bluuebunny/crossref_metadata_2025 huggingface dataset:
Self‐assessment of oral health, dental health care and oral health‐related quality of life among Parkinson's disease patients
Authors: Barbe Anna Greta , Bock Nadine , Derman Sonja Henny Maria , Felsch Moritz , Timmermann Lars , Noack Michael Johannes
Published: May 2016

Objective

Parkinson's disease (PD) is a common condition in elderly people and can adversely affect oral health (OH). However, the subjective burden of oral symptoms on the quality of life (QoL) of patients with PD is largely unknown and needs to be better understood. The objective of this study was to explore self‐assessed dental care in patients with PD, including the ability to perform oral hygiene, self‐assessed xerostomia, drooling and dysphagia problems, and the impact on OH‐related QoL.

Materials and methods

A questionnaire was completed by 100 patients with PD in Germany recruited from PD support groups, and included self‐assessment of dental care, the Oral Health Impact Profile (OHIP‐14) score, the levodopa equivalent daily dose, the Movement Disorder Society Unified Parkinson's Disease Rating Scale‐II and the leading OH‐related symptoms.

Results

Participants experienced xerostomia (49%), drooling (70%) and dysphagia (47%) and suffered from a limited ability to perform oral hygiene (29%). The oral symptoms xerostomia, drooling and dysphagia impaired the OH‐related QoL [OHIP total score 14.6 (9.7)–16.8 (11.4) compared to 11.3 (9.9) in participants without symptoms]. In total, 91.8% of participants had their own dentist. Only 6.1% of participants with xerostomia received advice regarding management.

Conclusion

In this study, patients with PD suffered from OH‐related symptoms (xerostomia, drooling, and dysphagia) that impaired their OH‐related QoL. Participants felt that they received adequate dental health care; however, dental advice regarding management of PD‐related OH problems was often lacking.
Genome Analysis of Pseudoloma neurophilia: A Microsporidian Parasite of Zebrafish (Danio rerio)
Authors: Ndikumana Steve , Pelin Adrian , Williot Alexandre , Sanders Justin L. , Kent Michael , Corradi Nicolas
Published: May 2016

Microsporidia are highly successful parasites that infect virtually all known animal lineages, including the model Danio rerio (zebrafish). The widespread use of this aquatic model for biomedical research has resulted in an unexpected increase in infections from the microsporidium Pseudoloma neurophilia, which can lead to significant physical, behavioral, and immunological modifications, resulting in nonprotocol variation during experimental procedures. Here, we seek to obtain insights into the biology of P. neurophilia by investigating its genome content, which was obtained from only 29 nanograms of DNA using the MiSeq technology and paired‐end Illumina sequencing. We found that the genome of P. neurophilia is phylogenetically and genetically related to other fish‐microsporidians, but features unique to this intracellular parasite are also found. The small 5.25‐Mb genome assembly includes 1,139 unique open‐reading frames and an unusually high number of transposable elements for such a small genome. Investigations of intragenomic diversity also provided strong indications that the mononucleate nucleus of this species is diploid. Overall, our study provides insights into the dynamics of microsporidian genomes and a solid sequence reference to be used in future studies of host–parasite interactions using the zebrafish D. rerio and P. neurophilia as a model.
Speculative Betas
Authors: HONG HARRISON , SRAER DAVID A.
Published: May 2016

The risk and return trade‐off, the cornerstone of modern asset pricing theory, is often of the wrong sign. Our explanation is that high‐beta assets are prone to speculative overpricing. When investors disagree about the stock market's prospects, high‐beta assets are more sensitive to this aggregate disagreement, experience greater divergence of opinion about their payoffs, and are overpriced due to short‐sales constraints. When aggregate disagreement is low, the Security Market Line is upward‐sloping due to risk‐sharing. When it is high, expected returns can actually decrease with beta. We confirm our theory using a measure of disagreement about stock market earnings.
Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC–ESI-MS/MS and NMR
Authors: Hlila Malek Besbes , Mosbah Habib , Zanina Nahla , Ben Nejma Aymen , Ben Jannet Hichem , Aouni Mahjoub , Selmi Boulbaba
Published: May 2016

Objectives

This work describes the bioguided fractionation of the flower's ethyl acetate fraction of Scabiosa arenaria Forssk. (Dipsacaceae).

Methods

The identification of the pure compound isolated has been studied by mono-dimensional NMR experiments. The mixture of phenolic compounds was analysed by LC–ESI-MS/MS. The antioxidant activity has been evaluated by the 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay.

Key findings

The bioguided fractionation of the flower's ethyl acetate fraction of Scabiosa arenaria led to the isolation of a pure compound: luteolin. The mixture of three phenolic compounds was identified as: 1, 4-O-dicaffeoylquinic acid, apigenin 7-O-glucoside and luteolin-7-O-glucoside. Two of which are reported here for the first time in Scabiosa genus. Luteolin had the highest antioxidant activity with an IC50 value of 0.02 ± 0.007 mg/ml, followed by the three phenolic compounds with an IC50 value of 0.025 ± 0.008 mg/ml.

