bluuebunny/crossref_metadata_2025 huggingface dataset:
3D-Printed Lithium-Ion Battery Electrodes: A Brief Review of Three Key Fabrication Techniques
Authors: Pavlovskii Alexander A. , Pushnitsa Konstantin , Kosenko Alexandra , Novikov Pavel , Popovich Anatoliy A.
Published: December 2024

In recent years, 3D printing has emerged as a promising technology in energy storage, particularly for the fabrication of Li-ion battery electrodes. This innovative manufacturing method offers significant material composition and electrode structure flexibility, enabling more complex and efficient designs. While traditional Li-ion battery fabrication methods are well-established, 3D printing opens up new possibilities for enhancing battery performance by allowing for tailored geometries, efficient material usage, and integrating multifunctional components. This article examines three key 3D printing methods for fabricating Li-ion battery electrodes: (1) material extrusion (ME), which encompasses two subcategories—fused deposition modeling (FDM), also referred to as fused filament fabrication (FFF), and direct ink writing (DIW); (2) material jetting (MJ), including inkjet printing (IJP) and aerosol jet printing (AJP) methods; and (3) vat photopolymerization (VAT-P), which includes the stereolithographic apparatus (SLA) subcategory. These methods have been applied in fabricating substrates, thin-film electrodes, and electrolytes for half-cell and full-cell Li-ion batteries. This discussion focuses on their strengths, limitations, and potential advancements for energy storage applications.
Optimizing Cement Content in Controlled Low-Strength Soils: Effects of Water Content and Hydration Time
Authors: Luo Yilian , Jiang Liangwei , Qin Libing , Luo Qiang , Connolly David P. , Wang Tengfei
Published: December 2024

The Ethylene Diamine Tetra-acetic Acid (EDTA) titration test is widely used for determining cement content, but its reliability is influenced by the hydration process of cement, which is affected by factors such as water content and hydration time. Despite their importance, these factors have received limited attention in existing research. This study explores the relationships between the volume of titrant required for stabilization, cement content, water content, and hydration time. Using a regression orthogonal test, the primary and secondary relationships, as well as the interdependencies among these factors, are analyzed. Results reveal a negative linear relationship between the titrant volume and both water content and hydration time. Cement content, water content, and hydration time are identified as the most significant factors, with minimal interdependencies observed. Within the test parameters, calculated values exhibit an error margin below 2.4%. Deviations of 2.9% in water content and 86 min in hydration time correspond to an approximate 0.5% change in cement content. These findings offer valuable insights for optimizing cement content detection in Controlled Low-Strength Material (CLSM) mixes, promoting more sustainable construction practices.
Materials Nanoarchitectonics for Advanced Devices
Authors: Ariga Katsuhiko
Published: December 2024

Advances in nanotechnology have made it possible to observe and evaluate structures down to the atomic and molecular level. The next step in the development of functional materials is to apply the knowledge of nanotechnology to materials sciences. This is the role of nanoarchitectonics, which is a concept of post-nanotechnology. Nanoarchitectonics is defined as a methodology to create functional materials using nanounits such as atoms, molecules, and nanomaterials as building blocks. Nanoarchitectonics is very general and is not limited to materials or applications, and thus nanoarchitecture is applied in many fields. In particular, in the evolution from nanotechnology to nanoarchitecture, it is useful to consider the contribution of nanoarchitecture in device applications. There may be a solution to the widely recognized problem of integrating top-down and bottom-up approaches in the design of functional systems. With this in mind, this review discusses examples of nanoarchitectonics in developments of advanced devices. Some recent examples are introduced through broadly dividing them into organic molecular nanoarchitectonics and inorganic materials nanoarchitectonics. Examples of organic molecular nanoarchitecture include a variety of control structural elements, such as π-conjugated structures, chemical structures of complex ligands, steric hindrance effects, molecular stacking, isomerization and color changes due to external stimuli, selective control of redox reactions, and doping control of organic semiconductors by electron transfer reactions. Supramolecular chemical processes such as association and intercalation of organic molecules are also important in controlling device properties. The nanoarchitectonics of inorganic materials often allows for control of size, dimension, and shape, and their associated physical properties can also be controlled. In addition, there are specific groups of materials that are suitable for practical use, such as nanoparticles and graphene. Therefore, nanoarchitecture of inorganic materials also has a more practical aspect. Based on these aspects, this review finally considers the future of materials nanoarchitectonics for further advanced devices.
Analysis of Liquid Sweat Transport in Underwear Combined with Multilayer Fabric Assemblies for Firefighter Outfits
Authors: Matusiak Małgorzata , Sukhbat Otgonsuren
Published: December 2024

A firefighter’s outfit consists of several layers with distinct properties and functions. These layers serve as barriers against external hazards but also impede the transport of sweat generated by the human body. As a result, sweat vapor often fails to transfer effectively from the body through the firefighter’s protective clothing (FPC) to the environment. This can lead to sweat condensation on the firefighter’s skin, causing discomfort. To enhance the physiological comfort of firefighters during firefighting and other rescue operations, it is essential to consider the transport of condensed sweat within the multilayer textile system comprising both the underwear and the FPC. In this study, 16 assembly variants were tested, combining four types of knitted fabrics for underwear with four types of multilayer textile sets designed for FPC. The liquid moisture transport properties of these assemblies were evaluated using the Moisture Management Tester (MMT290), an innovative instrument manufactured by SDL Atlas. The results demonstrated that the knitted fabrics effectively transport liquid sweat, whereas in the case of multilayer textile sets for FPC, liquid sweat transport is primarily confined to the inner layer adjacent to the skin. Furthermore, the findings indicate that by selecting an appropriate combination of knitted fabric for underwear and the inner layer of the FPC, it is possible to optimize liquid moisture transport in a firefighter’s outfit.
Isolation and Characterization of Bioactive Compounds from Saccharomonospora sp. CMS18 and Their Antifungal Properties
Authors: Um Soohyun , Jeong Hyeongju , Park Ji-Eun , Seo Jeongwon , Jung Sang Heon , Bae Munhyung , Lee Kyung-Tae , Moon Kyuho
Published: December 2024

