bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase Transitions of N-(4-methoxybenzylidene)-4-butylaniline (MBBA) Confined within Mesoporous Silica
Authors: Yoshimi Takehisa , Shima Ayumi , Hagiwara-Norifusa Shoko , Sugimoto Takayuki , Nagoe Atsushi , Fujimori Hiroki
Published: September 2020

We have used differential scanning calorimetry (DSC) to investigate the phase transition of a liquid crystal, N-(4-methoxybenzylidene)-4-butylaniline (MBBA), confined within porous silica materials with one- and three-dimensional pore architectures. Each phase-transition temperature of the confined MBBA linearly decreased with the inverse pore size compared with that of bulk MBBA. However, the degree of temperature shift varied owing to differences in the pore architectures. In addition, when MBBA was confined within one-dimensional pores, the thermal anomaly associated with the phase transition from the nematic phase to the isotropic liquid phase was not observed in the DSC measurements.
The Crystallization Behaviors of SiO2-Al2O3-CaO-MgO-TiO2 Glass-Ceramic Systems
Authors: Lai Feifei , Leng Mei , Li Jiangling , Liu Qingcai
Published: September 2020

To evaluate the crystallization behavior of Ti-bearing blast furnace slag-based glass ceramics, SiO2-Al2O3-CaO-MgO-TiO2 systems with various TiO2 were investigated. The crystallization process and mechanical properties were analyzed. The results show that with TiO2 increasing, exothermic peak temperature (Tp) decreases, and the crystallization is promoted by the introduction of TiO2. A small amount of TiO2 (≤4%) addition can significantly promote crystallization, and when TiO2 continues to increase, the crystallization is decreased slightly. The Avrami parameter (n) of all samples is less than 4, indicating that in prepared glass-ceramics, it is hard to achieve three-dimensional crystal growth. The main crystalline phase is akermanite–gehlenite. The addition of TiO2 has no obvious effect on the type of main crystalline phase. The prepared glass-ceramic with 4% TiO2 show good mechanical properties with the hardness values of 542.67 MPa. The recommended content of TiO2 is 4% for preparing glass-ceramics.
From Symptom Tracking to Contact Tracing: A Framework to Explore and Assess COVID-19 Apps
Authors: Ramakrishnan Abinaya Megan , Ramakrishnan Aparna Nicole , Lagan Sarah , Torous John
Published: September 2020

Smartphone applications related to coronavirus disease 2019 (COVID-19) continue to emerge and evolve, but despite a wide variety of different app functions, there has yet to be a comprehensive study of what the most prevalent publicly available apps provide, and there exists no standardized evaluation system for end users to determine the safety and efficacy of an app before they download it. Furthermore, limited oversight means that the rapidly growing space creates challenges for end users trying to find a relevant app. We adapted the M-Health Index and Navigation Database (MIND) from apps.digitalpsych.org that previously has been used to evaluate mental health applications to guide the assessment of COVID apps. Using this framework, we conducted a thorough analysis of the top-100 returned coronavirus apps on two separate dates a month apart to understand the clinical utility and features of COVID-19 apps and how these change in a short period of time. We ultimately identified a significant turnover rate, as well as privacy concerns around lack of privacy policies and disclosure of personal information. Our research offers insight into the current status of COVID-19 apps and provides a comprehensive and adaptable framework to help individuals assess the growing number of such digital tools in the wake of the pandemic.
Assessing Evolutionary Significant Units (ESU) of the Endangered Freshwater Pearl Mussel (Margaritifera margaritifera) in Southeast Norway on the Basis of Genetic Analysis
Authors: Linløkken Arne N. , Garlie Silje , Johansen Wenche , Wilson Robert C.
Published: September 2020

A total of 312 specimens of freshwater pearl mussel (Margaritifera margaritifera) were sampled from 11 populations, located in four different river systems in Southeast Norway, and analyzed for 11 simple sequence repeat (SSR) (microsatellite) markers. All study populations have landlocked brown trout (Salmo trutta) as the only possible host. Several populations had experienced recruitment failure, probably due to low pH (about 6.0) and calcium concentration. STRUCTURE clustering analysis revealed two genetic clusters, of which one cluster occurred mainly in the western river systems, and totally dominated in one population (Fallselva (A-FAL)) that had higher genetic diversity than the others. Cluster 2 completely dominated in the populations of the eastern river systems, and all of them had low genetic diversity. Bottleneck events were indicated in all populations and the inbreeding coefficient FIS was significant in all populations, except for the southernmost population (Sørkedalselva (B-SØR)), which was the only population with genotypes in Hardy–Weinberg equilibrium. FIS were especially high in the populations of the eastern river systems, and maximum shell length was negatively correlated to FIS. If artificially breeding and stocking should become necessary for future preservation, it should be based on single populations; alternatively, the eastern populations should be based on cross-breeding of populations within the cluster to increase their genetic diversity.
Trait Variation in Moths Mirrors Small-Scaled Ecological Gradients in A Tropical Forest Landscape
Authors: Rabl Dominik , Alonso-Rodríguez Aura M. , Brehm Gunnar , Fiedler Konrad
Published: September 2020

