bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Land Use and Tsunami Risk Mitigation Through Vertical Housing Development in Tsunami-prone Areas, Case Study: Banda Aceh City
Authors: Soviana Widya , Syamsidik Syamsidik , Munirwansyah Munirwansyah , Achmad Ashfa
Published: November 2023

The development of housing for communities in tsunami-prone areas in the city of Banda Aceh is experiencing significant progress. The majority of the constructed residences adhere to one-story and two-story house models. However, housing designed for single families requires larger land areas compared to apartment options, even though it can only accommodate a limited number of family members. Consequently, the availability of land for housing development is becoming increasingly constrained. Furthermore, single-family homes located in tsunami disaster risk zones are vulnerable to the impacts generated by such events. The development of housing models in regions with potential tsunami risks aims to minimize land utilization while still maintaining community well-being. Therefore, government policies are necessary to direct the development of vertically-conceptualized housing models as alternative dwellings for communities in tsunami-prone areas. These vertical housing models also serve as evacuation facilities during tsunami disasters, with the hope of safeguarding lives and reducing larger-scale losses in the future.
An insilico design of a peptide bioreceptor for cortisol using molecular modelling techniques
Authors: Deshpande Parijat , De Debankita , Badhe Yogesh , Tallur Siddharth , Paul Debjani , Rai Beena
Published: November 2023

Cortisol is established as a reliable biomarker for stress prompting intensified research in developing wearable sensors to detect it via eccrine sweat. Since cortisol is present in sweat in trace quantities, typically 8-140ng/mL, developing such biosensors necessitates the design of bioreceptors with appropriate sensitivity and selectivity. In this work, we present a systematic methodology and semi-automated high -throughput screening tool for candidate bioreceptors from protein databases, via molecular docking, ranking them according to their binding affinities by conducting automated AutoDock Vina scoring simulations and finally validation via full atomistic steered molecular dynamics computations including umbrella sampling to estimate the potential of mean force using GROMACS. These explicit molecular dynamic calculations are carried out in eccrine sweat environment taking into consideration the protein dynamics and solvent effects. Subsequently, we present a candidate baseline peptide bioreceptor selected as a continuous sequence of amino acids favourably interacting with the target ligand i.e., cortisol from the active binding site of the proteins and maintaining its tertiary structure. A unique cysteine residue introduced at the N-terminus allows orientation-specific surface immobilization of the peptide onto the gold electrodes and to ensure exposure of the binding site. Comparative binding affinity simulations of this peptide with the target ligand along with commonly interfering species e.g., progesterone, testosterone and glucose are also presented to demonstrate the validity of this proposed peptide as a candidate baseline bioreceptor for future cortisol biosensor development.
Quantum Feasibility Labeling for NP-complete Vertex Coloring Problem
Authors: Zhan Junpeng
Published: November 2023

Many important science and engineering problems can be converted into NP-complete problems which are of significant importance in computer science and mathematics. Currently, neither existing classical nor quantum algorithms can solve these problems in polynomial time. To address this difficulty, this paper proposes a quantum feasibility labeling (QFL) algorithm to label all possible solutions to the vertex coloring problem, which is a well-known NP-complete problem. The QFL algorithm converts the vertex coloring problem into the problem of searching an unstructured database where good and bad elements are labeled. The recently proposed variational quantum search (VQS) algorithm was demonstrated to achieve an exponential speedup, in circuit depth, up to 26 qubits in finding good element(s) from an unstructured database. Using the labels and the associated possible solutions as input, the VQS can find all feasible solutions to the vertex coloring problem. The number of qubits and the circuit depth required by the QFL each is a polynomial function of the number of vertices, the number of edges, and the number of colors of a vertex coloring problem. We have implemented the QFL on an IBM Qiskit simulator to solve a 4-colorable 4-vertex 3-edge coloring problem.
Early disease-specific characteristics for identifying Mixed Vascular-Alzheimer's Dementia in geriatric patients
Authors: Jaul Efraim , Factor Hagai , Meiron Oded
Published: November 2023

Purpose
Mixed Vascular-Alzheimer's Dementia (MVAD) is coexistence of both Alzheimer's disease and cerebrovascular disease (CVD) in the same patient. Thus, the current investigation focused on retrospectively classifying and diagnosing older geriatric patients at risk for dementia with both vascular risk factors and neuro-atrophy factors in Alzheimer's disease (AD)versus patients with nonvascular-AD etiology.
Methods
The study evaluated demographic and clinical data collected from a cohort of 192 geriatric out-patients (age range = 60–97 years) admitted for one baseline and one follow-up clinical consultations within a period of three years. Mini Mental State Examination (MMSE) scores and cardiovascular risk factors were reevaluated and utilized in the assessment of basic cognitive functioning and clinical diagnosis of MVAD and AD dementia subgroups during follow-up visits.
Results
A relatively high prevalence of MVAD diagnosis was found across the entire sample (36%). MVAD diagnosis was significantly higher in men with 59% prevalence, while AD diagnosis without vascular etiology was significantly higher in women with 69% prevalence. MVAD diagnosis was more pronounced under the age of 85, while AD diagnosis without vascular history was significantly higher in ages 85 years or older. Importantly, non-palpations of peripheral pulse and atrial fibrillation-type arrhythmia were found to be significant early risk factors related to prospective MVAD diagnosis (p < .008, OR = 30, p < .009, OR = .005).
Conclusion
Early comprehensive clinical evaluation of specific vascular risk factors prior to dementia onset could putatively predict the onset of MVAD.
The anxiety response of patients with severe psychiatric disorders to the recent public health crisis
Authors: Khalkhali Mohammadrasoul , Zarvandi Parsa , Mohammadpour Mehrshad , Alavi Seyed Mohsen Kheirkhah , Khalkhali Parnian , Farrahi Hassan
Published: November 2023

