bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysing Growth Trend, Profitability and Resource Use Efficiency of Summer Mungbean in Eastern Haryana
Authors: Kumar Mandeep , Malik D.P. , Dixit A.K. , Nimbrayan Parveen Kumar , Bedwal Sandeep , Rawal Sagar
Published: July 2024

Background: Mungbean [Vigna radiata (L.) Wilczek] is the most extensively sown crop among commonly produced Asiatic Vignas, viz., urdbean, mungbean, mothbean, ricebean and azukibean. In Haryana, the crop covered 28.5 thousand ha area with annual production of 19.6 thousand tonnes having productivity of 688 kg ha-1 in 2020-21. To prevent the perils of mono-cropping (paddy-wheat system) in the state, there is a need for deep transformation through inclusion of pulses like summer mungbean, in the existing cropping system. Hence, the present investigation critically examines the growth trends, economics and efficiency of resource use in summer mungbean cultivation in eastern zone of the state. Methods: This study uses both primary and secondary source of data. The primary data was collated from 80 summer mungbean growers using multi-stage random sampling technique. The secondary data was retrieved from various published and unpublished sources for a period of 30 years from 1991-92 to 2020-21. For measuring the growth trends and instability in the area, production and productivity of mungbean, compound annual growth rate (CAGR) and Cuddy-Della Valle index (CDVI) were computed. Simple budgeting technique was employed for calculating the economics of summer mungbean. For resource use efficiency, Cobb-Douglas production function was used. Result: The results show a positively significant growth rate in mungbean area, production and productivity but with irregular trends. The instability in mungbean production is more pronounced in Haryana than India and is mainly attributed to area instability, while it is because of productivity instability at the country level. The mungbean is a profitable enterprise in summer season as the net returns realized to the tune of ₹ 26024 ha-1 with benefit-cost ratio of 1.43 in the study area. Further, the efficiency of resourceuse in summer mungbean exhibits increasing returns to scale. Hence, the inclusion of mungbean cultivation in summer season is profitable.
La unidad léxica pedo desde una perspectiva fraseológica en el argot mexicano y colombiano
Authors: Contreras Roa André Runné
Published: July 2024

El español posee innumerables variantes asociadas a distintas culturas y grupos sociales, la mayoría de estas originarias de países latinoamericanos. Estas variantes son evidentes en las particularidades lingüísticas de cada región, especialmente en la formación de lenguajes especializados y argots, es por esto por lo que en este artículo se examinó un corpus lingüístico de la variante mexicana que consta de 15 unidades fraseológicas con la partícula pedo, las cuales se extrajeron de una base de datos de 1945 unidades fraseológicas y recopiladas por el Grupo de Investigación Léxico Internacional y Colombiano (LEXICOL). Dentro de las tipologías abordadas se encuentran locuciones verbales, adjetivales y sustantivales. Posteriormente, se determinaron los rasgos semánticos y pragmáticos de estos constructos, para contrastarlos con variantes similares del español colombiano. Este análisis permitió establecer ciertas semejanzas en los significados de las unidades fraseológicas de los dos países, distinguir su funcionalidad discursiva según el contexto de uso y señalar sus limitaciones desde un plano pragmático, resultado de las situaciones de habla más comunes.
Pengaruh Inflasi, Nilai Tukar, dan Suku Bunga terhadap Indeks Demokrasi Indonesia pada Tahun 2009—2020
Authors: Ramdhani Hilal
Published: July 2024

Demokrasi merupakan tren global yang banyak diterapkan oleh berbagai negara dunia ketiga, termasuk Indonesia. Transisi dari sistem pemerintahan yang tidak demokratis, menjadi sistem pemerintahan yang demokratis memunculkan berbagai tantangan, terutama dari fluktuasi ekonomi yang merupakan bagian penting bagi kehidupan berbangsa dan bernegara. Masih sedikitnya penelitian yang menggunakan paradigma positivistik berakibat pada belum terungkapnya kajian yang bersifat sebab-akibat terhadap naik dan turunya indeks demokrasi Indonesia yang disebabkan oleh fluktuasi makroekonomi. Penelitian ini menggunakan pendekatan kuantitatif dengan metode ex post facto. Data penelitian menggunakan inflasi, nilai tukar, suku bunga, dan indeks demokrasi Indonesia selama 12 tahun dari tahun 2009-2020. Hasil penelitian menunjukkan bahwa model penelitian ini secara simultan berpengaruh terhadap indeks demokrasi Indonesia sebesar 79%, secara parsial menunjukkan inflasi tidak berpengaruh terhadap indeks demokrasi Indonesia, nilai tukar menunjukkan pengaruh positif terhadap indeks demokrasi Indonesia, dan suku bunga Bank Indonesia tidak berpengaruh terhadap indeks demokrasi Indonesia. Hal ini menandakan bahwa kenaikan dan penurunan nilai tukar berpengaruh pada indeks demokrasi Indonesia, sehingga penting bagi pemerintah untuk dapat menjaga stabilitas nilai tukar Indonesia, karena semakin tinggi nilai tukar maka semakin tinggi pula indeks demokrasi Indonesia.
Improving Students Learning Activeness in Social Studies Subjects through Student Teams Achievement Division (STAD) Cooperative Learning Model
Authors: Rohman Farrij Andika , Imam Khairi Ahmad , Devi Bernadetta
Published: July 2024

