bluuebunny/crossref_metadata_2025 huggingface dataset:
Tanshinone IIA attenuates valvular interstitial cells’ calcification induced by oxidized low density lipoprotein via reducing endoplasmic reticulum stress
Authors: Chen Fang , Yang Dongqiang , Ru Yuhua , Bai Yu , Pei Xueliang , Sun Jie , Cao Shan , Wang Weiguang , Gao Aishe
Published: September 2023

Recent studies revealed that endoplasmic reticulum (ER) stress played an emerging role of in valve calcification. Tanshinone IIA (TanIIA) has been a research hotspot in cardiovascular diseases. Previously we found that sodium TanIIA dampened the pathological phenotype transition of valvular interstitial cells (VICs) by affecting ER stress published in Chinese Journal. Here, we test the hypothesis that TanIIA attenuates the pro-osteogenic effects of oxidized low-density lipoprotein (oxLDL) in VICs by reducing induction of ER stress. Patients’ aortic valve (AV) was collected, and porcine VICs were cultured for in vitro model. ER stress markers were tested in human leaflets by immunostaining. Immunoblotting were used to test the osteoblastic factors such as Runx2, osteocalcin, and ER stress markers GRP78, CHOP, XBP1, etc. Alkakine phosphate (ALP) activity assay were used to test the activity of ALP kinase. Pro-inflammatory gene expression was detected by polymerase chain reaction. As a result, ER stress markers were elevated in patients’ calcified AVs. OxLDL induced osteogenesis and inflammation via promoting ER stress. TanIIA attenuated oxLDL induced ER stress. TanIIA also inhibited theosteoblastic factors and inflammatory cytokine expressions in VICs. In conclusion, our data provide evidence that TanIIA exerts anti-inflammation and anti-osteogenic effects in VICs by attenuating ER stress, and ER stress acts as an important regulator in oxLDL induced VICs’ phenotype transition.
AS-IV enhances the antitumor effects of propofol in NSCLC cells by inhibiting autophagy
Authors: Liu Jintao , Chen Long , Zhang Jialing , Luo Xiaopan , Tan Yingyi , Qian Shaojie
Published: September 2023

Non-small cell lung cancer (NSCLC) is one of the most lethal malignant tumors. It has been shown that the general anesthetic agents, propofol and astragaloside IV (AS-IV) both exert antitumor effects in NSCLC. However, the effects of the combination of propofol with AS-IV in NSCLC remain unclear. Cell counting kit-8, and EdU and Transwell assays were performed to evaluate NSCLC cell viability, proliferation, and migration. Cell apoptosis and autophagy were observed by flow cytometric analysis and TUNEL and LC3 staining, respectively. AS-IV notably enhanced the anti-proliferative, pro-apoptotic, and anti-migratory properties of propofol in NSCLC cells. Moreover, AS-IV remarkably facilitated the anti-autophagy effect of propofol in NSCLC cells by downregulating LC3, Beclin 1, and ATG5. Significantly, the pro-apoptotic ability of the AS-IV/propofol combination in NSCLC cells was further enhanced by the autophagy inhibitor 3-MA, suggesting that autophagy plays a tumor-promoting role in NSCLC cells. Collectively, AS-IV could facilitate the antitumor abilities of propofol in NSCLC cells by inhibiting autophagy. These findings may be beneficial for future studies on the use of AS-IV and propofol for the treatment of NSCLC.
The Tuvan Shamanism and Its Features
Authors: Burged Munkhtsetseg
Published: September 2023

We aim to study the tuvan shamansm and to reveal its specific features of shamanism of the Tuvan ethnic group in Mongolia and collected materials for our study during field work by interviewing, taking pictures, video and audio records. As an expected result of our study, we come to gain essential knowledge and records on ethnolinguistic, cultural issues, customs, and current status of religion /shamanism/ for the ethnic minority. The tuvans still retain such important components of ethnicity as their native language, their ancient religion-shamanism, and some features of their traditional culture, which identify them as Tuvans. Today the Tuvan shamanism has been studied less than those of the other ethnic groups in Mongolia. Many researchers have studied the Tuvan shamanism as it has been keeping its nature and shamanic rituals for the centuries as if their ancestors did. By studying the tuvan shamansm, researchers and other people gain a deeper understanding the culture and language of the ethnic minority – tuvans living in different parts of Mongolia and speak the Tuvan language as their native tongue.
Nanoantenna induced liquid crystal alignment for high performance tunable metasurface
Authors: Maruthiyodan Veetil Rasna , Xu Xuewu , Dontabhaktuni Jayasri , Liang Xinan , Kuznetsov Arseniy I. , Paniagua-Dominguez Ramon
Published: September 2023

