bluuebunny/crossref_metadata_2025 huggingface dataset:
Pancreatite aguda induzida por vincristina em cão com linfoma multicêntrico
Authors: Kalil Rebeka Ferro Tosta
Published: February 2025

Chemotherapy treatment in dogs requires great care and attention to the patient, since the medications utilized have side effects. The most common side effects are vomiting, nausea, diarrhea, loss of appetite and weight loss, which can be clinical signs of some pathologies such as pancreatitis. The objective of this report is to alert veterinary oncologists about the reactions that chemotherapy drugs can cause in patients, correctly guiding guardians about possible complications.
Epilepsia em cão
Authors: França Pedro Henrique Maglio , Barros Michele Andrade de , Almeida Gabriela Barbosa de , Miranda Mariana Santos de
Published: February 2025

This work aimed to report the case of a patient who was presented at the Veterinary Clinic of the Pontifical Catholic University of Campinas (São Paulo, Brazil), in November 2023, with a history of epilepsy. Epilepsy is a disease characterized by the occurrence of convulsive crises, and which has been frequently found in the veterinary routine. Neurological disorders are complex to identify and treat, and epilepsy is an example of this. The difficulty begins with the diagnosis, where the identification, or lack thereof, of convulsive crises can depend greatly on the guardian's perception and report.  Furthermore, the list of differential diagnoses is extensive and the elimination process and search for a cause can take time. Regarding treatment, there are few drugs with proven efficacy nowadays, with phenobarbital and potassium bromide being most relevant in the treatment of epilepsy. Even with the institution of drug therapy, there are several factors that interfere with the assertiveness of the treatment, from the guardian's compliance in the administration or carrying out of monitoring exams, to the receptivity and response of each organism to medications and dosage. Success in therapy can be achieved when the patient presents a decrease in the frequency, duration and intensity of episodes, as complete interruption is not commonly seen.
Zeitenwende Meets Energiewende
Authors: Wolf Holger
Published: February 2025

Energy policy involves complex goal trade-offs between sustainability, affordability, and security. Germany's Energiewende long favored the first. The Zeitenwende prompted by Russia's invasion of Ukraine forced a rethinking of the long-held belief in reliable cheap gas imports, and thus the weight given to affordability and security. This article explores both the immediate crisis response and the lasting impact on broader energy policies. Contrary to widely held perceptions of deliberative decision-making, the crisis response was decisive, flexible, and (if at a high cost) largely successful. This decisiveness, however, did not feed through to tackling the structural challenges already plaguing the Energiewende before the war. 2030 policy targets increasingly appear aspirational while energy costs loom large for both households and firms.
The Formation and Consolidation of a Motley Crew
Authors: Truffer Johannes , Frei Nadine , Schubert Iljana , Sohre Annika , Nachtwey Oliver
Published: February 2025

The state response to the covid-19 crisis triggered fierce protests in German-speaking countries. Our study aims to provide an overview of the German and Swiss protest movement by examining the socio-structural make-up and worldviews of members of Corona-skeptical Telegram chats, the public appearance of protests, and the movement's collective identities. Using a mixed-methods approach, we analyzed survey (n = 1089), interview (n = 45), and ethnographic data, all collected between 2020 and 2022. Our findings suggest a heterogeneity of Corona-skeptics, revealing three distinct worldviews that focus on esoteric, conspiracy, and right-wing topoi. We paralleled these patterns with qualitative data and linked them to three groups present at Corona protests. Additionally, we found that collective identities—specifically, the “critical expert” and the “heroic resistance fighter”—played a crucial role in unifying the movement.
Nanocarrier-Based Therapeutics and Theranostics Drug Delivery Systems for Next Generation of Liver Cancer Nanodrug Modalities
Authors: Zahid Dua , Tahir Rabia , Ashfaq Wajiha , Wasay Abdul , Iqbal Qamer
Published: February 2025

This review focuses on the physicochemical properties of nanocarriers (NCs) and the physical properties of the tumor microenvironment (TME), highlighting strategies used to specifically deliver molecules of interest to specific lesions. This review discusses these products, explains the simple selection of high-performance and active methods, and illustrates this with examples of drugs that are focused on clinical research or treatment. The last few years have seen an increase in targeted delivery of anticancer drugs. Although many trials have been completed, only a few targets of nanocarriers have been approved for clinical use, and no interaction with nanoparticles has been confirmed. Here we review the details of these two processes and their effects on the tumor microenvironment. We also focus on the limitations and advantages of each system at both laboratory and commercial scales. The current article discusses how NC and enhanced access and retention affect passive targeting.
Increasing Financial Literacy of West Jakarta City MSMEs Through SIAPIK Application Training
Authors: Rahayu Puji , Meiyanti Ruci , Tarmidi Deden , Putra Yananto Mihadi , Maulana Goffari
Published: February 2025