This research is motivated by the problems found in class VII E at SMPN 2 Pamekasan, namely the low level of student learning activeness in social studies lessons, in the classroom the teacher still uses the lecture method in explaining the learning material and continued with practice questions, as a result learning activities become unvaried and limited. cooperative learning model type Student Teams Achivement Division (STAD) is used to increase student activeness. This research used classroom action research (PTK) which was carried out in two cycles, each cycle consisting of four stages, namely the planning, implementation, observation, and reflection stages. The subjects of this study were students of class VII E consisting of 32 students. The research instruments used in this study were observation guidelines for student learning activeness, and field notes. While the data collection techniques used in this research are participatory observation, interviews, and documentation. The data analysis used is qualitative data analysis, which consists of data reduction, data presentation, and conclusion drawing, and quantitative data analysis with a percentage of the assessment of student learning activeness in the application of the Student Teams Achivement Division (STAD) type cooperative learning model.
Based on the results of the study it can be concluded that there is an increase in student learning activeness in social studies learning from cycle I to cycle II. Indicators pay attention to the teacher's explanation increased 12.51% from cycle I to cycle II. Indicators record or summarize the subject matter increased 28.13% from cycle I to cycle II. Indicators asking questions to teachers or friends experienced an increase of 26.57% from cycle I to cycle II. Indicators answering questions from teachers or friends increased 39.06% from cycle I to cycle II. Indicators discussing with group members in solving problems increased 21.88% from cycle I to cycle II. Indicators helping fellow group members in understanding the subject matter increased 14.07% from cycle I to cycle II. The indicator of doing tasks given by the teacher increased 28.12% from cycle I to cycle II. The indicator of doing quizzes individually increased 39.06% from cycle I to cycle II. And student learning activeness showed a score of 93.75% at the end of the cycle.
Mekanisme Pengelolaan dan Pengawasan Wakaf Saham Di Indonesia dan Malaysia
Authors: Apriyani Finna , Moh Khamim  , Moh Taufik
Published: July 2024

In Indonesia and Malaysia, a new form of waqf has developed, namely stock waqf. However, many people still do not know about the implementation of waqf shares. In the implementation of stock waqf, management and supervision challenges need to be overcome in order to increase its effectiveness. This study aims to (1) To examine the mechanism of management and supervision of waqf shares in Indonesia and Malaysia (2) To examine the differences and similarities of management and supervision in Indonesia and Malaysia. The type of research used is literature, the approach used is normative, data collection techniques using literature study analysis and using qualitative methods. The results of this research show that Indonesia and Malaysia in the implementation of waqf shares give their trust to nazhir as the only holder who manages and supervises waqf shares. in managing waqf shares, nazhir works with investment advisors.  Based on the results of this research, it is expected that it will become information and input for students, academics, practitioners, and all parties who need information in the environment of the Faculty of Law, Pancasakti University Tegal and the wider community.
PERNIKAHAN SAKINAH MAWADDAH WARAHMAH BAGI PENYANDANG TUNANETRA (STUDI KASUS KAMPUNG TUNANETRA KECAMATAN ILIR TIMUR 2 PALEMBANG)
Authors: Afriyani Silfa , Huzaimah Arne , Napisah Napisah
Published: July 2024

A marriage aims to create a sakinah, mawaddah, warahmah household life. From this goal it becomes a desire for every married couple, as well as for blind couples. So this research the authors formulate the problems, namely: (1) how to understand the family sakinah, mawaddah, warahmah for blind couples (2) how are the efforts to form a sakinah, mawaddah, warahmah household for blind couples.
This research method uses field research methods (field research), the data sources used are primary data sources obtained from interviews with respondents in the field, then secondary data obtained from books and scientific papers. Data collection techniques are direct interviews, field survey and documentation. The data analysis used was qualitative inductive, namely drawing conclusions from general statements drawn to specific statements.
From the results of the research that has been done, it can be concluded that: (1) Understanding the sakinah, mawaddah, warahmah family for blind couples is a family that is peaceful, peaceful, gives love to all family members, is always grateful to Allah SWT, can solve problems by well and of course support each other. (2) As for how to form a sakinah, mawaddah, warahmah family, namely by promoting a sense of love and affection between family members, understanding each other, understanding, appreciating, not demanding more of each other, establishing good communication, and always solving problems by giving in to each other. so that things that are not desirable happen.
Key words: Visually impaired, family, sakinah mawaddah warahmah
ANALISIS PENERAPAN ASAS GUGATAN KURANG PIHAK (PRULIUM LITIS CONSORTIUM) SEBAGAI ALASAN HAKIM MENOLAK GUGATAN WARIS (Studi Putusan Nomor 0735/Pdt.G/2015/PA.Bgr)
Authors: Ariansyah Jeri , Rochmiatun Siti , Ifrohati Ifrohati
Published: July 2024

