bluuebunny/crossref_metadata_2025 huggingface dataset:
Alleviating the Neglected Tropical Diseases: Recent Developments in Diagnostics and Detection
Authors: Hazra Satakshi , Patra Sanjukta
Published: November 2018

Background:

Neglected tropical diseases (NTDs) are communicable diseases caused by a
group of bacteria, viruses, protozoa and helminths prevalent in more than 145 countries that affect the
world’s poverty stricken populations. WHO enlists 18 NTDs amongst people living in endemic areas
having inaccessibility to preventive measures. Steps to reduce the global disease burden of the NTDs
need attention at multi-factorial levels. Control programmes, mass drug administrations, transmission
checks, eradication surveillances and diagnoses are some of them. The foremost in this list is confirmatory
diagnosis. A comprehensive summary of the innovative, high-impact, multiplexed, low-cost diagnostic
tools developed in the last decade that helped to meet the needs of users can depict a holistic approach
to further evaluate potential technologies and reagents currently in research.

Major Advancements:

A literature survey based on developing nano-biotechnological platforms to meet
the diagnostic challenges in NTDs towards development of a useful point-of-care (POC) unit is reported.
However, in order to pave the way for complete eradication more sensitive tools are required that are
user-friendly and applicable for use in endemic and low-resource settings. There are various novel research
progresses/advancements made for qualitative and quantitative measurement of infectious load in
some diseases like dengue, Chagas disease and leishmaniasis; though further improvements on the
specificity and sensitivity front are still awaited. Strategies to combat the problem of antimicrobial drug
resistance in diagnosis of NTDs have also been put forward by various research groups and organizations.
Moreover, the state-of-the-art “omics” approaches like metabolomics and metagenomics have also
started to contribute constructively towards diagnosis and prevention of the NTDs.

Conclusion:

A concrete solution towards a single specimen based common biomarker detection platform
for NTDs is lacking. Identifying robust biomarkers and implementing them on simple diagnostic
tools to ease the process of pathogen detection can help us understand the obstacles in current diagnostic
measures of the NTDs.
New Hybrids Derived from the Natural Compound (-)-β-Pinene and Amides or Acylthioureas as Antitumor Agents
Authors: Liao Shengliang , Rao Xiaoping , Shen Minggui , Si Hongyan , Song Jie , Shang Shibin , Song Zhanqian
Published: November 2018

Background:

Plant-derived natural compounds have a unique molecular structure and rich biological activity, hence, they are treated as important raw materials for the development of drugs.

Methods:

A natural compound (-)-β-pinene was used as a raw material, and twenty-six novel derivatives with amide or acylthiourea groups were synthesized based on the molecular hybridization method. In vitro antitumor activity of these derivatives on human breast cancer cell line MCF7 and human colon cancer cell line SW1116 were tested by MTT method. The effects of the synthesized derivatives on the morphology of MCF7 and SW1116 were observed by fluorescent inverted microscope.

Results:

The preliminary structure-activity relationship analysis demonstrates that the position and species of substituents on the aromatic ring of derivatives have an effect on the antitumor activity of derivatives. Observation of the cell morphology reveals that derivatives with antitumor activity can lead to rounding of the cell morphology, a decrease in cell volume and cell density, and ultimately inhibition of the proliferation of MCF7 and SW1116 cells. The antitumor activity evaluation results show that among these derivatives, compounds 5c, 5e, 5h, 7c, 7b and 7e exhibit good antitumor activity against MCF7, and compounds 5c, 5e, 5h and 7j exert moderate antitumor activity against SW1116.

Conclusion:

This study hopes to promote the high value-added utilization of natural compounds β-pinene and the development of novel antitumor drugs.
Phytochemicals in Anticancer Drug Development
Authors: Dutt Rohit , Garg Vandana , Khatri Naveen , Madan Anil K.
Published: November 2018

Background:

In spite of major technological advances in conventional therapies, cancer continues to remain the leading cause of mortality worldwide. Phytochemicals are gradually emerging as a rich source of effective but safer agents against many life-threatening diseases.

Methods:

Various phytochemicals with reported anticancer activity have been simply categorized into major phytoconstituents- alkaloids, polyphenols, saponins, tannins and terpenoids.

Results:

The adverse effects associated with currently available anticancer medications may be overcome by using plant-derived compounds either alone or in combination. Exploration of plant kingdom may provide new leads for the accelerated development of new anticancer agents.

Conclusion:

Although numerous potent synthetic drugs have been introduced for cancer chemotherapy, yet their serious toxicity concerns to normal cells apart from drug resistance have emerged as the major obstacles for their clinical utility over a prolonged duration of time. Current status and potential of phytochemicals and their derivatives in cancer therapy have been briefly reviewed in the present manuscript.
Leukocytoclastic Vasculitis Associated with HHV6-A/ciHHV6-A and HHV6-B Coinfection in an Immunocompetent Woman
Authors: Calvario Agata , Foti Caterina , Scarasciulli Maria , Romita Paolo , Eliassen Eva , Marzullo Andrea , Colacicco Anna Maria , Miragliotta Giuseppe
Published: November 2018

Background and Objective: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis that can be limited to the skin but may also affect other organs. Often, its cause is unknown. LCV has previously been reported to occur with the reactivation of human herpesvirus 6 (HHV-6). Here, we report a second instance of HHV-6 reactivation in a 43-year-old woman with idiopathic cutaneous LCV.  Case Description: In this case, the patient was immunocompetent, and testing revealed that she had inherited chromosomally integrated human herpesvirus 6 variant A (iciHHV6-A) with a parallel skin infection of HHV-6B. The integrated ciHHV-6A strain was found to be transcriptionally active in the blood, while HHV-6B late antigen was detected in a skin biopsy. The patient’s rash was not accompanied by fever nor systemic symptoms and resolved over four weeks without any therapeutic intervention.

