bluuebunny/crossref_metadata_2025 huggingface dataset:
ELEVATE-TN Study. New data of acalabrutinib in first-line treatment of chronic lymphocytic leukemia. Resolution
Authors: Poddubnaya Irina V. , Al-Radi Lyubov S. , Byalik Tatyana E. , Kaplanov Kamil D. , Molostvova Valentina Z. , Nikitin Evgeniy A. , Pospelova Tatyana I. , Ptushkin Vadim V. , Samoilova Olga S. , Stadnik Elena A. , Tumyan Gayane S.
Published: April 2020

Over the past decade, we have seen a significant change in modern approaches in the first-line treatment of chronic lymphocytic leukemia (CLL). The CLL-10 study data established the FCR regimen as the treatment of choice for younger patients with limited comorbidities, while for patients older than 65 years, the BR regimen is more often considered as less toxic one. According to published data, 46% of patients with newly diagnosed CLL have comorbidities. Moreover, high-risk patients with del(17p) and/or TP53 mutation do not have response on immunochemotherapy (ICT) most often. Thus, about 1/2 of the patients cannot be treated or will not respond to standard ICT regimens. Targeted therapy with Brutons tyrosine kinase (BTK) inhibitors is an important option of the first-line treatment of patients with CLL. Acalabrutinib is a highly selective second-generation BTK inhibitor that does not inhibit EGFR, ITK or TEC targets. Acalabrutinib in combination with obinutuzumab or as monotherapy can be considered as a highly effective and safe option of the first line of CLL therapy. Based on the hight selectivity of the agent, acalabrutinib can be considered as the preferable option for patients who are not eligible for ICT, including patients with commodities, such as cardiovascular diseases or risk factors for their development.
MHK三级考试模式下预科生写作教学存在的问题及改进措施
Authors: 张 苗
Published: April 2020

本文主要对 MHK 三级考试模式下预科生写作教学存在的问题进行探究，指出具体的改进措施以及优化策略，希望能够充分提高预科生的写作能力，促进其国家通用语言文字的使用和表达能力。
提升高中女生体育课教学效果的方案研究
Authors: 何 青青
Published: April 2020

随着社会经济文化的不断变化与发展，中国的教育体制在不断的改革与创新，这使得很多新的教学方法不断出现。由于女生的身体素质不如男生，所以各大学校开始重视女生体育课程的教学质量与水平。但是在新课标改革的背景下，要想更好地提高女生体育课教学的效果，需要利用多样化的教学模式，深入了解学生个性化的需求，循序渐进、脚踏实地地开展体育课程，全面深化体育教学改革。因此，本文针对高中女生的身心特点，提出了提升高中女生体育课教学效果的有效对策。
3D风格视觉元素对平面艺术设计创新发展的影响探析
Authors: 殷 越
Published: April 2020

近年来，随着社会经济的发展，互联网信息技术也得到了迅速的发展，越来越多的新兴技术被应用到人们的日常生活当中，其中 3D 数字技术在人们的学习和工作中得到了大量运用。 3D 风格视觉元素的应用，极大地丰富了形体塑造、视觉语言以及感官效果。其创造出的作品意境突出、个性鲜明，色彩层次协调，有着很强的趣味性，与当代人们的审美趋势相契合，从而使得人们产生视觉共鸣，该视觉元素也逐渐被应用到平面设计作品当中，更是未来设计创新发展的新趋势、新方向。
Effects of various grated sago sizes, steeping periods and trunk sections on sago
starch recovery (Metroxylon spp.)
Authors: W.A. Wan Mohd Fariz , S. Rosnah , M.N. Mohd Zuhir , Azman S. , H. Noramina
Published: April 2020

The sago palm stored a native starch between the trunk fiber gap. The trunk needed to be
crushed into a fine size using a mechanical system. In general, the grated sago size affects
the extraction efficiency, which depends on sago starch that dissolved in water during an
extraction process. Therefore, the aim of this study was to determine the effect of grated
sago sizes on starch recovery at different steeping periods and trunk sections. The sago
trunks used were selected at three palm section (Top, Middle and Bottom). After the
grating process using Sago Grater, the grated sago was dried and sieved at different sizes
(2.80 mm, 2.00 mm, 1.00 mm, 0.85 mm, 0.45 mm and 0.30 mm). Furthermore, the grated
sago with different sizes was steeped in sodium metabisulphite (Na2S2O5) at different
periods (5 mins, 24 hrs, 48 hrs and 72 hrs) for starch extraction. The results showed that
the independent variables of grated size most significantly affected starch recovery
(P<0.05). A substantial amount of starch could be recovered from grated sago by reducing
the grated size at X<0.30 mm which was up to 58% of the extraction efficiency. The
increment of the steeping period from 5 mins up to 24 hrs increased the starch recovery;
however, a longer steeping period showed an insignificant difference (P>0.05).
Additionally, the trunk selection also affects the starch recovery, however, it does not
influence the extraction efficiency.
Optimising real time clinical librarian support to enhance the evidence base in radiotherapy clinical protocols
Authors: Regan Carol-Ann , Goldsworthy Simon , Pawley Jessica
Published: April 2020

Clinical teams are professionally driven to adopt the latest evidence-based care ensuring optimal outcomes for patients. There can be delays in the latest evidence reaching practice. The radiotherapy multi-professional team in partnership with Clinical Librarians developed a lean process to undertake the real-time evidence-based live update of clinical radiotherapy protocols. Principles of Quality Function Deployment were deployed to create a lean process. The process was evaluated for the percentage difference to the radiotherapy protocol parameters over two years. Satisfaction of the live update was scored from 1: Very dissatisfied to 5: Very satisfied. Since 2014, 12 protocols have been through the process. The live update resulted in 80% of differences to the clinical protocol compared to the previous two years. Among 10 respondents, a mode of 5 was scored for satisfaction. This novel approach has been successful in providing a lean process ensuring that the latest evidence reaches radiotherapy practice.
Are You Stress On Academic? Kajian Academic Workload Pada Mahasiswa yang Berperan Ganda
Authors: Faizah Faizah , Oktawiranto Randi
Published: April 2020

