bluuebunny/crossref_metadata_2025 huggingface dataset:
Thrombophilia testing for whom, why and when – a review of current practices
Authors: Kariyawasan C. C. , Gunawardena D.
Published: April 2024

Thromboembolic conditions have accounted for 1 in 4 deaths worldwide in 2010. Thrombosis, which is the common pathogenesis of myocardial infarction, ischaemic stroke, and venous thromboembolism (VTE), is the leading cause of death (1/5 deaths in 1990). Hospital-acquired VTE accounts for approximately 60 percent of all VTEs annually. Others include cancer-associated thrombosis and gender associated risks. In addition to the disease burden, it also causes a significant economic burden world-wide. Multiple diagnostic tests and treatment, prolonged hospital stay and follow-up care, including management of recurrent VTE can be extremely costly. Therefore, it is important to focus on VTE prevention so that health care systems can save money, improve outcomes and save lives. In this background, it is important to have a clear direction as to when, how and whom to test for thrombophilia. Testing for thrombophilias is often performed without a clear understanding of the clinical implications of such results. Guidelines vary in the appropriate use of thrombophilia testing. In this review, these variations in thrombophilia testing and the implications mentioned in the recent guidelines and other articles are discussed. The review of such guidelines, guidance statements, review articles conclude that screening for hereditary thrombophilia has very limited advantage in the management of patients with thrombosis. Screening for antiphospholipid syndrome (APLS) is more important given its high rate of recurrence in both venous and arterial thrombosis. Screening for underlying haematological conditions such as myeloproliferative neoplasms (MPN) and paroxysmal nocturnal haemoglobinuria (PNH) is also considered important.
Proteolytic system parameters in the brain of rats with hyperhomocysteinemia
Authors: Synelnyk Tatyana , Raksha Nataliia , Kostiuk Oleksandra , Kharchenko Olga , Rymsha Sofia , Korol Viktoria , Korol Anatoliy , Bernyk Oksana , Maievskyi Oleksandr
Published: April 2024

Hyperhomocysteinemia (HHcy) is now being actively studied as a potential risk factor and/or biomarker for numerous pathological conditions, including brain diseases. This study aimed to analyze the proteolytic processes in the brains of rats with HHcy. Total proteolytic activity, metal-dependent, and serine proteases activities, the content of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases-1, cytokines, serine proteases, total protein and medium and low molecular-weight substances (MLMWS), were evaluated. HHcy was induced by DL-homocysteine thiolactone (HTL) daily intragastric administration (200 mg·kg–1 of body weight) to young and adult albino non-linear male rats for 8 weeks following rat sacrifice and brain harvesting. It was established that HHcy causes an increase in total proteolytic activity and a rise in MLMWS levels in rat brains. Serine protease activity increased to a greater extent compared to metal-dependent one, and bigger changes were observed in young rats. Rise in MMP-9 and -10 levels (in young animals), a decline in MMP-3 and -8 levels, and a decrease in the content of interleukin-1β, interferon-γ, interleukin-4 and tumor necrosis factor-α (the last two in young animals) was also detected. No significant changes were found in serine protease content. Therefore, proteolysis intensification in the brain of rats with HHcy is more likely caused by protease up-regulation through mechanisms stimulated by homocysteine, HTL, and oxidative stress, without involving pro-inflammatory signaling pathways.
Smoking cessation among tuberculosis patients during the coronavirus disease-2019 pandemic
Authors: Coutinho Sandra Eugênia , Lima de Braga Raimunda Sinthia , Santos André Külzer , Velho Joanna Scopel , Rossato Silva Denise
Published: April 2024

Smoking has been recognized as a significant risk factor for COVID-19 and mortality. The World Health Organization (WHO) has recommended smoking cessation to reduce the impact of COVID-19. This study aimed to evaluate the smoking cessation rate of patients starting tuberculosis (TB) treatment at six months using motivational interviewing based on the WHO "five steps to quit" model. In addition, we assessed the knowledge about smoking and the barriers to smoking cessation. We conducted a retrospective cohort study. Outpatients aged >18 years, smokers, and those who are starting TB treatment in two outpatient TB clinics were invited to participate. Patients received information about the importance of smoking cessation, especially in TB patients, and standardized advice based on guidelines. This information was repeated during phone calls during the second and fourth months of treatment. During the study period, 111 patients were included. The primary outcome was the smoking cessation rate at the end of the sixth month of treatment, which was 26.8% (19/71). The barriers to smoking cessation described by the patients were anxiety/depression (47.4%), seeing someone smoking (38.5%), drug use (19.2%), and alcohol abuse (2.6%). The assessment of knowledge about smoking showed that patients had some information gaps. In conclusion, TB smokers who tried to quit smoking during the COVID-19 pandemic faced many challenges. Despite this, we demonstrated a reasonable smoking cessation rate with a nurse-conducted motivational interview.
Black Kite status in Emilia-Romagna: an update
Authors: Pavesi Alessandro , Ravagnani Andrea
Published: April 2024

The aim of this work is to update the status of the Black Kite Milvus migrans in Emilia-Romagna region, reporting new data about nesting attempts, winter observations and major summer gatherings collected during the period 2006-2022.
Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
Authors: Ai Cheng-Jin , Chen Ling-Juan , Guo Li-Xuan , Wang Ya-Ping , Zhao Zi-Yi
Published: April 2024

BACKGROUND

Leukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional therapies. Gossypol acetic acid (GAA), which is extracted from the seeds of cotton plants, exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting Bcl2.

