bluuebunny/crossref_metadata_2025 huggingface dataset:
Loss of NPM2 Expression Is A Potential Immunohistochemical Marker for Malignant Peritoneal Mesothelioma : A Single-Center Study of 92 Cases
Authors: Wu He-liang , Yang Zhi-ran , Su Yan-dong , Ma Ru , Du Xue-mei , Gao Ying , Li Yan
Published: September 2022

Background
To explore the correlation between the expression level of nucleoplasmin 2 (NPM2) and the main clinicopathological characteristics and prognosis of malignant peritoneal mesothelioma (MPM).
Methods
Ninety-two postoperative specimens from MPM patients following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were collected. Postoperative specimens were stained with immunohistochemistry. The expression level of NPM2 was quantitatively analyzed by QuPath-0.3.2 software. Univariate and multivariate analyses were conducted to investigate the correlation between NPM2 expression and other conventional clinicopathological characteristics.
Results
Among the 92 MPM patients, there were 47 males (48.9%) and 45 females (51.1%), with a median age of 56 (range: 24–73). There were 70 (76.0%) cases with loss of NPM2 protein expression, 11 (12.0%) cases with low expression, and 11 (12.0%) cases with high expression. Univariate analysis showed that NPM2 protein expression level (negative vs. low expression vs. high expression) was negatively correlated with the following three clinicopathological factors: completeness of cytoreduction (CC) score, vascular tumor emboli, serious adverse events (SAEs) (all P < 0.05). Multivariate analysis showed that NPM2 protein expression level (negative vs. low expression vs. high expression) was independently negatively correlated with the following two clinicopathological factors: CC score [odds ratio (OR) = 0.317, 95%CI: 0.317–0.959, P = 0.042], vascular tumor emboli (OR = 0.092, 95%CI = 0.011–0.770, P = 0.028). Survival analysis showed that loss of NPM2 protein expression (negative vs. positive) was associated with poor prognosis of MPM.
Conclusions
Loss of NPM2 expression is a potential immunohistochemical marker for MPM.
CQFaRAD: Collaborative Query-Answering Framework for a Research Article Dataspace
Authors: Singh Mrityunjay , Pandey Shivam , Saxena Rohaan , Chaudhary Maheep
Published: September 2022

Dataspace systems cope with the problem of integrating a variety of data based on its structures and semantics such as structured, semi-structured, and unstructured data, and returns the best-effort or approximate answers to their users. The existing works on query answering in a dataspace system are content-based and paid attention to return the best answers to the users without taking care of their preferences. This paper aims to consider not only the content-based information but also the users' preferences while answering the users' queries. Therefore, we present a Collaborative Query-Answering Framework for a Research Article Dataspace (CQFaRAD) that helps to efficiently answer the users' queries and returns more prominent answers to them. In this work, we present a collaborative approach that adopts the advantages of existing content-based and users' preferences-based approaches. To achieve this task, we use the BERT model to represent our dataspace and users' query. We have validated our proposed approach on the research papers dataset available on Kaggle. The experimental results show that our approach works fairly well to return relevant information to the users.
Plating the hot potato – how to make intermediate bioenergy carriers an accelerator to a climate neutral Europe
Authors: Siegfried Konrad , Blümel Linda , Riedel Fabian , Moosmann David , Cyffka Karl-Friedrich , Richters Mark , Reumerman Patrick , Vos John , Matisons Magnus , Thrän Daniela
Published: September 2022

Background With bioenergy on a sustainable resource base in the European energy mix, intermediate bioenergy carriers (IBC) become of growing importance, as they can ensure a more efficient utilisation of biomass feedstocks from agricultural and forest residues [1]. A high potential for market uptake is foreseen for fast pyrolysis bio-oil (FPBO), one of several IBCs. While facing the chicken and egg problem in market entry, it is crucial to develop adequate strategies to support market implementation. Method With an adopted PESTEL method [2, 3], we analysed a promising value chain in which FPBO is produced from sawdust in Sweden and Finland, transported to the Netherlands and upgraded and marketed as a marine biofuel. Macro-environmental factors were collected, coded, and classified in so-called PESTEL + I categories (political, economic, social, technological, ecological, legal, infrastructural). Results Our results show that the market uptake of IBCs such as FPBO and subsequently produced biofuels above all is driven by the European Renewable Energy Directive II (RED II) [4]. In Annex IX Part A, sawdust is listed as a feedstock for advanced biofuels, which can be double counted towards the 14% renewable energy share goal in the transport sector in 2030. To support the use of advanced biofuels in the maritime and aviation sector, the proposal for revision of RED II 2021 contains a new multiplier (1.2x) for fuels delivered to these sectors, while all other multipliers are deleted [5]. These legal European obligations and implementation into national law of member states create strong incentives for many downstream market actors to use advanced biofuel. However, technological challenges for FPBO use such as metal interference with catalysts in fluid catalytic crackers in refineries and ongoing standardisation processes still hamper fast market introduction. Conclusions Overcoming technology challenges and the creation of long-term validity of guidelines and regulatory framework will create stable market conditions, investment security and finally will stimulate long-term offtake agreements between feedstock providers, technology developers and downstream customers.
Exercise stress electrocardiography using the two-minute jump test in children
Authors: Koyama Yutaro , Miura Masaru , Maeda Jun , Morikawa Yoshihiko , Yamagishi Hiroyuki
Published: September 2022

