bluuebunny/crossref_metadata_2025 huggingface dataset:
Disconnected Out of Passion: Relationship Between Social Alienation and Obsessive Passion
Authors: Lobato Roberto M. , García-Coll Josep , Moyano Manuel
Published: April 2022

Violent radicalization continues to be a global problem. One of the main proposals for understanding radicalization and support for political violence is based on social alienation as a trigger. That is, individuals who feel alienated from society try to get out of this situation by using violence, if necessary. However, social alienation alone is not enough to explain radicalization. Therefore, we propose that social alienation interacts with other factors to foster radicalization. Particularly, we propose that obsessive passion, an internal compulsion that leads a person to engage in an activity even when they should not, is one of the interacting factors. Following previous literature, we hypothesized that higher social alienation predicts support for political violence to a greater extent the higher the obsessive passion. To test this hypothesis, we performed two studies in which the cause of passion varied (religion: N = 652 and family: N = 873). Both studies assessed social alienation, harmonious and obsessive passion, and support for political violence. The results showed a significant increase in the effect of social alienation on support for political violence when obsessive passion was higher, even controlling by harmonious passion. These results highlight the importance of considering other variables related to social alienation that could facilitate radicalization processes, particularly maintaining an obsessive passion for a cause when one feels a social disconnection. The theoretical and practical implications of these results are discussed given their contributions to prevention based on work on feelings of social disconnection and harmonization of causes.
Do Faith Friendly Workplaces Increase Well-Being?
Authors: Terry Paul E.
Published: May 2022

Many will draw distinctions between finding your purpose and tapping into spirituality. And many more are quick to point out that they are spiritual but not religious. This predictable definitional dynamic makes me doubtful that adoption of purpose finding strategies will be the gateway to unlocking the ambivalence and stigma related to sharing one’s faith in company settings. Drawing from tenets that drive social epidemics, wellness professionals and faith leaders travel in ‘closed circles’ and it will take ‘connectors’ with ties in both circles to spread the idea that workplace wellness and faith traditions can have positive synergies. Healthy People 2030 defines health and well-being as “how people think, feel, and function—at a personal and social level—and how they evaluate their lives as a whole.” This editorial describes components of faith friendly organizations and argues that employee resource groups and trends in diversity, equity and inclusion initiatives could be a catalyst for greater openness to including people’s faith traditions as a part of bringing their whole selves to work.
A two-dimensional mathematical model of tumor angiogenesis with CD147
Authors: Sreedaran Bhooma , Ponnuswamy Vimala
Published: April 2022

Tumor angiogenesis is the tumor’s inherent blood supply system which is crucial for the growth of tumor. Extracellular Matrix Metallo Proteinases Inducer (EMMPRIN)/Cluster of Differentiation 147 (CD147) is found in high levels on tumor surfaces. This study focuses on these elevated levels of CD147 and the effect it has on tumor angiogenesis. The present article develops a Two-Dimensional Mathematical Model of Tumor Angiogenesis taking into account the CD147 molecule. The effects of CD147 on Tumor Angiogenesis Factors (TAFs), fibronectin and Matrix Metallo Proteinases (MMPs) are also incorporated. The results have been obtained through COMSOL Multiphysics 5.4 software. The results show that CD147 is responsible for swifter angiogenesis, calling for targeting this molecule in anti-angiogenic strategies. The present model is validated with the existing theoretical and experimental results.
HIV pre-exposure prophylaxis: assessment of acceptability among members of HIV serodiscordant/serostatus unknown couples
Authors: Bracho-Sanchez Edith , Stonbraker Samantha , Halpern Mina , Wood Sarah , Lowenthal Elizabeth
Published: April 2022

Background:

Pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection but is not yet widely available in resource-limited settings such as the Dominican Republic. We aimed to ascertain PrEP acceptability among people living with HIV in the Dominican Republic who are part of HIV serodiscordant partnerships and understand relationships between PrEP acceptability, HIV stigma, and intimate partner violence.Methods: A cross-sectional survey of people in care for HIV infection included acceptability-related questions and assessments of HIV stigma and intimate partner violence. We also explored the expected impact of PrEP on HIV disclosure rates and fertility intentions.Results: Of the 100 participants, 74% had been in their current partnership for >1 year; 38% had not disclosed to their partner; 29% reported condomless sex, and 23% reported sex with multiple partners. PrEP was highly acceptable with 84% of participants saying they were “very likely” to offer PrEP to their partner if available and 21% stating it would allow them to have more children. Of those who had not disclosed to their partner, 71% stated PrEP would help them do so. No relationship was found between PrEP acceptability, HIV stigma, and intimate partner violence. However, higher than expected rates of PrEP acceptability limited the power of these analyses.Conclusion: Pre-exposure prophylaxis was considered to be highly acceptable among people living with HIV in the Dominican Republic who are part of serodiscordant partnerships.
‘This Foul Substance Is Called History’: Anglo-Indian Memory-narratives and (Mis)remembrances in Sealy’s The Trotter-nama
Authors: Raj Merin Simi
Published: May 2022

This article demonstrates how, through various acts of remembrance and recovery, The Trotter-nama makes it possible to challenge as well as subvert dominant historiographical constructions about the Anglo-Indian past and their lived experiences. Thus it argues that the interconnectedness of memory, history and fiction could initiate newer possibilities towards reclaiming identities that are historiographically silenced, forgotten or elided.
A 114% Cigarette Tax Hike and Drinking Behavior: Results From Nationally Representative Longitudinal Panel Data in Korea
Authors: Lee Boram , Seo Dong-Chul
Published: April 2022

