bluuebunny/crossref_metadata_2025 huggingface dataset:
A Simple Method for Fabricating an External Light Extraction Composite Layer with RNS to Improve the Optical Properties of OLEDs
Authors: Choi Geun-Su , Kang Shin-Woo , Bae Eun-Jeong , Jang Eun-Bi , Baek Dong-Hyun , Ju Byeong-Kwon , Park Young-Wook
Published: April 2022

In this study, we fabricated a random nanostructure (RNS) external light extraction composite layer containing high-refractive-index nanoparticles through a simple and inexpensive solution process and a low-temperature mask-free process. We focused on varying the shape and density of the RNSs and adjusted the concentration of the high-refractive-index nanoparticles to control the optical properties. The RNSs fabricated using a low-temperature mask-free process can use the distance between the nanostructures and various forms to control the diffraction and scattering effects in the visible light wavelength range. Consequently, our film exhibited a direct transmittance of ~85% at a wavelength of 550 nm. Furthermore, when the RNSs’ composite film, manufactured using the low-temperature mask-free process, was applied to organic light-emitting diodes (OLEDs), it exhibited an external quantum efficiency improvement of 32.2% compared with the OLEDs without the RNSs. Therefore, the randomly distributed high-refractive-index nanoparticles on the polymer film can reduce the waveguide mode and total reflection at the substrate/air interface. These films can be used as a scattering layer to reduce the loss of the OLED substrate mode.
Analysis of the In Vitro Toxicity of Nanocelluloses in Human Lung Cells as Compared to Multi-Walled Carbon Nanotubes
Authors: Pinto Fátima , Lourenço Ana Filipa , Pedrosa Jorge F. S. , Gonçalves Lídia , Ventura Célia , Vital Nádia , Bettencourt Ana , Fernandes Susete N. , da Rosa Rafaela R. , Godinho Maria Helena , Louro Henriqueta , Ferreira Paulo J. T. , Silva Maria João
Published: April 2022

Cellulose micro/nanomaterials (CMNM), comprising cellulose microfibrils (CMF), nanofibrils (CNF), and nanocrystals (CNC), are being recognized as promising bio-nanomaterials due to their natural and renewable source, attractive properties, and potential for applications with industrial and economical value. Thus, it is crucial to investigate their potential toxicity before starting their production at a larger scale. The present study aimed at evaluating the cell internalization and in vitro cytotoxicity and genotoxicity of CMNM as compared to two multi-walled carbon nanotubes (MWCNT), NM-401 and NM-402, in A549 cells. The exposure to all studied NM, with the exception of CNC, resulted in evident cellular uptake, as analyzed by transmission electron microscopy. However, none of the CMNM induced cytotoxic effects, in contrast to the cytotoxicity observed for the MWCNT. Furthermore, no genotoxicity was observed for CNF, CNC, and NM-402 (cytokinesis-block micronucleus assay), while CMF and NM-401 were able to significantly raise micronucleus frequency. Only NM-402 was able to induce ROS formation, although it did not induce micronuclei. Thus, it is unlikely that the observed CMF and NM-401 genotoxicity is mediated by oxidative DNA damage. More studies targeting other genotoxicity endpoints and cellular and molecular events are underway to allow for a more comprehensive safety assessment of these nanocelluloses.
Driven Engulfment of Janus Particles by Giant Vesicles in and out of Thermal Equilibrium
Authors: Sharma Vaibhav , Marques Carlos M. , Stocco Antonio
Published: April 2022

The interaction between Janus colloids and giant lipid vesicles was experimentally investigated to elucidate the dynamics and mechanisms related to microparticle engulfment by lipid vesicles. Janus (Pt–SiO2 and Pt–MF, where MF is melamine formaldehyde) colloids do not spontaneously adhere to POPC or DOPC bilayers, but by applying external forces via centrifugation we were able to force the contact between the particles and the membranes, which may result in a partial engulfment state of the particle. Surface properties of the Janus colloids play a crucial role in the driven particle engulfment by vesicles. Engulfment of the silica and platinum regions of the Janus particles can be observed, whereas the polymer (MF) region does not show any affinity towards the lipid bilayer. By using fluorescence microscopy, we were able to monitor the particle orientation and measure the rotational dynamics of a single Janus particle engulfed by a vesicle. By adding hydrogen peroxide to the solution, particle self-propulsion was used to perform an active transport of a giant vesicle by a single active particle. Finally, we observe that partially engulfed particles experience a membrane curvature-induced force, which pushes the colloids towards the bottom where the membrane curvature is the lowest.
Perspectives on Iron Oxide-Based Materials with Carbon as Anodes for Li- and K-Ion Batteries
Authors: Valvo Mario , Floraki Christina , Paillard Elie , Edström Kristina , Vernardou Dimitra
Published: April 2022

The necessity for large scale and sustainable energy storage systems is increasing. Lithium-ion batteries have been extensively utilized over the past decades for a range of applications including electronic devices and electric vehicles due to their distinguishing characteristics. Nevertheless, their massive deployment can be questionable due to use of critical materials as well as limited lithium resources and growing costs of extraction. One of the emerging alternative candidates is potassium-ion battery technology due to potassium’s extensive reserves along with its physical and chemical properties similar to lithium. The challenge to develop anode materials with good rate capability, stability and high safety yet remains. Iron oxides are potentially promising anodes for both battery systems due to their high theoretical capacity, low cost and abundant reserves, which aligns with the targets of large-scale application and limited environmental footprint. However, they present relevant limitations such as low electronic conductivity, significant volume changes and inadequate energy efficiency. In this review, we discuss some recent design strategies of iron oxide-based materials for both electrochemical systems and highlight the relationships of their structure performance in nanostructured anodes. Finally, we outline challenges and opportunities for these materials for possible development of KIBs as a complementary technology to LIBs.
Superfluidity of Dipolar Excitons in a Double Layer of α − T3 with a Mass Term
Authors: Berman Oleg L. , Gumbs Godfrey , Martins Gabriel P. , Fekete Paula
Published: April 2022

