bluuebunny/crossref_metadata_2025 huggingface dataset:
1 Case of Adrenal Cushing Syndrome with Multiple Bone Fractures
Authors: Yeo Sung Hee , Lee Sang Ah
Published: May 2022

There are many causes of secondary bone loss, such as immobilization, endocrine disorders, renal disease and eatingdisorders. Cushing syndrome is caused by the hypersecretion of adrenal glucocorticoids and is the common cause of bonemetabolism disorder, which results in a rapid progressive osteoporosis and vertebral compression fractures in young age.Severe metabolic bone fractures are frequently shown in iatrogenic or ectopic cushing syndrome but rare in pituitary andadrenal cushing syndrome. Because cushing syndrome was early detected by typical features in pituitary and adrenal cushingsyndrome. We report a rare case of adrenal cushing syndrome concurrent with multiple bone fractures.
Clinical Manifestations of Symptomatic Hepatic Cysts and Ethanol Sclerotherapy
Authors: Lee Jung-Hwan , Cho Yoo-Kyung , Lee Mu Suk , Kim Seung Hyoung , Song Byung-Cheol
Published: May 2022

Background : Most hepatic cysts are asymptomatic liver disease. Rarely, hepatic cysts will be symptomatic because ofincreasing size, infection and hemorrhage. We describe clinical characteristics of symptomatic hepatic cysts and its effectivetreatment.Methods : We performed a retrospective review of all patients diagnosed with symptomatic hepatic cysts between May 2009and April 2013 in Jeju National University Hospital. Twenty one symptomatic hepatic cysts (mean 10.7cm) in 14 patients (12women and 2 men, aged 51 to 81 years) were enrolled.Results : Symptoms of hepatic cysts were right upper abdominal pain (10 patients), recurrent lower extremities edema (2patients), fever (3 patients), and right shoulder radiating pain (1 patient). All symptomatic hepatic cysts were treated withpercutaneous drainage (mean volume 480 ± 325 ml, max 1250 ml). Three infected cysts were diagnosed by cystic fluidanalyses and treated using antibiotics. After drainage, 20 hepatic cysts were treated with 99.9% ethanol sclerotherapy for threedays. There were few minor complications including pain, nausea, vomiting. During follow-up (11 months), there was norecurrence. The mean diameter of remained cysts decreased to 3.2 cm with an average volume reduction rate of 92.3 % (from464.1 cm3 to 35.8 cm3).Conclusions : Percutaneous drainage and ethanol sclerotherapy is a very effective and safety treatment method ofsymptomatic hepatic cysts.
Inflammatory Pseudotumor of the Liver that Mimicked Hepatocellular Carcinoma
Authors: Hyun Jong-Hoon , Hyun Chang-Lim , Cho Yoo-Kyung
Published: May 2022

Inflammatory pseudotumor is a tumor-like lesion characterized by chronic inflammatory cell infiltration with fibrosis.Inflammatory pseudotumor of liver has nonspecific symptoms including right abdominal discomfort, fever, and weight loss.Therefore it is very difficult to differential diagnosis from other malignant liver tumor. Herein, we report the case of a 75-yearoldmale with a solitary hepatic mass, who was initially considered with hepatocellular carcinoma by computed tomography (CT).The patient was diagnosed with hepatic inflammatory pseudotumor by pathologic confirm.
A Case Report about Doubting a Miscondition of Publication by a Third Party based on the
Confusing Ownership of Databases
Authors: Bae Jong-Myon
Published: May 2022

A case of publication misconduct by a third party was recognized during some activities of academic consultations. The thirdresearchers (TR) obtained a raw database (RDB) by an illegal way and presented the results in an academic conference withoutpermission of original researchers (OR) who constructed RDB. In addition, TR has awarded a contract without discussion withOR. The aim of contract is to re-verify the results of OR using the RDB, but OR already published the results in an international,peer-reviewed medical journal. Consequently, TR has unwillingly made author doubt the misconducting publication ethics suchas authorship, falsification, and plagiarism, as well as copyright infringement. This case let academic societies alarm tocomplement the rules about ownership of RDB. A good rule of thumb is to discuss with OR under keeping scientific ethicsbefore using the RDB.
Effect of rutin on the accumulation of lipid in H4ⅡE hepatoma cells
Authors: Lee Ho-Won , Park Deok-Bae
Published: May 2022

Rutin is a flavonoid compound present within various plants. Previous studies have suggested that rutin has a potential antidiabeticand a anti-cancer activity in a few experimental models. However, it is uncertain that rutin can affect hepatic lipidaccumulation, which is a pathophysiological marker of steatohepatitis (fatty liver) in metabolic syndrome. The present studyinvestigated the effect of rutin on the intracellular accumulation of lipid induced by palmitic acid in H4IIE rat hepatoma cells.Rutin significantly suppressed palmitic acid-induced lipid accumulation whereas other flavonoid compound (hesperidin) did not.Protein content of the key enzyme in the biosynthesis of triglyceride, FAS, was decreased by rutin. The number of intracellularlipid droplets was also suppressed by rutin. Taken together, rutin has a strong anti-lipogenic activity, indicating thepharmacological potential to treat one of metabolic syndrome.
Problem based-learning experience in the neurological disease
Authors: Chung You-Nam
Published: May 2022

In this study, we report for the survey of the PBL experience , students trained by experienced nervous system disordersusing the Medical School developed a module on the basis of neurological disorders in the second year of a targetedenforcement PBL.
Neuroprotective effects of Sasa quelpaertensis leaf extract against microglia-mediated neurotoxicity
Authors: Lee Ji Hyung , Park Jee-Yun , Cui Yan Ji , Kim Se-Jae , Park Joo Min , Jung Sung-Cherl , Eun Su-Yong
Published: May 2022

