bluuebunny/crossref_metadata_2025 huggingface dataset:
Comorbidities in Patients before Surgical Myocardial Revascularization: Current State of the Problem. Part IІ
Authors: Gogayeva Olena K. , Lebid Alina Yu. , Tymoshenko Dmytro A.
Published: September 2022

The first part of the article was dedicated to the problem of comorbidities in cardiac surgery patients with coronary artery disease (CAD), considered modern literary sources discussing endocrinopathies, connective tissue diseases, COVID-19-associated autoimmune processes, chronic kidney disease and diseases of the gastrointestinal tract.

The aim. To continue the analysis of current literature data on comorbidities in patients hospitalized for surgical myocardial revascularization.

Results. When assessing the preoperative status of a cardiac surgery patient with CAD, not only their cardiological status and the percentage of stenotic lesion of the coronary arteries are important, but also the presence of concomitant diseases and the degree of their compensation. According to the modern literary sources, 4-20.5% of patients undergoing coronary artery bypass grafting (CABG) have chronic pulmonary disease (COPD). In order to avoid bronchopulmonary complications in the postoperative period, high-quality preoperative diagnosis based on spirometric research is important. When verifying COPD, even of a moderate degree, a course of preventive therapy is required, and in the case of a severe course of COPD with a forced expiratory volume <50%, the involvement of a pulmonologist is necessary. Hemodynamically marked stenoses of brachiocephalic arteries are found in 6-12% of patients before CABG. According to European recommendations, ultrasound screening of carotid arteries is indicated for patients ≥70 years of age with multivessel lesions of the coronary arteries and a history of neurological disorders <6 months before planned cardiac surgery. Dementia is diagnosed in 9.6-20% of patients before CABG and is characterized by a higher rate of mortality and postoperative complications. It was established that the result of the cognitive function assessment using the Mini-Mental State Examination (MMSE) scale <24 is an independent risk factor for in-hospital mortality and postoperative delirium. Concomitant disease of peripheral arteries is diagnosed in 6.1-20.4% of patients before CABG and negatively affects both immediate and long-term results of myocardial revascularization.

Conclusions. Timely verification and compensation of comorbidities is an important point in the perioperative management of cardiac surgery patients with CAD. The systemic nature of the atherosclerotic process leads to multifocal stenotic lesions of the arterial system, which requires from the heart team not only to determine the priority of surgical interventions, but also to choose the optimal method of myocardial revascularization, taking into account comorbidities.
Problems of preserving and actualization the heritage of folk-art crafts
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture», Semerickaja Olga Vladimirovna
Published: September 2022

Folk art crafts are a unique cultural phenomenon, the preservation and actualization the heritage of which seems to be the one of the ecological problems in the light of the recognition at the state level and in the scientific community of the importance of the successive development of culture in the interests of society. The heritage of folk-art crafts in all their type and species diversity has a high information potential as a cultural phenomenon and value as a carrier of the cultural code of national and local significance, however, being outside the understanding of cultural heritage as a valuable part of social memory, it is excluded from the process of sustainable development of society. Studying the history of folk-art crafts in a wide historical and cultural context, defining the episteme of the heritage of folk-art crafts – these are the priority tasks for introducing the heritage of folk-art crafts into the integral system of cultural heritage as its organic part with the aim of further developing measures for its preservation and inclusion in the current culture. For the first time, the article presents a scheme of periodization of the general development of folk art crafts on the basis of the adaptive-activity approach to the culture of E. S. Markaryan, the current directions of the study of folk art crafts at the same time as an economic and cultural phenomenon are identified, the forms of actualization of the heritage of crafts that exist today are analyzed and the current risks associated with the commodification of the heritage of folk art crafts are identified.
Introduction of cluster technology in the educational process of the university
Authors:   Professional and Further Education Pedagogy Surgut State University, Muller Ol’ga Yur’evna
Published: September 2022

Abstract. The article discusses cluster technologies in the field of education, based on the synthesis of systems theory and cognitive science, providing the ability to manage systems, including the educational system, to ensure the best results and efficiency. The cluster approach involves a fresh look at the process of education (training), which allows us to consider the relationship, continuity and mutual influence of various elements of the educational system on its results. In educational activities, cluster technology is used in the process of studying material within the framework of academic subjects for the best understanding of complex phenomena. The purpose of the study is to consider the essence and structure of the concept of «cluster technology» and determine the effectiveness of its application. Methods used in the study: literature review, pedagogical experiment, comparative analysis. The experiment involved two groups of students, one of which mastered educational material on cluster technology in accordance with the methodology of M. A. Veryaskina and E. I. Zaikina. As a result of the study, it was confirmed that the possibilities of using cluster technology in the educational process should be considered an effective tool for the didactic presentation of complex phenomena. The study conducted by the author showed that the introduction of cluster technology in the educational process of the university shows an effective result.
The algorithm of pedagogical support for the formation of flexible competencies
Authors:   Nizhny Novgorod Institute of Education Development, Udalova Raisa Ivanovna
Published: September 2022

