bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da influência do frênulo lingual posterior no aleitamento materno: ensaio clínico
Authors: Alves Dayanne Oliveira , Guerra Cândida Augusta Rêbelo de Moraes , Sabino Maria de Fátima Pessoa de Araújo , Kozmhinsky Verônica Maria da Rocha , Alencar Thais Costa de , Veras Gabriella Aguiar Rodrigues
Published: May 2023

Objetivo: Avaliar a influência do frênulo lingual posterior no aleitamento materno de bebês. Método: Tratar-se de um estudo longitudinal, de abordagem quali-quantitativa, descritiva e analítica do tipo ensaio clínico com fonte de dados primários. A população estudada foi composta pelas díades mãe-bebê saudáveis, de ambos os sexos, assistidos no Centro de Especialidades Odontológicas do Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, durante o período de setembro a novembro de 2022. A coleta de dados ocorreu a partir da avaliação do frênulo lingual dos bebês, bem como de entrevista com as mães. Os bebês foram divididos em dois grupos para fins comparativos, sendo eles o grupo de bebês de frênulo lingual posterior tipo III de Coryllos (GIII) e o grupo de bebês de frênulo lingual posterior tipo IV de Coryllos (GIV). Resultados: O frênulo posterior tipo III de Coryllos foi encontrado em 65,2% dos bebês, enquanto o tipo IV, em 34,8%. Desses, 56,5% estavam em amamentação exclusiva na primeira consulta e na segunda consulta houve um aumento para 73,9%.  A prevalência das mães que receberam orientações sobre a importância do aleitamento materno durante a gestação foi 52,2%. Conclusão: Ambos os grupos de bebês com frênulo lingual posterior (GIII e GIV) apresentaram dificuldades no aleitamento, sendo mais prevalentes a dificuldade de pega e dor mamária durante a amamentação. Após a consulta inicial, diante da exposição a orientações, bem como ao procedimento cirúrgico da frenotomia lingual, houve melhora no quadro geral do aleitamento em quase totalidade dos casos.
Molecular epidemiology of Toxoplasma gondii in cattle in Korea
Authors: Kim Kyoo-Tae , Seo Min-Goo
Published: May 2023

Toxoplasmosis is a major public health concern, with raw or undercooked meat being the primary source of human infection. Knowledge regarding the molecular epidemiology of Toxoplasma gondii in cattle destined for human consumption in Korea is lacking. The present study aimed to genetically characterize the infectious strains of T. gondii. Overall, 455 cattle blood samples from 84 farms in the Gyeongnam-do (Province) were randomly collected in 2017. Nested PCR analysis revealed that only 3 (0.7%) samples were infected with T. gondii. The B1 gene sequence of T. gondii was observed to be similar (97.3–99.6%) to that of other T. gondii isolates. This is the first study to perform the molecular detection of T. gondii in cattle in Korea. Although the prevalence of infection was low, our findings suggest that cattle present a potential public health issue. It may be crucial to recognize the importance of T. gondii infection in cattle meat.
UTILIZATION OF MODERN METHODS IN MEASURING THE FINANCIAL PERFORMANCE OF THE COMPANY
Authors: JACKOVÁ ANNA
Published: May 2023

Most entrepreneurs associate their financial performance with the achieved financial results. Each of them wants to be the best and the most successful in their industry and they need to achieve the best possible results. Therefore, it is necessary for them to monitor their financial performance. Except traditional methods of evaluating financial performance (financial analysis), they also focus on modern evaluation methods which consider not only accounting but also economic profit which also takes the alternative cost of capital.
To the 150th anniversary of the birth academician Volodymyr Oleksandrovich PLOTNIKOV
Authors: Pekhnyo Vasyl , Omel’chuk Anatoliy , Koval Larisa
Published: May 2023

The article is dedicated to the 150th anniversary of the birth of V.O. Plotnikov is an academician of the Academy of Sciences of Ukraine, a chemist widely known to the scien­tific community, especially in the field of electrochemistry of non-aqueous solutions, the founder of the world-famous Kyiv School of Electrochemistry, which was formed in the 20s of the last century. The article presents the facts of Plotnikov's biography, in particular his studies, the period of his formation as an electrochemist scientist; theoretical and applied research results achieved by him and his followers, which relate to the most progressive for that time provisions on electrolytic disso­ciation, the chemical theory of solutions and the chemistry of complex compounds.
SYNTHESIS AND PHOTOELECTROCHEMICAL PROPERTIES OF SU2O-CU3VO4 COMPOSITE FILMS
Authors: Smilyk Vitaliy , Fomaniyk Sergii , Kolbasov Gennady , Rysetskiy Igor , Danilov Michael
Published: May 2023

