bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN USIA, MASA KERJA, WAKTU KERJA, SIKAP KERJA DAN AKTIVITAS PEKERJAAN DENGAN KEJADIAN NYERI PUNGGUNG BAWAH PADA PETANI PADI DESA SEMEN
Authors: Nurcahyani Ari Dwi , Ekawati Ekawati , Jayanti Siswi
Published: May 2024

Indonesia is an agrarian country so that agriculture is one of the sectors with the largest number of workers. Agriculture is an informal sector job that still uses a lot of manual handling methods so that it has the potential to cause complaints of low back pain. Low back pain is a health problem in the form of acute pain that is felt in the lower back (lumbosacral) area in the form of local or radicular pain. Risk factors for low back pain include individual factors, occupational factors and environmental factors. This research is a quantitative-research with analytic observational method and cross-sectional approach. The population is farmers from of Semen village and registered on rukun tani group. The sample is 30 people using total sampling. Independent variables is age, working period, working time, work attitudes and work activities with dependent variable Low Back Pain. Data collection techniques used individual characteristic questionnaires, nordic body map, VAS scale and OWAS method. Data analysis technique uses Fisher’s Exact Test statistical test. The results showed a greater distribution of independent variables age > 35 years, work experience > 5 years, work attitudes requiring improvement, and heavy work activities. The results of the bivariate analysis showed that there was a significant relationship between age (p-value = 0.035), working period (p-value = 0.002) and working time (p-value = 0.004) with complaints of low back pain in rice farmers in hamlet X Semen Village as evidenced by p-value <0.05. Keywords: Low Back Pain, Rice Farmes, VAS scale, OWAS method.
Preliminary investigation into the genetic etiology of short stature in children through whole exon sequencing of the core family
Authors: He Jinshui , Zhang Shuyun , Kang Yueya , Zhang Yugui , Zheng Zhugui , Ruan Minyi
Published: May 2024

A comprehensive survey was carried out to investigate the genetic etiology of short stature in children by whole exon sequencing of a core family cohort to find and study mutations in multiple genes to assess their potential correlations to low height in children. The study included 56 pediatric patients from the Department of Pediatrics at the Zhangzhou Affiliated Hospital of Fujian Medical University. The participants met strict inclusion criteria, including age, Han Chinese ethnicity, low height standard deviation score, and the absence of known causes for short stature. Core pedigrees were identified using exome sequencing. After sequencing, variations were categorized and interpreted according to a variety of factors, including inheritance, location, type, and disease-causing gene databases. Variants were verified by Sanger sequencing. Most of the 97 gene mutations were missense. ACAN, PHEX, and COL2A1 were the most common gene mutations. Copy number variations were identified, particularly associated with the PHEX gene. Protein functional studies revealed that the mutations had a considerable influence on disease-promoting damage. The chromosomal locations with the highest enrichment of these genes were chr12, chr5, and chr2. In conclusion, the study revealed numerous genetic changes that may substantially impact physiological processes and disease. These findings establish the basis for further investigations into their diagnostic and therapeutic capabilities.
Japanese EFL undergraduate students’ use of the epistemic modal verbs may, might, and could in academic writing
Authors: Hollmann Willem B. , Fujimoto Kazuko , Kuroda Masahiro
Published: May 2024

Modifying and hedging one’s claims appropriately is an important characteristic of academic writing. This study focuses on the three main English modal verbs used to express “epistemic possibility” to avoid making strong statements, viz., may, might, and could. The purpose of this corpus-based study is to explore modal verb usage by Japanese EFL undergraduate students and consider pedagogical implications of our findings. Our analysis suggests that the Japanese students’ use of these modal verbs, especially could, has a tendency to be informal and insufficiently academic. While the Japanese students use could very frequently, they do not use it sufficiently in the sense of “epistemic possibility”, and some of their use is inappropriate not just in academic English but in English more generally. The observed high frequency of could may be related to topics and may also be due to the influence of L1. We discuss different factors that may explain the findings, based mainly on the overview of factors impacting on EFL learners’ use of academic English offered by Gilquin and Paquot (2008). Too chatty: Learner academic writing and register variation. English Text Construction 1(1). 41–61), suggest several additions to this overview, and discuss implications for the instruction of these modal verbs in academic writing and in order to improve relevant teaching materials.
Das Nacaps-Datenportal – Potenziale, Besonderheiten und Datenqualität in interaktiven digitalen Reportings
Authors: Azeroual Otmane
Published: May 2024