In this study, metagenomic analysis was employed to investigate the bacterial communities in the Muan tidal mudflat of the Republic of Korea. We used metagenomic analysis to identify the microbial community in tidal soil dominated by Proteobacteria. From this environment, the bacterial strain, Saccharomonospora sp. CMS18, was isolated and yielded two previously unknown compounds, penipaline D (3) and N-acetyl-dimethylallyltryptophan (4). The chemical structures of the isolated compounds along with 6-dimethylallyl-indole (1), 6-dimethylallyltryptophan (2), penipaline D (3), and N-acetyl-dimethylallyltryptophan (4) were structurally investigated using HR-ESI-MS and NMR spectroscopy. The isolated compound 6-dimethylallyl-indole (1) demonstrated broad-spectrum antifungal activity, with IC50 value of 0.04 mM against Candida glabrata and 0.35 mM against both Candida albicans and Cryptococcus neoformans. Additionally, it exhibited additive interaction with caspofungin against C. albicans.
Magnetoelectric BAW and SAW Devices: A Review
Authors: Luo Bin , Velvaluri Prasanth , Liu Yisi , Sun Nian-Xiang
Published: December 2024

Magnetoelectric (ME) devices combining piezoelectric and magnetostrictive materials have emerged as powerful tools to miniaturize and enhance sensing and communication technologies. This paper examines recent developments in bulk acoustic wave (BAW) and surface acoustic wave (SAW) ME devices, which demonstrate unique capabilities in ultra-sensitive magnetic sensing, compact antennas, and quantum applications. Leveraging the mechanical resonance of BAW and SAW modes, ME sensors achieve the femto- to pico-Tesla sensitivity ideal for biomedical applications, while ME antennas, operating at acoustic resonance, allow significant size reduction, with high radiation gain and efficiency, which is suited for bandwidth-restricted applications. In addition, ME non-reciprocal magnetoacoustic devices using hybrid magnetoacoustic waves present novel solutions for RF isolation, which have also shown potential for the efficient control of quantum defects, such as negatively charged nitrogen-vacancy (NV−) centers. Continued advancements in materials and device structures are expected to further enhance ME device performance, positioning them as key components in future bio-sensing, wireless communication, and quantum information technologies.
Synthesis and Investigation of the Properties of a Branched Phthalonitrile Containing Cyclotriphosphazene
Authors: Ren Dengxun , Fan Zexu , Zhang Jiaqu , Xu Yi , Tang Xianzhong , Xu Mingzhen
Published: December 2024

To study the properties of cyclotriphosphazene (CTP)-containing phthalonitriles, a branched phthalonitrile containing CTP (CTP–PN) with self-catalytic behavior was designed and synthesized. The structure of CTP–PN was characterized by FT–IR (Fourier transform infrared spectroscopy), MS (mass spectroscopy), 1H–NMR (proton nuclear magnetic resonance spectroscopy), and 13C–NMR (carbon nuclear magnetic resonance spectroscopy). Then, the curing reaction of CTP–PN was studied using DSC (differential scanning calorimetry) and DRA (dynamic rheological analysis). The results show that the curing reaction of CTP–PN is initiated at 200 °C. Additionally, the change in the viscosity of CTP–PN as a function of the temperature was investigated. After curing at different temperatures, the generated structures were characterized by FT–IR. The fracture morphology and thermomechanical properties of cured CTP–PN were scanned and studied using SEM (scanning electron microscopy) and TMA (thermomechanical analysis), respectively. The results demonstrate that CTP–PN exhibits a smooth fracture surface and possesses a relatively low CTE (coefficient of linear thermal expansion) of approximately 25 ppm/°C at 285 °C. A Td5% (temperature at which 5% weight loss occurs) of as high as 405 °C can be obtained for cured CTP–PN, and its char yield at 800 °C exceeds 70% in N2. FT–IR and XPS (X-ray photoelectron spectroscopy) were used to study the thermal decomposition of cured CTP–PN, indicating that it remains stable below 350 °C. With an increasing temperature, there is decomposition first of CTP and P–NH–Ph and C–O–C bonds (>350 °C) and then nitrogen-containing aromatic heterocycles (>500 °C), ultimately resulting in the formation of P-containing residual char.
Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)2 and Application in Late-Stage Drug Functionalization
Authors: Kathiravan Subban , Dhillon Prakriti , Zhang Tianshu , Nicholls Ian A.
Published: December 2024

