bluuebunny/crossref_metadata_2025 huggingface dataset:
Peirce on facts, propositions, and the index
Authors: Atkins Richard Kenneth
Published: March 2019

Peirce holds that our logic should be the basis for our metaphysics. He also thinks that facts and propositions are structurally isomorphic. However, unlike many theorists who take propositions such as snow is white and grass is green as their paradigmatic examples, Peirce takes it rains (Latin: pleurit) and similar propositions as his paradigmatic examples. I explore how his analysis of such propositions and the way in which they convey meaning becomes more complex from 1895 to 1909, how this impacts his metaphysics, and how he can claim that something like the common environment of two interlocutors can itself be an index.
High-pressure synthesis and crystal structure of the mixed-cation borate Ga4In4B15O33(OH)3
Authors: Vitzthum Daniela , Huppertz Hubert
Published: March 2019

The mixed cation triel borate Ga4In4B15O33(OH)3 was synthesized in a Walker-type multianvil apparatus at high-pressure/high-temperature conditions of 12.5 GPa and 1300°C. Although the product could not be reproduced in further experiments, its crystal structure could be reliably determined via single-crystal X-ray diffraction data. Ga4In4B15O33(OH)3 crystallizes in the tetragonal space group I41/a (origin choice 2) with the lattice parameters a = 11.382(2), c = 15.244(2) Å, and V = 1974.9(4) Å3. The structure of the quaternary triel borate consists of a complex network of BO4 tetrahedra, edge-sharing InO6 octahedra in dinuclear units, and very dense edge-sharing GaO6 octahedra in tetranuclear units.
Analysis of Selected Lymphocyte (CD45+) Subset Distribution in Capillary Blood of Young Soccer Players
Authors: Nowak Robert , Kostrzewa-Nowak Dorota , Buryta Rafał
Published: March 2019

Nowak, R, Kostrzerwa-Nowak, D, and Buryta, R. Analysis of selected lymphocyte (CD45+) subset distribution in capillary blood of young soccer players. J Strength Cond Res 35(8): 2279–2286, 2021—Mechanisms responsible for increasing athletes' physical capacity and induction of exercise-induced immunosuppression processes are not fully understood. The aim of the study was to monitor changes in percentages of lymphocyte subsets: T, Th, Tc, B, and NK cells in capillary blood of junior soccer players. Ten subjects median aged 18 years (range 17–19 years) were recruited form young soccer players. Capillary blood was collected 24 hours after each soccer match during the 8 weeks of the final phase of Central Junior League competition, and white blood cell (WBC) phenotyping was performed to determine the percentages of B lymphocytes, NK cells, and T-lymphocyte subsets. Cumulative match-time (a sum of time spend playing the game by each athlete during the observation period) was also calculated. Significant changes in the percentage of total lymphocytes (p = 0.00005) and T cells (p = 0.00006) were observed. The slight increases in lymphocytes' and Th cells' median percentages correlated with increasing cumulative match-time of studied subjects, although the correlation was not strong (R = 0.24; p = 0.0205 and R = 0.30; p = 0.0035, for lymphocytes and Th cells, respectively). It seems that the exercise bouts are among considerable factors influencing the changes in WBC subsets, especially in CD3+ cells, among young soccer players. Regarding the number of games played and training loads, they are more susceptible to immunosuppression and subsequent infections and thus should be monitored regarding WBC phenotype assessment.
Using an Inertial Device (WIMU PRO) to Quantify Neuromuscular Load in Running: Reliability, Convergent Validity, and Influence of Type of Surface and Device Location
Authors: Gómez-Carmona Carlos D. , Bastida-Castillo Alejandro , González-Custodio Adrián , Olcina Guillermo , Pino-Ortega José
Published: March 2019

Gómez-Carmona, CD, Bastida-Castillo, A, González-Custodio, A, Olcina, G, and Pino-Ortega, J. Using an inertial device (WIMU PRO) to quantify neuromuscular load in running: reliability, convergent validity, and influence of type of surface and device location. J Strength Cond Res 34(2): 365–373, 2020—Currently, the use of accelerometers in sport is increasing, and thus, the devices are required to be valid and reliable. This study tested (a) the reliability and validity of WIMU PRO accelerometers to measure PlayerLoad (PL) and (b) the influence of speed, inertial device location, and type of surface where the incremental test is performed. Twenty resistance-trained men (age: 27.32 ± 6.65 years; height: 1.74 ± 0.03 m; body mass: 68.96 ± 4.37 kg; and body mass index: 22.76 ± 1.11 kg·m−2) volunteered to participate in the study that lasted 5 weeks. Four progressive incremental tests were performed in treadmill and athletic track conditions. External load variable (PL) and physiological variables (heart rate [HR] and SmO2) were recorded by 4 WIMU PRO inertial devices (scapulae, center of mass, knee, and ankle), a GARMIN HR band, and a MOXY near-infrared spectroscopy device, respectively. High reliability was found on both types of surface, showing the best values at the ankle (treadmill: intraclass correlation coefficient [ICC] = 0.99, coefficient of variation [CV] = 4.65%; track: ICC = 0.96, CV = 6.54%). A nearly perfect convergent validity was shown with HRAVG (r = 0.99) and a moderate one with SmO2 (r = −0.69). Significant differences in the PL variable between surfaces were reported in all locations except the scapulae (p = 0.173), and the higher values were found on the track. In the analysis per location, the ankle location reported the highest values at all speeds and on the 2 surfaces analyzed. Assessment needs to be individualized, due to the great variability of gait biomechanics among subjects. The accelerometer location should be chosen according to the purpose of the measurement, with the ankle location being recommended for neuromuscular load analysis in running.
Short-Term Delayed Effects of Kinesio Taping on Sprint Cycling Performance
Authors: Trecroci Athos , Formenti Damiano , Rossi Alessio , Esposito Fabio , Alberti Giampietro
Published: March 2019