The atlas with a list of new professions confirms the idea that system thinking is one of the most sought-after skills of the future, as a result, system thinking is related to 4K competencies. Flexible competencies (softskills) are especially important in modern education, in achieving personal, subject, meta-subject results by schoolchildren, along with skills that will be related to professional activity in a particular field, the definition of spiritual and moral, general cultural, general intellectual value orientations of a growing personality in the future. The analysis of the relationship of 4K with the requirements of personal results of the federal state standards of primary general education and basic general education allowed us to identify the actual vector of the practical value of flexible competencies, namely, the ability to build communication (communication), creatively (creatively) perform certain tasks, the ability to critically evaluate information and work effectively in a team, interacting with each other in real, sometimes in crisis conditions of society. The formation of flexible competencies among students based on the methods used to study, analyze information sources, experiment, modeling, design, planning, design, updated format of extracurricular activities, the algorithm proposed in this paper, made it possible to make the process of achieving results as effective as possible.
Problems of classification and study of scientific graphics of the XVII century
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture», Arutyunyan Yuliya Ivanovna
Published: September 2022

The principles of typology of scientific illustration can base on the classification system of sciences: natural (anatomy, medicine, botany, zoology, geography, astronomy, etc.), exact, social (regional history, archaeology, heraldry and genealogy). Technical illustration (mathematics, physics, chemistry) and applied graphics, images in works related to body techniques are considered separately. Classification by type of publications, by the ratio of text and visual series is acceptable: treatises, overages, catalogs. Classification by methods of description is possible: scientific work, travelogue, educational publication, illustrated list. Methodological approaches to the analysis of illustration: iconological, visual studies, multidisciplinary - form the research base for the study of scientific graphics.
The specifics of modern vocal variety art in Russia
Authors:   St. Petersburg State Conservatory on the N. A. Rimsky-Korsakov, Zhang Yinran
Published: September 2022

Vocal pop art is a fundamentally important social institution that is very actively functioning in the modern system of Russian culture. During his research, the author comes to conclusions about the versatility and multifunctionality of modern vocal pop art in Russia, its enormous ideological and applied significance for the current and future development of society. In addition to a considerable number of positive development prospects, it is also noted that in this context there are certain problematic sectors, such as the stereotypical perception of pop songs by ordinary people and some researchers, insufficient elaboration of didactic (including methodological) methods of teaching student vocalists, insufficient attention of reference groups to the huge creative and ideological potential of this type of musical art. The main conclusion of the author was that vocal pop art is a strategically significant resource for the development of domestic cultural capital.
Integration of activities of library, university and professional public organizations for library specialists training
Authors:   Pushkin Tambov Regional Universal Scientific Library, Pronina Ljudmila Alexeevna
Published: September 2022

It is proposed to integrate the activities of libraries, universities and public organizations, including the training of library specialists, as a mechanism for library advocacy on the example of the Tambov region. Qualification characteristics, requirements for library specialists training through the “binding” of hard skills and soft skills, ways of educational process redesign and academic disciplines are determined. Examples of integration of university, library and public organization are given. The ways of library personnel training system improvement, including obtaining an additional qualification “Information / Digital Curator” and developing social partnership, are proposed. The proposed mechanism contributes to library advocacy to protect the interests of libraries and increase library profession prestige.
Utopia or reality? The slogan of the whites: «The Tsar and the Soviets»
Authors:   College GBPOU ZKNO, Arifullin Farit Munerovich
Published: September 2022

Review of the monograph: Bazanov P. N. The Tsar and the Soviets: Russian emigration in the struggle for Russian statehood: political and publishing activity. – Saint-Petersburg: Russ. Christian Humanitarian Acad., 2021. – 334 p. – ISBN: 978-5-907505-26-1 Monograph by P. N. Bazanov, devoted to three currents of the Russian Diaspora: Smenovekhovites, post-revolutionaries and Young Russians, who were united by the idea of the meaninglessness of the struggle against the Soviet system. They believed that Soviet power was gradually evolving, the Young Russians advocated the revival of the monarchy.
Performative practices in the design of national identity images
Authors:   Herzen State Pedagogical University of Russia, Antonian Karina Georgievna , Sokolova Nina Aleksandrovna ,   Peter the Great St. Petersburg Polytechnic University
Published: September 2022

The article examines the phenomenon of national identity as a performance. Performance of national identity is ways in which the nation is (re)produced, from state-sanctioned ceremonies to the quotidian acts. Performance is a useful metaphor since it allows to look at the ways in which identities are enacted and reproduced. Performance continually reconstitutes national identity by rehearsing and transmitting meanings. The notion of performance also foregrounds identity as dynamic, as always in the process of production. The nation continues to be an influential category for defining a community based on language, territory, and a common past. Art, science, politics, economics are painted with a specific national flavor. National cultures in the global world strive for a universal human context on the one hand. On the other hand, to the definition of national identity. National identity is performative. National identity is a process consisting of many events, both official and every day.
Cultural and educational project «Memory Through the Years» as an experience of museum interaction with visitors
Authors:   Peter the Great Museum of Anthropology and Ethnography (the Kunstkamera) RAS, Petrova Alexandra Arkadievna
Published: September 2022

The project «Memory Through the Years» had been implemented in 2020–2021 jointly by the MAE (Kunstkamera) RAS and the House of Children’s Creativity «On the 9th Line» of the Vasileostrovsky District, St. Petersburg. The project dedicated to the 75th anniversary of the Victory in the Great Patriotic War was timed to the Year of Memory and Glory. The project was attended by high school students of the Vasileostrovsky District of St. Petersburg, activists of the Headquarters of the Russian Schoolchildren Movement «Civic Activity». The teenagers created a documentary film about the MAE, representing their own view of the museum’s inner life. The film won several awards at film festivals. A scheme of interaction between the museum and an educational institution was based on the material and technical basis of both organizations without additional funding. The project participants were able to attract their peers to the museum. This allows the MAE to map out the implementation of various sociocultural and educational events with a new audience.
The main street of Tver’: the history of renaming in the context of ur-ban-building and socio-cultural
Authors:   the Russian Academy of Architecture and Construction Sciences (RAASN), Salimov Alexey Maratovich
Published: September 2022

