bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of electrical conductivity, pH and refractive index as physico-chemical parameters for quality control of Aveloz homeopathic solutions
Authors: Silva Isabella Oliveira , Cardoso Rafael Harduim , Zacharias Carlos Renato , Garcia Sheila , Holandino Carla
Published: December 2021

Euphorbia tirucalli Lineu (Aveloz) belongs to the family Euphorbiaceae and is used in the treatment of cancer and warts. Some studies have reported that phorbol esters are the active principles responsible for the antitumor activity of Aveloz. The production of these molecules occurs in greater quantity in May, during the morning. This study aimed to evaluate whether the physico-chemical parameters of Aveloz homeopathic aqueous solutions such as pH, electrical conductivity and refractive index change due to storage time. Such parameters were measured regularly for 180 days. All solutions were prepared according to the method of grinding with lactose and subsequent dissolution in aqueous medium, as described in the Brazilian Homeopathic Pharmacopoeia, using as starting point the Aveloz latex collected in May. Homeopathic aqueous solutions containing only lactose were also prepared and evaluated as a control group. The potencies that were analyzed for electrical conductivity, pH and refractive index were: 4cH, 7cH, 9cH, 12cH, 14cH, 15cH, 29cH, 30cH. As a result, we found out that there was only statistical difference (p=0.035) in electrical conductivity between the homeopathic solutions containing Aveloz and the homeopathic solutions without Aveloz, when 15cH potency was compared. We also observed that the electrical conductivity increased with the aging of the solutions but is not directly related to the pH or the refractive index of the solutions, indicating that the aging process may alter the electrical conductivity of the homeopathic medicines. The presence of gas inside the glass that stores these solutions may affect the electrical conductivity measurements. Finally, no statistically significant difference was observed (p> 0.05) in the pH and refractive index.
Therapeutic possibilities of coriaria myrtifolia L. in high dilutions
Authors: Cheng Marcia Amoedo , Freitas Francisco JosÃƒÆ’Ã‚Â© de
Published: December 2021

Background: Homeopathy literature shows references about Coriaria myrtifolia L. at some important Homeopathic Materia Medica: Allen,TF [1], Voisin H [2] and Vijnovsky B [3]. Those reports are unsatisfactory to fulfill a contemporary standardized study basis on: origin and description, preparation, medicine general action, sensations and modalities; demanding a broader investigation.

Aims: Identify therapeutic possibilities on Coriaria myrtifolia L. from ratifying and broadening the homeopathic materia medica knowledge.

Methodology: Literature review on botanical, biochemical and pharmacological data [4-12]. The use of plant in various fields since XVIII century and analyzes of clinical-toxicological reports described in medical reviews published.

Results: Coriaria myrtifolia L. is a toxic shrub, growing wild in western Mediterranean region. The entire plant contains a sesquiterpene-lactone called coriamyrtin, a potent convulsivant neurotoxin. Clinical manifestations of acute intoxication includes: Central Nervous System ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ generalized tonic-clonic seizures, recurrent, which may evolve to status epilepticus, coma, apnea and death. Respiratory Tract ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ respiratory depression due to anoxia, respiratory arrhythmia alternating with apnea, respiratory muscles tetanization evolving to respiratory arrest. Cardiovascular System ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ central excitatory action which may initially promote increased blood pressure followed by heart failure, as a result of the seizures, due to anoxia and acidosis, leading to cardiac arrest. Gastrointestinal Tract ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ nausea, vomiting and stomach pains that precede seizures; since there is no evidence of toxin direct action on mucosa, those symptoms may relate to Central Nervous System action (attributed to impairment of cranial nerve VIII). Knowledge of these aspects gave us possibility to build a Coriaria myrtifolia L. materia medica with broader clinical indications.

Conclusion: Coriaria myrtifolia L. is a valuable source to be used in high dilutions as medicine indicated for epileptic syndromes treatment, characterized by tonic-clonic seizures, mainly presenting a malignant tendency, with recurrent seizures, which may evolve to status epilepticus and potential mortality risk. Among the clinical indications proposed stand out etiologies of great incidence at emergency rooms such as metabolic or vascular primary disorders, or resulting from systemic diseases (diabetes, hepatopathy, nephropathy), encephalitis and meningitis with or without Acquired Immunodeficiency Syndrome, withdrawal syndrome from alcohol or drugs, exogenous poisoning, poisoning or overdose of alcohol or drugs, traumatic brain injury and intracranial expanding lesions.
Dance and Science: an analysis of the creative process behind "Transitions", a show by Contemporary Dance Company of UFRJ
Authors: Alves de Lima AndrÃƒÆ’Ã‚Â© Meyer , Pinto Almeida Danielle Vianna Menezes , Vieyra Adalberto Ramon
Published: December 2021

