bluuebunny/crossref_metadata_2025 huggingface dataset:
SISTEM INFORMASI RESUME PERJALANAN DINAS DI DINAS ESDM PROVINSI SUMATERA SELATAN BERBASIS WEB
Authors: Marlindawati Marlindawati , Maza Andini Sidqin
Published: October 2022

Abstract: The Department of Energy and Mineral Resources of South Sumatra Province is one of the state-owned companies in the energy and electricity of minerals and coal. One of the efforts to increase its activities and to find out the problems that exist in the field is the official trips that are made by the Department of Energy and Mineral Resources. In a month, it can be done six times business trips. Currently, the management of official travel data is carried out through the Ms. Excell, starting from inputting data, making reports to the results of the recapitulation which are stored in the archive book and then inserted into the filing cabinet. This kind of data management can create problems, such as the difficulty of reviewing official travel data and reports because they have to be viewed one by one in the filing cabinet. This action can take a long time due to the amount of data that is always increasing and there is overlap. In addition, the possibility of data being lost or scattered may occur. These are what make the author wants to build a web-based official travel information system so that the problems that often occur today can be solved.

Keywords: official trip, information system, web

 

Abstrak: Dinas Energi dan Sumber Daya Mineral Provinsi Sumatera Selatan merupakan salah satu perusahaan milik negara yang bergerak dibidang energi dan ketenagalistrikan mineral dan batubara. Salah satu upaya dalam meningkatkan aktivitasnya dan untuk mengetahui permasalahan yang ada pada lapangan, maka Dinas ESDM pun perlu melakukan perjalanan dinas.  Dalam satu bulan bisa dilakukan 6 kali perjalanan dinas. Saat ini pengelolaan data perjalanan dinas dilakukan melalui aplikasi Ms. Excell, mulai dari penginputan data, pembuatan laporan sampai hasil rekapitulasi yang disimpan kedalam buku arsip dan selanjutnya dimasukkan kedalam lemari arsip. Pengelolaan data seperti ini tentu saja menimbulkan permasalahan-permasalahan, diantaranya kesulitan untuk melihat kembali data perjalanan dinas dan laporan-laporan  karena harus dilihat satu-persatu didalam lemari arsip dan ini membutuhkan waktu yang lama karena jumlah data yang selalu bertambah dan juga terjadinya tumpang tindih. Selain itu, kemungkinan data hilang atau tercecer bisa saja terjadi. Hal inilah yang membuat penulis ingin membangun sebuah sistem informasi perjalanan dinas berbasis web, agar permasalahan-permasalahan yang sering terjadi saat ini bisa teratasi.  

Kata kunci: perjalanan dinas, sistem informasi, web
PERANCANGAN SISTEM INFORMASI DATA PERSEDIAAN BARANG PADA TOKO BANGUNAN PADMA JAYA BERBASIS VB.NET
Authors: Banyal Nur Ain , Talumewo Debby Maureen , Surianti Surianti
Published: October 2022

Abstrak : Teknologi dan  Informasi merupakan  dua hal yang tidak dapat dipisahkan  satu  sama  lainnya dan peran teknologi sangat dibutuhkan disemua bidang dan salah satunya adalah pada Toko Padma Jaya dimana Toko ini sering mengalami masalah dalam pengolahan barang masuk dan barang keluar berserta stok yang ada pada gudang sering terjadi kekeliruan data barang. Dengan tujuan dapat merancang sistem informasi data persediaan barang pada toko bangunan Padma Jaya berbasis VB.NET untuk mempermuda Toko Padma Jaya dalam mendata barang masuk dari suplier dan barang keluar ke costumer. Metode yang digunakan dalam penelitian ini adalah deskriptif dengan melakukan observasi dan eksprimen. Alat yang digunakan adalah Flowchard dan DFD serta ERD. Pengujian system dilakukan dengan menggunakan metode Black Box, Hasil aplikasi sistem informasi persediaan barang pada Toko Bangunan Padma Jaya adalah untuk memberikan kemudahan kepada karyawan. Aplikasi ini mengunakan bahasa pemrograman VB.NET agar memudahkan karyawan dalam pencariaaan data barang dan mengolah informasi data supplier, costumer.

 

Kata kunci: Sistem Informasi, VB.NET, Supplier, Costumer, Black Box, Database.
PERANCANGAN SISTEM INFORMASI PENJUALAN KERAJINAN AKRILIK BERBASIS WEBSITE MENGGUNAKAN FRAMEWORK CODEIGNITER PADA TOKO CRAFT SEASON
Authors: Putri Adella Rifiandika , Wati Theresia
Published: October 2022

