bluuebunny/crossref_metadata_2025 huggingface dataset:
Policy analysis of nutrition education programs in Indonesia: A literature study on the nutrition-conscious family program (Kadarzi)
Authors: Meirna Dewita Sari
Published: December 2024

Nutrition education is a crucial strategy to address the Triple Burden of Malnutrition in Indonesia, which encompasses undernutrition, overnutrition, and micronutrient deficiencies. This study aims to analyze the policies and implementation of the Nutrition-Conscious Family Program (Keluarga Sadar Gizi or Kadarzi) in Indonesia, focusing on identifying challenges and proposing improvements. Using a literature review methodology, this research evaluates the program's strengths, weaknesses, and effectiveness in promoting balanced nutrition behavior. Key findings indicate that while Kadarzi is effective in raising awareness about balanced nutrition, its implementation is hindered by inadequate health workers, limited funding, and insufficient cross-sectoral coordination. Furthermore, many activities remain undocumented, and uneven resource distribution affects the program's reach. Strategies for improvement include enhancing nutrition education, leveraging cross-sector partnerships, and increasing training for health cadres. The study concludes that tailored nutrition education programs, based on research and community needs, are essential for achieving better nutritional outcomes in Indonesia. Strengthening the Kadarzi program can significantly contribute to addressing persistent nutritional challenges and improving public health.
Review on development and evaluation of ibuprofen gel by using natural polymer
Authors: Vaibhav Shankar Lokhande  , Mangesh Atmaram Khote  , Nikhil Nandusing Chavhan  , Prathamesh Sunil GoreGanesh Gopichand Gore  , Kishor Rodge  , R. H. Kale
Published: December 2024

The investigation focuses on developing and review of a topical gel that contains the painkiller Ibuprofen a nonsteroidal anti-inflammatory medication NSAIDS propylene glycol and Alovera gel or Guar gum were used as penetration enhancers to promote penetrate into the skin and as a gelling agent in the preparation of the gel to guarantee strength physical characteristics such as ph viscosity and appearance were assessed experiments on the releasing of substances within the body using flow-through diffusion cell demonstrated a prolonged release profile and experiments on skin permeation demonstrated efficient absorption tests for stability verified that the gel kept its characteristics under many circumstances the findings imply that this transdermal gel formulation presents a viable substitute for Ibuprofen delivery improving patient compliance by means of non-invasive administration more in vivo research is advised to confirm the therapeutic efficacy and safety of this intervention the investigation focuses on developing and review of a topical gel that contains the painkiller Ibuprofen a nonsteroidal anti-inflammatory medication nsaid propylene glycol and Alovera gel or Guar gum were used as penetration enhancers to promote penetration into the skin and as a gelling agent in the preparation of the gel to guarantee strength physical characteristics such as ph viscosity and appearance were assessed experiments on the releasing of substances within the body using flow-through diffusion cell demonstrated a prolonged release profile and experiments on skin permeation demonstrated efficient absorption tests for stability verified that the gel keptits characteristics under many circumstances the findings imply that this transdermal gel formulation presents a viable substitute for Ibuprofen delivery improving patient compliance by means of non-invasive administration more in vivo research is advised to confirm the therapeutic efficacy and safety of this intervention.
Analysis of the relationship between physical activity and cognitive function among elderly residents in nursing homes
Authors: Afrahatul Muslimah  , Musrifatul Uliyah  , Martini Sri W  , Abdul Aziz Alimul Hidayat
Published: December 2024

This study aims to analyze the relationship between physical activity and cognitive function in elderly residents at a nursing home in Surabaya. The research employed a cross-sectional design with a sample of 76 respondents selected randomly. Physical activity was measured using the Physical Activity Scale for the Elderly (PASE), while cognitive function was assessed using the Mini-Mental State Examination (MMSE). The results indicated that the majority of respondents had moderate levels of physical activity (55%) and cognitive function (45%). Spearman Rank correlation analysis revealed a significant relationship between physical activity and cognitive function (p = 0.003). This relationship suggests that increased physical activity is associated with improved cognitive function in the elderly. These findings underscore the importance of implementing structured physical activity programs as a non-pharmacological approach to maintaining cognitive health and enhancing the quality of life among the elderly.
US intellectual property law and its impact on business: Recent developments and trends
Authors: Geraldine O. Mbah
Published: December 2024

Recent developments in United States intellectual property (IP) law have significant implications for businesses, shaping innovation, competition, and market dynamics. Intellectual property rights (IPRs), including patents, trademarks, copyrights, and trade secrets, are pivotal to safeguarding innovation and fostering economic growth. Recent legislative and judicial changes reflect an ongoing evolution in IP protections, addressing emerging challenges such as technological advancements, digital transformation, and globalized trade. The America Invents Act (AIA) continues to influence patent filing and litigation strategies, while decisions by the Supreme Court and Federal Circuit courts reshape patent eligibility and fair use doctrines. Businesses face new complexities in balancing protection with innovation, particularly in areas such as artificial intelligence (AI), biotechnology, and e-commerce. Furthermore, the shift toward globalization necessitates alignment with international IP frameworks, compelling businesses to navigate cross-border enforcement challenges and harmonize strategies. The Digital Millennium Copyright Act (DMCA) and evolving interpretations of the Lanham Act highlight the role of US law in adapting to digital disruptions and brand protection in a data-driven economy. Trade secrets are increasingly emphasized, as reflected in the Defend Trade Secrets Act (DTSA), offering enhanced federal protections to combat cyber theft and misappropriation. This review critically examines these legal trends, their business implications, and strategies for compliance and competitive advantage. By exploring case studies and regulatory shifts, it provides insights for business leaders, legal professionals, and policymakers. The study concludes with recommendations for leveraging IP law to foster innovation, mitigate legal risks, and sustain long-term business growth in a competitive landscape.
An Exploration of Verbal Bullying Types and The Role of Bystanders in Affecting Victims' Mental Health
Authors: Sari Desi Purnama , Mariyani  , Miko Aris Temas , Oktviana Annisa
Published: December 2024