Die Veröffentlichung von Forschungsaktivitäten und -ergebnissen sowie die verschiedenen Beteiligten stellen den Datenaustausch, die Exploration und die Visualisierung vor große Herausforderungen. Für die vom Bundesministerium für Bildung und Forschung (BMBF) geförderte National Academics Panel Study (Nacaps) hat das Deutsche Zentrum für Hochschul- und Wissenschaftsforschung (DZHW) ein offenes Datenportal entwickelt. Mit interaktiven Grafiken zu Themen wie Promotionsbedingungen, Karriereabsichten, Mobilität oder Finanzierung bietet das Portal einen Überblick zur Lebens- und Arbeitsrealität Promovierender in Deutschland. Befragungsdaten werden im Datenportal so aufbereitet, dass sie niedrigschwellig verwendbar sind. Da die Daten in offenen und wiederverwendbaren Formaten ohne Einschränkung unentgeltlich zur Verfügung gestellt werden, können sie gleichermaßen von der Forschung und der Öffentlichkeit genutzt werden. Zugleich bietet das Portal kooperierenden Partnerhochschulen in einem geschützten Raum eine hochschulspezifische Berichterstattung über die Daten von Promovierenden ihrer Einrichtung. Erörtert werden die mögliche Weiterentwicklung und effektiven Nutzung des Nacaps-Datenportals für das Management von offenen Befragungsdaten. Dabei werden besonders die Qualität offener Befragungsdaten sowie das Potenzial und die Besonderheiten des Nacaps-Datenportals bei der Visualisierung von Befragungsdaten diskutiert.
On the construction of various soliton solutions of two space-time fractional nonlinear models
Authors: Tariq Kalim U. , Liu Jian-Guo
Published: May 2024

In this article, we investigate a couple of nonlinear fractional models of eminent interests subsequently the conformable derivative sense is used to designate the fractional order derivatives. The given structures are transformed into nonlinear ordinary differential equations of integer order, and the extended simple equation technique is then employed to solve the resulting equations. Initially, the nonlinear space time fractional Klein–Gordon equation is considered emerging from quantum and classical relativistic mechanics, which have application in plasma physics, dispersive wave phenomena, quantum field theory, and optical fibres. Later, the (2 + 1)-dimensional time fractional Zoomeron equation is analysed which is convenient to explore the innovative phenomena related to boomerons and trappons. As a result, various new soliton solutions are successfully established. The reported results offer a key implementation for analysing the soliton solutions of nonlinear fractional models which are extremely encouraging arising in the recent era of science and engineering. The 3D simulations have been carried out to demonstrate dynamics of the various soliton solutions for a given set of parameters.
Verified of leakage loss, birefringence, nonlinear parameters and total number of modes in silica/silica doped and plastic fibers for fiber system efficiency improvement
Authors: Prabu Ramachandran Thandaiah , Santhakumar Dhilipkumar , Kumar Ata Kishore , Lalitha Sangeetham Dharuman , Jebanazer Jeneetha , Mohan Salem Balamurugan , Ahmed Aisha abd Rahman
Published: May 2024

This paper has clarified verified of leakage loss, birefringence, nonlinear parameters and total number of modes in silica/silica doped and plastic fibers for fiber system efficiency improvement. The signal power loss is demonstrated with silica/silica doped/plastic fibers at various ambient temperatures. The estimated number of fiber modes is clarified in the core against silica/silica doped/plastic fiber core radius. The fiber birefringence is studied against silica/silica doped/plastic fiber core radius. The silica/silica doped/plastic fibers effective refractive index is clarified versus ambient temperature variations. The nonlinear parameter is demonstrated based silica doped fiber against the dopant concentration ratio with different temperature variations. The effective area cross section is studied based silica doped fiber against the dopant concentration ratio with different temperature variations. The predicted fiber loss is demonstrated against the fiber operating wavelength for silica glass fibers/silica doped fibers/plastic fibers. As well as the predicted fiber loss is clarified and studied versus fiber core radius for silica glass/silica doped/plastic fibers.
Biomedical and therapeutic potential of marine-derived Pseudomonas sp. strain AHG22 exopolysaccharide: A novel bioactive microbial metabolite
Authors: Aloraini Ghfren S. , Albureikan Mona Othman I. , Shahlol Aisha M. A. , Shamrani Taghreed , Daghistani Hussam , El-Nablaway Mohammad , Tharwat Nagwa A. , Elazzazy Ahmed M. , Basyony Ahmed F. , Ghareeb Ahmed
Published: May 2024

Microbial exopolysaccharides (EPSs) are gaining interest as alternatives to chemical antioxidants and pharmaceuticals. This study mines the promising biomedical and antimicrobial potential of a marine bacterium, a prolific EPS producer, isolated from the Red Sea. Pseudomonas sp. strain AHG22 generated an EPS weighing 6.98 g·L−1, coded EPSF8, subjected to FT-IR and HPLC chemical analysis. EPSF8 was then investigated for antioxidant assessment by 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, ABTS˙
+
, nitric oxide, total antioxidant capacity (TAC), and ferric reducing antioxidant power (FRAP). EPSF8 had an IC50 of 46.99 μg·mL−1 in the DPPH antioxidant assay and antioxidant capacities of 219.45 μg·mg−1 ascorbic acid equivalent (AAE) in the TAC assay and 54.15 μg·mg−1 AAE in the FRAP assay. The in vitro anti-inflammatory effect of EPSF8 was tested against 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymes and compared with the drugs ibuprofen and celecoxib used as controls. The IC50 values of 5-LOX, COX-2, ibuprofen, and celecoxib were found to be 14.82, 15.49, 1.5, and 0.28 μg·mL−1, respectively. Additionally, EPSF8 revealed antidiabetic activity toward α-amylase and α-glucosidase, and the IC50 values were 93.1 and 127.28 μg·mL−1, compared to those of acarbose (50.93 and 4.13 μg·mL−1, respectively). Anti-obesity activity of EPSF8 by lipase inhibition revealed IC50 = 56.12 μg·mL−1 compared to orlistat (IC50 = 20.08 μg·mL−1) as a control. EPSF8 displayed antibiofilm and bactericidal activity against Gram-positive (G +ve) and Gram-negative (G −ve) ATCC pathogenic bacterial strains. It had a minimum bactericidal concentration/minimum inhibitory concentration ratio ≤2, indicating a broad bactericidal spectrum. Furthermore, EPSF8 is evidenced to have a promising anti-butyrylcholinesterase activity for the control of Alzheimer’s disease. The findings of the present analysis suggest that the isolated Pseudomonas sp. strain AHG22 EPS can potentially be explored as a promising green therapeutic compound.
Physical activity with person-centered guidance supported by a digital platform or with telephone follow-up for persons with chronic widespread pain: Health economic considerations along a randomized controlled trial
Authors: Gyllensten Hanna , Larsson Anette , Bergenheim Anna , Barenfeld Emmelie , Mannerkorpi Kaisa
Published: May 2024