Although the treadmill and cycle ergometer are commonly used for exercise stress electrocardiography (ECG) testing, they are often difficult to perform with children. We herein evaluated the utility and safety of the two-minute jump test (2MJT) as a simple, alternative exercise test. One hundred patients, including 60 male patients, with an average age at study commencement of 10.7 ± 3.5 years (mean ± standard deviation) and with no exercise restriction who underwent a cardiac check-up between November 2020 and March 2022 at the study center were included. After recording their resting ECG, they jumped for two minutes during ECG recording, and the change in heart rate (HR), ECG findings, and occurrence of adverse events were investigated. The patients were asked to jump 185 ± 60 times in two minutes. As a result, their HR increased from 76 ± 13 beats/min at rest to 172 ± 18 beats/min at peak during the test. Ninety (90%) patients attained the ideal target HR of > 150 beats/minute. Five patients had abnormal ECG findings (ventricular extrasystoles, second-degree atrioventricular block, and atrial extrasystoles in two, two, and one patient, respectively) after loading but achieved complete spontaneous recovery within three minutes. Our findings suggested that the 2MJT is a useful and safe exercise test capable of inducing sufficient increase in HR in a short time in children.
Enhanced Pinch Flow Fractionation using inertial streamline crossing
Authors: de Timàry Guillaume , Cappello Jean , Scheid Benoit
Published: September 2022

In this work, we study the influence of inertia on the dynamics of neutrally buoyant spherical microbeads of varying diameter in a Pinch Flow Fractionation device. To that aim, we monitor their trajectory over an unprecedented wide range of flow rates and flow rate ratios. Our experimental results are supplemented by a depth-averaged 2D-model where the flow is described using the Navier-Stokes equation coupled with the shallow channel approximation and where particles trajectories are computed from Newton’s second law of motion with a particle tracing model. Above a certain flow rate, we show that particles inertia enables them to cross streamlines in response to an abrupt change of direction. These streamline crossing events combined with the increasing effect of the inertial lift forces drive particles to deviate from the inertialess trajectory. The amplitude of the resulting inertial deviation increases both with the particles diameter and the total flow rate before reaching a plateau. Consequently, based on our numerical and experimental results, we determine the optimal flow conditions to shift the particles distribution in order to significantly enhance their size-based separation.
Comparing model based iterative reconstruction to hybrid based iterative reconstruction in stenosis detection during ECG-gated coronary CTA
Authors: Maroun Gilbert , Ghosn Youssef , Serban Diana , Shattal Mohammad Abu , Wakim Wakim , Chokr Jad , Saade Charbel
Published: September 2022

Purpose: To compare the quantitative and qualitative image quality of hybrid (HBIR) and model based (MBIR) iterative reconstruction during coronary Computed Tomography Angiography (CTA). Materials and Methods: Institutional review board approved this retrospective study. Patients (n=200) underwent a single coronary CTA with two iterative reconstruction techniques. Group A employed HBIR and group B employed MBIR. Quantitative and qualitative image quality was compared for each group. The mean attenuation values and signal-to-noise ratio (SNR) of each group were compared. Visual grading characteristics (VGC) and Cohen’s Kappa methodology were measured employing an image quality scoring system for coronary CTA. Receiver operating (JAFROC) and stenosis severity were compared with conventional coronary angiography. A p-value <0.05 was considered statistically significant. Results: Mean attenuation values (HU) in the HBIR group were significantly greater in the cusp (564.18±118.71) and left coronary (517.59±118.63) whilst in the MBIR group, the right coronary (531.67±138.93), left anterior descending (529.82±120.6) and left circumflex (538.32±132.94) arteries were significantly higher (p<0.001). The SNR was significantly greater in MBIR (5.32±1.1) compared to HBIR (3.64±0.8) (p<0.0001), with MBIR being superior to HBIR in the total and individual segments of the coronary arteries. VGC image quality assessment demonstrated that readers preferred HBIR over MBIR (p<0.001). Analysis of JAFROC data demonstrated a significant difference in detection of coronary stenosis in RCA (p<0.021), LCA (p<0.0001) and LD (p<0.0001) with HBIR showing overall smaller variability range compared to MBIR. Conclusion: When comparing quantitative and qualitative image quality, MBIR was superior in the former, whilst HBIR was superior in the later. Coronary artery stenosis assessment demonstrated less variability in diagnosis when using HBIR compared to MBIR. This highlights the need for careful attention when employing iterative reconstruction in order not to impact clinical outcomes.
Identification of a novel HASPIN inhibitor and its synergism with the PLK1 inhibitor
Authors: Kwon Eun-Ji , Mashelkar Karishma K. , Seo Juhee , Shin Yoonze , Sung Kisu , Jang Sung Chul , Cheon Sang Won , Lee Haeseung , Han Byung Woo , Lee Sang Kook , Jeong Lak Shin , Cha Hyuk-Jin
Published: September 2022

Background: HASPIN, a mitotic kinase for Histone H3, is a promising target for anti-cancer therapy. However, as HASPIN is an atypical kinase with low similarity to eukaryotic protein kinases, development of a HASPIN inhibitor from the conventional pharmacophore of kinase inhibitors would be technically challenging. Methods: Chemical modifications of a cytotoxic 4’-thioadenosine analogue with high genotoxicity and multiple kinomescan profiles were performed to produce a novel non-genotoxic kinase inhibitor, LJ4827. The mode of action of this inhibitor with clear anti-cancer activity was inferred based on transcriptomic and chemical similarity to known drugs. Results: The specificity and potency of LJ4827 as a HASPIN inhibitor were validated by in vitro kinase screening and subsequent X-ray crystallography. As predicted, LJ4827 treatment delayed mitosis by clear inhibition of the recruitment of Aurora B at the centromere in cancer cells, without a genotoxic response. Through transcriptome analysis of lung cancer patients, PLK1 was predicted as a druggable synergistic partner to complement HASPIN inhibition. Cotreatment with the PLK1 inhibitor BI2536 and LJ4827 led to pronounced cytotoxicity of lung cancers in vitro and in vivo. Conclusion: Simultaneous inhibition of both HASPIN and PLK1 is a promising therapeutic strategy for lung cancers.
Effects of precipitation season and forest stand on selected ion deposition via through-fall in a rehabilitated forest
Authors: Ibrahim Mohamad Hilmi , Jaafar Salwana , Yamashita Naoyuki , Sase Hiroyuki
Published: September 2022

