bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury
Authors: Grigorieva Irina V. , Oszwald Andre , Grigorieva Elena F. , Schachner Helga , Neudert Barbara , Ostendorf Tammo , Floege Jürgen , Lindenmeyer Maja T. , Cohen Clemens D. , Panzer Ulf , Aigner Christof , Schmidt Alice , Grosveld Frank , Thakker Rajesh V. , Rees Andrew Jackson , Kain Renate
Published: August 2019

Significance Statement

Mesangial cells play a crucial role in maintaining glomerular homeostasis and injuries to these cells often result in progression to CKD like IgA and diabetic nephropathies. However, the transcription factors involved in mesangial cell development and function are largely unknown. The authors describe the role transcription factor GATA3 plays in mesangial cells in embryonic kidneys and healthy and injured adult glomeruli. Mice with haploinsufficiency of GATA3 have too few MC precursor cells and glomerular abnormalities. GATA3 expression increases in mesangial cells in mesangial proliferative GN in humans and rodent models suggesting GATA3 is important for glomerular homeostasis and response to injury. GATA3 also may be a useful a nuclear marker of human mesangial cells.

Background

GATA3 is a dual-zinc finger transcription factor that regulates gene expression in many developing tissues. In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to develop kidneys. In humans, autosomal dominant GATA3 mutations can cause renal aplasia as part of the hypoparathyroidism, renal dysplasia, deafness (HDR) syndrome that includes mesangioproliferative GN. This suggests that GATA3 may have a previously unrecognized role in glomerular development or injury.

Methods

To determine GATA3’s role in glomerular development or injury, we assessed GATA3 expression in developing and mature kidneys from Gata3 heterozygous (+/−) knockout mice, as well as injured human and rodent kidneys.

Results

We show that GATA3 is expressed by FOXD1 lineage stromal progenitor cells, and a subset of these cells mature into mesangial cells (MCs) that continue to express GATA3 in adult kidneys. In mice, we uncover that GATA3 is essential for normal glomerular development, and mice with haploinsufficiency of Gata3 have too few MC precursors and glomerular abnormalities. Expression of GATA3 is maintained in MCs of adult kidneys and is markedly increased in rodent models of mesangioproliferative GN and in IgA nephropathy, suggesting that GATA3 plays a critical role in the maintenance of glomerular homeostasis.

Conclusions

These results provide new insights on the role GATA3 plays in MC development and response to injury. It also shows that GATA3 may be a novel and robust nuclear marker for identifying MCs in tissue sections.
„Lehrstück” a politikai-esztétikai neveléshez – Brecht/Eisler: Az intézkedés (Die Maßnahme)
Authors: Asztalos Bence
Published: August 2019

Bertolt Brecht’s learning-plays (“Lehrstück”), created between 1929 and 1935 were – in the words of the author – „pedagogical experimentation with theatrical elements but without requiring actual theatres” (Brecht, 1993, p. 167). According to him, the name learning-play indicates that the instructive piece is instructive for the performer; therefore, it needs no audience (Brecht, 1978). The writer considered the process of learning to be important rather than the end-product, that is, the performance. Investigating the realization of Brecht’s pedagogical, esthetical and medial vision, this study contributes to judging these pedagogical pieces as parts, not only of theatrical history but, also, pedagogy.
Tail Flick v1
Authors: Feldman Eva
Published: August 2019

Summary: The Tail Flick assay is a pain receptive assay in which a mouse is placed within a restraining tube with its tail protruding. The tail is placed on a level surface, a radiant heat is applied to the tail and the latency of the mouse to remove its tail from the heat is recorded. This latency is used as a measure to indicate neurological pathology. Diabetic Complication:
Determination of Glomerular Filtration Rate in Conscious Mice using FITC-inulin v1
Authors: Qi Zhonghua , D. Breyer Matthew
Published: August 2019

Summary: This protocol describes the procedures for estimating glomerular filtration rate in conscious mice based on Fluorescein Isothiocyanate-inulin (FITC-inulin) clearance following a single bolus intravenous injection. Diabetic Complication: Reference: 1. Hem, A., Smith, A.J., and Solberg, P. 1998. Saphenous vein puncture for blood sampling of the mouse, rat, hamster, gerbil, guinea pig, ferret and mink. Lab Anim 32:364-368. 2. Sturgeon, C., Sam, A.D., 2nd, and Law, W.R. 1998. Rapid determination of glomerular filtration rate by single-bolus inulin: a comparison of estimation analyses. J Appl Physiol 84:2154-2162. 3. Qi, Z., Whitt, I., Mehta, A., Jin, J., Zhao, M., Harris, R.C., Fogo, A.B., and Breyer, M.D. 2003. Serial Determination of Glomerular Filtration Rate in Conscious Mice Using FITC-Inulin Clearance. Am J Physiol Renal Physiol.
Glucose "Clamp" for measurement of whole body insulin-stimulated glucose disposal v1
Authors: McClain Donald
Published: August 2019

Summary: This is the standard protocol for measuring insulin action in terms of total body glucose disposal. It is the "gold standard" for quantifying insulin resistance/sensitivity. Diabetic Complications:
Measurement of Left Ventricular Performance in Langendorff Perfused Mouse Hearts v1
Authors: Dale Abel E.
Published: August 2019

Summary: This protocol describes the procedure used by the DiaComp for measuring left ventricular performance in isolated retrogradely perfused mouse hearts. Diabetic Complication:
Nerve Conduction Velocity Tests v1
Authors: Feldman Eva
Published: August 2019

