bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimación de la especialización y del potencial turístico rural en Hidalgo, México
Authors: Cerón Monroy Hazael , Vargas Adame Nancy Maribel , Isunza Vizuet Georgina
Published: June 2023

Este trabajo aporta un “índice de especialización turística evaluado (IETE)” para identificar potencialidades de turismo rural en municipios del estado de Hidalgo, México. Si bien la especialización es clave en términos de productividad y competitividad, su estimación tiene limitaciones, que se corrigen con un ajuste metodológico. Ante ello, se emplea un análisis más robusto en comparación con (1) los parámetros cualitativos o empiristas comúnmente utilizados y (2) el índice de especialización (IEE) simple, basado en la proporcionalidad. Con el procedimiento propuesto, de los 84 municipios de Hidalgo se identificaron cuatro como especializados: Atlapexco, Huasca de Ocampo, San Bartolo Tutotepec y Tecozautla, donde predominan comunidades rurales con el potencial para implementar iniciativas de turismo rural bajo la expectativa de fomentar el desarrollo comunitario y regional. El IETE contribuye a la identificación rigurosa de los espacios rurales con potencialidades y genera las bases para diagnósticos productivos y socioculturales de zonas vulnerables.
Alternativas para el desarrollo sostenible del turismo pospandemia en los municipios de Apartadó, Arboletes y Necoclí del Urabá antioqueño colombiano
Authors: García Giraldo Paula Catalina , Rivera Martínez César Augusto , Rueda Posada David Andrés , Ortiz Cano Gloria Cristina , Alzate Díaz Hernán Antonio , Velásquez Agudelo Natalia
Published: June 2023

El artículo es resultado de un trabajo de investigación que se planteó como objetivo diseñar alternativas para el desarrollo sostenible del sector turístico pospandemia en los municipios de Apartadó, Arboletes y Necoclí, ubicados en la subregión del Urabá antioqueño colombiano. En términos metodológicos, se planteó como una investigación mixta de carácter analíticodescriptivo, que combina fuentes documentales de diversa índole, entre ellas, una encuesta a 203 operadores turísticos de la subregión, a la que se le aplicó un modelo bajo análisis factorial de coeficientes principales (ACP). Entre los resultados más significativos se destaca que los municipios seleccionados tienen una importante oportunidad de consolidarse como destinos turísticos sostenibles por la riqueza natural del territorio y su posición geográfica privilegiada. Sin embargo, se debe asegurar el aprovechamiento sostenible de los recursos para convertirlos en fuente de riqueza material al mismo tiempo que se los recupera y conserva para su disfrute por parte de las siguientes generaciones.
Seguridad internacional : una introducción crítica
Authors: Kahhat Farid
Published: June 2023

¿Hay más conflictos que hace cinco décadas? ¿Los intereses de los países son los mismos? ¿Las guerras afectan por igual a las mujeres y a los hombres? En esta publicación, que apunta a un público diverso, interesado en los conflictos internacionales, su desarrollo y sus repercusiones, se tratará de resolver estas y otras interrogantes. Seguridad internacional: una introducción crítica nos acerca a temas como el terrorismo, los conflictos armados, la guerra y otras amenazas a la seguridad de los países, con ejemplos de la Segunda Guerra Mundial, la Guerra Fría, el surgimiento de Al Qaeda, entre otros. El enfoque principal es el de la política internacional, pero también se incorporan perspectivas y aportes de otras disciplinas, como la psicología o la teoría organizacional.
Excavaciones en Chavín de Huantar
Authors: Burger Richard L.
Published: June 2023

Las investigaciones de este libro estuvieron diseñadas para estudiar los patrones de la antigua ocupación de Chavín de Huántar y su economía de subsistencia. Durante los años transcurridos desde la primera publicación de esta obra, se han efectuado escasas investigaciones en esta zona arqueológica debido al peligro que representaron las actividades de Sendero Luminoso. Por este motivo el presente texto, hoy en día, es tan relevante para los estudiantes e investigadores como hace una década atrás. Este volumen incluye varios añadidos al texto original. Algunos de éstos conciernen a la reciente publicación de los resultados de la excavaciones en la Galería de las Ofrendas entre 1966 y 1967. Asimismo se han corregido varias inexactitudes introducidas previamente en la bibliografía arqueológica.
Arguedas en el Valle del Mantaro
Authors: Pinilla Carmen María
Published: June 2023

El lector de este libro hallará en las cartas, en las libretas, en la encuesta sobre la feria de Huancayo, en sus proyecciones y esperanzas, al novelista, al antropólogo, al hombre que ama y estudia, sin amuletos ni fetiches.
Aguas en el desierto : los puquios de Nasca
Authors: Schreiber Katharina Jeanne , Lancho Rojas Josué
Published: June 2023

Este trabajo no solo explica la invención de esta tecnología por los anitguos peruanos, sino que conjuga las disciplinas de la etnohistoria, la etnoarqueología y la prospección arqueológica para establecer la distribución e importancia del sistema de los puquios mediante el examen de una porción adecuada del territorio total de la cultura Nasca.
Los rostros silenciosos : los huacos retrato de la cultura Moche
Authors: Woloszyn Janusz Z.
Published: June 2023

Valioso estudio dedicado a la enigmática cerámica andina prehispánica de los huaco retratos de la cultura Moche. Se investiga por qué en aquella sociedad surgió la necesidad de crear tales artefactos, así como quiénes eran los sujetos representados.
Historia de la antropología
Authors: Marzal Manuel M.
Published: June 2023

