bluuebunny/crossref_metadata_2025 huggingface dataset:
Czech Republic television: genre and thematic features of TV news in 1989-2021
Authors: Lapuk Ekaterina V.
Published: July 2023

The author applies the content analysis to study 1608 video news of the Czech TV in 1989, 2005 and 2021. The studies of two categories “Genre” and “Thematic” were conducted. The hypotheses about the increase of negative information in TV news and the rise of entertainment content is tested. Much attention is given to seeking changes in the genres of TV news, which occur as a result of media convergence and the expansion of user-generated content. The greatest genre diversity was found in the modern period (2021), the lowest genre diversity was noted in 1989, when seven out of ten media texts were prepared in the “short note” genre. User-generated content brought only minor changes to the TV news genres. Over time, the role of PR-texts in TV news increases: the number of announcements increases more than tenfold between 1989 and 2021. Previous research indicate that mass media have a tendency to focus on violent and negative content. In the context of the TV news topics, it is demonstrated that nowadays there is an increase to some extent in news on crime and incidents and a slight decrease of the political agenda compared to 1989. Besides, it is reported that the number of sports TV news has significantly decreased, that confirms the trend of differentiation of the audience by TV programs focused on a single subject and specialty (or cable) channels.
AUTOMATIZACIÓN DE UN CULTIVO HIDROPÓNICO
Authors: Mateus Contreras David , Montenegro Gutiérrez Cristian Camilo , Romero Moreno Lina Maria , Méndez Pallares Baldomero
Published: July 2023

La hidroponía es una técnica de cultivo que debe desarrollarse como una medida para evitar el desgaste del suelo agrícola, por otro lado, dicha técnica permite que familias colombianas puedan cultivar algunas de las hortalizas que se consumen a diario. Por eso es fundamental diseñar un prototipo desde el campo de estudio de la automatización en mecatrónica de un  cultivo hidropónico inteligente, capaz de auto sustentarse. El proceso de investigación y el desarrollo del proyecto se puede observar en el siguiente artículo.
MENINGKATKAN EFEKTIVITAS PENDIDIKAN NONFORMAL DALAM PENGEMBANGAN KUALITAS SUMBER DAYA MANUSIA
Authors: SUSANTI SANI
Published: July 2023

ABSTRAK Keberadaan pendidikan non formal sangat penting dalam meningkatkan kualitas sumber daya manusia, hal ini tidak terlepas dari tujuan pendidikan non formal itu sendiri yaitu untuk melayani warga belajar supaya dapat tumbuh  dan berkembang sedini mungkin dan sepanjang hayatnya guna meningkatkan martabat dan mutu hidupnya; membina warga belajar agar memiliki pengetahuan, keterampilan, dan sikap mental yang diperlukan untuk mengembangkan diri, bekerja mencari nafkah atau melanjutkan ke tingkat dan/atau jenjang pendidikan yang lebih tinggi dan; memenuhi kebutuhan belajar masyarakat yang tidak dapat dipenuhi dalam jalur pendidikan sekolah. Sehingga diharapkan program pendidikan non formal dapat mencakup berbagai aspek kehidupan yakni pendidikan bermasyarakat, pendidikan ekonomi, dimana masyarakat mampu memenuhi kebutuhan hidupnya demi mencapai kesejahteraan hidup melalui pendidikan kecakapan hidup, pendidikan lingkungan, pendidikan budaya dan lain-lain. Cara yang dapat kita lakukan untuk meningkatkan efektivitas pendidikan non formal dalam pengembangan kualitas sumber daya manusia dapat dilakukan oleh penyelenggara pendidikan non formal maupun komunitas pendidikan non formal yaitu: pertama, perlu menata konsep yang tepat tentang program-program pendidikan non formal; kedua, perlu merencanakan program pendidikan non formal berbasis kebutuhan nyata arga belajar; ketiga, penyelenggaraan dan pengelolaan pendidikan non formal secara tekun dan berkelanjutan dengan prinsip-prinsip manajemen yang lebih jelas. Disamping itu kita juga harus meningkatkan kualitas pendidik dan tenaga kependidikan pendidikan non formal agar mereka dapat melaksanakan tugasnya secara profesional Sehingga kesannya pelaksanaan program pendidikan non formal bukan lagi bersifat sebagai sebuah proyek. Kata kunci: Efektifitas, Pendidikan Non Formal, Pengembangan, Kualitas, Sumber Daya Manusia.
PUPUK ORGANIK CAIR DAN PUPUK ORGANIK PADAT BAGI BUDIDAYA PISANG BARANGAN
Authors: Zaini Halim
Published: July 2023

Pupuk organik cair dan pupuk organik padat melalui proses fermentasi dimaksudkan untuk melaksanakan usaha pertanian secara organik serta melakukan perubahan pola manajemen pertanianke  arah pola pertanian yang efektif dan efisien. Hasil analisa kandungan kimia pupuk organik cair menunjukkan kadar mineral yang besar terutama kadar kalsium 283,2 ppm dan besi 132,54 ppm, sedangkan analisa kandungan kimia pupuk organik padat menunjukkan kadar C 9,93% dan N 0,61% dengan perbandingan berada antara 15 – 25. Berdasarkan aspek ekonomi dan penggunaan pupuk organik cair terhadap tanaman pisang barangan dan tanaman lainnya seperti tanaman sayur-sayuran menunjukkan hasil yang signifikat dimana pertumbuhan dan perkembangannya menunjukkan peningkatan dengan waktu pengembalian investasi tiga bulan masa panen dan dapat memberikan keuntungan dalam jangka waktu setelah tiga bulan panen dengan tingkat keuntungan rata-rata perbulan sebesar Rp 800.000,- perbulan. Kata Kunci : Pembuatan Pupuk, Pupuk Organik Cair, Pupuk Organik Padat, Usaha Pertanian
The main problems of the protection of displaced persons in the conditions of the Russian-Ukrainian war
Authors: Zhuravlyova G.S.
Published: July 2023