Summary: To confirm the presence of diabetic neuropathy, nerve conduction velocity (NCV) studies are performed. The animals are anesthetized with 30/2.5 mg/kg ketamine/xylazine to prevent discomfort. Body temperature is monitered with a dermal temperature probe and maintained at 32º C with a warming lamp during NCV. Body temperature is maintained at 37ºC after NCV using a warming pad to ease animal stress from anesthetic. The nerve studies last less than 30 min per rat or mouse. The electrodes are cleaned with 70% alcohol between animals to maintain pathogen-free status. Diabetic Complication:
Manual Cell Counting v1
Authors: Kumar Aparna , Al-Azzeh Dana , Lab Schuele
Published: August 2019

Manual counting of cells using a Hemocytometer.
VARIAÇÃO ESPACIAL E TEMPORAL DA BIODISPONIBILIDADE DE METAIS NA REGIÃO ESTUARINA DO COMPLEXO ESTUARINO-LAGUNAR DE IGUAPE-CANANÉIA, SUDESTE DO BRASIL
Authors: Azevedo Julio Cesar Rodrigues , Salgado Lilian Dalago
Published: August 2019

O Complexo Estuarino-Lagunar de Iguape-Cananéia (CELIC) apresenta condições ambientais distintas entre suas porções Norte e Sul e sofre com diferentes pressões antrópicas. Este estudo avaliou a variação espacial e temporal da biodisponibilidade dos metais Fe, Zn, Mn, Co, Cu, Cr, Cd, Pb and Ni, nos sedimentos em 8 pontos do CELIC em 2 períodos de 2013. A avaliação da biodisponibilidade dos metais deu-se através do método da extração simultânea de íons metálicos e sulfetos volatizados por acidificação (SEM/SVA). Foi vista ampla variabilidade espacial e temporal nos parâmetros analisados, onde a média dos metais fortemente biodisponíveis deu-se na ordem de Fe>Mn>Zn>Pb>Cu. Todos os pontos apresentaram razão SEM/SVA > 1 para os íons metálicos Pb, Cd, Ni, Cu e Zn, com maior toxicidade dos sedimentos a Norte, sugerindo a biodisponibilidade desses metais e destacando o potencial destes sedimentos de causar efeitos adversos à biota local. Estes resultados salientam as influências do aporte de resíduos urbanos, agrícolas e de atividades mineradoras pretéritas ao sistema, advindos especialmente do Rio Ribeira de Iguape.
ECONOMIC AND PRODUCTIVE PERFORMANCE OF EARTH WORMS Eudrilus eugeniae ON DIFFERENT DIETARY SOURCES
Authors: Lopes Fábio Silva do Carmo , Ferreira Elvino , Porto Marlos Oliveira , Pontuschka Rute Bianchini , Sales Maykel Franklin Lima , Cavali Jucilene
Published: August 2019

Eudrilus eugeniae is a foreign species that is well adapted to captivity system adopted in Brazil. The objective was evaluate the productive and economic performance of earthworms in different substrates in two 100 days. In aim 1, the control substrate composed by cattle manure and forage grass (CMG) was supplemented with minerals (MM), soybean meal (SB) and ground corn (GC). The substrate containing GC was higher than in average weight (AW) of 127% and average weight gain (AWG) of 332% when compared to CMG substrate, superior in 193% AW and 252% AWG when compared to MM and 251% AW and 403% AWG when compared to the substrate with SB. In aim 2, were used different amounts of GC in substrate. The production of the substrate that contained 5% GC was superior in 9%, 12% and 20% with regard to those that had a composition of 10%, 15% and 20% of GC, respectively. As for the difference between the costs and the benefits of each of the substrates, the 5% GC substrate showed a positive return of BRL$ 35.32 for each BRL$1.00 invested and an economic performance that was 205% superior to MM, the second best option among substrates. 5% GC performed better and more efficient and economically viable production of worms.
EXTRAÇÃO E EXPORTAÇÃO DE MACRONUTRIENTES EM LAVOURAS DE MILHO DE ALTA PRODUTIVIDADE
Authors: Oliveira Thaísa Fernanda , Oliveira Victor Jordão Braga , Clemente Junia Maria , Aquino Leonardo Angelo de , Reis Marcelo Rodrigues dos , Fernandes Flavio Lemes
Published: August 2019

O conhecimento da variabilidade da nutrição de plantas e da produtividade em áreas cultivadas com plantas de milho que apresentam alta produtividade pode fornecer importantes subsídios na racionalização do uso de insumos e auxiliar no manejo da fertilidade do solo. Essa pesquisa tem como objetivo determinar os padrões de extração e de exportação de nitrogênio (N), fósforo (P), potássio (K), cálcio (Ca), magnésio (Mg) e enxofre (S) por lavouras de milho de alta produtividade. Quinze talhões de milho cultivados sob sistema convencional e que apresentavam alto potencial produtivo foram amostrados no ano agrícola 2014/2015 na região do Alto Paranaíba (MG) e avaliaram-se a produtividade e a extração e exportação de N, P, K, Ca, Mg e S. Os acúmulos de N, P, K e S em grãos e extração total tiveram efeitos positivos na produtividade da cultura do milho. A massa de mil grãos foi o componente de produtividade mais importante na definição da produtividade. A extração e exportação de N, P, K e S aumentaram linearmente com o aumento da produtividade. Os resultados fornecem dados importantes sobre a absorção e partição de nutrientes dos híbridos atuais e permitem aprimorar as recomendações de adubação para produção de grãos de milho.
GESTÃO ORGANIZACIONAL EM APOIO À TOMADA DE DECISÃO: UMA ANÁLISE ATRAVÉS DAS PERSPECTIVAS ESTRATÉGICAS NA AMBIÊNCIA COOPERATIVISTA
Authors: Ramos Josefa Edileide Santos , Borba Marcelo da Costa , Alves Maria do Carmo Maracajá , Barros Jose Eduardo Melo , Rego Andrea de Fátima de Oliveira , Monte Helio Beretta Dal
Published: August 2019

