bluuebunny/crossref_metadata_2025 huggingface dataset:
Deformed Fréchet law for Wigner and sample covariance matrices with tail in crossover regime
Authors: Han Yi
Published: October 2024

Given $$A_n:=\frac{1}{\sqrt{n}}(a_{ij})$$

A
n

:
=

1

n

(

a

ij

)

an $$n\times n$$

n
×
n

symmetric random matrix, with elements above the diagonal given by i.i.d. random variables having mean zero and unit variance. It is known that when $$\lim _{x\rightarrow \infty }x^4\mathbb {P}(|a_{ij}|>x)=0$$

lim

x
→
∞

x
4

P
(
|

a

ij

|
>
x
)

=
0

, then fluctuation of the largest eigenvalue of $$A_n$$

A
n

follows a Tracy–Widom distribution. When the law of $$a_{ij}$$

a

ij

is regularly varying with index $$\alpha \in (0,4)$$

α
∈
(
0
,
4
)

, then the largest eigenvalue has a Fréchet distribution. An intermediate regime is recently uncovered in Diaconu (Ann Probab 51(2):774–804, 2023): when $$\lim _{x\rightarrow \infty }x^4\mathbb {P}(|a_{ij}|>x)=c\in (0,\infty )$$

lim

x
→
∞

x
4

P
(
|

a

ij

|
>
x
)

=
c
∈

(
0
,
∞
)

, then the law of the largest eigenvalue converges to a deformed Fréchet distribution. In this work we vastly extend the scope where the latter distribution may arise. We show that the same deformed Fréchet distribution arises (1) for sparse Wigner matrices with an average of $$n^{\Omega }(1)$$

n
Ω

(
1
)

nonzero entries on each row; (2) for periodically banded Wigner matrices with bandwidth $$p_n=n^{O(1)}$$

p
n

=

n

O
(
1
)

; and more generally for weighted adjacency matrices of any $$k_n$$

k
n

-regular graphs with $$k_n=n^{\Omega (1)}$$

k
n

=

n

Ω
(
1
)

. In all these cases, we further prove that the joint distribution of the finitely many largest eigenvalues of $$A_n$$

A
n

converge to a deformed Poisson process, and that eigenvectors of the outlying eigenvalues of $$A_n$$

A
n

are localized, implying a mobility edge phenomenon at the spectral edge 2 for Wigner matrices. The sparser case with average degree $$n^{o(1)}$$

n

o
(
1
)

is also explored. Our technique extends to sample covariance matrices, proving for the first time that its largest eigenvalue still follows a deformed Fréchet distribution, assuming the matrix entries satisfy $$\lim _{x\rightarrow \infty }x^4\mathbb {P}(|a_{ij}|>x)=c\in (0,\infty )$$

lim

x
→
∞

x
4

P
(
|

a

ij

|
>
x
)

=
c
∈

(
0
,
∞
)

. The proof utilizes a universality result recently established by Brailovskaya and Van Handel (Universality and sharp matrix concentration inequalities, 2022).
Does Embodiment in Virtual Reality Boost Learning Transfer? Testing an Immersion-Interactivity Framework
Authors: Klingenberg Sara , Bosse Robin , Mayer Richard E. , Makransky Guido
Published: October 2024

This study investigates the role of embodiment when learning a technical procedure in immersive virtual reality (VR) by introducing a framework based on immersion and interactivity. The goal is to determine how increasing the levels of immersion and interactivity affect learning experiences and outcomes. In a 2 × 2 factorial design, 177 high school students were assigned to one of four experimental conditions, varying levels of immersion (learning in immersive virtual reality wearing a head-mounted display (VR) vs. learning via a computer screen (PC)) and interactivity (directly manipulating objects using controllers/mouse and keyboard (congruent) vs. indirectly manipulating objects with a laser pointer to select a course of action (incidental)). The main outcome measure was a transfer task in which students were required to perform the task they had learned in the virtual environment using concrete objects in real life. Results demonstrated that students in the VR conditions experienced significantly higher levels of presence, agency, location, body ownership, and embodied learning compared to participants in the PC conditions. Additionally, students’ performance during the virtual lesson predicted their real-life transfer test. However, there were no significant effects of immersion or interactivity on any of the transfer measures. The results suggest that high immersion in VR can increase self-reported measures of presence, agency, location, body ownership, and embodied learning among students. However, increased embodiment—manipulated by adding immersion and congruent manipulation of objects did not improve transfer.
Freedom in the Many-Worlds Interpretation
Authors: Stoica Ovidiu Cristinel
Published: October 2024