Objectives

The aim was to investigate the resource use and costs associated with the co-creation of a physical activity plan for persons with chronic widespread pain (CWP) followed by support through a digital platform, compared to telephone follow-up.

Methods

In this 12-month cost comparison study following up results after a randomized controlled trial, individuals with CWP, aged 20–65 years, were recruited at primary healthcare units in Western Sweden. All participants developed a person-centered health-enhancing physical activity plan together with a physiotherapist. Participants were then randomized to either an intervention group (n  =  69) who had a follow-up visit after 2 weeks and was thereafter supported through a digital platform, or an active control group (n  =  70) that was followed up through one phone call after a month. Costs to the health system were salary costs for the time recorded by physiotherapists when delivering the interventions.

Results

The reported time per person (2.8 h during the 12 months) corresponded to costs of SEK 958 (range: 746–1,517) for the initial visits and follow-up (both study groups), and an additional 2.5 h (corresponding to a mean SEK 833; range: 636–1,257) for the time spent in the digital platform to support the intervention group.

Conclusion

After co-creation of a physical activity plan, it was more costly to support persons through a digital platform, compared to telephone follow-up.
Glyceraldehyde derivatives inspired by empagliflozin as potential anti-heart failure agents independent of glucose-lowering effects
Authors: Li Xiao , Yao Yue , Zhou Luoyifan , Yang Jin , Chen Xin , Zhang Chao , Wang Manjiong , Li Jian , Li Baoli , Xu Yixiang
Published: May 2024

Sodium-glucose cotransporter 2 inhibitors are a class of glucose-lowering drugs known for robust cardiovascular protective properties. However, the side effects induced by Sodium-glucose cotransporter 2 inhibition limit application in cardiovascular medicine. Our prior research showed that thoughtful structural modifications can dissociate the anti-heart failure activity from glucose-lowering effects. Moreover, we showed that the glyceraldehyde derivative, JX22, developed by scaffold hopping from empagliflozin, exhibits a superior cardiomyocyte protective effect, albeit with increased cytotoxicity compared to empagliflozin. In the current study systematic structural modifications of JX22 were performed to enhance anti-heart failure efficacy and safety, while reducing glucose-lowering activity. Twenty glyceraldehyde-based derivatives were synthesized and compound 12 emerged as an optimal candidate by exhibiting an improved cytoprotective effect compared to JX22. Compound 12 significantly inhibited the activity of NHE1 on the myocardial membrane, thereby maintaining intracellular ion homeostasis. In vivo efficacy results demonstrated that compound 12 at 10 mg/kg significantly ameliorated cardiac dysfunction, myocardial fibrosis, and exercise tolerance in isoproterenol-induced heart failure mice without a glucose-lowering effect. Furthermore, compound 12 exhibited favorable safety profiles in single-dose toxicity and hERG inhibition tests, along with promising pharmacokinetic properties in mice. The current study not only underscores the potential of compound 12 for further investigation but also highlights the effectiveness of the scaffold hopping strategy.
See and treat hysteroscopy. Future challenges and new prospective
Authors: Sofoudis Chrisostomos , Fani Grozou , Orestis Tsonis , Minas Paschopoulos
Published: May 2024

Rapid development of technology, which has been achieved over the last decade, has helped decisively in the investigation and treatment planning of pathological conditions in the field of endoscopy and more specifically of hysteroscopic gynecological procedure. Through endless efforts in the wider medical field, hysteroscopic access of the endocervix and at the same time of the endometrial cavity was established both on a diagnostic and invasive level as an integral tool of gynecological surgery, revealing great sensitivity but also great specificity. Hysteroscopic intervention provides the possibility of direct visual imaging of endocervix and endometrial cavity and directly optically guided biopsies for histological confirmation. Globally, performance of hysteroscopy at the level of an outpatient clinic (office hysteroscopy) has a success rate of 98% and is considered a more valid method compared to diagnostic curettage. Design of increasingly flexible and smaller diameter endoscopic tools achieved the possibility of reviewing the endometrial cavity at the level of an outpatient office (office hysteroscopy), without analgesia. A study included cases of patients in whom both diagnostic and therapeutic approach were performed. Our study is focused on specific cases involving hysteroscopic procedures performed at the level of an outpatient clinic as part of an initial diagnostic examination and concurrently as part of an invasive treatment result. As culmination of all above was established hysteroscopic diagnosis and treatment in one session. (See and Treat Hysteroscopy). The aforementioned led to the development of hysteroscopic diagnosis and treatment in the context of See and Treat Hysteroscopy.
Use of Ethnoveterinary Medicinal Plants to Treat Cattle Diseases by the Oulad Heriz Farmers in the Chaouia Region, Northwest of Morocco
Authors: Chaachouay N. , Azeroual A. , Bencherki B. , Benkhnigue O. , Zidane L.
Published: May 2024