Esta obra, a pesar de su extensión de más de mil quinientas páginas, es un manual de Historia de la antropología en tres volúmenes, que tratan de la antropología indigenista, cultural y social, respectivamente. La Antropología indigenista recoge un siglo de reflexión colonial (1550- 1650) sobre las sociedades indígenas de México y Perú, medio siglo de reflexión republicana (1920-1970) sobre los indios redescubiertos por el Indigenismo, tras un siglo de la Independencia que los había convertido en simples ciudadanos, y más de un cuarto de siglo (1970-1997) de reflexión sobre los pueblos indios, a raíz del nacimiento del Indianismo. La Antropología cultural expone, en su primera parte, los esquemas evolucionistas y difusionistas sobre el desarrollo de las sociedades por estudiosos de distintas disciplinas, que crean una nueva ciencia sobre los pueblos “primitivos”, a la que llaman antropología, y en la segunda parte, el estudio de dichos pueblos por antropólogos de Estados Unidos, dirigidos por Boas, con el paradigma de la cultura, definida como modo de ser colectivo. Y la Antropología social presenta, en su primera parte, el estudio de la estructura y la función de las sociedades primitivas por los antropólogos ingleses seguidores de Malinowski y Radcliffe-Brown, y en la segunda parte, el estudio de dichas sociedades como hechos sociales totales por los antropólogos franceses seguidores de Mauss.
El mundo andino : población, medio ambiente y economía
Authors: Murra John V.
Published: June 2023

Se ha reunido en este libro veintidós artículos de John V. Murra sobre la historia andina, escritos y/o publicados en los últimos cuarenta años. Algunos de ellos no habían aparecido hasta ahora en castellano y se hallaban contenidos únicamente en revistas especializadas de corto tiraje. El trabajo de Murra sobre la cultura andina se distingue por su enfoque etnohistórico; es decir, por la convergencia de los métodos de la antropología y la historia. Su análisis incorpora, además, mucha información proveniente de otras disciplinas, como la arqueología, la botánica, la metalurgia, la geografía, la ecología, la agronomía y la lilngüística. Fue el iniciador de una relectura de las Crónicas de la Conquista y del uso de fuentes administrativas españolas, como las Visitas o los informes burocráticos de Polo de Ondegardo, para reconstruir la historia del Tawantinsuyu.
Eye Movement Desensitization and Reprocessing Therapy in Chronic Fatigue Syndrome: A Single-Case Experiment Testing the Effect on Persistent Negative Evaluation of Fatigue
Authors: Bouman Sacha , Müller Fabiola , Onghena Patrick , Knoop Hans
Published: June 2023

Background:While cognitive behavioral therapy (CBT) for chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) can lead to the normalization of fatigue levels and resumption of activities, a subgroup of patients still evaluates fatigue negatively.

Objective:The objective was to investigate whether eye movement desensitization and reprocessing (EMDR) therapy leads to a less negative evaluation of fatigue.

Method:This was a randomized single-case experimental study. Five CFS/ME patients (all female, mean age of 35 years), who had completed CBT but still evaluated fatigue negatively, received EMDR therapy. The primary outcome, that is, negative evaluation of fatigue, was assessed daily (three items, e.g., “My fatigue is frustrating”). During EMDR therapy sessions, distress in response to a selected image was measured. Clinical assessments were performed before, directly after, and one month after EMDR therapy.

Results:During EMDR therapy sessions, all patients reported high distress related to memories of having CFS/ME. EMDR therapy led to a reduction in this distress. Daily measured negative evaluations of fatigue declined in three patients, albeit not significantly. Three of five patients showed clinically relevant improvement in evaluations of fatigue on clinical pre-/post measures.

Conclusion:EMDR therapy can reduce emotional distress associated with fatigue, but it is unclear whether it can change its negative evaluation.
Triadic Therapy Based on Somatic Eye Movement Desensitization and Reprocessing for Complex Posttraumatic Stress Disorder: A Pilot Randomized Controlled Study
Authors: Wakusawa Keisuke , Sugiyama Toshiro , Hotta Hiroshi , Wada Kohei , Suzuki Futoshi , Morimoto Takeshi , Shiino Tomoko , Tomoda Akemi
Published: June 2023

The triadic therapy based on somatic eye movement desensitization and reprocessing (EMDR) for complex posttraumatic stress disorder (TSP) is a combination therapy, which comprises simplified EMDR, a triplet of micro-dose medicines, and a pair of Chinese medicines. The EMDR procedure is a tactile bilateral stimulation on the body surface with minimum verbal intervention within 15 minutes every two weeks in a period of 2–3 months. In this study, 22 adult patients were treated with TSP. The Impact of Event Scale—Revised, Beck Depression Inventory (second edition), and Global Assessment of Functioning scores of the patients were significantly improved. Moreover, TSP is a safe treatment procedure in terms of titration, cost-effectiveness, and time-effectiveness. It could also treat multiple difficulties in patients with cPTSD from medical problems to socioeconomic problems.
Pathogenicity test bacteria from Oreochromis niloticus and Clarias gariepinus aquaculture ponds
Authors: Hardi Esti Handayani , Halim Aldi M. , Nugroho Rudy Agung , Mawardi Mira , Isnansetyo Alim , Mariana Lusiastuti Angela , Rahayu Widianingsih , Niklani Andi , Saptiani Gina
Published: June 2023

