bluuebunny/crossref_metadata_2025 huggingface dataset:
GAM-MDR: probing miRNA–drug resistance using a graph autoencoder based on random path masking
Authors: Zhou Zhecheng , Du Zhenya , Jiang Xin , Zhuo Linlin , Xu Yixin , Fu Xiangzheng , Liu Mingzhe , Zou Quan
Published: February 2024

MicroRNAs (miRNAs) are found ubiquitously in biological cells and play a pivotal role in regulating the expression of numerous target genes. Therapies centered around miRNAs are emerging as a promising strategy for disease treatment, aiming to intervene in disease progression by modulating abnormal miRNA expressions. The accurate prediction of miRNA–drug resistance (MDR) is crucial for the success of miRNA therapies. Computational models based on deep learning have demonstrated exceptional performance in predicting potential MDRs. However, their effectiveness can be compromised by errors in the data acquisition process, leading to inaccurate node representations. To address this challenge, we introduce the GAM-MDR model, which combines the graph autoencoder (GAE) with random path masking techniques to precisely predict potential MDRs. The reliability and effectiveness of the GAM-MDR model are mainly reflected in two aspects. Firstly, it efficiently extracts the representations of miRNA and drug nodes in the miRNA–drug network. Secondly, our designed random path masking strategy efficiently reconstructs critical paths in the network, thereby reducing the adverse impact of noisy data. To our knowledge, this is the first time that a random path masking strategy has been integrated into a GAE to infer MDRs. Our method was subjected to multiple validations on public datasets and yielded promising results. We are optimistic that our model could offer valuable insights for miRNA therapeutic strategies and deepen the understanding of the regulatory mechanisms of miRNAs. Our data and code are publicly available at GitHub:https://github.com/ZZCrazy00/GAM-MDR.
Mortality and hyperkalaemia-associated hospitalisation in patients with chronic kidney disease: comparison of sodium zirconium cyclosilicate and sodium/calcium polystyrene sulfonate
Authors: Onogi Chikao , Watanabe Yu , Tanaka Akihito , Furuhashi Kazuhiro , Maruyama Shoichi
Published: February 2024

Background

Sodium zirconium cyclosilicate (SZC), a novel drug used for treating hyperkalaemia, is effective in reducing serum potassium levels. The effects of potassium adsorbents on the mortality and hyperkalaemia-associated hospitalisation rates remain unclear. We aimed to examine how mortality and hyperkalaemia-associated hospitalisation rates vary with usage of various potassium adsorbents.

Methods

This retrospective study used patients’ data between April 2008 and August 2021 obtained from a large-scale Japanese medical claims database. Consecutive patients with chronic kidney disease (CKD) prescribed potassium adsorbents were enrolled and divided into three groups according to the adsorbent type [SZC, calcium polystyrene sulfonate (CPS), and sodium polystyrene sulfonate (SPS)] and were observed for 1 year. The primary outcome was a composite of mortality and hyperkalaemia-associated hospitalisation.

Results

In total, 234, 54 183, and 18 692 patients were prescribed SZC, CPS, and SPS, respectively. The SZC group showed a higher event-free survival rate than the other two groups. The hazard ratio for the primary outcome in the CPS and SPS groups was similar in the analyses of the subgroups of patients who did not receive renal replacement therapy and those who received haemodialysis. The SZC group had a higher renin-angiotensin-aldosterone system inhibitors (RAASi) continuation rate compared to CPS and SPS groups, the difference being especially significant for SPS.

Conclusions

This real-world study demonstrated the therapeutic effect of SZC in reducing mortality and hyperkalaemia-associated hospitalisations. The high RAASi continuation rate in the SZC group might be a contributing factor for improvement of the primary outcome.
Exploring the impact and utility of genomic sequencing in established CKD
Authors: Jefferis Julia , Mallett Andrew J
Published: February 2024

Clinical genetics is increasingly recognized as an important area within nephrology care. Clinicians require awareness of genetic kidney disease to recognize clinical phenotypes, consider use of genomics to aid diagnosis, and inform treatment decisions. Understanding the broad spectrum of clinical phenotypes and principles of genomic sequencing is becoming increasingly required in clinical nephrology, with nephrologists requiring education and support to achieve meaningful patient outcomes. Establishment of effective clinical resources, multi-disciplinary teams and education is important to increase application of genomics in clinical care, for the benefit of patients and their families. Novel applications of genomics in chronic kidney disease include pharmacogenomics and clinical translation of polygenic risk scores. This review explores established and emerging impacts and utility of genomics in kidney disease.
Habitat-specific patterns of bacterial communities in a glacier-fed lake on the Tibetan Plateau
Authors: Guo Xuezi , Yan Qi , Wang Feng , Wang Wenqiang , Zhang Zhihao , Liu Yongqin , Liu Keshao
Published: February 2024