Religious Courts, as seeking justice for interested parties, in legal parties that are often encountered regarding war lawsuits. The judge is of the opinion that all heirs must be included in the inheritance lawsuit as subjects. In the case of inheritance, an error occurred in the investigation regarding the parties involved in the Religious Courts. an error in the inheritance lawsuit so that the lawsuit cannot be accepted by the judg(prulium litis consortium).
          Type of research library research, using a conceptual and legal approach. Types of data from qualitative data, legal materials: primary law, secondary law, and tertiary law. Qualitative descriptive analysis technique.
The subject in the case of inheritance of decision 0735/Pdt.G/2015/PA.Bgr there are 3 heirs, parties in the case are only the first child as defendant, the third child as plaintiff. In addition, there are parties who should be included in lawsuit as co-defendants who control the inheritance because of the ownership rights by way of buying and selling between the first child as the seller, and the third party as buyer. application of the prulium litis consortium principle that judge has erroneously applied this principle so that the second heir who will be appointed as a co-defendant.
Key words: Prulium Litis Consortium, Heirs, Religious Court
Keterlibatan Multistakeholders dalam Mengembangkan Produktivitas dan Daya Saing Industri Kreatif Berbasis Pariwisata
Authors: Risty Fiksy Indah Nurani
Published: July 2024

Creative economy and tourism industry are two things that influence each other and can synergize if managed properly. Tourism-based creative industry is one of the creative economy sectors that has great potential for development in Indonesia. Opportunities for the creative industry across Indonesia have become widely open as an impact of diversity in arts, culture and cultural heritage. However, its development requires the roles and involvement of various stakeholders or multi-stakeholders. Stakeholders are individuals or groups involved in tourism development. In tourism destination management efforts, stakeholders are one of the important factors in maintaining competitiveness. This is the main factor in facing the dynamics and development of tourism markets. The aim of this study is to analyse the involvement of roles among stakeholders in improving productivity and competitiveness of tourism-based creative industries. The research method uses a qualitative approach. Multi-stakeholder involvement plays a significant role in developing productivity and competitiveness of tourism-based creative industries. Various stakeholders such as government, non-government organizations, industry players, and local communities contribute to various aspects of creative industry development. Based on these results, the implications are the need to strengthen cooperation between stakeholders, empower local communities, promote innovation and collaboration, and develop stakeholder capacities to improve productivity and competitiveness of tourism-based creative industries.
Jejak Poskolonial dalam Novel William Karya Risa Saraswati
Authors: Ramadhani Farisa Riski
Published: July 2024

Dalam penelitian ini disajikan mengenai kajian poskolonial atas teori orientalisme milik Edward W. Said dan teori dunia ketiga (Third Space) milik oleh Homi K. Bhabha yang mendeskripsikan adanya hegemoni, hibriditas, serta diskriminasi dalam novel William karya Risa Saraswati. Tujuan dari penelitian ini adalah untuk mengetahui kajian poskolonial atas teori orientalisme dan kemunculan dunia ketiga melalui hegemoni, hibridits, serta diskriminsi dalam novel William karya Risa Saraswati. Data penelitian diperoleh melalui novel William karya Risa Saraswati yang diterbitkan pada tahun 2017 yang berupa kata, frasa, dan kalimat. Penelitian ini merupakan penelitian kualitatif, melalui landasan teori sebagai acuam pembahasan dari hasil penelitian sebab peneliti ingin mengetahui lebih dalam kajian poskolonial atas teori orientalisme dan kemunculan dunia ketiga melalui keberadaan hegemoni, hibriditas, serta diskriminasi dalam novel William karya Risa Saraswati. Hasil penelitian ini menunjukkan kajian poskolonial atas teori orientalisme dan kemunculan dunia ketiga meliputi: (1) hegemoni kekuasaan bangsa Belanda terhadap Indonesia, (2) hibriditas yang terkandung dalam novel, serta (3) adanya diskriminasi dari Belanda sebagai bentuk cemoohan bangsa barat atas kekuasaan besarnya di era kolonial.
Study of Microstructure, Morphology and Functional Groups of Titanium Dioxide (Tio2) Impregnated With Copper (Cu)
Authors: Asmin La Ode , Isa La
Published: July 2024

This research aims to determine the differences in the microstructure, morphology, and functional groups of TiO2 (P-25) after being impregnated with Cu. Cu-impregnated TiO2 samples are synthesized using the impregnation method with TiO2 (P-25) and copper sulfate as precursors. The microstructure and functional groups of TiO2 (P-25) and Cu-TiO2 were investigated using X-ray diffraction (XRD), scanning electron microscope-energy dispersive x-ray (SEM-EDX), and Fourier transform infrared (FTIR) analysis. The lattice parameters (a, b, and c) of the TiO2 sample were found to be a = b = 0.3778 nm, c = 0.9494 nm, and these values increased to a = b = 0.3779 nm, c = 0.9496 nm after the addition of Cu. The distance between the lattices of the TiO2 sample was measured at 0.3505 nm and increased to 0.3509 nm after Cu addition. The average crystallite size of the TiO2 sample was 33 nm, which increased to 43 nm after Cu impregnation. The strain value decreased from 2.76×10^(-3) to 1.82×10^(-3) after Cu addition. SEM results revealed that the morphology of the particles from the Cu-doped synthesis showed agglomeration. The success of Cu doping was confirmed by EDX mapping, which showed the presence of Ti, O, and Cu evenly distributed on the TiO2 surface. The FTIR spectrum indicated that TiO2 (P-25) and Cu-TiO2 particles had absorption peaks at similar wave numbers. However, in the absorption area of 1000 cm^-1 to 1250 cm^-1, new absorption bands affiliated with Cu-O bonds appeared in the Cu-TiO2 sample, resulting from TiO2 vibrations after Cu addition.
Innovating Physics Education with the Archio Application to Enhance Interest in Learning Archimedes' Law
Authors: Saqila Maya Shinta , Pramudita Finna , Hakim Marsa Raihanida , Saputra Riski Yulianto , Hudaa Syihaabul , Suryadi Ahmad
Published: July 2024

