bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood pressure responses to the Cold Pressor Test according to body mass index and waist-to-height ratio in adolescents
Authors: Dos Santos Francinete Deyse , Pinto Edna Ferreira , Moura Ana Regina Leão Ibiapina , Carvalho Lima Eguinaldo Vinícius de , Souza Mariana Ferreira de , Carvalho Ferdinando Oliveira , Moraes José Fernando Vila Nova de
Published: September 2020

Objectives: to analyze the blood pressure (BP) values ​​and responses to the Cold Pressor Test (CPT) according to the body mass index (BMI) and the waist-to-height ratio (WHtR). Methods: 166 adolescents of both sexes participated in the study. Participants underwent measurements of body mass, height and waist circumference. BMI and WHtR were calculated. BP was measured before (pre-test), during (test) and after CPT (recovery). The groups were compared using a mixed ANOVA with Bonferroni post hoc, and Odds Ratio calculation. The level of significance was p < 0.05. Results: prevalences of 16.9% of high BMI, 19.9% ​​of increased WHR and 8.4% of pretest BP were found above the recommended. Participants with high BMI had increased systolic BP compared to their normal peers (113.0 ± 11.4 vs. 121.7 ± 11.6 mmHg; p = 0.003). Adolescents with elevated WHR had higher pre-test and recovery systolic BP (pre-test: 113.2 ± 11.4 vs. 119.6 ± 12.7 mmHg; p = 0.021; recovery: 111.9 ± 14.1 vs. 117.4 ± 14.0 mmHg; p = 0.044). Finally, individuals with BMI and WHtR above the recommended had 2.1 (95% CI 0.62 - 7.36) and 2.5 (95% CI 0.77 - 7.91) times, respectively, more likely to have high pre-test BP values. Conclusion: adolescents with increased BMI and WHtR have higher BP values ​​compared to their normal peers.
Особенности вольт-амперной характеристики гетероструктуры n-GaP--p-(InSb)-=SUB=-1-x-=/SUB=-(Sn-=SUB=-2-=/SUB=-)-=SUB=-x-=/SUB=-
Authors: Саидов А.С. , Лейдерман А.Ю. , Усмонов Ш.Н. , Асатова У.П.
Published: September 2020

The current-voltage characteristic of n-GaP--p-(InSb)1-x(Sn2)x (0 ≤ х ≤ 0.05) heterostructures has been studied. It has been shown that at low voltages V < 0.5 V, the current-voltage characteristic is described by the exponential law: I = I0exp (qV /ckT), and at large ones from 0.5 to 1.8 V power laws: I = A*V m with different values of the coefficient A and exponent m at various voltages. At higher voltages - from 2.10 to 2.48 V, a sublinear part is observed, which is described by the law: V= V0*exp(Iad / S).
Detection of Suicidality Among Opioid Users on Reddit: Machine Learning–Based Approach
Authors: Yao Hannah , Rashidian Sina , Dong Xinyu , Duanmu Hongyi , Rosenthal Richard N , Wang Fusheng
Published: September 2020

Background

In recent years, both suicide and overdose rates have been increasing. Many individuals who struggle with opioid use disorder are prone to suicidal ideation; this may often result in overdose. However, these fatal overdoses are difficult to classify as intentional or unintentional. Intentional overdose is difficult to detect, partially due to the lack of predictors and social stigmas that push individuals away from seeking help. These individuals may instead use web-based means to articulate their concerns.

Objective

This study aimed to extract posts of suicidality among opioid users on Reddit using machine learning methods. The performance of the models is derivative of the data purity, and the results will help us to better understand the rationale of these users, providing new insights into individuals who are part of the opioid epidemic.

Methods

Reddit posts between June 2017 and June 2018 were collected from r/suicidewatch, r/depression, a set of opioid-related subreddits, and a control subreddit set. We first classified suicidal versus nonsuicidal languages and then classified users with opioid usage versus those without opioid usage. Several traditional baselines and neural network (NN) text classifiers were trained using subreddit names as the labels and combinations of semantic inputs. We then attempted to extract out-of-sample data belonging to the intersection of suicide ideation and opioid abuse. Amazon Mechanical Turk was used to provide labels for the out-of-sample data.

Results

Classification results were at least 90% across all models for at least one combination of input; the best classifier was convolutional neural network, which obtained an F1 score of 96.6%. When predicting out-of-sample data for posts containing both suicidal ideation and signs of opioid addiction, NN classifiers produced more false positives and traditional methods produced more false negatives, which is less desirable for predicting suicidal sentiments.

Conclusions

Opioid abuse is linked to the risk of unintentional overdose and suicide risk. Social media platforms such as Reddit contain metadata that can aid machine learning and provide information at a personal level that cannot be obtained elsewhere. We demonstrate that it is possible to use NNs as a tool to predict an out-of-sample target with a model built from data sets labeled by characteristics we wish to distinguish in the out-of-sample target.
Online Patient Recruitment in Clinical Trials: Systematic Review and Meta-Analysis
Authors: Brøgger-Mikkelsen Mette , Ali Zarqa , Zibert John R , Andersen Anders Daniel , Thomsen Simon Francis
Published: September 2020

Background

Recruitment for clinical trials continues to be a challenge, as patient recruitment is the single biggest cause of trial delays. Around 80% of trials fail to meet the initial enrollment target and timeline, and these delays can result in lost revenue of as much as US $8 million per day for drug developing companies.

