bluuebunny/crossref_metadata_2025 huggingface dataset:
A semantic systems engineering framework for zero-defect engineering and operations in the continuous process industries
Authors: Cameron David B. , Waaler Arild , Fjøsna Erlend , Hole Monica , Psarommatis Foivos
Published: September 2022

The on-going twin transition demands that the continuous process industry builds and operates their facilities in a more sustainable way. This change affects the entire supply-chain. The market demands new ways of engineering, procuring and constructing plants that assure quality at each step of the process. Petroleum and petrochemical producers must reduce their waste and environmental footprint and find ways of migrating to sustainable production. There is zero tolerance for waste, emissions or process malfunctions. Engineering contractors need to transfer their skills to new processes and produce series, non-custom facilities for new applications like offshore wind energy, modular production and industrial symbiosis. This is leading to a convergence in methods with discrete manufacturing, especially the automotive industries. In this climate, this sector can benefit from applying Zero-defect Manufacturing (ZDM) to both engineering design and operations. This work defines a framework for implementing ZDM in the process industry supply chain. The framework brings together modelling techniques and models from the following disciplines: system engineering, computer-aided process engineering, automation (especially Industry 4.0) and semantic technologies. These contributions are synthesised into an information fabric that allows engineering firms to work in new ways. Operators and contractors can use the fabric to move from document-driven engineering to data-based processes. The fabric captures requirements and intent in design so that facilities can be delivered and started-up and operated with zero defects in the design and construction. The information is also a vital support for safe and efficient operations and maintenance. We call this zero-defect O&M. The framework combines a systems engineering break-down of facilities, based on ISO/IEC81346, with implementation in SysML, with semantic interoperability frameworks from the process industries (ISO15926). We build upon and synthesise the results of recent standardization initiatives from the industry, notably CFIHOS, DEXPI and READI. We draw on results from process systems engineering, the OntoCAPE ontology and the CAPE-OPEN standards. The framework is illustrated by application to a non-proprietary process system, namely the Tennessee-Eastman process. This example is used to show the modelling approach and indicate how the fabric supports zero-defect practices.
Blockage of neuromuscular glutamate receptors impairs reinnervation following nerve crush in adult mice
Authors: Personius Kirkwood E. , Siebert Danielle , Koch Dennis W. , Udin Susan B.
Published: September 2022

Motor axons in peripheral nerves are capable of regeneration following injury. However, complete recovery of motor function is rare, particularly when reinnervation is delayed. We have previously found that glutamate receptors play a crucial role in the successful innervation of muscle during mouse development. In particular, blocking N-methyl-D-aspartate (NMDA) receptor activity delays the normal elimination of excess innervation of each neuromuscular junction. Here, we use behavioral, immunohistochemical, electrophysiological, and calcium imaging methods to test whether glutamate receptors play a similar role in the transition from polyneuronal to mono-innervation and in recovery of function following peripheral nerve injury in mature muscle.
Effects of 12 weeks of Tai Chi Chuan intervention on the postural stability and self-reported instability in subjects with functional ankle instability: Study protocol for a randomized controlled trial
Authors: Ke Xiao-hua , Huang Dun-bing , Li Yin-yan , Li Xiao-mei , Guo Jin-hua , Guo Miao-miao , Yu Sheng-xian , Ma Sheng-chao , Jiang Cai , Lin Zhong-hua
Published: September 2022

Background

Tai Chi Chuan (TCC) is a physical activity modality that originated in China and is now widely popular around the world. Although there are a series of articles reporting that TCC can improve balance and other functional symptoms in a variety of populations, including the elderly, patients with stroke, and patients with Parkinson's disease, its efficiency has not been scientifically and methodically evaluated in subjects with functional ankle instability (FAI). Moreover, there is no literature directly comparing TCC and conventional balance training (CBT) interventions for FAI. The objective of this study is to investigate the comparative effects of TCC intervention and CBT protocols in improving postural balance and subjective instability feelings in patients with FAI.

Methods

This study will be a single-center, parallel group, randomized controlled trial. Sixty-eight patients with FAI will be included and randomly assigned in a 1:1 ratio to either an intervention group (n =34) or a control group (n = 34). The participants in the intervention group will complete 12 weeks of TCC intervention (40 min/time, 3 times/week for 12 weeks) on the basis of health education treatment. The control group will receive health education and 36 CBT sessions during a 12-week period. Outcome measures include postural stability and self-reported feelings of instability at baseline, after the end of the intervention, and 3-month follow-up. The postural stability assessment of patients with FAI will be detected by performing static and dynamic postural tests, which will be carried out through a specific balance platform (TecnoBody ProKin). Self-reported feelings of instability will be assessed by Cumberland Ankle Instability Tool (CAIT), American Orthopedics Foot and Ankle Society's Ankle–Hindfoot Evaluation Scale (AOFAS-AHES), and the MOS item Short Form Health Survey (SF-36).

Discussion

This trial will demonstrate whether a 12-week TCC intervention positively affects postural stability and self-reported outcomes in patients with FAI. At the same time, the superiority of its clinical efficacy will also be compared with that of CBT. This study may also help to redefine the value of traditional Chinese exercises in the treatment of chronic ankle instability.

