bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Features of Acquired Resistance to Anti–PD-1 Therapy in Advanced Melanoma
Authors: Wang Daniel Y. , Eroglu Zeynep , Ozgun Alpaslan , Leger Paul D. , Zhao Shilin , Ye Fei , Luke Jason J. , Joseph Richard W. , Haq Rizwan , Ott Patrick A. , Hodi F. Stephen , Sosman Jeffrey A. , Johnson Douglas B. , Buchbinder Elizabeth I.
Published: April 2017

Anti–PD-1 therapy has improved clinical outcomes in advanced melanoma, but most patients experience intrinsic resistance. Responding patients can develop acquired resistance to anti–PD-1. We retrospectively reviewed 488 patients treated with anti–PD-1 from three academic centers and identified 36 patients with acquired resistance, defined as disease progression following objective response. The incidence, timing, disease sites, post-progression survival (PPS), and outcomes were evaluated descriptively. The acquired resistance cohort consisted of 67% with more than 1 feature of poor prognosis (stage M1c, elevated LDH, or brain metastasis), and 67% had previously received ipilimumab. Partial and complete responses were achieved in 89% (n = 32) and 11% (n = 4) of patients, respectively, and median time to resistance (progression-free survival; PFS) was 11.1 months (range 4.3–32.8 months). Most progression was isolated (78% of patients, n = 28) and occurred while receiving therapy (78%, n = 28). The median PPS was 12.8 months (range 0.1–51.8 months), and the median overall survival was 33.7 months. Among isolated progressors, 15 received localized therapy (12 with surgery, 3 with radiation). Patients with isolated versus systemic progression exhibited a trend for improved PPS (P = 0.081), and patients with an initial PFS ≥ 15 months showed significant PPS improvement (P = 0.036). Two patients experienced subsequent responses to anti–PD-1 resumption. In conclusion, acquired resistance to anti–PD-1 was frequently associated with excellent clinical outcomes and often presented as isolated progression amenable to localized therapy (surgery or radiation) or systemic progression sensitive to therapy resumption. Cancer Immunol Res; 5(5); 357–62. ©2017 AACR.
Neoadjuvant Chemotherapy with Gemcitabine plus Cisplatin in Patients with Locally Advanced Bladder Cancer
Authors: Niedersüss-Beke Dora , Puntus Thomas , Kunit Thomas , Grünberger Birgit , Lamche Michael , Loidl Wolfgang , Böhm Reinhard , Kraischits Nicole , Kudlacek Stefan , Schramek Paul , Meran Johannes G.
Published: April 2017

Background: Neoadjuvant chemotherapy with methotrexate-vinblastine-doxorubicin-cisplatin (MVAC) is the standard of care for muscle-invasive urothelial bladder cancer. Gemcitabine plus cisplatin (GC) shows similar efficacy with less toxicity in the metastatic setting and has therefore often been used interchangeably with MVAC. We report on the efficacy and safety of neoadjuvant GC in patients with locally advanced urothelial cancer. Materials and Methods: We prospectively evaluated 87 patients in 2 centers. Their median age was 68 years. Treatment consisted of 3× GC prior to radical cystectomy. The primary endpoint was pathologic response. The secondary endpoints were safety, progression-free survival (PFS), and overall survival (OS). Results: In all, 83 patients finished chemotherapy; 80 patients were evaluable for the primary endpoint. Pathologic complete response (pCR) was achieved in 22.5% and near pCR was seen in 33.7% of the patients. The 1-year PFS rate was 79.5% among those patients achieving ≤pT2 versus 100% among those patients achieving pCR or near pCR (p = 0.041). Five-year OS was 61.8% (95% CI 67.6 to NA). GC was well tolerated. Grade 3/4 toxicities occurred in 38% of the patients. There was no grade 3/4 renal toxicity, febrile neutropenia, or death. Conclusion: Neoadjuvant GC is a well-tolerated regimen. Although the pathologic response is lower than that reported with MVAC, our data support GC as a feasible option in the absence of a prospective randomized comparison, particularly for older patients, since its toxicity is lower than that of MVAC.
Retinopathy of Prematurity Is Associated with Increased Systolic Blood Pressure in Adults Who Were Born Preterm
Authors: Kistner Anna , Jacobson Lena , Östergren Jan , Hellström Ann
Published: April 2017

Background: Adults born preterm are at risk of developing cardiovascular morbidities. Objective: The aim of this study was to evaluate the relationship between retinopathy of prematurity (ROP) and blood pressure (BP) and salivary cortisol levels during adulthood. Methods: Sixty-nine subjects (mean age 22.6 years) were included. Subjects were adults who were: (a) ex-preterm infants with severe ROP (n = 22), born at gestational age (GA) <30 weeks with a birth weight (BW) <1,000 g, (b) ex-preterm infants with no/mild ROP (n = 21), born at GA <28 weeks with a BW <1,000 g, or (c) full-term controls (n = 26). Anthropometric data, office BP, ambulatory BP, and morning and evening salivary cortisol were analyzed. Results: As adults, ex-preterm infants with severe ROP had on average 7.4 mm Hg higher systolic office BP than those with no/mild ROP (p = 0.019) and controls (p = 0.007). A high cortisol level, tall height, and severe ROP were independent predictors of higher ambulatory systolic BP during adulthood in forward stepwise regression analysis, independent of GA. Conclusion: Our results indicate that preterm infants with severe abnormal retinal vascular development during the neonatal period may be at an increased risk for increased BP during adulthood. We found no differences between those with no/mild ROP as infants and controls with regard to BP data.
Receptor of Advanced Glycation End Products Gene Polymorphism and Primary Open-Angle Glaucoma
Authors: Moschos Marilita M. , Chatziralli Irini , Sioziou Anna , Gazouli Maria
Published: April 2017

