bluuebunny/crossref_metadata_2025 huggingface dataset:
Gamma oryzanol niosomal gel for skin cancer: formulation and optimization using quality by design (QbD) approach
Authors: Shah Harsh S. , Gotecha Ankit , Jetha Dolly , Rajput Amarjitsing , Bariya Aditi , Panchal Shital , Butani Shital
Published: December 2021

Skin cancer is fifth most diagnosed disease in human population due to ultraviolet radiation (UV) exposure. Gamma oryzanol (OZ) is a natural antioxidant, and it also has skin anti-aging properties. OZ is naturally found in rice bran oil. The main aim of the present work was to optimize OZ niosomal formulation using quality by design approach including one variable at a time and full factorial design. Niosomes were prepared by solvent injection method and characterized for size, polydispersity index, drug entrapment, and transmission electron microscopy. The optimized batch obtained at X1 [drug to span 60 molar ratio (1:5)], X2 [volume of hydration (75 mL)], and X3 [stirring speed (2500 rpm)] to Y1 [average vesicle size (196.6 nm)] and Y2 [entrapment efficiency (78.31%)] as dependent variables. The optimized OZ noisomes were formulated by niosomal gel to provide improved physicochemical stability upon topical application against UV. The niosomal gel was characterized using pH meter, viscometer, Draize test for skin irritancy, ex vivo permeation studies, and stability studies. Ex vivo permeation studies of OZ niosomal gel not only showed fourfold higher permeation but also exhibited better drug retention in dermal layers of skin as compared to OZ gel. Quality Target Product Profile of OZ niosomal formulation was generated. Risk analysis of optimized OZ gel suggested most critical quality attributes (CQAs) and critical process parameters (CPPs) to be characterized as low risk. Thus, γ-oryzanol niosomal gel for topical use can serve as a promising prophylactic treatment in skin cancer, and the developed prototype formulation can be further extended to future newly discovered drugs with similar characteristics.

Graphical abstract
Seizures and epilepsy in patients with ischaemic stroke
Authors: Zöllner Johann Philipp , Schmitt Friedhelm C. , Rosenow Felix , Kohlhase Konstantin , Seiler Alexander , Strzelczyk Adam , Stefan Hermann
Published: December 2021

Background

With the increased efficacy of stroke treatments, diagnosis and specific treatment needs of patients with post-stroke seizures (PSS) and post-stroke epilepsy have become increasingly important. PSS can complicate the diagnosis of a stroke and the treatment of stroke patients, and can worsen post-stroke morbidity. This narrative review considers current treatment guidelines, the specifics of antiseizure treatment in stroke patients as well as the state-of-the-art in clinical and imaging research of post-stroke epilepsy. Treatment of PSS needs to consider indications for antiseizure medication treatment as well as individual clinical and social factors. Furthermore, potential interactions between stroke and antiseizure treatments must be carefully considered. The relationship between acute recanalizing stroke therapy (intravenous thrombolysis and mechanical thrombectomy) and the emergence of PSS is currently the subject of an intensive discussion. In the subacute and chronic post-stroke phases, important specific interactions between necessary antiseizure and stroke treatments (anticoagulation, cardiac medication) need to be considered. Among all forms of prevention, primary prevention is currently the most intensively researched. This includes specifically the repurposing of drugs that were not originally developed for antiseizure properties, such as statins. PSS are presently the subject of extensive basic clinical research. Of specific interest are the role of post-stroke excitotoxicity and blood–brain barrier disruption for the emergence of PSS in the acute symptomatic as well as late (> 1 week after the stroke) periods. Current magnetic resonance imaging research focussing on glutamate excitotoxicity as well as diffusion-based estimation of blood–brain barrier integrity aim to elucidate the pathophysiology of seizures after stroke and the principles of epileptogenesis in structural epilepsy in general. These approaches may also reveal new imaging-based biomarkers for prediction of PSS and post-stroke epilepsy.

Conclusion

PSS require the performance of individual risk assessments, accounting for the potential effectiveness and side effects of antiseizure therapy. The use of intravenous thrombolysis and mechanical thrombectomy is not associated with an increased risk of PSS. Advances in stroke imaging may reveal biomarkers for PSS.
Prognostic significance of microRNA 17–92 cluster expression in Egyptian chronic lymphocytic leukemia patients
Authors: Khalifa M. M. , Zaki N. E. , Nazier A. A. , Moussa M. A. , Haleem R. Abdel , Rabie M. A. , Mansour A. R.
Published: December 2021

Background

Abnormal expression patterns of microRNAs (miRs) play an important role in the development and progression of malignancy. Identification of the clinical significance and prognostic value of these small molecules in chronic lymphocytic leukemia (CLL); a disease of heterogeneous biological landscape and clinical course, has always been of tremendous translational value.

Aim

To evaluate the prognostic value of microRNA17-92 cluster members in Egyptian CLL patients.

Methods

The expression levels of miR17-92 cluster members were evaluated by qRT-PCR, including miR17, miR18a, miR19a, miR19b-1, miR20a, and miR92a-1. Other investigations included serum LDH, serum β2 microglobulin (β2M), CD38 and ZAP70 expression by flow cytometry, fluorescence in situ hybridization (FISH) for 17p deletion, and imaging studies (computerized tomography (CT) scans of neck, chest, abdomen, and pelvis or PET-CT scans).

