bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro Antineoplastic Activity of Dye Compounds on Human Glioblastoma Cells
Authors: Alexandru Oana , Georgescu Ada Maria , Dragoi Alexandra , Ciurea Marius Eugen , Taisescu Citto Iulian , Tataranu Ligia Gabriela , Brindusa Corina , Boldeanu Mihai Virgil , Purcaru Stefana Oana , Silosi Cristian Adrian , Demetrian Alin , Dricu Anica
Published: January 2020

Dyes are an important class of natural and synthetic compounds, recently studied as potential anticancer drugs. Among various natural dye molecules, Curcumin was extensively studied in treatment of malignant gliomas, a highly incurable disease. Curcumin was reported to induce cell death in malignant gliomas by induction autophagy and apoptosis. We have previously reported that Helianthin, a synthetic dye compound, also induced apoptotic cell death in high grade glioma cells. In this study we evaluated the antiproliferative and the apoptotic effect of Curcumin and Helianthin on a human low passage glioblastoma cell line. We found that both compounds displayed antiproliferative properties on glioblastoma cells, however, at equimolar concentrations, Helianthin induced more cytotoxic effect than Curcumin. IC50 value is considered a good indicator of drug efficacy. We found that Helianthin required a lower concentration to achieve IC50 (16.9.735 �14.8 mM) than Curcumin (68.5 �12.3 mM). We also found that Curcumin and Helianthin treatment induced caspase 3, 8 and 9 activation in glioblastoma cells. This study may lead to a widespread search for dye agents that may represent an untapped source of drugs for cancer treatment.
Time Trends Regarding the Association Between Drug and Tabacco Consumption Among Students from the West Part of Romania. A transversal population study
Authors: Popa Mihaela Diana , Cheveresan Adelina , Dobrescu Amadeus , Bagiu Iulia Cristina , Horhat Delia-Ioana , Susan Razvan , Popescu Simona , Pilut Ciprian , Nitu Razvan , Dahma George , Vlaicu Brigitha , Bagiu Radu Vasile
Published: January 2020

The present research was conducted in order to investigate the tobacco smoker status and intensity in relation to marijuana consumption in students of Timis County, Romania. The representative sample of 2076 students in Timis county, 62.49% girls and 37.51% boys, with the mean age of 21.09 years, was included into a transversal populational study. The sample included 31.1% tobacco smokers and 67.5% nonsmokers. Regarding the tobacco smoking intensity during the previous month, 11.4% smoked between 1-5 cigarettes a day, 8% smoked between 6 and 10 cigarettes a day, 12% smoked more than 10 cigarettes a day, the consumption being significantly higher in boys than in girls. Tobacco smoker students consumed marijuana 8.3 times more frequently than nonsmokers. Heavy smoking students were more frequently marijuana co-users than those smoking tobacco at medium intensity. Tobacco smoker students consumed marijuana 11.44 times more frequently during the prevuious 30 days as compared to nonsmoker students.
The Application of Single Use Bioreactors for the Production of a Carotenoids Mix, Mainly Torularhodin
Authors: Mihalcea Alina , Onu Adrian , Chirvase Ana Aurelia , Ungureanu Camelia
Published: January 2020

The lab scale CellMaker Single Use Bioreactor made by Cellexus and BIOSTAT CultiBagRM Single Use Bioreactor made by Sartorius were tested versus a conventional Bioengineering reactor in order to increase the carotenoidic pigments concentration, mainly torularhodin concentration. For further research with the same yeast it is to consider both: the medium composition with phosphate addition, but also the Single Use Bioreactor Cellexus to get the highest torularhodin concentration in the carotenoids mix.
Retroperitoneal Tumours - Treatment and Prognosis of Tumour Recurrence
Authors: Bratu Ovidiu Gabriel , Cherciu Alexandru Ionut , Bumbu Adrian , Lupu Sorin , Marcu Dragos Radu , Ionita Radu Florentina , Manea Maria , Furau Cristian , Diaconu Camelia Cristina , Mischianu Dan Liviu Dorel
Published: January 2020

Retroperitoneal tumors, once considered uncommon, have been reported in the last years in such numbers that they cannot be considered anymore a rare condition. Tumor recurrence following surgical excision is quite common and a tumor that was considered originally as benign in many cases can recur as a malignant tumor. The purpose of this paper is to underline the difficulties in terms of establishing a correct diagnosis and a proper therapeutic protocol when facing a retroperitoneal mass of unknown origin, as well as to present the available data regarding prognosis, treatment options and tumor recurrence. Retroperitoneal tumors can be classified as benign or malignant; solid, cystic or both; single or multiple, and of varied histological types. A high percentage of patients with retroperitoneal tumors are discovered in advanced stages, usually seeking medical help for symptoms related to nearby organ compression/invasion. This pathology requires a prompt and adequate multidisciplinary management, in order to achieve disease control and to reduce the recurrence rate. Complete surgical resection is the potential curative treatment for retroperitoneal tumors and it is best managed in high-volume centers, by a multidisciplinary team. Complete oncological tumor resection and tumor grade remain the most important predictors for local recurrence and disease-specific survival. Further research is required in order to define the role of radiotherapy, as well as to discover new biological therapies that target various molecular pathways involved in retroperitoneal cancers.
Cardiac Electrical Vulnerability after Acute Myocardial Infarction Associated with Respiratory Infections
Authors: Albulescu Nicolae , Ivan Vlad Sabin , Apostol Adrian , Iovanescu Gheorghe , Ivan Mihaela Viviana , Schiller Adalbert
Published: January 2020