Sasa quelpaertensis leaf extract (SQE) has shown various biological effects in several tissues. However, the pharmacologicaleffect of SQE has never been investigated yet in the central nervous system. Therefore, we investigated whether the hot waterextract from Sasa quelpaertensis Nakai suppresses lipopolysaccharide (LPS, 100 ng/ml)-induced microglial activation. Theresults demonstrated that SQE significantly reduced NO production in LPS-stimulated BV-2 microglial cells. In addition, SQEshowed free radical scavenging activity in DPPH assay. Taken together, these results suggest that SQE may have a therapeuticpotential against neuroinflammation and neurodegeneration through suppression of excess microglial activation-mediatedneuronal cell death.
Usability of the FLAIR Image in Temporal Lobe Epilepsy
Authors: Ki Yage Tae
Published: May 2022

It is necessary to identify the epileptogenic zone in patients with intractable epilepsy. It is, however, difficult to identify thelesion in conventional MRI including T1WI and T2WI. Another pulse sequence, FLAIR (Fluid-attenuated inversion recovery) image,may give a clue to identify the epileptogenic lesion in MRI. This study included 20 patients, who did not show discrete unilateralhippocampal atrophy or sclerosis, and who showed unilateral hippoccampal atrophy and contralateral sclerosis in T1WI or T2WI.Preoperatively, all patients had chronic video-EEG (Electroencephalography) monitoring with standard surface electrodes anddepth electrodes in bilateral hippocampus. Standard anterior temporal lobectomy was performed in 17 patients, and selectiveamygdalohippocampectomy was done in three. MRI including T1WI and T2WI recognized unilateral hippocampal atrophy andsclerosis in three, unilateral hippocampal atrophy and contralateral hippocampal sclerosis in three. The rest of the patients didnot show any identifiable lesion in MRI. FLAIR image, however, identified high signal intensity of the unilateral hippocampus in12, bilateral hippocampus in three, and showed none of change in five. Anterior temporal lobectomy was performed based onthe data of the MRI with FLAIR image and depth EEGs. Histopathologic findings revealed hippocampal sclerosis in all. 18patients were seizure free at the follow-up period of 16- 28 months. In patients with intractable temporal lobe epilepsy whohad difficulty in lateralizing the epileptogenic temporal lobe in semiology, surface EEG, and the conventional MRI including T1WIand T2WI, FLAIR image is of value in identifying the epileptoge nic hippocampus.
Therapeutic Embolization for Postoperative Hemorrhage of Lateral Inferior Genicular Artery after Total Knee Arthroplasty : A Case Report
Authors: Kim Sang-Rim , Park Yong-Geun
Published: May 2022

We describe a case of 67-year-old man who had a hemorrhage of the lateral inferior genicular artery after total kneearthroplasty. The authors encountered rare case of a pseudoaneurysm that was occurred due to the genicular artery injuryduring the knee arthroplasty operation. The pseudoaneurysm was treated successfully without the need for surgicalintervention using transcatheter embolization. No recurrence of the hemarthrosis was observed in the patient after a follow-upof 2 years.
Presumed IgG4-Related Disease Presented as Coronary Periateritis: A Case Report Showing Dramatic Response to Steroid Therapy
Authors: Kim Jeong Jae , Kim Song Yi , Jeong Sun Young , Kim Seung Hyung , Hwang Im Kyung
Published: May 2022

A 54-year-old man underwent a coronary computed tomographic (CT) angiogram for a health check-up, and a soft tissuemass surrounding the right coronary artery was observed in the right atrioventricular groove. Moderate degree of multifocalstenoses were also noted in the left coronary artery. The serum concentration of immunoglobulin G4 was significantly increasedat 1569 mg/dl. In suspicion of IgG4-related periarteritis, he was treated with steroids. Two months after steroid therapy,coronary CT angiography revealed interval improvement of coronary periarteritis.
A patient with Crohn's disease in remission after azathioprine induced severe myelosuppression
Authors: Boo Sun-Jin , Choi Eun Kwang
Published: May 2022

Azathioprine (AZA) is widely used to maintain clinical remission of Crohn’s disease. AZA is also important as a steroidsparingagent in steroid-dependent and active Crohn’s disease. Bone marrow suppression is common adverse effect ofAZA. We report a case of a 16-year-old male patient who was diagnosed as Crohn’s disease with involvement of terminalileum and colon; he experienced clinical and endoscopic remission of Crohn’s disease following improvement of AZAinduced life-threatening myelosuppression and pancreatitis.
Relation between visceral & subcutaneous abdominal fat area and insulin sensitivity indices
Authors: Kim Ji Hyon , Moon Ji Hyeon , Kim Hyeon Ju , Kong Mi Hee
Published: May 2022

Obesity is associated with complications such as hyperlipidemia, hyperinsulinemia, hypertension and cardiovasculardiseases. We studied the relation of visceral & subcutaneous abdominal fat area and insulin sensitivity indices in nondiabeticsKorean adults. This is a cross-sectional study by 204 patients who visited a Health Promotion Center of onehospital. We analyzed the association of anthropometry(waist circumference, BMI), visceral & subcutaneous fat by abdominalfat CT, insulin sensitivity or resistance indices(HOMA-IR, QUICKI, 1/insulin, Glucose/insulin), and plasma concentrations oflipid profiles. We found that in men, VFA and VSR have a negative correlation with Insulin sensitivity indices(QUICKI, 1/fastinginsulin, G/I ratio) and a positive correlation with cholesterol and HOMA-IR. In women, we found that VFA and VSR have anegative correlation with HDL-cholesterol and QUICKI and positive correlation with triglyceride and HOMA-IR. After adjustedfor age, BMI and waist circumference, we found that only in men, VFA and VSR have a negative correlation with Insulinsensitivity index(QUICKI, 1/fasting insulin, G/I ratio). As shown above, in men, Visceral fat & visceral fat/subcutaneous fatratio are related strongly to Insulin resistance and sensitiviyt index.
ICU scoring system, SAPS 3
Authors: Yun So Hui , Park Jong Cook
Published: May 2022

