bluuebunny/crossref_metadata_2025 huggingface dataset:
An examination of the social perceptions and vaping preferences of young electronic nicotine delivery system users
Authors: Davidson Myles , Al-Hamdani Mohammed
Published: March 2023

Background

Little research has been conducted on social aspects and preferences of electronic nicotine delivery system (ENDS) use among young ENDS users, and none have examined differences in these aspects and preferences by gender and tobacco use status.

Methods

A total of 558 young regular vapers (ages 16–24; vaped at least once a week for the last 3 months) from Nova Scotia were recruited to complete a demographic and vaping questionnaire. A 2 x 3 study design was used to compare participants on social aspects and vaping preferences based on gender (male or female) and tobacco use status (never, former, or current smoker). Chi-square tests were used to determine significant differences, and Bonferroni tests were used to assess over- and under-representation within significant variables.

Results

Current tobacco-using male vapers had a higher frequency of experiencing pressure to vape from friends and current employment as compared to females. Former and never tobacco-using male vapers had a higher frequency of parental awareness of their vaping behavior than females. Former tobacco-using female vapers had a higher frequency of being influenced to vape by others they know on social media than males. Both never and former tobacco-using females reported a higher frequency of exposure to vaping content on social media than males. Never tobacco-using female vapers preferred vape pen devices relative to males.

Conclusions

Important gender differences by tobacco use status exist and demonstrate differential patterns of social influence for ENDS use and their experiences within this demographic.
Association between advance care planning and depressive symptoms among community-dwelling people with dementia: An observational cross-sectional study during the COVID-19 pandemic in Japan
Authors: Nakanishi Miharu , Nakashima Taeko , Miyamoto Yuki , Sakai Mai , Yoshii Hatsumi , Yamasaki Syudo , Nishida Atsushi
Published: March 2023

Objectives

Advance care planning (ACP) is an increasing priority for people with dementia during the COVID-19 pandemic. This study evaluated the association between ACP initiation and depressive symptoms among home-dwelling people living with dementia.

Methods

An internet-based questionnaire survey was conducted with Japanese family caregivers of home-dwelling persons with dementia in June 2021. Family caregivers evaluated the level of depressive symptoms in persons with dementia using the Neuropsychiatric Inventory (NPI). Caregivers also rated the quality of life of persons with dementia using the EQ-5D-5L.

Results

A total of 379 family caregivers participated in the survey. Depressive symptoms were reported in 143 persons with dementia (37.7%). A total of 155 persons with dementia (40.9%) had initiated ACP, of which 88 (56.8%) had care professionals involved in ACP conversation. After adjusting for the characteristics of persons with dementia and caregivers, persons with professional involvement showed significantly more severe depressive symptoms compared to those who did not initiate ACP. There was no significant difference in the quality of life of persons with dementia according to ACP initiation.

Conclusions

Many home-dwelling persons with dementia experienced depressive symptoms during the COVID-19 pandemic, especially in cases where care professionals were involved in ACP conversations. Optimal and proactive ACP approaches need to be developed to prevent depressive symptoms in newly diagnosed persons.
Psychosocial services provided by licensed cardiac rehabilitation programs
Authors: Bush Montika , Evenson Kelly R. , Aylward Aileen , Cyr Julianne M. , Kucharska-Newton Anna
Published: March 2023

Background

Professional health organizations recommend that outpatient cardiac rehabilitation programs include activities to optimize the physical, mental, and social well-being of patients. The study objectives were to describe among cardiac rehabilitation programs (1) mental health assessments performed; (2) psychosocial services offered; and (3) leadership's perception of barriers to psychosocial services offerings.

Methods

A cross-sectional survey of North Carolina licensed outpatient cardiac rehabilitation programs on their 2018 services was conducted. Descriptive statistics were used to summarize survey responses. Thematic analysis of free text questions related to barriers to programmatic establishment or expansion of psychosocial services was performed by two team members until consensus was reached.

Results

Sixty-eight programs (89%) responded to the survey. Forty-eight programs (70%) indicated offering psychosocial services; however, a majority (73%) of programs reported not directly billing for those services. At program enrollment, mental health was assessed in 94% of programs of which 92% repeated the assessment at discharge. Depression was assessed with the 9-item Patient Health Questionnaire by a majority (75%) of programs. Psychosocial services included individual counseling (59%), counseling referrals (49%), and educational classes (29%). Directors reported lack of internal resources (92%) and patient beliefs (45%) as the top barriers to including or expanding psychosocial services at their facilities.

