bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology and survival outcomes of patients with primary intraocular lymphoma: a population-based analysis
Authors: He Lin-feng , Zhang Jin-di , Chen Xin-xin , Wei Rui-li
Published: December 2022

Background

Primary intraocular lymphoma (PIOL) is a rare malignancy with a poor prognosis, but its optimal therapy remains unclear. Herein, we aimed to analyze the epidemiology and survival outcomes of PIOL patients based on a population-based cancer registry in the United States.

Methods

Patients diagnosed with PIOL between 1992 and 2018 were identified from the Surveillance Epidemiology and End Results program. The patients were divided into two groups: those aged < 60 years and ≥ 60 years. We used the chi-squared test to analyze the differences between the two groups. Descriptive analyses were performed to analyze epidemiological characteristics and treatment. The likely prognostic factors were analyzed by Kaplan–Meier curves and Cox proportional hazards models.

Results

The overall incidence of PIOL was 0.23/1,000,000, which was steadily increasing from 1992 to 2018, with an annual percentage change of 2.35. In total, 326 patients (mean age, 66.1 years) with PIOL were included in this study, 72.1% were aged ≥ 60 years, 84.4% were White, and 60.4% were female. The most common pathological type was diffuse large B-cell lymphoma (DLBCL), but in patients aged < 60 years, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue was the most common. The disease-specific survival rates were 74.2% and 61.5% 5 and 10 years after diagnosis, respectively. Survival analysis found that surgery, radiation, and chemotherapy did not lead to better prognosis.

Conclusions

PIOL is a rare disease with poor prognosis, and its incidence has been increasing for nearly 30 years. It usually affects people aged ≥ 60 years, and DLBCL is the most common pathological type of PIOL. Patients aged < 60 years and with non-DLBCL type have improved survival. Survival of PIOL has improved in recent years.
Association of daytime napping frequency and schizophrenia: a bidirectional two-sample Mendelian randomization study
Authors: Ma Jun , Jin Chen , Yang Yan , Li Haoqi , Wang Yi
Published: December 2022

Background

The bidirectional causal association between daytime napping frequency and schizophrenia is unclear.

Methods

A bidirectional two-sample Mendelian randomization (MR) analysis was conducted with summary statistics of top genetic variants associated with daytime napping frequency and schizophrenia from genome-wide association studies (GWAS). The single nucleotide polymorphisms (SNPs) data of daytime napping frequency GWAS came from the UK Biobank (n = 452,633) and 23andMe study cohort (n = 541,333), while the schizophrenia GWAS came from the Psychiatric Genomics Consortium (PGC, 36,989 cases and 113,075 controls). The inverse variance weighted (IVW) analysis was the primary method, with the weighted median, MR-Robust Adjusted Profile Score (RAPS), Radial MR and MR-Pleiotropy Residual Sum Outlier (PRESSO) as sensitivity analysis.

Results

The MR analysis showed a bidirectional causal relationship between more frequent daytime napping and the occurrence of schizophrenia, with the odds ratio (OR) for one-unit increase in napping category (never, sometimes, usually) on schizophrenia was 3.38 (95% confidence interval [CI]: 2.02–5.65, P = 3.58 × 10–6), and the beta for the occurrence of schizophrenia on daytime napping frequency was 0.0112 (95%CI: 0.0060–0.0163, P = 2.04 × 10–5). The sensitivity analysis obtained the same conclusions.

Conclusion

Our findings support the bidirectional causal association between more daytime napping frequency and schizophrenia, implying that daytime napping frequency is a potential intervention for the progression and treatment of schizophrenia.
Violations of the International Code of Marketing of Breast-milk Substitutes: a multi-country analysis
Authors: Lutter C. K. , Hernández-Cordero S. , Grummer-Strawn L. , Lara-Mejía V. , Lozada-Tequeanes A. L.
Published: December 2022

The marketing of formula milk as a substitute for breast milk continues to be ubiquitous and multifaceted despite passage by the World Health Assembly of the International Code of Marketing of Breast-milk Substitutes (the Code) in 1981. In this paper, we summarized reports of the Code violations from eight studies using the WHO/UNICEF NetCode protocol. Among 3,124 pregnant women and mothers with young children, in eight countries, 64% reported exposure to promotion of products covered under the Code in the previous 6 months, primarily from advertisements seen outside of health facilities (62%). Nearly 20% of mothers with an infant < 6 months reported that a health care provider had advised them to feed their child food or drink other than breast milk, and 21% of providers reported contact with a representative of a formula company in the previous 6 months to distribute promotional materials, samples, or free supplies (range 2%–53%). Of the 389 retail stores and pharmacies surveyed, promotions were observed in 63% (range 0–100%), and of 1,206 labels and inserts of products reviewed, nearly half included health and/or nutrition claims (range 0–100%). A strong, though non-significant, linear relationship between the composite violations score and quality of Code legislation was found; countries with the lowest percentage of violations had the strongest Code legislation. In Latin America, over 50% of health care providers reported no knowledge of the Code, and 50% reported no knowledge of national legislation. Our study highlights three key facts: 1) the marketing of BMS is ubiquitous and multifaceted, 2) the high variability of promotion across countries generally reflects the comprehensiveness of Code legislation, and 3) health care providers have poor knowledge of the Code and national legislation.
Impact of the COVID-19 pandemic on cardiology fellow echocardiography education at a large academic center
Authors: Varghese Merilyn S. , Strom Jordan B. , Kannam Joseph P. , Fostello Sarah E. , Riley Marilyn F. , Manning Warren J.
Published: December 2022

Background

In response to COVID-19 pandemic state restrictions, our institution deferred elective procedures from 3/15/2020 to 6/13/2020, and removed cardiology fellows from the echocardiography rotation to staff clinical services. We assessed the impact of the COVID-19 pandemic on fellow education and echocardiography volumes.