I analyze the possibility of free-will in the many-worlds interpretation (MWI), arguing for their compatibility. I use as a starting point Nicolas Gisin’s “The Multiverse Pandemic” (preprint arXiv:2210.05377, 2022, after Gisin, N., “L’épidémie du multivers”, in “Le Plus Grand des Hasards”, Belin, Paris, 2010), in which he makes an interesting case that MWI is contradicted by our hard to deny free-will. The counts he raised are: (1) MWI is deterministic, forcing choices on us, (2) in MWI all our possible choices happen, and (3) MWI limits creativity, because everything is entangled with everything else. I argue that each of these features of MWI is in fact compatible with more freedom than it may seem. In particular, MWI allows compatibilist free-will, but also free-will very much like the libertarian free-will defined by Chisholm. I argue that the position that alternative choices exist as possibilities does not make sense from a physical point of view, but MWI offers a physical ground for alternatives.
Woody flowering plants support early-spring pollinators in urban greenspaces
Authors: Wierzchowski Tori M. , Haden Brooke L. , Ren Abigail T. , Hung Keng-Lou James
Published: October 2024

One threat pollinators face in a rapidly changing climate is the decoupling of their activity period from the blooming period of their host plants. Pollinators active in the earliest part of spring may be especially susceptible, as there are few alternative food resources available if they become active before their host plants begin blooming. Thus, urban landscapes, although often associated with decreased insect biodiversity, may buffer pollinators from such food shortages by offering a diversity of both native and exotic plant species that bloom in the late winter and early spring. However, more data are needed to ascertain the degree to which pollinators utilize flowers of spring-blooming exotic species. Here, we surveyed flower-visiting Hymenoptera and Diptera on 26 flowering plant taxa in three urban botanical gardens in the Oklahoma City metropolitan area in the early spring (March and April). We found that flowers of both native and exotic plants were attractive to Hymenoptera and Diptera, although pollinator visitation rates varied by more than an order of magnitude across plant taxa. Overall, woody plants were more attractive to pollinators compared to herbaceous plants, regardless of whether the plant was native or exotic. Implications for insect conservation: Our results suggest that regardless of native status, urban plants that bloom in the early spring—especially woody species—may be coopted to support pollinators that are especially susceptible to climate change. However, care needs to be taken to select plant species and varieties that pollinators will actually use.
Motivations for Direct-to-Consumer Genetic Testing: Understanding Interpretations of Ancestry Results
Authors: Friedman Asia , Anderson Tammy L.
Published: October 2024

Direct-to-consumer genetic testing (DTCGT) has the potential to significantly impact racial and ethnic identities as well as social concepts of race and ethnicity. Prior literature challenges the binary choice of essentialism vs. constructionism in understanding consumers’ interpretations of genetic ancestry results. Largely focusing on differences by race and ethnicity, this research finds that test takers selectively apply genetically determinist logic depending on their prior identities and interests. We extend this line of inquiry using in-depth interviews with thirty-six mostly white participants who had previously taken a DTCGT offering combined health and ancestry results, which provided an opportunity to explore how different motivations for testing – e.g., for health or ancestry information – impact interpretations of ancestry results. Our analysis reveals distinct patterns in how health- vs. ancestry-motivated consumers invoke genetic determinism in their interpretations of DTCGT results. At the same time, regardless of motivation for testing, we found little use of genetic results to challenge the coherence or biological basis of racial or ethnic categories. Our results suggest that even if genetic determinism is only selectively applied, and in ways that vary between consumers with different motivations for testing, at least among whites, discourses of genetics as “truth” and white normativity are nonetheless the prevailing interpretive frameworks for genetic ancestry results.
Parameter estimation for second-order SPDEs in multiple space dimensions
Authors: Bossert Patrick
Published: October 2024

We analyse a second-order SPDE model in multiple space dimensions and develop estimators for the parameters of this model based on discrete observations of a solution in time and space on a bounded domain. While parameter estimation for one and two spatial dimensions was established in recent literature, this is the first work which generalizes the theory to a general, multi-dimensional framework. Our approach builds upon realized volatilities, enabling the construction of an oracle estimator for volatility within the underlying model. Furthermore, we show that the realized volatilities have an asymptotic illustration as response of a log-linear model with spatial explanatory variable. This yields novel and efficient estimators based on realized volatilities with optimal rates of convergence and minimal variances. For proving central limit theorems, we use a high-frequency observation scheme. To showcase our results, we conduct a Monte Carlo simulation.
Investing in people, not in products: how age, gender, ethnicity, and attractiveness of entrepreneurial teams influence the decision-making of angel investors in Germany
Authors: Boerner Livia , Fritz Thomas , Frick Bernd
Published: October 2024

The high-risk decision environment and information asymmetries associated with investing in early-stage startups in pitch competitions make angel investors prone to biased decision-making. Drawing from social perception theory, this study examines how angel investors’ decisions are influenced by observed personal characteristics of entrepreneurial teams, based on representative stereotypes. Analyzing a dataset of N = 553 startup pitches from the German televised competition Die Höhle der Löwen, this study reveals that the likelihood of securing deals with German angel investors and the resulting business valuations are linked to certain superficial team characteristics. Specifically, the age, diverse ethnicity, and physical attractiveness of the entrepreneurial team have a significant positive effect on deal probabilities. Moreover, angel investors offer lower deal valuations to teams of older and female entrepreneurs, suggesting the presence of a systematic bias. These insights contribute to understanding the role of stereotypes in entrepreneurial finance and address the challenges related to bias in access to capital for early-stage startups in Germany.
Customer insights for innovation: A framework and research agenda for marketing
Authors: Stremersch Stefan , Cabooter Elke , Guitart Ivan A. , Camacho Nuno
Published: October 2024