UMKM di Indonesia terus meningkat secara kuantitas meski tidak selalu dalam kualitas, padahal Pemerintah mengharapkan UMKM naik kelas. Salah satu yang merupakan kendala stagnannya UMKM dan terkadang gulung tikar adalah ketidakmampuan UMKM dalam menganalisis kinerja usahanya dan tidak memiliki target di masa mendatang. Laporan keuangan dapat membantu UMKM dalam menganalisis kinerja masa lalu dan target masa mendatang, namun banyak kendala dihadapi UMKM dalam penyusunan laporan keuangan. Kegiatan Kemandirian Masyarakat ini dilakukan dengan metode sosialisasi penyusunan Laporan Keuangan menggunakan SIAPIK yang dicetuskan Bank Indonesia, serta praktik dan studi kasus penyusunan laporan keuangan sederhana berdasarkan SAK EMKM. Berdasarkan Pretest dan Posttest yang dilakukan, terjadi peningkatan pemahaman dan kemampuan peserta yaitu pelaku UMKM di Kota Jakarta Barat dengan 100%  menyatakan kebermanfaatan pelatihan SIAPIK serta bersedia untuk menggunakan aplikasi SIAPIK pada penyusunan laporan keuangan usaha. Dengan kegiatan ini diharapkan UMKM bertambah sadar akan manfaat laporan keuangan bagi keberlangsungan bisnis.
E-Catalogue Utilization Counseling for Small and Medium Enterprises Association in Surakarta City
Authors: Kristina Setyowati  , Septyanto G. Prakoso  , Is Hadri Utomo  , Herwan Parwiyanto  , Retno Suryawati  , Rino A. Nugroho  , Priyanto Susiloadi  , SA Santoso
Published: February 2025

The existence of the e-catalog program began to grow rapidly in Indonesia. However, currently, the understanding of SMEs related to the use of e-catalogs is still low. Moreover, currently, most of the consumers and public facilities built have started to use digital technology, so SMEs must be able to integrate their business with technological developments, especially through e-catalogs to make it easier to market their goods and services. The e-catalog is currently aimed at encouraging revenue growth in the SME sector and the government sector to reduce corruption rates related to the procurement of government goods and services. This community service is carried out by providing counseling related to e-catalogs to the Solo UMKM Association (PUS). The results of this counseling show that counseling related to the e-catalog is in accordance with the needs of UMKM players in Surakarta City and answers the concerns of UKM players in Surakarta City regarding how to access and use the e-catalog itself so that it can support the achievement of the government's target of using e-catalogs.
Economic Empowerment of Tourism Conscious Housewives Through Social Media Marketing and Product Packaging Design
Authors: Khatimah Husnil , Abel Tasman  , Wiwik Indrayeni
Published: February 2025

The Community Partnership Program aims to provide education and assist partners in solving priority problems by using strategic aspects of marketing, finance and product design in the form of a simple and easy to run business model that includes aspects of main partners, main activities and value propositions. The partner for this PKM activity is the Tourism Awareness Women's Group in the East Timbulan Painan tourist area in IV Jurai District, South Coast. In PKM activities, partners will collaborate and be involved in the training provided in the form of creating a business website, assisting in creating promotional content on social media, discussing variations and packaging of business products, as well as how to collaborate with outside parties, managing business finances so that partners are able to increase income. in terms of production and marketing. This PKM is expected to be able to contribute to the community, especially to POKDARWIS women independently and sustainably in accordance with government programs to improve the community's economy in local tourist destinations. The specific targets for this activity are: 1) Increase in partner turnover; 2) Increasing competitiveness (HR, raw materials, production processes, products, marketing; 3) Increasing the quality of partner/SME management (level of IT use, completeness of standard management procedures; 4) Product packaging design, social media content; 5) Increased understanding and skills of partners. The approach methods offered to solve partner problems are 1) Providing training on creating business websites that are used to market pastries and traditional food business products; 2) Increasing knowledge insight through assistance in creating product content that will be promoted through social media; 3) Provide packaging design training for pastries and traditional food businesses with certain characteristics; 4) increase the broadest knowledge of partners regarding business cooperation so that business capital does not rely on personal sources.
Hydroponic Assembly Training for Teachers and Senior High School Students in Kuantan Singingi
Authors: Seprido Seprido , Desta Andriani  , A. Haitami  , Elfi Indrawanis  , Chairil Ezward  , Gusti Marlina  , Wahyudi  , Tri Nopsagiarti
Published: February 2025

Education is a very important need in society’s life. High school students and equivalent teachers are educational people who continuously learn. Hydroponics is a technology in the agricultural sector that can be adopted in the education sector. A total of 68 participants attended this hydroponics training activity, 22 were teachers and 46 were senior high schools student. All participants showed quite high enthusiasm in this training activity as shown by the high frequency of questions from all participants.
Differentiated Learning: A Solution to Increase Students’ Potential Seen from Students’ Readiness to Learn, Interests and Learning Profiles
Authors: Kristiawan Muhamad , Connie Connie , Asvio Nova , Risanto Wisdi
Published: February 2025

Differentiated learning is important to be mastered by future teachers, along with the development of education policies in Indonesia that provide equal opportunities for all Indonesian children to learn. This service is in the form of training for prospective teachers which aims to provide them with provisions to be able to teach in classes that have different learning styles, interests, and needs, so that they require different approaches to achieve optimal levels of understanding and achievement. The service method used is a tutorial, where participants are able to use various strategies, such as providing diverse materials, grouping students based on ability or interest, giving different assignments, and providing additional support or challengers according to individual needs. Participants who took part in this service were students of PGMI UIN Fatmawati Sukarno. As a result of the service, the participants have an approach to teaching that allows them to adjust teaching methods, materials, and assessments according to the needs and skill levels of individual students.
Perspectives on Academic Freedom in the Context of Transformation (insights Ukraine and Germany)
Authors: Auhunas Sabina
Published: February 2025

