bluuebunny/crossref_metadata_2025 huggingface dataset:
Automated and Data-driven Computational Design of Patient-Specific Biomechanical Interfaces
Authors: Moerman Kevin Mattheus , Solav Dana , Sengeh David , Herr Hugh
Published: July 2018

Biomechanical interfaces are mechanical structures that form the connection between a device and a tissue region, and, through appropriate load transfer, aim to minimize tissue discomfort and injury. A patient-specific and data-driven computational framework for the automated design of biomechanical interfaces is presented here. Optimization of the design of biomechanical interfaces is complex since it is affected by the interplay of the geometry and mechanical properties of both the tissue and the interface. The proposed framework is presented for the application of transtibial amputee prostheses where the interface is formed by a prosthetic liner and socket. Conventional socket design and manufacturing is largely artisan, non-standard, and insufficiently data-driven, leading to discrepancies between the quality of sockets produced by different prosthetists. Furthermore, current prosthetic liners are often not patient-specific. The proposed framework involves: A) non-invasive imaging to record patient geometry, B) indentation to assess tissue mechanical properties, C) data-driven and automated creation of patient-specific designs, D) patient-specific finite element analysis (FEA) and design evaluation, and finally E) computer aided manufacturing. Uniquely, the FEA procedure controls both the design and mechanical properties of the devices, and simulates, not only the loading during use, but also the pre-load induced by the donning of both the liner and the socket independently. Through FEA evaluation, detailed information on internal and external tissue loading, which are directly responsible for discomfort and injury, are available. Further, these provide quantitative evidence on the implications of design choices, e.g. : 1) alterations in the design can be used to locally enhance or reduce tissue loading, 2) compliant features can aid in relieving local surface pressure. The proposed methods form a patient-specific, data-driven and repeatable design framework for biomechanical interfaces, and by enabling FEA-based optimization reduces the requirement for repeated patient involvement in the currently manual and iterative design process.
On-line liquid quench sampling and UV-Vis spectroscopy for tar measurements in wood gasification process gases
Authors: Edinger Philip
Published: July 2018

In biomass gasification processes, the formation and handling of tars are of major concern. Robust and versatile analytical tools are needed to on-line monitor tar compound concentrations in process gases from lab- to industrial scale. This study addresses the development and application of an on-line UV-Vis method, based on a liquid quench sampling system. The high sensitivity of this method allows to detect UV-Vis active tar compounds in the low ppmv region. Recorded spectra from the liquid phase were analyzed for their tar composition by means of a classical least squares (CLS) and partial least squares (PLS) approach. The developed method was applied to two case studies, involving a lab-scale tar reformer and a pilot-scale gas scrubber. Quantification results in gases with limited complexity in tar composition showed good agreement with off-line reference methods (GC-FID). The case studies show that the developed method is a rapid, sensitive tool that can be applied for qualitative process monitoring with the added benefit of quantification in gases with a limited number of tar compounds.
Zero mean waveforms for neural stimulation
Authors: Williams Ian
Published: July 2018

Biphasic charge balanced waveforms do not minimise faradaic processes at the electrode-electrolyte boundary and do not leave electrodes neutral with respect to the tissue. Superior waveforms for electrode health (and consequently tissue safety) exist and may also offer better performance in terms of power consumption and stimulation effectiveness within charge injection limits. This paper aims to provide intuitive insight into the limitations of biphasic waveforms and presents a simple method for assessing how well other waveforms will perform, as well as methods for designing waveforms to theoretically give zero residual voltage and zero net faradaic charge transfer.
Precision, repeatability and accuracy of Optotrak® optical motion tracking systems
Authors: Schmidt Jill , Berg Devin R.
Published: July 2018

In the field of biomechanics, optical motion tracking systems are commonly used to record human motion and assist in surgical navigation. Recently, motion tracking systems have been used to track implant and bone motion on a micron-level. The present study evaluated four different Optotrak® motion tracking systems to determine the precision, repeatability and accuracy under static testing conditions. The distance between the camera systems and the rigid body, as well as the tilt angle of the rigid body, did affect the resulting precision, repeatability and accuracy of the camera systems. The precision and repeatability, calculated as the within-trial and between-trial standard deviations, respectively, were less than 30 µm; with some configurations producing precision and repeatability less than 1 µm. The accuracy was less than 0.53% of the total displacement for the in-plane motion and less than 1.56% of the total displacement for the out-of-plane motion.
Mechanical Properties and Microstructural Analysis of 304 Stainless Steel by TIG Welding
Authors: BIN RIDZUAN MUHAMMAD NAZMI HAKIM
Published: July 2018

Gas tungsten arc welding is the process repairing and widely used in heavy engineering for joining metal. It can be uses for various type of metal and application. The aim of this project is to study the effects of 304 stainless steel with 3 mm thickness on mechanical properties and its microstructure analysis towards gas tungsten arc welding method. The variables set up in this project were current, gas flow rate and welding direction upon rolling direction of stainless steel sheet. Three current setup were used which is 60 A, 80 A and 100 A Type of filler metal used in this project was ER 308L with 1.6 diameter. Two set up for gas flow rate were used which is 8 l/m and 12 l/m. Testing that carried out were tensile test, Vickers macro hardness test with 10 kgf load and microstructure analysis by using optical microscope. The effects of microstructure in austenitic stainless steel welds is discussed. From the mechanical properties procedures, the strength of the weld metal was obtain. For hardness testing, the most important zone to be focused were heat-affected zone (HAZ) and weld metal (WM). The integrity of the welding tested by using tensile test and hardness test with different amount of current and gas flow rate.
Data on the Design of Truss Structures by Teams of Engineering Students
Authors: McComb Christopher , Cagan Jonathan , Kotovsky Kenneth
Published: July 2018