This study aims to explore the prevalence and impact of verbal bullying among adolescents, as well as the role of bystanders in these situations. The methodology involved a survey of 93 respondents, with mental health assessment conducted using the Self-Reporting Questionnaire (SRQ) validated by the WHO, which is a reliable tool for measuring mental health in adolescent populations. The findings show that 39.8% of respondents experienced verbal bullying, primarily in the form of hurtful words (57.8%) and name-calling (42.2%), mostly perpetrated by peers (60.2%). Additionally, 44.6% of respondents reported the presence of bystanders during these incidents, with most (51.4%) attempting to help the victims, although a substantial proportion (43.2%) chose to remain silent, reflecting the complex dynamics in bullying situations. Verbal bullying has significant effects on individuals' mental health, as evidenced by 64.9% of respondents reporting mental health issues related to verbal bullying. Furthermore, interviews with 9 selected victims revealed a range of emotions based on bystander behavior, highlighting feelings of anger, sadness, and anxiety when bystanders supported the perpetrator or remained passive, while victims felt relief and gratitude when defended. Importantly, the perspective of bystanders was not examined in this study. While the research focused on the experiences of victims of verbal bullying and the emotional impacts they face, it did not delve into the motivations, feelings, or actions of bystanders. Understanding how bystanders perceive bullying situations and what influences their decisions could provide a more comprehensive view of the dynamics involved in bullying. Future studies could explore these aspects to gain insights into the bystander effect and its implications for both victims and witnesses.
Exploration of Knowledge, Attitude, and Practice of Pharmacovigilance Among HealthCare Professionals: A Cross-Sectional Study
Authors: Tripathi Rashmi , Sachdeva Monika , Mehta Geetika
Published: December 2024

Introduction: To ensure the safe use of pharmaceuticals and the detection of adverse drug reactions, it is essential to have an understanding of pharmacovigilance. Although India is running the Pharmacovigilance Program of India, still the spontaneous reporting rate is very low. There is a requirement to be aware healthcare professionals about the importance of pharmacovigilance. This study is conducted to assess the knowledge, attitude, and practice of pharmacovigilance among healthcare professionals in the Northern region of Uttar Pradesh.
Material and Methods: A cross-sectional study was conceptualized by a Google forms-based questionnaire with 16 questions (08 of knowledge, 05 of attitude, and 03 of practice) a suitable means of assessing the essential knowledge, attitude, and practice of pharmacovigilance. The questionnaire was distributed among the healthcare professionals from March 2024 to April 2024.
Result: 390 pretested questionnaires were circulated among healthcare professionals, and 332 of them were answered by the respondents i.e., the response rate was 85.12 %. Among all the respondents 63.25 % were males and 36.74 % were females. It was observed in this study that healthcare professionals have limited theoretical knowledge about pharmacovigilance. Despite a positive attitude toward the requirement of reporting adverse drug reactions, healthcare professionals showed less reporting practice.
Conclusion: Healthcare professionals lack adequate knowledge and skill in reporting adverse drug reactions but have a positive attitude toward pharmacovigilance programs. Incorporation of adverse drug reaction reporting concepts in education curriculum, training, and voluntary participation of healthcare professionals in adverse drug reaction reporting is very crucial in achieving safety goals and safeguarding public health.
Ipomoea batatas and Artocarpus altilis Particles into Tablets
Authors: Torrens Sotomayor Luis , Velazquez-Figueroa Carlos
Published: December 2024

Introduction: Tablets are solid pharmaceutical dosage forms administered orally, composed of granules subjected to compression. They can be formed from particles (excipients and active ingredients) that deform under pressure. There are several naturally derived particles from agricultural products that are malleable and could potentially be used as excipients in tablet formulation. However, there is a research gap regarding the use of these agricultural products in tablets. This study explored the potential of using chemically unmodified Ipomoea batatas and Artocarpus altilis granules as excipients in tablet formulation.
Method: The research evaluated physical properties and solubility under varying conditions, including cutting methods, binder addition, and compression forces. The experimental process involved drying, milling, binder mixing (Polyvinylpyrrolidone), and tablet compaction. Particle characterization included size distribution, density, morphology, and porosity, while compacted material analysis focused on hardness, friability, disintegration time, and solubility times.
Results: I. batatas particles were spherical with a D50 of 420 µm and 50%-60% porosity. A. altilis particles were irregularly shaped with a D50 of 120–200 µm and 75%-80% porosity. Compacted I. batatas had hardness >4 kgf, friability <1%, disintegration 8-15 min, and solubility 14-18 min. A. altilis had hardness >4 kgf, friability <2%, disintegration 2.5-5 min, and solubility 5-9 min.
Conclusions: Binder addition and compression forces reduced weight loss and increased hardness, disintegration, and solubility times. The carbohydrate (mainly starches) composition significantly affected solubility time, while cutting technique influenced drying time, but not the final product behavior. This study demonstrates the feasibility of using granular materials obtained from natural agricultural products to form compressed products.
Contribución de los Farmacéuticos Comunitarios en la detección y notificación de reacciones adversas en Andalucía
Authors: Romero Pérez Miguel , Sánchez Polo Manuel , Ayala Ortiz José Alberto , Contreras Aguilar Blanca , Zarzuelo-Romero María José
Published: December 2024