Present research aimed to examine the pathogenicity opportunities of some bacteria which were isolated from freshwater aquaculture ponds to some fish Oreochromis niloticus, Clarias gariepinus, and Pangasius pangasius. The bacteria were isolated from the water and feces of O. niloticus and C. gariepinus aquaculture in Samarinda, which were identified as Escherichia coli, Enterobacter cloacae, and Enterobacter amnigenus. An 0.1 mL-1 of each bacteria was intramuscular injection and evaluated the clinical signs, eksternal pathology, and fish mortality. The freshwater fish using in this research were Oreochromis niloticus, Clarias gariepinus, and Pangasius pangasius with size 10-15 g from Loa Kulu, Kutai Kartanegara Regency, East Kalimantan, Indonesia. The result showed that each bacteria caused mortality in fish: E. coli bacteria caused fish mortality 23.33-66.67%; E. cloacae 10.00 to 90.00%; and E. amnigenus by 3.33-56.67%. The average death time of E. coli and E. amnigenus in all three fish were under 48 hours, while E. cloacae caused mortality less than 48 hours in C. gariepinus and P. pangasius. In conclusion, E. coli, E. cloacae, and E. amnigenus are putative pathogenic bacterium in O. niloticus, C. gariepinus, and P. pangasius.
Politerapia e aging in HIV: 6 anni di esperienza di un ambulatorio multidisciplinare.
Authors: Cattaneo Dario , al. et
Published: June 2023

Background:
La gestione dell'infezione da HIV presenta ancora alcune sfide importanti per il clinico, soprattutto nei pazienti più anziani che spesso presentano comorbidità legate a età e politerapia complessa.
Obiettivo:
Descrivere i risultati della nostra esperienza di 6 anni con un ambulatorio (Gestione Ambulatoriale Politerapie [GAP]) per la gestione della politerapia nelle persone che vivono con HIV (PLWH).
Metodi:
Caratteristiche demografiche, regimi antiretrovirali, numero e tipo dei farmaci concomitanti sono stati raccolti in tutti i PLWH inclusi nel database dell’ambulatorio GAP da settembre 2016 a settembre 2022. Le terapie sono state stratificate in base al numero di farmaci anti-HIV (regimi duplici o triplici) e sulla presenza del farmaco-potenziante (ritonavir o cobicistat).
Risultati:
556 PLWH sono stati inclusi nel database dell’ambulatorio GAP. Complessivamente, i pazienti arruolati assumevano 4,2±2,7 farmaci (range 1-17) oltre alla terapia antiretrovirale. Il numero dei farmaci concomitanti aumentava notevolmente con l'età (3,0±2,2 vs. 4,1±2,5 vs. 6,3±3,2 confrontando <50 vs. 50-64 vs. >65 anni; p<0,001 per tutti i confronti).
I PLWH in duplice terapia antiretrovirale erano significativamente più anziani (58±9 vs. 54±11 anni; p<0,001) ed erano trattati con più farmaci (5,1±3,2 vs. 3,8±2,5; p<0,001) rispetto a quelli in terapia triplice. Nei pazienti (n=198) con due visite è stata osservata una significativa riduzione dei regimi antiretrovirali farmaco-potenziati (53% vs. 23%; p<0.001) e del numero di terapie concomitanti (4.0±2.9 vs. 3.1±2.2 farmaci, p<0.001
Conclusioni:
L'elevata prevalenza della polifarmacia nei PLWH, specialmente tra gli anziani, pone questi pazienti ad alto rischio di interazioni farmacologiche clinicamente rilevanti.
Un approccio multidisciplinare che coinvolga medici e farmacologi clinici potrebbe aiutare a ottimizzare i regimi terapeutici.
As tanagras como objeto de arte no século XIX e os impactos para a pesquisa arqueológica
Authors:   Universidade de São Paulo, Freitas Ana Paula de Souza
Published: June 2023

As pequenas estatuetas gregas de período helenístico (séc. III-I a.C.) que conhecemos como Tanagras (figuras 1, 2, 3 e 4) eram abricadas em terracota (argila modelada e cozida em forno apropriado) e mediam entre 10 e 30cm de altura, representando em sua maioria meninas e jovens mulheres. As estatuetas chamam a atenção por serem consideradas esteticamente “belas” e bastante diferentes de todos os estilos de estatuetas previamente produzidas na Grécia Antiga; eram produzidas com o uso de dois moldes, um para a frente e outro para as costas; após a modelagem, os detalhes eram adicionados individualmente e após a queima eram pintadas com diferentes cores vibrantes.
Censura coletiva: a arte como espelho de problemáticas relativas às questões de sexualidade
Authors:   Universidade Federal do Rio de Janeiro, Meireles Ana Renata
Published: June 2023

Ao tratarmos de um conceito extremamente consolidado, inclusive sob o prisma político13, faz-se oportuno iniciarmos nossa reflexão a partir da ferramenta que nos dispõe as significações de forma mais clara: o dicionário. A partir dessa busca, aferimos uma variedade de definições, das quais algumas nos interessam de forma direta.
Revisando a trajetória da curadora e crítica de arte Maria Eugênia Franco: estudos iniciais
Authors:   Universidade de São Paulo, Leite Andrea Andira
Published: June 2023

Com esta comunicação proponho apresentar os mais relevantes campos de atuação da escritora, bibliotecária, curadora e crítica de arte Maria Eugênia Franco (1915 – 1999). Tais apontamentos poderão colaborar para a compreensão de sua influência intelectual no meio artístico-cultural, desempenhada entre os anos 1940 e 1970 na cidade de São Paulo. Para tanto, considero oportuno o exercício de discorrer sobre a atuação de Franco nas áreas de curadoria e da crítica de arte para além daquela mais conhecida, como articuladora e gestora da Seção de Arte da Biblioteca Pública Municipal, criada em 1945, e posteriormente do Departamento de Informação e Documentação Artísticas (IDART), criado em 1975 e hoje extinto.
50 anos da Coleção Constantini: da estreia com um Presas, mirando um Bernini, à obsessão por um Rivera
Authors:   Centro Universitário SENAC, Marques Cristiélen Ribeiro
Published: June 2023

