bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between liquidity and profitability: An analysis of Indian cement companies
Authors: Gill Harsheen
Published: June 2022

The ultimate aim of working capital management is to enable a firm to maximize profits from its operations and to maintain enough liquidity at the same time. As liquidity and profitability are inversely related to each other, hence increasing profitability would tend to reduce firms’ liquidity and too much attention on liquidity would tend to affect the profitability. Though every firm tries to maximize the profitability by preserving the liquidity but, increasing profits at the cost of liquidity might cause serious trouble to the firm and this problem might lead to financial insolvency as well. Thus an effective balance between liquidity and profitability is very much required to achieve both of the objectives of every firm, i.e. liquidity and profitability. To increase profit, a firm need to forgo liquidity which might damage the firm’s goodwill, deteriorate firm’s credit standings and that might lead to forced liquidation of firm’s assets and excessive liquidity on the other hand indicates the accumulation of idle funds that don’t fetch any profits for the firm. Hence a study is very much required to understand how firms earn profit without compromising the liquidity. This study is an attempt to establish the relationship between the liquidity and profitability of top ten Indian cement companies. The data has been analyzed using Spearman's Rank Coefficient of Correlation and it is found that both liquidity and profitability is negatively correlated which confirms the theoretical viewpoint.
A study of pre-analytical errors in the clinical biochemistry laboratory of Shri Mahant Indresh Hospital, Dehradun
Authors: Ahsan Farah , Samreen Sumeera , Bansal Mamta , Narang Mandeep , Masood Tariq
Published: June 2022

The aim and objective of study was to categorize and calculate the percentage error of pre-analytical variables in the clinical biochemistry laboratory.

A Prospective study was Conducted at Central laboratory Department of Biochemistry Shri Mahant Indresh Hospital for a period of three months from December 2021 to February 2022.During this period different types of pre-analytical errors were monitored.

Out of 279,137 samples received during the study period, 152 samples were found to be unsuitable for testing, accounting 0.054% of the rejection. All the samples were rejected due to different types of pre-analytical errors that are due to haemolysis 140 (0.050%) followed by wrong sample 6 (0.0021%), Typing error 3 (0.00107%) and Wrong ID 1(0.00035%).Out of these rejection 148 samples were from IPD and 4 samples were from OPD.

Pre-analytical errors occurring in each laboratory have to be checked. In this study pre-analytical errors in IPD samples were more than OPD samples. Such errors are not inevitable and can be avoided with diligent application of quality control, continuing education and effective collection system.
Impact of whats app usage by the youths of davangere city
Authors: Chandrahasa Ramesh , Hareesh Setty A. , Das Bhagavathi
Published: June 2022

Today in rapidly moving in world, Technology is not a new concept. What’s app is an amazing application, this study revealed that what’s app is a medium of making communication simple and quicker, there-by enhancing that effective flow of information, idea sharing and connecting people easier. Present study examined that how negatively it’s impacting on youths on their life style, culture, psychological behaviour, education and routine life. This study made an attempt to assess the impact of what’s app usage by youths, with the reference of youths in Davangere region. The empirical study has been conducted upon 100 youths by using questionnaire tool to collect the lots of data relatively in shorter period of time with less cost.
An estimate of awareness skill level in financial instruments among management students
Authors: Venkat Rao G , Nagavalli P , Anjana R
Published: June 2022

The financial literacy is the requisite for development and growth of the economy. The pedagogy for the delivery of financial knowledge in Indian management schools is both with e-technology and traditional methods. The financial instrument is a contract that gives rise to a financial asset of one entity and a financial liability or equity instrument of another entity.

The awareness of financial instruments and skill to invest in these instruments is awareness skill. The study is designed to estimate the awareness skill level of financial instrument of management students'. The research design formulated for the study is descriptive with a sample of 131(10 percent of the sample) drawn randomly from students of post graduate level pursing professional management courses. The schedule with 24 items is administered and the results are analyzed with percentages and ANOVA.

The first null hypothesis of low awareness skill is accepted and other two null hypotheses are rejected. There is a significant variation of awareness skill level of financial instruments with focus on gender and specialization. The awareness skill level is confined to fixed deposits and recurring deposits.
Gold price dynamics in India: A pre-post-liberalisation comparison
Authors: Karunakaran N , Pradeep K. V.
Published: June 2022

There are considerable differences in gold price movements in India in the periods of pre-and-post globalised regimes. This is because of a change in the controlled regime in the pre-liberalised to a meticulous dilution in the post-liberalised era. Hence, the liberalised period witnessed an upward trend in price dynamics with only occasional dampening in the price cycles. The jewellery sector in India is not driven by local forces as most of the inputs are imported for production and value-added export. It is revealed that the positive impact is the result of liberalisation and related mechanisation. Gold price shows a kind of co-integration of domestic prices with the global cues. In the pre-post-dichotomy, the post-liberalisation period is more integrated with the global prices than the pre-liberalised.
Nerviosos y neuróticos en Buenos Aires (1880-1900). Entre médicos, boticarios y mercaderes
Authors: Maya González José Antonio
Published: June 2022

