bluuebunny/crossref_metadata_2025 huggingface dataset:
Jedność a wierność w małżeństwie
Authors: Leszczyński Grzegorz
Published: August 2024

Artykuł jest próbą odpowiedzi na pytanie: czy jedność i wierność w małżeństwie oznaczają te same rzeczywistości, a w konsekwencji: czy wykluczenie wierności jest tym samym co wykluczenie przymiotu jedności węzła. Odpowiedź jest negatywna: dobro wierności małżeńskiej należy oddzielić od przymiotu jedności małżeństwa. Wykluczenie jedności oznacza, że kontrahent wyklucza zupełność oddania się małżonkowi, gdyż niemożliwe jest zobowiązać się do wierności w stosunku do wielu osób. Wykluczenie natomiast wierności małżeńskiej w środowisku monogamicznym ma miejsce wówczas, gdy kontrahent wyklucza prawo do wierności przynależne osobie współkontrahenta.
Pancasila Philosophy and Its Contribution to the Development of Golden Indonesia 2045
Authors: Masykur Zein Muchamad
Published: August 2024

It deliverables the role that Indonesia's basic philosophy, Pancasila, has played in carving out the development path of this country since it got its independence. The analysis would be mainly based on content data from some academic articles that deal with legal, political, and social issues in Indonesia, together with an overview of the implantation of Pancasila values into national development. The result of the study shows that Pancasila is very instrumental in guiding the progress and development of the Indonesian state. However, its actualization still faces various challenges, not least lack of public understanding, influence of globalization, and decreased emphasis on education. Optimizing the role of Pancasila towards "Golden Indonesia 2045" would consist of recommendations such as the education of Pancasila values, integration into governance, promotions of religious moderation, involvement of a young generation, and social media optimization. If these challenges are overcome, Pancasila will still be the foundation that underpins Indonesia's progress.
A produção de transgênicos e o problema da fome: perspectivas bioéticas para uma sociedade mais igualitária
Authors: Andrade William , Gervasoni Tássia Aparecida
Published: August 2024

A presente pesquisa possui o escopo de analisar a crise da insegurança alimentar, sob o ponto de vista das desigualdades sociais, em tempos de ampliação do uso da biotecnologia genética na agricultura e utilização de transgênicos na produção alimentícia. Nesse contexto, pretende-se responder se a produção agrícola em massa, por meio de técnicas de transgenia vegetal, pode resolver o problema da fome e contribuir para uma sociedade mais igualitária. Para tanto, será realizado um estudo sobre a crise da fome e das desigualdades sociais, com o objetivo de estabelecer conceitos e pressupostos comuns ao problema. Na sequência, serão apuradas as contribuições do avanço das políticas neoliberais para o agravamento da crise alimentar, bem como para a construção do discurso envolvendo os transgênicos. Ao final, sob a óptica da bioética, será feito um apanhado dos principais argumentos utilizados para a liberação comercial dos transgênicos, bem como seus benefícios e malefícios, a fim de se responder ao problema central da pesquisa. Por meio do método dedutivo e amparando-se na pesquisa bibliográfica, sobretudo em fontes secundárias, concluiu-se que os transgênicos ainda não conseguiram resolver o problema da fome no mundo, sendo que, quando aliados às influências do sistema econômico-financeiro atual, contribuem somente para o agravamento da problemática.
Cells, Genes and Data: Biobanks as Common Goods
Authors: Pinto Bustamante Boris Julián
Published: August 2024

Contemporary biomedical research, propelled by bioinformatics, has revolutionized the ex-ploration of the world through the collection and analysis of data from various biological materials. These advancements have given rise to ethical challenges, such as transformations in the practice of informed consent, issues related to privacy, equitable access to research benefits, and the privatization of genetic information. In this context, the governance of biobanks introduces ethical and legal tensions between liberal and communitarian perspectives. The privatization of biomaterials hinders global col-laboration and restricts the involvement of developing countries. Experiences of community-based governance in Norway, New Zealand, Argentina, and other cases suggest alternative models. Commu-nity-based governance of biobanks emerges as an ethical approach that acknowledges cultural values such as privacy, cooperation, and active community participation in decision-making.
MANAJEMEN HUBUNGAN MASYARAKAT BERBASIS DIGITAL UNTUK PENINGKATKAN PUBLIKASI DAN PENCITRAAN PONDOK PESANTREN SABILURROSYAD GASEK
Authors: Nurdi Muhammad Syifa'
Published: August 2024

The acceleration of information arising from the industrial revolution 4.0 has indirectly influenced organizations to compete to reach targets of organizational interests. On the other hand, in the face of the accelerated flow of information, the community realizes that they need a variety of quality information services. This phenomenon is an opportunity for organizations and public services to always provide interesting information to the public in order to improve their form of public relations and to improve the image of the organization or institution. Islamic boarding schools must not be apathetic in responding to this era of digital transformation. Islamic boarding schools must be able to follow this era, where information and communication technology is ingrained in society. Islamic boarding schools need to improve in order to implement digital-based public relations management. Digital information and communication media can be used by Islamic boarding schools to convey information such as profiles, vision and mission, facilities, programs, activities, and their advantages. This article discusses the use of technology as a form of public relations in Islamic boarding schools. Digital-based public relations management can be a big opportunity for Islamic boarding schools.
Role of Critical Realism in Uncovering Breastfeeding Experiences of Mothers Affected by Disaster and Displacement: Researcher’s Reflections
Authors: Hirani Shela Akbar Ali
Published: August 2024

