bluuebunny/crossref_metadata_2025 huggingface dataset:
O projeto de Martin Heidegger em “Ser e Tempo”: objetivos e método
Authors: Pereira Leão João Victor
Published: October 2024

Resumo: Este artigo analisa o projeto apresentado por Martin Heidegger em Ser e Tempo de recolocação da pergunta pelo ser. Ali são estabelecidas duas tarefas prévias: a analítica existencial centrada no Dasein (ente humano), e a destruição da história da ontologia com vistas à superação dos preconceitos metafísicos consolidados na tradição filosófica. Analisar-se-á a justificativa dada por Heidegger para que a reformulação da pergunta pelo sentido do ser em geral comece pela ontologia fundamental do Dasein, bem como os argumentos que indicam a necessidade de destruição da metafísica. Analisaremos também o método proposto por Heidegger para a realização desse projeto, a fenomenologia hermenêutica, e como ela se desdobra em seu fazer prático na análise do ente humano.
Palavras-chave: Analítica Existencial; Destruição da Metafísica; Fenomenologia Hermenêutica
El proyecto de Martin Heidegger en "Ser y Tiempo: objetivos y método"
Resumen: Este artículo analiza el proyecto presentado por Martin Heidegger en Ser y Tiempo para replantear la pregunta fundamental sobre el ser. Se establecen dos tareas previas: la analítica existencial centrada en el Dasein (ente humano) y la destrucción de la historia de la ontología con el objetivo de superar los prejuicios metafísicos arraigados en la tradición filosófica. Se examinará la justificación dada por Heidegger para que la reformulación de la pregunta sobre el ser comience con la ontología fundamental del Dasein, así como los argumentos que señalan la necesidad de la destrucción de la metafísica. También se analizará el método propuesto por Heidegger para llevar a cabo este proyecto, la fenomenología hermenéutica, y cómo se despliega en su aplicación práctica en el análisis del ente humano.
Keywords: Análisis Existencial; Destrucción de la Metafísica; Fenomenología Hermenéutica
 
Data de registro: 15/01/2024
Data de aceite: 09/07/2024
Procesos participativos, relaciones vecinales y diversidad sociocultural. Un análisis crítico en dos barrios de Valencia
Authors: Mompó Eva , Torres Francisco , Horcas Vicent
Published: October 2024

Este artículo compara procesos participativos en los barrios del Cabanyal y Russafa (Valencia) indagando en sus efectos en la trama relacional y la convivencia. La investigación, con una metodología etnográfica, abre interrogantes sobre los impactos de los procesos participativos en las dinámicas de inclusión-exclusión de la diversidad sociocultural y en el tejido vecinal. Los resultados apuntan, por un lado, varias fortalezas en los procesos desde abajo porque facilitan la implicación de grupos plurales del vecindario y contribuyen a una convivencia más incluyente. Por otro, señalan la necesidad de repensar formas participativas desde arriba que, al no contemplar una dimensión comunitaria, reproducen la exclusión del vecindario precarizado. Sus efectos son limitados en términos de justicia social, aunque sí mejoren algunos espacios de convivencia barrial.
Impact of COVID-19 Lockdown on Emergency Department Visits, Hospital Admissions, and Mortality in Northern Jordan: An Interrupted Time Series Analysis
Authors:   University of Science and Technology,, Dalky Alaa , J. Ababneh Muhannad , M. Smadi Mahmoud , El-Bashir Mohanad , A. Raffee, Liqaa , Al-Kasasbeh, Abdullah
Published: October 2024

Background: The Jordanian healthcare system was significantly affected by the COVID19 pandemic, as lockdowns and infections strained the healthcare system. The impact of the ensuing national lockdown on emergency department visits, hospital admissions, and mortality is unclear. Purpose: To assess the impact of COVID-19 lockdown on the pattern of emergency department visits, hospital admissions, and mortality at a major hospital in northern Jordan. Methods: An electronic database belonging to King Abdullah University Hospital was used for a retrospective analysis, and the data was accessed in 2022. All patients who visited the emergency department before, during, and after the lockdown in 2020 and 2019 were analyzed using an interrupted time-series analysis. Descriptive statistics were calculated for categorical variables, followed by the Wilcoxon Signed-Ranks Test to detect mean differences. Results: ED visits decreased by 53.5% during the lockdown period and by 22% after the lockdown period compared to the same periods a year before. During lockdown, hospital admissions rose significantly from 11.8% in 2019 to 17.1% in 2020, with 23.96% critical care unit admissions. Post-lockdown, ED admissions increased from 11.3% in 2019 to 16.3% in 2020, with critical care admissions rising to 30.10%, and the mortality rate increased by 50%. Conclusion: The study concluded a decrease in hospital admissions and emergency visits during lockdown, but an increase in mortality rates. Future planning should focus on optimizing care for lifethreatening emergencies, improving national emergency preparedness, and developing Hospital Readiness Checklists for effective response to emergencies like COVID-19. Implications for Nursing: Nursing has faced challenges and changes due to the COVID19 lockdown. Patient admissions decreased after the 2020 lockdown, impacting nursing practice, mental health, and patient care. Nurses should be adapted to telehealth services, maintain care remotely, and address nurses’ mental health issues. Virtual tools should be utilized to connect with patients. Keywords: Jordan, COVID-19, Lockdown, Emergency department, Hospital admissions, Interrupted time series analysis.
Pengaruh Idiosinkratik Shinzo Abe Terhadap Gender Mainstreaming dalam Implementasi Womenomics
Authors: Karel Bua Ayu Tiara
Published: October 2024

