bluuebunny/crossref_metadata_2025 huggingface dataset:
On modeling and real-time simulation of a robust adaptive controller applied to a multicellular power converter
Authors: Hamdi R. , Hadri Hamida A. , Bennis O.
Published: November 2022

Introduction. This paper describes the simulation and the robustness assessment of a DC-DC power converter designed to interface a dual-battery conversion system. The adopted converter is a Buck unidirectional and non-isolated converter, composed of three cells interconnected in parallel and operating in continuous conduction mode. Purpose. In order to address the growing challenges of high switching frequencies, a more stable, efficient, and fixed-frequency-operating power system is desired. Originality. Conventional sliding mode controller suffers from high-frequency oscillation caused by practical limitations of system components and switching frequency variation. So, we have explored a soft-switching technology to deal with interface problems and switching losses, and we developed a procedure to choose the high-pass filter parameters in a sliding mode-controlled multicell converter. Methods. We suggest that the sliding mode is controlled by hysteresis bands as the excesses of the band. This delay in state exchanges gives a signal to control the switching frequency of the converter, which, in turn, produces a controlled trajectory. We are seeking an adaptive current control solution to address this issue and adapt a variable-bandwidth of the hysteresis modulation to mitigate nonlinearity in conventional sliding mode control, which struggles to set the switching frequency. Chatter problems are therefore avoided. A boundary layer-based control scheme allows multicell converters to operate with a fixed-switching-frequency. Practical value. Simulation studies in the MATLAB / Simulink environment are performed to analyze system performance and assess its robustness and stability. Thus, our converter is more efficient and able to cope with parametric variation.
Interactive artificial ecosystem algorithm for solving power management optimizations
Authors: Mahdad B. , Srairi K.
Published: November 2022

Introduction. Power planning and management of practical power systems considering the integration and coordination of various FACTS devices is a vital research area. Recently, several metaheuristic methods have been developed and applied to solve various optimization problems. Among these methods, an artificial ecosystem based optimization has been successfully proposed and applied to solve various industrial and planning problems. The novelty of the work consists in creating an interactive process search between diversification and intensification within the standard artificial ecosystem based optimization. The concept of the introduced variant is based on creating dynamic interaction between production operator and consumer operator during search process. Purpose. This paper introduces an interactive artificial ecosystem based optimization to solve with accuracy the multi objective power management optimization problems. Methods. The solution of the problem was carried out using MATLAB program and the developed package is based on combining the proposed metaheuristic method and the power flow tool based Newton-Raphson algorithm. Results. Obtained results confirmed that the proposed optimizer tool may be suitable to solve individually and simultaneously various objective functions such as the total fuel cost, the power losses and the voltage deviation. Practical value. The efficiency of the proposed variant in terms of solution quality and convergence behavior has been validated on two practical electric test systems: the IEEE-30-bus, and the IEEE-57-bus. A statistical comparative study with critical review is elaborated and intensively compared to various recent metaheuristic techniques confirm the competitive aspect and particularity of the proposed optimizer tool in solving with accuracy the power management considering various objective functions.
Pengaruh Eksposur Media, Kinerja Proper dan Karakteristik Perusahaan terhadap Pengungkapan Emisi Karbon
Authors: Widia Aryni  , I Gusti Ketut Agung Ulupui  , Achmad Fauzi
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh eksposur media, kinerja PROPER dan karakteristik perusahaan terdiri dari umur perusahaan, pertumbuhan, dan leverage serta profitabilitas yang menjadi variabel kendali terhadap pengungkapan emisi karbon. Penelitian menggunakan data sekunder bersumber dari laporan tahunan, laporan keberlanjutan, laporan peringkat PROPER, dan situs perusahaan terkait dari perusahaan non keuangan yang terdaftar di Bursa Efek Indonesia (BEI) serta berpartisipasi pada program PROPER selama tahun 2016-2018. Sebanyak 129 sampel observasi terpilih melalui teknik purposive sampling yang diolah dengan analisis regresi data panel menggunakan Eviews 10. Berdasarkan hasil penelitian diketahui bahwa umur perusahaan berpengaruh positif dan eksposur media, pertumbuhan serta leverage berpengaruh negatif terhadap pengungkapan emisi karbon. Sedangkan, kinerja PROPER tidak memiliki pengaruh terhadap pengungkapan emisi karbon.
Analisis Faktor-Faktor Wajib Pajak Terhadap Realisasi Penerimaan PBB di Kabupaten Pekalongan
Authors: Indah Wulandari Wilujeng  , Imahda Khoiri Furqon
Published: November 2022

Penelitian ini bertujuan untuk mengetahui dan memeriksa atau menguji faktor faktor dalam diri wajib pajak terhadap keberhasilan realisasi penerimaan pajak bumi dan bangunan di Kabupaten Pekalongan. Dalam penelitian ini faktor faktor dalam diri wajib pajak meliputi, kesadaran perpajakan wajib pajak, pemahaman wajib pajak atas UU dan peraturan perpajakan PBB, persepsi wajib pajak tentang pelaksanaan sanksi denda PBB, pendapatan wajib pajak dan pelayanan fiskus berpengaruh terhadap keberhasilan realisasi penerimaan pajak bumi dan bangunan di Kabupaten Pekalongan. Populasi penelitian ini adalah wajib pajak PBB di Kabupaten Pekalongan yang terdaftar dalam Daftar Himpunan Ketetapan Pajak (DHKP) tahun 2010. Data yang diperoleh berupa data sekunder. Kesadaran wajib pajak berpengaruhsecara signifikan terhadap kepatuhan wajib pajak, pengetahuan perpajakan berpengaruh secara signifikan terhadap kepatuhan wajib pajak. Pengetahuan perpajakan dan tingkat pendidikan secara signifikan juga mempengaruhi kepatuhan wajib pajak.
Faktor Yang Mempengaruhi Keterandalan dan Ketepatwaktuan Pelaporan Keuangan Pada SKPD Jakarta Timur
Authors: Ilham Rizqullah Basri  , Indah Muliasari  , Etty Gurendrawati
Published: November 2022

