bluuebunny/crossref_metadata_2025 huggingface dataset:
App helps patients through yearlong post‐treatment recovery
Authors: Knopf Alison
Published: March 2019

A new app designed by people in recovery themselves is designed to reduce relapse rates. The app, called WEConnect, operates on cellphones. There is GPS location that confirms the patient's attendance at therapy or meetings. And treatment providers can use outcomes data to maintain their certification with the Joint Commission, according to the company, which is based in Seattle.
LAC to HHS: Don't weaken patient privacy, strengthen it
Authors: Knopf Alison
Published: March 2019

The Legal Action Center (LAC) is urging the federal government not to weaken patient privacy, but rather, to strengthen it. The December 2018 request for information (RFI) from the Department of Health and Human Services (HHS) cited “regulatory burdens” of the Health Insurance Portability and Accountability Act (HIPAA) (see ADAW, Jan. 21). Ironically, the forces that want to kill 42 CFR Part 2, the confidentiality regulation that applies only to substance use disorder (SUD) treatment records and requires individualized written consent by the patient before records can be released, want to make that regulation more like HIPAA.
A Dynamic Graphene Oxide Network Enables Spray Printing of Colloidal Gels for High‐Performance Micro‐Supercapacitors
Authors: Xiong Zhiyuan , Yun Xiawei , Qiu Ling , Sun Youyi , Tang Bo , He Zijun , Xiao Jing , Chung Dwayne , Ng Tuck Wah , Yan Hao , Zhang Ranran , Wang Xiaogong , Li Dan
Published: March 2019

Properly controlling the rheological properties of nanoparticle inks is crucial to their printability. Here, it is reported that colloidal gels containing a dynamic network of graphene oxide (GO) sheets can display unusual rheological properties after high‐rate shearing. When mixed with polyaniline nanofiber dispersions, the GO network not only facilitates the gelation process but also serves as an effective energy‐transmission network to allow fast structural recovery after the gel is deformed by high‐rate shearing. This extraordinary fast recovery phenomenon has made it possible to use the conventional air‐brush spray technique to print the gel with high‐throughput and high fidelity on nonplanar flexible surfaces. The as‐printed micro‐supercapacitors exhibit an areal capacitance 4–6 times higher than traditionally spray‐printed ones. This work highlights the hidden potential of 2D materials as functional yet highly efficient rheological enhancers to facilitate industrial processing of nanomaterial‐based devices.
Stressing the Role of DNA as a Drug Carrier: Synthesis of DNA–Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides
Authors: Guo Yuanyuan , Zhang Jiao , Ding Fei , Pan Gaifang , Li Jing , Feng Jing , Zhu Xinyuan , Zhang Chuan
Published: March 2019

To stress the role of deoxyribonucleic acid (DNA) as a drug carrier, an efficient conjugation strategy in which chemotherapeutics can be grafted onto a phosphorothiolated DNA backbone through the reaction between the phosphorothioate group (PS) and a benzyl bromide group is proposed. As a proof of concept, benzyl‐bromide‐modified paclitaxel (PTX) is employed to graft onto the DNA backbone at the PS modification sites. Due to the easy preparation of phosphorothiolated DNA at any desired position during its solid‐phase synthesis, diblock DNA strands containing both normal phosphodiester segment (PODNA) and phosphorothiolate segment (PSDNA) are directly grafted with a multitude of PTXs without using complicated and exogenous linkers. Then, the resulting amphiphilic PODNA‐blocked‐(PSDNA‐grafted PTX) conjugates (PODNA‐b‐(PSDNA‐g‐PTX)) assemble into PTX‐loaded spherical nucleic acid (SNA)‐like micellar nanoparticles (PTX‐SNAs) with a high drug loading ratio up to ≈53%. Importantly, the PODNA segment maintains its molecular recognition property and biological functions, which allows the as‐prepared PTX‐SNAs to be further functionalized with tumor‐targeting aptamers, fluorescent probe strands, or antisense sequences. These multifunctional PTX‐SNAs demonstrate active tumor‐targeting delivery, efficient inhibition of tumor growth, and the reversal of drug resistance both in vitro and in vivo for comprehensive antitumor therapy.
Emergence of an Antiferromagnetic Mott Insulating Phase in Hexagonal π‐Conjugated Covalent Organic Frameworks
Authors: Thomas Simil , Li Hong , Bredas Jean‐Luc
Published: March 2019

While the search for 2D organic semimetallic Dirac materials displaying, like graphene, a Dirac cone at the Fermi level remains active, attention is also being paid to the quantum phase transition from semimetal to antiferromagnet. Such a transition in graphene‐like materials is predicted based on theoretical investigations of the 2D honeycomb lattice; it occurs (within a Hubbard model) when the on‐site electron–electron Coulomb repulsion (U) is much larger than the nearest‐neighbor inter‐site electronic coupling (t). Here, monomers carrying long‐lived radicals are considered and used as building blocks to design 2D hexagonal π‐conjugated covalent organic frameworks (COFs). Both the nonmagnetic semimetallic phase and magnetically ordered phases are evaluated. It is found that the electronic coupling between adjacent radical centers in these COFs is more than an order of magnitude smaller than in graphene while the on‐site Coulomb repulsion is reduced to a lesser extent. The resulting large U/t ratio drives these COFs into the antiferromagnetic side of the phase diagram. This work provides a first theoretical evidence of the realization of an antiferromagnetic Mott insulating phase in 2D π‐conjugated COFs and allows a strategy to achieve quantum phase transitions from antiferromagnet to spin liquid and to semimetal to be outlined.
An Ultra‐Mechanosensitive Visco‐Poroelastic Polymer Ion Pump for Continuous Self‐Powering Kinematic Triboelectric Nanogenerators
Authors: Hwang Hee Jae , Kim Joo Sung , Kim Wook , Park Hyunwoo , Bhatia Divij , Jee Eunsong , Chung Yoon Sun , Kim Do Hwan , Choi Dukhyun
Published: March 2019

