bluuebunny/crossref_metadata_2025 huggingface dataset:
Employment of a high-throughput functional assay to define the critical factors that influence vaccine-induced, cross-variant neutralizing antibodies for SARS-CoV-2.
Authors: Gu Yue , Shunmuganathan Bhuvaneshwari , Qian Xinlei , Gupta Rashi , Tan Rebecca See Weng , Kozma Mary , Purushotorman Kiren , Murali Tanusya M. , Tan Nikki Y.J. , Preiser Peter R. , Lescar Julien , Nasir Haziq , Somani Jyoti , Tambyah Paul , Smith Kenneth G.C. , Renia Laurent , Ng Lisa F.P. , Lye David C. , Young Barnaby E. , MacAry Paul A. , Wai SCOPE cohort study group Fong Siew
Published: June 2023

The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we describe the development and employment of a new functional assay that measures neutralizing antibodies for SARS-CoV-2 and present longitudinal data illustrating the impact of age, sex and comorbidities on the kinetics and strength of vaccine-induced antibody responses for key variants in an Asian volunteer cohort. We also present an accurate quantitation of serological responses for SARS-CoV-2 that exploits a unique set of in-house, recombinant human monoclonal antibodies targeting the viral Spike and nucleocapsid proteins and demonstrate a reduction in neutralizing antibody titres across all groups six months post-vaccination. We also observe a marked reduction in the serological binding activity and neutralizing responses targeting recently newly emerged Omicron variants including XBB 1.5 and highlight a significant increase in cross-protective neutralizing antibody responses following a third dose (boost) of vaccine. These data illustrate how key virological factors such as immune escape mutations combined with host demographic factors such as age and sex of the vaccinated individual influence the strength and duration of cross-protective serological immunity for COVID-19.
Novel Biphenylidene-Thiopyrimidine Derivatives as Corrosion Inhibitors for Carbon-Steel in Oilfield Produced Water
Authors: Ali Hagar , Shaban Mahmoud , Abousalem Ashraf Salem Elsayed , Ghaith Eslam , Fouda Abdelaziz , Ismail Mohamed
Published: June 2023

Three biphenylidene-thiopyrimidine derivatives were newly synthesized, characterized and their corrosion inhibition effect on corrosion of API 5L X52 carbon steel in oilfield produced water was measured by using electrochemical methods: Potentiodynamic polarization technique and electrochemical impedance spectroscopy (EIS). EIS results using an equivalent circuit to model the corrosion inhibition process were analyzed and discussed. The results of Tafel polarization indicate the tested inhibitors are of mixed-type. The adsorption of these compounds followed Langmuir isotherm. The surface of uninhibited and inhibited carbon steel was investigated by Atomic Force Microscopy (AFM), observing surface improvement when carbon steel samples exposed to inhibited corrosive solution. Quantum chemical calculations and molecular simulations were employed to elucidate the corrosion inhibition mechanism. The HM-1228 inhibitor exhibited corrosion inhibition efficiency at 94.8%, and the increase in performance is attributed to the presence of di-N-ethyl groups, which enhances the electron donating ability as well as lipophilic properties.
Impact of BMI on the Survival Outcomes of non-Small Cell Lung Cancer Patients Treated with Immune Checkpoint Inhibitors: A Meta-Analysis
Authors: Zhang Tongtong , Li Shuluan , Chang Jianhua , li Chao
Published: June 2023

Objectives
ICIs have become the standard treatment for advanced NSCLC patients. Currently, PD-L1 is the most widely useful biomarker to predict ICI efficacy, but the sensitivity and specificity are limited. Therefore, the useful predictive biomarkers of ICI efficacy is urgently needed. BMI is an internationally used measure of body health. Obesity may affect ICI efficacy by changing T cell functions. This meta-analysis aimed to clarify the relationship between BMI and survival outcomes of NSCLC patients treated with ICIs.
Methods
A systematic review was conducted to identify studies that assessed the association between BMI and survival outcomes in patients treated with ICIs. OS was the primary endpoint, and PFS was the secondary endpoint. Random-effect models or fixed-effect models were utilized to combine study effects according to the Cochran Q and I2 tests.
Results
Nine studies, including 4602 NSCLC patients treated with ICIs, that met the inclusion criteria were selected for this meta-analysis. There was no significant difference in PFS (HR 0.885; 95% CI 0.777–1.009, p = 0.068) or OS (HR 0.947; 95% CI 0.789–1.137, p = 0.560) between the low BMI group and the high BMI group. However, in the subgroup analysis, compared with normal-weight patients, overweight and obese patients achieved prolonged PFS (HR 0.862; 95% CI 0.760–0.978, p = 0.021) and OS (HR 0.818; 95% CI 0.741–0.902, p＜0.0001).
Conclusion
Overweight and obese NSCLC patients tend to achieve prolonged survival time with ICI regimens. Further prospective studies are needed to strengthen the association between ICI outcomes and BMI levels.
Optimization of vertically aligned carbon nanotube beam trajectory with the help of focusing electrode in the microchannel plate
Authors: Adhikari Bishwa Chandra , Ketan Bhotkar , Patil Ravindra , Choi Eun Ha , Park Kyu Chang
Published: June 2023