Heart rate variability and the presence of late potentials are independent predictor factors for cardiac death and electrical vulnerability of the ischemic myocardium, especially after myocardial infarction(MI). Respiratory infection are known to be associated with MI both through direct action of the pathogen and by altering the hemodynamic status, through tachycardia and a rise in myocardial oxigen demand. Our paper wants to highlight that respiratory infection during subacute and late recovery phase of myocardial infarction can aggravate the electrical vulnerability of the myocardium and increases the arrhythmic risk. We analysed heart rate variability and the presence of late potentials on signal-averaged ECG in patients who developed acute respiratory infection after MI. All parameters of heart rate variability were signifficantly decreased in our target group. Incidence of late potentials did not differ between the two groups, meaning that the electrophysiological substrate of arrhythmias was not influenced by respiratory infection. Ventricular arrhythmias were more severe and frequent in the infection group. Respiratory infectious disease in early and late recovery phase after acute myocardial infarction, increases the risk of life threatening arrhythmias. It must be emphasized the need to consider prevention and early treatment of respiratory viral or bacterial infections, particularly in patients with cardiac ischemic disease.
Total Mercury in Fish and Benthic Invertebrates Collected from Olt River, Romania
Authors: Vasile Gabriela Geanina , Gheorghe Stefania , Ene Corina , Serban Ecaterina Anca , Stoica Catalina
Published: January 2020

The paper presents an assessment study on the determination of total mercury from biological samples, using Cold-Vapour Atomic Absorption Spectrometry technique which was applied on three certified reference materials: Tuna Fish ERM-CE464, Fly ash BCR-176R and Sandy Soil ERM-CC018. Recovery rates ranged from 100 to 108.8%. The method was applied on contaminated biological real samples, respectively various fish organs (Cyprinus carpio and Carrasius gibelio) as well as two types of bivalves (Dreissena sp. and Anodonta sp.) collected from Olt River after the wastewater discharge of a chemical platform. The preliminary results showed that total Hg content was above the limit allowed by the World Health Organization (0.5 mg/kg) in muscle and spleen samples harvested from carp specimens. In benthic invertebrate specimens, the Hg content ranged from 0.19 to 0.52 mg/kg dry matter in internal organs, while Hg value in shells was below the method quantification limit.
Fluoride Removal from Industrial Effluents by Combining Precipitation and Electrocoagulation Processes
Authors: Ihos Monica , Dragalina Mihaela , Iordache Iuliana , Neidoni Dorian
Published: January 2020

The aim of this study was the removal of fluoride from a fluoride-rich industrial wastewater by combining two processes, precipitation with a magnesium salt and electrocoagulation. The sacrificial anode was made of Al and the applied current densities were of 100, 200 and 300 A/m2, respectively. The experiments were conducted at pH of 5.2, 6.2 and 7.2, respectively, and the electrolysis time was of 15, 30, 45 and 60 min, respectively. 0.01 M NaCl was supporting electrolyte. The best results were obtained at pH of 6.2, 200 A/m2 and 45 minutes of electrolysis when the specific energy consumption was of 5.6 kWh/m3.
Otonomi dan Pembaruan Desa
Authors: Jaweng Robert
Published: January 2020

Dalam tata administrasi publik, kedudukan Desa yang baru berarti mengeluarkan Desa dari subordinasi organisasi negara (sebagai bentuk pemerintahan terendah, wilayah kerja Pemda), kembali menempatkannya sebagai entitas politik otonom dan kesatuan masyarakat hukum yang memiliki regulasi sendiri dalam mengelola kehidupan Desa. Dengan kedudukan demikian, formula hubungan Desa-Pemerintah adalah sebagai mitra setara sehingga urusan dominan Desa lebih bersumber kewenangan orisinal, sementara devolusi/delegasi kerja dalam kerangka desentralisasi dari Negara/Daerah mesti didahului proses “dilebratif” yang hasilnya dituangkan dalam bentuk Perda.
Partisipasi Masyarakat dalam Implementasi Kebijakan Pembangunan di Daerah
Authors: Sutisna Widya
Published: January 2020

Otonomi daerah memungkinkan pemerintah setempat membangun daerahnya sesuai dengan kebutuhan masyarakat. Otonomi daerah memungkinkan masyarakat untuk berpartisipasi dalam proses pembangunan di daerahnya. Partisipasi masyarakat dalam pembangunan diyakini banyak pihak telah menjadi kata kunci dalam pelaksanaan pembangunan di era otonomi daerah sekarang ini. Pembangunan yang tidak melibatkan partisipasi masyarakat ternyata telah gagal menciptakan keadilan dan kesejahteraan masyarakat. Partisipasi merupakan jembatan penghubung antara pemerintah sebagai pemegang kekuasaan, kewenangan, dan kebijakan dengan masyarakat yang memiliki hak sipil, politik dan social ekonomi masyarakat. Sejauh ini, partisipasi masyarakat masih terbatas pada keikutsertaan dalam pelaksanaan program-program atau kegiatan pemerintah, padahal partisipasi masyarakat tidak hanya diperlukan pada saat pelaksanaan tapi juga mulai tahap perencanaan bahkan pengambilan keputusan.
Tratamiento de fisioterapia multimodal basado en un paradigma bioconductual en el abordaje de migraña crónica: Estudio de un caso.
Authors: Suso-Martí Luis , Atger Swann , Cuenca-Martínez Ferran
Published: January 2020

