bluuebunny/crossref_metadata_2025 huggingface dataset:
O uso da força na narrativa de João Batista em Mateus 11
Authors: Olivares Carlos , Felipe Ribeiro Guilherme
Published: June 2022

Este ensaio enfoca a interpretação de Mateus 11:12, um conhecido dilema nos estudos mateanos. O verso, dependendo do jeito como os termos gregos biazō e biastēs são traduzidos, pode significar tanto “o Reino de Deus sofre violência” quanto “o Reino de Deus é tomado à força”. O artigo examina a passagem usando as lentes da crítica narrativa. Nos estudos bíblicos, a crítica narrativa surge como uma proposta literária de interpretação bíblica. Com uma visão centrada no texto, essa abordagem tem se provado ser significativa no estudo das narrativas bíblicas. O presente trabalho aplica o método de crítica narrativa proposto por Powell (1990) ao texto de Mateus 11:2-19, classificando elementos narrativos como cenários, personagens e eventos. O estudo também se utiliza de ferramentas exegéticas e linguísticas como proposto por Powell (1990), a fim de fornecer uma compreensão complementar de Mateus 11:12.
Management del paziente HIV positivo con infarto del miocardio: interazioni farmacologiche e ottimizzazione della terapia.
Authors: Pistarà et al. Eugenia
Published: June 2022

L’aumento dell’aspettativa di vita dei pazienti con infezione da HIV2 (PLWH) ha condotto a un’aumentata prevalenza di patologie legate all’invecchiamento. Nei soggetti con infezione da HIV da lungo tempo, queste patologie hanno come fattori di rischio aggiuntivi una viremia possibilmente non ben controllata all’inizio della loro storia clinica, e un eccesso di infiammazione persistente nel tempo, responsabile di un danno cronico del sistema cardiovascolare. Nel nostro centro sono seguiti oltre 750 pazienti, dei quali il 52,3% ha un’età superiore a 50 anni. Nel soggetto con infezione da HIV, spesso le patologie cardiache vengono mis-diagnosticate, i sintomi si manifestano in forma atipica o sono erroneamente associati alla patologia sottostante, con un ritardo diagnostico che può anche tradursi in esito infausto. In questo articolo abbiamo raccolto tre casi di PLWH con episodi di malattia cardiovascolare acuta che hanno presentato complicazioni legate alle interazioni farmacologiche tra farmaci antiretrovirali e farmaci per il trattamento e la prevenzione secondaria di malattia cardiovascolare. Con l’aumento dell’aspettativa di vita dei PLWH si dovrebbe tenere conto delle complicanze a lungo termine della ART, valutando preventivamente, quando possibile, regimi PI-sparing. Nel post-IMA è opportuno valutare tempestivamente le interazioni farmacologiche e la farmacocinetica, prediligendo molecole non metabolizzate dal sistema di enzimi CYP. È necessaria una collaborazione in tempo reale tra le differenti specialistiche mediche.
Nuova diagnosi di HIV con malattia avanzata: un’occasione mancata di diagnosi, una sfida multidisciplinare.
Authors: Bartalucci et al. Claudia
Published: June 2022

Una donna di 41 anni proveniente dal Camerun, con nuova diagnosi di infezione da HIV è giunta alla nostra attenzione con un quadro di insufficienza respiratoria acuta con necessità di ospedalizzazione.
In seguito agli accertamenti diagnostici, è stata classificata nello stadio CDC C3 per la presenza, come eventi AIDS-definenti, di polmonite da Pneumocystis jirovecii, candidosi esofagea, sarcoma di Kaposi cutaneo e viscerale, infezione disseminata da Mycobacterium avium complex, e infezione genitale da HSV2 della durata superiore a un mese. Alla diagnosi è stato riscontrato un HIV RNA di 9.6x104 copie/ml e CD4+ 6/mm3 (0. 5%), con rapporto CD4/CD8 pari a 0.0, quindi con uno stadio di infezione avanzato.
Mentre l’incidenza delle nuove diagnosi di HIV in Italia è in continua riduzione dal 2012, si è assistito dal 2015 ad un aumento delle diagnosi di retrovirosi in fase avanzata di malattia, come il caso qui presentato.  
Il ritardo nella diagnosi rappresenta una successione di "opportunità mancate" che ha condotto a una complessa gestione del quadro clinico in termini di interazioni tra farmaci, politerapia e necessità di frequenti controlli medici.
Inoltre, la presentazione di uno stadio avanzato di malattia ha reso più complesso, da un punto di vista psicologico e sociale, il percorso di accettazione della diagnosi e di presa in carico, con necessità di un approccio multidisciplinare.
Línguas indígenas de sinais
Authors: Soares Priscilla Alyne Sumaio , Fargetti Cristina Martins
Published: June 2022

Apresentamos um levantamento de línguas (ou possíveis línguas) indígenas de sinais encontradas hoje em uso no Brasil. É sabido que, além da Libras, o Brasil possui pelo menos duas línguas indígenas de sinais, que já puderam ser minimamente analisadas em suas estruturas: a língua de sinais Ka'apor (Kakumasu 1968; Ferreira-Brito 1984) e a língua terena de sinais (Sumaio 2014; Fargetti, Soares 2016; Soares 2018). Neste trabalho, não utilizamos o termo “língua emergente”, mas dividimos nossa classificação em: “línguas de sinais” e “possíveis” línguas de sinais. Esta classificação as respeita enquanto sistemas linguísticos, não importando a situação em que estejam. Sobre as “possíveis” línguas que estão sendo estudadas, citamos neste artigo: sinais dos Sateré-Mawé, sinais Guarani, sinais Kaingang da aldeia (SKA), os sinais Paiter-Suruí, os sinais dos Akwe-Xerente, línguas de sinais dos surdos pataxó do sul da Bahia, sinais usados por alunos moradores de zonas periféricas de Belém (região amazônica) e Ororubá. Além disso, queremos ressaltar que esses indígenas surdos devem ter seus direitos linguísticos e educacionais garantidos, e que já existem pesquisas sendo produzidas sobre essa temática.
Mercado de trabalho agrícola no Brasil
Authors: Sakamoto Camila Strobl , Maia Alexandre Gori
Published: June 2022

