bluuebunny/crossref_metadata_2025 huggingface dataset:
System Archetypes Underlying Formal-Informal Urban Water Supply Dynamics
Authors: Bano Rakhshinda , Khiadani Mehdi , Nyam Yong Sebastian
Published: September 2022

Contrary to developed countries, developing countries have been observed to have an increased reliance on a diversity of water supply options to meet their daily demands, where formal supply systems are incapable of fulfilling the daily needs of consumers. In filling a demand-supply gap, informal supply systems are increasingly being associated with issues of long-term sustainability, higher consumer cost, and inequity. Emerging formal-informal dynamics in developing countries require a thorough understanding of complex human-water interactions for policy direction, in order to best support the advancement of urban water sustainability. Accordingly, system archetypes offer a platform to explain the behaviors of complex systems. This paper identifies common system archetypes that define urban waterscapes in the developing world. In this way, Causal Loop Diagrams (CLDs) are used to present relationships and identify common archetypes that define the complexity of urban water supply systems in Hyderabad, Pakistan. These archetypes include ‘fixes that fail’, ‘shifting the burden’, ‘limits to growth/success’ and ‘growth and underinvestment’. These archetypes demonstrate that increases in formal infrastructure capacity and the number of informal suppliers to increase supply reliability are symptomatic solutions, restrained by financial and technical resources, and thus have unintended consequences. Further, a number of policy instruments are discussed as leverage points to achieve financial sustainability of formal systems. This paper emphasizes the need of a policy framework for informal supply system in national and regional water policies to ensure its service reliability as a short to medium term solution.
Stereotactic body radiation therapy for metastatic lung metastases
Authors: Kimura Tomoki , Fujiwara Toshiki , Kameoka Tsubasa , Adachi Yoshinori , Kariya Shinji
Published: September 2022

Although systemic therapy is standard management for patients with metastatic disease, several recent reports have indicated that an addition of local therapies including stereotactic body radiation therapy (SBRT) for patients with oligometastatic disease (OMD) could improve survival. The lung is the most common site of distant metastasis from many solid tumors, and the strategy of SBRT, such as dose-fraction schedules, timing, etc., would be different depending on the type of primary tumor, location, and patterns of OMD. This review describes the role of SBRT with curative-intent for patients with pulmonary OMD for each of these variables. First, differences according to the type of primary tumor, for which many studies suggest that SBRT-mediated local control (LC) for patients with pulmonary OMD from colorectal cancer (CRC) is less successful than for those from non-CRC tumors. In addition, higher dose-fraction schedules seemed to correlate with higher LC; hence, different SBRT treatment strategies may be needed for patients with pulmonary OMD from CRC relative to other tumors. Second, differences according to location, where the safety of SBRT for peripheral pulmonary tumors has been relatively well established, but safety for central pulmonary tumors including pulmonary OMD is still considered controversial. To determine the optimal dose-fraction schedules, further data from prospective studies are still needed. Third, differences according to the patterns of OMD, the number of metastases and the timing of SBRT whereby 1–5 lesions in most patients and patients with synchronous or metachronous OMD are considered good candidates for SBRT. We conclude that there are still several problems in defining suitable indications for local therapy including SBRT, and that further prospective studies are required to resolve these issues.
Fictional Film in Engineering Ethics Education: With Miyazaki’s The Wind Rises as Exemplar
Authors: Hitt Sarah Jayne , Lennerfors Thomas Taro
Published: September 2022

This paper aims to call attention to the potential of using film in engineering ethics education, which has not been thoroughly discussed as a pedagogical method in this field. A review of current approaches to teaching engineering ethics reveals that there are both learning outcomes that need more attention as well as additional pedagogical methods that could be adopted. Scholarship on teaching with film indicates that film can produce ethical experiences that go beyond those produced by both conventional methods of teaching engineering ethics and more arts-based methods such as fiction, as well as connect ethics learning outcomes and issues to the lifeworld of a person. The paper further illustrates the potential of using Miyazaki Hayao’s film The Wind Rises for highlighting a range of ethical issues pertaining to engineering. It also discusses the important role educators play in how film can be used effectively in the classroom. Synthesizing a range of sources from film theory to the use of film in business and medical education, the paper makes the case for using film in engineering ethics education and calls for more research on the use of this method.
Simultaneous Determination of the Saponification Value, Acid Value, Ester Value, and Iodine Value in Commercially Available Red Fruit Oil (Pandanus conoideus, Lam.) Using 1H qNMR Spectroscopy
Authors: Triyasmono Liling , Schollmayer Curd , Schmitz Jens , Hovah Emilie , Lombo Cristian , Schmidt Sebastian , Holzgrabe Ulrike
Published: September 2022

