bluuebunny/crossref_metadata_2025 huggingface dataset:
Evagations Diagrams in Medieval Computus
Authors: Pedro Celeste Maria Lourenço da Silva de Oliveira
Published: July 2024

Evagations diagrams are visualisations of patterns of cyclical movements of celestial objects (that could be measured by observation and calculated using different methods, but which were difficult to grasp purely from texts), that developed as a medieval visual tradition. Its design was intended to assist the reader in making sense of complex information (presented in circulating manuscripts) through an imagetic translation of those phenomena – that are otherwise only visible through long-term sky observations. Their frequent presence in computus turned them into graphical receptacles (or templates) for different concepts related to the paths of planets, such as elongations, altitudes, latitudes and longitudes, which were key to understanding how the world worked, and to determining the usefulness of that knowledge.Starting with manuscript Bern Cod. 347, a composite manuscript produced in the second half of the ninth century in the region of Auxerre, this article will provide an overview on the transmission of diagrams of latitudes (planetary wanderings in relation to the ecliptic of the sun through the course of the zodiac) in manuscripts assembled and copied mainly for Benedictine schools, in the Carolingian and post-Carolingian periods; exploring them as pictorial representations of an established visual concept, made up of a mixture of real and imaginary data, and will inquire about the ways in which these compositions were used to convey cosmographical knowledge.
El pesimismo de Schopenhauer y la influencia del Periphyseon
Authors: Ruiz Callejón Encarnación
Published: July 2024

This paper analyses the influence of Scotus Erigena’s Periphyseon in relation to Arthur Schopen-hauer’s modulation of pessimism. The first part deals with his interpretation of the medieval period and direct references to Erigena. In the second and third parts, why Erigena’ work should be conside-red as an important key to understand Schopenhauer’s pessimism.
Barhebraeus on the Internal Senses and Animal Self-Awareness. Some Notes on Furlani and Bakoš
Authors: Schmitt Jens Ole
Published: July 2024

The Avicennan internal senses are also dealt with by Barhebraeus (1226-1286 CE), the famous Syr-ian Orthodox polymath of the Syriac Renaissance. Their treatment in the course of their occurrences in different works will be looked into as well as a shift in terminology. Also, Barhebraeus’s stance on whether animals have a share in rationality like humans or have at least a certain self-awareness and its connection with these internal senses shall be briefly considered. Possible Arabic influences besides Avicenna will also be taken note of. Through this, the paper aims at adding to Furlani’s and Bakoš’s initial works on Barhebraeus’s psychology.
Millennials and Z’s Intention to Leave: Leadership, Work Environment, Workload, Flexible Work, Job Satisfaction
Authors: Pertiwi Ni Made Marlynia Sukma ,   Master of Management Postgraduate Program, Pendidikan Nasional University, Indonesia, Prena Gine Das ,   Master of Management Postgraduate Program, Pendidikan Nasional University, Indonesia
Published: July 2024

Intention to leave from millennial and z generation employees in the company is quite high. This will cause problems for the company's sustainability in the future. This research was conducted in the retail industry of WHSmith Indonesia which is spread across 3 regions of Bali, Jakarta and Makassar, which aims to investigate the factors that influence employee intention to leave, there are transformational leadership, work environment, workload, and flexible work arrangement using job satisfaction as a mediating variable. In this study using 168 millennial and z generation employees in WHSmith who participated in filling out questionnaires using SEM-PLS and uses a millennial and z generation multigroup test with the SmartPLS 4 analysis tool. The results showed that transformational leadership and work environment had no effect on intention to leave, workload had a positive effect on intention to leave, meanwhile flexible work arrangement and job satisfaction had a negative effect on intention to leave, transformational leadership, work environment, and flexible work arrangement have a positive effect on job satisfaction, meanwhile workload has a negative effect on job satisfaction, transformational leadership, work environment, and flexible work arrangement have a negative effect on intention to leave through job satisfaction as a mediating variable, meanwhile workload has a positive effect on intention to leave through job satisfaction as a mediating variable among WHSmith employees. The results of multigroup analysis are also discussed in this study. This research provide insight for the WHSmith company regarding the causes of intention to leave in the millennials and z generations, so the company can have loyal employees in the future.
Banking on Belief: Investigating the Influence of Religiosity on Sharia Banking Adoption
Authors: Fattah Vitayanti ,   Tadulako University, Palu, Indonesia, Bachri Syamsul , Sutomo Maskuri , Farid Farid , Farid Erwan Sastrawan ,   Tadulako University, Palu, Indonesia,   Tadulako University, Palu, Indonesia,   Tadulako University, Palu, Indonesia,   Tadulako University, Palu, Indonesia
Published: July 2024