This experiment was conducted in order to compare different approaches that human teams use to solve design problems that change dynamically during solving. Specifically, study participants were given the task of designing a truss structure (similar to a bridge spanning a chasm) in teams of three. At two points during design, the problem statement was changed unexpectedly, requiring participants to adapt. Two conditions were given different initial problem representations. During the study, every participant had access to a computer interface that allowed them to construct, test, and share solutions. The interface also made it possible to collect a step-by-step log of the actions made by participants during the study. This article contains data collected from 48 participants (16 teams). This data has been used previously in behavioral analyses, sequence-based analysis, and development of computational models.
Perceived Quality Attributes Framework and Ranking Method.
Authors: Stylidis Konstantinos , Wickman Casper , Söderberg Rikard
Published: July 2018

Perceived quality (PQ) is one of the most important product attributes in the automotive industry that defines successful automotive design. This paper presents a new approach regarding PQ assessment by examining PQ decomposed into a structure with the top-down approach to the level of basic (“ground”) attributes, covering almost every aspect of car quality perception from the engineering viewpoint. The paper proposes a novel method for PQ attributes relative importance ranking, resulting in the PQ balance of the vehicle, within the given conditions. The proposed method helps to reach the equilibrium of the vehicle’s quality equation from the perspective of design effort, time and costs estimations. The authors introduce the Perceived Quality Framework (PQF), which is the taxonomy system for PQ attributes and the core of the attributes importance ranking method. The research outcomes are based on findings of qualitative exploratory study that includes the European and North American premium and luxury automotive manufacturers. To validate the proposed method, an industrial pilot study was performed with one of the automotive companies to examine the PQ attributes importance ranking obtained from automotive industry professionals. The results can significantly improve PQ assessment during all stages of product development.
Flexural Strength and Crack Propagation of Porous Clay- Precipitated Calcium Carbonates
Authors: AZMY NUR ALIA BINTI ROSLIN
Published: July 2018

Porous clay-precipitated calcium carbonates were prepared via polymeric sponge replication method using precipitated calcium carbonates (PCC) and red clay as raw materials. Different compositions of precipitated calcium carbonates (PCC) which is 10 wt.% and 15 wt.% with 24 hours and 48 hours milling time were sintered at 1250°C for 2 hours respectively which influenced the flexural strength and morphology of the porous ceramic. The highest flexural strength (1.843 MPa) were obtained by 10 wt.% [CaCO3]PCC milled at 24 hours related to the lowest percentage of porosity (81.00%). Mineralogical characterization of porous ceramic were determined via X-ray diffraction (XRD) shows the presence of crystalline phases such as anorthite (2CaAl2Si2O8), gehlenite (Ca2Al2SiO7) and esseneite (CaFeAlSiO6) after sintering process. The morphological analysis via stereomicroscope shows that the porosity and struts were found due to presence of precipitated calcium carbonates that act as pore forming agent. The colour of porous ceramic between 10 wt.% [CaCO3]PCC and 15 wt.% [CaCO3]PCC shows significant difference due to iron oxide contained in the red clay which contributes to the colour of the samples. Crack propagates in the intergranular type of fracture mode due to resulted porous ceramic is a brittle material.
The role of hydrogen and fuel cells in the global energy system
Authors: Staffell Iain , Scamman Daniel , Abad Anthony Velazquez , Balcombe Paul , Dodds Paul E. , Ekins Paul , Shah Nilay , Ward Kate R.
Published: July 2018

Hydrogen technologies have experienced cycles of excessive expectations followed by disillusion.Nonetheless, a growing body of evidence suggests these technologies form an attractive option forthe deep decarbonisation of global energy systems, and that recent improvements in their cost andperformance point towards economic viability as well. This paper is a comprehensive review of thepotential role that hydrogen could play in the provision of electricity, heat, industry, transport andenergy storage in a low-carbon energy system, and an assessment of the status of hydrogen in beingable to fulfil that potential. The picture that emerges is one of qualified promise: hydrogen is wellestablished in certain niches such as forklift trucks, while mainstream applications are now forthcoming.Hydrogen vehicles are available commercially in several countries, and 225,000 fuel cell home heatingsystems have been sold. This represents a step change from the situation of only five years ago. Thisreview shows that challenges around cost and performance remain, and considerable improvements arestill required for hydrogen to become truly competitive. But such competitiveness in the medium-termfuture no longer seems an unrealistic prospect, which fully justifies the growing interest and policysupport for these technologies around the world.
Detailed effects of a diesel particulate filter on the reduction of chemical species emissions
Authors: Berg Devin R.
Published: July 2018

Diesel particulate filters are designed to reduce themass emissions of diesel particulate matter and havebeen proven to be effective in this respect. Not much isknown, however, about their effects on otherunregulated chemical species. This study utilized sourcedilution sampling techniques to evaluate the effects of acatalyzed diesel particulate filter on a wide spectrum ofchemical emissions from a heavy-duty diesel engine.The species analyzed included both criteria andunregulated compounds such as particulate matter(PM), carbon monoxide (CO), hydrocarbons (HC),inorganic ions, trace metallic compounds, elemental andorganic carbon (EC and OC), polycyclic aromatichydrocarbons (PAHs), and other organic compounds.Results showed a significant reduction for the emissionsof PM mass, CO, HC, metals, EC, OC, and PAHs.
Malawi Hydro-Generator Project
Authors: Yohnk Garret
Published: July 2018

