bluuebunny/crossref_metadata_2025 huggingface dataset:
Achieving Environmentally Responsible Behavior for Tourists and Residents: A Norm Activation Theory Perspective
Authors: Confente Ilenia , Scarpi Daniele
Published: July 2020

Applying Norm Activation Theory to tourism, this study develops a conceptual model for both tourists and residents starting from their awareness of the negative environmental consequences of tourism, addressing ascription of responsibility, environmental sensitivity, place attachment, and environmentally responsible behavior. This research shows that ascription of responsibility mediates the relationship between awareness of negative consequences and that environmentally responsible behavior and environmental sensitivity and place attachment moderate the mediation. Consequently, developing awareness of the consequences of tourism is important to developing strong responsibility ascription and environmentally responsible behavior. The model is split to compare residents and tourists, and systematic differences in the path estimates emerge for the two groups. Furthermore, different types of tourists are compared, revealing that awareness of the negative environmental consequences of tourism and ascription of responsibility are unvaried for new and experienced tourists, but that tourists’ visit length significantly affects both awareness and place attachment.
How Do Older Adults Recruited Using MTurk Differ From Those in a National Probability Sample?
Authors: Ogletree Aaron M. , Katz Benjamin
Published: July 2020

A growing number of studies within the field of gerontology have included samples recruited from Amazon’s Mechanical Turk (MTurk), an online crowdsourcing portal. While some research has examined how younger adult participants recruited through other means may differ from those recruited using MTurk, little work has addressed this question with older adults specifically. In the present study, we examined how older adults recruited via MTurk might differ from those recruited via a national probability sample, the Health and Retirement Study (HRS), on a battery of outcomes related to health and cognition. Using a Latin-square design, we examined the relationship between recruitment time, remuneration amount, and measures of cognitive functioning. We found substantial differences between our MTurk sample and the participants within the HRS, most notably within measures of verbal fluency and analogical reasoning. Additionally, remuneration amount was related to differences in time to complete recruitment, particularly at the lowest remuneration level, where recruitment completion required between 138 and 485 additional hours. While the general consensus has been that MTurk samples are a reasonable proxy for the larger population, this work suggests that researchers should be wary of overgeneralizing research conducted with older adults recruited through this portal.
Why the Son-bias in Caregiving? Testing Sex-differences in the Associations Between Paternal Caregiving and Child Outcomes in England
Authors: Emmott Emily H. , Mace Ruth
Published: July 2020

Studies show that fathers across Western populations tend to provide more care to sons than daughters. Following a human behavioral ecological framework, we hypothesize that son-biases in fathering may (at least in part) be due to differences in fitness returns to paternal direct investments by child’s sex. In this study, we investigate sex-differences in the associations between paternal caregiving and children’s outcomes in stable, two-parent families. Using data from the Avon Longitudinal Study of Parents and Children, we test whether paternal caregiving in early childhood is associated with different effects on children’s school test scores and behavioral difficulties by children’s sex. Overall, we find that paternal caregiving is associated with higher school test scores and lower behavioral difficulty scores, but the association between paternal caregiving and school test scores was stronger for boys. Our findings highlight possible sex-differences in returns to paternal caregiving for certain domains of child outcomes in England.
Cardiac surgeons between apprehension and ethical duty in the COVID-19 pandemic
Authors: Bakry Ahmed MA , Sobhy Ehab , Abdelmohty Hysam
Published: July 2020

Background

Cardiothoracic surgeons are facing a big challenge in their surgical practice in the era of the COVID-19 pandemic. The attitude towards performing surgery is influenced by the pandemic. Setting special recommendations for safe cardiothoracic surgery is of extreme importance.

Methods

This was an observational cross-sectional survey that included 77 Egyptian cardiothoracic surgeons. The survey consisted of a self-administered constructed questionnaire with six sections, and was delivered as a Google Forms questionnaire ( https://www.google.com/forms/about ) that was sent to individuals via social networks and email.

Results

More than 80% of Egyptian cardiothoracic surgeons believe they and their patients are at risk. Out of all participants, none had actually been infected with COVID-19 but 26% had encountered a positive COVID-19 person in their surgical team. Although 51% were testing patients before surgery, they reported 9 confirmed cases postoperatively. Computed tomography was the most recommended investigation prior to surgery (by 69%). Most had postponed elective surgeries and only one-third of all surgeons recommended performing elective surgeries cautiously with pretesting for COVID-19 and maximizing protective measures, while more than 40% recommended not performing high-risk elective surgeries.

Conclusion

We are committed to the safety of our patients, ourselves, our staff, and our families. Planning for the new phase of reopening, whether total reopening or step-by-step reopening, should carefully consider how we should utilize our resources, respect social distancing, and prevent exposure to untested patients or health workers who might turn out to be an undetected positive case.
A Cross-sectional Study of Psychiatric Comorbidity and Severity of Addiction in Patients with Early- and Late-Onset Alcohol Dependence
Authors: Das Anamika , Kar Sujita Kumar , Gupta Pawan Kumar , Dalal Pronob Kumar
Published: July 2020

Background:

Alcohol use disorder is a serious health problem with high comorbidities. Early-onset alcohol use has been associated with greater impulsivity, increased severity of dependence, frequent alcohol withdrawal complications, externalizing symptoms, and antisocial behaviors. We aimed to evaluate the psychiatric comorbidities and severity of addiction in early- and late-onset alcohol dependence.