Red fruit oil (RFO) can be extracted from fruits of Pandanus conoideus, Lam., an endogenous plant of Papua, Indonesia. It is a commonly used essential original traditional medicine. By applying a newly developed quantitative 1H NMR (qNMR) spectroscopy method for quality assessment, a simultaneous determination of the saponification value (SV), acid value (AV), ester value (EV), and iodine value (IV) in RFO was possible. Dimethyl sulfone (DMSO2) was used as an internal standard. Optimization of NMR parameters, such as NMR pulse sequence, relaxation delay time, and receiver gain, finally established the 1H NMR-based quantification approach. Diagnostic signals of the internal standard at δ = 2.98 ppm, SV at δ = 2.37–2.20 ppm, AV at δ = 2.27–2.20 ppm, EV at δ = 2.37–2.27 ppm, and IV at δ = 5.37–5.27 ppm, respectively, were used for quantitative analysis. The method was validated concerning linearity (R2 = 0.999), precision (less than 0.83%), and repeatability in the range 99.17–101.17%. Furthermore, this method was successfully applied to crude RFO, crude RFO with palmitic and oleic acid addition, and nine commercial products. The qNMR results for the respective fat values are in accordance with the results of standard methods, as can be seen from the F- and t-test (< 1.65 and < 1.66, respectively). The fundamental advantages of qNMR, such as its rapidity and simplicity, make it a feasible and existing alternative to titration for the quality control of RFO.
Knowing Other Minds: A Scorekeeping Model
Authors: Lo Presti Patrizio
Published: September 2022

The prepositional ‘in’ and possessive pronouns, e.g., ‘my’ and ‘mine,’ in the context of attributions of mental states, such as “in my mind” or “in your mind,” threaten to confuse attempts to account for knowledge of other minds. This paper distinguishes proper from improper uses of such expressions. I will argue that proper use of the prepositional ‘in’ and possessive pronouns in the context of mental state attributions presupposes capacities to properly track and attribute what are really, in a sense to be specified, intersubjectively articulated and inferentially interrelated normative statuses. What we call “mental states” or “minds,” in as far as primarily cognitive states such as beliefs are concerned, are intersubjectively constituted. As opposed to being inner and private, something we must learn to intersubjectively discover, minds and mental states are intersubjectively articulated and we learn to attribute them as inner and private. A scorekeeping-model is used to illustrate how the privacy of mind presupposes intersubjectivity. Using that model, I argue that the traditional problem of knowing other minds can be re-framed as a problem of learning how to pursue intersubjective practices of acknowledging, attributing and undertaking mental states.
Study on the influence of mechanical characteristics of multi-rhythm inter-salt shale oil on fracture propagation in Qianjiang formation, China
Authors: Zeng Yijin , Guo Yintong , Zhang Xu , Ying Qiqi , Chang Xin
Published: September 2022

There are many inter-salt rhythmic shale reservoirs in Qianjiang sag, and the mineral composition content with different rhythms is different. The thin interbedding characteristics of inter-salt shale oil reservoirs bring technical challenges to hydraulic fracturing. Taking one shale oil well in Qianjiang depression as an example, the mechanical properties and interface characteristics of rock under temperature and confining pressure are analyzed. The physical simulation test of fracture propagation under different fracturing fluid is completed, and the effects of four different factors on fracture propagation are analyzed by numerical analysis method. The results show that the mechanical characteristic and failure modes with different rhythms are obvious differences. Under uniaxial and triaxial compression, glauberite mudstone and shale have high strength, and salt rock shows obvious plastic deformation characteristics. The interbedded rock has clear interface characteristics. The cohesion of glauberite mudstone and shale bedding surface obtained from direct shear test is 0.60 MPa and 0.99 MPa. The fracture morphology of inter-salt shale is mainly affected by the development degree of rock bedding. The mechanical parameters, in situ stress difference, and the displacement have an important impact on the longitudinal propagation of fracturing fractures. The width and height of fracture propagation decrease, with the increase in the minimum horizontal principal stress in the salt layer, and the width of fracture in shale increases. The crack height decreases with the increase in tensile strength of the interlayer. With the increase in fracturing fluid injection rate from 3.0 to 7.0 ml/min, the propagation height of hydraulic fractures and the width of fractures in shale increase significantly. The research results can apply to understanding the mechanism of hydraulic fracture propagation in inter-salt shale formation.
Structural assessment of the pedestrian bridge accessing Civita di Bagnoregio, Italy
Authors: Buffarini Giacomo , Clemente Paolo , Giovinazzi Sonia , Ormando Chiara , Scafati Federico
Published: September 2022

The paper presents the results of the vibration tests carried out on the pedestrian bridge accessing Civita di Bagnoregio, Italy. The structure was in bad health condition. The external beams were damaged due to deterioration exacerbated by the combined actions of rain and wind. The circular piers were also damaged with several cracks where the concrete cover was spliced and the reinforcement bars were exposed. The analysis presented in the paper focuses on the highest five piers, which seemed to show an irregular behavior during a preliminary experimental campaign. The results of the experimental campaign presented in this paper showed that the structural behavior of the bridge was qualitatively similar to the expected one. The reduced stiffness, due to the observed widespread damage state, amplified the vibrations uniformly along the structure. The Italian Guidelines for the risk and safety assessment of bridges and viaducts, issued in 2020, have been applied and tested in this study and the results are presented in the paper.
Presence of regulatory T-cells in endometrial cancer predicts poorer overall survival and promotes progression of tumor cells
Authors: Kolben Thomas , Mannewitz Mareike , Perleberg Carolin , Schnell Konstantin , Anz David , Hahn Laura , Meister Sarah , Schmoeckel Elisa , Burges Alexander , Czogalla Bastian , Hester Anna , Mahner Sven , Kessler Mirjana , Jeschke Udo , Corradini Stefanie , Trillsch Fabian , Beyer Susanne
Published: September 2022

Purpose

Endometrial cancer (EC) is one of the most common gynaecologic malignancies. Tumor infiltrating regulatory T-cells (Treg) have been reported to have a prognostic impact in many malignancies. Immunotherapeutic strategies are gaining interest for advanced and recurrent EC cases, where treatment options are rare. Our study was aimed at determining the value of Treg in EC progression.

