bluuebunny/crossref_metadata_2025 huggingface dataset:
Monogenec Arrhythmic Syndromes: From Molecular and Genetic Aspects to Bedside
Authors: Golukhova E. Z. , Gromova O. I. , Shomahov R. A. , Bulaeva N. I. , Bockeria L. A.
Published: June 2019

The abrupt cessation of effective cardiac function that is generally due to heart rhythm disorders can cause sudden and unexpected death at any age and is referred to as a syndrome called sudden cardiac death (SCD). Annually, about 400,000 cases of SCD occur in the United States alone. Less than 5% of the resuscitation techniques are effective. The prevalence of SCD in a population rises with age according to the prevalence of coronary artery disease, which is the most common cause of sudden cardiac arrest. However, there is a peak in SCD incidence for the age below 5 years, which is equal to 17 cases per 100,000 of the population. This peak is due to congenital monogenic arrhythmic canalopathies. Despite their relative rarity, these cases are obviously the most tragic. The immediate causes, or mechanisms, of SCD are comprehensive. Generally, it is arrhythmic death due to ventricular tachyarrythmias - sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). Bradyarrhythmias and pulseless electrical activity account for no more than 40% of all registered cardiac arrests, and they are more often the outcome of the abovementioned arrhythmias. Our current understanding of the mechanisms responsible for SCD has emerged from decades of basic science investigation into the normal electrophysiology of the heart, the molecular physiology of cardiac ion channels, the fundamental cellular and tissue events associated with cardiac arrhythmias, and the molecular genetics of monogenic disorders of the heart rhythm (for example, the long QT syndrome). This review presents an overview of the molecular and genetic basis of SCD in the long QT syndrome, Brugada syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and idiopathic ventricular fibrillation, and arrhythmogenic right ventricular dysplasia, and sudden cardiac death prevention strategies by modern techniques (including implantable cardioverter-defibrillator).
“健康中国”视阈下高职院校学生心理健康教育体系构建的路径探析
Authors: 于 舒 , 李 志芳
Published: June 2019

在“健康中国”这个大背景下，“健康校园”的建设成为其中的重要组成部分，随着改革开放的深入发展，多层次、多元化人才的需求变大，更需要人才具备强大的心理素质来应对多变的竞争环境。而对于高职院校学生来说，更加面临着严峻的就业和创业挑战，作为人才培养的重要阵地，高职院校要积极探索学生心理健康教育体系构建的基本路径。本文通过研究分析高职院校学生心理健康教育体系构建的重要意义，以及心理健康教育体系现状，提出高职院校学生心理健康教育体系构建的基本路径。
基于人本主义的城市发展理论探讨
Authors: 栾 阿诗
Published: June 2019

本文在搜集资料的基础上,以时间为序,对人本主义的城市发展理论进行了总结,并着重对现代的城市规划思想进行了介绍,试图梳理人本主义思想的发展脉络及其对于城市发展的影响,以期为当代国内城市规划提供借鉴。
创新高等职业教育教材出版的对策探究
Authors: 赵 部
Published: June 2019

随着高等职业教育由规模化增长逐步转为内涵式发展,高等职业教育教材(以下简称高职教材)出版中的问题渐渐凸显。本文在对高职教材出版中存在问题分析的基础上,明确了高职教材出版应遵循的原则,并以大连理工大学出版社(以下简称大工社)的探索与实践为例,对教材建设的创新发展模式进行了探究。
Mooc+Sopc平台下大学计算机基础课程综合改革研究
Authors: 卢 光云 , 周 耿铭
Published: June 2019

本文针对我校向应用技术型大学转型过程中,基于Mooc+Sopc平台下对大学计算机基础课程进行研究,围绕课程考核方式及内容改革研究,在线考试平台对课程进行小节测试,根据测试的知识点进行统计分析,更好地反映出在慕课教学模式下学生的掌握知识情况,同时也是对慕课平台教学模式的过程评价的研究。
复杂工程问题在自动化专业本科教学中实施方案探讨
Authors: 高 瑜 , 陈 良
Published: June 2019

培养本科生解决复杂工程问题的能力是工程教育认证的核心关注点之一。针对国内先进制造业的人才需求并结合自动化专业教学的特点,本文以“自动化产线的设计、集成和控制”作为复杂工程问题的载体,并按照OBE(Outcome-BasedEducation)的理念构建相关的课程体系,配合系统的、可操作的教学过程,重点突出复杂工程问题“综合、实践与创新”的特点,探索达成自动化专业培养目标的有效方法与途径。
课题中心教学法理论下的韩语会话课教学模式构建
Authors: 周 晗
Published: June 2019

本文是以课题中心教学法的理论为背景,探讨了如何使学生在韩语会话课上能够积极主动参与学习而提出一些讲授方案建议以及对于实际课堂中如何运用角色扮演的方式进行韩语会话课的研究提出一些课堂教学模式构建。
高职机械类专业机械制图教学改革模式的相关分析
Authors: 冯 琴
Published: June 2019

在高职的机械类专业课程学习中,机械制图是学生需要重点掌握的内容。机械制图是机械工程的语言,对于不管对以后要从事机械设计、机械制造、机械维修等多方面的行业,都需要用到机械制图。为了能够有效提高机械类专业学生的制图能力,那么加强高职高职机械类专业机械制图的教学改革是非常有必要的。因此,本文对高职机械类专业机械制图教学改革模式做了一些相关分析。
“非暴力沟通”策略在班级管理中的运用
Authors: 翟 燕
Published: June 2019

如何用非暴力语言表达教育的目的、如何在班级管理中不吼不叫还能取得显著的教育成效、如何说孩子才会听,怎么听孩子才肯说,这都是本文探讨的地方,希望个人的实践经验为班主任提供可借鉴的沟通策略。
校企合作搭建良好实践教育平台探索
Authors: 雷 劲松 , 简 斌
Published: June 2019

