bluuebunny/crossref_metadata_2025 huggingface dataset:
Aggressions on Social Networks: What Are the Implications for Healthcare Providers? An Exploratory Research
Authors: La Regina Micaela , Mancini Arianna , Falli Francesco , Fineschi Vittorio , Ramacciati Nicola , Frati Paola , Tartaglia Riccardo
Published: June 2021

Incidents of violence by healthcare users against staff have been considered as sentinel events. New forms of aggression, i.e., cyberbullying, have emerged with the advent of social networks. Medical literature includes some reports about workplace cyberbullying on nurses and young doctors by colleagues/supervisors, but not by users. To investigate cyberbullying on healthcare providers via social networks, we carried out an exploratory quali-quantitative study, researching and analyzing posts and comments relating to a local Health Trust (ASL5) in Italy, published from 2013 until May 2020 on healthcare worker aggressions on social networks on every local community’s Facebook page. We developed a thematic matrix through an analysis of the most recurring meaning categories (framework method). We collected 217 texts (25 posts and 192 comments): 26% positive and 74% negative. Positive posts were shared about ten times more than negative ones. Negative comments received about double the “Likes” than the positive ones. Analysis highlighted three main meaning categories: 1. lack of adequate and functional structures; 2. negative point of view (POV) towards some departments; 3. positive POV towards others. No significant differences were observed between the various categories of healthcare workers (HCW). Geriatric, medical wards and emergency department were the most frequent targets of negative comments. All the texts referred to first-line operators except for one. Online violence against HCW is a real, largely unknown, problem that needs immediate and concrete attention for its potentially disastrous consequences. Compared to traditional face-to-face bullying, it can be more dangerous as it is contagious and diffusive, without spatial, temporal or personal boundaries.
Preconception Care for Men and Women during the Pandemic, an Intervention Proposal
Authors: Rovira-Vizcaíno Nieves Estrella , Sáez-Padilla Jesús , Romero-Márquez José Manuel , Merino-Godoy María de los Ángeles
Published: June 2021

The COVID-19 pandemic and its measures resulted in limited outdoor activities, reduced group meetings, etc., leading to unhealthy habits. Several studies showed how certain unhealthy habits can lead to serious consequences for both men and women, as well as affect future offspring. (1) Background: Therefore, we present a community intervention at the preconception stage to avoid future risks. The purpose of this intervention is to change lifestyles and beliefs about the health of men and women in the preconception period; (2) Methods: For the design of the intervention, a bibliographic search was performed both in English and Spanish in the main databases of health sciences and nursing (Cochrane, PubMed, Web of Science, CINAHL, LILACS, Dialnet), using descriptors in MeSH health for sciences; (3) Results: We proposed that a variety of lifestyles be analyzed, including aspects such as physical activity, nutrition, etc. In addition, stress management should be emphasized through a relaxation workshop, where three different techniques be proposed to reduce anxiety levels in stressful situations; (4) Conclusions: Due to the limited scientific results of interventions carried out in the preconception period simultaneously with men and women, more community interventions that address this topic are needed to assess the impact of these actions on the health of the population.
Regular Taekwondo Training Affects Mood State and Sociality but Not Cognitive Function among International Students in South Korea
Authors: Bae Ju-Yong , Roh Hee-Tae
Published: June 2021

We aimed to investigate the effect of Taekwondo training on physical fitness, mood, sociality, and cognitive function among international students in South Korea. We randomly assigned 24 international students to a control group (CG, n = 12) and experimental group (EG, n = 12). The EG performed Taekwondo training for 16 weeks, while the CG did not train. Each participant underwent a physical fitness test and sociability questionnaire before and after the intervention. We also examined changes in mood state and cognitive function, using the Korean version of the Profile of Mood State-Brief (K-POMS-B), and the Stroop Color and Word test, respectively. Regarding the physical fitness variables, sit-and-reach records in the EG significantly increased after intervention (p < 0.05). In the sub-variable of K-POMS-B, Vigor-Activity scores significantly increased (p < 0.05) after intervention, while the Fatigue-Inertia scores significantly decreased in the EG (p < 0.05). Furthermore, in the EG, peer relationship scores, a sub-variable of sociability, significantly decreased after intervention (p < 0.05). These findings suggest that Taekwondo training can not only improve flexibility among physical fitness factors, but can also be effective in improving the mood state and sociality of international students.
Effect of Postharvest Transport and Storage on Color and Firmness Quality of Tomato
Authors: Al-Dairi Mai , Pathare Pankaj B. , Al-Yahyai Rashid
Published: June 2021