The main problem in physics education among students is the lack of interest in learning due to monotonous teaching methods such as lectures. Lectures are often considered uninteresting and ineffective. This research aims to assess the effectiveness of a Thunkable-based application named Archio in increasing learning interest. The study uses the 4-D development model (Define, Design, Develop, Disseminate) and was conducted at the end of 2023. The Define stage involved a survey to identify students' learning difficulties, which showed Archimedes' Law as the most difficult material. The Archio application was then designed (Design) and developed (Develop) with features such as learning materials, interactive simulations, quizzes, and reflections. At the Disseminate stage, the application was introduced through posters. The application received scores of 4.30 and 4.20 from expert and student validation results. The validation results indicated that the application is suitable for use with a very good category. The recommendation from this research is further development of the Archio application based on validator feedback to ensure its wider and smoother usage
The criminal in the prison-house of language: Conceptual writing to re-present Havelock Ellis’ use of “the criminal” in his book, The Criminal
Authors: Borchard Kurt
Published: July 2024

Criminology has historically promoted positivism, a disciplinary orientation producing reward structures for some researchers committed to deductive work rooted in developing concepts, hypothesizing relationships, and empirical testing. Its is useful, then, to review where such tendencies were initially conceived and promoted. Havelock Ellis’ 1890 book The Criminal, a then-seminal review of literature in criminal anthropology, concerns many topics involving criminals and criminality. In the following conceptual writing, I present here, verbatim, all instances where Ellis uses the exact phrase “the criminal” in his book, along with any words following the phrase in the sentence. The resulting text then deconstructs and re-imagines the true object of Ellis’ work: the creation of the supposed object of his study as self-evidently Real, existing outside of linguistic and discursive parameters. Ellis as detective (searching for the criminal everywhere but right under his writing nose) could never fully apprehend his ever-escaping subject. Yet, through discourse, Ellis and his fellow criminal anthropologists laid claim as those best qualified for establishing the criminal’s essential identity, an ideal type still pursued through government funded criminological research.
The Glance: Kinaesthetics, Emergence and Power
Authors: Shields Rob
Published: July 2024

Why differentiate “glancing” from “gazing”? This translation and rendition of a text that has appeared only in Portuguese considers the distinctiveness of the glance in the Western tradition of visualicity, power, knowledge and gender. While the glance has been acknowledged in visual studies and phenomenology, twenty years on from the original publication there are few sustained attempts to consider its role in the repertoire of visualicity or the ways that the glance is an example of aesthesis: it connects kinaesthetic experience to knowing and to sociality or relationality. Foucault, Hegel, Nietzsche and Kierkegaard cite the glance as a flash (de Koonig) of power-knowledge and its exercise, generally as an attribute of masculinity (Hegel) or authority (Foucault). The glance is liminal foresight into the coming moment as a scan of the visual present as well as an anticipatory search. It expresses desire and is attracted by visual stimulii, knotting affect to visual physiology. The glance is additionally tactical, anxious and furtive, an exercise in counterpower that seeks to “rotate the world on its axis” (Buber) in a way that repositions subjects and objects of the glance in a relation.
Assessing fecal metaproteomics workflow and small protein recovery using DDA and DIA PASEF mass spectrometry
Authors: Wang Angela , Fekete Emily E F , Creskey Marybeth , Cheng Kai , Ning Zhibin , Pfeifle Annabelle , Li Xuguang , Figeys Daniel , Zhang Xu
Published: July 2024

Aim: This study aims to evaluate the impact of experimental workflow on fecal metaproteomic observations, including the recovery of small and antimicrobial proteins often overlooked in metaproteomic studies. The overarching goal is to provide guidance for optimized metaproteomic experimental design, considering the emerging significance of the gut microbiome in human health, disease, and therapeutic interventions.

Methods: Mouse feces were utilized as the experimental model. Fecal sample pre-processing methods (differential centrifugation and non-differential centrifugation), protein digestion techniques (in-solution and filter-aided), data acquisition modes (data-dependent and data-independent, or DDA and DIA) when combined with parallel accumulation-serial fragmentation (PASEF), and different bioinformatic workflows were assessed.

Results: We showed that, in DIA-PASEF metaproteomics, the library-free search using protein sequence database generated from DDA-PASEF data achieved better identifications than using the generated spectral library. Compared to DDA, DIA-PASEF identified more microbial peptides, quantified more proteins with fewer missing values, and recovered more small antimicrobial proteins. We did not observe any obvious impacts of protein digestion methods on both taxonomic and functional profiles. However, differential centrifugation decreased the recovery of small and antimicrobial proteins, biased the taxonomic observation with a marked overestimation of Muribaculum species, and altered the measured functional compositions of metaproteome.