This study investigated whether or not drinking behavior changed among Korean adult smokers after a 114% cigarette tax hike in 2015. Data were drawn from waves 9 to 12 (collected yearly from 2014 to 2017) of the nationally representative longitudinal study, the Korean Welfare Panel Study. Korean adults who were ≥19 years comprised the analysis sample (N = 10 875). We applied a difference-in-differences approach to compare drinking behavior before and after the tax increase among three groups (i.e., quitters, continued smokers, and nonsmokers). We found that alcohol drinking significantly decreased among those who quit smoking after the tax increase, compared with nonsmokers ( P = .022). Our findings support that a cigarette tax increase may have the beneficial spillover influence of reduction in drinking as well as smoking if the tax increase can induce smokers to quit, but such positive spillover influence may be short-term or null for continued smokers.
How to support the design of active lives that meet the challenges of the twenty-first century (economy, ecology and politics)?
Authors: Guichard Jean
Published: April 2022

In recent decades support for the design of active lives has generally been conceived as an aid intended for qualified workers to manage their careers on the labor market. This conception is, for example, the basis of the official definition of this support published by the Council of the European Union in 2008. However, alternative definitions insist on all of the dimensions of any active life and wonder about the the view of the future to which such support refers. The very serious current crisis of the “anthropo-capitalocene” leads precisely to a focus on reflections on this future. Such a concern is at the heart of new interventions to support the design of active lives. It deals with the following question: by what forms of active life can we achieve the objectives of sustainable and equitable development defined by the major international organizations and the specialists in these matters? Developing this renewal of support for the design of active lives involves specifying the conceptual field on which to base it, experimenting with new interventions and setting up operating devices to propose them to the public.
Fostering Learning and Reciprocity in Interdisciplinary Research
Authors: Lorenzetti Liza , Jacobsen Michele , Lorenzetti Diane L. , Nowell Lorelli , Pethrick Helen , Clancy Tracey , Freeman Georgina (Gina) , Oddone Paolucci Elizabeth
Published: May 2022

While cohesive teams are essential to advancing interdisciplinary research, few frameworks exist to guide team development. In this article, eight academic women adopt a participatory process of inter-relational reflexivity to reflect upon our interdisciplinary research and propose a best-practice framework for sustained effectiveness of interdisciplinary collaboration.
Minimal Clinically Important Differences of PROMIS PF in Ankle Fracture Patients
Authors: Myhre Luke , Kellam Patrick , Dekeyser Graham , Li Haojia , Zhang Yue , Cizik Amy M. , Haller Justin
Published: April 2022

Background:

Evaluating the minimal clinically important differences (MCIDs) in patient-reported outcome scores is essential for use of clinical outcomes data. The purpose of the current study was to calculate MCID of Patient Reported Outcome Information System Physical Function (PROMIS PF) scores for ankle fracture patients.

Methods:

All patients who underwent operative fixation for ankle fractures at a single level 1 trauma center were identified by Current Procedural Terminology code. PROMIS PF scores were collected. Patients had to complete an anchor question at 2 time points postoperatively to be included in this study. Anchor-based and distribution-based MCIDs were calculated.

Results:

A total of 331 patients were included in the distribution-based analysis, and 195 patients were included in the anchor-based analysis. Mean age was 45.3 years (SD 17.5), and 59.4% of participants were female. MCID for PROMIS PF scores was 5.05 in the distribution-based method and 5.43 in the anchor-based method.

Conclusion:

This study identified MCID values based on 2 time points postoperatively for PROMIS PF scores in the ankle fracture population. Both methods of MCID calculation resulted in equivalent MCIDs. This can be used to identify patients outside the normal preoperative and postoperative norms and may help to make clinically relevant practice decisions.

Level of Evidence:

Level I, diagnostic study, testing of previously developed diagnostic measure on consecutive patients with reference standard applied.
Biliteracy as Property: Promises and Perils of the Seal of Biliteracy
Authors: Chang-Bacon Chris K. , Colomer Soria E.
Published: May 2022

A majority of U.S. states have established a “Seal of Biliteracy” (SoBL) to recognize students’ multilingualism. Primarily under the purview of bilingual and world language education, the field of literacy research has remained largely silent on these seals. Yet, the authority these seals grant to state institutions for credentialing literacy has substantial implications for literacy research. This study analyzes 23 states that established a SoBL through legislative action. Informed by the study of seals as an ancient literacy practice, we draw on policy and visual discourse analysis to analyze state laws alongside the visual seals themselves. Incorporating theories of whiteness as property, we examine dynamics of racial, linguistic, and educational privilege to put forth a framework of biliteracy as property. Although we laud the growing popularity of the SoBL, we also caution against ceding authority to the state to assess, award, and “authenticate” biliteracy as a form of property.
Selective Immunoreactivity for WT1 Carboxy-Terminus Distinguishes Desmoplastic Small Round Cell Tumor From its Histologic Mimics
Authors: Wong Yin Ping , Buckley Kaila , Iwenofu O. Hans , Singhi Aatur , Kahwash Samir B. , Arnold Christina A. , Tan Geok Chin , Arnold Michael A.
Published: April 2022

Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric round cell sarcoma containing a characteristic EWSR1-WT1 gene fusion. In the absence of genetic data, distinguishing DSRCT from other small round cell tumors of childhood can be problematic due to overlapping histologic and immunohistochemical features. We studied the utility of immunohistochemistry with antibodies targeting both the amino-terminal and carboxy-terminal regions of the Wilms tumor-1 (WT1) protein in differentiating these groups of tumors. The study cohort included 33 cases of genetically confirmed pediatric round cell tumors (10 DSRCTs, 12 Wilms tumors, 10 Ewing sarcomas, and 1 CIC-rearranged sarcoma). Immunoreactivities and immunolocalization of both the WT1 amino-terminus and carboxy-terminus were scored and documented. All DSRCTs displayed selective reactivity for only the WT1 carboxy-terminus (10/10), while dual immunoreactivity for both the WT1 carboxy-terminus (12/12) and amino-terminus antibodies (12/12) were characteristic of Wilms tumors. CIC-rearranged sarcoma showed variable WT1 nuclear immunopositivity (1/1, 1/1) and Ewing sarcomas were consistently WT1-negative for both the WT1 amino-terminus (0/10) and carboxy-terminus (0/10). Dual WT1 amino-terminus and carboxy-terminus immunohistochemistry remains a helpful diagnostic tool in discriminating intraabdominal small round cell tumors, which serves as an adjunct to the genetic information in preventing misdiagnosis.
Carbon Emissions from Virtual and Physical Modes of Conference and Prospects for Carbon Neutrality: An Analysis From India
Authors: Periyasamy Aravind Gandhi , Singh Amarjeet , Ravindra Khaiwal
Published: April 2022

Virtual conferences are environment-friendly alternatives to physical conferences. COVID-19 pandemic has increased the use of virtual conferences. However, they are not without their share of impact on the environment. We assessed the carbon emissions (CE) of a three day national public health conference with 1474 attendees held in virtual mode and the potential CE saved compared to the physical mode. The CE of the virtual conference were estimated to be 6.44 Metric Tonne (MT) carbon dioxide (CO2) Equivalent (Eq). Potential CE that would have resulted from the physical mode of the conference were 355.85 MT CO2 Eq which is 55 times higher than the virtual mode. The live video streaming of the proceedings was the highest contributor to the virtual conference’s overall CE (81.5%). A digitally sober conference would have emitted 1.27 MT CO2 Eq, translating to a CE reduction of 80.3% from the estimated virtual conference emission. Academic conferences should strive to become carbon neutral by adopting the virtual mode of conferencing, and within that, digital sobriety should be the policy of action. Policies to motivate the adoption of virtual conferencing and digital sobriety need to be undertaken at the organizational and individual levels.
Optimizing Chemotherapy of Pancreatic Acinar Cell Carcinoma: Our Experiences and Pooled Analysis of Literature
Authors: Xu Jian-Ying , Guan Wen-Long , Lu Shi-Xun , Wei Xiao-Li , Shi Wen-Jie , Ren Chao , Li Yu-Hong , Li Sheng-Ping , Qiu Miao-Zhen , Wang Feng-Hua
Published: April 2022

Background:

Pancreatic acinar cell carcinoma (PACC) is rare, and its appropriate treatment remains unknown. We aim to explore the characteristics and optimal treatment of it.

Methods:

The data on clinicopathologic characteristics, molecular alteration, treatment, and survival of patients diagnosed with PACC at the Sun Yat-sen University Cancer Center from 2005 to 2020 were collected. The optimal treatment was explored by co-analyzing our results and published literatures.

Results:

Twenty-two PACC patients were enrolled. Eight of 17 non-metastatic patients received adjuvant chemotherapy. The patients receiving fluoropyrimidine-based regimen (n = 3) had a better median disease-free survival (mDFS) than those with gemcitabine-based regimen (n = 5) (unreached vs 27 months). Eight metastatic patients received first-line chemotherapy. Four patients received second-line chemotherapy. The objective response rate (ORR) of the fluoropyrimidine-based regimen was 85.7% (6/7), much better than that of the gemcitabine-based regimen (0/5). One patient who had responded to the first-line FOLFIRINOX (5-fluorouracil + oxaliplatin + leucovorin + irinotecan) regimen received olaparib as maintenance treatment for 5 months with good tolerance. Thirty-one published literatures, with a total of 86 cases, were included in the co-analysis. The ORR of the first-line fluoropyrimidine-based regimen (n = 47) was higher than that of gemcitabine-based regimen (n = 39) (59.6% vs 15.3%, P < .001). Eight of 11 patients treated with the FOLFIRINOX regimen achieved partial response (PR).

Conclusions:

For patients with metastasis, a fluorouracil-based regimen such as FOLFIRINOX may be preferred, and maintenance treatment of poly ADP-ribose polymerase (﻿PARP) inhibitors after effective platinum-containing treatment for breast cancer susceptibility gene (BRCA) mutation patients must be assessed.
Symptomatic Profunda Femoris Artery Aneurysm With Superficial Calf Ulcerations
Authors: Shah Meghal , Porreca Francis J. , Skripochnik Edvard
Published: April 2022