Liquid crystal (LC) based spatial light modulators (SLMs) are a type of versatile device capable of arbitrarily reconfiguring the wavefront of light. For current commercial LC-SLM devices, the large pixel size limits their application to diffractive optics and 3D holographic displays. Pixel miniaturization of these devices is challenging due to emerging inter-pixel crosstalk, ultimately linked to the thick LC layer necessary for full phase (or amplitude) control. Integration of metasurfaces, i.e., 2D arrangements of resonant nanoantennas, with thin LC has emerged as a promising platform to boost light modulation, enabling realization of sub-wavelength pixel size SLMs with full phase (or amplitude) control. In most devices realized so far, however, the presence of an alignment layer, necessary to induce a preferential initial LC orientation, increases the voltage requirement for resonance tuning and reduces the efficiency of light modulation, something that accentuates for an ultra-thin (e.g., submicron) metasurface-LC cell. Here, we present an alternative strategy by which the LC molecular alignment is purely controlled by the periodicity and geometry of the nanoantenna without any additional alignment layer. The nanoantennas are specifically designed for the double purpose of sustaining optical resonances that are used for light modulation and to, simultaneously, induce the required LC pre-alignment. The proposed device structure allows lower voltage and reduced switching times (sub-millisecond) compared to devices including the alignment layer. This novel strategy thus helps to improve the performance of these miniaturized-pixel devices, which have emerged as one of the potential candidates for the next generation of products in a wide range of applications, from virtual/augmented reality (VR/AR) and solid-state light detection and ranging (LiDAR), to 3D holographic displays and beyond.
Walks and eigenvalues of signed graphs
Authors: Stanić Zoran
Published: September 2023

In this article, we consider the relationships between walks in a signed graph

G

˙

\dot{G}

and its eigenvalues, with a particular focus on the largest absolute value of its eigenvalues

ρ

(

G

˙

)

\rho \left(\dot{G})

, known as the spectral radius. Among other results, we derive a sequence of lower bounds for

ρ

(

G

˙

)

\rho \left(\dot{G})

expressed in terms of walks or closed walks. We also prove that

ρ

(

G

˙

)

\rho \left(\dot{G})

attains the spectral radius of the underlying graph

G

G

if and only if

G

˙

\dot{G}

is switching equivalent to

G

G

or its negation. It is proved that the length

k

k

of the shortest negative cycle in

G

˙

\dot{G}

and the number of such cycles are determined by the spectrum of

G

˙

\dot{G}

and the spectrum of

G

G

. Finally, a relation between

k

k

and characteristic polynomials of

G

˙

\dot{G}

and

G

G

is established.
Editorial
Authors: Wagner Gustavo Peretti Wagner , Cerqueira Fábio Vergara Cerqueira , Guedes Milheira Rafael
Published: September 2023

.
O ENSINO BILÍNGUE DE SURDOS SOB A PERSPECTIVA DA TRANSLINGUAGEM
Authors: Bernardino Elidéa , Da Cunha Pereira Maria Cristina
Published: September 2023

O objetivo deste artigo é refletir sobre a importância da translinguagem na educação bilíngue de surdos, apontando exemplos de práticas que vêm sendo utilizadas no ensino de estudantes surdos. Para isso, foi realizada pesquisa bibliográfica em textos que discutem a importância da translinguagem em contextos educacionais bilíngues com foco na educação de surdos. A pesquisa bibliográfica evidenciou o valor inovador da translinguagem ao conceituar a linguagem como prática social, na qual professores e estudantes usam língua de sinais, língua majoritária, bem como outros recursos semióticos visando à aprendizagem bilíngue. Os exemplos apresentados neste artigo, encontrados tanto na literatura quanto na prática de uma das autoras, ilustram estratégias translíngues usadas por professores no ensino de estudantes surdos.
Similar, but Different: Gender Differences in Working Time Arrangements and the Work–Life Interface
Authors: Mazei Jens , Backhaus Nils , Wöhrmann Anne Marit , Brauner-Sommer Corinna , Hüffmeier Joachim
Published: September 2023

Gender inequities can be partly traced back to gender differences in working time arrangements. In fact, it is established knowledge that women as compared to men are more (less) likely to work part-time (overtime). Based on social role theory, however, we also expect gender differences among part-time and overtime workers, such that women and men differ in why they work part-time or overtime. In a preregistered and highly powered study conducted in Germany (N = 3,844–17,361, depending on the analysis), we observed that, on average, women were more likely than men to work part-time (i.e., fewer than 35 hours per week) because of personal or family obligations. Moreover, in comparison to men, women were less likely to work overtime (i.e., at least two hours per week) to attain additional income, but more likely to work overtime to step in for colleagues. Altogether, people had “gendered” reasons to work certain hours. Furthermore, as people’s paid working time arrangements are intertwined with their lives outside of the workplace, we examined women’s and men’s work–life interface and observed that women (as compared to men) deemed it less acceptable to be available for work-related issues during leisure time. We discuss implications for future theorizing and for practitioners who aim to design work schedules that consider the different lived experiences of women and men.
Sharpening the blades of the dentate gyrus: how adult‐born neurons differentially modulate diverse aspects of hippocampal learning and memory
Authors: Berdugo‐Vega Gabriel , Dhingra Shonali , Calegari Federico
Published: September 2023

For decades, the mammalian hippocampus has been the focus of cellular, anatomical, behavioral, and computational studies aimed at understanding the fundamental mechanisms underlying cognition. Long recognized as the brain's seat for learning and memory, a wealth of knowledge has been accumulated on how the hippocampus processes sensory input, builds complex associations between objects, events, and space, and stores this information in the form of memories to be retrieved later in life. However, despite major efforts, our understanding of hippocampal cognitive function remains fragmentary, and models trying to explain it are continually revisited. Here, we review the literature across all above‐mentioned domains and offer a new perspective by bringing attention to the most distinctive, and generally neglected, feature of the mammalian hippocampal formation, namely, the structural separability of the two blades of the dentate gyrus into “supra‐pyramidal” and “infra‐pyramidal”. Next, we discuss recent reports supporting differential effects of adult neurogenesis in the regulation of mature granule cell activity in these two blades. We propose a model for how differences in connectivity and adult neurogenesis in the two blades can potentially provide a substrate for subtly different cognitive functions.
Public Perception of Healthy Food in The Light of Interdisciplinary Scientific Certainty. Survey report
Authors:   Uniwersytet w Białymstoku, Farhan Jakub Ali , Kaczyński Piotr ,   Instytut Ochrony Roślin - Państwowy Instytut Badawczy, Perkowski Maciej ,   Uniwersytet w Białymstoku
Published: September 2023