The focusing electrode plays an important role to reduce the electron beam trajectory with low dispersion and high brightness. This article summarizes the importance of the vertically aligned multi-walled carbon nanotube effect with the focusing electrode. First of all, the effect of electron beam trajectory is studied with the different heights, hole sizes, and applied voltage of the focusing electrode by the opera 3D simulation. The field emission electron beam spot is captured in the microchannel plate which helps to reduce the signal noise effect and damage of CNT tips by the joule heating effect. The high-dense bright spot is optimized at the focusing electrode hole size of 2 mm, and the height of 1 mm from the gate mesh electrode at the low bias voltage of -200 V without the loss of current. The FWHM of the electron beam is calculated 0.9 mm with its opening angle of 0.90 which could be applicable in high-resolution multi-electron beam microscopy and nano-focused X-ray system technology.
The lotus NnWOX1-1、NnWOX4-3 and NnWOX5-1 promoted root formation and enhanced stresses tolerance in transgenic Arabidopsis thaliana
Authors: quan Liu , Shiting Liang , Chen Zhao , Yuyan Han , Minrong Zhao , Shuyan Li , Libao Cheng
Published: June 2023

Background: Adventitious root (AR) is an important organ in water and nutrition uptake in lotus due to degeneration of principle root. Wox is involved in regulating plant development and growth by affecting multiple genes expression in plant kingdom. In this study, three genes including NnWOX1-1、NnWOX4-3 and NnWOX5-1were isolated, and genes function was assessed in Arabidopsis plants.
Results: The full-length of the NnWOX1-1、NnWOX4-3 and NnWOX5-1 were 1038 bp, 645 bp and 558 bp in nucleotide, and encoded 362, 345 and 185 amino acid residues respectively. Phylogenetic analysis showed that Nnwox1-1 and Nnwox4-3 was classified into one group, and Nnwox5-1 and Mnwox5 showed high genetic relationship. These three genes were all induced by sucrose and IAA, and had organ-speciﬁc expression characteristic. Aside from the improvement of root growth and salt tolerance, NnWOX1-1 and NnWOX4-3 could also promote stem development in transgenic Arabidopsis. A total of 751, 594 and 541genes including nineteen, nineteen and thirteen genes related with ethylene and IAA metabolism and response were enhanced expression in NnWOX1-1、NnWOX4-3 and NnWOX5-1 transgenic plants respectively. Further analysis showed that ethylene product rates was increased, and while IAA, POD and lignin content were no significantly changed. Exogenous application of ethephon promoted ARs formtion and dramaticly increased fresh weight and dry weight of lotus seedlings.
Conclusions: NnWOX1-1、NnWOX4-3 and NnWOX5-1 was involved in root formation, stem development and stresses adaptation in transgenic Arabidopsis plants by affecting multiple genes transcriptation. Among which, the change of genes expression in ethylene metabolism and respondings probably exerted criticle role on development in Arabidopsisplant. In addition, ethylene might be an important factor to affect ARs formation in lotus seedlings.
Rapid detection of lung cancer based on serum Raman spectroscopy and a support vector machine: a case-control study
Authors: Yan Linfang , Su Huiting , Liu Jiafei , Wen Xiaozheng , Luo Huaichao , Yin Yu , Guo Xiaoqiang
Published: June 2023

Background
Early screening and detection of lung cancer is essential for the diagnosis and prognosis of the disease. In this paper, we investigated the feasibility of serum Raman spectroscopy for rapid lung cancer screening.
Methods
Raman spectra were collected from 45 patients with lung cancer, 45 with benign lung lesions, and 45 healthy volunteers. The machine learning support vector machine (SVM) method was applied to build a diagnostic algorithm. Furthermore, 15 independent individuals were sampled for external validation, including 5 lung cancer patients, 5 benign lung lesion patients, and 5 healthy controls.
Results
Its diagnostic sensitivity, specificity, and accuracy were 91.67%, 92.22%, 90.56% (lung cancer vs. healthy control), 92.22%,95.56%,93.33% (benign lung lesion vs. healthy) and 80.00%, 83.33%, 80.83% (lung cancer vs. benign lung lesion). For the independent test, our model showed that all the samples were classified correctly.
Conclusion
Therefore, this study demonstrates that the serum Raman spectroscopy analysis technique combined with the SVM algorithm has great potential for the noninvasive identification of lung cancer.
“Mortality or not mortality, that is a question …” How to treat removals in tree survival analysis of managed forests
Authors: Lech Paweł , Kamińska Agnieszka
Published: June 2023

Tree mortality is an objective and easily definable criterion for forest health and is particularly suitable for long-term and large-scale studies of forest condition. However, it is not possible to accurately determine actual tree mortality in managed forests that are subject to silvicultural and sanitary, periodic or continuous tree removal. In this case, the only way to approximate actual tree mortality is to define the range in which it occurs by determining minimum and maximum mortality thresholds. For this purpose, we performed a survival analysis and considered the removals as either censored or complete observations. The results obtained showed significant differences, indicating the importance of how removals are classified in the analysis. An attempt to determine the similarity of removed trees to alive or dead trees in terms of defoliation, severity of damage, DBH and age of the trees revealed inconsistencies between species and the year for which this analysis was also performed. Removed trees from species in good health (pine) resembled alive, while removed trees from species in poor health (spruce) resembled dead trees more. This result suggests that in managed stands of healthy species the actual mortality is closer to the minimum, while in species in poor health it is closer to the maximum mortality.
Three-Input Logic Gate Based on DNA Strand Displacement Reaction
Authors: Ma Jingjing
Published: June 2023

