bluuebunny/crossref_metadata_2025 huggingface dataset:
A supervisão clínico-institucional como dispositivo de qualificação na Atenção Psicossocial: uma experiência de parceria com a Universidade
Authors: LIMA CLAUDIA HENSCHEL DE , SAMPAIO THALLES CAVALCANTI DOS SANTOS MENDONÇA , CUNHA JULIA DA SILVA
Published: November 2019

Resumo Apresenta-se a condução da supervisão clínico-institucional em um centro de atenção psicossocial localizado no município de Volta Redonda, no estado do Rio de Janeiro, resultando de projeto de extensão que vigorou entre os anos de 2012 e 2015, em uma universidade localizada no mesmo município. O processo de reforma psiquiátrica no município é apresentado a partir de duas interrogações do projeto de extensão: Em que momento da reforma psiquiátrica se encontra o município de Volta Redonda? Que clínica fora possível, até aquele momento, no CAPS? A partir dessas interrogações, descreveu-se o processo da supervisão clínico-institucional, destacando a psicanálise como marco teórico principal na análise sobre a forma como o cotidiano dos usuários do CAPS-II se situa no horizonte da reforma psiquiátrica, sobre o papel da psiquiatria no CAPS e na construção de um saber alternativo à psiquiatria, que considere a relevância da teoria, da posição subjetiva dos usuários e do saber dos profissionais. Destaca-se, ao final, a relevância da parceria com a universidade, como espaço de formação e reflexão crítica permanente sobre a oferta de serviços em saúde mental no horizonte da reforma psiquiátrica.
Sociocultural descriptions of febrile syndromes in rural areas of Urabá, Colombia: An exploration of “tick fever”
Authors: VÉLEZ JUAN CARLOS QUINTERO , MIGNONE JAVIER , QUINTERO LISARDO OSORIO , ARBELÁEZ CARLOS ROJAS
Published: November 2019

Abstract Introduction: In 2006 and 2008 there were two lethal outbreaks of rickettsioses in the rural areas of Urabá, characterized by the lack of immediate diagnosis and antibiotic treatment. Objective: Describe sociocultural aspects about knowledge, attitudes and practices in relation to febrile syndromes and “tick fever” in rural areas of Urabá. Materials and methods: We conducted an exploratory study using knowledge, attitudes, and practices questionnaires and semi-structured interviews about febrile syndromes and “tick fever”. We surveyed 246 heads of households and interviewed nine individuals. Results: We observed that people tended to identify febrile syndromes with signs and clinical symptoms of dengue, malaria, leptospirosis and rickettsioses. A considerable proportion of individuals (32.93%) knew very little about “tick fever”, thinking that is was transmitted by mosquitos. They mentioned intestinal parasitoids, malaria, dengue, and “evil eye” among the causes of febrile syndromes. “Tick fever” is linked by its name to the bite of the tick. Furthermore, the treatments for febrile syndromes mentioned by interviewees are associated to those commonly used in western medicine and medicinal plants. Conclusions: There is a need for educational programs in rural areas, to raise awareness about these potential lethal conditions that can be effectively treated.
Avaliação dos sistemas metroviários nas emissões de CO2: análise comparativa das emissões por automóveis, ônibus e metrôs
Authors: Andrade Carlos Eduardo Sanches de , D’Agosto Márcio de Almeida
Published: November 2019

RESUMO O setor de transportes é responsável por uma parcela das emissões globais de dióxido de carbono (CO2). Os estudos científicos publicados sobre emissões de CO2 pelos sistemas de transportes de passageiros tratam basicamente de resultados envolvendo apenas as emissões relacionadas ao consumo dos combustíveis dos automóveis e ônibus. Nos metrôs, geralmente são consideradas as emissões relacionadas à geração da energia elétrica necessária para prover a força de tração dos trens. Não foram identificadas publicações específicas ou padronizadas sobre outras abordagens de cálculos das emissões pelos metrôs. Com isso, este estudo visa fornecer uma contribuição científica no estudo geral das emissões de CO2 pelos metrôs, definindo conceitualmente cinco abordagens de cálculos e realizando uma análise comparativa dos resultados das emissões de CO2 por automóveis, ônibus e metrôs. O resultado desta pesquisa permitiu quantificar a real contribuição dos metrôs quanto à redução das emissões totais do setor de transportes. Na abordagem da energia de tração dos trens, concluiu-se que os Metrôs de São Paulo e Rio de Janeiro emitem 63,5 vezes menos do que os automóveis e 8 vezes menos do que os ônibus.
Espartanos e atenienses na escola: da filologia clássica à educação nacional nos Estados modernos europeus
Authors: Silva Rafael Guimarães Tavares da
Published: November 2019

