bluuebunny/crossref_metadata_2025 huggingface dataset:
Življena nemogućnost
Authors: Prole Dragan
Published: February 2025

Članak ispituje fenomenološki pojam početka na temelju autorove teze da transformacija povijesti filozofije u drugoj polovici devetnaestog stoljeća podrazumijeva uvođenje osobnih, egzistencijalnih ili životnih motiva. Otuda povijest filozofije prestaje važiti kao jedna i jedinstvena, već postaje mnoštvena i heterogena. Edmund Husserl tako prepoznaje tri fundamentalna toka. Najprije povijest neuspješnih pokušaja filozofije da ostvari svoj telos. Na drugom je mjestu povijest konstitucije prirodnih znanosti u znaku trijumfa lažne umnosti. Napokon, fenomenologija sebe vidi kao filozofiju početka, obećanje ostvarenja onoga što su filozofi oduvijek htjeli. Korijene Europe Husserl vidi u filozofiji, ali s filozofijom u pravom smislu riječi nije se započelo. Otuda je i europska filozofija nužno sablast, tvorevina koja je propustila vlastiti početak. Po Husserlu, propust filozofske Europe ne sastoji se u greškama i zabludama koje se uvijek iznova vraćaju. On se sadrži u tome što autentična europska filozofija ne može započeti na pravi, istinski, autentičan način. Njezini su počeci lažni, samo su simulacija započinjanja. Husserlova sablast pojavljuje se tako što se odbija pojaviti.
Rainfall prediction using artificial neural networks and machine learning algorithms over the Coimbatore region
Authors: Kandasamy Oviya , N. Maragatham , E. Somasundaram , R. Ravikumar , Kannan Balaji , C. Pradipa
Published: February 2025

Due to ongoing climate change, accurately predicting rainfall has become increasingly critical. This paper explores an approach utilizing two different machine learning algorithms, including multilayer perceptron neural networks (MPNN) and random forest regressors (RFR), to enhance rainfall forecast accuracy. Historical daily weather data spanning 100 years (1913–2023) from the Agro Climate Research Centre at Tamil Nadu Agricultural University were used. The study focused on global climate drivers like the Southwest Monsoon (SWM) and Northeast Monsoon (NEM) over the Coimbatore region; this region receives more rainfall during NEM. Normalization and scaling techniques addressed missing values, preserving 70–85% of the original data for the training set. Results demonstrated that MPNN outperformed RFR, achieving an accuracy of 85.55% for SWM and NEM, while RFR outperformed MPNN, producing an accuracy of 86.50%. The coefficient of determination (R2) for predicted versus observed values was 0.8 for daily rainfall from 2020 to 2023.
Facilitators/barriers to the implementation of public policies and strategies towards water security, Lao PDR
Authors: Sychareun Vanphanom , Thongmixay Souksamone , Vongxay Viengnakhone , Somphet Vathsana , Phommavong Chandavieng , Phommavongsa Phouthong , Phanthamala Singthong , Khongsab Somphone , Detchanthachack Khamthavisouk , Thongmala Vilakone , Durham Jo
Published: February 2025

Lao PDR's growing economy, urbanization, and changing lifestyles are putting pressure on water resources, necessitating effective water management for economic growth and population well-being. This qualitative study aimed to explore the facilitators and barriers to the implementation of water-related policies in Savannakhet and Champassak provinces both of which are considered vulnerable to reduced water security. Eighty-seven key informants (KIs) have been interviewed about the awareness of water policies/strategies and the facilitators/barriers to the implementation of water policy. Overall, KIs working at the national and provincial levels had a better understanding of existing policies compared with participants from the district officials. According to KIs, facilitators of the implementation of water policies were dissemination of the legislation and policies related to water security to the relevant ministries, departments and agencies, publicizing their obligations under these policies, and increasing community awareness and participation. Identified barriers were lack of technical capacity, infrastructure, and budget and coordination. Overall, these barriers were reported to contribute to a weak and somewhat fragmented approach to water security. Further effort is required to improve inter-agency collaboration and better resource the water resource sector.
Pathways of major ion chemistry and evaluation of contaminants in the River Ajay, India
Authors: Kumar Balwant , Padhy Pratap Kumar , Kumari Deepa , Singh Mohan Prasad , Goswami Shreerup , Singh Umesh Kumar
Published: February 2025

Hydro-geochemical studies of water quality and identification of polluting agents present in the river system are important for the sustainable utilization of water resources. This study focuses on the evaluation and interpretation of major ion chemistry, hydro-geochemical processes, and the suitability of water quality in domestic and agricultural usage areas. The water quality parameters, total dissolved solids (TDS), electrical conductivity (EC) and NO3− have wide variations along the sampling sites. The river has Ca2+, Mg2+ and NO3− dominant ions. The chemistry of water is largely determined by rock weathering and ion exchange processes with low contribution from anthropogenic sources. The water of the Ajay River is not suitable for drinking and irrigation purposes due to high levels of TDS, EC, NO3−, biochemical oxygen demand (BOD), chemical oxygen demand (COD), total coliform (TC) and fecal coliform (FC). Principal component analysis (PCA) suggests that rock weathering, atmospheric deposition and anthropogenic activities together influence the water quality/chemistry. The Water Quality Index (WQI) indicated that 78% of water falls under medium, 15.7% under bad and only 5.2% of water falls under good category. Thus, this study illustrates the identification of pollution sources and interpretation of the complex data of the Ajay River that will be helpful for river water quality management for this river in particular and other river systems of the globe in general.
Innovative pre-treatments for reverse osmosis to reclaim water from biotech and municipal wastewater for the industrial symbiosis in Kalundborg
Authors: Jährig Jeannette , Kleyböcker Anne , Kraus Fabian , Melchiorsen Line Rodenkam , Milter Hasse , Thisgaard Preben , Vredenbregt Leo , Miehe Ulf
Published: February 2025