One of the financial institutions currently developing in Indonesia is sharia banking, but previous research states that the majority of people still use conventional banking products. This is because conventional banks have various products, are more diverse, and have advantages over sharia banks. Therefore, this research aims to identify how religiosity and perceptions can influence people's decisions to use sharia banking services. The type of research conducted is quantitative research. Quantitative research is the type of research conducted. The population consists of 1350 traders located in Manonda Market and Masomba Market in Palu City. Simple Random Sampling is the sampling technique used. In this research, there are 180 respondents whose data will be used to test the hypotheses. The research takes place in the traditional markets of Masomba and Manonda in Palu City, and the data collection was conducted in the year 2023. The data that will be used to test the hypothesis in this research is 180 respondents from questionnaires distributed directly to respondents. The research results show that religiosity can influence people's perceptions regarding Islamic banks; apart from that, perceptions are also found to influence consumer decisions when using sharia banking products. Furthermore, perception can be a good mediator between religiosity and consumer decisions, but in this research, it was found that religiosity cannot influence people's decisions to use sharia banking. The implications of this research are important for academics by opening opportunities for further research regarding the complexity of the relationship between religiosity, perceptions and customer decisions in Islamic banking. For Islamic banking practitioners, these results emphasize the importance of understanding the role of perception in increasing the acceptance and use of Islamic services.
The Effects of Leverage, Firm Size, and Market Value on Financial Performance in Food and Beverage Manufacturing Firms
Authors: Estiasih Soffia Pudji ,   Universitas PGRI Adi Buana Surabaya, Indonesia, Suhardiyah Martha , Suharyanto Suharyanto , Putra Andhika Cahyono , Widhayani Puri Setioningtyas ,   Universitas PGRI Adi Buana Surabaya, Indonesia,   Universitas PGRI Adi Buana Surabaya, Indonesia,   Universitas Muhammadiyah Surabaya, Indonesia,   The Hungarian University of Agriculture and Life Sciences Budapest Hungaria, Hungary
Published: July 2024

Financial performance is an important phenomenon for measuring organizational success. This research aims to determine and analyze the influence of leverage, company size, and market value on financial performance. The research methods used are explanatory; the population used is food and beverage Manufacturing companies in the Food and Beverage sector listed on the Indonesia Stock Exchange for the 2017-2019 period are used to determine the number of samples in this study. From 31 December 2017 to 31 December 2019. The sampling technique used is a purposive sampling method and there are 12 companies published audited financial reports and reported them completely and consistently using the purposive sampling technique with criteria. The Source of data used is secondary data with a time series type of data. The hypothesis is tested using Partial Least Square (PLS) analysis with Smart PLS 3.0 software. The results show that Leverage has a significant effect on Financial Performance. At the same time, Firm Size had no significant effects on Financial Performance and Market Value had no significant effects on Financial Performance. This research implies that food and beverage companies need to develop financial strategies to improve their financial performance by increasing their leverage.
CONTENT AREA LITERACY APPROACH FOR TEACHERS AS AN EFFORTS TO IMPROVE STUDENT'S CRITICAL AND CREATIVE LITERATURE ABILITY
Authors: Andarwulan Trisna , Damayanti Galieh , Setyaningsih Emi , Yuana Ambayu Sofya
Published: July 2024

Quality education is a major need in the era of increasingly competitive global competition. One of the government's efforts to make quality education is to increase literacy culture. The content area literacy approach (content area literacy) is the basis for implementing community service activities. Content area literacy is the ability to use reading and writing skills to study subject matter in a discipline; teach skills that “beginners” might use to understand disciplinary texts; a set of learning skills that can be generalized across content areas. Area literacy (content area literacy) requires content area teachers to develop literacy skills for their discipline as well as be confident in their ability to teach and develop content as they use these skills. This mentoring is relevant for all science content area teachers in schools, school administrators, literacy and instructional coaches, school counselors, and others interested in teaching and learning. This mentoring activity, which is a form of PMPK lecturer dedication, was carried out at SD Negeri 3 Duvet, Malang. This activity is for teachers and education personnel in the school.
GRAPHIC DESIGN IN THE CREATIVITY DEVELOPMENT OF STUDENTS AT THE TAHFIDZ AL-QURAN ISLAMIC BOARDING SCHOOL "OEMAH AL-QURAN" MERJOSARI LOWOKWARU MALANG
Authors: Hasibuan Albar , Chanifah Nur , Fitrahayunitisna  , Hambali Muhammad , Muhammad Noor Aditia
Published: July 2024

As an educational institution, Islamic boarding schools are required to carry out significant acceleration and transformation. If in the past the scope of output was limited to the religious dimension, now pesantren graduates are expected to be able to contribute a lot in various aspects of people's lives. The development of applications in the field of information technology has a major impact in various fields of life, including in the creative industries such as printing, digital image processing and graphic design. This requires us to provide training to students so that they can follow developments and be able to use it for preparation after they graduate. Training on the use of these applications is important to equip students' creativity so that later when they leave the boarding school, they can develop these skills to be more independent. Even these skills can also equip students for entrepreneurship, so they can support their economy. Based on this reality, the MPK Center Community Service Team initiated to assist Islamic boarding schools in developing students' creativity through graphic design training. This is because the human resources owned by Islamic boarding schools in the field of graphic design are minimal or even non-existent. With the graphic design training, it is hoped that it can help pesantren in equipping students with skills so that their creativity is formed.
MITIGATION IN THE SEXUAL VIOLENCE PONDOK PESANTREN SINGOSARI ISHLAHIYAH CAMPAIGNS SOCIAL MEDIA-BASED DIGITAL LITERACY
Authors: Fiaji Noveria Anggraeni
Published: July 2024

