bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent Systems and Personalized Medicine: Regulatory Issues
Authors:   Associate Professor of the Department of Civil and Entrepreneurial Law of the Samara National Research University, PhD (Law), Associate Professor, Kryukova Elena S. , Inyushkin Andrey A. ,   Associate Professor of the Department of Civil and Entrepreneurial Law of the Samara National Research University, PhD (Law)
Published: September 2024

The article provides a comprehensive analysis of the problems of legal regulation of relations on the introduction and application of artificial intelligence technologies in the healthcare sector, including for the active promotion of breakthrough medical concepts and techniques. The authors propose to develop an approach that combines universal and sectoral legal regulation, in the context of which the regulatory framework in the healthcare sector should be based on the general principles reflected in the basic sectoral law, taking into account the specifics of medical activity. Within the framework of special legislation relating to certain medical areas, it is recommended to detail the algorithm for the implementation and use of intelligent systems.
Peteca de banana ou “petit gâteau”? Tradição, turismo e gastronomia
Authors: Chianca Luciana , Sales Josélio
Published: September 2024

Em Bananeiras, cidade paraibana que tem a banana no toponímico, canaviais disputam espaço com pomares historicamente cultivados por pequenos e grandes proprietários fundiários. Moradores e meeiros não tinham a autorização para plantá-los próximos a seus roçados, tornando excepcional o acesso às frutas para os mais pobres. Mesmo as abundantes bananas só eram consumidas por eles quando muito maduras e sua venda comprometida. Era quando cozinheiras anônimas e habilidosas transformavam-nas em petecas de banana; bolinho “mata-fome” oferecido preferencialmente às crianças. Reconversões produtivas conduziram Bananeiras ao turismo a partir dos anos 2000, quando cresceu o investimento simbólico de produtos “típicos” como a peteca de banana. Adaptada aos visitantes, ela se tornou gastronomia e foi declarada patrimônio oficial local. Este artigo busca compreender as transformações da peteca seguindo a memória de seu consumo socialmente diferenciado, focando nos diversos agentes da Rota Caminhos do Frio (2006), de significativa influência nesse processo.
Geographic Practice Preferences of Sexual Minority Allopathic Medical Students in the United States
Authors: Gupta Rachit , Rypka Katelyn J. , Fulk Travis , Lunn Mitchell R. , Obedin-Maliver Juno , Peebles Klint , Yeung Howa , Linos Eleni , Mansh Matthew
Published: September 2024

LGBTQ+ people face numerous healthcare disparities that vary geographically in the United States. LGBTQ+ physicians may be uniquely poised to address these disparities, but little is known about their geographic distribution. We performed a secondary analysis of a repeated, cross-sectional survey of graduating U.S. medical students—the 2016–2019 Association of American Medical Colleges’ Graduation Questionnaire—to assess geographic practice preferences of sexual minority (SM) medical students. We calculated the prevalence rates as well as crude and adjusted odds ratios using multivariable logistic regression analyses for intent to pursue practice in a specific region or urbanicity, or to practice outside the region of medical school attended. SM students (n= 3,645) compared with heterosexual students (n= 54,428) had higher odds of intending to practice in the Northeast or West and urban areas. They had lower odds of intending to practice in the South or Central regions and in suburban or rural areas. SM students compared with heterosexual students had higher odds of intending to practice outside their medical school region if they attended in the South or Central regions but not in the Northeast or West.
The Other Side of the Badge: Police as Victims of Violence
Authors: Hine Kelly , Davenport-Klunder Katelyn
Published: September 2024

When considering police within violence and victims research, the emphasis typically falls on the police as responders to victims; however, little research has explored the perspective of police officers as victims of violence themselves. Through a systematic literature review of contemporary assaults toward police, 11 empirical articles were identified and analyzed with four main themes emerging: the retaliatory nature of police–citizen dynamics, specific predictors of police assaults, environmental features of assaults, and the impact of assaults. These findings provide evidence-based insights, identify research gaps, and help guide future research agendas, ultimately providing a foundational resource for policymakers, law enforcement agencies, and researchers in developing targeted interventions and policies to enhance officers’ safety, foster positive police–community relations, and promote a safer and more resilient society.
Cluster Analysis in Victims of Perceived Cyberbullying at the Higher Education Level
Authors: Cervero Antonio , Bernardo Ana B. , Araújo Alexandra , Tuero Ellian
Published: September 2024

A number of studies have demonstrated the prevalence of cyberbullying in university settings. The objective of this research is to conduct a cluster analysis to categorize victims according to the nature of the behavior they have received and to examine the relationship between gender and intention to drop out. To this end, the Online Victimization Questionnaire was administered to a sample of 800 first-year students at a university in northern Spain who had opted to participate in the study. All analyses were conducted using the SPSS statistical software, version 27.0. Results indicate the presence of four clusters: Cluster 4 (73.625%) exhibited no instances of cyberbullying behaviors. Cluster 1 (21.875%), which exhibited low scores across all cyberbullying behaviors except identity manipulation, was the most prevalent. Cluster 2 (3.125%) demonstrated high scores for public aggression and social isolation. Finally, Cluster 3 (1.375%) exhibited high scores for all cyberbullying behaviors. Furthermore, gender differences play a significant role in the formation of these clusters. It is therefore evident that there are various profiles of cyberbullying victims, which both public policies and educational programs should be aware of in order to adapt their prevention strategies. This is also a factor that affects university dropout prevention programs.
Leaders’ Impact on Team Members Lacking Reasoning Skills for Creating Logical Working Environment
Authors: Singh Pushpender
Published: September 2024