Transport duration affects the vibration level generated which has adverse effects on fresh produce during transportation. Furthermore, temperature affects the quality of fresh commodities during storage. This study evaluated physical changes in tomatoes during transportation and storage. Tomatoes were transported at three distances (100, 154, and 205 km) from a local farm and delivered to the Postharvest Laboratory where vibration acceleration was recorded per distance. Tomato was stored at two different temperatures (10 °C and 22 °C) for 12 days. The physical qualities like weight loss and firmness of all tomato samples were evaluated. RGB image acquisition system was used to assess the color change of tomato. The results of vibration showed that over 40% of accelerations occurred in the range of 0.82–1.31 cm/s2 of all transport distances. Physical quality analyses like weight loss and firmness were highly affected by transportation distance, storage temperature, and storage period. The reduction in weight loss and firmness was the highest in tomatoes transported from the farthest distance and stored at 22 °C. Lightness, yellowness, and hue values showed a high reduction as transport distance increased particularly in tomatoes stored at 22 °C. Redness, total color difference, and color indices increased significantly on tomatoes transported from 205 km and stored at 10 °C and 22 °C. The study indicated that the increase in transportation distance and storage temperature cause higher changes in the physical qualities of tomatoes.
Water Infiltration after Prescribed Fire and Soil Mulching with Fern in Mediterranean Forests
Authors: Carrà Bruno Gianmarco , Bombino Giuseppe , Denisi Pietro , Plaza-Àlvarez Pedro Antonio , Lucas-Borja Manuel Esteban , Zema Demetrio Antonio
Published: June 2021

Prescribed fire is commonly used to reduce the wildfire risk in Mediterranean forests, but the soil’s hydrological response after fire is contrasting in literature experiences. The mulch treatment can limit the increases in runoff and erosion in the short term after a fire. The use of fern is preferable to straw, due its large availability in forests. However, no experiences of post-fire treatment with fern mulch have been found in the literature and therefore the mulching effectiveness has not been evaluated. This study has measured water infiltration rate (IR) and water repellency (SWR) using a rainfall simulator in three Mediterranean forest stands (pine, oak and chestnut) of Calabria (Southern Italy) after a prescribed fire and mulching treatment with fern in comparison to unburned soil. Prescribed fire reduced water infiltration in all forests in the short term compared to the unburned conditions, and increased SWR in pine and oak forests. These reductions in IR in the time window of disturbance after fire increased the runoff generation capacity in all soils, but had a lower effect on peak flows. However, soil mulching with fern limited the runoff rates and peak flows compared to the burned soils, but this treatment was less effective in pine forest. One year after fire, IR increased in burned soils (treated or not) over time, and SWR disappeared. The effects of mulching have disappeared after some months from fire. The study confirms the usefulness of mulching in broadleaves forest in the short term, in order to control the hydrological effects of prescribed fire in Mediterranean forests. Both post-fire management techniques should be instead adopted with caution in conifer forests.
Assessing the Functional Status of Patients with Chronic Pain—Cross Cultural Adaptation and Psychometric Properties of the Serbian Version of the Pain Disability Questionnaire
Authors: Knežević Aleksandar , Čolović Petar , Jeremić-Knežević Milica , Demeši-Drljan Čila , Simić-Panić Dušica , Neblett Randy
Published: June 2021

The Pain Disability Questionnaire (PDQ) has established itself as a leading patient-reported outcome measure for assessing both mental and physical components of pain-related disability. The current study aimed to translate the PDQ into Serbian and validate its psychometric properties. Following a standard translation process, a total of 554 chronic pain patients (average age 55.37 ± 12.72 years; 375 (67.5%) females) completed the PDQ-Serb, Oswestry Disability Index (ODI), Short Form-36 (SF-36), pain intensity rating and a six-minute walk test (6MWT). Responsiveness was examined in a subsample of 141 patients who completed an inpatient rehabilitation program. The internal consistency of the PDQ-Serb was excellent (Cronbach α = 0.92) and test-retest reliability was favorable (ICC = 0.87). Factor analyses found a bifactor model to be the best fit (CFI = 0.97: TLI = 0.96: RMSEA = 0.05; SRMR = 0.03). Statistically significant Pearson’s coefficient correlations (p < 0.001) were found between the PDQ-Serb and ODI (r = 0.786), SF-36 Physical Components summary (r = −0.659), SF-36 Mental Components summary (r = −0.493), pain intensity rating (r = 0.572), and 6MWT (r = −0.571). Significant post-treatment improvements following inpatient rehabilitation were found with the PDQ-Serb (p < 0.001; effect size 0.431) and other clinical variables (p < 0.001; effect sizes from 0.367 to 0.536). The PDQ-Serb was shown to be a reliable and valid self-report instrument for the evaluation of pain-related disability.
Understanding the Drivers of Mobility during the COVID-19 Pandemic in Florida, USA Using a Machine Learning Approach
Authors: Zhu Guimin , Stewart Kathleen , Niemeier Deb , Fan Junchuan
Published: June 2021

As of March 2021, the State of Florida, U.S.A. had accounted for approximately 6.67% of total COVID-19 (SARS-CoV-2 coronavirus disease) cases in the U.S. The main objective of this research is to analyze mobility patterns during a three month period in summer 2020, when COVID-19 case numbers were very high for three Florida counties, Miami-Dade, Broward, and Palm Beach counties. To investigate patterns, as well as drivers, related to changes in mobility across the tri-county region, a random forest regression model was built using sociodemographic, travel, and built environment factors, as well as COVID-19 positive case data. Mobility patterns declined in each county when new COVID-19 infections began to rise, beginning in mid-June 2020. While the mean number of bar and restaurant visits was lower overall due to closures, analysis showed that these visits remained a top factor that impacted mobility for all three counties, even with a rise in cases. Our modeling results suggest that there were mobility pattern differences between counties with respect to factors relating, for example, to race and ethnicity (different population groups factored differently in each county), as well as social distancing or travel-related factors (e.g., staying at home behaviors) over the two time periods prior to and after the spike of COVID-19 cases.
Current Perspectives on Neonatal Screening for Propionic Acidemia in Japan: An Unexpectedly High Incidence of Patients with Mild Disease Caused by a Common PCCB Variant
Authors: Tajima Go , Kagawa Reiko , Sakura Fumiaki , Nakamura-Utsunomiya Akari , Hara Keiichi , Yuasa Miori , Hasegawa Yuki , Sasai Hideo , Okada Satoshi
Published: June 2021

