bluuebunny/crossref_metadata_2025 huggingface dataset:
Vegetables and their by-products: total phenolic compound content, total flavonoids, and antioxidant activity
Authors: Gomes Luiza M , Freitas Alana MR , Dias Tiago , Cavalcante Rodrigo BM
Published: February 2023

ABSTRACT There is an underutilization of bioactive compounds, given the losses and daily waste of vegetables throughout the entire production chain. Accordingly, the objective of this study was to quantify the content of phenolic compounds and antioxidant capacity in different parts of vegetables. Analyzes were performed on five vegetables (zucchini, eggplant, broccoli, green cabbage and green beans) from conventional cultivation. The levels of total phenolics, total flavonoids, and antioxidant capacity were obtained by spectrophotometric methods. Except broccoli, the analyzed by-products had levels of bioactive compounds and antioxidant capacity equal to or greater than the traditional parts of vegetable. Broccoli florets stood out with the highest levels of total phenolics (141.22 mg GAE/100 g), total flavonoids (137.38 mg CE/100 g) and antioxidant capacity (588.3 µmol TEAC/100 g). In contrast, the lowest levels were observed in zucchini pulp (25.44 mg GAE/100 g; 13.03 mg CE/100 g; 69.78 µmol TEAC/100 g). Therefore, the importance of full consumption of vegetables is reiterated. By-products can also be used to enrich preparations.
ANÁLISE DOS IMPACTOS DA DISCIPLINA "ED 707 – DESENVOLVIMENTO E APRENDIZAGEM" NOS DISCENTES
Authors: Leite Sérgio Antônio da Silva , Gasparini Isabella Leão , Dias Natália
Published: February 2023

A dimensão afetiva na mediação pedagógica tem sido objeto de estudo na área educacional desde o final dos anos 90 do século passado. Tendo como base os pressupostos de Vygotsky e Wallon, o presente artigo tem como objetivo investigar os impactos da disciplina ED707 “Desenvolvimento e Aprendizagem”, ofertada no Programa de Pós Graduação da FE/Unicamp desde 1988, em discentes que a cursaram. A metodologia constitui-se por análise documental, questionários e entrevistas. Os dados sugerem que as experiências vivenciadas produziram notáveis impactos na história de vida dos alunos, o que pode explicar a oferta contínua da referida disciplina.
Pathogenicity of Human Anti-PLA2R1 Antibodies in Minipigs: A Pilot Study
Authors: Reinhard Linda , Wiech Thorsten , Reitmeier Aline , Lassé Moritz , Machalitza Maya , Heumann Asmus , Ferru Nicoletta , Loreth Desiree , Schröder Marie-Luise , Hutzfeldt Arvid , Stahl Felix R. , Peine Sven , Gröne Hermann-Josef , Meyer-Schwesinger Catherine , Rinschen Markus M. , Stahl Rolf A.K. , Hoxha Elion
Published: February 2023

Significance Statement

Membranous nephropathy (MN) is an autoimmune kidney disease characterized by immune deposits in the glomerular basement membrane. Circulating anti-phospholipase A2 receptor 1 (PLA2R1) antibodies are detectable in 70%–80% of patients with MN, but experimental evidence of pathogenicity has been lacking. This study demonstrates the pathogenicity of human anti-PLA2R1 antibodies in minipigs, a model for MN that intrinsically expresses PLA2R1 on podocytes. After passive transfer of human anti-PLA2R1 antibody-containing plasma from patients with PLA2R1-associated MN to minipigs, antibodies were detected in the minipig glomeruli, but not in response to plasma from healthy controls. The minipigs developed histomorphological characteristics of MN, local complement activation in the glomeruli, and low-level proteinuria within 7 days, showing that human anti-PLA2R1 antibodies are pathogenic.

Background

Primary membranous nephropathy (MN) is an autoimmune kidney disease in which immune complexes are deposited beneath the epithelium in the glomeruli. The condition introduces a high risk for end-stage kidney disease. Seventy percent to 80% of patients with MN have circulating antibodies against phospholipase A2 receptor 1 (PLA2R1), and levels correlate with treatment response and prognosis. However, experimental evidence that human anti-PLA2R1 antibodies induce MN has been elusive.

Methods

In passive transfer experiments, minipigs received plasma or purified IgG from patients with PLA2R1-associated MN or from healthy controls. Anti-PLA2R1 antibodies and proteinuria were monitored using Western blot, ELISA, and Coomassie staining. Kidney tissues were analyzed using immunohistochemistry, immunofluorescence, electron microscopy, and proteomic analyses.

Results

Minipigs, like humans, express PLA2R1 on podocytes. Human anti-PLA2R1 antibodies bound to minipig PLA2R1 in vitro and in vivo. Passive transfer of human anti-PLA2R1 antibodies from patients with PLA2R1-associated MN to minipigs led to histological characteristics of human early-stage MN, activation of components of the complement cascade, and low levels of proteinuria. We observed development of an autologous, later phase of disease.