The development of the dynamics of the Russian Ukrainian conflict into a full-scale war led to the fact that a significant part of the residents of Ukraine left its borders, which also caused the need for their protection abroad. At the same time, questions arose regarding their protection as refugees or the use of other options for the protection of displaced persons as a result of the military conflict. As a result, there was an intensive migration of Ukrainians within Ukraine and abroad. The article distinguishes between the peculiarities of legal protection of internally displaced persons (IDP`s) and displaced persons abroad who use various forms of legal protection as a result of displacement from the war zone or occupied territories.The article discloses certain problems of the establishment of a mechanism for the protection of displaced persons in the conditions of the Russian Ukrainian war and the restoration of their violated rights. Differentiation of the legal protection of IDP`s and the protection of forcibly displaced persons from Ukraine abroad was carried out.The author came to the conclusion that mass displacement occurred as a result of the Russian Ukrainian war and the problem of protecting the rights of individuals as a result of this war has a dual nature. It is caused by the problems of the protection of IDP`s, the burden of which falls on Ukraine, and in the case of departure from the borders of Ukraine, on the relevant countries where the affected residents of Ukraine seek asylum within the framework of various procedures from recognition as a refugee to obtaining subsidiary protection. The structure of Ukrainian migration to the countries of Europe and North America is different from migration from the countries of the Middle East or Africa. Ukrainians prefer subsidiary protection as opposed to being recognized as a refugee, as this status allows them to preserve freedom of movement and free choice of occupation. Instead, after the end of the war, Ukraine will have to take measures to return Ukrainians home due to the critical demographic situation and the need to rebuild the country after the destruction caused by the war.
Dynamic Horizontal Voting Ensemble Deep Learning Approach to Combined Classification for Human Age, Gender and Ethnicity Soft Biometric Using Fingerprint Pattern
Authors: Olufunso Olorunsola Stephen , Evwiekpaefe Abraham E. , Irhebhude Martins E.
Published: July 2023

There is paucity of information regarding the probability that fingerprints may reveal combined soft biometric trait of human age, gender, and ethnicity. This challenge is due to lack of data. This has however, prompted academics to conduct their demographic classification-related work using the limited fingerprint dataset that is now available. However, complete fingerprint datasets collected under conventional and real-world conditions are not easily available for research reasons. This research aims to design a multi-task Deep Learning model for classifying the combined traits of ethnicity, gender, and age group estimation using fingerprint pattern. The fingerprint database was collected using a live scan method in real-world conditions, with subjects from three most numerous racial groups of Nigeria which are Yoruba, Igbo and Hausa, with consideration of the subject gender and age groups. The proposed method for the fingerprint image classification and training is the novel Dynamic Horizontal Voting Ensemble (DHVE) with Hybrid of Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) being utilized as the base (weak) learner. The dynamic selection method was utilized to determine classifiers in the normal horizontal voting ensemble, hence enhancing the ensemble technique's average accuracy. Standard performance classification metric inclusive of Accuracy, hold in thoughts, Precision, and F1 rating had been implemented to evaluate the model's performance. The result shows 76% accuracy in predicting person’s combined age group, ethnicity and gender. We also compared its performance against other approaches. It outperforms other cutting-edge algorithm like the CNN model in terms of performance metrics.
Fractura-luxación transescafoperilunar. Serie de casos
Authors: Alegría-Velasco Gabriel Fernando , Ramírez-Navarrete María Fernanda
Published: July 2023

Introducción. La articulación del carpo es, biomecánicamente, una de las más complejas; esta se conforma por varias estructuras osteoligamentarias cuya alteración puede generar inestabilidad carpi- ana ligamentaria pura o en asociación con lesión ósea, pudiéndose presentar fractura-luxación trans- escafoperilunada (FLTEPL), una lesión potencialmente devastadora. Un diagnóstico temprano y un tratamiento adecuado de este tipo de lesión son determinantes para un mejor pronóstico.

Objetivo. Revisar la literatura disponible sobre la FLTEPL traumática y presentar una serie de casos y la experiencia de los autores en su manejo.Materiales y métodos. Se evaluaron, de forma retrospectiva, seis pacientes que entre 2019 y 2022 sufrieron diferentes tipos de FLTEPL y tuvieron seguimiento a 24 meses. Se analizaron sus historias clínicas con especial énfasis en los protocolos quirúrgicos.