Al Ishlahiyah Islamic Boarding School is the oldest Islamic boarding school in Singosari with a curriculum that is getting better every year. However, there is no mention of sexual education in the curriculum, even though cases of sexual violence don’t rule out the possibility of occurring in Islamic boarding schools. Based on the description of the situation analysis, the problems faced by partners are 1) a Low understanding of students on acts of sexual violence that may have been experienced by students, and 2) there has been no sexual violence mitigation training in Islamic boarding schools and on campuses. Based on the problems, several solutions were formulated namely 1) preparing digital literacy designs for sexual mitigation of students, 2) increasing the competence (cognitive, affective, psychomotor) of students in mitigating sexual violence, and 3) evaluating sexual violence mitigation training through digital literacy. In according with the PBL principle, the digital literacy training syllabus is prepared in the stage of understanding cases of sexual violence that have occurred at the boarding school, 2) the stage of training in making public texts with the theme of sexual violence through digital literacy, 3) the stage of training content creation in the form of public texts as sexual violence mitigation education, and 4) the training stage for disseminating the results of public texts through campaigns on social media. From these activities, it can be seen that 1)an increase in participant's understanding regarding sexual violence, responsive pathways for handling sexual violence, prevention of sexual violence, and anti-sexual violence campaigns in Islamic boarding schools, 2) Islamic Boarding Schools established a crisis center Islamic Boarding school as a form of advocacy and partisanship of Islamic boarding School on prevention and treatment sexual violence in Islamic boarding schools, and 3) there is an agreement (MoU) to develop an anti-sexual violence discourse with UPT PKM UB.
MECHANISM IMPLEMENTATION OF CORPORATE SOCIAL RESPONSIBILITY BY THE MINING COMPANY
Authors: Dewantara Reka
Published: July 2024

The ratification of UUPT No. 40 of 2007 is an urgent need for entrepreneurs as entrepreneurs and the state as a regulator of commercial life. This is because the GmbH law that was in effect before is no longer relevant to the development of business life. In general, there have been several significant substantive changes to the Limited Liability Company Law, one of which is the Corporate Social Responsibility (CSR) or Law no. 40 of 2007 which expresses the notion of social and environmental responsibility. The method used in this research is empirical juridical by using descriptive qualitative data analysis method. The results of this community service show that improving the company's performance at the KPC mine can be increased by carrying out its CSR program, therefore the company and the CSR team within it must approach the local community who are located around the mining area more frequently. The approach to the community is carried out by cooperating with academics, this aims to identify the economic, social, environmental, and cultural backgrounds of the community, then ensures the achievement of the expected impact with limited resources the company also holds various pieces of training for the community, this approach is taken to prevent community disputes when participating with the company.
SOSIALISASI TENTANG BAHAYA PERILAKU BULLYING BERDASARKAN PERSPEKTIF UNDANG-UNDANG PERLINDUNGAN ANAK
Authors: Sulastri Sulastri , Rustandi Roni
Published: July 2024

The problem of bullying (bullying) against school-age children today is increasingly felt to be troubling the community, especially at school. Not only in urban areas bullying also arises and develops in rural areas, this is due to social changes that occur in the community. Social change is influenced by massive globalization where the barriers between all levels of the world no longer exist. Bullying behavior is behavior that has a negative impact on several aspects of life (physical, psychological, and social individuals), especially adolescents. This is a highlight for education stakeholders to participate in preventing bullying cases in schools. We as a team of service lecturers are also touched to help prevent bullying cases in schools by providing counseling to students to provide an understanding that these acts are regulated in the law and should not be done. The target to be achieved in this community service activity is to achieve increased understanding for students related to matters related to prundungan. The result obtained from this service activity is that students know that bullying activities are regulated by law number 35 of 2014 concerning amendments to law number 23 of 2002 concerning child protection.
PENGARUH MIGRASI TERHADAP KESEJAHTERAAN MASYARAKAT DI INDONESIA
Authors: Saputra Nur Cahya Eko , Pierewan Adi Cilik
Published: July 2024

Penelitian bertujuan untuk mendapatkan hasil analisis yang menjelaskan bagaimana migrasi berpengaruh terhadap kesejahteraan masyarakat di Indonesia. Penelitian ini menggunakan data sekunder yang bersumber dari Indonesia Family Life Survey (IFLS) edisi ke-5. Penelitian ini menggunakan metode kuantitatif dengan teknik analisis linier berganda dengan bantuan software analisis statistik R Studio versi 3.5.2. Responden yang digunakan pada penelitian ini berjumlah 3959 orang yang berasal dari 13 provinsi di Indonesia. Hasil penelitian ini menunjukkan bahwa dua dari tiga variabel migrasi menunjukkan hubungan yang tidak signifikan terhadap variabel kesejahteraan. Sehingga dapat dipahami bahwa migrasi tidak signifikan dalam memprediksi kesejahteraan masyarakat di Indonesia. Hal ini dibuktikan dengan skor estimasi status migrasi terhadap variabel kesejahteraan sebesar -0.17565 pada kepuasan hidup, skor estimasi sebesar -0.222443. pada kondisi kehidupan rumah tangga, dan skor estimasi sebesar -0.208113. pada kebahagiaan. Temuan ini menunjukkan bahwa migrasi yang dilakukan oleh individu atau kelompok tidak serta merta dapat meningkatkan kesejahteraan. Skor estimasi tujuan migrasi terhadap variabel kesejahteraan sebesar 0.08649** pada kepuasan hidup, skor estimasi sebesar 0.041349* pada kondisi kehidupan rumah tangga, dan skor estimasi sebesar 0.024329 pada kebahagiaan. Temuan ini menunjukkan bahwa masih banyak persepsi masyarakat menganggap bermigrasi ke kota merupakan pilihan untuk menjadi lebih sejahtera. Skor estimasi alasan migrasi terhadap variabel kesejahteraan sebesar -0.07070 pada kepuasan hidup, skor estimasi sebesar 0.007768 pada kondisi kehidupan rumah tangga, dan skor estimasi sebesar 0.017435 pada kebahagiaan. Hasil temuan ini menunjukkan bahwa alasan migrasi seperti alasan mencari kerja di lokasi tujuan tidak serta merta dapat membuat para migran menjadi lebih sejahtera.
FAKTOR-FAKTOR YANG MELATARBELAKANGI PEREMPUAN SEBAGAI PENGEMUDI OJEK ONLINE DI YOGYAKARTA
Authors: Fanani Muhamad Hasan , Hidayah Nur
Published: July 2024