当前高校进行教学实践与探索是为了培养能够更好的适应社会需要的卓越人才的迫切要求。随着中国高等教育从精英教育向大众教育的转变,使高校面临着实习实践环节资源短缺的困境,导致毕业生动手能力逐渐与社会脱节。如何培养具有专业知识和实践能力的卓越人才,近年来各高校以创新视角审视这些问题并不断改革。本文探索通过校企合作共同搭建实践育人平台,为高校师生提供丰富的实践教学资源,同时也为企业的产业升级和经济社会的可持续发展提供足够的后备人才。
园林绿化工程春季的养护与管理
Authors: 魏 子莫 , 魏 文典
Published: June 2019

在园林绿化工程建设和发展过程中,工程养护和管理是其中最重要的工作内容之一,而春季又是工程养护与管理的关键时期,其不仅是集中调控园林绿化工程花草树木的成活率的关键环节,同时也是提升园林绿化工程质量和园林景观的整体控制水平的重要保证。因此,相关人员需高度重视工程的春季养护和管理,并掌握工程春季养护和管理的方法,才能推动园林绿化工程建设取得更好、更快的发展。本文主要简析了园林绿化工程养护与管理的重要性,并总结了园林绿化工程春季的养护与管理的方法,以期能为后续园林绿化工程养护和管理提供有效的参考。
项目教学：培养中职生工匠精神的有效路径
Authors: 冯 岩
Published: June 2019

本研究通过对工匠精神在服务行业内涵的提炼,构建“四个维度十大要素”工匠精神内容框架,结合中职生教育实际,以项目教学为基本路径,通过学生学习、生活中可见式量化,打磨生成“工匠精神”行为标准模式,打造校园、班级、课堂三个训练平台,形成全方位可持续养成机制,在日常的学习生活中逐步变成“小工匠”。
巧管理真高效——浅谈中学班主任管理艺术
Authors: 于 海彬
Published: June 2019

本文以中学班主任的管理艺术作为主要分析和论述对象,结合当下的中学管理中存在着的若干问题展开分析。中学班主任应该以一种高屋建瓴的视野,谋划全局,以高度的责任心来负责班级内学生们的课堂活动和学习游戏,同时也要分析好学生们的内在心理,做到对症下药,以巧妙的管理方式实现高效的管理效果。本文将对中学班主任们的管理艺术展开进一步的研究和探讨。
“强化学校体育”目标下的体育教学控制及实施策略研究
Authors: 于 华 , 何 兵雄
Published: June 2019

对“强化学校体育”目标下的“体育教学”进行研究,认为体育教学过程控制是实施素质教育、实现中华民族伟大复兴的中国梦的重要基础。文章得出体育教学的控制和实施策略主要为：控制教学成本,强化经济投入；控制教师质量,强化教师水平；控制好学生兴趣,强化教学引导；控制教学过程,强化效果落实；控制教学评测,强化阶段对接。
Spanish (proper noun-head) pseudorelatives: a corpus-based study of frequency
Authors: Aldama García Nuria , Moreno Sandoval Antonio
Published: June 2019

Pseudorelatives (PRs) have been studied from syntactic and semantic perspectives for decades. The literature contains explanations regarding PRs internal structure, the way PRs relate to the matrix predicate, the position PRs can occupy within the matrix clause and the role the head of the PR plays within the embedded clause. PRs processing and attachment have also been studied from diverse psycholinguistic views. However, there is no corpus-based study showing the actual frequency of use of PRs or the register (i.e. written or spoken texts, genres) where these structures are more commonly found. The goal of this paper is to study the frequency of use of a subtype of PRs, namely Spanish PRs having a proper noun within the DP head and the varieties of Spanish where they appear. To do so, two different search patterns based on the most salient syntactic properties of PRs were built up and applied to CORPES XXI. The results extracted from this research process point towards three main ideas. This subtype of PRs is a very low frequency structure in Spanish, texts from the Chilean and the Mexican and Central American linguistic areas contain the highest frequency values and this subtype of PRs is only registered in written texts up to the moment.
Patient Satisfaction and Body Image Following Mastectomy, Breast-Conserving Therapy, and Mastectomy With Reconstruction: A Study in Iran
Authors: Olfatbakhsh Asiie , Haghighat Shahpar , Tabari Mohammadreza , Hashemi Esmat , Sari Fateme , Kaviani Ahmad
Published: June 2019

Background: Breast cancer is considered a chronic disease owing to the increases in survival rate. Thus, better body image and patient satisfaction with the surgery have become more important factors to be considered when choosing the surgical approach. The aim of this study was to compare body image and patient satisfaction following three different approaches.

Methods: We evaluated 183 consecutive patients who had undergone three different surgeries including breast-conserving surgery (BCS), mastectomy, or mastectomy followed by reconstruction (M-R). Body image was evaluated using the BICI questionnaire, and patient satisfaction was rated using a multiple-choice question and a scale ranging from 1 to 10.

Results: A significantly better body image was observed in the M-R and BCS groups compared with mastectomy (P = 0.02). In body image subscale analysis, social functioning scores were higher in the M-R and BCS groups than in the mastectomy group (P = 0.01), but no differences were obtained between surgery groups in appearance dissatisfaction subscale. Patients were more satisfied with BCS than the other two surgeries (P = 0.008).

Conclusion: Based on the results of this study, it could be proposed that both oncoplastic BCS and implant reconstruction could provide patients with acceptable body image, while BCS could bring about better satisfaction with the surgery. Reconstruction may be an alternative for the patients to improve body image and satisfaction when BCS is not applicable.
Warfarin Induced Necrosis of The Breast: A Case Report
Authors: Zand Sanaz , Jalili Roghayye , Emami Razavi Seyed Hasan , Najafi Massoome , Kaviani Ahmad
Published: June 2019

Background: Warfarin induced breast necrosis is a rare complication of oral anticoagulant therapy. Although it can be related to protein C, S, and antithrombin III deficiency; the pathogenesis of necrosis is still unknown.

