bluuebunny/crossref_metadata_2025 huggingface dataset:
Analytical solution for acoustic radiation force on a sphere near a planar boundary
Authors: Simon Blake E. , Hamilton Mark F.
Published: January 2023

Acoustic radiation force on a sphere in an inviscid fluid near a planar boundary, which may be rigid or pressure release, is calculated using spherical wave functions to expand the total pressure field. The condition at the boundary is satisfied with the addition of a reflected wave and an image sphere. The total pressure field, which is exact in the linear approximation, is composed of the incident field, the reflected field, and the scattered fields due to the physical sphere and the image sphere. The expansion coefficients for the pressure field are used to evaluate the acoustic radiation force on the sphere using a known analytical expression obtained from integration of the radiation stress tensor. Calculations illustrate the influence of multiple scattering effects on the radiation force acting on the sphere. The model applies to compressible and elastic spheres and for any incident field structure. An approximation is introduced that extends the analytical model to other types of interfaces, including a fluid-fluid interface. The analytical model is validated by comparisons with an independent finite element model.
Effect of nodule size and stiffness on phonation threshold and collision pressures in a synthetic hemilaryngeal vocal fold model
Authors: Motie-Shirazi Mohsen , Zañartu Matías , Peterson Sean D. , Mehta Daryush D. , Hillman Robert E. , Erath Byron D.
Published: January 2023

Synthetic vocal fold (VF) replicas were used to explore the role of nodule size and stiffness on kinematic, aerodynamic, and acoustic measures of voiced speech production. Emphasis was placed on determining how changes in collision pressure may contribute to the development of phonotrauma. This was performed by adding spherical beads with different sizes and moduli of elasticity at the middle of the medial surface of synthetic silicone VF models, representing nodules of varying size and stiffness. The VF models were incorporated into a hemilaryngeal flow facility. For each case, self-sustained oscillations were investigated at the phonation threshold pressure. It was found that increasing the nodule diameter increased the open quotient, phonation threshold pressure, and phonation threshold flow rate. However, these values did not change considerably as a function of the modulus of elasticity of the nodule. Nevertheless, the ratio of collision pressure to subglottal pressure increased significantly for both increasing nodule size and stiffness. This suggests that over time, both growth in size and fibrosis of nodules will lead to an increasing cycle of compensatory vocal hyperfunction that accelerates phonotrauma.
Graph-guided Bayesian matrix completion for ocean sound speed field reconstruction
Authors: Li Siyuan , Cheng Lei , Zhang Ting , Zhao Hangfang , Li Jianlong
Published: January 2023

Reconstructing ocean sound speed field (SSF) from limited and noisy measurements/estimates is crucial for many ocean acoustic applications, including underwater tomography, target localization/tracking, and communications. Classical reconstruction methods include deterministic approaches (e.g., spline interpolation) and geostatistical methods (e.g., kriging). They exhibit a strong link to linear regression and Gaussian process regression in machine learning (ML) literature, by uniformly viewing them as supervised regression models that learn the mapping from the geographical locations to the sound speed outputs. From a unified ML perspective, theoretical analysis indicates that classical reconstruction methods have several drawbacks, such as the sensitivity to noises and high computational cost. To overcome these drawbacks, inspired by the recent thriving development of graph machine learning, we introduce graph-guided Bayesian low-rank matrix completions (LRMCs) for fine-scale and accurate ocean SSF reconstruction. In particular, a more general graph-guided LRMC model is proposed that encompasses the state-of-the-art one as a special case. The proposed model and the associated inference algorithm simultaneously exploit the global (low-rankness) and local (graph structure) information of ocean sound speed data, thus striking an outstanding balance of reconstruction accuracy and computational complexity. Numerical results using real-life ocean SSF data have demonstrated the encouraging performances of the proposed approaches.
Under the Influence: Marijuana, the Black Male Athlete, and Alternative Understandings of Humanity
Authors: Dickerson Nik
Published: January 2023

This paper analyzes a series of advertisements from the antidrug campaign Above the Influence and interviews of former National Football League and National Basketball Association players by the website Bleacher Report regarding their marijuana use. Guided by Christina Sharpe’s theoretical concept of the “wake,” I argue that the Above the Influence adverts produce a trope I call Chronic Black male sporting hood. A trope that holds the Black body in a state of dehumanization. The second half of this paper utilizes Sharpe’s Black methodological tool of Black annotation/redaction. Through this Black methodological tool, the testimonial of the athletes, and the influences of Black musicians, I argue that these athletes provide insight into alternative ways of living and being human that arise from the anti-Black practices of sport with marijuana serving as their catalyst.
Encouraging Togetherness During a National Lockdown: The Influence of Relationship-Oriented Personal-Disclosure Mutual-Sharing on Team Functioning in Academy Soccer Coaches
Authors: Warburton Harry K. , Slater Matthew J.
Published: January 2023

