bluuebunny/crossref_metadata_2025 huggingface dataset:
Physical Activities: The Most Natural Preventive Way against Tumor
Authors: Wakai Kazuya
Published: February 2025

Participating in physical activities has been demonstrated to be one of the most efficacious natural methods for preventing and combating cancer. Research indicates that consistent physical activity can diminish the likelihood of getting specific cancer types, such as breast, colon, and lung cancer. Physical activity aids in sustaining a healthy body weight, enhancing immunological function, and diminishing inflammation—elements that collectively minimize cancer risk. Furthermore, physical activity can enhance the overall mental well-being and quality of life for individuals diagnosed with cancer and those in remission. Healthcare practitioners recommend that persons engage in a minimum of 150 minutes of moderate-intensity exercise weekly to obtain the cancer-preventive advantages of physical activity. Incorporating regular physical activity into one's lifestyle enables individuals to proactively mitigate their cancer risk and enhance overall well-being.
Multiple Sclerosis: Where Does It Exactly Stem From?
Authors: Hennig Arno
Published: February 2025

Multiple sclerosis (MS) is a complicated, multifaceted autoimmune disorder marked by damage to the myelin sheath of the central nervous system. The precise etiology of MS remains incompletely elucidated, though it is thought to arise from an interplay of genetic and environmental influences. Genetic predisposition contributes to the likelihood of acquiring MS, particularly in persons with a familial history of the illness. Moreover, environmental factors such as viral infections, vitamin D insufficiency, smoking, specific dietary practices, and exercise lacking have been associated with the initiation of an aberrant immune response that results in inflammation and demyelination within the central nervous system. Researchers persist in examining the complex underpinnings of MS to formulate more effective treatments and interventions for individuals impacted by this chronic neurological disorder.
СОЦІАЛІЗАЦІЯ НАЦІОНАЛЬНО УКОРІНЕНОГО РОЗВИТКУ
Authors: Геєць В.
Published: February 2025

Вступ. Соціальний простір у вимірі соціальної якості життя визначається соціалізацією загалом і економічною соціалізацією зокрема.Проблематика. Процеси, що мають фундаментальний характер з акцентом на національну укоріненість, даютьможливість уникати невпорядкованості в суспільному розвитку шляхом соціального проєктування реальності, оскільки останнє передбачає наявність у суспільстві інституційного порядку, завдяки чому нівелюється зростання соціальної ентропії.Мета. Розкрити і продемонструвати те, як соціалізація укорінення національного розвитку, формуючи здатність продукувати енергію творчості, стає джерелом ресурсів та механізмів оновлення життєдіяльності.Матеріали та методи. Використано матеріали міжнародних та національних соціологічних обстежень та дані Державної служби статистики, МВФ, національних наукових установ. Застосовано абстрактно-логічний, монографічний, порівняльний метод, методи соціальних та статистичних спостережень.Результати. Охарактеризовано складові соціальної та економічної політики в частині досягнення інституційноївпорядкованості та її практичної результативності шляхом як державного соціального проєктування реальності, так і формування інтеріоризаційного характеру діяльності особистостей.Висновки. В умовах повномасштабного вторгнення російської федерації український соціальний простір зазнав суттєвої реструктуризації, що зумовило формування нових структуроутворюючих опор життєдіяльності: масштабної гуманітарної допомоги збіднілим верствам населення; зміни балансу довіри/недовіри до окремих суспільних інститутів; переоцінки цінностей і бажання почати «нове життя» з новою роботою. У сукупності саме вони становлятьнові засадничі форми життєдіяльності українського соціуму і мають розглядатися в Плані повоєнного відновлення з акцентуванням на національно укоріненому розвитку.
Analysis of Land Use in the Seaside Regions of Ukraine in 2017—2022 Based on Satellite Information
Authors: SRYBERKO A. , PETRUSHENKO M. , STEPANOVA Yu.
Published: February 2025

Introduction. Land is recognized as a primary national asset under the special protection of the state, as mandated by Ukrainian law. It serves as the foremost natural resource, a vital foundation for human life and activity, and underpins the establishment and development of all sectors of the national economy. Therefore, an eff ectively organized, sustainable economy is unattainable without the rational utilization and protection of land resources.Problem Statement. Research on land use in Ukraine’s coastal regions has become especially relevant. Since parts of these areas have been under occupation since 2014, understanding the spatial-temporal variability of land use in these regions presents significant challenges for Ukraine.Purpose. To analyze land use in the coastal regions of Ukraine using satellite data to assess spatio-temporal changes.Materials and Methods. This research utilized land use/land cover (LULC) mapping based on satellite data from Sentinel-2, analyzed through deep learning models using artificial neural networks.Results. The spatial distribution of land use in Ukraine’s coastal regions in 2022 was thoroughly analyzed. Additionally, the spatio-temporal variability of land use from 2017 to 2022 was assessed, revealing distinctive patterns in the spatial distribution of various land cover classes. The findings show that the innovative approaches to LULC mapping and the resulting data can be effectively applied to land resource management in Ukraine.Conclusions. The LULC mapping approach demonstrates significant potential for interdisciplinary research and applied work in natural resource management and territorial planning at both the national and regional levels. Moreover, these innovative LULC mapping methods present a robust tool for identifying and understanding the scale of natural, anthropogenic, and military-induced emergencies.
ПОЛІМЕРНІ КОМПОЗИЦІЙНІ МАТЕРІАЛИ СПЕЦІАЛЬНОГО ПРИЗНАЧЕННЯ ДЛЯ АВІАЦІЙНОЇ ТА КОСМІЧНОЇ ПРОМИСЛОВОСТІ
Authors: Кабат О. , Банник Н. , Вороний О.
Published: February 2025