The scoring systems used widely in the field of intensive care are prognostic models that estimate the in hospital mortalityrate. Many clinicians utilize these systems to measure the severity of illness, predict patient prognosis, and gatherinformation for clinical research. We introduce the SAPS (Simplified Acute Physiology Score) 3 system that one of thesescoring system.
Peptide hormone exendin-4 enhances neurogenesis in the dentate gyrus of photochemically induced cerebral ischemia model mice
Authors: Lee Chang Sub
Published: May 2022

Exendin-4 is a peptide resembling GLP-1 (glucagon-like-peptide 1) in the saliva of the glia monster, a poisonous lizard.Recently, exendin-4 has been reported that stimulates subventricular zone neurogenesis in the adult rodent brain. The authortrying to evaluate the effects of exendin-4 on the neurogenesis in the hippocampus of photochemically induced cerebralischemia model mice. Eight week-old male C57/BL6 mice were used. First, rose Bengal was injected via tail vein. After scalpincision, photothrombic lesion was made on right motor cortex with cool light radiation through optic fiber. Behavior test(adhesive-tape test) was performed to verify the appropriate brain injury. Daily injection of exendin-4 for 7 days was followed.Saline was injected in sham operation group. After 3 weeks of holiday, decapitation was performed. Exendin-4 treatment forone week significantly increases numbers of Ki-67 and BrdU immunoreactive cells in the hippocampus of ischemic model mice.The present study shows that exendin-4 is able to induce proliferation and differentiation in vivo of neural stem cells form theadult dentate gyrus and indicates a role for exendin-4 as modulator of neurogenesis of adult brain.
The Effects of the Hand Hygiene Initiative on Hand Hygiene Compliance and Nosocomial Infection Rate: an Experience in a Single Center Surgical ICU
Authors: Lee Chang Sub , Kim Min Soo , Kang Young Joon
Published: May 2022

Background: Between 5~10% of hospitalized patients in developed nations are affected with nosocomial infections (NCIs), therates are even higher among intensive care unit (ICU) patients. Robust evidence suggests that proper hand hygiene has anessential role in the prevention of NCIs. However, in despite of the overwhelming evidence, hand hygiene compliance amonghealth care providers (HCPs) was lower than expected. This study was performed to evaluate the impacts of the Hand HygieneInitiative (HHI) on compliance of hand hygiene and the rate ofN CI in a single center surgical ICU.Methods: All HCPs (physicians, nurses, radiographers and physical therapists) who had accessed the Jeju National UniversityHospital (JNUH) Surgical ICU were the subjects of this study. The HHI composed of five activities: lectures, monitoring of handhygiene compliance, complement facilities, encouraging handrubs use and abiding by the rules concerning isolated patients.Surveillances of NCI rates and hand hygiene compliances before and during the activities were monitored by the "InfectionControl Committee of JNUH".Results: Hand hygiene compliance improved from 74.0% before the activities to 89.4% during the activities (p<0.0001).Overallinfection rate ofJ NUH-SICU decreased from 5.98 to 3.98 per 1,00 patient-days which was not statistically significant (p=0.38).Conclusions: Hand hygiene compliance was improved by HHI, but further efforts will be needed to maintain this impact. HHIdiminished the NCI rate in a single institute surgical ICU, but following studies will be needed to assess whether theimprovement was statistically significant.
Hobnail hemangioma: differential diagnosis of vascular tumors with similar
histopathologic findings
Authors: Park Seulgee , Cheon Minseok , Kim Jae-Wang
Published: May 2022

Hobnail hemangioma(targetoid hemosiderotic hemangiomas) is a benign vascular tumor characterized histologically by abiphasic growth pattern of dilated vascular channels in the superficial dermis lined by prominent hobnail cells and rather narrowneoplastic vessels in deeper dermis. This tumor affects mainly the lower limbs or trunk of male adult. Histopathologically, hobnailhemangioma should be differentiated from a variety of benign to malignant vascular tumors. Herein, we represent a case ofhobnail hemangioma which had been confirmed through the skin biopsy.
Unusual encrusted cystitis by Escherichia Coli(Case Report)
Authors: Lee Yeong Geun , Park Kyungkgi , Kim Sung Dae , Kim Young-Joo , Hyun Chang Lim , Huh Jung Sik
Published: May 2022

Bladder calculi have been observed in men with urinary stasis. Especially, bladder calculi induced irritative voiding symptomssuch as frequency, nocturia, and obstructive voiding symptoms such as hesitancy, post ?voiding dribbling . We report anunusual case of 64-year-old male with soft bladder stone and will briefly discuss the management.
Ultrasonographic findings of median nerve according to the change
of the wrist positions
Authors: Han Eun Young , Im Sang Hee
Published: May 2022