A mechanosensitive, visco‐poroelastic polymer ion pump that can rapidly establish a dense electrical double layer via mechanical pressure, thereby significantly enhancing output performance of an ionic triboelectric nanogenerator (iTENG), is described. A working mechanism of an iTENG using a highly mechanosensitive, visco‐poroelastic ion pump is suggested and the optimal characteristics of the polymer ion pump are reported by investigating optical, mechanical, electrical, and electrochemical properties. Surprisingly, the pressure sensitivity of the iTENG reaches 23.3 V kPa−1, which is tens of times the record value. To achieve controlled high‐frequency pulses from an iTENG, kinematic systems using a gear train and a cam are integrated with a single grounded iTENG, which produces a maximum of 600 V and 22 mA (≈2.2 W cm−2) at an input frequency of 1.67 Hz; after power transforming, those values are converted to 1.42 V and 225 mA. A capacitor of 1 mF can be fully charged to 2 V in only 60 s, making it possible to continuously operate a wireless‐communicating self‐powered humidity sensor. Also, due to the high transparency and deformability of the polymer ion pump, a self‐powered transparent tactile sensor is successfully assembled using a 5 × 5 iTENG array.
Child and Family Team Meeting Characteristics and Outcomes in a Statewide System of Care
Authors: Schreier Alayna , Horwitz Mark , Marshall Tim , Bracey Jeana , Cummins Mary , Kaufman Joy S.
Published: March 2019

Systems of care (SOC) have relied on the wraparound care process to individualize community‐based services for children and youth with serious emotional and behavioral difficulties. A core element of wraparound care is Child and Family Team meetings (CFTs), which are designed to give youth and families a leadership role in developing and guiding their plan of care. The National Wraparound Initiative (NWI) has identified Practice Standards regarding CFT implementation. This study examined CFT characteristics and the association between those characteristics and youth and family outcomes in a statewide SOC. Participants were 363 youth (Mage = 10.89, SD = 3.72) and their caregivers. Families completed measures of youth and caregiver functioning and symptoms at enrollment and 6‐month follow‐up. Care coordinators completed a survey assessing CFT implementation and characteristics following each meeting. Multiple regression analyses were used to examine the relationship between CFT characteristics and youth and caregiver outcomes. Results indicated that a higher number of CFTs was associated with poorer outcomes, while a higher percentage of natural supports at meetings was associated with better youth outcomes. Number of days to the first CFT was associated with greater caregiver strain. Implications for CFT implementation within wraparound are discussed.
Genotype and phenotype correlation in 103 individuals with 2q37 deletion syndrome reveals incomplete penetrance and supports HDAC4 as the primary genetic contributor
Authors: Le Trang N. , Williams Stephen R. , Alaimo Joseph T. , Elsea Sarah H.
Published: March 2019

The 2q37 deletion syndrome, also described in the literature as brachydactyly‐mental retardation syndrome (MIM 600430), is caused by deletion or haploinsufficiency of the HDAC4 gene, which encodes the histone deacetylase 4 protein. Although the most commonly described hallmark features of the 2q37 deletion syndrome include brachydactyly type E, developmental delay, obesity, autistic features, and craniofacial or skeletal dysmorphism, a literature review of 101 published cases plus two newly reported individuals indicates that there is a high degree of variability in the presence of some of the features that are considered the most characteristic of the syndrome: overweight and obesity (34%), cognitive‐behavioral issues (79%), dysmorphic craniofacial features (86%), and type E brachydactyly (48%). These features overlap with other neurodevelopmental conditions, including Smith‐Magenis syndrome (SMS), and may be incompletely penetrant or demonstrate variable expressivity, depending on the specific chromosomal anomaly. With the advent of fluorescence in situ hybridization (FISH), array‐based comparative genomic hybridization, and next‐generation DNA sequencing, more detailed molecular diagnoses are possible than in years past, enabling refined characterization of the genotype–phenotype correlation for subjects with 2q37 deletions. In addition, investigations into molecular and gene expression networks are expanding in neurodevelopmental conditions, and we surveyed HDAC4 downstream gene expression by quantitative real‐time polymerase chain reaction, further implicating HDAC4 in its role in the regulation of RAI1. Correlation of clinical data defining the impact on downstream gene expression and the potential clinical associations across neurodevelopment will improve our understanding of these complex conditions and potentially lead to common therapeutic approaches.
One‐Pot Synthesis of Indoles from Aniline and α,β‐Ynones through an Iodine‐Mediated Transition‐Metal‐Free Tandem aza‐Michael addition/C−H Functionalization
Authors: Su Jie , Zhang Kan , Zhuang Mengyuan , Ma Fuyu , Zhang Wei‐Qiang , Sun Huaming , Zhang Guofang , Jian Yajun , Gao Ziwei
Published: March 2019

An efficient iodine‐mediated aza‐Michael addition/C−H functionalization procedure for the synthesis of indoles was achieved in one pot. By simple aza‐Michael addition between anilines and α,β‐ynones, a series of N‐aryl enaminones intermediate was generated, followed by iodine‐mediated C−H functionalization, a wide variety of indole derivatives were obtained in moderate to excellent yields under transition‐metal‐free conditions. Control experiments and in situ ESI‐MS analysis indicated the reaction occurred via a radical mechanism.
Sagittal suture maturation: Morphological reorganization, relation to aging, and reliability as an age‐at‐death indicator
Authors: Nikolova Silviya , Toneva Diana , Georgiev Ivan , Lazarov Nikolai
Published: March 2019

Objectives

The sagittal suture (SS) is assumed to be an initial site for the commencement of cranial suture closure as well as the most frequent spot of isolated craniosynostosis. The present study aimed to inspect the reorganization of the SS at the microlevel to assess the relation between its closure and aging and to establish whether it could be used as a reliable indicator in age‐at‐death prediction.