Malawi Hydro Generator
Soft Tissue Artifact Compensation Using Triangular Cosserat Point Elements (TCPEs)
Authors: Solav Dana , Rubin MB , Wolf Alon
Published: July 2018

Existing methods which compensate for the Soft Tissue Artifact (STA) in optoelectronic motion measurements estimate the rigid motion of a nearly rigid underlying body segment based on analysis of the motion of all fiducial markers. The objective of the proposed Triangular Cosserat Point Elements (TCPE) method is to estimate the motion of the underlying body segment even when the STA in the entire cluster of markers can be large. This is accomplished by characterizing the cluster of markers with TCPEs defined by triangles based on all combinations of three markers. Then, scalar deformation measures characterizing the magnitudes of strain and relative rotation of pairs of TCPEs are defined for each TCPE. These deformation measures are used to define a filtered group of TCPEs which best represents the motion of the underlying body segment. The method was tested using an experimental setup that consists of a rigid pendulum with a deformable 300ml silicone breast implant attached to it as a simulation of the soft tissue around a bony segment. The rotation angles extracted from markers on the deformable implant were compared with simultaneous measurements of the rigid pendulum using an optoelectronic system. Analysis of the experimental data shows that this filtering process substantially reduces the error due to the STA even though the data set includes large deformations. In particular, the analysis shows that the error reduction using the TCPE approach is larger than the reductions obtained using standard least-squares minimization methods.
An experimental framework for determining wear in porous journal bearings operated in the mixed lubrication regime
Authors: Eder Stefan J , Ielchici Christian , Krenn Stefan , Brandtner Daniel
Published: July 2018

We present an experimental and analysis workflow to characterize the tribological behavior and the wear resistance of porous journal bearing systems operating at high loads and small rotational speeds. Our approach consists of a laser-instrumented tribometer that allows parallel testing of five bearings, an experimental procedure that is optimized for producing sufficient wear during mixed lubrication operation while maintaining realistic operating conditions, as well as several methods to visualize and quantify bearing wear. The simultaneous testing of five bearings prevents outliers from distorting the results and yields a statistical estimation of the performance variations between nominally equivalent tribosystems. We showcase our approach by analyzing the influence of the bearing material and its porosity on mixed-lubrication friction and wear.
Chest Wall Kinematics Using Triangular Cosserat Point Elements in Healthy and Neuromuscular Subjects
Authors: Solav Dana , Meric Henri , Rubin MB , Pradon Didier , Lofaso Frédéric , Wolf Alon
Published: July 2018

Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local CW kinematics from OEP measurements based on the kinematics of triangular Cosserat point elements (TCPEs). 52 reflective markers were placed on the anterior CW to create a mesh of 78 triangles according to an anatomical model. Each triangle was characterized by a TCPE and its kinematics was described using four time-variant scalar TCPE parameters. The total CW volume ( VTCW) and the contributions of its six compartments were also estimated, using the same markers. The method was evaluated using measurements of ten healthy subjects, nine patients with Pompe disease, and ten patients with Duchenne muscular dystrophy (DMD), during spontaneous breathing (SB) and vital capacity maneuvers (VC) in the supine position. TCPE parameters and compartmental volumes were compared with VTCW by computing the phase angles θ (for SB) and the correlation r (for VC) between them. Analysis of θ and r of the outward translation parameter PT of each TCPE revealed that for healthy subjects it provided similar results to those obtained by compartmental volumes, whereas for the neuromuscular patients the TCPE method was capable of detecting local asynchronous and paradoxical movements also in cases where they were undistinguished by volumes. Therefore, the TCPE approach provides additional information to OEP that may enhance its clinical evaluation capabilities.
Malawi Drive System
Authors: Harris Matthew
Published: July 2018

A Pelton wheel drive system for a hydroelectric turbine
Adaptive Door Handle
Authors: Tauer Travis
Published: July 2018

ETECH-100 Project.Adaptive door handle for wrist impinged patients.
New considerations about light pollution in rural and protected areas based on a global perspective savings-pollution-safety: Impact on real installations
Authors: Peña-García Antonio , Sędziwy Adam
Published: July 2018

The broad implementation of LED light sources in public lighting has become arevolution in the last years. Their low power consumption and good performance makeLED an optimal solution in most of outdoor applications. In addition, the white lightemitted by the vast majority of the LED used in public lighting and their good colorrendering allow pedestrians and drivers enjoy of more comfortable cities at night,especially commercial zones and city centre. However, the regulations on lightpollution, that in some countries have been developed in parallel to the introduction ofLED lighting, present strong constrains to white light due to Rayleigh scattering. Theseregulations request filtering of blue wavelengths in some rural areas, and thus they limitthe projects to high pressure sodium sources or amber LEDs, whose prices are higherand performances lower than for white LEDs. In this work, the pros and contras ofwhite and amber LED lighting in rural areas are analyzed and compared through realsimulations and considerations based on efficiency and light pollution. Importantconclusions for installations in rural and protected areas are presented.
Selection of Artificial Muscle Actuators for a Continuum Manipulator
Authors: Berg Devin R. , Li Perry Y. , Erdman Arthur G.
Published: July 2018

