bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching professional disciplines in English to students of non-speech specialties: problems and prospects
Authors: Мохова О.Л. , Синицына И.А. , Мерзликина Н.И. , Вовси-Тиллье Л.А.
Published: April 2023

Анализ научной литературы и изучение опыта иноязычной подготовки студентов свидетельствуют о том, что существует потребность в дальнейшей разработке теоретических и практических аспектов иноязычных неречевых специальностей, способствующих эффективному овладению иностранным языком как средством межкультурного, профессионального общения в различных сферах научной деятельности. Сегодня иноязычная подготовка в высших учебных заведениях осуществляется на всех образовательно-квалификационных уровнях, которые характеризуются спецификой целей, задач, содержания, методов и условий обучения. Важным в процессе иноязычной подготовки студентов является развитие креативных умений, которые помогают личности проявлять творческую индивидуальность, активность, продуцировать оригинальные идеи, применять творческий подход в решении задач. Основной целью преподавания иностранного языка для неречевых специальностей является достижение уровня практического владения языком, что позволяет использовать его в профессиональной деятельности, научной работе и обеспечивает коммуникативную самостоятельность ученого в сферах профессионального и академического общения в устной и письменной формах.

Nowadays, more and more attention is paid to the good proficiency of graduates of non-linguistic universities in a foreign language (primarily English) for professional communication. This is due to the fact that it is these graduates who are largely entrusted with the task of global integration of Russia - economic, scientific, industrial, educational, political, etc. – which cannot be realized if the people directly involved in its implementation are not sufficiently prepared for foreign-language professional communication in the international arena. in particular, they will not be proficient in English as the "planetary" language of international professional communication. One of such approaches, which is becoming increasingly widespread and popular, is the development of English–language courses for teaching various university disciplines not in the native language of students, but in English, which provides so-called integrated learning - parallel mastery of one or another discipline of the university cycle and a significant improvement in their mastery of English. To solve the problem of teaching professional disciplines in non-linguistic universities of Russia, various innovative approaches to teaching English for professional communication are being introduced, which we have disclosed in this article.
Modern technologies as a means of developing the educational and creative potential of students in the conditions of inclusion"
Authors: Митясова О.А. , Лужкова О.А.
Published: April 2023

В статье представлен практический опыт реализации современных инновационных технологий в образовательной деятельности в условиях инклюзивного обучения. Описана сущность технологии уровневой дифференции необходимой при реализации Федеральных государственных образовательных стандартов. Отмечена значительная роль комплексного психологического сопровождения обучающихся с ограниченными возможностями здоровья при реализации инновационных технологий обучения и воспитания школьников.

The article presents the practical experience of implementing modern innovative technologies in educational activities in inclusive learning. The essence of the technology of level differentiation necessary for the implementation of Federal state educational standards is described. The significant role of complex psychological support of students with disabilities in the implementation of innovative technologies for teaching and educating schoolchildren is noted.
Vibrational second-harmonic generation spectroscopy provides insight into the screening response of the liquid water interface
Authors: Ray Kamal , Limaye Aditya , Ng Ka Chon , Saha Ankur , Shin Sucheol , Biswas Biswajit , Gaigeot Marie-Pierre , Pezzotti Simone , Willard Adam , Allen Heather
Published: April 2023

We use second harmonic generation (SHG) spectroscopy, molecular dynamics simulation, and theoretical modeling to study the response of the neat liquid water-air interface to changes in the potential of an external electrode positioned near the liquid, but out of direct contact. We observe a parabolic dependence of second harmonic intensity on applied potential. Based on standard theory, we associate this dependence with the response of the diffuse layer water molecules to changes in interfacial potential profile. Taking the literature value for this response leads to the unexpected conclusion that the electric fields within the diffuse layer are opposite in sign from those originating from the electrodes. This conclusion implies that the traditional continuum-based models of interfacial screening lack the complexity necessary to properly describe the potential profile of the liquid water-vapor interface. Effects such as overscreening in the topmost interfacial layer and extended correlations in the interfacial hydrogen bonding network may play a role in governing the response of the water interface to external fields.
Pharmacology and Therapeutic Potential of Benzothiazole Analogues for Cocaine Use Disorder
Authors: Boateng Comfort A. , Nilson Ashley N. , Placide Rebekah , Pham Mimi L. , Jakobs Franziska M. , Boldizsar Noelia , McIntosh Scot , Stallings Leia S. , Korankyi Ivana V. , Kelshikar Shreya , Shah Nisha , Panasis Diandra , Muccilli Abigail , Ladik Maria , Maslonka Brianna , McBride Connor , Ximello Sanchez Moises , Akca Ebrar , Alkhatib Mohammad , Saez Julianna , Nguyen Catherine , Kurtyan Emily , DePierro Jacquelyn , Crowthers Raymond , Brunt Dylan , Bonifazi Alessandro , Newman Amy H. , Rais Rana , Slusher Barbara S. , Free R. Benjamin , Sibley David R. , Stewart Kent D. , Wu Chun , Hemby Scott E. , Keck Thomas M.
Published: April 2023