We predict Bose-Einstein condensation and superfluidity of dipolar excitons, formed by electron-hole pairs in spatially separated gapped hexagonal α−T3 (GHAT3) layers. In the α−T3 model, the AB-honeycomb lattice structure is supplemented with C atoms located at the centers of the hexagons in the lattice. We considered the α−T3 model in the presence of a mass term which opens a gap in the energy-dispersive spectrum. The gap opening mass term, caused by a weak magnetic field, plays the role of Zeeman splitting at low magnetic fields for this pseudospin-1 system. The band structure of GHAT3 monolayers leads to the formation of two distinct types of excitons in the GHAT3 double layer. We consider two types of dipolar excitons in double-layer GHAT3: (a) “A excitons”, which are bound states of electrons in the conduction band (CB) and holes in the intermediate band (IB), and (b) “B excitons”, which are bound states of electrons in the CB and holes in the valence band (VB). The binding energy of A and B dipolar excitons is calculated. For a two-component weakly interacting Bose gas of dipolar excitons in a GHAT3 double layer, we obtain the energy dispersion of collective excitations, the sound velocity, the superfluid density, and the mean-field critical temperature Tc for superfluidity.
Zinc-Ion Storage Mechanism of Polyaniline for Rechargeable Aqueous Zinc-Ion Batteries
Authors: Gong Jiangfeng , Li Hao , Zhang Kaixiao , Zhang Zhupeng , Cao Jie , Shao Zhibin , Tang Chunmei , Fu Shaojie , Wang Qianjin , Wu Xiang
Published: April 2022

Aqueous multivalent ion batteries, especially aqueous zinc-ion batteries (ZIBs), have promising energy storage application due to their unique merits of safety, high ionic conductivity, and high gravimetric energy density. To improve their electrochemical performance, polyaniline (PANI) is often chosen to suppress cathode dissolution. Herein, this work focuses on the zinc ion storage behavior of a PANI cathode. The energy storage mechanism of PANI is associated with four types of protonated/non-protonated amine or imine. The PANI cathode achieves a high capacity of 74 mAh g−1 at 0.3 A g−1 and maintains 48.4% of its initial discharge capacity after 1000 cycles. It also demonstrates an ultrahigh diffusion coefficient of 6.25 × 10−9~7.82 × 10−8 cm−2 s−1 during discharging and 7.69 × 10−10~1.81 × 10−7 cm−2 s−1 during charging processes, which is one or two orders of magnitude higher than other reported studies. This work sheds a light on developing PANI-composited cathodes in rechargeable aqueous ZIBs energy storage devices.
Insight into the Growth Mechanism of Mixed Phase CZTS and the Photocatalytic Performance
Authors: Yang Ying , Ding Yaya , Zhang Jingyu , Liang Nina , Long Lizhen , Liu Jun
Published: April 2022

In this work, CZTS particles with a mixed phase of wurtzite and kesterite were synthesized by the solvothermal method. The time-dependent XRD patterns, Raman spectra, SEM, and EDS analysis were employed to study the growth mechanism of CZTS. The results revealed that the formation of CZTS started from the nucleation of monoclinic Cu7S4 seeds, followed by the successive incorporation of Zn2+ and Sn4+ ions. Additionally, the diffusion of Zn2+ into Cu7S4 crystal lattice is much faster than that of Sn4+. With increasing time, CZTS undergoes a phase transformation from metastable wurtzite to steady kesterite. The morphology of CZTS tends to change from spherical-like to flower-like architecture. The mixed-phase CZTS with a bandgap of 1.5 eV exhibited strong visible light absorption, good capability for photoelectric conversion, and suitable band alignment, which makes it capable to produce H2 production and degrade RhB under simulated solar illumination.
Strong Coupling between a Single Quantum Emitter and a Plasmonic Nanoantenna on a Metallic Film
Authors: Cao Shun , Xing Yuxin , Sun Yuwei , Liu Zhenchao , He Sailing
Published: April 2022

The strong coupling between single quantum emitters and resonant optical micro/nanocavities is beneficial for understanding light and matter interactions. Here, we propose a plasmonic nanoantenna placed on a metal film to achieve an ultra-high electric field enhancement in the nanogap and an ultra-small optical mode volume. The strong coupling between a single quantum dot (QD) and the designed structure is investigated in detail by both numerical simulations and theoretical calculations. When a single QD is inserted into the nanogap of the silver nanoantenna, the scattering spectra show a remarkably large splitting and anticrossing behavior of the vacuum Rabi splitting, which can be achieved in the scattering spectra by optimizing the nanoantenna thickness. Our work shows another way to enhance the light/matter interaction at a single quantum emitter limit, which can be useful for many nanophotonic and quantum applications.
Enhanced Optical Response of Zinc-Doped Tin Disulfide Layered Crystals Grown with the Chemical Vapor Transport Method
Authors: Shih Yu-Tai , Lin Der-Yuh , Li Yu-Cheng , Tseng Bo-Chang , Hwang Sheng-Beng
Published: April 2022

