bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population
Authors: Xu Lu , Hu Liming , Hu Chongyu , Liu Junyu , Li Bingyang , Liao Xin , Zhou Jilin , Liu Songlin , Li Yifeng , Yuan Dun , Jiang Weixi , Yan Junxia
Published: January 2021

Intracranial aneurysm (IA) is a complex disease caused by genetic and environmental factors. Evidence indicates that inflammation plays an important role in IA occurrence. We aimed to explore the associations between inflammatory cytokine gene polymorphisms and IA in a Chinese population. This study enrolled 768 participants of Han ethnicity, including 384 patients with IA and 384 healthy individuals. Sixteen single nucleotide polymorphisms (SNPs) of IL1, IL6, IL12, and TNF-α genes were genotyped using the Sequenom MassARRAY platform. Univariate and multivariate logistic regression analyses were used to analyze the associations. We found IL12B rs3181216 was significantly associated with IA in the recessive and additive models (OR = 0.46, 95% CI = 0.23–0.89, P = 0.022; OR = 0.74, 95% CI = 0.56–0.98, P = 0.034, respectively). TNF-α rs1799964 was associated with IA in dominant and additive models (OR = 0.67, 95% CI = 0.46–0.98, P = 0.041; OR = 0.71, 95% CI = 0.51–0.98, P = 0.034, respectively). IL1A rs17561 was associated with single IA susceptibility (dominant model: OR = 0.52, 95% CI = 0.31–0.85, P = 0.040). The IL12B rs3181216 polymorphism was associated with single IA susceptibility in the recessive model (OR = 0.41, 95% CI = 0.18–0.93, P = 0.033). The IL12B rs2195940 polymorphism was associated with multiple IAs susceptibility (dominant model: OR = 0.28, 95% CI = 0.09–0.89, P = 0.031; additive model: OR = 0.28, 95% CI = 0.09–0.90, P = 0.032). TNF-α rs1799964 was associated with multiple IAs susceptibility in the dominant model (OR = 0.54, 95% CI = 0.30–0.97, P = 0.040). No associations were found between other polymorphisms and IA susceptibility. Therefore, IL1A, IL12B, and TNF-α gene polymorphisms are associated with IA susceptibility in a Chinese population.
Folin-Ciocalteu Reaction Alternatives for Higher Polyphenol Quantitation in Colombian Passion Fruits
Authors: Carmona-Hernandez Juan C. , Taborda-Ocampo Gonzalo , González-Correa Clara H.
Published: January 2021

Passiflora edulis Flavicarpa, Passiflora edulis Sims, and Passiflora ligularis Juss are Colombian fruits (passion fruits) of important exportation value. They act efficiently as antioxidants, antifungal, and antimicrobial compounds due to their high polyphenol content. Polyphenols can be quantified by the Folin-Ciocalteu (F-C) reaction. Food matrices, solvent polarity, and several different reacting conditions are critical for the optimum extraction and quantification of polyphenols. Chromatographic identification and quantitation are satisfactory with access to a vast number of reference standards considering the availability of abundant phenolic compounds in crude extracts. The purpose of this study was to evaluate alternatives and specific F-C reacting conditions aiming at determining the highest total phenolic content (TPC) in three Colombian Passifloras. Among optimum reacting conditions, reduced reaction time and diluted alkali conditions yielded desirable positive results highlighting lower working time and minimum reagent waste production. For higher extraction yield, acetone 70% was the best solvent to capture more phenolics from the seedless pulp of these Colombian passion fruits.
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
Authors: Aboudounya Mohamed M. , Heads Richard J.
Published: January 2021

Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammatory cytokines to combat infection. It is expressed on both immune cells and tissue-resident cells. ACE2, the reported entry receptor for SARS-CoV-2, is only present on ~1-2% of the cells in the lungs or has a low pulmonary expression, and recently, the spike protein has been proposed to have the strongest protein-protein interaction with TLR4. Here, we review and connect evidence for SARS-CoV-1 and SARS-CoV-2 having direct and indirect binding to TLR4, together with other viral precedents, which when combined shed light on the COVID-19 pathophysiological puzzle. We propose a model in which the SARS-CoV-2 spike glycoprotein binds TLR4 and activates TLR4 signalling to increase cell surface expression of ACE2 facilitating entry. SARS-CoV-2 also destroys the type II alveolar cells that secrete pulmonary surfactants, which normally decrease the air/tissue surface tension and block TLR4 in the lungs thus promoting ARDS and inflammation. Furthermore, SARS-CoV-2-induced myocarditis and multiple-organ injury may be due to TLR4 activation, aberrant TLR4 signalling, and hyperinflammation in COVID-19 patients. Therefore, TLR4 contributes significantly to the pathogenesis of SARS-CoV-2, and its overactivation causes a prolonged or excessive innate immune response. TLR4 appears to be a promising therapeutic target in COVID-19, and since TLR4 antagonists have been previously trialled in sepsis and in other antiviral contexts, we propose the clinical trial testing of TLR4 antagonists in the treatment of severe COVID-19. Also, ongoing clinical trials of pulmonary surfactants in COVID-19 hold promise since they also block TLR4.
Effect of Bird Yaw/Pitch Angles on Soft Impact Damage of a Fan Assembly
Authors: Li Junjie , Lou Yunfeng , Yu Gaoyuan , Li Tong , Jin Xianlong
Published: January 2021