La migraña crónica es una cefalea primaria en la que se producen más de 15 episodios de cefalea al mes. Esta patología es la séptima causa de discapacidad en el mundo, y la literatura científica actual sugiere que un tratamiento multimodal desde un paradigma bioconductual se podría precisar para esta población.Una mujer de 36 años diagnosticada de migraña crónica que presentó cefaleas 30 días al mes y altos niveles de discapacidad. Se evaluaron mediante autoinforme kinesiofobia, pensamientos catastróficos, impacto del dolor de cabeza, discapacidad por migraña y niveles de ansiedad y depresión. Como variables motoras, la resistencia de los flexores profundos y finalmente se registró la frecuencia de dolor.Se tomaron cinco mediciones durante un total de 120 días.Doce sesiones de tratamiento incluyendo terapia manual neuro-ortopédica, ejercicio terapéutico y estrategias bioconductuales, incluyendo educación terapéutica en dolor fueron incluidos.El tratamiento multimodal basado en un paradigma multimodal produjo una reducción sustancial en la frecuencia de las cefaleas, la discapacidad,
Estudio transversal piloto sobre el perfil funcional del paciente en cuidados paliativos. Actividad y desempeño ocupacional
Authors: Carrasco-Tanarro Laura , Carpena-Niño María Gracia , Mendiburu-Aletti Bárbara , Gómez-Martínez Miguel
Published: January 2020

Objetivo: Conocer el nivel de dependencia en actividades de la vida diaria del paciente que recibe cuidados paliativos, estudiando su relación con diferentes variables que pueden afectar en su estado funcional.Diseño: Estudio piloto, observacional, transversal, de prevalencia, cuantitativo, prospectivo y analítico sobre la actividad y el desempeño ocupacional en pacientes de Cuidados Paliativos.Marco: Se realizó en el marco hospitalario del centro de Laguna, Fundación Vianorte-Laguna.Participantes: 34 pacientes cumplían los criterios de selección, pero no todos aceptaron participar. En la muestra se incluyeron 12 pacientes entre 49 y 89 años, diagnosticados de patología oncológica.Intervenciones: Sin intervención.Variables: Se estudiaron las siguientes variables cualitativas: edad, sexo, desempeño y satisfacción y cuantitativas: nivel de dependencia, calidad de vida, dolor, impacto de los problemas de salud y riesgo de deterioro de la integridad cutánea. Análisis estadístico mediante el programa SPSS 20.0.Resultados: Las variables dolor, sueño, estado psicológico, continencia, úlceras por presión, movilidad y energía, se correlacionan de forma estadísticamente significativa (p<0,05) con el nivel de dependencia en las actividades de la vida diaria y su satisfacción.Conclusión: Los pacientes que reciben cuidados paliativos presentan un perfil de dependencia severo en la realización de actividades de la vida diaria. Siendo el dolor, el sueño, el estado psicológico, las úlceras por presión, la movilidad y la energía, factores que limitan su desempeño ocupacional, principalmente en las actividades básicas de la vida diaria.
Implementasi Sistem Pakar Untuk Mendeteksi Gejala Defisiensi Vitamin Pada Tubuh Manusia Pada Puskesmas
Authors: Eka Putri Ranti , Widya Rika
Published: January 2020

Penelitian ini membahas mengenai Sistem Pakar dengan metode Backward Chaining. Rancangan aplikasi dari Sistem Pakar itu sendiri dirancang dengan berbasis web, karena dengan aplikasi berbasis web dapat membantu proses penyebaran informasi dan pengetahuan dengan daerah penyebaran yang lebih luas. Vitamin merupakan nutrien organic yang dibutuhkan dalam jumlah kecil untuk berbagai fungsi biokimiawi dan yang umumnya tidak disintesis oleh tubuh. Vitamin mempunyai berbagai fungsi yang essensial dalam proses metabolisme tubuh yang normal. Kekurangan atau defisiensi terhadap vitamin dapat menjadi masalah bagi kesehatan manusia  sehingga menimbulkan berbagai penyakit pada tubuh.  Untuk membantu orang-orang dalam mengetahui gejala-gejala defisiensi tiap-tiap vitamin pada tubuh yang dapat dilihat dan dirasakannya tanpa harus melakukan konsultasi ke ahli gizi atau dokter, maka perlulah di implementasikan sebuah sistem pakar untuk diagnosa defisiensi vitamin.
Implementation Of Data Mining For Determining Majors Using K-Means Algorithm In Students Of SMA Negeri 1 Pangkalan Kerinci
Authors: Yuda Irawan
Published: January 2020

SMA Negeri 1 Pangkalan kerinci is one of the middle schools located at Jalan Lintas Timur Kerinci Pelalawan Indonesia which currently has 2 majors namely Science and IPS. This student majors can lead learners to focus more on developing their own abilities and interests. Selection of inappropriate majors can be very detrimental to students of their interests and careers in the future. With the majors are expected to maximize the potential, talent or individual talents, so as to maximize academic value. Based on the background, then by applying data mining techniques are expected to help students to determine the correct majors in accordance with the criteria set. Data mining techniques used in the determination of this department using K-Means Algorithm.
Persepsi Konsumen Terhadap Produk Private Label Perusahaan Ritel
Authors: Susianti Susianti , Amandin
Published: January 2020