Case presentation: We report a case of a 38-year-old woman with extensive left breast necrosis after receiving warfarin for treatment of deep vein thrombosis. Simple mastectomy was performed and the wound was closed secondarily with an abdominal advancement flap. Rivaroxaban was prescribed after discontinuation of warfarin.

Conclusion: Although breast necrosis following warfarin usage is uncommon, it should be considered in women presenting with breast symptoms after initiation of warfarin. Early diagnosis and appropriate management are essential to prevent extensive loss of breast tissue.
Game Studies: Entornos virtuales e inmersión en los videojuegos
Authors: Cuenca Orozco David
Published: June 2019

El estudio de los mundos virtuales en los videojuegos, desde que se desprendió la dimensión técnica, han sido abordados por psicólogos, antropólogos y sociólogos. Para Galarneau, los jugadores se adscriben a estos mundos con la nalidad de colocar en su capacidad de agenciamiento y darse a conocer. Los estudios sobre la inmersión en el videojuego se abordan como "presencia" o "presencia", el sentido de este proceso se centra en el involucramiento amplio, consciente y total en un videojuego, que también se denomina "inmersión total", o " Presencia total ", esto no debe confundirse con el uso descontrolado de los videojuegos o el juego extremo, en tanto la inmersión es una experiencia, un proceso complejo para el grado de implicación en el juego del video. Este artículo presenta los estudios referentes a los entornos virtuales y la inmersión en los videojuegos.
Penerapan Aspek Kompetensi Administrasi, Transparansi Dan Efisiensi Dalam Restrukturisasi Birokrasi Pemerintah Daerah
Authors: Supriatna Dadang
Published: June 2019

Abstrack

 The implementation of the restructuring of the bureaucracy can be defined as a process of redesigning or rearrangement of the existing bureaucracy. When the dynamics on both internal and external environments that bureaucracy must also adapt these dynamics in order to survive. Adaptation to the dynamics of the causes of bureaucracy must perform in accordance with reality. Restructuring or realignment of bureaucratic organization is essentially an activity to prepare the unit will be assigned the bureaucratic organization of work areas, specific tasks or functions. Government Regulation No. 41 of 2007 is a government regulation governing guidelines for the preparation and control of the regional organization in the overall governance process.

Kata kunci: good governance, bureaucracy restructurization, local government
Peran Satuan Polisi Pamong Praja Dalam Penertiban Pedagang Kaki Lima Di Kota Semarang
Authors: Rukmana Maris Gunawan
Published: June 2019

Abstrak 

Satuan Polisi Pamong Praja merupakan lembaga yang berada di setiap Daerah Propinsi maupun kabupaten dan kota yang bertugas untuk menegakan peraturan daeran/ Perauran Keputusan Daerah, menyelenggarakan penertiban dan menyelenggarakan perlindungan masyarakat. Satuan Polisi Pamong Praja Kota Semarang dihadapkan dengan berbagai permasalahan ketertiban terutama Pedagang Kaki Lima ( PKL ). Kota Semarang sebagai Ibukota Provinsi Jawa Tengah antara lain  merupakan daerah yang menjadi tujuan hidup untuk merubah keadaan ekonomi masyarakat antara lain dengan berjualan menjadi PKL Dengan bertambahnya PKL maka beban tanggung jawab Satuan Polisi Pamong Praja semakin berat. Bagaimana peran Satpol Polisi Pamong Praja Kota Semarang dapat mengendalikan PKL dalam upaya menegakan ketertiban, kebersihan  dan Keindahan Kota melalui Peraturan Daerah Nomor 11 tahun 2000 tentang Pengaturan dan Pembinaan Pedagang Kaki Lima.

Kata kunci : Peran, Satpol PP, Ketertiban
The Role of Façade Materials in Blast-Resistant Buildings: An Evaluation Based on Fuzzy Delphi and Fuzzy EDAS
Authors: Hasheminasab Hamidreza , Hashemkhani Zolfani Sarfaraz , Bitarafan Mahdi , Chatterjee Prasenjit , Abhaji Ezabadi Alireza
Published: June 2019

Blast-resistant buildings are mainly used to protect main instruments, controllers, expensive equipment, and people from explosion waves. Oil and gas industry projects almost always include blast-resistant buildings. For instance, based on a hazard identification (HAZID) and hazard and operability (HAZOP) analysis of a plant, control rooms and substations are sometimes designed to withstand an external free air explosion that generates blast over pressure. In this regard, a building façade is considered to be the first barrier of resistance against explosion waves, and therefore a building façade has an important role in reducing a building’s vulnerability and human casualties. In case of a lack of enough resistance, explosion waves enter a building and bring about irreparable damage to the building. Consequently, it seems important to study and evaluate various materials used in a façade against the consequences of an explosion. This study tried to make a comparison between different types of building facades against explosion waves. The materials used in a building play a key role in the vulnerability of a building. In this research, a literature review and the fuzzy Delphi method were applied to find the most critical criteria, and then a fuzzy evaluation based on the distance from the average solution (EDAS) was applied in order to assess various materials used in building facades from the perspective of resiliency. A questionnaire was presented to measure effective indices in order to receive experts’ ideas. Finally, by implementing this methodology in a case study, it was concluded that a stone façade performs much better against explosions.
The Influence of Chemical, Organic and Biological Fertilizers on Agrobiological and Antioxidant Properties of Syrian Cephalaria (Cephalaria Syriaca L.)
Authors: Rahimi Amir , Siavash Moghaddam Sina , Ghiyasi Mahdi , Heydarzadeh Saeid , Ghazizadeh Kosar , Popović-Djordjević Jelena
Published: June 2019

