bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of different acne treatment methods: a comparison of pharmacological, procedural and natural therapies
Authors: Nojek Paweł , Pawlik Wiktoria , Zimonczyk Mariusz , Zawół Monika , Błaszczyński Gustaw , Nowotarska Agnieszka
Published: November 2024

Acne vulgaris is a chronic skin condition affecting millions of people, especially adolescents. This study analyzes the effectiveness of various acne treatment methods, including pharmacological, procedural, and natural therapies. It compares their mechanisms of action, therapeutic effects, and potential side effects. The aim of this study is to identify the most effective therapeutic strategies to improve patients’ quality of life and mental health. The analysis results suggest that a comprehensive approach to acne treatment, combining different methods, may yield the best outcomes.
Evolution and Research Trends in Physical Culture. A Longitudinal Analysis of Student Diploma Theses from the Didactic Team of Physical Culture Sciences, formerly the Department of Physical Culture, Faculty of Earth Sciences and Spatial Management, 2017-2024
Authors: Hagner-Derengowska Magdalena , Michalska Anna , Muszkieta Radosław , Smoleńska Olga , Zukow Walery
Published: November 2024

Objective: The aim of this study was to conduct a comprehensive analysis of diploma theses produced in the Department of Physical Culture at the Faculty of Earth Sciences and Spatial Management between 2017-2024, to identify main research trends, thematic evolution, and assess the impact of external factors on research directions in the field of physical culture.
Material and Methods: The analysis included 95 diploma theses (82 bachelor's and 13 master's). Mixed research methods were applied, combining quantitative and qualitative analysis. Content analysis, statistical analysis (including chi-square tests, analysis of variance, linear regression), and advanced data analysis methods (LDA topic modeling, social network analysis, SARIMA time series analysis) were conducted. Additionally, measures of thematic diversity and supervisor specialization indicators were applied.
Results: A statistically significant upward trend in the number of theses (β = 1.1875, p = 0.0134) and significant seasonality of defenses were found. Five main thematic areas were identified: physical activity and health (29.5%), tourism (23.2%), sport (21.1%), health (15.8%), and recreation (10.5%). LDA analysis revealed more detailed categories, indicating growing interdisciplinarity of research. A significant impact of the COVID-19 pandemic on thesis topics was observed in 2020-2021. Social network analysis showed a key role of certain supervisors in shaping research directions (highest eigenvector centrality = 1.00).
Conclusions: The study revealed dynamic development of the physical culture discipline, with growing emphasis on interdisciplinarity and health aspects. Adaptation of research topics to current social and technological challenges was observed. Results indicate the need for further expansion of the thematic scope of theses, particularly in areas of new technologies and long-term effects of physical activity. The analysis provides valuable information for strategic planning of study program development and research directions in the field of physical culture, tourism, and recreation.
Mighty Children and the Transformation of Authoritative Adults in Andrea Beaty's The Questioneers : A Discussion of Age-Based Power as a Theme in Literature for Children
Authors: Lowery Alyssa Magee
Published: November 2024

Abstract: Andrea Beaty's and David Roberts's The Questioneers series—including Iggy Peck, Architect (2007); Rosie Revere, Engineer (2013); Ada Twist, Scientist (2016); Sofia Valdez, Future Prez (2019); and Aaron Slater, Illustrator (2021)—features imaginative children navigating challenges in pursuit of their goals. This article explores how the series interrogates age-based power dynamics through the interactions between its young protagonists and authoritative adults. Drawing on Maria Nikolajeva's concept of aetonormativity and Clementine Beauvais's formulations of children's might, adults' authority, and the transformation from one to another, this article explores the books' foregrounding of dialogic encounters that transform both children and adults in a renegotiation of age-based power. These encounters occur through Max Weber's three types of legitimate authority: legal, traditional, and charismatic. Through close reading of the five picturebooks in the series alongside theoretical engagements with age, power, and Freirean learning communities, the article considers the arguably irresolvable tension between literature for children that represents those renegotiations of power and its context in the inherently aetonormative structure of children's book publishing.
"There Were Grown-Ups Who Should Have Stopped It": A Youth Theory Analysis of A Wizard's Guide to Defensive Baking
Authors: Seymour Jessica
Published: November 2024

Abstract: A Wizard's Guide to Defensive Baking (2020) by T. Kingfisher is an upper-middlegrade fantasy novel. It opens with a young wizard discovering a corpse in her family's bakery and ends with her leading her city's defense against an army of mercenaries. This article models the application of youth theory to examine aetonormative themes in A Wizard's Guide and concludes that adults' expectations of youth behavior interact with other social norms that are used to disempower and manipulate minority groups. The intersectional nature of youth creates segments of the population that are doubly disempowered, allowing adult power-holders to break the implied promise that they will act in the youths' best interests. Essentially, adults in the narrative can hold the child to cultural expectations of disempowered adults, while simultaneously using the child's age-based powerlessness to ensure their compliance to those expectations. A Wizard's Guide models a society in which intergenerational solidarity has failed, leading young characters to be disenchanted with and traumatized by older generations.
Expansive Ways to Be an Environmental Activist: A Content Analysis of Children's Picturebooks from 2016 to 2022 Surrounding the Climate Crisis
Authors: Fletcher Lauren , Holyoke Erica
Published: November 2024

