bluuebunny/crossref_metadata_2025 huggingface dataset:
Kadı Ahmed Gaffârî’nin Târîh-i Cihân-ârâ Adlı Eserinde Türkiye Selçuklu Devleti
Authors: Çiftçi Ömer , Tansü Yunus Emre
Published: December 2024

Safevî şahı I. Şah Tahmasb’ın (ö. 984/1576) dönemi tarihçilerinden olan Ahmed b. Muhammed-i Gaffârî-i Kazvînî (ö. 975/1567), kendinden önceki ve sonraki dönemler ile ilgili verdiği bilgiler açısından oldukça önemli bir yazardır. Müellifin bilinen iki eseri günümüze ulaşmıştır. Bunlardan birisi çalışmamızın da konusu olan ve “Dünyayı süsleyen tarih” mânasına gelen Târîh-i Cihân-ârâ veya Nüsah-i Cihân-ârâ adlı eserdir. Eserin dördüncü bâbının altıncı faslı Selçuklular’a ayrılmış ve Selçuklular tarihi dört bölüm halinde anlatılmıştır. Birinci bölümde Selçukluların ortaya çıkışından başlayıp günümüzde Büyük Selçuklular ve Irak Selçukluları olarak isimlendirilen dönem hakkında, ikinci bölümde Rûm (Anadolu) Selçukluları hakkında, üçüncü bölümde müellifin Şam Selçukluları olarak isimlendirdiği Suriye Selçukluları ve dördüncü bölümde ise Kirman Selçukluları hakkında bilgi verilmektedir. Çalışmamızın konusunu eserin ikinci bölümünde anlatılan Rûm (Anadolu) Selçukluları oluşturmaktadır. Müellif, bu bölümde çok fazla detaya inmeyerek sadece zikrettiği Sultanın dönemindeki önemli olayları nakletmiştir. Çalışmamızda eserin Hasan-ı Nerâkî tarafından yapılan neşri esas alınarak, Selçuklular tarihi çalışmalarına katkıda bulunulması açısından tercüme edilmiş ve notlandırılmıştır.
Factors associated with death in patients with atrial fibrillation
Authors: Duvanovа S. P. , Khoroshavtseva L. V. , Gorbunova E. V. , Mamchur S. E. , Barbarash O. L.
Published: December 2024

The aim of the study was to analyze the factors influencing the mortality prognosis for atrial fibrillation (AF) among the adult population of the Kuzbass region.

Methods. 576 patients with AF were included in the study. During a three-year follow-up death was recorded in 54 (9.4%) patients. An analysis of factor s associated with mortality was carried out. Multiple logistic regression, Quasi-Newton measurement method, ROC analysis were used, the critical significance level was 0.05.

Results. According to the conducted study data, a statistically significant increase in the chance of a fatal outcome was revealed in individuals with a history stroke (odds ratio (OR) 2.47 [1.06-5.75]), with a body mass index (BMI) equal to or higher than 32.4±6.8 kg/m2 (OR 1.07 [1.01-1.14]), with an increase in the ventricular rate (VR) of AF equal to or higher than 84.2±15.4 beats per minute (OR 1.02 [1.00-1.04]) and the risk of thromboembolic complications according to the CHA2DS2 VASc scale equal to or higher than 4.3±2.3 points (OR 1.12 [1.04-1.21]). A decrease in creatinine clearance (CC) according to Cockcroft-Gault was associated with a high risk of adverse outcome (OR 0.99 [0.98-1.00]). At the same time, the fact of irregular intake of anticoagulant therapy was associated with a high probability of death, but did not depend on which anticoagulant was prescribed.

Conclusions. According to the results of a complex analysis it was revealed that patients with AF who have a history of stroke, high values of BMI, ventricular rate AF, CHA2DS2 VASc were more often having an unfavorable outcome.
Nonfluoroscopic catheter ablation of tachyarrhythmias in patients with antiarrhythmic devices
Authors: Kropotkin E. B. , Ivanitskiy E. A. , Gorton T. A. , Sakovich V. A.
Published: December 2024

Aim. To assess safety and effectiveness of zero fluoro catheter ablation (CA) of tachyarrhythmias in patients with antiarrhythmic device.

Methods. One hundred ninety-seven patients with implanted antiarrhythmic device and indication for catheter ablation of tachyarrhythmias were included in retrospective study. In control group of patients n=63 (mean age 65.5±11.9 years) all procedures were performed under fluoroscopic guidance. In a study group, n=134 (mean age 66.1±15.6 years) all procedures were performed without the use of fluoroscopy. To reconstruct 3D anatomy we used navigation systems: magnet and impedance. In some cases we used intracardiac ultrasound. In the first group there were 65% of patients with pacemakers, 4.8% patients with implantable cardioverters-defibrillators and 30.2% of patients had cardiac resynchronization systems. In second 70.1%, 12.7% and 17.2% respectively. In control group CA was performed within 24 hours after device implantation in 13 patients (20.6%), in study group - 23 (17.2%). In the rest cohort of patients mean period between device implantation and CA was 29.26±28 months - in control group, 38.8±39 months. Antiarrhythmic device programming was performed before and right after CA.

Results. Interventional catheter procedure was performed in 98.4% of patients in control group and in 98.5% of patients in study group. Radiation exposure in control group was 0.24 mZv, in study group 0 mZv. There were no conversions from zero fluoroscopy procedure to X -ray controlled due to different reasons. In control (fluoroscopy controlled) group 8 hours after CA ventricle lead dislodgement was diagnosed. Antiarrhythmic device in this patient was implanted 6 days before CA. There were no lead dislodgements or cardiac pacing disorders in study group.

