bluuebunny/crossref_metadata_2025 huggingface dataset:
Çok Ölçütlü Karar Verme Yöntemleri ile Kağıt Fabrikası Kuruluş Yeri Seçimi
Authors: YEŞİLKAYA Murat
Published: February 2019

Küreselleşen dünya ve artan rekabet şartları göz önünde bulundurulduğunda, işletmelerin başarıları açısından kuruluş yerinin belirlenmesi kritik öneme sahiptir. Türkiye’de ekonomik potansiyeli olan kağıt endüstrisinde kuruluş yeri tespit edilmesi sektör yatırımları açısından önem arz etmektedir. Sektörde özellikle son yıllarda tersine lojistiğin en önemli uygulama alanlarından olan atık kâğıtların geri dönüşümü ile büyük oranda hammadde kaynağı sağlamaktadır. Bu çalışmada, kağıt fabrikası kuruluş yeri tespiti için beş aday şehir arasından en uygun yerin belirlenmesine yönelik bir karar destek modeli önerilmiştir. Bu maksatla, kuruluş yeri alternatiflerinin çeşitli olması ve kriterlerinin karmaşık olması nedeniyle sıkça kullanılan matematiksel ve mantıksal model temelli çok ölçütlü karar verme yöntemleri kullanılmıştır. Çalışmada kuruluş yeri değerlendirme kriterleri olarak; pazar, işgücü, hammadde, ulaşım, teşvikler, atıklar, enerji ve arazi olarak belirlenmiştir. Uygulamada AHP, TOPSIS ve PROMETHEE yöntemleri ile çözümler yapılmış ve sonuçlar karşılaştırılmış etkin karar verilmiştir. Bu uygulamanın diğer endüstrilerde yapılacak kuruluş yeri seçim problemleri için bir öngörü oluşturacağı düşünülmektedir. 
Evaluation and Management of Women who Have Experienced Stillbirth in Their Previous Pregnancies
Authors: Fadiloglu Erdem , Tanacan Atakan , Unal Canan , Beksac Mehmet Sinan
Published: February 2019

Objective: To evaluate the subsequent pregnancy outcomes of women who have experienced unexplained stillbirth in their previous gestations.Study Design: This retrospective cohort consisted of 14 pregnancies who had stillbirth (without known risk factors) in their previous pregnancies. These patients had been included in a special preconceptional care program to be evaluated in terms of etiological risk factors for stillbirth. At least one of the risk factors, such as methylenetetrahydrofolate reductase (MTHFR) polymorphisms, hereditary thrombophilias and autoimmune problems, were defined in this study population. After detection of pregnancy, the patients were administered low-dose low-molecular-weight heparin (LMWH) (enoxaparin, 1×2000 Anti-XA IU/0.2 mL/day), low-dose salicylic acid (100 mg/day) and low-dose corticosteroid (methylprednisolone, 1×4 mg/day orally) in necessary cases.Results: Out of 14 pregnancies, 4 (28.5%) ended up with miscarriages at 9, 11, 11 and 15 gestational weeks, respectively. The remaining 10 pregnancies ended up with alive deliveries. The mean gestational week at birth was 36.4±0.51, while the mean birthweight was 2882±381.01 g. Out of 10 pregnancies, only one was diagnosed as IUGR. Only two newborn necessitated hospitalization in the neonatal intensive care unit (NICU) due to respiratory problems. Both newborns were discharged from the NICU without any further complication at the post-partum 5th day. Conclusion: Patients with a prior stillbirth should be screened for MTHFR polymorphisms, autoimmune problems and hereditary thrombophilias, especially in case of absence of any etiological factor. Management of these patients with low-dose aspirin, low-dose low molecular weight heparin and corticosteroids seemed to be beneficial for increasing live birth rates and avoiding obstetric complications.
Probabilistic forecasting of coastal wave height during typhoon warning period using machine learning methods
Authors: Chen Shien-Tsung
Published: February 2019

This study applied machine learning methods to perform the probabilistic forecasting of coastal wave height during the typhoon warning period. The probabilistic forecasts comprise a deterministic forecast and the probability distribution of a forecast error. A support vector machine was used to develop a real-time forecasting model for generating deterministic wave height forecasts. The forecast errors of deterministic forecasting were then used as a database to generate probabilistic forecasts by using the modified fuzzy inference model. The innovation of the modified fuzzy inference model includes calculating the similarity of the data by performing fuzzy implication and resampling the potential data from the fuzzy database for probability distribution. The probabilistic forecasting method was applied to the east coast of Taiwan, where typhoons frequently cause large waves. Hourly wave height data from an offshore buoy and various typhoon characteristics were used as inputs of the probabilistic forecasting model. Validation results from real typhoon events verified that the proposed probabilistic forecasting model can generate the predicted confidence interval, which can properly enclose the observed wave height data, excluding some cases with extreme wave heights. Moreover, an objective measure was used to validate the proposed probabilistic forecasting method.
Speciation and seasonal variation of various disinfection by-products in a full-scale drinking water treatment plant in East China
Authors: Zhou Xiang-Ren , Lin Yi-Li , Zhang Tian-Yang , Xu Bin , Chu Wen-Hai , Cao Tong-Cheng , Zhu Wen-Qian
Published: February 2019