This study proposes an esthetic reflection on the influence of the biological sciences on dance as a variety of contemporary art. The relationship between science and art in this study is grounded on FranÃƒÆ’Ã‚Â§ois DagognetÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s hyperphenomenology, particularly his representation of the major role played by the image-symbol as essential base of present-day scientific activity [1]. Contemporary dance creators and companies such as Wayne Mac Gregor, Phylobolus Dance Company and Liz Lerman Dance Exchange are analyzed, in order to highlight how some biosciences themes are explored as creative potentials in their dance performances [2,3,4]. We aim at relating biological shapes and patterns existing in the cellular and molecular universe with the fundamentals of dance described by Helenita Sá Earp. EarpÃƒÂ¢Ã¢â€šÂ¬Ã¢â€žÂ¢s conception posits dance as wide-scoped knowledge, including a ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œscience of danceÃƒÂ¢Ã¢â€šÂ¬Ã‚Â where intuition works as basic foundation and its epistemology is made of an open type of knowledge named ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œdance parametersÃƒÂ¢Ã¢â€šÂ¬Ã‚Â, namely motion, space, shape, dynamics and time. These parameters allow establishing access points for multiple connections within the realm of dance. This approach tends to generate a kind of access to body actions stimulating interdisciplinarity between several areas of knowledge [4]. As study-case, we focus methodologically on the processes of esthetic creation involved in the production of a multimedia show entitled ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œTransitionsÃƒÂ¢Ã¢â€šÂ¬Ã‚Â by appealing to biochemical notions, especially some features of cytology and cellular morphology, cell proliferation and processes of cellular transportation [5].
Mice behavioural models with pooled data analysis of Gelsemium studies and new findings about Ignatia and Aconitum
Authors: Bellavite Paolo , Magnani Paolo , Marzotto Marta , Cristofoletti Mirko , Zanolin Mariaelisabetta , Conforti Anita
Published: December 2021

Objective: We investigated the effects of three different homeopathic medicines in several dilutions/dynamizations on mice, using validated models which explore anxiety-like and emotional symptoms. Two complete series of investigations were performed in order to assess the activity of Gelsemium sempervirens; furthermore, we investigated Ignatia amara and Aconitum napellus in the same model systems.

Methods: Mice of CD1 strain were randomized in different cages (minimum 8 mice per treated group in each experiment) and treatment solutions were coded in such a way that all protocols were carried out fully in blind. The indicated compounds at various centesimal dilutions/dynamizations, a control solution (the solvent vehicle of drugs, which was succussed before administration) or the reference drugs diazepam (1 mg/kg body weight) or buspirone (5 mg/kg body weight) diluted in the same succussed solvent were delivered intraperitoneally (0.3 ml/mice) for 9 days. A series of changes of animal behavior were assessed by the Light-Dark (LD) choice test and the Open-Field (OF) exploration test. Two series of studies with little technical differences, exploiting a total of 14 separate experiments, were carried out with Gelsemium, five complete experiments with Ignatia and four complete experiments with Aconitum.

Results: In both series of experiments Gelsemium showed anxiolytic-like effects using both OF test (permanence and movement in centre area of field) and LD test (time spent in lit area and number of light-dark transitions). However, due to high variability of animal responses and possibly to some minor differences in protocols, those effects reached the threshold of statistical significance only in OF in the first series and only in LD in the second series. Cumulative analysis of the two series demonstrated a highly significant (p
Good winds are expected!
Authors: Zacharias Carlos Renato
Published: December 2021

Probably by cultural and historical reasons, Western Europe occupied the center of homeopathy research stage. It was in Western Europe that Hahnemann initially established the grounds of homeopathy, and also were Western European the researchers who have been trying to characterize the scientific bases behind high dilutions biological action ever since. Europe witnessed all phases of homeopathy development, its growth and also its decline, its time of glory as well as its many crises. Ideological divergences ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ sometimes grounded on irresponsible attitudes by homeopaths themselves, sometimes arising from skeptics pride and prejudice ÃƒÂ¢Ã¢â€šÂ¬Ã¢â‚¬Å“ gave rise to political and social movements against homeopathy. In spite of this, clinical and experimental evidences kept homeopathy alive as an important therapeutic option able to reunite low cost and efficacy provided its conceptual basis and limitations are observed.

...

More than ever, HD research appears as an emergent and highly active field! And much work still needs to be done. The academic geography of HD research is changing. It is not a matter of replacing old by new research centers. As a fact, HD research is expanding its boundaries, its scientific community has started sharing responsibility and joining efforts. As any other scientific field, also HD research is building a critical mass, which is a sine qua non requirement for research to attain the quality demanded by contemporary science.