Conclusion. Zero fluoroscopy CA of tachyarrhythmias in patients with antiarrhythmc device is as safe and effective as standard fluoroscopy controlled procedure.
Catheter ablation of atrial fibrillation in patients with systolic left ventricular dysfunction
Authors: Khuziakhmetov R. D. , Shishkina E. A. , Kadyraliev B. K. , Belov V. A. , Azizov S. N. , Khlynova O. V.
Published: December 2024

Atrial fibrillation (AF) is the most common arrhythmia among the adult population, affecting up to 2% of the population. Among patients with chronic heart failure (CHF), the prevalence of AF reaches 12.3%. The presence of common risk factors and pathophysiological mechanisms of AF and CHF development lead to the frequent combination of these two pathologies, which has a negative impact on the course of the underlying disease and further prognosis, increasing the chances of adverse outcomes such as stroke, myocardial infarction, and cardiovascular mortality. The results of most randomized studies indicate that interventional treatment of AF in patients with CHF and intermediate to low left ventricular ejection fraction (LV) contributes to reducing the functional class of CHF and improving quality of life, but at the same time, there is currently no consensus on the effectiveness, safety, and extent of catheter intervention. In this review, we attempted to summarize the literature data regarding the outcomes of interventional treatment of AF in patients with systolic LV dysfunction.
Systolic, diastolic, and pulse blood pressure during premature ventricular contractions: relationship with characteristics of ectopic beats
Authors: Shubik Yu. V. , Korneev A. B. , Baturova M. A. , Morozov A. N. , Pivovarov V. V. , Zaytsev G. K. , Tikhonenko V. M. , Kormilytsin A. Yu. , Gordeeva M. V. , Berman M. V.
Published: December 2024

The aim is to assess the relationship between systolic, diastolic, and pulse blood pressure (SBP, DBP, PBP) during ventricular extrasystoles (VE) and the individual characteristics of ectopic beats.

Methods. The primary method of investigation was BP measurement for each heartbeat. Inclusion criteria were the presence of ≥10000 monomorphic VE per day. A total of 53 patients were included, either without structural heart changes or with minimal structural alterations. The mean of systolic, diastolic, and pulse BP (SBP, DBP, and PBP) during VE (SBP VE, DBP VE, PBP VE) and during post-extrasystolic sinus contraction (post VE SBP, post VE DBP, post VE PBP) were calculated for each patient as fractions of 1.0.

Results. The QRS complex width in VE originating from the right ventricular outflow tract is greater than from the left ventricular outflow tract; fragmentation of the QRS complex is more commonly observed in these VE. Significant correlations were observed between SBP VE and mean coupling interval (CI), PBP VE and CI, and SBP VE and PBP VE, though not between DBP VE and CI. DBP VE was significantly associated with VE count and daily VE percentage, while PBP VE was associated with left ventricular ejection fraction. It has been shown that post-VE SBP and post VE DBP are lower, while post VE PBP is higher compared to the corresponding parameters of sinus beats preceding the VE. Significant relationships were found between post VE SBP and post VE PBP, the duration of the post-extrasystolic pause, and the presence of paired VE; between post VE DBP and post VE PBP, DBP VE, CI VE, the presence of non-sustained ventricular tachycardia, and daily VE percentage; between post VE PBP and DBP VE, the presence of non-sustained ventricular tachycardia, daily VE percentage, and post-extrasystolic pause duration. Post VE PBP was equally determined by values of post VE SBP and DBP.

Conclusion. With the shortening of the VE coupling interval, its SBP decreases, while DBP increases slightly, which may determine its hemodynamic significance. In post-extrasystolic sinus beats, both SBP and DBP decrease.
Syncope, asystole and atrioventricular block in a child with breath-holding spells: clinical case
Authors: Makarov L. M. , Komolyatova V. N. , Kiseleva I. I. , Dmitrieva A. V.
Published: December 2024

A case of a child with the breath-holding spells (BHS), atrioventricular block and long pauses of heart rhythm till 12 sec is presented. The attacks began at 1 year and completely stopped at 3 years. A typical ECG pattern for BHS is identified. The issues of therapy and the need for implantation of pacemaker are discussed.
Risk stratification for ventricular tachyarrhythmias after cardioverter-defibrillator implantation for primary prevention of sudden cardiac death: results of the IDEAL single-center prospective study
Authors: Ilov N. N. , Palnikova О. V. , Stompel D. R. , Zorin D. А. , Romantsov Е. I. , Terent’eva М. G. , Abdulkadyurov А. М. , Paskeev D. R. , Kulikova E. A. , Klimchuk D. О. , Petrova О. V. , Nechepurenko А. А. , Kolesnikov V. N. , Boytsov S. А.
Published: December 2024

Aim. The aim of this study was to develop additional selection criteria for implanted cardioverter-defibrillator (ICD) implantation in the primary prevention of sudden cardiac death (SCD) based on the risk stratification for the development of sustained ventricular tachycardia (VT).

Methods. The study included 451 patients with heart failure and reduced left ventricular ejection fraction (HFrEF) who were referred for ICD implantation for primary prevention of SCD. Participants underwent pre-implantation screening of clinical, instrumental, and laboratory parameters, followed by prospective observation for 24 months to record the first occurrence of sustained VT or justified ICD therapy. To achieve the study’s goal, training and test samples were formed.