Materials and methods

The SS was investigated in 68 dry contemporary adult male skulls of known age‐at‐death. An additional series of 20 skulls was used for verification. The skulls were scanned using a micro‐computed tomography system. The SS closure degree was assessed along the three bone layers on cross‐sectional tomograms by using a scoring scale.

Results

In the entirely open SS, the bone edges consist of compact bone and are widely separated. With SS maturation, the bone edges come into contact, and the remodeling process leads to a decrease in the sutural area and bone homogenization across all three layers. SS closure is an irregular process roughly related to aging, beginning in the early 20s, reaching its peak at about 30 years of age and abating in the late 40s.

Discussion

Although related to aging, SS closure is not a simple function of it. Rather, the underlying factors inducing and managing this process are multifaceted and complex. Although the etiology of SS maturation remains unclear, it is reasonable to use SS closure cautiously and only as a supportive method for age prediction.
Control Mechanism for Carbon‐Chain Length in Polyunsaturated Fatty‐Acid Synthases
Authors: Hayashi Shohei , Naka Mai , Ikeuchi Kenshin , Ohtsuka Makoto , Kobayashi Kota , Satoh Yasuharu , Ogasawara Yasushi , Maruyama Chitose , Hamano Yoshimitsu , Ujihara Tetsuro , Dairi Tohru
Published: March 2019

Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are essential fatty acids. PUFA synthases are composed of three to four subunits and each create a specific PUFA without undesirable byproducts. However, detailed biosynthetic mechanisms for controlling final product profiles have been obscure. Here, the bacterial DHA and EPA synthases were carefully dissected by in vivo and in vitro experiments. In vitro analysis with two KS domains (KSA and KSC) and acyl‐acyl carrier protein (ACP) substrates showed that KSA accepted short‐ to medium‐chain substrates while KSC accepted medium‐ to long‐chain substrates. Unexpectedly, condensation from C18 to C20, the last elongation step in EPA biosynthesis, was catalyzed by KSA domains in both EPA and DHA synthases. Conversely, condensation from C20 to C22, the last elongation step for DHA biosynthesis, was catalyzed by the KSC domain in DHA synthase. KSC domains therefore determine the chain lengths.
Alkylaluminum activator effects on polyethylene branching using a N,N′‐nickel precatalyst appended with bulky 4,4′‐dimethoxybenzhydryl groups
Authors: Yuan Shifang , Duan Ting , Zhang Randi , Solan Gregory A. , Ma Yanping , Liang Tongling , Sun Wen‐Hua
Published: March 2019

Ten unsymmetrical N,N'‐bis (imino) acenaphthene‐nickel (II) halide complexes, [1‐[2,6‐{(4‐MeOC6H4)2CH}2–4‐MeC6H2N]‐2‐(ArN)C2C10H6]NiX2, each appended with one N‐2,6‐bis(4,4'‐dimethoxybenzhydryl)‐4‐methylphenyl group, have been synthesized and characterized. The molecular structures of Ni1, Ni3, Ni5 and Ni6 highlight the variation in steric protection afforded by the inequivalent N‐aryl groups; a distorted tetrahedral geometry is conferred about each nickel center. On activation with diethylaluminum chloride (Et2AlCl) or methylaluminoxane (MAO), all complexes showed high activity at 30°C for the polymerization of ethylene with the least bulky bromide precatalysts (Ni1 and Ni4), generally the most productive, forming polyethylenes with narrow dispersities [Mw/Mn: < 3.4 (Et2AlCl), < 4.1 (MAO)] and various levels of branching. Significantly, this level of branching can be influenced by the type of co‐catalyst employed, with Et2AlCl having a predilection towards polymers displaying significantly higher branching contents than with MAO [Tm: 33.0–82.5°C (Et2AlCl) vs. 117.9–119.4°C (MAO)]. On the other hand, the molecular weights of the materials obtained with each co‐catalyst were high and, in some cases, entering the ultra‐high molecular weight range [Mw range: 6.8–12.2 × 105 g mol−1 (Et2AlCl), 7.2–10.9 × 105 g mol−1 (MAO)]. Furthermore, good tensile strength (εb up to 553.5%) and elastic recovery (up to 84%) have been displayed by selected more branched polymers highlighting their elastomeric properties.
Synergistic effect of graphene oxide and sodium carboxymethylcellulose on the properties of poly(vinyl alcohol) hydrogels
Authors: Xue Fei , He Xianru , Cai Shuwei , Nie Jun , Shi Zhengren , Wang Xin
Published: March 2019

