bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Serum Zinc Level and Cutaneous Viral Warts: A Case Control Study
Authors: Ranjit Annu , Rajbhandari Sudharshan Lal , Gautam Narayan , Poudyal Yogesh
Published: May 2019

Introduction: Cutaneous viral warts are one of the common skin disorders in general population which can affect any age group and any gender in any country and pose a significant health problem. A possible association with zinc has been suggested in previous studies. Zinc is known to be required for efficient functioning of immune system.

Objective: To find out the association between serum zinc level and cutaneous viral warts. 

Materials and methods: In this case-control study, total of hundred patients were enrolled. Among them 50 (males – 27, females – 23) with cutaneous viral warts were taken as cases and 50 (males – 25, females – 25) healthy individuals were taken as controls after matching the age and sex. The patients were selected from Dermatology outpatient Department of Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal. The serum zinc level was measured using spectrophotometry principle.

Results: The mean serum zinc level in the cases and controls were 80.50±37.24 mg/dl and 104.31±25.31 mg/dl respectively. Significant difference in serum zinc level was observed between cases and controls (p=0.0001). There was a strong association between low serum zinc level and cutaneous viral warts (OR=7.37; 95% CI=1.98 – 27.31; p=0.0028).

Conclusion: Serum zinc level in patients with cutaneous viral warts was significantly low as compared to the healthy controls.
Sporadic Progressive Symmetric Erythrokeratoderma: Classical Presentation of a rare Condition
Authors: Agarwal Kompal , Agrawal Sudha , Pradhan Anju
Published: May 2019

Progressive symmetrical erythrokeratodermia (PSEK) is a rare autosomal dominant genodermatosis presenting in infancy or early childhood. An 11-year-old male presented with a history of pruritic, erythematous, scaly, hyperkeratotic plaques first noted at 5 years of age, with no history of similar lesions in the family. Cutaneous examination revealed multiple, irregularly shaped, erythematous plaques with fine, shiny white, adherent scaling distributed symmetrically over the face, trunk, inguinal area, bilateral axillae and extensor surfaces of limbs. Palmoplantar keratoderma was present with thickened, yellowish discolored nails. No systemic abnormality was found. The histopathological findings were consistent with PSEK. The case is being reported to increase the awareness about this rare disease.
Analisis Faktor-Faktor Yang Mempengaruhi Kepuasan Pelanggan Fixpay Menggunakan SEM Dengan PLS
Authors: Kuntoro Antonius Yadi , Hasan Moh. Arie , Saputra Dedi Dwi , Riana Dwiza
Published: May 2019

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas pelayanan, nilai pelanggan, dan kepercayaan terhadap kepuasan pelanggan pada Fixpay. Fixpay adalah sebuah platform Mobile Payment yang dapat melakukan beragam jenis pembayaran dan pembelian secara online dari smartphone..Penelitian ini menggunakan pendekatan kuantitatif dengan metode asosiatif. Data yang digunakan menggunakan data primer berupa kuesioner yang diperoleh melalui google form. Pengambilan sampel menggunakan teknik non random sampling sehingga diperoleh sampel penelitian sebanyak 100 responden. Hasil penelitian menunjukkan bahwa kualitas pelayanan, nilai pelanggan, dan kepercayaan berpengaruh signifikan terhadap kepuasan pelanggan Fixpay baik secara parsial maupun simultan. Disarankan kepada pihak perusahaan untuk terus meningkatkan kepuasan pelanggan, seperti dengan membuat mudah aplikasi Fixpay untuk dioperasionalisasikan, mudah mengakses aplikasi, dan meningkatkan nilai kegunaan dari aplikasi Fixpay. Pengolahan data dalam penelitian ini menggunakan Structural Equation Modeling (SEM) dengan Partial Least Square (PLS).
Piezo-spectroscopic and tribological characterization of diffusion bonded oxide laminate composite ceramics
Authors: Hosseinabadi Navid
Published: May 2019

This study is focused on mechanical and tribological performance with phase and crystal structure studies of diffusion bonded dense α-alumina laminates with chemically activated Al–Sr mixed hydride (SrH2/Sr2AlH7) nano-particles as the interlayer by developing a controlled interlayer for preparing oxide laminate composites with high fracture toughness and enhanced wear resistance. Shear bond strength and four-point bending tests indicated a maximum strength of 174 and 189 MPa for hot pressed alumina/Sr2AlH7, with a transgranular fracture mechanism under shear stress. The difference in the coefficient of thermal expansion between the composites layers resulted in the development of residual stresses in alumina and interlayer. The magnitude and the distribution of these micro and macro residual stresses were assessed by the piezo-spectroscopic technique. The effects of residual stress on fracture toughness and the friction coefficient of laminates were studied.
Ensino de Tatos, Respostas de Ouvinte e Efeitos sobre Intraverbais em Autistas
Authors: De Matos Daniel Carvalho , De Araújo Creuziana Xavier , Da Silva Katiane Reis
Published: May 2019