New winds are blowing and they will surprise those little prepared or unexpecting.
Mapping Autistic Wayfinding in Urban Environments
Authors: Castellanos Irma , Hruby Florian
Published: December 2021

Abstract. Needs and preferences in wayfinding tasks of people with autism spectrum disorders (ASD) have been a topic of ongoing discussion in the scientific literature over the last decades. While different tasks have revealed both autistic strengths (e.g., encoding and recall of route information) and weaknesses (e.g., understanding allocentric representations), ASD spatial behaviour is not fully understood yet. In this paper we focus on spatial uncertainty, which is the discrepancy between a-priori expectation and in-situ experience and thus a constant factor in ASD wayfinding tasks. As a matter of course, spatial uncertainty is inevitable, always resulting from a dynamic interaction of situational qualities (e.g., noise or smell). Nevertheless, mapping uncertainty and the underlying spatial patterns in an organized way might help users from the ASD spectrum to better prepare for the different levels of expectable uncertainty in route. We propose a framework of conceptualizing, measuring, and mapping spatial uncertainty from an autistic viewpoint. The discussion of this framework is based on a qualitative analysis of the spatial behaviour of B, a five-year-old child with ASD and nonverbal communication, in an urban environment. We compare the level of spatial uncertainty of the routes developed by B against the routes indicated by ourselves.
IGiS FOR MANAGING CITIES SMARTLY – URBAN GEOINFORMATICS
Authors: Shah P.
Published: December 2021

Abstract. A city is a geographic entity and should be efficiently analysed and optimised through the use of geo-spatial technology. The certification for a city to be ‘Smart’ is measured on the basis of the liveable index, adequacy of water supply, assured supply of electricity, proper sanitation and solid waste management, efficient urban mobility, public transport, affordable housing, robust information technology connectivity, transparent and good governance, safety and security of citizens, modernised health and education infrastructure and citizen participation which will lead to sustainable development. Smart Cities require a perfect balancing of modernisation of city infrastructure and leveraging technology. Smart cities require Geo-smart mapping and visualization capabilities with applications for protecting groundwater resources, locating schools and health centres, locating garbage dumps and toilets, designing bus routes. The indigenously developed integrated platform of GIS, Image Processing, Photogrammetry and CAD, called IGiS has been leveraged by Scanpoint Geomatics Limited, Ahmedabad (SGL), India for implementing the Enterprise GIS for 7 smart cities in India. A centralised geo spatial database with a standard data model compliant set of maps/layers has been created for each city. The spatial layers are derived from 30cm resolution satellite data. Point data (locational information) is generated using DGPS surveys. The city assets are geographically mapped at a scale of 1:2000 and organised in a spatial database. Inputs required for operations and maintenance of every utility/facility are geo tagged and stored in the database. Web & Mobile GIS applications & Citizen portal are developed using the indigenous platform. Integration with other e-governance applications and spatial layer requirements of the Integrated Command and Control Centre are supported through RestAPI & OGC compliant web services. SGL’s Mobile GIS framework named Qpad comes handy for spatial data verification. IoT devices are used to gain insights for real-time handling of critical situations or emergencies. Having laid the foundation for driving smart cities in terms of the spatial database at a scale of 1:2000, the stage is set to look forward to the results. Plugging revenue leakages, better traffic management, information at a click during peak of the Corona pandemic, effective usage of open spaces and barren areas, planning the utility requirements by the corporation to accommodate for the urban explosion is the kind of harvest that is anticipated with abated breath. This paper demonstrates the suitability and capability of the indigenously developed common platform for image processing and GIS (IGiS Enterprise Suite) in building Smart City Applications and quantifying the results.
ASSESSING URBAN FOREST CANOPY COVER IN GREAT PLAIN CONSERVATION AREA (DÜZCE CITY, TURKEY) BETWEEN 1984 AND 2015
Authors: Uçar Z. , Eker R. , Aydin A.
Published: December 2021

Abstract. Urban trees and forests are essential components of the urban environment. They can provide numerous ecosystem services and goods, including but not limited to recreational opportunities and aesthetic values, removal of air pollutants, improving air and water quality, providing shade and cooling effect, reducing energy use, and storage of atmospheric CO2. However, urban trees and forests have been in danger of being lost by dense housing resulting from population growth in the cities since the 1950s, leading to increased local temperature, pollution level, and flooding risk. Thus, determining the status of urban trees and forests is necessary for comprehensive understanding and quantifying the ecosystem services and goods. Tree canopy cover is a relatively quick, easy to obtain, and cost-effective urban forestry metric broadly used to estimate ecosystem services and goods of the urban forest. This study aimed to determine urban forest canopy cover areas and monitor the changes between 1984–2015 for the Great Plain Conservation area (GPCA) that has been declared as a conservation Area (GPCA) in 2017, located on the border of Düzce City (Western Black Sea Region of Turkey). Although GPCA is a conservation area for agricultural purposes, it consists of the city center with 250,000 population and most settlement areas. A random point sampling approach, the most common sampling approach, was applied to estimate urban tree canopy cover and their changes over time from historical aerial imageries. Tree canopy cover ranged from 16.0% to 27.4% within the study period. The changes in urban canopy cover between 1984–1999 and 1999–2015 were statistically significant, while there was no statistical difference compared to the changes in tree canopy cover between 1984–2015. The result of the study suggested that an accurate estimate of urban tree canopy cover and monitoring long-term canopy cover changes are essential to determine the current situation and the trends for the future. It will help city planners and policymakers in decision-making processes for the future of urban areas.
Gender and Urban Informal Sector Employment: An Analysis from Southern Punjab, Pakistan
Authors: Gillani Durdana Qaiser , Shah Hassan Shakeel , Bashir Hafiza Nadia
Published: December 2021