Propionic acidemia (PA) is a disorder of organic acid metabolism which typically presents with acute encephalopathy-like symptoms associated with metabolic acidosis and hyperammonemia during the neonatal period. The estimated incidence of symptomatic PA in Japan is 1/400,000. The introduction of neonatal screening using tandem mass spectrometry has revealed a far higher disease frequency of approximately 1/45,000 live births due to a prevalent variant of c.1304T>C (p.Y435C) in PCCB, which codes β-subunit of propionyl-CoA carboxylase. Our questionnaire-based follow-up study reveals that most of these patients remain asymptomatic. However, reports on symptomatic patients exhibiting cardiac complications such as cardiomyopathy and QT prolongation have been increasing. Moreover, there were even cases in which these cardiac complications were the only symptoms related to PA. A currently ongoing study is investigating the risk of cardiac complications in patients with neonatal screening-detected PA caused by this common variant.
Experimental Investigation of the Unsteady Stator/Rotor Wake Characteristics Downstream of an Axial Air Turbine
Authors: Duda Daniel , Jelínek Tomáš , Milčák Petr , Němec Martin , Uruba Václav , Yanovych Vitalii , Žitek Pavel
Published: June 2021

A feasibility study of velocity field measurements using the Particle Image Velocimetry (PIV) method in an axial air turbine model is presented. The wakes past the blades of the rotor wheel were observed using the PIV technique. Data acquisition was synchronized with the shaft rotation; thus, the wakes were phase averaged for statistical analysis. The interaction of the rotor blade wakes with the stator ones was investigated by changing the stator wheel’s angle. The measurement planes were located just behind the rotor blades, covering approximately 3 cm × 3 cm in axial × tangential directions. The spatial correlation function suggests that the resolution used is sufficient for the large-scale flow-patterns only, but not for the small ones. The scales of fluctuations correspond to the shear layer thickness at the mid-span plane but, close to the end-wall, they contain larger structures caused by the secondary flows. The length-scales of the fluctuations under off-design conditions display a dependence on the area of the stator and rotor wakes cross-sections, which, in turn, depend on their angle. The obtained experimental data are to be used for the validation of mathematical simulation results in the future.
Biological Control of Pest Non-Marine Molluscs: A Pacific Perspective on Risks to Non-Target Organisms
Authors: Christensen Carl C. , Cowie Robert H. , Yeung Norine W. , Hayes Kenneth A.
Published: June 2021

Classic biological control of pest non-marine molluscs has a long history of disastrous outcomes, and despite claims to the contrary, few advances have been made to ensure that contemporary biocontrol efforts targeting molluscs are safe and effective. For more than half a century, malacologists have warned of the dangers in applying practices developed in the field of insect biological control, where biocontrol agents are often highly host-specific, to the use of generalist predators and parasites against non-marine mollusc pests. Unfortunately, many of the lessons that should have been learned from these failed biocontrol programs have not been rigorously applied to contemporary efforts. Here, we briefly review the failures of past non-marine mollusc biocontrol efforts in the Pacific islands and their adverse environmental impacts that continue to reverberate across ecosystems. We highlight the fact that none of these past programs has ever been demonstrated to be effective against targeted species, and at least two (the snails Euglandina spp. and the flatworm Platydemus manokwari) are implicated in the extinction of hundreds of snail species endemic to Pacific islands. We also highlight other recent efforts, including the proposed use of sarcophagid flies and nematodes in the genus Phasmarhabditis, that clearly illustrate the false claims that past bad practices are not being repeated. We are not making the claim that biocontrol programs can never be safe and effective. Instead, we hope that in highlighting the need for robust controls, clear and measurable definitions of success, and a broader understanding of ecosystem level interactions within a rigorous scientific framework are all necessary before claims of success can be made by biocontrol advocates. Without such amendments to contemporary biocontrol programs, it will be impossible to avoid repeating the failures of non-marine mollusc biocontrol programs to date.
Discrimination between Eggs from Stink Bugs Species in Europe Using MALDI-TOF MS
Authors: Reeve Michael A. , Haye Tim
Published: June 2021

In the current paper, we used a method based on stink bug egg-protein immobilization on filter paper by drying, followed by post-(storage and shipping) extraction in acidified acetonitrile containing matrix, to discriminate between nine different species using MALDI-TOF MS. We obtained 87 correct species-identifications in 87 blind tests using this method. With further processing of the unblinded data, the highest average Bruker score for each tested species was that of the cognate reference species, and the observed differences in average Bruker scores were generally large and the errors small except for Capocoris fuscispinus, Dolycoris baccarum, and Graphosoma italicum, where the average scores were lower and the errors higher relative to the remaining comparisons. While we observed clear discrimination between the nine species using this method, Halyomorpha halys and Piezodorus lituratus were more spectrally related than the other pairwise comparisons.
Multi-Criteria Analysis of the Mass Tourism Management Model Related to the Impact on the Local Community in Constanta City (Romania)
Authors: Anton Catalin , Micu Angela-Eliza , Rusu Eugen
Published: June 2021