Methods

EC specimens from 275 patients and 28 controls were screened immunohistochemically for the presence of Treg represented by FoxP3. Correlations with clinicopathological and survival parameters were performed. Functional assays were performed using EC cell lines Ishikawa + and RL95-2 after co-culturing with isolated CD4 + CD25 + CD127dim Treg. To assess the influence of EC on the composition of peripheral blood mononuclear cells (PBMC), flow cytometric analyses were performed.

Results

We found that an increased infiltration of Treg was associated with high grades and a reduced overall survival. Treg were almost absent in endometrium tissues from healthy control patients. Co-culture of tumor cells with CD4 + CD25 + CD127dim Treg led to functional changes: enhanced invasion, migration and viability indicated that increased levels of Treg in the tumor microenvironment may promote tumor growth. Furthermore, we found that the presence of EC cells led to phenotypic changes in PBMC, showing significantly increased levels of CD25 and FoxP3.

Conclusion

Our results indicate that the presence of Treg in the EC tumor environment is associated with a poorer outcome. A remarkable impact of Treg on tumor cell behaviour and vice versa of tumor cells on PBMC subpopulations support this notion mechanistically. Our findings provide a basis for focusing on Treg as potential future therapeutic targets in EC.
Teachers’ Perspectives on Improving Online Seminars in Pharmacology: A Quantitative and Qualitative Study on Lessons Learned During the COVID-19 Pandemic
Authors: Aydogdu Ozgu , Winder Michael
Published: September 2022

The aim of this study is to evaluate teachers' perceptions of online seminars during COVID-19 pandemic to improve future courses in pharmacology. The study was performed as a questionnaire survey. A questionnaire that included 11 questions was used. A total of 14 online seminar teachers, of which 9 were senior teachers and 5 were PhD students, filled out the questionnaire. PhD students’ and senior teachers’ answers to questions 1–5 were compared statistically. The results of questions 6–10 were analysed qualitatively through thematic content analysis. There were no significant differences between senior teachers and PhD students in regard to the scores given to questions 1–5 in the questionnaire. Most (65%) teachers scored the online seminars lower than in person seminars. Interaction, communication, and group dynamics were mostly perceived to be less effective at online seminars compared to in person seminars. The main advantages of online seminars were time saving and flexibility. The main disadvantages of online seminars were reduced student interest, risk of monologue discussion and poorer communication without body language. Most teachers experienced minor technical problems with internet connection and sound quality. The teachers mentioned that better group dynamics, smaller groups, better chat functionality and clearer guidelines could help to improve online seminars. As an alternative to online seminars, blended-learning could be used. This way, one could appreciate both the richness of interactions in a face-to-face environment as well as the flexibility and convenience of online learning. Further studies comparing blended-learning and online teaching at seminars are needed to investigate this issue.
Visual Data Analysis with Task-Based Recommendations
Authors: Shen Leixian , Shen Enya , Tai Zhiwei , Xu Yihao , Dong Jiaxiang , Wang Jianmin
Published: September 2022

General visualization recommendation systems typically make design decisions for the dataset automatically. However, most of them can only prune meaningless visualizations but fail to recommend targeted results. This paper contributes TaskVis, a task-oriented visualization recommendation system that allows users to select their tasks precisely on the interface. We first summarize a task base with 18 classical analytic tasks by a survey both in academia and industry. On this basis, we maintain a rule base, which extends empirical wisdom with our targeted modeling of the analytic tasks. Then, our rule-based approach enumerates all the candidate visualizations through answer set programming. After that, the generated charts can be ranked by four ranking schemes. Furthermore, we introduce a task-based combination recommendation strategy, leveraging a set of visualizations to give a brief view of the dataset collaboratively. Finally, we evaluate TaskVis through a series of use cases and a user study.
Wissenschaftskommunikation als Kontaktzone und Kontaktszene
Authors: Griem Julika
Published: September 2022

Die Forschung zu Wissenschaftskommunikation wird von konfligierenden normativen Prämissen, unreflektierten Modellen und politischen Maßgaben mitbestimmt. Der Beitrag erörtert das Potenzial vom M.L. Pratts Begriff der »Kontaktzone«, um der Kontingenz und Konfliktträchtigkeit des kommunikativen Grenzverkehrs zwischen Wissenschaft und Gesellschaft besser gerecht werden zu können. Im Zentrum stehen sowohl verräumlichende Konzeptbegriffe als auch reale Schauplätze von Wissenschaftskommunikation in verschiedenen Inszenierungs- und Erzählformaten wie z.B. der BerlinerFalling Walls-Konferenz. Als zentrales Problem zwischen Programmen und Praxis, ›talk‹ und ›action‹ der Wissenschaftskommunikation markiert der Beitrag mit Helen Wilson die Paradoxien organisierter Begegnungen: Will man Wissenschaftskommunikation im Zeichen von Dialog und Partizipation institutionalisieren, dürfen Störungen und Überraschungen nicht einem Ideal von plan- und kontrollierbarer Kommunikation untergeordnet werden. Störungen sind vielmehr als konstitutiver Bestandteil auch der Wissenschaftskommunikation zu denken; und ihre materiellen Orte und diskursiven Räume, ihre Gelegenheiten und Rituale dürfen sich daher nicht vorschnell gegen Unvorhergesehenes abschließen.
NUA and ESD4 negatively regulate ABA signaling during seed germination
Authors: Cui Xiaona , Lv Mengyang , Cao Yuanyuan , Li Ziwen , Liu Yan , Ren Zhenzhen , Zhang Hairong
Published: September 2022

