bluuebunny/crossref_metadata_2025 huggingface dataset:
A randomised feasibility study of serial magnetic resonance imaging to reduce treatment times in Charcot neuroarthropathy in people with diabetes (CADOM)
Authors: Gooday Catherine , Game Frances , Woodburn Jim , Poland Fiona , Sima Erika , Dhatariya Ketan , Shepstone Lee , Barton Garry , Hardeman Wendy
Published: August 2022

Aim This study aims to explore the feasibility of using serial MRI without contrast in the monitoring of Charcot neuroarthropathy to reduce duration of immobilisation of the foot, in order to decide whether a large-scale trial is warrantedMethodsA multicentre, randomised, prospective, two arm, open, feasibility study (CADOM) of people with diabetes with a suspected or confirmed diagnosis of Charcot neuroarthropathy . Participants were randomised (1:1) to ‘standard care plus’, including repeated foot temperature measurements and X-rays, or the intervention arm, with additional three-monthly MRI, until remission of Charcot neuroarthropathy or a maximum 12 months (active phase). Participants were then followed-up for a further six months, post remission to monitor for relapse of the Charcot neuroarthropathy (follow-up phase). Feasibility outcomes were recruitment, retention, data completeness and safety of the intervention MRI. We also collected clinical, and patient reported outcomes, and data on health and social care usage to inform a future cost effectiveness analysis.ResultsOne-hundred and five people were assessed for eligibility at five sites. 64/105 potential participants meet the eligibility criteria to participate in the study Forty-three participants were randomised: 20 to standard care plus and 23 to MRI intervention. The main reason for ineligibility was a previous episode of Charcot neuroarthropathy . Thirteen participants were withdrawn post-randomisation due to an alternative diagnosis being made diagnosis. Of the remaining 30 participants, 19 achieved remission, 6 had not gone into remission at the end of the 12-month active phase so exited the study. Five participants were lost to follow-up. Of the MRIs that were not disrupted by COVID-19 pandemic 26/31 (84%) were completed. As this was a feasibility study it was not designed to test the effectiveness of serial MRI in diagnosing remission. However, there was no statistical difference in the time in off-loading device between the two arms of the study: Hazard Ratio (HR) 0.405 (95% CI 0.140-1.172), p=0.096 .DiscussionThe findings support a definitive randomised controlled trial to evaluate the effectiveness of MRI in diagnosing remission in Charcot neuroarthropathy. The rates of recruitment, retention, data, and MRI completeness show that a definitive study is feasible.Study registration ISRCTN, 74101606. Registered on 6 November 2017.http://www.isrctn.com/ISRCTN74101606?q=CADom&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10&searchType=basic-search
Hessian-based weighted guided image filtering
Authors: Wu Jiaxin , Xie Shoulie , Cao Wei , Wu Shiqian
Published: August 2022

Guided image filtering (GIF) is a popular edge-preserving smoothing technique, and the regularization parameter selection plays an important role in the performance of GIF. In this paper, we propose a new guided image filter based on Hessian matrix which consists of the second-order derivatives of an image. More specifically, a new structural measurement index is introduced by using the eigenvalues of the Hessian matrix first, which can distinguish the texture and flat regions of the image. Then the regularization parameter is adjusted based on this Hessian-based second-order structure measurement index, that is, a large regularization parameter is selected to improve the smoothness of the flat regions, while a small regularization parameter is set for the texture regions to preserve the image structure such as edges and corners. To further improve the quality of the filtered images, we also introduce a weighted averaging technique to the linear filter coefficients based on local variance. Experimental results show that the proposed Hessian-based weighted guided image filtering (HWGIF) method outperforms the state-of-the-art approaches in image processing applications such as edge-preserving denoising, detail enhancement, dehazing and HDR compression.
“Shelter My Soul with Your Body” – A Burial Custom Influenced by Shamanism: A Case of Covering a Dead Face with the Right Ribs of a Local Sheep in Inner Mongolia, China
Authors: Ban Lin , Lv Xiaohong , Cai Dawei , Liu Yiwen , Che Haoyu , Wang Chunxue , Cao Jianen , Zhang Zhe
Published: August 2022

Death represents the termination of all biological functions that sustain an organism and is inevitable in the ordinary life of people. Throughout history, death has been a topic of discussion. The emotion of fear of death has existed since the birth of human beings and has become even more so after civilization. To alleviate the fear of death, the unknown thing, primitive people began to explain death with their own world outlook; thus, the primitive concept of soul and religion came into being. Death is accompanied by the soul, and the fear of death gradually evolved into the awe of the soul, which gradually turned to practical action under the catalysis of primitive religion. Humans began to express their feelings (veneration or contempt) for the deceased in various practical behaviours and rituals that evolved into many fixed forms of burial or sacrificial customs after death. Shamanism is one of them. It is popular among nomadic groups in northern Eurasia, where many archaeological studies of shamanism have been conducted. This paper examined the phenomenon of covering a dead face with all the right ribs of a sheep at Nairentaoligai (乃仁陶力盖)Cemetery M17 in Inner Mongolia, China. These ribs were carefully researched by zooarchaeological methods, and we defined the basic information about the sheep. Then, we recovered the dismemberment process of the sheep by observing the traces on the bone surface and found that the dead face was covered by all the right ribs of a sheep in this tomb. This may have been to practice a particular idea. In connection with the shamanism culture prevalent in the area, we consider that this act may have been intended to declare the death of the body and shelter the soul of the dead from intrusion. This reflects shamanism culture on burial customs. This discovery is of great significance for the research of religious beliefs and death views of the northern nomadic people of the Mongolian Plateau region.
Demoralization profiles and their association with depression and quality of life in Chinese patients with cancer: A latent class analysis
Authors: Lin Fumei , Hong Yuting , Lin Xiujing , Chen Qingqin , Lin Yu-an , Chen Qiuhong , Huang Feifei
Published: August 2022