Methods:

This was a cross-sectional study. All patients fulfilling the diagnostic criteria of alcohol dependence as per International Classification of Diseases (10th edition) were included in it. Semi-Structured Assessment for Genetics of Alcoholism IV was applied to find the age of onset of dependence as per the lifetime frame and also to find comorbidities. Composite International Diagnostic Interview 3.0. was used to find other comorbidities. The severity of addiction was evaluated with Addiction Severity Index, 5th edition. All the sociodemographic and clinical parameters were compared between patients with the early- and late-onset alcohol dependence.

Results:

Out of the 112 patients screened, 57 met the selection criteria, 26 were with early-onset and 31 with late-onset alcohol dependence. The patients were all males. The patients with early-onset alcohol dependence had a higher family history (P = 0.006) and were nonearning (P = 0.002) in comparison to the group with late-onset dependence. The comorbidity among all patients was 59.6% and 84.2% in current and lifetime frames, respectively. It was significantly higher in the early-onset group, both for current (P = 0.015) and lifetime (P = 0.031) frames. On the domains of Addiction Severity Index 5th edition, the early-onset group had a more severe profile of addiction in all domains except the medical domain.

Conclusion:

Comorbidity is high among patients with alcohol dependence and is even higher for the early-onset group. The family history was higher in the early-onset group and they have more severe profile of substance use.
Can Cancer Diagnosis Help in Quitting Tobacco? Barriers and Enablers to Tobacco Cessation Among Head and Neck Cancer Patients from a Tertiary Cancer Center in South india
Authors: Mathew Bincy , Vidhubala E. , Krishnamurthy Arvind , Sundaramoorthy C.
Published: July 2020

Background:

Tobacco use contributes to almost 40% of the cancers in India. Considering the potential threat, many preventive measures have been instigated in the country. However, tobacco cessation for hospitalized cancer patients is an unexplored territory in India. This study aims to understand the quit status and to explore the reasons to quit or continue the use of tobacco after the diagnosis of head and neck cancer (HNC).

Methods:

HNC patients admitted between February and April 2016 were assessed for their tobacco use status. A DT was used to assess the psychological distress. Users were assessed for their readiness to quit and dependence on tobacco. An in-depth interview was conducted among 25 patients (seven current users and 18 recent quitters), and themes that emerged were discussed.

Results:

Of the 119 HNC patients, 71 were tobacco users and 48 had quit tobacco after the diagnosis. The reasons to quit were the perceived benefits of quitting, advice from the physicians, and awareness about cancer and its association with tobacco. In contrast, the reasons to continue the use of tobacco were attributed to coping mechanisms, nihilistic perception about the outcome of the cancer, and a lack of understanding about cancer and its association with tobacco.

Conclusion:

The recent quitters comprehended the benefits of quitting and were able to prioritize their needs after the diagnosis. However, one-third of the HNC patients continued to use tobacco even after the diagnosis of cancer. Hence, tobacco cessation services need to be integrated into oncology services for achieving better treatment outcomes.
A Behavioural-economic Perspective on Conflicts of Interest Among Shareholders, Debtholders, and Directors
Authors: Asaoka Daisuke
Published: July 2020

Corporations have conflicts of interest among shareholders, debtholders and directors, and, corporate law gives each party avenues to pursue others, while protecting themselves. While debtholders are exposed to excessive risk-taking by directors and abuse of limited liability by shareholders, they are protected by legal institutions like directors’ liabilities to third parties and piercing of the corporate veil. Shareholders are subject to the risk of veil-piercing and director negligence, but they are protected by derivative suits. And directors, while under threat of liability suits by debtholders and shareholders, are protected by the business judgement rule, liability exemption and liability insurance of directors and officers (D&O). This web of legal institutions comprises a dual structure of economic and psychological factors, built upon economic incentives but also upon such psychological factors as bounded rationality, the chilling effect, the desire for certainty, loss aversion and the sense of fairness. Any change in the balance will affect their behaviour; greater protection of directors, for example, provokes greater risk-taking, both economically and psychologically.