Tin disulfide (SnS2) is a promising semiconductor for use in nanoelectronics and optoelectronics. Doping plays an essential role in SnS2 applications, because it can increase the functionality of SnS2 by tuning its original properties. In this study, the effect of zinc (Zn) doping on the photoelectric characteristics of SnS2 crystals was explored. The chemical vapor transport method was adopted to grow pristine and Zn-doped SnS2 crystals. Scanning electron microscopy images indicated that the grown SnS2 crystals were layered materials. The ratio of the normalized photocurrent of the Zn-doped specimen to that of the pristine specimen increased with an increasing illumination frequency, reaching approximately five at 104 Hz. Time-resolved photocurrent measurements revealed that the Zn-doped specimen had shorter rise and fall times and a higher current amplitude than the pristine specimen. The photoresponsivity of the specimens increased with an increasing bias voltage or decreasing laser power. The Zn-doped SnS2 crystals had 7.18 and 3.44 times higher photoresponsivity, respectively, than the pristine crystals at a bias voltage of 20 V and a laser power of 4 × 10−8 W. The experimental results of this study indicate that Zn doping markedly enhances the optical response of SnS2 layered crystals.
Efficient Selective Removal of Radionuclides by Sorption and Catalytic Reduction Using Nanomaterials
Authors: Xu Min , Cai Yawen , Chen Guohe , Li Bingfeng , Chen Zhongshan , Hu Baowei , Wang Xiangke
Published: April 2022

With the fast development of industry and nuclear energy, large amounts of different radionuclides are inevitably released into the environment. The efficient solidification or elimination of radionuclides is thereby crucial to environmental pollution and human health because of the radioactive hazardous of long-lived radionuclides. The properties of negatively or positively charged radionuclides are quite different, which informs the difficulty of simultaneous elimination of the radionuclides. Herein, we summarized recent works about the selective sorption or catalytic reduction of target radionuclides using different kinds of nanomaterials, such as carbon-based nanomaterials, metal–organic frameworks, and covalent organic frameworks, and their interaction mechanisms are discussed in detail on the basis of batch sorption results, spectroscopy analysis and computational calculations. The sorption-photocatalytic/electrocatalytic reduction of radionuclides from high valent to low valent is an efficient strategy for in situ solidification/immobilization of radionuclides. The special functional groups for the high complexation of target radionuclides and the controlled structures of nanomaterials can selectively bind radionuclides from complicated systems. The challenges and future perspective are finally described, summarized, and discussed.
Plasmonic Micro-Channel Assisted Photonic Crystal Fiber Based Highly Sensitive Sensor for Multi-Analyte Detection
Authors: Kamrunnahar Q. M. , Haider Firoz , Aoni Rifat Ahmmed , Mou Jannatul Robaiat , Shifa Shamsuttiyeba , Begum Feroza , Abdul-Rashid Hairul Azhar , Ahmed Rajib
Published: April 2022

A dual-channel propagation controlled photonic crystal fiber (PCF)-based plasmonic sensor was presented to detect multiple analytes simultaneously. Plasmonic micro-channels were placed on the outer surface of the PCF, which facilitates an easy sensing mechanism. The sensor was numerically investigated by the finite element method (FEM) with the perfectly matched layer (PML) boundary conditions. The proposed sensor performances were analyzed based on optimized sensor parameters, such as confinement loss, resonance coupling, resolution, sensitivity, and figure of merit (FOM). The proposed sensor showed a maximum wavelength sensitivity (WS) of 25,000 nm/refractive index unit (RIU) with a maximum sensor resolution (SR) of 4.0 × 10−6 RIU for channel 2 (Ch-2), and WS of 3000 nm/RIU with SR of 3.33 × 10−5 RIU for channel 1 (Ch-1). To the best of our knowledge, the proposed sensor exhibits the highest WS compared with the previously reported multi-analyte based PCF surface plasmon resonance (SPR) sensors. The proposed sensor could detect the unknown analytes within the refractive index (RI) range of 1.32 to 1.39 in the visible to near infrared region (550 to 1300 nm). In addition, the proposed sensor offers the maximum Figure of Merit (FOM) of 150 and 500 RIU−1 with the limit of detection (LOD) of 1.11 × 10−8 RIU2/nm and 1.6 × 10−10 RIU2/nm for Ch-1 and Ch-2, respectively. Due to its highly sensitive nature, the proposed multi-analyte PCF SPR sensor could be a prominent candidate in the field of biosensing to detect biomolecule interactions and chemical sensing.
A Star Polyamine-Based Nanocarrier Delivery System for Enhanced Avermectin Contact and Stomach Toxicity against Green Peach Aphids
Authors: Yang Yanxiao , Jiang Qinhong , Peng Min , Zhou Ziyi , Du Xiangge , Yin Meizhen , Shen Jie , Yan Shuo
Published: April 2022

