bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic Algorithm for Residual Pain After Total Knee Arthroplasty
Authors: Park Caroline N. , White Peter B. , Meftah Morteza , Ranawat Amar S. , Ranawat Chitranjan S.
Published: January 2016

Although total knee arthroplasty is a successful and cost-effective procedure, patient dissatisfaction remains as high as 50%. Postoperative residual knee pain after total knee arthroplasty, with or without crepitation, is a major factor that contributes to patient dissatisfaction. The most common location for residual pain after total knee arthroplasty is anteriorly. Because residual pain has been associated with an un-resurfaced patella, this review includes only registry data and total knee arthroplasty with patella replacement. Some suggest that the pathogenesis of residual knee pain may be related to mechanical stimuli that activate free nerve endings around the patellofemoral joint. Various etiologies have been implicated in residual pain, including (1) low-grade infection, (2) midflexion instability, and (3) component malalignment with patellar maltracking. Less common causes include (4) crepitation and patellar clunk syndrome; (5) patellofemoral symptoms, including overstuffing and avascular necrosis of the patella; (6) early aseptic loosening; (7) hypersensitivity to metal or cement; (8) complex regional pain syndrome; and (9) pseudoaneurysm. Because all of these conditions can lead to residual pain, identifying the etiology can be a difficult diagnostic challenge. Often, patients with persistent pain and normal findings on radiographs and laboratory workup may benefit from a diagnostic injection or further imaging. However, up to 10% to 15% of patients with residual pain may have unexplained pain. This literature review summarizes the findings on the causes of residual pain and presents a diagnostic algorithm to facilitate an accurate diagnosis for residual pain after total knee arthroplasty. [
Orthopedics.
2016; 39(2):e246–e252.]
Objective Monitoring of Corneal Backward Light Scattering After Femtosecond Laser-assisted LASIK
Authors: Savini Giacomo , Huang Jinhai , Lombardo Marco , Serrao Sebastiano , Schiano-Lomoriello Domenico , Venanzio Simona , Ducoli Pietro
Published: January 2016

PURPOSE:

To investigate the changes in corneal backward light scattering, as measured by a rotating Scheimpflug camera with automated corneal densitometry software, in eyes treated with femtosecond laser-assisted LASIK (FS-LASIK).

METHODS:

The cornea was examined preoperatively and postoperatively at 1 day, 1 week, and 1, 3, and 6 months in 23 patients who underwent myopic FS-LASIK. Local analysis of corneal backscatter was performed on four concentric radial zones across a 12-mm diameter (0 to 2, 2 to 6, 6 to 10, and 10 to 12 mm) and at a different corneal depth (anterior 120
µ
m, central and posterior 60
µ
m).

RESULTS:

A statistically significant increase in corneal backward light scattering (
P
< .0001) was detected within the central 10 mm of the anterior cornea. The increase in corneal densitometry was gradually reversed over 6 months. The difference compared to preoperative values was no longer statistically significant at 3 and 6 months after surgery in the central cornea, whereas it remained significant in the mid-peripheral annulus (ranging from 6 to 10 mm), where the flap edge was located.

CONCLUSIONS:

FS-LASIK is followed by an increase in corneal backward light scattering during the early postoperative period that returns to baseline by 3 months. Whereas the increase in corneal densitometry at the flap edge location can be related to a scarring reaction, the explanation for such an increase in the central anterior cornea remains speculative.

[
J Refract Surg.
2016;32(1):20–25.]
Agile Coaches and Champions
Authors: Gandomani Taghi Javdani , Nafchi Mina Ziaei
Published: January 2016

Prevalence of Agile methods in software companies is increasing dramatically. Software companies and teams need to employ these methods to overcome the inherent challenges of traditional methods in software development. However, transitioning to Agile approach is a topic of debate. This is mainly because software companies are facing with many challenges, obstacles, and hindrances when leaving traditional methods and moving to Agile methods, as shown in previous research studies. Conducting a large-scale research study showed that Agile transformation need to be supported by several facilitators and identified its most important facilitators. The main aim of this chapter is to present two hidden facilitators of Agile transition, Agile coaches and Agile champions, which rarely have been taken into consideration. Both of these facilitators directly impress the people involved in the transition. People-intensive nature of Agile methods and critical role of the people in the transition process reflect the importance of these facilitators when a software company doing its transition.
MoBip Project
Authors: Altinpulluk Hakan , Kurubacak Gulsun
Published: January 2016

This study aims to set forth a framework for how the design and scenarios should be handled, and how mHealth ecosystem and Universal Design principles should be used in the designing of an “interactive augmented reality 3-D pop-up book” that can be viewed on mobile devices. This book, which will pursue the goal of increasing university college professors' awareness about students with bipolar disorder, will be the first mHealth study handled in this scope in the literature. In the background section of the study, the authors first elaborate on the rapid advancement of mobile devices, their proliferation and their reflections on mHealth projects in the healthcare sector. Then the authors include mHealth-related applications that raise awareness, the authors analyze the importance of social awareness about mental health, and finally, the authors get to the core of bipolar disorder and present the current situation. Within the scope of this study, the authors construct a theoretical framework that will assume the guiding role in the completion of an interactive 3-D pop-up book.
Relapsing bronchiolitis obliterans organising pneumonia and chronic sarcoidosis in an atopic asthmatic patient
Authors: Carbonelli C. , Roggeri A. , Cavazza A. , Zompatori M. , Zucchi L.
Published: January 2016

