bluuebunny/crossref_metadata_2025 huggingface dataset:
TRPC Channels As Effectors of Cardiac Hypertrophy
Authors: Eder Petra , Molkentin Jeffery D.
Published: January 2011

Transient receptor potential (TRP) channels of multiple subclasses are expressed in the heart, although their functions are only now beginning to emerge, especially for the TRPC subclass that appears to regulate the cardiac hypertrophic response. Although TRP channels permeate many different cations, they are most often ascribed a specific biological function because of Ca
2+
influx, either for microdomain signaling or to reload internal Ca
2+
stores in the endoplasmic reticulum through a store-operated mechanism. However, adult cardiac myocytes arguably do not require store-operated Ca
2+
entry to regulate sarcoplasmic reticulum Ca
2+
levels and excitation–contraction coupling; hence, TRP channels expressed in the heart most likely coordinate signaling within local domains or through direct interaction with Ca
2+
-dependent regulatory proteins. Here, we review the emerging evidence that TRP channels, especially TRPCs, are critical regulators of microdomain signaling in the heart to control pathological hypertrophy in coordination with signaling through effectors such as calcineurin and NFAT (nuclear factor of activated T cells).
Vascular Calcification in Chronic Renal Failure
Authors: Neven Ellen , D'Haese Patrick C.
Published: January 2011

Accelerated atherosclerotic plaque calcification and extensive medial calcifications are common and highly detrimental complications of chronic kidney disease. Valid murine models have been developed to investigate both pathologically distinguishable complications, which allow for better insight into the cellular mechanisms underlying these vascular pathologies and evaluation of compounds that might prevent or retard the onset or progression of vascular calcification. This review describes various experimental models that have been used for the study of arterial intimal and/or medial calcification and discusses the extent to which this experimental research has contributed to our current understanding of vascular calcification, particularly in the setting of chronic renal failure.
Disenfranchisement of Countries and Civil Society at COP-15 in Copenhagen
Authors: McGregor Ian M.
Published: January 2011

Civil society organizations were disenfranchised, as were many countries, at COP-15 in Copenhagen in December 2009. The main forces that contributed to this disenfranchisement were not, however, increased registration and the merging of movements within civil society. Poor planning did contribute to the disenfranchisement; however, in cooperation with state actors, this was also to some extent overcome at COP-15. The unusual process by which the Copenhagen Accord was developed did disenfranchise civil society and many countries. Major concerns regarding the undemocratic nature of this process and the inadequacy of the Accord were raised by some countries in the final plenary of COP-15. These countries were backed by a number of civil society organizations that had already denounced the Accord as a non-deal, contributing to the COP not adopting the Accord as a formal decision. The Accord's existence was eventually only noted by the final COP-15 plenary, reflecting this widespread disaffection.
Murine TMJ Loading Causes Increased Proliferation and Chondrocyte Maturation
Authors: Sobue T. , Yeh W.-C. , Chhibber A. , Utreja A. , Diaz-Doran V. , Adams D. , Kalajzic Z. , Chen J. , Wadhwa S.
Published: January 2011

The purpose of this study was to examine the effects of forced mouth opening on murine mandibular condylar head remodeling. We hypothesized that forced mouth opening would cause an anabolic response in the mandibular condylar cartilage. Six-week-old female C57BL/6 mice were divided into 3 groups: (1) control, (2) 0.25 N, and (3) 0.50 N of forced mouth opening. Gene expression, micro-CT, and proliferation were analyzed. 0.5 N of forced mouth opening caused a significant increase in mRNA expression of Pthrp, Sox9, and Collagen2a1, a significant increase in proliferation, and a significant increase in trabecular spacing in the subchondral bone, whereas 0.25 N of forced mouth opening did not cause any significant changes in any of the parameters examined. Forced mouth opening causes an increase in the expression of chondrocyte maturation markers and an increase in subchondral trabecular spacing.
Cleft Lip with Cleft Palate, Ankyloglossia, and Hypodontia are Associated with TBX22 Mutations
Authors: Kantaputra P.N. , Paramee M. , Kaewkhampa A. , Hoshino A. , Lees M. , McEntagart M. , Masrour N. , Moore G.E. , Pauws E. , Stanier P.
Published: January 2011

X-linked cleft palate and ankyloglossia (CPX) are caused by mutations in the TBX22 transcription factor. To investigate whether patients with ankyloglossia alone or in the presence of other craniofacial features including hypodontia or CLP might be caused by TBX22 mutations, we analyzed 45 Thai patients with isolated ankyloglossia, 2 unusual CPA families, and 282 non-syndromic Thai and UK patients with CLP. Five putative missense mutations were identified, including 3 located in the T-box binding domain (R120Q, R126W, and R151L) that affects DNA binding and/or transcriptional repression. The 2 novel C-terminal mutations, P389Q and S400Y, did not affect TBX22 activity. Mutations R120Q and P389Q were identified in patients with ankyloglossia only, while R126W and R151L were present in families that included CLP. Several individuals in these families were also found to have micro/hypodontia. This study has expanded the phenotypic spectrum of TBX22-related mutations to include dental anomalies and cleft lip.
Cysteine Cathepsins in Human Carious Dentin
Authors: Nascimento F.D. , Minciotti C.L. , Geraldeli S. , Carrilho M.R. , Pashley D.H. , Tay F.R. , Nader H.B. , Salo T. , Tjäderhane L. , Tersariol I.L.S.
Published: January 2011