In recent years, an alarming trend in the rising incidence of non-communicable diseases has led to increased interest in the issue of so-called "healthy food". Despite the enormity of food regulation, the concept of "healthy food" is not framed in any legal framework, and the public's understanding of it is uneven. So what is "healthy food" according to the public? This report contains the results of a survey aimed at answering this question. The survey consisted of two parts - on the one hand, a representative sample of 1,041 people was surveyed, and on the other hand, 100 food entrepreneurs were surveyed. The obtained results of the survey provide the research team with a starting point for further interdisciplinary research (legal sciences, chemical sciences, medical sciences) in the "healthy food" problem area.
Luminescent properties of the structures with embedded silicon nanoclusters: Influence of technology, doping and annealing (Review)
Authors:   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Melnik V.P. , Popov V.G. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Romanyuk B.M. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Antonin S.V. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Evtukh A.A. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine
Published: September 2023

Detection of photoluminescence (PL) in traditionally non-luminescent Si material (a typical indirect band semiconductor) attracts great attention both in the scientific aspect and for applications in the field of micro- and nanoelectronics and photoelectronics. Despite the success in technology and understanding of many features inherent to its PL characteristics, many problems have not yet been resolved. In particular – what is the origin of PL lines: quantum size, molecular complexes within SiO2, interface or volume localized states, etc. How to achieve the increase in the PL intensity and to provide excitation of it in different parts of the spectrum. The proposed review systematizes results of studies associated with these problems concerning the original technologies for creation of Si nanocrystals (nc-Si) and various research methods. In conclusion, we summarize the results on the properties of nc-Si-SiO2 luminescent structures depending on their technology of synthesis, photo- and structural features and application prospects for micro- and nanoelectronics as well as photoelectronics.
Influence of perovskite thickness on the performance of silver-doped NaZnBr3 perovskite solar cells using SCAPS software
Authors:   Department of Physics, Confluence University of Science and Technology, Osara, Kogi State, Nigeria, Abdulmalik M.O. ,   Department of Physics, University of Nairobi, Nairobi, Kenya, Danladi E. ,   Department of Physics, Federal University of Health Sciences, Otukpo, Benue State, Nigeria
Published: September 2023

The absorbing layer thickness is a crucial parameter that significantly impacts the performance of perovskite solar cells (PSCs). In this study, we investigated the influence of the thickness of absorbing layer on the performance of silver-doped NaZnBr3 perovskite solar cells using the one-dimensional solar cell capacitance simulator (SCAPS-1D) software. The absorbing layer thickness was varied in the range of 0.1 to 1.3 µm. The initial solar cell after simulation gave an open-circuit voltage (Voc) of 1.174 V, short circuit current density (Jsc) of 14.012 mA/cm2, fill factor (FF) of 79.649%, and the power conversion efficiency (PCE) of 13.101%. For the optimized thickness of the perovskite layer of 1.0 µm, the following solar cell characteristics were obtained: Voc = 1.197 V, Jsc = 18.184 mA·cm–2, FF = 79.110%, and PCE = 17.215%. A 31% and 30% increase of the PCE and Jsc, respectively, was observed for the optimized device parameters as compared to the initial ones. Such finding confirms the premise for excellent photon management and enhancement of PSCs performance by selecting the thickness of absorbing layer.
SPR chromatic sensor with colorimetric registration for detection of gas molecules
Authors:   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Riabchenko O.V. , Kukla O.L. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Fedchenko O.N. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Shirshov Yu.M. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine, Kazantseva Z.I. ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine 41, prosp. Nauky, 03680 Kyiv, Ukraine
Published: September 2023

In this work, we have proposed and tested a new version of an optoelectronic sensor for detecting gas molecules based on the effect of spectral surface plasmon resonance (SPR) in the chromatic mode with colorimetric registration of the R, G, B color components of reflected light. A thin 40-nm silver film on the base face of the prism with SPR excitation in the Kretschmann geometry is used as an optical sensitive element that allows us to realize a full-fledged SPR effect in the entire visible range of the spectrum from 450 to 700 nm. The physical nature of the sensory effect is a change in the refractive index of the sensitive coating on the silver film, which directly affects the SPR parameters. The films of polyvinyl formal ethylal were used as a coating selective to the number of organic analytes. A laboratory version of the portable device for implementation of a gas sensor based on the SPR-RGB effect was created. Performance of the proposed sensory method and the corresponding device were assessed using different types of alcohols as volatile organic analytes.
Infant Exercise Programs
Authors:   Committee on Sports Medicine
Published: September 2023

This Policy Statement was retired May 2004.

