bluuebunny/crossref_metadata_2025 huggingface dataset:
Extracting h-Backbone as a Core Structure in Weighted Networks
Authors: Zhang Ronda J. , Stanley H. Eugene , Ye Fred Y.
Published: September 2018

Determining the core structure of complex network systems allows us to simplify them. Using h-bridge and h-strength measurements in a weighted network, we extract the h-backbone core structure. We find that focusing on the h-backbone in a network allows greater simplification because it has fewer edges and thus fewer adjacent nodes. We examine three practical applications: the co-citation network in an information system, the open flight network in a social system, and coauthorship in network science publications.
Simple method for fabricating scattering layer using random nanoscale rods for improving optical properties of organic light-emitting diodes
Authors: Kwack Jin Ho , Choi Junhee , Park Cheol Hwee , Hwang Ha , Park Young Wook , Ju Byeong-Kwon
Published: September 2018

We investigated a low-temperature mask-free process for preparing random nanoscale rods (RNRs) as a scattering layer. The process involves spin coating and dry etching, which are already widely applied in industry. Our film exhibited 17–33% optical haze at 520 nm wavelength and 95% total transmittance in the visible range. Therefore, this film can be used as a scattering layer for improving viewing angle characteristics and decreasing substrate mode loss in organic light-emitting diodes (OLEDs). Specifically, we focussed on varying the height and density of the RNRs to control the optical characteristics. As a result, the OLEDs with RNRs revealed a variation in colour coordinates of Δ(x, y) = (0.007, 0.014) for a change in the viewing angle, which was superior to those without the RNRs that displayed a variation of Δ(x, y) = (0.020, 0.034) in CIE 1931. Moreover, the OLEDs with RNRs exhibited 31% enhanced external quantum efficiency compared to those of the OLEDs with the bare substrate. The flexibility of the polymer used for the RNRs and the plasma treatment suggests that the RNRs can be applied to flexible OLED displays and lighting systems.
ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse
Authors: Sluch Valentin M. , Banks Angela , Li Hui , Crowley Maura A. , Davis Vanessa , Xiang Chuanxi , Yang Junzheng , Demirs John T. , Vrouvlianis Joanna , Leehy Barrett , Hanks Shawn , Hyman Alexandra M. , Aranda Jorge , Chang Bo , Bigelow Chad E. , Rice Dennis S.
Published: September 2018

The knockout (KO) of the adiponectin receptor 1 (AdipoR1) gene causes retinal degeneration. Here we report that ADIPOR1 protein is primarily found in the eye and brain with little expression in other tissues. Further analysis of AdipoR1 KO mice revealed that these animals exhibit early visual system abnormalities and are depleted of RHODOPSIN prior to pronounced photoreceptor death. A KO of AdipoR1 post-development either in photoreceptors or the retinal pigment epithelium (RPE) resulted in decreased expression of retinal proteins, establishing a role for ADIPOR1 in supporting vision in adulthood. Subsequent analysis of the Mfrprd6 mouse retina demonstrated that these mice are lacking ADIPOR1 in their RPE layer alone, suggesting that loss of ADIPOR1 drives retinal degeneration in this model. Moreover, we found elevated levels of IRBP in both the AdipoR1 KO and the Mfrprd6 models. The spatial distribution of IRBP was also abnormal. This dysregulation of IRBP hypothesizes a role for ADIPOR1 in retinoid metabolism.
Noncollinear and nonlinear pulse propagation
Authors: Kardaś Tomasz M. , Stepanenko Yuriy , Radzewicz Czesław
Published: September 2018

A novel method for numerical modelling of noncollinear and nonlinear interaction of femtosecond laser pulses is presented. The method relies on a separate treatment of each of the interacting pulses by it’s own rotated unidirectional pulse propagation equation (UPPE). We show that our method enables accurate simulations of the interaction of pulses travelling at a mutual angle of up to 140°. The limit is imposed by the unidirectionality principal. Additionally, a novel tool facilitating the preparation of noncollinear propagation initial conditions - a 3D Fourier transform based rotation technique - is presented. The method is tested with several linear and nonlinear cases and, finally, four original results are presented: (i) interference of highly chirped pulses colliding at mutual angle of 120°, (ii) optical switching through cross-focusing of perpendicular beams (iii) a comparison between two fluorescence up-conversion processes in BBO with large angles between the input beams and (iv) a degenerate four-wave mixing experiment in a boxcar configuration.
Electrostatic potential and valence modulation in La0.7Sr0.3MnO3 thin films
Authors: Trappen Robbyn , Garcia-Castro A. C. , Tra Vu Thanh , Huang Chih-Yeh , Ibarra-Hernandez Wilfredo , Fitch James , Singh Sobhit , Zhou Jinling , Cabrera Guerau , Chu Ying-Hao , LeBeau James M. , Romero Aldo H. , Holcomb Mikel B.
Published: September 2018

The Mn valence in thin film La0.7Sr0.3MnO3 was studied as a function of film thickness in the range of 1–16 unit cells with a combination of non-destructive bulk and surface sensitive X-ray absorption spectroscopy techniques. Using a layer-by-layer valence model, it was found that while the bulk averaged valence hovers around its expected value of 3.3, a significant deviation occurs within several unit cells of the surface and interface. These results were supported by first principles calculations. The surface valence increases to up to Mn3.7+, whereas the interface valence reduces down to Mn2.5+. The change in valence from the expected bulk value is consistent with charge redistribution due to the polar discontinuity at the film-substrate interface. The comparison with theory employed here illustrates how this layer-by-layer valence evolves with film thickness and allows for a deeper understanding of the microscopic mechanisms at play in this effect. These results offer insight on how the two-dimensional electron gas is created in thin film oxide alloys and how the magnetic ordering is reduced with dimensionality.
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
Authors: Al-Maskari Muna , Care Matthew A. , Robinson Emily , Cocco Mario , Tooze Reuben M. , Doody Gina M.
Published: September 2018