Conclusion: This study underscores the critical impact of experimental choices on metaproteomic outcomes and sheds light on the potential biases introduced at different stages of the workflow. The comprehensive methodological comparisons serve as a valuable guide for researchers aiming to enhance the accuracy and completeness of metaproteomic analyses.
MODEL OF RANDOM-LIKE PLANAR TRAJECTORIES WITH INTERSECTIONS
Authors: Romanuke Vadim , Pabich Michał
Published: July 2024

Background. Recently the task of detecting and identifying trajectories of objects whose genuine purposes are uncertain or strike threatening has become extremely important. The known approaches produce insufficiently smooth trajectories.
Objective. The purpose of the paper is to build a model of generating random-like planar trajectories, which would have sufficiently smooth curves. A trajectory may have self-intersections and may intersect other trajectories.
Methods. Preliminarily two starting points on a plane are generated. The distance and angle between these points are calculated, which then are successively updated to calculate new trajectory points using the polar coordinate system. A trajectory of  points is generated using  values of normally distributed random variables with zero mean and unit variance and four values of -uniformly distributed random variables.
Results. The random-like trajectory generator has the same time complexity as its predecessors, including the direction randomization generator and its modifications. Exemplary trajectories appear very realistic. Self-intersections are important to manoeuvre and confuse the opponent side. The trajectory has four parameters to adjust its heading, scattering of points, and intensity of turns and twists. These parameters serve as magnitudes to amplify the respective properties. The highest influence has the angle-scattering parameter. Four simple conditions can be embedded to fit the trajectory within a rectangular domain.
Conclusions. The suggested model should serve either for generating trajectory datasets to train manoeuvring-object detectors on them or for masking reconnaissance. The model allows balancing the trajectory smoothness and randomness.
A Batalha no Congresso Nacional: rastreando o papel dos militares na construção da Lei Antiterrorismo
Authors: France Guilherme de Jesus , Aranega André Duffles Teixeira
Published: July 2024

O artigo busca esclarecer qual foi o papel dos militares no processo legislativo que gerou Lei Antiterrorismo. Primeiro, discutimos brevemente os Estudos de Terrorismo. Segundo, sintetizamos as origens, especificidades e lacunas da primeira legislação brasileira a tratar extensivamente de terrorismo. Por fim, fornecemos uma perspectiva inédita sobre o papel do Ministério da Defesa e das Forças Armadas naquele processo legislativo ao analisar suas prioridades legislativas e interações com outros atores.
A efetividade do Regime Internacional de Mudança do Clima em relação ao Protocolo de Quioto e ao Acordo de Paris
Authors: Neves Aurélia
Published: July 2024

O descompasso entre compromissos firmados pelos atores internacionais e a persistência de comportamentos que descumprem aquilo acordado é um fenômeno comum nas relações internacionais. O presente artigo tem a proposta de investigar esse problema estudando o caso do Regime Internacional de Mudança do Clima e sua efetividade. Analisando e comparando o Protocolo de Quioto e o Acordo de Paris, com base na literatura especializada, algumas hipóteses explicativas são apresentadas.
Oral Microbiome: A Comprehensive Review of its Impact on Oral and Systemic Health
Authors: Rajasekaran John J. , Krishnamurthy Hari Krishnan , Bosco Jophi , Jayaraman Vasanth , Krishna Karthik , Wang Tianhao , Bei Kang
Published: July 2024

Purpose of review: This review investigates the oral microbiome's composition, functions, influencing factors, connections to oral and systemic diseases, and personalised oral care strategies. Recent findings: The oral microbiome is a complex ecosystem consisting of bacteria, fungi, archaea, and viruses that contribute to oral health. Various factors, such as diet, smoking, alcohol consumption, lifestyle choices, and medical conditions, can affect the balance of the oral microbiome and lead to dysbiosis, which can result in oral health issues like dental caries, gingivitis, periodontitis, oral candidiasis, and halitosis. Importantly, our review explores novel associations between the oral microbiome and systemic diseases including gastrointestinal, cardiovascular, endocrinal, neurological conditions, autoimmune diseases, and cancer. We comprehensively review the efficacy of interventions like dental probiotics, xylitol, oral rinses, fluoride, essential oils, oil pulling, and peptides in promoting oral health by modulating the oral microbiome. Summary: This review emphasizes the critical functions of the oral microbiota in dental and overall health, providing insights into the effects of microbial imbalances on various diseases. It underlines the significant connection between the oral microbiota and general health. Furthermore, it explores the advantages of probiotics and other dental care ingredients in promoting oral health and addressing common oral issues, offering a comprehensive strategy for personalized oral care.
The Content and Nature of Rumination in Chinese Young and Middle-Aged Patients with Acute Coronary Syndrome: A Qualitative Study
Authors: Li Anan , Nie Yangfan , Chi Meixuan , Wang Naijuan , Ji Siying , Zhu Zhaoying , Li Shan , Hou Yunying
Published: July 2024

Individuals have different rumination patterns after experiencing traumatic events in different cultural backgrounds and situations. This study was aimed to explore the experience of Chinese young and middle-aged patients with acute coronary syndrome (ACS) to understand the content and nature of their rumination. Fourteen participants were selected using the purposive sampling method in XXX hospital from May 2023 to December 2023. Data were collected using semi-structured interviews and analyzed using Colaizzi’ s 7-step phenomenological method. The content of rumination in young and middle-aged patients with ACS can be summarized into 2 categories: non-adaptive rumination and adaptive rumination. Non-adaptive rumination included 3 themes: worry or anxiety, scare, and depression. Adaptive rumination included 4 themes: tracing of disease processes, enhancement of disease cognition, improvement of health awareness, and adjustment of lifestyle cognition. In conclusion, although Chinese young and middle-aged patients with ACS experience negative emotions after a traumatic cardiac event, they gradually make positive changes, and optimism and information support play important roles in this transition, which provide a fundamental understanding of rumination experiences in Chinese young and middle-aged patients with ACS and provide new data for healthcare providers when designing intervention programs to enhance post-traumatic growth in these patients.
Aripiprazole, but Not Olanzapine, Alters the Response to Oxida-Tive Stress, Reducing the Activation of Mitogen-Activated Protein Kinases (MAPKs) and Promoting Cell Survival in FAO Cells
Authors: Kramar Barbara , Marolt Tinkara Pirc , Goler Ayse Mine Yilmaz , Šuput Dušan , Milisav Irina , Monsalve Maria
Published: July 2024