Infant exercise programs are becoming abundant in the United States. In most programs, massage techniques, passive exercises, and holding an infant in various positions are used. Some programs involve the purchase of "exercise equipment." Promoters have claimed that participation by an infant in these programs will improve physical prowess. In early infancy, the predominant neuromuscular responses are reflex in nature.1 Most activity at this age can be attributed to an intrinsic arousal-seeking drive. Natural curiosity and the drive toward self-sufficiency motivate infants in virtually all activities.2

Providing a stimulating environment for an infant's development is extremely important. Environmental deprivation will impede the developmental progress of an infant. There is some evidence that conditioned responses can be elicited in the newborn period. However, there have been no data to suggest that structured programs or the promotion of conditioned responses will advance skills or provide any long-term benefit to normal infants.3

The bones of infants are more susceptible to trauma than those of older children and adults. The skeletal system of the child in the first year of life is less than optimally ossified.4 Infants do not have the strength or reflexes necessary to protect themselves from external forces. The possibility exists that adults may inadvertently exceed the infant's physical limitations by using structured exercise programs.

Parents do not need specialized skills or equipment to provide an environment for the optimum development of their infant. An infant should be provided with opportunities for touching, holding, face-to-face contact, and minimally structured playing with safe toys.
Precautions Concerning the Use of Theophylline
Authors:   Committee on Drugs
Published: September 2023

This Policy Statement was retired January 2005.

Theophylline is commonly prescribed for pediatric patients with asthma, other forms of reactive airway disease, and apnea of prematurity.1-3 This statement is to remind physicians of the necessity to reduce the dosage of theophylline and to monitor the patient's serum concentration to prevent increased risk of toxicity when the drug is administered in the presence of acute febrile illness or in combination with certain medications.

The serum concentration of theophylline must be maintained within a relatively narrow range to achieve optimal therapeutic benefit while avoiding toxic side effects. While patients with milder airway disease may benefit from serum concentrations less than 10 mg/L, the greatest likelihood of obtaining maximal bronchodilatation with reasonable safety is achieved with peak serum concentrations between 10 mg/L to 20 mg/L.4-7 Serum concentrations of 6 mg/L to 12 mg/L are recommended when treating patients for apnea.3 Doses required to maintain theophylline concentrations within these ranges vary greatly due to large individual differences in theophylline metabolism.8-14

Undesirable side effects, including headaches, dizziness, nervousness, insomnia, anorexia, nausea, vomiting, and epigastric pain have been associated with serum theophylline concentrations which exceed the recommended therapeutic range.15-19

Concentrations greater than 30 mg/L carry an increased risk of more serious side effects, including hypokalemia, cardiac dysrhythmia, and seizures.18-22 Although seizures are uncommon at concentrations less than 40 mg/L,15,17 there is not a strong correlation between serum concentration and risk of seizures. Seizures have occurred in patients with serum concentrations less than 20 mg/L;17 in contrast, individuals have tolerated serum levels greater than 120 mg/L with no seizure activity.19
Effect of particle size on sensory and bioactive properties of chocolates with Physalis peruviana L and Vaccinium spp
Authors: Ordoñez Gomez Elizabeth Susana , Calderon Pino Joseferik , Reátegui Diaz Darlym
Published: September 2023

Chocolates are considered functional foods and are consumed worldwide. The objective was to evaluate the effect of particle size and the inclusion of Physalis peruviana L (Goldenberry) and Vaccinium spp (Andean blueberry) on sensory attributes, color, total phenols, and anthocyanins in dark and milk chocolate. The attributes of gloss, surface, breakage, melting, grittiness, odor, fruit scents, aftertaste, sweetness, mouthfeel, bitterness, and astringency were evaluated for sensory evaluation. To measure color, the CIELAB system was used. Phenols were evaluated using spectrophotometry and anthocyanins using the pH differential method. According to principal components analysis (PCA), dark chocolates with the inclusion of goldenberries had the best sensory scores (Øp =10-20 µm); the results for the correlations were 0.97 for surface and melting, 0.98 for surface and aftertaste, 1.0 for aftertaste and astringency, and -0.92 melting and odor. Milk chocolate with the inclusion of goldenberries (Øp =10- 20 µm) was superior in attributes such as fruit scents, sweetness, grittiness, gloss, odor, aftertaste, and mouthfeel. At the same time, there was a correlation between melting and aftertaste of -0.92 and between melting and mouthfeel of -0.94, odor with fruit scents and sweetness were 0.96 and 0.98, and fruit scents with aftertaste and sweetness were 0.94 and 0.99. Dark and milk chocolates with the inclusion of goldenberries (Øp =10-15 µm) were slightly superior in the phenol content, while chocolates with the inclusion of Andean blueberries (Øp =10-20 µm) had greater anthocyanin contents.
Bioactive compounds against Moniliophthora roreri (Cif & Par) identified in locally produced liquid amendments (Biols)
Authors: Manzano Santana Patricia Isabel , Magdama Tobar Freddy Arturo , Orellana Manzano Andrea , Ruiz Barzola Omar , Miranda Martínez Migdalia , Orellana León Tulio Fredi , Peralta García Esther Lilia
Published: September 2023