Вступ. Розвиток авіаційної та космічної промисловості сприяє не тільки створенню сучасних літаків, ракет та космічних апаратів, а й позитивно впливає на суміжні галузі промисловості.Проблематика. Однією із основних вимог до продукції авіаційної та космічної промисловості є високий рівень її надійності та довговічності, що обумовлено постійною взаємодією із людьми та досить високою собівартістю виготовлення й експлуатації. Найбільш актуальним це є для сучасних літаків, ракет та космічних апаратів, які експлуатуються при більших швидкостях, температурах, навантаженнях тощо, ніж попередники. Тому підвищення надійності й довговічності у роботі продукції авіаційної та космічної промисловості є актуальним напрямком.Мета. Підвищити надійність та довговічність основних вузлів ракето-космічної техніки за рахунок заміни матеріалів, з яких вони виготовлені, на власні інноваційні розробки.Матеріали й методи. Об’єктами досліджень були полімерні композиційні матеріали на основі фторполімерів та ароматичних поліамідів, які наповнені дисперсними матеріалами на основі діоксиду кремнію та вуглецю.Результати. Розроблено склад та технології переробки у вироби полімерних композиційних матеріалів на основі фторполімерів та ароматичних поліамідів. Встановлено, що за рівнем міцності (до 285 МПа) вони перевищують більшість кольорових металів, їніх сплавів і низьковуглецевих сталей, маючи при цьому низьку густину (до 1400 кг/м3). За теплофізичними властивостями вони належать до найбільш термостійких матеріалів на основі полімерів (не підлягають термічному розкладанню до температур +365 oС). Показано, що деталі із розроблених матеріалів можуть працювати у вузлах тертя без змащування у нормальному режимі роботи при навантаженнях до 2,5 МПа.Висновки. Розроблено полімерні композиційні матеріали на основі фторполімерів та ароматичних поліамідів з високим рівнем властивостей, деталі з яких значно покращують рівень надійності та довговічності сучасних літаків, ракет і космічних апаратів.
Temperature-controlled Ablation Versus Conventional Ablation for Pulmonary Vein Isolation in the Treatment of AF: A Systematic Review and Meta-Analysis
Authors: Clay Benjamin , Sokhal Balamrit S , Zeriouh Sarah , Srinivasan Neil T , Gajendragadkar Parag R , Martin Claire A
Published: February 2025

Background: This study compared the efficacy and safety of temperature-controlled and conventional contact-force-sensing radiofrequency ablation catheters for pulmonary vein isolation (PVI) in AF. Methods: Seven studies (1,138 patients) were included. Randomised controlled trials and observational (single-arm and two-arm) studies that reported freedom from AF ≥3 months after PVI with temperature-controlled radiofrequency ablation catheters (Biosense Webster QDOT MICRO operating in QMODE or Medtronic DiamondTemp) were included. Results: Freedom from AF at a mean (± SD) follow-up of 9.0 ± 3.6 months did not differ significantly between temperature-controlled and conventional ablation (OR 1.22; 95% CI [−0.79, 1.64]; p=0.24). Total procedure duration (−13.5 minutes; 95% CI [−17.1, −10.0 minutes]; p<0.001) and total ablation duration (−8.9 min; 95% CI [−10.3, −7.5 min]; p<0.01) were significantly shorter for temperature-controlled ablation. There were no significant differences between temperature-controlled and conventional ablation in either the aggregated rates of procedural complications (OR 0.69; 95% CI [−0.15, 1.54]; p=0.11) or in the rate of any individual complication. Conclusion: Temperature-controlled ablation was found to be at least non-inferior to conventional ablation in all measures of efficacy and safety. Further randomised controlled trials are warranted to evaluate long-term rates of freedom from AF and patient comfort.
Stresszkezelési stratégiák és prevenciós lehetőségek hatékonysága a magyar sürgősségi betegellátásban
Authors: Ferkai Luca Anna , Schiszler Bence , Bánfai Bálint , Pandur Attila , Gálos Gergely , Kívés Zsuzsanna , Sipos Dávid , Takács Krisztina , Betlehem József , Stromájer-Rácz Tímea , Deutsch Krisztina
Published: February 2025

