bluuebunny/crossref_metadata_2025 huggingface dataset:
The oral-lung microbiome dysbiosis: Unravelling its role in implications for chronic obstructive pulmonary disease (COPD) pathogenesis
Authors: Mithradas Nimisha , Sudhakar Uma , Shanmugapriya K , Jeddy Nadeem , Ram Shankar
Published: December 2024

Background:

The impact of the oral flora on the composition of the microbiome in the lungs is substantial in both healthy and diseased conditions, contributing significantly to its intricacy. There is mounting evidence from microbiological research that suggests a major ecological relationship between periodontitis, Chronic Obstructive Pulmonary Disease (COPD), and oral microecosystems. An association has been established between respiratory diseases and disruptions in the symbiotic equilibrium of the oral microbiome. This study aims to explore the intricate connections between oral health and lung microflora, particularly about the pathogenesis of COPD, and to highlight the implications for future research and clinical practice.

Materials and Methods:

Subgingival Plaque samples were collected from a total of 120 participants with 30 healthy Control (H group),30 Periodontitis with no COPD (P group), 30 COPD with periodontally healthy (COPD) and 30 individuals with COPD and Periodontitis (COPD+ P). All participants underwent evaluation of periodontal measurements like Pocket Depth (PD), Clinical loss of Attachment (CAL), Gingival Index (GI), and Plaque Index (PI) Bacterial DNA was extracted and quantified using Real-time polymerase chain reaction. Using the One-dimensional Analysis of Variance (ANOVA) and post-analysis test for multiple comparisons, the mean values of all the clinical parameters were analyzed among the four participant groups. Using the Pearson Correlation coefficient, the parameters were correlated.

Results:

Statistical relevant relation was shown among Probing Depth (PD), Clinical Loss of Attachment (CAL), Plaque Index (PI) and Gingival Index (GI) in the COPD+P group. Increased prevalence of Pa (Pseudomonas aeroginosa) seen among P group and COPD+P. A substantial inverse relationship was seen between the absolute levels of Pa, CAL, PI, and lung function measures (Fev1, Fev1/FVC).

Conclusion:

The importance of maintaining dental health in the prevention and treatment of respiratory disorders is highlighted by the relationships that exist between the oral microecosystem, oral hygiene, and respiratory pathologies. There is substantial potential to decrease the occurrence of respiratory illnesses by practicing good oral care and strategically managing the balance of the oral microbial flora. Therefore, future research efforts should prioritize the characterization of the precise impact of the oral microbiota on pulmonary health and use this knowledge towards developing innovative preventive and treatment measures targeted at combating respiratory infections and related diseases.
Mitosis – predicting primary tumour and metastatic lymph node behaviour and beyond in OSCC – A pilot study
Authors: Makarla Soumya , Bavle Radhika M. , Topajiche Satyajit
Published: December 2024

Background and Objectives:

In the evaluation of oral cancer, mitotic index/mitotic figures are of paramount importance in histopathology. The number of mitoses in tumour cells is directly proportional to the activity of the tumour cells. In this novel study, we evaluated the status of the mitotic figures found in the metastatic deposit of the lymph nodes in addition to the primary tumour. A great deal of significance is given to this parameter in the evaluation of progress of the primary tumours in a state of distant metastasis. Therefore, we propose to analyse the lymph node mitotic index (LMI) in metastatic deposits and its relation to the primary tumour by assessing the relation between primary: LN mitosis ratio (PLMR). This also can provide an insight into the concept of understanding the dynamic state of lymph node deposits in oral squamous cell carcinoma (OSCC).

Materials and Methods:

A total of 510 lymph nodes from 17 cases of surgically treated OSCC were analysed, of which 40 lymph nodes were found to be positive. These 40 lymph nodes were examined histopathologically for the presence of mitotic figures in ten randomly selected fields (x400) and compared to the mitotic activity of the primary tumour by two observers independently, along with other histopathological features. LMI and PLMR were further determined for these cases.

Observations and Results:

The mitotic index was significantly higher in the metastatic deposits than in the primary tumour (P = 0.004). A higher percentage of abnormal mitoses was observed in metastatic lymph nodes, but no statistical significance (P = 0.27) was found when compared with primary tumour. Statistically significant correlation (P = 0.001) was observed between abnormal mitoses (%) and presence of ECS as well as size of the metastatic deposits. The LMI ratio showed a high mitotic rate in close to 80% of the cases. PLMR showed 58–60% cases with mitotically more active lymph nodes.

Interpretation and Conclusion:

This study is the first of its kind, which examines a level further than the nature of the primary tumour. Mitotic index/numbers in lymph nodes (LMI) might be considered an important parameter to evaluate the disease spread, revealing the nature of transiently indolent and mitotically active metastatic lymph nodes. The PLMR adds a further dimension on the lymph node’s dynamic status in the progression of the disease.
Effect of varying tobacco habits on salivary flow rate, pH and taste perception
Authors: Gupta Pearl , Dave Aparna , Saluja Pulin , Arora Manpreet
Published: December 2024

Background:

Smoking and smokeless form of tobacco consumption is highly prevalent among the adult population worldwide. Tobacco use has an adverse effect on oral health. It may contribute to an impaired salivary flow rate and influence salivary pH and taste perception.

