bluuebunny/crossref_metadata_2025 huggingface dataset:
“A Pencil for your Thoughts”: Participatory Drawing as a Visual Research Method with Children and Youth
Authors: Literat Ioana
Published: July 2017

This article explores the use of participatory drawing as a non-mechanical visual research method in qualitative research with children and youth. Because of its co-constructed and playful nature, as well as its lack of dependence on linguistic proficiency, participatory drawing emerges as a highly efficient and ethically sound research strategy that is particularly suited for work with children and young people across a variety of cultural contexts. The analysis of drawn images, complemented by a subsequent discussion of these drawings in the context of their production, has the potential of revealing a more nuanced depiction of concepts, emotions, and information in an expressive, empowering, and personally relevant manner. As a review of the participatory drawing methodology, this article draws on several examples in order to highlight the inherent affordances of the visual mode and discuss the benefits and limitations of using this strategy in research with children and youth.
‘Moments and opportunities’
Authors: Grainge Paul
Published: July 2017

This article examines the promotion of the BBC’s online streaming and download service, iPlayer, as it has been presented to audiences through broadcast television. Analysing transitions in the BBC’s representation of iPlayer, it considers the promotional imagination of the service during the 2010s, a period when the Corporation was striving to communicate its digital identity and broaden iPlayer within mainstream use. Through industrial–textual analysis, the essay considers the paratextual function of iPlayer interstitials, and the relation of on-air promos to the Corporation’s internal strategy for the service in moving ‘beyond PC, beyond catch-up, beyond the early-adopter’.
Watching CSI: A study of British audiences watching Channel 5 and 5 USA
Authors: Weissmann Elke
Published: July 2017

Despite consumption patterns gradually changing, the notion of flow remains a key concept drawn on by scholars to understand television. As a concept, ‘flow’ is connected to an understanding of the difference of television from other media as far as the viewing experience is concerned: rather than a single film, audiences encounter a number of small units that are combined in the process of audiences’ sense making. In this understanding, ephemera become as important as programmes as they interlink to create a meaningful whole. On the other hand, John Ellis argues that the more typical form for television is actually the segment which contains a separate meaning within itself. Using an audience ethnography, this article argues that in the experience of audiences, the concepts of flow and segmentation are both in evidence. Rather than seeing them as opposing, therefore, they must be understood as complementary in order to fully account for audiences’ experiences and sense making of television.
A cloud-based location assignment system for packaged food allocation in e-fulfillment warehouse
Authors: Hui Yasmin YY , Choy KL , Ho GTS , Leung KH , Lam HY
Published: July 2017

E-retailing is the delivery of products and services over the Internet, and it has been growing rapidly in recent years. Logistics services in the related warehouses have to be enhanced accordingly in order to handle the huge amount of e-orders in a shorter timeframe. Moreover, since the e-retailing of packaged food has been getting popular, these warehouses inevitably have to handle food products requiring special care, including temperature, humidity and insolation control, and expiry date management. Consequently, suitable storage guidelines have to be formulated for these warehouses to cope with their more demanding daily operations. A cloud-based location assignment system (CLAS) is thus proposed in this article, which provides timely and comprehensive solutions to the storage location assignment problem for warehouse operators. CLAS applies (i) cloud-based infrastructure for enhancing the agility of the proposed system, (ii) fuzzy association rule mining for predicting the potential storage time of various types of packaged food, and (iii) fuzzy logic and association rule mining for offering the most preferred storage locations of various products. A prototype of the CLAS is tested in a warehouse which involves packaged food handling. The test results show that the operational efficiency measured in terms of storage assignment decision-making time and order-picking time and the quality of the storage assignment solutions measured in terms of product disposal rate and product return/exchange rate have been improved in the case company.
The Variability of Estimated Glomerular Filtration Rate Decline in Alport Syndrome
Authors: Langsford David , Tang Mila , Djurdjev Ognjenka , Er Lee , Levin Adeera
Published: July 2017

Background:

A progressive trajectory toward renal failure is common in patients with Alport syndrome. Genotype-phenotype correlations have been well described; however, the natural history of the trajectory toward renal failure is not well described.

Objective:

The objective of this study is to describe the natural history of renal function decline in a cohort of Alport syndrome patients.

Design:

Retrospective observational cohort study.

Setting:

British Columbia, Canada, chronic renal disease registry 1995-2012.

Patients:

37 biopsy proven Alport syndrome or hematuria with family history of Alport syndrome.

Measurements:

Serial estimated glomerular filtration rate (eGFR) Trajectory of renal decline described graphically by fitting a cubic smoothing spline to patient’s eGFR measures. Various time points within a trajectory were indexed, randomly sampled, and followed for 2 years to estimate portion of progressors (>5 mL/min/1.73 m2 /y decline), stable state (0-2 mL/min/1.73 m2 /y decline), and regressors (>2 mL/min/1.73 m2 /y incline).

Methods:

In this retrospective observational cohort study, participants were identified through a chronic renal disease registry in British Columbia, Canada, from 1995 to 2012. Inclusion criteria were biopsy proven or hematuria with a family history of Alport syndrome. Individual patients and family group members were studied. Trajectory of renal decline described graphically by fitting a cubic smoothing spline to patient’s serial estimated glomerular filtration rate (eGFR) measures. Various time points within a trajectory were indexed, randomly sampled, and followed for 2 years to estimate portion of progressors (>5 mL/min/1.73 m2/y decline), stable state (0-2 mL/min/1.73 m2/y decline), and regressors (>2 mL/min/1.73 m2/y incline).