The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified by ATF6, undergo intramembrane-proteolysis by the sequential action of site-1 (MBTPS1/S1P) and site-2 proteases (MBTPS2/S2P) and release of the cytoplasmic domain as an active transcription factor. Such regulation is shared with a family of CREB3-related transcription factors and sterol regulatory element-binding proteins (SREBPs). Of these, we identify that the CREB3 family member CREB3L2 is strongly induced and activated during the transition from B-cell to plasma cell state. Inhibition of site-1 protease leads to a profound reduction in plasmablast number linked to induction of autophagy. Plasmablasts generated in the presence of site-1 protease inhibitor segregated into CD38high and CD38low populations, the latter characterized by a marked reduction in the capacity to secrete IgG. Site-1 protease inhibition is accompanied by a distinctive change in gene expression associated with amino acid, steroid and fatty acid synthesis pathways. These results demonstrate that transcriptional control of metabolic programs necessary for secretory activity can be targeted via site-1 protease inhibition during ASC differentiation.
Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons
Authors: Barrio-Alonso E. , Hernández-Vivanco A. , Walton C. C. , Perea G. , Frade J. M.
Published: September 2018

Cell cycle reentry followed by neuronal hyperploidy and synaptic failure are two early hallmarks of Alzheimer’s disease (AD), however their functional connection remains unexplored. To address this question, we induced cell cycle reentry in cultured cortical neurons by expressing SV40 large T antigen. Cell cycle reentry was followed by hyperploidy in ~70% of cortical neurons, and led to progressive axon initial segment loss and reduced density of dendritic PSD-95 puncta, which correlated with diminished spike generation and reduced spontaneous synaptic activity. This manipulation also resulted in delayed cell death, as previously observed in AD-affected hyperploid neurons. Membrane depolarization by high extracellular potassium maintained PSD-95 puncta density and partially rescued both spontaneous synaptic activity and cell death, while spike generation remained blocked. This suggests that AD-associated hyperploid neurons can be sustained in vivo if integrated in active neuronal circuits whilst promoting synaptic dysfunction. Thus, cell cycle reentry might contribute to cognitive impairment in early stages of AD and neuronal death susceptibility at late stages.
Long-term effects of H. pylori eradication on epigenetic alterations related to gastric carcinogenesis
Authors: Michigami Yuki , Watari Jiro , Ito Chiyomi , Nakai Keisuke , Yamasaki Takahisa , Kondo Takashi , Kono Tomoaki , Tozawa Katsuyuki , Tomita Toshihiko , Oshima Tadayuki , Fukui Hirokazu , Morimoto Takeshi , Das Kiron M. , Miwa Hiroto
Published: September 2018

The risk of gastric cancer (GC) remains in precancerous conditions, including atrophic mucosa and intestinal mucosa (IM), even after H. pylori treatment. To define the molecular changes following H. pylori eradication, molecular alterations in the gastric mucosa with and without GC were evaluated in a long-term follow-up study. A total of 232 biopsy specimens from 78 consecutive patients, including atrophic gastritis patients with follow-up ≥3 y after successful H. pylori eradication (AG group), patients who developed early GC after successful eradication (≥3 y) (GC group), and patients with H. pylori-positive atrophic gastritis (Hp group), were analyzed. H. pylori eradication was associated with significant reductions of methylation of several genes/loci in atrophic mucosa (non-IM), but not in IM. In contrast, the incidence of CpG island methylator phenotype (CIMP) in IM was significantly higher in the GC group than in the AG group. miR-124a-3 methylation and miR-34c methylation were more frequently identified in IM, with very few in non-IM mucosa among the three groups. H. pylori eradication can reverse methylation only in non-IM mucosa. CIMP in IM may have potential as a surrogate maker of GC development, and methylation of miR-124a-3 and miR-34c is a molecular event in IM that may not be associated with GC development.
The plasminogen binding protein PbsP is required for brain invasion by hypervirulent CC17 Group B streptococci
Authors: Lentini Germana , Midiri Angelina , Firon Arnaud , Galbo Roberta , Mancuso Giuseppe , Biondo Carmelo , Mazzon Emanuela , Passantino Annamaria , Romeo Letizia , Trieu-Cuot Patrick , Teti Giuseppe , Beninati Concetta
Published: September 2018

Streptococcus agalactiae (Group B Streptococcus or GBS) is a frequent cause of serious disease in newborns and adults. Epidemiological evidence indicates a strong association between GBS strains belonging to the hypervirulent CC17 clonal complex and the occurrence of meningitis in neonates. We investigate here the role of PbsP, a cell wall plasminogen binding protein, in colonization of the central nervous system by CC17 GBS. Deletion of pbsP selectively impaired the ability of the CC17 strain BM110 to colonize the mouse brain after intravenous challenge, despite its unchanged capacity to persist at high levels in the blood and to invade the kidneys. Moreover, immunization with a recombinant form of PbsP considerably reduced brain infection and lethality. In vitro, pbsP deletion markedly decreased plasmin-dependent transmigration of BM110 through brain microvascular endothelial cells. Although PbsP was modestly expressed in bacteria grown under standard laboratory conditions, pbsP expression was markedly upregulated during in vivo infection or upon contact with cultured brain endothelial cells. Collectively, our studies indicate that PbsP is a highly conserved Plg binding adhesin, which is functionally important for invasion of the central nervous system by the hypervirulent CC17 GBS. Moreover, this antigen is a promising candidate for inclusion in a universal GBS vaccine.
Shallow carbon storage in ancient buried thermokarst in the South Kara Sea
Authors: Portnov Alexey , Mienert Jürgen , Winsborrow Monica , Andreassen Karin , Vadakkepuliyambatta Sunil , Semenov Peter , Gataullin Valery
Published: September 2018