Background
The recent public health crisis, COVID-19, has had devastating health, economic, and social consequences in many societies. These consequences harmed to the already vulnerable groups, particularly people with Sever Psychiatric Disorders (SPDs). The present study was conducted with the aim of investigating the anxiety response of patients with SPDs during COVID-19 pandemic.
Methods
This cross-sectional analytical study was conducted on 351 patients with SPDs [schizophrenia spectrum (SSD), bipolar (BD), major depressive (MDD), and obsessive-compulsive (OCD) disorders] and a control group in Guilan province. The anxiety response consisted of four concepts: COVID-19-related anxiety, general health anxiety, anxiety sensitivity, and safety behaviors. After conducting a clinical unstructured interview with all participants, the self-report measures, including the Corona Disease Anxiety Scale, the Anxiety Sensitivity Index – Revised, the Short Health Anxiety Inventory, and the Checklist of Safety Behaviors, were administered.
Results
ANOVA showed a significant difference between the groups of patients with SPDs and the control group in COVID-19-related anxiety (F = 6.92, p = 0.0001), health anxiety (F = 6.21, p = 0.0001), and safety behaviors (F = 2.52, p = 0.41). However, no significant difference was observed between them in anxiety sensitivity (F = 1.77, p = 0.134). The Games-Howell test showed that the control group obtained a higher mean than the groups of people with BD (p < 0.0001), SSD (p = 0.033), and OCD (p = 0.003) disorders in COVID-19-related anxiety. Also, the MDD (p = 0.014) and OCD (p = 0.01) patients had a higher mean than the control group in health anxiety. Tukey's test showed that the mean of safety behaviors of the control group was significantly higher than the OCD group (p = 0.21). No difference was observed between the groups of MDD, BD, SSD, and OCD in terms of COVID-19-related anxiety, health anxiety, and safety behaviors.
Conclusion
Anxiety response to health crisis is different in groups with SPDs and control group. These difference in responses shows that patients with SPDs may have special needs in the occurrence of health crises. It also warns that having a mental illness is not necessarily associated with maladaptive reactions in health crises.
Technical Analysis of Detection of Vitis Amurensis Wine Volatiles Based on HS-SPEM-GC-MS
Authors: Li Ming , Cui Yanyan , Lei Jiayi , Shen Qi
Published: November 2023

Vitis amurensis wine is a Chinese specialty wine product. This study investigated the effects of different sample processing methods on the detection of volatile components of Vitis amurensis wines using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME-GC-MS). The effects of sample volume, sample concentration, extraction temperature, equilibrium time, adsorption time, stirring speed, sodium chloride, and desorption time on the assay results were explored. The results showed that the sample processing methods significantly impacted the assay results, especially for low-concentration volatiles, which were detected less frequently. However, this effect could be compensated by increasing the adsorption time, adding saturated NaCl and increasing the number of parallel experiments. When the results were statistically analyzed, high matching (probability) reduced the variability of the parameters at different levels, and the detection conditions could not be optimized by regression analysis, but low matching reduced the accuracy of the results. Moreover, the sensitivity of the instrument exerted an effect on the assay results.
Harnessing Voice Analysis and Machine Learning for Early Diagnosis of Parkinson's Disease: A Comprehensive Study Across Diverse Datasets
Authors: Neto Osmar Pinto
Published: November 2023

Objective
To evaluate the efficacy of integrating voice analysis with machine learning techniques for the early diagnosis of Parkinson's Disease (PD) across diverse datasets.
Methods
Voice data were sourced from three distinct datasets available on the UCI Machine Learning Repository. These datasets encompassed voice measurements from various PD patients and healthy individuals, characterized by different voice recording exercises and conditions and including time and spectral voice features. Machine learning models were trained and validated using these features to differentiate between PD patients and healthy subjects.
Results
Our machine learning model demonstrated high diagnostic accuracy across all datasets. Specifically, the model achieved promising indicators of efficacy, including high averages across datasets of accuracy (99% ± 3.9%), sensitivity (98.8% ± 5.3%), specificity (99.1% ± 5.1%), precision (98.5% ± 4.2%), F1 score (97.9% ± 4.9%), and ROC AUC (99.3% ± 2.7%). The results were consistent across datasets, highlighting the model's robustness and adaptability.
Conclusion
The integration of voice analysis with machine learning offers a promising avenue for the early diagnosis of PD. Given the non-invasive nature and cost-efficiency of voice analysis, this approach could revolutionize early PD detection and monitoring. While the preliminary results are encouraging, further validation in clinical settings and larger cohorts is essential before widespread adoption.
Bemerkenswerte Pflanzenarten entlang des Radweges zwischen Kläden und Uchtspringe (Landkreis Stendal)
Authors: Brennenstuhl Günter
Published: November 2023