Objective

This study aimed to conduct a systematic review and meta-analysis examining the effectiveness of online recruitment of participants for clinical trials compared with traditional in-clinic/offline recruitment methods.

Methods

Data on recruitment rates (the average number of patients enrolled in the study per month and per day of active recruitment) and conversion rates (the percentage of participants screened who proceed to enroll into the clinical trial), as well as study characteristics and patient demographics were collected from the included studies. Differences in online and offline recruitment rates and conversion rates were examined using random effects models. Further, a nonparametric paired Wilcoxon test was used for additional analysis on the cost-effectiveness of online patient recruitment. All data analyses were conducted in R language, and P<.05 was considered significant.

Results

In total, 3861 articles were screened for inclusion. Of these, 61 studies were included in the review, and 23 of these were further included in the meta-analysis. We found online recruitment to be significantly more effective with respect to the recruitment rate for active days of recruitment, where 100% (7/7) of the studies included had a better online recruitment rate compared with offline recruitment (incidence rate ratio [IRR] 4.17, P=.04). When examining the entire recruitment period in months we found that 52% (12/23) of the studies had a better online recruitment rate compared with the offline recruitment rate (IRR 1.11, P=.71). For cost-effectiveness, we found that online recruitment had a significantly lower cost per enrollee compared with offline recruitment (US $72 vs US $199, P=.04). Finally, we found that 69% (9/13) of studies had significantly better offline conversion rates compared with online conversion rates (risk ratio 0.8, P=.02).

Conclusions

Targeting potential participants using online remedies is an effective approach for patient recruitment for clinical research. Online recruitment was both superior in regard to time efficiency and cost-effectiveness compared with offline recruitment. In contrast, offline recruitment outperformed online recruitment with respect to conversion rate.
The Role of Social Media in Enhancing Clinical Trial Recruitment: Scoping Review
Authors: Darmawan Ida , Bakker Caitlin , Brockman Tabetha A , Patten Christi A , Eder Milton
Published: September 2020

Background

Recruiting participants into clinical trials continues to be a challenge, which can result in study delay or termination. Recent studies have used social media to enhance recruitment outcomes. An assessment of the literature on the use of social media for this purpose is required.

Objective

This study aims to answer the following questions: (1) How is the use of social media, in combination with traditional approaches to enhance clinical trial recruitment and enrollment, represented in the literature? and (2) Do the data on recruitment and enrollment outcomes presented in the literature allow for comparison across studies?

Methods

We conducted a comprehensive literature search across 7 platforms to identify clinical trials that combined social media and traditional methods to recruit patients. Study and participant characteristics, recruitment methods, and recruitment outcomes were evaluated and compared.

Results

We identified 2371 titles and abstracts through our systematic search. Of these, we assessed 95 full papers and determined that 33 studies met the inclusion criteria. A total of 17 studies reported enrollment outcomes, of which 9 achieved or exceeded their enrollment target. The proportion of participants enrolled from social media in these studies ranged from 0% to 49%. Across all 33 studies, the proportion of participants recruited and enrolled from social media varied greatly. A total of 9 studies reported higher enrollment rates from social media than any other methods, and 4 studies reported the lowest cost per enrolled participant from social media.

Conclusions

While the assessment of the use of social media to improve clinical trial participation is hindered by reporting inconsistencies, preliminary data suggest that social media can increase participation and reduce per-participant cost. The adoption of consistent standards for reporting recruitment and enrollment outcomes is required to advance our understanding and use of social media to support clinical trial success.
Assessment of Myosteatosis on Computed Tomography by Automatic Generation of a Muscle Quality Map Using a Web-Based Toolkit: Feasibility Study
Authors: Kim Dong Wook , Kim Kyung Won , Ko Yousun , Park Taeyong , Khang Seungwoo , Jeong Heeryeol , Koo Kyoyeong , Lee Jeongjin , Kim Hong-Kyu , Ha Jiyeon , Sung Yu Sub , Shin Youngbin
Published: September 2020

Background

Muscle quality is associated with fatty degeneration or infiltration of the muscle, which may be associated with decreased muscle function and increased disability.

Objective

The aim of this study is to evaluate the feasibility of automated quantitative measurements of the skeletal muscle on computed tomography (CT) images to assess normal-attenuation muscle and myosteatosis.

Methods

We developed a web-based toolkit to generate a muscle quality map by categorizing muscle components. First, automatic segmentation of the total abdominal muscle area (TAMA), visceral fat area, and subcutaneous fat area was performed using a predeveloped deep learning model on a single axial CT image at the L3 vertebral level. Second, the Hounsfield unit of each pixel in the TAMA was measured and categorized into 3 components: normal-attenuation muscle area (NAMA), low-attenuation muscle area (LAMA), and inter/intramuscular adipose tissue (IMAT) area. The myosteatosis area was derived by adding the LAMA and IMAT area. We tested the feasibility of the toolkit using randomly selected healthy participants, comprising 6 different age groups (20 to 79 years). With stratification by sex, these indices were compared between age groups using 1-way analysis of variance (ANOVA). Correlations between the myosteatosis area or muscle densities and fat areas were analyzed using Pearson correlation coefficient r.