Geophysical data from the South Kara Sea reveal U-shaped erosional structures buried beneath the 50–250 m deep seafloor of the continental shelf across an area of ~32 000 km2. These structures are interpreted as thermokarst, formed in ancient yedoma terrains during Quaternary interglacial periods. Based on comparison to modern yedoma terrains, we suggest that these thermokarst features could have stored approximately 0.5 to 8 Gt carbon during past climate warmings. In the deeper parts of the South Kara Sea (>220 m water depth) the paleo thermokarst structures lie within the present day gas hydrate stability zone, with low bottom water temperatures −1.8 oC) keeping the gas hydrate system in equilibrium. These thermokarst structures and their carbon reservoirs remain stable beneath a Quaternary sediment blanket, yet are potentially sensitive to future Arctic climate changes.
Astaxanthin enhances erlotinib-induced cytotoxicity by p38 MAPK mediated xeroderma pigmentosum complementation group C (XPC) down-regulation in human lung cancer cells
Authors: Chen Jyh-Cheng , Wu Chia-Hung , Peng Yi-Shuan , Zheng Hao-Yu , Lin Yuan-Cheng , Ma Peng-Fang , Yen Ting-Chuan , Chen Tzu-Ying , Lin Yun-Wei
Published: September 2018

Astaxanthin has been demonstrated to exhibit a wide range of beneficial effects that include anti-cancer and anti-inflammatory properties.
Aggregation of P3HT as a preferred pathway for its chemical doping with F4-TCNQ
Authors: Tang Kan , McFarland Frederick M. , Travis Skye , Lim Jasmine , Azoulay Jason D. , Guo Song
Published: September 2018

In the chemical doping reaction of P3HT with F4-TCNQ, the aggregation of P3HT occurs before the charge transfer step.
An all-inorganic lead halide perovskite-based photocathode for stable water reduction
Authors: Gao Lin-Feng , Luo Wen-Jun , Yao Ying-Fang , Zou Zhi-Gang
Published: September 2018

An all-inorganic lead halide perovskite-based photocathode was prepared for high-performance and stable water reduction to generate hydrogen.
The temperature dependence of C–H⋯F–C interactions in benzene : hexafluorobenzene
Authors: Cockcroft Jeremy K. , Rosu-Finsen Alexander , Fitch Andrew N. , Williams Jeffrey H.
Published: September 2018

Variable temperature X-ray and neutron diffraction and simple ideas of intermolecular forces permit a rationalization of the 4 phases observed for the solid-state adduct of benzene and hexafluorobenzene.
Disorder in the hydrogen-atoms uninvolved in hydrogen bonds in a metal–organic framework
Authors: Viswanathan M.
Published: September 2018

Detailed investigations based on single-crystal neutron diffraction discloses disorder in the hydrogen atoms that do not participate in hydrogen bonding.
Dual plasmonically tunable slow light based on plasmon-induced transparency in planar graphene ribbon metamaterials
Authors: Xu Hui , Zhao Mingzhuo , Xiong Cuixiu , Zhang Baihui , Zheng Mingfei , Zeng Jianping , Xia Hui , Li Hongjian
Published: September 2018

We can achieve a very obvious dual plasmon induced transparency effect and obtain a good slow light property.
Large amplitude vibrations of acetyl isocyanate, methyl cyanoformate, and acetyl cyanate
Authors: Dalbouha Samira , Senent María L.
Published: September 2018

The far infrared region of three detectable molecules sharing the empirical formula C3H3O2N, acetyl isocyanate CH3CONCO (AISO), methyl cyanoformate NC–COOCH3 (MCN) and acetyl cyanate CH3COOCN (ACN), is explored using explicitly correlated coupled cluster ab initio methods and a variational procedure designed for non-rigid species and large amplitude motions.
Temperature-dependent crystalline structure and phase transition of poly(butylene adipate) end-functionalized by multiple hydrogen-bonding groups
Authors: Bao Jianna , Fan Huabo , Xue Xiaojia , Xie Qing , Pan Pengju
Published: September 2018

The crystallization kinetics, crystalline structure and phase transition of UPy-functionalized poly(butylene adipate) were investigated. UPy functionalization facilitated the formation of α crystals.
Synthesis and reactivity of selenium functionalised allylidynes and propargylidynes
Authors: Hill Anthony F. , Manzano Richard A. , Ward Jas S.
Published: September 2018

The reactions of the trimethylsilylpropargylidyne [W(CCCSiMe3)(CO)2(Tp*)] (1: Tp* = hydrotris(dimethylpyrazolyl)borate) towards selenium centred reagents when treated with tetrabutylammonium fluoride (TBAF) were explored in order to prepare alkynylselenolato propargylidynes, e.g., [W(CCCSePh)(CO)2(Tp*)].
The η1-H–C⋯Hg agostic interactions in the mercury complexes of N-confused porphyrin
Authors: Chen Yi-Chun , Tung Jo-Yu , Liu Ta-Kang , Tsai Wei-Joe , Lin Hsiang-Yin , Chang Yu-Chang , Chen Jyh-Horung
Published: September 2018