The purpose of the research to determine consumer perceptions of private label products Indomaret compared with similar products from national brands in Indomaret Prabumulih. This study examined three independent variables, namely the element of private label brand awareness (X1), the perception of the quality of the product (X2), the perception of value (X3) which may affect the dependent variable. The method used in the sampling in this study is the sampling method accidental (accidental sampling. Determination of the area of ​​research done intentionally (purposive) in Indomaret Prabumulih South Sumatra. The results of test f show obtained probability (Sig) is 0,000. Because the value Sig <0.05 (0.000 <0.05), then the decision is H0 rejected and Ha accepted. her significant conclusion means that, brand awareness, perceived quality and perceived value products together or simultaneously to significantly influence consumer perceptions of products private label on Indomaret Prabumulih. Then compare the value of F with Ftabel from the above table it is known that the value Fhitung 68.535. Therefore we can conclude that F count> F table (68.535> 2.70), meaning that brand awareness, perceived quality and perceived value products together or simultaneously significant effect on consumer perception on the I ndomaret Prabumulih. The hypothesis is accepted. 

Keywords: Brand Awareness, Perceptions of Product Quality, Perceived Value and Consumer perception, Private Label.
Pengaruh Bauran Pemasaran (7p) terhadap Keputusan Pembelian Motor Yamaha Tipe Nmax
Authors: Akhiri Samron
Published: January 2020

The purpose of the research to determine the effect of marketing mix (7p) Buying Decision Against Type Nmax At Yamaha Motor PD. Panca Motor Prabumulih This type of research is the method used in this research is survey method. Data collected consist of primary data and secondary data. The primary data obtained through interviews method which is equipped with a questionnaire has been prepared. In this study the number of population is not known, therefore, that according to Widiyanto in Vina Agustina (2012: 56) to determine the sample size of the population can use the formula. So a sample to be used is a total of 96 customers in PD. Panca Motor Prabumulih. Respondent data collected by collecting primary data, which collects data by distributing questionnaires were collected by questionnaire purchasing decisions. Data was analyzed using correlation and regression analysis. The results showed that, of the model output obtained summary table of test results gives the coefficient of determination R Square of 0.744. This shows that the variable marketing mix (product, price, distribution, promotion, people, process and physical environment) simultaneously percentage contribution of the influence of independent variables have an influence on the dependent variable (Decision consumers to shop), amounting to 74.4%. Or the independent variable (product, price, distribution, promotion of people, processes and physical environment) amounted to 74.4% were able to explain the dependent variable (Decision consumers to shop), while the remaining 25.6% influenced or explained by other variables not examined in this research. 

Keywords: Marketing Mix (7P), Purchase Decision
ANALISIS RASIO KEUANGAN UNTUK MEMPREDIKSI KONDISI FINANCIAL DISTRESS PERUSAHAAN PULP DAN KERTAS YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2012-2017 DENGAN MODEL ALTMAN Z-SCORE
Authors: Sari Maya , Diana Haugesti
Published: January 2020

Identification conditions of financial difficulties is more important than bankruptcy, because companies will surely experience financial distress conditions first and then go bankrupt. This studi aims to examine the effect of the Current Ratio (QR), Quick Ratio (QR), Debt to Equity Ratio (DER), Return On Assets (ROA), and sales growth on the financial distress conditions of the pulp and paper subsector companies listed on the indonesi stock exchange from 2012 to 2017. This study use a quantitative approach. The study population included all pulp and paper subsector companies listed on the Indonesia stock exchange from 2012 to 2017, namely 8 companies. The sample was determined by purpose sampling technique. Data analysis method used is logistic regression analysis. The results of thr study showed that the best performance of the company with the lowest level of bankruptcy was PT. Kedawung Setia Industrial Tbk. From the results of testing multiple linear regression obtained Roa has a significant effect on the condition of financial distress. Whereas CR, QR, DER and Sales Growth do not effect the financial condition of the distress.
PENGARUH COMPETITOR ACCOUNTING TERHADAP KEUNGGULAN BERSAING DAN KINERJA ORGANISASI
Authors: Astuti Mona , Azmi Zul , Darwin Ranti
Published: January 2020

The purpose of this study was to know the affect of Competitor Accounting as a Strategic Management Accounting Techniques towards Competitive Adventage and Organization Performance. On business culinary in Pekanbaru. This study used a questionnaire to obtain primary data with a sample size of 38 respondents and was tested using path modeling analysis techniques. From the examination showed that there were positive affect of Competitor Accounting as a Strategic Managemengt Acounting Techniques towards Competitive Adventage, negative affect of Competitor Accounting as a Strategic Managemengt Acounting Techniques towards Organization Performance, positive affect of Competitive Adventage towards Organization Performance, and positive indirectly affect of Competitor Accounting as a Strategic Managemengt Acounting Techniques towards Organization Performance with Competitive Adventage mediation.
Two-zone Spatially Dependent Model of the Nonthermal Emission from Plerionic Supernova Remnant G21.5-0.9
Authors: Lu Fang-Wu , Gao Quan-Gui , Zhang Li
Published: January 2020