Methods

Our institutional database was used to examine volumes of transthoracic (TTE), stress (SE), and transesophageal echocardiograms (TEE) from 7/1/2018 to 10/10/2020. Study volumes were compared in three intervals: pre-pandemic (7/1/2018- 3/14/2020), pandemic (3/15/2020–6/13/2020), and pandemic recovery (6/14/2020–10/10/2020). We examined weekly number of TTEs performed or interpreted by cardiology fellows during the study period, and compared these to the two previous academic years.

Results

Weekly TTE volume declined by 54% during the pandemic, and increased by 99% during pandemic recovery, (p < 0.05). SE and TEE revealed similar trends. A strong correlation between weekly TTE volume and inpatient admissions was observed during the study period (rs=0.67, p < 0.05). Weekly fellow TTE scans declined by 78% during the pandemic, with a 380% increase during pandemic recovery (p < 0.05). Weekly fellow TTE interpretations declined by 56% during the pandemic, with a 76% increase during pandemic recovery (p < 0.05).

Conclusion

COVID restrictions between 3/15/2020- 6/14/2020 coincided with a marked decline in TTE, SE, and TEE volumes, with an increase similar to near pre-pandemic volumes during the pandemic recovery period. A similar decline with the onset of COVID restrictions, and increase to pre-restriction volumes thereafter was observed with fellow scans and interpretations, but total academic year fellow training volumes remained depressed. With the ongoing COVID-19 pandemic and rise of multiple variants, training programs may need to adjust fellows’ clinical responsibilities so as to support achievement of echocardiography training certification.
The association between time in the glucose target range and abnormal ankle-brachial index: a cross-sectional analysis
Authors: Wei Yinghua , Liu Chunyan , Liu Yanyu , Zhang Zhen , Feng Zhouqin , Yang Xinyi , Liu Juan , Lei Haiyan , Zhou Hui , Shen Qiuyue , Lu Bin , Gu Ping , Shao Jiaqing
Published: December 2022

Background

Time in range (TIR), a novel proxy measure of glucose control, is found closely related to diabetic microangiopathy and some other chronic complications, but the correlation between TIR and lower limb angiopathy has not been studied yet. Our purpose is to explore the relationship between TIR and abnormal ankle-brachial index(ABI) in type 2 diabetes.

Methods

We retrospectively collected patients’ information from the database and performed cross-sectional analysis. A total of 405 type 2 diabetes patients were enrolled in this study. ABI was measured and patients were stratified into low, normal, and high groups according to ≤ 0.9, > 0.9 and < 1.3, ≥ 1.3 ABI values. All patients underwent continuous glucose monitoring(CGM), and TIR was defined as the percentage of time in which glucose was in the range of 3.9–10 mmol/L during a 24-h period. Correlations between TIR and abnormal ABI were analyzed using Spearman analysis. And logistic regression was used to explore whether TIR is an independent risk factor for abnormal ABI.

Results

The overall prevalence of abnormal ABI was 20.2% (low 4.9% and high 15.3%). TIR was lower in patients with abnormal ABI values (P = 0.009). The prevalence of abnormal ABI decreased with increasing quartiles of TIR (P = 0.026). Abnormal ABI was negatively correlated with TIR and positively correlated with hypertension, age, diabetes duration, UREA, Scr, ACR, TAR, MBG, and M values (P < 0.05). The logistic regression revealed a significant association between TIR and abnormal ABI, while HbA1C and blood glucose variability measures had no explicit correlation with abnormal ABI. Additionally, there was a significant difference in LDL between the low and high ABI groups (P = 0.009), and in Scr between normal and low groups (P = 0.007). And there were significant differences in TIR (P = 0.003), age (P = 0.023), UREA (P = 0.006), ACR (P = 0.004), TAR (P = 0.015), and MBG (P = 0.014) between normal and high ABI groups, and in diabetes duration between both normal and low (P = 0.023) and normal and high (P = 0.006) groups.

Conclusions

In type 2 diabetes patients, abnormal ABI is associated with lower TIR, and the correlation is stronger than that with HbA1C. Therefore, the role of TIR should be emphasized in the evaluation of lower limb vascular diseases.
Impact of COVID-19 pandemic on antifungal consumption: a multicenter retrospective analysis
Authors: Bienvenu Anne-Lise , Bestion Audrey , Pradat Pierre , Richard Jean-Christophe , Argaud Laurent , Guichon Céline , Roux Sandrine , Piriou Vincent , Paillet Carole , Leboucher Gilles ,   the Antifungal study group, Ader Florence , Aubrun Frédéric , Besson Charlotte , Bréant Valentine , Doudet Charlotte , Ducastelle-Leprêtre Sophie , Dupont Damien , Guillemin Marie-Delphine , Leray Véronique , Miossec Charline , Paulus Sylvie , Rabain Anne-Marie , Rascle Pauline , Schulz Thomas , Tod Michel , Valour Florent , Wallet Florent , Wallon Martine
Published: December 2022

Background

In the context of COVID-19 pandemic, antifungal overuse may have occurred in our hospitals as it has been previously reported for antibacterials.