Like any city, Tver’ has its own main street, and given the fact that the time of the foundation-capital of the Upper Volga goes into the Middle Ages, and the formation of its main urban «highway» took place several centuries ago. This street existed during the period of the independent Tver’ Principality, but the earliest documentary evidence of it dates only to the 17th century. Then this street was called «Big Moscow». From the second half of the XVII century schematically it began to fix the cartographers and on the plan of the first quarter of the XVIII century we already have a quite clear idea of this magistral. Its curvilinear, medieval-oriented character persisted until the 1760s when Tver’ after the fire of 1763 was reformed based on the «regular» town planning decision. Since then, the late medieval street name has been removed from the city toponymy. There is a Tverskaya perspective, although for some time there is a synthetic name – Great Tver’ Prospect. Later, in gratitude for the exceptional care in restoring the city after the fire, the head-street of Tver’ began to be called Ekaterininskaya street. An attempt to change this name was made in the early 1810s Prince G. Oldenburg in his time as Governor-General of the Tver’ Governorate. However, the new name of the main street of Tver’ – Millionaire – did not exist enough. It went out of circulation a few years after the death of Oldenburg (in 1812). As a result, they returned to Yekaterininskaya street again, and in the 1870s. Perhaps because of the increasing wealth of most of the residents of this street, it was again called Millionaire. It remained so until the end of the 1910s. After the revolutionary events of 1917, it was renamed Soviet.
Industrial heritage: to the development of a classification
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture», San’kova Anna Sergeevna
Published: September 2022

The preservation of industrial heritage objects is an urgent task of our time for many countries. To solve the problem, it is necessary to determine the cultural, historical and architectural value of the surviving buildings, and to choose the preferred option for their use: museumification, business or commercial use, restart production. At the same time, the specific criterion for evaluating industrial heritage objects is often not uniqueness, but, on the contrary, representativeness – typicality for a particular production. This raises the question of developing a classification of industrial heritage objects. The article provides an overview of currently existing options for such a classification, highlights new grounds for grouping objects, and presents attempt to include objects of intangible industrial heritage into а general classification.
Kistik Fibrozis Tarama Testi Sonucu Yanlış Pozitif Olan Vakalarımızın Literatür Eşliğinde Değerlendirilmesi
Authors: YENDUR Ozge , GÜNDOĞDU Zuhal , GÜRKAN Metin
Published: September 2022

Amaç: Kistik fibrozis (KF); tekrarlayan akciğer enfeksiyonları, mekonyum ileusu, pankreatik yetmezlik gibi bulgularla seyreden ve birden fazla sistemi tutabilen, yenidoğan döneminden başlayabilen kronik bir hastalıktır. Kistik fibrozis otozomal resesif geçişli bir hastalık olup ülkemizde sıklığının 1/2500-1/3000 olduğu düşünülmektedir1. Hastalığın erken tanısını koyup erken tedaviye başlayabilmek için Türkiye’de 2015 yılında yenidoğan tarama programlarına KF tarama programı eklendi ve İmmünoReaktif Tripsinojen (IRT) enzimini ölçmeye dayanan bir testtir2. Araştırmamızda, iki KF tarama testide pozitif olup Çocuk Sağlığı İzlem Polikliniği’ne gönderilen bebekleri klinik ve ter testi sonucuyla beraber değerlendirerek KF tarama testi yanlış pozitifliklerin nedenlerini irdelemeyi amaçladık.
Yöntem: Retrospektif yaptığımız bu çalışmada KF yenidoğan tarama testleri pozitif olduğu için 2018 yılında gönderilen bebeklerimizin ter testleri sonuçlarını ve klinik bilgilerini dosya kayıtlarından elde ettik. Çalışmaya başlamadan önce Etik Kurulu onayı alındı. Klinik ve ter testi sonuçlarına göre KF riski yüksek olan hastalarımız kesin tanı için KF referans hastanesine yönlendirilmişti. KF tanısı almayan ve tarama testleri yanlış pozitif olan vakaların sosyodemografik bilgileri, öykü, fizik muayene, prognozları ve test bilgileri ile tarama testleri sonuçları birlikte değerlendirilerek yanlış pozitifliğe neden olan faktörler istatiksel olarak analiz edildi.
Bulgular: Çalışmaya aldığımız 16 vakanın demografik bilgileri ve prognozları çizelgelerde belirtilmektedir. Polikliniğe başvurdukları ilk gün yaşları ortalama 133,75±82,15 günlüktü (%57’si erkek bebekti). Doğum haftası ve tartısı, YDYBÜ’ sine yatış ve antibiyotik alma süresi, uzamış sarılık, kardeş ölümü ve ilk mekonyumun gecikme öyküsü tarama testleriyle istatiksel olarak anlamlı ilişkili bulunurken diğer bulgularla aralarında anlamlı ilişki bulunmadı.
Sonuç: Bu çalışmada KF tarama testinde yanlış pozitifliğin olabileceği ve bunu açıklayan faktörler olduğu tekrar vurgulanmış oldu. KF tarama testinin yanlış pozitifliğinin fazla olduğu bilinmesine rağmen tarama testi pozitif olan her hastaya ter testi kesinlikle yapılmalıdır. Kliniğinde şüpheli bir bulgusu olan ve/veya ter testi arada bir değerde olan ve/veya KF risk faktörü taşıyan her bebek tekrar değerlendirmeli ve kliniğinin ilerleyen aylarda da çıkabileceği unutulmamalıdır.
New EU Instruments for Education: Vertical, Horizontal and Internal Tensions in the European Qualifications Framework
Authors: Elken Mari
Published: September 2022