Reasoning skills of the workforce are definitely factors in the performance of the modern competitive market. Without them, a team performs badly and seldom makes effective decisions. This paper discusses how business leaders can help address and enhance their teams' reasoning skills. Business leaders create a logical work environment and promote the cognitive skills of their teams to achieve improved outputs. The article presents ways in which leadership can be used deliberately to enhance reasoning. Supported by the scientific literature, this finding indicates that a leader can guide his co-workers to think better through giving advice and engaging them in critical thinking, which resulted in efficient and effective organizations. It provides an overall analysis of leadership techniques adopted and implemented in the leaders' site study area, along with their influence on the reasoning power of employees, for the benefits of business leaders.
The centennial of the “Zenit” review (1921–1926–2021): Examples of the avant-garde networking
Authors: Subotić Irina
Published: September 2024

“Zenit. International Magazine for New Art” (Zagreb–Belgrade 1921–1926), founded by philosopher, writer, poet and critic Ljubomir Micić (1895–1971), was the prominentavant-garde review with particular and attractive but often confusing ideas about the Balkanisation of Europe or Barbarogenius. The paper summarises the review’s positions and zenitist ideology, Micić’s activities established during the six years of its existence, as well as his international connections. “Zenit” was also considered to be an important magazine on the world avant-garde scene in the 1920s because of its wide spread collaboration and its particular, innovative and attractive typography and layout. The paper also presents the decentralised 2021 celebration of the centennial of the review’s first issue, with some important scientific publications, exhibitions and conferences held in Serbia, Croatia and Slovenia. The utopian construction Zeniteum, where arts and sciences meet, served as the basis for the solemn spectacle entitled Zeniteum: 2022, organised on the occasion of the proclamation of Novi Sad as the European Capital of Culture, in January 2022. Written and directed by Dragan Živadinov, this spectacle combined multiple experiences realised by various historical avant-garde movements in the world, including zenitism.
The 1st Exhibition of Polish Women Artists in Bydgoszcz: On the strategies of visibility on the cultural map of the reborn Second Polish Republic
Authors: Rosiejka Karolina
Published: September 2024

The text presents the background to the 1st Exhibition of Polish Women Artists, which took place in 1930 in the Bydgoszcz City Museum. The exhibition presenting only works by women is linked in the article to the social discourse of the Second Republic. It sought to build a progressive reborn Polish society based on the ideal of equality, including gender equality. The text proves that the 1st Exhibition of Polish Women Artists was aimed at raising the profile of the institution organising the event on the cultural map of Poland, and further, of the city itself, where the exhibition was held. The circumstances of the organisation of the exhibition and its resonance presented here make it possible to show the status of women’s art in the inter-war period, which evolved from a peripheral artistic reality into a phenomenon increasingly at the centre of art world manifestations.
Football, decathlon and the martial arts: The Axis Powers and the visual propaganda of the international mega sporting events: 1934–1940
Authors: Strożek Przemysław
Published: September 2024

The article focuses on the visual propaganda of international mega sporting events organized and planned by three countries, which would form the Axis Powers: Italy, Germany and Japan. These were the 1934 World Cup in Italy, the 1936 Berlin Olympics and the planned 1940 Olympic Games in Tokyo. Each of the three regimes developed a specific type of sport to be promoted by artists at the sporting events they hosted: football in Italy, a decathlon in Germany and martial arts in Japan. Despite fundamental differences in sporting topics and artistic styles, the depictions of athletes represented the militarist and imperialist ambitions of the future Axis Powers. What united some depictions of athletes around these events were fascist salutes performed by athletes, which testified to the visual mediation of the 1934, 1936 and 1940 international mega sporting events as simply fascist events.
L' agriculture et les agriculteurs chez Aristote
Authors: Helmer Etienne
Published: September 2024

Si Xénophon dans l’Économique et Platon dans les Lois prônent sans réserve l’intégration politique de l’agriculture et des agriculteurs, le cas d’Aristote dans les Politiques, c’est notre thèse, est différent. S’il fait de l’agriculture l’activité économique principale de toute cité juste pour des raisons à la fois empiriques et métaphysiques, la question de savoir qui doit l’exercer reste problématique : tandis que l’idéal serait à ses yeux que des esclaves ou des populations étrangères s’en chargent afin que les hommes libres se consacrent exclusivement aux affaires politiques, la réalité du monde grec conduit bien souvent les hommes libres à participer eux-mêmes aux tâches agricoles et à délaisser les fonctions politiques. En ce sens, les Politiques d’Aristote témoignent d’une intégration politique limitée et problématique des agriculteurs, entre inclusion et exclusion, et invitent à s’interroger sur la distribution et les relations des fonctions politiques et économiques dans la cité.
El vientre culpable
Authors: Montoya María del Pilar
Published: September 2024

Este artículo propone dar cuenta de la estrecha relación entre los fenómenos económicos que Platón describe y analiza en la República y ciertas prácticas relacionadas con la alimentación. Apoyándonos en los planteamientos del Timeo sobre los procesos fisiológicos relacionados con el procesamiento de los alimentos y en las consideraciones presentes en la Carta VII sobre los hábitos alimentarios, mostraremos que, además de su consciencia frente al rol ético y social de la alimentación, el filósofo reconoce en la diaita una operación económica y política en sí misma. En este sentido, además de aportar elementos nuevos a la reflexión de sus contemporáneos sobre la ética alimentaria, Platón es el primero en desarrollar una teoría según la cual la manera en que el hombre se alimenta define en gran medida la conducta económica de las ciudades y, por lo tanto, moldea su política.
Aristóteles y la justa proporción en las comunidades de intercambio
Authors: Martín Carlos Andrés
Published: September 2024