PurposeThe study aimed to identify latent classes of demoralization and examine their association with depression and with quality of life (QOL) among patients with cancer.MethodsCross-sectional data from 874 patients with cancer from three tertiary hospitals in Fujian province were collected using a convenience sampling method. Demoralization, depression, and QOL were assessed using the Chinese version of the Demoralization Scale-II, Patient Health Questionnaire-9, and McGill Quality of Life Questionnaire. Latent class analysis was performed on demoralization profiles. Binary logistic regression and multiple stepwise linear regression were used to examine the identified classes’ associations with depression and QOL.ResultsThree latent classes of demoralization were identified: the “low demoralization and emotional disturbance” class (Class 1; 49.6%); “moderate demoralization and meaninglessness” class (Class 2; 29.1%); and “high demoralization and existential despair” class (Class 3; 21.3%). The severity of depression increased and the levels of QOL decreased with the three classes of demoralization. Patients with cancer in Classes 1 and 2 were 0.128 and 0.018 times more likely to be depressed than those in Class 3, respectively, whereas the magnitudes of decrease in QOL scores for Classes 2 and 3 were 0.378 and 0.629, respectively. ConclusionThis study revealed three heterogeneous classes of demoralization in Chinese patients with cancer and indicated that increased classes were associated with more severe depression and decreased QOL. Targeted, step-by-step psychological interventions should be developed and implemented according to the characteristics of each class of demoralization to effectively promote psychological well-being among patients with cancer.
Disulfiram Alleviates Acute Lung Injury and Related Intestinal Mucosal Barrier Impairment by Targeting GSDMD-Dependent Pyroptosis
Authors: Zhao Jiping , Wang Hong , zhang Jintao , Ou Fuwei , Wang Junfei , Liu Tian , Wu Jinxiang
Published: August 2022

Background: Pyroptosis was implicated in acute lung injury (ALI). Disulﬁram is reported as an effective pyroptosis inhibitor by inhibiting gasdermin D(GSDMD). However, the function of pyroptosis executor GSDMD and treatment of disulﬁramon on ALI, especially whether it was involved in ALI-associated intestinal mucosal barrier impairment remains unclear. This study aims to explore the role of pyroptosis and disulﬁram’ treatment on ALI and related intestinal mucosal barrier impairment.Methods: First, we established lipopolysaccharide (LPS)-induced ALI models in wild-type and Gsdmd knockout (Gsdmd−/−), to detect the effect of pyroptosis on ALI-related intestinal mucosal barrier impairment. Furthermore, we used wild-type mice treated with disulﬁram to investigate the treatment of disulﬁram on ALI and related intestinal mucosal barrier impairment. Results: The data showed that GSDMD-mediated pyroptosis was activated in both lung and intestinal mucosa tissues in LPS-induced ALI, and deficiency of Gsdmd ameliorated LPS-induced ALI and related intestinal mucosal barrier damage. We also disclosed that disulﬁram inhibited the pyroptosis level, and alleviated ALI and related intestinal mucosal barrier impairment induced by LPS.Conclusions: These ﬁndings suggested the role of GSDMD-mediated pyroptosis and the potential application treatment of disulﬁram in ALI and related intestinal mucosal barrier damage.
Chemical shift assignments of a fusion protein comprising the C-terminal-deleted hepatitis B virus X protein BH3-like motif peptide and Bcl-xL
Authors: Kusunoki Hideki , Hamaguchi Isao , Kobayashi Naohiro , Nagata Takashi
Published: August 2022

Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of liver diseases including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). HBV has the multifunctional protein, HBV X protein (HBx, 154 residues), which plays key roles in HBV replication and liver disease development. Interaction of HBx through its BH3-like motif with the anti-apoptotic protein Bcl-xL leads to HBV replication and induction of apoptosis, resulting in HCC development. Our previous nuclear magnetic resonance (NMR) study revealed that the HBx BH3-like motif peptide (residues 101–136) binds to the common BH3-binding groove of Bcl-xL. Importantly, a C-terminal-truncated HBx, e.g., residues 1–120 of HBx, is strongly associated with the increased risk of HBV-related HCC development. However, the interaction mode between the C-terminal-truncated HBx and Bcl-xL remains unclear. To elucidate this interaction mode, the C-terminal-deleted HBx BH3-like motif peptide (residues 101–120) was used as a model peptide in this study. To facilitate the NMR analysis, we prepared a fusion protein of HBx(101–120) and Bcl-xL connected with five repeats of the glycine-serine dipeptide as a linker. Here, we report the 1H, 13C, and 15N resonance assignments of the fusion protein. This is the first step for the elucidation of the pathogenesis of liver diseases caused by the interaction between the C-terminal-truncated HBx and Bcl-xL.
Long-Term Outcomes of Revisional One anastomosis Gastric Bypass Post Laparoscopic Sleeve Gastrectomy
Authors: Sabah Salman Al , Haddad Eliana Al , Al-Subaie Saud , Ekrouf Shehab , Almulla Ahmad , Alhaddad Mohannad , Aljabal Mais Shiekh , Alenezi Khaled
Published: August 2022