Traditionally constrained by the Treaty to subsidiary action, a number of innovative approaches for joint European coordination in the area of education have emerged in recent years. This article analyses a particular new European Union (EU) instrument for education – the European Qualifications Framework (EQF) – by examining the vertical, horizontal, and internal tensions within the instrument. Analysis of the vertical dimension identifies widening EU capacity for joint coordination through an informal widening of the subsidiarity principle and opportunities for diffusing EU preferences. Analysis of the horizontal coordination processes suggest that there is still some fragmentation in terms of coordinating the EQF across relevant sectors, even if emerging coordination can be identified in some areas. The internal tensions are related to the nature of the instrument that covers all levels and types of education. It is argued that these internal tensions remain, but the EQF has facilitated the development of a new arena for discussing policy coordination (EQFAG) that can, in the long run, reduce these tensions. While the impact of the EQF has been uneven and its implementation proceeded with various speed at this point, it nevertheless is a successful case of a particular Commission policy preference that has been gaining widespread acceptance across Europe in an area where coordination previously had been met with resistance.
Manajemen Perencanaan Kurikulum Bahasa Arab (Tinjauan Ontologi, Epistemologi dan Aksiologi)
Authors: Ulin Nuha Muhammad Afthon , Faedurrohman Faedurrohman
Published: September 2022

Makna perencanaan sesungguhnya tidak berangkat dari sesuatu yang hampa, dalam arti sudah ada beberapa data awal yang diistilahkan dengan “ide” yang selanjutnya akan dituangkan dalam program. Adapun perencanaan kurikulum merupakan perencanaan kesempatan-kesempatan belajar yang dimaksudkan untuk membina siswa atau peserta didik ke arah perubahan tingkah laku yang diinginkan dan menilai sampai manaperubahan-perubahan telah terjadi pada diri siswa/peserta didik. Hal ini sangat diperlukan untuk mencapai tujuan pendidikan nasional, maka perencanaan kurikulum harus selalu dilakukan secara berkala tak terkecuali dalam Bahasa Arab, oleh karena itu kurikulum bahasa Arab perlu dikembangkan karena perkembangan masyarakat dan peserta didik sangat dinamis. Berangkat dari hal tersebut penulis menganggap perlu mengemukakan manajemen perencanaan kurikulum bahasa Arab ditinjau dari ontologi, epistemologi, dan aksiologi. Dengan menggunakan metode library research, yang selanjutnya diolah dengan menggunakan pendekatan induktif ataupun deduktif diharapkan dapat menghasilkan kesimpulan bagaimana merencanakan kurikulum Bahasa Arab yang baik dan dapat diterima dalam pendidikan nasional.
تعليم المفردات باستخدام كتاب "رأس سيراه" في المدرسة الدينية مفتاح الكرامة كراطان فاسوروان جاوى الشرقية
Authors: Farid Edi Kurniawan , Firdausiyah Azizatul
Published: September 2022

AbstractTeaching vocabulary using the book "Ra'sun Sîrāh" in the Madrasah Dîniyyah Miftāh al-Karāmah Kraton Pasuruan East Java has advantages and teaching with it has characteristics. This research aims to (a) describe the advantages and disadvantages of the book "Ra'sun Sîrāh" for teaching vocabulary and (b) to explain the teaching of vocabulary by using it in this school. This qualitative research uses observation, interviews, and documentation in data collection. And the method of analyzing data uses interactive analysis of Mills and Huberman and testing its validity by triangulating the sources. The results of this research are the advantages of the book "Ra'sun Sîrāh" in teaching vocabulary (1) The book contains primer vocabulary, so it is beneficial for students who want to learn Arabic at the beginner level. Arabic vocabulary with its Javanese meaning is written and formed into poetry verses (naẕm). (3) students can recite it by singing the rhythms so that it is easier for students to learn vocabulary, and students can learn with pleasure. On the other hand, there are some disadvantages while using this book, (1) the students had difficulty understanding the meaning of the Javanese vocabulary in the naẕm. (2) The students had difficulty reading the meaning of the vocabulary using the writing "pego". (3) The students faced heavy and bored with the repetition method. (4) The teacher faced difficulty in developing the memorization method. Teaching vocabulary was implemented using this book through the singing method, the simulation and memorization method, and the questions and answers method. مستخلص البحثتعليم المفردات باستخدام كتاب "رأس سيراه" في المدرسة الدينية مفتاح الكرامة كراطان فاسوروان جاوى الشرقية له مزايا والتعليم به له خصائص. هدف هذا البحث إلى (أ) وصف المزايا والعيوب لدى كتاب "رأس سيراه" لتعليم المفردات و(ب) كشف تعليم المفردات باستخدامه في هذه المدرسة. استخدم هذا البحث الكيفي الملاحظة والمقابلة والتوثيق في جمع البيانات. وطريقة تحليل البيانات بالتحليل التفاعلي لميلس وهوبرمان واختبار صحتها بتثليث المصادر. ونتائج هذا البحث هي إن مزايا كتاب "رأس سيراه" في تعليم المفردات (1) يحتوي الكتاب على مفردات أساسية لذلك فهي مفيدة جدًا للتلاميذ الذين يرغبون في تعلم اللغة العربية على مستوى المبتدئين. (2) يتم ترتيب المفردات مع معناها الجاوي وتشكيلها في نظم بسيط. (3) يمكن للتلاميذ تلاوة النظم من خلال غناء النظم حتى يسهل على التلاميذ تعلم المفردات، كما يمكن للتلاميذ التعلم بكل سرور. وبجانب آخر هناك بعض العيوب من استخدام هذا الكتاب وهي (1) كان التلاميذ لهم صعوبة في فهم معنى الجاوية من المفردات في النظم. (2) كان التلاميذ لهم صعوبة في قراءة معنى المفردات باستخدام كتابة "فيكو". (3) يشعر التلاميذ بالثقل والملل من طريقة التلقين المتبعة. (4) واجه المعلم صعوبة في تطوير طريقة الحفظ. وتم تنفيذ تعليم المفردات باستخدام هذا الكتاب عن طريقة الغناء، وطريقة المحاكاة والحفظ، وطريقة الأسئلة والأجوابة.
Influencia de los actores sociales en la circulación comercial de especies vegetales en ferias y mercado de la ciudad de Córdoba (Argentina) y sus alrededores
Authors: Zamar María Agustina , Trillo Cecilia
Published: September 2022