Matrix metalloproteinases (MMPs) are important in dentinal caries, and analysis of recent data demonstrates the presence of other collagen-degrading enzymes, cysteine cathepsins, in human dentin. This study aimed to examine the presence, source, and activity of cysteine cathepsins in human caries. Cathepsin B was detected with immunostaining. Saliva and dentin cysteine cathepsin and MMP activities on caries lesions were analyzed spectrofluorometrically. Immunostaining demonstrated stronger cathepsins B in carious than in healthy dentin. In carious dentin, cysteine cathepsin activity increased with increasing depth and age in chronic lesions, but decreased with age in active lesions. MMP activity decreased with age in both active and chronic lesions. Salivary MMP activities were higher in patients with active than chronic lesions and with increasing lesion depth, while cysteine cathepsin activities showed no differences. The results indicate that, along with MMPs, cysteine cathepsins are important, especially in active and deep caries.
Maternal Oral Health Predicts Their Children’s Caries Experience in Adulthood
Authors: Shearer D.M. , Thomson W.M. , Broadbent J.M. , Poulton R.
Published: January 2011

The long-term effects of poor maternal oral health are unknown. We determined whether maternal oral health when children were young was a risk indicator for caries experience in adulthood, using oral examination and interview data from age-5 and age-32 assessments in the Dunedin Study, and maternal self-rated oral health data from the age-5 assessment. The main outcome measure was probands’ caries status at age 32. Analyses involved 835 individuals (82.3% of the surviving cohort) dentally examined at both ages, whose mothers were interviewed at the age-5 assessment. There was a consistent gradient in age-32 caries experience across the categories of maternal self-rated oral health status (from the age-5 assessment): it was greatest among the probands whose mothers rated their oral health as “poor” or who were edentulous, and lowest among those whose mothers rated their oral health as “excellent”. Unfavorable maternal self-rated oral health when children are young should be regarded as a risk indicator for poor oral health among offspring as they reach adulthood.
Influence of Experimental Esophageal Acidification on Sleep Bruxism
Authors: Ohmure H. , Oikawa K. , Kanematsu K. , Saito Y. , Yamamoto T. , Nagahama H. , Tsubouchi H. , Miyawaki S.
Published: January 2011

The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy adult males without SB participated. Intra-esophageal infusions of 5-mL acidic solution (0.1 N HCl) or saline were administered. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-minute period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification. This trial is registered with the UMIN Clinical Trials Registry, UMIN000002923. Abbreviations: ASDA, American Sleep Disorders Association; EMG, electromyogram; GER, gastroesophageal reflux; LES, lower esophageal sphincter; NREM, non-rapid eye movement; REM, rapid eye movement; RMMA, rhythmic masticatory muscle activity; SB, sleep bruxism; SD, standard deviation; UES, upper esophageal sphincter.
Modeling and simulation of water distribution systems using timed hybrid Petri nets
Authors: Gudiño-Mendoza Berenice , López-Mellado Ernesto , Alla Hassane
Published: January 2011

This paper deals with modeling and simulation of water distribution systems using Hybrid Petri Nets. A methodology for building a Timed Hybrid Petri Net (THPN) model is proposed; the model is derived from a set of equations describing conservation of mass and energy that specify the behaviour of a water distribution network. A simulation technique for the execution of a THPN in which the transitions firing velocities are established from the linearised conservation of energy equations is presented; it shows both transient and steady state for the analysis of hydraulic networks. Based on this technique, a simulator in Matlab has been developed.
The comfort, energy and health implications of London’s urban heat island
Authors: Mavrogianni A. , Davies M. , Batty M. , Belcher SE , Bohnenstengel SI , Carruthers D. , Chalabi Z. , Croxford B. , Demanuele C. , Evans S. , Giridharan R. , Hacker JN , Hamilton I. , Hogg C. , Hunt J. , Kolokotroni M. , Martin C. , Milner J. , Rajapaksha I. , Ridley I. , Steadman JP , Stocker J. , Wilkinson P. , Ye Z.
Published: January 2011

The urban heat island (UHI) is a well-known effect of urbanisation and is particularly important in world megacities. Overheating in such cities is expected to be exacerbated in the future as a result of further urban growth and climate change. Demonstrating and quantifying the impact of individual design interventions on the UHI is currently difficult using available software tools. The tools developed in the LUCID (‘The Development of a Local Urban Climate Model and its Application to the Intelligent Design of Cities’) research project will enable the related impacts to be better understood, quantified and addressed. This article summarises the relevant literature and reports on the ongoing work of the project.