Ojek online merupakan jasa transportasi yang mampu memberikan lapangan pekerjaan bagi masyrakat, tak terkecuali bagi perempuan membuat bertambahnya alternatif pilihan bagi perempuan dalam bekerja. Sistem kerja yang mengandalkan fleksibilitas yang tinggi membuat pekerjaan ini sangat menjadi satu pilihan yang rasional bagi mereka dalam bekerja. Tujuan penelitian ini adalah untuk mengetahui faktor yang melatarbelakangi perempuan bekerja sebagai pengemudi ojek online di Yogyakarta. Metode penelitian yang digunakan adalah deskriptif kualitatif. Populasi dalam penelitian ini adalah pengemudi ojek online baik perempuan maupun laki-laki dan dari pihak keluarga perempuan dan pihak pengguna ojek online di Yogyakarta dengan teknik sampling purposive sampling. Teknik pengumpulan data yang digunakan adalah observasi dan wawancara. Teknik analisis yang digunakan yaitu teknik analisis interaktif yang dikemukakan oleh Miles dan Hubberman dan menggunakan analisa teori pilihan rasional James Coleman bahwa tindakan perseorangan mengarah kepada suatu tujuan dan tujuan itu ditentukan oleh  nilai atau  pilihan. Hasil penelitian ini menyatakan bahwa pilihan rasional dalam aktivitas aktor yaitu perempuan yang memilih bekerja sebagai pengemudi ojek online untuk mencapai tujuannya adalah karena faktor memenuhi kebutuhan, waktu bekerja fleksibel, tidak ada target dalam bekerja, pendapatan, dan relasi jaringan pekerjaan. Didalam hasil analisis teori pilihan rasional terdapat aspek aktor, sumber daya, nilai, dan lembaga sosial yang mempengaruhi mereka dalam mencapai tujuan yang merka inginkan.
Transformasi Sosio-Religius Masyarakat Pedesaan (studi pergeseran pemaknaan slametan di Padukuhan Sawo, Sumberharjo, Prambanan, Sleman, Daerah Istimewa Yogyakarta)
Authors: Priyono Fanin Ari , Pinasti V. Indah Sri
Published: July 2024

Slametan sebagai sebuah sebuah warisan budaya hasil akulturasi kepercayaan jawa dengan agamaislam yang telah dilaksanakan turun temurun oleh masyarakat padukuhan sawo saat inimenghadapi pola-pola perubahan, berkaitan dengan perkembangan sosial dan religiusitasmasyarakat sebagai akibat dari modernisasi dan keterbukaan yang terjadi pada berbagai bidang.Penelitian ini menggunakan pendekatan kualitatif, dijabarkan secara deskriptif dengan sumber datayang terdiri dari masyarakat padukuhan Sawo yang memiliki relevansi serta pengetahuanmengenai slametan. Teknik pengumpulan data dalam penelitian ini adalah observasi, wawancaradan dokumentasi. Teknik sampling yang digunakan adalah purposive sampling. Adapun validitasdata yang digunakan adalah trianggulasi teknik dan sumber dan analisis data menggunakan analisisinteraktif Milles dan Hubberman. Hasil penelitian menunjukkan adanya pergeseran makna padapelaksanaan slametan dimana masyarakat tidak lagi sepenuhnya memaknai slametan sebagaisebuah bentuk ritus kepercayaan jawa-islam yang dalam pelaksanaannya sarat akan aturan-aturanadat yang ketat. Masyarakat saat ini memaknai slametan secara sederhana yaitu sebagai upayaberdoa secara bersama-sama untuk memohon kepada Allah SWT agar tidak terdapat halanganpada jalannya hajatan yang mereka laksanakan dan segala pengharapan mereka terkabul.Pergeseran pemaknaan pada slametan ini disebabkan oleh dua faktor utama yaitu faktorkepercayaan yang dipengaruhi oleh dinamika yang terjadi pada dinamika agama islamkepercayaan kejawen. Sementara faktor kedua adalah faktor sosial yang berkaitan denganperkembangan sosial-teknologi yang terjadi sebagai dampak interaksi dan modernisasi yangterjadi dalam masyarakat. Hasil dari dinamika yang terjadi di masyarakat ini adalah bentukpergeseran pemaknaan pada slametan dengan pemaknaan baru dimana penggunaan adat becorakkejawen ditinggalkan dengan berbagai alasan antara lain boros, rumit, serta bertentangan denganagama Islam. Disisi lain, juga muncul pemaknaan baru slametan sebagai bentuk budaya jawa yangdapat dikomersilkan dengan label wisata budaya, pada pemaknaan ini penggunaan unsur-unsuradat bercorak kejawen digunakan kembali namun dengan pemaknaan baru yang sama sekaliberbeda dengan pemaknaan yang sebelumnya ada di masyarakat.  Kata Kunci : Slametan, Sosial, Religiusitas, Pergeseran makna
PENGARUH PERTUMBUHAN PENJUALAN, KEPEMILIKAN MANAJERIAL, DAN KEPEMILIKAN SAHAM PUBLIK TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY
Authors: Novitasari Dwi
Published: July 2024