Chronic administration of atypical antipsychotics (AAPs) is commonly associated with in-creased cardiovascular disease load. Although the increase in weight gain and related dis-ease risk is generally considered the main contributing factor, direct interference with mi-tochondrial bioenergetics, particularly in the liver, where these drugs are catabolized, is emerging as an additional relevant contributor to metabolic disease risk that needs to be considered. In this study, we compared the effects of two AAPs with disparate metabolic profiles, olanzapine (OLA), which is obesogenic, and aripiprazole (ARI), which is not, on the response of Fao cells to oxidative stress. We found that Fao cells treated with ARI sur-vive better a challenge with H2O2 while OLA treatment has the opposite effect. This en-hanced survival is not related to a reduction in the apoptosis rate. In fact, ARI treated cells display higher apoptotic rates than control cells exposed to H2O2. Gene expression analysis of pro and anti-apoptotic factors revealed that the changes induced by H2O2 were generally dampened in ARI treated cells, but not in OLA treated cells, suggesting a reduced respon-siveness to stimuli, a notion that was consistent with a reduced activation of MAPK and STAT3 phosphorylation in response to H2O2, while OLA enhanced their activation in re-sponse to H2O2. Loss of stress response in ARI treated cells is consistent with the elevation of mitochondrial production of O2•-, a known desensitizing factor. The physiological rele-vance of the increased production of O2•- in ARI treated cells is further supported by the observed elevation of the mitophagy flux in ARI treated cells, likely related to mitochon-drial damage. An additional relevant finding was that OLA treatment protected the pro-teasome activity in Fao cells exposed to H2O2, an effect possibly related to the better preservation of stress signaling and mitochondrial function in OLA treated cells. In sum, this study highlights the underlying alterations in cell physiology derived from the inter-ference of ARI with mitochondrial function, that de-sensitize cells to stress signaling, while OLA has the opposite effect.
Conserved Antagonization of Type I Interferon Signaling by Arterivirus GP5 Proteins
Authors: Ringo Rissar Siringo , Choonnasard Amonrat , Okabayashi Tamaki , Saito Akatsuki
Published: July 2024

Arterivirus can establish persistent infection in animals such as equids, pigs, nonhuman primates, rodents, and possums. Some Arterivirus can even cause overt and severe diseases such as Equine Arteritis in horses and Porcine Reproductive and Respiratory Syndrome in pigs, leading to huge economic losses. Arterivirus have evolved viral proteins to antagonize the host cell’s innate immune responses by inhibiting type I interferon (IFN) signaling, assisting viral evasion and persistent infection. So far, the role of the Arterivirus glycoprotein 5 (GP5) protein in IFN signaling inhibition remains unclear. Here, we investigated the inhibitory activity of 47 Arterivirus GP5 proteins derived from various hosts. We demonstrated that all GP5 proteins showed conserved activity for antagonizing TIR-domain-containing adapter protein inducing interferon-β (TRIF)-mediated IFN- signaling through TRIF degradation. In addition, Arterivirus GP5 proteins showed conserved inhibitory activity against IFN-β signaling, induced by either pig or human TRIF. Furthermore, certain Arterivirus GP5 proteins could inhibit the induction of IFN-stimulated genes. These findings highlight the role of Arterivirus GP5 proteins in supporting persistent infection.
Enhancement of orthodontic tooth movement by local administration of biofunctional molecules: a comprehensive systematic review
Authors: Ciobotaru Cristina Dora , Feștilă Dana , Dinte Elena , Muntean Alexandrina , Boșca Bianca Adina , Ionel Anca , Ilea Aranka
Published: July 2024

Enhancement of orthodontic tooth movement (OTM) through local administration of biofunctional molecules has become increasingly significant, particularly for adult patients seeking aesthetic and functional improvements. This comprehensive systematic review analyzes the efficacy of various biofunctional molecules in modulating OTM, focusing on the method of administration and its feasibility, especially considering the potential for topical application. A search across multiple databases yielded 36 original articles of experimental human and animal OTM models, which examined biofunctional molecules capable of interfering with the biochemical reactions that cause tooth movement during orthodontic therapy, accelerating the OTM rate through their influence on the bone metabolism (Calcitriol, Prostaglandins, Recombinant human Relaxin, RANKL and RANKL expression plasmid, growth factors, PTH, osteocalcin, vitamin C and E, biocompatible reduced graphene oxide, exogenous thyroxine, sclerostin protein, a specific EP4 agonist (ONO-AE1-329), carrageenan and herbal extracts). The results indicated a variable efficacy in accelerating OTM, with Calcitriol, Prostaglandins (PGE1 and PGE2), RANKL, growth factors and PTH, among others, showing promising outcomes. PGE1, PGE2 and Calcitriol experiments had statistically significant outcomes in both human and animal studies, and, while other molecules underwent only animal testing, they could be validated in the future for human use. Notably, only one of the animal studies explored topical administration, which also suggests a future research direction. This review concluded that while certain biofunctional molecules demonstrated potential for OTM enhancement, the evidence is not definitive. The development of suitable topical formulations for human use could offer a patient-friendly alternative to injections, emphasizing comfort and cost-effectiveness. Future research should focus on overcoming current methodological limitations and advancing translational research to confirm these biomolecules' efficacy and safety in clinical orthodontic practice.
Iodophor/H2O2 Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase
Authors: Liu Yashuai , Yuan Yutong , He Jing , Han Sheng , Liu Yan
Published: July 2024