O presente artigo toma por pressuposto que as decisões tomadas por uma cooperativa agrícola são complexas e envolvem múltiplos objetivos. Sendo assim, este artigo teve como objetivo analisar o processo de gestão organizacional, como ferramenta de apoio à tomada de decisão, de uma cooperativa agrícola na microrregião do Brejo paraibano. Quanto aos procedimentos metodológicos, esta pesquisa apresenta abordagem qualitativa através do estudo de caso com coleta de dados primários, entrevistas semiestruturadas e análise documental. Na análise foram consideradas as quatro dimensões do Balanced Scorecard além da avaliação geral da ferramenta. Os resultados mostraram que o mapeamento das ações pode ajudar no compartilhamento do conhecimento com os colaboradores e almejar ganhos mútuos com vantagens na economia de escala e na comercialização do produto final. O êxito dessa organização passa por um processo longo de monitoramento das ações, visando planejamento e controle estratégico organizacional. O estudo propôs um modelo de mapa estratégico, assim como faz uma proposta de projeção para os próximos quatro anos. A pesquisa fornece ainda um conjunto de indicadores estratégicos que podem ser de grande importância na tomada de decisão e de construção de um instrumento capaz de contribuir estrategicamente com o desempenho da cooperativa.
MERCADO BRASILEIRO DE FRANGO HALAL: INFLUÊNCIAS DO AMBIENTE INSTITUCIONAL E BARREIRAS À ENTRADA
Authors: Silva Pedro Xavier da , Artuzo Felipe Dalzzotto , Canozzi Maria Eugênia
Published: August 2019

O mercado de carne de frango Halal, destinado principalmente à população muçulmana, atualmente representa mais de 35% da carne de frango exportada no país. O padrão de produção Halal possui diversas peculiaridades que acabam por modular a competitividade do mercado. Competitividade essa que possui inúmeras formas de interpretação e parâmetros para mensuração, dependendo da abordagem teórica. O estudo que segue se propõe a analisar as características do Ambiente Institucional que delimita este mercado específico, e, a partir daí, identificar as principais barreiras à entrada para novas empresas. Essas barreiras são características da estrutura de determinado mercado que resguardam as empresas consolidadas, devido à imposição de custos às empresas entrantes potenciais. Essas características foram evidenciadas em instituições informais (aspectos culturais e religiosos) e formais (legislação).
IDENTIFICAÇÃO DE IMPACTOS AMBIENTAIS NAS ÁGUAS DO TRECHO PERENIZADO DO RIO PIANCÓ
Authors: Ismael Fernanda Carolina Monteiro , Leite José Cleidimário Araújo , Ismael Daniele Aparecida Monteiro , Silva Elton Ferreira da , Freitas Graziela Pinto de , Sousa Thâmara Martins Ismael de
Published: August 2019

Neste trabalho teve-se por objetivo identificar os impactos ambientais nas águas do trecho perenizado do rio Piancó. Para tanto, um diagnóstico ambiental simplificado da área foi realizado, por meio de pesquisas bibliográficas, visitas de campo, geoprocessamento, fotodocumentação e consultas a órgãos públicos, a partir do qual foram identificadas as atividades antrópicas com potencial impactante das águas do rio. Foram identificados os impactos por meio dos métodos Ad Hoc, Check Lists e Matriz de Interação. De acordo com os resultados, obtiveram-se 12 tipos de atividades antrópicas de alto potencial impactante, com predominância da agricultura, em 27,9% do total. Identificaram-se 132 impactos ambientais nas águas do rio. A atividade antrópica “responsável” pelo maior número de impactos ambientais significativos foi a urbanização. Por fim, espera-se que este estudo sirva como subsídio para o planejamento e implantação de políticas públicas voltadas à gestão hídrica e à sustentabilidade ambiental da região, e ainda venha a contribuir para o acervo bibliográfico técnico e científico sobre o tema, bastante carente na literatura, em especial para a área de estudo.
Estrategias en internet a partir de un modelo de dinámica competitiva
Authors: García Villalobos Juan Carlos , Mateos de Cabo Ruth , López Fernández Luis , Fernández Sanjuán Miguel Ángel
Published: August 2019

En el presente trabajo se estudia un modelo que describe las principales características del mercado de Internet y las dinámicas competitivas de los denominados sitios web. Este modelo, basado en las ecuaciones de Lotka-Volterra, analiza situaciones del tipo ‘el ganador se lleva todo’ manifestadas recurrentemente en mercados altamente competitivos. Con base en su tratamiento tanto cuantitativo como cualitativo se ofrecen una serie de recomendaciones estratégicas para mejorar resultados, por supuesto, coherentes con las tendencias observadas en la realidad de la Red. Dentro de estas recomendaciones destaca la estrategia de competición, que se propone como una opción viable para que los sitios pequeños puedan hacer frente a los grandes líderes de Internet; reforzada por su fundamento en consonancia con las predicciones propias de un modelo de dinámica competitiva. Junto a ello, también se formulan diversas estrategias para los sitios de nueva creación o recién llegados al mercado (los conocidos start-ups) como la de segmentación y los programas de filiación entre portales verticales.
El Santo Grial de la comunicación: en busca de las claves y dinámicas de la formación de un pensamiento estratégico en las escuelas de comunicación en América Latina
Authors: Roveda Hoyos Antonio
Published: August 2019