Conclusions

The results of the present work indicate that S. arenaria flower's ethyl acetate extract could be used as natural antioxidant agents in food preservation and human health.
Physical and emotional well‐being of survivors of childhood and young adult allo‐SCT – A Danish national cohort study
Authors: Jensen Josef Nathan , Gøtzsche Frederik , Heilmann Carsten , Sengeløv Henrik , Adamsen Lis , Christensen Karl Bang , Larsen Hanne Bækgaard
Published: May 2016

The aim of this investigation was to examine, within a population‐based study of a national cohort comprising Danish survivors of allo‐SCT (n = 148), the long‐term effects of allo‐SCT in children and young adults. Physical and emotional well‐being was assessed using the Short Form 36 (SF‐36) and the HADS. Allo‐SCT‐related data were obtained from the participants' medical records. The study includes 148 patients, with an 89% response rate (n = 132). For comparison purposes, norm data from Danish (1994, n = 6000), Swedish (2006, n = 285), and British (2001, n = 1792) population samples were used. Factors negatively influencing the SF‐36 subscales included female gender; TBI; stem cells derived from PB; older age at time of questioning; and living alone. Factors significantly (p < 0.05) influencing HADS were transplantation with stem cells derived from PB and being underweight at time of questioning (median values were within normal range). Overall scores of allo‐SCT patients were similar to norm data. In conclusion, this national cohort study shows that patients treated with SCT in early life (<25) and whose survival period extended beyond 10 yr (mean) from SCT, showed similar levels of anxiety, depression, and physical and emotional well‐being to those of the normal population.
Conceptualizing and Explaining Bureauphobia: Contours, Scope, and Determinants
Authors: del Pino Eloísa , Calzada Inés , Díaz‐Pulido José M.
Published: May 2016

Several studies have described a perspective among citizens that entails a negative image of public administration or civil servants that persists even after positive encounters and experiences. However, this ambivalent attitude has rarely been studied empirically. The authors refer to this attitude as “bureauphobia” and seek to enhance the existing literature through an analysis of its scope and root causes in Spain. The article analyzes two surveys conducted in 2009 and 2010, elaborating two alternative measures of bureauphobia. The results are similar regardless of the survey used and the specific operationalization of the concept: more than 20 percent of each sample exhibits a perspective that combines a negative image of public administration and satisfaction with its performance. A general attitude of distrust stands out among the variables associated with bureauphobia. Substantial regional variation is evident in the extent of the phenomenon.
Overcoming challenges in learning probability vocabulary
Authors: Groth Randall E. , Butler Jaime , Nelson Delmar
Published: May 2016

Students can struggle to understand and use terms that describe probabilities. Such struggles lead to difficulties comprehending classroom conversations. In this article, we describe some specific misunderstandings a group of students (ages 11–12) held in regard to vocabulary such as certain, likely and unlikely. We discuss our efforts to help the students use such terms appropriately. In particular, we show how engaging students in a game requiring the use of the terms helped them begin to develop their vocabulary more fully. We also explain how a probability ladder visual organizer helped students begin to organize their thinking about the meanings of terms relative to one another.
Draft Genome Sequence of Bacillus subtilis subsp.
natto
Strain CGMCC 2108, a High Producer of Poly-γ-Glutamic Acid
Authors: Tan Siyuan , Meng Yonghong , Su Anping , Zhang Chen , Ren Yuanyuan
Published: May 2016

Here, we report the 4.1-Mb draft genome sequence of
Bacillus subtilis
subsp.
natto
strain CGMCC 2108, a high producer of poly-γ-glutamic acid (γ-PGA). This sequence will provide further help for the biosynthesis of γ-PGA and will greatly facilitate research efforts in metabolic engineering of
B. subtilis
subsp.
natto
strain CGMCC 2108.
Draft Genome Sequence of Aeromonas hydrophila TN97-08
Authors: Tekedar Hasan C. , Kumru Salih , Karsi Attila , Waldbieser Geoffrey C. , Sonstegard Tad , Schroeder Steven G. , Liles Mark R. , Griffin Matt J. , Lawrence Mark L.
Published: May 2016

Aeromonas hydrophila
is an opportunistic pathogen residing in freshwater environments that causes infection in fish and mammals. Here, we report the draft genome sequence of
A. hydrophila
strain TN97-08 isolated from a diseased bluegill (
Lepomis macrochirus
) in 1997.
Achieving perspective in work and leisure
Authors: Fox Richard
Published: May 2016

With a passion for beautiful landscapes, Richard Fox balances his working life as a diagnostic veterinary histopathologist with photography
Towards Tunable Consensus Clustering for Studying Functional Brain Connectivity During Affective Processing
Authors: Liu Chao , Abu-Jamous Basel , Brattico Elvira , Nandi Asoke K.
Published: May 2016

In the past decades, neuroimaging of humans has gained a position of status within neuroscience, and data-driven approaches and functional connectivity analyses of functional magnetic resonance imaging (fMRI) data are increasingly favored to depict the complex architecture of human brains. However, the reliability of these findings is jeopardized by too many analysis methods and sometimes too few samples used, which leads to discord among researchers. We propose a tunable consensus clustering paradigm that aims at overcoming the clustering methods selection problem as well as reliability issues in neuroimaging by means of first applying several analysis methods (three in this study) on multiple datasets and then integrating the clustering results. To validate the method, we applied it to a complex fMRI experiment involving affective processing of hundreds of music clips. We found that brain structures related to visual, reward, and auditory processing have intrinsic spatial patterns of coherent neuroactivity during affective processing. The comparisons between the results obtained from our method and those from each individual clustering algorithm demonstrate that our paradigm has notable advantages over traditional single clustering algorithms in being able to evidence robust connectivity patterns even with complex neuroimaging data involving a variety of stimuli and affective evaluations of them. The consensus clustering method is implemented in the R package “UNCLES” available on http://cran.r-project.org/web/packages/UNCLES/index.html .
Permutability graphs of subgroups of some finite non-abelian groups
Authors: Rajkumar R. , Devi P.
Published: May 2016