A convenient and efficient strategy for the preparation of 2-sulfonylindoles has been achieved through iodophor/H2O2-mediated 2-sulfonylation of indoles with readily available sulfonyl hydrazides in aqueous phase. Iodophor is commercially available and serves as the green catalyst and aqueous phase. A series of 2-sulfonylated products from indoles and N-methylpyrrole were synthesized in moderate yields in only 10 min. Control experiments were also conducted to reveal the mechanism. This method is environment friendly, easy to operate and suitable for a wide range of substrates.
The Burden of Inpatient Hospitalizations with Cardiac and Cerebrovascular Diseases in Patients with Type 1 Diabetes: Insights from the National Inpatient Sample in the US
Authors: Kwok Chun Shing , Qureshi Adnan I. , Phillips Anne , Lip Gregory Y.H. , Hanif Wasim , Borovac Josip A.
Published: July 2024

Background: This study aimed to evaluate the burden and impact of cardiac and cerebrovascular disease (CCD) on hospital inpatients with type 1 diabetes mellitus (T1DM). Methods: This is a retrospective nationwide cohort study of people with T1DM with or without CCD in the US National Inpatient Sample between 2016 to 2019. The in-hospital mortality rates, length of stay (LoS) and healthcare costs were determined. Results: A total of 59,860 T1DM patients had a primary diagnosis of CCD and 1,382,934 did not. The median LoS was longer for patients with CCD compared to no CCD (4.6 vs. 3 days). Patients with T1DM and CCD had greater in-hospital mortality compared to those without CCD (4.1% vs. 1.1%, p<0.001). The estimated total care cost for all patients with T1DM with CCD was approximately US $326 million. The adjusted odds of mortality compared to patients with non-CCD admission was greatest for intracranial hemorrhage (OR 17.37, 95%CI 12.68-23.79), pulmonary embolism (OR 4.39, 95%CI 2.70-7.13), endocarditis (OR 3.46, 95%CI 1.22-9.84), acute myocardial infarction (OR 2.31, 95%CI 1.92-2.77) and stroke (OR 1.47, 95%CI 1.04-2.09). Conclusions: The burden of CCD in patients with T1DM is substantial and significantly associated with increased hospital mortality and high healthcare expenditures.
Mapping the Influence of Light Intensity on the Transgenerational Genetic Architecture of Arabidopsis thaliana
Authors: Mei Jie , Che Jincan , Shi Yunzhu , Fang Yudian , Wu Rongling , Zhu Xuli
Published: July 2024

Light is a crucial environmental factor that influences the phenotypic development of plants. Despite extensive studies on the physiological, biochemical, and molecular mechanisms of the impact of light on phenotypes, genetic investigations regarding light-induced transgenerational plasticity in Arabidopsis thaliana remain incomplete. In this study, we used Arabidopsis thaliana as the material, then gathered phenotypic data regarding leaf number and plant height under high- and low-light conditions from two generations. In addition to the developed genotype data, a functional mapping model was used to locate a series of significant SNPs. Under low-light conditions, a noticeable adaptive change in the phenotype of leaf number in the second generation suggests the presence of transgenerational genetic effects in Arabidopsis thaliana under environmental stress. Under different lighting treatments, 33 and 13 significant genes associated with transgenerational inheritance were identified, respectively. These genes are largely involved in signal transduction, technical hormone pathways, light responses, and the regulation of organ development. Notably, genes identified under high-light conditions more significantly influence plant development, whereas those identified under low-light conditions focus more on responding to external environmental stimuli.
Normal Values for the fT3/fT4 Ratio: Centile Charts (0-29 Years) and Their Application for the Differential Diagnosis of Children with Developmental Delay
Authors: Wilpert Nina-Maria , Thamm Roma , Thamm Michael , Kratzsch Jürgen , Seelow Dominik , Vogel Mandy , Krude Heiko , Schuelke Markus
Published: July 2024

Primary congenital hypothyroidism is readily diagnosed based on elevated plasma TSH levels. In contrast, in the rare disorders of thyroid hormone resistance, TSH and often also thyroid hormone levels are within the normal range. Thyroid hormone resistance is caused by defects in hormone metabolism, transport, or receptor activation and has the same severe consequences for childhood development as congenital hypothyroidism. A total of 23,522 data points from a large cohort of children and young adults were used to generate normal values and sex-specific percentiles for the ratio of free T3 to free T4 (fT3/fT4 ratio). The aim was to determine whether cases with genetically confirmed thyroid hormone resistance (MCT8, THRα, and SECSIBP2 defects) had an abnormal fT3/fT4 ratio. Indeed, we were able to demonstrate a clear separation of patient values for the fT3/fT4 ratio from normal and pathological controls (e.g., children with severe cerebral palsy). We therefore recommend the use of the fT3/fT4 ratio as a readily available screening parameter in children with developmental delay for the identification of thyroid hormone resistance syndromes. The fT3/fT4 ratio can be plotted on centile charts using our free online tool at http://www.thyroid-hormone-ratio.org that accepts various SI and non-SI units.
Master Regulators of Causal Networks in Intestinal- and Diffuse-Type Gastric Cancer and the Relation to RNA Virus Infection Pathway
Authors: Tanabe Shihori , Quader Sabina , Cabral Horacio , Perkins Edward J , Yokozaki Hiroshi , Sasaki Hiroki
Published: July 2024