Purpose
Revisional bariatric surgeries following laparoscopic sleeve gastrectomy’s (LSG) have demonstrated a dramatic increase worldwide. Recently, one-anastomosis gastric bypass (OAGB) has become a contender as an appropriate revisional procedure, however, no long-term data currently exist on the effectiveness of it as a revisional surgery post-LSG.
Methods
A retrospective analysis was performed on all patients who underwent LSG at a public hospital in Kuwait from 2008–2017. A list was obtained of those who underwent revisional OAGB surgery after initial LSG, after which a phone survey was performed and their demographics were analyzed.
Results
A total of 29 patients underwent revisional OAGB post-initial LSG, of which 89.7% were female. Prior to LSG, the mean weight of the patients was 127.5Kg and the mean BMI was 49.0Kg/m2. The mean weight loss after initial LSG was 43.8kg; while the average duration until patients underwent revisional SAGB was 5.3 years. The cause for revision was weight regain (86.2%), or inadequate weight loss (13.8%). Prior to undergoing revisional OAGB, the weight and BMI of the patients was 110.9kg and 42.4Kg/m2 respectively. This demonstrated a %excess weight loss of 14.5%, 31.9%, 48.0%, 56.3%, 57.2%, and 54.7% at 2 weeks, 3 months, 6 months, 1-year post, 4-years and 5-years post-OAGB, respectively. Twelve morbidities were reported during the follow-up period.
Conclusion
Revisional bariatric surgery is technically demanding and may be associated with a high complication rate. However, OAGB as a revisional procedure has proven to be safe and effective in the long-term outcomes of patients that undergo it post-LSG.
Does adding vaginal oestradiol after oral oestradiol facilitate artificial autologous freeze-thaw embryo transfer cycles? A retrospective cohort study
Authors: Li Ran , Wu Hai-Cui , Xiang Shan , Jia Zhi-Cheng , Lian Fang , Guo Ying
Published: August 2022

Research question: This study investigates the difference in reproductive outcomes with the late addition of vaginal oestradiol to oral oestradiol in artificially cycled frozen embryo transfer (AC-FET) cycles. Design: This retrospective cohort study was conducted at a university-affiliated tertiary care hospital. We divided 806 infertility patients who underwent programmed pre-FET endometrial preparation from January 2018 to July 2021 into two independent groups: Group A (591 with oral estradiol valerate only) and group B (215 with late oral estradiol valerate plus vaginal 17 β-estradiol). The primary outcome was the live birth rate (LBR), and the secondary outcome was other pregnancy-related outcomes. Propensity score matching (PSM) and multivariate logistic regression were applied to analyze all pregnancy outcomes, with a subgroup analysis based on vaginal oestradiol dose for group B. A subanalysis of cycles with endometrial thickness < 8 mm on the day prior to progesterone was also performed to assess the effect of adding vaginal oestradiol late in the thin endometrial transplantation cycle on reproductive outcomes.Results: Before and after PSM analysis, the live birth rates in group A were 41.1% and 42.2%, significantly higher than 31.2% and 30.8% in group B (P=0.015), respectively. Multiple logistic regression analysis demonstrates that group B was less likely to have a live birth than group A (OR 0.643, 95% Cl 0.453-0.913, P=0.014). Subgroup analysis of group B according to vaginal oestradiol dose demonstrated an insignificant difference in live birth rates between the subgroups (42.6% vs. 26.8% vs. 34.6%, P=0.118). In thin endometrial transplant cycles with an endometrial thickness < 8 mm on the day prior to progesterone, live birth rates were similar in both groups (36.9% vs. 26.8%, P=0.234).Conclusion: The addition of vaginal oestradiol as part of an artificial endometrial preparation (AEP) at a late stage of oral oestradiol significantly reduced LBR in autologous frozen-thawed embryo transfer, is independent of the dose of vaginal oestradiol, and does not improve the reproductive outcome in thin endometrial transfer cycles. However, more well-designed randomized clinical trials merit further investigation to confirm this conclusion.
Computing optimal drug dosing with OptiDose - Implementation in NONMEM
Authors: Bachmann Freya , Koch Gilbert , Bauer Robert , Szinnai Gabor , Pfister Marc , Steffens Britta
Published: August 2022

Finding a drug dosing recommendation with a PKPD model for an individual or a target population can be a laborious and complex task. Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal doses for any pharmacometrics / PKPD model for a given dosing scenario. In this work, we reformulate the underlying optimal control problem and elaborate how to solve it with standard commands in the software NONMEM. To demonstrate the potential of the OptiDose implementation in NONMEM, four relevant but substantially different optimal dosing tasks are solved. In addition, the impact of different dosing scenarios as well as the choice of the therapeutic goal on the computed optimal doses are discussed.
Identification of a novel intronic variant of ATP6V0A2 in a Han-Chinese family with Cutis Laxa
Authors: Shu Jianbo , Zhang Ying , Zhao Yiran , Zhang Fang , Liu Yang , Cai Chunquan
Published: August 2022

Background
Cutis laxa is a connective tissue disease caused by abnormal synthesis or secretion of skin elastic fibers, leading to skin flabby and sagging in various body parts. It can be divided into congenital cutis laxa and acquired cutis laxa, and inherited cutis laxa syndromes is more common in clinic.
Methods
In this study, we reported a case of a Han-Chinese male baby with ATP6V0A2 gene variant leading to cutis laxa. The proband was identified by whole-exome sequencing to determine the new variant, and their parents were verified by sanger sequencing. Bioinformatics analysis and minigene assay were used to verify the effect of this variant on splicing function.
Results
The main manifestations of the proband are skin laxity, abnormal facial features, and enlargement of the anterior fontanelle. Whole-exome sequencing showed that the baby carried a non-canonical splicing-site variant c.117 + 5G > T, p. (?) in ATP6V0A2 gene. Sanger sequencing showed that both parents of the proband carried the heterozygous variant. The results of bioinformatics analysis and minigene assay displayed that the variant site affected the splicing function of pre-mRNA of ATP6V0A2 gene.
Conclusions
In this study, it was identified that ATP6V0A2 gene c. 117 + 5G > T may be the cause of the disease. Few non-canonical splicing variants of ATP6V0A2 gene were reported in the past, and this variant expands the variants spectrum of the gene. The functional study of minigene assay plays a certain role in improving the evidence level of splicing variants, which lays a foundation for prenatal counseling and follow-up gene therapy.
Epidemiology of in-hospital burn patients in a tertiary hospital in Damascus, Syria.
Authors: Torbey André , Shibani Mosa , Alzabibi Mhd Amin , Eddin Ahmad Saad , Ammar Ali
Published: August 2022