The phytohormone abscisic acid (ABA) plays important roles in plant growth, development and adaptative responses to abiotic stresses. SNF1-related protein kinase 2s (SnRK2) are key components that activate the ABA core signaling pathway. NUCLEAR PORE ANCHOR (NUA) is a component of the nuclear pore complex (NPC) that involves in deSUMOylation through physically interacting with the EARLY IN SHORT DAYS 4 (ESD4) SUMO protease. However, it is not clear how NUA functions with SnRK2 and ESD4 to regulate ABA signaling. In our study, we found that nua loss-of-function mutants exhibited pleiotropic ABA-hypersensitive phenotype. We also found that ABA-responsive genes remarkably up-regulated in nua by exogenous ABA. The nua snrk2.2 snrk2.3 triple mutant and nua abi5 double mutant partially rescued the ABA-hypersensitive phenotype of nua, thereby suggesting that NUA is epistatic to SnRK2s. Additionally, we observed that esd4-3 mutant was also ABA-hypersensitive. NUA and ESD4 were further demonstrated to physically interact with SnRK2s and negatively regulate ABA signaling by reducing SnRK2s stability. Taken together, our findings uncover a new regulatory mechanism that can modulate ABA signaling.
Mapping neuromodulatory systems in Parkinson’s disease: lessons learned beyond dopamine
Authors: Ye Zheng
Published: September 2022

Parkinson’s disease (PD) is the second most common neurodegenerative disease with mixed motor and non-motor symptoms. Dopaminergic drugs remain the mainstay of therapy for PD. However, some motor symptoms (e.g., gait problems) and a broad range of non-motor symptoms (e.g., cognitive impairment and depression) are often unresponsive to dopaminergic drugs. It is because the pathology of PD is not limited to the loss of midbrain dopamine neurons. Recent in vivo human brain imaging studies have provided novel insights into the dysfunction of multiple non-dopaminergic systems in PD. I review positron emission tomography, single photon emission computed tomography, neuromelanin-sensitive magnetic resonance imaging, and functional magnetic resonance imaging studies demonstrating the parallel alteration of noradrenergic, serotonergic, and cholinergic systems in PD. These studies shed light on the relationship between neuromodulators and vulnerable cognitive, affective, and motor functions. I finally discuss open questions in the field. More human pharmacological imaging studies are needed to reach a mechanistic understanding of the non-dopaminergic modulation of human brains.
Organizational Paradox
Authors: Gaim Medhanie , Clegg Stewart , e Cunha Miguel Pina , Berti Marco
Published: September 2022

Paradoxes, contrary propositions that are not contestable separately but that are inconsistent when conjoined, constitute a pervasive feature of contemporary organizational life. When contradictory elements are constituted as equally important in day-to-day work, organizational actors frequently experience acute tensions in engaging with these contradictions. This Element discusses the presence of paradoxes in the life of organizations, introduces the reader to the notion of paradox in theory and practice, and distinguishes paradox and adjacent conceptualizations such as trade-off, dilemma, dialectics, ambiguity, etc. This Element also covers what triggers paradoxes and how they come into being whereby the Element distinguishes latent and salient paradoxes and how salient paradoxes are managed. This Element discusses key methodological challenges and possibilities of studying, teaching, and applying paradoxes and concludes by considering some future research questions left unexplored in the field.
Relaxation of the parameter independence assumption in the bootComb R package
Authors: Henrion Marc Y. R.
Published: September 2022

Background

The bootComb R package allows researchers to derive confidence intervals with correct target coverage for arbitrary combinations of arbitrary numbers of independently estimated parameters. Previous versions (<1.1.0) of bootComb used independent bootstrap sampling and required that the parameters themselves are independent—an unrealistic assumption in some real-world applications.

Findings

Using Gaussian copulas to define the dependence between parameters, the bootComb package has been extended to allow for dependent parameters.

Implications

The updated bootComb package can now handle cases of dependent parameters, with users specifying a correlation matrix defining the dependence structure. While in practice it may be difficult to know the exact dependence structure between parameters, bootComb allows running sensitivity analyses to assess the impact of parameter dependence on the resulting confidence interval for the combined parameter.