The present study examined the influence of an online relationship-oriented personal-disclosure mutual-sharing (ROPDMS) intervention upon diverse measures of group functioning during a national lockdown. Twelve soccer coaches and one senior member of staff from a professional female soccer academy participated by openly disclosing and sharing unknown personal stories with one another. Social identity dimensions (in-group ties, cognitive centrality, and in-group affect), friendship identity content, social support, self-esteem, and a nonequivalent dependent variable were measured across four time points, while social validation was obtained immediately and 4 weeks after ROPDMS. Quantitative data revealed significant increases for in-group ties, cognitive centrality, and friendship identity content after ROPDMS, while the nonequivalent dependent variable did not significantly change. Qualitative data revealed that the coaching staff felt the session was worthwhile and enhanced aspects of team functioning. Online ROPDMS therefore appears to be a viable team-building method for practitioners seeking to strengthen social identity dimensions and friendship identity content during a national lockdown.
SUMOylation-mediated PSME3-20
S
proteasomal degradation of transcription factor CP2c is crucial for cell cycle progression
Authors: Son Seung Han , Kim Min Young , Lim Young Su , Jin Hyeon Cheol , Shin June Ho , Yi Jae Kyu , Choi Sungwoo , Park Mi Ae , Chae Ji Hyung , Kang Ho Chul , Lee Young Jin , Uversky Vladimir N. , Kim Chul Geun
Published: January 2023

Transcription factor CP2c (also known as TFCP2, α-CP2, LSF, and LBP-1c) is involved in diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies such as cancer. Despite its importance, many fundamental regulatory mechanisms of CP2c are still unclear. Here, we uncover an unprecedented mechanism of CP2c degradation via a previously unidentified SUMO1/PSME3/20
S
proteasome pathway and its biological meaning. CP2c is SUMOylated in a SUMO1-dependent way, and SUMOylated CP2c is degraded through the ubiquitin-independent PSME3 (also known as REGγ or PA28)/20
S
proteasome system. SUMOylated PSME3 could also interact with CP2c to degrade CP2c via the 20
S
proteasomal pathway. Moreover, precisely timed degradation of CP2c via the SUMO1/PSME3/20
S
proteasome axis is required for accurate progression of the cell cycle. Therefore, we reveal a unique SUMO1-mediated uncanonical 20
S
proteasome degradation mechanism via the SUMO1/PSME3 axis involving mutual SUMO-SIM interaction of CP2c and PSME3, providing previously unidentified mechanistic insights into the roles of dynamic degradation of CP2c in cell cycle progression.
A 6G meta-device for 3D varifocal
Authors: Zhang Jing Cheng , Wu Geng-Bo , Chen Mu Ku , Liu Xiaoyuan , Chan Ka Fai , Tsai Din Ping , Chan Chi Hou
Published: January 2023

The sixth-generation (6G) communication technology is being developed in full swing and is expected to be faster and better than the fifth generation. The precise information transfer directivity and the concentration of signal strength are the key topics of 6G technology. We report the synthetic phase design of rotary doublet Airy beam and triplet Gaussian beam varifocal meta-devices to fully control the terahertz beam’s propagation direction and coverage area. The focusing spot can be delivered to arbitrary positions in a two-dimensional plane or a three-dimensional space. The highly concentrated signal can be delivered to a specific position, and the transmission direction can be adjusted freely to enable secure, flexible, and high-directivity 6G communication systems. This technology avoids the high costs associated with extensive use of active components. 6G communication systems, wireless power transfer, zoom imaging, and remote sensing will benefit from large-scale adoption of such a technology.
Thermal history modeling techniques and interpretation strategies: Applications using QTQt
Authors: Abbey Alyssa L. , Wildman Mark , Stevens Goddard Andrea L. , Murray Kendra E.
Published: January 2023

Advances in low-temperature thermochronology have made it applicable to a plethora of geoscience investigations. The development of modeling programs (e.g., QTQt and HeFTy) that extract thermal histories from thermochronologic data has facilitated growth of this field. However, the increasingly wide range of scientists who apply these tools requires an accessible entry point to thermal history modeling and how these models develop our understanding of complex geological processes. This contribution offers a discussion of modeling strategies, using QTQt, including making decisions about model design, data input, kinetic parameters, and other factors that may influence the model output. We present a suite of synthetic data sets derived from known thermal histories with accompanying tutorial exercises in the Supplemental Material1. These data sets illustrate the opportunities and limitations of thermal history modeling. Examining these synthetic data helps to develop intuition about which thermochronometric data are most sensitive to different thermal events and to what extent user decisions on data handling and model setup can control the recovery of the true solution. We also use real data to demonstrate the importance of incorporating sensitivity testing into thermal history modeling and suggest several best practices for exploring model sensitivity to factors including, but not limited to, the model design or inversion algorithm, geologic constraints, data trends, the spatial relationship between samples, or the choice of kinetics model. Finally, we provide a detailed and explicit workflow and an applied example for a method of interrogating vague model results or low observation-prediction fits that we call the “Path Structure Approach.” Our explicit examination of thermal history modeling practices is designed to guide modelers to identify the factors controlling model results and demonstrate reproducible approaches for the interpretation of thermal histories.
Pancreaticobiliary versus head and neck presentation of immunoglobulin G4-related disease: different sides of the same coin?
Authors: Awadelkarim Bidour , Vila Josephine , Nayar Manu K , Leeds John S , Griffiths Bridget , Oppong Kofi W
Published: January 2023