Penelitian ini dilakukan untuk memberikan bukti empiris mengenai faktor yang mempengaruhi keterandalan dan ketepatwaktuan pelaporan keuangan pada SKPD Jakarta Timur. Teknik pengambilan sampel dalam penelitian ini menggunakan convenience sampling dengan tingkat kesalahan 5% dan menggunakan IBM SPSS v.25. Berdasarkan hasil analisis, Sumber Daya Manusia, dan Komitmen Organisasi berpengaruh positif dan signifikan terhadap keterandalan pelaporan keuangan. Pemanfaatan Teknologi Informasi tidak memiliki pengaruh positif dan tidak signifikan terhadap keterandalan dan Sistem Pengendalian Intern tidak memiliki pengaruh negatif dan tidak signifikan terhadap keterandalan pelaporan keuangan. Sumber Daya Manusia, Komitmen Organisasi dan Sistem Pengendalian Intern berpengaruh positif dan signifikan terhadap ketepatwaktuan pelaporan keuangan. Sementara Pemanfaatan Teknologi Informasi tidak memiliki pengaruh negatif dan tidak signifikan terhadap ketepatwaktuan pelaporan keuangan.
Analisis Komparatif Kinerja Keuangan Sebelum dan Saat Covid-19 pada Perusahaan yang Terdaftar di BEI
Authors: Ilal Hilaliyah  , Etty Gurendrawati  , Dwi Handarini
Published: November 2022

Pandemi Covid-19 selain berakibat ke kesehatan masyarakat berdampak pula ke perokonomian masyarakat akibat adanya kebijakan-kebijakan selama pandemi covid-19 seperti kebijakan Pembatasan Sosial Berskala Besar (PSBB), Work from Home (WFH) sehingga mobilitas masyarakat menjadi terhambat dan mengakibatkan operasi perusahaan tidak berjalan seperti biasanya. Penelitian ini bertujuan untuk menganalisis perbedaan kinerja keuangan sebelum dan saat pandemi virus covid-19 pada laporan keuangan perusahaan yang terdaftar di Bursa Efek Indonesia. Penelitian ini menggunakan metode event study. Penelitian ini termasuk penelitian kuantitatif. Populasi penelitian ini yaitu perusahaan yang terdaftar di Bursa Efek Indonesia periode tahun 2019-2020. Sampel ditentukan dengan teknik Purposive Sampling. Jumlah sampel penelitian ini yaitu 521 perusahaan. Teknik analisis data menggunakan wilcoxon signed-rank test. Data  diolah  memakai software SPSS versi  26. Hasilmya menunjukkan bahwa  terjadi perbedaan rasio likuiditas (current ratio), rasio solvabilitas (debt to asset ratio), rasio aktivitas (asset turnover ratio), rasio profitabilitas (return on assets dan return on equity) sebeum dan saat adanya pandemi covid-19 pada perusahaan yang terdaftar di BEI yang memenuhi kriteria sampel.
Analisi Pengaruh Biaya Kualitas Terhadap Produk Cacat (Studi Kasus Pada PT. XYZ Aspal Tahun 2018-2020)
Authors: Monica Shahnaz Safitri  , Choirul Anwar  , Indah Muliasari
Published: November 2022

Penelitian ini memiliki tujuan dalam menentukan dan menganalisis pengaruh biaya kualitas terhadap produk cacat pada PT. XYZ Aspal. Jenis penelitian menggunakan studi kasus dengan data didapatkan berdasarkan pada laporan keuangan dan wawancara terhadap manajemen PT. XYZ aspal. Sampel penelitian yang digunakan dalam penelitian diambil dengan berdasarkan produk yang memiliki jumlah produksi terbanyak dari 6 produk sebagai populasi dalam penelitian. Metode penelitian yang digunakan adalam metode campuran (mix method) dengan model explanatory sequential design. Metode kuantitatif dianalisis dengan aplikasi SPSS untuk menguji analisis regresi linier berganda. Analisis ini dilakukan untuk menguji hipotesis penelitian Selanjutnya dilakukan penelitian dengan mengunakan metode kualitatif dengan wawancara dan studi dokumentasi. Wawancara ditinjau berdasarkan persepsi manajemen PT. XYZ Aspal. Hasil penelitian ini menunjukkan bhawa: (1) Biaya pencegahan memiliki pengaruh negatif terhadap produk cacat, (2) biaya penilaian berpengaruh negatif terhadap produk cacat, dan (3) biaya kegagalan internal tidak mimiliki pengaruh terhadap produk cacat.
Pengaruh Faktor-Faktor Terhadap Struktur Modal Pada Perusahaan Non Keuangan Tahun 2020
Authors: Nugraha Dian Permana  , Ulupui I Gusti Ketut Agung , Rida Prihatni
Published: November 2022

Penelitian ini bertujuan untuk menguji secara empiris pengaruh struktur aktiva, profitabilitas,ukuran perusahaan dan cash holding terhadap struktur modal. Penelitian ini menggunakan data sekunder yang didapat dari Bursa Efek Indonesia pada perusahaan non keuangan yang terdaftar pada tahun 2020. Pemilihan sampel dilakukan dengan cara purposive sampling yang menghasil 126 perusahaan dari total populasi 613 perusahaan. Penelitian ini menggunakan analisi regresi linear berganda untuk menguji hipotesis dibantu dengan progam SPSS versi 25.Hasil penelitian ini menunjukan bahwa struktur aktiva dan ukuran perusahaan memiliki pengaruh positif terhadap struktur modal, serta profitabilitas dan cash holding berpengaruh negatif terhadap struktur modal.
Perancangan Sistem Informasi Akuntansi Penjualan Dengan Penekanan Security System Pada PT Berkat Orang Muda
Authors: Rizki Muharam Sururi  , Choirul Anwar  , Petrolis Nusa Perdana
Published: November 2022