Die Fundorte von für die Altmark bemerkenswerten Pflanzenarten, die 2007–2011 am Radweg zwischen Kläden und Uchtspringe (Landkreis Stendal) beobachtet wurden, werden auf der Basis von Messtischblatt-Viertelquadranten mitgeteilt. Auf die Populationsentwicklung einiger Arten wird eingegangen.
Gentiana lutea L., Gentiana pannonica Scop. und deren Hybriden auf der Brockenkuppe im Nationalpark Harz
Authors: Karste Gunter , Budahn Holger
Published: November 2023

Der Gelbe Enzian (Gentiana lutea) und der Ungarische Enzian (Gentiana pannonica) gehören zu den montan bis subalpin verbreiteten Arten, welche im Harz nicht ursprünglich heimisch sind, sondern nach Anlage des Brockengartens im Jahr 1890 dort angepflanzt wurden. Nach erfolgreicher Etablierung unter den spezifischen klimatischen Bedingungen der Brockenkuppe konnten sich beide Enziane, wie ca. 30 weitere Gefäßpflanzenarten, über das Gartenareal hinaus ausbreiten und werden heute auch an verschiedenen Standorten auf der Kuppe gefunden. Kreuzungen von G. lutea und G. pannonica wurden schon von Wyneken (1938) beschrieben. Eine Distanzanalyse mittels molekularer Marker soll einen detaillierteren Einblick in das interspezifische Hybridisierungsgeschehen liefern. Diskutiert werden Fragen der 1890 eingeleiteten Florenverfälschung auf dem Bergplateau.
Orthotrichum rogeri BRID. (Bryophyta) neu in Sachsen-Anhalt
Authors: Eckstein Jan
Published: November 2023

Orthotrichum rogeri wurde kürzlich erstmals in Sachsen-Anhalt, im Harz, nachgewiesen. Hier wird über den zweiten Fund der Art in Sachsen-Anhalt berichtet. Der neue Fundort liegt nordöstlich Grockstädt im FFH-Gebiet 137 „Schmoner Busch, Spielberger Höhe und Elsloch südlich Querfurt“.
Bemerkenswerte Funde Höherer Pflanzen und Moose im Südteil von Sachsen-Anhalt
Authors: Korsch Heiko
Published: November 2023

Von 2008–2011 wurden vom Autor in weiten Gebieten im Südteil von Sachsen-Anhalt die Characeen kartiert. Dabei gelang auch eine Reihe bemerkenswerter Funde Höherer Pflanzen und Moose. Besonders herausgehoben werden sollen die Funde von Najas marina, N. minor sowie Utricularia minor
Zur Einwanderungs- und Ausbreitungsgeschichte von Corispermum leptopterum (ASCHERS.) ILJIN im Raum Salzwedel
Authors: Brennenstuhl Günter
Published: November 2023

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Stinsenpflanzen in altmärkischen Parkanlagen
Authors: Brennenstuhl Günter
Published: November 2023

Es wurden acht altmärkische Parkanlagen, sechs im Altmarkkreis Salzwedel und zwei im Landkreis Stendal, auf Vorkommen von Stinsenpflanzen untersucht. Die Ergebnisse werden vorgestellt. Da es sich größtenteils um fremdländische, einst angepflanzte und nun verwilderte Zierpflanzen handelt, wird auf ihre Herkunft eingegangen und der Grad ihrer Einbürgerung in der Lokalflora eingeschätzt. Bei bemerkenswerten und bestimmungskritischen Taxa werden die zur Identifizierung verwendeten Erkennungsmerkmale aufgeführt. Einer Übersichtstabelle können die Fundorte der 27 nachgewiesenen Stinsenpflanzen entnommen werden.
Cochlearia danica L. in Sachsen-Anhalt mittlerweile weit verbreitet
Authors: Krumbiegel Anselm
Published: November 2023

Bisher lagen von Cochlearia danica nur vergleichsweise wenige Fundmeldungen aus Sachsen-Anhalt vor. Im Kontrast dazu stand das seit einigen Jahren häufige Vorkommen entlang von Straßen, was dazu bewog, die Verbreitung vor allem in der Umgebung von Halle näher zu untersuchen. Dazu wurden mehr als 600 km Straßen bzw. Richtungsfahrbahnen (Autobahnen, vier- und zweispurige Bundesstraßen, Landstraßen) erfasst und an dem ganz überwiegenden Teil der Straßenabschnitte die Art in unterschiedlicher Dichte nachgewiesen. An einigen Stellen wurden Belegaufnahmen zur Ermittlung der Vergesellschaftung erstellt. Das Spektrum der Begleitarten ist standortbedingt sehr heterogen und unspezifisch aber gleichzeitig typisch für solche Straßenrandhalophyten. Gleichzeitig zeigte sich die ebenfalls weite Verbreitung von Plantago coronopus subsp. coronopus als steter Begleiter von Cochlearia danica.
Funde und Beobachtungen von höheren Pflanzen im südlichen Sachsen-Anhalt
Authors: John Heino , Zenker Edgar
Published: November 2023

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Verwilderungen von Spiraea-Taxa in der Umgebung von Salzwedel (Altmark)
Authors: Brennenstuhl Günter
Published: November 2023