Along environmental gradients, communities are expected to be filtered from the regional species pool by physical constraints, resource availability, and biotic interactions. This should be reflected in species trait composition. Using data on species-rich moth assemblages sampled by light traps in a lowland rainforest landscape in Costa Rica, we show that moths in two unrelated clades (Erebidae-Arctiinae; Geometridae) are much smaller-sized in oil palm plantations than in nearby old-growth forest, with intermediate values at disturbed forest sites. In old-growth forest, Arctiinae predominantly show aposematic coloration as a means of anti-predator defense, whereas this trait is much reduced in the prevalence in plantations. Similarly, participation in Müllerian mimicry rings with Hymenoptera and Lycidae beetles, respectively, is rare in plantations. Across three topographic types of old-growth forests, community-weighted means of moth traits showed little variation, but in creek forest, both types of mimicry were surprisingly rare. Our results emphasize that despite their mobility, moth assemblages are strongly shaped by local environmental conditions through the interplay of bottom–up and top–down processes. Assemblages in oil palm plantations are highly degraded not only in their biodiversity, but also in terms of trait expression.
A Two-Year Follow-Up Cohort Study—Improved Clinical Control over CVD Risk Factors through Weight Loss in Middle-Aged and Older Adults
Authors: Macek Pawel , Terek-Derszniak Malgorzata , Biskup Malgorzata , Krol Halina , Smok-Kalwat Jolanta , Gozdz Stanislaw , Zak Marek
Published: September 2020

Modest weight loss enhances clinical control over cardiovascular disease (CVD) risk factors in overweight and obese individuals. This study aimed to assess the associations between individual weight loss and predefined criteria for clinical improvement in blood pressure, lipid levels, and glycemia. A two-year follow-up study involved 3388 (37.9% men) aged 45−64 years, BMI ≥ 25 kg/m2. Changes in body weight were calculated as a percentage of baseline weight; outcome variables: systolic (SBP), diastolic (DBP) blood pressure, high-density (HDL-C) and low-density (LDL-C) lipoproteins, fasting blood glucose (FBG), and triglycerides (TG) were construed as the differences between baseline and outcome values. Clinically significant improvement was defined as SBP/DBP reduction by 5 mm/Hg, FBG−20 mg/dL, LDL-C-10 mg/dL, TG−40 mg/dL, and HDL-C increase by 5 mg/dL. Apart from LDL-C, a modest 5%–10% weight loss was associated with clinically significantly improved outcomes. The incident rate ratios and 95% confidence intervals for clinical improvement of SBP were: 1.27 (1.14–1.40), DBP/1.30 (1.12–1.50), HDL/1.54 (1.18–2.02), and TG/1.69 (1.32–2.17). In the higher category of weight loss, associations were still manifest, although the results proved diagnostically challenging (low number of cases). Even though modest weight loss does enhance clinical control over CVD risk factors, offering regular medical guidance to patients is postulated to further boos the anticipated outcomes.
Key Strategies to Optimize Outcomes in Mild-to-Moderate Ulcerative Colitis
Authors: Solitano Virginia , D’Amico Ferdinando , Fiorino Gionata , Paridaens Kristine , Peyrin-Biroulet Laurent , Danese Silvio
Published: September 2020

Mesalamine (5-ASA) is the mainstay therapy in patients with mild-to-moderate active ulcerative colitis (UC). However, non-adherence to therapy and practice variability among gastroenterologists represent long-standing barriers, leading to poor outcomes. Additionally, targets to treat in UC are increasingly evolving from focusing on clinical remission to achieving endoscopic and histological healing. To date, systemic steroids are still recommended in non-responders to 5-ASA, despite their well-known side effects. Importantly, with the advent of new therapeutic options such as oral corticosteroids with topical activity (e.g., budesonide multimatrix system (MMX)), biologics, and small molecules, some issues need to be addressed for the optimal management of these patients in daily clinical practice. The specific positioning of these drugs in patients with mild-to-moderate disease remains unclear. This review aims to identify current challenges in clinical practice and to provide physicians with key strategies to optimize treatment of patients with mild-to-moderate UC, and ultimately achieve more ambitious therapeutic goals.
Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use
Authors: d’Abramo Cristina , D’Adamio Luciano , Giliberto Luca
Published: September 2020

Alzheimer’s disease (AD) is the most common type of dementia, affecting more than 5 million Americans, with steadily increasing mortality and incredible socio-economic burden. Not only have therapeutic efforts so far failed to reach significant efficacy, but the real pathogenesis of the disease is still obscure. The current theories are based on pathological findings of amyloid plaques and tau neurofibrillary tangles that accumulate in the brain parenchyma of affected patients. These findings have defined, together with the extensive neurodegeneration, the diagnostic criteria of the disease. The ability to detect changes in the levels of amyloid and tau in cerebrospinal fluid (CSF) first, and more recently in blood, has allowed us to use these biomarkers for the specific in-vivo diagnosis of AD in humans. Furthermore, other pathological elements of AD, such as the loss of neurons, inflammation and metabolic derangement, have translated to the definition of other CSF and blood biomarkers, which are not specific of the disease but, when combined with amyloid and tau, correlate with the progression from mild cognitive impairment to AD dementia, or identify patients who will develop AD pathology. In this review, we discuss the role of current and hypothetical biomarkers of Alzheimer’s disease, their specificity, and the caveats of current high-sensitivity platforms for their peripheral detection.
When Are Graded Rings Graded S-Noetherian Rings
Authors: Kim Dong Kyu , Lim Jung Wook
Published: September 2020