Different types of inlet water are expected to affect microbial communities of lake ecosystems due to changing environmental conditions and the dispersal of species. However, knowledge of the effects of changes in environmental conditions and export of microbial assemblages on lake ecosystems is limited, especially for glacier-fed lakes. Here, we collected water samples from the surface water of a glacier-fed lake and its two fed streams on the Tibetan Plateau to investigate the importance of glacial and non-glacial streams as sources of diversity for lake bacterial communities. Results showed that the glacial stream was an important source of microorganisms in the studied lake, contributing 45.53% to the total bacterial community in the lake water, while only 19.14% of bacterial community in the lake water was seeded by the non-glacial stream. Bacterial communities were significantly different between the glacier-fed lake and its two fed streams. pH, conductivity, total dissolved solids, water temperature and total nitrogen had a significant effect on bacterial spatial turnover, and together explained 36.2% of the variation of bacterial distribution among habitats. Moreover, bacterial co-occurrence associations tended to be stronger in the lake water than in stream habitats. Collectively, this study may provide an important reference for assessing the contributions of different inlet water sources to glacier-fed lakes.
Mutational Signatures in Wild Type Escherichia coli Strains Reveal Predominance of DNA Polymerase Errors
Authors: Garushyants Sofya K , Sane Mrudula , Selifanova Maria V , Agashe Deepa , Bazykin Georgii A , Gelfand Mikhail S
Published: February 2024

While mutational processes operating in the Escherichia coli genome have been revealed by multiple laboratory experiments, the contribution of these processes to accumulation of bacterial polymorphism and evolution in natural environments is unknown. To address this question, we reconstruct signatures of distinct mutational processes from experimental data on E. coli hypermutators, and ask how these processes contribute to differences between naturally occurring E. coli strains. We show that both mutations accumulated in the course of evolution of wild-type strains in nature and in the lab-grown nonmutator laboratory strains are explained predominantly by the low fidelity of DNA polymerases II and III. By contrast, contributions specific to disruption of DNA repair systems cannot be detected, suggesting that temporary accelerations of mutagenesis associated with such disruptions are unimportant for within-species evolution. These observations demonstrate that accumulation of diversity in bacterial strains in nature is predominantly associated with errors of DNA polymerases.
A mutation in the brassinosteroid biosynthesis gene CpDWF5 disrupts vegetative and reproductive development and the salt stress response in squash (Cucurbita pepo)
Authors: Alonso Sonsoles , Cebrián Gustavo , Gautam Keshav , Iglesias-Moya Jessica , Martínez Cecilia , Jamilena Manuel
Published: February 2024

A Cucurbita pepo mutant with multiple defects in growth and development has been identified and characterized. The mutant dwfcp displayed a dwarf phenotype with dark green and shrinking leaves, shortened internodes and petioles, shorter but thicker roots and greater root biomass, and reduced fertility. The causal mutation of the phenotype was found to disrupt gene Cp4.1LG17g04540, the squash orthologue of the Arabidopsis brassinosteroid (BR) biosynthesis gene DWF5, encoding for 7-dehydrocholesterol reductase. A single nucleotide transition (G > A) causes a splicing defect in intron 6 that leads to a premature stop codon and a truncated CpDWF5 protein. The mutation co-segregated with the dwarf phenotype in a large BC1S1 segregating population. The reduced expression of CpDWF5 and brassinolide (BL) content in most mutant organs, and partial rescue of the mutant phenotype by exogenous application of BL, showed that the primary cause of the dwarfism in dwfcp is a BR deficiency. The results showed that in C. pepo, CpDWF5 is not only a positive growth regulator of different plant organs but also a negative regulator of salt tolerance. During germination and the early stages of seedling development, the dwarf mutant was less affected by salt stress than the wild type, concomitantly with a greater upregulation of genes associated with salt tolerance, including those involved in abscisic acid (ABA) biosynthesis, ABA and Ca2+ signaling, and those coding for cation exchangers and transporters.
Life cycle analysis (cost and environmental) of different renewable natural gas from waste procedures based on a multivariate decision-making approach: a comprehensive comparative analysis
Authors: Nejati Mobin Ghasempour , Kamali Seyedeh Elham , Zoqi Mohamad Javad , Sami Fatima Moayad , Al-hussainawy Mohammed Kassim , Fooladi Hadi
Published: February 2024

This article presents a framework that focuses on structural considerations within gas networks to evaluate and rank various feasibility options for renewable natural gas (RNG) cases. Specifically, the analysis examines and compares a range of methods for producing RNG using natural gas from waste (NGFW), considering different types of waste as feedstock. To analyze and evaluate the different methodologies, the article uses a decision architecture based on life cycle analysis (cost and environmental). These tools are used to determine the most favorable path for the NGFW process. The preferred pathway is identified by considering a range of decision scenarios that take into account variables such as geographical conditions, the availability of various feedstocks and the different stakeholders’ priorities. The results show that according to the economically neutral scenarios and those that favor economic considerations, the pathway involving RNG generation from landfill gas coupled with a pressure swing adsorption (PSA) upgrading technology emerges as the optimum choice. Conversely, in a scenario where environmental sustainability is a priority, the process that emerges as most advantageous is the use of animal manure with the addition of a PSA upgrading unit. The designed structure can be adapted to different regions, each with its own unique geographical features and feedstock resources, and can be customized to meet the varying interests of stakeholders. Based on both parametric assessments and analytical interpretations, this article not only identifies optimal pathways but also provides a set of recommendations and strategies aimed at improving economic behavior.
Development status and application analysis of new energy photovoltaic power generation energy market based on artificial intelligence
Authors: Dai LuPing , Shen JiaYi , Zhang FeiFei
Published: February 2024