Unsymmetrical urea derivatives are essential structural motifs in a wide array of biologically significant compounds. Despite the well-established methods for synthesizing symmetrical ureas, efficient strategies for the synthesis of unsymmetrical urea derivatives remain limited. In this study, we present a novel approach for the synthesis of unsymmetrical urea derivatives through the coupling of amides and amines. Utilizing hypervalent iodine reagent PhI(OAc)2 as a coupling mediator, this method circumvents the need for metal catalysts, high temperatures, and inert atmosphere. The reaction proceeds under mild conditions and demonstrates broad substrate scope, including various primary and secondary amines and primary benzamides. This protocol not only offers a practical and versatile route for synthesizing unsymmetrical ureas but also shows significant potential for the late-stage functionalization of complex molecules in drug development.
The Elusive Biological Activity of Scorpionates: A Useful Scaffold for Cancer Therapy?
Authors: Petrosian Artem , Pinheiro Pedro F. , Ribeiro Ana P. C. , Martins Luísa M. D. R. S. , Justino Gonçalo C.
Published: December 2024

Cancer remains a formidable challenge, requiring the constant pursuit of novel therapeutic agents and strategies. Scorpionates, known for their unique coordination properties, have recently gained attention for their anticancer potential. Traditionally applied in catalysis, these compounds have demonstrated notable cytotoxicity across various cancer cell lines, often surpassing the efficacy of conventional chemotherapeutics. This review addresses recent findings on scorpionate complexes, emphasizing the impact of metal choice and ligand design on biological activity. Copper and ruthenium scorpionates show promise, leveraging redox activity and mitochondrial disruption mechanisms to selectively induce cancer cell death. Ligand modifications, including sulfur-containing heterocycles and unsubstituted pyrazoles, have proven effective in enhancing cytotoxicity and selectivity. Furthermore, dipodal ligands show unique potential, with selective binding sites that improve stability and facilitate specific cellular interactions, such as targeting metastatic pathways. These findings highlight the largely unexplored potential of scorpionate complexes, positioning them as candidates for next-generation anticancer therapies. Continued research into structure–activity relationships and precise mechanisms of action could pave the way for developing highly potent and selective anticancer agents based on scorpionate chemistry.
Nutritional Value and Therapeutic Benefits of Dragon Fruit: A Comprehensive Review with Implications for Establishing Australian Industry Standards
Authors: Chen Si-Yuan , Xu Cheng-Yuan , Mazhar Muhammad Sohail , Naiker Mani
Published: December 2024

Dragon fruit, which is native to northern South America and Mexico, has become a significant crop in tropical and subtropical regions worldwide, including Vietnam, China, and Australia. The fruit (Hylocereus spp.) is rich in various bioactive phytochemical compounds, including phenolic acids, flavonoids, and pigments such as betalains and anthocyanins, which contribute to its antioxidant, anti-inflammatory, and anti-microbial properties. This comprehensive review introduces the origin, classification, and global production of dragon fruit, with a particular focus on its bioactive phytochemicals and therapeutic potential. Additionally, it critically evaluates the current industry standards for fresh dragon fruit production across key producing countries. While these standards primarily focus on quality, classification, and grading criteria, they lack focus on parameters related to the fruit’s bioactive content. The absence of established quality standards for fresh produce in the Australian dragon fruit industry presents a unique opportunity to develop guidelines that align with both international benchmarks and the therapeutic potential of the fruit. By addressing this gap, this review can potentially help Australia to position its dragon fruit industry to achieve greater consistency, competitiveness, and consumer appeal. As the demand for functional foods continues to rise, aligning Australian production practices with global standards becomes critical to meeting domestic market expectations. This review provides a comprehensive understanding of dragon fruit’s nutritional and therapeutic significance and highlights its potential role in establishing a robust standard for the Australian dragon fruit industry. A review of global industry standards reveled that Australian standard could incorporate classifications of dragon fruits, including external factors like appearance, size, and defect tolerance. Future research is needed to prioritize understanding of the impact of cultivation practices and environmental factors on the bioactive composition of dragon fruit, enabling the development of best practices for growers. Additionally, further studies are needed to evaluate the therapeutic effects of these bioactive properties through clinical trials, particularly their potential in preventing chronic diseases. The advancement of analytical methods for quantifying bioactive compounds will provide deeper insights into their health benefits and support the establishment of bioactive-oriented industry standards. Moreover, investigations of post-harvest handling and processing techniques could optimize the preservation of these valuable compounds, enhancing dragon fruit’s role as a functional food.
Green Synthesis of Silver Nanoparticles (CM-AgNPs) from the Root of Chuanminshen for Improving the Cytotoxicity Effect in Cancer Cells with Antibacterial and Antioxidant Activities
Authors: Wang Dandan , Ke Haijing , Wang Hongtao , Shen Jingyu , Jin Yan , Lu Bo , Wang Bingju , Li Shuang , Li Yao , Im Wan Taek , Siddiqi Muhammad Zubair , Zhu Haibo
Published: December 2024

The unique properties of silver nanoparticles (AgNPs), such as size, surface charge, and the ability to release silver ions, contribute to DNA damage, inducing of oxidative stress, and apoptosis in cancer cells. Thus, the potential application of AgNPs in the field of biomedicine, and cancer therapy are rapidly increasing day by day. Therefore, in this study, AgNPs were synthesized by extract of Chuanminshen violaceum, and then the synthesized CM-AgNPs were fully characterized. The biological activity of CM-AgNPs was investigated for antibacterial, antioxidant, and anticancer activities. The cytotoxic activity of CM-AgNPs was tested for various kinds of cancer cells including MKN45 gastric cancer cells, HCT116 human colon cancer cells, A549 human lung cancer cells, and HepG2 liver cancer cells. Among these cancer cells, the induced apoptosis activity of CM-AgNPs on HCT116 cancer cells was better and was used for further investigation. Besides, the CM-AgNPs exhibited great antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with 50% free radical scavenging activity, and CM-AgNPs also showed a significant antibacterial activity against Escherichia coli and Staphylococcus aureus. Thus, our pilot data demonstrated that the green synthesis of CM-AgNPs would be considered a good candidate for the treatment of HCT116 cancer cells, with its strong antioxidant activity and antibacterial effects.
Antiplatelet, Anticoagulant, and Fibrinolytic Activity of Orchids: A Review
Authors: Fernández-Rojas Berenice , López-Pérez Abimael , Lagunez-Rivera Luicita , Solano Rodolfo , Bernal-Martínez Anel Karina , Majluf-Cruz Abraham , Hernández-Juárez Jesús
Published: December 2024

