bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis
Authors: Monga Jitender , Subramani Dhatchayini , Bharathan Ajay , Ghosh Jagadananda
Published: April 2020

Much of the morbidity and mortality due to prostate cancer happen because of castration-resistant prostate cancer (CRPC) which invariably develops after anti-androgenic therapy. FDA-approved enzalutamide is commonly prescribed for CRPC which works by blocking androgen receptor function. However, even after initial good response, enzalutamide-resistant prostate cancer (ERPC) develops which eventually leads to widespread metastasis. Management of ERPC is extremely difficult because available therapeutic regimen cannot effectively kill and eliminate ERPC cells. Though the mechanism behind enzalutamide-resistance is not properly understood, over-activation of c-Myc has been found to be a common event which plays an important role in the maintenance and progression of ERPC phenotype. However, direct-targeting of c-Myc poses special problem because of its non-enzymatic nature and certain amount of c-Myc activity is needed by non-cancer cells as well. Thus, c-Myc has emerged as an elusive target which needs to be managed by novel agents and strategies in a cancer-specific way. We investigated the effects of pharmacological and genetic inhibition of 5-lipoxygenase (5-Lox) on cell proliferation, apoptosis and invasive potential of enzalutamide-resistant prostate cancer cells. Transcriptional activity of c-Myc was analyzed by DNA-binding, luciferase-assays, and expression of c-Myc-target genes. We found that 5-Lox regulates c-Myc signaling in enzalutamide-resistant prostate cancer cells and inhibition of 5-Lox by Quiflapon/MK591 or shRNA interrupts oncogenic c-Myc signaling and kills ERPC cells by triggering caspase-mediated apoptosis. Interestingly, MK591 does not affect normal, non-cancer cells in the same experimental conditions. Our findings indicate that inhibition of 5-Lox may emerge as a promising new approach to effectively kill ERPC cells sparing normal cells and suggest that development of a long-term curative therapy of prostate cancer may be possible by killing and eliminating ERPC cells with suitable 5-Lox-inhibitors.
Author Correction: Uncovering miRNAs involved in crosstalk between nutrient deficiencies in Arabidopsis
Authors: Liang Gang , Ai Qin , Yu Diqiu
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Heavy reliance on plants for Romanian cave bears evidenced by amino acid nitrogen isotope analysis
Authors: Naito Yuichi I. , Meleg Ioana N. , Robu Marius , Vlaicu Marius , Drucker Dorothée G. , Wißing Christoph , Hofreiter Michael , Barlow Axel , Bocherens Hervé
Published: April 2020

Heavy reliance on plants is rare in Carnivora and mostly limited to relatively small species in subtropical settings. The feeding behaviors of extinct cave bears living during Pleistocene cold periods at middle latitudes have been intensely studied using various approaches including isotopic analyses of fossil collagen. In contrast to cave bears from all other regions in Europe, some individuals from Romania show exceptionally high δ15N values that might be indicative of meat consumption. Herbivory on plants with high δ15N values cannot be ruled out based on this method, however. Here we apply an approach using the δ15N values of individual amino acids from collagen that offsets the baseline δ15N variation among environments. The analysis yielded strong signals of reliance on plants for Romanian cave bears based on the δ15N values of glutamate and phenylalanine. These results could suggest that the high variability in bulk collagen δ15N values observed among cave bears in Romania reflects niche partitioning but in a general trophic context of herbivory.
Author Correction: An evaluation of the accuracy and speed of metagenome analysis tools
Authors: Lindgreen Stinus , Adair Karen L. , Gardner Paul P.
Published: April 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Stochastic growth pattern of untreated human glioblastomas predicts the survival time for patients
Authors: Ma Ziwei , Niu Ben , Phan Tuan Anh , Stensjøen Anne Line , Ene Chibawanye , Woodiwiss Timothy , Wang Tonghui , Maini Philip K. , Holland Eric C. , Tian Jianjun Paul
Published: April 2020

Glioblastomas are highly malignant brain tumors. Knowledge of growth rates and growth patterns is useful for understanding tumor biology and planning treatment logistics. Based on untreated human glioblastoma data collected in Trondheim, Norway, we first fit the average growth to a Gompertz curve, then find a best fitted white noise term for the growth rate variance. Combining these two fits, we obtain a new type of Gompertz diffusion dynamics, which is a stochastic differential equation (SDE). Newly collected untreated human glioblastoma data in Seattle, US, re-verify our model. Instead of growth curves predicted by deterministic models, our SDE model predicts a band with a center curve as the tumor size average and its width as the tumor size variance over time. Given the glioblastoma size in a patient, our model can predict the patient survival time with a prescribed probability. The survival time is approximately a normal random variable with simple formulas for its mean and variance in terms of tumor sizes. Our model can be applied to studies of tumor treatments. As a demonstration, we numerically investigate different protocols of surgical resection using our model and provide possible theoretical strategies.
Accounting for detection unveils the intricacy of wild boar and rabbit co-occurrence patterns in a Mediterranean landscape
Authors: Barros Ana Luísa , Curveira-Santos Gonçalo , Marques Tiago André , Santos-Reis Margarida
Published: April 2020