With the rapid development of artificial intelligence, it is present in various fields. With the progress of the economy, existing energy has been unable to meet the growing demand of people, and the development of renewable resources to resolve the energy crisis is our common goal. In recent years, my country’s scientific and technological levels have greatly improved, and new energy photovoltaic power generation has also made great progress. The increasingly mature photovoltaic power generation technology in my country can effectively meet the demand for energy consumption and greatly reduce the waste of nonrenewable resources. This article mainly discusses the development status and application analysis of the new energy photovoltaic power generation energy market under the background of artificial intelligence and promotes the effective development of new energy in my country through the analysis of the new energy photovoltaic power generation energy market.
Certificates of confidentiality: privileging research data
Authors: Wolf Leslie E , Ram Natalie , Contreras Jorge , Beskow Laura M
Published: February 2024

With the Supreme Court’s decision in Dobbs, reproductive research now joins other sensitive research topics that present legal risks to research participants, underscoring the role of Certificates in protecting them. Yet, stakeholders question whether Certificates will hold up in court. In this article, we describe the essential arguments supporting Congress’s regulation of biomedical research and, thus, Certificates, under its authority to regulate interstate commerce. Our analysis should reassure researchers and Institutional review boards who rely on Certificates to protect the confidentiality of research participants’ data. We conclude with recommendations for stakeholders based on our analysis.
Delayed complications from polyacrylamide gel breast fillers: a case report
Authors: Tang Patrick , Ng Suat L
Published: February 2024

In the late nineties, polyacrylamide gel (PAAG) gained popularity in China as a soft tissue filler for breast augmentation and contouring, but was banned 10 years later due to the increasing incidence of complications. We report a case of PAAG complication that occurred 20 years after the initial injection, where the patient had significant unilateral breast swelling and an intracapsular lesion. Surgical removal of the breast filler and immediate breast reconstruction was successfully performed, and histology confirmed a benign breast lesion. These findings highlight the importance of clinical awareness of PAAG breast filler complications.
Medication Trends in the Military: A Comparative Analysis of Prescribing Patterns Among Service Members Seen by a Pharmacist and Implications for Medical Readiness
Authors: Costantino Ryan C , Gressler Laura E , Zarzabal Lee Ann , Vasquez Cynthia M , Juneau Richard
Published: February 2024

Introduction

Medications play a critical role supporting the health of military service members. Little is known about the broad use of medications prescribed to this population. Active duty service members (ADSMs), while often younger and having fewer diagnosed comorbid conditions, face unique health challenges that benefit from pharmacotherapy. Understanding prescribing patterns is instrumental to illuminate potential areas for research and to guide education so that military health care professionals can maintain competency, improve outcomes, and support medical readiness. This study aimed to characterize commonly dispensed medications among ADSMs and to compare these prescriptions with those of the general population.

Materials and Methods

A retrospective, cross-sectional analysis using data extracted contained in the Military Health System Information Platform focused on ADSMs who consulted with a clinical pharmacist during the 2019 fiscal year. Descriptive statistics were used to summarize patient and prescription data. The 100 most frequently prescribed medications and 20 most frequently prescribed therapeutic classes were identified. Analyses were performed using Statistical Analysis System (SAS) software, and a non-metric multidimensional scaling plot was generated in R to illustrate the relationships between the 20 most frequently used therapeutic classes and the branches of service.

Results

The study analyzed 719,788 prescriptions for 30,012 service members, revealing a high prescription rate for pain, inflammation, and psychiatric condition treatments. Antidepressants and nonsteroidal anti-inflammatory drugs were among the most commonly prescribed across all military branches. Some medication uses varied, which may indicate distinct needs within different service branches.

Conclusions

Understanding medication patterns among ADSMs may be able to help health care professionals proactively address pharmacological challenges and optimize pharmaceutical use in this unique population. This knowledge can also aid in the development of training modules focused on medication side effects, interactions, counseling, and implications on military deployment for the most commonly used medications. Future examination into prescribing cascades and medication use related to proton-pump inhibitors, docusate, benzonatate, and muscle relaxants may identify opportunities to provide better care or lower cost.
Updates in the management of cancer therapy-related hypertension
Authors: Gupta Prerna , Canonico Mario Enrico , Faaborg-Andersen Christian , Prabhu Nicole , Kondapalli Lavanya , Quintana Raymundo A.
Published: February 2024

Purpose of review

To provide a comprehensive review of hypertension among patients with cancer. Several cancer therapies cause hypertension which has resulted in a growing and vulnerable population of patients with difficult to control hypertension which has significant downstream effects.