Hydrogels are a promising candidate for applications in biomedicine and bioengineering, but their mechanical properties often restrict their applications. To improve the mechanical performance of poly(vinyl alcohol) (PVA) hydrogels, we introduced sodium carboxymethylcellulose (CMC), and graphene oxide (GO) into them. We prepared a series of composite hydrogels composed of PVA, CMC, and GO with epichlorohydrin as a chemical crosslinker. We used Fourier transform infrared spectroscopy and X‐ray diffraction to characterize the chemical structures of GO and the hydrogel. The dynamic mechanical analysis results show the synergistic enhancement effects of CMC and GO on the PVA hydrogel. The swelling process of the hydrogels also fit well with the second‐order kinetic equation. Scanning electron microscopy results suggest that the neat mesh structure facilitated superior mechanical properties in the hydrogels. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47644.
Rheological behavior and flow instability in capillary extrusion of ultrahigh‐molecular‐weight polyethylene/high‐density polyethylene/nano‐SiO2 blends
Authors: Liu Lichao , Zhao Hang , Wang Fei , Xue Ping , Tian Jing
Published: March 2019

Rheological behaviors of ultrahigh‐molecular‐weight polyethylene (PE)/high‐density PE/SiO2 blends are investigated using parallel‐plate rheometer and capillary rheometer. The molecular chain conformational change mechanism is used to explain flow instabilities during extrusion. The viewpoints are proposed: (1) critical shear rate depends on the relative strength of irreversible viscous loss and reversible elastic orientation for molecular chains in transverse velocity gradient field inside the die and (2) critical shear stress depends on the extent of molecular chain conformational change inside the die, and the ease of conformational recovery after leaving the die. Modified nano‐SiO2 particles are detected a certain interfacial adhesion in PE matrix. The interfacial interaction limits viscous flow inside the die and conformational recovery after leaving the die, thus causing not only the flow instabilities to occur prematurely on shear rate and delaying sharkskin on shear stress, but also an alternate “sharkskin‐melt fracture” appearance after global extrusion fracture. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47713.
Preparation of polyurethane ionomers by reactive extrusion and dispersions containing sulfonate groups and polyethylene glycol segments
Authors: Wu Guofei , Sun Dongcheng
Published: March 2019

A synthesis method of polyurethane ionomers (PUIs) and anionic/nonionic polyurethane dispersions (PUDs) is introduced in this article. PUIs were synthesized in twin‐screw extruder without organic solvent. PUIs were then dissolved in acetone and dispersed in water. The PUDs were obtained after distilling off acetone and the solid content of PUDs was about 55% and had excellent stability. PUDs obtained were mainly used as adhesives. PUIs were synthesized from poly(1,4‐butylene adipate glycol) (PBA) as soft segments, 1,4‐butanediol (BDO) and diphenylmethane diisocyanate‐50 (MDI‐50) as hard segments, poly(ethylene glycol) methyl ether (MPEG) and polyether diol‐containing sulfonate (SPPG) as hydrophilic monomers, and dibutyltin dilaurate (DBTDL) as catalyst. The particle size, viscosity, and adhesive properties of the PUDs were measured and the results indicated that PUDs obtained have excellent stability and adhesive properties, such as the maximum initial peel strength and T‐peel strength were 2.38 and 11.82 N mm−1, respectively. The thermal properties, tensile stress–strain, and water resistance of the PUIs films were also characterized. The test results showed that films have good thermal properties and water resistance properties, and some typical characteristics of crystalline polymers were revealed in the tensile stress–strain curves. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47719.
Treatment to Target Using Recombinant Interleukin‐1 Receptor Antagonist as First‐Line Monotherapy in New‐Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five‐Year Follow‐Up Study
Authors: ter Haar Nienke M. , van Dijkhuizen E. H. Pieter , Swart Joost F. , van Royen‐Kerkhof Annet , el Idrissi Ayman , Leek Arjen P. , de Jager Wilco , de Groot Mark C. H. , Haitjema Saskia , Holzinger Dirk , Foell Dirk , van Loosdregt Jorg , Wulffraat Nico M. , de Roock Sytze , Vastert Sebastiaan J.
Published: March 2019

Objective

Systemic juvenile idiopathic arthritis (JIA) is a multifactorial autoinflammatory disease with a historically poor prognosis. With current treatment regimens, approximately half of patients still experience active disease after 1 year of therapy. This study was undertaken to evaluate a treat‐to‐target approach using recombinant interleukin‐1 receptor antagonist (rIL‐1Ra; anakinra) as first‐line monotherapy to achieve early inactive disease and prevent damage.

Methods

In this single‐center, prospective study, patients with new‐onset systemic JIA with an unsatisfactory response to nonsteroidal antiinflammatory drugs received rIL‐1Ra monotherapy according to a treat‐to‐target strategy. Patients with an incomplete response to 2 mg/kg rIL‐1Ra subsequently received 4 mg/kg rIL‐1Ra or additional prednisolone, or switched to alternative therapy. For patients in whom inactive disease was achieved, rIL‐1Ra was tapered after 3 months and subsequently stopped.

Results

Forty‐two patients, including 12 who had no arthritis at disease onset, were followed up for a median of 5.8 years. The median time to achieve inactive disease was 33 days. At 1 year, 76% had inactive disease, and 52% had inactive disease while not receiving medication. High neutrophil counts at baseline and a complete response after 1 month of rIL‐1Ra were highly associated with inactive disease at 1 year. After 5 years of follow‐up, 96% of the patients included had inactive disease, and 75% had inactive disease while not receiving medication. Articular or extraarticular damage was reported in <5%, and only 33% of the patients received glucocorticoids. Treatment with rIL‐1Ra was equally effective in systemic JIA patients without arthritis at disease onset.