Practical applications: There is a complex relationship between built form, urban processes, local temperature, comfort, energy use and health. The UHI effect is significant and there is a growing recognition of this issue. Developers and planners are seeking advice on design decisions at a variety of scales based on scientifically robust, quantitative methods. The LUCID project has thus developed a series of tools that (1) quantify the effect of urbanisation processes on local environmental conditions, and (2) quantify the impact of such conditions on comfort, energy use and health. The use of such tools is vital, both to inform policy but also to be able to demonstrate compliance with it.
Spontaneous retrograde dissection of ascending aorta from descending thoracic aorta - a case review
Authors: Kaul Pankaj
Published: January 2011

A 56-year-old man with sudden onset chest pain, absent right lower limb pulses and ECG changes suggestive of inferior ST elevation MI underwent coronary angiogram through the right radial artery with a view to primary percutaneous coronary intervention (PCI). The left coronary angiogram demonstrated severe proximal stenotic disease in the left anterior descending and circumflex coronary arteries, but the right coronary artery could not be selectively cannulated. An ascending aortogram to visualise the right coronary artery not only failed to demonstrate it, but revealed, instead, a dissection flap in the ascending aorta, arch and descending thoracic aorta, with moderately severe aortic regurgitation. At operation, the patient was found to have an acute dissection of the ascending aorta, arch and descending aorta with an entry tear in the descending aorta below the left subclavian artery origin. Triple coronary artery bypass grafting with re-suspension of the aortic valve, supracoronary replacement of the ascending aorta and hemiarch and transaortic repair of the descending aortic tear was performed. The patient made an uncomplicated recovery, with the re-appearance of right limb pulses. A postoperative magnetic resonance (MR) scan revealed complete thrombosis of the false channel in the residual arch and a considerably shrunken false channel in the descending aorta and no aortic regurgitation.

Retrograde dissection of the ascending aorta from the descending aorta has been reported infrequently in the past. We believe the scale of the problem has been underestimated because of the failure to adopt open distal anastomosis routinely in the past and, hence, failure to inspect the arch and the descending aorta routinely, particularly when the intimal tear was not identified in the ascending aorta. Retrograde dissection of the ascending aorta from an intimal tear in the descending aorta, when identified as such, has been managed, either on the principle of exclusion of the tear in the descending aorta by various elephant trunk procedures and their variants or, alternatively, on the principle of excision of the tear by extended one-stage aortic replacement, usually combined with an elephant trunk procedure. Neither of these procedures is widely adopted, owing to procedural, institutional and outcome considerations. We describe a transaortic repair of the intimal tear in the descending aorta with supracoronary interposition graft replacement of the ascending aorta and hemiarch with excellent clinical and radiological result. We also review the diagnostic and therapeutic approaches to this incompletely understood lethal disease.
The importance of the conus artery in patients with obstructive coronary artery disease
Authors: Karabay Can Yucel , Aung Soe Moe , Tanboga Ibrahim Halil , Kalayci Arzu , Kocabay Gönenc , Güler Ahmet , Candan Ozkan , Kirma Cevat
Published: January 2011

It is well-known that collateral circulation is important in preserving ventricular functions, especially in coronary artery disease with total occlusion. The conus branch is distinct in having notable capacity of angiogenesis and arteriogenesis. We intend to emphasize the clinical importance of the conus branch by presenting two cases in which it supplied the distal regions of total occlusion.
Evaluation of two pediatric polymethyl pentene membrane oxygenators with pulsatile and non-pulsatile perfusion
Authors: Feng Qiu  , Khan Sameer , Talor Jonathan , Kunselman Allan , Ündar Akif
Published: January 2011

Objectives: This experiment sought to compare two polymethyl pentene (PMP) hollow-fiber membrane oxygenators: the Medos HILITE 2400 LT and the Maquet Quadrox-iD Pediatric in terms of transmembrane pressure gradients and hemodynamic energy preservation under both pulsatile and non-pulsatile conditions.

Methods: A simulated pediatric extracorporeal life support (ECLS) circuit was used to test these two oxygenators. The circuit consisted of a roller pump, ¼ inch tubing for both arterial and venous lines, an oxygenator, and a venous reservoir served as a pseudo-patient. Three pressure transducers were placed upstream and downstream of the oxygenator and the distal arterial line. The experimental system was primed with lactated Ringer’s solution and packed human red blood cells to maintain a hematocrit of 40%.The total volume was 600 ml, including the 350 ml volume of the pseudo-patient.The tests were performed at six flow rates (250, 500, 750, 1000, 1250, 1500 ml/min) and three distal arterial line pressures (MAP) (60, 80, 100 mmHg), under both pulsatile and non-pulsatile perfusion modes.The temperature was kept constant at 37°C for all tests.

Results: Both oxygenators had adequate performances in pressure drop and hemodynamic energy preservation. There were no significant differences between pre- and post-oxygenators for mean pressure (MP), energy equivalent pressure (EEP) and total hemodynamic energy (THE). During the pulsatile perfusion mode, the HILITE 2400 LT retained a greater percentage of surplus hemodynamic energy (SHE) across the oxygenator.