Cu2O-Cu3VO4 films were obtained by elect­rochemical synthesis. The analysis of polarization curves and Pourbaix diagrams for copper and vanadium ions made it possible to analyze the possible reactions that occur during the deposition of films. At potentials from 0  to -0.2V, mainly monovalent copper oxide Cu2O with Cu3VO4 impurities precipitated in the working solution. At the same time, there are two competing processes of acidification of the near-electrode layer as a result Cu2O formation reaction and alkalinization as a result of the chemical interaction of Cu2O with HVO42-. The formation of an excess of OH- ions can inhibit the reaction rate of the formation of  Cu3VO4, accelerating the reaction of the formation of Cu2O. Thus, deposition of Cu3VO4 will take place to a lesser extent compared to Cu2O. Accordingly, to increase the yield of  Cu3VO4, an attempt was made to reduce the deposition current, which, according to literature, helps to reduce the effect of the pH change near the electrode layer. Where, as known the critical current limit at change pH starts from  5 or more mA/cm2. For the synthesis of the films, a current of up to 1 mA/cm2 selected, which contributed to the production of the Cu3VO4 - Cu2O composite, as was established further from the analysis of X-ray patterns. It is shown that their photoelectrochemical pro­perties depend on the heat treatment conditions. This is expressed by the difference in the spectral characteristics of the quantum yield and the value of the photocurrent in the samp­les annealed in air and argon. Using the X-ray phase analysis method, it was established that heat treatment in argon contributes to the formation of a Cu3VO4 and Cu2O composite, in contrast to heat treatment in air, where a mixture of CuO and V2O5 oxides is mainly formed. In the film annealed in air due to impact of wide-band oxide compounds, a smaller value of the quantum yield of the photoelectrochemical current and a narrower spectral dependence were observed. The stretching of the spectrum into the region of visible light on the spectral curves of the photocurrent quantum yield is caused by the contribution of copper vanadate with Eg = 1.5 eV. Analysis of photo­current quantum output spectra and X-ray patterns showed that an increase in monovalent copper in the film structure contributes to the growth of photocurrent in the wavelength range of 450-600nm at a potential of -0.2 relative. h.s.e in 2 times. This indicates a positive effect of heat treatment in argon on increasing the efficiency of photocathodes based on a composite of Cu3VO4 and Cu2O for photoelectrochemical cells.
FORMATION OF ACTIVE INTERPHASE ON THE IRON PARTICLES IN C/PVDF ELECTROCHEMICAL SYSTEMS
Authors: Panteleimonov Radyslav , Pershina Katherine , Shcherbatiuk Ivan
Published: May 2023

The possibility of formation of an active interphase on iron particles in C/PVDF has been dictated by the thermochemical reactions of iron and iron oxides in the presence of carbon. The composition with polyvinylidene fluoride (PVDF) changed the redox activity of iron particles and decreased pure iron (Fe0) amount by 0,24 wt. %. The surface properties of various compositions have been characterized by scanning electron microscopy with the analytical mode for determining the relationship between the microstructure and local thermal reactions on the iron particle surface. A relationship between the surface composition, morpho­logy and electrochemical behavior of the Fe/C/PVDF electrodes has been found. Electric current affects the surface morphology and changes it from a mosaic structure to a monolith in atmosphere oxygen. The electrochemical properties of Fe/C/PVDF electrodes have been tested using cyclic voltammetry (CVA). The long air contact (for more than 3 hours) during electrochemical cycling changes the surface structure in the direction of decreasing crysta­llinity. The Fe/C/PVDF electrode can be charge in neutral solutions (pH ~7).
STATE REGULATION OF PRODUCTION AND ECONOMIC ACTIVITIES IN MINING IN THE ARCTIC
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russian Federation, BATTAKHOV PETR
Published: May 2023

The article discusses the issues of state regulation of production and economic activities in the development and extraction of minerals in the Arctic. The main regulatory and legal acts of entrepreneurial activity in the Arctic were investigated. Some aspects of legal regulation of environmental protection and protection are highlighted, relevant in the development and development of deposits in the Arctic for the development of the economy and ensuring the environmental safety of the country. It is necessary to take state measures for further legal study of the protection and protection of the environment during mining in the Arctic, as well as systematize regulatory legal acts in the field of development of the Arctic zone of the Russian Federation.
CTP INSURANCE IN THE LEGAL ASPECT: NEW APPROACHES AND PROSPECTS
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russia, OVCHINNIKOVA YULIA
Published: May 2023

The article notes the relevance to date of the problems of law enforcement in legal relations on civil liability insurance of vehicle owners. The author touches upon the economic and legal aspects of CTP. Judicial practice has been analyzed, gaps in legislation have been identified, and proposals for making appropriate changes have been made. Conclusions. By its legal nature, the subjective right of choice granted by law to the victim, which consists in repairing the vehicle (despite non-compliance with the requirements) or in refusing to fulfill the insurance obligation in kind, is not an opportunity to choose the method of execution, which is understood as monetary or in-kind forms of insurance compensation. For this reason, the insurance obligation for this category of victims (citizens of the Russian Federation who are owners of vehicles registered in the Russian Federation) does not apply to alternative ones. It is necessary to establish clear and exhaustive grounds in the legislation, which are exceptions to the general rule on the form of compensation in kind for a certain category of victims (citizens of the Russian Federation who are owners of vehicles registered in the Russian Federation). The insurance obligation (we are talking, among other things, about CTP) and the legal relationship for compensation of damage in the part in which it is not covered by insurance compensation, are by their legal nature independent obligations.
ENTREPRENEURIAL ACTIVITY IN MODERN REALITIES: PUBLIC-LEGAL AND PRIVATE LEGAL ASPECTS
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russian Federation, MOTURENKO SERGEY
Published: May 2023