Recent findings

Hypertension affects up to 50% of cancer patients and higher comorbidity when compared to the general population. Many anticancer therapies can cause hypertension through their treatment effect. Antihypertensive treatment is crucial given cardiovascular mortality is a leading cause of death among cancer patients. It is already known that hypertension is poorly controlled in the general population, and there are additional challenges in management among patients with cancer. Patients with cancer suffer from multimorbidity, are on multiple medications creating concern for drug interactions, and often have blood pressure lability, which can worsen clinical inertia among patients and their providers. It is crucial to effectively treat hypertension in cancer patients to mitigate downstream adverse cardiovascular events.

In recent years, there have been significant changes in management guidelines of hypertension and simultaneously as influx of new cancer therapeutics. We provide an update on hypertension treatment among patients with cancer on different chemotherapeutic agents.
Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis
Authors: He Jie , Ni Zhijie , Li Zhongbo
Published: February 2024

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that primarily affects the mucosal layer of the colon (large intestine). However, the relationship between Intercellular Adhesion Molecule-1 (ICAM1), SELL and UC is unclear. The UC datasets, GSE87466 and GSE36807, were downloaded from the gene expression omnibus database. The R package limma was utilized to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis was conducted. The construction and analysis of protein–protein interaction network, functional enrichment analysis, gene set enrichment analysis, and comparative toxicogenomics database analysis were performed. TargetScan was employed to screen miRNAs regulating central DEGs. Western blot (WB) was used to verify. A total of 2118 DEGs were identified in our study. Gene ontology analysis indicated their enrichment primarily in immune system processes, cellular responses to chemical stimuli, responses to organic substances, responses to external stimuli, and immune responses. Kyoto Encyclopedia of Genes and Genomes analysis revealed that the target cells were mainly enriched in chemokine signaling pathways and TNF signaling pathways. Gene set enrichment analysis enrichment analysis showed significant enrichment in chemokine signaling pathways and cell adhesion molecules. In the Metascape enrichment project, gene ontology terms included regulation of cell activation and positive regulation of immune response. Through the construction and analysis of a protein–protein interaction network, we identified 11 core genes (ICAM1, SELL, CD44, CD40, CCR7, CXCL8, CD19, CCL4, CD274, IL7R, IL1B). We found that the core genes (ICAM1, SELL) were highly expressed in UC samples and lowly expressed in normal samples, suggesting their potential regulatory roles in UC. These core genes were associated with lymphoproliferative disorders, inflammation and necrosis. WB results confirmed the high expression of ICAM1 and SELL in UC. ICAM1 and SELL are highly expressed in UC, and the higher the ICAM1 and SELL genes, the worse the prognosis.
Expanded Indications for Nipple-Sparing Mastectomy and Immediate Breast Reconstruction in Patients Older Than 60 Years
Authors: King Caroline A. , Shaposhnik Guy , Sayyed Adaah A. , Bartholomew Alex J. , Bozzuto Laura M. , Sosin Michael , Greenwalt Ian T. , Fan Kenneth L. , Song David , Tousimis Eleni A.
Published: February 2024

Introduction

Although nipple-sparing mastectomy (NSM) and immediate breast reconstruction (IBR) have long been praised for excellent cosmetic results and the resultant psychosocial benefits, the feasibility and safety of these procedures in patients older than 60 years have yet to be demonstrated in a large population.

Methods

Patients undergoing NSM with or without IBR at the MedStar Georgetown University Hospital between 1998 and 2017 were included. Patient demographics, surgical intervention, and complication and recurrence events were retrieved from electronic medical records. Primary outcomes were recurrence and complication rates by age groups older and younger than 60 years.

Results

There were 673 breasts from 397 patients; 58 (8.6%) older than 60 years and 615 (91.4%) younger than 60 years with mean follow-up of 5.43 (0.12) years. The mean age for those older than 60 was 63.9 (3.3) years, whereas that for those younger than 60 was 43.1 (7.9) years (P < 0.001). The older than 60 group had significantly higher prevalence of diabetes, rates of therapeutic (vs prophylactic) and unilateral (vs bilateral) NSM, and mastectomy weight. However, there were no significant differences by age group in complication rates or increased risk of locoregional or distant recurrence with age.

Conclusions

Based on similar complication profiles in both age groups, we demonstrate safety and feasibility of both NSM and IBR in the aging population. Despite increased age and comorbidity status, appropriately selected older women were able to achieve similar outcomes to younger women undergoing NSM with or without IBR.
Pediatric Plastic Surgery in the COVID-19 Era
Authors: Levy Lior , Villavisanis Dillan F. , Sarosi Alex J. , Taub Peter J.
Published: February 2024

The COVID-19 pandemic has forced the healthcare system to adopt novel strategies to treat patients. Pediatric plastic surgeons are uniquely exposed to high rates of infections during examinations and surgeries via aerosol-generating procedures, in part because of the predilection of viral particles for the nasal cavities and pharynx. Telemedicine has emerged as a useful virtual medium for encouraging prolonged patient follow-up while maintaining physical distance. It has proven beneficial in mitigating infection risks while decreasing the financial burden on patients, their families, and healthcare teams. New trends driven by the pandemic added multiple elements to the patient-physician relationship and have left a lasting impact on the field of pediatric plastic surgery in clinical guidelines, surgical care, and patient outcomes. Lessons learned help inform pediatric plastic surgeons on how to reduce future viral infection risk and lead a more appropriately efficient surgical team depending on early triage.
Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders
Authors: Abdel Aziz Karim , Mohd Ahmed Hind , Stip Emmanuel , Aly El-Gabry Dina
Published: February 2024