Mahasiswa banyak yang mengalami stress, Sebuah penelitian yang dilakukan oleh Rahim et.al (2016) mendapatkan hasil bahwa lebih dari 80% mahasiswa mengalami stres. Hal ini dapat disebabkan beban kerja yang tinggi, seperti halnya yang disampaikan oleh Kausar (2010) & Aam et.al (2017) menunjukkan bahwa ada hubungan positif antara beban kerja dan stres akademik dengan mahasiswa. Penelitian ini bertujuan untuk mengetahui peran academic workload terhadap academic stress pada mahasiswa yang berperan ganda. Subjek merupakan mahasiswa aktif di universitas yang memiliki aktifitas lain berupa bekerja part time, subjek sebanyak 130 partisipan dengan teknik accidental sampling. Pada penelitian ini menggunakan dua instrumen penelitian yaitu Scale of academic workload (a 0.859) dan scale of academic stress (a 0.888). Analisis data menggunakan analisis data regresi linier. Hasil penelitian menunjukan terdapat pengaruh positif academic workload terhadap academic stress pada mahasiswa yang berperan ganda (R = 0.237, p<0.05).
Penyesuaian Diri Ditinjau dari Religiusitas Pada Pengguna Narkoba Di BRSKP (Balai Rehabilitasi Sosial Korban Penyalahgunaan) Napza “Insyaf” Sumatera Utara
Authors: Pangaribuan Jessica Nissi , Hartini Sri , Marpaung Winida
Published: April 2020

ABSTRACT This study aims to find out relationship between religiosity and self adjustment. The Hypothesis of this study states that there is a positive correlation between religiosity and self adjustment, assuming that the higher religiosity, the higher will self adjustment and conversely the lower religiosity, the lower will self adjustment. The subjects of this study were 180 drug users in the BRSKP Insyaf. The data analyze used is product moment Correlation with SPSS 17 for Windows. The results of data analyze showed that the correlation coefficient was 0.390 with p 0.000 (p < 0.05). It shows that there is a positive relationship between religiosity and self adjustment. These results indicate that the contribution of a given variable of religiosity to self adjustment is at 15.2 percent, while the remaining 84.8 percent is influenced by othe factors not examined. From these results, it is concluded that the hypothesis stating that there is a positive correlation between religiosity and self adjustment is acceptable. Keywords: Self Adjustment, Religiosity, Drug Users  ABSTRAK Penelitian ini bertujuan untuk mengetahui hubungan antara religiusitas dengan penyesuaian diri. Hipotesis yang diajukan dalam penelitian ini adalah ada hubungan positif antara religiusitas dengan penyesuaian diri dengan asumsi semakin tinggi religiusitas, maka semakin tinggi penyesuaian diri dan sebaliknya. Subjek penelitian yang digunakan dalam penelitian ini adalah korban penyalahgunaan narkoba di BRSKP (Balai Rehabilitasi Sosial Korban Penyalahgunaan) Napza “Insyaf” Sumatera Utara sebanyak 180 orang. Analisis data yang digunakan adalah menggunakan korelasi Product Moment melalui bantuan SPSS 17 for Windows. Hasil analisis data menunjukkan koefisien korelasi sebesar 0.390 dan nilai signifikansi sebesar 0.000 (p < 0.05). Ini menunjukkan ada hubungan positif antara religiusitas dengan penyesuaian diri. Hasil penelitian ini menunjukkan bahwa sumbangan yang diberikan variabel religiusitas terhadap penyesuaian diri sebesar 15.2 persen, selebihnya 84.8 persen dipengaruhi oleh faktor lain yang tidak diteliti. Dari hasil penelitian ini dapat disimpulkan bahwa hipotesis penelitian ada hubungan positif antara religiusitas dengan penyesuaian diri dapat diterima. Kata kunci: Penyesuaian Diri, Religiusitas   , Pengguna Narkoba[1] Jessica Nissi Pangaribuan, Universitas Prima Indonesia, Email: jessicanissi31@gmail.com
Les cent cinquante pseaumes de David, mis en musique a quatre [et cinq] parties
Authors: Le Jeune Claude
Published: April 2020

Late in his life Le Jeune turned away from learned and complex styles and composed a simple, note-for-note harmonization of the Genevan Psalter. The pieces are straightforward and tuneful, and the harmonizations are more colorful than those of his predecessor Goudimel. This attractive collection is well within the capacities of professional and amateur singers or instrumentalists.
Poet, historian, theologian: Life and creative legacy of muhammad-sadyk imankuly (1870-1932)
Authors: Saﬁn A. G.
Published: April 2020

The paper under consideration, based on the Tatar-speaking pre-revolutionary sources, analyzes the life and theological heritage of one of the most prominent and prolific representatives of Tatar cadimism of the early twentieth century Muhammad-Sadyk Imankuly (1870-1932). Particular attention is paid to his seminal work «Taskһil al-byan fi tafsir alKuran» (Facilitating clarification in Quran interpretation), which comes as an example of Tatarspeaking exegetical literature reﬂecting the main points of Hanafi-Maturidi traditions.
International Economics Midterm Assignment
Authors: Ramadhanty Shafitri Arindya
Published: April 2020

An article on International Economics
Pelanggaran Hak Cipta Oleh Korporasi Ditingkat Daerah
Authors: Ame Raysara Ame , Nomansar
Published: April 2020

Hak Cipta merupakan salah satu jenis atau macam hak yang ada dalam HaKI (Hak Kekayaan Intelektual). Hak cipta ini merupakan salah satu jenis hak yang sering dilanggar karena hak cipta merupakan hak yang paling banyak ada di Indonesia. Pelanggaran hak cipta ini menarik dibahas ketika itu dilakukan oleh perusahaan atau korporasi. Menariknya lagi ketika pelanggaran tersebut dilakukan di tingkat daerah. Apakah yuridis atau hukum hak cipta tersebut juga diatur dalam suatu penetapan melalui peraturan daerah? Tentu jawaban dari pembahasan peneliti telah ada yakni bisa saja, tapi tidak terlalu penting untuk diatur karena akibat hukum dari pelanggaran hak cipta ini menjadi urusan daripada tingkat pemerintah pusat Indonesia. Selain itu yang memeriksa dan mengadili perkara ini juga bukan domain daripada pemerintah daerah tapi pemerintah pusat.
Selective neuromodulation and mutual inhibition within the CA3-CA2 system can prioritize sequences for replay
Authors: Stöber Tristan , Lehr Andrew B. , Hafting Torkel , Kumar Arvind , Fyhn Marianne
Published: April 2020