Conclusion

Treatment to target, starting with first‐line, short‐course monotherapy with rIL‐1Ra, is a highly efficacious strategy to induce and sustain inactive disease and to prevent disease‐ and glucocorticoid‐related damage in systemic JIA.
Strong f‐f Excitation and Bright Red Emission in Cd4Gd1‐xEuxO(BO3)3 (0≤x≤1): Near‐UV LED Pumped Red Phosphor with Low Thermal Quenching
Authors: Yin Chao , Yue Mufei , Jiang Pengfei , Yang Ruirui , Zhou Xianju , Gao Wenliang , Cong Rihong , Yang Tao
Published: March 2019

Searching efficient red phosphors under near‐UV or blue light excitation is practically important to improve the current white light‐emitting diodes (WLEDs). Eu2+‐ and Mn4+‐based red phosphors have been extensively studied. Here we proposed that Eu3+ is also a promising activator when it resides on a noncentrosymmetric coordination site. We proved that Cd4GdO(BO3)3 is a good host, which has a significantly distorted coordination for Eu3+. A careful crystallographic study was performed on the solid solutions of Cd4Gd1‐xEuxO(BO3)3 (0≤x≤1) by Rietveld refinements. The as‐doped Eu3+ cations locate at the Gd3+ site and are well separated by CdO8, CdO6 and BO3 groups; thus, only a slight concentration quenching was observed at ≈80 atom % Eu3+. Most importantly, the parity‐forbidden law of 4f‐4f transitions for Eu3+ are severely depressed, thus the absorptions at ≈393 and ≈465 nm are remarkable. Cd4Gd0.2Eu0.8O(BO3)3 can be pumped by a 395 nm LED chip to give a bright red emission, and when mixed with other commercial blue and green phosphors, it can emit the proper white light (0.3657, 0.3613) with a suitable Ra≈87 and correlated colour temperature ≈4326 K. In‐situ photoluminescence study indicated the low thermal quenching of these borate phosphors, especially under 465 nm excitation. Our case proves the practicability to develop near‐UV excited red phosphors in rare‐earth‐containing borates.
ALFABET 2.0: Datengrundlage zur DIN EN 1999‐1‐3
Authors: Rengstl Mathias , Radlbeck Christina , Mensinger Martin
Published: March 2019

Im Zuge eines AiF‐Forschungsprojekts (IGF‐18629) zur Ermüdung von Aluminiumkonstruktionen im Kurzzeitfestigkeitsbereich, d. h. wenige Lastwechsel bei hoher Spannungsschwingbreite, wurde am Lehrstuhl für Metallbau der TU München die Datengrundlage der DIN EN 1999‐1‐3 zum Großteil rekonstruiert. Ziel war es, die Versuchshintergründe zu den Kerbdetails und ihren Bemessungslinien neu zu organisieren und für eine statistische Auswertung aufzubereiten. Die ursprüngliche Datenbank ALFABET aus dem Jahr 1990 war nicht mehr lauffähig und wurde dementsprechend lange nicht mehr gepflegt. Die original implementierten Versuchsdaten lagen aber noch auszugweise in damals exportierten Formularen vor. Auf dieser Basis wurde die Datenbank ALFABET 2.0 neu erstellt und mit weiteren Versuchsdaten ergänzt. Aktuell stehen ca. 2 500 Ermüdungsversuche zu Grundmaterial, Verbindungen und Trägerversuchen aus dem Zeitraum 1960–2018 zur Verfügung. Der Schwerpunkt von damaligem und heutigem Aufbau der Datenbank liegt vor allem auf der Beurteilung des Einflusses von Kerben und der Mittelspannung auf die Ermüdungsfestigkeit. Die möglichst breit angelegte Versuchsbasis dient letztlich zur Ableitung von normativ abgesicherten Bemessungslinien.
Enhancing corporate sustainable development: Stakeholder pressures, organizational learning, and green innovation
Authors: Zhang Feng , Zhu Lei
Published: March 2019

Green innovation has become the main path toward achieving corporate sustainable development. Despite the centrality of organizational learning in firms pursuing green activities, little research has considered its role in the relationship between stakeholder pressures and green innovation. By combining stakeholder theory and organizational learning theory, this study explores whether environmental pressures from different stakeholders influence green innovation differently and how this is further mediated by organizational learning. From a sample of 259 Chinese manufacturing firms, we find that consumer pressure has a greater positive effect on green product innovation than regulation pressure, whereas regulation pressure is more positively related to green process innovation than consumer pressure. Moreover, these two relationships are partially mediated by exploration learning and exploitation learning, respectively. These findings advance the existing research on the stakeholder pressures–green innovation linkage by revealing that consumer and regulation pressures influence green product innovation and green process innovation differently and through different organizational learning approaches.
Neurological examination of the infant
Authors: Salandy Sonja , Rai Rabjot , Gutierrez Santiago , Ishak Basem , Tubbs R. Shane
Published: March 2019

Clinicians are required to perform neurological examinations on infants to ensure they meet developmental milestones. A full neurological examination includes evaluating motor and sensory function, assessing the status of the cranial nerves, testing primitive reflexes, and atypical responses to further evaluate any developmental pathologies. The difficulty in maintaining infants' cooperation requires resourcefulness on the clinician's part to understand what is being tested and in what way to complete the examination. This literature will provide clinicians with guidance on the way to conduct a thorough neurological examination of infants. Clin. Anat. 32:770–777, 2019. © 2019 Wiley Periodicals, Inc.
Learn how Tulane's recent OCR agreement could impact single‐sex programs
Authors: Rooksby Jacob H.
Published: March 2019

