bluuebunny/crossref_metadata_2025 huggingface dataset:
Borderline We-Space? The Phenomenology of the Background of Safety in Borderline Personality Disorder
Authors: Van Duppen Zeno , Schmidt Philipp , Lowyck Benedicte
Published: December 2021

Borderline personality disorder (BPD) is a severe psychiatric condition characterized by instability in identity, relationships, and affect. Individuals, with BPD typically lack a coherent sense of self, are highly sensitive to interpersonal stressors, experience intense fluctuations in mood, and frequently engage in impulsive and self-destructive behaviors. Although both empirical research and development of effective psychotherapy have evidently progressed over the past years, many aspects regarding the structure of experience and the life-world typical for persons with BPD are not yet fully understood. Somewhat surprisingly, phenomenological psychopathology has only recently started to pay more attention to the disorder. A comprehensive elaboration of the phenomenology of BPD is therefore still lacking. This article aimed to contribute to such a phenomenological understanding by focusing on what we think is an essential aspect that has yet not been sufficiently addressed: the background of safety. To clarify what this means, we depart from Sandler’s [Int J Psychoan. 1960;41:352–6] psychoanalytic concept and elaborate on it phenomenologically. This leads us to argue that the development of a background of safety requires a particular embodied presence of others, which, in turn, contributes to the constitution of a safe we-space, a shared and familiar environment providing a matrix for the experience of a stable world. However, even when established, the background of safety remains in need of a continuous reconfirmation through corresponding experiences within a sufficiently reliable and controllable environment. The background of safety is vulnerable and open to (interpersonal) disruptions like trauma or neglect. In BPD, we suggest 3 aspects regarding the phenomenology of the background of the safety need to be considered: first, typically, patients with BPD did not develop a robust background of safety in infancy; second, weakening of the background of safety gives rise to symptoms and dynamics typical for BPD; third, these symptoms and dynamics further undermine the possible development of a background of safety in adult life and thus gravitate toward a petrification of the borderline condition, a “stable instability.” To conclude, we examine whether this concept should be understood as a trouble générateur and, last, consider its clinical implications.
Long-Term Survival With Tafamidis in Patients With Transthyretin Amyloid Cardiomyopathy
Authors: Elliott Perry , Drachman Brian M. , Gottlieb Stephen S. , Hoffman James E. , Hummel Scott L. , Lenihan Daniel J. , Ebede Ben , Gundapaneni Balarama , Li Benjamin , Sultan Marla B. , Shah Sanjiv J.
Published: December 2021

Background:

Tafamidis is approved in many countries for the treatment of transthyretin amyloid cardiomyopathy. This study reports data on the long-term efficacy of tafamidis from an ongoing long-term extension (LTE) to the pivotal ATTR-ACT (Tafamidis in Transthyretin Cardiomyopathy Clinical Trial).

Methods:

Patients with transthyretin amyloid cardiomyopathy who completed ATTR-ACT could enroll in an LTE, continuing with the same tafamidis dose or, if previously treated with placebo, randomized (2:1) to tafamidis meglumine 80 or 20 mg. All patients in the LTE transitioned to tafamidis free acid 61 mg (bioequivalent to tafamidis meglumine 80 mg) following a protocol amendment. In this interim analysis, all-cause mortality was assessed in patients treated with tafamidis meglumine 80 mg in ATTR-ACT continuing in the LTE, compared with those receiving placebo in ATTR-ACT transitioning to tafamidis in the LTE.

Results:

Median follow-up was 58.5 months in the continuous tafamidis group (n=176) and 57.1 months in the placebo to tafamidis group (n=177). There were 79 (44.9%) deaths with continuous tafamidis and 111 (62.7%) with placebo to tafamidis (hazard ratio, 0.59 [95% CI, 0.44–0.79];
P
<0.001). Mortality was also reduced in the continuous tafamidis (versus placebo to tafamidis) subgroups of: variant transthyretin amyloidosis (0.57 [0.33–0.99];
P
=0.05) and wild-type transthyretin amyloidosis (0.61 [0.43–0.87];
P
=0.006); and baseline New York Heart Association class I and II (0.56 [0.38–0.82];
P
=0.003) and class III (0.65 [0.41–1.01];
P
=0.06).

Conclusions:

In the LTE, patients initially treated with tafamidis in ATTR-ACT had substantially better survival than those first treated with placebo, highlighting the importance of early diagnosis and treatment in transthyretin amyloid cardiomyopathy.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01994889 and NCT02791230.
Description of Nola estonica sp. nov., with comparison to N. aerugula and N. atomosa stat. rev. (Lepidoptera, Nolidae, Nolinae)
Authors: ÕUNAP ERKI , CHOI SEI-WOONG , MATOV ALEXEY , TAMMARU TOOMAS
Published: December 2021