Penjualan kerajinan akrilik saat ini banyak diminati oleh banyak kalangan terutama pencinta seni akrilik. Selain model kaca akrilik yang beraneka ragam, kerajinan ini juga dapat dipadukan dengan berbagai kreativitas unik lainnya seperti handwriting, foto polaroid, lampu dan sebagainya. Toko Craft Season belum menggunakan teknologi informasi yang berkembang saat ini. Pada proses transaksi perhitungan penjualan masih menggunakan kalkulator, hal ini memungkinkan terjadinya kesalahan karena kecerobohan pemilik dalam memasukkan angka. Selain itu, semua transaksi masih dilakukan dengan cara mencatat pada buku laporan penjualan. Hal tersebut tidak efektif karena besar kemungkinan dapat terjadi kesalahan akibat hilangnya buku atau human error serta penggunaan kertas yang tidak efisien. Kemudian belum tersedianya pendataan stok produk yang menginformasikan harga, kategori, keterangan dan jumlah stok, sehingga pemilik kesulitan dalam melihat atau mencari produk tersebut. Oleh karna itu, diperlukannya teknologi informasi untuk membuat suatu sistem berbasis web menggunakan framework CodeIgniter  yang dilakukan pada penelitian ini. Metodologi penelitian yang digunakan untuk pengembangan sistem adalah metode Waterfall serta  pembuatan Unified Modelling Language (UML) untuk perancangan sistem. Hasil yang diperoleh yakni sebuah Website Penjualan Toko Craft Season yang dapat  dijalankan sesuai dengan semua fungsinya. Dengan adanya web ini, diharapkan dapat membantu baik untuk admin dalam mengelola data produk dan data pemesanan maupun pelanggan yang akan melakukan pembelian dan transaksi.
Diseño y simulación de estimadores de estado lineales y no lineales en un modelo de convertidor de potencia DC/DC
Authors: Giraldo-Ramírez Sergio Andrés , Quiroz-Pedraza Danny Alejandro , Torres-Sánchez Anderson Sebastián , Botero-Castro Héctor Antonio
Published: October 2022

La estimación de estado en convertidores electrónicos de potencia es una alternativa interesante para obtener de manera indirecta algunas variables que son difíciles de medir, debido a los costos de los sensores o a las limitaciones impuestas por los ruidos de medición.  Por lo tanto, en este artículo se realiza el diseño de tres estimadores de estado lineales y tres no lineales para un modelo de convertidor boost DC/DC, con el fin de verificar la conveniencia de usar solo estimadores no lineales como solución al problema de estimación de la corriente del convertidor. Adicionalmente, se prueba mediante simulación el comportamiento de estos estimadores en el software Matlab.

The state estimation in power electronic converters is an interesting alternative to obtain indirectly some variables that are difficult to measure, due to sensor costs or limitations imposed by measurement noise.  Therefore, in this paper we design three linear and three nonlinear state estimators for a DC/DC boost converter model, in order to verify the convenience of using only nonlinear estimators as a solution to the converter current estimation problem. Additionally, the behavior of these estimators is tested by simulation in Matlab software.
Allergen-Specific Immunotherapy
Authors: Steveling-Klein Esther Helen
Published: October 2022

Allergen-specific immunotherapy remains the only causal treatment of allergic disease to date. Its efficacy in symptom reduction was demonstrated in double blind, placebo-controlled studies of allergic rhinoconjunctivitis, allergic asthma, and Hymenoptera venom hypersensitivity, including long-term effects after discontinuation of treatment. In addition, immunotherapy decreases the risk of developing new sensitisations to aeroallergens in monosensitised patients and allergic asthma in patients with mere allergic rhinitis. The mechanism of immunotherapy entails redirection of the T lymphocyte response from a T helper cell Type 2 phenotype in favour of induction of regulatory T cells and/or immune deviation toward a T helper cell Type 1 phenotype, with resulting inhibition of downstream effector pathways and induction of immunoglobulin G-associated blocking antibodies. Two main application forms are used in clinical practice: subcutaneous immunotherapy and sublingual immunotherapy. The advantage of subcutaneous immunotherapy is its proven efficacy over a broad range of indications. Disadvantages are systemic allergic reactions and inconvenience for the patient due to frequent doctor visits. Sublingual immunotherapy has been shown to result in less systemic allergic reactions and may be more convenient due to home application; however, efficacy has only been proven for allergic rhinitis. For clinicians, the adherence to practice guidelines and thorough knowledge of allergen products, application routes, indications, immunomodulatory mechanisms, efficacy, safety, and cost-effectiveness is important for successful treatment and will be addressed in this review article.
Adjuvants in Allergy: Elevating Efficacy
Authors: Mughal Tabasum
Published: October 2022

This symposium provided an overview of the current and future technologies and treatments used in the field of allergen immunotherapy (AIT). Prof Ralph Mösges explored the concept of pre-seasonal immunotherapy in overcoming the problem of recurrent allergy, focussing on the use of Pollinex® Quattro versus the use of symptomatic treatment according to current guidelines. The use and mechanisms of adjuvants was explored by Prof Randolf Brehler, who discussed the use of adjuvants in AIT including delivery systems, immunopotentiators, and targeted delivery systems to facilitate optimum immune responses with the potential of a lower injection burden and increased efficacy of treatment. Prof Thomas Kündig concluded the symposium with an overview of the future of AIT and the use of virus-like particles (VLP) in harnessing the innate immune system response to protect against allergens.
The China-North Korea Alliance in an Era of Renewed Strategic Competition
Authors: Sampson Gary
Published: October 2022

2021 marked the 60th anniversary of the Sino-North Korean Mutual Aid and Cooperation Friendship Treaty, signed in Beijing on July 11, 1961. Renewed every 20 years, the treaty remains in force today. Moreover, it is the only formal defense treaty Beijing or Pyongyang have with any other country. This poster examines the conditions surrounding the treaty's initial negotiations and establishment and contrasts that with circumstances upon its fourth renewal in 2021. Even in the face of significant changes in the strategic environment for both states over the past six decades, the deal has stood the test of time. Yet, despite this endurance, questions remain. For example, how does this seemingly legacy formal treaty square with a contemporary view from Beijing that eschews formal treaties in favor of less constraining mechanisms for international diplomacy, commerce, and possibly even defense, such as the Belt and Road Initiative?
Presidentialism with Parliamentarian Constitutionalism in Brazil: the Inquiry of the End of the World and unchecked judicial imbalances
Authors: Santos Diogo , de Jesus Thiago Allisson Cardoso , Sanatana Guilherme Saldanha , Andrade Euller Tácito
Published: October 2022

