bluuebunny/crossref_metadata_2025 huggingface dataset:
SAMUEL ANETSI AND CONTINUATORS THE CHRONICLE From Adam to 1776
Authors: MATEVOSYAN KAREN
Published: November 2022

Գիրքը ներկայացնում է 12-րդ դարի պատմիչ Սամվել Անեցու ժամանակագրությունը (Ադամից մինչեւ 1163 թ.), հետագայում կատարված ընդմիջարկություններով ու այն շարունակած հայտնի եւ անհայտ հեղինակների հավելումներով՝ հասնելով մինչեւ 1776 թվականը։ Պահպանվել են Ժամանակագրության 70-ից ավելի ընդօրինակություններ, որոնցից քաղվել են բազմաթիվ նորահայտ տեղեկություններ։ Նյութը ներկայացվում է ուսումնասիրությամբ եւ ծանոթագրություններով։
Ο προβληματισμός γύρω από την αποποινικοποίηση της χρήσης των ναρκωτικών στη Νορβηγία
Authors: Hauge Ragnar , Φασσουλάκης Γ.
Published: November 2022

Από τη δεκαετία του 1960 και μέχρι τα μέσα του ΄80, η Νορβηγία έμελλε να ξεχωρίσει ανάμεσα στα κράτη εκείνα της Δυτικής Ευρώπης με τη μεγαλύτερη κατασταλτική δραστηριότητα στο χώρο των ναρκωτικών. Πράγματι, κατά τη συγκεκριμένη περίοδο η μέγιστη ποινή που προβλεπόταν για αδικήματα περί των ναρκωτικών αυξήθηκε από τους έξι μήνες φυλάκισης που ήταν αρχικά, στα 21 χρόνια – μέγιστο όριο ποινής για οποιοδήποτε αδίκημα σύμφωνα με τη Νορβηγική νομοθεσία. Το τμήμα ναρκωτικών της αστυνομικής υπηρεσίας της πόλης του Όσλο διεύρυνε την αρμοδιότητα του, καλύπτοντας μεγαλύτερη περιφέρεια και αντικείμενα από οποιαδήποτε άλλη αστυνομική δύναμη πρωτεύουσας Ευρωπαϊκού κράτους. Εξάλλου, οι στοχευμένες τροποποιήσεις στη νομοθεσία και τα εκτελεστικά μέτρα της, άνοιξαν το δρόμο για νέες, ριζοσπαστικές μεθόδους έρευνας στο χώρο των αδικημάτων. Τίποτα δεν έπρεπε να αποτελέσει πρόσκομμα, στο δρόμο για την επίτευξη του απώτερου στόχου, που δεν ήταν άλλος από μια κοινωνία χωρίς ναρκωτικά. Οι χρήστες ναρκωτικών ουσιών αντιμετωπίζονταν ως αντικοινωνικοί εγκληματίες, υπεύθυνοι όχι μόνο για το μεγαλύτερο τμήμα των αδικημάτων που διαπράττονται, αλλά και για διάφορα άλλα κοινωνικά προβλήματα. Αυτό που εθεωρείτο ότι χρειαζόταν, ήταν η λήψη αυστηρών ποινικών μέτρων με σκοπό τον έλεγχο της απειλής.
Ομάδα Διαχείρισης Άγχους σε Τοξικοεξαρτημένα Άτομα - Πιλοτική Εφαρμογή του Γνωστικού Συμπεριφοριστικού Μοντέλου
Authors: Κωνσταντίνου Όλγα , Χαρίλα Ντιάνα
Published: November 2022

Στόχος: Η παρούσα έρευνα παρουσιάζει ένα ομαδικό πρόγραμμα διαχείρισης άγχους για τοξικοεξαρτημένα άτομα, το οποίο στηρίζεται στο γνωσιακό συμπεριφοριστικό μοντέλο, καθώς περιλαμβάνει τα πρώτα αποτελέσματα για την αποτελεσματικότητα του. Χώρος: Πρόγραμμα υποκατάστασης μεθαδόνης ΟΚΑΝΑ Πειραιά υπό την επίβλεψη του Ινστιτούτου Έρευνας και Θεραπείας της Συμπεριφοράς. Συμμετέχοντες: Μέλη του προγράμματος υποκατάστασης μεθαδόνης του ΟΚΑΝΑ Πειραιά, οι οποίοι κατανέμονται σε δύο ομάδες. Εργαλεία: Για τη μέτρηση κλινικών επιπέδων άγχους χρησιμοποιήθηκε το Symptom Checklist (SCL-90-R) (Derogatis, 1977). Μόνο άτομα με κλινικά επίπεδα άγχους κλήθηκαν να συμμετέχουν στην ομάδα. Πριν και μετά το τέλος της παρέμβασης δόθηκαν δυο αυτό-συμπληρούμενες κλίμακες: το Beck Anxiety Inventory (D. Beck & R. Steer, 1987) και το Symptom Checklist (SCL-90-R) (Derogatis, 1977) (Ντώνιας, Καραστεργίου, Μάνος,1991). Δομή: Η παρέμβαση περιελάμβανε ψυχοεκπαίδευση γύρω από το άγχος, παρουσίαση του γνωσιακού μηχανισμού του άγχους, το ρόλο της χρήσης ως μέσο αποφυγής, καθώς και εκπαίδευση στη διεκδικητικότητα, στρατηγικές αντιμετώπισης και δεξιότητες επίλυσης προβλημάτων. Η διάρκεια της παρέμβασης ήταν 13 εβδομάδες. Λέξεις κλειδιά: Διαχείριση άγχους, ομαδική γνωσιακή-συμπεριφοριστική θεραπεία, εξάρτηση από ψυχοτρόπες ουσίες, πρόγραμμα υποκατάστασης μεθαδόνης.
Πρόληψη μαθητικής παραβατικότητας στην πρωτοβάθμια εκπαίδευση: οι απόψεις δασκάλων, εκπαιδευμένων σε προγράμματα αγωγής υγείας, για την πρόληψη μαθητικών παραβατικών συμπεριφορών στο δημοτικό σχολείο και το ρόλο του δασκάλου σ’ αυτήν
Authors: Σμυρνάκη Μαρία
Published: November 2022

