bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactions of graphene oxide and graphene nanoplatelets with the in vitro Caco-2/HT29 model of intestinal barrier
Authors: Domenech Josefa , Hernández Alba , Demir Esref , Marcos Ricard , Cortés Constanza
Published: February 2020

Carbon-based nanomaterials are being increasingly used, demanding strong information to support their safety in terms of human health. As ingestion is one of the most important exposure routes in humans, we have determined their potential risk by using an in vitro model simulating the human intestinal barrier and evaluated the effects of both graphene oxide (GO) and graphene nanoplatelets (GNPs). A coculture of differentiated Caco-2/HT29 cells presenting inherent intestinal epithelium characteristics (i.e. mucus secretion, brush border, tight junctions, etc.) were treated with GO or GNPs for 24 h. Different endpoints such as viability, membrane integrity, NPs localization, cytokines secretion, and genotoxic damage were evaluated to have a wide view of their potentially harmful effects. No cytotoxic effects were observed in the cells that constitute the barrier model. In the same way, no adverse effects were detected neither in the integrity of the barrier (TEER) nor in its permeability (LY). Nevertheless, a different bio-adhesion and biodistribution behavior was observed for GO and GNPs by confocal microscopy analysis, with a more relevant uptake of GNPs. No oxidative damage induction was detected, either by the DCFH-DA assay or the FPG enzyme in the comet assay. Conversely, both GO and GNPs were able to induce DNA breaks, as observed in the comet assay. Finally, low levels of anti-inflammatory cytokines were detected, suggesting a weak anti-inflammatory response. Our results show the moderate/severe risk posed by GO/GNPs exposures, given the observed genotoxic effects, suggesting that more extensive genotoxic evaluations must be done to properly assess the genotoxic hazard of these nanomaterials.
Indicators of retention in remote digital health studies: a cross-study evaluation of 100,000 participants
Authors: Pratap Abhishek , Neto Elias Chaibub , Snyder Phil , Stepnowsky Carl , Elhadad Noémie , Grant Daniel , Mohebbi Matthew H. , Mooney Sean , Suver Christine , Wilbanks John , Mangravite Lara , Heagerty Patrick J. , Areán Pat , Omberg Larsson
Published: February 2020

Digital technologies such as smartphones are transforming the way scientists conduct biomedical research. Several remotely conducted studies have recruited thousands of participants over a span of a few months allowing researchers to collect real-world data at scale and at a fraction of the cost of traditional research. Unfortunately, remote studies have been hampered by substantial participant attrition, calling into question the representativeness of the collected data including generalizability of outcomes. We report the findings regarding recruitment and retention from eight remote digital health studies conducted between 2014–2019 that provided individual-level study-app usage data from more than 100,000 participants completing nearly 3.5 million remote health evaluations over cumulative participation of 850,000 days. Median participant retention across eight studies varied widely from 2–26 days (median across all studies = 5.5 days). Survival analysis revealed several factors significantly associated with increase in participant retention time, including (i) referral by a clinician to the study (increase of 40 days in median retention time); (ii) compensation for participation (increase of 22 days, 1 study); (iii) having the clinical condition of interest in the study (increase of 7 days compared with controls); and (iv) older age (increase of 4 days). Additionally, four distinct patterns of daily app usage behavior were identified by unsupervised clustering, which were also associated with participant demographics. Most studies were not able to recruit a sample that was representative of the race/ethnicity or geographical diversity of the US. Together these findings can help inform recruitment and retention strategies to enable equitable participation of populations in future digital health research.
Targeting the αv Integrins in Fibroproliferative Disease
Authors: Nanthakumar C. B. , Hatley R. J. D. , Slack R. J.
Published: February 2020

Fibrosis is the formation of abnormal scar tissue following repeated tissue injury, leading to the disruption of extracellular matrix homeostasis with loss of tissue architecture and function. In the developed world, fibrosis is a leading cause of morbidity and mortality whereby multiple organs can be individually affected. Over the last decade the αv integrins have emerged as a target class with significant potential to intervene in multi-organ fibrosis due to their role in the activation of the key pro-fibrotic cytokine, transforming growth factor-β. Although drug discovery efforts have been directed at members of this integrin sub-family in the past, the αv integrins are currently undergoing a renaissance due to recent compelling target validation in fibrotic diseases. Historical drug discovery initiatives highlighted the challenges in both chemical tractability and design of robust pre-clinical and clinical studies in this area. The majority of approved drugs have targeted the αIIbβ3 integrin for thrombosis, which demonstrates that only a small proportion of the integrin family have been shown to be tractable drug targets, probably as a result of their complex functional roles in both normal physiology and disease pathobiology. Recently, there has been large investment by the pharmaceutical industry into αv-integrin drug discovery research that has facilitated the advancement of new small molecule therapeutics to clinical use. The aim of this chapter is to summarise the evidence for the αv integrins in fibrotic disease, offer insight into αv inhibitor small molecule drug design and provide an overview of the competitor and clinical landscapes to date.
Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators
Authors: Lamers Christina , Merk Daniel
Published: February 2020

Farnesoid X receptor acts as bile acid sensing transcription factor and has been identified as valuable molecular drug target to treat severe liver disorders, such as non-alcoholic steatohepatitis (NASH). Preclinical and clinical data indicate anti-fibrotic effects obtained with FXR activation that also appear promising for other fibrotic diseases beyond NASH. Strong efforts in FXR ligand discovery have yielded potent steroidal and non-steroidal FXR activators, some of which have been studied in clinical trials. While the structure–activity relationship of some FXR agonist frameworks have been studied extensively, the structural diversity of potent FXR activator chemotypes is still limited to a handful of well-studied compound classes. Together with safety concerns related to full therapeutic activation of FXR, this indicates the need for novel innovative FXR ligands with selective modulatory properties. This chapter evaluates FXR's value as drug target with emphasis on fibrotic diseases, analyses FXR ligand recognition and requirements and focuses on the discovery and structural refinement of leading FXR activator chemotypes.
Galectin-3 Involvement in Fibrotic Diseases
Authors: Jiang Xiaosong , Torok Natalie J. , Barchi Jr Joseph J.
Published: February 2020

