bluuebunny/crossref_metadata_2025 huggingface dataset:
Kaempferol Protects Against Streptozotocin-Induced Diabetic Cardiomyopathy in Rats by Inhibition of the NLRP3/Caspase-1 Signaling Pathway
Authors: Shen An-lu , Du Yong-qin , Ye Min , Zhou Lan , Ding Hui-min , Hu Zi-qing , Zhou Peng
Published: December 2024

Kaempferol (KPF) attenuates diabetic cardiomyopathy (DCM) in streptozotocin (STZ)-treated rats through its hypoglycaemic and insulin-releasing effects, however, the mechanism of KPF protects against DCM is unclear. This study was to reveal the cardioprotective mechanism of KPF. Molecular docking was used to predict the target of KPF. STZ-induced diabetes mellitus (DM) rats was established. The model rats with successful modeling were randomly divided into DM group, KPF group (10 mg/kg), and metformin (Met) group (120 mg/kg). The CTL group and DM group were gavaged with equal amounts of CMC-Na, and all groups were intervened for eight weeks. The changes of blood glucose in different groups was detected. Hematoxylin-eosin (HE), and Masson staining were used to assess pathological changes. Creatine kinase (CK), and B-type natriuretic peptides (BNP) levels were examined. RT-qPCR was used to detect the mRNA expression levels of toll-like receptor 4 (TLR4), NOD-like receptor protein 3 (NLRP3), cysteinyl aspartate specific proteinase-1 (Caspase-1), and GSDMD-N-terminal domain (GSDMD-N), and Western blot was used to detect the expression of NLRP3, and GSDMD-N. KPF has a good binding affinity with TLR4. KPF could significantly improve the abnormal elevation of blood glucose, mitigate pathological changes, and reduce CK and BNP levels. Further mechanistic studies found that KPF reduced the mRNA expressions of TLR4, NLRP3, Caspase-1, and GSDMD-N, and decreased the protein expressions of NLRP3, and GSDMD-N. In conclusion, the mechanism of KPF protects against DCM is related to the inhibition of the NLRP3/Caspase-1 signaling pathway, providing a novel mechanism for KPF intervention in DCM.
Comment on ”Exploring potential energy surfaces to reach saddle points above convex regions” [J. Chem. Phys. 160, 232501 (2024)] by M.Gunde et al.
Authors: Quapp Wolfgang , Maria Bofill Josep
Published: December 2024

We comment on the work on convex regions of the potential energy surface (PES) of a molecule by M. Gunde; A. Jay; M. Poberžnik; N. Salles; N. Richard; G. Landa; N. Mousseau; L. Martin-Samos and A. Hemeryck[1]. In contrast to the activation-relaxation technique nouveau (ARTn), in the present work we apply the theory of Newton trajectories (NTs) to the 2D PES. NTs have no problem traversing convex or concave regions of the PES. The ARTn is compared with NTs.
Melitta seitzi Alfken, 1927, une nouvelle mélitte pour la faune française (Hymenoptera, Melittidae)
Authors: Aubert Matthieu , Leclercq Vincent
Published: December 2024

Melitta seitzi Alfken, 1927, a new melittid bee to the French fauna (Hymenoptera, Melittidae).
Melitta seitzi (Melittidae), a bee species previously known only in Spain, was found in 2022 in southeast France as part of a project to improve knowledge of wild pollinators in the Parc Naturel Régional du Verdon. Additional surveys carried out in 2023 revealed that the females forage locally on the flowers of Lotus dorycnium L. (Fabaceae). An analysis of the bee assemblages observed at the same time as M. seitzi leads us to suspect a possible association of M. seitzi with some cuckoo-bees of the genus Nomada. The article also proposes an identification key to distinguish M. seitzi from the other species of the genus present in France. This key is accompanied by a comparative table.
Enhancement of Solubility and Formulation of Fast Dissolving Oral Films of an Antiemetic Drug
Authors: Tiwari Snehil , Lariya Deepali , Dubey B. K. , Basedia Deepak Kumar
Published: December 2024

This study investigates the development of a fast-dissolving oral film formulation (F3) for efficient delivery of Astemizole, an antiemetic drug. The formulation incorporates solubility enhancers, PEG 400 and PVP K-90, to improve the solubility and bioavailability of the drug. The solubility enhancement study revealed significant improvements, especially at higher concentrations, ensuring rapid dissolution and enhancing therapeutic efficacy. The drug content analysis of formulation F3 demonstrated 98.50% of the label claim, indicating high uniformity and reliable dosing. Further characterization of formulation F3 showed superior folding endurance (235 folds), the fastest disintegration time (63 minutes), and a high assay value (99.12%), reflecting excellent mechanical properties and rapid drug release. The in-vitro release study revealed nearly complete drug dissolution (98.85%) within 15 minutes, making the formulation ideal for drugs requiring a rapid onset of action. Stability studies over three months confirmed the formulation's minimal degradation and stable drug content (98.32%). In conclusion, formulation F3 is a promising candidate for fast-dissolving oral films, with excellent drug release, stability, and consistency. Further clinical trials and stability assessments are recommended to validate its efficacy and optimize its clinical application.