In this paper, we study the structure of the permutability graphs of subgroups, and the permutability graphs of non-normal subgroups of the following groups: the dihedral groups [Formula: see text], the generalized quaternion groups [Formula: see text], the quasi-dihedral groups [Formula: see text] and the modular groups [Formula: see text]. Further, we investigate the number of edges, degrees of the vertices, independence number, dominating number, clique number, chromatic number, weakly perfectness, Eulerianness, Hamiltonicity of these graphs.
Hemoglobin Value Is the Most Important Factor in the Development of Hand-Foot Syndrome under the Capecitabine Regimen
Authors: Naito Masahito , Yamamoto Tomoya , Hara Shinsuke , Shimamoto Chikao , Miwa Yoshihiro
Published: May 2016

Background: Hand-foot syndrome (HFS) is a common side effect that has a high occurrence rate with capecitabine (Cape) chemotherapy. However, little is known about the risk factors of developing HFS under the Cape regimen. Our aim was to examine these risk factors. Methods: A univariate analysis was used to determine the risk factors associated with developing HFS, and we calculated the effect sizes between the patients who developed HFS compared to those who did not. Results: Of the 52 patients enrolled in our research, 24 (46.2%) developed HFS. This group was significantly associated with hemoglobin (Hb) values (p < 0.001), and the effect size (1.21) was more than moderate. The receiver operating characteristic curve analysis confirmed 12 mg/dl Hb as the best diagnostic cut-off value for developing HFS. The sensitivity and specificity were 75.5 and 88.2%, respectively. Patients who had Hb values of 12 or below who developed HFS had longer median times without HFS compared to patients with high Hb values (115 vs. 75 days, p = 0.30, hazard ratio = 1.42, 95% CI 0.73-2.76) and a greater area under the Kaplan-Meier curves (p < 0.05). Conclusion: This research suggests that the Hb value is an important factor for developing HFS.
Порушення процесів вільнорадикального окиснення і антиоксидантного захисту в печінці при експериментальному алергічному альвеоліті та їх корекція тіотриазоліном
Authors: Пасічник М. А
Published: May 2016

ПОРУШЕННЯ ПРОЦЕСІВ ВІЛЬНОРАДИКАЛЬНОГО ОКИСНЕННЯ І АНТИОКСИДАНТНОГО ЗАХИСТУ В ПЕЧІНЦІ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ АЛЕРГІЧНОМУ АЛЬВЕОЛІТІ ТА ЇХ КОРЕКЦІЯ ТІОТРИАЗОЛІНОМ - У роботі показано, що експериментальний алергічний альвеоліт характеризується зростанням вмісту продуктів ліпопероксидаціі (дієнових кон’югатів і малонового діальдегіду) у всі періоди дослідження та активності ферментів супероксиддисмутази (СОД), каталази (КТ) і пероксидази (ПО) на 14 добу експерименту і суттєве зниження показників СОД, КТ і ПО на 34 і 44 доби цього модельного процесу захворювання та корегуючий вплив тіотриазоліну на дані показники.
НАРУШЕНИЕ ПРОЦЕССОВ СВОБОДНОРАДИКАЛЬНОГО ОКИСЛЕНИЯ И АНТИОКСИДАНТНОЙ ЗАЩИТЫ В ПЕЧЕНИ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ АЛЛЕРГИЧЕСКОМ АЛЬВЕОЛИТЕ И КОРРЕКЦИЯ ИХТИОТРИАЗОЛИНОМ - В работе показано, что экспериментальный аллергический альвеолит характеризуется возростанием содержания продуктов липопероксидации (диеновых коньюгатов и малонового диальдегида) в печени во все периоды исследования и активности ферментов су- пероксиддисмутазы (СОД), каталазы (КТ) и пероксидазы (ПО), особенно на 14 сутки эксперимента и существенное снижение показателей СОД, КТ и ПО на 34 и 44 сутки этого модельного процесса заболевания и корригирующее влияние тио- триазолина на эти показатели.
DISTRUBANCES OF THE PROCESSES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN LIVER AT EXPERIMENTAL ALLERGIC ALVEOLITIS AND THEIR CORRECTION WITH THIOTRIAZOLIN - The paper shows that experimental allergic alveolitis is characterized by increase of content of lipid peroxidation products (dienic conjugates and malonic dialdehyde) in all periods of study and enzyme activity of superoxide dismutase (SOD), catalase (CT) and peroxidase (PO) on the 14th day of the experiment and significant decrease of SOD, CT and PO on 34th and 44th days of this model process of disease and corrective influence of thiotriazolin on these indicators.
Ключові слова: пероксидне окиснення ліпідів, антиоксидантна система, тіотриазолін.
Ключевые слова: пероксидное окисление липидов, антиоксидантная система, тиотриазолин.
Key words: peroxidase oxidation of iipids, antioxidant system, thiotriazoiin.
ОСОБЛИВОСТІ ГОСТРОЇ ЗАКРИТОЇ ЧЕРЕПНО-МОЗКОВОЇ ТРАВМИ, ЗУМОВЛЕНОЇ ВИБУХОВОЮ ХВИЛЕЮ, В УЧАСНИКІВ БОЙОВИХ ДІЙ НА СХОДІ УКРАЇНИ
Authors: Кас Ю. В. , Коршняк В. О. , Поліщук В. Т.
Published: May 2016

Обстежено та вивчено неврологічний статус та стан вегетативної нервової системи у 39 хворих в гострому періоді закритої черепно-мозкової травми, які перебували на стаціонарному лікуванні в неврологічному відділені військово-медичного госпіталю північного регіону. Виявлено особливості в неврологічному статусі цієї групи хворих на відміну від побутових травм. Показано, що черепно-мозкова травма, яка зумовлена вибуховою хвилею, перебігає значно тяжче, ніж інша травма, одержана в мирний час.
ОЦІНКА ЕФЕКТИВНОСТІ КОМПЛЕКСНОЇ КОРЕКЦІЇ УРАЖЕННЯ ПЕЧІНКИ ПРИ ЕКСПЕРИМЕНТАЛЬНІЙ ПОЛІТРАВМІ
Authors: Корда М. М. , Кулянда О. О. , Габрусєв В. Ю.
Published: May 2016