The article examines the current state of academic freedom in Ukraine and Germany in the context of their historical, social, and political challenges. Particular attention is paid to the impact of the Soviet legacy, bureaucracy, financial constraints, and the full-scale war in Ukraine on the functioning of educational and scientific institutions. The key aspects that define academic freedom are analyzed, including institutional autonomy, freedom of teaching, research, democratization of university culture, and international cooperation. The scientific novelty of the paper lies in identifying the interrelationships between the challenges of the post-Soviet legacy, structural barriers, the impact of war, and the prospects for international integration to strengthen academic freedom. The authors rely on the results of a thematic analysis of the discussion panel “Perspectives on Academic Freedom” held within the framework of the international conference “Open Science and Innovation in Ukraine 2024” (OSICU2024) and the German Year of Science 2024 - Academic Freedom initiative. The article identifies eight key thematic categories: academic freedom and autonomy, post-Soviet challenges, freedom of speech and censorship, funding and resource allocation, structural barriers, the impact of war on the academic environment, cultural and democratic development, and international cooperation. In each of these areas, the main challenges faced by Ukrainian and German universities are revealed and ways to address them are suggested. Considerable attention is paid to the issues of financial autonomy, which is the basis for the realization of academic freedom. The article discusses the need to increase basic state funding in Ukraine and to reform grant mechanisms in Germany. It is pointed out that international cooperation can play a crucial role in overcoming the challenges of war, involving Ukrainian scientists in the global academic community, and implementing best practices in university management. In addition, the study emphasizes the importance of developing democratic approaches to university governance and fostering a culture of openness and critical thinking. The results of the study offer recommendations for strengthening institutional autonomy, reducing bureaucracy, increasing the financial sustainability of universities, and ensuring academic freedom in the face of global and local challenges. The article contributes to the theoretical and practical understanding of the ways of transformation of the Ukrainian higher education system and its integration into the European educational space..
Application of The “Smart Manufacturing” System to Detect a Fire in an Industrial Premises
Authors: Grigoreva Elizaveta , Ushakov Vitaly
Published: February 2025

The article considers the issue of identifying patterns between the readings of various sensors to reduce the number of false alarms of the fire safety system in an industrial premises. The identified rules will be used in the “Smart Manufacturing” system being developed.
Możliwość „zasądzenia dotacji oświatowej” bezpośrednio na podstawie ustawy – analiza problemu
Authors: Wolszczak Paulina
Published: February 2025

Significant doubts have been raised in the case law as to the proper legal basis of the beneficiary’s claim against the subsidising entity for compensation of the underpaid educational subsidy. For many years, the prevailing view was that this claim had arisen directly from a provision of the statute as a demand for performance of an obligation in kind. The starting point was the assumption of the civil law nature of this relationship. Even if this assumption is considered correct, due to the special regime of public finance, a claim for the performance of the obligation in kind could only appertain to the subsidised entity during the financial year for which the educational subsidy in question was or should have been granted. After that date, payment or supplementation of the subsidy would become impossible to fulfil for legal reasons beyond the control of the subsidising entity. Thus, the obligation would expire by law without any obligation for compensation.
Analisis SWOT Standar Operasional Pelayanan Pendaftaran Haji kepada Calon Jamaah
Authors: Anggara Budi , Chan Sukmasari Dewi
Published: February 2025

Penelitian ini mengungkapkan analisis SWOT dalam pelayanan pendaftaran Haji di Kementerian Agama Kota Metro dari kekuatan, kelemahan, pelung dan ancaman merupakan suatu analisis yang telah banyak digunakan oleh lembaga/organisasi. Rumusan masalah yang ada adalah bagaimana pelayanan pendaftaran Haji di Kementerian Agama Kota Metro.
            Penelitian ini bertujuan untuk mengetahui pelayanan pendaftaran Haji di Kementerian Agama Kota Metro yang meliputi kekuatan, kelemahan, peluang, hambatan.
Dalam penelitian ini, jenis penelitian ini menggunakan penelitian field research. Sifat penelitian ini adalah deskriptif kualitatif. Teknik analisis data menggunakan teknik data kualitatif dengan berpikir induktif. Sumber data yang diperoleh dari melalui sumber data primer dan sumber data sekunder, dengan menggunakan metode mengumpulan data melalui wawancara, observasi dan dokumentasi.
Berdasakan penelitian yang telah dilakukan di peroleh hasil dan kesimpulan sebagai berikut: pelayanan Pendaftaran Haji di Kementerian Agama Kota Metro sudah cukup baik dalam sebuah pelayanan bagi calon jamaah yang akan melakukan pendaftaran seperti kemudahan dalam pengurusan pelayanan, mendapatkan pelayanan yang baik, mendapatkan perlakuan yang sama tanpa pilih kasih namun dalam kenyataanya belom semuanya maksimal dalam penerapanya hal tersebut terlihat adanya kendala dalam akses internet yang menghambat dalam kelancaran pelayanan pendaftaran haji serta pemahaman calon jamaah haji berbeda-beda saat proses pemberian pelayanan di Kementerian Agama Kota Metro.
Analysis of the status of the establishment of Ukrainian national identity: preprint
Authors:   Institute of Problems on Education of the NAES of Ukraine, Zhurba Kateryna , Bekh Ivan ,   Institute of Problems on Education of the NAES of Ukraine, Kanishevska Liubov ,   Institute of Problems on Education of the NAES of Ukraine, Kornienko Anna ,   Institute of Problems on Education of the NAES of Ukraine, Malynoshevskyi Ruslan ,   Institute of Problems on Education of the NAES of Ukraine, Reipolska Olha ,   Institute of Problems on Education of the NAES of Ukraine
Published: February 2025

The preprint examines and analyzes the current state of fostering Ukrainian national identity among children and school-aged students. Based on the results of a survey conducted with children of various age groups and teachers, it highlights trends and challenges that need to be understood and addressed in the organization of educational activities across different types of educational institutions. Special attention is given to the work of educators in the context of martial law.
This preprint is intended for scientists, teachers, educators, and all professionals in the fields of education and culture.
Islamic Inheritance Law Reform in Indonesia from the Perspective of Islamic Legal Politics: Strategies and Implications
Authors: Firmansyah Heri , Nas Zulkifli
Published: February 2025