Introducción: La evaluación del perfil de seguridad de un medicamento es crucial tras su comercialización, especialmente en relación con las reacciones adversas a medicamentos (RAM), durante los primeros años. En España, el Sistema Español de Farmacovigilancia de Medicamentos de Uso Humano recoge, analiza y procesa las sospechas de RAM notificadas por profesionales sanitarios, la industria y pacientes, contribuyendo a la salud pública. Los farmacéuticos comunitarios, debido a su contacto directo con los pacientes, son claves para identificar y reportar RAM, mejorando la calidad asistencial. Sin embargo, existen pocos estudios sobre la eficacia de la farmacovigilancia en la farmacia comunitaria. Este estudio analiza las sospechas de RAM notificadas por farmacéuticos comunitarios al Centro Andaluz de Farmacovigilancia en los últimos 20 años, enfocándose en las características de los pacientes y los subgrupos terapéuticos involucrados.
Método: Se realizó un estudio observacional longitudinal de las sospechas de RAM detectadas y notificadas por farmacéuticos comunitarios mediante tarjeta amarilla entre 2003 y 2023.
Resultados: La tasa de notificación de RAM por farmacéuticos comunitarios fue baja (8,3 %) comparada con otros profesionales. Esto parece relacionado con factores como complacencia, falta de conciencia o subestimación de la gravedad de las RAM. Los adultos (18–65 años) presentaron la mayor tasa de notificaciones, siendo la mayoría “no graves”. Los principales grupos terapéuticos involucrados fueron antihipertensivos, antibacterianos, agentes modificadores de lípidos y analgésicos.
Conclusiones: Integrar mejor la notificación de RAM en la práctica farmacéutica y ampliar el acceso a actividades de farmacovigilancia podría aumentar la participación de los farmacéuticos, mejorando la seguridad tras la comercialización.
La International Collaboration of Pharmacy Journal Editors (ICPJE) se constituye formalmente para fomentar la calidad en torno a las publicaciones de investigación sobre farmacia práctica, clínica y social
Authors: Alves da Costa Filipa , Fernandez-Llimos Fernando , Desselle Shane , Arnet Isabelle , Babar Zaheer , Bond Christine , Cordina Maria , Garcia Cardenas Victoria , El Hajj Maguy S. , Jacobsen Ramune , Law Anandi V. , Nørgaard Lotte S. , Polidori Carlo , Shcherbakova Natalia , Stewart Derek , Tonin Fernanda S. , Weidmann Anita E.
Published: December 2024

La declaración de Granada fue el resultado de la necesidad de fortalecer la farmacia práctica clínica, social y administrativa como un área de conocimiento que se materialice en la práctica, la investigación y la política. Para ello, un grupo de editores de revistas de farmacia práctica, clínica y social puso en marcha en el año 2022 en Granada una iniciativa para discutir formas de mejorar la calidad de las publicaciones en esta área, y que culminó en el documento denominado Declaración de Granada. Se desarrollaron dieciocho recomendaciones, agrupadas en seis ámbitos principales: 1) uso apropiado de la terminología; 2) elaborar resúmenes impacto 3) necesidad de las revisiones por pares; 4) limitar la dispersión de revistas; 5) uso más efectivo y adecuado de las métricas de impacto de revistas y artículos; y 6) selección por los autores de la revista de farmacia práctica más apropiada para publicar su trabajo. La declaración de Granada ha sido publicada íntegramente en 14 revistas. Este documento pionero tiene sus antecedentes en otras iniciativas similares desarrolladas por académicos de otros grupos de profesiones de la salud, fomentando el concepto de consenso interdisciplinar y avanzando en el paradigma científico.
UTILIZATION OF LOCAL MATERIALS FOR PERMANENT FORMWORK PRODUCTION FOR LOW-RISE BUILDING CONSTRUCTION
Authors: Dikarev K.B. , Movchan O.Yu. , Papirnyk R.B.
Published: December 2024