Keywords:Fast-dissolving oral film, Astemizole, Solubility enhancement, PEG 400, PVP K-90, Bioavailability, Drug content analysis, Folding endurance, Disintegration time, In-vitro release, Stability studies, Patient compliance, Pharmaceutical formulations.
НАЦІОНАЛЬНА ІДЕНТИЧНІСТЬ В УМОВАХ ЕКЗИСТЕНЦІЙНОЇ ЗАГРОЗИ
Authors: Завгородня Олена Василівна
Published: December 2024

У статті окреслено особливості формування національної ідентичності в умовах екзистенційної загрози. Переживаючи досвід різних форм національної солідарності, люди засвоюють спільні переконання, що лежать в основі національної ідентичності. Переконання розглядаються як уявлення про світ, які вважаються істинними, незалежно від того, чи підтверджено це об’єктивно. Переконання національного рівня можна розглядати як спільні уявлення співвітчизників, ціннісно й емоційно значущі для них, які стосуються важливих для них тем і проблем, а також сприяють позитивній самооцінці та відчуттю власної унікальності членів національної спільноти. Трансформацію переконань спричинюють масштабні події, зокрема загрозливі. Зміна глибоко вкорінених спільних переконань передбачає зміну значень й сенсів національної ідентичності. Зміни спільних переконань відбуваються впродовж тривалого часу. Навіть коли відбуваються події, пов’язані зі стрімкою зміною безпекових умов, з загостренням чи пом’якшенням національних загроз – початок війни чи встановлення тривалого миру, спільні переконання змінюються поступово. Загрози для країни можуть бути зовнішні, внутрішні, глобальні. Екзистенційною для країни є загроза, яка проблематизує саме її існування як держави, відповідно, й пов’язаної з нею національної ідентичності. Стверджується, що спільні переконання та національна ідентичність можуть бути різною мірою мілітаризованою; це виявляється в комплексі переконань та почуттів. Наприклад, якщо країна переживає значну військову загрозу, то в ній формується комплекс переконань вимушеного мілітаризму. В умовах екзистенційної загрози зазначені переконання представлено в свідомості громадян, також вони транслюються у системі освіти в процесі формування національної ідентичності школярів. Наводяться історичні і сучасні приклади.
Tras la huella del ñandú
Authors: Salazar López Pablo
Published: December 2024

El autor teje estas narraciones con alusiones y citas de algunas de sus lecturas, con recuerdos de vida y muchas notas de cultura general que detonan su creatividad. Parece mostrarnos el camino intelectual y biográfico que lo llevó a construir estas historias: el encuentro con una mujer durante un viaje por Europa, propiciado por el tema del suicidio; un ave que parece llegar al departamento del narrador con la finalidad de apartarse de la parvada para morir, a manera de suicidio; un hombre que observa lo que sucede en su entorno e imagina qué hacen sus vecinos tras puertas y ventanas; una serie de vivencias en la ciudad de origen, Tuxtla Gutiérrez, Chiapas, va surgiendo a raíz de un pasaje literario que narra cómo un ñandú roba una piedra verde a un comensal en un café y el mesero le asegura que el ave la devolverá al día siguiente pues el ñandú siempre regresa lo que se lleva; un relato inspirado en un mítico café de Berlín durante la estancia con beca de escritor en esa ciudad; la astucia de Fidel Castro para evitar los besos de sus colegas rusos; finalmente, una composición tripartita sobre el gusto por las nueces de Brasil, el aroma de las flores del castaño y la planta de espino, y una anécdota romántica con una chica polaca sensible a la relación entre lengua y dominación política.
Comparative Genomic Analysis of an Apiotrichum cacaoliposimilis Strain Isolated from a Patient with Urinary Tract Infection
Authors: Wang Wei , Yi Jinping , Zhan Jiahuan , Luo Dong , Chen Qiang , Yu Shengming , Xie Ling , Chen Kaisen
Published: December 2024

Opportunistic infections caused by fungi, particularly those occurring in immunocompromised patients, are considered challenging worldwide. Therefore, a comprehensive understanding of pathogenic fungi is necessary. The present study reports the isolation of a strain of Apiotrichum cacaoliposimilis, which is difficult to detect using conventional clinical assays, from the sterile urine samples of a patient with a urinary tract infection. Sanger sequencing of the internal transcribed spacer regions confirmed the genus of the microbe, while whole-genome sequencing yielded the initial genome assembly of A. cacaoliposimilis. A total of 7,161 predicted proteincoding genes were mapped using multiple databases, including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, non-redundant protein database, Pathogen-Host Interactions Database, and Comprehensive Antibiotic Resistance Database. The phenotypic data, biochemical reactions, and antimicrobial susceptibility analyses were conducted to reveal the metabolic properties, virulence, and drug resistance profile of the isolated A. cacaoliposimilis. The rank-sum test revealed the differences in the intergeneric distribution of the highly virulent genes UgeB and Pem2. In addition, other genes exhibited significant overlap in terms of virulence factors with the clinical isolate Apiotrichum mycotoxinivorans GMU1709. Fortunately, similar to most fungi belonging to the Apiotrichum genus, the isolate investigated in the present study was also sensitive to the drug voriconazole (MIC = 0.06 μg/ml). In summary, the phylogenetic placement, potential pathogenic genes, drug sensitivity patterns, and morphological characteristics of the isolated A. cacaoliposimilis were determined precisely in the present study.
Pemanfaatan Limbah Sisik Ikan Nila dan Ikan Kakap Merah sebagai Kitosan
Authors: Utami Risnita Tri , Elvina Wica , Pardiansyah Dedi , Yulfiperius Yulfiperius
Published: December 2024