Asthma is thought to be a Th2 disease while sarcoidosis is considered a Th1 granulomatous disorder. Organising pneumonia is a histologic pattern of lung injury. When it has no recognisable cause it is defined as cryptogenic organising pneumonia. We herein report the case of a patient with recurrent and steroid sensitive organising pneumonia associated with chronic sarcoidosis in an atopic, moderate persistent asthmatic patient. Each disease has been documented with transbronchial biopsies and recurrence of organising pneumonia was suggested by clinical features and by follow up HRCT which shows distinctive signs even in associated disease. Steroids are the mainstay of therapy for these disorders and especially for the consolidated processes typical of organising pneumonia but prognostic indices for relapse and progression are lacking.
The role of Dietitian in cardiac rehabilitation and prevention
Authors: Agostini Susanna , Biffi Barbara , Brazzo Silvia , Da Vico Letizia , Masini Maria Luisa , Scapolo Marisa
Published: January 2016

Rehabilitation and secondary prevention programs are recognized as an essential part of the overall care of patients with cardiovascular disease. They consist of multidisciplinary strategies aiming at the reduction of modifiable risk factors for cardiovascular disease. Cardiac rehabilitation includes non-pharmacological interventions as: Patients’ evaluation. Nutritional counseling. Risk factors management (serum lipids, blood pressure, weight, diabetes, smoking). Psychosocial interventions. Physical activity and cardiovascular physical training counseling. Their effectiveness in the reduction of mortality through the decrease of risk factors has been proven in the last twenty years. Guidelines on appropriate and well-framed interventions have been released and nutritional interventions have a ringside seat in all programs. During 2007, the Italian Association of Dietitians, ANDID, created a working group of expert dietitians, with the goals of making a review of available scientific literature and of elaborating a Professional Position Papers on the role of Dietitian in cardiac rehabilitation and prevention. This Position Paper retrieves and remarks the available evidence that are important for the dietitians, according to their professional role and their contribution in the management of the topic.
Position ANDID on: The role of Dietitian in cardiac rehabilitation and prevention. A comment
Authors: Fattirolli Francesco
Published: January 2016

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Peripartum Cardiomyopathy
Authors: Raddino Riccardo , Bonadei Ivano , Teli Melissa , Chieppa Federica , Caretta Giorgio , Robba Debora , Zanini Gregoriana , Vizzardi Enrico , Dei Cas Livio
Published: January 2016

which left ventricular dysfunction and symptoms of heart failure occur in the peripartum period in previously healthy women. Incidence of PPCM ranges from 1 in 1300 to 1 in 15,000 pregnancies. The etiology of PPCM is unknown, but viral, autoimmune, and idiopathic causes may contribute. The diagnostic criteria are onset of heart failure in the last month of pregnancy or in the first 5 months postpartum, absence of determinable cause for cardiac failure, and absence of a demonstrable heart disease before the last month of pregnancy. Risk factors for PPCM include advanced maternal age, multiparity, African race, twinning, gestational hypertension, and long-term tocolysis. The clinical presentation of patients with PPCM is similar to that of patients with dilated cardiomyopathy. Echocardiography is central to diagnosis. Early diagnosis and initiation of treatment are essential to optimize pregnancy outcome. Treatment is similar to medical therapy for other forms of dilated cardiomyopathy. About half the patients of PPCM recover without complications. The prognosis is poor in patients with persistent cardiomyopathy. Persistence of disease after 6 months indicates irreversible cardiomyopathy and portends worse survival.
Realidad y educación: un modelo didáctico para la catástrofe del Prestige
Authors: Garcia-Raffi Luis M. , Sánchez-Pérez E.A. , Sopena Novales Mario
Published: January 2016

En este trabajo presentamos un modelo didáctico sencillo para la descripción del movimiento de un vertido de un material líquido menos denso que el agua en el mar. El problema ha sido diseñado según un planteamiento en diferentes niveles, para permitir su uso como herramienta en la enseñanza de ciertos conceptos fundamentales de las matemáticas y la física en la universidad, o incluso en el segundo curso del bachillerato.
Artículo de opinión: Una reflexión sobre el papel del profesor de matemáticas
Authors: Escudero Miquel
Published: January 2016

En este artículo se presenta una reflexión en torno a la labor humanista del profesor de Matemáticas, en la encrucijada de los nuevos tiempos y las sucesivas reformas educativas.
La resolución de problemas como herramienta para la modelización matemática
Authors: Romero Sixto
Published: January 2016

La conexión entre las matemáticas y la realidad que nos rodea se ejecuta por medio de actividades de la resolución de problemas contextualizados en nuestro entorno de vida. No hay que olvidar que la Matemática ha evolucionado a través de la historia a partir del planteamiento y el abordaje de problemas; estos dos procesos, que podemos resumir como resolución de problemas, han impulsado su enorme crecimiento y, lo que es más importante, caracterizan la labor del matemático como tal. Ante una situación problemática real, un resultado numérico no tiene sentido desligado del contexto, es necesario darle sentido teniendo en cuenta las condiciones impuestas por la situación. Pero numerosas investigaciones ponen de manifiesto que los estudiantes se limitan a obtener un resultado numérico que dan como solución sin considerar el contexto (Greer, 1993; Silver, 1992). La modelización matemática se entiende como  el proceso por el cual se interpreta matemáticamente situaciones para tomar algún tipo de decisión lo que implica centrarse en elementos de la situación, sus relaciones, patrones y características, teniendo como producto un modelo en algún nivel de sofisticación con relación al propósito. Siguiendo a Schoenfeld presentaremos algunos ejemplos concretos de situaciones (problemas) desarrolladas con alumnos/as de Secundaria, que bien pueden extrapolarse a alumnos/as de niveles superiores donde se expondrán las diferentes fases y heurísticos por las que debemos pasar cuando nos enfrentamos a un problema. También abordaremos algunas consideraciones teóricas en torno al Aprendizaje Basado en Problemas (ABP) como uno de los métodos de enseñanza-aprendizaje que ha tomado más arraigo en las instituciones de educación superior en los últimos años.
Difract: Un nuevo laboratorio virtual para la modelización matemática de las propiedades de difracción de redes fractales
Authors: Giménez M.H. , Monsoriu J.A. , Giménez F. , Pons A. , Barreiro J.C. , Furlan W.D.
Published: January 2016