Brazil’s Supreme Court has launched and presided over investigation procedures on alleged fake news. The so-called “Inquiry of the End of the World” (Inquérito do Fim do Mundo) was initiated by the President of the Court Justice Toffoli, overseen by another member of the Court Justice Moraes (also rapporteur). Brazil’s Constitution require different acts to be performed by different actors. By due process, the police investigate, prosecutors accuse, and judges judge. In the Inquiry of the End of the World, judges investigate, prosecute and judge. In a surprisingly evident festival of illegal acts, the rapporteur ordered searches and seizures, censorship, and arrests. Is Brazil’s Supreme Court stepping out of its constitutional mandate and limits? What impacts can such developments have on Brazilian Checks and Balances? How does this phenomenon fit within traditional literature on Coalitional Presidentialism in Latin America, especially Brazil?
Pandemic, Governors, and Public Opinion: The Effect of COVID-19 Cases and Deaths on Public Support for America’s Governors
Authors: Safarpour Alauna , Baum Matthew
Published: October 2022

Research in American foreign policy holds that the public’s support for war significantly depends on the number of US casualties in the conflict. While a pandemic is clearly not a war, many observers characterized the COVID-19 pandemic using the metaphor of wartime. Has the American public’s response to pandemic-related casualties followed similar patterns to those found in the literature on public opinion and war? In this study, we assess the public’s responsiveness to COVID-19 casualties at different stages in the pandemic. Utilizing two large, 50-state surveys conducted during the two largest COVID surges, we test several hypotheses from the public opinion and war literature, including that proximity – spatial and temporal – influences public responses and that the public becomes desensitized to casualties over time. We find that in many respects, the public’s response to the pandemic does indeed mirror the patterns found by scholars studying public opinion and war.
Gödel mathematics versus Hilbert mathematics. I. The Gödel incompleteness (1931) statement: axiom or theorem?
Authors: Penchev Vasil
Published: October 2022

The present first part about the eventual completeness of mathematics (called “Hilbert mathematics”) is concentrated on the Gödel incompleteness (1931) statement: weather it is an axiom rather than a theorem inferable from the axioms of (Peano) arithmetic, (ZFC) set theory, and propositional logic. The main argument consists in the contradiction of the axiom of induction in arithmetic and the axiom of infinity in set theory. Thus, the pair of arithmetic and set are similar to Euclidean and non-Euclidean geometries distinguishably only by the Fifth postulate: correspondingly, by the axiom of finiteness (induction) versus that of finiteness being idempotent negations to each other. The axiom of choice transforms any set in a well-ordering either necessarily finite according to the axiom of induction or also optionally infinite according to the axiom of infinity. The Gödel incompleteness statement relies on the contradiction of the axioma of induction and infinity.
Texter om forskare kan belysa naturvetenskapernas karaktär
Authors: Bossér Ulrika
Published: October 2022

Populärvetenskapliga artiklar om verksamma forskare kan vara en resurs i undervisningen om naturvetenskapernas karaktär. En ny studie visar att det kan erbjuda elever en nyanserad bild av naturvetenskaplig forskning och motverka stereotypa uppfattningar. Det kan också öka elevers intresse och motivation eftersom verksamma forskare kan bli förebilder för eleverna.
The psychological and social impacts of museum-based programmes for people with a mild-to-moderate dementia: a systematic review
Authors: Zeilig Hannah , Dickens Laura , Camic Paul M.
Published: October 2022

The importance of museum-based interventions for people with demen­tia has been increasingly appreciated. Yet, there is relatively little known about the psychological and social impacts of these interventions. To address this, the authors undertook a systematic review to elucidate these aspects of museum-based programmes for people with mild-to-moder­ate dementia. Four electronic databases were searched systematically, and eleven studies were included. Key findings were synthesised thematically, and six themes were identified: mood and enjoyment, subjective wellbe­ing, personhood, cognition, engagement, and social outcomes. These pos­itive findings suggest that museum-based interventions for people with a mild-to-moderate dementia can offer a range of valuable benefits. This review also clarified that further mixed-methods studies and wait-list controlled studies, to clarify the factors that benefits may be attributed to, will contribute towards a more robust evidence base. In turn, this would positively impact funding and guide policy in this area.
Новые аспекты изучения женской телесности в карельской культуре
NEW ASPECTS IN THE STUDY OF FEMALE CORPOREALITY IN KARELIAN CULTURE
Authors: Litvin J. V.
Published: October 2022