To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We show that neuromodulatory-gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.
Pandangan generasi milenial terhadap nikah muda vs skidipapap
Authors: Febiola Stefani Cindy , anggrainy maria angelina , Adventania  , Hantoro Vincentius Arkalis Ken , Situmorang Dominikus David Biondi
Published: April 2020

Pada dasarnya kehidupan manusia tidak dapat dipisahkan dengan proses interaksi dengan orang lain, karena pada dasarnya manusia adalah makluk sosial yang pastinya membutuhkan bantuan dari orang lain. Tujuan penelitian ini adalah untuk mengetahui bagaimana relasi anak zaman sekarang dalam berbuhungan dengan lawan jenisnya. Dari data yang telah disebarluaskan melalui google form dan vote Instagram, mayoritas responden menjawab berhubungan dengan lawan jenis itu adalah sex atau having sex (skidipapap), di mana pria dan wanita melakukan hubungan tubuh di luar nikah dan berpikir bahwa yang melakukan nikah muda adalah orang yang hanya ingin melakukan sexual.
Kein Digital Twin ohne digitale Durchgängigkeit
Authors: Wagner Lars
Published: April 2020

Kurzfassung

Digital Twins bieten die Möglichkeit, das Verhalten von physischen Assets – seien es Schiffe, Autos oder Fabrikanlagen – zu simulieren, sie im laufenden Betrieb zu überwachen und durch die Rückkopplung der Betriebsdaten kontinuierlich zu verbessern. Die Daten und Modelle aus der Entwicklung bilden den Kontext, in dem die Betriebsdaten korrekt interpretiert werden können. Ihre Twin-gerechte Aufbereitung und Bereitstellung ist deshalb eine wesentliche Voraussetzung für den Einsatz von Digital-Twin-Anwendungen.
INFLUÊNCIA DA ALTURA DA CÂMERA EM FOTOGRAMETRIA COMPUTADORIZADA: AMPLITUDE ARTICULAR
Authors: SILVA DE FREITAS RODRIGO , FERREIRA DA SILVA RODRIGO LUIZ , DIAS XABREGAS CASSIUS CLEY , QUEIRÓZ ROCHA IAN VINÍCIOS , CONCEIÇÃO DA SILVA WELLIGTON
Published: April 2020

O movimento humano, e suas disfunções, constituem o principal objeto de estudos da fisioterapia. Nesse sentido, compreender e analisar de forma objetiva e precisa a complexidade dos gestos motores do ser humano, trata-se de uma questão essencial que demanda o desenvolvimento de ferramentas que possibilitem alcançar um diagnóstico funcional preciso. Objetivou-se com o presente trabalho, verificar se a mudança de posição da altura da câmera fotográfica promove variação do resultado da análise de amplitude articular do cotovelo, por meio da fotogrametria computadorizada e se altura influência na análise fotogramétrica. Foram selecionados entre os acadêmicos do 4° e 5° ano do curso de Fisioterapia da UEPA, 6 examinadores. Esses examinadores se dedicaram a obter os valores angulares de ADM da articulação do cotovelo. De vários ângulos, apenas um ângulo foi levado em consideração para a análise estatística, chamado ângulo-chave, posteriormente os dados foram analisados no programa BioEstat 5.0 e SPSS 18. Através dos resultados encontrados, observou-se distribuição normal para os dados obtidos em todas as diferentes alturas da câmera fotográfica, exceto para a altura de 50cm. Notou-se também, o mesmo padrão de variância em todas as alturas testadas, demonstrando variação não-significante entre os resultados da amostra. Conclui-se, que as variações na altura da câmera fotográfica, não foram capazes de alterar significativamente o resultado final da análise por fotogrametria computadorizada. Identificou-se que a altura de 50cm influência no resultado final, pois a mesma demonstrou nesta investigação um risco de apresentar resultados inconsistentes estatisticamente (p=0.01). Desse modo, não se recomenda a utilização dessa altura de câmera fotográfica, evitando erros na interpretação das análises fotogramétricas.
PERFIL DA GESTÃO DO NEGÓCIO DOS PERSONAL TRAINERS DE CURITIBA/PR
Authors: Filho Renato Aurélio Vidal Garcia , Carvalho Wesllen Gian , Bonin Maoski Ana Paula Cabral , Tagliari Carla Cristina
Published: April 2020

O sucesso do mercado fitness e seu consequente crescimento necessita de profissionais capacitados na área da gestão com conhecimento em marketing, finanças, administração e gerenciamento. Dentre as inúmeras áreas que o profissional formado em Bacharelado em Educação Física pode atuar, o enfoque deste trabalho está no segmento de Personal Trainer (PT). Esta demanda abre uma grande oportunidade e procura pelo serviço dos PTs, onde as pessoas buscam estes com vários objetivos, como: qualidade de vida, status, preparação física, dentre outros. O crescimento no número de oportunidades de trabalho ao PT é compatível com o ascendente número de profissionais atuantes no mercado, logo “preparação” e “qualificação” são diferenciais para obter melhores retornos financeiros. Sendo assim o objetivo deste trabalho foi de apresentar o atual perfil da gestão do negócio do PT atuante em Curitiba/PR. Foi realizada uma pesquisa descritiva quantitativa, através da aplicação de um questionário com 282 participantes, dos quais apenas 262 foram credenciados para a pesquisa. As constatações principais foram que no setor de gestão de pessoas os profissionais estão preocupados em fazer atualizações e/ou cursos na área, além de buscarem fazer de alguma maneira uma avaliação de seu trabalho com seus clientes. Em relação ao marketing observou-se que os profissionais pretendem fidelizar seus clientes, porém não realizam pacotes de aderência, o que seria recomendável; além disso, se preocupam em saber o motivo da desistência de seus serviços por parte de seus clientes contudo não possuem um padrão para estipular o preço de seus serviços ficando portanto, vulnerável ao mercado. Por fim, a gestão financeira também carece de maior preocupação haja vista que poucos profissionais confeccionam planilhas de gastos, formalizam contratos com os clientes ou preocupam-se com seus planos de previdência.
INFLUÊNCIA DO GÊNERO E TIPO DE COMPETIÇÃO SOBRE PARÂMETROS DO RALLY NO VOLEIBOL
Authors: Bento Wilian Dos Santos , De Angelis Otávio Guerson Rodrigues , Silva Isaias Soares da , Oliveira Vinícius Resende de , Franco Frederico Souzalima Caldoncelli
Published: April 2020