Se podría afirmar que el pasado, presente y futuro de la formación profesional en Comunicación y Periodismo en América Latina es tan reciente y complejo, a la vez, como difuso y angustiado. En los procesos de formación en esta disciplina prima más (algunas veces) la improvisación curricular, el desconocimiento del contexto (laboral político, económico, social e inclusive tecnológico de la profesión y las ciencias), el olvido por la investigación pertinente y, obviamente, el impacto de los profesionales y del campo disciplinar en la sociedad. La “formación en pensamiento estratégico” no es hoy una prioridad en la construcción de las mallas curriculares de la universidad. Hecho que, sin duda, continúa perseverando de manera atávica la distancia entre la formación en la academia y las necesidades del contexto. Si la academia persiste en desconocer el contexto laboral, social, político, económico, etc.; y, a su vez, el contexto, la empresa, la industria, los medios y los escenarios laborales no cuentan con la academia, estamos entonces formando sin pertinencia (y en el olvido) y con un bajísimo nivel de impacto, de coherencia y de servicio al cambio y al desarrollo social de nuestro pueblos.
Responsabilidad social y diversidad de la comunidad
Authors: Brenes Alvarado María del Rocío
Published: August 2019

En la era de la globalización de los mercados, el rol de las empresas evolucionó hacia una visión integral basada en la construcción de valor para sus distintos grupos de interés o stakeholders, sin cuyo apoyo la organización dejaría de existir. Esta nueva manera de “ser” se conoce como Responsabilidad Social Empresarial o corporativa. Con el presente trabajo se pretende lograr el objetivo de conocer el estado de desarrollo de la RSE en el mundo, en Latinoamérica y específicamente en Costa Rica.
El turismo 2.0. Un nuevo modelo de promoción turística
Authors: Sánchez Amboage Eva
Published: August 2019

Como consecuencia del empleo masivo de Internet el perfil del cliente ha cambiando, llegando a convertirse en lo que los entendidos llaman “Adprosumer”. Se unen en este término distintos conceptos: AD (anuncio), PRO (productor), SUMER (consumidor). Es esta una forma de resumir al nuevo cliente de la Web 2.0, el que recomienda, participa de la promoción y consume un producto. Ante este nuevo vocablo y nuestro interés por el sector turístico nos hacemos las siguientes cuestiones ¿Están las empresas turísticas adaptándose a este nuevo cliente? ¿Han cambiado su forma de promocionar los servicios turísticos? ¿Cómo influye el 2.0 en el sector turístico?A lo largo del presente artículo intentaremos contestar a estas interrogaciones a través del análisis del Turismo 2.0.
Análisis de la comunicación en la promoción del Camino de Santiago como producto turístico
Authors: Mondelo López Silvia , Rodríguez Fernández Magadalena
Published: August 2019

El Camino de Santiago se ha ido consolidando con el paso de los años en uno de los atractivos turísticos más importantes de Galicia. Prueba de ello es que gran parte de los visitantes de la Comunidad Autónoma han llegado directa o indirectamente a través de esta ruta de peregrinación milenaria. Precisamente, uno de los aspectos clave a la hora de dar a conocer el Camino tanto a nivel nacional como internacional han sido las diversas campañas de comunicación y promoción desarrolladas al respecto. Es por ello que el objetivo central de este artículo se fundamenta en analizar la promoción llevada a cabo en torno al Camino de Santiago como producto turístico4, tomando como especial referencia las acciones desarrolladas durante el pasado Año Santo o Xacobeo 2010. Para la realización de esta investigación, la metodología utilizada se ha basado en el empleo de fuentes primarias. Las cuales se han fundamentado en la elaboración y realización de entrevistas en profundidad a un grupo de personas vinculadas, de una manera u otra, con el Camino de Santiago y su comunicación
El procesamiento de la información de las personas mayores y su actitud hacia el anuncio
Authors: Estrada M. , Sánchez J. , Fandos J.C.
Published: August 2019

El envejecimiento poblacional es un hecho de gran transcendencia socioeconómica con importantes repercusiones empresariales. Es importante el análisis del consumidor mayor y de sus particularidades para la consecución de una efectiva comunicación publicitaria. En este trabajo se analizan los antecedentes de la actitud ante el anuncio de las personas mayores y sus consecuencias sobre la actitud hacia la marca y la intención de compra en condiciones de baja implicación con el anuncio. Sobre una muestra constituída por 509 sujetos se confirma el modelo general planteado y se defiende que las personas mayores utilizan conjuntamente las dos rutas de persuasión en el procesamiento cognitivo del anuncio.
Operative morbidity and mortality for colorectal cancer: 10-years’ experience
Authors: Ahmad H. Viqar , Khan Zubair Afzal
Published: August 2019

Background: Operative outcomes for patients with colorectal cancer are heavily dependent on the quality of surgery, the quality of pre-operative staging and treatment selection. The objective of this study was to study the operative morbidity and mortality in patients with colorectal cancer.Methods: The records of patients, with histologically proven colon or rectal cancer and underwent operative procedure, have been prospectively documented. A detailed analysis was made of patients who had a hospital stay of more than 15 days and who died within 30 days of surgical procedure.Results: 311 patients of colorectal cancer were operated. 19 patients died within 30 days of operation, an overall OMR of 6.10%. 50.80% of patients had operative morbidity events. OMR and morbidity was higher in patients undergoing emergency surgical procedure, in elderly patients, in females, patients with poor pre-operative ASA grading and in patients with advanced stages tumour.Conclusions: Adoption of various modalities of have to be considered in perspective of the age of the patient, pre-operative performance status, the type, nature and urgency of operation and pathological stage of the disease which have a bearing on the operative morbidity and mortality.
IAPSM’s Textbook of Community Medicine
Authors: Barwal Vijay Kumar , Sharma Gopal Ashish
Published: August 2019