Results. The arrhythmic endpoint was recorded in 84 patients (26%) in the training group and in 35 patients (27%) in the test group. Univariate analysis identified 11 factors with the highest predictive potential (p<0.1) associated with the occurrence of the studied endpoint. These included clinical data: coronary artery disease, arterial hypertension, resting heart rate >80 bpm; electrocardiographic parameters: complete left bundle branch block according to Strauss criteria, P-wave duration (lead II) >120 ms, or the presence of atrial fibrillation (in the case of persistent form), index of cardiac electrophysiological balance (ICEB) >3.1; echocardiographic parameters: presence of eccentric left ventricular hypertrophy, global longitudinal strain ≥ minus 6%; laboratory markers: galectin-3 >12 ng/ml, sST-2 >35 ng/ml, NT-proBNP >2000 pg/ml. Based on the regression coefficients, points were assigned to each factor, and the sum of these points determined the value of a new proposed index - the arrhythmic risk index (ARI). ARI values >5 points predicted the two-year likelihood of VT in HFrEF patients with a sensitivity of 78.6% and specificity of 64.3% (AUC=0.788±0.028 with 95% confidence interval (CI): 0.732-0.843; p=0.0001). The application of ARI in the test group demonstrated good model performance in predicting two-year VT risk (AUC=0.652±0.053 with 95% CI: 0.547-0.757; p=0.008).

Conclusion. Based on the obtained results, a predictive index was developed, allowing for personalized and timely risk assessment of VT in patients with HFrEF.
Industrial Kitchen Manufacturer Service Management
Authors: Yüzkat Mecit , Bakır Çiğdem
Published: December 2024

As in all production sectors, it is important to meet customer demands in a timely and accurate manner in the kitchen industry. This study is one of the rare studies that encourage the use of ERP system-based kitchen products, especially SAP, according to customer demands. In our study, a system that re-evaluates the customer communication approach for a company engaged in industrial production, covering the process from the sale of the product to the end user and the technical service process after the product sale, was discussed. Thanks to this system, the company will be able to deliver and sell the spare parts it owns or produces to service managers. At the same time, they will be able to report all commercial transactions in the system, create financial records and store them digitally in their own records. Our system works integrated with Google maps in order to reach the customer in a timely and cost-effective manner during spare parts supply processes. The system we will design; It includes call center application, spare parts order application, malfunction work order application, invoice cockpit application, stock inquiry application. The system generally consists of two parts: Front End and Back End. In our study, accuracy criteria were used to evaluate the performance of the system. Thanks to this system, product delivery times are shortened and customer satisfaction increases. Making some changes to the system we recommend will help many organizations in other sectors to improve their ERP systems and effectively prevent the problems encountered.
Prioritization of Regression Test Cases Based on Machine Learning Methods
Authors: Kıran Selçuk , Emre İlkim Ecem , Taşdelen Selen
Published: December 2024

Due to resource and time constraints involved in the software testing process, it is not possible to implement all test scenarios for each release. Test scenarios can be prioritized according to certain criteria defined by the developers to ensure effective execution of the testing process and detection of errors. This study investigated whether machine learning based models could be used to prioritize test scenarios created in regression testing. It is attempted to determine which tests can be prioritized for execution based on different independent variables. In total, each of the 964 test scenarios in the dataset was labelled as minor (482) and major (482) by two experts. In the models, the number of related requirements, the number of related errors, and the age of the scenario were used as independent variables, and the scenario classes labelled as minor - major were taken as the target variable. The scenarios were pre-processed using natural language processing techniques and different machine learning algorithms were used for model development. In the classification based on test scenarios, the random forest algorithm showed the best performance with a F1-score of 81%. In the classification based on the number of related requirements, the number of interrelated errors, and the age of the test scenarios, the random forest model once again demonstrated the highest success rate at 79%. This study demonstrates that machine learning techniques offer a variety of models for test case prioritization.
Rehabilitation of Concrete Structures - A Review
Authors: Elkhatib Lelian , Khatib Jamal , Fırat Seyhan , El Hassan Hilal , Elkordi Adel
Published: December 2024

Concrete is considered as a material that is heavily relied on in the construction of infrastructures, buildings, bridges, highways, etc. Concrete structures need to be checked and maintained periodically in order to avoid the progression of any cracks to the concrete elements. However, there are some circumstances and problems that causes the deterioration of the concrete structure either totally or partially. In such cases, the repairing techniques, methods and materials cannot serve as a good solution to stop and solve the deterioration. Thus, rehabilitation and retrofit techniques arise to be the only choice that can solve the deterioration of concrete structures. The progression and initiation of damages into the concrete sections may cause a reduction in the durability and strength of the system. Rehabilitation techniques are used to stop the damages and enhance the performance of deteriorated concrete structures where they can restore their strength and durability. These damages may occur due to the ingression of alkaline water, sulfate attack, chloride attack, corrosion of steel bars, freeze and thaw cycles, environmental changes, fire attack, thermal changes, etc. Several measures shall be taken into account while choosing the rehabilitation technique. The environment surrounding, the section type, the properties of the section that must be enhanced, the location of the concrete members that need rehabilitation, all these factors shall be taken into consideration before choosing any rehabilitation technique since each one can be used in specific places. Different equations are used in order to calculate the properties and capacities of members’ after being rehabilitated.
Perception of animal welfare in students of the animal health management and welfare of veterinary medicine course
Authors: Medina-Lerena Miriam Susana , Villanueva-Ochoa Andrés , Ramírez-Fernández Luis Rodolfo , De la Rosa-Arana Jorge Luis
Published: January 2025

The students' perception provides information to design strategies aimed at teaching animal welfare, creating awareness of the quality of animal life, creating values in the student towards respect and care for animals. The objective was to analyze the perception of two groups in MSBA of Veterinary Medicine about the importance of animal welfare, use and protection of animals. 91% from Jalisco, 8% from other states and 1% foreign (data from 51 women and 36 men). The performance of both groups was favorable. 100% have a basic concept and consider animal welfare important. There are no differences between groups, in relation to animal welfare, being an essential issue that provides values and ethics. There is a relationship between animal welfare and veterinary medicine, it creates awareness to protect the health of animals, correct management and the conditions necessary for a better quality of life.
مُستوياتُ الاحتباكِ في النصِّ اللغويِّ: النصّ- الجُملة- المُفردة
Authors: Mustafa Sulaf
Published: December 2024