Obstinação e entusiasmo pela arte, visão mercadológica e construção de um legado artístico-histó-rico-cultural latino-americano, num contexto globalizado, são aspectos marcantes na trajetória de 50 anos, desde o embrião que daria origem à Coleção Costantini. Neste artigo, estes aspectos serão apresentados por meio de dois pilares temáticos: como se formou e evoluiu a coleção, com as mudançasnos critérios de escolha e aquisições, para que se chegasse à constituição atual; e o da forma de trazê-la ao público,movimento que se iniciou nos anos 1990 em parceria com outros museus, passou pelo estabeleci-mento de um acervo em um espaço museológico próprio, o Malba, e incluiu uma revisão curatorial na ex-posição comemorativa de 15 anos da instituição, a Verboamérica.
A expografia e o arquiteto: reflexões sobre a montagem de uma exposição
Authors:   Universidade Federal do Paraná, Fabris Yasmin , Corrêa Ronaldo de Oliveira ,   Universidade Federal do Paraná
Published: June 2023

Este artigo tem como objetivo apresentar uma reflexão sobre os modos de organizar artefatos em uma exposição. Para isso, analisamos as narrativas dos profissionais envolvidos na elaboração de uma mostra, com destaque ao arquiteto responsável pela mediação entre as ideias curatoriais e a monta-gem dos objetos na arena expositiva. Tratamos da encenação da Puras Misturas, que esteve em cartaz em São Paulo-SP de abril a novembro de 2010, no Pavilhão das Culturas Brasileiras. Temos por propósito com-preender como o arquiteto Pedro Mendes da Rocha, responsável pelo desenho espacial da mostra, narrou sobre as soluções espaciais que foram estruturadas na expografia. Nos atentamos, portanto, aos modos como os objetos foram organizados no ambiente museológico e como, parao arquiteto, a montagem estava articulada com os preceitos idealizados pelas curadoras.
Correlation Between Climate Indicators and COVID-19 Pandemic in Nigeria, Ghana, and South Africa
Authors: Bakare-Aremu Tunde Abubakar , Ibrahim Kekere Sule , Baba-Umar Saadatu , Mamman Rakiya
Published: June 2023

This study examines the relationship between climatic indicators (maximum temperature, minimum temperature, precipitation, and relative humidity) and the spread of COVID-19 using weekly data of confirmed cases and death rates from 3/25/2020 to 12/30/2020 for Nigeria, South Africa, and Ghana. Using an ex-post research design and descriptive method of analysis, the results of the study confirm evidence of correlation between climatic variables and the spread of the COVID-19 virus among the three selected countries. However, the policy recommendation that emanates from this study is that climate mitigation policies can be promoted as pandemic prevention policies, thus making a stronger case for their implementation to forestall future reoccurrence.
Financial Performance of Islamic Banks: A Comparative Analysis Before and During The COVID-19 Pandemic
Authors: Pahlifi Resa , Yanti Dharma , Norvadewi
Published: June 2023

The protracted pandemic has an impact on the Islamic banking industry. Comparing the financial performance of Islamic financing before and during the COVID-19 outbreak helped to evaluate the impact of this factor. This type of quantitative research utilizes secondary data in the form of monthly financial reports from the Financial Services Authority’s website for 2018–2021. The variables used are ROA, FDR, BOPO, NPF, and CAR. Before and throughout the COVID-19 epidemic, Islamic banks demonstrated varied financial performance levels as measured by the ratios of ROA, FDR, BOPO, and CAR. ROA and CAR ratios have risen throughout the COVID-19 epidemic. During the COVID-19 pandemic, the FDR, BOPO, and NPF ratios declined. The ratio of BOPO to CAR is the finest and most consistent of these five ratios, ranking first (very healthy) before and during the pandemic. The ROA ratio for FDR and NPF remains standard, with an average ranking of second (healthy). The bank’s condition stayed normal and healthy over the 2018–2021 period, both before and after the COVID–19 epidemic, despite variations in the financial performance of Islamic banks as indicated by the ROA, FDR, BOPO, NPF, and CAR ratios.
The Influence of Administrative Costs, Profit Sharing and Pick Up Services on Customer Decisions to Choose Tadhabur Saving Products (Study at BPRS Lantabur Tebuireng, Lamongan Branch)
Authors: Vera Ayu Mandasari  , Nasrulloh Nasrulloh
Published: June 2023

Financial institutions in Indonesia, both conventional and sharia, have led to increasingly fierce competition both in terms of improving service quality, providing facilities and products offered. One of the sharia financial institutions in Lamongan is BPRS Lantabur Tebuireng. This research is a quantitative study, the population in the study was 200 customers of tadhabur savings and the sample used was 67 customers using the Slovin formula. The data analysis method uses SPSS Statistics 26. The results of this study show that simultaneously, the variables of administrative costs, profit sharing and pick-up services have a significant effect on the customer’s decision to choose a tadhabur savings product. Partially, administrative costs affect the customer’s decision to choose a tadhabur savings product. Profit sharing (X2) affects the customer’s decision (Y) to choose a tadhabur savings product and ball pick-up services affect the customer’s decision to choose a tadhabur savings product.
The Effects of Money Supply on Exchange Rate: Evidence of Dornbusch Overshooting Model in Indonesia (2000-2021)
Authors: Syamad  , Rossanto Dwi Handoyo
Published: June 2023