Komoditas adalah suatu barang bersifat nyata dan mudah diperdagangkan, mampu diserahkan secara fisik, disimpan dalam kurun waktu tertentu serta ditukarkan dengan produk yang sejenis, biasanya dapat dibeli atau dijual oleh investor melalui bursa berjangka. Lini bisnis ini yang baru dijalankan oleh PT Berkat Orang Muda namun memiliki beberapa kendala, seperti pencatatan transaksi penjualan komoditas yang masih manual. Oleh karena itu, perusahaan membutuhkan sistem informasi akuntansi modern yang mampu menunjang penjualan komoditas agar lebih efektif dan efisien. Dengan pendekatan kualitatif research & development, penulis merancang sistem informasi akuntansi penjualan dengan penekanan security system. Perancangan ini diharapkan turut andil dalam mewujudkan pengendalian internal yang dilakukan perusahaan dengan efektif. Perancangan sistem dikembangkan dengan teknologi berbasis cloud computing untuk menyimpan data. Pengembangan sistem menggunakan metode System Development Life Cycle (SDLC) dengan model waterfall. Output dalam penelitian ini merupakan aplikasi sistem informasi akuntansi penjualan komoditas yang dirancang dengan bahasa pemrograman PHP untuk desain tampilan antarmuka dan SQL untuk pemodelan basis data.
Faktor-Faktor yang Mempengaruhi Perilaku Auditor dalam Situasi Konflik Audit
Authors: Moch. Farhan Fadilla  , Rida Prihatni  , Ayatulloh Michael Musyaffi
Published: November 2022

Studi ini dilaksanakan untuk mencari tahu terkait faktor-faktor dari Perilaku Auditor dalam Situasi Konflik Audit. Riset ini berfokus pada variabel Locus of Control, Sifat Machiavellian, Komitmen Profesional dan Pengalaman Audit yang dapat mempengaruhi Perilaku Auditor dalam Situasi Konflik Audit. Data primer digunakan untuk studi ini dengan auditor di KAP Jakarta Timur sebagai sampel. Teknik convienence sampling digunakan dalam proses pengumpulan data dengan responden sebanyak 34 auditor. Data yang digunakan kemudian diuji dengan model regresi berganda dengan bantuan aplikasi SPSS 25. Hasil pengujian mendapatkan bukti bahwa locus of control, sifat machiavellian, dan komitmen profesional tidak berpengaruh terhadap perilaku auditor dalam situasi konflik audit, sedangkan pengalaman audit berpengaruh positif signifikan terhadap perilaku auditor dalam situasi konflik audit. Studi selanjutnya diharapkan dapat memperoleh lebih banyak responden, tidak melaksanakan penelitian bersamaan dengan periode audit, menambahkan variabel lain yang relevan dan dapat menggunakan teknik wawancara untuk mendapatkan jawaban yang lebih mendalam.
Pengaruh TQM Terhadap Kinerja UMKM dengan Mediasi Keunggulan Bersaing
Authors: Desy Rahmawati  , Unggul Purwohedi  , Rida Prihatni
Published: November 2022

Penelitian ini memiliki tujuan untuk menguji dan menganalisis pengaruh Total Quality Management (TQM) terhadap kinerja UMKM, menguji dan menganalisis pengaruh TQM terhadap keunggulan bersaing, menguji dan menganalisis pengaruh keunggulan bersaing terhadap kinerja UMKM, serta menguji dan menganalisis pengaruh TQM terhadap kinerja UMKM dengan mediasi keunggulan bersaing. Metode penelitian menggunakan pendekatan kuantitatif dengan teknik pengambilan sampel non-probability sampling berupa purposive sampling. Data primer penelitian melalui pengumpulan kuesioner yang diperoleh dari total sampel sebanyak 70 Pemilik UMKM di Kecamatan Pademangan, Jakarta Utara. Penelitian menggunakan teknik analisis data berupa analisis statistik deskriptif dan analisis statistik inferensial melalui PLS-SEM pada SmartPLS 3.0. Hasil penelitian menyimpulkan bahwa (1) TQM secara signifikan memiliki pengaruh positif terhadap kinerja UMKM; (2) TQM secara signifikan memiliki pengaruh positif terhadap keunggulan bersaing; (3) Keunggulan bersaing secara signifikan memiliki pengaruh positif terhadap kinerja UMKM; serta (4) Keunggulan bersaing memediasi hubungan TQM terhadap kinerja UMKM secara signifikan memiliki pengaruh positif. Penelitian ini memberikan kontribusi terhadap hasil temuan yang didapatkan untuk penelitian yang sejalan dan memberikan kontribusi terhadap Resource Based View Theory dan Dynamic Theory of Strategy. Selain itu, penelitian ini memberikan implikasi terhadap Pelaku UMKM untuk bisa menerapkan sistem TQM dalam usaha agar mampu bersaing secara kompetitif yang dapat meningkatkan kinerja usaha.
Analisis Relevansi Nilai Informasi Akuntansi Terhadap Herga Saham dengan Penerapan PSAK 71 sebagai Pemoderasi
Authors: Dhery Shabrian Kurnia Alifiono  , Aisa Tri Agustini  , Oktaviani Ari Wardhaningrum
Published: November 2022