Метою статті стало оцінити ефективність запропонованої комплексної корекції ураження печінки при експериментальній політравмі у щурів за допомогою прогностичного коефіцієнта К із врахуванням зміни основних маркерів ураження печінки, а саме: АлАТ, АсАТ та лужної фосфатази. Показано, що запропонована математична модель дає можливість оцінити ефективність методу медикаментозної корекції у певний період травматичної хвороби.
ЕФЕКТИВНІСТЬ КОРЕКЦІЇ КИСНЕВОГО ДИСБАЛАНСУ В ЩУРІВ ІЗ ГОСТРИМ РЕСПІРАТОРНИМ ДИСТРЕС-СИНДРОМОМ
Authors: Савчук С. О.
Published: May 2016

У  статті  наведено  результати  впливу  інсуфляції  киснем, похідного  ксантину  –  солі  3-(8-бромо-1,3-диметил-2,6-діоксо-2,3-дигідро-1Н-пурин-7(6Н)-іл)пропаноату (субстанції “КД-234”) та  реамберину  на  показники  поглинання  кисню  та  сатурації венозної  крові  на  фоні  експериментального  гострого  респіраторного  дистрес-синдрому.  Встановлено,  що  під  впливом експериментального ГРДС у щурів, незалежно від стійкості до гіпоксії,  показник  поглинання  кисню  достовірно  збільшується, сатурація кисню венозної крові – знижується, порівняно з контрольною групою, причому у середньостійких до гіпоксії тварин більше зростає ППО2 та меншою мірою знижується SvO2, ніж у низькостійких до гіпоксії тварин. Застосування з корегувальною метою  інсуфляції  киснем,  субстанції  “КД-234”  та  реамберину супроводжується зниженням ППО2 та підвищенням SvO2, проте найдієвішим засобом у тварин з ГРДС і різною стійкістю до гіпоксії виступає субстанція “КД-234”.
ВМІСТ МАРКЕРІВ ЗАПАЛЕННЯ У ХВОРИХ НА ІШЕМІЧНУ ХВОРОБУ СЕРЦЯ ЗАЛЕЖНО ВІД ГЕНОТИПУ ЗА ε2/ε3/ε4-ПОЛІМОРФІЗМОМ ГЕНА АПОЛІПОПРОТЕЇНУ Е ТА МАСИ ТІЛА
Authors: Л. Н. Приступа Л. Н. Приступа Л. Н. Приступа , Псарьова О. В.
Published: May 2016

ВМІСТ МАРКЕРІВ ЗАПАЛЕННЯ У ХВОРИХ НА ІШЕМІЧНУ ХВОРОБУ СЕРЦЯ ЗАЛЕЖНО ВІД ГЕНОТИПУ ЗА ε2/ε3/ε4-ПОЛІМОРФІЗМОМ ГЕНА ПОЛІПОПРОТЕЇНУ Е ТА МАСИ ТІЛА

У статті досліджено вміст маркерів запалення у пацієнтів із ішемічною хворобою серця залежно від генотипу за ε2/ε3/ε4 поліморфізмом гена аполіпопротеїну е та маси тіла. Встановлено, що ризик виникнення Іхс у хворих із ε3/ε3-генотипом та артеріальною гіпертензією був у 2,52 раза вищий, порівняно з носіями ε3/ε4+ε4/ε4-генотипів, та у 2,14 раза більший у носіїв ε3-алеля порівняно із носіями ε4-алеля. Досліджено, що носії ε3/ε3 та ε3/ε4+ε4/ε4 генотипів за наявності ожиріння мають вищі показники срб, Іл-6, порівняно з хворими із нормальною
масою тіла, що свідчить про прогресування атеросклерозу.
ОСОБЛИВОСТІ ФОРМУВАННЯ ФЕТОПЛАЦЕНТАРНОЇ НЕДОСТАТНОСТІ У ЖІНОК ІЗ ВАРИКОЗНОЮ ХВОРОБОЮ
Authors: Корнієць Н. Г. , Кравцова Ю. А.
Published: May 2016

Плацентарна  недостатність  є  важливою проблемою сучасної перинатології.  Перинатальна  захворюваність  та  смертність  у жінок групи високого ризику сягає 60 %. Метою при проведенні проспективного  дослідження  було  вивчення  основних  ланок формування фетоплацентарної недостатності у жінок із варикозною хворобою на підставі аналізу судинно-тромбоцитарної та коагуляційної ланок системи гемостазу, рівня естріолу в сироватці крові, ультразвукового дослідження плодо-плацентарного кровотоку  та  зіставлення  з  ускладненнями пологів та станом новонароджених
Abner de Burgos and the Transfer of Philosophical Knowledge between Judaism and Christianity
Authors: Sadik Shalom
Published: May 2016

Abner de Burgos (Alfonso de Valladolid, ca. 1265–1347) was perhaps the most important philosopher in the stream of Jewish-Spanish apostates in the fourteenth and fifteenth centuries. In the first part of his intellectual career, Abner was an Aristotelian Jewish philosopher. However, around the age of sixty, he became a Neo-Platonic Christian and devoted the rest of his life to trying to convert Jews to Christianity. As a philosopher who spent more than fifty years of his life as a Jew, and more than twenty-five years as a Christian, we may expect to find that Abner played a major role in the transfer of philosophical knowledge between the two religions. Here, we will see that the reality is in fact different. Abner’s familiarity with philosophical material was almost entirely limited to parts of the Spanish-Jewish curriculum. His philosophical influence was almost entirely limited to Spanish Jews, and it is only through these Jews that he had any kind of influence upon Christians in general and Western philosophers in particular.
New genera, species and records of Maeridae from Australian Waters:
Austromaera, Ceradocus, Glossomaera, Hamimaera, Huonella gen. nov.,
 Linguimaera and Maeraceterus gen. nov. (Crustacea: Amphipoda)
Authors: HUGHES LAUREN E.
Published: May 2016

