bluuebunny/crossref_metadata_2025 huggingface dataset:
Les Formes des Démarches Qualité dans les Collectivités Locales Marocaines
Authors: Sbaiss Larbi , Mbarki Mohamed Amine
Published: February 2023

Dans cet article nous cherchons à mettre en exergue les formes que prennent les démarches qualité dans la sphère publique marocaine. Il s’agit d’un essai de retour à la littérature de l’histoire des réformes et de la gestion locale, afin d’identifier les formes que les décideurs et les dirigeants marocains donnent aux projets d’amélioration de la qualité des services au sein des administrations locales. Ce travail s’inscrit dans le cadre de notre thèse de recherche sur les démarches qualité dans les collectivités locales marocaine avec un focus sur les communes urbaines. Il s’agit également d’apporter un éclairage sur le fait que les démarches qualité ne se limitent pas uniquement aux séries des normes ISO, à la gestion de la qualité totale ou aux autres référentiels, mais au contraire, les démarches qualité comprennent toutes les approches, les pratiques, les outils qui visent l’amélioration continue de la qualité de service. Par conséquent, nous admettons que toute initiative qui s’inscrit dans cette optique est considérée comme une démarche qualité. Toutes les formes de démarches qualité identifiées au sein des collectivités locales marocaines, ne font pas référence aux normes ISO, ces dernières sont connues comme les démarches les plus sollicitées par les dirigeants des organismes. Ce constat a fait l’objet d’une recherche longitudinale que nous avons menée dans ce type d’administrations publiques.
Influencia del Comercio Electrónico en la Internacionalización del Sector Asociativo de la Provincia de El Oro
Authors: Zaruma Kevin Stalin Suárez , Faicán Jean Pierre Izurieta , Luzuriaga Francisco Vladimir Benítez
Published: February 2023

El comercio electrónico es una herramienta virtual que permite el cambio en la manera de ofrecer productos y servicios, llevándolos a comercializar mediante plataformas digitales. Dentro del sector asociativo es importante la utilización del ecommerce puesto que es una herramienta que funciona de manera precisa para la internacionalización de las asociaciones de la provincia del Oro. Esta investigación tiene como objetivo principal determinar cómo influye el comercio electrónico en la internacionalización del sector asociativo de la provincia de El Oro. El enfoque de la investigación es cuantitativo con alcance descriptivo, realizando una encuesta a personas de diversas asociaciones del sector. Se utilizó el método Histórico-lógico para determinar la evolución del comercio electrónico. Finalmente se concluyó que existe una pequeña brecha entre las nuevas formas de comercialización que poco a poco se va acortando.
La función del vals en Valses y otras falsas confesiones (1972) de Blanca Varela
Authors: Fernández Cozman Camilo Rubén
Published: February 2023

El vals criollo es un género musical que se practica en el Perú desde finales del siglo XIX y tiene una función importante en Valses y otras falsas confesiones (1972), de la poeta peruana Blanca Varela, integrante de la denominada generación del cincuenta. Sobre la base del concepto de desmitificación (planteado por Umberto Eco) y del marco teórico de la Retórica General Textual de Stefano Arduini, se analizan algunos poemas representativos de Valses y otras falsas confesiones. Nuestro propósito central es plantear que, para Varela, hay dos tipos de vals: el criollo y el que defiende a los grupos marginales. Varela desmitifica el vals criollo y, a la vez, formula otra clase de vals que toma partido por los grupos periféricos.
La belleza decadente y el ultrametalero: un breve análisis de las influencias literarias e ideológicas de las letras de Parabellum
Authors: Bedoya Cely Andrés Felipe
Published: February 2023

En este artículo se analizarán cuatro canciones de Parabellum (“Madre muerte”, “Bruja maldita”, “666 engendro” y “Guerra, monopolio, sexo”) a partir de un enfoque basado en tres temas: la relación entre Parabellum y la poesía moderna, su crítica a la sociedad y su visión respecto de la violencia. Los postulados de Hugo Friedrich son un referente teórico importante, ya que hay relaciones entre la poética propuesta por los ultrametaleros de Parabellum y el estilo de la lírica moderna. Además, serán pertinentes algunas citas sobre Baudelaire y Nietzsche, esto con la intención de analizar las particularidades ideológicas de Parabellum. Esta banda representa una época de excesiva violencia, pero también al arte como un eslabón que posibilita afirmar la vida, en esta ocasión, por medio de la figura del ultrametalero. Parabellum, a partir de la belleza decadente, es una banda que refleja un posible escape de la realidad vacua, pero también una liberación.
“Soy canción que se fue/ de jonrón”. Traslación, performance y archivo en los videopoemas de Legna Rodríguez Iglesias
Authors: Garbatzky Irina
Published: February 2023

En concordancia con varias tendencias contemporáneas ya señaladas por la crítica (Laddaga 2009, Bourriaud 2009, Groys 2014), la escritura de Legna Rodríguez Iglesias puede leerse como una performance continua entre distintos géneros literarios y artísticos, soportes intermediales y audiovisuales. Sin embargo su condición traslaticia construye una poética original en tanto reutiliza formas anacrónicas del archivo y el repertorio latinoamericano (Taylor, 2015), -fundamentalmente las que se fundan en una voz narradora-, para construir una escritura femenina y migrante. En sus videopoemas observamos la recuperación de una poesía rimada, de tradición oral; así como determinados temas y formatos que recuperan y desarman motivos clásicos de la literatura cubana, en los que resuena la figura de José Martí: los tonos de una literatura para los niños y niñas de América y las raíces portátiles de una poeta en la gran ciudad.
Monitoring of incomes and living standards of the population of Russia – 2021 : [monograph]. Issue 5 (201)
Authors:   Institute of Economics RAS, Moscow, Russia, Bobkov Vyacheslav N. , Odintsova Elena V. ,   Institute of Economics RAS, Moscow, Russia, Chernykh Ekaterina A. ,   Institute of Economics RAS, Moscow, Russia
Published: February 2023