The bond path for the η1-H(17)–C(17)⋯Hg agostic interactions in 4–9 was a through-space interaction [Hg⋯C(17)] and a through-bond interaction [Hg⋯H(17)].
Quo vadishigh-resolution continuum source atomic/molecular absorption spectrometry?
Authors: Resano M. , García-Ruiz E. , Aramendía M. , Belarra M. A.
Published: September 2018

After more than a decade since its commercial introduction, high-resolution continuum source atomic/molecular absorption spectrometry may be facing a mid-life crisis.
Wirelessly activated device with an integrated ionic polymer metal composite (IPMC) cantilever valve for targeted drug delivery
Authors: Cheong Hau Ran , Nguyen Nam-Trung , Khaw Mei Kum , Teoh Boon Yew , Chee Pei Song
Published: September 2018

A wirelessly activated ionic polymer metal composite (IPMC) releases cisplatin drug from the device's orifice shows decrease of HeLa cell viability with RF turned on.
Reconstructing bimetallic carbide Mo6Ni6C for carbon interconnected MoNi alloys to boost oxygen evolution electrocatalysis
Authors: Zu Meng Yang , Wang Chongwu , Zhang Le , Zheng Li Rong , Yang Hua Gui
Published: September 2018

Mo6Ni6C is first utilized for the OER process, reconstructing in the bulk to form MoNi alloy nanoclusters interconnected with atomically dispersed carbon.
Oxotitanium-porphyrin for selective catalytic reduction of NO by NH3: a theoretical mechanism study
Authors: Daengngern Rathawat , Maitarad Phornphimon , Shi Liyi , Zhang Dengsong , Kungwan Nawee , Promarak Vinich , Meeprasert Jittima , Namuangruk Supawadee
Published: September 2018

Nitric oxide reduction catalyzed by oxotitanium-porphyrin.
Spin signatures in the electrical response of graphene nanogaps
Authors: García-Suárez Víctor M. , García-Fuente Amador , Carrascal Diego J. , Burzurí Enrique , Koole Max , van der Zant Herre S. J. , El Abbassi Maria , Calame Michel , Ferrer Jaime
Published: September 2018

We analyse the electrical response of narrow graphene nanogaps in search for transport signatures stemming from spin-polarized edge states.
Linear and nonlinear optical characteristics of all-inorganic perovskite CsPbBr3 quantum dots modified by hydrophobic zeolites
Authors: Li Ruxue , Wei Zhipeng , Zhao Haixia , Yu Hongrui , Fang Xuan , Fang Dan , Li Junzi , He Tingchao , Chen Rui , Wang Xiaohua
Published: September 2018

All-inorganic perovskite quantum dots (QDs) have been considered as outstanding candidates for high-performance optoelectronic device applications.
Azlactone-based heterobifunctional linkers with orthogonal clickable groups: efficient tools for bioconjugation with complete atom economy
Authors: Ho Hien The , Bénard Alexandre , Forcher Gwenaël , Le Bohec Maël , Montembault Véronique , Pascual Sagrario , Fontaine Laurent
Published: September 2018

New azlactone-based heterobifunctional linkers that proceed in orthogonal click-like reactions for chemical ligations in biologically relevant medium without releasing any byproduct.
Cyclic imines – preparation and application in synthesis
Authors: Iwanejko Jakub , Wojaczyńska Elżbieta
Published: September 2018

Cyclic imines, available from various nitrogen-containing reactants, serve as versatile synthetic intermediates for biologically active compounds.
Phosphinatophenylporphyrins tailored for high photodynamic efficacy
Authors: Hynek Jan , Koncošová Martina , Zelenka Jaroslav , Křížová Ivana , Ruml Tomáš , Kubát Pavel , Demel Jan , Lang Kamil
Published: September 2018

Porphyrin phosphinates are attractive candidates for photodynamic applications since their cellular uptake can be easily tuned by the substituent on phosphorus atoms.
Penetrating effect of high-intensity infrared laser pulses through body tissue
Authors: Han Danhong , Xu Jingjing , Wang Zhenhai , Yang Nana , Li Xunzhou , Qian Yingying , Li Ge , Dai Rujun , Xu Shengyong
Published: September 2018

Researchers have utilized infrared (IR) lasers as energy sources in laser therapy for curing skin diseases and skin injuries with remarkable effects.
A “Turn-On” fluorescent probe for sensitive and selective detection of fluoride ions based on aggregation-induced emission
Authors: Du Man , Huo Baolong , Li Mengwen , Shen Ao , Bai Xue , Lai Yaru , Liu Jiemin , Yang Yunxu
Published: September 2018

A “Turn-On” fluorescent probe PBT for sensitive and selective detection of fluoride ions based on aggregation-induced emission.
Novel easily available purine-based AIEgens with colour tunability and applications in lipid droplet imaging
Authors: Shi Lei , Li Kun , Li Ling-Ling , Chen Shan-Yong , Li Meng-Yang , Zhou Qian , Wang Nan , Yu Xiao-Qi
Published: September 2018

A new series of purine-based derivatives with easy availability and colour tunability were synthesized and could be used for lipid droplet imaging.
Formation of hollow MoO3/SnS2 heterostructured nanotubes for efficient light-driven hydrogen peroxide production
Authors: Zhang Yifan , Park Soo-Jin
Published: September 2018