Mauro Vallejo, Nerviosos y neuróticos en Buenos Aires (1880-1900). Entre médicos, boticarios y mercaderes, Barcelona, España/Buenos Aires, Argentina, Miño y Dávila Editores, 2021, pp. 225
Estudo da Unidimensionalidade da Escala para Avaliação da Qualidade dos Objetos de Aprendizagem da Área da Saúde (Equalis-OAS)
Authors: Trindade Carolina Sturm , Kato Sérgio Kakuta , Correa Ana Paula Borngraber , Rodrigues Ylana Elias , Gonçalves Marcelo Rodrigues , Hauck Filho Nelson , Reppold Caroline Tozzi
Published: June 2022

No presente estudo foi investigada unidimensionalidade, o funcionamento das categorias de resposta e a fidedignidade para a Equalis-OAS, uma escala Likert, com cinco pontos, escrita em Língua Portuguesa, desenvolvida sob a ótica dos preceitos psicométricos, com vistas a avaliar a Qualidade de Objetos de Aprendizagem da Área da Saúde. O estudo envolveu 1.766 profissionais de saúde, participantes de cursos de educação continuada realizados na modalidade a distância disponibilizados pelo Telessaúde do Rio Grande do Sul (TelessaúdeRS-UFRGS). Os resultados sugerem que, embora a Equalis-OAS tenha seus itens distribuídos em três categorias (Conceitos Intrínsecos; Educacional; Apresentação) a adoção da unidimensionalidade pode ser adotada, sem comprometer a confiabilidade da escala. Além disso, o ponto "não concordo nem discordo" da Equalis-OAS mostrou ser pouco relevante, sugerindo futuras aplicações com quatro pontos. O cálculo do Rating Scale aponta que os parâmetros de pessoas e itens foram estimados com elevada precisão, indicando evidências de confiabilidade da escala. As análises realizadas abarcando à unidimensionalidade do instrumento, a exclusão de um item e a exclusão do ponto neutro não comprometeram as evidências de validade do instrumento, ou seja, a Equalis-OAS permanece medindo o que se propõe a medir, isto é, a qualidade de objetos de aprendizagem voltados a área da saúde.
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Palavras-chave: Educação a distância. Educação em saúde. Estudos de validação. Teoria de resposta ao item.
La procedencia de la Acción de Protección contra particulares en el Ecuador
Authors: Abad Jara Sebastian , Eguiguren Calisto Roberto
Published: June 2022

El presente artículo analiza los mecanismos jurisdiccionales previstos en la Constitución del Ecuador para la protección de derechos frente a agentes no estatales. Se estudia el desarrollo legal y jurisprudencial de las cinco causales de procedencia de la acción de protección en contra de particulares: cuando estos prestan servicios públicos propios o impropios, generan daño grave, o colocan a la persona en estado de subordinación, indefensión o discriminación. Además, se busca identificar supuestos prácticos en los cuales la vulneración de derechos cometida por privados habilita a la justicia constitucional a conocer, resolver y reparar un caso.
La política de prevención del embarazo en niñas y adolescentes y los derechos del niño
Authors: Ruiz Luzardo Jean Pierre
Published: June 2022

Este artículo analiza la Política Intersectorial de Prevención del Embarazo en Niñas y Adolescentes en Ecuador periodo 2018-2025, desde tres aspectos: 1) el enfoque de los derechos del niño; 2) el principio de autonomía progresiva; y, 3) la Educación Integral en Sexualidad (EIS). La metodología empleada consistió en la comparación de la normativa internacional y lo establecido en la política. Finalmente, se concluye que este instrumento no contempla dichos elementos en su diseño.
Compliance Programs y su incorporación en la legislación penal ecuatoriana
Authors: Bayancela Mariana Toali
Published: June 2022

La responsabilidad penal de la persona jurídica se estableció en Ecuador en el año 2014 con la entrada en vigor del Código Orgánico Integral Penal; sin embargo, la normativa sobre los programas de cumplimiento recién fue incorporada en febrero de 2021, con la llamada “Ley Anticorrupción”, el legislador reforma los artículos 45 y 49 del COIP e inserta a los compliance programs como circunstancia atenuante de la responsabilidad penal de la persona jurídica. La atenuante está basada en la existencia de sistemas de integridad, normas, programas y las respectivas políticas de cumplimiento. En este contexto, la normativa reciente precisa de análisis, por tanto, en el presente texto se tiene como fin hacer un breve estudio del modelo ecuatoriano de responsabilidad penal de la persona jurídica y de los compliance programs, sus requisitos y los desafíos que la reforma plantea a la materia.
La relación entre el Derecho y la Literatura
Authors: Obando Angeles
Published: June 2022

En esta entrevista, Jorge Luis Roggero analiza, a partir de diversos enfoques, las implicaciones del estudio del movimiento Derecho y Literatura. La entrevista aborda temas relacionados con la teoría crítica del Derecho, la Filosofía del Derecho, así como la expansión del fenómeno jurídico-literario en Latinoamérica. El experto destaca la influencia que ha tenido en su trabajo la obra de Jacques Derrida. Finalmente, la entrevista concluye con una reflexión sobre el desarrollo y la expansión de la disciplina Derecho/Literatura en América Latina.
Designing an Emergency Information System for an Emergency Information System for Catastrophic Natural Situations
Authors: Papatheodosiou K. , Angeli C.
Published: June 2022