AIM

To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact mechanism.

METHODS

In this study, LSCs were magnetically sorted from AML cell lines and the CD34+CD38- population was obtained. The expression of leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) and forkhead box M1 (FOXM1) was evaluated in LSCs, and the effects of GAA on malignancies and mitochondrial function were measured.

RESULTS

LRPPRC was found to be upregulated, and GAA inhibited cell proliferation by degrading LRPPRC. GAA induced LRPPRC degradation and inhibited the activation of interleukin 6 (IL-6)/janus kinase (JAK) 1/signal transducer and activator of transcription (STAT) 3 signaling, enhancing chemosensitivity in LSCs against conventional chemotherapies, including L-Asparaginase, Dexamethasone, and cytarabine. GAA was also found to downregulate FOXM1 indirectly by regulating LRPPRC. Furthermore, GAA induced reactive oxygen species accumulation, disturbed mitochondrial homeostasis, and caused mitochondrial dysfunction. By inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC, GAA resulted in the elimination of LSCs. Meanwhile, GAA induced oxidative stress and subsequent cell damage by causing mitochondrial damage.

CONCLUSION

Taken together, the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.
Subclinical hepatitis E virus genotype 1 infection: The concept of “dynamic human reservoir”
Authors: Shrestha Ananta , Basnet Suresh , KC Sudhamshu
Published: April 2024

Hepatitis E virus (HEV) is hyperendemic in South Asia and Africa accounting for half of total Global HEV burden. There are eight genotypes of HEV. Among them, the four common ones known to infect humans, genotypes 1 and 2 are prevalent in the developing world and genotypes 3 and 4 are causing challenge in the industrialized world. Asymptomatic HEV viremia in the general population, especially among blood donors, has been reported in the literature worldwide. The clinical implications related to this asymptomatic viremia are unclear and need further exploration. Detection of viremia due to HEV genotype 1 infection, apparently among healthy blood donors is also reported without much knowledge about its infection rate. Similarly, while HEV genotype 3 is known to be transmitted via blood transfusion in humans and has been subjected to screening in many European nations, instances of transmission have also been documented albeit without significant clinical consequences. Epidemiology of HEV genotype 1 in endemic areas often show waxing and waning pattern. Occasional sporadic occurrence of HEV infection interrupted by outbreaks have been frequently seen. In absence of known animal reservoir, where HEV exists in between outbreak is a mystery that needs further exploration. However, occurrence of asymptomatic HEV viremia due to HEV genotype 1 during epidemiologically quiescent period may explain that this phenomenon may act as a dynamic reservoir. Since HEV genotype 1 infection cannot cause chronicity, subclinical transient infection and transmission of virus might be the reason it sustains in interepidemic period. This might be the similar phenomenon with SARS COVID-19 corona virus infection which is circulating worldwide in distinct phases with peaks and plateaus despite vaccination against it. In view of existing evidence, we propose the concept of “Dynamic Human Reservoir.” Quiescent subclinical infection of HEV without any clinical consequences and subsequent transmission may contribute to the existence of the virus in a community. The potential for transmitting HEV infection by asymptomatic HEV infected individuals by fecal shedding of virus has not been reported in literature. This missing link may be a key to Pandora's box in understanding epidemiology of HEV infection in genotype 1 predominant region.
Spectrum of COVID-19 induced liver injury: A review report
Authors: Singh Lokjan , Kumar Anil , Rai Maya , Basnet Bibek , Rai Nishant , Khanal Pukar , Lai Kok-Song , Cheng Wan-Hee , Asaad Ahmed Morad , Ansari Shamshul
Published: April 2024

The coronavirus disease 2019 (COVID-19) pandemic has caused changes in the global health system, causing significant setbacks in healthcare systems worldwide. This pandemic has also shown resilience, flexibility, and creativity in reacting to the tragedy. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection targets most of the respiratory tract, resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some individuals. Although the lung is the primary organ targeted by COVID-19 viruses, the clinical aspect of the disease is varied and ranges from asymptomatic to respiratory failure. However, due to an unorganized immune response and several affected mechanisms, the liver may also experience liver cell injury, ischemic liver dysfunction, and drug-induced liver injury, which can result in respiratory failure because of the immune system’s disordered response and other compromised processes that can end in multisystem organ failure. Patients with liver cirrhosis or those who have impaired immune systems may be more likely than other groups to experience worse results from the SARS-CoV-2 infection. We thus intend to examine the pathogenesis, current therapy, and consequences of liver damage concerning COVID-19.
Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis
Authors: Tang Xiao-Wei , Ren Wen-Sen , Huang Shu , Zou Kang , Xu Huan , Shi Xiao-Min , Zhang Wei , Shi Lei , Lü Mu-Han
Published: April 2024

BACKGROUND

Liver cirrhosis patients admitted to intensive care unit (ICU) have a high mortality rate.

AIM

To establish and validate a nomogram for predicting in-hospital mortality of ICU patients with liver cirrhosis.

METHODS

We extracted demographic, etiological, vital sign, laboratory test, comorbidity, complication, treatment, and severity score data of liver cirrhosis patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) and electronic ICU (eICU) collaborative research database (eICU-CRD). Predictor selection and model building were based on the MIMIC-IV dataset. The variables selected through least absolute shrinkage and selection operator analysis were further screened through multivariate regression analysis to obtain final predictors. The final predictors were included in the multivariate logistic regression model, which was used to construct a nomogram. Finally, we conducted external validation using the eICU-CRD. The area under the receiver operating characteristic curve (AUC), decision curve, and calibration curve were used to assess the efficacy of the models.