Στην παρούσα μελέτη γίνεται προσπάθεια να διερευνηθούν οι απόψεις δασκάλων, εκπαιδευμένων σε προγράμματα Αγωγής Υγείας, για την πρόληψη μαθητικών παραβατικών συμπεριφορών στο Δημοτικό σχολείο και το ρόλο του δασκάλου σε αυτή. Ειδικότερα, πρόκειται για ποιοτική μελέτη με ημι-δομημένες συνεντεύξεις σε 12 δασκάλους, εκπαιδευμένους στο πρόγραμμα Αγωγής Υγείας «Διαπροσωπικές Σχέσεις – Ψυχική Υγεία» από το Κέντρο Πρόληψης Δυτικής Θεσσαλονίκης «Δίκτυο Άλφα», με ενός τουλάχιστον σχολικού έτους εμπειρία σε οργανωμένες προσπάθειες πρόληψης στο Δημοτικό σχολείο. Σύμφωνα με τα αποτελέσματα της ανάλυσης, οι συμμετέχοντες εκπαιδευτικοί, στο σύνολό τους, παρουσιάζονται να είναι αρκετά εξοικειωμένοι με τις έννοιες της μαθητικής παραβατικότητας και της πρόληψης, να δίνουν ιδιαίτερη έμφαση στην ύπαρξη ανθρώπινων σχέσεων στο χώρο της εκπαίδευσης (μεταξύ των μαθητών, δασκάλων-μαθητών και δασκάλων-γονιών), να αναγνωρίζουν την ευθύνη των εκπαιδευτικών στην ανάπτυξη των παιδιών, να συνδέουν τον αποτελεσματικό στην πρόληψη εκπαιδευτικό με τον «καλό άνθρωπο-δάσκαλο», να τονίζουν την ανάγκη ύπαρξης ψυχολόγων στα σχολεία με ρόλο υποστηρικτικό/βοηθητικό στο έργο των εκπαιδευτικών και την ανάγκη ενασχόλησης του σχολείου και των εκπαιδευτικών με τις πραγματικές ανάγκες των παιδιών. Τα ευρήματα της έρευνας ουσιαστικά τονίζουν την ευθύνη του Δημοτικού σχολείου και του δασκάλου όσον αφορά την ψυχοκοινωνική ανάπτυξη των μαθητών. Λέξεις-Κλειδιά: μαθητική παραβατικότητα, πρωτοβάθμια εκπαίδευση, πρόληψη, ρόλος δασκάλου, σχέσεις στο πλαίσιο του σχολείου, ψυχοκοινωνική ανάπτυξη.
ANALISIS ASAM RETINOAT PADA KRIM PEMUTIH YANG BEREDAR DI E-COMMERCE KOTA JAKARTA
Authors: Pradika Yuri , Djasfar Seftiwan Pratami , Christiani Tesia
Published: November 2022

Krim pemutih merupakan produk yang berisi campuran bahan kimia atau bahan lainnya yang berkhasiat mampu memutihkan kulit atau memucatkan noda hitam (coklat) pada kulit. Salah satu bahan kimia yang menjadi komposisi krim pemutih yaitu asam retinoat. Senyawa ini dilarang penggunaannya dalam krim pemutih karena dapat menyebabkan kulit kering, rasa terbakar, dan teratogenik (cacat pada janin). Tujuan penelitian ini untuk mengetahui apakah krim pemutih yang beredar di e-commerce Kota Jakarta mengandung asam retinoat. Sampel krim pemutih yang diteliti sejumlah 7 sampel. Analisis kualitatif asam retinoat menggunakan metode Kromatografi Lapis Tipis (KLT) yang diamati di bawah sinar lampu UV 254 nm menunjukkan sampel B, C dan D positif mengandung asam retinoat.

Kata Kunci: Asam Retinoat, Krim Pemutih, Kromatografi Lapis Tipis
EFEKTIVITAS METODE EDUKASI PADA REMAJA TENTANG UPAYA PREVENTIVE INFEKSI MENULAR SEKSUAL DI SMK V KOTA MANADO
Authors: Kristine Dareda  , Berthina H. Korah
Published: November 2022

Berdasarkan hasil survey awal yanag dilakukan di SMK V Manado diketahui bahwa setiap tahunnya terjadi peningkatan angka drop out dikarenakan beberapa faktor diantaranya pergaulan bebas, dan hamil diluar nikah. Tujuan penelitian ini untuk mengetahui efektifitas inovasi metode edukasi  remaja  dalam upaya preventif  penyakit menular seksual ( pms ) /infeksi menular seksual (ims) di SMK V Manado. Metode yang digunakan yaitu pra experimental designs dengan pendekatan rancangan two group pretest posttest. Sampel dalam penelitian ini yaitu 40 responden dengan teknik pengambilan sampel Simple Random Sampling. Data dikumpulkan menggunakan kuisioner, selanjutnya diolah menggunakan SPSS dengan uji Statistik yaitu T-Berpasangan. Hasil dalam penelitian yaitu pada metode edukasi secara langsung nilai p=0.005 dan pada metode edukasi menggunakan media internet (whatsapp) nilai p=0.001. Kesimpulan edukasi secara langsung atau menggunakan media internet (whatsapp) masih efektif dilaksanakan.
DETERMINAN KARAKTERISTIK IBU DENGAN PENGGUNAAN KONTRASEPSI TRADISIONAL DI KELURAHAN PANDU KECAMATAN BUNAKEN KOTA MANADO
Authors: Ike Fitrah Atul Chabibah  , Nelawati Radjamuda
Published: November 2022

Latar belakang:Keluarga berencana (KB) rupanya sudah menjadi bagian dari kehidupan wanita di Indonesia. Buktinya, lebih dari separuh (57,4 %) jumlah wanita usia subur menggunakan KB.Distribusi pemilihan metode KB pada Wanita Usia Subur di PKM Bengkol kota Manado tidak BerKB 25,8 %, MKJP 29,8 dan Non MKJP 39 %. Hal ini menunjukkan bahwa tingginya angka WUS yang tidak berKB. Golongan yang tidak berKB bisa dikategorikan WUS unmeet Need, memakai Kb Tradisional sehingga tidak terdeteksi di Nakes, maupun yang ingin hamil.