Abstract: Drawing on a content analysis of 147 picturebooks published from 2016 to 2022, this article examines whose and which stories are told regarding environmental justice and how educators can honor multiple identities in their instruction, advocacy, and actions toward climate justice. The study begins with findings from the analysis across the larger text set of environmental texts in response to the focal questions of environmentalism and environmental justice. It continues with an analysis of three focal picturebooks spanning various global settings. This article advocates for educators, caregivers, and librarians to foster a critical lens with young readers as they engage with environmental texts to raise critique, envision hope, and promote action. We highlight the value of diverse children's literature around environmentalism and environmental justice to support children to delve into the existing breadth of experiences and narratives in known and lesser-known texts. We argue for the need to read across environmentalism picturebooks broadly to foster a more inclusive view of what environmental stewardship is and can be.
Missing Home: Depictions of Exile during the Portuguese Dictatorship
Authors: Ramos Ana Margarida
Published: November 2024

Abstract: The experience of particular types of migration, political exile, and diaspora are mainly portrayed from the refugee's perspective, focusing on the travel process itself or the problems of integration. Despite the interest in this theme emerging only recently, its global persistence and relevance are already considerable and are depicted in relation to different contexts by authors such as Judith Kerr, Peter Sís, and Uri Shulevitz, to name a few. This article thus analyzes the depiction of exile as depicted in two Portuguese illustrated children's books portraying the exile experience during the dictatorial regime.
On (Not) Translating Dogs in Iran
Authors: Farnia Fatemeh (Neda)
Published: November 2024

Abstract: With animal studies and post-humanism, we notice and value the importance of animals in our life, learning to take them seriously as a significant part of our ecosystem. We also try to teach children about the importance of animals in our ecosystem and eradicate any hierarchical relationships toward them. Children's Literature (capping intentional) can aid this process, since so many picturebooks, novels, and other texts written for children and young adults have animals as main characters, or focalizers. Therefore, ecocriticism complements the study of animal characters in Children's Literature. However, in the case of dogs in Iran, in primary sources or school textbooks published for Iranian children, this is rarely possible. The problem is that, based on the Islamic doctrine that dogs are "impure," if one is a faithful believer, one is not supposed to keep them inside the house. So, based on this hierarchical ideology, books with dog characters as pets, living indoors, are censored. This article discusses the treatment of dogs over the centuries in Iran.
An Open World of Stories: A Critical Examination of Open-Access Global Digital Picturebook Platforms
Authors: Naidoo Jamie Campbell , Nixon Gwendolyn C.
Published: November 2024

Abstract: This article presents a critical examination of four open-access global digital picturebook platforms to determine the messages the books could convey to readers about specific cultural groups, and what opportunities are provided for young readers to make important cross-cultural connections to strengthen their socioemotional development and prepare them to engage with diverse individuals in a global society. The sample included five books from each of the open-access platforms. Using both visual content analysis and semiotics, researchers examine how cultures are illustrated—in character demographics, themes, color choices, use of cultural symbols, and any notable differences or similarities between the books in each platform. Each platform was evaluated for its ability to provide opportunities for readers to make important connections with characters in the books, as well as for its potential to support the United Nations Agenda 2030 Sustainable Development Goals of preserving and providing access to the world's culture and heritage. The study provides insight into how children's books in open-access platforms represent different cultures and how this in turn influences the potential for readers to make cross-cultural connections.
Advancing Dental Research in Jordan: The Critical Need for a Specialized Journal
Authors:   Jordan University of Science and Technology, Mukattash Tareq
Published: November 2024

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Effect of sodium perborate treatment on Bond Strength of two resin-based composite systems to pulpal dentine
Authors:   Jordan University of Science and Technology, Maghaireh Ghada , Taha Nessrin , Momani Shatha
Published: November 2024

Objectives: The aim of this study was to assess the effect of treatment with sodium perborate on the shear bond strength of two resin-based composite systems to pulpal dentine. Materials and Methods: Sixty extracted maxillary anterior teeth were divided into six groups (n=10) according to the type of restorative system: etch and rinse adhesive (Adper Single bond 2) with Filtek Z250 or self-etch adhesive (Silorane system Adhesive) with Filtek P90 and bonding protocol (bonding with no sodium perborate, immediate and late bonding). Bond strength was tested in a universal testing machine, and data were analyzed using two-way analysis of variance with independent samples t-test and one-way analysis of variance with Tukey’s HSD post-hoc (p≤0.05). Results: Treatment with sodium perborate significantly lowered the shear bond strength between both composite systems and pulpal dentine, (p<0.001). The mean shear bond strength values were significantly higher in the late bonding compared to the immediate bonding groups for both composites, (p<0.001). Conclusions: Treatment of the pulpal dentine with sodium perborate significantly reduced the immediate shear bond strength between the dentine and composites. The shear bond strength can be returned to nearly normal values if the final bonded restoration is delayed for two weeks after treatment.
Facial Anthropometric Norms of A Young Adult Jordanian Population
Authors:   Jordan University of Science and Technology, Shaweesh Ashraf , Al-Khateeb Susan , Al-Omar Hamed
Published: November 2024