RESULTS

Risk factors, including the mean respiratory rate, mean systolic blood pressure, mean heart rate, white blood cells, international normalized ratio, total bilirubin, age, invasive ventilation, vasopressor use, maximum stage of acute kidney injury, and sequential organ failure assessment score, were included in the multivariate logistic regression. The model achieved AUCs of 0.864 and 0.808 in the MIMIC-IV and eICU-CRD databases, respectively. The calibration curve also confirmed the predictive ability of the model, while the decision curve confirmed its clinical value.

CONCLUSION

The nomogram has high accuracy in predicting in-hospital mortality. Improving the included predictors may help improve the prognosis of patients.
Aerospace Hydraulic and Pneumatic Specifications, Standards, Recommended Practices, and Information Reports
Authors:   A-6 Aerospace Actuation, Control and Fluid Power Systems
Published: April 2024

This SAE Aerospace Information Report (AIR) lists military and industry specifications, standards, recommended practices, and information reports applicable to aerospace hydraulic and pneumatic systems and components.
Rivets, Solid, UNS N04400, Corrosion Resistant 67Ni - 31Cu Procurement Specification for
Authors:   E-25 General Standards for Aerospace and Propulsion Systems
Published: April 2024

This procurement specification covers aircraft-quality solid rivets made from a corrosion resistant nickel-copper alloy of the type identified under the Unified Numbering System as UNS N04400 and of 46 ksi minimum shear strength.
Characterization of tumors of jaw: Additive value of contrast enhancement and dual-energy computed tomography
Authors: Viswanathan Deepak Justine , Bhalla Ashu Seith , Manchanda Smita , Roychoudhury Ajoy , Mishra Deepika , Mridha Asit Ranjan
Published: April 2024

BACKGROUND

Currently, the differentiation of jaw tumors is mainly based on the lesion’s morphology rather than the enhancement characteristics, which are important in the differentiation of neoplasms across the body. There is a paucity of literature on the enhancement characteristics of jaw tumors. This is mainly because, even though computed tomography (CT) is used to evaluate these lesions, they are often imaged without intravenous contrast. This study hypothesised that the enhancement characteristics of the solid component of jaw tumors can aid in the differentiation of these lesions in addition to their morphology by dual-energy CT, therefore improving the ability to differentiate between various pathologies.

AIM

To evaluate the role of contrast enhancement and dual-energy quantitative parameters in CT in the differentiation of jaw tumors

METHODS

Fifty-seven patients with jaw tumors underwent contrast-enhanced dual-energy CT. Morphological analysis of the tumor, including the enhancing solid component, was done, followed by quantitative analysis of iodine concentration (IC), water concentration (WC), HU, and normalized IC. The study population was divided into four subgroups based on histopathological analysis-central giant cell granuloma (CGCG), ameloblastoma, odontogenic keratocyst (OKC), and other jaw tumors. A one-way ANOVA test for parametric variables and the Kruskal-Wallis test for non-parametric variables were used. If significant differences were found, a series of independent t -tests or Mann-Whitney U tests were used.

RESULTS

Ameloblastoma was the most common pathology (n = 20), followed by CGCG (n = 11) and OKC. CGCG showed a higher mean concentration of all quantitative parameters than ameloblastomas (P < 0.05). An IC threshold of 31.35 × 100 μg/cm3 had the maximum sensitivity (81.8%) and specificity (65%). Between ameloblastomas and OKC, the former showed a higher mean concentration of all quantitative parameters (P < 0.001), however when comparing unilocular ameloblastomas with OKCs, the latter showed significantly higher WC. Also, ameloblastoma had a higher IC and lower WC compared to “other jaw tumors” group.

CONCLUSION

Enhancement characteristics of solid components combined with dual-energy parameters offer a more precise way to differentiate between jaw tumors.
Strategies for Sustainable Management of Mineral Resources for Koreaʼs Major Battery Producers (LG Energy Solution, Samsung SDI, SK On)
Authors: Kwon Seongku , Han Suho , Park Junhee , Cho Yoora , Rhee Jay Hyuk , Ok Yong Sik
Published: April 2024

The proliferation of global regulations concerning sustainability and environmental protection poses a significant challenge to maintaining corporate sustainability. Consequently, companies must strategically respond to navigate these regulations in their management plans. The objective of this research was to analyze how Korean companies(LG Energy Solution, Samsung SDI, SK On) are responding to sustainable mining and procurement and how they adopt environmentally friendly practices in their mineral supply chain for battery manufacturing. We also proposed new actions to enhance their management strategies for sustainable mineral resource management. Our observations indicated that companies should implement a long-term performance measurement throughout their mineral supply chain. Additionally, there is an urgent need to develop a more proactive environmental management plan when evaluating suppliers from mineral extraction to utilization, adhering to global guidelines such as OECD regulation. In addition to the widely adopted monitoring of greenhouse gas emissions, priority assessments must be undertaken concerning soil and water pollution, waste management, and biodiversity loss within the supply chain linked with climate change under the nature-positive concept. We recommended the establishment of a recycling system for battery waste(i.e., minerals), which is essential for a resilient battery supply chain.
Dictionnaire des régionalismes médiévaux : la Galloromania nord-orientale (DRM)
Authors: Carles Hélène , Glessgen Martin , Robecchi Marco , Bossone Alessandra
Published: April 2024