The decision to work in the labor market commonly depends on a decision by the participants between two options: to work or not to work. However, the priorities are different. Some females prefer to involve themselves in some economic activities (paid work) at home and some market activities. This research investigates the factors that motivate males and females to engage in informal employment. The data has been used collected from a household survey. This survey is made from three divisions of Southern Punjab, where the majority of the population resides. The survey is premeditated to gather some information of the households regarding demographic, social, and economic factors. The present study investigates the factors of employment by using the logit model. Findings show that low educated, married and aged people are working in the informal sector. Formally trained workers and workers of highly educated parents are switching to the formal sector. Those having assets are working in the informal sector. Those female participants having adults are participating in the informal sector. Based on study results, it is suggested that government must provide more employment opportunities in urban areas of Southern Punjab.
Stock Market Reaction towards Terrorism: An Evidence Based on Seasonal Variation in Pakistan
Authors: Abbas Jauhar , Mirza Hammad Hassan , Hussain Haroon , Hussain Rana Yassir , Saad Muhammad , Akhtar Masud
Published: December 2021

This study examined whether the impact of terrorism events on the stock market varies based on seasonal anomalies (i.e., spring, summer, autumn, and winter). For this purpose, this study selected and obtained the data of 344 terrorist events that occurred in Pakistan and daily closing index price data of KSE 100 for the period ranging from 2008 to 2017. To fulfil the study's objective, this study applies the event day analysis by using five days window (-2, -1, 0, +1, +2) by employing the Exponential Generalized Autoregressive Conditional Heteroskedasticity (GARCH) model. The findings of this study shows that there is no significant impact of terrorist events on stock returns in Pakistan on pre-event day 2 and event day.  However, terrorism events have a significant positive impact on stock returns on pre-event day 1 and post-event day 1. On the contrary, stock returns on post-event day 2 showed a significant positive but in negative direction. In addition, this study also found that stock market returns vary significantly based on seasonal anomalies. However, it is also revealed that the impact of terrorism (event day) on the stock market’s returns does not significantly vary during all seasons in Pakistan except autumn and similarly, the impact of terrorism (post-event day 1) on the stock market’s returns does not significantly vary during said weather seasons in Pakistan. Furthermore, the positive impact of terrorism (during post-event day 2) upon the stock market’s returns significantly differs during weather seasons of spring, summer, and autumn in Pakistan. As per the results, this study suggests that the investor should invest on event day and resell/ withdraw his investment on post-event day 1 in order to earn higher profit.
Perception of Higher Secondary Schools Teachers towards Academic Performance of Students
Authors: Afzal Sana , Qayyum Faiza
Published: December 2021

The world is becoming more and more competitive and for the performance and personal progress is the key factor. A study was designed to know teachers' perceptions regarding students' performance at the higher secondary school level. All the higher secondary school students (male and female) were the population of the study. The higher secondary schools of district Toba Tek Singh were considered for the target population. The 80 teachers (40 male and 40 female) were chosen as a study sample proportionate from the 17 higher secondary schools. The collected data were statistically analyzed using descriptive statistics frequency and percentages with Statistical Package for Social Sciences (SPSS) software. The demographic characteristic of respondents shows that the vast majority of teachers have a graduate degree, and half of the teachers belong to the 25-50 age category and have up to 10 years experience, respectively. The teachers’ response indicated that students of higher secondary schools have confidence in asking and answering questions.
Impact of Public Debt on Health and Education in SAARC Countries
Authors: Tasleem Hassan
Published: December 2021

The present study has done to investigate the impact of external debt servicing on health and education spending for the panel of selected SAARC countries (Bangladesh, India, Pakistan and Sri Lanka) are basically developing countries of Asia. This study uses two models of education spending and the other is for health spending by using the data set for 1990-2016 and estimations are carried out by using fixed effect model. Beside other explanatory variables debt servicing is the most important determinant of education spending and health spending and confirm the literature view that high external debt leads to increase in debt servicing liabilities and government do repayment of debt servicing by cutting its expenditure especially on health and education spending as it is easy for government to cut down the social sector spending rather than other sector spending. Other variable Tax revenue and Gross Capital Formation also effect the health and education spending but debt servicing liability effect more. It is best for SAARC countries to use and organize their own resources efficiently and less dependence on external debt and on foreign borrowing and give high attention to education and health spending.
The right of the defense to request an explanation of the accusation during the criminal investigation phase
Authors:   National Institute of Justice, Republic of Moldova, Vizdoaga Tatiana , Esanu Adriana ,   National Institute of Justice, Republic of Moldova
Published: December 2021