Thirty species of Maeridae are reported for Australian waters including the description of two new genera and nine new species. The new genus Huonella from southern Tasmanian seamounts is distinguished among the maerids by characters on the uropod 3, including elongation of both rami, inner ramus half the length of the outer ramus and outer ramus two articulate. The new genus Maeraceterus is establish for two new species, M. bramblensis from Western Australia and M. taaroa from Norfolk Island, which have a near transverse gnathopod 1 propodus palm and symmetrical male gnathopod 2. The new species Ceradocus baudini, Hamimaera thijsseni, Linguimaera boeckoides, L. daveyi, L. everardensis and L. mere are described here in. Additional distribution records are provided for eleven known Ceradocus and seven known Linguimaera, as well as three known maerids Austromaera mastersii (Haswell, 1879a), Glossomaera octodens (Sivaprakasam, 1969) and Hamimaera hamigera (Haswell, 1879b). Collections reported on here include material from Australia; Cocos (Keeling) and Christmas Islands, Indian Ocean; the Torres Strait; Papua New Guinea, Bismarck Sea and Norfolk Island, South Pacific. Keys to Ceradocus and Linguimaera sensu lato species in Australian waters are provided.
Determination of Polycyclic Aromatic Hydrocarbons in the Presence of Humic Acid in water
Authors: Yang Ruifang , Zhao Nanjing , Xiao Xue , Yu Shaohui , Liu Jianguo , Liu Wenqing
Published: May 2016

The presence of humic acid (HA) makes it extremely difficult to determine and quantify accurately polycyclic aromatic hydrocarbons (PAHs) in aquatic environment because of their complex and strong interaction. To solve this problem, a new method was developed in this work through the combination of PARAFAC and fluorescence spectroscopy, which mainly includes: (1) the fluorescence quantum yield acquisition of PAHs with and without HA by PARAFAC; (2) the  concentration score correction of PAHs in validation and test sets using the fluorescence quantum yields; and (3) the prediction of PAHs concentration in the validation and test sets in the presence of HA by corrected concentration. Using this method, the PAHs concentration on the level of µg L−1 in the test samples with HA of 2.5 mg/L and 5.0 mg/L can be successfully predicted with the root mean square error below 0.15 µg L−1, relative error of prediction below 4% for validation samples, recoveries of each PAH between 82.5% and 102.6% for test samples.
Using Pyridinium Styryl Dyes as the Standards of Time-Resolved Instrument Response
Authors: Li Lei , Chang Mengfang , Yi Hua , Jia Menghui , Cao Xiaodan , Zhou Zhongneng , Zhang Sanjun , Pan Haifeng , Shih Chun-Wei , Jimenez Ralph , Xu Jianhua
Published: May 2016

In this paper, two pyridinium styryl dyes, [2-(4-dimethylamino-phenyl)-vinyl]-1-methylpyridinium iodide (DASPMI), were synthesized and characterized by steady state fluorescence spectroscopy as well as picosecond and femtosecond time-resolved fluorescence spectroscopies. Both dyes exhibit large Stokes shifts and fluorescence decays equivalent to the instrument response function (IRF) standards employed in time-correlated single-photon counting. Due to their styryl and pyridinium moieties, DASPMIs have higher peak fluorescence intensity and shorter excited-state lifetimes than iodide ion-quenched fluorophores. The fluorescence lifetimes of o-DASPMI and p-DASPMI were measured to be 6.6 ps and 12.4 ps, respectively. The fluorescence transients of these DASPMIs were used as the IRFs for iterative reconvolution fitting of the time-resolved fluorescence decay profiles of Rhodamine B (RhB), sulforhodamine B (SRB), and the SRB-SRB2m RNA aptamer complex. The quality of the fits employing the DASPMI-derived IRFs are consistently equivalent to those employing IRFs obtained from light scattering. These results indicate that DASPMI-derived IRFs may be suited for a broad range of applications in time-resolved spectroscopy and fluorescence lifetime imaging microscopy (FLIM), especially in the visible emission range.
Narcissistic Reactions to Subordinate Role Assignment
Authors: Benson Alex J. , Jordan Christian H. , Christie Amy M.
Published: May 2016

Narcissists aspire to be leaders and consequently may react negatively to being assigned a subordinate role, even though such roles may be integral to group functioning. In the first three studies, participants were assigned to a low status role (i.e., “employee”), high status role (i.e., “project manager”), or (in Studies 2 and 3) control condition. More narcissistic participants were less satisfied and discredited the role assignment more in the employee condition than in the project manager condition. Furthermore, more narcissistic participants displayed greater self-interest in the employee condition, relative to the project manager condition (Study 2), and less willingness to engage in behaviors to benefit the group in the employee condition, relative to the project manager and control conditions (Study 3). In Study 4, these findings were replicated in sports teams. Although there is nothing inherently negative about subordinate roles, narcissists perceive them negatively and react poorly to occupying them.
Prosocial Conformity
Authors: Nook Erik C. , Ong Desmond C. , Morelli Sylvia A. , Mitchell Jason P. , Zaki Jamil
Published: May 2016