Fish scales are leftover fishery products that are not utilized optimally. Fish scales contain chemical compounds such as organic protein, namely chitin, which is a derivative of chitosan. Chitosan can be used in various sectors such as the food industry, health, agricultural and cosmetics. This study aims to extract chitosan from the scales of farmed and marine fish, as well as to determine the ratio of the yield of chitosan to types of marine fish and cultivated fish. This research was conducted from July to August 2023. The fish scale samples used were tilapia (cultivated fish) and snapper (sea-caught fish) obtained from the Traditional Market and Fish Auction Place in Bengkulu City. The process of making chitosan is carried out in the Laboratory of the Faculty of Agriculture, Prof. Dr. Hazairin, SH University. The process of extracting chitosan from fish scales goes through three stages, namely deproteination, demineralization and deacetylation. The results showed that the water, ash and protein content of fish scales were different, namely tilapia (19.05%; 20.15%; 53.01%) and snapper. (10.78%; 43.54%; 28.49). Results of Tilapia Chitosan. (13.22%) and snapper (7.74%). Several chitosan characteristics such as color, shape and odor meet commercial chitosan standards.
Pengaruh Kombinasi Bungkil Sawit Terfermentasi Dengan Natura Organik Dekomposer dan Ampas Tahu Terhadap Laju Pertumbuhan Maggot BSF (Hermetia illucens )
Authors: Christiana Ivone , Maryani Maryani , Rozik Mohamad , Matling Matling , Lumbantoruan Yosua
Published: December 2024

BSF maggots (Hermetia illucens) also have quite high nutritional content, making BSF maggots able to be used as feed for fish. Maggot BSF works to convert organic waste into simpler biomass. Organic waste from agricultural waste is a medium for maggot enlargement that can be used as feed. Agricultural organic waste in Indonesia is available in quite large quantities. The types of waste that can be used as cultivation media are tofu waste and palm oil cake waste.Â  This study aims to determine the effect of the combination of fermented palm oil cake with natural organic decomposer and tofu waste on the growth rate of Maggot BSF (Hermetia illucens). The method used in this research is the experimental method using Completely Randomized Design (CRD). The factors studied were the combination of fermented palm oil cake with natural organic decomposer and tofu waste on the growth of Maggot BSF which consisted of 4 treatment levels, namely A (100% fermented palm oil cake); B (75% fermented palm oil + 25% tofu dregs); C (50% fermented palm oil + 50% tofu dregs); D (25% fermented palm oil + 75% tofu waste). Parameters observed were BSF maggot length and weight growth, digested feed conversion efficiency (ECD), waste reduction index (WRI), BSF maggot productivity.Â  Data used is Analysis of Variance (ANOVA) and to determine the best treatment using a follow-up test in the form of Duncan's test with a significance level of 5%. The results showed that the combination of fermented palm oil cake with different natural organic decomposers and tofu dregs had a significant effect on the productivity of BSF maggots. The best combination of fermented palm oil cake with natural organic decomposer and tofu waste on the growth rate of Maggot BSF is 100% fermented palm oil cake which has a significant effect when compared to other treatments.
Identifikasi Ektoparasit Pada Ikan Lele Dumbo (Clarias gariepinus) Yang Di Budidayakan di Kolam Beton
Authors: Welnando Rydho , Maryani Maryani , Tantulo Uras , Rozik Mohamad
Published: December 2024

There are several obstacles for dumbo catfish farmers that result in losses, one of which is disease.  Diseases caused by parasitic infections can cause irritation to external organs such as gills and skin. This can cause disruption of respiration and osmoregulation processes and reduce fish immunity.   The population of ectoparasites in fish in the aquatic environment can be monitored through the identification of parasites by calculating their prevalence and intensity.  This study aims to identify ectoparasites, analyze the prevalence rate, intensity of ectoparasite attacks that attack dumbo catfish.  Sampling for 5 times in one week for 20 working days with the number of samples to be obtained as much as the catch of 3 stations.  Ectoparasites found in dumbo catfish are Dactylogyrus sp, Trichodina sp, Chilodonella sp, and Oodinium sp. The highest prevalence value was found in Dactylogyrus sp at station III with a percentage of 100% with a very frequent infection category. The highest intensity value was Trichodina sp. at station II which was 24.4 individuals/head with moderate category. The dominating ectoparasite was Dactylogyrus sp. The number of infected dumbo catfish was 30 out of 30 samples tested.  In Dactylogyrus sp there were a total of 258 parasites, followed by Chilodonella sp with a total of 69 parasites from 30 samples, Oodinium sp had a total of 47 parasites and Trichodina sp had a total of 151 parasites from 30 samples.  Water quality parameters measured during the study showed good values for the growth of dumbo catfish in the rearing ponds.
Application Of Zeolit And Activated Carbon On Transportation Of Fish Seed (Leptobarbus Hoeveniii Blkr) With Different Densities
Authors: Pratama Wahyu , Harianto Eko , Arifin M Yusuf , Pangentasari Dwinda
Published: December 2024

. This study aims to determine the optimum density and to analyze the effectiveness of zeolite and activated carbon additives in the transportation of jelawat fish seed 2-inch for 12 hours. This research was conducted in March-May 2023. Transportation was carried out for 12 hours with the mode of transportation being a 4-wheeled minibus with travel routes starting from Jambi City to West Tanjung Jabung Regency. The experimental design used was a Completely Randomized Design (CRD) with 4 (four) treatments and 3 (three) replications, the treatments given were densities including: treatment A density of 100 individuals/container, treatment B density of 200 individuals/container, treatment C density 300 individuals/container and treatment D at a density of 400 individuals/container. In each container, 20 g and 10 g of zeolite and activated carbon were added. After being transported, the fish were maintained for 14 days. The results showed that during the transportation there were no fish deaths in all treatments so that the survival rate in all treatments was 100%. The average blood glucose level before transportation ranged from 56.3 – 57.3 mg/dL. The survival rate of post-transported barnet fish fry on day 0 to day 7 was 100%, while on day 14 the survival rate ranged from 90.1% -92.3%. Absolute length growth ranged from 1.30 cm/head – 1.38 cm/head. Absolute weight growth ranged from 0.30 gram/head-0.32 gram/head. Blood glucose levels at the start of maintenance ranged from 62.0-87.0 mg/dL. On the 14th day it ranged from 38.3 mg/dL-48.7 mg/dL. The water quality during the transportation and rearing process is still in the optimal range for barley fingerlings
Intensitas Serangan Jamur Ganoderma sp Pada Perkebunan Kelapa Sawit Lahan Mineral dan Lahan Pasang Surut
Authors: Rahmana Billy Aditia , Hayata Hayata , Hartawan Rudi
Published: December 2024

