bluuebunny/crossref_metadata_2025 huggingface dataset:
A pollináció mint ökoszisztéma-szolgáltatás vizsgálata Visnyeszéplak, Gyűrűfű és Magyarlukafa településeken
Authors: Prohászka Viola Judit , Tormáné Kovács Eszter , Saláta Dénes , Kollányi László , Sárospataki Miklós
Published: December 2023

Kutatásunk célja a Visnyeszéplak, Gyűrűfű és Magyarlukafa településeken található gyepek és a gyümölcsös alatti gyepek beporzóvizsgálata volt, amellyel a területek pollinációra vonatkozó ökoszisztéma-szolgáltatását kívántuk jellemezni. A beporzók felmérését 2021-2022-ben 3 alkalommal, településenként 3 fátlan gyepterületen és 3 gyümölcsös alatti gyepterületen végeztük a pollinátorok helyszínen történő megfigyelésével és feljegyzésével. Interjút összesen 8 méhésszel készítettünk 2020-2021-ben, mely során a méhészkedéssel és az ebből a szempontból fontos élőhelyekkel és növényfajokkal kapcsolatban tettünk fel kérdéseket, nagy hangsúlyt fektetve a méhlegelőkre és a méhlegelőnövény-fajokra. Vizsgálataink azt mutatták, hogy egyedszám tekintetében a fátlan gyepek összességében kiemelkedőbbek voltak, viszont taxonszám szempontjából a gyümölcsös alatti gyepek magasabb átlagértéket értek el. A falvakat összehasonlítva pedig mindkét típusú élőhelyre nézve az ökofalvak átlagértékei voltak magasabbak. Házi méhekre vonatkozóan a gyepek voltak kiemelkedőek, de a három falu összességében nem tért el egymástól (csupán egy alkalommal mértünk Magyarlukafán kimagasló egyedszámot). A méhészek nem voltak egységes véleményen a méhészetüket körülvevő méhlegelők minőségével kapcsolatban. Ugyanakkor többen elismerték, hogy az állóméhészetükhöz elengedhetetlenek azok az élőhelyek, amelyeken a kipergethető mézet adó növények ugyan nem fordulnak elő jelentős mennyiségben, de a méheknek táplálkozás szempontjából mégis szükségesek. Ilyen élőhelyeknek mondták az általunk vizsgált gyepeket is. Összességében elmondhatjuk, hogy a vizsgált ökofalvak jobb beporzókapacitással, és így jobb pollinációs ökoszisztéma-szolgáltatással rendelkeznek, mint a vizsgált nem ökofalu. Ugyanakkor módszertani kísérlet lévén az eredményeket érdemes finomítani, így hasonló vizsgálatok esetében javasoljuk a több mintavételi időpontban történő felvételezést, és a bővített statisztikai értékelést.
Sanar con amor
Authors: Constantino Karla Ivonne Moreno , Olivas Hernández Olga Lidia
Published: December 2023

En este artículo se analizan las experiencias corporizadas de sanación, espiritualidad y bienestar catalizadas por el consumo ritual de ayahuasca por parte de mujeres en la ciudad de Tijuana. La reterritorialización de la práctica ritual de ayahuasca da cuenta de su inserción en los circuitos de terapias alternativas que se organizan en la ciudad, y en los ensamblajes terapéutico-espirituales de las participantes. A partir de un estudio etnográfico en un centro de atención terapéutica, se describen las características del ritual de ayahuasca y a través de dos casos paradigmáticos se analizan las formas en que las participantes experimentan el bienestar y la sanación en las ceremonias con ayahuasca, a la cual refieren como una medicina que les permite sanar con amor. Se parte del estudio de los procesos de corporización vividos en el contexto ritual para discutir las experiencias desde las cuales las mujeres configuran procesos de autoconocimiento, bienestar y sanación.
Introducción - Religiones, espiritualidades y psicoactivos
Authors: Antunes Henrique Fernandes , Caicedo Fernández Alhena , Iamarino Caravita Rodrigo , Negrín Diana
Published: December 2023

Este dossier surgió de la necesidad de estimular un debate académico capaz de afrontar algunos de los principales debates contemporáneos sobre el tema que nos ocupa. Además, este dossier llena un vacío en el debate académico contemporáneo dentro de las ciencias sociales: la interfaz entre los fenómenos religiosos/espirituales y el uso de sustancias psicoactivas. Esto se analiza no sólo desde sus dimensiones cosmológicas y rituales, sino prestando atención, sobre todo, al debate de sus dimensiones más controvertidas que aparecen cuando los límites entre religión, ciencia y terapia pierden sus contornos definidos, cuando los estados nacionales comienzan a ver tales usos como un objeto de intervención estatal, y cuando los diversos grupos y usuarios se enfrentan a sus propias condiciones situadas de legalidad y legitimidad en disputa. A raíz de estas observaciones, prestamos especial atención a los momentos de tensión entre diferentes tipos de conocimiento, las estrategias de legitimación, la producción de clasificaciones y regulaciones, las economías emergentes y sus efectos, y la biopolítica desarrollada por las agencias estatales para regular o prohibir el uso de tales sustancias.
Signo de orejas del lince y paraparesia espástica hereditaria SPG11
Authors: Mattos-Castillo Jair , Sarapura-Castro Elison
Published: December 2023