Limitations:

Histological or genetic evidence of Alport syndrome is not available in all patients.

Results:

Median follow-up time was 48.2 months of 37 patients (78% male), with a median age of 36 (interquartile range [IQR], 18-47) and a median age of renal replacement therapy commencement (n = 23) of 38 (IQR = 20-52). Renal function changes were found to be heterogeneous overall, intra-individual and within families. Portion of progressors in eGFR 45-60 mL/min/1.73 m2 was 73.7% (SD, 10.3), whereas 23.6% (SD, 11.0) remained stable. Within eGFR 30-45 mL/min/1.73 m2, 45.6% (SD, 7.0) were progressors, whereas 53.4% (SD, 7.4) remained stable. A large portion of eGFR 15-30 mL/min/1.73 m2 patients were stable (54.8%; SD, 8.4), whereas 25.7% (SD, 7.1) progressed and 19.5% (SD, 5.6) regressed.

Conclusions:

The renal decline in Alport syndrome patients is heterogeneous which has implications for designing clinical trials of interventions.
Do Major League Baseball Team Physicians Harvest the Semitendinosus From the Drive Leg or Landing Leg When Performing Ulnar Collateral Ligament Reconstruction on Elite Baseball Pitchers?
Authors: Erickson Brandon J. , Chalmers Peter N. , Dugas Jeffrey R. , Bach Bernard R. , Nicholson Gregory P. , Verma Nikhil N. , Ahmad Christopher S. , Romeo Anthony A.
Published: July 2017

Background:

Hamstring autograft is a common graft choice when performing ulnar collateral ligament reconstruction (UCLR).

Purpose/Hypothesis:

The purpose of this study was to survey Major League Baseball (MLB) team physicians and determine whether these physicians harvest the hamstring (semitendinosus or gracilis) from the drive leg (ipsilateral to surgical site) or landing leg (contralateral to surgical site) when performing UCLR on elite-level pitchers. The hypothesis was that the majority of surgeons harvest the hamstring from the drive leg when performing a UCLR.

Study Design:

Descriptive epidemiology study.

Methods:

Overall, 52 MLB team orthopaedic surgeons were sent the 5-question online survey. The survey assessed surgeon UCLR volume, surgical technique, which leg the hamstring graft was harvested from, the reasoning for choosing that particular leg, and whether the surgeon would change their practice if evidence showed the hamstring from one of the legs was more important than the other. The survey was sent out 5 separate times to maximize the response rate.

Results:

Forty (77%) MLB team physicians completed the survey. The largest number of surgeons (n = 16; 40%) performed between 5 and 14 UCLRs annually, while 6 (15%) performed more than 50 UCLRs annually. Most surgeons (n = 23; 57.5%) used the docking technique. Significantly more surgeons harvested the hamstring from the landing leg (n = 29; 72.5%) compared with the drive leg (n = 11; 27.5%) ( P = .007). More surgeons cited the reason for their choice of leg as a belief that the hamstring they harvested plays less of a role in the ability of a pitcher to generate a forceful pitch (n = 25; 62.5%) than for logistical reasons in the operating room (n = 15; 37.5%); this difference was not statistically significant. Significantly more surgeons would change their practice (n = 35; 87.5%) if evidence showed the hamstrings from a specific (drive or landing) leg to be more active in the throwing motion compared with those who would not ( P < .001).

Conclusion:

When performing a UCLR using hamstring autograft, the majority of MLB team physicians harvest the hamstring from the landing leg as opposed to the drive leg, as they believe the hamstring from the landing leg plays less of a role in generating a forceful pitch than that from the drive leg.
Draft genome sequences of strains Salinicola socius SMB35T, Salinicola sp. MH3R3–1 and Chromohalobacter sp. SMB17 from the Verkhnekamsk potash mining region of Russia
Authors: Olsson Björn E. , Korsakova Ekaterina S. , Anan’ina Lyudmila N. , Pyankova Anna A. , Mavrodi Olga V. , Plotnikova Elena G. , Mavrodi Dmitri V.
Published: July 2017

Halomonads are moderately halophilic bacteria that are studied as models of prokaryotic osmoadaptation and sources of enzymes and chemicals for biotechnological applications. Despite the progress in understanding the diversity of these organisms, our ability to explain ecological, metabolic, and biochemical traits of halomonads at the genomic sequence level remains limited. This study addresses this gap by presenting draft genomes of Salinicola socius SMB35T, Salinicola sp. MH3R3–1 and Chromohalobacter sp. SMB17, which were isolated from potash mine tailings in the Verkhnekamsk salt deposit area of Russia. The analysis of these genomes confirmed the importance of ectoines and quaternary amines to the capacity of halomonads to tolerate osmotic stress and adapt to hypersaline environments. The study also revealed that Chromohalobacter and Salinicola share 75–90% of the predicted proteome, but also harbor a set of genus-specific genes, which in Salinicola amounted to approximately 0.5 Mbp. These genus-specific genome segments may contribute to the phenotypic diversity of the Halomonadaceae and the ability of these organisms to adapt to changing environmental conditions and colonize new ecological niches.
Supporting effective school readiness in all children
Authors: Peckham Kathryn
Published: July 2017