Generosity is contagious: People imitate others’ prosocial behaviors. However, research on such prosocial conformity focuses on cases in which people merely reproduce others’ positive actions. Hence, we know little about the breadth of prosocial conformity. Can prosocial conformity cross behavior types or even jump from behavior to affect? Five studies address these questions. In Studies 1 to 3, participants decided how much to donate to charities before learning that others donated generously or stingily. Participants who observed generous donations donated more than those who observed stingy donations (Studies 1 and 2). Crucially, this generalized across behaviors: Participants who observed generous donations later wrote more supportive notes to another participant (Study 3). In Studies 4 and 5, participants observed empathic or non-empathic group responses to vignettes. Group empathy ratings not only shifted participants’ own empathic feelings (Study 4), but they also influenced participants’ donations to a homeless shelter (Study 5). These findings reveal the remarkable breadth of prosocial conformity.
Integrating the normative with the positive dimension of the new science for cities: A geodesign-based framework for Cellular Automata modeling
Authors: Kong Hui , Sui Daniel Z
Published: May 2016

Cellular Automata (CA) models are powerful simulation tools to study complex urban systems. Although there has been considerable amount of CA-based modeling work reported in the literature, few have been used as actual planning or policy making tools. The goal of this research aims to address the problem of “unapplicable CA models” by combining CA models with the framework of geodesign. Inspired by Batty's new science of cities, we put forward a geodesign-based framework for CA modeling to integrate the positive and normative dimension of the new science of cities as envisioned by Batty. Instead of merely applying CA models to positive urban studies, which typically requires more accurate predictions, we advocate the integration of positive (i.e. urban simulation) and normative (i.e. design) city science via the application of CA modeling to geodesign. By linking CA simulation with the geodesign framework, a geodesign-based CA model is developed and six urban design scenarios are integrated into the model, to test the urban growth impacts of these scenarios and generate a new design scenario accordingly. Using a case study of urban growth in Changping District, Beijing, we demonstrate that the normative and the positive dimension of Batty's new science for cities can be integrated. Geodesign, as a new conceptual framework, is helpful for streamlining the CA modelling process to evaluate different design scenarios and design new scenarios. In return, CA models could also contribute to the geodesign process by offering a tool for simulating and evaluating impacts of different design scenarios on urban growth.
Medial gastrocnemius vein aneurysm development after compressive trauma in the knee
Authors: De Santis Francesco , Candia Silvia , Scialpi Renzo , Piccinin Alfredo , Bruni Antonio , Morettini Giuseppe , Loreni Giorgio
Published: May 2016

Objectives

Venous aneurysms are uncommon. They can involve both superficial and deep venous systems. We hereby present a unique case of gastrocnemius venous aneurysm developed after compressive knee trauma.

Report

A large venous aneurysm in the left popliteal fossa was detected by chance in a 44-year-old woman one month after a compressive trauma to the posterior surface of the knee. Magnetic resonance-imaging of the same knee had documented normal venous anatomy one year earlier. The venous aneurysm involved the medial gastrocnemius vein near its confluence in the popliteal vein and was surgically resected. Histopathology evidenced a true venous aneurysm. The patient was discharged under oral anticoagulation for three months. At one year follow-up, neither complications nor new venous aneurysm development was detected.

Conclusions

An accurate evaluation of the venous system is always mandatory after limb traumas which may lead to post-traumatic venous pseudo-aneurysms, as well as more rarely, true venous aneurysms in the lower extremities.
Cluster headache: When to worry? Two case reports
Authors: Bellamio Matteo , Anglani Mariagiulia , Mainardi Federico , Zanchin Giorgio , Maggioni Ferdinando
Published: May 2016

Background

The clinical criteria for cluster headache (CH) are included in Chapter 3 of the International Classification of Headache Disorders, 3rd beta edition (ICHD-III). CH may sometimes be secondary to other pathologies.

Case reports

We report two patients in whom the clinical features of CH initially fulfilled the ICHD-III criteria, but who later presented some radical modifications in headache natural history as a result of a secondary pathology. The first case of CH was secondary to a pontine cavernous angioma and the second to a cerebral venous thrombosis.

Conclusion

We highlight the importance of clinical modifications of CH that could suggest clinical investigations should be performed or repeated to exclude a secondary pathology in a previously diagnosed cluster headache. Some of the pathological mechanisms of CH and brain lesions are discussed.
‘A world with universal literacy’
Authors: Bradley Fiona
Published: May 2016

In September 2015, after more than three years of negotiations and intense involvement from many stakeholders, including the International Federation of Library Associations and Institutions (IFLA), the Member States of the United Nations adopted the post-2015 Development Agenda to succeed the Millennium Development Goals, Transforming Our World: The 2030 Agenda for Sustainable Development. This paper outlines and reflects on the key steps in IFLA’s campaign and the importance of coalitions and national advocacy to realise the inclusion of access to information, universal literacy, public access to information and communication technology, and cultural heritage in the UN 2030 Agenda.
A Randomized Controlled Trial With Mean 16-Year Follow-up Comparing Hamstring and Patellar Tendon Autografts in Anterior Cruciate Ligament Reconstruction
Authors: Björnsson Haukur , Samuelsson Kristian , Sundemo David , Desai Neel , Sernert Ninni , Rostgård-Christensen Lars , Karlsson Jón , Kartus Jüri
Published: May 2016

Background:

There is no consensus in the current literature on which surgical options render the best long-term results after anterior cruciate ligament (ACL) reconstruction in terms of clinical outcomes and the development of radiographic osteoarthritis (OA).

Purpose:

To investigate the long-term clinical and radiographic results after ACL reconstruction using either a patellar tendon (PT) autograft or a hamstring tendon (HT) autograft.

Study Design:

Randomized controlled trial; Level of evidence, 2.