A variety of signaling pathways contribute to initiating the pathologies associated with fibrotic disease. Galectins are a group of beta-galactoside-binding proteins that are involved in a host of cellular processes, some of which contribute to fibrosis in different organs. Accumulating evidence indicates that of these, Galectin-3 (Gal-3) is a pathogenic mediator in fibrotic diseases in many different organs. The atypical Gal-3 contains a single carbohydrate recognition domain (CRD) attached to an N-terminal peptide sequence that putatively nucleates the formation of oligomers that can form lattice networks when bound to multiple cellular glycans. Pharmacological or genetic knockdown of Gal-3 has been shown to inhibit fibrosis in several organs, and thus has emerged as a valid therapeutic target. This chapter will review the structure and function of Gal-3 and attempt to validate the important role it plays in fibrosis. In addition, the current state of pharmaceutical discovery of Gal-3 inhibitors will be outlined and discussed in the context of fibrotic disease of the heart, liver, lungs and kidneys. A discussion of the challenges facing future Gal-3 inhibitor development for targeting fibrosis will also be included.
Hydrogel 3Din vitrotumor models for screening cell aggregation mediated drug response
Authors: Monteiro Maria V. , Gaspar Vítor M. , Ferreira Luís P. , Mano João F.
Published: February 2020

Hydrogel-based 3Din vitromodels comprising tumor ECM-mimetic biomaterials exhibit differential responses to therapeutics according to cancer cells cellular aggregation state.
Three-dimensional printing of black phosphorous/polypyrrole electrode for energy storage using thermoresponsive ink
Authors: Xing Ruizhe , Xia Yinqiang , Huang Renliang , Qi Wei , Su Rongxin , He Zhimin
Published: February 2020

A new thermoresponsive black phosphorous nanosheet/polypyrrole composite ink was developed for constructing a three-dimensionally printed supercapacitor electrode.
Double trouble for viruses: a hydrogel nanocomposite catches the influenza virus while shrinking and changing color
Authors: Randriantsilefisoa Rotsiniaina , Nie Chuanxiong , Parshad Badri , Pan Yuanwei , Bhatia Sumati , Haag Rainer
Published: February 2020

We report a virus responsive hydrogel with a dual response.
An air-stable anionic two-dimensional semiconducting metal-thiolate network and its exfoliation into ultrathin few-layer nanosheets
Authors: Zeng Qi , Wang Lei , Huang Yitao , Zheng Sai-Li , He Yonghe , He Jun , Liao Wei-Ming , Xu Gang , Zeller Matthias , Xu Zhengtao
Published: February 2020

Metal-thiolate networks are topical electronic materials, but hard to crystallize: this one makes big single crystals, and boasts small band gap, stable radical organic linkers, and facile exfoliation into nanosheets.
Solution chemistry and phase solubility diagrams of CL-20/MTNP energetic cocrystals
Authors: Tang Luyang , Li Hongzhen , Tan Yanwei , Liu Tiansheng , Yang Zongwei
Published: February 2020

The solubility behavior and solution chemistry of CL-20/MTNP (2,4,6,8,10,12-hexanitro-hexaaza-isowurtzitane/1-methyl-3,4,5-trinitropyrazole) energetic cocrystals in organic solvents were first investigated to offer some important information on thermodynamics.
Tunable thickness and band structure of SnO sheets for improved photocatalytic activity
Authors: Zhang Rui , Kuang Jianlei , Lu Qipeng , Wang Qi , Sun Peng , Liu Wenxiu , Yin Shu , Cao Wenbin
Published: February 2020

SnO sheets with tunable thickness were prepared via a hydrothermal method by employing PEG as a structure-directing agent and the thickness of SnO exhibited a significant influence on the photocatalytic efficiency.
Iodide conversion to iodate in aqueous and solid aerosols exposed to ozone
Authors: Moreno Carolina , Baeza-Romero María-Teresa , Sanz Mikel , Gálvez Óscar , López Arza Vicente , Ianni James C. , Espíldora Eva
Published: February 2020

The aqueous and surface reactions of ozone with iodide in/on seawater have been recently found to be a strong atmospheric source of iodine. In this experimental study, we propose the direct products of this reaction in the aqueous and surface phases.
Deterministic control of surface mounted metal–organic framework growth orientation on metallic and insulating surfaces
Authors: Vello Tatiana Parra , Strauss Mathias , Costa Carlos Alberto Rodrigues , Corrêa Cátia Crispilho , Bof Bufon Carlos César
Published: February 2020

Surface-Mounted Metal–Organic Frameworks (SURMOFs) growth orientation in [100] or [111] can be deterministically controlled by the SAM chain length, regardless of the surface nature (metallic or insulating).
Polaronic structure of excess electrons and holes for a series of bulk iron oxides
Authors: Ahart Christian S. , Blumberger Jochen , Rosso Kevin M.
Published: February 2020

With the use of a gap-optimized hybrid functional and large supercells, it is found that while the electron hole polaron generally localises onto a single iron site, the electron polaron localises across two iron sites of the same spin layer.
Reaction kinetics of hydrogen addition reactions to methyl butenoate
Authors: Gao Yage , Li Xiaoyu , You Xiaoqing
Published: February 2020

We study the chemical kinetics of hydrogen addition reactions of unsaturated methyl esters, methyl 2-butenoate and methyl 3-butenoate, and compare the rate constants with those of hydrogen abstraction reactions by H atom.
Roll-to-roll printed high voltage supercapattery in lead-contaminated aqueous electrolyte
Authors: Getachew Teklewold , Mehretie Solomon , Yip Hin-Lap , Xia Ruidong , Admassie Shimelis
Published: February 2020