Background and study aim

Immunoglobulin G4-related disease (IgG4-RD) is a rare immune mediated fibroinflammatory condition. Pancreaticobiliary (PB) and head and neck (HN) are two of the most commonly involved anatomical sites. It has been postulated that PB IgG4-RD and HN IgG4-RD have distinct clinical phenotypes. Whether the optimum treatment regimen or response to therapy differs between them is unknown. We aimed to assess differences between PB and HN IgG4-RD in a cohort of IgG4 disease managed by an IgG4-RD multispecialty team.

Methods

We performed a retrospective study of a prospectively maintained multidisciplinary IgG4-RD database to identify patients diagnosed with PB and HN IgG4-RD (based on initial presentation) between 2005 and 2019. The electronic patient records were reviewed. Use of immunosuppressive agents and clinical course was analysed.

Results

60 patients with PB IgG4-RD and 14 with HN IgG4-RD were included in the study. PB IgG4-RD was associated with older age at diagnosis 64 versus 51 years (p<0.001), higher serum IgG4 level as a multiple of upper limit of normal median (IQR) 2 (1–3.75) vs 1 (1–2), (p=0.04) and greater proportion with more than one organ involved 68% vs 33% (p=0.03). HN IgG4-RD was more likely to receive second-line therapy 71% versus 36% (p=0.03). Persistent elevation of serum IgG4 after therapy was more common in PB IgG4-RD 84% versus 43% (p=0.03).

Conclusion

These findings support the contention that PB IgG4-RD and HN IgG4-RD have different clinical profiles and represent distinct subtypes of IgG4-RD.
One health systems strengthening in countries: Tripartite tools and approaches at the human-animal-environment interface
Authors: de la Rocque Stephane , Errecaborde Kaylee Marie Myhre , Belot Guillaume , Brand Tianna , Shadomy Sean , von Dobschuetz Sophie , Aguanno Ryan , Carron Maud , Caya Francois , Ding Shanlong , Dhingra Madhur , Donachie Daniel , Gongal Gyanendra , Hoejskov Peter , Ismayilova Gunel , Lamielle Gael , Mahrous Heba , Marrana Mariana , Nzietchueng Serge , Oh Yooni , Pinto Julio , Roche Xavier , Riviere-Cinnamond Ana , Rojo Cristina , Scheuermann Lisa , Sinclair Julie , Song Junxia , Skrypnyk Artem , Traore Tieble , Wongsathapornchai Kachen
Published: January 2023

Unexpected pathogen transmission between animals, humans and their shared environments can impact all aspects of society. The Tripartite organisations—the Food and Agriculture Organization of the United Nations (FAO), the World Health Organization (WHO), and the World Organisation for Animal Health (WOAH)—have been collaborating for over two decades. The inclusion of the United Nations Environment Program (UNEP) with the Tripartite, forming the ‘Quadripartite’ in 2021, creates a new and important avenue to engage environment sectors in the development of additional tools and resources for One Health coordination and improved health security globally. Beginning formally in 2010, the Tripartite set out strategic directions for the coordination of global activities to address health risks at the human-animal-environment interface. This paper highlights the historical background of this collaboration in the specific area of health security, using country examples to demonstrate lessons learnt and the evolution and pairing of Tripartite programmes and processes to jointly develop and deliver capacity strengthening tools to countries and strengthen performance for iterative evaluations. Evaluation frameworks, such as the International Health Regulations (IHR) Monitoring and Evaluation Framework, the WOAH Performance of Veterinary Services (PVS) Pathway and the FAO multisectoral evaluation tools for epidemiology and surveillance, support a shared global vision for health security, ultimately serving to inform decision making and provide a systematic approach for improved One Health capacity strengthening in countries. Supported by the IHR-PVS National Bridging Workshops and the development of the Tripartite Zoonoses Guide and related operational tools, the Tripartite and now Quadripartite, are working alongside countries to address critical gaps at the human-animal-environment interface.
Implementing health system improvement: resources and strategies for interprofessional teams
Authors: Eljiz Kathy , Greenfield David , Hogden Anne , Agaliotis Maria , Taylor Robyn , Siddiqui Nazlee
Published: January 2023