Objectives: This study aimed at establishing and analyzing the first database of facial anthropometric norms specific to a Jordanian population and presenting these norms in a form available for orthodontists and surgeons to use for managing their patients. Methods: Frontal and lateral digital photographs were obtained from 470 young adult Jordanians (317 males and 153 females aged 18 – 40 years). Sixteen facial parameters (6 frontal and 10 lateral parameters) were measured digitally using a custom-designed computer program. Means and standard deviations were calculated for all the measured variables and Students' t-tests were used to calculate the sex differences on the one hand and the age- and sex-specific differences between the studied sample (the Jordanians) and 3 other population groups: Northern Americans, Chinese and African Americans, on the other hand. Results: Except the facial convexity, all measured parameters had statistically significant sex differences, with the males exhibiting higher mean values. The studied Jordanian males and females are different in many of the facial parameters and the Jordanians differ in many of the parameters from people belonging to other populations. In general, The Jordanians, especially males, have greater facial dimensions and variations than the other populations in comparison. Conclusions: The study established the first facial anthropometric database specific for young adult Jordanians. The provided norms will be useful for orthodontist, orthognathic surgeons, plastic surgeons and dysmorphologists in aiding the diagnostic facial recognition of variations and deviations from normal and in planning, performing and following up treatment.
Perceptions of Altered Dental Aesthetics: Influence of ethnicity and time
Authors:   The University of Jordan, Al-Omari Iyad , Hamdan Ahmad , Al-Bitar Zaid
Published: November 2024

Objective: The aims of this study were to assess perceptions of altered dental esthetics by Jordanian orthodontists, general dentists (GD) and laypeople (LP) and to compare them with the original data derived around a decade ago by Kokich et al. (2, 3) from an American sample. Materials and Methods: Photographs of 8 symmetric and asymmetric altered anterior dental esthetics were used. Symmetric alterations were incisor angulations (IA), lip to gingiva distance (GS) and bilateral papillary height of the maxillary anterior teeth (BPH) while asymmetric alterations were midline (ML), crown length (CL), crown width (CW), crown width and length (WL) and papillary height (UPH). Photographs were rated by a sample orthodontists, GD and LP. Raters were also asked to rank different dentofacial features according to their esthetics focus. Results: Thresholds for detection of IA, GS, and WL alterations were similar in all groups. However, orthodontists had the lowest detection threshold for ML. Orthodontists and LP had lower thresholds for BPH and UPH than GDs. However, CL and CW thresholds were lower for orthodontists and GDs. The most noticeable dentofacial feature was tooth position for orthodontists and eye color for GDs and LP. Conclusions: Orthodontists were more sensitive to deviations than general dentists and laypeople irrespective of their ethnic and cultural background. Jordanian raters were more sensitive to deviations of the midline, gingiva to lip distance and unilateral papillary height from ideal. Jordanian raters were generally more critical of discrepancies compared to their American counterparts.
Color masking and caries inhibition effects of resin infiltration, case report
Authors:   The University of Jordan, Abd Alraheam Islam , Nguyen Caroline , Irusa Karina , Ghuman Taneet , Donovan Terry
Published: November 2024

Introduction/objectives: white spot lesions (WSL) are enamel defects that can lead to esthetic concerns when located on facial surfaces of anterior teeth. In recent years, resin infiltration has been suggested as a treatment to mask WSL and arrest non-cavitated initial carious lesions. This narrative review aims to summarize the current literature on this technique. Data source: an electronic search on Pubmed, Embase and Scopus databases was conducted for human randomized clinical trial (RCT), prospective and retrospective cohort studies, reviews, meta-analysis, case reports, and in vitro studies. The key words used in the search were: Resin infiltration, White spot lesion, White spot lesions and caries. Results: the current literature suggests that resin infiltration might be an effective treatment to mask white spot lesions and arrest initial non-cavitated carious lesions. The concept of infiltrating carious lesions aims to occlude the porosity in the carious lesion thus inhibiting the diffusion of cariogenic acids. This procedure utilizes capillary forces to carry methacrylate resins (infiltrants) with high penetration coefficients into the porous enamel. The resin refractive index is closer to the refractive index of enamel, which gives this material the ability to mask white spot lesions. Conclusion: color masking with resin infiltration seems successful and stable in the short-term. However, more clinical data is needed to report long-term masking effect.
A multi-trait targeted genotype selection approach for screening drought tolerance in teosinte–maize hybrids
Authors: Jaishreepriyanka R , Ravikesavan R , Iyanar K , Uma D , Senthil N
Published: November 2024