Conclusions

A translational approach from humans to minipigs showed that human anti-PLA2R1 antibodies are pathogenic in MN, although in the heterologous phase of disease only low-level proteinuria developed.
Imortais: um estudo de produções midiáticas contemporâneas sobre morte e morrer
Authors: Caldas Simone , Rauber Letícia
Published: February 2023

Este trabalho objetivou compreender as formas como a morte é produzida no meio midiático, identificar mudanças na forma de lidar com a morte na sociedade ocidental e analisar as relações entre a produção da morte com o modelo capitalista. Caracteriza-se como uma pesquisa qualitativa e exploratória de análise documental, cuja coleta de dados ocorreu em site de notícias online da região central do Rio Grande do Sul. A interpretação foi realizada a partir do referencial da psicanálise, aliando os achados com o referencial bibliográfico acerca da temática da morte e morrer. Dentre os resultados, observou-se que a mídia jornalística expressa a forma contemporânea de lidar com o fenômeno da morte na sociedade ocidental. A produção da morte nas redes é uma morte estética, diluída em meio às informações, banalizada e pronta para o consumo. O presente estudo aliou a investigação da produção da morte na mídia com o referencial psicanalítico para lançar luz sobre novas possibilidades de pensar a morte e o morrer no contemporâneo e refletir acerca das formas como lidamos com a morte na mídia.
Amor e relacionamentos amorosos: Estado da arte da produção científica brasileira, de 2013 a 2020
Authors: Oliveira Karine de , Schlösser Adriano
Published: February 2023

O amor e os relacionamentos amorosos se constituem atualmente com fenômenos de intenso interesse e problematização para a ciência psicológica, perpassando desde a esfera clínica até as práticas em pesquisa no campo da atração interpessoal. O objetivo desde estudo foi identificar o estado da arte das produções brasileiras no campo da psicologia do amor e relacionamentos amorosos, nos períodos entre 2013 a 2020. Metodologicamente, foram consultadas as bases de dados ScIELO, LILACS e PePSIC, por meio dos descritores "relacionamentos amorosos" ou "amor". A partir dos critérios de inclusão e exclusão, foram analisados na íntegra 94 produções, 29 teóricos e 65 empíricos. Observou-se uma pluralidade multimetodológica e temática, juntamente com diferentes estratégias de coleta de análise de dados, fortalecendo resultados de pesquisas com características similares, com metodologias diferentes. Atualizando revisões anteriores, os resultados sustentam que o tema está em franco desenvolvimento no país, com dados cada vez mais robustos, fortalecendo a área da pesquisa no cenário brasileiro.
Narrativas biográficas e identidade biker custom
Authors: Oltramari Leandro Castro , Naujorks Carlos José
Published: February 2023

Este estudo aborda as narrativas biográficas de motociclistas e sua relação com a cultura custom. A pesquisa teve como objetivo verificar a relação entre as narrativas biográficas e a constituição da identidade social e foi realizada através de oito entrevistas biográficas com motociclistas. O material foi analisado seguindo a proposta metodológica de análise de núcleos de significação (Aguiar & Ozella, 2006). Os resultados apontaram que os valores, significados e práticas sociais próprios à cultura custom são ressignificados através da narrativa biográfica buscando evidenciar um estilo que, ao mesmo tempo, implique o sujeito a um grupo social específico e o permita afirmar sua singularidade. Conclui-se que as narrativas são uma mediação fundamental para a formação da identidade social. As narrativas biker custom disponibilizadas pela indústria, pelos meios de comunicação de massa e por grupos sociais específicos formam as referências através das quais a identidade social é constituída. Através de um processo de organização discursiva sobre o contexto cultural, o sujeito estabelece os significados sociais que constituem os grupos dos quais participa e insere-se singularmente nesses grupos.
Explant Surgery: Chronic recoverable Neuropixels in mice v2
Authors: A Aery Jones Emily
Published: February 2023

This protocol collection explains how to build a low-cost, lightweight system to implant 1 Neuropixels 1.0 probe or 2 Neuropixels 2.0 probes into mice, record during freely moving behavior, then recover the probes for future use. This protocol explains how to recover a previously implanted Neuropixel probe and clean for future use. See full collection for more details.
Building a SpikeGLX Rig with camera: Chronic recoverable Neuropixels in mice v2
Authors: A Aery Jones Emily
Published: February 2023

This protocol collection explains how to build a low-cost, lightweight system to implant 1 Neuropixels 1.0 probe or 2 Neuropixels 2.0 probes into mice, record during freely moving behavior, then recover the probes for future use. This protocol first describes how to build a Neuropixels recording system using a National Instruments acquisition system and SpikeGLX software, from parts acquisition through your first recording. It also describes how to integrate a camera, including code and wiring to record and synchronize video frames. See full collection for more details.
Demystifying International Publications: A Structured Training Model to Facilitate UIN SU Lecturers
Authors: Fithriani Rahmah , Salmiah Maryati
Published: February 2023