In this paper, three kinds of three-input logic gates are designed based on DNA strand displacement reaction, which are three-input OR logic gate, three-input AND logic gate, and three-input MAJORITY logic gate. The logic gates designed in this paper takes different DNA strands as input and fluorescence signals as output. The biochemical experimental results verify my designs. The results show that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.
Reliability and validity of the Patient Experiences Questionnaire for Interdisciplinary Treatment for Substance Dependence – Continuous Electronic Measurement (PEQ-ITSD – CEM)
Authors: Iversen Hilde Hestad , Haugum Mona , Ellingsen-Dalskau Lina Harvold , Bjertnaes Oyvind
Published: June 2023

Background
Inpatient experiences with interdisciplinary treatment for substance dependence and mental health care are measured using continuous electronic measurements in Norway. Major changes in data collection from cross-sectional surveys to continuous measurements necessitated the revalidation of the instrument. The main purpose of the present study was to determine the psychometric properties of the Patient Experiences Questionnaire for Interdisciplinary Treatment for Substance Dependence – Continuous Electronic Measurement (PEQ-ITSD – CEM). We also aimed to develop a short version of this tool, since completing the original version can be burdensome for some patients.
Methods
The study included adult inpatients (aged ≥16 years) who received substance-dependence treatment at 102 different sections in Norway during 2020–2022 (n=2,850). Levels of missing data, ceiling effects, factor structure, internal consistency and item performance were assessed. A short scale was developed based on the psychometric testing results that included item response theory analysis.
Results
The PEQ-ITSD – CEM comprised three empirically based scales with good internal consistency, reliability and validity, which cover treatment and personnel (14 items), milieu (6 items) and outcome (5 items). The results supported a seven-item short-formscale, with three items selected for the treatment and personnel scale, two items for the milieu scale and two items for the outcome scale.
Conclusions
The PEQ-ITSD – CEM can be recommended for future assessments of patient experiences with interdisciplinary treatment for substance dependence in Norway and in other countries with similar healthcare systems. This short-form scale can be applied when respondent burden is a crucial issue.
Faecal carriage and risk factors of carbapenemase-producing gram-negative bacteria resistant to third-generation cephalosporins in hospitalized and non- hospitalized patients, Kenya
Authors: Maina Anthony Karoki , Maingi John , Mutuma Caroline Kirito , Njeru John , Musyoki Abednego
Published: June 2023

The authors have requested that this preprint be removed from Research Square.
Multi-database analysis showed that genes associated with inflammatory response are important for prognosis prediction of renal clear cell carcinoma
Authors: Xiao Yonggui , Xu Danping , Jiang Chonghao , Li Hubo , Liu Jinzheng , Huili Youlong , Nie Shiwen , Cao Fenghong , Guan Xiaohai
Published: June 2023

Background
Clear cell carcinoma of the kidney is the largest subtype of kidney tumor. Inflammatory responses are involved in all stages of the tumor. The relationship between genes related to inflammatory response and renal clear cell carcinoma is expected to help the diagnosis and treatment of tumor patients.
Methods
First, we obtained all the data needed for this study free of charge from a public database. After differential analysis and COX regression, we obtained genes that were used to build the model. In addition, data from multiple databases were included in this study. To make the data from different sources comparable, we standardize all the data using the SVA package. Next, through LASSO regression, we constructed a prognostic model of genes related to inflammation (IRGM). The model contains 10 gene model signatures related to the inflammatory response (IRGMS). The data used for modeling and internal validation came from the TCGA database and the GSE29609 dataset. Clear cell renal carcinoma data from the ICGC database will be used for external validation. Tumor data from E-MTAB-1980 cohort will provide an additional external validation. The GSE40453 dataset and the GSE53757 dataset will be used to verify the differential expression of IRGMS. The immunohistochemistry of IRGMS will be queried through the HPA database. After adequate validation of IRGM, we explored the application of IRGM in greater depth by constructing nomograms, pathway enrichment analysis, immunocorrelation analysis, drug susceptibility analysis, and subtype identification.
Results
IRGM can robustly predict the prognosis of patient samples with clear cell carcinoma of the kidney from different databases. IRGMS (IGFBP3, SCNN1B, IFI16, LRRC19, GSTM3, IFI44, APOLD1, HPGD, CPA3, PROM1) is expected to become a new biomarker associated with clear cell carcinoma of the kidney. The construction of nomogram can use IRGM to predict patient survival more accurately, so as to adopt more reasonable treatment methods. Pathway enrichment analysis showed that patients in the HR group were associated with a variety of tumorigenesis biological processes. Immune-related analysis and drug susceptibility analysis suggest that patients with higher IRGM scores have more treatment options. The subtype identification results are conducive to further refinement of treatment.
Conclusion
IRGMS (IGFBP3, SCNN1B, IFI16, LRRC19, GSTM3, IFI44, APOLD1, HPGD, CPA3, PROM1) is valuable in predicting the prognosis of clear cell carcinoma of the kidney. Patients with higher IRGM scores may be better candidates for treatment with immune checkpoint inhibitors and have more chemotherapy options.
Hyperspectral image synthesis from sparse RGB data: a comparative study combining linear regression, multilayer perceptron, and clustering
Authors: Magalhães Antônio Hamilton , Yehia Hani Camille , Magalhães Hermes Aguiar
Published: June 2023