Aim:

To evaluate the effects of tobacco on salivary flow rate, salivary pH and taste perception.

Objective:

To evaluate salivary flow rate, pH and taste perception in tobacco chewers and tobacco smokers.

Materials and Method:

Sixty subjects were selected from the patients attending Dental OPD. Group A included 20 subjects who has the habit of chewing tobacco for a minimum period of 5 years. Group B included 20 subjects who has the habit of smoking tobacco for at least a period of 5 years. Group C included 20 healthy individuals who did not have habit of chewing or smoking tobacco, and they formed the control group.

Results:

On comparing salivary pH between tobacco chewers (Group A) and control group (Group C), it was observed that there was not much difference in salivary pH between the groups. The mean value of Group A (tobacco chewers) of salivary pH was calculated as 7.59 with 0.70 SD. For the control group (Group C), the mean value was obtained as 7.42 with 0.96 standard deviation. The independent t-test was applied, and the result was nonsignificant. Similarly, when SFR was evaluated, it was observed that the mean value for SFR of Group A was 1.75 with 0.71 SD, and for the control group, it was 1.51. There was no significant difference in pH between Group A and Group B. A significant reduction in taste perception was observed in smokers as compared to nonsmokers (P < 0.05). Smokers rated the intensity of all taste solutions lower than the nonsmokers.

Conclusion:

Frequent tobacco use impacts oral health, often unknown to the users. This study found altered perception of bitter taste in tobacco users. However, salivary pH and SFR showed minimal variation.
Immunomodulatory effects of Triphala and its constituents in oral squamous cell carcinoma and oral precancer
Authors: Dineshkumar Thayalan , Anandan Nirmala , Rajkumar Krishnan , Nandhakumar Indumathi
Published: December 2024

Oral squamous cell carcinoma shows increased occurrence in those who consume tobacco products, alcohol, betel quid, and areca nut, and is also considered to occur due to genetic alteration. Though there are numerous advancements in treatment, survival remains a question with late diagnosis. Hence, there are continuous inventions of new drugs. The introduction of Ayurveda in the therapy has paved the way for the longevity of the patients affected. One such introduction is the use of Triphala. The current study aims to review the anti-oxidant, anti-proliferative, anti-microbial, and apoptotic action of Triphala and thus evaluate the anti-cancer action of Triphala. A literature search was done, in various electronic databases and the data were extracted according to the predefined criteria. Original studies of 19 reports were included in the analysis. Nineteen (six studies with Triphala combination) In vitro/In vivo studies were included in this systematic review. The included study showed that Triphala effectively modulates the immune system. The effects included were anti-oxidative, immune modulation, anti-proliferative, tumor suppression, apoptotic effect, reversal of precancerous lesion, and anti-microbial action. The analyses also showed that there is no side effect of Triphala up to the recommended dosage. Triphala, is a nourishing supplement that is well-known in Ayurveda for its capacity to restore healthy tissues and promote aging gracefully through its properties such as anti-oxidant, ant-proliferative, anti-inflammatory, cytotoxic apoptotic, and immune-modulatory properties. Hence, Triphala can be a promising drug in the prevention and treatment of oral cancer.
ENDOGLIN (CD105): A marker of tumour vasculature for assessment of malignant potential of oral submucous fibrosis
Authors: Shetty Subraj , Pereira Treville , Tamgadge Sandhya , Kale Sandeep , Kamat Pooja , Kumar Sourab
Published: December 2024

Background:

Oral submucous fibrosis (OSMF) is a precancerous condition associated with the use of betel/areca nut in various forms. It is characterized by restricted mouth opening, tongue protrusion and cheek rigidity. Oral submucous fibrosis, is primarily prevalent among the people of the Indian subcontinent and it has been reported that about one third of the OSMF patients develop squamous cell carcinoma.

Endoglin (CD-105) is a hypoxia induced protein and a potential marker for activated endothelial cells which signify tumorigenic neoangiogenesis.

Aim:

To determine expression of CD105 and study relation of neoangiogenesis with the clinical staging and histopathological grading of oral submucous fibrosis.

Material and Method:

Immunohistochemical expression of CD105 was evaluated on forty nine (49) paraffin-embedded tissue sections of diagnosed cases of OSF and seven (7) control samples of healthy volunteers.

Results:

There were 13 cases in Stage A, 11 cases in Stage B, 13 cases in Stage C, and 12 cases in Stage D. There were 4 cases in Grade 1 (Very early), 19 cases in Grade 2 (Early), 19 cases in Grade 3 (Moderately advance) and 7 cases in Grade 4 (Advance).