JEL: K22, G41, D91
Lower extremity coordination during walking in persons who are blind and sighted controls: A preliminary report
Authors: Bennett Hunter J , Valenzuela Kevin A , Sievert Zachary A , Haegele Justin A
Published: July 2020

Walking is the most common mode of physical activity for individuals who are blind. However, this population tends to be physically inactive, possibly due to alterations in coordination patterns during walking. Therefore, the purpose of this study was to examine lower extremity coordination patterns during walking in persons who are blind, and age-, sex-, and body mass index–matched sighted controls. Five persons who are blind performed level walking independently (with a cane) and with a human guide. Sighted controls walked at matched speeds for both conditions. A 10-camera motion capture system was used to record segmental kinematics during both walking conditions. Angle–angle plots and modified vector coding was used to present inter-limb (left/right thigh) and intra-limb (ankle–hip, ankle–knee, and knee–hip) couplings across both walking conditions for each group. Frequency of coupling patterns was compared between groups using Mann–Whitney’s U tests. Inter- and intra-limb coordination patterns were similar between both groups during independent and guided walking conditions (all p > .05). Angle–angle plots depict reduced segmental and joint motion in persons who are blind compared with sighted controls. Although the visual feedback system is integral for coordination during complex tasks, persons who are blind perform level walking with similar lower extremity coordination patterns to sighted controls. Reductions in spatiotemporal and range of motion are likely linked to a more hesitant stepping pattern due to unfamiliarity with the environment.
Responding to the Coronavirus Pandemic: A Tale of Two Cities
Authors: Weng Shi-Hong , Ni Anna Ya , Ho Alfred Tat-Kei , Zhong Ruo-Xi
Published: July 2020

This study compares the experiences of Shanghai in China and Los Angeles in the United States to illustrate four tension points in pandemic responses: immediacy versus thoroughness, transparency versus secrecy and security, centralization versus decentralization, and state-driven solutions versus coproduction. Based on the case analysis, strategic management and planning practices in six stages of pandemic response are recommended. The study also suggests research questions for future comparative research to examine more carefully how pandemic responses should vary due to institutional differences and local contextualization and adaptation.
Creation Processes of Professional Artists and Art Students in Sculpting
Authors: Puppe Linda , Jossberger Helen , Gruber Hans
Published: July 2020

In some creative domains, it is easy to make performance visible. For example, musician can be observed while they perform. In other domains, such as sculpting, less is known about the creation process. The objective of the present study was to analyze how professional artists and students in sculpting differ in their perception and in their creation processes as well as how perception and creation processes are related to each other. Ten experts, 10 intermediates, and 10 novices participated. First, participants’ eye movements while looking at a stimulus were recorded with a remote eye-tracker. Second, they explained which elements of the stimulus were of particular interest for creating a sculpture. Third, they had to create their own sculpture. Finally, questions were asked about their creation processes. The results showed differences between the three groups regarding the start-up period, use of the stimulus, working process, reflection of problems, and final sculptures.
An obstacle disturbance selection framework: emergent robot steady states under repeated collisions
Authors: Qian Feifei , Koditschek Daniel E
Published: July 2020

Natural environments are often filled with obstacles and disturbances. Traditional navigation and planning approaches normally depend on finding a traversable “free space” for robots to avoid unexpected contact or collision. We hypothesize that with a better understanding of the robot–obstacle interactions, these collisions and disturbances can be exploited as opportunities to improve robot locomotion in complex environments. In this article, we propose a novel obstacle disturbance selection (ODS) framework with the aim of allowing robots to actively select disturbances to achieve environment-aided locomotion. Using an empirically characterized relationship between leg–obstacle contact position and robot trajectory deviation, we simplify the representation of the obstacle-filled physical environment to a horizontal-plane disturbance force field. We then treat each robot leg as a “disturbance force selector” for prediction of obstacle-modulated robot dynamics. Combining the two representations provides analytical insights into the effects of gaits on legged traversal in cluttered environments. We illustrate the predictive power of the ODS framework by studying the horizontal-plane dynamics of a quadrupedal robot traversing an array of evenly-spaced cylindrical obstacles with both bounding and trotting gaits. Experiments corroborate numerical simulations that reveal the emergence of a stable equilibrium orientation in the face of repeated obstacle disturbances. The ODS reduction yields closed-form analytical predictions of the equilibrium position for different robot body aspect ratios, gait patterns, and obstacle spacings. We conclude with speculative remarks bearing on the prospects for novel ODS-based gait control schemes for shaping robot navigation in perturbation-rich environments.
Four patients with infarction in key areas of the Papez circuit, with anterograde amnesia as the main manifestation
Authors: Ji Ye , Xie Yanan , Wang Tingting , Cao Duanhua , Li Jin , Han Jingzhe , Ji Guang , Zhao Song , Kang Zhilei
Published: July 2020

The Papez circuit is an important brain structure that is closely associated with learning and memory. In this report, we present four patients with anterograde amnesia as the main manifestation induced by Papez circuit infarction. In addition, we review the distribution of the responsible arteries in key and rare regions to investigate the pathogenesis of these infarctions.
Radiofrequency ablation versus traditional liver resection and chemotherapy for liver metastases from gastric cancer
Authors: Tang Kezhong , Zhang Bo , Dong Linping , Wang Lantian , Tang Zhe
Published: July 2020

Objective

To compare the short- and long-term outcomes of radiofrequency ablation (RFA) versus liver resection and chemotherapy for liver metastases from gastric cancer.

Methods

We retrospectively evaluated 50 patients who underwent curative gastrectomy and local treatments for liver metastases (RFA, n = 20; liver resection, n = 20; and chemotherapy, n = 10) from 2008 to 2018.