Conclusions

Cardiac rehabilitation programs routinely assess mental health but lack the resources to establish or expand psychosocial services. Interventions aimed at improving patient education and reducing stigma of mental health are important public health opportunities.
Learning to generate pointing gestures in situated embodied conversational agents
Authors: Deichler Anna , Wang Siyang , Alexanderson Simon , Beskow Jonas
Published: March 2023

One of the main goals of robotics and intelligent agent research is to enable them to communicate with humans in physically situated settings. Human communication consists of both verbal and non-verbal modes. Recent studies in enabling communication for intelligent agents have focused on verbal modes, i.e., language and speech. However, in a situated setting the non-verbal mode is crucial for an agent to adapt flexible communication strategies. In this work, we focus on learning to generate non-verbal communicative expressions in situated embodied interactive agents. Specifically, we show that an agent can learn pointing gestures in a physically simulated environment through a combination of imitation and reinforcement learning that achieves high motion naturalness and high referential accuracy. We compared our proposed system against several baselines in both subjective and objective evaluations. The subjective evaluation is done in a virtual reality setting where an embodied referential game is played between the user and the agent in a shared 3D space, a setup that fully assesses the communicative capabilities of the generated gestures. The evaluations show that our model achieves a higher level of referential accuracy and motion naturalness compared to a state-of-the-art supervised learning motion synthesis model, showing the promise of our proposed system that combines imitation and reinforcement learning for generating communicative gestures. Additionally, our system is robust in a physically-simulated environment thus has the potential of being applied to robots.
Measuring objective fatigability and autonomic dysfunction in clinical populations: How and why?
Authors: Millet Guillaume Y. , Bertrand Mathilde F. , Lapole Thomas , Féasson Léonard , Rozand Vianney , Hupin David
Published: March 2023

Fatigue is a major symptom in many diseases, often among the most common and severe ones and may last for an extremely long period. Chronic fatigue impacts quality of life, reduces the capacity to perform activities of daily living, and has socioeconomical consequences such as impairing return to work. Despite the high prevalence and deleterious consequences of fatigue, little is known about its etiology. Numerous causes have been proposed to explain chronic fatigue. They encompass psychosocial and behavioral aspects (e.g., sleep disorders) and biological (e.g., inflammation), hematological (e.g., anemia) as well as physiological origins. Among the potential causes of chronic fatigue is the role of altered acute fatigue resistance, i.e. an increased fatigability for a given exercise, that is related to physical deconditioning. For instance, we and others have recently evidenced that relationships between chronic fatigue and increased objective fatigability, defined as an abnormal deterioration of functional capacity (maximal force or power), provided objective fatigability is appropriately measured. Indeed, in most studies in the field of chronic diseases, objective fatigability is measured during single-joint, isometric exercises. While those studies are valuable from a fundamental science point of view, they do not allow to test the patients in ecological situations when the purpose is to search for a link with chronic fatigue. As a complementary measure to the evaluation of neuromuscular function (i.e., fatigability), studying the dysfunction of the autonomic nervous system (ANS) is also of great interest in the context of fatigue. The challenge of evaluating objective fatigability and ANS dysfunction appropriately (i.e.,. how?) will be discussed in the first part of the present article. New tools recently developed to measure objective fatigability and muscle function will be presented. In the second part of the paper, we will discuss the interest of measuring objective fatigability and ANS (i.e. why?). Despite the beneficial effects of physical activity in attenuating chronic fatigue have been demonstrated, a better evaluation of fatigue etiology will allow to personalize the training intervention. We believe this is key in order to account for the complex, multifactorial nature of chronic fatigue.
Impact of age on short-term outcomes after pancreaticoduodenectomy: A retrospective case-control study of 260 patients
Authors: Zhao Zhirong , Zhou Shibo , Tang Yaping , Zhou Lichen , Ji Hua , Tang Zheng , Dai Ruiwu
Published: March 2023

Background

Although the increase of perioperative complications in the elderly undergoing pancreaticoduodenectomy (PD) surgery has been recognized, the definition of the “old patient” of PD in the studies is different and there is no accepted cut-off value at present.

Methods

279 consecutive patients who have undergone PD in our center between January 2012 and May 2020 were analyzed. Demographic features, clinical-pathological data and short-term outcomes were collected. The patients were divided into two groups, and the cut-off value (62.5 years) is picked based on the highest Youden Index. Primary endpoints were perioperative morbidity and mortality, and complications were classified according to the Clavien-Dindo Score.

Results

A total of 260 patients with PD were included in this study. Postoperative pathology confirmed pancreatic tumors in 62 patients, bile duct tumor in 105, duodenal tumor in 90, and others in 3. Age (OR = 1.09, P < 0.01), and albumin (OR = 0.34, P < 0.05) were significantly correlated with postoperative Clavien-Dindo Score ≥3b. There were 173 (66.5%) patients in the younger group (<62.5 years) and 87 (33.5%) in the elderly group (≥62.5 years). Significant difference between two groups was demonstrated for Clavien-Dindo Score ≥3b (P < 0.01), postoperative pancreatic fistula (P < 0.05), and perioperative deceases (P < 0.05).

Conclusions

Age and albumin were significantly correlated with postoperative Clavien-Dindo Score ≥3b, and there was no significant difference in predicting the grade of Clavien-Dindo Score. The cut-off value of elderly patients with PD was 62.5 years old and there were useful in predicting Clavien-Dindo Score ≥3b, pancreatic fistula, and perioperative death.
Case Report: Solitary metastasis to the appendix after curative treatment of HCC
Authors: Zhang Zun-Yi , Wang Yu-Wei , Zhang Wei , Zhang Bi-Xiang
Published: March 2023

Background

Liver cancer is now the fourth most common cancer in China. The most important factor in decreasing the overall survival is recurrence. Nearly 40%–70% of patients would be detected with intrahepatic or extrahepatic recurrence in 5 years after R0 resection. The intestine is not a usual site for extrahepatic metastasis. Only one case of hepatocellular carcinoma (HCC) metastasis to the appendix has been reported so far. So, it poses a difficulty for us to develop treatment plan.