The patterns of species co-occurrence have long served as a primary approach to explore concepts of interspecific interaction. However, the interpretation of such patterns is difficult as they can result from several complex ecological processes, in a scale-dependent manner. Here, we aim to investigate the co-occurrence pattern between European rabbit and wild boar in an estate in Central Portugal, using two-species occupancy modelling. With this framework, we tested species interaction for occupancy and detection, but also the interdependencies between both parameters. According to our results, the wild boar and European rabbit occurred independently in the study area. However, model averaging of the detection parameters revealed a potential positive effect of wild boar’s presence on rabbit’s detection probability. Upon further analysis of the parameter interdependencies, our results suggested that failing to account for a positive effect on rabbit’s detection could lead to potentially biased interpretations of the co-occurrence pattern. Our study, in spite of preliminary, highlights the need to understand these different pathways of species interaction to avoid erroneous inferences.
Spatially-resolved quantification of proteins in triple negative breast cancers reveals differences in the immune microenvironment associated with prognosis
Authors: Stewart Rachel L. , Matynia Anna P. , Factor Rachel E. , Varley Katherine E.
Published: April 2020

Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. Recent studies have shown that MHC class II (MHCII) expression and tumor infiltrating lymphocytes are important prognostic factors in patients with TNBC, although the relative importance of lymphocyte subsets and associated protein expression is incompletely understood. NanoString Digital Spatial Profiling (DSP) allows for spatially resolved, highly multiplexed quantification of proteins in clinical samples. In this study, we sought to determine if DSP could be used to characterize expression of MHCII and other immune related proteins in tumor epithelial versus stromal compartments of patient-derived TNBCs (N = 10) using a panel of 39 markers. We confirmed that a subset of TNBCs have elevated expression of HLA-DR in tumor epithelial cells; HLA-DR expression was also significantly higher in the tumors of patients with long-term disease-free survival when compared to patients that relapsed. HLA-DR expression in the epithelial compartment was correlated with high expression of CD4 and ICOS in the stromal compartment of the same tumors. We also identified candidate protein biomarkers with significant differential expression between patients that relapsed versus those that did not. In conclusion, DSP is a powerful method that allows for quantification of proteins in the immune microenvironment of TNBCs.
Nutrient availability affects the polar lipidome of Halimione portulacoides leaves cultured in hydroponics
Authors: Custódio Marco , Maciel Elisabete , Domingues Maria Rosário , Lillebø Ana Isabel , Calado Ricardo
Published: April 2020

Halophytes are increasingly regarded as suitable extractive species and co-products for coastal Integrated Multi-Trophic Aquaculture (IMTA) and studying their lipidome is a valid means towards their economic valorization. Halimione portulacoides (L.) Aellen edible leaves are rich in functional lipids with nutraceutical and pharmaceutical relevance and the present study aimed to investigate the extent to which its lipidome remains unchanged under a range of dissolved inorganic nitrogen (N) and phosphorus (P) concentrations typical of aquaculture effluents. Lipidomics analysis, done by hydrophilic interaction liquid chromatography coupled to high resolution mass spectrometry, identified 175 lipid species in the lipid extract of leaves: 140 phospholipids (PLs) and 35 glycolipids (GLs). Plants irrigated with a saline solution with 20–100 mg DIN-N L−1 and 3–15.5 mg DIP-P L−1 under a 1-week hydraulic retention time displayed a relatively stable lipidome. At lower concentrations (6 mg DIN-N L−1 and 0.8 mg DIP-P L−1), plants exhibited less PLs and GLs per unit of leaves dry weight and the GLs fraction of the lipidome changed significantly. This study reveals the importance of analyzing the lipidomic profile of halophytes under different nutritional regimens in order to establish nutrient-limitation thresholds and assure production conditions that deliver a final product with a consistent lipid profile.
Evaluation of a five-year predicted survival model for cystic fibrosis in later time periods
Authors: Liou Theodore G. , Kartsonaki Christiana , Keogh Ruth H. , Adler Frederick R.
Published: April 2020

We evaluated a multivariable logistic regression model predicting 5-year survival derived from a 1993–1997 cohort from the United States Cystic Fibrosis (CF) Foundation Patient Registry to assess whether therapies introduced since 1993 have altered applicability in cohorts, non-overlapping in time, from 1993–1998, 1999–2004, 2005–2010 and 2011–2016. We applied Kaplan-Meier statistics to assess unadjusted survival. We tested logistic regression model discrimination using the C-index and calibration using Hosmer-Lemeshow tests to examine original model performance and guide updating as needed. Kaplan-Meier age-adjusted 5-year probability of death in the CF population decreased substantially during 1993–2016. Patients in successive cohorts were generally healthier at entry, with higher average age, weight and lung function and fewer pulmonary exacerbations annually. CF-related diabetes prevalence, however, steadily increased. Newly derived multivariable logistic regression models for 5-year survival in new cohorts had similar estimated coefficients to the originals. The original model exhibited excellent calibration and discrimination when applied to later cohorts despite improved survival and remains useful for predicting 5-year survival. All models may be used to stratify patients for new studies, and the original coefficients may be useful as a baseline to search for additional but rare events that affect survival in CF.
Intraventricular Medium B Treatment Benefits an Ischemic Stroke Rodent Model via Enhancement of Neurogenesis and Anti-apoptosis
Authors: Chen Yun-An , Tsai Yi-Chieh , Chen Yi-Dao , Liu Der-Zen , Young Tai-Horng , Tsai Li-Kai
Published: April 2020

Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B promoted proliferation and migration of cultured NSPCs onto various 3-dimentional structures. When rat cortical neurons with oxygen glucose deprivation (OGD) were co-cultured with NSPCs, medium B treatment increased neuronal viability and reduced cell apoptosis. In a rat model with transient middle cerebral artery occlusion (MCAO), post-insult intraventricular medium B treatment enhanced proliferation, migration, and neuronal differentiation of NSPCs and diminished cell apoptosis in the infarct brain. In cultured post-OGD neuronal cells and the infarct brain from MCAO rats, medium B treatment increased protein levels of Bcl-xL, Bcl-2, phospho-Akt, phospho-GSK-3β, and β-catenin and decreased the cleaved caspase-3 level, which may be associated with the effects of anti-apoptosis. Notably, intraventricular medium B treatment increased neuronal density, improved motor function and reduced infarct size in MCAO rats. In summary, medium B treatment results in less neuronal death and better functional outcome in both cellular and rodent models of ischemic stroke, probably via promotion of neurogenesis and reduction of apoptosis.
Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
Authors: Li Wen , Li Min , Wang Ting , Ma Guangzhi , Deng Yunfu , Pu Dan , Liu Zhenkun , Wu Qiang , Liu Xuejuan , Zhou Qinghua
Published: April 2020

The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The relationship between CONUT and various clinicopathological factors as well as prognosis was evaluated. The results showed that the optimal cutoff value for CONUT to predict the 5-year survival was 3 and CONUT had a higher area under the ROC curve (AUC) for 5-year disease free survival (DFS) and overall survival (OS) prediction compared with the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI). High CONUT was significantly correlated with older age, lymph node involvement, advanced T-stage, and surgery type. In the multivariate analysis, CONUT-high patients had worse DFS and OS, when compared with CONUT-low patients. In conclusion, preoperative CONUT is a useful marker for predicting long term outcomes in breast cancer patients after curative resection.
Identifying threshold responses of Australian dryland rivers to future hydroclimatic change
Authors: Larkin Z. T. , Ralph T. J. , Tooth S. , Fryirs K. A. , Carthey A. J. R.
Published: April 2020

Rivers provide crucial ecosystem services in water-stressed drylands. Australian dryland rivers are geomorphologically diverse, ranging from through-going, single channels to discontinuous, multi-channelled systems, yet we have limited understanding of their sensitivity to future hydroclimatic changes. Here, we characterise for the first time the geomorphology of 29 dryland rivers with catchments across a humid to arid gradient covering >1,800,000 km2 of continental eastern and central Australia. Statistical separation of five specific dominantly alluvial river types and quantification of their present-day catchment hydroclimates enables identification of potential thresholds of change. Projected aridity increases across eastern Australia by 2070 (RCP4.5) will result in ~80% of the dryland rivers crossing a threshold from one type to another, manifesting in major geomorphological changes. Dramatic cases will see currently through-going rivers (e.g. Murrumbidgee, Macintyre) experience step changes towards greater discontinuity, characterised by pronounced downstream declines in channel size and local termination. Expanding our approach to include other river styles (e.g. mixed bedrock-alluvial) would allow similar analyses of dryland rivers globally where hydroclimate is an important driver of change. Early identification of dryland river responses to future hydroclimatic change has far-reaching implications for the ~2 billion people that live in drylands and rely on riverine ecosystem services.
The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation
Authors: Sun Honghong , Lin Mei , Zamani Ali , Goldsmith Jason R. , Boggs Amanda E. , Li Mingyue , Lee Chin-Nien , Chen Xu , Li Xinyuan , Li Ting , Dorrity Brigid L. , Li Ning , Lou Yunwei , Shi Songlin , Wang Wei , Chen Youhai H.
Published: April 2020

Lymphocytes are some of the most motile cells of vertebrates, constantly navigating through various organ systems. Their specific positioning in the body is delicately controlled by site-specific directional cues such as chemokines. While it has long been suspected that an intrinsic molecular pilot, akin to a ship’s pilot, guides lymphocyte navigation, the nature of this pilot is unknown. Here we show that the TIPE (TNF-α-induced protein 8-like) family of proteins pilot lymphocytes by steering them toward chemokines. TIPE proteins are carriers of lipid second messengers. They mediate chemokine-induced local generation of phosphoinositide second messengers, but inhibit global activation of the small GTPase Rac. TIPE-deficient T lymphocytes are completely pilot-less: they are unable to migrate toward chemokines despite their normal ability to move randomly. As a consequence, TIPE-deficient mice have a marked defect in positioning their T lymphocytes to various tissues, both at the steady-state and during inflammation. Thus, TIPE proteins pilot lymphocytes during migration and may be targeted for the treatment of lymphocyte-related disorders.
Mesenchymal-endothelial transition-derived cells as a potential new regulatory target for cardiac hypertrophy
Authors: Dong Wenyan , Li Ruiqi , Yang Haili , Lu Yan , Zhou Longhai , Sun Lei , Wang Dianliang , Duan Jinzhu
Published: April 2020

The role of Mesenchymal-endothelial transition (MEndoT) in cardiac hypertrophy is unclear. To determine the difference between MEndoT-derived and coronary endothelial cells is essential for understanding the revascularizing strategy in cardiac repair. Using lineage tracing we demonstrated that MEndoT-derived cells exhibit highly heterogeneous which were characterized with highly expression of endothelial markers such as vascular endothelial cadherin(VECAD) and occludin but low expression of Tek receptor tyrosine kinase(Tek), isolectin B4, endothelial nitric oxide synthase(eNOS), von Willebrand factor(vWF), and CD31 after cardiac hypertrophy. RNA-sequencing showed altered expression of fibroblast lineage commitment genes in fibroblasts undergoing MEndoT. Compared with fibroblasts, the expression of p53 and most endothelial lineage commitment genes were upregulated in MEndoT-derived cells; however, the further analysis indicated that MEndoT-derived cells may represent an endothelial-like cell sub-population. Loss and gain function study demonstrated that MEndoT-derived cells are substantial sources of neovascularization, which can be manipulated to attenuate cardiac hypertrophy and preserve cardiac function by improving the expression of endothelial markers in MEndoT-derived cells. Moreover, fibroblasts undergoing MEndoT showed significantly upregulated anti-hypertrophic factors and downregulated pro-hypertrophic factors. Therefore MEndoT-derived cells are an endothelial-like cell population that can be regulated to treat cardiac hypertrophy by improving neovascularization and altering the paracrine effect of fibroblasts.
Normative data and associated factors of hand grip strength among elderly individuals: The Yilan Study, Taiwan
Authors: Pan Po-Jung , Lin Ching-Heng , Yang Nan-Ping , Chen Hsi-Chung , Tsao Hsuan-Ming , Chou Pesus , Hsu Nai-Wei
Published: April 2020