Stem rot disease caused by fungus (Ganoderma sp)  is a major challenge in oil palm farming. This fungus infects oil palm trees at every stage of growth. This disease has a gradualy development, which the symptoms only appearing in the last stages, so it is called as "silent killer" of oil palm trees. This study aims to determine the attacks intensity of Ganoderma sp fungus on oil palms planted in mineral land and tidal land. This research was conducted on mineral land in Suko Awin Jaya Village, Muaro Jambi Regency and tidal land in Petanang Kumpeh Village. This research was conducted in May - July 2024. The research was conducted under unformatted trial design. The research location was purposive chosen for there were relatively uniform plants in that location, and the Ganoderma sp attacks were found in that place namely:1. Mineral land, 2. Tidal land.  There were 2 sampling sites, in two different land, with an area of 1 Ha, which were randomly selected from 5 hectares of existing plants. Census sampling method was used to determination the trees as a sample at the research location so sample totaly were 135 trees. The results of this study showed that on mineral land the attacks percentation  was 2.61% and the attacks intensity  was 1.99% higher than the attacks percentation and attacks intensity on tidal land representative 1.50% and  1.13%.
Prevalensi Varian Normal Lidah pada Lansia di Panti Tresna Werdha Budi Mulia 1
Authors: Nurfianti Nurfianti , Wulandari Amalia Rafa , Audiawati Audiawati , Ronal Ahmad
Published: December 2024

Pendahuluan: Penuaan adalah proses fisiologis yang ireversibel, yang sangat berperan dalam memodifikasi banyak jalur biologis yang dapat meningkatkan risiko pengembangan kondisi patologis spesifik usia atau memodifikasi epidemiologi patologi lain yang biasa terjadi pada orang yang lebih muda. Penuaan mempengaruhi struktur rongga mulut. Tujuan: Penelitian ini bertujuan untuk mengetahui prevalensi varian normal lidah, mengetahui gambaran varian snormal lidah pada lansia di Panti Tresna Werdha Budi Mulia 1. Metode: Penelitian ini dilakukan pada bulan November 2023 dengan metode studi deskriptif dengan desain cross-sectional dengan pengambilan sample secara purposive sampling. Hasil: Prevalensi varian normal lidah pada penelitian ini adalah fissured tongue (74,5%), coated tongue (36,2%), varikositas lingualis (38,3%), pigmentasi fisiologis (22,3%) , geographic tongue (2,1%), crenated tongue (14,9%). Kesimpulan: Prevalensi paling banyak dalam penelitian ini adalah fissured tongue, serta lebih dari 50% memilki lebih dari 2 varian normal lidah, adanya hubungan penurunan fungsi tubuh pada lansia.
ЗАГАЛЬНІ ПІДХОДИ ДО ОЦІНЮВАННЯ ЕФЕКТИВНОСТІ ПРОТИПОВІТРЯНОЇ ОБОРОНИ З УРАХУВАННЯМ ЗАСТОСУВАННЯ FPV-ДРОНІВ-ПЕРЕХОПЛЮВАЧІВ
Authors: Печененко Олег , Ярошенко Ярослав , Блискун Олександр
Published: December 2024

У статті розглядаються новітні підходи до інтеграції FPV-дронів-перехоплювачів до системи протиповітряної оборони, як окремої підсистеми, особливо в контексті сучасної війни, яка вимагає високої оперативності реагування на загрози з повітря та високої ефективності їх ураження. Проблема підвищення оперативної готовності та точності дій винищувальної авіації стає особливо актуальною в сучасних умовах ведення бойових дій, де час реакції на загрозу визначає успішність виконання завдання. За останні роки застосування FPV-дронів, які можуть перехоплювати ворожі безпілотні літальні апарати революціонізувало підхід до протидії загрозам у повітрі. У статті розглянуто спосіб підвищення ефективності протиповітряної оборони шляхом спільного застосування FPV-дронів і винищувальної авіації, що дозволяє суттєво підвищити швидкість реагування на загрози та підвищити ефективність ураження повітряних цілей. Результати досліджень показують, що інтеграція дронів-перехоплювачів у систему протиповітряної оборони дозволяє суттєво знизити час реакції, підвищує ефективність ураження цілей та оптимізує розподіл ресурсів. Стаття може бути корисною для фахівців з військових технологій, дослідників у сфері протиповітряної оборони та операторів безпілотних літальних апаратів.
ROSSINI-Platform - Reduction of surgical site infection with a platform trial utilising a 'Basket-MAMS' design - Application acceleration award
Authors:   The ROSSINI-Platform Investigators Collaborating Group*
Published: December 2024