В региональной российской историографии сохраняются лакуны, связанные с изучением женской повседневности, особенно, телесности и сексуальности. Подобное обстоятельство обусловлено как спецификой традиционной культуры, которая табуировала разговор на данную тему, так и научными традициями, долгое время обходившими стороной указанную проблематику. В данной статье на основе комплекса опубликованной научной литературы и историко‑этнографических источников представлены некоторые малоизученные аспекты в жизни карельской крестьянки, связанные с физическим и «культурным» телом. К таковым отнесены: менархе, визуальные маркеры половозрелости, первая брачная ночь, рождение первенца и амбивалентное положение роженицы, завершение фертильного периода. Источниковую базу статьи также составляют авторские экспедиционные материалы, собранные у карелок, рожденных в 1920–1950‑х гг. Несмотря на более поздний период фиксации, использование этих сведений позволяет раскрыть ранее неизвестные (подчас, довольно эмоциональные) стороны женской повседневности. Порядок изложения материала оформлен с опорой теорию обрядов жизненного цикла, на переход женщины из одного социального статуса в другой. В тоже время автор понимает условность данной категоризации, поскольку женская телесность не ограничивалась рождением, браком и смертью, а имела множество нюансов внутри классической «триады».
In regional Russian historiography, gaps remain associated with the study of women’s everyday life. This is due both to the specifics of traditional culture, which tabooed conversation on these topics and to scientific traditions, which for a long time bypassed these problems. This article presents the results of archival research and fieldwork. It investigates some understudied aspects of the life of a Karelian peasant woman, connected with the physical and «cultural» body and the emotional sphere. These include menarche, visual markers of sexual maturity, the first wedding night, the first childbirth, and the ambivalent position of a woman in labor, the end of the fertile period. One of the article sources is the author’s expedition materials collected from women born in the 1920s‑1950s. Despite the retrospective nature of interviews, this information reveals previously unknown (sometimes quite emotional) aspects of women’s everyday life. The material is presented according to the rituals of the life cycle, which mark the transition of a woman from one social status to another. At the same time, the author acknowledges the conventionality of this categorization since female corporeality was not limited to birth, marriage, and death but had many other aspects.
Трансформация традиционной нательной мужской одежды мордвы
TRANSFORMATION OF TRADITIONAL MORDOVIAN MEN’S UNDERWEAR CLOTHING
Authors: Shchankina L. N. , Egorova O. V.
Published: October 2022

Статья посвящена изучению изменения нательного мужского костюма как важнейшего элемента материальной культуры мордовского народа. Мордва была первым крупным по численности народом, присоединившимся к России в середине XVI в. С этого периода начинается христианизация мордвы, сыгравшая существенную роль в ее сближении с русским народом. В результате тесных межкультурных контактов с соседями, особенно с русскими, в мужской одежде мордвы нашли отражение элементы других культур, верований, обрядов и традиций. Наибольшие изменения традиционного мордовского костюма наблюдались в конце XIX — первой четверти XX века. Они связаны с использованием для изготовления одежды фабричных материалов, а также с заимствованиями отдельных компонентов костюма у соседних народов, проживавших в Волго‑Уралье. Результат анализа источниковой и литературной базы показал, что наиболее подробно в этнографических источниках и произведениях мордовского фольклора описаны особенности изготовления и, в частности, покроя рубахи, выбора цвета, материала и подбора одежды по сезону.
The article aims to study the changes in the male underwear clothing as an essential element of the material culture of the Mordovian people. Mordva was the first large ethnic group to join Russia in the middle of the XVI century. The Christianization of the Mordva started from that moment on and played a significant role in its rapprochement with the Russian people. As a result of close intercultural contacts with different ethnic groups, especially with Russians, the Mordovian men’s costume reflected influences of other cultures, beliefs, rites, and traditions. The most notable changes in the traditional Mordovian costume were observed in the late XIX — fi rst quarter of the XX century and are associated with the use of factory‑made fabric and borrowing individual costume elements from neighboring peoples living in Volga‑Urals. The study of the literature on the topic showed that ethnographic sources and Mordovian folklore provide the most detailed descriptions of the manufacture of shirts, color selection, material, and clothing choice according to the season.
Произведения художественной литературы как источник для изучения народной медицины восточных славян Дальнего Востока России
FICTION AS A SOURCE OF INFORMATION ABOUT TRADITIONAL MEDICINE AMONG THE EASTERN SLAVS IN THE RUSSIAN FAR EAST
Authors: Popovkina G. S.
Published: October 2022

В результате массового переселения из центральных регионов на Дальний Восток восточные славяне оказались в непривычном этнокультурном окружении, новой экологической нише. Кроме трудностей хозяйственного освоения новой территории, переселенцы столкнулись с нехваткой медицинской помощи, вследствие чего были особенно востребованы приемы народной медицины, адаптированные к дальневосточным условиям. Несмотря на глубокие исследования отдельных аспектов народно‑медицинской практики переселенцев, до сих пор не проводилось комплексное изучение их лекарских традиций, в этнографической литературе мало подробностей освоения таёжного сырья в лечебных целях. В статье проверяется гипотеза о возможности использования произведений художественной литературы в качестве источника по изучению народной медицины восточных славян‑дальневосточников. Для анализа выбраны произведения писателей‑дальневосточников, чья деятельность тесно связана с путешествиями и изучением родного края. При выборе произведений учитывались особенности личности писателя, вехи его биографии, специфика писательского стиля, например, отношение к описанию подробностей повседневной жизни. Сделан вывод, что литературные произведения дальневосточных писателей могут явиться дополнительным источником для изучения народной медицины славянских переселенцев в их взаимодействии с местным населением, другими переселенцами, выявления особенностей адаптации к новой культурной и экологической среде, а в некоторых случаях выступить причиной для пересмотра и уточнения уже имеющихся сведений.
After the mass migration from the central regions to the Far East, the Eastern Slavs found themselves in an unusual ethnocultural and ecological environment. The new settlers faced a lack of medical care, so the methods of traditional medicine adapted to the Far Eastern conditions were in particular demand. The medical traditions of migrants have not been studied comprehensively yet, although there have been profound studies of individual aspects of folk medical practices. The article attempts to use fiction as a source for studying traditional medicine of the Eastern Slavs in the Far East. For the analysis we selected the works of writers from the Far East who traveled and studied their native land. It is concluded that fiction by Far Eastern writers can be an additional source of information about folk medicine of Slavic settlers in their interaction with the local population, other settlers, and adaptation to a new cultural and ecological environment. In some cases, fiction can encourage revision of the already known information.
Анализ неоязычества и национализма в антропологии Рене Жирара
NEOPAGANISM AND NATIONALISM IN THE ANTHROPOLOGY OF RENE GIRARD
Authors: Kutyavin N. A.
Published: October 2022