Results

Overexpression of all members of the miRNA17-92 cluster was detected in CLL patients compared to controls (p =  < 0.001 for all miRs while p = 0.01 for miR19b-1). A significant positive correlation between Hb and miR17 and a significant negative correlation between Hb and miR19b-1 were observed (p = 0.041, 0.017 respectively). A statistically significant positive correlation between miR19b-1 expression and each of the WBCs and absolute lymphocytic count (ALC) was detected (p = 0.023, 0.022 respectively). Moreover, a statistically significant relation between miR19b-1 expression and advanced Binet stages was also found (p = 0.05). Regarding miR18a, a statistically significant positive correlation with LDH level was found (p = 0.003). We also found a significant positive correlation between miR92a-1 and β2M level (p = 0.005), as well as a significant relation between miR17 and negative CD38 expression (p = 0.034). However, no significant relationships between any of studied miRNA expression levels and 17p deletion or response to treatment were observed. Patients who expressed miR19b-1 were significantly indicated to start therapy at diagnosis (p = 0.05). The overall survival of CLL patients included in our study was 90.2% after 1 year from the time of diagnosis. Patients with high expression of miR19a had better OS than those with low expression (p = 0.04).

Conclusions

Overexpression of all members of the miR17-92 cluster was detected in Egyptian CLL patients. MiR18a, miR19b-1, and miR92a-1 also have an adverse prognostic value while miR17 can be considered a good prognostic marker. High expression of miR19a is associated with better OS.
COVID-19 pandemic impact on psychotropic prescribing for adults with intellectual disability: an observational study in English specialist community services
Authors: Naqvi Danial , Perera Bhathika , Mitchell Sarah , Sheehan Rory , Shankar Rohit
Published: December 2021

Background

Coronavirus disease 2019 (COVID-19) has had a disproportionate impact on people with intellectual disability (PwID). PwID are at higher risk of mental illness and receive psychotropic prescribing ‘off licence' also, to manage distress behaviour. The lockdown and reduction of multidisciplinary face-to-face appointments had an impact on care delivery, the recourse possibly being psychotropic prescribing. It is imperative to comprehend the influence the pandemic had on psychotropic prescribing patterns to enable future planning.

Aims

The aim was to understand the impact of the pandemic by comparing psychotropic prescribing patterns during the England lockdown with the prescribing patterns before lockdown in specialist urban and rural psychiatric services for PwID.

Method

Data was collected from Cornwall (rural) and London (urban) intellectual disability services in England as a service evaluation project to rationalise psychotropic prescribing. PwID in both services open across January 2020 to January 2021 were included. Baseline patient demographics including age, gender, ethnicity, intellectual disability level and neurodevelopmental and psychological comorbidities were collected. Baseline psychotropic prescribing and subsequent % change for each psychotropic group for the two services was compared using Pearson's chi-square and z-statistic (two tailed) with significance taken at P < 0.05.

Results

The two centres London (n = 113) and Cornwall (n = 97) were largely comparable but for baseline differences in terms of presence of severe mental illness (37 v. 86, P < 0.001), challenging behaviour (44 v. 57, P < 0.05) and attention-deficit hyperactivity disorder (37 v. 3, P < 0.001). There was an overall increase in psychotropic prescribing during lockdown in urban as compared with rural settings (11% v. 2%).

Conclusions

The pandemic caused an increase in psychotropic prescribing associated with lockdown severity and urban settings. Team structures could have played a role.
Dual Templating for AFX/LEV Intergrowth Zeolite
Authors: Tsunoji Nao , Gies Hermann , Funase Natsumi , Kolb Ute , Yokoi Toshiyuki , Sadakane Masahiro , Sano Tsuneji
Published: December 2021

Zeolite composed of an intergrowth structure based on AFX and LEV framework types was successfully synthesized by dual-templating strategy using 1,1′-(1,4-butanediyl)bis(1-azonia-4-azabicyclo[2,2,2]octane) and dimethylpiperidinium hydroxides. DIFFaX simulation and 13C NMR results indicated that the AFX framework-type is the main component of the intergrowth structure. The intergrowth material obtained was characterized using XRD, SEM, 27Al and 29Si NMR, and N2 adsorption measurements.
New Serbian records of the slug Tandonia kusceri (H. Wagner, 1931) (Gastropoda: Eupulmonata: Milacidae) suggest its continuous dispersal to the north
Authors: Gojšina Vukašin Zoran
Published: December 2021

Tandonia kusceri (H. Wagner) is a terrestrial slug native to the Balkan Peninsula (S. Serbia, N. Macedonia, Bulgaria and Dobrudja region of Romania) and the European part of Turkey. In Serbia, it was known mostly from the southern regions. The northernmost locality (Palić settlement, near Subotica) reported here suggests that the slug’s distribution is nearly continuous from its native range until Slovakia. The new record was first recognised from the pictures posted on a Facebook group for insect identification in 2021. The identification was subsequently confirmed by anatomical examination. This further emphasises the importance of social media in monitoring the spread of invasive invertebrates.
Dance Rhythms Improve Motor Symptoms in Individuals with Parkinson's Disease: A Randomized Clinical Trial
Authors: Moratelli Jéssica Amaro , Alexandre Kettlyn Hames , Boing Leonessa , Swarowsky Alessandra , Corrêa Clynton Lourenço , de Guimarães Adriana Coutinho Azevedo
Published: December 2021