Methods

To investigate the impact of COVID-19 on antifungal consumption, a multicenter retrospective study including four medical sites and 14 intensive care units (ICU) was performed. Antifungal consumption and incidences of invasive fungal diseases before and during COVID-19 pandemic, for non-COVID-19 patients and COVID-19 patients, were described.

Results

An increase in voriconazole consumption was observed in 2020 compared with 2019 for both the whole hospital and the ICU (+ 40.3% and + 63.7%, respectively), whereas the incidence of invasive aspergillosis significantly increased in slightly lower proportions in the ICU (+ 46%). Caspofungin consumption also increased in 2020 compared to 2019 for both the whole hospital and the ICU (+ 34.9% and + 17.0%, respectively) with an increased incidence of invasive candidiasis in the whole hospital and the ICU but in lower proportions (+ 20.0% and + 10.9%, respectively).

Conclusions

We observed an increased consumption of antifungals including voriconazole and caspofungin in our hospital during the COVID-19 pandemic and explained in part by an increased incidence of invasive fungal diseases in COVID-19 patients. These results are of utmost importance as it raises concern about the urgent need for appropriate antifungal stewardship activities to control antifungal consumption.
Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations
Authors: Yuan Shuai , Chen Jie , Ruan Xixian , Vithayathil Mathew , Kar Siddhartha , Li Xue , Mason Amy M. , Burgess Stephen , Larsson Susanna C.
Published: December 2022

Background

The associations of rheumatoid arthritis (RA) with risk of site-specific cancers beyond lymphohematopoietic cancer have been scarcely explored. We conducted a Mendelian randomization investigation of the associations of RA with site-specific cancers in European and East Asian populations.

Methods

Independent genetic variants strongly associated with RA in European and East Asian populations were selected as instrumental variables from genome-wide association studies of 58,284 European individuals (14,361 cases and 43,923 controls) and 22,515 East Asian individuals (4873 cases and 17,642 controls), respectively. The associations of genetic variants with overall and 22 site-specific cancers were extracted from the UK Biobank study (n = 367,561), the FinnGen study (n = 260,405), Biobank Japan (n = 212,453), and international consortia. The associations for one outcome from different data sources were combined by meta-analysis.

Results

In the European population, the combined odds ratios per 1-unit increase in log odds of genetic liability to RA were 1.06 (95% confidence interval [CI] 1.03–1.10) for head and neck cancer, 1.06 (95% CI 1.02–1.10) for cervical cancer, 0.92 (95% CI 0.87–0.96) for testicular cancer, and 0.94 (95% CI 0.90–0.98) for multiple myeloma. In the East Asian population, the corresponding odds ratios were 1.17 (95% CI 1.06–1.29) for pancreatic cancer, 0.91 (95% CI 0.88–0.94) for breast cancer, and 0.90 (95% CI 0.84–0.96) for ovarian cancer. There were suggestive associations for breast and ovarian cancer and overall cancer in the European population. No other associations were observed.

Conclusion

This study suggests that RA may play a role in the development of several site-specific cancers.
Sphaeranthus indicus Linn ameliorates streptozotocin-induced experimental diabetic neuropathy by targeting oxidative stress-mediated alterations
Authors: Jadhav Vishal B. , Vaghela Jai Singh
Published: December 2022

Background

Diabetes-induced neuropathic pain is manifested as a lowering of nerve transmission rate, increased discomfort, sensual loss, and axonal degradation, and is the most prevalent secondary consequence of diabetes. Diabetes is a devitalizing disease affecting people from diverse groups in both developing and industrialized countries. The inflammation pathway and oxidative stress both contribute considerably to diabetic peripheral neuropathy via the activation of inflammatory cytokines. Hyperglycemia-mediated neural oxidative stress and damage activates a number of metabolic pathways, causing diabetic neuropathy. The current study investigated the neuroprotective potential of methanolic extract of Sphaeranthus indicus Linn (MESI) in ameliorating diabetic neuropathic pain induced by administration of streptozotocin in rats.

Results

Four weeks after intraperitoneal treatment of streptozotocin (STZ), there was a significant decrease in mechano-tactile allodynia and mechanical and thermal hyperalgesia. Furthermore, STZ-induced oxidative stress increases the extent of neural lipid peroxidation (LPO), as evidenced by increased MDA levels, decreases the activities of endogenous antioxidants such as superoxide dismutase (SOD) and glutathione (GSH), and alters sciatic neural histoarchitecture. Chronic administration of methanolic extract of Sphaeranthus indicus Linn (MESI) for 4 weeks significantly and dose-dependently attenuated the decrease in levels of nociceptive thresholds, endogenous antioxidants (SOD and GSH), and increase in LPO. Furthermore, MESI significantly restored sciatic neural histoarchitecture.