Представленная монография является составной частью госзадания по теме «Основы экономического поведения и благосостояния населения: мотивы, факторы, ожидания» (ЕГИСУ: 122031600479-1, FMUS-2022-0017). Результаты мониторинга доходов и уровня жизни населения России издаются с 1995 г.: в период 1995-2015 гг. – во Всероссийском центре уровня жизни, с 2018 г. – в Институте социально-экономических проблем народонаселения Российской академии наук, с 2019 г. – в Институте социальноэкономических проблем народонаселения Федерального научно-исследовательского социологического центра Российской академии наук (ИСЭПН ФНИСЦ РАН). По итогам мониторинга актуализируется база данных РИД «Мониторинг доходов и уровня жизни населения России», зарегистрированная Федеральной службой по интеллектуальной собственности, номер регистрации (свидетельства) 2021621841.
Azerbaycan Türkçesine Göre Eski Anadolu Türkçesi Metinlerinde Kapalı e Sesi
Authors: AKGÜL Semra
Published: February 2023

Türkçede sekiz ünlü sesin yanında bir kapalı e (ė) sesinin var olduğu düşünülmüş, ancak Türklerin tarih boyunca kullandıkları alfabe sistemlerinde kapalı e sesi için müstakil işaretlerin kullanılmaması konuyu tartışmalı hale getirmiştir. Bazı metinlerde görülen özel işaretler veya aynı kelimenin ikili kullanımları bazı araştırmacılar için kapalı e sesinin varlığının kanıtı olarak kabul edilirken; bazı araştırmacılar içinse Türkçenin asli sesi olabilecek bir ünlü için net bir işaret kullanılmayıp bu denli çelişkili sonuçların doğması kapalı e sesinin varlığının reddine dayanak olarak sunulmuştur. Bu çalışmanın konusu kapalı e sesinin bu sesi canlı bir şekilde yaşatan Azerbaycan Türkçesi ile Oğuz grubunun tarihî basamağı olan Eski Anadolu Türkçesi metinleri üzerinden karşılaştırılmasıdır.
"Lo que me nutre, me destruye" . Los Trastornos de la Conducta Alimentaria como expresiones de la violencia sexual contra las mujeres
Authors: Lips Larrañaga Macarena , Eridani Aleosha
Published: February 2023

En el presente ensayo realizamos una reflexión teórica y política en torno a los trastornos de la conducta alimentaria desde una perspectiva feminista, argumentando cómo éstos también pueden ser expresiones de la violencia sexual contra las mujeres. Abordamos dos fenómenos concretos, considerando la práctica de la cosificación del cuerpo de las mujeres. En primer lugar, las ‘dietas’, práctica socialmente aceptada, que proponemos aquí entender como una forma invisibilizada de violencia asociada a la autocosificación. En segundo lugar, la anorexia, trastorno que en ocasiones puede llevar a la muerte, muerte en torno a la cual proponemos realizar una reflexión vinculada con la categoría de feminicidio en un sentido amplio. El abordaje de ambos fenómenos busca abrir la discusión sobre los trastornos de la conducta alimentaria más allá de la medicina y la psicología, visibilizando las formas en que la violencia se oculta en las prácticas naturalizadas que incluso las propias mujeres ejercen sobre sí mismas en una sociedad cisheteropatriarcal.
Metformin, a “Wonder Drug”, Targets METC for Pulmonary Protection
Authors: ROS Editorial Office
Published: February 2023

Metformin, a widely used antidiabetic drug, possesses other beneficial activities, including cardiovascular protection, anti-tumorigenesis, antiaging, and weight control. This Cutting-Edge Research Highlights outlines some latest basic research discoveries on metformin’s suppression of mitochondrial electron transport chain (METC) in the intervention of pulmonary inflammatory disorders, including tuberculosis and acute respiratory distress syndrome in animal models. These novel discoveries further support metformin as a pleiotropic drug for treating diverse diseases.
(First online: February 19, 2023)
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The Corporate Attitude Regading the Impact of Artificial Intelligence in the Financial Sector
Authors:   Bucharest University of Economic Studies, Romania, MIHAI Mirela-Simina
Published: February 2023

The objective of this paper is to analyze if the financial sector is ready for implementation of Artificial Intelligencebased solutions through a qualitative study. The scope of this paper is to contribute to the spatiality literature by bringing in front of the reader a guide who comprises research of the most important elements of financial domain which will be impacted by the implementation of Artificial Intelligence-based solutions. The used research methodology is the qualitative analysis based on a structured interview, whose responses were analyzed using Grounded Theory. To the interview have answered 27 representatives of top Romanian companies, these representing only a beginning of future wider studies. After analyzing the answers, the author concluded that in the financial field solutions based on artificial intelligence can be implemented very easily because it involves a lot of repetitive tasks that can be easily carried out with the help of these solutions in a shorter time and with fewer errors. The number of jobs involving these repetitive activities will also be significantly reduced over the next ten years.
Implications of Financial Literacy on Entrepreneurship
Authors:   International School of Management, Frankfurt am Main, Germany, HAMMER Thomas , SIEGFRIED Patrick ,   International School of Management, Frankfurt am Main, Germany
Published: February 2023