The dopamine D4 receptor (D4R), a G protein-coupled receptor, is predominantly expressed in brain regions that control cognition, attention, and decision making. Previous studies have indicated that D4R-targeted ligands could be promising therapeutic targets for the treatment of several neuropsychiatric conditions, including substance use disorders (SUDs). There are currently no FDA-approved medications that selectively target D4Rs. New ligands may facilitate better understanding of the role of D4R-mediated signaling in drug-taking and drug-seeking behaviors. The present study focuses on the synthesis and evaluation of a novel series of benzothiazole analogues designed to target D4R. We identified several compounds with high D4R binding affinity (Ki ≤ 6.87 nM) and >91-fold selectivity over other D2-like receptors (D2R, D3R) with diverse partial agonist and antagonist profiles. Based on receptor affinity and functional analyses, 5f was identified as a potent low-efficacy partial agonist of the D4R and selected for further investigation. 5f was metabolically stable in rat and human liver microsome assays and displayed excellent brain penetration in rats. Using a within-session multidosing procedure, 5f (5, 15 and 30 mg/kg, i.p.) dose-dependently decreased i.v. infusions of three-unit doses of cocaine under a fixed-ratio (FR) FR3 schedule of reinforcement. These results are consistent with previous results produced by D4R-selective antagonists in SUD models, however off-target antagonism of 5-HT2A or 5-HT2B receptors may also contribute to these effects. Results with compound 5f support further efforts to target D4R in the treatment of SUDs. Further development of the benzothiazole scaffold may engineer out any serotonergic activity.
Redox-Neutral Decarboxylative and Desulfonylative C(sp3) Trifluoromethylation: Method Development and Mechanistic Inquiry
Authors: Seong Chris , Roberts Courtney
Published: April 2023

Sodium triflinate (CF3SO2Na) is an inexpensive bench stable radical CF3 source that is often activated by external oxidants such as peroxides. However, despite the commercial accessibility of CF3SO2Na, the salt has never been applied to decarboxylative trifluoromethylation due to challenges in controlled cross-radical coupling. We report a redox-neutral approach to decarboxylative C(sp3) trifluoromethylation of carboxylic acid derivatives. Mechanistic inquiry is performed to address the limitations in scope.
Liquid-liquid phase separation and viscosity in biomass burning organic aerosol and climatic impacts
Authors: Gregson Florence K. A. , Gerrebos Nealan G. A. , Schervish Meredith , Nikkho Sepehr , Schnitzler Elijah G. , Schwartz Carley , Carlsten Christopher , Abbatt Jonathan P. D. , Kamal Saeid , Shiraiwa Manabu , Bertram Allan K.
Published: April 2023

Smoke particles generated by burning biomass consist mainly of organic aerosol, referred to as biomass-burning organic aerosol (BBOA). BBOA influences the climate by scattering and absorbing solar radiation or acting as nuclei for cloud formation. The viscosity and the phase behavior (i.e. the number and type of phases present in a particle) are properties of BBOA that are expected to impact several climate-relevant processes but remain highly uncertain. We studied the phase behavior of BBOA using fluorescence microscopy, and showed that BBOA particles comprise two organic phases (a hydrophobic and a hydrophilic phase) across a wide range of atmospheric relative humidity (RH). We determined the viscosity of the two phases using a photobleaching method, and showed that the two phases possess different RH-dependent viscosities. The viscosity of the hydrophobic phase is largely independent of the RH from 0 to 95%. For temperatures less than 230 K, the hydrophobic phase is glassy (viscosity > 1012 Pa s) at RHs below 95%, with possible implications for heterogeneous reaction kinetics and cloud formation in the atmosphere. Using a kinetic multi-layer model (KM-GAP), we investigated the effect of two phases on the atmospheric lifetime of brown carbon within BBOA, which is a climate-warming agent. We showed that the presence of two phases can increase the lifetime of brown carbon in the planetary boundary layer and polar regions compared to previous modelling studies. Hence, liquid-liquid phase separation can lead to an increase in the predicted warming effect of BBOA on climate.
Coupled reaction equilibria enable the light-driven formation of metal-functionalized molecular vanadium oxides
Authors: Repp Stefan , Remmers Moritz , Rein Alexandra Stefanie Jessica , Sorsche Dieter , Carrella Luca M. , Rentschler Eva , Streb Carsten
Published: April 2023

The introduction of metal sites into molecular metal oxides, so-called polyoxometalates, is a key approach to tune their structure and reactivity. To-date, the complex solution mechanisms which govern metal-functionalizatio of polyoxometalates is still poorly understood. Here, we reveal the existence of a coupled set of light-dependent and light-independent reaction equilibria control the mono- and di-metal-functionalization of a prototype molecular vanadium oxide cluster. Comprehensive mechanistic analyses show that coordination of a single Mg2+ ion to the native species (NMe2H2)2[V12O32Cl]3- results in formation of the mono-functionalized system (NMe2H2)[(MgCl)V12O32Cl]3-. This species is photoactive, and irradiation with visible light triggers a second, light-dependent reaction equilibrium which drives the formation of the di-metal-functionalized species [(MgCl)2V12O32Cl]3-. The use cations which compete with Mg2+ can effectively inhibit the formation of the metal functionalized clusters. The study therefore demonstrates how external and internal stimuli can be used to control supramolecular polyoxometalate assembly.
Insight into the effect of contact ion pairs on C-H bond activation for the synthesis of Ru(III)-NHC complexes: A combined experimental and computational study
Authors: Srivastava Navdeep , Shahid Nida , Singh Amrendra K.
Published: April 2023