Em paralelo às mudanças institucionais do meio rural brasileiro, o setor agropecuário brasileiro passou por profundas transformações produtivas nas últimas décadas. Este artigo avalia a evolução da população de áreas rurais ocupada no setor agrícola com base nos dados dos Censos Demográficos de 1991, 2000 e 2010. Os resultados destacam que houve queda do número de ocupados agrícolas nos anos 1990 e aumento nos anos 2000. A geração do emprego agrícola nos anos 2000 abrangeu boa parte das áreas rurais. Aumentou também a inserção das mulheres no mercado de trabalho agrícola rural, atendendo em grande medida a demanda por mão de obra no setor. Por outro lado, diminuiu significativamente o número de empregadores agrícolas, fenômeno que pode estar associado à maior vulnerabilidade dos pequenos produtores e aumento da concentração no setor. Por fim, é importante destacar que a compreensão da evolução da população agrícola rural deve considerar a dinâmica demográfica local e suas perspectivas.
Educação escolar quilombola
Authors: Silva José Bezerra , Menezes Anderson de Alencar
Published: June 2022

Este artigo discorre sobre a educação escolar quilombola, comenta o processo de sua formação, características e paralelismo com a educação das relações étnico-raciais. Descreve sua importância no cenário da educação brasileira por ter como meta romper o silenciamento imposto aos quilombolas e ao mesmo tempo abrir espaços de diálogo com a emancipação iluminista, política e humana. A fim de dar efetividade a este desiderato, servimo-nos do método crítico-dialético que enxerga a situação contemporânea dos quilombolas articulada com o seu passado histórico e condicionada pelas movimentações socioeconômicas prevalecentes. Sua força emancipadora fica por conta da prática professoral.
Educação e epistemologias
Authors: Amaral Manoel Francisco do
Published: June 2022

O texto tem como objetivo desenvolver reflexão atualizada em relação à pedagogia das competências como tendência pós-moderna à luz da pedagogia histórico-crítica. É apresentado em três partes além da introdução e conclusão. Na primeira, pretende-se caracterizar a pedagogia histórico-crítica; segunda, algumas críticas à pedagogia das competências; terceira, revelar a relação entre a pedagogia das competências e a educação do estado de São Paulo; na conclusão, a necessidade urgente de resgatar a concepção de educação pautada na totalidade, superação da visão individualista, defesa dos interesses planetários e universais, as questões éticas, ambientais, justiça social e valorização da vida.
Educação e epistemologias
Authors: Sanchez Gamboa Silvio
Published: June 2022

Apresentação do n.1 (2022) da Revista Filosfia e Educação, dedicado à temática Educação e epistemologias. A organização deste número temático contou com a colaboração do Prof. Dr. Marcelo Donizete da Silva da |Universidade Federal de Ouro Preto (UFOP).  A seleção de trabalhos inclui nove (9) artigos diretamente relacionados com a temática proposta e que compõem a seção do dossiê e seis (6) artigos da seção de fluxo contínuo da revista Filosofia e Educação.
‘Ese pozo infesto hierve de vida’ o de cómo dos territorios se componen en impecable coincidencia
Authors: Medrano Celeste
Published: June 2022

Este artículo está inspirado en una anécdota de campo registrada durante un proceso de mapeo colectivo en comunidades Mbyá Guaraní. Reflexionando sobre la manera en que los indígenas y los no-indígenas conciben el paisaje, ensayamos la construcción de mapas y el diálogo sobre el territorio, incluyendo a agentes vinculados a la conservación y protección del ambiente. Los resultados nos revelaron los distintos vínculos que estos colectivos humanos tienen con el entorno. Concluimos que los indígenas y los “conservacionistas” componen territorios intersecados y sus interacciones encierran una plétora de desentendidos ontológicos que explican parte de las tensiones y los conflictos históricos.
Inovação educacional e escolha de saberes a ensinar em Escolas Kaiowá e Guarani em Mato Grosso do Sul
Authors: Ghanem Elie , Pellegrini Diana , Colman Rosa Sebastiana
Published: June 2022

Quem escolhe os saberes que as escolas indígenas ensinam? Responder a esta pergunta ajuda a compreender formas de exercício de poder que atravessam os processos sociais em que se negociam os sentidos compartilhados que a educação escolar pode adquirir. No caso indígena, esses sentidos podem ser afeitos à autodeterminação dos povos originários ou à manutenção da sua subordinação: assim, as conotações conferidas à escola podem visar ao enfrentamento e à superação da condição de dominação sob a qual indígenas têm participado na sociedade nacional, ou inversamente dar continuidade a relações colonialistas. Nessas premissas, o artigo descreve e analisa atores e condições que incidem sobre a seleção de saberes a ensinar em duas escolas de predomínio das etnias Guarani e Kaiowá, em que se detectaram práticas sociais regidas por uma lógica de inovação educacional. As informações coletadas levaram a concluir que os processos esboçam um multifacetado exercício de autonomia das comunidades, no qual se salienta a atuação dos corpos docentes indígenas.
Trastorno de ansiedad generalizada y estrés académico en estudiantes universitarios ecuatorianos durante la pandemia COVID-19.
Authors: Izurieta-Brito Daniel , Poveda-Ríos Santiago , Naranjo-Hidalgo Tamara , Moreno-Montero Esteban
Published: June 2022