Results

The short- and long-term outcomes of each local treatment were evaluated. The median overall survival (OS) after RFA was similar to that after liver resection (20 vs. 20 months, respectively) and longer than that after chemotherapy (20 vs. 10 months, respectively). The 3-year OS and progression-free survival (PFS) rates after RFA were 20% and 10%, respectively, while those in the liver resection group were 23.5% and 23.5%, respectively. The 3-year OS rate after chemotherapy was 10%. The size and number of metastases were prognostic factors for patients with gastric cancer with liver metastasis without statistical significance.

Conclusions

Among patients with liver metastasis from gastric cancer, OS and PFS were satisfactory and comparable between RFA and liver resection but better than those of chemotherapy. RFA is an appropriate option for patients with gastric cancer who have a solitary liver metastasis measuring ≤3.0 cm.
A Combined Orthodontic and Surgical Treatment Approach to Treat Vertically Diverse Skeletal Class II Malocclusions: A Case Series
Authors: Bhattacharya Amit , Trivedi Rahul , Parekh Harshik , Mehta Falguni , Patel Renuka , Tyagi Vidhi
Published: July 2020

Malocclusions in the vertical plane are more difficult to treat as compared to the malocclusions in the sagittal plane as they often require multidisciplinary (surgical) approach. Skeletal vertical deficiency and excess causes jaw discrepancies in the sagittal vector too due to rotation of the mandible, thus presenting a complex situation which requires astute treatment planning and implementation. In this article, two cases treated with combined orthodontics and orthognathic surgery to treat skeletal class II malocclusion with vertical deficiency and excess are shown and all details of treatment planning are discussed.
A Pragmatic Study of the Impact of a Brief Mindfulness Intervention on Prisoners and Staff in a Category B Prison and Men Subject to Community-Based Probation Supervision
Authors: Davies Jason , Ugwudike Pamela , Young Hayley , Hurrell Chloe , Raynor Peter
Published: July 2020

Objectives:

This article presents two studies assessing the impact of mindfulness in prison (prisoners and staff) and non-custodial settings.

Method:

Study 1—prisoners ( n = 17) and staff ( n = 15) in a UK prison completed a mindfulness program; 16 individuals acted as a single time point comparison. Data were collected using self-report, computer based and physiological measurement. Study 2—men under community probation supervision were allocated to mindfulness (completed, n = 28) or TAU ( n = 27). Data were collected using self-report mindfulness measures.

Results:

Study 1—statistically significant (increases in mindfulness skills (η2 p = .234 to η2 p = .388), cognitive control (η2 p = .28), and heart rate variability (SDNN; η2 p = .41) along with significant decreases in stress (η2 p = .398) were found. In study 2, the mindfulness group showed non-significant improvements in mindfulness skills.

Conclusion:

The findings suggest brief mindfulness interventions could make an important contribution to offender rehabilitation and custodial staff wellbeing.
Occupational Therapy for South Asian Older Adults in the United Kingdom: Cross-Cultural Issues
Authors: Yam Nichole , Murphy Angela , Thew Miranda
Published: July 2020

Introduction

There is limited understanding of the cultural needs of diverse Black and Minority Ethnic populations such as South Asian older adults, which may be perpetuating occupational injustices and health inequalities faced by these groups. Although cultural considerations are intrinsic to person-centred occupational therapy and increasingly relevant to the changing landscape of health and social care, the profession is criticised for its western-centric focus. This study aimed to gain understanding of the current cross-cultural issues in supporting South Asian older adults in the UK, as perceived by occupational therapists.

Method

A constructivist qualitative design supported by thematic analysis was used, involving seven occupational therapists in the United Kingdom who participated in semi-structured interviews via Skype/telephone.

Findings

Cross-cultural issues were illustrated through the following themes: ‘when the barriers go down’ – cultural mismatch in individualist vs. collectivist worldviews; ‘invasion of the family home’ – cultural inappropriateness of standard interventions; and ‘I go into every assessment assuming nothing’ – recognition of and response to challenges.

Conclusion

This study provides insight into cross-cultural issues in occupational therapy for South Asian older adults, revealing a gap between theory and practice in integrating cultural humility. It highlights the need for a more inclusive, person-centred approach to support culturally diverse populations.
Full-Scale Evaluation of Concrete-Asphalt Interphase in Thin Bonded Concrete Overlay on Asphalt Pavements
Authors: Paniagua Fabian , Paniagua Julio , Mateos Angel , Wu Rongzong , Harvey John T.
Published: July 2020