Less is known about studies into the effects of precipitation season and forest stands on ion deposition in restored forest ecosystems. In the present study, we measured and compared ion deposition (Ca²⁺, Na⁺, Fe²⁺, Cu²⁺, NO₃⁻, NH₄⁺, and SO₄²⁻) in rehabilitated forest sites in Bintulu, Sarawak, Malaysia. Through-fall ion depositions were measured with an ion-exchange resin (IER) sampler. In all forest stand years, Ca²⁺ and NH4+ depositions were consistently lower in the low precipitation season than in the high precipitation season, whereas there were no discernible patterns for Na⁺, Fe²⁺, Cu²⁺, NO₃⁻, or SO₄²⁻ between high and low precipitation seasons. The results also show that through-fall in forest stands in 2002, 2005, and 2008 had higher amounts of Ca²⁺ than through-fall in forest stands in 1996 and 1999 during both seasons. Through-fall from forest stands between 2008 and 2002 showed higher levels of Na⁺ and SO²− in low-precipitation seasons, whereas through-fall from forest stands from 1996 had higher levels in high-precipitation seasons. Overall, these results confirm the significance of rainfall volume and forest canopy stand in defining ion deposition status in the forest by demonstrating that ion deposition is influenced by precipitation season and forest stand via through-fall.
Cost Sharing Public Project with Minimum Release Delay
Authors: Guo Mingyu , Goel Diksha , Wang Guanhua , Yang Yong , Babar Muhammad Ali
Published: September 2022

We study the excludable public project model where the decision is binary (build or not build). In a classic excludable and binary public project model, an agent either consumes the project in its whole or is completely excluded. We study a setting where the mechanism can set different project release time for different agents, in the sense that high-paying agents can consume the project earlier than low-paying agents. The release delay, while hurting the social welfare, is implemented to incentivize payments to cover the project cost. The mechanism design objective is to minimize the maximum release delay and the total release delay among all agents. We first consider the setting where we know the prior distribution of the agents’ types. Our objectives are minimizing the expected maximum release delay and the expected total release delay. We propose the single deadline mechanisms. We show that the optimal single deadline mechanism is asymptotically optimal for both ob- jectives, regardless of the prior distribution. For small number of agents, we propose the sequential unanimous mechanisms by extending the largest unanimous mecha- nisms from Ohseto [7]. We propose an automated mechanism design approach via evolutionary computation to optimize within the sequential unanimous mechanisms. We next study prior-free mechanism design. We propose the group-based optimal deadline mechanism and show that it is competitive against an undominated mecha- nism under minor technical assumptions.
Spherical fuzzy programming approach to optimize the transportation problem
Authors: KAUR MANBIR , Yadav Rakesh
Published: September 2022

In any real-life problem, decision-making plays a very important role. It is always observable that uncertainty, hesitation, vagueness, etc. are involved in real-life situations. The existence of such factors increases the difficulty for the decision maker(s) to decide the accurate/precise, crisp value of parameters involved in the specific problem. In the present study, the uncertainty included in the transportation problem is dealt with by the proposed method based on the derived accuracy function. The function is derived using the centroid method and is further used to convert the fuzzy number into a crisp value in the proposed approach. The applicability and validity are presented with the numerical illustration. The superiority and comparative study are shown by applying it to the real-life transportation problem as a case study of Dinanagar city, India.
Examining relationship marketing and strategic branding in b2b Greek SMEs: A family business development
Authors: Samanta Irene
Published: September 2022

Α survey of relationship marketing, branding, and the family business life cycle is conducted to determine the extent to which these variables ensure their path to the next generation. The study examines whether interpersonal relationships apply to family SME businesses and how they adopt relationship marketing as their main strategy. The study provides an insightful benchmarking approach between family businesses in early stage (1st and 2nd generation) and well-established (3rd and 4th generation) companies. In addition, the adopted branding process is examined. A qualitative method was chosen for the interviews with five B2B Greek family companies in the trading sector. Family businesses are Greek, have a known brand name, and family members are involved in the decision-making process. All participants agree that personal or friendly relationships of the owner-founder with customers, suppliers, and staff are crucial at the launch of businesses, and growth is a synonym for business survival. Data analysis revealed that relationship marketing is not related to the stages of development, as different perceptions were observed among participants of well-established and companies in the early stage. The results also show a significant relationship between different stages of family business’s development and branding strategies, documenting that owners of well-established family businesses focus on organizational structure and culture. In contrast, owners of family businesses in the early stage rely on personal relationships. Branding strategy seems to be the appropriate approach for a family-owned business to survive in the marketplace and have succeed pass on to the next generations.
Characterization of bacteria from the genus Trueperella including their pathogenicity and antimicrobial resistance
Authors: KWIECIEŃ EWELINA , STEFAŃSKA ILONA , KIZERWETTER-ŚWIDA MAGDALENA , RZEWUSKA MAGDALENA
Published: September 2022