Penelitian ini bertujuan menganalisis bagaimana (1) pengaruh relevansi nilai laba terhadap harga saham(2) pengaruh relevansi nilai buku per lembar saham terhadap harga saham, dan (3) apakah dengan menerapkan PSAK 71 dapat memoderasi relevansi nilai laba dan relevansi nilai buku pada sektor perbankan yang listing di Bursa Efek Indonesia. Metode penelitian ini yang digunakan adalah metode kuantitatif. Sampel penelitian sebanyak 106 perusahaan sektor perbankan yang daftar di BEI tahun 2016-2020. Teknik analisis data yang digunakan adalah analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa relevansi nilai laba berpengaruh signifikan terhadap harga saham di sektor perbankan. Begitu juga halnya dengan relevansi nilai buku berpengaruh signifikan terhadap harga saham. Namun ketika relevansi nilai laba dan relevansi nilai buku dimoderasikan dengan PSAK 71 dengan menggunakan metode variabel dummy, belum mampu untuk memperkuat hubungan tersebut.
Pengaruh Good Corporate Governance (GCG), dan Corporate Social Responsibility (CSR) Terhadap Nilai Perusahaan Dengan Ukuran Perusahaan dan Leverage Sebagai Variabel Kontrol
Authors: Evi Irmalasari  , Etty Gurendrawati  , Indah Muliasari
Published: November 2022

Nilai perusahaan menjadi suatu hal yang penting karena dapat memberikan gambaran pertumbuhan perusahaan dan kinerja manajemen. Upaya yang dilakukan oleh manajemen dalam mengelola perusahaan akan meningkatkan keuntungan dan mengurangi risiko kerugian dimasa mendatang. Semakin tinggi nilai perusahaan maka pemegang saham perusahaan akan semakin sejahtera. Tujuan dalam penelitian ini adalah untuk melihat pengaruh Good Corporate Governance (GCG) dan Corporate Social Responbility (CSR) Terhadap Nilai Perusahaan dengan Ukuran Perusahaan dan Leverage sebagai Variabel Kontrol. Populasi dalam penelitian ini adalah perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2020. Dengan menggunakan metode purposive sampling menghasilkan sampel sebanyak 100 selama periode pengamatan. Teknik analisis data menggunakan random effect model. Data diolah dengan menggunakan eviews. Hasilnya menunjukkan bahwa dewan komisaris independen berpengaruh positif terhadap nilai perusahaan, sementara leverage berpengaruh negatif terhadap nilai perusahaan, sedangkan komite audit, csr, dan ukuran perusahaan tidak berpengaruh pada nilai perusahaan.
The Effect of Audit Tenure, Workload, and Company Size on Audit Quality
Authors: Divo Ridho Agustianto  , Adam Zakaria  , Dwi Kismayanti Respati
Published: November 2022

This study aims to determine the effect of audit tenure, workload, and firm size on audit quality. This study uses secondary data. The purposive sampling method was used as a sampling technique with 53 selected companies from all infrastructure, utilities, and transportation companies listed on the Indonesia Stock Exchange in 2018-2020. The data were processed by multiple linear regression and SPSS 25.0 program. The results of this study indicate that workload and firm size have a positive effect on audit quality. Meanwhile, audit tenure has no effect on audit quality.
Effect of Transverse Versus Longitudinal Incisions on Anterior Knee Pain After Tibial Nailing (TRAVEL)
Authors: Leliveld Mandala S. , Van Lieshout Esther M.M. , Polinder Suzanne , Verhofstad Michael H.J. ,   the TRAVEL Study Investigators
Published: November 2022

Background:

Anterior knee pain is common after tibial nailing, and its origin is poorly understood. Literature suggests it may be related to infrapatellar nerve injury. The aim of this study was to compare the effect of a transverse (potentially infrapatellar nerve-sparing) incision versus a longitudinal incision for the insertion of a tibial nail with respect to anterior knee pain.

Methods:

Patients with a tibial shaft fracture undergoing treatment with use of an intramedullary nail were randomized to a transverse incision (n = 68) or longitudinal incision (n = 68) in multiple centers. The primary outcome measure was kneeling pain based on a numeric rating scale (NRS). Secondary outcome measures included knee pain during daily activities, functional outcome (Short Musculoskeletal Function Assessment and Lower Extremity Functional Scale), quality of life (EuroQol-5 Dimensions), activity resumption, complications, reoperations, and costs within 1 year after trauma.

Results:

At 12 months, the estimated marginal mean for kneeling pain was 2.4 (95% confidence interval [CI], 1.6 to 3.2) in the transverse incision group and 3.7 (95% CI, 3.0 to 4.5) in the longitudinal incision group. Regression analysis showed no significant difference between the groups over time. Knee pain scores for daily activities, functional outcome scores, and quality of life were also comparable between the groups. Signs of infrapatellar nerve injury were found less often after a transverse incision (18% versus 54%; p < 0.001). The median total (direct and indirect) costs per patient were €10,468 in the transverse incision group and €11,066 in the longitudinal incision group. Loss of productivity accounted for 67% and 52% of the total costs in the 2 groups, respectively.