Pursuant to Article 66 paragraph (2) point 1) of the Code of Criminal Procedure, the accused has the right to know for what deed he is accused […], i.e. to be informed on the nature and cause of the accusation brought against him. If the person is not properly informed about the accusation, he is deprived of the right to ensure the possibility of preparing and exercising his defense, being seriously affected by the principles of a fair trial, guaranteed by Article 6 of the European Convention for the Protection of Human Rights and Fundamental Freedoms. Although the principle governing the exercise of rights by the accused in criminal proceedings guarantees the use of any means and procedures of defense, except those expressly prohibited by law, some prosecutors are reluctant to defenders’ requests to explain the accusation in criminal proceedings, context in which, in most cases, either declares them inadmissible or considers them unfounded. Such an approach does not reconcile the right to a fair trial; or, the clarity of what is set out in the indictment is also linked to the right of the accused to defend himself – as an indispensable element of the protection of the person against arbitrariness. Therefore, in this study, the authors will come up with pertinent arguments to annihilate the vicious practice of prosecutors to disregard the importance of predictability of the accusation in order to ensure the right to defense, as well as avoiding the conviction of the Republic of Moldova by the European Court for European Convention.
Effect of Work Commitment, Supervision, and Discipline on the Quality of Work of Employees at PT. Bintang Saudara Semesta Jaya
Authors: Sibarani Hendra Jonathan , Choandy Dennis , Halim Suriyani
Published: December 2021

The purpose of this study was to determine the effect of work commitment, supervision, and discipline on the quality of work of employees of PT. Bintang Saudara Semesta Jaya, either partially or simultaneously. This research approach is based on a quantitative approach. This type of research is a type of quantitative descriptive research. The population of this study are all employees of PT. Bintang Saudara Semesta Jaya, which based on data obtained in October 2021, totaled 61 employees from all divisions except managers. The sampling technique used a saturated sample so that the sample used was representative of the entire population, namely 61 people. The data analysis technique used is multiple linear analysis technique. Hypothesis testing by means of Simultaneous partial (t test), (F test), and coefficient of determination (R2). The results of the study indicate that there is effect of work commitment on the quality of work of employees at PT. Bintang Saudara Semesta Jaya. There is effect of supervision on the quality of work of employees at PT. Bintang Saudara Semesta Jaya. There is effect of discipline on the quality of work of employees at PT. Bintang Saudara Semesta Jaya. Simultaneously there are effect of work commitment, supervision, and discipline on the quality of work of employees at PT. Bintang Saudara Semesta Jaya. The results of the regression calculation can be seen that the coefficient of determination (R square) obtained is 0.409, this result means that 40.9% of the quality of work of employees can be explained by the work commitment, supervision, and discipline, while the remaining 59.1% is explained by other variables which is not researched.

Keywords: Work Commitment, Supervision, Discipline, Quality of Work, Employees.
The Role of Local Village Facilitators in Empowerment in Medan Estate Village, Percut Sei Tuan District, Deli Serdang Regency
Authors: Purba Tomshon Manapar , Harahap R. Hamdani , Kusmanto Heri
Published: December 2021

The limitations of the village in management in various sectors, both in the economic, health, education and infrastructure sectors make the village the main focus of the government in implementing development. Based on Law Number 6 of 2014 concerning villages, making villages have an important role in the implementation of development and empowerment. One of the implementations of the village law is by issuing village fund programs that are prioritized in achieving sustainable development goals (SDGs). To assist the government in accelerating the achievement of the SDGs, the Minister of Villages, Development of Disadvantaged Regions and Transmigration Regulations Number 19 of 2020 concerning Amendments to the Regulation of the Minister of Villages, Development of Disadvantaged Regions and Transmigration Number 18 of 2019 concerning General Guidelines for Assisting Village Communities has been presented. Medan Estate Village is located in Percut Sei Tuan District, Deli Serdang Regency. Community empowerment can be carried out by local village assistants who assist in facilitating the achievement of SDGs data collection starting from socialization to inputting data on applications. The purpose of this study was to determine the role of local village facilitators in assisting empowerment activities in Medan Estate Village. This research method is descriptive qualitative research. The results of this study indicate that the role of local village assistants in facilitating the village government runs according to its duties but in empowering the community it has not run optimally. The supporting factor in mentoring is the openness of the village government in establishing cooperation and the obstacle in mentoring is the lack of village community participation in village meetings.

Keywords: Local Village Facilitators, Empowerment, Sustainable Development Goals.
Transformation of the Cosmetic Industry Due to the COVID-19 Pandemic
Authors: Farisha Mega , . Hartoyo , Safari Arief
Published: December 2021

The Covid-19 pandemic that occurred caused external shocks to every company, without exception, companies engaged in the cosmetic sector. This study aims to analyze the company's external factors that affect the strength of the company's external side and assess whether there is a potential for market development. This study uses a qualitative approach using PESTEL analysis. Data were obtained from interviews with resource persons related to cosmetic products (facial serum) and also from literature in the Jabodetabek area. This study resulted in a key success factor that can be adopted by businessman, namely understanding the behavior of cosmetic consumers, especially facial serum. By understanding consumer behavior, businessman can determine appropriate strategies according to each consumer group and can also improve the trademark performance of each facial serum business actor. In addition, the importance of innovating, transforming, and adapting quickly to a phenomenon (in this case the Covid-19 pandemic) makes business not stagnant, continues to grow and is able to capture new market potential.