Artificial muscle actuators have become a popular choice as actuation units for robotic applications, particularly in the growing area of soft robotics. The precise specification of an artificial muscle actuator for a particular application requires the consideration of several parameters that work together to achieve the performance characteristics of the actuator. This paper explores the specification of artificial muscle actuator parameters by presenting and applying the analytical description of the actuator, simulation by finite element method for investigating material stresses under a wide variety of configurations, and a specific parameter selection process. This is followed by an experimental validation using an example actuator to compare against the predicted actuator performance. Some discussion of appropriateness of this type of actuator as a candidate solution for use in the example application of a dexterous continuum manipulator is included.This work has been submitted to the IEEE for possible publication.
Capturing Human Sequence-Learning Abilities in Configuration Design Tasks through Markov Chains
Authors: McComb Christopher , Kotovsky Kenneth , Cagan Jonathan
Published: July 2018

Designers often search for new solutions by iteratively adapting a current design. By engaging in this search, designers not only improve solution quality but also begin to learn what operational patterns might improve the solution in future iterations. Previous work in psychology has demonstrated that humans can fluently and adeptly learn short operational sequences that aid problem-solving. This paper explores how designers learn and employ sequences within the realm of engineering design. Specifically, this work analyzes behavioral patterns in two human studies in which participants solved configuration design problems. Behavioral data from the two studies are first analyzed using Markov chains to determine how much representation complexity is necessary to quantify the sequential patterns that designers employ during solving. It is discovered that first-order Markov chains are capable of accurately representing designers' sequences. Next, the ability to learn first-order sequences is implemented in an agent-based modeling framework to assess the performance implications of sequence-learning abilities. These computational studies confirm the assumption that the ability to learn sequences is beneficial to designers.
Hypoxia-directed Magnetic Resonance-guided Focused Ultrasound Therapy
Authors: Griffin Robert , Chen Xin
Published: July 2018

Compelling clinical and experimental evidence clearly indicates that tumor hypoxia remains a challenge for radiation and chemotherapy. The general consensus is that tumor hypoxia is a major cause of treatment failures. We therefore hypothesize that it would be beneficial to detect the hypoxic areas in tumors and irreversibly ablate them to reduce hypoxia related resistance. To test this hypothesis, we propose preclinical studies using a mouse tumor model and PET/MRI guidance to thermally ablate hypoxic-tissue prior to ionizing radiation. In humans, this approach may significantly shorten focused ultrasound thermal ablation treatment times since only hypoxic regions of tumors are targeted.
MR Directed Focal Hyperthermia for Pelvic Disease
Authors: Diederich Chris J , Tognina Viola , Ozhinsky Eugene , Kurhanewicz John , Hsu I.C. Joe
Published: July 2018

In order to facilitate clinical studies of MR guided hyperthermia in the prostate (and pelvis), we plan to devise and implement modifications of controlling systems to the InSightec ExAblate 2100 Prostate System to allow protracted hyperthermia delivery under multi-slice or volumetric MR thermal guidance. Treatment strategies will be developed and assessed using advanced patient specific modeling studies. The modified endorectal ablation system will be evaluated for delivery of hyperthermia in ex vivo tissue and phantom, and perfused tissue in vivo. The results of this study will provide data supporting an IDE application & techniques for applying clinical studies of MR guided hyperthermia within pelvic disease sites. This MR guided approach for administering targeted and protracted (vs. pulsed) hyperthermia to prostate, and possibly other pelvic sites such as cervix and rectum, has potential to significantly enhance efficacy of drug delivery, immunotherapy, and/or hypofractionated radiation therapy
MR Guided Pulsed High Intensity Focused Ultrasound Enhancement of Docetaxel Combined with Radiotherapy for Prostate Cancer Treatment
Authors: Chen Lili , Pollack Alan
Published: July 2018

This project will determine whether (1) HIFU increases the cellular update of docetaxel in vivo, and (2) the increased uptake of docetaxel combined with RT will enhance tumor growth inhibition. We will determine the optimal HIFU parameters, quantify the update of docetaxel using a radioactive tritiated docetaxel and evaluate the efficacy of docetaxel+RT in inhibiting prostate tumor growth in vivo. This research has the potential to improve local control and may also have effects on distant microscopic disease by promoting immune response, which will also lay the foundation for other tumor models and studies on gene therapy and thrombolytic drugs.
MR-Guided High Intensity Focused Ultrasound -- Temperature Measurement
Authors: Parker Dennis L , Todd Nick , Wang Yi , Coon Josh
Published: July 2018

Accurate, near-real-time temperature measurements are essential for effective monitoring of all types of thermal therapies. Current methods are too slow, subject to substantial errors from motion and fail in fat. We propose: 1) To develop a modification of the PRF technique to allow simultaneous measurement of proton longitudinal relaxation rate, T1. 2) To continue the implementation of model-based linear predictive techniques to utilize the best estimate of tissue thermal properties and linear predictive filtering (e.g., Kalman filter) to obtain the current estimate of the temperature distribution from the prior temperature distribution. Tissue thermal properties will be estimated based upon segmentation from multiple MRI contrasts.
Delivery of Brain Tumor-Penetrating Nanoparticles Across the Blood Brain Barrier with MR-Guided Focused Ultrasound
Authors: Price Richard J.
Published: July 2018

Glioblastoma multiforme (GBM) has a 5-year survival rate of only 12%, due primarily to the inability of chemotherapeutic drugs to cross the blood brain barrier (BBB). The goal of this proposal is to improve GBM therapy by coupling MR-guided BBB opening via focused ultrasound (FUS) and microbubbles (MBs) with drug-loaded nanoparticles that efficiently penetrate brain tissue. Here, we will first define FUS pressure thresholds for safe and reversible BBB opening to an MR contrast agent (gadolinium) in invasive intracranial brain tumors. Next, we will determine optimal conditions for delivering brain penetrating nanoparticle (BPN) formulations. Once completed, these studies will have provided the foundation for future studies in which therapeutic BPNs are delivered across the BBB to inhibit tumor growth and improve animal survival.
Nanoagents for improving focused ultrasound thermal delivery to tumors with imaging feedback
Authors: Dayton Paul
Published: July 2018