The use of liquid organic amendments (biols) is a common practice for farmers due to the multiple benefits in the management and production of their crops, including the control of pests and diseases. The present study analyzes the chemical composition of the pure compound C1 and fractions F2 and F3 of local biols produced in two provinces of Ecuador and their antifungal activity against Moniliophthora roreri (Cif & Par). This work incorporates the use of Gas Chromatography coupled to Mass Spectrometry (GC-MS), Nuclear Magnetic Resonance (NMR) and in vitro inhibition assays for sample analysis. C1 was identified as Mannitol. The percentage of inhibition against M. roreri in F2 and F3 was 44.37% and 8.34%, respectively; and, for C1, 28.63%. The values of the median lethal dose (LD50) obtained corroborate that the F2 fraction was the one with the highest controlling activity against the pathogen. The 1,2-benzenedicarboxylic acid diisooctyl ester compound was the main compound in F2 (30.88%) and the Pentadecanoic acid, 14-methyl-, methyl ester in F3. Finally, all compounds obtained from the biol fractions were identified and it was determined that the fermentative process was suitable for producing bioactive compounds of interest to inhibit the growth of Moniliophthora roreri.
Variance Gamma (nonlocal) equations
Authors: Colantoni Fausto
Published: September 2023

Some equations are provided for the Variance Gamma process using the definition other than that based on a time-changed Brownian motion. A new nonlocal equation is obtained involving generalized Weyl derivatives, which is true even in the drifted case. The connection to special functions is in focus, and a space equation for the process is studied. In conclusion, the convergence in distribution of a compound Poisson process to the Variance Gamma process is observed.
Predicting and understanding corrosion in molten chloride salts
Authors: Rippy Kerry , Witteman Liam , Taylor Patrick R. , Vidal Judith C.
Published: September 2023

Molten chloride salts are stable at higher temperatures than many other salts, including nitrate salts, and are thus promising for heat transfer and/or thermal energy storage in concentrating solar power, nuclear power, and other thermal energy storage applications. However, corrosion in molten chloride salts remains a significant problem. While many studies have been devoted to evaluation of corrosion, we find that a comprehensive method for predicting corrosion in molten chloride salts is lacking. Here, we present an evaluation of corrosion in molten chloride salts using Ellingham diagrams and chloride-oxide stability diagrams, which enable prediction of alloy performance in molten chloride salts and allow corrosion results to be interpreted at a fundamental level.

Graphical abstract
As informações sobre os direitos sociais estão acessíveis aos pacientes oncológicos?
Authors: Batista Fernanda Guedim , Szklo André Salem
Published: September 2023

A legislação brasileira assegura aos pacientes com câncer direitos que auxiliam no tratamento e atenuam os gastos despendidos na jornada de adoecimento. O objetivo do estudo foi calcular a proporção de indivíduos em tratamento oncológico de um centro de referência do Sistema Único de Saúde (SUS) que referiram conhecer 15 direitos específicos previstos em lei, segundo o subgrupo populacional elegível para solicitar cada direito. Foram entrevistados todos os pacientes oncológicos adultos em início de tratamento no Hospital Associação Feminina de Prevenção e Combate ao Câncer de Juiz de Fora (ASCOMCER), Minas Gerais, entre março e julho de 2022 (n = 62). Cerca de 60% desses pacientes eram analfabetos ou não tinham completado o ensino fundamental, aproximadamente 75% viviam em domicílios em que a renda per capita era de no máximo um salário mínimo e 91,9% eram atendidos pelo SUS. Para nove dos 15 direitos selecionados, a proporção de pacientes elegíveis foi superior a 10%, variando de 17,7% para “saque do Fundo de Garantia por Tempo de Serviço (FGTS)” a 100% para “prioridade na tramitação de processos”. No entanto, o único desses direitos conhecido por pelo menos 50% dos pacientes elegíveis foi o “auxílio-doença” (70,6%), sendo que para três direitos as respectivas proporções não chegaram a 5% (isenção de imposto sobre propriedade predial e territorial urbana, isenção do imposto de renda na aposentadoria, pensão e reforma e prioridade na tramitação de processos). Os pacientes oncológicos necessitam ter seus cuidados integrais fortalecidos. Dessa forma, é fundamental aumentar o acesso à informação sobre os benefícios que eles podem obter de um Estado democrático de direito.
Tuberculose no sistema prisional brasileiro: cenários via Joinpoint entre 2007 e 2019
Authors: Nóvoa-Lôbo Nancy Meriane de , Campos Mônica Rodrigues , Pires Débora Castanheira
Published: September 2023

Resumo: Este estudo descreveu e comparou dados de tuberculose (TB) entre pessoas privadas de liberdade e população geral brasileira, de 2007 a 2019, utilizando a ferramenta Joinpoint para observação de mudanças de tendências. Apresenta um recorte para mulheres e idosos, para testagem para HIV e para número de custodiados por vaga. Trata-se de um estudo retrospectivo, quantitativo e analítico, que utiliza métodos de regressão de dados de séries temporais a partir de dados secundários de acesso irrestrito coletados do Sistema de Informação de Agravos de Notificação (SINAN), do Instituto Brasileiro de Geografia e Estatística (IBGE) e de relatórios analíticos disponibilizados pelo Departamento Penitenciário Nacional (DEPEN). Os resultados retratam aumento da prevalência de TB consideravelmente maior em pessoas privadas de liberdade em todas as perspectivas analisadas; aumento nas testagens para HIV; e discutível tendência de estabilidade na quantidade de custodiados por vaga. Ao se analisar tendências de prevalências, serviços e determinantes, é curioso ver a não coincidência temporal na maioria dos casos. Ficou claro que as políticas nacionais de combate à TB não têm o mesmo efeito dentro das prisões e mesmo a Política Nacional de Atenção Integral à Saúde das Pessoas Privadas de Liberdade no Sistema Prisional (PNAISP) mostrou efeitos restritos diante da situação de saúde aqui analisada. Apesar de trabalhar com dados secundários de confiabilidade variável, alcançaram-se comparações que podem impactar decisões e ações de saúde. Ainda que carente de respostas completas e definitivas, pôde-se lançar um novo olhar à evolução de questões sobre as quais a reflexão é imprescindível.
Inquérito Telefônico de Fatores de Risco para Doenças Crônicas Não Transmissíveis em Tempos de Pandemia (Covitel): aspectos metodológicos
Authors: Hallal Pedro Curi , Rocha Angel Caroline Chirivino Antunes da , Sardinha Luciana Monteiro Vasconcelos , Barros Aluísio J. D. , Wehrmeister Fernando C.
Published: September 2023