Bevezetés: A sürgősségi betegellátásban dolgozó szakemberek
munkájuk során gyakran szembesülnek intenzív fizikai és mentális stresszel,
amely jelentős hatást gyakorol egészségi állapotukra és munkájuk minőségére.
Célkitűzés: A tanulmány célja, hogy felmérje a magyar
sürgősségi betegellátásban dolgozó szakemberek stresszkezelési stratégiáinak
hatékonyságát és a rendelkezésre álló prevenciós lehetőségeket.
Módszer: A kutatás egy keresztmetszeti vizsgálat, amely
2023 januárja és 2024 márciusa között zajlott a Dél-dunántúli Régióban. A
vizsgálat során 202 sürgősségi betegellátó szakember adatait elemeztük,
különböző időpontokban rögzített fiziológiás paraméterek (vérnyomás,
szívfrekvencia), a szubjektív feszültségérzet mértéke, továbbá nyál- és
hajmintából mért kortizolértékek segítségével. Mann–Whitney-féle U-tesztet,
χ2-próbát, Wilcoxon-próbát, Kruskal–Wallis-tesztet és ismételt
méréses ANOVA-vizsgálatot alkalmaztunk. Az adatfeldolgozás IBM SPSS Statistics
26.0, G*Power 3.1 és Matplotlib 3.9.1 szoftverekkel történt.
Eredmények: A résztvevők többsége hosszú műszakokban,
gyakran éjszaka dolgozik, másodállás mellett. A sürgősségi osztályokon ötször
akkora betegforgalom volt mérhető, mint prehospitálisan, és több mentálisan
megterhelő eset fordult elő. A résztvevők főként családtagjaikra, kollégáikra és
barátaikra támaszkodnak, kevesen kérik ki azonban mentálhigiénés szakember
segítségét (7,4%). Riasztáskor a mentődolgozóknál a vérnyomás 10,7%-kal, a
szívfrekvencia 15,3%-kal nőtt, a feszültségérzet pedig 1,7-szeresére emelkedett
(p<0,001). A sürgősségi osztályokon a vérnyomás 8,5%-kal, a szívfrekvencia
11,9%-kal emelkedett, a feszültségérzet pedig 2,5-szeresére nőtt (p<0,001). A
munkahelyi környezet és a betegellátás folyamata mindkét helyszínen emelte a
betegellátók kortizolszintjét (p<0,001). A hajmintákban mért értékek
magasabbak voltak a sürgősségi osztályokon dolgozók esetében, ami a hosszú távú
stressz felhalmozódását tükrözi. A mentődolgozók közül a központi állomásokon
szolgálatot teljesítők esetében magasabb kortizolszint volt mérhető, mint a
peremállomásokon dolgozóknál. Következtetés: A hazai sürgősségi
betegellátók körében a distressz jelentős mértékben van jelen, különösen a nagy
betegforgalommal és hosszú műszakokkal jellemezhető munkakörnyezetben, ami
hosszú távon egészségügyi kockázatot jelent. A mentális egészségmegőrző és
stresszkezelési gyakorlatokat a mindennapok részévé kell tenni, továbbá a
kommunikáció hatékonyságát többcsatornás tájékoztatással és személyes
konzultációkkal kell javítani. A társas támogatás és a munkahelyi mentálhigiénés
szolgáltatások szisztematikus fejlesztése elengedhetetlen a krónikus stressz és
a kiégés megelőzéséhez. Orv Hetil. 2025; 166(5): 183–194.
Fejlett technológiák és innovatív megközelítések a neuromusculoskeletalis rehabilitációban
Authors: Sándor Krisztina , Fazekas Gábor
Published: February 2025

Az utóbbi években a rehabilitációban egyre nagyobb szerepet kapnak a fejlett
technológián alapuló eszközök. A modern eszközök, mint a virtuális és
kiterjesztett valóság, az exoskeletonok, az end-effektorok és a
testsúlytámogatott járástréning nagy előnyt jelenthetnek a mozgás és a kognitív
funkciók helyreállításában, ha a hagyományos terápiákkal együtt alkalmazzák
őket. Protokollok és irányelvek kialakítása és alkalmazása szükséges ahhoz, hogy
a modern technológiák használata a rehabilitációban szabályozott és tudományos
bizonyítékokon alapuló legyen. A fejlett technológián alapuló eszközök
használata speciálisan képzett terapeutákat igényel, akik jártasak az eszközök
használatában. A terapeuták kulcsszerepet játszanak nemcsak a megfelelő eszköz
kiválasztásában, a terápiás terv kidolgozásában és a hagyományos gyógytorna
alapelvein nyugvó kezelések kivitelezésében, hanem a páciensek motiválásában is,
ami fontos a hosszabb kezelési folyamatok alatt. További kutatások szükségesek,
hogy az eszközök eredményességét és alkalmazási módjait jobban megismerhessük,
és új irányelvek születhessenek a gyakorlati használat támogatására. Az eszközök
költséghatékonyságának javítása szintén fontos, mivel ez biztosíthatja a
technológia szélesebb körű, akár otthoni elérhetőségét. Összességében a modern
technológián alapuló megoldások széles körű elérhetősége és az egészségügyi
szakemberek általi elfogadása hosszú távon új perspektívákat kínálhat a
rehabilitáció számára. Orv Hetil. 2025; 166(5): 175–182.
Evaluation of Blood Sample Collection Tubes Using Deep Learning
Authors:   Universidad Autónoma de Baja California, Franco-Alucano Ignacio , Aguilar-Duque Julian ,   Universidad Autónoma de Baja California, Baez-Lopez Yolanda ,   Universidad Autónoma de Baja California, Limon-Romero Jorge ,   Universidad Autónoma de Baja California, Solís-Quinteros María Marcela ,   Universidad Autónoma de Baja California, Tlapa Diego ,   Universidad Autónoma de Baja California
Published: February 2025