Background
According to the WHO, 300,000 people die every year as a result of burn injuries. In this study, we aim to discuss the epidemiology and outcomes of burn patients who were admitted to Al Mowasat hospital in Damascus, Syria.
Methods
A retrospective cohort research was conducted from January 2017 to December 2021. All accessible paper-based medical records of burn injury patients admitted to the hospital were evaluated. ABSI score was used to classify injury degree. Chi-square test and logistic regression model were used to study the association between demographic variables and outcomes.
Results
Of the 641 patients, 367 (57.3%) were male and 274 (42.7%) were female. Children represented more than half of our sample 377 (58.8%). The most common cause of burn was flame burns 393 (61.3%), followed by scalding 199 (31.0%). Most of the patients had a more than 10% TBSA of burns 511(79.7%). Children had higher rates of leaving against medical advice (25.7%) than adults (17.8%). Children and patients who needed respiratory support were more likely to die than others 2.545 (1.079–6.004), 9.208 (4.061–20.879), respectively.
Conclusion
The situation of burn patients in Syria requires more attention and care to reduce mortality and morbidity. Focusing on the young age group to prevent such life-limiting injuries should be a priority.
Real-Life Disease Monitoring in Follicular Lymphoma Patients Using Liquid Biopsy Ultra-Deep Sequencing and PET/CT
Authors: Jiménez-Ubieto Ana , Poza Maria , Martin Alejandro , Ruiz-Heredia Yanira , Dorado Sara , Figaredo Gloria , Rosa-Rosa Juan Manuel , Rodriguez Antonia , Barcena Carmen , Parrilla-Navamuel Laura , Carrillo Jaime , Perez Ricardo Sanchez , Rufian Laura , Juarez Alexandra , Rodriguez Margarita , Wang Chonwu , de Toledo Paula , Grande Carlos , Mollejo Manuela , Casado Luis , CALBACHO Maria , Baumann Tycho , Rapado Inmaculada , Gallardo Miguel , Sarandeses Pilar , Ayala Rosa , Martínez-López Joaquín , Barrio Santiago
Published: August 2022

In the present study, we screened 84 Follicular Lymphoma patients for somatic mutations suitable as liquid biopsy MRD biomarkers using a targeted next-generation sequencing (NGS) panel. We found trackable mutations in 95% of the lymph node samples and 80% of the liquid biopsy baseline samples. Then, we use an ultra-deep sequencing approach with 2 · 10− 4 sensitivity (LiqBio-MRD) to track those mutations on 156 follow-up liquid biopsy samples from 55 treated patients. Positive LiqBio-MRD correlated with a higher risk of progression both at the interim evaluation (HR 13.0, 95% CI 2.70–63.4, p < 0.001) and at the end of treatment (EOT, HR 14.3, 95% CI 4.4–46.4, p < 0.001). Similar results were observed by PET/CT Deauville score, with a median PFS of 19 months vs. NR (p < 0.001) at the interim and 13 months vs. NR (p < 0.001) at EOT. LiqBio-MRD and PET/CT combined identified the patients that progressed in less than two years with 89% sensitivity and 100% specificity. Our results demonstrate that LiqBio-MRD is a robust and non-invasive approach, complementary to metabolic imaging, for identifying FL patients at high risk of failure during the treatment and should be considered in future response-adapted clinical trials.
Prevalence and Risk Factors of Binge-eating Disorder among Bahraini Youth and Young Adults: a cross-sectional study
Authors: Abdulla Zahraa A.rasool Abbas , Almahmood Hend Omar , Alghasra Razan Raed , Alherz Zahra Abdulameer Sadeq , Alsharifa Husain A.Ghaffar , Qamber Seham Jamal , Alomar Nadia Aaref , Almajed Fatema Ebrahim , Almahroos Taher Reyadh , Alnajjas Zainab Ali , Alsayyad Adel Salman
Published: August 2022

Background Binge-eating disorder (BED) is defined as recurrent abnormal ingestion of large amount of food in a discrete period of time. BED has the highest prevalence of all eating disorders (EDs). Studies have shown strong relationship between BED and both physical and psychological factors such as obesity, depression and anxiety. This research aimed to highlight the significance and predisposing factors of BED among Bahrainis (aged 15-30).Methods959 participants (aged 15–30 years) completed self-administered online questionnaires. BED was measured using the binge eating disorder screener-7 (BEDS-7). The questionnaire also included the Patient health questionnaire -9 (PHQ-9) And general anxiety disorder -7 (GAD -7) to measure depression and anxiety, respectively. Results Out of all participants, 21.2% had binge eating symptoms. Higher BMI, restrictive diet, depression and anxiety were associated with higher binge eating. Out of all risk factors, depression had the strongest association with a value of (p<0.0001, r=0.371) . However, sociodemographic variables including age and other medical conditions showed no statistical significance. Conclusion In conclusion, the prevalence of binge-eating disorder symptoms was significantly high among the study participants. The results point out the crucial role of awareness of the interaction between obesity, depression and anxiety as potential risk factors for binge eating tendencies. Further research should seek to examine their relationship with BED.
A Longitudinal Retrospective Study of a Wearable Neuromuscular Electrical Stimulation (NMES) System Shows Significant Improvement of Arm Usage in Hemiparetic and Hemiplegic Patients
Authors: Muccio Philip , Salama Rafik , Chopra Nipun , Scheuller Josh , Durrant David , Dabrowski Edward
Published: August 2022