En este trabajo presentamos un nuevo laboratorio virtual, Difract, desarrollado con Easy Java Simulations para su uso en cursos de Óptica como una herramienta informática para la modelización matemática de las propiedades de difracción de redes fractales 1D y 2D. Este laboratorio virtual permite a los estudiantes analizar rápida y fácilmente la influencia en el patrón de difracción de Fraunhofer de los diferentes parámetros de construcción de la red fractal. Como ejemplo de aplicación se ha considerado el conjunto fractal de Cantor.
Calculo de volúmenes en modelos remallados de elementos finitos
Authors: Lapuebla-Ferri Andrés , Giménez Fernando , Jiménez A.J. , Monsoriu Juan A. , Pérez del Palomar Amaya
Published: January 2016

El Método de los Elementos Finitos asistido por ordenador es una herramienta muy extendida en ingeniería. En ciertas aplicaciones, se precisa modificar la malla del modelo a lo largo del proceso de simulación, lo que se conoce como remallado. En estos casos, además, suele ser necesario realizar mediciones en el modelo de elementos finitos, como por ejemplo calcular el volumen de ciertas regiones del mismo. Los paquetes comerciales disponibles en la actualidad permiten satisfacer algunas de estas necesidades, aunque adolecen de ciertas limitaciones. En este trabajo se presenta una aplicación desarrollada en el código propio de MatlabQc, que permite el cálculo aproximado del volumen de una región del espacio comprendida entre una malla de elementos finitos cuadriláteros lineales y otra malla topológicamente equivalente a la anterior, esta última obtenida a través de un proceso de remallado.
Modelización de superredes cuánticas con MathematicaQc
Authors: Monsoriu J.A. , Giménez M.H. , Giménez F. , Marín M.J.
Published: January 2016

Las superredes cuánticas son dispositivos nanoestruturados formados por varias capas delgadas de semiconductores distribuidas generalmente de forma periódica. Desde un punto de vista pedagógico, resulta sencillo determinar la dispersión de electrones en estos sistemas aplicando un modelo de pozos de potencial definido por la estructura de la red. De esta forma, los coeficientes de transmisión y reflexión pueden calcularse con fines docentes mediante el uso del Método de las Matrices de Transferencia (MMT). En esta contribución se presenta un sencillo código MMT desarrollado con Mathematica que permite la modelización tanto de redes periódicas como de superredes aperiódicas cuasirregulares con la intención de motivar a los estudiantes de física cuántica mediante el uso de geometrías no convencionales como son los fractales o la sucesión de Fibonacci.
Propuesta didáctica para modelizar evapotranspiración de referencia con redes neuronales artificiales en el aula.
Authors: Martí Pau , Pulido Calvo Inmaculada , Gutiérrez Estrada Juan Carlos
Published: January 2016

Las redes neuronales artificiales constituyen una buena alternativa a los modelos convencionales para estimar diferentes variables en ingeniería del riego, entre ellas la evapotranspiración de referencia, clave en la determinación de las necesidades de agua de riego. En este artículo se presenta una metodología didáctica para introducir al alumno en la aplicación de redes neuronales para el cálculo de evapotranspiración de referencia mediante el programa MATLAB©.
Además de aprender a usar esta herramienta en una aplicación concreta dentro de su campo de competencias profesionales futuras, el alumno toma contacto con líneas actuales de investigación en el campo de la ingeniería del riego y se promueven eventuales colaboraciones de investigación.
Nuevos documentos inéditos y desconocidos de Rubén Darío: sobre "La Isla de Oro", el "Poema del Otoño" y los años de "Mundial"
Authors: Martínez José María
Published: January 2016

En este artículo se comenta y reproduce en parte un lote de documentos que incluye unos textos manuscritos y mecanografiados de casi segura autoría dariana y otros de autenticidad más dudosa. Este lote, cuyo origen parece estar en los años de Mundial (1912-1914), además de contener algunos poemas inéditos, incluye otros textos que mostrarían la cooperación entre Darío y sus secretarios o colaboradores en la preparación de los originales inmediatamente antes de ser enviados a la imprenta.
Alegoría: su pertinencia en la predicación y uso en "La novena maravilla"
Authors: Sabena Julia
Published: January 2016