Phlebotomy is a procedure to obtain blood samples, mainly for laboratory clinical analysis. The amount of blood, tube identification, and the use of the appropriate tube are characteristics that the health professional visually inspects. Being a manual activity, the possibility of error is latent and can affect quality, workflow, and efficiency. Despite the advancement of industry 4.0 technologies, including artificial intelligence (AI), there is little evidence of applications in clinical laboratories. This study aims to evaluate the suitability of using deep learning (DL) in inspecting tubes with blood samples. Specifically, three architectures, YOLOv5, YOLOv7, and YOLOv8, are tested to detect six classes, including cap color and the presence of labels. The highest precision performance was presented by the YOLOv8 model, obtaining a precision of 0.927 in detection, which shows a high capacity to inspect important characteristics in the phlebotomy service. Therefore, being DL is a suitable alternative to assist health professionals in inspection activities. Future work includes expanding the number of images in a balanced manner.
Vector Digestion and Purification v2
Authors: Lopez Carolina
Published: February 2025

Protocol for plasmid digestion and purification
Standardized Preparation of Fecal Microbiota Transplantation Products for Companion Animals v1
Authors: K. Randolph Nina
Published: February 2025

Step-by-step protocols for standardized fecal microbiota transplantation (FMT) preparation for dogs and cats, including: Protocol 1: Standardized FMT Preparation for Double Centrifuged Fecal Slurry Protocol 2: Encapsulation of Fecal Slurry for Oral Capsular FMT Administration Protocol 3: Standardized FMT Preparation for Lyophilized FMT Products Protocol 4: Fecal Lyophilization and Encapsulation of Lyophilized Fecal Slurry for Oral Capsular FMT Protocol 5: Standardized FMT Preparation for Fecal Slurry without Centrifugation
Plasmids transfection using Mirus TransIT-LT1 v1
Authors: Lopez Carolina
Published: February 2025

Protocol for in culture cell transfection using the Mirus TransIT-LT1 transfection reagent
qPCR – Power SYBR Green Protocol v1
Authors: Lopez Carolina
Published: February 2025

Protocol for qPCR using SYBR Green
IFA and FISH combined protocol v2
Authors: Lopez Carolina
Published: February 2025

This protocol describes the procedures for staining preps with both RNA FISH and immunofluorescence
Lung processing and fixation for cryosectioning v2
Authors: Lopez Carolina
Published: February 2025

This protocol describes the fixation of lung tissue before cryopreservation. This protocol is required when the tissue will be used for staining intracellular proteins.
Expression of microRNA-16-5b, microRNA-27a, -34a-5p, -125b, -181 and -193b in cutaneous melanoma tissue
Authors: Bogdanova V. A. , Spirina L. V. , Chizhevskaya S. Yu.
Published: February 2025

Aim. To study the expression of microRNA-16-5b, -27a, -34a-5p, -125b and -193b in melanoma tissue depending on the clinical and morphological characteristics of the tumor.

Materials and methods. The study included 21 patients with a verified diagnosis of cutaneous melanoma. The expression of miR-16-5b, -27a, -34a-5p, -125b and -193b were studied in tumor tissue by real-time polymerase chain reaction. The patients are divided into 5 groups. The group 1 included patients with a tumor <0.75 mm thick (according to the Breslow classification), group 2 – 0.75–1.5 mm, group 3 – 1.51–3 mm, group 4 – 3–4 mm, group 5 – >4 mm. The control group consisted of 10 patients with skin nevi.

Results. The expression of microRNA-27a-3p was reduced in group 5 compared to group 2 by 1.7 times. At the same time, the expression of microRNA-16-5b was, on the contrary, increased by 21.7 times in group 5 compared to groups 3 and 4. Multidirectional changes in microRNA expression were revealed when comparing parameters in groups differing in the depth of invasion. There was a 4.0-fold decrease in the expression of microRNA-27a in the group with Clark invasion III compared to the group with Clark invasion II, which was accompanied by an increase in the expression of microRNA-16-5b and microRNA-125 by 8.7 and 19.8 times, respectively. Moreover, the presence of signs of ulceration was associated with a low level of expression of microRNA-27a-3p against the background of an increase in the expression of the transcription factor microRNA-16-5b and microRNA-34a-5p.

Conclusion. Thus, the features of microRNA expression in melanoma tissue have been identified. Changes in the expression of microRNA-27a-3p, -16-5b, -34a-5p and -125b are associated with the depth of its invasion and the presence of signs of invasive growth.
Locally advanced angiosarcoma of the facial skin and scalp (a clinical case)
Authors: Bagdasarova D. V. , Leukhina I. A. , Kolomeitseva A. A. , Vertieva E. Yu. , Kokosadze N. V. , Mamontova I. S. , Fedenko A. A.
Published: February 2025

Angiosarcoma is a rare malignant neoplasm that develops from endothelial cells and can affect any tissue and organ, but most commonly the skin of the head and neck. This tumor is characterized by aggressive progression and early hematogenous metastasis, which leads to an unfavorable prognosis and underscores the importance of diagnosing this pathology at its early stages. Early detection of angiosarcomas is quite challenging due to the complexity of differential diagnosis and establishing a pathomorphological diagnosis. The article presents a clinical case of treatment for locally advanced angiosarcoma of the facial skin and scalp, demonstrating the aggressiveness of this rare tumor and the relevance of its early diagnosis.
Bone-modifying therapy in arthroplasty
Authors: Bukharov A. V. , Erin D. A. , Derzhavin V. A. , Yadrina A. V. , Elkhov D. O. , Aliev M. D. , Khuseynzoda Z. Kh.
Published: February 2025

The use of bisphosphonates in medicine began in the 60s of the XX century due to their ability to prevent the dissolution of hydroxyapatite and thereby to reduce bone loss. Since the mid-80s of the XX century, they began to be regularly prescribed for hypercalcemia. Currently, the most used bisphosphonate is zoledronic acid. Indications for its use are osteoporosis, metastatic bone damage and hypercalcemia caused by a malignant tumor. Denosumab, which together with zoledronic acid belongs to the pharmacological group of osteomodifying agents, is also used in these pathologies. Thе drug is used to treat giant cell tumour.