Conclusion:

In light of the transcriptional activity documented in our case, further examination of a possible role for HHV-6 in the etiology of LCV is warranted.
An Efficient Tool for Searching Maximal and Super Maximal Repeats in Large DNA/Protein Sequences via Induced-Enhanced Suffix Array
Authors: Kumar Sanjeev , Agarwal Suneeta , Ranvijay
Published: November 2018

Background:

DNA and Protein sequences of an organism contain a variety of repeated
structures of various types. These repeated structures play an important role in Molecular biology as
they are related to genetic backgrounds of inherited diseases. They also serve as a marker for DNA
mapping and DNA fingerprinting. Efficient searching of maximal and super maximal repeats in
DNA/Protein sequences can lead to many other applications in the area of genomics. Moreover, these
repeats can also be used for identification of critical diseases by finding the similarity between
frequency distributions of repeats in viruses and genomes (without using alignment algorithms).

Objective:

The study aims to develop an efficient tool for searching maximal and super maximal repeats
in large DNA/Protein sequences.

Methods:

The proposed tool uses a newly introduced data structure Induced Enhanced Suffix Array
(IESA). IESA is an extension of enhanced suffix array. It uses induced suffix array instead of classical
suffix array. IESA consists of Induced Suffix Array (ISA) and an additional array-Longest
Common Prefix (LCP) array. ISA is an array of all sorted suffixes of the input sequence while LCP
array stores the lengths of the longest common prefixes between all pairs of consecutive suffixes in
an induced suffix array. IESA is known to be efficient w.r.t. both time and space. It facilitates the
use of secondary memory for constructing the large suffix-array.

Results:

An open source standalone tool named MSR-IESA for searching maximal and super maximal
repeats in DNA/Protein sequences is provided at https://github.com/sanjeevalg/MSRIESA. Experimental
results show that the proposed algorithm outperforms other state of the art works w.r.t. to
both time and space.

Conclusion:

The proposed tool MSR-IESA is remarkably efficient for the analysis of DNA/Protein
sequences, having maximal and super maximal repeats of any length. It can be used for identification
of well-known diseases.
EFECTOS DEL GASTO PÚBLICO EN EL PIB EN LOS ESTADOS DE MÉXICO, 1999-2014
Authors: Díaz Carreño Miguel Ángel , Mejía Reyes Pablo , Reyes Hernández Marlen R. , Desiderio de la Cruz Ana
Published: November 2018

RESUMEN

El objetivo de esta investigación es analizar el efecto del gasto público en el producto interno bruto (PIB) a nivel estatal en México. El periodo de estudio abarca de 1999 a 2014 y empleamos un modelo  de regresión cuantílica para explicar dichos efectos. Encontramos que el gasto público total ha sido relevante en la explicación del crecimiento económico estatal, sobre todo en aquellos estados más grandes del país. En estos casos el coeficiente resultó positivo y significativo. Por otra parte, el gasto público realizado en infraestructura resultó no significativo en la explicación del pib tanto en el caso de los estados grandes como en los pequeños.

 

EFFECTS OF PUBLIC SPENDING ON THE GDP IN THE STATES OF MEXICO, 1999-2014

  ABSTRACT

The objective of this paper is to analyze the effects of public expenditure on Gross Domestic Product (GDP) over the period 1999-2014 for the Mexican states. By using a quantile regression, it is found that total public expenditure has been relevant in the explanation of economic growth, mainly in the case of the largest states with positive and significant effects. On the contrary, the public expenditure associated to infrastructure seems to have not contributed to economic growth of the states of any size.

 
PLANEACIÓN ÓPTIMA DE LA RED DE TRANSMISIÓN ELÉCTRICA DE BAJA CALIFORNIA SUR
Authors: Guerrero Daniel , Rosellón Juan
Published: November 2018

RESUMEN

Analizamos los efectos sobre bienestar social de dos distintos procesos de planeación de expansión de la red de transmisión. Un primer modelo (integrado) considera las decisiones de generación y transmisión como actividades interdependientes. Un segundo modelo (desintegrado) supone dichas decisiones de expansión independientes, tal que la expansión de la red sigue un proceso exógeno. Esta dualidad de enfoques ha sido motivo de discusión académica y de política pública en diversos sistemas, como es el caso del sistema eléctrico de Alemania. Los dos modelos se simulan para la red de transmisión de Baja California Sur, el cual es un sistema autocontenido, con relativamente pocos nodos y líneas, y que permite desarrollar un estudio realista sobre las características de expansión eficiente de su red eléctrica. Demostramos que el enfoque integrado de expansión de la red resulta en mayores niveles de bienestar social para distintas topologías de red de este sistema.

 

OPTIMAL PLANNING OF THE ELECTRIC TRANSMISSION NETWORK OF BAJA CALIFORNIA SOUTH

 ABSTRACT
We analyze the effects on social welfare of two different planning processes for the expansion of the transmission network. A first (integrated) model considers generation and transmission decisions as interdependent activities. A second model (disintegrated) assumes such expansion decisions as independent, such that the expansion of the network follows an exogenous process. This duality of approaches has been the subject of academic and public-policy discussion in various systems, as is the case of the German electricity system. The two models are simulated for the transmission network of Baja California Sur, which is a self-contained system with relatively few nodes and lines allowing a realistic study on the characteristics of efficient expansion within its electricity network. We demonstrate that the integrated network expansion approach results in higher levels of social welfare for different network topologies in this system.
 