Varón de 21 años, presenta trastorno de la marcha y del equilibrio lentamente progresivo desde los 17 años. Su hermano menor presenta síntomas similares. El examen neurológico mostró paraparesia espástica, hiperreflexia generalizada, reflejo plantar extensor bilateral y deterioro cognitivo moderado. HTLV I/II negativo, el estudio de neuroconducción reveló polineuropatía sensitivo-motora axonal. Se identificó mutación en el gen SPG11 en el probando y su hermano menor, mediante secuenciación de nueva generación (NGS). La RMN cerebral mostró el signo de "orejas de lince" y atrofia del cuerpo calloso. Este signo se correlaciona con la degeneración axonal del fórceps menor (cuerpo calloso) y su alta especificidad para la paraplejía espástica hereditaria tipo 11 y 15. Este signo (flechas amarillas) aparece hipointenso en T1 (1a) e hiperintensa en FLAIR (1b). La imagen 2 (flecha verde) muestra atrofia del cuerpo calloso donde el rostro, la rodilla y la parte media del cuerpo se ven más severamente afectadas.
The Continuity of Well Child and Chronic Disease Check Ups During Covid- 19 Pandemic and Comparison of Its Effect on Outpatient Visits in Early and Late Period
Authors: OZEN Gulsum , SARİCİ Dilek
Published: December 2023

Aim: Pandemic disrupted health care access in many centers all around the world. CDC recommended that seperating pandemic and non-pandemic hospitals, prioritizing emergency visits, postponing elective operations and, where possible, converting outpatient visits to telehealth calls. In this period, well-child checkups were cancelled and routine childhood vaccination was interrupted. We aimed to evaluate the impact of pandemic on the routine immunization schedule, neonatal screening program, chronic disease follow ups and outpatient clinic visits.

Material and Method: In total, 401 children and their parents were included in this study and patient population of interest was children of routine immunization age. Outpatient visit features and compliance with the childhood vaccination and neonatal screening program before and during the pandemic were asked.

Results: Compared to 2021, there was a significant increase in both the number of patients with upper respiratory tract infection symptoms and their hospital admissions. While the rates of hospital admissions increased in 2022 in those with diarrhea, almost all of the patients with lower respiratory tract infection symptoms stated that they applied to the hospital in both periods. It was observed that routine vaccination and newborn screening programs were carried out successfully during the pandemic process in Turkey. It was found that chronic disease follow-ups of children were interrupted in 2021.

Conclusion: This study has shown how the 3 major components of health system (outpatient clinic visits, well child check-ups and chronic disease follow-ups) were affected at different times of the pandemic in Turkey. Successful management in childhood vaccinations and neonatal screening program should also be ensured in chronic disease follow-up bythe separation of pandemic and non-pandemic hospitals. Showing the strengths and weaknesses of strategies implemented in health system during the pandemic guides the measures to be taken for similar situations that may occur in the future.
An In-Depth Analysis of Credit, Capital, and Operational Risks on Regional Development Banks' Performance Amidst the Covid-19 Pandemic
Authors: Sutrisno Sutrisno
Published: December 2023

The Covid-19 pandemic has hit the world since the end of 2019 and has damaged the world economy, including Indonesia. Banking as a financial institution that provides funding to companies is also affected. Because the pandemic has reduced the company's performance, and this decline in performance has had an impact on banking. The aim of this research is to test whether the Covid-19 pandemic has an impact on the relationship between risk factors and bank performance. Bank performance is measured by profitability which consists of return on assets (ROA) and return on equity (ROE), while bank risk in this study consists of credit risk, liquidity risk, capital, operational risk and the Covid-19 pandemic. The population in this research is the Regional Development Banks (BPD) in Indonesia totaling 34 banks with a sample of 30 banks. The observation period was 4 years with quarterly data so that 320 observation data were collected. Hypothesis testing uses panel data regression, and to select the best regression model, the model will be tested using the Chow-test, Hausman-test, and Lagrange Multiplier test. After the model test was carried out, the fixed effect model was selected as the best model. The research results show that credit risk and operational risk have a significant and negative influence on all profitability, both ROA and ROE. Meanwhile, liquidity risk (LDR) has no effect on both types of profitability, while capital has an effect on ROE but has no effect on ROA. Another interesting result is that the Covid-19 pandemic has no impact on the influence of risk on bank performance.
Viability of Nodule Bacteria Bradyrhizobium japonicummon Soybean Seeds by Treatment With Fungicides During Extended Storage
Authors: Vorobey Nadiya , Kukol Kateryna , Kots Sergii , Pukhtaievych Petro , Patyka Volodymyr
Published: December 2023