This work investigated the potential application of roll-to-roll printed PEDOT:PSS on an ITO/PET substrate using Pb2+ containing 0.1 M NaCl aqueous solution for a supercapattery.
Red-emitting neutral rhenium(i) complexes bearing a pyridyl pyridoannelated N-heterocyclic carbene
Authors: Bonfiglio Anna , Magra Kévin , Cebrián Cristina , Polo Federico , Gros Philippe C. , Mercandelli Pierluigi , Mauro Matteo
Published: February 2020

Two novel neutral rhenium(i) tricarbonyl complexes bearing a pyridoannelated N-heterocyclic carbene are synthetized and fully characterized, which display red photoluminescence arising from a triplet excited state with ligand centered character.
Highly stable inverted methylammonium lead tri-iodide perovskite solar cells achieved by surface re-crystallization
Authors: Back Hyungcheol , Kim Geunjin , Kim Heejoo , Nam Chang-Yong , Kim Jinhyun , Kim Yong Ryun , Kim Taejin , Park Byoungwook , Durrant James R. , Lee Kwanghee
Published: February 2020

A long-term operational stability over 1000 hours in the inverted type perovskite solar cells based on the MAPbI3 layer is demonstrated under ionic defect-free conditions.
In vitro bioaccessibility of minerals from microalgae-enriched cookies
Authors: Uribe-Wandurraga Zaida Natalia , Igual Marta , García-Segovia Purificación , Martínez-Monzó Javier
Published: February 2020

Microalgae can be used as an ingredient to enrich cookies with minerals. Cookies enriched with microalgae presented a higher content in minerals compared to control samples.
Aged citrus peel (chenpi) extract causes dynamic alteration of colonic microbiota in high-fat diet induced obese mice
Authors: Zhang Man , Zhu Jieyu , Zhang Xin , Zhao Deng-gao , Ma Yan-yan , Li Dongli , Ho Chi-Tang , Huang Qingrong
Published: February 2020

Aged citrus peels (chenpi) have been used as a dietary supplement for gastrointestinal health maintenance in China.
Biofabrication, structure and characterization of an amylopectin-based cyclic glucan
Authors: Chen Chen , Lu Keyu , Hu Xiuting , Liu Yao , Cui Steve W. , Miao Ming
Published: February 2020

A novel amylopectin-based cyclic architecture was fabricated, arising from microbial branching enzyme treated waxy rice starch.
Cleaner enzymatic production of biodiesel with easy separation procedures triggered by a biocompatible hydrophilic ionic liquid
Authors: Zhu Anlian , Feng Wanlu , Li Zhiyong , Cheng Shuang , Chen Qianhan , Fan Dongshuang , Guo Yuanyang , Li Lingjun , Wang Jianji
Published: February 2020

A biocompatible and hydrophilic ionic liquid was found to efficiently promote the enzymatic production of biodiesel with excellent yields from different oil resources.
Giant ultrafast optical nonlinearities of annealed Sb2Te3 layers
Authors: Moisset Charles , Verrone Richard-Nicolas , Bourgade Antoine , Zeweldi Gebrehiwot Tesfay , Minissale Marco , Gallais Laurent , Perrin-Pellegrino Carine , Akhouayri Hassan , Lumeau Julien , Natoli Jean-Yves , Iliopoulos Konstantinos
Published: February 2020

The optimization of a Sb2Te3 thin film structure in order to obtain giant ultrafast nonlinearities is presented.
Metal assisted chemical etching of silicon in the gas phase: a nanofabrication platform for X-ray optics
Authors: Romano Lucia , Kagias Matias , Vila-Comamala Joan , Jefimovs Konstantins , Tseng Li-Ting , Guzenko Vitaliy A. , Stampanoni Marco
Published: February 2020

Gas-MacEtch of Si with a Pt catalyst allows vertical etching nanostructures with an extreme aspect ratio up to 10 000 : 1.
Catalytic activity of a magnetic Fe2O3@CoFe2O4 nanocomposite in peroxymonosulfate activation for norfloxacin removal
Authors: Kohantorabi Mona , Hosseinifard Mojtaba , Kazemzadeh Asghar
Published: February 2020

In this study, Fe2O3 nanoparticles derived from a metal organic framework (MIL-88B) template were successfully decorated on CoFe2O4 flower-like nanostructures through a facile hydrothermal/calcination method.
Theoretical research on a coke-resistant catalyst for the partial oxidation of methane: Pt/Cu single-atom alloys
Authors: Meng Yuanyuan , Ding Chuanmin , Xue Yuyuan , Gao Xiaofeng , Zhang Kan , Wang Junwen , Li Zhe
Published: February 2020

Cu can prevent carbon deposition on a surface due to weak adsorption, but it exhibits a high energy barrier to C–H bond activation, which means that it is not practical.
BaTiO3nanoparticle-decorated hierarchical Ni nanowire assemblies for magnetoelectric applications
Authors: Revathy Ramany , Kaipamangalath Aswathi , Varma Manoj Raama , Surendran Kuzhichalil Peethambharan
Published: February 2020

One dimensional multiferroic systems with spin-charge coupling at room temperature are highly useful in future multifunctional devices.
Construction of efficient tung-oil-based thermal stabilizers bearing imide and epoxy groups for PVC
Authors: Wang Mei , Li Shouhai , Ding Haiyang , Xia Jianling , Li Mei
Published: February 2020

Tung-oil-derived imide epoxidized esters (GEABTMI) were successfully prepared and complexed with CaSt2/ZnSt2, which together displayed a good synergistic effect for stabilizing poly(vinyl chloride) (PVC).
Heterogeneous electrocatalytic reduction of CO2 promoted by secondary coordination sphere effects
Authors: Li Junnan , Zhang Yuxuan , Kornienko Nikolay
Published: February 2020