Schematic illustration of the synthetic procedure for the hollow MoO3/SnS2 nanotubes.
Near-infrared AIEgen-functionalized and diselenide-linked oligo-ethylenimine with self-sufficing ROS to exert spatiotemporal responsibility for promoted gene delivery
Authors: Huang Yongkang , Chen Qixian , Lu Hongguang , An Jinxia , Zhu Huajie , Yan Xiangjie , Li Wei , Gao Hui
Published: September 2018

We attempted to synthesize an oligo-ethyleneimine (OEI)-crosslinked polycation, characterized with self-sufficing ROS by virtue of a functional AIE component and an ROS-labile diselenide linkage.
An accurate and cost-effective alternative method for measuring cell migration with the circular wound closure assay
Authors: De Ieso Michael L. , Pei Jinxin Victor
Published: September 2018

Cell migration is important in many physiological and pathological processes. Mechanisms of two-dimensional cell migration have been investigated most commonly by evaluating rates of cell migration into linearly scratched zones on the surfaces of culture plates. Here, we present a detailed description of a simple adaptation for the well-known and popular wound closure assay, using a circular wound instead of a straight line. This method demonstrates improved precision, reproducibility, and sampling objectivity for measurements of wound sizes as compared with classic scratch assays, enabling more accurate calculations of migration rate. The added benefits of the method are simplicity and low cost as compared with commercially available assays for generating circular wounds.
Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats
Authors: Qiao Hongjie , Zhang Yuanyuan , Lin Wenwen , Wang Yu-Feng , Furdui Cristina M. , Jiang Qiuling , Li Xiao , Long Ting , Wang Yunguang , Qin Da-nian
Published: September 2018

Increased production of reactive oxygen species (ROS) and inflammation are major contributors to the development and progression of diabetes-associated erectile dysfunction (DMED). As an endogenous antioxidant and anti-inflammatory factor, the potential implication of pigment epithelium-derived factor (PEDF) in DMED has not been revealed. To assess the potential antioxidant and anti-inflammatory functions of PEDF in DMED, we first demonstrated that PEDF was significantly decreased at the levels of the mRNA and protein in the penis of diabetic rats compared with normal controls. To test the hypothesis that decreased the penile levels of PEDF are associated with oxidative stress and inflammation in DMED, an adenovirus expressing PEDF (Ad-PEDF) or the same titer of control virus (Ad-GFP) was intracavernously administered at 2 weeks after diabetic onset. After 6 weeks of treatment, we found that administration of Ad-PEDF could significantly increase erectile response to cavernosal nerve stimulation in the diabetic rats by restoring the endothelial NO synthase (eNOS), P-eNOS, and neuronal NO synthase (nNOS) protein levels to the standard levels represented in normal rats and by suppressing the levels of tumor necrosis factor-α (TNF-α) and oxidative stress. In conclusion, the present data indicated that the antioxidant and anti-inflammatory potential of PEDF plays important role in restoring erectile function by the inhibition of oxidative stress and TNF-α production.
Electro‐optic filter based on guided‐mode resonance for optical communication
Authors: Ren Zhibin , Sun Yahui , Hu Jiasheng , Zhang Shuqing , Lin Zihao , Zhi Xiyang
Published: September 2018

An electro‐optic filter based on guided‐mode resonance for optical communication has been designed and fabricated. The rigorous coupled‐wave analysis is used to calculate the reflection spectra of the designed filter. The grating structure of the filter is patterned by interference lithography with two ultraviolet laser beams. The polymer‐dispersed liquid crystal is injected into the gap between the glass substrate and the bottom of the grating to fabricate the electro‐optic filter. The measured spectra of the fabricated filter exhibit a 38.7 nm shift of the resonant reflected wavelength by controlling the applied voltage.
Social‐aware incentive mechanism for full‐view covered video collection in crowdsensing
Authors: Pei Yingying , Hou Fen
Published: September 2018

Compared with a traditional fixed sensor network, mobile crowdsensing provides an efficient way to collect sensing data. However, conducting sensing tasks consumes the resources of mobile users (e.g. battery, storage memory, time). Therefore, incentive mechanism design plays a key role in efficiently collecting the sensing data in a mobile crowdsensing system. Most of existing works about the incentive mechanism design simply use a constant to describe the data quality. In this study, the authors focus on the collection of video clips and introduce multiple parameters to evaluate the quality of the collected data. By jointly considering the social relationship of mobile users, they propose a social‐aware incentive mechanism to achieve the full‐view coverage for a target by efficiently collecting video clips. The proposed mechanism satisfies the properties of individual rationality, truthful and computational efficiency. Simulation results show better performance of the proposed mechanism compared with random selection and aspect based selection. In specific, with the number of users , the proposed mechanism can improve the data collector's utility by 485% and 33% compared with random selection and aspect based selection, respectively.
A new X-ray-selected sample of very extended galaxy groups from the ROSAT All-Sky Survey
Authors: Xu Weiwei , Ramos-Ceja Miriam E. , Pacaud Florian , Reiprich Thomas H. , Erben Thomas
Published: September 2018

Context.Some indications for tension have long been identified between cosmological constraints obtained from galaxy clusters and primary cosmic microwave background (CMB) measurements. Typically, assuming the matter density and fluctuations, as parameterized with Ωmandσ8, estimated from CMB measurements, many more clusters are expected than those actually observed. This has been reinforced recently by the Planck collaboration. One possible explanation could be that certain types of galaxy groups or clusters were missed in samples constructed in previous surveys, resulting in a higher incompleteness than estimated.

Aims.In this work, we aim to determine if a hypothetical class of very extended, low-surface-brightness galaxy groups or clusters have been missed in previous X-ray cluster surveys based on the ROSAT All-Sky Survey (RASS).