Objectives : To assess the changes of ultrasonographic findings of median nerve according to the change of wrist positionsin normal adults.Methods : We studied 26 normal hands using musculoskeletal ultrasonography. A cross-sectional area, antero-posteriordiameter, transverse diameter and a flattening ratio of median nerve were measured in neutral, in 30 degree of flexion and in30 degree of extension positions of the wrist.Results : The cross-sectional area of median nerve was significantly increased on the wrist flexion (P<0.05), compared to thatof the neutral position. The flattening ratio of median nerve was significantly decreased in the position of wrist flexion (P<0.05),but significantly increased in the position of wrist extension (P<0.05), compared to that of the neutral position.Conclusion : Ultrasonography of median nerve showed structural changes according to the changes of the wrist position innormal adults. Further large-scaled studies comparing healthy controls with the patients with carpal tunnel syndrome ranging ofage are mandatory to reveal the mechanical effects of wrist position on median nerve.
A rare case of idiopathic central precocious puberty in a 17-month-old girl
Authors: Kim Chae-Ho , Shin Kyung-Sue
Published: May 2022

Central precocious puberty (CPP) is defined as development of secondary sex characteristics in relation with activationof the HPG axis before the age of 8 years in girls and before the age of 9 years in boys. CPP is far less common inchildren before 3 years of age, particularly in females. Most girls with signs of puberty less than 3 years of age arediagnosed with premature thelarche (PT). Although CPP presenting with early breast development should be differentiatedfrom PT, there is no diagnostic method which would definitely differentiate these two conditions. We present idiopathicCPP before 3 years of age who presented with PT that rapidly progressed to CPP. Up to date, there are no predictiveclinical or laboratory tests that can identify the risk of progression to PP at time of onset. Therefore, all girls with PTshould be monitored clinically for accelerated pubertal progression.
Intravenous immunoglobulins in neurological diseases
Authors: Kang Sa-Yoon
Published: May 2022

Intravenous immunoglobulin (IVIg) has been used for nearly three decades, and is proving to be an efficient anti-inflammatoryand immunomodulatory treatment for a number of neurological diseases. Evidence from randomized controlled clinical trials hasestablished IVIg as a first-line therapy for chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, andmultifocal motor neuropathy and the efficacy and safety of IVIg treatment have been summarized in Cochrane systemic reviews.Reports about successful IVIg treatment in other neurological condition exist, but its use remains investigational. IVIg is aneffective rescue therapy in exacerbations of myasthenia gravis and is beneficial as a second-line therapy for dermatomyositisand stiff-person syndrome. IVIg has been tested in some neurodegenerative diseases, but a controlled study in Alzheimerdisease yielded disappointing results. Despite its widespread use and therapeutic success, the mechanisms of action of IVIg arepoorly understood. In addition, questions remain regarding the dose, timing and duration of IVIg treatment in neurologicaldiseases. This review highlights emerging data on the mechanisms of action of IVIg and practical guidelines on administration ofIVIg in diverse neurological diseases.
Cardiac Rehabilitation in Patients with Left Ventricular Assistive Device (LVAD)
Authors: Kim Bo Ryun , Lee Seog Jae , Han Eun Young
Published: May 2022

For severe heart failure patients who are refractory to medical treatments or who are unable to receive heart transplantationbecause of a shortage of donor organs, left ventricular assist device (LVAD) therapy could be a valuable option as not onlybridge to transplantation but also destination therapy. The LVAD can substitute the circulatory function of one or both sides ofthe heart via several pump drive mechanisms. The native left ventricle-LVAD complex responds physiologically anddemonstrates a significant circulatory reserve consistent with the capability to meet demands of daily activities. Althougthseveral studies have suggested that LVAD patients showed a significant improvement in physical function, exercise capacityand quality of life, early initiation of cardiac rehabilitation should be needed to facilitate improvements in functionalindependence and survival rate in LVAD patients. To date, unfortunately, exercise training in LVAD patients is in its infancy, andevidence on content, setting, duration of the sessions and safety are inconclusive. Therefore, the further development of variouscardiac rehabilitation programs for LVAD patients through ongoing controlled exercise training trials would be warranted.
Rehabilitative Applications of Aquatic Exercise
Authors: Kim Bo Ryun
Published: May 2022

Exercise in warm water, usually called aquatic exercise or hydrotherapy is a popular treatment for many patients withneurologic or musculoskeletal diseases. Aquatic exercise utilizes the property of water such as the warmth, buoyancy, andhydrostatic effects for relieving pain and improving strength, endurance, cardiovascular fitness in these patients. There weresome evidences demonstrating the effectiveness of aquatic exercise on pain, activity of daily living, locomotion, strength inpatients with various rehabilitative diseases including arthritis, stroke, cerebral palsy, multiple sclerosis, back pain, elderly,fibromyalgia. However, there.
Pyoderma gangrenosum : two case reports
Authors: Lee Ji-Na , Kim Jae-Wang
Published: May 2022

Pyoderma gangrenosum is a rare, often destructive, neutrophilic dermatosis characterized by painful, necrotic superficialulceration, central suppurative exudate and a peripheral undermined border. Five clinical variants are recently recognized asfollows: classic(ulcerative), bullous, pustular, vegetative and peristomal types. Pyoderma gangrenosum is often a diagnosis ofexclusion, as there are no specific laboratory or histopathologic findings to confirm the diagnosis. Accordingly, it is difficult todiagnose, and often requires a work-up for underlying systemic diseases. Mimickers include infection, vascular insufficiency,systemic vasculitides, autoimmune disease, skin cancer or exogenous tissue injury. Herein, we present two cases of ulcerativepyoderma gangrenosum occurring on the legs, along with a comprehensive review.
15-year old man patient with renal coloboma syndrome caused by PAX2mutation
Authors: Lee Yeo Jin , Lee Hye Jin , Cheong Hae Il , Han Kyoung Hee
Published: May 2022