This study aims to analyze the effects of money supply on exchange rate in Indonesia and to investigate whether there is an application of the Dornbusch Overshooting Model. The Autoregressive Distributed-Lag (ARDL) method is used to analyze short-term and long-term effects and uses time-series data from 2000:Q1 to 2021:Q4. The results of this study show that the long-term coefficient of the money supply has a smaller effect on the depreciating exchange rate than the short-term coefficient. Based on the estimation results, it can be concluded that there is an application of the Dornbusch Overshooting Model in Indonesia. A further implication of this research is that the factors that influence exchange rate fluctuations are of great concern in an effort to maintain exchange rate stability. For example, growth in the money supply because a 1 percent change in the money supply results in a change of more than 1 percent in the exchange rate. In addition to the money supply, other variables such as inflation and interest rates also have a large influence on changes in exchange rates and have different magnitudes of influence in the short and long-run.
Can alpha-synuclein be both the cause and a consequence of Parkinson's disease?
Authors: Chen Kang , Guo Yu-Jie , Lei Peng , Finkelstein David I.
Published: June 2023

Alpha-synuclein (α-syn) is a presynaptic and nuclear protein that has been inextricably linked to Parkinson’s disease (PD). It regulates the presynaptic activities of neurons, but its aggregation and spreading have been associated with a group of diseases termed synucleinopathies. Here, we examined the commonly held view that α-syn caused disease and explored the concept that α-syn aggregation may be a consequence of pathobiology. Future therapies may need to encompass α-syn both a cause and consequence of the disease process.
Authors: Arsil Poppy , Hidayat Hety Handayani , Wijayanti Riski Febri
Published: June 2023

The halal product guarantee system, also referred to as SJPH, is an integrated system that was created, implemented  and used to control products, production processes, raw materials, and procedures. The objecytve of this study is to identify  and design the main criteria of the SJPH. By using  qualitatif descriptive exploratory method, a semi-structured questions, was used to interview the key informant. They consist of  the leader, vendor and staff  of canteen using convenience sample method . A total of 15 key informants  were interviewed.  Data analysis used a thematic approach. The findings demonstrated that Sudirman Halal Canteen had satisfied the SJPH requirements, which included dedication and responsibility, ingredients, a halal production process, a product, and evaluation and monitoring.
PENGARUH KOMBINASI PROSES TERMAL DAN JENIS KEMASAN TERHADAP MUTU CIMPLUNG SINGKONG SIAP SAJI
Authors: Ritonga Abdul Mukhlis
Published: June 2023

Cassava cimplung is a traditional processed food made from cassava which is boiled in coconut sap water. Cassava has not been widely produced in ready-to-eat packaging as a selling value food. This is because cimplung is a semi-wet food so it easily spoils and does not last long. In an effort to maintain the quality of cassava cimplung, in this study a thermal pasteurization process was carried out with variations in the length of 10 minutes and 15 minutes and the use of EVOH (Ethylene Vinyl Alcohol) and boilpack packaging. Quality parameters observed included texture, pH, color, and brix content for 6 weeks of storage. The aims of this study were 1) To determine the effect of packaging type on the quality of cassava cimplung, 2) To determine the effect of pasteurization time on the quality of cassava cimplung, and 3) To determine the interaction effect of packaging type and pasteurization duration on the quality of cassava cimplung. The results of this study were 1)The treatment of the type of packaging was significantly different on the value of texture, pH, and color but was not significantly different on the brix content of cassava cimplung, 2) Pasteurization time treatment was significantly different to color value but not significantly different to texture, brix content, and pH of cassava cimplung, and 3) The interaction between the type of packaging and the duration of pasteurization was not significantly different on all quality parameters of cassava cimplung
Quality Characteristics of Honey Pineapple (Ananas comosus (L.) Merr.) with Minimally Processed Based on the Effect of Packaging Type
Authors: Syska Kavadya
Published: June 2023

Fresh fruit that is minimally processed is susceptible to damage due to loss of natural protection, including honey pineapple. One storage technique that can minimize damage to minimally processed fruit is low temperature storage using plastic film packaging. The purpose of this study was to examine the effect of the type of packaging on changes in the quality of minimally processed fruit. Storage was carried out at 5˚C, 10˚C, and 27˚C. The types of packaging used are stretch film (SF) and low density polyethylene (LDPE) packaging. Quality changes observed included weight loss, moisture content, hardness, and total dissolved solids. The results showed that changes in the quality of honey pineapple during storage were influenced by temperature and type of packaging. LDPE packaging is not highly recommended for minimally processed honey pineapple packaging. Based on observations of weight loss, moisture content, hardness, and total dissolved solids, the best packaging for minimally processed honey pineapple storage is stretch film packaging stored at 10˚C.
Development of Specialty Robusta Coffee with Saccharomyces Cerevisiae Fermentation to Improve Coffee Quality
Authors: Syska Kavadya , Ropiudin Ropiudin
Published: June 2023