Natural disasters have brought about irreparable damage to humans, human activity, society, and the economy, and their effects will probably be increased in the future due to climate change. However, the extent of a natural disaster could be diminished if both individuals and authorities are informed of an impending emergency situation. Therefore, the research interest has been directed into developing robust Emergency Information Systems. This paper demonstrates the way a specific Emergency Information System could be designed to deliver alert messages. The system was designed on the base of the DRM standards and was put into action in the region of Vigla, an area located in Symi, one of the Dodecanese islands. The coverage test proved that the system operates well in remote areas that are characterized by rough geographic terrain.
A Return to “A Complexity Context to Classroom Interactions and Climate Impact on Achievement”
Authors: Cochran Joseph , Johnson Liz
Published: June 2022

When JPCS published “A Complexity Context to Classroom Interactions and Climate Impact on Achievement” in 2017, the article was a cutting-edge application of ABM to classroom dynamics. Five years later, though, there have been dramatic changes to education as a result of the COVID-19 pandemic. While the technology of ABM has advanced sufficiently that reexamining of the topic may be justified, the trauma caused by the pandemic should make us question whether any such model would accurately reflect the real world. Given the isolating nature of COVID-19 and online learning, the purpose of this article is to remind us that in a classroom environment, “every interaction matters.” Effective action steps can easily be taken to dramatically strengthen interactions and thus strengthen leaning networks, which will lead to higher levels of achievement. This can be done by the means of simple strategies like increasing positive climate behavioral markers in the classroom, like using student names, checking-in with students, smiling, using polite language, laughing, and clapping. In contrast, negative behavior markers like anger, sarcasm, irritability, harsh voice, yelling, exclusion of students, bad language, physical control of students, teasing, and bullying must be eradicated.
Outcome of Cochlear Implantation in Deaf Children with Co-Existing Otitis Media with Effusion
Authors: Al Habsi Sami , Al Zaabi Khalid , Al Lawati Ammar
Published: June 2022

Objective: Cochlear implantation (CI) is the definitive treatment for profound hearing loss in children and adults. Operating on an infected ear is considered a challenge; the institution of cochlear implant the presence of otitis media with effusion (OME) prior to CI surgery has created a debate among neuro-otologists: treat the OME first or go ahead with surgical intervention. This study was conducted to determine whether cochlear implantation in patients with OME at the time of surgery has any influence on the procedure, post-operative complications and surgical outcome. Methods: Retrospective descriptive analysis of data collected from records of patients who underwent CI in a tertiary care hospital from 2000-2018 was done. The age targeted was 6 months to 14 years old, excluding all adults, and those who had their operations outside the chosen institution. Results: Out of 369 children, 175 had OME preceding surgery compared to 194 who did not have OME. Intra-operative oedematous hypertrophied middle ear mucosa was observed only in OME patients (n=18, P <0.050). Moreover, among the OME patients, six cases developed mild intra-operative bleeding compared to only one case from non-OME group (P <0.050). Overall, there was no significant difference in post-operative surgical complications between the two groups (P >0.050). Conclusion: The presence of OME is associated with intra-operative technical difficulties, such as impaired visualization and bleeding. However, OME is not determinative on performing cochlear implantation in terms of post operative complications and outcome. Therefore, there is no need to delay the implantation until the OME resolves.

Keywords: Cochlear implantation, otitis media with effusion, children, and sensorineural hearing loss
Analysis of the Work-family Conflict in Small Companies in the South Colombian Region: The Differential Perception between Men and Women
Authors: Juan M. Andrade , Alfonso Manrique , Fernando A. Fierro
Published: June 2022

The present investigation was carried out with the objective of measuring the perception of the work-family conflict, experienced by men and women, in the organizations of the Surcolombiana region. In this sense, the deductive method was used, in a quantitative and descriptive study, since it was attempted to determine the level of perception of the variable in question, for which the Survey Work-Home Interaction-Nijmegen scale was used (SWING) for work-family conflict, validated internationally, on a sample of 397 people. The analysis of the information and the relationship of variables was carried out with the SPSS 25 software. In this regard, it was found that in general all the collaborators present high levels of work-family conflict; however, it is evident that women who work in organizations experience higher levels of work-family conflict, compared to men.
Violence in Cyberspace and Possible Prevention
Authors: Bećirović-Alić Maida , Saračević Muzafer
Published: June 2022

This paper describes some of the forms of violence in cyberspace and possible prevention. The second part of this paper provides an analysis of students’ views on possible online abuse and prevention. The research aims to highlight statistically significant opportunities for raising awareness of possible online abuse and the prevention of cyberbullying. The survey consists of a total of 20 testimonials, which are divided into 4 parts, and each part assesses different aspects. The conclusion of this research is that the Internet environment does not provide enough feedback on the reactions of the person to whom the harassing messages were sent, which in the abuser reduces the feeling of causing true emotional and psychological harm to another person, reducing the degree of self-control and insight into the level of bullying.
Zgodnje učenje tujega jezika nemščine v besedi in sliki otrok v vrtcu
Authors: Jazbec Saša
Published: June 2022