Resumo No período de consolidação dos Estados Nacionais europeus industrializados, principalmente no fim do século XIX e início do século XX, os estudos clássicos foram incorporados ao modelo educacional responsável pela formação patriótica de seus futuros cidadãos. Refletindo acerca dessa dimensão educativa e política, vários classicistas do período voltaram suas pesquisas para uma compreensão dos modelos pedagógicos aplicados pelas bem-sucedidas civilizações antigas (como a Atenas ou a Esparta do período clássico) a fim de propor novos caminhos para os desafios do presente: dessa forma se dão a ler algumas das reflexões de Girard (1889), Wilamowitz-Moellendorf (1901; 1914-5), Freeman (1907) e Jaeger (2013). Esse impulso pedagógico esteve intimamente ligado às conjunturas sócio-políticas da época – responsáveis, inclusive, pelo movimento que culminou nas duas Guerras Mundiais, entre 1914 e 1945. Cumpre lembrar que formas violentas de controle estatal, manifestadas principalmente enquanto prerrogativas policiais e carcerárias, unidas a formas mais sutis de poder – por meio da educação obrigatória, por exemplo –, estão entre os fatores que contribuíram para um acirramento das tensões entre os Estados Nacionais na época. Tal como sugerido pelos estudos de Luciano Canfora, François Hartog e Suzanne Marchand, a filologia clássica acabou se revelando um front entre os muitos outros que entraram em disputa nesse complicado período histórico. O objetivo deste artigo é compreender esse processo e suas consequências para o desenvolvimento do campo dos estudos clássicos.
Do amor como falta: uma abordagem pedagógica
Authors: Franzi Juliana , Araújo Ulisses Ferreira de
Published: November 2019

Resumo No presente artigo assumimos o objetivo de elucidar a relevância de se tomar o amor como falta enquanto objeto de estudo da educação escolar, abordando-o, especialmente a partir da educação moral. Para tanto, partimos de uma revisão bibliográfica sobre o tema, evidenciando a tensão entre razão e emoção que permeou a compreensão sobre o amor, bem como a valorização do amor marcado pela falta. Em contraposição a tais entendimentos, enfatizamos uma perspectiva que compreende que o amor requer retribuição, tratando-se, portanto, de uma relação que não se sustenta unilateralmente e, de igual modo, salientamos a necessidade do autoconhecimento, do autocuidado e da autoestima. Com base em tais apontamentos, destacamos a importância de uma abordagem pedagógica sobre o tema e explicitamos as justificativas e os possíveis caminhos metodológicos e epistemológicos que sustentam uma abordagem pedagógica acerca do amor, entendendo, pois, que a educação formal apresenta-se como um terreno profícuo para que a afetividade seja trabalhada de maneira pedagógica, visando favorecer a tomada de consciência acerca dos sentimentos e das ações que pautem a vivência de relações afetivas e amorosas mais justas e igualitárias. Nessa direção, apontamos o amor como um tema transversal e interdisciplinar do currículo escolar, que colabora para a educação moral. Para tanto, dentre outros reconhecidos caminhos, daremos enfoque à metodologia da resolução de conflitos e à estratégia de projetos.
Effect of endoparasites occurrence in sows from intensive production system
Authors: Oliveira Newton Tavares Escocard de , Carvalho Paulo Levi de Oliveira , Genova Jansller Luiz , Silveira Fábio Henrique Rodrigues , Ogawa Liza , Cristofori Eliseu Carlos , Caxias Junior Osíris Antunes de , Santana Ana Lúcia Almeida
Published: November 2019

Abstract The goal of this study was to assess the effect of farm size (FS) and farrowing order (FO) on the occurrence of endoparasites eggs in commercial sows housed in maternity and gestation areas during the period from May to July 2014. Forty-three piglet production units were classified by FS: small (100 to 250 sows), medium (251 to 510 sows), large (511 to 1,000 sows) and very large (more than 1,000 sows). Sows were classified by FO: up to two, three to five or more than five parturitions. Faecal samples were processed using the simple flotation technique in a hypersaturated salt solution (30-35% NaCl). The results revealed that the overall prevalence of gastrointestinal endoparasites obtained in this study was 12.47%, in that 4.64% were positive for Ascaris suum, 0.56% for Trichuris suis and 8.27% for coccidia oocysts. The prevalence of endoparasites obtained for small and medium size farm, and for large and very large farm was 34.58% and 15.52%, respectively. In conclusion, the study shows that more than half of the farms were positive for A. suum and coccidia oocysts, but mainly for younger females. In general, sows with up to two parturitions and small farms showed a higher endoparasites percentage.
Implication of the fecal egg count reduction test (FECRT) in sheep for better use of available drugs
Authors: Salgado Jordana Andrioli , Cruz Letícia Vidal , Rocha Letícia Oliveira da , Sotomaior Cristina Santos , Borges Tâmara Duarte , Santos Clóvis de Paula
Published: November 2019

Abstract The aim here is to present data on the efficacy of anthelmintics in sheep flocks in Rio de Janeiro, Brazil, and to discuss the interpretation of the fecal egg count reduction test (FECRT) for each nematode genus. Fecal eggs counts and pre- and post-treatment coprocultures were performed, the former to evaluate the efficacy of and the latter to determine the overall parasite prevalence. An additional efficacy test was performed at Farm # 1 a year after the initial test. Severe anthelmintic resistance was found for the flocks, with no FECRT sensitivity at any of the 22 farms evaluated. However, an analysis of the infective larvae showed that some drugs were effective against certain parasitic genera; i.e., levamisole was more effective against Haemonchus spp. and moxidectin against Trichostrongylus spp. In the additional FECRT performed at Farm # 1, moxidectin and nitroxynil were ineffective separately, but when applied in combination they were highly effective due to their efficacy against Haemonchus (nitroxynil) and Trichostrongylus (moxidectin), respectively. The use of the FECRT targeting the parasitic nematode species prevalent on farms may make it possible to choose more effective anthelmintics.
Integrated tick control on a farm with the presence of capybaras in a Brazilian spotted fever endemic region
Authors: Araújo Shirley Batista de , Anjos Karina Araújo dos , Duarte Fernanda Calvo , Fiorini Leonardo Costa , Godoi Felipe Eduardo de Matos , Sampaio Paulo Henrique Selbmann , Mendes Márcia Cristina
Published: November 2019