The article pays attention to the concept of a model of state regulation of the economy, provides a classification of state response measures to the introduction of the sanctions regime by a number of countries. The necessity of changing the model of state regulation of the economy in the field of business is proved. The relevant measures to change the model of state regulation - of a private and public legal nature - are analyzed. Such measures include increasing the role of unitary enterprises in the Russian economy, expanding the capabilities of non-profit organizations to carry out entrepreneurial and income-generating activities, more effective use of the insurance mechanism to protect the interests of entrepreneurs, as well as the use of compensation as a way to terminate obligations. It is proposed to introduce in Russia a system for preventing consequences associated with risks and a system for preventing harm in construction.
THE PERSPECTIVES OF MILITARY INTEGRATION OF THE EUROPEAN UNION
Authors: GUSEINOV KAMRAN
Published: May 2023

The purpose of the research. The article considers the perspectives of the military integration of the European Union countries in the spheres of security and defense. The author defines the purposes and prerequisites of the integration in these spheres. The strategic documents of the EU such as the Security Strategy of 2003, the Global Strategy of 2016 and the Strategic Compass of 2022 are examined in this article. The article reveals the main features of the EU strategic autonomy and examines the parameters of the EU strategic culture in the field of security and defense. The author assesses the initiatives of the European Union in the field of further strengthening of the security and autonomy. The transformation of the Common Security and Defense Policy (CSDP) has been studied by the author. The Permanent Structured Cooperation (PESCO) project was considered in detail as well as the contribution of the EU countries to this project. Conclusions. As a result of the study, the author concludes that European integration is in the process of qualitative changes that affect the formation of the system of collective security and defense. The EU is increasingly acting as a strength pole, and there is a strategic shift from traditional “soft power” to “hard power”. Under the pressure of external factors and due to the efforts of the major powers of the region, it is possible to achieve the goal of strategic autonomy in the field of security and defense. The EU is becoming a serious actor not only of the regional but also the global security.
THE PROBLEM OF THE “CHINESE THREAT” AND THE INFLUENCE OF CHINA’S “SOFT POWER” ON THE SHAPING OF THE STATE’S FOREIGN POLICY
Authors:   St. Petersburg State University, St. Petersburg, Russian Federation, QU CHANG
Published: May 2023

Along with the growth of economic power, China is gaining more and more influence in the world. Nevertheless, we can say that the distribution and export of foreign culture in China is relatively insufficient. The emergence of Confucius Institutes built bridges between Chinese culture and other states. The article focuses on the role of Confucius Institutes in improving the image and soft power of China. Confucius Institute has become a pioneer in the dissemination of traditional Chinese culture due to its significant value and significance, achieving the transmission and promotion of excellent traditional Chinese culture, completing the exchange and sharing of various cultures and improving its own system of cultural development, achieving its goals through scientific management and functioning beyond expectations, as well as allowing the international community to understand the deeper subtext of Chinese culture.
ABOUT THE LAW OF THE RUSSIAN FEDERATION “ABOUT PRODUCTION SHARING AGREEMENTS” THROUGH THE EYES OF CHINESE SCIENTISTS
Authors:   Shanghai University of Political Science and Law, Shanghai, China, YUE QIANG , FAN SHIYI
Published: May 2023

The adoption and implementation of the Russian Law “On Production Sharing Agreements” marks a significant increase in the openness of the Russian oil and gas sector. The purpose of this law is to encourage and attract more foreign direct investment in the Russian manufacturing sector. In the context of the fruitful results of strategic cooperation between China and Russia, the role of the “Crushed Stone Ballast” of energy cooperation was additionally demonstrated. From the point of view of Chinese scientists, this article analyzes the prerequisites for the introduction of the Russian system of production sharing agreements and the goals of the introduction of the system, and, finally, predicts the trend of cooperation between China and Russia in this area.
WOMEN’S NON-GOVERNMENTAL ORGANIZATIONS IN THE DEVELOPMENT OF SOCIOPOLITICAL ACTIVITY OF WOMEN IN CENTRAL ASIA
Authors:   Institute of Area Studies of Peking University, Peking, China, SHANCHUAN ZHIZI
Published: May 2023

The article deals with topical aspects of the activities of women’s non-governmental organizations of Central Asian countries in increasing the socio-political activity of women in the post-Soviet period. The transformation of the women’s human rights movement is revealed, the role and influence of foreign and international institutions in the initiation of the gender issue as an element of the current political agenda of the development of Central Asian states is noted. In accordance with international trends in the development of the non-governmental sector, including in the post-Soviet space, the empowerment of women occupies an important place in the development of local communities in Central Asia. Based on a comparative analysis of foreign and national women’s NGOs, it is concluded that there is an imbalance in the approach to gender issues, which stimulates a consistent departure from Western liberal feminist attitudes to nationally oriented women’s human rights activism. The problems are identified and the contours of the future development of women’s NGOs in the Central Asian states are outlined.
ON THE ISSUE OF MODELING THE INFLUENCE OF BAUMAN’S “FLUIDITY” ON THE POLITICAL PROCESS
Authors:   Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, Russian Federation, BAKOV ANTON
Published: May 2023