Background. With the increase in soybean cultivation areas, inoculants are becoming increasingly sought after. They are not only compatible with the original preparations for seed treatment of soybean but also offer the possibility of applying them for several days or even months before sowing into the soil.
Objective. The viability of new strains of nodule bacteria Bradyrhizobium japonicum (strain PC07 and strain B78) was investigated on the surface of soybean seeds treated with fungicides Fever and Maxim XL during the extended storage of inoculated seeds. Additionally, their ability for nitrogen fixation under symbiotic conditions was evaluated.
Methods. Сultivation, serial dilution method, determination of bacterial titer of inoculants, quantification of colony forming units (CFU), gas chromatography.
Results. In laboratory conditions, on the soybean seeds of Almaz and Vasylkivska varieties, the viability of the nodule bacteria B. japonicum PC07 and B78, which are more resistant to the active substances of these fungicides in pure culture, decreased. This reduction was dependent on the storage period, the fungicide used, and the strain of inoculant. One day after inoculation on the seeds without the use of fungicide, 68.6–75.4% CFU of the initial number was retained. Seeds treated with the fungicide Fever contained 36.5–38.3% CFU, and those treated with Maxim XL contained 26.2–27.0% CFU. The use of inoculants based on fungicide-resistant strains of B. japonicum PC07 and B78 also provided high cell viability – 2.41–2.8×106 (on the seeds without treatment), 1.40–1.70×106 (with Fever) and 0.8–1.17×106 (with Maxim XL) CFU/seed after 5 days of storage. The nitrogen-fixing activity of root nodules in soybean plants of Almaz and Vasylkivska varieties, whose seeds were treated with Fever, decreased on both varieties by 18.4–22.4% and 32.1–39.5%, respectively and for treatment with Maxim XL, the reduction was 24.5–33.7% and 47.7–75.2%, respectively, during the storage of seeds for 5 and 7 days before sowing, compared to control variants (seeds without fungicide treatment).
Conclusions. The utilization of fungicide-resistant strains of B. japonicum PC07 and B78 for bacterization of soybean seeds treated with fungicides Fever and Maxim XL provides a high inoculation titer during 5 days of storage. Viability of microbial cells on seeds treated with fungicides significantly diminishes during storage for more than 7–14 days. Insufficient titer of CFU of B. japonicum strains PC07 and B78 on the seed surface after 14 days of storage can considerably impede the efficacy of biopreparations. Therefore, it is crucial to seek substances that can enhance the resistance of rhizobia on seeds to the adverse effects of fungicide seed treatment, ensuring a longer period of their viability.
The Influence of Flavonoid Compositions on Nrf2 Transcription Factor Expression in Case of Infections Triggered by Influenza A Virus and Transmissible Gastroenteritis Coronavirus
Authors: Arkhypova Maryna , Deriabin Oleg , Trokhymchuk Tetiana , Starosyla Daria , Atamaniuk Viktor , Zavelevich Michael , Vialykh Zhanna , Rybalko Svitlana , Galkin Alexander
Published: December 2023

Background. Viral infections trigger transcription factors, including Nrf2, which regulate the expression of genes related to cytokines, chemokines, and more. Nuclear factor erythroid 2-related factor 2 (Nrf2) participates in complex regulatory networks controlling the expression of cytoprotective genes and immune responses. Recently, new roles have been attributed to Nrf2, including the regulation of antiviral responses.
Objective. The aim of the study was to analyze Nrf2 activation in influenza virus infection in vivo and in transmissible gastroenteritis coronavirus (TGEV) infection in vitro, as well as the effects of the flavonoid compositions Proteflazidum® and Protoil on the Nrf2 expression in these two experimental models of viral infection.
Methods. Outbred white mice were infected with influenza A virus (A/FM/1/47/H1N1 strain). Jurkat cells were infected with TGEV, previously adapted to these cells. Flavonoid compositions Proteflazidum® and Protoil (Ecopharm, Ukraine), containing the mixture of tricin, luteolin, apigenin, quercetin, and rhamnosin, were used in corresponding dilutions. Real-Time PCR was employed to analyze Nrf2 RNA expression in the lungs of mice and in both uninfected and virus-infected cells. Additionally, ELISA was used to assess the expression of Nrf2 peptide.
Results. The Nrf2 expression in the lungs of influenza virus-infected mice showed a tendency to increase within a 100-fold range. In virus-infected mice treated with Proteflazidum® or Protoil, the level of Nrf2 expression in the lungs decreased about 10-fold compared to infected untreated mice. TGEV infection resulted in 100-fold increase in Nrf2 expression in Jurkat cells. Both Proteflazidum® and Protoil decreased Nrf2 expression in TGEV-infected cells, while their effects on Nrf2 expression in the intact cells on Day 1 were not detected.
Conclusions. Flavonoid compositions have only a slight effect on Nrf2 expression in intact cells. However, in case of virus infection, both in vivo and in vitro, they counteract the extensive up-regulation of Nrf2 expression due to viral infection.
Wedge-tailed Eagles Aquila audax regularly sunning during a camera-monitoring survey
Authors:   Wildlife Queensland, Suite 1, Level 1, 30 Gladstone Road, Highgate Hill QLD 4101, Australia, Thomas Hannah ,   School of the Environment, University of Queensland, St Lucia QLD 4067, Australia,   Centre for Biodiversity and Conservation Science, University of Queensland, St Lucia QLD 4067, Australia
Published: December 2023

Two Wedge-tailed Eagles Aquila audax sunning were observed on images from a monitoring camera that was located at Flinders–Goolman Conservation Estate, in Ipswich Local Government Area, south-eastern Queensland. I observed the Eagles across multiple days in March–April 2023 whilst the camera was in place, despite the camera being unbaited, and originally positioned to detect Brush-tailed Rock-wallabies Petrogale penicillata. The images showed one adult, a pair of adults or an adult and a juvenile Eagle. This behaviour has been poorly documented in this species, although it has been widely observed in other bird species.
Radiation Damping Treated by Classicalization of Quantum Mechanics—Theoretical Issue of Cyclotron Radiation
Authors: Petrosky Tomio , Goto Yuki , Garmon Savannah
Published: December 2023