Observations of plerionic supernova remnant (SNR) G21.5-0.9 indicate an extended X-ray halo surrounding the bright central pulsar wind nebula (PWN), and that the photon index and the surface brightness of the SNR have been discovered to change with the increase of radial distance in the X-ray band. To explain the observational features of this source, a two-zone spatially dependent model with a slow diffusion in the PWN and a fast diffusion in the extended region is proposed in this paper. In the model, the evolution of electron inside the entire remnant is described with a particle transport equation under the assumption of a spherically symmetric system with dynamical evolution. The observed photon spectral energy distribution of the central PWN, as well as the radial profiles of the photon index and surface brightness observed in the X-ray band of the entire remnant, can be well reproduced in the framework of the model. The modeling results reveal that the X-ray halo of SNR G21.5-0.9 is mainly due to the synchrotron radiation of the accelerated electrons derived from the PWN shock, and the current diffusion coefficient in the extended region has a value of 1.7 × 1028 cm2 s−1 at an electron energy of 1 TeV, which is much larger than the obtained spatial averaged diffusion coefficient of 2.5 × 1025 cm2 s−1 in the central nebula.
Three-dimensional Dissipative Pulsar Magnetospheres with Aristotelian Electrodynamics
Authors: Cao Gang , Yang Xiongbang
Published: January 2020

A good compromise between the resistive model and the particle-in-cell model is Aristotelian electrodynamics, which can include the back-reaction of the radiative photons onto particle motion and allow for a local dissipation where the force-free condition is violated. We study the dissipative pulsar magnetosphere with Aristotelian electrodynamics where particle acceleration is fully balanced by radiation. The expression for the current density is defined by introducing a pair multiplicity. The 3D structure of the pulsar magnetosphere is then presented by solving the time-dependent Maxwell equations using a pseudo-spectral algorithm. It is found that the dissipative magnetosphere approaches the force-free solution and the dissipative region is more restricted to the current sheet outside the light cylinder (LC) as the pair multiplicity increases. The spatial extension of the dissipative region is self-consistently controlled by the pair multiplicity. Our simulations show the high magnetospheric dissipation outside the LC for the low pair multiplicity.
Comparison of Kinematics of Solar Eruptive Prominences and Spatial Distribution of the Magnetic Decay Index
Authors: Myshyakov Ivan , Tsvetkov Tsvetan
Published: January 2020

Theoretical studies of electric current instability explaining solar prominence eruptions show that the loss of equilibrium may develop in a case when the surrounding magnetic field decreases sufficiently rapidly with height. The magnetic decay index, a parameter indicating whether the external magnetic field has a configuration that may lead to a certain type of electric current instability, is a useful instrument for predicting the behavior of prominences. In our study, we consider three eruptive prominences. We perform potential-field extrapolation to obtain the spatial distribution of the magnetic decay index in the coronal space identified with the prominences. Analysis of time-dependent height profiles of the prominences revealed that eruptions started at heights close to those, where the computed magnetic decay index exceeded a value equal to 1.5. This indicates that the torus instability is a possible mechanism of the considered eruptive events.
Magnetic Field Dependence of Bipolar Magnetic Region Tilts on the Sun: Indication of Tilt Quenching
Authors: Jha Bibhuti Kumar , Karak Bidya Binay , Mandal Sudip , Banerjee Dipankar
Published: January 2020

The tilt of the bipolar magnetic region (BMR) is crucial in the Babcock–Leighton process for the generation of the poloidal magnetic field in the Sun. Based on the thin flux-tube model of the BMR formation, the tilt is believed to be caused by the Coriolis force acting on the rising flux tube of the strong toroidal magnetic field from the base of the convection zone. We analyze the magnetic field dependence of BMR tilts using the magnetograms of the Michelson Doppler Imager (1996–2011) and Helioseismic and Magnetic Imager (2010–2018). We observe that the distribution of the maximum magnetic field (B
max) of BMRs is bimodal. Its first peak at the low field corresponds to BMRs that do not have sunspots as counterparts in the white-light images, whereas the second peak corresponds to sunspots as recorded in both type of images. We find that the slope of Joy’s law (γ
0) initially increases slowly with the increase of B
max. However, when B
max ≳ 2 kG, γ
0 decreases. Scatter of the BMR tilt around Joy’s law systematically decreases with the increase of B
max. The decrease of observed γ
0 with B
max provides a hint to a nonlinear tilt quenching in the Babcock–Leighton process. We finally discuss how our results may be used to make a connection with the thin flux-tube model.
Coronal Properties of Black Hole X-Ray Binaries in the Hard State as Seen by NuSTAR and Swift
Authors: Yan Zhen , Xie Fu-Guo , Zhang Wenda
Published: January 2020

In this work we measure two important phenomenological parameters of corona (and hot accretion flow) in black hole X-ray binaries: the photon index Γ and the electron temperature

. Thanks to the capability of the Nuclear Spectroscopic Telescope Array in hard X-rays, we measure these two parameters over six orders of magnitude in the 0.1–100 keV X-ray luminosity

, from ∼5 × 1038

down to as low as ∼5 × 1032

. We confirm the existence of a “V”-shaped correlation between Γ and

. Surprisingly, we observe a “Λ”-shaped correlation between

and

. The “cooler when brighter” branch in the high-luminosity regime (

≳ 3 × 1036

) agrees with previous results and can be understood under the existing model of Compton scattering in the corona. On the other hand, the apparent “cooler when fainter” (positive