Background
Hemiparesis and hemiplegia are commonly observed motor consequences of brain injury and infarction. Brain disorders such as traumatic brain injury (TBI), stroke (cerebrovascular accident, or CVA), and cerebral palsy (CP), as well as surgical interventions, can result in aberrant motor function in the contralateral upper and lower limbs, resulting in paralysis, weakness and/or spasticity in the arm and leg. NMES has been previously used to stimulate affected muscle groups and to increase arm mobility in a variety of brain and spinal cord diseases, yet there remains a paucity of longitudinal evidence examining NMES-mediated improvements in arm usage after brain compromise.
Methods
In this retrospective cohort study (n = 38), we examined longitudinal (up to 10 years) self-reported arm usage in patients with 1) TBI, 2) stroke, 3) prior hemispherectomy, or 4) cerebral palsy who wore an NMES device, Axiobionics’ BioSleeve, and we compared this to arm usage achieved from years of conventional therapy (physical and occupational therapy) prior to use of the wearable NMES device in this study.
Results
We found that the patients saw an average increase in arm usage from 9.9–43.5% by the end of the study. This result was well represented across age groups and genders, with varying degrees across different diagnoses. Specifically, the TBI subcohort had a consistent increase in arm usage of 5.5% per year over the term of treatment.
Conclusion
This study supports the literature identifying NMES as a therapeutic intervention and complements the literature suggesting that NMES application can be used as a long-term method to increase arm usage in hemiplegic patients.
Dietary pattern and risk of dyslipidemia among pregnant women attending antenatal clinics in Kaduna South LGA, Kaduna State, Nigeria
Authors: Adeniran Sherifat Misbah , Adepoju Oluwafemi Abiodun , Anjuwon Tayo Micheal , Forcados Gilead Ebiegberi , Okola Ijeoma , James Dorcas Bolanle
Published: August 2022

BackgroundMaternal nutrition plays a major role in the outcome of pregnancy. Nutrition and metabolism in pregnancy determine the intrauterine environment, which influences the development of the fetus and a child's health from birth to death. Although dyslipidemia during pregnancy has long-term effects on mother and child, routine antenatal clinic examinations rarely include lipid profile checks. In the present study, we did a cross-sectional investigation on the risk of dyslipidemia and the possible contribution of diet in 130 pregnant women attending antenatal clinics in selected heath facilities in Kaduna South LGA, Kaduna State Nigeria. Both quantitative and qualitative data were collected to assess the risk of dyslipidemia among the pregnant women.ResultsThe pregnant women in this study were between the ages of 16 - 40, 77 % of which had a secondary school education, while 67 % lived on a monthly income of N5,000 - N10,000 (12.05 USD - 24.10 USD). Their diet consisted mainly of fats, oils, and milk and milk products. Indices of dyslipidemia showed that the mean total cholesterol concentration of all the pregnant women (5.73 ± 1.13 mmol/L) was above the optimal range (< 5.20 mmol/L), while more than 10 % of them were above the optimal range for low-density lipoprotein cholesterol, 40.8 % and 35.4 % were at the borderline (1.93 ± 0.14 mmol/L) and high triglycerides (2.74 ± 0.45 mmol/L) concentrations respectively. Only milk and milk products showed a positive relationship with high-density lipoprotein cholesterol (r = 0.999, p = 0.001).ConclusionsThe lipid profiles of pregnant women in our study showed that they were at risk of dyslipidemia. Therefore, routine screening of lipid profiles during antenatal care is important to provide dietitians and caregivers with valuable information on how to provide optimal nutritional care to pregnant women.
Human cytokine receptor CRLF3 is a receptor for the neuroprotective erythropoietin splice variant EV-3
Authors: Knorr Debbra Y , Polo Ignacio Rodriguez , Pies Hanna S , Schwedhelm-Domeyer Nicola , Pauls Stephanie , Behr Rüdiger , Heinrich Ralf
Published: August 2022

Cytokine receptor like factor 3 (CRLF3) is a conserved cytokine receptor present in all major eumetazoan taxa. Though vertebrate CRLF3 has recently been implied in the regulation of hematopoiesis, its ligand remained unidentified. CRLF3 shares structural similarity with receptors for other hematopoietic growth factors including erythropoietin, thrombopoietin and granulocyte colony-stimulating factor. Besides hematopoietic organs, these established hematopoietic cytokines and their receptors are also widely expressed in other tissues including the nervous system, where they regulate proliferation, differentiation, cell survival and other homeostatic processes. Previous studies identified insect CRLF3 as a neuroprotective receptor that can be activated by human recombinant erythropoietin, a widely accepted protective cytokine in vertebrate nervous systems. Epo’s erythropoietic functions mediated by classical Epo receptor are understood in great detail whereas Epo-mediated cytoprotective mechanisms are more complex due to involvement of additional Epo receptors and a splice variant (EV-3) with selectivity for certain unidentified receptors. In the present study, we show that human CRLF3 mediates neuroprotection upon activation with the natural Epo splice variant EV-3. We generated CRLF3 knock out iPSC lines and differentiated them towards the neuronal lineage. While apoptotic death of rotenone-challenged wild type iPSC-derived neurons was prevented by EV-3, EV-3-mediated neuroprotection was absent in CRLF3 knock out neurons. Rotenone-induced apoptosis and EV-3-mediated neuroprotection were associated with differential expression of pro- and anti-apoptotic genes. Our data characterize human CRLF3 as a receptor involved in Epo-mediated neuroprotection and identify CRLF3 as the first known receptor for EV-3.
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Cerita Pecahan Berdasarkan Jenis Kelamin Ditinjau dari Teori Newman
Authors: Lestari Endri Puji , Fiangga Shofan
Published: August 2022