Case presentation

Here, we report a very rare case of a recurrent HCC patient. R0 resection was first performed on this 52-year-old men who was diagnosed with Barcelona Clinic Liver Cancer stage A HCC. Different from other cases, a solitary metastasis to the appendix was detected 5 years after the R0 resection. After discussing with the multidisciplinary team, we decided to perform surgical resection again. The final postoperative pathology confirmed HCC. Complete responses were detected in this patient after the combined treatment of transarterial chemoembolization, angiogenesis inhibitors, and immune checkpoint inhibitors.

Conclusion

Because solitary metastasis to the appendix in HCC is very rare, this case might be the first reported in HCC patients after R0 resection. This case report highlights the efficacy of the combination of surgery, local regional therapy, angiogenesis inhibitors, and immune treatment in HCC patients with solitary metastasis to the appendix.
Time and temperature stability of Tritrichomonas foetus in phosphate-buffered saline as evaluated by a reverse transcription real-time PCR assay and field analysis
Authors: Loy Duan S. , Spuri Gomes Renata , Dutta Enakshy , Brodersen Bruce W. , Loy John Dustin
Published: March 2023

Tritrichomonas foetus (TF) is a significant reproductive pathogen of cattle, and sample collection, handling, transport, and testing are significant hurdles to surveillance programs. Recent methods have been developed that allow for the direct detection of TF using a reverse transcription real-time PCR (direct RT-qPCR) approach. To evaluate these methods, a comparative analysis was conducted to assess the technical performance of this assay with a commercially available real-time PCR (qPCR) assay. In addition, the evaluation of two types of collection media (PBS and TF transport tube) was conducted that evaluated sample stability from 0 to 3 days when stored at 4°C or 25°C. Extended incubation times for PBS media were also evaluated (5, 7, and 14 days) at both refrigeration and frozen temperatures to evaluate the effect of extended transport time on samples. Limits of detection (LODs), dynamic range, and RNA stability were assessed using lab-cultured TF spiked into samples of normal bovine smegma collected in PBS or TF transport media, and performance was assessed on field samples collected in parallel. 100% agreement was found between direct RT-qPCR and qPCR at 10 parasites/extraction and a LOD of 1 parasite/extraction. Differences in detection were not observed in either collection media when incubated at either temperatures for up to 3 days of incubation. In addition, the extended incubation experiments indicate that samples containing 10 parasites/extraction can be detected at 4°C for 5 days with a mean Cq 26.34 (95% CI: 23.11–29.58) and detected at −20°C for 7 or 14 days, with a mean Cq 29.55 (95% CI: 27.73–31.37). A significant decrease in detectable RNA was observed in samples containing <10 parasites/extraction at −20°C for 14 days, which should be considered for long-term storage. In summary, direct RT-qPCR was found to be equivalent or superior to qPCR and PBS was not significantly different from TF transport media. The findings of the current study allows for more flexibility during sample collection and transport and ultimately enhancement of TF surveillance programs.
Pathological features of African horse sickness virus infection in IFNAR−/− mice
Authors: Jones Luke M. , Hawes Phillippa C. , Salguero Francisco J. , Castillo-Olivares Javier
Published: March 2023

African Horse Sickness (AHS) is a vector-borne viral disease of equids. The disease can be highly lethal with mortality rates of up to 90% in non-immune equine populations. The clinical presentation in the equine host varies, but the pathogenesis underlying this variation remains incompletely understood. Various small animal models of AHS have been developed over the years to overcome the financial, bio-safety and logistical constraints of studying the pathology of this disease in the target species. One of the most successful small animal models is based on the use of interferon-alpha gene knock-out (IFNAR−/−) mice. In order to increase our understanding of African Horse Sickness virus (AHSV) pathogenesis, we characterised the pathology lesions of AHSV infection in IFNAR−/− mice using a strain of AHSV serotype 4 (AHSV-4). We found AHSV-4 infection was correlated with lesions in various organs; necrosis in the spleen and lymphoid tissues, inflammatory infiltration in the liver and brain, and pneumonia. Significant viral antigen staining was only detected in the spleen and brain, however. Together these results confirm the value of the IFNAR−/− mouse model for the study of the immuno-biology of AHSV infections in this particular in vivo system, and its usefulness for evaluating protective efficacy of candidate vaccines in preclinical studies.
Estimates of on-farm antimicrobial usage in egg production in the United States, 2016–2021
Authors: Singer Randall S.
Published: March 2023