The effect of contact ion pairs and comparison of the three halide ions on the C-H activation during the synthesis of Ru(III)-NHC complexes 1a and 1b have been investigated. DFT modeling of two pathways for the formation of Ru(III)-NHC complexes, viz. halide coordination pathway and ion-pair pathway, reveals the effect of ion pairing. The ion-pair path is preferred for azolium salts with Cl- and I-, whereas with Br-, the reaction follows the halide coordination route leading to the mixed halide complex. The higher activation barrier for the reaction with Cl- ions can be explained in terms of greater stabilization of the intermediates, compared to the transition states, due to halide coordination or hydrogen bonding with Cl- ions. Furthermore, the successful synthesis of 1b from the reaction of RuCl3·3H2O and the corresponding imidazolium salt precursor with Cl- in dioxane at 100 °C validates the conclusions of the DFT studies.
High Throughput FTIR Analysis of Macro and Microplastics with Plate Readers
Authors: Cowger Win , Roscher Lisa , Chamas Ali , Maurer Benjamin , Gehrke Lukas , Jebens Hannah , Gerdts Gunnar , Primpke Sebastian
Published: April 2023

FTIR spectral identification is today's gold standard analytical procedure for plastic pollution material characterization. High-throughput FTIR techniques have been advanced for small microplastics (10 um - 500 um) but less so for large microplastics (500 um - 5 mm) and macroplastics (> 5 mm). These larger plastics are typically analyzed using ATR, which is highly manual and can sometimes destroy particles of interest. Furthermore, spectral libraries are often inadequate due to the limited variety of reference materials and spectral collection modes. We advance a new high-throughput technique to remedy these problems. FTIR plate readers are high throughput devices for measuring large particles (> 500 um). We created a new reference database of over 6000 spectra for transmission, ATR, and reflection spectral collection modes with over 600 plastic, organic, and mineral reference materials relevant to plastic pollution research. We also streamline analysis in plate readers by creating a new particle holder for transmission measurements using off-the-shelf parts and fabricating a non-plastic 96-well plate for storing particles. We validated the new database using Open Specy and demonstrated that transmission and reflection spectra reference data are needed in spectral libraries.
N-Heterocyclic Carbenes - the Design Concept for Densely Packed and Thermally Ultra-Stable Aromatic Self-Assembled Monolayers
Authors: Wróbel Mateusz , Cegiełka Daria , Asyuda, Andika , Kozieł Krzysztof , Zharnikov Michael , Cyganik Piotr
Published: April 2023

Self-assembled monolayers (SAMs) of N-heterocyclic carbenes (NHCs) on metal substrates are currently one of the most promising systems in context of molecular-scale engineering of surfaces and interfaces, crucial for numerous applications. Interest in NHC SAMs is mainly driven by their assumingly higher thermal stability compared to thiolate SAMs most broadly used at the moment. Most of the NHC SAMs utilize imidazolium as an anchoring group for linking molecules to the metal substrate via carbene C atom. It is well established in the literature that standing up and stable NHC SAMs are built only when using bulky side groups attached to nitrogen heteroatoms in imidazolium moiety, which, however, leads to monolayers exhibiting much lower packing density compared to thiolate SAMs. Here, by combined X-ray photoelectron spectroscopy, near-edge X-ray absorption fine structure spectroscopy, and temperature-programmed secondary ion mass spectrometry analysis, we demonstrate that using NHCs with small methyl side groups in combination with simple solution-based preparation leads to the formation of aromatic monolayers exhibiting at least double surface density, upright molecular orientation, and ultra-high thermal stability compared to the NHC SAMs reported before. These parameters are crucial for most applications, including, in particular, molecular and organic electronics, where aromatic SAMs serve either as a passive element for electrode engineering or as an active part of organic field effect transistors and novel molecular electronics devices.
MiR-532-3pinhibited the methylation ofSOCS2to suppress the progression of PC by targetingDNMT3A
Authors: Wang Kaiqiong , Gong Dongwei , Qiao Xin , Zheng Jinfang
Published: April 2023

Pancreatic cancer (PC) is one of the deadliest malignancies, with poor diagnosis and prognosis.miR-532-3phas been reported to be a tumor suppressor in various cancers, whereas the mechanism ofmiR-532-3pin the progression of PC remains poorly understood. In this study, it was found thatmiR-532-3pandSOCS2were down-regulated, whereasDNMT3Awas up-regulated in PC. Knockdown ofDNMT3Aor overexpression ofmiR-532-3psuppressed PC cell proliferation, invasion, and migration, as well as tumor formation in nude mice. DNMT3A induced the methylation ofSOCS2promoter.SOCS2knockdown reversed the inhibiting effect ofDNMT3Asilencing on PC cell growth.miR-532-3pdirectly bound toDNMT3Aand negatively regulated its expression while up-regulatingSOCS2levels.DNMT3Aoverexpression reversed the inhibiting effect ofmiR-532-3poverexpression on PC cell growth. In conclusion, the overexpression ofmiR-532-3pcould suppress proliferation, invasion, and migration of PC cells, as well as tumor formation in nude mice through inhibiting the methylation ofSOCS2by targetingDNMT3A.
Rumo à Educação Matemática inclusiva: reflexões sobre nossa jornada
Authors: Fernandes Solange Hassan Ahmad Ali , Healy Lulu
Published: April 2023