Using medicinal plants for healthcare practices in indigenous communities presents a chance to discover natural remedies. This study aims to provide a detailed account of the ethnoveterinary knowledge of medicinal plants utilized for therapeutic purposes. From December 2020 to December 2021, a field investigation was carried out within the Oulad Heriz tribes. Two hundred local farmers were interviewed using open-ended, semi-structured discussions, free listing and focus groups. A total of one hundred medicinal plants belonging to 87 genera and 33 families were discovered to be employed for ethnoveterinary purposes. Rosmarinus officinalis L. was the most frequently utilized ethnoveterinary plant species in the study area (70 citations). Leaves are shown to be the most commonly employed plant parts (55%). However, digestive disorders were the most often mentioned ailment (33 medicinal plants, 599 citations), and most herbal medicines were made by infusion (46.2%). According to the current investigation findings, local farmers in Oulad Heriz have continuous knowledge of ethnoveterinary plants. This ethnoveterinary medicinal heritage needs to be incorporated with contemporary medicine to use plants and their products as potentially viable medications for various cattle illnesses.
Data to the Malaysian Liverwort Flora, IV: a New Species of Mastigopelma Mitt. (Lepidoziaceae) from Cameron Highlands, Peninsular Malaysia
Authors: Lee G. E. , Pesiu E. , He X. L.
Published: May 2024

The new species, Mastigopelma latiffiana G. E. Lee, E. Pesiu et X. L. He, discovered in Pen-insular Malaysia, is described and illustrated as a new addition to the genus Mastigopelma Mitt., of the family Lepidoziaceae. The new species is corticolous, growing on a tree branch in a moist montane forest in Cameron Highlands, Pahang, at 1,900 m alt. It is characterised by the leafy shoots arising from stolons, branches, when present, all ventral-intercalary, and terminal branching lacking; asymmetrical leaves with almost straight ventral margins, rounded to truncate leaf apices, entire-margined leaves, thickened cell walls with nodular trigones, and glistening-homogeneous oil bodies (2–4 per cell); and retuse to blunt teethed underleaf apices. This discovery has increased the total number of known species of Mastigopelma Mitt. to five. An identification key to all the species of the genus is presented.
ChatGPT from the students' point of view – Lessons from a pilot study using ChatGPT in business higher education
Authors: Kétyi András , Géring Zsuzsanna , Dén-Nagy Ildikó
Published: May 2024

In a recent pilot study, we examined the potential benefits and opportunities that ChatGPT can bring to higher education, particularly from the perspective of business students and educators. The study included 41 participants and aimed to explore their opinions on using ChatGPT in business language classes. Twelve students did not use ChatGPT during the course (control group), while 29 students used it actively (experimental group). Examining their experiences and comparing the two groups, it is evident that students see the benefits and disadvantages of ChatGPT and use it for tasks they find helpful. However, the practice and hands-on experience helped the experimental group members gain much more diverse and nuanced opinions about ChatGPT. These results underline that universities and their boards must embrace the technology and find reasonable areas to use ChatGPT. These may not only be connected to assignment forms and plagiarism, but can embrace more general topics, like equal eligibility to these new technologies or strengthening the students' social and emotional intelligence and skills to help their future lives.
Knowledge, Attitude and Practice Related to Organ Donation Among Healthcare Workers at University of Kebangsaan Malaysia Medical Centre (UKMMC)
Authors: Wan Abdul Halim Wan Haslina , Mohd Din Norshamsiah , Kuppusamy Viknesh , Samsuri Sinaran , Mat Ropi Nurul Ayuni Syafiqah , Kanapathy Thivyasri , Mohd Shaiful Bahri Nur Najihah
Published: May 2024

Purpose: The demand for organ donation is progressively increasing in Malaysia. Healthcare personnel play a crucial role in educating potential donors. This study is aimed to determine the level of knowledge, attitude and practice (KAP) regarding organ donation and associated factors among healthcare workers in UKMMC.
Patients and methods: A cross-sectional study was conducted among 255 healthcare workers in UKMMC. Subjects were divided into three groups: doctors, nurses and health assistants. There were 85 participants in each group. A validated 39-item contain self-administered questionnaire was used to assess participants' level of knowledge, attitude and practice regarding organ donation.
Results: The mean score is highest among doctors as compared to nurses and health assistants respectively in terms of knowledge (121.74 (84.0%) ± 12.19; 115.32 (79.5%) ± 14.16; 109.71 (75.7%) ± 13.63, p <0.001), attitude (50.27 (83.8%) ± 5.70; 43.00 (71.7%) ± 6.88; 42.34 (70.6%) ± 6.85, p <0.001) and practice (6.33 (63.3%) ± 1.75; 4.33 (43.3%) ± 2.19; 3.33 (33.3%) ± 2.31, p <0.001). Further analysis showed the attitude and practice towards organ donation were significantly higher among doctors (p=0.001), those with tertiary education (p=0.001), males (p=0.001), the Indian ethnicity (p=0.001), Hindus (p=0.001) and those with a high monthly income (>RM10000) (p=0.001). However, knowledge was significantly associated with younger age (21-30) (p=0.026), being Chinese (p=0.034) and having a moderate monthly income (RM5000-10000) (p=0.001).
Conclusion: The factors which affect attitude and practice are not associated with knowledge. Despite good knowledge, willingness to donate is low when attitude is poor. An organ donation campaign should be conducted to increase attitude and practice among those who have knowledge but are not willing to practise.
An analysis of convalescent plasma unit cost calculation using time-driven activity-based costing (TDABC) method
Authors: Firman Pribadi  , Emy Noerwidayati
Published: May 2024