The relevance of the study is determined by the need to understand the dynamics of political processes depending on demographic changes in society. Based on the theoretical foundations of Z. Bauman’s ideas about “fluid modernity” and achievements in the field of molecular dynamic modeling, the author aims to calculate the “coefficient of political viscosity” of society based on its demographic indicators. Without claiming the exclusivity and universality of the proposed model, which does not take into account other factors other than family ties between people, the author admits a high probability of deviations in the accuracy of forecasting political processes and emphasizes the limited scope of the proposed model. The methodological basis of the article is the theoretical developments of Russian and foreign researchers. The work uses general philosophical, socio-humanitarian, as well as methods from the arsenal of physical, mathematical and chemical sciences. The empirical data used in the work are taken from open sources.
PROBLEMS OF MODERN YOUTH POLICY IN RUSSIA: TO THE QUESTION OF INCREASING EFFICIENCY
Authors:   Kuban State University, Krasnodar, Russian Federation, YURCHENKO VIKTOR , ZAVYALOVA OLGA
Published: May 2023

The purpose of this work is to determine the nature of the influence of modern youth policy on the political behavior and types of political activity of young people, the processes of formation of youth citizenship in modern Russia in the context of a new geopolitical reality and information confrontation, the widespread use of new social media and a sharp increase in the role of the media. The problems of value orientations of the Russian youth policy are analyzed, the problem of effective technologies for the formation of a socially responsible political culture of the Russian youth in the conditions of informational confrontation of the actors of the political process is considered.
TRANSFORMATION OF VALUES IN TODAY’S REALITY THROUGH EXAMPLES OF FILM AND TV SERIES CONTENT
Authors:   Institute of Sociology - Branch of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, Moscow, Russian Federation, DUBROVIN VLADIMIR
Published: May 2023

In the article the dynamics and direction of transformation of spiritual and moral values on the example of film and serial content are considered. The author’s conclusion is that creation of the values demonstrated is influenced by legal regulations, wishes of the audience and actions of subjects in sphere of production and purchase of content. The result this combination is content that demonstrates traditional values.
THREE-DIMENSIONAL EXAMINATION AND GUIDANCE STRATEGIES OF ONLINE BEHAVIOR OF “POST-00S” COLLEGE STUDENTS IN CHINA
Authors:   School of Marxism of Shanghai University of Political Science and Law, Shanghai, China, LI XIANYUE , HE XIAO , XU WEI ,   School of Language and Culture of Shanghai University of Political Science and Law, Shanghai, China,   School of Communication and Electronic Engineering, East China Normal University, Shanghai, China
Published: May 2023

The purpose of this work is to elucidate the intergenerational characteristics of online behaviors of Chinese “post-00s” college students, which contain positive and negative factors. To this end, we endeavor to explicate their online behaviors through an empirical viewpoint and a comparative analysis approach. The present paper will outline the intergenerational characteristics of online behaviors from tripartite perspective. First of all, in terms of online social behavior, it evinves the coexistence of diversification and circle stratification, thereby blocking mainstream discourse from intervening. Secondly, in terms of online entertainment behavior, it has increasingly become fanatical and dramatic, impeding the dissemination of mainstream values. Lastly, regarding online learning behavior, it is progressively self-reliant and reciprocal, gradually diminishing intergenerational emotional dependency and shaking the dominant position of mainstream ideology. The dichotomy of their online behaviors is likely to result in the predicament of online behavior anomie, posing challenges to the efficacy of moral education in Chinese tertiary institutions. Confined from the perspective of moral education, to effectively avert the anomie of online behavior among Chinese “post-00” college students, this manuscript will proffer three measures to bolster the efficacy of moral education in Chinese tertiary institutions. One is to augment mainstream discourse intervention and advance online media literacy education. The second is to facilitate the propagation of mainstream values and refine the digital ecosystem. The third pertains to the modernization of moral education’s narrative and spatial structure, culminating in the elevation of mainstream ideology’s prestige.
INSTITUTIONAL ECONOMICS: FROM BASIC CONCEPTS TO CONTEMPORARY CONTRADICTIONS
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russian Federation, KUSHNIR ANDREI ,   A. N. Kosygin Russian State University (Technology. Design. Art),   Russian University of Transport (RUT-MIIT)
Published: May 2023

The purpose of this study is to analyze the evolution and current state of institutional economics, to clarify its subject area, and to identify relevant problems. As a result, it was shown that modern institutional economics is one of the most productive and contradictory scientific fields. On the one hand, by combining the methods of various social sciences, it has offered effective tools for the solution of certain problems, has extended the economic approach to many spheres of life, has promoted the coordination of contradictory economic interests. It took into account the achievements of normative, ethical, informational, evolutionary, game, transactional, contractual and organizational approaches. On the other hand, due to the increased availability of data and the use of computational methods, institutional economics has been enriched by results in the areas of institutional diversity, institutional change, the study of the impact of institutional quality on inequality problems, and the role of individual economic actors. However, the degree of rationality of individual behavior, the impact of economic institutions on increasing imbalances in the distribution of wealth and power, the implementation of mechanisms of institutional change, and the transplantation of effective economic institutions remain debatable.
PROBLEMS OF FAMILY LAW AT THE PRESENT STAGE: THEIR INFLUENCE ON THE PRACTICE OF APPLYING NORMS AIMED AT PROTECTING THE FAMILY AND CHILDHOOD
Authors:   Institute of State and Law of the Russian Academy of Sciences, Moscow, Russian Federation, LETOVA NATALIA
Published: May 2023