Tujuan: Mengetahui determinan karakteristik dengan penggunaan kontrasepsi tradisional pada wanita usia subur.

Metode: Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross sectional dengan sampel para WUS yang menggunakankontrasepsiTradisional di Kelurahan Pandu. Besar sampel yaitu 31 orang. Pengambilan data dilakukan dengan wawancara menggunakan kuesioner. Data dianalisis dengan uji korelasi Spearman menggunakan SPSS versi 22 dengan nilai p

Hasil: Ada hubungan yang bermakna antara usia(p=0,047), paritas(p=0,030), pengetahuan (p=0,040) dan sikap (p=0,016) WUS dengan penggunaan kontrasepsi tradisional.

Simpulan:Hasil analisis Multivariat untuk melihat dominansi faktor karakteristik ibu terhadap Penggunaan KB tradisional menunjukkan bahwa dibandingkan dengan Umur, Paritas, Pengetahuan dan Sikap ibu, Sikap Wanita usia subur lebih tinggi nilai korelasi nya yaitu p value 0.035. Sehingga Hasil penelitian ini secara bermakna menunjukkan Faktor  yang dominan berhubungan dengan penggunaan KB tradisional pada WUS di Kelurahan Pandu Kecamatan Bunaken Kota Manado pada prodi DIII Kebidanan STIKES Muhammadiyah Manado adalah “ Sikap”.
Jewish–Muslim Interactions: Performing Cultures between North Africa and France, edited by Samuel Sami Everett and Rebekah Vince
Authors: Reeck Laura
Published: November 2022

Review of: Samuel Sami Everett and Rebekah Vince, eds. Jewish–Muslim Interactions: Performing Cultures between North Africa and France. Liverpool University Press, 2020. 382 pages.
Understanding and Analyzing Factors that Affect Merge Conflicts from the Perspective of Software Developers
Authors: Ribeiro Barbara Beato , Costa Catarina , Pereira dos Santos Rodrigo
Published: November 2022

Merge conflicts are very common in collaborative software development, which is supported mainly by the use of branches that can be potentially merged. In this context, several studies have proposed mechanisms to avoid conflicts whenever possible and some identified factors that lead to conflicts. In this article, we report on an investigation of factors that can lead to conflicts or that can somehow reduce the chances of conflict from the developers’ perspective. To do so, based on related work, we conducted two empirical studies with Brazilian software developers to both understand and analyze factors that affect merge conflicts. Firstly, we conducted survey research with 109 software developers to understand how they use branches, the occurrence of conflicts and the resolution process, and factors that can lead to or avoid conflicts. Results showed that the use of branches is very common and mostly has the purpose of creating a new feature or fixing a bug. According to the participants, in most projects, developers have the autonomy to create new branches and sometimes conflicts happen. The main factors that can lead to conflicts are “the time a branch is isolated” and “lack of communication”. On the other hand, the factors cited as good practices to avoid conflicts were “improve team communication” and “less branching duration”. Secondly, we conducted a field study based on interviews with 15 software developers to analyze those factors to understand better what leads to or avoids conflicts in a merge. Finally, this work allowed us to conclude that communication with the team, checking code updates, shorter branch duration, and management are important for software developers, especially when they think about what increases and decreases merge conflicts.
Sosialisasi Pemberdayaan Masyarakat Mengenai Pembuatan Denah Situasi Menggunakan Aplikasi AutoCAD di Desa Parereja, Kecamatan Banjarharjo, Kabupaten Brebes
Authors: Wahyu Mulya Wibowo  , Wahidin Wahidin , Muhammad Taufiq  , Wahudin Diantoro
Published: November 2022

Perkembangan teknologi di zaman sekarang yang sudah banyak menggunakan digitalisasi dapat membuat kemajuan pada banyak aspek terutama pada ketersediaan software gambar teknik yang dapat mendukung kegiatan pembuatan peta dan denah situasi. Aplikasi AutoCAD merupakan sebuah program yang biasa digunakan untuk tujuan tertentu dalam menggambar dan merancang dengan bantuan komputer dalam pembentukan model serta ukuran dua dan tiga dimensi atau lebih dikenali sebagai Computer Aided Drafting and Design Program (CAD). Selain adanya aplikasi untuk mempermudah pembuatan peta dan denah situasi ada juga yang namanya pemetaan yang merupakan suatu cara yang digunakan untuk mengenali kembali kondisi ruang yang sebenarnya dari suatu wilayah dan mendokumentasikan potensi sumber dayanya. Populasi pada kegiatan ini adalah perangkat desa dan pemuda karang taruna. Manfaat dari adanya pengabdian masyarakat yaitu melalui sosialisasi pembuatan peta atau denah situasi menggunakan AutoCAD. Hal ini sebagai bahan masukan bagi kantor balai desa untuk melakukan kerja sama dengan melibatkan masyarakat desa dan membuat masyarakat lebih mengenal program digitalisasi seperti pengenalan pada aplikasi AutoCAD. Adapun faktor penghambat ketika merealisasikan kegiatan Sosialisasi ini antara lain sulitnya mengatur jadwal peserta untuk melaksanakan sosialisasi. Keterbatasan media penyampaian materi dan sebagian besar peserta pelatihan tidak menggunakan laptop yang support sofware aplikasi.
Rozhovory v Komenském
Authors: Lojdová Kateřina , Horká Hana , Koldová Helena , Tomková Anna , Dundálková Karolína , Janík Tomáš , Šalamounová Zuzana , Bradová Jarmila
Published: November 2022