Very few data exist globally regarding the use of antimicrobials in the table egg industry. Antimicrobial use data from broiler chickens and turkeys cannot be used as a surrogate of layer chickens because of the fact that table eggs for human consumption are produced daily by laying hens. To avoid the possibility of antimicrobial residues in the eggs, there are very few antimicrobials approved for use in layers in the U.S. The objective of this study was to collect on-farm antimicrobial use data from the U.S. table egg industry and to have it be representative of the national layer flock. Participation was voluntary. Data were collected for the period 2016 through 2021 and are reported on a calendar year basis. Using production statistics from USDA:NASS as a denominator, the data supplied by participating companies accounted for 3,016,183,140 dozen eggs (~40% of national egg production) in 2016 and 3,556,743,270 dozen eggs (~45% of national egg production) in 2021. All of the replacement chicks placed on pullet farms during the study period were estimated to have received 0.2 mg/chick gentamicin at the hatchery. Most of the antimicrobial administration in U.S. egg production is via the feed. The ionophores monensin and salinomycin were used in the pullets, bacitracin was used in both pullets and layers (primarily for control of necrotic enteritis), and chlortetracycline was used primarily in layers for the treatment of E. coli-related disease. In the layers, between 0.10 and 0.19% of total hen-days were exposed to chlortetracycline. Only two water-soluble administrations were recorded during the entire study period, both involving lincomycin to pullet flocks for the treatment of necrotic enteritis. Overall, antimicrobial use in the U.S. layer industry was focused mainly on controlling necrotic enteritis in the pullets and treating E. coli-related disease in the laying hens.
3D printed plates based on generative design biomechanically outperform manual digital fitting and conventional systems printed in photopolymers in bridging mandibular bone defects of critical size in dogs
Authors: Baumgartner Doris , Schramel Johannes Peter , Kau Silvio , Unger Ewald , Oberoi Gunpreet , Peham Christian , Eberspächer-Schweda Matthias
Published: March 2023

Conventional plate osteosynthesis of critical-sized bone defects in canine mandibles can fail to restore former functionality and stability due to adaption limits. Three-dimensional (3D) printed patient-specific implants are becoming increasingly popular as these can be customized to avoid critical structures, achieve perfect alignment to individual bone contours, and may provide better stability. Using a 3D surface model for the mandible, four plate designs were created and evaluated for their properties to stabilize a defined 30 mm critical-size bone defect. Design-1 was manually designed, and further shape optimized using Autodesk®Fusion 360 (ADF360) and finite element analysis (FE) to generate Design-2. Design-4 was created with the generative design (GD) function from ADF360 using preplaced screw terminals and loading conditions as boundaries. A 12-hole reconstruction titanium locking plate (LP) (2.4/3.0 mm) was also tested, which was scanned, converted to a STL file and 3D printed (Design-3). Each design was 3D printed from a photopolymer resin (VPW) and a photopolymer resin in combination with a thermoplastic elastomer (VPWT) and loaded in cantilever bending using a customized servo-hydraulic mechanical testing system; n = 5 repetitions each. No material defects pre- or post-failure testing were found in the printed mandibles and screws. Plate fractures were most often observed in similar locations, depending on the design. Design-4 has 2.8–3.6 times ultimate strength compared to other plates, even though only 40% more volume was used. Maximum load capacities did not differ significantly from those of the other three designs. All plate types, except D3, were 35% stronger when made of VPW, compared to VPWT. VPWT D3 plates were only 6% stronger. Generative design is faster and easier to handle than optimizing manually designed plates using FE to create customized implants with maximum load-bearing capacity and minimum material requirements. Although guidelines for selecting appropriate outcomes and subsequent refinements to the optimized design are still needed, this may represent a straightforward approach to implementing additive manufacturing in individualized surgical care. The aim of this work is to analyze different design techniques, which can later be used for the development of implants made of biocompatible materials.
CircRNA: A new class of targets for gastric cancer drug resistance therapy
Authors: Zheng Ying , Li Zhe , Wang Yao , Chen Wanjiao , Lin Yifan , Guo Junming , Ye Guoliang
Published: March 2023

Gastric cancer (GC) is one of the most common malignancies worldwide. Patients with advanced GC need palliative care to ensure survival. This includes the use of chemotherapy agents, such as cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and pemetrexed, as well as targeted agents. However, the emergence of drug resistance evidence in poor patient outcomes and poor prognosis is a motivation to determine the specific mechanism of drug resistance. Interestingly, circular RNAs (circRNAs) play an important part in the carcinogenesis and progression of GC and are involved in GC drug resistance. This review systematically summarizes the functions and mechanisms of circRNAs underlying GC drug resistance, especially chemoresistance. It also emphasizes that circRNAs can serve as promising targets for improving drug resistance and therapeutic efficacy.
Performance Evaluation of a High-Torque Permanent Magnet Brake at Operating Temperature Based on Magneto-Thermal Coupling Method
Authors: Wu Yichao , Li Yong , Wang Guixian , Zhang Chaohui , Pang Jihong
Published: March 2023