Gram-positive irregular rods from the genus Trueperella are opportunistic pathogens in animals, rarely causing infections in humans. Their pathogenicity is related to their adhesion properties, production of cytolysins, as well as ability to form biofilm and survive in host cells. Their pathogenesis and routes of infection are still poorly understood. In recent years, an increasing antimicrobial resistance has been noted in Trueperella spp., so the surveillance of the antimicrobial resistance of these bacteria seems to be very important. This study summarizes current knowledge about species belonging to the Trueperella genus, with a special focus on their pathogenicity and antimicrobial resistance.
Assessment of the microbiological quality and bactericidal properties of flavoured honey
Authors: Żebracka Anna , Winiarska-Mieczan Anna , Nowakowicz-Dębek Bożena , Banach Marcin , Drabik Agata , Pulit-Prociak Jolanta , Chmielowiec-Korzeniowska Anna
Published: September 2022

The aim of the study was to evaluate the microbiological quality and bactericidal properties of flavoured honeys. The study evaluated 20 different flavoured honeys available in Polish retail shops. These included 17 nectar honeys enriched with flavourings, i.e. herbs, marshmallow root, seaberry, elderberry, cranberry, hops, cloves, ginger, vanilla, black cumin, lemon, blackberry, strawberry, orange, raspberry, and European blueberry, as well as three creamed honeys with ginger and lemon grass, lemon and peppermint, and strawberry. The study showed that vast majority of the flavoured honeys were microbiologically safe and exhibited high bactericidal activity. The highest level of contamination was found in honey with black cumin and elderberry. The results showed that 50% honey solutions had a bactericidal effect against E. coli. Its growth was inhibited most strongly (20.6 mm) by nectar honey enriched with marshmallow root and elderberry. Similar properties of flavoured honeys were observed in the case of Salmonella Enteritidis. The zone of inhibition for honey with orange paste and cloves was on average 18.7 mm. The study showed that the honey had no effect at all on Pseudomonas aeruginosa, irrespective of the added flavourings.
Selected mechanisms of the antimicrobial effect of honey in the aspect of drug resistance of bacteria
Authors: MADRAS-MAJEWSKA BEATA
Published: September 2022

The aim of the study was to review the available literature on the significance of factors and mechanisms of the antimicrobial effect of honey and the possibilities of using them to stabilize or inhibit the growth of selected Gram-positive and Gram-negative pathogenic bacteria particularly capable of developing drug resistance. It can be concluded from data in the literature that the factors and mechanisms of the antimicrobial effect of honey are numerous and diverse. Honey can be effective in fighting microbes due to its physical, chemical and biological properties. The mechanisms of the antimicrobial effect of honey include, above all, high osmotic pressure, low pH caused by the presence of organic acids and hydrogen peroxide, high content of phenolic compounds, lysozyme (to a limited extent) and methylglyoxal in manuka honey and defenazine-1 in Revamil honey. Based on the presented research results, it was observed that the level of antibiotic activity of honey depends on its variety, geographic origin, concentration of honey solution, but also on the type of bacterial strain tested and its resistance. Bactericidal and bacteriostatic effects of various varieties of honey have been found in certain Gram-positive bacteria (manuka honey – Staphylococcus aureus; Scottish heather honey – Staphylococcus epidermidis) and Gram-negative bacteria (undiluted Thai honeys – Escherichia coli; 3% (v/v) solution of honey – Salmonella enterica; manuka honey – Pseudomonas aeruginosa biofilm). The high level of antibiotic activity of honey against these bacteria species is a potential opportunity to support therapies in cases of infections caused by these microorganisms, which can help fight the problem of drug resistance. The possibility of inhibiting or limiting the development of pathogenic bacteria without resorting to antibiotics would also have a mitigating impact on the growing problem of antibiotic resistance. However, it is advisable to extend the spectrum of research in this area to include bacteria species for which the current experimental results are mutually contradictory (Listeria monocytogenes, Enterococcus faecalis) and to include in the research microorganisms that have not yet developed drug resistance. In addition, both for economic reasons and due to the limited supply, alternative varieties of honey should be researched more extensively in research, apart from manuka honey which is most often used in experiments by scientists. In addition to the unquestionable advantages of honeys, it is important to remember that they can be contaminated with spores of Clostridium botulinum and Bacillus cereus.
Pelatihan Membaca Al-Quran dengan Metode Tahsin Tilawah untuk Meningkatkan Kualitas Bacaan Bagi Siswa SMA Muhammadiyah 1 Palembang
Authors: Firmansyah Firmansyah , Ali Mukti , Romli Romli
Published: September 2022