Keywords: cosmetic, Covid-19, facial serum, key success factor, PESTEL analysis.
Formulation and Evaluation of Immediate Release Tablets of Etizolam
Authors: Kumar Singh Abhishek , Shakeel Kasif
Published: December 2021

In the present investigation, immediate release tablet formulation of etizolam was developed for management of insomnia and anxiety using different Superdisintegrants (Sodium Starch Glycolate, Croscarmellose, Crospovidone), Povidone K-30 and Magnesium stearate by wet granulation method. The drug-excipients interaction was investigated by UV spectrophotometer. The granules and tablets of Etizolam were evaluated for various pre and post compression parameters like angle of repose, compressibility index, hausners ratio, tablet hardness, friability and in vitro disintegration and dissolution studies and their results were found to be satisfactory. These results suggest that maximum in vitro dissolution profile of formulation F6 were found to have equivalent percentage of drug release and concluded that F6 is better and similar to innovator product.
Preparation and Evaluation of Diclofenac Sodium Effervescent Tablet
Authors: Savant P.B. , Qureshi M.A. , N. Kshirsagar , Kareppa Manjusha , B Thalkari Avinash , Karwa P.N.
Published: December 2021

The oral dosage forms are the most popular way of taking medicine although having some disadvantages like deliberate absorption and thus onset of action is extend. This can be overcome by administrating the drug in a liquid form i.e. effervescent tablet. The research is a formulation of diclofenac sodium as a effervescent tablet by wet granulation method. The bitter taste of the drug are masked by added sweetening agent (lactose, glucose etc.) In the present work we are prepared effervescent tablet in that we are used active drug diclofenac sodium and other active ingredient acid like tartaric acid and base sodium bicarbonate in different concentrations. The formulation of tablet was done by using wet granulation, wet granulation is found to be acceptable method of effervescent tablet formulation. The various pre-formulation studies was performed hardness, weight variation, disintegration, dissolution etc.
Nose to Brain Drug Delivery System
Authors: D Patil Gayatri , R Nikam Aditya , A. Patil Paresh , D. Sonar Aakash
Published: December 2021

The treatment of brain disorders is particularly challenging due to the presence of a variety of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brain-barrier (BBB) constitutes the major obstacle to the uptake of drugs into the brain following systemic administration. An intranasal delivery provides some drugs with short channels to bypass the blood-brain barrier (BBB), especially for those with fairly low brain concentrations after a routine delivery, thus greatly enhancing the therapeutic effect on brain diseases. The nasal mucosa is nearby the brain, cerebrospinal fluid (CSF) and the drug concentrations can exceed plasma concentrations. a longer retention time at the nasal mucosal surface, penetration enhancement of the active through the nasal epithelia, and a reduction in drug metabolism in the nasal cavity. Indications where nose-to-brain products are likely to emerge first include the following: neurodegeneration, post-traumatic stress disorder, pain, and glioblastoma.
A Decisive Review to Understand the Basic Fundamentals of Novel Corona Viruse Disease
Authors: Sweta Sweta , Singh Navdeep
Published: December 2021

With the development and spread of 2019 novel coronavirus (2019-nCoV), also known as the severe acute respiratory syndrome coronavirus 2, a new public health disaster is threatening the world (SARS-CoV-2). In December 2019, the virus was discovered in bats and transmitted to humans via unidentified intermediary species in Wuhan, Hubei Province, China. To date (05/03/2020), there have been roughly 96,000 recorded cases of coronavirus disease 2019 (COVID-2019) and 3300 documented deaths. The disease is spread through inhalation or contact with contaminated droplets, with a 2 to 14-day incubation period. Fever, cough, sore throat, dyspnea, weariness, and malaise are common symptoms. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it can lead to pneumonia, ARDS (acute respiratory distress syndrome), and multi-organ failure. A large number of persons are asymptomatic. The case fatality rate is expected to be between 2 and 3%. Specimen collection, assay collection, serology, nucleic acid testing or molecular testing, and target selection for RT-PCR are all examples of laboratory diagnosis. Home isolation of suspected cases and those with mild illnesses, as well as tight infection control measures in hospitals, including contact and droplet precautions, are all part of the prevention strategy. The virus has a lower fatality rate than its two ancestors, SARS-CoV and Middle East respiratory sickness coronavirus (MERS-CoV). The global consequences of this new epidemic are still unknown.
Review on Antifungal Agents
Authors: Shirsat Sangita P. , Tambe Kaveri P. , Dhakad Ganesh G. , Patil Paresh A. , Jain Ritik. S.
Published: December 2021

