bluuebunny/crossref_metadata_2025 huggingface dataset:
Digitalisasi Keuangan dengan Pemanfaatan Aplikasi Pembukuan Secara Online untuk Meningkatkan Daya Saing UMKM Besek
Authors: Trianti Khoiriyah , Widyawati Chici Elvina , Anggraeni Delfia , Husniah Hudratil Yaumil
Published: March 2022

Saat ini era teknologi semakin berkembang. Perkembangan era teknologi berbasis IT dan Internet of Thinks menyebabkan pemanfaatan teknologi berbasis Android dapat diakses kapan pun dan dimanapun. Pemanfaatan aplikasi berbasis android digunakan oleh semua bidang, baik bidang pendidikan, pemasaran, dan keuangan. Pemanfaatan apliaksi pembukuan berbasis Android dapat digunakan sebagai pengelolaan pencatatan transaksi keuangan secara mudah dan aplikatif bagi pelaku usaha. Pelaku usaha di Desa Duwet Dusun Kedampul Kecamatan Tumpang Kabupaten Malang mempunyai potensi alam bambu yang melimpah serta sebagian penduduk Desa banyak yang mempunyai usaha kerajinan anyaman besek yang terbuat dari bambu. Kegiatan UMKM di desa tersebut banyak yang belum memanfaatkan aplikasi berbasis Android. Berdasarkan hal tersebut maka dipilihlah Dusun Kedampul Desa Duwet sebagai lokasi untuk melaksanakan Kandidat Sarjana Mengabdi (KSM). Pelaksanaan kegiatan Pengabdian kepada Masyarakat ini dilaksanakan pada bulan Agustus - September 2021 yaitu berupa kegiatan Pengenalan pengelolaan keuangan bagi pelaku usaha, pengenalan aplikasi pembukuan berbasis Android.  Beberapa manfaat praktis yang diharapkan dari pelaksanaan KSM, yaitu: (1) mereka mendapatkan informasi yang jelas dan utuh mengenai manajemen keuangan bagi pelaku usaha (2) mengenali aplikasi pembukuan berbasis android (3) peserta mampu melaksanakan aplikasi pembukuan berbasis android.
Pengembangan Sistem Pemasaran melalui Media Online bagi UMKM Batik Tulis di Masa Pandemi Covid-19
Authors: Hardaningtyas Ratna Tri , Mubarok Ahmad Rifqi
Published: March 2022

Usaha Mikro, Kecil dan Menengah (UMKM) telah menyebar di seluruh wilayah indonesia. Salah satu UMKM yang khas di Desa Argotirto yaitu batik tulis. Karena pandemi, penjualan dari batik ini sempat vakum selama beberapa bulan. Oleh karena itu pemberdayaan UMKM Batik Tulis sangat di butuhkan guna untuk mengembangkan usaha Batik Tulis di Desa Argotirto ini. Di era pandemi masyarakat harus bisa memanfaatkan UMKM yang ada, mengolahnya serta memasarkan dalam media offline atau online agar ekonomi masyarakat bisa bertambah khususnya di era pandemi seperti sekarang ini. Salah satu upaya yang bisa di lakukan adalah dengan memberdayakan UMKM dengan cara memberi inovasi motif batik tulis agar dapat lebih update motif sehingga konsumen mudah tertarik, serta membantu pemasaran di media massa karena jangkauan pasarnya lebih luas dan praktis di bandingkan brosur dan door to door. Diharapkan berbagai kegiatan yang di lakukan dapat menambah wawasan, ilmu serta membantu majunya UMKM Batik Tulis, sehingga dapat membantu ekonomi masyarakat.
EVALUASI KEBIJAKAN FULL DAY SCHOOL TERHADAP EKSISTENSI MADRASAH DINIYAH
Authors: Luthfi Rois
Published: March 2022

Abstrak

 

Full Day School merupakan kebijakan yang dikeluarkan oleh Mendikbud Muhadjir Efendy dengan adanya Permendikbud Nomor 23 Tahun 2017 tentang Hari Sekolah. Dengan keluarnya permendikbud ini maka sekolah yang asalnya enam hari menjadi lima hari dengan ketentuan delapan jam pelajaran setiap harinya. Yang asalnya kegiatan belajar mengajar dari pagi sampai siang, maka dengan adanya kebijakan ini kegiatan belajar mengajar menjadi pagi sampai sore hari.

Tidak sedikit masyarakat yang menanggapi negatif dari kebijakan full day school ini. Mereka menganggap bahwa full day school dapat mematikan kegiatan sekolah sore / sekolah keagamaan / madrasah diniyah. Selain itu, mereka juga menganggap bahwa kebijakan ini akan membuat para siswa kurang bersosial dengan masyarakat. Dan masih banyak permasalahan lainnya.

Dengan adanya tanggapan negatif masyarakat tersebut, maka kebijakan ini perlu adanya evaluasi. Yaitu dengan mempertanyakan kembali bagaimana sebenarnya proses pelaksanaan full day school ini?, apakah semua sarana-prasarana di sekolah-sekolah sudah memadai?, bagaimana dengan para siswa yang rumahnya jauh dari sekolah? Bagaimana dengan para siswa yang sore harinya harus mengaji di pondok pesantren atau madrasah diniyah?, dan lain-lain. Hasil akhir dari evaluasi ini adalah revisi kebijakan atau bahkan penghapusan kebijakan.