Robusta coffee is one of the plantation commodities that has an important role in economic activities in Indonesia. Coffee is one of Indonesia's export commodities which is quite important as a foreign exchange earner for the country. Indonesia is listed as the fourth largest coffee producer after Brazil, Vietnam and Colombia. However, in the export market, Indonesia's coffee is still in ninth place. Post-harvest handling of coffee at the farm level generally produces low-quality, random coffee. Therefore, it really needs to be improved in quality to increase competitiveness in the international market. One alternative that is seen as effective is the improvement of the processing process to produce robusta coffee into fine robusta coffee. This study aims to determine the best yeast starter concentration and determine the best fermentation time to produce specialty coffee in the form of fine robusta coffee. This study used two factors, namely yeast concentration using Saccharomyces cerevisiae which included three levels (2%; 3%; 4%) and fermentation time with 3 levels namely 8, 10 and 12 hours. Repetition is carried out three times. The response variables observed were pH and temperature during fermentation, percentage of unpeeled beans, physical quality of rice coffee, density of kamba coffee rice, increase in roast volume, and taste quality. Data were analyzed using Analysis of Variance (ANOVA) with a confidence level of 5% if the ANOVA results showed a significant difference, followed by the Duncan Multiple Range Test (DMRT). The best results were in the R3F3 treatment (4% concentration and 12 hours time) which could produce coffee with the specialty/fine robusta flavor category. Yeast concentration has a significant effect on pH and temperature after fermentation. Meanwhile, the duration of fermentation has a significant effect on pH and temperature and the percentage of seeds that are not peeled. The results of the organoleptic test of the concentration of yeast and the duration of fermentation had a significant effect on the brewing of coffee and the panelists liked it.
KONSTRUKSI MAKNA DAN SIMBOL ROMANTIK DALAM PUISI-PUISI ARCO TRANSEPT DENGAN PENDEKATAN SEMIOTIKA PIERCE
Authors: Setyawati Christina Natalia , Munaris Munaris , Prasetyo Heru
Published: June 2023

Sebagai salah satu karya sastra yang menggunakan bahasa konotatif, simbolis, penuh metafora estetis, puisi memiliki nilai implisit dalam baris kata atau analogi yang dirangkai untuk menampilkan pesan dengan cara yang berbeda. Puisi-puisi Transept sarat akan tanda dan pesan implisit, membuat penulis tertarik mengkaji beberapa puisinya dengan pendekatan semiotika Pierce untuk mengonstruksi makna puisi. Penelitian ini diharapkan dapat memberikan kontribusi dalma mengembangkan pemahaman tentang puisi dari perspektif semiotika, memberikan wawasan lebih luas mengenai bahasa dan budaya. Melalui metode kualitatif deskriptif, penulis menguraikan ikon, simbol, dan indeks dalam beberapa puisi Transept. Hasil penelitian yang diperoleh berupa penemuan 8 simbol, 7 ikon, dan 2 indeks dalam puisi “Jiwa” yang menekankan rasa kehilangan seperti badai laut yang mengombang-ambingkan perahu; 8 simbol, 8 ikon, dan 3 indeks pada puisi “Di Tubuh Bumi Kita Tumbuh dengan Tabah Ibu” yang menjadikan ibu dan semesta sebagai analogi cinta; 8 simbol, 5 ikon, dan 4 indeks dalam puisi “Sepetak Rumah” yang menjadikan Pulau Sumatera representasi mimpi besar dan sepetak rumah sebagai mimpi kecil; 9 simbol, 8 ikon, dan 7 indeks dalam puisi “Biarkan Kenangan Menjelma Daun” yang menjadikan pohon sebagai representasi cinta dan guguran daun sebagai kenangan.
Pressure behaviors and isothermal kinetics of magnesiothermic reduction of titanium tetrachloride in a semi-batch reactor
Authors: Wang Wenhao , Wu Fuzhong
Published: June 2023

There is still no consensus on the pressure behaviors, thermal hazard, reaction pathways, and kinetic characteristics of magnesiothermic reduction of TiCl4, and theoretical innovations are required for further research of titanium sponge metallurgy. We determined efficient reaction pathways via chemical reaction stoichiometry methodology and proposed an innovative isothermal kinetic modeling approach for the magnesiothermic reduction of TiCl4. The net chemical reaction rate of the titanium sponge decreased with decreasing feeding rate of TiCl4 and with increasing gauge pressure, to relieve its rapid pressurization and thermal runaway. The reaction order and activation energy were α = 1.30 and Ea=60.85 ± 4.58 kJ·mol-1 at temperature range of 1053.0 K to 1073.0 K, respectively. And reaction order and activation energy were α = 1.50 and Ea=56.46 ± 1.31 kJ·mol-1 at temperature range of 1073.0 K to 1123.0 K, respectively. The self-heating of magnesiothermic reduction of TiCl4 causes its self-acceleration. And the autocatalytic effect of the sponge structure of the new-formed may play an irreplaceable role.
Attenuated adenomatous polyposis with MSH6 variation: two case reports
Authors: Kim Kyoung Min , Lee Min Ro , Ahn Ae Ri , Chung Myoung Ja , Ha Gi Won
Published: June 2023

Background: Adenomatous polyposis (AP) is a genetic disorder characterized by the occurrence of numerous adenomatous polyps in the colon and rectum and can be classified into classical AP (CAP) and attenuated AP (AAP). AAP is diagnosed when the number of observed adenomas is between 10 and 99. The detection of AAP is significantly increasing mainly due to the improvement of the imaging technique and application of the screening program for colorectal cancer detection. Currently, the germline variations of the APC and MUTYH genes are reported as the main cause of CAP. However, the underlying genetic basis of AAP is not well understood. In this study, we report two cases of AAP with MSH6 variations.
Case reports: The two patients had multiple colon polyps and were diagnosed with AAP. The two received genetic consultation; and, for follow-up purposes, both patients agreed to be tested for an underlying genetic condition through next generation sequencing (NGS). Germline MSH6 variations were detected in both patients.
Conclusion: Minor portion of AAP can cause by genetic mutation in MSH6, and further research is needed.
The impact of a health promotion program on toddlers´ socio-emotional development: a cluster randomized study
Authors: Duarte Ana , Martins Silvana , Augusto Cláudia , Silva Maria José , Lopes Luís , Santos Rute , Rosário Rafaela
Published: June 2023