Purpose of the study. The article deals with the problems caused by the lack of certainty in the content of the rules of the family type, arising from the insufficient development of the basic categories of family law. Their absence or underdevelopment leads to defects not only in family norms, but also forms an incorrect practice of their application, which does not allow for effective protection of participants in family relations, including children. The author comes to the conclusion that the imperfection of the norms can be eliminated through theoretical research and legislative decisions aimed at enriching the categorical apparatus of family law, as well as through the active use of fictions and presumptions in the field of family relations, which will eliminate the emerging gaps in their regulation and ensure uniform the use of the same terms in meaning, but different in meaning.
CONFLICT OF LAWS REGULATION OF FAMILY RELATIONS WITH A FOREIGN ELEMENT
Authors:   Russian Presidential Academy of National Economy and Public Administration, Moscow, Russian Federation, GASANOV NATIG
Published: May 2023

The article examines the prospects for the development of regulation of family relations with a foreign element by conflict of laws rules. Today, in the context of changing directions of global leadership, the aggravation of both economic and military confrontation, the deterioration of international relations, the division of states into hostile camps, a radical restructuring is needed in the sphere of regulating family relations, which people from different countries enter or have previously entered. The purpose of this study is to determine trends in the modern conflict regulation of family relations complicated by a foreign element. The author shows that the massive use of modern communication opportunities and movements around the world naturally leads to the establishment of transnational family relations, which, due to their properties, require special legal regulation. The author explores the basic approaches formed by the theory of law and practice in the regulation of family relations with a foreign element. The reasons why the conflict-of-laws regulation of family relations in the Russian Federation remains one of the most difficult and problematic for law enforcement are given. The author reveals the main problems of conflict-of-laws regulation of family relations in the Russian Federation, which hinder its effectiveness. Specific ways of solving these problems are proposed. Assumptions are made about the main directions of the future conflict regulation of family relations with a foreign element.
Improving Cancer Epigenetic Therapy; A Glimpse of NRF2
Authors: Kashkoulinejad-Kouhi Tahereh
Published: May 2023

One of the mechanisms used by epigenetic therapy is the elevation of host cell-derived double stranded RNA (dsRNA) baseline levels through overexpression of genomic repetitive elements especially Alu retroelements. The dsRNAs trigger immunogenic responses since immune system cannot distinguish between endogenous and exogenous dsRNAs derived from viral infections; hence called “Viral mimicry response”. These dsRNAs are recognized by pattern recognition receptors (PRRs) such as MDA-5 which further induce inflammatory responses through interferon secretion. However, the response is limited through the function of some editing enzymes such as ADAR1 which destabilizes the formation of dsRNAs and renders the therapy less efficient through attenuating interferon secretion by immune cells. Since, some cancer cells can survive even after ADAR1 inhibition, it is speculated that there might be other mechanism which contribute to dsRNA destabilization. Since dsRNA formation derived from retroelement transcripts mimics viral infections, we tried to review the mechanistic approaches applied during host-pathogen interaction to highlight a possible candidate which might be cogitable for further investigations in epigenetic therapy. dsRNAs produced by RNA viruses are sensed by PRRs and activate nuclear factor erythroid 2 p45-related factor 2 (NRF2) which further downregulates STING protein and attenuates IFN release. RNA viruses such as SARS-CoV-2 have the potential to impair NRF2 signaling and eliminate its inhibitory effect from STING, leading to excessive release of IFNs and destroy pulmonary cells through cytokine release storm (CRS). Here, we briefly explain that NRF2, in a very downstream side of anti-viral response, might be a potential candidate target in combination with epigenetic therapy to circumvent the limitations in cancer epigenetic therapy.
Evaluation of Traditional and Complementary Medicine Applications Used in the COVID-19 Pandemic
Authors: KISKAÇ Neşe , KATRAN Hamdiye Banu , KISKAÇ Muharrem
Published: May 2023

Objective: Traditional and complementary medicine practices have been used to protect and treat physical and mental diseases in different cultures and beliefs from past to present. In this study, it was aimed to determine which of the traditional and complementary medicine applications was used and its effectiveness in the pandemic.

Methods: 979 people aged 18 and over (between 18 and 73) participated in the study. In the online survey, province, age, gender, occupation, education status, marital status, presence of children, presence of chronic diseases, COVID-19 diagnosis status, whether there is a COVID-19 vaccine, awareness of traditional and complementary medicine practices and nutritional and food supplements, utilization has been questioned.

Results: It was observed that no nutritional and food supplements used by the participants before and during the coronavirus pandemic did not reduce the frequency of being diagnosed with COVID-19.