With a well-publicised effect on future success, ‘school readiness’ is a term often used, but seldom fully understood. If we are to help children begin school with the best chance of success, preconceived notions of their abilities in the run-up to the school gates needs challenging. With growing research to support the need for rich, diverse experiences throughout children's early years, this article embraces a new way of thinking, adjusting attention from the media-focused, yet factually lacking concepts of the child considered ‘ready for learning’ to one that celebrates the wide-ranging, holistic abilities of all children. Working face-to-face with families, health visitors are ideally placed to aid their understanding of preparations for effective school learning, celebrating their vital role in their child's early years in ways accessible to all.
Newborn Behavioural Observations System: Benefits and opportunities for integration into practice
Authors: Hawthorne Joanna , Nicolau Susana
Published: July 2017

The Newborn Behavioural Observations (NBO) system is a relationship-building tool highlighting baby behaviours from birth to 3 months old. The aim of this survey was to evaluate the use of the NBO by practitioners (n=133) approximately 7 months after completion of the NBO training course. The results show that most practitioners are focusing on specific family needs and babies' behavioural states (using parts of the NBO), and using it as a whole routinely and/or its principles (based on understanding baby development and parenting). Practitioners are particularly keen to focus on items related to baby's social/interactive skills and crying/consolability and 84% are using the NBO with both fathers and mothers. Practitioners reported that the most valued benefit of the NBO was an enhancement of practice and knowledge about baby behaviour. Opportunities for improvement were also identified, such as a need for practice to become proficient using the tool, support on implementation and continued professional development.
Suplementos nutricionales en el desarrollo psicomotor y cognitivo en la infancia: Una revisión de la literatura
Authors: Soto-Salazar Carolina , Rueda-Rodríguez María Camila , De Castro Melissa , Castañeda-Cardona Camilo , Roselli Diego
Published: July 2017

Introducción: en los últimos años, la malnutrición y su impacto en el desarrollo cognitivo y psicomotor de las personas ha cobrado interés, así como el uso de suplementos nutricionales en la dieta regular con el fin de evitar o disminuir los efectos negativos de una alimentación inadecuada en el desarrollo global de una persona. Dado que se conocen los requerimientos de elementos como el ácido docosahexaenoico (DHA) durante el desarrollo neurológico en las etapas más tempranas de la vida, resulta de gran importancia evaluar el alcance de la suplementación de estos componentes y su relación con la cognición en población

pediátrica.

Métodos: se realizó una revisión de la literatura en las bases de datos Embase y Pubmed teniendo en cuenta estudios que relacionaran la suplementación nutricional con ácidos grasos, hierro y zinc y las funciones cognitivas en niños.

Resultados: se encontró evidencia que sugiere que los suplementos nutricionales con ácidos grasos poliinsaturados (DHA y omega 3), hierro y zinc mejoran el desarrollo cognitivo de los niños.

Conclusiones:Los suplementos nutricionales con Omega 3, DHA, hierro y zinc podrían proporcionar beneficios en el desarrollo cognitivo, principalmente en lactantes y escolares sin efectos adversos de importancia.
Editorial
Authors: Arroyo Arq. Julio
Published: July 2017

Editorial
Comportamiento del mercado inmobiliario entorno a un gran proyecto urbano
Authors: Barenboim Dra. Arq. Cintia Ariana
Published: July 2017

La investigación se centra en el impacto económico que genero el gran proyecto urbano Puerto Norte en sus barrios aledaños de Refinería y Pichincha en la ciudad de Rosario.

El objetivo radica entonces en analizar los procesos de producción y valorización de estos dos barrios históricos, que contaban con terrenos vacantes y poco valorizados. Para ello se describen los lotes y casas antiguas que se ofertan, el incremento de la demanda, los nuevos agentes locales involucrados, los tipos de sub-mercados y los precios de terrenos e inmuebles, expresando las distintas modalidades de especulación.

Los principales resultados evidencian que Pichincha tuvo un desarrollo edilicio anterior al inicio de sus obras y de mayor envergadura mientras que Refinería sufre un impacto menor pero directamente vinculado con Puerto Norte. La mayor valorización se establece en las avenidas, relacionado directamente con la localización y el cambio normativo.
Museo de Arte de Teshima
Authors: Parodi Rebella Dr. Arq. Aníbal
Published: July 2017

El presente artículo de reflexión desarrolla, con una mirada pautada fuertemente por la vivencia directa del espacio y la intención de generar un discurso textual y visual equilibrado, una profundización en las lógicas proyectuales imbricadas en una obra singular: el Museo de Arte de Teshima. Se trata de una obra iniciática, sin referenicas previas, que encuentra su identidad en el balance entre arquitectura y arte y entre arte y naturaleza, y se despliega en un espacio conceptual en el cual las repuestas formales, expresivas, funcionales y técnicas se entrelazan e imbrican hasta fundirse. La reflexión se desarrolla a partir de dos variables principales: la experiencia peceptiva y la manipulación de la escala, y plantea una criba de atributos de proyecto que incluye entre otros: objetualidad, pregnancia, abstracción, figuración y analogía, experiencia perceptiva y háptica, movimiento en el espacio, escala de observación, y dimensión temporal. El trabajo surge como una revisión, complemento y ulterior desarrollo de una investigación previa centrada en el estudio del rol un atributo fundamental del proceso de proyecto como la escala.
Das (unheimliche und) unsichere Tal der Assistenz und Automation – Beschreibung und Absicherungsmöglichkeiten
Authors: Flemisch Frank Ole , Altendorf Eugen , Canpolat Yigiterkut , Weßel Gina , Baltzer Marcel , Lopez Daniel , Herzberger Nicolas Daniel , Voß Gudrun Mechthild Irmgard , Schwalm Maximilian
Published: July 2017