Данная статья посвящена рассмотрению теоретического наследия антрополога Рене Жирара. В тексте проанализированы размышления Жирара о таких явлениях как национализм и неоязычество. Рассмотрены его представления о генезисе данных феноменов, а также о месте и роли таких жирардианских концептов, как «миметическое желание», «миметическое насилие» и «обеспокоенность жертвами» в их становлении. Как можно узнать из работ Жирара, он видел истоки национализма как идеологии в распространении обезличенности и ресентимента в современных обществах, поскольку вместе с распространением эгалитаризма в них стало повсеместным «миметическое соперничество». Представления Жирара о неоязычестве можно обнаружить в работе «Я вижу Сатану, падающего, как молния», где он выделяет левое и правое направления в неоязычестве, в зависимости от их отношения к культурному тренду «обеспокоенности жертвами». Также в статье предлагается опыт применения гипотез и концепций Жирара в исследовании русского неоязычества, с примерами из истории и текстов неоязыческих идеологов, таких как В. Н. Емельянов, Г. П. Якутовский и Н. Н. Сперанский.
This article examines the theoretical legacy of Rene Girard, the French anthropologist. The text analyzes Girard’s reflections on such phenomena as nationalism and neopaganism. The author examines his ideas about the genesis of these phenomena and the role of such girardian concepts as «mimetic desire», «mimetic violence» and «concern for victims» in their formation. As we learn from the work of Girard, he saw the origins of nationalism as an ideology in the spread of indiscernibility and resentment in modern societies since, along with the spread of egalitarianism, «mimetic rivalry» became ubiquitous in them. Girard’s views on neopaganism can be found in «I See Satan Fall Like Lightning», where he distinguishes left and right wings in neopaganism, depending on their attitude to the cultural trend of «concern for victims». The article also offers an attempt to apply Girard’s hypotheses and concepts to the study of Russian neopaganism, with examples from the history and texts of neopagan ideologues such as V. N. Emelyanov, G. P. Yakutovsky and N. N. Speransky.
MicroRNA-383: A tumor suppressor miRNA in human cancer
Authors: Jafarzadeh Abdollah , Noori Majid , Sarrafzadeh Shaghayegh , Tamehri Zadeh Seyed Saeed , Nemati Maryam , Chatrabnous Nazanin , Jafarzadeh Sara , Hamblin Michael R , Jafari Najaf Abadi Mohammad Hassan , Mirzaei Hamed
Published: October 2022

Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer. MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the mRNA of some pro-tumor genes to attenuate several cancer-related processes, including cell proliferation, invasion, migration, angiogenesis, immunosuppression, epithelial-mesenchymal transition, glycolysis, chemoresistance, and the development of cancer stem cells, whilst promoting apoptosis. Functionally, miR-383 operates as a tumor inhibitor miRNA in many types of cancer, including breast cancer, hepatocellular carcinoma, gastric cancer, pancreatic cancer, colorectal cancer, esophageal cancer, lung cancer, head and neck cancer, glioma, medulloblastoma, melanoma, prostate cancer, cervical cancer, oral squamous cell carcinoma, thyroid cancer, and B-cell lymphoma. Both pro-tumor and anti-tumor effects have been attributed to miR-383 in ovarian cancer. However, only the pro-tumor effects of miR-383 were reported in cholangiocarcinoma. The restoration of miR-383 expression could be considered a possible treatment for cancer. This review discusses the anti-tumor effects of miR-383 in human cancers, emphasizing their downstream target genes and potential treatment approaches.
Nramp: Deprive and conquer?
Authors: Cellier M. F. M.
Published: October 2022