Objectives:Ontology is a study of what is the reality or truth about a phenomenon. The ontological assumption of critical realism is grounded in the belief that human behavior, actions, and perceptions are shaped by a wide range of social structures and underlying mechanisms that are interrelated and complex. This article presents researcher’s reflections drawn from the findings of a study that used critical realism as a theoretical lens in exploring the breastfeeding facilitators and barriers of the internally displaced mothers in a low–middle-income country where natural disasters are prevalent and there is a dearth of research on factors that impede or facilitate breastfeeding practices of mothers during disasters and displacement.

Methods:Using critical realism as a theoretical lens, a qualitative study was undertaken in postdisaster settings of Pakistan. After seeking ethical approval, multiple methods were utilized to collect data, including field observation, document analysis, and in-depth interviews (40–60 minutes each) with 18 displaced mothers who were residing in temporary housing in northern Pakistan and facing struggles due to recurrent disasters in that region.

Findings:The findings suggested a wide range of structural factors at displaced mothers’ microsystems (maternal factors), mesosystems (sociocultural factors), exosystems (economic factors), and macrosystems (geopolitical factors) that directly and indirectly affect their breastfeeding practices during disaster and displacement. The findings uncovered the need for multilayered breastfeeding-friendly initiatives to promote, protect, and support breastfeeding in postdisaster settings. Some of these interventions include enhancing maternal knowledge on breastfeeding through awareness programs in local languages, clarifying myths and misconceptions surrounding breastfeeding, providing mental health and nutritional support to displaced mothers, creating breastfeeding-friendly spaces during disasters, offering culturally sensitive healthcare and humanitarian aid, empowering local people to promote breastfeeding culture, and restricting unmonitored donation of formula milk during disasters.

Conclusion:The ontological assumption of critical realism provided an opportunity to gain insight into a reality that is multifaceted, complex, and interrelated. A comprehensive understanding of a range of maternal, sociocultural, economic, and geopolitical factors from this study will help nurses, lactation consultants, breastfeeding advocates, service providers, and policymakers in developing context-specific interventions to improve breastfeeding practices and decrease child deaths during disaster and displacement. The findings hold implications for the future programs, practices, and policies to protect breastfeeding practices of mothers affected by disaster and displacement.
Financial Literacy and Risky Credit Behavior: The Moderating Effect of Minimalist Lifestyle
Authors: Pardo-Piñashca Eduardo
Published: August 2024

The minimalist lifestyle represents an opportunity to make more conscious consumption decisions that lead to higher well-being. In spite of its growing popularity among the younger generations, this lifestyle has received little attention from scholars. To address this limitation, the influence of the minimalist lifestyle on the financial decision-making process was examined. Particularly, the study investigated the moderating effect of the minimalist lifestyle on the relationship between financial literacy and risky credit behavior among 308 adults in Lima, Peru. Using partial least squares structural modeling, the results revealed that the adoption of the minimalist lifestyle strengthened the negative association between financial literacy and risky credit behavior. In other words, the minimalist lifestyle allowed the individual’s level of financial literacy to have a higher effect on risky behavior related to consumer credit only among individuals from Generation Y. What’s more, the application of artificial neural network allowed the identification of financial knowledge and financial behavior as the most important mitigators of risky credit behavior among Generation Y and Generation X individuals, respectively.
Determination of Teachers' Perceptions of Artificial Intelligence Concept: A Metaphor Analysis
Authors: Balıkçı Hasan Celal , Alpsülün Mustafa , Hayoğlu Gülseren
Published: August 2024

This research sought to explore educators’ views on Artificial Intelligence (AI), a topic that has become increasingly important with the advent of recent digital transformations. Given its potential impact on education, AI can offer valuable insights for curriculum planning and teaching strategies. The study used metaphor analysis to understand educators' perspectives on AI. An online questionnaire was employed to collect data from teachers working in schools affiliated with the Ministry of National Education in Şanlıurfa in the 2023-2024 academic year. Teachers were asked to complete the sentences about their perceptions of artificial intelligence, especially using expressions such as "Artificial intelligence is like ..." and "...because ...". According to the findings of the metaphor analysis, teachers conceptualized AI as a job facilitator, associating it with robots and machines representing cognitive intelligence. However, concerns also emerged about the potential risks of AI and its impact on creativity. The findings emphasized the complex perceptions of AI in education, showcasing the balance between its positive contributions and the ethical responsibilities it entails. While the study offers valuable insights for understanding the complexity of AI in the educational context, it also highlights the various metaphors teachers use to describe this technology. In this context, prominent metaphors used by teachers to describe artificial intelligence include human, robot, brain, assistant, and machine.
The Relation of Moodle-Based Self-Regulated Learning With Grade 11 Students’ Metacognitive Skills [Hubungan Self-Regulated Learning Berbasis Moodle Dengan Keterampilan Metakognitif Siswa Kelas 11]
Authors: Dethan Sipromia , Kevvin Kevvin , Nurtanto Levana Vivian
Published: August 2024