Le Dictionnaire des régionalismes médiévaux (DRM) consacré à la Galloromania nord-orientale a été conçu suite aux résultats du volume sur la régionalité lexicale (Glessgen/Trotter 2016) et à partir de la méthodologie du Trésor galloroman des origines (Carles 2017). Il appréhende la régionalité lexicale au Moyen Âge sur une base empirique élargie à partir du vocabulaire des séries oïliques orientales et francoprovençales des Documents linguistiques galloromans (DocLing) et en faisant appel à de très nombreuses sources complémentaires appartenant aux genres textuels divers. Les DocLing, quant à eux, offrent une matière fiable permettant une exploitation dans les meilleures conditions philologiques et informatiques puisque les actes sont originaux, datés et généralement localisés avec une grande précision. Le DRM entend constituer, à travers l’étude systématique des régionalismes identifiés, un modèle méthodologique afin de mieux cerner la dimension diatopique du vocabulaire médiéval et de poser ainsi les fondements d’une ‘scriptologie lexicale’. Les 380 articles lexicologiques individuels, qui forment la partie principale de l’ouvrage, placent l’usage des mots dans leurs contextes, font l’inventaire de leur traitement dans la lexicographie de référence, établissent leur étymologie et proposent un commentaire interprétatif de leur trajectoire. La première partie du DRM présente la méthodologie suivie, répertorie de manière exhaustive les sources exploitées et met en relief les résultats les plus significatifs en prenant appui sur la partie lexicographique.
Raconter la Grande Guerre comme « une banale histoire humaine » ? Quatre tentatives littéraires de gérer la mémoire de la Première Guerre mondiale
Authors: Jud Andrea
Published: April 2024

L’intérêt médiatique suscité par le centenaire de la guerre de 1914-18 peut expliquer, du moins en partie, la récente reprise du sujet dans le domaine littéraire. La présente étude essaie de montrer que l’attention particulière portée à ces romans est également à chercher dans leur nouvelle approche, laquelle implique une réflexion sur la (re)construction de la mémoire ainsi que sur les possibilités et les limites de sa transmission. À travers l’analyse des quatre romans Cris de Laurent Gaudé, Les Âmes grises de Philippe Claudel, Au revoir là-haut de Pierre Lemaître et L’Odeur de la forêt d’Hélène Gestern, cette étude vise à montrer que ces « récits qui évoquent la guerre » (Viart) réfléchissent, par leur structure et leur manière de raconter spécifiques, aux modes et aux conditions de la narration elle-même. Ils interrogent de manière critique leur capacité – et les limites de celle-ci – à accéder à ce passé et à le relater à notre époque. Cette (re)construction du passé, dont l’ambition est de venir enrichir le processus menant à sa maîtrise, peut être comparée à un ‘travail d’intégration’, celui-ci contribuant finalement à aider l’individu et la collectivité à trouver la paix.
МОНІТОРИНГ ІННОВАЦІЙНОГО РОЗВИТКУ ПІДПРИЄМСТВ ЖИТТЄЗАБЕЗПЕЧЕННЯ МІСТ
Authors: Хайло Яна Миколаївна , Хайло Владислав Олександрович
Published: April 2024

В книзі розглянуті питання розробки і впровадження моніторингового комплексу контролю та координації індикативних показників стану і розвитку підприємств життєзабезпечення міста. Методи інформаційно-аналітичного дослідження зміни ресурсного потенціалу підприємства адаптовані до галузевої специфіки і мають оригінальні підходи, а деякі, що пов’язані з визначенням виробничих і комерційних втрат, запропоновані в перше. Викладений матеріал буде корисним при організації централізованої аналітичної служби і впровадженні контролінгу в систему управління підприємств.
Escrevivências filosóficas com as cabaças ancestrais Conceição Evaristo e Paulina Chiziane
Authors: Freire Machado Adilbênia
Published: April 2024

Esse ensaio tem o intuito de dialogar com perspectivas filosóficas presentes no pensamento literário das cabaças ancestrais, posto serem mais velhas que abrem e semeiam caminhos para pessoas mais novas sempre em uma relação ancestral e encantada com nossos saberes e fazeres afrorreferenciados, a mineira Conceição Evaristo e a moçambicana Paulina Chiziane. Assim, faremos um passeio pelo atlântico, dialogando com vozes-mulheres de África e de sua Diáspora. Nesse sentido, as escrevivências literárias filosóficas dessas filósofas da sagacidade serão guia para movimentos de pertencimento e de enraizamento, posto as mulheres serem como o centro da terra, e é no centro da terra que se encontra a vida. Portanto, teceremos movimentos ancestrais e encantados bordados por saberes ancestrais femininos.
DANÇAR NAS DOBRAS
Authors: Souza Gomes Brenda K. , Herron More Anna
Published: April 2024