We have developed a unique metastable nanodroplet formulation which data suggests 1) will improve thermal delivery efficiency of intensity focused ultrasound (HIFU) ablation in vivo, and 2) will improve the spatial distribution of thermal delivery at the acoustic focus, without near-field attenuation or heating. In this project, we will test and optimize our approach by quantifying nanodroplet dose and improvements in thermal delivery efficiency in vivo using MRgFUS; assessing long term circulation in vivo; and by performing MRgFUS in vivo studies in rodent tumor model to validate nanodropletenhanced HIFU treatment of tumors, compared to sham controls. Finally, we will perform histology to assess tissue for collateral bioeffects.
Image-guided Non-invasive Ultrasonic Thrombolysis Using Histotripsy
Authors: Xu Zhen
Published: July 2018

Deep vein thrombosis (DVT), clot formation in the deep veins in the legs, affects two million Americans annually. Clinical DVT treatments include thrombolytic drugs and catheter-based surgical procedures. Both methods have significant drawbacks, such as excessive bleeding and invasiveness. Guided by ultrasound imaging, histotripsy is a non-invasive cavitation-based ultrasound therapy that fractionates tissue. Using our laboratory prototype, histotripsy fractionated in vitro clots into debris smaller than red blood cells at a speed an order of magnitude faster than clinical thrombolysis methods. Using an in vivo porcine DVT model, histotripsy non-invasively eradicated the thrombus in 10 of 12 cases. We have designed and constructed an integrated ultrasound image-guided histotripsy thrombolysis system based on human DVT patient data. We propose a comprehensive pre-clinical study to determine the safety and efficacy of this clinically designed histotripsy system in a porcine DVT model. The proposed study is critical to advancing the clinical translation of this new technology to improve the standard of care for DVT patients.
EAP-FUS022 (Yoo): FUS Mediated Reversible Modulation of Region Specific Brain Function
Authors: Yoo Seung-Schik , Lee Jong-Hwan , Zhang Yongzhi , Lee Wonhye , Fischer Krisztina , Golby Alexandra , McDannold Nathan , Jolesz Ferenc
Published: July 2018

The goal of the proposed research is to investigate the feasibility of using low-intensity and lowfrequency focused ultrasound energy to reversibly modulate the activity of a region-specific brain area. We will modulate the cortical activity from an animal brain using FUS sonication, as monitored by real-time functional MRI. Prior to the animal experiment, in-vitro phantoms containing neural cells will be constructed and sonicated to estimate the range of suitable sonication parameters. This work is expected to provide an unprecedented opportunity for the transient functional modulation of targeted brain regions, creating a new line of applications, such as FUS-mediated functional mapping.
Enhancement of FUS Mediated Delivery of Stem Cells to Brain
Authors: Fishman Paul S.
Published: July 2018

We propose that magnetic targeting of super-paramagnetic iron oxide nanoparticles (SPION) labeled cells will enhance the delivery of stem cells to brain after focused ultrasound (FUS) mediated opening of the blood-brain barrier (BBB). FUS mediated opening of the BBB allowing stem cells to enter the brain from the blood is a remarkable advance in delivery of stem cell therapeutics over current invasive methods of brain injection. However the efficiency of cellular entry is low. SPIONs are taken up by stem cells, allowing for labeling of transplanted stem cells in brain both with histology and MRI. Our research shows that SPION labeled stem cells show enhanced brain retention near a magnet on the skull, in a rat model of traumatic brain injury. There is no experience combining these two minimally invasive strategies to deliver stem cells to the brain. We will assess the capacity of an external magnet to enhance the efficiency of delivery to brain of SPION loaded stem cells after transient opening of the BBB using FUS. We will evaluate SPION loaded neural stem cells delivered by intravenous infusion in rats that have undergone MRI targeted FUS opening of the BBB along with a magnet placed over the skull of the sonicated hemisphere, to animals with FUS alone. The number and distribution of stem cells will be quantitative for each group to assess enhancement of delivery of stem cells after BBB opening using FUS by the addition of SPION loading and an external magnet.
Trans-Esophageal Cardiac Ablation Using High Intensity Focused Ultrasound: A New Minimally Invasive Therapy for Treating Arrhythmias
Authors: Lafon Cyril , Greillier Paul
Published: July 2018

Our research project at LabTau aims at developing a probe capable of delivering HIFU into the heart by a trans oesophageal approach for treating cardiac arrhythmia. Anatomical guidance is achieved with B-mode ultrasound imaging. The goal of the present study is to generate thermal lesion on beating heart of primate, where arrhythmia foci are present in humans, in order to prove the feasibility of the approach. Treatments will be monitored in real time with conventional and passive ultrafast elastography, and then with MRI. This original strategy for treating arrhythmia would avoid invasive insertion of catheter into the heart.
PENINGKATAN KOMPETENSI GURU MATEMATIKA SMK DI SIDOARJO MELALUI APLIKASI GEOGEBRA
Authors: Muharlisiani Lusy Tunik , Anam Fatkul , Emanuel Endrayana Putut Laksminto , Dr Heni Sukrisno M. Pd
Published: July 2018