As the key component of a servo motor, the torque and temperature rise of the brake at the operating temperature affect the production quality of injection molding machines and other equipment. To achieve application of the brake and evaluate its performance at a high operating temperature, a high-torque permanent magnet brake with an axial disc structure is proposed. The permanent magnet consists of six small magnets instead of the traditional monolithic ring magnet. The key parameters of the coil are designed, and the magneto-thermal coupling method is established. The magneto-thermal coupling method considers the effect of temperature on material properties and feeds the temperature back to the electromagnetic field to correct the resistance, permeability, remanence and other coefficients. It then updates the heat source of the temperature field. The temperature rise is calculated iteratively between the electromagnetic field and the temperature field. The simulation results of the one-way method and the magneto-thermal coupling method are obtained and compared with the experimental results. The evaluation errors of the magneto-thermal coupling method for temperature and braking torque are 1.9% and 4.7% respectively, which are lower than the errors of the one-way method.
Short-Term Biochar Impacts on Crop Performance and Soil Quality in Arid Sandy Loam Soil
Authors: Keller Lindsay , Idowu Omololu John , Ulery April , Omer Mohammed , Brewer Catherine E.
Published: March 2023

A two-year field study was conducted in sandy loam soil to evaluate the impacts of biochar on soil quality and the growth and yields of pinto bean (Phaseolus vulgaris) and sorghum–Sudan (Sorghum × drummondii). A wood-derived commercial biochar was applied at three rates to pinto bean (PB) and sorghum–Sudan (SS) plots. The biochar application rates applied annually for two years to PB plots were 0, 2.2, and 11.2 Mg ha−1, whereas the rates for SS plots were 0, 3.4, and 6.7 Mg ha−1. Crop growth and harvest parameters were evaluated. Assessed soil measurements included pH, electrical conductivity, available nutrients, soil organic matter (SOM), permanganate oxidizable carbon (POXC), soil aggregates, and volumetric soil moisture content. The results showed no significant differences in plant growth parameters and yields over the two growing seasons for both PB and SS. Compared to the control treatment, the biochar at 11.2 Mg ha−1 in PB plots improved soil moisture retention after irrigation by 19% in the first year and 25% in the second year. The SOM in the SS plot at 6.7 Mg ha−1 biochar rate was higher (1.02%) compared to the control plot (0.82%), whereas a similar increase was not observed in the PB plot. Although biochar rates did not affect most of the soil measurements, there were significant changes in soil properties over time, regardless of biochar treatments: POXC increased in the PB and SS plots; SOM increased in the SS plot; and electrical conductivity, sodium adsorption ratio, and most soil micronutrients decreased. This research was conducted over two years; the effects of biochar can persist for much longer, indicating the need for longer-term biochar field studies in arid agroecosystems.
Will Climate Change Affect the Disease Progression of Septoria Tritici Blotch in Northern Europe?
Authors: Prahl Ketel Christian , Klink Holger , Hasler Mario , Verreet Joseph-Alexander , Birr Tim
Published: March 2023

Septoria tritici blotch (STB), caused by the fungus Zymoseptoria tritici Desm., is the most important disease affecting wheat in Northern Europe. There is a strong correlation between STB and weather variables; therefore, research on climate change and epidemiology is essential. In a long-term survey across 25 years, we evaluated the epidemiological development of STB at a representative location under maritime climatic conditions. The surveys conducted between 1996 and 2021 showed an increase in disease severity of STB with respect to time. At the survey location, the plants were also evaluated for other diseases, but other foliar diseases were only observed with negligible severities. However, a continuous increase in the severity of STB was observed throughout the survey. During the survey period, there was no significant relationship between disease severity and single weather parameters (e.g., temperature and precipitation). However, seasonal changes in the progression of conducive STB conditions within the season were observed during the survey. Therefore, STB infections occurred at increased temperatures due to infections later during the growth season. In general, the distribution of conducive weather conditions, which supports an infection, determines the epidemiological behaviour of STB during the growing season. Due to these enhanced STB epidemics, a decline in wheat production has been observed, especially in agronomic practices of maritime climates. This is particularly the case if temperature and precipitation during the growing season are affected by climate change.
Developing Temperature-Resilient Plants: A Matter of Present and Future Concern for Sustainable Agriculture
Authors: Raza Ali , Wang Daojie , Zou Xiling , Prakash Channapatna S.
Published: March 2023

Plants are decisive for nurturing life on Earth, but climate change threatens global food security, poverty decrease, and sustainable agriculture [...]
Remediation of Cd and Cu Contaminated Agricultural Soils near Oilfields by Biochar Combined with Sodium Humate-Wood Vinegar
Authors: Wang Junqi , Gao Weichun , Zhu Junfeng , Yang Yuxiao , Niu Yuhua
Published: March 2023

Soil contaminations by heavy metals near oilfields have been widely reported and are causing great concern. Thus, it is highly desirable to develop cost-effective materials and methods to avoid heavy metal residues contaminating soil and food. An effective, environmentally friendly, and inexpensive remediation material for heavy metal-polluted soil was designed and prepared using biochar (BC) combined with humic acid (HA) resulting from sodium humate (NaHA) simply reacting with wood vinegar (BHW). After adding BHW, the chemical fractions of copper and cadmium in the soil undergo larger changes. Meanwhile, the availability of heavy metals decreases. The maximum adsorption capacity of copper and cadmium in the soil using the BHW is larger than that only using biochar. The adsorption kinetics ensures that the adsorption process of Cd2+ and Cu2+ ions on BHW is chemical adsorption, which is best fitted using the pseudo-second-order rate equation. The thermodynamics guarantees that the metal ions adsorb on the heterogeneous surface of BHW in multilayer, which is credited to the enhancement of oxygen-containing groups in the biochar combined with the humic acid. The remediation material BHW holds promise for the immobilization of heavy metal in the soils and could be recommended based on its economic feasibility, high efficacy, and environmental safety.
Identification of Wheat Germplasm Resistance to Late Sowing
Authors: Basheir Samia Mahgoub Omer , Hong Yi , Lv Chao , Xu Hongwei , Zhu Juan , Guo Baojian , Wang Feifei , Xu Rugen
Published: March 2023