Results

A total of 240 healthy participants (135 men and 105 women) with 40 participants per age group were included in the study. In the 1-way ANOVA, the NAMA, LAMA, and IMAT were significantly different between the age groups in both male and female participants (P≤.004), whereas the TAMA showed a significant difference only in male participants (male, P<.001; female, P=.88). The myosteatosis area had a strong negative correlation with muscle densities (r=–0.833 to –0.894), a moderate positive correlation with visceral fat areas (r=0.607 to 0.669), and a weak positive correlation with the subcutaneous fat areas (r=0.305 to 0.441).

Conclusions

The automated web-based toolkit is feasible and enables quantitative CT assessment of myosteatosis, which can be a potential quantitative biomarker for evaluating structural and functional changes brought on by aging in the skeletal muscle.
Clinical Mortality in a Large COVID-19 Cohort: Observational Study
Authors: Jarrett Mark , Schultz Susanne , Lyall Julie , Wang Jason , Stier Lori , De Geronimo Marcella , Nelson Karen
Published: September 2020

Background

Northwell Health, an integrated health system in New York, has treated more than 15,000 inpatients with COVID-19 at the US epicenter of the SARS-CoV-2 pandemic.

Objective

We describe the demographic characteristics of patients who died of COVID-19, observation of frequent rapid response team/cardiac arrest (RRT/CA) calls for non–intensive care unit (ICU) patients, and factors that contributed to RRT/CA calls.

Methods

A team of registered nurses reviewed the medical records of inpatients who tested positive for SARS-CoV-2 via polymerase chain reaction before or on admission and who died between March 13 (first Northwell Health inpatient expiration) and April 30, 2020, at 15 Northwell Health hospitals. The findings for these patients were abstracted into a database and statistically analyzed.

Results

Of 2634 patients who died of COVID-19, 1478 (56.1%) had oxygen saturation levels ≥90% on presentation and required no respiratory support. At least one RRT/CA was called on 1112/2634 patients (42.2%) at a non-ICU level of care. Before the RRT/CA call, the most recent oxygen saturation levels for 852/1112 (76.6%) of these non-ICU patients were at least 90%. At the time the RRT/CA was called, 479/1112 patients (43.1%) had an oxygen saturation of <80%.

Conclusions

This study represents one of the largest reviewed cohorts of mortality that also captures data in nonstructured fields. Approximately 50% of deaths occurred at a non-ICU level of care despite admission to the appropriate care setting with normal staffing. The data imply a sudden, unexpected deterioration in respiratory status requiring RRT/CA in a large number of non-ICU patients. Patients admitted at a non-ICU level of care suffered rapid clinical deterioration, often with a sudden decrease in oxygen saturation. These patients could benefit from additional monitoring (eg, continuous central oxygenation saturation), although this approach warrants further study.
Rapid Implementation of Video Visits in Neurology During COVID-19: Mixed Methods Evaluation (Preprint)
Authors: Saliba-Gustafsson Erika A , Miller-Kuhlmann Rebecca , Kling Samantha M R , Garvert Donn W , Brown-Johnson Cati G , Lestoquoy Anna Sophia , Verano Mae-Richelle , Yang Laurice , Falco-Walter Jessica , Shaw Jonathan G , Asch Steven M , Gold Carl A , Winget Marcy
Published: September 2020

BACKGROUND

Telemedicine has been used for decades. Despite its many advantages, its uptake and rigorous evaluation of feasibility across neurology’s ambulatory subspecialties has been sparse. However, the COVID-19 pandemic prompted health care systems worldwide to reconsider traditional health care delivery. To safeguard health care workers and patients, many health care systems quickly transitioned to telemedicine, including across neurology subspecialties, providing a new opportunity to evaluate this modality of care.

OBJECTIVE

To evaluate the accelerated implementation of video visits in ambulatory neurology during the COVID-19 pandemic, we used mixed methods to assess adoption, acceptability, appropriateness, and perceptions of potential sustainability.

METHODS

Video visits were launched rapidly in ambulatory neurology clinics of a large academic medical center. To assess adoption, we analyzed clinician-level scheduling data collected between March 22 and May 16, 2020. We assessed acceptability, appropriateness, and sustainability via a clinician survey (n=48) and semistructured interviews with providers (n=30) completed between March and May 2020.

RESULTS

Video visits were adopted rapidly; overall, 65 (98%) clinicians integrated video visits into their workflow within the first 6 implementation weeks and 92% of all visits were conducted via video. Video visits were largely considered acceptable by clinicians, although various technological issues impacted their satisfaction. Video visits were reported to be more convenient for patients, families, and caregivers than in-person visits; however, access to technology, the patient’s technological capacity, and language difficulties were considered barriers. Many clinicians expressed optimism about future utilization of video visits in neurology. They believed that video visits promote continuity of care and can be incorporated into their practice long-term, although several insisted that they can never replace the in-person examination.