Drought tolerance is a complex characteristic and screening based on multiple traits rather than direct selection indices would result in more efficient selection. The study aims to select hybrids under optimal and water deficit conditions to achieve genetic gains in yield traits without compromising the other secondary traits viz., anthesis-silking interval, leaf chlorophyll content, delayed leaf rolling and leaf senescence, relative water content, and ROS scavenging using the multi-trait genotype ideotype distance index. The 30 teosinte-maize hybrids along with four checks were evaluated for two classes of traits: 16 morphometric and 14 physiological and biochemical traits, under well-watered (WW) and water-stress (WS) environments. Significant variations among the genotypes were observed for most traits and the presence of moderate to high heritability for most traits suggests direct selection for improvement of those traits. Significant correlation of the traits with yield and intercorrelations between traits indicate the advantage of indirect selection based on secondary traits. By assuming a selection intensity of 15% and equal weightage to all the traits, five genotypes were selected based on the MGIDI under each class of traits and in each environment. The genotypes viz. G19, G20, and G29 were commonly selected across both environments. The selection led to desired positive and negative selection gains for most of the traits studied and resulted in high positive gains for single plant yield of 35.6% under WW and 69.3% under WS. The strength and weakness plots effectively present the advantages and limitations of the selected genotypes under each environment. The multi-trait-based selection approach is an effective tool for selecting genotypes and designing breeding strategies for stress breeding.
Soil zinc dynamics over time on applied organics, bacterial inoculant and zinc fertilizers in calcareous soil of southern India
Authors: Bose K Subash Chandra , Selvi D , Vinothini R , Balaganesh B , Kumar V Vinoth , Venkatesh V , Kumaran V R Senthamizh
Published: November 2024

Bioavailability of zinc was impacted by soil properties, externally applied sources, time, and various fractions of zinc. An experiment was conducted to investigate the bioavailable and other zinc fractions in calcareous soil and the efficiency of organic and inorganic sources on bioavailability with the presence and absence of zinc solubilizing bacteria (ZSB). The sequential extraction procedure followed at every interval of the incubation period for all forms of zinc was studied. Externally added inorganic sources significantly affected all fractions of zinc compared to untreated soils. Among them, ZnSO4 influences all forms of zinc, mainly Ws+Ex (water soluble+exchangeable) and carbonate-bound zinc, whereas Zn-EDTA maintains a high status of bioavailable zinc throughout the experimental period. On the 60th day of incubation, Zn-EDTA and ZnSO4 applied to soil maintained bioavailable zinc content of 3.71 and 2.94 times higher than that of control. Irrespective of sources, the available zinc of Zn fertilizers applied to soils was reduced with an increase in incubation days. Organic and microbial addition effects solely or combined increase the soil zinc content significantly in both fertilized and unfertilized soils. Among two different organic sources, the zinc solubility performance of farmyard manure was higher than that of vermicompost. In untreated soil, residual and carbonate-bound fractions contribute a major portion towards total zinc based on quantity. The bioavailable fraction mainly the Ws+Ex and organically bound fractions were markedly influenced in all treatments.
Effect of fertigation scheduling and doses of NPK on growth, yield and quality of cherry tomato (Solanum lycopersicum L. var. cerasiforme) under protected condition
Authors: Selvaganapathi S , Kumar GA , Vethamoni PI , Rani CI , Pazhanivelan S , Sundar STB , Vanitha K
Published: November 2024

This study investigated the impact of different fertigation schedules on cherry tomato (Solanum lycopersicum var. cerasiforme) cultivation in a controlled environment at TNAU, Coimbatore, India. A Completely Randomized Design with nine treatments and three replications was used, incorporating various combinations of soil application and fertigation with water-soluble fertilizers at 25%, 50%, 75%, and 100% of the recommended dose of fertilizer (RDF). Critical parameters such as growth, phenological traits, yield, fruit quality, soil nutrient status, and plant nutrient uptake were evaluated. Statistical analyses, including ANOVA, path coefficient analysis, and principal component analysis (PCA), were performed to assess treatment effects and identify relationships between variables. The results consistently demonstrated that fertigation with water-soluble fertilizers at 100% RDF (T3) yielded the best outcomes for most parameters, followed by 75% RDF fertigation (T4) and a combination of 25% soil application and 75% fertigation (T7). Significant improvements in plant growth, yield and fruit quality were observed with optimized fertigation compared to traditional soil application methods. T3 (100% RDF through fertigation) resulted in the highest plant height (263.95 cm), number of primary branches (15), leaf area (316.77 cm²) and dry matter production (96.85 kg/plant). Yield attributes such as fruits per plant (326.50), fruit weight (3.73 g), and total yield (23.95 t/ha) were also highest in T3. Path coefficient analysis indicated strong positive correlations between growth and yield parameters. PCA showed that the first principal component accounted for 85.9 % of the total variation. These findings highlight the potential for fertigation to improve resource use efficiency and productivity in cherry tomato cultivation.
Response surface methodology-based optimization of hairy roots cultures for in vitro AM production
Authors: PV Priya , Kumutha K , Subhashini R , Renuka R , Sivakumar T , Kannan P
Published: November 2024