Thin bonded concrete overlay on asphalt (BCOA) pavements rely on concrete-asphalt bonding to resist traffic loading. To investigate variables affecting bonding, experimental data were used from 15 instrumented thin BCOA sections, with 11 tested with heavy vehicle simulators (HVS). Sections included three slab sizes, four rapid-strength concrete mixes, new and old asphalt bases, and three asphalt surface texturing techniques. Analysis of strain data from HVS testing served to determine the concrete-asphalt bonding condition. Laboratory testing and forensic data from the sections were also evaluated. Overall, the performance of concrete-asphalt bonding in the sections with 1.8 × 1.8 m (6 × 6 ft) slabs was excellent. In these sections, concrete-asphalt bonding remained intact throughout the HVS testing despite the unfavorable testing conditions, which included flooding of the section, channelized traffic at the slab edge, and HVS wheel (half axle) loading of up to 100 kN (22.5 kips). The sections with 3.6 × 3.6 m (12 × 12 ft) slabs presented a delamination band between the asphalt and concrete along the perimeter of the slabs. This delamination was a tensile break occurring in the asphalt around 5–10 mm (0.2–0.4 in.) below the concrete-asphalt interphase caused by the large vertical hygrothermal deformations in the slabs. Because of this asphalt failure, the concrete and asphalt worked as two independent layers near the transverse joints. Based on laboratory procedures, it was observed that cement paste penetration into the asphalt layer caused a reinforcing effect in the concrete-asphalt interphase. It was also observed that milling and micromilling did not improve the concrete-asphalt bonding.
Operational Evaluation of Effectiveness of Connected Vehicle Smartphone Technology on a Signalized Corridor
Authors: Mjogolo Festo , Sando Thobias
Published: July 2020

Various connected vehicle (CV) technology applications reported in current literature have the potential to solve the challenges faced by the transportation sector. Over the last decade, extensive research efforts have focused on performance evaluation and the benefits of innovative CV applications; findings indicate that CV technology can effectively mitigate the safety, mobility, and environmental challenges experienced on today’s transportation networks. The majority of previous research has evaluated CV technology through simulation studies. However, a field study is the ideal method of assessing CV technology effectiveness. Field observational studies to validate previous research findings have not been conducted. Therefore, a field study to obtain the actual effectiveness of CV technology was warranted, not only to validate previous findings, but to add to the body of knowledge surrounding this topic. This research presents a field study evaluation of the effectiveness of CV smartphone technology on a 1.1-mi segment of State Road 121, containing five intersections, in Gainesville, Florida. Field observations were conducted using a CV application that uses a smartphone application, EnLighten (Connected Signals, Inc., Oregon, United States), to communicate intersection information to a driver’s smartphone, which serves as a vehicle on-board unit. Traffic operation performance was evaluated using a start-up lost time and discharge distribution model. Findings showed that the CV smartphone technology improved intersection performance with a reduction in start-up lost time of approximately 86%. The CV technology had no impact on the distribution model of position-dependent discharge headways.
Children, Income, and the Impact of Home Delivery on Household Shopping Trips
Authors: Spurlock C. Anna , Todd-Blick Annika , Wong-Parodi Gabrielle , Walker Victor
Published: July 2020

Expanding e-commerce and delivery benefit consumers through increased flexibility and convenience. However, there is a potential impact on vehicle miles traveled (VMT) by delivery and personal vehicles, and the resulting energy consumption, air quality, and congestion. Delivery trips could replace personal vehicle trips, but, if not a replacement, could add to (or supplement) shopping-related VMT for a given household. We examined the benefits of e-commerce to consumers and the impact on personal shopping trips, and how these differed across item types, household child status, and income. We found that high-income households and households with children cared relatively more about time saving from deliveries. We found that, on average, deliveries substituted for 12% of vehicle shopping trips, but supplemented personal shopping trips for 9% of purchase deliveries. Underlying these averages were two main types of households: those for whom all deliveries substitute for trips (between 55% and 70% of households) and those for whom all deliveries supplement trips (between 20% and 35% of households). There was significant heterogeneity across households with and without children and with high or low incomes with respect to the use of delivery. Although time savings were more likely to motivate higher-income households and households with children to use delivery, this did not translate through to these households substituting for more of their trips; deliveries of prepared meals for both these categories of household were relatively more likely (15% for households with children, and 12% for higher-income households) to supplement, and not substitute for, personal trips.
Briquetting of sugarcane bagasse as a proper waste management technology in Vietnam
Authors: Brunerová Anna , Roubík Hynek , Brožek Milan , Van Dung Dinh , Phung Le Dinh , Hasanudin Udin , Iryani Dewi Agustina , Herák David
Published: July 2020

The present research describes an application of high-pressure briquetting technology to the waste management of sugarcane processing in Vietnam. The amount of generated sugarcane bagasse was monitored during sugarcane processing within the street juice production in Hue city, Vietnam. Generated sugarcane bagasse was subjected to fuel parameters analysis within its suitability for direct combustion. The obtained sugarcane bagasse was converted into bio-briquette fuel by a high-pressure briquetting press and its mechanical quality was determined. Results proved that the proportion of generated sugarcane bagasse from whole sugarcane stem mass was equal to 35.45%. This indicated generation of an abundant amount of sugarcane bagasse worldwide in general. Fuel parameters analysis proved high quality level of low ash content = 0.97% and high calorific values (gross calorific value = 18.35 MJ·kg-1, net calorific value = 17.06 MJ·kg-1), which indicated good suitability for direct combustion processes. Indicators of mechanical quality proved the following observations: mechanical durability = 99.29%, compressive strength = 150.82 N∙mm-1 and bulk density = 1022.44 kg·m-3, with all these indicators representing positive results. In general, the observed results indicated suitability of sugarcane bagasse valorization within the production of bio-briquette fuel by using high-pressure briquetting technology. Finally, analysis of such waste biomass proved its great potential for energy recovery, thus, the advantage of its valorization within the sustainable technologies.
Thermosensitive nanoparticle of mPEG-PTMC for oligopeptide delivery into osteoclast precursors
Authors: Wang Penghui , Yang Rong , Liu Shuai , Ren Yanhan , Liu Xin , Wang Xiaoxue , Zhang Wenjie , Chi Bo
Published: July 2020