Im Beobachtungsgebiet sind Verwilderungen von acht Spiraea-Taxa nachgewiesen worden. Bei einigen Populationen konnte deren Entwicklung über 30 Jahre verfolgt werden. Am erfolgreichsten behaupten sich die Spiersträucher mit unterirdischen Ausläufern: Spiraea alba Du Roi var. alba, S. alba var. latifolia (Aiton) Dippel, S. ×billardii agg. Herincq, S. chamaedryfolia L., S. douglasii Hook. var. douglasii und S. douglasii var. menziesii (Hook.) Calder et Roy L. Taylor. Sie sind imstande, großflächige Dominanzbestände zu bilden und werden als lokal eingebürgerte Neophyten angesehen. Dagegen treten S. japonica L. f. und S. ×vanhouttei (Briot) Carriére nur selten und in Einzelexemplaren auf. Ihr floristischer Status wird als unbeständig eingeschätzt. Neben der Mitteilung der Fundorte wird bei allen beobachteten Taxa auf die bei der Determination verwendeten Merkmale eingegangen.
Ionizing radiation effects on microorganisms and its applications in the food industry
Authors: Danyo Emmanuel Kormla , Ivantsova Maria , Selezneva Irina
Published: November 2023

There are two main types of radiation: ionizing and non-ionizing. Radiations are widely distributed in the earth’s crust with small amounts found in water, soil, and rocks. Humans can also produce them through military, scientific, and industrial activities. Ionizing and nonionizing radiations have a wide application in the food industry and medicine. γ-rays, X-rays, and electron beams are the main sources of radiation used in the food industry for food processing. This review discusses advantages and disadvantages of ionizing radiation on microorganisms and its potential applications in the food industry. We also looked at its advantages and disadvantages.

Studies have revealed that ionizing radiation is used in the food industry to inactivate microorganisms in food products to improve hygiene, safety, and extend shelf life. Microorganisms such as bacteria and fungi are susceptible to high doses of irradiation. However, some bacterial and fungal species have developed an exceptional ability to withstand the deleterious effect of radiation. These organisms have developed effective mechanisms to repair DNA damage resulting from radiation exposure.

Currently, radiation has become a promising technology for the food industry, since fruits, tubers, and bulbs can be irradiated to delay ripening or prevent sprouting to extend their shelf life.
Partitioning blue and green water sources of evapotranspiration using the water evaluation and planning (WEAP) model
Authors: Kidanewold Belete Berhanu , Zeleke Ethiopia Bisrat , Michailovsky Claire , Seyoum Solomon
Published: November 2023

Understanding agricultural water use by sources such as rainwater (green water) or irrigation water (blue water) is vital to manage scarce freshwater resources. Tracing sources of evapotranspiration increases water management efficiency. This study proposes a two-bucket soil moisture water balance approach to trace sources of evapotranspiration over irrigated landscapes in the Awash Basin, Ethiopia, which is modeled in the water evaluation and planning model. Algorithms are devised to separate actual evapotranspiration into blue and green sources. The results showed annual basin renewable water of 15.78 BCM in the form of streamflow (4.65 BCM), stored water (3.54 BCM), and groundwater percolation (7.59 BCM). Annual actual evapotranspiration over irrigated landscapes was 805 MCM, which was separated as blue evapotranspiration (88.4%) and green evapotranspiration (11.6%). The findings also demonstrate that blue evapotranspiration predominantly occurs during dry months, indicating heavy reliance on stored water for irrigated landscapes. Subbasin-level analyses showed varying blue/green evapotranspiration patterns based on precipitation and irrigated agriculture. Irrigation accounted for less than 3% of the streamflow in upstream basins, while midstream and downstream basins utilized up to 30 and 70%, respectively. The complementary use of rainfall and irrigation in most parts of the basin is considered to be of interest to water managers.
Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract
Authors: Li Yan , Tang Li , Dang Guanxing , Ma Mengyuan , Tang Xingfang
Published: November 2023

Background:

Scinderin (SCIN) is a calcium-dependent protein implicated in
cell growth and apoptosis by regulating actin cleavage and capping. In this study, we
investigated the role of SCIN in hydrogen peroxide-induced lens epithelial cell (LEC)
injury related to age-related cataract (ARC).

Methods:

Anterior lens capsules from ARC patients were collected to examine SCIN
expression levels. Immortalized human LEC cell line SRA01/04 and lens capsules
freshly isolated from mice were induced by H2O2 to mimic the oxidative stress in ARC.
The role of SCIN was investigated by gain-of-function (overexpression) and loss-offunction
(knockdown) experiments. Flow cytometry (FCM) and Western-blot (WB)
assays were performed to investigate the effect of SCIN on apoptosis. The oxidative
stress (OS) was examined by detecting malondialdehyde (MDA) level, superoxide
dismutase (SOD) and catalase (CAT) activity. The interaction between SCIN mRNA
and miR-489-3p was predicted by StarBase and miRDB databases and validated by
luciferase reporter activity assay.

Results:

SCIN was significantly elevated in cataract samples, and the expression
levels were positively correlated with the nuclear sclerosis grades. SCIN
overexpression promoted OS and apoptosis in H2O2-induced SRA01/04 cells, while
SCIN silencing showed the opposite effect. We further showed that miR-489-3p was a
negative regulator of SCIN. miR-489-3p overexpression suppressed apoptosis and OS
in H2O2-induced SRA01/04 cells by targeting SCIN.