In the last 5 years, there has appeared the information on the use of bisphosphonates and denosumab to prevent aseptic instability, the most common complication of large joint endoprosthetics. According to the few data in the literature, significant improvement in periprosthetic bone mineral density is shown when using these drugs. Denosumab is more effective as compared to bisphosphonates. There is no reliable evidence of reduction in the risk of development of aseptic instability of the endoprosthesis with the use of bone-modifying agents. When prescribing bisphosphonates and denosumab, it is necessary to take into account adverse events associated with their use. In our opinion, using bone-modifying agents in patients after oncological endoprosthetics is reasonable in cases of high risk of aseptic instability. During primary endoprosthetics, their use should be avoided.

The aim of the work is to assess the effect of BMA on the condition of the periprosthetic bone after endoprosthesis, as well as their effectiveness in preventing aseptic instability during oncological endoprosthesis of long bones.
Clinical case of congenital pigmented giant nevus treatment
Authors: Zamilov M. M. , Menshikov K. V. , Galyamov A. U. , Musin S. I. , Sultanbaev A. V. , Zamilova G. I. , Nguyen A. Kh. , Ayupov R. T. , Izmailov A. A.
Published: February 2025

The article presents a clinical case of congenital pigmented giant nevus treatment located on the skin of the right gluteal region in a 26-year-old patient. Considering the size and localization of the nevus, we used the method of expander dermotension, which allowed us to perform surgery in 2 stages and achieve a satisfying cosmetic results.
Prognostic value of gene expression profiling in melanoma: a systematic literature review
Authors: Samoilenko I. V. , Belenkaya Ya. V. , Kharkevich G. Yu. , Orlova K. V. , Mikhailova I. N. , Baryshnikov K. A. , Vishnevskaya Ya. V. , Demidov L. V.
Published: February 2025

Introduction. Skin melanoma, despite having similar clinical and histological characteristics, can have different prognoses. Gene expression profiling potentially allows for more accurate risk stratification of patients.

Aim. To study prognostic test systems for assessing outcomes in patients with skin melanoma based on the analysis of primary tumors.

Materials and methods. A systematic literature review (scoping review) was conducted in accordance with PRISMA-ScR principles. The search was performed in PubMed (2008–2024). Two independent reviewers conducted the study selection and data analysis to assess concordance. The data were presented descriptively.

Results. Out of 149 identified publications, 31 studies were included in the review. The effectiveness of four test systems was evaluated, with the most frequently used being DecisionDx-Melanoma (19/31, 61.3%). This test stratifies patients by molecular classes: patients at high risk were found to have a 5.33 (±1.25) times higher likelihood of disease progression and poorer survival rates compared to lower-risk patients. No studies included data on the Russian population.

Conclusions. Gene expression profiling demonstrates high accuracy in predicting outcomes for patients with skin melanoma.
Brachytherapy in soft tissue sarcomas (literature review)
Authors: Burov D. A. , Fedoseenko D. I. , Petrochenko N. S. , Kozlov O. V. , Salkov A. G. , Bokhyan B. Yu. , Chernykh M. V. , Valiev A. K.
Published: February 2025

The article presents an analysis of publications on the effectiveness of brachytherapy in the soft tissue sarcomas. It has been shown that this method is an important part of the combined treatment of this pathology and the indications for its use are constantly expanding. The authors point to a high level of local control of the disease (from 50 to 96 % of cases). The greatest effectiveness of brachytherapy is observed in combination with surgical tumor removal.
Predictors of subclinical metastasis to non-sentinel lymph nodes for patients having clinically localized cutaneous melanoma
Authors: Abramova O. E. , Kudryavtsev D V. , Kurilchik A. A. , Ivanov S. A.
Published: February 2025

Introduction. The use of modern adjuvant drug therapy in cases of cutaneous melanoma with sentinel lymph node (LN) (SLN) metastases reduced frequency of performance of completing lymphadenectomy. However, until now, domestic and foreign clinical recommendations indicate possibility of using this procedure in patients with an unfavorable prognosis while criteria are not provided for assessing the risk of non-sentinel LN (NSLN) damage and the need to perform lymphadenectomy.

Aim. To identify predictors of high risk of metastasis in NSLN in patients with cutaneous melanoma with subclinical metastases in SLN.

Materials and methods. The study included 92 patients with clinically localized cutaneous melanoma (cT1–4N0M0), who showed subclinical lesions as a result of SLN biopsy, and therefore underwent a final lymphadenectomy.