This study research to determine the differences in the types of errors and the cause students' errors in solving fraction story problems by male and female students in terms of Newman's theory. This research is using a qualitative approach to the type of case study. The subjects of this study were 3 male and 3 female students in grade VII MTsN 2 Trenggalek. The selection of research subjects was carried out based on the same mathematical ability and the suitability of gender criteria. The data collection techniques are written tests, unstructured interviews, and documentation. Data analysis techniques are data reduction, data presentation, and conclusion drawing. Based on the results of the study, (1) it was not found that male students and female students made reading errors, (2) male students and female students made comprehension errors with the same percentage, the cause was not writing down what was known and asked, (3) only male students made a transformation errors, the cause was choosing the wrong operation, formula, not converting the problem into mathematical form, (4) male students making process skill errors with a higher percentage than female, the cause was student perform the wrong operations, processes, and calculation results, while female students make mistakes in the process and calculation results, (5) male students make encoding error with higher percentage, the cause was students incorrectly or not writing the final answer.
Predicting the Risk of in-Hospital Mortality in Patients with HIV-Associated Talaromyces Marneffei Infection
Authors: Tat Thanh Nguyen
Published: August 2022

Disseminated Talaromyces marneffei infection (formerly termed penicilliosis) is the third most common microbiologically confirmed opportunistic infection in Southeast Asia, with mortality of up to 30% despite antifungal therapy. There are restrictive clinical algorithms to predict treatment outcomes. A total of 513 patients with microbiology-confirmed HIV-associated talaromycosis were included in the analysis. Poor outcome was observed in 143/513 patients (27.9%). In the univariate logistic regression analysis, hepatomegaly and splenomegaly were protective factors. Shorter duration of illness, higher respiratory rates, dyspnea, AIDS-associated central nervous system syndromes, platelet counts <50,000 cells/mL, aspartate transaminase (AST) >300 U/L, alanine transaminase (ALT) >150 U/L, serum creatinine >110 µmol/L were predictors of poor outcome. In the multivariate logistic regression analysis, shorter days of illness, higher respiratory rates, platelet counts <50,000 cells/mL, AST >300 U/L and serum creatinine >110 µmol/L, active tuberculosis (TB) and/or ongoing TB induction treatment and AIDS-associated central nervous system syndromes were independent predictors of poor outcome. The prognostic scores ranged from 0 to 19, corresponding to a mortality risk of 0% to 100%. The internal validation showed acceptable discrimination (AUC=0.68) and calibration slope (0.93). The Brier score for model performance was 0.14. We developed a simple scoring system that can predict the risk of death in patients with HIV-associated talaromycosis based on routinely measured characteristics on admission. The scoring system will be further externally validated using other cohorts in the region.
An Assessment of Healthcare Relationship Trust between Patent Medicine Vendors and Residents of Hard-to-Reach Settlements in Northern Nigeria
Authors: Ibitoye Oluwasegun John
Published: August 2022

A trusting relationship is required for effective communication between care providers and care seekers, and trust is a determinant of early healthcare-seeking and care outcomes. The patient-Doctor healthcare trust relationship has been widely studied in different settings. However, there is a dearth of information on whether the factors underlying healthcare relationship trust between patients and their doctors are the same as those underlying patients’ trust in other healthcare professionals (including the PPMVs). This study, therefore, aims to assess the level and determinants of healthcare relationship trust between patent medicine vendors and their clients in hard-to-reach settlements in North-western Nigeria. We adapted the revised healthcare relationship trust scale, administered by trained data collectors using android devices. The data were analysed using Stata (version 16). We used the Chi-square test to identify the correlates of the level of trust(high/low), and binary logistic regression was used to identify its determinants. Statistical significance was defined as P<0.05. Slightly above one-quarter (28.1%) of the underserved had high healthcare relationship trust in the PPMVs. Being married, male, residing in a rented or makeshift shelter in Kaduna state, with under-five child(ren) in their household, and self-reporting good health predicted a high level of healthcare relationship trust in PPMVs among the underserved who participated in this study. We concluded that the personal and household characteristics of the underserved could significantly influence their level of trust in PPMV. Therefore, to achieve the aim of improving health outcomes in deprived populations, initiatives seeking to integrate PPMVs into the formal health system in resource-constrained settings should seek to address the determinants of healthcare relationship trust in these populations as part of their rollout process. Keywords: Communities, Hard-to-reach, Healthcare, Trust, Relationship, Workforce.
Social Responsibility Communication In The Context Of The Socialization Function of the Media: An Examination On The Case Of The “Good Stories” Television Program
Authors: KAYA İLHAN Çağla
Published: July 2022

İletişim teknolojilerindeki gelişmelerle birlikte birçok alanda olduğu gibi Kurumsal Sosyal Sorumluluk iletişimi de farklı bir boyut kazanmıştır. Özellikle son yıllarda televizyon programlarında sosyal medya aracılığıyla izleyici ile etkileşimli bir yayın anlayışının kazandığı görünmektedir. Bu durum Kurumsal Sosyal Sorumluluk İletişiminde halkla ilişkiler uygulamalarının televizyona yönelmesine ve yürütülen sosyal sorumluluk faaliyetlerinin geniş kitlelere yayılmasına neden olmuştur. Aynı zamanda toplumda sosyal sorumluluk anlayışının da yaygınlaşmasına neden olan bu gelişmelerle birlikte çeşitli sivil toplum kuruluşları da sosyal sorumluluk faaliyetlerine destek bulabilme fırsatı elde etmektedirler.