The risk of metabolic syndrome (MetS) has been attributed to antipsychotic use in psychiatric patients. To date, there is limited data on the relationship between antipsychotic polypharmacy and MetS in patients with schizophrenia, schizoaffective disorder and bipolar disorder. Therefore, we aimed to investigate the rate of MetS in patients with these disorders receiving antipsychotic monotherapy and polypharmacy. We conducted a cross-sectional study on patients seen between January 2017 and December 2020, collecting data on the class, type, route of administration and number of antipsychotics received. We used the American Association of Clinical Endocrinology criteria to diagnose MetS. We included 833 subjects of whom 573 (68.8%) received antipsychotic monotherapy and 260 (31.2%) received polypharmacy. Overall, 28.6% (N = 238) had MetS with no statistical difference between the two groups. Diastolic blood pressure and receiving olanzapine were significant predictors for developing MetS. In conclusion, our study found no significant difference in the rate of MetS between antipsychotic monotherapy and polypharmacy. A number of variables were significant predictors for MetS. Our findings were consistent with other studies and warrant the need for careful choice of antipsychotics and regular screening and management of abnormal metabolic parameters.
Baculovirus entry into the central nervous system of
Spodoptera exigua
caterpillars is independent of the viral protein tyrosine phosphatase
Authors: Gasque Simone N. , Han Yue , van der Ham Iris , van Leeuwen Dorothy , van Oers Monique M. , Haverkamp Alexander , Ros Vera I. D.
Published: February 2024

Neuroparasitism concerns the hostile take-over of a host's nervous system by a foreign invader, in order to alter the behaviour of the host in favour of the parasite. One of the most remarkable cases of parasite-induced host behavioural manipulation comprises the changes baculoviruses induce in their caterpillar hosts. Baculoviruses may manipulate caterpillar behaviour in two ways: hyperactivity (increased movement in the horizontal plane) and/or tree-top disease (movement to elevated levels in the vertical plane). Those behavioural changes are followed by liquefaction and death of the caterpillar. In Autographa californica multiple nucleopolyhedrovirus (AcMNPV)-infected
Spodoptera exigua
caterpillars, an enzymatic active form of the virally encoded protein tyrosine phosphatase (PTP) is needed for the expression of hyperactivity from 3 days post infection (dpi). Using eGFP-expressing recombinant AcMNPV strains, we show that infection of the caterpillar's central nervous system (CNS) can be observed primarily from 3 dpi onwards. In addition, we demonstrate that the structural and enzymatic function of PTP does not play a role in infection of the CNS. Instead we show that the virus entered the CNS via the trachea, progressing caudally to frontally through the CNS and that the infection progressed from the outermost cell layers towards the inner cell layers of the CNS, in a PTP independent manner. These findings help to further understand parasitic manipulation and the mechanisms by which neuroparasites infect the host nervous system to manipulate host behaviour.
Ecological functions of fungal sesquiterpenes in the food preference and fitness of soil Collembola
Authors: Slonka Matthäus , Vosteen Ilka , Mendoza-Mendoza Artemio , Rostás Michael
Published: February 2024

Volatile organic compounds (VOCs) emitted by fungi play a key role in locating and selecting hosts for fungivorous arthropods. However, the ecological functions of many common VOC classes, such as sesquiterpenes, remain unknown. Mutants of
Trichoderma virens
, defective in the emission of most sesquiterpenes owing to the deletion of the terpene cyclase
vir4
, were used to evaluate the role of this compound class in the food preference and fitness of the soil Collembola
Folsomia candida.
Choice experiments with and without direct contact with fungal mycelium revealed that Collembola were preferentially attracted to
Δvir4
mutants impaired in sesquiterpene synthesis compared to wild-type
T. virens
. Grazing by
F. candida
on the sesquiterpene deficient
T. virens
strain had no effect on Collembola survival, reproduction and growth compared to wild-type
T. virens
. The results suggest that sesquiterpenes play an important role in fungal defence as repellents, but not as deterrents or toxins, against fungivorous Collembola. Our research contributes to the understanding of ecological interactions between fungi and fungivorous arthropods, providing insights into the specific ecological functions of sesquiterpenes. The study has implications for chemical ecology and the dynamics of multitrophic interactions in soil ecosystems.
Modelling the emergence of social-bird biological controls to mitigate invasions of the spotted lanternfly and similar invasive pests
Authors: Strömbom Daniel , Crocker Amanda , Gery Alison , Tulevech Grace , Sands Autumn , Ward Kelly , Pandey Swati
Published: February 2024