Conclusion:

The present study was first immunohistochemical study to demonstrate MVD, MVP and MVAP with CD105 expression in OSMF cases. However, well-designed studies with larger sample size is required to validate CD105 as a reliable biomarker for malignant transformation in future research.
Estimation and Correlation of Clinical Significance of Lipoprotein (a) as a Risk Factor of Atherosclerotic Vascular Events in Elderly: A 1-year Cross-sectional Study in KLE’s Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi
Authors: Maladkar Yashoda Tushar , Kothiwale Veerappa Annasaheb
Published: December 2024

Introduction:

Lipoprotein (a) (Lp(a)) was identified as a variant of low-density lipoprotein (LDL) 40 years ago. Lp(a) consists of one LDL particle containing apoB-100 and one molecule of a large, highly polymorphic glycoprotein known as apo (a). The study aimed to evaluate and correlate the clinical significance of Lp(a) as a risk factor for atherosclerotic vascular events in the elderly population.

Materials and Methods:

This cross-sectional study was conducted among patients admitted in a tertiary care hospital for for 1 year. One hundred and forty-two study participants included in the study were divided into two groups atherosclerotic vascular event group (2 subgroups: Cardiovascular atherosclerotic vascular event subgroup and neurological atherosclerotic vascular event subgroup) and no atherosclerotic vascular event group. Detailed history, examination, and parameters such as serum Lp(a), serum high-density lipoproteins, LDL, total cholesterol, triglycerides, glycated hemoglobin, and creatinine were tested.

Results:

Among 142 study participants in the study, majority of study participants were male (n = 96, 67.6%). The mean age was 71.63 years. High Lp(a) levels were noted in 51.41% of study participants. High Lp(a) levels were seen in 56% of study participants in the cardiovascular atherosclerotic vascular event subgroup, 43.33% of study participants in the neurological atherosclerotic vascular event subgroup and 51.61% in no atherosclerotic vascular event group.

Conclusion:

Our study concludes that Lp(a) may not be used to infer any clinical significance, nor may it have any role to play as a risk factor for atherosclerotic vascular events in the elderly (age >65 years).
Evaluation of Effective Bond Strength of Composite Resin to Etched Dentin after Dentin Pretreatment: An In-vitro Study
Authors: Bilal Muhammed , Pasha Shiraz , Nair Arathi S.
Published: December 2024

Aims:

The aims of the study were to compare the deproteinizing effect of sodium hypochlorite, doxycycline, ethylenediaminetetraacetic acid (EDTA), and chitosan on effective shear bond strength of bonded composite resin to etched dentin.

Materials and Methods:

Forty extracted human maxillary premolars were taken, which were placed in a metal mold with acrylic resin. Teeth were divided into four groups according to the deproteinizing agents used, which are 5% NaOCl, 2% doxycycline, 17% EDTA, and 1% chitosan. Occlusal reduction of 1 mm below the dentin–enamel junction was done. Dentin deproteinizing agents were applied for 60 s and blot dried after acid etching. A universal dentin bonding agent was brushed and light cured. Cylindrical molds with composite resin were placed on the bonded surface and light cured. The shear bond strength was measured using a universal testing machine with a crosshead speed of 1.3 mm/min.

Statistical Analysis Used:

The Statistical Package for the Social Sciences (SPSS) for Windows, Version 22.0. released in 2013. Armonk, NY, USA: IBM Corp. was used to perform statistical analyses. One-way ANOVA test followed by Tukey’s Post hoc test was used to compare the mean shear bond strength between different groups.

Results:

Deproteinizing agent chitosan showed more bond strength compared to the other three agents used. Two percent doxycycline showed better shear bond strength followed by 5% NaOCl and 17% EDTA which had the least value for shear bond strength.

Conclusions:

Within the limitations of the present study, deproteinizing agents, when used after acid etching the dentin, can increase the bond strength. Chitosan showed to have a better deproteinizing effect compared to other agents used in the study.
Solitary fibrous tumor of the orbit: The importance of the histopathological diagnosis of the hemangiopericytoma pattern
Authors: Bertazzo Débora , Trottier Simon , Santos Carolina , Minussi Luiza Abreu , Marcotte Emily , Burnier Miguel Noel
Published: December 2024

Purpose:

The diagnoses of solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) have evolved over the past decades. Due to histopathological similarities, they were grouped as the same entity highlighting the complexity of this rare condition. Previous studies suggest that orbital HPC-pattern tumors are more aggressive than SFTs. We analyzed the histopathological and immunohistochemical features of patients with orbital SFT/HPC to further classify this entity.

Materials and Methods:

We reviewed eight orbital SFT/HPC cases from McGill University Health Centre (2011–2019). All of them were diagnosed as SFT, three with HPC pattern. Vascular proliferation (HPC) and spindle cell morphology (SFT) were evaluated. The tumors were stained with STAT6, CD34, Ki67, SMA, EMA, and S100 protein and further analyzed.

Results:

The average age was 49 years, and seven were male. Follow-up ranged from 6 to 96 months. Three patients (two males and one female) had an HPC pattern (average age of 54 years). Five male patients had only SFT pattern (average age of 46 years). In HPC cases, STAT6 was negative, CD34 and SMA were positive, S100 protein and EMA were negative, and Ki67 was low (5%–10%). In SFT cases, STAT6 and SMA were positive, CD34 was positive (in spindle cells and vessels for two cases, vessels only in three), S100 protein and EMA were negative, and Ki67 was low (5%–20%).