Solute carriers 11 (Slc11) evolved from bacterial permease (MntH) to eukaryotic antibacterial defense (Nramp) while continuously mediating proton (H+)-dependent manganese (Mn2+) import. Also, Nramp horizontal gene transfer (HGT) toward bacteria led to mntH polyphyly. Prior demonstration that evolutionary rate-shifts distinguishing Slc11 from outgroup carriers dictate catalytic specificity suggested that resolving Slc11 family tree may provide a function-aware phylogenetic framework. Hence, MntH C (MC) subgroups resulted from HGTs of prototype Nramp (pNs) parologs while archetype Nramp (aNs) correlated with phagocytosis. PHI-Blast based taxonomic profiling confirmed MntH B phylogroup is confined to anaerobic bacteria vs. MntH A (MA)’s broad distribution; suggested niche-related spread of MC subgroups; established that MA-variant MH, which carries ‘eukaryotic signature’ marks, predominates in archaea. Slc11 phylogeny shows MH is sister to Nramp. Site-specific analysis of Slc11 charge network known to interact with the protonmotive force demonstrates sequential rate-shifts that recapitulate Slc11 evolution. 3D mapping of similarly coevolved sites across Slc11 hydrophobic core revealed successive targeting of discrete areas. The data imply that pN HGT could advantage recipient bacteria for H+-dependent Mn2+ acquisition and Alphafold 3D models suggest conformational divergence among MC subgroups. It is proposed that Slc11 originated as a bacterial stress resistance function allowing Mn2+-dependent persistence in conditions adverse for growth, and that archaeal MH could contribute to eukaryogenesis as a Mn2+ sequestering defense perhaps favoring intracellular growth-competent bacteria.
Solar light induced photocatalytic degradation of tetracycline in the presence of ZnO/NiFe2O4/Co3O4 as a new and highly efficient magnetically separable photocatalyst
Authors: Doosti Mohammadreza , Jahanshahi Roya , Laleh Shaghayegh , Sobhani Sara , Sansano José Miguel
Published: October 2022

In this study, a new solar light-driven magnetic heterogeneous photocatalyst, denoted as ZnO/NiFe2O4/Co3O4, is successfully prepared. FT-IR, XPS, XRD, VSM, DRS, FESEM, TEM, EDS, elemental mapping, and ICP analysis are accomplished for full characterization of this catalyst. FESEM and TEM analyses of the photocatalyt clearly affirm the formation of a hexagonal structure of ZnO (25–40 nm) and the cubic structure of NiFe2O4 and Co3O4 (10–25 nm). Furthermore, the HRTEM images of the photocatalyst verify some key lattice fringes related to the photocatalyt structure. These data are in very good agreement with XRD analysis results. According to the ICP analysis, the molar ratio of ZnO/NiFe2O4/Co3O4 composite is obtained to be 1:0.75:0.5. Moreover, magnetization measurements reveals that the ZnO/NiFe2O4/Co3O4 has a superparamagnetic behavior with saturation magnetization of 32.38 emu/g. UV-vis DRS analysis indicates that the photocatalyst has a boosted and strong light response. ZnO/NiFe2O4/Co3O4, with band gap energy of about 2.65 eV [estimated according to the Tauc plot of (αhν)2vs. hν], exhibits strong potential towards the efficacious degradation of tetracycline (TC) by natural solar light. It is supposed that the synergistic optical effects between ZnO, NiFe2O4, and Co3O4 species is responsible for the increased photocatalytic performance of this photocatalyst under the optimal conditions (photocatalyst dosage = 0.02 g L−1, TC concentration = 30 mg L−1, pH = 9, irradiation time = 20 min, and TC degradation efficiency = 98%). The kinetic study of this degradation process is evaluated and it is well-matched with the pseudo-first-order kinetics. Based on the radical quenching tests, it can be perceived that •O2− species and holes are the major contributors in such a process, whereas the •OH radicals identify to have no major participation. The application of this methodology is implemented in a facile and low-cost photocatalytic approach to easily degrade TC by using a very low amount of the photocatalyst under natural sunlight source in an air atmosphere. The convenient magnetic isolation and reuse of the photocatalyst, and almost complete mineralization of TC (based on TOC analysis), are surveyed too, which further highlights the operational application of the current method. Notably, this method has the preferred performance among the very few methods reported for the photocatalytic degradation of TC under natural sunlight. It is assumed that the achievements of this photocatalytic method have opened an avenue for sustainable environmental remediation of a broad range of contaminants.
Solution-processed thickness engineering of tellurene for field-effect transistors and polarized infrared photodetectors
Authors: Chen Fangfang , Cao Dingwen , Li Juanjuan , Yan Yong , Wu Di , Zhang Cheng , Gao Lenan , Guo Zhaowei , Ma Shihong , Yu Huihui , Lin Pei
Published: October 2022

Research on elemental 2D materials has been experiencing a renaissance in the past few years. Of particular interest is tellurium (Te), which possesses many exceptional properties for nanoelectronics, photonics, and beyond. Nevertheless, the lack of a scalable approach for the thickness engineering and the local properties modulation remains a major obstacle to unleashing its full device potential. Herein, a solution-processed oxidative etching strategy for post-growth thickness engineering is proposed by leveraging the moderate chemical reactivity of Te. Large-area ultrathin nanosheets with well-preserved morphologies could be readily obtained with appropriate oxidizing agents, such as HNO2, H2O2, and KMnO4. Compared with the conventional physical thinning approaches, this method exhibits critical merits of high efficiency, easy scalability, and the capability of site-specific thickness patterning. The thickness reduction leads to substantially improved gate tunability of field-effect transistors with an enhanced current switching ratio of ∼103, promoting the applications of Te in future logic electronics. The response spectrum of Te phototransistors covers the full range of short-wave infrared wavelength (1–3 μm), and the room-temperature responsivity and detectivity reach 0.96 AW-1 and 2.2 × 109 Jones at the telecom wavelength of 1.55 μm, together with a favorable photocurrent anisotropic ratio of ∼2.9. Our study offers a new approach to tackling the thickness engineering issue for solution-grown Te, which could help realize the full device potential of this emerging p-type 2D material.
Adding a piece to the puzzle of Latin American blood donors and the potential risk of Trypanosoma cruzi transmission in Germany
Authors: Ullrich Julian , Guertler Lutz , Quenzel Ernst , Weinauer Franz , Rößler Dieter , Kalus Ulrich , Pruß Axel , Albajar-Viñas Pedro , Pritsch Michael
Published: October 2022