Writing scholarly papers that meet international standards, such as those indexed by Scopus, has been a source of concern for lecturers at Universitas Islam Negeri Sumatra Utara (UIN SU) Me-dan, thus, became one of the factors that prompted this study. Employing R and D approach through ADDIE model, this research involved 20 lecturers from different educational backgrounds, skills, and units that represented the demographic site of UIN SU Medan as the participants. The results showed that the effective steps of training program for UIN SU Medan lecturers include the followings: 1) Conducting the training program for at least seven meetings; 2) Going through all the six steps of training; 3) Identifying the targeted journals; 4) Going through peer re-viewing process; 5) Improving writing ability: and the last, 6) changing perception. Those findings concluded that an effective training model that is also suitable for the lecturers’ needs is a training model that is like the findings of this study
Intencionalidade e constituição de sentido: a Umwelterlebnis como estrutura intencional de uma filosofia sem sujeito transcendental
Authors: Costa de Matos Fernandes Christiane
Published: February 2023

Argumento que o conceito Umwelterlebnis (vivência do mundo circundante), como Heidegger o apresenta na preleção de 1919 A ideia da filosofia e o problema da concepção de mundo, diz respeito à estrutura intencional de uma filosofia sem sujeito transcendental. Defendo, porém, que o modelo dessa estrutura intencional envolve o autor no problema da constituição de sentido próprio ao projeto da fenomenologia enquanto ciência originária.
Microcalcification of breast cancer: analytic study
Authors: Minh Tanzin
Published: February 2023

Breast cancer is one of the most common cancers worldwide. Breast microcalcifications are deposits of calcium in the breast tissue and appear as small bright spots on mammograms. We searched electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar for information on breast cancer (BC) with microcalcifications through 1990–2022 using keywords such as breast cancer, calcification, microcalcifications. For bibliometric analysis, an online platform for monitoring and analyzing international scientific research using visualization tools and current citation metrics. We analyzed the Scopus database, which included 510 publications. These electronic sources were filtered by the keywords breast cancer, calcification, and microcalcifications. The results of the bibliometric analysis indicate that the number of publications on the specified topic has increased significantly over the past ten years, which shows the relevance of the problem and ways of solving it among scientists. This data supports the idea that the metastatic/invasive breast cancer cells might have more competency for pathological microcalcification as compared to non-metastatic/non-invasive cancer cells.
Importancia de las especies longevas cultivadas y los desafíos para su propagación
Authors: Chura Llanos Luz Satomi , Zirena Vilca Franz
Published: February 2023

En este artículo se realizó una revisión bibliográfica sobre la importancia económica, turística y ambiental de las especies longevas y la problemática relacionada con su propagación vegetativa para su conservación. Muchas de estas especies crecen en los valles interandinos del Perú y se han adaptado a lo largo del tiempo a lugares adversos respecto a los que habitualmente crecen, esto les ha permitido desarrollar fenotipos únicos, que almacenan valiosa información genética, y que deben ser conservados. Sin embargo, estas especies presentan problemas de propagación vegetativa, problemas que se explican a lo largo de este artículo. Concluimos que, a pesar de la gran importancia de estas especies, su factor de edad es el principal problema para su propagación, su conservación y diversidad.
Actividad coagulante del extracto enzimático de tejido abomasal de alpaca sobre leche bovina
Authors: Mujica Lengua Fidel Rodolfo , Hernández Mavila Jack Edson
Published: February 2023

El uso empírico del cuajo de alpaca en la elaboración de quesos artesanales con leche de vaca se encuentra extendido en las comunidades altoandinas del Perú y Bolivia, y no está siendo reportado científicamente. El objetivo del presente estudio fue caracterizar al cuajo de alpaca y evaluar su actividad coagulante. Se colectaron cuajos de alpaca listos para ser usados, directamente de las queserías de cuatro barrios de Viscapalca (Huancavelica-Perú, 4003 msnm); fueron transportados en refrigeración y mantenidos en congelación a -20°C. El Extracto Enzimático Crudo (EEC) se obtuvo por centrifugación a 560 x g por 10 min a 4°C; a partir de él se determinó proteínas por Bradford, perfil electroforético SDS-PAGE, tiempo de coagulación y actividad proteolítica. Se describe también el manejo tradicional del cuajo de alpaca. Se encontró que el EEC contiene 29,80 a 52,91 mg/ml de proteína. El perfil electroforético SDS-PAGE reveló la presencia de por lo menos siete proteínas diferentes, con pesos moleculares entre 91,6 KDa y 15,3 KDa; las más abundantes eran las proteínas de 18,4 KDa y 15,3 KDa, que corresponderían a quimosina y pepsina, respectivamente, ambas de menor peso molecular en comparación con las de origen bovino. El tiempo de coagulación fue 23 min, bajo las condiciones del ensayo; y la mejor actividad proteolítica se registró a pH 5,5. Estos resultados facilitarán más estudios sobre la caracterización molecular del cuajo de alpaca, purificadas previamente las proteínas presentes por cromatografía en columna.
Indicações Clínicas para o Transplante Corneano no Contexto Global: Revisão Integrativa
Authors: Cardoso Mayk Penze , Júnior Marcos Antonio Ferreira , Manvailer Letícia Pinto , Teston Elen Ferraz , Frota Oleci Pereira , Santos Viviane Euzébia Pereira
Published: February 2023