V članku obravnavamo zgodnje učenje tujih jezikov (ZGTJ) oz. uspešno posredovanje tujega jezika mlajšim otrokom v vrtcu. V teoretičnem delu je predstavljeno zgodnje učenje tujega jezika kot konstantno aktualna tema v javnosti, stroki in znanosti. Medtem ko znanost ne dvomi o pomenu ZGTJ, se zdi, da obstaja v javnosti vrsta argumentov proti ZGTJ, ti so bodisi jezikovno-politični, tehnokratski bodisi finančni. Zgodnje učenje tujega jezika že v vrtcu je po našem mnenju zelo pomembno in nujno, vendar mora biti izvedeno strokovno, kakovostno in skladno z razvojnimi potenciali otrok. V empiričnem delu je pokazano, kako vidijo in doživljajo tuji jezik (v tem prispevku nemščino) otroci in kako ga opišejo z risbami in z besedami. Njihove risbe in izjave so zanimive, povedne in hkrati vredne analize in premisleka. Pri ZGTJ v vrtcu mora pridobivanje jezika prevladati nad učenjem jezika, zato na koncu poudarjamo pomen kognitivno in razvojno primernih (ne preenostavnih, ne prezahtevnih) vsebin in didaktičnih postopkov v vrtcu.
Who is the Potential Microchip Implant User?
Authors: Vovk Maryna , bagiaa Alenka , Bevanda Vanja , Zakonnik Lukasz , Maltseva Daria , Moissev Stanislav , Pavliček Antonin , Fischer Jakub , Rostanski Maciej , Žnidaršič Anja , Weber Borut
Published: June 2022

The passive radio frequency identification microchip implants are known to be a subject of intense debate and argument about their advantages and disadvantages. While one group sees the opportunities of microchip implants in healthcare and the positive impact on life, the other group emphasizes a variety of issues related to privacy, impact on the human body, and others. Given recent changes in lifestyle and other areas, it is reasonable to assume that microchip implants are an inevitable part of our future. The purpose of this study was to determine the characteristics and habits of potential future users. Using a sample of survey participants from four European countries, we conducted a cross-sectional study. The regression model was used to test our research question, which aimed to identify predictors of willingness to use microchip implants. The results show that the potential microchip implant user is male, has multiple social media profiles, and has a history of losing wallets, keys, or ID cards. He uses online shopping and group purchases and has a number of loyalty cards. According to the sample results, age is not a significant predictor of microchip implant use.
Nutritional and Bioactive Properties of Rubus ulmifolius Schott (Blackberry): A Review
Authors: Chauhan Ekta Singh , Chauhan Urvashi
Published: June 2022

Rubus ulmifolius Schott, commonly known as blackberry, has been widely used as a food source as well as in jams, juices, etc. for its purported medical benefits. It has also been extensively investigated for its nutritional and bioactive constituents, which might be responsible for these benefits. In general, the plant is rich in carbohydrates, lipids, vitamins and minerals. The primary carbohydrates are glucose and sucrose; while ascorbic acid has been reported to be the primary vitamin, contributing to the acidic nature of the fruits. The bioactive compounds identified in the various plant parts include polyphenols such as phenolic acids, flavonoids and anthocyanins and other chemicals in lesser amounts. The antioxidant and antimicrobial properties of various parts of the plant have been investigated. The antioxidant effect has been attributed both to the presence of ascorbic acid as well as the other polyphenolic compounds. An antimicrobial activity has also been reported against the common human pathogens. This review summarizes the prevailing literature on the nutritional and bioactive composition of the plant and the evidence for its antioxidant and antimicrobial properties. This review summarizes the prevailing literature on the nutritional and bioactive composition of the plant and the evidence for its antioxidant and antimicrobial properties.
​Shelf Stability of Optimized Dahi Prepared using Functionally Active Lactic Cultures
Authors: Rajasekhar P. , Prabha R. , Ramachandra B.
Published: June 2022

Background: Subjecting the optimized dahi prepared using functionally active lactic cultures.
Methods: During the period from 2012 to 2013, the wild strains of lactic isolates such as L. lactis ssp. lactis LC14 producing lactic acid; diacetyl and slime producing L. mesenteroides ssp. mesenteroides Leu8, probiotic nature (acid and bile tolerant) of S. thermophilus ST3 and only bile resistant L. delbrueckeii ssp. bulgaricus Lb32 were selected as they set the milk in 18 hours with good DMC and reasonable LA% for dahi preparation.
Result: The above mentioned LAB were combined for dahi preparation at 1% inoculum of each of 0.25% showed titratable acidity of 0.63 and DMC of 8.32 with 1 ppm of diacetyl; 180 ppm of exopolysaccharide or slime with sensory score of 7.6. The optimized dahi can be called as probiotic dahi due to addition of probiotic culture S.thermophilus ST3 along with other cultures. Upto 5 days and 11 days dahi could be stored at room temperature (24°C) and refrigeration temperature (7°C) was in good condition with acceptable quality respectively.
​Effect of Non-genetic Factors on Reproductive Parameters and Greasy Fleece Yield in Kashmir Merino Sheep
Authors: Rather Mubashir Ali , Bashir Imran , Malik Tariq Ahmad , Ahmad Ishfaq
Published: June 2022