 

Kata Kunci : full day school, pro dan kontra, madrasah diniyah, evaluasi
GAWAI DAN IBU MUDA : STUDI POLA ASUH IBU MUDA PADA ANAK DI DUSUN KARANGANYAR
Authors: Muadi M
Published: March 2022

Media soaial merupakan sumber informasi yang bisa mengubah segala hal sisikehidupan manusia. Hal ini tidak terlepas dari perkembangan teknologi yang merambah kaum hawa khususnya ibu muda. Dikalangan ibu muda media sosial diangap unggul didalam kecepatan interaksi segala informasi bisa dengan mudah didapatkan. Tidak hanya itu, media sosial juga sebagai ruang khusus untuk para ibu muda berbagi pengalaman. Bahkan tidak sedikit yang kemudian menganggapnya sebagai label kekinian demi menjaga gengsi. Pandangan masyarakat melihat perempuan yang masih didominasi dalam segala hal oleh laki-laki. Buat perempuan media sosial menjadi sarana untuk membuktikan bahwa  perempuan bisa mengaktualisasi diri mereka dengan baik. Sehingga ketimpangan sosial terhadap laki-laki bisa teratasi, perempuan yang aktif dalam media sosial dan tidak adanya kontrol secara langsung yang diberikan oleh orang tua, terdapat upaya kontrol yang diberikan dari orang tua. Dalam membatasi perilaku pemain gawai yang tidak sesuai dengan nilai dan norma dimasyarakat.
MANAJEMEN MUTU SMK MA’ARIF NU 1 BENER PURWOREJO DALAM MENINGKATKAN MUTU PENDIDIKAN DAN KEPERCAYAAN MASYARAKAT
Authors: ., Eliyanto , Muzamil Agus
Published: March 2022

Penelitian ini didasari oleh pentingnya manajemen mutu sekolah. Sehubungandengan hal tersebut, penelitian ini bertujuan untuk mengetahui Manajemen Mutu SMKMaarif NU 1 Bener Purworejo dalam Meningkatkan Mutu Pendidikan dan KepercayaanMayarakat. Penelitian ini merupakan penelitian kualitatif. Pengumpulan datamenggunakan wawancara, observasi, dan dokumentasi, dan keabsahan datamenggunakan triangulasi, dan teknik analisis data meliputi pegumpulan data, reduksidata, penyajian data, dan penarikan kesimpulan. Penelitian ini menghasilkan empatkesimpulan: (1) Perencanaan SMK Maarif NU 1 Bener Purworejo dalam meningkatkanmutu pendidikan dan kepercayaan masyarakat yaitu: Pertama, Penetapan standar mutu,yang mengacu pada 8 Standar Nasional Pendidikan. Kedua, Pemetaan mutu, yangdidasarkan pada hasil Evaluasi Diri Sekolah dan SNP (Standar Nasional Pendidikan).Ketiga, Penyusunan rencana pemenuhan mutu. (2) Pelaksanaan SMK Maarif NU 1 BenerPurworejo dalam meningkatkan mutu pendidikan dan kepercayaan masyarakat dilakukanmelalui pemenuhan Standar Isi, Standar Proses, Standar Kompetensi Lulusan, StandarPendidik dan Tenaga Kependidikan, Standar Sarana dan Prasarana, Standar Pengelolaan,Standar Penilaian Pendidikan, Standar Pembiayaan. Selanjutnya, seluruh komponensekolah juga memiliki komitmen tinggi dalam pelaksanaan pemenuhan mutu tersebut. (3)Evaluasi SMK Maarif NU 1 Bener Purworejo dalam meningkatkan mutu pendidikan dankepercayaan masyarakat dilakukan melalui Evaluasi Diri Sekolah. Pada tahap ini, sekolahmenyusun instrumen evaluasi kemudian membentuk tim pelaksana evaluasi. (4) TindakLanjut SMK Maarif NU 1 Bener Purworejo dalam meningkatkan mutu pendidikan dankepercayaan masyarakat dilakukan sebagai suatu siklus yang berkelanjutan, yaitu melalui:Corrective Action, tindakan perbaikan ini dilakukan jika hasilnya tidak mencapai apa yangtelah ditargetkan; dan Standardization Action, tindakan perbaikan ini dilakukan jikahasilnya mencapai target yang telah diteta
IMPLEMENTASI KONSEP MADRASAH BERWAWASAN LINGKUNGAN (Studi Kasus di MAN Purworejo)
Authors: Chamidah Nur
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan Sekolah Adiwiyata di MAN Purworejo yang mencakup 4 komponen program Adiwiyata, yaitu Kebijakan berwawasan lingkungan, Pelaksanaan Kurikulum Berbasis Lingkungan, Kegiatan Lingkungan Berbasis Partisipatif dan Pengelolaan Sarana Pendukung Ramah Lingkungan. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif. Informa penelitian ini adalah Tim Adiwiyata Sekolah, Kepala Sekolah, Wakil Kepala Sekolah Bidang Sarana dan Prasarana, Humas Sekolah, Guru, Karyawan dan Siswa. Lokasi penelitian di MAN Purworejo Teknik pengumpulan data dengan triangulasi melalui wawancara, observasi, dan studi dokumentasi. Hasil penelitian menunjukkan bahwa: (1) pelaksanaan kebijakan berwawasan lingkungan sudah terlaksana dengan merubah visi misi yang mendukung pengelolaan lingkungan dan adanya alokasi dana untuk program Adiwiyata dalam upaya perlindungan dan pengelolaan lingkungan sekolah, kurikulum berwawasan lingkungan dilaksanakan dengan mengintegrasikan materi wawasan lingkungan ke dalam mata pelajaran, kegiatan lingkungan bersifat partisipasif dilaksanakan melalui berbagai aksi lingkungan baik yang diselenggarakan dari sekolah maupun instansi dan mengelola sarana ramah lingkungan dengan memanfaatkan Green House, ruang terbuka hijau dan halaman sekolah untuk pembelajaran. (2) Sekolah telah mengupayakan beberapa kegiatan yang melibatkan peserta didik dalam program Adiwiyata, antara lain melibatkan siswa dalam aksi lingkungan, dan workshop lingkungan hidup dan pelatihan daur ulang limbah. Kendala yang dihadapi adalah kurangnya kerjasama dan kurangnya kesadaran para siswa terhadap kepedulian madrasah.