Efeitos de metodologias de intervenção em Análise do Comportamento são investigados sobre a aprendizagemde intraverbais, que costumam ser deficientes em crianças autistas. O objetivo desta pesquisa foi medir efeitosdo ensino de repertórios de tato e ouvinte, organizado em dois diferentes pacotes de intervenções para duasduplas de crianças autistas, sobre a emergência de intraverbais de relatar membros de categorias. Para duascrianças da condição tato, foi implementado o ensino de tatos simples, tatos simples com feedback instrutivoe tatos de categorias; para duas crianças da condição ouvinte, ensino de respostas de ouvinte simples, respostascom feedback instrutivo e identificação de categorias como ouvinte. Não foi demonstrado qualquer efeito deemergência de intraverbais, e seu ensino direto demandou o uso de muitas pistas (tato e ecoico), sendo queimplicou evolução com variabilidade para um participante e dependência do tato como pista. São discutidaspossibilidades de adaptações metodológicas para pesquisas futuras.
Contribuições da Prática de mindfulness para o desenvolvimento de habilidades terapêuticas
Authors: Cardoso Bruno Luiz Avelino , Demarzo Marcelo
Published: May 2019

No contexto clínico, comportamentos do terapeuta e a relação que ele estabelece com o cliente não apenas são relevantes, mas podem facilitar ou prejudicar o desenvolvimento do processo terapêutico. Pretendeu-se, a partir de uma revisão narrativa, apresentar algumas contribuições da prática de mindfulness para odesenvolvimento de habilidades terapêuticas. Para isso, discutiu-se, a partir dos fundamentos conceituais domindfulness e da prática clínica em Psicologia, como o exercício da atenção plena pode auxiliar nodesenvolvimento de habilidades terapêuticas. Desse modo foi utilizado o modelo dos cinco elementosproposto por Baer, Smith, Hopkins, Krietemeyer e Toney (2006) e Zarbock, Lynch, Ammann e Ringer (2015),bem como as considerações de Fulton (2016) quanto às habilidades desenvolvidas por meio da atenção plena.Destacou-se que a aprendizagem de atitudes próprias da prática da atenção plena pode colaborar para oatendimento clínico a partir do fortalecimento do vínculo terapêutico entre cliente e profissional, bem comofavorece um ambiente de audiência não punitiva para os eventos que ocorrem durante a terapia, atitudeconhecida como aceitação ou “olhar do principiante”.
Aspectos históricos da Terapia Analítico-comportamental a partir da contribuição de Skinner e Ferster
Authors: Cassas Fernando Albregard , De Luna Sergio Vasconcelos
Published: May 2019

O presente artigo retomou dois conjuntos de trabalhos que discutiram a terapia durante a segunda metade doséculo XX com o objetivo de demonstrar que alguns princípios fundamentais da prática do analista docomportamento não foram abandonadas e estão presentes na prática clínica atual, principalmente na brasileira.O primeiro conjunto refere-se a uma revisão das principais análises de B. F. Skinner sobre terapia ao longo desua obra; o segundo descreve os dois trabalhos de C. B. Ferster sobre a atuação em consultório. Os temasdiscutidos pelos dois autores constituem elementos críticos para algumas práticas terapêuticas analíticocomportamentais(TAC), em especial a terapia analítico-comportamental brasileira. Alguns dos temas ganhamimportância particular por sua atualidade, enquanto outros se constituíram como ponto de partida paradesenvolvimentos atuais. Foi apresentado, também, um breve histórico da terapia comportamental como elafoi descrita pela literatura estrangeira e como essa análise se relaciona com a história brasileira. A retomadados trabalhos permitiu demonstrar que alguns elementos ainda são presentes em propostas terapêuticas, emespecial a TAC, como construir uma explicação (em termos de contingências) para o comportamento docliente, ensiná-lo a observar o próprio comportamento, intervenção direta durante uma sessão, entre outras.Foi possível, assim, demonstrar que alguns elementos das bases da Análise do Comportamento ainda sãopresentes em propostas terapêuticas, em especial na TAC brasileira.
Kritik Hadis Zakaria Ouzon
Authors: Zamawi Baharudin Zamawi
Published: May 2019

Hadis has strength authority as Islamic law. It’s function is the explanatory of the Qur’an and otherwise. The significance of the hadis requires its protecting and conserving by codification. Muslim scholars had collected thousands of hadis in many books that well-known as The Nine Primary Book of Hadis (Kutu>b al-Tis’ah). One of them, S}ah}i>h} al-Bukha>ri, was claimed as the most authentic book, because it is contain the only authentic (s}ah}i>h}) hadis. Moreover S}ah}i>h} al-Bukha>ri had important position as the source of Islamic law right below Quran. But the popularity of S}ah}i>h} al-Bukha>ri was underestimated by Zakaria Ouzon, the scholar who criticized works of many muslim scholars, one of them is S}ah}i>h} al-Bukha>ri. He claimed that hadis collected in S}ah}i>h} al-Bukha>ri was authentic (s}ah}i>h}) and could be used as h}ujjah. He argued that some hadis in S}ah}i>h} al-Bukha>ri must be doubted as authentic, because of its contrary to Quran and Hadis Mutawwatir textualy. Zakaria used comparative theory to proof the authenticity of hadis by comparing hadis in S}ah}i>h} al-Bukha>ri with Quran and Hadis Mutawwatir. One of hadis’ that criticized by Zakaria was hadis about angels cursed wife who denied the husband’s invitation for having sex. He stated that this hadis was contrary to Quran and the principles of Islamic doctrine which respect the dignity and honor of the women. Therefor that hadis must be doubted its authenticity. Zakaria’s thoughts about authenticity of hadis in S}ah}i>h} al-Bukha>ri was stated in his work, Jina>yat al-Bukha>ri, probably, has the same tendency with most contemporary muslim scholars who tried to reconstruct the interpretation of hadis which literally contraty to Quran, hadis mutawwatir, and Islamic doctrines. But Zakaria seems to criticize loudly with doubting the authenticity of hadis in S}ah}i>h} al-Bukha>ri.
Оцінка аналгетичної ефективності блокади квадратного м’яза попереку (Quаdratus Lumborum block), виконаного під контролем ультразвуку у дітей після апендектомії
Authors: Zaletskiy B V , Dmytriiev D V , Glazov E O , Vitkovskyi V L
Published: May 2019

Вступ. За даними літератури, для знеболення в періопераційному періоді використовують регіональні методи знеболення. Аналгетичну ефективнiсть блокад передньої черевної стiнки в педіатричній практиці вивчено недостатньо. Метою дослідження було оцінити аналгетичну дію блокади квадратного м’яза попереку (QLB) у педіатричних пацієнтів після апендектомії.