Let Γ be a commutative monoid, R=⨁α∈ΓRα a Γ-graded ring and S a multiplicative subset of R0. We define R to be a graded S-Noetherian ring if every homogeneous ideal of R is S-finite. In this paper, we characterize when the ring R is a graded S-Noetherian ring. As a special case, we also determine when the semigroup ring is a graded S-Noetherian ring. Finally, we give an example of a graded S-Noetherian ring which is not an S-Noetherian ring.
A Time Series Prediction Model of Foundation Pit Deformation Based on Empirical Wavelet Transform and NARX Network
Authors: Ma Qingwen , Liu Sihan , Fan Xinyu , Chai Chen , Wang Yangyang , Yang Ke
Published: September 2020

Large deep foundation pits are usually in a complex environment, so their surface deformation tends to show a stable rising trend with a small range of fluctuation, which brings certain difficulty to the prediction work. Therefore, in this study we proposed a nonlinear autoregressive exogenous (NARX) prediction method based on empirical wavelet transform (EWT) pretreatment is proposed for this feature. Firstly, EWT is used to conduct adaptive decomposition of the measured deformation data and extract the modal signal components with characteristic differences. Secondly, the main components affecting the deformation of the foundation pit are analyzed as a part of the external input. Then, we established a NARX prediction model for different components. Finally, all predicted values are superpositioned to obtain a total value, and the result is compared with the predicted results of the nonlinear autoregressive (NAR) model, empirical mode decomposition-nonlinear autoregressive (EMD-NAR) model, EWT-NAR model, NARX model, EMD-NARX model and EWT-NARX model. The results showed that, compared with the EWT-NAR and EWT-NARX models, the EWT-NARX model reduced the mean square error of KD25 by 91.35%, indicating that the feature of introducing external input makes NARX more suitable for combining with the EWT method. Meanwhile, compared with the EMD-NAR and EWT-NAR models, the introduction of the NARX model reduced the mean square error of KD25 by 78.58% and 95.71%, indicating that EWT had better modal decomposition capability than EMD.
Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations
Authors: Zhang Yi , Zhang Ting-jian , Tu Shun , Zhang Zhen-hao , Meng Fan-hao
Published: September 2020

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers. Therefore, Src has long been considered an attractive drug target in oncology. However, the development of Src inhibitors with selectivity and novelty has been challenging. In the present study, pharmacophore-based virtual screening and molecular docking were carried out to identify potential Src inhibitors. A total of 891 molecules were obtained after pharmacophore-based virtual screening, and 10 molecules with high docking scores and strong interactions were selected as potential active molecules for further study. Absorption, distribution, metabolism, elimination and toxicity (ADMET) property evaluation was used to ascertain the drug-like properties of the obtained molecules. The proposed inhibitor–protein complexes were further subjected to molecular dynamics (MD) simulations involving root-mean-square deviation and root-mean-square fluctuation to explore the binding mode stability inside active pockets. Finally, two molecules (ZINC3214460 and ZINC1380384) were obtained as potential lead compounds against Src kinase. All these analyses provide a reference for the further development of novel Src inhibitors.
A New Dinuclear Cobalt Complex for Copolymerization of CO2 and Propylene Oxide: High Activity and Selectivity
Authors: Wang Wen-Zhen , Zhang Kai-Yue , Jia Xin-Gang , Wang Li , Li Lei-Lei , Fan Wei , Xia Li
Published: September 2020

Based on the ligand H4Salen-8tBu (salen-4), a new dinuclear cobalt complex (salen-4)[Co(III)TFA]2 (salen-4 = 3,5-di-tert-butylsalicylaldehyde-3,3′-diaminobiphenylamine; TFA = trifluoroacetic acid) has been firstly synthesized and characterized. It shows high catalytic activity for the copolymerization of propylene oxide (PO) and carbon dioxide (CO2), yielding regioregular poly(propylene carbonate) (PPC) with little generation of propylene carbonate (PC) by-product. It has been found that (salen-4)[Co(III)TFA]2 shows higher activity at milder conditions, generating a polymer with maximum Mn of 293 kg/mol and a narrow molecular weight distribution PDI of 1.35. The influences of reaction time, CO2 pressure, reaction temperature, nature of the cocatalyst, catalyst dosage and substrate concentration on the molecular weight, yield and selectivity of the polymer were explored in detail. The results showed that the (salen-4)[Co(III)TFA]2/[PPN]TFA catalyst system demonstrated a remarkable TOF as high as 735 h–1. In addition, a hypothetical catalytic reaction mechanism was proposed based on density functional theory (DFT) calculations and the catalytic reaction results of the (salen-4)[Co(III)TFA]2.
Tackling Resistance to Cancer Immunotherapy: What Do We Know?
Authors: Gondhowiardjo Soehartati A. , Handoko  , Jayalie Vito Filbert , Apriantoni Riyan , Barata Andreas Ronald , Senoaji Fajar , Utami IGAA Jayanthi Wulan , Maubere Ferdinand , Nuryadi Endang , Giselvania Angela
Published: September 2020