La crisis sanitaria causada por el Coronavirus SARS-COV2 o COVID-19 incrementa sus niveles de contagio y deja millones de muertes, así como secuelas en la esfera psíquica de las personas afectadas. El confinamiento, la cuarentena obligatoria y las medidas usadas para reducir el número de contagios conllevan consecuencias negativas en la salud mental de los estudiantes universitarios. Objetivo: Identificar la relación entre estrés académico y el trastorno de ansiedad generalizada ocasionado por la pandemia COVID-2019. Material y Métodos: Estudio descriptivo-correlacional, empleando el Inventario Sistémico Cognoscitivo de Estrés Académico (SISCO) y la Escala para el Trastorno de Ansiedad Generalizada (GAD-7), aplicados a 359 estudiantes universitarios del Ecuador en el periodo Mayo-Junio 2020. Resultados: La muestra estudiada contó con 64,9% de mujeres y 35,1% hombres, con un 43,7% en el intervalo de edad 21 a 23 años. En SISCO, la media de estrés fue mayor en mujeres (X = 3,4313) vs. varones (X = 3,2142), ambos grupos mostrando niveles altos de estrés académico. Un 51.5% de mujeres y un 34,5% de hombres presentan además síntomas de ansiedad severa según GAD-7. La moderada correlación positiva entre estrés académico y ansiedad generalizada se reflejó en un rho = 0,68. Conclusiones: Existen niveles elevados de estrés académico en estudiantes universitarios, con mujeres como el grupo más afectado. Probandos de ambos sexos mostraron, en su mayoría, síntomas severos de ansiedad.
Manifestaciones cognitivas y neuropsiquiátricas de COVID-19 en el Adulto Mayor con y sin demencia: Revisión de la literatura.
Authors: Bombón-Albán Paulina E. , Suárez-Salazar Johanna V.
Published: June 2022

Durante la pandemia del síndrome agudo respiratorio severo por COVID-19, la demencia se ha identificado como desproporcionadamente común en los adultos mayores de 65 años que desarrollaron un cuadro viral grave. El Consorcio Internacional de infecciones respiratorias agudas graves y emergentes confirma una alta prevalencia de hospitalizaciones en adultos mayores con demencia. Esta sub-población presenta, en su mayoría, una variedad de comorbilidades, en particular, la fragilidad que puede exacerbar aún más el riesgo de infección muy severa. Además, hasta un tercio de los pacientes con COVID-19 pueden presentar secuelas cerebrales o neurológicas, efectos directos (infección viral de las neuronas, efectos vasculares) e indirectos (respuesta inmunológica del huésped, impacto del tratamiento). Esta revisión plantea la posibilidad de que la infección pueda acentuar cualquier enfermedad neurodegenerativa preexistente. Por otro lado, varios estudios han descrito que una proporción de pacientes presenta despues del alta hospitalaria, deterioro cognitivo, ánimo deprimido, ansiedad, insomnio y manifestaciones de trastorno por estrés postraumático. Enfermedades crónicas como la demencia está asociada con tasas más altas de hospitalización y mortalidad, y exacerba aún más la vulnerabilidad de los adultos mayores y el colapso en sus cuidadores.
TEKİRDAĞ’DA MODERNİZM İLE KARŞILAŞMALAR: MİMARLIK, BETON VE HARABE
Authors: ÖZDAMAR Esen Gökçe
Published: June 2022

Arapçada “eski yapı”, “yıkılmış, yıkılmaya yüz tutmuş yapı veya kent, yıkı”, Latincede ise “düşmek”

anlamına gelen ve ruere’den türetilen harabe (ruin), Rönesans’tan günümüze dek süblim, estetik, nostalji ve

yeni anlamlar üretme potansiyelleri bağlamında birçok düşünür tarafından ele alınmıştır. Modern harabe,

Sotomayor’un deyimiyle malzemenin değişim ve yok oluşuna tanıklık eden aktif bir katılımcıyı da yapının

yaşlanma ve ayrışmasına (material decomposition) dahil eden, zamanın askıya alındığı bir süreç yaratır.

Bu makale ise modernite ve harabe arasındaki ilişkilere değinerek bu ilişkileri Tekirdağ-Marmara Ereğlisi

karayolu üzerinde yer alan ve modernist dilleriyle ön plana çıkan, günümüzde ayakta kalabilmeyi başarmış

dört adet betonarme yapı üzerinden irdeler: 1960 ve 1980’li yıllarda inşa edilen Başak Sigorta Eğitim ve

Dinlenme Tesisleri, Şeker Sigorta Tesisleri, Güneş Sigorta Eğitim Tesisleri ve Bağkur Dinlenme Tesisleri.

2000’li yıllardan itibaren sahipleri tarafından atıl durumda bırakılan, yok olmaya karşı direnen ya da işlev

değiştirerek ayakta kalan bu yapılar, kıyı peyzajı içinde; yalın yerleşim planları, cephe düzenleri, piloti ve

rölyefleri ile izleyiciyi sahille ilişki kurmaktan çok çevrelerinden belirgin bir biçimde ayrımlaşma yaratır

ve “hem yapı olarak, hem de bir harabe olarak” var olmaya başlar. Böylelikle “her daim hayatta kaldıkları

izlenimi” yaratan bu modernist yapılar, beton ve harabenin çelişkisini gündeme getirir.
RESİM SANATINDA METAFİZİKSEL, FİZİKSEL VE RESİMSEL IŞIK ÜZERİNE BİR ARAŞTIRMA
Authors: AYDIN Serdar
Published: June 2022

Pilinius’dan Kübizm’e resim sanatında ışık konusu geniş bir tarihsel aralığı kapsamaktadır. Bu

süreç içinde, ışığın resim sanatında kullanımının üslupsal değişimlerin temel bileşenlerinden biri olduğu

görülmektedir. Bu geniş çerçevede ışığın, metafiziksel, fiziksel ve resimsel olmak üzere üç temel nitelik olarak

açığa çıktığı görülmektedir. Işık, bir fenomen olarak, doğa gözleminin ve onun resim yüzeyine aktarımının

asli bir unsurudur. Bu, ışığı fizik yasasına bağlı bir varlık olarak resmetmek anlamında fiziksel bir kullanımdır.