O objetivo deste estudo foi investigar se o gênero e o tipo de competição impactam sobre os parâmetros do rally em jogos de voleibol. Investigou 17 jogos de competições escolares e recreacionais, que foram gravados em filmadora digital, sendo analisada em ecrã de notebook de 14’. Avaliou o tempo de duração do rally e seus intervalos, densidade do set, além quantificar e caracterizar os complexos e ações nos rallies. Os resultados do presente estudo mostrou que o padrão dos rallies no voleibol em competições de equipes recreacionais foi semelhante aos de equipes escolares em treinamento, porém, nos jogos recreacionais o tempo de rally, o número de ações e o % densidade do set foram maiores do que em competições com equipes escolares em treinamento, contudo, o tempo de intervalo entre rallies foi menor. Ao fator gênero não verificou alteração na maioria dos parâmetros analisados, no entanto, observou uma frequência reduzida de complexo com três toques, que pode ser justificado pelo padrão de jogo do voleibol feminino. Também identificou um alto índice de saques errados gerando ponto à equipe adversária comparada aos aces tanto para os gêneros quanto paras os tipos de competições. Adicionalmente, observou que 82,1% dos rallies ocorreram em até 11” com predominância do complexo I, o tempo médio de rally foi de 7”7 e o tempo de intervalo 2,3 vezes maior que o de sua duração, demonstrando ser suficiente para a recuperação energética do esforço despendido. Conclui-se que o gênero e as competições escolares e recreacionais pouco interferem no padrão do rally realizado durante o jogo de voleibol.
Katalog obcojęzycznych czasopism i wydawnictw zbiorowych Biblioteki Uniwersyteckiej KUL: uzupełnienia do tytułów opublikowanych: część 2: O-Ż
Authors: Nowodworski (red.) Witold
Published: April 2020

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Problem przybliżenia badaczom zasobów historycznych dotyczących Kościoła w Polsce, przechowywanych w zbiorach obcych
Authors: Librowski Stanisław
Published: April 2020

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Stanowisko duchowieństwa galicyjskiego wobec wypadków 1848 roku: (dwa mało znane pisma)
Authors: Ziółek Jan
Published: April 2020

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Kolejna praca o historiografii diecezji
Authors: Kopiec Jan
Published: April 2020

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Função Pulmonar e Força Muscular Respiratória em Pacientes Submetidas à Cirurgia Oncológica de Mama
Authors: Monteiro Abreu Ana Paula , Endres Daiane , Bortoluzzi Costa Aline , Cecagno Zanini Sheila Cristina , Ribeiro Martini Rafael , Pereira Leguisamo Camila
Published: April 2020

Introdução: Pacientes submetidas a tratamento cirúrgico para câncer de mama poderão apresentar prejuízos físicos, entre eles: alterações respiratórias, que podem acarretar em futuras complicações, e diminuição da qualidade de vida. Objetivo: Avaliar a função pulmonar e a força muscular respiratória pré e pós-operatórias em pacientes submetidas à cirurgia oncologia de mama. Método: Participaram do estudo 20 mulheres, com diagnóstico de câncer de mama, submetidas à cirurgia conservadora (quadrantectomia) ou a mastectomia, que foram avaliadas pela manovacuometria e espirometria nos pré e pós-operatórios. Resultados: Constatou-se que, no pré-operatório, a força muscular respiratória e a função pulmonar apresentaram-se diminuídas em relação aos valores previstos para cada paciente, estando a força muscular respiratória: pressão inspiratória máxima (43,14%) e pressão expiratória máxima (40,09%); e a função pulmonar: pico de fluxo expiratório (49,86%) e volume expiratório forçado no primeiro segundo (99,14%), apenas a capacidade vital forçada (125%) estava acima do previsto. Aos valores do pré-operatório comparados ao pós-operatório na força muscular respiratória, tanto a pressão inspiratória máxima (p<0,001) quanto a pressão expiratória máxima (p<0,001) apresentaram redução no pós-operatório; na função pulmonar, o volume expiratório forçado no primeiro segundo (p<0,001) e a capacidade vital forçada (p=0,001) apresentaram-se diminuídos no pós-operatório, apenas o pico de fluxo expiratório não apresentou redução significativa (p=0,108). Conclusão: Após a cirurgia, houve diminuição da força muscular respiratória e da função pulmonar. As pacientes que realizaram tratamento neoadjuvante obtiveram diminui..o da função pulmonar, nos valores de capacidade vital forçada e do volume expiratório forçado no primeiro segundo.
Inovasi Produk Olahan Kopi Sebagai Produk Unggulan Desa Guna Mendukung Program Desa Sejahtera Mandiri
Authors: Mustapita Arini Fitria
Published: April 2020