Discussions of inequality in higher education naturally bring to mind groups that have historically been underrepresented or discriminated against in terms of access to and equity in education. But men aren't often the topic of these discussions. Congressional testimony surrounding the passage of Title IX in 1972 indicates that lawmakers were particularly concerned about the inequitable treatment of women (not men) in higher education, and indeed early enforcement efforts under Title IX tended to focus on unequal access to educational experiences for women, including most notably in athletics programs.
Long‐term molecular remission in a patient with acute myeloid leukemia harboring a new NUP98‐LEDGF rearrangement
Authors: Gallego Hernanz Maria Pilar , Torregrosa Diaz José Miguel , Sorel Nathalie , Bobin Arthur , Dindinaud Elodie , Bouyer Sabrina , Desmier Deborah , Brizard Françoise , Leleu Xavier , Maillard Natacha , Chomel Jean‐Claude
Published: March 2019

A large variety of molecular rearrangements of the NUP98 gene have been described in the past decades (n = 72), involving fusion partners coding for different transcription factors, chromatin modifying enzymes, as well as various cytosolic proteins. Here, we report the case of an AML‐M2 patient with a variant NUP98‐LEDGF/PSIP1 gene fusion (N9‐L10). In this patient, three different NUP98-LEDGF fusion mRNAs were characterized due to alternative splicing in LEDGF exon 11. Targeted high‐throughput sequencing revealed the presence of IDH1, SRSF2, and WT1 additional pathogenic mutations. To improve the therapeutic monitoring, quantification of NUP98‐LEDGF mRNA by real‐time PCR was developed. Because of poor response to conventional chemotherapy, allogeneic stem cell transplantation was performed, followed by 20 cycles of azacitidine‐based preemptive treatment of relapse. More than 31 months after diagnosis, corresponding to 25 months post SCT and 4 months after the last cycle of azacytidine, the patient is in complete molecular remission (undetectable NUP98‐LEDGF mRNA transcripts). This study highlights the considerable variability in breakpoint location within both NUP98 and LEDGF, associated with alternative splicing affecting LEDGF. It also emphasizes the need to fully characterize the breakpoints within the two genes and the identification of all fusion mRNAs, particularly for the development of a molecular monitoring assay. All these data seem critical for the optimal management of NUP98‐LEDGF + hematological malignancies commonly associated with a poor prognosis.
Impact of molecular testing in clinical practice in gynecologic cancers
Authors: Huang Marilyn , Hunter Tegan , Slomovitz Brian , Schlumbrecht Matthew
Published: March 2019

Background

With the growing understanding of the molecular and genetic profiles of cancers, targeted treatments are increasingly utilized in personalized cancer care. The objective of this study was to determine how these advances have translated into practice by examining how often molecular profiling of gynecological tumors led to treatment changes.

Methods

We identified women with gynecological cancers at our institution who had molecular tumor testing performed from November 2014 to June 2017. Clinicopathologic data were extracted from medical records. We determined (a) if molecular profiling identified actionable targets for which therapy is available, and (b) whether the patient's treatment course changed as a result of molecular profiling. Chi‐square, Wilcoxon rank‐sum, and Fisher's exact tests were used with a P < 0.05 considered statistically significant.

Results

We identified 152 patients with gynecologic cancers who underwent molecular profiling. Of the 152 patients, 116 (76.3%) had actionable mutations identified, with 41 (35.3%) patients having a treatment change. Stratified by cancer type, molecular profiling most frequently identified an actionable target in patients with endometrial cancer (73.6%). Changes in treatment occurred most frequently in patients with endometrial cancer, 22 (56.4%), and ovarian cancers, 16 (39%), as compared to patients with cervical and vulvar cancer (P = 0.02). Of those patients who received a change in treatment, 39 patients (95.1%) received an FDA‐approved therapeutic agent, while two patients (4.8%) were enrolled in a clinical trial.

Conclusion

Molecular profiling in gynecologic cancers often identified at least one actionable mutation; however, only in a minority of these cases was the course of treatment changed. Further studies are needed to elucidate optimal timing for testing to best utilize actionable information.
Psychiatric, reproductive, and relationship health in adolescent and young adult women
Authors: Terkell Shannon
Published: March 2019

The intersection between adolescent mental and reproductive health and relationship violence is a significant but sometimes under‐recognized aspect of the treatment of adolescents in psychiatric settings. References to teen pregnancy and relationship violence can be found everywhere from Tupac to Thomas Hardy. However, treatment and intervention related to reproductive health, psychiatric illness, and relationship consent in young women, and accessing resources and supports for these patients, remains challenging. While this article aims to address factors in recognizing and treating reproductive and relationship health in adolescents and young women, it is worth noting that young men are also vulnerable to sexual and relationship violence, and that abusive or coercive behaviors by adolescents in relationships may also be addressed in treatment. The following case description illustrates several factors in the treatment of adolescent and young adult women with psychiatric illness and concerns related to reproductive health and relationship safety.
Individualized Career Counseling Outcome Assessment: A Case Study Using the Personal Questionnaire
Authors: Cardoso Paulo , Sales Célia M. D.
Published: March 2019

Career counseling has evolved to include practices that attribute a central importance to context variables and meaning‐making processes. Accordingly, there is a need for client assessment tools that consider the subjectivity and cultural specificity of clients and the interface between their work and life concerns. The idiographic assessment of outcomes, which uses individualized measures that involve clients in the definition of person‐specific items, is a promising approach. This article explores the use of the Personal Questionnaire (PQ) as an individualized outcome measure that complements standardized outcome career measures. The authors identify the factors leading to the emergence of idiographic assessment in career counseling, review existing research relevant to the need for the PQ, and present a case study of career construction counseling that illustrates how the PQ helps counselors to obtain sensitive and contextualized assessments of career counseling outcomes, guides interventions, and facilitates meaning making.
Counselor Education and Supervision: 2017 Inaugural Review
Authors: Minton Casey A. Barrio
Published: March 2019