The problem of synthesizing hyperspectral images from RGB images is ill posed, with potentially infinite solutions, as it involves estimating data in a high-dimensional space, associated with hyperspectral bands, from limited information in a three-dimensional RGB space. However, under certain conditions related to lighting and physical properties of natural scenes, a feasible solution can be found. This study evaluates four methods for estimating hyperspectral data from RGB images: Ridge linear regression, Minibatch K-means followed by linear regression, a multilayer perceptron (MLP) neural network, and Minibatch K-means combined with an MLP neural network. The results of each method are compared with each other and with the NTIRE 2020 Challenge. The comparison was performed using the Mean Absolute Relative Error (MARE) and execution time. The MLP method attained the lowest MARE (0.072) but with the longest execution time (220 s). Ridge regression attained the shortest execution time (0.47 s) at the cost of a higher MARE (0.089). The best trade-off was obtained by combining Minibatch K-means clustering with MLP, which reduced the execution time by 16 times (13.8 seconds) with a slightly higher MARE (0.075) compared to MLP alone. We have also confirmed that, for the case of natural scenes, points representing pixels that are close to each other in the RGB space are also close to each other in the hyperspectral space.
Genetic basis and repeatability for desiccation resistance in Drosophila melanogaster (Diptera: Drosophilidae)
Authors: Fanara Juan Jose , Sassi Paola Lorena , Goenaga Julieta , Hasson Esteban
Published: June 2023

Dehydration is a stress factor that affects organisms in certain natural habitats, so it is to be expected that populations will develop mechanisms that maximize resistance to desiccation. Insects are an excellent model for studying the effects of dehydration as well as the mechanisms and processes that prevent the effects of water loss since the effect of desiccation is greater owing to the higher area: volume ratio than larger animals. Even though physiological and behavioral mechanisms to cope with desiccation are being understood, the genetic basis underlying the mechanisms related to variation in desiccation resistance and the context-dependent effect remain unresolved. We analyzed the genetic bases of desiccation resistance in Drosophila melanogaster and identified candidate genes that underlie trait variation. Our quantitative genetic analysis of variation in desiccation resistance revealed sexual dimorphism and extensive genetic variation. The phenotype-genotype association analyses (GWAS) identified 71 candidate genes responsible for total phenotypic variation in desiccation resistance. Half of these candidate genes were sex-specific suggesting that the genetic architecture underlying this adaptive trait differs between males and females. Moreover, the public availability of desiccation data analyzed on the same lines but in a different lab allows us to investigate the reliability and repeatability of the results obtained in independent phenotype screens. These analyses indicate a pervasive micro-environment lab-dependent effect since we did not detect overlap between our own estimates of desiccation resistance and the results obtained in another lab.
The Process of Human Creation in The View of HAMKA With The Nazhariyyat Al-Siyaq Approach (Analysis of The Book of Al-Azhar)
Authors: Affandi Yuyun , Abdillah Maljaul Abror , Asna Latifatul , Alhuwaymil Mohammed Saad
Published: June 2023

This research tries to elaborate on the interpretation of HAMKA in his book Tafsir al-Azhar (تفسير الأزهر) on the verses of the process of human creation, especially in Q.S. Al-Mu'minun/23:1-17. Most researchers seem more inclined to approach the Kauniyyah verses from the standpoint of scientific explanation, including when interpreting verses related to the process of human creation (embryology) in Q.S. Al-Mu'minun/23:1-17. If scrutinized, HAMKA’s interpretation of these is present in disputing disbelievers' rejection of the phenomena of physical resurrection (Ba'tsu al-Ajsad) on the Day of Judgment. This study is qualitative in form and was created using a literature review using the Nazhariyyat al-Siyaq approach (نظرية السياق) to see the substance of these verses from the context of their appearance in Surat al-Mu'minun while considering the similarity of their context which exist in Chapter al-Hajj and al-Ghafir. The results of this study indicate that HAMKA interprets the verses in Q.S. Al-Mu'minun/23:1-17 by dividing them into two clusters. First, verses 1-11 are about the characteristics of a believer person. Second, verses 12-17 are about the process of human creation, which ends with a warning about the day of resurrection. HAMKA combines verses 12, 13, and 14, which discuss the process of human creation, into one cluster with verses 15-17 about the day of resurrection. In the writer's opinion, through the Nazhariyyat al-Siyaq approach (theory of context), it appears that the presence of verses 12, 13, and 14 (which talk about the process of human creation) is more of an invitation to reflect on the origin of human beings, where did they come from, how did they live and where will they return? In other words, HAMKA's interpretation of verses 12, 13, and 14 has more of an eschatological nuance (i.e., belief in the existence of a physical resurrection [ba'tsu al-ajsad] on the Day of Resurrection) rather than a scientific nuance.
Predicting land use effects on flood susceptibility using machine learning and remote sensing in coastal Vietnam
Authors: Vu Van Tich , Nguyen Huu Duy , Vu Phuong Lan , Ha Minh Cuong , Bui Van Dong , Nguyen Thi Oanh , Hoang Van Hiep , Nguyen Thanh Kim Hue
Published: June 2023