Conclusion:

These results highlight the pathological variability of orbital SFT/HPC. Immunohistochemical profiling helps differentiate between SFT and SFT with HPC pattern, which is essential, as HPC have a higher risk of recurrence and malignant transformation.
Gamification and healthcare volunteer motivation: A qualitative survey in the Asir region, Saudi Arabia
Authors: Alshehri Abdulrahman , Assiri Mousa , Hakami Khalid , Ali Zayed , Althbyani Sabah , Ibrahim Lamia , Almsaad Khlood , Leslie Wendy
Published: December 2024

Introduction:

Gamification, the application of game-like elements in nongame settings, has shown promise for increasing motivation across various sectors. However, their application in healthcare volunteering, particularly in Saudi Arabia, remains limited and understudied. Healthcare volunteers play a crucial role in service delivery; however, sustaining their motivation can be challenging.

Aims:

This study aimed to explore the effectiveness of gamification in enhancing motivation among healthcare volunteers in Saudi Arabia. Specifically, it examined the impact of gamification on situational motivation, distinguishing between intrinsic and extrinsic motivators, and assessed volunteers’ perceptions of the effectiveness of gamification.

Materials and Methods:

A cross-sectional mixed-methods design was used with a sample of 24 healthcare volunteers from a single organization in the Asir region. Participants completed pre- and postintervention surveys incorporating the Situational Motivation Scale (SIMS) and open-ended questions. The 4-week gamification intervention introduced elements such as points, badges, and leaderboards, to encourage engagement. Quantitative data were analyzed using descriptive statistics and paired-sample t-tests to assess changes in motivation levels, while thematic analysis was conducted on the qualitative responses.

Results and Discussion:

Preintervention data indicated generally high baseline motivation, with 54.2% of participants rating their motivation as highly motivated. The postintervention results revealed a statistically significant increase in intrinsic motivation (mean SIMS score: 6.53, standard deviation: 0.76), indicating that gamification positively influenced engagement. The thematic analysis highlighted core motivators, including skill development, community services, and personal growth. While participants appreciated gamification elements such as recognition and rewards, some raised concerns regarding fairness and the potential for competition to detract from the collaborative spirit. The findings suggest that gamification can effectively enhance both intrinsic and extrinsic motivation among healthcare volunteers, particularly when designed to align with their values and motivations. The study highlights the need for thoughtful implementation, ensuring that gamification supports rather than undermines the community-focused values prevalent in volunteer settings.

Conclusion:

This study demonstrates the potential of gamification as a viable tool for boosting motivation in healthcare volunteers, provided it is balanced by cultural and motivational factors. Healthcare organizations that consider gamification in volunteer management should prioritize fairness, transparency, and alignment with intrinsic values to foster sustainable engagement.
Patient satisfaction with services of private dental clinics in Riyadh city: A cross-sectional study
Authors: Alfahadi Hadi Rajeh , Alharbi Nouf Sahal , Alkazman Fawaz Hamad , Alabbas Mohsen S.
Published: December 2024

Introduction:

Patient satisfaction with health care describes the degree to which patients’ needs and expectations are met, and an acceptable level of service is provided. Additionally, it is also a measure of the quality of care that patients receive. Therefore, plays a major role in determining the relationship between the quality of healthcare services provided and patient confidence. It is important predictor of patient compliance, their ability to follow instructions, and their adherence to treatment, as well as for, determining their future use of health services. This is why patient satisfaction is increasingly considered as vital in assessing the general quality of care and thus in improving health services.

Aims:

This study set out to explore dental patients’ satisfaction with the service provided by private clinics in Riyadh in terms of accessibility, the availability and convenience of the facilities, cost, pain caused from dental procedures, the overall quality of treatment received, and the continuity of service.

Materials and Methods:

From January to February 2021, we conducted a cross-sectional study online survey of 420 patients to investigate their satisfaction the services provided by private dental clinics in Riyadh. Based on a previous questionnaire created by John, the online DSQ covered five key domains, namely, accessibility, cost, availability and convenience, pain, service quality, and additionally, overall level of satisfaction with the service. The resulting data were analyzed statistically using the SPSS-22 program and chi-square tests.

Results and Discussion:

The current study showed that, based on the demographics of the sample, among the five domains investigated, four were statistically significant as only the cost of dental procedures was not. Accessibility, availability, pain, and continuity were ranked highest among the younger participants and those with a lower educational level indicated greater pain from dental procedures. With regard to the quality of the dental service, again the youngest age group registered a higher level of satisfaction with the males taking the lead.