Trecroci, A, Formenti, D, Rossi, A, Esposito, F, and Alberti, G. Short-term delayed effects of Kinesio taping on sprint cycling performance. J Strength Cond Res 33(5): 1232–1236, 2019—The aim of this study was to assess short-term delayed effects of Kinesio taping (KT) on maximal cycling performance. A design with repeated measures was used. Fifteen healthy trained subjects underwent 3 conditions: no KT (without tape), KT (Kinesio tape applied longitudinally on the thighs), and sham taping (Kinesio tape applied horizontally on the thighs). Each subject performed 2 sets of 3 × 6-second sprints (separated by 3 minutes) interspersed by 30 minutes of rest on a cycle ergometer. Allometric scaling of peak power (PP) and average power (AP) values were computed and analyzed for each sprint performance. Both PP and AP decreased significantly after 30 minutes (between set 1 and set 2) in all conditions, with a greater decrease in no KT condition compared with KT and sham (p < 0.01). No significant differences were observed between KT and sham conditions. The application of KT on thigh muscles attenuated the performance decrease that occurred after 30 minutes of rest between the 2 sets compared with the no KT condition. This finding suggests athletes may use KT to better manage their performance during delays in competition events.
HNCcorr: A Novel Combinatorial Approach for Cell Identification in Calcium-Imaging Movies
Authors: Spaen Quico , Asín-Achá Roberto , Chettih Selmaan N. , Minderer Matthias , Harvey Christopher , Hochbaum Dorit S.
Published: March 2019

Calcium imaging is a key method in neuroscience for investigating patterns of neuronal activityin vivo. Still, existing algorithms to detect and extract activity signals from calcium-imaging movies have major shortcomings. We introduce the HNCcorr algorithm for cell identification in calcium-imaging datasets that addresses these shortcomings. HNCcorr relies on the combinatorial clustering problem HNC (Hochbaum’s Normalized Cut), which is similar to the Normalized Cut problem of Shi and Malik, a well known problem in image segmentation. HNC identifies cells as coherent clusters of pixels that are highly distinct from the remaining pixels. HNCcorr guarantees a globally optimal solution to the underlying optimization problem as well as minimal dependence on initialization techniques. HNCcorr also uses a new method, called “similarity squared”, for measuring similarity between pixels in calcium-imaging movies. The effectiveness of HNCcorr is demonstrated by its top performance on the Neurofinder cell identification benchmark. We believe HNCcorr is an important addition to the toolbox for analysis of calcium-imaging movies.
FosbInduction in Nucleus Accumbens by Cocaine Is Regulated by E2F3a
Authors: Cates Hannah M. , Lardner Casey K. , Bagot Rosemary C. , Neve Rachael L. , Nestler Eric J.
Published: March 2019

The transcription factor ΔFosB has been proposed as a molecular switch for the transition from casual, volitional drug use into a chronically addicted state, but the upstream regulatory mechanisms governing ΔFosB expression are incompletely understood. In this study, we find a novel regulatory role for the transcription factor E2F3, recently implicated in transcriptional regulation by cocaine, in controlling ΔFosB induction in the mouse nucleus accumbens (NAc) following cocaine administration. We find that an E2F consensus sequence 500 bp upstream of theFosbtranscription start site is enriched for E2F3 specifically over other E2F isoforms. We further conclude that ΔFosB expression is regulated specifically by E2F3a, not E2F3b, thatE2f3aexpression is specific to D1 receptor-expressing medium spiny neurons, and that E2F3a overexpression in NAc recapitulates the induction ofFosbandΔFosbmRNA expression observed after chronic cocaine exposure. E2F3a knockdown in NAc does not abolishΔFosbinduction by cocaine, a result consistent with previously published data showing that singular knockdown of upstream regulators of ΔFosB is insufficient to block cocaine-induced expression. Finally, to elucidate potential combinatorial epigenetic mechanisms involved in E2F3a’s regulation ofFosb, we explore H3K4me3 enrichment at theFosbpromoter and find that it is not enhanced by E2F3a overexpression, suggesting that it may instead be a pre-existing permissive mark allowing for E2F3a to interact withFosb. Together, these findings support a role for E2F3a as a novel, upstream regulator of the addiction-mediating transcription factor ΔFosB in NAc.
Synaptic Basis for Contrast-Dependent Shifts in Functional Identity in Mouse V1
Authors: Yunzab Molis , Choi Veronica , Meffin Hamish , Cloherty Shaun L. , Priebe Nicholas J. , Ibbotson Michael R.
Published: March 2019

A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on the basis of their response linearity (Skottun et al., 1991). While the difference between cell classes is clear when the stimulus strength is high, reducing stimulus strength diminishes the differences between the cell types and causes some complex cells to respond as simple cells (Crowder et al., 2007; van Kleef et al., 2010; Hietanen et al., 2013). To understand the synaptic basis for this shift in behavior, we usedin vivowhole-cell recordings while systematically shifting stimulus contrast. We find systematic shifts in the degree of complex cell responses in mouse primary visual cortex (V1) at the subthreshold level, demonstrating that synaptic inputs change in concert with the shifts in response linearity and that the change in response linearity is not simply due to the threshold nonlinearity. These shifts are consistent with a visual cortex model in which the recurrent amplification acts as a critical component in the generation of complex cell responses (Chance et al., 1999).
Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome
Authors: Gulseth Hanne L , Gjelstad Ingrid M F , Tiereny Audrey C , McCarthy Danielle , Lovegrove Julie A , Defoort Catherine , Blaak Ellen E , Lopez-Miranda Jose , Dembinska-Kiec Aldona , Risérus Ulf , Roche Helen M , Drevon Christian A , Birkeland Kåre I
Published: March 2019

Objective

Impaired insulin secretion and action contribute to the development of type 2 diabetes. Dietary fat modification may improve insulin sensitivity, whereas the effect on insulin secretion is unclear. We investigated the effect of dietary fat modification on insulin secretion in subjects with the metabolic syndrome.