This research aims to analyze the reform of Islamic inheritance law in Indonesia, with a particular focus on government policies supporting this reform. The study examines legal doctrines in the Compilation of Islamic Law, jurisprudence, Supreme Court guidance letters for religious courts, and fatwas from the Indonesian Ulema Council. Employing a historical and Islamic legal political (fiqh siyasah) approach, it explores the background and dynamics of these reforms. The reform process involves updating legal concepts, norms, and techniques, driven primarily by the executive and judiciary, while legislative bodies are constrained by their inability to pass laws. Non-governmental institutions, particularly the Indonesian Ulema Council, also play a pivotal role. Scientifically grounded methods, such as ijtihad intiqa'i tarjihi and ibda'i insha'i, serve as the foundation for these reforms. The government’s strategies within the Islamic legal-political framework (fiqh siyasah) are (1) developing Islamic inheritance law in line with societal practices, (2) codifying it into legislative products, (3) compiling it into unified legal texts, (4) enacting legal products such as presidential instructions, fatwas, and jurisprudence, (5) involving scholars, officials, and judges in shaping reforms, (6) creating regulations for non-litigious inheritance distribution based on Islamic law, and (7) engaging the community in inheritance practices. This research’s novelty lies in its comprehensive analysis of both governmental and non-governmental roles in reforming Islamic inheritance law through integrative legal-political strategies. Additionally, it highlights the innovative application of ijtihad intiqa'i tarjihi and ibda'i insha'i, contributing to the modernization and contextualization of Islamic inheritance law in Indonesia. The contribution of this research is its exploration of the interplay between legal reform and societal practices, providing a new understanding of the mechanisms that shape Islamic law in contemporary Indonesia. Furthermore, it offers valuable insights into the role of both religious scholars and government authorities in the legal reform process, offering a model for integrating Islamic law with modern legal systems.
The Influence of E-Recruitment and Job Characteristics on Pursuit Job Intention with Company Reputation as Moderator
Authors:   Faculty of Economy and Business, UPN “Veteran” Yogyakarta, Gina Nabila , Siswanti Yuni ,   Faculty of Economy and Business, UPN “Veteran” Yogyakarta, Sudaryati Sudaryati ,   Faculty of Economy and Business, UPN “Veteran” Yogyakarta
Published: February 2025

This study aims to determine the influence of e-recruitment and job characteristics on the pursuit of job intention of graduated student University in Yogyakarta city and company reputation as moderating variable. The study uses multiple linear regression analysis and moderated regression analysis with SPSS (Statistical Package for the Social Sciences) as a test tool. Sampling was carried out using purposive sampling, and the number of samples was 87 graduated students from 2017 & 2018 at ABC University, especially in the Management Study Program. The result of this research indicates that e recruitment and job characteristics have a positive effect and significance on job pursuit intention. Company reputation as a moderate variable can strengthen the relationship between e-recruitment and interest in applying for work and job characteristics with interest in applying for work. The novelty of this research is that the company's reputation is one of the important variables that can strengthen the influence of recruitment and job characteristics on the interest of job seekers, where the results of previous research are still minimal. This research has theoretical and practical implications that are important to discuss further.
Analysis of Green Marketing Mix and the Purchase Intention of Environmentally Friendly Products
Authors:   UPN “Veteran” Yogyakarta, Dewi Alivia Zahra Kirana , Liestyana Yuli ,   UPN “Veteran” Yogyakarta, Wahyuningsih Tri ,   UPN “Veteran” Yogyakarta, Utami Yekti ,   UPN “Veteran” Yogyakarta, Oetomo Hadi ,   UPN “Veteran” Yogyakarta, Tugiyo Tugiyo ,   UPN “Veteran” Yogyakarta, Sudaryatie Sudaryatie ,   UPN “Veteran” Yogyakarta
Published: February 2025

The study aims to analyze the effect of green marketing on the purchase intention of environmentally friendly products. The variables used are green product, green price, green place, green promotion, and purchase intention. This research uses quantitative methods. The data collection method was a questionnaire distributed to 132 respondents who knew about environmentally friendly products. The analytical method used is multiple regression analysis. The results of this research show that green products, green prices, and green promotions have a positive effect on purchase intention. Meanwhile, green places do not positively influence purchase intention. Green places do not affect purchase intention because the location or distribution of environmentally friendly products is not a consideration for potential buyers. Several factors may have caused the green place not positively to affect purchase intention. However, researchers have not examined this; it is hoped that future researchers can examine the phenomenon of green places not positively affecting purchase intention.
Quantum Computing: Revolutionizing Advanced Risk Management Systems
Authors: Pradeep Kumar Chilukury
Published: February 2025

This article examines how quantum computing revolutionizes sophisticated risk management systems in several industries, focusing on cybersecurity and financial services. It looks at how quantum computing technology transforms conventional risk assessment methods, fraud prevention, and security architecture by utilizing quantum bits and the concepts of superposition and entanglement. The creation of quantum-resistant cryptographic algorithms, the application of quantum-enhanced probabilistic analysis for financial risk management, and the obstacles to the broad adoption of quantum computing are all examined in this article. The article illustrates the substantial potential of quantum computing in enhancing risk management frameworks while stressing the factors that must be considered for successful adoption by examining current market trends, technological advancements, and industry applications. The convergence of quantum computing with other cutting-edge technologies like blockchain and artificial intelligence for improved risk management capabilities is also examined, as are the broader ramifications for industries other than finance, such as healthcare, manufacturing, and telecommunications.
Event-Driven Serverless Architectures for High-Scale Customer Support: An Empirical Analysis
Authors: Bharath Kumar Reddy Janumpally
Published: February 2025