Kata Kunci: Sekolah Adiwiyata, Peningkatan Mutu Sekolah.
IMPLEMENTASI MANAJEMEN STRATEGIK PADA LEMBAGA PENDIDIKAN MAJELIS TAKLIM DARUNNAJAH DESA BEJIRUYUNG KECAMATAN SEMPOR KABUPATEN KEBUMEN
Authors: Kheroni Akh.
Published: March 2022

Penelitian ini membahas tentang implementasi manajemen strategik pada Majelis Taklim Darunnajah Desa Bejiruyung Kecamatan Sempor Kabupaten Kebumen. ini dimaksudkan untuk menjawab permasalahan: (1) Bagaimana pada Lembaga Pendidikan Majelis Taklim Darunnajah Desa Bejiruyung Kecamatan Sempor Kabupaten Kebumen? (2) Bagaimana pelaksananan strategik pada Lembaga Pendidikan Majelis Taklim Darunnajah Desa Bejiruyung Kecamatan Sempor Kabupaten Kebumen? (3) Bagaimana evaluasi strategik pada Lembaga Pendidikan Majelis Taklim Darunnajah Desa Bejiruyung Kecamatan Sempor Kabupaten Kebumen?

Permasalahan tersebut dibahas melalui studi lapangan. Jenis penelitian ini adalah penelitian kualitatif. Datanya diperoleh dengan cara observasi, wawancara dan dokumentasi. Semua data yang diperoleh kemudian dianalisis dengan reduksi data, display data dan verifikasi atau penarikan kesimpulan.

Hasil penelitian menemukan bahwa: (1) Perencanaan strategik Majelis Taklim Darunnajah Kebumen mencakup beberapa kegiatan yang dilakukan yaitu pengembangan visi, misi, dan tujuan, identifikasi faktor internal dan eksternal melalui teknik analisis SWOT, perencanaan jangka pendek, menengah, dan panjang, serta menentukan strategi unggul dalam meningkatkan mutu pendidikan. Perencanaan strategik Majelis Taklim Darunnajah Desa Bejiruyung Sempor dilakukan secara kolektif oleh Ketua, pengurus, tokoh agama dan tokoh masyarakat serta pejabat desa; (2) Pelaksanaan manajemen strategik Majelis Taklim Darunnajah mencakup pada kegiatan yang dilakukan yaitu menentukan kebijakan organisasi, memotivasi pengurus dan jamaah, mengalokasikan sumber daya manusia, serta mengembangkan budaya organisasi. Hasil pelaksanaan manajemen strategik yang dihasilkan di Majelis Taklim Darunnajah Desa Bejiruyung Sempor yaitu meningkatnya kinerja sumber daya manusia, proses pelaksanaan program yang efektif, dan daya tarik masyarakat tinggi; (3) Evaluasi manajemen Majelis Taklim Darunnajah Desa Bejiruyung Kecamatan Sempor Kabupaten Kebumen yaitu memonitor seluruh hasil kegiatan dari perencanaan dan pelaksanaan manajemen strategik, dan mengambil langkah perbaikan.
Analisis Hukum Kebijakan Penetapan Kawasan Rencana Detil Tata Ruang Terkait Izin Pembangunan di Kawasan Teluk Kendari
Authors: Rampoallo Jonova , Jufri Muhammad , Sensu La
Published: March 2022

Penelitian ini bertujuan menganalisis penyelenggaraan pelayanan publik berbasis Hak Asasi Manusia di lingkungan Kantor Wilayah Kementerian Hukum dan HAM apakah penyelenggaraannya sudah sesuai dengan prinsip good governance sehingga digunakan sebagai standar dalam pelayanan prima. penelitian ini adalah penelitian hukum yang menggunakan pendekatan perundang-undangan dan konseptual, penelitian ini menjawab masalah mengenai faktor yang dapat menghambat dalam pelaksanaan pelayanan prima dengan merujuk pada Peraturan Menteri Hukum dan HAM Nomor 27 Tahun 2018.
Indicadores de sustentabilidad turística: una aproximación metodológica para su selección en el destino turístico Galápagos
Authors:   Escuela Superior Politécnica de Chimborazo, Saeteros Hernandez Angelica Maria , Moreno Barriga Fabián Marcelo ,   Escuela Superior Politécnica de Chimborazo, Flores Paltán Santiago Ricardo ,   Escuela Superior Politécnica de Chimborazo
Published: March 2022

Debido al importante auge económico de las actividades turísticas y el impacto que esta genera se hace necesario definir acciones que permitan gestionar eficientemente los destinos. Este estudio tiene como objetivo definir un sistema de indicadores para el destino turístico Galápagos, empleando una metodología que combina el análisis cualitativo y cuantitativo partiendo de la conceptualización del turismo sustentable para el destino. El análisis inicial permitió identificar las dimensiones de la sustentabilidad y los indicadores con mayor incidencia, los cuales fueron seleccionados bajo la técnica de participación informada de expertos, deduciéndose a 80 indicadores a través del calculo de la mediana individual de las puntuaciones obtenidas en cinco criterios que finalmente se distribuyeron en 25 ambientales, 29 económicos, 10 socioculturales, 10 políticos y 6 tecnológicos, una vez seleccionados se verificó su robustez a través de la técnica de Estaninos, concluyendo que el conjunto de indicadores seleccionados presenta una elevada consistencia interna; esto es, que miden el concepto por el cual fueron elegidos y deja sentadas la base de un conjunto inicial de indicadores para monitorear la actividad turística a fin de garantizar la sostenibilidad del destino turístico Galápagos.
The Value of a Hole in Coal: Assessment of Seasonal Thermal Energy Storage and Recovery in Flooded Coal Mines
Authors: Perez Silva Jesus , McDermott Christopher , Fraser-Harris Andrew
Published: March 2022