Flood damage is becoming increasingly severe in the context of climate change and changes in land use. Assessing the effects of these changes on floods is important, to help decision-makers and local authorities understand the causes of worsening floods and propose appropriate measures. The objective of this study was to evaluate the effects of climate and land use change on flood susceptibility in Thua Thien Hue province, Vietnam, using machine learning techniques (support vector machine (SVM) and random forest (RF)) and remote sensing. The machine learning models used a flood inventory including 1,864 flood locations and 11 conditional factors in 2017 and 2021, as the input data. The predictive capacity of the proposed models was assessed using the area under the curve (AUC), the root mean square error (RMSE), and the mean absolute error (MAE). Both proposed models were successful, with AUC values exceeding 0.95 in predicting the effects of climate and land use change on flood susceptibility. The RF model, with AUC = 0.98, outperformed the SVM model (AUC = 0.97). The areas most susceptible to flooding increased between 2017 and 2021 due to increased built-up area.
The Fermat's last theorem from the eye of physicist
Authors: Avdyev Marat Aleksandrovich
Published: June 2023

The article is about the fact that the extraordinary beauty and conciseness of the formulation of Fermat's Last Theorem make us look for its visual solution. Let's try to consider Fermat's theorem from the eyes of physicist. Perhaps from this positions Pierre de Fermat found a solution whose main ideas would fit schematically in the fairly wide margins of the book, in a few drawings. Skeptics continue to believe that Pierre de Fermat was probably mistaken. Meanwhile, consistent application of the basic principles of physics, geometry, and engineering make us think differently.
Risk assessment in storage tanks of the oil and gas industry
Authors: Al-Rawhani N. M. , Alekhin V. N.
Published: June 2023

Aim. Accidents at oil and gas facilities are among the main causes of environmental pollution and loss of life. In the interests of solving the problem of ensuring the safety of oil and gas facilities, a review of the state of oil and gas facilities in the republic of Yemen was carried out, statistical data on accidents were analysed, defined the events that cause a fire in hazardous situations and build scenarios for the occurrence and development of fires through the study of an accident in the Aden refinery, also assessment of the mass of flammable substances entering the surrounding space as a result of fire hazardous situations, construction of fields of hazardous factors of fire for various scenarios of its development, assessment of the consequences of exposure to hazardous fire factors on people, and a base was developed for risk assessment and management.
Granitic affinity mineralization in the central portion of the Colangüil batholith. Province of San Juan, Argentina
Authors: Wetten Aníbal F.
Published: June 2023

The central portion of the Batholith of Colangüil belongs to the Frontal Range and is located in the northwest of San Juan province, Argentina. It includes different granite units of Permian in age: Romo, Conconta, and Agua Blanca. These intrude the Cerro Agua Negra Formation, an Upper Carboniferous - Asselian sedimentary unit. These units are partially covered by volcaniclastic rocks of the Choiyoi Group, lower Permian-Triassic in age. The region was characterized by mineral extractions during the last century. Metalliferous mineralization has been recognized in the higher elevation areas of the Conconta and Agua Blanca plutons, with an early paragenesis of wolframite, fluorite, niobium, and quartz, and later deposition of scheelite, in quartz gangue. The latter was observed in the Agua Blanca pluton. The tectonic of the Cisuralian Permian San Rafael phase, compressive in nature, affected mainly the Cerro Agua Negra Formation. An oriented NW-SE fault array on the aforementioned igneous and sedimentary units stands out. Two regional fracturing axes limit laterally this sector of the batholith and match the location of the mineral deposits. A greater ascent of granite basement blocks can be seen to the south of the Conconta pluton and in the surroundings of the Agua Blanca pluton, based both on the intense erosion of its sedimentary host rock and by the little development of mineralization in the Romo sector. The fluid inclusion assemblages present in the veins of the Conconta and Romo sectors are linked with saline and carbonic fluid types, typical of the tungsten deposition cycle.
NPM3 as an Unfavorable Prognostic Biomarker Involved in Oncogenic
Pathways of Lung Adenocarcinoma via MYC Translational Activation
Authors: Chen Long , Yang Demeng , Huang Fen , Xu Weicai , Luo Xiaopan , Mei Lili , He Ying
Published: June 2023

Background:

The nucleoplasmin/nucleophosmin (NPM) family was previously regarded
as a critical regulator during disease development, and its mediation in carcinogenesis has
achieved intensive attention recently. However, the clinical importance and functional mechanism
of NPM3 in lung adenocarcinoma (LUAD) have not been reported yet.

Objective:

This study aimed to investigate the role and clinical significance of NPM3 in the development
and progression of LUAD, including the underlying mechanisms.

Methods:

The expression of NPM3 in pan-cancer was analyzed via GEPIA. The effect of NPM3 on
prognosis was analyzed by the Kaplan-Meier plotter and the PrognoScan database. In vitro, cell transfection,
RT-qPCR, CCK-8 assay, and wound healing assay were employed to examine the role of
NPM3 in A549 and H1299 cells. Gene set enrichment analysis (GSEA) was performed using the R
software package to analyze the tumor hallmark pathway and KEGG pathway of NPM3. The transcription
factors of NPM3 were predicted based on the ChIP-Atlas database. Dual-luciferase reporter
assay was applied to verify the transcriptional regulatory factor of the NPM3 promoter region.