Customer insights play a critical role in innovation. In recent years, articles studying customer insights for innovation have risen in marketing and other fields such as innovation, strategy, and entrepreneurship. However, the literature on customer insights for innovation grew fragmented and plagued by inconsistent definitions and ambiguity. The literature also lacks a precise classification of different domains of customer insights for innovation. This article offers four key contributions. First, it clearly and consistently defines customer insights for innovation. Second, it proposes a “customer insights process” that describes the activities firms and customer insights intermediaries (e.g., market research agencies) use to generate, disseminate, and apply customer insights for innovation. Third, it offers a synthesis of the knowledge on customer insights for innovation along ten domains of customer insights for innovation: (1) crowdsourcing, (2) co-creating, (3) imagining, (4) observing, (5) testing, (6) intruding, (7) interpreting, (8) organizing, (9) deciding, and (10) tracking. Fourth, the authors qualify and quantify the managerial importance and potential for scholarly research in these domains of customer insights for innovation. They conducted 12 in-depth interviews with executives at market research agencies such as Ipsos, Kantar, Nielsen, IQVIA, and GfK to do so. They surveyed 305 managers working in innovation, marketing, strategy, and customer experience. The article concludes with a research agenda for marketing aimed at igniting knowledge development in high-priority domains for customer insights for innovation.
Modeling inter-organizational business process governance in the age of collaborative networks
Authors: Ribeiro Vítor , Barata João , da Cunha Paulo Rupino
Published: October 2024

Collaborative networks require inter-organizational business process governance (IO-BPG) mechanisms to define ownership over shared resources and activities, accountability over operations, inter-organizational roles and responsibilities, and strategic partner alignment. We developed an IO-BPG modeling approach aiming to incorporate (1) IT governance activities (e.g., IT performance measurement), (2) data governance activities (e.g., data strategy management), and (3) “shadow” parallel governance-related operations. Resulting from a design science research project, our contributions include the building blocks (domain attributes, ontology, and requirements) of a novel BPMN extension, its demonstration in logistics operations, its evaluation, and design principles to guide IO-BPG modeling. Suggestions for the development and evaluation of future BPMN extensions are also highlighted based on the lessons learned in this project. For practitioners, our contribution can improve accountability reports over data assets and operations, identify dataset ownership, assist in the coordination of governance activities in networked businesses, and comply with regulations and strategic partnership agreements.
Adaptive backstepping and sliding mode control of a quadrotor
Authors: Maaruf Muhammad , Abubakar Abdulrazaq Nafiu , Gulzar Muhammad Majid
Published: October 2024

This article proposes a simple robust adaptive control architecture with minimum parameter estimation laws for trajectory tracking of a quadrotor subjected to parametric variations and environmental disturbances. This simple control architecture aims to achieve highly accurate, robust, and fast trajectory tracking of the quadrotor in a short time with low computational cost. Firstly, the quadrotor model is divided into altitude, attitude, and position subsystems for which appropriate control methods are designed without prior knowledge of the upper bound of external disturbances. A simple adaptive fractional-order sliding mode control (AFSMC) is designed to enhance the tracking of the altitude subsystem and estimate the upper bound of the disturbances. Then, a simple adaptive backstepping control (ABC) is developed for the horizontal position to generate the required roll and pitch orientations. The adaptation laws not only estimate the upper bound of the disturbances but also adjust the controller gains thereby enhancing the robustness of the ABC. A nonsingular fast terminal sliding mode control (NFTSMC) is incorporated with a finite-time disturbance observer (FDO) to accurately suppress the disturbances, and follow the target rotation angles within a short finite-time. Simulation results showed that the compounded control structure ensures accurate, fast, and robust tracking. The AFSMC can achieve the desired altitude with a settling time of 0.31 s and root mean square error (RMSE) of 0.0454 m. The ABC can attain the target horizontal position coordinates with a settling time of (0.47 s, 0.47 s) and RMSE of (0.0370 m, 0.0518 s). The NFTSMC-FDO can achieve the desired attitude angles with a settling time of (0.11 s, 0.13 s, 0.52 s) and RMSE of (0.0098 rad, 0.0092 rad, 0.0935 rad). Performance comparisons with existing control methods in terms of settling time and RMSE demonstrated that the proposed control architecture is superior.
Embracing a different outlook: Strengths and goals of individuals currently in treatment for anorexia nervosa
Authors: Dann Kelly M. , Harrison Amy , Veldre Aaron , Hay Phillipa , Touyz Stephen
Published: October 2024

Purpose

Developing personal goals beyond weight and shape, and promoting the agency to pursue those goals, could aid in treatment and recovery from anorexia nervosa (AN). This research explores the strengths, interests and goals of individuals currently receiving treatment for AN and evaluates how treatment services are supporting them to work towards personal goals across all areas of everyday life.