Serverless computing has emerged as a transformative paradigm for building scalable cloud applications, yet its application in customer support systems remains largely unexplored. This article presents a comprehensive analysis of a cloud-native serverless architecture designed to address the scalability challenges inherent in modern customer support operations. The article proposes an event-driven framework that leverages Function-as-a-Service (FaaS) platforms across major cloud providers, demonstrating significant improvements in resource utilization and cost efficiency compared to traditional microservices architectures. Through empirical evaluation and real-world case studies, the article analyzes the performance characteristics of our proposed architecture under varying workload conditions, with particular attention to cold start latencies and event processing throughput. The findings reveal that serverless architectures, when properly implemented with event orchestration systems like Apache Kafka or AWS EventBridge, can provide superior scalability and cost benefits while maintaining system reliability. The article also identifies key architectural patterns and implementation strategies that organizations can adopt to optimize their customer support infrastructure, particularly during peak load periods.
Glyco-engineering Using Pneumococcal Exoglycosidases: A Pilot Study on Deglycosylation of Human Alpha-1-Acid Glycoprotein
Authors: Praveen Gautam  , Neeraj Verma
Published: February 2025

Glyco-engineering is an emerging field that focuses on modifying glycan structures to enhance or alter biological functions. Enzymatic glycan remodeling has numerous applications in biopharmaceuticals, vaccine development, and glycan-based diagnostics. Pneumococcal exoglycosidases, such as neuraminidase NanA and β-galactosidase BgaA, selectively hydrolyze terminal sugars from glycoconjugates, making them potential tools for glyco-engineering. However, their ability to modify human glycoproteins in vitro remains largely unexplored. In this study, we assessed the glyco-engineering potential of pneumococcal exoglycosidases by examining their role in deglycosylating human alpha-1-acid glycoprotein (AGP), a plasma glycoprotein involved in inflammation. Our results demonstrate that NanA removes terminal sialic acid residues from AGP, enabling subsequent galactose removal by BgaA, as confirmed by SDS-PAGE and lectin blot analysis. These findings provide experimental evidence supporting the utility of pneumococcal glycosidases for enzymatic glyco-engineering.
Exame Citopatológico em Minas Gerais: Análise do Indicador do Previne Brasil dos Anos 2022-2023
Authors: Silva Paulo Roberto Mendonça , Santos Lorrainy de Sousa , Souza Giovanna Vieira de , Bezerra Ana Paula de Lima , Almeida Vanessa de , Campos Kátia Ferreira Costa
Published: February 2025

Introdução: No Brasil, excluindo o câncer de pele não melanoma, o câncer do colo do útero é o terceiro mais incidente entre as mulheres e a realização do exame citopatológico continua sendo a estratégia mais adotada para o rastreamento. Entre as estratégias, encontra-se o Previne Brasil, o qual objetiva ampliar os atendimentos da porta de entrada e prevê a integralidade do cuidado à saúde da mulher. Objetivo: Analisar a evolução do indicador de cobertura do exame citopatológico do Previne Brasil dos anos de 2022 e 2023 em Minas Gerais. Método: Estudo quantitativo e descritivo, com dados do Departamento de Informática do Sistema Único de Saúde e do Sistema de Informação em Saúde para a Atenção Básica, transferidos para o software Excel, de forma que cada município foi alocado na sua Macrorregião para identificação dos desempenhos. Resultados: Avaliando o alcance da meta do indicador, nota-se uma progressão na cobertura do exame, que elevou o número de municípios que alcançaram a meta do indicador (>40%). Paralelamente, ocorreu diminuição do número de neoplasias malignas e aumento no número de diagnósticos na fase inicial da doença. Conclusão: O financiamento teve impacto positivo no aumento da realização de exames citopatológicos, contribuindo para a prevenção do câncer do colo do útero. No entanto, a implementação do programa enfrentou desafios como a desigualdade entre municípios, a falta de recursos e a necessidade de fortalecer a busca ativa por mulheres.
Prevenção e Controle do Câncer em Tempos de Capitalismo de Vigilância: Caminhos para o Combate à Desinformação
Authors: Lima Fernando Lopes Tavares de , Souza Telma de Almeida
Published: February 2025

Este artigo explora o papel emergente da infodemiologia no combate à disseminação da desinformação sobre câncer na era do capitalismo de vigilância. Aborda como esse modelo de negócio, ao maximizar o engajamento com conteúdo sensacionalista em mídias digitais, amplifica a infodemia e estimula a propagação de informações falsas, minando a confiança pública nas instituições de saúde e na ciência. A infodemiologia é apresentada como uma abordagem crucial para analisar padrões de disseminação de desinformação on-line, identificar fontes e temas prevalentes, e desenvolver estratégias baseadas na ciência. Defende-se que a infodemiologia oferece uma nova perspectiva para lidar com os impactos do capitalismo de vigilância e da infodemia, ao combater a disseminação de desinformação e apoiar políticas públicas informadas por evidências científicas.
Avaliação de Índices de Qualidade após Medidas Promovidas pelo Monitoramento Externo da Qualidade dos Exames Citopatológicos Cervicais Realizados pelo SUS no Espírito Santo
Authors: Dalvi Débora De'nadai , Cruz Ana Maria Gonçalves , Alves Lyvia Neves Rebello , Nodari Joana Zorzal , Goulart Jaqueline Pegoretti , Ribeiro Rodrigues Rodrigo
Published: February 2025