This paper presents a numerical investigation of bird attitude angles affecting the soft‐impact damage of a full fan assembly. Firstly, considering the geometry of a mallard, a real bird model is established by the Smoothed Particle Hydrodynamics (SPH) method and calibrated with available test data. Then, complying with airworthiness requirements, simulations of a full‐bladed fan assembly subjected to a real bird were conducted to determine the critical ingestion parameters (CIP). Furthermore, a real bird with different attitude angles aimed at a full fan assembly was simulated. Results show that attitude angles of the bird produce a significant impact on the effect of the bird strike on rotating blades and would increase the possibility of blade failures, especially for the yaw angle of ‐45° and the pitch angle of −60°. It is invaluable for commercial airlines and engine manufactures to provide safe flight and landing by adopting the real bird model with critical yaw and pitch angles in the design for resistance to bird ingestion.
A Decision-Making Method for Ship Collision Avoidance Based on Improved Cultural Particle Swarm
Authors: Zheng Yisong , Zhang Xiuguo , Shang Zijing , Guo Siyu , Du Yiquan
Published: January 2021

In the process of ship collision avoidance decision making, steering collision avoidance is the most frequently adopted collision avoidance method. In order to obtain an effective and reasonable steering angle, this paper proposes a decision-making method for ship collision avoidance based on improved cultural particle swarm. Firstly, the ship steering angle direction is to be determined. In this stage, the Kalman filter is used to predict the ship’s trajectory. According to the prediction parameters, the collision risk index of the ship is calculated and the situation with the most dangerous ship is judged. Then, the steering angle direction of the ship is determined by considering the Convention on the International Regulations for Preventing Collisions at Sea (COLREGs). Secondly, the ship steering angle is to be calculated. In this stage, the cultural particle swarm optimization algorithm is improved by introducing the index of population premature convergence degree to adaptively adjust the inertia weight of the cultural particle swarm so as to avoid the algorithm falling into premature convergence state. The improved cultural particle swarm optimization algorithm is used to find the optimal steering angle within the range of the steering angle direction. Compared with other evolutionary algorithms, the improved cultural particle swarm optimization algorithm has better global convergence. The convergence speed and stability are also significantly improved. Thirdly, the ship steering angle direction decision method in the first stage and the ship steering angle decision method in the second stage are integrated into the electronic chart platform to verify the effectiveness of the decision-making method of ship collision avoidance presented in this paper. Results show that the proposed approach can automatically realize collision avoidance from all other ships and it has an important practical application value.
Proton Pump Inhibitors and Fractures in Adults: A Critical Appraisal and Review of the Literature
Authors: Briganti Silvia Irina , Naciu Anda Mihaela , Tabacco Gaia , Cesareo Roberto , Napoli Nicola , Trimboli Pierpaolo , Castellana Marco , Manfrini Silvia , Palermo Andrea
Published: January 2021

Despite the large number of patients worldwide being on proton pump inhibitors (PPIs) for acid-related gastrointestinal disorders, uncertainty remains over their long-term safety. Particularly, the potential side effects of these drugs on bone health have been evaluated in the last years. The purpose of our narrative review is to gather and discuss results of clinical studies focusing on the interactions between PPIs and fracture risk. Data generated mainly from nested case-control studies and meta-analysis suggest that long-term/high-dose PPIs users are characterized by an increased risk of fragility fractures, mainly hip fractures. However, in these studies, the PPIs-induced bone impairment is often not adjusted for different confounding variables that could potentially affect bone health, and exposure to PPIs was reported using medical prescriptions without adherence evaluation. The mechanisms of the PPI-related bone damage are still unclear, but impaired micronutrients absorption, hypergastrinemia, and increased secretion of histamine may play a role. Clinicians should pay attention when prescribing PPIs to subjects with a preexistent high risk of fractures and consider antiosteoporotic drugs to manage this additive effect on the bone. However, further studies are needed to clarify PPIs action on the bone.
Prognostic Impacts of Comorbid Significant Coronary Stenosis and Coronary Artery Spasm in Patients With Stable Coronary Artery Disease
Authors: Hao Kiyotaka , Takahashi Jun , Kikuchi Yoku , Suda Akira , Sato Koichi , Sugisawa Jun , Tsuchiya Satoshi , Shindo Tomohiko , Nishimiya Kensuke , Ikeda Shohei , Tsuburaya Ryuji , Shiroto Takashi , Matsumoto Yasuharu , Miyata Satoshi , Sakata Yasuhiko , Yasuda Satoshi , Shimokawa Hiroaki
Published: January 2021

BACKGROUND

Stable coronary artery disease is caused by a variable combination of organic coronary stenosis and functional coronary abnormalities, such as coronary artery spasm. Thus, we examined the clinical importance of comorbid significant coronary stenosis and coronary spasm.