C-reactive protein decrease associates with mortality reduction only in heart failure with preserved ejection fraction
Authors: Lourenço Patrícia , Pereira Joana , Ribeiro Ana , Ferreira-Coimbra João , Barroso Isaac , Guimarães João-Tiago , Leite-Moreira Adelino , Bettencourt Paulo
Published: November 2018

Aims

The prognostic role of high-sensitivity C-reactive protein (hsCRP) in acute heart failure is less well established than for chronic heart failure and the impact of its variation is unknown. We studied the impact of hsCRP variation in acute heart failure and whether it differed according to left ventricular function.

Methods

We analyzed patients prospectively included in an acute heart failure registry. Admission and discharge hsCRP were evaluated as part of the registry's protocol and its relative variation (ΔhsCRP) was assessed. ΔhsCRP during hospitalization =  [(admission hsCRP – discharge hsCRP)/admission hsCRP] × 100. Endpoint: all-cause death; follow-up: 3 years. A multivariate Cox-regression model was used to assess the prognostic value of ΔhsCRP (continuous and categorical variable: cut-off 40% decrease); analysis was stratified according to ventricular function.

Results

We studied 439 patients: mean age 75 years, 50.1% men and 69.2% had heart failure with reduced ejection fraction (HFrEF). Median discharge hsCRP was 12.4 mg/l and median ΔhsCRP was ∼40%. During follow-up 247 patients (56.3%) died: 73 (54.1%) heart failure with preserved ejection fraction (HFpEF) patients and 174 (57.2%) HFrEF patients. The multivariate-adjusted hazard ratio of 3-year mortality in HFpEF patients with hsCRP decrease of at least 40% during hospitalization was 0.56 (95% CI 0.32–0.99). A decrease of at least 40% in hsCRP was not mortality-associated in HFrEF patients. There was interaction between ΔhsCRP and left ventricular ejection fraction.

Conclusion

A decrease of at least 40% in hsCRP in acute heart failure was associated with a 44% decrease in 3-year death risk in HFpEF patients. No association between ΔhsCRP and prognosis existed in HFrEF patients. Inflammation appears to play a different role according to left ventricular function.
Modis Snowline Elevation Changes During Snowmelt Runoff Events in Europe
Authors: Parajka Juraj , Bezak Nejc , Burkhart John , Hauksson Bjarki , Holko Ladislav , Hundecha Yeshewa , Jenicek Michal , Krajčí Pavel , Mangini Walter , Molnar Peter , Riboust Philippe , Rizzi Jonathan , Sensoy Aynur , Thirel Guillaume , Viglione Alberto
Published: November 2018

This study evaluates MODIS snow cover characteristics for large number of snowmelt runoff events in 145 catchments from 9 countries in Europe. The analysis is based on open discharge daily time series from the Global Runoff Data Center database and daily MODIS snow cover data. Runoff events are identified by a base flow separation approach. The MODIS snow cover characteristics are derived from Terra 500 m observations (MOD10A1 dataset, V005) in the period 2000-2015 and include snow cover area, cloud coverage, regional snowline elevation (RSLE) and its changes during the snowmelt runoff events. The snowmelt events are identified by using estimated RSLE changes during a runoff event. The results indicate that in the majority of catchments there are between 3 and 6 snowmelt runoff events per year. The mean duration between the start and peak of snowmelt runoff events is about 3 days and the proportion of snowmelt events in all runoff events tends to increase with the maximum elevation of catchments. Clouds limit the estimation of snow cover area and RSLE, particularly for dates of runoff peaks. In most of the catchments, the median of cloud coverage during runoff peaks is larger than 80%. The mean minimum RSLE, which represents the conditions at the beginning of snowmelt events, is situated approximately at the mean catchment elevation. It means that snowmelt events do not start only during maximum snow cover conditions, but also after this maximum. The mean RSLE during snowmelt peaks is on average 170 m lower than at the start of the snowmelt events, but there is a large regional variability.
Seasonal Subsurface Water Contributions to Baseflow in the Mountainous Uhlířská Catchment (Czech Republic)
Authors: Šanda Martin , Vitvar Tomáš , Jankovec Jakub
Published: November 2018

Nine years of seasonal δ18O values in precipitation, soilwater and groundwater were evaluated in the Uhlířská catchment between 2008 and 2016 and recharge winter/summer ratios were calculated using δ18O values. The longterm average 18O content in groundwater is lower than the mean weighted 18O content in precipitation. This is explained by more than 50% of winter- and snowmelt- induced groundwater recharge that occurs in all years except of 2010 and 2013. The recharge of the peat organic soil water is balanced between summer and winter, whereas the mineral hillslope soil is dominantly recharged by summer precipitation. The 67% portion of baseflow, dominantly generated in the winter season, is composed of groundwater and peat organic soil water, according to the hydrochemical distribution of runoff components. Isotopic mass balance of individual winters shows that precipitation in warmer winters is entirely transformed into outflow until the end of the winter season, generating no significant water storage for potential drought periods
Influence of Mountain Spruce Forest Dieback on Snow Accumulation and Melt
Authors: Bartík Martin , Holko Ladislav , Jančo Martin , Škvarenina Jaroslav , Danko Michal , Kostka Zdeněk
Published: November 2018