Nola estonica Õunap sp. nov. (Lepidoptera, Nolidae, Nolinae) is described based on type material from Estonia. The lectotype is designated for Glaphyra atomosa Bremer, 1861, which is reinstated from a subspecies of Nola aerugula (Hübner, [1793]) to a full species: Nola atomosa (Bremer, 1861) stat. rev. The status of these three taxa as separate species is supported by the results of phylogenetic analysis of DNA barcodes, as well as external and genital morphology of adult specimens. Two new synonyms are established as follows: Nola atomosa (Bremer, 1861) = Nola candidalis Staudinger, 1892 syn. nov. and Nola shin Inoue, 1982 syn. nov. N. estonica occurs sympatrically with N. aerugula in Estonia, and with N. atomosa in South Korea and easternmost Russia. While the available data suggest a disjunct distribution of N. estonica (eastern Europe and the temperate Far East), it appears highly possible that the species has a wide transpalaearctic distribution.
Cold from Gold: Chinese Miners Face New Realities in Ghana
Authors: Nkrumah Daniel , Bekoe Daniel Norris
Published: December 2021

China has maintained strong relationships with many African countries, and Ghana is one such country. While the two countries have normally enjoyed good friendly relations, concerns over the involvement of Chinese citizens in small-scale mining in Ghana threaten the cordial relationship between the two countries.

There is evidence of a cultural evolution and a gradual shift from a culture of enthusiastic reception of local people to the Chinese in the area of mining to one of cold reception to Chinese interests in mining communities. There is also evidence that this cold reception to Chinese miners is stimulated by non-state actors led by the media and inspires in Ghana a new paradigm of more rational engagement with China at the political level, although challenges still remain.
Research on green single machine scheduling based on improved ant colony algorithm
Authors: Qiao Dongping , Wang Yajing , Pei Jie , Bai Wentong , Wen Xiaoyu
Published: December 2021

This paper studies the green single-machine scheduling problem that considers the delay cost and the energy consumption of manufacturing equipment and builds its integrated optimization model. The improved ant colony scheduling algorithm based on the Pareto solution set is used to solve this problem. By setting the heuristic information, state transition rules, and other core parameters reasonably, the performance of the algorithm is improved effectively. Finally, the model and the improved algorithm are verified by the simulation experiment of 10 benchmark cases.
Coping, Not Choking, Under the Pressure of a Terrorist Attack: A Crisis Leadership Coping Model
Authors: Nesse Synnøve , Stensaker Inger G.
Published: December 2021

Organizational crises, especially those of an extreme nature that include threats to survival and mass casualties, are deeply psychologically challenging for leaders. Previous research has focused on the effectiveness of leaders’ crisis management without much consideration for how leaders manage their own crisis reactions. This study was carried out in the crisis management facilities at the headquarters of a multinational energy corporation while a terrorist attack was ongoing in one of its subsidiaries. The unique access and data provide insights into how leaders react to crises and seek support by using different coping strategies. We develop a three-phase model (acceptance, psychological flexibility, and commitment) that illustrates the in-situ creation of a holding environment to support leaders in coping, not choking, under the pressure of a life-threatening crisis.
Undergraduate Students Engagement in Formal and Informal Learning: Applying the Community of Inquiry Framework
Authors: Chatterjee Suparna , Parra Julia
Published: December 2021

The purpose of this qualitative case study is to examine the evidence of formal and informal learning of students in an undergraduate educational technology course for preservice teachers. The research question was, “How do undergraduate students in an educational technology course bridge formal and informal learning using Twitter?” The framework for this study was the Community of Inquiry. Directed content analysis was used on data extracted from Twitter. Key findings included, (1) evidence of cognitive, social, and teaching presence for students completing course activities using Twitter, that is, for their formal learning; and that (2) students developed competencies during formal course activities using Twitter that supported cognitive and social presence beyond the course requirements, that is, for their informal learning.
Conceptualizing religious asylum: Security, religiosity, and subjective well-being of Christian asylum-seekers in Hong Kong
Authors: Shum Terence Chun Tat
Published: December 2021

This article proposes the concept of religious asylum to examine how Christian asylum-seekers utilize religion to cope with their emotional experiences, induced by a sense of insecurity, during prolonged displacement. Drawing from interviews and ethnographic observations of people seeking asylum in Hong Kong, this research determines that asylum-seekers use religion to redefine their positive sense of self beyond their current situation, which is central to the construct of well-being. While religion supports asylum-seekers going through psychosocial distress and suffering, this discussion on religious asylum shows how asylum-seekers utilize the religiously inflected space to make the experience of prolonged displacement meaningful.
Distinct features of brain perivascular fibroblasts and mural cells revealed by in vivo two-photon imaging
Authors: Bonney Stephanie K , Sullivan Liam T , Cherry Timothy J , Daneman Richard , Shih Andy Y
Published: December 2021