Rengin “temsil değeri”ne verilen anlam, ışığın ifadesini de bu değerin sınırları içerisinde bulmaktadır.

Metafiziksel kullanım ise resim tarihinde ışığın sembolik değerinin öne çıkarıldığı kavramsal bir boyutta ele

alınmıştır. Bu kullanım rengin hem “temsil değeri”ni hem de “özgül değeri”ni barındırabilmektedir. Resimsel

ışık kavramı ise, doğal ışık kavramından uzak, resim sanatının kendine has kurallarınca belirlenen bir

resimsel gerçeklik çerçevesinde anlam bulmaktadır. Ancak, bu üçlü dizinin, ışığın resim sanatındaki varlığını

nitelendirme ve sınıflandırma amacı ile indirgeyici bir yaklaşım ortaya koyması kaçınılmazdır. Çünkü,

ışığın resim sanatında kullanımları hiçbir zaman “resimsel ışık” konseptinin dışında değerlendirilmemiştir.

Metafiziksel ışık da fiziksel ya da doğal ışığın temsilinden tamamen farklı bir tarihsel sürece sahip değildir.

Bu nedenle ışığın resim sanatındaki tarihinin çizgisel bir tarih olmadığını; kavramların ise resim sanatının

pratikleri içerisinde birbirlerine açılan patikalarla geçişlilik gösterdiğini söylemek mümkün görünmektedir.
GRAFİK TASARIM ALANINDAKİ ETKİLERİ BAĞLAMINDA 21. YÜZYILDA YENİ BİR TASARIM ÜSLUBU OLARAK MAKSİMALİZM
Authors: EKER Cihangir , KIZGINDEMİR Can
Published: June 2022

Maksimalizm, 20. yüzyılın ikinci yarısından itibaren sanat ve tasarım literatüründe kendisine yer

bulmaya başlayan, çeşitli sanatsal akımların özelliklerini de içerisinde barındıran ve biçimsel olarak renkli,

canlı, zengin bir yapıya sahip olan üslubun adıdır. Bu üslup 21. yüzyılın ilk on yılından sonra özellikle grafik

tasarım alanındaki pek çok tasarımcıya ilham vermeye, aynı zamanda grafik tasarım ürünü talep eden

müşteriler tarafından daha çok istenilir olmaya başlamıştır.

Araştırmada 21. Yüzyılın ilk on yılından itibaren grafik tasarım alanında popülerleşen maksimalizm akımı

irdelenecektir. Bu doğrultuda araştırmanın problemi “Maksimalizm’in 21. yüzyıl itibariyle grafik tasarım

alanında sıklıkla tercih edilmeye başlanmasının sebepleri nelerdir?” olarak belirlenmiştir. Araştırma

problemi doğrultusunda araştırmanın amacının, maksimalizmin grafik tasarım alanında popülerleşmesinin

nedenlerini ifade etmek, ayrıca maksimalizme ilham kaynağı olmuş diğer sanat ve tasarım akımlarıyla

maksimalizmin ortak yönlerini belirleyerek akımın özelliklerini açıklamak olduğu söylenebilir. Araştırma

betimsel modele dayalı nitel bir çalışmadır. Araştırmada kavramsal çerçeveyi oluşturmak ve araştırma

problemini tartışabilmek amacıyla doküman incelemesi gerçekleştirilmiş, bu doğrultuda kitap, dergi,

e-dergi, tez, makale ve internet makalelerine başvurulmuştur. Araştırmanın, maksimalizm kavramına açıklık

getirmesi ve grafik tasarım literatürüne katkı sunması hedeflenmektedir.
GÖRSEL İLETİŞİM TASARIM EĞİTİMİNİN DEĞERLENDİRME SÜREÇLERİNDE ÜÇÜNCÜ GÖZ: BİR YAPAY ZEKÂ MODELİ
Authors: ERTÜRK Murat , ÜZÜMCÜ N. Erhan
Published: June 2022

Yapay zekâ hemen her alanda olduğu gibi tasarım alanındaki varlığını giderek artırmaktadır.

Tasarım disiplininde ise tasarımcıların mesleki hayatında meydana getirdiği değişimler ile tasarım üretimini

otomatikleştiren uygulamalar veya yazılımlarla adından söz ettirdiği görülmektedir. “Yapay zekâ bir tasarımı

ürününü değerlendirebilir mi?” sorusundan hareketle, tasarım eğitiminde yapay zekânın potansiyeli üzerine

fikir yürütmenin ve tartışmaya açmanın önemli olduğu düşünülmektedir.

Bu çalışmada, gözetimli öğrenme kullanılarak görsel iletişim tasarımı ve grafik tasarımı bölümü öğrencilerinin

logo tasarımlarının yer aldığı sınıflandırılmış veri seti ile CoreML uzantılı bir yapay zekâ modeli hazırlanmıştır.