Cancer treatment has evolved tremendously in the last few decades. Immunotherapy has been considered to be the forth pillar in cancer treatment in addition to conventional surgery, radiotherapy, and chemotherapy. Though immunotherapy has resulted in impressive response, it is generally limited to a small subset of patients. Understanding the mechanisms of resistance toward cancer immunotherapy may shed new light to counter that resistance. In this review, we highlighted and summarized two major hurdles (recognition and attack) of cancer elimination by the immune system. The mechanisms of failure of some available immunotherapy strategies were also described. Moreover, the significance role of immune compartment for various established cancer treatments were also elucidated in this review. Then, the mechanisms of combinatorial treatment of various conventional cancer treatment with immunotherapy were discussed. Finally, a strategy to improve immune cancer killing by characterizing cancer immune landscape, then devising treatment based on that cancer immune landscape was put forward.
Salumycin, a New Pyrazolequinone from a Streptomyces albus J1074 Mutant Strain
Authors: Tao Kaixiang , Ye Taijia , Cao Mingming , Meng Xiaolu , Li Yuqing , Wang Huan , Feng Zhiyang
Published: September 2020

Heterocyclic natural products with various bioactivities play significant roles in pharmaceuticals. Here, we isolated a heterocyclic compound salumycin (1) from a Streptomyces albus J1074 mutant strain. The structure of (1) was elucidated via single-crystal X-ray diffraction, mass spectrometry (MS), fourier transform infrared spectrometer (FTIR), and nuclear magnetic resonance (NMR) data analysis. Salumycin (1) contained a novel pyrazolequinone ring, which had never been previously reported in a natural product. Salumycin (1) exhibited moderate 2,2′-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging activity (EC50 = 46.3 ± 2.2 μM) compared with tert-butylhydroquinone (EC50 = 4.7 ± 0.3 μM). This study provides a new example of discovering novel natural products from bacteria.
A Quantitative Phytochemical Comparison of Olive Leaf Extracts on the Australian Market
Authors: Breakspear Ian , Guillaume Claudia
Published: September 2020

Olive leaf extract (OLE), prepared from the fresh or dried leaves of Olea europaea L., is generating interest as a cardiovascular and metabolic disease risk modifier. Positive effects for the leaf extract and its key phytochemical constituents have been reported on blood pressure, respiratory infections, inflammation, and insulin resistance. A variety of OLE products are available both over-the-counter and for professional dispensing. The aim of this research was to quantitatively explore the phytochemical profile of different OLE products on the Australian market. Ten OLE products available on the Australian market (five over-the-counter products and five products for professional compounding and dispensing) were quantitatively analyzed for oleuropein, hydroxytyrosol, oleacein, oleocanthal, total biophenols, maslinic acid, and oleanolic acid, using high-performance liquid chromatography (HPLC). Substantial variation in oleuropein and hydroxytyrosol levels was noted between extracts, with a trend towards higher oleuropein and lower hydroxytyrosol levels being noted in products produced using the fresh olive leaf as opposed to dry olive leaf. These results suggest that OLE products on the Australian market vary substantially in their phytochemical profiles. Products for professional compounding and dispensing in many cases contained less oleuropein than over-the-counter products, but more hydroxytyrosol and comparable total biophenol levels.
Molecular Engineering Enhances the Charge Carriers Transport in Wide Band-Gap Polymer Donors Based Polymer Solar Cells
Authors: Liu Siyang , Yi Shuwang , Qing Peiling , Li Weijun , Gu Bin , He Zhicai , Zhang Bin
Published: September 2020

The novel and appropriate molecular design for polymer donors are playing an important role in realizing high-efficiency and high stable polymer solar cells (PSCs). In this work, four conjugated polymers (PIDT-O, PIDTT-O, PIDT-S and PIDTT-S) with indacenodithiophene (IDT) and indacenodithieno [3,2-b]thiophene (IDTT) as the donor units, and alkoxy-substituted benzoxadiazole and benzothiadiazole derivatives as the acceptor units have been designed and synthesized. Taking advantages of the molecular engineering on polymer backbones, these four polymers showed differently photophysical and photovoltaic properties. They exhibited wide optical bandgaps of 1.88, 1.87, 1.89 and 1.91 eV and quite impressive hole mobilities of 6.01 × 10−4, 7.72 × 10−4, 1.83 × 10−3, and 1.29 × 10−3 cm2 V−1 s−1 for PIDT-O, PIDTT-O, PIDT-S and PIDTT-S, respectively. Through the photovoltaic test via using PIDT-O, PIDTT-O, PIDT-S and PIDTT-S as donor materials and [6,6]-phenyl-C-71-butyric acid methyl ester (PC71BM) as acceptor materials, all the PSCs presented the high open circuit voltages (Vocs) over 0.85 V, whereas the PIDT-S and PIDTT-S based devices showed higher power conversion efficiencies (PCEs) of 5.09% and 4.43%, respectively. Interestingly, the solvent vapor annealing (SVA) treatment on active layers could improve the fill factors (FFs) extensively for these four polymers. For PIDT-S and PIDTT-S, the SVA process improved the FFs exceeding 71%, and ultimately the PCEs were increased to 6.05%, and 6.12%, respectively. Therefore, this kind of wide band-gap polymers are potentially candidates as efficient electron-donating materials for constructing high-performance PSCs.
Design of Dual-Band Terahertz Perfect Metamaterial Absorber Based on Circuit Theory
Authors: Liu Zhongmin , Guo Liang , Zhang Qingmao
Published: September 2020