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central nervous system disorders. Like mural cells, PVFs surround blood vessels and express Pdgfrβ. However, these shared attributes hinder the ability to distinguish PVFs from mural cells. We used in vivo two-photon imaging and transgenic mice with PVF-targeting promoters (Col1a1 or Col1a2) to compare the structure and distribution of PVFs and mural cells in cerebral cortex of healthy, adult mice. We show that PVFs localize to all cortical penetrating arterioles and their offshoots (arteriole-capillary transition zone), as well as the main trunk of only larger ascending venules. However, the capillary zone is devoid of PVF coverage. PVFs display short-range mobility along the vessel wall and exhibit distinct structural features (flattened somata and thin ruffled processes) not seen with smooth muscle cells or pericytes. These findings clarify that PVFs and mural cells are distinct cell types coexisting in a similar perivascular niche.
Diagnostic performance of MRI and endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy: a systematic review of the literature
Authors: Munk Nicolai Egholt , Bondeven Peter , Pedersen Bodil Ginnerup
Published: December 2021

Background

The diagnostic performance of magnetic resonance imaging (MRI) modalities and/or endoscopy for assessing complete response in rectal cancer after neoadjuvant chemoradiotherapy (nCRT) is unclear.

Purpose

To summarize existing evidence on the diagnostic performance of diffusion-weighted MRI, perfusion-weighted MRI, T2-weighted MR tumor regression grade, and/or endoscopy for assessing complete tumor response after nCRT.

Material and Methods

MEDLINE and Embase databases were searched. The PRISMA guidelines were followed. Sensitivity, specificity, negative predictive, and positive predictive values were retrieved from included studies.

Results

In total, 81 studies were eligible for inclusion. Evidence suggests that combined use of MRI and endoscopy tends to improve the diagnostic performance compared to single imaging modality. The positive predictive value of a complete response varies substantially between studies. There is considerable heterogeneity between studies.

Conclusion

Combined re-staging tends to improve diagnostic performance compared to single imaging modality, but the vast majority of studies fail to offer true clinical value due to the study heterogeneity.
Giant hysteromyoma after vaginoplasty in a woman with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: case report and review of the literature
Authors: Qiu Shikang , Xie Yunkai , Zou Yonghui , Wang Fei
Published: December 2021

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital disorder characterized by congenital absence of both the uterus and vagina. Some patients require surgery to create a neovagina, however, the preservation of a nonfunctional rudimentary uterus after surgery may lead to long-term complications. Herein, a rare case of a giant hysteromyoma after vaginoplasty, in a 31-year-old Chinese female patient who was diagnosed with MRKH syndrome, is reported. The patient, who had undergone vaginal reconstruction 4 years previously, presented with abdominal distension for the previous 2 weeks. Transabdominal ultrasonography showed a firm mass of approximately 10 × 10 cm in the lower abdomen. The patient subsequently underwent an exploratory laparotomy, and a leiomyoma from her rudimentary uterus was removed. Beside this case, seven cases, published between 2004 and 2020, were identified during a literature search. Findings of the present and previously published cases suggest that gynaecologists should pay particular attention to the risks of pelvic complications in female patients with MRKH syndrome who have previously undergone surgery, and select appropriate therapeutic methods.
Progress in simulating human geography: Assemblage theory and the practice of multi-agent artificial intelligence modeling
Authors: LeRon Shults F.
Published: December 2021

Over the last few years, there has been an explosion of interest in assemblage theory among human geographers. During this same period, a growing number of scholars in the field have utilized computational methodologies to simulate the complex adaptive systems they study. However, very little attention has been paid to the connections between these two developments. This article outlines those connections and argues that more explicitly integrating assemblage theory and computer modeling can encourage a more robust philosophical understanding of both and facilitate progress in scientific research on the ways in which complex socio-material systems form and transform.
An analysis method for the performance of compliant cylindrical intershaft gas film seal considering centrifugal expansion effect
Authors: Hou Guoqiang , Su Hua , Chen Guoding
Published: December 2021

A compliant cylindrical gas film seal has the potential to adapt to the complex operating conditions of a dual-rotor aeroengine, with radial runout and eccentricity, due to its special structural characteristics. To accurately investigate the seal performance of a compliant cylindrical gas film seal on dual-rotor shafts, an aeroelastic coupling method is proposed. This method analyzes the performance of a compliant cylindrical intershaft gas film seal by taking the centrifugal expansion effect into consideration. The seal performance under homodromy and counter-rotating conditions, with and without the centrifugal expansion effect, is calculated, and various performance parameters are compared and analyzed. Furthermore, the influence mechanism of the direction of rotation of the two rotors on seal performance is revealed. The results show that seal performance under homodromy condition is greater than under counter-rotating condition, and for an aeroengine under homodromy condition, it is advantageous to apply the compliant cylindrical intershaft gas film seal. The effect of centrifugal expansion (in large-diameter and high-speed rotors) and rotor eccentricity on the performance of a compliant cylindrical intershaft gas film seal, as well as the impact of inner and outer rotor speed on leakage rate, are analyzed and presented in this study. The proposed aeroelastic coupling method provides a promising guidance for the performance analysis of the compliant cylindrical gas film seal in single and dual- rotor systems.
Strength-based design of a sunflower stalk cutter machine design using finite element analysis and experimental validation
Authors: İrsel Gürkan
Published: December 2021