Introducción y objetivos: Las ferias y mercados presentes en las ciudades son muestra del patrimonio biocultural de una región. El objetivo de este trabajo es identificar y caracterizar los actores sociales y los sitios de expendio, además de determinar su relación con la agrobiodiversidad, en ferias y mercados de la ciudad de Córdoba y alrededores. 
M&M: A partir de observación participante, entrevistas con distinto grado de estructura, se visitaron 30 ferias municipales (FM) y 5 agroecológicas (FA). Se realizó censos de especies y de productos. Se efectuaron análisis de la Varianza e índices de similitud (Sörensen) entre los distintos puntos de expendio. 
Resultados: Los actores sociales identificados en la comercialización fueron, en FM, “feriantes” o “puesteros” (manejan 49 especies, en mayoría exóticas); en FA, “productores agroecológicos”, “distribuidores” o “elaboradores” (manejan 49 especies, en su mayoría nativas). Además, se identificó la presencia de vendedoras ambulantes (ofrecen 8 especies de raíz andina). Las especies tienen mayor similitud entre FM y FA que entre ferias y vendedoras ambulantes.  
Conclusiones: La complementariedad y diferencias entre las ferias y el mercado dependen de las características de los actores sociales involucrados, la relación comprador/vendedor, sus conocimientos botánicos, valores personales, culturales y económicos que determinan e influye en la agrobiodiversidad presente; todos desarrollan  estrategias de venta que combinan “tradición” e “innovación”. Las diferentes opciones en los mercados favorecen la formación de un conocimiento botánico urbano complejo y dinámico
Conocimiento botánico y prácticas asociadas a la alimentación de caprinos en momentos de emergencia: tradiciones mantenidas por los productores cabriteros del Chaco Árido de Catamarca, Argentina
Authors: Quiroga Alejandro , Trillo Cecilia
Published: September 2022

Introducción y objetivos: Diferentes estudios etnobotánicos realizados en sistemas ganaderos de la Argentina han puesto de relieve la importancia de los conocimientos que los ganaderos criollos poseen sobre las plantas de su entorno. El  trabajo se propuso documentar y analizar el conocimiento tradicional que los ganaderos poseen sobre las plantas utilizadas en la alimentación de emergencia de caprinos bajo manejo extensivo en el Chaco Árido de la provincia de Catamarca y analizar las prácticas asociadas al manejo de esos recursos forrajeros.
M&M: Con el acompañamiento de 17 colaboradores claves, de ambos sexos que viven en 12 localidades distribuidas en los diferentes ambientes que integran el Chaco Árido, se realizaron entrevistas abiertas,  semiestructuradas y caminatas guiadas con productores ganaderos nacidos en la zona dedicados a la cría extensiva de caprinos de raza criolla.
Resultados: Se identificaron 28 especies de plantas vasculares utilizadas en cinco diferentes estrategias de alimentación de emergencia. Se aportan datos etnobotánicos sobre el nombre de las plantas, las partes utilizadas en la alimentación de los caprinos, el lugar y forma de recolección, modo de transporte y acondicionamiento, momento de utilización y categoría de animales alimentados. Se identifican múltiples y complejas necesidades que motivan a realizar este tipo de alimentación.
Conclusiones: Se espera que el valioso conocimiento etnobotánico aportado por  los campesinos cabriteros contribuya a perfeccionar las  futuras estrategias de alimentación de emergencia del ganado caprino y la conservación de las forrajeras nativas utilizadas en estas prácticas.
Las plantas que alimentan el fogón: primeros resultados del registro fitolítico de estructuras de combustión de Cueva de los Catalanes (Araucanía, Chile)
Authors: Roa Solís Constanza , Zurro Débora
Published: September 2022

