bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytoremediation of Lead Contaminated Land Using Vetiver zizanoides and Citric Acid as Chelating Agent
Authors: Shinta Yesi Clara , Sumiyati Sri , Zaman Badrus
Published: October 2022

Environmental pollution due to hazardous waste in Karangdawa, Margasari, Tegal has an impact on soil and groundwater quality. Lead found in the soil exceeds the permissible standards. It is necessary to recover soil from Lead because it can enter food crops and accumulate in the human body. Phytoremediation is commonly used in land remediation because it’s economical and doesn’t cause secondary environmental problems. One of the ways to optimize Phytoremediation is by using chelating agents. The purpose of the study was to analyze the ability of Vetiver zizanoides and analyze the most optimum dose variation of Citric acid to uptake Lead to the plant. The ability of Vetiver zizanoides and Citric acid as metal chelators in Pb uptake was investigated for 28 days with Citric acid doses of 0.5 g/kg, 1 g/kg, and 2 g/kg. Analysis of Lead concentration in roots, stems, and soil using AAS. From the results of the study, Vetiver zizanoides was able to survive from Lead exposure up to 4979.8 ppm. Application 1 g/kg of Citric acid in the soil, increased the bioconcentration, and bioaccumulation compared to control plants. The results indicated that the addition of Citric acid as a chelating agent could increase the function of Vetiver zizanoides as a phytoremediation agent.
“Dirty Energy” and Ecological Performativity in Contemporary English Poems: Critiquing Petro Culture of the Anthropocene
Authors: Joko Yulianto Henrikus , Anam Zuhrul
Published: October 2022

Fossil fuels will always take command of human’s daily life. Despite being “dirty energy”, humans cannot jettison them since they are the mainstay for multipurpose energies. They are more dependable and accessible than renewable energy sources such as hydropower, solar panel, and wind power. Even more so, in this present globalization the increasing scale of consumerism via digital technology and social media consumes the fuels. This petro-overconsumption of the fuels and their derivative products such as plastic certainly has some detrimental impacts: the more emission of carbon dioxide and other toxic particles to the atmosphere. Contemporary English poems are some works that critique the petro-overconsumption. A Canadian poet, Stephen Collis in his poem “Take Oil & Hum”; a Hawaiian poet, Craig Santos Peres in his poem about plastic, “The Age of Plastic”; and two Indonesian poets, AfrizalMalna in “petrol cupboard” and F. Aziz Manna in “Estuary” are the epitome of ecopoems that share this concern. With their performative interiorizing of petro-materiality, their depiction of petro-transcorporeality from one form into another, they articulate the polemics and impacts of non-renewable energy on human and nonhuman creatures as the issue of ecological precarity in the era of anthropocene.
Natural Resources for The Nation's Prosperity (A Semiotic Study of the Song "Indonesia" by Rhoma Irama)
Authors: Muzakka Moh. , Prihatini Maghfiroh Dewi
Published: October 2022

The purpose of this study is to describe the meaning contained in the song “Indonesia” by Rhoma Irama in relation to the use of natural resources for Indonesian’s prosperity. This song is considerably popular during the New Order era as the author critics to the problem happened in his country. The circumstance captured on the song “Indonesia” is still relevant to the current state of the nation. To reveal the implied meaning from the song, researchers using a semiotic approach for poetry. Data collection is done through literature study with listening and note-taking techniques. After the data has been gathered, it is analyzed using a semiotic approach initiated by Michael Riffatere. The results of the analysis show that the government has to manage the wealth of Indonesia's natural resources properly, not only for certain individuals but also the others. It is because the author believes that Indonesia's natural resources can hugely support the nation, both people and the country, if it is managed properly by the government.
Lexical Cohesion in Song Lyrics of “Malapetaka”, “Bencana”, and “Kemarau” by Rhoma Irama
Authors: Sapna Hassya Ancelia , Astuti Sri Puji
Published: October 2022

Humans must maintain cleanliness, safety, and environmental sustainability. A well-maintained environment makes humans’ life more comfortable. In creating song lyrics, Rhoma Irama often uses vocabulary related to the environment. This can be seen in the lyrics of his songs, among others, entitled "Malapetaka", "Bencana", and "Kemarau". The message conveyed in the lyrics of the song uses language that is interesting and easy to understand. Therefore, in the lyrics of this song, it is suspected that cohesion markers are used. Based on this background, this study reveals what lexical cohesion markers are used in the three song lyrics. Data collection is done by listening to the use of the language used in the lyrics of the song and then proceeding with the note-taking technique to record fragments of discourse that contain lexical cohesion contained in the lyrics of the song. The data was analyzed using cohesion theory, especially lexical cohesion. Based on the results of the study, it was found that to form coherent lyrics in the lyrics of the songs “Malapetaka”, "Bencana", and "Kemarau", lexical cohesion markers were used in the form of repetition, synonyms, hyponyms, and collocations.
Contrastive Analysis of Onomatopoeic Use in Nursery Rhymes as Children’s Environmental Sounds Recognition in Japanese and Indonesian
Authors: Rosyadi Naila Nabila , Hastuti Nur
Published: October 2022