Since chemical fertilizers pollute soil, water and crops, conscientious agricultural producers seek alternatives to chemical fertilizers. Biological fertilizers are considered a reliable alternative for improving soil productivity and plant growth in sustainable agriculture. The response of some agrobiological and antioxidant properties of Syrian cephalaria (Cephalaria syriaca L.) to different fertilizer sources was explored in an experiment which included: (i) mycorrhiza + manure; (ii) mycorrhiza + vermicompost; (iii) mycorrhiza + Azotobacter; (iv) mycorrhiza + chemical fertilizer; (v) mycorrhiza; and (vi) control. The results showed that the highest seed yield, biological yield, oil percentage yield, were observed in plants treated with mycorrhiza + vermicompost, whereas the highest 1000-seed weight was obtained from the application of mycorrhiza + manure. With respect to photosynthesizing pigments, the application of mycorrhiza + vermicompost increased chlorophyll a, chlorophyll b, total chlorophyll, carotenoid content as well as total phenols, total flavonoids and DPPH antioxidant activity as compared to control (unfertilized) plants. The mixed application of different fertilizer sources influenced the uptake of trace elements (Fe, Zn and Cu) optimally. In the light of the obtained results for the agrobiological and antioxidant properties of Syrian cephalaria, in most of the measured traits, there is no significant difference between manure, vermicompost and chemical fertilizers in combination with mycorrhiza. Hence the use of organic and biological inputs instead of chemical fertilizer for improving crop efficiency and quality with the aim of alleviating pollution and accomplishing sustainable agriculture is highly encouraging.
Gasotransmitters in Action: Nitric Oxide-Ethylene Crosstalk during Plant Growth and Abiotic Stress Responses
Authors: Kolbert Zsuzsanna , Feigl Gábor , Freschi Luciano , Poór Péter
Published: June 2019

Since their first description as atmospheric gases, it turned out that both nitric oxide (NO) and ethylene (ET) are multifunctional plant signals. ET and polyamines (PAs) use the same precursor for their synthesis, and NO can be produced from PA oxidation. Therefore, an indirect metabolic link between NO and ET synthesis can be considered. NO signal is perceived primarily through S-nitrosation without the involvement of a specific receptor, while ET signal is sensed by a well-characterized receptor complex. Both NO and ET are synthetized by plants at various developmental stages (e.g., seeds, fruits) and as a response to numerous environmental factors (e.g., heat, heavy metals) and they mutually regulate each other’s levels. Most of the growth and developmental processes (e.g., fruit ripening, de-etiolation) are regulated by NO–ET antagonism, while in abiotic stress responses, both antagonistic (e.g., dark-induced stomatal opening, cadmium-induced cell death) and synergistic (e.g., UV-B-induced stomatal closure, iron deficiency-induced expression of iron acquisition genes) NO–ET interplays have been revealed. Despite the numerous pieces of experimental evidence revealing NO–ET relationships in plants, the picture is far from complete. Understanding the mechanisms of NO–ET interactions may contribute to the increment of yield and intensification of stress tolerance of crop plants in changing environments.
Role of Cytosolic 2-Cys Prx1 and Prx2 in Redox Signaling
Authors: Kim Yosup , Jang Ho Hee
Published: June 2019

Peroxiredoxins (Prxs), a family of peroxidases, are reactive oxygen species scavengers that hydrolyze H2O2 through catalytic cysteine. Mammalian Prxs comprise six isoforms (typical 2-Cys Prxs; Prx1–4, atypical 2-Cys Prx; Prx5, and 1-Cys Prx; Prx6) that are distributed over various cellular compartments as they are classified according to the position and number of conserved cysteine. 2-Cys Prx1 and Prx2 are abundant proteins that are ubiquitously expressed mainly in the cytosol, and over 90% of their amino acid sequences are homologous. Prx1 and Prx2 protect cells from ROS-mediated oxidative stress through the elimination of H2O2 and regulate cellular signaling through redox-dependent mechanism. In addition, Prx1 and Prx2 are able to bind to a diversity of interaction partners to regulate other various cellular processes in cancer (i.e., regulation of the protein redox status, cell growth, apoptosis, and tumorigenesis). Thus, Prx1 and Prx2 can be potential therapeutic targets and it is particularly important to control their level or activity. This review focuses on cytosolic 2-Cys Prx1 and Prx2 and their role in the regulation of redox signaling based on protein-protein interaction.
Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review
Authors: Meng Jin-Ming , Cao Shi-Yu , Wei Xin-Lin , Gan Ren-You , Wang Yuan-Feng , Cai Shu-Xian , Xu Xiao-Yu , Zhang Pang-Zhen , Li Hua-Bin
Published: June 2019

Diabetes mellitus has become a serious and growing public health concern. It has high morbidity and mortality because of its complications, such as diabetic nephropathy, diabetic cardiovascular complication, diabetic neuropathy, diabetic retinopathy, and diabetic hepatopathy. Epidemiological studies revealed that the consumption of tea was inversely associated with the risk of diabetes mellitus and its complications. Experimental studies demonstrated that tea had protective effects against diabetes mellitus and its complications via several possible mechanisms, including enhancing insulin action, ameliorating insulin resistance, activating insulin signaling pathway, protecting islet β-cells, scavenging free radicals, and decreasing inflammation. Moreover, clinical trials also confirmed that tea intervention is effective in patients with diabetes mellitus and its complications. Therefore, in order to highlight the importance of tea in the prevention and management of diabetes mellitus and its complications, this article summarizes and discusses the effects of tea against diabetes mellitus and its complications based on the findings from epidemiological, experimental, and clinical studies, with the special attention paid to the mechanisms of action.
A Coordinated Dual-Channel Wide Area Damping Control Strategy for a Doubly-Fed Induction Generator Used for Suppressing Inter-Area Oscillation
Authors: Cai Guowei , Chen Xiangsong , Sun Zhenglong , Yang Deyou , Liu Cheng , Li Haobo
Published: June 2019