Este artículo analiza la noción aristotélica de τὸ ἀντιπεπονθός, entendida tradicionalmente como reciprocidad, y presenta una interpretación estrictamente matemática del tipo de justicia establecida para los intercambios comerciales en Ética Nicomaquea V 5. La justicia entendida como igualdad y, a su vez, como una media, le permite a Aristóteles exponer una concepción matemática alternativa a la pitagórica. Las escasas apariciones del término ἀντιπεπονθός y derivados aparecen en los Elementos de Euclides y resultan relevantes para comprender esta noción. Algunas definiciones del libro sexto y varias proposiciones permiten establecer con cierta certeza la correspondencia entre el esquema aristotélico y la recta dividida en extrema y media razón, también conocida como proporción áurea.
Exclusive breastfeeding and its association with pre- and postnatal factors
Authors: Melo Letícia Santos Alves de , Silva Lorena Fonseca , Silva Silvio Rocha Corrêa da , Rosell Fernanda Lopez , Valsecki Júnior Aylton , Zuanon Angela Cristina Cilense , Tagliaferro Elaine Pereira da Silva
Published: September 2024

Aim: This cohort study aimed to investigate the exclusive breastfeeding (EBF) prevalence and its association with maternal EBF intention and other variables. Method: Pregnant women (n=653) in the third trimester of pregnancy filled out a questionnaire on EBF intention using the Infant Feeding Intentions scale and other variables. After delivery, mothers were contacted by phone at the first (T1; n=467), third (T3; n=333), and sixth (T6; n=217) month of the baby’s life or until breastfeeding was terminated, to collect data on breastfeeding, delivery, the newborn, oral habits, and family variables. The associations between independent variables and the outcomes (EBF prevalence at T1, T3, and T6) were analyzed by simple and multiple logistic regression models (α =0.05). Results: EBF prevalence was 81.2% at T1, 64.0% at T3, and 35.9% at T6. Nott use baby bottle (OR=612.59; OR=139.08; OR=15.05) and no pacifier use (OR=2.94; OR=2.78; OR=2.93) were associated with the outcome at T1, T3, and T6, respectively. Other associated variables were strong EBF intention (OR=1.71) at T1; higher birth weight (OR=1.62), childcare support (OR=2.59), maternal age (OR=0.54), being married or having a partner (OR=1.82) at T3; and not returning to work (OR=2.39) at T6. Conclusion: The EBF prevalence was high at the first month of the baby’s life and decreased over six months. The EBF intention affected EBF initiation. Variables related to the mother´s demographic characteristics, the baby´s birth weight, the childcare support or the baby bottle/pacifier use were associated with EBF.
CBT EFFECTIVENESS FOR REDUCING PTSD: A META-ANALYSIS STUDY
Authors: Pratama Petrick , Yudiarso Ananta , Mami Kanzaki
Published: September 2024

PTSD terjadi pada individu yang telah atau sedang mengalami peristiwa traumatis. CBT adalah intervensi tanpa penggunaan obat yang dapat digunakan untuk mengurangi PTSD. Pembahasan yang bersifat konklusif seperti penelitian meta-analisis diperlukan untuk bisa menilai secara keseluruhan keberdampakan CBT terhadap PTSD. Penelitian meta-analisis dilakukan pada 14 jurnal penelitian yang diakses dengan menggunakan sarana peramban Google Chrome. Rentang waktu rilis publikasi yang akan dianalisis adalah pada kurun waktu 10 tahun terakhir. Sebanyak 898 partisipan terdiri dari 441 kelompok eksperimental dan 457 kelompok kontrol. Data dianalisis dengan menggunakan analisis statistik ukuran efek Cohen's d, hasilnya adalah mean (M), standard deviation (SD), dan ukuran sampel (N) untuk menghasilkan ukuran efek menggunakan efek campuran dengan Hedges'g sebesar 1,18, CI = 0,283 hingga 2,093 dengan nilai ketidaksesuaian (inconsistency value/I2) = 87,2%. CBT memiliki efek yang besar dalam mengurangi PTSD. Implikasi penelitian ini, peneliti dapat terus memberikan kontribusi dalam melakukan variasi CBT untuk PTSD.
PENURUNAN LOGAM Fe PADA PENGOLAHAN LUMPUR LIMBAH MENGGUNAKAN CACING LUMBRICULUS sp.
Authors: Afrianisa Rodu Dhuha
Published: September 2024