Kemajuan dan kemakmuran desa ditentukan oleh usaha penduduk desa selain tata geografinya. Desa yang memiliki banyak sumber daya alam tetapi penduduknya tidak cukup mempunyai keterampilan, Desa Jambangan merupakan salah satu desa yang terletak di wilayah Kecamatan Dampit, Kabupaten Malang. Dampit terkenal sebagai salah satu penghasil kopi di wilayah Malang selatan. Mayoritas petani desa Jambangan juga belum memiliki keterampilan, pengetahuan, dan semangat yang tinggi untuk mengembangkan usahanya. Sumber informasi yang digunakan selama proses pengabdian diperoleh dari para pelaku (actors)/informan. Teknik yang digunakan dalam memilih informan sampling adalah dengan teknik purposive sampling. Pengolahan data dilakukan selama dan setelah pengumpulan data, baik itu data di lapangan (data primer) maupun data sekunder. Data-data yang telah dikumpulkan kemudian ditabulasi secara sederhana. Setelah ditabulasi maka data-data tersebut dianalisis sesuai dengan metode analisis data yang sesuai. Berbagai macam kopi tertanam di desa Jambangan terhitung ada 20 macam kopi ditanam ditanah desa Jambangan dan yang paling terkenal adalah kopi lanang yang rasanya lebih keras dari kopi yang lain. Ada beberapa organisasi yang mewadahi para petani di desa Jambangan yaitu Badan Usaha Milik Desa (BUMDES) dan kelompok tani, dua wadah tersebut merupakan bentuk paguyuban yang ada di desa Jambangan dimana difungsikan sebagai wadah petani kopi untuk memberikan keluhan dan masukan demi kemajuan petani kopi. Di Desa Jambangan belum semua masyarakat dapat memanfaatkan teknologi dengan baik. Dengan masalah ini desa harus memberi pelatihan tentang teknologi yang sudah modern. Sehingga masyarakat Desa Jambangan mampu memanfaatkan teknologi dengan sebaik mungkin.
Penggunaan Metode Picture and Picture untuk Meningkatkan Keterampilan Berbicara (Materi Dongeng) pada Anak Sekolah Dasar
Authors: Rosmaya Elin
Published: April 2020

Abstrak.Â  Urutan keterampilan berbahasa yang diperoleh anak secara berurutan dimulai dari keterampilan menyimak, keterampilan berbicara, keterampilan membaca dan keterampilan menulis. Â Pada keterampilan berbicara ini, anak yang menggunakan bahasa daerah sebagai bahasa ibu merasa kesulitan berbicara menggunakan bahasa indonesia sebagai bahasa nasional dan bahasa negaranya. Kecanggungan dan rasa tidak percaya diri merupakan faktor utama anak daerah kesulitan berbicara di depan umum menggunakan bahasa Indonesia dengan memperhatikan faktor kebahasaan yang tepat. Hal ini juga menjadi permasalahan yang dikeluhkan guru SDN I dan SDN II Ciparay Kecamatan Leuwimunding kabupaten Majalengka. Untuk itu, penulis melakukan penelitian dengan judul â€œPenggunaan Metode Picture and picture untuk Meningkatkan Keterampilan Berbicara (Materi Dongeng) Pada Anak sekolah Dasar.â€ Tujuan penelitian ini adalah untuk mengetahui penggunaan metode picture and picture dalam meningkatkan keterampilan berbicara anak di kelas III dan untuk mengetahui keefektifan metode picture and picture dalam meningkatkan keterampilan berbicara anak.Â  Berdasarkan penelitian, diperoleh hasil bahwa siswa yang menggunakan metode picture and picture dapat dengan mudah menceritakan kembali dan mengungkapkan pesan dongeng dibandingkan dengan yang menggunakan metode snowball throwing.Â  Hal ini menunjukan bahwa metode picture and picture dapat meningkatkan kemampuan keterampilan berbicara anak SD terutama materi mengungkapkan pesan dongeng menggunakan kosakata baru dan kalimat efektif.Â Kata Kunci : Picture and picture, Keterampilan BerbicaraÂ
Factors Related to Utilization of Traditional Massage on Elderly in Case of Myalgia by Employing Theory of Anderson
Authors: Kurniawati Puspita Adie , Wibowo Rudi , Hernawati Sri
Published: April 2020

Background: The rate number of myalgia in Bondowoso District is on the fourth ranking (7.21%). Myalgia is commonly suffered and found in elderly people. Some patients of myalgia consumed painkiller for a long time. This consumption might deliver risk of side effect like to cause obstacles in erythrocyte (red blood cells) formation, gastritis, or even osteoporosis. The side effect of chemical medicine causes to most of myalgia patient need to have non-pharmacological therapy, particularly traditional massage. The utilization of traditional massage on those elderly patients which aims to resolve complaints of myalgia in District of Bondowoso is lesser than their medical visit to public health center in approximately 1.75% or about 86 clients per month. Methods: This research was conducted with a cross sectional approach and using chi-square test. The sample size this research was 110 informants and taken by purposive random sampling. Results: The results of this research were 69 informants using traditional massage. Further, informants who has as much income per month > 1,801,406 65 people (59.01%). Most informants know as much informnation abaout traditional massage are 68 people (61.08%). Most informants stated that access to traditional massage sites is easily accessible are 93 people (84.05%). Informants who stated that traditional massage facilities meet the requirements of 62 people (56.4%). The informants stated that the quality of traditional massage fulfilled the quality requirements of 65 people (59.01%). Conclusion: Overall, both the factor of probability and need have relation to the utilization of traditional massage. Moreover, the probability factor (service quality and information) has greater determinant relation to this utilization of traditional massage on elderly people in the case of myalgia in District of Bondowoso.