الأهداف: الاحتباك في مفهومه العامّ إيجازٌ بحذفٍ متقابلٍ في مستوى دلالات النصّ، لكنّه يمكنُ أن يجري في المستوى النحويّ في الجملة، فيُؤشّرُ كسرًا لقوانين التساوق في محور التأليف، مثلما يجريَ في المستوى الصرفيّ في المفردة ليُظهر خرقًا لقوانين محور الانتقاء، والبحث في هذا المضمار يلقي الضوء على ظاهرة تجمع أشتاتًا تُدرس في أنحاءَ متعدّدةٍ فيلمُّ شملها تحت مظلة واحدة بالمنظور الأوسع للاحتباك.
المنهجيّة: يجري الاحتباك من زاوية النظر التي سنعالجُها دلاليًّا في فضاءِ النصِّ الأرحب بحذفٍ متقابلٍ تدلُّ عليهِ علاقاتٌ مفهوميّةٌ؛ وتجري نحويًّا في مستوى التركيب، كما تجري في المستوى الصرفيّ بالحذف بين لفظتين تحذف الصيغة من إحداهما والمادة المعجمية من الأخرى.
النتائج: على كثرة من تناول الاحتباك لم نجد من الباحثين من حدّد المستويات التي تجري فيها الظاهرة تحديدًا دقيقًا يوضّح حاصل الاحتباك، الذي يجري على غرار الحذف في المعادَلات، والمؤلفات المختصة قديمًا وحديثًا تخرج الكلام في أمثلة الظاهرة مخرجًا واحدًا لا يفرّق بين المستوى الدلاليّ والتركيبيِّ والإفراديّ الصرفيّ، واعتماد هذا التقسيم ينبّه على الظواهر التي لم تكن معدودة في الاحتباك، مع أنّها تقاس عليه بوضوحٍ.
الخلاصة: يمكنُ تكثير المعاني من طريق الحذف المتقابلِ بين طرفين في مستوى لفظةٍ مفردةٍ واحدةٍ، وهذا ما يجوز أن يُصطلح عليه بالاحتباك الصرفيّ، في حين يجري الحذف المتقابل في كثيرٍ من الظواهرِ النحويّةِ على نحوٍ مطّردٍ، كما في استعمال المصادر وأسلوب الشرط والتضمين، بما يمكنُ أن يُصطلح عليه بالاحتباك التركيبيّ. وقد لوحظ أنّ قلّةً من الباحثين أشاروا إلى وقوع الاحتباك في مستوى النصّ بأكمله، في علاقة الإجمال والتفصيل المتبادلة بين النصوص في بنيتها الكبرى.
Relationships and Dynamic Feedback Effects between Financial Market Risks and Macroeconomic Stability Variables in Jordan
Authors: Abu Roman Naseem
Published: January 2025

Objectives: This study examines the complex relationship between financial market risk (Financial Market Risk and three indicators of macroeconomic stability—the unemployment rate, headline inflation, and breakeven inflation using data ranging from January 2023 to December 2022.
Methods: Using an asymptotic vector autoregression (VAR) optimised by the Schwartz information criterion (SIC) and a Maximum likelihood two-state Markov switching process, this study investigates the dynamic interactions and feedback effects between these macroeconomic variables in relation to log shifts in Financial Market Risk.
Results: The results reveal different patterns in the impact of financial market risks on unemployment and inflation, as the results show a large and positive impact of financial market risks on unemployment. The results of the study indicate the presence of heterogeneous effects of financial market risks on inflation and the existence of a relationship between financial market risks and indicators of macroeconomic stability. There is also a relationship between forced migration and low inflation, and these trends indicate the existence of a dynamic between the market’s perception of risks and the expected development of inflation. The relationship between the rate of forced migration and break-even inflation rates implies a correlation between the market's perception of risk and long-term inflation expectations.
Conclusions: This study concludes that concerns about a slowing economy (higher unemployment) and falling inflation (market-implied inflation) are the main factors worsening market risk.
Interactive integration into magazine cover designs
Authors: Abbas Fadhil Shahid
Published: December 2024

يعتبر الاندماج التفاعلي وسيلة اتصال حديثة يستخدمها المصمم لنقل الافكار، فضلا عن يجمع بين المتعة الجمالية للمتلقي لما تمتلكه من المرونة في دمج الصوت مع الصورة لأجل ايصال رسالة الاعلانية سواء اخبارية او ايضاحية تتلخص مشكلة البحث بالتساؤل الآتي: ما هو الاندماج التفاعلي في تصميم أغلفة المجلات؟ـ وتأتي أهمية البحث كونه يسلط الضوء على موضوع الاندماج التفاعلي من ناحية فكرية وعملية.وتناول الإطار النظري مبحثين، الأول الاندماج التفاعلي، والمبحث الثاني: تصميم اغلفة المجلات، مع الخروج بمؤشرات لهذا الإطار النظري، وضمت إجراءات البحث مجتمع البحث وعينات البحث وأداته، واتبعنا بتحليل ثلاثة نماذج مختارة وختم البحث بالنتائج والاستنتاجات ومنها:1. يسهم الاندماج التفاعلي في الاعلان تحقيق جذب واثارة الاهتمام لدى المتلقي اتجاه الاعلان فضلا عن الوضوح والمقروئية.2. لتنوع استخدام الصور الرقمية والرسوم المتحركة دورا في ابراز الاندماج التفاعلي عن طريف القيم اللونية المتنوعة والانسجام الكلي داخل مكونات التصميم. الكلمات المفتاحية: الاندماج، التفاعل، التصاميم، اغلفة المجلات.
IN THE PERSPECTIVE OF CULTURAL INTEGRATION: THE DEVELOPMENT STATUS AND REASONS OF DIVERSE CULTURE IN MALAYSIA —— TAKE MAHUA CULTURE AS AN EXAMPLE
Authors: Gao WenJun , Khalid Nur Arjun
Published: January 2025