Lumpur hasil pengolahan limbah industri sering mengandung logam berat, polutan organik dan bakteri patogen. Fe (besi) merupakan logam yang bila dalam  jumlah besar di lingkungan dapat menyebabkan toksik. Pengololahan lumpur menggunakan cacing akuatik merupakan alternatif dalam mengurangi jumlah lumpur yang dihasilkan dari suatu instalasi pengolahan air  limbah.  Lumbriculus sp. mampu mengakumulasi logam secara biologis (bioakumulasi) yang selanjutnya dapat terjadi pengurangan logam berat dalam lumpur. Penelitian dilakukan dengan menambahkan cacing Lumbriculus sp. pada lumpur dari unit reservoir IPAL. Rasio berat cacing/lumpur dalam pengolahan yang digunakan adalah 0,4; 0,6; dan 0,8. Pengamatan penurunan kadar Fe pada lumpur dilakukan setiap hari selama 7 hari. Hasil dari penelitian ini menunjukkan adanya penurunan Fe pada lumpur pada hari ke 7 sebesar 15,44% rasio 0,6 dan 21,87% rasio 0,8. Terjadi perbedaan pada rasio 0,4 penurunan logam Fe sebesar 21,09% pada hari ke 6.
ANALISIS LIMPASAN PERMUKAAN DI SEKITAR KAMPUS UNIVERSITAS MUHAMMADIYAH SORONG KOTA SORONG
Authors: Farida Anif , Aryuni Vrita Tri
Published: September 2024

Daerah sekitar Kampus Universitas Muhammadiyah Sorong didominasi oleh kawasan terbangun dan menyisakan sedikit untuk vegetasi (pohon). Pembangunan lahan terbangun dan penutupan permukaan tanah dengan material yang diperkeras berpotensi menyebabkan tingginya limpasan permukaan (surface runoff) di daerah tersebut. Tujuan  penelitian ini adalah menghitung besarnya nilai koefisien aliran dan debit limpasan permukaan (surface runoff) yang ada di sekitar Kampus Universitas Muhammadiyah Sorong. Teknik analisis yang digunakan dalam penelitian ini adalah analisis kuantitatif. Nilai koefisien aliran ditentukan dengan rata-rata tertimbang dan berdasarkan penutup lahan. Debit limpasan permukaan dihitung dengan persamaan Rasional. Hasil penelitian menunjukkan bahwa koefisien aliran dipengaruhi oleh penutup lahan. Nilai koefisien aliran total sebesar 0,53 yang berarti 53 % dari hujan yang jatuh menjadi limpasan permukaan.  Debit limpasan permukaan paling tinggi pada kejadian hujan tanggal 17 Oktober 2019 sebesar 1,2 m³/detik dengan intensitas hujan 33,69 mm/jam, sedangkan  paling rendah tanggal 30 September 2019 sebesar 0,202  m³/detik dengan intensitas hujan 5,67 mm/jam.
Artificial Intelligence (AI) Literacy in Early Childhood Education: A Scoping Review
Authors: Solichah Novia , Shofiah Nurul
Published: September 2024

In the past decade, artificial intelligence (AI) literacy has become a primary focus in digital literacy education research. However, the use of AI in early childhood education (PUAD) remains largely unexplored, prompting experts to conduct a scoping review. This scoping review aimed to (1) explore various forms of AI application in early childhood education, and (2) identify commonly used methods in this topic. The database searches for scientific articles covered the period between 2016 to 2023. Inclusion and exclusion criteria were established, focusing on reviews related to AI literacy and early childhood education. Electronic databases such as Scopus, EBSCO Sciences, Emerald, Sinta, and Science Direct were used from December 2023 to February 2024. From the total of 260 articles selected for this analysis, only 10 met the inclusion criteria and were reviewed. The results showed that most articles used learning media tailored to children's developmental stages to enhance literacy. These included smart toys integrating AI technology, particularly speech synthesis, virtual reality, robots, KIERO, and chatbots. Qualitative methods were commonly adopted, although some research used experimental methods and literature reviews. In summary, the integration of AI literacy in early childhood education contributed significantly to the development of active learning interventions for children.
Through My Lens: Photovoice-Based Videos as Depression Anti-Stigma among Generation Z Students
Authors: Rachmania Firdhaniaty , Budiman Rizva Rahmadien Salama , Budiman Maharajni , Khairunnisa Larasati , Gunanagara Rival Muhammad Pangersa , Zakariyya Farhan
Published: September 2024

Depression is a mental issue closely related to the surrounding society, especially among Generation Z. The stigma associated with depression has led to several negative consequences, hindering life-long well-being. Developing an anti-stigma intervention regarding depression should be a collective concern. Therefore, this study aimed to investigate the effectiveness of photovoice-based videos as an anti-stigma intervention for depression. It included 29 Bandung-based Generation Z university students, using a pre-experimental design with one group pretest-posttest method. In this study, data were analyzed using normality tests, categorizations, and paired sample t-tests. The t-test results showed that the screening of photovoice-based videos caused a significant difference between pretest and posttest scores, confirming the rejection of H0 and the acceptance of Ha. Therefore, photovoice-based videos proved effective in reducing depression stigma among Generation Z university students in Bandung.
Is Fear of Missing Out Related to Neuroticism? A Meta-Analysis Study
Authors: Rahardjo Wahyu , Mardianti
Published: September 2024

The observation of the progress made in studying “fear of missing out” is interesting, specifically with a focus on analyzing the possible existence of a strong correlation between the concept and the antecedents widely involved in most of these studies such as neuroticism. This meta-analysis was conducted to measure the correlation between neuroticism and fear of missing out by considering the size of the effect. The process involved using 13,685 participants from 23 eligible studies as samples. The results showed that neuroticism was positively correlated to fear of missing out at a moderate strength as indicated by r = .369 and 95% CI (.29, .44). Similar results were also found for adolescents and emerging adulthood groups (95% CI [.272, .460]) as well as the common group and workers (95% CI [.249, .488]). Moreover, the heterogeneity test showed good significance, the distribution of scores was considered symmetrical except in adolescents and emerging adulthood, and no publication bias was detected. The moderate level of correlation reported showed the possibility of involving neuroticism as an antecedent of fear of missing out. However, the effect could become stronger when it was involved with other external antecedents.
Adapting the Copenhagen Burnout Inventory (CBI) Instrument for Elementary School Teachers Working with Gifted Students
Authors: Ludwina Gretta , Lubis Fitriani Yustikasari
Published: September 2024