Clinical trial registration

Chinese Clinical Trial Registry: ChiCTR2100041790. Registration date: 22 March 2021. http://www.chictr.org.cn/edit.aspx?pid=119501&htm=4.
Consensus clustering of gene expression profiles in peripheral blood of acute ischemic stroke patients
Authors: Yang Zhiyong , Wang Guanghui , Luo Nan , Tsang Chi Kwan , Huang Li'an
Published: September 2022

Acute ischemic stroke (AIS) is a primary cause of mortality and morbidity worldwide. Currently, no clinically approved immune intervention is available for AIS treatment, partly due to the lack of relevant patient classification based on the peripheral immunity status of patients with AIS. In this study, we adopted the consensus clustering approach to classify patients with AIS into molecular subgroups based on the transcriptomic profiles of peripheral blood, and we identified three distinct AIS molecular subgroups and 8 modules in each subgroup by the weighted gene co-expression network analysis. Remarkably, the pre-ranked gene set enrichment analysis revealed that the co-expression modules with subgroup I-specific signature genes significantly overlapped with the differentially expressed genes in AIS patients with hemorrhagic transformation (HT). With respect to subgroup II, exclusively male patients with decreased proteasome activity were identified. Intriguingly, the majority of subgroup III was composed of female patients who showed a comparatively lower level of AIS-induced immunosuppression (AIIS). In addition, we discovered a non-linear relationship between female age and subgroup-specific gene expression, suggesting a gender- and age-dependent alteration of peripheral immunity. Taken together, our novel AIS classification approach could facilitate immunomodulatory therapies, including the administration of gender-specific therapeutics, and attenuation of the risk of HT and AIIS after ischemic stroke.
Emergency medical service utilization among acute ischemic stroke patients in Beijing: An observational study
Authors: Ding Kexin , Chen Hui , Wang Yong , Liu Hongmei , Ceceke Bayier , Zhang Wei , Geng Ling , Deng Guifang , Sun Tao , Zhang Wenzhong , Wu Yiqun
Published: September 2022

Objective

To investigate emergency medical service (EMS) utilization and its associated factors in patients with acute ischemic stroke (AIS), and further explore the urban-rural differences.

Methods

Medical records for AIS in all emergency departments in Beijing were obtained from the Beijing Emergency Care Database from January 2018 to December 2021. EMS utilization was described and factors associated with EMS use were examined by multivariable logistic regression models with the generalized estimating equations. Results were compared between urban and rural districts.

Results

A total of 24,296 AIS patients were included in the analysis, and 11,190 (46.1%) were transported to hospitals by EMS. The percentage of EMS usage in urban areas was significantly higher than that in rural areas (53.6 vs. 34.4%, P < 0.001). From 2018 to 2021, EMS utilization was on the increase (P-value for trend <0.001) with a higher average annual growth rate in rural areas (12.6%) than in urban (6.4%). Factors associated with EMS utilization were age (OR: 1.20 per 10-year increase, 95% CI: 1.17–1.23), NIHSS scores, off-hour arrival (OR: 1.32, 95% CI: 1.23–1.37), treatment in tertiary hospitals (OR: 1.75, 95% CI: 1.60–1.92), and possessing comorbidities such as coronary artery disease (OR: 1.15, 95% CI: 1.17–1.24), atrial fibrillation (OR: 1.56, 95% CI: 1.41–1.73), prior stroke (OR: 0.84, 95% CI: 0.78-0.90) or dyslipidemia (OR: 0.78, 95% CI: 0.71–0.85).

Conclusion

This study demonstrated an inadequate use of EMS among AIS patients in Beijing, especially in rural areas, and revealed several associated factors. Enhanced education programs and EMS accessibility are necessary particularly for high-risk individuals and regions.
The plasma proteome is favorably modified by a high protein diet but not by additional resistance training in older adults: A 17-week randomized controlled trial
Authors: Franzke Bernhard , Bileck Andrea , Unterberger Sandra , Aschauer Rudolf , Zöhrer Patrick A. , Draxler Agnes , Strasser Eva-Maria , Wessner Barbara , Gerner Christopher , Wagner Karl-Heinz
Published: September 2022

Background

The age-related loss of muscle mass significantly contributes to the development of chronic diseases, loss of mobility and dependency on others, yet could be improved by an optimized lifestyle.

Objective

The goal of this randomized controlled trial was to compare the influence of a habitual diet (CON) with either a diet containing the recommended protein intake (RP) or a high protein intake (HP), both with and without strength training, on the plasma proteome in older adults.

Methods

One hundred and thirty-six women and men (65–85 years) were randomly assigned to three intervention groups. CON continued their habitual diet; participants of the HP and RP group consumed either high protein or standard foods. After 6 weeks of dietary intervention, HP and RP groups additionally started a strength training intervention twice per week for 8 weeks. Twenty-four hours dietary recalls were performed every 7–10 days. Body composition was assessed and blood taken. Plasma proteomics were assessed with LC-MS.