Objetivo: Descrever as principais indicações clínicas para ceratoplastia de acordo com o Índice de Desenvolvimento Humano (IDH) dos países estudados.Materiais e Métodos: Trata-se de uma revisão integrativa de literatura realizada em cinco bases de dados relevantes na área da saúde. A amostra final foi composta por 58 artigos, recuperados das bases: SCOPUS, PubMed Central/MEDLINE, Science Direct, Web of Science e Cumulative Index to Nursing and Allied Health Literature (CINAHL), os quais foram analisados de forma descritiva.Resultados: Das indicações gerais, os estudos apontaram ceratocone (38,7%) como a mais comum, assim como em países com IDH muito alto (22.6%) e países com IDH alto (12,9%) e a ceratite infecciosa em países com IDH médio.Conclusão: As principais indicações para ceratoplastia foram o ceratocone, tanto em países com IDH muito alto quanto alto e a ceratite infecciosa em países com IDH médio. Destacou-se a maior frequência de indicações de causas infecciosas em países com IDH médio devido às fragilidades dos sistemas de saúde para lidar com causa evitáveis, e salienta a necessidade de estratégias para atenção à saúde, diagnóstico precoce e medidas preventivas.
Especificidades no cuidado aos adolescentes no Centro de Atenção Psicossocial infantojuvenil
Authors: Machado Pavani Fabiane Machado , Wetzel Christine , Olschowsky Agnes , Basso da Silva Aline , Kenes Nunes Cristine
Published: February 2023

Objetivo: apresentar as especificidades no cuidado de adolescentes na construção de práticas em saúde mental em um Centro de Atenção Psicossocial infantojuvenil (CAPSi). Métodos: trata-se de uma pesquisa qualitativa, avaliativa e participativa, com base na Avaliação de Quarta Geração. Foi realizada no período de agosto a dezembro de 2018, mediante 300 horas de observação participante e entrevistas com 15 profissionais da equipe de um CAPSi de uma capital. A análise foi realizada concomitante à coleta pelo Método Comparativo Constante. Resultados: foram identificadas como especificidades no cuidado em saúde mental de adolescentes potentes para orientar a construção das práticas no CAPSi: a ambiência, aspectos relacionais e de comunicação entre adolescente e profissional, a plasticidade contínua nas atividades voltadas aos adolescentes no CAPSi. Conclusão: identificou-se a importância do adolescente na construção conjunta com profissionais de estratégias dentro do CAPSi para acolhê-los e vinculá-los ao serviço.
The communicative strategy of sympathy: linguistic means of expression and problems of translation
Authors: Lychuk Mariia , Navalna Maryna , Marchuk Liudmyla , Shchabat-Savka Svitlana , Skliarenko Olesia
Published: February 2023

The article is devoted to the analysis of linguistic means for describing the communicative strategy of sympathy. The study is based on the interpretation of the communicative strategy as a communication model aimed at planning the speech process. The article describes the linguistic means of expressing the communicative strategy of sympathy in English and the activity of using it. In the list of linguistic means, the following ones are marked with certain productivity: certain lexical items, in particular poor; standardized phrases, clichés, etc. The study analyzes the typical means of expressing sympathy, in particular language constructions, in the Ukrainian language. Some language means of expressing sympathy in the Ukrainian language reinforce the dynamic change of speech dynamics. The specificity of the communicative strategy of sympathy in both English and Ukrainian languages is characterized based on fiction. The techniques during the translation of the communicative strategy of sympathy from English to Ukrainian have been determined.
Lexical metaphors in Westlife's selected song lyrics
Authors: Baa Sultan , Wardani Sri Bintang , Iskandar  , Weda Sukardi , Arafah Burhanuddin
Published: February 2023

The study aims to discover lexical metaphors in Westlife's selected song lyrics. Specifically, it was to reveal the types and source domains of the metaphors. Swear It Again, If I Let You Go, Flying Without Wings, I Have a Dream, and Fool Again, which are the legendary boy band's most popular songs according to TraxFM (2017), were selected as the data sources. The study applied the qualitative descriptive method, the study focused on exploring the nature of the study object as proposed by Kothari (2004). Since the phenomena investigated are metaphors in song lyrics, the study adapted Schmitt's (2005) concept of metaphor analysis. The study's data are all metaphors in the five songs of Westlife (Swear it Again, If I Let You Go, Flying Without Wings, I Have a Dream, and Fool Again), which TraxFM (2017) considers as the boy band's best songs ever. The data MIP-Praglejazz was employed to identify the metaphors in those selected song lyrics. The study found: (1) the selected song lyrics contained 15 structural, 24 ontological, and only two orientational metaphors; (2) Most of the metaphors have a concrete thing as their source domain, such as living thing, traveler, place, flame, sunrise, container, bird, and object. It can be inferred that: (1) the song lyrics are dominated by ontological and structural metaphors, and (2) the metaphors are mainly constructed of concrete concepts, which humankind are so familiar with in their daily life. Detailed findings will be presented, and their implications will be discussed.
Features of word formation of new vocabulary in English
Authors: Karlygash Shokhayeva , Auyelbekova Akmarzhan , Shomanova Gulnar , Dutbayeva Saule , Zhapanova Marzhan
Published: February 2023