Weak grip strength is associated with subsequent mortality in elderly populations. The normative data and associated factors of HGS in community-dwelling elderly Taiwanese populations require further evaluation. From February 2012 until the end of 2016, all residents of Yilan City, Taiwan aged 65 years or older were randomly selected for a population-based community health survey. A total of 2,470 older adults were enrolled in this study. The relationships between HGS and various anthropometric and sociodemographic correlates were examined. The results showed that HGS was higher in men than in women. The mean HGS exhibited a decreasing trend with advanced age in both men and women. HGS was significantly associated with height, weight, and exercise habits. The physical as well as the mental component summary measures of health-related quality of life (HRQoL) were positively associated with HGS. After HRQoL was integrated into the regression model, female sex, age, waist circumference, and diabetes mellitus were significantly negatively associated with HGS. In conclusion, HGS significantly decreased with advanced age. among community-dwelling Taiwanese elderly people, Various factors had different effects on HGS.
Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes
Authors: Perrino Peter A. , Talbot Lidiya , Kirkland Rose , Hill Amanda , Rendall Amanda R. , Mountford Hayley S. , Taylor Jenny ,   WGS500 Consortium, Buscarello Alexzandrea N. , Lahiri Nayana , Saggar Anand , Fitch R. Holly , Newbury Dianne F.
Published: April 2020

Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing, auditory processing and language development. We employ whole genome sequencing in a discovery family to target association and gene x environment interaction analyses in two large population cohorts; the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK10K. These investigations indicate that USH2A variants are associated with altered low-frequency sound perception which, in turn, increases the risk of developmental language disorder. We further show that Ush2a heterozygote mice have low-level hearing impairments, persistent higher-order acoustic processing deficits and altered vocalizations. These findings provide new insights into the complexity of genetic mechanisms serving language development and disorders and the relationships between developmental auditory and neural systems.
Phase-based coordination of hippocampal and neocortical oscillations during human sleep
Authors: Cox Roy , Rüber Theodor , Staresina Bernhard P. , Fell Juergen
Published: April 2020

During sleep, new memories undergo a gradual transfer from hippocampal (HPC) to neocortical (NC) sites. Precisely timed neural oscillations are thought to mediate this sleep-dependent memory consolidation, but exactly how sleep oscillations instantiate the HPC-NC dialog remains elusive. Employing overnight invasive electroencephalography in ten neurosurgical patients, we identified three broad classes of phase-based communication between HPC and lateral temporal NC. First, we observed interregional phase synchrony for non-rapid eye movement (NREM) spindles, and N2 and rapid eye movement (REM) theta activity. Second, we found asymmetrical N3 cross-frequency phase-amplitude coupling between HPC slow oscillations (SOs) and NC activity spanning the delta to high-gamma/ripple bands, but not in the opposite direction. Lastly, N2 theta and NREM spindle synchrony were themselves modulated by HPC SOs. These forms of interregional communication emphasize the role of HPC SOs in the HPC-NC dialog, and may offer a physiological basis for the sleep-dependent reorganization of mnemonic content.
Correction: Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease
Authors: Seddon Angela B. , Napier Bruce , Lindsay Ian , Lamrini Samir , Moselund Peter M. , Stone Nicholas , Bang Ole , Farries Mark
Published: April 2020

Correction for ‘Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease’ by Angela B. Seddon et al., Analyst, 2018, 143, 5874–5887.
Direct synthesis of novel quinoxaline derivatives via palladium-catalyzed reductive annulation of catechols and nitroarylamines
Authors: Xie Feng , Li Yibiao , Chen Xiuwen , Chen Lu , Zhu Zhongzhi , Li Bin , Huang Yubing , Zhang Kun , Zhang Min
Published: April 2020

A palladium-catalyzed new hydrogenative annulation reaction of catechols and nitroarylamines, allowing straightforward access to two classes of novel quinoxaline derivatives, has been demonstrated.
DFT insights into electrocatalytic CO2 reduction to methanol on α-Fe2O3(0001) surfaces
Authors: Kumar Nandha , Seriani Nicola , Gebauer Ralph
Published: April 2020

Electrocatalytic reduction of CO2 to manufacture fuels and other useful chemicals is one of the appealing methods to reuse CO2.
Coordinated behaviors of artificial micro/nanomachines: from mutual interactions to interactions with the environment
Authors: Wang Hong , Pumera Martin
Published: April 2020

The interactions leading to coordinated behaviors of artificial micro/nanomachines are reviewed.
A highly selective multi-responsive fluorescence sensor for Zn2+ based on a diarylethene with a 4,6-dimethylpyrimidine unit
Authors: Wu Xiaoxiao , Zhang Zhihui , Liu Hongliang , Pu Shouzhi
Published: April 2020