Problem Statement. Ukraine’s construction industry has been severely impacted after russian full-scale invasion, with more than 167,000 residential buildings destroyed and a significant reduction in the workforce. Additionally, the country faces a massive accumulation of construction waste due to widespread destruction. Traditional construction methods are labor-intensive and costly, further hindered by the shortage of skilled labor. There is an urgent need for innovative solutions to reduce construction time and costs while addressing environmental sustainability by recycling building debris. Objective. This research aims to explore the feasibility of using local materials, such as granite screenings, slag, and recycled concrete, to produce permanent formwork in low-rise building construction. It seeks to evaluate the mechanical properties of these materials through compression and flexural tests, compare the labor and cost efficiency of permanent formwork to conventional systems, and propose methods to optimize the formwork design to reduce construction labor intensity and material costs. Conclusion. The study demonstrated that local materials, such as granite screenings can be used for permanent framework production and reducing final costs. Mechanical characteristics of samples from local materials were tested and the research found some correlations between material density and structural strength in part of samples, indicating that higher-density materials can improve durability. This approach presents a cost-effective and environmentally sustainable alternative for Ukraine’s reconstruction efforts, reducing reliance on skilled labor and mitigating the challenges posed by the war-damaged construction sector.
ON THE QUESTION OF THE RESPONSE TO EMERGENCIES IN THE DNIPROVIAN REGION AND THE MARTIAL STATE IN UKRAINE
Authors: Kulbach A.A. , Bielikov A.S. , Sugak A.O. , Klymenko G.O. , Rahimov S.Yu.
Published: December 2024

One of the most urgent tasks in Ukraine as a whole and the Dnipro region today, during the martial law, is the preservation of life and health of people, protection of material values, enterprises, structures, communications, natural resources, etc. Currently, this is a challenge for people involved in rescue operations, especially when military emergencies are added to man-made and natural emergencies. Fires, radiation danger, chemical danger, dangers on main gas pipelines and electrical networks − all this creates prerequisites for moral, psychological and physical exhaustion of the personnel of the units of the State Emergency Service and the population of the country. Therefore, the constant analysis of the emergence of emergency situations, their causes and consequences allows to improve the provision of operational response to the occurrence of emergencies in the regions. The purpose of the article.  Determination of the main directions of ensuring the functioning of facilities in the territory of the Dnipro region, taking into account the state of war and the presence of potentially dangerous facilities and critical infrastructure facilities in the region. Conclusions. The Dnieper industrial region is one of the important ones in ensuring the functioning of the national economy of the state. The development of effective measures and the provision of prompt response to the challenges of emergencies in the region are the prevention of their occurrence, liquidation and reduction of consequences in the event of their possible occurrence, taking into account the state of war in Ukraine.
ORGANIZATION OF EMERGENCY DEMOLITION WORKS AT AN INDUSTRIAL FACILITY DESTROYED DUE TO MILITARY ACTIONS
Authors: Naumov V.O. , Bilokon A.I.
Published: December 2024

This article examines the technological sequence of emergency demolition works at an industrial facility destroyed by a missile attack. The initial stages of clearing the work area, including the dismantling of destroyed structures and preparing the site for crane installation, are described. Particular attention is given to the use of construction excavators with various attachments for demolition and the potential of long-reach excavators for safe operations at significant heights. The limitations of such equipment in specific conditions are considered, and a developed demolition scheme using a boom extension for excavators is described. Special attention is devoted to the organization of demolition work in areas beyond the reach of cranes. The technology of using specialized trolleys for moving dismantled structures and transporting them to the crane operation zone is described. The sequence of operations for dismantling hazardous panels using suspended platforms and rigging mechanisms is provided. The implementation of these technologies resulted in improved construction equipment efficiency and ensured safety during operations. The article demonstrates innovative solutions for performing demolition works at industrial facilities damaged by military actions. The described technologies can be applied to a wide range of similar facilities, considering their technical condition and the specific conditions of the construction site environment. Purpose of the study. To develop and substantiate effective technological solutions for organizing demolition works at industrial facilities damaged as a result of military actions, using modern automation methods and digital technologies to optimize the process of selecting appropriate demolition methods. Subject of the study. Technological processes and tools for carrying out emergency demolition works at damaged industrial facilities, with a focus on methods for improving work efficiency and safety. Object of the study. Damaged industrial facilities that require demolition or reconstruction under conditions of limited access and heightened danger caused by military actions.
Safety, immunogenicity, and protective efficacy of the intranasal live pertussis vaccine GamLPV in an infant monkey model (Papio hamadryas)
Authors: Kubrava D. T. , Medkova A. Yu. , Matua A. Z. , Kondzariya I. G. , Amichba A. A. , Trapsh Kh. Z. , Gamgiya L. V. , Kulikov S. G. , Sinyashina L. N. , Mikvabiya Z. Ya. , Karataev G. I.
Published: December 2024

INTRODUCTION. The current progressive increase in pertussis incidence and infant mortality rates is due to the insufficient effectiveness of existing vaccines, both in Russia and worldwide. Previous clinical trials showed that healthy adult volunteers developed long-term antibacterial immunity after vaccination with GamLPV, an intranasal recombinant live pertussis vaccine developed by the National Research Center for Epidemiology and Microbiology named after the honorary academician N. F. Gamaleya. Further clinical development of GamLPV in paediatric volunteers, including infants, requires preclinical studies in a newborn monkey model.

AIM. This study aimed to evaluate the safety, immunogenicity, and protective efficacy of the GamLPV vaccine in infant hamadryas baboons (Papio hamadryas) challenged with pertussis after intranasal vaccination.