A proposta deste artigo é discutir alguns desafios associados ao ensino de matemática e ao desenvolvimento de estratégias de boas práticas, pautadas nos direitos, aspirações e potencial de todos os aprendizes. O programa de pesquisa “Rumo à educação matemática inclusiva” tem três objetivos principais: investigar novas formas de expressar conceitos matemáticos que respeitem a diversidade dos aprendizes; contribuir para a formação de professores, instrumentalizando-os para trabalhar em classes inclusivas e compreender a relação entre experiências perceptivas e conhecimento. Neste texto, compartilha-se a trajetória dos estudos desenvolvidos pela pesquisadora, apresentando resultados de algumas pesquisas realizadas em escolas públicas e privadas que envolveram o desenvolvimento e a análise de cenários inclusivos para a aprendizagem matemática. Tais cenários são planejados para oferecer estímulos multissensoriais e oferecem representações de ideias matemáticas por meio de sons, cores, músicas, movimentos e texturas. Os resultados das pesquisas indicam que os processos de aprendizagem são moldados pelos artefatos e pelas representações matemáticas disponíveis nos cenários para a aprendizagem e, também, pela forma com que os aprendizes interagem com o mundo. Nem sempre as trajetórias de aprendizagem seguem as sequências prescritas no currículo escolar e, nem por isso, essas trajetórias são menos válidas.
Conditions for the “Easy” Entry of Novice Teachers into the Professional Activity
Authors:   North Kazakhstan University named after M. Kozybayev, Petropavlovsk, Kazakhstan, Chemodanova Galina
Published: April 2023

In recent of years, Kazakhstan has been taking systemic measures to improve the status of the teacher and the attractiveness of the teaching profession, and to create certain conditions for retaining young teachers in the profession. However, the taken actions do not tackle the problem of ‘youthification’ of Kazakhstani schools. The paper explores the conditions for “easy” entry of novice teachers into the profession. The potential of non-formal education is described and justified. The research aims to develop a model of “easy entry” into the teaching profession based on the analysis of difficulties that novice teachers encounter. The obtained data enabled the author to identify the difficulties faced by young teachers in their professional activity, as well as the reasons for these challenges and possible ways of dealing with the problems. Based on the research findings, the role and potential of non-formal education in the “easy” entry into the teaching professional were explained. The significance of the study lies in changing the options in relation to the forms for improving professional competencies, creating conditions for creative self-expression and self-realization as a factor of successful entry into the professional activity.
Speech Portrait of Children of the Indigenous People of the North in the Process of Teaching Mathematics
Authors:   Federal Institute of Native languages of the Peoples of the Russian Federation, Yakutsk Russia, Spiridonova Natalya
Published: April 2023

The article presents a scientific description of the collective speech portrait of primary school students in the process of teaching mathematics in rural educational institutions located in the places of the indigenous people of the North, Siberia and the Far East of the Russian Federation. The material for the scientific description of the speech portrait in the context of bilingualism was the results of studies conducted in 4 regions of Russia: the Republic of Sakha (Yakutia), the Republic of Buryatia, the Yamalo-Nenets Autonomous Okrug, the Khanty-Mansiysk Autonomous Okrug – Yugra. In total, the study covered 165 respondents (students, teachers and parents). During the study, the scientific literature and statistical data on the studied regions were analyzed. There were such research methods as observation, conversation, interviews, questionnaires, transcription of audio recordings, quantitative and qualitative analysis of oral and written works. The theoretical and methodological basis of the study was the work of scientists devoted to the problems of linguistic personality, speech portrait, the formation and development of mathematical speech. When creating a speech portrait, sociocultural, sociolinguistic, psychological-pedagogical, ethnolinguistic factors influencing the development of oral and written mathematical speech were taken into account. Audio recordings of oral speech and written test papers of students were also analyzed. The collective speech portrait was described on the basis of an integrated approach involving socio-psycholinguistic characteristics, descriptions of the levels of development of oral and written mathematical speech, as well as features of speech culture in formal and informal communication. The results of the study can provide methodological assistance in organizing educational activities for the development of mathematical speech.
Exposure to emotions and postural stability in deaf youth
Authors: Regin Kamila , Zaborowska-Sapeta Katarzyna , Kowalski Ireneusz
Published: April 2023

Introduction

The population of deaf people is a heterogeneous group. Understanding the significant variables that affect motor, socio-emotional and cognitive development sets the direction and quality for subsequent developmental stages and provides the opportunity to select appropriate compensatory methods for deaf individuals.

Aim

The aim of the study was to verify the visual effect of the emotions of joy and anger on one of the dimensions of eye-hand coordination, i.e. postural stability among deaf and hearing youth.

Material and methods

Study subjects: 120 teenagers aged 13–17 years. The test group comprised 60 subjects with profound bilateral sensorineural hearing loss, while the control group comprised 60 hearing junior high school students. The study used a computerised stabilometric platform and photographs sourced from an affective image database Montreal Set of Facial Displays of Emotion.

Results and discussion

In deaf youth, a switch in the stability of the body occurs, as compared to hearing youth. The results obtained indicate the need for the activation of cognitive, emotional and motor resources of deaf people with an area of multiple modalities taken into account.