Veri setinde bulunmayan, sınıflandırılmamış logo örneklerinin yer aldığı bir kontrol grubu oluşturularak

model test edilmiş ve yapılan deney sonucunda ortaya çıkan çıktılar aktarılmıştır. Yapay zekânın tasarım

ilkelerini öğrenerek estetik çıkarımlarda bulunma potansiyeli ve tasarım eğitimindeki ölçme-değerlendirme

süreçlerinde alabileceği role ilişkin öneriler getirilmiştir.
DESIGN FOR EMOTIONAL DURABILITY: THE CASE OF HOUSEHOLD LIGHT DESIGN
Authors: EREN Gizem Hediye
Published: June 2022

Designers’ hands-on experience in research through design process contributes them to produce and share knowledge from their own design practices. In this study, the primary purpose was exploring sustainable design concepts and developing solutions for improving the product lifespan of household light with research through design process. With a particular focus on “emotionally durable design”, “product personalisation”, and “localisation” were considered fruitful concepts. The do-it-yourself (DIY) approach, which means that users participate in production, and the halfway product rationale, which leaves space for users to complete the production, were the concepts used in personalisation. The outcome of the research through design process was a wall lamp manufactured with different scales of production, involving personalisation features facilitated by DIY and halfway product rationale. For “localisation”, different scales of production opportunities were explored, and a design kit as a halfway product was considered as a sustainable design solution. DIY approach was benefited for producing complementary lace lampshade. In the design for sustainability framework, it is seen that experimenting and engaging with locally available materials and manufacturing capabilities in the research through design process nurtured developing sustainable design solutions.
TAMPEREMANIN TARİHÇESİNE KISA BİR BAKIŞ
Authors: KALENDER Caner , AKGÜL BARIŞ Dolunay
Published: June 2022

Bu çalışma bir derleme makalesi olup, piyano ve sabit perdeli çalgıların akort sistemi olarak bilinen eşit

tamperemanın tarihsel gelişim sürecini incelemeyi amaçlamaktadır. Tampereman, kısaca müzikal aralıkların

doğal (Just Intonation) dizideki karşılıklarından belirli oranlarda değiştirilmesi şeklinde tanımlanmaktadır.

1300’lü yılların sonu itibariyle klavyeli çalgıların çoğunda seslerin tampere edildiği bilinmektedir. Yazılı

olarak tarifi yapılan ilk yöntem, “ara-ses” adı verilen tamperemandır. Bu yöntemde üçlülerin doğal veya doğala

yakın olmasına önem verilmiş, öte yandan beşliler bir miktar pesleştirilmiştir. Ara-ses tamperemanında bazı

aralıklarının aşırı tiz veya pes olması ve kullanılamayan tonalitelerin bulunması düzensiz tamperemanların

ortaya çıkmasına sebep olmuştur. Düzensiz tamperemanlarda aynı isimli birden fazla aralık bulunmasına

rağmen, tüm tonların kullanılabilir olması sebebiyle, bu yöntem iki yüzyıl kadar klavyeli çalgılarda

uygulanmıştır. Ara-ses tamperemanı ve düzensiz tamperemanlar kullanılırken dahi, eşit tamperemanın

önemi ve gerekliliği teorisyenlerin hep savunduğu bir konu olmuştur. Eşit tampereman 1570’li yıllarda

perdeli çalgılarda uygulanmaya başlamış, klavyeli çalgılarda ise çok daha geç tarihlerde kabul görmüştür.

1876 yılında Alexander J. Ellis’in ortaya koymuş olduğu cent sistemi eşit tamperemanın hesaplanmasında

dönüm noktasıdır. 20. yüzyılda uluslararası sanat müziğinde 12 ton müziğinin yaygınlaşması ile eşitsiz

tamperemanların sonu gelmiş, klavyeli ve perdeli çalgılar için ortak bir akort sistemi olarak kabul görmüştür.
Urethroplasty in a post irradiation urethral stricture - a review
Authors: Guerra Carlos , Davila Sergio , Pušica Slavica , Aleksic Predrag
Published: June 2022

Radiotherapy-induced urethral strictures (RIUS) decrease quality of life and present a great challenge for surgical reconstruction, especially due to proximal location, compromised vascular supply, and poor wound healing. It is unclear whether urethroplasty is an option in cases with stricture resulting from exposure to pelvic radiation. We review the pathophysiology, diagnostic workup, and disease-specific aspects of RIUS. Furthermore, we discuss several management alternatives such as excision and primary anastomosis, as well as techniques for open reconstruction with flaps. The most extensive techniques in the treatment of strictures include, for example, those using gracilis muscle flaps, as they can involve periurethral tissue to provide sufficient vascularity for excellent post-surgery urethral healing. In brief, RIUS represent a significant challenge. In carefully chosen patients, urethroplasty should be considered as a feasible and durable treatment. However, medical practitioners should always take into consideration that the results of urethroplasty in RIUS are not comparable to urethroplasties without a radiation background.
Aberrant calcium signalling downstream of mutations in TP53 and the PI3K/AKT pathway genes promotes disease progression and therapy resistance in triple negative breast cancer
Authors: Eustace Alex J. , Lee Min Jie , Colley Grace , Roban Jack , Downing Tim , Buchanan Paul J.
Published: June 2022

Triple-negative breast cancer (TNBC) is characterized as an aggressive form of breast cancer (BC) associated with poor patient outcomes. For the majority of patients, there is a lack of approved targeted therapies. Therefore, chemotherapy remains a key treatment option for these patients, but significant issues around acquired resistance limit its efficacy. Thus, TNBC has an unmet need for new targeted personalized medicine approaches. Calcium (Ca2+) is a ubiquitous second messenger that is known to control a range of key cellular processes by mediating signalling transduction and gene transcription. Changes in Ca2+ through altered calcium channel expression or activity are known to promote tumorigenesis and treatment resistance in a range of cancers including BC. Emerging evidence shows that this is mediated by Ca2+, modulation supporting the function of tumour suppressor genes (TSGs) and oncogenes. This review provides insight into the underlying alterations in calcium signalling and how it plays a key role in promoting disease progression and therapy resistance in TNBC which harbours mutations in tumour protein p53 (TP53) and the PI3K/AKT pathway.
High School Students' Misconceptions on Materials of Temperature and Heat Using Three-Tier Diagnostic Tests Assisted by Live Worksheets
Authors: Abdul Hakim Tita Tanggira, Lambang subagiyo,
Published: June 2022