Nursery rhymes play a role in children’s language development and help them recognize and express the environmental sounds or sounds around them. Onomatopoeia or imitation words are often found in nursery rhymes. Every country has a different language, so it has different phonetic sounds to express onomatopoeia. In this research, the author will contrast the onomatopoeic use in Japanese and Indonesian nursery rhymes. The theory and classification of onomatopoeia used in this research are combinations proposed by Akimoto (2002) and Kaneda (1978). This qualitative research used the listening and note-taking methods from Youtube videos. The analysis data used in this research are the referential matching method. The result from the research data shows that in Japanese nursery rhymes, onomatopoeia is the sound of nature, the sound from an object, the sound of a human, the sound of an animal, object condition, object movement, human movement, animal movement, and human emotion are found. Meanwhile, in Indonesian nursery rhymes found, almost all types of onomatopoeia in Japanese are found except for the class of the sound of a human, object movement, and human emotion are not found.
The Relationship Between Metacognitive Experiences and Digital Literacy in a Self-Directed Learning Environment
Authors: Irhandayaningsih Ana , Mulana Hastoto Sufyan
Published: October 2022

The learning environment in universities that use a learning management system requires students to study independently. This study investigates a digital literacy assessment model with additional instruments from a knowledge management perspective. The model has been tested on 50 students in the Department of Library Science, University of Diponegoro, who were selected using a purposive sampling technique. The results of the assessment were analyzed using regression and showed that metacognitive was the dominant predictor.
Jlamprang Batik Patterns as Pekalongan Local Wisdom of Using Batik Technique
Authors: Atrinawati Atrinawati
Published: October 2022

As Batik City, the branding launched by the local government to celebrate the city’s 105 years anniversary on April 1st, 2011, Pekalongan has particular and unique batik called ‘batik pesisiran’ that has different colour and motive from Yogyakarta or Surakarta batik. Jlamprang is one of five original batik motives which was initially created to substitute Indian patola woven fabric pattern as it has geometric patterns consisting of dot, circle, and square with padma flower in the middle of the circle resembling the Indian patola pattern. The research shows how Jlamprang batik motive is found, how it is developed into batik motive, and how it is utilized by the local people. The data were obtained by using literature review on Jlamprang batik motive, observing its use, and interviewing the local people who understand well about it and its use. The result shows that although the local people understand Jlamprang history and use it for their benefit, such as producing and wearing batik with the motive and using it for handicraft or decoration; Jlamprang batik motive starts to be forgotten as it is less preferred by common buyers who preferred more popular or stylish motive than the ordinary and plain geometric ones.
Parties and Environmental Issues: PDIP Action Programs in the Reformation Era, 2002-2014
Authors: Wilujeng Pramestusi Agustina , Rochwulaningsih Yety , Sulistiyono Singgih Tri
Published: October 2022

This paper examined programs implemented by a political party, in this case the Indonesian Democratic Party of Struggle (PDIP), during the 2002-2014 period. The reform era has brought environmental issues to the fore with worsening environmental degradation attributed to the implementation of Law Number 23 of 1997 concerning Environmental Management (UUPLH), which was considered to be substantially, structurally, and culturally weak. The high level of conflict in the management of the environment and natural resources (SDA) has led to demands from environmental activists for political parties to raise environmental issues in their election campaigns (Election 2004). Reflecting on the 1999 election, as mentioned in the source, only four political parties were deemed to have paid attention to environmental issues - PDIP, the National Mandate Party (PAN), and the National Awakening Party (PKB). Basically, according to PDIP’s perspective, having a great concern for environmental problems is a prerequisite to addressing environmental damage. In this regard, concrete steps taken by PDIP in overcoming environmental problems need to be explored. Using the historical method, it was found that PDIP, which won the 1999 general election and became the top three in the 2004 election, consistently paid attention to environmental issues. This concern was demonstrated not only by incorporating environmental issues into the content of the election campaign but also by implementing disaster prevention and management action programs. Prevention was carried out, among others, through regular tree planting activities and adapting to the natural conditions of each region. Meanwhile, the disaster emergency response program was carried out by PDIP through the PDIP Disaster Management Agency (Baguna).
The Enlightenment of Indian Institute of Technology: Autonomy, Selection and Practical Education
Authors: Jiang Yueying
Published: October 2022