Introduction

Chagas disease (CD) is caused by the Trypanosoma cruzi (T. cruzi) infection and has become a global health concern due to population mobility, as well as non-vectorial transmission routes. Several countries outside Latin America (LA) have reported transfusion-associated transmission, but equivalent studies in Germany are lacking. This study aims to collect first data on the risk of transfusion associated transmission as well as LA blood donors originating from CD endemic countries in Germany

Materials and methods

A total of 305 blood donors who were assumed to be at risk for T. cruzi infection were retrospectively (267) as well as prospectively (38) selected at German blood donation sites in Bavaria and Berlin, and all retrospectively as well as 27 prospectively selected were serologically screened. Prospective study subjects additionally filled out a questionnaire.

Results

All samples tested seronegative for T. cuzi specific antibodies. Prospectively enrolled study subjects all had high socio-economic status including good education. Knowledge regarding CD was limited but willingness to donate frequently was high. Blood donation rates from donors born in LA countries seem to increase from 2015.

Discussion

Although no transfusion associated T. cruzi infection has been documented in Germany, it has likely already happened unnoticed, or will do in the near future. Performing risk-adapted serology-based blood donor screenings in Germany could avoid transfusion-associated transmission events as well as contribute to active case detection. Moreover, larger, and ongoing studies are needed to increase the evidence base as well as end the neglect of CD in Germany.
Metabolic syndrome as a common comorbidity in adults with hypothalamic dysfunction
Authors: Xu Zhuoran , Ke Xiaoan , Yuan Xianxian , Wang Linjie , Duan Lian , Yao Yong , Deng Kan , Feng Feng , You Hui , Lian Xin , Wang Renzhi , Yang Hongbo , Pan Hui , Lu Lin , Zhu Huijuan
Published: October 2022

Objective

Hypothalamic dysfunction (HD) results in various endocrine disorders and is associated with an increased risk of metabolic comorbidities. This study aimed to analyze the clinical characteristics and metabolic abnormalities of adults with HD of various causes.

Methods

This study retrospectively reviewed adults with HD treated at our center between August 1989 and October 2020. Metabolic characteristics of patients were compared to those of age-, sex-matched lean, and body mass index (BMI)-matched controls.

Results

Temperature dysregulation (61.0%) was the most common hypothalamic physiological dysfunction. At least one anterior pituitary hormone deficiency was observed in 50 patients (84.7%), with hypogonadotropic hypogonadism being the most frequently observed. Metabolic syndrome was confirmed in 31 patients (52.5%) and was significantly more prevalent in those with panhypopituitarism or overweight/obesity. Metabolic syndrome (MetS) was significantly more common in patients with HD than in both lean and BMI-matched controls (P < 0.001 and P = 0.030, respectively). Considering the components of MetS, elevated fasting glucose levels were significantly more common in patients with HD than in BMI-matched controls (P = 0.029). Overweight/obesity and panhypopituitarism were significant risk factors for MetS in the multivariate analysis on patients with HD. Moreover, in the multivariate analysis on patients and BMI-matched control, HD was a significant risk factor of MetS (P=0.035, OR 2.919) after adjusted for age, sex and BMI.

Conclusions

Temperature dysregulation and hypogonadotropic hypogonadism are the most common physiological and endocrine dysfunctions, respectively. MetS and unfavorable metabolic profiles were prevalent in adults with HD. HD was a significant risk factor of MetS after adjusted for BMI.
Highly sensitive ultra-thin optical CO2 gas sensors using nanowall honeycomb structure and plasmonic nanoparticles
Authors: Elrashidi Ali , Traversa Enrico , Elzein Basma
Published: October 2022

The carbon dioxide highly sensitive ultra-thin optical sensor using plasmonic nanoparticles distributed uniformly on the nanowall honeycomb structure with a footprint in the millimeter range is presented in this work. The zinc oxide (ZnO) honeycomb nanowall structure is grown by the pulsed laser deposition (PLD) method. Moreover, the performance of the fabricated structure as a gas nanosensor is simulated using the finite difference time domain (FDTD) method in the visible and near-infrared regions. A graphene layer is mounted on the top of the nanowall, and then, plasmonic nanoparticles are distributed on the nanowall sides. Furthermore, the effect of gas concentration on the pressure and consequently on the dielectric constant of the gas are also illustrated in this article. Red-shift in the absorption has been noticed with different refractive indices and intensity sensitivities. The obtained refractive index sensitivity of the proposed nano optical sensor is 874 nm/RIU, and the intensity sensitivity is 5,174 RIU−1 with the figure of merit of 12.5 and quality factor (Q-factor) of 281 at a carbon dioxide (CO2) concentration of 5,500 ppm. Finally, the absorbed power of the incident light is calculated using different polarization angles, from 10° to 80° with a step10°.
Definition of immune molecular subtypes with distinct immune microenvironment, recurrence, and PANoptosis features to aid clinical therapeutic decision-making
Authors: Qiang Sufeng , Fu Fei , Wang Jianjun , Dong Chunyan
Published: October 2022

Objective: Cervical cancer poses a remarkable health burden to females globally. Despite major advances in early detection and treatment modalities, some patients still relapse. The present study proposed a novel immune molecular classification that reflected distinct recurrent risk and therapeutic responses in cervical cancer.