The book includes twelve interviews about pedagogical, curricular and didactic topics conducted with leading experts and important personalities in contemporary Czech pedagogy. It captures the ways of thinking about these issues in the second decade of the 21st century. It is intended for the wide professional public – academics, teachers and students.
Avances del Paraguay en el compromiso asumido por Ley 6657/2020 en el Marco de la Transparencia Fiscal Internacional
Authors: Cantero Fleita Carmen María
Published: November 2022

"Todas las jurisdicciones deben firmar y ratificar el Convenio multilateral sobre asistencia administrativa mutua en asuntos fiscales". El objetivo es presentar a través de un análisis los desafíos que debe alcanzar el gobierno nacional para evolucionar en el ámbito de fiscalidad internacional, considerando el intercambio de información, como elemento principal para la validación y verificación, además, de ser visto como país cooperante, cabe destacar, que hasta la entrada en vigencia de la normativa 6657/2020, no se vislumbraba para los demás países con esta definición. Se concluye que el compromiso político de la declaración está enmarcado en implementar estándares de intercambio información revisión de los pares además de contribuir con el fin con la financiación y el trabajo del foro global el fortalecimiento del marco legal operativo y organizativo para garantizar la disponibilidad y el acceso a la información relevante además del establecimiento de una red de intercambio de información la cual está en un proceso de adecuación y adaptabilidad a cada uno de los países de la región se prevé ayudar a los países a establecer y o mejorar la infraestructura necesaria para beneficiar las capacidades eficaces en el intercambio de información para mejorar la movilización de los recursos internos además con la implementación de estos estándares de intercambio de información se plantea implementación de marco legal establecer un marco adecuado de confidencialidad y protección de datos entre las administraciones tributarias además garantizar el uso eficaz de los datos todo esto hacia un desarrollo de capacidades con la finalidad de movilizar recursos internos y la lucha contra el lavado de activos un perfil de los países mejorados mayor seguridad jurídica para las empresas y el sector el financiero.
Lobbying as strategic communication in practice: The crown of the separatist movement on Kosovo and Metohija
Authors: Mitrović Miroslav , Perić Nenad
Published: November 2022

Strategic communication is one of the expressions of the soft power and represents an instrument in the political and security achievement of national interests. One of the strategic communication forms is lobbying. Potential lobbying of foreign policy is significant, as it could be realized through direct military intervention for support of interest group goals. The paper presents gained results of interest representation of Albanian interest groups regarding U.S. foreign policy as support of the achievement of the separatists' goal in the form of the Republic of Kosovo. Using content analysis and conclusions synthesis, the paper presents results that indicate effective and productive effects of applied interest representation strategy. It is a suggested that base of common interest should focus on political, economic and security interests, and institutional preconditions for effective lobbying of U.S. institutions. Conclusions indicate that organized and strategically planed lobbying approach to U.S. institutions can bring very good results.
Diálogos inter e intraconfessionais no século XVI como exemplos para uma pedagogia do diálogo contemporâneo
Authors: Dietz Martin Timóteo
Published: November 2022

O esforço ecumênico atual não pode ignorar tentativas – bem-sucedidas ou não – de diálogo realizadas no passado. Ainda que o movimento ecumênico moderno remonte ao início do século XX, já antes disso ocorreram tratativas tanto entre católicos e protestantes quanto entre representantes de diferentes correntes do protestantismo. A “comunhão dos santos” da qual fala o credo não é apenas sincrônica, mas igualmente diacrônica, englobando pessoas cristãs não somente de todos os lugares, mas também de todos os tempos. O texto visa auscultar tentativas de diálogo religioso (cristão) ocorridas no século XVI e perguntar por sua relevância pedagógica – positiva e negativa – para diálogos atuais.
Por que a guerra? Paradoxos entre violência, sofrimento e cuidado: atravessamentos entre Einstein, Freud e Etty Hillesum
Authors: Pavão dos Anjos Osni
Published: November 2022

O objetivo deste artigo é propor uma análise sobre o ser humano e suas ações numa abordagem social, psicanalítica e religiosa, partindo dos paradoxos entre violência, sofrimento e cuidado. Sabe-se que o ser humano é, por natureza, agressivo e capaz de causar sofrimento a si mesmo e ao próximo. Contudo, também é dotado de intelecto e ternura que o tornam apto para fazer escolhas em defesa da vida. Demanda-se questionar se haveria uma saída para essa realidade destrutiva que a humanidade carrega dentro de si. Para tanto, a análise parte do posicionamento da Psicanálise sobre as razões pelas quais o ser humano faz guerra, tema aprofundado no conteúdo abordado na carta “Por que a Guerra?” de Einstein e Freud, para chegar à análise do conteúdo do Diário de Etty Hillesum, uma judia que viveu e morreu nos Campos de Concentração. Do universal da humanidade ao sujeito particular, intenciona-se verificar se o ser humano, dotado de intelecto, mesmo em condições extremas em que a vida se encontre à beira da aniquilação, pode ser capaz de rechaçar o ódio e cultivar uma espiritualidade capaz de o mover para um caminho de pacificação.
Evaluation of Current Trends in Food Security
Authors: Kormishkin Evgenii Danilovich , Sausheva Oksana Sergeevna
Published: November 2022