Introduction: The viral pneumonia disease covid-19 is currently becoming a pandemic throughout the world due to SARS-CoV-2. With a lack of therapy choices for covid-19, convalescent plasma therapy was considered an emergency intervention in some countries. Convalescent plasma was, by unit cost, the most expensive service at the laboratory of Dolopo Hospital, thus easy, practical, and efficient calculation of unit cost was needed. This research aims to analyze the unit cost of convalescent plasma as calculated using the Time-Driven Activity-Based Costing (TDABC) method and to examine the difference between the unit cost of convalescent plasma calculated using the TDABC with the real cost at Dolopo Hospital.
Methods: This qualitative research used a case study approach. The primary data were obtained through observation of convalescent plasma activity, and the secondary data were obtained through interviews related to the data of convalescent plasma cost.
Results: The convalescent plasma unit cost calculated based on the TDABC method was IDR2,287,675 and on real cost was IDR2,250,000. The result of the calculation using the TDABC method was higher than the real cost calculation by IDR36.765.
Conclusion: The research results showed that cost analysis using the TDABC method resulted in a more detailed and accurate calculation that the calculation was activity and time-based.
Hepatitis B vaccine knowledge, perception, and motivation among children and adults in the rural region at Semarang, Indonesia
Authors: Anantyo Dimas Tri , Nency Yetty Movieta , Ardi Sri Suci Ningtyas , Harahap Najma Khairani , Pratama Ivan
Published: May 2024

Background: Hepatitis B is a global health problem with high prevalence, morbidity, and mortality. Knowledge, perception, and motivation for hepatitis B vaccination play significant roles in infection numbers. Thus, this study aimed to investigate the relationship between sociodemographic factors, knowledge, perception, and motivation for hepatitis B vaccination in the rural region of Semarang, Indonesia.
Methods: This cross-sectional study was held in September-October 2019 in the rural region of Semarang, Indonesia. In total, 508 subjects aged 10-40 years participated. The data collected from the questionnaire contains demographic data, knowledge, perception, and motivation for the hepatitis B vaccine. Data analysis using bivariate Chi-Square test.
Results: A total of 508 people met the criteria, 437 respondents (86%) can describe the hepatitis B disease, and 502 respondents (98.8%) agreed with the hepatitis B vaccine. Age significantly affects knowledge and perception of the hepatitis B vaccine (p=0.004; p=0.030). Sex and education significantly relate to knowledge of hepatitis B disease (p=0.022; p=0.025). The most motivation is getting free of charge hepatitis B vaccination (n=223, 43.9%) and participation in scientific development (n=184, 36.2%). One hundred eighty-two people (35.8%), males and 326 females (64.2%) were motivated to get hepatitis vaccination. Age and sex significantly related to the respondent's motivation for the hepatitis B vaccine (p= <0.001; p=0.028).
Conclusion: Knowledge and motivation for hepatitis B vaccination are influenced by age and sex. Older age and females significantly correlate with the reason to have hepatitis B vaccination.
Mesona palustris BL: the potential antioxidant
Authors: Rahmah  , Salimo Harsono , Wasita Brian , Pamungkasari Eti Poncorini , Cilmiaty Risya , Soetrisno
Published: May 2024

Mesona palustris, also known as ‘Black Cincau’ was a plant that was commonly found in East and South East Asian countries. Recently, interest in these Mesona palustris components, such as antioxidants. It can reduce the damage in the cellular aspect either by quenching free radicals or through the chelation of transition metal ions, which reduces their capability to form reactive oxygen species. M.palutris can be composed of more nutraceutical options, including edible jellies. Some previous studies investigated the effective and beneficial extraction process of M. palustris to elucidate the chemical constituents of M.palustris. This plant is also known to have some phenolic compounds, such as flavonoids and tannins. Nowadays, it has been reported to yield many thrilling studies as an antioxidant.
Utilizing information technology for optimizing LBW care: a systematic review
Authors: Romdzati  , Wanda Dessie
Published: May 2024

The incidence of low birth weight (LBW) is still high. Based on data released by UNICEF and WHO, it is estimated that one in seven births is LBW. Due to their physical condition, LBW experienced health problems. This requires integrated management from health professions even collaboration with other scientific disciplines. Along with the times, information technology is widely used in various fields, including in health care. This study aims to identify the use of information technology to improve the quality of care for LBW. This was a systematic review. Five IT products were intended for use by LBW parents, while others were used by health workers. The use of IT in LBW has benefits, including parental self-efficacy, discharged preparedness, and length of stay (LOS). Information technology related to LBW health care has specific usage and the target user. Each has advantages and limitations or disadvantages compared to other similar IT products.
The impact of bullying on adolescent self-concept
Authors: Hidayati Laili Nur , Wahyuni Silfia
Published: May 2024