Fortschritte in der Automatisierungstechnik ermöglichen es technischen Systemen immer mehr Aufgaben zu
übernehmen. Für die Gestaltung der Interaktion und Kooperation von Mensch und Maschine ist die Einschätzung
des Menschen bzgl. der Fähigkeiten der Maschine sicherheitsrelevant. Das Uncanny Valley der Robotik
beschreibt, wie Roboter mit hoher, aber nicht perfekter Menschenähnlichkeit als unheimlich wahrgenommen
werden. Bestehende Studien, z. B. für Luft- und Bodenfahrzeuge, deuten an, dass es einen ähnlichen Zusammenhang
zwischen Automationsgrad und Sicherheit geben könnte, da sich zwischen gut funktionierenden teil- und
hochautomatisierten Modi ein unsicheres Tal bildet, in welcher die Sicherheit des Systems stark reduziert ist. Es werden
Gestaltungsoptionen beschrieben, um diesen Bereich abzusichern.
Assistenz- und Autonomiefunktionen zur Entlastung des Fahrers in Offroad-Szenarien
Authors: Lüttel Thorsten , Ebert Felix , Faßbender Dennis , Fries Carsten , Heinrich Benjamin C. , Jaspers Hanno , Kallwies Jan , Naujoks Benjamin , Wünsche Hans-Joachim
Published: July 2017

Im Onroad-Bereich sind viele Fahrerassistenzsysteme bereits serienreif
oder stehen kurz davor. Ändert sich die Umgebung hin zu Offroad, so
sind aufgrund anderer Nutzeranforderungen und vor allem aufgrund der
Umgebungseigenschaften in vielen Fällen andere Assistenz- und
Autonomiefunktionalitäten gefordert. In diesem Artikel stellen wir vom
Institut für Technik Autonomer Systeme (TAS) entwickelte
Funktionalitäten vor, die den Fahrer in Offroad-Szenarien entlasten
können. Zum einen handelt es sich hier um einen Konvoi-Assistenten,
der das spurgetreue Folgen hinter einem anderen Fahrzeug ermöglicht,
zum anderen um einen Mule-Assistenten für den Lastentransport zwischen
zwei Lagern. Anhand von zwei Wettbewerbsszenarien aus der M-ELROB 2016
werden diese Funktionalitäten evaluiert.
No Human – No Cry?
Authors: Bengler Klaus , Winner Hermann , Wachenfeld Walther
Published: July 2017

Die Argumentation für eine zunehmende Automation der Fahraufgabe wird
häufig von dem Argument begleitet, dass damit der
Mensch/Fahrer als Ursache für Unfälle aus dem System getilgt werden
könnte. Allerdings wird hierbei erstens
übersehen, dass Unfälle seltene und multikausal
verursachte Ereignisse sind. Der Mensch stellt also
nicht den Alleinverursacher, sondern in vielen
Fällen sogar die letzte sehr wichtige Sicherheitskomponente im
System. In jeder Hinsicht ist daher eine objektive
Betrachtung der Fehlerverteilungen und der statistischen Zusammenhänge
der Unfallentstehung sinnvoll.
Breastfeeding and the gut-brain axis: is there a role for melatonin?
Authors: Anderson George , Vaillancourt Cathy , Maes Michael , Reiter Russel J.
Published: July 2017

The benefits of breastfeeding over formula feed are widely appreciated. However, for many mothers breastfeeding is not possible, highlighting the need for a significant improvement in the contents of formula feed. In this article, the overlooked role of melatonin and the melatonergic pathways in breast milk and in the regulation of wider breast milk components are reviewed. There is a growing appreciation that the benefits of breastfeeding are mediated by its effects in the infant gut, with consequences for the development of the gut-brain axis and the immune system. The melatonergic pathways are intimately associated with highly researched processes in the gut, gut microbiome and gut-brain axis. As the melatonergic pathways are dependent on the levels of serotonin availability as a necessary precursor, decreased melatonin is linked to depression and depression-associated disorders. The association of breastfeeding and the gut-brain axis with a host of medical conditions may be mediated by their regulation of processes that modulate depression susceptibility. The biological underpinnings of depression include increased levels of pro-inflammatory cytokines, oxidative stress, kynurenine pathway activity and dysregulation of the hypothalamic-pituitary adrenal axis, all of which can decrease melatonergic pathway activity. The inclusion of the melatonergic pathways in the biological interactions of breast milk and gut development has significant theoretical and treatment implications, as well as being important to the prevention of a host of infant-, child- and adult-onset medical conditions.
Design, synthesis, docking and in vitro antifungal study of 1,2,4-triazole hybrids of 2-(aryloxy)quinolines
Authors: Somagond Shilpa M. , Kamble Ravindra R. , Kattimani Pramod P. , Joshi Shrinivas D. , Dixit Sheshagiri R.
Published: July 2017