Traditionally and socially, the tourism in Constanta is considered to be important to the local economy. Sun and beach locations are both a draw for locals and tourists to the city, on the Black Sea. However, vacation-oriented activities in the city only have a seasonal cycle. In this paper, we proposed to analyze the mass tourist activity in Constanta, taking into account economic, social, and environmental conditions. Additionally, we attempted to build a model based on the data available. The model was developed using a PESTEL analysis to determine the supportability factor of the indicators identified. We also set out to create a projection of the activities proposed for analysis by 2050. To create a model for coastal areas, the data used in this research must be accurate and consistent. Furthermore, correctly identifying indicators and their relationships is a critical step in conducting a thorough study. Last but not least, finding the calculation coefficient for the activity in question is critical, as collecting data from various activities might be challenging when trying to find a feasible model.
Attacks and Defenses for Single-Stage Residue Number System PRNGs
Authors: Vennos Amy , George Kiernan , Michaels Alan
Published: June 2021

This paper explores the security of a single-stage residue number system (RNS) pseudorandom number generator (PRNG), which has previously been shown to provide extremely high-quality outputs when evaluated through available RNG statistical test suites or in using Shannon and single-stage Kolmogorov entropy metrics. In contrast, rather than blindly performing statistical analyses on the outputs of the single-stage RNS PRNG, this paper provides both white box and black box analyses that facilitate reverse engineering of the underlying RNS number generation algorithm to obtain the residues, or equivalently key, of the RNS algorithm. We develop and demonstrate a conditional entropy analysis that permits extraction of the key given a priori knowledge of state transitions as well as reverse engineering of the RNS PRNG algorithm and parameters (but not the key) in problems where the multiplicative RNS characteristic is too large to obtain a priori state transitions. We then discuss multiple defenses and perturbations for the RNS system that fool the original attack algorithm, including deliberate noise injection and code hopping. We present a modification to the algorithm that accounts for deliberate noise, but rapidly increases the search space and complexity. Lastly, we discuss memory requirements and time required for the attacker and defender to maintain these defenses.
Sex Differences in Characteristics and Outcomes among Low-Risk Non-ST-Elevation Acute Coronary Syndrome Patients during Long Term Follow-Up
Authors: Kristić Ivica , Matetic Andrija , Crnčević Nikola , Runjić Frane , Polašek Ozren , Vrsalovic Mislav
Published: June 2021

Previous heterogenous studies show conflicting data about sex-based outcomes of non-ST-elevation acute coronary syndrome (NSTE-ACS) patients. This study evaluated 300 NSTE-ACS patients undergoing a coronary angiography between September 2012 and May 2015 that were managed with all-treatment strategies. The sample was stratified by sex and analyzed for the baseline characteristics and outcomes. The main outcome included major adverse cardiovascular and cerebrovascular events (MACCE), which were a composite of cardiac death, nonfatal myocardial infarction, ischemic stroke or urgent coronary revascularization. The female patients were older (median of 69.0 vs. 63.0 years, p = 0.008) and had lower values of BMI (median of 26.3 vs. 28.2 kg/m2, p < 0.001) and eGFR (76.44 ± 22.43 vs. 94.04 ± 27.91 mL/min, p < 0.001). There was no significant difference in the treatment strategies, angiographic characteristics and discharge therapy between the groups (p > 0.05). The female patients had significantly higher unadjusted rates of ischemic stroke (4.2% vs. 0.5%, p = 0.023), cardiac mortality (11.3%, vs. 3.9%, p = 0.022) and MACCE (33.8%, vs. 19.5%, p = 0.014); female sex was a significant predictor of MACCE in the univariate analysis (HR 1.86, 95%CI 1.12–3.09, p = 0.014); and the cumulative incidence of MACCE was higher in female patients (p = 0.014). After the adjustment, the predictive effect of female sex became non-significant (HR 1.60, 95%CI 0.94–2.73, p = 0.083), while there was no difference in the cumulative incidence of MACCE among the propensity score matched cohort (p = 0.177). Female NSTE-ACS patients have worse long-term outcomes compared to their male counterparts. However, the differences disappear after adjustment and propensity score matching. Continuing efforts and health measures are required to alleviate any sex-based differences in the NSTE-ACS population.
Changes in Left Ventricular Ejection Fraction after Mitral Valve Repair for Primary Mitral Regurgitation
Authors: Joung Kyoung-Woon , Kim Seon-Ok , Nam Jae-Sik , Moon Young-Jin , Bae Hyeun-Joon , Chin Ji-Hyun , Jung Sung-Ho , Choi In-Cheol
Published: June 2021