Design

In a 12-week pan-European parallel, randomized controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to four isoenergetic diets: high-fat diets rich in saturated fat (HSFA) or monounsaturated fat (HMUFA) or low-fat, high-complex carbohydrate diets with (LFHCC n-3) or without (LFHCC control) 1.2 g/day of n-3 PUFA supplementation. Insulin secretion was estimated as acute insulin response to glucose (AIRg) and disposition index (DI), modeled from an intravenous glucose tolerance test.

Results

There were no overall effect of the dietary intervention on AIRg and DI in the total cohort, in neither the high-fat nor LFHCC groups. We observed significant diet*fasting glucose category interactions for AIRg (P = 0.021) and DI (P = 0.001) in the high-fat groups. In subjects with normal fasting glucose and preserved first phase insulin secretion, the HMUFA diet increased, whereas the HSFA diet reduced AIRg (P = 0.015) and DI (P = 0.010).

Conclusions

The effects of dietary fat modification on insulin secretion were minor, and only evident in normoglycemic subjects. In this case, the HMUFA diet improved AIRg and DI, as compared to the HSFA diet.
Pituitary deficiency and precocious puberty after childhood severe traumatic brain injury: a long-term follow-up prospective study
Authors: Dassa Yamina , Crosnier Hélène , Chevignard Mathilde , Viaud Magali , Personnier Claire , Flechtner Isabelle , Meyer Philippe , Puget Stéphanie , Boddaert Nathalie , Breton Sylvain , Polak Michel
Published: March 2019

Objectives

Childhood traumatic brain injury (TBI) is a public health issue. Our objectives were to determine the prevalence of permanent pituitary hormone deficiency and to detect the emergence of other pituitary dysfunctions or central precocious puberty several years after severe TBI.

Design

Follow-up at least 5 years post severe TBI of a prospective longitudinal study.

Patients

Overall, 66/87 children, who had endocrine evaluation 1 year post severe TBI, were included (24 with pituitary dysfunction 1 year post TBI).

Main outcome measures

In all children, the pituitary hormones basal levels were assessed at least 5 years post TBI. Growth hormone (GH) stimulation tests were performed 3–4 years post TBI in children with GH deficiency (GHD) 1 year post TBI and in all children with low height velocity (<−1 DS) or low IGF-1 (<−2 DS). Central precocious puberty (CPP) was confirmed by GnRH stimulation test.

Results

Overall, 61/66 children were followed up 7 (5–10) years post TBI (median; (range)); 17/61 children had GHD 1 year post TBI, and GHD was confirmed in 5/17 patients. For one boy, with normal pituitary function 1 year post TBI, GHD was diagnosed 6.5 years post TBI. 4/61 patients developed CPP, 5.7 (2.4–6.1) years post-TBI. Having a pituitary dysfunction 1 year post TBI was significantly associated with pituitary dysfunction or CPP more than 5 years post TBI.

Conclusion

Severe TBI in childhood can lead to permanent pituitary dysfunction; GHD and CPP may appear after many years. We recommend systematic hormonal assessment in children 1 year after severe TBI and a prolonged monitoring of growth and pubertal maturation. Recommendations should be elaborated for the families and treating physicians.
PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans
Authors: Guran Tulay , Yesil Gozde , Turan Serap , Atay Zeynep , Bozkurtlar Emine , Aghayev AghaRza , Gul Sinem , Tinay Ilker , Aru Basak , Arslan Sema , Koroglu M Kutay , Ercan Feriha , Demirel Gulderen Y , Eren Funda S , Karademir Betul , Bereket Abdullah
Published: March 2019

Context

Most of the knowledge on the factors involved in human sexual development stems from studies of rare cases with disorders of sex development. Here, we have described a novel 46, XY complete gonadal dysgenesis syndrome caused by homozygous variants in PPP2R3C gene. This gene encodes B″gamma regulatory subunit of the protein phosphatase 2A (PP2A), which is a serine/threonine phosphatase involved in the phospho-regulation processes of most mammalian cell types. PPP2R3C gene is most abundantly expressed in testis in humans, while its function was hitherto unknown.

Patients and methods

Four girls from four unrelated families with 46, XY complete gonadal dysgenesis were studied using exome or Sanger sequencing of PPP2R3C gene. In total, four patients and their heterozygous parents were investigated for clinical, laboratory, immunohistochemical and molecular characteristics.

Results

We have identified three different homozygous PPP2R3C variants, c.308T>C (p.L103P), c.578T>C (p.L193S) and c.1049T>C (p.F350S), in four girls with 46, XY complete gonadal dysgenesis. Patients also manifested a unique syndrome of extragonadal anomalies, including typical facial gestalt, low birth weight, myopathy, rod and cone dystrophy, anal atresia, omphalocele, sensorineural hearing loss, dry and scaly skin, skeletal abnormalities, renal agenesis and neuromotor delay. We have shown a decreased SOX9-Phospho protein expression in the dysgenetic gonads of the patients with homozygous PPP2R3C variants suggesting impaired SOX9 signaling in the pathogenesis of gonadal dysgenesis. Heterozygous males presented with abnormal sperm morphology and impaired fertility.

Conclusion

Our findings suggest that PPP2R3C protein is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPPR3C provides insight into pathophysiology, as well as emerging as a potential therapeutic target for male infertility.
Thyroxine promotes lung cancer growth in an orthotopic mouse model
Authors: Latteyer S , Christoph S , Theurer S , Hönes G S , Schmid K W , Führer D , Moeller L C
Published: March 2019