Thrombosis is the occlusion of a blood vessel and is responsible for the highest number of deaths worldwide. Its treatment comprises the use of anticoagulants, antiplatelets, and thrombolytics. Although many antithrombotic drugs are currently available, none is completely effective and safe. Plants are a valuable source of compounds with antithrombotic properties. Some orchid species have been used in traditional medicine for their antithrombotic properties. This review informs about the contribution of orchids in this field and the studies that have validated their properties.
The Relationship Between Body Composition Parameters and the Intake of Selected Nutrients, and Serum Anti-Müllerian Hormone (AMH) Levels in the Context of Ovulatory Infertility
Authors: Skowrońska Magdalena , Pawłowski Michał , Buczyńska Angelika , Wiatr Aleksandra , Dyszkiewicz Aleksandra , Wenta Aleksandra , Gryko Kamila , Zbucka-Krętowska Monika , Milewski Robert
Published: December 2024

Background/Objective: The aim of this study was to outline the relationships between selected parameters connected with lifestyle and serum anti-Müllerian hormone (AMH) levels, i.e., a marker of ovarian reserve. By examining AMH levels in connection with nutrient intake and body composition parameters, this study aimed to provide a preliminary background for further studies focused on establishing dietary and lifestyle recommendations that could lead to improvements in fertility outcomes. Methods: The research involved 28 women, aged 26 to 42—both with and without ovulatory infertility—who were patients of the Reproductive Health Clinic at the Medical University of Białystok. The participants underwent a number of tests consisting of hormonal profiling, including AMH measurements, body composition analyses, and dietary assessments based on a 3-day food diary. Results: The findings of the study indicate that certain lifestyle factors are associated with changes in AMH levels. Most importantly, the multivariate linear regression model designed in the study shows that age, waist-to-hip ratio (WHR), as well as the intake of sucrose, iodine, and erucic acid explain variations in serum AMH levels. These results support the hypothesis that modifiable lifestyle factors can influence AMH levels, and thus ovarian reserve. Conclusions: The study underscores the potential for targeted lifestyle interventions to support fertility and calls for further research in the form of prospective studies performed in larger groups of patients to substantiate these associations and inform fertility care strategies. Based on the preliminary results of this study, certain dietary ideas that could positively influence fertility have been proposed, focused on the normalization of body weight and the reduction in excess fat tissue.
The Oral Bioavailability of Vitamin B12 at Different Doses in Healthy Indian Adults
Authors: Kashyap Sindhu , Gowda Poorvikha , Pasanna Roshini M. , Sivadas Ambily , Sachdev Harshpal S. , Kurpad Anura V. , Devi Sarita
Published: December 2024

Background/Objectives: The bioavailability of crystalline vitamin B12 (B12) through active absorption is reported to have a maximum capacity of 1.5–2.5 µg per dose. A small passive bioavailability has also been suggested at high doses. The present study aimed to determine the dose-dependency of active B12 absorption and to quantify its passive absorption at higher doses. Methods: The dose-dependency of crystalline B12 bioavailability was determined in nine healthy adults, using oral [13C]-cyanocobalamin, in a cross-over design at doses of 2.5, 5, and 10 µg. The dose order was randomised, with a washout of one month. Literature data from was added to the present study data in a meta-analysis of the relation between B12 bioavailability and dose, to evaluate its pattern at different doses. Results: Bioavailability, as a function of dose, was significantly different between 2.5, 5, and 10 µg doses of [13C]-cyanocobalamin at 50.9 ± 32.5%, 26.7 ± 22.3%, 15.4 ± 13.6%, respectively, (p < 0.01), while the absolute bioavailability trended upward, at 1.16 ± 0.74 µg, 1.22 ± 1.02 µg, and 1.39 ± 1.23 µg (p = 0.46). The meta-analysis showed two distinct phases of bioavailability. Up to a dose of 2.6 µg, there was a significant steep positive correlation, with a slope (bioavailability) of 43%/µg suggesting an active process with a maximum of 1.2 µg. At higher doses, the slope was 1%/µg, not significantly different from zero, possibly a passive process. Conclusions: The active bioavailability of crystalline B12 is not dose-dependent, saturating at ~1.2 µg.
Examination of Energy Needs and Low Energy Availability Among Historically Black College and University Female Student-Athletes
Authors: Uriegas Nancy A. , Emerson Dawn M. , Winkelmann Zachary K. , Ortaglia Andrew , Torres-McGehee Toni M.
Published: December 2024