In this study, the total algorithm of the strength-based design of the system for mass production has been developed. The proposed algorithm, which includes numerical, analytical, and experimental studies, was implemented through a case study on the strength-based structural design and fatigue analysis of a tractor-mounted sunflower stalk cutting machine (SSCM). The proposed algorithm consists of a systematic engineering approach, material selection and testing, design of the mass criteria suitability, structural stress analysis, computer-aided engineering (CAE), prototype production, experimental validation studies, fatigue calculation based on an FE model and experimental studies (CAE-based fatigue analysis), and an optimization process aimed at minimum weight. Approximately 85% of the system was designed using standard commercially available cross-section beams and elements using the proposed algorithm. The prototype was produced, and an HBM data acquisition system was used to collect the strain gage output. The prototype produced was successful in terms of functionality. Two- and three-dimensional mixed models were used in the structural analysis solution. The structural stress analysis and experimental results with a strain gage were 94.48% compatible in this study. It was determined using nCode DesignLife software that fatigue damage did not occur in the system using the finite element analysis (FEA) and experimental data. The SSCM design adopted a multi-objective genetic algorithm (MOGA) methodology for optimization with ANSYS. With the optimization solved from 422 iterations, a maximum stress value of 57.65 MPa was determined, and a 97.72 kg material was saved compared to the prototype. This study provides a useful methodology for experimental and advanced CAE techniques, especially for further study on complex stress, strain, and fatigue analysis of new systematic designs desired to have an optimum weight to strength ratio.
What if? Epidemic discourse and serial narration in the alternate history series La Révolution (2020)
Authors: Wörsdörfer Anna Isabell
Published: December 2021

The article examines the formal and thematic manifestations of seriality in the Netflix series La Révolution, which justifies the revolutionary outbreak in a counterfactual plot with a viral outbreak that turns the nobles into zombie-like monsters. While, on a macrostructural level, the generic frame of alternate history promotes the serial character through the varying repetition of the historical event, the microstructural level of the narration evokes seriality by exponential contagion and spread of the disease as well as an increasing spiral of violence. First, the focus is on the representation of the aristocrat as a monster in pamphlets and caricatures of the revolutionary era. Subsequent to a contextualization of seriality in the age of streaming platforms, the analysis then discusses the medium-specific implementation of the epidemic discourse based on selected sequences of the series. Finally, it gives a hypothetical outlook on the implied motivations regarding the fictional development of the revolutionary event: through its contrasting exaggeration, the alternate-historical narrative can shed new light on the real historical events.
Gender Discourses and the Making of the Indian Constitution
Authors: Dhingra Alisha
Published: December 2021

Indian democracy was constituted after a long struggle for self- determination, which ultimately culminated in the making of a constitution for independent India. This article seeks to revisit gender discourses during the constituent assembly debates when women members were seeking for complete gender equality to be written into the constitution. The nationalist discourses on ‘Indian womanhood’ prevalent during the years of the freedom struggle were articulated and reflected in the debates and impacted the writing of the text of the constitution. The final text contains gender progressive provisions on which consensus had been achieved during the nationalist struggle but excludes explicit provisions that would have challenged the roots of patriarchal structures. Thus, while the nationalist movement provided a platform for women to organise for their rights, it also constrained the agenda of transformation.
Prediction Model of in-Hospital Venous Thromboembolism in Chinese Adult Patients after Hernia Surgery: The CHAT Score
Authors: Gu Zhi-Chun , Zhang Chi , Yang Ya , Wang Ming-Gang , Li Hang-Yu , Zhang Guang-Yong
Published: December 2021

Background

Venous thromboembolism (VTE) events after hernia surgery influence prognosis and life quality and may be preventable. This study aimed to develop a useful model for predicting in-hospital VTE in Chinese patients after hernia surgery.

Methods

Patients after hernia surgery were retrospectively recruited from 58 institutions (n = 14 322). Totally, 36 potential predictors were involved in the regression analysis. Weighted points were assigned to the predictors of in-hospital VTE identified in the multivariate logistic regression analysis and a prediction model was established. Decision curve analysis was performed to evaluate the net clinical benefit between the established and Caprini models.

Results

A total of 11 707 patients were included and five variables were explored as predictors related to in-hospital VTE: varicose veins of lower extremity, history of VTE, family history of thrombosis, interruption of antithrombotic agents, and reducible hernia. The prediction model (the CHAT score) revealed a good performance metrics (c-statistic, 0.81 [95% CI, 0.80 to 0.81]; Nagelkerke R2, 0.27 [95% CI, 0.26 to 0.30]; Brier score, 0.16 [95% CI, 0.13 to 0.23]). The rate of in-hospital VTE after hernia surgery at low-risk (−4 points), intermediate-risk (0-1 points), high-risk (4 points) and very high-risk (≥5 points) were 0.05%, 0.39%, 0.73% and 8.62%, respectively. The CHAT score identified a considerable variability (from 0.05% to 8.62%) for in-hospital VTE among the overall population after hernia surgery. Decision curve analysis found a superior net benefit of the established model than the Caprini score.