Word formation is a branch of linguistics in which the ways of forming words of a language are studied. By studying word formation, one can understand the means of enriching the language as a whole. After all, the language we speak is constantly changing, everything that happens in society is reflected in the language through new words and word meanings, and the main source of the appearance of new words in the language is word formation. This article is devoted to the study of word-formation models in the English language. The article contains information about the main word-formation models in the English language, their problems, features and classifications. In addition, this article discusses a new vocabulary, which is constantly replenished by all modern languages due to the intensive development of all spheres of human activity. In this case, English is no exception, and among the many sources that fix neologisms in this language. The focus is on the aspect of word formation of neologisms, namely all the traditional ways: affixation, word composition, reduction and conversion. As a result of the analysis, it was revealed that the word composition occupies the first place in productivity, reduction – in the second, affixation – in the third, conversion – in the last. This means that word composition has not lost its leading positions, and affixation and conversion have become less common. It is interesting to note the continued productivity of the following word composition and conversion models. In affixation, prefixes of Latin origin were the most frequent, as well as such suffixes. Also, this article is an analysis of the main scientific concepts that reveal the essence of the theory of word formation: its place in the language system. The area of controversial issues concerning the morpheme as the main unit of word formation is outlined. The author focuses on a comprehensive approach to the theory of word formation in projection on the practice of word analysis.
EFFECTS OF FACEBOOK ON EXAM PERFORMANCE OF SOCIAL SCIENCES STUDENTS: A CASE STUDY OF THE UNIVERSITY OF MALAKAND
Authors: Khan Asif Nawaz , Ali Sajjad , Amin Salman , Irfan Muhammad
Published: February 2023

Purpose of the Study: As various researchers found, Facebook is one of the most popular social media platforms among students. The purpose of this study was to assess the effect of Facebook on students' exam performance.

Methodology: For this Study, data was collected from the regular students of BS social sciences at the University of Malakand. The researcher used quantitative methodology to obtain fruitful results. A questionnaire was designed to assess the effect of Facebook usage on students, and data was collected from 182 students' by simple random sampling technique. The analysis of the results was carried out through Statistical Package for Social Sciences (SPSS).

Main Findings: The Study found that the Usage of Facebook affects students' exam performance in Malakand. The study's results supported the hypothesis that the more the students used Facebook, their exam performance would be poor.

Application of the Study: This Study is essential to encourage students, parents and teachers to use Facebook for educational and learning purposes because most students use it for leisure time and relaxation. This study will help the students to manage Facebook usage time during exam days and to use it for refreshing and revealing boredom. It will help aware teachers and parents about the adverse effects of Facebook. The study will contribute a little to the existing literature gap on understanding the hurdle and blessing opportunities of Facebook in the exam environment.

The study's novelty: This is an exciting study involving university students and will discover the effects of Facebook on exam performance. The study will be helpful by bringing awareness among university students that Facebook Usage affects their exam performance. The study will also find out the relationship between Facebook usage and achievements in the exam. The students will come to know how spending more time on Facebook during exam days will affect their studies.
BIOCIDAL EFFECTS OF METABOLITES OF STREPTOMYCES GLOBISPORUS 3-1 AND STREPTOMYCES CYANOGENUS S136 STRAINS
Authors: Golembiovska S. L. , Polishchuk L. V. , Bambura O. I.
Published: February 2023

Research of the biocide action of streptomycete-antagonist metabolites on the causative agent of bacterial canker of tomato and on the host-plant fertility is the actual question.
Aim. To determine the action of metabolites of Streptomyces globisporus 3-1 and Streptomyces cyanogenus S136 on the phytopathogen Clavibacter michiganensis 102 in vitro and on seed germination, growth and yield of tomatoes in vivo.
Methods. Microbiological methods in laboratory conditions and descriptive-comparative analysis of growth and development of tomatoes in hothouse conditions were used.
Results. S. globisporus 3-1 and S. cyanogenus S136 metabolites inhibited the growth of the phytopathogen C. michiganensis 102 with the formation of clean zones 45 and 35 mm in vitro, respectively. Pre-sowing treatment with metabolites of S. globisporus 3-1 and S. cyanogenus S136 of tomatoes Lana seeds reduced germination by 27% for both and led to defects in leaf shape and plant sterility, respectively. Treatment by metabolites of both Streptomyces strains of phytopathogen infected seeds did not improve germination, growth, and yield compared to grown plants from infected seeds, though it were visually not defective, sterile and with signs of bacterial canker of tomato.
Conclusion. It was found that metabolites of S. globisporus 3-1 and S. cyanogenus S136 had a biocide action on the phytopathogen C. michiganensis 102 in vitro and on Lana tomatoes in hothouse conditions.
BIOSURFACTANTS OF MARINE MICROORGANISMS: ІІІ. APPLICATIONS IN INDUSTRIAL TECHNOLOGIES
Authors: Galkin B. M. , Finogenova М. О. , Galkin M. B. , Semenets A. S. , Filipova T. О.
Published: February 2023