In this paper, we review a new treatment of classical radiation damping, which resolves a well-known contradiction in the Abraham-Lorentz equation that has long been a concern. This radiation damping problem has already been solved in quantum mechanics by the method introduced by Friedrichs. Based on Friedrichs’ treatment, we solved this long-standing problem by classicizing quantum mechanics by replacing the canonical commutation relation in quantum mechanics with the Poisson bracket relation in classical mechanics. As an application of our new approach, we will analyze the anomalous damping experienced by electrons undergoing cyclotron motion inside a waveguide near the cut-off frequency. This anomalous damping cannot be described using the existing Abraham-Lorentz equation.
ESP Lifted Oil Field: Basic Model for Control, and Comparison of Simulation Tools
Authors: Lie Bernt
Published: December 2023

Optimal operation of petroleum production is important in a transition from energy systems based on fossil fuel to sustainable systems. One sub-process in petroleum production deals with transport from the (subsea) well-bore to a topside separator. A simple model in [] of Electric Submersible Pump [ESP] lifted production was previously streamlined into a dynamic model suitable for illustration of the dynamics of oil transport, as well for control studies, with some comparison of two popular modeling languages: Modelica, and ModelingToolkit for Julia, []. Here, the discussion on dimensionless equipment models goes into more detail, and the comparison between Modelica and ModelingToolkit is significantly expanded upon with code comparison, numerical performance, and more experiments. Some added possibilities with ModelingToolkit and Julia wrt. sensitivity analysis and control design is included.
Enhancing View Synthesis with Depth-Guided Neural Radiance Fields and Improved Depth Completion
Authors: Wang Bojun , Zhang Danhong , Su Yixin , Zhang Huajun
Published: December 2023

Neural radiance fields (NeRF) leverage a neural representation to encode scenes, obtaining photo-realistic rendering of novel views. However, NeRF has notable limitations. A significant drawback is that it does not capture surface geometry and only renders the object surface colors. Furthermore, the training of NeRF is exceedingly time-consuming. We propose Depth-NeRF as a solution to these issues. Specifically, our approach employs a fast depth completion algorithm to denoise and complete the depth maps generated by RGB-D cameras. These improved depth maps guide the sampling points of NeRF to be distributed closer to the scene's surface, benefiting from dense depth information. Furthermore, we have optimized the network structure of NeRF and integrated depth information to constrain the optimization process, ensuring that the termination distribution of the ray is consistent with the scene’s geometry. Compared to NeRF, our method accelerates the training speed by 18% and significantly reduces the RMSE between the rendered scene depth and the ground truth depth, which indicates that our method can better capture the geometric information of the scene. With these improvements, we can train the NeRF model more efficiently and achieve more accurate rendering results.
A Design-Based Research Approach to Developing Teacher-Student Co-creation through Interactive E:books
Authors: Scott Howard , Smith Matthew
Published: December 2023

This paper outlines the evolution of a learning technology interface from a Beta version to launch with educators and its alignment to pedagogical theory, designed to maximise collaboration between teacher and student. It explores how the “co-creation” of curricula via textual sources that underpin teaching and learning can be enhanced through interactive e-books and outlines the challenges involved in this praxis. With a number of stakeholders involved in the live use of the platform (including teachers, students, HE educators, course instructors, curriculum designers and software developers), iterative feedback loops informed real-time design improvements to both the interface and the-ory. This collaboration utilised a design-based research (DBR) approach (Wang and Hannafin, 2005), which is outlined here as explanation of how the tool developed and how iterative feedback helped to reconsider the challenges educators face in implementing pedagogical innovation across differing contexts. We propose how speculative design (Lukens and DiSalvo, 2012) and Activity Theory (Engeström, 1987) workshops can methodologically enhance the planning and evaluation phases inherent to DBR approaches, which involve students to prepare for educators’ innovation. Finally, we conclude with how educators can utilise these design principles using stratified approaches to help prepare organisational approaches for innovation.
RUANG MENTAL DAN MODEL KOGNITIF IDEAL PEJABAT PEMERINTAH PADA HUMOR SATIRE #LORDLUHUT
Authors: Azizah Nurul
Published: December 2023

This research aims to (1) explain the relationship between the mental space of humor and #LordLuhut's satire; (2) describes the ideal concept of the idealized duties and authorities of government officials through the satire humor of #Lord Luhut. Citizen have the right to express their opinions and aspirations. There are many ways that can be done to convey the aspirations of a community to the government. One of them is by using social media to aspire their voice as a citizen. Criticism is conveyed through linguistic expressions on social media, one of which is manifested in satire humor. The data of this research is a form of humorous satire #LordLuhut which comes from various Twitter uploads. Data analysis was carried out qualitatively by using cognitive linguistic theories, such as mental space, profiling, prototypes and ideal cognitive models. The research results are presented with formal and informal methods. Several conclusions were obtained: (1) the existence of mental space in the expression of satire humor indicates that the expression is only imagination, not reality; (2) there is an ideal concept of a government official written by the author in the humorous satire #LordLuhut.