Transmembrane delivery of biomolecules through nanoparticles plays an important role in targeted therapy. Here, we designed a simple nanoparticle for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages) by thermosensitive and biodegradable diblock copolymer monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate). The model peptide drug was encapsulated into the nanoparticle by dropping the drug carrier dissolved in dimethylsulfoxide solvent into water containing poly(vinyl alcohol) to achieve temperature response nanoparticles. Through size analysis, we found that the nanoparticles possessed a temperature-sensitive property between 30°C and 40°C. Moreover, flow cytometry and spectrofluorimetry analysis indicated that nanoparticle systems underwent significant cellular uptake. In addition, the evaluation of cell biology showed that nanoparticles have excellent biocompatibility. Thus, the results indicated that the temperature-sensitive nanoparticles have potential application value for targeted delivery of oligopeptide in the treatment process of osteoarthritis.
Investigating the effect of the aging process on LDPE composites with UV protective additives
Authors: Ovalı Sabih , Sancak Erhan
Published: July 2020

The contact with ultraviolet rays coming from sunlight causes color changes and deterioration in the main chain structures of composites in outdoor applications and affects the physical and mechanical properties of composite materials negatively. Photodegradation can be slowed and the mechanical strength of composite structures can be improved with adding photostabilizers in polymer matrix production. In this study, we modified low-density polyethylene (LDPE) polymer with an amine light stabilizer (Chimassorb 944), a light absorbent (Tinuvin 326), and an antioxidant (Irganox 1010) and then reinforced with jute fabric (JF). We examined the effect of protective additives, which are used to reduce the harmful effects of sunlight, on JF-reinforced LDPE composites. The color change, physical, and mechanical properties of the composites were determined after 120- and 240-h accelerated aging processes. The results indicate that both the antioxidants and the amine light stabilizers were more effective photostabilizers for JF-reinforced LDPE composites than the absorbents.
Advanced development of dairy farm waste-based biocarbon-reinforced unsymmetrical structured bio-phenolic polybenzoxazine composites
Authors: Selvaraj V , Raghavarshini TR , Alagar M
Published: July 2020

In the present work, an attempt has been made to develop cow manure carbon-reinforced hybrid biophenol-based benzoxazine composites for antifouling coating applications. Bio-based benzoxazine with unsymmetrical molecular structure was synthesized using the mixture of a combination of cardanol and eugenol with diaminodiphenyl methane and paraformaldehyde, and the hybrid-benzoxazine obtained was characterized using different analytical techniques, viz., Fourier transform infrared, nuclear magnetic resonance and MALDI mass. Bio-based benzoxazine was further reinforced with varying weight percentages (1, 3 and 5 wt%) of biocarbon derived from cow manure to obtain hybrid composite coatings. The hybrid benzoxazine matrix and composites were studied for their thermal behaviour, contact angle (CA), morphology, corrosion-resistant behaviour and antifouling character to utilize them as coatings materials for different industrial applications. Results obtained from different studies inferred that the biocarbon-reinforced composites possess an enhanced value of glass transition temperature (249°C), high char yield (38.4%), improved CA (105.6°), higher efficiency of corrosion protection against mild steel surface (98%) and improved antimicrobial activity.
Effect of Gurney flap on the aerodynamic behavior of an airfoil in mutational ground effect
Authors: Roozitalab Elham , Kharati-Koopaee Masoud
Published: July 2020

In this research, the effect of Gurney flap on the aerodynamic behavior of an airfoil in mutational ground effect is investigated. To perform this, lift and drag coefficients of NACA 4412 airfoil section in the presence and absence of Gurney flap in mutational ground effect are evaluated and compared. To provide a better illustration of the effect of Gurney flap on the aerodynamic behavior of the airfoil section in the mutational ground effect, results are obtained during the takeoff and landing processes. Validation of the used numerical model is also performed by comparison of the obtained results with those of other works and reasonable agreements were seen. Results show that inclusion of Gurney flap to the airfoil leads to higher variations of lift and drag coefficients during takeoff and landing process. During the takeoff process, the flapped airfoil results in a higher lift decrement and drag increment although an increase in distance of airfoil from the ground or angle of attack causes the lift decrement of the flapped airfoil to get close to that of clean airfoil. It is shown that during takeoff process, downwash is generated around the airfoil as the airfoil leaves the step and as the airfoil gets away from the step, the generated downwash decreases. During the landing process, at each distance of airfoil form the ground and angle of attack, the lift decrement and drag increment of the flapped airfoil are significant compared to that of the clean airfoil. Results exhibit that during landing process, upwash is generated around the airfoil as the airfoil reaches the step and further airfoil move on the step leads to the decrease in the upwash. The decrement in lift coefficient and also the increment in drag coefficient during landing process are more remarkable than those in takeoff process.
Path planning of collision avoidance for unmanned ground vehicles: A nonlinear model predictive control approach
Authors: Hang Peng , Huang Sunan , Chen Xinbo , Tan Kok Kiong
Published: July 2020