Методи. Дане дослідження було виконане на базі Вінницького національного медичного університету, м. Вінниця, Україна, з грудня 2018 по лютий 2019 року. Рандомізовані до групи Q (група з виконанням блокади QLB) та групи С (контрольна). Після отримання загальної анестезії групі Q виконано блокаду квадратного м’яза попереку (QL) з використанням 0,3 мл/кг 0,25 % бупівакаїну з одної сторони, та група C отримала контрольний блок з використанням 0,3 мл/кг 0,9 % хлориду натрію. Протягом перших 24 годин після операції біль у пацієнтів оцінювали за допомогою візуальної аналогової шкали (VAS) у спокої і при кашлі. Післяопераційний пацієнт контролював споживання морфіну, аналгезію, показники VAS та побічні ефекти.

Результати. Із 22 пацієнтів, у пацієнтів групи Q (n = 10) мала значно нижчі показники VAS-болю, ніж група C (n = 12) як у спокої, так і під час кашлю. Загальний рівень споживання морфіну був нижчим (5,3 ± 2,2) проти 12,4 ± 3,4 мг, р < 0,001) протягом 24 годин після операції.

Висновок. Як частина мультимодального знеболення після оперативних втручань з приводу апендициту, показники споживання морфіну та VAS-балів були значно нижчими серед тих, хто отримував 0,3 мл/кг 0,25 % розчину бупівакаїну, який вводили для блокади квадратного м’яза попереку, порівняно з групою контролю.
Частота експресії антигену CD 117 на бластних клітинах при мієлодиспластичному синдромі (МДС), гострій мієлоїдній лейкемії (ГМЛ)
Authors: Стародуб Г С , Горяїнова Н В , Треяк Н М , Гордієнко А І , Перехрестенко Т П , Кубарова В О
Published: May 2019

CD 117 (kit) є рецепторною тирозин-кіназою типу ІІІ, яка бере участь у клітинній сигнальній трансдукції клітин. Зазвичай kit активується шляхом зв’язування його ліганду, запускаючи каскад фосфорилювання, призводячи до транскрипції в клітинах різного типу. Така активація регулює апоптоз, диференціацію, проліферацію клітин.

Мета. З огляду на те, що мієлодиспластичний синдром (МДС) – це клонова патологія з високою здатністю до трансформації у ГМЛ, є актуальним вивчати експресії антигену CD 117 у хворих на МДС РАНБ І, РАНБ ІІ, ГМЛ.

Матеріал і методи. Проаналізовано дані 12 хворих на МДС, із них 7 РАНБ І та 5 з РАНБ ІІ і 11 хворих на ГМЛ, методом проточної лазерної цитофлюориметрії на FACScan (Becton Dickinson, США) з використанням програми LYSYS-II ver. 1.1 (Becton Dickinson, США).

Результати досліджень. Експресія антигену CD 117 визначена у 28,6 % обстежених хворих на МДС РАНБ І з показником CD 34+ 5,1 ± 0,5 % при 7,5 ± 1,5 бластних клітинах у КМ, у хворих на МДС РАНБ ІІ експресія CD 117 антигену спостерігалась у 80 % випадків при наявності 16,4 ± 1,5 % CD 34+ бластних клітин у КМ. У хворих на ГМЛ de novo в КМ виявлялось 62,4 ± 6,4 % CD 34+ бластних клітин, встановлено експресію CD 117 на 59,5 ± 4,5 % клітин у 81 % обстежених хворих.

Висновки. Динаміка експресії антигену CD 117 на бластних клітинах при МДС свідчить про активність патологічного процесу.
L’underpricing des entreprises financées par le capital-investissement
Authors: Awounou-N’Dri Honorine , Dubocage Emmanuelle
Published: May 2019

Cet article analyse l’impact de l’investissement graduel et de la syndication sur le niveau de sous-évaluation des entreprises financées par le capital-investissement lors de leur entrée en Bourse. L’analyse empirique exploite des données relatives à 260 entreprises introduites en Bourse sur Euronext-Paris et Alternext entre 1997 et 2013. La pratique de la syndication constitue un mécanisme de gouvernance efficace d’amélioration de la performance de l’introduction en Bourse en réduisant les coûts d’agence et l’asymétrie d’information entre les parties prenantes de cette opération.
Perceptions and Attitudes of Academic Staff Towards Agricultural Training in Kenyan Universities
Authors: Karanja Davis Njuguna , Wahome Raphael Githaiga , Kunyanga Catherine Nkirote , Onyango Cecilia Moraa
Published: May 2019

