprising of 27 questions was created using google forms and circulated among dentists with the consent form. A completely filled questionnaire was submitted online only to the investigator. Chi-square test of proportion and association was used. Mean and standard deviation scores were derived.

Results: Knowledge and awareness about Peri-Implantitis and Peri-Mucositis below average amongst dental practitioners but satisfactory amongst periodontists.

Conclusion: Workshops and CDE programs should be organised to increase knowledge and awareness about peri-implantitis and peri-mucositis since both are integral parts of Dental Implantology.

Key Words: Peri-Implantitis, Peri-Mucositis, Peri-Implant disease
Comparative Evaluation of Shear Bond Strength Of Various Core Build – up Materials In Maxillary Anterior Teeth - An In-Vitro Study
Authors: Prabakaran Pavithra , C H Laxmi Priya , B S Annapoorna
Published: May 2023

Need for the study: Incisors are commonly damaged by caries or trauma. The major portion of the crown part of a damaged anterior tooth could be restored with a core build-up material which not only reinstate aesthetics but also withstand an array of forces in the oral cavity.

Aim: To evaluate the Shear Bond Strength(SBS) of Zirconomer, Resin Modified Glass Ionomer cement(RMGIC), Microhybrid Composite and Nanocomposite as core build-up materials in maxillary anterior teeth.

Methodology: 48 extracted intact human maxillary central incisors were collected and divided into four groups.Anatomic crown was trimmed upto fifty percent which involved the enamel and partly the dentin of each tooth. The experimental teeth were mounted in chemical cure acrylic resin and restored with Zirconomer, RMGIC, Microhybrid Composite and Nanocomposites. The samples were subjected to Shear Bond Strength(SBS) analysis using a universal testing machine (UTM).

Results: Composites exhibited better mechanical properties than Glass Ionomer Cements. Nanocomposites had the highest Shear Bond Strength followed by microhybrid composites but there was no statistical significance.

Conclusions: Nanocomposite possess better mechanical properties and also offers superior esthetics due to its supercilious polishability, proving to be the ideal core build-up material for maxillary anterior teeth.

Key-words:Core build up- Composite-Glass Ionomer Cements-Shear Bond Strength
Type 1 secretion system and effectors in Rickettsiales
Authors: Bui Duc-Cuong , Luo Tian , McBride Jere W.
Published: May 2023

Obligate intracellular bacteria in the order Rickettsiales are transmitted by arthropod vectors and cause life-threatening infections in humans and animals. While both type 1 and type 4 secretion systems (T1SS and T4SS) have been identified in this group, the most extensive studies of Rickettsiales T1SS and associated effectors have been performed in Ehrlichia. These studies have uncovered important roles for the T1SS effectors in pathobiology and immunity. To evade innate immune responses and promote intracellular survival, Ehrlichia and other related obligate pathogens secrete multiple T1SS effectors which interact with a diverse network of host targets associated with essential cellular processes. T1SS effectors have multiple functional activities during infection including acting as nucleomodulins and ligand mimetics that activate evolutionarily conserved cellular signaling pathways. In Ehrlichia, an array of newly defined major immunoreactive proteins have been identified that are predicted as T1SS substrates and have conformation-dependent antibody epitopes. These findings highlight the underappreciated and largely uncharacterized roles of T1SS effector proteins in pathobiology and immunity. This review summarizes current knowledge regarding roles of T1SS effectors in Rickettsiales members during infection and explores newly identified immunoreactive proteins as potential T1SS substrates and targets of a protective host immune response.
First in human neochordae retensioning for recurrence of mitral regurgitation after neochord procedure
Authors: Fiocco Alessandro , Pittarello Demetrio , D’Onofrio Augusto , Mastro Florinda , Gerosa Gino , Colli Andrea
Published: May 2023

The Neochord procedure is a viable option to treat degenerative mitral valve regurgitation in selected patients. Left ventricle reverse remodeling can cause neochord-relative elongation and reprolapse of the treated leaflet, leading to failure. We present a clinical case of extensive ventricle reverse remodeling after neochord implantation and the first-in-man off-pump surgical retensioning of the previously implanted artificial chords.
Evaluating gifted students’ perceptions of the characteristics of their effective teachers
Authors: Aboud Yusra Zaki
Published: May 2023