A great effort by the editor-in-chief, Dr. A. M. Kadri, a well-known academician and teacher as well as the secretary general of IAPSM for more than three years, to compile the work of over 200 authors who are subject experts and teachers of Community Medicine from all over India. This book exhibits expertise of the subject from every nook and corner of India. It is nicely framed and the font size, print, tables, diagrams are reader friendly and pleasing to the eyes.
Revitalisasi Pendistribusian Zakat Produktif Sebagai Upaya Pengentasan Kemiskinan di Era Modern
Authors: Haidir M Samsul
Published: August 2019

AbstractThe purpose of this study was to determine the distribution of productive zakat in the form of venture capital carried out by BAZNAS (National Zakat Agency) as an effort to alleviate poverty in the city of Yogyakarta. The type of research is field research. The research method is qualitative descriptive. The results of the study revealed that the implementation of productive zakat capital had a positive impact on alleviating poverty, increasing income and bring forth new entrepreneurs. Therefore, the program of distributing productive zakat by BAZNAS in the city of Yogyakarta needs to be carried out continuously while improving the quality of the management and the resources.AbstrakTujuan penelitian ini adalah untuk mengetahui distribusi zakat produktif dalam bentuk modal usaha yang dilakukan oleh BAZNAS (Badan Amil Zakat Nasional) dalam upaya pengentasan kemiskinan di kota Yogyakarta. Jenis penelitian yang dilakukan ini adalah penelitian lapangan. Adapun metode penelitian ini bersifat kualitatif deskriptif. Hasil penelitian mengungkapkan bahwa pengimplementasian modal zakat produktif berdampak positif dalam pengentasan kemiskinan, peningkatan pendapatan serta melahirkan wirausahawan baru. Oleh sebab itu, program penyaluran zakat produktif oleh BAZNAS kota Yogyakarta perlu terus dilakukan sembari meningkatkan kualitas pengelolaanya serta sumber dayanya.
Концепции креативной энергии в теории интеллектуального капитала
Authors: Хвецкович Никита Александрович
Published: August 2019

Возникновение на рубеже XX-XXI вв. креативной экономики предопределило появление нового направления в теории интеллектуального капитала, которое оформилось в концепции интеллектуально-креативных ресурсов. В статье рассматривается одно из основополагающих положений этой концепции – феномен творческой энергии. Второй раздел статьи посвящен краткому обзору модели творческой энергии, согласно которой этот вид энергии отождествлен с созидательными действиями индивида. Помимо этого, автор настоящей статьи предлагает для практического применения модель креативной энергии как меры информационного взаимодействия, а также дает этому виду энергии новое определение в рамках предлагаемой им модели. В работе описывается существующий согласно разработанной модели механизм взаимодействия информации, возникающего при протекании творческих процессов, а также рассматриваются основные теоретические, практические и экономические аспекты предлагаемой модели. Делаются выводы о перспективах использования модели креативной энергии как меры взаимодействия информации для разработки подходов к управлению интеллектуально-креативными ресурсами предприятий, а также к оценке экономической эффективности структурного и человеческого типов интеллектуального капитала.
Проблемы современного человека и качество его жизни в цифровой экономике
Authors: Городнова Наталья Васильевна , Самарская Надежда Александровна
Published: August 2019

Принятый российским государством курс на создание цифровой экономики является основной стратегической задачей развития нашей страны. Программа цифровизации экономики – это полное переформатирование всех сфер жизни российского общества. В этой связи проблема адаптации отдельного человека к условиям быстро меняющегося мира, внешней среды принятию вызовов и угроз неопределенности и риска, которые неизбежно сопровождают человека на протяжении всей его жизни, становится еще более актуальной в цифровой среде. Статья посвящена выявлению позитивных и негативных внедрения цифровых и платформенных технологий последствий для личности и ее качества жизни. Делается вывод о том, что наряду с несомненными положительными результатами повсеместного применения информационных технологий в жизни общества могут возникнуть проблемы философского-психологического характера, в частности проблема идентификации и самоидентификации человека в цифрово-информационном мире.
Возможности современных инструментальных средств моделирования бизнес-процессов
Authors: Ковылкин Дмитрий Юрьевич , Новикова Василиса Николаевна , Ратафьев Сергей Васильевич
Published: August 2019

В настоящее время активно развивается моделирование бизнес-процессов и создаются различные инструментальные средства, позволяющие автоматизировать этот процесс. Статья посвящена сравнительному анализу возможностей современных инструментальных средств моделирования бизнес-процессов. Рассмотрены инструментальные средства моделирования бизнес-процессов в нотациях BPMN, eEPC и IDEF. В частности, рассмотрены такие инструментальные средства моделирования бизнес-процессов как ARIS Express, Bizagi Business Process Management Suite, Bizagi Modeler, Business Process Simulator Community, Draw.io, ELMA Business Process Management, Gliffy, Visual Paradigm и Business Studio
El mercado de factura electrónica - justificación de su creación legal desde el Análisis Económico del Derecho
Authors: Rojas Arias Juan Camilo
Published: August 2019