Using a doubly-fed induction generator (DFIG), with an additional active or reactive damping controller, is a new method of suppressing the inter-area oscillation of a power system. However, using active power modulation (APM) may decrease the damping of the shaft oscillation mode of a DFIG and the system damping target cannot be achieved through reactive power modulation (RPM) in some cases. Either single APM or RPM does not consider system damping and torsional damping simultaneously. In this paper, an active-reactive coordinated dual-channel power modulation (DCPM) damping controller is proposed for DFIGs. First, considering the electromechanical parts and control structure of the wind turbine, an electromechanical transient model and an additional damping controller model of DFIGs are established. Then, the dynamic objective function for coordinating the parameters of the additional damping controller is proposed. The ratio between the active power channel and reactive power channel modulation is derived from the parameters optimized by the particle swarm optimization algorithm. Finally, the effectiveness and practicability of the designed strategy is verified by comparing it with a traditional, simple damping controller design strategy. Standard simulation system examples are used in the comparison. Results show that the DCPM is better at maximizing the damping control capability of the rotor-side controller of a DFIG and simultaneously minimizing adverse effects on torsional damping than the traditional strategy.
Study of the Hygrothermal Behavior of Wood Fiber Insulation Subjected to Non-Isothermal Loading
Authors: Slimani Zakaria , Trabelsi Abdelkrim , Virgone Joseph , Zanetti Freire Roberto
Published: June 2019

Building envelopes are constantly subjected to temperature and moisture gradients. This loading induces a complex response, particularly for highly hygroscopic insulating materials. Latent effects can no longer be neglected for these materials in which heat and moisture transfers are strongly coupled. The purpose of this article is to analyze the behavior of a wood fiber insulation subjected to non-isothermal loading under a vapor concentration gradient. An experimental setup and a mathematical model of hygrothermal transfer were developed to analyze the behavior of the wall. The mathematical model describes the main physical phenomena involved, notably water vapor adsorption and the dependence of thermophysical properties in state variables. The experimental setup developed allows studying a wall under controlled conditions. The temperature and relative humidity profiles within the wall were measured. The evolution of the profiles with time suggests that the adsorption of the water vapor occurs together with the redistribution of liquid water within the envelope. The comparison of the experimental results with the numerical model shows good agreement although the prediction can be improved during the transient phase. The comparisons of these results with a purely diffusive thermal transfer model show the limits of the latter and permit quantifying the latent effects on the total heat transfer.
Effect of Cement Content on the Deformation Properties of Cemented Sand and Gravel Material
Authors: Yang Jie , Cai Xin , Guo Xing-Wen , Zhao Jin-Lei
Published: June 2019

Knowing the deformation properties of cemented sand and gravel (CSG) material can help construct reasonable constitutive models for the material, which can be used to simulate the structural performance of various practical projects including CSG dams. In this study, to investigate the effect of cement content on the deformation properties of CSG material, we employ triaxial compressive tests for cement contents of 20, 40, 60, 80, and 100 kg/m3 with a confining pressure range of 0.3–1.2 MPa, and theoretically analyze the results by the regression analysis prediction method. Here, we show that both cement content and confining pressure influence the deformation properties of CSG material: for an increase in cement content, the failure strain decreases and brittleness of CSG material increases; the initial modulus of the CSG material increased exponentially with increasing cement content or confining pressure; the peak volumetric strain and its corresponding axial strain increase linearly with increasing confining pressures, which decrease with increasing cement content; the initial tangent volumetric ratio can also be determined by the peak volumetric strain and its corresponding axial strain.
A Multidisciplinary Approach toward High Throughput Label-Free Cytotoxicity Monitoring of Superparamagnetic Iron Oxide Nanoparticles
Authors: Abad Tan Sonia , Zoidl Georg , Ghafar-Zadeh Ebrahim
Published: June 2019

This paper focuses on cytotoxicity examination of superparamagnetic iron oxide nanoparticles (SPIONs) using different methods, including impedance spectroscopy. Recent advances of SPIONs for clinical and research applications have triggered the need to understand their effects in cells. Despite the great advances in adapting various biological and chemical methods to assess in-vitro toxicity of SPIONs, less attention has been paid on the development of a high throughput label-free screening platform to study the interaction between the cells and nanoparticles including SPIONs. In this paper, we have taken the first step toward this goal by proposing a label-free impedimetric method for monitoring living cells treated with SPIONs. We demonstrate the effect of SPIONs on the adhesion, growth, proliferation, and viability of neuroblastoma 2A (N2a) cells using impedance spectroscopy as a label-free method, along with other standard microscopic and cell viability testing methods as control methods. Our results have shown a decreased viability of the cells as the concentration of SPIONs increases with percentages of 59%, 47%, and 40% for 100 µg/mL (C4), 200 µg/mL (C5), 300 µg/mL (C6), respectively. Although all SPIONs concentrations have allowed the growth of cells within 72 h, C4, C5, and C6 showed slower growth compared to the control (C1). The growth and proliferation of N2a cells are faster in the absence or low concentration of SPIONS. The percent coefficient of variation (% CV) was used to compare cell concentrations obtained by TBDE assay and a Scepter cell counter. Results also showed that the lower the SPIONs concentration, the lower the impedance is expected to be in the sensing electrodes without the cells. Meanwhile, the variation of surface area (∆S) was affected by the concentration of SPIONs. It was observed that the double layer capacitance was almost constant because of the higher attachment of cells, the lower surface area coated by SPIONs. In conclusion, impedance changes of electrodes exposed to the mixture of cells and SPIONs offer a wide dynamic range (>1 MΩ using Electric Cell-substrate Impedance electrodes) suitable for cytotoxicity studies. Based on impedance based, viability testing and microscopic methods’ results, SPIONs concentrations higher than 100 ug/mL and 300 ug/mL cause minor and major effects, respectively. We propose that a high throughput impedance-based label-free platform provides great advantages for studying SPIONs in a cell-based context, opening a window of opportunity to design and test the next generation of SPIONs with reduced toxicity for biomedical or medical applications.
Microbiological Properties of Microwave-Activated Carbons Impregnated with Enoxil and Nanoparticles of Ag and Se
Authors: Petuhov Oleg , Lupascu Tudor , Behunová Dominika , Povar Igor , Mitina Tatiana , Rusu Maria
Published: June 2019