Background: A study was undertaken to estimate gestation length, birth weight, dam weight and greasy fleece yield in Kashmir Merino sheep and factors influencing these traits at Sheep Breeding Farm, Kralpathri in 2020-21.
Methods: The traits considered in the study were overall all body weight of dams at tupping (DWT), average wool yield of dams (AWY), gestation period (GP) and birth weight (BW). The averages of 39.00±0.27 (kg), 2.38±0.02 (kg), 150.17±0.17 (days) and 3.87±0.04 (kg) for DWT, AWY, GP and BW with coefficient of variation 12.83%, 12.75,1.65 and 17.70, respectively were observed in the present study. The data was analyzed by Harvey, 1990.
Result: Highest and lowest CV (%) was observed for BW and GP, respectively. Overall estimates of 37.43±0.41 (kg) and 2.21±0.02 (kg), 150.59±0.56 and 2.84±0.11 for DWT, AWY, GP and BW, respectively was observed in the present study. Effect of age of dam was significant (p less than 0.05) on DWT and AWY whereas effect of lamb weight at birth was significant on GP. The effect of genetic group of sire, dam weight, parity of dam, body weight of dam at tupping, sex and birth type of lamb had significant (p less than 0.05) effect on BW. Heaiver lambs were born to heavier dams. Therefore, increasing selection pressure at tupping for dam weight will result in improvement of birth weight and hence overall production performance of Kashmir Merino sheep.
Effects of Anaesthetic Protocol on Kidney and Liver Function of Female Dogs undergoing Ovariohysterectomy
Authors: Kumar Rajesh , Das A.K. , . Aakanksha , Verma N.K. , . Aakash , Saxena A.C. , Hoque M.
Published: June 2022

Background: Nearly all anaesthetic agent decreases renal and hepatic blood flow, so anaesthetic agents should be selected properly in patients particularly with pre-existing renal and hepatic impairment. The present study conducted to evaluate the effect of acepromazine, midazolam and dexmedetomidine as pre-anaesthetic agent followed by induction with propofol and maintenance with isoflurane on kidney and liver function of client-owned female dogs undergoing elective ovariohysterectomy. Methods: Thirty-two clinically healthy female dogs were randomly divided into four groups with ten animals in the groups A and B and six animals in groups C and D for elective ovariohysterectomy. Animals were premedicated with acepromazine-butorphanol in group A, midazolam-butorphanol in group B, dexmedetomidine (I/M)- butorphanol in group C and dexmedetomidine (I/V)- butorphanol in group D. Animals in all four groups were induced (till effect) with propofol and maintained with isoflurane. Result: All the groups showed non-significant marginal decline in BUN and serum creatinine at 5 minutes after pre-medication. Serum AST and ALT were non-significant decreased in groups A and B and non-significant increase in groups C and D during observations. Serum albumin and globulin gradually but non-significantly decrease in group A after premedication to T20 during anesthesia with isoflurane, then gradually increase upto extubation, but values remained lower in comparison to base values.
Effect of Feeding Awassi Lambs after Weaning with Protected Methionine on Productive Performance and Carcass Traits
Authors: Tayeb M.A.M. , Almallah O.D. , Alkurjia O.A.
Published: June 2022

Protected amino acids especially methionine and lysine are considered one of the most important additives to the feed of high growth or production animals and the response may depend or affected by the balance between the amino acids and energy requirements. Local Awassi lambs (6 to 9 months of age) in the previous studies showed altered responses to the feeding protected protein. The current study aimed to investigate the effect of protected methionine to the feed of lambs after weaning on growth and carcass traits. Ten Awassi lambs were used in this study ages 4 to 5 months and average body weights 22.81±0.48, lambs were divided into two treatments and fed using ad-libitum system at two meals daily on control diet in the first treatment or with addition 5 g/lamb/day of protected methionine in the second treatment. Our result was showed that feeding Awassi lambs with protected methionine directly after weaning decreased feed intake, final body weight, total gain as compared with control, but carcass traits such as hot carcass weight, dressing percentage, rib-eye muscle area and subcutaneous fat thickness were not affected.
In dogs with atopic skin disease, is lokivetmab more effective than oclacitinib in reducing the score of a recognised scoring system?
Authors: Cheung Bonnie Yuan Tone
Published: June 2022

PICO question

In dogs with atopic skin disease, is lokivetmab more effective than oclacitinib in reducing the Canine Atopic Dermatitis Lesion Index score (or some other recognised scoring system)?

 

Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

One randomised controlled trial and one before and after study were critically appraised

Strength of evidence

Weak

Outcomes reported

One randomised controlled trial studied the effects of lokivetmab and oclacitinib and found that both drugs were similar in reducing the Canine Atopic Dermatitis Lesion Index (CADESI-03) score.