Introducción y objetivos: El manejo del fuego es una temática ampliamente tratada en Arqueología, generalmente mediante análisis antracológicos y carpológicos. El análisis de fitolitos complementa a estas técnicas gracias a ventajas de los silicoficolitos: 1) se conservan en muy variados ambientes, sin requerir carbonización ni condiciones especiales; 2) dan cuenta de distintas categorías taxonómicas y de distintos órganos de las plantas. El presente estudio busca identificar la señal vegetal específica de las estructuras de combustión de la Cueva de los Catalanes, en comparación a áreas sin evidencias de combustión y a lo largo de la secuencia ocupacional.M&M: El material analizado corresponde a muestras de sedimento de los distintos niveles de ocupación y de las estructuras de combustión de Cueva de los Catalanes. Se llevó a cabo el análisis de fitolitos y el procesamiento estadístico de los datos.Resultados: Se sugiere que los conjuntos fitolíticos se comportan de manera muy heterogénea. No obstante, aquellos provenientes de las estructuras de combustión presentan mayores abundancias y diversidad de silicofitolitos. Asimismo, las muestras prehispánicas son más ricas en fitolitos y el espectro muestra algunas características diferentes, que se correlacionan con mayores densidades de los materiales arqueológicos.Conclusiones: El análisis de silicofitolitos se presenta como una herramienta útil y complementaria para entender el manejo del fuego en la región de estudio, con amplio potencial pobremente explorado.
Prolactinoma or leiomyoma-associated hyperprolactinemia—this is the question, a case report and review of the literature
Authors: Robeva Ralitsa , Ivanova Radina , Kamenova Teodora , Elenkova Atanaska , Zacharieva Sabina
Published: September 2022

Background: Hyperprolactinemia is a common finding in women of reproductive age that could result from physiological factors, pathological conditions or the use of different medications. The therapeutic approach depends on the etiology of hyperprolactinemia, thus, the proper diagnosis is paramount. Case: Herein, we present a case of a young woman with pituitary incidentaloma and leiomyoma-associated hyperprolactinemia. The initial diagnosis was microprolactinoma, based on typical clinical features, increased prolactin levels, and pituitary adenoma. However, dopamine agonist treatment did not lead to any reduction of prolactin levels or clinical improvement. The patient was myomectomized because of uterine fibroid enlargement. After the surgery, the hyperprolactinemia resolved completely, while the pituitary adenoma did not show any changes. The concomitant development of pituitary adenoma and extrapituitary hyperprolactinemia might not be such a rare phenomenon, considering the high prevalence of pituitary incidentalomas. Conclusions: Currently, there are no specific tests that could distinguish pituitary from extrapituitary prolactin production. Our case report and the literature review show that leiomyoma-associated hyperprolactinemia should be considered in women of reproductive age with treatment-resistant prolactinoma and uterine fibroids above 5 cm. Further studies are needed to explore the underlying mechanisms and the possible regulators of the ectopic prolactin secretion.
A Clinical Trial of Wrist-Ankle Acupuncture for Abirritation during High-Intensity Focused Ultrasound Treatment of Adenomyosis
Authors: Liu Chenning , Lin Xiaoyang , Liu Yuhui , Zhao Meiduo , Shen Qiuxian , Tang Li , Wang Yanqin , Zhou Xiaojuan , Liu Huituan , Yu Hongjin
Published: September 2022

Background: Wrist-ankle acupuncture (WAA) has promising analgesic effect during high-intensity focused ultrasound (HIFU), but evidence-based clinical test is scarce. The purpose of this research is to assess the efficacy of WAA for relieving pain during HIFU treatment of adenomyosis. Methods: Fifty-eight patients with adenomyosis treated with HIFU were enrolled in this study. Among them, 30 patients chose the WAA group, and the others selected the pethidine injection. The visual analog scale (VAS) pain score was recorded to assess the pain during HIFU before and after analgesic therapy. The VAS at 10 min, 30 min and 1 h after analgesic therapy, and the adverse effects, were noted and calculated to compare these two approaches. Results: The median pain score in the WWA group at 10 minutes was 6 [6, 7], which was higher than that in the control group it was 5 [4, 6] (p < 0.001). At 30 min and 60 min, the pain scores were 5 [4, 6] in the WAA group and in the control group. The statistically significant differences were not found in pain relief scores at 30 or 60 min (p > 0.05). No side effects were observed in the WAA group. Conclusions: WAA is a safe and easily available technique to reduce the pain during HIFU treatment, with no severe effects. Thus, it can be widely used and promoted in clinical practice.
Urinary Incontinence after Iatrogenic Bladder Injury during Cesarean Section. A Ten-Year Single-Center Retrospective Analysis and Review of the Literature
Authors: Cicuti Marta , Manodoro Stefano , Bosio Sara , Marconi Anna Maria
Published: September 2022