En este artículo se focaliza el recurso de la alegoría como método exegético en la composición de los sermones panegíricos de Juan Espinosa Medrano (Perú, siglo XVII). Se traza el recorrido de la alegoría (y las humanidades en general) en relación –siempre tensa– con el cristianismo a lo largo de su historia; y se llega a la Contrarreforma y el uso exacerbado del método en la predicación barroca; particularmente en la oratoria sagrada de Espinosa Medrano, quien abarca elementos diversos y extraídos de distintas fuentes (filosofía natural, mitología clásica, tradición emblemática, relatos bíblicos), a los que hace funcionar como signos de otra verdad mayor, la sagrada. Si bien las preceptivas sagradas impulsaban una predicación más llana y simple, la profusión de alegorías mitológicas, que el autor resemantiza según su interés de guiar la interpretación, pueden explicarse por varias circunstancias, motivos de estudio en este trabajo.
Libros: Inteligencia
Authors: Argueta José Aurelio
Published: January 2016

Revista Policía y Seguridad Pública 5(2) 2015: 521-523
Libros: La Santa Biblia Nueva Versión Internacional Libro: Josué (Antiguo Testamento) Capítulos: 2 (Rajab y los espías) y 6 (La conquista de Jericó) Páginas: 294- 296 y 299- 300
Authors: Morales Peña Juan Carlos
Published: January 2016

Revista Policía y Seguridad Pública 5(2) 2015: 531-534
 
The Relationship between Dimensions of Health Related Quality of Life and Health Conditions among Elderly People: A Fuzzy Linear Regression Approach
Authors: Abdullah Lazim , Jamalina Mohd Jamal Noor
Published: January 2016

Health Related Quality of Life (HRQoL) is one of the escalating subjects used for assessing health condition among patients who suffer specific diseases or ailments. It has been known that dimensions of HRQoL are able to mirror one’s overall health condition using mainly standard statistical technique. However, devising the extent of contribution of multiple dimensions towards overall health conditions is not straight forward as the arbitrary nature of HRQoL dimensions. Therefore this paper aims to propose a model to explain the relationship between HRQoL dimensions and overall health condition using a matrix driven fuzzy linear regression. An experiment was conducted to measure the strength of the relationship among elderly people via judgment provided by ten decision makers. The health condition linguistic data and scaled data of regularity of experiencing health-related problems among elderly people were given by the decision makers. The five stepwise computations based on matrix-driven fuzzy linear regression were proposed to describe the relationship. It is found that nearly forty six percent variations in overall health condition of elder people were explained by the eights HRQoL dimensions. The employment of matrix-driven multivariate fuzzy linear regression model has successfully identified the strength of the relationship between multi dimensions of HRQoL and overall health condition in the case of elderly people.
Des écrins ciselés pour un orfèvre du son : rencontre entre l’univers graphique de Heung-Heung Chin (Chippy) et la musique de John Zorn
Authors: Brunel-Lafargue Karen
Published: January 2016

Cet article entend décrypter quelques réalisations du duo Heung-Heung Chin, alias Chippy, la designer graphique de Tzadik, et John Zorn, le musicien, compositeur et fondateur de la célèbre maison de disques. Tous deux croient au rôle déterminant du disque – à la fois comme support physique et vecteur esthétique – dans l’expérience musicale. L’esprit d’expérimentation caractéristique de la philosophie de Zorn trouve écho dans l’approche graphique de Chippy. La collection Archival Series, dédiée à l’oeuvre de Zorn, ne propose pas des supports musicaux banalement emballés, mais plutôt des objets multisensoriels – à écouter, à toucher, à lire et à contempler. L’écrin est inscrit dans la continuité conceptuelle et esthétique du contenu. Après le récit du parcours de la graphiste, de sa rencontre avec Zorn et de leur collaboration débutée il y a maintenant plus de 15 ans, nous procédons à une analyse graphique de quelques albums de cette collection.
Bias in streamflow projections due to climate‐induced shifts in catchment response
Authors: Saft Margarita , Peel Murray C. , Western Andrew W. , Perraud Jean‐Michel , Zhang Lu
Published: January 2016

Demand for quantitative assessments of likely climate change impact on runoff is increasing and conceptual rainfall‐runoff models are essential tools for this task. However, the capacity of these models to extrapolate under changing climatic conditions is questionable. A number of studies have found that model predictive skill decreases with changed climatic conditions, especially when predicting drier climates. We found that model skill only declines under certain circumstances, in particular, when a catchment's rainfall‐runoff processes change due to changed climatic drivers. In catchments where the rainfall‐runoff relationship changed significantly in response to prolonged dry conditions, runoff was consistently overestimated. In contrast, modeled runoff was unbiased in catchments where the rainfall‐runoff relationship remained unchanged during the dry period. These conclusions were not model dependent. Our results suggest that current projections of runoff under climate change may provide overly optimistic assessments of future water availability in some regions expecting rainfall reductions.
Direct Use of Benzylic Alcohols for Gold(III)‐Catalyzed S‐Benzylation of Mercaptobenzoic Acids in Water
Authors: Hikawa Hidemasa , Tada Ayaka , Kikkawa Shoko , Azumaya Isao
Published: January 2016

We demonstrate the gold(III)‐catalyzed direct substitution of benzylic alcohols in water. These atom economic and environmentally benign protocols afford S‐benzylated products in moderate to excellent yields. In contrast, common Lewis or Brønsted acids as catalyst, and organic solvents such as dichloromethane or toluene were ineffective for the S‐benzylation of mercaptobenzoic acids. Water can be an attractive tool for new transition metal‐catalyzed reactions. A Hammett study for the rate constants with various substituted alcohols shows a good correlation (R2=0.97) between the log(kX/kH) and the σ+ value of the respective substituents. From the slope negative ρ values of 2.35 are obtained, suggesting that there is a build‐up of positive charge in the transition state. Our catalytic system can be performed with the use of only 2 mol% of gold(III) catalyst without any other additives in water, and scaled up to 10 mmol scale (85% isolated yield). Notably, the present method can accomplish the S‐benzylation of unprotected mercaptobenzoic acids, which is chemoselective and leaves the carboxyl group intact. Furthermore, the direct substitution of allylic and propargylic alcohols also proceeded smoothly in good yields.