Conclusions

The CHAT score is likely to be a practical 5-item supporting tool to identify patients at high risk of in-hospital VTE after hernia surgery that might assist in decision making and VTE prevention. Further validated study will strengthen this finding.
Onco-pharmacist led evaluation of knowledge, attitude & practice (KAP) of safe handling cytotoxic drugs among health care professional's (HCP's) in tertiary care hospital: A hospital based interventional Study
Authors: Gudhoor Manjula , Ganachari Madiwalayya Shivakantayya , K Jyoti , Salimath Geetanjali S
Published: December 2021

Background

Cytotoxic drugs (CDs) are hazardous in nature. But it is necessary for the treatment in cancer patients. The healthcare professionals (HCPs) act as a facilitator through which the manufactured CDs reach the patient. However, safe handling of CDs becomes a primary concern not only for the recipients but also for the HCPs.

Methods

On Ethics committee approval, a prospective- interventional study was conducted among HCPs who are involved in handling of CDs in Oncology department of tertiary care hospital. The participants were screened for their eligibility criteria & 73 HCPs were recruited. The initial data was collected from the HCPs through interview & questionnaires. Later the participants were trained by oncology-pharmacist (7–8 months) for safe handling of CDs. After the training the participants were tested again through interview & questionnaires.

Results

73 participants, (75%) nurses & (25%) physicians were included in the study. Among these participants, only 32.87% underwent training on reconstitution whereas 67.12% of the participants didn't undergo any training. The increase in mean score of KAP after the training was observed to be 3.44 ± 4.32, 1.23 ± 1.51 and 1.3 ± 1.01 respectively.

Conclusion

The study concludes that mandatory requirement of training for HCPs using SOP's by qualified oncology-pharmacist to minimize the hazardous effects of CDs. It also highlights the improvisation techniques for handling of CDs will enhance the safety profile of HCPs & the patients, which helps in refining the quality of pharmaceutical and health care services provided in the cancer care settings.
Bilateral laser peripheral iridotomy in a co-occurrence of unilateral iridocorneal endothelial syndrome and chronic angle closure glaucoma
Authors: Ahluwalia Navjot Singh , Shakya Rakesh , Parikh Dhairya
Published: December 2021

Purpose

To report a case of unilateral Iridocorneal endothelial (ICE) syndrome- Progressive iris atrophy (PIA) with an overlapping chronic angle closure glaucoma (CACG) and to highlight the effect of bilateral Laser peripheral iridotomy (LPI) in such a co-occurrence.

Case description

A patient presented to us with bilateral gradual painless progressive diminution of vision. Both eyes (BE) had a clear cornea, shallow peripheral anterior chamber depth, grade 2 nuclear sclerosis, raised intraocular pressure and glaucomatous optic neuropathy. In addition, the Left eye (LE) had an irregular anterior chamber, peripheral anterior synechiae (PAS) extending to cornea, patchy iris atrophy, subtle corectopia and a low endothelial cell count on specular microscopy. Indentation gonioscopy led to the diagnoses of CACG BE with ICE syndrome- PIA LE. LPI was performed bilaterally. On Anterior Segment Optical Coherence Tomography (ASOCT), there was evident widening of the angle away from PAS in the Right eye as well as in the LE with PIA post LPI.

Conclusion

This is a unique case of unilateral PIA with an associated CACG in BE. It is the first case demonstrating the effect of bilateral LPI in such a case scenario. Though not indicated in ICE syndrome, LPI did show short term evidence of significant widening of the angle away from areas of PAS even in the eye with PIA having a limited high PAS and a concurrent primary (chronic) angle closure disease.
The Belt and Road Initiative in Australian mainstream media: why did its narratives shift from 2013 to 2021?
Authors: Jiang Yuan
Published: December 2021

Compared with similar research mainly focusing on the Belt and Road Initiative (BRI) in Australian mainstream media using discourse analysis, this paper explores the reasons for the narrative shift by conducting semi-structured interviews with leading and well-known Australian narrative producers. This paper takes two conditions as a given. Firstly, the BRI narratives in Australian mainstream media shifted in tone from mostly positive to highly critical. Secondly, the Australian mainstream media's increasingly negative attitudes towards the BRI are essentially not just about the BRI but the Chinese government. Based on my analysis and interviews, this paper makes contributions by filling in the gap of finding out reasons to explain this narrative shift. More concretely, this paper finds out that while mainstream media is influential in many areas of national policy making, mainstream media reporting on foreign affairs is less so. By comparison, the Australian government's BRI or China policy has a significant impact on Australian mainstream media reporting. This narrative shift has been driven by international politics and Australia's China policy, influenced by Australian audiences’ preference of local news and their local position, and its democratic responsibilities. Meanwhile, the vagueness and constant changing characteristics of the BRI do not help the understanding of the BRI in Australian media.
The Impacts of Extreme Weather Events on Inflation and the Implications for Monetary Policy in Africa
Authors: Kunawotor Mark Edem , Bokpin Godfred Alufar , Asuming Patrick O. , Amoateng Kofi A.
Published: December 2021