Thyroid hormones are important for physiology and homeostasis. In addition to nuclear thyroid hormone receptors, the plasma membrane protein integrin αvβ3 has been recognized as a receptor for both thyroxine (T4) and triiodothyronine (T3). Here, we studied whether thyroid hormone promotes growth of murine lung cancer via αvβ3 in vivo. Murine Lewis lung carcinoma cells (3LL), stably transfected with luciferase, were injected into mouse lungs. Tumor growth in untreated mice was compared to hypothyroid mice and hypothyroid mice treated with T3 or T4 with or without the αvβ3 inhibitor 3,5,3′,5′-tetraiodothyroacetic acid (Tetrac). Tumor progression was determined by serial in vivo imaging of bioluminescence emitted from the tumor. Tumor weight was recorded at the end of the experiment. Neoangiogenesis was determined by immunohistochemistry for CD31. Tumor growth was reduced in hypothyroidism and increased by T4 treatment. Strikingly, only T4 but not T3 treatment promoted tumor growth. This T4 effect was abrogated by the αvβ3 inhibitor Tetrac. Tumor weight and neoangiogenesis were also significantly increased only in T4-treated mice. The T4 effect on tumor weight and neoangiogenesis was abolished by Tetrac. In vitro, T4 did not stimulate 3LL cell proliferation or signaling pathway activation. We conclude that T4 promotes lung cancer growth in this orthotopic mouse model. The tumor-promoting effect is mediated via the plasma membrane integrin αvβ3 and increased neoangiogenesis rather than direct stimulation of 3LL cells. These data suggest that such effects of levothyroxine may need to be considered in cancer patients on T4 substitution.
Fossiles lexicaux dans des expressions figées
Authors: Blanco Xavier
Published: March 2019

[full article and abstract in French, summary in English]

Un certain nombre d’unités lexicales du français qui ont disparu de l’usage se conservent, cependant, dans des expressions figées de différents types (locutions ou collocations surtout). Nous les appellerons « fossiles lexicaux ». C’est le cas, par exemple, de fur (dans au fur et à mesure), noise (dans chercher noise) ou coi (dans se tenir coi). Dans certains cas, c’est une acception particulière d’une unité lexicale donnée qui est conservée au sein d’une expression figée (par exemple soupe ‘tranche de pain arrossée de bouillon chaud’ dans trempé comme une soupe), donnant lieu parfois à des remotivations. Dans d’autres cas encore, c’est une forme morphologique (flexionnelle ou dérivationnelle) qui est préservée, par exemple vif dans plus mort que vif ou insu dans l’expression à l’insu de. Nous passerons en revue un certain nombre de ces expressions et nous donnerons des exemples du fonctionnement de ces formes dans des états de langue anciens.

Lexical Fossils in Frozen Expressions

A certain amount of French lexical units that have disappeared survive, nevertheless, in different kinds of frozen expressions (such as idioms or collocations). We call them « lexical fossils ». Some examples could be : fur (in au fur et à mesure), noise (in chercher noise) or coi (in se tenir coi). Sometimes it is a particular sense of a given lexical unit that persists inside a frozen expression (for example, soupe ‘slide of bread soaked in warm broth’ in trempé comme une soupe), giving rise occasionally to remotivations. In some other cases a morphological form (inflectional or derivational) is preserved, for instance vif in plus mort que vif or insu in à l’insu de. We will comment some of these expressions and we will give examples from different periods of French.
Study pada ZigBee Protocol
Authors: Muhammad Hasrul Ma’ruf Nurhayati,
Published: March 2019

Nowadays, Technology is growing rapidly, the one of example of technology, helps the human being to fulfill theirneed of information. The development of information technology and communication make the data  faster and also make the updating data easier for example protocols. The used of information and communication technology that is simple, automatic, low rate data and the lasting power has become imperative in accordance  with technological developments. In the field of wireless networking technology networks currently well addressed for this include Zigbeeprotocol. The technology in the specified ZigBee aimed at them. ZigBee is a specification for high-level communicationprotocol package that uses a small amount of low-power digital radios based on, the IEEE 802.15.4 standard for wireless personal area networks (WPANs). In this paper we discuss further on what and how Zigbee  is, how the relationship the IEEE and Zigbee are, who uses of Zigbee, how history of Zigbee is. What the hardware and softwareon Zigbee are, how it work as well as the type of Zigbee does. What the types of applications that use Zegbee are andhow usability Zigbe in general and home applications is. Keywords: Wireless Personal Area networks (WPAN)s, IEEE, Zigbee.
DIAGNOSA PENYAKIT GIGI DAN MULUT DENGAN MENGGUNAKAN PENDEKATAN SISTEM PAKAR
Authors: Budi Kurniawan Khodijah Hulliyah, Fitri Mintarsih,
Published: March 2019

Komputer pada era globalisasi saat ini menjadi kebutuhan utama dalam menunjang kerja-kerja manusia. Salah satu cabang ilmu komputer yang banyak dimanfaatkan oleh manusia untuk membantu kerjanya adalah pembentukan sistem pakar yang merupakan salah satu sub bidang ilmu kecerdasan buatan [1]. Salah satu pemanfaatan sistem pakar adalah dalam bidang kedokteran gigi. Terbukti dengan munculnya penelitian   I Nyoman Kusuma Wardana  bertajuk perancangan sistem pakar untuk diagnosa  penyakit mulut dan gigi menggunakan bahasa pemrograman CLIPS yang dipublikasikan pada  Seminar Nasional Aplikasi Teknologi Informasi  yang diadakan di Universitas Gajah Mada, Yogyakarta 21 Juni 2008. Aplikasi ini tampil dengan interface berupa pertanyaan-pertanyaan tertutup tentang gejala yang dirasakan oleh  user  sehingga tidak memaksimalkan hasil diagnosa yang didapat.  Sistem pakar ini juga menjadi pengembangan dari penelitian Bambang Suyono  (Seminar Nasional Informatika UPN Yogyakarta 22 Mei 2010) yang memiliki kekurangan pada penggunaan metode penelusuran depth first search sehingga tidak mampu menampilkan dua atau beberapa solusi  [3], padahal dalam mendiagnosa penyakit terkadang seorang dokter menetapkan diagnosa banding. Hal inilah yang mendorong penulis mengembangkan sistem aplikasi tersebut dengan memperbaiki segala kekurangan yang ada. Metode yang digunakan penelitian ini adalah  Extreme Programming  (XP) yang merupakan bagian dari metode AGILE  [7], terdiri dari lima tahap yaitu, Planning, Design, Coding, Test dan release [8]. Penelitian ini menggunakan software PHP versi 5.3.5 sebagai bahasa pemrograman, MYSQL versi 5.0.7 sebagai database dan keduanya terdapat dalam satu paket localhost XAMPP versi 1.7.4, sementara design aplikasi ini menggunakan Microsoft Office Front Page 2003. Sistem operasi yang digunakan penulis adalah Microsoft Windows Vista dan Personal Computer (PC) dengan spesifikasi, prosesor Intel Pentium Dual Core, RAM 1 GB dan Hard disk 160 GB. Kelebihan sistem pakar ini dari sistem sebelumnya adalah cakupan diagnosa penyakit gigi dan mulut yang lebih banyak, tampilan lebih interaktif  serta mampu menentukan diagnosa banding dari kedekatan gejala yang menyertai penyakit gigi dan mulut.Kata kunci: Extreme Programming (XP), Sistem Pakar, Penyakit Gigi dan Mulut
PEMANFAATAN TEKNOLOGI DALAM MENUNJANG IMPLEMENTASI GOOD GOVERNANCE DI BADAN LAYANAN UMUM PEMERINTAH
Authors: Fadhilah Mathar Fadhilah Mathar,
Published: March 2019