Financial literacy is the focus of today’s scientific research and has attracted considerable attention. The research focused almost on measuring and interpreting the financial literacy of individuals and households. Research on the general financial literacy of entrepreneurs has so far been limited. Entrepreneurs are drivers of innovation and growth and their ability to make the right financial decisions requires financial literacy among entrepreneurs. The OECD has defined financial literacy of entrepreneurs as the combination of awareness, knowledge, skills, attitudes, and behavior that a potential entrepreneur or an owner or manager of a micro, small, or medium-sized enterprise should to make effective financial decisions to start a business, run a business and ultimately ensure its sustainability and growth. This defines the general need to understand whether entrepreneurs have the skills/abilities or are accessible to make “effective financial decisions”. Such decisions may concern the use of short and longterm capital of their enterprises, working capital and investment decisions, and access to finance for the latter, financing decisions (OECD, 2018). This paper examines the implications of financial literacy on entrepreneurship that emerge from contemporary research and provides approaches for further necessary research in this area.
Population pharmacokinetic-pharmacodynamic model of dexmedetomidine in elderly patients undergoing sedation after abdominal aortic surgery
Authors: Ber Justyna Alicja , Bienert Agnieszka , Sobczyński Paweł , Nowicka Małgorzata , Żurański Łukasz , Hołysz Marcin , Grześkowiak Edmund , Wiczling Paweł
Published: February 2023

Background. Dexmedetomidine (DEX) is a widely used sedative agent for treating post-surgery patients. It also acts on hemodynamic parameters like heart rate or cardiac output. This study aimed to develop a pharmacokinetic-pharmacodynamic (PK/PD) model of DEX using bispectral index (BIS) and cardiac output (CO) as a response.
Methodology and results. 21 mechanically ventilated elderly cardiac patients undergoing abdominal aortic surgery were enrolled in the study. DEX was given to maintain moderate or deep sedation. Genotypes of ADR2A*55 were identified using real-time PCR-HRM. Data were analyzed using nonlinear mixed-effect modelling. A two-compartment model described DEX pharmacokinetics. The sigmoid Emax and linear models were used to describe BIS and CO measurements. The typical value of EC50 for DEX effects on BIS was 3.62 ng/ml, and the slope between CO and DEX concentrations was 0.819 (L/min)/(ng/ml). We were unable to show the effects of considered covariates on DEX pharmacodynamics.
Conclusions. WE proposed the PK/PD model of DEX to understand better the BIS and CO changes observed after surgery. The measured CI values were in the reference range showing that the used doses of DEX ensured stable cardiac function in the studied patients.
AI FRAMEWORK AGAINST IDS IN DIGITAL FORENSICS
Authors:   ARULMIGU KAPALEESHWARAR ARTS AND SCIENCE COLLEGE KOLATHUR, CHENNAI - 99, MR Dr. V. J. Chakravarthy
Published: February 2023

In this work, we will propose an architecture for our machine learning experiments based on the evaluations this work made during the literature review. Ontology modelling and the pipeline technique will be discussed, along with an overview of their capabilities. In order to evaluate the algorithms, this work will continue to use our methods of gathering criminal and forensic data records.
Quality Assurance in Neutron Activation Analysis: Simulation and a Continuous Improvement Approach
Authors: Didi Abdessamad , Aarab Iliasse , Bounouira Hamid , Amsil Hamid , Badague Abdelouahab , Laraki Khalid , Marah Hamid , Dekhissi Hassane
Published: February 2023

To sustain and advance the development of our laboratory, it is imperative for the laboratory 1 personnel to consistently deliver high-quality products and services that meet customer expectations. 2 The progress of productivity and the pace of technological advancements result in constant evolution 3 of measurement procedures, analytical techniques, and overall work methods. Our research within 4 the Neutron Activation Analysis (NAA) laboratory is aimed at contributing to the establishment of 5 quality assurance that complies with the ISO 17025 standard. As such, the laboratory implements 6 quality-oriented approaches to foster a culture of continuous improvement in its detector operations 7 and enhance customer satisfaction.
The Genetics of Fitness Reorganization During the Transition to Multicellularity: The Volvocine regA-Like Family as a Model
Authors: Grochau-Wright Zachariah I. , Nedelcu Aurora M. , Michod Richard E.
Published: February 2023

The evolutionary transition from single-celled to multicellular individuality requires organismal fitness to shift from the cell-level to the cell group. This reorganization of fitness occurs by allocating the two components of fitness, survival and reproduction, between two specialized cell types in the multicellular group – soma and germ, respectively. How does the genetic basis for such fitness reorganization evolve? One possible mechanism is the co-option of life-history genes present in the unicellular ancestors of a multicellular lineage. Single-celled organisms must regulate their investment in survival and reproduction in response to environmental changes, particularly decreasing reproduction to ensure survival when stressed. Such stress response life-history genes can provide the foundation for the genetic basis for cellular differentiation in multicellular lineages. The regA gene family in volvocine green algae provides a model system to study how this co-option occurs. We discuss the origin and evolution of the volvocine regA gene family, including regA – the gene that controls somatic cell development in the model organism Volvox carteri. We hypothesize that the co-option of life history trade-off genes is a general mechanism involved in the transition to multicellular individuality, making volvocine algae and the regA family a useful template for similar investigations in other lineages.
Энтропийная регуляризация разрывного метода Галеркина для двумерных уравнений Эйлера в триангулированных областях
Authors: Криксин Юрий Анатольевич , Kriksin Yury Anatolievich , Тишкин Владимир Федорович , Tishkin Vladimir Fedorovich
Published: February 2023