Keywords: traditional massage; myalgia; elderly
A Modeling of Twisted and Coiled Polymer Artificial Muscles Based on Elastic Rod Theory
Authors: Wu Chunbing , Zheng Wen
Published: April 2020

Twisted and coiled polymer (TCP) can generate large stroke and output high power density, making it a promising artificial muscle. Thermally induced muscles fabricated from nylon or other polymer fibers can be used in robotic, biomedical devices, and energy-harvesting equipment. While fibers with different shapes and materials have different optimal process parameters. Understanding mechanisms of TCP forming and the impact of process parameters is critical to explore stronger, more powerful artificial muscles. In this paper, an elastic-rod-theory-based model was established for capturing the quantitative relationship between tensile actuation and fabrication load. Further experimental results agree with model calculation and TCP muscles used in our research reaches maximum stroke of 52.6%, strain up to 9.8 MPa, and power density of 211.89 J/kg.
Dispensing Antibiotics without a Prescription for Acute Cough Associated with Common Cold at Community Pharmacies in Shenyang, Northeastern China: A Cross-Sectional Study
Authors: Shi Li , Chang Jie , Liu Xiaoxi , Zhai Panpan , Hu Shuchen , Li Pengchao , Hayat Khezar , Kabba John Alimamy , Feng Zhitong , Yang Caijun , Jiang Minghuan , Zhao Mingyue , Hu Hao , Fang Yu
Published: April 2020

The inappropriate use of antibiotics is a major health issue in China. We aimed to assess nonprescription antibiotic dispensing and assess pharmacy service practice at community pharmacies in Shenyang, northeastern China, and to compare these practices between pediatric and adult cases. A cross-sectional study was performed from March to May 2018 using the standardized client method. Two different simulated scenarios were presented at pharmacies, namely, pediatric and adult acute cough associated with a common cold. Of 150 pharmacy visits, 147 visits were completed (pediatric case: 73, adult case: 74). A total of 130 (88.4%) community pharmacies dispensed antibiotics without a prescription, with a significant difference between pediatric and adult cases (pediatric case, 79.5% versus adult case, 97.3%, p = 0.005). Symptoms were asked in most visits (pediatric case: 82.2%, adult case 82.4%). Patients’ previous treatment and history of allergies were both inquired more frequently in the pediatric cases than in the adult cases. Medication advice was provided more often in the adult cases than in pediatric cases. Antibiotics were easily obtained without a prescription in Shenyang, especially for adult patients. Adequate inquiries and counseling had not occurred in most pharmacies.
Soybean (Glycine max) Protein Hydrolysates as Sources of Peptide Bitter-Tasting Indicators: An Analysis Based on Hybrid and Fragmentomic Approaches
Authors: Iwaniak Anna , Hrynkiewicz Monika , Minkiewicz Piotr , Bucholska Justyna , Darewicz Małgorzata
Published: April 2020

The aim of this study was to analyze soybean proteins as sources of peptides likely to be bitter using fragmentomic and hybrid approaches involving in silico and in vitro studies. The bitterness of peptides (called parent peptides) was theoretically estimated based on the presence of bitter-tasting motifs, particularly those defined as bitter-tasting indicators. They were selected based on previously published multilinear stepwise regression results. Bioinformatic-assisted analyses covered the hydrolysis of five major soybean-originating protein sequences using bromelain, ficin, papain, and proteinase K. Verification of the results in experimental conditions included soy protein concentrate (SPC) hydrolysis, RP-HPLC (for monitoring the proteolysis), and identification of peptides using RP-HPLC-MS/MS. Discrepancies between in silico and in vitro results were observed when identifying parent peptide SPC hydrolysate samples. However, both analyses revealed that conglycinins were the most abundant sources of parent peptides likely to taste bitter. The compatibility percentage of the in silico and in vitro results was 3%. Nine parent peptides with the following sequences were identified in SPC hydrolysates: LSVISPK, DVLVIPLG, LIVILNG, NPFLFG, ISSTIV, PQMIIV, PFPSIL, DDFFL, and FFEITPEK (indicators are in bold). The fragmentomic idea of research might provide a supportive method for predicting the bitterness of hydrolysates. However, this statement needs to be confirmed experimentally.
Hyperoxia Alters Ultrastructure and Induces Apoptosis in Leukemia Cell Lines
Authors: De Bels David , Tillmans Frauke , Corazza Francis , Bizzarri Mariano , Germonpre Peter , Radermacher Peter , Orman Keziban Günce , Balestra Costantino
Published: April 2020

Oxygenation conditions are crucial for growth and tumor progression. Recent data suggests a decrease in cancer cell proliferation occurring after exposure to normobaric hyperoxia. Those changes are associated with fractal dimension. The purpose of this research was to study the impact of hyperoxia on apoptosis and morphology of leukemia cell lines. Two hematopoietic lymphoid cancer cell lines (a T-lymphoblastoid line, JURKAT and a B lymphoid line, CCRF-SB) were tested under conditions of normobaric hyperoxia (FiO2 > 60%, ± 18h) and compared to a standard group (FiO2 = 21%). We tested for apoptosis using a caspase-3 assay. Cell morphology was evaluated by cytospin, microphotography after coloration, and analysis by a fractal dimension calculation software. Our results showed that exposure of cell cultures to transient normobaric hyperoxia induced apoptosis (elevated caspase-3) as well as significant and precocious modifications in cell complexity, as highlighted by increased fractal dimensions in both cell lines. These features are associated with changes in structure (pycnotic nucleus and apoptosis) recorded by microscopic analysis. Such morphological alterations could be due to several molecular mechanisms and rearrangements in the cancer cell, leading to cell cycle inhibition and apoptosis as shown by caspase-3 activity. T cells seem less resistant to hyperoxia than B cells.
Ranunculus bulumei Methanol Extract Exerts Anti-Inflammatory Activity by Targeting Src/Syk in NF-κB Signaling
Authors: Hong Yo Han , Kim Ji Hye , Cho Jae Youl
Published: April 2020