This research investigates the relation between Moodle based self-regulated learning and Metacognitive skills of grade 11 students in XYZ High School Tangerang, within the context of online asynchronous Applied Mathematics course. The research sample contained 105 students enrolled in this course. Researchers employed quantitative methods, collected data through survey questionnaires and analyzed it using correlation and linear regression methodologies. The results revealed a strong correlation (Pearson Correlation value = .619) between Moodle-based self-regulated learning and grade 11 students’ metacognitive skills in online asynchronous Applied Mathematics course in XYZ High School. The linear regression analysis indicated that Moodle-based self-regulated learning has a significant contribution towards students’ metacognitive skills as represented by the linear equation Y = 46.647 + 0.414X. This research makes an important contribution by how Moodle-based self-regulated learning can enhance students’ metacognitive skills in the context of online asynchronous Applied Mathematics course.
Le retour à vide des grumiers
Authors: Le Ray J.
Published: August 2024

Après avoir analysé les inconvénients du retour à vide d'une semi-remorque, l'auteur propose comme palliatif de charger la semi-remorque vide sur le camion. Il donne ensuite quelques informations concernant le remplissage du tracteur et de la semi-remorque. L'auteur décrit en détail l'installation d'un portique de chargement, pour la remorque, au point de déchargement des grumes et les opérations de chargement.
Chronique piscicole : la pêche dans la lagune Ebrié
Authors: Lemasson J.
Published: August 2024

Pas de résumé
The Effect of Using Digital Storytelling on Students' Listening Comprehension
Authors: Puspitasari Ayuni Iswiyana , Putra Bambang Arya Wija , Wahjuningsih Eka
Published: August 2024

This study is a quasi-experimental study using a post-test-only design. The purpose of the study is to determine if there is a significant effect of digital storytelling on the listening comprehension of eleventh-grade students. The population of this research was eight classeso f eleventh-grade students at SMAN 1 Kencong in the 2023/2024 academic year. Data was collected through a listening test. The data was statistically analyzed using a t-test with SPSS. Based on the results, the mean score of the experimental group (80.00) was higher than the control group (63.00). The significant (2-tailed) showed a value of 0.000 which was lower than 0.05. The results prove that there is a significant effect of using Digital Storytelling on students' listening comprehension on eleventh-grade students at SMAN 1 Kencong in the 2023/2024 academic year. Therefore, it is suggested to English teachers, students, and future researchers to use the results of this research as a reference.
Identifying Reading Difficulties and Strategies Among EFL Learners in Intensive Reading
Authors: Oktari Nimas Laras , Ariani Musli , Fitriyah Siti Masrifatul
Published: August 2024

Intensive reading helps students to understand the meaning of a word and is one of the college courses that is useful in learning. In this study, the researcher identified the difficulties and strategies used by EFL learners in intensive reading. The objective of this research was to identify the difficulties and the strategies used by EFL learners in intensive reading. The research used a qualitative case study that attempted to identifying reading difficulties and strategies among EFL learners in intensive reading. The researcher analyzed the data using thematic analysis model adopted from Braun and Clarke (2006). The result of this research showed that the students’ difficulties were divided into two types: reading difficulties related to learning goals and psychological barriers. When difficulties arise in the areas of learning objectives that students can use to guide their performance with these objectives, it can hinder students' reading comprehension. Studies also found that students face reading difficulties related to psychological barriers such as attention deficits, poor retention, lack of self-confidence, lack of motivation and shyness.  The result of this research is expected to be able to give meaningful contributions for, teachers or lecturers, EFL learners and other researchers.
Ensino remoto como esvaziamento do trato com o conhecimento da cultura corporal
Authors: Silva Nathália Carolina da , Alves Melina Silva , Santos Júnior Cláudio de Lira
Published: August 2024

Este trabalho analisou o trato com o conhecimento, participação e aprendizagem na disciplina de Educação Física, em uma escola pública de João Pessoa durante a pandemia, quando vigorou o ensino remoto. Participaram 13 estudantes que responderam a um questionário e um professor que, além disso, foi entrevistado. Foram utilizadas, para a análise dos dados coletados, as técnicas de estatística descritiva e análise de conteúdo, orientadas pela referência materialista histórico-dialética. Concluiu-se que, na realidade descrita, o ensino remoto reduziu de forma abissal as possibilidades de realização da tríade conteúdo-forma-destinatário e que a educação presencial garante, a cada pessoa, a possibilidade de enriquecer seus estudos nas complexas relações sociais próprias da prática social da humanidade.
Social Relations in Minangkabau Society from Hamka's Perspective in Tafsir Al-Azhar
Authors: Gazali Hidayatul Azizah , Auliya Sefri
Published: August 2024