Profunda femoris artery aneurysms (PFAA) account for less than 0.5% of peripheral aneurysms. Most PFAA are secondary to trauma, iatrogenic injury, or infection, whereas the incidence of true atherosclerotic aneurysms is especially rare. These aneurysms are typically asymptomatic but can cause nerve compression, deep vein thrombosis, pain, swelling, and even rupture. We present a case of bilateral PFAA in conjunction with bilateral popliteal artery aneurysms in which the patient had rare unilateral symptoms involving calf ulcerations suggestive of geniculate emboli. We explore this unusual presentation and etiology as well as discuss the options for repair of complex PFAA.
Complete Endovascular Repair for Abdominal Aortic Aneurysm With Concomitant Aorto-Left Retroaortic Renal Vein Fistula
Authors: Cai Hong-Bo , Sun Yuan , Peng Ming-Sheng , Li Min , Wei Guang-Yuan , Yang Di , Qing Kai-Xiong
Published: April 2022

Background

Abdominal aortic aneurysm (AAA) with concomitant aorto-retroarotic left renal vein fistula (ALRVF) is an extremely rare clinical condition. With the recent development of endovascular techniques, repair of such conditions with a complete minimal invasive approach is now possible. We reported here a case of endovascular repair of AAA with concomitant ALRVF.

Case Presentation

A 62-year-old gentleman presenting with AAA and concomitant ALRVF underwent complete endovascular repair, including an endovascular aortic aneurysm repair (EVAR) with bifurcated aortic graft as well as embolization of the aneurysm sac and deployment of a covered stent in the left retroarotic renal vein to achieve sealing of the arterial-venous fistula. The patient required no blood transfusion and no ICU stay. He has been followed up closely for 4 years and has been well clinically. Aneurysm sac size has remained stable.

Conclusions

Endovascular repair can be a safe and reliable surgical alternative to treat AAA with concomitant ALRVF. But long-term follow up and more clinical data are required to verify the durability of endovascular repair for such conditions.
Initiating Ponseti management in preterm infants with clubfoot at term age
Authors: Scanlan Emily , Grima-Farrell Kate , IIhan Emre , Gibbons Paul , Gray Kelly
Published: April 2022

Purpose:

Currently, the optimal time to initiate treatment among preterm infants with clubfoot is unknown. The aim of this study was to describe treatment outcomes up to 1 year post-correction following Ponseti management in infants who were born preterm but treated at term age.

Methods:

A retrospective chart audit was conducted at a major pediatric hospital on preterm infants with clubfoot who commenced Ponseti management at term age (≥37 weeks of gestation). Data are expressed as mean values (±standard deviation) or 95% confidence intervals (95% CIs).

Results:

Twenty-six participants (40 feet) born at 32.6/40 (±3.1) weeks of gestation were identified. Thirteen (50%) were male, 14 (54%) presented bilaterally, and 7 (27%) presented with syndromic clubfoot. Ponseti management was initiated at 41.4/40 (±2.8) weeks gestation. Baseline Pirani scores were 5.2 (95%CI: 4.8–5.6) in the idiopathic group and 5.7 (95%CI: 5.0–6.4) in the syndromic group. The number of casts to correction was 5.9 (95% CI: 5.1–6.6) for those with idiopathic clubfoot and 6.1 (95%CI: 5.0–7.3) for those with syndromic clubfoot. Achilles tenotomies were required in 13 (21 feet) with idiopathic clubfoot and five (7 feet) with syndromic clubfoot. Recurrence occurred in four infants (5 feet): 4 feet required further casting and bracing, and 1 foot required additional surgery.

Conclusion:

Ponseti management at term age in preterm-born infants yields comparable 1-year outcomes to term-born infants. Further research is required to determine whether outcomes beyond 1 year of age align with growth and development demonstrated by term-born infants who are managed with the Ponseti method.

Level of evidence:

Level IV.
Vascularity of the early post-natal human distal femoral chondroepiphysis: Quantitative MRI analysis
Authors: Lin Kenneth M , Gadinsky Naomi E , Klinger Craig E , Kleeblad Laura J , Shea Kevin G , Dyke Jonathan P , Helfet David L , Rodeo Scott A , Green Daniel W , Lazaro Lionel E
Published: April 2022

Purpose:

Injury to or abnormality of developing distal femoral chondroepiphysis blood supply has been implicated in osteochondritis dissecans development. Progressive decrease in epiphyseal cartilage blood supply occurs in normal development; however, based on animal studies, it is hypothesized that there is greater decrease in regions more prone to osteochondritis dissecans lesions. We aimed to quantify differential regional perfusion of the immature distal femoral chondroepiphysis. We hypothesized there is decreased perfusion in the lateral aspect of the medial femoral condyle, the classic osteochondritis dissecans lesion location.

Methods:

Five fresh-frozen human cadaveric knees (0–6 months old) were utilized. The superficial femoral artery was cannulated proximally and contrast-enhanced magnetic resonance imaging performed using a previously reported protocol for quantifying osseous and soft tissue perfusion. Regions of interest were defined, and signal enhancement changes between pre- and post-contrast images, normalized to background muscle, were compared.

Results:

When comparing average normalized post-contrast signal enhancement of whole condyles, as well as distal, posterior, and inner (toward the notch) aspects of the medial and lateral condyles, no significant perfusion differences between condyles were found. In the medial condyle, no significant perfusion difference was found between the medial and lateral aspects.