Summary Surface-active compounds (SAC) and emulsifiers, due to their ability to reduce interfacial tension, are widely used in various industries. Most of the SAC used today are produced from non-renewable petrochemical raw materials and are not safe for living beings and the environment. Biosurfactants (BS) are synthesized by microorganisms from renewable raw materials, in particular, from food industry waste, they are a promising alternative to chemical surfactants due to their biological transformation and environmental friendliness. The advantage of BS produced by marine microbiota is that they exhibit their activity over a wide range of temperatures, pH and salinity. It is shown that these biosurfactants, in addition to surface-active properties, often have other types of activity: antimicrobial, antibiofilm, antioxidant. It has been established that biosurfactants of marine microorganisms can be widely used in industries such as the production of hygiene products, pharmaceuticals, cosmetology, food industry, agriculture, bioremediation, and oil production.
Vitamin C as A Possible Immunity Booster
Authors: Agrawal Anju
Published: February 2023

Deficiency in vitamin C, an essential micronutrient and antioxidant, may result in a compromised immune response because of its central role in immune system regulation. How effective Vitamin C might be in preventing and treating infections is an important question to answer. We reviewed the literature to learn more about vitamin C's role in the health of white blood cells (WBCs) and the expression of genes involved in the immune system and to consider whether or not vitamin C could enhance current therapies.
Etyka brokera ubezpieczeniowego
Authors: Wieteska Stanisław
Published: February 2023

A broker’s activity is one of the elements of insurance mediation. Brokers sell property
and personal as well as life insurance policies. Apart from the range of duties, the quantitative condition
of distribution channels, the paper also discusses problems of a broker’s professional ethics,
which include broadly understood information reliability, activation honesty and assistance in damage
liquidation.
Signed in 1998, the Sobieszew Charter lays out the norms of ethical broker’s activity in three
dimensions: their contacts with clients, mutual contacts and contacts with an insurance company.
As well as that, the Charter created the Commission of Professional Ethics, the role of which is settling
conflicts arising in the above-mentioned dimensions.
The Charter also established seven main principles of professional ethics including the principle
of a fair turnover or that of forming healthy relationships among brokers.
The paper investigates the data concerning ethics in broker organizations, the major elements of
which are a broker’s impartiality, conducting honest negotiations and the duty of submitting identical
requests for proposal to insurance companies. The issue of insurance brokerage is not discussed.
Etyczne problemy sprawowania władzy w zarządzaniu przedsiębiorstwem
Authors: Pawlak Zbigniew , Smoleń Andrzej
Published: February 2023

When power is exercised in the enterprise some ethical issues might occur with business
ownership, personnel policy, working conditions etc.
These issues and ways of addressing them were depicted and interpreted from the perspective of
the Church’s social teachings included in papal encyclicals, viz.: Rerum novarum, Laborem exercens,
Centesimus Annus.
In the Church’s social teachings a number of principles were noticed that are favourable for
the ethical corporate management including the principle of the primacy of work over capital, right to
private ownership, right to establish professional associations, right to fair pay, right to fulfil religious
obligations and having rest during holidays, a duty to support the weak and the needy (solidarity
principle).
The analysis of the social content of papal encyclicals showed two faces of power. On the one
hand it is necessary and has positive effects (introduction of corporate governance, taking right
decisions, prevention of theft and assets devastation etc.); on the other hand improper power exercise
may lead to a number of undesirable effects (corruption, worker discrimination, thriftlessness etc.)
The paper identifies also sources, forms and power exercising planes in the enterprise.
Prawda w mediach
Authors: Zanussi Krzysztof
Published: February 2023

It used to be that if some message came from an oral source, its weight depended on reliability of
the one who had transmitted it and on the one who had heard it. If, on the other hand, something was
printed it intrinsically became credible. Democratization of access to print and similar democratization
of media, apart from its undoubtedly positive side, brings also a negative novum – it encourages
everyone to speak freely.
It is impossible to talk about truth in media, or truth in any other sense, and not relate to
the fashionable nowadays in the humanities the vanquisher of Marxism – called postmodernism.
This very movement in its popular form sows the seeds of fear of all who proclaim the existence of
objective truth or, what is worse, absolute truth. They caution that the supporters of this truth will
introduce it by force, so we are in danger of facing totalitarianism, fundamentalism and dark
dictatorship. It is uncertainty that drives people to violence. Those who have something to hold on to are
more unaffected by despair. The fanatics are often recruited from those who are adrift. Less often from
those with a questing mind. But in order to seek one needs to believe that truth exists. Even if it were
always incomplete and imperfect in the form in which we are able to assimilate it.
To the charges that every certainty leads to violence, I reply that most frequently it is
the opposite. It is fear and feeling adrift that drive people to the false certainty. Whoever believes that
truth exists will easier accept that he will never grasp it.
In the very important debate that was conducted some years ago, the fear of fundamentalism was
juxtaposed with the fear of nihilism. I see the latter as a greater threat.
Uczestnictwo w polityce jako moralna powinność obywatela
Authors: Sobuś Ks. Paweł Bogumił
Published: February 2023