Indian Institute of Technology (IIT) is one of the most famous universities in the world, and its history witnessed the development of Indian higher education. The unique management mode and educational philosophy have played an important role in its success story and given a strong boost to become one of the world-class universities. This paper explores the successful experience of IIT, which can be summarized in the following three aspects. Firstly, a high degree of autonomy and academic freedom ensure a good academic reputation. Secondly, based on rigorous selection and assessment, the IIT students work their way to the top of their profession. Lastly, the emphasis on practical education and the system of industry-university-research integration work together to promote the productivity transformation of academic achievements. These distinctive characteristics of management and talent cultivation system boost the development of IIT and make it outstanding. The success of IIT can be used as a reference and provide enlightenment for the construction of world-class universities in China. It inspires universities in China to make changes in the management system, entrance selection and talent cultivation.
A Study of The Metaphor of The Internet Buzzword “corporate slave” in The Context of Semantics
Authors: Lu Chuying
Published: October 2022

From January 2022 to July 2022, the average daily Baidu search index for the term “corporate slave” was 2,266 times. Meanwhile, the search result of Sina Weibo for the term “corporate slave” was 1523880, and the search result of Baidu was 5510000. The term “corporate slave” originated in Japan and was later introduced to China, and within a short period, it caused widespread use and phenomenal discussions on the Internet. The explosion of this exotic word is not only accidental but also inextricably linked to the current Chinese society, Internet ecology, and young adults’ thinking. Therefore, this paper analyzes the metaphorical meaning of the term “corporate slave” and the thoughts of young adults in China as reflected by its widespread use in the context of the current social development. The study of Japanese-derived vocabulary can not only promote the exchange between Chinese and Japanese cultures, but also learn more about the philological meaning of Internet buzzword.
The Impact of Self-control on Graduation Anxiety among University Students in Nanjing during the COVID-19
Authors: Xu Lanwei
Published: October 2022

This study took 2018 full-time undergraduates in Nanjing to explore the relationship between self-control and graduation anxiety during COVID-19, which provides a basis for promoting the mental health of college graduates.
Research on the Promotion Strategy of Scientific and Technological Innovation Ability in Guangdong Vocational Colleges from the Perspective of “Double High” Construction
Authors: Dong Jian , Xie Jianru , Guo Yintong
Published: October 2022

Improving the technological innovation ability of vocational colleges is a necessary condition for more precise docking of industrial needs and deeper development of school-enterprise integration, which is of great significance for deepening the connotation of “double high” construction. After investigating the mode of improving the scientific and technological innovation ability of vocational colleges in Guangdong, the experience and practice are refined and summarized, and the factors affecting the development of the mode, such as the backward basic conditions of scientific research, the weak consciousness of teachers in scientific research, and the lack of effective mechanism to guarantee the continuous innovation ability of the school-enterprise collaborative innovation platform, are clarified. Some suggestions are put forward that vocational colleges should increase the investment in scientific research and the education of scientific and technological talents, create a good scientific research atmosphere and innovate the cooperation mechanism of scientific research between universities and enterprises.
A Study on Cross-cultural Adaptation Problems and Countermeasures Research for Malaysian Students in Tianjin
Authors: Wang Chunshuang
Published: October 2022

With the development of economic globalization, the number of students studying in China has been increasing in recent years. This has brought opportunities and challenges to the development of international student education. How to improve the cross-cultural adaptation ability of international students and enable them to have a better study life in China is a huge challenge to the receiving institutions, and it also plays a decisive role in the implementation of the national economic strategy. Especially in recent years, in order to strengthen exchanges between China and Malaysia, the Malaysian government has vigorously promoted Chinese cultural education, which has led to an increasing number of students studying in China. This paper investigates the study and life of Malaysian students from 8 universities in Tianjin, and systematically analyzes the countermeasures from the three aspects of psychological adaptation, social and cultural adaptation and academic adaptation, so as to improve the management ability of international students of the universities in Tianjin.
The Impact of the U.S. Occupation on Japanese Politics and Economy after the End of World War II
Authors: Liu Xinran
Published: October 2022

During WWII, the US and Japan are enemies, however, after the war, the US occupy Japan and transform it into nowadays Japan. This paper analyzes the impact of the US occupation of Japan after the end of WWII on Japanese politics and economy by using the method of studies literature review. This paper also explores the process that makes Japan transform from feudal militarism into a parliamentary democracy country and summarizes the contributions of the US to Japan’s rebuilding. It can be concluded that the rise of nowadays Japan is built on the foundation of the influence of the US during the occupation.
Analysis of the Characteristics of Digital Content with High Freedom in Interactive AVG Games
Authors: Wang Siyu
Published: October 2022