Availability

bootComb is available from the Comprehensive R Archive Network (https://CRAN.R-project.org/package=bootComb).
Performance of a small array of Imaging Air Cherenkov Telescopes sited in Australia
Authors: Lee Simon , Einecke Sabrina , Rowell Gavin , Balazs Csaba , Bellido Jose A. , Dai Shi , Elsässer Dominik , Filipović Miroslav , Harvey Violet M. , McGee Padric , Rhode Wolfgang , Tingay Steven , White Martin
Published: September 2022

As TeV gamma-ray astronomy progresses into the era of the Cherenkov Telescope Array (CTA), there is a desire for the capacity to instantaneously follow up on transient phenomena and continuously monitor gamma-ray flux at energies above$10^{12}\,\mathrm{eV}$. To this end, a worldwide network of Imaging Air Cherenkov Telescopes (IACTs) is required to provide triggers for CTA observations and complementary continuous monitoring. An IACT array sited in Australia would contribute significant coverage of the Southern Hemisphere sky. Here, we investigate the suitability of a small IACT array and how different design factors influence its performance. Monte Carlo simulations were produced based on the Small-Sized Telescope (SST) and Medium-Sized Telescope (MST) designs from CTA. Angular resolution improved with larger baseline distances up to 277 m between telescopes, and energy thresholds were lower at 1 000 m altitude than at 0 m. The${\sim} 300\,\mathrm{GeV}$energy threshold of MSTs proved more suitable for observing transients than the${\sim}1.2\,\mathrm{TeV}$threshold of SSTs. An array of four MSTs at 1 000 m was estimated to give a5.7$\sigma$detection of an RS Ophiuchi-like nova eruption from a 4-h observation. We conclude that an array of four MST-class IACTs at an Australian site would ideally complement the capabilities of CTA.
Uncovering Sparsity and Heterogeneity in Firm-Level Return Predictability Using Machine Learning
Authors: Evgeniou Theodoros , Guecioueur Ahmed , Prieto Rodolfo
Published: September 2022

We develop an approach that combines the estimation of monthly firm-level expected returns with an assignment of firms to (possibly) latent groups, both based on observable characteristics, using machine learning principles with linear models. The best-performing methods are flexible two-stage sparse models that capture group-membership predictive relationships. Portfolios formed to exploit such group-varying predictions based on a parsimonious set of characteristics deliver economically meaningful returns with low turnover. We propose statistical tests based on nonparametric bootstrapping for our results, and detail how different characteristics may matter for different groups of firms, making comparisons to the existing literature.
The English Utilitarians, Some Recent Reconsiderations
Authors: Conti Gregory
Published: September 2022

In 1900, perhaps the greatest Victorian historian of ideas, Leslie Stephen, released his three-volume English Utilitarians. Coming to grips with the political thought of the century that had just ended, he believed, required considering the “dominant beliefs of the adherents of this school.” So privileged a point of access was offered by what we would now call “classical utilitarianism” that a study of it could serve as a “sequel” to his previous History of English Thought in the Eighteenth Century. The utilitarians, Stephen was confident, could serve as a kind of synecdoche for a whole age. Further, if the utilitarians did not grasp the whole truth, there was no doubt that their “creed” would make up part of the “definitive system” that would arrive in due time.
Heritability is a poor, if not unhelpful, measure of complex human behavioral processes
Authors: Fuentes Agustín , Bird Kevin
Published: September 2022

Heritability is not a measure of the relative contribution of nature vis-à-vis nurture, nor is it the phenotypic variance explained by or because of genetic variance. Heritability is a correlative value. The evolutionary and developmental processes associated with human culture challenge the use of “heritability” for understanding human behavior.
The implications of the cultural evolution of heritability for evolutionary psychology
Authors: Racine Timothy P.
Published: September 2022

Uchiyama et al. provide a compelling analysis of cultural influences on estimates of the genetic contribution to psychological and behavioral traits. Their focus is on the relevance of their arguments for behavioral genetics and their work resonates with other contemporary approaches that emphasize extra-genetic influences on phenotype. I extend their analysis to consider its relevance for evolutionary psychology.
Evolving the blank slate
Authors: Bates Timothy C.
Published: September 2022

We support Uchiyama et al. in the value of genetics, sample diversification, and context measurement. Against the example of vitamins, we highlight the intransigence of many phenotypes. We caution that while culture can mask genetic differences, the dependence of behaviour on genetics is reinvented and unmasked by novel challenges across generations.
Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies
Authors: Campbell Amy , Munafò Marcus R. , Sallis Hannah M. , Pearson Rebecca M. , Smith Daniel
Published: September 2022

Cultural effects can influence the results of causal genetic analyses, such as Mendelian randomisation, but the potential influences of culture on genotype–phenotype associations are not currently well understood. Different genetic variants could be associated with different phenotypes in different populations, or culture could confound or influence the direction of the association between genotypes and phenotypes in different populations.
A review of mental health disparities during COVID-19: Evidence, mechanisms, and policy recommendations for promoting societal resilience
Authors: Parenteau Anna M. , Boyer Chase J. , Campos Lillian J. , Carranza Angelica F. , Deer LillyBelle K. , Hartman Dana T. , Bidwell Julie T. , Hostinar Camelia E.
Published: September 2022