–

correlation) branch in the low-luminosity regime (

≲ 3 × 1036

) is unexpected, thus it puts a new challenge to existing models of hot accretion flow/corona.
On Araniella and Neoscona (Araneae, Araneidae) of the Caucasus, Middle East and Central Asia
Authors: Zamani Alireza , Marusik Yuri M. , Šestáková Anna
Published: January 2020

New taxonomic data for species belonging to Araniella Chamberlin & Ivie, 1942 and Neoscona Simon, 1864 occurring in the Caucasus, Middle East and Central Asia are provided. Three species are described as new to science: A. mithrasp. nov. (♂♀, northwestern, central and southwestern Iran), A. villaniisp. nov. (♂♀, southwestern Iran, eastern Kazakhstan and northern India) and N. isatissp. nov. (♂♀, central Iran). Neoscona spasskyi (Brignoli, 1983) comb. nov., stat. res. is removed from the synonymy of N. tedgenica (Bakhvalov, 1978), redescribed and recorded from Iran and Turkmenistan for the first time. New combinations are established for this species, as well as for Araniella nigromaculata (Schenkel, 1963) comb. nov. (♀, north-central China) (both ex. Araneus). Two new synonymies are proposed: Araniella tbilisiensis Mcheidze, 1997 syn. nov. is synonymized with A. opisthographa (Kulczyński, 1905), and Neoscona sodom Levy, 1998 syn. nov. is synonymized with N. theisi (Walckenaer, 1841); the latter is recorded from Iran, Georgia, and Russia (Northern Caucasus) for the first time.
Reflexive and unmarked anticausatives in French and Spanish: Frequency of transitive use and undergoer overlap
Authors: Heidinger Steffen
Published: January 2020

En français comme en espagnol, les verbes anticausatifs apparaissent sous deux formes distinctes : avec ou sans le clitique se . Nous prenons comme point de départ l’hypothèse suivante : se est un opérateur de valence qui réduit la valence verbale par l’élimination de l’argument actor d’une entrée lexicale à deux arguments. Nous évaluons deux prédictions qui découlent de cette hypothèse : (i) les verbes qui forment l’anticausatif avec se s’emploient plus fréquemment comme transitifs-causatifs que les verbes qui le forment sans se  ; (ii) l’argument undergoer dans l’anticausatif avec se correspond plus souvent à l’argument undergoer rencontré dans le transitif-causatif que l’argument undergoer dans l’anticausatif sans se . À l’aide de données de corpus, nous montrons que les deux prédictions se confirment. Ainsi, les données corroborent l’hypothèse que seul l’anticausatif avec se se forme par l’élimination de l’argument actor .
Le médiopassif à la lumière des verbes anticausatifs et du passif : propriétés argumentales et aspectuelles
Authors: Knittel Marie-Laurence
Published: January 2020

Nous examinons les propriétés argumentales et aspectuelles du médiopassif. Par la comparaison de cette voix, d’une part, avec les verbes anticausatifs réfléchis qui sont formellement identiques et, d’autre part, avec le passif, dont il partage certains emplois, nous mettons en évidence quelques facteurs qui conditionnent son apparition. Nous montrons notamment que le verbe doit être événementiel et sélectionner un sujet conscient à la forme transitive. Nous avançons également que, même lorsqu’il est employé dans une forme verbale composée, il refuse la valeur résultative.
Le conflit et les origines de la métaphore
Authors: Trim Richard
Published: January 2020

Cette étude examinera la notion de conflit conceptuel , définie par Prandi (2017), dans le cadre de l’étude des origines de la métaphore. Cette approche sera comparée à la Théorie de la Métaphore Conceptuelle, définie par Lakoff & Johnson (1980), qui propose des schémas fondamentalement physiologiques pour la créativité métaphorique. Cette dernière approche concerne, selon les propos de Prandi, des modèles conventionnels qui impliquent plutôt le langage du quotidien. Par conséquent, la gamme créative des « métaphores vives », définies par Ricoeur (1985), est exclue. En outre, les métaphores vives provoquent un conflit conceptuel qui est absent des modèles conventionnels. L’étude suivante analysera la différence entre ces deux approches par rapport au discours littéraire. Les résultats confirment que le conflit conceptuel joue effectivement un rôle important dans les processus créatifs.
Les mangas : faire entrer les lectures privées à l’école et les constituer en objets littéraires
Authors: Suvilay Bounthavy , Taddei Édith
Published: January 2020

La présence de mangas dans les référentiels de lecture des Programmes officiels de 2016 atteste leur intégration progressive à l’école et constitue ainsi un des marqueurs externes de littérarité de ces fictions appartenant au genre de l’iconotexte. La question du choix de l’ouvrage serait alors résolue, tandis que resterait en suspens celle des compétences de l’enseignant à identifier les marqueurs internes de la littérarité du manga, et à constituer celui-ci en objet d’apprentissage d’ordre littéraire. L’hypothèse est qu’il est possible et pertinent de s’appuyer sur les lectures personnelles des élèves pour proposer en cycle 3 une analyse selon trois perspectives : le manga comme récit de littérature jeunesse, comme œuvre traduite et comme fiction transmédiatique. Celles-ci visent à démontrer la valeur littéraire d’une œuvre plébiscitée et conjointement à sortir le manga de son rôle de support pédagogique dans lequel il est le plus souvent cantonné. L’étude prend exemple sur l’un des titres qui emporte l’adhésion des jeunes lecteurs  Naruto : récit d’apprentissage emblématique d’un jeune héros éponyme s’inscrivant dans une tradition narrative et légendaire.
Excimer Laser Phototherapeutic Keratectomy for Recurrent Erosions: A Clinical Study
Authors: Lohmann Chris P , Sachs Helmut , Marshall John , Gabel Veit-Peter
Published: January 2020