Renal coloboma syndrome (RCS) is characterized by renal hypoplasia and optic disc coloboma. RCS is an autosomaldominant inherited disorder caused by PAX2 gene mutations. We report a case of RCS caused by PAX2 gene mutation in a15-year-old man.
Comparison between standards of medical school accreditation of World Federation for
Medical Education and Korean Institute of Medical Education and Evaluation
Authors: Yoo Hyo Hyun , Huh Jung-Sik , Kim Mi Kyung , Yoon Hee Sang , Lee Kang Wook , Lee Jong-Tae , Hong Seung-Jae
Published: May 2022

7Division of Rheumatology, Department of Internal Medicine, KyungHee University Medical Center, KyungHee University, Seoul, Korea.Medical school is the core of medical education to teach students. Medical school has a educational programmes under adifferent environment. Evaluation of medical school undertakes to promote the highest scientific and ethical standards in medicaleducation, initiating new learning methods, new instructional tools, and innovative management of medical education. We findout the differences compared the standards of WFME and KIMEE.World Federation for Medical Education(WFME) is an accrediting agency charged with quality improvement in the medicaleducation in the world. The WFME recommends global standards, which are structured to 9 areas with a total of 36sub-area inthe medical education. 9 Areas are mission and objectives, educational programme, assessment of students, students, academicstaff/faculty, educational resources, programme evaluation, governance and administration, continuous renewal. Sub-areas aredefined as specific aspects of an area, corresponding to performance indicators including basic standard and standard forquality development. Korean Institute of Medical Education and Evaluation (KIMEE) evaluates the 'Basic Medical ScienceCurriculum' in medical schools in Korea. The KIMEE recommends standards, which are structured to 6 domain with a total of 97sub-domain in the medical education. 6 domains are operating system, basic medical curriculum, student, faculty, facilities&equipments, and post-graduation. KIMEE has developed 97 global standards for appraisal of basic medical education. Bothinstitutions have the common standards to improve basic medical education and undertakes to promote the high scientific andethic standards in medical education. Modification of the WFME standards according to our country reality will be validity andobjective..
A Case of Intramuscular Lipoma of Tongue with Ulcer and Pain
Authors: Hyun Chang Lim , Song Chan Il
Published: May 2022

Although Lipomas are one of the most common benign tumors, intramuscular lipomas of tongue are quite rare. Lipomas oftongue are represented by less than 0.5% of all benign tumors in the oral cavity. Oral cavity lipomas are usually growing slowly,painless and asymptomatic before they reach large sizes. When they are ulcerated, they present diagnostic problems. Wereported a case of intramuscular lipoma of tongue with ulcer and pain.
Beauveria bassiana Causing Keratoscleritis In a Patient with Adrenal Insufficiency
Authors: Kim Jin Ho , Kim Young Ree , Kim Sun Hyung , Jung Jin Ho , Lee Sang Woon
Published: May 2022

The Beauveria species, well-known insect pathogens, have been used for biological insecticides. They were increasinglyreported to cause human infections in worldwide, such as mycotic keratitis, disseminated infection in a patient with acuteleukemia, and deep tissue infection. We introduce here a case of keratoscleritis due to the Beauveria bassiana in animmunocompromised patient with underlying adrenal insufficiency, degenerative arthiritis, and hypertension, initially notsuspected by SDA and LPCB stain and revealed by PCR and 18S rDNA sequencing as the Beauveria species
Roseomonas gilardii Bacteremia from a Peripherally Inserted Central Catheter in a
Patient with Endometrial Cancer
Authors: Yang Dong Chul , Kim Young Ree , Kang Sung Ha , Kwon Jung Mi
Published: May 2022

Roseomonas gilardii, a Gram-negative, non-motile, non-spore-forming, strictly aerobic, and pink-pigmented coccobacillus, isan uncommon species causing human infection. But, occasionally, it has been reported as a causative organism of opportunisticinfection in some countries. We report a case of bacteremia in a 51-year-old woman with endometrial cancer. She visited ouroutpatient clinic, complaining of cough, headache, and febrile sensation for 3 days after palliative chemotherapy performed 8days earlier. Cultures of the blood and the peripherally inserted central catheter were performed and bacteria were isolatedfrom cultures after 5 day incubation. Microbiological tests such as Gram staining, culture, and identification testing revealedRoseomonas gilardii. The patient was treated with antibiotics for 9 days and discharged. This case of Roseomonas gilardiibacteremia from the peripherally inserted central catheter in a patient with endometrial cancer suggests the importance ofdiagnostic tools for accurate identification of unusual causative organisms of bacteremia in immunocompromised patients.
The Etiology of Respiratory Viral Infection in Children in Jeju Island
Authors: Kim Yoon Joo , Kim Young Ree , Choi Jae Hong
Published: May 2022

Viral etiology of respiratory tract infections in hospitalized children was investigated from April 2014 to March 2016 inJeju Island. The etiology of respiratory viral infection in Jeju Island wasnot different from that of mainland Korea.
Type A lymphomatoid papulosis: subclassification of lymphomatoid papulosis and
histopathologic differential diagnosis of anaplastic large cell lymphoma
Authors: Mun Gawon , Kim Jae-Wang
Published: May 2022