Low energy availability (LEA) is common among female student-athletes and contributes to reduced bone mineral density and hormonal dysfunction. However, limited research exists on student-athletes of color, making it difficult to generalize results across populations, particularly Historically Black Colleges and Universities (HBCUs) student-athletes. Objectives: This study examined the energy needs and LEA prevalence, with or without eating disorder (ED) risk, among HBCU female student-athletes. Methods: Twenty-seven female student-athletes (age = 19 ± 1 year; height = 166.9 ± 7.6 cm; weight = 68.8 ± 11.3 kg) completed baseline measures, including the Eating Disorder Inventory-3 (EDI-3), EDI-3 symptom checklist (EDI-SC), anthropometric measures, and resting metabolic rate (RMR). Participants maintained a dietary log to measure energy intake and wore a heart rate monitor to estimate exercise energy expenditures for 7 days. LEA was defined as <30 kcal/kg of fat-free mass (FFM)/day. Results: The mean energy availability (15.9 ± 10.1 kcal/kg FFM/day) indicated 92.6% of participants (n = 25) displayed LEA; of those, 60% (n = 15) had LEA with ED risk. ED risk was identified in 59.3% of student-athletes (n = 13; EDI-3: n = 2; SC: n = 3; Both: n = 11). Interestingly, of the two student-athletes without LEA, one was identified at risk for EDs using both the EDI-3 and SC. Conclusions: HBCU female student-athletes face high risks of LEA and EDs, with most showing signs of both. This underscores the need for culturally sensitive interventions to improve EA and support mental health in this underserved group. Clinicians should focus on nutrition education and early ED identification to enhance long-term health and athletic performance.
The Effectiveness of the Low-Glycemic and Insulinemic (LOGI) Regimen in Maintaining the Benefits of the VLCKD in Fibromyalgia Patients
Authors: Castaldo Giuseppe , Marino Carmen , D’Elia Maria , Grimaldi Manuela , Napolitano Enza , D’Ursi Anna Maria , Rastrelli Luca
Published: December 2024

Background: Fibromyalgia (FM) is a chronic disorder that causes damage to the neuro-muscular system and alterations in the intestinal microbiota and affects the psychological state of the patient. In our previous study, we showed that 22 women patients subjected to a specific very low-carbohydrate ketogenic therapy (VLCKD) showed an improvement in clinical scores as well as neurotransmission-related and psychological dysfunctions and intestinal dysbiosis. Furthermore, NMR metabolomic data showed that changes induced by VLCKD treatment were evident in all metabolic pathways related to fibromyalgia biomarkers. Methods: Based on this evidence, we extend our investigation into dietary interventions for fibromyalgia by evaluating the impact of transitioning from a VLCKD to a low-glycemic insulinemic (LOGI) diet over an additional 45-day period. Therefore, participants initially following a VLCKD were transitioned to the LOGI diet after 45 days to determine whether the improvements in FM symptoms and metabolic dysfunctions achieved through VLCKD could be sustained with LOGI. Results: Our findings suggested that while VLCKD serves as an effective initial intervention for correcting metabolic imbalances and alleviating FM symptoms, transitioning to a LOGI diet offers a practical and sustainable dietary strategy. This transition preserves clinical improvements and supports long-term adherence and quality of life, underscoring the importance of adaptable nutritional therapies in chronic disease management. Control patients who adhered only to the LOGI diet for 90 days showed only modest improvement in clinical and psychological conditions, but not elimination of fibromyalgia symptoms. Conclusions: In conclusion the LOGI diet is an excellent alternative to maintain the results obtained from the regime VLCKD.
The Mediating Role of Body Mass Index in the Association Between Dietary Index for Gut Microbiota and Biological Age: A Study Based on NHANES 2007–2018
Authors: An Shuli , Qin Jian , Gong Xinjie , Li Shuangshuang , Ding Haiyan , Zhao Xue , He Hongqi , Zhou Linwei , Deng Xinrui , Chu Xia
Published: December 2024

Objective: The dietary index for gut microbiota (DI-GM) is a newly proposed metric for assessing diet quality, and its relationship with biological age is unclear. We hypothesize that consuming foods conducive to a healthy gut microbiota environment may decelerate aging. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2007 to 2018. The DI-GM was calculated by averaging the intakes from two 24-h dietary recall interviews. The biological age indicators were assessed using the Klemera–Doubal Method (KDM), phenotypic age (PA), and homeostasis disorder (HD). Logistic regression, restricted cubic splines (RCS), and mediation analysis were employed to explore the association between DI-GM and KDM, PA, and HD. Results: The study included 20,671 participants. According to the logistic regression model, adjusting for all covariates, a negative association was observed between the DI-GM score and biomarkers of biological aging. Compared to participants in the lowest quartile for DI-GM scores, those in the highest quartile exhibited reduced odds ratio (OR) for all of the biological age indicators, namely biological age assessed via KDM (OR: 0.69, 95% CI: 0.60–0.79), PA (OR: 0.84, 95% CI: 0.73–0.97), and HD (OR: 0.86, 95% CI: 0.76–0.98). Additionally, RCS analysis revealed a nonlinear association between DI-GM and biological age. Mediation analysis showed that the body mass index (BMI) partly mediated the association between DI-GM and biological age. Conclusions: Therefore, we concluded that a higher DI-GM score is associated with a lower risk of accelerated aging, with BMI mediating this association. Future research should validate these findings through the use of longitudinal studies.
Silymarin-Enriched Extract from Milk Thistle Activates Thermogenesis in a Preclinical Model of High-Fat-Diet-Induced Obesity to Relieve Systemic Meta-Inflammation
Authors: Reguero Marina , Reglero Guillermo , Quintela José Carlos , Ramos-Ruiz Ricardo , Ramírez de Molina Ana , Gómez de Cedrón Marta
Published: December 2024