El presente artículo de investigación es el resultado de la reflexión personal del autor acerca de los factores económicos y jurídicos que impulsaron al Gobierno de Colombia –Ministerio de Comercio, Industria y Turismo– a expedir un serie de normativas encaminadas a la creación de un mercado electrónico de facturas. El presente estudio descriptivo y explicativo se desarrolla bajo el análisis de la normativa expedida sobre el particular y sobre las condiciones de mercado existentes, haciéndose evidente un bajo nivel de inclusión financiera, así como el problema generalizado en la obtención de financiamiento externo por parte de las pequeñas y medianas empresas en Colombia, lo que impulsó una política pública de intervención en los mercados a fin de corregir las fallas expuestas, buscando generar fuentes alternativas de financiamiento para el segmento de pequeñas y medianas empresas en Colombia.
Sophia – the Personification of Divine Wisdom in the Culture of Novgorod the Great from 13th to 15th Century
Authors: Brzozowska Zofia
Published: August 2019

The idea of Sophia – the personified Wisdom of God served as a symbol of independence and identity of the republic in the political culture of Novgorod the Great. In Old Russian chronicles and other narrative sources which can be connected with Novgorod, one may find statements showing that – in the eyes of the Novgorodians themselves – Wisdom was not only one of the main attributes of God, but also a separate character, a kind of divine being, who could be interpreted as patronesses and supernatural protector of the city-state. Construction of the temple of Hagia Sophia in Novgorod is usually dated to 1045–1050. In the source material one can find information that Novgorodian Sophia church was undoubtedly the most significant and important monument in the city. The theme of Wisdom of God is also a very prominent topic in Novgorodian historiography and literature. Moreover, the feminine personification of God’s Wisdom can also be found on the coins, emitted by the city-state from 1420.
Сведения о дуалистических ересях и языческих верованиях в "Шестодневе" Иоанна Экзарха
Authors: Минчев Георги , Сковронек Малгожата , Петров Иван Н.
Published: August 2019

The article aims to present and analyze those passages of the Hexameron (Šestodnev) in which ‘heretics’, ‘Manichaeans’, ‘pagans’ or ‘pagan Slavs’ are mentioned. The fragments are compared with their Greek counterparts (as long as these exist); the Old Bulgarian texts (especially those that can be considered original additions or loose compilations) are utilized for interpreting certain elements of heterodox doctrines common to Manichaeism, Paulicianism, Massalianism and Bogomilism. The Old Bulgarian translation/compilation by John Exarch supplies important information on the cosmology, theological doctrine and liturgical life of the Neo-Manichaeans within the Byzantine- Slavic world. The original additions and passages that can be seen as loose translations or compilations testify to the relevance of anti-dualist polemics even in the later periods of the Byzantine-Slavic religious community. The old Gnostic and Manichaean concepts, adapted by later dualist heresies (as e.g. Massalianism and Paulicianism), coupled with Trinitarian and Christological deviations from the official dogma, infiltrate the 1st Bulgarian Empire and provide a hospitable environment for the appearance of Bogomilism. In this sense, the Old Bulgarian Hexameron turns out to be an important source of information on the predecessors of the ‘Bulgarian heresy’. The original additions and loose translations/compilations of certain passages uncover some ‘common areas’ characteristic of all medieval Neo-Manichaean doctrines: the dualist creation myth, the belief in Satan as God’s ‘first-born son’ and the related Trinitarian and Christological departures from the prescribed dogma. Especially noteworthy is the passage referring to the Trisagion (Trisvetoe). The rejection of particular elements of the Liturgy of the Faithful attests to the dualists’ more diversified attitude towards the official ritual – not an indiscriminate renunciation, but the exclusion of those elements that were considered to praise the Old Testament God and to be irreconcilable with the Neo-Manichaean beliefs concerning creation and forgiveness. The mentioning of a Slavic pagan sun cult should be analyzed not only in connection with the charges against Manichaeans and Slavs concerning idolatry, but also in a wider context of the refutation of antique astrological beliefs and soothsaying practices. The comparison of particular lexemes, phrases and larger textual units in John Exarch’s Hexameron on the one hand and the Sermon Against the Heretics on the other makes it possible to conjecture that Cosmas the Priest was familiar with his predecessor’s work and made use of it when composing his own anti-heretic text.
Несколько замечаний о необычной славянской редакции "Видения апостола Павла" из рукописных cобраний в Польше
Authors: Страдомский Ян , Иванова Мария
Published: August 2019

The apocryphal Apocalypse of St. Paul the Apostlebelongs to the group of early-Christian texts which exerted significant impact on people’s perceptionof the nether world and the Last Judgment. In the Middle Ages, the text was known in the area ofwestern and eastern Christian literary tradition. Numerous translations also include the renditionof the Apocalypse of St. Paul the Apostle into Church Slavonic, made in Bulgaria between the 10thand the 11th century, whose presence and distribution in the area of southern Slavdom and Rutheniais confirmed by copies of manuscripts. The article is devoted to a manuscript of the Apocalypse ofSt. Paul the Apostle hitherto overlooked in studies, whose unique form supplements and makes theSlavic textual tradition of the manuscript more comprehensible. The unique feature of the discussedcopy is supplementation of the text with an ending, present only in the ancient Syrian and Coptictranslations of the apocryphal text.
Autoproscoptae, Bogomils and Messalians in the 14th Century Bulgaria
Authors: Wolski Jan Mikołaj
Published: August 2019

This paper discusses the use of the names of heresies: bogomilism, messalianism and the heresy of autoproscoptae in 14th century Bulgarian sources. The author underlines that the names of bogomilism and messalianism do not always refer to dualism. Two wider unknown examples of such use of the name “messalinism” are recalled. In the Pseudo-Zonaras Nomocanon (CIAI 1160), the name “messalianism” is treated as being equal to the “heresy of autoproscoptae”. In the Rule for hermits, messalians are presented not as heretics, but as monks disregarding their rules.
Centones gongorinos en Nueva España
Authors: Tenorio Martha Lilia
Published: August 2019