Agricultural productivity in Africa does not match that of the number of professional graduates working within the sector. This raises question on suitability of university training to needed graduate competencies. Under "PREPARE BSc project", ninety five lecturers selected from academic disciplines were interviewed to collect data on lecturers' perceptions and attitudes on learning environment, curriculum development, teaching and learning, and assessment activities. Over 80% of the respondents stated that curricula were adequate in content, but poorly aligned to teaching and learning activities. They (71.4%) thought they were competent in lecture and laboratory teaching methodologies, but the university learning environment (53.4%) and field training arrangements (73.9.%) were poorly aligned with the curricula. There was excessive emphasis on summative assessment (68.4%) at the expense of continuous assessment tests (formative assessment). A need was therefore identified to train staff on aligning curricula, teaching and assessment methods to learning environment and expected graduate competencies.
Friedel-Crafts benzoylation reaction of aromatic compounds using zinc oxide nanoparticles in deep eutectic solvent (choline chloride/urea) under microwave irradiation
Authors: Nguyen Hai Truong , Ngo Dung Thi Kim , Pham Thinh Nguyen Huu , Tran Phuong Hoang
Published: May 2019

Synthesis of zinc oxide nanoparticles (ZnO) which was found to be effective catalyst for Friedel-Crafts benzoylation reaction in the presence of deep eutectic solvent (DES). The method is one of the most important intermediates for preparing fine chemicals in the field of pharmaceuticals, which is a tool for organic syntheses of aromatic ketones. ZnO precursor was prepared from Zn(CH3COO)2.2H2O and H2C2O4.2H2O, ZnO nanoparticles were characterized by using X-ray Powder Diffraction (XRD), Scanning Electron Microscope (SEM). The benzoylation of aromatic compounds and benzoyl chloride using nanoparticles ZnO/ [CholineCl][Urea]2, under microwave irradiation afforded the desired products in high yields and short reaction times. The catalyst/solvent could be recycled several times without loss of efficient catalytic activity.
Expression Levels of the Uridine-Cytidine Kinase Like-1 Protein As a Novel Prognostic Factor for Hepatitis C VirusAssociated Hepatocellular Carcinomas
Authors: Buivydiene A. , Liakina V. , Valantinas J. , Norkuniene J. , Mockiene E. , Jokubauskiene S. , Smaliukiene R. , Jancoriene L. , Kovalevska L. , Kashuba E.
Published: May 2019

The expression levels of the two novel oncoproteins uridine-cytidine kinase like-1 (UCKL-1) and mitochondrial ribosomal protein S18-2 (MRPS18-2) were assessed in samples of hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) using immunohistochemistry. Tissue microarray (TMA) paraffin blocks were prepared from 42 HCC tumor samples with the corresponding peri-tumor tissues and from 11 tissues of a liver with HCV-induced cirrhosis. We found that the UCKL-1 signal in the liver tissues of the peri-tumor zone in the HCC samples was stronger than that in cirrhosis (50 49.44 vs. 24.27 14.53; p = 0.014). The MRPS18-2 expression was weak, and there was no differences between the groups (p = 0.26). Noteworthy, the UCKL-1 protein was expressed at higher levels in peri-tumor tissues in the cases of HCC recurrence; this was confirmed for 27 older patients (63.78 9.22 vs. 53.53 4.07 years, p 0.001), in parallel with enhanced UCKL-1 staining in former HCC nodules (62.69 50.4 vs. 26.0 30.19, p = 0.006) and microvascular invasion (p = 0.02). A multivariate analysis of prognostic factors for HCC recurrence showed that the best predictive factors for these conditions were UCKL-1 expression in tumor, vascular invasion, and HCC treatment modality, other than liver transplantation (odds ratios: 1.029, 18.143 and 11.984, R = 0.633, p = 0.002). In conclusion, the high UCKL-1 expression might be a prognostic factor for HCC relapse, in combination with age and microvascular invasion. MRPS18-2 protein expression has no prognostic significance in the cases of HCV-associated HCC.
Antitumor Vaccines Based on Dendritic Cells: From Experiments using Animal Tumor Models to Clinical Trials
Authors: Markov O. V. , Mironova N. L. , Vlassov V. V. , Zenkova М. А.
Published: May 2019

The routine methods used to treat oncological diseases have a number of drawbacks, including non-specific action and severe side effects for patients. Furthermore, tumor diseases are associated with a suppression of the immune system that often leads to the inefficiency of standard treatment methods. The development of novel immunotherapeutic approaches having specific antitumor action and that activate the immune system is of crucial importance. Vaccines based on dendritic cells (DCs) loaded with tumor antigens ex vivo that can activate antitumor cytotoxic T-cell responses stand out among different antitumor immunotherapeutic approaches. This review is focused on analyzing different methods of DC-based vaccine preparation and current research in antitumor DC-based vaccines using animal tumor models and in clinical trials.
Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
Authors: Selenina А. V. , Tsimokha А. S. , Tomilin А. N.
Published: May 2019

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are subjects of high interest not only in basic research, but also in various applied fields, particularly, in regenerative medicine. Despite the tremendous interest to these cells, the molecular mechanisms that control protein homeostasis in these cells remain largely unknown. The ubiquitin-proteasome system (UPS) acts via post-translational protein modifications and protein degradation and, therefore, is involved in the control of virtually all cellular processes: cell cycle, self-renewal, signal transduction, transcription, translation, oxidative stress, immune response, apoptosis, etc. Therefore, studying the biological role and action mechanisms of the UPS in pluripotent cells will help to better understand the biology of cells, as well as to develop novel approaches for regenerative medicine.
Predicting the Evolutionary Variability of the Influenza A Virus
Authors: Timofeeva T. A. , Asatryan M. N. , Altstein A. D. , Narodisky B. S. , Gintsburg A. L. , Kaverin N. V.
Published: May 2019