The unscientific application of synthesized/botanical pesticides has not only brought the resistance of plant pathogens and pests, but also led to serious environmental pollution. In recent years, various nano-delivery systems have been used for the development of environmental-friendly pesticides with improved efficacy. Herein, the current study constructed an efficient avermectin B1a (AVM) nano-delivery system based on a star polyamine (SPc) and focused on the characterization and bioactivity of SPc-loaded AVM at various mass ratios. The hydroxyl groups of AVM could assemble with carbonyl groups of SPc through hydrogen bond and van der Waals forces, and the self-assembly of AVM and SPc formed nearly spherical particles of AVM/SPc complex with nanoscale size. The contact angle of SPc-loaded AVM decreased with the increasing mass ratio of SPc, revealing the easier distribution and spreading of the AVM/SPc complex. Furthermore, the stomach and contact toxicity of AVM/SPc complex also increased along with the increasing SPc mass ratio, which could be attributed to the enhanced systemic transportation in plants, enlarged contact area to insect pests and stronger permeability across the insect cuticle. The current study provides an efficient nano-delivery system for increasing stomach and contact toxicity of pesticides with wide applications in the agricultural field.
Phase-Selective Synthesis of Mo–Ta–C Ternary Nanosheets by Precisely Tailoring Mo/Ta Atom Ratio on Liquid Copper
Authors: Tu Rong , Yang Hang , Zhang Chitengfei , Li Baowen , Xu Qingfang , Li Qizhong , Yang Meijun , Zhang Song
Published: April 2022

Phase-selective synthesis is an effective way to expand the ultra-thin transition metal carbide family and tune its properties. Herein, a chemical vapor deposition route with specially designed substrate (Ta wire–Cu foil–Mo foil) is carried out to synthesize Mo–Ta–C ternary nanosheets with tunable phase structure. The Ta atoms diffuse on the surface of liquid copper and Mo atoms diffuse through the liquid copper to the surface, which react with the carbon atoms decomposed from the methane and form the Mo–Ta–C ternary nanosheets. By precisely tailoring the Mo/Ta ratio and growth temperature, ultrathin layered orthorhombic (Mo2/3Ta1/3)2C nanosheets and non-layered cubic (Mo0.13Ta0.87) C nanosheets with thickness of 21 and 4 nm are selectively synthesized. The approach could pave the way for the formation of multi-component carbide nanosheets with controllable phases.
Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes
Authors: Kumar Manoj , Pal Namrata , Sharma Poonam , Kumawat Manoj , Sarma Devojit Kumar , Nabi Bilkees , Verma Vinod , Tiwari Rajnarayan R. , Shubham Swasti , Arjmandi Bahram , Nagpal Ravinder
Published: April 2022

Type-2 diabetes mellitus (T2DM) is often linked with hyperglycemia, disturbed lipid profiles, inflammation, and gut dysbiosis. Omega-3 fatty acid supplementation has a vital role in the management of T2DM. As a result, a better understanding of the potential role of omega-3 fatty acids in the development and progression of T2DM by influencing the intestinal microflora will help to improve the therapeutic intervention for T2DM and related complications. Focusing on the molecular mechanisms and signaling pathways induced by omega-3 fatty acids, this paper attempts to comprehensively review and discuss the putative associations between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and its related comorbidities. In addition, we contemplate the importance of gut microbiota in T2DM prevention and treatment and ponder the role of omega-3 fatty acids in T2DM by positively modulating gut microbiota, which may lead to discovery of novel targets and therapeutic strategies thereby paving way for further comprehensive, mechanistic, and clinical studies.
Efficacy of Donated Milk in Early Nutrition of Preterm Infants: A Meta-Analysis
Authors: Li Yu , Chi Cheng , Li Cheng , Song Junyan , Song Zanmin , Wang Wenjun , Sun Jing
Published: April 2022

Background: Preterm birth is associated with an increased risk of many complications, which is a main public health problem worldwide with social and economic consequences. Human milk from breast feeding has been proved to be the optimal nutrition strategy for preterm infants when available. However, the lack of human milk from mothers makes formula widely used in clinical practice. In recent years, donated breast milk has gained popularity as an alternative choice which can provide human milk oligosaccharides and other bioactive substances. Objective: We aimed to conduct a systematic review and meta-analysis to evaluate the nutritional effects of donated breast milk on preterm infants compared with formula. Method: In the present study, we searched Medline, Web of Science, Embase, clinicaltrials.gov, the China national knowledge infrastructure, and the Cochrane central register of controlled trials for candidate randomized controlled trials (RCTs). Results: A total of 1390 patients were enrolled in 11 RCTs and meta-analysis results showed that donated breast milk is also more advantageous in reducing the incidence of necrotizing enterocolitis (NEC, RR = 0.67, 95% CI = 0.48 to 0.93, p = 0.02), reducing the duration of parenteral nutrition (MD = −2.39, 95% CI = −3.66 to −1.13, p = 0.0002) and the time of full enteral feeding (MD = −0.33, 95% CI = −3.23 to 2.57, p = 0.0002). In comparison, formula significantly promotes the growth of premature infants, including their weight gain (MD = −3.45, 95% CI = −3.68 to −3.21, p < 0.00001), head growth (MD = −0.07, 95% CI = −0.08 to −0.06, p < 0.00001) and body length (MD = −0.13, 95% CI = −0.15 to −0.11, p < 0.00001), and reduces the time it takes for premature infants to regain birth weight (MD = 6.60, 95% CI = 6.11 to 7.08, p < 0.00001. Conclusion: Compared with formula, donated breast milk could significantly reduce the incidence of NEC, the duration of parenteral nutrition, and the time of full enteral feeding. Adding fortifiers in donated milk could make it as effective as formula in promoting the physical growth of premature infants.
Nutritional Intake and Biomarker Status in Strict Raw Food Eaters
Authors: Abraham Klaus , Trefflich Iris , Gauch Fabian , Weikert Cornelia
Published: April 2022