There are so many type of daisies are founded because of ‘Fungal’ such daisies given in follow. also the treatment on this particular daisies with the help of ‘Anti-fungal’ drug or anti- fungal agent and anti-fungal medication as follows The four main classes of antifungal drugs are the polyenes, Azoles, allylamines and echinocandins. Clinically useful “older” agents include topical azole Formulations (for superficial yeast and dermatophyte Infections), first-generation triazoles (fluconazole and Itraconazole, for a range of superficial and invasive fungal Infections), amphotericin B formulations (for a broad range of Invasive fungal infections) and terbinafine (for dermatophyte Infections). Clinically important “newer” agents include members of the Echinocandin class (eg, caspofungin) and second-generation Triazoles (eg, voriconazole and posaconazole). Voriconazole and posaconazole have broad-spectrum activity Against yeasts and moulds, including Aspergillus species. Posaconazole is the only azole drug with activity against Zygomycete fungi. Caspofungin and the other echinocandins are effective in Treating Candida and Aspergillus infections. The azoles are relatively safe, but clinicians should be aware of drug–drug interactions and adverse effects, including Visual disturbances (with voriconazole), elevations in liver Transaminase levels, and skin rashes. Caspofungin has Minimal adverse effects. Combination antifungal therapy may be appropriate in Selected patients with invasive fungal infections, but is Empiric and driven by individual physician practice. Clinical needs for novel antifungal agents have altered
Basic Concepts of Sterilization Techniques
Authors: Kumar Ravi , Rana Atul
Published: December 2021

Sterilization, which is any process, physical or chemical, that destroys all forms of life, it is used especially to destroy microorganisms, spores, and viruses. Precisely defined, sterilization is the complete destruction of all microorganisms by a suitable chemical agent or by heat, either wet steam. In this review, we discussed about various suitable techniques that used for removing of infectious agents. The heat sterilization can be applied only to the thermostable products, and chemical sterilization is also used for any types of plastic or glass materials that degrade with heat. The Gas sterilization involves exposing equipment to chemical gases in an enclosed heated or pressurized chamber.
Review on Adverse effects or side effects of Remdisivir
Authors: Dhakad Ganesh G. , V. Patil Rohit , I. Chaudhari Tejas , A. Patil. Paresh
Published: December 2021

In March 2020, the World Health Organization declared the spread of SARS-CoV-2 a global pandemic. To date, coronavirus disease-2019 (COVID-19) has spread to over 200 countries, leading to over 1.6 million cases and over 99,000 deaths. Given that there is neither a vaccine nor proven treatment for COVID-19, there is currently an urgent need for effective pharmacotherapy. To address the need for an effective treatment of SARS-CoV-2 during the worldwide pandemic, this systematic review of intravenous (IV) remdesivir was performed. Remdesivir, an anti-viral prodrug originally developed to treat Ebola virus disease, has shown broad spectrum activity against the Coronavirus family. A recent case report reported improvement of clinical symptoms with remdesivir in a patient with COVID-19. After conducting a systematic search of 18 clinical trial registries and three large scientific databases, we identified 86 potentially eligible items. Following removal of duplicates (n = 21), eligible studies were reviewed independently by two authors. After the first round of screening, inter-rater agreement was 98.5% (κ = 0.925). After the second round of full-text screening, inter-rater agreement was 100%. A total of seven ongoing and recruiting clinical trials of remdesivir (100–200 milligrams, intravenous [IV]) were included. We identified the following primary outcomes: patients discharged (n = 2); time to clinical status improvement (n = 2); improved O2 saturation (n = 2); body temperature normalization (n = 2); and clinical status (n = 1). Secondary outcomes in all identified studies included documentation of adverse events. Phase 3 trials are expected to be completed between April 2020–2023. Therefore, despite supportive data from in vitro and in vivo studies, the clinical effectiveness of IV remdesivir for treatment of COVID-19 and potential side effects remain incompletely defined in the human population. But the remdesivir is also harmful for the people because of it can have some side effects such as mentioned in the following information. There are so many type of disease started form the treatment of COVID-19 with the Remdesivir that also mentioned in the following review paper.
The Pharmacological Study of Antidiabetatic Property of Ficus racemosa Leaves by Observing Different Aspects
Authors: J. Rodge Prasad. , Sayyed Irfan , Bhosle Vitthal , S. Jain Ritik. , Z. Shaikh Azam.
Published: December 2021

Ficus racemosa is belong to the family of Moraceae.It is a famous medicinal plant in India which is used in traditional system of medicine for long period of time for the treatment of various diseases like liver disorder, diarrhora, inflamatory condition, ulcer, urinary disorder, antifungal and diabetics. This plant is very useful from ancient time of maintained in Ayurveda, Siddha, Unani and Homeopathy. Plant are one of the most important role/source in medicine. The commen name of Ficus racemosa is “Audumber” and “Umbar”. In Thervada Buddhism the plant is said to have as the tree for achived enlightenment by the 26th Loard Buddha, Konaagama. This udumbara is deciduous tree. The more information is described below and the people are moving towards ayurvedic preprations.
An Overview on Invasomes: Novel Vesicular Carrier for Transdermal Drug Delivery
Authors: Pandey Swarnima , Srivastava Vikas
Published: December 2021