The objective of this research was to study the occurrence and seasonal variations of disinfection by-products (DBPs), including traditional carbonaceous and emerging nitrogenous DBPs, in a full-scale drinking water treatment plant (DWTP) for nearly 2 years. The removal efficiencies of each DBP through the treatment processes were also investigated. This DWTP takes raw water from the Yangtze River in East China. The quality of the raw water used in this DWTP varied with different seasons. The results suggested that DBP concentrations of the finished water were higher in spring (82.33 ± 15.12 μg/L) and summer (117.29 ± 9.94 μg/L) with higher dissolved organic carbon (DOC) levels, but lower in autumn (41.10 ± 5.82 μg/L) and winter (78.47 ± 2.74 μg/L) with lower DOC levels. Due to the increase of bromide concentration in spring and winter, more toxic brominated DBPs increased obviously and took up a greater proportion. In this DWTP, DBP concentrations increased dramatically after pre-chlorination, especially in summer. It is noteworthy that the removal of DBPs during the subsequent treatment was more obvious in spring than in the other three seasons because the pH value is more beneficial to coagulation in spring.
The theory of injection of a hydrate-forming gas into a snow massif saturated with the same gas
Authors: Chiglintseva A.S. , Shagapov V.Sh.
Published: February 2019

The mathematical model of the process of gas hydrate formation during gas injection into a snow massif, saturated with the same gas, is constructed. In axisymmetric formulation, analytical solutions are obtained for the distribution of temperature fields, pressures and phase saturations. It is shown that the appearance of various characteristic zones in a snow massif depends on the initial state of the gas–snow system, determined by temperature and pressure, and the mass flow rate of the injected gas. It has been established that an increase in the intensity of gas injection (gas flow rate) leads to an increase in both the length of the bulk zone of hydrate formation and the increase in the fraction of hydrate at the boundary separating the near and intermediate zones.
Determination of local inhomogeneity of the medium from the natural frequencies of string oscillations
Authors: Utyashev I.M. , Akhtyamov A.M.
Published: February 2019

The paper considers the problem of determining the local inhomogeneity of the medium from the natural frequencies of string oscillation. The inhomogeneity is modeled in three sections: in the first and third sections medium is homogeneous, and on average section the elastic characteristics are modeled by a quadratic function. This model is implemented using the conjugation conditions at boundary between media. It is shown that to identify the center of an inhomogeneity and determine its size, two natural frequencies are enough, and in the case of rigid fixing of both ends of the string, the solution of the problem is dual. The problem is solved by expanding the fundamental system of solutions into a power series in the variables x and λ. The estimates of the error of the method are given.
The model of the servo piston of the fuel metering unit using matrix approach and neural network
Authors: Denisova E.V. , Chernikova M.A.
Published: February 2019

In the paper, the model of a servo piston of a fuel metering unit based on a matrix approach using neural networks is considered. To develop the model of a servo piston, the dependence of the initial piston deviation on the control signal for different values of the nozzles is used. This dependence is represented in the form of a matrix and is used in the neural network. This approach allows describing the movement of the servo piston with a sufficient degree of accuracy. As a record of change squares adjustment of the nozzles is a source of parametric uncertainty in the operation of the automatic control system can lead to a drop in the quality of control, such accounting is relevant. The model of the servo piston is proposed to be used in the structure of the automatic control system for a gas turbine engine and for semi-natural stands.
Study of the effect of dynamic blocking of emulsions containing solid inclusions
Authors: Rakhimov A.A. , Akhmetov A.T. , Valiev A.A. , Asadullin R.R.
Published: February 2019

The paper presents the results of experimental studies of the flow of stabilized water-oil emulsions prepared from oil and formation water from the wells of the West Kochevne field, as well as with the presence of chrysotile and aerosil in cylindrical and flat capillaries (in the crack patterns). The effect of dynamic blocking has been discovered, which consists in the fact that in sections of capillaries and in a model of cracks, with a constant pressure drop, the flow of reverse oil-water emulsions stops with time. An increase in the content of isotropic and anisotropic particles led to an increase in the viscosity of the emulsion and a decrease in the time of onset of dynamic blocking. With the same percentage of particles in emulsions containing chrysotile, the time of onset of blocking and the volume of leaked emulsion before blocking is an order of magnitude less than that of emulsions containing aerosil. However, in this case, the viscosity of the emulsion with aerosil is even higher than that of a similar emulsion with chrysotile.
The system of information markers of the mobile robots collective
Authors: Alekseev A.Yu.
Published: February 2019

The article discusses the use of AR (Augmented Reality) markers — extended virtual reality for monitoring the status of a robots group. The structure of the marker and the method of forming a package of dynamic two-dimensional code are described. The results of a comparative analysis of perspective screen technologies for displaying dynamic markers are presented.
Conservative Scheme Application for the Numerical Modeling of the Diffusion Problem for a Single Bubble in an Acoustic Field
Authors: Butyugina E.V. , Nasibullaeva E.Sh. , Akhatov I.Sh. , Gumerov N.A.
Published: February 2019