To evaluate the performance of wheat plant height and spike-related traits under delayed sowing conditions, a screening trial was conducted for wheat germplasm that exhibits resistance to late sowing and early maturity. The differences and stability of plant height and spike-related traits under different sowing dates were analyzed using 327 wheat germplasm sources from a wide range of areas. The results showed that mean values of wheat plant height and spike-related traits generally decreased along with the delay in sowing dates. Broad-sense heritability of plant height (PH), internode length below spike (ILBS), spike length (SL), spikelet per spike (SPS), and spike number (SN) under multiple environments were all above 85%. Ten varieties, including Xiangmai 35, Pingyang 27, Huaimai 23, Huaimai 22, Emai 6, Zhenmai 12, Xiaoyan 81, Shannong 7859, Annong 1589, and Shuiyuan 86 indicated stable performance under different sowing dates, which harboring good resistance to late sowing. The results of this study laid a foundation for breeding high-yield wheat varieties that are resistant to late sowing.
Importance of Mid-Infrared Spectra Regions for the Prediction of Mastitis and Ketosis in Dairy Cows
Authors: Gruber Stefan , Rienesl Lisa , Köck Astrid , Egger-Danner Christa , Sölkner Johann
Published: March 2023

Mid-infrared (MIR) spectroscopy is routinely applied to determine major milk components, such as fat and protein. Moreover, it is used to predict fine milk composition and various traits pertinent to animal health. MIR spectra indicate an absorbance value of infrared light at 1060 specific wavenumbers from 926 to 5010 cm−1. According to research, certain parts of the spectrum do not contain sufficient information on traits of dairy cows. Hence, the objective of the present study was to identify specific regions of the MIR spectra of particular importance for the prediction of mastitis and ketosis, performing variable selection analysis. Partial least squares discriminant analysis (PLS-DA) along with three other statistical methods, support vector machine (SVM), least absolute shrinkage and selection operator (LASSO), and random forest (RF), were compared. Data originated from the Austrian milk recording and associated health monitoring system (GMON). Test-day data and corresponding MIR spectra were linked to respective clinical mastitis and ketosis diagnoses. Certain wavenumbers were identified as particularly relevant for the prediction models of clinical mastitis (23) and ketosis (61). Wavenumbers varied across four distinct statistical methods as well as concerning different traits. The results indicate that variable selection analysis could potentially be beneficial in the process of modeling.
Contamination of Zophobas morio Larvae Rearing Substrate with Listeria monocytogenes: A Preliminary Study
Authors: Fratini Filippo , Ciurli Luca , Forzan Mario , Kaboudari Ata , Copelotti Emma , Paci Gisella , Mancini Simone
Published: March 2023

The interest in edible insects is continuously increasing due to their environmental, nutritional, and productive features. The aim of this study was to evaluate the effects and survival of Listeria monocytogenes in Zophobas morio rearing, using two different bacterial loads (2 and 6 log CFU/g). We also considered the effect of washing, fasting, and cooking treatments on the larvae. During the experimental trial, no mortality was observed among the larvae. The L. monocytogenes loads decreased over time, and it was below the detection limit for crates inoculated with 2 log CFU/g, while the substrate inoculated with 6 log CFU/g reached loads of 4.26 (without larvae) and 2.83 log CFU/g (with larvae). Due to the absence of L. monocytogenes in the larvae on day seven, it was not possible to assess the fasting treatment or the washing and the cooking. However, when looking at the total microbial count, significant effects were revealed for all treatments. The unfasted larvae showed no effect of washing, while the total microbial counts decreased after washing in the fasted larvae. This proves that fasting is a good treatment in terms of hygiene assurance for the consumer.
The Antibacterial and Antifungal Capacity of Eight Commercially Available Types of Mouthwash against Oral Microorganisms: An In Vitro Study
Authors: Di Lodovico Silvia , Dotta Tatiane Cristina , Cellini Luigina , Iezzi Giovanna , D’Ercole Simonetta , Petrini Morena
Published: March 2023