Conclusions

Human development should be regarded as a continual process in relation to compensatory capacity.
Altered States: LGBTQ-R
Authors: Baker Daniel
Published: April 2023

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Foreword: Roma LGBTI, Feminist Movement and Scholarship
Authors: Mate Dezso
Published: April 2023

Foreword of the thematic issue Roma LGBTI, Feminist Movement and Scholarship
Staging the Romani Queer Revolution: New Approaches to the Study of Romani Queerness
Authors: Heljic Arman
Published: April 2023

I In this paper, I provide an intersectional analysis of Roma Armee, a theatre play staged at Berlin’s Maxim Gorki theatre. I wish to challenge preconceptions and representations of Romani queer and feminist identities by investigating the personal narratives and self-envisioning of queer and feminist Romani performers. While there are notions that Romani queers live only as victims, perpetrators of violence, or unwitting exoticized objects of desire for mainstream queer consumption, I favour a more complex image, showing how some Romani queers articulate their own sexuality, race, class, and agency. I look at how these articulations are met in some Romani communities, and by majoritarian audiences in Berlin and Stockholm, in order to problematize the complex nature of being a minority within a minority. I end with remarks on the revolutionary potential of the play, by arguing that the play creates spaces for healing and can be seen as a significant contribution to an epistemic and ontological shift when it comes to Romani queer and feminist knowledge production.
Natalia Molina, Ramon Gutiérrez, and Daniel HoSang, eds. 2019. Relational Formations of Race: Theory, Method, and Practice. Berkeley: University of California Press.
Authors: Wakeley-Smith Dalen C. B.
Published: April 2023

Book review
Romani Students’ Responses to Antigypsyist Schooling in a Segregated School in Romania
Authors: Dragos Simina
Published: April 2023

In this article I explore the responses of Romani students in a segregated school in Romania to majoritarian deficit narratives constructed about them, investigating the specific nature of such deficit discourses and the specific strategies of resistance deployed by the students. To do so, I designed a theoretical framework which fused elements of Foucauldian and Critical Race Theory (CRT). The case study was underpinned by principles of in-depth critical qualitative research, explicitly addressing the racial, political and systemic nature of educational inequalities in Romania. I spent two weeks in a segregated secondary school, in which Romani students were tracked into Romani-only class groups. I observed 12 lessons and interviewed three white Romanian teachers and 11 Romani students. The findings suggested that teachers mobilized deficit discourses about Romani families, culture, cognitive abilities, and potential, reflected in their pedagogical strategies and justifications of Romani students’ ‘school failure’. Students resisted such assumptions through counterstorytelling, naming oppression, class disruption, and refusal of the ‘rules of schooling’, such as homework. I argue that this resistance highlights Romani students’ critical thinking and agency. Among others, the findings indicate the need for urgent change in Romanian teacher training and educational policy.
Earnings Management in the Charitable Sector: A Canadian Study
Authors: Cyr Dominic , Landry Suzanne , Fortin Anne
Published: April 2023

This article examines whether charitable organizations use discretionary accruals to manage their surplus or deficit. Linear regression was used to analyze the financial data of a broad sample of Canadian charitable organizations. Results showed that discretionary accruals were used to manage these income figures. This approach is compounded by the magnitude of grants, public benefit, and leverage. The results hold whether the charity anticipates a surplus or a deficit, but not if it displays a high level of public benefit. In that case, charities with an anticipated surplus increase their use of discretionary accruals to decrease earnings, whereas charities that anticipate a deficit are not inclined to manage their deficit toward zero. This study complements prior literature on nonprofits and shows that even though tax laws differ among countries, charity managers in various contexts are motivated to manage earnings and are influenced by various factors in doing so.
Do Service-Providing Nonprofits Contribute to Democratic Inclusion? Analyzing Democracy Promotion by Canadian Homeless Shelters
Authors: Kopec Anna , Pue Kristin
Published: April 2023

Nonprofits are key social service providers in many Western welfare states. Yet the nonprofits that deliver government-funded public services are also an important part of civil society and, in theory, promote democratic inclusion through their democratic civil society function. But to what extent do welfare-providing nonprofits carry out democracy-promoting activities in reality and what do these activities include? Using a survey distributed to Canadian charities that operate government-funded homeless shelters, we find evidence of activities falling within three areas of democracy promotion: support for political participation, internal democratic governance, and representative voice. The variation amongst different activities is presented in ideal types, which can inform future studies of the democratic function of nonprofits. Our empirical results point to a vital role of homeless shelters that extends beyond the provision of basic needs and contribute to a better understanding of the modalities of democratic inclusion for excluded populations.
Results of a multicentre observational program to study the efficacy and safety of multidose menotropin in patients with male infertility.
Authors:   N. Lopatkin Research Institute of urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation, Apolikhin O.I. ,   Moscow, Russia, Bogolyubov S.V. ,   National Research Center for Endocrinology of Ministry of Health of Russian Federation; Moscow, Russia, Efremov E.A. ,   Department of Urology, Andrology and Oncourology of Pirogov Russian National Research Medical University; Moscow, Russia, Mskhalaya G.Zh. ,   department of preventive medicine, European Medical Cente, Krasnyak S.S. ,   N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – Branch of the National Medical Research Centre of Radiology of the Ministry of Health of Russian Federation; Moscow, Russia
Published: April 2023