Womenomics is a structural reform step carried out during the second term of Shinzo Abe’s government. This is surprising because Abe, who is considered convervative, dared to initiate policies that contrary to Japanese culture. This research aims to explain how Shinzo Abe's personality and leadership type have influenced womenomics policies and gender mainstreaming. This research uses qualitative research methods and data collection is done through literature study, from books, journal, articles, and websites. The result shows that Abe's idiosyncratic factors and leadership type had a significant influence on womenomics policy making. Family background, life experiences, relationships with political elites playing an important role in shaping Abe's mindset and interest on gender issues. Womenomics is one of the productions of knowledge owned by Shinzo Abe. Then the results of the analysis of Abe's leadership type shows that Abe is a conciliator type who emphasizes cooperation in achieving goals of womenomics through gender mainstreaming. This research suggest the further research on gender in Japan places more emphasis on the legacy of the womenomics policy to the new Prime Minister of Japan, Fumio Kishida.
Strategi Negara-Negara Baltik Dalam Menyikapi Keamanan Kawasan Terhadap Rusia Pasca Konflik Krimea
Authors: Mardiatmadja Abednego , Putranti Ika Riswanti , Hanura Marten
Published: October 2024

Konflik Krimea merupakan salah satu konflik yang merubah dinamika geopolitik dan geostrategi kawasan Eropa Timur. Hadirnya konflik ini tentunya meningkatkan potensi ancaman bagi keamanan dan stabilitas ketiga negara Baltik sebagai anggota NATO yang berbatasan langsung secara geografis dengan Rusia. Dengan keterbatasan kapasitas dan kapabilitas militernya, ketiga negara Baltik berusaha untuk mempertahankan kedaulatan kawasannya dari agresivitas Rusia. Penelitian ini bertujuan untuk menjawab bagaimana strategi negara-negara Baltik dalam menyikapi keamanan kawasan terhadap Rusia pasca konflik Krimea. Penelitian ini menggunakan teori kompleks keamanan kawasan dari Barry Buzan dan Ole Waever. Metode Penelitian ini disusun menggunakan metode penelitian kualitatif. Hasil penelitian ini menjelaskan bahwa dalam mempertahankan kawasannya, negara-negara Baltik menggunakan strategi pendekatan regional sebagai upaya untuk mendapatkan keamanan kolektif dari para mitra strategisnya, terutama NATO. Upaya diplomatis melalui OSCE juga dapat ditempuh sebagai salah satu opsi untuk menjaga stabilitas dan keamanan wilayahnya.
PENYEBAB KURANG TERWUJUDNYA PENGARUH CONSTRUCTIVE ENGAGEMENT BALI DEMOCRACY FORUM TERHADAP PROSES TRANSISI DEMOKRATIS MYANMAR
Authors: Adjinegoro Satrio , Putranti Ika Riswanti , Hanura Marten
Published: October 2024

Myanmar’s military regime, namely Tatmadaw, has taken over political influence for a lengthy amount of time, whether directly or indirectly. On the 1st February 2021, Tatmadaw launched a coup to once again take over leadership after denouncing the election results won by the National League for Democracy. With Tatmadaw back in leadership, democratization in Myanmar not only regressed, but also proved difficult to return to its original state. Additionally, Myanmar still has not been fully democratic even though it has participated in the Bali Democratic Forum because of Tatmadaw’s large dominance. After the coup was launched in 2021, Myanmar was not invited to BDF’s 14th meeting.This research will explain the effects of BDF’S Constructive Engagement on Myanmar’s democratic transition process. This research will use qualitative and explanative methods, which means that it will answer the research question using narrations and relevant data. This research will also use Darren Hawkins’ theory of democratization with the assistance of Huntington and McFaul. By using these theories, the answer found is that the effects of BDF on Myanmar’s democratic transition have not manifested because most of BDF’s recommendations are aimed towards the governments, but not towards the civil society.
PERSONALITAS ANGELA MERKEL DALAM UPAYA JERMAN MENGAKHIRI KRISIS LIBYA
Authors: Amelia Alifienna
Published: October 2024

Germany was one of the countries that actively pursued peace for Libya. The achievement of peace in Libya by Germany was carried out to overcome the surge in the number of refugees from the Middle East to Europe via the Mediterranean crossing. Angela Merkel's persistence in achieving peace in Libya was demonstrated by the holding of a series of peace processes known as the Berlin Process. This foreign policy cannot be separated from the influence of Angela Merkel as one of the policy-making units of the German government. Angela Merkel's role in ending the Libyan crisis is one of the next steps to rebuilding Libya. Commitments from external stakeholders influencing the conflict in Libya were successfully achieved at the Berlin Conference for Libya, a ceasefire agreement was reached, the Government of National Unity was confirmed, and the second Berlin Conference for Libya was held. Responding to this phenomenon, this study questions the role of Merkel's personality in Libya's peace efforts. In order to answer this question, the author uses a foreign policy analysis framework that identifies the relationship between the personality of the leader and the foreign policy taken. This study finds that Libya's peace efforts are a manifestation of Angela Merkel's dominant personality, namely the conciliator type and the participatory orientation.
UPAYA KOREA SELATAN DALAM MELINDUNGI HAK CIPTA KOREAN WAVE DARI PEMBAJAKAN KONTEN DIGITAL
Authors: Gintings Ruth Yemima Exaudia
Published: October 2024

