Use of Colchicine in the Reduction of Cardiovascular Atherosclerotic Events
Authors: Cruz Ana Carolina Correia ,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil., Santos Isabelle Pinheiro , Carvalho Monique Almeida , Paschoal Juliana Fontes Beltran , Vasconcelos Camilla Briza Marques de , Araujo Bruna Daniel , Silva Leonardo Tomé da , Paulino Giovanna Vetter , Júnior Ivanir José Cordeiro Moreira , Ribeiro Laura Aparecida Nascimento , Junqueira Lorenna Santos , Guion Silvia de Oliveira , Reis Rafaela Del Grosso , Benedito Rafaela Ribeiro , Trigueiro Thiago Gaban , Fujishima Hiromi M.K , Ficher Gabriel Sewastjanow , Batista Thainara Caproni , Pascoal Amanda Silva , Vasconcelos Maria Clara Marques de , Souza Vitor Hugo de , Victorello Giovana Rocha , Calheiros Júlio Elias , Carvalho Roselene de O. , Regonha Mariana Machado , Delgado Adriana F. Viana , Yamashiro Giovana Casarini , Ferreira Jaqueline de Carvalho , Bitolo Giovana Clausson , Lima Christopher Aquino Pereira , Carriço Hamilton Roberto Moreira de Oliveira , Alvarenga Cristiano Bento , Bezerra Thiago Augusto Rochetti ,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil. & PhD in Biotechnology, USP, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. Potiguar University. Natal, Rio Grande do Norte, Brazil.,   Medical student. Potiguar University. Natal, Rio Grande do Norte, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil,   Medical student, Nove de Julho University. São Bernardo do Campo, São Paulo, Brazil,   Medical student, Nove de Julho University. São Bernardo do Campo, São Paulo, Brazil,   Medical student, Nove de Julho University. São Bernardo do Campo, São Paulo, Brazil,   Medical student, Nove de Julho University. São Bernardo do Campo, São Paulo, Brazil,   Medical student. University of Southern Santa Catarina. Tubarão, Santa Catarina, Brazil.,   Medical Student, UCP, Central University of Paraguay, Ciudad delEste, Paraguay.,   Medical student. University of Ribeirão Preto. Guarujá, São Paulo, Brazil.& PhD in Medical Sciences. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, São Paulo, Brazil.
Published: July 2024

Introduction: Atherosclerosis begins when the injured artery wall creates chemical signals that cause certain types of leukocytes (monocytes and T cells) to adhere to the artery wall. These cells move towards the artery wall. There, they are transformed into foam cells that collect cholesterol and other fatty materials and trigger the growth of smooth muscle cells in the artery wall. Colchicine or colchicine is a highly poisonous alkaloid, originally extracted from the plant Colchicum autumnale. It has been used in the treatment of various diseases, but on an increasingly smaller scale due to its high toxicity. Aim: The aim of this review is to provide a balanced, critical and comprehensive assessment of the evidence currently available regarding the use of colchicine in the context of atherosclerotic heart disease. Material and Methods: The research was carried out by means of an electronic search for scientific articles published on the Scielo (Scientific Electronic Library Online) and Lilacs (Latin American Health Sciences Literature) and Pubmed websites. The health terminologies consulted in the Health Sciences Descriptors (DeCS/BIREME) were used: r use of Colchicine in the reduction of atherosclerotic cardiovascular events. Results and Discussion: Although there was variation between individual studies, meta-analyses also showed that colchicine reduced the risk of myocardial infarction, stroke or cardiovascular death by between 20 and 30%. The applicability of the results may vary according to subsets of patients. For example, the benefits of colchicine may be even greater in patients with diabetes mellitus. However, as most studies excluded patients with heart failure and chronic kidney disease, the effects of colchicine in these populations are still unknown. Final considerations: if the use of colchicine in the treatment of ischemic heart disease is to be fully viable, a great effort must be made to personalize its use in terms of timing, duration of treatment and dose, reassessing the net clinical benefit of this strategy over time, taking into account the underlying severity of CV disease, the patient's comorbidities and the use of concomitant medications.