Conclusion:

We quantified immature distal femoral chondroepiphysis regional vascularity in the early post-natal knee. In specimens aged 0–6 months, no distinct watershed region was detected. Despite possible limitations, given small sample size, as well as resolution of magnetic resonance imaging and analysis, our results suggest the hypothesized vascular abnormality predisposing osteochondritis dissecans either does not occur universally or occurs after this developmental age.
The influence of tone on proximal femoral and acetabular geometry in neuromuscular hip displacement: A comparison of cerebral palsy and spinal muscular atrophy
Authors: Ulusaloglu Armagan Can , Asma Ali , Rogers Kenneth J , Shrader Michael Wade , Graham H Kerr , Howard Jason J
Published: April 2022

Purpose:

The aim of this article was to compare longitudinal changes in hip morphology in cerebral palsy (hypertonic) and spinal muscular atrophy (hypotonic) to examine the influence of muscle tone on development of hip displacement.

Methods:

Children with spinal muscular atrophy (Types I and II) and cerebral palsy (Gross Motor Function Classification System IV and V) with hip displacement (migration percentage >30%) were included. Head shaft angle, migration percentage, and acetabular index were measured at T1 (1–2.5 years), T2 (3–5 years), and T3 (6–8 years). Analysis of variance testing and linear regression were utilized.

Results:

Sixty patients (cerebral palsy, N = 41; spinal muscular atrophy, N = 19) were included. Hip displacement occurred earlier in spinal muscular atrophy (34 months) than cerebral palsy (49 months) (p = 0.003). Head shaft angle was high and did not change between T1, T2, and T3, but significant changes in migration percentage were found (cerebral palsy: 23%, 36%, 45% (p < 0.01) and spinal muscular atrophy: 37%, 57%, 61% (p = 0.02)). Migration percentage increased by age in cerebral palsy (r = 0.41, p < 0.001), but not in spinal muscular atrophy (r = 0.18, p = 0.09). Acetabular index increased with migration percentage (cerebral palsy: r = 0.41, p < 0.001; spinal muscular atrophy: r = 0.48, p < 0.001).

Conclusion:

Persistent lateral physeal tilt by head shaft angle was found for both spinal muscular atrophy and cerebral palsy. Abnormal physeal alignment may be causally related to weakness of the hip abductor muscles rather than spasticity or muscle imbalance, resulting in coxa valga and secondary acetabular dysplasia.

Level of evidence:

III (case–control study).
Resection of calcaneonavicular coalition: Arthroscopic or open approach?
Authors: Corin Boris , Laumonerie Pierre , Zrounba Victor , Langlais Tristan , De Gauzy Jérôme Sales , Accadbled Franck
Published: April 2022

Purpose:

Calcaneonavicular coalition accounts for more than half of all tarsal coalitions. Resection of calcaneonavicular coalition by an open approach is the standard treatment. Treatment of calcaneonavicular coalition by an arthroscopic approach appears promising. The objective of our study was to compare the clinical outcomes of calcaneonavicular coalition resection by open approach versus arthroscopic approach.

Methods:

A retrospective cohort study was conducted to evaluate 127 patients who underwent a resection of calcaneonavicular coalition from 2009 to 2017. Patients were divided into two groups according to whether an arthroscopic approach or an open approach was used. Demographics, operative parameters, and clinical outcomes (foot and ankle ability measure score, subjective score, and global ankle estimation) were assessed.

Results:

Arthroscopic approach was used for 81 patients and open approach for 46 patients. Treatment with arthroscopic approach resulted in a shorter hospital stay (2.6 ± 0.6 days vs 3.0 ± 0.7; p = 0.02) and a longer operative time (24.5 ± 8.1 min vs 20.5 ± 4.2; p < 0.01) than with open approach. The foot and ankle ability measure sports subscale scored significantly higher in the arthroscopic approach group (90.9 vs 77.3; p = 0.003). Revision rate was significantly higher in the arthroscopic approach group (12 (15%)) versus the open approach group (1 (2%)) ( p = 0.024). Persistent symptoms ( n = 12) were the main reason for revision.

Conclusions:

Arthroscopic treatment of calcaneonavicular coalition is associated with a higher revision rate than the open approach.

Level of evidence:

Level III—retrospective comparative study.
Anxiety surrounding supracondylar humerus pin removal in children
Authors: Sanborn Ryan M , Bauer Andrea S , Miller Patricia E , Kramer Dennis E , May Collin J , Vuillermin Carley B , Yen Yi-Meng
Published: April 2022

Purpose:

The purpose of this study was to quantify the anxiety experienced by patients undergoing pin removal in clinic following closed reduction and percutaneous pinning for supracondylar humerus fractures.

Methods:

We prospectively enrolled 53 patients (3–8 years) treated for supracondylar humerus fracture with closed reduction and percutaneous pinning between July 2018 and February 2020. Demographic and injury data were recorded. Heart rate and the Face, Legs, Activity, Cry, and Consolability scale were measured immediately before pin removal and after pin removal, and crossover control values were obtained at the subsequent follow-up clinic visit.

Results:

All patients experienced anxiety immediately prior to pin removal (95% confidence interval, 94%–100%) with a median Face, Legs, Activity, Cry, and Consolability score of 7 (interquartile range, 6–8). In addition, 98% of subjects experienced an elevated heart rate (95% confidence interval, 88%–100%). Patients experienced a median 73% reduction in Face, Legs, Activity, Cry, and Consolability score and mean 21% reduction in heart rate from prior to pin removal to after pin removal ( p < 0.001). All 45 patients who completed their follow-up visit had a control Face, Legs, Activity, Cry, and Consolability score of 0 and a mean control heart rate of 89.7 bpm. Twenty-five of these 45 subjects (56%) had an elevated control heart rate for their age and sex. Mean heart rate prior to pin removal was 36% higher than control heart rate. There were no sex differences detected in Face, Legs, Activity, Cry, and Consolability scores or heart rate.