With the growth of the female economy, many games have emerged in recent years that specifically focus on female players as their main customer group. A new form of game, the interactive AVG game, offers players higher autonomy and interactivity, attracting a large number of female players. This paper studies a popular interactive AVG game, Melody from Harem, based on its rich digital content, such as digital storytelling, game mechanics, spatial properties and game goals, to investigate the design strategies of games with female target user group. AVG games are currently in a double marginal position in the game industry and academic, but they have a higher user retention rate beyond that of mainstream games. Therefore, the research on AVG games is of great significance to the development of China’s female digital game market. The study found that interactive AVG games adopt the strategy of involving players in story narration, and through rich interactive game mechanics, appropriate setting of scenario element, both absolute and relative goals to ensure players’ interactivity, autonomy, immersion and pleasure value in the game, and ensure that the game can gain high user stickiness with players’ loyalty. With the development of women’s games, the excessive sexualization of female images in traditional digital games has been corrected, but it has not completely disappeared, and female stereotypes can still be seen in some games.
Research on the Factors Influencing the Quality of Family Business Information Disclosure From the Perspective of Social Emotional Wealth Theory
Authors: Huang Lianfan , Xie Hong
Published: October 2022

Based on the theory of social emotional wealth, social emotional wealth is divided into two types: constraint type and extension type. Using the data of family businesses from 2015 to 2020, empirical research is conducted on the impact of two types of social emotional wealth on the quality of information disclosure, It also examines the moderating effect of institutional investor ownership and analyst concern on the relationship between emotional wealth and information disclosure quality in a constrained society, as well as the moderating effect of parental founder status and second generation experience length on the relationship between emotional wealth and information disclosure quality in an extended society. The findings are as follows: (1) Constrained social emotional wealth negatively affects the quality of information disclosure of family businesses; (2) Extended social emotional wealth has a positive impact on the quality of family business information disclosure; (3) The higher the shareholding ratio of institutional investors, the weaker the relationship between the constrained social emotional wealth and the quality of family business information disclosure; (4) Analysts focus on the relationship between the negative impact of social emotional wealth and corporate information disclosure; (5) The paternal founder status can positively affect the relationship between the extended social emotional wealth and the quality of information disclosure of family businesses. (6) The second generation experience did not positively affect the relationship between extended social emotional wealth and family business information disclosure.
The Interpretation of Contemporary “New Mainstream” Cinema
Authors: Kuang Yuxuan
Published: October 2022

The new mainstream film is an upgraded version of the main theme film, which is more commercial, entertaining and popular. The themes are more extensive, and the casting is bolder and more grounded. Nowadays, the rise of new mainstream films also means that Chinese films have embarked on a new journey. A new type of film that combines artistry and commercialism skillfully has its unique advantages from both artistic and commercial perspectives.
Reexamination of Orientalism by the Protagonist’s Psychological Interiority in Concert with Setting Description in The Painted Veil
Authors: Liu Meiru
Published: October 2022

In The Painted Veil, the setting descriptions serve as an apparatus to reveal the protagonist Kitty’s mental or emotional status for that her psychological interiority is projected onto these external objects, which T.S. Eliot named Objective Correlative. Through this angle, this paper reexamines certain Orientalism related topics and previous critiques. This paper analyzes how Kitty’s psychological world and setting descriptions coordinate to indicate Kitty’s transformation. The transitional process of Kitty’s attitudes towards China and Chinese and the development of Kitty’s perception of life are explored. Intriguingly, this paper tempts to prove that some critiques against Maugham and the novel may be prejudice-oriented or evidence insufficient.
A Comparative Study of the Translation of “Xiao” in The Analects of Confucius Based on LancsBox
Authors: Guo Yuqing
Published: October 2022

“ Xiao” is the foundation of traditional Chinese culture, and The Analects of Confucius, as an important part of traditional Chinese classical culture, is an indispensable sample for the study of Chinese “Xiao” culture, and has an irreplaceable position in the history of the foreign dissemination of Chinese classics. The English translation of The Analects of Confucius by Chinese and Western translators has its own distinctive features. This paper takes the English translations of The Analects ofConfucius by Ku Hung-Ming and James Legge as an example, and uses LancsBox, a new corpus analysis tool, to compare the similarities and differences of their translations of the core concept word “Xiao” and the reasons for the differences in translation. The author also proposes some suggestions for the future translation and dissemination of the Chinese classics from the English translation of “Xiao”.
Public Relations between British Museum and Chinese Audience
Authors: Peng Ruoyu
Published: October 2022

In the era of new media, the external publicity of museums should also actively use new media thinking and new media tools. Web pages are one of the main new media tools for external publicity of museums today, or they can be called the “facade on the Internet” of museums. This paper attempts to understand the public relations between the British Museum and Chinese audiences through the comparison of the layout and content of the British Museum’s Chinese and English homepage, including the perfection of its communication information, the frequency of maintaining the website, the aesthetics of the layout design, etc., in order to get a glimpse of the attitude of the British Museum towards Chinese audiences.
South Asia’s Security Dilemma: How India and Pakistan Lost Policy Flexibility in the Kashmir Conflict
Authors: Wang Wei
Published: October 2022