In the present study a numerical method for simulation of the diffusion problem for a single gas bubble oscillating in an acoustic field is developed. The method is based on the conservative numerical scheme for the diffusion equation where diffusion flux continuity is acting as conservation law. This method allows one to take into account the influence of changing mass of the gas inside the bubble on the strongly nonlinear dynamics of a bubble. The numerical results obtained using the proposed method utilizing conservative scheme and the standard scheme, which does not conserve the total mass of the gas-liquid system, reveals that in the latter case the numerical error may accumulate and lead to physically incorrect results.
Determination of surface tension by molecular dynamics methods for monatomic substances
Authors: Malyshev V.L. , Maryin D.F. , Moiseeva E.F. , Gumerov N.A. , Akhatov I.Sh.
Published: February 2019

The results of the calculation of surface tension by the molecular dynamics method for the liquid-gas system based on the example of argon are presented in the article. The method was verified by comparing numerical results with experimental data. The results on the determination of the optimal trimming radius for the interaction potential are presented.
Scheme of the computational experiment for the construction of an element of the research stand of the fuel metering unit
Authors: Nasibullayev I.Sh. , Nasibullaeva E.Sh. , Denisova E.V.
Published: February 2019

In this paper, the motion of a piston in a cylindrical tube is numerically studied with influence of dry and viscous friction and spring elasticity. Leading factors for models with dry and viscous friction are determined. A scheme for performing a full factorial computing experiment is proposed, where fuel consumption per unit time and fuel consumption for the period of periodic flow are chosen as objective functions.
On natural flexural vibrations of a step-up rod with distributed attached mass
Authors: Khakimov A.G.
Published: February 2019

The paper discusses natural flexural vibrations of a step-up rod with distributed attached mass. It is shown that an increase in the step coordinate results in rising natural frequencies of the vibrations in the range of parameters under consideration. It is revealed that as the ratio of polar moments of inertia in the steps grows, the lowest two frequencies of natural flexural vibrations in the rod tend to decrease. Also, the lowest frequencies of natural flexural vibrations in the rod decrease with growing intensity of the distributed attached mass. The solution to the inverse problem makes it possible to define the step coordinate, the ratio of polar moments of inertia in the steps and the intensity of the distributed attached mass using the lowest three frequencies of free flexural vibrations in the step-up rod.
Invariant submodels of a rank 2 with rotation for the equations of gas dynamics
Authors: Yulmukhametova Yu.V.
Published: February 2019

The various invariant submodels of a rank 2 allowing the operator of rotation for the equations of gas dynamics with the arbitrariest equation of state are considered. It is shown that such submodels come down to an ordinary differential equation of the second order.
Fases de desenvolvimento de Oxelytrum discicolle (Brullé, 1840) (Silphidae, Coleoptera) na região nordeste de Santa Catarina
Authors: Bonfanti Carla Fabiana , Gaedke Anderson , Mouga Denise Monique Dubet da Silva
Published: February 2019

A espécie Oxelytrum discicolle (Brullé, 1840) (Silphidae, Coleoptera) é uma das mais abundantes em levantamentos entomológicos forenses. Em função de diferenças observadas no relato do desenvolvimento dessa espécie em relação a dados originados no estado de Santa Catarina, realizou-se o estudo dos estágios de desenvolvimento da espécie em laboratório. Os adultos foram coletados em armadilha tipo Tomahawk, em fragmento urbano de mata atlântica em Joinville (SC). Depois foram armazenados em recipiente plástico com solo e tampa perfurada, sendo mantidos a temperatura ambiente, fotoperíodo de 12:12 e alimentados com larvas de mosca. Os ovos produzidos foram transferidos para recipientes plásticos menores, com orifícios e solo, umedecidosconforme necessidade, mantidos em temperatura de 25°C. Os imaturos foram alimentados com larvas de mosca descongeladas. Anotaram-se a data e a hora de cada evento de desenvolvimento. As larvas foram verificadas em diferentes instares para análise de tamanho. Obtiveram-se dados para tamanho e tempo de desenvolvimento, que se diferenciam em relação a trabalhos anteriores. Os dados atualizados de tamanho e tempo de desenvolvimento da espécie, para a região, possibilitarão a correta identificação dos instares larvais encontrados em cadáveres humanos, permitindo uma estimativa mais precisa do intervalomínimo pós-morte.
Mãos e memórias (auto)biográficas de um artesão: a escuta de uma arte-terapeuta
Authors: Böhr Eliane , Dittrich Maria Glória , Venera Raquel Alvarenga Sena
Published: February 2019

Este artigo é parte dos resultados de uma pesquisa de dissertação queobjetivou registrar histórias de vida de pacientes com esclerose múltipla, visibilizandoas como patrimônios culturais e analisando a relação entre as narrativas (auto) biográficas e as expressões artísticas. A empiria foi constituída dos discursos (auto) biográficos e mandalas, produzidas em situação de pesquisa, que registraram fragmentos dessas vidas em formas de cores. O artigo recorta a narrativa (auto) biográfica de um homem de 62 anos que vive os sintomas da esclerose múltipla hácerca de 18 anos. Estrangeiro e artesão, emprestou sua história para as reflexões sobre os sentidos de vida expressas em narrativas e no seu artesanato. A perspectiva hermenêutico-fenomenológica das pesquisas (auto)biográficas com base em Delory-Momberger (2016) foi a escolha de escuta dessa narrativa de vida, e a teoria do corpo criante, de Dittrich (2010), disparou reflexões acerca das condições de produção criativa do entrevistado. Desse lugar, algumas reflexões foram tecidas em diálogo com registros sobre a vida do artista Matisse em uma fusão entre o artesanal, a narrativa e as limitações motoras das mãos do artesão. Trata-se de um esforço reflexivo dos sentidos de uma vida com esclerose múltipla.
O biógrafo e os segredos da narrativa biográfica: o roteiro para as memórias de Joinville
Authors: Garcia Boldorini Marília , Barros Meira Roberta
Published: February 2019