Abstract Ticks of the Amblyomma cajennense complex present high infestation rates. These ticks transmit the bacterium Rickettsia rickettsii, which causes Brazilian Spotted Fever. For this reason, an integrated tick control system was adopted on a farm in the municipality of Itu, state of São Paulo. On this farm, which borders the Tietê river, domestic animals are in contact with populations of capybaras. Six locations were monitored and evaluated between the years of 2015 and 2017. During this work 1271 nymphs and adult ticks were caught, all of them from the Amblyomma sculptum species, except for a single individual from the Amblyomma dubitatum species. The integrated tick management reduced the overall infestation levels to zero. Adult tick population dropped in the first year of the study, while larvae population dropped in the second year. Nymph population dropped in both years, decreasing in higher numbers in the first year. The estimated mean infestation levels for all of the tick’s life cycle forms in the six monitored spots did not reach one individual in the end of the study. Estimated mean infestation levels for nymphs in these places equaled zero.
Computed Tomography-Based Body Composition Is Not Consistently Associated with Outcome in Older Patients with Colorectal Cancer
Authors: Looijaard Stéphanie M.L.M. , Meskers Carel G.M. , Slee-Valentijn Monique S. , Bouman Donald E. , Wymenga A.N. Machteld , Klaase Joost M. , Maier Andrea B.
Published: November 2019

Background

Current literature is inconsistent in the associations between computed tomography (CT)-based body composition measures and adverse outcomes in older patients with colorectal cancer (CRC). Moreover, the associations with consecutive treatment modalities have not been studied. This study compared the associations of CT-based body composition measures with surgery- and chemotherapy-related complications and survival in older patients with CRC.

Materials and Methods

A retrospective single-center cohort study was conducted in patients with CRC aged ≥65 years who underwent elective surgery between 2010 and 2014. Gender-specific standardized scores of preoperative CT-based skeletal muscle (SM), muscle density, intermuscular adipose tissue (IMAT), visceral adipose tissue (VAT), subcutaneous adipose tissue, IMAT percentage, SM/VAT, and body mass index (BMI) were tested for their associations with severe postoperative complications, prolonged length of stay (LOS), readmission, and dose-limiting toxicity using logistic regression and 1-year and long-term survival (range 3.7–6.6 years) using Cox regression. Bonferroni correction was applied to account for multiple testing.

Results

The study population consisted of 378 patients with CRC with a median age of 73.4 (interquartile range 69.5–78.4) years. Severe postoperative complications occurred in 13.0%, and 39.4% of patients died during follow-up. Dose-limiting toxicity occurred in 77.4% of patients receiving chemotherapy (n = 53). SM, muscle density, VAT, SM/VAT, and BMI were associated with surgery-related complications, and muscle density, IMAT, IMAT percentage, and SM/VAT were associated with long-term survival. After Bonferroni correction, no CT-based body composition measure was significantly associated with adverse outcomes. Higher BMI was associated with prolonged LOS.

Conclusion

The associations between CT-based body composition measures and adverse outcomes of consecutive treatment modalities in older patients with CRC were not consistent or statistically significant.
On Determinability of a Quotient Divisible Abelian Group of Rank 1 by Its Automorphism Group
Authors: Vildanov Vadim K. , Timoshenko Egor A.
Published: November 2019

A criterion for determinability of a quotient divisible Abelian group of rank 1 by its automorphism group in the class of quotient divisible Abelian groups of rank 1 is considered in the paper
On Domains of Convergence of Multidimensional Lacunary Series
Authors: Tuychiev Taxir T.
Published: November 2019

This paper is devoted to multidimensional analogues of the Fabry and P˙olya theorems on lacunary series. Domains of convergence of lacunary Hartogs series and series in homogeneous polynomials are studied in this paper. Analogues of the Fabry and P˙olya theorems for such series are given and domains of convergence of these series are described. Results of the work develop well-known result of J. Siciak on the domain of convergence of the lacunary series with respect to homogeneous polynomials
Experimental study of the anticonvulsant and psychotropic activities of pufemid, pyrathidine, and compound N3212 as compared with reference anti-epileptic drugs
Authors: Paronikyan R. G. , Avagyan M. N. , Harutyunyan A. A. , Avakyan G. G. , Litvinova S. A. , Voronina T. A.
Published: November 2019

Aim: to study the anticonvulsant and psychotropic activities and side effects of pufemid, pyrathidine and compound N3012 developed at the Institute of Fine Organic Chemistry of the National Academy of Sciences.

Materials and methods. Anticonvulsant activities were tested using the following models of experimental seizures: maximum electric shock, corazol, camphor, thiosemicarbazide, picrotoxin, strychnine, amigdala-kindling convulsions. The psychotropic activities of the tested compounds were investigated using the “elevated plus maze”, “electroshock retrograde amnesia”, and the “open field” models. The neurotoxicity of the compounds was assessed by the level of impaired motor coordination in the “rotating rod” test and in the “grid climbing” test.

Results. Pufemid, pyrathidine, and compound N3212 demonstrated high anticonvulsant activity that was superior to the reference antiepileptic drugs; in addition, the tested compounds had low toxicity and high indicators of therapeutic and protective effects. Pufemid, pyrathidine and compound N3212 showed psychotropic activities: e. g., compound N3212 had anxiolytic and nootropic effects.