Apresento neste ensaio algumas considerações em torno do modo como o poeta mineiro Edimilson de Almeida Pereira articula o corpo, o pertencimento e a língua, em seu livro Homeless (2010), de modo que se veja nessa tríade e noutras brechas uma experiência radical do sujeito com a linguagem. Esses três aspectos rascunham nessa publicação o que chamo aqui de “lugar em trânsito”, um espaço plástico em que dançam o horror e a potência presentes na experiência de travessia diaspórica. O corpo do “sem lar” redesenha não só uma dinâmica de mundo, mas anuncia, mesmo na impossibilidade, uma língua porvir. No movimento de leitura que proponho aqui, me acompanham – além do poeta – os filósofos: Mbembe (2018); Deleuze (2011); Derrida (1996; 2009) e Gilroy (2012).
LITERATURA E O CAMPO DO POSSÍVEL
Authors: Ribeiro Guimarães Vinci Christian Fernando
Published: April 2024

Esse ensaio procurará pensar a importância atribuída por Gilles Deleuze às experimentações literárias, compreendendo-as como um espaço de abertura para outras possibilidades de pensar e de viver. Nesse sentido, ao reivindicar a necessidade da filosofia de se aproximar dessas experimentações de cunho literário, a fim de escapar de certo marasmo criativo que a dominava e abrir um novo campo de pensamento, Deleuze se insere em uma tradição francesa de filosofia cuja influência sobre seus contemporâneos não pode ser desprezada. Para além de marcar essa filiação, procuraremos pensar a importância concedida à literatura no interior do corpus deleuziano, bem como salientar as implicações políticas de seu uso pelo autor de Diferença e Repetição.
À PROCURA DO CORAÇÃO SELVAGEM E SECRETO:
Authors: Veloso Rodrigo Felipe
Published: April 2024

Trata-se de um estudo da obra O lustre, de Clarice Lispector, em diálogo com a antropologia (ritos de passagem) e da filosofia nietzscheana de vontade de potência. Pretendemos analisar como as personagens em seu processo de individuação, ou seja, de autoconhecimento se constituem enquanto indivíduos inseridos numa sociedade, em especial a protagonista Virgínia, que tem sua história apresentada desde a infância à maturidade. Por fim, pretendemos demonstrar como a passagem dos ritos na vida de Virginia, além de estar relacionada com os seus atos sociais e o seu desenvolvimento natural, está ligada, principalmente, ao modo como o texto é construído. Para tanto, utilizaremos autores como Arnold Van Gennep (2011), Mircea Eliade (1992), Friedrich Nietzsche (1985; 2002), dentre outros.
ISOLATION AND CHARACTERIZATION OF CYCLOEUCALENOL TRANSFERULATE FROM LEAVES OF Euphorbia tithymaloides
Authors: Anyam J. V. , Suleiman U. , Tor-Anyiin T. A. , Igoli J. O.
Published: April 2024

The latex, leaves, stems, and roots of Euphorbia tithymaloides (Euphorbiaceae) have traditionally been used to treat earaches, insect stings, ringworm, toothaches, skin cancer, umbilical hernia, and warts. Approximately 1 kg of the pulverized leaves was macerated successively with hexane and ethyl acetate, and resultant Crude extracts were phytochemically screened using standard established procedures. Ethyl acetate extract was loaded onto a column containing slurry of silica gel. Gradients of hexane in ethyl acetate mobile phase were used to elute the column, affording a total of 130 fractions. Fractions 41-47 gave tiny deposit on evaporation labelled UMPT (m.p: 269-270 oC).Their thin layer chromatography gave a single spot of Rf 0.61.These were combined and labelled UMPT44. Phytochemical screening of UMPT44 gave positive test for phenols and triterpenoids. Antimicrobial screening of UMPT44 showed that it was active against some fungi and bacteria. The zone of inhibition measured 30 mm when tested against Coniophora puteana, 29 mm against methicillin-resistant Staphylococcus aureus, 27 mm against Salmonella typhi, and 26 mm against Staphylococcus aureus, Fusarium oxysporum, and Escherichia coli. Additionally, there was a 25 mm zone of inhibition against Serpula lacrymans. The determination of minimum inhibitory concentration and minimum bactericidal/fungicidal concentration indicated that UMPT44 holds promise as a potential antimicrobial agent. Based on evaluation of NMR spectral data and comparison with literature reports, UMPT44 was identified as cycloeucalenol transferulate. This is the first time this compound is isolated from the plant
SYNTHESIS AND CHARACTERIZATION OF CHITOSAN FROM WASTE SHELLS OF Tagelus Plebeiu OBTAINED FROM OYOROKOTOR, RIVERS STATE, NIGERIA
Authors: Nordee B. S. , Ideriah T. K. J. , Obunwo C. C. , Cookey G. A.
Published: April 2024

The investigation was carried out to synthesize chitosan using waste shell of Tagelus plebeiu collected from Oyorokotor as an alternative to other kinds of shells. Standard procedures such as demineralization, deproteinization and deacetylation were used. Methods such as fourier transformed infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and scanning electron microscope (SEM) were used for characterization to obtain results. Results reveals FTIR spectra bands at 3637.9 cm-1 for hydroxyl and 3384.4 cm-1 for amino functional group as well as 18.20 at 2 titha from XRD pattern. The degree of deacetylation was recorded as 80.48 %, moisture content as 0.101 %, yield was 53.24 % and ash content was recorded as 25 %. It is therefore concluded that the waste shell of Tagelus plebeiu can be used in producing quality chitosan as an alternative to other kinds of shells.
Determinación de nitritos por espectrofotometría UV visible en productos embutidos de tipo jamón
Authors: García Yanina Nikolle Baca , Fuentes Jhunior Abrahan Marcía , Aguilera Héctor David Montoya , Toro Vilma Paola Chavez , Fernández Sergio , Baca José , Torres Mauricio , Gutierrez Yaleny , Padilla Rodimiro , Ore Franklin
Published: April 2024