Following a strict raw food diet (primarily based on fresh fruit and raw vegetables, waiving any consumption of heated or processed food) has the risk of undersupply of energy and certain macro- and micronutrients. In this cross-sectional study, we compared 16 non-smoking strict raw food eaters (5 women and 11 men, age 44.6 ± 12.3 years, duration of following the diet 11.6 ± 10.8 years) with the non-smoking participants (32 vegans, 27 omnivores) of the “Risk and Benefits of a Vegan Diet” (RBVD) study. We investigated body composition, dietary intake from 3-day weighed food records, and relevant fasting blood and serum parameters. Food choice and dietary behavior were very heterogenic in raw food eaters. They had lower mean values of BMI and percentage of body fat than the respective RBVD participants. The same holds true for energy supply and intakes of protein, carbohydrate, calcium and iodine. Serum levels revealed lower levels of HDL cholesterol, triglycerides, zinc, and vitamin D3. The raw food eaters with (n = 9) and without (n = 7) supplementation of vitamin B12 had median vitamin B12 levels of 399 and 152 ng/L, respectively. Accordingly, eight raw food eaters (50%) had homocysteine levels above 12 µmol/L. The study allows a close look at strict raw food eaters with respect to possible dietary deficiencies, but also provides insights into motivations and daily life.
Association between Use of Nutrition Labels and Risk of Chronic Kidney Disease: The Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2019
Authors: Kim Jonghee , Dorgan Joanne F. , Kim Hyesook , Kwon Oran , Kim Yangha , Kim Yuri , Ko Kwang Suk , Park Yoon Jung , Park Hyesook , Jung Seungyoun
Published: April 2022

Nutrition labeling on food packages is increasingly found to promote healthier food choices associated with lower risk of chronic kidney disease (CKD). To examine associations between nutrition labels use and CKD risk, we conducted a nationally representative cross-sectional study of 32,080 adults from the 2008–2019 Korean National Health and Nutrition Examination Survey. Nutrition labels use was collected via self-reported questionnaires. Ascertainment and severity of CKD was determined by estimated glomerular filtration rate or proteinuria. In multivariable-adjusted (MV) logistic regression models, increasing awareness and use of nutrition labels was significantly associated with lower CKD risk (MV-adjusted OR “nutrition labels aware and use” group vs. “nutrition labels unaware” group [95% CIs]: 0.75 [0.59–0.95], Ptrend:0.03). This inverse association varied with CKD’s risk of progression, with 21% and 42% reduced risk observed for CKD subtypes with “moderate” and “high” risk of progression, respectively (all Ptrend ≤ 0.04). Furthermore, the nutrition labels use and CKD risk association significantly differed by age, with 35% reduced risk observed in the older group aged 49 years or older, but not in the younger group (Pinteraction < 0.001). Our results suggest increasing perception and use of nutrition labels may contribute to CKD prevention and its early asymptomatic progression, especially in older adults.
Competitive Golf: How Longer Courses Are Changing Athletes and Their Approach to the Game
Authors: Zoffer Matthew
Published: April 2022

Nutritional guidance for competitive golfers to improve performance is limited. Recommendations and study conclusions from older research used smaller golf courses compared to today and require a reevaluation of energy expenditure. This review identifies aerobic fitness, in addition to strength, as a key determinant of success. A novel nutritional approach that incorporates carbohydrate supplementation to support aerobic fitness without sacrificing the ability to build strength is presented since longer courses require more stamina. Strategies for training, competition, and recovery are outlined based on different skill levels. American College of Sports Medicine (ACSM) guidelines for carbohydrates, protein, and hydration intake are tailored specifically for competitive golf based on this approach. Putting requires precise movement and can be affected by fatigue. Nutritional studies in golf and similar sports that require focused movements are presented, exhibiting an improvement with adequate hydration and carbohydrate status and caffeine use. Competitive golf poses unique challenges to an athlete and commonly used ergogenic supplements that can improve performance in a variety of circumstances during training, competition, and while traveling are reviewed.
Comment on Szczubełek et al. Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients. Nutrients 2021, 13, 4112
Authors: van Lingen Emilie , van der Marel Sander , Maljaars Jeroen , Keller Josbert , van der Meulen-de Jong Andrea
Published: April 2022

We read with interest the manuscript by Szczubelek et al. [...]
Reply to van Lingen et al. Comment on “Szczubełek et al. Effectiveness of Crohn’s Disease Exclusion Diet for Induction of Remission in Crohn’s Disease Adult Patients. Nutrients 2021, 13, 4112”
Authors: Szczubełek Martyna , Pomorska Karolina , Korólczyk-Kowalczyk Monika , Lewandowski Konrad , Kaniewska Magdalena , Rydzewska Grażyna
Published: April 2022

Thank you for your comment and interest [...]
Addressing Weight Bias in the Cisgender Population: Differences between Sexual Orientations
Authors: Meneguzzo Paolo , Collantoni Enrico , Meregalli Valentina , Favaro Angela , Tenconi Elena
Published: April 2022