Conclusion. The tested compounds – pufemid, pyrathidine and compound N3212 – are highly efficient and low-toxic substances and are, therefore, promising for further preclinical and clinical studies as anti-epileptic drugs with psychotropic activities.
Causes of nosogenic mental disorders in patients with epilepsy
Authors: Kissin M. Ya. , Selyutina E. V.
Published: November 2019

The aim of the article is to review domestic and international reports on the causes of nosogenic mental disorders in patients with epilepsy. Classification of nosogenic mental disorders according to the type of patient’s reaction to the disease is presented. The main causes of nosogenic mental disorders in epilepsy are identified; those are social maladaptation associated with the diagnosis, stigmatization and self-stigmatization as well as the presence of epileptic seizures.
CRIMINOLOGICAL TENDENCIES OF YOUTH CRIME IN LATVIA
Authors: Kipāne Aldona
Published: November 2019

In the age of risk society, the word “crime” is gaining more and more importance. Today’s rapid economic development, dynamic and rather controversial technological processes, which describe the current global environment, call for a more active response to crime as one of the top priorities. In recent years, criminal offences committed by young people, especially minors, are a priority issue for law enforcement authorities, society and the state. The term “youth crime” in criminology has been introduced relatively recently. This topic has been little studied in Latvia. The paper provides an insight into the criminological scope of youth crime. The author would like to launch a discussion on the criminological study prospect of youth crime in Latvia.The aim of the paper is to describe the phenomenon of youth crime by analysing the theoretical and practical aspects. The topicality of the study of the youth crimes’ criminological aspect is determined by the prevalence of this type of crime and the problems in identifying and prevention of it. Such tasks of the study are defined: to describe the criminological content of youth crime and to provide the criminological classification of a subject; to analyse its causes and circumstances contributing to it; to discover the content of criminological prevention. The study is based on the opinions and conclusions of scientists and different documents. Several methods of general scientific research and specific methods are used in the paper: monographic and constructive approaches, logical interpretation, statistical methods and the method of legal norms’ interpretation.The author concludes that youth crime is a complex, dynamic criminological phenomenon with certain regularities, which determine its formation and existence. The author acknowledges that criminological importance is got by early prevention measures, especially for young people whose behaviour manifests itself in a criminal inclination or takes place in a hostile or criminal environment.
THE LEGAL NATURE OF CRIMES IN THE SPHERE OF TERRORISM AND INTERNATIONAL LEGAL INSTRUMENTS TO COMBAT THEM
Authors: Rybak Siarhei
Published: November 2019

The paper deals with the issues of combating terrorism. The authors draw a distinction between the concepts of “international crime” and “crime of an international character”. Particular attention is paid to the lack of a universal definition of the category of “terrorism’s” problem and its reasons. A new vision of the solution to the problem mentioned above has been offered. The paper also analyzes the international regulatory legal acts regulating the struggle against terrorism and their impact on the formation of national legislation in the designated area.
TOPICAL QUESTIONS OF THE PROSECUTION IN LATVIAN CRIMINAL PROCEDURE IN COURT
Authors: Sumbarova Marina
Published: November 2019

One of the institutions of criminal procedural law, which was subjected to change along with others, is the institution of prosecution in criminal procedure of Latvia. The judge, legally and reasonably makes a decision on charges of the criminal procedure for the assignment achievement of the criminal procedure, the person directing process. For this purpose, it is important to evaluate proofs objectively in a criminal case and make the correct decision to prosecute a person. The study of issues, related to the prosecution in judicial criminal procedure is determined in the paper from the point of view of Latvia’s and other scientists. Consideration of theoretical and practical provisions on the research topic allowed implementing individual conclusions and suggestions related to the accusation in judicial criminal procedure of Latvia that definitely will contribute to further improvement of the Criminal Procedural Law of Latvia
THE COMPREHENSION OF OVERCOMING AND NEUTRALIZING THE COUNTERACTION TO THE INVESTIGATION OF CRIMES IN CRIMINALISTICS
Authors: Verenich Igor
Published: November 2019

The paper covers the issues of forming and developing theoretical concepts of overcoming and neutralizing the counteraction to the investigation of crimes.
Association of Carcinoembryonic Antigen with Mortality in an Insurance Applicant Population
Authors: Rigatti Steven J , Stout Robert
Published: November 2019

Objectives.— To quantify the mortality risks associated with elevated levels of carcinoembryonic antigen (CEA).

Background.— Carcinoembryonic antigen is cell surface glycoprotein and has been associated with the presence of high grade or metastatic cancers of the colon as well as other malignant and non-malignant disease. Prior publications have demonstrated the utility of CEA levels in the determination of mortality risk in life insurance applicants. The aim of this paper is to further characterize this risk with a larger set of data containing additional person-years of follow-up, more outcomes, and additional variables potentially associated with occult malignancy.

Methods.— By use of the Social Security Death Index, mortality was examined in 321,574 insurance applicants age 50 years and older, who submitted blood samples to Clinical Reference Laboratories for testing including CEA. Results were stratified by age group and by CEA level (<5 ng/mL, 5 to 9.9 ng/mL, 10+ ng/mL), though other thresholds were tested. Mortality comparisons were carried out using Cox models and tabular methods with the 2015 smoker-distinct Valuation Basic Tables as a comparator.