Background: Evidence-based practices involving dance modalities found in binary (two-beat rhythm) or quaternary (four-beat rhythm) show that dance positively influences the motor aspects of disease.
Aim: This randomized clinical trial aimed to analyze the effect of two dance
rhythm (binary and quaternary) on the balance, gait, and mobility in individuals with Parkinson's disease (PD).
Methods: Thirty-one individuals with PD were randomized into the binary group (n = 18) and the quaternary group (n = 13). Both groups participated in different dance rhythms
lasting 12 weeks, twice a week, for 45 minutes.
Results: The binary group showed a significant difference in balance (p = 0.003), freezing of gait (p = 0.007), as well as in the motor aspects of MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), with emphasis on the total
values with a score change of 3.23. In the quaternary group, significant differences were found in balance (p = 0.021) with a score change of -2.54 and in the motor aspects of the MDS-UPDRS Part III where the total values stood out with a change of 3.54.
Discussion: When comparing
the possible effects of binary and quaternary rhythms on the motor symptoms of individuals with PD, it was demonstrated that binary rhythm improved balance, freezing gait, and UPDRSIII. As for the quaternary rhythm, the benefits were in balance and the UPDRSIII.
Conclusion: The
binary and the quaternary rhythm dance protocols positively influenced the motor symptoms of individuals with PD after 12 weeks of intervention.
The genome sequence of the spectacle, Abrostola tripartita Hufnagel, 1766
Authors: Boyes Douglas , Crowley Liam , Holland Peter W.H. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: December 2021

We present a genome assembly from an individual male Abrostola tripartita (the spectacle; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 381 megabases in span. The majority of the assembly (99.99%) is scaffolded into 31 chromosomal pseudomolecules, with the Z sex chromosome assembled.
Modern Concept of Development of Audit Activity in Russia
Authors: Loseva N.
Published: December 2021

The article discusses changes in the legislation of auditing in relation to the subject of the audit, preparation and signing of an audit report, regulation of audit activities, external control of the activities of audit organizations, auditors.
Information and Analytical Support for Sustainable Development of Companies Based on IFRS
Authors: Puchkova S. , Sotneva Yu.
Published: December 2021

The article focuses on the sustainable development initiatives and sustainable development standards, which are the bases of information-analytic analysis, helping investors to understand the IFRS’ role in climate risk disclosure and other sustainable development risks.
Changing the Paradigm of the Monetary System from Centralization to Decentralization
Authors: Soltakhanov A. , Sizova D. , Sizova T. , Zaharova D.
Published: December 2021

The features of the development of the centralization of the monetary system are considered and the possibility of its decentralization as a result of the development of blockchain technologies is determined. Th e necessity of transition to a new paradigm, in which the role and signifi cance of the decentralization of the monetary system will increase, is emphasized. New technologies of money circulation are refl ected and the possibilities of integration of centralized and decentralized monetary systems are established.
Józef Muczkowski: Dyrektor Biblioteki Jagiellońskiej, historyk
Authors: Krawczyk Barbara
Published: December 2021

The purpose of the presented thesis is to show a figure of one of the directors of the Jagiellonian Library in the 19th century, a professor at the Jagiellonian University and historian – Józef Muczkowski. In the thesis, the Professor’s personal life has been presented in chronological order, as well as his achievements in the professional field and his scientific accomplishments. The thesis consists of seven chapters, each dealing with issues related to the individual stages of the Professor’s life. Special attention has been focused on the process of intellectual and scientific development of Józef Muczkowski from his birth, through youth, to the period of holding office of the director of the Jagiellonian Library, and finally up to the last days of his life. Large part of the work is devoted to changes that were implemented by the Professor during the period when he was the Jagiellonian Library director. It concerns, among others, the organisation of library collections and complete reconstruction of the library building which is located within the Collegium Maius edifice. The thesis also introduces a broad spectrum of activities undertaken by the Professor in the political field. Presentation of profiles of his loved ones and relationships that connected him with his family and other people of science constitutes important part of the work because it connects all chapters. The thesis is based largely on unpublished sources, such as manuscripts, numerous fragments of official letters and the Professor’s correspondence. Analysis and interpretation of many types of information sources, followed by their elaboration and organisation, allow to fill the “information gap” regarding the person of Józef Muczkowski. As a result, by recreating Józef Muczkowski’s professional path, the thesis also supplements the information resource of history of the Jagiellonian Library in the first half of the 19th century.
‘Knowledge makes you stronger’
Authors: Bissett Julie
Published: December 2021

Julie Bissett discusses how one dental nurse's experience of domestic abuse set her on the road to self-help – and a quest to support other victims
A fulfilling role
Authors: Woodward Kelly , Russell Marisa
Published: December 2021

Kelly Woodward and Marisa Russell explain how dental nurses can progress both inside and outside the dental surgery
Typhoid prevention in travellers: an update
Authors: Gawthrop Mary
Published: December 2021

As international travel restarts during the worldwide COVID-19 pandemic, travellers visiting certain regions remain at risk of illnesses such as typhoid and paratyphoid. Both diseases are spread by the faecal–oral route and are predominantly diseases of countries with inadequate sanitation and poor public health resources. Typhoid is endemic in South Asia and parts of South-East Asia, the Middle East, Central and South America and Africa. At-risk travellers need clear guidance on how to prevent infection and should be offered vaccination if recommended for their planned destinations.
A voz que pensa: vertentes vococêntricas do filme-ensaio
Authors: De Almeida Rafael , Caixeta Ana Paula de Aquino
Published: December 2021