Background Surgical site infection (SSI) is the most common surgical complication, resulting in significant morbidity, mortality, and major costs to health service providers. Multi-arm, multi-stage (MAMS) trials allow multiple individual interventions to be evaluated simultaneously, rendering them highly efficient at both speed and cost. Our group is running the successful ROSSINI 2 MAMS trial in abdominal SSI reduction, which was funded by HTA and proved that such trials are deliverable and effective in a modern surgical context. Our proposed platform study will run multiple parallel RCTs in different surgical cohorts, utilising a ‘Basket-MAMS’ design to simultaneously assess multiple interventions and will share learning between cohorts to take successful arms from one area to another for rapid testing. This would provide robust and context-specific evidence for rapidly improving patient care. Methods We identified a list of key methodological, logistical, health economic, PPI-related, and clinical design challenges. A large study team was assembled, consisting of both core experts and national clinical research leaders, including robust plans for capacity building, Chief Investigator (CI) development, and multi-level PPI engagement. The working groups designed a series of parallel work packages to address the identified challenges, both centrally and in clinical networks, convening regularly to discuss and plan the full application. Iterative modifications and improvements to the overall proposal were allowed and encouraged. Results We report the progress, activities undertaken, and decisions made throughout the application acceleration award project. This information may be beneficial to planning or preparing a similar large-scale and multi-specialty platform trial. Conclusions The acceleration grant allowed us to design a fundable and deliverable clinical trial for the HTA platform trial call in late 2023. The full trial has the potential to significantly impact the rates of this highly impactful complication, thereby benefitting both patients and health services worldwide.
Thermal Radiation Effects on Entropy Generation in Porous Media with Casson Fluid via FEM Insights
Authors:   College of Civil and Transportation Engineering, Shenzhen University, Shenzhen, 518060, China, Talib Shaiza , Mbye Cham Bai ,   Department of Mathematics, University of The Gambia, P.O. Box 3530, Serrekunda, The Gambia, Charreh Dawda ,   Department of Mathematics, COMSATS University Islamabad, Islamabad Campus, Park Road, Tarlai Kalan, Islamabad 45550, Pakistan, Marong Bakary L. ,   Department of Mathematics, University of The Gambia, P.O. Box 3530, Serrekunda, The Gambia
Published: December 2024

This paper offers a detailed examination of entropy generation within a porous medium that is saturated with Casson fluid during
the process of natural convection. The governing equations comprising momentum, energy, and entropy are solved numerically
using the finite element method. The research explores various significant parameters, including the Casson fluid parameter,
thermal radiation, Rayleigh number, and Prandtl number, to evaluate their effects on entropy generation. Findings indicate
that the Darcy and Rayleigh numbers primarily dictate the strength of natural convection, while the Casson fluid parameter
has a considerable impact on both flow dynamics and heat transfer characteristics. This analysis delivers essential insights
for optimizing flow and thermal behaviors in systems utilizing Casson fluids. Furthermore, the Prandtl number highlights the
significance of heat transport relative to viscous effects. A near thermal stratification is observed at β=0.001, and the isotherms
undergo substantial changes as temperature gradients increase to β = 1. The average Nusselt number and total entropy are
influenced by the temperature distribution, with a consistent flow pattern emerging over time. As the Rayleigh number in the flow
configuration rises, the velocity decreases, leading to the emergence of uniform flow phenomena.
1
College of Civil and Transportation Engineering,
Shenzhen University, Shenzhen, 518060, China
2
Institution of Urban Smart Transportation & Safety
Maintenance College of Civil and Transportation
Engineering, Shenzhen University, Shenzhen, China
3
Department of Mathematics, University of The
Gambia, P.O. Box 3530, Serrekunda, The Gambia
4
Department of Mathematics, COMSATS University
Islamabad, Islamabad Campus, Park Road, Tarlai
Kalan, Islamabad 45550, Pakistan
Keywords: Casson Fluid, Entropy Generation, Heat Transfer, Porous Medium, Finite Element Method, N
ОСОБЛИВОСТІ ҐЕНЕЗИ ТРИВОЖНОСТІ ПІДЛІТКІВ ІЗ ТЯЖКИМИ ПОРУШЕННЯМИ МОВЛЕННЯ В УМОВАХ КРИЗОВИХ ВИКЛИКІВ СУЧАСНОСТІ
Authors: Балинська Марина
Published: December 2024

У статті проаналізовано наукові та теоретичні джерела щодо проблеми тривожності, її ґенези, підліткового віку, особливостей формування тривожності у підлітковому віці, та зокрема у підлітків із тяжкими порушеннями мовлення, а також вплив кризових викликів сучасності на психоемоційний стан та процес спілкування підлітків із тяжкими порушеннями мовлення.
Обґрунтовано важливість дослідження тривожності, як однієї з базових емоційних реакцій, що має значний вплив на формування особистості. Проаналізовано особливості ґенези тривожності. Розглянуто проблему ситуативної та особистісної тривожності. Теоретично досліджено дезорганізуючий характер тривожності, її захисну та мобілізуючу функції. Причини особистісної тривожності розглянуто на психологічному, соціальному та психофізіологічному рівнях. В основі тривожності також зазначено про недостатню сформованість або порушення механізму психологічного самоуправління.
У статті наголошено на важливості соціального характеру ґенези тривожності, зокрема незадоволенні провідних соціогенних потреб, фрустрації соціальних потреб особистості. Тривожність проаналізовано як можливий фактор, що може ускладнювати спілкування підлітків та провокувати виникнення або посилення комунікативних бар’єрів в умовах нормативного розвитку та в умовах мовленнєвого дизонтогенезу. Враховуючи те, що провідною діяльністю підліткового віку є міжособистісне спілкування, тривожність розглянуто саме через призму спілкування та взаємодії підлітків. Окрему увагу в статті приділено ґенезі тривожності підлітків з особливими освітніми потребами, зокрема із тяжкими порушеннями мовлення.
Наголошено на важливості врахування особливостей сучасного суспільства під час дослідження тривожності. А також знайдено місце тривожності у класифікації комунікативних бар’єрів підлітків із тяжкими порушеннями мовлення.
ТЕХНОЛОГІЧНІ АСПЕКТИ КОРЕКЦІЙНО-АБІЛІТАЦІЙНОЇ ВЗАЄМОДІЇ З ДІТЬМИ З ПОРУШЕННЯМИ ПСИХОФІЗИЧНОГО РОЗВИТКУ НЕМОВЛЯЧОГО ТА РАННЬОГО ВІКУ
Authors: Гладченко Ірина
Published: December 2024