Introdução: Nas últimas décadas, apesar dos esforços do Ministério da Saúde para ampliar o acesso a programas de rastreio e monitoramento da qualidade dos exames citopatológicos, as taxas de morbimortalidade do câncer cervical no Brasil permaneceram altas. A persistência desses índices sugere falhas nos programas, provavelmente em virtude da baixa cobertura populacional, falhas no acompanhamento e erros no processo de coleta e interpretação dos exames. Para melhorar a prevenção e o rastreio do câncer cervical no Espírito Santo, a Unidade de Monitoramento Externo da Qualidade (UMEQ/Lacen-ES) implementou, em 2023, ações em parceria com os laboratórios que prestam serviço ao SUS. Objetivo: Avaliar o impacto dessas ações na qualidade dos exames citopatológicos. Método: O estudo comparou indicadores de qualidade dos exames obtidos por meio do SISCAN de 2023 aos cinco anos anteriores, assim como avaliou os indicadores de cada prestador entre o ano de 2022 e 2023. Resultados: Foram observadas melhorias significativas, como o aumento de diagnósticos de lesões precursoras e uma proporção de diagnósticos mais adequada, refletindo uma maior efetividade na prevenção do câncer cervical no Estado. Além disso, houve aprimoramento dos padrões de qualidade dos laboratórios ao longo do período. Conclusão: As ações implementadas pela UMEQ/Lacen-ES irão contribuir para a melhoria do rastreamento e prevenção da doença, embora seja necessário continuar investindo em novas tecnologias e na aplicação de protocolos para garantir agilidade e segurança no tratamento das pacientes.
Tendência da Mortalidade por Câncer do Colo do Útero em Campo Grande, Mato Grosso do Sul, 2000-2019
Authors: Macedo Geize Rocha , Cardoso Andrey Moreira , Pícoli Renata Palópoli , Mattos Inês Echenique
Published: February 2025

Introdução: O câncer do colo do útero (CCU) é o segundo câncer ginecológico mais comum no mundo. A análise da evolução da mortalidade por CCU permite detectar tendências negativas para a saúde pública e direciona estratégias preventivas. Objetivo: Analisar a tendência das taxas de mortalidade por CCU no município de Campo Grande, Mato Grosso do Sul, de 2000 a 2019. Método: Foi utilizado como fonte de dados o Sistema de Informação de Mortalidade e o Departamento de Informática do Sistema Único de Saúde e, para a análise, utilizou-se a regressão por JoinPoint. Resultados: Foi observada tendência decrescente das taxas de mortalidade por CCU em Campo Grande (APC = -3,12; IC 95%: -5,2 a -0,9). Em relação às taxas de mortalidade por idade, observou-se tendência decrescente para as faixas etárias de 50 a 59 anos (APC = -2,98; IC 95%: -5,7 a -0,2) e 60 a 69 anos (APC= -5,33; IC 95%: -9,1 a -1,4). Para as demais faixas etárias, a tendência foi estacionária. Conclusão: Apesar da tendência decrescente observada, as taxas de mortalidade por CCU apresentaram redução média anual de valor relativamente pequeno no período estudado, o que, associado à tendência estacionária observada para as taxas de mortalidade por porção não especificada do útero, pode indicar que o controle do CCU em Campo Grande permanece como um desafio para os gestores desse município.
Evolução do Tabagismo e Incidência de Câncer de Pulmão no Brasil (2000-2020)
Authors: Lima Fernanda Cristina da Silva de , Silva Darlan Henrique Nascimento da , Szklo André Salem , Scaff Alfredo José Monteiro , Reis Rejane de Souza
Published: February 2025

Introdução: O câncer de pulmão é uma das formas mais comuns de câncer e uma das principais causas de morte pela doença no mundo. O tabagismo, principal fator de risco, é responsável por cerca de 80% das mortes por câncer de pulmão no Brasil. Objetivo: O estudo visa apresentar informações sobre o tabagismo e a incidência de câncer de pulmão no Brasil, Regiões, capitais e Distrito Federal, estratificadas por sexo. Método: As informações sobre tabagismo foram obtidas de três principais fontes: a Pesquisa Nacional de Saúde (PNS) de 2019, a Pesquisa Nacional de Saúde do Escolar (PeNSE) de 2019, e o sistema Vigitel, com dados de 2006 a 2020. As taxas de incidência de câncer de pulmão foram calculadas a partir dos Registros de Câncer de Base Populacional (RCBP) no Brasil, de 2000 a 2019. As análises de tendência foram realizadas usando o modelo de regressão Joinpoint, com ajustes por idade e análises estatísticas conduzidas nos softwares Joinpoint, R e Epi Info. Resultados: No Brasil, a maior frequência de fumantes adultos foi encontrada entre homens (16%), com a Região Sul apresentando o maior percentual de adultos fumantes. Em geral, a incidência de câncer de pulmão diminuiu no período analisado nos homens, entretanto, ainda é observado um aumento nas taxas da doença na população feminina. Conclusão: Os resultados ressaltam a urgência de intensificar e ajustar as políticas de controle do tabaco, direcionando atenção especial para os jovens e as mulheres, a fim de preservar a saúde pública no Brasil.
Registros de Câncer de Base Populacional no Brasil: Relevância, Desafios e Oportunidades
Authors: Pena Gil Patrus , Santos Antonio Tadeu Cheriff dos , Pezzotti Camila Medeiros , Lima Carlos Anselmo , Daniel Cristiane Bastos , Laporte Cyntia Asturian , Veneziano Donaldo Botelho , Souza Dyego Leandro Bezerra de , Carvalho Flávia Nascimento de , Alencar Helenira Fonseca , Silva Janira Costa , Santos Jonas Eduardo Monteiro dos , Aquino Josefa Angela Pontes de , Loro Juliana Aparecida , Natívio Juliana , Oliveira Julio Fernando Pinto , Souza Leonardo Borges Lopes de , Formigosa Lucrecia Aline Cabral , Martins Luís Felipe Leite , Breda Maria Fernanda Regueira , Latorre Maria do Rosario Dias de Oliveira , Santos Maurício Marinho dos , Hora Michele Alcântara de Almeida da , Souza Paulo César Fernandes de , Ramos Neto Walmiro Ferreira , De Camargo Cancela Marianna
Published: February 2025