METHODS AND RESULTS

We enrolled 236 consecutive patients with suspected angina who underwent acetylcholine provocation testing for coronary spasm and fractional flow reserve (FFR) measurement. Among them, 175 patients were diagnosed as having vasospastic angina (VSA), whereas the remaining 61 had no VSA (non‐VSA group). The patients with VSA were further divided into the following 3 groups based on angiography and FFR: no organic stenosis (≤50% luminal stenosis; VSA‐alone group, n=110), insignificant stenosis of FFR>0.80 (high‐FFR group, n=36), and significant stenosis of FFR≤0.80 (low‐FFR group, n=29). The incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, urgent percutaneous coronary intervention, and hospitalization attributed to unstable angina was evaluated. All patients with VSA received calcium channel blockers, and 28 patients (95%) in the low‐FFR group underwent a planned percutaneous coronary intervention. During a median follow‐up period of 656 days, although the incidence of major adverse cardiovascular events was low and comparable among non‐VSA, VSA‐alone, and high‐FFR groups, the low‐FFR group had an extremely poor prognosis (non‐VSA group, 1.6%; VSA‐alone group, 3.6%; high‐FFR group, 5.6%; low‐FFR group, 27.6%) (
P
<0.001). Importantly, all 8 patients with major adverse cardiovascular events in the low‐FFR group were appropriately treated with percutaneous coronary intervention and calcium channel blockers.

CONCLUSIONS

These results indicate that patients with VSA with significant coronary stenosis represent a high‐risk population despite current guideline‐recommended therapies, suggesting the importance of routine coronary functional testing in this population.
Web-Conference Lecturing: In Dialogue with Student Experiences During a Pandemic
Authors: Westbrook Fiona , Tibb Anna , Blackall Leigh , Zabde Hepsibah
Published: January 2021

covid-19 is an omnipresent feature of 2020, both globally and within Australia. For university students, a consequence of this has been the shift from on-campus to online delivery. Exploring these visual realities for lecturers and students, this article engages in Bakhtinian dialogism; a dialogic interaction that is born between peoples searching for meaning (Bakhtin, 1986). To do so, the authors engaged with and responded to students’ survey data whom they lecture and coordinate. Although the survey had limited responses, it enabled the authors to dialogue about received knowledge (istina) from students and contemplate this in relation to the authors’ own perspectives and experiences (pravda). Through this engagement, they suggest the importance of visually imbued emotive connectivity and dialogic relational care within web-conferencing, as well as didactic lecturing as valid forms of visual engagement.
A Virtual Choir Ecology and the Zoom-machinic
Authors: Grushka Kathryn , Lawry Miranda , Sutherland Kim , Fergusson Charissa
Published: January 2021

covid-19 has changed the way we sing in choirs and has seen the extraordinary uptake of Zoom as a video chat platform across society. This is a reflective tale of four choirs members and their insights into how they improvised with traditional choir singing in a Zoom space. It consideres how zoom pedagogies allowed them to bridge social isolation during the pandemic. It includes the voices of the conductor; music teacher/technician; the voice of a media savvy artist choir member and finally the voice of a singing visual educator. The article embeds Deleuzoguattarian thinking. It draws on the concepts of the machinic assemblage and becoming as choir participants who embraced Zoom to facilitate song. Singing in a zoom virtual choir brings forth a burgeoning new relational way of being. To find ways to sing and imagine life and self without physical, temporal and spatial borders.
Tribute to Judi Trent
Authors: Friedenberg Robert V.
Published: January 2021

I first met Judi in the academic year 1971-1972. I had been hired a year earlier by Miami University, Oxford, Ohio, and Judi’s husband, Jimmie Trent, was hired that year to chair my department. Judi found a position at the University of Dayton and commuted there from Oxford. Our friendship and our regular revision of our book kept Judi and me in constant contact as did many other projects and many mutual friends. Over the years we got to know each other very well. What began largely as a professional friendship grew into a personal one as well. While I have always considered Judi to be an excellent researcher and writer, I am most pleased to call Judi a good friend.
Helping Children with Special Needs: Who Receives Tympanostomy Tubes?
Authors: Wassef David W. , Dhaduk Nehal , Roy Savannah C. , Barinsky Gregory L. , Kalyoussef Evelyne
Published: January 2021

Objectives:

Tympanostomy tubes can prevent sequelae of otitis media that adversely affect long term hearing and language development in children. These negative outcomes compound the existing difficulties faced by children who are already diagnosed with developmental disorders. This study aims to characterize this subset of children with developmental disorders undergoing myringotomy and tympanostomy tube insertion.

Methods:

A retrospective review using the Kids’ Inpatient Database (KID) was conducted, with codes from International Classification of Diseases, Ninth Revision used to query data from the years 2003 to 2012 to determine a study group of children with a diagnosis of a developmental disorder undergoing myringotomy and tympanostomy insertion. This group was compared statistically to patients undergoing these procedures who did not have a diagnosed developmental disorder.