Conclusion:

The study showed that patient satisfaction with dental care is a valid measure of the quality of care and that having a service that meets the patients expected level of satisfaction should go a long way in helping to improve service delivery. Therefore, measuring the patients’ satisfaction with the service is an important factor in improving the service provided and so this should be done regularly.
Hot-Cracking Behaviors in (CoNi)85Mo15 Medium-Entropy Alloys Manufactured via Powder Bed Fusion
Authors: Nam Seungjin , Jung Heechan , Park Haeum , Jung Chahee , Park Jeong Min , Kim Hyoung Seop , Sohn Seok Su
Published: December 2024

Additive manufacturing makes it possible to improve the mechanical properties of alloys through segregation engineering of specific alloying elements into the dislocation cell structure. In this study, we investigated the mechanical and microstructural characteristics of CoNi-based medium-entropy alloys (MEAs), including the refractory alloying element Mo with a large atomic radius, manufactured via laser-powder bed fusion (L-PBF). In an analysis of the printability depending on the processing parameters, we achieved a high compressive yield strength up to 653 MPa in L-PBF for (CoNi)85Mo15 MEAs. However, severe residual stress remained at high-angle grain boundaries, and a brittle µ phase was precipitated at Mo-segregated dislocation cells. These resulted in hot-cracking behaviors in (CoNi)85Mo15 MEAs during L-PBF. These findings highlight the need for further research to adjust the Mo content and processing techniques to mitigate cracking behaviors in L-PBF-manufactured (CoNi)85Mo15 MEAs.
Can Mean Platelet Volume be an Inflammatory Marker in Pediatric Diabetic Ketoacidosis?
Authors: Trabzon Gül , Çiçek Dilek , Güngör Şükrü , Demiray Güllü Şeyma , Yazarlı Esra , Güllü Ufuk Utku , El Çiğdem
Published: December 2024

This study explores the association between mean platelet volume (MPV) and other hematological parameters in children with diabetic ketoacidosis (DKA), aiming to identify hematological changes and their implications for management and treatment strategies in pediatric type 1 diabetes mellitus (T1DM). In a retrospective, two-center analysis of 323 children, participants were categorized into three groups: DKA, T1DM without ketoacidosis, and healthy controls (95). Hematological parameters and HbA1c levels were collected. Blood pH levels classified DKA severity, and statistical analyses included One-way ANOVA, correlation tests, receiver operating characteristic curve analysis, and logistic regression to assess the predictive value of hematological parameters for DKA. No significant demographic differences were noted among the groups. Patients with DKA exhibited significantly lower MPV and higher neutrophil-to-lymphocyte ratio (NLR) compared with both patients with T1DM without ketoacidosis and healthy controls. Logistic regression showed MPV ≤9.35 and NLR ≥2.73 significantly increased DKA risk. This study demonstrated a significant relationship between DKA and altered hematological parameters (MPV and NLR) in pediatric patients, highlighting their potential as markers for early detection and risk assessment of DKA.
Challenges and Limitations of Terahertz Phase Imaging Method
Authors: Kaluza Mateusz , Nieradka Adrianna , Komorowski Paweł , Siemion Agnieszka
Published: December 2024

Advancements in terahertz (THz) technology have significantly enhanced imaging systems, while improving imaging contrast remains critical, especially for transparent objects. This study presents a 4f imaging system using the positive phase contrast method, tested on a transparent 3D-printed object with varying phase retardations. Parasitic effects observed during experiments highlight key challenges in THz imaging, enabling the identification of solutions to improve system performance and enhance image quality. Full Text: PDF References

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Claiming Indigenous Sovereignty Online
Authors: Tai Chun Chia
Published: December 2024

Taiwanese Indigenous youths utilize social media to assert Indigeneity. However, while egalitarian technologies provide a platform for self-representation, fetishism and multiculturalism might misrepresent their Indigeneity. This study focuses on Ponay’s covers of Mando-pop songs on YouTube to reclaim Indigenous popular music history and challenge Han-centric aesthetics and heteronormativity.
The Ecclesiastical Justice System in the Kingdom of Bohemia in the Middle Ages
Authors: Krafl Pavel
Published: December 2024

The study concentrates on the ecclesiastical courts that operated within the Prague ecclesiastical province. The episcopal judiciary in the Czech lands comprised the officialis, the vicar general, the corrector cleri, and the bishop's inquisitor. The officialis appears for the first time in the Diocese of Olomouc under Bishop Bruno of Schaumburg (1245–1281). The judicial office of the corrector cleri was a unique office that emerged only in Prague. The papal courts in the territory of the ecclesiastical province comprised the papal inquisitors and the conservators of rights. During the Hussite and post-Hussite era, the archbishopric of Prague was left unoccupied, and the judicial agenda was conducted to a limited extent by the administrators of the archbishopric. One of the criticisms made by pre-Hussite reform theorists was levelled at the negative features of the judiciary, particularly the corruption of judges and the absence of impartiality.
Svák Ján, Mareček Lukáš et al.: Medzinárodné právo verejné a úvod do verejného medzinárodného práva [Public International Law and Introduction to Public International Law]
Authors: Paľuchová Petra
Published: December 2024