The spotted lanternfly is an emerging global invasive insect pest. Due to a lack of natural enemies where it is invasive, human intervention is required. Extensive management has been applied but the spread continues. Recently, the idea of bird-based biological controls has re-emerged and shown effective in studies. However, it is questionable, if birds are able to effectively control unfamiliar and occasionally toxic invasive pests in short timeframes. Unless, perhaps, the birds are effective social learners and toxicity of the invaders is rare. Here, we introduce a mathematical model for social learning in a great tit-like bird to investigate conditions for the emergence of a collective biological control of a pest that is occasionally toxic, like the lanternfly. We find that the social observation rate relative to the proportion of toxic lanternfly dictate when collective biological controls will emerge. We also implement the social learning model into a model of collective motion in bird-like animals, and find that it produces results consistent with the mathematical model. Our work suggests that social birds may be useful in managing the spotted lanternfly, and that removing the toxicity-inducing preferred host of the lanternfly should be a priority to facilitate this.
An ascomycete H4 variant with an unknown function
Authors: Flipphi Michel , Harispe María Laura , Hamari Zsuzsanna , Kocsubé Sándor , Scazzocchio Claudio , Ramón Ana
Published: February 2024

Histone variants leading to altered nucleosome structure, dynamics and DNA accessibility occur frequently, albeit rarely for H4. We carried out a comprehensive
in silico
scrutiny of fungal genomes, which revealed the presence of a novel H4 variant (H4E) in the ascomycetes, throughout the Pezizomycotina, in basal species of the Taphrinomycotina and also in the Glomeromycota. The coding cognate genes show a specific intron/exon organization, different from H4 canonical genes. H4Es diverge from canonical H4s mainly in the N- and C-terminal extensions, showing marked differences in the distribution and number of Lys and Arg residues, which may result in novel post-translational modifications. In
Aspergillus nidulans
(Pezizomycotina, Eurotiomycetes) the H4E variant protein level is low in mycelia. However, the encoding gene is well expressed at 37°C under nitrogen starvation. H4E localizes to the nucleus and interacts with H3, but its absence or overexpression does not result in any detectable phenotype. Deletion of only one of the of the two canonical H4 genes results in a strikingly impaired growth phenotype, which indicates that H4E cannot replace this canonical histone. Thus, an H4 variant is present throughout a whole subphylum of the ascomycetes, but with hitherto no experimentally detectable function.
Asymptotic analysis of conversion-limited phase separation
Authors: Bressloff Paul C.
Published: February 2024

Liquid–liquid phase separation plays a major role in the formation and maintenance of various membrane-less subcellular structures in the cytoplasm and nucleus of cells. Biological condensates contain enhanced concentrations of proteins and RNA, many of which can be continually exchanged with the surrounding medium. Coarsening is an important step in the kinetics of phase separation, whereby an emulsion of polydisperse condensates transitions to a single condensate in thermodynamic equilibrium with a surrounding dilute phase. A key feature of biological phase separation is the co-existence of multiple condensates over significant time scales, which is consistent with experimental observations showing a slowing of coarsening rates. It has recently been proposed that one rate limiting step could be the slow interfacial conversion of a molecular constituent between the dilute and dense phases. In this paper, we analyse conversion-limited phase separation within the framework of diffusion in singularly perturbed domains, which exploits the fact that biological condensates tend to be much smaller than the size of a cell. Using matched asymptotic analysis, we solve the quasi-static diffusion equation for the concentration in the dilute phase, and then derive kinetic equations for the slow growth/shrinkage of the condensates. This provides a systematic way of obtaining corrections to mean-field theory that take into account the geometry of the cell and the locations of all the condensates.
The impact of sterility-mortality tolerance and recovery-transmission trade-offs on host–parasite coevolution
Authors: Singh Prerna , Best Alex
Published: February 2024

Understanding the coevolutionary dynamics of hosts and their parasites remains a major focus of much theoretical literature. Despite empirical evidence supporting the presence of sterility-mortality tolerance trade-offs in hosts and recovery-transmission trade-offs in parasites, none of the current models have explored the potential outcomes when both trade-offs are considered within a coevolutionary framework. In this study, we consider a model where the host evolves sterility tolerance at the cost of increased mortality and the parasite evolves higher transmission rate at the cost of increased recovery rate (reduced infection duration), and use adaptive dynamics to predict the coevolutionary outcomes under such trade-off assumptions. We particularly aim to understand how our coevolutionary dynamics compare with single species evolutionary models. We find that evolutionary branching in the host can drive the parasite population to branch, but that cycles in the population dynamics can prevent the coexisting strains from reaching their extremes. We also find that varying crowding does not impact the recovery rate when only the parasite evolves, yet coevolution reduces recovery as crowding intensifies. We conclude by discussing how different host and parasite trade-offs shape coevolutionary outcomes, underscoring the pivotal role of trade-offs in coevolution.
Dual effects of time length as experiential marketing elements in We-media videos
Authors: Li Shiqi
Published: February 2024

Purpose

This study aims to uncover the underlying mechanism between the time length of We-media videos and customer satisfaction (CS)/participation (CP) based on experiential marketing theory.

Design/methodology/approach

Two datasets were collected from Bilibili; 308 data were used with bootstrapping for multiple linear regressions (MLR) to test the hypotheses, and 2,670 data were used for structural equation modelling (SEM) to verify robustness.

Findings

Videos’ time length acts as both a price and provision element of experiential marketing. As a price element, its linear term affects CS negatively but CP positively. As a provision element, its quadratic term affects CS positively but CP negatively.