Korean Wave, also known as Hallyu, is a popular culture of South Korean entertainment industry such as music, movie, serial drama, webtoon, and etc. These contents are protected as part of intellectual property, especially copyrights. But, their popularities come with infringement action, where pirated sites show South Korean movies and drama without any permission from the copyright holder. This study aims to explain South Korea’s effort to protect these Korean Wave contents. The framework used in this research are the intellectual property concept, especially copyrights, the globalization concept, and the sovereignty concept (Westphalian System). The globalization concept tries to analyze its effort to protect Korean Wave. This study uses a qualitative research method with the type of descriptive research, data obtained through literature study. This research shows that South Korea pretty success in tackling copyrights issues, though they still can’t solve it thoroughly.
Genetic variability, character association and path analyses effects on fiber yield and yield attributing morpho-agronomic traits of tossa jute (Corchorus olitorius L.)
Authors: Alam M J , Mukul M M , Yahiya A S M , Mahmud F , Bhuiyan M S R
Published: October 2024

Jute (Corchorus spp.) is a natural fiber crop having a lower extent of genetic variability due to its self-pollinating nature. The success of any breeding program for variety development primarily depends on the presence of genetic variation in the parental genotypes. A field experiment was conducted in a randomized complete block design at ManikganjStation of Bangladesh Jute Research Institute (BJRI) during 2019-2020. The genetic divergence of 58 tossa jute (C. olitorius) genotypes including two pre-released standard varieties (O-9897, BJRI Tossa pat 4) and 56 accessions were studied to select genotypes having the most divergence in natural rainy condition. The jute genotypes were categorized into five clusters based on Mahalanobis D2 analysis. Cluster I and IV showed maximum inter-cluster distance (181.44) while the maximum intra-cluster distance (16.15) was recorded in cluster I. Cluster V revealed the highest values for number of nodes, stem mid-diameter, core diameter, green weight with leaves, dry stick weight and dry fiber weight per plant while cluster IV showed higher means for plant height, green bark thickness and leaf area. The highest contribution (47.14%) was wielded by plant height of total deviations. The results recommended that hybridization between genotypes of cluster V, IV and III could provide a wide range of discrepancies in the segregating generation which could offer chance for isolation of good genotypes with high fibre yielding lines.
Discrimination grounds and personalised pricing: Consumer perceptions of fairness, norm alignment, legality, and trust in markets
Authors: Heidary Kimia , van der Rest Jean-Pierre , Custers Bart
Published: October 2024

This article explores consumer perceptions of different grounds by which online prices can be personalised. We conducted a survey among Dutch consumers (n = 727) presenting them with 25 segmentation bases, drawing from legally permissible and legally prohibited grounds. We then ranked these bases and accompanying consumer perceptions across five dimensions: fairness, alignment with personal norms, alignment with social norms, perceived legality, and trust in markets. We find that while consumer perceptions generally align with what is currently prohibited in law, there are some “new” grounds, in particular intelligence and physical appearance, that elicit similar negative perceptions as legally prohibited grounds. This raises questions regarding the further regulation of personalised pricing. We discuss pros and cons of updating legislation to better reflect (new) ethical and social norms.
“Our Goal is – Forward and Not to Retreat…” – Uprisings in the Small Ghettos Located in the Territories of Eastern Poland/Western Belarus and Ukraine – A Re-evaluation
Authors: Gershovich Leonid
Published: October 2024

The article analyses the phenomena of the revolts in small ghettos located primarely in the territories of current Belarus and Ukraine that used to be part of Poland during the interwar period. It suggests that one of the reasons for this phenomena was combined influence of life both in the interwar Poland and under the Soviet rule since september 1939 (untill the German-Nazi occupation in june-july 1941).
Relationship between indoor environmental quality and guests’ comfort and satisfaction at green hotels: A comprehensive review
Authors: Abdulaali Hayder Saadoon , Usman Ismar M. S. , Alqawzai Shagea
Published: October 2024

Recent studies have focused on different aspects of green management, practices, and green consumption in the hotel industry. However, there is a need to explore and better understand the association between indoor environmental quality (IEQ) and green hotel guest’s comfort. Therefore, it is essential to explore the effects of IEQ on the comfort and satisfaction of green hotel guests. This study conducts a comprehensive review of the effects of various IEQ parameters, including indoor air quality, thermal comfort, lighting, visual/view, acoustic comfort, building characteristics, decoration, and indoor greenery, on guest’s comfort and satisfaction in green hotels. Based on previous literature, it was also revealed that most current green building schemes lack of comprehensive evaluation of the performance of IEQ dimensions in green hotels. It was also observed that these IEQ parameters show a significant influence on the hotel guest’s comfort and satisfaction. Based on the findings of the literature review, a conceptual model was developed to represent the relationship between the IEQ parameters and guest’s comfort and satisfaction. The proposed conceptual model can be implemented by the hotel management for a comprehensive assessment of guests’ perceptions toward the IEQ in green hotels. The novelty of this study is based on its findings that establish a more effective IEQ evaluation method and serve as the reference scenario of IEQ, which can be a useful tool for both academician and practitioners and contribute to improving the indoor environmental performance of green hotels through highlighting the key IEQ parameters, which affect the comfort and satisfaction of hotel guests.
Assessment of surface hardness and impact strength of denture base resins reinforced with silver–titanium dioxide and silver–zirconium dioxide nanoparticles: In vitro study
Authors: Alwan Erhim Eman , Abbood Manal A. , Halbos Halemah T.
Published: October 2024