Results

Participants of the HP group doubled their baseline protein intake from 0.80 ± 0.31 to 1.63 ± 0.36 g/kg BW/d; RP increased protein intake from 0.89 ± 0.28 to 1.06 ± 0.26 g/kg BW/d. The CON group kept the protein intake stable throughout the study. Combined exercise and HP initiated notable changes, resulting in a reduction in bodyfat and increased muscle mass. Proteomics analyses revealed 14 significantly affected proteins by HP diet, regulating innate immune system, lipid transport and blood coagulation, yet the additional strength training did not elicit further changes.

Conclusions

Combined HP and resistance exercise in healthy older adults seem to induce favorable changes in the body composition. Changes in the plasma proteome due to the high protein diet point to a beneficial impact for the innate immune system, lipid transport and blood coagulation system, all of which are involved in chronic disease development.

Clinical trial registration

The study was registered at ClinicalTrials.gov (NCT04023513).
Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia
Authors: Hernaningsih Yetti , Syafitri Yuli , Indrasari Yulia Nadar , Rahmawan Prafa Alif , Andarsini Mia Ratwita , Lesmana Indra , Moses Emmanuel Jairaj , Abdul Rahim Nur Arzuar , Yusoff Narazah Mohd
Published: September 2022

Background

The frequency of the beta-thalassemia (β-thalassemia) gene in Indonesia ranges from 3 to 10%. However, in the East Java province, there is still limited information on the prevalence of β-thalassemia mutations in clinically diagnosed beta-thalassemia patients of East Java. Therefore, this study aimed to characterize β-thalassemia mutations in selected patients in the East Java province of Indonesia.

Methods

This is an analytical observational study. Diagnosis of β-thalassemia was based on clinical presentation, complete blood count (CBC), and hemoglobin (Hb) electrophoresis. Blood specimens taken from each patient in three ethylenediaminetetraacetic acid (EDTA) tubes were analyzed for CBC and Hb electrophoresis and processed for DNA extraction and subsequent polymerase chain reaction (PCR). Detection of mutations in Hemoglobin Subunit Beta (HBB) gene exons 1–3 of the β-thalassemia gene as the common mutation in Indonesia was done using PCR followed by Sanger sequencing.

Results

In total, 33 (n = 33) participants were involved in this study with ages ranging from 5 to 17 years comprising 19 women and 14 men. Their ethnic origins were Javanese (n = 30) and Chinese (n = 3). CBC results showed that mean ± standard deviation (SD) for Hb, red blood cell (RBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW)-CV were 81.2 ± 7.0 g/L; 3.40 ± 0.39 × 109/L; 71.05 ± 5.72 fL; 24.12 ± 2.45 pg; 33.91 ± 1.47 g/dl; 24.38 ± 6.02%, respectively. Hb electrophoresis revealed that 5 out of 33 participants had beta-thalassemia and 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia. Results of Sanger sequencing showed the following genotype variations in the samples: 12 (36.4%) with βCD26/βIVS−I−5; 6 (18.2%) with βCD26/βCD35; 3 (9.1%) with βCD26/βIVS−I−2; 2 (6.1%) with βCD27/28/βCD40; 2 (6.1%) with βIVS−I−1/βCAP+1; and βCD26/βIVS−I−1; βIVS−I−5/βCAP+1; βIVS−I−5/βCD35; βCD26/βCD37; βCD26/βCD15; βCD26/βCD40; and βIVS−I−5/βCD19 in 1 (3%) sample, respectively, and 1 (3%) had no abnormality detected in sequencing even though electrophoresis showed abnormality in the migration pattern. The βCD26/βIVS−I−5 mutation was found in samples that were noted to have Hb E/beta-thalassemia on Hb electrophoresis.

Conclusion

The underlying genetic variations are heterogeneous in thalassemia patients in East Java, where 12 variants were found. The most common variant was βCD26/βIVS−I−5, which all accounted for Hb E/beta-thalassemia on Hb electrophoresis. Furthermore, 28 out of 33 participants had hemoglobinopathy (Hb) E/beta-thalassemia.
Pleiotropic effects of recombinant protease inhibitors in plants
Authors: Mangena Phetole
Published: September 2022

Recombinant gene encoded protease inhibitors have been identified as some of the most effective antidigestive molecules to guard against proteolysis of essential proteins and plant attacking proteases from herbivorous pests and pathogenic microorganisms. Protease inhibitors (PIs) can be over expressed in transgenic plants to complement internal host defense systems, Bt toxins in genetically modified pest resistance and abiotic stress tolerance achieved through cystatins expression. Although the understanding of the role of proteolytic enzymes and their inhibitors encoded by both endogenous and transgenes expressed in crop plants has significantly advanced, their implication in biological systems still requires further elucidations. This paper, therefore, succinctly reviewed most recently published literature on recombinant proteases inhibitors (RPIs), focusing mainly on their unintended consequences in plants, other living organisms, and the environment. The review discusses major negative and unintended effects of RPIs involving the inhibitors’ non-specificity on protease enzymes, non-target organisms and ubiquitous versatility in their mechanism of inhibition. The paper also discusses some direct and indirect effects of RPIs such as degradation by distinct classes of proteases, reduced functionality due to plant exposure to severe environmental stress and any other potential negative influences exerted on both the host plant as well as the environment. These pleiotropic effects must be decisively monitored to eliminate and prevent any potential adverse effects that transgenic plants carrying recombinant inhibitor genes may have on non-target organisms and biodiversity.
Differences in visual search behavior between expert and novice team sports athletes: A systematic review with meta-analysis
Authors: Silva Ana Filipa , Afonso José , Sampaio António , Pimenta Nuno , Lima Ricardo Franco , Castro Henrique de Oliveira , Ramirez-Campillo Rodrigo , Teoldo Israel , Sarmento Hugo , González Fernández Francisco , Kaczmarek Agnieszka , Oniszczuk Anna , Murawska-Ciałowicz Eugenia
Published: September 2022