Method

A total of 58 community-dwelling adults currently receiving treatment for anorexia nervosa at any stage of recovery completed the Client Assessment of Strengths, Interests and Goals Self-Report (CASIG-SR). Participants reported their goals for accommodation, work and study, interpersonal relationships, recreational activities, spirituality, religion or life purpose, physical health and mental health, and the personal strengths and supports needed to achieve those goals. Concordance scores were calculated between importance of personal goals and level of support from current services regarding these goals.

Results

Themes identified across goals, strengths and supports were Connection, Independence & Confidence, Meaning & Self: The Real Me, and Stability & Balance. Work and study goals and strengths were identified strongly. The key support needed was stability from the current treatment team to provide a stable base for change. Concordance scores indicate support provided for personal goals was less than the importance of the goal to the individual.

Conclusion

Results suggest goals for everyday living are critical to recovery in anorexia nervosa. Specific clinical considerations to increase motivation and hope are increased access to peer support, a focus on increasing positive affect, supporting safe exercise and promoting outdoor experiences and connection with nature.

Level III

Evidence obtained from well-designed cohort or case–control analytic studies.
Valid and invalid causal arguments for physicalism
Authors: Kroedel Thomas
Published: October 2024

In “A Causal Argument for Physicalism”, Lei Zhong presents an argument for physicalism in general, that is, for the disjunction of reductive physicalism and non-reductive physicalism. Zhong’s argument attempts to show that mental properties are physically acceptable, that is, physical in a wide sense. The crucial assumption of the argument is that physically acceptable effects do not have both sufficient causes that are physically acceptable and simultaneous sufficient causes that are not physically acceptable. I argue that Zhong’s argument is invalid, because the mental can be causally relevant to physically acceptable effects while being neither physically acceptable nor causally sufficient for these effects. I present an alternative argument in the spirit of Zhong’s argument that omits the notion of sufficient causation. I argue that non-physicalists can also resist the alternative argument if they fine-tune their metaphysics of mind.
The Imported Challenge: Economic Impact of Fresh Fruit and Vegetable Imports on U.S. Producers
Authors: Khanal Ajit , Poudel Dixit , Gopinath Munisamy
Published: October 2024

Domestic fruit and vegetable producers contend that rising imports during seasonal harvesting windows have negatively impacted domestic prices and revenue. This study simulates producers’ revenue with the removal of above-average imports as defined by the U.S. International Trade Commission. Results indicate significant additional revenues to domestic producers in the simulated scenario. Also, additional revenues to producers by state and season show substantial heterogeneity with robustness checks revealing similar patterns. Options such as risk management and technological improvements are needed to enhance the competitiveness of U.S. fresh produce industries instead of limiting imports in the absence of illegal dumping.
Exploring museums and libraries as new sites for Cognitive Stimulation Therapy
Authors: Gourlay Catriona
Published: October 2024

What role can museums and libraries play in improving people's health and wellbeing? This is the question staff at the V&A Museum are exploring through Cognitive Stimulation Therapy (CST), a treatment designed for adults with a recent diagnosis of dementia, traditionally delivered in a clinical setting. Guided by experts from the dementia charity Resonate Arts and the NHS's Memory Service, V&A curators and librarians are discovering the great potential of the museum and its collections to improve and enrich lives.
Viewpoint: How critical can librarians be?
Authors: Brett Rachel
Published: October 2024

Critical librarianship has become embedded into the epistemological structure of the LIS profession. Those working in art libraries and the Art Libraries Journal have played no small role in this, fostering progressive discussions around issues of social injustice that orbit the library and its functions. Nevertheless, the kernel of critical theory that developed out of the Frankfurt School centred upon class and economics. Librarianship, especially art librarianship, continues to be a middle-class career requiring an expensive higher qualification to enter. This requirement indicates the contradictions operating within and around the sector. As the commodification of education continues to creep in, class and economics are urgent topics that demand to be addressed by the critical librarianship movement. Yet those who practice critical librarianship remain employees of this very system and as such, the question posed is, what, if anything, can librarians do about their role within the education system to disrupt the commodification of education? The proposal is offered that librarians and artworks have more in common than seems possible. This idea is explained by briefly introducing artwork as a monad, concluding that art and perhaps librarians reflect the society that created them but cannot change it. Nevertheless, the very existence of art reflects the possibilities of such change, and maybe this is its role.
Twenty-Fifth Annual Grotius Lecture
Authors: Scheppele Kim Lane , Cepeda Espinosa Manuel José
Published: October 2024

In what now seems like a different world, Thomas Franck published an article in the American Journal of International Law defending an “emerging right to democratic governance.”1 The year was 1992. The post-Soviet revolutions had startled the world, following equally stunning democratization drives in Latin America and Southern Europe. Democracy seemed the inevitable endpoint of human civilization, the “end of history”2 as it was called then. If all newly freed peoples demanded democracy as soon as they had a chance to choose their form of government, an emerging right to democratic governance could both reinforce their choices and pull along the laggards with the moral force of international law.3
Capacity of a set of CMIP6 models to simulate Arctic sea ice drift
Authors: Zhang Xinfang , Haapala Jari , Uotila Petteri
Published: October 2024

Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014. We compare the output from selected CMIP6 models with reference data for sea ice motion. We also discuss the correlations between sea ice motion(SIM) and sea ice thickness (SIT) in reference data, and how CMIP6 models explain them. We select EC-Earth3, ACCESS-CM2, BCC-CSM2-MR, MPI-ESM1-2-HR, and NorESM2-LM for CMIP6 study. We compare outputs with reference data: Sea ice extent (SIE) from NSIDC; SIT from PIOMAS; and SIM from the IABP buoy data. Analytical techniques include Theil-Sen and Ordinary least squares (OLS) regression. Most selected CMIP6 models have seasonal cycles of SIM lagging behind IABP observations by 1-2 month and overestimate central Arctic SIM magnitude, with MPI-ESM1-2-HR having the highest discrepancy and NorESM2-LM lowest. The models show better simulation of SIM in the ice melting season than in the growing season. Models perform worse at capturing regional differences in SIM evolution and are overly conservative when simulating the increasing trend in ice motion, especially in coastal Arctic seas during summer. There is significant negative correlation between SIT and SIM in October.
Eastern Australian estuaries will transition to tidal flood regimes in coming decades
Authors: Hague Ben S. , Thran Mandi C. , Jakob Doerte , Jones David A.
Published: October 2024

Tidal flooding occurs when coastal water levels exceed impact-based flood thresholds due to tides alone, under average weather conditions. Transitions to tidal flood regimes are already underway for nuisance flood severities in harbours and bays and expected for higher severities in coming decades. In the first such regional assessment, we show that the same transition to tidally forced floods can also be expected to occur in Australian estuaries with less than 0.1 m further sea-level rise. Flood thresholds that historically used to only be exceeded under the combined effects of riverine (freshwater) and coastal (salt water) influences will then occur due to high tides alone. Once this tidal flooding emerges, it is projected to become chronic within two decades. Locations most at-risk of the emergence of tidal flooding and subsequent establishment of chronic flood regimes are those just inside estuary entrances. These locations are exemplified by low freeboard, the vertical distance between a flood threshold and a typical high tide level. We use a freeboard-based analysis to estimate the sea-level rise required for impacts associated with official flood thresholds to occur due to tides alone. The resultant tide-only flood frequency estimates provide a lower bound for future flood rates.
NADPH-cytochrome P450 reductase involved in the lambda-cyhalothrin susceptibility on the green mirid bug Apolygus lucorum
Authors: Zhen Congai , Wu Rui , Tan Yao , Zhang Ansheng , Zhang Lei
Published: October 2024

NADPH-cytochrome P450 reductase (CPR) is crucial for the detoxification process catalysed by cytochrome P450, which targets various exogenous xenobiotics, as well as pesticides. In our research, we successfully obtained the complete cDNA sequence of Apolygus lucorum's CPR (AlCPR) using reverse transcription PCR along with rapid amplification of cDNA ends technology. Bioinformatics analysis exhibited that the inferred amino acid sequence of AlCPR is characteristic of standard CPRs, featuring an N-terminal membrane anchor and three conserved FMN, FAD and NADP binding sites. Phylogenetic result revealed that AlCPR was positioned within the Hemiptera cluster, showing a close evolutionary relationship with the CPR of Cimex lectularius. The real-time quantitative PCR results demonstrated widespread expression of AlCPR across various life stages and tissues of A. lucorum, with the most prominent expression in adults and the abdominal region. Injecting double-stranded RNA of AlCPR only significantly increased the lambda-cyhalothrin susceptibility in lambda-cyhalothrin-resistant strain rather than the susceptible strain. These findings suggest a potential link between AlCPR and the P450-dependent defence mechanism against lambda-cyhalothrin in A. lucorum.
Exodus and return: State-building, local responses, and identity negotiation in China's Burma borderlands, 1949–66
Authors: Lei Lihong
Published: October 2024

This article, grounded in archival research from Chinese border prefectures, delves into the complexities of migration dynamics, specifically the phenomena of exodus from and return to China following the Communist takeover in 1949. It reveals how various reforms, enforced collectivisation and religious restrictions disrupted local lives, causing social panic and identity crises, which led to the disintegration of everyday life among borderland communities. Local residents’ responses predominantly involved crossing the border to seek refuge in Burma. The article critically scrutinises local authorities’ efforts to alleviate resultant instability, with the aim of retaining the borderland populace and attracting back those who had left, while also imposing the ideologies of the new communist state. Rather than viewing these ‘illicit’ cross-border movements as mere acts of resistance to governance, this study argues that they involved active negotiations for a stable daily life amid socio-political upheaval. The research contributes new insights into the micro-level mechanisms of state-building, and the integration of borderland peoples into the new Communist regime. Amid mass emigration and repatriation, state engagement permeated daily life in borderland communities, facilitating national identity formation and nation-state construction.
How do adolescents consider life and death? A cognition-to-action framework for suicide prevention
Authors: Benzekri Adam , Morris-Perez Pamela
Published: October 2024