Perkembangan teknologi yang pesat membuka peluang dan jalan baru dalam mengerjakan banyak hal, termasuk untuk mengembangkan dunia pendidikan. Saat ini telah banyak berkembang berbagai teknologi yang dapat dimanfaatkan untuk mengembangkan dunia pendidikan, termasuk untuk menunjang pembelajaran matematika, yakni sebagai media pembelajaran matematika, salah satu media pembelajaran yang saat ini telah berkembang demikian pesat adalah komputer dengan berbagai program-program yang relevan. Salah satu program komputer yang dapat dimanfaatkan sebagai media pembelajaran matematika adalah program GeoGebra. Dengan beragam fasiltas yang dimiliki, GeoGebra dapat dimanfaatkan sebagai media pembelajaran matematika untuk mendemonstrasikan atau memvisualisasikan konsep-konsep matematis serta sebagai alat bantu untuk mengkonstruksi konsep-konsep matematis. Dalam rangka melaksanakan pembelajaran yang kreatif dan menyenangkan serta membantu memvisualisasikan konsep-konsep matematis, kepada mitra akan diberikan pelatihan pembelajaran dengan menggunakan GeoGebra, yang didalamnya mencakup pula pembelajaran matematika untuk siswa SMK Plus Nahdlatul Ulama Sidoarjo dan SMK Diponegoro Sidoarjo. Selain itu dilakukan pendampingan kepada mitra, agar upaya melaksanakan pembelajaran yang aktif, kreatif, dan menyenangkan dapat terwujud dan berjalan dengan baik. Luaran yang diharapkan dapat terwujud dari kegiatan ini adalah: (1) Merancang pembelajaran matematika menggunakan GeoGebra, (2) Penggunaan GeoGebra sebagai media dalam pembelajaran matematika, dan (3) Peningkatan kompetensi guru matematika SMK Plus Nahdlatul Ulama Sidoarjo dan SMK Diponegoro Sidoarjo dalam pembelajaran menggunakan GeoGebra.
The Quality of Samama Rotary Cut Veneer
Authors: Cahyono Tekat Dwi , Wahyudi  , Priadi Trisna , Febrianto Fauzi , Novriyanti Eka , Darmawan Wayan , Ohorella Syarif
Published: July 2018

Lathe check on veneer is formed as wood response to peeling process, which is usually analyzed in green veneer. After the veneer passed through drying process, the tendency of lathe check rises due to another factor and then it properly named as veneer check. This study was carried out to analyze lathe check and veneer check of samama. The fresh 8 year old samama log was peeled with the thickness of 1.5 mm and 3.0 mm subsequently after pretreatment of boiling in 50˚C for 4 hours and no boiling treatment as the control. Several 2-centimeter wide segmentations were noted from pith to bark and the resulted veneer of each segment was analyzed to determine the quality of lathe check and veneer check. The result showed that the total of peel crack (lathe check) declined from pith toward bark. The thicker veneer produced more lathe checks than the thinner veneer. Whereas, the depth and length of lathe check showed the same tendency as the total lathe check, which showed reduction toward bark’s segmentation. Boiling pretreatment in 50˚C for 4 hours before peeling process tended to increase the quality of samama wood veneer. It was indicated by decreasing in total, length, and depth of lathe checks. Further, it was found that veneer check increased by 19.42-24.94% in comparison to the lathe check. Therefore, the result of this research can be used as consideration in veneer production process of samama including handling and drying, so the quality of the veneer is well sustained.
UTAUT Model: Suatu Pendekatan Evaluasi Penerimaan E-Learning pada Program Pascasarjana
Authors: Mahande Ridwan Daud
Published: July 2018

Kualitas implementasi e-learning akan selalu berhubungan dengan penerimaan pengguna secara sukarela. Sejauhmana penerimaan pengguna terhadap e-learning memerlukan suatu pendekatan evaluasi yang mampu menyelidiki faktor-faktor penentu penerimaan e-learning. Model unified theory of acceptance and use of technology (UTAUT) adalah sintesis model penerimaan teknologi yang akan tepat digunakan sebagai model evaluasi e-learning. Model evaluasi penerimaan e-learning akan menekankan pada empat kunci konstruk dari UTAUT, yaitu: harapan kinerja, harapan usaha, pengaruh sosial, dan kondisi fasilitas terhadap niat untuk menerima e-learning. Studi ini merupakan studi awal yang diharapkan dapat menjadi acuan dalam perumusan kebijakan mengenai implementasi dan pengembangan e-learning yang berkelanjutan pada program pascasarjana
IDENTIFIKASI FUNCTIONAL SKILLS MATHEMATICS MAHASISWA TEKNIK INFORMATIKA DALAM PROSES PEMECAHAN MASALAH
Authors: Oktaviyanthi Rina , AGUS RIA NOVIANA , Supriani Yani
Published: July 2018