In addition to the safety of collision avoidance, the safety of lateral stability is another critical issue for unmanned ground vehicles in the high-speed condition. This article presents an integrated path planning algorithm for unmanned ground vehicles to address the aforementioned two issues. Since visibility graph method is a very practical and effective path planning algorithm, it is used to plan the global collision avoidance path, which can generate the shortest path across the static obstacles from the start point to the final point. To improve the quality of the planned path and avoid uncertain moving obstacles, nonlinear model predictive control is used to optimize the path and conduct second path planning with the consideration of lateral stability. Considering that the moving trajectories of moving obstacles are uncertain, multivariate Gaussian distribution and polynomial fitting are utilized to predict the moving trajectories of moving obstacles. In the collision avoidance algorithm design, a series of constraints are taken into consideration, including the minimum turning radius, safe distance, control constraint, tracking error, etc. Four simulation conditions are carried out to verify the feasibility and accuracy of the comprehensive collision avoidance algorithm. Simulation results indicate that the algorithm can deal with both static and dynamic collision avoidance, and lateral stability.
Archaeological history of Middle Holocene environmental change from fish proxies at the Monte Castelo archaeological shell mound, Southwestern Amazonia
Authors: Prestes-Carneiro Gabriela , Béarez Philippe , Pugliese Francisco , Shock Myrtle Pearl , Zimpel Carlos Augusto , Pouilly Marc , Neves Eduardo Góes
Published: July 2020

Monte Castelo, an archeological shell mound located on the southwestern periphery of the Amazon basin, is an artificial forest island occupied from the Middle to late-Holocene, and it contains one of the longest, continuous sequences of human occupation anywhere in the basin. Analysis of fish remains investigates fluctuations in the fish communities that are markers of changes in the paleoenvironment. The 8112 taxonomically identified remains document diagnostic taxa that are drought-tolerant (armoured catfishes, swamp-eels and tiger fishes) and from swampy environments, indicating probable occupation during low-waters periods. The results from Monte Castelo contrasts with the use of shell mounds as refuges from high-water season floods, a dominant hypothesis. A considerable shift in the nature of the fish spectrum occurred around 4000 BP with increased diversity; the number of taxa jumps from 18 to 48. The Middle Holocene occupations, from 6000 to 4000 BP, reflect long-term stability in drought-tolerant taxa collaborating with paleoecological evidence of dryer conditions. The post 4000 BP introduction of small-sized cichlids and characins suggests an initial exploitation of flooded forests. Archeological fish remains corroborate paleoenvironmental records of increased precipitation between the Middle and Late-Holocene. The probable replacement of some savanna areas by forest vegetation, and the accompanying alteration of aquatic landscapes, is documented through the presence/absence of certain taxa in Monte Castelo’s occupations. This suggests new economic strategies and the exploitation of new ecological niches, as the fish remains correspond to approximately 80% of the vertebrate fauna throughout the archeological sequence.
Nonlinear parametric quantile models
Authors: Bottai Matteo , Cilluffo Giovanna
Published: July 2020

Quantile regression is widely used to estimate conditional quantiles of an outcome variable of interest given covariates. This method can estimate one quantile at a time without imposing any constraints on the quantile process other than the linear combination of covariates and parameters specified by the regression model. While this is a flexible modeling tool, it generally yields erratic estimates of conditional quantiles and regression coefficients. Recently, parametric models for the regression coefficients have been proposed that can help balance bias and sampling variability. So far, however, only models that are linear in the parameters and covariates have been explored. This paper presents the general case of nonlinear parametric quantile models. These can be nonlinear with respect to the parameters, the covariates, or both. Some important features and asymptotic properties of the proposed estimator are described, and its finite-sample behavior is assessed in a simulation study. Nonlinear parametric quantile models are applied to estimate extreme quantiles of longitudinal measures of respiratory mechanics in asthmatic children from an epidemiological study and to evaluate a dose–response relationship in a toxicological laboratory experiment.
Development and characterization of novel castor oil-based polyurethane composites containing wood sawdust and rubber tire powder
Authors: Seibel Rodrigo Konzen , Zimmer André , Fiorio Rudinei
Published: July 2020