An additional study was evaluated but had non-standardised data as it was a before-and-after study on use of lokivetmab. The paper noted that dogs’ response to oclacitinib can be used to predict how well these dogs respond to lokivetmab. This study also reported a reduction in Pruritus Visual Analog Scale (PVAS) score between before and after lokivetmab administration

Conclusion

In view of the strength of evidence and outcomes from the studies, there is insufficient quality of evidence to answer the PICO question and so further comparative study is required

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Test Difficulty in Second Language Setting: Measuring With Receiver Operating Characteristic
Authors: Figueiredo Sandra , Martins Margarida Alves
Published: June 2022

In order to assess the accuracy and validity of proficiency diagnostic tests in Second Language (L2), specifically regarding the linguistic (orthographic, semantic, syntactic, lexical) and cognitive (verbal reasoning, lexical decision) components for the immigrant population in Portugal, a study of cut-off points of 6 tests was conducted. This study was motivated by the unknown tests and the gap concerning the testing and rating of individuals in L2 settings, different from English as L2. The objective was to validate and inform about new tests (and how to establish rating scores and understand the proficiency level of students) in Second Language Testing (for European Portuguese) especially concerning different psychometrics for specific skills (e.g., phonemic blending). In this way, we contribute to identify new procedures for schools and professionals about testing of cognitive functions in immigrant populations. First, we examined 108 non-native students attending Portuguese schools, aged 7–17 years, speakers of mother tongues other than Portuguese and residing in Portugal for a period not exceeding eight years. Then, series of univariate analyses, non-parametric tests and the calculation of percentiles enabled the subsequent classification of the subjects’ proficiency levels: With or without proficiency. Several levels were identified. The sensitivity and specificity indexes were calculated using the Receiver Operating Characteristic (ROC) analysis to define the cut-off points for each test. The score calculation took into account the chronological age, age of immigration and gender variables. The evidence from this study suggests that all tasks are suitable to assess immigrant students. However with the ROC analysis, this assessment differs regarding degrees of proficiency between groups given the characteristics of the tasks and of the subjects. The importance of doing tests with discriminatory power of the subjects’ performance to be able to intervene in the linguistic and cognitive areas with the greatest deficit is examined here.
Evidence Review: COVID-19 Recovery in South Asian Urban Informal Settlements
Authors: Aslam Saba , Schmidt-Sane Megan
Published: June 2022

The global pandemic has brought renewed attention toward the everyday challenges in informal settlements. COVID-19 reminds us that southern urban life is rooted in ‘collective’ experiences where toilets and kitchens are shared by multiple families; where the categories of work and home, private and public space overlap; and where the majority live in vulnerable conditions. Despite these challenges, some of the most innovative and collective responses to COVID-19 have emerged from these areas. While informal settlements did face a host of risks and vulnerabilities during the pandemic, local responses have highlighted the resilience of informal settlement communities. However, few informal settlements are actually ‘resilient’ and any local responses must be robustly supported by system-wide change including support from local and national governments, improvements to built infrastructure, and improved access to health care services, among other priorities. The category of ‘informal settlements’ also captures a wide range of settlement types, from a legal slum to an informal settlement with no legal status, with many other types in between. This underscores the need to address fundamental issues that ‘perpetuate conditions of inequity, exclusion and vulnerability’ while also recognising the needs and contexts of different kinds of informal settlements. Whether COVID-19 helps governments recognise conditions of insecurity and vulnerability to address safe and secure housing and infrastructures remains to be seen. This is an update to the previous SSHAP brief on ‘COVID-19 in Informal Urban Settlements’ (March 2020). This evidence review highlights local responses, grassroots efforts, and challenges around COVID-19 recovery within urban informal settlements in South Asia. It focuses on specific examples from Karachi, Pakistan and Mumbai, India to inform policy responses for COVID-19 recovery and future epidemic preparedness and response. We show how local level responses are shaped in these cities where national and international responses have not reached communities at municipal and sub-municipal levels. This brief was written by Saba Aslam (IDS Alumni) and Megan Schmidt-Sane (IDS), with reviews from Professor Amita Bhide (Tata Institute of Social Sciences, India), Dr Asad Sayeed (Collective for Social Science Research, Pakistan), Annie Wilkinson (IDS), and contributions from Swati Mishra (LSHTM), Prerana Somani (LSHTM), Saleemullah Odho (Deputy Commissioner, Korangi district Karachi), Dr Noman Ahmed (NED University, Karachi), Tahera Hasan (Imkaan Foundation, Karachi), Atif Khan (District Health Officer, Korangi district Karachi), Dr Harris (District Focal person, Korangi), Aneeta Pasha (Interactive for Research and Development, Karachi), Yasmeen Shah (Pakistan Fisherfolk Forum), Ghulam Mustafa (HANDS Pakistan), and Dr Shehrin Shaila Mahmood (icddr,b). This brief is the responsibility of SSHAP.
Computer Simulation of Load-Handling Device of Automatic System for Unloading-Supply of Rail Straps at Rail Welding Enterprise RWE-1
Authors: Atamanyuk Aleksandr , Vatulin Yan , Vorob'ev Aleksandr , Novosel'skiy Igor'
Published: June 2022

Purpose: Modernization of rail unloading-supply technology of rail unloading-supply automatic system with the development of multifunctional rail grip and the definition of compliance degree of being used I-beam 36M as a monorail to new requirements for a strength. Methods: Computer modeling of solid virtual model of being designed rail grip is developed in the environment of computer-aided design system SolidWorks. Results: Load-carrying beam of unloading-supply automatic system (USAS) lifting device with a new grip is calculated. It’s found that the I-beam as of 36M grade fully meets required strength and rigidity conditions at installing a new grip on a solid plot. Practical significance: Design of automatic rail grip is designed that’s reckoned upon work with one or three rails simultaneously.
Preparation Improvement of the Results of Engineering- Hydrometeorological Research for Transport Infrastructure Facility Projection
Authors: Samofalov D. , Shkurnikov Sergey , Golubcov Vladimir
Published: June 2022