Resumo: Este artigo descreve a metodologia utilizada na realização do Inquérito Telefônico de Fatores de Risco para Doenças Crônicas Não Transmissíveis em Tempos de Pandemia (Covitel), desenvolvido no Brasil em 2022. O Covitel é um inquérito de base populacional, com representatividade para o Brasil e suas cinco macrorregiões: Centro-oeste, Nordeste, Norte, Sudeste e Sul. O inquérito apresenta informações sobre o impacto dos principais fatores de risco para as doenças crônicas não transmissíveis (DCNT) na população adulta, com 18 anos ou mais, residente em domicílios servidos por linhas telefônicas fixas e móveis. O estudo tem por objetivo colaborar para o desenvolvimento e acompanhamento de políticas públicas voltadas para a promoção da saúde para a população, bem como obter resultados que visem contribuir para o conhecimento sobre a influência da COVID-19 nos fatores de risco para as DCNT no país. Foram avaliados 9 mil indivíduos e coletadas informações sobre alimentação, atividade física, saúde mental, estado de saúde, hipertensão arterial, diabetes e depressão, além do consumo de álcool e tabaco, comparando os momentos pré-pandemia e o primeiro trimestre de 2022. Além disso, o estudo coletou informações acerca do esquema vacinal da população e da infecção por COVID-19.
O processo de especialização e desespecialização em educação do Ministério Público de Goiás: uma análise da mudança
Authors: Rodrigues Rayane Vieira , Marinho Carolina Martins
Published: September 2023

Resumo: A partir de leituras neoinstitucionais e organizacionais, o texto propõe um modelo de análise sobre o processo de mudança no Ministério Público, destacando que os valores dos sujeitos que integram a organização devem ser reconhecidos no processo de formação da agenda. O modelo de estudo foi aplicado ao Ministério Público de Goiás (MPGO) e se propôs a compreender como se deu esse processo de mudança organizacional, retirando o tema da educação da agenda, apesar da sua importância. Constatamos que fatores exógenos podem induzir a especialização, mas as mudanças institucionais só permanecem se forem incorporadas pelos membros da organização. Fatores endógenos contribuem para, a partir de um rearranjo de forças, levarem a mudança de preferências e da estrutura organizacional.
Micropropagation of basil ‘Grecco a Palla’ mediated by 6-benzylaminopurine and 3-indole butyric acid
Authors: Gorski Felipe , Gerotti Geysiane Moreira , Magalhães Hélida Mara
Published: September 2023

ABSTRACT: The present study evaluated the efficiency of a protocol for micropropagation of stem apexes and nodal segments of basil ‘Grecco a Palla’ in various concentrations of 6-benzylaminopurine (BAP) and 3-indole butyric acid (IBA). A completely randomized design was used with six treatments distributed in five replications. A medium without growth regulators favored the survival of Ocimumbasilicum stem apexes inoculated in vitro, and thereby promoted the sprouting of explants, whereas, for nodal segments, it was necessary to use regulators, and the concentration of 0.5 mg.L−1 BAP 0.0 mg.L−1 of IBA was more beneficial for the species.
Co-feeding period on the survival and growth of larvae (Botia lohachata) during the feeding transition
Authors: Fosse Paulo José , Mattos Douglas da Cruz , Fosse Filho João Carlos , Cardoso Leonardo Demier , Radael Marcella Costa , Silva Maria Aparecida da , Vidal Junior Manuel Vazquez
Published: September 2023

ABSTRACT: This study evaluated the effect of the co-feeding (C) period on the growth and survival of larvae of the yo-yo loach Botia lohachata ornamental species during the weaning period from live food (LF) to inert food (IF). The breeders were subjected to induced spawning using crude pituitary homogenate. A total of 2,400 larvae were used with an average initial weight of 0.39 ± 0.09 mg and an average total length of 4.08 ± 0.21 mm, from a single breeding pair. The live food was newly hatched nauplii of Artemia franciscana, and the inert diet was a commercial ration with 55% crude protein and two particle sizes (142-350 µm and 350-500 µm). As the first food, all larvae received A. franciscana during the first six days, except for the fasting (NC) and inert food (IF) groups. The following co-feeding strategies were employed: C4 = 4 days of co-feeding, C8 = 8 days of co-feeding, C12 = 12 days of co-feeding, and LF = Artemia during the entire experimental period. The longest period with live food promoted better larval growth rates. The specific growth rate of larvae fed live food during the entire period (LF) was higher than that of the other groups, followed by the co-feeding strategies. There was no effect (P > 0.01) on larval survival in the LF, C12, C8, and C4 groups, which ranged from 41% to 53% after 30 days. Treatment R resulted in high mortality and low growth, suggesting that live food should be the first food source for B. lohachata larvae.
Application of lyophilized purple-fleshed sweet potato powder as a multifunctional ingredient in Greek yogurt
Authors: Cunha Júnior Paulo Cezar da , Silva Mariá Toledo de Carvalho , Barbosa Maria Ivone Martins Jacintho , Ferreira Elisa Helena da Rocha
Published: September 2023