Rising rates of suicide fatality, attempts, and ideations among adolescents aged 10–19 over the past two decades represent a national public health priority. Theories that seek to understand suicidal ideation overwhelmingly focus on the transition from ideation to attempt and on a sole cognition: active suicidal ideation – the serious consideration of killing one’s self, with less attention to non-suicidal cognitions that emerge during adolescence that may have implications for suicidal behavior. A large body of research exists that characterizes adolescence not only as a period of heightened onset and prevalence of active suicidal ideation and the desire to no longer be alive (i.e., passive suicidal ideation), but also for non-suicidal cognitions about life and death. Our review synthesizes extant literature in the content, timing and mental imagery of thoughts adolescents have about their (1) life; and (2) mortality that may co-occur with active and passive suicidal ideation that have received limited attention in adolescent suicidology. Our “cognition-to-action framework for adolescent suicide prevention” builds on existing ideation-to-action theories to identify life and non-suicidal mortality cognitions during adolescence that represent potential leverage points for the prevention of attempted suicide and premature death during this period and across the life span.
Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression
Authors: Lindley Baron-Cohen K. , Fearon P. , Meins E. , Feldman R. , Hardiman P. , Rosan C. , Fonagy P.
Published: October 2024

Previous studies show that maternal mind-mindedness positively impacts children’s social development. In the current studies, we examine the relation between mind-mindedness during parent–child interaction, oxytocin (OT), and postnatal depression in a sample of mothers (N = 62, ages 23–44) and their infant (ages 3–9 months). In Study 1, infant salivary OT was positively correlated with mothers’ appropriate mind-related comments, and negatively correlated (at trend level) with maternal depression scores. Mothers experiencing symptoms of depression used fewer appropriate mind-related comments than controls. Study 2 was a double-blind, placebo-controlled, experimental study, in which the same women who participated in Study 1 were administered nasal OT. This did not significantly influence levels of mind-mindedness. Study 2 warrants a larger trial to investigate the effect of OT on mind-mindedness further. Study 1 is the first to demonstrate an association between maternal mind-mindedness and variation in children’s OT levels. Since both OT and mind-mindedness have been repeatedly implicated in processes of maternal–infant attachment, this association highlights the centrality of mothers’ caregiving representations in facilitating the parent–child relationship and children’s early development.
Institutional Dimension of Burnout in Governmental Psychosocial and Community Programmes: Gaps between Intervening Conditions, Consequences, and Guidelines for Improvement
Authors: Daher Marianne , Rosati Antonia , Tomicic Alemka , Hernández Angie , Alfaro Jaime
Published: October 2024

This article analyses burnout in governmental psychosocial and community programmes considering training/knowledge, the technical-professional field, the institutional framework, and networking, based on the experience of the intervention teams of three Chilean programmes. A qualitative methodology was used. Fifty people, most of them psychologists, participated in interviews and focus groups. The data were analysed according to Grounded Theory. Results indicate that burnout is a corrosive process in governmental psychosocial and community programmes. The causes of burnout are related to three gaps: between academic training and professional performance, between formulation and implementation, and between the obligation to work as part of a network and the limitations of this approach. Furthermore, we observed manifestations consequences and effects of burnout, and guidelines for improving the programmes. We discuss the institutional dimension of burnout in governmental psychosocial and community programmes and reflect on aspects that may improve team well-being and the quality of social policies.
An integrated approach to delaying herbicide resistance in Palmer amaranth (Amaranthus palmeri) by quantifying selection for resistance in a 2,4-D-based cotton production system
Authors: Randell-Singleton Taylor , Hand Lavesta C. , Vance Jenna C. , Culpepper A. Stanley
Published: October 2024

Integrated weed management practices that reduce selection for resistance on herbicides are critical to delay resistance. To quantify the reduction in selection for resistance placed on Palmer amaranth from 2,4-D applied postemergence in cotton, an experiment was conducted three times in Georgia during 2020 and 2021 evaluating the benefits of (i) a cover crop, (ii) preemergence herbicides, and (iii) timeliness of applications. When a timely total-postemergence program of glyphosate + 2,4-D was applied three times over the season in a conventionally tilled system, 281,690 glyphosate-resistant Palmer amaranth plants ha–1 were exposed to 2,4-D. Over 61,500 of these plants were exposed to multiple 2,4-D applications. Altering the production system to conservation tillage, and including a rolled-rye cover crop, reduced the total number of plants exposed to 2,4-D for the season by 72% and the number of plants exposed multiple times by 60%. Even more effective, including a mixture of residual preemergence herbicides reduced the number of plants exposed to 2,4-D at least once over 99.9%, and reduced multiple exposures over 99.3% for the season; this benefit was observed for both conventional and conservation tillage systems. Delaying the initial application of the total-postemergence program did not influence the number of Palmer amaranth plants treated at least once but increased the number of plants treated multiple times by a factor of 3.7 times. As a result of early-season weed competition, cotton height and yield reductions were also associated with both lack of preemergence residuals and delayed postemergence applications. When considering the goal of minimizing the number of Palmer amaranth treated with a postemergence application of 2,4-D in a cotton system, the preemergence was the most effective option followed by (fb) the cover crop fb making timely postemergence applications. However, the most effective approach was to utilize each of these tactics in the same growing season.
Study of the Weddell Sea Anomaly Using Novel Satellite Altimeter TEC Maps
Authors: Azpilicueta F. , Nava B.
Published: October 2024