Substituted quinolines containing a 1,2,4-triazole moiety were synthesized using reported methods. The molecular docking studies support the experimental results that these compounds are active against A. fumigatus and C. albicans where N-myristoyl transferase (NMT) and dihydrofolate reductase (DHFR), respectively, are the target enzymes. The analogues that contain methoxy and chloro substituents exhibit the best antifungal activity.
Factors in language learning after 40: Insights from a longitudinal study
Authors: Kozar Olga , Yates Lynda
Published: July 2017

This study seeks to identify differences in language learning progress and experiences among 24 adult migrants, who arrived to Australia after the age of 40. The results suggest that age per se was not a reliable predictor of language learning progress. Instead, the initial English level of participants when they arrived to Australia, opportunities to use English and prior level of education were associated with considerable language learning gains. For example, participants who had a higher initial English level were able to find jobs that required them to perform a range of oral and written tasks across different domain, which further improved their level, while participants who had a low initial level were mostly unemployed. Another common factor we noted among participants with high and reasonable gains but not among those who made little progress was a proactive attitude and the use of a range of language learning strategies beyond the classroom. The study also revealed differences in age construal among participants with high and reasonable gains and those who did not improve.
An image fusion system for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma
Authors: Toshikuni Nobuyuki , Matsue Yasuhiro , Ozaki Kazuaki , Yamada Kaho , Hayashi Nobuhiko , Tsuchishima Mutsumi , Tsutsumi Mikihiro
Published: July 2017

Background

During ultrasound-guided radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC), high echoic areas due to RFA-induced microbubbles can help calculate the extent of ablation. However, these areas also decrease visualization of target tumors, making it difficult to assess whether they completely cover the tumors. To estimate the effects of RFA more precisely, we used an image fusion system (IFS).

Patients and methods

We enrolled patients with a single HCC who received RFA with or without the IFS. In the IFS group, we drew a spherical marker along the contour of a target tumor on reference images immediately after administering RFA so that the synchronized spherical marker represented the contour of the target tumor on real-time ultrasound images. When the high echoic area completely covered the marker, we considered the ablation to be complete. We compared outcomes between the IFS and control groups.

Results

We enrolled 25 patients and 20 controls, and the baseline characteristics were similar between the two groups. The complete ablation rates during the first RFA session were significantly higher in the IFS group compared with those in the control group (88.0%vs. 60.0%,P= 0.041). The number of RFA sessions was significantly smaller in the IFS group compared with that in the control group (1.1 ± 0.3vs. 1.5 ± 0.7,P= 0.016).

Conclusions

The study suggested that the IFS enables a more precise estimation of the effects of RFA on HCC, contributing to enhanced treatment efficacy and minimized patient burden.
The Second World War in Southeastern Europe. Historiographies and Debates
Authors: Rutar Sabine
Published: July 2017

Introducing this special issue on historiographies and debates on the Second World War in Southeastern Europe, the author reflects on the conditionalities of a better balancing of research agendas in terms of the interdependencies between local dynamics and wider scales—be they the regional, national and transnational, or global dimensions of the war. She draws attention to the role the European Union has played in crafting public history, in which processes of ‘internationalizing’ and of ‘nationalizing’ the past have been entangled. She concludes that Southeast Europeanists could greatly enhance international research agendas by taking the lead in fostering a bottom-up, multiscale, and multiperspective history of postimperial, nationalizing societies at war.
Chronic Migraine, Comorbidity, and Socioeconomic Deprivation: Cross-Sectional Analysis of a Large Nationally Representative Primary Care Database
Authors: McLean Gary , Mercer Stewart W.
Published: July 2017

Background:

Chronic migraine is common but there is limited knowledge on associated comorbidities.

Objectives:

To examine mental and physical comorbidities in chronic migraine and the influence of socioeconomic status in a large, nationally representative dataset.

Design:

Analysis of cross-sectional primary healthcare data from 1,468,404 adults in Scotland. Chronic migraine, 31 other physical conditions, and seven mental health conditions we examined. Prevalence rates were standardized by age groups, sex, and socioeconomic deprivation, and adjusted odds ratio (aOR) and 95% confidence intervals (CI) calculated for those with chronic migraine compared with those without.

Results:

Chronic migraine patients had more conditions, with the biggest difference found for five or more conditions (chronic migraine 11.7% vs. controls 4.9%; aOR 3.00; 95% CI 2.78–3.22). Twenty-five of the 31 physical conditions were significantly more prevalent in the chronic migraine group. The biggest difference was for chronic pain (aOR 4.33; 95% CI 4.12–4.55). For mental health conditions, the biggest differences were for anxiety (aOR 2.95; 95% CI 2.76–31.5) and depression (aOR 2.94; 95% CI 2.81–3.08). Increasing deprivation was associated with more severe and complex comorbidity (five or more conditions), and with more combined mental and physical comorbidity in the chronic migraine group.