Purpose: The purpose of this study was to investigate the potential association between primary open-angle glaucoma and receptor of advanced glycation end products (AGER) polymorphisms in a Greek population. Methods: This is a case-control study of 106 patients with primary open-angle glaucoma and 120 healthy control subjects of Greek origin surveyed for AGER polymorphisms (rs1051993 and rs2070600) and a potential correlation to primary open-angle glaucoma. Results: AGER polymorphisms showed no statistically significant difference between patients with primary open-angle glaucoma and healthy controls. Conclusions: Our study did not find any significant association between AGER polymorphism and primary open-angle glaucoma. Since we cannot reject the possibility that oxidative stress is a crucial factor for the development of primary open-angle glaucoma, further studies may be needed to confirm the importance of the AGER gene in the glaucoma pathogenesis.
Integrative Views of the Heart in Chinese and Western Medicine
Authors: Liu Bin
Published: April 2017

There is a general acknowledgement in almost all civilizations that the heart is the most important organ in the human body. Both Chinese medicine and Western traditional medicine have a long history of heart research, but they have developed different points of view based on the basic cognition. Traditional Chinese medicine is good at summarizing the correspondence and relationship between the heart and exterior things. The physiological functions of the heart are governing blood and vessels, controlling the mind, opening into the tongue, manifesting on the face, and so on, while modern Western medicine does well in exploring the anatomical structure, spacial connection, and micromechanical character of the organ. Chinese medicine and Western medicine have established the diagnosis and management system, respectively, from their own angles. Combining the knowledge of Chinese and Western medicine can take the advantages of either of the two, making it deeper and more comprehensive for studying and treating heart diseases.
Nomenclatural notes on Acanthophyllum (Caryophylleae, Caryophyllaceae)
Authors: PIRANI ATEFEH , RABELER RICHARD K.
Published: April 2017

Acanthophyllum Meyer (1831: 210) in a broad sense comprises 80–90 perennial subshrubby species which are distributed mainly in the Irano-Turanian region (see e.g., Bittrich 1993, Ghaffari 2004, Pirani et al. 2014). According to the phylogenetic study by Pirani et al. (2014), Acanthophyllum s.lat. includes 11 sections. As part of our ongoing taxonomic investigations of Acanthophyllum, corrections to names of five Acanthophyllum sections are made here.
Symptom Clusters and Quality of Life According to the Survivorship Stage in Ovarian Cancer Survivors
Authors: Kim Minhae , Kim Kyunghee , Lim Changwon , Kim Ji-Su
Published: April 2017

This cross-sectional study evaluated a convenience sample comprising 182 ovarian cancer survivors to identify symptom clusters according to the cancer survivorship stage and to determine their effects on quality of life using the European Organization for Research and Treatment of Cancer Quality of Life–C30 and –OV28 questionnaires. Factor and multiple regression analyses were performed to identify symptom clusters according to the cancer survivorship stage and the symptom clusters that affected the quality of life in each cancer survivorship stage, respectively. Participants in the acute, extended, and permanent survival stages accounted for 33%, 36.3%, and 30.7% of subjects, respectively. Overall, the most common symptom cluster was fatigue-diarrhea, and the symptom clusters affecting the quality of life differed according to the cancer survivorship stage. Thus, to improve the quality of life of ovarian cancer survivors, the main symptom clusters of each cancer survivorship stage must be identified, and management strategies for the related symptoms must be designed.
Nativity, Chronic Health Conditions, and Health Behaviors in Filipino Americans
Authors: Bayog Maria L. G. , Waters Catherine M.
Published: April 2017

Introduction: Nearly half of Americans have a chronic health condition related to unhealthful behavior. One in four Americans is an immigrant; yet immigrants’ health has been studied little, particularly among Asian American subpopulations. Methodology: Years lived in United States, hypertension, diabetes, smoking, walking, adiposity, and fruit/vegetable variables in the 2011-2012 California Health Interview Survey were analyzed to examine the influence of nativity on chronic health conditions and health behaviors in 555 adult Filipinos, the second largest Asian American immigrant subpopulation. Results: Recent and long-term immigrant Filipinos had higher odds of having hypertension and diabetes, but lower odds of smoking and overweight/obesity compared with second-generation Filipinos. Discussion: Being born in the United States may be protective against chronic health conditions, but not for healthful behaviors among Filipinos. Chronic disease prevention and health promotion strategies should consider nativity/length of residence, which may be a more consequential health determinant than other immigration and acculturation characteristics.
Sitting-Time and Exercise Predict Depressive Symptoms Among Taiwanese Middle-Aged Adults
Authors: Chang Shu-Hung , Chang Yi-Ya
Published: April 2017

BACKGROUND: Exercise and sitting-time may influence depressive symptoms. OBJECTIVE: The purpose of this study was to examine the relationship between sitting-time, exercise, and depressive symptoms among middle-aged adults. DESIGN: Data from community-based physical examinations between 2013 and 2014 in northern Taiwan were used for this cross-sectional study. We collected demographic data and data on exercise behaviours, sitting-time, and depressive symptoms. RESULTS: A total of 655 participants completed this survey. Of these, 21.2% had depressive symptoms, 33.7% had regular exercise habits, and 24.1% reported a daily average sitting-time of more than 6 hours. Subjects who had regular exercise with lower sitting-time (odds ratio [OR] = 0.49), subjects who had regular exercise with higher sitting-time (OR = 0.55), and subjects who did not have regular exercise with lower sitting-time (OR = 0.34) had less prevalence of depressive symptoms compared to subjects without regular exercise and with higher sitting-time. CONCLUSIONS: Middle-aged adults must exercise regularly and reduce sitting-time to prevent depressive symptoms.
Paroxysmal kinesigenic dyskinesia–like phenotype in multiple sclerosis
Authors: Pop Roxana , Kipfer Stefan
Published: April 2017