Avaliando a potência designada à voz em assumir o papel de materializadora da intenção reflexiva exigida pelo filme-ensaio, o presente artigo visa ponderar seus possíveis comportamentos dentro de tal domínio. Questiona-se o que aglutina os conceitos de voz metacrítica (RASCAROLI, 2009), voz heteroglóssica (LUPTON, 2011) e voz pneumática (SIEREK, 2007) fundados em torno à voz-over ensaística. Adensamos-nos em torno a noção de que três conceitos tão distintos de uma mesma voz denunciam seu caráter metamórfico e, desse modo, materializa o desejo de pensamento em fluxo.
Narrativa imersiva em games sonoros: escuta e paisagem sonora em A Blind Legend
Authors: Lopez Debora Cristina , Alves João
Published: December 2021

Este artigo pretende refletir sobre os recursos usados para a construção de uma narrativa sonora imersiva no jogo “A Blind Legend”, desenvolvido pela empresa francesa DOWiNO. Foi realizada uma análise descritiva (TRIVIÑOS, 2008) amparada por operadores analíticos pré-definidos que pretendem amparar a busca pelo desvendamento das estratégias acústicas adotadas e identificar seus potenciais imersigos. Os resultados apontam que A Blind Legend é um jogo sonoro imersivo, que utiliza de estratégias narrativas e técnicas para criar uma ambiência sonora, potencializando novas formas de conteúdo.
A telepoética em Chiquititas (SBT): narrativa e estilo na ficção seriada infantojuvenil
Authors: Hergesel João Paulo
Published: December 2021

Enquanto a telepoética denomina o modo de criação de um produto televisual, a estrutura melodramática se sobressai na produção de ficções seriadas televisivas. Ainda que as narrativas brasileiras busquem um itinerário tramático para chamar de seu, o SBT parece privilegiar os elementos do melodrama tradicional latino-americano. Neste artigo, com o objetivo de verificar a estrutura narrativa e as marcas estilísticas em uma obra de ficção televisiva direcionada a crianças e pré-adolescentes, adotou-se Chiquititas (2013-2015) como recorte, a partir de uma metodologia que articula estudos narrativos e estilísticos.
Presença social como abordagem metodológica em estudos de comunicação política no ambiente virtual: adaptações das categorias instituídas por Rourke
Authors: Pessoni Arquimedes , Donato Rita
Published: December 2021

Este artigo aborda como a noção de presença social tem sido usada nos trabalhos de comunicação política em ambientes virtuais a partir da categorização de Rourke et. al (2001). Ao se debater o conceito de presença social e constatar a ausência de trabalhos acadêmicos com essa abordagem, resgata-se um estudo que adaptou as categorias instituídas pelos autores para identificar a presença social de políticos no Facebook no contexto de uma campanha eleitoral. A discussão indica o uso da teoria como método inovador de pesquisa, sugerindo a ampliação das categorias a partir da coleta de dados em fóruns virtuais abertos.
Jornalismo esportivo e relações de gênero: o espaço para a participação feminina
Authors: Bueno Noemi Correa , Marques José Carlos
Published: December 2021

Apesar da evolução nas conquistas feministas, ainda há segmentos androcêntricos. Para verificar essa situação no jornalismo esportivo, foram realizadas, em 2017/2018, dois tipos de pesquisa: uma que mensurou a participação de profissionais femininos e masculinos em programas esportivos da televisão aberta brasileira; e, outra que entrevistou apresentadoras desses programas. O resultado apontou uma baixa participação feminina (11,4%) e que a elas compete a apresentação, cabendo aos homens a narração e o comentário. Isso atesta que nesse campo ainda existe uma cultura androcêntrica, cujo ethos do discurso está sob domínio masculino.
Pertencer, escapar e resistir: práticas de leitura entre jovens de grupos populares
Authors: Da Silva Sandra Rúbia , De Mello Andressa Spencer
Published: December 2021

Propomos neste artigo discutir os resultados de nossa dissertação. Em nosso estudo, procuramos compreender, através de uma etnografia, os usos e práticas de leitura dos alunos de um pré-universitário popular diante das culturas digitais. Portanto, observamos a crescente associação da leitura aos smartphones e às mídias digitais e que a leitura mais ampla (realizada no contexto da internet) se mistura e complementa a leitura tradicional feita a partir dos livros impressos, gerando outras possibilidades de leitura a serem exploradas. A leitura aqui se torna um instrumento capaz de proporcionar pertencimento, resistência e escape.
Macrossubgêneros na concepção de uma gramática promocional transmidiática
Authors: Rabaiolli Janderle
Published: December 2021

O exame de textos promocionais veiculados em diferentes plataformas midiáticas apresenta um desafio peculiar: abarcar a diversidade de modelos e formatos. Diante disso, acredita-se que os pressupostos relativos aos gêneros discursivos corroboram com o objetivo do presente artigo: identificar possibilidades de configuração de uma gramática da promocionalidade televisual transmidiática, no lançamento de um programa televisivo. O objeto empírico analisado são as ações de lançamento da telenovela Império, em televisão aberta e em um portal web. Como resultado, identifica-se a possibilidade de recorrência ao macrossubgênero como unidade aglutinadora transmidiática.
As tretas políticas no Brasil e a repercussão em rede: proposta metodológica para captura e análise de discussão política online
Authors: Carreiro Rodrigo , Chagas Viktor , Magalhães Dandara , Tsai Yi Jing
Published: December 2021