New eco-friendly composites consisting of castor oil-based polyurethane (PU) resin, wood sawdust, and rubber tire powder were produced, and the morphological, physical, and flexural properties were investigated. The composites were composed of varying the concentration of the PU matrix (30, 40, and 50 m%) and the wood-to-rubber ratio of the disperse phase (100/0, 90/10, 80/20, 70/30, 60/40, and 50/50 m%/m% wood/rubber, respectively). The morphology of the composites was studied by optical microscopy and scanning electron microscopy, and the flexural properties, water absorption (WA), and thickness swelling (TS) were also investigated. The analysis of variance was used to study the effect of each factor (PU content and wood/rubber ratio) on the characteristics of the composites. PU/wood/rubber composites were successfully molded and their characteristics are promising for commercial use. According to the results, the composites presenting higher wood content (high wood/rubber ratio) showed higher modulus of rupture and modulus of elasticity values, although the addition and the increase of rubber content decreased these properties. Moreover, increasing PU or reducing the wood/rubber ratio significantly reduced the WA and TS, improving dimensional stability.
Supporting Children’s Well-being with Art in Nature: Artist Pedagogue Perceptions
Authors: Walshe Nicola , Lee Elsa , Smith Millie J.
Published: July 2020

There is increasing concern about children’s mental well-being and an urgent need for research into how to support positive mental health; including as part of the United Nations Sustainable Development Goals (SDGs). Alongside this is the heightened awareness about diminished access to green spaces and diminished exposure to the arts for children. Our research aims to show the potential for addressing these three issues in tandem through a qualitative case study exploring the work of one charity, Cambridge Curiosity and Imagination (CCI). The charity undertakes arts-based projects in nature with children. In particular, this article considers the implications of CCI artist pedagogues’ perceptions of their nature-based practice for children’s well-being. The research comprised a ‘talk and draw’ focus group followed by individual interviews with CCI artists. Findings show artist pedagogues’ work has the potential to support aspects of children’s well-being through promotion of agency, developing confidence and providing inspiration to support creativity.
Factors That Influence Curricular Adoption in a Sustainability Focused Marine Science Professional Development for In-Service Teachers
Authors: Goodale Timothy A.
Published: July 2020

The focus of this article is on the evaluation and outcomes of a professional learning opportunity that focused on 13 current K–12 public school science educators in the United States. This teacher training concentrated on sustainability education that utilized marine sciences as a unifying concept. Findings from this training helped to identify models within teacher professional development in marine science that lead to comprehensive adoption of presented curricula. Four established models/frameworks of professional development were identified and their subsequent classroom implementation was evaluated. Results include adoption rates of the various session materials, the impact and effect size of differing variables (such as deliverables or standards alignment) among the four models and their frameworks and changes in perceptions towards sustainability initiatives. These outcomes underscore several methods and strategies for successful science teacher professional development implementation in regard to marine sciences.
Prevalence of PKD1 gene mutation in cats in Turkey and pathogenesis of feline polycystic kidney disease
Authors: Bilgen Nüket , Bişkin Türkmen Merve , Çınar Kul Bengi , Isparta Sevim , Şen Yusuf , Akkurt Mustafa Y. , Çıldır Özge Ş. , Bars Zeynep
Published: July 2020

Polycystic kidney disease (PKD) is one of the most common hereditary diseases in cats, with high prevalence in Persian and Persian-related cats. PKD is caused mainly by an inherited autosomal dominant (AD) mutation, and animals may be asymptomatic for years. We screened 16 cats from various breeds exhibiting a renal abnormality by ultrasound examination and genotyped them for the c.10063C>A transversion on exon 29 of the polycystin-1 ( PKD1) gene, by PCR–restriction fragment length polymorphism (PCR-RFLP). Among these cats, a Siamese nuclear family of 4 cats with ancestral hereditary renal failure were screened by whole-genome sequencing (WGS) to determine novel variations in genes associated with both AD and autosomal recessive PKD in humans. During the study period, one cat died as a result of renal failure and was forwarded for autopsy. Additionally, we screened 294 cats asymptomatic for renal disease (Angora, Van, Persian, Siamese, Scottish Fold, Exotic Shorthair, British Shorthair, and mixed breeds) to determine the prevalence of the mutation in cats in Turkey. Ten of the symptomatic and 2 of the asymptomatic cats carried the heterozygous C → A transversion, indicating a prevalence of 62.5% and 0.68%, respectively. In the WGS analysis of 4 cats in the Siamese nuclear family, novel variations were determined in the fibrocystin gene ( PKHD1), which was not compatible with dominant inheritance of PKD.
Multilobular tumor of bone on the forehead of a guinea pig
Authors: Hatai Hitoshi , Kido Nobuhide , Ochiai Kenji
Published: July 2020

Multilobular tumor of bone (MLTB) is an infrequent, slow-growing, bone neoplasm formed predominantly on the head. These tumors can behave as malignant neoplasms clinically and pathologically and can metastasize occasionally. No cases of MLTB in rodents have been reported, to our knowledge. We describe a novel case of an MLTB in a guinea pig. An adult guinea pig had an exophytic mass fixed on the frontal bone, maxilla, and nasal bone. On radiography, the mass had a spherical contour and variable density and was formed on the surface of the cranial bones. The mass was excised surgically. The cut surface was light-yellow to milky-white and had a granular texture with fine fibrous septa. Histologically, the neoplasm had a multilobular pattern, which consisted of many islands of bone and/or cartilage matrix surrounded by small cells and separated by fibrous septa, which closely resembles the equivalent neoplasm in dogs.