This work aimed to evaluate and compare the antimicrobial actions and effects over time of eight types of mouthwash, based on the impact of chlorhexidine on the main microorganisms that are responsible for oral diseases: Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans. The mouthwashes’ antimicrobial action was determined in terms of their minimum inhibitory concentration (MIC), minimum bactericidal/fungicidal concentration (MBC/MFC), and time-kill curves at different contact times (10 s, 30 s, 60 s, 5 min, 15 min, 30 min, and 60 min), against selected oral microorganisms. All the mouthwashes showed a notable effect against C. albicans (MICs ranging from 0.02% to 0.09%), and higher MIC values were recorded with P. aeruginosa (1.56% to >50%). In general, the mouthwashes showed similar antimicrobial effects at reduced contact times (10, 30, and 60 s) against all the tested microorganisms, except with P. aeruginosa, for which the most significant effect was observed with a long time (15, 30, and 60 min). The results demonstrate significant differences in the antimicrobial actions of the tested mouthwashes, although all contained chlorhexidine and most of them also contained cetylpyridinium chloride. The relevant antimicrobial effects of all the tested mouthwashes, and those with the best higher antimicrobial action, were recorded by A—GUM® PAROEX®A and B—GUM® PAROEX®, considering their effects against the resistant microorganisms and their MIC values.
Antioxidant Supplementation on Male Fertility—A Systematic Review
Authors: Dimitriadis Fotios , Borgmann Hendrik , Struck Julian , Salem Johannes , Kuru Timur
Published: March 2023

Our aim was to review the current literature regarding the effect of antioxidant supplementation (AS) on male fertility parameters, as AS is commonly used to treat male infertility due to the availability and affordability of antioxidants in many parts of the world. Materials and methods: PubMed, Medline, and Cochrane electronic bibliographies were searched using the modified Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines to evaluate studies on the benefit of antioxidant therapy on infertile men. Results were analyzed regarding the following aspects: (a) ingredient and dose; (b) potential mechanism of action and rationale for use; and (c) effect on various reported outcomes. Results: Thus, 29 studies found a substantial positive effect of AS on outcomes of assisted reproductive therapy (ART), WHO semen parameters, and live-birth rate. Carnitines, Vitamin E and C, N-acetyl cysteine, coenzyme Q10, selenium, zinc, folic acid, and lycopene were beneficial ingredients. Nevertheless, some studies did not show a substantial change in one or more factors. Conclusion: AS seems to have a positive effect on male fertility. Environmental factors may play an increasing role in fertility. Further studies are needed to determine the optimal AS combination and the influence of environmental factors.
Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway
Authors: Hao Wenhui , Shan Wenjie , Wan Fang , Luo Jingyi , Niu Yaoyun , Zhou Jin , Zhang Yaou , Xu Naihan , Xie Weidong
Published: March 2023

Vascular aging is an important factor contributing to cardiovascular diseases, such as hypertension and atherosclerosis. Hyperlipidemia or fatty accumulation may play an important role in vascular aging and cardiovascular diseases. Canagliflozin (CAN), a sodium-glucose cotransporter inhibitor, can exert a cardiovascular protection effect that is likely independent of its hypoglycemic activities; however, the exact mechanisms remain undetermined. We hypothesized that CAN might have protective effects on blood vessels by regulating vascular aging induced by hyperlipidemia or fatty accumulation in blood vessel walls. In this study, which was undertaken on the basis of aging and inflammation, we investigated the protective effects and mechanisms of CAN in human umbilical vein endothelial cells induced by palmitic acid. We found that CAN could delay vascular aging, reduce the secretion of the senescence-associated secretory phenotype (SASP) and protect DNA from damage, as well as exerting an effect on the cell cycle of senescent cells. These actions likely occur through the attenuation of the excess reactive oxygen species (ROS) produced in vascular endothelial cells and/or down-regulation of the p38/JNK signaling pathway. In summary, our study revealed a new role for CAN as one of the sodium-dependent glucose transporter 2 inhibitors in delaying lipotoxicity-induced vascular aging by targeting the ROS/p38/JNK pathway, giving new medicinal value to CAN and providing novel therapeutic ideas for delaying vascular aging in patients with dyslipidemia.
Mouth Sounds: A Review of Acoustic Applications and Methodologies
Authors: Naal-Ruiz Norberto E. , Gonzalez-Rodriguez Erick A. , Navas-Reascos Gustavo , Romo-De Leon Rebeca , Solorio Alejandro , Alonso-Valerdi Luz M. , Ibarra-Zarate David I.
Published: March 2023

Mouth sounds serve several purposes, from the clinical diagnosis of diseases to emotional recognition. The following review aims to synthesize and discuss the different methods to apply, extract, analyze, and classify the acoustic features of mouth sounds. The most analyzed features were the zero-crossing rate, power/energy-based, and amplitude-based features in the time domain; and tonal-based, spectral-based, and cepstral features in the frequency domain. Regarding acoustic feature analysis, t-tests, variations of analysis of variance, and Pearson’s correlation tests were the most-used statistical tests used for feature evaluation, while the support vector machine and gaussian mixture models were the most used machine learning methods for pattern recognition. Neural networks were employed according to data availability. The main applications of mouth sound research were physical and mental condition monitoring. Nonetheless, other applications, such as communication, were included in the review. Finally, the limitations of the studies are discussed, indicating the need for standard procedures for mouth sound acquisition and analysis.
IBSA_Net: A Network for Tomato Leaf Disease Identification Based on Transfer Learning with Small Samples
Authors: Zhang Ruofan , Wang Yi , Jiang Ping , Peng Jialiang , Chen Hailin
Published: March 2023