Построена энтропийная регуляризация разрывного метода Галеркина в консервативных переменных для двумерных уравнений Эйлера в областях, разбитых на нерегулярные треугольные ячейки. На основе использования локальных ортогональных линейных базисных функций в треугольной ячейке предлагается новый ограничитель наклонов. В целях обеспечения выполнения дискретного аналога энтропийного неравенства в треугольной ячейке строится специальный ограничитель наклонов.
Численные эксперименты с моделью динамики океана NEMO и усвоением данных наблюдений с дрифтеров ARGO
Authors: Беляев Константин Павлович , Belyaev Konstantin Pavlovich , Кулешов Андрей Александрович , Kuleshov Andrey Aleksandrovich , Реснянский Юрий Дмитриевич , Resnyanskii Yurii Dmitrievich , Смирнов Илья Николаевич , Smirnov Il'ya Nikolaevich , Фадеев Р Ю , Fadeev R Yu
Published: February 2023

Исследуется пространственно-временная изменчивость характеристик модели циркуляции океана Nucleus for European Modelling of the Ocean (NEMO) с усвоением данных по методу обобщенного фильтра Калмана (Generalized Kalman filter (GKF)), ранее разработанному авторами. Проведены численные эксперименты с глобальной версией модели NEMO на сетке ORCA1 и с использованием нового способа определения ключевых параметров метода GKF. Проведено моделирование на выбранном временном интервале в один месяц пространственно-временной изменчивости характеристик океана по модели NEMO как с применением метода усвоения данных GKF с использованием архива данных наблюдений с дрифтеров Argo на различных горизонтах, так и без усвоения. Проанализированы результаты численных экспериментов.
Pengembangan Program Latihan Freeletics Terhadap Indeks Massa Tubuh (Imt) Dan Vo2max di Komunitas Freeletics Kota Surabaya
Authors: Renato Adrian , Cholid Abd , Suharti
Published: February 2023

Kegiatan belajar dan pekerjaan yang memiliki tuntutan tugas yang harus diselesaikan dengan batas waktu yang relatif singkat. Berdampak pada berkurangnya intensitas waktu beristirahat yang dapat menimbulkan berbagai macam penyakit, meningkatnya stres seseorang yang dapat memicu kelebihan berat badan. 13,5% orang dewasa usia 18 Tahun keatas mengalami kelebihan berat badan, 28,7% mengalami Obesitas (IMT ≥ 25). Kapasitas VO2Max juga berpengaruh terhadap kinerja yang baik seseorang dalam menunjang setiap produktifitasnya dan seseorang memiliki kapasitas VO2Max yang berbeda-beda. Freeletics adalah olahraga yang menggunakan berat badan sebagai hambatannya. Melatih kekuatan otot dan daya tahan tubuh. Sifat gerakan yang intens membuat tubuh mampu membakar banyak kalori dalam tubuh. Komunitas olahraga Freeletics Kota Surabaya merupakan salah satu komunitas olahraga yang dapat memicu seseorang lebih tertarik untuk melakukan aktifitas olahraga, dapat menambah pertemanan, berpotensi meningkatkan hubungan kerjasama dalam suatu pekerjaan, dan dapat menghindari efek bosan dalam melakukan olahraga sendirian. Peneliti merumuskan penelitian pengembangan program latihan Freeletics terhadap indeks massa tubuh (IMT) dan VO2Max di komunitas Freeletics kota Surabaya. Metode penelitian menggunakan Metode Kuantitatif, dengan rancangan dukungan eksperimen Pre-Experiment dengan One Group Pretest-Posttest difungsikan pada suatu kumpulan tertentu. Berdasarkan klasifikasi sesuai Sampling Purposive yang memenuhi  berjumlah 8 orang tergabung dalam 12 Weeks Program Batch 8. Beberapa uji analisis yang digunakan untuk mengolah data seperti uji normalitas, uji homogenitas, dan uji t. hasil dari pengolahan data uji normalitas, uji homogenitas, dan uji t sebagai berikut: (a) Uji Normalitas Pengolahan data: (1) Pretest dan Postest Indeks Massa Tubuh (IMT) dengan skor Signifikasi 0.181 > 0,05 dan 0.402 > 0,05, sehingga berdasarkan uji normalitas data IMT mengasilkan distribusi normal. (2) Pretest dan Postest VO2Max dengan skor Signifikasi Pretest dan Postest VO2Max pada uji Kolmogorov-Smirnov 0.332>0,05 dan 0.263>0,05, sehingga berdasarkan uji normalitas data VO2Max mengasilkan distribusi normal; (b) Uji Homogenitas di dapat skor Signifikasi IMT dan VO2Max pada uji homogenitas sebesar 0.003<0,05, hasil data data bervariasi atau bersifat Heterogen; (c) Uji t diperoleh skor Sig. (2-tailed) sebesar (0.004 < dari 0.05), menunjukan nilai Sig. (2-tailed) lebih kecil nilai probabilitas 0,05 dan dapat disimpulkan ada pengaruh program latihan Freeletics terhadap indeks massa tubuh (IMT) dan VO2 Max.
Hubungan Kapasitas Aerobik Maksimal (Vo2max) Dan Kapasitas Vital Paru Dengan Denyut Nadi Pemulihan Pada Atlet Putra Klub Bola Basket Universitas Negeri Jakarta
Authors: Fahmi Fadlilah
Published: February 2023