Economic debates around mitigating climate change and weather-related events have long centred on fiscal policy tools than those of monetary policy. However, recent discussions point out that monetary policy formulation could also be affected and hence the need to deploy monetary policy tools as well. Our article seeks to investigate the impacts of climate change, particularly extreme weather events, on headline inflation and food price inflation and their apparent implications for monetary policy in Africa over the period 1990–2017. Using a two-step dynamic system Generalized Method of Moments estimation strategy with robust standard errors, we find that weather-related events may need to be large and consequential to cause a significant price hike in Africa. We also find the incidence of droughts and floods to have a bearing on food price inflation. Furthermore, our empirical evidence using mediation analysis, reveals agricultural production to be the critical mechanism whereby extreme weather events affect headline inflation. As central banks are charged with the mandate of ensuring a stable monetary environment, we suggest that monetary policy authorities consider the short and long run impacts of supply shocks caused by extreme weather events on general price levels in their policy formulation.
Bargaining power in informal trilogues: Intra-institutional preference cohesion and inter-institutional bargaining success
Authors: Haag Maximilian
Published: December 2021

Informal trilogue meetings are the main legislative bargaining forum in the European Union, yet their dynamics remain largely understudied in a quantitative context. This article builds on the assumption that the negotiating delegations of the European Parliament and the Council play a two-level game whereby these actors can use their intra-institutional constraint to extract inter-institutional bargaining success. Negotiators can credibly claim that their hands are tied if the members of their parent institutions hold similar preferences and do not accept alternative proposals or if their institution is divided and negotiators need to defend a fragile compromise. Employing a measure of document similarity (minimum edit distance) between an institution's negotiation mandate and the trilogue outcome to measure bargaining success, the analysis supports the hypothesis for the European Parliament, but not for the Council.
Wage Dispersion and Team Performance: The Moderation Role of Club Size
Authors: Gasparetto Thadeu , Barajas Angel
Published: December 2021

Previous research on professional football offer conflicting results regarding the impact of wage dispersion on team performance. However, the existing intra-league heterogeneity among clubs is overlooked and could be the reason for the diverging outcomes. The aim of this paper is to reanalyze this relationship having the clubs’ size as moderator. Payroll – which captures the financial strength – is used as proxy of club size. Ordinary Least Squares regressions with season and league fixed effects are employed. Dispersion is measured by three indexes for robustness check. The outputs confirm the quadratic relationship between wage dispersion and performance, but adding that identical levels of dispersion have different impact on football clubs according to their financial strength.
Awareness, Use and Outlook of Complementary and Alternative Medicine (CAM) Options in an Underserved, Uninsured Minority Cancer Patient Population
Authors: Bari Shahla , Chineke Iloabueke , Darwin Alicia , Umar Anam , Jim Heather , Muzaffar Jameel , Singh Shailesh , Kucuk Omer
Published: December 2021

Integrative oncology aims to coordinate the delivery of conventional medicine and evidence-supported complementary and alternative medicine (CAM) to patients receiving cancer care. This field developed out of an increased interest in CAM usage among cancer patients. However, CAM use among medically underserved cancer patients remains to be well characterized. We evaluated CAM awareness as well as prevalence and characteristics of CAM use in 170 consecutive, medically underserved cancer patients presenting to a large, academic, inner-city cancer clinic, using a survey tool. Fifty-three participants declined participation and 17 survey results were incomplete. Therefore, 100 survey results were included in the final analysis. There were 65 males and 35 females in the survey with a mean age of 64.2 years. About 98% of the respondents were African American while 2% identified themselves as Hispanic. About 45% of patients had metastatic cancer, 24% had early-stage disease while 31% of patients were not aware of the stage of their cancer. About 55% patients had elementary school or lower level of education while only 16% had a college degree or higher. About 92% of respondents were unemployed. Some knowledge of CAM was reported by 22% of patients, while CAM use was reported in only 16% of patients. Female sex and college degree were significantly associated with CAM use. The most commonly used CAM modality was meditation (56%), followed by herbal remedies (31%), yoga (31%), and acupuncture (12%). Among CAM users, a majority used multiple CAM therapies. All users reported benefit from CAM use. Emotional wellbeing was the most common benefit followed by improvement in treatment related adverse effects, chemotherapy related symptoms, pain, and sleep. Even though the majority of our surveyed patients never used CAM, 90% of non-users were interested in gaining more information about the various CAM options and exploring its use and potential benefits. The majority (70%) wanted their primary oncologist to provide information about CAM options and discuss its safety and potential complementary benefit in management of their cancer and associated symptoms.
Patient Education for Radical Prostatectomy: Development of a Program Tailored to the Needs of Prostate Cancer Patients
Authors: Terrier Jean-Etienne , Ruffion Alain , Hamant Chloé , Rousset Vanessa , Kalecinski Julie , Baudot Amandine , Dumas Agnes , Chauvin Franck , Bourmaud Aurelie
Published: December 2021