The research paper discusses about  the relationship between technology utilization and organization design with good governance in public service agency (badan  layanan umum/BLU). Public services institutions have been frequently impaired by corruption. Transforming the good governance principles in organization becomes a critical agenda to decrease the impact of such corruptive actions.Technology and organization design theoritically proposed as two of antecedent variables encouraging the acceleration of such transformation. The research paper is propositional paper. Keywords: good governance, information and communication technology, organization design,  public  service agency (badan layanan umum/BLU)
PERBANDINGAN QOS ROUTING PROTOCOL OLSR DAN GRP MENGGUNAKAN OPNET MODELER 14.5 PADA MOBILE AD HOC NETWORK
Authors: Andrew Fiade Siti Ummi Masruroh, Akmalul Mu’minin,
Published: March 2019

Mobile Ad hoc Network (MANET) merupakan suatu tipe jaringan wireless(ad hoc) yang menghubungkan node-node mobile, tanpa infrastruktur tetap atau infrastruktur yang ada sudah tidak bisa digunakan lagi sehingga mudah diaplikasikan dimana saja terutama pada kondisi darurat, seperti untuk keperluan militer, untuk evakuasi korban pada daerah bencana, dan sebagainya. Permasalahan pada MANET sendiri terdapat pada karakteristik jaringan yang dimilikinya, seperti: keterbatasan daya (karena menggunakan baterai), Mobilitas setiap node yang mampu bergerak ke segala arah,, dan otonomi setiap node dalam menentukan sendiri rute untuk meneruskan paket datanya.Maka dari permasalahan tersebut dibutuhkan  sebuah routing protocolyang mampu menangani kondisi jaringan pada MANET.Untuk mengetahui kualitas routing protocol, perlu dilakukan pengujian dan perbandingan.Pada penelitian ini akan diperbandingkan dua routing protocol yaitu OLSR dan GRP, dengan menggunakan OPNET Modeler 14.5 berdasarkan skenario simulasi. Hasil simulasi menunjukkan bahwa routing protocol OLSR memiliki performa yang lebih baik dibandingkan dengan GRP berdasarkan parameter delay, throughput dan data dropped.Delay OLSR sebesar 0.00046 second sedangkan GRP sebesar 0.00057 second. Untuk Throughput OLSR sebesar 1058 Kb/s  sedangkan GRP sebesar 69.3 Kb/s dan Data dropped tidak terjadi pada OLSR, sedangkan GRP terjadi sebesar 23.8846667 bits/sec.Kata Kunci: Mobile Ad-hoc Network, MANET,  OLSR, GRP, OPNET Modeler 14.5
APLIKASI PENGOLAHAN CITRA DIGITAL UNTUK PENDETEKSI JAWABAN PADA LEMBAR JAWABAN KOMPUTER MENGGUNAKAN ALGORITMA SOBEL (STUDI KASUS SMP NEGERI 2 KOTA BENGKULU)
Authors: Gita Triyana Asahar Johar, Desi Andreswari,
Published: March 2019

Lembar Jawaban Komputer (LJK) merupakan lembar jawaban yang digunakan untuk melakukan ujian secara tertulis. Pemeriksaan LJK harus menggunakan alat scanner khusus, mengingat harga scanner sangat mahal maka penulis bermaksud untuk membangun aplikasi pengolahan citra digital untuk mendeteksi jawaban pada lembar jawaban komputer menggunakan Algoritma Sobel. Metode Sobel merupakan pengembangan metode Robert dengan menggunakan filter HPF (High Pass Filter) yang diberi satu angka nol penyangga. Kelebihan dari metode Sobel ini adalah kemampuan untuk mengurangi noise sebelum melakukan perhitungan deteksi tepi.  Penulis mengubah data citra LJK menjadi bentuk deteksi tepi sobel untuk mempermudah mendeteksi jawaban pada LJK. Hasil deteksi jawaban pada LJK akan dilakukan pencocokkan dengan data kunci jawaban untuk memperoleh skor nilai. Selain itu laporan nilai siswa dapat ditampilkan secara otomatis menggunakan Fastreport. Aplikasi ini dibangun menggunakan bahasa pemrograman Delphi.dan  metode pengembangan sistem pada aplikasi ini menggunakan metodeWaterfall.Sedangkan metode untuk  perancangan sistem, penulis menggunakanUnified Modeling Language (UML). Hasil akhir dari penelitian ini adalah terciptanya suatu aplikasi pendeteksi  jawaban pada LJK yang dapatdigunakanmelakukan pengoreksian LJK.Kata kunci: Pengolahan Citra Digital, Sobel, LJK, Deteksi LJK.
APLIKASI PENJADWALAN MATA KULIAH MENGGUNAKAN ALGORITMA PARTICLE SWARM OPTIMIZATION (PSO)
Authors: Kusmarna Irfrans , Wardhani Luh Kesuma , Safrizal Muhammad
Published: March 2019