Este trabalho propõe uma metodologia de análise de conjuntura, a partir de investigação sobre de que modo uma discussão política com grande volume de publicações em redes sociais se comporta em sua fase inicial. Delineamos um método de monitoramento e coleta de dados, tendo como objeto publicações no Twitter, com o intuito de capturar o momento em que determinado assunto ganha proeminência discursiva. Com base em quatro indicadores observáveis – alta relevância política, clara controvérsia, rápida irradiação e crescimento em escala de publicações relacionadas –, apresentamos análise em torno do caso da possível soltura do ex-presidente Lula, em julho de 2018.
Projeto Metrô+Música: intencionalidades, disponibilidades e embates
Authors: Albano da Silva Júlia Lúcia de Oliveira
Published: December 2021

Este trabalho aborda o projeto Metrô+Música desenvolvido pelo Metrô de São Paulo entre junho de 2018 e fevereiro de 2019. O objetivo é compreender o que a iniciativa podem nos indicar sobre a relação entre o som e as pessoas que fazem uma megacidade como São Paulo. Para a coleta de dados recorremos às reportagens publicadas em diferentes mídias e às informações do Metrô. A pesquisa bibliográfica é composta por Ferrara para a apreensão da cidade, para a abordagem sobre o som e o ouvir recorremos a Baitello e Menezes.
AGÊNCIA LUPA: FACT-CHECKING COMO MODELO DE NEGÓCIO NA INTERNET
Authors: Dourado Jacqueline Lima , Alencar Marta Thaís
Published: December 2021

Mais de 188 sites especializados em fact-checking em mais de 60 países, conforme o mais recente registro do Duke Reporters' Lab. Desse número, 52% dos verificadores fazem parte de uma organização midiática, enquanto outros integram organizações autônomas, com fins lucrativos.  Partindo disso, o presente artigo tem como objetivo analisar a mercantilização das checagens da Agência Lupa para veículos de comunicação, com base na Economia Política do Jornalismo (EPJ), a fim de promover uma reflexão acerca da apuração jornalística que vem sendo realizada por agências independentes com fins lucrativos.
Para pensar em voz alta: voz-over heteroglóssica no filme-ensaio
Authors: De Almeida Rafael , Caixeta Ana Paula de Aquino
Published: December 2021

Objetivamos concentrar nossa discussão na utilização da voz-over subjetiva em Babás (Consuelo Lins, 2010). O problema de pesquisa a que nos dedicamos questiona de que forma a voz-over apresentada no curta-metragem se relaciona com os arquivos domésticos mobilizados pelo filme, investigando as reverberações desse recurso estilístico na estética ensaística alcançada pela obra e na reflexão por ela proposta. Pretendemos realizar uma análise fílmica da obra, centrada nos procedimentos de montagem, que dê a ver a voz-over heteroglóssica arquitetada pelo filme.
O Processo de Midiatização e a Natureza Midiática da Religião
Authors: Borelli Viviane , Regiani Herivelton
Published: December 2021

A partir de proposições acerca da natureza midiática da experiência humana e sobre experiência e comunicação, buscamos ampliar a reflexão para poder se falar em uma natureza midiática da religião. Compreende-se o processo de midiatização da religião em escala temporal mais abrangente, não devendo ser tratado como um fenômeno circunscrito às sociedades modernas. Refletimos sobre o processo de secularização e as mudanças complexas na interface entre religião e mídia. Aprofundamos bases teóricas para a compreensão do especificamente comunicacional em fenômenos religiosos atuais, que se desenvolvem e são reconfigurados segundo lógicas midiáticas.
Fotojornalismo e Futebol: imagens de violência envolvendo torcedores organizados
Authors: Cajueiro  Santos Tarcyanie , Tavares Paes Lopes Felipe , Fontanari Rodrigo
Published: December 2021

A fim de contribuir para a compreensão da construção midiática da violência no futebol, este artigo descreve e interpreta os modos pelos quais os atores envolvidos num grave confronto entre torcedores organizados do Corinthians e do Palmeiras foram imageticamente construídos numa reportagem veiculada no portal G1/Globo Esporte de notícias da Rede Globo. Para realizar essa análise, embasa-se na obra de Roland Barthes. Entre outras coisas, conclui que o portal adota uma narrativa maniqueísta, que estigmatiza as torcidas organizadas e legitima o endurecimento penal, como se graves conflitos sociais pudessem ser transformados, fundamentalmente, pela força da lei. Também conclui que ele dissimula a dimensão social e política dessas torcidas.
Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san
Authors: Ha Hyekyung , Jin Seong Eun , Seo Chang-Seob , Shin Hyeun-kyoo
Published: December 2021