The Weddell Sea Anomaly (WSA) is a phenomenon of unique intensity and geographic extent that occurs in December (Southern Hemisphere summer) over the southeastern Pacific and southwestern Atlantic oceans regions. Historically, the classic definition of the WSA refers to a situation in which the midnight NmF2 (or TEC) values are greater than the noon NmF2 (or TEC) values. However, several articles published in the last decades have shown that the WSA is a much more complex phenomenon, and its definition might need to be reformulated. This paper presents a phenomenological description of the WSA using a novel type of vertical Total Electron Content (TEC) maps, obtained from altimeter satellite TEC data. The focus of this study is on the possible connection between the WSA and the unexpected expansion and contraction periods observed on the Equatorial Ionospheric Anomaly (EIA) throughout the Southern Hemisphere. The data analysis revealed that the WSA is only one of a number of observed anomalies. Furthermore, we show a significant correlation between the behavior of the EIA and the Y component of the geomagnetic field, which maximizes in the WSA region. We then present a possible hypothesis for interpreting these results.
Proteomic biomarkers of long-term lung function decline in textile workers: a 35-year longitudinal study
Authors: Zhao Mengsheng , Wei Liangmin , Zhang Longyao , Hang Jingqing , Zhang Fengying , Su Li , Wang Hantao , Zhang Ruyang , Chen Feng , Christiani David C. , Wei Yongyue
Published: October 2024

Background

Occupational exposures contribute significantly to obstructive lung disease among textile workers. However, biomarkers associated with such declines are not available.

Objectives

We conducted a large-scale proteomic study to explore protein biomarkers potentially associated with long-term lung function decline.

Methods

Shanghai Textile Workers Cohort was established in 1981 with 35 years of follow-up, assessing textile workers’ lung functions every five years. Quantitative serum proteomics was performed on all 453 workers at 2016 survey. We employed four distinct models to examine the association between forced expiratory volume in one second (FEV1) and proteins, and consolidated the findings using an aggregated Cauchy association test. Furthermore, proteomic data of UK Biobank (UKB) was used to explore the associations of potential protein markers and decline of FEV1, and the interactions of these proteins were examined through STRING database. Associations were also externally validated using two-sample Mendelian randomizations (MR).

Results

15 of 907 analyzed proteins displayed potential associations with long-term FEV1 decline, including two hemoglobin subunits: hemoglobin subunit beta (HBB, FDR-qACAT = 0.040), alpha globin chain (HBA2, FDR-qACAT = 0.045), and four immunoglobulin subunits: immunoglobulin kappa variable 3–7 (IGKV3-7, FDR-qACAT = 0.003), immunoglobulin heavy chain variable region (IgH, FDR-qACAT = 0.011). Five proteins were significantly associated with the rate of decline of FEV1 in UKB, in which RAB6A, LRRN1, and BSG were also found to be associated with proteins identified in Shanghai Textile Workers Cohort using STRING database. MR indicated bidirectional associations between HBB and FEV1 (P < 0.05), while different immunoglobulin subunits exhibited varying associations with FEV1.

Impact statement

We performed a large-scale proteomic study of the longest-follow-up pulmonary function cohort of textile workers to date. We discovered multiple novel proteins associated with long-term decline of FEV1 that have potential for identifying new biomarkers associated with long-term lung function decline among occupational populations, and may identify individuals at risk, as well as potential pharmaceutical targets for early intervention.
Minimal exposure durations reveal visual processing priorities for different stimulus attributes
Authors: Lanfranco Renzo C. , Canales-Johnson Andrés , Rabagliati Hugh , Cleeremans Axel , Carmel David
Published: October 2024

Human vision can detect a single photon, but the minimal exposure required to extract meaning from stimulation remains unknown. This requirement cannot be characterised by stimulus energy, because the system is differentially sensitive to attributes defined by configuration rather than physical amplitude. Determining minimal exposure durations required for processing various stimulus attributes can thus reveal the system’s priorities. Using a tachistoscope enabling arbitrarily brief displays, we establish minimal durations for processing human faces, a stimulus category whose perception is associated with several well-characterised behavioural and neural markers. Neural and psychophysical measures show a sequence of distinct minimal exposures for stimulation detection, object-level detection, face-specific processing, and emotion-specific processing. Resolving ongoing debates, face orientation affects minimal exposure but emotional expression does not. Awareness emerges with detection, showing no evidence of subliminal perception. These findings inform theories of visual processing and awareness, elucidating the information to which the visual system is attuned.
Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration
Authors: Ng Benjamin , Huang Kevin Y. , Pua Chee Jian , Viswanathan Sivakumar , Lim Wei-Wen , Kuthubudeen Fathima F. , Liu Yu-Ning , Hii An An , George Benjamin L. , Widjaja Anissa A. , Petretto Enrico , Cook Stuart A.
Published: October 2024