The South Asian subcontinent has seen many conflicts and wars over Kashmir, and Kashmir is at the heart of the conflict between India and Pakistan. Historically, India has gained the upper hand in many conflicts. However, both sides remain in a “security dilemma.” This security dilemma is not limited to the military, but is an all-encompassing “security dilemma.” Currently, such as territorial conflicts, security challenges, energy shortages, resource scarcity, arms race, and geopolitical wrangling has led to India-Pakistan relations remaining rife with suspicion and mistrust. The most difficult issues can be resolved if the two countries review and revise their policies and postures and make progress in building bilateral trust. This paper will examine the impact of the Kashmir conflict on the security dilemma between India and Pakistan and will discuss how both sides have lost flexibility in the security dilemma, which, by default, demands further studies on the subject.
Analysis on Rational Correction of Application Scope of Voluntary Surrender System in China
Authors: Gao Zijian
Published: October 2022

In the practice of voluntary surrender system in China, especially in cases of residual voluntary surrender, voluntary surrender system will be apparently invalid if the suspect brought to justice mistakenly thinks his or her behavior constitutes a crime due to wrong legal understanding and then confesses it, while such a crime is only an infringement act of legal interest in accordance with objective elements of the crime. It can also be concluded that such special cases are not applicable to confession and even merit system. Based on the different perspectives of utilitarianism, labeling theory, and legal economics, the negative impact of the above-mentioned defects can be seen. And not only that, it also reflects that it is reasonable to correct the application scope of voluntary surrender system.
Two Decades and More: Evolution of Netflix’s Business Models and Outlook of Future
Authors: Sun Xinyang
Published: October 2022

This paper aims to study the growth of Netflix as one of the most successful multinational corporations in the entertainment industry. SWOT analysis is used as the theoretic frame to analyze the different combinations of strategies that Netflix has taken under various circumstances. Based on the focus shift, this paper divides Netflix’s history into three periods: freshly established as a movie rental business, domestic (United States) streaming services provider, and international streaming content creator and service provider. SWOT analysis is then used to examine the strength and weaknesses of Netflix and the opportunities and threats it faces in different periods, providing an overview of its circumstances. Comparing the different combinations of strategies that Netflix has taken at different growing stages, this paper has found out that Netflix has always emphasized its strength such that its strategies are mostly strength-radiated. Even though its strength is constantly changing from time to time due to the intense competition present in the markets, the strength-based approach has allowed it to explore opportunities or overcome threats. During the global expansion period, Netflix has also raised its attention on improving its weakness, potentially due to the stronger competitors in the international streaming market. Nowadays, Netflix has become the leading company in the global streaming industry, evident by its continuously greatest market share in recent years. However, as the whole ecosystem grows, Netflix must make sure it can grab the potential opportunities of faster broadband speed and upgraded accessories, especially in this era, where the boundary of different types of entertainment remains unclear, giving rise to even more powerful potential competitors, such as Tiktok, for people’s limited leisure time.
An Alternative Approach to Post-industrial Rejuvenation in Westport Waterfront, Baltimore
Authors: Zhang Keren
Published: October 2022

In order to prevent the loss of residents, provide job opportunities, attract people of all economic backgrounds, and make efficient use of land resources, this paper explores how to use alternative methods to create an equitable, sustainable and productive communities that contributes to the well-being of the existing communities by reusing the post-industrial property. Furthermore, this article examines how post-industrial landscapes might be designed to link residents and reanimate communities.
Changes in Türkiye’s Perception of International Regions and Main Reasons
Authors: Han Xiaolai
Published: October 2022

Since the establishment of the Turkish Republic, it has two options for the international regions, “westward” and “eastward”, one of which has dominated at different times in its history. The change of the Republic of Turkey’s Perception of International Regions encompasses the period from Kemal to the post-Kemal era, from a ’westward’ to an ’eastward’ strategy, from a Euro-Western focus to a return to the Middle East-Islamic world. Turkey regional perspective is rooted in its national characteristics including geography, history, and ethnicity, religion and language, while the core reason for the specific changes is national interests. Nowadays, as a regional power, Turkey is on its way to becoming a global power. With some regional achievements, it sees itself as the centre of Eurasia-Africa and works on a comprehensive regional cooperation strategy. However, Turkey is not strong enough to support its ambitions, which might cause new problems in the future.
Analysis of the Introduction of Non-denominated shares
Authors: Duan Nan
Published: October 2022