Dengan adanya berbagai kegiatan bisnis yang dijalankan oleh perusahaan untuk memenuhi kebutuhan barang dan jasa masyarakat, perlu diperhatikan dampak sosial dan lingkungan dari kegiatan operasional perusahaan tersebut. Tujuan penelitian ini adalah untuk mengetahui pengaruh pertumbuhan penjualan, kepemilikan manajerial dan kepemilikan saham publik terhadap pengungkapan Corporate Social Responsibility. Variabel dependen yang digunakan dalam penelitian ini adalah Corporate Social Responsibility. Adapun variabel independen yang digunakan adalah pertumbuhan penjualan, kepemilikan manajerial, dan kepemilikan saham publik. Populasi pada penelitian ini adalah perusahaan sektor kesehatan yang terdaftar di Bursa Efek Indonesia (BEI) untuk periode 2018 - 2022. Pemilihan sampel dalam penelitian ini menggunakan metode purposive sampling dengan total 16 perusahaan. Teknik analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa secara simultan seluruh variabel independen berpengaruh terhadap pengungkapan Corporate Social Responsibility. Hasil penelitian menunjukkan bahwa pertumbuhan penjualan berpengaruh negatif terhadap pengungkapan Corporate Social Responsibility, sedangkan kepemilikan manajerial dan kepemilikan saham publik tidak berpengaruh terhadap pengungkapan Corporate Social Responsibility. Kata kunci: CSR, Kepemilikan Manajerial, Kepemilikan Publik
Impacto de las variables sociodemográficas en los niveles de alfabetización financiera en México
Authors: Manrique Morteo Georgina , Salazar Núñez Héctor Francisco , Moreno García Elena
Published: July 2024

Objetivo: El objetivo de la presente investigación es analizar cómo las variables sociodemográficas influyen en el nivel de alfabetización financiera en la población adulta en México. Datos: Los datos se obtienen de la Encuesta Nacional de Inclusión Financiera ENIF (2021). Método: Se construye un índice de alfabetización financiera y a partir del coeficiente de correlación Pearson se mide la relación estadística que existe entre el índice y las variables edad, género, estado civil, localidad, nivel educativo y nivel de ingresos y se estima un modelo ANOVA para identificar la incidencia de las variables exógenas en el índice. Resultados: Los resultados obtenidos muestran que la variable nivel educativo es la que más impacta en el índice de alfabetización financiera, seguida por el nivel de ingresos de la población y que las variables género y estado civil tienen un impacto marginal. Originalidad: La forma de construir las variables exógenas, que dio origen al significado de los parámetros estimados del modelo econométrico. Hallazgos: Se identificó un impacto marginal en el índice en función del género, a diferencia de la importancia que tiene esta variable en la literatura científica sobre alfabetización financiera. Limitaciones: Casi el 90% de la población encuestada tiene un ingreso igual o menor a cuatro salarios mínimos, lo cual muestra la desigualdad económica de México.
Establishment of a Novel Fetal Ovine Heart Cell Line by Spontaneous Cell Fusion: Experimental Study (Preprint)
Authors: Suleiman Khalid , Aljulidan Mutaib , Hussein Gamaleldin , Alkhalaf Habib
Published: July 2024

BACKGROUND

The culture of immortal cell lines has become an indispensable tool in the field of modern biotechnology and has been used in the production of human and viral veterinary vaccines, therapeutic recombinant proteins, interferons, and monoclonal antibodies. Several approaches are used to immortalize cells in culture, such as transduction of cells with viral oncogenes, induced expression of telomerase reverse transcriptase, and spontaneous immortalization by serial passage of primary cell lines.

OBJECTIVE

This study aimed to establish an immortal cell line by serial passage of fetal ovine heart cells that could be used to produce veterinary viral vaccines.

METHODS

We serially passaged primary heart cells prepared from a fetal ovine heart till passage 140. We studied the events that led to the transformation and immortalization of the cell line under light and phase contrast microscopy. DNA samples of the cell line at passages 22 (before transformation) and 47 (after transformation) were genotyped according to single nucleotide polymorphisms (SNPs) using the OvineSNP50 BeadChip (Illumina). We sequenced the cytochrome b gene, control region, and tRNA-Phe and 12S rRNA genes of the mitochondrial genome of the cell line at passages 26 and 59 by Sanger sequencing. The susceptibility of the cell line to sheep pox, Peste des petits ruminants (PPR), lumpy skin disease (LSD), Rift Valley fever (RVF), and camel pox viruses was investigated.

RESULTS

We established a unique immortal cell line called fetal ovine heart–Saudi Arabia (FOH-SA) by serial passage of fetal ovine heart cells. We demonstrated that the transformation or immortalization of the cell line resulted from spontaneous cellular and nuclear fusion of 2 morphologically distinct cardiocytes at passage 29. Fused cells at passage 29 gave rise to progeny cells, which grew into multicellular filaments that persisted at passages 30, 31, and 32. Trypsinization of the filamentous multicellular growth at passage 32 gave an epithelial-type immortal heart cell line. SNP genotyping revealed 65% and 96% homozygosity in SNP genotypes of the cell line at passages 22 and 47, respectively. Partial sequencing of the mitochondrial genome of the cell line revealed mutational events in the control region and the tRNA-Phe and 12S rRNA genes of the mitochondrial genome of passage 59 cells. The cell line was found to be permissive to sheep pox, PPR, LSD, RVF, and camel pox viruses.