Conclusion

The amelioration of streptozotocin-induced diabetic neuropathy by methanolic extract of Sphaeranthus indicus Linn (MESI) could be attributed to its antinociceptive, antioxidant, and neuroprotective properties.
Predictive factors for recovery in idiopathic sudden sensory neural hearing loss
Authors: Alhussaini Mohamed A. , Mohamed Suhaib Abdelzaker , El-Razek Mohamad Azzam Abd , Mohamed Enass Sayed , Gad Mohamed Omar A.
Published: December 2022

Background

Idiopathic sudden sensorineural hearing loss (ISSNHL) is considered a clinical symptom of various conditions. Circulatory disorders, viral infection, labyrinthine membrane rupture, and autoimmune reactions are considered as the common causes, but the exact cause remains unestablished. Various drugs and methods have been used empirically for the treatment of ISSHL. The current study aimed at evaluation factors contributing to the success of standardized medical therapy in cases of ISSNHL.

Methods

In period between 2019 and 2021, a total 40 patients with ISSNHL were enrolled. All patients were subjected to history taking, physical and ENT evaluation. Patients were managed according to the recent guidelines for managing ISSNHL included systemic steroid and salvage therapy.

Results

Mean age of studied patients was 42.55 ± 13.14 years with range between 19 and 70 years. Out of the studied patients; 26 (65%) patients were males and 14 (35%) patients were females. Majority (80%) of patients had no comorbidities. Based on the current study, we found that only 12 (30%) patients were improved while 28 (70%) patients were not improved. It was found that majority (58.3%) of improved patients was females. Frequency of vertigo was significantly higher among patients who were not improved. Three (10.7%) patients of not-improved group and 5 (41.7%) patients of improved group had low lymphocyte:monocytes ratio.

Conclusion

Patients with ISSNHL, the presence of vertigo and late onset of presentation may carry a risk for poor prognosis. Multiple centers studies with large number of patients are warranted to confirm such findings.
Static analysis of box-girder bridge under the influence of Indian railway vehicle loading using ANSYS finite element model
Authors: Shaikh Mohammad Farhan , Nallasivam K.
Published: December 2022

The box-girder bridge has recently gained a lot of popularity because of its serviceability, stability, and structural efficiency. The box-girder bridge also has a lower structural weight than any other type of bridge. However, the analysis of such a bridge is too complex and challenging for the designers. This paper offers a modelling process for the study of a box- girder bridge with a ballastless sub-track system using the finite element method and evaluates the different static response characteristics of the bridge when it is loaded according to Indian Railway standards. The modelling and the evaluation of the 3D model of the bridge have been done using non-closed form finite element method (FEM) based ANSYS software and loadings have been applied symmetrically and un- symmetrically. Static analysis is carried out. The model has been simulated, and the resultants of deflection and stresses have been determined, taking into account the effect of different combinations of loading from the Indian Railways. The present modelling process is applied to analyze the box-girder bridge for 5 spans of 32 m each. For analysis of any box-girder bridge, though, researchers can use the modelling process described above.
Bone Turnover Markers: Basic Biology to Clinical Applications
Authors: Schini Marian , Vilaca Tatiane , Gossiel Fatma , Salam Syazrah , Eastell Richard
Published: December 2022

Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation markers (bone alkaline phosphatase, osteocalcin, and procollagen I N-propeptide); and commonly used resorption markers (serum C-telopeptides of type I collagen, urinary N-telopeptides of type I collagen, and tartrate-resistant acid phosphatase type 5b). BTMs are usually measured by enzyme-linked immunosorbent assay or automated immunoassay. Sources contributing to BTM variability include uncontrollable factors (eg, age, gender, ethnicity) and controllable factors, particularly relating to collection conditions (eg, fasting/feeding state, and timing relative to circadian rhythms, menstrual cycling, and exercise). Pregnancy, season, drugs, and recent fracture(s) can also affect BTMs. BTMs correlate with other methods of assessing bone turnover, such as bone biopsies and radiotracer kinetics, and can usefully contribute to diagnosis and management of several diseases such as osteoporosis, osteomalacia, Paget’s disease, fibrous dysplasia, hypophosphatasia, primary hyperparathyroidism, and chronic kidney disease–mineral bone disorder.
Frequency-dependent viscosity of salmon ovarian fluid has biophysical implications for sperm–egg interactions
Authors: Graziano Marco , Palit Swomitra , Yethiraj Anand , Immler Simone , Gage Matthew J. G. , Purchase Craig F.
Published: December 2022

Gamete-level sexual selection of externally fertilising species is usually achieved by modifying sperm behaviour with mechanisms that alter the chemical environment in which gametes perform. In fish, this can be accomplished through the ovarian fluid, a substance released with the eggs at spawning. While the biochemical effects of ovarian fluid in relation to sperm energetics have been investigated, the influence of the physical environment in which sperm compete remains poorly explored. Our objective was therefore to gain insights on the physical structure of this fluid and potential impacts on reproduction. Using soft-matter physics approaches of steady-state and oscillatory viscosity measurements, we subjected wild Atlantic salmon ovarian fluids to variable shear stresses and frequencies resembling those exerted by sperm swimming through the fluid near eggs. We show that this fluid, which in its relaxed state is a gel-like substance, displays a non-Newtonian viscoelastic and shear-thinning profile, where the viscosity decreases with increasing shear rates. We concurrently find that this fluid obeys the Cox–Merz rule below 7.6 Hz and infringes it above this level, thus indicating a shear-thickening phase where viscosity increases provided it is probed gently enough. This suggests the presence of a unique frequency-dependent structural network with relevant implications for sperm energetics and fertilisation dynamics.