Minangkabau is one of the cultures or ethnic groups in Indonesia that remains a popular subject for research from both cultural and religious perspectives. This is understandable given that the traditions within Minangkabau culture offer intriguing aspects for scholars to analyse. For instance, the matriarchal system in Minangkabau presents a paradox between the matrilineal perspective in culture and the patrilineal perspective in religion, showcasing the Minangkabau community's efforts to accommodate and reconcile cultural and religious approaches. This paper aims to explore the social relations within the Minangkabau community from Hamka's perspective as presented in Tafsir Al-Azhar. This study falls into the category of literary research with a qualitative approach. The data sources for this research are drawn from various library references, including the Tafsir Al-Azhar as the primary source and other related books as secondary sources. The data analysis method employed is content analysis. This research indicates that Hamka has a unique reading of social relations in Minangkabau, highlighting the distinctive influence of matriarchal/matrilineal practices on the social order of Minangkabau society. The explanation of social relations in Minangkabau exists in his tafsir as a tool to provide analogies or explanations of the meaning of verses, making them easier for readers to understand, considering that Tafsir predominantly has a social orientation.
Management of digital neuromas: an update on current nonoperative and operative interventions
Authors: Turner Acara , Woodberry Kerri , Taras John S.
Published: August 2024

Digital neuromas can be psychologically and functionally debilitating. While typically the result of penetrating traumatic injury, neuromas also stem from blunt trauma, chronic irritation, or prior inadequate repair. Abnormal axonal regeneration without an appropriate distal target following nerve injury results in the formation of end-neuromas, often leading to significant pain. Conservative management is centered around a combination of pharmacological interventions and therapeutic modalities. In the setting of failed conservative management, surgical intervention is employed with the goals of excising the neuroma and redirecting axonal growth into healthy tissue. This article focuses on painful digital neuromas and options for both nonoperative and operative management.
O “conceito” de identidade na obra “A Metamorfose”, de Kafka
Authors: Tapia José F. Castillo
Published: August 2024

Num mundo polarizado e em constante transformação, onde os vínculos sociais se tornaram mais superficiais, muitos jovens encontram dificuldade em estabelecer sua identidade. Nossa sociedade reflete a autorreferencialidade do consumismo, onde cada indivíduo trilha seu próprio caminho sem grande consideração pelo próximo. Por meio da obra “A Metamorfose”, de Kafka, e das metamorfoses vivenciadas pelo personagem principal, Gregor Samsa, que se transforma em um inseto e enfrenta situações absurdas, buscarei abordar o conceito de identidade utilizando termos da filosofia clássica, como essência, contingência e necessidade. Concluirei que a construção da identidade não ocorre exclusivamente no âmbito do eu, pois este se solidifica ao se fechar, ao se isolar. Por essa razão, a presença do Outro, a irrupção do estranho, desmantela essas barreiras, evidenciando que, no final das contas, todos nós somos Outros, essencialmente distintos uns dos outros. A dimensão ética desse entendimento nos leva a questionar: que tipo de mundo almejamos: um mundo restrito aos nossos semelhantes ou um mundo aberto a todos?
A Celebração dos Sacramentos numa Igreja Sinodal
Authors: Costa Rodrigo Ferreira da
Published: August 2024

A liturgia é por excelência o lugar da expressão da sinodalidade da Igreja. Na assembleia reunida pelo Santo Espírito para celebrar o memorial pascal de Cristo e, com Cristo, render louvores a Deus Pai, torna-se visível a unidade e a comunhão da Igreja, Povo de Deus. Pois, se a ação litúrgica da Igreja, pela força do Espírito Santo, tem o poder de transformar num só corpo, uma multidão de pessoas singulares, podemos afirmar que nela se expressa de modo visível a sinodalidade da Igreja, que na sua ministerialidade, forma um só Povo fiel de Deus, na participação, na comunhão e na missão. Nesse breve artigo vamos pontuar algumas questões que dizem respeito à celebração dos sacramentos numa Igreja sinodal, buscando compreender a liturgia como ação do Cristo-Igreja; a liturgia como expressão da sinodalidade da Igreja e, por fim, aceitar o convite para entrarmos na “escola” da Sagrada Liturgia e, aprender com ela, o caminho de uma Igreja sinodal.
Cuidado pastoral à luz da analítica do poder de Michel Foucault: problematizando uma prática política de governo das condutas
Authors: Oliveira Renato Carvalho de
Published: August 2024

Nos estudos de Michel Foucault sobre a matriz de poder que constitui os sujeitos do Ocidente, o poder pastoral, o cuidado aparece atribuído a líderes religiosos e políticos na pré-cristã metáfora do pastor. O poder pastoral é precisamente conduzir para um objetivo e, a um só tempo, intermediar a condução. Em decorrência disso, o cuidado emerge como uma prática de pastoreio. A hipótese do presente texto é que o cuidado concerne a uma prática paradoxal de poder, já que pode satisfazer necessidades e limitar a autonomia em situações-limite, para governar condutas. Nosso objetivo principal é a problematização da prática de cuidado desde a analítica do poder. Primeiramente, situaremos o poder pastoral na analítica do poder; em seguida, analisaremos a emergência do cuidado no pastorado oriental; na continuidade, faremos uma síntese dos traços distintivos do poder pastoral, ressaltando o cuidado como prática de governo; e, por fim, problematizaremos o paradoxo do cuidado na vida quotidiana. Na conclusão, apontaremos para o funcionamento paradoxal do cuidado, que, por um lado, inibe a autonomia dos sujeitos, e que, por outro lado, os promove como sujeitos social e politicamente autônomos.
Some Aspects of Differential Topology of Subcartesian Spaces
Authors: Chen Liuyi , Xia Qianqian
Published: August 2024