(1) Background: Ranunculus bulumei is a flowering plant that belongs to the Ranunculus species. Several Ranunculus species, such as R. aquatilis and R. muricatus, have traditionally been used to treat fever and rheumatism throughout Asia, suggesting that plants belonging to the Ranunculus species may have anti-inflammatory effects. To our knowledge, the pharmacological activity of R. bulumei has not been reported. Therefore, in this study, we aim to assess the anti-inflammatory activity of a methanol extract that was derived from R. bulumei (Rb-ME) in macrophage-mediated inflammatory responses and to identify the molecular mechanism that underlies any anti-inflammatory action. (2) Methods: The anti-inflammatory efficacy of Rb-ME was evaluated while using in vitro and in vivo experiments. The RAW264.7 cells and peritoneal macrophages were stimulated by lipopolysaccharide (LPS). In addition, LPS-induced peritonitis and HCl/EtOH-triggered gastritis models were produced. A nitric oxide (NO) assay, real-time PCR, luciferase reporter gene assay, western blot analysis, plasmid overexpression strategy, and in vitro kinase assay were used to determine the molecular mechanisms and target molecules of Rb-ME. The phytochemical active ingredients of Rb-ME were also identified by high performance liquid chromatograph (HPLC). (3) Results: Rb-ME reduced the production of NO and mRNA expression of iNOS, COX-2, IL-1β, and IL-6 without cytotoxicity. The protein secretion of TNF-α and IL-6 was also decreased by Rb-ME. HPLC analysis indicates that quercetin, luteolin, and kaempferol are the main active ingredients in the anti-inflammatory efficacy of Rb-ME. Rb-ME also blocked MyD88-induced NF-κB promoter activity and nuclear translocation of NF-κB subunits (p65 and p50). Moreover, Rb-ME reduced the phosphorylation of IκBα, Akt, p85, Src, and Syk, which are NF-κB upstream signaling molecules in LPS-activated RAW264.7 cells. According to the in vitro kinase assay, Rb-ME directly inhibits Syk kinase activity. The oral administration of Rb-ME alleviated inflammatory responses and the levels of p-IκBα in mice with LPS-induced peritonitis and HCl/EtOH-induced gastritis. (4) Conclusions Rb-ME has anti-inflammatory capacity by suppressing NF-κB signaling and it has been found to target Src and Syk in the NF-κB pathway. Based on this efficacy, Rb-ME could be developed as an anti-inflammatory herbal medicine.
Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases
Authors: Il’icheva Irina A. , Polyakov Konstantin M. , Mikhailov Sergey N.
Published: April 2020

Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate. These enzymes are involved in salvage pathways of nucleoside biosynthesis. The level of these enzymes is often elevated in tumors, which can be used as a marker for cancer diagnosis. This review presents the analysis of conformations of nucleosides and their analogues in complexes with nucleoside phosphorylases of the first (NP-1) family, which includes hexameric and trimeric purine nucleoside phosphorylases (EC 2.4.2.1), hexameric and trimeric 5′-deoxy-5′-methylthioadenosine phosphorylases (EC 2.4.2.28), and uridine phosphorylases (EC 2.4.2.3). Nucleosides adopt similar conformations in complexes, with these conformations being significantly different from those of free nucleosides. In complexes, pentofuranose rings of all nucleosides are at the W region of the pseudorotation cycle that corresponds to the energy barrier to the N↔S interconversion. In most of the complexes, the orientation of the bases with respect to the ribose is in the high-syn region in the immediate vicinity of the barrier to syn ↔ anti transitions. Such conformations of nucleosides in complexes are unfavorable when compared to free nucleosides and they are stabilized by interactions with the enzyme. The sulfate (or phosphate) ion in the active site of the complexes influences the conformation of the furanose ring. The binding of nucleosides in strained conformations is a characteristic feature of the enzyme–substrate complex formation for this enzyme group.
Chitosan Nanocomplexes for the Delivery of ENaC Antisense Oligonucleotides to Airway Epithelial Cells
Authors: Kolonko A. Katharina , Bangel-Ruland Nadine , Goycoolea Francisco M. , Weber Wolf-Michael
Published: April 2020

Nanoscale drug delivery systems exhibit a broad range of applications and promising treatment possibilities for various medical conditions. Nanomedicine is of great interest, particularly for rare diseases still lacking a curative treatment such as cystic fibrosis (CF). CF is defined by a lack of Cl− secretion through the cystic fibrosis transmembrane conductance regulator (CFTR) and an increased Na+ absorption mediated by the epithelial sodium channel (ENaC). The imbalanced ion and water transport leads to pathological changes in many organs, particularly in the lung. We developed a non-viral delivery system based on the natural aminopolysaccharide chitosan (CS) for the transport of antisense oligonucleotides (ASO) against ENaC to specifically address Na+ hyperabsorption. CS–ASO electrostatic self-assembled nanocomplexes were formed at varying positive/negative (P/N) charge ratios and characterized for their physicochemical properties. Most promising nanocomplexes (P/N 90) displayed an average size of ~150 nm and a zeta potential of ~+30 mV. Successful uptake of the nanocomplexes by the human airway epithelial cell line NCI-H441 was confirmed by fluorescence microscopy. Functional Ussing chamber measurements of transfected NCI-H441 cells showed significantly decreased Na+ currents, indicating successful downregulation of ENaC. The results obtained confirm the promising characteristics of CS as a non-viral and non-toxic delivery system and demonstrate the encouraging possibility to target ENaC with ASOs to treat abnormal ion transport in CF.
Tick and Host Derived Compounds Detected in the Cement Complex Substance
Authors: Villar Margarita , Pacheco Iván , Merino Octavio , Contreras Marinela , Mateos-Hernández Lourdes , Prado Eduardo , Barros-Picanço Dina Karen , Lima-Barbero José Francisco , Artigas-Jerónimo Sara , Alberdi Pilar , Fernández de Mera Isabel G. , Estrada-Peña Agustín , Cabezas-Cruz Alejandro , de la Fuente José
Published: April 2020

Ticks are obligate hematophagous arthropods and vectors of pathogens affecting human and animal health worldwide. Cement is a complex protein polymerization substance secreted by ticks with antimicrobial properties and a possible role in host attachment, sealing the feeding lesion, facilitating feeding and pathogen transmission, and protection from host immune and inflammatory responses. The biochemical properties of tick cement during feeding have not been fully characterized. In this study, we characterized the proteome of Rhipicephalus microplus salivary glands (sialome) and cement (cementome) together with their physicochemical properties at different adult female parasitic stages. The results showed the combination of tick and host derived proteins and other biomolecules such as α-Gal in cement composition, which varied during the feeding process. We propose that these compounds may synergize in cement formation, solidification and maintenance to facilitate attachment, feeding, interference with host immune response and detachment. These results advanced our knowledge of the complex tick cement composition and suggested that tick and host derived compounds modulate cement properties throughout tick feeding.
Protective Effect of Palm Oil-Derived Tocotrienol-Rich Fraction Against Retinal Neurodegenerative Changes in Rats with Streptozotocin-Induced Diabetic Retinopathy
Authors: Sadikan Muhammad Zulfiqah , Abdul Nasir Nurul Alimah , Agarwal Renu , Mohd Ismail Nafeeza
Published: April 2020