Abstrak. Penelitian ini bertujuan untuk memperoleh informasi hubungan antara Kapasitas Aerobik Maksimal (VO2Max) dan Kapasitas Vital Paru dengan Denyut Nadi Pemulihan. Penelitian ini dilakukan di lintasan lari (Track) Stadion Atletik Rawamangun Jl. Pemuda No. 6 Rawamangun – Jakarta Timur. Penelitian ini menggunakan metode survey dengan Teknik korelasional, sampel yang digunakan yaitu atlet Putra Klub Bola Basket Universitas Negeri Jakarta sebanyak 20 orang, dengan pengambilan sampel ini menggunakan Teknik purposive sampling. Teknik pengujian hipotesis dilakukan dengan menggunakan Teknik analisis statistika korelasi sederhana dan korelasi ganda yang dilanjutkan dengan uji-t pada taraf signifikansi a = 0.05. Hasil penelitian menunjukkan: I. Terdapat hubungan yang berarti antara Kapasistas Aerobik Maksimal (VO2Max) dengan Denyut Nadi Pemulihan, dengan persamaan garis regresi linier 1, koefisien korelasi (rX1Y) = 0.648 dan koefisien determinasi (rX1Y2) = 0.4199, yang berarti variable Kapasitas Aerobik Maksimal (VO2Max) memberikan sumbangan terhadap Denyut Nadi Pemulihan sebesar 41.99%. II. Terdapat hubungan yang berarti antara Kapasistas Vital Paru dengan Denyut Nadi Pemulihan, dengan persamaan garis regresi linier 2, koefisien korelasi (rX2Y) = 0.499 dan koefisien determinasi (rX2Y2) = 0.2490, yang berarti variable Kapasitas Vital Paru memberikan sumbangan terhadap Denyut Nadi Pemulihan sebesar 24.90%. III. Terdapat hubungan yang berarti antara Kapasistas Aerobik Maksimal (VO2Max) dan Kapasitas Vital Paru secara bersama-sama dengan Denyut Nadi Pemulihan, dengan persamaan garis regresi linier 1 2, koefisien korelasi ganda (rY1-2) = 0.656 dan koefisien determinasi (rY1-22) = 0.4303, yang berarti variable Kapasitas Aerobik Maksimal (VO2Max) dan Kapasitas Vital Paru secara Bersama-sama memberikan sumbangan terhadap Denyut Nadi Pemulihan sebesar 43.03%
Molecular detection by some virulence genes of Salmonella enterica subsp. enterica isolated from the stool of children with diarrhea
Authors: Maaroof Mohammed Nadhir , Dhayea Ahmed Hussein
Published: February 2023

Diarrhea is a real disease in childhood which could cause death. Therefore, this study was conducted to isolate Salmonella from 350 stool samples taken from children under five years in age, suffering from diarrhea during the period from March 2019 to March 2020 in Tikrit city / Iraq. The results showed the possibility to isolate ten isolates of Salmonella enterica subsp. Enterica, an infection rate, represents 2.875% of the total rate of patients who suffer from diarrhea. The virulence genes were investigated for ten isolates of S. enterica subsp. enterica, the result is that all isolates possessed the genes stn, invA, lpfA with an appearance percentage of 100%, while the percentage of appearance of pefA and fimH genes was 80% and 60%, respectively. All these isolates as Iraqi detection have been submitted to NCBI then accepted as   ten Iraqi strains were in NCBI. All strains were concordance of 99-100% with the Salmonella enterica subsp. enterica Strains of Taiwan (CP085821.1), the United Kingdom (OU943338.1), China (CP085699.1), South Korea (CP077760.1), Pakistan (OK035700.1) and Hong Kong (CP0823381.1) in addition to four US states.
Watermark Based on Singular Value Decomposition
Authors: Qazzaz Ali Abdulazeez Mohammed Baqer , Kadhim Neamah Enad
Published: February 2023

Watermarking operation can be defined as a process of embedding special wanted and reversible information in important secure files to protect the ownership or information of the wanted cover file based on the proposed singular value decomposition (SVD) watermark. The proposed method for digital watermark has very huge domain for constructing final number and this mean protecting watermark from conflict. The cover file is the important image need to be protected. A hidden watermark is a unique number extracted from the cover file by performing proposed related and successive operations, starting by dividing the original image into four various parts with unequal size. Each part of these four treated as a separate matrix and applying SVD on it, the diagonal matrix is selected to determine its norm. The four norms will be processed to produce one unique number used as a watermark and this number can be developed  in future by exploiting some other features in constructing watermark number other than SVD process to construct two watermark numbers, each one of them owned special methodology, for avoiding some challenges and changings in the transformation process.
Effects of Water Stress, Nitrogen, Magnesium and their Interactions on Some Growth Characteristics and Essential Oil content of Rosemary (Rosmarinus officinalis L.)
Authors: Khaleel Nahla M. A. , Sarmamy Abdulghany O. I.
Published: February 2023