This study aims to discover the misconceptions experienced by high school students on the material of temperature and heat. This type of research is descriptive quantitative. The sample of this research is XI science students at MAN 1 Samarinda and SMA Negeri 2 Samarinda, with 80 students. Research data were collected using tests. This type of test is a three-tier diagnostic test with three levels of answer choices, including questions and answer choices, reasons for answering, and confidence in answering. Overall, the results showed that students had misconceptions of 43.4%, which were classified as medium category misconceptions. Based on the misconceptions obtained, The misconceptions identified in the overall temperature and heat material are 43,36%, the percentage of understanding concepts is 34.75%, the percentage of only guessing is 8.67%, and the percentage of only guessing not understanding concepts is 13.08%. The percentage of misconceptions obtained includes the concepts of temperature and heat in the medium category level.
Analysis of Validation Results of Electronic Student Worksheet Based on Multi Representation of Linear Motion Kinematics Materials
Authors: Apriliana Lia , Ismet Ismet , Sriyanti Ida
Published: June 2022

Multi-representation-based electronic student worksheets are learning media with teaching materials that include verbal components, pictures, graphics, and mathematics. This study aimed to analyze the electronic student worksheet based on multi-representing valid linear motion kinematics material in high school physics class X. The research was conducted using Define-Design-Develop-Disseminate) model. Produce a valid product. There are two main aspects that we will analyze, namely: material and media. The results of the validation of the material aspects with indicators (1) content/breadth of material include material breadth, material depth, material truth, material completeness, material presentation, learning evaluation, and student activities with a percentage of 79% (valid), (2) Presentation of material that are covering techniques for presenting material, systematics, and generating motivation to learn with a percentage of 80% (valid), and (3) Language which includes sentence clarity, conformity with Indonesian language rules, and very valid status sentence structure with a percentage of 80% (valid). Meanwhile, the results of the analysis for the validation of media aspects with indicators (1) Didactic, which includes the learning process and ability development with a percentage of 80% (valid), (2) Construction which includes the accuracy of using language and sentences, paying attention to students' abilities, and has benefits, objectives, and identity with a percentage of 97% (very valid), and (3) Technical, said to be very valid by media experts on all indicators with a percentage between 97% (very valid). Based on the results of the analysis of the electronic student worksheet based on multiple representations, the media developed is valid. This media can analyze problem-solving skills in high school physics learning. This research is expected to reference other researchers in developing physics learning media.
Exploration of Physics Concepts in Milkfish Cultivation as An Ethnoscience Study in Sidoarjo
Authors: Citra Nina Fajriyah , Suprapto Nadi , Admoko Setyo
Published: June 2022

Indonesia has a cultural diversity embedded in the local wisdom of the region and has become an invaluable asset. Local wisdom is a form of native science of the community that has not been conceptualized scientifically but still can be a potential source of learning for students to study science as a form of ethnoscience. One of the local wisdom in Sidoarjo Regency is the milkfish, a city icon. This research aims to explore the concept of physics in milkfish cultivation. It can be developed to be applied in science learning in schools. This study is a qualitative descriptive study using observation methods and interviews directly with pond workers. In addition, researchers also conduct literature studies to strengthen the analysis of the data obtained. According to the findings, physical concepts are contained in the management system of milkfish ponds, including measurement materials, static fluids, dynamic fluids, thermodynamics, optics, and relativity.
Implementation of Multi-representation Learning on Climate Change Integrated Dynamic Fluid to Improve Student’s Problem-Solving Skills
Authors: Krisnaningsih Erina , Hariyono Eko
Published: June 2022

This research aims to analyze the implementation of multi-representation learning on climate change topics integrated fluid dynamics to improve students' problem-solving skills and analyze student responses to multi-representation learning on climate change topics integrated fluid dynamics. The type of this research is quantitative research with a pre-experimental that uses a one-group pretest-posttest design. This research was conducted in XI MIPA-1 at Senior High School 4 Sidoarjo with 36 students. Data collection techniques in this research used tests with test instruments in the form of description questions and questionnaires (responses) on a Likert scale. The data analysis technique is N-gain for the description test instrument and descriptive for student response questionnaires. The results of this research obtained the score of N-gain is 0.565 with a category of the medium. The results of student responses carried out using a Likert scale questionnaire for ten statements had positive and very positive results with a percentage of more than 77%. Thus, it was concluded that learning multi-representation could improve students' problem-solving skills with the topic of climate change integrated with fluid dynamics and elicit positive and very positive responses from students.
System approach to the underground construction objects planning based on foresight and cognitive modelling methodologies
Authors: Pankratova Nataliya , Pankratov Vladimir
Published: June 2022

The system approach to the underground construction objects planning based on foresight and cognitive modeling methodologies is proposed. Using the foresight methodology allows with the help of expert estimation procedures to identify critical technologies and build alternatives of scenarios with quantitative characteristics. For the justified implementation of a particular scenario the cognitive modelling is used, which allows to build causal relationships based on knowledge and experience, understand and analyze the behaviour of a complex system for a strategic perspective with a large number of interconnections and interdependencies. The suggested system approach allows planning of underground objects on the basis of reasonable scenarios selection and justification of their creation priority.
Hybrid GMDH deep learning networks – analysis, optimization and applications in forecasting at financial sphere
Authors: Zaychenko Yuriy , Zaychenko Helen , Hamidov Galib
Published: June 2022