Dada a crescente importância do câncer como problema de saúde pública na população brasileira é necessário discutir as estratégias de vigilância do câncer a nível populacional. A complexidade da doença, englobando numerosos tipos de neoplasias, com características próprias, demanda medidas de enfrentamento dirigidas especificamente para cada tipo de câncer. Neste contexto, é necessário um sistema de vigilância próprio, em que os Registros de Câncer de Base Populacional (RCBP) assumem um papel fundamental, como a única estratégia capaz de fornecer informações fidedignas da incidência a nível populacional. Neste artigo, apresentamos a situação atual dos RCBP brasileiros, discutindo algumas vulnerabilidades e oportunidades para melhoria. Houve um avanço significativo nos RCBP nas duas últimas décadas, mas estamos em um momento delicado, que coloca em risco as conquistas já alcançadas. São necessárias medidas institucionais que valorizem a atividade do RCBP, a incorporação de novas técnicas de aquisição de informações, com coleta passiva de dados de diferentes sistemas e um embasamento legal consistente, que contemple a necessidade do uso da informação, tal como dispõe a Lei de Garantia e Proteção de Dados (LGPD), para garantir a qualidade de informação, a cobertura e sustentabilidade dos RCBP brasileiros.
Câncer Infantojuvenil do Sistema Nervoso Central: Reflexões para o Sistema Único de Saúde
Authors: Soares Luís Felipe , Gomes Júnior Saint Clair , Kuyven Nathália Grigorovski de Almeida
Published: February 2025

O presente artigo aborda a complexidade dos tumores do sistema nervoso central (SNC) em crianças e adolescentes, destacando o impacto significativo no Sistema Único de Saúde (SUS). Trata da epidemiologia desses tumores no Brasil, a carência de leitos de Unidades de Tratamento Intensivo Pediátricas (UTIP) e a concentração de centros especializados nas Regiões mais ricas do país. O texto discute a necessidade de diagnóstico precoce, a importância da capacitação das equipes de saúde, e a necessidade de políticas públicas para melhorar o acesso a tratamentos e apoiar as famílias afetadas. Além disso, o artigo explora a perspectiva de uso de novas tecnologias para melhorar o planejamento e a alocação de recursos no SUS.
Why is Mouth Self-Examination Still Not Recommended for Early Detection of Oral Cancer and Oral Potentially Malignant Disorders?
Authors: Silva Beatriz Monteiro da , Curvelo José Alexandre da Rocha , Barroso Ruteléia dos Santos Assumpção , Azevedo João Vitor Silveira de , Melo Andreia Cristina de , Cohen-Goldemberg Daniel
Published: February 2025

Oral self-examination still remains enigmatic considering its functionality in detecting malignant disorders in the mouth. Although this tool is not concretely implemented in any health service, several studies have considered it as a real possibility for the screening and the early diagnosis of oral cancer. However, the heterogeneity of the methodologies applied in these studies makes their results inconsistent and imprecise, making the validation of oral self-examination impossible to date. Thus, once the methodological issues that compromise the real efficacy of self-examination have been resolved, this tool should be used and perhaps be considered essential as a strategy to detect malignant lesions, contributing to more favorable outcomes for oral cancer in public health.
Obtenção de Estimativas de Sobrevivência ao Câncer no Brasil: Potencialidades e Desafios
Authors: Nagamine Camila Macedo Lima , Goulart Bárbara Niegia Garcia de , Moreira Priscilla Wolff , Rodrigues Laura Clezar , Ziegelmann Patrícia Klarmann
Published: February 2025

A vigilância do câncer envolve estratégias sistemáticas para monitorar indivíduos em risco e para identificar sinais precoces da doença, na perspectiva de melhorar os resultados clínicos e aumentar a taxa de sobrevivência. Os registros de câncer constituem uma ferramenta essencial para o controle do câncer, visto que medem a incidência e as tendências da doença, fornecendo indicadores para o planejamento para a avaliação das atividades de controle do câncer. Também, contribuem para a realização de pesquisas, conforme preconizado nas diretrizes do Sistema Único de Saúde. O texto discute os benefícios e desafios enfrentados pelos registros de câncer, destacando como esses desafios impactam a coleta e a utilização de dados essenciais para a pesquisa e análise de sobrevida. Observa-se que os registros populacionais enfrentam problemas como a falta de integração de dados e a necessidade de atualizar constantemente os sistemas para acompanhar novas informações e tecnologias. Já os registros hospitalares podem enfrentar desafios relacionados à consistência e à qualidade dos dados devido à variabilidade nos protocolos de coleta e documentação. Com este manuscrito, entendemos que é necessário melhorias na padronização dos dados e na colaboração entre instituições para superar esses desafios e para aprimorar a eficácia dos registros de câncer possa ajudar a maximizar o potencial dos registros para a pesquisa e sobrevida dos pacientes com câncer.
Análise Temporal e de Fatores Sociodemográficos da Mortalidade por Neoplasias da População Idosa no Brasil, no Período de 2011 a 2020
Authors: Souza Felipe Carneiro de , Carmo Cleber Nascimento do
Published: February 2025