El objetivo de esta investigación consistió en cuantificar mediante Espectrofotometría UV-Visible, el contenido de nitritos en productos embutidos de tipo jamón, distribuidos en la zona central de Honduras, para generar una alerta en cuanto a su consumo. Para su alcance, se empleó instrumentos descriptivos tipo encuesta para valorar el nivel de preferencia y la técnica de espectrofotometría a una longitud de onda de 540 nm para evaluar el contenido de nitritos en tres diferentes tratamientos. Los resultados sugieren que los productos embutidos de mayor aceptación por el consumidor son los de tipo jamón, principalmente aquellos que se elaboran a partir de carne de pollo. De igual manera esta investigación genera una alerta sobre la salud del consumidor, en vista que dos terceras partes de las marcas comerciales empleadas para esta investigación, no cumplen con la normativa de uso de aditivos, según lo establecido por el Codex Alimentarius.
Pengetahuan Masyarakat Tentang Tanda Bahaya Kehamilan Dengan Memberdayakan Masyarakat Dalam Mendeteksi Secara Dini di Kelurahan Ladang Bambu Kecamatan Medan Tuntungan
Authors: Manurung Nurdiana , Fitri Sari Rahma
Published: April 2024

Maternal mortality can occur during pregnancy, childbirth or postpartum. Maternal deaths in Indonesia are caused by 3 late and 4 too. One of the late factors is the delay at the family level in recognizing danger signs in pregnancy, childbirth and postpartum. Early detection of risk factors is necessary to reduce maternal and fetal mortality and morbidity. This is where the role of health workers in early detection of danger signs. This study aims to improve the ability of health cadres in early detection and referral of high-risk pregnancy, labor and postpartum cases. The research method used analytic research. Early detection of pregnancy danger signs by families and recognizing risk factors and complications, as well as appropriate treatment by health workers is the best way to reduce MMR and IMR. The targets of this activity were health cadres and pregnant women, 35 respondents were obtained in Kelurahan Baru Ladang Bambu, Medan Tuntungan Subdistrict. The interventions carried out in this activity were counseling, discussion, and simulation. The measuring instrument used pretest and posttest questionnaires. Data were analyzed using Wilcoxon test analysis. The results of the activity are an increase in the knowledge of cadres and pregnant women about the detection of danger signs of pregnancy, antenatal services provided can obtain data on the condition of their pregnancy and become information for pregnant women until now is still high.
Pemberdayaan Masyarakat Melalui Penyuluhan Perilaku Hidup Sehat Dan Bersih (Phbs) Pada Anak-Anak Untuk Meningkatkan Derajat Kesehatan di SD Swasta Bharlind Tahun 2023
Authors: Fitri Sari Rahma , Tampubolon Emelia Apriani
Published: April 2024

Clean and Healthy Living Behavior (PHBS) is all health behaviors that are carried out on awareness. There are many PHBS, hundreds of them.  For example about nutrition: eating a variety of foods, taking blood supplement tablets, consuming iodized salt, giving babies and toddlers vitamin capsules. Primary school-age children are also very vulnerable to health problems due to an unhealthy diet. Food sold at school or in the school environment does not all meet health and safety standards, and school children tend to prefer unhealthy foods either because of inadequate knowledge or because they are easily influenced by advertisements The subjects in the service activities are elementary school children at Bharlind Elementary School. The delivery of counseling material using the lecture method, the implementation of the service which is assisted by the teacher and followed by a question and answer session This community service activity aims to improve the level of health at Bharlind Private Elementary School in 2023 "was carried out on Wednesday, July 12, 2023 at 09.00 WIB until completion. When the activity began, elementary school students in grade 4SD were gathered in the classroom, then socialized counseling material about healthy and clean behavior (PHBS) in children, and conducted questions and answers to children. In the delivery of the material, it turned out that many children did not understand about healthy and clean living behavior (PHBS).   The application of PHBS can not only be applied in the home environment, but PHBS can also be applied in the school environment, namely by efforts to provide learning experiences or create a condition for individuals, provide information and conduct education to improve knowledge, attitudes and behavior through approaches to children.
Internal Factors Affecting Firm Value (Case Study of Manufacturing Companies in Indonesia)
Authors:   Department Of Management Faculty Of Economic and Business Universitas Airlangga, Malik Atiqa , Ismiyanti Fitri ,   Department Of Management Faculty Of Economic and Business Universitas Airlangga
Published: April 2024

Despite the pivotal role of the manufacturing sector in the Indonesian economy and its continuous growth, there exists a dearth of comprehensive research on the determinants of firm value within this sector. The lack of understanding regarding how financial factors such as leverage, liquidity, profitability, and firm size impact firm value among manufacturing companies listed on the IDX hinders effective decision-making for investors, creditors, stakeholders, and company management. This study aims to Investigate the effects of firm size, profitability, liquidity, and leverage on firm value is the main purpose of this study, which focuses on manufacturing companies listed on the Indonesia Stock Exchange (IDX). The population comprises manufacturing companies listed on the Indonesia Stock Exchange from 2018 to 2022. Using purposive sampling technique and going through the sampling criteria, a final sample of 82 companies was used in this research. The data analysis method used in this study was a regression analysis using SPSS software. The study revealed that higher debt levels (Leverage) and excessive cash reserves (Liquidity) were linked to decreased firm value. Additionally, the finding also shows that as companies became more profitable, their overall value tended to decrease. On a positive note, larger firms (Firm Size) exhibited higher company value. The findings have implications for investors, creditors, and stakeholders navigating the Indonesian manufacturing sector, providing nuanced insights into financial determinants of firm value. These findings emphasize the importance of a balanced financial strategy for companies and highlight the advantages of size in the economic landscape.
Psoriasis. Definition and Classification of A Complex Entity
Authors:   ISSSTE Dr Santiago Ramón y Cajal, Carrillo Daniela Guerrero
Published: April 2024