In this paper, the new class of deep learning (DL) neural networks is considered and investigated — so-called hybrid DL networks based on self-organization method Group Method of Data Handling (GDMH). The application of GMDH enables not only to train neural weights, but also to construct the network structure as well. Different elementary neurons with two inputs may be used as nodes of this structure. So the advantage of such a structure is the small number of tuning parameters. In this paper, the optimization of parameters and the structure of hybrid neo-fuzzy networks was performed. The application of hybrid Dl networks for forecasting market indices was considered with various forecasting intervals: one day, one week, and one month. The experimental investigations of hybrid GMDH neo-fuzzy networks were carried out and comparison of its efficiency with FNN ANFIS in the forecasting problem was performed which enabled to estimate their efficiency and advantages.
Cognitive Radio Resource Scheduling using Multi agent QLearning for LTE
Authors: Sirhan Najem , Martinez-Ramon Manel
Published: June 2022

In this paper, we propose, implement, and test two novel downlink LTE scheduling algorithms. The implementation and testing of these algorithms were in Matlab, and they are based on the use of Reinforcement Learning, more specifically, the Qlearning technique for scheduling two types of users. The first algorithm is called a Collaborative scheduling algorithm, and the second algorithm is called a Competitive scheduling algorithm. The first type of the scheduled users is the Primary Users, and they are the licensed subscribers that pay for their service. The second type of the scheduled users is the Secondary Users, and they could be unlicensed subscribers that dont pay for their service, device to device communications, or sensors. Each user whether it is a primary or secondary is considered as an agent. In the Collaborative scheduling algorithm, the primary user agents will collaborate in order to make a joint scheduling decision about allocating the resource blocks to each one of them, then the secondary user agents will compete among themselves to use the remaining resource blocks. In the Competitive scheduling algorithm, the primary user agents will compete among themselves over the available resources, then the secondary user agents will compete among themselves over the remaining resources. Experimental results show that both scheduling algorithms converged to almost ninety percent utilization of the spectrum, and provided fair shares of the spectrum among users.
THE EFFECT OF EDUCATIONAL VIDEOS ABOUT NEWBORN BABY CARE ON THE KNOWLEDGE LEVEL OF POSTPARTUM MOTHERS
Authors: Purnamayanthi Pande Putu Indah , Adhiestiani Ni Made Egar
Published: June 2022

Background: The existence of the baby involves the mother's mechanical and emotional skills. Factors that can affect the mother's skills in caring for newborns are the mother's readiness to reduce the risk of the health of the newborn. Educational video is one of Health Education Methods that can be done to increase mother's knowledge in caring for newborns. The purpose of this study was to determine the effect of educational videos about newborn care on the level of knowledge of postpartum mothers.

Methods: This study was conducted in Badung, Bali in March to April 2022. The method used in this research is Pre-Experimental Design with one group pre-test and post-test design. Sampling method with purposive sampling technique.

Result: The results of data analysis using the Wilcoxon Match Pairs Test statistical test obtained p value = 0.000 < (0.05). Then there is a significant effect between the pre and post averages after being given the Newborn Care Education Video and the z value of 5.448 and the z table with a value of = 1.96 which means that z count is greater than z table which can be concluded that there is an Effect of Educational Videos on Newborn Care on the Knowledge Level of Postpartum Mothers.

Conclusion: The conclusion of this study is that giving a video of Newborn Care Education can increase Postpartum Mother Knowledge about Newborn Care.
In Situ-Forming Fibrin Gel Encapsulation of MSC-Exosomes for Partial-Thickness Rotator Cuff Tears in a Rabbit Model
Authors: Wang Chongyang , Tan Jiaqi , Zhang Yao , Chen Daoyun , He Yaohua
Published: June 2022

Background:

Current nonoperative treatments for partial-thickness rotator cuff tears (PTRCTs) have limited effectiveness in preventing tear progression or promoting tendon healing. This study aimed to establish a rabbit model using in situ-forming fibrin gel containing adipose stem cell-derived exosomes (ASC-Exos/fibrin) to treat PTRCTs.

Methods:

Fifty-six rabbits (112 shoulders) were included in this study and assigned to 4 groups: the control group (32 shoulders; PTRCTs without treatment), the fibrin group (32 shoulders; PTRCTs treated with fibrin gel), the ASC-Exo/fibrin group (32 shoulders; PTRCTs treated with ASC-Exos/fibrin), and the sham group (16 shoulders; sham surgery). Bilateral, 50%-thickness, bursal-side PTRCTs of 1 mm (depth) × 3 mm (width) × 5 mm (length) on the supraspinatus tendon were established by a number-11 scalpel blade, with accuracy of the measurement ensured by a digital vernier caliper. At 6 and 12 weeks postoperatively, gross observation, measurement of the thickness of residual supraspinatus tendons, and histological and biomechanical analyses were performed to analyze tendon repair.

Results:

At 12 weeks postoperatively, the tendon thickness in the ASC-Exos/fibrin group (mean and standard deviation, 1.63 ± 0.19 mm) was significantly greater than in the control group (0.85 ± 0.09 mm) (p < 0.0001) and fibrin group (1.16 ± 0.17 mm) (p < 0.0001). The histological score in the ASC-Exos/fibrin group (6.25 ± 0.53) was significantly better than in the control group (11.38 ± 0.72) (p < 0.0001) and fibrin group (9.00 ± 0.54) (p < 0.0001). Overall, immunohistochemical staining of types-I and III collagen and biomechanical testing also showed ASC-Exos/fibrin to be more effective in repairing PTRCTs than fibrin alone and no treatment.

Conclusions:

Local administration of in situ-forming ASC-Exos/fibrin effectively facilitated the healing of bursal-side PTRCTs in rabbits. This approach may be a candidate for the nonoperative management of PTRCTs.