In a rapidly changing world, international law often seems to recede into the background, overshadowed by domestic legal disciplines. Students tend to prioritise information that appears to have direct practical applicability, leading to a diminished focus on international law in favour of national legal frameworks. Given the overwhelming influx of information they encounter daily, it is perhaps natural for students to favour subjects they perceive as immediately relevant to practice, a relevance they do not always associate with international law. As a legal framework governing inter-state relations and international obligations, it may appear distant from the routine legal challenges they anticipate encountering in their professional careers. The understanding of peremptory norms, enforcement mechanisms, or the resolution of disputes between states may seem less pertinent, as their practice is unlikely to involve the regular handling of inter-state conflicts.
The perspective on the current state of international law is exemplified by the broad publication under review. The distinctiveness of this textbook is evident from the very beginning, which does not include merely a preface, acknowledgments, or an introduction preceding the main content. Instead, it begins with an "introduction to the introduction," explaining the intent to offer an unconventional approach to educating young legal professionals in international law. The aim is to present this expansive and omnipresent discipline as a clear and practical benefit, extending beyond the confines of academic study and serving as a unifying thread among various branches of law, civil, labour law, criminal law, commercial law and number of others, by emphasising the centrality of the individual as the ultimate recipient of all international legal norms. This focus on the individual, including legal professionals themselves, whether graduates or students for whom this publication is primarily intended as a resource for the courses International Public Law I and International Public Law II, underscores the need for a broader outlook. A lawyer, even after completing seminars on international law, should comprehend the extensive and pervasive reach of this discipline. They must, crucially, be equipped to address diverse and complex legal issues, many of which intersect with international law, at least through domestic legal norms that invariably reflect international legal principles to some extent and, even more concretely, in the respect for fundamental human rights.
Inheritance Rights of Children Born Out of Wedlock in the Perspective of Islamic Law
Authors: Pirdaus Dede Irman , AS Nurnisaa
Published: December 2024

This study aims to analyze the legal status of illegitimate children from the perspective of Islamic law and civil law in Indonesia, focusing on aspects of lineage, inheritance rights, and legal protection. This study uses a literature study method with descriptive-analytical analysis to compare regulations in Islamic law and positive law. In Islamic law, illegitimate children only have lineage and inheritance rights through the mother and her family, while in civil law, illegitimate children can obtain legal recognition from their parents through a process of recognition or a court decision. This study also highlights the role of the Constitutional Court Decision Number 46/PUU-VIII/2010 which provides further legal protection for illegitimate children, especially regarding civil rights. Although there are fundamental differences in the recognition of lineage and inheritance rights, both legal systems agree on the importance of protecting children's basic rights
Evaluation of Public Acceptance of Digital ID Cards: Legal and Technological Implications in Indonesian Public Administration
Authors: Lestari Mugi , Agung S M Panji
Published: December 2024

The implementation of a digital identity system in Indonesia, specifically through the introduction of digital ID cards, represents a significant milestone in the country's public administration. This policy aims to streamline administrative processes, enhance service access, and ensure more efficient management of citizen data. However, the shift to digital identities presents challenges related to personal data protection, technological infrastructure, and public acceptance. This study explores the implications of the digital identity policy, focusing on legal frameworks, public reception, and the protection of personal data. Using a qualitative approach, the study analyzes key findings from interviews, document reviews, and observations, highlighting critical issues such as the security of biometric data, the integration of digital identity systems across public services, and the public's understanding of digital rights. The study concludes with policy recommendations aimed at strengthening data protection laws, improving infrastructure in underserved areas, and fostering greater public awareness to ensure a successful transition to a digital identity system in Indonesia.
Efisiensi Game Edukasi Thermoquest Pada Materi Suhu Bagi Siswa Sekolah Menengah Pertama
Authors: Mazidah Isti'anatul , Saputro Sigit dwi
Published: December 2024

Pendidikan di era 4.0 berfokus pada keterampilan, kemampuan berpikir kritis, keterampilan pengambilan keputusan, dan kebutuhan untuk membekali peserta didik dengan keterampilan untuk mencari, meringkas, mengomunikasikan, dan menggunakan informasi dan teknologi secara efektif. sehingga diperlukan sebuah media pembelajaran yang memiliki performa yang optimal baik digunakan pada android maupun desktop. Sebuah penelitian telah dilakukan untuk mengembangkan permainan edukatif yang disebut "Thermoquest” pada materi suhu. Penelitian ini menggunakan metode pengembangan aplikasi serta eksperimen. Dengan menunjukan hasil uji coba menggunakan laboratorium, hasil pengujian dan evaluasi yang dilakukan terhadap aplikasi thermoquest, dapat disimpulkan bahwa aplikasi ini memiliki hasil uji coba yang dilakkukan menggunakan alat PageSpeed Insight menunjukkan bahwa aplikasi bekerja lebih optimal pada perangkat desktop 91. 75% dibandingkan pada perangkat mobile 87.5%.
Las variantes de autor: Manuel Villegas López y los manuscritos sobre la vida de John Sutter
Authors: Diez Puertas Emeterio
Published: December 2024