Seasonal storage and extraction of heat in legacy coal mines could help decarbonize the space heating sector of many localities. The modelled evolution of a conceptual mine-water thermal scheme is analysed in this study, involving cyclical storage of heat in an enclosed underground coal mine. Conductive heat transport simulations are performed in a 3D model of a flooded room-and-pillar panel, based on typical mine layouts, to quantify the maximum thermal recovery from the host rock in different scenarios. We show that, by optimizing the seasonal management, from 25% to 45% of the energy transferred to the subsurface could be potentially recovered at the end of the first operational year. The modelled heat retrieval, achieved by subsurface cold-water circulation, does not consider the potentially enhancing effect of local advection around mine voids and applies to cases of relatively low dispersal of heat by the regional groundwater flow. The cumulative heat recovered from the modelled host rock could equal the thermal energy provided by the “mined” coal in less than 70 years. A comparison of the value of the original coal “mined,” at today’s prices, to a representative value for the heat recycled in the space created by its extraction, suggests that within less than 3 decades of thermal cycling similar monetary values are reached for the specific conditions modelled.
Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Authors: Jia Jianhang , Jiang Jin
Published: March 2022

The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling. Recent studies have demonstrated that Smo is subjected to ubiquitination mediated by multiple E3 ubiquitin ligases, leading to Smo endocytosis and subsequent degradation through the proteasome- and lysosome-mediated pathways in Drosophila. Ubiquitination of Smo also promotes its ciliary exit in mammalian cells. Hh inhibits Smo ubiquitination by blocking E3 ligase recruitment and promoting Smo deubiquitination through the ubiquitin-specific protease 8 (USP8) in Drosophila. Inhibition of Smo ubiquitination by Hh promotes Smo cell surface accumulation in Drosophila and ciliary accumulation in mammalian cells. Interestingly, Hh also induces sumoylation of Smo in both Drosophila and mammalian cells, which promotes Smo cell surface/ciliary accumulation. This review focuses on how ubiquitination and sumoylation regulate Smo intracellular trafficking and abundance and how these processes are regulated by Hh.
Association Between Socioeconomic Status and Prevalence of Cardio-Metabolic Risk Factors: A Cross-Sectional Study on Residents in North China
Authors: Hao Zhihua , Wang Mian , Zhu Qiuxiao , Li Jie , Liu Zibo , Yuan Lingling , Zhang Yue , Zhang Lihui
Published: March 2022

Studies have found associations between cardio-metabolic disorders and socioeconomic status (SES) in developed areas. However, little epidemiological data are available on residents of less developed areas in North China. A cross-sectional study that consisted of 2,650 adults randomly selected from local residents was conducted on a developing province, Hebei. SES was assessed in terms of education, personal income per year, and occupation. The association between SES and metabolic syndrome (MetS) was determined by multivariate logistic regression. The weighted prevalence of MetS was 26.8% among residents of Hebei province. The lower prevalence of MetS and abdominal obesity was associated with increase in SES groups. After adjustments regarding age, sex, body mass index, living area, smoking, salt intake, and family history of diabetes, odds ratio (OR) for elevated blood pressure (BP) of individuals with higher SES level was 0.71 [95% confidence interval (CI): 0.542–0.921] compared with those with lower SES level. Cardio-metabolic risk factors were commonly identified among residents of Hebei province in north China and were associated with SES conditions. This study indicated that from a public health perspective, more attention should be paid to screening of cardio-metabolic disorders in less developed areas.
Case Report: Two Case Reports of Acute Myopericarditis After mRNA COVID-19 Vaccine
Authors: Sciaccaluga Carlotta , D'Ascenzi Flavio , Cameli Matteo , Gallotta Maddalena , Menci Daniele , Antonelli Giovanni , Banchi Benedetta , Mochi Veronica , Valente Serafina , Focardi Marta
Published: March 2022

Background

Cases of myocarditis and myopericarditis after mRNA COVID-19 vaccines have been reported, especially after the second dose and in young males. Their course is generally benign, with symptoms onset after 24–72 h from the dose.

Case Summary

We report two cases of myopericarditis after the second dose of the mRNA-1273 COVID-19 vaccine in two young males. Both the patients were administered the mRNA-1273 COVID-19 vaccine from the same batch on the same day and experienced fever on the same day of the vaccine, and symptoms consisted of myopericarditis 3 days after the dose.

Discussion

Myopericarditis is usually considered an uncommon adverse reaction after various vaccinations, reported also after the mRNA COVID-19 vaccine. Several explanations have been proposed, including an abnormal activation of the immune system leading to a pro-inflammatory cascade responsible for myocarditis development. Both patients experienced the same temporal onset as well as the same symptoms, it is also useful to underscore that both vaccines belonged to the same batch of vaccines. However, despite these cases, vaccination against COVID-19 far outweighs the risk linked to COVID-19 infection and remains the best option to overcome this disease.
Accuracy of Sterile and Non-Sterile CAD/CAM Insertion Guides for Orthodontic Mini-Implants
Authors: Ludwig Björn , Krause Luisa , Venugopal Adith
Published: March 2022

Aim

The aim of this study was to measure the transfer accuracy of computer-aided design/computer-aided manufacturing (CAD/CAM) insertion guides using mini-implants. The target value is the virtual planned position (100%). It is also clinically mandatory to use sterilised surgical guides (autoclaved at 137°C). The results obtained using sterilised and non-sterilised insertion guides were compared. In addition, the actual position of the mini-implants, as implemented, was compared with the digitally planned positions.

Materials and Methods

Following CAD/CAM planning and production of 60 insertion guides made from synthetic resins that had been previously tested for suitability, 120 mini-implants were inserted in pairs and in blocks of the bone of the substitute material. Half of the insertion guides were sterilised, while the other half were non-sterilised. Compared with the position of the mini-implants in the digital plans, deviations in the apical and coronal distances between the mini-implants and insertion depth, as well as the included angle of the mini-implants to one another and to the surface of the bone substitute material, were determined.