Background: Bladder injuries during caesarean delivery are rare but serious intraoperative complications. Short-term effects of bladder injuries include prolonged catheterization and urinary infections. Nevertheless, there is a lack of data regarding long-term adverse outcomes, such as lower urinary tract dysfunctions. Our aim is to retrospectively analyze the long-term prevalence of urinary incontinence after iatrogenic bladder injury occurring during caesarean delivery in a singleton first-level Obstetric Department. Moreover, with a systematic review we aimed to define on urinary symptoms, primarily urinary incontinence. Methods: All patients who underwent caesarean delivery with bladder injuries in our first-level obstetrics department between 1st January 2010 and 31st December 2020 were included and reached for a telephone interview during 2021. Moreover, a systematic literature review was conducted up to November 28, 2021. Data selection and extraction were conducted in accordance with PICOS (Population, Intervention, Comparison, Outcome and Study design) criteria for study selection, using a piloted form specifically designed for capturing information on the study and characteristics. Results: Throughout the obstetrics database of our department, we identified 16 patients with iatrogenic bladder injury in 3725 caesarean delivery, with an overall incidence of 0.43%. Ten patients out of 16 (63%) attended the interview and four of them (40%) developed urinary incontinence. Three studies met the criteria for the systematic review. The incidence of bladder injuries varied from 0.05 to 0.47%. The incidence of urinary incontinence ranged from 4.9 to 37.5%, regardless the type of incontinence with no information about any treatment need. Conclusions: The incidence of bladder injuries associated with caesarean delivery in our population was similar to levels reported in the literature. Even if out of only three papers, the incidence of urinary incontinence resulted in a wide range among authors. In conclusion, urinary incontinence seems to be related to iatrogenic bladder injury during caesarean section, but, due to the lack of additional data, more studies are needed to precisely define the causality link.
Anxiety and Difficulties of Infertile Women. The Moderating Role of Attachment Pattern
Authors: Iordăchescu Diana Antonia , Boca Alina Estera , Paica Corina Ioana , Bălănescu Paul , Panaitescu Anca Maria , Peltecu Gheorghe , Gică Corina , Buică Alexandra , Gică Nicolae
Published: September 2022

Background: The present study focuses on examining the association between attachment pattern, anxiety and perceived infertility-related difficulties of women with fertility concerns. Also, the study explores the moderating role of attachment in the relationship between infertility duration and perceived difficulties, but also in the relationship between anxiety and infertility difficulties. Methods: Our study is a descriptive, correlational one. Quantitative data was used, employing transversal and quantitative analysis, thus proving the study to be an experimental one. Survey data was obtained from a total of 240 women with fertility problems (N = 240), aged between 22 and 46 years old (M = 32.71, SD = 4.85). Results: Results show that participants with a pattern of secure attachment had obtained lower scores on state anxiety, trait anxiety and the difficulties scale compared to those with an avoidant one. Also, women that had undergone repeated in vitro fertilization procedures had significantly higher avoidant attachment scores than those that had undergone a single treatment procedure. Another important result is that avoidant attachment moderates the relationship between trait-anxiety and the global difficulties perceived by infertile women. Conclusions: The results of the study show that women can be deeply affected by failed fertilization attempts and repeated miscarriages; as a consequence, they might feel powerless because they cannot become mothers, which leads, over time, to feelings of anxiety, depression, especially when they do not benefit from social support and have not developed resilience mechanisms.
Exosomal miR-22-3p from Mesenchymal Stem Cells Inhibits the Epithelial-Mesenchymal Transition (EMT) of Melanoma Cells by Regulating LGALS1
Authors: Chen Yong , Fang Yuan , Li Li , Luo Hui , Cao Tianran , Tu Biao
Published: September 2022

Background: The mortality rate from melanoma has been rising and hence new therapeutic approaches for this disease have received extensive attention, especially the search for novel therapeutic targets. The aim of this study was to find new targets for the treatment of melanoma through a bioinformatics and experimental approach. Methods: First, we screened for differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) between melanoma and normal tissues using the TCGA-SKCM, GTEX, and GSE24996 datasets. Next, we identified epithelial-mesenchymal transition (EMT)-related DEGs and analyzed their expression levels and association with patient survival. The expression level of DEGs was then confirmed in normal human melanocytes and melanoma cells. Bioinformatics analysis was used to identify miRNAs that targeted the most highly expressed DEG, LGALS1, and their binding confirmed using dual luciferase. Enriched pathways for the LGALS1 target miR-22-3p were also analyzed. miR-22-3p was overexpressed in cells in order to investigate changes in cell activity and in related genes and proteins. Exosomes from human bone marrow mesenchymal stem cells (MSCs) were coated with miR-22-3p to examine its effect on EMT. Results: The expression levels of LGALS1, CPXM1, and APLNR were higher in melanoma than in normal tissues and were associated with worse patient survival. The differential expression of these genes was confirmed using normal human skin melanocytes (PIG1) and human melanoma cells (WM-266-4). LGALS1 was the most differentially expressed gene between WM-266-4 and PIG1 cells, and was also predicted to be a target for miR-22-3p. The results of dual luciferase experiments confirmed that miR-22-3p could bind to LGALS1. Following the overexpression of miR-22-3p in WM-266-4 cells, the cell viability decreased, the expression levels of LGALS1, VIM and SNAI2 decreased, the expression level of CDH1 increased, and cell apoptosis increased. Transfection of miR-22-3p using exosomes resulted in similar effects. Conclusions: We identified three genes (LGALS1, CPXM1, APLNR) that showed a high level of differential expression in melanoma. LGALS1 is a target for miR-22-3p binding and this can inhibit the EMT of melanoma cells, thereby preventing the development of melanoma. Moreover, exosomes secreted by MSCs can be loaded with miR-22-3p, thus regulating the EMT process in melanoma cells.
A Behavioral Approach to Treatment and Assessment of People with Disorders of Consciousness: The Response-contingent Stimulation Strategy
Authors: Lancioni Giulio E. , Belardinelli Marta Olivetti , Singh Nirbhay N. , O’Reilly Mark F. , Sigafoos Jeff , Alberti Gloria , Desideri Lorenzo
Published: September 2022