Conclusions:

A transverse incision reduces injury to the infrapatellar nerve, but anterior knee pain scores and function are comparable after use of a transverse or longitudinal incision for tibial nail insertion.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
A Rare Case of Twisted Ovarian Cyst in Term Gestation Patient
Authors:   Associate Professor, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule– 424001 Maharshtra, India., Kulkarni Nitin  N. , Shah Harshil P. ,   Resident, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule, Maharashtra 424002, India.
Published: November 2022

Introduction: Torsion of ovarian cyst is defined as total or partial rotation of adnexa around its vascular axis or pedicle. We may get difficulty in diagnosis in term gestation patient because of gravid uterus and symptoms of onset of labour mimicks the symptoms of twisted ovarian cyst. Method: Case Report 32 year G3P2L2 with 38 weeks of gestation with complain of pain in abdomen and nausea since previous day. H\O same complains twice in last month which was diagnosed as preterm labour pain and treated accordingly in other hospital. She presented herself in latent phase of labour. During monitoring, she was having continuous abdominal pain and episodes of vomiting twice. Decision of emergency L.S.C.S taken in view of fetal distress and non progress of labour. But while exploring the abdominal cavity, twisted ovarian cyst of size 10 x 8 cm in right adnexa found. Right sided Salpingoophorectomy done without untwisting the pedicle. Conclusion: Twisted ovarian cyst is usually symptomatic in pregnancy. but here because of Gravid Uterus, It remained undiagnosed till term gestation and required right salpingoophorectomy during L.S.C.S.
Calcium: Nutrient in Adolescent Girls
Authors:   Professor & H.O.D, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule, Maharashtra 424002, India., Patil Alka , Kulkarni Nitin ,   Associate Professor, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule, Maharashtra 424002, India., Patil Rahul V. ,   Junior Resident, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule, Maharashtra 424002, India.
Published: November 2022

Bone health is important to health and quality of life. It is important to optimize bone health throughout life cycle. Adolescence is a transitional journey from childhood to adult life along with physical development. This may be considered as physical, psychological and emotional rebirth. Nutrition in adolescence has preventive role related to diet causing chronic diseases like cardiovascular disease, cancer and osteoporosis. Diet and physical factors play a major role in promoting bone health, which begins in childhood and continues into old age. Calcium and protein in the diet with sunlight exposure and weight bearing exercises are important for building the peak bone mass in adolescents. Calcium as nutrient in adolescence is critical for prevention of osteoporosis and improving quality of life.
Comparación de tres metodologías para la estimación de la abundancia del manatí amazónico (Trichechus inunguis) en el Área de Conservacción Regional "Comunal Tamshiyacu Tahuayo" (ARC CTT), provincia Maynas-Loreto
Authors:   , Oshita Tello Ayumi
Published: November 2022

El manatí amazónico (Trichechus inunguis) es endémico del río Amazonas, con una limitada información de la dinámica poblacional y actualmente enlistado como Vulnerable UICN. El presente estudio tiene como objetivo comparar tres metodologías: observación directa (OD), tecnología del sonar de barrido lateral (SBL) y encuestas hacia comunidades locales; para estimar la abundancia del manatí amazónico y realizar cabo un análisis comparativo de las experiencias presentadas en cada metodología cuando son aplicadas en hábitats complejos. El estudio fue llevado a cabo dentro del Área de Conservación Regional Comunal Tamishiyacu Tahuayo en Iquitos, Perú. La OD resultó en cero avistamientos en ambas estaciones luego de un esfuerzo de muestreo de 30 y 34 horas en la estación creciente y vaciante respectivamente. Tras el uso del SBL, dos individuos se registraron en agosto, luego de un recorrido total de 103,38 km en la estación vaciante. Las encuestas realizadas a los pescadores artesanales en tres comunidades aledañas indicaron una reducción en avistamientos en el área protegida. Se discute las ventajas y desventajas de cada metodología, la logística asociada a su uso en hábitats complejos, y su efectividad y uso potencial para manatíes y otros mamíferos acuáticos poco estudiados.
Decoding coaching: how metacognitive strategy-based training program effects on coaches’ self-regulation skills?
Authors: Sabaliauskas Stanislav , Gražulis Donatas , Žilinskienė Nelė , Kaukėnas Tomas
Published: November 2022

Self-regulation is not only as a feature, but also as a process that learners use to control and organize their thoughts and turn them into skills used in learning. Self-regulated learning relies on the activation and use of metacognitive skills. Metacognitive strategies help learners to become aware of their thinking processes during learning. Self-regulation skills are significant when operating in difficult or extreme conditions that requires effort. Conscious observation and reflection enable to improve personal metacognitive skills and significantly contribute to changing behaviour, that is, to improving self-regulation processes.
The aim of this research is to assess the impact of a metacognitive strategy-based training program on coaches’ self-regulation skills. A mixed methods study was chosen for the research. The facilitation program for improving self-regulation skills had a positive impact on coaches’ self-regulation skills. At the end of the program, the total self-regulation index of the coaches increased.
The training programme based on metacognitive questioning allowed for enhancing self-regulation skills of experienced coaches. Self-reflection and implementation of metacognitive strategies influenced coaches’ cognition, thinking competences and behaviour. The coaches’ behaviour manifested itself in curiosity and openness to innovation, recognition of otherness, broadening of the horizons, awareness of complexity and disclosure of connections.
Bio and electronically controlled surface plasmons polaritons generated by coupling between nano-antenna and photosynthetic protein - photosystem I
Authors: Carmeli Itai , Tanriover Ibrahim , Malavath Tirupathi , carmeli chanoch , Cohen Moshik , Abulafia Yossi , Girshevitz Olga , Richter Shachar , Aydin Koray , Zalevsky Zeev
Published: November 2022