Conclusions

In a large nationally representative sample in primary care, comorbidity was most common in those with chronic migraine compared with standardized controls, and this was exacerbated by living in areas of higher deprivation.
The Usefullness of Green Coconut Water Supplementation in Overcoming The Toxic Effect of Mercury Chloride in The Blood and Blood Profile (Study in Sprague Dewly Rats)
Authors: Ehmeeda Abdulrzag , Kristina Tri Nur , Suwondo Ari , Sunoko Henna Rya
Published: July 2017

When people are exposed to mercury chloride, it can produce a variety of health effects in the blood and liver. Coconut water contains Zn, Fe, Vit. C, Vit B11, Vit. B6­, and Se to reduce mercury chloride level in the blood and improve blood profile. Aim of this study was to analysis the effect of green coconut water supplementation in overcoming the toxic effect of Hg chloride in the blood of Sprague dawley rats exposed to Hg chloride. Samples were randomly about 36 animals rats exposed to HgCl2 through forced feeding by 20 mg/kgBW sondage perday for 14 days, which divided into control group, and intervention groups were given fresh green coconut water in each by 6, 8, and 10 mL/kgBW for intervention 7 and 17 days. The result of this study showed that there is a significant effect and the decrease in mercury levels in the blood. There is no significant affect on the hemoglobin level, hematocrit level and platelet count with the treatment of green coconut water in the rats with exposure Hg. New findings/significance of contribution were the effectiveness of green coconut water to reduce Hg level in blood and improve blood profile.
Vitamin A, endocrine tissues and hormones: interplay and interactions
Authors: Brossaud J , Pallet V , Corcuff J-B
Published: July 2017

Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Two endocrine systems have been particularly studied. In the pituitary, retinoids target the corticotrophs with a possible therapeutic use in corticotropinomas. In the thyroid, retinoids interfere with iodine metabolism and vitamin A deficiency aggravates thyroid dysfunction caused by iodine-deficient diets. Retinoids use in thyroid cancer appears less promising than expected. Recent and still controversial studies investigated the relations between retinoids and metabolic syndrome. Indeed, retinoids contribute to pancreatic development and modify fat and glucose metabolism. However, more detailed studies are needed before planning any therapeutic use. Finally, retinoids probably play more minor roles in adrenal and gonads development and function apart from their major effects on spermatogenesis.
Zwischen Heroismus und Antiheroismus Ligetis Mikropolyphonie in 2001 revisited
Authors: Kutschke Beate
Published: July 2017

This article re-investigates the use of Ligeti’s second movement of his Requiem “Kyrie” (1963/1965) in Stanley Kubrick’s 2001 — A Space Odyssey (1968). It does so in light of allusions to heroic models and the – obviously – heroic Zarathustra fanfare, both of which are pervasive in Kubrick’s film. The article aims at determining compositional means that refer to heroic ideas in avant-garde music of the 1960s, a time period in which radically new and skeptical views of heroism came to the fore that also affected the articulation of the heroic in music.
Ende von Anfang an Wege zu György Ligetis San Francisco Polyphony
Authors: Luyken Lorenz
Published: July 2017

György Ligeti’s comments on his last large orchestral piece San Francisco Polyphony show a remarkable understatement, if not neglect, of this work. This paper intends to find reasons for this attitude. It analyzes the correlation between title and substance, in particular the description of the work as being polyphonic, showing that the piece is less polyphonic than it is melodic or even thematic, resulting from coherent stylistic development as well as from an innate spatial conception rather than from a switchback to 19th-century procedures. At the end, San Francisco Polyphony proves to be a very personal comment on the state of the post-war musical avant-garde and the discussion about postmodernism in music.
Memaknai Program Pemberdayaan Ekonomi Masyarakat Pesisir
Authors: Kurniasari Nendah , Reswati Elly
Published: July 2017

Pelaksanaan Program Pemberdayaan Ekonomi Masyarakat Pesisir (PEMP) dinilai mempunyai efektifitas yang rendah. Selama delapan tahun PEMP berlangsung, wilayah pesisir masih menjadi kantung kemiskinan di negara ini. Tulisan ini merupakan analisis singkat terhadap pelaksanaan PEMP dalam tataran konseptual dan tataran praktis. Hasil analisis diharapkan dapat menjadi pembelajaran bagi program pemberdayaan berikutnya. Dalam tataran konsep, PEMP telah memenuhi stategi mata pencaharian dan strategi permodalan untuk memutus rantai kemiskinan. Namun PEMP kurang mendapat perhatian dalam strategi makro, karena sektor kelautan dan perikanan belum menjadi pertimbangan penting dalam kebijakan nasional. Dalam tataran praktis, beberapa hal yang perlu diperbaiki yaitu merubah persepsi nelayan tentang makna bantuan, meningkatkan kapasitas sasaran dalam managemen dan administrasi keuangan, sinkronisasi antara berbagai program pemberdayaan, serta penyesuaian program dengan kultur sempat yang sangat bersifat lokalitas.
The association of the circle of Willis anomaly and risk of stroke in patients with carotid artery disease
Authors: Göksu Eylem Özaydın , Koç Pınar , Küçükseymen Elif , Ünal Ali , Genç Fatma , Gencer Elif Sarıönder , Yaman Aylin
Published: July 2017