The incorporation of secondary coordination sphere effects to rationally modulate electrochemical CO2 reduction on heterogeneous catalysts is reviewed.
Chromogenic agents built around a multifunctional double-triazine framework for enzymatically triggered cross-linking under physiological conditions
Authors: Fujita Hikaru , Zhang Yunlong , Wu Zhiyuan , Lindsey Jonathan S.
Published: February 2020

A molecular architecture designed for bioconjugation and internal absorption ratiometry undergoes enzymatically triggered cleavage of glucosyl groups and subsequent oxidative dimerization in aqueous solution to yield indigoid-containing scaffolds.
A platinum–nickel bimetallic nanocluster ensemble-on-polyaniline nanofilm for enhanced electrocatalytic oxidation of dopamine
Authors: Yadav Anupam , Pandey Richa , Liao Ting-Wei , Zharinov Vyacheslav S. , Hu Kuo-Juei , Vernieres Jerome , Palmer Richard E. , Lievens Peter , Grandjean Didier , Shacham-Diamand Yosi
Published: February 2020

Designed fabrication of flexible metal alloy nanocluster–polyaniline hybrid materials for efficient (bio)electrochemical applications.
Near full light absorption and full charge collection in 1-micron thick quantum dot photodetector using intercalated graphene monolayer electrodes
Authors: Chen Wenjun , Ahn Seungbae , Balingit Marquez , Wang Jiaying , Lockett Malcolm , Vazquez-Mena Oscar
Published: February 2020

High charge collection efficiency in Vis and NIR using intercalated QD/Gr systems.
Thermal robustness of magnetic tunnel junctions with perpendicular shape anisotropy
Authors: Lequeux S. , Perrissin N. , Grégoire G. , Tillie L. , Chavent A. , Strelkov N. , Vila L. , Buda-Prejbeanu L. D. , Auffret S. , Sousa R. C. , Prejbeanu I. L. , Di Russo E. , Gautier E. , Conlan A. P. , Cooper D. , Dieny B.
Published: February 2020

Perpendicular Shape Anisotropy based storage layer offers a bulk anisotropy much more robust against thermal fluctuations than the interfacial anisotropy, allowing to reduce the temperature dependence of the coercivity of sub-20 nm MTJ cells.
Bridge engineering in photocatalysis and photoelectrocatalysis
Authors: Zhong Shuxian , Xi Yamin , Chen Qin , Chen Jianrong , Bai Song
Published: February 2020

Bridge engineering in mediating the interfacial charge transfer between components/particles in photocatalytic and photoelectrochemical systems is reviewed.
Polyoxometalate-based composite materials in electrochemistry: state-of-the-art progress and future outlook
Authors: Wang Dan , Liu Lulu , Jiang Jun , Chen Lijuan , Zhao Junwei
Published: February 2020

This review summarizes some representative advances in PCMs with electrochemical applications in the past ten years, expecting to provide some useful guidance for future research.
Introducing sequential aza-amino acids units induces repeated β-turns and helical conformations in peptides
Authors: Tonali Nicolo , Correia Isabelle , Lesma Jacopo , Bernadat Guillaume , Ongeri Sandrine , Lequin Olivier
Published: February 2020

A major current issue in medicinal chemistry is the design of small peptide analogues resistant to proteolysis and able to adopt preferential conformations, while preserving the selectivity and efficiency of natural peptides.
Nitro-graphene oxide in iridium oxide hybrids: electrochemical modulation of N-graphene redox states and charge capacities
Authors: Pérez E. , Carretero N. M. , Sandoval S. , Fuertes A. , Tobias G. , Casañ-Pastor N.
Published: February 2020

Electrochemical modulation of N-graphene oxide in IrOx hybrids results in an oxidizing range of graphenes and large charge capacities.
Near-infrared electron acceptors with fused nonacyclic molecular backbones for nonfullerene organic solar cells
Authors: Zhang Jianquan , Li Yunke , Peng Zhengxing , Bai Fujin , Ma Lik-Kuen , Ade Harald , Li Zhengke , Yan He
Published: February 2020

Two strong electron-donating moieties were fused into the molecular backbone of small molecular acceptors showing dramatically extended absorption beyond 900 nm.
Aqueous colloidal systems of bovine serum albumin and functionalized surface active ionic liquids for material transport
Authors: Singh Gagandeep , Kaur Manvir , Aswal Vinod Kumar , Kang Tejwant Singh
Published: February 2020

Physicochemical and computational investigation of complexation between BSA and SAILs with application in material transport.
Biomass-derived three-dimensional carbon framework for a flexible fibrous supercapacitor and its application as a wearable smart textile
Authors: Hsiao Chunghsuan , Lee Chiyoung , Tai Nyanhwa
Published: February 2020

High electrochemical performance and mechanical reliability are two important properties of the flexible fibrous supercapacitors (FFSCs) used in portable and wearable electronics.
Molecular flattening effect to enhance the conductivity of fused porphyrin tape thin films
Authors: Bengasi Giuseppe , Desport Jessica S. , Baba Kamal , Cosas Fernandes João P. , De Castro Olivier , Heinze Katja , Boscher Nicolas D.
Published: February 2020

This work reports the strong correlation between the conductivity of fused porphyrins thin films and the porphyrin substituents.
Effect of tannin addition on chromatic characteristics, sensory qualities and antioxidant activities of red wines
Authors: Li Lingxi , Li Zhe , Wei Zongmin , Yu Weichao , Cui Yan
Published: February 2020

The effect of tannin addition on the wine overall quality were investigated and an ideal tannin addition was recommended for wine quality improving.
Chemical fingerprinting and quantitative monitoring of the doping drugs bambuterol and terbutaline in human urine samples using ATR-FTIR coupled with a PLSR chemometric tool
Authors: Algethami Faisal K. , Eid Sherif M. , Kelani Khadiga M. , Elghobashy Mohamed R. , Abd El-Rahman Mohamed K.
Published: February 2020