CONCLUSIONS

Video visits are an important addition to clinical care in ambulatory neurology and are anticipated to remain a permanent supplement to in-person visits, promoting patient care continuity, and flexibility for patients and clinicians alike.
Development of school canteen and school gardens guidelines as prevention against cardiovascular disease
Authors: Kandarina Bernadette Josephine Istiti , Hartriyanti Yayuk , Rahayujati Theodola Baning , Kurnia Arif Rahmat
Published: September 2020

Cardiovascular diseases are considered as the deadliest diseases in the world. According to WHO data, deaths caused by coronary heart disease in Indonesia reached 138,380 or 9.89% of the total deaths. The age adjusted mortality rate is 82.30 per 100,000 population with Indonesia ranked #97 in the world. Kulon Progo Regency is located in the western part of the Special Region of Yogyakarta.  The average monthly food expenditure in Kulon Progo is Rp365,012 ($27.49). While a healthy diet is known and promoted to benefit health, only a small portion is used to buy fruits and vegetables (2.24% and 1.76%). Cardiovascular disease is the main cause of morbidity in Kulon Progo. This study aimed to examine the process of developing guidelines for healthy school canteens and school gardens and promote fruit and vegetable consumption. This study used a qualitative research design. The data were collected through in-depth interviews and focus group discussions. A preliminary survey was conducted in 10 private and public schools in Kulon Progo district, Yogyakarta Province, Indonesia.  Guidelines related to healthy lifestyles through Canteen- and school garden were successfully arranged for in-school programs. Interviews and focus group discussions explored possibilities of permanently establishing the programs with local and national funding. Some disagreement was voiced concerning the loss of revenue incurred by local food vendors. Stakeholder involvement is crucially important for the preparation and development of the school canteen - and school gardens guidelines. Follow-up is recommended to carry out the dissemination of the guidebook.
Relationship between understanding of COVID-19's infographics and the efforts to prevent COVID-19 transmission
Authors: Bakhtiar Rahmat , Hilda Hilda , Duma Krispinus , Yudia Riries Choiru Pramulia
Published: September 2020

The prevention of disease transmission is an effective cost-strategy in controlling COVID-19. The scenario of the control of COVID-19 in Samarinda City consists of 3 phases, namely initial, advanced, and recovery. The outcome of the advanced phase is flattening the transmission curve of the COVID-19 pandemic, with an increased proportion of patients in recovery, and an increased culture of preventing disease transmission in society. This study aimed at knowing the influence of the understanding of COVID-19 infographics on the efforts to prevent COVID-19 transmission at the advanced phase. A survey was conducted via social media from April 21st to April 30th, 2020. The preventive actions for the disease transmission as the dependent variable in this study were social distancing, wearing a mask, washing hands, and efforts to enhance the body’s immunity, while the independent variable was the understanding of COVID-19 infographics updated daily. The results of the study showed that the proportion of the population who understood the infographics well was 79.5%, the community participation in practicing social distancing (81.6%), wearing a mask  (50.9%), washing hands as frequently as possible (74.3%), and the efforts to strengthen the body’s immune system (73.6%) with a consistency level of 55.12%. The lowest rate for the activity of social distancing was visiting elders or the people suffering from comorbidities with 54.71%. A good understanding of infographics could increase adherence to the recommendations of social distancing. The implementation of social distancing, wearing a mask, washing hands as frequently as possible, and the efforts to improve the body’s immune system need to be done consistently to prevent the COVID-19 transmission and as a result, the potential transmission could be minimized to optimize the recovery phase and anticipate the possible second wave of the COVID-19 pandemic.
COVID-19 eye infection: recommendations for ophthalmologist and patients
Authors: Respatika Datu , Mahayana Indra Tri , Puspita Dwi , Ilyasa Guiddo , Supartoto Agus
Published: September 2020

Coronavirus disease (COVID-19) is a public health emergency of international concern as declared by the World Health Organization on 30 January 2020. Currently, COVID-19 is spreading rapidly worldwide, with no proven treatment nor vaccination, thus infection control measures are paramount. The severity of the majority of COVID-19 cases is mild to moderate, with fever as its most common symptoms, followed by dry cough and fatigue. COVID-19 initially reported to be transmitted from bats but then evolved into human-to-human via droplets. Coronavirus has been detected in tears and conjunctival secretions, but there is still a controversy about whether the virus can be transmitted through tears. However, the ocular transmission might be transported through a lacrimal duct to nasopharyngeal mucosa and then cause an infection. Because the nature of close contact in doctor-patient interaction during ophthalmologic practice, strict measures must be taken to minimize the impact both on the patients and health care workers.
Tool-use experiments to determine the function of an incised ground stone artefact with potential symbolic significance
Authors: Hayes Elspeth , Spry Caroline , Fullagar Richard , Tuechler Anna , Schell Petra , Goulding Megan
Published: September 2020