The influenza A virus remains one of the most common and dangerous human health concerns due to its rapid evolutionary dynamics. Since the evolutionary changes of influenza A viruses can be traced in real time, the last decade has seen a surge in research on influenza A viruses due to an increase in experimental data (selection of escape mutants followed by examination of their phenotypic characteristics and generation of viruses with desired mutations using reverse genetics). Moreover, the advances in our understanding are also attributable to the development of new computational methods based on a phylogenetic analysis of influenza virus strains and mathematical (integro-differential equations, statistical methods, probability-theory-based methods) and simulation modeling. Continuously evolving highly pathogenic influenza A viruses are a serious health concern which necessitates a coupling of theoretical and experimental approaches to predict the evolutionary trends of the influenza A virus, with a focus on the H5 subtype.
Change in the Content of Immunoproteasomes and Macrophages in Rat Liver At the Induction of DonorSpecific Tolerance
Authors: Karpova Ya. D. , Ustichenko V. D. , Alabedal’karim N. M. , Stepanova A. A. , Lyupina Yu. V. , Boguslavski K. I. , Bozhok G. A. , Sharova N. P.
Published: May 2019

Induction of donor specific tolerance (DST) by the introduction of donor cells into a recipients portal vein is one of the approaches used to solve the problem of transplant engraftment. However, the mechanism of DST development remains unclear to this moment. In the present work, we first studied the change in the content of immunoproteasomes and macrophages of the liver at early stages of the development of allospecific portal tolerance in rats by Western blotting and flow cytofluorimetry. On the basis of the data obtained, we can conclude that the induction of DST is an active process characterized by two phases during which the level of the proteasome immune subunits LMP2 and LMP7 in liver mononuclear cells, including Kupffer cells, and the number of Kupffer cells change. The first phase lasts up to 5 days after the beginning of DST induction; the second phase - from 5 to 14 days. In both phases, the level of the subunits LMP2 and LMP7 in the total pool of mononuclear cells and Kupffer cells increases, with maximum values on days 1 and 7. In addition, the total number of Kupffer cells increases in both phases with a shift in several days. The most noticeable changes take place in the second phase. The third day is characterized by a lower content of mononuclear cells expressing immunoproteasomes compared to the control value in native animals. Presumably, at this time point a window of opportunity appears for subsequent filling of an empty niche with cells of different subpopulations and, depending on this fact, the development of tolerance or rejection. The results obtained raise the new tasks of finding ways to influence the cellular composition in the liver and the expression of immunoproteasomes on the third day after the beginning of DST induction to block the development of rejection.
The Spatial Organization of the Intranuclear Structures of Human Brain Dopaminergic Neurons
Authors: Korzhevskii D. E. , Gusel’nikova V. V. , Kirik O. V. , Sukhorukova E. G. , Grigorev I. P.
Published: May 2019

We studied the intranuclear localization of protein nucleophosmin (B23) and ubiquitin in the dopaminergic neurons of human substantia nigra (n = 6, age of 25-87 years) using immunohistochemistry and confocal laser microscopy. Intranuclear ubiquitin-immunopositive bodies that morphologically correspond to Marinesco bodies were found to be present in substantia nigra dopaminergic (tyrosine hydroxylase-immunopositive) neurons but absent in non-dopaminergic neurons. The number of bodies varied from 0 to 6 per cell nucleus. Nucleophosmin (B23) was found in the neuronal nucleolus, with the nucleolus size being constant in the nigral neurons of each individual brain. All the observed neurons had only one large nucleolus with intense nucleophosmin immunoreactivity and a lightly stained region (1-2 m in diameter) that apparently represents the giant fibrillar center (GFC). An intensely immunostained nucleophosmin-containing granule was often observed at the GFC periphery. Double labeling demonstrated that nucleophosmin-immunoreactive nucleolus and ubiquitin-immunoreactive Marinesco bodies can occur both closely to and remotely from each other. Three-dimensional reconstruction indicates that rounded Marinesco bodies are polymorphic and often have a complex shape, with some flattening and concavities, which may be associated with contact not only with the nucleolus, but also, presumably, with other intranuclear structures free of ubiquitin or nucleophosmin. Ubiquitin-immunoreactive structures with a relatively small size (up to 1 m in length) and various clastosome-like shapes (Lafarga et al., 2002) often occur near Marinesco bodies. There were no cases of detection of ubiquitin in the nucleoli of dopaminergic neurons and nucleophosmin/B23 in typical Marinesco bodies. The obtained information may be helpful in unraveling the molecular mechanisms of the selective vulnerability of substantia nigra dopaminergic neurons to damaging factors.
Induction of ICAM-1 Expression in Mouse Embryonic Fibroblasts Cultured on Fibroin-Gelatin Scaffolds
Authors: Nosenko M. A. , Maluchenko N. V. , Drutskaya M. S. , Arkhipova A. Y. , Agapov I. I. , Nedospasov S. A. , Moisenovich M. M.
Published: May 2019