ATR-FTIR spectroscopy coupled with chemometric tools could be a suitable alternative to the traditional techniques for quantification of the performance enhancing drugs such as bambuterol and terbutaline in urine samples in and out of competition.
Shape-stabilized composite phase change film with good reversible thermochromic properties fabricated via phase inversion-assisted impregnation
Authors: Wang Yuhan , Feng Nianrong , Kang Zhe , Wu Dongfu , Hu Dongying
Published: February 2020

In this study, the composite phase-change cellulose-based film was prepared by phase inversion-assisted impregnation.
N-Substitution of acridone with electron-donating groups: crystal packing, intramolecular charge transfer and tuneable aggregation induced emission
Authors: Liu Renfei , Zhu Guanxing , Zhang Gang
Published: February 2020

Triphenylamine functionalized acridone leads to a donor–acceptor system with intramolecular charge transfer process and tuneable aggregation induced enhanced emission.
Probing the electronic and mechanistic roles of the μ4-sulfur atom in a synthetic CuZ model system
Authors: Rathnayaka Suresh C. , Islam Shahidul M. , DiMucci Ida M. , MacMillan Samantha N. , Lancaster Kyle M. , Mankad Neal P.
Published: February 2020

Experimental data and computational modeling indicates an active role for the bridging sulfide ligand in a synthetic CuZ model.
Electron-enriched thione enables strong Pb–S interaction for stabilizing high quality CsPbI3 perovskite films with low-temperature processing
Authors: Xu Xiaojia , Zhang Hao , Li Erpeng , Ru Pengbin , Chen Han , Chen Zhenhua , Wu Yongzhen , Tian He , Zhu Wei-Hong
Published: February 2020

A neutral molecular additive of 4(1H)-pyridinethione (4-PT) is used for growing high quality black-phase CsPbI3 thin films at low temperatures.
Charge transfer dynamics in a singlet fission organic molecule and organometal perovskite bilayer structure
Authors: Guo Deqiang , Ma Lin , Zhou Zilin , Lin Dabin , Wang Cheng , Zhao Xin , Zhang Fangteng , Zhang Jiahua , Nie Zhaogang
Published: February 2020

Ultrafast electron transfer is demonstrated from correlated triplet pairs generated by singlet fission in TIPS-pentacene to the CH3NH3PbI3 perovskite.
Identifying the anionic redox activity in cation-disordered Li1.25Nb0.25Fe0.50O2/C oxide cathodes for Li-ion batteries
Authors: Luo Mingzeng , Zheng Shiyao , Wu Jue , Zhou Ke , Zuo Wenhua , Feng Min , He Huajin , Liu Rui , Zhu Jianping , Zhao Gang , Chen Shijian , Yang Wanli , Peng Zhangquan , Wu Qihui , Yang Yong
Published: February 2020

Reversible lattice oxygen reaction, and irreversible oxygen release are clarified in high capacity cation-disordered Li1.25Nb0.25Fe0.50O2/C cathode for Li-ion batteries.
Stabilization of Pt nanoparticles at the Ta2O5–TaC binary junction: an effective strategy to achieve high durability for oxygen reduction
Authors: Gao Wenbin , Liu Tongtong , Zhang Zhengping , Dou Meiling , Wang Feng
Published: February 2020

A robust Pt-based ORR electrocatalyst was synthesized through strongly stabilizing Pt nanoparticles at the Ta2O5–TaC binary junction.
Enhanced surface binding energy regulates uniform potassium deposition for stable potassium metal anodes
Authors: Zhao Xinxin , Chen Fengjiao , Liu Junqing , Cheng Mingren , Su Hai , Liu Jianbo , Xu Yunhua
Published: February 2020

A SnO2-coated carbon fiber mat is fabricated and used to guide uniform K nucleation/deposition for dendrite free K metal anodes.
Tungsten oxysulfide nanosheets for highly sensitive and selective NH3sensing
Authors: Zheng Yanan , Sun Lan , Liu Weiwei , Wang Chen , Dai Zhengfei , Ma Fei
Published: February 2020

Ultrathin tungsten oxysulfide (WS2|O) nanosheets are fabricated through a one-step hydrothermal process and employed for highly efficient chemiresistive NH3sensing.
Nitrogen-mediated aligned growth of hexagonal BN films for reliable high-performance InSe transistors
Authors: Chng Soon Siang , Zhu Minmin , Wu Jing , Wang Xizu , Ng Zhi Kai , Zhang Keke , Liu Chongyang , Shakerzadeh Maziar , Tsang Siuhon , Teo Edwin Hang Tong
Published: February 2020

Orientation controlled hexagonal boron nitride (h-BN) films exhibit excellent mechanical and thermal properties, making them attractive for diverse applications.
Optimization of confined direct analysis in real time mass spectrometry (DART-MS)
Authors: Sisco Edward , Staymates Matthew E. , Forbes Thomas P.
Published: February 2020

Developing an understanding of confined DART-MS analysis.
Rapid and accurate detection of Escherichia coli O157:H7 in beef using microfluidic wax-printed paper-based ELISA
Authors: Zhao Yanan , Zeng Dexin , Yan Chao , Chen Wei , Ren Jianluan , Jiang Yuan , Jiang Luyan , Xue Feng , Ji Dejun , Tang Fang , Zhou Mingqiang , Dai Jianjun
Published: February 2020

Escherichia coli O157:H7 is a severe foodborne pathogen. Paper-based ELISA can rapidly and accurately detect E.coli O157:H7 in beef. The method has good sensitivity, specificity and repeatability. It is suitable for point-of-care testing and offers new ideas for the detection of other foodborne pathogens.
Synthesis, X-ray characterization and regium bonding interactions of a trichlorido(1-hexylcytosine)gold(iii) complex
Authors: Terrón Angel , Buils Jordi , Mooibroek Tiddo J. , Barceló-Oliver Miquel , García-Raso Angel , Fiol Juan J. , Frontera Antonio
Published: February 2020