We present a novel strategy for designing a dual-band absorber based on graphene metasurface for terahertz frequencies. The absorber consists of a two-dimensional array of patches deposited on a metal-backed dielectric layer. Using an analytical circuit model, we obtain closed-form relatinos for the geometrical parameters of the absorber and the properties of the applied materials to achieve the dual-band absorber. Two absorption bands with perfect absorption at the preset frequencies of 0.5 and 1.5 THz are achieved. The results obtained by the analytical circuit model are compared to the simulations carried out by full-wave electromagnetic field analysis. The agreement between results is very good. We demonstrate that the graphene absorber remains as the dual band for a wide range of the chemical potential. Furthermore, the recommended dual band absorber is insensitive in terms of polarization and remain within various incident angles.
Wine’s Phenolic Compounds and Health: A Pythagorean View
Authors: Visioli Francesco , Panaite Stefan-Alexandru , Tomé-Carneiro Joao
Published: September 2020

In support of the J curve that describes the association between wine consumption and all-cause mortality, researchers and the lay press often advocate the health benefits of (poly)phenol consumption via red wine intake and cite the vast amount of in vitro literature that would corroborate the hypothesis. Other researchers dismiss such evidence and call for total abstention. In this review, we take a skeptical, Pythagorean stance and we critically try to move the debate forward by pointing the readers to the many pitfalls of red wine (poly)phenol research, which we arbitrarily treat as if they were pharmacological agents. We conclude that, after 30 years of dedicated research and despite the considerable expenditure, we still lack solid, “pharmacological”, human evidence to confirm wine (poly)phenols’ biological actions. Future research will eventually clarify their activities and will back the current recommendations of responsibly drinking moderate amounts of wine with meals.
Electrochemical Degradation of Industrial Dyes in Wastewater through the Dissolution of Aluminum Sacrificial Anode of Cu/Al Macro-Corrosion Galvanic Cell
Authors: Łuba Mateusz , Mikołajczyk Tomasz , Pierożyński Bogusław , Smoczyński Lech , Wojtacha Paweł , Kuczyński Mateusz
Published: September 2020

This paper reports on the process of industrial-type wastewater purification carried-out through continuous anodic dissolution of aluminum alloy sacrificial anode for artificially aerated Cu-Al alloy galvanic (macro-corrosion) cells and synthetically prepared wastewater solutions. Electrochemical experiments were performed by means of a laboratory size electrolyzer unit, where the electrocoagulation process along with surface-induced electrooxidation phenomena were examined for wastewater containing Acid Mixture and Disperse Red 167 dyes. Final reduction of the dyes concentrations came to 32 and 99% for Acid Mixture and Disperse Red 167, correspondingly. The above was visualized through the employment of electrochemical (cyclic voltammetry and a.c. impedance spectroscopy techniques) and instrumental spectroscopy analyses.
Sono-Assembly of the [Arg-Phe]4 Octapeptide into Biofunctional Nanoparticles
Authors: Baral Anshul , Bhangu Sukhvir K. , Cimino Rita , Pelin Juliane N. B. D. , Alves Wendel A. , Chattopadhyay Santanu , Ashokkumar Muthupandian , Cavalieri Francesca
Published: September 2020

High-frequency ultrasound treatment is found to be a one-pot green technique to produce peptide-based nanostructures by ultrasound assisted self-assembly of oligopeptides. [Arg-Phe]4 octapeptides, consisting of alternating arginine (Arg/R) and phenylalanine (Phe/F) sequences, were subjected to 430 kHz ultrasound in aqueous solution in the absence of any external agents, to form [RF]4 nanoparticles ([RF]4-NPs), ~220 nm in diameter. A comprehensive analysis of the obtained nanoparticles demonstrated that the aromatic moieties of the oligopeptides can undergo oxidative coupling to form multiple oligomeric species, which then self-assemble into well-defined fluorescent nanoparticles. [RF]4-NPs were functionalized with polyethylene glycol (PEGylated) to improve their colloidal stability. Unlike the parent peptide, the PEGylated [RF]4-NPs showed limited cytotoxicity towards MDA-MB-231 cells. Furthermore, the intracellular trafficking of PEGylated [RF]4-NPs was investigated after incubation with MDA-MB-231 cells to demonstrate their efficient endo-lysosomal escape. This work highlights that the combined use of ultrasonic technologies and peptides enables easy fabrication of nanoparticles, with potential application in drug delivery.
A Facile and Controllable Vapor-Phase Hydrothermal Approach to Anionic S2−-doped TiO2 Nanorod Arrays with Enhanced Photoelectrochemical and Photocatalytic Activity
Authors: Yu Hai , Zhang Miao , Wang Yanfen , Yang Haocheng , Liu Yanmei , Yang Lei , He Gang , Sun Zhaoqi
Published: September 2020