This article has an associated ECR Spotlight interview with Marco Graziano.
Accountability: O estudo de sua aplicação a partir da Constituição da República de 1988 e da jurisprudência do Supremo Tribunal Federal
Authors: Oliveira Fábio Cesar dos Santos
Published: December 2022

O artigo examina os fundamentos teóricos da accountability e sua aplicação no direito brasileiro com base na interpretação de dispositivos da Constituição da República de 1988 observada em julgados do Supremo Tribunal Federal. A investigação parte da pergunta se a ausência de referência ou tradução do termo accountability no texto constitucional de 1988 seria fundamento para deixar de reconhecer sua aplicação no direito brasileiro. A pesquisa de jurisprudência foi a metodologia empregada, a qual, em conjunto com a revisão bibliográfica sobre o tema, teve como baliza os acórdãos prolatados entre 5 de outubro de 1988 e 31 de outubro de 2021, obtidos com o uso da palavra accountability como critério de busca no banco de dados disponível no sítio eletrônico do Supremo Tribunal Federal. A amostra é formada pelos julgados em que houve menção expressa a accountability, para verificar se o Tribunal a reconhece como norma constitucional e em quais hipóteses sua aplicação é mais frequente. As conclusões principais são: a ausência de enunciação expressa de disposição congênere, em língua portuguesa, na Constituição da República de 1988, não impede que a accountability tenha hierarquia constitucional, por ser um desdobramento da cláusula do estado democrático de direito, sob o regime republicano; e o Supremo Tribunal Federal refere-se a accountability para reiterar o dever de publicidade da administração pública e reforçar os mecanismos já existentes para promoção de controle de seus atos. A jurisprudência da Corte ainda não se vale da accountability para medir o grau de eficiência dos serviços públicos prestados e dos instrumentos de controle disponíveis.
Scoping review on population pharmacokinetics of vancomycin in non-critically ill
Authors: Nivia Diego , Vivas Juan-David , Briceño Wilson , Parra Daniel , Jaimes Diego , Bustos Rosa Helena
Published: December 2022

Background: Vancomycin is an effective first-line therapy in MRSA infection, however, achieving an appropriate serum concentration is challenging. Population pharmacokinetics can assist the clinician in the selection of better regimen dosing and improve effectiveness and safety outcomes. Methods: This scoping review aims to outline the evidence in population pharmacokinetic models in non-critical adults hospitalized from 1980 to 2021 and describe the principal software and covariables used in this. A total of 209 papers were fully screened. Finally, we included 17 articles conducted in different locations around the world. Results: This review identified 13 retrospective articles and 4 prospective, 5 describing the use in a general population with gram-positive bacterial infection, 11 evaluated special populations (older, obese, and cancer patients), and 1 mixed population. The main parameters in the models were renal clearance and volume of distribution. The principal covariables that affected the models were creatinine clearance and weight. All studies use internal validation methods, and three of them used an external validation group. This scoping review highlights the principal information of different population pharmacokinetic models and the heterogeneity in the parameters and methods of evaluation. Conclusions: These methods can be used to guide the dosing regimen in different subpopulations. However, it is imperative to define the best fit in every population and conduct an experiment due to the high variability in the present studies.
Modeling of options for the development of a fire at an object of mass stay of people
Authors: Sazonova Svetlana , Zyazina Tat'yana , Goryunov Vasiliy
Published: December 2022

The operational-tactical characteristics of the object of mass stay of people of the Municipality of the Cinema and Concert Hall "October" in Lipetsk are considered. The layout of the object of protection, the existing external and internal fire-fighting water supply are given. The calculation of forces and means for extinguishing a fire in the auditorium on the first floor of the facility, as well as in the control room on the second floor, was carried out. It is noted that, based on the practice of extinguishing fires, the most effective fire extinguishing agents in enclosed spaces are water and foam. A diagram of the possible development of a fire is shown in the figure. The calculation of the required number of barrels, vehicles and the number of personnel for extinguishing and protecting the premises of the object under consideration was carried out. A diagram of the deployment of fire departments on the ground to extinguish a fire in the auditorium of this object is given. The organization of communication during fire extinguishing is considered. Based on the calculations performed, it was concluded that there are enough forces and means to extinguish these fires according to the first or second options for the development of a possible fire, it is not necessary to attract additional forces and means for the second fire rank.
Critical Analysis of the Legal Regulation of Assisted Reproductive Techniques and Biomedical Research in the Slovak Republic in the Context of Natural Law
Authors: Čunderlík Čerbová Veronika
Published: December 2022

The study critically analyses the Slovak legal regulation of assisted reproductive techniques and biomedical research through the prism of natural law attributes. The study confirms the hypothesis that the legal regulation of assisted reproductive techniques and biomedical research in the Slovak Republic is insufficient, does not reflect the actual practice, and allows interpretations and application that are not in line with natural law. The identified shortcomings do not correspond to the fact that the Slovak Republic is one of the countries with a restrictive biopolitics. The study demonstrates that even in the case of conservative legislation, the natural-law basis can be undermined or denied if the legislation does not sufficiently reflect all contexts. For comparison, we present selected legislation from the Czech Republic, which is more precise and consistent, although more liberal. The study also contains specific de lege ferenda proposals that are based on natural law foundations and at least partially remedy the identified shortcomings.
Participation in Public Religious Practices During the COVID-19 Pandemic. Between Various Limitations and Their Proportionality
Authors: Skoczylas Łukasz , Piątek Wojciech
Published: December 2022