We report the first gold(iii) complex with a cytosine derivative since 35 years. In the crystal structure, the complex stacks by reciprocal regium-bonding interactions. These interactions appear to be common in the Cambridge structure database.
Binding affinity and dissociation pathway predictions for a series of USP7 inhibitors with pyrimidinone scaffold by multiple computational methods
Authors: Wang Zhe , Wang Xuwen , Kang Yu , Zhong Haiyang , Shen Chao , Yao Xiaojun , Cao Dongsheng , Hou Tingjun
Published: February 2020

Ubiquitin specific protease 7 (USP7) has attracted increasing attention because of its multifaceted roles in different tumor types.
Correction: Conformation of bis-nitroxide polarizing agents by multi-frequency EPR spectroscopy
Authors: Soetbeer Janne , Gast Peter , Walish Joseph J. , Zhao Yanchuan , George Christy , Yang Chen , Swager Timothy M. , Griffin Robert G. , Mathies Guinevere
Published: February 2020

Correction for ‘Conformation of bis-nitroxide polarizing agents by multi-frequency EPR spectroscopy’ by Janne Soetbeer et al., Phys. Chem. Chem. Phys., 2018, 20, 25506–25517.
Selective and efficient removal of perrhenate by an imidazolium based hexapodal receptor in water medium
Authors: Ghosh Rajib , Ghosh Tamal Kanti , Ghosh Pradyut
Published: February 2020

This work reports a new cationic imidazolium based hexapodal receptor, [L.6Br], for selective and efficient removal of perrhenate (ReO4−) as [L.6ReO4] from 100% aqueous medium via extraction through precipitation.
Designing multiple bioactives loaded emulsions for the formulations for diets of elderly
Authors: Keršienė Milda , Jasutienė Ina , Eisinaitė Viktorija , Venskutonis Petras Rimantas , Leskauskaitė Daiva
Published: February 2020

In this study, a stable double emulsion loaded with essential bioactives for the elderly was prepared using a two-step mechanical emulsification process.
Dynamic screening and printing of single cells using a microfluidic chip with dual microvalves
Authors: Chen Chang , Xu Dong , Bai Siwei , Yu Zhihang , Zhu Yonggang , Xing Xiao , Chen Huaying
Published: February 2020

Inoculation of single cells into separate chambers is one of the key requirements in single-cell analysis. Here we report a three-layer microfluidic platform integrated with dual-pneumatic valves for dynamic screening and printing of single cells.
Integration of fluorescence/photoacoustic imaging and targeted chemo/photothermal therapy with Ag2Se@BSA-RGD nanodots
Authors: Yin Xiuhui , Li Xianglong , Zhu Chunling , Lin Xucong , Xie Zenghong
Published: February 2020

By a facile protein-based biomineralization method, Ag2Se@BSA-RGD QDs with ultrasmall sizes were obtained and exhibited a high fluorescence quantum yield, strong photoacoustic signals and promising photothermal conversion efficiency.
Highly stable Na: CsPb(Br,I)3@Al2O3 nanocomposites prepared by a pre-protection strategy
Authors: Ji Yongqiang , Wang Minqiang , Yang Zhi , Qiu Hengwei , Ji Shangdong , Dou Jinjuan , Gaponenko Nikolai V.
Published: February 2020

Among the leading energy materials, metal tri-halide perovskite quantum dots (PQDs) with outstanding optoelectronic properties are at the forefront of current research.
The pKavalues ofN-aryl imidazolinium salts, their higher homologues, and formamidinium salts in dimethyl sulfoxide
Authors: Konstandaras Nicholas , Dunn Michelle H. , Luis Ena T. , Cole Marcus L. , Harper Jason B.
Published: February 2020

The effects of substitution, ring size and cyclisation on the pKavalues of imidazolinium salts, higher homologues and formamidinium salts in DMSO are quantified, considering structural and electronic motifs along with crystallographic analyses.
Synthesis of 4-chalcogenyl pyrazoles via electrophilic chalcogenation/cyclization of α,β-alkynic hydrazones
Authors: Yu Xinzhang , Shang Yu-Zhu , Cheng Yu-Fei , Tian Jun , Niu Yulan , Gao Wen-Chao
Published: February 2020

4-Chalcogenyl pyrazoles, including the 4-sulfenyl celecixib derivative, are accessed through cyclization of α,β-alkynic hydrazones induced by S-electrophiles prepared in advance or generated in situ.
Photo-mediated synthesis of halogenated spiro[4,5]trienones of N-aryl alkynamides with PhI(OCOCF3)2 and KBr/KCl
Authors: Liu Tong , Li Yaming , Jiang Linlin , Wang Jiaao , Jin Kun , Zhang Rong , Duan Chunying
Published: February 2020

A novel and convenient photo-mediated halogenated spirocyclization of N-(p-methoxyaryl)propiolamides has been developed.
Aggregation-induced emission polymers for high performance PLEDs with low efficiency roll-off
Authors: Gu Jiabao , Xu Zeng , Ma Dongge , Qin Anjun , Tang Ben Zhong
Published: February 2020

AIE polymers pTPE-DPA-Cz and pTPE-DPA-Flu are synthesized and used as emitting layers in doped and non-doped polymeric LEDs through a solution process, and show maximum EQE of 3.26% in the doped PLEDs and CE of 3.69 cd A−1 for the non-doped PLEDs and low efficiency roll-off.
The effect of n–π* electronic transitions on the N2 photofixation ability of carbon self-doped honeycomb-like g-C3N4 prepared via microwave treatment
Authors: Li Xuelei , Bai Jinfeng , Li Jiaqi , Li Chao , Zhong Xiangyun , Deng Shuping
Published: February 2020

Light harvesting is an important part of the photocatalysis process.
Synthesis of the microspherical structure of ternary SiOx@SnO2@C by a hydrothermal method as the anode for high-performance lithium-ion batteries
Authors: Gu Zhiqiang , Li Wenli , Chen Yuxi , Xia Xiaohong , Liu Hongbo
Published: February 2020