Bu kapsamda, çalışmanın temel amacı medyanın kurumsal sosyal sorumluluk iletişimindeki rolünü ortaya koymaktır. Bu amaçla çalışmanın ilk bölümünde tarihsel süreç içerisinde yaşanan sosyal, ekonomik ve toplumsal gelişmelerin kurumsal sosyal sorumluluk kavramının gelişimindeki etkileri ve kurumsal sosyal sorumluluk iletişiminin halkla ilişkiler açısından önemi ele alınmaktadır. Çalışmanın analiz bölümünde ise NTV’de Aralık 2019 ve Mart 2021 arasında yayınlanan “İyi Hikayeler” programı ele alınmaktadır. Bu yolla, KSS uygulamalarının televizyon programlarında işlenmesinin KSS iletişimi açısından sonuçları tartışılmaktadır.
Ciborion Plan Type in Byzantine Religious Architecture Based on Bursa Examples
Authors: SOYKAN A. Nazlı
Published: July 2022

Marmara Denizi’nin güney kıyıları ve bu denize komşu Anadolu’nun kuzeybatısı tarihi kaynaklarda Bithynia olarak adlandırılmaktadır. Başkent’e yakınlığı, önemli ticaret ve sefer yollarının bölgeden geçiyor olması nedeniyle Bithynia, Bizans siyasi ve dini tarihinde büyük bir rol oynamıştır. Bölge, 1. yüzyıldan itibaren Hıristiyanlaşmaya başlamış, sonraki yüzyıllarda Bizans dini yaşamının önemli merkezlerinden biri haline gelmiştir. İznik ve İzmit gibi dini ve siyasi açıdan önemli şehirlerin yanı sıra Gemlik, Mudanya ve Bursa gibi yerleşimler de önemli dini merkezler olmuşlardır. Çalışma konusu Bursa’da kiborion planlı örnekler arasında yer alan, Kumyaka, Başmelekler Kilisesi, Gemlik Kurşunlu Aziz Aberkios Manastırı Kilisesi ve İznik Yenişehir Kapı yakınındaki kilisedir. Öncelikle yapıların mimari tanıtımları çizim ve fotoğraflarla desteklenerek yapılmıştır. Ardından plan tipinin ilk örnek ve dağılımları incelenmiş ve kiborion plan tipinin Bizans dini mimarisindeki yeri belirlenmeye çalışılmıştır.
Amerika Konsolosu Cesnola’nın Kıbrıs’taki Arkeolojik Çalışmaları
Authors: DOĞANÇAY Sungur
Published: July 2022

1865’te Kıbrıs’a Amerika konsolosu olarak atanan Louis Palma di Cesnola, görev yerine gelir gelmez burasını tanımak için çalışmalara başladı. Ada hakkında yeterli malumat sahibi olduktan sonra arkeolojik kazılara başladı. İstanbul ve Kıbrıs’taki Amerikalı siyasilerin destekleri sayesinde çalışmalarını her geçen gün arttırdı. Bu çalışmalar sonunda pek çok tarihi eseri gün yüzüne çıkardı. Her yıl fermanını yeniletmeyi başaran Cesnola bu sayede sorun yaşamadan çalışmalarını devam ettirdi. Fırsat buldukça Kıbrıs’ın kültür ve tabiat varlıklarını Avrupa’nın ve Amerika’nın muhtelif müzelerine gönderdi. Bunlar arasında en önemlileri New York’taki Metropolitan Müzesi, Londra’daki British Museum ve Paris’teki Louvre Müzesi’ydi. Çalışmada Cumhurbaşkanlığı Osmanlı Arşivi’ndeki vesikalar, Cesnola’nın kendi eseri başta olmak üzere konu hakkında bilgi veren kaynaklardan istifade edilerek Cesnola’nın Kıbrıs’taki arkeolojik çalışmaları ve bu çalışmaları sonunda bulduklarını harice kaçırması hakkında bilgi verildi.
Mevduat ve Katılım Bankalarının Likidite Faktörleri
Authors: ÇİFÇİ Gönül
Published: July 2022

Bu çalışmada bazı ekonomi-spesifik ve banka-spesifik değişkenler kullanılarak mevduat ve katılım bankalarının likidite faktörleri incelenmiştir. Sonuçlar mevduat bankalarıın katılım bankalarından daha likit olduğunu göstermiştir. Ancak, ortalama likiditenin her iki banka için de düştüğü görülmüştür. POLS test sonuçları bankaların likiditesinin farklı değişkenlerden etkilendiğini belirtmiştir. Katılım bankaları için RSF, EM, MGT, RWA ve GDPGrowth değişkenleri %90 anlamlılık derecesinde anlamlıdır. GDPGrowth tek ekonomi-spesifik değişkendir. Katılım bankaları için RSF en az MGT ise en etkili faktör olarak belirlenmiştir. Diğer yandan, RSF ve MGT banka likiditesi ise ters yölü bir ilişki göstermektedir. Mevduat bankalarında FLP, M3, CPI, ROA, ve FINANCE %95 anlamlılık düzeyinde anlamlı bulunmuşlardır. Ancak, tüm bu değişkenler mevduat bankaları likiditesi ile ters yönlü bir ilişkiye sahiptirler.
H. G. WELLS’İN THE SLEEPER AWAKES ROMANININ TOPLUMSAL EKOLOJİK OKUMASI
Authors: ALTAÇ İsmail Serdar
Published: July 2022

H. G. Wells, one of the pioneering utopian and dystopian authors of the late Victorian Age, delineates a political conjuncture into which London and the rest of the world may evolve two centuries later. The novel depicts a future in which the working class is socially oppressed in a new order where a world government that holds the reign of power globally and capitalism has gained an ultimate victory historically. Moreover, in this dystopic representation, the social life in the countryside has ended and the whole population is concentrated in the city. This study aims to demonstrate that, in The Sleeper Awakes, the mechanism of domination does not only have a formative power in the social sphere but also is extended towards nature. Furthermore, it is manifested that the domination over these two spheres is far from being independent of each other; on the contrary, they are mutually supportive processes. In this context, this paper uses social ecology, led by Murray Bookchin, as the theoretical framework in reading the novel. Departing from this theory, the reasons for the alienation of second nature from first nature, and the political and social outcomes of this alienation in the work have been demonstrated. Correspondingly, the implications of the centralization of both the population and political power with respect to human-nature relationships have been delved into. In addition to these, nature is shown to be objectified within a hierarchical web of relations in a system that cements the social hierarchies. Thus, this study puts forward that The Sleeper Awakes, a text that foregrounds the ideological and political discussions, may also address the ecological preoccupations.
Safeviler’de Dönüşüm Sembolü Olarak Başkentler: Kazvin ve İsfahan
Authors: BAHARLU İlgar
Published: July 2022