With the enactment of the Company Law (Amendment) Act 2021 and the public consultation, the authorized capital system began to be accepted by our company law. Closely related to it, the system of non-denominated shares was also confirmed in the draft. For a long time, China has been practicing the par value share system, which undoubtedly played a role in safeguarding the equal capital contribution relationship among shareholders, preventing the company from improperly distributing dividends, protecting the company’s continuous operation and being solvent under the framework of the early company law theory. However, with the development of the market and corporate governance, the actual function of the par value share system seems to be gradually deviated from the original purpose of its establishment. The purpose of this paper is to demonstrate the advantages of implementing a system of non-denominated shares, and also to suggest some supporting institutional arrangements after the introduction of non-denominated shares.
The Influence of Social Attribute in Games on Consumers - The Example of The Phone Game “Honor of Kings”
Authors: Zhang Zhikun
Published: October 2022

With the continuous development of the gaming industry, more and more manufacturers are joining the competition in the gaming industry. This study takes “Honor of Kings” as an example and proposes a novel factor that influences game consumers - social attributes. The study focuses on two aspects: ’Why it has social attributes’ and ’How social attributes affect consumers’. It gives players an understanding of the concept of social attributes and provides game manufacturers with a novel direction to improve the revenue of their games.
Study of Yang's Onion Flap Technique for Release of Scarred Eponychium and Nail Fold Reconstruction in Burn Patients
Authors: Srivastava Vaishali , Sharma Upendra , Rathore Deepak
Published: October 2022

Background Abnormalities of fingernail growth and appearance are among the most common deformities encountered after burn injury to the hand. Various techniques used for resurfacing defects include incision of the scarred eponychium and advancement of the distal segment, flap reconstruction-distally, and proximally based transposition/advancement flaps, composite graft techniques, microvascular transfer. In the present study, we used an onion flap to release scarred eponychium and nail fold reconstruction in a single stage without using soft tissue from another area.

Materials and methods Forty-four burnt fingers were operated using Yang's onion flap technique. Patients were assessed for flap necrosis, hematoma and infection in the early postoperative period and for donor site scar, nail appearance, and symptomatic relief in a follow-up for at least 4 months.

Results The flap was successfully performed on all fingers. Only two fingers had flap necrosis. There was no incidence of hematoma or infection. The donor site scar and nail plate appearance improved and was acceptable to most patients after surgery. There was also significant relief in daily activities in 19 out of 28 symptomatic patients.

Conclusion Yang's flap to correct nail deformities in burn patients is feasible in Indian scenario. It is associated with a low complication rate and improved nail appearance. There is also significant symptomatic relief in performing daily activities after surgery.
Imaging invisible tissues with Ultrashort Echo Time magnetic resonance
Authors: Piccone Ashley
Published: October 2022

Components in the body with short relaxation times, such as menisci, ligaments, tendons, bones, and myelin, could be captured with improvements to MRI.
Spectrum characteristics for internal wave signals of a self-propelled model
Authors: Chen Xin , Sheng Li , Xie Zhimin , Jia Di , Shuai Chang-geng
Published: October 2022

Internal waves induced by an underwater self-propelled body expose its existence by changing the sea surface roughness. This study employs short-time Fourier transform to perform the time–frequency analysis on the internal wave signal captured in the experiments. Some key characteristics of the underwater self-propelled body are obtained through the spectrum analysis of the internal wave wake signal. Moreover, the influence of the interaction between the momentums induced by the propulsion and drag force is discussed. The results show that the action of the self-propelled body has varying degrees of influence on the symmetry and spatial distribution of the spectrum characteristics of the signal.
Reviving keV sterile neutrino dark matter
Authors: Jaramillo Carlos
Published: October 2022

We propose a new production mechanism for keV sterile neutrino dark matter which relies neither on the oscillations between sterile and active neutrinos nor on the decay of additional heavier particles. The dark matter neutrinos are instead produced by thermal freeze-out, much like a typical WIMP. The challenge consists in balancing a large Yukawa coupling so that the sterile neutrinos thermalize in the early universe on the one hand, and a small enough Yukawa coupling such that they are stable on cosmological scales on the other. We solve this problem by implementing varying Yukawa couplings. We achieve this by using a three-sterile neutrino seesaw extension to the SM and embedding it in a Froggatt-Nielsen model with a single flavon. Because the vev of the flavon changes during the electroweak phase transition, the effective Yukawa couplings of the fermions have different values before and after the phase transition, thus allowing for successful dark matter genesis. Additionally, the hierarchy in the flavour structure is alleviated and the origin of the light neutrino masses is explained by the interplay of the seesaw and Froggatt-Nielsen mechanisms.
Irrigation can create new green bridges that promote rapid intercontinental spread of the wheat stem rust pathogen
Authors: Bradshaw Catherine D , Thurston William , Hodson David , Mona Tamás , Smith Jacob W , Millington Sarah C , Blasch Gerald , Alemayehu Yoseph , Gutu Kitessa , Hort Matthew C , Gilligan Christopher A
Published: October 2022