 
STRATEGI KETIDAKSANTUNAN BAHASA DALAM KALANGAN KOMUNITAS FACEBOOK DI MALAYSIA
Authors: Jeffry Mohd. Adam Fazery , Mansor Nor Shahila , Omar Siti Zobidah
Published: December 2023

This study focuses on the impoliteness strategies used in interactions among Facebook users in Malaysia. It is also scrutinized the perception of Malaysian netizens regarding the impoliteness strategies used in social media interactions. A mix of the qualitative descriptive and quantitative methods was employed. An approach of a qualitative descriptive is to comprised social interactions in the selected Facebook pages that contained the construction of impoliteness strategies. A total of 288 comments from netizens were selected, examined, and analyzed using the Impoliteness Strategies (Culpeper, 2011). The findings showed that there are various patterns of impoliteness strategies used, such as bald on record impoliteness, sarcasm, and inappropriate address forms. Whereas a quantitative approach involved a questionnaire that intended to determine the perception of netizens regarding the use of impoliteness strategies and factors that instigate the use of these strategies in social media interactions. Respondents consisted of 100 students aged between 18 to 35 years, randomly selected from public universities in Malaysia. The analysis of the questionnaires has shown that most respondents accept negatively the use of impoliteness strategies in social media interactions. Essentially the results of the questionnaire were inconsistent with the practicalities of the interaction on Facebook, which clearly demonstrated the widely used impoliteness strategy.
METHOD OF CONVERTING THE MONOLITHIC ARCHITECTURE OF A FRONT-END APPLICATION TO MICROFRONTENDS
Authors: Nikulina Olena , Khatsko Kyrylo
Published: December 2023

Web systems have existed for a long time and quite a lot of them have been created. Modern development uses new microservice architectural to improve performance, portability, and other important characteristics. This necessitates the transformation of legacy systems from a monolithic architecture to a microservices one. Such a process is complex and costly, so improving the methods for converting old systems to a new platform is relevant. This research aims to develop a method of applying microfrontends approach for monolithic single page applications (SPA). The article proposes a method of transforming the software system architecture from monolithic to microservice architecture (MSA). Since the client part of the system is considered, the term microfrontend is proposed, as an analog of microservers in the server part of the software systems. A brief review of existing architecture reengineering research is made and the advantages of a microservice approach are identified. The proposed three-stage method differs from the methods by the selection of an additional stage of conversion, which allows to gently change the connections between parts of the monolithic application, which were implemented in the initial monolithic architecture. The first stage is reverse engineering, it is proposed to shift the focus from the search for outdated code to the functional analysis of the program as such. The second stage, a transition to a modular architecture with the allocation of functionality into separate modules is proposed. At the end of the third stage, we have several separate programs (microinterfaces) that are connected to the main program. An experiment with a typical external SPA demonstrates the operation of the proposed algorithm. The system obtained as a result of the transformation is compared with the original one according to the following measurable parameters: production builds building time, size of the main bundle, and first page average load time. All comparisons showed the advantages of the system obtained as a result of the conversion. As a result, the architecture transformation algorithm allows you to obtain a guaranteed better result, taking into account the limitations of the interface SPA, which were not considered by the authors of previous articles.
Demonstração de dois teoremas sobre Sequências de Intervalos Encaixantes
Authors: Leite Afonso Henriques Silva , Françozo Rafael Verão
Published: December 2023

Em uma obra bastante utilizada no Ensino de Cálculo em Instituições de Ensino Superior no Brasil é feita uma referência à Propriedade dos Intervalos Encaixantes para se demonstrar a existência de raízes reais para uma equação quadrática, assim como para provar a existência de raizes para equações envolvendo potências quaisquer de incógnitas reais. Cita-se que se uma sequência de intervalos é encaixante então uma sequência formada com o quadrado ou com qualquer potência inteira de seus termos também é, muito embora não seja apresentada uma prova dessas alegações. Nesse trabalho, demonstra-se que se a Propriedade dos Intervalos Encaixantes vale para uma sequência de intervalos, então ela também vale para a sequência formada pelo quadrado ou qualquer potência inteira de seus termos. A prova é baseada na validade de duas Propriedades que fundamentam a Propriedade dos Intervalos Encaixantes e foi dividida em dois casos para incluir todas as possibilidades. A conclusão se baseia na dedução inferida a partir das provas das propriedades fundamentais, completando essa lacuna para melhor compreensão do assunto.
Partial Blue Light Blocking Glasses at Night Advanced Sleep Phase and Reduced Daytime Irritability but Did Not Alter Salivary Melatonin Secretion in Japanese Schoolchildren
Authors: Nishino Seiji , Maeda-Nishino Naoya , Yoshimoto Ryohei , Ono Taisuke , Chiba Shintaro
Published: December 2023

In modern society, delayed sleep patterns among schoolchildren present challenges to academic attendance and performance. The impact of nighttime light exposure, especially blue wavelength light, on sleep delay has long been acknowledged. We investigated the effects of using partial blue light blocking glasses (JINS Screen Lens Heavy [40% cut]) on salivary melatonin levels, sleep patterns, circadian phase, and daytime behavior in 39 male schoolchildren aged 10–12. Participants alternated between blue light blocking and standard clear lens glasses for three hours before bedtime, over two weeks in a crossover design, with a one-week washout interval. While blue light blocking glasses did not influence melatonin levels, they significantly advanced the sleep phase (bedtime: 22.03 ± 0.08h vs. 22.10 ± 0.1h, p < 0.05, sleep onset: 22.26 ± 0.08h vs. 22.36 ± 0.10h, p < 0.05). The effects were more pronounced in the second week and accompanied by improved irritability and reduced disruptive behavior. Blue light blocking glasses can advance sleep phase and improve behavior in schoolchildren, warranting further mechanistic investigation.
Enhancing Lead Ion Removal from Simulated Wastewater through Continuous Electrocoagulation Process: Investigating Operating Parameters and Adsorption Behavior
Authors: Ajjam Sata , Hlih Basheer , Alwan Hameed Hussein
Published: December 2023