Results:

In total, 21 945 cases of patients with myringotomy with or without tympanostomy tube insertion were identified, of which 1200 (5.5%) had a diagnosis of a developmental disorder. Children with developmental disorders had a higher mean age (3.3 years vs 2.9 years, P = .002) and higher mean hospital charges ($43 704.77 vs $32 764.22, P = .003). This cohort also had higher proportions of black (17.6% vs 12.3%, P < .001) and Hispanic (23.9% vs 20.6%, P = .014) patients, and had lower rates of private insurance coverage (39.6% vs 49%, P < .001).

Conclusion:

The population of children with developmental disorders undergoing myringotomy or tympanostomy tube placement has a different demographic composition than the general population and faces distinct financial and insurance coverage burdens. Further study should be done to assess if these differences impact long term outcomes.
The Effect of Lateral Pharyngeal Collapse Patterns on Therapy Response in Upper Airway Stimulation Surgery
Authors: Flynn John , Boyd Christopher , Yalamanchali Sreeya , Rouse David , Goodwin Sara , Penn Joseph , Larsen Christopher
Published: January 2021

Objectives:

Obstructive sleep apnea (OSA) is characterized by repeated upper airway collapse while sleeping which leads to intermittent hypoxemia. Upper airway stimulation (UAS) is a commonly practiced modality for treating OSA in patients who cannot tolerate, or do not benefit from, positive airway pressure (PAP). The purpose of this study is to identify the effect of lateral pharyngeal collapse patterns on therapy response in UAS.

Methods:

A retrospective cohort study from a single, tertiary-care academic center was performed. Patients who underwent UAS between October 2016 and July 2019 were identified and analyzed. Drug-induced Sleep Endoscopy (DISE) outcomes between Apnea-Hypopnea Index (AHI) responders and AHI non-responders were compared. Those with complete concentric collapse at the velopharynx were not candidates for UAS.

Results:

About 95 patients that underwent UAS were included in this study. Pre- to Post-UAS demonstrated significant improvements in Epworth Sleepiness Scale (12.0 vs 4.0, P = .001), AHI (29.8 vs 5.4, P < .001) and minimum oxygen saturation (79% vs 83%, P < .001). No DISE findings significantly predicted AHI response after UAS. Specifically, multiple types of lateral pharyngeal collapse patterns did not adversely effect change in AHI or AHI response rate.

Conclusion:

Demonstration of lateral pharyngeal collapse on DISE, in the absence of complete concentric velopharyngeal obstruction, does not appear to adversely affect AHI outcomes in UAS patients.

Level of Evidence

VI
The Roles of Family, Community, and Services in the Prevention of Illicit Drug Use: Findings From a Sample of Released Prisoners
Authors: Liu Lin , Visher Christy A.
Published: January 2021

Studies show that the deterioration of family bonds and financial difficulty are barriers to a successful reintegration after incarceration. However, how family, community, and correction agencies simultaneously affect individuals’ illicit drug use during reentry is rarely examined. This study draws insights from the systemic model of social disorganization and examines the joint effects of private, parochial, and public levels of social control on post-release drug use. We used a longitudinal data set that captured family relationships, community cohesiveness, and reentry program participation of released prisoners. Findings provide empirical support for the application of the systemic model of social disorganization on illicit drug during reentry. The various levels of social control defined by this theory were found to exhibit significant and inhibitory effects on individuals’ drug use after release. This study advances our understanding of individuals’ reentry outcomes by highlighting the joint influence of family, community, and correction agencies. Policy implications for addressing post-release drug use are presented.
Airbnb and its potential impact on the London housing market
Authors: Shabrina Zahratu , Arcaute Elsa , Batty Michael
Published: January 2021

This article identifies proxies which account for the impacts that the Airbnb platform is having on housing in Greater London. We identify these by analysing the relationships between possible Airbnb misuse and the attributes of housing in the same locations. We assume misuse when listings of entire properties within the Airbnb platform do not conform with local regulations and where hosts who offer such housing have multiple listings. In particular, we examine (1) the dwelling type based on building typology; (2) the type of housing tenure, whether it is owned or rented; and (3) the spatial distribution of changes in rent payable. Three important findings emerge from our analysis. First, based on 2018 data, we estimate that more than 2% of all properties in London, and up to 7% in some local areas are being misused through Airbnb as short-term holiday rentals. Second, the location of these particular Airbnb rentals is negatively correlated with the diversity of dwelling types and positively correlated with dwelling type such as an apartment (or flat) in areas of high private rental stock. Last, we show that a 100% increase in the density of possible Airbnb misuse can be associated with up to an 8% increase in unit rental price per-bedroom per-week, an equivalent to up to an average of £90 price increase per year. Finally, we discuss how this type of analysis can help build instruments to inform policies associated with the platform economy in relation to increasing polarisation in the London housing market.
“A Good Deal of Intensity”: On the Development of Degree and Quantity Modifier Good
Authors: Ghesquière Lobke
Published: January 2021