Social and economic inequality are chronic stressors that continually erode the mental and physical health of marginalized groups, undermining overall societal resilience. In this comprehensive review, we synthesize evidence of greater increases in mental health symptoms during the COVID-19 pandemic among socially or economically marginalized groups in the United States, including (a) people who are low income or experiencing homelessness, (b) racial and ethnic minorities, (c) women and lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) communities, (d) immigrants and migrants, (e) children and people with a history of childhood adversity, and (f) the socially isolated and lonely. Based on this evidence, we propose that reducing social and economic inequality would promote population mental health and societal resilience to future crises. Specifically, we propose concrete, actionable recommendations for policy, intervention, and practice that would bolster five “pillars” of societal resilience: (1) economic safety and equity, (2) accessible healthcare, including mental health services, (3) combating racial injustice and promoting respect for diversity, equity, and inclusion, (4) child and family protection services, and (5) social cohesion. Although the recent pandemic exposed and accentuated steep inequalities within our society, efforts to rebuild offer the opportunity to re-envision societal resilience and policy to reduce multiple forms of inequality for our collective benefit.
Contrasting Fate of Western Third Pole's Water Resources Under 21st Century Climate Change
Authors: Su Fengge , Pritchard Hamish D. , Yao Tandong , Huang Jingheng , Ou Tinghai , Meng Fanchong , Sun He , Li Ying , Xu Baiqing , Zhu Meilin , Chen Deliang
Published: September 2022

Seasonal melting of glaciers and snow from the western Third Pole (TP) plays important role in sustaining water supplies downstream. However, the future water availability of the region, and even today's runoff regime, are both hotly debated and inadequately quantified. Here, we characterize the contemporary flow regimes and systematically assess the future evolution of total water availability, seasonal shifts, and dry and wet discharge extremes in four most meltwater‐dominated basins in the western TP, by using a process‐based, well‐established glacier‐hydrology model, well‐constrained historical reference climate data, and the ensemble of 22 global climate models with an advanced statistical downscaling and bias correction technique. We show that these basins face sharply diverging water futures under 21st century climate change. In RCP scenarios 4.5 and 8.5, increased precipitation and glacier runoff in the Upper Indus and Yarkant basins more than compensate for decreased winter snow accumulation, boosting annual and summer water availability through the end of the century. In contrast, the Amu and Syr Darya basins will become more reliant on rainfall runoff as glacier ice and seasonal snow decline. Syr Darya summer river‐flows, already low, will fall by 16%–30% by end‐of‐century, and striking increases in peak flood discharge (by >60%), drought duration (by >1 month) and drought intensity (by factor 4.6) will compound the considerable water‐sharing challenges on this major transboundary river.
Impacts of Basal Melting of the Totten Ice Shelf and Biological Productivity on Marine Biogeochemical Components in Sabrina Coast, East Antarctica
Authors: Tamura Tetsuya P. , Nomura Daiki , Hirano Daisuke , Tamura Takeshi , Kiuchi Masaaki , Hashida Gen , Makabe Ryosuke , Ono Kazuya , Ushio Shuki , Yamazaki Kaihe , Nakayama Yoshihiro , Takahashi Keigo D. , Sasaki Hiroko , Murase Hiroto , Aoki Shigeru
Published: September 2022

To clarify the impacts of basal melting of the Antarctic ice sheet and biological productivity on biogeochemical processes in Antarctic coastal waters, concentrations of dissolved inorganic carbon (DIC), total alkalinity (TA), inorganic nutrients, chlorophyll a, and stable oxygen isotopic ratios (δ18O) were measured from the offshore slope to the ice front of the Totten Ice Shelf (TIS) during the spring/summer of 2018, 2019, and 2020. Modified Circumpolar Deep Water (mCDW) intruded onto the continental shelf off the TIS and flowed along bathymetric troughs into the TIS cavity, where it formed a buoyant mixture with glacial meltwater from the ice shelf base. Physical oceanographic processes mostly determined the distributions of DIC, TA, and nutrient concentrations. However, photosynthesis and dilution by meltwater from sea ice and the ice shelf base decreased DIC, TA, and nutrient concentrations in surface water near the ice front. These causes also reduced the partial pressure of CO2 (pCO2) in surface water by more than 100 μatm with respect to mCDW in austral summer of 2018 and 2020, and the surface water became a strong CO2 sink for the atmosphere. Phytoplankton photosynthesis changed DIC and TA in a molar ratio of 106:16. Thus, pCO2 decreased mostly as a result of photosynthesis while dilution by glacial and sea ice meltwater had a small effect. The nutrient consumption ratio suggested that photosynthesis was stimulated by iron in the water column, supplied to the surface layer via buoyancy‐driven upwelling and basal ice shelf meltwater in addition to sea ice meltwater.
How Are Mixed‐Phase Clouds Mixed?
Authors: Korolev Alexei , Milbrandt Jason
Published: September 2022

Mixed‐phase clouds are recognized as significant contributors to the modulation of precipitation and radiation transfer on both regional and global scales. This study is focused on the analysis of spatial inhomogeneity of mixed‐phase clouds based on an extended data set obtained from airborne in situ observations. The lengths of continuous segments of ice, liquid, and mixed‐phase clouds present a cascade of scales varying from 102 km down to a minimum scale of 100 m determined by the spatial resolution of measurements. It was found that the phase composition of mixed‐phase clouds is highly intermittent, and the frequency of occurrence of ice, liquid, and mixed‐phase regions increases with the decrease of their spatial scales. The distributions of spatial scales have well‐distinguished power‐law dependencies. The results obtained yield insight into the morphology of mixed‐phase clouds and have important implications for improvement in representing subgrid inhomogeneity of mixed‐phase clouds in weather and climate models.
Retrieval of CO Relative Column Abundance in the Martian Thermosphere From FUV Disk Observations by EMM EMUS
Authors: Evans J. S. , Correira J. , Deighan J. , Jain S. , Al Matroushi H. , Al Mazmi H. , Chaffin M. , Curry S. , England S. , Eparvier F. , Fillingim M. , Forget F. , Holsclaw G. , Lillis R. , Lootah F. , Thiemann E.
Published: September 2022