Methods: We retrospectively collected two cervical cancer cohorts: TCGA and GSE44001. Consensus clustering approach was conducted based on expression profiling of recurrence- and immune-related genes. The abundance of immune cells was inferred via five algorithms. Immune functions and signatures were quantified through ssGSEA. Genetic mutations were analyzed by maftools package. Immunotherapeutic response was inferred via tumor mutation burden (TMB), Tumor Immune Dysfunction and Exclusion (TIDE), and Submap methods. Finally, we developed a LASSO model for recurrence prediction.

Results: Cervical cancer samples were categorized into two immune subtypes (IC1, and IC2). IC2 exhibited better disease free survival (DFS), increased immune cell infiltration within the immune microenvironment, higher expression of immune checkpoints, higher activity of immune-relevant pathways (APC co-inhibition and co-stimulation, inflammation-promoting, MHC class I, IFN response, leukocyte and stromal fractions, macrophage regulation, and TCR Shannon), and higher frequencies of genetic mutations. This molecular classification exhibited a remarkable difference with existing immune subtypes, with diverse PANoptosis (pyroptosis, apoptosis and necroptosis) features. Patients in IC2 were more likely to respond to immunotherapy and targeted, and chemotherapeutic agents. The immune subtype-relevant signature was quantified to predict patients’ recurrence risk.

Conclusion: Altogether, we developed an immune molecular classification, which can be utilized in clinical practice to aid decision-making on recurrence management.
Immunoinformatic-based design of immune-boosting multiepitope subunit vaccines against monkeypox virus and validation through molecular dynamics and immune simulation
Authors: Suleman Muhammad , Rashid Farooq , Ali Shahid , Sher Hassan , Luo Sisi , Xie Liji , Xie Zhixun
Published: October 2022

Monkeypox virus is the causative agent of monkeypox disease, belonging to an orthopoxvirus genus, with a disease pattern similar to that of smallpox. The number of monkeypox cases have robustly increased recently in several countries around the world, potentially causing an international threat. Therefore, serious measures are indispensable to be taken to mitigate the spread of the disease and hence, under these circumstances, vaccination is the best choice to neutralize the monkeypox virus. In the current study, we used immunoinformatic approaches to target the L1R, B5R, and A33R proteins of the monkeypox virus to screen for immunogenic cytotoxic T-lymphocyte (CTL), helper T-lymphocyte (HTL), and B-cell epitopes to construct multiepitope subunit vaccines. Various online tools predicted the best epitope from immunogenic targets (L1R, B5R, and A33R) of monkeypox virus. The predicted epitopes were joined together by different linkers and subjected to 3D structure prediction. Molecular dynamics simulation analysis confirmed the proper folding of the modeled proteins. The strong binding of the constructed vaccines with human TLR-2 was verified by the molecular docking and determination of dissociation constant values. The GC content and codon adaptation index (CAI) values confirmed the high expression of the constructed vaccines in the pET-28a (+) expression vector. The immune response simulation data delineated that the injected vaccines robustly activated the immune system, triggering the production of high titers of IgG and IgM antibodies. In conclusion, this study provided a solid base of concept to develop dynamic and effective vaccines that contain several monkeypox virus-derived highly antigenic and nonallergenic peptides to control the current pandemic of monkeypox virus.
Therapeutic effects of Fc gamma RIV inhibition are mediated by selectively blocking immune complex-induced neutrophil activation in epidermolysis bullosa acquisita
Authors: Haeger Swantje C. , Kridin Khalaf , Pieper Mario , Griewahn Laura , Nimmerjahn Falk , Zillikens Detlef , König Peter , Ludwig Ralf J. , Hundt Jennifer E.
Published: October 2022

Epidermolysis bullosa acquisita (EBA) is a subepidermal autoimmune bullous disease caused by autoantibodies targeting type VII collagen (COL7). It is characterized by inflammation and subepidermal blistering mainly through immune complex (IC)-mediated activation of neutrophils. In experimental EBA, binding of neutrophils to ICs in the skin and induction of clinical disease depends on the expression of the Fc gamma receptor (FcγR) IV. As activating FcγR mediate both neutrophil extravasation and activation, we used multiphoton imaging to obtain further insights into the mechanistic contribution of FcγRIV in the pathogenesis of EBA. First, we demonstrated that blocking FcγRIV function completely protects LysM-eGFP mice against induction of antibody transfer-induced EBA. To visualize the interactions of anti-COL7 IgG and neutrophils in vivo, fluorescently labeled anti-COL7 IgG was injected into LysM-eGFP mice. Multiphoton microscopy was sequentially performed over a period of 8 days. At all time points, we observed a significantly higher extravasation of neutrophils into the skin of mice treated with anti-FcγRIV antibody compared to controls. However, the percentage of detected neutrophils localized to the target antigen along the dermal-epidermal junction was comparable between both groups. Additionally, reactive oxygen release and migration in vitro assay data demonstrate that FcγRIV antibody treatment inhibits the activation, but not the migration, of neutrophils. Our findings underscore the importance of advanced in vivo imaging techniques to understand the complexity of IC-mediated neutrophil-dependent inflammation, and indicate that the therapeutic utility of FcγRIV blockade is achieved through impairment of IC-mediated neutrophil activation.