This article includes a review of 100 peer‐reviewed journal articles regarding counselor education and supervision published in 2017. Areas reviewed include supervision, understanding stakeholders, teaching and training, and professional issues. Publications featured a blend of research methodologies, attention to complexity in supervision and teaching, and incorporation of student experiences.
Reprocessing of a mining waste deposit in the Harz mountains – How contaminated sites might become raw material deposits in the future
Authors: Römer Felix , Goldmann Daniel
Published: March 2019

Derzeit steigt durch das weltweite Wachstum und Umweltbewusstsein das Interesse an der Rückgewinnung von knappen Rohstoffen aus anthropogenen Ablagerungen. Weitere Motive sind neben dem Rohstoffhunger der modernen Welt das Flächenrecycling und die Gefahrenabwehr. Der Bergeteich Bollrich ist eine feuchte Ablagerung von Aufbereitungsrückständen aus dem Bergbau mit hohen Wertstoffanteilen. In diesem Beitrag wird eine in dem Forschungsprojekt REWITA entwickelte Aufbereitungsroute zur Rückgewinnung verschiedener Rohstoffe bei gleichzeitiger Reduktion von Schadstoffen und des Rückstands vorgestellt. Die Hauptverfahren sind Flotation, Laugung und ionenselektive Anreicherung.
Applying queue theory for modeling of cloud computing: A systematic review
Authors: Jafarnejad Ghomi Einollah , Rahmani Amir Masoud , Qader Nooruldeen Nasih
Published: March 2019

The cloud computing paradigm is an important service in the Internet for sharing and providing resources in a cost‐efficient way. Modeling of a cloud system is not an easy task because of the complexity and large scale of such systems. Cloud reliability could be improved by modeling the various aspects of cloud systems, including scheduling, service time, wait time, and hardware and software failures. The aim of this study is to survey research studies done on the modeling of cloud computing using the queuing system in order to identify where more emphasis should be placed in both current and future research directions. This paper follows the goal by investigating the articles published between 2008 and January 2017 in journals and conferences. A systematic mapping study combined with a systematic literature review was performed to find the related literature, and 71 articles were selected as primary studies that were classified in relation to the focus, research type, and contribution type. We classified the modeling techniques of cloud computing using the queuing theory in seven categories based on their focus area: (1) performance, (2) quality of service, (3) workflow scheduling, (4) energy savings, (5) resource management, (6) priority‐based servicing, and (7) reliability. A majority of the primary articles focus on performance (37%), 15% of them focus on resource management, 14% of them focus on quality of service, 13% of them focus on workflow scheduling, 13% of them focus on energy savings, 4% of them focus on priority‐based servicing for requests, and 4% of them focus on reliability. This work summarizes and classifies the research efforts conducted on applying queue theory for modeling of cloud computing (AQTMCC), providing a good starting point for further research in this area.
Transferable HMM probability matrices in multi‐orientation geometric medical volumes segmentation
Authors: AlZu'bi Shadi , AlQatawneh Sokyna , ElBes Mohammad , Alsmirat Mohammad
Published: March 2019

Acceptable error rate, low quality assessment, and time complexity are the major problems in image segmentation, which needed to be discovered. A variety of acceleration techniques have been applied and achieve real time results, but still limited in 3D. HMM is one of the best statistical techniques that played a significant rule recently. The problem associated with HMM is time complexity, which has been resolved using different accelerator. In this research, we propose a methodology for transferring HMM matrices from image to another skipping the training time for the rest of the 3D volume. One HMM train is generated and generalized to the whole volume. The concepts behind multi‐orientation geometrical segmentation has been employed here to improve the quality of HMM segmentation. Axial, saggital, and coronal orientations have been considered individually and together to achieve accurate segmentation results in less processing time and superior quality in the detection accuracy.
Pd‐Catalyzed Stereodivergent Allylic Amination of α‐Tertiary Allylic Alcohols towards α,β‐Unsaturated γ‐Amino Acids
Authors: Xie Jianing , Qiao Chang , Martínez Belmonte Marta , Escudero‐Adán Eduardo C. , Kleij Arjan W.
Published: March 2019

Tertiary allylic alcohols were conveniently converted into either (Z)‐ or (E)‐configured α,β‐unsaturated γ‐amino acids by treatment with secondary amines under Pd catalysis at ambient conditions. The key to control the stereochemical course of these formal allylic aminations was the presence of a suitable diphosphine ligand, with dppp [1,3‐bis(diphenylphosphino)propane, L12] providing high yields and selectivities for the (Z) isomers, whereas the bis[(2‐diphenylphosphino)phenyl]ether (DPEPhos) derivative L1′ allowed for selective formation of the corresponding (E) isomeric products. This ligand‐controlled, stereodivergent protocol thus shows promise for the stereoselective preparation of allylic amine products from a common substrate precursor.
Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations
Authors: Mikubo Masashi , Maruyama Raito , Kakinuma Hirokuni , Yoshida Tsutomu , Satoh Yukitoshi
Published: March 2019