A ternary microspherical SiOx@SnO2@C composite with appropriate electrochemical performance was prepared by a facile hydrothermal method.
An air CO2 capture system based on the passive carbonation of large Ca(OH)2 structures
Authors: Abanades J. Carlos , Criado Yolanda A. , Fernández José Ramón
Published: February 2020

Passive direct air capture by the carbonation of large scale Ca(OH)2 porous structures that can be regenerated by means of well-tried technologies, while producing a pure CO2 stream ready for storage.
How an organogelator can gelate water: gelation transfer from oil to water induced by a nanoemulsion
Authors: Nouri Vivien , Pontes De Siqueira Moura Marigilson , Payre Bruno , De Almeida Olivier , Déjugnat Christophe , Franceschi Sophie , Perez Emile
Published: February 2020

A hydrogel can be formed by an organogelator in the presence of a nanoemulsion.
Transparent conductive elastomers with excellent autonomous self-healing capability in harsh organic solvent environments
Authors: Li Ren'ai , Chen Guangxue , Fan Ting , Zhang Kaili , He Minghui
Published: February 2020

A new type of transparent conductive elastomer with excellent autonomous self-healing capability in harsh organic solvent environments is reported.
Suppressing the dynamic precipitation and lowering the thermal conductivity for stable and high thermoelectric performance in BaCu2Te2 based materials
Authors: Guo Kai , Lin Jianwei , Li Yang , Zhu Yifan , Li Xin , Yang Xinxin , Xing Juanjuan , Yang Jiong , Luo Jun , Zhao Jing-Tai
Published: February 2020

Cu-rich nano-precipitation in BaCu2Te2 sample realize the balance of precipitation and dissolution, and thus optimizing the hole concentration approaching to the optimal one, as well as leading to the stable degenerate semiconducting behaviors.
Bifunctional nickel ferrite-decorated carbon nanotube arrays as free-standing air electrode for rechargeable Zn–air batteries
Authors: Yan Ya , Xu Yangyang , Zhao Bin , Xu Yong , Gao Yan , Chen Guangda , Wang Weibo , Xia Bao Yu
Published: February 2020

A free-standing air electrode is constructed by direct growth of NiFeOxnanoparticles on vertically aligned carbon nanotube arrays for high-performance rechargeable Zn–air batteries.
MiR-203a-3p regulates TGF-β1-induced epithelial–mesenchymal transition (EMT) in asthma by regulating Smad3 pathway through SIX1
Authors: Fan Qi , Jian Yu
Published: February 2020

Asthma is a common chronic airway disease with increasing prevalence. MicroRNAs act as vital regulators in cell progressions and have been identified to play crucial roles in asthma. The objective of the present study is to clarify the molecular mechanism of miR-203a-3p in the development of asthma. The expression of miR-203a-3p and Sine oculis homeobox homolog 1 (SIX1) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein levels of SIX1, fibronectin, E-cadherin, vimentin, phosphorylated-drosophila mothers against decapentaplegic 3 (p-Smad3) and Smad3 were measured by Western blot. The interaction between miR-203a-3p and SIX1 was confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. MiR-203a-3p was down-regulated and SIX1 was up-regulated in asthma serums, respectively. Transforming growth factor-β1 (TGF-β1) treatment induced the reduction of miR-203a-3p and the enhancement of SIX1 in BEAS-2B and 16HBE cells in a time-dependent manner. Subsequently, functional experiments showed the promotion of epithelial–mesenchymal transition (EMT) induced by TGF-β1 treatment could be reversed by miR-203a-3p re-expression or SIX1 deletion in BEAS-2B and 16HBE cells. SIX1 was identified as a target of miR-203a-3p and negatively regulated by miR-203a-3p. Then rescue assay indicated that overexpressed miR-203a-3p ameliorated TGF-β1 induced EMT by regulating SIX1 in BEAS-2B and 16HBE cells. Moreover, miR-203a-3p/SIX1 axis regulated TGF-β1 mediated EMT process in bronchial epithelial cells through phosphorylating Smad3. These results demonstrated that MiR-203a-3p modulated TGF-β1-induced EMT in asthma by regulating Smad3 pathway through targeting SIX1.
ZFPM2-AS1 facilitates cell growth in esophageal squamous cell carcinoma via up-regulating TRAF4
Authors: Sun Gaozhong , Wu Changhao
Published: February 2020

Emerging evidence has confirmed that long noncoding RNAs (lncRNAs) are strongly involved in tumor initiation and development. LncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) has been identified as a tumor facilitator in some cancers; nevertheless, its functional significance and regulatory mechanism remain greatly unclear in esophageal squamous cell carcinoma (ESCC). Here, we detected ZFPM2-AS1 expression in ESCC cell lines using qRT-PCR. ZFPM2-AS1 knockdown models were established for investigating the biological function of ZFPM2-AS1 in ESCC cells. The association between miR-3612 and ZFPM2-AS1 or TRAF4 was assessed by RNA pull-down and luciferase reporter assays. The present study indicated that ZFPM2-AS1 was significantly up-regulated in ESCC cells. Functional assays manifested that ZFPM2-AS1 knockdown restrained cell proliferation, migration and invasion, and facilitated cell apoptosis in ESCC. Mechanistically, ZFPM2-AS1 promoted ESCC cell growth and up-regulated TRAF4 to trigger NF-κB pathway by sequestering miR-3612. Besides, miR-3612 was confirmed to be a tumor inhibitor in ESCC. Through restoration experiments, we observed that TRAF4 overexpression could recover the suppressive effect of ZFPM2-AS1 on ESCC cell growth. Collectively, all the results suggested that ZFPM2-AS1 was an oncogene in ESCC cell growth by up-regulating TRAF4 and activating NF-κB pathway.
ER-Golgi membrane contact sites
Authors: Venditti Rossella , Masone Maria Chiara , De Matteis Maria Antonietta
Published: February 2020