Introduction: Adolescence is also called the transition period because, at this time, adolescence has not entered childhood but has not yet entered adulthood. During this period, there will be several changes in adolescence. Adolescents who have been victims of bullying will have a long-term impact that will affect their psychological condition and feel depressed and insecure. Adolescence who are victims of bullying will certainly affect their self-concept. Adolescence will feel that he is helpless, unattractive, weak and unwelcome.
Aims: The purpose of this study was to determine the relationship on the impact of bullying on adolescent self-concept.
Methods: This study used a correlational quantitative method with a cross-sectional approach. The variables examined were the impact of bullying and adolescent self-concept. The sample in this study was 62 respondents who were taken by accidental sampling technique. Prior to data collection, the researcher gave informed consent to prospective respondents and had conducted an ethical test.
Results: The results of this study indicate that the level of impact of bullying on respondents in the medium category is 35 respondents (56.5%), a negative self-concept 43 respondents (69.4%). In addition, there is no relationship between the impact of bullying and adolescent self-concept with the p-value of 0.958 (p> 0.05) and r of 0.007 with a very weak interpretation.
Conclusion: The impact of bullying only slightly affects the self-concept of adolescents, besides that self-concept is influenced by other factors such as parenting patterns of parents, peers, physical appearance and self-esteem.
Diet, physical activity and obesity incidence in adolescents with disabilities
Authors: Hidayati Titiek , Suen Mein-Woei , Indriawati Ratna , Akrom
Published: May 2024

Introduction: Nutrients are related to the growth and development of children. In addition to nutrition, physical activity is no less important in the process of child growth and development that can be carried out in the home or school environment. Children with disabilities sometimes can’t get the optimum nutrients required for their body and it is hard to do physical activities. It is necessary to study eating patterns and physical activities and the incidence of obesity in children with disabilities. The purpose of the study was to determine the description of eating patterns, physical activity and the incidence of obesity in children with disabilities.
Methods: The research method used was a quantitative design with a cross sectional approach. Subjects were recruited by purposive sampling technique. Diet was determined by a food frequency questionnaire. Physical activity was measured by the standard Global Physical Activity Questionnaire. Univariate analysis was used to describe the distribution of frequency and percentage. Bivariate analysis was used to determine the relationship of diet and physical activity with the incidence of obesity.
Results: The result is that 50% of Bangunputra Special Educational Needs (SEN) School’s students are obese, 25% are normal, and 25% tend to be thin. The eating pattern of students with disabilities resulted in 43.8% being balanced and the remaining 56.2% consuming excessively on staple foods. In physical activity, 45.2% did physical activity and the remaining 54.5% did not do physical activity. Low physical activity can be caused by children with autism who have motor disorders that can affect them. Parenting patterns are related to socio-economic status, because the majority of parents of Bangunputra SEN School students do not restrain or limit any child's wishes.
Conclusion: The results showed that the incidence of obesity in children with disabilities is related to the knowledge of eating patterns and physical activity. Parents and the school environment play an essential role in providing better care for people with disabilities.
Effects of Tissue Flap on Expression of Vascular Endothelial Growth Factor-C (VEGF-C) as a Marker of Improved Inguinal Lymphatic Circulation on Dissected Mice
Authors: Panigoro Sonar Soni , Kurniawan Doni , Dien Alban , I Gusti Ngurah Gunawan Wibisana  , Devina Adella Halim
Published: May 2024

Background: Radical surgery in cancer patients might result in complications like lymphedema. Tissue transfer procedure and lymphatic reconstruction could be done to manage lymphedema. Few biomarker expressions were identified to be associated with lymphangiogenesis and improved lymphatic system function after dissection. This study aims to evaluate the development of new lymphatic vessels by adding flap tissue after lymphatic dissection, assessed by VEGF-C expression, macrophage infiltration, and fibrotic tissue development.
Methods: This is a non-randomized clinical trial at Animal House Skill Laboratory, Faculty of Medicine, Universitas Indonesia, conducted from January to March 2018. Sprague clawley male mice were aged 8-12 weeks were used and divided into control and trial groups. Each mouse underwent inguinal dissection and was randomized to receive additional flap tissue procedures and then evaluated two months after. Methylene blue dye was used to assess the lymphatic flow. Histopathology and immunohistochemistry examination was used to assess the development of fibrotic tissue. Data analysis was done by using SPSS version 20.0 for Windows.
Results: 18 mice were included in the analysis and divided into two groups. Eight out of 9 mice (88.9%) in the trial group, which received flap tissue, showed lymphatic flow from the visualization of methylene blue, compared to two mice (22.2%) from the control group (p=0.15) two months after surgery. Histopathology examination showed wider fibrotic tissue of the lymphatic system from the trial group (p=0.05). Immunohistochemistry analysis also showed higher VEGF-C (p=0.01) and CD68 expression in the trial group (p=0.15).
Conclusion: The addition of flap tissue might improve lymphatic flow, proven by increased lymphatic circulation and VEGF-C expression.
Pregnancy characteristics of patients with placenta acreta spectrum at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar, Bali-Indonesia during January 2020 - January 2022
Authors: Anak Agung Ngurah Jaya Kusuma  , I Wayan Artana Putra  , I Gde Sastra Winata  , Permadi I Gusti Ngurah Wiranta , William Alexander Setiawan
Published: May 2024