ABSTRACT: Purple-fleshed sweet potato is a tuber rich in anthocyanins, which are phenolic pigments that confer color and present bioactive capacity. Moreover, its incorporation into dairy products can bring technological and functional benefits. Thus, this article evaluated the impact of the addition of lyophilized purple-fleshed sweet potato powder- LP (0% - Control, 2%, and 4%) on the physical, chemical, and technological characteristics of Greek yogurt. LP showed in vitro antioxidant and bioactive capacity by DPPH (20.64 ± 1.61 μmol TE g-1), FRAP (112.93 ± 4.38 μmol TE g-1), total phenolic content (103.66 ± 3.35 mg GAE g-1), and total anthocyanin content (51.10 ± 1.87 mg cyanidin 3-glucoside 100 g-1). Additionally, the assays demonstrated that the LP has 16.82 ± 0.63% of resistant starch. The fortification of Greek yogurt with LP reduced the syneresis, indicating that LP increased the water retention capacity. LP also inhibited the post-acidification process, increasing apparent viscosity, hardness, and gumminess, and promoting a stable pink coloration throughout the storage (P < 0.05). At the 4% level, the yogurt was firmer and showed greater chewiness, which is highly desirable for Greek yogurt. Therefore, the results suggested that lyophilized purple-fleshed sweet potato powder is a potential multifunctional natural ingredient.
Chrysin flavonoid encapsulation: a review about methodologies used and biological potential
Authors: Filho Carlos Borges , Gomes Marcelo Gomes de , Kemmerich Magali , Deus Cassandra de , Menezes Cristiano Ragagnin de
Published: September 2023

ABSTRACT: Chrysin flavonoid has been presented as having numerous and promising bioactive effects, such as antioxidant, anticonvulsant, antihypertensive, anti-inflammatory, antineoplastic, antihyperlipidemic, and antidepressant. However, one of the main challenges for advances in studies on the bioactivity of chrysin is its low bioavailability in humans. Thus, aiming to overcome this barrier, several studies have demonstrated the bioactive potential of capsules containing chrysin. The objective of this review was to present the main methodologies used for the encapsulation of chrysin, and its main biological effects demonstrated so far. Our intention is to offer ways to advancement of research in the area of flavonoid encapsulation. As for the encapsulation techniques, it was found that they are diverse, and the most recurrent encapsulating agents were PEG, PLGA polymers and their derivatives, in addition to other agents, such as PCL, albumin, lipids and chitosan.The bioactive effects of the capsules are also numerous, and anticarcinogenic effects are the most frequent, in addition to other effects such as antioxidant, antidiabetic, antimicrobial and neuroprotective. In conclusion, we verified a lack of use of green techniques for the encapsulation of chrysin, and the production of lipid-water emulsions and the dissolution of chrysin in ethanol seems to be alternatives in this regard. In addition, bioactive potential of these capsules can be evaluated in other experimental models, and should advance to clinical trials and application in food formulations.
Social customer relationship management and organizational resilience of Brazilian microenterprises during the Covid-19 pandemic
Authors: Andrade Guilherme A. S. , Espejo Márcia M. S. B. , García-Contreras Rigoberto , Santos Cleston Alexandre dos
Published: September 2023

Abstract Purpose: To measure the impact of using social media as a management tool (social customer relationship management) on the organizational resilience of Brazilian microenterprises during the Covid-19 pandemic crisis. Originality/value: Organizational resilience has been a widely investigated topic during the Covid-19 pandemic crisis. In this context, the relationship with the customer via social media was paramount. However, the elements that explain the different results obtained with social media use are still unclear, especially in Brazil, a gap that the present study seeks to decrease. Design/methodology/approach: Quantitative research was carried out and operationalized by questionnaires made available through digital channels. The return of 100 respondents (non-probabilistic sample) was obtained. Data were analyzed using descriptive statistics tools, non-parametric means test, and structural equation modeling by partial least squares method. Findings: The results corroborate the importance of developing organizational resilience in microenterprises in times of crisis. According to the hypothesis test, the model suggests that the mere use of social media is not enough to trigger positive developments in organizational resilience. However, when mediated by management tools, the relationship becomes significant. Therefore, an explanation is offered for the different results obtained by microenterprises using social media for strategic purposes.
Políticas para agricultura na Amazônia: análise dos convênios celebrados entre a União e os entes subnacionais
Authors: Lui Lizandro , Catini Bruno , Miquelino Wanessa
Published: September 2023