Ground stone implements are found across most Australian landscapes and are often regarded as Aboriginal tools that were used for processing or modifying other items such as plant foods, plant fibres, resins, bone points, pigments and ground-stone axes and knives. Less common are ground stones modified for non-utilitarian, symbolic purposes; for example, polished and carved stone ornaments; ritual implements such as cylcons and tjuringa sacred stones; and unused, well-crafted ground-stone axes. In this paper, we report on the function and potential significance of an unusual ground stone artefact from a site near Bannockburn, southwestern Australia. A set of regularly spaced, shallow grooves has been cut into the surface of each side of the stone. Use-wear, residues and experimental replica tools indicate that the grooves were probably made with a stone flake and then used to shape or sharpen wooden implements such as spear points or the edges of boomerangs or other weapons. The microscopic wear outside the grooves indicates contact with soft wood or other plant material, possibly a soft plant fibre bag. We suggest that the Bannockburn artefact primarily functioned as a woodworking tool, but the even spacing of the incisions suggests that they were intentionally placed, perhaps to convey a special meaning, perhaps as a tally system or other form of communication.
Red sandstone as raw material of Baden culture (Late Copper Age) grinding stones (Balatonőszöd - Temetői dűlő site, Hungary), with a review of the red sandstone formations of SW Hungary
Authors: Péterdi Bálint
Published: September 2020

Balatonőszöd - Temetői dűlő is one of the largest excavated and longest-lived sites of the Late Copper Age Baden Culture in Hungary, where 500 lithic finds were registered. In the site finds belonging to the late Middle Copper Age Balaton-Lasinja Culture and the Late Copper Age Boleraz Culture were found too.

This paper presents petrographic and geochemical analyses of stone utensils, mostly of grinding stones, made of red, or discoloured white sandstones.

Almost all sandstone artefacts are upper and lower stones of grinding equipment and polishers, as well as objects whose function is not known, worked and non-worked fragments; boulders of raw material are also in the studied set.

The detailed petrographic and geochemical methods applied here are polarized light microscopy and a distribution study of the framework grains in thin section, and ICP-OES and ICP-MS as bulk rock chemical methods. The results were compared to published petrographic and geochemical data.

Most of the studied artefacts were made of the rocks of the Red Sandstone and Siltstone Member of the Balaton Highland Sandstone Formation, especially from the mature type sandstone in which quartz is predominant, and which is almost free of feldspar. This type is characteristic of the confines of the Southern Balaton Highland and the lower part of the formation in the Northern Balaton Highland.

A minor part of the studied artefacts - red or purple, purplish grey sandstones - originates from the sandstones of the Jakabhegy Sandstone Formation (Western Mecsek mountains).
From near and far: Stone procurement and exchange at Çukuriçi Höyük in Western Anatolia
Authors: Schwall Christoph , Brandl Michael , Gluhak Tatjana M. , Milić Bogdana , Betina Lisa , Sørensen Lasse , Wolf Danilo , Horejs Barbara
Published: September 2020

The focus of this paper are the stone tools of Çukuriçi Höyük, a prehistoric site situated at the central Aegean coast of Anatolia. The settlement was inhabited from the Neolithic, through the Late Chalcolithic and Early Bronze Age 1 periods, a period lasting from the early 7th to the early 3rd millennium BCE. A long-term interdisciplinary study of the excavated lithics with different scientific methods on various stone materials (thin section analysis, pXRF, NAA, LA-ICP-MS) offer new primary data about the procurement strategies of prehistoric societies from a diachronic perspective. The results will be presented for the first time with an overview of all source materials and their distinct use through time.

The lithic assemblages from Çukuriçi Höyük consist of a considerable variety of small finds, grinding stones and chipped stone tools. The high variability of raw materials within the different categories of tools is remarkable. In addition to stone tools manufactured from sources in the immediate vicinity of the settlement (i.e., mica-schist, limestone, marble, amphibolite, serpentinite), others are of rock types such as chert, which indicate an origin within the broader region. Moreover, volcanic rocks, notably the exceptionally high amount of Melian obsidian found at Çukuriçi Höyük, attest to the supra-regional procurement of distinct rock types. Small stone axes made of jadeite presumably from the Greek island of Syros, also indicate these far-reaching procurement strategies.

The systematic and diachronic analyses of the stone tools found at Çukuriçi Höyük has demonstrated that as early as the Neolithic period extensive efforts were made to supply the settlement with carefully selected raw materials or finished goods procured from distinct rock sources.
Lava rotary querns of ‘Iron Age type’ in Roman times
Authors: Wenzel Stefan
Published: September 2020