Large-scale forest dieback was reported in recent decades in many parts of the world. In Slovakia, the most endangered species is Norway spruce (Picea Abies). Spruce dieback affects also indigenous mountain forests. We analysed changes in snow cover characteristics in the disturbed spruce forest representing the tree line zone (1420 m a.s.l.) in the Western Tatra Mountains, Slovakia, in five winter seasons 2013-2017. Snow depth, density and water equivalent (SWE) were measured biweekly (10-12 times per winter) at four sites representing the living forest (Living), disturbed forest with dead trees (Dead), forest opening (Open) and large open area outside the forest (Meadow). The data confirmed statistically significant differences in snow depth between the living and disturbed forest. These differences increased since the third winter after forest dieback. The differences in snow density between the disturbed and living forest were in most cases not significant. Variability of snow density expressed by coefficient of variation was approximately half that of the snow depth. Forest dieback resulted in a significant increase (about 25%) of the water amount stored in the snow while the snowmelt characteristics (snowmelt beginning and time of snow disappearance) did not change much. Average SWE calculated for all measurements conducted during five winters increased in the sequence Living < Dead < Meadow < Open. SWE variability expressed by the coefficient of variation increased in the opposite order.
Opinions of pediatric nurses about Jehovah’s Witnesses refusal of blood transfusion for their child
Authors: Jakubowska Klaudia , Kuczek Barbara , Wiśniewska Anna , Pilewska-Kozak Anna , Dobrowolska Beata
Published: November 2018

Introduction. Jehovah’s Witnesses absolutely refuse having blood transfusion performed. The situation is even more difficult when the refusal of blood transfusion concerns a child. Despite existing legal solutions, medical staff experiences value conflicts.

Aim. To analyze the opinions of pediatric nurses about problems that may arise in case of Jehovah’s Witnesses refusal of blood transfusion for their child.

Material and methods. Quantitative research was based on a diagnostic survey method. The variables were measured with the use of a survey questionnaire co-developed by the authors. A group of 104 pediatric nurses from the South-East Poland participated in the study.

Results. To the question “Have you ever encountered the situation throughout all your working career when parents refused their child to undergo a blood treatment due to their beliefs?”, 67.31% (n = 70) of the respondents replied the situation rarely happened. Half of the nurses surveyed (n = 52, 50.02%) admitted they did not accept the position of Jehovah’s Witnesses concerning blood treatment. Most of the nurses surveyed – 87.38% (n = 89) think the existence of procedures on how to proceed in this difficult situation is crucial, and 83% (n = 86) of the respondents admitted that there was no better solution than the already existing legal procedure.

Conclusions. The most difficult experience of pediatric nurses in the situation of Jehovah’s Witnesses refusal of blood transfusion for their child is in the opinion of surveyed nurses, endangering the child’s health or even life. Thus, most of the respondents agree that the best solution in that case is to implement a legal procedure that allows blood transfusion despite parents’ refusal.
Metode Hibrida Berbasis Preprocessing Data Untuk Peramalan Curah Hujan Jangka Panjang
Authors: Faulina Ria , Aini Nur
Published: November 2018

Salt as one of Indonesia's commodities is very dependent on the length of the dry season. The longer the dry season, the greater the process of evaporation of sea water pumped into the salting area. Rainfall is an indicator that is closely related to the dry season pattern in Indonesia. For this reason, it is necessary to have an early warning system to avoid crop failure in salt farmers. The research variables are rainfall, wind speed, and air temperature in Sumenep, Indonesia. Rainfall variables are determined as output variables (variables to be predicted), while wind speed and air temperature are input variables. In this study, the PCC-based ARIMA-ANFIS hybrid method was used to predict long-term monthly rainfall and examine the consistency of the resulting forecast so that it can be used to compile a yearly salt production calendar. The accuracy of the model in the prediction is measured based on the RMSE criteria. The result of this research is ARIMA model give the best accuracy than the recommended method.
Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides
Authors: Derosa Joseph , Kleinmans Roman , Tran Van , Karunananda Malkanthi , Wisniewski Steven , Eastgate Martin , Engle Keary
Published: November 2018

A nickel-catalyzed conjunctive cross-coupling of simple alkenyl amides with aryl iodides and aryl boronic esters is reported. The reaction is enabled by an electron-deficient olefin (EDO) ligand, dimethyl fumarate, and delivers the desired 1,2-diarylated products with excellent regiocontrol. Under optimized conditions, a wide range of amides derived from 3-butenoic acid, 4-pentenoic acid, and allyl amine are compatible substrates. This methodology represents the first example of regiocontrolled 1,2-diarylation directed by a native amide functional group. Computational analysis sheds light on potential substrate binding mode and the role of EDO ligand in the reductive elimination step.
ESIPT-Based Fluorescence Probe for the Ratiometric Detection of Superoxide
Authors: Wu Luling , Liu Liyuan , Han Hai-Hao , Tian Xue , Odyniec Maria , Sedgwick Adam , He Xiao-Peng , Bull Steven , James Tony
Published: November 2018

A simple ESIPT-based fluorescence probe (HMBT-LW) was developed for the detection of superoxide (O2⸱-). HMBT-LW was synthesised over two steps and was shown to rapidly detect low concentrations of O2⸱- (limit of detection = 7.4 μM), fully reacting within two minutes. Furthermore, HMBT-LW demonstrated excellent selectivity and sensitivity towards O2⸱-.
Ion Mobility Mass Spectrometry Measures the Conformational Landscape of P27 and Its Domains and How This Is Modulated upon Interaction with Cdk2/cyclin A
Authors: Beveridge Rebecca , Migas Lukasz , Kriwacki Richard , Barran Perdita E.
Published: November 2018