En 1941, el exiliado español Manuel Villegas López publicó en la Editorial Atlántida de Buenos Aires el libro Vida de Sutter, una biografía novelada sobre el pionero californiano Johann Augustus Sutter (1803-1880). Este tema ya había sido tratado por, entre otros, Blaise Cendrars, en su novela L’Or (1925), y Stefan Zweig, en uno de los episodios de Sternstunden der Menschheit (1927). Incluso había dado lugar en 1936 a dos películas: Sutter’s Gold y Der Kaiser von Kalifornien. Este artículo estudia las tres variantes de autor que sobre esta figura histórica escribió Villegas: la primera, de once capítulos, publicada en 1941; la segunda, de treinta y seis capítulos, cerrada en 1960 con la colaboración de su esposa, Remedios Zalamea Herrera, para un premio literario e inédita; y la tercera, de siete capítulos, firmada con un seudónimo, también inédita y sin fechar. Todos estos materiales se han encontrado en el Archivo Familiar, que guarda una parte del legado de Villegas. El propósito del artículo es utilizar el marco teórico y metodológico de la crítica textual aplicada al manuscrito moderno para descubrir las variantes: la más reciente, la que tiene más palabras, la mejor conservada o codex optimus y la editio princeps.
El viaje al origen es el final. Violencia y muerte en Tierra, novela de David Miklos
Authors: Rivero Quinto María del Carmen
Published: December 2024

Origen y muerte distinguen la poética de David Miklos. En Tierra, su novela más reciente, el autor suma la violencia como motivo literario de un viaje en la modalidad de desplazamiento forzado. El artículo analiza el tratamiento de la narrativa de viajes a través de sus elementos constitutivos y sostiene que la violencia modifica sus razones pues, mientras el tiempo del relato avanza, el tiempo vital de los personajes se consume. Así, Miklos resignifica el sentido del concepto heideggeriano ser para la muerte en un contexto ficcional que narra la actual realidad social mexicana.
THE ENORMOUS POTENTIAL OF JOB CRAFTING BEHAVIOR: A CONCEPTUAL PAPER BASED ON REGULATORY FOCUS
Authors: Ishaq Rabeea , Ali Syed , Ul Ain Noor
Published: December 2024

This paper explores the theoretical review of job crafting behavior in service organizations by reviewing the literature on innovation capabilities. A workforce with proactive traits faces less environmental restriction and shows more groundbreaking behaviors of novel change. The current study has moved its emphasis from the influence of organizational job design on worker consequences to the inspection of the part that the workforce plays in defining task, social, and cognitive limits of work to verify innovation. Thus, innovation change is sighted as the exploitation of novelty that entails alterations in work tasks for positive outcomes. This conceptual paper discusses the roles of innovation capabilities and job-crafting behavior in the IT industry. Refereeing to the theory of regulatory focus, the main objective of this paper is to create a new conceptual framework to understand the influence of employees’ perception of innovation capabilities by underpinning the regulatory focus model on job crafting behavior in the IT industry.
INSTITUTIONAL QUALITY AND ECONOMIC PERFORMANCE ASSESSMENT: EVIDENCE FROM NIGERIA
Authors: Joshua OJO , Osobase Anthony , Matthew Ochada
Published: December 2024

The assessment of institutional quality and its influence on economic performance is highly relevant in Nigeria due to the country's constantly changing governmental institutions, dynamic market circumstances, and diversified socioeconomic atmosphere. Thus, the study aims to investigate the impact of institutional quality on the economic performance of Nigeria. This study employed ex post facto research, while time series data was used, which spans from 1996 to 2021, sourced from the Central Bank of Nigeria (CBN) and the Worldwide Governance Indicators (WGI). The study employed unit root tests, Johansen cointegration, and the Error Correction Model as estimation techniques. However, post estimation tests such as normality, serial correlation, heteroskedasticity and stability tests were carried to ascertain the level of statistical accuracy outcome of the variables used. The findings suggest that there is a sustained nexus between the quality of institutions and characteristics related to economic growth. Also, it was equally found out that political stability has a significant impact in the short run. This suggests that a unit increase in political instability would definitely amount to a decrease in economic performance in Nigeria during the period under investigation. The study suggests enhancing accountability, transparency, administrative efficiency, and law adherence to improve Nigerian institutions. This can be achieved through reform implementation, capacity building, and good governance mechanisms, while reducing political unrest and fostering stability.
EXPORT-LED GROWTH: TRADE POLICY PROSPECTIVE OF PAKISTAN
Authors: Ahmed Rafiq , Iqbal Muhammad , Akhter Faheem
Published: December 2024

This study examines the proposition that exports cause growth in gross domestic product GDP in the economy of Pakistan from 1973 to 2022. The study intends to analyze the export promotion strategy that was adopted by Pakistan's economy in the 1990s. Cointegration test reveals there is a long-run relationship between these two variables. However, causality is proved in both short and long-run from GDP to exports. The Trade openness and export growth both are prolonged association but in case of Pakistan persistent depreciation of PKR could not achieve desired level of export earning which implies that J-Curve theory does not exist in Pakistan.  This implies that growth in the domestic production base is vital to expansion in exports. The government or policymakers should give importance to and incentivize various production sectors of an economy so that they can contribute to the expansion of export markets.
In silico DOCKING STUDIES OF BIOACTIVE COMPOUNDS IN CHLOROFORM EXTRACT OF Annona muricata LEAVES AGAINST HUMAN ANDROGEN RECEPTOR
Authors: Ikpa C. B. C. , Ikezu U. J. M.
Published: December 2024