Microwave-activated carbons from walnut shells (ACMW) were impregnated with Ag and Se nanoparticles and with the Enoxil biologically active preparation, and the microbiological properties of the obtained composites were studied. To increase the functionality of the adsorbent, the activated carbon was oxidized with ozone, resulting in ACMWO containing aliphatic and aromatic carboxylic groups. There was a considerable decrease in the specific surface of the activated carbon after the oxidation process. Nitrogen adsorption was used to determine the structural parameters of the activated carbons. A simultaneous thermal analysis was used to study the thermal behavior of intact and oxidized activated carbons. Infrared spectroscopy was applied to analyze the surface chemistry of the adsorbents. The microbiological activity of the activated carbons was studied using Escherichia coli bacteria and Candida albicans fungi. The kinetic study of the microbiological activity allowed the estimation of the bactericidal/fungicidal action time of the activated carbons.
An Efficient Energy-Aware Tasks Scheduling with Deadline-Constrained in Cloud Computing
Authors: BEN ALLA Said , BEN ALLA Hicham , TOUHAFI Abdellah , EZZATI Abdellah
Published: June 2019

Nowadays, Cloud Computing (CC) has emerged as a new paradigm for hosting and delivering services over the Internet. However, the wider deployment of Cloud and the rapid increase in the capacity, as well as the size of data centers, induces a tremendous rise in electricity consumption, escalating data center ownership costs and increasing carbon footprints. This expanding scale of data centers has made energy consumption an imperative issue. Besides, users’ requirements regarding execution time, deadline, QoS have become more sophisticated and demanding. These requirements often conflict with the objectives of cloud providers, especially in a high-stress environment in which the tasks have very critical deadlines. To address these issues, this paper proposes an efficient Energy-Aware Tasks Scheduling with Deadline-constrained in Cloud Computing (EATSD). The main goal of the proposed solution is to reduce the energy consumption of the cloud resources, consider different users’ priorities and optimize the makespan under the deadlines constraints. Further, the proposed algorithm has been simulated using the CloudSim simulator. The experimental results validate that the proposed approach can effectively achieve good performance by minimizing the makespan, reducing energy consumption and improving resource utilization while meeting deadline constraints.
Homisland-IO: Homogeneous Land Use/Land Cover over the Small Islands of the Indian Ocean
Authors: Révillion Christophe , Attoumane Artadji , Herbreteau Vincent
Published: June 2019

Many small islands are located in the southwestern Indian Ocean. These islands have their own environmental specificities and very fragmented landscapes. Generic land use products developed from low and medium resolution satellite images are not suitable for studying these small territories. This is why we have developed a land use/land cover product, called Homisland-IO, based on remote sensing processing on high spatial resolution satellite images acquired by SPOT 5 satellite between December 2012 and July 2014. This product has been produced using an object-based classification process. The overall accuracy of the product is 86%. Homisland-IO is freely accessible through a web portal and is thus available for future use.
CaosDB—Research Data Management for Complex, Changing, and Automated Research Workflows
Authors: Fitschen Timm , Schlemmer Alexander , Hornung Daniel , tom Wörden Henrik , Parlitz Ulrich , Luther Stefan
Published: June 2019

We present CaosDB, a Research Data Management System (RDMS) designed to ensure seamless integration of inhomogeneous data sources and repositories of legacy data in a FAIR way. Its primary purpose is the management of data from biomedical sciences, both from simulations and experiments during the complete research data lifecycle. An RDMS for this domain faces particular challenges: research data arise in huge amounts, from a wide variety of sources, and traverse a highly branched path of further processing. To be accepted by its users, an RDMS must be built around workflows of the scientists and practices and thus support changes in workflow and data structure. Nevertheless, it should encourage and support the development and observation of standards and furthermore facilitate the automation of data acquisition and processing with specialized software. The storage data model of an RDMS must reflect these complexities with appropriate semantics and ontologies while offering simple methods for finding, retrieving, and understanding relevant data. We show how CaosDB responds to these challenges and give an overview of its data model, the CaosDB Server and its easy-to-learn CaosDB Query Language. We briefly discuss the status of the implementation, how we currently use CaosDB, and how we plan to use and extend it.
Cross-Entropy Method for Content Placement and User Association in Cache-Enabled Coordinated Ultra-Dense Networks
Authors: Yu Jia , Wang Ye , Gu Shushi , Zhang Qinyu , Chen Siyun , Zhang Yalin
Published: June 2019