CONCLUSIONS

We established an immortal cell line by serial passage of primary fetal ovine heart cells, which was permissive to many animal viruses. It could be used in animal virus isolation, vaccine production, and biotechnology. The study reported spontaneous cell fusion of cardiocytes as a method of cell immortalization. The findings of this study might help address the mystery of how the VERO cell line evolved.
Continuous Monitoring of Heart Rate Variability and Respiration for the Remote Diagnosis of Chronic Obstructive Pulmonary Disease: Prospective Observational Study (Preprint)
Authors: Chen Xiaolan , Zhang Han , Li Zhiwen , Liu Shuang , Zhou Yuqi
Published: July 2024

BACKGROUND

Conventional daytime monitoring in a single day may be influenced by factors such as motion artifacts and emotions, and continuous monitoring of nighttime heart rate variability (HRV) and respiration to assist in chronic obstructive pulmonary disease (COPD) diagnosis has not been reported yet.

OBJECTIVE

The aim of this study was to explore and compare the effects of continuously monitored HRV, heart rate (HR), and respiration during night sleep on the remote diagnosis of COPD.

METHODS

We recruited patients with different severities of COPD and healthy controls between January 2021 and November 2022. Vital signs such as HRV, HR, and respiration were recorded using noncontact bed sensors from 10 PM to 8 AM of the following day, and the recordings of each patient lasted for at least 30 days. We obtained statistical means of HRV, HR, and respiration over time periods of 7, 14, and 30 days by continuous monitoring. Additionally, the effects that the statistical means of HRV, HR, and respiration had on COPD diagnosis were evaluated at different times of recordings.

RESULTS

In this study, 146 individuals were enrolled: 37 patients with COPD in the case group and 109 participants in the control group. The median number of continuous night-sleep monitoring days per person was 56.5 (IQR 32.0-113.0) days. Using the features regarding the statistical means of HRV, HR, and respiration over 1, 7, 14, and 30 days, binary logistic regression classification of COPD yielded an accuracy, Youden index, and area under the receiver operating characteristic curve of 0.958, 0.904, and 0.989, respectively. The classification performance for COPD diagnosis was directionally proportional to the monitoring duration of vital signs at night. The importance of the features for diagnosis was determined by the statistical means of respiration, HRV, and HR, which followed the order of respiration > HRV > HR. Specifically, the statistical means of the duration of respiration rate faster than 21 times/min (RRF), high frequency band power of 0.15-0.40 Hz (HF), and respiration rate (RR) were identified as the top 3 most significant features for classification, corresponding to cutoff values of 0.1 minute, 1316.3 nU, and 16.3 times/min, respectively.

CONCLUSIONS

Continuous monitoring of nocturnal vital signs has significant potential for the remote diagnosis of COPD. As the duration of night-sleep monitoring increased from 1 to 30 days, the statistical means of HRV, HR, and respiration showed a better reflection of an individual's health condition compared to monitoring the vital signs in a single day or night, and better was the classification performance for COPD diagnosis. Further, the statistical means of RRF, HF, and RR are crucial features for diagnosing COPD, demonstrating the importance of monitoring HRV and respiration during night sleep.
Ensuring GDPR Compliance and Security in a Clinical Data Warehouse: Challenges and Insights from a University Hospital (Preprint)
Authors: Riou Christine , El Azzouzi Mohamed , Hespel Anne , Guillou Emeric , Coatrieux Gouenou , Cuggia Marc
Published: July 2024

BACKGROUND

The digital transformation of health data has enabled the utilization of advanced data analytics and Artificial Intelligence (AI) techniques, which are crucial for driving innovation in healthcare. Countries such as France, the UK, Germany, and the US have adopted strategies to secure and ethically manage health data. In France, the Health Data Hub and clinical data warehouses (CDWs) within hospitals are central to this effort. However, the stringent regulatory framework, including the GDPR and French Data Protection Act, presents significant implementation challenges

OBJECTIVE

This paper aims to evaluate the applicability of the French CNIL CDW framework through an experiential analysis of its implementation and operational challenges in university hospitals within the French Great Western region . The study seeks to provide insights into the encountered obstacles and propose areas for improvement to enhance compliance and facilitate research.

METHODS

A detailed evaluation was conducted in may 2023 at the University Hospital of Rennes (CHU de Rennes) on the compliance of their eHOP CDW with the CNIL framework. The study categorized the framework’s requirements into those applicable to the eHOP software and those relevant to the institution's implementation. Each criterion was assessed by technical managers and data protection officers, with validation by information security officers.

RESULTS

Out of 116 criteria in the CNIL framework, 25 were identified as relevant to the eHOP software, with 15 criteria fully compliant, 7 non-compliant or partially compliant, and 3 not applicable. Institutional responsibilities covered 91 criteria, with several key areas identified as non-compliant or partially compliant, primarily involving security and governance measures. Notably, challenges in data retention management, encryption of sensitive genetic data, and robust authentication mechanisms were highlighted.