Conclusions:

Pediatric patients experience high levels of anxiety when undergoing pin removal following closed reduction and percutaneous pinning for supracondylar humerus fractures. This is an area of clinical practice where intervention may be warranted to decrease patient anxiety.

Level of evidence:

II
COVID-19 pandemic restrictions unmasks dangers of frequent injury mechanisms for common surgically treated pediatric fractures
Authors: Gornick Bryn R , Mostamand Mashgan , Thomas Evelyn S , Weber Matthew , Schlechter John A
Published: April 2022

Purpose:

This study examined the volume and characteristics of common surgically treated fractures in children during the COVID-19 pandemic. The worldwide spread of COVID-19 affected the society in numerous ways. Social distancing led to changes in the types of activities performed by individuals, including children. Physicians saw a shift in orthopedic trauma volume and distribution. We predicted that with the change in activities children participated in, the number or type of injuries sustained would change as well.

Methods:

A retrospective review was performed of children who sustained a surgically treated fracture of the forearm, supracondylar humerus, femur, or any open fracture during the COVID-19 pandemic compared to the previous 2 years (pre-pandemic). Patient demographics, insurance status, and mechanism of injury were recorded. Statistical analysis was performed.

Results:

Review of the medical records identified 791 children. The number of fractures decreased from an average of 295 per year pre-pandemic to 201 during the pandemic (p = 0.09). During the pandemic, there was a decrease in injuries resulting from a fall from the monkey bars for supracondylar humerus (21.2% to 8.2%, p < 0.01) and for forearm fractures (15.5% to 4.3%, p = 0.04). In contrast, the frequencies of falls from a skateboard, hoverboard, scooter, or bicycle and falls from household furniture increased during the pandemic.

Conclusion:

The observed decrease in monkey bar–related injuries provides further evidence as to the dangers of this piece of playground equipment in contributing to upper-extremity fractures in children.

Level of evidence:

Level III: Prognostic and Epidemiological.
A Smartphone-Based Application to Assist Insulin Titration in Patients Undergoing Basal Insulin-Supported Oral Antidiabetic Treatment
Authors: Tews Dietrich , Gouveri Evanthia , Simon Jörg , Marck Cornelia
Published: April 2022

Introduction:

INSULIA is an insulin-titration app developed for patients with type 2 diabetes treated with basal insulin as part of a basal insulin-supported oral therapy (BOT). The app uses patient-logged fasting blood glucose (FBG) values and a titration plan defined by the treating physician to provide basal insulin dosing recommendations. Physicians use the web portal to monitor their patients’ therapy progress and, if necessary, adjust therapy. The aim of this study was to assess the app, specifically its features, handling and impact on diabetes treatment and self-management in Germany.

Methods:

This German retrospective pilot study included physicians (diabetologists, general practitioners, and internists) and patients with type 2 diabetes who either receive or start BOT using the app. Both groups completed group-specific questionnaires between December 2018 and June 2019.

Results:

Overall, 10 physicians and 34 patients with type 2 diabetes completed their respective questionnaires. Physicians perceived their app-using patients to be more involved and more confident in managing their insulin therapy than patients not using the app. The majority of patients considered the app as a tool that assists with safer insulin treatment. The physicians perceived that due to the app use, FBG and HbA1c target values were achieved more often than patients not using the app and the number and severity of hypoglycemic episodes was reduced.

Conclusion:

The titration app seems to have a positive impact on BOT patients’ FBG and HbA1c target achievement and was highly appreciated by both physicians and patients alike.
New or Recurrent Knee Injury, Physical Activity, and Osteoarthritis Beliefs in a Cohort of Female Athletes 2 to 3 Years After ACL Reconstruction and Matched Healthy Peers
Authors: Ezzat Allison M. , Brussoni Mariana , Mâsse Louise C. , Barton Christian J. , Emery Carolyn A.
Published: May 2022

Background:

At 2 to 3 years after anterior cruciate ligament reconstruction (ACLR), the relationship between known modifiable osteoarthritis (OA) risk factors and recurrent knee injury is unknown. This study aimed to determine the odds of new or recurrent traumatic knee injury in a cohort of young female athletes with ACLR 2 to 3 years postsurgery compared with healthy control participants. Secondary objectives were to explore the relationships of moderate and vigorous physical activity (MVPA) and body mass index (BMI) with knee injury, and to document self-reported MVPA satisfaction and beliefs about OA.

Study Design:

Prospective cohort.

Level of Evidence:

Level 2.

Methods:

A total of 51 female athletes with unilateral ACLR 1 to 2 years previously and 51 age and sport-matched control participants underwent assessment of MVPA (GT3X accelerometers) and BMI. One year later, participants self-reported knee injuries. Bivariable conditional logistic regression explored the association between knee injury, MVPA, and BMI in each group (injury/control).

Results:

At 1-year follow-up (n = 101), 19.6% of the injured cohort and 6.0% of control participants sustained a new or recurrent knee injury. The odds of knee injury for the injury group increased 7-fold over controls [odds ratio (OR) = 7.00 (95% CI = 0.86, 56.90)], although this was not statistically significant. The OR for MVPA was 0.98 (95% CI = 0.93, 1.03) and BMI was OR = 1.24 (95% CI = 0.85, 1.82). Half (56.0%) of injury participants and 66% of controls were satisfied with their MVPA; 81.6% of injury participants believed they had increased knee OA risk compared with someone who had never had a knee injury.