Conclusions: Both the Quadrox-iD Pediatric and HILITE 2400LT PMP membrane oxygenators are suitable for pediatric ECLS therapy under both non-pulsatile and pulsatile perfusion. An optimized combination of flow rate and MAP should be achieved in order to deliver the maximal pulsatile energy in the extracorporeal circuit.
Counterhegemonic currents and internationalization of sociology
Authors: Keim Wiebke
Published: January 2011

This article deals with the position of the Southern sociologies within the discipline. The role and presence of local, national and regional scholarly communities has been widely reflected on in the context of the discussion around internationalization or globalization of the discipline. Thus, a variety of critiques of ‘Eurocentrism’, or more precisely, ‘North Atlantic domination’, have arisen in recent years that can be strengthened by empirical evidence of strong inequalities and distorted communication mechanisms within sociology at an international level. What has been largely missing so far is the demonstration of viable alternatives to North Atlantic domination, as well as enquiries into the conditions of their emergence. This article offers a different perspective by highlighting counterhegemonic currents emerging out of the South despite the peripheral position, i.e. by drawing attention towards challenging scholarly communities and their output that have not received much, if any, attention in the discussions so far.
The role of social contacts in the employment status of immigrants
Authors: Kanas Agnieszka , van Tubergen Frank , Van der Lippe Tanja
Published: January 2011

Several studies in the migration literature have hypothesized that social contacts, in particular contacts with natives, are important for immigrant employment. Empirical work, however, has been inconclusive whether social contacts indeed have a causal effect. This study uses the German Socio-Economic Panel (1984—2004) to estimate the effect of social contacts of male and female immigrants on their employment position. Results show that contacts with family, friends and neighbours and being active as a volunteer have no significant effect on employment for both immigrant men and women. It is also found that having contacts with Germans increases the likelihood of male and female employment. The positive effect of having German contacts remains when social contacts are lagged, when host-country human capital is taken into account and also when unmeasured time-constant characteristics of immigrants are considered.
Between a gender and a feminist analysis
Authors: Sa'ar Amalia , Sachs Dalia , Aharoni Sarai
Published: January 2011

This article argues that professional literature on national security in Israel, especially during the second Intifada (2000—4), reinforced the invisibility of a range of insecurities informing the lives of women and members of marginalized groups. The authors discuss the problematic of using ‘gender’ without a feminist perspective and examine the challenges of incorporating the latter into quantitative studies of security, then briefly present their research on women under a situation of political turmoil in Israel to offer intersectionality as a possible resolution. Instead of focusing on (and reifying) differences between women and men, this study located complexity in variations among women by intersecting different social locations, different types of violence and different types of knowledge. The discussion highlights the contribution of intersectionality to overcoming essentialist explanations of women’s insecurities during armed conflicts.
Authentic self-realization and depression
Authors: Petersen Anders
Published: January 2011

The central point of this article is that the burgeoning depression rates of our day may be understood in relation to the normative demand for self-realization with which contemporary western individuals are confronted. The article argues that the expectation of lasting fulfilment of authentic self-realization may be regarded as a chronic stress factor for the individual and risks creating depression. The modern view of depression supports this perspective. Depression is today regarded as the precise opposite of successful self-realization, and consequently, as a repression of life’s possibilities for self-realization. The article also discusses how treatment with antidepressants fits into this interpretive frame — how antidepressants can be regarded as a kind of action technique which can support the individual in attempts to realize his or her authentic self. Finally, the article discusses the possible problems which may arise from this treatment approach.
Is levomepromazine stable over time?
Authors: Hardy J , O’Shea A , Gilbert C , Norris R
Published: January 2011

Levomepromazine (methotrimeprazine) is an anti-psychotic used at low dose for the control of nausea and vomiting. When levomepromazine hydrochloride as Nozinan® is diluted with 0.9% sodium chloride at concentrations ranging from 0.13 to 6.25 mg/ml, and stored in polypropylene syringes, the drug is stable for at least 14 days.
What does the answer mean? A qualitative study of how palliative cancer patients interpret and respond to the Edmonton Symptom Assessment System
Authors: Bergh Irmelin , Kvalem Ingela Lundin , Aass Nina , Hjermstad Marianne Jensen
Published: January 2011

The Edmonton Symptom Assessment System (ESAS) is a well-known self-reporting tool for symptom assessment in palliative care. Research has shown that patients experience difficulties in the scoring and interpretation, which may lead to suboptimal treatment. The aims were to examine how palliative care cancer patients interpreted and responded to the ESAS. Eleven patients (3 F/8 M), median age 65 (34–95) with mixed diagnoses were interviewed by means of cognitive interviewing, immediately after having completed the ESAS. The highest mean scores were found with tiredness (6.3) and oral dryness (5.7). The results showed that sources of error were related to interpretation of symptoms and differences in the understanding and use of the response format. The depression and anxiety symptoms were perceived as difficult to interpret, while the appetite item was particularly prone to misunderstandings. Contextual factors, such as mood and time of the day, influenced the answers. Lack of information and feedback from staff influenced the scores. Some patients stated that they scored at random because they did not understand why and how the ESAS was used. The patients’ interpretation must be considered in order to minimize errors. The ESAS should always be reviewed with the patients after completion to improve symptom management, thereby strengthening the usability of the ESAS.
Does place of death from cancer vary between ethnic groups in South East England?
Authors: Coupland Victoria H , Madden Peter , Jack Ruth H , Møller Henrik , Davies Elizabeth A
Published: January 2011