CONCLUSIONS

The study underscores both the benefits and challenges of implementing the CNIL CDW framework, emphasizing the need for technological and organizational adaptations to meet compliance requirements. Proposed adjustments aim to streamline research processes while maintaining stringent data protection. This evaluation offers valuable insights for other institutions and frameworks aiming to balance rigorous data protection with research and innovation needs. Future research should extend the scope to include multiple institutions and CDW technologies to validate and generalize these findings.
Factors That Affect the Quality of Life of Mothers Caring for Children With Medical Needs at Home: Cross-Sectional Questionnaire Study (Preprint)
Authors: Nakamura Kanako , Hamada Yuko , Fujita Ayaka , Morokuma Seiichi
Published: July 2024

BACKGROUND

The number of children requiring daily medical care is on the rise, with many being cared for at home. This situation places a significant burden on mothers, who often serve as the primary caregivers.

OBJECTIVE

This study aimed to clarify the factors that affect the quality of life of mothers with children who require home health care.

METHODS

A questionnaire study was conducted among mothers of children needing medical care at home, with 46 participants responding. The questionnaire included items regarding the child’s condition, the mother’s situation, and the World Health Organization Quality of Life-26scale.

RESULTS

Factors influencing the quality of life of mothers included whether the child attended daycare or school (β=.274; P=.04), the duration of home care (β=.305; P=.02), and the presence or absence of position changes (β=–.410; P=.003). The presence or absence of position changes had the most significant impact (adjusted R2=.327).

CONCLUSIONS

The most significant factor affecting the quality of life of mothers of children requiring home medical care is the presence or absence of positional changes.
Sprint-intensity arm interval training may improve cardiorespiratory fitness and cardiometabolic health among children with disabilities: case report (Preprint)
Authors: Dean Natalie , Sinha Tanvee , Bright Larsen , Ellison Katherine , Sayer Drew , Young Raven , Davis Drew , Rimmer James H , Lai Byron
Published: July 2024

BACKGROUND

There are limited aerobic exercise options for improving cardiorespiratory fitness and managing cardiometabolic health that are age-appropriate and suitable for children with mobility disabilities. Children with disabilities require exercise programs that have adapted movements for various functional needs, brief training durations to fit into busy scheduling, and remote training methods at home that bypass logistical transportation barriers.

OBJECTIVE

Test the potential effects and safety of a sprint-intensity arm-exercise interval training program, combined with music and telehealth, on cardiorespiratory fitness and cardiometabolic health in a child with cerebral palsy.

METHODS

Pre to post trial design with a 12-week exercise intervention for a single child with cerebral palsy (age 17 years). The intervention was performed by the participant at the home. The participant exercised three times per week while following along with YouTube exercise videos. Videos included four second maximal sprint bouts followed by periods of rest, which were repeated 30 times during a single exercise session (total of ~2 minutes of maximal exercise). Exercise sessions were supervised by research staff using videoconference. Cardiorespiratory fitness was indicated by peak oxygen consumption pVO2 that was measured by a portable metabolic cart during a graded exercise test. Cardiometabolic health outcomes included body composition by dual-energy X-ray absorptiometry scan and a cardiometabolic blood-profile by a dried blood spot test. Outcomes were descriptively analyzed.

RESULTS

The participant achieved a 33.6% increase in pVO2 (14.6 to 19.5 mL/kg -1 /min -1 ), 37.8% improvement in blood triglycerides (82 to 51 mg/dl), and 15.4% improvement in total cholesterol to high-density lipoprotein ratio (6.5 to 5.5). Additionally, he had a 5.9% reduction in body weight (171 to 161 lbs), and 9.6% reduction in total body fat (61.35 to 55.48 lbs) from the arms, legs, and trunk. The participant experienced no adverse event or problems during the intervention. After completing the program, the participant was capable of eliciting a maximal intensity of exercise using armbands, as demonstrated through pVO2.

CONCLUSIONS

Sprint-intensity interval training, using the arms, may be safe and potentially effective for improving cardiorespiratory fitness and cardiometabolic health among children with physical disabilities. Further research is warranted to confirm the findings of this case report.
Research on Legal Issues of Financial Fraud in Listed Companies
Authors: Zhang Ke
Published: July 2024

In the rapidly developing economy, with the increasing frequency of socio-economic activities, the number of listed companies is also growing. As an important part of China's non-state-owned economy, the information disclosure of listed companies is particularly important and serves as a crucial indicator for small and medium investors. However, in the prosperous market economy, some listed companies, in order to attract more investors, resort to financial fraud, such as issuing false invoices, creating fictitious transactions or related party transactions, and other means to inflate profits and deceive investors’ funds. This undoubtedly undermines China’s socio-economic order and reduces the public’s trust in the securities market. Due to the imperfect market economy rules, inadequate legal system, and incomplete internal control systems in China, financial fraud occurs very frequently. Financial fraud not only harms the interests of small and medium investors but also disrupts the social and economic order. Next, this paper will explore the means and motivations of financial fraud to delve into the essence of financial fraud.
Комплект кулачков в сборе к тяжелому токарному станку 1А670
Authors: Сорокин А.В.
Published: July 2024

Производством ООО ПКФ «СтанкоАртель» освоено изготовление кулачков в сборе к тяжелому токарному станку
КТ СЕНСОРС – мы осознаем свою социальную ответственность!
Authors: Кравченко В.
Published: July 2024