Electrocoagulation, a promising method for the removal of contaminants from aqueous solutions, was investigated in this study. The effects of different operational parameters on the removal of lead ions were examined using a continuous electrocoagulation process in an 800 ml electrocoagulation cell. The experimental setup involved varying the hydraulic retention time (HRT) in intervals of 15, 25, 35, and 45 minutes, adjusting the applied voltage from 2 to 10 volts, manipulating the rotation speed at 0, 50, 100, and 150 rpm, and altering the distance between the electrodes at 2.3 and 2.7 cm. The initial concentration of lead ions in the aqueous solution was set at 200 mg Hg+2/L. The results revealed that an extended HRT significantly enhanced the removal efficiency of lead ions, with the maximum efficiency attained at a 45-minute HRT. Increasing the applied voltage up to 10 volts also improved the removal efficiency. However, as the distance between the electrodes increased, the removal efficiency decreased. Regarding the rotation speed, an increasing trend in removal efficiency was observed up to 100 rpm. Beyond this threshold, the removal efficiency gradually declined due to the destabilization of the formed flocs. Under optimal operating conditions, including a hydraulic retention time of 45 minutes, an applied voltage of 10 volts, a rotational velocity of 100 rpm, 2.3 cm between the electrodes, a lead concentration of 200 mg/l, and a pH of 7, a remarkable maximum removal efficiency of 97% was achieved. The electrodes utilized in the experiment were composed of aluminum/stainless steel (Al/St. St.).
The Combined Treatment with Ketogenic Diet and Metformin Slows Tumor Growth in Two Mouse Models of Triple Negative Breast Cancer
Authors: Schmidt Karen , Thatcher Amber , Grobe Albert , Hicks Linda , Gu Haiwei , Sears Dorothy D. , Ellies Lesley G. , Kalachev Leonid , Kroll Eugene
Published: December 2023

BACKGROUND
Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet their energetic and anabolic needs to fuel uncontrolled proliferation and metastasis. This glucose dependency is linked to a metabolic shift in response to hypoxic conditions.
METHODS
To leverage the glucose dependency of hypoxic tumor cells, we assessed the effects of a controlled reduction in systemic glucose by combining dietary carbohydrate restriction, using a ketogenic diet, with gluconeogenesis inhibition, using metformin, on two mouse models of triple-negative breast cancer (TNBC).
RESULTS
We confirmed that MET − 1 breast cancer cells require abnormally high glucose concentrations to survive in a hypoxic environment in vitro. Then, we showed that, compared to a ketogenic diet or metformin alone, animals treated with the combination regimen showed significantly lower tumor burden, higher tumor latency and slower tumor growth. As a result, lowering systemic glucose by this combined dietary and pharmacologic approach improved overall survival in our mouse model by 31 days, which is approximately equivalent to 3 human years.
CONCLUSION
This is the first preclinical study to demonstrate that reducing systemic glucose by combining a ketogenic diet and metformin significantly inhibits tumor proliferation and increases overall survival. Our findings suggest a possible treatment for a broad range of hypoxic and glycolytic tumor types, one that can also augment existing treatment options to improve patient outcomes.
Quality of life among patients with Sickle Cell Disease and their parents in Democratic Republic of Congo, qualitative study
Authors: ZIGASHANE Adrien BURUME , ONGEZI Emmanuel LURHANGIRHE , NYANGUNIA Nash MWANZA , OKITOTSHO Stanislas WEMBONYAMA , KAMBALE Richard MBUSA
Published: December 2023

Background
Sickle cells disease (SCD) is one of the most prevalent hemoglobinopathies. In Democratic Republic of Congo (DRC) Sickle cell disease is a serious public health issue aggravated by a limited access to health and social support. health and social support. SCD has an effect on individual overall well-being and quality of life. It has a negative impact on a patient's social life, schoolwork, physical and mental health, and career. In some cases, those who are impacted may have mental health conditions including grief, fear about dying, and denial of their illness.
Method
This qualitative study set out to assess the quality of life of children with SCD and their parents attending clinic ‘’Petite Clinique amis des enfants’’. For this study, we used in-depth interview.
Results
12 in-depth interviews were conducted including 7 parents of children with SCD and 5 teenagers’ patients. Five major interview themes emerged: (1) discovery circumstances, (2) Experience of sickle cell patients and/or their parents, (3) Repercussions of the disease in the lives of sickle cell patients, (4) Perceptions in relation to the disease, (5) cares issues and needs.
Conclusion
The findings point out the significance of creating culturally and locally relevant interventions to enhance access to healthcare, lower social and cultural barriers, foster better understanding of the disease, and integrate a model of routine follow-up for sickle cell patients, either in other secondary structures, which implies its integration within the DRC's health system.
A Novel Electromechanical System for Guide Vane Adjustment in a Small Turbine Test Rig
Authors: Kumar Sandeep , Gandhi Bhupendra K
Published: December 2023