Results. In the examined group, 26 (28.3 %) patients, along with SLN lesions, showed metastases in NSLN. Recognition of several active LNs during radionuclide mapping of SLNs is associated with a significantly higher risk of NSLN damage – in 42.3 % vs 15.2 % in the group with radiopharmaceutical activity only in SLNs (p = 0.018). Tumors thickness of >2 mm is also associated with a high frequency of NSLN metastasis (100 % of cases). No metastasis to other LNs was observed in tumor thickness of <2 mm. In ulcerated melanomas, the incidence of NSLN lesions was 92.3 % (p = 0.02). Only subcapsular localization of SLN metastases is associated with a relatively low incidence of NSLN metastasis (13.3 % of cases) as compared with parenchymal, mixed localization, and multifocal lesion (42.9 % of cases) (p = 0.002). For SLN metastases > 4 mm in size, a incidence of NSLN damage was higher than for metastases of <4 mm in size (43.3% vs 19.3%; p <0.05), as that for invasion of LN structures of > 2 mm in size versus invasion of <2 mm in size (44.4% vs 15.7 %; p = 0,003). The identified predictors of NSLN involvement in practice are often combined forming a pattern of predictors. The number of prognostic parameters in the pattern has a significant effect on the incidence of NSLN lesions (<0.001). In particular, the presence of 2 or less predictors is associated with low risk of metastasis in NSLN (0–12.5 % of cases), 3-5 predictors - with a relatively high risk (37.5–44.4 % of cases), 6 predictors – with a very high risk (80 % of cases).

Conclusion. Recognition of predictors of metastasis in NSLN and their number allows us to decide on the need to perform final lymphadenectomy in patients with cutaneous melanoma with subclinical metastases in SLN. Conducting the final lymphadenectomy in patients with a high risk of multiple lesions of regional LNs will provide better locoregional control over stage III cutaneous melanoma and will create optimal conditions for adjuvant drug therapy.
Three-dimentional problems of controlling the dynamics of incompletely observed thick elastic plates. Part I. The case of continuously specified desired condition
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Stoyan Volodymyr , Cherniy Dmytro ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Voloshchuk Sergiy ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

In the three-dimensional formulation for the first time complex problems of controlling the elastic plate’s dynamics on reaching by the field its elastic-dynamic displacements continuously for the spatially-temporal coordinates of a given desired state are solved. The classical equations of the three-dimensional theory of elasticity and the root mean- square control criterion were chosen as output data for solving the considered problems. Controlling can be volumetric, initial, surface and end external- dynamic disturbances, considered separately and in practical justified combination. The problems are formulated and solved on the condition of continuously defined initial-boundary observations for the plate’s state, which without restriction on their quantity and quality are defined functionally through linear differential operators of arbitrary order and structure. Observed system’s characteristics are modelled discretely and continuously defined by the simulation functions, numerical values and analytics of which are outside the considered spatial-temporal domain of functioning of the studied elastic body in the result of the construction of root mean-square approximations to linear algebraic, integral and functional equations’ solutions. Calculation formulas, which determine the set of admissible solutions of the considered problems are quite simple and accessible for computer implementation. The defined peculiarities of controlling the considered elastic object’s dynamics are determined for cases when the initial and boundary external-dynamic disturbances can be neglected, and the plate’s dynamics can be considered in unrestricted spatial and temporal domains. Assessment of the accuracy of control problems’ solving has been made, conditions for unambiguousness of the constructed solutions have been formulated.
Formulas for determinant and characteristic polynomial of seven-like matrices
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Fisunenko Artem
Published: February 2025

Finding the determinant and characteristic polynomial is the classic problem of linear algebra that arises in some applications utilizing matrices. There exist formulas and algorithms for calculating the determinant and characteristic polynomial of matrices with general structure, however, in some cases, a matrix has a special structure that lets the determinant and/or characteristic polynomial be calculated more efficiently. E.g., the determinant of upper and lower triangular matrices can be calculated as a product of their diagonal entries in time, linear in terms of the matrix’s size.

In this paper, we derived the formulas and algorithms for determinant or determinant and characteristic polynomial of what we called seven-like matrices, which include the matrix introduced in M. B. Usher’s renewable resources management model, by utilizing the properties of determinants and characteristic polynomials, and the seven-like matrices’ special structure.

We implemented our algorithms in Python 3.10.4 and tested their correctness on different values of matrix’s size and its elements. In all these experiments, the results matched the reference values, some up to a negligibly small relative error due to the floating-point arithmetic.

The proposed algorithms have linear computational time complexity, therefore, for seven-like matrices, they are more asymptotically time-efficient than the most asymptotically time-efficient currently known algorithms for finding the determinant and characteristic polynomial, respectively, of the matrices with general structure, and thus our algorithms can be utilized in the applications with seven-like matrices (including applications of Usher’s model). Runtime measurements can be conducted in our further research to practically verify these asymptotics.
Varieties of pure first-order logics of partial quasiary predicates
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Shkilnyak Stepan
Published: February 2025