The burnout phenomenon is prevalent in the teaching profession, and it significantly impacts teachers’ ability to cater to the unique needs of gifted students. Such burnout led to undesirable consequences for both teachers and students alike. A reliable instrument capable of measuring teachers’ burnout concerning gifted students’ education is necessary. The Copenhagen Burnout Inventory (CBI) is a suitable instrument for measuring burnout. It specifically focuses on pure exhaustion rather than considering burnout as a syndrome. However, this instrument has not yet been adapted to the Indonesian language. This study aimed to validate and determine the reliability of the Indonesian adaptation of the CBI. Content Validity Index (CVI) was utilized to assess the instrument’s validity, while Classical Test Theory (CTT) was employed to evaluate the reliability. A total of 76 elementary school teachers with experience in teaching gifted students were included in the research. The results showed that the adaptation of the instrument was valid and effectively measured relevant constructs related to burnout. The instrument exhibited a very high level of reliability, indicating strong dependability. Subsequent discussions should explore suggested adjustments for this adaptation, drawing insights from CTT findings.
Humility, Intellectual Humility, and Subjective Well-Being: The Mediating Role of Altruistic Attitudes and Prosocialness
Authors: Fahmi Abu Bakar
Published: September 2024

Previous studies have explored the relationship between humility and subjective well-being, but have given limited attention to the correlation between cognitive aspect of humility, known as intellectual humility, and subjective well-being. Understanding the underlying mechanisms that drive this relationship is essential. Therefore, this study aimed to investigate the relationship between humility, intellectual humility, and subjective well-being, with a focus on whether altruistic attitudes and prosocialness mediated the relationship. An online questionnaire was administered to a total of 231 participants to assess their levels for these variables. The results showed that prosocialness mediated the relationship between humility, intellectual humility, and subjective well-being. However, the hypothesized mediation effect of altruistic attitudes was not supported. In conclusion, the results indicated that high levels of humility and intellectual humility in an individual could increase prosocialness, which in turn, enhanced subjective well-being.
Structural Validity of Eureka Interest Inventory among Indonesian High School Student: An Analysis on Holland's RIASEC Model
Authors: Cucu Taqyah  , Akhnaf Ardhito Faza , Dumbi Khairunnisa Syafira
Published: September 2024

High school students are in the process of discovering their self-awareness. However, at this age, many high school students face confusion in making decisions about their vocational interest at their school, choosing between natural and social sciences. In response, the Eureka Interest Inventory (EII) was introduced and developed to assist students in measuring their vocational interests and abilities related to work activities based on the RIASEC Holland model. Therefore, the present study aims to assess the structural validity of the RIASEC Holland model among high school students and to determine any differences in validity based on gender and academic major. The sample population comprised 1609 high school students aged 17-19 years old. The validity of the measurement tool was evaluated using The Randomization Test of hypothesized Order Relations (RTOR) and analyzed using RStudio software. Additionally, the study used the Multidimensional Scalling (MDS) technique to describe the position of each RIASEC Holland personality type in graphical form. The results showed that the RIASEC Holland model has a good fit with the observed data. Additionally, no significant variations were observed in the fit of the model between male and female students, as well as between students majoring in natural and social sciences.
Why did numerical weather forecasting systems fail to predict the Hurricane Otis’s development?
Authors: Guillermo-Montiel Juan Carlos , Martínez-López Benjamín , Ochoa-Moya Carlos Abraham , Quintanar Ignacio Arturo , Cabos-Narváez William David
Published: September 2024

Hurricane Otis (HO) occurred in the eastern tropical Pacific (ETP), intensifying rapidly and unexpectedly, making landfall near Acapulco at 06:25 UTC on October 25, 2023 as a category five hurricane. Official and unofficial national weather forecasts (NWF) failed to predict HO’s development, trajectory, and intensification. To analyze the reasons for the failure of the NWF, we conducted two experiments using the Weather Research and Forecasting (WRF) model, with Global Forecast System (GFS) and fifth-generation ECMWF atmospheric reanalysis (ERA5) data as initial condition (IC). Our results showed that some fields in the GFS data, such as relative humidity, convective available potential energy, and even sea surface temperature, were more favorable for the development and intensification of the disturbance compared to ERA5. However, the three-dimensional structure of the wind field in the ETP in GFS did not contribute to the initial development of HO. Additionally, we explored the WRF’s sensitivity to different model configurations to simulate the trajectory and intensity of the hurricane using a coupled ocean-atmosphere system composed of WRF and a three-dimensional upper-ocean circulation model based on Price-Weller-Pinkel. Our numerical experiments involve modifications in the IC, cumulus parameterizations (CP), roughness coefficients, spatial resolutions, different time steps, and an idealized coupled model. The sensitivity test reveals the significance of the CP scheme, where the Kain-Fritsch was the only one that helped simulate the HO properly, altogether with increased spatial resolution. Furthermore, ocean-atmosphere coupling improves the prediction of the landfall time and location of the HO. However, no experiment captured the intensity or rapid intensification of HO.
Peptide-Functionalized Polymeric Nanoparticles for Delivery of Curcumin to Cancer Cells
Authors: Rostami Neda , Ghebleh Aida , Noei Hadi , Salimian Zahra , Moeinzadeh Alaa , Nikzad Abuzar , Gomari Mohammad Mahmoudi , Uversky Vladimir N. , Tarighi Parastoo
Published: September 2024