After the end of the Second World War, the multicultural policies of developed Western countries have generally adopted a policy of cross-fertilization of assimilation, pluralism and integration in response to their respective national conditions. Based on the study of the development of multicultural integration in developed Western countries, this paper examines the current situation of multicultural development in Malaysia and explores the reasons for it from the perspective of cultural integration. As one of the Southeast Asian countries, Malaysia has had close exchanges with China since ancient times, and the Chinese are also an important force in the modernization of their country. Therefore, this paper applies the literature research method to explore the manifestation of multicultural integration in Malaysia by taking the phenomenon of Malaysian localization of the Malaysian-Chinese culture as an example, and further explores the historical reasons for the formation of the phenomenon of multicultural integration in Malaysia, and discusses the history of the exchanges of the two ethnic groups, the Malaysian-Chinese, from the ancient times to the modern times, and from the trade to the emigration.
INVESTIGATING THE ROLE OF STAKEHOLDERS IN FOSTERING MOSQUE TOURISM IN ATTRACTING TOURISTS TO VISIT MALAYSIA
Authors: Tengku Mansur Tengku Elvirozita , Mohd Sanip Mohd Nor Ahmar , Abdul Majid Noraziela , Abdul Aziz Maimunah
Published: January 2025

This paper attempted to appraise the role of stakeholders in encouraging mosque tourism in a tourism destination. As a niche area in Islamic tourism industry, mosque tourism has gained a lot of attention from the tourists in the past few years. Since mosque tourism popularity is expanding and growing, the challenges face by the stakeholders are becoming more complicated due to rapid changes in the tourism industry itself along with competitive mosque tourism destinations. Therefore, the objective of this study is to investigate the role of stakeholders in fostering mosque tourism in attracting tourist to visit Malaysia. Additionally, this study also seeks to identify the salient factors that attracts tourists to visit the mosque in Malaysia from the perspectives of the industry players including travel agencies, hoteliers and local authorities who are the backbone of the hospitality and tourism sector in Malaysia. By employing qualitative approach of thematic analysis, the paper went on to analyse the issues and concepts of the forthcoming study through a number of literatures of various disciplines. The result of this study has shown that cultural and educational significance, architectural marvel, historical value, religious factor, word of mouth, marketing and promotion plays significant role in influencing tourists to visit mosque in Malaysia. In regard to the role of stakeholders, it was discovered that mosque management and infrastructure development, collaborative efforts, educational awareness, and cultural preservation and community engagement are the four categories that was vital in fostering mosque tourism in Malaysia. Hence, future research may become an important platform for various hospitality and tourism stakeholders in developing the strategies and marketing tools to increase tourist’s participation in mosque tourism in Malaysia. The study will also be relevant to local authorities to design effective mechanism to promote Malaysian mosque tourism industry as another dimension of attraction to visit Malaysia.
AN ANALYTICAL STUDY OF THE FACTORS AFFECTING THE CHOICE OF TOURISTS FOR HOTELS (A FIELD STUDY OF A SAMPLE OF TOURISTS WHO GO TO THE STATE OF KERBELA – IRAQ)
Authors: Toual Hiba , Al-Shaibani Mohammed Abd Ali Jasim , Almasoodi Muthana Faaeq
Published: January 2025

This study aimed to identify the impact of a group of factors (The purpose of the visit, the visitor's concept of value, social and economic factors, race or religion) on the choice of hotels by tourists, to achieve this, we selected a random sample (250) from the study population, which consists of all tourists visiting Karbala Governorate - Iraq -, this take place during the end of 2023 and the beginning of 2024 a questionnaire was distributed electronically to collect data. The most important findings of the study are that there is a significant relationship between the factors (The purpose of the visit, the visitor's concept of value, social and economic factors, race or religion) That affect needs of tourist guests and between evaluating and choosing the hotel. The study provided, through the results, a set of recommendations, the most important of which was: Renewal and development of hotel interior design, Development in complementary services (restaurants, cafeteria...) Since we met many foreign guests, the menu had to be diversified to suit their desires.
INTELLECTUAL CAPITAL MODEL FOR MUSLIM-FRIENDLY TOURISM AND HOSPITALITY SERVICES: QUALITATIVE PERSPECTIVE
Authors: Kamaluddin Amrizah , Hambali Siti Syaqilah , Sa’ad Shukriah , Pratama Bima Cinintya , Innayah Maulida Nurul , Fitriati Azmi
Published: January 2025

The current study focuses on Muslim Friendly Tourism and Hospitality (MFTH) services, as these rising services offer new and exciting opportunities for recovering and enhancing economic growth in the tourism industry. Intellectual capital is a firm's resource that has been proven to assist in creating a competitive advantage. Thus, strategically managing intangible assets, such as intellectual capital, is vital to gain a competitive edge. The study's main objective is to explore the indicators of intellectual capital that the MFTH service providers should possess to ensure the firm's sustainability. In addition, a new intellectual capital model, which comprises human capital, structural capital, relational capital, and innovation capital, suitable for MFTH service providers is proposed. A qualitative approach was applied through face-to-face interviews to obtain an in-depth perspective of intellectual capital in MFTH services with the tourism authorities and the academics.
Anadolu’da Kırsal Yerleşim ve Konut Mimarisinde Yabanlı Türkmen Aşireti Köyleri
Authors: Öztürk Mehmet Kaan , Akın Emine Saka
Published: December 2024