Background

For a long time, in sports, researchers have tried to understand an expert by comparing them with novices, raising the doubts if the visual search characteristics distinguish experts from novices. Therefore, the aim of the present study was to review and conduct a meta-analysis to evaluate the differences in visual search behavior between experts and novices in team sports athletes.

Methods

This systematic review with meta-analysis followed the PRISMA 2020 and Cochrane's guidelines. Healthy team athletes were included, which engaged in regular practice, from any sex or competitive level, specifically classified a priori as expert or novice in the original research (i.e., if they were classified after the experiment, based on one of the tests, the study would be excluded). We considered only research published in peer-reviewed journals, with no limitations regarding date or language. It was considered healthy team sport athletes engaged in regular practice. The scenarios could be in situ or film-based. The databases of EBSCO (Academic Search Complete, Academic Search Ultimate, APA PsycArticles, and APA PsycINFO), PubMed, Scopus, SPORTDiscus, and Web of Science were used to perform the searches. The risk of bias was calculated through the RoBANS tool.

Results

From a total of 6,257 records, of which 985 were duplicates, titles and abstracts of 5,272 were screened, and 45 required full-text analysis. Of those, 23 were excluded due to not fulfilling the eligibility criteria regarding participants. In the end, 22 studies were selected, however, as two studies were part of the same trial and were analyzed conjointly.

Discussion

Experts showed to be older and with more years of practice. The ability to distinguish experts from novices was not so clear regarding the variables analyzed. This could be due to the strategies chosen in each study, which were specific to each scenario, and when grouping all together, it was lost information within non-representative averages. The distinction between experts and novices was not clear, showing a lot of heterogeneity in the included studies. The expert classification itself may have been the conditioning aspect for these results, retaining the doubt and the need for more studies in the field.

Systematic review registration

The protocol was pre-registered in OSF (project https://osf.io/3j4qv/, register https://osf.io/dvk2n).
The reciprocal relationship between mathematics self-efficacy and mathematics performance in US high school students: Instrumental variables estimates and gender differences
Authors: Sakellariou Chris
Published: September 2022

Objective

To investigate the reciprocal relationship between high school students’ academic self-efficacy and achievement in mathematics using US data from the HSLS:2009 and first follow-up longitudinal surveys, while accounting for biases in effect estimates due to unobserved heterogeneity.

Methods

Instrumental Variables (IV) regressions were estimated, to derive causal effect estimates of earlier math self-efficacy on later math achievement and vice versa. Particular attention was paid to testing the validity of instruments used. Models were estimated separately by gender, to uncover gender differences in effects.

Results

Evidence of robust reciprocal effects between self-efficacy and achievement for male students is presented, with the dominant effect from earlier achievement to later self-efficacy. For girls, evidence of such effects is weak. Generally, IV estimates are higher than OLS estimates for males, but not for females. As opposed to earlier correlational studies which did not find significant gender differences despite theoretical expectations for their existence, the findings support higher effects for male students.
Early Detection of College Students' Psychological Problems Based on Decision Tree Model
Authors: Huang Yunpeng , Li Shaoan , Lin Bo , Ma Shuai , Guo Jian , Wang Chunli
Published: September 2022

The paper starts with the research on the early discovery of college students' psychological problems. Besides, it analyzes the data of the general survey of college students' mental health in a certain university, the existing data of students with psychological problems, and the questionnaire data of students' basic information in school. By comprehensively using the decision tree model and Kendall correlation analysis and other methods, using Python and SPSS software to preprocess the data and realize the model, it can obtain a psychological problem prediction model based on the objective behavior data of college students. The model is actually analyzed, and it gets good results.
Development of the short Creative Expression Interest Scale based on item response theory
Authors: Zhao Peng Juan , Gao Xu Liang , Zhao Nan , Luo Zhao Sheng
Published: September 2022