Conclusion:

In the 2 to 3 years after ACLR, 1 in 5 young female athletes had a new or recurrent knee injury. Based on the point estimate, injured participants were more likely to suffer a traumatic knee injury than matched control participants. MVPA and BMI were not associated with increased odds of knee injury.

Clinical Relevance:

Clinicians should be encouraged to have in-depth conversations with female athletes with previous ACLR regarding enjoyable and sustainable MVPA participation to promote long-term joint health.
Extracorporealization of the Mandibular Condyle: Effects on Viability and Function
Authors: Emmerling Max R. , LaVigne Meghan , Warburton Gary , Caccamese John F. , Ord Robert A.
Published: May 2022

Study Design

For certain condylar fractures, extracorporealization of the condylar segment may be performed via extra-oral vertical ramus osteotomy (EVRO) to facilitate reduction and fixation. This approach can similarly be used for condyle-sparing resection of osteochondromas of the condyle. Due to controversy regarding long-term health of the condyle after extracorporealization, we conducted a retrospective analysis of surgical outcomes.

Objective

For certain condylar fractures, extracorporealization of the condylar segment may be performed via extra-oral vertical ramus osteotomy (EVRO) to facilitate reduction and fixation. This approach can similarly be used for condyle-sparing resection of osteochondromas of the condyle. Due to controversy regarding long-term health of the condyle after extracorporealization, we investigated the viability of this technique through a retrospective analysis of outcomes.

Methods

Twenty-six patients were treated using EVRO with extracorporealization of the condyle for both condylar fractures (18 patients) and osteochondroma (8 patients). Of the 18 trauma patients, 4 were excluded due to limited follow-up. Clinical outcomes were measured, including occlusion, maximum interincisal opening (MIO), facial asymmetry, incidence of infection, and temporomandibular joint (TMJ) pain. Radiographic signs of condylar resorption were investigated, quantified, and categorized using panoramic imaging.

Results

Average follow-up was 15.9 months. Average maximum interincisal opening was 36.8 mm. Four patients demonstrated mild resorption and one patient demonstrated moderate resorption. Two cases of malocclusion were attributed to failed repairs of other concurrent facial fractures. Three patients reported TMJ pain.

Conclusions

Extracorporealization of the condylar segment with EVRO to facilitate open treatment of condylar fractures is a viable treatment option when more conventional approaches prove unsuccessful.
Late hemorrhagic transformation of brain lesions in case with methanol intoxication
Authors: Yaşgüçlükal Miray A , Eyüpoğlu Selin , Kaya Bahar
Published: April 2022

Methanol intoxication can be occurred as accidental or suicidal ingestion or intentional ingestion through abuse. Formic acid is the primary toxic metabolite which causes high anion gap metabolic acidosis and end-organ damage in the human body. Here we presented a 46-year-old man who loss of consciousness on the 23rd day of hospitalization and his cranial computed tomography revealed bilateral subcortical hemorrhages. This case indicates us an example of late appearance of hemorrhagic transformation in methanol intoxication.
The magnitude of undiagnosed hypertension and associated factors among HIV-positive patients attending antiretroviral therapy clinics of Butajira General Hospital, Gurage Zone, Southern Ethiopia
Authors: Zewudie Bitew Tefera , Geze Tenaw Shegaw , Solomon Mamo , Mesfin Yibeltal , Abebe Haimanot , Mekonnen Zebene , Tesfa Shegaw , Chekole Temere Bogale , Aynalem Mewahegn Agerie , lankrew Tadele , Sewale Yihenew
Published: April 2022

Objectives:

The study aimed to assess the magnitude of undiagnosed hypertension, and its associated factors among adult HIV-positive patients receiving antiretroviral therapy at Butajira General Hospital, southern Ethiopia.

Methods:

We applied an institutional-based cross-sectional study design at Butajira General Hospital from 1 May to 1 July 2021. We used a systematic random sampling technique to select the total number of participants. A structured interviewer-administered questionnaire was applied to collect the data (sociodemographic characteristics, clinical-related factors, and lifestyle-related factors from the study participants. Data were entered using Epi-data version 3.1 and analyzed by statistical package for social science version 25. We applied a multivariable logistic regression analysis model to identify variables significantly associated with hypertension.

Results:

The study comprised 388 participants with 39 years (10.6 SD) as the mean age of the participants. Of the total participants, 235 (60.6%) were female. In this study the magnitude of undiagnosed hypertension among HIV-positive patients was 18.8% (95% CI: 14.7%–23.2%). Having comorbidity of diabetes mellitus (adjusted odds ratio = 5.29, 95% CI: 2.154, 12.99), habit of alcohol drinking (adjusted odds ratio = 2.909, 95% CI: 1.306, 6.481), duration of antiretroviral therapy ⩾ 5 years (adjusted odds ratio = 3.087, 95% CI: 1.558, 6.115), and age ⩾ 40 years (adjusted odds ratio = 2.642, 95% CI: 1.450, 4.813) were factors significantly associated with undiagnosed hypertension.