The authors of the article investigate the current state and new trends in ensuring food security of subjects at various levels: from global to household level based on the application of an approach that includes the study of production aspects, economic availability of food, various components of the problem of food consumption, as well as the preservation of the current situation in the medium and long term. Special attention is paid to new factors affecting the state of food security: the growth of living standards in developed and some developing countries leads to increased requirements for the quality and safety of food; the new "green agenda" transforms agro-food systems towards greater sustainability. In the course of the study, diagnostics of the current state of food security was performed, as a result of which a number of certain negative trends were identified, among which: a decrease in the economic availability of food for the population of the Russian Federation as a whole, and especially for such individual groups as large families living in rural areas, families with disabilities, as well as families consisting of from unemployed pensioners. There is also a problem with an incomplete system for assessing the quality of food, as a result of which goods are falsified, the level of trust in public authorities decreases, and negative consequences for people's lives and health arise.
Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality
Authors: Sabharwal Ankit , Wishman Mark D , Cervera Roberto Lopez , Serres MaKayla R , Anderson Jennifer L , Holmberg Shannon R , Kar Bibekananda , Treichel Anthony J , Ichino Noriko , Liu Weibin , Yang Jingchun , Ding Yonghe , Deng Yun , Lacey Jean M , Laxen William J , Loken Perry R , Oglesbee Devin , Farber Steven A , Clark Karl J , Xu Xiaolei , Ekker Stephen C
Published: November 2022

The clinical and largely unpredictable heterogeneity of phenotypes in patients with mitochondrial disorders demonstrates the ongoing challenges in the understanding of this semi-autonomous organelle in biology and disease. Previously, we used the gene-breaking transposon to create 1200 transgenic zebrafish strains tagging protein-coding genes (Ichino et al., 2020), including the lrpprc locus. Here, we present and characterize a new genetic revertible animal model that recapitulates components of Leigh Syndrome French Canadian Type (LSFC), a mitochondrial disorder that includes diagnostic liver dysfunction. LSFC is caused by allelic variations in the LRPPRC gene, involved in mitochondrial mRNA polyadenylation and translation. lrpprc zebrafish homozygous mutants displayed biochemical and mitochondrial phenotypes similar to clinical manifestations observed in patients, including dysfunction in lipid homeostasis. We were able to rescue these phenotypes in the disease model using a liver-specific genetic model therapy, functionally demonstrating a previously under-recognized critical role for the liver in the pathophysiology of this disease.
m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site
Authors: Parker Matthew T , Soanes Beth K , Kusakina Jelena , Larrieu Antoine , Knop Katarzyna , Joy Nisha , Breidenbach Friedrich , Sherwood Anna V , Barton Geoffrey J , Fica Sebastian M , Davies Brendan H , Simpson Gordon G
Published: November 2022

Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon pairing with the conserved ACAGA sequence of U6 snRNA. In some species, including humans, the central adenosine of the ACAGA box is modified by N6 methylation, but the role of this m6A modification is poorly understood. Here, we show that m6A modified U6 snRNA determines the accuracy and efficiency of splicing. We reveal that the conserved methyltransferase, FIONA1, is required for Arabidopsis U6 snRNA m6A modification. Arabidopsis fio1 mutants show disrupted patterns of splicing that can be explained by the sequence composition of 5’ splice sites and cooperative roles for U5 and U6 snRNA in splice site selection. U6 snRNA m6A influences 3’ splice site usage. We generalise these findings to reveal two major classes of 5’ splice site in diverse eukaryotes, which display anti-correlated interaction potential with U5 snRNA loop 1 and the U6 snRNA ACAGA box. We conclude that U6 snRNA m6A modification contributes to the selection of degenerate 5’ splice sites crucial to alternative splicing.
SRSF6 balances mitochondrial-driven innate immune outcomes through alternative splicing of BAX
Authors: Wagner Allison R , Weindel Chi G , West Kelsi O , Scott Haley M , Watson Robert O , Patrick Kristin L
Published: November 2022

To mount a protective response to infection while preventing hyperinflammation, gene expression in innate immune cells must be tightly regulated. Despite the importance of pre-mRNA splicing in shaping the proteome, its role in balancing immune outcomes remains understudied. Transcriptomic analysis of murine macrophage cell lines identified Serine/Arginine Rich Splicing factor 6 (SRSF6) as a gatekeeper of mitochondrial homeostasis. SRSF6-dependent orchestration of mitochondrial health is directed in large part by alternative splicing of the pro-apoptosis pore-forming protein BAX. Loss of SRSF6 promotes accumulation of BAX-κ, a variant that sensitizes macrophages to undergo cell death and triggers upregulation of interferon stimulated genes through cGAS sensing of cytosolic mitochondrial DNA. Upon pathogen sensing, macrophages regulate SRSF6 expression to control the liberation of immunogenic mtDNA and adjust the threshold for entry into programmed cell death. This work defines BAX alternative splicing by SRSF6 as a critical node not only in mitochondrial homeostasis but also in the macrophage’s response to pathogens.
CAGE-ARCLIM cruise: Culturing (sub)Arctic planktic foraminifera Neogloboquadrina pachyderma and Globigerina bulloides: Implications for ocean acidification and paleoceanography reconstructions
Authors: Ezat Mohamed , Meilland Julie , Westgård Adele , Chalk Thomas , Sykes Freya , El Bani Altuna Naima , Nadar Pushpak , Tell Franziska , De la Vega Elwyn
Published: November 2022

From the morning of June 23rd to the morning of June 30th 2022, the Department of Geosciences at UiT the Arctic University of Norway, arranged a scientific cruise on R/V “Helmer Hanssen aimed at sampling living planktic foraminifera (Neogloboquadrina pachyderma and Globigerina bulloides) for culturing experiments both onboard and continued at the culturing laboratory at the Department. The purpose is to investigate the physiological and calcification responses of this species to a wide range of temperature, salinity and carbonate chemistry as well as to establish Arctic-tailored proxy calibrations for paleoceanography reconstructions
CAGE22-5 Cruise Report: High-resolution 2D and 3D seismic investigations on the Vøring Margin
Authors: Bünz Stefan , Planke Sverre , Singhroha Sunny , Lebedeva-Ivanova Nina , Binde Cornelia M. , Akinselure Abidemi Alex , Nagpal Umang , Wear Jonathan , Holm Truls , Jensen Stormer A.
Published: November 2022

The overall goal of this expedition was the acquisition of geophysical data on the Vøring Plateau and the southernmost part of the Lofoten Basin to improve the understanding of the subsurface structures and geological processes at four sites (U1571-U1574) where scientific drilling was recently successfully completed as a part of the the International Ocean Discovery Program (IODP) Expedition 396

