RELATIONSHIP BETWEEN THE SERUM BILIRUBIN LEVEL AND THE SPIROMETRIC PARAMETERS IN ADOLESCENTS WITH BRONCHIAL ASTHMA. A PILOT STUDY
Authors:   Nizhny Novgorod City Children’s Clinical Hospital No. 1, Nizhny Novgorod, Russia, Boriskina O.S. , Eliseeva T.I. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Tush E.V. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Khramova R.N. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Soodaeva S.K. ,   Research Institute for Pulmonology of the Russian Federal Biomedical Agency, Moscow, Russia, Ovsyannikov D.Yu. ,   Patrice Émery Lumumba People’s Friendship University of Russia, Moscow, Russia, Pavlova E.V. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Isharina A.N. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Kubysheva N.I. ,   Kazan and the Volga Region Federal University, Kazan, Republic of Tatarstan, Russia, Khaletskaya O.V. ,   Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia, Novikov D.V. ,   Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology with the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Nizhny Novgorod, Russia, Novikov V.V. ,   Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology with the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Nizhny Novgorod, Russia
Published: October 2023

Purpose of the research was to study the relationship between the serum bilirubin level and the spirometric parameters in adolescents with bronchial asthma (BA). Materials and methods used: 213 patients (73,7% boys) with atopic BA aged 10 to 17 y/o were examined. All patients underwent determination of serum bilirubin level, spirometry indicators and general clinical examination. All patients were divided into three groups: G1 of 84 with reduced bilirubin level (less than 10 mсmol/l); G2 of 77 with normal bilirubin level (10 to 17,0 mсmol/l); and G3 of children with slightly elevated bilirubin level (17,1 to 45 mсmol/l). Results: elevated serum bilirubin level in this study occurred in 24.4% (52/213) of patients with BA. As the level of serum bilirubin increased in the general group of patients, a statistically significant increase in the z-criterion of the forced expiratory volume per 1 second (FEV1)/forced vital capacity (FVC) (p=0,005) and the z-criterion of the mean forced expiratory flow during the 25-75% of FVC (p=0,032) was observed, which was confirmed by the revealed positive correlations between the level of bilirubin and these spirometric indicators. The increase in z-criterion FEV1/FVC with an increase in bilirubin levels was statically significant in boys (p=0,046), in girls there was only a tendency to increase this indicator (p=0,07). Conclusion: bronchial patency in patients with slightly elevated bilirubin levels is higher than in patients with reduced serum bilirubin level in the blood. The best characteristics of bronchial patency in patients with “slightly elevated” bilirubin level suggest its protective effect in children with BA.