Background: Obesity and aging are associated with the progressive loss of brown adipose tissue (BAT), an increase in visceral white adipose tissue (vWAT), and a reduction in subcutaneous white adipose tissue (sWAT). The progressive expansion of visceral obesity promotes a low grade of systemic chronic inflammation (meta-inflammation), contributing to the onset of comorbidities such as type 2 diabetes mellitus (T2DM), metabolic syndrome, and even cancer. Thus, preserving the thermogenic activity of adipose tissue and improving the metabolic flexibility of sWAT could be an effective strategy to prevent the development of metabolic chronic diseases and promote healthy aging. Precision nutrition has emerged as a complementary approach to control the metabolic alterations associated with unhealthy obesity and aging. In a previous work, we described that a silymarin-enriched extract from milk thistle (Mthistle) increased markers of browning and thermogenesis in vitro in human differentiated adipocytes (SGBS). Objectives/Methods: Therefore, this study aims to evaluate the potential of Mthistle to activate thermogenesis in a preclinical model of high-fat diet (HFD)-induced obesity (DIO). Results: Our results demonstrate that Mthistle increases systemic energy expenditure (EE), preserves body temperature after cold exposure, improves insulin resistance, and reduces inflammatory markers in WAT. Conclusions: Based on these results, silymarin-enriched extract from Mthistle may be proposed as a nutraceutical for the management of metabolic chronic diseases and/or accelerated aging.
Study on the Regulatory Mechanism of Niacin Combined with B. animalis F1-7 in Alleviating Alcoholic Fatty Liver Disease by Up-Regulating GPR109A
Authors: Liang Xi , Shan Tianhu , Zheng Xiumei , Zhang Zhe , Fan Yanping , Zhang Huaqi , Zhang Lanwei , Liang Hui
Published: December 2024

Background: This study aimed to investigate the effects of niacin combined with B. animalis F1-7 on the improvement of alcoholic fatty liver disease (AFLD) in mice and its potential regulatory mechanism. Methods: A total of 75 8-week-old male C57BL/6N mice were acclimated for one week and randomly divided into five groups: control group, alcohol model group (AFLD), niacin intervention group (NA), B. animalis F1-7 intervention group (F1-7), and niacin combined with B. animalis F1-7 intervention group (NF). The experiment lasted for 8 weeks. Results: The results showed that all intervention groups could effectively reduce the serum lipid levels and inflammatory response of mice induced by alcohol to varying degrees. The immunofluorescence analysis showed that the GPR109A in the liver and intestine of the NF group was significantly enhanced compared with the other groups. Niacin combined with B. animalis F1-7 better restored the gut microbiota. Meanwhile, each intervention group could increase their levels of SCFAs. Among them, the combination group increased the levels of acetic acid and butyric acid more significantly than the other two groups. The Spearman’s correlation analysis of gut microbiota and SCFAs showed that Norank_f_Eubacterium_coprostanoligenes_group, Allobaculum, and Akkermansia were positively correlated with changes in SCFAs, while Coriobacteriaceae_UCG-002, Romboutsia, and Clostridium_sensu_stricro_1 were negatively correlated. Conclusions: Niacin combined with B. animalis F1-7 better regulated the gut microbial balance and increased the SCFAs in mice with alcoholic steatohepatitis. The mechanism was related to the activation of the target GPR109A, which regulates the key proteins involved in lipid synthesis and β-oxidation to improve lipid metabolic disorders.
Clinical Efficacy of Probiotics for Allergic Rhinitis: Results of an Exploratory Randomized Controlled Trial
Authors: Lungaro Lisa , Malfa Patrizia , Manza Francesca , Costanzini Anna , Valentini Guido , Squarzanti Diletta Francesca , Viciani Elisa , Velichevskaya Alena , Castagnetti Andrea , Barbalinardo Marianna , Gentili Denis , Cariani Alessio , Ghisellini Sara , Caputo Fabio , De Giorgio Roberto , Caio Giacomo
Published: December 2024

Background: Allergic Rhinitis (AR) is an atopic disease affecting the upper airways of predisposed subjects exposed to aeroallergens. This study evaluates the effects of a mix of specific probiotics (L. acidophilus PBS066, L. rhamnosus LRH020, B. breve BB077, and B. longum subsp. longum BLG240) on symptoms and fecal microbiota modulation in subjects with AR. Methods: Probiotic effects were evaluated at the beginning (T0), at four and eight weeks of treatment (T1 and T2, respectively), and after four weeks of follow-up from the end of treatment (T3) (n = 19) compared to the placebo group (n = 22). AR symptoms and quality of life were evaluated by the mini rhinitis quality of life questionnaire (MiniRQLQ) at each time point. Allergic immune response and fecal microbiota compositions were assessed at T0, T2, and T3. The study was registered on Clinical-Trial.gov (NCT05344352). Results: The probiotic group showed significant improvement in the MiniRQLQ score at T1, T2, and T3 vs. T0 (p < 0.01, p < 0.05, p < 0.01, respectively). At T2, the probiotic group showed an increase in Dorea, which can be negatively associated with allergic diseases, and Fusicatenibacter, an intestinal bacterial genus with anti-inflammatory properties (p-value FDR-corrected = 0.0074 and 0.013, respectively). Conversely, at T3 the placebo group showed an increase in Bacteroides and Ruminococcaceae unassigned, (p-value FDR-corrected = 0.033 and 0.023, respectively) which can be associated with allergies, while the probiotic group showed a significative increase in the Prevotella/Bacteroides ratio (p-value FDR-corrected = 0.023). Conclusions: This probiotic formulation improves symptoms and quality of life in subjects with AR, promoting a shift towards anti-inflammatory and anti-allergic bacterial species in the intestinal microbiota.
A Systematic Review of Zoonotic Enteric Parasites in Synanthropic Mammalian Species in Florida
Authors: Perera Jeffrey M. , Gurtler Claire , Barnes Amber N.
Published: December 2024