Response-contingent stimulation is a behavioral strategy used to improve the situation of patients with disorders of consciousness. Such strategy involves the presentation of brief periods (e.g., 10 to 15 s) of stimulation considered preferred by the patients, contingent on (immediately after) the emission of specific patients’ responses. The aim is to help the patients learn the link between their responding and the preferred stimulation and thus learn to use their responding to access the stimulation in a self-determined/independent manner. Achieving these goals is considered important for the patients’ recovery process and thus the response-contingent stimulation strategy that promotes such an achievement can be considered a valuable treatment approach. The same strategy combined with the use of periods of non-contingent stimulation (i.e., stimulation delivered independent of responding) may also serve as an assessment supplement with patients with apparent unresponsive wakefulness. The patients’ increase in responding during the response-contingent stimulation and decline in responding during the non-contingent stimulation could be taken as a sign of discrimination between conditions, and possibly a sign of awareness of the immediate environmental situation, compatible with a diagnosis of minimally conscious state. This paper analyzes a number of studies aimed at using the response-contingent stimulation as a treatment strategy and a number of studies aimed at combining response-contingent stimulation with non-contingent stimulation for treatment and assessment purposes. The results of the studies are discussed in terms of the effectiveness, accessibility and affordability of the strategy. The need for new research (i.e., replication studies) is also pointed out.
Bir Başkentin Yansıması, Ankara: Eryılmaz Ailesinin Öyküsü
Authors: PAYNE Geoffrey , ŞAHİNKAYA ÖZER Cemre
Published: September 2022

Türkiye'nin başkenti Ankara, ülkenin büyümesine paralel olarak özellikle 1970'li yıllarda hızlı bir şehirleşme sürecinden geçmiştir. Artan göç ve çoğalan konut ihtiyacı kentin kontrol edilemez biçimde büyümesini tetiklerken, birçok konuda da şehrin kendisini geliştirmesini hızlandırmıştır. Bu yıllarda hızla büyümesi ve gelişmesiyle göze çarpan Ankara, İngiliz akademisyen Geoffrey Payne'in 1974-1975 yılları arasında yürüttüğü kapsamlı bir şehircilik araştırmasına konu olmuştur. Bu çalışma 2019 yılında boylamsal bir yaklaşımla yeniden güncellenmeye başlanmıştır. Bu nedenle, Payne'in çalışmasına Çorum'dan Ankara'ya göç edip Dikmen'de mütevazı bir gecekonduda hayatını sürdürürken konu olan Eryılmaz ailesinin üyeleri ile 2019 yılında tekrar buluşma sağlanmış ve görüşme gerçekleştirilmiştir. Bu buluşmada, Eryılmaz ailesinin farklı kuşaklarıyla biraraya gelinmiş ve ailenin Ankara ile bütünleşerek gelişen ve değişen 50 yıllık yaşam hikayesi, geçmişe ışık tutacak şekilde yarı yapılandırılmış sorularla derinlemesine bir görüşme tekniğiyle irdelenmiştir. Böylelikle kentte yaşayanların kent ile etkileşimleri, yaşanan sosyo-ekonomik değişimler, konut kavramındaki gelişmeler ve kentin yaşayanları üzerindeki yansımaları gerçek bir hikaye üzerinden sunulmuştur. 1974’te başlayan ve 2019 yılından itibaren güncellenerek devam eden bu araştırma Prof. Dr. Ruşen Keleş’in desteği ile sürdürülmüştür.
Avrupa Ülkererinin Haberleşme Sektöründeki Yatırımlarının Matematiksel Modellenmesi
Authors: KARACUHA Kamil , SAĞLAMOL Semih Aslan , ERGÜN Esra , ÖNAL TUĞRUL Nisa Özge , ŞİMŞEK Kevser , KARACUHA Ertugrul
Published: September 2022

This study investigates the amounts of countries’ telecommunication investments and seeks a decent method to mathematically model the data. Using fractional calculus, two methods are proposed which are called model 1 and model 2 in the study. A comparison is performed between the conventional polynomial model and models 1 and 2 using the yearly data of telecommunication investments from France, Germany, Italy, Spain, Turkey, and the OECD total. The proposed methods outperform the conventional polynomial model.
Antioksidan ve Üreaz Enzim İnhibitörü Olarak Siyah Çay İşleme Atığındaki Kateşinleri İçeren Bazı Azo Bileşikleri
Authors: KANTAR Cihan , ER Zeliha , BALTAŞ Nimet , ŞAŞMAZ Selami
Published: September 2022

Although various azo compounds containing some natural origin catechins had been synthesized and determined their dyeing properties for various textile products, azo compounds containing black tea waste catechins and their antioxidant capacity and urease enzyme inhibition were not investigated until this study. The urease enzyme is the most important enzyme that allows the bacteria Helicobacter pylori, which is considered the main factor of stomach cancer, to live in the stomach. Inhibition of this enzyme is very important for the treatment of Helicobacter pylori infection. It has been known that catechin extracts of natural origin inhibit the urease enzyme of Helicobacter pylori from literature. Black tea processing waste is a residue that is separated from the sieves during tea processing and has no economic value. The transformation of this residue into products that produce added value is very important because it contains many chemicals contained in the tea plant.

In this study, some azo compounds containing black tea processing waste catechins were synthesized and investigated their antioxidant capacity, urease enzyme inhibition properties.