Due to the special needs of gifted students, it is crucial that their teachers are carefully selected in order to give gifted students the greatest educational experience. The study involved 120 teachers from Saudi Arabia, Bahrain, and the United Arab Emirates along with 300 gifted students, both males (n = 144) and females (n = 156). Teachers of gifted students involved in the study were asked to complete the Preferred Teacher Characteristics Scale (PICS); additionally, teachers filled out a background questionnaire. While gifted students responded to three open-ended questions, The findings corroborated the idea that gifted students perform better in an environment where their teachers’ personalities are evident. This finding was in line with the preferences of teachers as measured by the PCIS scale, which revealed that students tended to value teachers more for their personal characteristics than for their professional ones. Many personal characteristics were highly regarded by the gifted students, who in this study believed they contributed to a teacher’s effectiveness. Personal integrity, tolerance, tenderness, friendliness, a sense of humor, and an openness to new experiences were among these characteristics.
Evaluating barriers and strategies to green energy innovations for sustainable development: developing resilient energy systems
Authors: Wang Donglin , Li Jie , Liu Yuhang
Published: May 2023

Achieving sustainable development and reducing climate change require a shift to green energy sources. Yet, switching to green energy sources necessitates substantial research and development, as well as regulatory and policy adjustments. Additionally, a number of obstacles are impeding the development of green energy innovation. This study identified several key barriers and sub-barriers that obstruct the development of green energy innovation. Thus, this study identified multiple strategies to overcome those barriers. Therefore, this study uses the fuzzy Analytical Hierarchy Process (AHP) and fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) methods to assess and rank the barriers and strategies to building resilient energy systems in China. First, the fuzzy AHP method identifies the four barriers and sixteen sub-barriers, while the fuzzy TOPSIS method classifies six strategies for the green energy innovation system in China. According to AHP results, funding and policy constraints are the most crucial barriers to green energy innovation. The fuzzy TOPSIS findings show that providing incentives for green energy investment and strengthening policy implementation and enforcement are the most significant strategies for overcoming the barriers to green energy projects.
Data driven model discovery and interpretation for CAR T-cell killing using sparse identification and latent variables
Authors: Brummer Alexander B. , Xella Agata , Woodall Ryan , Adhikarla Vikram , Cho Heyrim , Gutova Margarita , Brown Christine E. , Rockne Russell C.
Published: May 2023

In the development of cell-based cancer therapies, quantitative mathematical models of cellular interactions are instrumental in understanding treatment efficacy. Efforts to validate and interpret mathematical models of cancer cell growth and death hinge first on proposing a precise mathematical model, then analyzing experimental data in the context of the chosen model. In this work, we present the first application of the sparse identification of non-linear dynamics (SINDy) algorithm to a real biological system in order discover cell-cell interaction dynamics in in vitro experimental data, using chimeric antigen receptor (CAR) T-cells and patient-derived glioblastoma cells. By combining the techniques of latent variable analysis and SINDy, we infer key aspects of the interaction dynamics of CAR T-cell populations and cancer. Importantly, we show how the model terms can be interpreted biologically in relation to different CAR T-cell functional responses, single or double CAR T-cell-cancer cell binding models, and density-dependent growth dynamics in either of the CAR T-cell or cancer cell populations. We show how this data-driven model-discovery based approach provides unique insight into CAR T-cell dynamics when compared to an established model-first approach. These results demonstrate the potential for SINDy to improve the implementation and efficacy of CAR T-cell therapy in the clinic through an improved understanding of CAR T-cell dynamics.
Regulatory roles of SP-A and exosomes in pneumonia-induced acute lung and kidney injuries
Authors: Chen Xinghua , Guo Junping , Mahmoud Salma , Vanga Gautam , Liu Tianyi , Xu Wanwen , Xiong Yunhe , Xiong Weichuan , Abdel-Razek Osama , Wang Guirong
Published: May 2023

Introduction

Pneumonia-induced sepsis can cause multiple organ dysfunction including acute lung and kidney injury (ALI and AKI). Surfactant protein A (SP-A), a critical innate immune molecule, is expressed in the lung and kidney. Extracellular vesicles like exosomes are involved in the processes of pathophysiology. Here we tested one hypothesis that SP-A regulates pneumonia-induced AKI through the modulation of exosomes and cell death.

Methods

Wild-type (WT), SP-A knockout (KO), and humanized SP-A transgenic (hTG, lung-specific SP-A expression) mice were used in this study.