Florida is home to a vast number of wildlife species that come into close contact with residents and domestic animals. As mammals are competent hosts for many zoonotic diseases, it is important to understand what exposure risks are present for both people and animals. Using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, this review analyzed published literature spanning 1963 through 2023 documenting zoonotic enteric parasites in synanthropic wild mammals of Florida, excluding mice and rats. Between an initial search conducted in 2022 and updated search in 2024, 10,563 titles were reviewed. Using predetermined inclusion and exclusion criteria, 26 titles were included in the final analysis examining a range of acanthocephala, cestode, nematode, protozoa, and trematode parasite species. Of the results, most studies found at least one parasite in Florida raccoons (n = 14) with additional studies in opossums (n = 8), armadillos (n = 4), bobcats (n = 4), coyotes (n = 3), squirrels (n = 3), gray foxes (n = 1), red foxes (n = 1), an undeclared fox type (n = 1), and bats (n = 1). No studies were found documenting zoonotic enteric parasites in rabbits or moles. The transmission pathways for each parasite and the zoonotic exposure risks varied significantly. Coordinated One Health prevention and control efforts must be targeted for effectiveness.
Humidity Resistant Biodegradable Starch Foams Reinforced with Polyvinyl Butyral (PVB) and Chitosan
Authors: Kulkarni Apoorva , Emrich Jakob , Narayan Ramani
Published: December 2024

In this study, water-insoluble, moisture-resistant starch foams were prepared using an optimized one-step extrusion-foaming process in a ZSK-30 twin screw extruder. The extrusion parameters, including temperature, screw configuration, die diameter, water content, and feeding rates, were optimized to achieve foams with the lowest density and controlled expansion. A screw configuration made up of three kneading sections was found to be the most effective for better mixing and foaming. Polyvinyl butyral (PVB) acted as a plasticizer, resulting in foams with a density of 21 kg/m3 and an expansion ratio of 38.7, while chitosan served as a nucleating agent, reducing cell size and promoting a uniform cell size distribution. The addition of PVB and chitosan reduced the moisture sensitivity of the foams, rendering them hydrophobic and water-insoluble. The contact angle increased from 0° for control foams to 101.5° for foams containing 10% chitosan and 10% PVB. Confocal laser scanning microscopy (CLSM) confirmed the migration of chitosan to the foam surface, enhancing hydrophobicity. Aqueous biodegradation tests, conducted at 30 °C in accordance with ISO 14852 standards, demonstrated that despite enhanced moisture resistance, the foams remained readily biodegradable, achieving approximately 80% biodegradation within 80 days. These modified starch foams present a sustainable solution for packaging and insulation applications that demand long-term humidity resistance.
Novel Treatment of 3D-Printed Short-Carbon-Fiber-Reinforced Polyamide (3D-SCFRPA66) Using Homogeneous Low-Potential Electron Beam Irradiation (HLEBI) and Ductility Enhancement
Authors: Miura Eiichi , Uchida Helmut Takahiro , Okazaki Taisuke , Sagawa Kohei , Faudree Michael C. , Salvia Michelle , Kimura Hideki , Nishi Yoshitake
Published: December 2024

In short-carbon-fiber-reinforced polyamide 66 articles shaped by 3D printing (3D-SCFRPA66), the interfaces between printed layers are often susceptible to damage, and the composite is excessively brittle. Therefore, a novel treatment for 3D-printed short-carbon-fiber-reinforced polyamide (3D-SCFRPA66) using homogeneous low-potential electron beam irradiation (HLEBI) to enhance tensile properties was investigated. In 3D-SCFRPA66 samples, ductility was measured based on the following parameters: strain at tensile strength (corresponding to homogeneous deformation) (εts) and resistance energy to homogeneous deformation, a measure of toughness (Ehd), which were both substantially increased. An HLEBI dose of 43.2 kGy at an acceleration potential of 210 kV for the finished 3D-SCFRPA66 samples increased the εts and Ehd values from 0.031 and 1.20 MPa·m for the untreated samples to 0.270 and 6.05 MPa·m for the treated samples, increases of 771% and 504%, respectively. Higher HLEBI doses of 86, 129, or 215 kGy also increased the εts and Ehd values to lesser degrees. Electron spin resonance (ESR) data in the literature show that HLEBI creates dangling bonds in Nylon 6. Since PA66 and Nylon 6 are constructed of C, N, and O and have similar molecular structures, HLEBI apparently severs the (-C-N-) bonds in the backbone of PA66, which have the lowest bond-dissociation energy (BDE) of ~326 to 335 kJ mol−1. This shortens the PA66 chains for higher ductility. In addition, for Nylon 6, X-ray photoelectron spectroscopy (XPS) data in the literature show that HLEBI reduces the N peak while increasing the C peak, indicating the occurrence of shortening chains via dangling bond formation accompanied by increases in crosslinking with carbon bonds. However, caution is advised, since HLEBI was found to decrease the tensile strength (σts) and initial elasticity ([dσ/dε]i) of 3D-SCFRPA66. This tradeoff can possibly allow the HLEBI dose to be adjusted for the desired ductility and strength while minimizing energy consumption.
Spatially Explicit Assessments of Heat-Related Health Risks: A Literature Review
Authors: Yao Yu , Lu Linlin , Guo Jiaqi , Zhang Shuangcheng , Cheng Jie , Tariq Aqil , Liang Dong , Hu Yonghong , Li Qingting
Published: December 2024