This paper explores how the originally descriptive adjective good (e.g., “a good man”) developed degree modifier (e.g., “a good scolding”) and quantity modifier (e.g., “a good many people”) uses. The work is innovative in exploring the intensification potential of unbounded rather than bounded adjectives and in distinguishing between degree and quantity modification, the latter only recently gaining attention in the cognitive-functional literature. The developmental path of good will be linked to its construal in terms of scalarity, the process of subjectification, and the categorial shift from modification to submodification.
The association of psychiatric and neurological comorbidities with outcomes in traumatic injury patients
Authors: Brady Jennifer , Hayward R David , Edhayan Elango
Published: January 2021

Introduction

Mental illness is a well-known risk factor for injury and injury recidivism. The impact of pre-existing psychiatric illness on trauma outcomes, however, has received less attention. Our study examines the relationship of pre-existing psychiatric illness on trauma outcomes including length of stay, cost, and mortality.

Methods

Patient data were obtained from the Healthcare Cost and Utilization Project’s State Inpatient Database. All patients admitted for trauma in the Detroit metropolitan area from 1/1/2006 to 12/31/2014 were included. The relationship between individual psychiatric comorbidities (depression, psychosis, and other neurological disorders) and outcomes were evaluated with logistic regression (mortality) and generalized linear modeling (length of stay and cost).

Results

Over 260,000 records were reviewed. Approximately one-third (29.9%) of patients had one or more psychiatric diagnoses. Patients with depression had longer hospital stays (RR = 1.12, p < 0.001) and higher costs (RR = 1.07, p < 0.001), but also lower mortality (OR = 0.69, p < 0.001). Patients with psychosis had longer stays (RR = 1.18, p < 0.001), higher costs (RR = 1.02, p = 0.002), and lower mortality (OR = 0.61, p < 0.001). Patients with other neurological comorbidities had higher mortality (OR = 1.23, p < 0.001), longer stays (RR = 1.29, p < 0.001), and higher costs (RR = 1.10, p < 0.001).

Conclusion

Patients with a psychiatric disorder required longer care and incurred greater costs, whereas mortality was higher for only those with a neurological disorder. Identifying patients’ psychiatric comorbidities at the time of admission for trauma may help optimize treatment. Addressing these conditions may help reduce the cost of trauma care.
The Effects of Offering Proactive Student-Success Coaching on Community College Students’ Academic Performance and Persistence
Authors: Hall Mark M. , Worsham Rachel E. , Reavis Grey
Published: January 2021

Objective:

This study examined the effects of offering proactive student-success coaching, informed by predictive analytics, on student academic performance and persistence. Specifically, this study investigated semester grade point average (GPA) and semester-to-semester persistence of community college students as outcomes.

Methods:

This study involved two stages of analysis. First, we used inverse probability of treatment weighting to create appropriately balanced samples of the students offered proactive assistance and students not offered proactive assistance to approximate a randomized control trial with observational data. Then, we applied regression analyses with weights and covariates to the balanced samples to estimate outcomes.

Results:

Using regression analyses with weights and covariates, we estimated few statistically significant results in sample subgroup models and no statistically significant results for whole-group samples. Generally, our analyses found that the offer of the intervention had no effect on students’ persistence and semester GPAs.

Conclusions/Contributions:

This study contributes empirical results to the emerging literature regarding student-success coaching, predictive analytics, and student-monitoring systems. The results demonstrate the necessity of performing rigorous analyses on these predictive-analytic systems and reveals ethical concerns that should be considered in designing interventions.
Parent–Child Anxiety Symptoms in Emerging Adults: Moderation by Gender and Religiosity
Authors: Stearns Melanie , McKinney Cliff
Published: January 2021

Although research has indicated that parent and child anxiety are connected, religiosity may serve as a protective factor and help weaken this connection. The current study asked 1,002 emerging adults (67.7% female) to report on their mothers’ and fathers’ anxiety symptoms and their own anxiety symptoms and religiosity. Structural equation modeling indicated that personal religiosity served as a moderator between the perceived anxiety symptoms of mothers and fathers and emerging adult anxiety symptoms for daughters but not sons. Participant gender also suggested a 3-way interaction among variables as the interactions occurred for daughters but not sons. Additionally, parent gender suggested a 3-way interaction, given that the results indicated that for emerging adult daughters, the interaction was stronger for mothers than fathers. Thus, emerging adult religiosity as well as parent and child gender may be contributing factors to better understanding of how offspring anxiety relates to that of their parents.
Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review
Authors: Torossian Maral , Fiske Sarah Marie , Jacelon Cynthia S.
Published: January 2021