Conclusion:

Our study identified SCIN as an upregulated gene in ARC, which is
negatively regulated by miR-489-3p. Targeting miR-489-3p/SCIN axis could attenuate
OS-induced apoptosis in LECs.
Perceived Need, Unmet Need for Mental Health Care and Related Factors Among Mothers of Children with Autism Spectrum Disorder in Hamadan, Western Iran
Authors: Ayubi Erfan , Seyedi Mahdieh , Shafiei Roya , Jenabi Ensiyeh
Published: November 2023

Background:

There is no reliable data on the perceived need of mothers of children
with autism spectrum disorder (ASD) for mental services, and it is unclear how much of mothers'
needs are met in Western Iran.

Objective:

This study aimed to quantify the perceived need and avoidance/delay for mental
health care among mothers of children with ASD and also to elucidate the factors associated with
perceived need and avoidance/delay.

Methods:

This is a cross-sectional study involving all mothers of children with ASD in Hamadan
City, Western Iran. Socio-demographic characteristics, depression, anxiety, stress as well as perceived
need and avoidance/delay, and associated factors were obtained using researcher-made and
standard validated questionnaires. Penalized logistic regression analysis via data augmentation
was used to estimate the odds ratio (OR) and 95% confidence interval (CI).

Results:

In total of 103 mothers, approximately 75% and 61% of mothers reported a perceived
need and avoiding/delaying needed services during the past 12 months, respectively. Psychological
stress and lower family income were significant determinants of the perceived need for mental
health care. Minimization (OR: 6.06; 95% CI: 1.33-27.68), low perceived treatment effectiveness
(4.40; 1.05-18.35), and financial barrier (4.26; 1.01-17.86) were the most important reasons for
avoiding/delaying needed services, respectively.

Conclusion:

The prevalence of perceived needs and unmet needs is high. Effective psychosocial
interventions should be provided to reduce the mental health care gap among mothers of children
with ASD.
Sexual Function and Satisfaction among Women Undergoing In Vitro
Fertilization (IVF) in the West of Iran: A Cross-Sectional Study
Authors: Abdoli Sara , Khazaei Salman , Jenabi Ensiyeh
Published: November 2023

Background:

We haven’t found any reported study that addressed sexual function and
satisfaction in infertile women who are undergoing IVF treatment in the west of Iran.

Objective:

The present study was conducted to investigate sexual performance and satisfaction
among women undergoing in vitro fertilization (IVF) in Western Iran.

Methods:

This cross-sectional study was conducted on 170 women from December 2022 to
March 2023. The participants were selected by convenience sampling until the sample size was
reached. The participants were included in the study as available sampling. Women completed the
demographic questionnaire, FSFI (female sexual function index), and Linda Berg’s Sexual Satisfaction
Questionnaire. For data analysis, we used the Stata version 14 (StataCorp, College Station,
TX) and we considered the P-value less than 0.05 significant.

Result:

There was a significant relationship between husband occupations, economic status, marriage
duration, period of infertility, cause of infertility, and intercourse times with sexual satisfaction
(P< 0.05). The highest percentage of the obtained score was related to pain (51.6%) and the
lowest was related to desire (38%). All of the patients with weak sexual function had weak sexual
satisfaction and 60.19% of the patients with good sexual function had good sexual satisfaction
(P< 0.001).

Conclusion:

Women with weak sexual function had weak sexual satisfaction. Policymakers
should consider strategies, such as counseling and psychological support for women during the
treatment process to help them cope with their problems, especially psychological problems.
Design of a portable device to improve confidence, stability, and sanitation during toilet self-transfers
Authors: Furstenberg Emily , Blake Rivas Linda , Belko Sara , Pugliese Robert , Ku Bon , Hutchinson Morgan
Published: November 2023

Our team interviewed wheelchair users, physical therapists, and occupational therapists and identified toileting as a major challenge. Many wheelchair users feel unsafe performing toilet transfers, especially in public spaces, because existing transfer products do not meet users’ needs. We identified independence, portability, stabilisation, ease of use, and sanitation as important factors based on user interviews. We produced a weight-bearing prototype and refined the design via user surveys used to validate our concept, assess user perception of the device, and inform us on how users would interact with it. When surveyed, 94.4 per cent of respondents indicated interest in using our Grip ‘N Go device.
Cybersecurity of Critical Infrastructure Facilities
Authors: Fedotova G. V. , Kapustina Yu. A. , Churaev A. G. , Yuldashbayeva Z. Yu.
Published: November 2023