Results:

The NPM3 expression was found to be markedly higher in the LUAD tumor group than
the normal group and to be positively correlated with poor prognosis, tumor stages, and radiation
therapy. In vitro, the knockdown of NPM3 greatly inhibited the proliferation and migration of A549
and H1299 cells. Mechanistically, GSEA predicted that NPM3 activated the oncogenic pathways.
Further, the NPM3 expression was found to be positively correlated with cell cycle, DNA replication,
G2M checkpoint, HYPOXIA, MTORC1 signaling, glycolysis, and MYC targets. Besides, MYC targeted
the promoter region of NPM3 and contributed to the enhanced expression of NPM3 in LUAD.

Conclusion:

The overexpression of NPM3 is an unfavorable prognostic biomarker participating in
oncogenic pathways of LUAD via MYC translational activation and it contributes to tumor progression.
Thus, NPM3 could be a novel target for LUAD therapy.
Radiological Evaluation of Effectiveness of PCCP Fixation for Femoral Neck
Fracture: Med-term Effectiveness in a Retrospective Multicenter
Authors: Tang Wen , Wei Changbao , Dai Liansheng , Lu Dong , Meng Weichun , Zhou Zihong , Gu Sanjun , Li Haifeng , Ding Yanping
Published: June 2023

Background:

It has been reported in the literature that the complication rate of percutaneous compression plate (PCCP) is the lowest among the new internal fixators for the treatment of femoral neck fracture (FNS). However, no multicenter studies of PCCP for FNS have been reported. This study aimed to evaluate the med-term effectiveness of PCCP in a multicenter mainly through radiology.

Methods:

265 patients with FNF treated with PCCP fixation in our five hospitals between January 2011 and December 2020 were retrospectively analyzed. 140 men and 125 women; aged 19–79 (mean 51.6）years. The follow-up time was 2-5 years (mean 3.1). Radiological evaluation of the therapeutic effect was the main outcome, and the function was the secondary outcome.

Results:

One case of screw cutting out, 3 cases of screw back out, 25 cases of neck shortening, 2 cases of nonunion, 8 cases of delayed healing, and 29 cases of avascular necrosis (AVN). Bivariate correlation showed that shortening healing was correlated with age, Singh index, and Garden alignment index, poor healing was correlated with garden alignment index, and AVN was correlated with Pauwels and Garden classifications and operation timing. Further pairwise comparison analysis showed that age of > 65 and Singh index IV were dangerous factors for neck shortening, and the operation timing > 3 days, Pauwels II and III, and Garden III and IV were dangerous factors for AVN. The excellent and good rate of function in 198 patients who were readmitted for internal fixator removal or other surgery was 90.9%.

Conclusion:

PCCP for FNS has satisfactory med-term efficacy with a low complication rate. The main complication is AVN, which is prone to occur in patients with displaced Pauwels II or III FNF and operation timing > 3 days. Another main complication is shortening healing, which is prone to occur in patients with an age of > 65 and Singh index IV.
Managing Cancer Treatment in Patients with Renal Dysfunction: The Role of
Chemotherapy
Authors: Aghsaeifard Ziba , Alizadeh Reza
Published: June 2023

Malignancy is characterized by damage to several vital organs, and utilizing chemotherapy as a treatment
option can have toxic effects on healthy body tissues. Kidney function is commonly compromised by cancer and
chemotherapy. These effects can be pre-renal, intrarenal, or postrenal. Tumor lysis syndrome and electrolyte disturbances
are also common in this group of patients. Etiologies of this dysfunction are poorly understood; therefore, careful
monitoring and management of renal function are required in such cases. This narrative review aimed to highlight
some of the common renal abnormalities among patients receiving cancer and chemotherapy.
A Historical Review for City Branding: Hyper Competition, Challenges, and Improvement Opportunities
Authors: Suardi Wahdania , Nurmandi Achmad , Mutiarin Dyah , Purnomo Eko Priyo , Pribadi Ulung , Purwaningsih Titin , Misran Misran , Zulkifli Zarina , Younus Muhammad
Published: June 2023

This study aims to present a history of city branding: hyper-competition, challenges, and opportunities for improvement. The method used in this study used qualitative with a literature study approach. The findings in the study showed that in understanding the place and building city branding, there are at least three processes first through urban governance planning or infrastructure, then observation by looking at other places in the city branding. Finally, branding representation on social media is in the form of websites and tweets through news, while Instagram is through branding images from somewhere and several other media. Furthermore, City branding can be hyper-competition, showing that business competition is increasing. On the other hand, it can be a challenge and an opportunity considering that many cities have reimagined their competitive strategies by maximizing their internal potential, namely existing resources, to take opportunities and anticipate the threats faced. The contribution of this study provides an understanding of measurements in the city branding literature, helps researchers discover new studies, and can interpret the complex nature of cities. Another thing is that closing the gap between theory and practice presents a huge challenge for brands.
Shariah Review and Shariah Audit: Shariah compliance tools in Islamic banks
Authors: Yasoa' Mohd Rushdan , Wan Abdullah Wan Amalina , Endut Wan Anisah
Published: June 2023