Methods.We applied a dedicated source-detection algorithm sensitive also to more unusual group or cluster surface-brightness distributions. It includes a multiresolution filtering, a source-detection algorithm, and a maximum-likelihood fitting procedure. To optimize parameters, this algorithm is calibrated using extensive simulations before it is used to reanalyze the RASS data. In addition, the cross-correlation of the candidates with optical/infrared surveys is used for cluster identification and redshift estimation.

Results.We found many known groups but also a number of new group candidates, which are not included in any previous X-ray or SZ cluster catalogs. In this paper, we present a pilot sample of 13 very extended groups discovered in the RASS at positions where no X-ray source has been detected previously and with clear optical counterparts. The X-ray fluxes of at least 5 of these are above the nominal flux-limits of previous RASS cluster catalogs (≳3 × 10−12erg s−1cm−2in the 0.1 − 2.4 keV energy band). They have low mass (1013M⊙≲M500≲ 1014M⊙; i.e., they are galaxy groups), are at low redshift (z< 0.08), and exhibit flatter surface-brightness distributions than usual.

Conclusions.We demonstrate that galaxy groups were missed in previous RASS surveys, possibly due to the flat surface-brightness distributions of this potential new population. Analysis of the full sample will show if this might have a significant effect on previous cosmological parameter constraints based on RASS cluster surveys.
The demographics of neutron star – white dwarf mergers
Authors: Toonen S. , Perets H. B. , Igoshev A. P. , Michaely E. , Zenati Y.
Published: September 2018

Context. The mergers of neutron stars (NSs) and white dwarfs (WDs) could give rise to explosive transients, potentially observable with current and future transient surveys. However, the expected properties and distribution of such events is not well understood.

Aims. Here we characterise the rates of such events, their delay-time distributions, their progenitors, and the distribution of their properties.

Methods. We use binary population synthesis models and consider a wide range of initial conditions and physical processes. In particular we consider different common-envelope evolution models and different NS natal kick distributions. We provide detailed predictions arising from each of the models considered.

Results. We find that the majority of NS–WD mergers are born in systems in which mass-transfer played an important role, and the WD formed before the NS. For the majority of the mergers the WDs have a carbon-oxygen composition (60−80%) and most of the rest are with oxygen-neon WDs. The time-integrated rates of NS–WD mergers are in the range of 3−15% of the type Ia supernovae (SNe) rate. Their delay-time distribution is very similar to that of type Ia SNe, but is slightly biased towards earlier times. They typically explode in young 100 Myr < τ < 1 Gyr environments, but have a tail distribution extending to long, gigayear-timescales. Models including significant kicks give rise to relatively wide offset distribution extending to hundreds of kiloparsecs.

Conclusions. The demographic and physical properties of NS–WD mergers suggest they are likely to be peculiar type Ic-like SNe, mostly exploding in late-type galaxies. Their overall properties could be related to a class of recently observed rapidly evolving SNe, while they are less likely to be related to the class of Ca-rich SNe.
Measuring precise radial velocities on individual spectral lines
Authors: Dumusque X.
Published: September 2018

Context. Stellar activity is the main limitation to the detection of an Earth-twin using the radial-velocity (RV) technique. Despite many efforts in trying to mitigate the effect of stellar activity using empirical and statistical techniques, it seems that we are facing an obstacle that will be extremely difficult to overcome using current techniques.

Aims. In this paper, we investigate a novel approach to derive precise RVs considering the wealth of information present in high-resolution spectra.

Methods. This new method consists of building a master spectrum from all available observations and measure the RVs of each individual spectral line in a spectrum relative to this master. When analysing several spectra, the final product of this approach is the RVs of each individual line as a function of time.

Results. We demonstrate on three stars intensively observed with HARPS that our new method gives RVs that are extremely similar to the one derived from the HARPS data reduction software. Our new approach to derive RVs demonstrates that the non-stability of daily HARPS wavelength solution induces night-to-night RV offsets with an standard deviation of 0.4 m s−1, and we propose a solution to correct for this systematic. Finally, and this is probably the most astrophysically relevant result of this paper, we demonstrate that some spectral lines are strongly affected by stellar activity while others are not. By measuring the RVs on two carefully selected subsample of spectral lines, we demonstrate that we can boost by a factor of two or mitigate by a factor of 1.6 the red noise induced by stellar activity in the 2010 RV measurements of α Cen B.

Conclusions. By measuring the RVs of each spectral line, we are able to reach the same RV precision as other approved techniques. In addition, this new approach allows us to demonstrate that each spectral line is differently affected by stellar activity. Preliminary results show that studying in details the behaviour of each spectral line is probably the key to overcome the obstacle of stellar activity.
Study of Excavation Stability and Treatment Measures of the Side Slope of Anti-Dip Bedding Highway
Authors: Shen Qian , Liu Liu , Yuan Jinxiu
Published: September 2018

In order to improve the slope safety of the side slope of anti-dip bedding highway, this paper analyzes the stability of the excavation by using the finite difference numerical simulation technique. The development process of the disaster under the three excavation conditions and the whole process of the slip surface of the anti dip bedding rock slope are revealed; The method of determining the potential slip surface is introduced, that is to say, the slope is unstable and slip by reducing the material parameters of the slope, and then the position of the slip surface is judged by the difference of the displacement value. The research results have important significance for understanding the development mechanism of slope disaster and adopting corresponding engineering measures for different stages of slope.
Finite Difference Method in Stress Analysis of Anchorage Zone of Highway Extradosed Cable Stayed Bridge
Authors: Tang Yingying , Li Yingshuai , Niu Yanwei , Chen Hong , Pingming Huang
Published: September 2018