A cost-effective and reliable electromechanical system for guide vane (GV) control is designed and developed, which is easy to install and operate for micro hydro and model turbine test rigs. The electromechanical system can hold the GVs against the forces of the flowing fluid. The GV control mechanism contains a two-phase permanent magnet synchronous motor (PMSM), field-oriented control, and a feedback mechanism to control current and speed. The transfer functions, algorithm, and working of PMSM by supervisory control and data acquisition are integrated with drivers written in C++. The validation of the model and prototype shows good agreement with a maximum deviation of 2.14% in unit discharge values. The GV operating mechanism is used to run the turbine at design and off-design operating conditions, and the corresponding flow field of the draft tube is analysed. The GVO of 34˚ is identified as a BEP condition that matches with the prototype's BEP condition. The maximum pressure pulsations are observed at 22.10˚ GVO, 63.70% of the BEP condition. The rotating vortex rope formed shows a normalised frequency of 0.284 with the normalised pressure fluctuations amplitude of 2 to 3 times.
Multi-modality Multi-task Model for mRS Prediction using Diffusion-weighted Resonance Imaging
Authors: Park In-Seo , Kim Seongheon , Jang Jae-Won , Park Sang-Won , Yeo Na-Young , Seo Soo Young , Jeon Inyeop , Shin Seung-Ho , Kim Yoon , Choi Hyun-Soo , Kim Chulho
Published: December 2023

This study focuses on predicting the prognosis of acute ischemic stroke patients with focal neurologic symptoms using a combination of diffusion-weighted magnetic resonance imaging (DWI) and clinical information. The primary outcome is a poor functional outcome defined by a modified Rankin Scale (mRS) score of 3-6 after 3 months of stroke. Employing nnUnet for DWI lesion segmentation, the study utilizes both multi-task and multi-modality methodologies, integrating DWI and clinical data for prognosis prediction. Integrating the two modalities was shown to improve performance by 0.04 compared to using DWI only. The model achieves notable performance metrics, with a dice score of 0.7375 for lesion segmentation and an area under the curve of 0.8065 for mRS prediction. These results surpass existing scoring systems, showing a 0.16 improvement over the Totaled Health Risks in Vascular Events score. The study further employs grad-class activation maps to identify critical brain regions influencing mRS scores. Analysis of the feature map reveals the efficacy of the multi-tasking nnUnet in predicting poor outcomes, providing insights into the interplay between DWI and clinical data. In conclusion, the integrated approach demonstrates significant advancements in prognosis prediction for cerebral infarction patients, offering a superior alternative to current scoring systems.
Clinical outcome of extended curettage with postoperative denosumab administration for the treatment of Campanacci Grade III giant cell tumors of the extremities
Authors: Zhang Shuai , Zhao JiaQi , Song Lei
Published: December 2023

Background
Management of Campanacci Grade III giant cell tumors of the extremities is controversial because wide resection with reconstruction results in a poor functional outcome for most patients. Denosumab has been used before operation to enable curettage and surgical downstaging in patients with giant cell tumor of bone (GCTB), where joint preservation is difficult. However, owing to osteosclerosis of the lesion and difficulty to curet the lesion thoroughly, preoperative denosumab treatment increases the local recurrence rate. It is unclear whether postoperative treatment with denosumab facilitate the ability of a joint to be salvaged by intralesional surgery instead of resection. Therefore, we performed a retrospective study to investigate the local recurrence rate, joint preservation status, and functional outcomes after extended curettage and postoperative denosumab treatment in Campanacci Grade III giant cell tumors of the extremities.
Methods
We retrospectively reviewed 23 patients with Campanacci Grade III GCTB of the extremities in our hospital from January 2017 to June 2023, who underwent extended curettage and postoperative denosumab administration alone, without preoperative denosumab treatment. Patients were followed for adverse events of denosumab, surgical outcome, limb function of lesions, and local recurrence following extended curettage with postoperative denosumab .
Results
All incisions were healed without deep infection and internal fixation failure. The mean age of the patients at surgery was 36.6 years, and the mean followup was 35.8 months ( range, 6–72 months). There of the 23 patients had local recurrence years postoperatively. The recurrence rate is 13.0%. Two was treated with repeat intralesional surgery with no additional recurrence 2 years later, and another was treated with en bloc resection and reconstruction with vascularised fibular graft. One patient had progression to knee osteoarthritis without oral analgesics. No patient had pulmonary metastases develop and malignant transformation of GCTB. The mean Musculoskeletal Tumor Society functional scores at last followup were 27.3 of 30 (range,25–29). No serious adverse events were detected due to denosumab.
Conclusion
Our observations suggest extended curettage with postoperative denosumab administration is a reasonable option for Campanacci Grade III giant cell tumors of the extremities. Extended curettage with adjuvant denosumab therapy resulted in beneficial surgical downstaging, including either a less morbid surgical procedure or delayed en bloc resection. Maybe, resection should be considered when structural integrity cannot be regained after bone grafting or bone cement filling combined with intemal fixation.
Genome-wide identification of WRKY genes in soybean and functional analysis of GmWRKY162-GmGSL7c in resistance to soybean mosaic virus
Authors: Zhao Zhihua , Wang Rongna , Su Weihua , Sun Tianjie , Wei Fengju , Yu Zhouliang , Xiao Fuming , Yan Long , Yang Chunyan , Zhang Jie , Wang Dongmei
Published: December 2023