This study develops a short Creative Expression Interest Scale (CEIS) among Chinese freshmen based on the perspective of item response theory (IRT). Nine hundred fifty-nine valid Chinese freshmen participated in the Creative Expression Interest survey. Researchers applied the initial data for unidimensionality, item fit, discrimination parameter, and differential item functioning to obtain a short CEIS. The results show that the Short CEIS meets the psychometric requirements of the IRT. Pearson correlation coefficient of theta between the short and long CEIS is 0.922. The marginal reliability of the short CEIS is 0.799. These indicate that the short CEIS developed in this study among Chinese freshmen, meets the psychometric requirements. Although the Short CEIS can eliminate redundant, uninformative items, save time, and improve the quality of data collection. However, the validity of this short scale needs further validation.
Needs-based off-job crafting across different life domains and contexts: Testing a novel conceptual and measurement approach
Authors: Kujanpää Miika , Syrek Christine , Tay Louis , Kinnunen Ulla , Mäkikangas Anne , Shimazu Akihito , Wiese Christopher W. , Brauchli Rebecca , Bauer Georg F. , Kerksieck Philipp , Toyama Hiroyuki , de Bloom Jessica
Published: September 2022

Shaping off-job life is becoming increasingly important for workers to increase and maintain their optimal functioning (i.e., feeling and performing well). Proactively shaping the job domain (referred to as job crafting) has been extensively studied, but crafting in the off-job domain has received markedly less research attention. Based on theIntegrative Needs Model of Crafting, needs-based off-job crafting is defined as workers’ proactive and self-initiated changes in their off-job lives, which target psychological needs satisfaction. Off-job crafting is posited as a possible means for workers to fulfill their needs and enhance well-being and performance over time. We developed a new scale to measure off-job crafting and examined its relationships to optimal functioning in different work contexts in different regions around the world (the United States, Germany, Austria, Switzerland, Finland, Japan, and the United Kingdom). Furthermore, we examined the criterion, convergent, incremental, discriminant, and structural validity evidence of the Needs-based Off-job Crafting Scale using multiple methods (longitudinal and cross-sectional survey studies, an “example generation”-task). The results showed that off-job crafting was related to optimal functioning over time, especially in the off-job domain but also in the job domain. Moreover, the novel off-job crafting scale had good convergent and discriminant validity, internal consistency, and test–retest reliability. To conclude, our series of studies in various countries show that off-job crafting can enhance optimal functioning in different life domains and support people in performing their duties sustainably. Therefore, shaping off-job life may be beneficial in an intensified and continually changing and challenging working life.
Are you a spontaneous traveler? Effect of sensation seeking on tourist planfulness in the mobile era
Authors: Li Qiuyun , Xu Hong , Hu Yubei
Published: September 2022

Drawn upon optimum stimulation level theory, and in view of the impact of mobile terminal usage on tourist decision-making, the present study aims to investigate how personality (i.e., sensation seeking) influences tourist trip planning behavior (i.e., tourist planfulness) in the mobile era. A sample of 344 respondents in China completed measures of sensation seeking, travel risk perception, smartphone usage, as well as tourist planfulness. Results indicated that sensation seeking was negatively associated with tourist planfulness and travel risk perception partially mediated this association. Besides, both the direct effect of sensation seeking on tourist planfulness and the indirect effect of travel risk perception were moderated by smartphone usage, in that these effects were stronger for tourists with a high-level of smartphone usage than those with low-level smartphone usage. This study can significantly advance existing research on tourist behavior from the perspective of personality and reconfiguring our traditional understanding on tourist decision-making in the mobile era. Our study may also provide indicative support for theoretical perspective that information technology is changing customer behavior.
Lexical simplification benchmarks for English, Portuguese, and Spanish
Authors: Štajner Sanja , Ferrés Daniel , Shardlow Matthew , North Kai , Zampieri Marcos , Saggion Horacio
Published: September 2022

Even in highly-developed countries, as many as 15–30% of the population can only understand texts written using a basic vocabulary. Their understanding of everyday texts is limited, which prevents them from taking an active role in society and making informed decisions regarding healthcare, legal representation, or democratic choice. Lexical simplification is a natural language processing task that aims to make text understandable to everyone by replacing complex vocabulary and expressions with simpler ones, while preserving the original meaning. It has attracted considerable attention in the last 20 years, and fully automatic lexical simplification systems have been proposed for various languages. The main obstacle for the progress of the field is the absence of high-quality datasets for building and evaluating lexical simplification systems. In this study, we present a new benchmark dataset for lexical simplification in English, Spanish, and (Brazilian) Portuguese, and provide details about data selection and annotation procedures, to enable compilation of comparable datasets in other languages and domains. As the first multilingual lexical simplification dataset, where instances in all three languages were selected and annotated using comparable procedures, this is the first dataset that offers a direct comparison of lexical simplification systems for three languages. To showcase the usability of the dataset, we adapt two state-of-the-art lexical simplification systems with differing architectures (neural vs. non-neural) to all three languages (English, Spanish, and Brazilian Portuguese) and evaluate their performances on our new dataset. For a fairer comparison, we use several evaluation measures which capture varied aspects of the systems' efficacy, and discuss their strengths and weaknesses. We find that a state-of-the-art neural lexical simplification system outperforms a state-of-the-art non-neural lexical simplification system in all three languages, according to all evaluation measures. More importantly, we find that the state-of-the-art neural lexical simplification systems perform significantly better for English than for Spanish and Portuguese, thus posing a question if such an architecture can be used for successful lexical simplification in other languages, especially the low-resourced ones.
Property as the law of virtual things
Authors: Fairfield Joshua
Published: September 2022