Results.— Relative mortality is increased at CEA levels above 4.0 ng/mL in both smokers and non-smokers. This association is persistent in Cox models when albumin, BMI and cholesterol are included as covariates. The strongest association with mortality risk occurred in the first 3-4 durations. The 3-year cumulative mortality ratio when using the 2015 VBT as baseline was 6.51 when comparing the group with CEA levels of 10+ ng/mL, compared to those with levels below 5.0 ng/mL.

Conclusion.— This study shows that CEA is strongly associated with the risk of early excess mortality in life insurance applicants, and this risk appears not to be mitigated by consideration of other markers thought to be associated with occult malignancy.
Ground‐Motion Amplification in Cook Inlet Region, Alaska, from Intermediate‐Depth Earthquakes, Including the 2018 Mw 7.1 Anchorage Earthquake
Authors: Moschetti Morgan P. , Thompson Eric M. , Rekoske John , Hearne Michael G. , Powers Peter M. , McNamara Daniel E. , Tape Carl
Published: November 2019

We measure pseudospectral and peak ground motions from 44 intermediate‐depth Mw≥4.9 earthquakes in the Cook Inlet region of southern Alaska, including those from the 2018 Mw 7.1 earthquake near Anchorage, to identify regional amplification features (0.1–5  s period). Ground‐motion residuals are computed with respect to an empirical ground‐motion model for intraslab subduction earthquakes, and we compute bias, between‐, and within‐event terms through a linear mixed‐effects regression. Between‐event residuals are analyzed to assess the relative source characteristics of the Cook Inlet earthquakes and suggest a difference in the scaling of the source with depth, relative to global observations. The within‐event residuals are analyzed to investigate regional amplification, and various spatial patterns manifest, including correlations of amplification with depth of the Cook Inlet basin and varying amplifications east and west of the center of the basin. Three earthquake clusters are analyzed separately and indicate spatial amplification patterns that depend on source location and exhibit variations in the depth scaling of long‐period basin amplification. The observations inform future seismic hazard modeling efforts in the Cook Inlet region. More broadly, they suggest a greater complexity of basin and regional amplification than is currently used in seismic hazard analyses.
Using Component Ratios to Detect Metadata and Instrument Problems of Seismic Stations: Examples from 18 Yr of GEOSCOPE Data
Authors: Pedersen Helle A. , Leroy Nicolas , Zigone Dimitri , Vallée Martin , Ringler Adam T. , Wilson David C.
Published: November 2019

Replacement or deterioration of seismic instruments and the evolution of the installation conditions and sites can alter the seismic signal in very subtle ways; therefore, it is notoriously difficult to monitor the signal quality of permanent seismic stations. We present a simple way to characterize and monitor signal quality, using energy ratios between each pair of the three components, as a complement to existing methods. To calculate stable daily energy ratios over a large frequency range (0.01–5 Hz), we use the daily median energy ratio over all 5 min windows within the day. The method is applied to all GEOSCOPE stations, for continuous BH channel data collected since 2001. We show applications to identify past gain problems (stations ROCAM and CRZF), to provide feedback after field interventions at remote sites (Antarctic station DRV), and to shed light on complex instrument problems (stations ECH and KIP). Our results show that component energy ratios have excellent time resolution and that they are visually simple for identification of problems. They can be used both for ongoing continuous monitoring of the signal quality, or as a tool to identify past problems. The Python code to produce the results in this work and the Python code for daily monitoring used by GEOSCOPE are available (see Data and Resources).
The Sedimentary Record of the 2018 Anchorage Earthquake in Eklutna Lake, Alaska: Calibrating the Lacustrine Seismograph
Authors: Van Daele Maarten , Haeussler Peter J. , Witter Robert C. , Praet Nore , De Batist Marc
Published: November 2019

The 30 November 2018 Mw 7.1 Anchorage earthquake caused modified Mercalli intensities of V¼ to V½ at Eklutna Lake (south central Alaska). A few hours after the earthquake, a “dirt streak” was observed on the lake surface, followed by a peak in sediment turbidity values (∼80 times normal) at a drinking water facility, which receives water from the lake through a pipe. These observations hint toward turbidity currents triggered by the earthquake in Eklutna Lake. Here, we study 32 short sediment cores retrieved from across Eklutna Lake and observe a millimeter‐to‐centimeter scale turbidite that can be confidently attributed to the 2018 earthquake in all coring locations. X‐ray computed tomography, grain‐size, and color‐spectral analyses of the turbidite show that it shares physical characteristics with the turbidite generated by the 1964 Mw 9.2 Great Alaska earthquake, while it is considerably different from turbidites caused by historical floods. The 2018 turbidite reaches its largest thickness in the inflow‐proximal basin, but when compared to the 1964 turbidite and thereby canceling out local site effects, it is relatively thick in the inflow‐distal sub‐basin. The latter was exposed to stronger shaking during the 2018 earthquake, and this relative thickness trend may therefore be attributed to shaking intensity and gives an indication of the location of the earthquake epicenter relative to the basin axis. Furthermore, in contrast to the 1964 turbidite, which was sourced from both deltas and hemipelagic slopes, the 2018 turbidite was sourced from deltas only, as evidenced by its distribution. These results confirm that while it is generally accepted that shaking intensities of ≥VI are needed to trigger turbidity currents from hemipelagic slopes, intensities as low as V¼ can be sufficient to trigger turbidity currents from deltaic slopes. Our results show that proglacial lakes can sensitively record differences in shaking intensity and that investigating deposits from recent earthquakes is crucial to calibrate the lacustrine seismograph.
Therapy of patients with the high risk of arterial hypertension with the use of telmisartan
Authors: Nikitin A. V. , Vasilieva L. V. , Gosteva E. V. , Starodubtseva I. A. , Latisheva M. N.
Published: November 2019