MATERIALS AND METHODS. The study used 20 hamadryas baboons, including 7 infants aged 1–1.5 months, 7 mothers of these infants, and 6 control animals. The study examined the time course of changes in serum levels of specific IgG antibodies to pertussis toxin (PT) and filamentous haemagglutinin (FHA) by enzyme-linked immunosorbent assay (ELISA), monitored changes in serum levels of Bordetella pertussis antibodies by agglutination immunoassay, and detected B. pertussis DNA in oropharyngeal aspirates by real-time polymerase chain reaction.

RESULTS. Intranasal GamLPV administration to infant baboons induced the production of specific IgG antibodies to PT and FHA (ELISA) and an increase in the total pertussis antibody titre (agglutination immunoassay). GamLPV did not cause any injection site or systemic reactions. There were no changes in complete blood counts and serum biochemistry profiles after vaccination. The protective efficacy of GamLPV against B. pertussis was demonstrated in challenge tests, where immunised animals had no clinical signs or laboratory findings indicative of pertussis in contrast to controls.

CONCLUSIONS. The study demonstrated the safety and immunogenicity of the intranasal live pertussis vaccine GamLPV in newborn hamadryas baboons. GamLPV shows promise in the primary vaccination of infants, the revaccination of children and adults, and the development of herd immunity against pertussis in families.
Preclinical and clinical development of preventive rotavirus vaccines: special considerations
Authors: Korovkin A. S. , Gorenkov D. V. , Soldatov A. A. , Merkulov V. A.
Published: December 2024

INTRODUCTION. Vaccination is recognised as the only effective method for preventing rotavirus disease. Rotavirus remains a leading cause of death in young children, mainly, in developing countries. Currently, oral rotavirus vaccines for infant immunisation are available worldwide, and novel types of rotavirus vaccines are also under development, in particular, in the Russian Federation. However, there are no regulations or guidelines helping developers to design an optimal preclinical and clinical programme for rotavirus vaccines.

AIM. This study aimed to analyse and summarise global experience in planning and conducting preclinical and clinical studies of rotavirus vaccines in order to provide recommendations for national vaccine developers.

DISCUSSION. This study presents an analysis of the available data (and, specifically, the data obtained for the past five years) on all rotavirus vaccines used in the world that have been clinically proven to be effective in preventing severe rotavirus gastroenteritis and reducing the number of hospital admissions due to acute intestinal infections. The effectiveness of rotavirus vaccines varies in different regions of the world and may be lower in developing countries for various reasons. The safety profile of oral rotavirus vaccines is generally considered favourable. Nevertheless, there are still some concerns regarding intestinal intussusception in infants following vaccination. To address the abovementioned problems, researchers, including those in Russia, are developing novel types of rotavirus vaccines, predominantly focusing on inactivated (subunit or recombinant) preparations. For planning and conducting preclinical studies of a rotavirus vaccine, it is advisable to adopt general approaches that involve assessing the acute and chronic toxicity, immunogenicity, and safety pharmacology of the rotavirus vaccine and the virus-neutralising activity of vaccination-induced antibodies. Clinical trials of a rotavirus vaccine should assess its effectiveness in preventing rotavirus gastroenteritis of any severity, hospitalisation, and acute viral intestinal infections of any aetiology in the target age group of young children. Furthermore, it is important to confirm the safety of the rotavirus vaccine and demonstrate the absence of mutual interference with the immunogenicity of the rotavirus vaccine and other vaccines co-administered in the vaccination schedule.

CONCLUSIONS. Preclinical studies of rotavirus vaccines may use standard and generally accept­ed approaches. However, planning and conducting clinical trials requires specific considerations associated with both the nature of rotavirus infection and the national infant vaccination schedule.
Viability assessment of Salmonella enterica subsp. enterica serovar Abony NCTC 6017 in ampoules and vials by the accelerated shelf-life testing method
Authors: Voropaev A. A. , Cidipova O. T. , Fadeikina O. V. , Davydov D. S.
Published: December 2024

INTRODUCTION. A key priority in maintaining a collection of microorganisms is to ensure the stability of characteristics and the viability of microbial cultures during their storage and transport. In addition, some applications of collection strains as control samples require accurate data on the number of viable microbial cells in each sample. Therefore, it is necessary to develop and implement an analytical procedure for predicting the guaranteed shelf life of test strains.

AIM. This study aimed to predict the guaranteed shelf life for test strains in a variety of primary packaging by assessing changes in microbial viability under accelerated storage conditions, with the Salmonella enterica subsp. enterica serovar Abony NCTC 6017 strain as a model organism.

MATERIALS AND METHODS. The study used lyophilised samples of the S. enterica subsp. enterica serovar Abony NCTC 6017 strain deposited in the National Collection of Pathogenic Microorganisms (NCPM) at the Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation. The studied primary packaging types included vacuum-filled borosilicate glass ampoules and 2R lyophilisation vials. The samples were tested for a number of quality attributes (loss on drying, viable cell count, cell viability, colony morphology, and biochemical identification) and subjected to accelerated shelf-life testing at ele­vated temperatures (35–65 °С).