Safevi Devleti’nin yaklaşık iki buçuk asırlık ömrü boyunca, manevi başkenti mahiyetinde olan Erdebil dışında üç şehir bu devlete başkentlik etmiştir. Bu şehirlerden Tebriz ve Kazvin tarihî Azerbaycan sınırları içerisindeyken, üçüncü başkent yani İsfahan ise Acem bölgesinde yer almıştır. Bu başkentlerin seçiminde dönemin siyasî, itikadî, sosyokültürel ve ekonomik şartlar belirleyici olmuştur. Devletin sınırları ve bu sınırlara göre rakip veya düşman olan komşulara yakınlığı, bölgedeki nüfus ağırlığı ve bu nüfusun etnik, itikadî ve kültürel özellikleri, dönemin ekonomik şartları ve ticaret rotaları başkentlerin seçilmesi veya değiştirilmesinde önemli rol oynamıştır.

Bu çalışmada Kazvin’in Şah Tahmasb tarafından başkent seçilmesi ve ardından I. Şah Abbas (1587-1629) döneminde başkentin Kazvin’den İsfahan’a taşınmasının nedenlerini ele alınmaktadır. Bu doğrultuda, kronikler ve seyahatnameler eşliğinde ve ayrıca konu ile ilgili çalışma yapan muasır araştırmacıların fikir ve çıkarımlarına yer verilerek Kazvin’in Tebriz’e göre avantajları ve Tebriz’in söz konusu dönemde dezavantajları ele alınmış, devamında ise Safevi Devleti’nin son başkenti olan İsfahan, aynı yöntemle mütalaaya konu edinilmiştir.

Çalışma sonucunda görülen şu ki söz konusu iki başkentin seçiminde siyasî, ekonomik, coğrafi şartlar, askeri gerekçeler ve tabi sultanların şahsî hassasiyetleri önemli rol oynamaktadır. Bunun yanı sıra her iki sultanın -Tahmasb ve I. Şah Abbas- bu kararlarında, Kızılbaşlar ve elbette bu zümrelerin inancı ve bu inanca mensup zümrelerin ülkedeki tutum, davranış ve gücü de önemli faktörlerden olmuştur. Başka bir deyimle yukarda zikredilen sebeplerin yanı sıra dönemin itikadî özellikleri ve bu itikadın temsilcilerinin devlette oynadıkları rolün de göz önünde bulundurulması gerekmektedir.
Artifical Intelligence (AI) Technology in Smart Tourism
Authors: BAŞER Miraç Yücel , OLCAY Atınç
Published: July 2022

Teknolojide yaşanan gelişmelerin insan zekâsını taklit eden yeni nesil yapay zekâ uygulamalarını ortaya çıkardığı bilinmektedir. Ekonomi, sağlık, eğitim gibi hayatın bir çok alanında kullanılan yapay zekâ teknolojilerinin, değişen tüketici kalıpları neticesinde turizm sektörü içinde önemli olmaya başladığı görülmektedir. Çünkü yapay zekâ uygulamaları turistler açısından gerek zaman gerek ekonomik faydalar sunan uygulamalar olmaktadır. Yapay zekâ teknolojilerine odaklan bu çalışmada akıllı turizm kapsamında hangi yapay zekâ teknolojisinin nasıl kullanılabileceğinin belirlenmesi amaçlanmaktadır. Bu amaçla hazırlanan çalışmada Web 3.0 ile birlikte gelişme gösteren blok zincir tabanlı uygulamalara da değinilerek hangi yapay zekâ teknolojisi yerine kullanılabileceği de ifade edilmeye çalışılmıştır.
CANDIDATE IMAGE IN LOCAL ELECTİONS: THE CASE OF GAZİANTEP
Authors: ŞAHAN Süleyman , CİNKARA Yusuf
Published: July 2022

Siyasetin dönüşen yapısı içerisinde kişiselleşme ögesinin belirginleşmesiyle birlikte seçmen davranışlarının açıklanmasında en sık başvurulan kavramlardan biri de aday imajıdır. Aday imajı seçmenlerin karar verme süreçlerinin soyut ve kompleks görünümünü somutlaştırarak anlamlandıran bir kavram haline gelmiştir. Bu bağlamda araştırmanın amacı, seçmenlerin zihinlerinde aday imajı oluştururken hangi faktörlerden etkilendiklerini ortaya koymaktır. Gaziantep ilinde 390 katılımcıyla gerçekleştirilen çalışmada Medya, İletişim, Kişisel özellikler, Tecrübe, Dış Görünüş, Parti ve Sosyo-Kültürel Özelliklerinden oluşan aday imajı ölçeği kullanılmıştır. Bu faktörler arasında aritmetik ortalama değer bakımından seçmenlerin en fazla önem verdiği faktör, adayın dürüst ve güvenilir olması, çalışkan olması ve samimi olması özelliklerinden oluşan Kişisel Özellikler’dir. Katılımcıların yerel seçimlerde tercihte bulunurken en az önem verdikleri faktör ise dış görünüş faktörüdür. Seçmenlerin zihinlerindeki aday imajını oluşturan faktörleri algılayışları; onların cinsiyetine, yaşına, eğitim durumuna, gelirine, mesleğine, siyasal konumuna, ideolojik kimliğine, oy verdiği partiye, oy verme karar zamanına, oy verme gerekçesine, parti bağlılığına ve siyasal konulara ilgi düzeyine göre farklılaşmaktadır.