Results

After intratracheal infection with Pseudomonas aeruginosa, KO mice showed increased mortality, higher injury scores, more severe inflammation in the lung and kidney, and increased serum TNF-α, IL-1β, and IL-6 levels compared to WT and hTG mice. Infected hTG mice exhibited similar lung injury but more severe kidney injury than infected WT mice. Increased renal tubular apoptosis and pyroptosis in the kidney of KO mice were found when compared with WT and hTG mice. We found that serum exosomes from septic mice cause ALI and AKI through mediating apoptosis and proptosis when mice were injected intravenously. Furthermore, primary proximal tubular epithelial cells isolated from KO mice showed more sensitivity than those from WT mice after exposure to septic serum exosomes.

Discussion

Collectively, SP-A attenuates pneumonia-induced ALI and AKI by regulating inflammation, apoptosis and pyroptosis; serum exosomes are important mediators in the pathogenesis of AKI.
Broad-spectrum anti-HIV activity and high drug resistance barrier of lipopeptide HIV fusion inhibitor LP-19
Authors: He Lin , Wang Chen , Zhang Yuanyuan , Chong Huihui , Hu Xiaoyan , Li Dan , Xing Hui , He Yuxian , Shao Yiming , Hong Kunxue , Ma Liying
Published: May 2023

Lipopeptide-19, a HIV fusion inhibitor (LP-19), has showed potent anti-HIV activity. However, there is still limited information of the antiviral activity against different subtype clinical isolates and the drug resistance barrier of LP-19. Therefore, 47 HIV clinical isolates were selected for this study. The viral features were identified, in which 43 strains are CCR5 tropisms, and 4 strains are CCR5/CXCR4 tropisms, and there are 6 subtype B’, 15 CRF01_AE, 14 CRF07_BC, 2 CRF08_BC and 10 URF strains. These 47 viruses were used to detected and analyze the inhibitory activities of LP-19. The results showed that the average 50% inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) of LP-19 were 0.50 nM and 1.88 nM, respectively. The average IC50 of LP-19 to B’, CRF01_AE, CRF07_BC, CRF08_BC, and URF strains was 0.76 nM, 0.29 nM, 0.38 nM, 0.85 nM, and 0.44 nM, respectively. C34 and Enfuvirtide (T-20), two fusion inhibitors, were compared on the corresponding strains simultaneously. The antiviral activity of LP-19 was 16.7-fold and 86-fold higher than that of C34 and T-20. The antiviral activity of LP-19, C34, and T-20 were further detected and showed IC50 was 0.15 nM, 1.02 nM, and 66.19 nM, respectively. IC50 of LP-19 was about 7-fold and 441-fold higher compared to C34 and T-20 against HIV-1 NL4-3 strains. NL4-3 strains were exposed to increasing concentrations of LP-19 and C34 in MT-2 cell culture. The culture virus was sequenced and analyzed. The results showed that A243V mutation site identified at weeks 28, 32, 38, and 39 of the cell culture in the gp41 CP (cytoplasmic domain) region. NL4-3/A243V viruses containing A243V mutation were constructed. Comparing the antiviral activities of LP-19 against HIV NL4-3 to HIV strains (only 1.3-fold), HIV did not show drug resistance when LP-19 reached 512-fold of the initial concentration under the drug pressure for 39 weeks. This study suggests that LP-19 has broad-spectrum anti-HIV activity, and high drug resistance barrier.
Fatigue failure and energy evolution of double-stepped fissures contained marble subjected to multilevel cyclic loads: a lab-scale testing
Authors: Wang Di , Luo Zhixiong , Xia Hongbo , Gao Shangqing , Li Peiliang , Li Juzhou , Wang Yu
Published: May 2023

The instability of rock mass induced by the deterioration and failure of rock bridge is often encountered in hard rock engineering. Under engineering disturbance, a steep and gentle stepped sliding surface is prone to forming along the rock bridges between the intermittent rock joints, which directly controls the rock mass instability modes. In order to reveal the influence of fissure angle on the fatigue deterioration and energy evolution mechanism of stepped double-flawed hard rock, the multilevel cyclic loading mechanical test were carried out on flawed marble samples with fissure angle of 10°, 30°, 50°, and 70° angles. The testing shows that rock strength, fatigue lifetime, peak strain and dissipated energy increase with increasing fissure angle and the increase rate of them becomes sharply in the high cyclic level. In addition, the increase of dissipated energy accelerates with the increase of cyclic loading level, and shows a sudden increase trend in the last cyclic loading stage. When the joint fissure angle is 10°, the dissipated energy is the smallest and the dissipated energy is the largest at 70°. Moreover, a damage evolution model based on dissipated energy is established to describe the characteristics of damage accumulation. The model is in good agreement with the experimental data and reflects the nonlinear characteristics of damage accumulation.