In April 2015, a 20-year-old woman with multiple sclerosis (MS) presented with acute onset of repetitive abnormal postures and choreatic movements of the right arm, precipitated by voluntary movements (online video 1 and 2). Brain magnetic resonance imaging (MRI) showed a new active MS lesion involving the basal ganglia on the left side (Figure 1(a)). Intravenous steroid treatment resulted in rapid regression of this paroxysmal kinesigenic dyskinesia (PKD)-like hyperkinetic movement disorder. The patient became asymptomatic within 3 months. PKD is characterized by recurrent uni- or bilateral choreoathetosis and usually represents an autosomal dominant inherited disorder caused by PRRT2 gene mutations. As in the present case, a PKD-like phenotype may be associated with MS relapses in presumably genetic negative cases.
Business models to serve low-income consumers in emerging markets
Authors: Pels Jaqueline , Sheth Jagdish N.
Published: April 2017

Multinational corporations addressing low-income consumers in emerging markets face the challenge of designing business models that provide truly beneficial products and services to the poor. Examples of successful cases are scarce, while the literature review provides little help. Guidelines range from a minimum shift from conventional marketing thinking and practice to radically new approaches involving a wide diversity of non-market actors in a variety of settlements. A classification to help researchers and practitioners is needed.

The article contributes to the literature on business models to serve low-income consumers in emerging markets by proposing conceptual framework, a 2 × 2 matrix. One axis reflects different perceptions of the low-income consumer’s conditions (opportunity/constraint), and the other axis reflects the diverse approaches to developing business models (bottom-up/top-down). The four resulting cells become the article’s suggested alternative business models. The framework allows classifying the extant literature and identifying opportunities for future research. Typologies provide a first step towards theory development as well as offer managers a sound theoretical structure.
Robust fully distributed file caching for delay-tolerant networks: A reward-based incentive mechanism
Authors: Ezzahidi Sidi Ahmed , Sabir Essaid , Koulali Sara , Bouyakhf El-Houssine
Published: April 2017

This article exhibits a reward-based incentive mechanism for file caching in delay-tolerant networks. In delay-tolerant networks, nodes use relay’s store-carry-forward paradigm to reach the final destination. Thereby, relay nodes may store data in their buffer and carry it till an appropriate contact opportunity with destination arises. However, the relays are not always willing to assist data forwarding due to a limited energy or a low storage capacity. Our proposal suggests a reward mechanism to uphold and to sustain cooperation among relay nodes. We model this distributed network interaction as a non-cooperative game. Namely, the source node offers to the relay nodes a positive reward if they accept to cache and to forward a given file successfully to a target destination, whereas the relay nodes may either accept or reject the source deal, depending on the reward attractiveness and on their battery status (their actual energy level). Next, full characterizations of both pure and mixed Nash equilibria are provided. Then, we propose three fully distributed algorithms to ensure convergence to the Nash equilibria (for both pure equilibrium and mixed equilibrium). Finally, we validate our proposal through extensive numerical examples and many learning simulations and draw some conclusions and insightful remarks.
Extracting entity-based information in cyber-physical systems
Authors: Yang Yuchen , Li Lijie , Yin Guisheng
Published: April 2017

This article proposes a framework [Formula: see text] for evaluating entity extraction problem over cyber-physical system data. As known by us, this article is the first work focusing on this problem, which is an important step for identifying entities in cyber-physical system data. Directed by the initial entities, utilizing the relaxation and verification techniques, [Formula: see text] provides a path expression–based solution for entity extraction problem, which has following characteristics. First, using path expressions, [Formula: see text] provides a condensed presentation for entity locations whose size may get very large when scaling up the data size. Second, requiring only one entity example to indicate the interests, using relaxation technique, [Formula: see text] can discover other similar entities automatically. Third, by adjusting the example given to [Formula: see text], users can specify their own interesting entities and control the entities discovered by [Formula: see text]. Besides, utilizing the idea of sharing computations, by extending previous automaton techniques, an efficient implementation of [Formula: see text] is provided. Experimental results are reported, which show that [Formula: see text] can provide an effective and efficient solution to the entity extraction problem.
Differences in swimming ability and its response to starvation among male and femaleGambusia affinis
Authors: Li Jiangtao , Lin Xiaotao , Xu Zhongneng , Sun Jun
Published: April 2017

To explore the differences in the swimming ability and environmental adaptive abilities between male and female Gambusia affinis, we assessed the differences in burst swimming speeds (Uburst), critical swimming speeds (Ucrit) and their related fin areas, and consumption of energy substances after starvation at 0 (control group), 15, 30, 45, and 60 days, respectively. The results showed that the pectoral and caudal fin areas did not differ significantly between male and female G. affinis. However, the dry mass, condition factors, and absolute contents of glycogen, lipids, and proteins were significantly elevated in females in the control group (P<0.05), whereas Uburst and Ucrit were significantly low (P<0.05). After starvation of 60 days, the rate of consumption of lipids was significantly low in the females (P<0.05). Although Uburst and Ucrit decreased linearly with increased duration of starvation, the coefficient of linear equation between Ucrit and starvation time was significantly lower in females than males (P<0.05). These findings indicated that low body mass and condition factors reduce the relative bear load and moving resistance that causes high swimming performance in male G. affinis. High contents of energy substances and low rate of consumption of lipids result in stable Ucrit in females during hunger.
Does air-breathing meet metabolic demands of the juvenile snakehead,Channa argusin multiple conditions
Authors: Li Yongli , Lv Xiao , Zhou Jing , Shi Chenchen , Duan Ting , Luo Yiping
Published: April 2017