Intrinsically disordered proteins have been reported to undergo ‘disorder to order’ transitions upon binding to their partners in the cell. The extent of the ordering on binding and the lack of order prior to binding is difficult to visualize with classical structure determination methods. Binding of p27 to the Cdk2/cyclin A complex is accompanied by partial folding of p27 in the KID domain, with the retention of dynamic behaviour for function, particularly in the C-terminal half of the protein, positioning it as an exemplary system to probe conformational diversity. Here we employ native ion mobility with mass spectrometry (IM-MS) to measure the intrinsic dynamic properties of p27, both in isolation and within the trimeric complex with Cdk2/cyclin A. This stepwise approach reveals the conformational distributions of the constituent proteins and how they are restructured on complex formation; the trimeric Cdk2/cyclin A/p27-KID complex possesses significant structural heterogeneity cf. Cdk2/cyclin A. These findings support the formation of a fuzzy complex in which both the N and C termini of p27 interact with Cdk2/cyclin A in multiple closely associated states.
Apuntes para una Poética del Actor Teatral
Authors: Prado Zavala Jorge
Published: November 2018

En las siguientes líneas intentaremos desarrollar una descripción del quehacer artístico del actor teatral: su definición, sus funciones, su misión en el arte teatral y su participación específica en la creación del sentido escénico.
Perfil de dominancia cerebral en ingresantes a la universidad de Huancayo
Authors: Yarlequé Luis , Navarro Linda , Nuñez Edith , Padilla Maribel , Álvarez Gustavo
Published: November 2018

El trabajo que se presenta se encuadra en la investigación aplicada. Se trata de un trabajo dentro de la línea de la Educación superior de calidad, desarrollo y competitividad nacional, con el que se pretende establecer el perfil de dominancia cerebral de los ingresantes a la universidad en Huancayo. Se trabajó con una muestra de 363 estudiantes. Se empleó el método descriptivo con diseño descriptivo comparativo. Para la presentación de datos se utilizó tablas y gráficos. La prueba de hipótesis se procesó con la chi cuadrada de Pearson, los resultados hallados permitieron visualizar que los estudiantes universitarios que ingresan a la universidad tienen un perfil de dominancia el cuadrante B.
Modelo educativo y desafíos en la formación docente
Authors: Barrientos Gutiérrez Pedro
Published: November 2018

La formación docente bajo la visión mecanicista y fragmentaria de la educación está centrada en la transmisión de información científica académica, realizadas bajo la pedagogía de cumplimiento de contenidos programados y los principios de la educación de calidad. Esta práctica en la formación profesional de la educación genera limitaciones en el desempeño de la práctica educativa. Sin embargo, las demandas sociales actuales exigen la implementación de un modelo educativo que responda a una visión holística en la formación humana y profesional del docente con práctica de pedagogía del ejemplo en base a los fundamentos de la integridad y calidad educativa.
Política Social e processos de judicialização: Serviços sociais e famílias em foco
Authors: Mioto Regina Célia Tamaso , Dal Prá Keli Regina , Wiese Michelly Laurita
Published: November 2018

A precarização das políticas sociais impulsiona a crescente demanda ao Judiciário de solicitações vinculadas à garantia dos direitos, caracterizando os processos de judicialização. Pouco se discute que estes processos possuem face de controle e punição, o que tem demandado dilemas aos assistentes sociais nos serviços. O objetivo é discutir os processos de judicialização nas políticas de saúde e assistência social e evidenciar, na dinâmica dos serviços sociais, como se articulam tanto a face dos direitos, como a de controle das famílias. O estudo qualitativo foi desenvolvido nos serviços públicos de Santa Catarina, demarcando-os como espaços onde se tecem as relações entre a esfera executiva e judiciária. Os resultados indicam que a judicialização afeta os assistentes sociais pela disjunção entre as postulações da profissão e as exigências postas à política social e à responsabilização das famílias na provisão de bem-estar em evidência no contexto da política social brasileira
Apontamentos sobre a controvertida centralidade da família no trabalho social
Authors: Garcia Joana Angélica Barbosa
Published: November 2018

Este artigo discute o trabalho social com famílias na política de assistência social, com base na análise de orientações normativas produzidas neste campo e na observação de experiências profissionais. Alguns apontamentos são apresentados na forma de contribuição ao debate, entre eles a orientação da família como unidade do atendimento, o entendimento e o uso imprecisos da chamada matricialidade sociofamiliar, a fluidez do  companhamento familiar e sua adequação no trabalho com usuários e programas selecionados. O acompanhamento das famílias é apresentado como um expediente considerado necessário, porém frequentemente praticado com uma fundamentação precária, sem parâmetros a serem observados no tempo, em um ambiente institucional fragmentado e com frágil suporte de uma rede de proteção social. A análise das experiências em curso há mais de duas décadas indica a escassa e, por isso, necessária, adoção de indicadores que orientem o trabalho com famílias.
Protetores solares, pele negra e mídia em aulas de química
Authors: Vargas Regina Nobre , Faustino Gustavo Augusto Assis , Fernandes Fernanda Silva , Benite Anna Maria Canavarro
Published: November 2018