Resultados. Todos los participantes eran de género masculino con un rango de edad de 22 a 28 años y sufrieron la FLTEPL en accidentes en motocicleta; 5 lesiones fueron agudas y una, crónica. Los pro- medios de los rangos de movilidad a los 12 meses de seguimiento fueron los siguientes: pronación: 65° (rango de 60° a 70°), supinación: 60° (rango de 55° a 70°), exión de la muñeca: 58° (rango de 52 a 75°) y extensión de la muñeca: 56° (rango de 45° a 70°). En cuanto a los promedios obtenidos en las escalas funcionales a los 12 meses, estos fueron de 16.75 (rango de 7.5 a 27.5) en la DASH, de 18.42 (rango de 15 a 22) en la PRWE y de 2 en la EVA (dolor leve).

Conclusión. Las FLTEPL son lesiones raras y potencialmente devastadoras que requieren de alta sospecha diagnóstica para ser identi cadas y deben ser tratadas de forma temprana para lograr una óptima reducción ósea y reparación ligamentaria.
Development of non-financial reporting system as a business efficiency improving tool
Authors: Korzovatykh Zh. M.
Published: July 2023

The problem of increasing informativeness about all the components of the activities of economic entities is the basis for emergence of non-financial reporting system. It discloses non-financial information about the environmental status of an organization, its social responsibility, and sustainable development for the continuity of activities and careful attitude to nature. The activities of economic actors affect all spheres of social life and the environment as well, so the issue of non-financial reporting is relevant. The article studies state regulation of the system and identifies the need for area management and control. In order to effectively assess the contribution of an economic entity to the economy and the environment of a country, uniform standards for the composition and content of information disclosed in non-financial reporting and mandatory reflection parameters depending on the industry affiliation of companies, strategic orientation, and focus on the future are necessary to be used. Content-analysis of scientific publications on the system and general scientific methods of knowledge (systematic approach, logical generalization, and hypotheses) have been used as the methods of the research. The purpose of the study is to determine the main directions of harmonization of financial and non-financial reporting allowing to collect, evaluate, and analyze all the characteristics of an organization in the aggregate and increase the reliability of information about the economic entity as a whole.
Interaction of electronic declaration centers and customs posts of actual control in the conditions of legalization of parallel import
Authors: Sofiyannikova I. Yu.
Published: July 2023

This article studies the problems of the process of interaction of structural divisions of customs authorities on the example of electronic declaration centers and actual control posts in the conditions of legalization of parallel imports. The fact of such interaction directly affects the speed and quality of the provision of a key service of the customs authorities such as the release of goods. The main purpose of the article is to search for effective methods of customs control when transporting goods containing intellectual property objects. The relevance of the article is determined by the need to improve the customs operations performed in the context of the introduction of Western countries’ sanctions towards the Russian Federation. Practical examples of interaction between structural divisions of customs authorities are made. The main objective of this article is to propose possible ways to reduce time costs when deciding on the release of such goods. Both theoretical (analysis of the current legislation) and empirical research methods (giving practical examples of improving the effectiveness of customs control) are used. The result of the study is the development and proposal of sequential operations performed by customs authorities when controlling goods transported using parallel import technology.
Educational technologies in professional development of the land reclamation personnel in the context of digitalization
Authors: Pautova L. E.
Published: July 2023

The article analyzes the features of educational technologies for professional development of employees of reclamation organizations in the conditions of the educational and methodological center of additional professional education. The following general scientific research methods have been used: theoretical and practical analysis, development and systematization of information and analytical materials on professional training and development of employees of the Land Reclamation Department of the Ministry of Agriculture of the Russian Federation, logical and situational analysis, selective method in statistics, and result processing and generalization method. Relevant educational technologies for professional development of ameliorative industry workers and their gender-specific features, job categories, and stages of professional development that allow to determine significant changes in human resources of the industry have been identified for the first time. The features of implementation of promising areas of workers’ professional development in the reclamation industry of the agribusiness of the Ministry of Agriculture of the Russian Federation in the conditions of digital transformation have been revealed.
Possibilities of domestic railway engineering on the example of the Lastochka electric train
Authors: Plotnikova D. A.
Published: July 2023

The purpose of this article is to study the possibilities and assess the current state of the Russian railway engineering industry. The research paper analyzes the conditions conducive to the development of domestic railway engineering in the production of electric trains. The reasons for the demand for the Lastochka are described and the features of operation reflected, and the difficulties of localization of production listed. Due to domestic developments and various modifications, the electric train is recognized as universal and capable of a variety of operating conditions. The article focuses on the main competitive advantages of this train and the prospects for the development of the production of the Lastochkas in the Russian Federation within the framework of external sanctions pressure and a high level of uncertainty. The author reflects the advantages and disadvantages of replacing domestic electric trains as a part of import substitution with products from friendly or neutral countries. The study notes that in the near future the state will need to decide on a further policy of import substitution within the framework of risk assessment for the domestic economy.
SOCIO-PSYCHOLOGICAL ADAPTATION AND MOTIVATION OF VIETNAMESE STUDENTS TO STUDY IN RUSSIA
Authors: Нгуен Т.З. , Караванова Л.Ж.
Published: July 2023

Рассмотрены понятия «социально-психологическая адаптация» и «мотивация», изучены взгляды отечественных и зарубежных ученых. Приведены результаты исследования, в котором приняли участие 86 первокурсников (43 вьетнамских студента, 43 российских студента), обучающихся в Российском университете дружбы народов. На основании проведенного исследования сделаны выводы о социальнопсихологической адаптации вьетнамских студентов в российском вузе, о взаимосвязи социально-психологической адаптации и мотивации вьетнамских студентов в процессе обучения в российском вузе.