Aim. The study assesses the effects of therapy based on the use of telmisartan in patients with arterial hypertension and stable angina on the clinical and functional indicators of the cardiovascularvascular system. Material and methods. 52 patients with a combination of arterial hypertension (AH) I and II stages and coronary artery disease II with the mean age 63.5 ± 5.4 years (79% males and 21% of females) were enrolled in the trial. The duration of AH and CAD were 17.5±3.8 and 12.5±3.1 accordingly. All patients took a daily 80 mg dose of telmisartan. The efficacy of treatment was estimated in 3,6 and 12 months. Results. The use of telmisartan in complex treatment of high-risk patients with AH has led to decreasing blood pressure to the target level, increasing exercise tolerance (walking the distance from 315.5 m to 410.2 m in 6 minutes). 12 months of therapy based on telmisartan showed significant decrease in left hy‑ pertrophy ventricle (LV myocardial mass index on average by 10.4%), a decrease in the total duration of depression ST segment from 9.6±2.9 to 2.7±1.5 mm and a decrease in the depth of depression from 1.5±0.3 mm to 0.3±0.09 mm, with a trend towards decrease in the number of episodes of ST-segment depression, as well as the absence of a significant change in heart rate. After 12 months of en‑ dothelium-dependent vasodilation therapy, the condition of 31 (60%) patients improved, and 18 (35%) patients showed the tendency to improvement. The tests with reactive hyperemia conducted after 12 months of treatment revealed decreased linear velocity of blood flow in the brachial artery on average by 17%. Conclusion. The use of telmisartan in complex therapy improves the quality of life according to the EQ-VAS questionnaire by 25 points after 12 months of therapy, contributes to lowering blood pressure in 96% of patients, reduc‑ ing myocardial hypertrophy, endothelial dysfunction and severity of ischemic manifestations (reducing the need for nitroglycerin intake to an average of 0,5 inhalations, as well as a decrease in the ST segment depression of 40% after 12 months of therapy).
Valoración de servicios ecosistémicos para la identificación de estructuras ecológicas metropolitanas: el caso de Cali, Colombia
Authors: Tabares-Mosquera M. , Zapata-Caldas E. , Buitrago-Bermúdez O.
Published: November 2019

El objetivo de la presente investigación fue valorar –con base en técnicas de análisis espacial y conocimiento experto– la capacidad de las coberturas de la tierra para proporcionar servicios ecosistémicos (SE) en el sistema socioecológico (SSE) “área de influencia metropolitana de Cali”. De esa manera, fue posible identificar la estructura ecológica metropolitana del SSE en mención, para así establecer una línea base a partir de la cual se podrá identificar en el futuro el nivel de conservación o fragmentación de la estructura ecológica metropolitana. La aplicación de la metodología requirió el uso de métodos de investigación mixtos. En este sentido, i) se definió el área del SSE a partir de la combinación de criterios urbano-funcionales y ecológicos-biofísicos; ii) se definieron los criterios para establecer la unidad de análisis y realizar la clasificación de coberturas de la tierra del área definida a escala 1:25.000; y iii) se realizó la valoración de SE a partir de una consulta a expertos pertenecientes a instituciones de carácter académico, administrativo y científico acerca de la capacidad de proporcionar y demandar SE presentes en las coberturas de la tierra que componen el SSE. Se encontró que la estructura ecológica metropolitana está compuesta por diez coberturas de la tierra naturales y seminaturales, las cuales tienen capacidad de proporcionar SE culturales (nivel alto), de regulación (niveles alto y medio) y de aprovisionamiento (nivel bajo). Además, como era de esperar, se validó la percepción de que la zona plana del SSE –la cual concentra las actividades productivas, económicas y de servicios– es claramente la demandante, mientras que las áreas ubicadas en la periferia–i. e. piedemontes y cordilleras Oriental y Occidental– son las proveedoras. Finalmente, los resultados de esta investigación demuestran una vez más que, desde el ángulo académico, hay maneras novedosas para fortalecer los procesos de formulación de lineamientos para la planificación y gestión ambiental de los SSE de carácter metropolitano a partir de la combinación de información espacial y conocimiento experto.
THEORETICAL AND EXPERIMENTAL INVESTIGATION OF CRACK PROPAGATION DIRECTION. PART I
Authors: Dolgikh V. S. , Pulkin A. V. , Mironova E. A. , Peksheva A. A. , Stepanova L. V.
Published: November 2019

In the present paper the crack propagation direction angles on the basis of three diﬀerent fracture criteria are found. The maximum tangential stress criterion, the minimum strain energy density criterion and the deformation criterion are used and analysed. The generalized forms of these criteria have been used. It implies that the crack propagation direction angles are obtained with the Williams series expansion in which the higher order terms are kept. The calculations are performed in Waterloo Maple computer algebra software. The analysis of the crack propagation direction angles show that the inﬂuence of the higher order terms cant be ignored. The angles diﬀer considerably when the higher order terms are taken into account.
ON SOME CLASS OF INTERPOLATION FUNCTORS
Authors: Astashkin S. V.
Published: November 2019