Health system improvement (HSI) is focused on systematic changes to organisational processes and practices to improve the efficient delivery of safe care and quality outcomes. Guidelines that specify how interprofessional teams conduct HSI and knowledge translation are needed. We address this urgent requirement providing health professional teams with resources and strategies to investigate, analyse and implement system-level improvements. HSI encompasses similar, yet different, inter-related activities across a continuum. The continuum spans three categories of activities, such as quality improvement, health management research and translational health management research. A HSI decision making guide and checklist, comprising six-steps, is presented that can be used to select and plan projects. This resource comprises six interconnected steps including, defining the activity, project outcome, aim, use of evidence, appropriate methodology and implementation plan. Each step has been developed focusing on an objective, actions and resources. HSI activities provide a foundation for interprofessional collaboration, allowing multiple professions to create, share and disseminate knowledge for improved healthcare. When planned and executed well, HSI projects assist clinical and corporate staff to make evidence-informed decisions and directions for the benefit of the service, organisation and sector.
Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study
Authors: Garcia-Rio Francisco , Miravitlles Marc , Soriano Joan B , Cosío Borja G , Soler-Cataluña Juan José , Casanova Ciro , de Lucas Pilar , Alfageme Inmaculada , Rodríguez González-Moro José Miguel , Sánchez Herrero María Guadalupe , Ancochea Julio
Published: January 2023

Background

Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.

Methods

A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.

Results

In never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO.

Conclusion

Reduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.

Trial registration number

NCT03028207.
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Authors: Conche Claire , Finkelmeier Fabian , Pešić Marina , Nicolas Adele M , Böttger Tim W , Kennel Kilian B , Denk Dominic , Ceteci Fatih , Mohs Kathleen , Engel Esther , Canli Özge , Dabiri Yasamin , Peiffer Kai-Henrik , Zeuzem Stefan , Salinas Gabriela , Longerich Thomas , Yang Huan , Greten Florian R
Published: January 2023

Objective

Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment.

Design

Glutathione peroxidase 4 (GPx4), which is considered the master regulator of ferroptosis, was genetically altered in murine models for hepatocellular carcinoma (HCC) and colorectal cancer (CRC) to analyse the effect of ferroptosis on tumour cells and the immune tumour microenvironment. The findings served as foundation for the identification of additional targets for combine therapy with ferroptotic inducer in the treatment of HCC and liver metastasis.

Results

Surprisingly, hepatocyte-restricted GPx4 loss does not suppress hepatocellular tumourigenesis. Instead, GPx4-associated ferroptotic hepatocyte death causes a tumour suppressive immune response characterised by a CXCL10-dependent infiltration of cytotoxic CD8+T cells that is counterbalanced by PD-L1 upregulation on tumour cells as well as by a marked HMGB1-mediated myeloid derived suppressor cell (MDSC) infiltration. Blocking PD-1 or HMGB1 unleashes T cell activation and prolongs survival of mice withGpx4-deficient liver tumours. A triple combination of the ferroptosis inducing natural compound withaferin A, the CXCR2 inhibitor SB225002 and α-PD-1 greatly improves survival of wild-type mice with liver tumours. In contrast, the same combination does not affect tumour growth of subcutaneously grown CRC organoids, while it decreases their metastatic growth in liver.

Conclusion

Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases.
Short-term effect of colorectal cancer on income: analysis of an Italian cohort
Authors: Farina Elena , Rosso Marco , Dansero Lucia , Ippoliti Roberto , Numico Gianmauro , Macciotta Alessandra , Bena Antonella , Ricceri Fulvio
Published: January 2023

Introduction

The ability to return to work after a cancer diagnosis is a key aspect of cancer survivorship and quality of life. Studies have reported a significant risk of income loss for cancer survivors; however, there is limited evidence of the Italian context.

Methods

The Work Histories Italian Panel (WHIP)-Salute database was used to select a cohort of incident cases of colorectal cancer (CRC) among workers in the private sector, based on hospital discharges. A propensity score matching was used to find a balanced control group for several confounders. Ordinary least square and logistic regressions were used to estimate the effect of a CRC diagnosis on annual income and the probability of switching from a full-time contract to a part-time one considering 3 years after the diagnosis.

Results

Overall, we identified 925 CRC incident cases from 2006 until 2012. Our results confirm a statistically significant reduction in survivors’ income compared with controls. This reduction was greater in the first year and then tend to decrease, with an average income loss over 3 years of about €12 000. Stratified analyses by sex and position confirmed the overall trend while indicating a strong effect modification. Regarding the switching from full-time to part-time employment, the results were never significant.