Due to the high splitting-gain of dense small cells, Ultra-Dense Network (UDN) is regarded as a promising networking technology to achieve high data rate and low latency in 5G mobile communications. In UDNs, each User Equipment (UE) may receive signals from multiple Base Stations (BSs), which impose severe interference in the networks and in turn motivates the possibility of using Coordinated Multi-Point (CoMP) transmissions to further enhance network capacity. In CoMP-based Ultra-Dense Networks, a great challenge is to tradeoff between the gain of network throughput and the worsening backhaul latency. Caching popular files on BSs has been identified as a promising method to reduce the backhaul traffic load. In this paper, we investigated content placement strategies and user association algorithms for the proactive caching ultra dense networks. The problem has been formulated to maximize network throughput of cell edge UEs under the consideration of backhaul load, which is a constrained non-convex combinatorial optimization problem. To decrease the complexity, the problem is decomposed into two suboptimal problems. We first solved the content placement algorithm based on the cross-entropy (CE) method to minimize the backhaul load of the network. Then, a user association algorithm based on the CE method was employed to pursue larger network throughput of cell edge UEs. Simulation were conducted to validate the performance of the proposed cross-entropy based schemes in terms of network throughput and backhaul load. The simulation results show that the proposed cross-entropy based content placement scheme significantly outperform the conventional random and Most Popular Content placement schemes, with with 50% and 20% backhaul load decrease respectively. Furthermore, the proposed cross-entropy based user association scheme can achieve 30% and 23% throughput gain, compared with the conventional N-best, No-CoMP, and Threshold based user association schemes.
Synchronous Reluctance Motor vs. Induction Motor at Low-Power Industrial Applications: Design and Comparison
Authors: Ozcelik Nezih Gokhan , Dogru Ugur Emre , Imeryuz Murat , Ergene Lale T.
Published: June 2019

Although three-phase induction motors are the most common motor type in industry, a growing interest has arisen in emerging electric motor technologies like synchronous reluctance motors and permanent magnet motors. Synchronous reluctance motors are a step forward compared to permanent magnet motors when the cost of the system is considered. The main focus of this study is low-power industrial applications, which generally use three-phase induction motors. In this study, the synchronous reluctance motor family is compared at three different power levels: 2.2 kW, 4 kW, and 5.5 kW. The aim of this study is to design and compare synchronous reluctance motors, which can be alternative to the reference induction motors. Finite element analysis is performed for the reference induction motors initially. Their stators are kept the same and the rotors are redesigned to satisfy output power requirements of the induction motors. Detailed design, analysis, and optimization processes are applied to the synchronous reluctance motors considering efficiency, power density, and manufacturing. The results are evaluated, and the optimized designs are chosen for each power level. They are prototyped and tested to measure their performance.
Study on a Simplified Structure of a Two-Stage Grid-Connected Photovoltaic System for Parameter Design Optimization
Authors: Xie Fan , Luo Zhenxiong , Qiu Dongyuan , Zhang Bo , Chen Yanfeng , Huang Liying
Published: June 2019

Conventional parameter designs of two-stage grid-connected photovoltaic (PV) system relied on its mathematical model of the cascade structure (CS), but the procedure is excessively cumbersome to implement. Besides, for a two-stage converter system, the coupling interaction between the power converters can directly lead to a poor parameter design. To overcome this drawback, this paper uses a simplified structure (SS) of single-phase two-stage grid-connected PV system to better design the parameters of the front-stage dc-dc converter. After establishing the small-signal model for SS and CS in the PV system, the relative eigenvalue sensitivity is used as the criterion for judging the influence of some parameters on the stability of the two structures. The stable boundary of MPPT control parameters is compared and discussed in SS and CS, respectively. In addition, the relationship between the front-stage dc-dc converter and the rear-stage dc-ac inverter is analyzed by the modal participation factor calculated in CS. An experiment is also performed at the end of this paper to further verify the feasibility of using SS to design the parameters of the dc-dc converter in the PV system.
Joint Point-Interval Prediction and Optimization of Wind Power Considering the Sequential Uncertainties of Stepwise Procedure
Authors: Hu Yang , Qiao Yilin , Chu Jingchun , Yuan Ling , Pan Lei
Published: June 2019

To support high-level wind energy utilization, wind power prediction has become a more and more attractive topic. To improve prediction accuracy and flexibility, joint point-interval prediction of wind power via a stepwise procedure is studied in this paper. Firstly, time-information-granularity (TIG) is defined for ultra-short-term wind speed prediction. Hidden features of wind speed in TIGs are extracted via principal component analysis (PCA) and classified via adaptive affinity propagation (ADAP) clustering. Then, Gaussian process regression (GPR) with joint point-interval estimation ability is adopted for stepwise prediction of the wind power, including wind speed prediction and wind turbine power curve (WTPC) modeling. Considering the sequential uncertainties of stepwise prediction, theoretical support for an uncertainty enlargement effect is deduced. Uncertainties’ transmission from single-step or receding multi-step wind speed prediction to wind power prediction is explained in detail. After that, normalized indexes for point-interval estimation performance are presented for GPR parameters’ optimization via a hybrid particle swarm optimization-differential evolution (PSO-DE) algorithm. K-fold cross validation (K-CV) is used to test the model stability. Moreover, due to the timeliness of data-driven GPR models, an evolutionary prediction mechanism via sliding time window is proposed to guarantee the required accuracy. Finally, measured data from a wind farm in northern China are acquired for validation. From the simulation results, several conclusions can be drawn: the multi-model structure has insignificant advantages for wind speed prediction via GPR; joint point-interval prediction of wind power is realizable and very reasonable; uncertainty enlargement exists for stepwise prediction of wind power while it is more significant after receding multi-step prediction of wind speed; a reasonable quantification mechanism for uncertainty is revealed and validated.
Exploiting Elastically Supported Masses in Cantilever for Resonance Frequencies Down-Shifted Vibration Energy Harvester
Authors: Wang Hai , Li Bin , Liu Yan , Zhang Min , Zhao Wei , Qin Hongbo
Published: June 2019

This paper presents a piezoelectric vibration energy harvester (PVEH) with resonance frequencies shifted down by elastically supported masses. The added elastic supporters can diminish the equivalent stiffness of the whole structure, leading to an evident decline in the resonance frequency of the cantilever body. Meantime, a new resonant peak is generated in the lower frequency range. The resonant frequency of the proposed PVEH can be easily adjusted by replacing the rubber band of the elastic support. The constructed configuration is theoretically investigated and experimentally verified. Compared with the conventional cantilever, the proposed device achieved a 46% decrease in resonance frequency and 87% enhancement in output power.
On the Use of Ultrafiltration or Microfiltration Polymeric Spiral-Wound Membranes for Cheesemilk Standardization: Impact on Process Efficiency
Authors: Chamberland Julien , Mercier-Bouchard Dany , Dussault-Chouinard Iris , Benoit Scott , Doyen Alain , Britten Michel , Pouliot Yves
Published: June 2019