magnified image
Prediction of variety distinctness decisions under yearly heterogeneity
Authors: ROBERTS A. M. I. , NEVISON I. M. , CHRISTIE T.
Published: January 2016

To gain protection under the International Convention for the Protection of New Varieties of Plant, new plant varieties must be distinguishable from existing varieties in at least one important characteristic. Assessment of quantitative characteristics often uses a procedure based on analysis of variance of variety-by-year means for 2 years of trials. In the current paper, a new method is described that can identify those reference varieties that are so different from a candidate that there would be no reason to compare them in the subsequent year, resulting in potential cost savings. It is more objective and transparent than existing practice for quantitative characteristics based on expert opinion. The method calculates thresholds for quantitative characteristics. The thresholds are defined so that if in the first year the difference between two varieties in a characteristic is larger than the characteristic's threshold then it is highly likely that the varieties would be distinct after 2 years. Thresholds were derived based on statistical predictions of the full decision after 2 years using the first year results combined with historical data. It is shown that these thresholds are sensitive to yearly heterogeneity in the variety-by-year variation. The method accommodates this heterogeneity by modelling yearly residual variances with the inverse gamma distribution. This extension meant that exact analytical formulae were not available so an approximation was suggested. Using simulation it was found that the approximation was reasonable; for thresholds corresponding to a high probability of distinctness, the approximate thresholds were a little higher than required. The method was evaluated on a 19-year data set for field pea, comparing decisions based on first year thresholds with those based on the full 2 years. It was found that with the probability of distinctness set at 0·99, the calculated thresholds were generally lower than the existing expert-set thresholds but had acceptable levels of false positives and false negatives.
Rapid effects of deep brain stimulation reactivation on symptoms and neuroendocrine parameters in obsessive-compulsive disorder
Authors: de Koning P P , Figee M , Endert E , van den Munckhof P , Schuurman P R , Storosum J G , Denys D , Fliers E
Published: January 2016

Improvement of obsessions and compulsions by deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) is often preceded by a rapid and transient mood elevation (hypomania). In a previous study we showed that improvement of mood by DBS for OCD is associated with a decreased activity of the hypothalamus–pituitary adrenal axis. The aim of our present study was to evaluate the time course of rapid clinical changes following DBS reactivation in more detail and to assess their association with additional neuroendocrine parameters. We included therapy-refractory OCD patients treated with DBS (>1 year) and performed a baseline assessment of symptoms, as well as plasma concentrations of thyroid-stimulating hormone (TSH), prolactin, growth hormone, copeptin and homovanillic acid. This was repeated after a 1-week DBS OFF condition. Next, we assessed the rapid effects of DBS reactivation by measuring psychiatric symptom changes using visual analog scales as well as repeated neuroendocrine measures after 30 min, 2 h and 6 h. OCD, anxiety and depressive symptoms markedly increased during the 1-week OFF condition and decreased again to a similar extent already 2 h after DBS reactivation. We found lower plasma prolactin (41% decrease, P=0.003) and TSH (39% decrease, P=0.003) levels during DBS OFF, which increased significantly already 30 min after DBS reactivation. The rapid and simultaneous increase in TSH and prolactin is likely to result from stimulation of hypothalamic thyrotropin-releasing hormone (TRH), which may underlie the commonly observed transient mood elevation following DBS.
Accurate biometal quantification per individual Caenorhabditis elegans
Authors: Ganio Katherine , James Simon A. , Hare Dominic J. , Roberts Blaine R. , McColl Gawain
Published: January 2016

A comparison of complementary methods to quantify biometals per individual for analytical biochemical studies using microscopic model organisms.
Printed microelectrodes for scalable, high-areal-capacity lithium–sulfur batteries
Authors: Milroy Craig , Manthiram Arumugam
Published: January 2016

Freestanding, printed microelectrodes for lithium–sulfur cathodes with high areal capacity are produced with a high-precision dispenser.
Control of interpenetration in a microporous metal–organic framework for significantly enhanced C2H2/CO2separation at room temperature
Authors: Chang Ganggang , Li Bin , Wang Hailong , Hu Tongliang , Bao Zongbi , Chen Banglin
Published: January 2016

A novel non-interpenetrated three-dimensional porous metal–organic framework UTSA-68 has been controllably synthesized by altering the reaction conditions.
NO2-induced performance enhancement of PEDOT:PSS/Si hybrid solar cells with a high efficiency of 13.44%
Authors: Yang Pu , Xie Dan , Zhao Yuanfan , Xu Jianlong , Li Xinming , Teng Changjiu , Sun Yilin , Li Xian , Zhu Hongwei
Published: January 2016

Using poly(3,4-ethylene-dioxythiophene): poly(styrene-sulfonate) (PEDOT:PSS) as an hole layer, high power conversion efficiency (PCE) of 12.13% and the mechanism of enhancement are obtained.
Two-bit memory and quantized storage phenomenon in conventional MOS structures with double-stacked Pt-NCs in an HfAlO matrix
Authors: Zhou Guangdong , Wu Bo , Liu Xiaoqin , Li Ping , Zhang Shuangju , Sun Bai , Zhou Ankun
Published: January 2016