These community service activities were held on March 14-31, 2021, which were attended by 20 participants who joined the tahfidz program under the auspices of Al-Islam, Kemuhammadiyahan, dan Bahasa Arab (ISMUBA) and several students of Ikatan Pelajar Muhammadiyah (IPM) Muhammadiyah 1 Palembang High School. This training is carried out based on the needs of partners related to the evaluation of the implementation of the tahfidz program, namely the lack of attention of students to the quality Quran readings in memorized letters. To get maximum results, this training is done by participatory methods with service learning models. This training activity runs well and smoothly by the stages arranged in the schedule of implementation of activities. This is evident from the achievement of the training objectives and the enthusiasm and activeness of participants in training activities. The results achieved through this training are very significant towards increasing the knowledge and skills of participants in reading the Quran by tajwid rules, as well as increased motivation in memorizing the Quran by paying attention to the quality of Quran readings. Kegiatan pengabdian kepada masyarakat ini dilaksanakan pada tanggal 14-31 Maret 2021, yang diikuti oleh 20 peserta yang tergabung dalam program tahfidz di bawah naungan Bidang Al-Islam, Kemuhammadiyahan, dan Bahasa Arab (ISMUBA) dan beberapa siswa Pengurus Ikatan Pelajar Muhammadiyah (IPM) SMA Muhammadiyah 1 Palembang. Pelatihan ini dilakasanakan atas dasar kebutuhan mitra terkait dengan evaluasi pelaksanaan program tahfidz, yaitu kurangnya perhatian siswa terhadap kualitas bacaan Al-Quran pada surat-surat yang telah dihafal. Untuk menadapatkan hasil yang maksimal, pelatihan ini dilakukan dengan metode partisipatoris dengan model service learning. Kegiatan pelatihan ini berjalan dengan baik dan lancar sesuai dengan tahapan-tahapan yang disusun dalam jadwal pelaksanaan kegiatan. Hal ini terlihat dari ketercapaian terhadap tujuan pelatihan dan antusiasme serta keaktifan peserta dalam kegiatan pelatihan. Hasil yang dicapai melalui pelatihan ini sangat signifikan terhadap peningkatan pengetahuan dan keterampilan peserta dalam membaca Al-Quran sesuai dengan kaidah-kaidah tajwid, serta peningkatan motivasi dalam menghafal Al-Quran dengan memperhatikan kualitas bacaan Al-Quran.
Socialization and Training of Solar Power Generation (PLTS) at SD Negeri Tambakharjo Semarang
Authors: Kusmantoro Adhi - , Farikhah Irna
Published: September 2022

SD Negeri Tambakharjo Semarang uses PLN electricity with low installed power. The school is located in an area that has a total photovoltaic output power and solar radiation intensity of 1,486 Mwh/year and 1953.3 Kwh/m2/year.   The average output power per day of photovoltaic (solar panels) in October and November 2021 was 4551 Wh and 3778 Wh.  Therefore, the purpose of community service is to socialize the use of solar power plants (PLTS) through learning activities (education) and solar pv training for students and school teachers. The methods used in this activity are divided into three stages. In the first stage, field observations were carried out to find problems related to the availability of electrical energy in schools. In the second stage, the implementation of community service includes the delivery of solar panel material with lectures, demos, and solar power plant system designs in schools. In the third stage, it is the stage of evaluation or feedback by providing questionnaires to participants. The results of this service activity provide information data on understanding of solar panels and batteries in the good category. For practical activities, it needs to be improved to be taught for students in grades 5 and 6, so that solar pv props are indispensable in the school.
Essential Oils and their Chemical Constituents: The Potential Role in the Leukemic Diseases
Authors: Laghezza Masci Valentina , Ovidi Elisa , Garzoli Stefania
Published: September 2022

Essential oils (EOs), or the volatile fraction produced by aromatic plants,
possess a large number of biological activities. In the last few years, their possible use
in anticancer therapy has been under investigation. The anticancer potential of EOs
against leukemic diseases and their chemical composition have been reported in this
chapter, highlighting the in vitro studies against different cell models with their
cytotoxicity and the corresponding mechanism of action.
Plant-Derived Antimicrobial Compounds
Authors: Egamberdieva Dilfuza , Jabborova Dilfuza
Published: September 2022

The medicinal plants are widely used to treat diverse ailments and diseases,
including gastro-intestinal symptoms, cardiovascular diseases, skin disorders,
respiratory and infectious diseases, accelerating in recent years. Plants are rich in a
wide variety of secondary metabolites, such as alkaloids, tannins, flavonoids, and
phenolic compounds, found in vitro to have antimicrobial properties and could assist in
the discovery of novel drugs. The search for novel antimicrobial compounds, especially
against multidrug-resistant pathogens from aromatic and herbal plants, is an essential
line of scientific research. This review attempts to summarize the in vivo studies of the
antimicrobial activity of medicinal plants and their biologically active compounds. The
chemical composition of biologically active compounds with antimicrobial is also
addressed.
Diversity and Abundance of Insect on Shallot (Allium Ascalonicum L.) with Integrated Pest Management (IPM) and Conventional Patterns
Authors: Manna Dorkas Wantiawati , Afandhi Aminudin , Tarno Hagus
Published: September 2022

Research on diversity and abundance of insect on shallot with Integrated Pest Management (IPM) and conventional patterns has been carried out. This study aims to analyze diversity and abundance of insects, damage level of shallot, and relationship between diversity and abundance of insects with growth and production of shallot in IPM and conventional land. This research was conducted in Junrejo village, Batu City in September to December 2017 while identification of insect was carried out at the Laboratory of Plant Pest and Disease, University of Brawijaya. This study uses Yellow pan trap and Pitfall trap methods. The result showed diversity index (H') of IPM land was 2.50 and of conventional land was 2.67, which both are moderate diversity. The abundance of insect on IPM land is higher (8672 individuals) compared to conventional land (3475 individuals). The level of crop damage is lower in IPM land compared to conventional land, while shallot growth and production is higher in IPM land compared to conventional land.
Incremento de incidencia intradomiciliar de triatominos y prevalencia de Trypanosoma cruzi en el Centro de México
Authors: García-Mares José Israel , González-Acosta Cassandra , Peralta-Rodríguez Jorge , Correa-Morales Fabián , Barón-Olivares Héctor , Moreno-García Miguel
Published: September 2022