Ultrafiltration (UF) and microfiltration (MF) are widely-used technologies to standardize the protein content of cheesemilk. Our previous work demonstrated that protein retention of a 0.1-µm MF spiral-wound membrane (SWM) was lower, but close to that of a 10 kDa UF one. Considering that the permeability of MF membranes is expected to be higher than that of UF ones, it was hypothesized that the former could improve the efficiency of the cheesemaking process. Consequently, the objectives of this work were to compare 0.1-µm MF and 10 kDa UF spiral-wound membranes in terms of (1) hydraulic and separation performance, (2) energy consumption and fouling behavior, (3) cheesemaking efficiency of retentates enriched with cream, and (4) economic performance in virtual cheesemaking plants. This study confirmed the benefits of using MF spiral-wound membranes to reduce the specific energy consumption of the filtration process (lower hydraulic resistance and higher membrane permeability) and to enhance the technological performance of the cheesemaking process (higher vat yield, and protein and fat recoveries). However, considering the higher serum protein retention of the UF membrane and the low price of electricity in Canada, the UF scenario remained more profitable. It only becomes more efficient to substitute the 10 kDa UF SWM by the 0.1-μm MF when energy costs are substantially higher.
Comparative Analysis of Lycopene Content from Different Tomato-Based Food Products on the Cellular Activity of Prostate Cancer Cell Lines
Authors: Soares Nathalia da Costa Pereira , Elias Monique de Barros , Machado Clara Lima , Trindade Bruno Boquimpani , Borojevic Radovan , Teodoro Anderson Junger
Published: June 2019

Lycopene is more bioavailable in processed tomato products than in raw tomatoes, since arrangement of cis-isomers of lycopene during food processing and storage may increase its biological activity. The aim of the study is evaluate the influence of lycopene content from different tomato-based food products (extract, paste, ketchup and sauce) on cell proliferation, cell cycle, and rate of apoptosis of human prostate cancer cell lines. DU-145 and PC-3 cell lines were treated with lycopene content from different tomato-based food products (500–5000 μg/mL) for 96 h. The data showed a decrease in cell viability in both DU-145 and PC-3 cells after treatment with all lycopene extracts from tomato-based food products. Analysis of cell cycle revealed a decrease in the percentage of prostate cancer cells in G0/G1 and G2/M phases after 96 h of treatment when using lycopene content from tomato paste and tomato extract. However, lycopene extracted from tomato sauce and ketchup promoted a decrease in the percentage of cells in G0/G1 phase and an increase in S and G2/M phases after 96 h of treatment. Lycopene content from all of those tomato-based food products also increased apoptosis in both prostate cancer cell lines. In this regard, lycopene has proved to be a potent inhibitor of cell viability, arrest cell cycle and increase the apoptosis in human prostate cancer cells, suggesting an effect in the balance of human prostate cancer cell lines growth.
Glacier Dynamics in Changme Khangpu Basin, Sikkim Himalaya, India, between 1975 and 2016
Authors: Debnath Manasi , Sharma Milap Chand , Syiemlieh Hiambok Jones
Published: June 2019

This study provides a high resolution glacier database in the Changme Khangpu Basin (CKB) using LANDSAT 8 (2014) and Sentinel-2A image (2016), mapping of 81 glaciers that cover a 75.78 ± 1.54 km2 area. Composite maps of land surface temperature, slope and Normalized differential Snow Index have been successfully utilized in delineating near accurate debris cover boundary of glaciers. The cumulative controlling parameters of aspect, elevation, slope, and debris cover have been assessed to evaluate the nature of glacier distribution and dynamics. The local topographic settings seem to have significantly determined the glacier distribution in the CKB. Almost 20% area erstwhile under glacier cover has been lost since 1975 at an average rate of −0.453 ± 0.001 km2a−1. The recent decade (2001–2016) has witnessed a higher rate of area shrinkage (−0.665 ± 0.243 km2a−1), compared to a relatively lower rate of recession (−0.170 ± 0.536 km2a−1) between 1988 and 2001. The lower rates of glacial recession can most likely be induced regionally due to relatively cooler decadal late summer temperatures and peak in the monsoon spell. Glaciers with western and north-western aspects showed more vulnerability to area loss than the rest of the aspects. Lower altitude glaciers have receded faster than ones perched up on higher elevations. The rate of glacier area recession has been nearly twice that on clean glaciers as compared to debris-covered glaciers in the CKB.
Multi-Period Network Design Problem in Regional Hazardous Waste Management Systems
Authors: Zhao Jun , Huang Lixiang
Published: June 2019

The management of hazardous wastes in regions is required to design a multi-echelon network with multiple facilities including recycling, treatment and disposal centers servicing the transportation, recycling, treatment and disposal procedures of hazardous wastes and waste residues. The multi-period network design problem within is to determine the location of waste facilities and allocation/transportation of wastes/residues in each period during the planning horizon, such that the total cost and total risk in the location and transportation procedures are minimized. With consideration of the life cycle capacity of disposal centers, we formulate the problem as a bi-objective mixed integer linear programming model in which a unified modeling strategy is designed to describe the closing of existing waste facilities and the opening of new waste facilities. By exploiting the characteristics of the proposed model, an augmented ε -constraint algorithm is developed to solve the model and find highly qualified representative non-dominated solutions. Finally, computational results of a realistic case demonstrate that our algorithm can identify obviously distinct and uniformly distributed representative non-dominated solutions within reasonable time, revealing the trade-off between the total cost and total risk objectives efficiently. Meanwhile, the multi-period network design optimization is superior to the single-period optimization in terms of the objective quality.