Membrane contact sites (MCSs) are sites where the membranes of two different organelles come into close apposition (10–30 nm). Different classes of proteins populate MCSs including factors that act as tethers between the two membranes, proteins that use the MCSs for their function (mainly lipid or ion exchange), and regulatory proteins and enzymes that can act in trans across the MCSs. The ER-Golgi MCSs were visualized by electron microscopists early in the sixties but have remained elusive for decades due to a lack of suitable methodological approaches. Here we report recent progress in the study of this class of MCSs that has led to the identification of their main morphological features and of some of their components and roles. Among these, lipid transfer proteins and lipid exchange have been the most studied and understood so far. However, many unknowns remain regarding their regulation and their role in controlling key TGN functions such as sorting and trafficking as well as their relevance in physiological and pathological conditions.
Reading patterns of proteome damage by glycation, oxidation and nitration: quantitation by stable isotopic dilution analysis LC-MS/MS
Authors: Rabbani Naila , Thornalley Paul J.
Published: February 2020

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides a high sensitivity, high specificity multiplexed method for concurrent detection of adducts formed by protein glycation, oxidation and nitration, also called AGEomics. Combined with stable isotopic dilution analysis, it provides for robust quantitation of protein glycation, oxidation and nitration adduct analytes. It is the reference method for such measurements. LC-MS/MS has been used to measure glycated, oxidized and nitrated amino acids – also called glycation, oxidation and nitration free adducts, with a concurrent quantitation of the amino acid metabolome in physiological fluids. Similar adduct residues in proteins may be quantitated with prior exhaustive enzymatic hydrolysis. It has also been applied to quantitation of other post-translation modifications, such as citrullination and formation of Nε-(γ-glutamyl)lysine crosslink by transglutaminases. Application to cellular and extracellular proteins gives estimates of the steady-state levels of protein modification by glycation, oxidation and nitration, and measurement of the accumulation of glycation, oxidation and nitration adducts in cell culture medium and urinary excretion gives an indication of flux of adduct formation. Measurement of glycation, oxidation and nitration free adducts in plasma and urine provides for estimates of renal clearance of free adducts. Diagnostic potential in clinical studies has been enhanced by the combination of estimates of multiple adducts in optimized diagnostic algorithms by machine learning. Recent applications have been in early-stage detection of metabolic, vascular and renal disease, and arthritis, metabolic control and risk of developing vascular complication in diabetes, and a blood test for autism.
Strict proof for the state transition matrix of linear discrete time‐varying stochastic systems
Authors: Zhang Tianliang , Weihai Zhang , Deng Feiqi
Published: February 2020

This note presents a strict proof for the state transition matrix of linear discrete time‐varying stochastic systems, which corrects the errors of the previous references.
Power sharing strategy for multi‐source electrical auxiliary power unit with bi‐directional interaction capability
Authors: Tashakor Nima , Arabsalmanabadi Bita , Iraji Farzad , Al‐Haddad Kamal
Published: February 2020

This study presents a hierarchical control strategy for an auxiliary power unit (APU) for aircraft to coordinate multiple power sources and control developed power electronic interfaces. The study benefits from the presence of a hybrid energy system in paralleled structure to the main generator as the complementary system. The employed structure enhances power quality and improves the voltage profile of the high‐voltage DC bus. Furthermore, the developed bi‐directional topology provides the possibility of interaction with the grid. Considering the APU features in an aircraft, a hierarchical control strategy with different levels of control, timescale, dynamic response, and significance are developed. The developed controller consists of a power management algorithm in the higher level, and local voltage and current controllers in the lower one. The algorithm aims to maximise the PV sub‐system utilisation, overcome voltage fluctuations, increase power density, reduce operation costs, and increase system availability while allowing further development to larger systems. Simulation and experimental results confirm the robustness of the algorithm. The result shows that the proposed power sharing strategy optimises the system utilisation while achieving a high‐quality voltage profile under severe fluctuations. Moreover, the stress on the battery pack is reduced to improve the life cycle and reduce operation costs.
Enhanced momentum LMS‐based control technique for grid‐tied solar system
Authors: Singh Sunaina , Kewat Seema , Singh Bhim , Panigrahi Bijaya K.
Published: February 2020

This study deals with a single‐stage photovoltaic (PV) grid‐tied system along with enhanced momentum least mean square (EMLMS) control algorithm, which extracts the fundamental components from the non‐linear load currents. Three‐phase voltage‐source converter with the EMLMS technique, feeds the solar PV power into the grid. Moreover, it is used to reduce the harmonics, load unbalancing and it compensates the reactive power to achieve the unity power factor of the grid currents. Moreover, this control provides the good dynamic response and fast convergence speed with less steady‐state error. The main objective of this control algorithm is to provide the sinusoidal and balanced grid currents under steady‐state and dynamic conditions. Test results of EMLMS technique are validated on a developed laboratory prototype.
Avoiding overvoltage problems in three‐phase distributed‐generation systems during unbalanced voltage sags
Authors: Castilla Miguel , Camacho Antonio , Miret Jaume , Guzmán Ramón , García de Vicuña Luis
Published: February 2020

During voltage sags, distributed generation systems must fulfil specific grid‐code requirements for reactive current injection. This ancillary service can produce overvoltage problems in networks operating in unbalanced conditions when the amplitude of one of the phase voltages is higher than the others and a balanced reactive current is injected through large grid impedance. This study proposes a control scheme to avoid these overvoltage problems, thus reducing the risk of cascade disconnection that this incident may produce. The derivation of the control scheme starts from the flexible oscillating‐power control, introduces the necessary modifications so that this control meets the grid‐code requirements for current injection and combines it with a slope voltage control to achieve a good voltage regulation. A theoretical analysis is included to determine the expressions that quantify the voltage support characteristics of the proposal. Finally, selected experimental results are reported to validate the characteristics of the proposed control.