З урахуванням важливості якісної дошкільної освіти, що розглядається як інвестиція держави у людський капітал, раннє втручання та психолого-педагогічний супровід дітей з порушеннями психофізичного розвитку постають пріоритетними.
У статті висвітлено питання підвищення ефективності ранньої корекційно-абілітаційної допомоги дітям з порушеннями психофізичного розвитку щодо формування у них соціально-адаптивних навичок взаємодії з соціальним середовищем.
Окреслено потреби дітей у педагогічній підтримці та проаналізовано причини їх виникнення, особливості прояву.
Розглянуто шляхи оптимізації корекційно-абілітаційної взаємодії та методи й прийоми корекційно-абілітаційної взаємодії в діаді «дитина-дорослий», що надає можливість здійснювати підтримку та супровід відповідно до визначених потреб.
КОРЕКЦІЙНО-РОЗВИВАЛЬНИЙ ПРОСТІР МАТЕРИНСЬКОЇ СІМ’Ї: КАТАМНЕСТИЧНИЙ ПІДХІД
Authors: Ханзерук Лілія
Published: December 2024

У статті зроблено спробу дослідити динаміку стану науки та практики виховання дітей з особливими освітніми потребами у материнській сім’ї, яка традиційно в українській ментальності позиціонується як неповна. Дослідження було розпочато в рамках міжнародного наукового проєкту «Human resources in poverty and disability: family perspective» (2013 р.), обговорювалось на VIII Міжнародному конгресі у Лісабоні (2015 р.), а також в окремих публікаціях автора з окресленої теми. Погляд на проблему через призму деятиліття (2014-2024 роки), позначеного руйнівною війною в Україні, видається вкрай актуальним. Адже велика кількість українських родин сьогодні переживають стан, коли відповідальність за виховання дітей покладається цілковито на жінок. У випадках виховання дітей з особливими освітніми потребами ключового значення набуває пошук допомоги дитині як провідний мотив материнської сім'ї. Такий мотив як спонукання до активності, пов’язане з намаганням матері задовольнити особливі освітні потреби дитини, загострює питання виховного ресурсу для створення корекційно-розвивального простору в умовах сім’ї. Позиціонується підхід, відповідно до якого важливості набуває не структура сім’ї, а якість материнства, серед маркерів якого обґрунтовано виділяються такі ключові значення: плекання материнства як частини особистості жінки; адекватність усвідомлення стану дитини і ставлення до її виховання; розуміння перспектив розвитку дитини і можливостей соціальної адаптації; готовність до партнерства у корекційно-реабілітаційній роботі.
FREQUENCY OF UNDIAGNOSED HYPERTENSION IN HEALTHCARE WORKERS OF KHYBER TEACHING HOSPITAL PESHAWAR
Authors: Hussan Jehan , Ahmad Noman , Adnan Fatma , Inayat Rimsha , Kamal Muhammad , Ali Komal
Published: December 2024

Objectives: To measure the frequency and determinents of undiagnosed hypertension in Healthcare Workers of Khyber Teaching Hospital Peshawar and to determine the association of their Hypertension with demographics.Materials and Methods: It was a cross-sectional analytical study done at Khyber Teaching Hospital, Peshawar from January 2023 to May 2023. A sample of 312 healthcare workers was selected by using non-probability convenient sampling technique. A questionnaire having both open-ended & closed-ended questions was used. After acquiring their informed consent, face to face interview along with measuring blood pressure was done. For analysis of the data, statistical package for social sciences (SPSS) version 20 was used. Data was represented using figures and tables. Chi square test was used for analysis.Results: The study included 312 participants with a mean age of 33.8 ± 9.4 years.Out of 312 participants, 62.8% were doctors, 26.9 % were paramedics, and 10.3 % were supporting staff . Among the participants, 40 (12.8%) of the participants were hypertensive, and 272 (87.2%) were non-hypertensive.3.5 % of the participants believed hypertension to be due to stress & anxiety; 3.2 % believed it to be obesity; 2.6 % believed it to be lack of exercise; 1 % believed it to be high salt intake, 0.3 % believed it to be smoking, and 0.3 % believed high cholesterol levels while 89 % believed all of these can be the causes of hypertension. It was found that age, family history of hypertension and Co morbidities were statistically significant, while the other factors turned out to be non significant.Conclusion: A significant number of participants were found hypertensive. Associated factors of hypertension were stress, anxiety, obesity, lack of exercise, high salt intake, smoking, and high cholesterol levels.
Management of Critically Ill Obstetric Patients Admitted in Intensive Care Unit of Enam Medical College Hospital, Savar, Dhaka
Authors: Khanum Easnem , Ara Gulshan , Islam Md Ashraful
Published: December 2024