A novel multi-responsive fluorescence sensor based on a diarylethene derivative with a 4,6-dimethylpyrimidine unit was developed for Zn2+ detection.
Colorimetric detection of serum doxycycline withd-histidine-functionalized gold nanoclusters as nanozymes
Authors: Song Yuying , Qiao Juan , Liu Wei , Qi Li
Published: April 2020

An assay for selective detection of DC was developed due to the nanozymatic activity ofd-His@AuNCs inhibited by Cu2+and restored by DC.
Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides
Authors: Velázquez Marta , Alberca Saúl , Iglesias-Sigüenza Javier , Fernández Rosario , Lassaletta José M. , Monge David
Published: April 2020

Asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones affords α-aryl α-hydrazino esters/amides, key building blocks en route to artificial peptides.
Electron–phonon coupling mechanisms of broadband near-infrared emissions from Cr3+ in the Ca3Sc2Si3O12 garnet
Authors: Jia Zhenwei , Yuan Chenxu , Li Ruiyang , Sun Peng , Dong Rui , Liu Yongfu , Wang Lei , Jiang Haochuan , Jiang Jun
Published: April 2020

The electron–phonon coupling effect resulting in broad NIR emission in Ca3Sc2Si3O12:Cr3+ is revealed for the first time.
Computational insight into the halogen bonded self-assembly of hexa-coordinated metalloporphyrins
Authors: Rani Jyoti , Grover Vratta , Dhamija Swati , Titi Hatem M. , Patra Ranjan
Published: April 2020

A direct influence of porphyrin's ring current on the sigma-hole potential of halogen atoms at the axial position of metalloporphyrins during halogen bonded self-assembly is determined in this study.
Different submicellar solubilization mechanisms revealed by 1H NMR and 2D diffusion ordered spectroscopy (DOSY)
Authors: Wu Mengjian , Wu Zhaoxia , Ding Shangwu , Chen Zhong , Cui Xiaohong
Published: April 2020

Different submicellar solubilization mechanisms of two systems, Triton X-100/tetradecane and sodium dodecyl sulfate (SDS)/butyl methacrylate, are revealed on the molecular scale by 1H NMR spectroscopy and 2D diffusion ordered spectroscopy (DOSY).
Salt parameterization can drastically affect the results from classical atomistic simulations of water desalination by MoS2 nanopores
Authors: Abal João P. K. , Bordin José Rafael , Barbosa Marcia C.
Published: April 2020

In this paper we show how distinct water and ion models affect the simulation of water purification using MoS2 nanopores.
Appraising spin-state energetics in transition metal complexes using double-hybrid models: accountability of SOS0-PBESCAN0-2(a) as a promising paradigm
Authors: Alipour Mojtaba , Izadkhast Tahereh
Published: April 2020

Through a comprehensive survey, reliable double-hybrid models have been validated and proposed for spin-state energetics in transition metal complexes.
DFT study on Ag loaded 2H-MoS2for understanding the mechanism of improved photocatalytic reduction of CO2
Authors: Ouyang Tianwei , Fan Wenyuan , Guo Jiaqing , Zheng Yinan , Yin Xiaohong , Shen Yongli
Published: April 2020

DFT study on Ag loaded 2H-MoS2for mechanism of improved photocatalytic reduction of CO2.
Discovery of stable and intrinsic antiferromagnetic iron oxyhalide monolayers
Authors: Wang Shiyao , Wang Junjie , Khazaei Mohammad
Published: April 2020

It is predicted that 2-D FeOX (X = F, Cl, Br, I) are anti-ferromagnetic Mott semiconductors with good structural stabilities, relative high Néel temperature, and large magnetic anisotropy. These materials are promising for building spintronic devices.
Enhancement of HER kinetics with RhNiFe for high-rate water electrolysis
Authors: Karthick Kannimuthu , Mansoor Basha Abdul Bashith , Sivakumaran Abinaya , Kundu Subrata
Published: April 2020

The NiFeCHH is best for OER and poor for HER which by introducing Rh, showed total water splitting in KOH. It requires an ultra-low overpotential of just 36 mV at 50 mA cm−2for HERs and 286 mV at 50 mA cm−2for TWS.
Tracking copper, chlorine, and occupancy in a new, multi-story, institutional green building
Authors: Richard Rain , Hamilton Kerry A. , Westerhoff Paul , Boyer Treavor H.
Published: April 2020

Water quality deterioration in buildings poses risks to human health and infrastructure.
Recent progress on phenotype-based discovery of dengue inhibitors
Authors: Yokokawa Fumiaki
Published: April 2020

The review presents the discovery of new dengue inhibitors by a phenotype-based approach.
Toward novel sulphur-containing derivatives of tetraazacyclododecane: synthesis, acid–base properties, spectroscopic characterization, DFT calculations, and cadmium(ii) complex formation in aqueous solution
Authors: Tosato Marianna , Verona Marco , Doro Riccardo , Dalla Tiezza Marco , Orian Laura , Andrighetto Alberto , Pastore Paolo , Marzaro Giovanni , Di Marco Valerio
Published: April 2020

New sulphur derivatives of cyclen, with potential complementary properties with respect to known compounds, have been synthesized and studied.
Thin metal organic layer derived Co/Co9S8/N,S co-doped carbon nanosheets synthesized by the space confinement effect of montmorillonite for oxygen electrocatalysis
Authors: Zhang Hengbo , Niu Fuquan , Li Shaoyu , Yin Yanhong , Dong Hongyu , Yue Hongyun , Cao Zhaoxia , Yang Shuting
Published: April 2020