Considered and studied on the concepts of «social-psychological adaptation» and «motivation», the views of domestic and foreign scientists. The results of a study involve 86 first-year students (43 Vietnamese students, 43 Russian students) at the Peoples' Friendship University of Russia. On the basis of the study, conclusions were draw about the socio-psychological adaptation of Vietnamese students in the Russian university, the relationship between socio-psychological adaptation and motivation of Vietnamese students in the process of studying at the Russian university.
Metodología NIE y competencias emprendedoras en estudiantes de la Facultad de Comunicación Empresa y Negocios de la Universidad de Chiclayo – 2020
Authors: Castañeda Pérez Jorge Antonio , Elera Vilela Luis Alberto , Carpio Vásquez Weiky Nelly Juliana , Castro Castro Miguel Ángel
Published: July 2023

El objetivo de la investigación fue determinar la existencia y el posible incremento de las competencias emprendedoras en estudiantes mediante la aplicación de un Programa de Capacitación basado en la Metodología NIE (Nuevas Iniciativas Empresariales) de la Facultad de Comunicación Empresa y Negocios de la Universidad de Chiclayo - Perú. La investigación es de tipo descriptiva, transversal con diseño no-experimental. Se utilizó la técnica de la encuesta. Se selecciono la población total como muestra de la investigación, los datos se recopilaron, la recopilación se realizó mediante la aplicación del instrumento en persona alas unidades de investigación en un periodo de una semana. Para el tratamiento de datos se utilizó el software SPSS V.22 De acuerdo a los resultados del 100% de encuestados, el 54.84 % indica a veces, el 22.58% manifiesta nunca, 20.43% en resumen, la mayoría expresa que a veces o nuca desarrollan las competencias del grupo autoconfianza. Se concluyó que el estado actual de las competencias emprendedoras es deficiente evidenciándose la falta de mecanismos que permitan potenciar estas en los estudiantes, encontrándose un patrón en un estado de Nunca y casi nunca desarrollan estas competencias emprendedoras, evidenciando que hace falta mecanismos que permitan potenciar las competencias emprendedoras en los estudiantes de la Facultad de Comunicación empresa y Negocios.
Methodological Tools for the Implementation of Oil and Gas Projects on the arctic and Continental Shelf
Authors: Trofimov S. E.
Published: July 2023

The presented article considers the methodological tools for the practical implementation of offshore hydrocarbon projects from the perspective of the system-functional approach. The research analyzes the provisions of the concept of integrated field development in the context of the policy of import substitution in the Russian oil and gas industry. A number of directions of methodological tools application have been identified and distinguished: environmental, technological, transport, infrastructure (including construction and improvement of new supply routes). The article shows how the sustainable development of all segments of the oil and gas complex, the institutional platform on which they are based, and the introduction of the latest technologies —  all contribute to the integrated development of offshore hydrocarbon reserves.
Anais do XIV Seminário Interdisciplinar do Parfor/UFPI
Authors: Ferro Maria da Glória Duarte , Viana Bartira Araújo da Silva , Moura João Benvindo de
Published: July 2023

O objetivo geral do SIMPARFOR é fomentar a socialização de
experiências e refl exões sobre os contextos de formação e atuação dos
professores da educação básica, focalizando os desafi os e possibilidades
encontrados no desenvolvimento de práticas interdisciplinares.
O SIMPARFOR é uma iniciativa importante no processo de
institucionalização do Parfor e encalça a qualidade acadêmica e social
dos percursos formativos oferecidos aos docentes da educação pública
básica do estado do Piauí.
Doenças Tropicais Negligenciadas
Authors: Doce Kellvelyn Rodrigues , Ferreira Adriana Cardoso , Sousa Camila Rayssa Gomes de , Sousa Elcivane de Jesus , Feitosa Jackeline Amanda dos Santos , Aguiar Larissa Juliane Gomes de , Carvalho Lizandra Correa , Pimentel Nataniely Cristina Pinto , Santos Nathalia Marinho dos , Marques Rildo dos Santos , Lisbôa João David Batista , Reis Elaine Cristiny Evangelista dos
Published: July 2023

O material foi estruturado por discentes dos cursos de Bacharelado Interdisciplinar em Saúde (BIS), Farmácia e Ciências Biológicas, da Universidade Federal do Oeste do Pará (UFOPA), através da orientação de docentes da instituição. A ideia da construção do material, surgiu a partir das aulas da disciplina de Saúde Ambiental, na UFOPA, no ano de 2023. Entre os diversos temas abordados, Doenças Tropicais Negligenciadas (DTN) foi elencado, uma vez que na região Amazônica essas doenças predominantes acometem múltiplos indivíduos todos os anos e sua ocorrência pode ser reduzida. O material tem como objetivo informar e sensibilizar a população em geral acerca da dengue e da malária, quanto a sua transmissão, prevenção, tratamento e como proceder frente a sinais e sintomas relacionados as doenças.
LASERTERAPIA DE BAIXA INTENSIDADE NO TRATAMENTO DE FERIDAS: uma revisão integrativa de literatura
Authors: Bueno da Silva Eliézer , Iohan Fabíola , Cassão Gisele , Capellari Claudia
Published: July 2023