In this paper we investigate the differential topological properties of a subclass of singular space--subcarteisan spaces. First, we get further result on partition of unity for differential spaces. Second, we establish the tubular neighborhood theorem for subcartesian spaces with constant structural dimension. Third, we generalize the concept of Morse functions on smooth manifolds to differential spaces. For subcartesian space with constant structural dimension, we provide examples of Morse functions; With the assumption that the subcartesian space can be embedded as a bounded subset of an Euclidean space, we prove that smooth bounded functions on this space can be approximated by Morse functions; We study the infinitesimal stability of Morse functions on subcartesian spaces. Classical results on Morse functions on smooth manifolds can be treated directly as corollaries of our results here.
Construction finishes Materials and Innovations in the Global South
Authors: Babalola Olatunde , Ndimako Onyedikachukwu , Ekeh Eseoghene
Published: August 2024

Health resorts aim to create health sanctuaries, fostering an environment conducive to treatment, healing, and well-being. Material selection choices for health resort designers should comply with specific minimal requirements and criteria to provide a suitable atmosphere for health and wellness. Based on this assumption and some selection criteria, the study intended to analyse purposefully selected health resorts as the foundation for identifying acceptable materials to construct health resorts. This study had three main goals: to define the evaluated health resorts’ physical characteristics, determine their external works specifications, and investigate the material usage utilised in the interior of three primary functional spaces. We employed a case study approach as the qualitative research method.Top of Form Data was analysed using narrative and content analysis. According to the findings, natural materials, particularly those produced locally, are best suited for the outside and interior of health resort buildings. Wood is the most commonly used material, appearing in all instances studied. The findings are consistent with current worldwide trends toward environmentally friendly facilities. Adopting natural materials such as wood, stone, and soil for health resort planning would be practical, considering the health advantages of such environmentally friendly materials.
Location, Age, and Antibodies Predict Avian Influenza Virus Shedding in Ring-Billed and Franklin’s Gulls in Minnesota
Authors: Michalska-Smith Matthew , Clements Eva , Rasmussen Elizabeth , Culhane Marie R , Craft Meggan E
Published: August 2024

Influenza A Virus (IAV) is a multi-host pathogen maintained in water birds and capable of spillover into humans, wildlife, and livestock. Prior research has focused on dabbling ducks as a known IAV reservoir species, yet our understanding of influenza dynamics in other water birds, including gulls, is lacking. Here, we quantify morphological and environmental drivers of serological (antibody detection by ELISA) and virological (viral RNA detection by PCR) prevalence in two gull species: Ring-billed (\emph{Larus delawarensis}) and Franklin's (\emph{Leucophaeus pipixcan}) gulls. Across 12 months and 10 locations, we tested over 1500 gulls for influenza viral RNA, and additionally tested antibody levels in nearly 1000 of these. We find substantial virus prevalence and a large, nonoverlapping seroprevalence, with significant differences across age and species classifications. Body condition index had minimal explanatory power to predict (sero)positivity, and the effect of the surrounding environment was idiosyncratic. Our results hint at a nontrivial relationship between virus and seropositivity, highlighting serological surveillance as a valuable counterpoint to sequencing. By providing indication of both past infections and susceptibility to future infections, serosurviellance can help inform the distribution of limited resources to maximize surveillance effectiveness for a disease of high human, wildlife, and livestock concern.
Nail Lacquer with Origanum vulgare Essential Oil and Biogenic Silver Nanoparticles for Onychomycosis: Development, Characterization, and Antifungal Effectiveness
Authors: Scandorieiro Sara , de Oliveira Natalia Rodrigues , de Souza Monique , Castro-Hoshino Lidiane Vizioli de , Baesso Mauro Luciano , Nakazato Gerson , Kobayashi Renata Katsuko Takayama , Panagio Luciano Aparecido , Lonni Audrey Alesandra Stinghen Garcia
Published: August 2024

Onychomycosis is a common fungal nail infection for which new antibiotics are needed to overcome antifungal resistance and other limitations of conventional treatments. This study reports the development of antifungal nail lacquers containing oregano essential oil (OEO), rosemary essential oil (REO), and/or biogenic silver nanoparticles (bioAgNP). The formulations (F) were tested against dermatophytes by agar diffusion, ex vivo nail infection, and scanning electron microscopy techniques. They were evaluated pharmacotechnically and by FTIR-PAS to access permeation across the nail plate. F-OEO and F-OEO/Ag were promising for the final nail lacquer formulation, they permeated through the nail plate and showed antifungal efficacy against dermatophytes-contaminated nails after 5 days of treatment. The treated nails had decreased hyphae and spores compared to untreated control; the hyphae were atypically flattened which indicates loss of cytoplasmic content due to damage to cytoplasmic membrane. Formulations were stable after centrifugation and thermal stress, maintaining organoleptic and physicochemical characteristics. F-OEO and F-OEO/Ag had pH compatible with the nail, and drying time (59-90 s) within the reference for nail lacquer. For the first time, OEO and bioAgNP were incorporated in a nail lacquer, resulting in a natural and nanotechnological antifungal product for onychomycosis that may combat microbial resistance.
Are There Non-invasive Biomarker(s) That Would Facilitate the Detection of Ovarian Torsion? A Systematic Review and Meta-Analysis
Authors: Doherty Grace , Naylor Meg , Draper Hannah , Fletcher Daniel M , Rigby Alan , Adedipe Tolu , Guinn Barbara-ann
Published: August 2024