Results

In post-sterilisation, the dimensional and material changes were observed. When compared, the deviations to the virtual planned position were achieved when the performed insertion using sterilised insertion guides were lower than those achieved when using non-sterilised insertion guides. The heat treatment during the sterilisation process improved the accuracy of the insertion guides. When comparing sterile insertion guides to the digital planned position (100%), the mean coronal deviation was 0.057 mm (0.81%), the apical deviation was 0.428 mm (6.11%), and insertion depth mean deviation at the right side was 0.15 mm (2.15%), while that on the left was 0.073 mm (1.04%).

Conclusion

The CAD/CAM TAD insertion guide could not achieve 100% accuracy in translating the digitally planned position into the real anatomic location. Deviations to the ideal position between 0.81 and 6.11% were observed. Clinically, for appliances that fit post-mini-implant insertion, the coronal distance of the mid-mini-implant head is the most important. At this point, the mean deviation to the planned positions is 0.81%, which is clinically acceptable and most likely reproducible by using CAD/CAM insertion guides.
Experimental Study on the Influence of Microbial Content on Engineering Characteristics of Improved Expansive Soil
Authors: Ouyang Qianwen , Xiao Hongbin , Li Zhenyu , Jiang Weichang , Su Huanyu , Tian Xuwen , Ouyang Miao
Published: March 2022

In order to study the influence of microbial content on the engineering properties of expansive soil im-proved by microbially induced calcium carbonate (MICP) method, and to clarify its influence law and mechanism of action, and to provide some theoretical reference for the application of MICP method to expansive soil treatment. Microbial reproduction and their mineralization in expansive soils have been studied. The problems such as moisture content controlling and low calcium content in the process of treating expansive soil with MICP method have been solved by means of adding calcium salt and using optimum moisture content as the control standard of the total amount of bacterial solution and cementation solution. The tests such as compaction, swelling rates and triaxial shear are carried out. The hydrophilicity, compaction, expansibility and strength characteristics of improved expansive soil under different microbial content are analyzed. The results demonstrate that with the increasing of microbial content, the dry density and shear strength of the improved soil are first increased significantly and then tend to be stable gradually. At the same time, the hydrophilicity and expansibility of improved soil are all decreased significantly. The microstructures of improved expansive soil are imaged by scanning electron microscope. Analytic results show that soil particles have been cemented and the pores in the soil have been filled due to microbially induced calcite precipitation. As a result, microstructure characteristics of the soil have been improved. From the microscopic point of view, the improvement mechanism of MICP method on expansive soil has been revealed. The conclusions above laid a theoretical foundation for in-tensive study on the improvement of expansive soil by MICP method. It also provides a new idea for perfecting and expanding the engineering application of expansive soil improvement technology.
Experimental Investigation of the Adsorption and Desorption Kinetics on an Open-Structured Asymmetric Plate Heat Exchanger; Matching Between Small-Scale and Full-Scale Results
Authors: Mikhaeil Makram , Gaderer Matthias , Dawoud Belal
Published: March 2022

This paper introduces the results of an experimental study on the adsorption and desorption kinetics of a commercially available, open-structured asymmetric plate heat exchanger adapted to act as an adsorber/desorber for the application in adsorption heat transformation processes. In addition, a volumetric large temperature jump (V-LTJ) kinetic setup was applied to measure the adsorption and desorption kinetics of a small-scale adsorbent sample prepared dedicatedly to be representative for the adsorbent domain inside the investigated adsorber plate heat exchanger (APHE). All kinetic results of the small-scale adsorbent sample and the APHE were fitted into exponential forms with a single characteristic time constant (τ) with a coefficient of determination (R2) better than 0.9531. A very good matching between the small-scale and full-scale adsorption kinetic measurements was obtained, with an average relative deviation of 12.3% in the obtained τ-values. In addition, the kinetic data of the small-scale adsorbent sample were utilized for estimating the expected specific instantaneous and moving average powers of the evaporator/condenser heat exchanger. The average relative deviation (ARD) between the moving average specific evaporator powers obtained from the small-scale and the full-scale measurements amounts between 5.4 and 15.1%.
Recent Developments Studies on Wood Protection Research in Academia: A Review
Authors: Khademibami Laya , Bobadilha Gabrielly S.
Published: March 2022

The wood preservation industry has taken large leaps to develop and produce chemicals that protect wood from microorganisms and weathering degradation with no or low environmental impact. These improvements occurred after concerns of federal and public agencies about the release of toxic components into atmosphere, soil, and water. These days, reduction in use of non-renewable resources is a crucial concern. Wood and wood-based products are generally low in CO2emissions and can be gained from sustainable forest resources. Therefore, they can play a significant role as renewable resources. In comparison to other building materials, wood has numerous advantages, such as suitable thermal insulation, high strength to weight ratio, easy machinability, and attractive esthetics. Wood as a valuable building and industrial material requires to be protected due to its biodegradable properties especially when it is submitted to harsh conditions. Wood durability can be improved through wood protection which include wood preservatives and modification systems. Wood protection should be safe to use, efficient, cost-effective, permanent, and should not corrode metal or degrade wood components. Numerous reviews of wood protection can be found in the scientific literatures, but until now a review of a combination of wood preservation and wood modification has not been studied. It should be considered that the latest research projects in wood protection in academia not always reflect the most current developments in the industry due to exclusive rights. The findings reported in academia contribute to the safe use of preservatives, advancement of wood modification techniques, as well as recycle and disposal of treated material. Therefore, in this study, the most current research and advancements promoted in the wood protection in academia are discussed which including an overall summary of the recent developments on wood preservatives, different types of preservatives, natural preservative compounds, and modification technologies in academia.
A Novel Ferroptosis-Related lncRNAs Signature Predicts Clinical Prognosis and Is Associated With Immune Landscape in Pancreatic Cancer
Authors: Ping Haiqin , Jia Xingqing , Ke Hengning
Published: March 2022