Psoriasis, a chronic inflammatory skin condition influenced by hereditary factors and immune system response, exhibits diverse clinical manifestations. While its global incidence is around 2%, prevalence varies across geographical regions and ethnicities. The most common form, psoriasis vulgaris, presents as red, itchy patches with silver-colored scales, predominantly affecting the trunk, limbs, and scalp. Other clinical subtypes include inverse psoriasis, guttate psoriasis, pustular psoriasis, and erythrodermic psoriasis, each with distinct features and impacts. Beyond skin manifestations, psoriasis is associated with various co-occurring medical conditions, including hyperlipidemia, hypertension, coronary artery disease, type 2 diabetes, and obesity. Psoriasis patients have an increased risk of cardiovascular disease, with severity correlating with the incidence of diabetes and cardiovascular events. Additionally, psoriatic arthritis affects around 40% of patients and is often accompanied by nail involvement. Recent studies utilizing imaging techniques like 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) and nuclear magnetic resonance spectroscopy have shed light on systemic inflammation and cardiovascular risk in psoriasis patients. Treatments targeting IL-23 and IL-17 have shown promising results, though long-term efficacy and drug survival remain areas of concern. Psoriasis profoundly impacts patients' quality of life, with psychological distress comparable to cancer and depression. However, treatment can significantly alleviate symptoms and improve overall well-being. Ongoing research aims to expand treatment options, particularly targeting novel molecular pathways. In conclusion, while significant progress has been made in understanding and treating psoriasis, challenges remain in optimizing therapy selection and long-term management. Further research is warranted to elucidate the complex genetic and immunological underpinnings of the disease and to enhance treatment outcomes for affected individuals
Teknik Pengambilan Gambar (Angle) Dalam Memberikan Makna Dan Emosi Yang Disampaikan Pada Film Pendek Sabda Rindu
Authors: Akbar Farhan Aidil , . Defhany
Published: April 2024

In filmmaking, shooting techniques have a very important role in providing the meaning that you want to convey to the audience. Therefore, when making a film, it is necessary to take into account the size of the images when taking them so that the visuals displayed can please the audience's eyes and provide a message that is easy to understand. The cameraman is tasked with compiling, editing and reviewing images and is responsible for the production process from start to finish, then handed over to the editor. The cameraman himself carries out tasks starting from preparing the camera settings, checking the audio and adjusting the shooting angle because all the images and audio taken must be complete so as not to make it difficult for the editor to edit. The film Sabda Miss is a slice of life genre film where in this film, the cameraman tries to emphasize and emote the actors with the aim of bringing the audience to feel the emotions conveyed by the actors. In the production of the film Sabda Miss, the cameraman helps the director in visualizing the film script that has been provided by the script writer. There are several shooting techniques, one of which is close up. A close up shot itself is a shot from the top of the head to the neck, in one scene of the film Sabda Miss there are several techniques for taking close up shots. The cameraman tries to give an emotional impression of the actor so that the audience can be carried away by the actor's emotions. Therefore, the shooting techniques used in the film Sabda Missing are able to provide an attractive and professional film quality.
Aktivitas Promosi Wisata Kuliner Ikan Bilih Sebagai Makanan Khas Danau Singkarak Kabupaten Tanah Datar
Authors: Faizah Salsabila , Edlina Ria
Published: April 2024

The problem studied in this research is culinary tourism promotion activities for bilih fish as a typical food of Lake Singkarak in promoting and marketing bilih fish culinary tourism. Based on these problems, this research aims to describe the marketing promotion activities used by UMKMactors at the Tourism Department in carrying out promotional activities for the Ikan Bilih culinary tourism product.
The research approach used is descriptive qualitative. The source of research data is the result of observations of the activities of the Tanah Datar Regency Tourism Office and UMKM actors at Lake Singkarak. Data collection was carried out using observation, interviews and documentation techniques.
The theory used is IMC (integrated marketing communications). This theory was put forward to show that the Bilih Fish culinary tourism promotional activities used by Bilih Fish traders in marketing their tourism products are advertising techniques, sales promotions, personal sales "face to face sales", public relations "public relations"
Based on the presentation of results based on data and also the results of interviews conducted by researchers, it was concluded that promotional activities for culinary tourism of bilih fish as a typical food of Lake Singkarak, Tanah Datar Regency, it could be concluded that the five promotional communication indicators implemented by UMKM in Lake Singkarak were based on promotion theory. The mix is ​​advertising (public relations), direct marketing (direct marketing), sales (sales promotion), and personal sales (personal sales) fifth in terms of promotions carried out to increase sales of Bilih Fish in Lake Singkarak. Of the fifth indicators, the least dominant among UMKM actors is advertising, in other words there is still a lack of innovation and creativity in promoting it, not all Ikan Bilih MSME actors in Lake Singkarak are able to market Ikan Bilih culinary delights as creatively as possible. The lack of unity between UMKM in terms of pricing also has an impact on sales of Bilih Fish. The role of the Creative Economy Tourism Office is to provide guidance, facilities and financial support to UMKM.
Teknis Komunikasi Dalam Peluang Usaha Photography Di Prince Studio Photography Padang
Authors: Shadikyanto Fadjri , . Defhany
Published: April 2024