A factorial experiment was applied with four replicates on rosemary plants (Rosmarinus officinalis L.) grown in pots inside the glasshouse of the Department of Biology, College of Science, Salahaddin University, Erbil, Iraq, during April, 2019 to July, 2020, to determine the effects of soil moisture content ( SM1: 100% and SM2: 60% field capacity), nitrogen fertilizer (N1: 100, N2: 200 and N3: 300kg/hectare), and magnesium fertilizer (Mg1: 0.0, Mg2: 30 and Mg3: 60kg/hectare) and their interactions on some growth characteristics  and essential oil content of rosemary plants. Two cuttings were taken from rosemary shoots (on March, 2020 and July, 2020) after 12 and 15 months of planting respectively. Results showed that cutting 1: SM2 decreased plant height, number of branches, Shoot fresh weight (FW), shoot dry weight (DW), leaves DW & stem DW. N3 increased plant height, number of branches, Shoot FW, shoot DW, leaves DW, stems FW & stem DW. Interaction treatment SM1N3Mg3 increased plant height, Shoot FW, shoot DW, leaves DW, stems FW and stem DW, while in cutting 2: SM2 decreased shoot DW, stems FW and stem DW. N3 increased Shoot FW and stem DW. Mg3 increased Root FW, but decreased stems FW. SM1N3Mg1 increased stem DW. In cutting 1+ cutting 2, SM2 decreased accumulative stem DW and biological yield FW. N3 increased accumulative Shoot FW; Accumulative leaves DW, accumulative stem FW, accumulative yield FW and biological yield DW. Mg3 increased biological yield FW, while SM1N3Mg3 treatment increased accumulative shoot DW, accumulative leaves DW, biological yield FW, and biological yield DW. In the second harvest, SM2 and Mg2 decreased rosemary essential oil %, N3 and SM1N3Mg2increased EO% and concrete content, while SM1Mg2 increased EO.
Numerical Investigation, Error Analysis and Application of Joint Quadrature Scheme in Physical Sciences
Authors: Jena Saumya Ranjan , Nayak Damayanti , Acharya Mitali Madhumita , Misra Satya Kumar
Published: February 2023

In this work, a joint quadrature for numerical solution of the double integral is presented. This method is based on combining two rules of the same precision level to form a higher level of precision. Numerical results of the present method with a lower level of precision are presented and compared with those performed by the existing high-precision Gauss-Legendre five-point rule in two variables, which has the same functional evaluation. The efficiency of the proposed method is justified with numerical examples. From an application point of view, the determination of the center of gravity is a special consideration for the present scheme. Convergence analysis is demonstrated to validate the current method.
Best Proximity Point Theorem for α ̃–ψ ̃-Contractive Type Mapping in Fuzzy Normed Space
Authors: Sabri Raghad I. , Ahmed Buthainah A. A.
Published: February 2023

The best proximity point is a generalization of a fixed point that is beneficial when the contraction map is not a self-map. On other hand, best approximation theorems offer an approximate solution to the fixed point equation . It is used to solve the problem in order to come up with a good approximation. This paper's main purpose is to introduce new types of proximal contraction for nonself mappings in fuzzy normed space and then proved the best proximity point theorem for these mappings. At first, the definition of fuzzy normed space is given. Then the notions of the best proximity point and - proximal admissible in the context of fuzzy normed space are presented. The notion of α ̃–ψ ̃- proximal contractive mapping is introduced. After that, the best proximity point theorem for such type of mapping in a fuzzy normed space is state and prove. In addition, the idea of α ̃–ϕ ̃-proximal contractive mapping is presented in a fuzzy normed space and under specific conditions, the best proximity point theorem for such type of mappings is proved. Furthermore, some examples are offered to show the results' usefulness.
Synthesis and Characterization of Grafted Chitosan Blending with Polyvinyl alcohol / Nanocomposite and Study Biological Activity
Authors: Saeed Ruwaidah S. , Attiya Hanaa G. , Obead Kawther Ayad
Published: February 2023

The study of biopolymers and their derivative materials had received a considerable degree of attention from researchers in the preparation of novel material. Biopolymers and their derivatives have a wide range of applications as a result of their bio-compatibility, bio-degradability and non-toxicity. In this paper, chitosan reacted with different aldehydes(2,4 –dichloro- benzaldehyde or 2-methyl benzaldehyde), different ketones (4-bromoacetophenone or 3-aminoacetophenone) to produce chitosan schiff base (1-4) . Chitosan schiff base (1-4) reacted with glutaric acid or adipic acid in acidic media in distilled water according to the steps of Fischer and Speier to produce compounds (5-12) respectively. Grafted chitosan (5-12) blended with synthetic polymer PVA to produce compounds (13-20), then these polymers were blended with nano Ag by using a hotplate stirrer for 60 min to produce nanocomposites. The synthesized polymers were identified via spectral analysis techniques, including FTIR , 1H-NMR and scanning electron microscope (SEM). Finally, studied anti-bacterial activities of some of the prepared polymers.
STRAS:a snakemake pipeline for genome wild Short Tandem Repeats Annotation and Score
Authors: Zhang Mengna
Published: February 2023