Carbon monoxide (CO) is a sensitive tracer of the thermal profile and winds in Mars' middle atmosphere and the chemistry that balances CO2 in the whole atmosphere of Mars. The Emirates Ultraviolet Spectrometer (EMUS) onboard the Emirates Mars Mission Hope probe images Mars at ultraviolet wavelengths from approximately 100 to 170 nm. ΣCO/CO2, the column density ratio of CO to carbon dioxide, provides a sensitive measure of CO relative variability within the Martian thermosphere. Derived from the heritage of ΣO/N2 used at Earth, the ΣCO/CO2 algorithm uses emission from the CO Fourth Positive Group band system to derive the relative column abundance of CO above ∼70 km. We describe the EMUS ΣCO/CO2 algorithm, review the Level 3 data product, and discuss preliminary validation of the algorithm. The ΣCO/CO2 algorithm produces column density ratios that characterize the spatial structure and relative variability of CO abundance in the Martian thermosphere.
Mantle Flow Pattern Associated With the Patagonian Slab Window Determined From Azimuthal Anisotropy
Authors: Ben‐Mansour Walid , Wiens Douglas A. , Mark Hannah F. , Russo Raymond M. , Richter Andreas , Marderwald Eric , Barrientos Sergio
Published: September 2022

Geological processes in Southern Patagonia are affected by the Patagonian slab window, formed by the subduction of the Chile Ridge and subsequent northward migration of the Chile Triple Junction. Using shear wave splitting analysis, we observe strong splitting of up to 2.5 s with an E‐W fast direction just south of the triple junction and the edge of the subducting Nazca slab. This region of strong anisotropy is coincident with low uppermost mantle shear velocities and an absence of mantle lithosphere, indicating that the mantle flow occurs in a warm, low‐viscosity, 200–300 km wide shallow mantle channel just to the south of the Nazca slab. The region of flow corresponds to a volcanic gap caused by depleted mantle compositions and absence of slab‐derived water. In most of Patagonia to the south of this channel, splitting fast directions trend NE‐SW consistent with large‐scale asthenospheric flow.
Geology and Stratigraphic Correlation of the Murray and Carolyn Shoemaker Formations Across the Glen Torridon Region, Gale Crater, Mars
Authors: Fedo C. M. , Bryk A. B. , Edgar L. A. , Bennett K. A. , Fox V. K. , Dietrich W. E. , Banham S. G. , Gupta S. , Stack K. M. , Williams R. M. E. , Grotzinger J. P. , Stein N. T. , Rubin D. M. , Caravaca G. , Arvidson R. E. , Hughes M. N. , Fraeman A. A. , Vasavada A. R. , Schieber J. , Sutter B.
Published: September 2022

The Glen Torridon (GT) region within Gale crater, Mars, occurs in contact with the southern side of Vera Rubin ridge (VRR), a well‐defined geomorphic feature that is comparatively resistant to erosion. Prior to detailed ground‐based investigation of GT, its geologic relationship with VRR was unknown. Distinct lithologic subunits within the Jura member (Murray formation), which forms the upper part of VRR, made it possible to be also identified within GT. This indicates that the strata pass across the geomorphic divide between regions. Furthermore, the cross‐bedded lower part of the overlying Knockfarril Hill member (Carolyn Shoemaker formation) also occurs within both VRR and GT. Correlation of both units demonstrates that the strata form a continuous stratigraphic succession regardless of large‐scale geomorphic expression. The lithologic change from mudstone (Jura member) to cross‐bedded sandstone (Knockfarril Hill member) heralds a significant shift in paleoenvironment from lacustrine to fluvial. The upper part of the Knockfarril Hill member consists of interbedded mudstone and sandstone that transitions to the overlying finely laminated mudstone of the Glasgow member, and a return to lacustrine deposition. In GT, the Stimson formation unconformably overlies the Glasgow member, where it demarks the southern boundary of GT. Contacts for each stratigraphic unit were defined and transferred to a high‐resolution image base to make a geologic map and cross sections perpendicular to the NE strike. Stratal dips cannot exceed 2° NW to retain the positions of stratigraphic units in the locations they are exposed throughout GT.
Comment on “Groundwater Affects the Geomorphic and Hydrologic Properties of Coevolved Landscapes” by Litwin et al.
Authors: Anand Shashank Kumar , Bonetti Sara , Camporeale Carlo , Hooshyar Milad , Porporato Amilcare
Published: September 2022