Conclusion

Income loss does not seem to be related to an increase in part-time contracts, but rather to survivors’ reduced work capacity following the invasive treatments. Further research is needed to investigate the complex dynamics behind this association.
Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians
Authors: Chen Yian , Wang Eric , Sites Brian D , Cohen Steven P
Published: January 2023

Chronic pain begins with acute pain. Physicians tend to classify pain by duration (acute vs chronic) and mechanism (nociceptive, neuropathic and nociplastic). Although this taxonomy may facilitate diagnosis and documentation, such categories are to some degree arbitrary constructs, with significant overlap in terms of mechanisms and treatments. In clinical practice, there are myriad different definitions for chronic pain and a substantial portion of chronic pain involves mixed phenotypes. Classification of pain based on acuity and mechanisms informs management at all levels and constitutes a critical part of guidelines and treatment for chronic pain care. Yet specialty care is often siloed, with advances in understanding lagging years behind in some areas in which these developments should be at the forefront of clinical practice. For example, in perioperative pain management, enhanced recovery protocols are not standardized and tend to drive treatment without consideration of mechanisms, which in many cases may be incongruent with personalized medicine and mechanism-based treatment. In this educational document, we discuss mechanisms and classification of pain as it pertains to commonly performed surgical procedures. Our goal is to provide a clinical reference for the acute pain physician to facilitate pain management decision-making (both diagnosis and therapy) in the perioperative period.
A Study on How Food Colour May Determine the Categorization of a Dish: Predicting Meal Appeal from Colour Combinations
Authors: Casales-Garcia V. , Falomir Z. , Museros Ll. , Sanz I. , Gonzalez-Abril L.
Published: January 2023

A person’s preference to select or reject certain meals is influenced by several aspects, including colour. In this paper, we study the relevance of food colour for such preferences. To this end, a set of images of meals is processed by an automatic method that associates mood adjectives that capture such meal preferences. These adjectives are obtained by analyzing the colour palettes in the image, using a method based in Kobayashi’s model of harmonic colour combinations. The paper also validates that the colour palettes calculated for each image are harmonic by developing a rating model to predict how much a user would like the colour palettes obtained. This rating is computed using a regression model based on the COLOURlovers dataset implemented to learn users’ preferences. Finally, the adjectives associated automatically with images of dishes are validated by a survey which was responded by 178 people and demonstrates that the labels are adequate. The results obtained in this paper have applications in tourism marketing, to help in the design of marketing multimedia material, especially for promoting restaurants and gastronomic destinations.
Rivers, streams and wetlands – the Chalk and its water-dependent ecosystems
Authors: Wetherell Anna
Published: January 2023

The UK, and England in particular, is the stronghold for chalk rivers, streams and wetlands in Europe. A number of sites are recognized as being important for nature conservation and have been designated as such under UK and European legislation. However, as the chalk is also an important aquifer for southern and eastern England, there have been significant impacts on these groundwater-dependent ecosystems from abstraction. Chalk rivers and streams have been used for centuries for mills and water meadows, so impacts have not just occurred in recent times. Intensification of agriculture in the twentieth century has added to the pressure by increasing levels of pollution, especially nitrates, with significant levels now being recorded. However, moves have been made to resolve some of these issues, with investigations into the effects of abstraction and options for reducing these impacts, research into the nature of the chalk aquifer so that it can be modelled more accurately, and assessment made of pollution pathways and their timescales. Associated projects have characterized the ecosystems associated with the chalk in more detail, enabling the mechanism for impacts to be better understood. While the extent of impacts is increasingly understood, action is also being taken to reduce their effects and restore chalk ecosystems.
Report on the Workshop on Personal Knowledge Graphs (PKG 2021) at AKBC 2021
Authors: Balog Krisztian , Mirza Paramita , Skjæveland Martin G. , Wang Zhilin
Published: January 2023

The term
personal knowledge graph
(PKG) has been broadly used to refer to structured representation of information about a given user, primarily in the form of entities that are personally related to the user. The potential of personal knowledge graphs as a means of managing and organizing personal data, as well as a source of background knowledge for personalizing downstream services, has recently gained increasing attention from researchers in multiple fields, including that of Information Retrieval, Natural Language Processing, and the Semantic Web. The goal of the PKG'21 workshop was to create a forum for researchers and practitioners from diverse areas to present and discuss methods, tools, techniques, and experiences related to the construction and use of personal knowledge graphs, identify open questions, and create a shared research agenda. It successfully brought about a diverse workshop program, comprising an invited keynote, paper presentations, and breakout discussions, as a half-day event at the 3rd Automated Knowledge Base Construction (AKBC'21) conference. The workshop demonstrated that while the concept and research field of personal knowledge graphs is still in its early stages, there are many promising avenues of future development and research that already, and independently, have attracted the interest of several different communities.

Date:
October 8, 2021.