Pancreatic cancer is one of the most lethal malignancies and currently therapies are severely lacking. In this study, we aimed to establish a novel ferroptosis-related lncRNAs signature to predict the prognosis of patients with pancreatic cancer and evaluate the predictive abilities of candidate lncRNAs. According to The Cancer Genome Atlas (TCGA) database, a total of 182 patients with pancreatic cancer were included in our study. Ferroptosis-related lncRNAs were screened by Pearson correlation analysis with 60 reported ferroptosis-related genes. Through univariate, least absolute shrinkage and selection operator (LASSO) regression and multivariate regression analyses, a novel signature based on five ferroptosis-related lncRNAs(ZNF236-DT, CASC8, PAN3-AS1, SH3PXD2A-AS1, LINP1) was constructed. Risk-related differentially expressed genes (DEGs) were subjected to enrichment analyses for Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The results revealed that immune cell infiltration, immune-related functions and checkpoints were factors to affect prognoisis of pancreatic cancer. In summary, we identified the prognostic ferroptosis-related lncRNAs(ZNF236-DT, CASC8, PAN3-AS1, SH3PXD2A-AS1, LINP1) in pancreatic cancer and these lncRNAs may serve as therapeutic targets for pancreatic cancer.
A Necroptosis-Related lncRNA-Based Signature to Predict Prognosis and Probe Molecular Characteristics of Stomach Adenocarcinoma
Authors: Luo Lianghua , Li Leyan , Liu Li , Feng Zongfeng , Zeng Qingwen , Shu Xufeng , Cao Yi , Li Zhengrong
Published: March 2022

Background: As a caspase-independent type of cell death, necroptosis plays a significant role in the initiation, and progression of gastric cancer (GC). Numerous studies have confirmed that long non-coding RNAs (lncRNAs) are closely related to the prognosis of patients with GC. However, the relationship between necroptosis and lncRNAs in GC remains unclear.

Methods: The molecular profiling data (RNA-sequencing and somatic mutation data) and clinical information of patients with stomach adenocarcinoma (STAD) were retrieved from The Cancer Genome Atlas (TCGA) database. Pearson correlation analysis was conducted to identify the necroptosis-related lncRNAs (NRLs). Subsequently, univariate Cox regression and LASSO-Cox regression were conducted to establish a 12-NRLs signature in the training set and validate it in the testing set. Finally, the prognostic power of the 12-NRLs signature was appraised via survival analysis, nomogram, Cox regression, clinicopathological characteristics correlation analysis, and the receiver operating characteristic (ROC) curve. Furthermore, correlations between the signature risk score (RS) and immune cell infiltration, immune checkpoint molecules, somatic gene mutations, and anticancer drug sensitivity were analyzed.

Results: In the present study, a 12-NRLs signature comprising REPIN1-AS1, UBL7-AS1, LINC00460, LINC02773, CHROMR, LINC01094, FLNB-AS1, ITFG1-AS1, LASTR, PINK1-AS, LINC01638, and PVT1 was developed to improve the prognosis prediction of STAD patients. Unsupervised methods, including principal component analysis and t-distributed stochastic neighbor embedding, confirmed the capability of the present signature to separate samples with RS. Kaplan-Meier and ROC curves revealed that the signature had an acceptable predictive potency in the TCGA training and testing sets. Cox regression and stratified survival analysis indicated that the 12-NRLs signature were risk factors independent of various clinical parameters. Additionally, immune cell infiltration, immune checkpoint molecules, somatic gene mutations, and half-inhibitory concentration differed significantly among different risk subtypes, which implied that the signature could assess the clinical efficacy of chemotherapy and immunotherapy.

Conclusion: This 12-NRLs risk signature may help assess the prognosis and molecular features of patients with STAD and improve treatment modalities, thus can be further applied clinically.
Myeloid Responses to Extracellular Vesicles in Health and Disease
Authors: Makhijani Priya , McGaha Tracy L.
Published: March 2022

Extracellular vesicles are mediators of cell-cell communication playing a key role in both steady-state and disease conditions. Extracellular vesicles carry diverse donor-derived cargos, including DNA, RNA, proteins, and lipids that induce a complex network of signals in recipient cells. Due to their ability to capture particulate matter and/or capacity to polarize and orchestrate tissue responses, myeloid immune cells (e.g., dendritic cells, macrophages, etc.) rapidly respond to extracellular vesicles, driving local and systemic effects. In cancer, myeloid-extracellular vesicle communication contributes to chronic inflammation, self-tolerance, and therapeutic resistance while in autoimmune disease, extracellular vesicles support inflammation and tissue destruction. Here, we review cellular mechanisms by which extracellular vesicles modulate myeloid immunity in cancer and autoimmune disease, highlighting some contradictory results and outstanding questions. We will also summarize how understanding of extracellular vesicle biology is being utilized for novel therapeutic and diagnostic applications.
TH Cells and Cytokines in Encephalitogenic Disorders
Authors: Krishnarajah Sinduya , Becher Burkhard
Published: March 2022