The objective of this comment is to correct two sets of statements in Litwin et al. (2022, https://doi.org/10.1029/2021JF006239), which consider our research work (Bonetti et al., 2018, https://doi.org/10.1098/rspa.2017.0693; Bonetti et al., 2020, https://doi.org/10.1073/pnas.1911817117). We clarify here that (a) the specific contributing area is defined in the limit of an infinitesimal contour length instead of the product of a reference contour width (Bonetti et al., 2018, https://doi.org/10.1098/rspa.2017.0693), and (b) not all solutions obtained from the minimalist landscape evolution model of Bonetti et al. (2020, https://doi.org/10.1073/pnas.1911817117) are rescaled copies of each other. We take this opportunity to demonstrate that the boundary conditions impact the obtained solutions, which has not been considered in the dimensional analysis of Litwin et al. (2022, https://doi.org/10.1029/2021JF006239). We clarify this point by using dimensional analysis and numerical simulations for a square domain, where only one horizontal length scale (the side length l) enters the physical law.
The Role of Slab Steps on Tectonic Loading Along Subduction Zones: Inferences on the Seismotectonics of the Sunda Convergent Margin
Authors: Zuhair Mohd , Gollapalli Thyagarajulu , Capitanio Fabio A. , Betts Peter G. , Graciosa Juan Carlos
Published: September 2022

How seismotectonics of convergent margins reconciles with the force balance of subduction is contentious. The comparison of seismotectonics and available slab pull forces along the Sunda convergent margin shows an enigmatic inverse relationship: upper plate thickening and seismicity magnitude are highest along Sumatra and Andaman, where the slab is shorter than ∼300 km; conversely, these are negligible along the Java segment, where the slab reaches deeper, ∼660 km. Using numerical models, we test the role of such slab pull gradients in the force balance of subduction in three‐dimensions, where the slab depth, and therefore its net pull, varies along the trench. We show that in the presence of a “slab step,” the deeper slab drives the convergence of the rigid plate, causing upper plate compression and trench advance in the neighboring trench segments, where a short slab may have no pull to subduct the incoming plate. While neglecting convergence obliquity, the simplified models show relevant along‐trench variations of coupling, trench rotations, and minor strike‐slip shearing due to the slab step, providing a diagnostic strain pattern, with compression/extension atop the short/long slab and minor strike‐slip, increasing in magnitude with depth difference. The modeled tectonic patterns are compared to Sunda margin deformation across scales, from the Cenozoic tectonics to the seismic strain rates, showing remarkable consistency with deformation gradients from Sumatra to Java, potentially illustrating the contribution of the slab step to the seismotectonics of the region.
Light-driven high-precision cell adhesion kinetics
Authors: Zhang Zhiyuan , Ahmed Daniel
Published: September 2022

Existing single-cell adhesion kinetics methods are performed under conditions highly unlike the physiological cell adhesion conditions. Now, researchers have developed a new optical technique for high-precision measurement of cell lateral adhesion kinetics in complex clinical samples.
Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders
Authors: Garrido Débora , Beretta Stefania , Grabrucker Stefanie , Bauer Helen Friedericke , Bayer David , Sala Carlo , Verpelli Chiara , Roselli Francesco , Bockmann Juergen , Proepper Christian , Catanese Alberto , Boeckers Tobias M.
Published: September 2022

Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is showing severe autism related core symptoms, as well as a broad spectrum of comorbidities. We exploited this animal model to identify cortical brain areas linked to specific autistic traits by locally deleting Shank2 and Shank3 simultaneously. Our screening of 10 cortical subregions revealed that a Shank2/3 deletion within the retrosplenial area severely impairs social memory, a core symptom of ASD. Notably, DREADD-mediated neuronal activation could rescue the social impairment triggered by Shank2/3 depletion. Data indicate that the retrosplenial area has to be added to the list of defined brain regions that contribute to the spectrum of behavioural alterations seen in ASDs.
Trait anxiety is associated with amygdala expectation and caloric taste receipt response across eating disorders
Authors: Frank Guido K. W. , Shott Megan E. , Pryor Tamara , Swindle Skylar , Nguyen Tyler , Stoddard Joel
Published: September 2022

Anxious traits are elevated in eating disorders (EDs), are considered risk factors for ED development, and trait anxiety has been linked to ED psychopathology. How trait anxiety relates to ED neurobiology is not well understood. In this study 197 individuals across the ED spectrum (anorexia nervosa n = 91; other specified EDs n = 34; bulimia nervosa n = 56; binge ED n = 16), and 120 healthy controls were assessed for anxious traits and learned to expect and receive caloric or neutral taste stimuli during brain imaging. Amygdala sucrose expectation response differed across groups (Wilk’s lambda = 0.945, p = 0.023), and was higher on the left in anorexia nervosa compared to healthy controls (p = 0.002). Expected sucrose receipt response across taste reward regions was not different between groups. In the ED sample, trait anxiety negatively moderated the relationship between amygdala expectation and right dorsal (p = 0.0062) and ventral (p = 0.0046) anterior insula receipt response. A subgroup analysis showed similar results for anorexia nervosa, and partially in bulimia nervosa. Across EDs, appetitive motivation correlated positively with bilateral orbitofrontal cortex, caudate head, and ventral striatal sucrose receipt response (r = 0.215 to 0.179, p = 0.002 to 0.012). Across the study sample, trait anxiety showed an inverted-U-shaped relationship with right (r = 0.147, p = 0.034) and left (r = 0.162, p = 0.016) amygdala expectation response. Amygdala sucrose expectation response is elevated in anorexia nervosa, correlates with sucrose receipt response, and this relationship is negatively moderated by trait anxiety across EDs. Trait anxiety may have an important role in how expectation drives taste stimulus receipt brain response and perhaps food approach in individuals with EDs.