The right to manifest religion or belief in community with others is one of the essential components of religious freedom. However, it has been significantly curtailed in many countries owing to the Covid-19 pandemic. This article identifies the scope of the introduced restrictions, their proportionality, and their impact on the functioning of religious communities. Section 1 sets out three different approaches to participation in public religious practices in selected countries with severe (Germany), moderate (Poland), and liberal (Belarus) restrictions. In section 2, an international perspective on access to religious buildings in times of emergency is presented. The conclusions of this research are juxtaposed in section 3 with the jurisprudence of the highest national courts in Germany, the United States, and France, in order to highlight proportional legal solutions for the protection of religious freedom and public health. In the last section, the consequences of the introduced restrictions are analysed from the perspective of religious associations, using the example of Poland. Lastly, predictions concerning future participation in religious services are also made.
Issues on Water Privatization Under New Regulation: Evidence in Indonesia
Authors: Hermawan Sapto , Hananto Supid Arso
Published: December 2022

Water plays a vital role in every human life, so the availability and sustainability of water resources need to be carefully regulated. This article attempts to analyse water governance in Indonesia under the new water resources regulation, mainly the issue of water privatization. This article is classified as normative legal research. This article shows that even though the State gives the water privatization licence to the private sector as the last priority, it seems that the Indonesian people will still encounter the same problem in the coming year. This article argues that the issue of distribution of water justice, water access, and violations of the water right related to water utilization on a large scale are challenges for the Indonesian government to resolve.
The European Dimension to the Constitution of the Republic of Italy
Authors: Mangione Gariella
Published: December 2022

Italy was one of the countries that signed the Treaty of Rome in 1957, which created the European Economic Community. Despite initial resistance and the numerous difficulties encountered during subsequent years, the choice to commit to Europe was widely shared, becoming irreversibly embedded in the national consciousness. However, whilst other legal systems chose at various stages of their European journey to amend their constitutions by incorporating a European clause, this never happened in Italy. Italy did not change its Constitution as a result of joining the European Economic Community, and has not done so subsequently after becoming part of the European Union with the Maastricht Treaty, following the adoption of the Treaty of Lisbon, nor indeed at any subsequent stage in the process of European integration. It was only in 2001, with the reform of Title V of the Constitution involving changes in the allocation of powers between the state, the regions, and the local authorities, that the expression “Community law” was incorporated into the Constitution. Given the absence of a European clause, the relationship between the Italian Constitution and Europe has been shaped by the Constitutional Court. First and foremost, it interpreted Article 11 of the Constitution, which lays down a generic clause intended to enable the exercise of sovereign powers by international organizations, in such a manner as to bring the European project within its scope. The Constitutional Court developed its case law in its subsequent decisions, even though progress was at times hardfought, and in some cases marked by contradictions; Italy’s cohabitation with Europe was undoubtedly welcome, but this did not mean that it was painless.
A note on local minimizers of energy on complete manifolds
Authors: Batista Márcio , Santos José I.
Published: December 2022

In this paper, we study the geometric rigidity of complete Riemannian manifolds admitting local minimizers of energy functionals.
More precisely, assuming the existence of a non-trivial local minimizer and under suitable assumptions, a Riemannian manifold under consideration must be
a product manifold furnished with a warped metric.
Secondly, under similar hypotheses, we deduce a geometrical splitting in
the same fashion as in the Cheeger-Gromoll splitting theorem and we also get information about local minimizers.
IMPACT OF EARNINGS AND DEBT INFORMATION ON INVESTOR BEHAVIOR
Authors: Adi Sunu Prasetya , Addury Multazam Mansyur
Published: December 2022

Information from company publications can be an initial signal for investors to buy shares in the company. The earnings information can be an indicator for investors to assess and predict profits for companies and investors in the future. This study aims to analyze the impact of earnings and debt information on investor behavior in buying shares. This study uses the LQ45 company object on the Indonesia Stock Exchange. The data used in the form of annual from 2014 to 2018. Research data analysis techniques used are descriptive analysis and panel data regression. The results found that the earnings information variable measured by net profit has a positive and significant effect on investor behavior as measured by the company's sales volume at a significance level of 5%. The debt information variable measured by DER has no significant effect on investor behavior as measured by the company's sales volume.
CULTURE AS SOLUTION FOR ENTREPRENEUR IN AMBON WHILE COVID-19 PANDEMIC
Authors: Marasabessy Andi Ismail
Published: December 2022

This research was conducted to find out how food and beverage entrepreneurs survive during the Covid-19 pandemic. This study used a qualitative approach with the research subject being a beverage entrepreneur or a shop in Ambon city. The results showed that the culture of Ambonese people gathering really helped coffee shop businesses in Ambon city to survive during the Covid-19 pandemic. In addition, it was also found that many new coffee shops were started even though the Covid-19 pandemic was increasingly worrying. The habit of Ambonese people to meet and tell stories has a very positive impact on shop or beverage entrepreneurs to survive during the Covid-19 pandemic. Other results also show that government assistance has provided assistance for shopkeepers to survive during the Covid-19 pandemic.
New records of Sturnira bakeri in northwestern Ecuador: field notes about the species
Authors: Rodriguez-Segovia Marco A.
Published: December 2022