Culturing of allogeneic or autologous cells in three-dimensional bioresorbable scaffolds is an important step in the engineering of constructs for regenerative medicine, as well as for experimental systems to study the mechanisms of cell differentiation and cell-to-cell interaction. Artificial substrates can modulate the phenotype and functional activity of immobilized cells. Investigating these changes is important for understanding the fundamental processes underlying cellular interactions in a 3D microenvironment and for improving tissue-engineered structures. In this study, we investigated the expression of the ICAM-1 adhesion molecule in mouse embryonic fibroblasts (MEF) when cultured on gelatin-fibroin scaffolds. Increased expression of ICAM-1 in MEF was detected only under 3D culture conditions both at the mRNA and protein levels. At the same time, the MEF cultured on various substrates did not oerexpress MAdCAM-1, indicating the selective effect of 3D culture conditions on ICAM-1 expression. One possible mechanism for ICAM-1 induction in MEF is associated with the activation of AP-1, since expression of c-Fos and Junb (but not cJun and Jund) was increased in MEF in 3D. When cultured under 2D conditions, the expression level of AP-1 components did not change.
Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites
Authors: Tikhonov D. B. , Magazanik L. G. , Nagaeva E. I.
Published: May 2019

The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and pharmacology. Recently, the list of ASIC1a ligands has been rapidly expanding. It includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins. The information on the mechanisms of action and the binding sites of the ligands comes from electrophysiological, mutational and structural studies. In the present review, we attempt to present a systematic view of the complex pattern of interactions between ligands and ASIC1a.
Pengaruh Literacy Skills dan Task-Based Instruction terhadap Intelectual Skills Siswa Tingkat Dasar
Authors: Tamam Mohammad Badru
Published: May 2019

In a society that is changing, schools cannot provide intellectual costs from items of special knowledge for lifelong use. The shift that must occur in the content of teaching is a change from emphasis mainly on certain knowledge items that may soon become obsolete, into changes with intellectual skills that can be applied to a broad and mostly unexpected list of tasks and situations. This study aims to: 1) Assess Literacy skills and task-based instruction influencing students 'intellectual skills 2) Assessing Literacy skills and task-based instruction influences students' basic level of intellectual skills. This research is a type of survey research, namely research conducted using a questionnaire as a research tool. The purpose of survey research is to provide a detailed description of the background, traits, and characteristics that are typical of the case will be made into a general matter. In this study the object was a fifth grade student at SDN Kauman II with 15 students and SDN Kauman III Ngoro Jombang with 13 students. The method of sampling in this study is that this study uses a census system because all elementary level students are sampled. Data analysis using multiple linear regression with the help of spss v. 20. The results of the discussion can be summarized as follows: 1) Literacy skills and task-based instruction have an effect on students 'intellectual skills 2) Literacy skills and task-based instruction have an effect on elementary students' intellectual skills.
Pelaksanaan Pembelajaran Komunikasi Non-verbal Bahasa Arab dengan Bahasa Tubuh sebagai Pemahaman Kinesik Lintas Budaya
Authors: Ismail Isma'il
Published: May 2019

Arabic is a universal language, Learning Arabic cannot be separated from the social and environmental environment that surrounds it. Learning Arabic requires adaptation to the environment which is an integral part of educational institutions. Students are part of the learning process, after formal education is complete, then they again become one of the important elements in society. Non-verbal language is statement forms of personality or personality traits that are manifested in body movements. Arabic is also an interesting study, where Arabic is one of the dominant Semitic languages ​​and still persists today. Based on the focus of the study, this study aims to describe: The Implementation of Learning Arabic non-verbal communication with Body Language as a cross-cultural kinesic understanding. This research is "Library Research". The research data used is secondary data. The data collection technique used by the authors in this study is documentation. Data processing is carried out by conducting study activities, verification and reduction, grouping and systematization, and interpretation or interpretation so that a phenomenon has social, academic, and scientific value. While data analysis in this study was carried out during and after data collection using descriptive-critical-comparative methods, and content analysis methods. From the results of the analysis it was concluded that: 1) In its development language became a feature of a culture. At a minimum it becomes a differentiator between one community and another in terms of language use. 2) Since the first year of his life in the world, children take part in conversations using body language and non-verbal cues. Then little by little they learn linguistic codes of language, how codes represent objects, events and types of relationships between objects and events. They learn how to send and receive orders with spoken language. 3) The role of Arabic in national culture has taken an important part since the development of Islam in the archipelago in the XIII century and its role is still felt lexically and semantically
Peningkatan Kemampuan Berfikir Reflektif untuk Meningkatkan Retensi pada Mata Pelajaran Pendidikan Agama Islam di SMP Islam Brawijaya Mojokerto
Authors: Arief Muhammad Budi
Published: May 2019

When students study Islamic religious education, there are several problems that cannot be solved easily by students using the usual procedures used, students must understand at least being able to read the Qur'an, students must understand the science of jurisprudence, morals, and even the history of Islamic civilization and Arabic almost simultaneously. Often students find it difficult to determine the steps to be taken. For this reason, students need to recall the knowledge that has been held and stored in their memories. The purpose of this study was to describe reflective thinking skills to improve retention in Islamic Religious Education subjects at the Mojokerto Student Islamic Middle School. This research is a qualitative descriptive study, carried out in class IX students of Brawijaya Islamic University in Mojokerto in the academic year 2017/2018. The data collection method used is the interview method. The data obtained are then analyzed based on predetermined reflective thinking indicators. Data processing is carried out by conducting study activities, verification and reduction, grouping and systematization, and interpretation or interpretation so that a phenomenon has social, academic, and scientific value. While data analysis in this study was carried out during and after data collection using descriptive-critical-comparative methods, and content analysis methods. From the results of the analysis concluded: 1) Reflective thinking that must be developed by the teacher so that students can carry out activities that include activities: observing, reflecting, collecting data, considering moral principles, making estimates, considering strategies and actions. 2) At the stage of absorbing and storing learning outcomes (retention) with the knowledge possessed to interpret the problem at hand. At the stage of planning problem solving, students can determine the strategies or steps that will be used to answer test questions or problems in life
Hacia una economía de plataformas responsable
Authors: Cañigueral Bagó Albert
Published: May 2019