Ovarian torsion (OT) is a rare gynaecological emergency that requires a prompt diagnosis for optimal patient management. To determine whether there were any biomarkers suitable for the non-invasive detection of OT, two independent reviewers performed systematic searches of five literature databases following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Full-texts of 24 selected articles were assessed for risk of bias and quality assurance using a modified Newcastle-Ottawa Scale (NOS).  15 articles described studies on animals and all described serum biomarkers comparing results between OT versus a sham operation, a control group or readings before and after OT. Ischaemia modified albumin (IMA), serum D-dimer (s-DD), heat shock protein-70 (hsp-70), Pentraxin-3 (PTX-3) and c-reactive protein (CRP) showed the most promise, each with p-values for the difference between groups achieving ≤0.001. In studies of humans, the biomarkers ranged from 16.4-92.3% sensitivity and 77-100% specificity. The most promising biomarkers for the early prediction of OT in patients included s-DD, interleukin-6 (IL-6), IMA and tumour necrosis factor-alpha (TNF-. IL-6 had the highest sensitivity of any biomarker identified in this review and was raised in all 13 patients with proven OT, with values of ≥10.2pg/ml, indicative of a 16 times higher risk of having OT. Signal peptide, CUB domain and EGF like domain containing 1 (SCUBE1) had a high specificity at 93.3%, second only to s-DD and a positive likelihood ratio (LR)>10. IMA was the only other biomarker that also had a positive LR>10, making it a promising diagnostic biomarker. The studies identified by this systematic literature review each analysed small patient groups but IMA, DD and SCUBE1 nevertheless showed promise as serum biomarkers with a pooled LR>10. However, further well-designed studies are needed to identify and evaluate individual markers, or diagnostic panels to help clinicians manage this important, organ-threatening condition.
Germline Polymorphisms Associated with Overall Survival in Lung Adenocarcinoma: Genome-Wide Analysis
Authors: Minnai Francesca , Noci Sara , Esposito Martina , Schneider Marc A. , Kobinger Sonja , Eichhorn Martin , Winter Hauke , Hoffmann Hans , Kriegsmann Mark , Incarbone Matteo , Mattioni Giovanni , Tosi Davide , Muley Thomas , Dragani Tommaso A. , Colombo Francesca
Published: August 2024

Background/Objectives: Lung cancer remains a global health concern, with substantial variation in patient survival. Despite advances in detection and treatment, the genetic basis for the divergent outcomes is not understood. We investigated germline polymorphisms that modulate overall survival in 1,464 surgically resected lung adenocarcinoma patients. Methods: A multivariable Cox proportional hazard model was used to assess the association of more than 7 million polymorphisms with overall survival at the 60-month follow-up, considering age, sex, pathological stage, decade of surgery and principal components as covariates. Genes in which variants were identified were studied in silico to investigate functional roles. Results: Six germline variants passed the genome-wide significance threshold. These single nucleotide polymorphisms mapped to non-coding (intronic) regions on chromosomes 2, 3, and 5. The minor alleles of rs13000315, rs151212827, and rs190923216 (chr. 2, 3 and 5, respectively) were found to be independent negative prognostic factors. All six variants have been reported to regulate the expression of nine genes, seven of which are protein-coding, in different tissues. Survival-associated variants on chromosomes 2 and 3 were already reported to regulate the expression of NT5DC2 and NAGK, with high expression associated with the minor alleles. High NT5DC2 and NAGK expression in lung adenocarcinoma tissue were already shown to correlate with poor overall survival. Conclusions: This study highlights a potential regulatory role of the identified polymorphisms in influencing outcome and suggests a mechanistic link between these variants, gene expression regulation, and lung adenocarcinoma prognosis. Validation and functional studies are warranted to elucidate the mechanisms underlying these associations.
Surface and Mineral Changes of Primary Enamel After Laser Diode Irradiation and Application of Remineralization Agents: A Comparative In Vitro Study
Authors: Cîrdei Mihaela-Valentina , Margan Mădălin-Marius , Margan Roxana , Ban-Cucerzan Alexandra , Petre Ion , Hulka Iosif , Horhat Razvan Mihai , Todea Darinca Carmen
Published: August 2024