Wheat stem rust epidemics caused by the obligate pathogenic fungus Puccinia graminis f.sp. tritici have historically driven severe yield losses on all wheat growing continents and, after many decades of control, stem rust is re-emerging as a disease of concern. In 1998, a highly virulent race able to overcome 90% of world wheat cultivars, Ug99, was identified in Uganda. Since initial detection, the pathogen has evolved many new variants and spread to many countries. The original variant spread from East Africa to the Middle East with three years between detection in Ethiopia and subsequent detection in Yemen. In 2014, another Ug99 variant (TTKTT), with one of the most complex virulence profiles, was detected in Kenya. This variant also spread from East Africa to the Middle East, but with only one year between detection in Ethiopia and subsequent detection in Iraq. Here we investigate potential airborne migration routes to account for the rapid spread of TTKTT in East Africa and beyond to the Middle East by using an integrated model combining the outputs from a meteorology-driven fungal spore dispersion model with epidemiological models to account for seasonal availability of susceptible crops and conditions for spore release and infectivity. We find viable pathways in the 2018/19 season that incorporate critical stepping-stone locations in Yemen or Saudi Arabia, but only in the presence of newly irrigated regions in Ethiopia. Our results indicate the potential and increasing importance of irrigated wheat areas in Ethiopia, Yemen and Saudi Arabia for inter-regional stem rust movements. Future movement of stem rust races out of East Africa is considered likely as irrigated areas expand. Targeted surveillance and the use of mitigation strategies including the use of durable resistant varieties in regions of irrigation are required to reduce the risks of enhanced dispersal of stem rust to other regions.
An effective algorithm for deciding the solvability of a system of polynomial equations over 𝑝-adic integers
Authors: Chistov A.
Published: October 2022

Consider a system of polynomial equations in

n
n

variables of degrees at most

d
d

with integer coefficients whose lengths are at most

M
M

. By using a construction close to smooth stratification of algebraic varieties, it is shown that one can construct a positive integer

Δ
>

2

M
(
n
d

)

c

2
n

n
3

\begin{equation*} \Delta > 2^{M(nd)^{c\, 2^n n^3}} \end{equation*}

(here

c
>
0

c>0

is a constant) depending on these polynomials and having the following property. For every prime

p
p

the system under study has a solution in the ring of

p
p

-adic numbers if and only if it has a solution modulo

p
N

p^N

for the least integer

N
N

such that

p
N

p^N

does not divide

Δ
\Delta

. This improves the previously known, at present classical result by B. J. Birch and K. McCann.
Does polypharmacy shape dependency transitions in the very old? Findings from the Newcastle 85+ Study
Authors: Davies Laurie E , Todd Adam , Robinson Louise , Kingston Andrew
Published: October 2022

Background

helping older people to maintain their independence, and identifying risk factors that compromise this, is of high importance. Polypharmacy is common in the very old (aged ≥ 85) but whether it can shape transitions in dependency in this fastest growing subpopulation is unclear.

Methods

using Newcastle 85+ Study data and multi-state modelling, we investigated the association between each additional medication prescribed and the progression of and recovery from dependency states, over 10 years (age 85–95). Participants were defined as either free from care (independent), requiring care less often than daily (low dependency), or requiring care at regular intervals each day or 24 hourly (medium/high dependency).

Results

each additional medication prescribed was associated with a 10% decreased chance of recovery from low dependence to independence (hazard ratio (HR): 0.90, 95% confidence interval (CI): 0.82–0.99).

Discussion

when a relatively able person visits the GP or clinical pharmacist, careful consideration should be given to whether the potential benefits from adding a new medication outweigh the risk to reduced recovery of independence.
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Authors: Wong Ka-Ho , Muddasani Varsha , Peterson Cecilia , Sheibani Nazanin , Arkin Cameron , Cheong Irene , Majersik Jennifer J , Biffi Alessandro , Petersen Nils , Falcone Guido J , Sansing Lauren H , de Havenon Adam H
Published: October 2022

Background

Higher blood pressure variability (BPV) is associated with the development of major vascular diseases, independent of mean blood pressure. However, despite data indicating that serum inflammatory markers are linked to hypertension, the association between serum inflammatory markers and BPV has not been studied in humans.

Methods

This is a post hoc analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) study. The study exposure was tertiles of serum level of interleukin-6 (IL-6), C-reactive protein (CRP), d-dimer, plasmin–antiplasmin complex (PAP), fibrinogen antigen, and calibrated Factor VIII (%) at the baseline study visit. The primary outcome was visit-to-visit BPV measured as the residual standard deviation (rSD) of at least 4 study visits (2000–2018). Two logistic regression models were fit to the top tertile of rSD during follow-up: in Model 1, we adjusted for age, sex, and hypertension, and in Model 2, for patient age categories, sex, race/ethnicity, education, hypertension, diabetes, smoking, drinking, body mass index, lipid-lowering medication, and mean systolic blood pressure.