In Mayen the production of lava rotary querns of ‘Iron Age type’ continued from the late La Tène period into Julio-Claudian times. The lower quernstone possessed a domed grinding face and the upper stone was double concave in section. While the surfaces of these querns are usually pecked, late examples show a segmented radial grooving on the grinding surfaces. Handle sockets with elbow-shaped (L-shaped) perforation were already an innovation of the late Iron Age.
Since Augustan times ‘typical Roman’ hand-mills were the main product of the Mayen quarries. They had a meta with a flat conical grinding surface and a catillus with a broad raised rim. The active surfaces were grooved for functional reasons. However, the upper side of the catillus and the sides of upper and lower stones were grooved for decoration, making these rotary querns a characteristic ‘branded’ product.
Most of the ‘Iron Age type’ quernstones of Early Imperial times are known from the Low Countries where they go under the name of Brillerij-type. A survey of these quernstones reveals several examples found to the southeast of this region. Even after the typical Roman hand mills became the dominant form, some ‘vintage’ Iron Age type querns were still produced for a special clientele. Though, so far, virtually no closely dated specimens are known from contexts after the Batavian revolt.
Espacio, Desastre y Renta: La (re) producción de Coapa como destrucción creativa
Authors: Saracho López Federico , González Luna Fabián
Published: September 2020

El presente artículo discute la forma en que los desastres, además de ser una manifestación cruda y directa de la desigualdad estructural como condición de desarrollo de la lógica capitalista, se constituyen como una estrategia de acumulación mediante la generación e intensificación de rentas diferenciales, que también refuerzan y mantienen la condición de clase. Los desastres son un mecanismo muy efectivo de ordenación de la vida social a través del acceso desigual al espacio como medio de reproducción. Al utilizar como ejemplo el caso de Coapa en relación con el sismo del 19 de septiembre de 2017, busca discutir las formas sistémicas y estructurales en las que vertemos nuestros esfuerzos para “hacer ciudad”, fundamentadas en la subordinación del mundo de la vida a la realización y reproducción del mercado. También pretende ilustrar diferentes estrategias espacio-temporales de acumulación, que coadyuven a crear y fijar condiciones de rentabilidad diferenciadas, las cuales se hacen más presentes en torno al desastre y la tragedia.
Percepción y desplazamiento en el espacio híbrido con realidad mixta
Authors: Palomo Beltrán Clementina
Published: September 2020

El objetivo de esta investigación fue evaluar el impacto de la tecnología RM en la percepción del usuario dentro del espacio arquitectónico. Participaron 35 informantes. Se realizó una prueba real (croquis y plano arquitectónico) + CAVE + CAVE + espacio real, y una prueba real plano arquitectónico espacio real + MAGIC LEAP. La aplicación de la tecnología RM en el espacio arquitectónico impacta positivamente en la percepción del usuario de los conceptos de distancia, profundidad y permisividad de movimiento dentro del espacio virtual y físico que modifica la transición entre espacios arquitectónicos. No se encontraron diferencias estadísticamente significativas en cuanto a la eficiencia en función del tiempo empleado y el número de consultas realizadas. Sería necesario hacer adaptaciones de la RM en lo visual, auditivo y cinestésico y estudiar su efectividad en el espacio arquitectónico.
Sobre Xavier Cortés Rocha “Architectura Mechanica / La profesión y el oficio”, 2019, ISBN: 978-607-30-2604-8
Authors: Cejudo Collera Mónica
Published: September 2020

En este trabajo se hace una aproximación crítica al libro de Xavier Cortés Rocha “Architectura Mechanica / La profesión y el oficio”, 2019, ISBN: 978-607-30-2604-8
Implementation of two robotic flagmen controlled by CAN messages to increase the safety of human workers in road maintenance
Authors: Flores David Lopez , Alonso Graciela Ramirez , Prieto Daniel Aguirre , Corral Martin Acosta , Camargo Arturo Armendariz , Perez Brian Granados
Published: September 2020

Commonly, the improper signaling in road construction zones is the cause of different accidents to drivers, pedestrians, and road construction workers. The signaling used when a vehicle is approaching a repairing section could be classified into two classes: stationary or active. Nevertheless, active warning systems have demonstrated to reduce accidents in road work zones. Within the active signaling class we have: portable changeable message sign, flashing arrow signs, flagman, to mention some. This paper describes the implementation of two robotic flagmen controlled by the Controller Area Network (CAN) protocol. Each robotic flagman can perform four different actions: speed reduction (right and left) and lane change (right and left). The electronic circuitry and mechanical motors of the two robotic flagmen have the option to be powered by a solar charging system considering working zones where there is no access to the electric grid. The solar charging system guarantees a sufficient electrical power supply for night conditions operations. Also, the CAN protocol can be used to monitor the correct operability of the robotic flagmen thus eliminating the need to incorporate more expensive electronic devices such as cameras. The hardware combination in the control, monitoring, and solar charging system allow us to propose a low-cost practical implementation. The results of our implementation show that the longest response time of the robot is less than 850 ms once that the CAN message has been sent to the network. This demonstrates that our proposal can meet real-time implementation requirements.
La tesis y la formación en investigación: significados construidos por estudiantes de pedagogía
Authors: Landín Miranda María del Rosario , Juárez Rojas Nohemí Guadalupe
Published: September 2020