This study sought to identify the short- and long-term changes in left ventricular ejection fraction (LVEF) after mitral valve repair (MVr) in patients with chronic primary mitral regurgitation according to preoperative LVEF (pre-LVEF) and preoperative left ventricular end-systolic diameter (pre-LVESD). This study evaluated 461 patients. Restricted cubic spline regression models were constructed to demonstrate the long-term changes in postoperative LVEF (post-LVEF). The patients were divided into four groups according to pre-LVEF (<50%, 50–60%, 60–70%, and ≥70%). The higher the pre-LVEF was, the greater was the decrease in LVEF immediately after MVr. In the same pre-LVEF range, immediate post-LVEF was lower in patients with pre-LVESD ≥ 40 mm than in those with pre-LVESD < 40 mm. The patterns of long-term changes in post-LVEF differed according to pre-LVEF (p for interaction < 0.001). The long-term post-LVEF reached a plateau of approximately 60% when the pre-LVEF was ≥50%, but it seemed to show a downward trend after reaching a peak at approximately 3–4 years after MVr when the pre-LVEF was ≥70%. The patterns of short- and long-term changes in post-LVEF differed according to pre-LVEF and pre-LVESD values in patients with chronic primary mitral regurgitation after MVr.
Levels of Biological Markers of Nitric Oxide in Serum of Patients with Mandible Fractures
Authors: Wozniak Lukasz , Ratajczak-Wrona Wioletta , Borys Jan , Antonowicz Bozena , Nowak Karolina , Bortnik Piotr , Jablonska Ewa
Published: June 2021

Background: Nitric oxide is a small gaseous molecule with significant bioactivity. It has been observed that NO may have a dual role dependent on its production and concentrations in the bone microenvironment. The objective of the study was to assess the concentration of total nitric oxide malonyldialdehyde, nitrotyrosine, and asymmetric dimethylarginine in the serum of patients with mandibular fractures and to understand the relationship between these compounds, in order to expand the knowledge base of the role of nitric oxide and its activity indicators in the process of bone fracture healing. Material and Methods: The study included 20 patients with mandibular fractures who were undergoing inpatient and outpatient treatments and a control group of 15 healthy people. Results were analyzed with respect to the measurement time. Total nitric oxide concentration in the blood serum was determined according to the Griess reaction, while the concentration of malonyldialdehyde, nitrotyrosine, and asymmetric dimethylarginine was estimated using the immunoenzymatic method (i.e., enzyme-linked immunosorbent assay). Results: Before the procedure, as well as on the first day and 2 and 6 weeks after the procedure, higher concentrations of total nitric oxide and lower concentrations of malonyldialdehyde were observed in the blood serum of patients with mandibular fractures compared to the control group. No statistically significant differences were found in nitrotyrosine concentrations in the blood serum of patients throughout the measurement period. However, a significantly higher asymmetric dimethylarginine concentration was observed in the patient serum before the procedure and on the first day of operation as compared with the control group. Analysis of the results observed in patient serum with respect to the number of fractures within the mandible demonstrated the same trend of concentrations for the tested compounds for the entire study group. Conclusions: In summary, our results revealed that the intensity of local processes resulting from mandibular fractures is associated with the concentration of nitric oxide, confirming its significant role, as well as that of its indicators, in the process of bone fracture healing in this patient population.
Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis
Authors: Ptaszek Bartłomiej , Teległów Aneta , Adamiak Justyna , Głodzik Jacek , Podsiadło Szymon , Mucha Dawid , Marchewka Jakub , Halski Tomasz , Mucha Dariusz
Published: June 2021

The aim of this study was to examine and assess the impact of a series of 20 whole-body cryotherapy (WBC) treatments on the biochemical and rheological indices of blood in people with multiple sclerosis. In this prospective controlled study, the experimental group consisted of 15 women aged 34–55 (mean age, 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent a series of whole-body cryotherapy treatments. The first control group consisted of 20 women with diagnosed multiple sclerosis. This group had no intervention in the form of whole-body cryotherapy. The second control group consisted of 15 women aged 30–49 years (mean age, 38.47 ± 6.0 years) without neurological diseases and other chronic diseases who also underwent the whole-body cryotherapy treatment. For the analysis of the blood indices, venous blood was taken twice (first, on the day of initiation of whole-body cryotherapy treatments and, second, after a series of 20 cryotherapy treatments). The blood counts were determined using an ABX MICROS 60 hematological analyzer (USA). The LORCA analyzer (Laser–Optical Rotational Cell Analyzer, RR Mechatronics, the Netherlands) was used to study the aggregation and deformability of erythrocytes. The total protein serum measurement was performed using a Cobas 6000 analyzer, Roche and a Proteinogram-Minicap Sebia analyzer. Fibrinogen determinations were made using a Bio-Ksel, Chrom-7 camera. Statistically significant differences and changes after WBC in the levels of red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), elongation index, total extend of aggregation (AMP), and proteins (including fibrinogen) were observed. However, there was no significant effect of a series of 20 WBC treatments on changes in blood counts, rheology, and biochemistry in women with multiple sclerosis. Our results show that the use of WBC has a positive effect on the rheological properties of the blood of healthy women.
Levels of Produced Antibodies after Vaccination with mRNA Vaccine; Effect of Previous Infection with SARS-CoV-2
Authors: Konstantinidis Theocharis G. , Zisaki Stavroula , Mitroulis Ioannis , Konstantinidou Eleni , Kontekaki Eftychia G. , Romanidou Gioulia , Karvelas Alexandros , Nanousi Ioanna , Lazidis Leonidas , Cassimos Dimitrios , Tsigalou Christina , Martinis Georges , Panopoulou Maria
Published: June 2021