RESULTS. The study did not show any significant differences in the quality of lyophilised samples depending on the type of primary packaging. The authors experimentally determined rate constants for the loss of viability in microbial cultures during storage at elevated temperatures and calculated the rate constants for the storage and transport temperatures and for different types of primary packaging. The predicted time to viable cell count reduction to 10% of the initial level was 19 years for vials and 25 years for ampoules, and the predicted time to 50% viability was 5.8 years for vials and 7.6 years for ampoules.

CONCLUSIONS. The results of this study confirm the applicability of different primary packaging (ampoules and vials) for the lyophilisation and storage of microbial test strains. The data obtained can guide further research and contribute to the development of recommendations for the storage of lyophilised strains in various types of packaging.
Кинетика высвобождения рабепразола из лекарственных форм разных производителей
Authors: Сереброва Светлана Юрьевна , Кургузова Дарья Олеговна , Красных Людмила Михайловна , Колячкина Ангелина Викторовна , Демченкова Eлена Юрьевна , Журавлева Марина Владимировна , Карева Елена Николаевна , Башмакова Елена Борисовна , Лазарева Наталья Борисовна , Прокофьев Алексей Борисович
Published: December 2024

Тест сравнительной кинетики растворения (ТСКР) на сегодняшний день остается незаменимым инструментом исследования поведения лекарственных препаратов in vitro. Это метод, целью которого является установление эквивалентности профиля растворения в условиях, близких к физиологическим в желудочно-кишечного тракте. С помощью двухэтапного ТСКР, моделирующего патологический дуоденогастральный рефлюкс и состояние фармакологической кислотосупрессии, изучена стабильность таблеток референтного (РП) и воспроизведенных препаратов рабепразола натрия (Разо® и ВЛС1) в моделируемых условиях. Количественное определение рабепразола натрия проводили на жидкостном хроматографе Agilent 1200 со спектрофотометрическим детектором. По результатам сравнительной кинетики растворения и расчета фактора сходимости выявлена эквивалентность профилей растворения препаратов РП и Разо® в среде растворения с рН 7 после 2-часовой экспозиции в средах с рН 1,2 и 4,5. Препарат ВЛС1 признан неэквивалентным по профилю растворения препарату РП в связи с существенными различиями в динамике высвобождения действующего вещества в изучаемые среды растворения. Использованная модель патологического дуоденогастрального рефлюкса показала, что лекарственная форма ВЛС1 не обеспечивает сохранность молекул рабепразола в моделированных патофизиологических условиях, характерных для пациентов с кислото- зависимыми заболеваниями.
Consecuencias del Aislamiento social, Preventivo y Obligatorio en la educación en contexto de privación de la libertad. Un estudio de caso sobre el Penal de Devoto
Authors: Dopico María Florencia
Published: December 2024

El presente trabajo tiene como objetivo analizar las repercusiones del Aislamiento Social, Preventivo y Obligatorio (ASPO) decretado en marzo del año 2020 por el poder ejecutivo nacional como consecuencia de la pandemia mundial por el Covid-19, y la consecuente suspensión de las clases presenciales, en la dinámica de la educación en contexto de encierro punitivo y las trayectorias escolares de los alumnos que se encuentran privados de su libertad, tomando como caso testigo el Centro Educativo de Nivel Secundario (CENS) N°24 del Penal de Devoto, última cárcel activa de la Ciudad Autónoma de Buenos Aires.
En búsqueda de garantizar la continuidad pedagógica de los alumnos con sus instituciones educativas, se han generado diversas estrategias pedagógicas, adaptadas a las realidades materiales de cada espacio. En el caso de la educación en contextos de encierro punitivo, se trabajó con materiales de autoaprendizaje y para acreditar el conocimiento de la materia, se realizaron evaluaciones finales por video llamadas. La ausencia física de los docentes en el aula generó una vinculación sui generis con la institución escolar, produciendo un impacto en la dinámica educativa y la trayectoria escolar de esos alumnos. Es por ello que el presente trabajo buscó comprender las repercusiones del ASPO desde la mirada de quienes coordinaron este proceso educativo en el penal y la experiencia docente, en la titánica tarea de garantizar no solo la vinculación con la currícula escolar sino también el contacto con ese espacio educativo implícitamente vedado por fuera de la institución carcelaria.
Pablo Cortés-González, José Ignacio Rivas-Flores y Analía E. Leite-Méndez (2023) Escuela y transformación social. Otra mirada de la organización educativa. Barcelona, España: Octaedro. 177 páginas.
Authors: Martino Andrea Graciela
Published: December 2024

El libro Escuela y transformación social. Otra mirada de la organización educativa, escrito por Pablo Cortés-González, José Rivas-Flores y Analía Leite-Méndez, es una invitación para profundizar en el estudio y el análisis, en las coordenadas epocales actuales, sobre las organizaciones educativas, especialmente las escuelas, y también, es una invitación para conversar, habilitando nuevas preguntas y renovando discusiones y reflexiones, en el campo de las organizaciones educativas.
Pengenalan Insektarium Sebagai Media Pembelajaran dan Entrepeneur Bagi Siswa SMA Negeri 1 Banyuasin II Sungsang
Authors: Novianti Dewi , Dian Mutiara  , Dewi Rosanti  , Kartika Trimin , Marmaini Marmaini , Warsari Dwi , Wahyudi Rizki
Published: December 2024