There is growing evidence that the palliative care needs of certain people, such as those from minority ethnic groups, are not being met. The aim of this study was to investigate whether place of death from cancer differs between ethnic groups. A total of 101,516 patients resident in South East England and who died from lung, colorectal, breast or prostate cancer between 1998 and 2006 were extracted from the Thames Cancer Registry database. Ethnicity data were available for 68,804 patients (68%). The odds ratios (ORs) of death from cancer in a hospice, at home or in hospital were calculated. The results were adjusted for age at death, deprivation, cancer network of residence and time between diagnosis and death. Following adjustment, death in a hospice was significantly less likely for Pakistani patients (OR = 0.47 95% CI [0.30–0.74]), Indian patients (0.68 [0.55–0.84]) and Bangladeshi patients (0.33 [0.19–0.56]). Death at home was significantly less likely in Black African patients (0.48 [0.36–0.65]), Black Caribbean patients (0.78 [0.67–0.90]) and Chinese patients (0.46 [0.28–0.76]). Pakistani, Indian, Bangladeshi, Black African, Black Caribbean and Chinese patients were all significantly more likely than White patients to die in hospital. The results were not substantially altered by recoding the unknown ethnicity group to White or using multiple imputation to assign those with a missing ethnicity an ethnic group. Place of death varies between ethnic groups. This may reflect differences in preferences for place of death or barriers to accessing specialist care in different settings. More detailed prospective qualitative studies are urgently required to determine reasons for this variation.
Withdrawal of mechanical ventilation in the home: A case report and review of the literature
Authors: Clinch Alexandra , Le Brian
Published: January 2011

Once it has been determined that aggressive medical treatment can no longer meet the goals of care for a ventilated patient, the process of withdrawing mechanical ventilation begins. This is a challenging clinical situation, drawing on the treating physician's skills including clinical decision making with consideration of the ethical and legal domains of practice, high level communication skills, intensive symptom control for the dying patient, and support for families throughout the episode, including bereavement. Central to the success of this process is recognition and respect for the needs and wishes of the patient and family. This case reports on the withdrawal of mechanical ventilation from a conscious patient in their own home, leading to death, following a prolonged hospital admission.
Seasonal and Diel Variation of Hormone Metabolites in European Stonechats: On the Importance of High Signal-to-Noise Ratios in Noninvasive Hormone Studies
Authors: Goymann Wolfgang , Trappschuh Monika
Published: January 2011

Most vertebrates living in seasonal environments show seasonal reproductive cycles and diel rhythms. The rhythmicity in behavior and morphology is accompanied by diel and seasonal patterns of hormone secretions. In small animals, the investigation of diel patterns of hormones has been hampered because repeated blood sampling is difficult and may influence subsequent measurements. A possibility to avoid these caveats is to investigate excreted hormone metabolites instead. Here, we describe the diel excretion patterns of testosterone and corticosterone metabolites in a small captive songbird during 4 seasons: winter, early spring ( Zugunruhe), summer, and autumn molt. Our approach is quite unique, because the diel patterns of steroids have rarely—if at all—been investigated in the same individuals within several seasons. Small birds should be ideal to investigate diel patterns of hormone metabolites, because they defecate frequently enough to establish a diel profile. However, concentration measurements of hormone metabolites rely on the assumptions that hormone metabolites are placed into droppings of similar mass (the “dropping amount assumption”) and are excreted in constant time intervals (the “constant interval assumption”). These assumptions were clearly violated in our study, as the dropping mass per time interval and the defecation intervals varied depending on the time of day and season. We thus used the rate of hormone metabolite excretion as an alternative measure to concentration. Both testosterone and corticosterone metabolites showed diel and seasonal rhythmicity. Furthermore, the diel pattern varied depending on season. Concentration and rate measurements gave similar results when the differences between hormone metabolite levels were large—for example, when testosterone metabolites were compared across seasons. When the differences were more subtle, though, the 2 measures did not always correspond well, indicating that the violation of the 2 basic assumptions affected the comparability of concentration measurements. We conclude that diel and seasonal comparisons of hormone metabolites potentially give biologically meaningful results, especially when rates instead of concentrations are measured. However, such studies require awareness of the limitations and pitfalls of noninvasive hormone measurements, a carefully designed experiment, and very cautious interpretation of the data.
Acute Light Exposure Suppresses Circadian Rhythms in Clock Gene Expression
Authors: Grone Brian P. , Chang Doris , Bourgin Patrice , Cao Vinh , Fernald Russell D. , Heller H. Craig , Ruby Norman F.
Published: January 2011