Tujuan dari penelitian ini adalah untuk membangun aplikasi penjadwalan kuliah menggunakan algoritma Particle Swarm Optimization  (PSO). Algoritma  ini dipilih  sebagai  algoritma yang digunakan dalam penelitian  ini karena algoritma  PSO  yang  merupakan  algoritma  heuristik,  adalah  salah  satu  metode  optimasi  yang  menggabungkan localsearch dan global search. Algoritma ini dapat memecahkan masalah dengan membentuk partikel-partikel pada populasi awal secara acak, mengevaluasi nilai  fitness, dan meng-update velocity serta posisi dari partikel. Dengan demikian diharapkan output yang dihasilkan merupakan kombinasi  terbaik dari serangkaian komponen yang ada. Kasus penjadwalan yang digunakan pada penelitian ini adalah penjadwalan mata kuliah di UIN Sultan Syarif Kasim Riau (UIN SUSKA). Permasalahan yang terjadi pada penjadwalan mata kuliah di UIN SUSKA Riau adalah tidak optimalnya pemenuhan beberapa contraint seperti keterbatasan ruangan. Dari hasil pengujian, aplikasi penjadwalan perkuliahan meggunakan algoritma PSO mampu menghasilkan  jadwal perkuliahan yang  sudah  tidak ada bentrok tetapi masih tidak memenuhi dari segi kualitas yaitu jam dimulainya perkuliahan inti yang difokuskan pada jam-jam yang efektif.Kata kunci: Constraint, Fitness,  Particle swarm optimizaton, Penjadwalan
NETWORK FORENSIC INVESTIGASI PADA STEGANOGRAFI
Authors: Bahaweres Rizal Broer , Tiaraningtias Hapsari , Kamil Putra Hadi , Khoirunnisya Khoirunnisya
Published: March 2019

Seiring dengan  semakin berkembangnya  teknologi  semakin bermunculan aplikasi  –  aplikasi yang memudahkan dalam melakukan  aktivitas. Dengan  bermunsulannya  Social Media  seperti Messenger,  setiap  orang  tidak  perlu bertatap muka untuk menyampaikan sesuatu. Hal ini berbanding lurus dengan semakin mudahnya bagi orang yang berniat jahat untuk melakukan aksinya. Tidak perlu bertemu langsung untuk merencanakan sesuatu, mereka dapat dengan  mudah  bertukar  informasi  melalu  Messenger  atau  aplikasi  lainnya.  Dengan  didukung  dengan  teknik kriptografi  yaitu  teknik  untuk menyembunyikan  pesan  dalam  suatu  file  seperti  teks,  foto  dan  lainnya,  bahkan sekarang kriptografi sudah berkembang dan muncul steganografi yaitu  teknik menyemunyikan pesan dalam  file berupa video atau audio, yang dapat memudahkan bagi pelaku kejahatan untuk berkomunikasi tanpa diketahui orang lain.Kata Kunci: Steganografi, Messenger, Social Media, Audio.
PERANCANGAN PROTOTYPE TAMPILAN ANTARMUKA PENGGUNA APLIKASI WEB KAMARDAGANG.COM DENGAN TEKNIK FLAT DESIGN PADA PT. SELARAS UTAMA INTERNASIONAL
Authors: Fauzia Syifa , Eka Fenty , Syaripudin Undang , Ichsani Yuditha
Published: March 2019

ABSTRAK Meskipun pertumbuhan e-commerce di Indonesia terbilang pesat namun tidak semua tampilan antarmuka pengguna aplikasi web e-commerce di Indoensia memiliki karakteristik yang user friendly. Padahal setiap user tentu mengharapkan tampilan antarmuka pengguna dengan kategori user experience yang memuaskan terutama dalam bidang e-commerce. Salah satu web e-commerce yang tampilan antarmuka penggunanya masih dibuat sederhana dan belum memenuhi kriteria user friendly yaitu kamardagang.com. Web tersebut milik PT. Selaras Utama Internasional yang menjadi tempat bagi penulis dalam melaksanakan penelitian, dengan melakukan perancangan prototype tampilan antarmuka pengguna terlebih dahulu pada web kamardagang.com tentunya dengan memanfaatkan kelebihan dari Flat Design diharapkan akan memudahkan para front end programmer untuk membangun suatu tampilan antarmuka aplikasi web yang sebenarnya dengan mengaplikasikan desain prototype yang telah dibuat. Di dalam paper ini telah dirancang Prototype Tampilan Antarmuka Pengguna Aplikasi Web Kamardagang.com dengan teknik Flat Design pada PT. Selaras Utama Internasional. Kata Kunci: flat design, user interface, website
La especificidad de la renta de la tierra en la industria petrolera desde una perspectiva marxiana
Authors: Fitzsimons Alejandro Luis
Published: March 2019

Este artículo destaca dos particularidades de la determinación y la apropiación de la renta de la tierra en la industria  petrolera. Primero, se señala que la no-renovabilidad del petróleo lleva a la preponderancia de las formas políticas y/o institucionales en el ejercicio de la propiedad de la tierra. Segundo, se sostiene que la distinción entre la propiedad del recurso y de la superficie genera una tendencia a la unificación de las funciones del capitalista y el terrateniente. Por último, se ilustran estas cuestiones esencialmente teóricas mediante un análisis de la industria petrolera global entre 1920 y 1970.
Determinantes del precio de la vivienda nueva en Medellín: un modelo estructural
Authors: García-Rendón John J. , Díaz Sebastían , Upegui Juan Carlos , Velásquez Hermilson
Published: March 2019