Aim: The purpose of this study is to evaluate the remineralization potential of primary teeth enamel after being exposed to different laser diode therapy. Methods: Ninety-six vestibular primary teeth enamel samples were divided into eight groups (n=12) with varying treatments: control (G1), CPP-ACP-fluoride varnish (G2), diode lasers at 980 nm (G3), 808 nm (G4), 450 nm (G5), 980 nm + CPP-ACP-fluoride varnish (G6), 808 nm + CPP-ACP-fluoride varnish (G7), and 450 nm + CPP-ACP-fluoride varnish (G8). Each sample was assessed using DIAGNOdent® at baseline, post-treatment, and post-pH cycle re-mineralization. SEM imaging was performed before and after treatment and following the pH cycle. Results: The results indicated that the 980 nm and 808 nm diode lasers, both alone and in combination with CPP-ACP-fluoride varnish, either maintained or increased the calcium (Ca) weight percentage (Wt%) in the enamel. The 980 nm diode laser combined with CPP-ACP-fluoride varnish (G6) showed a significant increase in Ca Wt%, suggesting a strong remineralization effect. Similarly, the 808 nm diode laser alone (G4) also promoted a substantial increase in Ca Wt%. In contrast, the 450 nm diode laser, whether applied alone or in combination with CPP-ACP-fluoride varnish, resulted in a lower Ca Wt% and an increase in phosphorus (P) Wt%. Most groups, except for the CPP-ACP-fluoride varnish alone (G2), demonstrated an increase in P Wt%, indicating a complex interaction between laser therapy and enamel remineralization. Conclusions: The combined use of laser therapy with CPP-ACP-fluoride varnish significantly enhanced the remineralization of temporary teeth enamel. The 980 nm diode laser + CPP-ACP-fluoride varnish showed the most pronounced improvement in remineralization, while the 808 nm diode laser alone also effectively increased calcium solubility. These findings suggest that higher wavelength diode lasers, particularly when combined with remineralizing agents, can effectively enhance the mineral content of primary teeth and promote enamel remineralization.
Severe Plastic Deformation Significantly Enhances Strengthening and Toughening Effect of T6 Treated 7046 Aluminum Alloy
Authors: Wu Yuna , Dong Hongchen , Huang Hao , Yuan Ting , Bai Jing , Jiang Jinghua , Fang Feng , Ma Aibin
Published: August 2024

7046 aluminum alloy has good fatigue property, corrosion resistance and weld property, but the moderate strength and plasticity limit its wider application and development. In the present study, severe plastic deformation (SPD) was applied prior to T6 treatment to significantly strengthen and toughen the 7046 aluminum alloy. Results indicate that the alloy processed by 4 passes of equal channel angular pressing (ECAP) at 300 ℃ prior to T6 treatment exhibits an excellent mechanical performance, with ultimate tensile strength (UTS) and elongation (EL) of 485 MPa and 19%, exhibiting an improvement of 18.6% and 375% compared to that of the T6 alloy, respectively. The mechanical properties of the alloy are further improved by the additional room temperature (RT) rolling process, with UTS of 508 MPa and EL of 23.4%. There are more precipitates of η' and Al6Mn phases in the 300℃4P-R80%-T6 and 300°C4P-T6 alloys, which contribute to the strengthening and toughening enhancement by SPD processed T6 alloy. The results of this work may shed some light on enhancing 7046 aluminum alloy.
Model Strengthening of Combined Wood and Concrete Pillar Foundations on Swamp Soil to Improve Stability and Durability
Authors: Agusniansyah Nursyarif
Published: August 2024

Swamp soil presents significant challenges for infrastructure development due to its soft and deformable nature, which compromises the stability of structures. Traditional wood pillars, while cost-effective and locally available, suffer from degradation caused by moisture and biological organisms. This study investigates various methods to strengthen wood pillars, focusing on the combination of wood and concrete pillars to enhance durability and load-bearing capacity in swamp soil environments. Laboratory experiments and field tests demonstrate that encasing wood pillars in concrete or using composite materials significantly improves their mechanical strength and resistance to deformation. The results highlight the potential of these techniques to provide sustainable and economical solutions for construction in swamp areas, ensuring greater stability and longevity of the infrastructure.
Standardized Method for Description of Cleft Lip and Palate Phenotypes and Its Implementation in Daily Practice
Authors: Vlahović Aleksandar , Stefanović Olivera , Mladenović Katarina , Vasić Miloš , Mijović Tanja , Miličković Maja , Rašić Petar , Đorđević Nemanja , Sinđić-Antunović Sanja , Dučić Siniša , Milanovic Filip , Zdujić Nenad , Nikolić Dejan
Published: August 2024

Cleft lip and palate are the most common congenital craniofacial anomalies. The etiology of this condition is unclear. The overall incidence of cleft lip and palate is 1/700. Prenatal diagnosis of cleft lip by 3D ultrasound is possible in more than 70% of cases, while it is less effective for cleft palate. There are several classifications of cleft lip and palate that were proposed over the years, however, only few have found clinical application, with none of them generally accepted as most effective and understandable. Allori et al. presented classification of a cleft lip and palate which is comprehensive and uniform, and it can precisely define the vast majority of the clefts, thus enabling easier communication between the health workers during their everyday practice. In this paper, we compared the accuracy of preoperative diagnoses compared to intraoperative diagnoses according to Kernahan and Stark classification from 1958, and these diagnoses were converted according to the Allori et al. classification of cleft lip and palate. Classification of cleft lip and palate presented by Allori et al. is clear, easy to understand, and it can be successful tool in studying the epidemiology of clefts.
The “Other” Workplace Design Factors: An Insight into What New Zealand Workers Want
Authors: Rotimi James Olabode Bamidele , Rasheed Eziaku Onyeizu
Published: August 2024