Background
The first three years of life are a critical period for the development of socio-emotional skills, highlighting the importance of socio-emotional development in early childhood. This study aimed to evaluate the effectiveness of a health promotion intervention program on the socio-emotional development of children aged 12 to 42 months during the COVID-19 pandemic.
Methods
A total of 344 children from 15 childcare centers participated in this study, with six centers in the intervention group and nine in the control group. Childcare teachers in the intervention group received a six-month training program aimed at promoting healthy lifestyles, including topics such as diet, sleep, physical activity, and sedentary behavior. Sociodemographic and anthropometric measures were assessed at baseline, and socio-emotional development was assessed using the Bayley Scales of Infant and Toddler Development – Third Edition (Bayley-III) at baseline and post-intervention.
Results
Intervened children whose mothers had a lower education level demonstrated significantly higher socio-emotional development than the controlled children (B = 19.000, p = 0.028), while no significant difference was observed in children with mothers from higher education levels.
Conclusion
These findings suggest that intervention programs for childcare teachers can be effective in promoting healthy socio-emotional development in children from socioeconomically disadvantaged backgrounds. Future intervention programs should consider tailoring their approaches to target disadvantaged populations.
Trial registration
This cluster randomized controlled trial was registered in the Clinical Trials database/platform on 09/09/2019 (number NCT04082247).
Do simulation exercises affect pharmacy students’ self-efficacy in providing pharmaceutical care according to Bandura’s self-efficacy theory? – a pilot study
Authors: Plewka Beata , Waszyk-Nowaczyk Magdalena , Cerbin-Koczorowska Magdalena , Przymuszała Piotr , Osmałek Tomasz
Published: June 2023

Introduction. The transformation of the role of a pharmacist from a drug dispenser to an advisor and patient educator, partially accelerated by COVID-19 pandemic, requires a thorough change in the pharmacy curriculum. Preparation for the provision of modern pharmaceutical services requires the use of the most advanced teaching methods, such as pharmaceutical simulation. Knowledge alone does not guarantee the students’ readiness and motivation to take on new challenges in their professional work, but it seems crucial that graduates of medical faculties have the ability to use their knowledge in practice, also in new and non-standard situations.
Aim of the study. The aim of the study was to assess the impact of simulation exercises on self-efficacy according to the Bandura's theory and self-assessment of the students in the provision of education services for a diabetic patient. Study setting. The questionnaire-based study was conducted during pharmaceutical care peer role-play classes in a simulation environment with a debriefing session among 85 final year pharmacy students at Poznan University of Medical Sciences, Poland. It consisted of two surveys: General Self-Efficacy Scale (GSE) and a pre-post self-assessment and self-efficacy questionnaire.
Results. It was revealed that there is a positive correlation between GSE and self-efficacy (R = 0.52, p < 0.0001). There was also a statistically significant increase in the post-self-assessment of all the skills and competencies included in the survey in the field of pharmaceutical care of a patient with diabetes compared to the pre values (p < 0.001). Also, the students' self-efficacy regarding communication with the patient was higher than before the classes (4.85 vs. 6.26, p < 0.001).
Conclusions. The peer-role play active teaching method turned out to be a cost-effective method that allows to increase the self-assessment and self-efficacy of a pharmacy students in the diabetic patient pharmaceutical care. Further in-depth research is needed to fully confirm the effectiveness of simulation exercises in teaching pharmacy undergraduates.
Differently expressed proteins in serum on elderly patients suffered perioperative neurocognitive disorders underwent transurethral resection of prostate
Authors: Qin Yu-ming , Tang Yi-fan , Liu Ting , Xiao Qiu-Xia , Li Qiu-Yan , Liu Qing , Zhang Ying , Li Hong-Yan
Published: June 2023

Objective: Perioperative neurocognitive impairment (PND) is a common neurological complication after major operation and emergency operation in the elderly. Its pathogenesis still remains unknown. This study aims to explore new targets and prediction methods for PND occurrence.
Methods: 229 elderly patients with prostatic hyperplasia who underwent transurethral resection of prostate(TURP) combined with spinal cord and epidural analgesiawere selected as subjects and divided into PND group and non-PND group according to Z-score method. According to the principle of consistency between preoperative and intraoperative conditions, serum samples of 3 patients were randomly selected from each group. iTRAQ proteomics technology was used to screen the differentially expressed proteins in serum between the two groups. Bioinformatics analysis of the differentially expressed proteins was conducted.
Results: Among 1101 serum proteins of PND group and non-PND group, 8 differentially expressed proteins of PND patients were screened, among which 6 proteins were up-regulated and 2 proteins were down-regulated. Further bioinformatics analysis of differentially expressed proteins showed that they were mainly involved in the biological processes of cells, the formation of cell components, and the biological processes of endocytosis and phagosomes, and had the RING domain of E3 ubiquitin ligase.
Conclusion: iTRAQ proteomics screened the difference of protein molecular expression in serum between PND patients and non-PND patients, and identified 8 differentially expressed proteins. Bioinformatics analysis suggests that differential proteins are mainly involved in the biological processes of microtubules, and the study of neuroplasticity and synaptic formation based on the microtubule formation process may contribute to further understanding and prevention of PND.
Trial registration: Registered(ChiCTR2000028836).Date(20190306).
Role of macrophages in outer membrane of Chronic Subdural Hematoma
Authors: Yang Cheng , Zeng Xiangjun , Yin Jiming , Guo Song , Liu Weiming , Liu Yu
Published: June 2023