The cruise may be known as: CAGE22_5
Linking parasitism to network centrality and the impact of sampling bias in its interpretation
Authors: Xu Zhihong , MacIntosh Andrew J.J. , Castellano-Navarro Alba , Macanás-Martínez Emilio , Suzumura Takafumi , Duboscq Julie
Published: November 2022

Group living is beneficial for individuals, but also comes with costs. One such cost is the increased possibility of pathogen transmission because increased numbers or frequencies of social contacts are often associated with increased parasite abundance or diversity. The social structure of a group or population is paramount to patterns of infection and transmission. Yet, for various reasons, studies investigating the links between sociality and parasitism in animals, especially in primates, have only accounted for parts of the group (e.g., only adults), which is likely to impact the interpretation of results. Here, we investigated the relationship between social network centrality and an estimate of gastrointestinal helminth infection intensity in a whole group of Japanese macaques (Macaca fuscata). We then tested the impact of omitting parts of the group on this relationship. We aimed to test: (1) whether social network centrality –in terms of the number of partners (degree), frequency of interactions (strength), and level of social integration (eigenvector) –was linked to parasite infection intensity (estimated by eggs per gram of faeces, EPG); and, (2) to what extent excluding portions of individuals within the group might influence the observed relationship. We conducted social network analysis on data collected from one group of Japanese macaques over three months on Koshima Island, Japan. We then ran a series of knock-out simulations. General linear mixed models showed that, at the whole-group level, network centrality was positively associated with geohelminth infection intensity. However, in partial networks with only adult females, only juveniles, or random subsets of the group, the strength of this relationship - albeit still generally positive - lost statistical significance. Furthermore, knock-out simulations where individuals were removed but network metrics were retained from the original whole-group network showed that these changes are partly a power issue and partly an effect of sampling the incomplete network. Our study indicates that sampling bias can thus hamper our ability to detect real network effects involving social interaction and parasitism. In addition to supporting earlier results linking geohelminth infection to Japanese macaque social networks, this work introduces important methodological considerations for research into the dynamics of social transmission, with implications for infectious disease epidemiology, population management, and health interventions.
Research on the Innovation of Online Education and Teaching Mode in Colleges and Universities Under the Background of "Internet +"
Authors: Junjing ZHAO
Published: November 2022

Research on the innovation of online education and teaching mode in colleges and universities under the background of "Internet +" is presented in the paper. As far as the modernization of the ideological and political education in the value dimension is concerned, the purpose of studying its ought state is to examine the value or ideal goal of the modernization of ideological and political education. With this idea, this paper will then propose the innovation of online education and teaching mode in colleges and universities under the background of "Internet +". The intelligent models are presented and the detailed discussions are studied.
Turismo e tecnologia da informação
Authors: Kuss Ana Carolina , Medaglia Juliana
Published: November 2022

O presente artigo refere-se à importância das transformações digitais no setor de turismo e suas contribuições para o desenvolvimento das agências de viagem na era do Turismo 4.0, a nova revolução tecnológica que alterou o comportamento do consumidor. A relação entre turismo e tecnologia é histórica, sendo assim, apresentamos no desenvolvimento essa relação entre ambos para, em seguida, discutirmos o conceito de agenciamento de viagens até o entendimento das travel techs, as novas aplicações de soluções de TI e comércio eletrônico no contexto do mercado de turismo, transformando o antigo mercado do agenciamento.
Genetic Analysis of Morpho-metric Traits and Correlations of Yield Parameters in Soybean (Glycine max L. Merr)
Authors: Ibirinde D. O. , Kolawole A. O. , Aremu C. O. , Balogun K. , Iliya M. N. , Angyu J.
Published: November 2022

Top crosses comprising 2 testers and 8 lines were made in the screen house using Line × Tester model. Observations were made on days to flowering, pod maturity, harvest, pods per plant, branching pattern, seeds per pod, 100 seed weight and yield/ha; crude protein, crude fiber, carbohydrate, moisture, ash and oil, as well as trypsin, tannins and phytate. Data collected were subjected to Analysis of Variance and the means separated using Duncan Multiple Range Test (DMRT), at 5% probability level. Genetic component analysis was carried out on the traits using Analysis of Genetic Design (AGD-R) package, to determine heritability, General Combining Ability (GCA) and Specific Combining Abilities (SCA). Results of the study revealed that, positive GCA values were recorded by TGM954 (0.01), TGM120 (0.07), TGM553 (0.70), TGM555 (0.58), TGM574 (0.19), TGM584 (0.14) and TGX1904-6F (0.12) for 100 seed weight; TGM954 (76.83) and TGM584 (12.54) for seed yield. Generally, TGM954 was a better general combiner than TGM951, because it combined well with other varieties for yield and yield-related traits. High heritability estimates were recorded for 100 seed weight (84.10%), number of branches (86.61%), days to flowering (91.69%), pods per pod (88.48%) and seed yield (86.07%). It can be concluded, that, crosses using Line × Tester model is encouraged for trait transfer and enhancement of soybean seed yield.
Factors Associated with the Extent of Usage of Accounting Information by the Public Accounts Committee in Tanzania Public Corporations
Authors: Kyando Asifiwe Enock , Abayo Abdiel , Raphael Gwahula
Published: November 2022