Background: Pregnancy related complications are more observed in developing countries than developed countries and sometimes need intensive care support to reduce both morbidity and mortality. Any critical condition with acute respiratory failure or hemodynamic insufficiency are the main cause of admission. The management is a great challenge as it is a little bit different from other critically ill patient, should give emphasis on several factors for the fetomaternal wellbeing and needs multidimensional approach. Objectives: The aim of our study was to evaluate the indication of critically ill obstetric patients needed to intensive care support, to assess the fetomaternal outcomes and to observe the applications of different types of interventions needed for the management of these cases. Materials and Methods: A retrospective study was conducted at Enam Medical College Hospital in Bangladesh, with 105 critically ill obstetrics patient admitted in ICU during the period of June 2014 to December 2017. Patients requiring advanced respiratory or ventilator support or needed care of two or more organ system support were fulfilled the criteria for ICU admission. Data were collected from the medical records of Obstetric and Intensive care unit in a preformed sheet, analyzed by SPSS 20.0. ''p'' value of ≤ 0.05 is considered as statistically significant. After admission to the ICU primary resuscitation was done at first then several types of intervention were done immediately as per ICU protocol. Management was done by multidisciplinary approach. Result: Total 105 critically ill obstetric patients were admitted which corresponds 2.66 % of the total ICU admission. Referral cases from outside of the hospital was found 60.95%. Postnatal cases were found 71.42% more than antenatal (28.58%). The most common indication for ICU admission was found as obstetric hemorrhage (50.47%) and hypertensive disorders (32.38%). 49.5% patients needed mechanical ventilation, 57.14% needed ionotropic supports, 85.05% needed transfusions of either blood or blood products, 7.02% needed hemodialysis. Most of the patients (46) were stayed up to 2 days, a few (10) stayed more than 7 days, 26 were stayed 2−3days and 23 were stayed for 3 to 5 days. The maternal death was observed in 25.71% among them most of the cases were due to delayed referral case (77.7%). Conclusion: Obstetric hemorrhage is the most common cause of ICU admission. Early transfer to the ICU may reduce maternal death. Maternal death more found in referral cases. High dependency unit may reduce ICU admission.
J Enam Med Col 2022; 12(1): 9−16
Creutzfeldt-Jakob Disease: A Case Report from a Tertiary Health Care Centre in Bangladesh
Authors: Rahman Nelufa Tahera , Khanum Easnem , Islam Md Ashraful , Begum Nasima , Mondal Kanti , Amin Aiman Mohammed
Published: December 2024

Creutzfeldt-Jakob disease (CJD) is an extremely lethal and rapidly progressive spongiform encephalopathy caused by abnormal form of prion protein. It occurs worldwide with an estimated annual incidence about 1−2 cases per million populations. Several forms of the disease have been described−the most common is the sporadic type. Clinical features include briskly progressive dementia, myoclonus, visual or cerebellar signs, and pyramidal/extra-pyramidal signs. Diagnosis of CJD is usually challenging. Combining clinical features with laboratory parameters, electroencephalogram (EEG), and magnetic resonance imaging (MRI) of the brain expedites the diagnosis. It has no definitive treatment; only symptomatic and supportive managements are provided to the patients. Affected patients generally die within 1 year of the onset of illness. We report a 40-year-old lady who presented with 2 months’ history of rapidly progressive cognitive decline, vertigo and blurring of vision. Her diagnosis was made by classic findings on EEG, MRI of the brain along with clinical features and laboratory parameters. In spite of continuous supportive treatment, she died after 3 months from the onset of her illness. Early diagnosis, extensive research activities regarding prevention and treatment, raising social awareness and educating health care professionals about the disease might improve the current unsatisfying scenario of CJD.
J Enam Med Col 2022; 12(1): 54−58
Study of Serum Calcium and Magnesium Levels in Reproductive Women Using Oral and Injectable Contraceptives
Authors: Rezwana Karim Roshny  , M A Muttalib  , Gazi Sharmin Sultana  , Farzana Akonzee Mishu  , Md Imran Khan Chayon
Published: December 2024

Background: The oral and injectable contraceptives fulfill the human need for birth control with great effectiveness. These can effectively prevent pregnancy and alleviate menstrual disorder when used correctly. Many biochemical profiles of women taking oral and injectable contraceptives are disturbed due to metabolic alterations induced by its hormonal content. Objective: To find out the effects of oral and injectable contraceptives on serum calcium and magnesium levels. Materials and Methods: This cross-sectional comparative study was done in BIRDEM General Hospital, Shaheed Suhrawardy Medical College Hospital and Gandaria Family Planning Clinic of Nagar Shastho Kendro from July 2018 to June 2019. Study parameters serum calcium and magnesium were estimated in each case. One hundred fifty women aged 18 to 45 were included according to the inclusion criteria. They were divided into three groups－50 oral contraceptive users as group I, 50 injectable contraceptive users as group II and 50 normal healthy controls as group III. After taking the informed written consent from the study subjects, a structured questionnaire was filled in for each subject to collect data including personal identification, age, sex, chief complaints, duration of contraceptive use, socioeconomic status, demographic history, family history, genetic history, drug history, menstrual history and history of other systemic diseases. Results: The results of the study showed mean age and SD of the study subjects in Group I, Group II and Group III were 31.08±6.67, 31.60±7.83 and 36.74±6.27 years respectively. Mean (±SD) age was significantly higher in control group (Group III) than Group I and Group II (p <0.001). This study found that mean (±SD) serum calcium of the study subjects in Group I, Group II and Group III were 9.34±0.47, 9.20±0.40 and 9.14±0.49 mg/dL (p <0.05). The mean serum calcium was significantly higher in Group I compared to Group II and III. The mean value of magnesium in Group I, II and III were 0.82±0.09, 0.85±0.11 and 0.80±0.09 mmol/L respectively. There was significant increase in serum magnesium in injectable contraceptive users than oral contraceptive users and control group. Conclusion: This study concluded that oral contraceptives increased the serum calcium and injectable contraceptives increased the serum magnesium levels in comparison with control individuals and these were significant.
J Enam Med Col 2022; 12(2): 95−101
Kesiapan Bahan Ajar Guru dengan Penerapan Kurikulum Merdeka pada Tahun Ajaran 2024-2025 di Sekolah Menengah Atas Islam Terpada Al - Luthfah Cikarang
Authors: Komarudin Abdul Karim , Mayasari Mayasari , Sikki Nurhaeeni
Published: December 2024