Desde o século XVII, quando houve o chamado nascimento do autor, aquestão da autoria textual passou a ter bastante relevância, seja quanto ao público, seja quanto ao mercado editorial. Nessa direção, este artigo traça um perfi l sobre o elemento da autoria, explorando entrevistas semiestruturadas feitas com os autores de duas narrativas biográfi cas – Primavera em pleno outono: a jovem Olívia faz 80 anos!, de Wilson Gelbcke, e Eu, Wittich Freitag, de Raquel S. Thiago. Ademais, a abordagem tem como perspectiva a relação entre o processo de desenvolvimento do texto biográfico e questões peculiares concernentes ao gênero, refletindo acerca do modo de fazer a biografia. Ressalta-se, igualmente, o discurso dos entrevistados e o que diz a literatura específica. Além disso, o lugar de fala dos entrevistados também é averiguado aqui, na medida em que um deles é historiador, e o outro, escritor profissional. Por fim, procura-se apontar, nesse caso, as diferenças e/ou assimilaridades de percepção sobre o que narrar a respeito do/a biografado/a e comodesenvolver tal narrativa.
Casa Krüger: reflexões sobre um patrimônio histórico edificado
Authors: Dalonso Fernanda , Carelli Mariluci Neis , Rocha Bandeira Dione da
Published: February 2019

Este artigo tem como proposta refl etir sobre o patrimônio histórico edificado Casa Krüger como um bem cultural, tratando-o como cultura material atravessada pelo processo de patrimonialização e inserida na paisagem dos Roteiros Nacionais de Imigração em Santa Catarina. Essa casa, situada na Estrada Dona Francisca, em Joinville, foi construída entre 1890 e 1900 com a técnica do enxaimel. O tombamento estadual do imóvel ocorreu em 1994, e o federal, em 2007, passando a compor o conjunto de imóveis do roteiro, bens que integram a primeira chancela brasileira de paisagem cultural no Brasil. A investigação apoiou-se em pesquisa bibliográfica e documental e registro fotográfico. Conclui-se que a patrimonialização da Casa Krüger foi um processo demorado e conflituoso. Atualmente é uma Central de Atendimento ao Turista e apresenta problemas de conservação.
Integrazione. Evoluzione del diritto? Integration. Development of Law? Integração. Evolução do Direito?
Authors: Morresi Ferdinando
Published: February 2019

In questo articolo cerco di descrivere alcuni elementi emergenti nelle politiche migratorie, rispetto alla cittadinanza, assumendo che il fenomeno sia rilevante per discutere il cambiamento di significato dello Stato di diritto coinvolto nel processo. Secondo alcune premesse hegeliane e schmittiane, l’analisi delinea che alcuni simboli adottati per governare le politiche di immigrazione e cittadinanza tendono a non fare alcuna differenza tra i due poli. Questo tipo di indifferenza simbolica viene valutato come un tradimento del principio di parità di trattamento e, allo stesso tempo, si stima che alcuni nuovi miti siano necessari per rinfrescare l’ordine legale e conferire ad esso un significato più profondo in termini di giustizia reale.
Prevalência de queilite angular em pacientes idosos hospitalizados Prevalence of angular cheilitis in hospitalized elderly patients
Authors: Rizental Paula Crystina de Campos , Segato André Vinícius Kaled , Schun Cassiana Nathalie Machado Majewski , Souza Paulo Henrique Couto , Couto Soraya De Azambuja Berti
Published: February 2019

Introdução: A presença de doenças bucais em idosos hospitalizados, como a candidíase, deve ser um alerta para diferentes condições sistêmicas. Objetivo: Avaliar a frequência de queilite angular em pacientes idosos hospitalizados, bem como o seu desenvolvimento e/ou progressão durante o período de internação e a sua associação com anemia e diabetes melito. Material e métodos: Trata-se de um estudo observacional e descritivo, cuja amostra foi composta por 100 pacientes internados em enfermarias de um Hospital Universitário na cidade de Curitiba, no período de fevereiro a outubro de 2016. Para registrar a presença de queilite angular, os pacientes foram examinados, por um único observador calibrado, em dois momentos: inicial, com no máximo 24 horas de internamento, e final, compreendendo um período de 72 horas após a primeira avaliação. Dados como anemia e diabetes melito também foram coletados por meio do prontuário médico e exame hematológico (hemograma). A análise estatística ocorreu por intermédio do teste qui-quadrado e do modelo de regressão de Poisson univariada. Resultados: Entre os 100 pacientes avaliados (média da idade de 71,34 ± 8,33 anos), um total de 15 pacientes apresentou manifestação clínica compatível com queilite angular. Do total de pacientes que apresentaram a lesão, 13 eram do sexo feminino e dois do masculino. Não houve significância estatística entre as variáveis. Conclusão: A prevalência de queilite angular foi de 15%. Apesar da amostra reduzida de pacientes que manifestaram clinicamente a queilite angular, em comparação ao total de pacientes avaliados, é de extrema importância realizar a prevenção, controle e tratamento de condições sistêmicas, além de orientações aos pacientes e cuidadores, a fim de reduzir taxas de morbimortalidade relacionadas à má higiene bucal.
Capacidade da dissolução tecidual do hipoclorito de sódio em diferentes concentrações Capacity of sodium hypochlorite tissue dissolution in different concentrations
Authors: Gomes Fábio De Almeida , Santiago Natália de Santiago , Sena Fernanda Magalhães de , Dias Rafaela de Albuquerque , Ferreira Claudio Maniglia , Rocha Victória Gomes Alves , Pappen Fernanda Geraldo
Published: February 2019