Conclusions: In the study, it was observed that no food and nutritional supplement reduced the frequency of receiving COVID-19. However, in order to evaluate the effectiveness of nutritional and food supplements, it was concluded that the sample of the participants should be equal in terms of occupation, age, whether they were infected or not, and that it should be supported by researches by questioning whether the patients diagnosed with COVID-19 had mild symptoms or not.
HUBUNGAN KEMAMPUAN MEMBACA APRESIATIF DENGAN KEMAMPUAN MENULIS TEKS CERPEN SISWA KELAS VII SMP
Authors: Fitri Rahayu
Published: May 2023

This research aims to describe the significant relationship between appreciative reading skills and the ability to write short stories for seventh grade students of junior high school. This type of research is quantitative research with correlational methods. The data obtained in this study were in the form of scores on the results of measurements on appreciative reading skills and scores on the results of measurements on students' ability to write short story texts. The populations in this study were all class VII students of SMP Negeri 25 Padang, totaling 254 students. The sampling technique used is a simple random technique. In this study, class VII C was chosen as the research sample because this class is a normal and homogeneous class. The numbers of samples in this study were 30 students. The data in this study were analyzed using a simple correlation test intended to test the research hypothesis. Based on the results of the study, it can be concluded that there is a significant relationship between appreciative reading skills and the ability to write short stories for class VII students of SMP Negeri 25 Padang. This can be seen from the results of tcount>ttable or 5.49>1.70.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis
Authors: Alsaikhan Fahad , Mahmoud Mustafa Z. , Suliman Muath
Published: May 2023

Introduction: The metal-organic frameworks (MOF) have shown fascinating possibilities in biomedical applications, and designing a drug delivery system (DDS) based on the MOF is important. This work aimed at developing a suitable DDS based on Denosumab-loaded Metal Organic Framework/Magnesium (DSB@MOF (Mg)) for attenuating osteoarthritis.

Materials and Methods: The MOF (Mg) (Mg3(BPT)2(H2O)4) was synthesized using a sonochemical protocol. The efficiency of MOF (Mg) as a DDS was evaluated by loading and releasing DSB as a drug. In addition, the performance of MOF (Mg) was evaluated by releasing Mg ions for bone formation. The MOF (Mg) and DSB@MOF (Mg) cytotoxicity towards the MG63 cells were explored by MTT assay.

Results: MOF (Mg) characterized by using XRD, SEM, EDX, TGA, and BET. Drug loading, and releasing experiments proved that DSB was loaded on the MOF (Mg) and approximately 72% DSB was released from it after 8 h. The characterization techniques showed that MOF (Mg) was successfully synthesized with good crystal structure and thermal stability. The result of BET showed that MOF (Mg) had high surface areas and pore volume. This is the reason why its 25.73% DSB was loaded in the subsequent drug-loading experiment. Drug release and ion release experiments indicated DSB@MOF (Mg) had a good controlled release of DSB and Mg ions in solution. Cytotoxicity assay confirmed that the optimum dose of it had excellent biocompatibility and could stimulate the proliferation of MG63 cells as time went on.

Conclusion: Due to the high loading amount of DSB and releasing time, DSB@MOF (Mg) can be promising as a suitable candidate for relieving bone pain caused by osteoporosis, with ossification-reinforcing functions.
The clinical implications of fasting serum insulin levels in patients with insulin-treated type 2 diabetes: a cross-sectional survey
Authors: Zhou Lingli , Luo Yingying , Wang Yan , Cheng Yao , Zhang Rui , Zhang Simin , Gong Siqian , Han Xueyao , Ji Linong
Published: May 2023

Objective

This study aimed to investigate the clinical implications of fasting serum insulin (FINS) levels in subjects with type 2 diabetes who were receiving insulin therapy.

Methods

A total of 1,553 subjects with type 2 diabetes [774 subjects who had never received insulin treatment (N-INS) and 779 subjects who were receiving insulin therapy (constant insulin treatment, C-INS)] admitted to the Department of Endocrinology and Metabolism of Peking University People’s Hospital were enrolled in this study. Their FINS levels were measured and those with hyperinsulinemia were identified. The underlying mechanisms of hyperinsulinemia were revealed by measuring insulin antibodies (IAs) and analyzing changes in FINS levels before and after polyethylene glycol (PEG) precipitation. In addition, the clinical characteristics of patients with different types of hyperinsulinemia were compared.

Results

Higher FINS levels and a higher incidence (43.8%, 341/779) of hyperinsulinemia (FINS > 15μIU/mL) were observed in subjects with C-INS than in subjects with N-INS. Among subjects with C-INS and hyperinsulinemia, 66.9% (228/341) were IAs positive, and the incidence of IAs was found to be positively associated with FINS level. By performing PEG precipitation, we found that all subjects without IAs (i.e., those with real hyperinsulinemia) and 31.1% of subjects (71/228) with IAs (i.e., those with both real and IAs-related hyperinsulinemia) still had hyperinsulinemia after PEG precipitation, whereas FINS levels in the other 68.9% of subjects (157/228) with IAs were normal (IAs-related hyperinsulinemia) after PEG precipitation. Comparisons between the groups showed that subjects with real hyperinsulinemia showed more obvious insulin resistance characteristics, including higher lipid levels, BMIs, and homoeostasis model assessment2-estimated insulin resistance (HOMA2-IR) index, and were more likely to have hypertension, obesity, and metabolic syndromes (p < 0.05). However, the risk of hypoglycemia and glucose variability increased significantly in subjects with IAs compared with those without IAs. A cutoff of FINS to serum C-peptide ratio (≥ 9.3μIU/ng) could be used to screen IAs in clinical practice with 83.3% sensitivity and 70% specificity.