High-throughput whole genome sequencing (WGS) is clinically used in finding single nucleotide variants and small indels. Several bioinformatics tools are developed to call short tandem repeats (STRs) copy numbers from WGS data, such as ExpansionHunter denovo, GangSTR and HipSTR. However, expansion disorders are rare and it is hard to find candidate expansions in single patient sequencing data with ~ 800,000 STRs calls. In this paper I describe a snakemake pipeline for genome wild STRs Annotation and Score (STRAS) using a Random Forest (RF) model to predict pathogenicity. The predictor was validated by benchmark data from Clinvar. True positive rate was 100%. True negative rate was 98.3%. False positive rate was 0% and false negative rate was 1.7%. Sensitivity was 100% and specificity was 93.6%. The results showed STRAS could be a useful tool for clinical researchers to find STR loci of interest and filter out neutral STRs. STRAS is freely available at https://github.com/fancheyu5/STRAS
Detect Acute Porphyrias in Emergency Departments (DePorED) – A pilot study
Authors: Diehl-Wiesenecker Eva , Blaschke Sabine , Wohmann Nils , Kubisch Ilja , Stauch Thomas , Mainert Mona , Helm Franziska , von Wegerer Sabine , Pittrow David , Frank Jorge , Stölzel Ulrich , Somasundaram Rajan
Published: February 2023

Background Acute porphyrias (APs) are a group of rare metabolic diseases related to a disturbed heme biosynthesis. Symptoms may first occur as life threatening attacks, comprising abdominal pain and/or variable neuro-psychiatric symptoms, thus leading to presentation in emergency departments (ED) first. Due to the low prevalence, diagnosis of AP is often missed, even after readmission to the ED. Therefore, strategies are needed to consider APs in ED patients with unexplained abdominal pain, especially since early and adequate treatment will avoid an unfavorable clinical course. Aim of this prospective study was to investigate the prevalence of APs in ED patients and thus, addressing feasibility of screening for rare diseases, such as APs in the real life setting. Methods From September 2019 to March 2021, patients presenting to the ED of three German tertiary care hospitals with moderate to severe prolonged abdominal pain (Visual Analog Scale, VAS > 4 out of 10 points) not otherwise explained were screened and prospectively enrolled. In addition to standard of care (SOC) diagnostics a blood and urine sample for plasma fluorescence scan and biochemical porphyrin analysis were sent to a certified German porphyria laboratory. Results Overall, of 653 screened patients, 68 patients (36 females; mean age 36 years) were included for biochemical porphyrin analysis. No patient with AP was detected. The most frequent discharge diagnoses included “abdominal and digestive symptoms” (n = 22, 32%), “gastroesophageal diseases” (n = 18, 27%), “infectious bowel disease” (n = 6, 9%) and “biliopancreatic diseases” (n = 6, 9%). Although not primarily addressed, we observed an increase in knowledge of the ED staffs at all study sites regarding our screening algorithm and thus, awareness for APs. Conclusions To the best of our knowledge, we performed the first prospective screening project for APs in the ED. Although we detected no patient with AP in this study, we demonstrated the feasibility of a multicenter screening process for APs by building up a well-working infrastructure comprising laboratory testing as well as data management. This enables the set-up of a larger scale revised follow-up study with a central focus on structured education, thus, possibly acting as blueprint for other rare diseases.
Metabolomic profiling of Wilson disease, an inherited disorder of copper metabolism, and diseases with similar symptoms but normal copper metabolism
Authors: Qiu Yijie , Su Mingchuan , Xiao Xina , Zhou Dingzi , Xie Linshen
Published: February 2023

Wilson’s disease (WD) is an inherited disorder that leads to copper accumulation, but the detailed pathogenic mechanism is uncertain and diagnosis can be difficult without genetic testing because of similarities to other more common diseases.To investigate the metabolomic features of WD, and elucidate its difference with other normal copper metabolism disease.We performed targeted and untargeted metabolomic profiling using ultra-high performance liquid chromatography-tandemmassspectrometry (UPLC-MS/MS) and liquid chromatography-tandemmassspectrometry (LC-MS).We compared the metabolomic profiles of two subgroups of WD patients, hepatic WD(H-WD)and neurological WD (N-WD); of H-WD patients and liver cirrhosis patients (who have similar symptoms, but normal copper levels);and of N-WD patients and Parkinson’s disease patients (who have similar symptoms, but normal copper levels). Pairwise comparisons indicated distinctive metabolomic profiles for male and female WD patients, H-WD and N-WD patients, N-WD and Parkinson’s disease patients, and H-WD and liver cirrhosis patients. We then used logistic regression analysis, receiver operating characteristic (ROC) analysis, and model construction to identify candidate diagnostic biomarkers that distinguish H-WD from liver cirrhosis, and N-WD from Parkinson’s disease. Based on the spatial distribution of the data obtained by PLS-DA analysis, we found that there are different hydrophilic metabolites (aminoacyl-tRNA biosynthesis; alanine, aspartate, and glutamate metabolism; phenylalanine metabolism; arginine biosynthesis; and nicotinate and nicotinamide) and lipophilic metabolites (TG(16:0_16:1_22:6), TG(16:0_16:0_22:6) and TG(16:0_16:1_22:5)) between H-WD and N-WD. Furthermore, WD patients have metabolic characteristics that distinguish it from other analogous diseases (liver cirrhosis and Parkinson's disease). Through analysis, WD showed significant differences in the levels of metabolites in some critical metabolism pathways and in the levels of many lipids. ROC analysis indicated that 3 metabolites may be considered as candidate biomarkers for diagnosing WD.
Interactive mechanical product innovation design method based on FBS extended by behavior layer
Authors: BAI Zhonghang , SUN Yiwei , ZHANG Jinzhu , LI Chenhui , HAO Yufan , TAN Runhua
Published: February 2023