ABSTRACT The circle of Willis is an important collateral system that maintains perfusion to the stenotic area from the contralateral carotid and basilar artery to the region of reduced brain perfusion. The aim of the present study was to compare the circle of Willis anomaly in patients with unilateral symptomatic and asymptomatic carotid artery disease. Results In this retrospective study, we analyzed 175 patients who presented at our outpatient stroke clinic between January, 2013 and June, 2015 with either unilateral symptomatic or asymptomatic carotid artery disease, and who had had CT angiography imaging performed. Demographic properties, carotid artery stenosis and the anomaly of the circle of Willis was recorded. Conclusion There was no statistically significant difference in patients with symptomatic and asymptomatic carotid artery disease in terms of the anomaly of the circle of Willis.
ID-Migraine™ questionnaire and accurate diagnosis of migraine
Authors: Mattos Ana Carolina Musser Tavares de , Souza Jano Alves de , Moreira Filho Pedro Ferreira , Jurno Mauro Eduardo , Velarde Luis Guilhermo Coca
Published: July 2017

ABSTRACT Objective To analyze the applicability of the Portuguese version of ID-MigraineTM in a sample of Brazilian patients. Methods Patients with headache were recruited from the neurology outpatient clinic of a tertiary hospital and submitted to the ID-MigraineTM questionnaire. The diagnosis of headache was made according to the ICHD-2 criteria. Results Of the 232 patients, 86% had migraine. The questionnaire showed a sensitivity of 92% (95%CI, 88% to 95%), specificity of 60% (95%CI, 43% to 77%) and a positive predictive value of 93% (95%CI, 89% to 96%). Discussion Our results were similar to other international studies of the ID-MigraineTM application. The Portuguese version is considered easy to use, and an appropriate screening tool for migraine diagnosis in our sample. Conclusion Considering the characteristics of our health system, we can infer that this questionnaire would be beneficial in a Brazilian primary care setting; however, more studies are necessary.
Late onset multiple sclerosis: concerns in aging patients
Authors: Lotti Claudia Beatriz de Campos , Oliveira Acary Souza Bulle , Bichuetti Denis Bernardi , Castro Isac de , Oliveira Enedina Maria Lobato
Published: July 2017

ABSTRACT Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the predominant disease course was primary progressive (64.3%). The patients reached the disability landmarks of EDSS grades 3.0, 6.0 and 7.0 in the following proportion and time: EDSS 3.0: 77.42% of patients in 3.7 years; EDSS 6.0: 58.06% in 5.1 years and EDSS 7.0: 32.26% in 5.7 years. The comparative analysis with a matched control group of patients with early onset MS showed that late onset, associated with a progressive course, were predictors of reaching EDSS 3.0 and 6.0 in a shorter time.
Quantitative Myasthenia Gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation
Authors: Oliveira Ezequiel Fernandes , Valério Berenice Cataldo Oliveira , Cavalcante Valéria , Urbano Jessica Julioti , Silva Anderson Soares , Polaro Melissa Nunes , Nacif Sergio Roberto , Oliveira Claudia Santos , Resende Maria Bernadete Dutra , Oliveira Acary Souza Bulle , Oliveira Luis Vicente Franco
Published: July 2017

ABSTRACT Objective To perform the translation, cross-cultural adaptation and validation of the Quantitative Myasthenia Gravis Score (QMGS) to Brazilian Portuguese in accordance with international ethical standards. Methods The following steps were taken: (1) implementation of the translation protocol and transcultural adaptation, (2) validation of the adapted content, and (3) assessment of reliability. To check intra- and inter-observer reproducibility, each patient underwent two interviews with interviewer-A and one with B. The QMGS was compared to the Myasthenia Gravis Composite Scale and Myasthenia-specific Quality of Life Questionnaire. Results Our study group consisted of 30 patients, with a mean age of 47.6±11.4 years and a mean duration of illness of 11.33±8.49 years. Correlation between the QMGS and MGC was very strong (r = 0.928; p < 0.001) and substantial between the QMGS and MG-QOL 15 (r = 0.737; p < 0.001). Conclusion The Brazilian Portuguese translation, and validation of the QMGS was successfully performed.
O SISTEMA PERSONALIZADO DE INSTRUÇÃO - UM RECURSO PARA A EDUCAÇÃO EM ENFERMAGEM
Authors: Carvalho Emília Campos de
Published: July 2017

A autora enfatiza as características e aplicações do Método Keller, um método de ensino individual. Salienta a viabilidade de sua aplicação em Enfermagem, quer no ensino formal ou em educação continuada.
Sensory and physicochemical characteristics of salamis added with vegetable-based curing ingredients
Authors: Kawski Vicky Lilge , Bertol Teresinha Marisa , Santos Maria José Honorato dos , Sawitzki Maristela Cortez , Fiorentini Angela Maria , Coldebella Arlei , Agnes Ingrid Beatriz Lermen
Published: July 2017