Shariah review and Shariah audit serve as a second and third line of defense in Islamic banks. This study intends to analyse the differences between these two Shariah organs based on roles, guidelines and methodology, scope of duties, technology, independence, and reporting structure as well as officers’ qualifications. A qualitative approach is used by employing semi-structured interviews with nine (9) practitioners. Data gathered from interviews have been transcripted and analyzed using Atlas.ti. Findings reveal that a clear function of Shariah review and Shariah audit is pertinent to effectively mitigate risks. This scenario could eventually provide a stimulus to improve governance and market confidence.
Objectivity Valuation in Islamic Visual Art Characteristics
Authors: WMD Wan Samiati Andriana , Mokhtar Mumtaz , Sabri Nik Syahida , M.Hum Yulriawan Dafri
Published: June 2023

This paper discovered the potential of objectivity toward valuation based on the visual art characteristic. The study was the object of specific investigations aimed at establishing the Islamic visual arts component. The questionnaire is contributed together with twenty-one artworks that have been selected for the questionnaire analysed. The selected artworks are from painting, printmaking, sculpture, and mixed media, under the Islamic theme and exhibitions. The objectivity valuation was based on understanding the value of axiological philosophy. The benefits of this study will allow for a better understanding and appreciation of Islamic visual art that can also be applied to artistic practice.
Effect of Perceived Social Support on Emotional Intelligence of Malaysian Service Sector Employees
Authors: Samuel Rachel , Osman Idris , Lopez Gregore Pio
Published: June 2023

The goal of this study is to ascertain how emotional intelligence, made up of personal and social competence, is affected by perceived social support. The sources of perceived social support are loved ones, close friends, and significant others. Emotional intelligence enables people to control their emotional energy to support those around them. Service sector employees are targeted as they deal with the effects of the recent pandemic. PLS-SEM was used to analyse 536 responses. Personal and social competencies were impacted by perceived social support. Surprisingly, personal competency was more strongly impacted. For various other economic sectors, similar analyses can be conducted.
The effectiveness of aromatherapy combination of pepperlav (peppermint and lavender) to relieve nausea vomiting in pregnant women
Authors: Zuliyati Isti Chana , Fatmawati Annisa , Mulyaningsih Sundari
Published: June 2023

Background : Nausea and vomiting in first trimester pregnant women can cause symptoms of prenatal distress and stress which will affect a mother’s quality of life. Nausea and vomiting will also affect the nutritional intake of the mother and fetus. Nutritional needs that are not fulfilled from the beginning of pregnancy can cause fetal growth restriction which can cause short and long term complications and have a negative impact on quality of life.

Objectives : This research aims to test the combination aromatherapy product Pepperlav (Peppermint and Lavender) in pregnant women to relieve nausea and vomiting.

Methods : This study pretest-posttest control group design method with a total sample of 40 first trimester pregnant women who experienced nausea and vomiting. This research was conducted at the Midwife Independent Practice in the Bantul Region. Data collection was carried out by interviewing and filling out questionnaires that measured nausea and vomiting before and after the intervention. The questionnaire used is a valid and reliable RINVR. Intervention were carried out by administering Pepperlav Aromatherapy Combinations with formulations FIB (40:50:10), F2B (30:60:10), F3B (20:70:10) with VCO based notes that have fulfilled the physical stability, homogeneity, measurement PH, spreadability and adhesion tests, product safety tests and preference tests conducted on women who are not pregnant. Data were analyzed using the Paired t Test.

Results : Based on statistical tests with Paired t test analysis p value: 0.001, this shows that the p value <0.05, there is a significant effect on the administration of pepperlav aromatherapy in Formula 1 formulation (a combination of 40% peppermint, 50% Lavender and 10% VCO.

Conclusions : Aromatherapy combination of Pepperlav (peppermint and lavender) can relieve nausea and vomiting in pregnant women.
The effect of Hatha Yoga on pain intensity in severe primary dysmenorrhea among students: A randomized controlled trials
Authors: Haryono Ignatio Rika , Sudarman Jessica Putri , Prastowo Nawanto Agung , Lilis Lilis
Published: June 2023

Background: Yoga has been known as an alternative therapeutic modality for reducing pain. The benefits of yoga for reducing pain have been proven. Women often suffer pain due to dysmenorrhea. The effect of Yoga on dysmenorrhea pain has not been widely studied

Objectives: This study aimed to investigate the effect of hatha yoga on pain in primary dysmenorrhea (PD).

Methods: This was a randomized controlled study (RCT) involving 50 female students, 25 each in control (C) and yoga group (Y). PD was diagnosed by Working ability, Location, Intensity (Wong-Baker scale), and Days of the Pain of Dysmenorrhea (WaLIDD) questionnaire. Pain intensity was assessed by the Numeric Rating Scale (NRS). Hatha yoga training was conducted for 12 weeks. The unpaired t-test, ANOVA and Tukey post hoc, and Pearson correlation test was applied. Significance was set at p<0.05.

Results: The characteristics between groups were not different. ANOVA indicated the NRS score in control was not changed, while yoga was diminished (p=0.02). Tukey post hoc showed that the second and third NRS were lower than basal NRS (p=0.038 and 0.01, respectively). The third was also lower than the second NRS (p=0.039). The second and the third NRS in yoga were lower than in control (p=0.027 and <0.01, respectively). The second magnitude of change of NRS was significantly different from the first in yoga (1.92 ±2.4 vs. 3.09 ± 2.8, p=0.018). The magnitude of NRS changes in the first (0.06±1.1 vs. 1.92±2.4, p=0.013) and second (0.02 ± 1.6 vs. 3.09 ± 2.8, p= 0.004) in yoga was significantly greater than the control. NRS score was not correlated with age, BMI, and age of menarche.