Polymeric nanoparticles (NPs) have garnered significant interest due to their potential in drug delivery. Specifically, nanopolymers functionalized with molecules such as proteins or peptides serve as versatile vehicles for this purpose. Curcumin (Cur) is a widely studied anticancer compound known for its positive effects on human health. Nevertheless, its insolubility and low bio-distribution hinder the exploitation of its beneficial traits. In this study, our team developed a nanodelivery system using a nanopolymer called poly(ε-caprolactone)-poly(ethylene glycol) (PCL-PEG), functionalized with A6 peptide to enable targeted delivery of Cur. The designed system exhibited favorable characteristics, including a stable zeta potential of -13.8 mV, a small size of 76.4 nm, uniform surface morphology, and high hydrophilicity with a contact angle of 31.53°. Additionally, the targeted delivery system demonstrated high encapsulation efficiency (EE%) (93 ± 0.89%), drug loading (DL%) (16.7 ± 0.9%), and a slow and gradual release profile with a release of approximately 83.1 ± 0.12%. The MTT assay results showed significant cell death in MDA-MB-231 cancer cells (IC50 = 21.3 ± 1.57 µM) when treated with the Cur-NPs-A6 formulation, while the toxicity of the designed NPs was reduced on non-cancerous MCF-10A cells. Moreover, both the RT-qPCR and invasion assays demonstrated the system's effectiveness in activating apoptosis pathways and inhibiting cell invasion. These findings suggest that the engineered intelligent delivery system, equipped with the A6 peptide, which has a strong affinity for CD44 (a protein with increased expression in malignancy), could be an exceptionally effective strategy for cancer treatment.
Targeting Clonal Mutations with Synthetic Microbes
Authors: Renteln Michael
Published: September 2024

Recently concluded, large-scale cancer genomics studies involving multiregion sequencing of primary tumors and paired metastases appear to indicate that most patients have one or more “clonal" mutations in their tumors. Clonal mutations are those that are present in all of a patient’s cancer cells. Clonally mutated proteins can potentially be targeted by inhibitors or E3 ligase glues, but developing new small molecule drugs for each patient is not feasible currently. One company is using an immunotherapy approach to specifically target clonal mutations. Another is using a different immunotherapy tactic that targets clonal and subclonal mutations. A third is planning to use a self-amplifying mRNA-based vaccination approach to target clonal mutations. To address the potential limitations of immunotherapy, I have devised another approach for exploiting clonal mutations, which I call “Oncolytic Vector Efficient Replication Contingent on Omnipresent Mutation Engagement” (OVERCOME). The ideal version of OVERCOME would employ a bioengineered facultative intracellular bacterium. The bacterium would initially be attenuated, but (transiently) reverse its attenuation upon clonal mutation detection.
Bioactive Factors Isolated and Purified from Bovine Colostrum Can Restore Extracellular Matrix under Degradation by Metalloproteinases
Authors: Coppa Federica , Giuffrida Graziella , Iannello Giulia , Pennisi Stefania , Ferruggia Greta , Brundo Maria Violetta
Published: September 2024

The ECM is composed of a considerable number of biochemically and structurally diverse constituents. ECM is a highly dynamic system that constantly receives and sends biological, chemical and mechanical signals. Several studies suggest that mechanical signals derived from the extracellular microenvironment regulate skin regeneration and wound healing. We evaluated effects of a mixture of biomolecules extracted and purified from bovine colostrum on restoring the mechanical properties of ECM. Test measuring collagen contraction showed a significant difference in contraction activation in samples treated with the 2% colostrum derivative mixture compared to the control. The analysis of the supernatant showed an inhibition of metalloproteinase-2 expression and an increase in collagen secretion by fibroblasts in treatment samples. Our hypothesis is that the molecules extracted and purified from bovine colostrum restore the ECM environment qualitative and quantitative characteristics, thus guaranteeing through a mechanical action the restoration of the wound due to the transduction of the signal activated by the integrins.
Depicting of DNA Makeup of Spring Bread Wheat Genotypes Using SSR Markers and Their Association with Heat Tolerance
Authors: Amin Md. Forhad , Alam Mohammad Nur , Faruq Golam , Khan Md. Mustafa , Rahman Md. Mahbubur
Published: September 2024

Wheat is threatened by global warming. This study aimed to characterize based on DNA profile and identify heat-tolerant wheat genotypes. Fifteen wheat genotypes were sown in Nov 21 and Dec 21 and evaluated within 13 SSR markers. A dendrogram classified the genotypes into two main groups. The highest genetic distances (0.93) were drawn between BAW 1290 and BARI Gom 28, and the lowest one between Nadi 2 and BAW 1147. Heat susceptibility index (HSI) values for 1000-grain weight (TGW) and grain yield indicated moderate heat tolerance in Cluster I genotypes (HSI 0.50-1.00), closely matching Group A's Cluster II members. In Group B, Cluster III genotypes had higher HSI (1.04-1.23) and significant reductions in TGW and grain yield under heat stress, indicating heat susceptibility. The varieties BARI Gom 25, 26, 27, 28, 29, and 30 were identified as heat-stress tolerant. This research provides insights for future heat stress-molecular breeding programs.
Development and Validation of the Short form of the Joint Assessment of Equilibrium and Neuromotor Status Scale (JAEN-10)
Authors: Peinado-Rubia Ana Belén , Osuna-Pérez María Catalina , Núñez-Fuentes David , Rodríguez-Almagro Daniel , Zagalaz-Anula Noelia , Lomas-Vega Rafael
Published: September 2024