According to the Aristotelian definition, politics is a co-formation of social life within human
capacity in the conditions of freedom and equality, while under specific authority. In a more narrow
sense, it is understood as the art of administration. In a broader sense, it denotes any care for public life.
Every citizen, as a member of a community, takes advantage of goods it has produced.
Their participation cannot resemble the situation of a person subjected to a transfusion; instead, it must
manifest itself in their contribution to the development of society.
One of the aspects of the commitment to social life is political activity. It should not limit itself to
the activity of politicians themselves, but, to a greater or lesser extent, it should engage all citizens.
It is by their participation in political elections that citizens undertake an effort of shaping reality.
The formation of the young generation’s attitudes is another manner in which parents and teachers
manifest their care for social life.
Oxidative Stress in Goats with Peste des Petits Ruminants (PPR)
Authors: Bharti Archana , Verma Yamini , Dubey Amita , Swamy Madhu , Sahoo Kamlesh Kumar , Gupta Devendra Kumar
Published: February 2023

Background: Goats in India are endangered by various disease outbreaks. A limited number of disease conditions in goats have been investigated with regard to the effect of oxidative stress. Oxidative stress is an active field of research implicated in numerous disease processes including sepsis, enteritis, pneumonia, mastitis, joint diseases etc. The present work was undertaken to study the oxidative stress contributing pathological changes in naturally occurring Peste des petits ruminant virus (PPRV) in goats of Jabalpur region. Methods: A total of 30 positive PPR samples (19 plasma and 11 lung tissues) were processed for oxidative stress assessment by oxidative stress markers malondialdehyde (MDA) and glutathione (GSH). The oxidative stress was revealed among 30 PPR positive goats when compared with 10 healthy animals. Necropsy examination was conducted to observed gross pathology and lung tissues were collected for histopathological examination. Result: Oxidative stress was observed with decreased GSH and increased MDA concentration among PPRV positive goats in plasma and in lung tissues respectively. Nineteen PPR positive goats revealed different degree of clinical signs and were devided into three groups viz group I mild, group II moderate and group III severe. Grossly, eleven positive goat carcasses revealed pneumonic lesions. Microscopically, lung sections revealed broncho-interstitial pneumonia. These findings are suggestive of oxidative stress induces pathological changes and lead to dehydration and death of goats.
Appraisal of E-Learning and students’ academic performance: A perspective from secondary schools
Authors: Olusegun Adebayo Adeokun , Uranta Elnathan , Ukhurebor Kingsley Eghonghon , Jokthan Grace , Nalwadda Dorothy
Published: February 2023

This study investigated the effects of electronic learning (e-learning) on the academic performance (AP) of students in selected secondary (high) schools. A cross-sectional survey was used in this study to get data regarding students’ AP. The study was limited to three e-learning platforms (Zoom, WhatsApp, and Google Classroom) which were used by the participants in the survey during the COVID-19 pandemic-induced lockdown. A quantitative statistical analysis was carried out on the gathered data using SPSS. Analyses showed that e-learning had a negative effect on the attitudes of students. Furthermore, the analysis revealed that the e-learning systems were not as effective as traditional face-to-face teaching due to factors such as poor network connectivity and lack of collaborative activities. Furthermore, it was discovered that the e-learning materials were not widely available and accessible to the participants. Finally, suggestions that would guide further studies and improve student AP were also recommended.       
Keywords: Academic performance, E-learning, Learning, Student, School
Study of opportunities and professional needs of university teachers of Kazakhstan in professional development
Authors: Sapieva Maira , Bulatbayeva Kulzhanat , Mazbayev Ordenbek , Pussyrmanov Nurbek
Published: February 2023

The purpose of the research is to study the current opportunities for professional development of teachers of pedagogical educational institutions of Kazakhstan and their needs for professional growth, as well as to develop recommendations for improving their professional level. The described results are based on the normative documents regulating the professional development of university professors. The non-progressiveness of the professional standard of the teacher of Kazakhstan has been substantiated. Besides, there was a survey of 614 lecturers of pedagogical training facilities to determine their need for professional development. The sample was random and the data collection was carried out using a questionnaire. In the end of the study, the current state of the problem has been described, the data obtained from the results of the survey have been summarized, problematic aspects of professional growth have been identified and some recommendations have been developed for improving the professional development of pedagogical facilities lecturers in Kazakhstan.
Keywords: continuing professional development, professional needs of teachers, Professional standard of a teacher, teacher professional development, University teachers.
The impact of internet use on tertiary institution students’ academic performance: An exploratory study
Authors: Emeka Egbo Philip , Okoza Jolly , Ukhurebor Kingsley , Onwodi Gregory , Bayonle Fadayomi , Nyagblordjro Joshua
Published: February 2023

This study investigates the impact of internet use on tertiary institution students’ academic performance (AP). The objectives of the study are to ascertain the impact of internet usage on the AP of students in tertiary institutions, find out some of the difficulties encountered in the utilization of the internet by students in tertiary institutions, and determine some of the benefits of internet usage to students in tertiary institutions.  The sample size for this research consists of 300 students whose data were collected through the administration of questionnaires. The study employed the survey research method and the Chi-square (X2) method to analyse and test the various hypotheses formulated. Findings from the study show that there is a significant relationship between internet usage and the AP of students in tertiary institutions. Even though internet usage makes work faster and easier, there are various difficulties encountered in the utilization of the internet by students in tertiary institutions, and the study recommends some ways that will assist to mitigating these difficulties, as well as ways to improving internet use by tertiary institution students.
Keywords: Academic performance, Institution, Learning, Student, Teaching
Systems Thinking and Practice: A guide to concepts, principles and tools for FCDO and partners
Authors: Woodhill Jim , Millican Juliet
Published: February 2023