Polymethyl methacrylate (PMMA) is frequently utilised for fabricating denture bases due to its perfect qualities. However, a significant issue with this resin is the occurrence of frequent fractures caused by heavy chewing power, resulting in early cracks and fractures during clinical use. This study investigates the influence of silver, titanium dioxide, and silver zirconia nanoparticles on the surface hardness and impact strength of self-cured denture base. The samples were categorised into four categories according to the incorporation of different nanoparticles. The samples were divided into three subgroups based on the nanoparticle content: 0.1, 0.3, and 0.5% of TiO2 and ZrO2. Each group had a set ratio of 0.3% Ag as an antibacterial agent. Except for the fourth group (Group D), a combination of 0.05, 0.15, and 0.25% of TiO2 and ZrO2, along with 0.3% Ag, was utilised to investigate their collective impact. The Shore D hardness and Charpy test were employed to quantify the surface hardness and impact strength, respectively. The samples were subjected to X-ray diffraction analysis and field emission-scanning electron microscopy to characterise nanoparticles and ascertain the structure of acrylic samples. All nanoparticle-modified samples showed a substantial improvement in surface hardness compared to the control group. The maximum hardness value was seen in the samples containing 0.3% Ag–0.3% TiO2 and 0.3% Ag–0.5% ZrO2. The samples treated with 0.3% Ag and 0.3% TiO2 showed the maximum impact strength. The incorporation of Ag and ZrO2 hinders the ability to withstand impact strength. The samples treated with 0.3% Ag, 0.15% TiO2, and 0.15% ZrO2 exhibited an augmentation in impact strength. Modified samples in all groups showed a colour change, which required colour modifiers.
Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
Authors: Zhang Yao , Chen Lizhan , Ouyang Haifeng
Published: October 2024

Background

Asthma is an inflammatory disease where the balance between Th1/Th2 and Th17/Treg plays a crucial role in its pathogenesis. Shikonin is used to treat a variety of autoimmune diseases due to its good anti-inflammatory activity. However, the effect and mechanism of shikonin on asthma remain unknown.

Method

Mice were sensitized with ovalbumin (OVA)/house dust mite (HDM) and treated with shikonin. Lung inflammation was assessed histologically and via flow cytometry. Bronchoalveolar lavage fluid (BALF) was analyzed for cell counts and cytokines. Shikonin’s impact on p-STAT3 was studied in vivo and in vitro.

Results

Shikonin inhibited OVA or HDM-induced inflammation and airway hyperresponsiveness. Upon treatment, a restoration of the Th1/Th2 and Th17/Treg balance was observed, evidenced by a reduction in IL-4 and IL-17A levels in BALF, alongside an elevation in interferon-gamma and IL-10. Furthermore, shikonin impeded the infiltration of eosinophils, neutrophils, macrophages, and lymphocytes into lung tissue. The observed decrease in STAT3 phosphorylation and diminished nuclear translocation of p-STAT3 confirmed that shikonin promotes the balance of Th1/Th2 and Th17/Treg by regulating airway epithelial STAT3.

Conclusion

Shikonin mitigates asthma symptoms through a STAT3-dependent mechanism, indicating its potential as an anti-asthmatic therapeutic agent.
The chemoprotective hormetic effects of rosmarinic acid
Authors: Calabrese Edward J. , Pressman Peter , Hayes A. Wallace , Dhawan Gaurav , Kapoor Rachna , Agathokleous Evgenios , Baldwin Linda A. , Calabrese Vittorio
Published: October 2024

Rosmarinic acid is a polyphenol found in numerous fruits and vegetables, consumed in supplement form, and tested in numerous clinical trials for therapeutic applications due to its putative chemopreventive properties. Rosmarinic acid has been extensively studied at the cellular, whole animal, and molecular mechanism levels, presenting a complex array of multi-system biological effects. Rosmarinic acid-induced hormetic dose responses are widespread, occurring in numerous biological models and cell types for a broad range of endpoints. Consequently, this article provides the first assessment of rosmarinic acid-induced hormetic concentration/dose responses, their quantitative features, mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications.
The importance of historically reflexive critical thinking for police education: United States criminal justice and the brutalization of African Americans
Authors: Dallier Douglas J.
Published: October 2024

The value of college education for US police officers has been contemplated since at least the 1920’s, yet the importance of critical thinking has only recently attracted scholarly attention. Modern police training is frequently led by experienced former practitioners; however, as “insiders” they may be less likely to critically evaluate the role police play, and have played, in maintaining unjust and discriminatory systems, particularly for African Americans. This article considers existing scholarship on police training and education, highlighting and demonstrating the importance of historically reflexive critical thinking.
Fatigue dimples? – Fractured bulkhead ring bolts in a large gas turbine engine
Authors: Giller M. , Cagliyan E. , Neidel A.
Published: October 2024

Bulkhead ring fasteners, four in total, were found fractured in a large gas turbine engine after 1700 operating hours and a high number of engine starts and shut-downs for such a relatively short time in service. A metallurgical failure investigation was ordered by the client for determining the metallurgical cause of the cracking. The subject bolts failed due to high-stress low cycle fatigue fracture.
Quantum chemical calculations and molecular docking studies of 5-amino-3-(2,5-dimethoxyphenyl)-1-isonicotinoyl-2,3-dihydro-1H-pyrazole-4-carbonitrile
Authors: Nagalakshmi Rangarajan , Balachandran Vadivel , Viji Arangarajan , Narayana Badiadka , Alharethy Fahd , Murugan Ramadurai , Jothinathan Mukesh Kumar Dharmalingam , Sivasubramani Divya
Published: October 2024