The objective of this study was to examine how the respiratory metabolism of the snakehead Channa argus changed when it shifted from breathing water to breathing air and how increased metabolic demands caused by temperature, feeding, and exhaustive exercise affect its survival in air. The results demonstrated that the oxygen consumption rate (MO2) of the snakehead was lower for aerial respiration than aquatic respiration by 12.1%, 24.5%, and 20.4% at 20, 25, and 30°C, respectively. Survival time was significantly shortened with increasing temperature and was negatively correlated with the resting MO2 in air (MO2Air). No obvious feeding metabolic response was observed in the snakeheads fed at 1% and 3% body mass levels while breathing air. The maximum MO2Air of the snakehead after exhaustive exercise was significantly higher than the resting MO2Air of the control group. The results suggest that the snakehead could survive out of water by breathing air for varying lengths of time, depending on ambient temperature and metabolic demand. Additionally, some degree of metabolic depression occurs in the snakehead when breathing air. The metabolic demand associated with exercise in the snakehead, but not that associated with feeding, can be supported by its capacity for breathing air to some extent.
Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice
Authors: Nakagawa Yoshiko , Sakuma Tetsushi , Nishimichi Norihisa , Yokosaki Yasuyuki , Takeo Toru , Nakagata Naomi , Yamamoto Takashi
Published: April 2017

Robust reproductive engineering techniques are required for the efficient and rapid production of genetically modified mice. We have reported the efficient production of genome-edited mice using reproductive engineering techniques, such as ultra-superovulation, in vitro fertilization (IVF) and vitrification/warming of zygotes. We usually use vitrified/warmed fertilized oocytes created by IVF for microinjection because of work efficiency and flexible scheduling. Here, we investigated whether the culture time of zygotes before microinjection influences the efficiency of producing knock-in mice. Knock-in mice were generated using clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) system and single-stranded oligodeoxynucleotide (ssODN) or PITCh (Precise Integration into Target Chromosome) system, a method of integrating a donor vector assisted by microhomology-mediated end-joining. The cryopreserved fertilized oocytes were warmed, cultured for several hours and microinjected at different timings. Microinjection was performed with Cas9 protein, guide RNA(s), and an ssODN or PITCh donor plasmid for the ssODN knock-in and the PITCh knock-in, respectively. Different production efficiencies of knock-in mice were observed by changing the timing of microinjection. Our study provides useful information for the CRISPR-Cas9-based generation of knock-in mice.
Margaret Fisk Taylor’s sacred dance, moving imagination, and kinaesthetic empathy
Authors: Saumaa Hiie
Published: April 2017

In this article, I shed light upon the work of Margaret Fisk Taylor (1908–2004), a pioneer of liturgical dance in the United States. Taylor’s visionary approach to sacred movement and her prolific writings are rarely discussed in dance studies and the full range of her innovative ideas is overlooked in liturgical dance writing. I examine her movement philosophy and her theorization of the dynamics between spirituality, movement and imagination, focusing particularly on her concepts of ‘simple rhythms’ and ‘creative dramatic action’. I demonstrate how Taylor’s use of movement and gesture as a way to imagine, connect to, and empathize with the other adds a new dimension to recent accounts on ‘kinaesthetic empathy’. I suggest that, at the heart, Taylor’s movement philosophy proposes a physicalized form of empathy.
Television formats and the United States: New developments in production and distribution
Authors: Torre Paul
Published: April 2017

This article explores the variety of television formats bought and sold in the US marketplace or exported abroad, and the variety of companies buying and selling as a part of that market. Companies in the television format trade are adjusting to increased competition, and merging, acquiring and strategically allying to become more creative and efficient and to reach new audiences. The author also analyses the recent shift to programming based on repurposed content and how the saturated US television market is impacting demand for television formats. The author contends that the television format industry is experiencing the shakeout and maturity stages of an industry life cycle, as traditional television responds to audience demands for online content, and formatted content is adapted across platforms. The author analyses and evaluates the future prospects in the US marketplace for formatted media content, both domestically and transnationally.
TV formats in anglophone Africa: The hegemonic role of South Africa in the TV format value chain
Authors: Ndlela Martin N.
Published: April 2017

This article examines the television format business in anglophone Africa using a global value chains (GVCs) approach. Examining the format chain value structures and considering the different input and output activities in the global TV-format chain, this article identifies South African media industries as the most dominant players in anglophone Africa. Their dominance is manifested in the different stages of the value chain, from acquisition of format rights to broadcasting of finished programmes to different market segments in the region. This article argues that South Africa’s hegemonic status in the format value chain can be attributed to the formal nature of its creative industries and their configurations within the global/local matrix. South media corporations are embedded into the global media system through their business structures, capital investments, ownership, partnership and strategic alliances. At local level, South African companies have expanded into various African markets. This hegemony is contrasted with countries like Nigeria, who despite being the biggest producer of audio-visual material in Africa, is less active in the global format value chains.
Localization as negotiation: Producing a Korean format in contemporary China
Authors: Zeng Wenna , Sparks Colin
Published: April 2017