Practical implications

Marketing management personnel and video creators at Bilibili could optimise videos’ time length as suggested. We-media video platforms should encourage high-quality videos with sufficient time lengths to improve CS. Video creators could balance CS and CP, as suggested.

Originality/value

This research proposed platform, provision, price and propagation as experiential marketing elements concerning experiences in online virtual encounters. It found CS was affected positively by provision but negatively by price, whereas the opposite is true for CP. Time length affects CS/CP as both a price and provision element, which may explain the neglect of significant relationships between the time length and marketing performances of videos.
Exploring virtual goods purchase intentions: an integrated SEM-NCA approach in online gaming
Authors: Mkedder Nadjim , Bakır Mahmut , Aldhabyani Yaser , Ozata Fatma Zeynep
Published: February 2024

Purpose

Virtual goods consumption has risen dramatically in recent years. Recognizing the benefits of virtual goods in generating revenue for online game companies, marketers strive to understand the motives behind virtual goods purchases. We investigated the direct and indirect effects of functional, emotional, and social values through player satisfaction on purchase intention toward virtual goods among online players.

Design/methodology/approach

In total, we surveyed 332 online game players utilizing a structured questionnaire. We employed a multi-analytic approach combining partial least squares structural equation modeling (PLS-SEM) and necessary condition analysis (NCA) to examine the proposed relationships.

Findings

The findings show that all dimensions of value and player satisfaction significantly affect the intention to acquire virtual goods. However, social value does not exert a significant effect on player satisfaction. Moreover, we confirmed that player satisfaction mediates the relationships between functional value, emotional value, and purchase intention. Furthermore, NCA results indicated that all predictors in the model are necessary conditions of purchase intention for virtual goods.

Originality/value

These findings contribute to an enhanced understanding of purchase intentions among online game players from a symmetric (PLS-SEM) and asymmetric (NCA) perspective by proposing a multi-analytic approach.
Light field image coding using a residual channel attention network–based view synthesis
Authors: Liu Faguo , Zhang Qian , Yan Tao , Wang Bin , Gao Ying , Hou Jiaqi , Yuan Feiniu
Published: February 2024

Purpose

Light field images (LFIs) have gained popularity as a technology to increase the field of view (FoV) of plenoptic cameras since they can capture information about light rays with a large FoV. Wide FoV causes light field (LF) data to increase rapidly, which restricts the use of LF imaging in image processing, visual analysis and user interface. Effective LFI coding methods become of paramount importance. This paper aims to eliminate more redundancy by exploring sparsity and correlation in the angular domain of LFIs, as well as mitigate the loss of perceptual quality of LFIs caused by encoding.

Design/methodology/approach

This work proposes a new efficient LF coding framework. On the coding side, a new sampling scheme and a hierarchical prediction structure are used to eliminate redundancy in the LFI's angular and spatial domains. At the decoding side, high-quality dense LF is reconstructed using a view synthesis method based on the residual channel attention network (RCAN).

Findings

In three different LF datasets, our proposed coding framework not only reduces the transmitted bit rate but also maintains a higher view quality than the current more advanced methods.

Originality/value

(1) A new sampling scheme is designed to synthesize high-quality LFIs while better ensuring LF angular domain sparsity. (2) To further eliminate redundancy in the spatial domain, new ranking schemes and hierarchical prediction structures are designed. (3) A synthetic network based on RCAN and a novel loss function is designed to mitigate the perceptual quality loss due to the coding process.
Supporting teachers’ professional development in the social classroom dynamics domain with lesson study
Authors: Pronk Jeroen , Goei Sui Lin , Bosma Tirza , Jongejan Wilma
Published: February 2024

Purpose

Despite their pivotal role in classroom social dynamics, teachers are not always aware of, and/or do not know how to respond to, bottlenecks in these dynamics. This study investigated the effectiveness of the Social Classroom Dynamics Intervention with Lesson Study (SKILS, acronym of the Dutch program name) in supporting teachers with regards to improving their classrooms' social dynamics.

Design/methodology/approach

A sample of Dutch secondary school classrooms was divided into five SKILS classrooms (n = 86; 53.5% boys; Mage-T0 = 13.62 years and SD = 1.02 years) and nine control classrooms (n = 156; 50.6% boys; Mage-T0 = 13.55 years and SD = 0.89 years). Involvement in bullying and social cohesion was assessed pre- and post-intervention using student peer reports. Teachers of SKILS classrooms formed SKILS teams of five teachers (N = 25; 60% male; Mage-T0 = 42.45 years and SD = 12.81 years; teacher's experience: MT0 = 11.35 years and SD = 8.36 years). Teachers were interviewed post-intervention.

Findings

While SKILS had little effect on classroom bullying dynamics, it had a positive effect on student social cohesion. Teachers indicated a learning effect with regard to identifying bottlenecks within classroom dynamics and felt more competent to intervene in response to bottlenecks due to SKILS.