The aim of this study was to estimate the immunogenic effect of mRNA vaccine against SARS-CoV-2. This study included 510 participants who received mRNA vaccine. The measurement of anti-COVID-19 antibodies was performed using the Abbott SARS-CoV-2 IgG quantitative assay (Abbott). Overall, mean titer of anti-Spike antibodies was 19,319.2 ± 1787.5 AU/mL. Vaccination induced a robust immunogenic response in those previously infected with SARS-CoV-2 compared with non-infected subjects. Additionally, individuals that were asymptomatic after vaccination produced lower levels of antibodies compared to feverish individuals. In conclusion, remarkably high levels of anti-Spike COVID-19 antibodies were observed after vaccination.
Axial Psoriatic Disease: Clinical and Imaging Assessment of an Underdiagnosed Condition
Authors: Giovannini Ivan , Zabotti Alen , Cicciò Carmelo , Salgarello Matteo , Cereser Lorenzo , De Vita Salvatore , Tinazzi Ilaria
Published: June 2021

The frequent involvement of the spine and sacroiliac joint has justified the classification of psoriatic arthritis (PsA) in the Spondyloarthritis group. Even if different classification criteria have been developed for PsA and Spondyloarthritis over the years, a well-defined distinction is still difficult. Although the majority of PsA patients present peripheral involvement, the axial involvement needs to be taken into account when considering disease management. Depending on the definition used, the prevalence of axial disease may vary from 25 to 70% in patients affected by PsA. To date, no consensus definition has been reached in the literature and the definition of axial involvement in PsA has varied from isolated sacroiliitis to criteria used in ankylosing spondylitis. This article reviews the unmet needs in the clinical and radiological assessment of axial PsA, reporting the various interpretations of axial involvement, which have changed over the years. Focusing on both imaging and clinical standpoints, we reported the prevalence of clinical and radiologic features, describing the characteristics of axial disease detectable by X-rays, magnetic resonance imaging, and PET-CT, and also describing the axial symptoms and outcome measures in patients affected by axial disease.
Gender Differences in the Medical Treatment of Peripheral Artery Disease
Authors: Lanéelle Damien , Sauvet Gabriella , Guillaumat Jérôme , Trihan Jean Eudes , Mahé Guillaume
Published: June 2021

Background/Objectives: Peripheral arterial disease is a frequent and severe disease with high cardiovascular morbidity and mortality. However, female patients appear to be undertreated. Objectives: The primary goal was to compare the prescription of optimal medical treatment (OMT) of peripheral arterial disease between women and men in primary health care. Material and methods: An observational retrospective study was based on the data collected from general practitioners (GP) office in Brittany. Results: The study included 100 patients, aged 71 ± 10 years old, with 24% of women. Compared to men, women received the OMT less frequently (29.2% vs. 53.9%, p = 0.038), especially after 75 years old. Antiplatelet therapy was largely prescribed (100%), statins less frequently (70.8% women vs. 85.5% men), and prescription of renin-angiotensin-aldosterone system inhibitors was still not optimal in the two genders (41.7% women vs. 61.9% men). Active smoking is important for both women and men (33% and 30% respectively). Conclusion: Optimal medical treatment of peripheral artery disease is insufficiently prescribed, especially in women in this region of France.
Many Good Reasons to Switch from Vitamin K Antagonists to Non-Vitamin K Antagonists in Patients with Non-Valvular Atrial Fibrillation
Authors: Botto Giovanni Luca , Ameri Pietro , De Caterina Raffaele
Published: June 2021

Non-vitamin K oral anticoagulants (NOACs) are the first choice for prophylaxis of cardioembolism in patients with non-valvular atrial fibrillation (AF) who are anticoagulant-naïve, as well as the preferable anticoagulation strategy in those who are on vitamin K antagonists (VKAs), but with a low time in therapeutic range (TTR). Nonetheless, there are many good reasons to consider switching from VKAs to NOACs also when TTR is >70%. From the pharmacological standpoint, anticoagulation with VKAs may remain erratic even in those patients who have high TTR values, owing to the mode of action of this drug class. Furthermore, experimental data suggest that, unlike VKAs, NOACs favorably modulate the effects of factor Xa and thrombin in the cardiovascular system through the protease-activated receptor family. Clinically, the most striking advantage provided by NOACs over VKAs, irrespective of the TTR, is the substantially lower risk of intracranial hemorrhage. NOACs have also been associated with less deterioration of renal function as compared with VKAs and may confer protection against cardiovascular events not strictly related to AF, especially the acute complications of peripheral artery disease. In this narrative review, we discuss the evidence according to which it is warranted to systematically substitute NOACs for VKAs for the prevention of AF-related stroke and systemic embolism.
Effects of Presurgical Mandibular Incisor Decompensation on Long-Term Outcomes of Class III Surgical Orthodontic Treatment
Authors: An Jung-Sub , Jeong Wonchae , Sonnesen Liselotte , Baek Seung-Hak , Ahn Sug-Joon
Published: June 2021