Arbuscular mycorrhizal fungi can do wonders in promoting the crop growth as well maintaining soil health. In vitro root organ culture technology is an exciting avenue for AM biofertilizer production.  This study aims to optimize the key influencing factors for enhancing the hairy root production used for in vitro AMF culturing using response surface methodology, a statistical and mathematical tool used for designing optimization studies. Study uses Rhizobium rhizogenes MTCC 2364 for transformation in carrot explant. Factors considered for optimization are concentration of gelling agent (phytagel), carbon source (sucrose) and pH of the Modified Strullu and Romand medium (MSR). Design Expert software uses second order polynomial regression equation for predicting the outcome of each experiment. Totally, 17 experiments were run following Box-Behnken design and average hairy root length and average side branch emergence were taken as response. ANOVA analysis reveals that the concentration of phytagel and sucrose had a strong influence on root length, while the phytagel and pH of the medium had a strong effect on side branch emergence. Overall, taking into account the both responses, concentration of phytagel had a significant impact on hairy root production. The maximum average hairy root length obtained was 1.12 cm and number of side branches emerged were 6.78 per day. Based on these results, the optimal parameters were MSR medium with 3gL-1 phytagel, 11gL-1 sucrose and a pH of 4 for boosting hairy root development. This study is a cost-effective approach and minimizes the time taken for establishing the hairy root technology.
Paul Veenvliet & Jana Kus Veenvliet: Dvoživke Slovenije: priročnik za določanje. Symbiosis - Zavod za naravovarstveno raziskovanje in izobraževanje, Grahovo. 74 str.
Authors: Janžekovič Franc
Published: November 2024

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Distributed cognition in oral poetry improvisation: a semiosis-centered approach
Authors: Atã Pedro , Queiroz João
Published: November 2024

We propose a semiotic externalist approach that takes cognition as semiosis, gives central importance to the notion of temporal distribution, describes the elements of distributed cognitive systems (DCSs) as signs, and identifies the DCS itself as a system that enacts a sign. This is a semiosis-centered, and thus a non-agent-centered account of DCSs. In order to develop and illustrate our argument, we describe an example of DCS – the Brazilian verbo-musical improvisational tradition of repente – considering it first as embodiment of the formal structure of a cognitive task, and then as embodiment of a semiotic process. The latter corresponds to a semiotization of the description of repente sessions as DCSs, that focuses on how the DCS can embody a meta semiotic process, semiosis that supervenes on, and determines, distinct types of smaller-scale semiotic process.
Externalization of the mind in the meaning-making process: An integrated semiotic and cognitive science perspective
Authors: Magnani Lorenzo , Biglari Amir
Published: November 2024

This article seeks to outline the effective integration of semiotic methods, particularly the Peircean approach, with research on human creative cognition. The aim is to elucidate the involvement of the mind and neurological mechanisms in the process of semiosis. By examining how the mind externalizes thoughts and ideas, the article offers a fresh perspective on how external models and representations serve as essential anchors of meaning. Furthermore, this integrated approach provides a deeper understanding of how meaning is constructed and communicated, highlighting the importance of considering both internal cognitive processes and external manifestations in the study of semiotics.
Image modeling algorithm for environment design based on augmented and virtual reality technologies
Authors: Gong Da , Chen Tong , Zhou Shuxin , Han Jiaheng , Li Zhenghang
Published: November 2024

With the continuous development of computer vision technology, the image modeling of environmental design has also received more and more attention. This study proposed an image modeling algorithm for environment design based on augmented reality (AR) and virtual reality (VR) technologies. On the system architecture, the environment design image modeling algorithm based on AR and VR technologies has provided users with an immersive 3D simulation space environment. It also has provided users with a good interactive interface through AR technology, enabling users to interact with computers in a realistic virtual three-dimensional environment and interactive operation. This study verified the algorithm from three aspects: time, authenticity, and interactivity. When facing object A, the modeling time values of the traditional environmental design image modeling method and the environmental design image modeling method proposed in this study were 12.14 and 8.72 s, respectively. The modeling authenticity reached 87.51 and 98.57%, respectively, and the interactivity reached 79.14 and 96.45%, respectively. Some columns of data have proved that the environmental design image modeling method proposed in this study was superior to the traditional environmental design image modeling method. In addition, this study also verified the system model from three aspects: stability, running smoothness, and performance loss. When the number of image modeling in the environment design was 2, the stability, running smoothness, and performance loss of the system were 99.37, 99.25 and 0.75%, respectively. The experimental data again proved that the algorithm system model proposed in this study was feasible and worthy of further application.
Applications of integrating artificial intelligence and big data: A comprehensive analysis
Authors: Almanasra Sally
Published: November 2024

The integration of artificial intelligence (AI) and big data technologies has the potential to revolutionize various industries, yet there are complexities and challenges associated with their implementation. This comprehensive study aims to investigate the combined impact of AI and big data on operational efficiency, precision, and security across multiple sectors. By utilizing a methodological analysis of 105 peer-reviewed articles sourced from reputable databases, we systematically explore the diverse applications, key innovations, and transformative potential of these technologies. Our findings uncover significant advancements in healthcare diagnostics, drug discovery, personalized education, and smart farming, highlighting how AI enhances big data analytics to drive notable improvements. Specifically, the study reveals the accuracy of AI in healthcare diagnostics, the efficiency of big data in drug discovery, the personalization of learning experiences through AI in education, and the sustainability advancements in agriculture through smart farming. These results underscore a substantial shift toward more sophisticated data-driven decision-making and operational processes facilitated by the integration of AI and big data. This shift addresses the initial research problem and makes a significant contribution to both academic and practical understanding of the role these technologies play in shaping the future of industry operations. The study concludes that while AI and big data integration offers substantial benefits, addressing associated challenges is crucial for maximizing their impact.
The role of neopterin in cross-talk between tumor and tumor microenvironment in hepatocellular carcinoma
Authors: Satılmış Basri , Çiçek Egemen , Karakaş Serdar , Kutlutürk Koray , Otan Emrah , Yılmaz Sezai , Şahin Tevfik Tolga
Published: November 2024