Introdução: O aumento rápido da população idosa em países em desenvolvimento, aliado às mudanças no perfil epidemiológico, destaca a necessidade urgente de políticas públicas voltadas para a saúde do idoso. Objetivo: Analisar a mortalidade por neoplasias entre idosos no Brasil de 2011 a 2020, e sua relação entre alguns dados socioeconômicos. Método: Estudo ecológico. Foram calculadas taxas de mortalidade por neoplasias, padronizadas, e aplicados os modelos de regressão de Prais-Winsten, além de uma análise de agrupamentos. Resultados: Os resultados revelaram uma tendência crescente na mortalidade em todas as Unidades Federativas, com destaque para o Rio Grande do Sul e o Distrito Federal, que apresentou as maiores taxas médias. A análise de clusters identificou três agrupamentos distintos. Regiões com melhores condições socioeconômicas, como o Sul, apresentaram maior longevidade e, consequentemente, elevadas taxas de mortalidade por neoplasias. Por outro lado, as Regiões Norte e Nordeste, com piores indicadores, apresentaram menores taxas, possivelmente em razão de uma expectativa de vida mais baixa e de subnotificações. Conclusão: Esses achados ressaltam a necessidade de políticas públicas que melhorem o acesso à saúde e a qualidade dos cuidados para idosos em todo o Brasil.
Contradições entre Narrativas e Práticas dos Consumidores de Dispositivos Eletrônicos para Fumar
Authors: Perez Cristina de Abreu , Suarez Maribel Carvalho , Nascimento Thaysa , Tavares Luiza Novais , Prince Karina
Published: February 2025

Introdução: As políticas de controle do tabaco avançaram nas últimas décadas, entretanto a indústria do tabaco apresenta um novo desafio: os dispositivos eletrônicos para fumar. Objetivo: Mapear a percepção e as práticas de consumo dos consumidores jovens e adultos sobre os dispositivos eletrônicos para fumar, contribuindo com a reflexão a respeito da redução de danos. Método: Pesquisa qualitativa com grupos focais em cinco capitais de cada Região do país, com usuários entre 18 e 28 anos e adultos de 29 ou mais. Foram realizados dez grupos focais, com seis participantes em cada grupo, totalizando 60 informantes, pertencentes às classes A e B1, por meio da plataforma Zoom com roteiro semiestruturado de perguntas. Resultados: Os entrevistados parecem realizar uma “faxina simbólica” no tabagismo, restabelecendo significados dos cigarros convencionais, chegando à redução da percepção de risco, não se considerando fumantes. O produto é percebido como prático para utilização, com cheiro e sabor agradáveis, proporcionando socialização, sem tantas restrições para o seu uso. O trabalho também evidencia as barreiras de mensuração do consumo. A diversidade de modelos e a variedade de teores de nicotina parecem contribuir para uma ausência de parâmetros, comparativos e coletivos, dificultando a consciência do usuário sobre seu próprio consumo, além dos mecanismos de “flow”, em que o consumidor perde a noção do volume utilizado sem uma experiência material que sinalize uma unidade de consumo. Conclusão: As barreiras de mensuração de consumo e os mecanismos de “flow” parecem representar grandes riscos de ampliação do tabagismo.
Fim de Jogo para o Tabagismo no Brasil
Authors: Vosmirko Naira Milene Silva , Machado Alessandra Trindade , Vianna Cristiane Galhardo Ferreira , Mendes Felipe Lacerda , Pereira Renata Cristina Arthou , Carvalho Alexandre Octávio Ribeiro de , Teixeira Ana Paula Leal , Silva Vera Luiza da Costa e
Published: February 2025

O câncer de pulmão tem alta associação com o tabagismo e o tabagismo passivo, fato que levou essa doença, até então rara, a se tornar frequente décadas após a disseminação mundial do consumo de cigarros a partir da Segunda Guerra Mundial. Inúmeras doenças não transmissíveis e outros tipos de câncer também associados ao tabagismo se tornaram problemas de saúde pública. Para se contrapor aos efeitos danosos da exposição e ao consumo de produtos do tabaco, um tratado internacional foi adotado: a Convenção-Quadro da Organização Mundial da Saúde para o Controle do Tabaco (CQCT/OMS). Sua implementação permitiu uma redução do consumo de tabaco no mundo e no Brasil. No entanto, considerando além dos prejuízos à saúde, os danos adicionais ao meio ambiente e os custos crescentes associados ao tratamento das doenças tabaco-relacionadas, entre outros, começaram a ser discutidas e implementadas ações inovadoras que não foram previstas no próprio tratado. Assim, reduzir a prevalência do tabagismo entre adultos abaixo de 5%, por meio de estratégias denominadas tobacco endgame, o equivalente em português a "fim-de-jogo do tabaco", passou a ser uma meta. No Brasil, o alto nível de implementação da CQCT, aliado a uma prevalência de tabagismo próxima de 12% na população adulta, compõe um cenário favorável para viabilizar a aplicação dessas novas medidas. O fim-de-jogo do tabagismo no Brasil inclui o fortalecimento de medidas já implementadas, com maior rigor na sua fiscalização, acompanhados de medidas inovadoras que levem ao fim permanente da disponibilidade e da acessibilidade aos produtos fumígenos derivados de tabaco e nicotina.