As it is well known, the Gustavsson Peetre construction, using the concept of unconditional convergence in Banach spaces, provides an important class of interpolation functors. In this paper, we deﬁne a new close construction, based on the use of the so-called random unconditional convergence. We ﬁnd necessary and suﬃcient conditions, which being imposed on a generating function give us an interpolation functor deﬁned on the category of Banach couples. It is shown that calculating the latter functor for a couple of Orlicz spaces results in the natural interpolation theorem. Moreover, we obtain conditions that guarantee the coincidence of this functor with the corresponding Gustavsson Peetre functor, as well as with the Calderon Lozanovskii method.
Internal force field in selected proteins
Authors: Ptak-Kaczor Magdalena , Banach Mateusz , Konieczny Leszek , Roterman Irena
Published: November 2019

The fuzzy oil drop model suggests that the tertiary conformation of a protein – particularly a globular one – can be likened to a spherical micelle. During the folding process, hydrophilic residues are exposed on the surface, while hydrophobic residues are retained inside the protein. The resulting hydrophobicity distribution can be mathematically modeled as a 3D Gaussian. The fuzzy oil drop model is strikingly effective in explaining the properties of type II antifreeze proteins and fast-folding proteins, as well as a vast majority of autonomous protein domains. This work aims to determine whether similar mechanisms apply to other types of nonbonding interactions. Our analysis indicates that electrostatic and van der Waals forces do not conform to the Gaussian pattern. The study involves a reference protein (titin) which shows a high agreement between the observed distribution of hydrophobicity and the theoretical (Gaussian) distribution, a selection of amyloid structures derived from the Protein Data Bank, as well as transthyretin – a protein known for its susceptibility to amyloid transformation.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells
Authors: Kawase Atsushi , Inoue Yuta , Hirosoko Miho , Sugihara Yuka , Shimada Hiroaki , Iwaki Masahiro
Published: November 2019

Purpose: The plasma membrane localization and transport activity of multidrug resistance-associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters are governed by transporter-associated proteins. Phosphatidylinositol 4,5-bisphosphate (PIP2) formed by phosphatidylinositol 4-phosphate 5-kinase type 1 (PIP5K1) activates the linker function of radixin for efflux transporters. Radixin is involved in the plasma membrane localization of efflux transporters. We examined whether PIP5K1 could be a target for the modulation of transporter activities in hepatocytes and cancer cells. Methods: The effects of PIP5K1 depletion by siRNA in mouse primary hepatocytes, PANC1 human pancreatic carcinoma cells, and HepG2 human hepatocellular carcinoma cells on the intracellular accumulation of MRP2 and P-gp substrates were examined. Results: PIP5K1A depletion resulted in increased intracellular accumulation of carboxydichlorofluorescein, a MRP2 fluorescent substrate, in mouse primary hepatocytes, PANC1 cells, and HepG2 cells. In PANC1 and HepG2 cells, the transport activities of MRP2 were significantly decreased by PIP5K1C depletion. However, the transport activities of P-gp were unchanged by PIP5K1 depletion. PIP2 levels were unchanged between control and PIP5K1A- or PIP5K1C-depleted HepG2 cells. MRP2 mRNA levels showed few changes in HepG2 cells following PIP5K1A or PIP5K1C depletion. The expression of phosphorylated radixin was decreased by PIP5K1A and PIP5K1C depletion, although total radixin levels were unchanged. Conclusions: These data suggest that PIP5K1A and PIP5K1C could be target proteins for modulating MRP2 function, partly because of the resulting changes of the linker function of radixin.
Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes
Authors: Guo Cen , Brouwer Kim L.R. , Brouwer Kenneth R. , Stewart Paul W , Mosley Caroline
Published: November 2019

PURPOSE: Probe substrates are used routinely to assess transporter function in vitro. Administration of multiple probe substrates together as a “cocktail” in sandwich-cultured human hepatocytes (SCHH) could increase the throughput of transporter function assessment in a physiologically-relevant in vitro system. This study was designed to compare transporter function between cocktail and single agent administration in SCHH. METHODS: Rosuvastatin, digoxin, and metformin were selected as probe substrates of hepatic transporters OATP1B1, OATP1B3, BCRP, P-gp, and OCT1. Total accumulation (Cells+Bile) and biliary excretion index (BEI) values derived from administration of the cocktail were compared to values obtained after administration of single agents in the absence and presence of a model inhibitor, erythromycin estolate. RESULTS: For rosuvastatin and metformin accumulation, the ratio of means [90% confidence interval (CI)] for cocktail to single agent administration was 100% [94%, 106%] and 90% [82%, 99%], respectively. Therefore, the cocktail and single-agent mode of administration were deemed equivalent per standard equivalence criterion of 80-120% for rosuvastatin and metformin accumulation, but not for digoxin accumulation (77% [62%, 92%]). The ratio of means [90% CI] for rosuvastatin BEI values between the two administration modes (105% [97%, 114%]) also was deemed equivalent. The ratio for digoxin BEI values between the two administration modes was 99% [78%, 120%]. In the presence of erythromycin estolate, the two administration modes were deemed equivalent for evaluation of rosuvastatin, digoxin, and metformin accumulation; the ratio of means [90% CI] was 104% [94%, 115%], 94% [82%, 105%], and 100% [88%, 111%], respectively. However, rosuvastatin and digoxin BEI values were low and quite variable in the presence of the inhibitor, so the BEI results were inconclusive. CONCLUSIONS: These data suggest that rosuvastatin and metformin can be administered as a cocktail to evaluate the function of OATP1B1, OATP1B3, BCRP, and OCT1 in SCHH, and that digoxin may not be an ideal component of such a cocktail.
REPERCUSSÃO DA RELAÇÃO PROFESSOR-ALUNO NA FORMAÇÃO DE GRADUANDOS EM ENFERMAGEM
Authors: De Mattos Larissa Merino , Ramos Aline Marcelino , Barlem Edison Luiz Devos , Gama Bárbara Da silva , Minasi Alex Sandra Ávila , Amorim Caroline Bettanzos
Published: November 2019