Website:
https://pkgs.ws.
SGLT2 Inhibitors: The Sweet Success for Kidneys
Authors: Dharia Atit , Khan Abid , Sridhar Vikas S. , Cherney David Z.I.
Published: January 2023

Sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) were originally developed as antidiabetic agents, with cardiovascular (CV) outcome trials demonstrating improved CV outcomes in patients with type 2 diabetes mellitus (T2D). Secondary analyses of CV outcome trials and later dedicated kidney outcome trials consistently reported improved kidney-related outcomes independent of T2D status and across a range of kidney function and albuminuria. Importantly, SGLT2 inhibitors are generally safe and well tolerated, with clinical trials and real-world analyses demonstrating a decrease in the risk of acute kidney injury. The kidney protective effects of SGLT2 inhibitors generally extend across different members of the class, possibly on the basis of hemodynamic, metabolic, anti-inflammatory, and antifibrotic mechanisms. In this review, we summarize the effects of SGLT2 inhibitors on kidney outcomes in diverse patient populations.
Electrodeposition of Li-Ion Cathode Materials: The Fascinating Alternative for Li-Ion Micro-Batteries Fabrication
Authors: Behboudikhiavi Sepideh , Omale Joel Ojonugwa , Babu Binson , Piraux Luc , Vlad Alexandru
Published: January 2023

Li-ion microbatteries are the frontline candidates to fulfill the requirements of powering miniature autonomous devices. However, it still remains challenging to attain the required energy densities of > 0.3mWh cm−2
μm−1 in a planar configuration. To overcome this limitation, 3D architectures of LIMBs have been proposed. However, most deposition techniques are poorly compatible with 3D architectures because they limit the choice of current collectors and selective deposition of the active materials. Electrodeposition was suggested as an alternative for rapidly and reproducibly depositing active materials under mild conditions, and with controlled properties. However, despite the huge potential, electrodeposition remains underexplored for LIMB cathode materials, partly due to challenges associated with the electrodeposition of Li-ion phases. Herein, we review advances in the electrodeposition of Li-ion cathode materials with the main focus set on the direct, one-step deposition of electrochemically active phases. We highlight the merits of electrodeposition over other methods and discuss the various classes of reported materials, including layered transition metal oxides, vanadates, spinel, and olivines. We offer a perspective on the future advances for the adoption of electrodeposition processes for the fabrication of microbatteries to pave the way for future research on the electrodeposition of cathode materials.
Carotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids
Authors: Costa Tiago J. , Barros Paula R. , Duarte Diego A. , Silva-Neto Júlio A. , Hott Sara Cristina , Santos-Silva Thamyris , Costa-Neto Claudio M. , Gomes Felipe V. , Akamine Eliana H. , McCarthy Cameron G. , Jimenez-Altayó Francesc , Dantas Ana Paula , Tostes Rita C.
Published: January 2023

The present study provides evidence that senescence induces hyperreactivity of α1-adrenoceptor-mediated contraction of the common carotid. Impairment of α1-adrenoceptor responses is linked to increased Ca2+ influx and release of COX-derived vasoconstrictor prostanoids, contributing to carotid dysfunction in the murine model of female senescence (SAMP8). Increased reactivity of the common carotid artery during senescence may lead to morphological and functional changes in arteries of the cerebral microcirculation and contribute to cognitive decline in females. Because the elderly population is growing, elucidating the mechanisms of aging- and sex-associated vascular dysfunction is critical to better direct pharmacological and lifestyle interventions to prevent cardiovascular risk in both sexes.
lncRNA CRNDE Affects Th17/IL-17A and Inhibits Epithelial-Mesenchymal Transition in Lung Epithelial Cells Reducing Asthma Signs
Authors: Yuan Yu , He Yi , Wasti Binaya , Duan Wentao , Jia Jingsi , Chen Zhifeng , Xiang Xudong , Zeng Qingping
Published: January 2023

Background. Asthma treatment is difficult due to disease heterogeneity and comorbidities. In addition, the development of drugs targeting the underlying mechanisms of asthma remains slow. We planned to identify the most upregulated differentially expressed long noncoding RNA in asthma to explore its regulatory patterns and pathways in asthma. Methods. We sensitized mice using a mixture of ovalbumin, house dust mites, and lipopolysaccharide to establish an asthma mouse model. We also sensitized asthma cells with TGF-β1 in an in vitro model. We performed a microarray analysis to identify the lncRNA with the differential expression level in model mice. We applied hematoxylin and eosin and Masson’s trichrome stainings to mouse tissues to quantify the tissue damage extent. Next, we assess the levels of lncRNA CRNDE, miR-29a-3p, TGF-β1, MCL-1, E-cadherin, vimentin, and snail. We counted the percentages of Th17 cells using flow cytometry. Finally, we performed a dual-luciferase reporter assay to assess the association between lncRNA CRNDE and miR-29a-3p. Results. We successfully established asthma mouse/cell models and selected the lncRNA CRNDE for our study. Transfection of si-CRNDE reduced the degree of injury and inflammation in the mouse model and reversed the TGF-β1-induced epithelial-mesenchymal transition (EMT) in the cell model. Moreover, the E-cadherin level was upregulated, and the levels of IL-17A, vimentin, snail, and α-SMA were downregulated. We also discovered that lncRNA CRNDE negatively regulated miR-29a-3p and that this one in turn inhibited MCL-1 in mice. After lncRNA CRNDE expression downregulation, the level of miR-29a-3p was increased, and we detected reduced levels of MCL-1 and EMTs. Conclusions. lncRNA CRNDE expression downregulation led to reduced inflammation and reduced lung damage in mice with induced asthma, it inhibited the EMTs of lung epithelial cells via the miR-29a-3p/MCL-1 pathway, and it reduced the levels of Th17/IL-17A cells to reduce asthma signs.
Studying Pregnancy Outcome Risk in Patients with Systemic Lupus Erythematosus Based on Cluster Analysis
Authors: Bikdeli Arezou , Li Daqing , Malide Minati , Nouri Meysam , Sun Hongsheng , Yang Qingrui , Golsanami Naser , Liu Dongxia
Published: January 2023