(1) Background: Weight bias (WB) is an implicit psychological construct that can influence attitudes, beliefs, body experience, and evaluation of specific psychopathology relationships. Sexual orientation has played a crucial role in developing and maintaining psychiatric conditions linked to body evaluation, but few studies have evaluated possible connected biases. Thus, the paper aims to assess potential relationships between sexual orientation and WB, looking at potential roles in specific psychopathology; (2) Methods: A total of 836 cisgender subjects participated in an online survey, aged between 18 and 42 years old. Two specific aspects of WB were evaluated with validated scales about beliefs about obese people and fat phobia. Demographic variables, as well as depression and eating concerns were evaluated; (3) Results: Gay men and bisexual women showed higher levels of fat phobia, depression, and eating concerns. Regression analysis showed that sexual orientation significantly predicted fat phobia (p < 0.001) and beliefs about obese people (p = 0.014); (4) Conclusions: This study confirms the vulnerability of gay men and bisexual women to cognitive bias about their own bodies, showing a potential vulnerability about body and weight concerns.
Impact of Maternal Health Behaviours and Social Conditions on Infant Diet at Age 1-Year: Results from a Prospective Indigenous Birth Cohort in Ontario, Canada
Authors: Wahi Gita , Wilson Julie , Burning Melanie , George Stephanie , Hill Phyllis , Homer Janet , Jacobs Laurie , Lickers Ashley , Smoke Sharon , Davis Albertha D. , Desai Dipika , Jack Susan M. , Williams Natalie , de Souza Russell J. , Anand Sonia S.
Published: April 2022

Background: Understanding the impact of maternal health behaviours and social conditions on childhood nutrition is important to inform strategies to promote health during childhood. Objective: To describe how maternal health sociodemographic factors (e.g., socioeconomic status, education), health behaviours (e.g., diet), and traditional health care use during pregnancy impact infant diet at age 1-year. Methods: Data were collected from the Indigenous Birth Cohort (ABC) study, a prospective birth cohort formed in partnership with an Indigenous community-based Birthing Centre in southwestern Ontario, Canada. 110 mother-infant dyads are included in the study and were enrolled between 2012 and 2017. Multiple linear regression analyses were performed to understand factors associated with infant diet scores at age 1-year, with a higher score indicating a diet with more healthy foods. Results: The mean age of women enrolled during pregnancy was 27.3 (5.9) years. Eighty percent of mothers had low or moderate social disadvantage, 47.3% completed more than high school education, and 70% were cared for by a midwife during their pregnancy. The pre-pregnancy body mass index (BMI) was <25 in 34.5% of women, 15.5% of mothers smoked during pregnancy, and 14.5% of mothers had gestational diabetes. Being cared for by an Indigenous midwife was associated with a 0.9-point higher infant diet score (p = 0.001) at age 1-year, and lower maternal social disadvantage was associated with a 0.17-point higher infant diet quality score (p = 0.04). Conclusion: This study highlights the positive impact of health care provision by Indigenous midwives and confirms that higher maternal social advantage has a positive impact on child nutrition.
Association of Total, Added, and Natural Phosphorus Intakes with Biomarkers of Health Status and Mortality in Healthy Adults in the United States
Authors: Fulgoni Kristin , Fulgoni Victor L. , Wallace Taylor C.
Published: April 2022

The Western diet is high in dietary phosphorus, partially due to added phosphorus, (i.e., phosphates) predominantly present in processed food products. Elevated serum phosphate levels, otherwise known as hyperphosphatemia, have been associated with changes in health status, of note detrimental effects on cardiovascular and renal health. However, the extent to which highly absorbed added phosphorus contributes to these changes is relatively unknown, due to its poor characterization among food composition databases. Industry-provided data on phosphorus source ingredients and ranges of added phosphorus present in food categories to enable a more accurate estimation of the total, added, and natural phosphorus intakes in the U.S. population. Using regression analyses, we then assessed relationships between estimated total, added, and natural phosphorus intakes on biomarkers of health status and mortality in individuals enrolled in the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 2001–2016 datasets. Total, added, and natural phosphorus intakes were associated with several biomarkers of health status. Added phosphorus intake was consistently inversely associated with HDL cholesterol in both men and women, whereas naturally occurring phosphorus intake was inversely correlated with the risk of elevated blood pressure. However, in most cases, the predicted impact of increases in phosphorus intake would result in small percentage changes in biomarkers. No meaningful associations between phosphorus and mortality were found, but indications of a correlation between mortality with quintiles of naturally occurring phosphorus were present, depending on covariate sets used. The disparate results for natural and added phosphorus intakes within the current study provide increased support for updating current food composition databases to more accurately account for dietary phosphorus intake as total, naturally occurring, and added phosphorus.
The Relationship between Breastfeeding and Initial Vegetable Introduction with Vegetable Consumption in a National Cohort of Children Ages 1–5 Years from Low-Income Households
Authors: Thompson Hannah R. , Borger Christine , Paolicelli Courtney , Whaley Shannon E. , Reat Amanda , Ritchie Lorrene
Published: April 2022

Compared to other food groups, vegetable intakes are lowest relative to recommendations. Breastfeeding and initial introduction to vegetables may help infants establish long-lasting taste preferences. We examined the relationship between breastfeeding and initial vegetable introduction and vegetable intake in early childhood (ages 13–60 months). This repeated cross-sectional study used data from the national WIC Infant and Toddler Feeding Practices Study-2 collected from low-income mother/caregivers about infants from around birth through age 5 (60 months; n = 3773). Survey-weighted adjusted regression models assessed associations between breastfeeding and vegetable introduction measures with vegetable consumption at child ages 13, 24, 36, 48, and 60 months. Longer breastfeeding duration was associated with a slightly, but significantly, greater variety of vegetables consumed/day in early childhood. There was also a small but positive statistically significant association between the number of different types of vegetables consumed on a given day at 9 months and the amount and variety of vegetables consumed/day in early childhood. Age of initial vegetables introduction and whether vegetables were the first/second food introduced were not consistently related to the amount or variety of vegetables consumed later in childhood. Longer breastfeeding and introduction to a greater variety of vegetables at 9 months may be behaviors to target to increase consumption of a greater variety of vegetables by young children.
Nutrigenomics and Nutrigenetics Research in New Zealand, and Its Relevance and Application to Gastrointestinal Health
Authors: Ferguson Lynnette , Barnett Matthew
Published: April 2022