Originality/value

The findings suggest that teachers can successfully impact classroom social cohesion by increasing their knowledge of classroom dynamics and working in Lesson Study (LS) teams with colleagues to develop tailored interventions for these dynamics.
A study of Yemeni EFL students' perceptions on the role of learning technologies in developing creativity and autonomy
Authors: Bin-Hady Wagdi Rashad Ali , Ali Jamal Kaid Mohammed
Published: February 2024

Purpose

This study probed the impact of using learning technologies (LT) on developing Yemeni English as a foreign language (EFL) students' autonomy and creativity toward English language learning. Also, the research gauged if LT impacts learners' autonomy and creativity across gender and university-type variables.

Design/methodology/approach

The study utilized a valid and reliable questionnaire, comprising 20 close-ended items, which was administered to 109 Yemeni EFL undergraduate students.

Findings

The researchers found that LT positively impacts learners' creativity and autonomy, with mean scores of 4.09 and 3.86, respectively. Furthermore, the results showed a medium correlation between creativity and autonomy with a correlation coefficient of r = 0.63 at a probability of Sig = 0.00. Likewise, the results revealed that LT impacted female learners' creativity more significantly than their male counterparts (Sig = 0.047). Nevertheless, no significant differences were found pertaining to the impact of LT on students' autonomy across public and private universities (Sig = 0.213).

Social implications

EFL teachers are advised to encourage their students' autonomy and creativity throughout their lifelong learning journey in order to adapt to the ever-changing demands of the world.

Originality/value

This study investigates the impact of learning technology on Yemeni EFL students' autonomy and creativity.
The evolution of positive allometry and exaggerated traits in a diverse beetle clade
Authors: Painting Christina J. , Symonds Matthew R. E. , Holwell Gregory I.
Published: February 2024

Understanding variation in trait allometry and the drivers of variation in sexually selected traits is a major theme in evolutionary biology. The static allometries of sexually selected traits are often positive due to disproportional investment by large individuals into trait size. Comparative studies of weapon allometry are rare, and typically focus on variation along a single dimension (e.g. length), despite weapons often diverging dramatically in shape. Furthermore, studies predominantly focus on groups where weapons have evolved as novel structures (e.g. horns), despite most weapons arising from modifications of existing structures.

We test the hypothesis that sexual selection drives variation in static allometry using a phylogenetic comparative approach with 59 brentine weevil species showing remarkable variation in trait exaggeration and sexual size dimorphism (SSD).

Contrasting two dimensions of head size exaggeration (a sexually selected trait) and elytron length (a nonsexual trait), positive static allometry was common across both measures of male head size, but not females, and there was positive covariance between male head static allometry and SSD across species. Positive static allometry for male elytron length was less common, but did show positive covariance with SSD, possibly due to the function of wings as compensatory structures for bearing large weapons.

Our findings support the hypothesis that sexual selection drives the evolution of allometries both within and among species, and that the modification of existing structures to be used as weapons does not limit the potential for positive static allometry.

Read the free Plain Language Summary for this article on the Journal blog.
Ant bite artifacts in a case of hanging
Authors: Pulagura Siva Sai Kumar , Jadav Devendra , Meshram Vikas P. , Shekhawat Raghvendra Singh , Kanchan Tanuj
Published: February 2024

Artifacts produced by postmortem animal scavenging are commonly encountered at autopsy. Knowledge of the pattern of artifacts produced by postmortem animal scavenging is essential for the correct interpretation of the autopsy finding. In household deaths, such artifacts are usually caused by domestic animals and by small insects such as flies, ants, beetles, etc. Ants are one of the early scavengers which feed on the dead bodies. The artifacts produced by the postmortem ant activity are usually superficial and non‐bleeding type. Rarely, in the congested body regions and areas of marked hypostasis, postmortem bleeding artifacts due to ant bites are possible. In the reported case of hanging, such postmortem bleeding artifacts were present over both the legs, predominantly over the left leg. Typical ant bite lesions in the form of superficial excoriations were also present over the peri‐ligature area, over and around both nipples and over the lower part of the abdomen. Morphologically, postmortem bleeding artifacts produced by ant bites exhibit four patterns: droplet pattern, stripe pattern, pool pattern, and mixed pattern. In this case, a mixed pattern (droplet pattern and stripe pattern) of postmortem bleeding artifacts was observed. The presence of postmortem bleeding artifacts over the lower limbs was attributed to the pooling of the blood due to suspension of the body, followed by passive escape of blood due to ant bites. The possibility of such artifacts produced by ant bites should be considered when the origin of the lesion is unclear.
Application of glasses‐free augmented reality localization in precision neurosurgery and literature review
Authors: Cui Yahui , Hou Hui , Zhou Yupeng , Zhang Haipeng , Jin Liangyan
Published: February 2024

To summarize the characteristics and therapeutic effects of glasses‐free augmented reality (AR) in neurosurgery, a case series of seven patients undergoing resection of intracranial lesions at the Neurosurgery Department of Hangzhou Xixi Hospital from November 2019 to October 2021 was collected. During the surgeries, glasses‐free AR was used for multi‐angle and multi‐modal image localization. The intraoperative positioning errors of all seven patients who underwent body surface localization with glasses‐free AR, in addition to routine surgical procedures, were less than 10 mm. These findings suggest that glasses‐free AR holds great promise for precision neurosurgery.