In all, 30% to 90% of prostate cancer patients undergoing radical prostatectomy (RP) recover their erectile capacity. No effective post RP erectile rehabilitation program exists to date. The aim of this exploratory qualitative study is to explore the needs of these patients and to develop a patient education program (PEP) which meets these needs. Interviews were carried out by a socio-anthropologist with prostate cancer patients treated by RP within the 6 previous months. The needs and expectations identified led to the choice of a logical model of change for the construction of the PEP. Nineteen patients were included in the study; 17 of them were living with a partner. Two categories of patients appeared during the interviews: informed patients resigned to lose their sexuality and patients misinformed about the consequences of the surgery. The tailored program was built on the Health Belief Model and provides six individual sessions, including one with the partner, to meet the needs identified. This study designed the first program to target comprehensively the overall sexuality of the patient and his partner, and not only erection issues. To demonstrate the effectiveness of this program, a controlled, multicentric clinical trial is currently ongoing.
How to improve the Triage: A dashboard to assess the quality of nurses’ decision-making
Authors: Cannavacciuolo Lorella , Ponsiglione Cristina , D’Ambrosio Antonio
Published: December 2021

This paper presents a dashboard for assessing the quality of Triage decision-making process in the assignment of the priority code to patients arriving at an emergency department. The quality is assessed through performance indexes aimed at measuring both the nurses’ accuracy and the presence of nurses’ shared behavior in the Triage assignment process. The theoretical perspective of the cognitive heuristic, that is a cognitive shortcut strategy to make decisions, is the framework to design performance indexes of the dashboard. The dashboard has been tested in two Emergency Departments. We gather the data input through the submission to 54 nurses of a questionnaire, simulating 25 patients’ scenarios. The dashboard reveals a disparity between nurses in priority level assignment. This disparity depends on nurses’ capacity in disregarding some information and in considering the right cue. We find the presence of sharing behaviors and inclination to over or under assessment by nurses. This performance analysis, integrated with the nurses’ reasoning in assigning the priority code, can address the management in designing improvement actions at individual level and at the organizational one. In addition, the application to two Emergency Department confirms the influence of organizational aspects in the individual decision process.
Age Differences in Online News Consumption and Online Political Expression in the United States, United Kingdom, and France
Authors: Boulianne Shelley , Shehata Adam
Published: December 2021

Younger and older generations are differently motivated in relation to news consumption and online political expression. In this paper, we suggest that different modes of citizenship characterize younger and older generations. To test the differential role of political interest in news consumption and online political expression, we use a survey of 3,210 people from the United States, 3,043 from the United Kingdom, and 3,031 from France. Our findings suggest that young citizens are more frequent users of online news overall and that the rank order of different news activities replicates cross-nationally. The frequency of online political expression is negatively related to age, with older people less likely to post online. Age moderates the relationship between political interest and news consumption as well as news consumption and online political expression. The correlations of these sets of variables are stronger for younger respondents compared to older respondents. These findings hold across the three countries under study. We explain these patterns in terms of changing citizenship norms and discuss the implications for democracy.
Anterior Cruciate Ligament Reconstruction versus Nonoperative Treatment: Better Function and Less Secondary Meniscectomies But No Difference in Knee Osteoarthritis—A Meta-Analysis
Authors: Cuzzolin Marco , Previtali Davide , Zaffagnini Stefano , Deabate Luca , Candrian Christian , Filardo Giuseppe
Published: December 2021

Objectives

The impact of anterior cruciate ligament (ACL) reconstruction on knee osteoarthritis (OA) is still unclear. The aim of the current meta-analysis was to compare surgical treatment versus nonoperative management of ACL tears to assess the impact of these approaches on knee OA development at a 5 and 10 years of follow-up.

Design

A meta-analysis was performed after a systematic literature search (May 2021) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Both randomized and nonrandomized comparative studies with more than 5 years of follow-up were selected. Influence of the treatment was assessed in terms of knee OA development, subjective and objective clinical results, activity level, and risk of further surgeries. Risk of bias and quality of evidence were assessed following the Cochrane guidelines.

Results

Twelve studies matched the inclusion criteria, for a total of 1,004 patients. Level of evidence was rated low to very low. No difference was documented in terms of knee OA development, Tegner score, subjective International Knee Documentation Committee (IKDC), and Lysholm scores. A significant difference favoring the surgical treatment in comparison with a nonsurgical approach was observed in terms of objective IKDC score ( P = 0.03) and risk of secondary meniscectomy ( P < 0.0001). The level of evidence was considered very low for subjective IKDC, low for knee OA development, objective IKDC, number of secondary meniscectomies, and Lysholm score, and moderate for post-op Tegner score.