ABSTRACT: The aim of this study was to evaluate the sensory and physicochemical quality of colonial salamis added with vegetable-based curing ingredients as potential enhancers of quality products. Salamis were produced according to three treatments: (A) Control: 0.1% curing salt; (B) rosemary: 0.05% curing salt + 0.5% rosemary extract (RE); and (C) RE+celery: 0.14% Veg 503 + 0.27% Veg 504 (sea salt plus celery, nitrate and nitrite supplies, respectively) + 0.5% of RE. No significant differences were observed (P>0.05) among the three treatments for dry matter (DM), crude protein (CP), ash, ether extract (EE) and gross energy (GE). Sensory analysis was performed by applying the preference test and multiple comparison between the three treatments. Salamis added with vegetable-based curing ingredients were sensory equivalent to conventional level of curing salts. Vegetable extracts allowed the development of the sensory features of salami and did not interfere in the fermentation process. Results suggested that the extracts can serve as effective natural curing ingredients for the ripening process and cured meat color as well as adequate shelf-life replacing the commercial curing salts in meat and meat products. After 30 days of ripening, salami from the control treatment (conventional levels of nitrite and nitrate) and the treatments with added vegetable-based curing ingredients and low nitrite and nitrate content (RE and RE + celery) were equivalent in sensory quality.
Oviposition of Quesada gigas in weed no hostess: implication in pest management
Authors: Maccagnan Douglas Henrique Bottura , Matuo Tomás Kanashiro , Martinelli Nilza Maria
Published: July 2017

ABSTRACT: This study recorded the choice of dry plant of Conyza spp as oviposition site by cicada Quesada gigas (Olivier, 1790). We presented issues of natural history of the cicadas that indicate the inability of immatures to complete life cycle in this species of plant. Some implications on cultures where Q. gigas has economic importance are also discussed.
Portable X-ray fluorescence (pXRF) applications in tropical Soil Science
Authors: Ribeiro Bruno Teixeira , Silva Sérgio Henrique Godinho , Silva Elen Alvarenga , Guilherme Luiz Roberto Guimarães
Published: July 2017

ABSTRACT The X-ray fluorescence (XRF) is an analytical technique for determination of elemental composition of different materials. In soils, the XRF has many pedological, environmental and agronomic applications, mainly after the emergence of portable equipments (pXRF). This technique has been recently adopted and successfully used for soil characterization worldwide, but very rare works have been carried out in soils of developing countries. The soil characterization includes the complete elemental composition determination (nutrients, trace and rare-earth elements) and allows estimating some soil physical and chemical properties. In Brazil, this technique is still incipient, mainly the use of pXRF, however, it can greatly contribute to soil characterization in-field or in-lab conditions and also replacing methods of soil analyses considered non-environmentally friendly. This review summarizes the XRF technique including principles and the main applications of pXRF in soils highlighting its potential for tropical Soil Science.
Quantitative and qualitative damage caused by Oebalus poecilus (Hemiptera, Pentatomidae) to upland rice cultivated in new agricultural frontier of the Amazon rainforest (Brazil)
Authors: Krinski Diones , Foerster Luís Amilton
Published: July 2017

ABSTRACT Oebalus poecilus (Dallas 1851) is one of the stink bug species of great economic importance for rice producers in Brazil of irrigated, flood and upland cropping systems. These pentatomids are known as stink bugs of panicles, because both nymphs and adults feed mainly on panicles. Stink bug attacks result in pecky (spots) seeds, lower mass, germinative reduction and deformed grains. Bearing these factors in mind, the aim of this study was to evaluate the quantitative and qualitative losses in commercial cultivars of upland rice (Cambará variety), submitted to different population levels of stink bugs of panicles, O. poecilus, at different reproductive growth stages. The results show that in upland rice (Cambará variety), the rice grains are susceptible to quantitative (number and weight) and qualitative (pecky, atrophy, chalky and broken grains) damage during all panicle development. However, when the insects feed during anthesis/caryopsis and milky stage cause significantly greater percentage of empty grains (up to 83%) than when they feed of grains during later phases of panicle development. This characteristic was also observed for the reduction in grain weight. This information may benefit producers and other researchers, allowing them to focus on the monitoring efforts of O. poecilus in most susceptible phases of the attack of this insect. This will enable decision-making about what control measures should be taken, and when, in order to control stink bugs of panicles.
Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review
Authors: Margutti Karen Mello de Mattos , Schuch Natielen Jacques , Schwanke Carla Helena Augustin
Published: July 2017

Abstract Objective: To identify the relationship between inflammatory markers and sarcopenia, and the diagnostic criteria of the condition among the elderly. Methods: A systematic review was performed based on the consultation of the PubMed and LILACS databases. Eligible original articles were those involving individuals aged 60 years or more, which investigated sarcopenia [low muscle mass (MM) associated with poor muscle strength and/or reduced physical performance, according to the European Working Group on Sarcopenia in Older People consensus (EWGSOP)] or its diagnostic criteria, published in English or Portuguese, between 2010-2015. Results: Four articles were included in the review, the principle results of which were: the growth differentiation factor (GDF-15) exhibited a negative correlation with MM, handgrip strength and gait speed; the insulin-like growth factor-1 (IGF-1) correlated positively with MM; follistatin exhibited a weak correlation with physical performance; activin A and myostatin did not correlate with the diagnostic criteria; the highest tercile of extracellular heat shock protein 72 (eHsp72) was associated with lower median levels of MM, handgrip strength and gait speed; elderly persons with low MM had higher serum ferritin concentrations; women with low MM exhibited lower serum concentration levels of C-reactive protein (CRP). Conclusion: the six investigated inflammatory markers (GDF-15, IGF-1, follistatin, eHsp72, ferritin and CRP) were associated with the diagnostic criteria for sarcopenia, but not with sarcopenia itself. As research in this area is still developing, additional studies are required to broaden knowledge and eventually establish the role of these markers in the diagnosis and management of sarcopenia.