The poetic form known as cento, composed of sections or verses of other poems, represents a curious literary subgenre practiced since Classical times. In New Spain, we have examples of Virgilian centos, centos about Our Lady of Guadalupe, and Gongorian centos on the Immaculate Conception. This article contains both a brief introduction on this poetic form and the textual edition of the six Gongorian centos that were composed in New Spain.
EFICACIA DE LA APLICACIÓN DE LA NORMATIVIDAD PROTECTORA DE LAS HICOTEAS (Trachemys venusta) EN TABASCO
Authors: Gómez Aguilar Virgilio , Ramos Ferrer Jesús Antonio , Mendiola Campuzano Jorge Víctor Hugo
Published: August 2019

Se trata de un análisis cualitativo a través de una metodología mixta auxiliada del positivismo jurídico. Haciendo énfasis en aquellos decomisos de hicoteas de los cuales hacen eco los medios de comunicación como parte de la labor conservacionista de la especie. El objetivo fue iniciar una teorización sobre el fenómeno del tráfico de especies como la hicotea en municipios de Tabasco, en un contexto poco documentado, buscando ponderar el cumplimiento de las normas después del decomiso y la reinserción a su hábitat original o algún otro adecuado. La metodología mixta se nutrió de la lógica jurídica en sus vertientes deductiva y epistemológica destacando de este lo analítico y sintético de las notas periodísticas y el contraste con la legislación en materia de preservación de especies como complemento del mismo. Los resultados encontrados sitúan el estado de cosas en Tabasco y el destino final de especies como la Hicotea.

Palabras clave: Derecho, Tráfico, Tortugas.
Keywords: Law; traffic; turtles.
8vo CONGRESO NACIONAL DE INVESTIGACIÓN EN CAMBIO CLIMÁTICO, SEDE PENÍNSULA
Authors: Gama Campillo Lilia María , Padrón López Rosa Martha
Published: August 2019

Debido a los impactos que se están viviendo en diferentes partes del mundo asociados al calentamiento global, el tema de cambio climático está como prioridad en la agenda muchos países y México no es la excepción. Los primeros comunicados del Panel Intergubernamental de Cambio Climático iniciaron señalando las amenazas que se podían identificar, lo que se ha traducido en un interés de investigación de los académicos, que a la vez requiere desarrollar estrategias para aprender cómo enfrentarlo localmente. Cabe destacar, que este evento, debido a la complejidad del tema, buscaba especialmente fortalecer colaboraciones, y dar oportunidad a la generación de nuevas sinergias de trabajo.
¿SON LOS MODELOS DE DISTRIBUCIÓN POTENCIAL UNA HERRAMIENTA CERTERA DE LA BIOLOGÍA DE LA CONSERVACIÓN?
Authors: Rosique de la Cruz Yazmin del Carmen , Valdez Leal Juan de Dios , Pacheco Figueroa Coral Jazvel , Gama Campillo Lilia María , Moguel Ordóñez Eduardo Javier , Rangel Ruiz Luis José , Hernández Sánchez Francisco Javier
Published: August 2019

Los seres humanos han transformado el entorno según sus necesidades, dejando un paisaje muy variado. Las actividades antropogénicas son la causa más importante en la disminución de especies, debido a la reducción y pérdida de hábitat. Un factor más que está afectando directamente a las poblaciones e individuos es el cambio climático. Se estima provocará entre el 20 y 30 % la extinción de muchas especies de plantas y animales. En años recientes, los modelos de distribución de especies (SDMs) han sido ampliamente utilizados para identificar el efecto del cambio climático en plantas y especies animales. Los SDMs pueden ser una herramienta muy útil en la toma de decisiones para la conservación de áreas y ecosistemas por parte de los diferentes órganos de gobierno o por las instituciones internacionales, pero con ciertas incertidumbres.
Modal Sosial dan Persepsi TIK dalam Pembangunan Desa Perbatasan
Authors: Rumata Vience Mutiara , Nelar Olivia , Sakinah Awit Marwati
Published: August 2019

This is an explanatory research which aims to find out the relationship between social capital – bridging and bonding – to the perception on ICT for rural community in the border area. This study uses quantitative method by using questionnaires in Kifu Village, Kupang Regency, East Nusa Tenggara. The systematic random sampling method was applied in the population of adolescent aged 16-18 years old. The result is that bridging and bonding social capital has a significant effect on the perception on ICT for rural development with R2 values of 33.2%. Non-social capital factor such as internet self-efficacy has impact on youth perception toward ICT for rural development.
Makna Diri Penyandang Oligodaktili
Authors: Sulaeman Sulaeman , Mulyana Deddy
Published: August 2019

Indonesia is a developing country, a population of more than a quarter of a billion people with a variety of health problems, including oligodactyly sufferers in the Village of Ulutaue, Bone Regency, South Sulawesi. They are different from normal people in the surrounding environment. The symbol "self-identity" is given by a normal person in everyday life. The purpose of this research is to find out and explain the self-meaning oligodactyly sufferers. The method of this research is communication phenomenology, examines the experiences with communication and interaction of natural oligodactyly on the surrounding environment. This research uses a qualitative approach based on the subjective interpretive techniques of data collection through interviews and participatory observations with complementary data based on the perspective of the social action and symbolic interaction. This research involves fifteen subjects with ten men and five women selected by purposive. The results of this research categories such as physical abnormalities and form a physical organ. The selfmeaning of physical abnormalities on the fingers, such as spirit-self, optimistic of abandonment, despair, closed, and lazy. The self-meaning of forms a physical organ with oligodactyly sufferers since birth, such as inflicting shame-self, deserve our pity, willpower hard work, patience, and a driving passion.
Nonverbal Communication of Candidates in Regional Head Election of West Java Region 2018
Authors: Besman Abie , Adiputra Andika Vinianto , Saputra Sandi Jaya
Published: August 2019