A exposição solar proporciona sensação de bem-estar físico, estimula a produção de melanina e a síntese de vitamina D pelo organismo. As civilizações antigas da África utilizavam base de mamona, extrato de magnólia, jasmim e óleo de amêndoas como protetores solares. Com características de uma pesquisa participante, este estudo teve como objetivo aproximar alunas/os do Ensino Médio de cientistas negras contemporâneas. Os resultados estabeleceram um diálogo sobre as radiações ultravioletas que incidem sobre a Terra pelos raios solares. Pessoas de pele negra representam a maioria da população do Brasil e, ainda assim, a veiculação de comerciais sobre protetores solares apresentam como alvo somente o corpo branco. A/o aluna/o reconhece o fenômeno da estratificação racial da população como construção ideológica realizada por meio de um conjunto de práticas materiais de discriminação racial. Portanto, cabe-nos como professoras/res de Química e sujeitos desta sociedade mediar o discurso que combata o racismo na educação.
Effect of grater position on the size of grated sago (Metroxylon spp.)
Authors: W.A. Wan Mohd Fariz , S. Rosnah , H. Azman , A. Mohd Shahrir , A. Saiful Azwan , S.H. Asnawi , M.S. Zainun
Published: November 2018

The natural arrangement of sago palm’s fiber orientation is parallel to the vertical axis of
the trunk. Extraction of the sago starch requires breaking of the trunk into fine sizes. The
sago size is affected by the grater position which affects the of starch recovery. This study
was conducted to evaluate grating efficiency through sago size produced at the different
direction of grating (0° and 90° to roller teeth rotation). Sago palm trunks without outer
layer were cut into square blocks of 100 mm3
. Each trunk block was placed on roller grater
platform at a different position where the cutting spike was parallel to the vertical axis of
sago trunk fiber orientation (grating at 0° direction) and perpendicular (grating at 90°
direction). 100 g of dry grated sago was sifted to determine the size distribution with
different sieve sizes i.e. 2.80 mm, 2.00 mm, 1.00 mm, 0.85 mm and 0.425 mm. A total
weight of 1 kg of grated sago was mixed with water and squeezed to be extracted. The
starch recovery produced by the grating process at 0° directionswas 10.30% higher than
900 directions. The present study showed that the direction of grating at 0° was able to
produce finer grated sago with maximum starch recovery.
DESIGN FRAMEWORK FOR URBAN MOSQUE IN THE CITY OF KUALA LUMPUR: A QUALITATIVE APPROACH
Authors: Asif Nayeem , Utaberta Nangkula , Sarram Arman , Ismail Sumarni
Published: November 2018

Thousands of years after the establishment of mosque as a place of worship, issues and problems regarding its continuous development, especially those stemming from complexity of modern living have created the need for urban planners and architects to reconsider its planning and design in regard with limited land availability, shortage of resources, accessibility and appropriate architectural expression. Thus the aim of this research is to find a proper definition for urban mosques in compact cities and point out the key considerations for the design of urban mosques. This research is conducted qualitatively through reporting on available design guidelines related to the current topic followed by a discussion on three mosques within the Malay Archipelago as the secondary data source. Consequently, three mosques within Kuala Lumpur, Malaysia were studied as a primary data source. The outcome of this research establishes a framework for possible design approach of urban mosque development as a basis for future mosques design in compact cities. The result can be utilized as a source of information for reference purpose as well as a possible guide on the effectiveness of urban mosque concepts, possible challenges in a compact city setting, vertical expansion, and sustainable development.
DESIGNING FOR AUTISM: AN ASPECTSS™ POST-OCCUPANCY EVALUATION OF LEARNING ENVIRONMENTS
Authors: Mostafa Magda
Published: November 2018

The objective of this paper is to demonstrate the application of the Autism ASPECTSS™ Design Index in the Post-Occupancy Evaluation of existing learning environments for children along the autism spectrum. First published in 2014 this index outlines 7 design criteria that have been hypothesized to support environments conducive of learning for children with autism spectrum disorder (ASD). Using the index as a framework, this paper outlines a case study of a Post-Occupancy Evaluation (POE) of an existing pre-K-8th grade public charter purpose-built school for children on the autism spectrum. The tools used for the evaluation were: the ASPECTSS scoring of the school through a survey of teachers and administrators; on-site behavioral in-class observation; and focus groups of parents, teachers, staff and administrators. The results informed a design retro-fit proposal that strived to assess any ASPECTSS compliance issues and implement the index across the learning spaces, therapy spaces, support services and outdoor learning environments of the school. This paper will outline the application of the index and the resultant design from this process. The results will strive to present a scalable and replicable methodology and prototype for improving existing built environments for learners with ASD.
HISTORY MATTERS: THE ORIGINS OF BIOPHILIC DESIGN OF INNOVATIVE LEARNING SPACES IN TRADITIONAL ARCHITECTURE
Authors: Abdelaal Mohamed Shokry , Soebarto Veronica
Published: November 2018

Recent empirical studies have shown a positive correlation between nature, the built environment and creativity in the human brain. During the medieval Islamic Golden Era, higher education buildings of non-medical ‘madrasa’ and medical ‘bimaristan’ institutions applied specific techniques and strategies so that human intellectual curiosity could flourish through direct and indirect contact with nature. In contrast, the architecture of modern universities has lessened students’ multisensory focus and engagement with nature. Several studies have addressed these institutions’ failure to foster the innovation-generation process. This systematic review summarises and synthesises previous studies, elaborating the characteristics of those spaces that can host Innovation-Generation Processes (IGPs) based on psychological and neurological investigation. The study analyses research outcomes that support the stimulative impact of nature on people’s cognitive capacities. This demonstrates that the biophilic design approach utilises natural conditions and elements within the built environment to enhance the physical, social, intellectual and psychological status of innovators. The findings of this study demonstrate a strong interrelationship between IGPs and the built environment in traditional higher education institutions based on the premise of biophilic design. Hence, we can adopt some lessons from these ‘timeless’ buildings to support the evolution of innovative university campuses today.
WOMEN’S ATTACHMENT AND CHILDHOOD EXPERIENCES OF RECREATIONAL PARKS IN KLANG VALLEY, MALAYSIA
Authors: Khairrussalleh Nadzirah , Hussain Norhuzailin , Ujang Norsidah
Published: November 2018