La formación en Investigación Educativa es un aspecto fundamental en la Licenciatura en Pedagogía de la Universidad como se enuncia en la introducción, Universidad Veracruzana, México, en congruencia con la política educativa a nivel nacional. En ese contexto, se desarrolló un estudio cualitativo a través de entrevistas a profundidad a 8 estudiantes universitarios. La metodología de las comparaciones constantes y el programa Atlas Ti, permitieron integrar categorías con el fin de explorar aquellos significados que han construido sobre la formación en investigación educativa y la tesis. El estudio permitió conocer cómo el contenido de los significados es el producto de la interacción que los estudiantes establecen con sus iguales y los profesores, con el currículum, el contexto escolar y social. En conclusión, la formación en investigación educativa requiere formar parte del desarrollo curricular; ser vista como experiencia, donde profesor y estudiante se impliquen en la búsqueda incesante de la pregunta, en la aventura por conocer.
Interparental conflict, parent–adolescent attachment, and adolescent Internet addiction: The moderating role of adolescent self-control
Authors: Wei Chang , Chen Pei , Xin Mucheng , Liu Hui , Yu Chengfu , Zou Qiang
Published: September 2020

We explored the extent to which adolescent self-control moderated the relationships among interparental conflict, parent–adolescent attachment, and adolescent Internet addiction. Participants comprised 459 junior high school students, who completed the Adolescents' Perception
of Interparental Conflict Scale, the Self-Control Scale, the Inventory of Parent and Peer Attachment, and the Internet Addiction Scale. Results show that adolescents' perceptions of interparental conflict was significantly and positively correlated with their Internet addiction. In addition,
the relationship between perceived interparental conflict and Internet addiction was mediated by parent–adolescent attachment. Finally, self-control moderated the relationships among interparental conflict, parent–adolescent attachment, and Internet addiction. Policy implications,
limitations, and directions for future research are discussed.
EXPLORING THE ANTIPARASITIC ACTIVITY OF MEDICINAL PLANTS
Authors: Raoof Gehan Fawzy Abdel , Mohamed Ahmed Wael Lethy
Published: September 2020

Parasitic disease is one of the most important challenges impacting a large number of people. Worldwide, more than three billion cases of parasitic disease are reported yearly. Due to the resistance of parasite to the synthetic drugs, it is necessary to search for alternative sources. Plants contain different phytoconstituents with different biological activities.  Many previous researches showed that many plants exerted antiparasitic activity due to its secondary metabolites. This review highlights the antiparasitic effects of different medicinal plants and mentions the mode of action of different phytochemicals against parasites. In conclusion, the medicinal plants play a vital role as antiparasitic agents, but further studies are needed to isolate and test the active constituents of the medicinal plants as antiparasitic agents targeting to enter the drug discoveryarea. 
Peer Review History:
Received 20 July 2020; Revised 11 August; Accepted 26 August, Available online 15 September 2020
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Received file

Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewer(s) detail:
Name: Marwa  A. A. Fayed
Affiliation: Faculty of Pharmacy, University of Sadat City, Egypt
E-mail: maafayed@gmail.com
 
Name: Dr. Mahmut Yıldıztekin
Affiliation: Muğla Sıtkı Koçman University, Turkey
E-mail: mahmutyildiztekin@mu.edu.tr
 
Comments of reviewer(s):

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Carlos Camacho, Margarita Garrido y Daniel Gutiérrez (eds.). Paz en la República. Colombia, siglo XIX. Bogotá: Universidad Externado de Colombia, 2018, 334 pp.
Authors: Cardozo Ruidiaz Manuel Faustino
Published: September 2020

Mucho se ha escrito sobre la guerra y sobre la violencia en Colombia. Al punto que los dedicados a estos complejos tópicos se han hecho merecedores del mote académico de “violentólogos”. No obstante, no existía hasta ahora un libro de tipo histórico que definiera el concepto de paz para un periodo específico y estableciera pautas de análisis en torno a un estado de convivencia social, tolerancia de la diferencia ideológica, política y ausencia de enfrentamiento bélico. He allí la importancia académica y social del texto que ocupa esta reseña. El cual fue editado por Margarita Garrido Otoya, Carlos Camacho Arango y Daniel Gutierrez Ardila y publicado por la universidad externado de Colombia en diciembre de 2018.
El libro es un conjunto de siete ensayos de autores expertos en temas variados, relativos a la construcción y operación del Estado y las formas históricas de construcción de lo que hoy conocemos como Colombia.
Betancourt, Alexander. América Latina: cultura letrada y escritura de la historia. Barcelona: Anthropos Editorial, Universidad Autónoma de San Luis Potosí, México, 2018
Authors: Camargo Jhoan Manuel
Published: September 2020

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El liberalismo de Ignacio V. Espinosa
Authors: Cataño Molina Gonzalo
Published: September 2020