Relevance. The cybersecurity of information systems and services is becoming one of the important criteria for the quality of services and production of goods in modern society, just like the stability and speed of data transfer. Developers of software products and applications are concerned about the increase in the number of attacks on their systems, the increase in the theft of information and assets. The confrontation between Russia and NATO countries has intensified the growth of geopolitical threats and hacker intrusions into the information system of Russia with the aim of destabilizing and deactivating it. At the same time, Rostelecom-Solar noted that hackers are especially attracted to the critical infrastructure of the Russian economy. The purpose of the study was to evaluate modern technologies for protecting digital services used by companies and to identify new approaches to strengthening security systems. Objectives. The following tasks were set and consistently solved in the article: to assess the current trends in the transformation of information systems, as well as objects of critical information infrastructure in the light of the increasing attacks of hackers; propose a new approach to solving cybersecurity problems. Methodology. The methods of graphical, horizontal and logical analysis, generalization and systematization of data were used in the work. Results. Based on a general review of technologies for protecting critical infrastructure, both from the side of the state and from the side of business, it was concluded that it is necessary to form a triad of visibility of vulnerabilities. Conclusions. The article considers the directions of restructuring the entire cyber industry and the formation of a new vector for the development of the digital world in the context of changing geopolitical confrontations between developed powers. It is concluded that it is necessary to change the paradigm of the technology market in the direction of transferring all programs to Russian technologies and intensifying their promotion to the EAEU countries, which will allow building a new Eurasian IT market under the guidance of the Russian Federation.
Economic and Mathematical Assessment of the Impact of Investment Activity on the Spatial Development of the Region
Authors: Vertakova Yu. V. , Pozhidaev S. Yu. , Artsybasheva V. O. , Yai Liu
Published: November 2023

The relevance of assessing the impact of investment activity on the main macroeconomic indicators is due to the fact that in order to improve the quality of life of the population and achieve sustainable development within the framework of the spatial development strategy, the most active attention is paid to directing resources to create favorable conditions for its economic and social development on the territory of a particular subject of the Federation. The achievement of these goals is largely related to the effectiveness of investment activity, the sustainability of regional development and its main macroeconomic indicators depend on its effectiveness. The purpose of the study is to substantiate the impact of investments on the main economic indicators of the region's development, on its spatial development. Objectives: to build basic economic and mathematical models describing these relationships in the economy of the Kursk region; to calculate how much a change in investment changes GRP, how investments are related to changes in spatial development and monetary policy; to determine the multiplier of investments and the time lag of their impact on the spatial development of the region. Methodology. The general scientific methods of analysis and special methods of economic and statistical research were used in the study. Results: the main interrelations within the framework of Keynesian models of economic theory were obtained; to assess the effectiveness of spatial development, the main macroeconomic indicators characterizing the economic and social development of the Kursk region were considered. Conclusions: the activity of investment activity increases the efficiency of the regional economy, investments give a systemic effect on the development of all branches of the regional economy, and not only those enterprises in which investment projects are implemented. At the same time, the effect has a time lag, which is 2 years for the economy of the Kursk region.
Diffusion of Private and Public Institutions: a Global Aspect
Authors: Alpidovskaya M. L. , Sirotkina A. I.
Published: November 2023

Relevance. The article is devoted to the study of global legal and illegal private structures. The relevance of this research is due to the global structural crisis, the need for scientific ways to resolve the accumulated contradictions within the framework of the functioning of the global liberal paradigm, which at the current stage of development is characterized by a general criminalization of the economy, mutual integration of private and public structures, as a result, degradation of the institution of the state with the subsequent formation of a global pyramid of private power. The purpose of the study is to identify trends in the formation of a single private transnational network structure. Objectives. This goal is achieved by performing the following tasks: identifying trends in internationalization and transnationalization of private structures, and the relationship between private and public structures on a global scale by strengthening socio-economic interaction, including through the organization of large-scale financial flows, revealing the synthesis of shadow and legal financial sectors of the global economy, analyzing the impact of legal and illegal activities the impact of private multinational companies on the global economy, studying the specifics of criminalization of the global economy in general and the financial sector in particular in the context of the global structural crisis. Methodology. The implementation of these tasks is carried out using such research methods as system analysis, synthesis, generalization, interpretation of results. In the course of the study, empirical and statistical data, scientific papers, reports of relevant ministries and departments in the field under consideration were systematized, the interpretation of the analysis of global socio-economic processes in the form of a flowchart was implemented. The results of the conducted research are modeling of the emerging global supranational structure. Conclusions. The tendencies of the formation of a private transnational network structure, which includes both legal (transnational banks) and illegal (transnational criminal associations) private structures, are determined. These trends can be traced at various levels of socio-economic interaction, including financial, of these structures.
Self-Employment for Students: Realities and Prospects of Development in the Modern Economy
Authors: Pyanova N. V. , Stolyarova E. A. , Pyanov R. R.
Published: November 2023

Relevance. The emergence of self-employment in the economic system of Russia undoubtedly has a significant role, as evidenced by the experiment of 2019. This experiment on the introduction of a tax on professional income has acquired special significance, showing a high increase in the number of taxpayers. The expansion of formal employment contributes to the development of entrepreneurship of small and medium-sized business entities, which in general gives impetus to the acceleration of socio-economic development of the regions of Russia. The relevance of the chosen topic is due to the fact that everyone should fully know their own capabilities and rights to use resources as a source of profit. Thus, the article analyzes the process of forming the legal status of a self-employed citizen. The purpose of this work is to assess the issue of students acquiring self-employed status. Objectives: based on the analysis of psychological and pedagogical literature, to consider the concept of "selfemployed"; to reveal the advantages and disadvantages, privileges and opportunities of this status for students; to identify the essence and highlight the main distinctive components; to reveal the activities of self-employed students; to analyze the statistical data of the subjects of the Russian Federation. Methodology. In the process of studying the issue of acquiring the status of self-employed, methods of logical, comparative, statistical analysis, classification, generalization, theoretical analysis of scientific and methodological literature, economic and statistical methods were used. The results of the study show that the growth of the self-employed does not decrease the pace. Although the status of self-employed has a large number of positive characteristics for students, however, many young people are not fully informed about the new tax regime. The conclusion based on the results of the study indicates that currently self-employment provides ample opportunities for those who want to try their hand at entrepreneurship. This is a great way to successfully monetize unique abilities, hobbies, invaluable experience and favorite hobbies.
Determining of internal factors affecting compliance of pregnant women in Covid-19 vaccination
Authors: Sari Devi Permata , Elsera Chori , Hamranani Sri Sat Titi
Published: November 2023