Introduction. Currently, menotropins are widely used to treat male infertility, both to stimulate spermatogenesis and to compensate for hormonal imbalance. But the actual practice of using menotropins may differ from the recommendations given by the manufacturer. Therefore, observational programs are particularly important, which allow assessing the effectiveness of a drug in routine practice. Purpose. To establish prognostic criteria for response to short and stadard course of multidose menotropin therapy in men with pathospermia. Materials and methods. The study was designed as a multicentre, prospective, observational cohort study. The study included 1120 men with infertility enrolled between January 2020 and April 2021. The study included men with the absence of pregnancy during 12 months of regular unprotected sexual activity. The average duration of infertility was 20.6 months. As a treatment, men received multidose menotropin at a dosage of 75 IU, 112.5 IU or 150 IU every other day with hCG 2000 IU 2-3 times a week. Sperm parameters and hormones (total testosterone, Sex hormone-binding globulin - SHBG, luteinizing hormone - LH, follicle stimulating 12 months - FSH, Inhibin B, estradiol) were evaluated before treatment and for 12 months. Results. When comparing the parameters of the spermogram, it was noted that without differentiation according to the prescribed dose, after 3 months of administration, the concentration of spermatozoa increased by 32.6%, the total number of spermatozoa in the ejaculate increased by 32.3%, progressive mobility increased by 20.7%, the proportion of morphologically normal forms increased increased by 34.8%. The level of total testosterone after 3 months of use of multidose menotropin increased by 33.6%. The levels of inhibin B and estradiol did not change significantly. When using multi-dose menotropin for 12 months, sperm concentration increased by 88.5%, the total number of spermatozoa in the ejaculate increased by 55.3%, progressive mobility increased by 42%, the proportion of morphologically normal forms increased by 64.3%. Conclusions. We found the increase of the effectiveness of menotropins with an increase in the duration of their use and an increase in dosage.
Urinary disorders and quality of life in patients with BPH after transurethral resection of the prostate.
Authors:   department of hospital surgery, oncology and urology, Medical Institute of Petrozavodsk State University1, urologist of the Department of Urology, V.A. Baranov Republican Hospital, Simanov R.N. ,   Russia, Amdiy R.E. ,   Department of Urology of I.P. Pavlov First St. Petersburg State Medical University; Russia, Al-Shukri S.Kh. ,   Department of Urology of I.P. Pavlov First St. Petersburg State Medical University; Russia, Alekseeva T.A. ,   Mathematics Department of St. Petersburg Branch of Institution of Higher Education National Research University Higher School of Economics; Russia
Published: April 2023

Introduction. Transurethral resection (TUR) of the prostate remains the gold standard for surgical treatment of patients with benign prostatic hyperplasia (BPH). A proportion of patients who have undergone a prostatic TUR for BPH continue to have urinary dysfunction. Aim. The aim of the study was to determine the incidence of urinary disorders and quality of life in the long-term postoperative period in patients after prostatic TUR. Materials and methods. We interviewed and surveyed 176 patients who underwent prostate TUR between 2018 and 2021. To determine the prevalence of lower urinary tract symptoms (LUTs) after prostate TUR, we surveyed 176 patients between 12 and 36 months after surgical treatment. The age of the patients surveyed ranged from 47 to 89 years. Results. 53.4% of the patients were completely satisfied with the surgical treatment and 46.6% reported various urinary disorders. According to the questionnaire about the IPSS scale 47.7% patients moderate to severe symptoms persisted after prostate TUR. In 21.6% of the patients quality of life due to urinary disorders was unsatisfactory, poor and very poor. However, moderate and severe symptoms as well as worsening quality of life were more often observed in the older age groups. Conclusions. After prostate TUR, 10.2% of patients have severe and 37.5% have moderate urinary dysfunction in the long-term postoperative period. These urinary disorders worsen quality of life and are more frequent in older patients.
Caracterización bibliométrica de Revista Alergia México
Authors: Bedolla-Barajas Martín , Morales-Romero Jaime
Published: April 2023

Objective: To characterize the scientific production of the Revista Alergia México from a bibliometric perspective.
Methods: Descriptive study, carried out from the bibliometric information of the Revista Alergia México, hosted in the PubMed (MEDLINE) and Scopus repositories.
Results: According to Pubmed, the total number of articles published between 1991 and 2021 was 1115 (annual mean; 37.2 ± 12.3); For its part, Scopus earned 1,541 articles during 1972 and 2021 (annual mean: 30.8 ± 14.9). In both repositories, original articles (49 and 78%, respectively) and review articles (21 and 12%, respectively) were the most frequently published documents. The most prominent themes include: asthma (32%), allergic rhinitis (16%) and drug allergy (9%). Public institutions in Mexico were the ones that published the largest number of articles. The country with the highest number of published documents was Mexico (54%), followed by Colombia (5%) and Spain (4%). According to Scopus, the 2020 citation index was 0.9; H-index of 15 and an impact factor of 0.150. During the 2016-2020 period, the annual rejection rate was 7 to 30%.
Conclusions: The main needs of Revista Alergia México consist of promoting its internationalization, publishing articles in English and achieving a higher impact factor in the coming years.
Keywords: Bibliometrics; scientific production; citation index; index-H; impact factor.
Variación geográfica en la prevalencia de asma en niños mexicanos durante la pandemia de la COVID-19
Authors: Bedolla Pulido Tonatiuh Ramses , Morales Romero Jaime , Bedolla Pulido Angie , Meza López Carlos , Valdez-Soto Jorge Alejandro , Bedolla-Barajas Martín
Published: April 2023