This article analyses the localization, as Hurry Up, Brother, of the Korean celebrity reality game show format Running Man by the Chinese broadcaster Zhejiang Satellite TV. Based upon field work involving participant observation and interviews with Chinese and Korean production personnel, the article explores the complex forces involved in realizing the final, highly successful, project. It is argued that localization involves the interplay of complex forces, the outcome of which is a process of negotiation. In particular, the article analyses in detail two major players in this production, Korean format consultants and the Chinese production team. It details the distinctively Korean practice of licensing a format without recourse to a formal specification of production details, and Chinese television professionals’ response to these practices. It is shown that the more informal methods employed result in a transfer of decision-making power from the Korean company to the Chinese company in the course of the production. As a television format show produced in China, the production of Hurry Up, Brother necessarily involved interaction with political forces as well as cultural differences between China and Korea. The article concludes with considering the implications of the findings for our concepts of globalization, localization and hybridization.
The TV format market in Latin America: Trends and opportunities
Authors: Uribe-Jongbloed Enrique , Diez Ethel Pis
Published: April 2017

The Latin American incursion and participation in the trade of audio-visual formats is considerably recent, and has become particularly relevant with the rise of the trade in scripted formats. The region’s expertise in telenovelas has given them an edge in this type of formats, with Argentina leading a conscious strategy to take advantage of the market that opened up following the international success of the Colombian Yo soy Betty, la fea (1999). We present here a summary of the latest developments of the format market in Latin America collected from trade magazine reports and in-depth interviews with leading figures in television production and distribution companies. Our research evinces that cultural proximity and volume of television production output are not necessarily predictors of the regional flow of scripted formats in the region.
R&D expenditure and economic growth: An empirical analysis
Authors: Kaur Manjinder , Singh Lakhwinder
Published: April 2017

Research and Development (R&D) has been of immense value in innovation, raising productivity and increasing economic growth. Nowadays, out of the various factors underlying economic growth, the most efficient are the R&D activities undertaken by the country, which can be most precisely measured by the R&D expenditure incurred by it. The present study is an effort to investigate the link of R&D expenditure with the per-capita Gross Domestic Product (GDP) by taking the data of 23 developing countries covering the period 1991–2010. To this end, after examining the trends and pattern of R&D expenditure in the economies, panel data regression tools such as fixed- and random-effects models have been applied. The respective coefficients of these models – i.e. 0.30 and 0.28 – imply a significant impact of R&D expenditure on economic growth. Further, the increasing coefficient of variation in the economic and technological activities gives the lie to the possibility of convergence across these economies over the period of time.
Estudo clínico comparativo entre reparo após sutura convencional e incisão à laser de dióxido de carbono (co2) com diferentes potências
Authors: Raldi Fernando Vagner , Niccoli-Filho Walter , Prakki Purnima
Published: April 2017

No presente estudo analisamos clinicamente as diferenças de respostas entre incisão à bisturi e à laser de CO2 na reparação tecidual, em pele de ratos. No grupo controle a incisão foi realizada com bisturi convencional seguida de sutura simples. Nos grupos tratados, a incisão foi realizada com laser CO2 variando-se as potências utilizadas (5, 10, 15 e 20W respectivamente). Os animais foram fotografados imediatamente após a cirurgia e com 3, 7, 14 e 21 dias. Notamos que nos grupos tratados com laser de CO2 houve ausência de sangramento, proporcionando melhor visualização do campo operatório e menor intensidade de inflamação e/ou edema pós operatório. Nas potências de 15 e 20W ocorreram áreas de carbonização ao longo das regiões incisadas, bastante evidentes, provocando um retardo na reparação, quando comparadas à incisão convencional. Já com as potências de 5 e 10W, a reparação teve um padrão similar ao do grupo controle.
Estudo in vitro da porosidade da resina acrílica ativada termicamente através de ciclo longo e por energia de microondas
Authors: Júnior Tarcísio José de Arruda Paes , Marchini Leonardo , Kimpara Estevão Tomomitsu
Published: April 2017

O objetivo deste trabalho foi investigar a ocorrência de porosidades em corpos de prova de resina acrílica ativada termicamente (RAAT), em função das variáveis ciclo de polimerização (banho de água quente convencional e por energia de microondas), fase da prensagem da resina (pegajosa, plástica ou borrachóide) e tempo decorrido da prensagem ao início do ciclo de ativação. A metodologia empregada consistiu da confecção de cubos de cera 7 de 2 cm de aresta num total de 36 cubos, que foram divididos em dois grupos de 18, sendo um grupo destinado á acrilização pela técnica convencional em ciclo longo, utilizando-se da resina incolor de polimerização térmica marca CLÁSSICO e o outro em microondas, no ciclo proposto pelo fabricante da resina (ONDA-CRYL, marca CLÁSSICO). Cada grupo foi ainda subdividido em dois grupos de nove cubos, sendo um levado imediatamente para a polimerização após a prensagem da resina e o outro, aguardando-se 24 horas pós prensagem para então polimerizar. As resinas foram prensadas em três fases diferentes (pegajosa, plástica e borrachóide) sendo que em cada mufla foram incluídos três cubos. Os resultados foram obtidos por observação visual da quantidade de porosidade em cada cubo, por quatro observadores que atribuíram escores. Os dados foram compilados e submetidos à análise estatística não paramétrica. Assim sendo pode-se concluir que para o volume de material considerado na pesquisa, os corpos de prova que apresentaram melhores resultados foram aqueles obtidos em polimerização convencional nas fases plástica e borrachóide com período de descanso de 24 horas.
Evaluation of cell culture cytotoxicity of 5 root canal sealers: release of hydrogen peroxide
Authors: Leonardo Renato de Toledo , Consolaro Alberto , Carlos Iracilda Zepone , Leonardo Mário Roberto , Palo Renato Miotto
Published: April 2017