The five-membered heterocycle pyrazole has two nitrogen atoms next to each other. Natural items and pharmaceuticals using pyrazole as the nucleus have demonstrated a wide range of biological activity. Medications with pyrazole cores may have better pharmacokinetics and pharmacological effects than medicines with similar heterocyclic rings. This is because the pyrazole core has unique physicochemical properties. In this study, 5-amino-3-(2,5-dimethoxyphenyl)-1-isonicotinoyl-2,3-dihydro-1H-pyrazole-4-carbonitrile is synthesized and characterized by means of spectrum and quantum chemical techniques. Using UV–vis absorption technique, Fourier transform infrared (FT-IR), and Fourier transform Raman (FT-Raman) techniques, the spectroscopic properties were examined. There were two regions visible in the experimental Raman as well as infrared spectra: 4,000–400 cm−1 along with 4,000–100 cm−1. The ideal molecular shape, vibrational frequencies, infrared intensity levels, and scattering from Raman were all assessed using density functional theory. The 13C (carbon) and 1H (proton) chemical shifts of the molecule were determined using nuclear magnetic resonance (NMR). The TD-DFT scheme was utilized to figure out speculative ultraviolet values and compare them to oscillator strength, electron excitation energies, and spectrum data from experiments. It is evident from the predicted HOMO-LUMO band separation energies that the transmission of charge takes place within a molecule’s structure. The chemical reactivity of the molecule has been calculated along with other global descriptive properties. Scientists investigated how charges move and the density of electrons inside a molecule using NBO analysis of the chemical they were studying. After examining the molecular electrostatic potential (MEP), a 3D picture was created that shows the compound’s nucleophilic and electrophilic areas. In addition to meeting all pertinent pharmacokinetic requirements, 5-amino-3-(2,5-dimethoxyphenyl)-1-isonicotinoyl-2,3-dihydro-1H-pyrazole-4-carbonitrile is also readily absorbed by the gastrointestinal system. Additionally, the chemical that was synthesized had a positive interaction with the target proteins of treatments for viruses, asthma, and heart failure, as shown by molecular docking.
Increasing Prevalence of Attention-Deficit/Hyperactivity Disorder in Patients With Borderline Personality Disorder
Authors: Huynh Kelly V. , Glass Isabel V. , Zanarini Mary C.
Published: October 2024

While research has shown that the prevalence of ADHD in the general population has increased over time, there have been no studies focused on ADHD prevalence in patients with borderline personality disorder (BPD). This study compares two cohorts of adults with rigorously diagnosed BPD recruited nearly three decades apart (1992 vs. 2020). Participants from the 1992 McLean Study of Adult Development (MSAD) (N = 290) and the 2020 Flourishing study (N = 147) were assessed for ADHD using DSM-III-R and DSM-5 criteria respectively. Compared to MSAD subjects, the prevalence of ADHD among Flourishing subjects was significantly higher overall, and in female (but not male) subjects. This increased prevalence, which is likely due to the broadening of the DSM criteria over time, highlights what many observers believe to be a problematic expansion of the diagnostic criteria for ADHD that may have decoupled this criteria set from capturing a neurodevelopmental disorder that typically begins in childhood.
A structural and optical modification of ZnO-Fe2O3 nanocomposite for enhancing catalytic activity
Authors:   Department of Physics, The University of Lahore, 53700, Pakistan, Rehman A. , Boota M. ,   Department of Physics, The University of Lahore, 53700, Pakistan, Khan M. I. ,   Department of Physics, The University of Lahore, 53700, Pakistan, Hussain A. ,   Department of Physics, The University of Lahore, 53700, Pakistan, Kanwal S. ,   Department of Physics, The University of Lahore, 53700, Pakistan, Atif M. ,   b Department of Physics and Astronomy, College of Science, King Saud University, P O Box 2455, Riyadh 11451, Saudi Arabia, Ahmad I. ,   Department of Physics and Astronomy, Texas Tech University, Lubbock, TX 79409, USA
Published: October 2024

This study investigates the photocatalytic degradation of organic Methyl Blue (MB) using a ZnO-Fe2O3 composite prepared via the sol-gel technique. FTIR analysis elucidates the substantial impact of Fe2O3 addition, as evidenced by shifts in the ZnO absorption bands, notably observed at 631 cm-1 and 919.74 cm-1 peaks. X-ray diffraction (XRD) corroborates heightened crystallinity due to interactions between ZnO and Fe2O3. SEM analysis unveils a highly aggregated structure, showcasing promising capabilities for efficient dye degradation and environmental applications. Photoluminescence (PL) spectra exhibit an intensified peak at 377 nm, indicative of efficient charge separation and electron transfer, offering potential in optoelectronic applications. The composite's distinctive refractive index (n) of 2.33, extinction coefficient (k) of 2.12, optical electronegativity (∆X*) of 0.75, and dielectric constants (εr of 0.40 and εi of 9.92) underscore its versatile bonding and broad application prospects. Evaluating the photocatalytic activity (PCA) reveals that among all samples, the nanocomposite ZnO-Fe2O3 synthesized at 500°C exhibits superior performance, showcasing heightened degradation of MB dye under 90 minutes of sunlight irradiation.
The Effect Of Medical And Social Factors On The Health Of Children Born As A Result Of ART In Late Reproductive Age Women
Authors: Kirill A. Kuzmichev , Olga V. Tyumina , Olga А. Khashina , Valeria V. Sokolova , Elizaveta A. Gusarova
Published: October 2024