Lembaga pendidikan sekolah formal, salah satunya yaitu Sekolah Tingkat Atas (SMA/SMK/MA) baik negeri dan swasta, yang dalam pelaksanaan untuk mencapai keberhasilan dalam proses belajar mengajar, saat ini mulai menerapkan program kewirausahaan (entrepreneur) bagi siswa, terutama sejak pandemic Covid-19 melanda. Kabupaten Banyuasin merupakan salah kabupaten yang terdapat di provinsi Sumatera Selatan, secara administratif terletak di kawasan pesisir Sumatera Selatan. Dalam perkembangannya, kawasan ini sudah dapat ditempuh melalui jalur darat, sehingga akses  menuju ke sekolah lebih mudah. Program PkM ini bertujuan untuk memberikan informasi bagi siswa dan guru dalam pembuatan terrarium sebagai pembelajaran kewirausahaan yang didasari dari pelajaran IPA. Kegiatan dilaksanakan pada tanggal 20 November 2023 bertempat di SMAN 1 Banyuasin II Kabupaten Banyuasin. Metode pelaksanaan dilakukan dengan simulasi langsung. Hasil yang dicapai siswa dapat menerapkan teknik pembuatan insektarium sebagai penerapan pembelajaran IPA.
Penyuluhan Hipertensi dan DAGUSIBU Obat Antihipertensi
Authors: Puji Lestari Mardiana , Rusydan Azka Muhammad
Published: December 2024

Hypertension is a non-communicable disease characterized by systolic blood pressure above 140 mmHg or diastolic blood pressure above 90 mmHg based on repeated examinations. This disease is a degenerative disease that can cause damage to the body's vital organs over time. Hypertension sufferers are estimated at 22% of the total population in the world. Hypertension is a global health problem that is quite dangerous and is the main cause of coronary heart disease and kidney disease. Hypertension, or high blood pressure, is also known as the silent killer because, in most cases, patients do not know when they experience high blood pressure because physical examination often shows no signs until complications occur. Proper prevention and treatment will reduce the impact or risk of unwanted complications. This health education activity aims to increase the knowledge and understanding of the Dukuh Beji community about hypertension and the antihypertensive drug DAGUSIBU as a promotional and preventive effort. The method of outreach activities begins with a health examination, namely measuring blood pressure, then a pretest is carried out, which is then continued with the delivery of material and discussion, then ends with a posttest. The results of outreach activities from 26 participants showed that the majority of participants were aged >61, 50%, with female gender 69.2%, and blood pressure in the abnormal range 69.2%. In evaluating the level of knowledge, there was an increase in participants' knowledge. As seen from the results of the pretest before the counseling was carried out, there were still people who had a sufficient level of knowledge of 15.4%. After being given the counseling and given the posttest, the knowledge level of all participants was 100% in the "good" category
Peran Guru Bimbingan Konseling Dalam Meningkatkan Kemampuan Problem Solving Siswa Di MTsS Yati Kamang Mudik
Authors: Dongoran Patima , Afrinaldi Afrinaldi
Published: December 2024

Seorang guru sangat penting untuk pembelajaran, termasuk guru BK. Guru BK sangat penting untuk proses pembelajaran di berbagai jenjang pendidikan. Guru BK di sekolah bertanggung jawab untuk membantu dan membimbing dalam pertumbuhan kepribadian dan kemampuan siswa. Tujuan dari penelitian ini untuk mengetahui Peran Guru BK Meningkatkan Kemampuan Problem Solving Siswa. Penulis Penelitian ini menggunakan metode Kualitatif Deskiptif dengan lokasi penelitian MTsS Yati Kamang Mudik. Adapun sumber data yang digunakan dalam penelitian data primer dan data sekunder. Data primer didapatkan dengan menggunakan observasi, dokumentasi dan wawancara sedangkan data sekunder didapatkan melalui perantara berupa catata, laporan perilaku dan dokumentasi yang terkait dengan tema penelitian informan kunci 1 informan utama 1 informan pendukung 5 orang siswa, maka jumlah informan keseluruhan adalah 7 orang. Dari hasil penelitian ditemukan bahwa peran guru bk dalam meningkatkan kemampuan problem solving siswa Di MTsS Yati Kamang Mudik.  Adapun peran guru bk dalam meningkatkan kemampua problem solving siswa di MTsS Yati Kamang Mudik yaitu: 1. Peningkatan dalam pemecahan masalah siswa. 2 Kemandirian siswa.3  Komunikasi Kerja sama siswa 4. Ketahanan emosional siswa.
Kompetensi Manajerial Kepala Sekolah dalam Perencanaan Peningkatan Mutu Pendidikan di SMK : Kajian Literatur
Authors: Wati Rina , Ernawati Ernawati , Mardizal Jonni
Published: December 2024