Background. Pregnancy in systemic lupus erythematosus (SLE) patients is a challenge due to the potential maternal and fetal complications. Therefore, a multidisciplinary assessment of disease risk before and during pregnancy is essential to improve pregnancy outcomes. Objectives. Our purpose was to (i) define clusters of patients with similar history and laboratory features and determine the associative maternal and perinatal outcomes and (ii) evaluate the risk spectrum of maternal and perinatal outcomes of pregnancy in SLE patients, represented by our established risk‐assessment chart. Methods. Medical records of 119 patients in China were analyzed retrospectively. Significant variables with p < 0.05 were selected. The self‐organizing map was used for clustering the data based on historical background and laboratory features. Results. Clustering was conducted using 21 maternal and perinatal features. Five clusters were recognized, and their prominent maternal manifestations were as follows: cluster 1 (including 27.73% of all patients): preeclampsia and lupus nephritis; cluster 2 (22.69%): oligohydramnios, uterus scar, and femoral head necrosis; cluster 3 (13.45%): upper respiratory tract infection; cluster 4 (15.97%): premature membrane rupture; and cluster 5 (20.17%): no problem. Conclusion. Pregnancy outcomes in SLE women fell into three categories, namely high risk, moderate risk, and low risk. Present manifestations, besides the medical records, are a potential assessment means for better management of pregnant SLE patients.
LncRNA LINC01833 is a Prognostic Biomarker and Correlates with Immune Infiltrates in Patients with Lung Adenocarcinoma by Integrated Bioinformatics Analysis
Authors: Liu Wei , Wan Qiu , Zhou Enzhu , He Ping , Tang Lixin
Published: January 2023

Due to the absence of accurate tools for early detection and successful treatment, lung adenocarcinoma (LUAD) is one of the most aggressive tumors with high morbidity and mortality globally. It is absolutely necessary to investigate the process behind its development and search for new biomarkers that could aid in the early detection of LUAD. There is a correlation between the immune microenvironment of the tumor and the prognosis of lung cancer as well as the efficacy of immunotherapy. Long noncoding RNAs (lncRNAs) have been identified as potential prognostic biomarkers linked to immunological activities. In this study, we identified 1 downregulated lncRNA and 76 upregulated lncRNAs in LUAD samples from TCGA datasets. Among the 77 dysregulated lncRNAs, our attention focused on lncRNA LINC01833 (LINC01833). When compared with nontumor specimens, the level of expression of LINC01833 was shown to be significantly elevated in LUAD samples. In addition, the data of the ROC study revealed that LUAD patients with high LINC01833 expression had an AUC value of 0.840 (95% confidence interval: 0.804 to 0.876). There was a correlation between high LINC01833 expression and an advanced clinical stage. Patients who had a high expression of LINC01833 were shown to have a lower overall survival rate

p
<
0.001

and a lower disease-specific survival rate (p = 0.004) in comparison to patients who were in the low LINC01833 group, according to the data on survival. In addition, the results of the multivariate analysis revealed that high LINC01833 expression was an independent predictor of poor survival in LUAD. Moreover, the immune analysis revealed that we found that the expression of LINC01833 was positively associated with Th2 cells, aDC, and Tgd, while negatively associated with Mast cells, Tcm, Eosinophils, iDC, DC, Tem, Th17 cells, and pDC. Overall, our data point to the possibility that the unique lncRNA LINC01833 might be employed as a diagnostic and prognostic marker, and as a result, it has a significant impact on clinical practice.
Statistical Characterization and Modeling of Radio Frequency Signal Propagation in Mobile Broadband Cellular Next Generation Wireless Networks
Authors: Isabona Joseph , Ibitome Lanlege Louis , Imoize Agbotiname Lucky , Mamodiya Udit , Kumar Ankit , Hassan Montaser M. , Boakye Isaac Kweku
Published: January 2023