Kırsal yerleşimlerin fiziksel ve mekânsal şekillenmeleri bulundukları coğrafyanın doğal yapısı ve sosyo-kültürel çevre dinamiklerine bağlı olarak gelişir. Bu dinamiklerle özgün yerleşim ve mimari formlarını ortaya koyan kırsal yerleşimler, teknolojinin gelişmesi ile değişmeye başlamıştır. Kırsal yerleşimlerde teknolojinin gelişmesi üretim şekillerinin, ihtiyaç, beklenti ve taleplerin değişmesine neden olarak kırsaldaki insanları göç etmeye zorlamıştır. Göçlerle birlikte boşalan kırsal yerleşimlerin özgün, kimlikli mimarileri de bozulmaya başlamıştır. Bu çalışmanın amacı da göçler nedeni ile nüfusu iyice azalan Orta Anadolu’da Yabanlı Türkmen Aşireti’nin günümüze gelebilen 12 köyünün yerleşim morfolojisi ve bu köylerde yer alan 25 konut üzerinden kırsal konut tipolojisinin ortaya konulmasıdır. Bu amaca yönelik yapılan literatür çalışmasında kırsal konut ve Yabanlı Türkmen Aşireti köyleri hakkında bilgiler derlenmiş, nüfus bilgileri ve yerleşimlere ait hava fotoğrafları elde edilmiştir. Alan çalışması ile de köylerde gözlem, inceleme, görüşmeler ve rölöve çalışmaları yapılmıştır. Elde edilen tüm verilerin analizleri sonucunda Yabanlı Türkmen Aşireti’ne ait köylerin yerleşim morfolojisi, bu morfolojiye etki eden dinamikler ve geleneksel konut tipolojileri plan, cephe, malzeme ve yapım tekniği düzeyinde ortaya konulmuştur. Yapılan analizlerle Yabanlı Türkmen Aşireti’ne ait köylerin yerleşim morfolojisinin doğal çevre dinamiklerine ve zaman içerisinde nüfusunun ve üretim şekillerinin farklılaşmasına bağlı olduğu; kırsal konut mimarisinde ise yakın çevreden elde edilmiş malzeme ile inşa edilmiş, tarım ve hayvancılığa dayalı sofalı mekân kurgusuna sahip plan tipolojisi görülmüştür. Ancak son yıllarda yaşanan göçler köylerin boşalmasına ve kırsal konut yapılarının âtıl ve bakımsız kalmasına; gelişen teknolojiye ve konfor ihtiyaçlarına bağlı olarak köylerde kalan insanların plansız bir şekilde özgün olmayan betonarme konut yapıları inşa etmelerine neden olarak hem kırsal yerleşim morfolojilerini hem de özgün ve kimlikli mimarilerinin yok olmasına neden olmaktadır. Bu nedenle özgün ve kimlikli kırsal yerleşimlerin korunması ve geleceğe aktarılması için ivedilikle envanterlerinin çıkarılarak çok disiplinli çalışmaların yapılması gereklidir.
First modern Russian plasma-derived coagulation factor VIII concentrate (Eytoplasm): Results of clinical study of pharmacokinetics, efficacy and safety
Authors: Zorenko V. Yu. , Makhmudova A. D. , Schiller E. E. , Polyanskaya T. Yu. , Berger I. V. , Juraeva N. T. , Korolyova A. A. , Mamatov S. M. , Narbekov T. O.
Published: December 2024

Introduction. Replacement therapy with coagulation factor VIII concentrates remains the standard of care for patients with hemophilia A. In 2023, the drug Eytoplasm, the first modern plasma-derived coagulation factor VIII concentrate developed in the Russian Federation, was authorized for medical use in the Russian Federation.

Aim: to study the efficacy, safety, immunogenicity, and pharmacokinetic properties of Eytoplasm.

Methods. A multicenter, prospective, open-label clinical trial was conducted in 55 patients over 12 years of age with severe hemophilia A who had previously received treatment with coagulation factor VIII concentrates (at least 150 exposure days). All patients received the drug for prophylactic treatment 2–3 times a week; the treatment duration was 6 months (at least 50 exposure days). In addition, the drug was used to treat bleeding. Ten patients underwent 10 surgical interventions (2 major and 8 minor). Pharmacokinetic parameters were determined after the first administration of the drug to patients and after 6 months of therapy.

Results. Eytoplasm pharmacokinetics properties are comparable with other plasma-derived coagulation factor VIII concentrates. No bleeding was recorded in 75.9% of patients. In 92.3 % of patients, a single administration of the drug was sufficient to stop an episode of bleeding. In all participants who completed the study, the residual activity of coagulation factor VIII 48–72 hours after drug administration was at least 1 %. Positive dynamics of APTT was showed during the study. Serious adverse events, allergic reactions, thrombotic and thromboembolic complications were absent in patients. In 3 patients, 4 adverse events associated with the use of the drug were registered: 2 cases of increased serum concentration of direct bilirubin and 2 cases of headache. An inhibitor to coagulation factor VIII was not detected in any patient. In none of the patients who did not have antibodies to parvovirus B19 before the first dose of Eytoplasm, antibodies were detected after 6 months of therapy.

Conclusion. Eytoplasm is an effective option for the prevention and treatment of bleeding, and during surgical interventions, including major ones, in patients with hemophilia A. The drug has a favorable safety profi le; its use was not associated with the formation of inhibitory antibodies, allergic reactions, thrombotic and thromboembolic complications.
Treatment of refractory and recurrent T-lymphoblastic lymphomas from progenitor cells in children and adolescents: current problem state and future perspectives
Authors: Pavlova T. Yu. , Valiev T. T. , Varfolomeeva S. R.
Published: December 2024

Introduction. Despite the successes achieved in the treatment of lymphoblastic lymphomas from progenitor cells (LBL), an important task in improving survival rates in the group of patients with T-cell lymphoblastic lymphomas (T-LBL) remains. The group of special unfavorable prognosis consists of patients with relapses and refractory forms (r/r) of T-LBL.