Functional skills mathematics (kemampuan dasar matematik) merupakan salah satu aspek dari tiga kemampuan dasar yang diperlukan individu dalam kehidupan, selain bahasa Inggris dan ICT. Kualifikasi kemampuan dasar matematik pada individu menilai tiga proses yang saling berhubungan yaitu representing, analysing, dan interpreting. Ketiga kualifikasi tersebut diidentifikasi dalam proses pemecahan masalah yang dilakukan mahasiswa. Penelitian ini merupakan studi pendahuluan terkait implementasi bahan ajar dari suatu pendekatan pembelajaran yang mendukung pengoptimalan kemampuan dasar matematik mahasiswa. Tujuan studi ini adalah untuk mendapatkan gambaran nyata secara kuantitatif mengenai kemampuan dasar matematik mahasiswa Jurusan Teknik Informatika di lingkungan Universitas Serang Raya. Sebanyak 50 mahasiswa dari total 320 mahasiswa berpartisipasi menjadi sampel penelitian. Adapun metode penelitian yang digunakan adalah deskriptif analitis melalui proses mendeskripsikan, menuturkan, menafsirkan, dan menganalisis data. Teknik pengumpulan data dilakukan melalui tes kemampuan dasar matematik, pengisian kuisioner, dan wawancara. Dari hasil pengolahan data diperoleh 10 mahasiswa pada level kemampuan dasar matematik tinggi 90% menguasai representing, 70% analysing, dan 50% interpreting. Kelompok mahasiswa pada level kemampuan dasar matematik sedang sebanyak 18 orang, keseluruhannya menguasai representing, 44,4% analysing, dan 27,8% interpreting. Sementara dari 22 mahasiswa dengan kemampuan dasar matematik rendah, 81,8% menguasai representing, 31,8% analysing, dan hanya 9,1% dalam hal interpreting. Kesimpulan sementara yang dapat diambil dari studi pendahuluan ini adalah bahwa kemampuan dasar matematik 50 mahasiswa pada kualifikasi analysing dan interpreting, khususnya mahasiswa di level kemampuan dasar matematik sedang dan rendah, masih di bawah 50%. Hal ini yang menjadi acuan dasar tim peneliti untuk melanjutkan studi pada kajian yang lebih luas mengenai pengoptimalan kemampuan dasar matematik mahasiswa Jurusan Teknik Informatika dengan mengimplementasikan suatu bahan ajar atau pendekatan tertentu yang sesuai.(This article has been presented in "Seminar Nasional Matematika dan Pendidikan Matematika (SNMPM) 2016", Universitas Swadaya Gunung Jati (UNSWAGATI), Cirebon, Indonesia, February 6, 2016 and has been printed published in Prosiding Seminar Nasional Matematika dan Pendidikan Matematika 2016)
EFEKTIVITAS PENAMBAHAN ASAP CAIR TERHADAP MUTU BAKSO IKAN KAMBING-KAMBING (Abalistes stellaris)
Authors: 2017 Seminar Nasional Multidisiplin Ilmu , AGS Dwi Apriliani
Published: July 2018

Bakso ikan merupakan salah satu olahan yang digemari oleh masyarakat. Kelemahan dari bakso ikan adalah cepat mengalami kemunduran mutu yang disebabkan oleh pertumbuhan bakteri pembusuk selama masa simpan. Asap cair merupakan salah satu pengawet alami yang berfungsi sebagai penghambat pertumbuhan bakteri. Penyimpanan dengan suhu dingin dilakukan untuk menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui efektivitas penambahan asap cair terhadap mutu bakso ikan kambing-kambing (Abalistes stellaris) dengan pengujian Angka Lempeng Total dan Salmonella, dengan konsentrasi penambahan asap 1%, 3%, dan 5% serta lama penyimpanan 0, 10, 20, 30 hari. Hasil penelitian menunjukkan bahwa penambahan asap cair 1%, 3% dan 5% memberikan pengaruh yang berbeda nyata terhadap ALT (p> 0,05) dan tidak berbeda nyata terhadap Salmonella (p<0,05). Jumlah ALT selama penyimpanan 0, 10, 20, dan 30 hari pada bakso ikan penambahan asap cair 1% sebesar 2,0 x 102; 1,85 x 103; 4,08 x 103 dan 4,3 x 104, asap cair 3% sebesar 1,5 x 102; 4,3 x 102; 10 x 103 dan 1,8 x 104, asap cair 5% sebesar 28; 7,5 x 101; 2,6 x 102 dan 4,0 x 103. Hasil uji Salmonella hari ke 0,10, 20, 30 dengan penambahan asap cair 1%, 3% dan 5% adalah negatif.
MANAJEMEN ARSIP PERGURUAN TINGGI: SEBUAH ANALISA SWOT
Authors: Setiawan David , Hakim Triono Dul
Published: July 2018

Perguruan Tinggi pada hakikatnya memiliki tiga misi yakni, pendidikan , penelitian dan pengabdian. Dalam melakukakan ketiga aktivitas ini diakhir kegiatannya akan menghasilkan dokumen, yang kemudian dikumpulkan menjadi arsip. Untuk pengelolaan dokumen tersebut sudah diamanatkan dalam UndangUndang Nomor 43 tahun 2009 tentang kearsipan. Tulisan ini membahas analisa SWOT panerapan manajemen arsip pada perguruan tinggi dengan menggunakan metode analisa deskriptif.Tujuan akhir dari tulisan ini adalah untuk melihat titik lemah perguruan tinggi dalam pengelolaan arsip dan memberikan rekomendasi untuk perbaikan dimasa mendatang.
PENGARUH APLIKASI PUPUK SP 36 TERHADAP PERTUMBUHAN DAN PRODUKSI JAGUNG MANIS (Zea mays saccharata Sturt )
Authors: 2017 Seminar Nasional Multidisiplin Ilmu
Published: July 2018