Property law in the twentieth century moved from the law of things to the law of rights in things. This was a process of fragmentation: Under Hohfeldian property, we conceive of property as a bundle of sticks, and those sticks can be moved to different holders; the right to possess can be separated from the record ownership right, for example. The downside of Hohfeld's model is that physical objects—things—become informationally complicated. Thing-ness constrains the extravagances of Hohfeldian property: although we can split off the right to possess from the right to exclude, use, destroy, copy, manage, repair, and so on, there is a gravitational pull to tie these sticks back into a useful bundle centered on the asset, the thing. Correspondingly, there has been an “informational turn” to property law, looking at the ways in which property law serves to limit property forms to reduce search costs, and to identify and celebrate the informational characteristics of thing-ness. The question of thing-ness came to a head in the context of digital and smart assets with the formation of non-fungible tokens. NFTs were attempts to generate and sell “things,” a conceptually coherent something that can contain a loose bundle of rights. The project was an attempt to re-create thing-ness by an amalgam of cryptography, game theory, and intellectual property. This essay discusses thing-ness in the context of digital assets, how simulated thing-ness differs from physical thing-ness, and the problems that arise from attempts to reify digital assets.
Salivary biomarkers as key to monitor personalized oral healthcare and precision dentistry: A scoping review
Authors: Paqué Pune Nina , Hjerppe Jenni , Zuercher Anina N. , Jung Ronald E. , Joda Tim
Published: September 2022

Personalized Oral Healthcare has recently become the new trend word in medicine and dentistry. In this context, saliva diagnostics using various biomarkers seem to be the gateway to personalized dental diagnostics and therapy. But the terminology is not (yet) uniformly defined, furthermore it is unclear to what extent which salivary markers play a relevant role in the therapeutic decision making. In this Scoping Review, an electronic search was conducted in PubMed and Web of Science databases using medical subject headings (MESH terms) “saliva”, “biomarker”, “personality/persons”, and “dentistry”. Only human studies were included, in which repeated salivary measurements were performed to analyze monitoring effects with at least ten patients per group. PRISMA-ScR and Tricco guidelines were followed: (i) to examine what salivary biomarkers have been explored in terms of personalized oral healthcare and precision dentistry, (ii) to investigate the clinical relevance for oral health and its correlation to systemic health, and (iii) to summarize an outlook for future developments based on these results. Out of 899 studies, a total of 57 were included for data extraction in this Scoping Review, mainly focusing on periodontal therapy and patient monitoring. Salivary biomarkers have shown the potential to change the field of dentistry in all dental disciplines as a key for personalized workflows. The increasing interest in dental research is obvious, demonstrated by the growing number of publications in recent years. At this time, however, the predominant discipline is periodontology, which allows biomarker-based monitoring of the disease prevention and progression. The studies included showed heterogeneous methods using manifolds biomarkers. Therefore, no uniformly accepted concept can be presented today. Further clinical research with well-defined outcomes including standardized procedures is necessary.
Case report: Resection of a massive primary sacrococcygeal mature teratoma in an adult using 3-dimensional reconstruction and mixed reality technology
Authors: Zhang He , Ji Lu , Liu Jinxin , Li Shizhe , Chen Ting , Li Jiatong , Shang Guanning
Published: September 2022

Introduction

Teratomas are rare neoplasms that arise from pluripotent germ cells. Sacrococcygeal teratomas are often diagnosed in infants but are rare in adults; a mature teratoma can contain hair, teeth, bony tissue, and other mature tissue types. Herein, we report for the first time a patient with a teratoma containing intact bones that formed a pseudoarthrosis.

Case report

A 49-year-old woman was admitted to hospital after a massive life-long sciatic tumor had begun to grow larger over the past year. A 16 cm × 25 cm solid mass with a clear boundary was palpable in the sacrococcygeal region. Radiography, computed tomography, and magnetic resonance imaging indicated a sacrococcygeal teratoma, although blood alpha-fetoprotein levels were normal. The teratoma was completely excised using 3-dimensional reconstruction mixed reality (MR) technology with no notable complications. Postoperative pathological examination of the excised lesion confirmed a mature teratoma. Interestingly, two intact irregular bones that formed a pseudoarthrosis were isolated; one was 11 cm and the other 6 cm. The patient is currently healthy and has experienced no recurrences.

Conclusion

Sacrococcygeal teratomas are rare, especially in adults, and often comprised lots of components, such as fat, bony tissue. However, it's first reported that formation of pseudoarthrosis in this case so far. It is difficult for surgeons to achieve complete excision without complications owing to the complex anatomic structure of the sacrum. The 3-dimensional reconstruction and mixed reality (MR) technology based on computed tomography can provide spatial visualization, which allows surgeons to examine the teratoma at different angles preoperatively. Combining 3-dimensional reconstruction and mixed reality (MR) technology in this case facilitated complete resection and prevented recurrence.
Clinical application of endoscopic surgery using a gasless unilateral transaxillary approach in the treatment of primary hyperparathyroidism
Authors: Zhang Wan-Chen , Lu Dong-Ning , Xu Jia-Jie , Guo Hai-Wei , Ge Ming-Hua , Zheng Chuan-Ming
Published: September 2022

Objectives

To investigate the safety and feasibility of gasless axillary parathyroid surgery in the treatment of primary hyperparathyroidism.