A Citotoxicidade de quatro cimentos obturadores à base de hidróxido de cálcio (Sealapex, CRCS, Apexit e Sealer26) e um cimento à base de óxido de zinco e eugenol (Fill Canal) foi avaliada em cultura de macrófagos retirado de peritônio de rato para liberação de peróxido de hidrogênio. A menor citotoxicidade foi para o cimento CRCS, seguida em ordem crescente de citotoxicidade pelo Sealapex, Apexit, Fill Canall e Sealer 26.
Materiais ósseo-indutores para o complexo dentino pulpar
Authors: Torres Carlos Rocha Gomes , Carvalho João Candido de , Valera Marcia Carneiro , Araújo Maria Amélia Máximo de
Published: April 2017

Mediante exposições pulpares, várias substâncias tem sido utilizadas visando estimular a reparação tecidual. A mais tradicionalmente empregada é o Ca(OH)2, que apresenta resultados satisfatórios, embora não possa ser considerado biocompatível. Diversos pesquisadores vem estudando materiais alternativos, que aliem os efeitos positivos do Ca(OH)2 a uma melhor biocompatibilidade. Dentre eles podemos citar as cerâmicas bioativas como a hidroxiapatita e o a-TCP. Por outro lado, estudos através de biologia molecular permitiram a descoberta de uma nova família de proteínas que regulam os processos de formação de tecido duro. Em estudos laboratoriais, estas proteínas tem exibido resultados bastante promissores. Este artigo têm por objetivo fazer uma revisão sobre os principais aspectos envolvidos no processo de reparação pulpar, assim como sobre os materiais que vem sendo estudados como agentes de capeamento.
Plano de ensino de uma disciplina de “urgências e emergências em Odontologia"
Authors: Marchini Leonardo , Patrocínio Mônica César do , Rode Sigmar de Mello
Published: April 2017

O presente trabalho tem como objetivo apresentar um plano de ensino de uma disciplina de “Urgências e Emergências em Odontologia”, de modo a chamar a atenção para a necessidade de possibilitar ao aluno o atendimento de pacientes portadores de quadros agudos de dor, em serviço de pronto-socorro, e discutir os tópicos constantes deste planejamento (carga horária, objetivos, conteúdo, recursos de ensino, estratégias de aprendizagem e de avaliação, e avaliação da disciplina).
Joint vibration analysis in mandibluar movements in asymptomatic volunteers
Authors: Olivieri Karina Andrea Novaes , Garcia Alicio Rosalino
Published: April 2017

O ruído articular é um dos sinais de desordens temporomandibulares. Sua identificação é importante para estabelecer o diagnóstico de mudanças patológicas que ocorrem na articulação temporomandibular (ATM). Como há pouco estudos relativos a vibrações em indivíduos assintomáticos, o objetivo dessa investigação foi avaliar as vibrações durante os movimentos de abertura e fechamento mandibular. Nesse estudo, 29 voluntários assintomáticos foram submetidos ao exame clínico e ao teste de Fonseca6. Depois do exame inicial, os voluntários foram submetidos à avaliação através da eletrovibratografia (SonoPAK/I). O grupo controle foi estabelecido com cinco indivíduos selecionados nos quais foram posicionados os transdutores para gravar a vibração da ATM sem movimento mandibular. Outro grupo de gravações foi obtido com os transdutores colocados dentro de uma caixa de papelão e em meio ambiente com o mínimo de ruídos possível. Os resultados foram tabulados e notou-se que os valores aumentavam próximo ao final da abertura e final do fechamento mandibular. As conclusões foram: a) as vibrações na ATM estão presente em indivíduos assintomáticos; b) A energia de vibração da ATM é maior quando a mandíbula está próxima do final da abertura e final do fechamento mandibular; c)A energia vibratória sem movimento mandibular é menor e permanece estável durante as posições analisadas; d) O pico de freqüência esteve situado entre 56 e 99 Hertz. As freqüências analisadas neste estudo não foram detectadas pelo ouvido humano e confirma que o líquido sinovial foi realmente gravado.
Prevalence of Actinobacillus actinomycetemcomitans in moderate and advanced periodontitis
Authors: Cortelli Sheila Cavalca , Cortelli José Roberto , Nascimento Luiz Fernando Costa , Jorge Antonio Olavo Cardoso
Published: April 2017