Introdução: O hipoclorito de sódio é uma das principais substâncias químicas auxiliares utilizadas no tratamento endodôntico pelo seu potencial antimicrobiano de amplo espectro e sua capacidade de dissolver matéria orgânica. Contudo essa capacidade pode sofrer variações de acordo com as concentrações da solução e a temperatura em que ela se encontra. Objetivo: Realizar um estudo comparativo e descritivo acerca da capacidade de dissolução tecidual do hipoclorito de sódio (NaOCl) em diferentes concentrações e temperaturas em amostras de tecido muscular bovino. Material e métodos: Amostras de tecido muscular bovino, com peso e forma determinados, foram imersas em 3 ml de hipoclorito de sódio, divididas em grupos experimentais de acordo com a temperatura ambiente – 25°C ou sob aquecimento de 40ºC – e subdivididas em grupos de acordo com a concentração da solução: 0,5%, 1% e 2,5% e 5%. As amostras foram avaliadas visualmente e a cada minuto, durante 5 minutos, devidamente pesadas em uma balança de precisão. Em seguida, observou-se até sua total dissolução. Resultados: Houve diferenças significantes entre a capacidade de dissolução tecidual do hipoclorito de sódio entre as diferentes concentrações testadas e a efetividade em relação ao aquecimento das soluções. Conclusão: Com o aumento das concentrações testadas verificou-se maior capacidade de dissolução das amostras de tecido muscular bovino. O aumento da temperatura das soluções mostrou maior efetividade na dissolução das amostras de tecido nas concentrações de 2,5% e 5%.
Medication-related osteonecrosis of the jaw (MRONJ) treated with piezosurgery – case report and review of literature
Authors: Perini Analicy Ticiani , Oliveira Greison Rabelo de , Seguin Fabiana
Published: February 2019

Introduction and Objective: Medication-related osteonecrosis of the jaw (MRONJ) is a recently described adverse effect associated with anti-resorptive and anti-angiogenic agents. The objective of this article is to report a case of MRONJ treated surgically using a ultrasonic device (piezosurgery). Case report: A 66 year-old female being treated with a bisphosphonate (alendronate) for more than 4 years developed MRONJ of the lower jaw after dental extraction. Two debridement attempts of necrotic bone tissue and primary intention closure with conventional techniques were performed, without success. Finally, treatment with antibiotics and piezosurgery leaded to disease remission. Conclusion: Even though more studies are needed to create a protocol that might include this therapeutic modality, specially when there was no success with conservative management or conventional treatment techniques, the use of ultrasonic devices is an option for treatment of MRONJ.
Targeted Radionuclide Therapy of Painful Bone Metastases: Past Developments, Current Status, Recent Advances and Future Directions
Authors: Dash Ashutosh , Das Tapas , Russ Knapp Furn F.
Published: February 2019

Bone pain arising from secondary skeletal malignancy constitutes one of the most
common types of chronic pain among patients with cancer which can lead to rapid deterioration
of the quality of life. Radionuclide therapy using bone-seeking radiopharmaceuticals
based on the concept of localization of the agent at bone metastases sites to deliver focal cytotoxic
levels of radiation emerged as an effective treatment modality for the palliation of symptomatic
bone metastases. Bone-seeking radiopharmaceuticals not only provide palliative
benefit but also improve clinical outcomes in terms of overall and progression-free survival.
There is a steadily expanding list of therapeutic radionuclides which are used or can potentially be
used in either ionic form or in combination with carrier molecules for the management of bone
metastases. This article offers a narrative review of the armamentarium of bone-targeting radiopharmaceuticals
based on currently approved investigational and potentially useful radionuclides
and examines their efficacy for the treatment of painful skeletal metastases. In addition,
the article also highlights the processes, opportunities, and challenges involved in the
development of bone-seeking radiopharmaceuticals. Radium-223 is the first agent in this class
to show an overall survival advantage in Castration-Resistant Prostate Cancer (CRPC) patients
with bone metastases. This review summarizes recent advances, current clinical practice
using radiopharmaceuticals for bone pain palliation, and the expected future prospects in this
field.
A New Approach for Cancer Immunotherapy Based on the Cancer Stem Cell Antigens Properties
Authors: Mahmoodi Shirin , Nezafat Navid , Negahdaripour Manica , Ghasemi Younes
Published: February 2019

Background:

Cancer stem cells (CSCs) are a rare population of tumor cells,
which play an important role in tumor initiation, progression, and maintenance. The
concept that cancer cells arise from stem cells was presented about 150 years ago.
Recently, this hypothesis was renewed considering the heterogeneity of tumor cells.
CSCs are resistant to chemo- and radio-therapy. Therefore, targeting CSCs could be a
novel and effective strategy to struggle with tumor cells.