This study aims to analyze the role of principals' managerial competence in planning to improve the quality of education in Vocational High Schools (SMK). The method used is the Systematic Literature Review (SLR) by reviewing articles published between 2019 and 2024. The results of the review show that principals with good managerial competence are able to formulate relevant visions, missions, and strategies to improve the quality of education in SMK. These competencies also play a role in resource management, curriculum development, and evaluation of educational programs. However, challenges such as lack of managerial training and limited resources are still obstacles in the implementation of quality planning in several schools. This article provides recommendations for strengthening principals' managerial training programs to support the sustainability of improving the quality of education in SMK.
Pengaruh Model Pembelajaran Kooperatif Tipe Write Around terhadap Hasil Belajar Bahasa Inggris Siswa Kelas IV SD GMIM 92 Bailang
Authors: Monigir Non Norma , Sarudi Regina K. , Wongkar Nofry V.
Published: December 2024

This study aims to determine the effect of the Write Around cooperative learning model on the English learning outcomes of fourth-grade students of SD GMIM 92 Bailang with public space material. The method used in this study is a quantitative method with data analysis using the SPSS program. The subjects of the study consisted of 22 students who were given treatment using the Write Around cooperative learning model. This study used an experimental design with pretest and posttest to measure changes in student learning outcomes. The results of the analysis showed that there was a significant effect of using the Write Around cooperative learning model on improving students' English learning outcomes, especially in understanding public space material. This is evidenced by the results of the t-test (paired sample t-test) which showed a significant difference between the pretest and posttest scores. Based on these findings, the Write Around cooperative learning model can be used as an alternative to improve the English learning outcomes of fourth-grade students of SD GMIM 92 Bailang.
Implementasi Pembelajaran Pendidikan Pancasila Berbasis Tri Kaya Parisudha terhadap Pengembangan Karakter Siswa Sekolah Dasar
Authors: Andin Dwi Pratiwi Kadek , Rika Damayanti Kadek , Luh Putu Nia Mylinda Ni , Ngurah Ardiawan I Ketut
Published: December 2024

The teachings of Tri Kaya Parisudha are applied in Pancasila education in elementary schools with the aim of fostering constructive thoughts, speech, and behavior in order to develop good character in students. Using descriptive qualitative method, this research was conducted at SD Negeri 4 Tegalinggah. Information was collected through literature review, interviews and observations. The findings of this study demonstrate the effectiveness of Tri Kaya Parisudha in fostering character aligned with Pancasila. It consists of three components: Manacika (thinking good), Wacika (speaking good), and Kayika (doing good). This method has been shown to improve students' good attitude both inside and outside the classroom, which contributes to the achievement of the Pancasila learner profile
Analisis Keterampilan Bertanya pada Pembelajaran IPA Siswa Kelas VIII SMP N Sumber Harta
Authors: Ramadhona R. A. , Amin Ahmad
Published: December 2024

The aim of this research is to analysis the questioning skilla of clas VIII students at SMP Negeri Sumber Harta in science learning. In this research, descriptive research methods were used usinga qualitative apporoac, with instruments in the form of observation sheets and interview sheets. The subjectsbin this research were science subject teachers and students of class VIII SMP Negeri Sumber Harta with a sample of 4 students out of 31 students. The results of the analysis of sudents questioning skills in science learning are in the medium category. It can be concluded that students with high ability think science learning is easy, but students with medium ability think science is not too difficult, and students with low ability think it is difficult.
Gaya Kepemimpinan Demokratis Kepala Sekolah dalam Meningkatkan Mutu Lulusan SMK: Studi Literatur
Authors: Jalal Fitri , Ernawati Ernawati , Mardizal Jonni
Published: December 2024

The principal's leadership style plays an important role in determining the quality of graduates of Vocational High Schools (SMK). This study aims to analyze the influence of the principal's democratic leadership style in improving the quality of graduates through a literature approach. The method used is a literature study, by reviewing relevant research published in the last five years. The results of the study indicate that a democratic leadership style that emphasizes collaboration, active participation, and open communication is able to create a conducive school environment for the development of student competencies. Principals who apply this leadership style tend to be more successful in building harmonious relationships with teachers, students, and the community, thus supporting the achievement of better quality education. In addition, democratic leadership encourages increased innovation in learning and character development of students that are in accordance with the needs of the world of work. This study makes an important contribution in identifying leadership values ​​that are relevant to the development of educational policies and practices in SMK.
Ethical Dimensions of Science: Philosophical Perspectives on the Responsibilities of Scientists
Authors: Idris Muhammad , Sinring Abdullah , Anshari Anshari
Published: December 2024

This study examines the ethical dimensions of science, with the aim of exploring how ethics play a role in scientific research and technological development. This study addresses several important issues, such as ethics in human and animal research, the impact of technology on society, and the social responsibility of scientists. In this context, we review various approaches to ethical philosophy, such as deontology, which emphasizes the moral obligation of scientists to act in accordance with ethical principles, and utilitarianism, which focuses more on outcomes that benefit society at large. Furthermore, this study underscores the significance of ethical oversight mechanisms, like ethics committees (Institutional Review Boards/IRBs), in guaranteeing that research adheres to moral standards and does not cause harm to subjects or society. We also discuss ethical dilemmas that arise in modern research and technology, such as genetic engineering, which raises questions about human genetic editing and potential risks to the ecosystem, and nuclear fusion research, which raises questions about the balance between the benefits of clean energy and potential risks to human and environmental safety. This study emphasizes that scientists, despite their focus on scientific objectivity, have a moral responsibility to consider the social impacts of their discoveries.