Co/Co9S8anchored to N,S co-doped carbon nanosheets resulting T-CCSNC electrocatalysts show excellent ORR and OER catalytic activity and stability.
Mn-mediated oxidative radical cyclization of 2-(azidomethyl)phenyl isocyanides with carbazate: access to quinazoline-2-carboxylates
Authors: Yogesh Kumar Gujjenahalli Ramalingaiah , Begum Noor Shahina , Mohammed Imran Khan
Published: April 2020

Mn-TBHP mediated oxidative radical cyclization of 2-(azidomethyl)phenyl isocyanides using methyl carbazate has been described.
Imidazole diarylethene switches: an alternative to acid-gated photochromism
Authors: Xiong Kang-Tai , Li Meng-Lian , Jiang Yue , Xu Hai-Bing , Zeng Ming-Hua
Published: April 2020

Improving the photoactivity of imidazole diarylethenes by modifying their response sites in imidazole instead of appended aryl units is accomplished.
A gold–carbon dots nanoprobe for dual mode detection of ketamine HCl in soda drinks
Authors: Tantawy Mahmoud A. , Farag Mohamed A. , Yehia Ali M.
Published: April 2020

Fluorescent and color sensors for ketamine HCl determination. A dual-mode nanoprobe for the detection of a club drug in spiked beverage.
Synthesis of characteristic polyisoprenes using rationally designed iminopyridyl metal (Fe and Co) precatalysts: investigation of co-catalysts and steric influence on their catalytic activity
Authors: Lin Wenhua , Zhang Liping , Suo Hongyi , Vignesh Arumugam , Yousuf Nighat , Hao Xiang , Sun Wen-Hua
Published: April 2020

A series of iminopyridyl ligand-based iron and cobalt complexes are utilized as catalysts in isoprene polymerization, in which the microstructure of resultant polyisoprenes was investigated.
Sky-blue iridium complexes with pyrimidine ligands for highly efficient phosphorescent organic light-emitting diodes
Authors: Ma Haiyang , Liu Di , Li Jiuyan , Mei Yongqiang , Li Deli , Ding Yong , Wei Wenkui
Published: April 2020

Three sky blue heteroleptic Ir(III) complexes with emission peaks at 457–459 nm, have been developed. A maximum quantum efficiency of 21.23% with CIE coordinates of (0.15, 0.26) is realized in their PhOLEDs, representing a higher efficiencies and improved color purities than FIrpic.
DNA-directed arrangement of soft synthetic compartments and their behavior in vitro and in vivo
Authors: Liu Juan , Craciun Ioana , Belluati Andrea , Wu Dalin , Sieber Sandro , Einfalt Tomaz , Witzigmann Dominik , Chami Mohamed , Huwyler Jörg , Palivan Cornelia G.
Published: April 2020

Soft flexible DNA-linked polymersome clusters selectively interact with the cell membrane in vitro and in vivo.
Near-infrared-excited upconversion photodynamic therapy of extensively drug-resistantAcinetobacter baumanniibased on lanthanide nanoparticles
Authors: Liu Wenzhen , Zhang Yuxiang , You Wenwu , Su Jianqiang , Yu Shaohua , Dai Tao , Huang Yunmei , Chen Xueyuan , Song Xiaorong , Chen Zhuo
Published: April 2020

This work reports a novel strategy to combat extensively drug-resistantAcinetobacter baumannii viaNIR-responsive UCNPs-based PDT.
Towards large-scale graphene transfer
Authors: Qing Fangzhu , Zhang Yufeng , Niu Yuting , Stehle Richard , Chen Yuanfu , Li Xuesong
Published: April 2020

The transfer process is crucial for obtaining high-quality graphene for its large-scale industrial application.
Poly(alanine-nylon-alanine) as a bioplastic: chemoenzymatic synthesis, thermal properties and biological degradation effects
Authors: Gudeangadi Prashant G. , Uchida Kei , Tateishi Ayaka , Terada Kayo , Masunaga Hiroyasu , Tsuchiya Kousuke , Miyakawa Hitoshi , Numata Keiji
Published: April 2020

Poly(amino acids) such as polypeptides and proteins are attractive biomass-based polymers that potentially contribute to circular economy for plastic.
Binder-free preparation of ZSM-5@silica beads and their use for organic pollutant removal
Authors: He Ping , Ding Jiehua , Qin Zhengxing , Tang Lingxue , Haw Kok-Giap , Zhang Yiying , Fang Qianrong , Qiu Shilun , Valtchev Valentin
Published: April 2020

Organic structure directing agent (OSDA)- and binder-free preparation of ZSM-5@silica beads and their use for aniline removal.
Electrical stability study of polymer-based organic transistors in ambient air using an active semiconducting/insulating polyblend-based pseudo-bilayer
Authors: Lin Bo-Ren , Cheng Horng-Long , Lin Hung-Han , Wu Fu-Chiao , Lin Jia-Hui , Chou Wei-Yang , Ruan Jrjeng , Wang Yu-Wu
Published: April 2020

Polymeric transistors with unexpected nondecaying features even in ambient air are fabricated based on a P3HT/PMMA pseudo-bilayer with microphase separation morphology.
A GFP-chromophore-based C3V-symmetric tripodal receptor with selective recognition of Hg(ii), Fe(iii) and Cr(iii)
Authors: Chou Chun-Yen , Sung Robert , Chang Wei-Luen , Sung Kuangsen
Published: April 2020

A GFP-chromophore tripodal receptor with a diameter of cavity = 2.7–3.5 Å selectively captures Hg2+, Fe3+ or Cr3+ ions.
Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine scaffolds
Authors: Elattar Khaled M. , Mert Başak Doğru , Monier M. , El-Mekabaty Ahmed
Published: April 2020