Classical predicate logic typically lies at the basis of various logical systems successfully used in computer science and programming. However, classical logic has fundamental limitations that complicate its application. Therefore, the task of developing new, program-oriented logics becomes important; this highlights the relevance of the proposed research. In this work we study new program-oriented logical formalisms – pure first-order composition-nominative logics of partial quasiary predicates, PCNL. Depending on the presence and type of special predicates-indicators, and equality predicates (weak or strong), the use of traditional or extended renomination, in this paper we specify a number of classes of PCNL. Special predicates-indicators determine the presence of components with the corresponding subject name in the input data, which is necessary to consider for the quantifier elimination in the logics of non-monotonic predicates. Two types of these predicates can be distinguished: total, which determine the presence or absence of a component with a given name, and partial, which only detect the presence of such a component. We propose partial predicates-indicators and the corresponding classes of PCNL. The basic compositions of these logics are described, and their properties are presented. The languages of the introduced classes of logics are specified, and a number of logical consequence relations for these languages are defined. The characteristics of these relations are investigated, and the relationships between them are provided.
Packet quantization of the electromagnetic field using elementary wave packets as basis functions
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Ovechko Volodymyr
Published: February 2025

The possibility of positional localization of a photon in space is shown. The proposed technique is based on the use of operators for the creation and destruction of photon packets and corresponding wave packets. As the latter, an orthonormal series of elementary wave packets (EWP), proposed in 2009 to describe, in particular, femtosecond optical pulses, was used. The electromagnetic structure of photons and the formula for their energy have been obtained. The latter depends on the ratio of the order of the EWP function n to the duration of the photon pulse τ. Therefore, the structure of a photon at a fixed energy can be different, in particular, at n ≫ 1, it turns into an ordinary harmonic signal. The results were used to write down a modified formula for the thermal radiation of an absolutely black body - Planck's formula.
Application of texture analysis to study the relationship between surface microrelief and laser speckles
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Yakunov Andrii , Sachko Artem ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

The aim of the study was to establish a quantitative relationship between the structural properties of metal surfaces and the properties of laser speckle patterns that arise from the reflection of laser radiation on such surfaces. A texture analysis of the surfaces of seven different metal samples with different microreliefs was carried out. Two types of images were obtained for each sample: a surface micrograph taken with a microscope and a laser speckle pattern. To quantify the textures, the following parameters were calculated: fractal dimension, anisotropy, contrast, correlation, entropy, second angular momentum and energy. To determine quantitative dependencies between the texture parameters of micrographs and speckle images, pairwise regression and correlation analysis was performed. The study found a significant correlation between structural parameters of photomicrographs and speckle patterns such as fractal dimension, anisotropy and entropy. These results open up new possibilities for non-destructive quality control of materials. In addition, analyzing speckle patterns can predict material properties such as strength, corrosion resistance and wear resistance. This opens up prospects for the development of new materials with specific properties and the optimization of technological processes.
Leveraging K8s to implement PARKS.NET
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Bohusevych Oleksii , Derevianchenko Oleksandr ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

An approach to implementing PARCS (Parallel Asynchronous Recursive Control System) based on the Kubernetes container orchestration technology is presented. Its automated deployment is then exemplified by employing Microsoft Azure, a platform providing a managed solution for the technology’s infrastructure. Finally, the system is utilized to tackle an applicable mathematical problem, demonstrating the proposed framework's ease of use, speed, and effectiveness.
Reeb graph of the height function on a planar polygon
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Tereshchenko Vasyl , Prishlyak Oleksandr ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: February 2025

Height functions, which are Morse functions of the general position, are often used when studying the structure of manifolds. The structure of such functions is described using the Reeb graph. On two-dimensional oriented closed manifolds, as well as on compact domains with a smooth boundary, the Reeb graph is a complete topological invariant of a simple Morse function. Its vertices have degree 1 if the vertex corresponds to a local extremum, or 3 if the vertex corresponds to a saddle critical point. For the height function on a polygon, we consider a Reeb graph whose vertices coincide with the vertices of the polygon. In this case, in addition to vertices of degrees 1 and 3, the Reeb graph will also have vertices of degree 2, which correspond to the regular vertices of the polygon. We show that the Reeb graph of a polygon can be constructed in a time no less than O(n log n), which is the best possible for many computational geometry problems. In addition, the Reeb graph can be embedded as a rectilinear graph in a polygon. This allows you to construct a division of a polygon into monotone polygons with their subsequent triangulation. We have also established the connection between the Reeb graph of the polygon and the Reeb graph of the height function on the smoothed axis 3D thickening, which opens up the possibility of using these structures to build the skeleton of 3D models with its further use in computer graphics. We give an example of constructing a Reeb graph using the process of planar sweeping with a straight line and subsequent triangulation of a polygon. The obtained results can also be used to study the properties of Reeb graphs of combinations of polygons in three-dimensional space. It is also promising to find all possible Reeb graphs of polygons with a small number of vertices.
PREDICTORS OF LONELINESS: MEANING IN LIFE, PSYCHOLOGICAL RESILIENCE AND HOPE
Authors: Akyıl Yusuf , Oral Tuncay , Erdinç Beste , Çakır Hazal Yağmur
Published: February 2025

Loneliness is a state that individuals find undesirable and unsettling when there is a discrepancy between the desired relationships they wish to have and the relationships they believe they now possess. This study aims to investigate the predictive role of purpose in life, psychological resilience, and hope in relation to loneliness. The study's sample consisted of 386 female university students who participated voluntarily. The study utilized the "UCLA Loneliness Scale," "Persevering Hope Scale," "Brief Resilience Scale," and "Meaning in Life Scale" to assess the relevant topics. We used correlation analysis to examine the link between the ideas, and conducted multiple regression analysis to determine if purpose in life, psychological resilience, and hope could predict loneliness. The findings indicated substantial inverse associations between loneliness and purpose in life, psychological resilience, and hope. Moreover, these independent variables significantly predicted loneliness. We analyzed and examined the collected findings in relation to the pertinent literature. To mitigate the adverse effects of loneliness, it is possible to bolster psychological resilience, conduct research on existential meaning, and implement programs aimed at fostering hope.
Intro to special issue
Authors: Luka Mary Elizabeth , Nelson Robin , Newman Shawn , Sokoloski Robin
Published: February 2025