La economía de plataformas ha emergido con mucha fuerza en una amplia diversidad de sectores productivos (movilidad, turismo, finanzas, etc.). Estas plataformas están demostrando ser más eficientes desde un punto de vista de gestión, ofrecen más oportunidades de intercambio de valor entre los ciudadanos y reducen la huella ecológica en algunos casos. El análisis comple­to debe incorporar las externalidades negativas de las plataformas, así como los retos regulato­rios (licencias, laboral, tributos, etc.). Presentamos diversas herramientas y reflexiones que nos facilitan este análisis más completo al parametrizar una plataforma digital para medir su nivel de responsabilidad social.
Economía de plataformas y turismo en España a través de Airbnb
Authors: Ortuño Armando , Jiménez Juan Luis
Published: May 2019

Las plataformas online de alquiler de viviendas turísticas han experimentado un crecimiento destacado en España durante el último lustro, al igual que alrededor del mundo. Ello ha modificado en buena medida las pautas de consumo alojativo turístico y, en adaptación a ello, la normativa de aplicación. En el presente trabajo realizamos una aproximación cualitativa y descriptiva a la expansión de Airbnb en España, especialmente en los dos modelos de desarrollo turísticos predominantes en España (cultural en centros urbanos de grandes ciudades y residencial de «sol y playa»), al análisis de la literatura que evalúa sus efectos y a los cambios regulatorios aplicados en cada Comunidad Autónoma. Finalmente, se propone una metodología de second-best que podría reducir los efectos adversos que la regulación actual está generando.
Un futuro para la economía colaborativa y los nuevos modelos de negocio en las plataformas digitales
Authors: Ferrer Miguel , Maudes Antonio
Published: May 2019

La «economía colaborativa», economía de plataformas o economía P2P, constituye un mode­lo de negocio relativamente reciente basado en una utilización más eficiente de recursos econó­micos infrautilizados –bienes o servicios– a través de plataformas digitales dotadas de ambientes sociales que incentivan la confianza. A través de la colaboración digital entre expertos en la materia, este artículo pretende proporcionar al lector una previsión informada de las posibles líneas de evolución de la economía colaborativa en diversos sectores económicos. Asimismo, se proponen unas conclusiones para el mejor empleo y comprensión de esta nueva familia de mode­los de negocio por parte del sector privado y del sector público.
Report. Indagine su atteggiamenti e credenze verso l'uso di sostanze stupefacenti
Authors: Faillace Guido , Davoli Fedinando , Daidone Salvatore , Matera Cristina
Published: May 2019

The survey is inspired by the observation of repeated clichés, beliefs, preconceptions, emerged in interviews with consumers or drug addicts and during class discussions with students during the implementation of prevention projects. The young people involved are students aged between 14 and 16, still in the compulsory school age range. The contents that emerged prompted the investigation to verify misinformation or false information, as well as attitudes and disposition for use in an age group where "hearsay" can be the main source of information for the construction of attitudes and beliefs, despite the media opportunities to obtain scientific information on the issues in question. It has often been observed that the computerized medium is used to seek confirmation of street convictions using unscientific sites; that subjects who use so-called "light" substances tend to normalize the phenomenon with phrases like: "Everyone uses them, even the big ones". The research topics concern the perception of danger towards occasional-non-employee consumption; the confusion between therapeutic use and abuse; the cerebral implications of use; the incorrect interpretation of the messages on legalization (generally interpreted as a license to indiscriminate use); the idea that individual freedom authorizes the use of substances; the conviction of their intentions to abstention; the hope of remaining free from use and living in protected environments; the arrangement for use. The answers obtained concerned a sample of 564 students.Emerging data show that about 8 out of 10 students have a general knowledge of the damage and theawareness that the consumption of substances is a risky behavior, while in the remaining two out of 10 the openness to use can be seen. A portion between 15% and 25% proves to have knowledge based on the "heard".Between the ages of 14 and 16 4 out of 5 youngsters hope for a substance-free future. The openness to use is around 15%; a datum compatible with the surveys on the use of cannabis in the 15-year-olds offered by the Annual Report to Parliament.
C'erano una volta le tossicomanie e tossicofilie - uno sguardo fenomenologico al mutamento del paradigma delle dipendenze
Authors: Valdevit Andrea
Published: May 2019

The work traces the changes in the costumes of the "toxic worlds", of the phenomena of consumption anddependence in the last sixty years.It focuses on the clinic of the new dependencies and the behaviors of addiction without substances, according to the phenomenological theories.
Amerikan Ceza Muhakemesi Hukukunda Hukuka Aykırı Delillerin Dışlanması
Authors: KÖSE Metin
Published: May 2019