This research aimed to evaluate the effects of presurgical mandibular incisor decompensation on long-term outcomes of Class III surgical orthodontic treatment. Thirty-five patients with skeletal Class III malocclusion who received conventional surgical orthodontic treatment were included. Mandibular incisor brackets with −6° of inclination were placed normally in 18 patients (NB group) and inversely in 17 patients (RB group). Between-group differences and relationships between incisal and skeletal variables were analyzed based on lateral cephalograms at pretreatment, presurgery, postsurgery, posttreatment, and retention. Mandibular incisors were more labially inclined in the RB group than in the NB group from presurgery to retention. No significant between-group differences were observed in presurgical and postsurgical skeletal relationships. The NB group exhibited a larger overjet with deficient interincisal contact at postsurgery than the RB group. Skeletal Class III relationship was also more severe in the NB group at retention. More lingually inclined mandibular incisors at presurgery and larger overjet at postsurgery were correlated with a more severe skeletal Class III relationship at retention. Thus, establishing appropriate postsurgical overjet by sufficient presurgical mandibular incisor decompensation may play a significant role in postsurgical stability of Class III surgical orthodontic treatment.
Transcranial Magnetic Stimulation as a Diagnostic and Therapeutic Tool in Various Types of Dementia
Authors: Antczak Jakub , Rusin Gabriela , Słowik Agnieszka
Published: June 2021

Dementia is recognized as a healthcare and social burden and remains challenging in terms of proper diagnosis and treatment. Transcranial magnetic stimulation (TMS) is a diagnostic and therapeutic tool in various neurological diseases that noninvasively investigates cortical excitability and connectivity and can induce brain plasticity. This article reviews findings on TMS in common dementia types as well as therapeutic results. Alzheimer’s disease (AD) is characterized by increased cortical excitability and reduced cortical inhibition, especially as mediated by cholinergic neurons and as documented by impairment of short latency inhibition (SAI). In vascular dementia, excitability is also increased. SAI may have various outcomes, which probably reflects its frequent overlap with AD. Dementia with Lewy bodies (DLB) is associated with SAI decrease. Motor cortical excitability is usually normal, reflecting the lack of corticospinal tract involvement. DLB and other dementia types are also characterized by impairment of short interval intracortical inhibition. In frontotemporal dementia, cortical excitability is increased, but SAI is normal. Repetitive transcranial magnetic stimulation has the potential to improve cognitive function. It has been extensively studied in AD, showing promising results after multisite stimulation. TMS with electroencephalography recording opens new possibilities for improving diagnostic accuracy; however, more studies are needed to support the existing data.
Numerical Study of Soil-Thawing Effect of Composite Piles Using GMsFEM
Authors: Sivtsev Petr V. , Smarzewski Piotr , Stepanov Sergey P.
Published: June 2021

During construction works, it is advisable to prevent strong thawing and an increase in the moisture content of the foundations of engineering structures in the summer. Since the density of water and ice differ, due to the difference bulging of the foundation sections can occur when it freezes back in winter. In this work, the effect of fiber-reinforced piles on the thermal field of the surrounding soil is investigated numerically; that is, the study of the influence of aggregates with high and low thermal-physical properties on the temperature of frozen soils is conducted. Basalt and steel fiber reinforcement are compared. The difficulty of this work is that the inclusions inside piles are too small compared to the pile itself. Therefore, to solve the Stefan problem, a generalized multiscale finite element method (GMsFEM) was used. In the GMsFEM, the usual conforming partition of the domain into a coarse grid was used. It allowed reducing problem size and, consequently, accelerating the calculations. Results of the multiscale solution were compared with fine-scale solution, the accuracy of GMsFEM was investigated, and the optimal solution parameters were defined. Therefore, GMsFEM was shown to be well suited for the designated task. Collation of basalt and steel fiber reinforcement showed a beneficial effect of high thermal conductive material inclusion on freezing of piles in winter.
Structure and Mechanical Properties of Laser Powder Bed-Fused and Wrought PH13-8Mo-Type Precipitation Hardening Stainless Steels: Comparative Study
Authors: Turnier Trottier William , Kreitcberg Alena , Brailovski Vladimir
Published: June 2021

This work focuses on the structure and properties of a laser powder bed-fused (LPBF) precipitation hardening stainless steel and its chemically analogous wrought counterpart, both subjected to an identical combination of solution and aging treatments with the objective of maximizing the material hardness. It was observed that both the LPBF and wrought alloy follows similar evolution of their phase composition, microstructure, and mechanical properties throughout the different stages of the technological workflow. After a solution treatment at 850 °C for 0.5 h and an aging at 525 °C for 2 h, both alloys achieve their highest hardness of ~50 HRC. Notwithstanding this similarity, the LPBF alloy offers a finer microstructure and a lower amount of retained austenite than its wrought counterpart. This microstructure provides comparable strength characteristics to both the LPBF and wrought alloys, while offering a significantly higher ductility to the former as compared to the latter. The elongation at break of the LPBF alloy is, however, strongly build orientation-dependent, with a measured anisotropy of 23%. This anisotropy is caused by the presence of processing-induced pores (average pore size ~23 µm) in the LPBF alloy preferably distributed in planes oriented perpendicular to the build direction.
The Impact of Fortnightly Stratification Variability on the Generation of Baroclinic Tides in the Luzon Strait
Authors: Zhang Zheen , Chen Xueen , Pohlmann Thomas
Published: June 2021