A pesar de que Sturnira bakeri es una especie descrita recientemente, se sabe poco sobre su variación intraespecífica, hábitos de alimentación y vuelo, y patrones reproductivos.  Esta investigación tuvo como objetivo confirmar la presencia de esta especie en el noroccidente de Ecuador mediante la comparación de especímenes voucher con la literatura disponible.  Varios ejemplares de S. bakeri fueron capturados en el noroccidente de Pichincha.  Recolecté 2 vouchers, pero me enfoqué en un espécimen variable (un espécimen con algunas características diferentes) y lo comparé con la descripción original de la especie.  Se incluyen notas de campo sobre su apariencia física, estado reproductivo y otros hábitos.  La presencia de S. bakeri en el noroccidente de Ecuador se confirmó por características cráneo-dentales (como la presencia de incisivos internos superiores bicúspides, cúspides internas aserradas en los molares inferiores, fisura esfenorbital ovalada, fosas basiesfenoideas poco profundas y divididas por un septo) y medidas similares a estudios previos, pero con algunas diferencias morfológicas como la forma de los arcos cigomáticos.  Sturnira bakeri fue registrada en bosques secundarios y pastizales, vive en simpatría con S. ludovici, y come frutos de varias especies de plantas: Piper, Vismia, Cecropia, Drymonia, Anthurium y Psychotria.  Los especímenes variables complican la identificación taxonómica y la definición de una especie.  Los nuevos registros con datos sobre dieta y hábitos ayudan a llenar vacíos de conocimiento sobre la especie en esta zona del neotrópico.
Seroprevalence of positive cases of hepatitis A, B and C infections among subjects in two riverine communities in Akwa Ibom State, Nigeria
Authors: Udoh Dora I. , Siedoma Baritudor T. , Eyo Aniekan- O. Augusta
Published: December 2022

Background: Hepatitis infections are endemic in many countries. The serological hallmark for these infections is the presence of antibodies and antigens in the bloods of the infected persons. These serological markers give an idea on seropositivity of specific hepatitis.Methodology: This cross sectional- descriptive study was conducted in two riveriancommunities namely; Ikot Abasi, Oron and Uyo (control). Ethical approval and consents were obtained from the State Ministry of Health and volunteers. Three hundred (300) blood samples, 100 samples from each study area were collected and tested for positive cases of HAV, HBV and HCV infections using hepatitis rapid immunoassay and anti-antibodies kits (Acon Diagnostics, USA) respectively. A structured -questionnaires was used to obtained socio-demographic information from participant. Results: The prevalence of positive cases for HAV, HBV and HCV were; 14%, 10% and 6% in Ikot Abasi community, 20%, 14% and 8% from Oron while Uyo recorded 2%, 12% and 6% respectively. The prevalence of HAV infection at the riverine communities was significantly higher than the control (p < 0.05). Children ≤ 10years had higher prevalence of HAV. The prevalence of HBV and HCV at the riverine communities did not differ from the control (p < 0.05). Prevalence based on socio-demographic parameters differed (p < 0.05) in some study areas. Conclusion: Predisposing factors for the transmission of hepatitis A infection abounds in riverine communities. These factors are not responsible for transmission of hepatitis B and C. Proper hygiene, good sexual conduct, vaccination and awareness are encouraged in the study areas.
Metastatic prostate cancer with negative MRI-targeted prostate biopsies: case report
Authors: Diniz Victor S. , Lara Celso M. C. , Damião Ronaldo
Published: December 2022

The present article reports a case of an asymptomatic patient with ascending PSA and suspected rectal examination for prostate cancer, who underwent two MRI-targeted prostate biopsies, both being negative for this neoplasm. PSMA PET/CT revealed secondary bone implant and the biopsy of the metastatic lesion showed prostate adenocarcinoma. Docetaxel-based chemotherapy associated with androgen deprivation was performed. Despite the high accuracy of MRI-targeted prostate biopsy, diagnosis can be occasionally difficult and PSMA PET/CT can help to find distant lesions and aid the diagnosis.
(Neo)fascismo, (pós)fascismo ou (neo)populismo? Um balanço bibliográfico possível de uma calorosa disputa classificatória
Authors: Sahd Fabio Bacila
Published: December 2022

O artigo debate as disputas classificatórias contemporâneas em torno de figuras como Trump, Bolsonaro, Le Pen e afins. Sem pretender esgotar essa discussão demasiado ampla, faz-se aqui um balanço bibliográfico possível, apresentando e interrelacionando algumas interpretações. Começa introduzindo, de forma muito sintética e a partir do “Dicionário de conceitos políticos”, parte da bibliografia que define fascismo e populismo e pensa suas relações. Garantido esse entendimento básico, periodiza-se brevemente a extrema-direita no pós-guerra, apresentando suas tipologias e a atualidade do conceito de fascismo.Então, são apresentadas algumas interpretações que mobilizam um ou outro desses conceitos para definir lideranças e partidos contemporâneos como (neo)fascistas, pós-fascistas ou (neo)populistas. Constata-se que, não há consenso quanto ao uso dos conceitos nem para os casos clássicos nem para os atuais.
O autoritarismo instrumental no pensamento político de Carlos Lacerda (1950-1955)
Authors: Medeiros Fabrício Ferreira de
Published: December 2022