* BACKGROUND AND OBJECTIVE: Recurrent corneal erosion is a common corneal disease. It may be difficult to treat, with a number of patients suffering persistent symptoms despite having had conventional therapy. The aim of this study was to evaluate the usefulness of the excimer laser for the treatment of recurrent corneal erosions.

* PATIENTS AND METHODS: The authors studied 31 eyes of 24 patients who underwent excimer laser phototherapeutic keratectomy (PTK) for recurrent corneal erosion. Three eyes were treated during an acute episode of recurrent erosion. The remaining eyes were treated during a symptom-free interval. The affected area of epithelium was removed and a 25 pulse ablation was performed to Bowman's membrane.

* RESULTS: In 30 eyes there was a marked improvement in symptoms postoperatively, with no recurrences. However, 1 eye had one recurrent episode 2 weeks after PTK. Postoperatively, refraction and corneal topography were unaltered in all cases.

* CONCLUSIONS: Excimer laser PTK appears to be a safe and promising procedure for cases of recurrent corneal erosion refractory to medical treatment.

[Ophthalmic Surg Lasers 1996;27:768-772.]
Finite time blow-up for a wave equation with dynamic boundary condition at critical and high energy levels in control systems
Authors: Dai Xiaoqiang , Yang Chao , Huang Shaobin , Yu Tao , Zhu Yuanran
Published: January 2020

We study the initial boundary value problem of linear homogeneous wave equation with dynamic boundary condition. We aim to prove the finite time blow-up of the solution at critical energy level or high energy level with the nonlinear damping term on boundary in control systems.
Managing the Utilization of Technologies in Adult Education, Training, and Administration
Authors: Durnali Mehmet
Published: January 2020

This study aimed to investigate and discuss the technologies in Turkey's adult education system in a holistic, systematic way and within a framework with a theoretical basis for the use of the computer, the internet, and web-based technologies in adult education, training, and administration. The web-based applications such as EBA and A-Okul can be very useful for enabling adult learners to acquire a diploma or some certificate. Being able to use technological applications considering all functions and subdivisions can mean learning many tasks, activities, processes, and requirements in adult education. Therefore, it is important to acquire the skills necessary to use these technologies since the algorithms contained in these technological applications are a reflection of the steps of necessary and inclusive tasks, activities, processes in the administration of adult education. The development of the technological capacity of the organization may mean increasing the productivity of the organization.
Administering Education and Training Through a Web-Based System
Authors: Susam Tuncer , Durnali Mehmet , Orakci Şenol
Published: January 2020

The chapter aims to describe e-Curriculum System of the Turkish Ministry of National Education (MoNE) in the context of administering education and training. The system, as a web-based educational administration tool, its benefits to administering, and importance of it were introduced at first. A brief organizational and technological structure of MoNE and reason to implement the system were given. The system's curriculum module (acquisition management system), book review module, annual plan module, question bank module were explained in detail. As a result of the implementation of such an e-curriculum and its components, it is clear that a strong and vivid curriculum administering structure has been forming in MoNE. This system is beneficial for the highly centralized organization of MoNE by helping to coordinate all stakeholders. The MoNE will conduct education administration more professionally, and teachers in Turkey will teach in an educational environment where their problems are solved easily and quickly.
Information and Communication Technologies Literacy
Authors: Çoban Ömür
Published: January 2020

FATIH Project on behalf of the integration of technology in education is one of the most important projects carried out in Turkey. No doubt, teachers will be able to effectively use such an important project in education. Therefore, the capacities of technology should be increased with changes to be made in the pre-service and in-service training of teachers such as educational content and educational environments. The aim of this study is to evaluate the teacher trainings given within the scope of the FATIH Project. The research focuses on training planners, trainers, and training areas to evaluate the training of the project. It is thought that this aspect of the research will give an idea to the top managers at the Ministry of National Education (MoNE). Therefore, this study examines the training given to teachers in the use of educational technology in classrooms in Turkey and whether teachers reveal their role in order to create added value for the country as a result of the training.
Digital Terrorism Attack
Authors: Parkavi R.  , Nithya R.  , Priyadharshini G.
Published: January 2020

In this rapidly growing era of technology, terrorist organizations do not ultimately depend on weapons, army, bombs, and lethal weapons to inflict terror. As the entire earth is developing at a rapid pace, so do the terrorists. The strategies adopted by them have become cannier and more sinister. In addition to that, they no longer involve in training, making tedious plans, undergoing physical training, and subjecting their allies to physical attacks. Rather, they impose serious threats by attacking their victims by vandalizing the online infrastructure. This can be done conveniently from any part of the globe, thus enabling them to use the dark side of the internet. This chapter focuses on digital terrorism attacks, its impact, and it furnishes certain methods for prevention.
Development and Various Critical Testing Operational Frameworks in Data Acquisition for Cyber Forensics
Authors: Anand Abhineet , Arvindhan M.
Published: January 2020