Lymphomatoid papulosis is a chronic self-regressing papulonecrotic or papulonodular skin disease with histologicfeatures suggestive of a malignant lymphoma. It is part of a spectrum of CD30-positive cutaneous lymphoproliferativediseases, is considered as one of indolent cutaneous T-cell lymphomas. The disease is characterized by recurrentcrops of pruritic papules at different stages of development that predominantly arise on the trunk and proximalextremities. Clinicopathologically, lymphomatoid papulosis should be differentiated from anaplastic large cell lymphoma.Continued observation of all patients is essential because lymphomas develop in 20% of the patients with lymphomatoidpapulosis. Herein, we present two cases of type A lymphomatoid papulosis proven by the histopathologic examination.
F-FDG PET/CT Detects Late-onset Sialadenitis After Radioiodine Ablation Therapy
Authors: Lee Jin Ho , Koh Gwanpyo , Song Heesung
Published: May 2022

Sialadenitis is a common complication arising from radioactive iodine therapy. F-18-fluoro-2-deoxyglucose positronemission tomography/computed tomography (18F-FDGPET/CT) has been proposed to be useful in detecting not only amalignant lesion but also inflammatory changes. An 18F-FDG uptake pattern can vary according to inflammatorychanges, and the present study reports on a case of late-onset sialadenitis 3 years after the treatment, showing adiffuse and intense 18F-FDGuptakeon 18F-FDGPET/CT. To the best of our knowledge, this is the first report on such an18F-FDG pattern in late-onset sialadenitis after radioiodine therapy.
Prevalence and Clinical Characteristics of Gallbladder Polyp in Jeju
Authors: Song Seung Eun , Moon Ji Hyun , Kong Mi Hee , Kim Hyeon Ju
Published: May 2022

Background: Gallbladder polyps are now increasingly detected by ultrasonography. There are many studies reporting theprevalence of gallbladder polyp, however there is no report in Jeju island. The purpose of this study is to research prevalenceand clinical characteristics of gallbladder polyps in adults living in Jeju island.Methods: We have evaluated 3,471 populations who underwent abdominal ultrasonography for health screening examinationat Jeju National University Hospital in Jeju, Korea from January 2011 to June 2012.Results: Prevalence of gallbladder polyp in Jeju island is 10.1%. Prevalence in males is 11.6% and that in females is8.2%(P<0.001). The size of gallbladder polyps mostly are less than 5mm in diameter. 216 subjects (61.5%) have single polypand 135(38.5%) subjects have multiple gallbladder polyps which means 2 or more polyps.Conclusions: The prevalence of gallbladder polyp in Jeju island has found to be higher than the pre-existing reports and theprevalence is higher in males than females. Most polyps are small and single.
Clinical approach of botulinum toxin A (Botoxⓡ) of treatment for patients
with overactive bladder
Authors: Kim Kyung Hoe , Huh Jung-Sik , Kim Young Joo , Park Kyung kgi , Kim Sung Dae
Published: May 2022

Candidates for botulinum toxin A are generally patients with overactive bladder(OAB) whose disease is in adequatelycontrolled with behavioral therapy and oral medication. All patients must be willing and able to perform cleanintermittent catheterization(CIC). Before the decision to administer botulinum toxin A is made, the clinician shouldprovide counseling to the patient regarding the agent’s indications, proposed benefis, risks, and mode ofadministration. The patient should be aware that botulinum toxin A takes effect after approximately 1?2weeks andusually lasts for 4?10months, after which repeat injections will be necessary to maintain effect. Patient preparation mayinclude pre-treatment antibiotics and withdrawal of antiplatelet therapy or anticoagulants. Preparation of the productinvolves reconstitution in sterile saline and dilution according to the planned dose. The injections are performed using aflxible or rigid cystoscope, and the procedure takes approximately 15 min. The initial follow-up visit occurs within 7?14days, when evidence of adverse effects, including urinary retention, can be evaluated. Repeat injections can bescheduled as needed, but not sooner than 3 months. Currently, the total dose of botulinum toxin A should not exceed360 U in a 3-month period for all indications, including those outside the urinary tract (i.e.,cosmetic,ophthalmologic,etc.). Overall, botulinum toxin A is effective, generally well tolerated, safe, and is relatively simple toprovide.
A Case of Gastromalacia
Authors: Kim Seong Mi , Kim Sang Hun , Kang Hyun Wook
Published: May 2022

Gastromalacia is a postmortem dissolution due to autodigestion of the gastric wall. It usually occurs in the area of the gastricfundus and may lead to gastric perforation. This rupture may also lead to pneumoperitoneum or pneumothorax. Suchpostmortem changes were stated by radiologists as gastro-intestinal perforation caused by antemortem pathology, includinginflicted trauma. It also can confuse pathologists with insufficient forensic experience and even lead to a miscarriage of justice.In this report, we will introduce a case of full-blown gastromalacia with its typical autopsy findings.
Infected Cardiac Myxoma Presenting as an Acute Stroke in the Emergency Department
Authors: Park Hyun-Soo
Published: May 2022

The intra-cardiac mass is observed in 0.05 percent of routine postmortem examinations. The difference diagnosis includesbenign, malignant primary, secondary metastatic cardiac tumor, or thrombus. Myxomas is the most common primary cardiactumors. The clinical features of myxomas are determined by their location, size, and mobility. Most patients present with one ormore of the triad of embolism, intra-cardiac obstruction and constitutional symptoms. We present a 65-year-old man whovisited the emergency department, complaining of sudden onset dysarthria and right side weakness. After initial brain image, hewas diagnosed with acute stroke, however hypotension and elevated inflammatory marker were observed. He underwentemergent echocardiography, and 2 * 2 cm sized cardiac myxoma in his left atrium was detected.
Rhabdomyolysis as a complication of carbon monoxide poisoning
Authors: Kim Min-Ju , Kang Sa-Yoon
Published: May 2022