O retorno de Getúlio Vargas à presidência da República, em 1951, reacendeu o conflito político entre diversos grupos em disputa pelo poder, sendo considerado como prelúdio de uma nova ditadura “totalitária” no Brasil, percepção esta que motivou o acirramento do engajamento de jornalistas como Carlos Lacerda. Este artigo testa a aplicabilidade do autoritarismo instrumental na análise de seu pensamento político, questionando em que sentido o autoritarismo poderia ou não servir como meio transitório de instauração de uma ordem liberal-democrática no país. Para tanto, o trabalho se fundamenta na discussão teórica sobre o autoritarismo instrumental, incluindo sua formulação e as críticas que o conceito recebeu posteriormente, e na análise de artigos e editoriais publicados por Lacerda na Tribuna da Imprensa, entre 1950 e 1955.
Novo-Desenvolvimentismo e populismo no estudo do governo de Dilma Rousseff (2011-2016)
Authors: Lemos Amarildo Mendes
Published: December 2022

Pretendemos analisar a aplicação da categoria populismo feita por economistas alinhados ao pensamento novo-desenvolvimentista em suas avaliações da chamada Nova Matriz Econômica (NME) do governo Dilma. Para tanto, analisamos o conceito de populismo presente nas reflexões de Bresser-Pereira (2016) sobre o governo Dilma. Em seguida, verificamos os esforços de Luis Oreiro e Nelson Marconi (2016) para diferenciar novo-desenvolvimentismo do que chamam de social-desenvolvimentismo, que seria produto da aplicação de uma interpretação equivocada do keynesianismo feita pelos governos do PT. Compreendemos que o novo-desenvolvimentismo, ao mobilizar o conceito de populismo, torna-se uma ideologia alheia aos conflitos sócio-políticos e, ao exigir um “governo forte”, contribui para negação da democracia e das demandas das camadas mais baixas da sociedade.
Apresentação - “O Populismo no século XIX: a emergência de novas formas”
Authors: Prado Maria Emilia da Costa
Published: December 2022

Apresentação do Dossiê "O populismo no século XXI: a emergência de novas formas"
O ressurgimento do fascismo no mundo contemporâneo: história, conceito e prospectiva
Authors: Martins Carlos Eduardo
Published: December 2022

Neste artigo analisamos o fascismo, tomando em consideração alguns dos principais debates teóricos, suas formas históricas, sua inserção temporal no sistema-mundo para avançarmos na proposição de uma definição conceitual que seja capaz de articular suas dimensões centrais às conjunturais e contingenciais, apontar suas tendências prospectivas e sua importância como fenômeno do mundo contemporâneo. Abordamos sua relação com o liberalismo e o conservadorismo e as formas que assume no mundo contemporâneo nos Estados Unidos, Europa e na América Latina.
ESTUPRO COLETIVO: possibilidade de aplicação da teoria do domínio do fato?
Authors: Januário Túlio Felippe Xavier
Published: December 2022

A teoria do domínio do fato encontra-se atualmente no centro das discussões doutrinárias da dogmática jurídico-penal. Após sua controversa utilização no julgamento da Ação Penal 470, pelo Supremo Tribunal Federal, popularmente conhecida como “Mensalão”, muitas questões foram levantadas a respeito de sua compatibilidade com o ordenamento jurídico nacional e da necessidade ou não de sua utilização. Recentemente, no inquérito policial que investiga um caso de suposto estupro coletivo ocorrido no Rio de Janeiro, mais uma vez esta teoria teria sido invocada, mas desta vez, para tentar imputar o crime ao chefe do tráfico de drogas local. Assim, o que se pretende com o presente trabalho é analisar o sistema de autoria e participação adotado pelo ordenamento penal brasileiro e sua compatibilidade ou não com a teoria do domínio do fato. Posteriormente, será feita uma análise particular do caso supramencionado, para averiguar a eventual possibilidade de utilização desta teoria.
A “CARNE MAIS BARATA DO MERCADO” : uma análise biopolítica da “cultura do estupro” no Brasil
Authors: Wermuth Maiquel Ângelo Dezordi , Nielsson Joice Graciele
Published: December 2022

O presente artigo objetiva explicitar os elementos que compõem no Brasil atual a denominada “cultura do estupro”, a partir de uma análise crítico-filosófica do que se designará, aqui, de “biopolítica da carne”. O problema que orienta a pesquisa pode ser assim sintetizado: em que medida a expressão “cultura do estupro” se relaciona diretamente à existência de um juízo moral consolidado ao longo dos tempos, fruto de uma ideologia patriarcal que avaliza a cultura do machismo ainda presente em nossa sociedade, e que coloca a mulher como propriedade e objeto de um desejo do homem, sendo que tal concepção distorcida da representação do feminino acaba por legitimar o uso da violência física ou moral, para a satisfação dos instintos sexuais masculinos? Para responder à indagação, o texto encontra-se articulado em duas partes. Na primeira, busca-se (des)velar a expressão “cultura do estupro”, a partir de um conjunto de elementos que a integram, bem como de autores que exploram a temática, analisando-se, também, recentes estatísticas realizadas no país acerca do assunto. Na sequência, busca-se analisar o percurso histórico de constituição das relações patriarcais no Brasil, compreendidas como base e fonte de legitimação da violência sexual perpetrada pelos homens contra as mulheres. Após, busca-se compreender como se dá o controle biopolítico da vida humana, especialmente da vida das mulheres consideradas enquanto “carnes” à disposição do consumo do biopoder patriarcal. Para a concretização da pesquisa, a metodologia de abordagem utilizada foi a fenomenologia hermenêutica.