Purpose: Peculiarities and problems that should be considered, when preparing reports on engineeringhydrometeorological research, for project documentation development. Scientific-technical support of reporting documentation on engineering research for linear objects showed the need in some cases to create climate models and maps of being studied parameters distribution. The importance of the development of meteorological observation research institution is pointed out because being obtained data are critical for being projected facility row. Recommendations, on the example of meteorological parameters, on design of distribution maps for being investigated parameters and on drawing graphs for these parameters value change along being projected linear objects. Methods: Analysis and comparison of the results on engineering hydrometeorological research, given assessment of sufficiency of the presented data, while solving applied tasks on linear objects. Results: Need to increase in some cases the number of involved meteorological stations for the possibility to create distribution maps for being studied parameters was established. An example is presented and the comparison of distribution maps, created using data from reporting documentation, with those created from additional information was made. It was also found that existing network of hydrometeorological stations on the territory of the Russian Federation is insufficient to obtain results of necessary accuracy, especially, when designing linear objects as well as objects located along the route of being projected line. Practical importance: The possibility of using maps of hydrometeorological parameters distribution for to obtain data in areas, being remote from hydrometeorological stations, has been demonstrated. It is concluded that it’s necessary to increase the number of observation stations for being studied parameters that will reduce the ambiguity in hydrometeorological calculations when determining the parameter values for to justify projection decisions
Development Perspectives of High-Speed Railway Network in the World in the Next Decade
Authors: Grinemayer Anna , Anikin Il'ya , Parfenenko Roman , Izvarin Mihail
Published: June 2022

Purpose: To find main conceptions of the development of high-speed lines in the world, to outline leading countries in the sphere of high-speed railway network construction, to track high-speed railway network construction dynamics, to compare the shares of high-speed railways by individual continents and countries, to define Russia’s place in the sphere of high-speed transport, to outline individual country and continent perspectives for new high-speed line construction and new technology application during construction of the lines in the next decade. Methods: Comparison of construction scales for the outlined high-speed lines by individual countries, graphical analysis of high-speed network growth dynamics in five the most developed by this matter countries. Results: Leading countries in the sphere of high-speed transport network construction are distinguished, relevant values for volumes of existing high-speed network in the world different parts and some countries are presented, a classification of Russia passenger trains depending on the motion speed is given, specificities of organization of high-speed communication in our country are outlined, plans for new high-speed line construction in China, Russia and other countries are expounded, statistical data on high-speed railway spread in the world countries and by individual continents are presented, high-speed network construction dynamics in China, Japan and leading by this matter Europe countries is shown. Practical significance: The given article can serve as a basis for an acquaintance with a relevant status on the matter of existing high-speed railway transport networks, major countries are outlined herein which experience can be taken while creation of high-speed lines in Russia and being based on demonstrated graphical materials, it’s eventual to evaluate real perspectives by the volume of construction of high-speed network nowdays.
Formation of a Competitive Environment on the Example of Transport Potential by the Method of Organizing Passenger Flow Based on “Dry Feet” Principle
Authors: Shmanev Timofey , Ul'yanickaya Viktoriya , Gorbunova Marina , Sitnikov Aleksey , Fedorova Nataliya
Published: June 2022

Purpose: Formation of the system of transport potential and universalization of a railway and urban (municipal) transport system for a passenger flow according to “dry feet” principle. Methods: The main tools for the analysis and management of a passenger complex at implementation of ongoing activities are: cause-and-effect links, algorithmization, mapping, data analysis, etc. Results: Variant for organization and implementation of ergonomic and rational planning of space of railway and urban environment by the method of passenger flow organization based on the principle of “dry feet” is presented. Practical importance: using the obtained algorithm (sequence) as an example, to provide a client with an unhindered and comfortable pass along an entire route: from a route beginning, along a route, during transfers and a route end regardless of transport mode used.
Christopher Kempf, Craft Class: The Writing Workshop in American Culture
Authors: Wardcantori Maxi
Published: June 2022

A review of Craft Class: The Writing Workshop in American Culture, by Christopher Kempf
Arjun Appadurai and Neta Alexander, Failure
Authors: Hossain Shahin
Published: June 2022

A review of Failure by Arjun Appadurai and Neta Alexander
Role of extracellular vesicles secretion in paclitaxel resistance of prostate cancer cells
Authors: Kumar Ashish , Kumar Pawan , Sharma Mitu , Kim Susy , Singh Sangeeta , Kridel Steven J. , Deep Gagan
Published: June 2022