Objective:

In this mini-review, we highlight that different immunotherapeutic approaches
can be used to target cancer cells and eradicate different tumor cells. The most
important targets are specific markers recognized on the CSC surface as CSC antigens
such as CD44, CD133, Aldehyde Dehydrogenase (ALDH), and SOX family members.
This article emphasizes recent advances in CSCs in cancer therapy.

Results:

Our results present that CSC antigens play an important role in tumor initiation,
especially in the cells that are resistant to chemo- and radiotherapy agents. Therefore,
they are ideal targets for cancer immunotherapy, for instance, in developing different
types of cancer vaccines or antibodies against tumor cells.

Conclusion:

The current studies related to cancer immunotherapy through targeting the
CSC antigens based on their properties are briefly summarized. Altogether, CSC
antigens can be efficiently targeted to treat cancer patients.
Antioxidant Effects of Oleuropein on Hydrogen Peroxide-Induced Neuronal Stress- An In Vitro Study
Authors: Kucukgul Altug , Isgor Mehmet M. , Duzguner Vesile , Atabay Meryem N. , Kucukgul Azime
Published: February 2019

Background:

Persistent oxidative stress can lead to chronic inflammation and
mediate most chronic diseases including neurological disorders. Oleuropein has been
shown to be a potent antioxidant molecule in olive oil leaf having antioxidative properties.

Objective:

The aim of this study was to investigate the protective effects of oleuropein
against oxidative stress in human glioblastoma cells.

Methods:

Human glioblastoma cells (U87) were pretreated with oleuropein (OP) essential
oil 10 µM. After 30 minutes, 100 µM H2O2 was added to the cells for three hours. Cell
survival was quantified by colorimetric MTT assay. Glutathione level, total oxidant capacity,
total antioxidant capacity and nitric oxide levels were determined by using specific
spectrophotometric methods. The relative gene expression level of iNOS was performed by
qRT-PCR method.

Results:

According to viability results, the effective concentration of H2O2 (100µM) significantly
decreased cell viability and oleuropein pretreatment significantly prevented the cell
losses. Oleuropein regenerated total antioxidant capacity and glutathione levels decreased
by H2O2 exposure. In addition, nitric oxide and total oxidant capacity levels were also decreased
after administration of oleuropein in treated cells.

Conclusion:

Oleuropein was found to have potent antioxidative properties in human glioblastoma
cells. However, further studies and validations are needed in order to understand
the exact neuroprotective mechanism of oleuropein.
Causes and Consequences of MicroRNA Dysregulation Following Cerebral Ischemia-Reperfusion Injury
Authors: Forouzanfar Fatemeh , Shojapour Mana , Asgharzade Samira , Amini Elham
Published: February 2019

Stroke continues to be a major cause of death and disability worldwide. In this respect, the
most important mechanisms underlying stroke pathophysiology are inflammatory pathways, oxidative
stress, as well as apoptosis. Accordingly, miRNAs are considered as non-coding endogenous RNA
molecules interacting with their target mRNAs to inhibit mRNA translation or reduce its transcription.
Studies in this domain have similarly shown that miRNAs are strongly associated with coronary artery
disease and correspondingly contributed to the brain ischemia molecular processes. To retrieve articles
related to the study subject, i.e. the role of miRNAs involved in inflammatory pathways, oxidative
stress, and apoptosis in stroke from the databases of Web of Science, PubMed (NLM), Open Access
Journals, LISTA (EBSCO), and Google Scholar; keywords including cerebral ischemia, microRNA
(miRNA), inflammatory pathway, oxidative stress, along with apoptosis were used. It was consequently
inferred that, miRNAs could be employed as potential biomarkers for diagnosis and prognosis, as
well as therapeutic goals of cerebral ischemia.
Mitochondrial Common Deletion Level in Blood: New Insight Into the Effects of Age and Body Mass Index
Authors: Ahmadi Mahboube , Golalipour Masoud , Samaei Nader M.
Published: February 2019

Background:

Age-related decrease in mitochondrial activity has been reported in several
tissues. Reactive Oxygen Species (ROS) produced from defected mitochondria lead to aging and
accumulate through time. However, studies about the mitochondrial DNA mutation level in blood
are contradictory. Other lifestyle factors may modify the effects of age in post-mitotic tissues such
as blood. The BMI represents the sum of the various lifestyle factors.

Objective:

We proposed that age, obesity and mtDNA deletion are three ROS producing factors,
which may interact with each other and induce senescence.

Methods:

In a cross-sectional study, 172 male and female volunteers without known mitochondrial
diseases were selected and the presence of common mitochondrial 4977bp deletion (ΔmtDNA4977)
evaluated using Nested-PCR.

Results:

Our results showed that a high percentage of samples (54.06%) harbor common deletion in
blood. Furthermore, both BMI and the ΔmtDNA4977 levels significantly decrease with age. The
chronological age, BMI and ΔmtDNA4977 reciprocally affect each other.