Surface plasmons polaritons (SPP) hold great promise for the next generation of fast nanoscale optoelectronic devices, as silicon-based electronic devices approach fundamental speed and scaling limitations. However, in order to fully exploit the potential of plasmonics, devices and material systems capable of actively controlling and manipulating plasmonic response is essential. Here, we demonstrate active control of the electric field distribution of a micro antenna by coupling SPP to a photosynthetic protein with outstanding optoelectronic properties and long range and efficient exciton transfer ability. The hybrid bio-solid state active platform is able to tune and modulate the optical activity of a micro plasmonic antenna via interaction of the bioactive material with plasmon oscillations occurring in the antennae. In addition, we demonstrate that the effect of the coupling can be further enhanced and controlled by an external potential applied to the micro antenna Photosynthetic hybrid system.
Safety and Efficacy of Posterior Scleral Application of Mitomycin C-Soaked Sponge in Trabeculectomy
Authors: Hu Kun , Song Yunhe , Lin Fengbin , Zhang Yingzhe , Jin Ling , Liang Mengyin , Weinreb Robert , Zhang Xiulan
Published: November 2022

Background/Objectives: To evaluate the safety and efficacy of posterior scleral application (a modified technique) of antimetabolite mitomycin C (MMC)-soaked sponge in trabeculectomy for patients with glaucoma.
Subjects/Methods: A total of 101 patients (115 eyes) with glaucoma, aged 12–83 years who underwent trabeculectomy using a modified MMC-soaked sponge placement method were enrolled in this observational study. The sponge was placed vertically and posteriorly with the long side perpendicular to the limbus. The MMC concentration was 0.2–0.5 mg/ml and the exposure time was 1–5 min. The intraocular pressure (IOP), best-corrected visual acuity, and the number of hypotensive medications taken at baseline and at the final visit were recorded. Complications, interventions required, and bleb morphology were recorded postoperatively. Bleb morphology, including height, extent, vascularity, Seidel test, and width, was graded using the Indiana Bleb Appearance Grading Scale. The primary outcome was the safety of trabeculectomy including complications and bleb morphology. The secondary outcome was the success rate of trabeculectomy.
Results: The median follow-up period was 28 months. At the final follow-up, the qualified (cumulative) success rate was 93.0% and the complete success rate was 60.0%. No bleb-related complication was observed. The mean height was 0.6 ± 0.9. The mean extent was 1.2 ± 0.4. The mean vascularity was 2.4 ± 0.9. All Seidel tests were negative. The mean width was 0.8 ± 0.4.
Conclusions: Trabeculectomy with the long side of the MMC-soaked sponge placed perpendicular to the corneal limbus to maximise the exposure area is safe and effective.
Evaluation and pilot testing of a multidisciplinary model of care to mainstream genomic testing for paediatric inborn errors of immunity
Authors: Yanes Tatiane , Sullivan Anna , Barbaro Pasquale , Brion Kristian , Hollway Georgina , Peake Jane ,   Peter McNaughton1
Published: November 2022

Molecular diagnosis of paediatric inborn errors of immunity (IEI) influences management decisions and alters clinical outcomes, through early use of targeted and curative therapies. The increasing demand on genetic services has resulted in growing waitlists and delayed access to vital genomic testing. To address this issue, the Queensland Paediatric Immunology and Allergy Service, Australia, developed and evaluated a mainstreaming model of care to support point-of-care genomic testing for paediatric IEI. Key features of the model of care included a genetic counsellor embedded in the department, state-wide multidisciplinary team meetings and variant prioritisation meetings to review whole exome sequencing (WES) data. Of the 62 children presented at the MDT, 43 proceeded to WES, of which nine (21%) received a confirmed molecular diagnosis. Changes to treatment and management were reported for all children with a positive result, including curative hematopoietic stem cell transplantation (n = 4). Four children were also referred for further investigations of suspicious variants of uncertain significance or additional testing due to ongoing suspicion of genetic cause after negative result. Demonstrating engagement with the model of care, 45% of the patients were from regional areas and on average, 14 healthcare providers attended the state-wide multidisciplinary team meetings. Parents demonstrated understanding of the implications of testing, reported minimal decisional regret post-test and identified benefits to genomic testing. Overall, our program demonstrated the feasibility of a mainstreaming model of care for paediatric IEI, improved access to genomic testing, facilitated treatment decision-making, and was acceptable to parents and clinicians alike.
Severe lung dysfunction and pulmonary blood flow during extracorporeal membrane oxygenation
Authors: Falk Lars , Lidegran Marika K. , Ruiz Sandra Diaz , Hultman Jan , Broman Lars Mikael
Published: November 2022

Background: Extracorporeal membrane oxygenation (ECMO) is indicated for patients with respiratory and/or circulatory failure. The standard technique to visualize the extent of pulmonary damage during ECMO is computed tomography (CT).
Purpose: This single centre retrospective study aimed to investigate whether pulmonary blood flow (PBF) measured with echocardiography may assist in the assessment of the extent of pulmonary damage and whether echocardiography and CT findings are associated with patient outcome.
Methods: All patients (>15 years of age) commenced on ECMO between 2011 and 2017 with septic shock with a pulmonary origin, and a treatment time >28 days were screened. Of 277 eligible patients, nine were identified where both CT and echocardiography had been consecutively performed.
Results: CT failed to indicate any differences in viable lung parenchyma within or between survivors and non-survivors at any time over the course of ECMO. At initiation of ECMO the survivors (n=5) had a mean PBF of 3.8 L/min and the non-survivors (n=4) 3.5 L/min, p=0.78. Survivors showed no change over time concerning PBF (3.8±2.1 at ECMO start vs. 7.9±4.3 L/min at the end of treatment, p=0.12). The non-survivors showed a significant deterioration in PBF from the ECMO start to the end of support (3.5±1.0 L/min vs. 1.0±1.1, respectively, p=0.029).
Conclusions: Although CT is widely used to examine pulmonary viability and recovery, our results do not support CT as a prognostic tool. However, this hypothesis-generating investigation supports echocardiography as a tool to predict pulmonary recovery via assessment of PBF at early to later stages of ECMO treatment. Prospective studies are needed.
Study and Research of Milky Shine on the Surface of Zisha Pot by Microscopy Imaging
Authors: Yadav Nagendra Prasad , Hu Guozhen
Published: November 2022