Methods:

This multicenter study was based on 2 previous randomized cohorts consisting of 193 patients who underwent unilateral primary ACL reconstruction using either a PT autograft or an HT autograft. The index surgical procedure was performed between September 1995 and January 2000. Clinical assessments, including knee laxity measurements, functional outcomes, patient-reported outcomes, and bilateral standing radiographs, were performed at the final follow-up examination.

Results:

At the long-term follow-up, 147 (76%) patients were examined: 61 in the PT group and 86 in the HT group. The mean (±SD) follow-up time was 191.9 ±15.1 months for the HT group and 202.6 ± 10.4 months for the PT group. Knee laxity measurements revealed significantly more patients with a normal pivot-shift test finding in the HT group compared with the PT group (71% vs 51%, respectively; P = .048); however, no significant differences were found in terms of the manual Lachman test or the KT-1000 arthrometer manual maximum test. The patients in the PT group had significantly more difficulty knee walking ( P = .049). There were no significant differences between the study groups in terms of patient-reported outcomes or range of motion in the reconstructed knee. In both groups, significantly more signs of radiographic OA were found in the reconstructed knee than in the contralateral healthy knee. However, there were no significant differences between the groups in terms of radiographic OA.

Conclusion:

Only minor and mostly insignificant differences were found between the PT and HT autograft groups in this long-term randomized controlled trial. In both groups, significantly more signs of radiographic OA were found in the reconstructed knee than in the contralateral knee.
Beyond Advocacy: Mapping the Contours of Victim Work
Authors: Globokar Julie L. , Erez Edna , Gregory Carol R.
Published: May 2016

In contrast to works on victim advocacy in specific organizational contexts, this article introduces the term “victim work” to capture the vast array of victim-related roles and tasks that have proliferated in recent decades. Data are derived from in-depth interviews with 30 “victim workers” in public and private agencies in two Midwestern states. The interviews revealed diverse work experiences that spanned hotlines, crisis response, legal proceedings, and postconviction support. Three themes emerged that characterize “victim work”: flexibility, emotions, and the challenge of “fit”—the multifaceted difficulties of interacting with victims and agents of the justice system. Based on the findings, we offer a revised model of criminal justice vis-à-vis victims and implications for practice and future research.
Decoupled three-dimensional entry trajectory planning based on maneuver coefficient
Authors: Liang Zixuan , Ren Zhang , Li Qingdong , Chen Jian
Published: May 2016

A rapid and decoupled three-degree-of-freedom trajectory planning approach is presented for maneuvering entry vehicles. A maneuver coefficient is defined to describe the lateral motion of a three-degree-of-freedom trajectory so that the designs for the longitudinal and lateral trajectories are decoupled. The longitudinal drag profile is planned according to the flight range that considers the maneuver coefficient. The lateral trajectory is controlled by an adjustable heading error corridor to achieve the required maneuver coefficient. The three-degree-of-freedom trajectory is finally generated based on the drag profile and the adjustable corridor. The trajectory planning algorithm is tested on two entry vehicles. Results indicate that this algorithm is capable of planning three-degree-of-freedom trajectories for nominal and maneuvering missions. The feasible region of the maneuver coefficient is investigated for each vehicle. The wide region demonstrates that the proposed planning algorithm is applicable and insensitive to estimation errors of the maneuver coefficient.
Environmental evolution and mid–late Holocene climate events in the Valencia lagoon (Mediterranean coast of Spain)
Authors: Carmona Pilar , Ruiz-Pérez José-Miguel , Blázquez Ana-María , López-Belzunce María , Riera Santiago , Orengo Héctor
Published: May 2016

Integration of geomorphological, stratigraphic, malacological, sedimentological and micropalaeontological techniques and 14C dating allows us to characterise the processes and evolution of the coastal barrier–lagoon system of Valencia (Spain), from the middle Holocene to the historical epoch, as well as the responses to global climate events. Four stages are recognised. Phase 1: around 8240 ± 80 cal. yr BP, a brackish lagoon of moderate energy and in restricted environment was formed, with an energy peak that could correspond to the maximum Holocene marine transgression. Dating (8240 ± 80 cal. yr BP) carried out in peat corresponds to a cold cycle and low water levels in inland lakes of the western Mediterranean. Phase 2: from 6450 cal. yr BP to 3710 ± 130 cal. yr BP, a lagoon remained, in restricted environment and connected with the sea, but with a notable energy decrease and recurrent saturation processes similar to those described in other Mediterranean continental lakes. This phase is contemporaneous with a period of increase in the aridity trend and global cold cycles. Phase 3: from 3710 ± 130 cal. yr BP, a brackish lagoon without marine connection was formed. Towards 820 ± 90 cal. yr BP, a shift to a totally isolated lagoon environment took place (changing from brackish lagoon to freshwater). This process is coeval with a palaeohydrological phase of high flooding frequency in the river flood plains of Spain and Southern France. Phase 4: freshwater lagoon environment becomes a widespread flood plain. During a phase of high frequency and magnitude of floods (‘Little Ice Age’), the flood plain is formed on the top level of the sequence. Phases and processes recorded in sedimentation could be placed in relation with global mid-to-late Holocene events.
Exploratory Studies With BT-11
Authors: Bissel Philippe , Boes Katie , Hinckley Jonathan , Jortner Bernard S. , Magnin-Bissel Geraldine , Werre Stephen R. , Ehrich Marion , Carbo Adria , Philipson Casandra , Hontecillas Raquel , Philipson Noah , Gandour Richard D. , Bassaganya-Riera Josep
Published: May 2016