The Ministry of Education, Culture, and Research and Technology issued a policy known as the Merdeka Learning curriculum, which aims to optimize the current education program. The commendation of this research is to evaluate the readiness of teachers to implement the Independent Learning Curriculum. This case study involves two teachers and a curriculum waka who implemented this curriculum in high school. Data was collected through interviews, observations, and documentation. Then the data is evaluated through collection, and subtraction, delivery and conclusion. The results of this study show that teachers are quite ready to establish an independent learning curriculum in secondary schools. One of the obstacles for teachers in implementing this curriculum is the lack of understanding between teachers and parents about the independent learning curriculum. In addition, resources and facilities are inadequate.
Reeling: Violence, Exploitation and Artistic Labour in Lola Lafon’s Chavirer (2020)
Authors: Briane Murray Brittany
Published: December 2024

Lola Lafon’s Chavirer (2020) depicts gender-based violence in the arts. This article examines Chavirer’s representation of artistic labor, beginning with a case of abuse and developing a wide-ranging critique of how inequity, exclusion, and exploitation shape artistic labor. The article then discusses how Chavirer adapts aesthetic form to bring artistic labor into the frame of the novel. Finally, the article situates the novel within current debates about artistic autonomy and heteronomy, outlining how the novel intervenes in debates about the specificity of the aesthetic and its response to conditions of artistic labor.
Biologically active additives in gout: opportunities and perspectives
Authors: Shelyabina O. V. , Eliseev M. S.
Published: December 2024

In recent years, there has been a growing interest in the use of biologically active additives (BAA) in the comprehensive management of gout, thereby opening new avenues for both patients and healthcare providers. Gout, as a metabolic disorder, necessitates not only traditional pharmacological interventions but also additional strategies for managing serum uric acid (SUA) levels. BAAs may serve as an important adjunct to existing medical therapies, enabling the reduction of hyperuricemia, the frequency of arthritis flare-ups, and the improvement of patients' quality of life. Research indicates that components of BAAs can modulate inflammatory responses and exhibit diuretic effects, which is particularly relevant for patients with urate nephropathy. However, despite promising results, further clinical trials are required to confirm their safety and efficacy. It is important to note that the integration of BAAs into standard therapy necessitates a careful analysis of interactions with other medications. We are on the brink of a new era in gout treatment, and BAAs may occupy a significant position in this transformation.
Giros Sobre el Eje Longitudinal en la Práctica Motriz. Análisis Bibliométrico
Authors: Rodriguez-Redondo Yeray , León Kiko , Jiménez Rubio Amparo Lucía , Rodal Miguel
Published: December 2024

En el ámbito deportivo, existen numerosas disciplinas que implican rotaciones del eje longitudinal, como la gimnasia, el salto de trampolín, la danza y el patinaje artístico. El objetivo de esta revisión bibliométrica es analizar los deportes y acciones más estudiados que implican este tipo de rotación, así como identificar los autores, revistas y países más prolíficos y destacados, e identificar las palabras clave y artículos más relevantes. Se siguieron las leyes tradicionales de la bibliometría. Los datos se extrajeron de las bases de datos WoS y Scopus. Los resultados mostraron un crecimiento exponencial con un índice de bondad de ajuste del 78.07% entre los 150 documentos analizados. Las 68 revistas se clasificaron en núcleo (4 revistas), zona 1 (16 revistas) y zona 2 (48 revistas). Entre los 298 autores, 24 destacaron como prolíficos y 7 como destacados. EE.UU. fue el país más prolífico y citado. Cabe destacar que los 21 documentos más citados se consideraron relevantes. De las 291 palabras clave, las 17 primeras son relevantes y se distribuyen en tres grupos temáticos. El documento más antiguo, publicado en 1971, está relacionado con el ballet, al igual que el más citado. Los autores más relevantes son M. R. Yeadon y M. J. Hiley, y las revistas principales están relacionadas con la biomecánica.
Estado madurativo en deporte y educación: revisión narrativa
Authors: Ramos Veliz Rafael , Torregrosa Domínguez Adrián , Villalba Arroyo César , Fernández Ozcorta Eduardo J.
Published: December 2024

La maduración biológica genera diferencias significativas entre jóvenes de la misma edad cronológica. Estas disparidades afectan a su rendimiento deportivo, aumentando el riesgo de lesión ante nuevas oportunidades competitivas, siendo un factor crucial en el diseño de programas de entrenamiento y estrategias educativas. Los jóvenes con maduración temprana suelen destacar en capacidades físicas como fuerza y velocidad, lo que les da ventaja en deportes competitivos. Por otro lado, los de maduración tardía enfrentan mayores desafíos para acceder a niveles superiores, a pesar de su potencial a largo plazo. Este sesgo fomenta desigualdades que pueden desmotivar a los deportistas jóvenes. Para abordar estas diferencias, se emplean diferentes métodos para determinar la maduración biológica de los jóvenes, entre los más usados en la actualidad se encuentran los métodos no invasivos a través de diferentes ecuaciones predictivas del pico de velocidad de crecimiento (PHV) o de la estatura adulta esperada (PAH). Estos métodos son usados en estrategias como la Banda Biológica, que agrupa a jóvenes según su maduración y han mostrado eficacia para equilibrar la competencia y mejorar el desarrollo técnico, físico y psicológico. En el ámbito educativo, las investigaciones sobre maduración se han enfocado más en la edad relativa que en la maduración biológica, dejando un vacío sobre su impacto en el rendimiento académico. Incorporar este enfoque podría mejorar el desarrollo integral de los estudiantes. En síntesis, considerar la maduración biológica en entornos deportivos y educativos es esencial para mitigar desigualdades y potenciar el talento individual, aunque aún son necesarios más estudios y herramientas para su aplicación efectiva.