With the development and wide application of extradosed cable stayed bridge, an effective method is needed for simulation of the stress distribution in anchorage zone, which plays a vital role in transferring force from the cable to the pylon and diverting the cable direction. Based on the Finite Difference Method (FDM), an efficient and practical method of stress filed simulation was presented in the paper. First, a plane finite element model was established using ABAQUS, to determine the boundary condition for FDM. Based on this, FDM was used to simulate the stress distribution of the concrete in the anchorage zone. Finally, on the simulation result was calculated and in comparison with finite element model result. It has been found that: The vertical compressive stress of concrete in the anchorage zone gradually reduces from the middle to the two sides, and the stress assumes double peak type in transverse. Compared with the finite element solutions, the approximate solution simulated by FDM improve the computational efficiency with certain accuracy keeping, except the loading area. In vertical orientation, the concrete in the place of H (the width of the pylon) from cable force acting position is in a state of uniform stress.
Monitoring of Daily Temperature Effect on Deck Deformation of Concrete Arch Bridge
Authors: Tang Yingying , Wang Yong’e , Niu Yanwei , Chen Hong , Pingming Huang
Published: September 2018

Temperature makes greatly differences on concrete in many aspects, including stress, strain and deformation, especially for arch concrete bridge structure. Some software can compute theoretical deformation, stress and bending moment of bridge structure due to temperature load, such as Midas Civil. In recent years, in order to learn about conditions of structure, many bridges have installed the healthy monitoring system. In this research, the monitoring data lasting approach a year was obtained from Haierwa Bridge, a concrete truss arch bridge, in Hebei province. The bridge belongs to Xuanda Highway, which undertook the main traffic flow of coal transportation. The proportion of heavy vehicles, exceeding 50t, ups to 30%, different with common highway. The objective of this paper is to monitor and analyse the deformation of concrete truss arch bridge due to air temperature change. Firstly, results show that the daily tendencies of temperature and bridge vertical deformation at mid-span, L/4 and arch foot in the winter and summer. The linear relationship was calculated between the temperature and deformation of critical sections based on the monitoring data. In addition, the finite element model was established to calculate the theoretical value, and further compared with practice values.
The Numerical Investigation of Aluminum Foam-protected Reinforced Concrete Slabs under Blast Loading Using AUTODYN-3D
Authors: Taha Ahmed K. , Gao Zhengguo , Huang Dahai
Published: September 2018

Aluminum foam is a lightweight material with high energy absorption capacity. In this study A Nonlinear three-dimensional hydrocode numerical simulation was carried out using autodyn-3d, which is an extensive code dealing with explosion problems. In this simulation, a high explosive material (comp B) is blasted against several concrete panels. The model was first validated using experimental tests carried out by Chengqing and has shown good results. Several numerical tests were carried out to study two parameters that affect the deflection of reinforced concrete panels. The parameters included are the thickness of concrete target and the thickness of steel plate. The results showed that increasing the thickness of the steel plate has an insignificant effect on the deflection of the reinforced concrete target while increasing the thickness of the concrete panel has a significant effect on the deflection of the concrete target.
Effects of Shrinkage Reducing Agent and Expansive Additive on Plastic Shrinkage of Mortar at Different Temperatures
Authors: Treesuwan Sarapon , Maleesee Komsan , Date Shigeyuki
Published: September 2018

In the construction, it is inevitable to perform plaster work in hot weather which causes the dehydration and rapid shrinkage on the paste during the early age. This research shows the studies of reducing the plastic shrinkage of mortar during the early age with such additives as the Shrinkage Reducing Agent (SRA), the Expansive Additive (EX), and the Fly Ash (FA) in controlled temperatures at 30°C and 40°C, with relative humidity between 60% and 70% according to the ASTM C1579-06 standard, with the strain gauge installed at 0.5 cm.from the surface. The shrinkage rate was measured starting from the Initial Setting Time and every 10 minutes afterwards for 24 hours. The results show that high temperature effects the cracking and how to use different formulas of additive under different circumstances is considerably important. To use only one additive is not sufficient in high temperature. To use the SRA in addition to the EX enhances better expansion than to use only the EX. Moreover, it is recommended to pay close attention in adding large amount of the FA into mortar with the EX and SRA added which extremely enhances the expansion and potential cracking.
Design Experiment for Leveraging Material Value Coal Ash as Material Mixture of Paving Block
Authors: Fernanto Harris Setyo , Gabriel Djoko Sihono
Published: September 2018

The coal-fired thermal power plant is the main source of coal ash production. Coal ash collected at the bottom of the furnace (boiler) is called coal bottom ash (CBA) and fly ash remaining combustion called coal fly ash (CFA). In Indonesia, the utilization of bottom ash and fly ash generally is still limited to landfill material due to the value of the material too low. The objective of this research is to leverage the value of the utilization of bottom ash and fly ash materials as a mixer of construction industry products. Design of Experiment (DoE) was conducted on paving block product using various experimental factors such as composition of sand, cement, bottom ash, fly ash, and curing period of product. This Design of Experiment (DoE) applied orthogonal array to finding the best mixed compositions that affect the quality of the end result. After it, the proof was performed with a compressive strength test and water absorption test to meet the standard requirements. Testing compressive strength of paving block was done at 7 days, 14 days and 28 days to get the best result.
Les multiples rôles de la protéine Core du virus de l’hépatite B
Authors: Chabrolles Hélène , Lahlali Thomas , Auclair Héloïse , Salvetti Anna
Published: September 2018