Objetivo: Estimar la prevalencia de asma en pacientes pediátricos, según su lugar de residencia en la República Mexicana, durante la pandemia por SARS-CoV-2.
Métodos: Estudio transversal, llevado a cabo a partir de la revisión de datos del Sistema de Vigilancia Epidemiológica para Enfermedades Respiratorias en México, analizados del 27 febrero al 5 de noviembre de 2020. Criterios de inclusión: pacientes que acudieron a la detección de infección por SARS-CoV2, menores de 18 años. La fuerza de asociación se estimó con la razón de momios.
Resultados: De 1,048,576 pacientes que acudieron a la detección de infección de SARS-CoV2, 35,899 correspondieron a pacientes pediátricos que cumplieron con los criterios del estudio. La prevalencia nacional de asma estimada fue de 3.9% (IC95%: 3.7-4.1%); la prevalencia mínima se observó en la región Suroeste (2.8%) y la máxima en el Sureste (6.8%); comparada con la región Suroeste, que registró la prevalencia mínima a nivel nacional, y la Noroeste (RM = 2.41) y Sureste (RM = 1.33) mostraron el mayor riesgo de asma en la población pediátrica.
Conclusión: La prevalencia de asma en niños mexicanos difirió notoriamente en los diferentes estados de la República Mexicana; sobresalieron las regiones Noroeste y Sureste. Este estudio pone de manifiesto el papel del medio ambiente en la prevalencia del asma en pacientes pediátricos mexicanos.
Infección por bacilo de Calmette-Guérin y enfermedad granulomatosa crónica por nuevas variantes patogénicas del gen NCF2 en la etnia maya. Reporte de dos casos
Authors: Peñafiel Vicuña Ana Karen , Coyata Guzmán Rogelio , González Reynoso Anelena , Palma Chan: Adolfo Gonzalo , Baeza Bastarrachea Ricardo , García Ruelas Sherel Amelia , Costta-Michuy1 Ángeles , Razo Requena Cielo , Leon Lara Ximena , Espinosa Padilla Sara , Espinosa-Rosales Francisco , Bustamante Jacinta , Blancas Galicia Lizbeth
Published: April 2023

Introducción: La enfermedad granulomatosa crónica (EGC) es un error innato de la inmunidad, se caracteriza por una susceptibilidad a padecer infecciones bacterianas y fúngicas y a una falta de regulación inflamatoria sistémica. Las variantes patogénicas en el gen CYBB se trasmiten con un patrón de herencia ligada al X; mientras que las variantes patogénicas presentes en los genes EROS, NCF1, NCF2, NCF4 o CYBA se trasmiten con un patrón de herencia autosómico recesivo.
Objetivos. Describir las características clínicas, inmunológicas y genéticas de dos pacientes con EGC e infección por BCG.
Métodos: En neutrófilos de sangre periférica se midió la producción de H2O2 y la expresión de las subunidades de la NADPH oxidasa. La detección de las variantes patogénicas fue por secuenciación Sanger del gen NCF2. La información clínica fue extraída de los expedientes por los médicos tratantes.
Resultados: Presentamos a dos lactantes masculinos de dos familias no relacionadas de la etnia maya, con EGC e infección por la vacuna de BCG. Se identificaron tres diferentes variantes patogénicas en el gen NCF2; por un lado, c.304 C>T (p.Arg102*) ya reportada, por otro lado, c.1369 A>T (p.Lys457*) y c.979 G>T (p.Gly327*) no reportadas.
Conclusiones: En pacientes con infección micobacteriana por BCG debemos sospechar en un error innato de la inmunidad, como la EGC. El diagnóstico de EGC se realiza a través de la detección de una falta de producción de radicales libres en los neutrófilos. Los pacientes reportados tuvieron variantes patogénicas en el gen NCF2, dos de ellas no han sido reportadas previamente en la literatura.
Alergia a medicamentos: aspectos fundamentales en el diagnóstico y tratamiento
Authors: Villarreal-González Rosalaura Virginia , Canel-Paredes Alejandra , Arias-Cruz Alfredo , Fraga-Olvera Alira , Delgado-Bañuelos Angélica , Rico-Solís Germán Agustín , Ochoa-García Itzel Vianey , Jiménez-Sandoval Jaime Omar , Ramírez- Heredia Jennifer , Flores-González José Valentín , Cortés-Grimaldo Rosa María , Zecua-Nájera Yahvéh , Ortega-Cisneros Margarita
Published: April 2023