Anionic S2−-doped TiO2 nanorod arrays (S2−-TiO2) were synthesized by a facile and controllable vapor-phase hydrothermal (VPH) approach based on the sulfur source of H2S gas. After the VPH treatment of TiO2 nanorod arrays (TNA), the isolated O2− species replaces the S2− ion in TiO2 (TiO2−xSx). The structural, morphological, optical, compositional, photocatalytic and photoelectrochemical (PEC) properties of the obtained samples were investigated in detail. It was found that S2−-TiO2 can enhance the separation rate of electron–hole pairs, improve the absorption of visible light, and augment the photocatalytic and photoelectrochemical properties. Anionic S2− doping can significantly adjust the absorption cut-off wavelength (409.5–542.5 nm) and shorten the bandgap (3.05-2.29 eV) of TNA. For the degradation of methylene orange (MO) under mercury lamp light, the 0.24 At%S2−-TiO2 (0.24S2−-TiO2) sample exhibited the best photogradation efficiency of 73% in 180 min compared to bare TiO2 (46%). The 0.24S2−-TiO2 showed the highest photocurrent of 10.6 μA/cm2, which was 1.73 times higher than that of bare TiO2 (6.1μA/cm2). The results confirmed that the visible light absorption, photocurrent and photocatalytic activity optimization of TNA are closely related not only to anionic S2−-doped but also different ratios of anionic S2−-doped. It is noteworthy that the VPH approach is very promising for applications in low cost and highly efficient ion doping into nanomaterials for energy devices.
Correction: Yao, C.A., et al. Soy-Based Multiple Amino Acid Oral Supplementation Increases the Anti-Sarcoma Effect of Cyclophosphamide. Nutrients 2016, 8, 192
Authors: Yao Chien-An , Chen Chin-Chu , Wang Nai-Phog , Chien Chiang-Ting
Published: September 2020

The authors wish to make the following correction to their published paper [...]
Mayaro Virus Pathogenesis and Transmission Mechanisms
Authors: Diagne Cheikh Tidiane , Bengue Michèle , Choumet Valérie , Hamel Rodolphe , Pompon Julien , Missé Dorothée
Published: September 2020

Mayaro virus (MAYV), isolated for the first time in Trinidad and Tobago, has captured the attention of public health authorities worldwide following recent outbreaks in the Americas. It has a propensity to be exported outside its original geographical range, because of the vast distribution of its vectors. Moreover, most of the world population is immunologically naïve with respect to infection with MAYV which makes this virus a true threat. The recent invasion of several countries by Aedesalbopictus underscores the risk of potential urban transmission of MAYV in both tropical and temperate regions. In humans, the clinical manifestations of MAYV disease range from mild fever, rash, and joint pain to arthralgia. In the absence of a licensed vaccine and clinically proven therapeutics against Mayaro fever, prevention focuses mainly on household mosquito control. However, as demonstrated for other arboviruses, mosquito control is rather inefficient for outbreak management and alternative approaches to contain the spread of MAYV are therefore necessary. Despite its strong epidemic potential, little is currently known about MAYV. This review addresses various aspects of MAYV, including its epidemiology, vector biology, mode of transmission, and clinical complications, as well as the latest developments in MAYV diagnosis.
The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections
Authors: Panossian Alexander , Brendler Thomas
Published: September 2020

The aim of our review is to demonstrate the potential of herbal preparations, specifically adaptogens for prevention and treatment of respiratory infections, as well as convalescence, specifically through supporting a challenged immune system, increasing resistance to viral infection, inhibiting severe inflammatory progression, and driving effective recovery. The evidence from pre-clinical and clinical studies with Andrographis paniculata, Eleutherococcus senticosus, Glycyrrhiza spp., Panax spp., Rhodiola rosea, Schisandra chinensis, Withania somnifera, their combination products and melatonin suggests that adaptogens can be useful in prophylaxis and treatment of viral infections at all stages of progression of inflammation as well as in aiding recovery of the organism by (i) modulating innate and adaptive immunity, (ii) anti-inflammatory activity, (iii) detoxification and repair of oxidative stress-induced damage in compromised cells, (iv) direct antiviral effects of inhibiting viral docking or replication, and (v) improving quality of life during convalescence.
Single-Walled Carbon Nanohorns as Promising Nanotube-Derived Delivery Systems to Treat Cancer
Authors: Moreno-Lanceta Alazne , Medrano-Bosch Mireia , Melgar-Lesmes Pedro
Published: September 2020

Cancer has become one of the most prevalent diseases worldwide, with increasing incidence in recent years. Current pharmacological strategies are not tissue-specific therapies, which hampers their efficacy and results in toxicity in healthy organs. Carbon-based nanomaterials have emerged as promising nanoplatforms for the development of targeted delivery systems to treat diseased cells. Single-walled carbon nanohorns (SWCNH) are graphene-based horn-shaped nanostructure aggregates with a multitude of versatile features to be considered as suitable nanosystems for targeted drug delivery. They can be easily synthetized and functionalized to acquire the desired physicochemical characteristics, and no toxicological effects have been reported in vivo followed by their administration. This review focuses on the use of SWCNH as drug delivery systems for cancer therapy. Their main applications include their capacity to act as anticancer agents, their use as drug delivery systems for chemotherapeutics, photothermal and photodynamic therapy, gene therapy, and immunosensing. The structure, synthesis, and covalent and non-covalent functionalization of these nanoparticles is also discussed. Although SWCNH are in early preclinical research yet, these nanotube-derived nanostructures demonstrate an interesting versatility pointing them out as promising forthcoming drug delivery systems to target and treat cancer cells.
Highly Active Carbon-Based Electrocatalysts for Dye-Sensitized Solar Cells: A Brief Review
Authors: Tseng Chi-Ang , Lee Chuan-Pei
Published: September 2020