In lung disease, persistence of KRT8-expressing aberrant basaloid cells in the alveolar epithelium is associated with impaired tissue regeneration and pathological tissue remodeling. We analyzed single cell RNA sequencing datasets of human interstitial lung disease and found the profibrotic Interleukin-11 (IL11) cytokine to be highly and specifically expressed in aberrant KRT8+ basaloid cells. IL11 is similarly expressed by KRT8+ alveolar epithelial cells lining fibrotic lesions in a mouse model of interstitial lung disease. Stimulation of alveolar epithelial cells with IL11 causes epithelial-to-mesenchymal transition and promotes a KRT8-high state, which stalls the beneficial differentiation of alveolar type 2 (AT2)-to-AT1 cells. Inhibition of IL11-signaling in AT2 cells in vivo prevents the accumulation of KRT8+ cells, enhances AT1 cell differentiation and blocks fibrogenesis, which is replicated by anti-IL11 therapy. These data show that IL11 inhibits reparative AT2-to-AT1 differentiation in the damaged lung to limit endogenous alveolar regeneration, resulting in fibrotic lung disease.
Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure
Authors: Michael Andrew R. M. , Amaral Bruno C. , Ball Kallie L. , Eiriksson Kristen H. , Schriemer David C.
Published: October 2024

Crosslinking mass spectrometry (XL-MS) has the potential to map the interactome of the cell with high resolution and depth of coverage. However, current in vivo XL-MS methods are hampered by crosslinkers that demonstrate low cell permeability and require long reaction times. Consequently, interactome sampling is not high and long incubation times can distort the cell, bringing into question the validity any protein interactions identified by the method. We address these issues with a fast formaldehyde-based fixation method applied prior to the introduction of secondary crosslinkers. Using human A549 cells and a range of reagents, we show that 4% formaldehyde fixation with membrane permeabilization preserves cellular ultrastructure and simultaneously improves reaction conditions for in situ XL-MS. Protein labeling yields can be increased even for nominally membrane-permeable reagents, and surprisingly, high-concentration formaldehyde does not compete with conventional amine-reactive crosslinking reagents. Prefixation with permeabilization uncouples cellular dynamics from crosslinker dynamics, enhancing control over crosslinking yield and permitting the use of any chemical crosslinker.
Grain boundary engineering for efficient and durable electrocatalysis
Authors: Geng Xin , Vega-Paredes Miquel , Wang Zhenyu , Ophus Colin , Lu Pengfei , Ma Yan , Zhang Siyuan , Scheu Christina , Liebscher Christian H. , Gault Baptiste
Published: October 2024

Grain boundaries in noble metal catalysts have been identified as critical sites for enhancing catalytic activity in electrochemical reactions such as the oxygen reduction reaction. However, conventional methods to modify grain boundary density often alter particle size, shape, and morphology, obscuring the specific role of grain boundaries in catalytic performance. This study addresses these challenges by employing gold nanoparticle assemblies to control grain boundary density through the manipulation of nanoparticle collision frequency during synthesis. We demonstrate a direct correlation between increased grain boundary density and enhanced two-electron oxygen reduction reaction activity, achieving a significant improvement in both specific and mass activity. Additionally, the gold nanoparticle assemblies with high grain boundary density exhibit remarkable electrochemical stability, attributed to boron segregation at the grain boundaries, which prevents structural degradation. This work provides a promising strategy for optimizing the activity, selectivity, and stability of noble metal catalysts through precise grain boundary engineering.
ARF1 compartments direct cargo flow via maturation into recycling endosomes
Authors: Stockhammer Alexander , Adarska Petia , Natalia Vini , Heuhsen Anja , Klemt Antonia , Bregu Gresy , Harel Shelly , Rodilla-Ramirez Carmen , Spalt Carissa , Özsoy Ece , Leupold Paula , Grindel Alica , Fox Eleanor , Mejedo Joy Orezimena , Zehtabian Amin , Ewers Helge , Puchkov Dmytro , Haucke Volker , Bottanelli Francesca
Published: October 2024

Cellular membrane homoeostasis is maintained via a tightly regulated membrane and cargo flow between organelles of the endocytic and secretory pathways. Adaptor protein complexes (APs), which are recruited to membranes by the small GTPase ARF1, facilitate cargo selection and incorporation into trafficking intermediates. According to the classical model, small vesicles would facilitate bi-directional long-range transport between the Golgi, endosomes and plasma membrane. Here we revisit the intracellular organization of the vesicular transport machinery using a combination of CRISPR-Cas9 gene editing, live-cell high temporal (fast confocal) or spatial (stimulated emission depletion) microscopy as well as correlative light and electron microscopy. We characterize tubulo-vesicular ARF1 compartments that harbour clathrin and different APs. Our findings reveal two functionally different classes of ARF1 compartments, each decorated by a different combination of APs. Perinuclear ARF1 compartments facilitate Golgi export of secretory cargo, while peripheral ARF1 compartments are involved in endocytic recycling downstream of early endosomes. Contrary to the classical model of long-range vesicle shuttling, we observe that ARF1 compartments shed ARF1 and mature into recycling endosomes. This maturation process is impaired in the absence of AP-1 and results in trafficking defects. Collectively, these data highlight a crucial role for ARF1 compartments in post-Golgi sorting.