Penelitian ini dilaksanakan di Desa Sei Dadap 3/4, Kecamatan Sei Dadap, Kabupaten Asahan, Provinsi Sumatera Utara dengan ketinggian ± 10 m dpl, tipe iklim C (oldeman), jarak dari kampus UNA 7 km. Penelitian ini dilaksanakan bulan Juni sampai bulan September 2017.Rancangan penelitian adalah Rancangan Acak Kelompok (RAK) Faktorial Non Faktor yang terdiri dari 4 taraf pemberian pupuk SP-36 yaitu : P1 = 200 kg SP-36/ha (32 g/plot), P2 = 400 kg SP-36/ha (63 g/plot), P3 = 600 kg SP-36/ha (95 g/plot), P4 = 800 kg SP-36/ha (126 g/plot). Dengan 3 ulangan. Pemberian pupuk SP-36 sampai dosis 800 kg SP-36/ha (126 g/plot) (P4) pada tanaman jagung manis menunjukkan adanya pengaruh terhadap peningkatan pertumbuhan tinggi tanaman umur 2 dan 6 MST; diameter batang umur 2, 4 dan 6 MST; luas daun, umur berbunga, produksi jagung berkelobot per sampel.
budaya organisasi
Authors: Dewi Lies Kumara
Published: July 2018

budaya organisasi dan kompetensi
RANCANG BANGUN AERATOR MENGGUNAKAN PENGGERAK MOTOR SATU FASA DAN SISTEM OTOMATISASI BERBASIS SMART RELAY
Authors: Asraf Abdul Gafar , Hasyim Rosma Iswadi
Published: July 2018

Aerator is an equipment that serves to produce oxygen through the diffusion process for the needs of living creatures in the water. Currently, aerators used by the public are still operated manually. Therefore, this article introduces the use of smart relay to control the operational aspect of aerator. The aerator used in this article is double turbine type with each turbine has 6 blades. The automation system was implemented by using smart relay. This smart relay has 2 inputs, namely light sensor and temperature sensor that have very strong correlation with the availability of dissolved oxygen in the water. It has been found that dissolved oxygen is high (30 mg/L) when light intensity > 100,000 lux and the temperature < 350 C. The result was then used as a decision maker for smart relay to control the operation of aerator. The results show that the aerator can work as expected to increase the dissolved oxygen from 8 mg/L - 14.4 mg/L in 45 minutes.
POTENSI PENAMBAHAN DOLOMIT DAN BOTTOM ASH TERHADAP PENINGKATAN NILAI CBR TANAH EKSPANSIF
Authors: 2017 Seminar Nasional Multidisiplin Ilmu , Panjaitan Surta Ria Nurliana
Published: July 2018

Tanah ekspansif adalah tanah lempung mengembang yang mengalami perubahan volume akibat perubahan kadar air dalam tanah. Bentonit merupakan tanah lempung ekspansif yang memiliki daya dukung rendah dan kembang susut yang tinggi. Oleh karena itu maka perlu dilakukan stabilisasi agar nilai CBR menjadi lebih baik sehingga dapat digunakan sebagai tanah dasar dalam suatu kontruksi. Tanah lempung yang digunakan pada penelitian ini yaitu Bentonit yang mengandung mineral smektit (struktur lembaran), yaitu montmorillonit yang bersifat plastis tinggi yang tergolong kepada tanah lempung ekspansif. Pengujian yang dilakukan meliputi pengujian pendahuluan untuk mendapatkan sifat fisis dan nilai CBR dari bentonit serta pengujian lanjutan dengan melakukan stabilisasi dengan dolomit dan bottom ash. Pengujian ini berpedoman pada ASTM untuk setiap pengujian. Kadar dolomit dan bottom ash yang digunakan 3%, 6%, 9%, 12%, dan 15% dari berat kering tanah lempung bentonit, dengan pengujian batas plastis, batas cair, batas susut, indeks plastis, spectivic gravity, sieve analisis, pemadatan dengan standar proctor dan CBR tidak direnda (unsoaked). Hasil penelitian yang dilakukan akan menunjukkan bahwa dengan penambahan dolomit dan bottom ash pada Bentonit (tanah lempung ekspansif) dapat menurunkan sifat fisis dan meningkatkan sifat mekanis tanah, yaitu terjadinya penurunan pada indeks plastisitas dan peningkatan nilai CBR tanah ekspansif
MULTISENSOR DATA FUSION USING MULTIRESOLUSION ANALYSIS (MRA)
Authors: Wikantika Ketut
Published: July 2018

The objective of this study is to propose multiresolution data fusion scheme using multiresolution analysis (MRA). Three techniques compared, respectively based on Haar wavelet basis (HWB), Daubechies wavelet basis (DWB), and IHS transform. Daubechies Wavelet Basis (DWB) is far more efficient than the HWB and IHS transform, thus establishing the advantages for data fusion of formally multiresolution analysis. DWB is best image sharpening and maintain the information of original data. Especially, Daubechies wavelet basis is able to enhance image sharpenin g and preserve spectral information. It has showed the potential application of wavelet transform for higher efficiency for merging spatial and spectral characteristics of multiresolution data.
PENGANTAR PERBANDINGAN SISTEM HUKUM
Authors: Subardjo
Published: July 2018

Pemahaman terhadap berbagai sistem hukum semakin memegang peranan penting. Hal ini sebagai konsekuensi yang tidak dapat dihindari, mengingat interaksi antar bangsa yang semakin intensif baik hubungan yang bersifat privat maupun publik yang di dalamnya diperlukan aturan main yang didasarkan pada suatu makna hukum (legal norm) tertentu yang sangat dipengaruhi oleh sistem hukum masing-masing negara.Dengan demikian memahami berbagai sistem hukum dan budaya hukum yang ada dewasa ini merupakan persoalan yang semakin urgen dalam pergualan antar bangsa yang semakin menggelobal. Adapun harapan serta manfaat dari pembelajaran sistem hukum paling tidak dapat memahami sistem hukum asing dan juga sistem hukum negara kita sendiri, yang pada akhirnya dapat memahami bagaimana menentukan arah pembangunan hukum nasional yang responsif terhadap instrumen-instrumen hukum asing, namun tidak meninggalkan budaya hukum yang hidup berkembang dalam masyarakat.