An accurate assessment of the spatial and temporal radio frequency channel characteristics is essential for complex signal processing and cellular network optimization. Current research has employed numerous models to figure out how much signal propagation loss occurs along the propagation paths. However, there are issues in finding the right model for a particular terrain because these models are not universally applicable. By employing the lognormal function and the Maximum Likelihood model, a hybrid probabilistic statistical distribution model was evolved. Three LTE cell site locations in Port Harcourt, Nigeria, were used to create a hybrid model that describes the functional stochastic signal propagation loss in the area. The evaluated Maximum Likelihood model accurately estimates the relevant wireless channel properties based on observed field data. The minor square regression approach and the proposed hybrid parameter estimation methodology are compared. When it comes to estimating standard deviation errors as well as the root mean square errors, the ML‐based approach consistently outperforms the least square regression model. Finally, the proposed hybrid probabilistic statistical distribution model would be useful for mobile broadband network planning in related wireless propagation conditions.
Moderating Role of Perceived Trust and Perceived Service Quality on Consumers’ Use Behavior of Alipay e-wallet System: The Perspectives of Technology Acceptance Model and Theory of Planned Behavior
Authors: Tian Yang , Chan Tak Jie , Suki Norazah Mohd , Kasim Mohd Ariff
Published: January 2023

The advancement of e-wallet systems, including Alipay, has led consumers to embrace digital payment with financial technologies. Yet, limited research focused on the usage of e-wallets in the context of emerging economies. This research is aimed at investigating the predictors of consumers’ use behavior of the Alipay e-wallet system in an emerging market and moderating role of perceived trust and perceived service quality on this relationship. The technology acceptance model (TAM) and the theory of planned behavior (TPB) were applied as the guiding principle. Data gathered via online surveys among 378 Malaysian Alipay users were analyzed using the partial least square-structural equation modeling (PLS-SEM) approach. The results reveal that all hypotheses were significant towards consumers’ intention to use Alipay in an emerging market except for the moderating role of perceived trust. Perceived usefulness was the strongest predictor factor towards consumers’ intention to use Alipay in an emerging market. This is followed by perceived ease of use. They heavily emphasize the superiorities of Alipay over other e-wallet systems such as efficiency and convenience for conducting financial activities. This study contributes to the existing literature by proposing a comprehensive integrated research model. The research outcome can serve as a guideline for service providers towards enhancing consumers’ adoption of e-wallets for digital payment with financial technologies.
Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
Authors: Liu Baoguo , Liu Sumei , Sun Dejun
Published: January 2023

Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important role in axonal growth. Moderate stabilization of microtubule promotes axonal growth and eliminates various intra- and extracellular mechanisms that impede axonal regeneration. After SCI, the damaged axons rapidly form a growth cone, wherein the stability of tubulin decreases, impairing axonal regeneration. Taxol with proven clinical safety is commonly used as a broad-spectrum antitumor drug. Importantly, Taxol can promote axonal extension by enhancing and stabilizing the microtubule assembly. In our study, we systematically investigated the differentiation of neural stem cells (NSCs) in vitro and functional recovery in injured rats in vivo following Taxol treatment. Low-dose Taxol promoted differentiation of NSCs to neurons and significantly extended the axons in vitro. In vivo, Taxol promoted the expression of βIII-tubulin in the injured areas and motor function recovery after SCI. Low-dose Taxol is a promising clinical agent to promote axonal regeneration after SCI.
Health Risk Assessment of Pesticide Residues in Drinking Water of Upper Jhelum Region in Kashmir Valley-India by GC-MS/MS
Authors: Ganaie M. Imran , Jan Ishrat , Mayer Afshan Nabi , Dar Alamgir A. , Mayer Ishtiaq A. , Ahmed Pervez , Sofi Javid A.
Published: January 2023

Globally growing demand for agricultural and farm foods has more or less become dependent on chemical pesticides to maintain the supply chain, which undoubtedly boosts agricultural production. However, pesticides not only impact the target pests but cause hazard to human health. Pesticides are ubiquitous and can be found in almost every component of the environment. They can therefore impair human and biota health when present over the threshold level. The present study assessed the concentration of commonly used pesticides for agricultural purposes but get mixed in different sources of water, as such fifteen sampling sites along the upper Jhelum basin of Kashmir valley were chosen. For the analysis, 60 water samples were obtained from different water sources. Gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) was used to determine pesticide residues in water samples. Pesticide residues from 10 of the 26 commonly used pesticides were detected in water samples. Difenoconazole had the highest concentration among the pesticides detected, with a mean concentration of 0.412 ± 0.424 μg/L ranging from 0.0 μg/L to 0.8196 μg/L. The target hazards quotient (THQ) was used to quantify the possible noncarcinogenic health risks associated with drinking pesticide-contaminated water. Only chlorpyrifos and quinalphos were detected >1 in RWS3 (1.6571), RWS4 (1.0285), RWS14 (1.2571), and RWS15 (1.2000) sample sites, implying that the drinking water poses a health risk to humans. Hence, pesticide hazards should be mitigated and rigorous monitoring is needed to reduce pesticide residues in drinking water.