The invasion of immune cells into the central nervous system (CNS) is a hallmark of the process we call neuroinflammation. Diseases such as encephalitides or multiple sclerosis (MS) are characterised by the dramatic influx of T lymphocytes and monocytes. The communication between inflammatory infiltrates and CNS resident cells is primarily mediated through cytokines. Over the years, numerous cytokine networks have been assessed to better understand the development of immunopathology in neuroinflammation. In MS for instance, many studies have shown that CD4+T cells infiltrate the CNS and subsequently lead to immunopathology. Inflammatory CD4+T cells, such as TH1, TH17, GM-CSF-producing helper T cells are big players in chronic neuroinflammation. Conversely, encephalitogenic or meningeal regulatory T cells (TREGs) and TH2 cells have been shown to drive a decrease in inflammatory functions in microglial cells and thus promote a neuroprotective microenvironment. Recent studies report overlapping as well as differential roles of these cells in tissue inflammation. Taken together, this suggests a more complex relationship between effector T cell subsets in neuroinflammation than has hitherto been established. In this overview, we review the interplay between helper T cell subsets infiltrating the CNS and how they actively contribute to neuroinflammation and degeneration. Importantly, in this context, we will especially focus on the current knowledge regarding the contribution of various helper cell subsets to neuroinflammation by referring to their helper T cell profile in the context of their target cell.
Different Multivariable Risk Factors for Rapid Progressive Interstitial Lung Disease in Anti-MDA5 Positive Dermatomyositis and Anti-Synthetase Syndrome
Authors: Zuo Yu , Ye Lifang , Chen Fang , Shen Yawen , Lu Xin , Wang Guochun , Shu Xiaoming
Published: March 2022

Background

Interstitial lung disease (ILD) is frequently observed in anti-melanoma differentiation-associated protein 5 (MDA5) antibody positive dermatomyositis (DM) and anti-synthetase syndrome (ASS), where they often develop a rapidly progressive ILD (RP-ILD) leading to poor prognosis.

Objective

The aim of this study was to construct multivariable prediction risk factors for rapid progressive ILD (RP-ILD) in anti-MDA5 positive DM (MDA5+DM) and ASS.

Methods

333 idiopathic inflammatory myopathy (IIM) associated ILD patients were studied retrospectively. Risk factors for RP-ILD in MDA5+DM and ASS patients were identified by univariate and multivariable logistic regression analysis. The mortality was assessed using Kaplan-Meier analysis.

Results

RP-ILD was more prevalent in MDA5+DM patients than ASS patients. MDA5+DM patients with RP-ILD had significantly lower survival rates than those in ASS patients. The independent risk factors for RP-ILD in MDA5+DM patients were fever (OR 3.67, 95% CI:1.79-7.52), lymphopenia (OR 2.14, 95% CI:1.01-4.53), especially decreased levels of CD3+T cells (OR 2.56, 95% CI:1.17-5.61), decreased levels of CD3+CD4+ T cells (OR 2.80, 95% CI:1.37-5.73), CD3+CD8+T cells (OR 2.18, 95% CI:1.05-4.50), elevated CD5-CD19+ B cells (OR 3.17, 95% CI:1.41-7.13), elevated ALT (OR 2.36, 95% CI:1.15-4.81), high lactate dehydrogenase (LDH) (OR 3.08, 95% CI:1.52-6.27), hyper-ferritin (OR 4.97, 95% CI:1.97-12.50), elevated CEA (OR 2.28, 95% CI:1.13-4.59), and elevated CA153 (OR 3.31, 95% CI:1.50-7.27). While the independent risk factors for RP-ILD in ASS patients were elevated CEA (OR 5.25, 95% CI: 1.73-15.93), CA125 (OR 2.79, 95% CI: 1.10-7.11) and NSE (OR 4.86, 95% CI: 1.44-16.37). Importantly, serum ferritin>2200ng/ml predicted patient’s death within half a year in MDA5+DM patients with RP-ILD, but not in ASS patients.

Conclusions

There were significant different mortality and multivariable risk factors for RP-ILD in MDA5+DM patients and ASS patients. Potential clinical benefits of using these different risk factors deserve assessment of severity and prognosis in IIM patients.
Potential Plasticity of Artificial Feed Preference in Juvenile Pharaoh Cuttlefish (Sepia pharaonis) Through Progressive Training Programs
Authors: Ma Chia-Huan , Lin Chih-Hung , Chang Yung-Cheng , Lee Hung-Tai , Liou Chyng-Hwa , Hsu Te-Hua
Published: March 2022

The cuttlefish is a commercially important marine species across the world; however, due to the lack of appropriate artificial feed, there is limited future aquaculture development of the cuttlefish. We proposed a novel process comprising (1) feed preference tests and (2) progressive training programs. Through this process, artificial diets can become more suitable for pharaoh cuttlefish (Sepia pharaonis). Feed preference tests (based on vision, touch, and smell) revealed that pharaoh cuttlefish preferred rod-shaped feed to flat rod-shaped or ball-shaped feed, moist feed over dry feed (DF), and DF with agar coating to DF without agar coating. Without olfactory training, some cuttlefish refused to eat artificial feed and eventually died. Through progressive training programs (3- and 6-week programs), a survival rate of >80% was achieved. Although the artificial diets examined in this study resulted in a lower conversion ratio for S. pharaonis than for fresh shrimp, available artificial feed can potentially be adopted for cuttlefish aquaculture through the use of our progressive training program.
Effect of Ti/Al Ratio on the Elemental Partitioning in the Face-Centered Cubic-Based γ-γ′ Dual-Phase High Entropy Alloy Studied by Atom Probe Tomography
Authors: Han Bin , He Feng , Xia Linfei , Wang Zhijun , Kai Ji Jung
Published: March 2022

The effect of Ti/Al ratio on the elemental partitioning in the Ni2CoFeCrTixAly high entropy alloy was studied by atom probe tomography (APT). The APT results indicate that the γ′ nanoparticles have a composition of (NiCoFeCr)3TiAl which is independent of Ti/Al ratio. The effect of Ti/Al ratio on the partitioning behaviors of Fe and Cr are significantly different from that of Co. The decreasing of Ti/Al ratio significantly enhanced the incorporation of Fe and Cr into the γ′ nanoparticles. However, the concentration of Co in the γ′ nanoparticles declined with the decrease of Ti/Al ratio.
Increased CDCA2 Level Was Related to Poor Prognosis in Hepatocellular Carcinoma and Associated With Up-Regulation of Immune Checkpoints
Authors: Tang Mengying , Liao Mingchu , Ai Xiaohong , He Guicheng
Published: March 2022

Background

Cell division cycle-associated protein 2 (CDCA2) is a member of cell cycle-related proteins. CDCA2 plays a role in the regulation of protein phosphatase 1(PP1) γ-dependent DNA damage response (DDR) and H3 phosphorylation. CDCA2 promotes the tumorigenesis and development of several types of cancers by promoting the proliferation of tumor cells. However, the relationship between CDCA2 expression and the clinicopathological characteristics of hepatocellular carcinoma (HCC) is unknown.