Objetivo: analisar a repercussão da relação professor-aluno na formação de graduandos em enfermagem. Método: estudo qualitativo, exploratório-descritivo, realizado com 27 estudantes do curso de graduação em enfermagem de uma universidade pública do Sul do Brasil. A coleta de dados ocorreu no mês de julho de 2017. Os dados foram analisados segundo a análise textual discursiva. Resultados: da análise dos dados, emergiram três categorias: “Barreiras na relação professor-aluno”, “Facilitadores da relação professor-aluno” e “Ética nas relações professor-aluno”.
 Conclusão: a repercussão da relação professor-aluno na formação de graduandos em enfermagem perpassa aspectos que contemplam não apenas o currículo acadêmico, mas também aspectos relacionais que determinam a forma de ser e agir dos futuros profissionais.

Descritores: Enfermagem. Educação em Enfermagem. Estudantes de Enfermagem. Docentes de Enfermagem. Ética.
CUIDADOS DE ENFERMAGEM PRESTADOS À CRIANÇA HOSPITALIZADA COM DOR ONCOLÓGICA CRÔNICA: PERCEPÇÕES DOS PROFISSIONAIS DE SAÚDE
Authors: Silva Thiago Privado da , Silva Laura Johanson da , Silva Italo Rodolfo , Cardoso Juliana Maria Rego Maciel , Leite Joséte Luzia
Published: November 2019

Objetivo: compreender a percepção dos profissionais de saúde sobre os cuidados de enfermagem prestados à criança hospitalizada com dor oncológica crônica. Método: abordagem qualitativa, ancorada nos referenciais teórico e metodológico, respectivamente, da Teoria da Complexidade e da Teoria Fundamentada em Dados. Os dados foram coletados por meio de entrevista semiestruturada e observação não participante. Participaram da pesquisa 21 profissionais de saúde. Resultados: os profissionais de saúde qualificaram como boa a assistência de enfermagem oferecida à criança com dor oncológica crônica. No entanto, foi revelada a necessidade de avanços: nos aspectos estruturais da unidade e organizacionais do cuidado, na abordagem ao familiar da criança, na abordagem à criança em precaução de contato e valorização profissional. Conclusão: o cuidado de enfermagem prestado à criança com dor oncológica crônica apresentava-se como um desafio, seja pelas necessidades de melhorias apontadas, seja por questões gerenciais e de liderança.

Descritores: Enfermagem Pediátrica. Cuidados de Enfermagem. Dor do Câncer. Hospitais. Pessoal de Saúde. Criança.
ABOUT DYNAMICS OF THE GEOPOLITICAL POSITION OF THE NORTH-EAST OF RUSSIA IN THE 17-TH-21-ST CENTURIES
Authors: V. G. Shvedov , M. T. Romanov
Published: November 2019

Purpose: In the article, the changes in the geopolitical situation on the North-East for four preceding, partial centuries are considered.

Methodology: Up to the inclusion in the structure of Russia, this extensive region (2.3 million km2) with the considerable natural-resources potential has actually existed out of the world geopolitical processes, basically, because of the extremeness of the natural climatic conditions, remoteness from the centers of world civilization and limited technical and technological capabilities in those times.

Result: The different stages in the state of the geopolitical position of the region in prior centuries are identified and their repeatedly and multidirectional varying characteristics during the period in question are reported. It is also emphasized that the measures attempted by Russia for strengthening of the geopolitical position on the North-East gave rise abroad to the negative response consonant with the current ones practically at all considered stages. The current stage is considered as a period of the drastically varying external geopolitical conditions and increased technical capabilities when the geopolitical significance of the North-East for Russia increases by a factor of many times.

Applications: This research can be used for universities, teachers, and students.

Novelty/Originality: In this research, the model of About Dynamics of the Geopolitical Position of the North-East of Russia in the 17-th-21-st Centuries is presented in a comprehensive and complete manner.
NATURE OF LEGAL BEHAVIOR: THE CONCEPTS OF DEFINITION AND THEIR EVOLUTION
Authors: N. Oleinykov Sergii , S. Shestopal Sergey , N. Babenko Vasily , P. Rabets Anna , V. Burova Elena
Published: November 2019

Purpose: The purpose of the study is determining nature of legal behavior: the concepts of definition and their evolution

Methodology: This is intellectual research and we used here historical methods for analyzing.

Result: The genesis of the concept of legal behavior implies a link between research and the praxeological dimension of the legal system in which the legal personality is a central element.

Applications: This research can be used for universities, teachers, and students.

Novelty/Originality: In this research, the model of nature of legal behavior: the concepts of definition and their evolution are presented in a comprehensive and complete manner.