Aim: to present a literature review on the use of targeted and immune drugs, as well as cellular and transplant methods in the treatment of r/r T-LBL.

Main findings. Modern clinical onco-hematology has a broad spectrum of methods for the treatment of r/r T-LBL, including intensive chemotherapy, targeted, transplant and CAR-T technologies, but even a combination of these methods, currently, does not make it possible to achieve optimistic results in this prognostically unfavorable group of patients. It is possible that the creation of targeted drugs focused on signaling pathways (NOTCH, PI3K/ACT/mTOR, JAK/STAT and MAPK) with modern therapeutic potential could improve patient survival rates.
Efficacy of anti-CD19 CAR-T therapy after bispecific monoclonal antibody (CD19/CD3) therapy in a patient with relapsed Ph-positive acute lymphoblastic leukemia with a massive extramedullary component
Authors: Aleshina O. A. , Akezheva K. A. , Eroshenkov D. Yu. , Vasilyeva A. N. , Shchekina A. E. , Nalbandyan S. A. , Galstyan G. M. , Bogolyubova A. V. , Galtseva I. V. , Kovrigina A. M. , Parovichnikova E. N.
Published: December 2024

Introduction. Patients with relapsed/refractory (r/r) Ph-positive acute lymphoblastic leukemia (ALL) have a poor prognosis and limited treatment options. New promising immunotherapies using CAR T cells or monoclonal antibodies (blinatumomab, inotuzumab/ozogamicin) in combination with tyrosine kinase inhibitors are being used for this group of patients. However, long-term results have not been studied when relapse or refractoriness develops after the use of one of these methods.

Aim: to present a clinical observation of the use of anti-CD19 CAR T therapy after blinatumomab therapy in a patient with a relapsed course of Ph-positive acute lymphoblastic leukemia.

Main findings. A 28-year-old patient was first diagnosed with Ph-positive B-ALL (transcript p210) in 2014. In the 1st line of treatment he was treated with therapy according to the protocol ‘ALL-2009’ with imatinib and allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, 2 months later the first molecular relapse was detected, and imatinib was replaced by dasatinib. In November 2016, a second relapse was diagnosed. In 2017, a third relapse with testicular involvement and T315I mutation was diagnosed, and therapy with ponatinib was initiated. In 2022, a 4th medullary relapse developed, and therapy with blinatumomab (5 courses) in combination with ponatinib was performed. After the 5th course of therapy, the appearance of leukaemides was noted, and asciminib was added to the therapy. However, no clinical effect was noted. The patient was treated with anti-CD19 CAR T therapy. A complete response to CAR T-cell therapy was confirmed on day 28 after CAR T administration. Further follow-up, over the course of one year, demonstrated stable clinical response and persistence of CD3-positive CAR T-cells. This case report of anti-CD19 CAR T cell therapy in a patient with CD19-positive combined relapse with massive extramedullary component after blinatumomab therapy demonstrated long-term efficacy with a 1-year follow-up.
Tingkat Pengetahuan tentang Xerostomia pada Pasien Lansia di Puskesmas
Authors: Ariani Dwi , Az Zahra Septiana A.
Published: December 2024

Abstract: Xerostomia is defined as a subjective complaint of dry mouth associated with salivary gland hypofunction, mostly found among elderly. This study aimed to obtain the level of knowledge about xerostomia in elderly patients at Pasir Jaya Health Center, Cikupa, Tangerang. This was a descriptive study with a cross-sectional design using a questionnaire method (google form) consisting of an overview of the sociodemographic and health characteristics of respondents, Abbreviated Mental Test (AMT), and Summated Xerostomia Inventory Indonesia Version (SXI-ID) instruments. Respondents' knowledge was classified into three-level scales, namely good, fair and low. Data were processed with SPSS software. The results obtained 106 elderly patients as respondents. Based on the distributed questionnaires, 56 respondents (53%) had good level of knowledge and 50 respondents (47%) had moderate level of knowledge. Respondents with systemic condition as many as 76 patients (71.70%), xerogenic drug consumption 76 patients (71.70%), and status as smoker 28 patients (26.42%). In conclusion, among elderly patients at Pasir Jaya Health Center, Cikupa, Tangerang, the level of knowledge about xerostomia is classified as good and fair. The most frequent factors related to xerostomia are systemic condition and xerogenic drug consumption.
Keywords: level of knowledge; xerostomia; elderly
  
Abstrak: Xerostomia di definisikan sebagai keluhan subjektif dari mulut kering yang berhubungan dengan hipofungsi kelenjar saliva, terutama dijumpai pada lanjut usia (lansia). Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan tentang xerostomia pada pasien lansia di Puskesmas Pasir Jaya Kecamatan Cikupa Kabupaten Tangerang. Jenis penelitian ialah deskriptif edngan desain potong lintang menggunakan metode kuesioner (google form) yang terdiri dari gambaran umum karakteristik sosiodemografi dan kesehatan responden, Instrumen Abbreviated Mental Test (AMT), dan Summated Xerostomia Inventory Indonesia Version (SXI-ID). Pengetahuan responden digolongkan dalam skala tiga tingkat, yaitu baik, cukup dan rendah. Data diolah dengan software SPSS. Hasil penelitian mendapatkan 106 pasien lansia sebagai responden. Berdasarkan kuesioner yang didistribusikan sebanyak 56 responden (53%) dengan tingkat pengetahuan baik dan 50 responden (47%) dengan tingkat pengetahuan cukup. Responden dengan kondisi sistemik sebanyak 76 orang (71,70%), minum obat xerogenik 76 orang (71,70%), dan status perokok saat ini 28 orang (26,42%). Simpulan penelitian ini ialah pengetahuan mengenai xerostomia pada pasien lansia di Puskesmas Pasir Jaya Kecamatan Cikupa Kabupaten Tangerang, tergolong baik dan cukup. Faktor yang paling sering menyebabkan terjadinya xerostomia pada pasien lansia yaitu kondisi sistemik dan konsumsi obat xerogenik.
Kata kunci: tingkat pengetahuan; xerostomia; lanjut usia
DAMPAK PENGEMBANGAN EKOWISATA DI SEKSI WILAYAH III TANJUNG HARAPAN TAMAN NASIONAL TANJUNG PUTING TERHADAP SOSIAL BUDAYA MASYARAKAT DESA WISATA SEKONYER
Authors: Siregar Tesalonika Purnama , Joko Mijiarto
Published: December 2024