L’infection par le virus de l’hépatite B (HBV) constitue un problème majeur de santé publique avec plus de 250 millions de personnes chroniquement infectées au niveau mondial, qui présentent un risque important d’évolution vers la cirrhose et le cancer du foie. Les traitements disponibles permettent de réduire la réplication virale mais pas d’éliminer le virus. Il est donc primordial de développer de nouvelles thérapies antivirales. Des modulateurs allostériques (ou CAM), qui interfèrent avec les fonctions structurales de Core, la protéine de capside du virus, sont actuellement en évaluation clinique. L’étude des fonctions régulatrices de la protéine Core pourrait également permettre d’identifier des agents ciblant l’hôte et de développer des thérapies combinées pour un meilleur contrôle de la réplication virale.
Observance et nouvelles technologies : nouveau regard sur une problématique ancienne
Authors: Postel-Vinay Nicolas , Reach Gérard , Eveillard Philippe
Published: September 2018

En médecine, l’un des intérêts des nouvelles techniques de l’information et de la communication réside dans l’efficacité et la sécurité des traitements, sans méconnaître le fait que tous les patients ne pourront pas bénéficier de ces techniques, faute de pouvoir les maîtriser.
Prévention du suicide et santé connectée
Authors: Berrouiguet Sofian , Le Moal Valérie , Guillodo Élise , Le Floch Alis , Lenca Philippe , Billot Romain , Walter Michel
Published: September 2018

L’évaluation ponctuelle du risque suicidaire habituellement conduite aux urgences, après un geste suicidaire, ne rend pas compte de son évolution après la sortie des soins, alors même que le risque de récidive reste important plusieurs mois après. Dans ces conditions, les possibilités d’identification, et donc de prise en charge, des patients à risque suicidaire sont limitées. Le développement de la santé connectée (eHealth) donne désormais accès en temps réel à des informations sur l’état de santé d’un patient entre deux séjours en centre de soins. Cette extension de l’évaluation clinique à l’environnement du patient permet de développer des outils d’aide à la décision face à la gestion du risque suicidaire.
Taenia solium cysticercosis in West Africa: status update
Authors: Melki Jihen , Koffi Eugène , Boka Marcel , Touré André , Soumahoro Man-Koumba , Jambou Ronan
Published: September 2018

Cysticercosis is caused by the larvae of the cestode Taenia solium. Few data are available on the prevalence of this disease in pigs and humans in West African countries. The aim of this study was to provide an overview of existing data concerning the spread of this parasitosis in the countries of the Economic Community of West African States (ECOWAS) on the basis of the literature published over the last five decades. Systematic searches for publications were carried out on PubMed and Google Scholar, as well as in certain regional and local journals. From a total of 501 articles initially retrieved concerning T. solium cysticercosis in West African countries, only 120 articles were relevant for this review and therefore finally retained. For pigs, only eight out of sixteen countries of the region have reported porcine cysticercosis. Post-mortem examination of carcasses at slaughterhouses, meat inspection at butcheries or tongue inspection in herds have been the main source of data, but may not entirely reflect actual parasite distribution. For humans, only five out of sixteen countries reported epidemiological data on neurocysticercosis. Most data referred to neurocysticercosis prevalence among epileptic patients or isolated clinical cases. Furthermore, existing data are often old. Overall, T. solium cysticercosis remains largely neglected in West Africa, and its prevalence appears not to be affected by any religion in particular. There is an urgent need to promote and implement health partnerships and programs on this disease in order to collect more data and identify sensitive populations in the countries of the ECOWAS area.
Myelodysplastische Syndrome
Authors: Strupp Corinna , Schuck Anna , Haas Rainer
Published: September 2018

Myelodysplastische Syndrome (MDS) sind Knochenmarkerkrankungen einer klonal entarteten hämatopoietischen Stamm- oder Progenitorzelle, die zu einer ineffektiven
Hämatopoiese führen und mit einem erhöhten Risiko für einen Übergang in eine akute myeloische Leukämie einhergehen. MDS treten meist im höheren Lebensalter auf
und haben einen individuell sehr unterschiedlichen Krankheitsverlauf. Mittels einer zytologischen, zytogenetischen und histologischen Untersuchung des
Knochenmarks wird die Diagnose gestellt. Patienten mit Niedrigrisiko erhalten in palliativer Intention unter anderem Transfusionen mit Blutprodukten, ggf. eine
Eisenchelation, Erythropoetin bei niedrigem endogenen Erythropoetin-Spiegel und Lenalidomid beim Vorliegen einer 5q- Deletion. Demgegenüber kommt für Patienten
mit Hochrisiko-Konstellation in einem Alter von 65–70 Jahren ohne relevante Komorbidität eine allogene Blutstammzelltransplantation in kurativer Intention in
Frage. Patienten die nicht für eine Transplantation in Frage kommen, können in palliativer Intention mit der hypomethylierenden Substanz 5-Azacitidine behandelt
werden.
Electrophilic Sulfoximidations of Thiols by Hypervalent Iodine Reagents
Authors: Wang Han , Zhang Duo , Cao Mengwei , Bolm Carsten
Published: September 2018

A new electrophilic sulfoximidation of thiols has been developed. Using sodium hydride as a base, the treatment of sulfoximidoyl-containing hypervalent iodine(III) reagents with thiols affords the corresponding N-sulfenylsulfoximines (N-thiosulfoximines) in good to excellent yields. A plausible mechanism is proposed.