Methods

Gene expression information and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. The expression of CDCA2 and its correlation to clinical characteristics in HCC were analyzed. The expression level of CDCA2 was validated in HCC cell lines. The relationship between CDCA2 expression and the survival of patients with HCC was analyzed by using Kaplan–Meier method. The prognostic value of CDCA2 in HCC was estimated by Cox regression analysis. The expression difference of CDCA2 between HCC and normal tissues and its correlation to survival were verified in independent datasets. Gene set enrichment analysis (GSEA) was used to screen the CDCA2-related signaling pathways.

Results

Cell division cycle-associated protein 2 expression was upregulated in HCC tissues (p < 0.001) and increased CDCA2 was correlated to increased T stage, pathologic stage, histologic grade, and alpha-fetoprotein (AFP) level (p < 0.001). In addition, CDCA2 was overexpressed in HCC cell lines HepG2 and LM3. High CDCA2 expression level was associated with poor overall survival [hazard ratio (HR) = 1.69; 95% CI, 1.20–1.40, p = 0.003], disease specific survival (HR = 1.73; 95% CI, 1.11–2.71, p = 0.016), and progress free interval (HR = 1.74; 95% CI, 1.30–2.34, p < 0.001). Overexpression of CDCA2 and its correlation to poor survival in HCC were verified in Gene Expression Omnibus (GEO) datasets and Kaplan–Meier plotter database. Increased CDCA2 expression was associated with upregulation of PD-L1 (Spearman's coefficient = 0.207, p < 0.001), PD-L2 (Spearman coefficient's = 0.118, p < 0.05), and CTLA4 (Spearman's coefficient = 0.355, p < 0.001). GSEA showed that homologous recombination pathway, insulin signaling pathway, mitogen-activated protein kinase (MAPK) pathway, mismatch repair pathway, mechanistic target of rapamycin (mTOR) pathway, Notch pathway, T cell receptor pathway, toll like receptor pathway, and WNT pathway were enriched in CDCA2 high expression phenotype.

Conclusion

Cell division cycle-associated protein 2 may serve as an independent biomarker for poor prognosis in HCC and increased CDCA2 expression was associated with upregulation of immune checkpoints.
Analysis of Ocular Surface Characteristics and Incidence of Dry Eye Disease in Systemic Lupus Erythematosus Patients Without Secondary Sjögren's Syndrome
Authors: Gu Zhengyu , Lu Qinyi , Zhang Ao , Shuai Zong Wen , Liao Rongfeng
Published: March 2022

Objective

To investigate the differences in ocular surface characteristics, tear film quality, and the incidence of dry eye disease (DED) between Systemic Lupus Erythematosus (SLE) patients and healthy populations.

Methods

This age and gender-matched cross-sectional study included 96 SLE patients without secondary Sjögren's syndrome (SS) and 72 healthy subjects. The Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), non-invasive tear film breakup time (NIKBUT), meibography, and tear film lipid layer grade were assessed. A receiver operative characteristic (ROC) curve was constructed to evaluate the predictive value of risk factors.

Results

Compared with the control subjects, a significantly greater proportion of SLE patients met the TFOS DEWS II DED diagnostic criteria (34.3 vs. 18.1%, P = 0.019). SLE patients without SS had higher OSDI scores [10.0 (4.5,18.0) vs. 5.0 (2.5,11.9), P < 0.001], and shorter NIKBUT [9.6 (6.6,15.0) vs. 12.3 (8.4, 15.8), P = 0.035]. Furthermore, TMH, Tear film lipid layer grade, and Meibomian gland (MG) dropout in SLE patients were worse than those in control subjects (all P < 0.05). For ROC analysis, the area under curve (AUC), sensitivity and specificity of prediction were 0.915, 75.8 and 92.1% for the combination of SLE disease activity index (SLEDAI), age and NIKBUT.

Conclusions

SLE patients without SS exhibited a higher risk for DED than healthy subjects, and the poorer Meibomian gland function in SLE patients may potentially contribute to the development of DED. The combined parameters of SLEDAI, age and NIKBUT showed a high efficiency for the diagnosis of DED in SLE patients, with practical clinical applications.
Posterior Reversible Encephalopathy Syndrome After Self-Medication With an Oral Decongestant: A Case Report
Authors: Zerbib Yoann , Gibert Louis , Bennis Youssef , Masmoudi Kamel , Maizel Julien , Brault Clément
Published: March 2022

Introduction

Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder caused by the dysregulation of cerebral perfusion.

Case Presentation

We report on a 18-year-old female patient with a history of end-stage renal disease and thrice weekly hemodialysis. She was admitted to the emergency department with mental confusion, blurred vision, headaches, and vomiting, following self-medication with an oral decongestant containing pseudoephedrine. We observed hypointense lesions with T1-weighted MRI and hyperintense areas with T2-weighted and fluid-attenuated inversion recovery MRI sequences. The lack of diffusion restriction was consistent with a diagnosis of PRES. A concomitantEnterobacter cloacaehemodialysis catheter-bloodstream infection was also diagnosed. We hypothesize that both sepsis and inappropriate self-medication with oral pseudoephedrine contributed to hypertension, endothelial dysfunction, and vasogenic edema. The patient received intensive care and made a full recovery.

Discussion

PRES is a life-threatening condition that requires intensive care. Identification of the etiology is the keystone of medical care. Inappropriate self-medication with an oral decongestant might trigger PRES - highlighting the importance of patient education.