Sleep disturbance in mild cognitive impairment (MCI) is associated with progression to Alzheimer’s disease (AD), more severe AD symptoms, and worse health outcomes. The aim of this review was to examine the relationship between sleep and MCI, and the effectiveness of sleep improvement interventions for older adults with MCI or AD. An integrative review was conducted using four databases, and findings were analyzed using an iterative process. Findings from 24 studies showed that alterations in sleep increased the risk of MCI and that the sleep quality of individuals with MCI or AD was poorer than healthy controls. Changes in brain anatomy were also observed in healthy older adults with sleep disturbances. Examined interventions were shown to be effective in improving sleep. Screening for sleep disturbances in individuals with MCI/AD is crucial to mitigate neurodegenerative or neurobehavioral risks in this population.
Differences in the Selection of Health State Utility Values by Sponsorship in Published Cost-Effectiveness Analyses
Authors: Hendrix Nathaniel , Kim David D. , Patel Krishna S. , Devine Beth
Published: January 2021

Background

Health state utility values (HSUVs) are among the most influential attributes of cost-effectiveness analyses (CEAs). Our objective was to evaluate whether industry-funded studies select systematically different HSUVs as compared with studies without industry funding.

Methods

Among 10 diseases with high disease burden in the United States, we further identified 31 progressive health states. We then searched the Tufts Medical Center’s CEA Registry to identify studies that included HSUVs and were submitted to the registry between 2002 and 2019. Two reviewers mapped the free-text descriptions of health states onto the 31 predefined health states. We analyzed the effect of industry funding on the point estimates of these HSUVs with a beta regression. We also analyzed the difference between related health states within studies by funding source with a linear regression.

Results

After identifying 26,222 HSUVs from 4198 CEAs, we matched 2573 HSUVs to the 31 predefined health states. We observed large variations within each health state: 12 of 31 health states included a range of HSUVs greater than 0.5. The point estimate model showed 1 statistically significant difference of 31 comparisons between studies with any industry funding and those without. The utility difference model found 3 significant differences out of 39 comparisons between CEAs with any industry funding and those without.

Limitations

Inclusion of unpublished CEAs may have affected our conclusions about the effect of industry funding on selection of HSUVs. We also relied on free-text descriptions of health states available in the CEA Registry and did not include adjustment for multiple comparisons.

Conclusion

Limited evidence exists that industry-funded studies select different HSUVs compared to non-industry-funded studies for the health states we considered.
Efficacy of Advance Care Planning Videos for Patients: A Randomized Controlled Trial in Cancer, Heart, and Kidney Failure Outpatient Settings
Authors: Douglas Maureen L. , Simon Jessica , Davison Sara N. , Biondo Patricia , Ghosh Sunita , Kassam Aliya , Fassbender Konrad
Published: January 2021

Background

Patient videos about advance care planning (ACP; hereafter “Videos”), were developed to support uptake of provincial policy and address the complexity of patients’ decision-making process. We evaluate self-administered ACP Videos, compare the studies’ choice of outcomes, show correlations between the patients’ ACP actions, and discuss implications for health care policy.

Objective

To test the efficacy of the Videos on patients’ ACP/goals of care designation conversations with a health care provider.

Design, Setting, and Participants

Using a 2-arm, 1:1 randomized controlled trial, we recruited outpatients with a diagnosis of kidney failure, heart failure, metastatic lung, gastrointestinal, or gynecological cancer from 22 sites. Analysis followed the intention-to-treat principle.

Interventions

Videos describing the ACP process and illustrating the resuscitative, medical, and comfort levels of care.

Main Outcomes and Measures

The primary outcome was the proportion of participants who reported having an ACP/goals of care designation (GCD) conversation with a health care provider by 3 mo. Outcomes were measured using the Behaviours in Advance Care Planning and Actions Survey, an online survey capturing ACP attitudes, processes, and actions.

Results

We analyzed 241 and 217 participants at baseline and 3 mo, respectively. The proportion of participants who had an ACP/GCD conversation with a health care provider by 3 mo was significantly different between study arms (46% intervention; 32% control; adjusted odds ratio, 1.83; P = 0.032). Adjusted for the quality of conversations, there was no significant difference.

Conclusions

Videos as stand-alone tools do not engage individuals in high-quality ACP. Pragmatic trials are necessary to evaluate their impact on downstream outcomes when integrated into intentional, comprehensive conversations with a health care provider. Considering the strong correlation between 2 activities (physicians discussing options, patients telling health care providers preferences), policy should focus on empowering patients to initiate these conversations.
Analytical Elastic Modeling of Rail and Fastener Longitudinal Response
Authors: Trizotto Matheus , Dersch Marcus S. , Edwards J. Riley , Lima Arthur
Published: January 2021