Conclusions and recommendations:

The magnitude of undiagnosed hypertension among HIV-positive patients attending the antiretroviral therapy clinic of Butajira General Hospital is high. The findings of this study implied that HIV-positive patients attending antiretroviral therapy clinics should be monitored routinely for hypertension; especially participants aged ⩾40 years, highly active antiretroviral therapy duration ⩾5 years, having diabetes mellitus comorbidity need more attention. Primary healthcare integration is also vital to enhance the health of HIV-positive patients on antiretroviral therapy.
Sexual and urinary function after organ sparing surgery for penile cancer: A questionnaire study of consecutive patients over a 3-year period in a single region
Authors: Zimmermann Eleanor F , Embury-Young Ysabelle , Dickerson David , Manjunath Aditya
Published: April 2022

Objective:

The European Association of Urology recommends organ-sparing surgery (OSS) for localised penile cancer. We aimed to assess the impact of OSS including glans reconstruction on erectile, sexual and urinary function.

Method:

Local ethics approval was obtained. Patients coded for glans resurfacing, glansectomy and partial penectomy from 2015 to 2018 were identified across two trusts. Background characteristics, histology, staging and follow-up were recorded. Two questionnaires were used to assess function: a custom questionnaire on patient reported outcomes and the International Index of Erectile Function (IIEF) Questionnaire. Anonymised questionnaires were sent to each patient with prepaid return envelopes included.

Results:

A total of 28/64 (44%) questionnaires were returned complete. The mean age of participants was 71(35–93) and body mass index (BMI) 28(20–38). There was 1 glans resurfacing, 1 circumcision and wide local excision, 8 glansectomy and 18 partial-penectomy patients (of which 4 and 13 declined reconstruction, respectively). Sexual satisfaction (SS) and erectile function (EF) declined postoperatively while sexual desire was preserved. Subjective glans sensitivity reduced independent of technique. Glans reconstruction reduced the impact on IIEF in glansectomy (13.5 versus 25.3, p < 0.05) but not partial-penectomy (13.4 versus 13.8). SS was worse in partial-penectomy patients undergoing glans reconstruction on patient-reported outcome measures (PROM) (SS change: −4.0/10 with reconstruction versus −0.9/10 without, p < 0.05). Urinary symptoms appear limited to spraying and change of flow of urine, with some patients reporting the need to pass urine sitting down.

Conclusion:

Sexual and erectile function is impaired post-OSS in penile cancer while sexual desire is preserved. Simultaneous glans reconstruction appears to minimise this impact in glansectomy patients when assessed by IIEF. A validated PROM questionnaire could improve preoperative counselling, and guide postoperative sexual recovery.
Understanding Political Polarization Based on User Activity: A Case Study in Korean Political YouTube Channels
Authors: Tran Giang T. C. , Nguyen Luong Vuong , Jung Jason J. , Han Jeonghun
Published: April 2022

This study proposes a novel approach for measuring political polarization using a user-activity-based model. By exploiting data from comments, user activity in this study is defined based on features such as coverage, duration, and enthusiasm. To determine these features, we collect information on the activities of users from South Korean YouTube channels. Notably, the collected data of the model contains approximately 11 M comments from more than 600 K users based on 37 K videos of 77 YouTube channels. To handle the big data collection, we deploy a web-based platform called TubePlunger to collect video information (e.g., comments, replies, etc.) automatically from YouTube channels. The output of the model reveals that the users are strongly polarized because the number of neutral users is very small (approximately 8% of the total). We then applied this model to the other channels in the testing dataset to define polarization with a bias percentage and to visualize the user activity distribution. The experimental results show that there are 30 fully polarized YouTube channels (16 left-wing channels and 14 right-wing channels) with a measured bias ratio higher than 70%. Our method of analyzing social network data based on user activity provides the foundation for polarization analysis that can be applied to fields other than politics.
Significance and Challenges of Formative Ipsative Assessment in Inquiry Learning: A Case Study of Writing Activities in a “Contemporary Society” Course in a Japanese High School
Authors: Nishizuka Kohei
Published: April 2022

The theory of formative assessment highlights the importance of ipsative assessment, which uses internally generated criteria and goals to compare students’ performance with their past performance. This study designed a formative ipsative assessment practice as part of inquiry learning in high school and clarified its significance and challenges. The results of three rounds of academic writing for high school freshmen showed that the practice gradually improved students’ overall writing skills; thus, qualitative improvement and transformation in performance-centered learning were expected. In high schools, where a single teacher is responsible for many students and is constrained by external standards such as university entrance exams, one strategy is to align learning and assessment by developing abstract higher-order criteria and then developing them into concrete lower-order criteria appropriate for each student. This paper presents five challenges and these solutions.
Academic Hatred: Focusing on the Influence of a Supportive Classroom Climate
Authors: Lee Minyoung , Lee Mi Kyoung , Yaung Huk , Lee Taerim , Lee Sang Min
Published: April 2022

This study aimed to examine the effects of interpersonal factors (i.e., teacher and peers) on academic hatred using the hierarchical linear model analysis. The data were collected from 1,015 senior high school students from 43 classrooms (57.3% female) in South Korea. The results showed significant effects of teachers’ academic pressure, autonomy support, and peer support on academic hatred at both the individual and classroom levels. Interestingly, teachers’ academic pressure showed different effects on academic hatred at the individual and classroom levels: a negative effect at the individual level and a positive one at the classroom level. At the classroom level, peer support did not significantly influence academic hatred, while at the individual level, peer support negatively affected academic hatred by interacting with teachers’ autonomy support. This paper discusses the practical implications for preventing academic hatred in the classroom.