Objective: To develop and validate the short version of the JAEN Scale for use in women with Fibromyalgia Syndrome (FMS) to make the balance disorder measurement process more efficient. Methods: A Cross-sectional observational validation study was conducted. Fifty-six women with FMS and 44 healthy control were included. Certain items of the original tool were selected with the aim of 1) Improving internal consistency by reducing item redundancy 2) Obtaining a diagnostic capacity with an Area Under the ROC Curve (AUC) greater than 0.70 for discriminating FMS patients and fallers. The internal consistency, factorial validity, concurrent validity and diagnostic capacity of the new tool were analyzed. Results: Factorial analysis showed a two-factor structure that explained 72% of variance. Cronbach alpha coefficients of 0.904 were obtained for the total score of the JAEN-10 items. Concurrent validity analysis showed strong correlations of the JAEN-10 with other instruments that measured quality of life, postural balance or disability related to dizziness. The score of the JAEN-10 items showed an AUC of 0.858 with a sensitivity of 64.29 and a specificity of 95.45 for discriminating between FMS and healthy controls, and an AUC of 0.835 with a sensitivity of 90.48 and a specificity of 67.24 for discriminating between fallers and non-fallers.; Conclusions: The 10-item JAEN scale is a valid instrument for discriminating between subjects with or without FMS and between fallers and non-fallers. Its psychometric properties are good and similar to those of the original 20-item scale. Moreover, it is quicker to complete, which may be relevant in subjects with a tendency to experience fatigue.
ESG into Supply Chain Management in SMEs: Effect Factors and Implementation Path
Authors: Yue GUO , Tailai GUO , Guo Huabo , Yongxin ZHANG
Published: September 2024

With the increased global attention to environmental protection, social responsibility and corporate governance (ESG) standards, integrating ESG into supply chain management (SCM) is becoming a strategic requirement for companies to achieve competitiveness and sustainable development. This study reviews the impact factors of ESG practices on supply chain competitiveness, and empirically examines the mechanism of ESG performance on supply chains through a questionnaire survey with a sample of Chinese SMEs. It was found that normative pressure, coercive pressure and imitative pressure in SMEs have a significant positive effect on cognition and attitude and perceived behavioral control; good corporate cognition and attitude, perceived behavioral control and corporate pressure also enhance the level of ESG practices. Further analysis shows that cognition and attitude and perceived behavioral control play a mediating role in the impact of ESG practices, and ESG performance promotes sustainable development of SMEs. The article puts forward the following suggestions: (1) close supply chain partnerships to enhance green innovation; (2) the government should give more resource support to ESG-invested enterprises and support the development of advantageous enterprises; (3) improve the corporate disclosure mechanism and strengthen the supervision; and (4) strengthen the training of professionals in supply chain ESG management.
Identifying Key Factors in Papilla Growth Around Implants: Focus on Intraoral Negative Pressure
Authors: Daniele Botticelli , Agabiti Ivo , Yamada Rihito , Maniwa Nozomi , Apaza Alccayhuaman Karol Alí , Nakajima Yasushi
Published: September 2024

Background: The absence of interdental papillae in dental prosthetics often results in unsatisfactory esthetic outcomes, such as black triangles and elongated clinical crowns. Although previous research has shown that gingival papillae can regenerate in a coronal direction, the mechanisms behind this phenomenon are not fully understood. Various theories have been proposed as potential explanations. Materials and Methods: This study evaluated several factors potentially influencing papilla growth, including adjacent elements, buc-cal-lingual papilla width, contact point position, convergent neck, crown overcontour, and intraoral negative pressure. A conceptual map was created to organize these factors, followed by their classification using a modified Overton Window. The principle of parsimony (Occam's Razor) was applied to identify the most plausible cause-related factors, categorizing them as causal relationship factors, filtered out factors, essential factors, or influencing factors. A mind map was used for visual grouping. Results: The analysis identified intraoral negative pressure as the most plausible cause-related factor for spontaneous papilla growth. Factors such as inflammation and drug-induced hyperplasia were excluded due to their association with unhealthy tissue. Other factors were classified as essential or influencing, but without direct causal links to papilla growth. Conclusions: Intraoral negative pressure is likely a key contributor to spontaneous papilla growth around implants. This finding, supported by abductive reasoning and the exclusion of less plausible factors, offers a new direction for enhancing esthetic outcomes in dental prosthetics, though further research is needed to confirm this causal relationship.
Performance Evaluation of Hydrological Models Using GR4J Rainfall-Runoff Model for Developed Watersheds in Java Island
Authors: Munajat Cecep Muhtaj , Darsono Sri Legowo W. , Harlan Dhemi
Published: September 2024