Conclusions

It is necessary to measure FINS in subjects with C-INS to distinguish between types of hyperinsulinemia, which should help to tailor treatment regimens.
Modelling how curved active proteins and shear flow pattern cellular shape and motility
Authors: Sadhukhan Shubhadeep , Penič Samo , Iglič Aleš , Gov Nir S.
Published: May 2023

Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membrane complexes to protrusive forces, exerted by the actin polymerization that they recruit, provides a mechanism that can give rise to spontaneous membrane shapes and patterns. In the presence of an adhesive substrate, this model was shown to give rise to an emergent motile phenotype, resembling a motile cell. Here, we utilize this “minimal-cell” model to explore the impact of external shear flow on the cell shape and migration on a uniform adhesive flat substrate. We find that in the presence of shear the motile cell reorients such that its leading edge, where the curved active proteins aggregate, faces the shear flow. The flow-facing configuration is found to minimize the adhesion energy by allowing the cell to spread more efficiently over the substrate. For the non-motile vesicle shapes, we find that they mostly slide and roll with the shear flow. We compare these theoretical results with experimental observations, and suggest that the tendency of many cell types to move against the flow may arise from the very general, and non-cell-type-specific mechanism predicted by our model.
Improving yields by switching central metal ions in porphyrazine-catalyzed oxidation of glucose into value-added organic acids with SnO2 in aqueous solution
Authors: Zhang Quanquan , Li Xin , Wang Xingwang , Huang Xin , Liu Yuncai , Wu Fengshou , Zhang Bingguang , Deng Kejian
Published: May 2023

Photocatalysis has exhibited huge potential in selective conversion of glucose into value-added chemicals. Therefore, modulation of photocatalytic material for selective upgrading of glucose is significant. Here, we have investigated the insertion of different central metal ions, Fe, Co, Mn, and Zn, into porphyrazine loading with SnO2 for access to more efficient transformation of glucose into value-added organic acids in aqueous solution at mild reaction conditions. The best selectivity for organic acids containing glucaric acid, gluconic acid, and formic acid of 85.9% at 41.2% glucose conversion was attained by using the SnO2/CoPz composite after reacting for 3 h. The effects of central metal ions on surficial potential and related possible factors have been studied. Experimental results showed that the introduction of metalloporphyrazine with different central metal ions on the surface of SnO2 has a significant effect on the separation of photogenerated charges, changing the adsorption and desorption of glucose and products on the catalyst surface. The central metal ions of cobalt and iron contributed more to the positive effects toward enhancing conversion of glucose and yields of products, and manganese and zinc contributed more to the negative effects, resulting in the poor yield of products. The differences from the central metals may attribute to the surficial potential change of the composite and the coordination effects between the metal and oxygen atom. An appropriate surficial potential environment of the photocatalyst may achieve a better interactive relationship between the catalyst and reactant, while appropriate ability of producing active species matched with adsorption and desorption abilities would gain a better yield of products. These results have provided valued ideas for designing more efficient photocatalysts in selective oxidation of glucose utilizing clean solar energy in the future.
Ventriculo-arterial (un)coupling in septic shock: Impact of current and upcoming hemodynamic drugs
Authors: Demailly Zoé , Besnier Emmanuel , Tamion Fabienne , Lesur Olivier
Published: May 2023

Sepsis is an archetype of distributive shock and combines different levels of alterations in preload, afterload, and often cardiac contractility. The use of hemodynamic drugs has evolved over the past few years, along with the invasive and non-invasive tools used to measure these components in real time. However, none of them is impeccable, which is why the mortality of septic shock remains too high. The concept of ventriculo-arterial coupling (VAC) allows for the integration of these three fundamental macroscopic hemodynamic components. In this mini review, we discuss the knowledge, tools, and limitations of VAC measurement, along with the evidence supporting ventriculo-arterial uncoupling in septic shock. Finally, the impact of recommended hemodynamic drugs and molecules on VAC is detailed.
Ovarian juvenile granulosa cell tumors with Ollier’s disease in children with IDH1 gene somatic mutation
Authors: Zhang Jin , Hua Renwu , Ma Lishuang , Liu Chao , Zhang Yanxia , Lü Xuemin , Wang Tianren , Wan Naijun
Published: May 2023

Objective

The aim of this study was to explore the symptoms, treatment, and pathogenesis of ovarian juvenile granulosa cell tumors with Ollier’s disease in children.

Methods

From October 2019 to October 2020, clinical data were retrospectively analyzed for one case of ovarian juvenile granulosa cell tumors with Ollier’s disease. Whole-exome sequencing and Sanger sequencing were used to detect gene mutation in ovarian tumor and chondroma tissue. NADP-dependent isocitrate dehydrogenase-1 (IDH1) and S6 ribosomal protein expression levels in cells transfected with wild-type or mutant plasmid were analyzed by Western blot.