The rail fastening system plays a critical role in maintaining proper railroad track geometry by transferring vertical, lateral, and longitudinal forces from the rails to crossties. Broken spikes in elastic fastening systems have been linked to inadequate transfer of longitudinal loads, posing a safety risk for timber crosstie ballasted track. Longitudinal track demand caused by passing trains has been investigated in previous research, but the magnitude and distribution of longitudinal fastener loads is not well understood or documented. To address these track component failures and improve fastener design, this paper presents a validated analytical model that estimates longitudinal rail seat loads, advancing current formulations to focus specifically on the rail seat. The validated method was used to quantify the distribution and magnitude of longitudinal loads in both the rail and fastening system caused by passing trains. Further, this paper quantifies the effect of track stiffness, number of powered locomotives, and wheel spacing on these distributions and magnitudes. This information provides valuable insight into the specific type of spike failures that have led to at least ten derailments and the requirement of manual walking inspections on multiple North American heavy axle load railroads as detailed in this paper. Further, this method can be used to quantify the longitudinal fastener loads for different track conditions to advance the mechanistic-empirical track design philosophy for elastic fastening systems.
Statewide Application of Wrong-Way Driving Crash Risk Modeling and Countermeasures Optimization Algorithm to Identify Optimal Locations for Countermeasure Deployment on Florida Limited Access Facilities
Authors: Sandt Adrian , Al-Deek Haitham , Blue Patrick , McCombs John
Published: January 2021

Wrong-way driving (WWD) crashes can have significant impacts on freeway safety and operations. Deploying intelligent transportation systems (ITS) WWD countermeasures at freeway exit ramps can effectively reduce WWD crash risk (WWCR), but these countermeasures are expensive. In this paper, a WWCR segment model and WWD countermeasures optimization algorithm are developed for all Florida limited access facilities (56 roadways with 1,375 exits) to identify the optimal locations for ITS countermeasure deployment. These were previously developed for specific toll-road networks within Florida, but never for a statewide network. Multiple WWCR models were investigated, with the final Poisson model using four-exit segments and 5 years of WWD event data. This model showed that more WWD events and higher crossing road traffic volumes increased WWCR, while certain interchange designs increased or decreased WWCR. Sixty-three segments containing 169 exit ramps without ITS WWD countermeasures were identified as WWD hotspots; these ramps were compared with the 169 ramps with the highest WWCR selected by the optimization algorithm. The algorithm selected 96 ramps not in the hotspots (improved resource utilization of 56.8%) and provided a 38.6% increase in WWCR reduction. Comparing WWD detection and turnaround data from 31 sites with rectangular flashing beacon ITS countermeasures to the optimization indicated a significant positive association between WWCR and turnaround percentage (higher WWCR at sites with lower turnaround percentage), verifying the accuracy of the optimization. By showing the transferability, scalability, accuracy, and benefits of this approach, this paper can help agencies reduce WWD and improve freeway safety and operations.
Exploratory Analysis of Unmanned Aircraft Sightings using Text Mining
Authors: Das Subasish
Published: January 2021

Because of recent technological advancements, a growing number of unmanned aircraft systems (UASs) are anticipated to occupy the U.S. National Airspace System (NAS) and operate side-by-side with human pilot controlled civil aircraft. UAS technology has transitioned to broader applications, including commercial, scientific, and expanded military use. There have been significant challenges concerning the safe and suitable integration of UASs with existing systems. The interaction between humans and increasingly automated systems is of concern to researchers. Additionally, the number of UAS sightings has increased significantly during the last few years. In this study, the research team compiled 7,400 reports of UAS sightings (2015–2018). The Latent Dirichlet Allocation (LDA) method was then applied to develop topics relevant to UAS sighting incidents. This study also developed an online interactive tool to show keywords associated with different topics. These interactive topic models can help policymakers establish new policies and regulations to address specific safety concerns.
Incentives Can’t Buy Me Knowledge: The Missing Effects of Appreciation and Aligned Performance Appraisals on Knowledge Sharing of Public Employees
Authors: Fischer Caroline
Published: January 2021

This study examines whether incentives affect public employees’ intention to share knowledge. Tested incentives satisfy needs for either achievement or appreciation. Both treatments were tested on implicit as well as explicit knowledge sharing. A 2 × 3 factorial survey experiment was designed to observe within-person and between-person effects. Data were collected from public employees in the core administration and healthcare sector ( n = 623) in 2018. The analysis indicates that both treatments positively affect knowledge-sharing intention if it is explicit knowledge that ought to be shared. However, no effects of either treatment can be found in either type of knowledge sharing. No negative effect of the tested incentives on knowledge sharing was observed. Hence, incentives might not harm knowledge sharing but also do not pay off in organizational practice. In contrast to these motivation-enhancing human resource practices, ability and opportunity-enhancing practices should be tested to foster knowledge sharing.
The Role of Sensitivity to Reward and Punishment in Aggression
Authors: Megías-Robles Alberto , Gómez-Leal Raquel , Gutiérrez-Cobo María José , Cabello Rosario , Fernández-Berrocal Pablo
Published: January 2021