Function-behavior-structure (FBS) method models the functional structure and principle scheme in conceptual design by connecting three variables: product function, behavior, and structure. The traditional FBS method cannot deal effectively with the cooperation problem between man and machine in the function achievement process. This paper proposes an FBS-based interactive mechanical product design method by extending the behavior layer. First, define and transform operational behavior from the function to the behavior layer. Second, the genetic engineering method is used in expected operational behavior design. In this part, the operational behavior as genetic information is constructed to operational behavior genes model by Extenics theory. Based on a homology product sample library, screen the target gene through the GloVe model and similarity algorithm. The original operational behavior is then modified to an expected one by Extenics transformation. Finally, the product structure is obtained through an analogy transformation process. This way, the operational behavior problem in the interactive mechanical product can be solved by this FBS design process. The feasibility and effectiveness of the proposed process are verified in the development of an apple picking device.
Extracting functionally accurate context-specific models of Atlantic salmon metabolism
Authors: Vik Jon Olav , Molversmyr Håvard , Øyås Ove , Rotnes Filip
Published: February 2023

Constraint-based models (CBMs) are used to study metabolic network structure and function in organisms ranging from microbes to multicellular eukaryotes. Published CBMs are usually generic rather than context-specific, meaning that they do not capture differences in reaction activities, which, in turn, determine metabolic capabilities, between cell types, tissues, environments, or other conditions. Only a subset of a CBM's metabolic reactions and capabilities are likely to be active in any given context, and several methods have therefore been developed to extract context-specific models from generic CBMs through integration of omics data. We tested the ability of six model extraction methods (MEMs) to create functionally accurate context-specific models of Atlantic salmon using a generic CBM (SALARECON) and liver transcriptomics data from contexts differing in water salinity (life stage) and dietary lipids. Three MEMs (iMAT, INIT, and GIMME) outperformed the others in terms of functional accuracy, which we defined as the extracted models' ability to perform context-specific metabolic tasks inferred directly from the data, and one MEM (GIMME) was faster than the others. Context-specific versions of SALARECON consistently outperformed the generic version, showing that context-specific modeling better captures salmon metabolism.
Hematological Characteristics of Autochthonous Hypermicrofilaremic Dirofilariosis in Dogs in Kannur District of Kerala
Authors: Edana Georgen G. , P PREENA , Balan C. , Sarangom Sherin B. , Vijayakumar K.
Published: February 2023

This study aimed to determine whether autochthonous high-intensity D. repens microfilaremia leads to haematological changes in companion dogs. Dogs with hypermicrofilaremia presented to the District Veterinary Centre, Kannur were selected for the study. A total of one hundred animals were positive for hypermicrofilariaemia with D. repens based on peripheral blood smear examination and Knott’s test. Of these, three dogs were concurrently positive for sheathed microfilaria (MF) of Brugia spp. Interestingly, an adult live worm of D. repens approximately eight cm in length was detected on a subcutaneous mass on the hind limb of a hypermicrofilaremic animal in the study. We compared the hematological parameters of 100 autochthonous hypermicrofilaremic dogs and 15 uninfected dogs. The hematological findings in the study are nonregenerative mild to moderate anemia, moderate to severe thrombocytopenia, leucocytosis with granulocytosis, lymphocytosis and monocytosis in comparison to the uninfected group of dogs. The pathogenicity of naturally occurring hypermicrofilaremia is poorly studied, and knowledge of its epidemiology, host-parasite relationship and impact on various organs is warranted for better prevention and control, especially in hot-spot areas.
Fractional mathematical modeling for the transmission dynamics of SARS-CoV-2 infection
Authors: Thabet Hayman , Kendre Subhash
Published: February 2023

This paper presents a mathematical model based on nonlinear PDEs of fractional veritable-order derivatives which describe the host population surviving on the transmission and evolution of the describes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Five host population groups have been considered, the susceptible, exposed, infected, recovered, and deceased (SEIRD) populations. The proposed model is governed by PDEs with fractional variable-order derivatives. The proposed model is new and has not been introduced before in its current formulation, therefore, the proposed technique is not compared with other techniques or real scenarios for the same model. The advantage of the used fractional partial derivatives of variable order that it can model the rate of change of subpopulation for the debated model. As an efficient tool to obtain the solution of the proposed model, a modified analytical technique based on the Adomian decomposition method is introduced. However, the present study is in general and can be applied to a host population of any country that can help inform public health interventions.
Retrospective judgments of confidence in a complex span task
Authors: Lau Giovanny , Moulin Chris J.A. , Portrat Sophie
Published: February 2023

Although the study of metamemory monitoring originated in predictions for simple span tasks, the study of metacognition for working memory (WM) has been somewhat neglected in comparison with long-term memory. We aimed to fill this gap by exploring the ability to self-assess WM operations. Thirty-four participants performed 16 series of complex span tasks and rated their confidence in a verbal recall paradigm. We manipulated the cognitive load (CL) based on the TBRS model in order to analyze the role of attentional resources on both WM and metacognitive evaluations. As expected, we found that recall is affected by cognitive load and we found standard serial position effects. Interestingly, metacognitive evaluations followed the same pattern, and measures of metacognitive sensitivity suggest that participants are able to make item-by-item retrospective judgements reflective of their performance. We discuss how these results contribute to our understanding of metacognitive access to working memory operations.