Международная корпорация Balluff,
специализирующаяся на технологиях
промышленной автоматизации, прекратила работу
на российском рынке в 2022 году. Организацию
технической и сервисной поддержки поставленных
ею изделий взяла на себя компания «КТ СЕНСОРС»,
созданная на базе ООО «БАЛЛУФФ», российской
«дочки» концерна Balluff. О деятельности
предприятия и оказываемых им услугах нашему
изданию рассказал генеральный директор
«КТ Сенсорс» Василий Кравченко.
Image Categorization through Convolutional Neural Network
Authors: Kumar Harsh
Published: July 2024

Abstract: Ten years ago, there were barriers to ideal accuracy in many computer vision issues. But the emergence of deep learning techniques brought about a dramatic change that greatly improved the accuracy of these problems. Among these, image classification stands out as a key problem: it is the challenge of accurately classifying images into their corresponding classifications, such dogs and cats. This research aims to improve accuracy by utilizing state-of-the-art object detecting algorithms. In order to tackle this, a great deal of effort has gone into building a convolutional neural network (CNN) that is robust and designed with image categorization in mind. The principal goal is to leverage the capabilities of cutting-edge object identification techniques in order to achieve significant improvements in image classification accuracy.
A Practical Study on Concrete by Partial Restitute of Cement by Orange Peel Ash in Additive with Polypropylene Fibers on M40 Mark
Authors: Bee M. Jahera
Published: July 2024

Abstract: Researchers have been looking at several materials to make concrete more sustainable in the past few years. The nutritional and therapeutic benefits of orange fruits have kept them in human diets for centuries. However, improper disposal of the orange peel wastes produced by fruit eating poses risks to both human and environmental health. The study's overarching goal was to develop environmentally friendly engineering material additions for use in concrete, with a secondary objective of reducing trash pollution and littering. With a focus on the strength properties of OPA-cement blends for cement replacement ranging from 0-10% at 2.5% intervals, this investigation will examines the potential of orange peel ash (OPA) as a cement replacement material. The effect of varied % additions of OPA on the qualities of fresh concrete was investigated experimentally by measuring consistency, fineness of cement, soundness of cement, setting times, workability, compressive, split tensile strength and flexural strengths. An ideal concentration of 0%, 2.5%, 5%, 7.5%, and 10% of OPA admixture was determined, and consistency improved with increasing additions on M40 Grade of Concrete.
Calculation of Reinforced Concrete Frames for a Special Design Situation with Discrete Crack Modeling
Authors: Savin S. Yu. , Iliushchenko T. A.
Published: July 2024

The methodology of calculation of reinforced concrete frames of buildings for a special design situation caused by initial local failures, taking into account the violation of the continuity of the concrete matrix during crack formation, is proposed. The verification of the proposed methodology is carried out by comparing it with the results of experimental data for a U-shaped reinforced concrete frame with prestressing. The bending moments in the frame, determined by the proposed calculation method, are in practically complete agreement with the values found experimentally. As a result of cracking, there was a redistribution of bending moments in the beam of the frame: the moments in the structural nodes decreased by 148 % and increased in the span by 37.5 % compared to the results obtained using the traditional finite element method approach. On the basis of the results of the calculation of the reinforced concrete 3-storey frame by the proposed method, the increase of longitudinal tensile forces in the beam support sections above the zone of local failure at failure of the middle row column is revealed in comparison with the traditional approach to modeling. The revealed effect may lead to an increase in the influence of longitudinal bending for the outermost row column to which the beam is adjacent.
Pengelolaan Sampah Dengan Menggunakan Model Penta Helix Untuk Pembangunan Berkelanjutan: Studi Kasus TPA Supit Urang Kota Malang
Authors: Mohamad Arif  , Sumarmi  , Tuti Mutia  , Ravinesh Rohit Prasad
Published: July 2024

Sampah menjadi masalah yang cukup serius di kalangan masyarakat maupun pemerintah. Sampah yang masih belum terkendalikan dengan benar akan mengakibatakan berkurangnya daya dukung lingkungan. Peran berbagai sector atau elemen masyarakat perlu untuk ditingkatkan. Tujuan dari artikel ini adalah mengetahu dan menggambarkan pengelolaan sampah yang ada di TPA Supit Urang yang berada di Kota Malang dan menggunakan kolaborasi penta helix yaitu keterlibatan pemerintah, masyarakat madani, perguruan tinggi, lembaga swadaya masyarakat dan swasta untuk meningkatkan pengelolaan sampah yang berwawasan lingkungan. Elemen-elemen ini diharapkan bisa menciptakan pengelolaan sampah yang berwawaskan lingkungan sehingga dapat mengatasi permasalahan sampah di TPA. Artikel ini disusun dengan menggunakan metode deskriptif kualitatif dengan melakukan survei dan wawancara terhadap pemangku kepentingan terkait dengan sistem pengolahan sampah yang ada di TPA Supit Urang. Berdasarkan hasil analisis model penta helix peran pemerintah dalam pengelolaan sampah di TPA Supit Urang Kota Malang sudah cukup bagus karena terdapat regulasi yang mendukung peningkatan pengelolaan sampah, peran lembaga swadaya masyarakat juga sudah baik, peran perguruan tinggi melalui riset juga sudah cukup bagus namun masih perlu untuk ditingkatkan lagi, peran elemen swasta dan elemen masyarakat madani perlu untuk perhatian khusus dan peningkatan lagi. Jika semua elemen pada model penta helix ini dapat berjalan bersama dengan baik maka akan tercipta TPA yang ramah lingkungan dan akan terwujudnya Sustainable Development Goals (SDGs) melalui pengelolaan sampah yang tepat dan berkelanjutan.