Objetivo: Identificar, com base nas publicações científicas, os resultados do uso da laserterapia de baixa intensidade no tratamento de feridas. Método:Trata-se de uma pesquisa descritiva tipo revisão integrativa da literatura (RIL). A pesquisa foi realizada por meio de busca eletrônica nas bases de dados: Banco de Dados em Enfermagem (BDENF), Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), US National Library of Medicine  (PUBMED) e Biblioteca Virtual em Saúde (BVS), considerando o recorte temporal de 2007 a 2022. Resultados e Conclusão: A maioria dos estudos avaliados, mostraram resultados estatisticamente significativos em variáveis como tempo de cicatrização e fechamento da ferida p=<0,002. Outro desfecho significativo foi para o alívio da dor p=<0,001, mostrando efeitos analgésicos. 
Descritores: Laserterapia AND Feridas e Lesões
THERMAL ASPECTS OF HEATING BOILER PLANTS OPERATION WITH HEAT-RECOVERY AND EXHAUST GAS RECIRCULATION
Authors: Fialko N. , Navrodska R. , Shevchuk S. , Stepanova A. , Serhiienko R.
Published: July 2023

The feature analysis of application for heating boiler plants of relatively small heating capacity, which are not equipped with air heaters, of the method of reducing the emission of nitrogen oxides due to decrease the temperature in the boiler furnace by recirculating exhaust gases into the blown air are presented. At the same time, heating gas-consuming boiler plants with traditional heat recovery systems of exhaust gases and implementation of this method with the selection of recycled gases after the boiler and heat-recovery exchanger are considered. The study results for a water-heating boiler with a heating capacity of 2 MW of the change regularities of the combustion temperature in the boiler furnace, the its exhaust gases temperature and water heated in the boiler as well as the boiler efficiency, depending on its relative heat load changed (from 30 to 100%) and with different parts of recirculated gases (from 10 to 20%) in the mixture with the blown air are presented. The studies were performed with and without them recirculation and heat recovery of flue gases. The research results show that the use of waste gas recirculation causes a noticeable decrease (by 150 – 250°C) in the combustion adiabatic temperature and a slight (by 0.5 – 4.7°C) decrease in the boiler waste gases temperature. Recirculation also leads to a decrease in boiler efficiency by 1.3 – 3.1% during the heating period, and the use of the considered heat recovery system of boiler waste gases with heating of return heat-network water by cooling them provides an increase in boiler efficiency by 2.5 – 8.1%. The resulting increase in boiler efficiency with a heat recovery and recirculation system is 0.1–4.8%.
Electrochemical removal of copper from synthetic wastewater using rotating cylinder electrode
Authors: Slaiman Qasim J. M. , Haweel Cecilia K. , Mohammed Suha A.
Published: July 2023

The performance of a batch undivided electrochemical reactor with a rotating cylinder electrode of woven-wire (60 mesh size), stainless steel 316, is examined for the removal of copper from synthetic solution of o.5 M sodium chloride containing 125 ppm at pH ≈ 3.5. The effect of total applied current, rotation speed on the figures of merit of the reactor is analyzed. For an applied current of 300 mA at 100 rpm, the copper concentration decreased from 125 to  mg l-1 after 60 min of electrolysis with a specific energy consumption of 1.75 kWh kg-1 and a normalized space velocity of 1.62 h-1. The change in concentration was higher when the total applied currents were increased because of the turbulence-promoting action of the hydrogen evolution. The results suggest that the applied current must represent a compromise between the increase in space time yield or normalized space velocity and the increase in the specific energy consumption.
Study the Efficiency of Drilling With Casing Operation in an Iraqi Oil Field
Authors: Alhaleem Ayad A.
Published: July 2023

Drilling with casing (DWC) can be considered as a modern drilling technique in which both of drilling and casing operations done in the same time by using the casing to transfer the hydraulic and mechanical power to the bit instead of traditional drilling string. To overcome oil well control, minimizing the total cost through enhancing drilling efficiency, drilling with casing was proposed as an enabling technology.

   Two surface sections (17 1/2 - and 12 1/4- inch) were drilled successfully in Rumaila oil field with  casing strings which reached 655m and 1524m measured depths respectively.

   By using DWC technique, the total drill/case phase time was reduced up to 20% comparing to conventional drilling in the same field .

   Drilling both sections with DWC system eliminating the number of trips and nonproductive time (NPT) related to wellbore instability.
Evaluation of Acid and Hydraulic Fracturing Treatment in Halfaya Oil Field-Sadi Formation
Authors: Al-Sudani Jalal Abdulwahid , Husain Khalid Munaf
Published: July 2023

Sadi formation is one of the main productive formations in some of Iraqi oil fields. This formation is characterized by its low permeability values leading to low production rates that could be obtained by the natural flow.

Thus, Sadi formation in Halfaya oil field has been selected to study the success of both of "Acid fracturing" and "Hydraulic fracturing" treatments to increase the production rate in this reservoir.

   In acid fracturing, four different scenarios have been selected to verify the effect of the injected fluid acid type, concentration and their effect on the damage severity along the entire reservoir.

   The reservoir damage severity has been taken as "Shallow–Medium– Severe" and (Medium–Severe-sallow) for better fluid invasion.