Carbon monoxide (CO), a highly toxic gas produced by incomplete combustion of hydrocarbon, is a relatively common causeof human injury. When the exposure history is absent, or delayed, the diagnosis is difficult. A 66-year-old woman, who use thebriquette boiler in home, presented with rhabdomyolysis. Diffusion-weighted MRI showed high signal intensities in globuspallidus bilaterally. Her symptoms and high creatine kinase level were improved by conservative management. Our case reportshows that the prognosis of CO poisoned patient greatly depends on timely and appropriate treatment, severity of damage toother organs, and success of the treatment of complications.
Applications of convolution to intravenous anesthetics
Authors: Park Jong Cook
Published: May 2022

Modern medicine has made remarkable progress with engineering. Computed tomography is a diagnostic tool that uses digitalsignal processing technology. Understanding the basic principles of medical devices that are widely used in modern medicineby clinicians can improve the accuracy of care and patient safety.Intravenous anesthetic agents induce respiratory depression and cardiovascular complications, so its administration requiresprofessional training. Target controlled infusion (TCI) is a device developed to administer intravenous anesthetics relativelysafely. This device is a device that applies the pharmacokinetic / pharmacokinetic principle.This paper reviews the literature on pharmacokinetic concepts and applications of convolution for administration ofintravenous anesthetics.
A Case of Cystic lymphangioma Children with abdominal pain
Authors: Chu Yongyeon , Kang Youngjoon
Published: May 2022

Cystic lymphangioma is an uncommon benign tumor that appears in organ with a many number of lymphatics, and rarelydevelops in the abdomen. It occurs in all ages, especially children. When it occurs in the mesentery, it called mesenterylymphatics malformation. It causes abdominal pain, abdominal distension, vomiting and constipation. If the cystic lymphangiomapresents with symptoms, surgical excision is required for treatment and diagnosis. In this report, we describe a case of cysticlymphangioma that presented with a small bowel volvulus in a 5-year-old girl visiting emergency room. At first, we suspectedacute appendicitis for her symptoms. After that, ultrasonography and computerized tomography show findings of a cysticlymphangioma. It presents symptom suspected volvulus. So operation was performed.
The combination therapy with extracorporeal membrane oxygenation,
plasmapheresis and continuous renal replacement therapy for massive
diffuse alveolar hemorrhage in a child with systemic lupus erythematosus
Authors: Kim Su Wan , Han Kyoung Hee
Published: May 2022

Diffuse alveolar hemorrhage (DAH) is a rare and life-threatening complication in children with systemic lupus erythematosus(SLE). Despite recent advances in medical therapy, DAH could drive into catastrophic respiratory failure and hemodynamicunstability. The authors present a case of a 9-year-old girl with lupus nephritis who had rapidly aggravating dyspnea andmassive pulmonary hemorrhage. She was diagnosed as having DAH with acute respiratory distress syndrome and wassuccessfully managed with combined treatment of venovenous extracorporeal membrane oxygenation (ECMO), plasmapheresis,and continuous renal replacement therapy (CRRT). We propose to introduce ECMO and plasmapheresisas early as possible as arescue therapy in children with SLE complicated to DAH, who are irresponsive to conventional treatment.
Status of National Notifiable Infectious Diseases in Jejudo, Korea: 2001-2017
Authors: Kim Mi Na , Han Yu-Jung , Yang Don Haeng , Bae Jong-Myon
Published: May 2022

Objective: Jejudo has unique geographical and climatologic characteristics compared with other areas in Korea. The aim wasto evaluate differences of the nationwide notifiable infectious diseases (NND) occurred in Jejudo.Methods : The source of data was on the Infectious Disease Statistics System operated by Centers for Diseases Control &Prevention in Koreq between 1 January 2001 and 30 September 2017. After calculating the proportion of sum of yearsshowing a higher incidence in Jejudo than nationwide divided by sum of comparing years (PSYH), authors defined the infectiousdiseases for control in Jejudo (IDCJ) with PSYH over 75%. In addition, the infectious diseases showing increasing trends duringrecent 2 years (2015-2017) were defined as sudden increase Infectious Diseases for Control (SIDCJ).Results: IDCJ in 2001-2017 included 3 NNDs such as chicken pox, syphilis, and severe fever with thrombocytopenia syndrm.And SIDCJ contained 2 NNDs such as pneumococcal infection and scarlet fever.Conclusions: The results support main evidences to plan strategies and distribute community resources for control andprevention of NNDs in Jejudo, Korea, 2018.
Ultrasound-guided lower extremity nerve block to facilitate the closed reduction of a
dislocated hip prosthesisin Geriatric Patient
Authors: Kim Jong Bin , Cho Suk Ju
Published: May 2022

Hip dislocation constitutes an orthopaedic emergency.Prosthetic hip dislocation is an unfortunate complication for patients whohave previously undergone total hip arthroplasty.A 75-year-old female was scheduled for the closed reduction of hipdislocation which occurred 12hours ago by the accident. We performed combined nerve blocks (femoral, lateral femoralcutaneous) with 20 ml of 0.25% ropivacaine with intravenous sedation for the closed reduction of righthip joint. The procedurewas performed uneventfully and the patient was kept stable hemodynamically.
Infective Endocarditis Presented with Septic Sacroiliitis
Authors: Jeong Woo Seong , Yoo Jeong Rae , Heo Sang Taek
Published: May 2022