Background:Covid-19 vaccination for pregnant women was an effort to prevent and transmit Covid-19 to pregnant women. Obedience of pregnant women is the behavior of pregnant women in accordance with the guidelines. Compliance of pregnant women in the Covid-19 vaccination is important to study because it is to increase the complete adherence of pregnant women in the Covid-19 vaccination, thereby increasing the immunity of pregnant women. Internal factors that can influence pregnant women's

 

compliance with Covid-19 vaccination include the pregnant woman's age, gestational age, educational status, employment, knowledge, motivation, perception and self- efficacy.

Objectives: Analyzing the relationship between maternal age, gestational age, educational status, occupation, income, knowledge, motivation, perception, and self- efficacy with pregnant women's adherence to the Covid-19 vaccination.Analyze the internal factors that most influence the adherence of pregnant women in the Covid-19 vaccination.

Methods: The research design used a quantitative descriptive with a cross sectional approach. The population in this study amounted to 86 pregnant women. The sampling technique used quota sampling with a sample of 46 pregnant women. The research instrument uses a questionnaire that has been tested for validity and reliability. Data analysis using Chi Square Test and multiple regression.

Results: The results of the study showed that the factor associated with the compliance of pregnant women in the Covid-19 vaccination was gestational age (p value 0.002). Meanwhile, factors that were not related to the compliance of pregnant women in the Covid-19 vaccination were the age of the pregnant mother (p value 0.497), educational status (p value 0.252), occupation (p value 0.829), income (p value 0.605), knowledge (p value 0.351), motivation (p value 0.558), perception (p value 0.295), and self-efficacy (p value 1.000).

Conclusions: The conclusion of this study is that the factor that most influences pregnant women's adherence to the Covid-19 vaccination is gestational age with a p- value of 0.005 (a = 0.05) and respondents with a younger gestational age are at risk of

0.047 times experiencing non-adherence to Covid-19 vaccination.
The effectiveness of maternal voice in critically ill children undergoing suctioning with acute pain
Authors: Astuti Astuti , Nurhaeni Nani , Waluyanti Fajar Tri , Apriyanti Efa , Mutifa Juanda , Ardi Ni Bodro
Published: November 2023

Background: Acute pain during suction in pediatric patients in the intensive care unit is unavoidable. However, it is necessary to provide non-pharmacological interventions that nurses can guide. One of the interventions that can applied in that situation is maternal voice. That intervention giving the opportunity to the children hearing the voice of their mother via voice recorder.

Objective: This study was conducted to determine the effect of maternal voice on acute pain experienced by critically ill children during suctioning procedure.

Methods: The research method used was quasi experiment pretest posttest without control group design. The study was conducted in May-June 2022 in the PICU in one of the hospitals in Jakarta. The research sample was selected by purposive sampling, 21 respondents assessed at the time of pretest and post-test (5 minutes before suctioning procedure, during procedure, and 5 minutes after procedure). The pain of the critically ill children was observed by FLACC (Face, Leg, Activity, Cry, Consolability) Scale.

Results: The Saphiro Wilk test of normality data was carried out for all the data, either pretest or post-test data. Bivariate tests were analysed using Wilcoxon Signed Rank Test (for the abnormal data) and Paired T-Test (for the normal data) with the results of pain scores before and after being given maternal voice (when starting suction, p value = 0.001; after starting suction, p value = 0.001; 5 minutes after suction, p value = 0.002).

Conclusions: PICU nurses should practice maternal voice along with suction to reduce the pain sensation received by children.
The expression miRNA-195 in a sample of Iraqi breast cancer patients.
Authors: Ibraheem AL-saqabi Ahmed Nasser , Hussein Aziz Ismail
Published: November 2023

Breast carcinoma is the most prevalent cancer-related cause of death in women,
and metastasis is the main factor in morbidity. The total number of new cases of
cancer in Iraq during the year 2019 was 35,864. New non-invasive prognostic biomarkers are needed for the rapid recognition and differentiation between breast
cancer (BC) stages for treatment choice improvement. MicroRNA (miRNA) are
small, noncoding RNAs regulating gene expression and involve many cellular
processes, including metastasis. Circulating miRNAs (detected in the blood)
show considerable potential as biomarkers for helping diagnosis or tracking
treatment efficacy. Materials and Methods: total RNA was extracted from serum
from (n=50) patients and (n=26) healthy control to measure the MicroRNA 195
expression using SYBR green-based real-time RT-PCR technology. As a result,
the expression levels miR-195 in breast cancer patients’ serum were significantly
increased (up-regulated) compared to those in the normal adjacent serum. BC
group showed a higher significant miR-195 expression (upregulation) when
compared with those in the control group. While the highest expression of miR195 was recorded in stage II.
Keywords: Breast Cancer, MicroRNA, miR-195, Stage, Iraq
The Journey of Data Within a Global Data Sharing Initiative: A Federated 3-Layer Data Analysis Pipeline to Scale Up Multiple Sclerosis Research
Authors: Pirmani Ashkan , De Brouwer Edward , Geys Lotte , Parciak Tina , Moreau Yves , Peeters Liesbet M
Published: November 2023

Background

Investigating low-prevalence diseases such as multiple sclerosis is challenging because of the rather small number of individuals affected by this disease and the scattering of real-world data across numerous data sources. These obstacles impair data integration, standardization, and analysis, which negatively impact the generation of significant meaningful clinical evidence.