While, in hydraulic fracturing, a three cases have been selected using three different main fracturing fluid and three different proppant size and types, to verify their effects on fracturing efficiency, and dimensionless fracture conductivity.

   The results show that both treatments have successful results, but the hydraulic fracturing gives about (1.5) times greater than acid fracturing.

   However, the maximum dimensionless fracture conductivity reached by all the treatments was about (Fcd = 4) , with fracture efficiency reached to (82%).
Lumbar spine and hip motion angles are associated with movement direction of pain in patients with low back pain
Authors: Miyachi Ryo , Sano Ayaka , Tanaka Nana , Tamai Misaki , Miyazaki Junya
Published: July 2023

BACKGROUND:

The evaluation and treatment of patients with low back pain (LBP) often involve categorization based on movement direction. However, it is not certain whether the lumbar spine and hip motion angles are associated with movement direction in individuals with LBP.

OBJECTIVE:

The purpose of this study was to verify whether the motion angles of the lumbar spine and hip joint are associated with the movement direction in individuals with LBP.

METHODS:

Participants were recruited as volunteers at the authors’ institutions. In this cross-sectional observational study, participants were divided into two groups: those without LBP and those with LBP. To measure lumbar spine and hip motion angles in clinical movement tests (trunk forward bending and prone hip extension), those with LBP were divided into a flexion LBP group and an extension LBP group. Wearable sensors were used to measure lumbar spine and hip motion angles.

RESULTS:

Participants with LBP had a greater hip motion angle in the early stages of movement than that of those without LBP; this was associated with the movement direction in which pain appeared.

CONCLUSIONS:

In individuals with LBP, the motion angles of the lumbar spine and hip joint are associated with the movement direction. Therefore, this pain subgroup and associated movement direction should be considered when evaluating and treating individuals with LBP.
PENGUNGKAPAN TANGGUNG JAWAB PERUSAHAAN YANG TERDAFTAR DI BURSA EFEK INDONESIA PADA MASA PANDEMI COVID-19
Authors: Nurlaila Nurlaila , Nurwani Nurwani
Published: July 2023

COVID-19 has brought human activities to a halt which has an impact on business continuity, most companies have stopped their operational activities, making companies experience losses. This study aims to examine the effect of CSED and profitability on the company value of pharmaceutical companies listed on the Indonesia Stock Exchange for the period 2015-2019 and the period 2020 to determine the impact of COVID-19. The population of this study was 10 pharmaceutical companies, purposeful sampling technique was applied to select seven companies as samples. Data is obtained from reports of information or material facts about the impact of the COVID-19 pandemic on pharmaceutical companies from www.idx.co.id website. The results showed that CSED had a positive and significant effect on company value, while profitability had a positive but not significant effect on company value.
Sequência clínica de prótese parcial fixa metalocerâmica em área estética: Relato de caso
Authors: Lima Evelin Freire de , Santana Hellen Ketlyn Passos , Chagas Neto José Lacerda , Gouveia Thaysla Silva , Siqueira Santos Débora , Santos Stefhany Beatriz dos , Costa Max Dória
Published: July 2023

A perda dentária envolve fatores emocionais, sociais, econômicos e psicológicos, que gera grande impacto na saúde e na qualidade de vida do indivíduo. A substituição de dentes ausentes pode ser feita através de próteses parciais removíveis (PPR), implantes, próteses parciais fixas (PPF) convencionais totalmente cerâmicas ou metalocerâmicas, entre outras. Diante disso, esse trabalho tem como objetivo descrever a sequência clínica de reabilitação estética com prótese parcial fixa metalocerâmica, descrevendo um relato de caso clínico, em que uma paciente do gênero feminino apresentava ausência dentária extensa em região anterior da maxila. Onde o tratamento proposto foi capaz de devolver função, saúde e melhoria na qualidade de vida, nos quesitos sociais, psicológicos e, principalmente, no bem-estar e elevação da autoestima.
Implicações físicas em uma criança exposta a isotretinoína durante o período gestacional - Relato de caso
Authors: Nascimento Joab Aguiar do , Gomes Priscilla Paula Nascimento , Monteiro Quiria Ribeiro da Silva
Published: July 2023

A isotretinoína é um isômero sintético da tretinoína, composto derivado da vitamina A e substância ativa do medicamento Roacutan®, sendo o tratamento de primeira linha mais indicada para pacientes com acne severa e resistente, apesar de sua eficácia comprovada, a administração prolongada continua a ter controvérsias advindo seus potenciais efeitos adversos sendo estas alterações mucocutâneos e efeitos tóxicos sistêmicos e teratogênicos. Este trabalho trata-se de um relato de caso do tipo descritivo, qualitativo e exploratório, tendo por objetivo relatar as malformações fetais e implicações físicas em uma criança exposta a isotretinoína durante o período gestacional. Projeto aprovado no Comitê de Ética em Pesquisa sob o número do parecer: 5.816.399. As anormalidades associadas ao paciente incluem: dismorfismo facial, anormalidades no ouvido externo (microtia), anormalidades oculares (microftalmia), depressão da ponte nasal, mordida aberta anterior e atrasos no desenvolvimento neuropsicomotor, atraso motor generalizado, persistência de reflexos primitivos e tônicos, dificuldade em realizar as mudanças/trocas posturais e de decúbitos, e ausência de marcha, atraso no controle cervical, reações posturais, cognição e linguagem, comprometimento significativo da coordenação óculo-motriz. A isotretinoína é um fármaco com poderoso efeito teratogênico, a relação entre os riscos e benefícios do uso deste medicamento deve ser cuidadosamente avaliado, sendo uma contraindicação absoluta em gestantes pela possibilidade de alterações orgânicas e sistêmicas no feto, podendo apresentar incapacidades físicas, mentais, cognitivas e sociais.
Streptococcus suis surface-antigen recognition by antibodies and bacterial elimination is influenced by capsular polysaccharide structure
Authors: Dolbec Dominic , Lehoux Mélanie , Okura Masatoshi , Takamatsu Daisuke , Gottschalk Marcelo , Segura Mariela
Published: July 2023