The study of the risk and protective factors in aggression is of fundamental importance for our society. The aim of this research was to clarify the role of sensitivity to reward/punishment in aggression and provide a better understanding of the mechanisms underlying this relationship, particularly given that previous studies in the literature have yielded mixed results. To this end, two studies were conducted. In Study 1 (484 participants; Mage = 39.09; 48.6s women), we explored the relationship between sensitivity to reward and punishment and four components of aggression: physical, verbal, anger, and hostility. In Study 2 (229 participants; Mage = 21.52; 56.77% women), we investigated the moderating role of emotion regulation ability in this relationship. The findings of Studies 1 and 2 supported the existence of a positive relationship between sensitivity to reward and aggression, that is, a high reactivity to reward acted as a risk factor. With respect to sensitivity to punishment, mediation analysis revealed that this variable may act both as a protective factor as well as a risk factor for behavioral aggression. A higher reactivity to punishment had a direct negative effect on physical and verbal aggression, inhibiting aggressive behavior. However, a higher reactivity to punishment also implied a positive indirect effect on physical and verbal aggression through an increase in anger and hostility. Interestingly, Study 2 revealed that these indirect effects were moderated by emotion regulation ability. Our results could help to inform the design of aggression prevention and intervention programs for reducing the impact of this behavior on our society.
Adolescent Victims of Physical Dating Violence: Why Do They Stay in Abusive Relationships?
Authors: Muñoz-Rivas Marina , Ronzón-Tirado Rosa Carolina , Redondo Natalia , Cassinello María Dolores Zamarrón
Published: January 2021

According to recent international studies, most of the adolescent victims of physical dating violence remain satisfied and committed toward their abusive relationship, giving way to long-term relationships in which the abuse tends to persist and increase in frequency and severity. The objective of this study is to contribute to the understanding of the stay/leave decision of the adolescent victims of physical dating violence. A structural equation model was estimated to explain the direct and indirect contribution of the level of satisfaction, commitment, justification of the aggression, relationship duration, psychological coercion toward commitment, and the consequences of the abuse on the victims’ decision to continue in the abusive relationship. The sample was 456 Latinx adolescents aged between 12 and 18 years. The results corroborate that the decision to leave a physically abusive dating relationship is a complex phenomenon related to subjective variables such as (a) the level of satisfaction, (b) cognitive evaluation of the aggression (especially in those couples who have been together for a long time), and (c) the exposure to psychological pressures toward commitment. Future preventive strategies must incorporate actions to help the youngest to evaluate in a more objective and adequate way, the real quality of their first relationships, and aim to modify the justification of the aggression, the recognition of the potential harm, and to foster an adequate balance between the benefits and harm of staying in the abusive relationship.
Normal Neonatal Electroencephalogram at a Glance
Authors: Cappellari Alberto M.
Published: January 2021

Interpreting neonatal electroencephalogram (EEG) presents a challenge owing to rapid evolution of EEG patterns occurring during brain maturation in the neonatal period and rich variety of normal patterns of EEG activity, which is difficult to categorize completely. Furthermore, the description of some aspects during maturation varies in different studies. Neonatal EEG is unfamiliar to most neurologists, and its interpretation requires knowledge of the physiological markers of electrogenesis maturation. The purpose of this review was to provide health-care professionals in the neonatal intensive care unit with guidance on the more common normal maturational features of the neonatal EEG. A simplified layout with the essential elements of normal neonatal EEG is included.
Not Enough Money and Too Many Thoughts: Exploring Perceptions of Mental Health in Two Ugandan Districts Through the Mental Health Literacy Framework
Authors: Miller Amanda P. , Ziegel Leo , Mugamba Stephen , Kyasanku Emmanuel , Wagman Jennifer A. , Nkwanzi-Lubega Violet , Nakigozi Gertrude , Kigozi Godfrey , Nalugoda Fred , Kigozi Grace , Nkale James , Watya Stephen , Ddaaki William
Published: January 2021

Mental health disorders account for a heavy disease burden in Uganda. In order to provide culturally appropriate mental health prevention and treatment approaches, it is necessary to understand how mental health is conceptualized in the population. Three focus group discussions (FGDs) and 31 in-depth interviews (IDIs) were conducted with men and women aged 14 to 62 years residing in rural, urban, and semi-urban low-income communities in central and western Uganda to explore perceptions and knowledge of mental health. Interpretive thematic analysis was undertaken; results were organized through the lens of the mental health literacy framework. Environmental and societal stressors were identified as primary underlying causes of poor mental health. While participants recognized symptoms of poor mental health, gaps in mental health literacy also emerged. Mental health resources are needed in this setting and additional qualitative work assessing knowledge and attitudes toward mental health care seeking behavior can inform the development of acceptable integrated services.
The Cause of Mental Health Problem Among Urban Residents During the COVID-19 Outbreak: Implication for information Communication
Authors: Wolde Abraham Kebede
Published: January 2021

This study examined the causes of mental health problems among urban residents in Bahir Dar City Administration. To achieve the objectives, data were gathered from residents, psychologists, psychiatrists, and medical doctors through deep interviews. The qualitative analysis of the data gathered through interviews revealed that mental health problem is prevalent and linked with social, psychological, and economic factors and female and the adult population was disposed to the mental health problem than the remaining populations. Based on the findings conclusions and possible recommendations were also forwarded.