This study aims to examine expectations on content of accounting information and ability to interpret accounting information as associated factors on the extent of usage of accounting information in Tanzania public corporations. The usage of accounting information by politicians in the world context have led to mixed results.Further, the use of accounting information by Public Accounts Committee (PAC) in monitoring public corporations has not been consistent, hence calling for an examination on the practice to get insights explaining the extent of usage of accounting information. Data for the study were gathered using a survey instrument from Public accounts committee members and ex-members from 2005 to 2022. The study used Partial Least Square Structural Equation Modeling [PLS- SEM] to analyze data. Findings reported coefficient determination (R2) of 0.640 that explained a 64% variation in the extent of usage of accounting information as a dependent construct. The study found that expectations on content of accounting information and ability to interpret accounting information were positively and statistically significant as factors associated with the extent of usage of accounting information in Tanzania public corporations. Thus, the study strongly recommends to the Parliament, Regulators, practitioners, and other relevant stakeholders, to consider the findings of this study to enhance the extent of usage of accounting information. This can be done through crafting and implementing policy making for usefulness of accounting information driven by the Public Accounts Committee needs. Besides, the producers of accounting information must ensure accounting information possesses a quality, relevance, and appropriateness to influence the ability to interpret accounting information and meet expectations on content of accounting information, hence improving the extent of usage of accounting information in Tanzania public corporations.
Corporate Mergers, Acquisitions and Value Creation of Firms in Nigeria
Authors: Abode Josephine Olohije , Igbinosa Sunday Osaretin
Published: November 2022

This study seeks to scrutinize the effect of corporate mergers, acquisition and value creation of firms in Nigeria and to identify areas of synergy. The study employed secondary data collected from the bank’s annual report. The data collected covered a period of fourteen years, which is divided into the pre and post-merger periods of seven years respectively. The study adopted panel least square estimation technique and other estimation for the analysis. The study finds out that shareholders’ funds and earnings per share are significant in determining the return on asset. Also shareholders’ funds and total asset values are statistically significant in the pre-merger periods in determining return on asset. That profit after tax is statistically significant in explaining financial efficiency in the pre-merger periods; the study concludes that there was increase in the shareholders’ funds for the post-merger periods.
Impact of Abattoir Activities on the Physicochemical and Bacteriological Properties of Soil Samples from Choba Slaughter, Rivers State, Nigeria
Authors: Sampson T. , Deele R. D.
Published: November 2022

Slaughtering and processing of animal products at abattoirs generate different waste that may be transported into the nearby water bodies through runoff and other processes. Evaluating the soil characteristics within the abattoir will provide critical information regarding the soil health, for environmental management and health care planning. The aim of the study was therefore to assess the impact of abattoir activities on soil physico-chemical and bacteriological properties. The soil sampling involved five (5) different points, representing regions where the live animals were kept, where the animals were slaughtered, where the animal hides were roasted, where the waste bones were stacked, and a control sample collected 20 meters away from the abattoir site. The result of the physicochemical parameters showed that all the sample points were either higher or lower than that of the control soil sample. Statistical analyses however showed that there was a statistically significant difference (p < 0.05) between the nitrate concentration in the region used for roasting of animal hides and the control sample.  The result of Total Heterotrophic Bacterial Count (THBC) showed that the highest value of 7.2 x 108cfu/g was obtained from the location where the animals are slaughtered, while the least value of 1.0 x 108 cfu/g was from the control soil sample. The other bacterial counts varied between 0.8x105 cfu/g and 5.0 x 106 cfu/g; 4.3 x104 cfu/g and 1.0 x105 cfu/g; 3.7x104 cfu/g and 5.6x104 cfu/g, for  the Total Coliform Count (TCC), Fecal Coliform Count (FCC), Salmonella and Shigella Counts (SSC), respectively. A total of 28 bacterial isolates were characterized and identified to belong to seven genera, and their percentage prevalence showed that Staphylococcus spp., Bacillus spp., and E. coli were the most occurring, with a frequency of 21.7% each, followed by Salmonella spp. (13.1 %), Klebsiella spp. (8.7 %), Serratia mercescens (8.7 %) and  Shigella spp. (4.4 %). The result of the response of the bacterial isolates to the conventional antibiotics revealed that all the isolates where sensitive to most of the antibiotics tested. This study has shown that abattoir activities have significant influence on the bacteriological and physicochemical characteristics of the soil, thereby accentuating the need for proper waste management.
Characterization of Spirogyra sp. Using Thermogravimetric/ Derivative Thermogravimetric (TG/DTG) Analysis and Bomb Calorimeter for Energy Application
Authors: Kumar Rupesh , D’Souza P. M.
Published: November 2022

Biomass is usually considered as different types of lignocellulosic materials having varied composition potential to utilize in the useful forms of energy as a substitute of conventional fossil fuels. Algal biomass has multi facet application in research and development such as source of nutrients,  biochemical,  cosmetics  and biofuels. However, this newly developed energy source met the requirement of low and medium scale power generation due to low thermal efficiency. In present study, freshwater algae Spirogyra sp. taken as source of biomass and analyzed for Thermogravimetric (TG) and calorific values analysis. We found the calorific value is 2129.4 Kcal/Kg and TGA results show that algal biomass decrease rapidly after reaching the temperature over 300°C. The result obtained in this paper may be used in future as reference material for algae based biomass for energy application.
Efficacy of Environics Color Slides in Detecting the Color Deficiency and Healing
Authors: Somanadhapai Sangeeth , Shah Pooja Nirmal , Yepthomi Tokika , Rana Sunita , Matanhelia Manisha
Published: November 2022

Chromotherapy, also called Color Therapy or Visible Range Radiation Therapy, is a non-pharmacological therapeutic modality that uses various wavelengths of electromagnetic radiation from within the visible spectrum (colors).

Methods & Materials: The study was performed on 65 healthy participants from SGT University, Gurgaon, India. Full, free, and voluntary informed consent was obtained from all subjects and/or their legal guardian(s). Colour deficiency was diagnosed with the help of Environics Colour Slides and an Instrument called Lecher Antenna which works on the principle of resonance. The diagnosis results obtained from color slides and Lecher Antenna, (SBJ International, PARIS) were compared with the results obtained from the Es- Teck Complex, (LD Technology™, US) an FDA-approved Medical Software and Machine.

Results: It was observed that 86.11% of participants showed improvement in their health conditions after using the Environics Colour Slides for the period specified during the diagnosis. It was also observed that there was an 87.69% correlation between the findings of the Environics Colour Slides / Lecher Antenna combination and the ES-Teck Medical Software in identifying the health condition of the participants.