Results

Our analysis included 5,483 patients, with a mean (SD) age of 61.4 (10.0) years, 52.9% female, and 40.7% White. In unadjusted analyses, all markers of inflammation were associated with higher BPV, but after adjustment, only IL-6 retained significance (P < 0.001). The odds ratio for the highest tertile of BPV and IL-6 was 1.49 (95% confidence interval [CI] 1.28–1.74, P < 0.001).

Conclusions

Baseline serum IL-6 was associated with increased subsequent BPV in a large multiracial cohort. Further investigation is needed to better understand the relationship between chronic inflammation and BPV.
Multifactorial feature extraction and site prognosis model for protein methylation data
Authors: Khandelwal Monika , Kumar Rout Ranjeet , Umer Saiyed , Mallik Saurav , Li Aimin
Published: October 2022

Integrated studies (multi-omics studies) comprising genetic, proteomic and epigenetic data analyses have become an emerging topic in biomedical research. Protein methylation is a posttranslational modification that plays an essential role in various cellular activities. The prediction of methylation sites (arginine and lysine) is vital to understand the molecular processes of protein methylation. However, current experimental techniques used for methylation site predictions are tedious and expensive. Hence, computational techniques for predicting methylation sites in proteins are necessary. For predicting methylation sites, various computational methods have been proposed in recent years. Most existing methods require structural and evolutionary information for retrieving features, acquiring this information is not always convenient. Thus, we proposed a novel method, called multi-factorial feature extraction and site prognosis model (MufeSPM), for the prediction of protein methylation sites based on information theory features (Renyi, Shannon, Havrda–Charvat and Arimoto entropy), amino acid composition and physicochemical properties acquired from protein methylation data. A random forest algorithm was used to predict methylation sites in protein sequences. This paper also studied the impact of different features and classifiers on arginine and lysine methylation data sets. For the R methylation data set, MufeSPM yielded 82.45%($\pm $ 3.47) accuracy, and for the K methylation data set, it provided an average accuracy of 71.94%($\pm $ 2.12). Additionally, the area under the receiver operating characteristic curve for different classifiers in predicting methylation site was provided. The experimental results signify that MufeSPM performs better than the state-of-the-art predictors.
Towards future directions in data-integrative supervised prediction of human aging-related genes
Authors: Li Qi , Newaz Khalique , Milenković Tijana
Published: October 2022

Motivation

Identification of human genes involved in the aging process is critical due to the incidence of many diseases with age. A state-of-the-art approach for this purpose infers a weighted dynamic aging-specific subnetwork by mapping gene expression (GE) levels at different ages onto the protein–protein interaction network (PPIN). Then, it analyzes this subnetwork in a supervised manner by training a predictive model to learn how network topologies of known aging- versus non-aging-related genes change across ages. Finally, it uses the trained model to predict novel aging-related gene candidates. However, the best current subnetwork resulting from this approach still yields suboptimal prediction accuracy. This could be because it was inferred using outdated GE and PPIN data. Here, we evaluate whether analyzing a weighted dynamic aging-specific subnetwork inferred from newer GE and PPIN data improves prediction accuracy upon analyzing the best current subnetwork inferred from outdated data.

Results

Unexpectedly, we find that not to be the case. To understand this, we perform aging-related pathway and Gene Ontology term enrichment analyses. We find that the suboptimal prediction accuracy, regardless of which GE or PPIN data is used, may be caused by the current knowledge about which genes are aging-related being incomplete, or by the current methods for inferring or analyzing an aging-specific subnetwork being unable to capture all of the aging-related knowledge. These findings can potentially guide future directions towards improving supervised prediction of aging-related genes via -omics data integration.

Availability and implementation

All data and code are available at zenodo, DOI: 10.5281/zenodo.6995045.

Supplementary information

Supplementary data are available at Bioinformatics Advances online.
GAVISUNK: genome assembly validation via inter-SUNK distances in Oxford Nanopore reads
Authors: Dishuck Philip C , Rozanski Allison N , Logsdon Glennis A , Porubsky David , Eichler Evan E
Published: October 2022

Motivation

Highly contiguous de novo phased diploid genome assemblies are now feasible for large numbers of species and individuals. Methods are needed to validate assembly accuracy and detect misassemblies with orthologous sequencing data to allow for confident downstream analyses.

Results

We developed GAVISUNK, an open-source pipeline that detects misassemblies and produces a set of reliable regions genome-wide by assessing concordance of distances between unique k-mers in Pacific Biosciences high-fidelity assemblies and raw Oxford Nanopore Technologies reads.

Availability and implementation

GAVISUNK is available at https://github.com/pdishuck/GAVISUNK.

Supplementary information

Supplementary data are available at Bioinformatics online.