Actinobacillus actinomycetemcomitans é um bastonete Gram negativo, pequeno, não formador de esporo, imóvel, anaeróbio facultativo. Esta bactéria tem sido fortemente associada na etiologia da peridontite juvenil localizada, podendo também ser isolada em outras formas de doença periodontal como a periodontite do adulto. O objetivo do presente estudo foi determinar a prevalência de Actinobacillus actinomycetemcomitans em indivíduos diagnosticados com periodontite moderada e avançada, que se apresentaram para tratamento clínico geral na clínica odontológica da Universidade de Taubaté, São Paulo. A população estudada compreendeu 87 indivíduos, trinta homens e 57 mulheres, entre 25 e 72 anos de idade (média de idade de 40,1± 9,8). Através das medidas de profundidade de sondagem (PS), foram determinados dois dentes teste (>PS) e dois dentes controle (<PS) do mesmo indivíduo. A partir destes quatro dentes selecionados, amostras de placa bacteriana subgengival foram obtidas, de todos os indivíduos examinados, colocando-se três cones de papel esterilizados subgengivalmente (por dente) e mantidos em posição por 10 segundos. Os cones de papel foram então colocados em tubos contendo solução de Ringer e processados separadamente por dente. Os resultados mostraram que 17 (!9,3%) dos indivíduos apresentaram amostras positivas de Actinobacillus actinomycetemcomitans. Esta bactéria foi distribuída entre seis e 11 individuos, respectivamente apresentando periodontite moderada e avançada. Dos 348 dentes examinados (174 dentes teste e 174 dentes controle), 16 dentes teste e quatro dentes controle apresentaram amostras positivas de Actinobacillus actinomycetemcomitans. Os resultados observados no presente estudo evidenciam uma maior prevalência de Actinobacillus actinomycetemcomitans nos indivíduos com lesões periodontais avançadas.
Comparação entre o diagnóstico clínico e radiográfico da cárie dental
Authors: Amore Ricardo , Anido Andréa Anido , Moraes Luiz Cesar de , Moraes Mari Eli Leonelli de
Published: April 2017

A ciência vem evoluindo muito nas últimas décadas, principalmente em relação à conscientização da importância do diagnóstico precoce das doenças. Na Odontologia, o diagnóstico precoce das lesões de cárie tornou-se procedimento fundamental para a formulação do plano de tratamento que vise a prevenção, o conservadorismo e a promoção da saúde como um todo. Atualmente, vários métodos de diagnóstico têm sido utilizados: exame clínico, radiográfico, afastamento mecânico dos dentes, transiluminação por fibra óptica, detector elétrico de cáries, corantes e digitalização de radiografias. O objetivo neste trabalho foi revisar a literatura sobre os métodos clínicos e radiográficos de diagnóstico da doença cárie.
Analysis of implant/abutment marginal fitting
Authors: Guimarães Mariana Pimentel , Nishioka Renato Sussumu , Bottino Marco Antonio
Published: April 2017

O índice de sucesso dos implantes osseointegrados gira em torno de 90%. Apesar de se conhecer bem os mecanismos da osseointegração ainda ocorrem falhas nos sistemas de implantes. Pesquisas recentes atribuem essas falhas, principalmente, à reabilitação protética do paciente. O desajuste entre a base do implante e o pilar protético e a falta de adaptação passiva entre a prótese e os pilares podem levar a fraturas tanto dos componentes protéticos quanto do parafuso do pilar ou do próprio implante; pode também levar à distribuição inadequada das forças ao osso de suporte, acúmulo de bactérias e até mesmo à perda da osseointegração. A natureza da perda ou deslocamento das próteses é complexa, envolvendo fatores como: material do pilar protético, tipo de encaixe, grau de conicidade, precisão de usinagem dos componentes do sistema, fadiga, penetração de fluidos bucais, variedades de mastigação, dentre outros. Considerando a importância de uma longevidade maior dos implantes osseointegrados e da necessidade de se obter a melhor adaptação possível entre base do implante e pilar protético, esse trabalho realizou uma revisão da literatura sobre a importância do perfeito ajuste entre esses dois componentes, suas implicações biomecânicas, funcionais, biológicas e clínicas e ainda, levantar os diferentes métodos para estudo dessa interface de união.
Abordagem imunológica da cárie dental
Authors: Souza Gleicy Fátima Medeiros de , Andrade Emanuel Sávio de Souza , Miranda João Luiz de , Alves Ruthinéia Diógenes , Pinto Leão Pereira , Almeida Dulce
Published: April 2017

A descoberta de um sistema de defesa mucoso imunoenzimático, aliado aos avanços da imunologia demonstram a necessidade do conhecimento dos seus conceitos e suas possíveis interrelações frente à instalação e progressão do processo cariogênico. Diante deste fato, o presente trabalho se propõe realizar uma revisão de literatura, a cerca destes conhecimentos, buscando verificar a sua relação com os microorganismos e o desenvolvimento da doença cárie.
A comparative study of flexural strength using two composite resins fiber reinforced
Authors: Bottino Marco Antonio , Quintas Adriana Ferreira , Bondioli Ilda Ribeiro
Published: April 2017

A finalidade deste estudo foi de avaliar as propriedades mecânicas de duas resinas compostas Charisma (Heraeus Kulzer, Alemanha) e Permalute (Ultradent Products Inc.) e verificar a influência da adição de uma fibra (Ribbond, Ribbond Inc.) na resistência à flexão das duas resinas. Foram preparados 52corpos-de-prova num dispositivo de aço inoxidável com base retangular, sobre a qual é parafusada uma placa também em aço inoxidável com nove espaços usinados medindo 15mm de comprimento, 2mm de largura e 1mm de espessura, sobre os quais se aplicou as resinas compostas associadas ou não a fibras. Os corpos-de-prova foram divididos em quatro grupos (n=13), sendo o Grupo I somente de resina composta Charisma; Grupo II resina Charisma+Ribbond; Grupo III somente de resina Permalute e Grupo IV de resina Permalute+Ribbond. As amostras foram submetidas ao ensaio de compressão de três pontos para verificar a resistência flexural em um aparelho MTS-810 até à ruptura das mesmas e então avaliadas sob microscopia eletrônica de varredura. Os dados foram submetidos aos testes paramétricos 1-way ANOVA, análise de variância e de Comparação Múltipla de Tukey (5%), após o teste de homogeneidade de variância, teste de Levene, sob nível de significância de 5%. As amostras do Grupo I obtiveram média de 164,71 MPa (d.p. = 21,49%); para o Grupo II, a média de ruptura foi de 292,28 MPa (d.p. = 34,24%); para o Grupo III a média foi de 106,50 MPa (d.p. = 24,02%) e para o Grupo IV os valores médios foram 61,70 MPa (d.p. = 24,92%). Os resultados demonstram que a adição de fibras entrelaçadas aumentou consideravelmente a resistência à flexão, sendo melhor para Charisma+Ribbond do que Permalute+Ribbond. Entretanto, pela análise da região fraturada empregando-se o M.E.V., concluimos que não ocorreu reação química entre as resinas compostas e as fibras, embora não apresente completa separação entre a matriz e as fibras.
Atrofia e regeneração da glândula parótida após ligadura do ducto excretor: estudo histológico e histoquímico em ratos
Authors: Siqueira Tatiana Varas , Colombo Carlos Eduardo Dias , Balducci Ivan , Carvalho Yasmin Rodarte
Published: April 2017