Conclusions: Hatha yoga exercise ameliorate pain intensity in primary dysmenorrhea among female university students.
Explainable Artificial Intelligence in Quantifying Breast Cancer Factors: Saudi Arabia Context (Preprint)
Authors: Alelyani Turki , Alshammari Maha , Almuhanna Afnan , Asan Onur
Published: June 2023

UNSTRUCTURED

Breast cancer is the most common cancer in women worldwide, and early detection and accurate diagnosis are crucial for improving patient outcomes. In Saudi Arabia, it is the most prevalent cancer type among women, with a projected increase by the year 2040. In this research, we aimed to apply Explainable Artificial Intelligence (XAI) learning approaches to predict benign and malignant breast cancer using various clinical and pathological features of breast cancer patients in Saudi Arabia. Six different models were trained, and their performance was evaluated using several common metrics, including accuracy, precision, recall, F1 score, and AUC-ROC score. To improve transparency and interpretability, we applied Local Interpretable Model-Agnostic Explanations (LIME) and SHapley Additive exPlanations (SHAP) to interpret the proposed models. Our analysis reveals that the Random Forest model exhibited the highest performance metrics compared to all other models, demonstrating its proficiency in accurately predicting benign or malignant breast cancer diagnoses. The model achieved an accuracy of 0.72, along with precision, recall, F1 score, and AUC-ROC score values of 0.69, 0.77, 0.73, and 0.72, respectively. Conversely, the Support Vector Machine model demonstrated the poorest performance metrics among all models, with an accuracy of 0.59, indicating its limited ability to accurately predict breast cancer diagnoses. Moreover, the application of XAI approaches revealed notable discrepancies in the rankings of feature importance across the proposed models, highlighting the need for further investigations. These findings provide valuable insights to healthcare providers regarding the diagnosis and interpretation of machine learning results, as well as the potential integration of such technologies in healthcare practices.
Kemitraan taman bacaan masyarakat dengan lembaga kemasyarakatan dalam diseminasi informasi kesehatan
Authors: Nursari Tita , Lusiana Elnovani , Yanto Andri
Published: June 2023

Introduction. This study aims to explore strategies, stages, and understand  the partnership model applied by TBM Sahabat Pena (SP) and Karang Taruna in disseminating health information.

Research methods. This study used a qualitative approach  with a case study involving interviews, observation, and document study. With a purposive sampling, four informants and one expert were involved from the TBM SP partnership.

Data analysis. Data analysis was conducted through data reduction, data presentation, and conclusion.

Results and Discussion. The TBM SP creates strategies to establish partnerships among the parties who have a personal interest and collaboration with the TBM manager by using the existing resources. The stages conducted were identified in four stages: initiating, implementating, monitoring & learning, developing and maturing stage.

Conclusion and recommendations. All activities related to partnership need to be in line with the TBS vision and mission. The implementation stage is the most influential stage in the success and sustainability of the partnership. The active role of the TBM manager is definitely needed.
Kemampuan literasi remaja wanita di Desa Tawangrejo Kabupaten Blitar dalam menghadapi budaya fashion pada era teknologi informasi
Authors: Prajawinanti Arin , Fitria Ria
Published: June 2023

Introduction. The more information a person needs, the more active the person is in searching for information. Adolescents tend to follow fashion updates because of, their curiosity. This study aims to identify the triggers for youth information needs for fashion.

Data Collection Methods. The paper used a qualitative approach with descriptive methods.

Data Analysis. Data analysis was carried out first by reducing the data obtained through observations, interviews, and literature study.

Results and Discussion. There are five factors that encourage the process of information seeking behavior in adolescents, psychological conditions, demographics, interpersonal relationships, environment, and characteristics of information. Information seeking behavior by youth accidentally  tend to create further interests. Several obstacles appeared in search fing information, these include difficulties to find relevant information, lack of satisfaction in model of clothes, and hard to find information . However, these obstacles can be overcome by digging information through other sources and conducting searches immediately after the needs.

Conclusion. The trigger for the information needs of adolescents related to fashion is the need to support their appearance. Many adolescents see fashion a value system in the society.
Pengembangan koleksi Perpustakaan Samudra Pustaka Desa Plosorejo Kecamatan Kademangan Kabupaten Blitar
Authors: Widodo Nurman , Syahri Moch
Published: June 2023

Introduction. This study aims to describe the collection development of the Samudra Pustaka Library.. Samudra Pustaka Library is a village library that became the best village library in 2021 nationally. The completeness of the collection is one of the indicators of the success of managing the village library management.

Data Collection Methods. The method used was a qualitative descriptive with several data collection techniques including interviews, observations, and documentation studies.

Data Analysis. Data analysis was conducted by following stages of collection development developed by Evans and Saponaro

Results and Discussion. Samudra Pustaka Library currently does not have their own collection development policy Societal analysis was conducted based on user suggestions and identified community livelihoods.. Selection criteria focus on purchases, donations, and collaboration. Weeding activities are carried out by withdrawing collections deemed unreadable. Evaluation activities are carried out by taking into account user suggestions related to collections. Several identified constraints were found on the budget, collections, and human resources.

Conclusion. All collection development processes are on the right track. A collection development policy should be created immediately.