La enfermedad de Chagas afecta a millones de personas en América. La enfermedad está globalizada y en franca expansión, esto debido a la acelerada urbanización y a la expansión geográfica de chinches vectores (triatominos). La riqueza de de triatominos en México es alta (33 especies) pero varía por regiones. En Morelos, ubicado en el centro de México, se han reportado las especies Meccus pallidipennis, Triatoma barberi y T. dimidiata, con una prevalencia de infección alta. En este trabajo se describe el incremento de incidencia en ambiente intradomiciliar y el porcentaje de infección natural de triatominos en la zona oriente de Morelos. Se realizaron colectas activas intra y peri domiciliares de triatominos y se evaluó la presencia de T. cruzi en heces. Los resultados muestran que los casos de la enfermedad han ido en aumento con incremento en la preferencia intradomiciliar del triatomino. El índice de infección natural con Trypanosoma fue de 79.7 % para M. pallidipennis y del 49 % para T. barberi (no se detectó la presencia de T. dimidiata). Los resultados muestran que es necesario un incremento en los recursos económicos y humanos para generar estrategias de controles eficientes y sustentables de la enfermedad.
INTEGRASI PENDIDIKAN KARAKTER DALAM PERKULIAHAN
Authors: Winarni Sri
Published: September 2022

Abstrak: Membangun insan Universitas Negeri Yogyakarta (UNY) berkarakter dan bermartabat berarti mengintegrasikan pendidikan karakter dalam seluruh kegiatan di kampus. Strategi implementasi pendidikan karakter di kampus mestinya menyasar kepada seluruh sivitas akademika: mahasiswa, dosen, dan pegawai yang dilakukan melalui perkuliahan, kegiatan mahasiswa, dan manajemen. Model Nested dapat digunakan untuk mengintegrasikan beberapa keterampilan belajar: keterampilan berpikir, keterampilan sosial, dan keterampilan mengorganisir, dan juga soft skill. Pengintegrasian pendidikan karakter dalam perkuliahan dapat dilakukan dengan memasukkan nilai-nilai karakter dalam perencanaan (silabus dan RPP), bahan ajar dan media, implementasi di kelas, penilaian, monitoring, dan evaluasi kegiatan secara keseluruhan. Kata Kunci: integrasi pendidikan karakter, perkuliahan
PENGEMBANGAN PENDIDIKAN KARAKTER DAN BUDAYA BANGSA BERWAWASAN KEARIFAN LOKAL
Authors: Suyitno Imam
Published: September 2022

Abstrak: Pendidikan nasional Indonesia saat ini masih menghadapi berbagai masalah. Capaian hasil pendidikan masih belum memenuhi hasil yang diharapkan. Pembelajaran di sekolah belum mampu membentuk secara utuh pribadi lulusan yang mencerminkan karakter dan budaya bangsa. Proses pendidikan masih menitikberatkan dan memfokuskan capaiannya secara kognitif. Sementara, aspek afektif pada diri peserta didik yang merupakan bekal kuat untuk hidup di masyarakat belum dikembangkan secara optimal. Karena itu, pendidikan karakter dan budaya bangsa merupakan seatu keniscayaan untuk dikembangkan di sekolah. Sekolah sebagai pusat perubahan perlu mengupayakan secara sungguh-sungguh pendidikan yang berbasis karakter dan budaya bangsa. Karakter dan budaya bangsa yang dikembangkan di sekolah harus diselaraskan dengan karakter dan budaya lokal, regional, dan nasional. Untuk itu, pendidikan karakter dan budaya bangsa perlu dikembangkan berdasarkan kearifan lokal. Kata Kunci: pendidikan karakter, budaya bangsa, dan kearifan lokal
PENGINTEGRASIAN PENDIDIKAN KARAKTER DALAM PEMBELAJARAN DI SEKOLAH
Authors: . Marzuki
Published: September 2022

Abstrak: Pendidikan adalah proses memanusiakan manusia. Untuk meraih derajat manusia seutuhnya sangatlah tidak mungkin tanpa melalui proses pendidikan. Pendidikan harus dapat menghasilkan insan-insan yang memiliki karakter mulia, di samping memiliki kemampuan akademik dan keterampilan yang memadai. Salah satu cara untuk mewujudkan manusia yang berkarakter adalah dengan mengintegrasikan pendidikan karakter dalam setiap pembelajaran. Nilai-nilai karakter utama yang harus terwujud dalam sikap dan perilaku peserta didik sebagai hasil dari proses pendidikan karakter adalah jujur (olah hati), cerdas (olah pikir), tangguh (olah raga), dan peduli (olah rasa dan karsa). Pengintegrasian pendidikan karakter dalam pembelajaran dapat dilakukan dengan pemuatan nilai-nilai karakter dalam semua mata pelajaran yang diajarkan di sekolah dan dalam pelaksanaan kegiatan pembelajaran. Untuk itu guru harus mempersiapkan pendidikan karakter mulai dari perencanaan, pelaksanaan, hingga evaluasinya. Pelaksanaan pendidikan karakter di sekolah perlu didukung oleh keteladanan guru dan orang tua murid serta budaya yang berkarakter. Kata Kunci: integrasi pendidikan karakter, pembelajaran, sekolah INTERGATING CHARACTER EDUCATION IN THE TEACHING AND LEARNING AT SCHOOL Abstract: Education is the process of humanizing mankind. To achieve the degree of whole mankind is not possible without the educational process. Education should be able to produce human beings who have a noble character, in addition to academic ability and skills. One way to realize that human has noble character is to integrate character education in all learning. The main character values that should be embodied in the attitudes and behaviors of the students as a result of the process of character education is to be honest (conscience management), intelligent (intellectual management), stern (physical exercise), and care (sense and intent management). The integration of character education in the teaching and learning can be done by including the values in all the subjects taught in school and in the implementation of learning activities. For that character education, the teacher must prepare the teaching and learning activities from planning, implementation, until evaluation. The implementation character education at schools needs to be supported by exemplary teachers and parents as well as the conducive school culture. Keywords: integration of character education, teaching and learning, school
PENGEMBANGAN TUGAS MEMBACA UNTUK MEMBANGUN KARAKTER DI SEKOLAH MENENGAH ATAS
Authors: Zaidan Abdul Karim
Published: September 2022