Conclusion:

Our data suggest that age affects purifying selection and BMI, which may influence
the relative level of the mtDNA common deletion in blood.
Study of the Feto-maternal Outcome in Occipito-posterior
Position at the Onset of Labor
Authors: Arya Shashi Bala , Sharma Anshu , Goel Jai K. , Sinha Mridu , Chaurasia Rajni
Published: February 2019

Introduction: Childbirth is considered one of the most rewarding and memorable experiences in a woman’s life. Labour is the process that leads to childbirth. Difficult labor, characterized by abnormally slow labor progress, is known as dystocia. Malposition refers to any position of the vertex other than flexed occipito-anterior (OA) one. It is a common obstetric belief that progression of labour is underpinned by fetal position.
Material and Methods: 100 term antenatal patients, 50 with occipito-posterior (OP), and 50 with an OA position, were included in the study admitted in the labor room from December 2015 to March 2017. After the recruitment of patients, detailed history, examination: general physical, per abdominal and per vaginal was done. All patients underwent ultrasonography to confirm the fetal position at the onset of labor. They were then followed up until birth to determine the outcome. The neonatal outcome was analyzed by Apgar score at 1,5 minutes of delivery, presence of caput succedaneum, and molding.
Results: Among total 100 cases, the proportion of vaginal delivery was more in OA group (74%) in comparison with OP group (42%). 40% of patients of OP group landed into cesarean delivery against 18% of patients of the OA group. 8% percent of patients had face to pubis delivery. The mean duration of labor is prolonged in study group i.e., 473.2 ± 1.84 minutes in the first stage, 29.4 ± 7.67 minutes in second stage and 5.70 ± 1.75 minutes in third stage vs. i.e., 376.8 ± 1.26 minutes in first stage, 24.79 ± 9.77 minutes in second stage and 5.20 ± 3.22 minutes in third stage of labor of control group.
Conclusion: The group with malposition showed prolongation of labor in comparison to OA position. A higher rate of cesarean delivery was observed in the study group because of preference for cesarean over instrumental delivery. The neonatal outcome was comparable in both groups. Only a few instrumental deliveries were noted because the art of instrumental delivery is dying in modern obstetrics.
Computed Tomography Correlation of Thoracic Lesions
with Transthoracic Fine Needle Aspiration Cytology And
Biopsy
Authors: Madhok Rajneesh , Gupta Ashish , Singh Lalit , Agarwal Tanu
Published: February 2019

Introduction: The study is an attempt to evaluate the sensitivity,
specificity, positive predictive value, negative predictive value,
p-value, and complications of CT guided thoracic interventions
fine needle aspiration cytology and core biopsy, which are used
for diagnosing benign and malignant thoracic lesions.
Material and Methods: The study included 102 patients
(87 males and 15 females) with age group ranged from 15 to 87
years. A total of 143 CT guided interventions (84 FNAC’s and
59 core biopsies) were performed in 102 patients. The tissue
obtained was sent to the laboratory for histopathological and
cytological analysis for a final diagnosis, which would contribute
to patient management.
Results: A ll 5 9 c ore b iopsies w ere s uccessful i n p rocuring
adequate tissue for histopathological analysis and the yield of
core biopsies was 100%. However, out of 84 FNAC’s, only four
were unsuccessful in procuring adequate tissue with a failure
rate of 4.8%. Postprocedural biopsy complications were only
three (2.1%), which were small pneumothorax. There were 75
malignant lesions and 23 benign lesions based on cytology,
and histopathology (4 were excluded due to inadequate
sample). There was good agreement between benign and
malignant lesions diagnosed on CT and that diagnosed by
pathology. The most common benign and malignant lesions
were granulomatous lesion and squamous cell carcinoma.
Conclusion: Percutaneous CT guided interventions like
core biopsy and fine-needle aspiration cytology are simple
minimally invasive procedures with good patient acceptance
and low morbidity and almost negligible mortality. CT guided
interventions should be performed early for diagnosis of
thoracic lesions.
Perceptions of Information and Communication Technology as Support for Family Members of Persons With Heart Failure: Qualitative Study (Preprint)
Authors: Allemann Hanna , Thylén Ingela , Ågren Susanna , Liljeroos Maria , Strömberg Anna
Published: February 2019

BACKGROUND

Heart failure (HF) affects not only the person diagnosed with the syndrome but also family members, who often have the role of informal carers. The needs of these carers are not always met, and information and communications technology (ICT) could have the potential to support them in their everyday life. However, knowledge is lacking about how family members perceive ICT and see opportunities for this technology to support them.

OBJECTIVE

The aim of this study was to explore the perceptions of ICT solutions as supportive aids among family members of persons with HF.

METHODS

A qualitative design was applied. A total of 8 focus groups, comprising 23 family members of persons affected by HF, were conducted between March 2015 and January 2017. Participants were recruited from 1 hospital in Sweden. A purposeful sampling strategy was used to find family members of persons with symptomatic HF from diverse backgrounds. Data were analyzed using qualitative content analysis.