Conclusions

The meta-analysis did not support an advantage of ACL reconstruction in terms of OA prevention in comparison with a nonoperative treatment. Moreover, no differences were reported for subjective results and activity level at 5 and 10 years of follow-up. On the contrary, patients who underwent surgical treatment of their ACL tear presented important clinical findings in terms of better objective knee function and a lower rate of secondary meniscectomies when compared with conservatively managed patents. Protocol Registration: CRD420191156483 (PROSPERO)
Diosmetin attenuate experimental ulcerative colitis in rats via suppression of NF-κB, TNF-α and IL-6 signalling pathways correlated with down-regulation of apoptotic events
Authors: Yu Xiaoyan , Liu Yang
Published: December 2021

Introduction

Ulcerative colitis (UC) is a chronic inflammation of colon in which the innermost tissue of colon and rectum develops deep-rooted inflammation. Diosmetin is the aglycone of the flavonoid glycoside diosmin, commonly found in citrus fruits. Therapeutically diosmetin is indicated to demonstrate anticancer, antimicrobial, antioxidant, oestrogenic and anti-inflammatory activity.

Methods

In this research, we studied the action of diosmetin on TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced UC in rats. Male Wister rats were anesthetised with pentobarbital and TNBS introduced by performing an enema. Diosmetin treatment was provided through oral gavage for the next 28 days. Animals were sacrificed on the 29th day and colon tissues were collected for further examinations.

Results

Diosmetin treatment decreased colonic ulceration dramatically and decreased the percentage of inflammation in the colonic mucosa. Depletion of the TNBS assisted of superoxide dismutase and catalase was substantially restricted, while lipid peroxidation was recorded in the colonic tissue as malondialdehyde content was also decreased. After treatment with diosmetin, the occurrence of TNF-α, IL-6and NF-κB was considerably lowered and the number of apoptotic cells observed was significantly reduced.

Conclusion

Taken together, these observations demonstrated the potential of diosmetin against ulcer formation and development.
Rethinking Leisure Tourism: From the Perspective of Tourist Touch Points and Perceived Well-being
Authors: Chen Chang , Teng Zhuoqi , Lu Chunyi , Hossain Md. Alamgir , Fang Yuantao
Published: December 2021

The current study empirically examines an integrative model linking multiple types of touch points in tourism experience, hedonic well-being, eudaimonic well-being, revisit intention, and online word of mouth, in response to the calls to revitalize tourism and achieve sustainable development. The research relied on “Nong Jia Le,” an important representative survey on leisure tourism. The questionnaire was developed based on prior studies, then translated into Chinese and set up in an online survey system. In total, 316 respondents were ultimately gathered for analysis. Principal component analysis was used to test the reliability and validity of each construct, and a structural equation model was used to test the hypotheses. The findings show that tourism experiences derived from partner-owned, customer-owned, and social touch points positively affect perceived hedonic and eudaimonic well-being, while experiences derived from destination-owned touch points only positively influence hedonic well-being. In addition, both hedonic and eudaimonic well-being significantly affect consumers’ intention to revisit the destination and to spread word of mouth online. This study fills in a gap in leisure tourism literature by proposing the merits of touch points in tourism experience and placing importance on conceptions of eudaimonia. More importantly, the current research offers important social and economic considerations that can contribute to the sustainable growth of leisure tourism.
Connecting Corporate Social Responsibility (CSR) to Customer Loyalty: A Mediation Analysis in Hoteling Industry of Pakistan
Authors: Shah Muhammad Usman , Jan Muhammad Farooq
Published: December 2021

This study examines the role of Corporate Social Responsibility (CSR) in enhancing customer loyalty by exploring direct and mediating effects of trust, credibility, and word of mouth. Cross-sectional data of 463 respondents was taken from Pakistan using an online survey because of the limitations of covid19. Hypotheses were tested using SmartPLS-3. Findings of the study revealed that CSR has affected customer loyalty significantly and positively. The mediating role of trust was found insignificant. Credibility and word of mouth were found as significant mediating variables in the linkage between CSR and Customer Loyalty. This study has provided a direction for the hoteling industry to incorporate CSR activities in their operation for gaining customer loyalty using empirical analysis. In this regard, this paper makes a significant contribution to the existing literature regarding the connections between CSR and customer loyalty with the help of trust, credibility, and word of mouth as mediators, which are not tested empirically in the existing literature.
Application of AHP in Aerospace Configuration Management
Authors: Suresh Kumar C.  , Pillai Sini V. , Subramoniam Suresh
Published: December 2021

Aerospace products undergo frequent modifications throughout their product life cycle due to changes in requirements, technology, policy or environmental concerns. These modifications/changes are dealt with through configuration management (CM), which is a techno-managerial function. Conflicting interests of teams involved, complexity due to a long product life cycle spanning over years, R&D nature and techno-political compromises often end up in sub-optimal decisions during aerospace product development. In this article, an attempt is made to apply a scientific method to CM decision-making rather than leave it to techno-political compromises. The CM decision-making is modelled as a multi-criteria decision-making (MCDM) problem and is solved using analytic hierarchy process (AHP). As an example, the CM change proposal on propellant tank material in aerospace is taken up and solved using the model. The authors believe that results of the study will also pave way for substitute development with improved attributes, realized through advances in technologies such as nanotechnology and additive manufacturing, as mentioned in directions for future research.