In the first of this double issue, we grounded the collection in Mass Culture’s Research in Residence: Arts’ Civic Impact (RinR) project. Aimed at creating a suite of impact measurement frameworks for arts organizations to assess where and how their work has impact, the SSHRC- and Mitacs-funded project embedded four individual graduate student researchers and one team of two graduate students—all from different post-secondary institutions—in arts organizations across the country. Also supported by a group of arts funders comprising an advisory, this first-of-its-kind initiative has had impressive impacts of its own in both the academic and culture sector spheres. Since publishing our first collection of articles, the landscape has changed. RinR’s graduate student researchers have all moved on in some way, be it finishing a master’s degree and starting a doctorate, finishing a doctorate and moving into a post-doctoral fellowship, finishing graduate school and working within an academic institution, and even continuing with their studies while starting a family. Other people involved in RinR have likewise changed jobs or even left the arts sector or academia altogether. Assembling this second issue has afforded us, the co-editors, some very welcome reflection on the project, the relationships we built through it, and how it continues to shape both our individual careers and perspectives on the arts’ civic impact.
Reflections on the 2021-2022 Arts’ Civic Impact Project
Authors: Richmond Aaron
Published: February 2025

In this article, Aaron Richmond develops the foundations for an evaluation framework that has the potential to impact how notions of embodied accessibility in creative performance will work in the near future. Richmond focuses on the specificity of discourse and decision-making that enables the inclusion of various audiences, choreographers, and performers in the field of dance. In the process, Richmond thinks through a series of questions grounded in a field of study that first emerged upon noticing several recent Montreal-based dance projects aimed at making dance accessible for blind and low-vision communities. These questions include: What does accessibility look like when it doesn’t look like anything? When, above all, it cannot be imagined as an interface of constraints neatly lifted and boxes suitably checked? What is an accessibility that accepts and defends the functional gains of earlier activists, while also setting new horizons for disability justice⁠? Conducted between 2021-2023, this investigation enquires deeply into the discourses circulating around and through the actual production processes being observed. More specifically, the research brings critical disability studies into conversation with current forms of expression on the stage in more nuanced ways than have been previously investigated. What results is a framework that Richmond names Access in Counterpoint. The framework consists of five pairs of terms - each pair introducing a particular set of questions for those working in the field of accessible dance, and aiming to understand their own investment in impact, defined broadly. At first glance, these terms could be thought of as binaries or opposites, but as Richmond demonstrates in the concluding section of the article, these contrasting terms begin to trace out a spectrum of possibility: a way of thinking while doing in the field, in design, in development, in performance, and upon reflection.
Threads That Become Tendrils
Authors: Bernicky Shanice
Published: February 2025

The settler-state of Canada continues to reconcile with the genocide of the original Indigenous custodians of the lands on which we operate, alongside the underserving and discriminating against racialized, black, disabled, and LGBTQ2+ peoples all while navigating a climate crisis, the proliferation of equity, diversity, and inclusion (EDI) nomenclature and plans permeates every social and financial sector. EDI initiatives, while called many names throughout history such as social inclusion and affirmative action, experienced a rise in creation in 2020 because of public outcries for the acknowledgement of systemic racial injustice and pressure to address this ongoing form of violence. Canada’s arts and culture sector is not immune from this scrutiny. Having a long history of engaging in social services, the arts and culture sector is often tasked with “fixing” issues when funding is cut to education, health, and community programs, yet arts institutions are not equipped to do this. This paper follows one resident researcher’s journey as they were tasked with developing an arts civic impact framework suggesting equity practices in the arts. The study used a mixed-methods approach, drawing from the walking interview, reverse photo-elicitation, feminist manifestos and research-creation to bring cultural workers across the country together to develop an accessible tool to carefully engage in equity practices within the sector. As a critique and response to flat and prescriptive EDI plans, what was created based on this cross-country collaboration was a non-linear, spiraling framework existing online that arts organizations can make use of and adapt based on their circumstances. Weaving together a historical account of arts administration, Western managerialism, and the EDI in the arts sector, this article responds to the research question: How can access to the arts and culture sector from coast-to-coast-to-coast be more equitable?
Indigenous Ways Infiltrating the Research Realm
Authors: Pascal Sydney
Published: February 2025

The summer of 2021 was the beginning of my experience as a researcher from Emily Carr University of Art & Design on a project that connected me with other researchers across Canada. The project was titled Research in Residence: Arts’ Civic Impact, and was an initiative in collaboration with Mass Culture, the Canada Council for the Arts, the Culture Statistics Working Group, the Ontario Trillium Foundation, and the Toronto Arts Foundation. Each researcher had their own area of interest, with my focus being on researching and exploring the innovative ways of reframing research methods and connecting with communities in the arts sector and academic institutions to align with methods derived from an Indigenous way of gathering information.