En un pasaje del Plan agrícola, libro de Luis Ospina Vásquez poco frecuentado por los investigadores, el analista de la economía nacional registró la pobreza del pensamiento político colombiano. Para ilustrarlo, aludió de pasada al autor de las Bases positivas del liberalismo, afirmando que, dado el febril entusiasmo por lo nacional, quizá un historiador del futuro opte por exaltar “el pequeño catecismo positivista de Ignacio V. Espinosa, como una exposición de las ideas de la corriente positivista de nuestro país, fruto de largas cavilaciones...”. Encontraba el texto liviano, ligero y pobre a pesar de que en su libro mayor Industria y protección en Colombia lo había usado para ilustrar las afinidades de la ideología liberal con las políticas librecambistas.
Espinosa no fue, en verdad, un pensador original. Sus amigos, colegas y estudiantes lo exaltaron, pero en ello siempre hubo más cariño y devoción por la persona que reflexión sobre sus logros intelectuales. Fue un divulgador piadoso y poco docto del legado de Herbert Spencer en el salón de clase y en las planas de periódicos y revistas. Murió joven y muy joven publicó sus trabajos. Se lo recuerda en los anales nacionales de la Colombia fin de siècle por su tesis de grado El matrimonio (1889), por la Filosofía experimental, extracto de las doctrinas psicológicas de Herbert Spencer (1891), por su conferencia El positivismo (1893) y por las Bases positivas del liberalismo (1895), su libro más representativo. A ellos se deben sumar, La reorganización (1898), un complemento de las Bases dirigido a llamar la atención sobre los peligros de la dirección despótica (personalista) de los partidos políticos, y la útil Jurisprudencia de la Corte Suprema de Justicia de 1896, redactada en compañía del jurista Juan B. Quintero C. —futuro profesor de Derecho Civil y de Práctica Forense del Externado—, que registra las innovaciones de la casación. Y no solo esto. Un compañero de estudios del Rosario, Ambrosio Robayo, recordó en una ocasión la existencia de un folleto de crítica literaria, de una Ética que no alcanzó a publicar y de un panfleto sobre El fetiquismo, colombianismo que se usaba en la época para señalar los peligros de la veneración excesiva, fetichista, de una creencia. Hasta el momento no se ha encontrado rastro alguno de estos textos.
Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans
Authors: Sharma Neeraj K. , Comeau Mary E. , Montoya Dennis , Pellegrini Matteo , Howard Timothy D. , Langefeld Carl D. , Das Swapan K.
Published: September 2020

Decline in insulin sensitivity due to dysfunction of adipose tissue (AT) is one of the earliest pathogenic events in type 2 diabetes. We hypothesize that differential DNA methylation (DNAm) controls insulin sensitivity and obesity by modulating transcript expression in AT. Integrating AT DNAm profiles with transcript profile data measured in a cohort of 230 African Americans (AAs) from the African American Genetics of Metabolism and Expression cohort, we performed cis-expression quantitative trait methylation (cis-eQTM) analysis to identify epigenetic regulatory loci for glucometabolic trait–associated transcripts. We identified significantly associated cytosine-guanine dinucleotide regions for 82 transcripts (false discovery rate [FDR]-P < 0.05). The strongest eQTM locus was observed for the proopiomelanocortin (POMC; ρ = −0.632, P = 4.70 × 10−27) gene. Epigenome-wide association studies (EWAS) further identified 155, 46, and 168 cytosine-guanine dinucleotide regions associated (FDR-P < 0.05) with the Matsuda index, SI, and BMI, respectively. Intersection of EWAS, transcript level to trait association, and eQTM results, followed by causal inference test identified significant eQTM loci for 23 genes that were also associated with Matsuda index, SI, and/or BMI in EWAS. These associated genes include FERMT3, ITGAM, ITGAX, and POMC. In summary, applying an integrative multiomics approach, our study provides evidence for DNAm-mediated regulation of gene expression at both previously identified and novel loci for many key AT transcripts influencing insulin resistance and obesity.
Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis
Authors: Martchenko Sarah E. , Martchenko Alexandre , Cox Brian J. , Naismith Kendra , Waller Alison , Gurges Patrick , Sweeney Maegan E. , Philpott Dana J. , Brubaker Patricia L.
Published: September 2020

The incretin glucagon-like peptide 1 (GLP-1) is secreted by the intestinal L cell upon nutrient ingestion. GLP-1 also exhibits a circadian rhythm, with highest release at the onset of the feeding period. Similarly, microbial composition and function exhibit circadian rhythmicity with fasting-feeding. The circadian pattern of GLP-1 release was found to be dependent on the oral route of glucose administration and was necessary for the rhythmic release of insulin and diurnal glycemic control in normal male and female mice. In mice fed a Western (high-fat/high-sucrose) diet for 16 weeks, GLP-1 secretion was markedly increased but arrhythmic over the 24-h day, whereas levels of the other incretin, glucose-dependent insulinotropic polypeptide, were not as profoundly affected. Furthermore, the changes in GLP-1 secretion were shown to be essential for the maintenance of normoglycemia in this obesogenic environment. Analysis of the primary L-cell transcriptome, as well as of the intestinal microbiome, also demonstrated time-of-day– and diet-dependent changes paralleling GLP-1 secretion. Finally, studies in antibiotic-induced microbial depleted and in germ-free mice with and without fecal microbial transfer, provided evidence for a role of the microbiome in diurnal GLP-1 release. In combination, these findings establish a key role for microbiome-dependent circadian GLP-1 secretion in the maintenance of 24-h metabolic homeostasis.