Introduction: Placenta accreta spectrum is a problem during delivery when the placenta is not completely separated from the uterus and is followed by massive obstetric bleeding and can cause postnatal morbidity and mortality. The purpose of this study was to describe the pregnancy characteristics of patients with placenta accreta spectrum at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar, Bali-Indonesia during period 1 January 2020 - 1 January 2022.
Methods: This study is a descriptive study that describes the basic sociodemographic characteristics, ligation procedures, ultrasonographic findings, and histopathology.
Results: A total of 48 patients were sampled in this study, the highest proportion of pregnant women with placenta accreta spectrum with lacuna grade II (39.6%), loss of basal hypoechoic zone (64.6%), myometrial thickness <1 mm (39.6%), anterior placenta location (81.3%), regular vesicouterine border (75%), no exophytic mass (97.9%), bridging vessels (68.8%), no feeding vessels (85.4%), loss of placental basal Doppler image (97.9%), no hypervascularity of the vesicouterine area (66.7%), no lacunae vascular turbulence (83.3%) and the highest PAI score with a value of less than 5.37 (56.3%).
Conclusion: The spectrum of placenta accreta was found with grade II lacunae, loss of basal hypoechoic zone, myometrial thickness <1 mm, anterior placenta location, regular vesicouterine border, no exophytic mass, no bridging vessels, no feeding vessels, loss of placental basal Doppler image, there was no hypervascularity in the vesicouterine area, no vascular lacunae turbulence and the highest PAI score with a value of less than 5.37.
Time to detection of Mycobacterium tuberculosis using culture filtrate H37rv supplementation on MGIT 960 System
Authors: Paweninggalih Resti Enggar , Mertaniasih Ni Made , Koendhori Eko Budi , Soedarsono Soedarsono
Published: May 2024

Background: The fundamental priority program for controlling Tuberculosis (TB) is accurate and rapid diagnosis. Variable Mycobacterium tuberculosis (MTB) phenotypes were discovered in sputum samples from pulmonary TB (PTB) patients. Active replicating bacteria and differentially culturable tubercle bacteria (DCTB) are present in the sputum. Differentially culturable tubercle bacilli did not grow on the standard medium. Culture filtrate (CF) H37Rv supplementation containing resuscitation-promoting factors (Rpfs) has the potential to increase sensitivity and reduce time to detection (TTD) on culture-based diagnostics.
Methods: This study was a true experimental laboratory. A clinical sample was taken from the sputum of 15 PTB patients, which was "MTB detected" by Xpert MTB/RIF assay. Sputum samples were divided into two groups and inoculated on MGIT 960 in one group with CF-H37Rv supplementation and without in the other as standard MGIT medium.
Results: On both standard MGIT medium and MGIT+CF H37Rv, the recovery rate was 100%. Seven samples (47%) show a growth promotion effect with CF H37Rv supplementation (ΔTTD > 10 hours), while eight samples (53%) show no change in TTD (ΔTTD < 10 hours). There is no evidence that CF H37Rv supplementation inhibits growth. Six of the seven samples with ΔTTD > 10 jam (85,7%) were dominated by samples with acid-fast bacilli (AFB) grading 1+, which could be an assumption related to re-treatment PTB cases, chronic cases, treatment stages, TB-HIV, or follow up of treatments.
Conclusion: There was no difference in recovery rate or TTD between standard MGIT medium and MGIT+CF H37Rv. The supplementation of culture filtrate H37Rv has a greater advantage on samples with low bacterial load (AFB 1+).
Diagnostic test thyroid elastography examination and mRNA expression of the Cytokeratin-19 gene to determine the type of thyroid nodule
Authors: Ma’ruf Fauzy , Suanjaya Made Agus , Murtala Bachtiar , Ilyas Muhammad , Hatta Mochammad , Mulyadi Rahmad , Natzir Rosdiana , Idris Irfan , Husni Cangara Muhammad , Muis Mirna , Zainuddin Andi Alfian , Anjarwati Dewi , Aprianturi Wiwik Sari
Published: May 2024

Background: Thyroid nodules are still a health problem today. The incidence of thyroid nodules is still high. Thyroid nodules are found in 60% of the human population. Most thyroid nodules are benign, whereas malignant ones account for only about 10% of cases. Efforts are needed to determine the diagnostic value of ultrasound elastography and cytokeratin -19 biomarkers in determining the type of thyroid nodule.
Methods: This study is a diagnostic test on 42 thyroid nodule patients. Elastography examination using GE Logic 7 expert ultrasound and cytokeratin 19 biomarker examination using cubital vein blood.
Result: The study participant was dominated by 38 women and 4 men. The age range of the study subjects was dominated by the age range less than and up to 40 years with 27 people (64.3%) and at least in the age range more than 60 years with 3 people (7.1%). Elastography's receiver operator characteristics (ROC) curve in determining thyroid nodules found that Elastography's ability to diagnose benign and malignant thyroid nodules was good with an area under curve (AUC) of 0.8409 (84.09%). ROC curve of cytokeratin-19 gene m-RNA expression in determining thyroid nodules found that the ability of cytokeratin-19 gene m-RNA expression in diagnosing benign and malignant thyroid nodules is excellent with an area under curve (AUC) of 0.9795 (97.95%).
Conclusion: Elastography has a good ability to determine the thyroid nodule while Cytokeratin-19 has an excellent ability to determine the type of thyroid nodule.
Does transcutaneous Vagus Nerve Stimulation (tVNS) reduce pain intensity in chronic low back pain patients? A randomized controlled pilot study
Authors: Muhammad Jasman Erwin Halim  , Arfianti Lydia , Pawana I Putu Alit , Melaniani Soenarnatalina
Published: May 2024