Background — This article is dedicated to the study of the effect of medical and social factors on the health of children born as a result of assisted reproductive technology (ART) in late reproductive age (LRA) women. Every year, there is a deterioration in the reproductive health of married couples, an increase in the frequency of infertile marriages, as well as an increase in the number of women over 35 years of age who gave birth to children as a result of ART. Material and Methods — The study included 648 children (4-6 years old) born as a result of ART by women aged 35-45 years (the main group: MG). All children resided in the city of Samara. The control group (CG) included 648 children (4-6 years old) who were born from spontaneous conception and met the following criteria: their mother’s age at birth exceeding 35 years, their age from 4 to 6 years, born from a singleton full-term (≥37 weeks of gestation) pregnancy. The main distinguishing feature between the MG and CG was birth after using ART. The children’s health was assessed comprehensively, based on the results of physical and medical examinations, and a study of the child’s development history. The course of pregnancy and childbirth, along with maternal morbidity, based on outpatient medical records, as well as their social and hygienic characteristics based on questionnaire data, were investigated. The following research methods were employed: sociological (questionnaire), direct observation, analytical, and statistical. Results — We assessed children’s health as follows: the subgroup with good health included 18.0% of children in the MG vs. 21.9% in the CG (p=0.055). The proportion of the subgroup of children with poor health was 56.2% in the MG vs. 36.1% in the CG (p=0.048). Conclusion — We identified 18 significant risk factors that negatively affected the health of children born as a result of ART in LRA women.
Germline Variants Of The MMR/EPCAM Genes In Russian Patients With Lynch Syndrome
Authors: Tsukanov Aleksey S. , Barinov Aleksey A. , Shubin Vitaly P. , Loginova Anna N. , Pikunov Dmitry Yu. , Shakhmatov Dmitry G. , Shelygin Yuri A. , Achkasov Sergey I.
Published: October 2024

Objective — Lynch syndrome is the most common hereditary cancer syndrome caused by pathogenic variants in the MMR/EPCAM genes. Our goal was to study the germline variants of these genes in the largest sample of patients with Lynch syndrome in Russia. Methods — The study included data on pathogenic and likely pathogenic variants in the MMR/EPCAM genes collected from the local Registry of Hereditary Colorectal Cancer of Ryzhikh National Medical Research Centre for Coloproctology (RNMRCC). We analyzed all available data on 141 probands with Lynch syndrome: 78 men and 63 women aged 21 to 80 years treated at RNMRCC from 2012 through 2023. Results — The numbers of pathogenic and likely pathogenic variants detected in the key genes were as follows MLH1 (69 probands), MSH2 (57), MSH6 (10), EPCAM (3), PMS2 (1), and PMS1 (1). Of the 141 germline variants, 17 (12.1%) were detected for the first time: MLH1 (8 probands) MSH2 (8), and MSH6 (1). Thirteen (9.2%) of the detected variants were associated with large deletions/duplications. The most frequent pathogenic variants in the MLH1 gene were c.1852_1854del (9 probands), c.350C>T (4), and c.1459C>T (3). The most frequent pathogenic variants in the MSH2 gene were c.942+3A>T (9 probands) and c.1288A>T (3). Conclusion — Our results allowed establishing the frequency and spectrum of different types of germline variants in the MMR/EPCAM genes, which helped optimize the algorithm for selecting and diagnosing Russian patients with Lynch syndrome.
Usos e actitudes lingüísticas no portugués de Olivenza
Authors: Flores Tamara , Gómez Alberto
Published: October 2024

En 1801, durante a Guerra das Laranxas, o territorio portugués de Olivenza foi ocupado polas tropas comandadas por Manuel Godoy e pasou a ser administrado por España (Tratado de Badaxoz, 1801). Esta mudanza de soberanía traerá fondas alteracións en diversos aspectos da vida deste territorio xunto ao río Guadiana, entre eles tamén o lingüístico. Neste contexto, o castelán desprazou o portugués e tornouse a lingua da nova administración, relegando o idioma luso a un segundo plano. Pasados máis de dous séculos, a lingua portuguesa en Olivenza vive hoxe unha situación moi precaria, as medidas de protección son escasas ou nulas e o encadramento legal practicamente inexistente.
Este artigo presenta os resultados dunha investigación sobre a situación sociolingüística de Olivenza. Para acadar ese obxectivo, presentamos unha análise dos usos e das actitudes lingüísticas extraídas dun corpus constituído por entrevistas realizadas a cidadáns e cidadás da cidade de Olivenza e o seu alfoz. Os resultados preliminares revelan que o portugués en Olivenza se encontra nunha clara situación de minorización e que as actitudes lingüísticas dos oliventinos non son, en xeral, moi favorables ao uso e preservación da lingua portuguesa.
Role of platelets in the pathogenesis of antiphospholipid syndrome
Authors: NK Singh  , Behera Dibya R , DP Yadav  , A Gupta  , D Dash  , D Bandyopadhyay
Published: October 2024