Background Soybean mosaic disease caused by soybean mosaic virus (SMV) is one of the most devastating and widespread diseases in soybean producing areas worldwide. The WRKY transcription factors (TFs) are widely involved in plant development and stress responses. However, the roles of GmWRKY TFs in resistance to SMV infection are largely unclear.Results Here, a total of 185 GmWRKYs were identified from soybean (Glycine max), and were clustered into 3 groups and 7 subgroups. The characteristics, such as gene structure, conserved motifs, cis-regulatory elements, and selective pressure, were systematically analyzed. Furthermore, 60 GmWRKY genes were differentially expressed during SMV infection according to the transcriptome data. Among these genes, the expression of GmWRKY162 decreased after imidazole treatment in the incompatibility combination in soybean varieties Jidou 7 with SMV strain N3, which was confirmed by RT‒qPCR. Remarkably, the silencing of GmWRKY162 reduced callose deposition and enhanced virus spread during SMV infection. Next, EMSA and ChIP‒qPCR revealed that GmWRKY162 could directly bind to the promoter of GmGSL7c, which was reported to be involved in callose synthesis in our previous study.Conclusion Our study revealed that GmWRKY162 play a positive role in increasing callose deposition and suppressing virus spread during SMV infection by targeting GmGSL7c, which providing valuable insights into the roles of WRKY family genes in response to SMV and guidance for future studies in understanding virus-resistance mechanisms in soybean.
Risk and protective factors in the development of subthreshold anxiety during early adolescence
Authors: Chen Keyin , Li Qian , Zhang Jiayuan , Niu Lijing , Dai Haowei , Peng Lanxin , Wang Xingqin , Ma Qing , Zhang Ruibin
Published: December 2023

Background
Subthreshold anxiety (STA) is a significant risk factor for developing anxiety disorders (AX), especially during adolescence. Identifying the risk and protective factors in early life is crucial for early prevention and intervention. However, there is limited research on this topic among early adolescents.
Methods
We studied 11876 early adolescents from the Adolescent Brain and Cognitive Development (ABCD) Study to investigate factors influencing the evolution of STA from ages 9–10 to 12–13. Outcomes included developing AX, persistent STA, and recovery from STA. 786 participants were identified as STA using Child Behavior Checklist (CBCL). We incorporated 31 diathesis-stress-related variables as predictors, encompassing demographics, mental and physical health, and environment, and employed logistic regression for modeling STA transitions.
Results
Compared to HCs, adolescents with STA have a 6.93 odds ratio (OR) for converting to AX in three years. Risk factors for conversion include psychiatric family history, behavior inhibition, depression, sluggish cognitive tempo, oppositional defiance, and sleep disturbance. Those maintaining STA experience fewer risk factors like behavioral inhibition, depression, somatic problems, sleep disturbance, and family conflict. Recovery from STA is challenging with psychiatric family history, prodromal psychosis, depression, and sleep disturbance. Sensation seeking and lack of premeditation are protective against STA or transitioning to AX.
Conclusions
Various modifiable and non-modifiable factors were identified for prognosis of STA in early adolescence. Managing sleep routines, encouraging sensation seeking, and reducing premeditation could help prevent adverse outcomes. By targeting these modifiable factors, it becomes feasible to intervene and prevent adolescents at high risk early in life.
The evolution of organic material on Asteroid 162173 Ryugu and its delivery to Earth
Authors: Changela Hitesh , Kebukawa Yoko , Petera Lukas , Ferus Martin , Chatzitheodoridis Elias , Nejdl Lukas , Nebel Roman , Protiva Vaclav , Krepelka Pavel , Moravkova Jana , Holbova Radka , Hlavenkova Zuzana , Šamořil Tomáš , Yamashita Shohei , Takahashi Yoshio , Yada Toru , Nakato Aiko , Sobotkova Katerina , Tesarova Hana , Zapotok Dave
Published: December 2023

The recent return of samples from carbonaceous asteroids provides first insight into early Solar System prebiotic evolution from known planetary bodies. Asteroid 162173 Ryugu samples are CI (Ivuna type), the most water- and organic-rich chondritic material, composing mostly of phyllosilicate. This phyllosilicate surrounds micron to submicron macromolecular organic particles - insoluble organic matter. Alteration on 162173Ryugu evolved insoluble organic material into organic particles aromatic-richer than what is found in the lesser altered carbonaceous chondrite matrices, consistent with CI and type 1 carbonaceous chondrites. Wider-spread diffuse organic material is also preserved within the phyllosilicate, aliphatic-, carboxylic-richer and aromatic-poorer than the organic particles. This diffuse organic material is probably a mixture of both acid insoluble and solvent soluble organic molecules. Carboxyl/aromatic ratios in the diffuse organic matter of Ryugu are also characteristic of CI and type 1 carbonaceous chondrites, indicating the role of aqueous alteration in its formation. Some organic particles additionally evolved to completely surround phyllosilicate itself, meaning that the soluble organic bearing diffuse organic matter is contained within some of the macromolecular organic particles by aqueous alteration on Ryugu. Earth therefore was, and currently is, delivered micron-sized polymeric organic objects encapsulating biologically relevant molecules.
Boundedness of fractional sublinear operators on weightedgrand Herz-Morrey spaces with Variable Exponents
Authors: Yang zhenzhen Yang , Zhang WanJing Zhang , Zhang Jing Zhang
Published: December 2023

In this paper, our goal is to further introduce the weighted grand variableHerz-Morrey spaces and establish the boundedness of fractional sublinear operatorsand their multilinear commutators on the weighted grand variable Herz-Morrey s-paces. The results are still new even in the unweighted setting, which generalizes theprevious work of Wang et al. [17] and Zhang et al. [19].