Light can induce arrhythmia in circadian systems by several weeks of constant light or by a brief light stimulus given at the transition point of the phase response curve. In the present study, a novel light treatment consisting of phase advance and phase delay photic stimuli given on 2 successive nights was used to induce circadian arrhythmia in the Siberian hamster ( Phodopus sungorus). We therefore investigated whether loss of rhythms in behavior was due to arrhythmia within the suprachiasmatic nucleus (SCN). SCN tissue samples were obtained at 6 time points across 24 h in constant darkness from entrained and arrhythmic hamsters, and per1, per2 , bmal1, and cry1 mRNA were measured by quantitative RT-PCR. The light treatment eliminated circadian expression of clock genes within the SCN, and the overall expression of these genes was reduced by 18% to 40% of entrained values. Arrhythmia in per1, per2, and bmal1 was due to reductions in the amplitudes of their oscillations. We suggest that these data are compatible with an amplitude suppression model in which light induces singularity in the molecular circadian pacemaker.
Pigment-Dispersing Factor Affects Nocturnal Activity Rhythms, Photic Entrainment, and the Free-Running Period of the Circadian Clock in the Cricket Gryllus bimaculatus
Authors: Hassaneen Ehab , El-Din Sallam Alaa , Abo-Ghalia Ahmad , Moriyama Yoshiyuki , Karpova Svetlana G. , Abdelsalam Salah , Matsushima Ayami , Shimohigashi Yasuyuki , Tomioka Kenji
Published: January 2011

Pigment-dispersing factor (PDF) is a neuropeptide widely distributed in insect brains and plays important roles in the circadian system. In this study, we used RNA interference to study the role of the pigment-dispersing factor ( pdf) gene in regulating circadian locomotor rhythms in the cricket, Gryllus bimaculatus. Injections of pdf double-stranded RNA (ds pdf) effectively knocked down the pdf mRNA and PDF peptide levels. The treated crickets maintained the rhythm both under light-dark cycles (LD) and constant darkness (DD). However, they showed rhythms with reduced nocturnal activity with prominent peaks at lights-on and lights-off. Entrainability of ds pdf-injected crickets was higher than control crickets as they required fewer cycles to resynchronize to the LD cycles shifted by 6 h. The free-running periods of the ds pdf-injected crickets were shorter than those of control crickets in DD. These results suggest that PDF is not essential for the rhythm generation but involved in control of the nocturnality, photic entrainment, and fine tuning of the free-running period of the circadian clock.
Temperature Entrainment of the Circadian Cuticle Deposition Rhythm in Drosophila melanogaster
Authors: Ito Chihiro , Goto Shin G. , Tomioka Kenji , Numata Hideharu
Published: January 2011

The cuticle deposition rhythm, which is observed in the apodeme of the furca in the thorax, is controlled by a peripheral circadian clock in the epidermal cells and entrained to light-dark (LD) cycles via CRYPTOCHROME (CRY) in Drosophila melanogaster. In the present study, we examined the effects of temperature (TC) cycles and the combination of LD and TC cycles on entrainment of the cuticle deposition rhythm. The rhythm was entrained to TC cycles, whose period was 28 h. In T = 21 and 24 h, the rhythm was entrained to TC cycles in some individuals. CRY is not necessary for temperature entrainment of the cuticle deposition rhythm because the rhythm in cryb (lacking functional CRY) was entrained to TC cycles. Temperature entrainment of the rhythm was achieved even when the thoraxes or furcae were cultured in vitro, suggesting that the mechanism for temperature entrainment is independent of the central clock in the brain and the site of the thermoreception resides in the epidermal cells. When LD and TC cycles with different periods were applied, the rhythm was entrained to LD cycles with a slight influence of TC cycles. Thus, the LD cycle is a stronger zeitgeber than the TC cycle. The variance of the number of the cuticle layers decreased in the flies kept under LD and TC cycles with the same period in which the thermophase coincided with the photophase. Therefore, we conclude that LD and TC cycles synergistically entrain the rhythm. Synergistic effects of LD and TC cycles on entrainment were also observed even when the thoraxes were cultured in vitro, suggesting that the light and temperature information is integrated within the peripheral circadian system.
Correlated Fluctuations of Daytime Skin Temperature and Vigilance
Authors: Romeijn Nico , Van Someren Eus J. W.
Published: January 2011