Methods

A total of 12 patients who received gasless axillary parathyroidectomy (endoscope group) and 14 patients who received traditional open parathyroidectomy (open group) from January 2019 to April 2022 were screened and included. The differences in baseline characteristics, surgical efficiency, incidence rate of complications, changes in biochemical indicators, and incision satisfaction between the two groups were analyzed and compared.

Results

The proportion of young patients was higher in the endoscopic group than in the open group, and the difference was statistically significant [(41.33 ± 13.65) years vs. (58.00 ± 9.44) years, P < 0.01]. The differences in operation time, intra-operative blood loss, post-operative drainage volume, hospital stay, and surgical efficiency between the two groups yielded no statistical significance (P > 0.05). Patients in the open group had more significant neck pain 3 days after surgery (P = 0.046), but the degree of pain 3 months after surgery was the same in the 2 groups (P = 0.432). Evaluation of post-operative mature stage scar and incision satisfaction regarding aesthetics in the endoscope group were significantly superior to that in the open group [(1.92 ± 0.92) points vs. (0.92 ± 1.00) points, P = 0.017 and (1.57 ± 0.51) points vs. (1.00 ± 0.013) points, P = 0.013, respectively]. No statistical significance was found in terms of incidence rate of post-operative fever (P > 0.05). No temporary recurrent laryngeal nerve injury, post-operative bleeding, incision hematoma infection, or other complications were observed. Comparing the two groups, the extent of the level decrease of PTH was similar to that of serum calcium and phosphorus (P < 0.05), where most patients experienced transient hypocalcemia after operation yielding no significant difference in incidence (P = 0.225). During a follow-up period of 3 to 36 months, a total of 1 patient in the open group experienced recurrence at 10 months after surgery and was treated non-surgically.

Conclusion

Gasless axillary approach to parathyroid surgery for primary hyperparathyroidism possesses good safety and patient satisfaction in terms of aesthetics.
Internet Survey Evaluation of Iliopsoas Injury in Dogs Participating in Agility Competitions
Authors: Fry Lindsey M. , Kieves Nina R. , Shoben Abigail B. , Rychel Jessica K. , Pechette Markley Arielle
Published: September 2022

Objective

To describe risk factors associated with demographics, training, and competition for iliopsoas injury in dogs participating in agility competitions, as well as describe owner reported treatment and return to sport following injury.

Procedures

An internet-based survey of agility handlers collected risk factor data for dogs participating in agility. Owners were asked questions about demographics, training, and competition as well as injury treatment and recovery if applicable. Associations between variables of interest and iliopsoas injury were estimated with logistic regression. The final risk factor model was built via modified backward selection, with all variables in the final model showing significant associations at p < 0.05.

Results

Of the 4,197 dogs in the sample, 327 (7.8%) reported iliopsoas injury. The final model identified six risk factors for iliopsoas injury. A higher risk of iliopsoas injury was observed for the Border Collie breed, dogs with handlers who are veterinary assistants, dogs competing on dirt, dogs competing on artificial turf 6+ times a year, and dogs that trained with the 2 × 2 method for weave poles. Dogs that were not acquired with agility in mind were observed to have a decreased risk of injury. Factors like number of competition days and jump height were not significantly associated with risk of iliopsoas injury. Owners sought veterinary care for 88% of dogs with iliopsoas injury, including specialty care for 63%. Treatment most often included rest, home rehabilitation, formal rehabilitation, and/or oral medications. Most dogs (80%) were able to return to sport within 6 months, while 20% were out for longer than 6 months, or retired.

Conclusion and Clinical Relevance

Iliopsoas injury can necessitate a significant amount of time off from training and competition, and even lead to retirement of dogs competing in agility. Some of the risk factors identified in this study can inherently not be modified (breed, intended use, and handler profession), but can be taken into consideration for injury prevention strategies. Competition and training risk factors that can be modified, such as weave training, may help to inform guidelines for best practices in management of the agility athlete.
Defective Subviral Particles Modify Ecological Equilibria and Enhance Viral Coexistence
Authors: Lucia-Sanz Adriana , Aguirre Jacobo , Fraile Aurora , García-Arenal Fernando , Manrubia Susanna
Published: September 2022