Optical imaging has offered unique advantages in material research, such as spectroscopy and lifetime measurements of deeply embedded materials, which cannot be matched using electron or scanning probe microscopy. The first special quality that makes Zisha teapots esteemed and collectible items for tea lovers are that it is an especially absorbent material. Many efforts have been made by researchers to improve the optical imaging resolution. In the face of recent rapid progress, super-resolution optical imaging has yet to be widely applied to non-biological materials. Herein we describe a method for Milky Shine on the Surface of Zisha (Yixing) Pot by Super-Resolution Parameter Indirect Microscopy Imaging. Further, we have seen that the surface resolution of PIMI images is better than a conventional image. Zisha ceramics is a distinctive pottery tradition unique to China. PIMI images of Zisha pot has been reportred and resolution is near about 50nm, which is much better than conventional images.
DGKζ deficiency promotes maladaptive cardiac hypertrophy through modulating autophagy via mTOR/TFEB signaling pathway
Authors: Liu Yumei , Zhang Han , Lin Yaxian , Yin Yuan , Zou Ganglin , Qian Peipei , Zhang Haining , Zhang Jinxin
Published: November 2022

The activation of diacylglycerol (DAG) signaling by Gq protein-coupled receptor (GPCR) is a crucial factor contributing to maladaptive cardiac hypertrophy. Previous studies showed that diacylglycerol kinase zeta (DGKζ) suppressed cardiac hypertrophy by attenuating DAG signaling. However, the mechanisms involved remain to be elucidated. In present study, we showed that DGKζ ameliorated adverse cardiac hypertrophy induced by DAG signaling through negatively regulating autophagy. We demonstrated that sustained activation of DAG signaling by transverse aortic constriction (TAC) in mice or by endothelin (ET)-1 in cardiomyocytes triggered progressive cardiac hypertrophy, cardiac dysfunction and ultimately heart failure. In response to prohypertrophic challenge, autophagy activity was markedly upregulated. Importantly, we found that the persistent upregulation of autophagy flux by rapamycin aggravated the long-term adverse cardiac hypertrophy and dysfunction. While all of which could be ameliorated by inhibition of autophagy by CQ or 3-MA. Furthermore, we observed that expression of DGKζ was significantly downregulated both in TAC mice heart and in ET-1-treated cardiomyocytes. Specific gene deletion of DGKζ augmented autophagy flux by disrupting the activation of AKT/mTOR signaling, the association between mTOR and TFEB, and favoring the nuclear translocation of TFEB from cytoplasm and the nuclear accumulation of TFEB. Of note, knockdown of TFEB blunted the effects of DGKζ deletion on cardiac autophagy and cardiac hypertrophy. Taken together, these results suggested that regulating autophagy via mTOR/TFEB signaling pathway might be a novel mechanism for DGKζ to ameliorate pathological cardiac hypertrophy.
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease
Authors: Xia Zengjie , Prescott Emily , Wareing Hollie , Matuszyk Martyna , Dakin Helen , Dimou Eleni , Hidari Eric , Zhang Yu , Lam Jeff , Danial John , Leah Tom , Barnes Katy , Jiang Hong , Strickland Michael , Thornton Peter , Crowther Damian , Holtzman David , Bell Simon , Higginbottom Adrian , Ferraiuolo Laura , Mortiboys Heather , Wharton Stephen , Ranasinghe Rohan , Klenerman David , De Suman
Published: November 2022

Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all isoforms of apoE associate with Aβ in the early stages of aggregation and then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ~ 50% of the mass of soluble Aβ aggregates detected in the frontal cortices of homozygotes with the higher-risk APOE4 gene. Our results connect inherited APOE genotype with the risk of developing AD by demonstrating how, in an isoform- and lipidation-specific way, apoE modulates the aggregation, clearance and toxicity of Aβ. Selectively removing non-lipidated apoE4-Aβ co-aggregates enhances clearance of toxic Aβ by glial cells, and reduces inflammation and membrane damage, demonstrating a clear path to AD therapeutics.
Medical records and multiple sclerosis: A population-based case–control study
Authors: esfandiari Fatemeh , Ghazaiean Mobin , Darvishi-Khezri Hadi , Baghbanian Seyed Mohammad
Published: November 2022

Background
Medical records on multiple sclerosis progression is not complete. This study aimed to review the medical records and sociodemographic findings of the multiple sclerosis population in Mazandaran province.
Method
This case-control study included cases and two groups of patient control and healthy control groups (n=200 per group). Multivariable analysis was used to calculate odds ratios and 95% confidence intervals (CI).
Result
The participants’ mean age was 36.5 ± 11.9 years, and there were 381 (63.5%) female cases in this study. According to adjusted odds ratios, the highest and the lowest roles for the multiple sclerosis progression included measles (4.40; 95% CI: 1.73 to 11.1), psoriasis (4.63; 95% CI: 0.35 to 60.6), myasthenia gravis (7.15; 95% CI: 1.87 to 27.2) and amoxicillin (4.75; 95% CI: 2.05 to 11), seizure (0.14; 95% CI: 0.03 to 0.69), and epilepsy (0.17; 95% CI: 0.02 to1.49).
Conclusion
Myasthenia gravis and seizure had the highest and lowest association with multiple sclerosis, respectively. Hence, this study implied that autoimmune diseases were more frequently correlated with the multiple sclerosis progression.
Preparation and Properties of Flexible Cushioning Composites Based on Silicone Rubber and Warp - knitted Spacer Fabric
Authors: Jiang Shan , Ding Modan , Chen Weilai , Wang Jinfeng
Published: November 2022