Multifunctional organ of the human body is the skin and it has less porousness across the layer corneum and this layer is the hindrance for dynamic specialists. To expand the penetrability of dynamic specialists, novel vesicular transporter invasomes are presented. Invasomes give different preferences including upgrading patient consistence, improving the medication adequacy and increment the pervasion of hydrophilic medications. This is a vesicular transporter that improves the Transdermal infiltration contrasted with ordinary liposomes. Invasomes comprise of phospholipid, terpenes, ethanol, and water. These constituents assume a significant part in improving its infiltration capacity. In this review paper, a wide presentation of TDDS (transdermal medication conveyance framework) is clarified and different segments, strategies for arrangement, segments, benefits, and faults of invasomes are featured.
Ten food that boost Immune System: A Review
Authors: N. Vikhe Dattaprasad
Published: December 2021

The immunity and system functions to fight against infections square measure considerably wedged by inappropriate food and nutrition. Long run deficiency disease is universally thought-about because the leading explanation for system deficiency. A considerable proportion of the worldwide population doesn't meet the counselled daily intake of nutrient. The COVID-19 pandemic has targeted attention on the role of the system, with health scientists and nutritionists urging folks to require supplements and/or eat specific foods (nutrients) to super-charge their immune systems. The system is that the most complicated system of physical structure. For this we have a tendency to needed the supplements like food for maintenance of system.in this article here could be a discussion of foods like Citrus fruits like lemon, orange, lime etc., broccoli, spinach, turmeric, yoghurt, kiwi, garlic, papaya, almonds, ginger, tulsi, etc things helps in boosting our immunity to fight against infections. In this report, foods that helps in maintain system or immunity boosting material is mentioned.
A Review on Coronavirus
Authors: B. Chavan Mahesh. , Tarade Durgesh , H. Pagare Kushan. , S. Jain Ritik.
Published: December 2021

Coronavirus disease also termed as covid-19 or SARS-COV-2 infection has been declared as global pandemic disease by World Health Organization (WHO). The first case of covid-19 is reported at the local Huanan Seafood wholesale market in Wuhan city in Hubei in central chain at last of 2019. Covid-19 is rapidly spread throughout the world since December – 2019 from Wuhan city of China. Covid-19 patient has various symptoms like fever, cough, sore throat, breathlessness, fatigue and others. It is very necessary to identify the cases of covid-19 as soon as possible and isolate the suspected people and confirmed cases of Covid-19 to prevent the infection to other peoples.
Frequently Experienced Problems in the Early Stages after Prescribing Rigid Gas Permeable Contact Lenses
Authors: Lee Dong Ho
Published: December 2021

Prescribing rigid gas-permeable (RGP) lenses involves a series of processes that determine the most appropriate final lens through the trial use of test lenses based on the results of slit lamp microscopy, measuring refraction and corneal curvature, and corneal topography. The final prescription is reached by judging the dynamic lens movement, adequacy of the tear layer around the lens, corrected vision, and quality of vision. Various problems are encountered soon after prescribing lenses, including foreign body sensation, tear hypersecretion, decreased visual acuity, blurring, visual acuity change, redness, dryness, sudden pain, lens centering, and lens fallout. Here, we examine these problems and how to solve them.
Severe Intraocular Pressure Fluctuation following Hemodialysis after Cataract Surgery in a Patient with Chronic Renal Failure
Authors: Joo Chan Woong , Park Sung Pyo , Na Kyeong Ik
Published: December 2021

Purpose: To report a case of severe intraocular pressure fluctuation following hemodialysis after cataract surgery in a patient with chronic renal failure.Case summary: A 51-year-old female patient on hemodialysis for chronic renal failure, who was seen regularly by our retina clinic for proliferative diabetic retinopathy and right eye cataract, presented with decreased visual acuity in her right eye. During phacoemulsification under the diagnosis of right eye cataract, zonular dialysis and posterior capsule rupture occurred and intraocular lens ciliary sulcus insertion was performed. Following hemodialysis 3 days after the surgery, the patient complained of headache and right eye pain. The intraocular pressure of the right eye had increased to 44 mmHg. Mild inflammation in the anterior chamber was found with remnant lens material present at the inferior anterior angle. The use of glaucoma eye drops, anterior chamber paracentesis, and anterior chamber irrigation reduced the intraocular pressure and improved the patient’s symptoms. However, a severe increase in intraocular pressure recurred with the above symptoms, again following hemodialysis. Intraocular pressure fluctuation was repetitively present after serial hemodialysis treatments for 1 month, at which point cataract and glaucoma surgeries were considered. However, the intraocular pressure stabilized afterwards; thus, the patient remained under observation and was treated with glaucoma eye drops.Conclusions: Inflammation and a decrease in the aqueous outflow facility due to remnant lens material and the use of an ophthalmic viscoelastic device in cataract surgery may cause severe intraocular pressure fluctuations in patients undergoing hemodialysis for chronic renal failure.