Esta investigación busca, mediante un modelo estructural, identificar los determinantes del precio de la vivienda nueva no VIS en Medellín, con el fin de explicar la formación de precios desde la organización industrial del sector. Los resultados indican que el empleo, el crecimiento económico y las políticas públicas (subsidios) influyen directamente -la inflación tiene injerencia negativa- sobre las condiciones del mercado de vivienda (CMV); simultáneamente, las CMV afectan la oferta y la demanda, fuerzas que, a su vez, inciden en la formación de los precios de mercado. Además, identifica la incidencia de las políticas públicas en el aumento de los precios.
Regresión cuantílica dinámica para la medición del valor en riesgo: Una aplicación a datos colombianos.
Authors: Melo Velandia Luis , Mariño Ustacara Daniel
Published: March 2019

En este documento se estima el valor en riesgo (VaR) utilizando métodos semiparamétricos basados en regresión cuantílica lineal y no lineal. En particular, se usan varias especificaciones de la familia de modelos CAViaR. Estos modelos permiten capturar hechos estilizados de las series financieras y evitan imponer supuestos relacionados con la distribución de los activos financieros. Adicionalmente, estas metodologías son comparadas con técnicas de VaR tradicionales para la tasa de cambio representativa del mercado, un índice de precios de bonos de deuda pública, y el índice de la bolsa de valores de Colombia, durante el periodo comprendido entre diciembre de 2007 y noviembre de 2015 . En general, se encontró que las medidas de riesgo de mercado bajo estas metodologías tienen un mejor desempeño respecto a las tradicionales.
Competencia, rendimientos crecientes y exceso de capacidad: la industria siderúrgica mundial (2000-2014)
Authors: Rodríguez Liboreiro Pablo
Published: March 2019

Tras quince años de expansión espoleada por una demanda vigorosa, la industria siderúrgica se enfrenta a un problema de exceso de capacidad que afecta a todos los grandes países productores del mundo. Ello se explica a partir de la fuerte competencia que ha caracterizado el desarrollo reciente del sector y que ha obligado a las empresas concurrentes a formar grandes reservas de capacidad para captar mercado frente a sus rivales y a explotar los rendimientos crecientes a escala para rebajar sus costes de producción. Así, la creciente exigencia en términos de escala mínima ha obligado a las empresas a acometer grandes expansiones de su capacidad para cumplir con los requisitos que marca la competencia a escala mundial. La contradicción entre un patrón de expansión como este, determinado por criterios de eficiencia, respecto de la pauta de la demanda de acero, típicamente cíclica, explica la formación de un gran exceso de capacidad en todo el mundo.
Impactos regionales y sectoriales de la política monetaria en Colombia
Authors: Quintero Otero Jorge David
Published: March 2019

En este artículo se realiza una estimación del impacto de la política monetaria sobre la producción en las regiones y sectores de la economía colombiana empleando un modelo de rezagos distribuidos en el que se combinan datos de producción regional y sectorial y una medida de choques de política monetaria estimada con datos del agregado de la economía. Los resultados obtenidos muestran que la política monetaria afecta en mayor medida las regiones Pacífico y Caribe y genera importantes diferencias sectoriales, que resultan ser determinantes en la transmisión regional de la política monetaria mediante el canal de tasa de interés.
La disposición al pago para la conservación de bienes patrimoniales: Caso del Centro Histórico de la Ciudad de Quito
Authors: Chafla Martinez Pablo
Published: March 2019

Esta investigación tiene como objetivo aportar en el estudio y la valoración de los bienes que forman parte del patrimonio histórico, que es un tema poco estudiado por la ciencia económica. En este caso, y para poder valorar la importancia que la conservación del centro histórico de Quito tiene en el bienestar de los residentes de la ciudad y en los turistas que la visitan, se utilizó una metodología de valoración económica de intangibles, como la valoración contingente, para determinar la disposición al pago de los usuarios directos de este bien patrimonial para un proyecto de conservación.
Intergenerational educational mobility in Latin America. An analysis from the equal opportunity approach
Authors: Jiménez Maribel , Jiménez Mónica
Published: March 2019

The objective of this study is to examine intergenerational educational mobility (IEM) in Latin America from the equal opportunity (EOP) approach. To this end, using the Latinobarómetro survey, a new technique is applied to measure the degree of overlap between the observed joint density of parents’ and children’s educational levels and the theoretical density corresponding to an EOP situation. The main results show a significant increase in mean IEM levels. However, there is no improvement in EOP measures among children of parents with the lowest levels of education.
Lacrimal gland adenoma in a sheep
Authors: Farjanikish G. , Khodakaram-Tafti A. , Ghane M.
Published: March 2019

The lacrimal gland is a diamond-shaped, tubuloalveolar gland that secretes the serous component of tears. A four-year-old female crossbreed sheep suffering from left eye protrusion was referred to a Veterinary Hospital. Ophthalmic examination revealed epiphora, superficial ulcerative keratitis, corneal edema and neovascularisation. Moreover, ultrasound examination showed a large heterogeneous mass with variable reflectivity in the intraconal and extraconal spaces. Grossly, a 2.5×1.5×0.5 cm oval firm grayish mass was observed. Histopathologically, the mass was composed mainly by tubules with two cell types including cuboidal luminal epithelial cells and peripheral myoepithelial cells. The tubular structures were separated by proliferating myoepithelial cells. Mitotic figures, cellular pleomorphism
and atypia were not seen. Immunohistochemically, most of the luminal epithelial cells
showed an immunopositive reaction with a cytokeratin (AE1/AE3) marker. On the basis of these findings, the mass was diagnosed as a lacrimal gland adenoma.
Protein and lipid species in seminal plasma of fertile Holstein-Friesian bulls
Authors: Almadaly E. A , Farrag F. A. , Nasr N. El.
Published: March 2019