Abstrak: Penanaman nilai atau karakter di sekolah khususnya di SMA tampaknya belum terwujud secara optimal. Oleh karena itu, penanaman karakter harus diintegrasikan pada semua mata pelajaran. Bahasa Inggris, sebagai salah satu mata pelajaran di sekolah juga harus mengembangkan dan mengintegrasikan karakter dalam proses pembelajarannya. Karakter tersebut dapat diintegrasikan dalam kurikulum melalui silabus, RPP, pendekatan atau metode pengajaran, evaluasi dan task yang meliputi tujuan pembelajaran, input atau materi pembelajaran, kegiatan pembelajaran, seting pembelajaran, peran guru dan peran siswa. Karakter harus direfleksikan melalui komponen task dalam keterampilan membaca. Kata Kunci: pendidikan karakter, tugas membaca, integrasi kurikulum DEVELOPING READING TASKS FOR CHARACTER BUILDING IN SENIOR HIGH SCHOOL Abstract: The nurturing of values or character at schools, particularly at the senior high schools has not been optimally realized. Therefore, it must be integrated in all the school subjects. English as one of the school subjects must also develop and integrate character in its teaching and learning process. The character can be integrated in the curriculum through its syllabus, lesson plans, approach to or method of teaching and learning, evaluation and tasks which include goal, input or the teaching and learning materials, teaching and learning activities, setting, the roles of the teacher, and the roles of the students. Character must be reflected through the components of tasks in the reading skill. Kata Kunci : character education, reading tasks, curriculum integration
PERCAYA DIRI, KEINGINTAHUAN, DAN BERJIWA WIRAUSAHA: TIGA KARAKTER PENTING BAGI PESERTA DIDIK
Authors: Salirawati Das
Published: September 2022

Abstrak: Pendidikan merupakan salah satu jalan keluar untuk membina karakter generasi muda secara terarah, terprogram, dan optimal agar dapat terbentuk generasi muda yang cerdas intelektual dan berkualitas akhlaknya. Percaya diri adalah karakter yang penting ditanamkan agar mereka menjadi generasi yang tidak mudah dipengaruhi hal-hal negatif di sekitarnya, optimis, dan tegar dalam menghadapi berbagai masalah dengan kemampuannya sendiri. Karakter keingintahuan diharapkan peserta didik suka pada tantangan, berinovasi dan kreatif menciptakan sesuatu yang dapat membanggakan dirinya, keluarga, dan negara. Jiwa wirausaha penting ditanamkan dan dikembangkan dalam diri peserta didik, mengingat di era globalisasi saat ini sangat diperlukan adanya SDM yang mampu bersaing. Karakter seperti ini tidak muncul serta merta, tetapi harus dibina secara dini. Penanaman nilai karakter yang terintegrasi dalam semua mata pelajaran dapat diharapkan nilai-nilai tersebut terinternalisasi dalam diri peserta didik. Materi yang dibelajarkan tidak hanya sebagai pengetahuan sekolah, tetapi juga menjadi pengetahuan dalam diri yang akhirnya ditunjukkan dalam bentuk perilaku. Kata Kunci: karakter, percaya diri, keingintahuan, berjiwa wirausaha
ASPEK BUDI LUHUR DAN MEMAYU HAYUNING BAWANA DALAM SASTRA MISTIK PENGHAYAT KEPERCAYAAN KAITANNYA DENGAN PENDIDIKAN KARAKTER
Authors: Endraswara Suwardi
Published: September 2022

Abstrak: Penulisan ini bertujuan (1) mendeskripsikan nilai budi luhur dan memayu hayuning bawana dalam teks sastra mistik penghayat kepercayaan (SMPK) kaitannya dengan pendidikan karakter; dan (2) memberikan pemahaman pragmatik sastra ke arah eksistensi ritual mistik kejawen modern. Teks SMPK terdiri dari banyak metrum puisi yang dijadikan bacaan pada saat melaksanakan ritual mistik kejawen sebagai upaya pendekatan diri kepada Tuhan. Data diambil teks-teks sastra mistik SMPK yang dibaca secara heuristik dan hermeneutik. Hasil kajian menunjukkan bahwa teks mistik memuat budi luhur ke arah memayu hayuning bawana yang merupakan upaya mencapai harmoni kosmos sebagai tanda keselamatan dunia. Selain itu, juga ditemukan tiga arah sifat hubungan budi luhur, yaitu (1) hubungan antara manusia dan Tuhan yang diwujudkan ke dalam perilaku manembah; (2) hubungan manusia dengan sesama yang memuat perilaku harus menyenangkan hati sesama; dan (3) hubungan manusia dengan diri sendiri yang intinya harus mengekang hawa nafsu. Kata Kunci: budi luhur, memayu hayuning bawana, penghayat kepercayaan, sastra mistik, pendidikan karakter
UPAYA PENUMBUHAN KARAKTER BERORIENTASI TINDAKAN MELALUI MODEL PENDAMPINGAN BISNIS MAHASISWA BERBASIS TEKNIK COACHING
Authors: Fitrihana Noor , Jerusalem M. Adam , Nurseto Tejo
Published: September 2022