Two-bit memory and quantized storage phenomenon based on double-stacked Pt-NCs in an HfAlO matrix.
Synthesis, characterization and enhanced photocatalytic CO2 reduction activity of graphene supported TiO2 nanocrystals with coexposed {001} and {101} facets
Authors: Xiong Zhuo , Luo Ying , Zhao Yongchun , Zhang Junying , Zheng Chuguang , Wu Jeffrey C. S.
Published: January 2016

Enhanced CO2 photoreduction over graphene supported TiO2 nanocrystals with co-exposed {001} and {101} facets.
The stacking dependent electronic structure and optical properties of bilayer black phosphorus
Authors: Shu Huabing , Li Yunhai , Niu Xianghong , Wang Jinlan
Published: January 2016

The optical excitations of bilayer black phosphorus with four different stacking patterns.
A microfluidic opto-caloric switch for sorting of particles by using 3D-hydrodynamic focusing based on SLE fabrication capabilities
Authors: Meineke G. , Hermans M. , Klos J. , Lenenbach A. , Noll R.
Published: January 2016

In a miniaturised flow switch fluid flows are controlled by reducing the local viscosity via absorption of laser radiation. The microfluidic chip is fabricated using Selective Laser-Induced Etching (SLE).
Reaction rate constant for radiative association of CF+
Authors: Öström Jonatan , Bezrukov Dmitry S. , Nyman Gunnar , Gustafsson Magnus
Published: January 2016

Reaction rate constants and cross sections are computed for the radiative association of carbon cations (C+) and fluorine atoms (F) in their ground states. We consider reactions through the electronic transition 11Π → X1Σ+ and rovibrational transitions on the X1Σ+ and a3Π potentials. Semiclassical and classical methods are used for the direct contribution and Breit–Wigner theory for the resonance contribution. Quantum mechanical perturbation theory is used for comparison. A modified formulation of the classical method applicable to permanent dipoles of unequally charged reactants is implemented. The total rate constant is fitted to the Arrhenius–Kooij formula in five temperature intervals with a relative difference of <3%. The fit parameters will be added to the online database KIDA. For a temperature of 10–250 K, the rate constant is about 10−21 cm3 s−1, rising toward 10−16 cm3 s−1 for a temperature of 30 000 K.
Particle-in-cell δf gyrokinetic simulations of the microtearing mode
Authors: Chowdhury J. , Chen Yang , Wan Weigang , Parker Scott E. , Guttenfelder W. , Canik J. M.
Published: January 2016

The linear stability properties of the microtearing mode are investigated in the edge and core regimes of the National Spherical Torus Experiment (NSTX) using the particle-in-cell method based gyrokinetic code GEM. The dependence of the mode on various equilibrium quantities in both regions is compared. While the microtearing mode in the core depends upon the electron-ion collisions, in the edge region, it is found to be weakly dependent on the collisions and exists even when the collision frequency is zero. The electrostatic potential is non-negligible in each of the cases. It plays opposite roles in the core and edge of NSTX. While the microtearing mode is partially stabilized by the electrostatic potential in the core, it has substantial destabilizing effect in the edge. In addition to the spherical tokamak, we also study the microtearing mode for parameters relevant to the core of a standard tokamak. The fundamental characteristics of the mode remain the same; however, the electrostatic potential in this case is destabilizing as opposed to the core of NSTX. The velocity dependence of the collision frequency, which is crucial for the mode to grow in slab calculations, is not required to destabilize the mode in toroidal devices.
Whittaker functions in beam driven plasma wakefield acceleration for a plasma with a parabolic density profile
Authors: Golian Y. , Aslaninejad M. , Dorranian D.
Published: January 2016

A model for the interaction of charged particle beams and plasma for a linear wakefield generation in a parabolic plasma channel is presented. The density profile has the maximum on the axis. A Gaussian proton beam is employed to excite the plasma wakefield in the channel. We have built a thorough analytical model and solved the governing equations for the wakefield acceleration of a charged particle beam. The longitudinal and radial wakefields are expressed by Whittaker functions, and for certain parameters of plasma and the beam, their behaviours in longitudinal and radial directions are investigated. It is observed that the radial electric field generated by the bunch increases with the distance behind the bunch.
Reentrant spin-glass behavior and bipolar exchange-bias effect in “Sn” substituted cobalt-orthotitanate
Authors: Nayak S. , Joshi D. C. , Krautz M. , Waske A. , Eckert J. , Thota S.
Published: January 2016

We report the co-existence of longitudinal ferrimagnetic behavior with Néel temperature TN ∼ 46.1 K and reentrant transverse spin-glass state at 44.05 K in Tin (Sn) doped cobalt-orthotitanate (Co2TiO4). The ferrimagnetic ordering is resulting from different magnetic moments of Co2+ on the A-sites (3.87 μB) and B-sites (5.069 μB). The magnetic compensation temperature (TCOMP) shifts from 31.74 K to 27.1 K when 40 at. % of “Sn4+” substitutes “Ti4+” at B-sites where the bulk-magnetization of two-sublattices balance each other. For T > TN, the dc-magnetic susceptibility (χdc = M/Hdc) fits well with the Néel's expression for the two-sublattice model with antiferromagnetic molecular field constants NBB ∼ 15.44, NAB ∼ 32.01, and NAA ∼ 20.88. The frequency dependence of ac-magnetic susceptibility χac data follows the Vogel-Fulcher law, and the power-law of critical slowing-down with “zν” = 6.01 suggests the existence of spin-clusters (where “z” and “ν” being dynamic critical-exponent and correlation length of critical-exponent, respectively). This system exhibits unusual hysteresis loops with large bipolar exchange-bias effect (HEB ∼ 13.6 kOe at 7 K) after zero-field cooling process from an un-magnetized state, and a dramatic collapse of remanence (MR) and coercive field (HC) across TCOMP. The possible origins of such anomalous characteristics were discussed.
Strictly monolayer large continuous MoS2 films on diverse substrates and their luminescence properties
Authors: Mohapatra P. K. , Deb S. , Singh B. P. , Vasa P. , Dhar S.
Published: January 2016