Protein and lipid molecules in seminal plasma (SP) collected from fertile bulls were investigated. Semen was collected from 10 bulls (2 ejaculates each) and examined for standard semen analysis. Raw SP was recovered by centrifugation and total protein (TP) concentration was determined using a refractometer. Raw SP was desalted using a Sephadex G-25 desalting column then both raw and desalted SP was subjected to SDS-PAGE. Neutral lipids and phospholipids of raw and desalted SP were separated by thin-layer chromatography (TLC). The results revealed that, all bulls had normal semen characteristics and TP concentration in SP ranged from 7.0 to 10.4 g/dL except bull No. 6 had a relatively low concentration of 4.9 to 6.8 g/dL. Neither proteins nor lipids species were different between raw and desalted SP. Seventeen proteins were detected ranging from 8.5 to 185.8 kDa, and those of 12, 13.5, 15, 21, 23 and 38 kDa were predominant. Notably, proteins of 10, 17.5, 19, 21, 80 and 185.8 kDa might be new candidates of SP proteins (SPPs). The detected neutral lipid spots corresponded to cholesterol, 1,2-dimyristoyl glycerol, 1,2-dioleoyloglycerol, 1,3-dimyristoyl glycerol and 1,3-dioleoyloglycerol. The detected phospholipids spots corresponded to non-migrating phospholipids, sphingomyelin (SM), phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylethanolamine (PE), cerebroside and polyglycerol phosphatide. Cholesterol represents the major molecule of neutral lipids, whereas SM, PC, PI and PE represent the major phospholipids. Noteworthy, there were 2 species of diacylglycerol (DAG) and 3 species of PI in bovine SP. In conclusion, this study gave a general picture of SP protein and lipid species in fertile bull semen, which might serve as fundamental knowledge for either semen analysis or prediction of male fertility.
Analgesic and sedative effects of caudal epidural tramadol in dromedary camels
Authors: Azari O. , Seyyedin S. , Molaei M. M. , Hassibi H. , Madani B. Hashemi
Published: March 2019

This study aimed to investigate the analgesic efficacy of caudal epidural administration of tramadol in dromedary camels (Camelus dromedarius). A total of 10 dromedary camels of both sexes were selected and randomly assigned to one of two groups to receive epidurally either 1 mg/kg or 2 mg/kg of tramadol hydrochloride. The injections were made into the epidural space at first intercoccygeal junction. Using a pinprick method, analgesia was tested. Duration and onset of complete perineal analgesia were determined. Ataxia and sedation were also assessed and recorded. Clinical parameters including heart rate, respiratory rate and rectal temperature were measured. The lower dose (1 mg/kg) of tramadol induced analgesia only in the tail but the higher dose produced complete antinociception in the tail, anus and perineum. Analgesia of the hind limbs was not achieved after either doses of tramadol. The mean times to onset and duration of complete analgesia in camels receiving epidural tramadol at a dose of 2 mg/kg were 22±2.55 min and 65±8.66 min, respectively. Various degrees of ataxia occurred in all camels. Mild to deep sedation was observed following both doses. Mean heart rate, respiratory rate, and rectal temperature tended to increase for the first 15 or 30 min after injection. Based on the results of this study, analgesic effects of caudal epidural tramadol were dose dependent. Epidural tramadol at a dose of 2 mg/kg would provide suitable postoperative analgesia for various manipulations in the tail, anus and perineum in standing dromedary camels.
Analisis Strategi Penjualan Stok Spare Part di PT. Fajar Mas Murni Surabaya
Authors: Purwanti Ida , Farida Yuniar
Published: March 2019

Penelitian ini menggunakan studi kasus pada PT Fajar Mas Murni Surabaya yang bertujuan untuk mengklasifikasikan masing-masing item stok spare part dengan pendekatan matriks BCG  guna menentukan strategi penjualan stok item spare part. Hasil klasifikasi dengan matriks BCG diperoleh 6.60% item termasuk dalam kuadran stars yang menyumbang omzet 80.67% bagi perusahaan, 15.57% item termasuk dalam kuadran question marks yang menyumbang omzet 14.95% bagi perusahaan, 71.70% item termasuk dalam kuadran dogs yang menyumbang omzet hanya 1.87% bagi perusahaan,  dan 6.13% termasuk dalam kuadran cash cows yang menyumbang omzet 2.50% bagi perusahaan. Analisis strategi yang sebaiknya dilakukan pada kuadran stars adalah dengan melakukan forecasting penjualan untuk menjaga kontinuitas stok spare part, pada kuadran question marks yang sebaiknya dilakukan adalah mengembangkan nilai penjualan dengan menjual item secara diskon agar terjadi peningkatan volume penjualan dan dapat menghabiskan stok, sedangkan pada kuadran dogs alternatif strategi yang sebaiknya dilakukan adalah lebih meningkatkan kegiatan promosi dari item-item tersebut, dan pada kuadran cash cows adalah dengan mempertahankan penjualan. Kemudian dilakukan forecasting penjualan pada item stok spare part kuadran stars tahun 2018 agar tetap terjaga kontinuitasnya dengan menggunakan metode trend (T) rata-rata bergerak dengan variasi siklus (C), variasi musim (S), dan gerak tak beraturan (I) karena memberikan nilai MAPE yang lebih kecil yaitu 23% dan 27% ketika hanya menggunakan metode trend.
Pemodelan Kriminal di Jawa Timur dengan Metode Geographically Weighted Regression (GWR)
Authors: Nurhuda Imanudin , Jaya I Gede Nyoman Mindra
Published: March 2019

Criminality constitutes all kinds of actions that are economically and psychologically harmful in violation of the law applicable in the state of Indonesia as well as social and religious norms, while the criminal data is the number of cases reported to the police institution. The higher the number of complainants the higher the number of criminals in the region. The greater the risk the community represents the more insecure a region is. This study aims to obtain the best model affecting crime or crime in East Java. The number of crimes in this study is limited to the number of theft cases (whether ordinary theft, theft by force, theft with theft, and the theft of motor vehicles). In this study, we use the Geographically Weighted Regression (GWR) model because this method is quite effective in estimating data that has spatial heterogeneity (uniformity in location / spatial). In essence, the model parameters in GWR can be calculated at the observation location with the dependent variable and one or more independent variables that have been measured at the sites where the location is known, where criminal acts in the research conducted in East Java involves the effects of spatial heterogeneity, with fixed kernel weighting function. The results showed that the variables affecting criminality in East Java Province are population density, economic growth, Gini Ratio, and poverty.