Lanthionine synthetase cyclase-like receptor 2 (LANCL2) is a novel therapeutic target for Crohn’s disease (CD). BT-11 is a small molecule that binds LANCL2, is orally active, and has demonstrated therapeutic efficacy in 3 validated mouse models of colitis at doses as low as 8 mg/kg/d. Exploratory experiments evaluated BT-11 in male Harlan Sprague Dawley rats with a single oral dose of 500 mg/kg and 80 mg/kg/d for 14 days (n = 10 rats dosed/group). Treated and control rats were observed for behavioral detriments, and blood and tissues were collected for clinical pathology and histopathological examination. A functional observational battery demonstrated no differences between treated and control groups over multiple times of observation for quantal, categorical, and continuous end points, including posture, in cage activity, approach, response to touch, weight, grip strength, body temperature, and time on a rotarod. Histopathological examination of the brain, kidney, liver, adrenal gland, testes, stomach, small and large intestines, duodenum, pancreas, heart, lungs, spleen, thymus, and rib found no significant differences between the groups. Plasma enzymes associated with liver function were transiently elevated 2 to 4 days after the 500 mg/kg single dose but returned to normal values by 8 days and were not observed at any time in rats given 80 mg/kg/d for 14 days. One hour after oral administration of a single dose of 80 mg/kg, BT-11 had a maximal concentration of 21 ng/mL; the half-life was 3 hours. These experimental results demonstrated that BT-11 is well tolerated in rats, and, with further testing, may hold promise as an orally active therapeutic for CD.
Experimental and numerical analysis of sandwich panels with hybrid core
Authors: Studziński Robert , Pozorski Zbigniew
Published: May 2016

The paper presents the experimental and numerical studies of sandwich panels with a hybrid core. The sandwich panel consists of external steel facings and a core, which is made of polyurethane foam or mineral wool or a combination of those two materials. The polyurethane foam material has a low weight and high thermal insulation properties, while the mineral wool material can provide high acoustic insulation and excellent fire resistance. Various proportions of the core materials are taken into account. It is assumed that a proper combination can provide the benefits of both materials. The structural behavior of a sandwich structure with a hybrid core is observed during laboratory tests. The failure mechanism is investigated in a four-point bending test. The material parameters of the core and facings are determined in standardized tests. The obtained parameters are used for FE simulations of the four-point bending tests. The criteria of damage initiation and propagation are defined in the interface layer of the numerical model. A satisfactory correlation between laboratory tests and numerical results is reported. Additionally, the sensitivity analysis of the numerical model response to the variation of the parameters of the interface is presented.
Nonlinear thermo-mechanical dynamic analysis and vibration of higher order shear deformable piezoelectric functionally graded material sandwich plates resting on elastic foundations
Authors: Dinh Duc Nguyen , Hong Cong Pham
Published: May 2016

Used the Reddy's higher-order shear deformation plate theory, the nonlinear dynamic analysis and vibration of imperfect functionally graded sandwich plates in thermal environment with piezoelectric actuators (PFGM) on elastic foundations subjected to a combination of electrical, damping loadings and temperature are investigated in this article. One of the salient features of this work is the consideration of temperature on the piezoelectric layer, and the material properties of the PFGM sandwich plates are assumed to be temperature-dependent. The governing equations are established based on the stress function, the Galerkin method, and the Runge–Kutta method. In the numerical results, the effects of geometrical parameters; material properties; imperfections; elastic foundations; electrical, thermal, and damping loads on the vibration and nonlinear dynamic response of the PFGM sandwich plates are discussed. The obtained natural frequencies are verified with the known results in the literature.
A modified new analytical model for low-velocity impact response of circular composite sandwich panels
Authors: Feli S , Khodadadian S , Safari M
Published: May 2016

In this paper, a modified analytical model has been presented for clamped circular composite sandwich panels subjected to low-velocity impact by spherical impactor. The composite sandwich panel is symmetric and its composite face sheets consist of cross-ply laminates. The principle of minimum total potential energy has been used for obtaining the contact force and contact force–indentation relation. In this analytical model, the strain membrane stretching energy and the strain energy due to the bending of face sheet have been determined and the core considered as rigid perfectly plastic. Also, the two degree-of-freedom spring–mass model has been used for determining the contact force history and deflection of the sandwich panel. The analytical contact force and the deflection of sandwich panel have been compared with published experimental and numerical results and good agreement has been observed.
Analysis of laminated composites and sandwich structures by variable-kinematic MITC9 plate elements
Authors: Pagani Alfonso , Valvano Stefano , Carrera Erasmo
Published: May 2016

In this paper, classical as well as various refined plate finite elements for the analysis of laminates and sandwich structures are discussed. The attention is particularly focussed on a new variable-kinematic plate element. According to the proposed modelling approach, the plate kinematics can vary through the thickness within the same finite element. Therefore, refined approximations and layer-wise descriptions of the primary mechanical variables can be adopted in selected portions of the structures that require a more accurate analysis. The variable-kinematic model is implemented in the framework of the Carrera unified formulation, which is a hierarchical approach allowing for the straightforward implementation of the theories of structures. In particular, Legendre-like polynomial expansions are adopted to approximate the through-the-thickness unknowns and develop equivalent single layer, layer-wise, as well as variable-kinematic theories. In this paper, the principle of virtual displacements is used to derive the governing equations of the generic plate theory and a mixed interpolation of tensorial components technique is employed to avoid locking phenomena. Various problems are addressed in order to validate and assess the proposed formulation, including multi-layer plates and sandwich structures subjected to different loadings and boundary conditions. The results are compared with those from the elasticity theory given in the literature and from layer-wise solutions. The discussion clearly underlines the enhanced capabilities of the proposed variable-kinematic mixed interpolation of tensorial component plate elements, which allows, if used properly, to obtain formally correct solutions in critical areas of the structure with a considerable reduction of the computational costs with respect to more complex, full layer-wise models. This aspect results particularly advantageous in problems where localized phenomena within complex structures play a major role.