Aim: The development of chemotherapy resistance is the major obstacle in the treatment of advanced prostate cancer (PCa). Extracellular vesicles (EVs) secretion plays a significant role among different mechanisms contributing to chemoresistance. Hence, inhibition of EVs release may increase the efficacy of chemotherapeutic drugs against PCa. Methods: Paclitaxel (PTX) resistant PCa cells (PC3-R and DU145-R) were treated with GW4869, a known exosome biogenesis inhibitor. EVs were isolated from the conditioned media by ExoQuick-based precipitation method and characterized for concentration and size distribution by nanoparticle tracking analysis. The effect of GW4869 treatment on the survival and growth of PCa cells was assessed by MTT, and colony formation assays in vitro, and ectopic PC3-R xenografts in male athymic nude mice in vivo. The effect of other EV biogenesis inhibitors, imipramine and dimethyl amiloride (DMA), treatment was also analyzed on the survival of PC3-R cells. Results: GW4869 (10-20 µM) treatment of PTX resistant PCa cells significantly reduced the release of small EVs (50-100 nm size range) while increasing the release of larger EVs (> 150 nm in size), and inhibited their clonogenicity. Moreover, GW4869 (5-20 µM) treatment (24-72h) significantly inhibited the survival of PC3-R cells in a dose-dependent manner. We observed a similar growth inhibition with both imipramine (5-20 µg/mL) and DMA (5-20 µg/mL) treatment in PC3-R cells. Furthermore, GW4869 treatment (IP) in mice bearing PC3-R xenografts significantly reduced the tumor weight (65% reduction, P = 0.017) compared to the vehicle-treated control mice without causing any noticeable toxicity. Conclusion: Inhibiting the release of EVs could sensitize the resistant PCa cells to chemotherapy.
Function Consuming sebagai Tingkat Kecakapan Literasi Media Digital Masyarakat Yogyakarta
Authors: Irma Sukmawati Ade , Handayani Irma
Published: June 2022

Digital competence is one of the skills for users in using digital media. Research on mapping the digital competence category of the people of Yogyakarta was carried out to know the media digital positioning competence of digital media users. The position of digital media user skills is categorized by the k-NN (k Nearest Neighbor) technique data mining method. The objective of this research using the k-NN technique data mining method was carried out by compiling categories that refer to attributions where the attribution refers to the ten competencies of Japelidi's digital media users. The digital media user skills category has four quadrants: Function Consuming, Function Prosuming, Critical Consuming, and Critical Prosuming. This research was conducted in Yogyakarta from June-July 2020 because, during this period, there was a surge in digital media users due to the pandemic. The findings in this research provide information that the competence of using digital media for Yogyakarta residents in the period of June-July 2020 is in the Function Consuming section, and it is in the first quadrant
Addressed Combined Fiber-Optic Sensors as Key Element of Multi-Sensor Greenhouse Gas Monitoring Systems
Authors: Morozov Oleg G. , Tunakova Julia A. , Hussein Safaa M. R. H. , Shagidullin Artur R. , Agliullin Timur A. , Kuznetsov Artem A. , Valeev Bulat I. , Lipatnikov Konstantin A. , Anfinogentov Vladimir I. , Sakhabutdinov Airat Zh.
Published: June 2022

The design and usage of the addressed combined fiber-optic sensors (ACFOS) and the multisensory control systems of the greenhouse gas concentration on their basis are investigated. The main development trend of the combined fiber-optic sensors (CFOS), consisting of the fiber Bragg grating (FBG) and the Fabry-Perot resonator (FPR), which are successively formed at the optical fiber end, is highlighted. The addressed fiber Bragg structures (AFBS) usage instead of the FBG in the CFOS leads not only to significant cheapening of the sensor system due to microwave photonics interrogating methods, but also to increasing its metrological characteristics. The structural scheme of the multisensory gas concentration monitoring system is suggested. The suggested scheme allows detecting four types of the greenhouse gases (СО2, NO2, CH4, OX) depending on the material and thickness of the polymer film, which is the FPR sensitive element. The usage of Karunen-Loeff transform (KLT), which allows separating each component contribution to the reflected spectrum according to its efficiency, is proposed. In the future, it allows determining the gas concentration at the AFBS address frequencies. The estimations have shown that the ACFOS design in the multisensory system allows measuring the environment temperature in the range of −60…+300 °C with an accuracy of 0.1–0.01 °C, and the gas concentration in the range of 10…90% with the accuracy of 0.1–0.5%.
Metagenome-Assembled Genome of Cyanocohniella sp. LLY From the Cyanosphere of Llayta, an Edible Andean Cyanobacterial Macrocolony
Authors: Vilo Claudia , Dong Qunfeng , Galetovic Alexandra , Gómez-Silva Benito
Published: June 2022

Cyanobacterial macrocolonies known as Llayta are found at Andean wetlands and consumed since pre-Columbian times in South America. Macrocolonies of filamentous cyanobacteria are niches for colonization by other microorganisms; however, the microbiome of edible Llayta has not been explored. Based on a culture-independent approach, we report the presence, identification and metagenomic genome reconstruction of Cyanocohniella sp. LLY associated to Llayta trichomes. The assembled genome of strain LLY is now available for further inquiries, and may be instrumental for taxonomic advances on this genus. All known members of the Cyanocohniella genus have been isolated from salty European habitats. A biogeographic gap for the Cyanocohniella genus is partially filled by the existence of strain LLY at Andes Mountains wetlands in South America as a new habitat. This is the first genome available for members of this genus. Genes involved in primary and secondary metabolism are described providing new insights on the putative metabolic capabilities of Cyanocohniella sp. LLY. The reconstructed genome of strain LLY is now available and instrumental for further inquiries and taxonomic advances on the genus Cyanocohniella.