The current study provides an overview of the synthetic routes, reactivity and privileged biological characteristics of bicyclic heterocycles incorporating pyrimido[1,6-a]pyrimidine and pyrimido[1,6-c]pyrimidine cores.
Applications of nano-materials in diverse dentistry regimes
Authors: Foong Loke Kok , Foroughi Mohammad Mehdi , Mirhosseini Armita Forutan , Safaei Mohadeseh , Jahani Shohreh , Mostafavi Maryam , Ebrahimpoor Nasser , Sharifi Maryam , Varma Rajender S. , Khatami Mehrdad
Published: April 2020

The present review paper provided an overall overview of various kinds, synthesis techniques, characteristics, features and uses of nanomaterials.
Sulfamic acid incorporated HKUST-1: a highly active catalyst and efficient adsorbent
Authors: Kaid Mahmoud M. , Gebreil Ahmed , El-Hakam Soheir A. , Ahmed Awad. I. , Ibrahim Amr Awad
Published: April 2020

Herein we introduce an effective approach for incorporating sulfamic acid (SA) into HKUST-1.
Catalyst Acquisition by Data Science (CADS): a web-based catalyst informatics platform for discovering catalysts
Authors: Fujima Jun , Tanaka Yuzuru , Miyazato Itsuki , Takahashi Lauren , Takahashi Keisuke
Published: April 2020

An innovative web-based integrated catalyst informatics platform, Catalyst Acquisition by Data Science (CADS), is developed for use towards the discovery and design of catalysts.
Electrodeposition of (hydro)oxides for an oxygen evolution electrode
Authors: Yan Zhenhua , Liu Huanhuan , Hao Zhimeng , Yu Meng , Chen Xiang , Chen Jun
Published: April 2020

This minireview looks at recent electrodeposition strategies for metal (hydro)oxide design and water oxidation applications, unveiling the unique properties and underlying principles of electrodeposited metal (hydro)oxides in the OER.
All-self-metered solution-coating process in ambient air for the fabrication of efficient, large-area, and semitransparent perovskite solar cells
Authors: Bae In-Gon , Park Byoungchoo
Published: April 2020

Large-area semitransparent MAPbI3 perovskite photovoltaic cells with fully self-metered horizontal-dip-coated functional layers fabricated in air.
Identification of active sites for CO2hydrogenation in Fe catalysts by first-principles microkinetic modelling
Authors: Han Seung Ju , Hwang Sun-Mi , Park Hae-Gu , Zhang Chundong , Jun Ki-Won , Kim Seok Ki
Published: April 2020

The active phase of Fe catalysts for RWGS is identified and an efficient promoter is proposed using DFT-microkinetics.
Long-lifespan lithium–metal batteries obtained using a perovskite intercalation layer to stabilize the lithium electrode
Authors: Kaisar Nahid , Singh Anupriya , Yang Po-Yu , Chen Yu-Ting , Li Shenghan , Pao Chun-Wei , Jou Shankay , Chu Chih-Wei
Published: April 2020

Because it has the highest specific capacity and lowest reduction potential among the elements, as well as a low density, lithium (Li) metal has been the most practical anode material for high energy density lithium-ion batteries.
Novel LixSiSy/Nafion as an artificial SEI film to enable dendrite-free Li metal anodes and high stability Li–S batteries
Authors: Jin Qi , Zhang Xitian , Gao Hong , Li Lu , Zhang Zhiguo
Published: April 2020

We propose an approach for Li metal anode protection by in situ growth of a LixSiSy/Nafion composite layer on the surface of the Li metal as an artificial SEI film to significantly enhance the stability of the Li metal anode.
Compact and ultrathin multi-element oxide films grown by temperature-controlled deposition and their surface-potential based transistor theoretical simulation model
Authors: Liu Jiahui , Yang Zunxian , Lin Shimin , Zheng Kang , Ye Yuliang , Ye Bingqing , Gong Zhipeng , Qiu Yinglin , Xu Lei , Guo Tailiang , Xu Sheng
Published: April 2020

Thin IMZO films were synthesized by a temperature controlled approach and applied to TFTs with good performance. The modification factor of voltage was introduced to simulate the electrical characteristics of devices.
Age Norms for Auditory-Perceptual Neurophonetic Parameters: A Prerequisite for the Assessment of Childhood Dysarthria
Authors: Schölderle Theresa , Haas Elisabet , Ziegler Wolfram
Published: April 2020

Purpose

The aim of this study was to collect auditory-perceptual data on established symptom categories of dysarthria from typically developing children between 3 and 9 years of age, for the purpose of creating age norms for dysarthria assessment.

Method

One hundred forty-four typically developing children (3;0–9;11 [years;months], 72 girls and 72 boys) participated. We used a computer-based game specifically designed for this study to elicit sentence repetitions and spontaneous speech samples. Speech recordings were analyzed using the auditory-perceptual criteria of the Bogenhausen Dysarthria Scales, a standardized German assessment tool for dysarthria in adults. The Bogenhausen Dysarthria Scales (scales and features) cover clinically relevant dimensions of speech and allow for an evaluation of well-established symptom categories of dysarthria.

Results

The typically developing children exhibited a number of speech characteristics overlapping with established symptom categories of dysarthria (e.g., breathy voice, frequent inspirations, reduced articulatory precision, decreased articulation rate). Substantial progress was observed between 3 and 9 years of age, but with different developmental trajectories across different dimensions. In several areas (e.g., respiration, voice quality), 9-year-olds still presented with salient developmental speech characteristics, while in other dimensions (e.g., prosodic modulation), features typically associated with dysarthria occurred only exceptionally, even in the 3-year-olds.