The causal networks are important for understanding the signaling alterations in diseases. To reveal the network pathways affected in epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs), which are related to poor prognosis of cancer, the molecular networks and gene expression in diffuse- and intestinal-type gastric cancer (GC) have been analyzed. The network pathways in GC were analyzed in Ingenuity Pathway Analysis (IPA). The analysis of the probe sets of which gene expression has significant differences between diffuse- and intestinal-type GC in RNA Sequencing publicly available data identified 1099 causal networks in diffuse- and intestinal-type GC. Master regulators of the causal networks included lenvatinib, pyrotinib, histone deacetylase 1 (HDAC1), mir-196, and erb-b2 receptor tyrosine kinase 2 (ERBB2). The analysis of the HDAC1-interacting network identified the involvement of regulation of EMT by growth factors pathway, coronavirus pathogenesis pathway, and vorinostat. The network had RNA-RNA interactions with microRNAs such as mir-10, mir-15, mir-17, mir-19, mir-21, mir-217, mir-223, mir-25, mir-27, and mir-34. These molecular networks revealed in the study may lead to the identification of drug targets for GC.
Utilizing Olive By-Products in the Diet of Bísaro Pigs: Enhancing the Value of the Breed's Dry-Cured Products
Authors: Leite Ana , Vasconcelos Lia , Lopez Sergio , Monteiro Divanildo Outor , Pinheiro Vitor , Rodrigues Sandra , Teixeira Alfredo
Published: July 2024

This study aimed to evaluate the influence of olive cake on the diet of autochthonous Bísaro pigs in processed products. To this purpose, loins and “cachaços” were used and subjected to a manufacturing flowchart to obtain a dry-cured product. Both products were subjected to the same formulation, ingredients, and curing steps. Regarding the physicochemical composition, there were significant differences between the two products for the parameters of aw (p<0.001), moisture (p<0.001), total fat (p<0.001), protein (p<0.001), and haem pigments (p<0.001). As for the diet, it only significantly influences the NaCl content (p<0.05). Neither the product nor the diet had any influence (p>0.05) on the fraction of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), and polyunsaturated fatty acids (PUFA). However, there is a significant difference when it comes to omega 3 (p<0.05). These fatty acids increased with the addition of olive cake, and the diet with olive cake centrifuged by 25% had the highest value for both products. The increase in this omega 3 resulted in a decrease in the PUFA n-6/n-3 ratio (p<0.01) in the diets with olive cake, compared to the control diets.
Correlating the Segmental-Relaxation Time of Polystyrene
Authors: Hieber C. A.
Published: July 2024

A previous related paper dealing with the density relaxation of polystyrene (PS) has shown that the equilibrium relaxation time (eq) has a purely exponential temperature dependence (ETD) below ≈ 100ºC. Such an ETD is now also confirmed based upon available dielectric-spectra data for PS. By combining the ETD behavior of eq (or aT) at low temperatures with a VFTH behavior at higher temperatures (based mainly on available recoverable-shear-compliance data), a composite correlation for eq (or aT) is developed which is continuous with continuous slope at a crossover temperature which is found to be 99.22ºC, where eq = 92.15 sec. This composite representation is shown to describe (without any adjustable parameters) available independent data for the segmental-relaxation time over a finite range both above and below Tcrossover (i.e. the glass-transition temperature).
Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction
Authors: Lambroia Luca , Dioguardi Carola Conca , Puccio Simone , Pansa Andrea , Alvisi Giorgia , Basso Gianluca , Cibella Javier , Colombo Federico S. , Marano Salvatore , Basato Silvia , Alfieri Rita , Giudici Simone , Castoro Carlo , Peano Clelia
Published: July 2024

Esophageal cancer is an extremely deadly tumor that accounts for 5% of all cancer deaths. The two main subtypes of the disease are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). To date, few studies analyse EAC for transcriptional signatures associated with diagnosis and/or prognosis, while most focus on the analysis of transcriptional profiles of ESCC. In this study, we used single-cell RNA sequencing (scRNA-seq) analysis of CD45+ cells enriched from Tumors and matched Non Tumor tissues from therapy naїve patients to identify all types of immune cells present in tumor immune infiltrate and its transcriptional profile. In addi-tion, we analysed the entire transcriptome in a cohort of 23 patients whose tissue biopsies were taken from Tumors and matched with Non Tumor tissue.
The transcriptional signatures we obtained were then used to stratify a large cohort of TCGA EAC patients, demonstrating a strong association with their prognosis, as well as the ability to predict a patient's clinical outcome and better define the prognosis of EAC after surgery. In addition, these features may lead patients to effective therapies including immunotherapy approaches.