Antecedentes: Cualquier sustancia prescrita en el tratamiento de algún padecimiento es capaz de producir eventos dañinos o desagradables, y se denominan reacciones adversas a medicamentos. Estas reacciones se originan por mecanismos inmunológicos y no inmunológicos.
Objetivos: Describir los mecanismos inmunológicos de las reacciones de hipersensibilidad a medicamentos, epidemiologia, factores de riesgo, clasificación, manifestaciones clínicas, diagnóstico, tratamiento y pronóstico.
Métodos: Se revisó la bibliografía actualizada, en inglés y español, asociada con reacciones de hipersensibilidad a medicamentos en las principales bases de datos. 
Resultados: Se describen los términos para definir las reacciones adversas y de hipersensibilidad a medicamentos, su clasificación y manifestaciones clínicas, métodos diagnósticos actuales y en estudio, algoritmos de tratamiento y pronóstico de los medicamentos más frecuentemente prescritos y con mayor prevalencia de eventos adversos reportados.
Conclusión: Las reacciones adversas a medicamentos representan un reto, con una fisiopatología compleja y no del todo comprendida. Su abordaje requiere un enfoque cuidadoso, porque no todos los fármacos cuentan con pruebas validadas para establecer el diagnóstico y tratamiento específico. Antes de indicar cualquier medicamento debe considerarse la gravedad de la enfermedad, disponibilidad de otros tratamientos y riesgos potenciales de sufrir eventos adversos.
HEREDITARY BREAST CANCER IN THE PUBLIC HEALTH SYSTEM OF FEDERAL DISTRICT (DF) – BRAZIL
Authors: Correa Tatiana Strava , Oliveira Eduarda Sabá Cordeiro de , Leite Ana Carolina Rathsam , Weis Luiza Nardin , Moura Fernanda Cesar , Leite Jéssica da Costa , Sandoval Renata Lazari , Sousa Romualdo Barroso de
Published: April 2023

Objective: The lack of financial resources challenges the inclusion of genetic testing in the Brazilian Public Health System. This study aims to describe the detection rate of germline pathogenic variants (GPVs) in patients at risk of hereditary breast cancer (BC) in the public hospitals of Brasilia, DF, as well as the clinical and demographic profile of patients (pts). Methods: Hereditary cancer risk assessment based on the National Comprehensive Cancer Network Criteria, version 1.2020 was performed on patients with a personal history of BC who were being followed in a public hospital (DF) between January 2021 and January 2022. Results: Among 217 female pts eligible for this study, 78 pts performed germline multigene panel testing out of pocket. Panels included 26–84 cancer susceptibility genes. Patients in this cohort were mainly from the center-west (46%) and northeast (31%) of Brazil. The median age of BC diagnosis was 42 years. Invasive ductal carcinoma represented 88% of the tumors. From a total of 78 BC, 52% were hormone receptor-positive, 23% HER2 positive, and 24% triple-negative. Most patients presented with locally advanced disease: 50% (n=39) IIB-IIIC and 8% (n=6) had metastatic disease. The detection rate of GPVs was 20% (n=16). Among these 16 patients, the most frequently mutated genes were BRCA1/2 (n=11, 68.5%) and TP53 (n=2, 12.5%). Conclusion: The overall detection rate of GPVs was similar to other worldwide studies. In comparison with other Brazilian studies, GPVs in TP53 were at lower rates, possibly because this cohort was enriched by patients from Brazilian center-west and northeast. Higher rates of advanced disease at BC diagnosis may impact treatment outcomes. The lack of access to genetic testing in the public health system takes away the opportunity for cancer prevention, more effective treatments, and proper family risk assessment.
DOES THE BODY MASS INDEX (BMI) IMPACT THE OVERALL SURVIVAL (OS) OF BRAZILIAN WOMEN WITH BREAST CANCER (BC) WHO HAVE ACHIEVED PATHOLOGICAL COMPLETE RESPONSE (PCR) AFTER NEOADJUVANT CHEMOTHERAPY (NCT)?
Authors: Richter Fernanda Grace Bauk , Mattar André , Antonini Marcelo , Real Juliana Monte , Lopes Reginaldo Guedes Coelho , Gebrim Luís Henrique
Published: April 2023

Objective: This study aimed to evaluate the impact of obesity on the survival of patients with breast cancer (BC) treated with neoadjuvant chemotherapy (NCT) in two public hospitals in Brazil. Methods: This is a retrospective, multicenter study that evaluates women with BC at Pérola Byington (HPB) and State Public Servant (HSPE) hospitals between January 2011 and May 2020. Stages I–III, age ≥18 years, and who underwent NCT were included. Patients were categorized by the World Health Organization definition as follows: body mass index (BMI) < 18.5 kg/m2 : malnutrition; 18.5 to < 25 kg/m2 : normal; 25 to < 30 kg/m2 : overweight; ≥30 kg/m2 : obesity. Pathological complete response (pCR) was defined as the absence of invasive breast and axillary tumors. T-test or chi-square test was used to individually analyze the association of each variable between groups with and without pCR. Univariate and multivariate analyses were performed to calculate odds ratios, 95% confidence intervals of the independent variables BMI, age, and clinical stage, correlated with pCR with p-value <0.05 as statistically significant. Results: We enrolled 1779 patients, mean age of 50 years, and mean BMI of 28.08 kg/m2 . Most of them were in stage III (68%) with ductal histological type (95.11%). After NCT, 1435 patients had residual disease and 344 patients had pCR. The BMI ratio was 1.57% malnutrition, 30.58% normal, 35.13% overweight, and 32.72% obese. When the pCR was associated with BMI, there was no significance on overall survival (OS) when evaluating separate centers (HPB: p=0.46, HSPE: p=0.49) or together (p=0.83). Disease-free survival was only possible in HPB without significance (p=0.83) for BMI. Conclusion: This Brazilian study showed no interference of BMI on OS in patients submitted to NCT with pCR. There were few patients achieving pCR (19.34%) probably because of the initial stage. Despite not having an impact on survival, most of our women were overweight or obese (72.85%), showing how obesity is common in Brazilian women and should be understood as a public health problem.