Neopterin is a marker of activated immune response, but its role in hepatocarcinogenesis is unknown. The present study aims to evaluate the effects of neopterin on prooncogenic/proinflammatory, apoptotic pathways, and other molecular mechanisms in HCC. We used SNU449, Huh-7, SK-Hep-1, and HepG2 cell lines. A cell viability assay was performed with different concentrations of neopterin. RT-PCR, Western blotting, transwell migration, scratch assay, and reactive oxygen species (ROS) production assays were performed at inhibition concentration 50 of neopterin, which was 40 µM for SNU449 and 80 µM for other cell lines. There were significant changes in mTOR, STAT3, PI3K, and interleukin-6 gene expressions, which were also supported by the protein expressions. Neopterin did not affect apoptosis in SNU449, while apoptosis increased by all doses of neopterin in SK-Hep-1 and HepG2. ROS production was increased in all cell lines in response to neopterin. Cell migration was reduced in SK-Hep1 and HepG2 but did not change in SNU449 and Huh-7. Our study showed that neopterin is not just a byproduct. The results suggest that neopterin may be a paracrine factor that modulates pro-inflammatory and pro-oncogenic pathways responsible for the biological behavior of HCC in a chronic inflammatory tumor microenvironment.
The Limits of Reconciliation: Achilles, Cyrus, and the Secret of Tact
Authors: Konstan David , Nieto Pura
Published: November 2024

This paper examines the tension between Cyrus and Cyaxares in Xenophon’s Cyropaedia, and the ways in which Cyrus succeeds in mollifying the Median king (and his maternal uncle), who is angry because Cyrus has usurped his authority. It argues that, although Cyrus has been charged with deceit in his effort to conciliate Cyaxares, in fact such dissembling is ineliminable where there is a genuine offense to another’s honor. It suggests further that the episode is a deliberate rejoinder to the conflict between Achilles and Agamemnon, as described in the Iliad, and is intended to show how properly to resolve a clash between a king and his more warlike subordinate.
Presentación
Authors: Guerrero Agripino Luis Felipe
Published: November 2024

Nos congratulamos presentando el número 25 de nuestra revista Ciencia Jurídica, donde ofrecemos a nuestros lectores un análisis profundo sobre temas actuales y de gran relevancia en el ámbito jurídico, abarcando desde problemáticas vinculadas a los derechos humanos hasta el impacto legal del uso de nuevas tecnologías, como es el caso de los NFTs. De esta forma, manteniendo el espíritu de nuestra publicación invitamos a la reflexión crítica sobre el sistema de justicia, el marco legal de derechos humanos, y otros aspectos fundamentales del derecho.
Verdad y Realidad en el Sistema de Justicia Penal
Authors: Guerrero Agripino Luis Felipe , Zamarripa Aguirre Carlos
Published: November 2024

Se suele pensar que en el sistema de justicia es posible llegar a conocer la verdad de los hechos y sobre esa base asumir el tratamiento y las consecuencias jurídicas. No obstante, llegar a esa verdad tiene inconvenientes epistémicos; en virtud de ello se debe tener especial cuidado en el diseño de la averiguación de los hechos, optimizar los recursos técnicos-multidisciplinarios y tener siempre a la vista el respeto a los derechos humanos.
Respeto a los Derechos Humanos de la Policía en el Sistema Mexicano. Un Enfoque Infrecuente
Authors: Guerrero Agripino Luis Felipe , Huett López Sophia
Published: November 2024

En un estado democrático, es de primordial importancia el respeto de los derechos humanos a la ciudadanía por parte de la policía, y también el reconocimiento de los derechos humanos de la policía. El presente trabajo se ubica en esta segunda vertiente, para lo cual se hace un análisis de nueve derechos que se encuentran regulados en un instrumento emitido por la Comisión Nacional de Derechos Humanos, a partir de datos objetivos derivados de instancias oficiales.
Miramax, LLC vs. Quentin Tarantino y Romantica, INC
Authors: Rivero Silva Sebastián
Published: November 2024

El presente trabajo analiza el caso MIRAMAX LLC., Vs. QUENTIN TARANTINO & ROMANTICA, INC., derivado de la generación de NFTs de fragmentos inéditos del guion original de la película Pulp Fiction y la comercialización de éstos por parte de Quentin Tarantino, sin la aprobación de MIRAMAX, LLC. A lo largo del trabajo, se estudia el marco legal aplicable a las obras cinematográficas y los NTFs, poniéndolos en contexto con el caso objeto de análisis. Para ello se parte de la base de que aquellos fragmentos inéditos del guion original tokenizados, constituían derechos contractualmente reservados por Tarantino, quien no solo fue el director de la película sino co-autor del guion original.
Reglas, Principios y el hondo abismo que existe entre los dos
Authors: Rodríguez Durón Jesús Everardo
Published: November 2024