Background
Chronic subdural hematoma (CSDH) is a common disease in the field of neurosurgery. Previous studies show that the outer membrane of CSDH is divided into four histological stages by HE staining and elasticavan Gieson staining. However, this method cannot show the proportion of specific inflammatory cell components at different stages. This study aims to explore the major inflammatory cells in the outer membrane of CSDH and discussion their function in CSDH.
Methods
A total of 18 patients were included in this study. A semi-quantitative analysis was performed on the results of Hematoxylin-eosin (HE), immunohistochemistry and Masson staining.
Results
Analysis results show, in stage II, that macrophages make up the highest number of inflammatory cells, followed by T cells, B cells and neutrophil. Eosinophil main express at stage II and stage III. Interestingly, Inflammatory cells in the outer membrane are arranged in this order at any stage. In stage III, the expression number of CD31 is more than in stage II. Masson staining shows that neomembrane fibrosis gradually increases from stage I to stage IV. The expression of Transforming growth factor β(TGF-β) in the outer membrane correlates with the expression of CD68 in neomembrane (R2 = 0.810, P = 0.015).
Conclusion
The external membrane of CSDH may be a process of formation of scarring membrane according to the results of inflammatory elements in the outer membrane. The formation and development of the outer membrane of CSDH changes dynamically, macrophages play an important role in inflammation, neocapillaries and fibrosis, we considered macrophages play a critical role in the development of CSDH.
Transposition of the medial synovial flap to repair the lateral joint capsule in total knee arthroplasty for knee osteoarthritis with permanent patellar dislocation
Authors: Tao Qifeng , Liu Hongwen , Wang Hongping , Chen Chunyu , Lan Yuping , Ming Jie
Published: June 2023

Purpose
To retrospectively review the early- and medium-term clinical outcomes of lateral capsulorrhaphy by medial synovial flap transposition in total knee arthroplasty for the treatment of knee osteoarthritis with permanent dislocation of the patella.
Method
To surgically restore the patellar trajectory in 29 patients with knee osteoarthritis associated with permanent patellar dislocation undergoing total knee arthroplasty using medial synovial flap transposition to repair the lateral joint capsule. Preoperative and 2-year postoperative conditions and knee mobility were compared using the American Knee Society score function score, UCLA activity scale score, and visual analogue (VAS) pain scores. The patients were examined radiographically for full-length knee and axial patellar reduction while standing on both lower limbs.
Result
The patients' American Knee Society function scores improved from 40.2 ± 12.1 preoperatively to 80.5 ± 7.3 at 2 years postoperatively (P < 0.001), and their UCLA activity class scores improved from 3.9 ± 0.6 preoperatively to 6.8 ± 0.7 at 2 years postoperatively (P < 0.001). VAS pain scores decreased from 41.8 ± 6.0 points preoperatively to 10.1 ± 3.7 at two years postoperatively (P < 0.001). Knee mobility improved from 74.6 ± 8.9 degrees preoperatively to 110.5 ± 4.5 degrees at two years postoperatively (P < 0.001), and imaging showed no signs of subluxation or dislocation of the patella in any of the patients.
Conclusions
The correction of the patellar trajectory in patients with osteoarthritis with permanent patellar dislocation undergoing total knee arthroplasty using medial synovial flap transposition to repair the lateral joint capsule can lead to satisfactory early and medium-term clinical results.
Sex-dependent neuronal effects of α-synuclein reveal that GABAergic transmission is neuroprotective of sleep-controlling neurons
Authors: Santos Altair Brito Dos , Thaneshwaran Siganya , Ali Lara Kamal , Leguizamón César Ramón Romero , Wang Yang , Kristensen Morten Pilgaard , Langkilde Annette E. , Kohlmeier Kristi A.
Published: June 2023

Background Sleep disorders (SDs) are a symptom of the prodromal phase of neurodegenerative disorders that are mechanistically linked to the protein α-synuclein (α-syn) including Parkinson’s disease (PD). SDs during the prodromal phase could result from neurodegeneration induced in state-controlling neurons by accumulation of α-syn predominant early in the disease, and consistent with this, we reported the monomeric form of α-syn (monomeric α-syn; α-synM) caused cell death in the laterodorsal tegmental nucleus (LDT), which controls arousal as well as the sleep and wakefulness state. However, we only examined the male LDT, and since sex is considered a risk factor for the development of α-syn-related diseases including prodromal SDs, the possibility exists of sex-based differences in α-synMeffects. Accordingly, we examined the hypothesis that α-synMexerts differential effects on membrane excitability, intracellular calcium, and cell viability in the LDT of females compared to males. Methods Patch clamp electrophysiology, bulk load calcium imaging, and cell death histochemistry were used in LDT brain slices to monitor responses to α-synMand effects of GABA receptor acting agents. Results Consistent with our hypothesis, we found opposite effects of α-synMon female LDT neurons when compared to male. In the females, α-synMinduced a decrease in membrane excitability and reductions in intracellular calcium which were reliant on functional GABAergic receptors, as well as decreased the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) with a concurrent reduction in action potential firing rate. Cell viability studies showed higher α-syn-mediated neurodegeneration in males compared to females, that depended on inhibitory amino acid transmission. Further, GABA receptor agonists reduced cell death in males. Conclusions When taken together, we conclude that α-synMinduces a sex-dependent effect on LDT neurons involving a GABA receptor-mediated mechanism which is neuroprotective. Understanding the potential sex differences in neurodegenerative processes, especially those occurring early in the disease, could enable implementation of sex-based strategies to identify prodromal PD cases, and promote efforts to illuminate new directions for tailored treatment and management of PD.