Ciliated muconodular papillary tumors (CMPTs) of the lung are rare, likely benign neoplastic lesions. Here we describe a case of a CMPT, focusing on its cytologic features, which to our knowledge have not been reported previously. Owing to dull back pain, a 69‐year‐old male non‐smoker underwent CT, which revealed a 1.3 × 1.3‐cm solid nodule in the peripheral field of the left lower lung lobe. A wedge resection of the nodule was performed, with the provisional diagnosis being primary lung cancer. Macroscopic examination of a resected specimen showed a 1.2‐cm grayish nodule. Touch imprint smear cytology revealed ciliated columnar cells and mucous cells, as well as abundant extracellular mucin on inflammatory background of lymphocytes and histiocytes. Histologic examination revealed a nodular papillary tumor composed of ciliated columnar cells, mucous cells, and basal cells surrounded by a mucin pool. No nuclear atypia or mitotic figures were identified. The final diagnosis was CMPT. The postoperative course was uneventful, with no recurrence at 8 months after surgery. Although a CMPT is a rare lung tumor, it should be considered when cytological or histological examination of a solitary peripheral lung nodule shows non‐atypical ciliated cells and mucous cells surrounded by mucin.
Phylogeographic patterns and conservation implications of the endangered Chinese giant salamander
Authors: Liang Zhi‐Qiang , Chen Wei‐Tao , Wang Deng‐Qiang , Zhang Shu‐Huan , Wang Chong‐Rui , He Shun‐Ping , Wu Yuan‐An , He Ping , Xie Jiang , Li Chuan‐Wu , Merilä Juha , Wei Qi‐Wei
Published: March 2019

Understanding genetic diversity patterns of endangered species is an important premise for biodiversity conservation. The critically endangered salamanderAndrias davidianus, endemic to central and southern mainland in China, has suffered from sharp range and population size declines over the past three decades. However, the levels and patterns of genetic diversity ofA. davidianuspopulations in wild remain poorly understood. Herein, we explore the levels and phylogeographic patterns of genetic diversity of wild‐caughtA. davidianususing larvae and adult collection with the aid of sequence variation in (a) the mitochondrial DNA (mtDNA) fragments (n = 320 individuals; 33 localities), (b) 19 whole mtDNA genomes, and (c) nuclear recombinase activating gene 2 (RAG2;n = 88 individuals; 19 localities). Phylogenetic analyses based on mtDNA datasets uncovered seven divergent mitochondrial clades (A–G), which likely originated in association with the uplifting of mountains during the Late Miocene, specific habitat requirements, barriers including mountains and drainages and lower dispersal ability. The distributions of clades were geographic partitioned and confined in neighboring regions. Furthermore, we discovered some mountains, rivers, and provinces harbored more than one clades.RAG2analyses revealed no obvious geographic patterns among the five alleles detected. Our study depicts a relatively intact distribution map ofA. davidianusclades in natural species range and provides important knowledge that can be used to improve monitoring programs and develop a conservation strategy for this critically endangered organism.
Nondestructive inspection of sinterability of ceramic tiles by terahertz spectroscopy
Authors: Niijima Seiji , Shoyama Masashi , Kawase Kodo
Published: March 2019

The sinterability of ceramic tiles was evaluated using terahertz (THz) time‐domain spectroscopy. The transmittance, complex refractive index, and reflectance of the ceramic tiles fired at various temperatures were measured in frequency range of 0.3‐1.2 THz. The relation between these THz properties and their sinterability were examined. The firing‐temperature dependences of the refractive index and reflectance at 0.5 THz showed a similar behavior as that shown by the bulk density. These results show that the THz spectroscopy can be applied to nondestructive inspection of the sinterability of ceramic tiles.
How climate affects extreme events and hence ecological population models
Authors: Rypkema Diana C. , Horvitz Carol C. , Tuljapurkar Shripad
Published: March 2019

Extreme events significantly impact ecosystems and are predicted to increase in frequency and/or magnitude with climate change. Generalized extreme value (GEV) distributions describe most ecologically relevant extreme events, including hurricanes, wildfires, and disease spread. In climate science, the GEV is widely used as an accurate and flexible tool over large spatial scales (>105 km2) to study how changes in climate shift extreme events. However, ecologists rarely use the GEV to study how climate change affects populations. Here we show how to estimate a GEV for hurricanes at an ecologically relevant (<103 km2) spatial scale, and use the results in a stochastic, empirically based, matrix population model. As a case study, we use an understory shrub in southeast Florida, USA with hurricane‐driven dynamics and measure the effects of change using the stochastic population growth rate. We use sensitivities to analyze how population growth rate is affected by changes in hurricane frequency and intensity, canopy damage levels, and canopy recovery rates. Our results emphasize the importance of accurately estimating location‐specific storm frequency. In a rapidly changing world, our methods show how to combine realistic extreme event and population models to assess ecological impacts and to prioritize conservation actions for at‐risk populations.
Stille Expands the Family: Access to 5,6‐Bis‐2‐thienyl‐Substituted Phenanthroline Under Mild Conditions for Luminescent Ruthenium Complexes
Authors: Brückmann Jannik , Heidecker Alexandra Annabella , Popovic Duško , Mengele Alexander Klaus , Nauroozi Djawed , Bäuerle Peter , Rau Sven
Published: March 2019

The Stille coupling method was used to functionalize the 5‐ and 6‐positions of 1,10‐phenanthroline with thiophene substituents. Photophysical investigations of 5,6‐bis(5‐methylthien‐2‐yl)‐1,10‐phenanthroline showed a marked influence of the substituents on the absorption properties, as a bathochromic shift of 50 nm regarding the π–π* transitions was observed. The contribution of the substituents in the corresponding Ru complex, in turn, was negligible on the absorption properties of the compound, while the extinction coefficient for the complex dropped by a factor of 0.5 compared to reference complexes. Structural investigation of the ligand and the complex revealed a perpendicular orientation of the thiophene groups with respect to the phenanthroline plane, while no preferred conformation of sulfur atoms (parallel or antiparallel) could be observed. The newly synthesized complex exhibits a superior photostability relative to [Ru(bpy)3]2+, which is promising for future applications.