Abstrak: PKM-K dan PMW diluncurkan Kemdikbud RI sebagai strategi mencetak lulusan yang ber- orientasi pencetak lapangan kerja. Salah satu masalah dalam program tersebut adalah ketidakefektif- an pendampingan bisnis oleh dosen. Akibatnya bisnis yang dijalankan mahasiswa tidak berkembang dan karakter entrepreneurships juga tidak tumbuh. Berorientasi pada tindakan merupakan salah satu karakter entrepreneurships terpenting dalam menunjang kesuksesan sesorang, tidak hanya di dunia bisnis namun juga di segala bidang. Penelitian ini bertujuan untuk meningkatkan karakter berorien- tasi pada tindakan melalui pengembangan model pendampingan bisnis mahasiswa yang efektif, efi- sien, dan terkurikulum. Pengembangan model menghasilkan model pendampingan bisnis mahasiswa yang terdiri atas tiga fase, yaitu review, coaching, dan challenge. Model ini efektif dalam merangsang mahasiswa untuk merancang dan melakukan tindakan bisnis untuk menumbuhkembangkan bisnis- nya. Kata Kunci: penumbuahn karakter, review, coaching, challenge, dan tindakan
PEMBENTUKAN KARAKTER PESERTA DIDIK MELALUI PENDIDIKAN BERBASIS AL-QURAN
Authors: Hakim Rosniati
Published: September 2022

Abstrak: Pembentukan kepribadian manusia (character building) yang seimbang, sehat dan kuat, sangat dipengaruhi oleh pendidikan agama dan internalisasi nilai keagamaan dalam diri peserta didik. Peletakan dasar-dasar pendidikan agama adalah kewajiban orang tua dan juga menjadi tugas guru, masyarakat, dan pemerintah melalui berbagai lembaga pendidikan. Tulisan ini membahas tentang pentingnya pendidikan Al-Quran, pendidikan berbasis Al-Quran, dan pembentukan karakter peserta didik melalui pendidikan. Pendidikan adalah sebuah proses yang tidak berkesudahan yang sangat menentukan karakter bangsa pada masa kini dan masa datang. Apakah suatu bangsa akan muncul sebagai bangsa yang berkarakter baik atau bangsa berkarakter buruk, sangat tergantung pada kualitas pendidikanyang dapat membentuk karakter anak bangsa tersebut. Pembentukan karakter melalui pendekatan pendidikan Al-Quran selain menjadi bagian dari proses pembentukan akhlak mulia, diharapkan mampu menjadi pondasi utama dalam meningkatkan derajat dan martabat peserta didik sebagai anak bangsa. Kata Kunci: karakter, kepribadian, pendidikan al-quran, akhlak, peserta didik LEARNERS’ CHARACTER BUILDING THROUGH AL-QURAN-BASED EDUCATION Abstract: the shaping of balanced, healthy and strong human character (character building) is highly influenced by religious education and the internalization of the religious values within the learners. The laying down of the religious education foundations is the obligation of the parents as well as the task of the teachers, the community, and the government through various educational institutions. This paper discusses the importance of the Al-Quran education, Al-Quran-based education, and the learners’ character building through education. Education is an endless process which determines the nation’s character today and in the future. Whether a nation will emerge as a nation of good or bad character highly depends on the quality of education that shapes the character of the children of the nation. Building the noble character through the Al-Quran education approach, other than being part of the process of building the noble character, is expected to become the cornerstone in improving the learners’ status and prestigeas children of the nation. Keywords: characters, personalities, alquran education, morals, learners
MEMBANGUN WAWASAN GLOBAL WARGA NEGARA MUDA BERKARAKTER PANCASILA
Authors: Murdiono Mukhamad , Sapriya Sapriya , Azis Wahab Abdul , Maftuh Bunyamin
Published: September 2022

Abstrak: Penelitian ini bertujuan untuk mengetahui bagaimana membangun wawasan global warga negara muda berlandaskan pada nilai-nilai Pancasila sebagai karakter bangsa Indonesia. Penelitian ini menggunakan pendekatan kualitatif dengan metode grounded theory. Sumber data terdiri dari sumber kepustakaan dan responden yang dipilih dengan menggunakan metode purposive sampling. Teknik pengumpulan data menggunakan studi dokumentasi dan wawancara. Analisis data menggunakan analisis induktif. Hasil penelitian menunjukkan bahwa nilai-nilai Pancasila sebagai karakter bangsa Indonesia harus dijadikan sebagai landasan dalam pengembangan wawasan global warga negara muda. Sila kedua Pancasila menjadi pintu utama pengembangan wawasan global warga negara muda. Pancasila sebagai landasan dalam pengembangan wawasan global warga negara, membawa implikasi bahwa warga negara muda di sekolah tidak hanya menjadikan nilai-nilai Pancasila sebagai slogan, melainkan harus diterapkan dan diimplementasikan dalam kehidupan sehari-hari. Kata Kunci: wawasan global, warga negara muda, Pancasila BUILDING A GLOBAL PERPECTIVE OF YOUNG CITIZENS HAVING PANCASILA CHARACTER Abstract: This research aims to find outhow to build a global perspective of young citizens based on the values of Pancasilaas the character of the Indonesian nation. This research used a qualitative approach with a grounded theory method. The data sources consisted of literature and respondents selected using a purposive sampling method. Data collection techniques used documentation and interviews. The data were analyzed using inductive analysis. The results showed that the values of Pancasila as the character of the Indonesian nation must be used as the basis to build a global insight of young citizens. The second pillar of Pancasila became the maingate to building a global insight of young citizens. Pancasila as the basis for building a global insight of young citizens brought the implication that young citizensin the school did not only use the values of Pancasila as a slogan, but must be applied and implemented in their daily lives. Keywords: global insight, young citizens, Pancasila