Extreme heat events, or heatwaves, exert significant impacts on human society, ecosystems, and the economy. The continuous development of remote sensing technology has facilitated the acquisition of high-quality data for assessing health risks associated with these extreme heat events. This study systematically reviews the evaluation factors and assessment framework for a spatially explicit assessment of heat-related health risks. The contribution of geospatial big data, with a particular focus on satellite observations, to these assessments was investigated. The Moderate Resolution Imaging Spectroradiometer (MODIS) and Landsat surface temperature (LST) are identified as the two most widely utilized data sources for mapping heat hazards. The incorporation of multi-sensor observations, along with the implementation of spatiotemporal fusion and downscaling techniques, enhances both the spatial resolution and temporal frequency of heat hazard characterization. It is essential to consider issues of justice and equality in heat-resilient planning and mitigation practices. Integrating heatwave risk assessment results with analyses of urban morphology, land use functions and infrastructure can provide critical information for government agencies to strategically plan urban layout, functions, and public service facilities while optimizing and enhancing urban green infrastructures.
The Status of Glaciers in the Western United States Based on Sentinel-2A Images
Authors: Abubakari Bernard , Ambinakudige Shrinidhi
Published: December 2024

In this study, we utilized Random Forest machine learning classification to assess the current state of glaciers in the western United States using Sentinel-2A satellite imagery. By analyzing Sentinel-2A imagery from September 2020 and comparing it to the RGI inventory, the study determined the current conditions of the glaciers. Our findings unveiled a significant reduction in both glacier area and volume in the western United States since the mid-20th century. Currently, the region hosts 2878 glaciers and perennial snowfield spanning eight states, covering a total area of 428.32 ± 7.8 km2 with a corresponding volume of 9.00 ± 0.9 km3. During the study period, a loss of 244.31 km2 in glacier area was observed, representing a 36.32% decrease when contrasted with the RGI boundaries. The volume lost during this period amounted to 4.96 km3, roughly equivalent to 4.7 gigatons of water. Among the states, Washington experienced the most significant glacier area reduction, with a loss of 133.16 km2. Notably, glaciers in the North Cascade Range of Washington, such as those in Mt. Baker and Mt. Shuksan, now cover, on average, only 85% of their original glacier boundaries with ice and snow at the conclusion of the 2020 hydrological year. Major glaciers, including the White River Glacier, West Nooksack Glacier, and White Chuck Glacier, have lost more than 50 percent of their original area.
Optimizing the Vegetation Health Index for Agricultural Drought Monitoring: Evaluation and Application in the Yellow River Basin
Authors: Hang Qinghou , Guo Hao , Meng Xiangchen , Wang Wei , Cao Ying , Liu Rui , De Maeyer Philippe , Wang Yunqian
Published: December 2024

The ecological environment of the Yellow River Basin in China is characterized by drought, which has been exacerbated by global warming. It is critical to keep accurate track of the region’s agricultural drought conditions. To enhance the vegetation health index (VHI), the optimal time scale for the standardized precipitation evapotranspiration index (SPEI) was determined by using the maximum correlation coefficient method, and the calculation method for VHI was optimized. The contributions of the vegetation condition index (VCI) and the temperature condition index (TCI) to the VHI were scientifically optimized, leading to the development of the optimal VHI (VHIopt). Soil moisture anomaly (SMA) and the SPEI were employed for assessing the performance of VHIopt. Furthermore, the temporal and spatial evolution of agricultural drought in the Yellow River Basin (YRB) was analyzed using VHIopt. The results indicate the following: (1) In the YRB, the optimal contribution of the VCI to the VHI is lower than that of the TCI. (2) The drought monitoring accuracy of VHIopt in forests, grasslands, croplands, and other vegetation types exceeds that of the original VHI (VHIori). Additionally, it demonstrates a high level of consistency with the SMA and the SPEI03 regarding spatial and temporal characteristics. (3) Agricultural drought in the YRB is gradually diminishing; however, significant regional differences remain. Generally, the findings of this study highlight that VHIopt is better suited to the specific climate and vegetation conditions of the Yellow River Basin, enhancing its effectiveness for agricultural drought monitoring in this region.
Review of Research Progress on Passive Direction-of-Arrival Tracking Technology for Underwater Targets
Authors: Hou Xianghao , Chen Yuxuan , Zhang Boxuan , Yang Yixin
Published: December 2024

Utilization of ocean resources and defense of national security heavily rely on underwater target tracking technology, which consequently holds significant strategic importance. The passive tracking technology for underwater target bearings, known for its extensive detection range, capability for long-term observation, and robust real-time capabilities, has emerged as a new focal point of research. This paper reviews the essential concepts, research developments, applications, and limitations of key technologies for passive underwater target bearing tracking, concentrating on three main areas: underwater target bearing estimation technology, target tracking technology, and comprehensive underwater target bearing tracking technology. Specifically, it discusses highly robust methods for tracking single or multiple underwater targets. Ultimately, this paper highlights the primary challenges currently facing research in this field and provides a perspective on future developments.