Results

The 4-year-old female showed multiple skeletal deformities, bilateral breast development with chromatosis, and vulvar discharge. Sex hormone assay suggested that estradiol and prolactin were elevated, and the x-ray of limbs suggested enchondroma. Pelvic ultrasound and abdominal CT revealed a right ovarian solid mass. Pathologic examination of the right ovarian solid mass showed a juvenile granulosa cell type. A c.394C>T (p. Arg132Cys) mutation of the IDH1 gene was detected in both the ovarian juvenile granulosa cell tumors and enchondroma. Transfection of HeLa cells with either WT or Mut plasmid caused 4.46- or 3.77-fold overexpression of IDH1 gene compared to non-transfected control cells, respectively. R132C mutation inhibited the phosphorylation of S6 ribosomal protein, which is central to the mTOR pathway. Postoperatively, estradiol and prolactin levels fell to values normal for her age and bilateral breast gradual retraction.

Conclusion

The incidence of ovarian juvenile granulosa cell tumors with Ollier’s disease in children may be caused by generalized mesodermal dysplasia; IDH1 gene mutation may play a facilitated role in this process. Surgical operation is the main treatment. We suggest that patients with ovarian juvenile granulosa cell tumors and Ollier’s disease should undergo regular investigation.
Association of solute carrier family 30 A8 zinc transporter gene variations with gestational diabetes mellitus risk in a Chinese population
Authors: Zeng Qiaoli , Tan Bing , Han Fengqiong , Huang Xiujuan , Huang Jinzhi , Wei Yue , Guo Runmin
Published: May 2023

Background

The solute carrier family 30 A8 zinc transporter (SLC30A8) plays a crucial role in insulin secretion. This study aimed to investigate the impact of SLC30A8 gene polymorphisms on gestational diabetes mellitus (GDM).

Methods

The research objective was to select 500 patients with GDM and 502 control subjects. Rs13266634 and rs2466293 were genotyped using the SNPscan™ genotyping assay. Statistical tests, such as the chi-square test, t-test, logistic regression, ANOVA, and meta-analysis, were conducted to determine the differences in genotypes, alleles, and their associations with GDM risk.

Results

Statistically significant differences were observed in age, pregestational BMI, SBP, DBP, and parity between individuals with GDM and healthy subjects (P < 0.05). After adjusting for these factors, rs2466293 remained significantly associated with an increased risk of GDM in overall subjects (GG+AG vs. AA: OR = 1.310; 95% CI: 1.005-1.707; P = 0.046, GG vs. AA: OR = 1.523; 95% CI: 1.010-2.298; P = 0.045 and G vs. A: OR = 1.249; 95% CI: 1.029-1.516; P = 0.024). Rs13266634 was still found to be significantly associated with a decreased risk of GDM in individuals aged ≥ 30 years (TT vs. CT+CC: OR = 0.615; 95% CI: 0.392-0.966; P = 0.035, TT vs. CC: OR = 0.503; 95% CI: 0.294-0.861; P = 0.012 and T vs. C: OR =0.723; 95% CI: 0.557-0.937; P = 0.014). Additionally, the haplotype CG was found to be associated with a higher risk of GDM (P < 0.05). Furthermore, pregnant women with the CC or CT genotype of rs13266634 exhibited significantly higher mean blood glucose levels than those with the TT genotype (P < 0.05). Our findings were further validated by the results of a meta-analysis.

Conclusion

The SLC30A8 rs2466293 polymorphism was found to be associated with an increased risk of GDM, while rs13266634 was associated with a decreased risk of GDM in individuals aged ≥ 30 years. These findings provide a theoretical basis for GDM testing.
Transcriptome profiling of the initial segment and proximal caput of mouse epididymis
Authors: Wang Xiao , Qiu Fanyi , Yu Junjie , Zhou Meiyang , Zuo Anjian , Xu Xiaojiang , Sun Xiao-Yang , Wang Zhengpin
Published: May 2023

Background

The proximal region of the mouse epididymis plays a pivotal role in sperm transport, sperm maturation, and male fertility. Several studies have focused on segment-dependent gene expression of the mouse epididymis through high-throughput sequencing without the precision of the microdissection.

Methods and results

Herein, we isolated the initial segment (IS) and proximal caput (P-caput) by physical microdissection using anLcn9-cre;Rosa26tdTomatomouse model. We defined the transcriptome changes of caput epididymis by RNA sequencing (RNA-seq), which identified 1,961 genes that were abundantly expressed in the IS and 1,739 genes that were prominently expressed in the P-caput. In addition, we found that many differentially expressed genes (DEGs) were predominantly or uniquely expressed in the epididymis and region-specific genes were highly associated with transport, secretion, sperm motility, fertilization, and male fertility.

Conclusion

Thus, this study provides an RNA-seq resource to identify region-specific genes in the caput epididymis. The epididymal-selective/specific genes are potential targets for male contraception and may provide new insights into understanding segment-specific epididymal microenvironment-mediated sperm transport, maturation, and male fertility.