Skin temperature shows spontaneous ultradian fluctuations during everyday-life wakefulness. Previous work showed that mild manipulations of skin temperature affect human sleep and vigilance, presumably by influencing neuronal systems involved in both thermal sensing and arousal regulation. We therefore examined whether fluctuations in skin temperature are associated with those in vigilance level under conditions similar to everyday-life situations requiring sustained attention. Eight healthy participants (30.1 ± 8.1 years, M ± SD) participated in a 2-day protocol, during which vigilance and skin temperature were assessed 4 times per day in a silent, dimly lit, temperature-controlled room. Vigilance was assessed by measuring reaction speed and lapses on a novel sustained vigilance task specifically designed to increase lapse rate and range of reaction times. Skin temperature was sampled at 30-second intervals from 3 locations: distal, intermediate, and proximal temperatures were obtained from the middle finger (Tfinger ), the wrist (Twrist), and the infraclavicular area (Tchest), respectively. Furthermore, 3 distal to proximal gradients were calculated. Mixed-effect regression analyses were used to evaluate the association of the fluctuations in temperatures and gradients and those in response speed and lapse probability. Especially the spontaneous fluctuations in proximal temperature were negatively associated with fluctuations in response speed and positively with lapse rate. If individual Tchest temperature ranges were classified into 10 deciles, they accounted for 23% of the variance in response speed and 11% of the variance in lapse rate. The findings indicate coupling between the spontaneous fluctuations in skin temperature and vigilance during the day and are compatible with the hypothesis of overlap in brain networks involved in the regulation of temperature and vigilance. From an applied point of view, especially proximal skin temperature assessment may be of use in vigilance monitoring.
Synchronized Circadian Bioluminescence in Cave-Dwelling Arachnocampa tasmaniensis (Glowworms)
Authors: Merritt David J. , Clarke Arthur K.
Published: January 2011

Larvae of the genus Arachnocampa, known as glowworms, are bioluminescent predatory insects that use light to attract prey. One species, Arachnocampa flava, is known to possess true circadian regulation of bioluminescence: light:dark cycles entrain the rhythm of nocturnal glowing. Given the absence of natural light as a cue in caves, we addressed the question of whether cave populations of Arachnocampa tasmaniensis, a species known to inhabit caves as well as epigean environments, are rhythmic. We found that the major dark-zone cave populations of A. tasmaniensis maintain a high-amplitude 24-hour rhythm of bioluminescence, with the acrophase during external daylight hours. Populations of A. tasmaniensis in caves many kilometers apart show similar, but not exactly the same, timing of the acrophase. Systematic investigation of colonies in the dark zone of a single cave showed that some smaller colonies distant to the main ceiling colony, also in the dark zone, glow in antiphase. Periodic monitoring of a single colony over several years showed that the acrophase shifted from nocturnal to diurnal some time between October 2008 and January 2009. Prey availability was investigated as a possible zeitgeber. The acrophase of prey availability, as measured by light trapping, and the acrophase of bioluminescence do not precisely match, occurring 3 hours apart. Using in-cave artificial light exposure, we show that after LD cycles, cave larvae become entrained to bioluminesce during the foregoing photophase. In contrast, epigean larvae exposed to artificial LD cycles after a period of DD become entrained to bioluminesce during the foregoing scotophase. One explanation is that individuals within colonies in the dark zone synchronize their bioluminescence rhythms through detection and matching of each other ’s bioluminescence.
Lunar Rhythms in the Deep Sea: Evidence from the Reproductive Periodicity of Several Marine Invertebrates
Authors: Mercier Annie , Zhao Sun  , Baillon Sandrine , Hamel Jean-François
Published: January 2011

While lunar rhythms are commonly documented in plants and animals living in terrestrial and shallow-water environments, deep-sea organisms have essentially been overlooked in that respect. This report describes evidence of lunar periodicity in the reproduction of 6 deep-sea species belonging to 2 phyla. Occurrences of gamete release in free spawners and larval release in brooders exhibited significant peaks around the new and full moons, respectively. The exact nature of this lunar period (endogenous or exogenous rhythm) and its adaptive significance in the deep sea remain elusive. Current knowledge suggests that proxies of moon phases at depth may include fluxes in particulate matter deposition, cyclic currents, and moonlight for species living in the disphotic zone.
Gender in Context, Content, and Approach
Authors: Denny Kathleen E.
Published: January 2011

I explore gender messages in Boy Scout and Girl Scout handbooks through an analysis of how gender is infused in the context and content of Scout activities as well as in instructions about how the Scouts are to approach these activities. I find that girls are offered more activities intended to be performed in group contexts than are boys. Boys are offered proportionately more activities with scientific content and proportionately fewer artistic activities than are girls. The girls’ handbook conveys messages about approaching activities with autonomous and critical thinking, whereas the boys’ handbook facilitates intellectual passivity through a reliance on organizational scripts. Taken together, girls’ messages promote an “up-to-date traditional woman” consistent with the Girl Scouts’ organizational roots; boys’ messages promote an assertive heteronormative masculinity that is offset by facilitating boys’ intellectual passivity.
Gendering Agricultural Aid
Authors: Ransom Elizabeth , Bain Carmen
Published: January 2011