Oxidative stress plays an important role in retinal neurodegeneration and angiogenesis associated with diabetes. In this study, we investigated the effect of the tocotrienol-rich fraction (TRF), a potent antioxidant, against diabetes-induced changes in retinal layer thickness (RLT), retinal cell count (RCC), retinal cell apoptosis, and retinal expression of vascular endothelial growth factor (VEGF) in rats. Additionally, the efficacy of TRF after administration by two different routes was compared. The diabetes was induced in Sprague-Dawley rats by intraperitoneal injection of streptozotocin. Subsequently, diabetic rats received either oral or topical treatment with vehicle or TRF. Additionally, a group of non-diabetic rats was included with either oral or topical treatment with a vehicle. After 12 weeks of the treatment period, rats were euthanized, and retinas were collected for measurement of RLT, RCC, retinal cell apoptosis, and VEGF expression. RLT and RCC in the ganglion cell layer were reduced in all diabetic groups compared to control groups (p < 0.01). However, at the end of the experimental period, oral TRF-treated rats showed a significantly greater RLT compared to topical TRF-treated rats. A similar observation was made for retinal cell apoptosis and VEGF expression. In conclusion, oral TRF supplementation protects against retinal degenerative changes and an increase in VEGF expression in rats with streptozotocin-induced diabetic retinopathy. Similar effects were not observed after topical administration of TRF.
Deciphering Master Gene Regulators and Associated Networks of Human Mesenchymal Stromal Cells
Authors: Sánchez-Luis Elena , Joaquín-García Andrea , Campos-Laborie Francisco J. , Sánchez-Guijo Fermín , De las Rivas Javier
Published: April 2020

Mesenchymal Stromal Cells (MSC) are multipotent cells characterized by self-renewal, multilineage differentiation, and immunomodulatory properties. To obtain a gene regulatory profile of human MSCs, we generated a compendium of more than two hundred cell samples with genome-wide expression data, including a homogeneous set of 93 samples of five related primary cell types: bone marrow mesenchymal stem cells (BM-MSC), hematopoietic stem cells (HSC), lymphocytes (LYM), fibroblasts (FIB), and osteoblasts (OSTB). All these samples were integrated to generate a regulatory gene network using the algorithm ARACNe (Algorithm for the Reconstruction of Accurate Cellular Networks; based on mutual information), that finds regulons (groups of target genes regulated by transcription factors) and regulators (i.e., transcription factors, TFs). Furtherly, the algorithm VIPER (Algorithm for Virtual Inference of Protein-activity by Enriched Regulon analysis) was used to inference protein activity and to identify the most significant TF regulators, which control the expression profile of the studied cells. Applying these algorithms, a footprint of candidate master regulators of BM-MSCs was defined, including the genes EPAS1, NFE2L1, SNAI2, STAB2, TEAD1, and TULP3, that presented consistent upregulation and hypomethylation in BM-MSCs. These TFs regulate the activation of the genes in the bone marrow MSC lineage and are involved in development, morphogenesis, cell differentiation, regulation of cell adhesion, and cell structure.
Fast Immobilization of Human Carbonic Anhydrase II on Ni-Based Metal-Organic Framework Nanorods with High Catalytic Performance
Authors: Jiao Mengzhao , He Jie , Sun Shanshan , Vriesekoop Frank , Yuan Qipeng , Liu Yanhui , Liang Hao
Published: April 2020

Carbonic anhydrase (CA) has received considerable attention for its ability to capture carbon dioxide efficiently. This study reports a simple strategy for immobilizing recombinant carbonic anhydrase II from human (hCA II) on Ni-based MOFs (Ni-BTC) nanorods, which was readily achieved in a one-pot immobilization of His-tagged hCA II (His-hCA II). Consequently, His-hCA II from cell lysate could obtain an activity recovery of 99% under optimal conditions. After storing for 10 days, the immobilized His-hCA II maintained 40% activity while the free enzyme lost 91% activity. Furthermore, during the hydrolysis of p-nitrophenyl acetic acid, immobilized His-hCA II exhibited excellent reusability and still retained more than 65% of the original activity after eight cycles. In addition, we also found that Ni-BTC had no fixation effect on proteins without histidine-tag. These results show that the Ni-BTC MOFs have a great potential with high efficiency for and specific binding of immobilized enzymes.
A Simple Capillary Blood Cell Flow Monitoring System using Magnetic Micro-Sensor: A Simulation Study
Authors: Jo Seonghoon , Eom Kyungsik
Published: April 2020

Since blood flow is a physiologically important parameter in determining the state of the tissue (e.g., viability and activity), various blood flow measurement techniques have been developed. However, existing blood flow measurement methods require complex equipment to generate external energy sources to be applied onto the tissue. This paper describes a magnetic method for the simple and external source-free measurement of blood flowing throughout the capillary. A microcoil located near to the capillary captures the intrinsic magnetic field produced by flowing negatively charged blood cells (e.g., red blood cells and white blood cells) to induce the electromotive force (EMF). The velocity of blood cells is estimated using the time interval between adjacent peaks and the slope of the induced EMF. The direction of blood flow can also be determined based on the frequency shift of the induced EMF. When moving the microcoil in the same direction of the blood flow, the frequency of induced EMF decreases, whereas an increased frequency is observed when moving the microcoil in the opposite direction to the blood flow. Moreover, this method could detect and distinguish streams of red blood cells and white blood cells. These results support the feasibility of a non-invasive magnetic blood flow monitoring system that does not require any external power source applied to the blood stream and thereby alleviates the complexity of conventional blood flow monitoring systems.