Tomatoes are a crop of significant economic importance, and disease during growth poses a substantial threat to yield and quality. In this paper, we propose IBSA_Net, a tomato leaf disease recognition network that employs transfer learning and small sample data, while introducing the Shuffle Attention mechanism to enhance feature representation. The model is optimized by employing the IBMax module to increase the receptive field and adding the HardSwish function to the ConvBN layer to improve stability and speed. To address the challenge of poor generalization of models trained on public datasets to real environment datasets, we developed an improved PlantDoc++ dataset and utilized transfer learning to pre-train the model on PDDA and PlantVillage datasets. The results indicate that after pre-training on the PDDA dataset, IBSA_Net achieved a test accuracy of 0.946 on a real environment dataset, with an average precision, recall, and F1-score of 0.942, 0.944, and 0.943, respectively. Additionally, the effectiveness of IBSA_Net in other crops is verified. This study provides a dependable and effective method for recognizing tomato leaf diseases in real agricultural production environments, with the potential for application in other crops.
Hierarchical Sliding Mode Control Combined with Nonlinear Disturbance Observer for Wheeled Inverted Pendulum Robot Trajectory Tracking
Authors: Hou Ming , Zhang Xuedong , Chen Du , Xu Zheng
Published: March 2023

A proposed optimized model for the trajectory tracking control of a wheeled inverted pendulum robot (WIPR) system is presented in this study, which addresses the problem of poor trajectory tracking performance in the presence of unknown disturbances due to the nonlinear and underactuated characteristics of the system. First, a kinematic controller was used to track a reference trajectory and generate a control law that specifies the desired forward and rotation speeds of the system. Next, a nonlinear disturbance observer (NDO) was designed to enhance the system’s robustness to external disturbances and improve its tracking performance. Then, the coupled system state variables were decoupled into two subsystems: a forward rotation subsystem and a tilt angle velocity subsystem. An improved hierarchical sliding mode controller was designed to control these subsystems separately. Finally, simulation experiments were conducted to compare the proposed method with a common sliding mode control approach. The simulation results demonstrate that the proposed method achieves better tracking performance in the presence of unknown disturbances.
Study on Crack Propagation of Rock Bridge in Rock-like Material with Fractures under Compression Loading with Sudden Change Rate
Authors: Huang Xuanqi , Wan Wen , Wang Min , Zhou Yu , Liu Jie , Chen Wei
Published: March 2023

In order to study the influence of sudden change of loading rate on crack propagation and failure mode of rock bridge of fractured rock mass, the specimens used in this paper were rock-like materials containing two prefabricated fractures. The mechanical properties and the failure mode of the specimens under different constant loading rates and sudden changes in loading rate were tested. The photographic monitoring and acoustic emission were carried out at the same time. The results show that: (1) In the process of sudden change loading, the specimen shows the characteristics of approximate elastic deformation, and the stress-strain curve after sudden loading is similar to the corresponding stress-strain curve at the corresponding constant loading rate. (2) Combined with acoustic emission detection, it is found that when the loading rate is not much different before the mutation, the loading rates is the same after the mutation and the stress-strain curve of the specimen is similar. In the low-speed loading stage, the acoustic emission count is generally low, while in the high-speed loading stage, the acoustic emission count is generally high. The sudden change from low-speed loading to high-speed loading easily induces stress drop, resulting in crack generation and increase of acoustic emission count. (3) The rate of the specimen during the crack development period plays a decisive role in the failure mode of the specimen. Before the sudden change of loading rate, the low-speed loading within a certain range has little effect on the specimen. When the high-speed loading is carried out when the stress is low in the early stage of the mutation, the acoustic emission count of the specimen is high, which will cause some damage inside the specimen. As a result, even if the rate is the same after the mutation, the final peak stress and failure mode may be different.
Assessment of Deformation Flow in 1050 Aluminum Alloy by the Implementation of Constitutive Model Parameters
Authors: Bátorfi János György , Pál Gyula , Chakravarty Purnima , Sidor Jurij J.
Published: March 2023

The behavior of technically pure aluminum was examined, and this investigation allowed the determination of the material constants by various models. The model parameters derived were subsequently used for the finite element simulations (FEM) of a cold rolling process. To determine the tuning parameters such as the strain-hardening coefficient K, strain-hardening exponent n, or elastic constant E, a tensile test was performed on the heat-treated sheet of 1050 Al alloy and the experimentally observed deformation behavior was compared to the simulated counterpart. The results of the FEM calculations reveal that the strain-hardening characteristics can be alternatively derived from the Brinell indentation. Additionally, the determined constitutive model parameters (E = 69.8 GPa, K = 144.6 MPa, and n = 0.3) were verified by simulating both the symmetric and asymmetric rolling processes. The distribution of the equivalent strain across the sheet thickness was computed by the FEM, and it was found that the modeled deformation profiles tend to reproduce the experimentally observed ones with high accuracy for different strain modes inasmuch as the mentioned rolling trials accommodate diverse amounts of shear and normal strain components.