Amerikan hukukunda
anayasal haklar ihlal edilerek elde edilen deliller dışlanmaktadır. Delillerin
dışlanması, Anayasa’nın makul olmayan arama ve el koymalara karşı güvende olma
hakkı tanıyan Ek 4. maddesi; kendisine karşı tanıklık yapmaya zorlamama hakkı
tanıyan Ek 5. maddesi; ceza yargılamasında sanığa avukat yardımından yararlanma
hakkı tanıyan Ek 6. maddesi bağlamında mahkeme kararlarıyla oluşturulmuş
dışlama kuralları ve gözaltındaki bir kimseden gönülsüz olarak elde edilen
ikrarı değerlendirme dışı bırakan Miranda dışlama kuralı uyarınca
yapılmaktadır.Amerikan hukukunda
başlangıçtaki hukuka aykırı davranıştan türetilen deliller zehirli ağacın
meyveleri olarak nitelendirilir. Dışlama kuralları zehirli ağacın meyvelerinin
dışlanması öğretisiyle türev delilleri kapsayacak şekilde genişletilmiştir. Böylece
yalnız anayasal hakların doğrudan ihlal edilmesiyle elde edilen deliller değil,
ayrıca bu ihlalden dolaylı olarak elde edilen deliller de dışlanmaktadır.Delillerin dışlanmasındaki amaç kolluğun kötü
muamelede bulunmasını engellemektir. Bununla birlikte, dışlama kuralları ve
uygulamaları faydasına karşın toplumun yüksek bir maliyet ödediği yönünde geniş
eleştiri konusu yapılmıştır. Bu eleştirileri dikkate alan Birleşik Devletler
Yüksek Mahkemesi delilleri dışlamanın hukuka aykırı davranışı engelleme
olasılığının yetersiz olduğu durumlarda hem birincil hem de türev delillere
uygulanabilen bir takım istisnalar getirmiştir. İyi niyet istisnası, bağımsız
kaynak istisnası, zayıflatılmış kusur istisnası ve kaçınılmaz bulgu istisnası
olarak adlandırılan bu durumlarda polisin yaptığı hukuka aykırı davranış
sonucunda elde edilen delilin yargılamada kullanılmasına izin verilir.
Optimization of Proposal Management Arrangements as Learning Tools in Scientific Research Activities
Authors: Harjanto Rudy , P. Manurung Edward Boris , Lestari Arini Dwi
Published: May 2019

For a researcher, compiling or managing a research proposal is a significant step because this step dramatically determines the success or failure of all research activities. For this reason, management is needed from a management research activity, because it is one of the activities that are scientific. Management of research proposals or often referred to as research planning is one example of a management report that is described in detail from the study design that will be carried out to answer existing problems. In a term, there is an understanding of a proposal. It seems that a study is not only intended for individuals because the proposed word implies that something is still waiting for an answer or permission from another party. It is expected that with the management of a scientific research activity management has a clear purpose, which later can be useful as a study material about a matter and most importantly as a reference in making decisions for the benefit of the public or the government or private parties or companies.

Keywords: Management, Research, Research Activities
Analysis of Reading, Reference and Information Management on the Quality of Scientific Writing
Authors: Zarlis Muhammad , Astuti Sherly , Salamuddin Muhammad
Published: May 2019

In education, for educational instruments scientific writing is a very important thing. It requires an information management skill, information management is a library search, which can be done through a computer and guided by the internet. It can also be through the quality of reading used as a reference for scientific writing. In addition, in producing a paper also must know the management of writing, not only required to pay attention to the rules of standard language, but also must be able to convey ideas and ideas well and meet scientific criteria, such as making a quote or reference list used. This paper was written with the aim of improving the quality of research through reading material, making notes and avoiding plagiarism, references using the Harvard system for journals, books, and articles. Management of citing articles either CD or internet, writing, editing, storing references electronically, writing bibliography, and quotations.
Fitur Form Emailer Dalam Memaksimalkan Penggunaan Rinfo Form Pada Perguruan Tinggi
Authors: Handayani Indri , Aini Qurotul , Alfiansah Reza
Published: May 2019

Guna mempercepat pengisian ISAP dan Pemeriksaan ISAP, Perguruan Tinggi Raharja membutuhkan fitur yang dapat memonitoring perkuliahan, kehadiran dosen, dan kelengkapan silabus mata kuliah. Berdasarkan hasil penelitian pada ISAP iLearning Plus di Perguruan Tinggi Raharja belum ada sistem khusus yang berbasis online untuk memonitoring kehadiran dosen, maupun kesesuaian materi perkuliahan yang diberikan dengan Isian Satuan Acara Perkuliahan (ISAP) yang sudah di rencanakan. Dalam pengisian ISAP dosen masih datang ke koordinator iLearning Plus dan masih harus mengisi ISAP secara manual. Hal ini mengakibatkan proses pengisian ISAP dan memonitoring kehadiran menjadi tidak berjalan optimal. Oleh karena itu, rinfo form membantu memaksimalkan pengisian ISAP khususnya dosen iLearning Plus.

Kata Kunci: isian satuan acara perkuliahan (ISAP), Rinfo form, monitoring

In order to speed up charging and Inspection ISAP, Higher Education Prog requires features that can monitor the course , the presence of lecturers , and the completeness of the course syllabus. Based on the results of research on ISAP iLearning Plus in Higher Education Prog no special system for monitoring the presence of an online-based lecturer , as well as the suitability of the lecture material given by the Field Unit Class Events (ISAP), which has been planned. In charging ISAP lecturers still coming to Plus coordinator iLearning and still had to manually fill ISAP. This resulted in the charging process ISAP and monitoring presence into not running optimally. Therefore , rinfo form helps maximize charging ISAP especially lecturers iLearning Plus .

Keywords: stuffing unit lecture event ( ISAP ) , Rinfo forms , monitoring