Digital forensics is the science of preserving and analyzing digital data; this data can then be used in court cases as well as for crime detection and prevention. Digital forensics began in the 1970s and was initially used as a tool for fighting financial crime. Today, with computers and digital devices being an integral part of our professional and private lives, digital forensics are used/needed in a wide variety of disputes. Data Acquisitions is described and discuss different techniques or methodology obtain the data, facts, and figures from different resource and at a different level of the system.
Digital Crime Evidence
Authors: Parkavi R.  , Divya K.  , Ruth V. Sherry
Published: January 2020

With the advent of computers, there came computer-related crimes; hence, there comes the need for cybercrime judicial proceedings. And for any trial, evidence plays an instrumental role in bringing the victim to justice. So, there is a need for digital evidence. Digital crime evidence forms a core for the field of computer forensics. Breaking down the term digital crime evidence to be understood in simple words, it is the collection of data and information that plays a crucial role in digital crime investigation and that is usually stored and transmitted in electronic formats. Digital evidence is defined as any data stored or transmitted using a computer that supports or refute a theory of how an offense occurred or that address critical elements of the offense such as intent or alibi. This data is commonly a combination of text, audio, images, and videos. This evidence is generally invisible, fragile, time-sensitive, and integrity will be lost if they are mishandled.
Digital Forensics and Data Mining
Authors: Suaib Mohammad , Akbar Mohd. , Husain Mohd. Shahid
Published: January 2020

Digital forensic experts need to identify and collect the data stored in electronic devices. Further, this acquired data has to be analyzed to produce digital evidence. Data mining techniques have been successfully implemented in various applications across the domains. Data mining techniques help us to gain insight from a large volume of data. It helps us to predict the pattern, classify the data, and other various aspects of the data based on the users' perspective. Digital forensics is a sophisticated area of research. As the information age is revolutionizing at an inconceivable speed and the information stored in digital form is growing at a rapid rate, law enforcement agencies have a heavy reliance on digital forensic techniques that can provide timely acquisition of data, zero fault data processing, and accurate interpretation of data. This chapter gives an overview of the tasks involved in cyber forensics. It also discusses the traditional approach for digital forensics and how the integration of data mining techniques can enhance the efficiency and reliability of the existing systems used for cyber forensics.
Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4
Authors: Juul-Madsen Kristian , Qvist Per , Bendtsen Kirstine L. , Langkilde Annette E. , Vestergaard Bente , Howard Kenneth A. , Dehesa-Etxebeste Martxel , Paludan Søren R. , Andersen Gregers Rom , Jensen Poul Henning , Otzen Daniel E. , Romero-Ramos Marina , Vorup-Jensen Thomas
Published: January 2020

Aggregation of α-synuclein (αSN) is an important histological feature of Parkinson disease. Recent studies showed that the release of misfolded αSN from human and rodent neurons is relevant to the progression and spread of αSN pathology. Little is known, however, about the mechanisms responsible for clearance of extracellular αSN. This study found that human complement receptor (CR) 4 selectively bound fibrillar αSN, but not monomeric species. αSN is an abundant protein in the CNS, which potentially could overwhelm clearance of cytotoxic αSN species. The selectivity of CR4 toward binding fibrillar αSN consequently adds an important αSN receptor function for maintenance of brain homeostasis. Based on the recently solved structures of αSN fibrils and the known ligand preference of CR4, we hypothesize that the parallel monomer stacking in fibrillar αSN creates a known danger-associated molecular pattern of stretches of anionic side chains strongly bound by CR4. Conformational change in the receptor regulated tightly clearance of fibrillar αSN by human monocytes. The induced change coupled concomitantly with phagolysosome formation. Data mining of the brain transcriptome in Parkinson disease patients supported CR4 as an active αSN clearance mechanism in this disease. Our results associate an important part of the innate immune system, namely complement receptors, with the central molecular mechanisms of CNS protein aggregation in neurodegenerative disorders.
Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases
Authors: Chen Heng-Yi , Wu Yen-Fei , Chou Feng-Cheng , Wu Yu-Hsuan , Yeh Li-Tzu , Lin Kuo-I , Liu Fu-Tong , Sytwu Huey-Kang
Published: January 2020

Galectin-9 is a risk gene in inflammatory bowel disease. By transcriptomic analyses of ileal biopsies and PBMCs from inflammatory bowel disease patients, we identified a positive correlation between galectin-9 expression and colitis severity. We observed that galectin-9–deficient T cells were less able to induce T cell–mediated colitis. However, several mouse-based studies reported that galectin-9 treatment induces T cell apoptosis and ameliorates autoimmune diseases in an exogenously modulated manner, indicating a complicated regulation of galectin-9 in T cells. We found that galectin-9 is expressed mainly inside T cells, and its secreted form is barely detected under physiological conditions. Endogenous galectin-9 was recruited to immune synapses upon T cell activation. Moreover, proximal TCR signaling was impaired in galectin-9–deficient T cells, and proliferation of these cells was decreased through an intracellularly modulated manner. Th17 cell differentiation was downregulated in galectin-9–deficient T cells, and this impairment can be rescued by strong TCR signaling. Taken together, these findings suggest that intracellular galectin-9 is a positive regulator of T cell activation and modulates the pathogenesis of autoimmune diseases.