Dye-sensitized solar cells (DSSCs) have emerged as promising alternatives to traditional silicon-based solar cells due to their relatively high conversion efficiency, low cost, flexibility, and environmentally benign fabrication processes. In DSSCs, platinum (Pt)-based materials used as the counter electrode (CE) exhibit the superior catalytic ability toward the reduction reaction of triiodide ions, which are attributed to their excellent catalytic activity and high electrical conductivity. However, Pt-based materials with high cost and limited supply hinder them from mass production. Developing highly active and stable CE materials without noble metals has been a persistent challenge for the practical application in DSSCs. Recently, a number of earth-abundant catalysts, especially carbon-based materials, display high activity, low cost, and good stability that render them attractive candidates to replace Pt in DSSCs. Herein, we will briefly review recent progress on carbon-based electrocatalysts as CEs in DSSC applications. The strategies of improving the catalytic activity of carbon-based materials such as structural engineering and/or heteroatom doping will be introduced. The active sites toward the reduction reaction of triiodide ions summarized from experimental results or theoretical calculation will also be discussed. Finally, the futuristic prospects and challenges of carbon-based electrocatalysts as CEs in DSSCs will be briefly mentioned.
Aerobic Barley Mg-protoporphyrin IX Monomethyl Ester Cyclase is Powered by Electrons from Ferredoxin
Authors: Stuart David , Sandström Malin , Youssef Helmy M. , Zakhrabekova Shakhira , Jensen Poul Erik , Bollivar David W. , Hansson Mats
Published: September 2020

Chlorophyll is the light-harvesting molecule central to the process of photosynthesis. Chlorophyll is synthesized through 15 enzymatic steps. Most of the reactions have been characterized using recombinant proteins. One exception is the formation of the isocyclic E-ring characteristic of chlorophylls. This reaction is catalyzed by the Mg-protoporphyrin IX monomethyl ester cyclase encoded by Xantha-l in barley (Hordeum vulgare L.). The Xantha-l gene product (XanL) is a membrane-bound diiron monooxygenase, which requires additional soluble and membrane-bound components for its activity. XanL has so far been impossible to produce as an active recombinant protein for in vitro assays, which is required for deeper biochemical and structural analyses. In the present work, we performed cyclase assays with soluble and membrane-bound fractions of barley etioplasts. Addition of antibodies raised against ferredoxin or ferredoxin-NADPH oxidoreductase (FNR) inhibited assays, strongly suggesting that reducing electrons for the cyclase reaction involves ferredoxin and FNR. We further developed a completely recombinant cyclase assay. Expression of active XanL required co-expression with an additional protein, Ycf54. In vitro cyclase activity was obtained with recombinant XanL in combination with ferredoxin and FNR. Our experiment demonstrates that the cyclase is a ferredoxin-dependent enzyme. Ferredoxin is part of the photosynthetic electron-transport chain, which suggests that the cyclase reaction might be connected to photosynthesis under light conditions.
The Roles of Cytokinins in Plants and Their Response to Environmental Stimuli
Authors: Emery R. J. Neil , Kisiala Anna
Published: September 2020

Cytokinins (CKs) are adenine-derived, small-molecule plant growth regulators that control aspects of almost all plant growth and development processes. Internally, CKs play significant roles in plant cell division, nutrient allocation, and photosynthetic performance, and they are also detection and signaling agents for plant responses to the environmental challenges. CK functions in plant metabolism include plant adaptations to various abiotic stresses as well as their regulatory role in plant interactions with biotic components of the environment. Interestingly, CK biosynthesis is not exclusive to plants. New genetic and chemical approaches have revealed that both beneficial (symbiotic microorganisms) and detrimental (pathogenic bacteria, fungi, or insects) non-plant biota can secrete these phytohormones to purposefully modify plant metabolism. Therefore, while many open questions remain about how CKs are actively utilized by plants and plant-interacting organisms, CK roles should be seen more broadly, as signaling molecules for which effects range from within cells to as far as interkingdom relationships. The papers in this Special Issue highlight several aspects of CK biosynthesis, metabolism, and functions within plants and among plant-associated organisms, typifying the extensive range of roles played by these signaling molecules. The collection of papers represents new examples for CK researchers to consider advancing the growing range of topics related to how CKs mediate responses to many kinds of environmental stimuli and stresses.
Effect of Active Site Modification towards Performance Enhancement in Biopolymer κ-Carrageenan Derivatives
Authors: Abu Bakar Mohd Hafiz , Azeman Nur Hidayah , Mobarak Nadhratun Naiim , Mokhtar Mohd Hadri Hafiz , A Bakar Ahmad Ashrif
Published: September 2020