Childhood experiences influence attachment to recreational parks and green spaces in women’s adulthood. Studies have shown that the adults’ frequency of visiting recreational parks is correlated with the frequent visits during their childhood. This study examines women’s attachment and their childhood experiences. Questionnaire surveys were distributed to 510 women (as park users) involving two public parks namely Bukit Kiara and Bukit Jalil Recreational Parks. Results show majority of the respondents spent their leisure time in the parks for relaxing with family members. Most of the women were attached to the greenery of the landscape in the parks, as they associated the recreational park with relaxation and peaceful. The women’s childhood experiences with nature were identified as having a memorable family time, which was correlated with their positive attachment of the recreational park as adults. The findings can guide the park managers, planners and designers in providing a park that is responsive to the women’s needs and demands that can contribute to their emotional and social well-being.
THE GREEN ROOF THERMAL PERFORMANCE EVALUATION IN COMPARISON TO ASBESTOS CEMENT TILES APPLIED TO LIGHT STEEL FRAME BRAZILIAN BUILDINGS
Authors: Costa Angélica Felicidade Guião Marcato , Paschoalin Filho João Alexandre , Philipi Cortese Tatiana Tucunduva , Leite Brenda Chaves Coelho
Published: November 2018

This research aimed at comparing the thermal performance provided in experimental modules, one of which was performed with conventional cover, made of asbestos cement tiles; an another with green cover. The structure of the studied modules was executed using Light Steel Frame technique. As an experimental research, modules were built in a wide place, without the interference of shading. Instruments were installed in the inner part of the modules to measure the following data: air temperature, relative humidity. From the collected data, representative episodes have been chosen for the studies that aimed to compare the comfort provided by both modules, built with different roofs. As result, it was verified that the module with green roof had better performance than the module covered with asbestos cement tile in all selected episodes. The module covered with green roof maintained lower internal temperature variation throughout the days, indicating that the green roof has characteristic thermal insulation, reducing the heat flow from the roof.
UNDERSTANDING SOCIO-CULTURAL SPACES BETWEEN THE HADHAR AND BADU HOUSES IN KUWAIT
Authors: Al-Haroun Yousef AbdulMohsen , Al-Ajmi Mohammed Nasser
Published: November 2018

This study examines the socio-cultural spaces of the two major groups in Kuwait: the Hadhar and Badu. These groups are not an ethnic classification but are rooted in their historic settlements. The Hadhar refer to people who lived in old Kuwait town and were mostly merchants and artisans who made their living from the sea. The Badu on the other hand, most commonly referred to as Bedouins, are nomadic tribes who lived on the outskirts of old Kuwait town or in the Arabian Desert. This study employs cognitive maps to reveal fascinating insights into the lifestyles and cultural differences of these two groups as it relates to their domestic built environment. This study argues that house spatial organization is tightly coupled with a family’s socio-cultural traditions and values; hence, there are major spatial distinctions between the houses of the Hadhar and Badu. These differences are apparent in the houses’ main spaces such as the living hall, male guest reception space or diwaniya, and main entrance. This paper also contends that these differences are rooted historically in the traditional Hadhar mud brick courtyard houses and the traditional Badu Arabian tents. Although the oil boom and consequent impact of globalization transformed Kuwait’s houses into modern villas, on the inside they are still linked to each group’s traditional use of space.
RECENT DISCOURSE AND THE PROMISE FOR GLOBAL NETWORKS ON ARCHITECTURE AND URBANISM
Authors: Salama Ashraf M.
Published: November 2018

Archnet-IJAR: International Journal of Architectural Research has recently published an outline article that commemorated a decade of discourse and published research on architecture and urbanism since its inaugural issue of March 2007 and up to March 2017. The article offered a comprehensive coverage of the distinguished status of the journal being one of the top high quality journals. The purpose of the present article is provide reflections on some of what the journal has published since March 2017 and presents thoughts on latest developments including collaborations with academic and professional organizations and the move to Emerald; one of the prestigious global publishers in various areas and disciplines including relevant fields in built environment, place making, and urban planning and design. This will enable deepening and broadening existing relationships with various international research organizations and ensure that Archnet-IJAR remains a key channel for those organizations while meeting its promise for global coverage and presence.
Клінічна та морфологічна характеристика пейсмейкера хронічного панкреатиту
Authors: Kanikovskyi O. E. , Pavlyk I. V. , Oliinyk I. V.
Published: November 2018

Мета. Клінічно та морфологічно обгрунтувати поняття пейсмейкера хронічного панкреатиту (ХП).

Матеріали і методи. Проаналізовано результати хірургічного лікування 181 хворого з ХП, ускладненим синдромом панкреатичної гіпертензії.

Результати. З больовим синдромом типу В, що опосередковано вказує на тотальний тяжкий фіброз підшлункової залози (ПЗ), госпіталізовані 24,5% пацієнтів. Клінічно у всіх цих хворих виявлені множинні стриктури головної протоки ПЗ, інструментально - тканинний тиск спротиву (ТТС) понад 26,7 кПа (200 мм рт. ст.) та гістологічно - площа сполучнотканинних полів сягала (81,4 ± 6,62)%. Таким чином, пейсмейкером ХП слід вважати стриктуру  - зону максимального фіброзу та кальцеутворення головної протоки ПЗ і, що є основним, проток другого та третього порядків. Головка ПЗ була пейсмейкером ХП тільки у 83,8% спостережень, перешийок або тіло та хвіст ПЗ - у 16,2%.