Background: Low back pain, if poorly treated, is responsible for a decline in patients’ quality of life. In addition to medication and exercise therapy, transcutaneous vagus nerve stimulation (tVNS) emerges as one of the modalities for chronic pain. Currently, studies on the effect of tVNS on pain intensity, particularly in chronic low back pain cases, are still scarce. This study aims to examine the effect of tVNS in addition to exercise treatment on patients with chronic low back pain.
Methods: Twenty-two patients were randomly assigned to one of two groups: the control group, which included eleven patients who received only exercise therapy, and the intervention group, which included eleven patients who received exercise therapy with tVNS as an additional therapy. The demographic data of the participants and the results of the Numerical Pain Rating Scale (NPRS) were used as outcome measures. Data were collected before and after the two-week treatment period. Safety and adverse events were monitored throughout the study.
Results: The mean NPRS decreased in both groups, with the intervention group decreasing from 5.45 to 1.73 (p < 0.001) and the control group decreasing from 5.82 to 3.27 (p < 0.001). Although the intervention group's average NPRS score decreased more than the control groups, no significant difference was found (p=1.04). Following Cohen's D, the effect size of the intervention group was more significant (2.22) than that of the control group (1.62).
Conclusion: These findings imply that tVNS should be considered an additional therapy for chronic low back pain patients. During the study, no side effects were discovered.
Animal model of contusion compression spinal cord injury by Yasargil aneurysm clip
Authors: Semita I Nyoman , Utomo Dwikora Novembri , Suroto Heri , Gandi Parama
Published: May 2024

Background: Animal spinal cord injury (SCI) models have shown to be invaluable in better understanding the mechanisms related to traumatic SCI and evaluating the effectiveness of experimental therapeutic interventions. The use of clip compression can produce contusion–compression SCI models in rats with clinical features in the form of total paralysis, retention of micturition, and retention of defecation. This study aimed to validate the effects of the duration of Yasargil aneurysm clip application on the formation of SCI models with analyzed neuropathic pain, locomotor function, histology, and tumor necrosis factor (TNF-α).
Methods: We did true experimental study investigated 20 Sprague Dawley divided into normal, 30-second, 60-second, and 90-second groups. Contusion–compression model of SCI post-laminectomy was done in 0, 30, 60, and 90 seconds using a Yasargil aneurysm clip, with a force of 65g (150kDyne). Data were analyzed using SPSS version 25 for Windows.
Result: We found that the locomotor expression did not indicate total paralysis after compression durations of 0 and 30 seconds, while compression durations of 60 and 90 seconds could result in total paralysis. There was no significant difference in the mean BBB scores between the compression durations of 60 and 90 seconds (p=1.000). In addition, there was no significant difference in the mean RGS value between the 60-second model group and the 90-second model group on days 21 and 28 (p=1.000; p=0.900). The histological pictures at compression durations of 60 and 90 seconds show severe damage to spinal cord continuity. There was no significant difference in the mean value of TNF-α between the duration compressions of 60 and 90 seconds (p=0.937).
Conclusion: The use of Yasargil aneurysm clips for 60 and 90 seconds could produce a contusion–compression SCI model with expressions of neuropathic pain, locomotor function, histology, and pro-inflammatory cytokine.
Acute Lymphoblastic Leukemia (ALL)-L2 in an adult woman: a case report
Authors: Suwandari Ni Luh Ayu , Lestari Anak Agung Wiradewi , Wande I Nyoman , Wirawati Ida Ayu Putri , Prabawa I Putu Yuda
Published: May 2024

Background: Acute lymphoblastic leukemia (ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace normal hematopoietic cells without developing into normal B and T cells. Acute lymphoblastic leukemia (ALL) is the most common leukemia in pediatric patients, accounting for up to 80% of cases in children and less frequently in adults.
Case Presentation: A 47-year-old woman complained of fever, feeling weak and dizzy, and also complained that if she spits, there has been blood since 7 days ago. A complete blood count showed leukocytosis, anemia, and thrombocytopenia. Bone marrow appearance corresponds to Acute Lymphoblastic Leukemia (ALL-L2) with 60% lymphoblast infiltration and heterogeneous size into the bone marrow. The immunophenotyping results showed a population of blasts expressing CD79a positive, CD19 positive, and CD34 positive with an ALL-B Lineage effect. During treatment, the patient experienced a worsening and was declared dead.
Conclusion: We report a case of an adult woman with a diagnosis of ALL L2. The diagnosis is based on clinical symptoms, laboratory examination, peripheral blood smear, bone marrow aspiration, and immunophenotyping examination.