The recent COVID-19 pandemic has led to a reassessment of workplace necessities. It has resulted in the current shift from traditional workplace design to creating work experiences - a new par-adigm in workplace management. Hence, while some conventional workplace factors remain important to the experiences of workers and, thus, to their well-being, comfort and productivity, recent studies suggest other factors, not widely known, as important in creating the appropriate work experience. Our study explores these other factors in the workplace that contribute to, or may be very important to, workers’ comfort, well-being and productivity. These include working mode, facilities, sustainability practices and Diversity, Equity, and Inclusion (DEI) – cultural connection. A sample of 149 occupants across offices in New Zealand was conveniently collected for the study and analysed using descriptive and content analysis in SPSS vs 24. The results show that the occupants prefer to have private offices in the workplace and separate meeting rooms for better concentration on work. In terms of working mode, a combined model of remote working and in-office working is preferred. Furthermore, occupants prefer to have access control and fire safety systems essentially in the workplace and for their offices to be cleaned daily. For sustainable measures in the workplace, the respondents choose the following as practical and convenient: turning off computers outside work hours, using more LED light bulbs in the office, opening windows and doors when required and using a motion sensor lighting system. Interestingly, most of the respondents did not think having a cultural connection in their workplace was important. The study findings represent significant progress in identifying the needs of contemporary office workers. These findings assist facility managers and workplace designers in developing more proactive approaches to anticipated user issues in buildings.
Morphometric Differences in Sperm Subpopulations in Frozen-Thawed Semen of Two Bovine Subspecies
Authors: Sevilla Francisco , Araya-Zúñiga Ignacio , Silvestre Miguel A , Solís Juan , Barrientos Manuel , Dahl-Corcini Carine , Víquez Luis , Valverde Anthony
Published: August 2024

[Objetive] The objective of the present study was to characterize different sperm subpopulations based on morphometric parameters of frozen-thawed semen in two bovine subspecies using a CASA system. [Methodology] The experiment was carried out at the Costa Rica Institute of Technology from May to December 2023. Spermatozoa from 10 bulls (five animals of each species Bos taurus and Bos indicus) were evaluated after thawing of the semen doses by an ISAS®v1, computer-assisted sperm analysis (CASA)-Morph system. Sub-populations of head morphometric spermatozoa were characterized using multivariate procedures such as principal components (PCs) analysis and clustering methods (k-means model) [Results] The ejaculate of male exhibits significant heterogeneity and comprises diverse sperm subpopulations with differing morphometric patterns. Three different sperm subpopulations were identified from three PCs: t head size, head shape, and symmetry of the sperm head and the degree to which it was pyriform. The proportions of the different sperm subpopulations varied in the two-bovine subspecies; Bos taurus and Bos indicus. Results indicated that subpopulations SP1, SP2, and SP3 were different for PC criteria and these differences were relevant. The variability in sperm morphometry assessments underscores the need to standardize semen evaluation protocols [Conclusions] These findings highlight the importance of knowing the diversity in sperm morphometry between subspecies to both improve in vitro evaluation tests and to distinguish subspecies.
Optimizing Solar Potential Analysis in Cuba: A Methodology for High-Resolution Regional Mapping
Authors: Domínguez Javier , Bellini Carlo , Martín Ana María , Zarzalejo Luis F.
Published: August 2024

The development of solar energy on a regional scale necessitates a thorough understanding of available resources. Cuba, facing prolonged economic, environmental, and energy crises, urgently needs to enhance its sustainability through solar energy. While solar resource mapping is widespread, Cuba lacks extensive field measurements, often relying on models that may not be ideally suited for large regions like Matanzas province. Spanning over 12,000 km² with nearly 150 km between its northern and southern extremes, Matanzas presents challenges for high-resolution solar mapping. This study introduces a methodology that integrates various methods and databases to achieve maximum resolution in the resulting solar map. The approach is designed for large areas where conventional high-resolution models fall short. By optimizing calculation times and parameterizing the entire surface latitudinally, a high-resolution solar resource map for Matanzas has been developed. This map significantly enhances the understanding of solar resources in Cuba and proposes new methodologies for analyzing solar potential in similarly large regions.
Advances in the Treatment of Cognitive Impairment in Schizophrenia: Targeting NMDA Receptor Pathways
Authors: Zhang Ting , Liu Chang , Zhong Ning , Wang Yi-Chen , Huang Yi-Yun , Zhang Xiao-Qin
Published: August 2024

Cognitive impairment is a core feature of schizophrenia, playing a pivotal role in understanding the causes, processes, and outcomes of the disorder. Cognitive impairments in schizophrenia encompass a wide range of domains, including processing speed, episodic memory, working memory, and executive function. These deficits persist throughout the course of the illness and significantly impact functional outcome and quality of life. Therefore, identifying the biological basis of cognitive deficits in schizophrenia and developing effective treatments are imperative. The role of N-methyl-D-aspartate (NMDA) receptors in synaptic transmission and plasticity has long been recognized, making them potential targets for schizophrenia treatment. This review will focus on emerging pharmacology targeting NMDA receptor, offering strategies for the prevention and treatment of cognitive deficits in schizophrenia.