RESULTS

The analysis revealed 4 categories and 9 subcategories. The first category, about how ICT could provide relevant support, included descriptions of how ICT could be used for communication with health care personnel, for information and communication retrieval, plus opportunities to interact with persons in similar life situations and to share support with peers and extended family. The second category, about how ICT could provide access, entailed how ICT could offer solutions not bound by time or place and how it could be both timely and adaptable to different life situations. ICT could also provide an arena for family members to which they might not otherwise have had access. The third category concerned how ICT could be too impersonal and how it could entail limited personal interaction and individualization, which could lead to concerns about usability. It was emphasized that ICT could not replace physical meetings. The fourth category considered how ICT could be out of scope, reflecting the fact that some family members were generally uninterested in ICT and had difficulties envisioning how it could be used for support. It was also discussed as more of a solution for the future.

CONCLUSIONS

Family members described multiple uses for ICT and agreed that ICT could provide access to relevant sources of information from which family members could potentially exchange support. ICT was also considered to have its limitations and was out of scope for some but with expected use in the future. Even though some family members seemed hesitant about ICT solutions in general, this might not mean they are unreceptive to suggestions about their usage in, for example, health care. Thus, a variety of factors should be considered to facilitate future implementations of ICT tools in clinical practice.
Development of a Web-Based Monitoring System for Power Tilt-in-Space Wheelchairs: Formative Evaluation (Preprint)
Authors: Campeau-Vallerand Charles , Michaud François , Routhier François , Archambault Philippe S , Létourneau Dominic , Gélinas-Bronsard Dominique , Auger Claudine
Published: February 2019

BACKGROUND

A power tilt-in-space wheelchair meets many clinical purposes, including pressure management, increased postural control, and pain management. However, there is a significant gap between the use of tilt as recommended by clinicians and its actual usage. A Web-based electronic health (eHealth) intervention, including a goal setting, monitoring, reminder, and feedback system of the use of power tilt-in-space wheelchairs was developed. The intervention incorporates behavior change principles to promote optimal use of tilt and to improve clinical postprocurement follow-up.

OBJECTIVE

This study aimed to conduct a formative evaluation of the intervention prototype to pinpoint the functionalities needed by end users, namely, power wheelchair users and clinicians.

METHODS

On the basis of an evaluation framework for Web-based eHealth interventions, semistructured interviews were conducted with power wheelchair users and clinicians. A content analysis was performed with a mix of emerging and a priori concepts.

RESULTS

A total of 5 users of power tilt-in-space wheelchairs and 5 clinicians who had experience in the field of mobility aids aged 23 to 55 years were recruited. Participants found the Web interface and the physical components easy to use. They also appreciated the reminder feature that encourages the use of the tilt-in-space and the customization of performance goals. Participants requested improvements to the visual design and learnability of the Web interface, the customization of reminders, feedback about specific tilt parameters, and the bidirectionality of the interaction between the user and the clinician. They thought the current version of the intervention prototype could promote optimal use of the tilt and improve clinical postprocurement follow-up.

CONCLUSIONS

On the basis of the needs identified by power wheelchair users and clinicians regarding the prototype of a power tilt-in-space wheelchair monitoring system, 3 main directions were defined for future development of the intervention. Further research with new wheelchair users, manual tilt-in-space wheelchairs, various age groups, and family caregivers is recommended to continue the formative evaluation of the prototype.
Translation of the Chinese Version of the Nomophobia Questionnaire and Its Validation Among College Students: Factor Analysis (Preprint)
Authors: Gao Ye , Dai Hongliang , Jia Guizhi , Liang Chunguang , Tong Tong , Zhang Zhiyu , Song Ruobing , Wang Qing , Zhu Yue
Published: February 2019

BACKGROUND

Nomophobia or phobia of no mobile phone is the fear of being without a mobile phone or being unable to contact others via a mobile phone. It is a newly emerging psychiatric disorder among mobile phone users.

OBJECTIVE

There are no psychometric scales available in China for examining nomophobia, although China has become the largest mobile phone handset consumer market in the world. Therefore, this study aimed to translate the original English version of a psychometric scale into Chinese and further examine its reliability and validity among Chinese college students.

METHODS

The original version of the Nomophobia Questionnaire (NMP-Q) was first translated into Chinese using the backward and forward translation procedure. An exploratory factor analysis (a principal component analysis plus varimax rotation) and a confirmatory factor analysis (CFA) were performed to examine the underlying factor structure of the translated questionnaire. The internal consistency reliability of the scale was determined by computing the Cronbach alpha coefficient, the test-retest reliability, and the corrected item-total correlation. A multivariate regression analysis was used for examining associations between nomophobia and independent variables among the college students.

RESULTS

A total of 2000 participants were included in the study. Their ages ranged from 16 to 25 years, with 51.95% (1039/2000) being male participants. The Chinese version of NMP-Q retained 18 items. The eigenvalues, total variance explained, and scree plot jointly support a 4-factor structure of the translated questionnaire. The CFA reached the adaptive standard, and the discriminant validity of the scale was good. The Cronbach alpha coefficient of this scale was .925, and the Cronbach alpha coefficients of the subscales were .882, .843, .895, and .818. The test-retest reliability was 0.947. Corrected item-total correlation ranged from 0.539 to 0.663. The significant predictors for each of the dimensions of nomophobia and total score of the questionnaire were the average number of hours spent on a mobile phone daily and gender.

CONCLUSIONS

The Chinese version of the NMP-Q exhibited satisfactory psychometric properties.