Cooperation is a main driver of biological complexity at all levels. In the viral world, gene sharing among viral genomes, complementation between genomes or interactions within quasispecies are frequently observed. In this contribution, we explore the effects of flexible associations between fully fledged viruses and subviral entities, such as virus satellites, in viral dynamics and, in particular, in stable viral coexistence. We devise a mathematical model to compare different situations of competition between two viruses and to quantify how the association with a satellite qualitatively modifies dynamical equilibria. The relevant parameter is the invasion fitness of each virus or of the virus-satellite tandem, which in the model depends on the transmission rate of viruses and on their effect on host survival. In a virus-virus competition, one of the viruses becomes eventually extinct, recasting the competitive exclusion law of ecology. However, an association with a satellite might change the outcome of the competition in two ways, either to favor the less competitive virus (regardless of whether it is the helper virus or not) or to allow for the stable coexistence of the two viruses and the satellite. The virus-satellite association differs from other mechanisms proposed in ecology to date to enhance species coexistence. We hypothesize that such an association constitutes a parsimonious evolutionary pathway towards more stable cooperative associations, such as bipartite viral forms, a collaborative association unique to viruses.
Implementation and Real-Time Validation of a European Remain Well Clear Function for Unmanned Vehicles
Authors: Corraro Gianluca , Corraro Federico , Ciniglio Umberto , Filippone Edoardo , Peinecke Niklas , Theunissen Erik
Published: September 2022

The full integration of Remotely Piloted unmanned vehicles into civil airspace requires first and foremost the integration of a traffic Detect and Avoid (DAA) system into the vehicle. The DAA system supports remote pilots in performing their task of remaining Well Clear from other aircraft and avoiding collisions. Several studies related to the design of a Remain Well Clear function have been performed that served as input for the development of technical standards applicable to non-European countries. In this paper, a Remain Well Clear implementation is proposed that, using the results of past international projects, fits European airspace needs and specificities and can be acceptable to both remote pilots and air traffic controllers, with only minimal impact on the standard operating procedures used for manned aircraft. The proposed Remain Well Clear software has been successfully validated through real-time simulations with pilots and controllers in the loop considering traffic encounters and mission scenarios typically found in European airspace. The achieved results highlight the appropriate situational awareness provided by the proposed RWC function and its effective support to the remote pilot in making adequate decisions in conflict solving. Real-time simulation tests showed that, in almost all cases, an RWC maneuver is successfully performed, giving the RP sufficient time to assess the conflict, coordinate with the controller, if needed, and execute the maneuver. The fundamental role of the proposed RWC function has been especially evident in uncontrolled airspace classes where the controller does not provide any separation provision. Moreover, its effectiveness has also been tested in encounters with aircraft flying under visual flight rules in controlled airspace, where the controller is not informed or has less information regarding these aircraft. The results from validation tests imply two key potential safety benefits, namely: the mitigation of performing a collision avoidance maneuver and the prevention of potential conflict while not disrupting the traffic flow with possible further consequences of generating other potentially hazardous situations.
A Review of Non-Destructive Evaluation (NDE) Techniques for Residual Stress Profiling of Metallic Components in Aircraft Engines
Authors: Shao Zhaoyu , Zhang Chengcheng , Li Yankai , Shen Hai , Zhang Dehan , Yu Xudong , Zhang Ying
Published: September 2022

Residual stresses are one of the main factors determining the failure of aircraft engine materials. It is not possible to reliably and accurately predict the remaining service life of aircraft engine components without properly accounting for the presence of residual stresses. The absolute level and spatial distribution of the residual stress is uncertain in aircraft engines because the residual stress profile is highly susceptible to variations in the manufacturing process. In addition, residual stresses keep evolving under complex thermal-mechanical loadings. Non-destructive techniques are desired by the aerospace industries for the regular monitoring of subsurface residual stress profile in aircraft engine components. The insufficient penetrating capability of the only currently available non-destructive residual stress assessment technique X-ray diffraction has prompted an active search for alternative non-destructive techniques. This paper provides an overview of the principle, practical applications, advantages, and limitations of four categories of nondestructive (diffraction, ultrasonic, and electromagnetic) techniques for residual stress profiling of metallic components in aircraft engines.
Genome-Wide Identification and Molecular Evolution of the Magnesium Transporter (MGT) Gene Family in Citrullus lanatus and Cucumis sativus
Authors: Heidari Parviz , Puresmaeli Fatemeh , Mora-Poblete Freddy
Published: September 2022

Magnesium transporters (MGTs) play a prominent role in the absorption, transportation, and storage of magnesium in plant cells. In the present study, MGT gene family members were identified and characterized into two species of Cucurbitaceae, including Cucumis sativus and Citrullus lanatus. Totals of 20 and 19 MGT genes were recognized in Citrullus lanatus and Cucumis sativus, respectively. According to their physicochemical properties, the members of each sub-class of MGTs in the species of Cucurbitaceae showed the close relationship. Proteins from NIPA class were identified as hydrophilic proteins with high stability. Based on phylogenetic analysis, MGT family members were classified into three groups, and NIPAs showed more diversity. Moreover, duplication events were not identified between the MGT genes in C. lanatus and C. sativus. According to pocket analysis, residues such as L, V, S, I, and A were frequently observed in the binding sites of MGT proteins in both studied species. The prediction of post-translation modifications revealed that MSR2 proteins have higher phosphorylation potentials than other sub-classes of MGT in both studied plants. The expression profile of MGTs showed that MGTs are more expressed in root tissues. In addition, MGTs showed differential expression in response to abiotic/biotic stresses as well as hormone application and NIPAs were more induced in response to stimuli in watermelon. The results of this study, as the primary work of MGT gene family, can be used in programs related to Cucurbitaceae breeding.