Objectives: Yongdamsagan-tang (YST) and Paljung-san (PJS) in traditional medicine and finasteride in modern medicine are used to treat benign prostatic hyperplasia (BPH). In recent, the use of combination herbal remedies with conventional drugs has been increasing. Therefore, we investigated the anti-inflammatory effects of these drugs to treat BPH and the influence of herbal formulas on finasteride metabolism.Methods: The inhibitory effects of the herbal formulas and finasteride on the production of inflammatory mediators and cytokines were determined in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Additionally, the influence of herbal formulas on activities of human drug metabolizing enzymes (DMEs) was assessed using human microsomal enzymes.Results: We observed that YST, PJS and finasteride inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-6 (IL-6) in RAW 264.7 cells. The half maximal inhibitory concentration (IC50) of YST on PGE2 production was calculated to be below 25 μg/mL. YST inhibited the activity of uridine diphosphateglucuronosyltransterase (UGT) 1A4 with an IC50 value of 49.35 μg/mL. The activities of cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP3A4, and UGT1A1 were inhibited by PJS (IC50 < 100 μg/mL, each). Although PJS and YST inhibited the activities of CYP3A4 and UGT1A4, respectively, these formulas may not influence the metabolism of finasteride because the IC50 values of herbal formulas on DMEs are too high to affect metabolism.Conclusions: Our results suggest that the combination of finasteride and YST or PJS might not influence their drug metabolism and that the drugs may have synergistic effects against BPH.
Assessment of genotoxicity of Ssanghwa-tang, an herbal formula, by using bacterial reverse mutation, chromosome aberration, and in vivo micronucleus tests
Authors: Jang Ji-Hye , Seo Chang-Seob , Lee Mee-Young , Shin Hyeun-Kyoo , Han Su-Cheol , Ha Hyekyung
Published: December 2021

Objectives: Ssanghwa-tang (SHT) is a traditional herbal formula comprising nine medicinal herbs, and it is used for reducing fatigue in Korea. SHT exerts various effects such as anti-inflammatory, antioxidant, and anti-aging activities, and protection against acute hepatotoxicity. However, the genotoxicity of SHT has not yet been established.Methods: Ten components were identified in SHT water extract by using high-performance liquid chromatography analysis. We assessed the genotoxicity of SHT by using bacterial reverse mutation (Ames test), chromosome aberration, and in vivo micronucleus tests.Results: The contents of paeoniflorin, glycyrrhizin, and liquiritin apioside in SHT were 15.57, 6.94, and 3.48 mg/g extract, respectively. SHT did not increase the revertant colonies of Salmonella typhimurium and Escherichia coli strains in the presence or absence of metabolic activity. Although SHT did not induce structurally abnormal chromosomes in Chinese hamster lung (CHL) cells in the presence of metabolic activity, the number of structurally aberrated chromosomes increased dose-dependently in the absence of metabolic activity. In the in vivo micronucleus test, SHT did not affect the formation of micronuclei compared with the vehicle control.Conclusions: Genotoxicity of SHT was not observed in the Ames test and in vivo micronucleus test. However, based on the results of chromosome aberration test, it can be presumed that SHT has the potential to induce genotoxicity because it induced structurally abnormal chromosomes in the absence of metabolic activity.
A survey on the impact of a pharmacovigilance practice training course for future doctors of Korean medicine on their knowledge, attitudes, and perception
Authors: Kim Mikyung , Han Chang-ho
Published: December 2021

Objectives: This study aimed to evaluate the impact of a training course on pharmacovigilance for future doctors of Korean medicine (DKM).Methods: In 2020, a pharmacovigilance training course was conducted for 57 senior students of a Korean medicine (KM) college, and its impact to the students were assessed in terms of the knowledge, attitudes, and perceptions of these students at three-time points: pre-training, post-training, and 4-6 months after the end of the training.Results: A total of 38 students completed the survey. The average score from the knowledge test increased significantly after training compared to prior to the training (5.47±2.140, 6.61±1.001, respectively, p<0.001) and was maintained until the final survey (6.61±1.220). The rate of correct answers to most of the knowledge test questions increased after the training but decreased in the final survey. In terms of attitudes, self-confidence in causality assessment (2.63±1.025, 4.58±0.826, p<0.001) and spontaneous reporting (2.08±1.050, 4.74±0.446, p<0.001) significantly increased after the training and then slightly decreased (3.92±1.171, 4.40±0.755). The perception level was high prior to the training, and this pattern was maintained throughout the study period. Students responded that pharmacovigilance education was necessary for DKM after training, and for the undergraduates of KM colleges.Conclusions: This study shows that this pharmacovigilance training course is effective for students majoring in KM but that retraining is required at least 6 months after the initial training. Further follow-up studies are needed to ensure that students actively participate in spontaneous reporting after graduation, and continuous education should be provided to graduates.
The effectiveness and safety of cupping therapy for stroke survivors: A systematic review and meta-analysis of randomized controlled trials
Authors: Kim Mikyung , Han Chang-ho
Published: December 2021

Objectives: ncluding stroke. The aim of this study was to systematically review the clinical evidence of CT for stroke.Methods: To identify randomized controlled trials (RCTs) reporting the effectiveness and/or safety of CT, seven databases including PubMed, EMBASE, and Cochrane Library were searched for articles published from January 2000 to February 2021 without language restrictions. Meta-analysis was performed using Review Manager 5.4 software and the results were presented as mean difference (MD) or standard mean difference (SMD) for continuous variables and odds ratio (OR) for diverse variables with 95% confidence intervals (CIs). Assessment of the methodological quality of the eligible trials was conducted using the Cochrane Collaboration tool for risk of bias in RCTs.Results: Twenty-two RCTs with 1653 participants were included in the final analysis. CT provided additional benefit in improving upper limb motor function (Fugl-Meyer assessment for upper limb motor function, MD 6.91, 95% CI 4.64 to 1.67, P<0.00001) and spasticity (response rate, OR 3.28, 95% CI 1.31 to 8.22, P=0.08) in stroke survivors receiving conventional medical treatment. These findings were supported with a moderate level of evidence. CT did not significantly increase the occurrence of adverse events.Conclusions: This study demonstrated the potential of CT to be beneficial in managing a variety of complications in stroke survivors. However, to compensate for the shortcomings of the existing evidence, rigorously designed large-scale RCTs are warranted in the future.
Selection of Effective Herbal Medicines for Parkinson’s Disease Based on the Text Mining of the Classical Korean Medical Literature Donguibogam
Authors: Bae Hyo Won , Lee Tae Wook , Choi Byung Tae , Shin Hwa Kyoung , Yun Young Ju
Published: December 2021