Nutrigenomics New Zealand (NuNZ) was a collaborative research programme built among three organisations—the University of Auckland, AgResearch Limited and Plant & Food Research. The programme ran for ten years, between 2004 and 2014, and was tasked with developing the then emerging field of nutrigenomics, investigating its applications to New Zealand, and potential benefits to the plant food and agricultural sectors. Since the beginning of the programme, nutrigenomics was divided into two fields—nutrigenetics and nutrigenomics. The first of these is now more commonly called personalised nutrition, and has recently been recognised and criticised by elements of the dietetics and management sector in New Zealand, who currently do not appear to fully appreciate the evolving nature of the field, and the differing validity of various companies offering the tests that form the basis of this personalisation. Various science laboratories are utilising “omics” sciences, including transcriptomics, metabolomics, proteomics and the comprehensive analysis of microbial communities such as the gut microbiota, in order to understand the mechanisms by which certain food products and/or diets relevant to New Zealand, confer a health benefit, and the nature of potential health claims that may be made on the basis of this information. In this article, we give a brief overview of the nutrigenomics landscape in New Zealand since the end of the NuNZ programme, with a particular focus on gastrointestinal health.
Effects of Classic Ketogenic Diet in Children with Refractory Epilepsy: A Retrospective Cohort Study in Kingdom of Bahrain
Authors: Perna Simone , Ferraris Cinzia , Guglielmetti Monica , Alalwan Tariq A. , Mahdi Alaa M. , Guido Davide , Tagliabue Anna
Published: April 2022

Background: The classic ketogenic diet (cKD) has been used worldwide as an effective therapy for children with drug-resistant epilepsy. However, there have been no studies performed in Middle Eastern countries in order to assess the efficacy, side effects, predictors of cKD response and factors mostly associated with diet adherence. This study aims to assess the efficacy of cKD ratios of 4:1 and 3:1 and their influence on growth and biochemical parameters, particularly lipid profile and liver function tests (LFTs), and the factors most associated with diet adherence in a cohort of children with drug-resistant epilepsy in Bahrain. Methods: Baseline and follow-up data related to patients’ demographic and biochemical variables, epilepsy episodes, diet history and anthropometric measurements were retrieved for a total of 24 children treated with cKD in Bahrain. Results: After 6 months cKD initiation, 58.3% were positive responders with >50% seizure rate reduction, and 33.3% became seizure-free at 12 months. After 6 months of intervention with cKD, the level of triglycerides and albumin had a significant (p < 0.05) average increase over time of +1.47 mmol/L and 4.3 g/L, respectively. Although the median values of total cholesterol and alanine transaminase increased, respectively, following cKD initiation, the difference over time was not statistically significant. The mean z-scores for weight, height, and body mass index (or weight-for-length) did not change significantly at 12 months follow-up. cKD duration was the highest correlated variable with cKD efficacy (r = 0.76), which was followed by age at cKD initiation (r = 0.47). The cKD was discontinued by 14 patients (58.3%) during the first follow-up period (6 months), which was mainly due to inefficacy (n = 8), poor compliance (n = 3), food refusal (n = 1), achieved required efficacy (n = 1) and death (n = 1). Conclusions: cKD is an effective treatment for patients with drug-resistant epilepsy, and positive response to cKD was the main factor that increased adherence to the diet. Although long-term cKD could increase the risk of dyslipidemia and hepatic problems, it appears safe for children. Consequently, close monitoring and emphasis on healthy fats is of high priority.
Food Sales and Adult Weight Status: Results of a Cross-Sectional Study in England
Authors: Howard Wilsher Stephanie , Harrison Flo , Fearne Andrew , Jones Andy
Published: April 2022

Ecological studies often use supermarket location as a proxy measure of the food environment. In this study, we used data on sales at a leading mainstream supermarket chain to explore how area-level supermarket use is associated with overweight and obesity in English adults. Sales data were aggregated to local authority level and joined to a national dataset describing self-reported height and weight and fruit and vegetable consumption. Regression models showed a modest association between higher levels of unhealthy food sales relative to health food sales and increased odds of being overweight and obese. Although effect sizes were small, they persisted after adjustment for area-level deprivation. Supermarket sales data provide additional understanding in the study of food environments and their impact on increasing weight status. Future health policies should consider using ‘big data’ combined with other research methods to address the increasing consumption of unhealthy and highly processed foods.
Investigation of Behavior and Plasma Levels of Corticosterone in Restrictive- and Ad Libitum-Fed Diet-Induced Obese Mice
Authors: Allweyer Martin , Emde Matthias , Bähr Ina , Spielmann Julia , Bieramperl Philipp , Naujoks Wiebke , Kielstein Heike
Published: April 2022