This study aims to identify and analyze these impacts using a qualitative approach. Data were collected through in-depth interview techniques, observation, and documentation. The results of the study indicate that ecotourism activities have a positive impact on the local community. First, ecotourism increases community knowledge and insight into environmental management and sustainability-based tourism potential. Second, community awareness of local natural and cultural wealth is increasing, encouraging the preservation of traditional cultural values. Third, the social status of the community increases through active participation in tourism activities. Fourth, it also has an impact on foreign language skills, especially English, as a need for interaction with tourists. Fifth, community empowerment can be seen from the emergence of new economic opportunities, such as homestay management, local crafts, and tour guide services. This study emphasizes the importance of synergy between ecotourism managers, the government, and the community to maintain long-term benefits for the sustainability of ecotourism and the welfare of the local community.
PENERAPAN PRINSIP TRANSPARANSI BADAN KEPEGAWAIAN DAN PENGEMBANGAN SUMBERDAYA MANUSIA DALAM PELAKSANAAN REKRUTMEN PPPK DI KABUPATEN MUNA BARAT
Authors: Suriyani BB  , Asriani  , La Ode Muhammad Elwan  , Risky Wilda Yanti
Published: December 2024

This study aims to determine how the Application of the Principles of Transparency of the Civil Service Agency and Human Resource Development in the Implementation of PPPK Recruitment in West Muna Regency. The method used in this research is descriptive qualitative research with data collection through observation, interviews, and documentation. Based on the research results, The implementation of the principle of transparency in the BKPSDM of West Muna Regency in the implementation of PPPK recruitment has been running but not yet optimal. Although tasks have been carried out well, the late response to information and the difficulty of the community in understanding the registration procedures and accessing information through the website show that transparency still needs to be improved. In general, the provision of clear information and easy access to information are still areas that need improvement to ensure effective transparency.
Navigating languages and love: Exploring the perceived emotional weight of I love you among Third Culture Kids in Denmark
Authors: Rodríguez Bernal Lydia
Published: January 2025

This mixed-methods study contributes to understanding the emotional dynamics of a distinct, yet understudied, multilingual population: Third Culture Kids (TCKs). These individuals are typically raised in multilingual and nomadic households and are extensively socialised in English through international schools and expatriate communities. While prior research has focused on the emotional nuances of the phrase I love you in adult populations, a significant gap remains in understanding these nuances in other age groups, particularly in the context of transnational upbringing. This study addresses this gap by exploring the perceived emotional weight of the phrase in the linguistic repertoire of 276 TCKs enrolled in the InternationalBaccalaureate Program by examining the emotional dynamics shaped by their first language (L1,mainly a heritage language) and their frequent exposure to English (LX, acquired after L1) in an environment influenced by American culture, where the use of I love you is a daily phenomenon. Unlike previous studies, results indicated a combined heightened emotional weight of L1 and LX, challenging the traditional centrality of L1. Furthermore, multinomial logistic regression models revealed TCKs’ unique sociobiographical factors as the driving force behind their emotional perception. These findings contribute to understanding how sociobiographical features influence linguistic emotional perceptions and cross-cultural communication.
Leadership Commitment to Corporate Social Responsibility Sustainability and Project Performance in the Mining Industry in Kenya: A Case of Tata Chemicals, Magadi
Authors: Opondo Edward , Nderitu Wanjiru
Published: December 2024

Corporate social responsibility is a self-regulating business model that helps a company to be socially accountable to itself, its stakeholders and public. The objective of the study was to examine the effect of Leadership commitment to CSR sustainability performance in the mining industry in Kenya. Different theories and literature relating to the study were reviewed and the emerging knowledge gap identified. The research was conducted in the mining industry specifically within Tata Chemicals Magadi Limited (TCML). The target population was 300 respondents from different departments including marketing and supply chain (internally) and externally the population included women and young people. The researcher used stratified random sampling. From the possible 300 target population, stratified random sampling was employed to select a total of 72 sample population. This is 24% of the total population. The method used for data collection was quantitative design where a structured questionnaire was used to get the views. Both qualitative and quantitative process was used to analyze the data that was collected and compute the information using Statistical Package for Social Sciences (SPSS). The findings were presented to the panelists by use of power point presentation. The findings demonstrated that the R square value of the model was 0.399 indicating that 39.9% of the project performance is influenced by leadership motivation. The study therefore, concluded that leadership commitment is important to organization in terms of its influence on the implementation of CSR but its consistency with project performance has yet to be supported by the study. The study recommends that companies should focus on commitment to its employees as this is vital in achieving and retaining competitive advantage. The study also recommends company should select project members carefully to enhance its performance.  It also endorses that a similar study to be conducted on the influence of CSR initiatives on project performance on other industries.