Objectives: The prevalence of Parkinson’s disease is on an upward trend along with an increase in the aging population but there is no available treatment that halts the progression of neurodegeneration. This study reports a numerical analysis on Donguibogam and suggests novel herbal drugs, which have never been researched before but found to be deemed effective in this study.Methods: Referring to 71 Korean medicine symptom terms that represent the symptoms of Parkinson’s disease, 4170 prescriptions described in Donguibogam were classified into two groups based on whether their main effects were effective for Parkinson’s disease or not. Comparing the two groups, the chi-square test was performed to select statistically significant herbs, while the t-test, Wilcoxon test, and descriptive statistics were performed to determine the appropriate dose.Results: One hundred and twenty-seven prescriptions effective for Parkinson’s disease were identified. The chi-square test determined 17 herbs that are effective for symptomatic treatment. Among the medicinal herbs, the authors suggest Osterici seu Notopterygii Radix et Rhizoma, Ephedrae Herba, Aconiti Tuber, Myrrha, Sinomeni Caulis et Rhizoma, and Aconiti Kusnezoffii Tuber as herbal candidates that have never been studied for Parkinson’s disease. Through the statistical tests, it was judged that the mean value of the dose of the entire prescription was the appropriate dose for each herb.Conclusions: Seventeen herbs were selected for Parkinson’s disease and the appropriate daily dose were calculated. Furthermore, this study presented a new process that applies a statistical method to traditional medical literature and preselecting herbs deemed effective for specific diseases.
Development of Mission and Vision of College of Korean Medicine Using the Delphi Techniques and Big-Data Analysis
Authors: Yeo Sanghee , Choi Seong Hun , Chae Su Jin
Published: December 2021

Objectives: The purpose of this study is to introduce the procedures and methods for mission and vision development at a College of Korean Medicine (CKM), which established its mission and vision using Delphi techniques and big data analysis on various members and stakeholders.Methods: A total of 754 participated in the Delphi survey. A Delphi survey was conducted with professors, students, parents, and alumni stakeholders to establish Daegu Haany University CKM’s mission and vision. The data were analyzed through content analysis and big data analysis of keywords.Results: As a result of the study, the most important keywords to be included in the mission and vision were "professionalism" and "morality." Included in the mission were the concepts of "morality" and "professionalism," which were emphasized by the four groups. All surveyed stakeholders regarded "scientific," and "global" as important themes to be included in the vision.Conclusions: The present study confirmed that there were themes commonly prioritized by all stakeholders for college mission and vision, and a difference in demand for educational goals between professors and students was also affirmed. Therefore, institutions of higher learning should develop their mission and vision by appropriately reflecting the needs of the interest groups.
Accuracy of retrieving optical properties from liquid tissue phantoms using a single integrating sphere
Authors: Vincely Vinoin Devpaul , Vishwanath Karthik
Published: December 2021

Using integrating spheres (ISs) in conjunction with the inverse adding–doubling algorithm (IAD) offers a well-established, rigorous protocol for determining optical absorption (

μ

a

) and reduced scattering (

μ
s
′

) coefficients of thin, optically homogeneous, turbid media. Here, we report the performance and use of a single IS system for experimentally retrieving optical properties in phantom media whose optical properties were well controlled. The IS system was used to measure the total reflectance and transmittance between 500 and 800 nm in liquid phantoms that were prepared to span a wide range of optical scattering and absorption coefficients. Measurements on phantoms were sequentially made using one of two broadband light sources—a halogen lamp or a supercontinuum laser. We report on the accuracy of IAD-derived optical coefficients using IS measurements made on phantoms—directly or by employing one of two previously reported correction methods. The first (sample-substitution error) correction was experimentally achieved while the second used Monte Carlo-based corrections with IAD. When experimentally calibrated reflectance and transmittance values were directly used as inputs to the IAD, mean absolute errors in recovered optical coefficients were larger than

0.4

c
m

−
1

for absorption and more than

6

c
m

−
1

for scattering across all phantoms and wavelengths measured. These errors reduced to

0.06

−

0.17

c
m

−
1

and

0.7

−

2

c
m

−
1

for

μ

a

and

μ
s
′

, respectively, with the use of corrections. Choice of light sources used, sample geometry (relative to optical coefficients), signal-to-noise of measurements, and the selection of correction methods are discussed.
Disturbance location and pattern recognition of a distributed optical fiber sensor based on dual-Michelson interferometers
Authors: Lai Xin , Yu Houdan , Ma Yixiao , Lin Rui , Song Qiuheng , Jia Bo
Published: December 2021

A distributed fiber optic sensor based on dual-Michelson interferometers for disturbance localization and pattern recognition is proposed. The system obtains the phase difference of each of the two interferometers using a passive demodulating algorithm based on a

3

×

3

coupler. Two correlation signals with disturbance position information are obtained by delaying and subtracting the phase difference signals through which the disturbance location can be obtained. This method has the same frequency response over the whole sensing path, and there is no localization blind spot. The pattern recognition method of this sensing system is to obtain the spectral signal by fast Fourier transform of the demodulated interferometer phase information and input it as a feature vector into a one-dimensional convolutional neural network to verify the correct rate of pattern recognition for four behaviors: stepping, shearing, sweeping, and shaking. The total transmission distance of the system can reach 100 km; the location errors are within