This guide is a basic reference on systems thinking and practice tailored to the context and needs of the UK Government’s Foreign, Commonwealth & Development Office (FCDO). It is an output of the FCDO Knowledge for Development Programme (K4D), which facilitated a Learning Journey on Systems Thinking and Practice with FCDO staff during 2021 and 2022. The guide offers a common language and shared framing of systems thinking for FCDO and its partners. It explores what this implies for working practices, business processes and leadership. It also offers links to additional resources and tools on systems thinking. We hope it can support systems thinking to become more commonplace within the culture and practices of FCDO and working relations with partner organisations.
Consensus for the Early Identification of Secondary Progressive Multiple Sclerosis in Portugal: a Delphi Panel
Authors: Sá Maria José , Basílio Carlos , Capela Carlos , Cerqueira José João , Mendes Irene , Morganho Armando , Correia de Sá João , Salgado Vasco , Martins Silva Ana , Vale José , Sousa Lívia
Published: February 2023

Introduction: Multiple sclerosis is a disease with a heterogeneous evolution. The early identification of secondary progressive multiple sclerosis is a clinical challenge, which would benefit from the definition of biomarkers and diagnostic tools applicable in the transition phase from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis. We aimed to reach a Portuguese national consensus on the monitoring of patients with multiple sclerosis and on the more relevant clinical variables for the early identification of its progression.Material and Methods: A Delphi panel which included eleven Portuguese Neurologists participated in two rounds of questions between July and August of 2021. In the first round, 39 questions which belonged to the functional, cognitive, imaging, biomarkers and additional evaluations were included. Questions for which no consensus was obtained in the first round (less than 80% of agreement), were appraised by the panel during the second round. Results: The response rate was 100% in both rounds and consensus was reached for a total of 33 questions (84.6%). Consensus was reached for monitoring time, evaluation scales and clinical variables such as the degree of brain atrophy and mobility reduction, changes suggestive of secondary progressive multiple sclerosis. Additionally, digital devices were considered tools with potential to identify disease progression. Most questions for which no consensus was obtained referred to the cognitive assessment and the remaining referred to both functional and imaging domains.Conclusion: Consensus was obtained for the determination of the monitorization interval and for most of the clinical variables. Most questions that did not reach consensus were related with the confirmation of progression taking into account only one test/domain, reinforcing the multifactorial nature of multiple sclerosis.
Creeping attachment post-gingival recession treatment using a vestibular incision subperiosteal tunneling access technique combined with a connective tissue graft
Authors: Prathivi Hapsari Kartika , Sari Rezmelia
Published: February 2023

Background: The exposed roots of teeth due to gingival recession can generate dentin hypersensitivity and esthetic problems because a patient feels that the teeth, especially the anterior teeth, look long. Recession in thin anterior gingiva often brings unsatisfactory treatment results, so mucogingival surgery, such as vestibular incision subperiosteal tunneling access (VISTA) with the addition of a connective tissue graft (CTG), can be chosen as an appropriate treatment technique. Purpose: This case report describes the creeping attachment phenomenon after treatment of anterior gingival recession with VISTA and CTG techniques. Case: A 28-year-old female patient came with Miller Class I gingival recession in thin anterior gingiva and malposition teeth, complaining about pain and esthetic problems. Case management: The patient was treated with a VISTA technique combined with CTG. The creeping attachment phenomenon seen at three months postoperatively obtained good root coverage so that the patient’s complaints were resolved even though periodic control was needed to evaluate oral hygiene. Conclusion: VISTA and CTG techniques are appropriate for treating anterior mandibular gingival recession with minimal trauma and provide significant results.
Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor
Authors: Kharisma Viol Dhea , Utami Santika Lusia , Rizky Wahyu Choirur , Dings Tim Godefridus Antonius , Ullah Md Emdad , Jakhmola Vikash , Nugraha Alexander Patera
Published: February 2023

Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV. Zingiber officinale var. Roscoe or ginger is often used as an alternative remedy. Currently, there are no known in vitro or in vivo studies that investigate ginger as an MuV antiviral. Purpose: This study aims to evaluate the antiviral potency of the bioactive compounds in Zingiber officinale var. Roscoe against MuV. Methods: Antiviral activity screening was conducted by druglikeness analysis, antiviral probability, molecular docking, and molecular dynamic simulation. Results: As an antiviral, 6-shogaol from Zingiber officinale var. Roscoe has potency against MuV. It has a good binding affinity and can establish interactions with the binding domain of the target protein by forming hydrogen, Van der Waals, and alkyl bonds. Conclusion: The complex of 6-shogaol_NP was predicted to be volatile but stable for triggering inhibitory activity. However, these results must be proved by in vivo and in vitro approaches to strengthen the scientific evidence.