Clinical Relevance:

Ultrasound-guided injection of ASC-Exos/fibrin may be a novel nonoperative strategy to treat PTRCTs.
Exposure-Related Anxiety and Improving Patient Satisfaction with Medical Undergarments During Surgery
Authors: Jacofsky Marc C. , Auran Richard L. , Williams Alyse , Mauro Susan , Sietsema Debra
Published: June 2022

Background:

The standard of care for patients undergoing a surgical procedure is to have patients remove all clothing and don a hospital-provided gown. A growing number of patients have anxiety when exposing their bodies in a medical setting, which increases stress for those patients.

Methods:

This study prospectively enrolled patients at a single orthopaedic specialty hospital into 1 of 2 garment groups in a block-randomized design. Patients were asked to remove all clothing; 100 patients received the standard-of-care gown only, and 100 patients received the standard-of-care gown plus a single-use undergarment designed with retractable panels and a releasable waistband. Patients completed surveys evaluating their levels of anxiety with regard to exposing their bodies in a medical setting.

Results:

There were 181 subjects (91%) who completed the preoperative surveys and 166 subjects (83%) who completed the post-discharge surveys. Fifty-seven subjects (31%) reported being uncomfortable exposing their private, intimate parts in a medical setting, and 39 subjects (22%) reported experiencing stress and/or anxiety related to body exposure. Ninety-seven patients (54%) agreed or strongly agreed that protecting their personal modesty is important when undergoing a medical procedure. More patients in the undergarment group agreed or strongly agreed that the garments provided by the hospital met their expectation for privacy (80 patients [87%]), compared with the standard-of-care group (65 patients [73%]) (p = 0.025). Patients in the undergarment group (36 patients [39%]) were more likely than those in the standard-of-care group (16 patients [18%]) to strongly agree that they were satisfied with the hospital-provided garments (p = 0.028). When asked if the hospital-provided garments would influence their choice of hospital, patients in the undergarment group agreed or strongly agreed 3 times as often (19%) as the standard-of-care group (6.6%) (p = 0.06).

Conclusions:

Exposure-related stress and/or anxiety are experienced by a substantial percentage of surgical patients, and the majority consider protection of their personal modesty in a medical setting to be important. The use of medical undergarments to protect modesty significantly increased levels of patient satisfaction.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
The geomorphological distribution of subaqueous tufa columns in a hypersaline lake: Mono Lake, U.S.A.
Authors: Keevil Claire E. , Rogerson Mike , Parsons Daniel R. , Mercedes-Martín Ramon , Brasier Alexander T. , Reijmer John. J.G. , Matthews Anna
Published: June 2022

Understanding the flow of carbon through hyperalkaline lakes is a key means of understanding their biogeochemistry, sedimentology, and their paleoenvironmental and paleoclimatic records. Furthermore, understanding how mineral precipitation is regulated in these lakes can provide insights into how their sequestration of carbon can be managed. We report geophysical surveys of Mono Lake, California, USA, which show unanticipated geomorphological control on the recent/contemporary formation of lacustrine carbonate formations (“tufa”). Acquired shallow-penetration seismic data show a fault zone below the lake floor, but despite the regional evidence for geothermal waters rising up these fractures, we find no evidence for tufa precipitation at the surface exposure of this structure, either in the seismic data or in the swath bathymetry. However, we do find sub-lacustrine tufa columns in these data elsewhere, which is the first time these have been reported directly. We find and report on a strong link between column location and meteoric Ca supply to the lake, with the latter sourced either through surface runoff or groundwater. For example, a region close to a creek inlet has more frequent and larger tufa bodies, which grow at a wider depth range than another region far from an inlet but close to the fault. This demonstrates the importance of meteoric water ingress in regulating carbonate mineral formation in these basins, and raises the possibility that management of water within the catchment could be a means to enhance carbon capture in natural and artificial hyperalkaline lakes.
Pulsed Electromagnetic Sounding of the Bazhenov Formation: High-Performance Computing to Justify a New Geophysical Technology
Authors: Epov M.I. , Nechaev O.V. , Glinskikh V.N. , Danilovskiy K.N.
Published: June 2022

—The work is devoted to the theoretical substantiation of a new geophysical technology for studying a unique geological object with unconventional hard-to-recover hydrocarbon reserves. The technology is based on transient electromagnetic sounding from a spatially distributed system of highly deviated wells drilled in target objects near the Bazhenov Formation. The results of computer modeling predetermine a new direction for geological exploration of unconventional hydrocarbon deposits. We consider a numerical solution to the 3D direct problem of pulsed electromagnetic sounding and, on its basis, develop a computational scheme and computer program. A mathematical model is built that describes the sensing process through a pulsed source for electromagnetic field excitation. The Fourier transform is used for time discretization, and the vector finite element method for spatial discretization. This approach makes it possible to obtain many independent 3D problems and effectively solve them in parallel by applying the modern multiprocessor technology. Using the KNL and Broadwell computing nodes of the Siberian Supercomputer Center SB RAS, we performed calculations of electromagnetic signals, which showed a high efficiency of the devised computing scheme and a high performance of the implemented algorithm. Despite the fact that the total peak performance of the KNL nodes is 2.5 times higher than that of the Broadwell nodes, their practical application for performing large-scale 3D modeling on the cluster shows a high efficiency of the latter. When choosing the most suitable computing architecture for the implementation of mass calculations, one should not rely on their formal characteristics only; significant performance is achieved taking into account the peculiarities of the computational methods employed for solving a specific problem. The implemented more efficient ways of performing parallel matrix-vector operations did not significantly increase the performance for this computational scheme. The created computational tools form the basis for further design of the configuration of a pulsed electromagnetic sounding system, and for identifying the capabilities of the new geophysical technology for examining complex geological media.