O objetivo deste trabalho foi estudar a atrofia unilateral da glândula parótida de ratos, após a ligadura do ducto excretor,e a regeneração glandular, através de ligadura ductal seguida pela remoção da obstrução após sete dias, analisando as alterações morfológicas glandulares e o potencial proliferativo dos ductos intercalares. Análise morfológica foi também realizada na parótida contralateral. Os ratos foram sacrificados e suas glândulas foram processadas e submetidas às colorações histológicas (HE e PAS) e histoquímica (AgNOR). Durante a atrofia glandular, houve degeneração e redução do parênquima, assim como inflamação e fibrose. Durante a regeneração glandular, houve o restabelecimento do parênquima e redução da inflamação e da fibrose. Nas glândulas contralaterais, houve desorganização e degeneração teciduais. Não foi observada alteração do potencial proliferativo dos ductos intercalares durante o experimento.
Avaliação da infiltração marginal após clareamento dental e restauração com resina composta, variando o sistema adesivo
Authors: Fayad Maria Victória Lauris , Anbinder Ana Lia , Marques Alexandre Perez , Amore Ricardo , Valera Márcia Carneiro , Araújo Maria Amélia Máximo de
Published: April 2017

O objetivo deste estudo foi avaliar a infiltração marginal em restaurações com resina composta, variando o sistema adesivo, após técnica de clareamento dental. Foram utilizados 15 premolares humanos, nos quais foram confeccionadas, nas superfícies vestibulares e linguais, cavidades de classe V. O agente clareador, perborato de sódio acrescido de água, foi aplicado em todas as cavidades, que posteriormente foram seladas com cimento de ionômero de vidro. A mistura clareadora foi trocada duas vezes, em intervalos de quatro dias e após o clareamento, as cavidades foram neutralizadas com pasta à base de hidróxido de cálcio. As restaurações foram confeccionadas com resina composta, variando-se o sistema adesivo: nas cavidades vestibulares realizou-se condicionamento com ácido fosfórico 37% seguido da aplicação de sistema adesivo convencional, e nas cavidades linguais, utilizou-se sistema adesivo autocondicionante. Os dentes foram impermeabilizados (exceto 1mm das margens das restaurações), imersos em Rodamina B, e preparados para observação em estereomicroscópio. As amostras foram classificadas de acordo com escores de infiltração marginal e os dados submetidos ao teste de Mann Whitney, a 5% de significância. Verificou-se não existir diferenças estatisticamente significantes entre as duas condições experimentais avaliadas. Concluiu-se que o tipo de sistema adesivo (convencional ou autocondicionante) não interfere no selamento das restaurações após clareamento dental.
Análise comparativa das distâncias mésio-distal e gêngivo-incisal dos incisivos centrais superiores com a régua trubyte tooth indicator
Authors: Freitas Karina Buainain de , Pinto João Henrique Nogueira , Miraglia Simone Soares
Published: April 2017

Com o objetivo de auxiliar na etapa de seleção de dentes artificiais para próteses totais, propôs - se verificar a relação existente entre as distâncias mésio - distal (MD) e gêngivo – incisal (GI) dos incisivos centrais superiores, com as medidas obtidas através da régua trubyte tooth indicator da Dentisply. Foram avaliados 100 individuos com ausência de assimetria facial e apresentando os 06 dentes anteriores hígidos. Os resultados demonstraram que 100 % dos pacientes avaliados apresentaram uma diferença estatisticamente significante entre as medidas relacionadas promovendo uma diferença, do paciente para a régua, de - 0,49 para a distância MD e de 0,69 para a GI, o que possibilitou concluirmos que a utilização da régua trubyte tooth indicator para a seleção de dentes anteriores, resultaria em próteses com dentes mais longos e mais estreitos.
Avaliação eletromiográfica e eletrovibratográfica antes e após o tratamento da desordem temporomandibular
Authors: Turcio Karina H. L. , Garcia Alicio R. , Derogis Alessandra R. , Zuim Paulo R. J.
Published: April 2017

A patologia muscular pode ser conseqüência de um efeito coprotetor que afeta a atividade elétrica do músculo com a presença ou não de ruídos articulares. Para verificar essas alterações foram tratados cinco pacientes com comprometimento muscular e com desordens inflamatórias na ATM. Através da eletrovibratografia verificou-se que os ruídos articulares diminuíram sua intensidade vibratória com o tratamento. Enquanto que a eletromiografia mostrou que o músculo masseter aumentou sua atividade elétrica durante a mastigação e apertamento dental e o temporal diminuiu, em pelo menos um dos lados do paciente. Contudo as diferenças encontradas não são estatisticamente significantes.