This paper aims to develop a new type of flexible cushioning composite material that can be applied to cushioning protective appliances. Room temperature vulcanized silicone rubber (RTV silicone rubber) was filled into five groups of warp knitted spacer fabrics with different structural parameters, and flexible cushioning composites with filling rates of 30%, 50% and 70% were prepared. At the same time, there was a group of warp knitted spacer fabrics without silicone rubber as control. Then the infrared spectrum of silicone rubber was analyzed to test the compression and impact properties of flexible cushioning composite. It is found that the increase of filling rate enhances the compressive and impact properties of flexible cushioning composites. The flexible cushioning composite material can show better compression performance at a larger compression ratio; the compression performance is not related to the spacing density of the fabric. The structural parameters affecting the impact properties of flexible cushioning composites are arranged in descending order as fabric thickness, spacer tilt angle, spacer density and spacer diameter. The established mathematical model can provide a theoretical basis for the performance study of such composite materials. The compressive properties and impact properties of flexible buffer composites are not correlated.
Comparison of Cross-lingual Strategies for AMR-to-Brazilian Portuguese Generation
Authors: Cabezudo Marco Antonio Sobrevilla , Anchiêta Rafael Torres , Pardo Thiago Alexandre Salgueiro
Published: November 2022

This work presents a study of different strategies for tackling low-resource AMR-to-text generation for Brazilian Portuguese on three approaches. In particular, we explore the use of English AMR as an interlingua and transfer learning (TL). The results suggest that using AMR as an interlingua can be a strong baseline. However, we need to consider the bilingual dictionary used in the concept translation, as it can harm text generation. On the other hand, TL seems to be a promising strategy for generating accurate outputs, but its contribution is not significant. Finally, we present a transformer-based model with the best performance, surpassing all baselines.
Molecular phylogeny, character evolution, and biogeography of Aster species (Asteraceae) from the Qinghai-Tibet Plateau
Authors: Wang Junjun , Zhang Yingxiu , Zhao Riza , Lei Yingxia , Zhang Zhifeng
Published: November 2022

Background
The genus Aster on the Qinghai-Tibet Plateau is an important part of its ecosystem. In this study, 94 accessions of Astereae species (including 25 taxa from the Qinghai-Tibet Plateau) were included for the phylogenetic analyses using nrDNA ITS and cpDNA trnL-F sequences. Then, based on the phylogenetic analysis results of Bayesian method, the chart of network topology, the graph of divergence time, the map of biogeography and the figure of ancestral state reconstruction (including the number of ray florets, number of pappus and number of bracts.) were constructed.
Results
(1)Phylogenetic analysis of the ITS gene showed that Astereae species in Qinghai-Tibetan Plateau were divided into two branches, but the analysis result of the trnL-F gene showed that they were clustered in one branch. (2)Molecular dating estimated that the divergence time of Astereae species in Qinghai-Tibet Plateau could be dated back to 2.02 Ma. (3)The ancestral state of Astereae species was reconstructed, and the results showed that the trait evolution in the Qinghai-Tibet Plateau region was different from that in other regions. (4)Biogeography results showed that Aster species in the Qinghai-Tibet Plateau were mainly from Eurasia.
Conclusion
This study provides a scientific basis and reference for the genetic relationship of Aster species and related genera.
Identification of Common Genes and Screening of Therapeutic Agents for Major Depressive Disorder and Alzheimer's Disease through Integrated Bioinformatics Approach
Authors: Xie Mengtong , Jin Mengdi , Li Xinwei , Hu Guoyan , Li Weizhen , Dong Lin , Xue Fengyu , Yu Qiong
Published: November 2022

Objective

To investigate the interactions between major depressive disorder(MDD) and Alzheimer's disease(AD) through bioinformatics to detect biomarkers that contribute to the onset and progression of MDD and AD, so as to allow for immediate intervention and treatment.

Methods

MDD dataset GSE98793 and AD dataset GSE63060 were obtained from the Gene Expression Omnibus(GEO) database. Identification of common differential genes(DEGs) in both datasets, followed by GO and Pathway analysis, then constructing protein-protein interaction(PPI) networks, identifying hub genes and validating with the GSE63061 dataset. TF-gene and gene-miRNA interactions networks were then constructed and potential therapeutic agents were identified.

Results

Totally 31 common DEGs were identified. GO analysis revealed that these DEGs were enriched in cytoplasmic translation, fructose-2,6-bisphosphate 2-phosphatase activity, tertiary granule lumen. Additionally, Pathway analysis enriched in the Cytoplasmic Ribosomal Proteins, Ribosome, Viral mRNA Translation and TSP-1 Induced Apoptosis in Microvascular Endothelial Cell. By structuring PPI network, 10 hub genes were identified, and 9(RPS3A, RPS15A, RPL9, NDUFA4, RPS17, CD3D, GZMA, S100A12, KLRB1) were validated. Through the NetworkAnalyst platform, TFs(GTF2E2, FOXJ2, CREB3L1, TFDP1, SAP30), miRNAs(mir-16-5p, mir-1-3p, mir-124-3p, mir-7-5p, mir-146a-5p) and chemicals(Aflatoxin B, Benzo(a)pyrene, Estradiol, Valproic Acid, Nickel) interacting with common DEGs were identified. Through Enrichr platform, drugs including aspirin, medroxyprogesterone acetate, p-Phenylenediamine, COBALT, sodium dodecyl sulfate were identified. Additionally, totally 53 effective drugs were identified through the Drug-Gene Interaction Database.

Conclusion

Overall, these hub genes, TFs, and miRNAs may represent potential diagnostic and therapeutic targets for MDD and AD, and these agents may provide fresh insights and alternatives for the treatment of MDD and AD.