The impact of fortnightly stratification variability induced by tide–topography interaction on the generation of baroclinic tides in the Luzon Strait is numerically investigated using the MIT general circulation model. The simulation shows that advection of buoyancy by baroclinic flows results in daily oscillations and a fortnightly variability in the stratification at the main generation site of internal tides. As the stratification for the whole Luzon Strait is periodically redistributed by these flows, the energy analysis indicates that the fortnightly stratification variability can significantly affect the energy transfer between barotropic and baroclinic tides. Due to this effect on stratification variability by the baroclinic flows, the phases of baroclinic potential energy variability do not match the phase of barotropic forcing in the fortnight time scale. This phenomenon leads to the fact that the maximum baroclinic tides may not be generated during the maximum barotropic forcing. Therefore, a significant impact of stratification variability on the generation of baroclinic tides is demonstrated by our modeling study, which suggests a lead–lag relation between barotropic tidal forcing and maximum baroclinic response in the Luzon Strait within the fortnightly tidal cycle.
Solid-Fluid Coupled Numerical Analysis of Suction Caisson Installation in Sand
Authors: Wang He , Wang Rui , Zhang Jian-Min
Published: June 2021

Suction caissons are widely used foundations in offshore engineering. The change in excess pore pressure and seepage field caused by penetration and suction significantly affects the soil resistance around the caisson wall and tip, and also affects the deformation of the soil within and adjacent to the caisson. This study uses Arbitrary Lagrangian–Eulerian (ALE) large deformation solid-fluid coupled FEM to investigate the changes in suction pressure and the seepage field during the process of the suction caisson installation in sand. A nonlinear Drucker-Prager model is used to model soil, while Coulomb friction is applied at the soil-caisson interface. The ALE solid-fluid coupled FEM is shown to be able to successfully simulate both jacked penetration and suction penetration caisson installation processes in sand observed in centrifuge tests. The difference in penetration resistance for jacked and suction installation is found to be caused by the seepage and excess pore pressure generated during the suction caisson installation, highlighting the importance of using solid-fluid coupled effective stress-based analysis to consider seepage in the evaluation of suction caisson penetration.
Coastal Morphology Assessment and Coastal Protection
Authors: Yamamoto Yoshimichi
Published: June 2021

Sediment-collecting in rivers and seas to secure a large amount of aggregate reduces the supply of earth and sand to coasts [...]
Making Traditional Japanese Distilled Liquor, Shochu and Awamori, and the Contribution of White and Black Koji Fungi
Authors: Hayashi Kei , Kajiwara Yasuhiro , Futagami Taiki , Goto Masatoshi , Takashita Hideharu
Published: June 2021

The traditional Japanese single distilled liquor, which uses koji and yeast with designated ingredients, is called “honkaku shochu.” It is made using local agricultural products and has several types, including barley shochu, sweet potato shochu, rice shochu, and buckwheat shochu. In the case of honkaku shochu, black koji fungus (Aspergillus luchuensis) or white koji fungus (Aspergillus luchuensis mut. kawachii) is used to (1) saccharify the starch contained in the ingredients, (2) produce citric acid to prevent microbial spoilage, and (3) give the liquor its unique flavor. In order to make delicious shochu, when cultivating koji fungus during the shochu production process, we use a unique temperature control method to ensure that these three important elements, which greatly affect the taste of the produced liquor, are balanced without any excess or deficiency. This review describes in detail the production method of honkaku shochu, a distilled spirit unique to Japan and whose market is expected to expand worldwide, with special attention paid to the koji fungi cultivation step. Furthermore, we describe the history of the koji fungi used today in the production of shochu, and we provide a thorough explanation of the characteristics of each koji fungi. We also report the latest research progress on this topic.
Machine Learning-Based Approach Highlights the Use of a Genomic Variant Profile for Precision Medicine in Ovarian Failure
Authors: Henarejos-Castillo Ismael , Aleman Alejandro , Martinez-Montoro Begoña , Gracia-Aznárez Francisco Javier , Sebastian-Leon Patricia , Romeu Monica , Remohi Jose , Patiño-Garcia Ana , Royo Pedro , Alkorta-Aranburu Gorka , Diaz-Gimeno Patricia
Published: June 2021

Ovarian failure (OF) is a common cause of infertility usually diagnosed as idiopathic, with genetic causes accounting for 10–25% of cases. Whole-exome sequencing (WES) may enable identifying contributing genes and variant profiles to stratify the population into subtypes of OF. This study sought to identify a blood-based gene variant profile using accumulation of rare variants to promote precision medicine in fertility preservation programs. A case–control (n = 118, n = 32, respectively) WES study was performed in which only non-synonymous rare variants <5% minor allele frequency (MAF; in the IGSR) and coverage ≥ 100× were considered. A profile of 66 variants of uncertain significance was used for training an unsupervised machine learning model to separate cases from controls (97.2% sensitivity, 99.2% specificity) and stratify the population into two subtypes of OF (A and B) (93.31% sensitivity, 96.67% specificity). Model testing within the IGSR female population predicted 0.5% of women as subtype A and 2.4% as subtype B. This is the first study linking OF to the accumulation of rare variants and generates a new potential taxonomy supporting application of this approach for precision medicine in fertility preservation.