This research demonstrates a one-step modification process of biopolymer carrageenan active sites through functional group substitution in κ-carrageenan structures. The modification process improves the electronegative properties of κ-carrageenan derivatives, leading to enhancement of the material’s performance. Synthesized succinyl κ-carrageenan with a high degree of substitution provides more active sites for interaction with analytes. The FTIR analysis of succinyl κ-carrageenan showed the presence of new peaks at 1068 cm−1, 1218 cm−1, and 1626 cm−1 that corresponded to the vibrations of C–O and C=O from the carbonyl group. A new peak at 2.86 ppm in 1H NMR represented the methyl proton neighboring with C=O. The appearance of new peaks at 177.05 and 177.15 ppm in 13C NMR proves the substitution of the succinyl group in the κ-carrageenan structure. The elemental analysis was carried out to calculate the degree of substitution with the highest value of 1.78 at 24 h of reaction. The XRD diffractogram of derivatives exhibited a higher degree of crystallinity compared to pristine κ-carrageenan at 23.8% and 9.2%, respectively. Modification of κ-carrageenan with a succinyl group improved its interaction with ions and the conductivity of the salt solution compared to its pristine form. This work has a high potential to be applied in various applications such as sensors, drug delivery, and polymer electrolytes.
The Efficiency of UV Picosecond Laser Processing in the Shaping of Surface Structures on Elastomers
Authors: Antoszewski Bogdan , Tofil Szymon , Mulczyk Krystian
Published: September 2020

Elastomers are used as construction materials in numerous industries, and in particular the biomedical industry, mechatronics, electronics, the automotive industry, and chemical devices. The paper presents the results of tests involving the effects of microprocessing of elastomeric materials using a UV laser emitting picosecond pulses. In particular, it presents an analysis of the influence of the parameters of processing on its efficiency. The paper provides a recommendation of the most advantageous processing parameters for materials such as polyurethane and silicone (MVQ). The authors see prospects for the use of the developed technology in the techniques of sealing and microfluidisation. The final part of the paper presents examples of surface structures generated on elements made of artificial materials and the results of tests involving reduction of friction resistance of sealing rings in a pneumatic actuator.
A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications
Authors: Khalil H. P. S. Abdul , Jummaat Fauziah , Yahya Esam Bashir , Olaiya N. G. , Adnan A. S. , Abdat Munifah , N. A. M. Nasir , Halim Ahmad Sukari , Kumar U. Seeta Uthaya , Bairwan Rahul , Suriani A. B.
Published: September 2020

Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.
Study of the Influence of the Almond Shell Variety on the Mechanical Properties of Starch-Based Polymer Biocomposites
Authors: Ibáñez García Ana , Martínez García Asunción , Ferrándiz Bou Santiago
Published: September 2020

This article is focused on the development of a series of biodegradable and eco-friendly biocomposites based on starch polymer (Mater-Bi DI01A) filled with 30 wt% almond shell (AS) of different varieties (Desmayo Rojo, Largueta, Marcona, Mollar, and a commercial mixture of varieties) to study the influence of almond variety in the properties of injected biodegradable parts. The different AS varieties are analysed by means of Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), Scanning Electron Microscopy (SEM), and X-ray Diffraction (XRD). The biocomposites are prepared in a twin-screw extruder and characterized in terms of their mechanical (tensile, flexural, Charpy impact, and hardness tests) and thermal properties (differential scanning calorimetry (DSC) and TGA). Despite observing differences in the chemical composition of the individual varieties with respect to the commercial mixture, the results obtained from the mechanical characterisation of the biocomposites do not present significant differences between the diverse varieties used. From these results, it was concluded that the most recommended option is to work with the commercial mixture of almond shell varieties, as it is easier and cheaper to acquire.
Mitigation of Chromium Poisoning of Ferritic Interconnect from Annealed Spinel of CuFe2O4
Authors: Hassan Muhammad Aqib , Mamat Othman Bin
Published: September 2020

Low-temperature solid oxide fuel cells permit the possibility of metallic interconnects over conventional ceramic interconnects. Among various metallic interconnects, the ferritic interconnects are the most promising. However, chromium poisoning in them adversely affects their performance. To resolve this issue, various coatings and pretreatment methods have been studied. Herein, this article encloses the coating of CuFe2O4 spinel over two prominent ferritic interconnects (Crofer 22 APU and SUS 430). The CuFe2O4 spinel layer coating has been developed by the dip-coating of both samples in CuFe2O4 slurry, followed by heat treatment at 800 °C in a reducing environment (5% hydrogen and 95% nitrogen). Additionally, both samples were annealed to further enhance their spinel coating structure. The morphological and crystallinity analysis confirmed that the spinel coating formed multiple layers of protection while annealing further reduced the thickness and improved the densities. Moreover, the area-specific resistance (ASR) and weight gain rate (WGR) of both samples before and after annealing was calculated using mathematical modeling, which matches with the experimental data. It has been noted that CuFe2O4 spinel coating improved the ASR and WGR of both samples which were further improved after annealing. This research reveals that the CuFe2O4 spinel is the promising protective layer for ferritic interconnects and annealing is the better processing technique for achieving the preferred properties.
Model Predictive Control for First-Order Hyperbolic System Based on Quasi-Shannon Wavelet Basis
Authors: Ai Ling , Teo Kok Lay , Deng Liwei , Zhang Desheng
Published: September 2020

In this paper, we consider a class of first-order hyperbolic distributed parameter systems. Our focus is on the design of a new class of model predictive control schemes using a quasi-Shannon wavelet basis. First, the first-order hyperbolic distributed parameter system is transformed into an equivalent system using collocation techniques for the approximation of spatial derivatives and Euler forward difference method for the approximation of the time component. Then, a model reduction method is applied to obtain a reduced-order system on which a nonlinear model predictive controller is designed through solving a nonlinear quadratic programming problem with input constraints. For illustration, the temperature control of a flow-control long-duct heating system is considered to be an example. A comparative simulation study is conducted to demonstrate the effectiveness of the proposed method.