Despite a tremendous interest on molybdenum disulfide as a thinnest direct band gap semiconductor, single step synthesis of a large area purely monolayer MoS2 film has not yet been reported. Here, we report a CVD route to synthesize a continuous film of strictly monolayer MoS2 covering an area as large as a few cm2 on a variety of different substrates without using any seeding material or any elaborate pretreatment of the substrate. This is achieved by allowing the growth to take place in the naturally formed gap between a piece of SiO2 coated Si wafer and the substrate, when the latter is placed on top of the former inside a CVD reactor. We propose a qualitative model to explain why the MoS2 films are always strictly monolayer in this method. The photoluminescence study of these monolayers shows the characteristic excitonic and trionic features associated with monolayer MoS2. In addition, a broad defect related luminescence band appears at ∼1.7 eV. As temperature decreases, the intensity of this broad feature increases, while the band edge luminescence reduces.
Optical characteristics for capacitively and inductively radio frequency discharge and post-discharge of helium
Authors: Tanışlı Murat , Şahin Neslihan
Published: January 2016

The optical properties for radiofrequency (RF) post-discharge of pure helium (He) with two different methods as capacitively and inductively have been presented using the modified Boltzmann method in comparison. Optical emission spectroscopy (OES) is often used in the diagnosis of laboratory plasma, such as gas discharge plasma. OES is a very useful method for calculating of the electron temperature in the plasma and the determination of different atoms and molecules. In this study, OES is applied for characterizations of capacitively and inductively RF He plasma at pressures between 0.62 and 2.2 mbar for newly reactor type. Plasmas are generated with an RF power generator at a frequency of 13.56 MHz and output powers of 100, 160, and 200 W. Spectra have been evaluated in the range 200–1200 nm by an optical spectrometer. At low pressure, the main spectral features reported are the wavelengths of the atomic He transitions at 388.87 and 728.13 nm. The atomic emission intensities showed a maximum in inductive system when the pressure is about 0.62 mbar. OES of capacitive discharge and inductive discharge is compared in detail. The transition for 587.56 nm is shown to be increased in time.
Enhanced emission and photoconductivity due to photo-induced charge transfer from Au nanoislands to ZnO
Authors: Wu Shang-Hsuan , Chan Ching-Hsiang , Chien Ching-Hang , Yaseen Mohammad Tariq , Liang Ching-Tarng , Chang Yia-Chung
Published: January 2016

We report systematic studies based on photoluminescence, Hall, and photoconductivity measurements together with theoretical modeling in order to identify mechanisms for the photo-induced charge transfer effects in ZnO thin film incorporated with the Au nano-islands (AuNIs). Significant enhancement of near band edge emission and improvement in conductivity of ZnO/AuNIs samples after illumination are observed, which are attributed to the photo-induced hot electrons in Au which are then transferred into the conduction band of ZnO as long as the excitation energy is higher than the offset between the ZnO conduction-band minimum and Au Fermi level. Our experimental results are consistent with the general features predicted by first principles calculations.
Highly functionalized organic nitrates in the southeast United States: Contribution to secondary organic aerosol and reactive nitrogen budgets
Authors: Lee Ben H. , Mohr Claudia , Lopez-Hilfiker Felipe D. , Lutz Anna , Hallquist Mattias , Lee Lance , Romer Paul , Cohen Ronald C. , Iyer Siddharth , Kurtén Theo , Hu Weiwei , Day Douglas A. , Campuzano-Jost Pedro , Jimenez Jose L. , Xu Lu , Ng Nga Lee , Guo Hongyu , Weber Rodney J. , Wild Robert J. , Brown Steven S. , Koss Abigail , de Gouw Joost , Olson Kevin , Goldstein Allen H. , Seco Roger , Kim Saewung , McAvey Kevin , Shepson Paul B. , Starn Tim , Baumann Karsten , Edgerton Eric S. , Liu Jiumeng , Shilling John E. , Miller David O. , Brune William , Schobesberger Siegfried , D'Ambro Emma L. , Thornton Joel A.
Published: January 2016

Significance

We present online field observations of the speciated molecular composition of organic nitrates in ambient atmospheric particles utilizing recently developed high-resolution MS-based instrumentation. We find that never-before-identified low-volatility organic species, which are highly functionalized, explain a major fraction of the total particle nitrate mass measured by the traditional aerosol mass spectrometer. An observationally constrained box model shows that these organic nitrates are likely derived from oxidation of biogenic hydrocarbons and persist in the particle phase for only a few hours. Given their high rate of loss, their fates have significant implications for the budgets of secondary organic aerosol particles and nitrogen oxides but are currently unknown.
Near-linear response of mean monsoon strength to a broad range of radiative forcings
Authors: Boos William R. , Storelvmo Trude
Published: January 2016