This final assignment of scientific paper writing is conducted to understand the communication efforts that can be observed in a professional interaction. In this case, the author focuses observations with the title "Observation of Technical Communication in Photography Business Opportunities at Prince studio photography Padang". It is a final study of scientific work aimed at exploring and analyzing the communication interactions that occur within the photography business environment, specifically at Prince studio photography Padang. In this context, the AIDDA theory (Attention, Interest, Desire, Decision, Action) is used as a framework to understand the communication process that occurs between the photography studio and its potential customers. This scientific paper uses a structured participant observation method to collect data. The results of the scientific paper show that in efforts to build relationships with customers, the photography studio uses the AIDDA theory as a communication technique, starting from attracting attention, generating interest, creating desire, encouraging decision-making, to prompting purchase actions. Additionally, it was also found that aspects such as visual impression, personal interaction, and marketing strategies play a significant role in influencing the effectiveness of communication in the context of photography business.
Türk Veritabanı “TRDİZİN”de Taranan Endodonti Araştırmalarının Bibliyometrik Analizi
Authors: ÖZDEMİR OLCAY
Published: April 2024

Amaç: Bibliyometrik analizler; basılmış makalelerin, yazarların, dergilerin, yayın sahibi kurumların araştırılmasında ve ülkelerin bilimsel etkinliğinin ortaya konmasında önemli bir analiz tipidir. ULAKBİM bünyesinde bibliyometrik araştırmalar yürütülmekle beraber, endodonti alanı ile ilgili TRDİZİN indeks değerlendirmesi şu ana kadar bildirilmemiştir. Bu çalışmanın amacı Türk veritabanı “TRDİZİN”de taranan endodonti alanında çalışma trendlerinin belirlenerek verilerin sayısal analizini sunmaktır. Gereç ve Yöntem: “Endodonti” ve “kök kanal tedavisi” anahtar kelimeleri Türkçe ve İngilizce olarak aratılarak TRDİZİN veritabanında ulaşılan endodonti alanını direk ilgilendiren bütün yayınlar analiz edildi. Editöre mektup ve endodonti ile direk olarak bağlantısı bulunmayan yayınlar çalışma dışı bırakıldı. Yayınların başlığı, ilk yazar, kurum, şehir, ülke, yazar sayısı, dergi, atıf sayısı, çalışma tipi ve kaydedildi. Bulgular: Toplamda ulaşılan 1995-2021(Mart) yıllarını kapsayan 1077 yayından dublikasyonlar ve alan dışı çalışmalar çıkarılmıştır. Dahil edilen yayınlar en fazla Türkçe olmak üzere üç dilde yapılmıştır. En fazla yayın gönderen ülke olan Türkiye’yi Kuzey Kıbrıs Türk Cumhuriyeti takip etmektedir. Ankara ili en çok yayına sahipken İstanbul ikinci sırada yer almaktadır. Diğer yıllara göre karşılaştırıldığında en fazla yayın 2018 yılında yapılmıştır. Çalışmaların büyük çoğunluğu özgün araştırma makalesi olmakla beraber sadece ulusal veritabanında taranan yayınların uluslararası veritabanında da taranan makalelere göre atıf oranlarının düşük olduğu gözlenmiştir. Sonuç: Bu analiz, Türkiye'de endodonti alanında artan araştırma eğilimini ortaya koymaktadır. Bununla birlikte, Türk veritabanında dizinlenen makalelerin ulusal ve uluslararası etkisinin yükseltilmesi ihtiyacını vurgulamaktadır.
Evaluation of Knowledge Levels of Undergraduate and Postgraduate Dentists Concerning Anatomical Landmarks on Panoramic Radiography
Authors: TOKGÖZ KAPLAN TAİBE , YILDIZ YASEMİN
Published: April 2024

Objective: This study aimed to evaluate the knowledge level of dental students and newly graduated dentists concerning anatomical landmarks identified on panoramic radiographs. Methods: This study was conducted as a web-based survey. Students continuing their education in the 4th and 5th grades of dentistry faculties and dentists who graduated within the last one year were included in our study. The answers given to the anatomical points on the panoramic radiograph were recorded as "true" and "false". SPSS was used to analyse the data. The data obtained were analysed by Kolmogorov-Smirnov test and Mann-Whitney U Test. p<0.05 was considered statistically significant. Results: 300 people participated of which 59.6% of the participants were female and 40.4% were male. The answers given to a total of 18 anatomical point questions did not show a significant difference according to gender (p=0.469). There was no question that all participants answered correctly. The highest correct answer rate was found for the anatomical point 'Mental foramen' with 289 (96.3%) participants. The lowest correct answer rate was found for the anatomical point 'Soft palate' with 48 (16%) participants. According to educational status, 5th grade students were the group with statistically significantly lower correct answers (p=0.017) Conclusions: These results indicate that training approaches should be developed for anatomical landmarks with lower correct response rates. Dentists working on a complicated structure should have a good command of this anatomy, and for this purpose, efforts should be made during the teaching program on anatomical structures that are difficult to identify and keep their knowledge up to date.