Resumo O artigo analisa as transferências voluntárias de recursos do Ministério da Agricultura, Pecuária e Abastecimento (MAPA) para entidades situadas na região da Amazônia Legal, entre 2008 e 2022. Os dados utilizados foram obtidos da plataforma Transferegov do Governo Federal e foram aplicadas técnicas de análise de conteúdo. O estudo considerou teorias sobre transferências voluntárias de recursos, instrumentos de políticas públicas e mudanças governamentais. Os resultados revelam que, durante o período analisado, o Congresso Nacional se tornou o principal financiador dos convênios direcionados à Amazônia Legal, enquanto o Poder Executivo reduziu sua participação. Além disso, observou-se mudanças significativas nos objetivos dos investimentos. Por um lado, houve uma diminuição nos recursos destinados à capacitação de agricultores, políticas para mulheres e quilombolas e, por outro, houve um aumento no direcionamento de investimentos em maquinários agrícolas. A pesquisa conclui que o arranjo institucional brasileiro permite que convênios sejam utilizados como forma de alocar recursos de acordo com interesses políticos. O estudo defende um papel mais ativo do Poder Executivo Federal como coordenador do processo de distribuição de recursos.
Avaliação de variedades frutíferas: o caso do maracujá-azedo cultivado em São Paulo, Brasil
Authors: Bezerra Luiza Maria Capanema , Fredo Carlos Eduardo , Purquerio Luis Felipe Villani
Published: September 2023

Resumo Esta pesquisa teve como objetivo a proposição de um protocolo metodológico para avaliação de impactos de cultivares frutíferas adotadas pelo setor agropecuário e a validação com cultivares de maracujá-azedo (Passiflora edulis Sims). O protocolo foi baseado no estudo do contexto da pesquisa, desenvolvimento e inovação (PD&I) em que o objeto avaliado estava inserido, identificação de indicadores e definição de critérios para a mensuração de adicionalidade e causalidade. Os resultados contribuíram para a estruturação de um protocolo metodológico de avaliação de impactos fundamentado por indicadores para caracterização socioeconômica de Unidade de Produção Agropecuária (UPA) e para a mensuração de impacto direto com o uso cultivares frutíferas. No caso de estudos de avaliação de impacto cultivares frutíferas, salienta-se a importância do conhecimento dos processos de P&D, difusão e adoção, como também características socioeconômicas das UPAs. A validação do protocolo em um conjunto de produtores de maracujá-azedo, permitiu identificar que tanto os indicadores de caracterização socioeconômica como os de impacto são passíveis de serem utilizados para avaliar o impacto de diferentes cultivares de frutíferas.
Assessing sustainability performance: a comprehensive overview of the Portuguese wine sector
Authors: Trigo Ana , Fragoso Rui , Marta-Costa Ana
Published: September 2023

Abstract Sustainability assessment is a very subjective and complex procedure. However, whether to cope with climate change, market pressures or new environmental policies, winegrowers are today looking for ways to improve and measure their performance. Nevertheless, there is still a great demand of more information and better evaluation methodologies as most of general assessment frameworks are environmentally focused, non-context-comprehensive or even unfit to evaluate permanent crops such as viticulture. To consider context-comprehensiveness is therefore seen as fundamental in research of this nature. Our objective is to explore nationwide perceptions of upper echelon individuals from the Portuguese wine industry regarding sustainability issues and better ways to assess it. By covering nine of the 14 wine regions in Portugal, the aim is to spot intercultural trends and get a wider picture of the sector´s sustainability awareness. A grounded theory approach was used for the complexity of the topic and for allowing to uncover potential perspective-paradoxes or trade-offs. After collecting data through in-depth interviews, an inductive qualitative-content analysis was applied using IRAMUTEQ software. Results displayed key criteria and insights grouped in four clusters from three distinct ramifications. Beyond the mention of critical factors about the sector´s environmental impacts from the production to packaging phase, distribution and transportation, concerns regarding intergenerational equity gap and non-equitable development opportunities for rural areas were also gathered. One ramification was based on the need to have access to proper sustainability assessment tools. From the urgency to develop a sustainability framework or even certification scheme for increasing consumer demands and export market pressures, to the importance to provide a practical toolkit with lifecycle guidelines, user-friendly and able to support decision-making, two clusters were created. This study reported findings can serve as a reference to wine managers and policy-makers pursuing sustainable development goals.
Forensic Nursing competencies in disasters situations: scoping review
Authors: Silva Thiago Augusto Soares Monteiro da , Haberland Débora Fernanda , Kneodler Thais da Silva , Duarte Alex Coelho da Silva , Williams Joyce , Oliveira Alexandre Barbosa de
Published: September 2023

ABSTRACT Objective: To map sources of technical-scientific information on Forensic Nursing competencies in disasters situations. Method: Scoping review developed in accordance with the JBI methodology, carried out in three stages by two reviewers independently on selected databases and gray literature, using keywords and descriptors. After reading them in full, we proceeded with data extraction and content analysis of 28 publications. Results: Identified 24 publications in English, 20 of which were produced in the United States of America. 24 competencies of forensic nurses in disasters situations were mapped, including: training; resource management; link with the justice service; direct care; psycho-emotional care; collection and preservation of traces; registration and documentation with photography; body management; maintenance of the chain of custody; and epidemiological surveillance. Conclusion: The forensic nurse acts in all phases of disasters with the affected people, families and communities, under an interdisciplinary perspective. The development of competencies aimed at the practice of Forensic Nursing in disasters should be incorporated into the training strategies of these professionals, in order to obtain better response standards.