Aim To delineate the role of platelets in thrombotic process in APS patients.BackgroundPathogenesis of APS is an ongoing area of research and studying the role of platelets will be helpful in developing newer diagnostic and therapeutic strategies.Materials and mgethodsForty patients with APS, diagnosed as per modified 2006 Sapporo’s Criteria and who were not on aspirin or any other antiplatelet drug, were included. The same number of age- and sex-matched healthy controls was also recruited for comparison. The following platelet function studies were performed using the blood samples collected from APS patients as well as healthy controls: platelet aggregation studies, platelet secretion of dense granules (a. total degranulation b. platelet secretion of granules in relation to time c. visualization of platelet degranulation), clot retraction studies, and western blot studies on clot retracted samples for demonstration of activated proteomes.
¿Estamos perdiendo los humedales más rápido de lo que podemos restaurarlos?
Authors: Corrales Chaves Lenin
Published: October 2024

The critical importance of wetland ecosystems is highlighted, as they provide essential services such as regulating the hydrological cycle, flood control, and filtering pollutants. Globally, 64 % of wetlands have been lost since 1970, with Asia being the most affected region. Agricultural expansion, urban development, and aquaculture are some of the main drivers of the degradation of these ecosystems, particularly mangroves, which play a key role in climate change mitigation.  In Costa Rica, wetlands under inventory represent 6.01 % of the national territory, and although the country has made progress in their protection, with 49 % of wetlands falling under some category of protected wild area, challenges remain, such as agricultural expansion, livestock farming, and sedimentation.  At the international level, the Ramsar Convention has been key to wetland conservation efforts, with over 2.57 million km2 protected. However, additional efforts are needed to mitigate the threats to these ecosystems, especially in the context of climate change.
АПРИОРНЫЕ ГРАНИЦЫ ОШИБКИ ДЛЯ ПАРАБОЛИЧЕСКИХ ИНТЕРФЕЙСНЫХ ЗАДАЧ С ДАННЫМИ ИЗМЕРЕНИЙ
Authors: СЕН Г.Д.
Published: October 2024

В данной статье рассматривается априорный анализ ошибок для линейных параболических интерфейсных задач с данными измерений во времени в ограниченной выпуклой многоугольной области в R2. Анализируются как пространственно дискретные, так и полностью дискретные аппроксимации. Мы используем стандартную непрерывную дискретизацию методом конечных элементов для пространства, в то время как для дискретизации по времени используется неявная аппроксимация Эйлера. Ввиду низкой регулярности данных задачи решение имеет очень низкую регулярность во всей области. Априорные границы ошибки в L2(L2(Ω))-норме как для пространственно дискретной, так и для полностью дискретной конечно-элементных аппроксимаций получаются при минимальной регулярности с помощью L2-проекционного оператора и двойственности. Для подтверждения теоретических выводов были проведены численные эксперименты. Для нашей цели предполагается, что интерфейсы гладкие.

This article studies a priori error analysis for linear parabolic interface problems with measure data in time in a bounded convex polygonal domain in R2. Both the spatially discrete and the fully discrete approximations are analyzed. We have used the standard continuous fitted finite element discretization for the space while, the backward Euler approximation is used for the time discretization. Due to the low regularity of the data of the problem, the solution possesses very low regularity in the entire domain. A priori error bounds in the L2(L2(Ω))-norm for both the spatially discrete and the fully discrete finite element approximations are derived under minimal regularity with the help of the L2-projection operator and the duality argument. Numerical experiments are performed to underline the theoretical findings. The interfaces are assumed to be smooth for our purpose.
Antibacterial performance of biodegradable polymer and hazelnut husk flour antibacterial biofilm with silver nanoparticles
Authors: Ayrilmis Nadir , Yurttas Elif , Tetik Nurten , Özdemir Ferhat , Palanisamy Sivasubramanian , Alagarsamy Aravindhan , Ramasamy Siva , Sillanpää Mika , Al-Farraj Saleh A .
Published: October 2024

The antibacterial performance of biocomposite films prepared from lignocellulosic waste (hazelnut husk or hazelnut leafy green cover) modified with silver nanoparticles and polylactic acid (PLA) was determined. The amount of hazelnut husk in the PLA matrix ranged from 10 to 40% by weight in 10% increments. The composite pellets were produced using a twin-screw extruder. Biocomposite films of 0.6 mm x 40 mm x 200 mm were produced from the pellets in a laboratory hydraulic hot press. The surfaces of the modified hazelnut husk and biocomposite specimens were analyzed by scanning electron microscopy (SEM) and inductively coupled plasma optical emission spectrometry (ICP-OES). The antibacterial activity of the biocomposite films against Staphylococcus aureus bacteria was determined using the ASTM E 2149 (2020) method. The antibacterial activity of the biocomposite films increased noticeably with the addition of hazelnut husk modified with the silver nanoparticles. Compared to the pure PLA film, the biocomposite films with 10 wt% modified husk flour showed the lowest antibacterial activity (31.3%) against S. aureus over 24-h while the films with 40 wt% showed the highest antibacterial activity (99.9%). The biocomposite films made of hazelnut husk flour with silver nanoparticles and PLA matrix could be considered for food packaging applications.
Rubber seed shell as low-cost medium to produce lactic acid using Lactobacillus plantarum LB2 and fabrication of a polylactic acid-chitosan composite for fish fillet packing
Authors: Muthuramamoorthy Muthumareeswaran , Aldalbahi Ali , Radi Alanzi Khwater Mishaal , Pandiaraj Saravanan , Karuppiah Ponmurugan
Published: October 2024