Significance

Previous studies have argued that monsoons, which are continental-scale atmospheric circulations that deliver water to billions of people, will abruptly shut down when aerosol emissions, land use change, or greenhouse gas concentrations reach a critical threshold. Here it is shown that the theory used to predict such “tipping points” omits a dominant term in the equations of motion, and that both a corrected theory and an ensemble of global climate model simulations exhibit no abrupt shift in monsoon strength in response to large changes in various forcings. Therefore, although monsoons are expected to change in response to anthropogenic forcings, there is no reason to expect an abrupt shift into a dry regime in the next century or two.
Cryptochrome 2 mediates directional magnetoreception in cockroaches
Authors: Bazalova Olga , Kvicalova Marketa , Valkova Tereza , Slaby Pavel , Bartos Premysl , Netusil Radek , Tomanova Katerina , Braeunig Peter , Lee How-Jing , Sauman Ivo , Damulewicz Milena , Provaznik Jan , Pokorny Richard , Dolezel David , Vacha Martin
Published: January 2016

Significance

The photosensitive protein Cryptochrome (Cry) is involved in the detection of magnetic fields (MFs) inDrosophila. However, Cry-dependent responses to natural MF intensities and to the direction of the MF vector have not been demonstrated previously in any insect. Birds, monarch butterflies, and many other species perceive the direction of geomagnetic field (GMF) lines, but the involvement of Cry has not been rigorously proven using genetic tools. In this study, by combining behavioral and genetic approaches, we provide the first unambiguous evidence to our knowledge of a Cry-dependent sensitivity to the direction of GMF in two cockroach species. Furthermore, by eye-covering experiments and by immunolocalization of a crucial mammalian-type Cry2 under the retina, we clearly show that the eye is an indispensable organ for the directional GMF response.
Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets
Authors: Ryan John F. , Hovde Rachel , Glanville Jacob , Lyu Shu-Chen , Ji Xuhuai , Gupta Sheena , Tibshirani Robert J. , Jay David C. , Boyd Scott D. , Chinthrajah R. Sharon , Davis Mark M. , Galli Stephen J. , Maecker Holden T. , Nadeau Kari C.
Published: January 2016

Significance

The mechanisms through which successful immunotherapy induces possible deletion, replacement, or reprogramming of T cells are unknown. By evaluating the expression of T-cell–related genes, and using appropriate multivariate statistical approaches, our data show that successful immunotherapy can induce previously unidentified CD4+ T-cell subtypes during treatment that could help to predict an “immune-tolerant” clinical phenotype identified after cessation of treatment. The ability to use “anergic” transcriptional phenotypes in single T cells to predict successful “immune tolerance” induction in the clinic setting, as suggested by our findings, could lead to transformative impacts in the field of immunotherapy.
Biogeography of a human oral microbiome at the micron scale
Authors: Mark Welch Jessica L. , Rossetti Blair J. , Rieken Christopher W. , Dewhirst Floyd E. , Borisy Gary G.
Published: January 2016

Significance

The physiology and ecology of complex microbial communities are strongly dependent on the immediate surroundings of each microbe, including the identity of neighboring microbes; however, information on the micron-scale organization of microbiomes is largely lacking. Using sequencing data combined with spectral fluorescence imaging, we have discovered a multigenus, highly organized microbial consortium in human dental plaque. The spatial structure of the consortium reveals unanticipated interactions and provides a framework for understanding the organization, metabolism, and systems biology of the microbiome and ultimately, its effect on the health of the human host. Our synthesis of high-throughput sequencing data with spatial and structural information shows the informative value of microbial biogeography at the micron scale.
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Authors: Moudry Pavel , Watanabe Kenji , Wolanin Kamila M. , Bartkova Jirina , Wassing Isabel E. , Watanabe Sugiko , Strauss Robert , Troelsgaard Pedersen Rune , Oestergaard Vibe H. , Lisby Michael , Andújar-Sánchez Miguel , Maya-Mendoza Apolinar , Esashi Fumiko , Lukas Jiri , Bartek Jiri
Published: January 2016

Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear. Here, through an unbiased small interfering RNA screen, we identified and validated TOPBP1 as a novel determinant whose loss sensitized human cells to olaparib, an inhibitor of poly(ADP-ribose) polymerase. We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberrant patterns in subsets of human ovarian carcinomas. TOPBP1 depletion abrogated RAD51 loading to chromatin and formation of RAD51 foci, but without affecting the upstream HR steps of DNA end resection and RPA loading. Furthermore, TOPBP1 BRCT domains 7/8 are essential for RAD51 foci formation. Mechanistically, TOPBP1 physically binds PLK1 and promotes PLK1 kinase–mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin. Overall, our results provide mechanistic insights into TOPBP1’s role in HR, with potential clinical implications for cancer treatment.
Once the Internet can measure itself
Authors: Kirkpatrick Scott
Published: January 2016

In communications, the obstacle to high bandwidth and reliable transmission is usually the interconnections, not the links. Nowhere is this more evident than on the Internet, where broadband connections to homes, offices and now mobile smart phones are a frequent source of frustration, and the interconnections between the roughly 50 000 subnetworks (autonomous systems or ASes) from which it is formed, even more so. The structure of the AS graph that is formed by these interconnections is unspecified, undocumented and only guessed-at through measurement, but it shows surprising efficiencies. Under recent pressures for network neutrality and openness or ‘transparency’, operators, several classes of users and regulatory bodies have a good chance of realizing these efficiencies, but they need improved measurement technology to manage this under continued growth. A long-standing vision, an Internet that measures itself, in which every intelligent port takes a part in monitoring, can make this possible and may now be within reach.