Conclusions

The acquisition of speech motor functions is a prolonged process not yet completed with 9 years. Various developmental influences (e.g., anatomic–physiological changes) shape children's speech specifically. Our findings are a first step toward establishing auditory-perceptual norms for dysarthria in children of kindergarten and elementary school age.

Supplemental Material

https://doi.org/10.23641/asha.12133380
Design of adaptive intuitionistic fuzzy controller for synchronisation of uncertain chaotic systems
Authors: Hamdy Mohamed , Helmy Salah , Magdy Mohamed
Published: April 2020

This study presents the synchronisation between two non‐linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller (AIFC). This problem is solved in the presence of external disturbances and uncertainties. Two classes of Lorenz systems have been formulated one as the master and the other as the slave. The master and slave systems have different initial conditions. Under different initial conditions, both systems diverge. This is called the butterfly effect that rules the behaviour of chaotic systems. AIFC is chosen as a different method that has not been used before to synchronise the chaotic systems. The scaling factors of the inputs and the output of the intuitionistic fuzzy controller (IFC) are tuned using the artificial bee colony (ABC) algorithm depending on a specified objective function. Then IFC stability is studied when it is applied to synchronise the Lorenz system. The simulation results achieved to assess the adequacy of the proposed control and to exhibit its dependability to synchronise the Lorenz system.
The main dynamics of sunflower research presented at the 19th International Sunflower Conference in 2016
Authors: Pilorgé Etienne , Dauguet Sylvie , Jestin Christophe , Mestries Emmanuelle
Published: April 2020

The International Sunflower Conference takes place every four years under the auspices of the ISA, International Sunflower Association. Before the 20th Conference in June 2020, a review of the proceedings of the Edirne conference, in June 2016, offers a vision of the crop and research dynamics in the world, as well as international cooperation programmes in progress or to be developed in the period 2016–2020. They are essential for the future of this crop for which demands tend to diversify. Sustained efforts have led to significant progress in genomics. The challenges posed by pests and by climatic constraints remain significant. The interest in gathering knowledge on crop models incorporating varietal parameters appears clearly, both to establish long-term adaptation strategies and to make better use of current resources.
Answer to the comments on “Confirming geomagnetic Sfe by means of a solar flare detector based on GNSS”
Authors: Curto Juan José , Juan Jose Miguel , Timoté Cristhian Camilo
Published: April 2020

Hernández-Pajares and García-Rigo have written a document criticizing our paper “Confirming geomagnetic Sfe by means of a solar flare detector based on GNSS. J Space Weather Space Clim 9: A42. https://doi.org/10.1051/swsc/2019040” (Curto et al., 2019). The main goal of our paper was to define a methodology based on GNSS measurements that is able to detect solar flares (SF) in an automatic way. This methodology was used to confirm Sfe (SF effects) detected by geomagnetism in an unsupervised manner. In their document, Hernández-Pajares and García-Rigo posed two objections related to the correctness and the novelty of the methodology used in our paper. This document is a reply to these objections and concludes that they are not relevant.
Gesundheitskompetenz und die Corona-Krise
Authors: Abel Thomas
Published: April 2020

„Wir sind eine Demokratie. Wir leben nicht von Zwang, sondern von
geteiltem Wissen und Mitwirkung“

Angela Merkel, TV-Ansprache an die Nation, 18.3.2020

Wenn es um Infektionskrankheiten geht, so waren unsere Gesundheitssysteme immer
schon auf das aktive Mittun der Bevölkerung angewiesen. Die Menschen
mussten sich auch früher schon angemessen verhalten, z. B. mit
Hygienemaßnahmen im Alltag, um Infektionsketten zu unterbrechen, um
Versorgungssysteme nicht zu überlasten oder anderweitig mithelfen,
Schlimmeres zu verhindern.
Premiere der Praxis Handreha auf der TheraPro
Authors: Laquai Sophia
Published: April 2020

Die neue Zeitschrift Praxis Handreha feierte ihren Einstand auf der Fachmesse TheraPro vom 7.–9.2.2020 in Stuttgart. Beim Kongress, der un
ter dem Motto Team works stattfand, suchten sich Ergo- und Physiotherapeuten ihre Themen aus dem interdisziplinär angelegten Programm, das auch zwei Vortragsmodule zur Handreha bot. Ein gelungener Auftakt.
Manifestation of the β-Silicon Effect in the Reactions of Unsaturated Systems Involving a 1,2-Silyl Shift
Authors: Turks Māris , Beļaunieks Rūdolfs , Puriņš Mikus
Published: April 2020

Many chemical transformations of organosilicon compounds proceed due to the capability of silyl substituents to stabilize a positive charge in its β-position. This short review provides an overview of the present understanding of the β-silicon effect and focusses on the synthetic applications of 1,2-silyl shifts resulting from non-vertical stabilization of alkylcarbenium ions and vinyl cations. The reactions of silicon containing unsaturated starting materials, alkenes, allenes, and alkynes, involving β-silyl group stabilized cationic intermediates, transition metal carbenes, or vinylidene complexes will be discussed.

1 Introduction

2 Origins of the β-Silicon Effect

3 Reactions of Allenylsilanes

4 Reactions of Alkynes

4.1 Propargylsilanes

4.2 Alkynylsilanes

5 Reactions of Alkenes

5.1 Allylsilanes

5.2 Vinylsilanes

6 Conclusions