A 19-year-old girl presented to our hospital with right hip pain, fever, and weight loss for 4 weeks. Initial laboratory findingsshowed an elevated C-reactive protein (3.61 mg/L) and a positive rheumatoid factor. Arthritis on the both scaroiliac joints wasrevealed on three phase bone scan. She had treated with antibiotics for septic sacroiliitis. Penicillin susceptible Streptococcussanguinis was isolated from blood cultures. A transesophaseal echocardiography showed a vegetation on the mitral valve, whichconfirmed our diagnosis of infective endocarditis. She was treated with penicillin G and gentamicin with a total duration oftreatment of 4 weeks. This report showed a rare septic sacroiliitis complicated by infective endocarditis caused by viridansstreptococcus. Although, sacroilitis is an important component of inflammatory spondyloarthropathy, infective endocarditis wouldbe evaluated in case of a septic arthritis.
Metronidazole Induced Hypoglycemia on an Elderly Patient without Diabetes
Authors: Park Jun Hyun , Lee Sang Ah
Published: May 2022

In the elderly, diabetes patients often experienced hypoglycemia due to medication. However, hypoglycemia can occur in awide variety of situations without diabetes such as these cases including heavy alcohol drinking, decreased liver function,sepsis, pneumonia, and decreased renal function, etc. In this case, hypoglycemia occurred in treating with cefotaxime andmetronidazole in patients with abdominal pain due to intravascular embolism at the entrance of the superior mesenteric artery.This hypoglycemia was accompanied by hyperinsulinemia. The possibility of other adrenal insufficiency was excluded becauseof normal response in rapid ACTH test. Insulinoma was also excluded because of no experience of hypoglycemia beforeadmission and no tumor in pancreas in CT scan. In addition, renal function was recovering, so renal function was unlikely to bea cause.We doubt the possibility of antimicrobial agents,cefotaxime and metronidazole, as a cause of hypoglycemia. Firstly, westopped cefotaxime, but continued hypoglycemia until day 3. And, as the next step, we quit the use of metronidazole and thenhypoglycemia was recovered. In this case, we suggested that hypoglycemia was related with metronidazole. Hypoglycemiaassociated with metronidazole is mainly associated with the use of diabetes medications in previous cases, and few cases ofhypoglycemia in patients without such diabetes have been reported. Therefore, we report hypoglycemia associated with the useof metronidazole in elderly patients without diabetes.
Low-rank tensor completion using nonconvex total variation
Authors:   Cadi Ayyad University, Faculty of Science and Technics, Guiliz, Marrakesh, Morocco, Mohaoui S. , El Qate K. ,   Cadi Ayyad University, Faculty of Science and Technics, Guiliz, Marrakesh, Morocco, Hakim A. ,   Cadi Ayyad University, Faculty of Science and Technics, Guiliz, Marrakesh, Morocco, Raghay S. ,   Cadi Ayyad University, Faculty of Science and Technics, Guiliz, Marrakesh, Morocco
Published: May 2022

In this work, we study the tensor completion problem in which the main point is to predict the missing values in visual data. To greatly benefit from the smoothness structure and edge-preserving property in visual images, we suggest a tensor completion model that seeks gradient sparsity via the l0-norm. The proposal combines the low-rank matrix factorization which guarantees the low-rankness property and the nonconvex total variation (TV). We present several experiments to demonstrate the performance of our model compared with popular tensor completion methods in terms of visual and quantitative measures.
PENGEMBANGAN SISTEM INFORMASI MONITORING TUGAS AKHIR (MONITA) JURUSAN ILMU KOMPUTER FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM UNIVERSITAS LAMPUNG
Authors: Sukma Dimas Aji , Irawati Anie Rose , Heningtyas Yunda , Kurniawan Didik
Published: May 2022

The 2016 Academic Regulations of University of Lampung article 48 stated that; students are obligated to finish their thesis to be avowed as a graduate of a certain bachelor degree. In the Computer Science Department, theses are managed by the thesis coordinator. Thesis coordinator has several tasks, including monitoring the thesis progress of each student. However, in practice, the monitoring process can not be performed easily. Therefore, a thesis monitoring information system is expected to support the thesis coordinator and thesis supervisors in the Computer Science Department on conducting thesis monitoring, as well as accommodating students in terms of administration ease. This research has successfully generated a Thesis Monitoring Information System developed according to the user requirements, by implementing PHP, MySQL, and Nexmo API.
The effect of using pronunciation applications on students' pronunciation abilities
Authors: Shafwati Dian
Published: May 2022

As part of speaking skill, pronunciation has an important factor in learning English as a foreign language, especially in communication. In English communication, if our pronunciation is wrong or inappropriate the result will be miscommunication, even to the point of not conveying the purpose of communication in a conversation because the meaning of a word or sentence is not conveyed properly. So far, the steps for learning and modeling pronunciation in English are done directly or face-to-face. Lecturers and students also need appropriate learning media and support online learning to carry out this Pronunciation course. Regarding applications, the benefits of many applications that are suitable for learning English are; students can watch videos related to the topic, are able to save examples of learning materials, and are able to save the exercises they have done as learning evaluation material for teachers and students later. Applications which are appropriate are the methods which are not only support online learning but can also improve students' pronunciation skills. This study aims to determine whether or not using the pronunciation application have an significant effect on students' pronunciation abilities. This study is used one group pretest-posttest. This design analyzes the results of students' pronunciation abilities at the beginning and at the end of the lesson. The subjects of this study were undergraduate students of the English Education Study Program, FKIP University of Lampung. One class consists of 31 students who take pronunciation courses. Based on the data analysis, the researcher concludes that there is no significant difference of students pronunciation ability before and after taught using pronunciation applications. Meanwhile, we can say that there is slightly significant improvement between pretest of posttest of pronunciation test.