En el presente artículo se explora la virtualidad de la tesis de la distinción lógica entre reglas y principios conforme a una de sus presentaciones más difundidas; esto es, la teoría de los mandatos de optimización de Robert Alexy. No obstante, se sostiene que la tesis fuerte de la distinción no logra su objetivo, porque entre ambas especies normativas existe solo una diferencia gradual relacionada con la aplicación de una convención interpretativa.
Nombre como Derecho Humano y su modificación en Niñas, Niños y Adolescentes
Authors: Aude Díaz Roberto , Sosa Ordaz María Alejandra , Matrón Saenz Jorge Martín
Published: November 2024

El nombre constituye un atributo de la personalidad y, a la vez, un derecho humano, por lo que este va más allá de ser un medio para la identificación de una persona. La legislación civil contempla su modificación vía administrativa a un número limitado de casos, por lo que aquellos supuestos que no encuadren en las hipótesis previstas, deberán intentarlo en vía jurisdiccional. Ahora bien, la vía administrativa prevé supuestos en los que no se efectúe un cambio sustancial en el nombre, pese a que ello puede generar afectaciones a la dignidad humana, en especial, tratándose de niños, niñas y adolescentes. Así, el presente artículo expone un caso que explica cómo se debe velar por el interés superior de la infancia cuando existan nombres que puedan atentar contra su dignidad, así como la necesidad de que se prevean mecanismos sencillos y rápidos para ese efecto, evitando una vulneración mayor a sus derechos humanos.
Impacto de las Candidaturas Independientes en Guanajuato: Una revisión constitucional y convencional
Authors: Mata Miranda Armando Ramón
Published: November 2024

A partir de la incorporación de las candidaturas independientes en el ordenamiento constitucional y electoral –a nivel federal y local–, para contender a cargos de elección popular, se han presentado diversas problemáticas en la operatividad de esta figura como mecanismo para garantizar los derechos políticos-electorales de los ciudadanos. Por tal motivo, se estima relevante analizar cuál ha sido el impacto de esta figura en los procesos electorales locales. Lo anterior, a fin de identificar algunas pautas que permitan potencializar sus alcances en el Estado de Guanajuato.
Abandono de Bienes en el Código Nacional de Procedimientos Penales
Authors: Gavia Freyre José Antonio
Published: November 2024

El abandono de bienes es una herramienta jurídica poco explorada y por tanto explotada por los entes de procuración de justicia. No obstante, en ella encontramos un medio adicional para hacer frente a la criminalidad en lo que hace al debilitamiento de las denominadas estructuras financieras de los grupos delincuenciales. Esta circunstancia representa un área de oportunidad en el combate integral contra las conductas lesivas que son desarrolladas por esas organizaciones, puesto que ´junto con el decomiso y la extinción de dominio, son un complemento de la labor del Estado para poder llevar a cabo la recuperación de activos, así como una reconducción para que dichos activos tengan una finalidad lícita. Por lo cual, resulta necesario establecer algunas consideraciones que detallen, desde el punto de vista práctico, la operatividad del abandono bienes a la luz de nuestro marco jurídico, con la intención de que se incentive su utilización.
ЭКОЛОГИЧЕСКИЕ ФАКТОРЫ И ДЕНИТРИФИЦИРУЮЩИЕ БАКТЕРИИ ЭПИЛИТОНА ОЗЕРА БАЙКАЛ
Authors: А.С. ГОРШКОВА , Г.В. ПОДЛЕСНАЯ , Н.А. ЖУЧЕНКО , И.В. ТИХОНОВА , М.Ю. СУСЛОВА , Ю.Р. НЕБЕСНЫХ , Е.А. ЗИМЕНС , О.И. БЕЛЫХ
Published: November 2024

Эпилитные биопленки играют важную роль в водоемах, участвуя в круговороте питательных веществ. Денитрификация активно протекает в эпилитоне водоемов. Однако информация об экологических факторах, влияющих на данный процесс в биопленках, весьма ограниченна. В настоящей работе исследована численность культивируемых денитрифицирующих бактерий в биопленках, сформированных на каменистых субстратах, в различных районах литорали оз. Байкал. Выявлено, что основными факторами, объясняющими различия в количестве культивируемых бактерий, осуществляющих полную денитрификацию, были температура и концентрация общего азота в придонном слое воды. Показано, что меньшее количество денитрификаторов характерно для биопленок, испытывающих дефицит азота, на что указывало низкое стехиометрическое соотношение N : P в биопленках. Определено неравномерное распределение тяжелых металлов в биомассе эпилитных биопленок, что также может потенциально влиять на денитрификацию в эпилитоне оз. Байкал.