Gender-based inequalities constrain women’s ability to participate in efforts to enhance agricultural production and reduce poverty and food insecurity. To resolve this, development organizations have targeted women and more recently “mainstreamed” gender within their agricultural aid programs. Through an analysis of agricultural-related development aid, we examine whether funded agricultural projects have increasingly targeted women and/or gender. Our results show that the number of agricultural aid projects and the dollar amounts targeting women/gender increased between 1978 and 2003. However, the increase was modest and, as a percentage of all agricultural development aid, has declined since the late 1990s. Significantly, this decline occurs at a time when there are an increasing number of women engaged in agriculture. Our findings suggest that the rhetoric of gender mainstreaming outstrips efforts to develop projects aimed at women and gender inequality and that the concept may be being used to legitimize a decline in focusing explicitly on women.
Crying That Heals
Authors: Griffith Mary Bess , Hall Joanne M. , Fields Becky
Published: January 2011

Although much has been written about the healing power of tears, the research into this phenomenon has been fragmented, uncoordinated, and inconclusive. Nonetheless, a substantial amount of the literature across multiple disciplines has addressed the subject, both directly and indirectly. In this article, the authors submit crying that heals (CTH) as a concept of possible significance to health care and evaluate CTH using the criteria for concept evaluation proposed by Morse, Mitcham, Hupcey, and Tasón (1996) . Using these criteria, CTH is tentatively defined, and its characteristics, boundaries, preconditions, and outcomes are proposed and examined in the context of this definition. Suggestions for additional analysis and research are offered, and the potential importance of CTH to health care professions, especially nursing, is discussed.
Why primaries? The party’s tradeoff between policy and valence
Authors: Serra Gilles
Published: January 2011

Our theory studies why and when political parties choose to hold competitive primary elections. Party leaders can decide the nomination by granting resources and endorsements to a chosen candidate. Alternatively, they can delegate the candidate selection to the party’s rank and file by holding a primary election among multiple candidates. The benefit of a primary is to increase the expected valence of the nominee. Its cost is the ideology that primary voters might induce on the party’s policy platform. We find that primary elections are more likely to be used when the potential primary voters are not too moderate and not too extremist. We also find that opposition parties and weak parties benefit from primaries more than incumbent parties and strong parties do. Intriguingly, extremist parties are more likely to adopt primaries than centrist parties are. Contradicting previous research, we find that primaries are more attractive when candidates’ skills are less salient for voters than candidates’ policies.
Are group sources always credible? An experimental study of sources, stakes and participation
Authors: Aroopala Christy
Published: January 2011

When is mobilization of group identity successful? Work on social movements suggests that frames that target group identity can mobilize groups. However, this work does not address when group mobilization using frames is likely to be successful. Recent work on source credibility finds that same-group sources are an important moderator of framing effects, and previous work on stakes of the decision shows that individuals in high stakes are more likely to participate than those in low stakes. I combine these two moderators of frames to generate predictions for when group sources are most likely to be credible. I test these predictions in the context of a public goods game laboratory experiment in which targeted frames are given to group members by sources that share their group identity and in which stakes of the decision are varied. The findings of this project have implications for political mobilization and campaigning based on group identities.
Optimal counterterrorism and the recruitment effect of large terrorist attacks: A simple dynamic model
Authors: Jensen Thomas
Published: January 2011

We analyze a simple dynamic model of the interaction between terrorists and authorities. Our primary aim is to study optimal counterterrorism and its consequences when large terrorist attacks lead to a temporary increase in terrorist recruitment. First, we show that an increase in counterterrorism makes it more likely that terrorist cells plan small rather than large attacks and therefore may increase the probability of a successful attack. Analyzing optimal counterterrorism we see that the recruitment effect makes authorities increase the level of counterterrorism after large attacks. Therefore, in periods following large attacks a new attack is more likely to be small compared to other periods. Finally, we analyze the long-run consequences of the recruitment effect. We show that it leads to more counterterrorism, more small attacks, and a higher sum of terrorism damage and counterterrorism costs. On the other hand, it leads to fewer large attacks and less damage.
Sex during menstruation: Race, sexual identity, and women’s accounts of pleasure and disgust
Authors: Fahs Breanne
Published: January 2011

While much research has addressed negativity surrounding women’s menstruation, surprisingly little research has interrogated the relationship between menstruation and sexuality. This study used inductive thematic analysis of qualitative interviews with 40 women across a range of age, race and sexual orientation backgrounds to examine women’s experiences with sex during menstruation. Results showed that, while 25 women described negative reactions — and two described neutral reactions — 13 women described positive reactions to menstrual sex. Negative responses cohered around four themes: women’s discomfort and physical labor to clean ‘messes’, overt partner discomfort, negative self-perception and emotional labor to manage partner’s disgust. Positive responses cohered around two themes: physical and emotional pleasure from sex while menstruating, and rebellion against anti-menstrual attitudes. Notable race and sexual identity differences appeared, as white women and bisexual or lesbian-identified women described positive feelings about menstrual sex more than women of color or heterosexual women. Bisexual women with male partners described more positive reactions to menstrual sex than did heterosexual women with male partners, implying that heterosexual identity related to negative menstrual sex attitudes more than heterosexual behavior. Those with positive menstrual sex attitudes also enjoyed masturbation more than others. Implications for sexual identity and racial identity informing body practices, partner choice affecting women’s body affirmation, and women’s resistance against common cultural ideas about women’s bodies as ‘disgusting’ were addressed.