±

35

m

, and the correct rate of four pattern recognitions is higher than 97%. The sensing system has good polarization stability, which can ensure the stability of long-term operation and has a broad application prospect in long-distance perimeter security.
Lösungsorientierte Fragen im Coaching- und Psychotherapie-Gespräch – Ein gesprächslinguistischer Vergleich ihres interaktionstypspezifischen, lokalen Veränderungspotentials
Authors: Kabatnik Susanne , Graf Eva-Maria
Published: December 2021

Der Beitrag thematisiert Lösungsorientierte Fragen (LoF) in Coaching und Psychotherapie aus linguistischer Sicht. Basierend auf gesprächsanalytischen Vorarbeiten wird die Interaktionstypspezifik von Lösungsorientierten Fragen im Coaching und in der Psychotherapie komparativ (re-)analysiert und dokumentiert. Dazu werden die formalen, funktionalen, kontextuellen und Coaching-spezifischen Charakteristika Lösungsorientierter Fragen beschrieben und es wird aufgezeigt, wie LoF zur lokalen Veränderung im Coaching-Gespräch beitragen. Parallel dazu werden diese Ergebnisse mit Erkenntnissen zu Lösungsorientierten Fragen aus dem Beratungsformat Psychotherapie verglichen und die Interaktionstyp-spezifischen Gemeinsamkeiten und Unterschiede vor dem Hintergrund der jeweiligen Handlungsrationale interpretiert. Eine erste Ausdifferenzierung des Fragetyps Lösungsorientierte Fragen für das Beratungsformat Coaching wird vorgeschlagen.
The prevalence, grouping, and distribution of stressors and their association with anxiety among hospitalized patients
Authors: Palmer Patricia K. , Wehrmeyer Kathryn , Florian Marianne P. , Raison Charles , Idler Ellen , Mascaro Jennifer S.
Published: December 2021

Anxiety is prevalent among hospital inpatients and it has harmful effects on patient well-being and clinical outcomes. We aimed to characterize the sources of hospital distress and their relationship to anxiety. We conducted a cross-sectional study of inpatients (n = 271) throughout two Southeastern U.S. metropolitan hospitals. Participants completed a survey to identify which of 38 stressors they were experiencing. They also completed the State Trait Anxiety Inventory six-item scale. We evaluated the prevalence of stressors, their distribution, and crude association with anxiety. We then used multivariate logistic regression to estimate the association between stressors and clinically relevant anxiety, with and without adjusting for demographic variables. We used factor analysis to describe the interrelationships among stressors and to examine whether groups of stressors tend to be endorsed together. The following stressors were highly endorsed across all unit types: pain, being unable to sleep, feelings of frustration, being overwhelmed, and fear of the unknown. Stressors relating to isolation/meaninglessness and fear/frustration tend to be endorsed together. Stressors were more frequently endorsed by younger, female, and uninsured or Medicaid-insured patients and being female and uninsured was associated with anxiety in bivariate analysis. After controlling for the sources of distress in multivariate linear analysis, gender and insurance status no longer predicted anxiety. Feelings of isolation, lack of meaning, frustration, fear, or a loss of control were predictive. Study results suggest that multiple stressors are prevalent among hospital inpatients and relatively consistent across hospital unit and disease type. Interventions for anxiety or emotional/spiritual burden may be best targeted to stressors that are frequently endorsed or associated with anxiety, especially among young and female patients.
Cherokee film as Cherokee storytelling: Randy Redroad’s The Doe Boy (2001) as filmic Deer Woman story
Authors: Beadling Laura L.
Published: December 2021

Rather than the stereotypical nineteenth-century leathers-and-feathers warriors familiar from countless Hollywood Westerns, many Native filmmakers focus their films on contemporary Native communities. In contrast, Native filmmakers create very different representations of Native life and especially Native masculinity. Along with the foundational Smoke Signals (), Randy Redroad’s The Doe Boy (2001) was one of the first Native-created films that helped initiate a cluster of Native American films that centre on masculinity and male–male relationships. Indigenous masculinity is often a site of struggle of rejecting colonialist impositions and finding one’s own identity, and it is in part such a journey that propels Redroad’s film. The Doe Boy responds to not only Hollywood misrepresentations but also Eyre’s earlier film that established masculinity and father–son relationships as a crucial topic. The Doe Boy focuses on Hunter (James Duval), a mixed-blood Cherokee youth, who must navigate between his White father and Cherokee grandfather and their differing practices of masculinity despite his bodily vulnerability from haemophilia, a strained and sometimes violent relationship with his father and a devastating mistake during an early deer hunt. Not only is Redroad’s film a Cherokee coming-of-age film and period piece (it is set during the AIDS crisis of the 1980s), but it can also be read as a Deer Woman story, albeit a filmic and non-traditional one. Unlike Smoke Signals, which takes the road movie as its genre, The Doe Boy has its foundations in a specific tribal culture. A crucial task in undoing to previous filmic misrepresentations of Hollywood, which lacked any specificity about Native characters, is to take Native filmmakers’ cultural context into careful consideration. Redroad’s film can be seen as a Deer Woman story that depicts Hunter’s struggles as he navigates his way to a mixed-blood manhood.