Rubber seed shell (Hevea brasiliensis) was used as a low-cost substrate to produce lactic acid via Lactobacillus plantarum LB2. The medium components were initially screened by two-level full factorial design. Three variables (pH, moisture, and polyoxyethylene sorbitan monooleate (PSM)) were used in the central composite design and response surface methodology. The amount of PSM was found to be a significant variable in lactic acid production. Lactic acid was purified and used for the chemical fabrication of a polylactic acid-chitosan composite film. Compared with the polylactic acid, the composite film improved the tensile strength, elongation strength, and tearing strength. The film prepared with 1% chitosan-polylactic acid exhibited the maximum antibacterial activity against Bacillus cereus (21 ± 1 mm) and the lowest activity against Escherichia coli (10 ± 1 mm). The polylactic acid-chitosan film prepared with 1% chitosan was used as a packing material to store the fish fillets and presented reduced mesophilic (4.3 ± 0.1 Log CFU/g) and psychrotropic (3.2 ± 0.2 Log CFU/g) bacterial populations compared with those of the control (4.9 ± 0.2 Log CFU/g and 3.7 Log CFU/g). Rubber seed shells can be used as an alternative culture medium for lactic acid production, to reduce the production cost of polylactic acid.
Cirugía transanal mínimamente invasiva: experiencia en un servicio especializado en Perú
Authors: López-Cutipa Ever Frank , Borda Mederos Luis , Shimabukuro Miyagui Roberto Takashi , Alvarado-Ortiz Eduardo , Auris-Mora Hugo , Milla Meza Guillermo , Sandoval Jauregui Javier , Arenas Gamio José Luis , Terry-Castellano Luis Edilberto , Chiroque-Benites Luis
Published: October 2024

Introduction. Transanal minimally invasive surgery (TAMIS) is a procedure implemented in several centers around the world, showing high-quality local excision in rectal neoplasms. Objective. To describe the results of the experience of minimally invasive transanal surgery for local excision of rectal tumors at the Guillermo Almenara National Hospital, Lima, Peru. Methods. A descriptive, cross-sectional design study was carried out on all patients undergoing TAMIS during the period June 1, 2019 to December 31, 2023. Evaluating clinical, surgical, pathological variables and complications. Results. 16 patients were included. The mean age was 57 years (range 15 - 82). The mean size of the lesions was 3.5 cm (range 1.3 - 9 cm) and the mean height of the tumor at the anal margin was 8.6cm (range 4 - 20 cm). The final pathology results were: 9 benign lesions, 1 neuroendocrine tumor and 6 rectal adenocarcinomas, within these 4 cases were Tis, 1 was T1 sm1 and the other T1 sm2. 3 cases with preoperative adenoma biopsy turned out to have adenocarcinoma in the final pathology. The frequency of fragmented pieces was 6.3%. The mean postoperative stay was 4.4 days. The frequency of complications was 12.5%. No local recurrence was evident during follow-up. Conclusions. TAMIS is a safe, feasible and low-morbidity procedure for the resection of benign neoplasms and in selected cases of early-stage rectal cancer.
Multiple primary cutaneous melanoma in the amazon region of Peru
Authors: Laureano Suárez Rocío , Camones Huerta José , Ortíz Muchotrigo Nazario , Ramírez García Edgar A. , Casapía Morales Martín
Published: October 2024

Reportamos el caso de un hombre de 82 años residente de Iquitos, región amazónica del Perú, con una historia de tres meses de lesiones cutáneas dolorosas de leves a moderadas en la extremidad inferior derecha. El examen clínico reveló cuatro tumores en la tibia derecha, que exhibían crecimiento exofítico, apariencia verrugosa y ulceración. Se observaron dos nódulos subcutáneos. Se observó linfadenopatía inguinal agrandada. El examen histopatológico reveló un diagnóstico de melanoma. Este caso enfatiza la necesidad de una vigilancia integral y multidisciplinaria en regiones con datos limitados sobre melanoma que conducen a un subdiagnóstico de esta malignidad. Además, destaca la importancia de la prevención  primaria como la protección solar en zonas tropicales para prevenir el melanoma cutáneo, abogando por aumentar la concienciación y las medidas preventivas.
Cumplimiento de recomendaciones de consumo de alimentos altos en fibra por personal de salud de un hospital peruano
Authors: Mamani-Urrutia Víctor , Ccorimanya-Maita Julia , Melgar Benavides Guido Omar
Published: October 2024

Sr. Editor,
La fibra dietética en frutas, verduras y granos enteros beneficia la salud digestiva, previene el estreñimiento y reduce riesgos de enfermedades crónicas a largo plazo (1). El consumo adecuado de fibra es esencial para el personal de salud, proporcionando bienestar, energía y apoyo en la gestión del estrés y la prevención del agotamiento durante sus demandantes labores físicas y mentales (2). Por ello, se buscó determinar la proporción de cumplimiento de recomendaciones de consumo de alimentos altos en fibra en personal de salud perteneciente al Hospital Nacional Daniel Alcides Carrión de Perú.
Producción científica de un instituto especializado en salud materna, perinatal y neonatal peruano
Authors: Guillen-Calle Brandon E. , Rodriguez-Clemente Nicole
Published: October 2024

Sr. Editor,
El Instituto Nacional Materno Perinatal (INMP), desde su inicio como la Casa de Maternidad en 1826, ha sido fundamental en la evolución de la medicina materna y neonatal en Perú, y con una historia rica y comprometida con la salud de las madres y los recién nacidos, ha evolucionado para convertirse en un referente en la atención y la investigación en salud materno-neonatal (1,2). En este contexto, resultó crucial evaluar y entender el impacto de sus investigaciones científicas a lo largo del tiempo y proporcionar una visión detallada de su contribución al conocimiento y la ciencia médica, así como su colaboración a nivel internacional en los últimos 17 años.