It has become a major challenge for clinicians and research scientists to control or treat prostate inflammation due to drug resistance being commonly observed. Crude extracts from medicinal plants could serve as an alternative source for resistance-modifying agents because they contain numerous diverse secondary metabolites. It has been claimed that Anonna muricata possess anti-inflammatory, antioxidant, anticancer and antibacterial activities. However, little is still known about the bioactive compounds responsible for this activity. In this study, the plant`s bioactive compounds were extracted using chloroform and analyzed with Gas Chromatography-Mass Spectrometry (GC–MS). The drug likeness and ADME predictions were done with Swissadme webserver, while the molecular docking against human androgen receptor was done using Auto dock Vina. The docking results showed that the binding energy and interactions of 9,12-Octadecadienoic acid (Z,Z)- (-6.7kcal/mol); 1,2-Benzenedicarboxylic acid, butyl octyl ester (-6.1) and 8-Hexadecenal, 14-methyl-, (Z)- (6.1kcal/mol) ) were close to the control drug enzalutamide (-7.6 kcal/mol) and the protein native ligand methyltrienolone (-7.4kcal/mol). More so, these compounds showed drug likeness by obeying the limpiski rule qualifying them to be good drug candidate for control or treatment of prostate inflammations.
Stressor and Job Stress Among Nurse Educators in Bangladesh
Authors: Akter Amena , Mallick Dipali Rani , Begum Taslima , Islam Md. Shariful
Published: December 2024

Background: Job stress is a common feature in the teaching profession, and it has been increasing daily among nurse educators due to stressors. Objectives: The study's main aim was to examine the relationship between stressors and job stress among nurse educators in Bangladesh. Methods: A descriptive correlation study was conducted among nurse educators at Dhaka Nursing College, College of Nursing Mohakhali, and College of Nursing Sher-E-Bangla Nagar, Dhaka, from January to December 2023. A convenience sampling technique was used to select the participants. A sample size of 102 was determined using power analysis. The instruments used for this study were the Teacher Stress Inventory (TSI) developed by Fimian (1984), comprising 49 items with ten subscales. Data were collected through a self-administered structured questionnaire and analyzed with descriptive and inferential statistics. Results: This study results showed that nurse educators experienced high stress in the subscale of stressors, including work-related stressors (M=3.03, SD=.71), professional distress (M=4.26, SD=.64), discipline and motivation (M=3.48, SD=1.07) and professional investment (M=4.03, SD=.90). On the other hand, nurse educators mentioned not noticing stress symptoms in all subscales of job stress including emotional manifestation (M=2.16, SD=1.09), fatigue manifestation (M=2.27, SD=.84), cardiovascular manifestation (M=2.01, SD=1.21), gastronomical manifestation (M=1.54, SD=.59), and behavioral manifestation (M=1.53, SD=.65). However, there was a significant relationship between stressors and job stress (r=.200, p=.045) among the nurse educators. Conclusion: Nurse Educators experienced high stress at the workplace due to stressors, but job stress was not manifested. This result will help the higher authorities of nursing colleges & nurse educators recognize different workplace stressors to develop stress reduction strategies for preventing adverse health effects.
A updated review of Acalypha indica L. as traditional/Ethnomedicinal plant and its pharmacological activities
Authors: T. Sivakumar
Published: December 2024

Acalypha indica L., is an vital Indian medicinal plant and is broadly used in Traditional/Ethnomedicinal, Ayurveda, and Siddha to manage various diseases. It has a wide range of chemical constituents, pharmacological and medicinal applications. Various pharmacological tests have been carried out both in vitro and in vivo and phytoconstituents of medical importance have been identified. Many biological components in good yield and some mainly belonging to cyanogenic glucoside (acalyphin), tannins, flavonoids, pyranoquinolinone alkaloid (flindersin) have been shown to have beneficial biological activities. The extracts and chemical constituents of this plant have useful pharmacological activities. The key pharmacological activities of Acalypha indica are antivenom property and antiobecity activity. Several pharmacological studies of Acalypha indica have demonstrated their antioxidant, antimicrobial, antidiabetic, and antivenom in support of its traditional uses. Suggest a wide range of medicinal uses for cathartic, diuretic, anthelmintic, emetic, expectorant treatment. Therefore, this review contributes to the knowledge of Acalypha indica plant and their Traditional and ethnomedicinal use..
Historia Secreta: mitologías conspirativas en los documentales de Brasil Paralelo
Authors: Felinto Erick
Published: December 2024

Este trabajo tiene como objetivo analizar los elementos y articulaciones de un imaginario conspirativo presente en el documental "Pátria Educadora", producido por el canal de streaming Brasil Paralelo. Mi hipótesis principal es que este imaginario debe ser investigado no sólo en el nivel semántico de los significados producidos en el discurso audiovisual, sino también en la dimensión de las atmósferas que actúan como adjuntos a este discurso. Se propone que este análisis tenga lugar en la interfaz entre los campos de los estudios políticos, teorías del afecto y las tecnologías de la comunicación.