Streptococcus suis is an encapsulated bacterium causing severe diseases in swine. Here, we compared the protective properties of the capsular polysaccharide (CPS) of different S. suis serotypes by using serotype-switched mutants in a mouse model of infection. CPS structure influenced bacterial survival in mice, antibody binding, and antibody-mediated bacterial killing. The CPS of serotypes 3, 4 and 14 allowed more antibody binding and bacterial elimination than the CPS of serotypes 2, 7 and 9. Results suggest that the different CPS structures of S. suis provide varying levels of protection by influencing antigen availability and elimination by the host immune system.
“As soon as I start trusting human beings, they disappoint me, and now I am going to get on an app that someone could hack. I really do not want to take that chance”: barriers and facilitators to digital peer support implementation into community mental health centers
Authors: Fortuna Karen L. , Divatia Shreya , Neupane Sudeep , Geiger Pamela , Bohm Andrew
Published: July 2023

Background

Certified peer support specialists often use technologies such as smartphone applications to deliver digital peer support in community mental health centers. Certified peer support specialists are individuals with a mental health diagnosis, trained and accredited by their state to provide mental health support services. Digital peer support has shown promising evidence of promoting recovery, hope, social support, and medical and psychiatric self-management among patients with a diagnosis of a serious mental illness. Interest in digital peer support as part of the patient experience has grown. Understanding barriers and facilitators to the implementation process of digital peer support into community mental health centers is a critical next step to facilitate uptake.

Methods

Semi-structured qualitative interviews were conducted with 27 patient participants (N = 17 persons with serious mental illness; N = 10 certified peer support specialists) from an urban community mental health center. Participants responded to open-ended questions on the barriers and facilitators of engaging with digital peer support technologies within community mental health centers. The interview guide and the responses were categorized according to the Consolidated Framework for Implementation Science Research (CFIR) constructs.

Results

Nine barriers and two facilitators were identified for the implementation of digital peer support in community mental health centers. The overarching domains for the identified barriers included (1) intervention characteristics (i.e., adaptability, complexity, and cost), (2) inner settings (i.e., implementation climate, readiness for implementation, and access to knowledge and information), and (3) characteristics of individuals (i.e., knowledge and beliefs about the intervention and other personal attributes). The two facilitators identified included (1) intervention characteristics (i.e., relative advantage) and (2) outer setting (i.e., patient needs and resources).

Conclusions

The identified barriers and facilitators represent a starting point for developing or modifying digital peer support technology requirements to ease implementation in community mental health centers. Building technology requirements and implementation processes based on these findings may facilitate uptake of digital peer support technologies by people with serious mental illness and certified peer support specialists in community mental health centers.
Mendelian randomization study of thyroid function and anti-Müllerian hormone levels
Authors: Liang Zhu , Xu Zijin , Liu Jianqiao
Published: July 2023

Objective

Although previous studies have reported an association between thyroid function and anti-Müllerian hormone (AMH) levels, which is considered a reliable marker of ovarian reserve, the causal relationship between them remains uncertain. This study aims to investigate whether thyrotropin (TSH), free thyroxine (fT4), hypo- and hyperthyroidism are causally linked to AMH levels.

Methods

We obtained summary statistics from three sources: the ThyroidOmics Consortium (N = 54,288), HUNT + MGI + ThyroidOmics meta-analysis (N = 119,715), and the most recent AMH genome-wide association meta-analysis (N = 7,049). Two-sample MR analyses were conducted using instrumental variables representing TSH and fT4 levels within the normal range. Additionally, we conducted secondary analyses to explore the effects of hypo- and hyperthyroidism. Subgroup analyses for TSH were also performed.

Results

MR analyses did not show any causality relationship between thyroid function and AMH levels, using normal range TSH, normal range fT4, subclinical hypothyroidism, subclinical hyperthyroidism and overt hypothyroidism as exposure, respectively. In addition, neither full range TSH nor TSH with individuals <50 years old was causally associated with AMH levels. MR sensitivity analyses guaranteed the robustness of all MR results, except for the association between fT4 and AMH in the no-DIO1+DIO2 group.