Participating in the circulation of nutrients epilithic biofilms play an important role in water bodies. Denitrification actively proceeds in the epilithon of water bodies. However, the information on environmental factors that affect the process in biofilms is still limited. The object of study in this article involves the number of cultivated denitrifying bacteria in biofilms formed on the stony substrates in different parts of Lake Baikal littoral zone. It has been found out that the main factors explaining the differences in the number of cultivated bacteria who perform complete denitrification were the temperature and the concentration of total nitrogen in shallow water. The article shows that lower amount of denitrifiers is a typical for biofilms experiencing nitrogen deficiency as indicated by the low stoichiometric N: P ratio in biofilms. An uneven distribution of heavy metals in the biomass of epilithic biofilms has been determined. It also may potentially impact denitrification in the epilithon of Lake Baikal.
ТАКСОНОМИЧЕСКОЕ РАЗНООБРАЗИЕ МИКРОБНОГО СООБЩЕСТВА В ТЕРМАЛЬНОМ ИСТОЧНИКЕ КУЧИГЕР (БАЙКАЛЬСКАЯ РИФТОВАЯ ЗОНА)
Authors: Е.В. ЛАВРЕНТЬЕВА , А.А. РАДНАГУРУЕВА , О.А. БАТУРИНА , В.В. ХАХИНОВ
Published: November 2024

Гидрохимический и микроэлементный состав воды и донных осадков был определен в транзитной зоне смешения подземных и поверхностных вод в термальном источнике Кучигер (Байкальская рифтовая зона). Поступление химических веществ с подземными водами и высокие температуры создают благоприятные и специфические условия для развития микроорганизмов. Изучено таксономическое разнообразие микробного сообщества воды и донных осадков с использованием анализа ампликонов гена 16SрРНК . Проанализировано 107 619 нуклеотидных последовательностей, отнесенных к 211 ОТЕ. В изученных образцах воды и донных осадков доминировали бактерии, представители архей составляли 0,2-3,1 %. В микробных сообществах филум Proteobacteriaявлялся доминирующим. Субдоминантами в изученных образцах являлись филумы Firmicutes, Chloroflexi, Nitrospirae, Acetothermia и Actinobacteria, где их соотношение варьировало в зависимости от биотопа. Характерная особенность микробного сообщества в термальном источнике Кучигер - доминирование хемолитотрофных бактерий.

The hydrochemical and microelement composition of water and bot tom sediments was determined in the Kuchiger thermal spring (Baikal rift zone). The entry of chemicals with groundwater and high temperatures create favorable and specific conditions for the development of microorganisms. The taxonomic diversity of the microbial community of water and bottom sediments was studied using the analysis of 16S rRNA gene aplicons. 107619 nucleotide sequences assigned to 211 OTUs were analyzed. In the studied samples of water and bottom sediments, bacteria dominated, representatives of archaea accounted for 0.2-3.1 %. The phylum Proteobacteria dominated in microbial communities. The subdominants in the studied samples were the phyla Firmicutes, Chloroflexi, Nitrospirae, Acetothermia, and Actinobacteria, where their ratio varied depending on the biotope. A characteristic feature of the microbial community in the Kuchiger thermal spring is the dominance of chemolithotrophic bacteria.
ПАРАМЕТРЫ ОСЕННЕЙ МИГРАЦИОННОЙ ОСТАНОВКИ МОЛОДЫХ ВАРАКУШЕК (LUSCINIA SVECICA LINNAEUS, 1758) В УСЛОВИЯХ СРЕДНЕЙ ТАЙГИ В ВОСТОЧНОЙ ЧАСТИ РУССКОЙ РАВНИНЫ
Authors: Г.Л. НАКУЛ
Published: November 2024

В 2015-2019 гг. осуществлен отлов молодых варакушек с целью определения параметров их миграционной остановки (сроки и динамика пролета, длительность миграционной остановки, линька в процессе миграции и скорость жиронакопления птиц во время миграционной остановки) в условиях таежной зоны на востоке Русской равнины. Проанализированы данные первичных и повторных отловов 272 птиц, из которых в выборку включены данные 186 самцов и 86 самок. Средняя длительность миграционной остановки для молодых варакушек составила 1,45 дня. Транзитные особи имеют жировые резервы, которые позволяют им совершать миграционные броски длительностью в среднем 4,39 ± 0,20 ч. Варакушки со средней длительностью остановки имеют скорость жиронакопления 0,04 ± 0,36 г в сутки и к моменту отлета способны совершать миграционные броски длительностью в среднем 3,89 ± 0,58 ч. Особи, которые принимают решение об остановке, незначительно теряют свои жировые запасы, уменьшая свои возможности к миграционному броску до следующего места. Значимость речных долин на востоке Русской равнины для успешной миграционной остановки до конца не выяснена, так как непонятно, обладают ли они теми необходимыми экологическими условиями, оказывающими влияние на параметры остановки мелких птиц.

In 2015-2019 catching of young bluethroats was carried out in order to determine the parameters of their migration stop in the taiga zone in the east of the Russian Plain. A total of 272 birds were analyzed, of which 186 were males and 86 were females. The average duration of the migration stop for young bluethroats was 1.45 days. Transient individuals have fat reserves that allow them to make migratory throws lasting an average of 4.39 ± 0.20 hours. Bluethroats with an average stopping time have a fat accumulation rate of 0.04 ± 0.36 g per day and by the time of departure are able to make non-stop flights lasting an average of 3.89 ± 0.58 hours. Individuals that make the decision to stop lose little of their fat reserves, reducing their ability to fly non-stop until the next stop. The significance of the river valleys in the east of the Russian Plain for a successful stopover remains open, and it has not been fully clarified whether these places have the necessary ecological conditions for the successful stopover of small birds.