Abstract: GR4J (Genie Rural a 4 parame`tres Journalier) is a rainfall-runoff model widely used to modelling rainfall into discharge. In this model, the input data used are daily rainfall and evapotranspiration data, calibrated using daily observed discharge data. This model seeks the optimum parameter value that produces the minimum deviation or error. The Nash-Sutcliffe Coefficient and Relative Volume Error (RVE) are used to estimate the errors that occur. One of the modelling parameters, namely X4 (peak time), has a value that does not match the observed hydrograph peak time (Tp). For this reason, it is necessary to adjust the modelling equation so that the unit hydrograph of the model appropriately in terms of value and shape with observed unit hydrograph. This study examines ten watersheds in Java Island so that it is expected to represent catchment conditions in tropical areas and developing countries. A relationship was obtained between the difference peak time from modelling (X4) and observed Tp. Adjustments Formula can be made to the general GR4J modelling equation for unit hydrograph in Java Island watersheds.
Gemcitabine Delivery System Based on Chitosan Capsules with Magnetite and Natural Zeolite (Clinoptilolite). Synthesis, Characterization and Evaluation of Its Anticancer and Bactericidal Properties
Authors: Guarín-González Yuly Andrea , Cabello-Guzman Gerardo , Reyes-Gasga José , Moreno-Navarro Yanko , Vergara-González Luis , Martin-Martín Antonia , López-Muñoz Rodrigo , Cárdenas-Triviño Galo , Barraza Luis Felipe
Published: September 2024

Cancer and infectious diseases are two of the world's major public health problems. Gemcitabine (GEM) is an effective chemotherapeutic agent against several types of cancer. In this study, we developed macrocapsules by incorporating GEM into a chitosan matrix blended with magnetite and zeolite. The physico-chemical characterization of the precursor materials and the new delivery system was carried out by HRTEM-ED, XRD, FESEM-EDS, FT-IR, TGA, encapsulation efficiency (%E.E.) and release profiles at pH 7.4 and 5.0. Cell viability tests on A549 and H1299 cell lines and microbiological properties against staphylococcal strains were performed. Our results revealed the successful production of hemispherical capsules with an average diameter of 1.22 mm, a rough surface and characteristic FT-IR material interaction bands. GEM encapsulation rates exceeded 80%, and release profiles were well-controlled over 24 hours at tested pH levels. Notably, cell viability in H1299 cells was lower than the free GEM control. Moreover, the formulation exhibited potent antimicrobial activity against Staphylococcus epidermidis, highlighting its dual action as a chemotherapeutic and antimicrobial agent. This dual effect underscores the potential of these macrocapsules as innovative delivery system for treating lung cancer in patients who are also at risk of infectious diseases and who are immunosuppressed.
The Extended Mind & Body in Extended Realities: A Scoping Review of XR Applications and Risks in the Metaverse
Authors: Kourtesis Panagiotis
Published: September 2024

This scoping review explores the intersection of Extended Mind Theory and Extended Reality (XR) technologies, focusing on how Virtual Reality, Augmented Reality, and Mixed Reality reshape human cognition and interaction. XR enables users to offload cognitive tasks and engage in embodied experiences, extending cognition beyond the brain into digital environments. The review highlights a wide range of XR applications, from immersive learning in STEM education and medical training, neuropsychological assessment to therapeutic interventions, arts and entertainment, professional skills development, retail and e-commerce, remote work, sports training, architecture and urban planning, and cultural heritage preservation. XR's integration with modalities like haptics, eye-tracking, face- and body-tracking, and brain-computer interfaces further enhances cognitive extension and user engagement. However, alongside these advancements come significant ethical, psychological, and societal challenges, such as data privacy concerns, the psychological effects of prolonged immersion, and social inequality arising from disparate access to XR technologies. This review emphasizes the need for robust ethical frameworks that address these challenges, ensuring that XR technologies enhance human development while maintaining autonomy, privacy, and mental well-being. As XR continues to evolve and integrate with artificial intelligence and other emerging technologies, its role in expanding human cognition will depend on responsible implementation and governance.
Recent Updates of PET in Lymphoma: FDG and Beyond
Authors: Kim Sung-Yong , Chung Hyun Woo , So Young , Lee Mark Hong , Lee Eun Jeong
Published: September 2024

Lymphoma is one of the most common cancers worldwide, categorized into Hodgkin lymphoma and non-Hodgkin lymphoma. 18F-fluorodeoxyglucose positron emission tomography (FDG PET) has become an essential imaging tool for evaluating patients with lymphoma in terms of initial diagnosis, staging, prognostication, and treatment response assessment. Recent advancements in imaging technology and methodologies, along with the development of artificial intelligence, have revolutionized the evaluation of complex imaging data, enhancing the diagnostic and predictive power of PET in lymphoma. However, FDG is not cancer-specific, but it primarily reflects glucose metabolism, which has prompted the investigation of alternative PET tracers to address this limitation. Novel PET radiotracers, such as fibroblast activation protein inhibitors targeting the tumor microenvironment, have recently shown promising results in evaluating various malignancies compared to FDG PET. Furthermore, with the rapid advancements in immunotherapy and the favorable imaging properties of 89Zr, immunoPET has emerged as a promising modality, offering insights into the functional and molecular status of the immune system. ImmunoPET can also facilitate the development of new antibody therapeutics and radioimmunotherapy by providing pharmacokinetic and pharmacodynamic data. This review provides comprehensive insights into the current clinical applications of FDG PET in lymphoma, while also exploring novel PET imaging radiotracers beyond FDG, discussing their mechanisms of action and potential impact on patient management.