Conclusion

Our findings suggest that there was no causal association between genetically predicted thyroid function and AMH levels in the European population.
Spatiotemporal evolution and driving factors of the coupling coordination between county land urbanization and grain production: the case of Jiangsu province, China
Authors: Chen Xi , Zhou Junting , Xing Lirong , Wang Haitao , Lu Jianzhen
Published: July 2023

How to ensure a coordinated development between land urbanization and grain production has been a key issue that needs to be urgently addressed to achieve sustainable development in China. Taking Jiangsu province as an example, this paper measures the coupling coordination degree (CCD) between county land urbanization and grain production from 2010 to 2020 based on the coupling coordination degree model (CCDM). In addition, the exploratory spatial data analysis method and the space Durbin model are combined to explore the spatial correlation and influencing factors of the CCD between land urbanization and grain production. The main conclusions are as follows: (1) From a temporal perspective, the CCD between county land urbanization and grain production in Jiangsu is dominated by basically coordinated, with an overall stable rising trend and a distribution pattern of Northern Jiangsu > Central Jiangsu > Southern Jiangsu. (2) From the perspective of spatial distribution, the CCD between the two is dominated by basically coordinated in the Southern, Central and Northern Jiangsu regions. The spatial clustering characteristics are significant, and the distribution of counties with basically coordinated shows concentrated and contiguous characteristics. (3) From the perspective of spatial correlation, the CCD between the two shows a low level of positive spatial autocorrelation. The state of agglomeration is significant in Northern Jiangsu, while spatial agglomeration is sporadic in Southern Jiangsu and insignificant in Central Jiangsu. (4) The factors affecting the CCD between county land urbanization and grain production in Jiangsu province are determined by many factors together. Based on a driver perspective, Per capita GDP and chemical fertilizer application intensity have a negative effect on it. Highway network density and mobile internet penetration rate have a positive effect on it. Population density, advanced industrial structure, per capita grain planting area and agro-industrial agglomeration are not significant. This study offers useful insights for promoting the coupled and coordinated development of county urbanization and grain production in China.
Lenvatinib improves anti-PD-1 therapeutic efficacy by promoting vascular normalization via the NRP-1-PDGFRβ complex in hepatocellular carcinoma
Authors: Yang Jieying , Guo Zhixing , Song Mengjia , Pan Qiuzhong , Zhao Jingjing , Huang Yue , Han Yulong , Ouyang Dijun , Yang Chaopin , Chen Hao , Di Muping , Tang Yan , Zhu Qian , Wang Qijing , Li Yongqiang , He Jia , Weng Desheng , Xiang Tong , Xia JianChuan
Published: July 2023

Introduction

The limited response to immune checkpoint blockades (ICBs) in patients with hepatocellular carcinoma (HCC) highlights the urgent need for broadening the scope of current immunotherapy approaches. Lenvatinib has been shown a potential synergistic effect with ICBs. This study investigated the optimal method for combining these two therapeutic agents and the underlying mechanisms.

Methods

The effect of lenvatinib at three different doses on promoting tissue perfusion and vascular normalization was evaluated in both immunodeficient and immunocompetent mouse models. The underlying mechanisms were investigated by analyzing the vascular morphology of endothelial cells and pericytes. The enhanced immune infiltration of optimal-dose lenvatinib and its synergistic effect of lenvatinib and anti-PD-1 antibody was further evaluated by flow cytometry and immunofluorescence imaging.

Results

There was an optimal dose that superiorly normalized tumor vasculature and increased immune cell infiltration in both immunodeficient and immunocompetent mouse models. An adequate concentration of lenvatinib strengthened the integrity of human umbilical vein endothelial cells by inducing the formation of the NRP-1-PDGFRβ complex and activating the Crkl-C3G-Rap1 signaling pathway in endothelial cells. Additionally, it promoted the interaction between endothelial cells and pericytes by inducing tyrosine-phosphorylation in pericytes. Furthermore, the combination of an optimal dose of lenvatinib and an anti-PD-1 antibody robustly suppressed tumor growth.

Conclusions

Our study proposes a mechanism that explains how the optimal dose of lenvatinib induces vascular normalization and confirms its enhanced synergistic effect with ICBs.
Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics
Authors: Wacker Marcel , Bauer Jens , Wessling Laura , Dubbelaar Marissa , Nelde Annika , Rammensee Hans-Georg , Walz Juliane S.
Published: July 2023

Introduction

Mass spectrometry-based immunopeptidomics is the only unbiased method to identify naturally presented HLA ligands, which is an indispensable prerequisite for characterizing novel tumor antigens for immunotherapeutic approaches. In recent years, improvements based on devices and methodology have been made to optimize sensitivity and throughput in immunopeptidomics. However, developments in ligand isolation, mass spectrometric analysis, and subsequent data processing can have a marked impact on the quality and quantity of immunopeptidomics data.

Methods

In this work, we compared the immunopeptidome composition in terms of peptide yields, spectra quality, hydrophobicity, retention time, and immunogenicity of two established immunoprecipitation methods (column-based and 96-well-based) using cell lines as well as primary solid and hematological tumor samples.

Results

Although, we identified comparable overall peptide yields, large proportions of method-exclusive peptides were detected with significantly higher hydrophobicity for the column-based method with potential implications for the identification of immunogenic tumor antigens. We showed that column preparation does not lose hydrophilic peptides in the hydrophilic washing step. In contrast, an additional 50% acetonitrile elution could partially regain lost hydrophobic peptides during 96-well preparation, suggesting a reduction of the bias towards the column-based method but not completely equalizing it.

Discussion

Together, this work showed how different immunoprecipitation methods and their adaptions can impact the peptide repertoire of immunopeptidomic analysis and therefore the identification of potential tumor-associated antigens.