Висновки. Ключовим у хірургічному лікуванні ХП є широке висічення стриктури (зони фіброзу) ПЗ, що забезпечує виконання комбінованої локальної резекції ПЗ за Frey-Izbicki, після якої частота виникнення рецидиву панкреатичної гіпертензії менша на 11,1%.
Мультидисциплінарний підхід до хірургічного лікування феохромоцитоми наднирників
Authors: Skums A. V. , Gulko O. M. , Kondratiuk B. A. , Symonov O. M.
Published: November 2018

Мета. Оцінити результати застосування мультидисциплінарного підходу в лікуванні феохромоцитоми наднирників.

Матеріали і методи. Для аналізу ефективності схеми періопераційного лікування проспективно та ретроспективно досліджено результати лапароскопічної адреналектомії (ЛА), виконаної з приводу феохромоцитоми у 31 хворого за період з 2015 по 2017 р. Пацієнтів розподілили на дві групи: 1-ша - 15 хворих, яким періопераційне лікування проводили із застосуванням мультидисциплінарного підходу, 2-га - 16 пацієнтів, яким виконали тільки ЛА. Аналізували середню тривалість оперативного втручання, середній об’єм інтраопераційної крововтрати, геодинамічні показники та ускладнення.

Результати. Середній об’єм інтраопераційної крововтрати у 1-й групі становив (48,7 ± 9,1) мл, у 2-й - (231,3 ± 113,8) мл (р < 0,05), середній рівень метанефрину в сечі до адреналектомії - відповідно (290,9 ± 71,8) та (991,2 ± 703,0) мкг/добу (р < 0,05). Середня тривалість оперативного втручання у пацієнтів 1-ї групи становила (117,7 ± 52,1) хв і була несуттєво меншою порівняно з пацієнтами 2-ї групи - (164,7 ± 57,5) хв (р = 0,133). Гемодинамічну нестабільність спостерігали лише у 5 пацієнтів 2-ї групи. Середні строки лікування після операції пацієнтів 1-ї групи становили (5,9 ± 2,2) дня, 2-ї - (11,3 ± 5,4) дня (p < 0,05). Ускладнення виникли у 2 (12,5%) пацієнтів 2-ї групи. Ніхто із пацієнтів обох груп не помер.

Висновки. У пацієнтів з феохромоцитомою наднирника періопераційне лікування із застосуванням мультидисциплінарного підходу є більш безпечним й ефективним та менш тривалим у порівнянні з виконанням тільки ЛА.
Прогностичне значення маркерів ендотеліальної дисфункції в діагностиці ступеня атеросклеротичного ураження коронарних судин у хворих із гострим інфарктом міокарда з коронарним стентуванням
Authors: Minukhina D. V. , Babadzhan V. D. , Boyko V. V. , Minukhin V. V. , Minukhin D. V. , Yevtushenko D. O.
Published: November 2018

Мета. Оцінити рівні інгібітора активатора плазміногену 1 типу (ІАП-1) та асиметричного діметіларгініну (АДМА) у хворих із гострим інфарктом міокарда (ГІМ) в залежності від наявності або відсутності цукрового діабету 2-го типу (ЦД2) та характеру ураження коронарних артерій (KА), а також їх прогностичне значення щодо ступеня атеросклеротичного ураження коронарних судин.

Матеріали і методи. Обстежено 130 хворих, 44 (33,85%) жінки та 86 (66,15%) чоловіків. Усіх пацієнтів розподілено на дві групи: основну - 73 хворих із ГІМ і супутнім ЦД2, серед них 43 чоловіки і 30 жінок, середній вік яких становив (62,73 ± 1,39) року, та порівняльну - 57 хворих із ГІМ без ЦД2, серед них 43 чоловіки і 14 жінок, середній вік яких становив (63,98 ± 1,47) року. Контрольну групу склали 20 практично здорових осіб (10 чоловіків і 10 жінок, середній вік яких становив (60,85 ± 1,37) року). Усім хворим проводили коронарографію вінцевих судин серця у стандартних проекціях за допомогою ангіографа Siemens Axiom Artis. Вміст АДМА встановлювали імуноферментним методом, використовуючи комерційну систему тестування «Immunodiagnostik» компанії ADMA Xpress ELISA Kit (Австрія), ІАП-1 - також імуноферментним методом, використовуючи комерційну тест-систему виробництва фірми Technoclone PAI-1 ELISA Kit (Австрія).

Результати. У хворих із ГІМ незалежно від того, мали вони ЦД2 чи не мали, рівні ІАП-1 та АДМА підвищені у порівнянні з контрольною групою (р < 0,05). У хворих з гемодинамічно значущим стенозом (ГЗC) KА (70% і більше) визначено підвищення рівнів ІАП-1 та АДМА як за наявності, так і за відсутності ЦД2 (р < 0,05).У хворих із ГІМ та дифузним ураженням (ДУ) KА як із супутнім ЦД2, так і без нього рівні ІАП-1 та АДМА були достовірно вище, ніж у хворих без ДУ KА (р < 0,05).

Висновки. Порівняння площ під ROC-кривими показало, що більшу діагностичну цінність для прогнозування ДУ KА у хворих із ГІМ та супутнім ЦД2 має ІАП-1, ніж АДМА. Рівні ІАП-1 та АДМА доцільно визначати для прогнозування ГЗC KА та діагностики ДУ коронарного русла з тим, щоб проводити профілактику розвитку ускладнень ГІМ.