The face of politics in Indonesia is enlivened by the hustle and bustle of non-verbal communication games as part of political discourse. Also through non-verbal communication, politicians mobilize all potential to strengthen the message and political meaning. West Java is one of the regions that will hold the Simultaneous Local Election in 2018. Non-verbal communication is certain to be present as a form of imaging and voice pulling by the candidates who will fight in the West Java regional election. This study defines the meaning behind nonverbal communication displayed by candidates in West Java. This research analyzes various forms of nonverbal communication, visual cultural codes, and refers to the design of visual communication texts. The purpose of this study is to identify nonverbal communication skills of regional head candidates, to identify interpretations of political constituents on nonverbal communication presented by regional head candidates, to identify the KPU's rules and understanding as regulators in interpreting nonverbal communication presented by candidate pairs of regional heads in 4 the location of the 2018 West Java Regional Election. The method used is semiotic analysis of Roland Barthes is to dismantle denotations, connotations and myths by showing every aspect of the symbol that is raised. The conclusions in the nonverbal communication research that are most appropriate in the contestation of the election of the Governor and Deputy Governor of West Java 2018 are the most natural communication and represent the pockets of voters while negating who they are in the political arena of the 2018 West Java Election.
Neurocognitive deficits in clinical polymorphism of schizophrenia: typology, expression and syndromal overlaps
Authors: Kornetov A. N. , Kornetova E. G. , Golenkova A. V. , Kozlova S. M. , Arzhanik M. B. , Samoylenko Zh. A. , Boiko A. S. , Semke A. V.
Published: August 2019

Objective.The authors tried to identify the typology, severity and overlap of neurocognitive deficits with positive/negative symptoms in patients with schizophrenia.Materials and methods.Fifty patients aged 22–55 years (25 women (50%) and 25 men (50%)) with schizophrenia diagnosed according to ICD-10 were examined. The average age was 38.0 ± 4.8 years, the average age of onset was 23 ± 3.2 years, the average disease duration was 15 ± 3.7 years. The patients were examined using battery tests to quantify their cognitive functions: Trail Making Test A&B; Stroop Color Word Interference Test; Verbal Fluency; Benton Visual Retention Test; 10 words learning; WAIS Digit Symbol Test; and WAIS Trail Making Test. The evaluation of cognitive deficits was carried out using z-scales. Association of neurocognitive deficits with other schizophrenia symptoms was also estimated using PANSS. The control group that was formed on the basis of the cognitive sphere parameters included 50 healthy volunteers. Statistical processing was carried out using the Mann–Whitney U test, k-means clustering, and the Kruskal-Wallis one-way analysis of variance.Results.The patients with schizophrenia and healthy individuals had significant differences in the second part of the Stroop Color Word Interference Test, both parts of the Verbal Fluency, average score of Benton Visual Retention Test, 10 words learning basedon 5 reiterations, WAIS Digit Symbol Test and WAIS Trail Making Test withp< 0.05; in the Trail Making Test B withp< 0.01. The cognitive sampling profile was determined and compared with the PANSS scores. The significant predominance (p< 0.05) of the symptoms across all scales was found with impaired attention, visual memory, performance function, and/or orientation/coordination, as opposed to the other manifestations of cognitive deficits.Conclusion.Neurocognitive deficits form syndromal overlaps with positive and negative schizophrenia syndromes, and the presence of attention, visual memory, performance and orientation / coordination disturbances is associated with the severity of schizophrenia in general.
Electrophysiological remodeling of the right ventricle in experimental heart failure of different etiologies
Authors: Tsvetkova A. S. , Krandycheva V. V. , Kharin S. N.
Published: August 2019

The aim of the study was to evaluate electrophysiological remodeling of the right ventricle in rats in experimental heart failure of different etiologies. Materials and methods. Isadrin-, doxorubicin- and monocrotaline-induced heart failure models were developed. Unipolar epicardial electrograms of the ventricles (256 recording sites) were recorded using a 144-channel system. The cardiac output and pressure in both ventricles of the heart were measured. Activation-recovery intervals were used as an index of duration of local repolarization, and the general and local dispersions of activation-recovery intervals were used as an index of heterogeneity of ventricular repolarization. Results. In all models of heart failure, the following were identified: 1) non-uniform prolongation of repolarization with the greatest elongation at the apex of the right ventricle; 2) an increase in apicobasal differences of repolarization with the greatest change in the right ventricle; 3) an increase in the heterogeneity of the repolarization of the epicardial layer of the ventricles with heterogeneous changes in the local heterogeneity of repolarization and a decrease in the interregional differences in the heterogeneity of the electrophysiological properties of the myocardium; 4) more pronounced changes in the repolarization of the right ventricle than in the repolarization of the left ventricle. Conclusion. Thus, irrespective of the cause of the heart failure, the following changes occur: 1) prolongation of the right ventricular repolarization occurs non-uniformly (mostly due to the apical area), which results in an increase in the right ventricular repolarization heterogeneity; 2) an increase in the heterogeneity of right ventricular repolarization is observed, which causes an increase in the overall heterogeneity of the ventricular epicardial surface.