Conclusion: Chromotherapy will greatly benefit from this evidence base and help propagate this alternative treatment modality for the safe, and non-pharmacological treatment of many diseases [5].
Formação continuada transformadora com docentes alfabetizadores que ensinam matemática
Authors: Thees Andréa , Carneiro Abrahão Ana Maria , Akio Yokoyama Leo
Published: November 2022

Este relato apresenta reflexões sobre o desenvolvimento do curso “Alfabetização matemática para docentes do 3º ano do Ensino Fundamental”, uma ação do Projeto de Extensão “Formação Matemática para Docentes dos Anos Iniciais”. Tal projeto está ancorado no Grupo de Estudos e Pesquisas em Educação Matemática, EDMAT/Unirio. Tivemos por objetivo discutir com docentes cursistas metodologias de ensino e de aprendizagem matemática, bem como formas de avaliação envolvendo elaboração de portfólios. Na metodologia, baseada na resolução de problemas, procuramos aprofundar conteúdos curriculares, conceituais e didáticos explorando a relação teoria e prática em sala de aula. Entre os resultados dessa ação de extensão, observamos a possível reconstrução de uma pequena, mas representativa, comunidade docente que vivenciou práticas coletivas de reflexão e investigação da sua própria ação profissional. Observamos, ainda, a evolução da comunicação de suas produções textuais feitas e refeitas em formas de portfólios. Esperamos que esse relato traga contribuição para outras experiências de formação continuada extramuros.
Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
Authors: Wang Zhenqian , Lu Jiawen , Weng Weipin , Zhang Li , Zhang Jie
Published: November 2022

Objective

We conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment (EA)) in these associations.

Methods

Using summary‐level data from large‐scale genome‐wide association studies, we performed univariable MR to examine whether there is genetic evidence that women's reproductive traits are causally associated with IS and its subtypes. Multivariable MR and MR mediation analysis were used to investigate whether BMI and EA are common mechanisms or mediators for these associations. A set of sensitivity analyses were conducted to test valid MR assumptions.

Results

We observed consistent and statistically significant associations across female and sex‐combined analyses for earlier age at first birth (AFB) and age at first sexual intercourse (AFS) with a higher risk of IS and large‐artery atherosclerotic stroke (LAS) risk in the primary analysis. The odds ratios of IS per 1 SD increase in genetically predicted early AFB and AFS were 0.93 (95% CI, 0.86–0.99; p = 0.046) and 0.83 (95% CI, 0.70–0.97, p = 0.020), respectively. Further analyses indicated that BMI played a shared role in AFS and IS/LAS while EA played a shared role in AFS/AFB and IS/LAS as well as a mediator in the path from AFS to IS/LAS.

Interpretation

These findings may inform prevention strategies and interventions directed toward relative women's reproductive behaviors and IS. Future studies are warranted to explore other factors related to EA which are responsible for these causalities.
Microstructure and Hardness of an Al–8 wt%Si–2.5 wt%Bi Alloy Subjected to Solidification Cooling Rates from 0.1 to 800 K s−1
Authors: Dias Marcelino , Bogno Abdoul Aziz , Spinelli Jose Eduardo , Oliveira Ricardo , Cheung Noe , Garcia Amauri , Henein Hani
Published: November 2022

This work explores the effect of the addition of bismuth (Bi) to Al–8 wt%Si alloys. Bi in Aluminum based alloys works as a self‐lubricating agent, improving machining and wear properties. As Bi is a soft material, it is essential to evaluate how it affects microstructural features and the resulting properties of Al–8 wt%Si alloys. Herein, this hypoeutectic alloy is modified by the addition of 2.5 wt%Bi and subjected to three solidification techniques: differential scanning calorimetry, transient directional solidification, and impulse atomization. Thus, this work investigates the effect of Bi in samples solidified under a wide range of cooling rates. Of specific interest is how Bi modifies the eutectic silicon morphology and alloy hardness compared with a hypoeutectic Al–10 wt%Si alloy from the literature. The silicon (Si) morphology of Al–8 wt%Si–2.5 wt%Bi transitions from flaky (coarse) to fibrous (fine) at a critical cooling rate of 1100 K s−1. Through the combination of Bi addition and processing through impulse atomization, the ternary Al–Si–Bi alloy achieves improvements in hardness of up to 20% compared to Al–10 wt%Si. This is despite having a coarser eutectic microstructure than the binary hypoeutectic Al–Si alloy. This is due to Bi modifying the morphology of the eutectic Si.
A Bioinspired Triple‐Hierarchical Superhydrophobic Surface with Exceptional Robustness to Water Impingement
Authors: Chung Soochan , Riley Cameron , Taylor Hayden
Published: November 2022

Bioinspired surfaces have great potential for self‐cleaning, condensation acceleration, and drag reduction. However, manufactured biomimetic surfaces typically feature only one or occasionally two length scales of surface topography and do not fully recapitulate the structure and function of natural textures. Herein, a triple‐hierarchical superhydrophobic surface (TriSS) inspired by water‐repellent lotus leaves is introduced, which consist of arrays of microprotrusions with various sizes, grooves between the protrusions, and a covering of nanoscale hairs. The TriSS surface is manufactured by forming an array of microdomes through photolithography and thermal reflow. These microstructures are transferred, by casting, to an elastomer, which is then augmented with surface wrinkles by the relaxation of biaxial stress in an oxidized surface layer. Conformal growth of a nanoporous zinc oxide film and fluorosilanization adds further surface detail. The TriSS surface achieves a sessile water contact angle up to 174.3 ± 0.3° and contact angle hysteresis down to 9.9 ± 0.3° via the very limited liquid–solid contact enabled by the surface topography. The surface also captures and retains a stable air layer, which resists water impingement even when submersed to 20 cm depth for more than 200 h. The TriSS process offers a scalable route to water repellence in industrial applications.