Diet-induced obesity (DIO) mice models are commonly used to investigate obesity-related health problems. Until now, only sparse data exist on the influence of DIO on behavior and stress hormones in mice. The present study investigates high-fat DIO with two different feeding regimes on behavioral parameters in mice. Various behavioral tests (open field, elevated plus maze, social interaction, hotplate) were performed with female BALB/c and male C57BL/6 mice after a feeding period of twelve weeks (restrictive vs. ad libitum and normal-fat diet vs. high-fat diet) to investigate levels of anxiety and aggression. BALB/c mice were DIO-resistant and therefore the prerequisite for the behavior analyses was not attained. C57BL/6 mice fed a high-fat diet had a significantly higher body weight and fat mass compared to C57BL/6 mice fed a control diet. Interestingly, the DIO C57BL/6 mice showed no changes in their aggression- or anxiety-related behavior but showed a significant change in the anxiety index. This was probably due to a lower activity level, as other ethological parameters did not show an altered anxiety-related behavior. In the ad libitum-fed DIO group, the highest corticosterone level was detected. Changes due to the feeding regime (restrictive vs. ad libitum) were not observed. These results provide a possible hint to a bias in the investigation of DIO-related health problems in laboratory animal experiments, which may be influenced by the lower activity level.
The Administration of Panax Ginseng Berry Extract Attenuates High-Fat-Diet-Induced Sarcopenic Obesity in C57BL/6 Mice
Authors: Shin Ji-Eun , Jeon So-Hyun , Lee Sang-Jun , Choung Se-Young
Published: April 2022

Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of therapeutic agents for sarcopenic obesity is crucial. C57BL/6 mice were fed with a high-fat diet (HFD) for 9 weeks. Then, mice were administered with Panax ginseng berry extract (GBE) for an additional 4 weeks, with continuous HFD intake. GBE significantly decreased the food efficiency ratio, serum lipid and insulin levels, adipose tissue weights, and adipocyte size. It significantly increased the grip strength, muscle masses, and myofiber cross-sectional area. It deactivated the protein kinase C (PKC) theta and zeta, resulting in activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is known to regulate muscle synthesis and degradation. Furthermore, it inhibited the production of inflammatory cytokines in the muscle tissue. GBE attenuated both obesity and sarcopenia. Thus, GBE is a potential agent to prevent or treat sarcopenic obesity.
Nationwide Prevalence and Outcomes of Long-Term Nasogastric Tube Placement in Adults
Authors: Hsu Chung Y. , Lai Jung-Nien , Kung Woon-Man , Hung Chao-Hsien , Yip Hei-Tung , Chang Yu-Chen , Wei Cheng-Yu
Published: April 2022

Tube feeding (TF) is commonly used for patients with severe swallowing disturbance, and patients with chronic dysphagia are often provided with a long-term nasogastric tube (NGT). However, nationwide epidemiological data on long-term NGT placement are limited. The present study identified the prevalence and outcomes of patients with long-term NGT placement in Taiwan. Data were obtained from the Longitudinal Health Insurance Database. Patients with NGT placement for more than 3 months between 2000 and 2012 were enrolled in this cohort study. An NGT cohort of 2754 patients was compared with 11,016 controls matched for age, sex, residential area, and comorbidities. The prevalence rate of long-term NGT reached 0.063% in 2005 and then remained stable at 0.05–0.06%. The major causes of NGT placement were stroke (44%), cancer (16%), head injury (14%), and dementia (12%). Men (63%) were more likely to have long-term NGT placement than women (37%). The adjusted hazard ratios were 28.1 (95% CI = 26.0, 30.3) for acute and chronic respiratory infections; 26.8 (95% CI = 24.1, 29.8) for pneumonia, 8.84 (95% CI = 7.87, 9.93) for diseases of the esophagus, stomach, and duodenum; and 7.5 (95% CI = 14.7, 20.8) for mortality. Patients with NGT placement for more than 6 months had a higher odds ratio (1.58, 95% CI = 1.13, 2.20) of pneumonia than those with NGT placement for less than 6 months. Only 13% and 0.62% of the patients underwent rehabilitation therapy and percutaneous endoscopic gastrostomy, respectively. Long-term NGT use was associated with a higher risk of comorbidities and mortality. Stroke was the main illness contributing to long-term NGT use. Further interventions are necessary to improve the negative effects of long-term TF.
Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study
Authors: Kruszewski Marek , Merchelski Maciej , Kruszewski Artur , Tabęcki Rafał , Aksenov Maksim Olegovich , Pągowski Łukasz
Published: April 2022

The problem addressed in this study is the appropriateness of using different pre-training supplementation strategies and their ability to improve training performance and psychological measures. The aim of the study is the evaluation of the effectiveness of a multi-ingredient pre-workout supplement (MIPS) containing beta-alanine, L-citrulline malate, arginine alpha-ketoglutarate, L-taurine, L-tyrosine and caffeine compared to an exact dosage of anhydrous caffeine in bench press strength endurance, feeling scale (FS), felt arousal scale (FAS) and session rating of perceived exertion (sRPE). A group of fifteen resistance-trained males, weighing 83.92 ± 8.95 kg and having an average of 5.6 ± 3.38 years of training experience, tested their bench press 10 repetition maximum (79.01 ± 12.13). In a cross-over manner, they participated in two sessions where they were blinded to the order of supplementation they were given: either a MIPS including caffeine or caffeine alone. They completed the bench press strength endurance test with pre- and post-training psychological assessments containing FS, FAS and sRPE. Bench press repetition volume was greater after anhydrous caffeine than MIPS supplementation with no difference in psychological measures. These results indicate that MIPS supplementation is less ergogenic and cost effective than caffeine alone.