Objective

This study aims to present a comprehensive, research question–agnostic, multistakeholder-driven end-to-end data analysis pipeline that accommodates 3 prevalent data-sharing streams: individual data sharing, core data set sharing, and federated model sharing.

Methods

A demand-driven methodology is employed for standardization, followed by 3 streams of data acquisition, a data quality enhancement process, a data integration procedure, and a concluding analysis stage to fulfill real-world data-sharing requirements. This pipeline’s effectiveness was demonstrated through its successful implementation in the COVID-19 and multiple sclerosis global data sharing initiative.

Results

The global data sharing initiative yielded multiple scientific publications and provided extensive worldwide guidance for the community with multiple sclerosis. The pipeline facilitated gathering pertinent data from various sources, accommodating distinct sharing streams and assimilating them into a unified data set for subsequent statistical analysis or secure data examination. This pipeline contributed to the assembly of the largest data set of people with multiple sclerosis infected with COVID-19.

Conclusions

The proposed data analysis pipeline exemplifies the potential of global stakeholder collaboration and underlines the significance of evidence-based decision-making. It serves as a paradigm for how data sharing initiatives can propel advancements in health care, emphasizing its adaptability and capacity to address diverse research inquiries.
Nghiên cứu khả năng hấp phụ xanh methylene của than sinh học sản xuất từ cành thanh long (Hylocereus Sp.)
Authors: Đỗ Hải Sâm , Trần Tuyết Sương , Nguyễn Trung Hiệp , Trần Anh Khoa , Thái Phương Vũ
Published: November 2023

Nghiên cứu trình bày quy trình xử lý cành thanh long bằng phương pháp nhiệt phân ở 550oC thu than sinh học, ứng dụng xử lý chất màu xanh methylen (MB) trong nước thải. Kết quả khảo sát cho thấy khi thời gian hấp phụ là 90 phút với nồng độ MB 40 mg/L thì hiệu suất hấp phụ có thể đạt > 95% đối với 0,3 g biochar sử dụng trong khoảng pH 8-11. Nghiên cứu xây dựng mô hình đẳng nhiệt cho thấy quá trình hấp phụ MB bằng than từ cành thanh long phù hợp với mô hình hấp phụ đơn lớp Langmuir với độ tuyến tính R2 = 0,9889 và dung lượng hấp phụ cực đại là 13,7 mg/g. Khảo sát động học cho thấy mô hình động học giả bậc 2 là phù hợp để giải thích động học quá trình hấp phụ MB lên than sinh học. Các kết quả khảo sát này chứng tỏ than sinh học từ nhiệt phân cành thanh long có thể ứng dụng trong lĩnh vực xử lý nước thải bằng phương pháp hấp phụ nhằm giải quyết vấn đề ô nhiễm từ cành thanh long và MB.
Research on the Path of Civic-Political Construction of Courses under the “One Body, Two Wings” Model—The Principles and Practice of Engineering Law Course as an Example
Authors: Tong Di , Liu Xiaojing
Published: November 2023

Comprehensively promoting the construction of college curriculum ideology and politics is a major strategic initiative to deeply implement General Secretary Xi Jinping’s important thesis on education and implement the fundamental task of establishing moral education, colleges and universities should deepen the reform of education and teaching, deeply excavate the ideological and political resources of the curriculum, and give full play to the nurturing role of each course, so as to comprehensively improve the quality of talent cultivation. The Principles and Practice of Engineering Law course has explored and practiced the path of the construction of course ideology and politics, and explored the path of the construction of course ideology and politics of the course with the construction idea of “one body and two wings” model, taking the development of students as the basis, and the innovative application in teaching and value shaping for students as the two wings of the teaching. Value shaping not only focuses on the actual situation of the students to explore the elements of the course Civics, the teacher should also set an example, set an example, moral and humanistic, in addition to the establishment of a scientific and effective evaluation system of the teaching effect of the course Civics to ensure that the whole course Civics education effect. The entire course is taught in such a way that the students not only learn knowledge and skills, but also are all in one piece and realize the nurturing goals of the course.
Analyzing the Role of AI in Cyber Security Threat Detection & Prevention
Authors: Maurya Rohit
Published: November 2023

Abstract: This research paper aims to analyze the role of artificial intelligence (AI) in cyber security threat detection and prevention. With the increasing sophistication and frequency of cyber-attacks, traditional security measures have become insufficient. AI has emerged as a promising solution to enhance cyber security by leveraging its capabilities in data analysis, pattern recognition, and anomaly detection. This paper explores the potential of AI in addressing cyber security challenges, examines existing literature, defines the problem statement, proposes a methodology, discusses the results, and concludes with future scope and recommendations.