The challenge of water reclamation using membranes in this study was the quite unique wastewater composition resulting from a high share of biotech wastewater. The high content of organic matter and high concentrations of calcium, bicarbonate, and sulphate were considered as challenging for membrane processes. Consequently, an innovative ultra-tight ultrafiltration (u-t UF) membrane was developed and tested on-site at pilot scale. In comparison, a conventional UF and an open nanofiltration (NF) were piloted. The aim was to find the best pre-treatment option for reverse osmosis (RO) to reduce fouling and scaling and produce fit-for-purpose water; for example, cooling. Overall, the quality of the currently used water source was surpassed by the pilot plant. Only a standard post-treatment of the RO permeate was necessary for stabilisation. Results indicated that denser membranes only minimally reduced fouling of RO. An assessment comparing the treatment trains in a life cycle assessment using the data collected from the pilot operation (UF/NF operating settings, RO plant performance, and the design of multi-stage industrial scale RO) revealed lower greenhouse gas emissions compared to seawater desalination. However, if RO brine needs to be treated, greenhouse gas emissions for water supply via wastewater reuse exceed other freshwater source.
Ternary micro-electrolysis filter media for efficient PFOA removal in water: synthesis, characterization, and performance study
Authors: Li Shuilian , Zhang Lishan , Zhong Shan , Zhu Jiayan , Wei Zengxian
Published: February 2025

This study reports the preparation of granular ternary micro-electrolysis materials and their effectiveness in removing the emerging contaminant PFOA. Al/nZVI/C@F granules were synthesized using a liquid-phase reduction method combined with high-temperature calcination. By comparing the removal of methylene blue dye by granules, the optimum preparation conditions were determined as follows:Fe:C = 5:1, fly ash = 50%, calcination temperature = 800 °C, and holding time = 1 h. Static batch experiments revealed that under optimal conditions (PFOA concentration = 25 mg/L, solid–liquid ratio = 30 g/L, pH = 3, reaction temperature = 15 °C), Al/nZVI/C@F achieved a PFOA removal rate of 97.83%. The removal efficiency of Al/nZVI/C@F (93.90%) was significantly higher than that of commercial iron-carbon (12.75%). After 45 days of dynamic column experiments, the removal efficiency of nZVI/C@F and Al/nZVI/C@F for PFOA (50 mg/L) remained above 60%, demonstrating strong practical application potential. Further adsorption–desorption experiments revealed that nZVI/C@F and Al/nZVI/C@F primarily removed 50 mg/L PFOA through adsorption. For a lower PFOA concentration of 0.5 mg/L, the defluorination rates were 53.2% for nZVI/C@F and 68.9% for Al/nZVI/C@F. High-performance liquid chromatography-tandem mass spectrometry was used to analyze the intermediates formed during PFOA removal, leading to a proposed degradation pathway.
Synthetic Strategies to Substituted Chiral Furans: A Review
Authors: Mal Kanchan
Published: February 2025

Themultifunctionalizedchiralfuran derivatives are importantbuilding blocks as many natural products
and bioactive compounds contain these scaffolds. The chiral furan derivatives also act as potent intermediates in
valuable synthetic transformations. Therefore, the development of facile methodologies for accessing the substituted
chiral furans from easily available precursors is a nintriguing topic in the field of organic chemistry. In
this review, several efficient strategies for the synthesis of substituted chiral furans have been discussed.
Amongst these, the functionalization of furan moieties, organocatalytic/enantioselective approaches, chemoenzymatic
kinetic resolution, and utilizations of carbohydrates as chiral pool precursors are of great importance.
Diverse Therapeutic Potentials of Hypericin: An In-Depth Review
Authors: Maurya Sandeep Kumar , Divakar Sheetal , Rathee Sunny , Patil Umesh Kumar
Published: February 2025

Background:

This review is delving into determining the content and significance of
hypericin, a pharmacologically important constituent commonly known as St. John's Wort (SJW).
The paper explores the rich history of Hypericin's traditional use in alternative medicine and the
recent surge in scientific interest surrounding its bioactive properties.

Objective:

This review aims to comprehensively analyse the therapeutic potentials of hypericin,
focusing on its chemistry, extraction, sources, stability, pharmacokinetics, safety profile, and multifunctional
applications in drug and medicinal fields as well as advancements in Bioengineering
Approaches for Enhanced Hypericin Delivery.

Methods:

We performed a non-systematic search of journals. Literature using computerized methods
was conducted, utilizing databases such as Medline (PubMed), ChemSciFinder, China National
Knowledge Infrastructure (CNKI) and Scirus Library. To effectively identify the most important
and relevant research articles, scientific studies, clinical studies and review articles on hypericin
were searched using different keywords: “Hypericum”, “traditional use”, “phytochemistry”,
“pharmacology”, “drug delivery” and “bioactivity”. Thus, articles available from 1984 to 2024
were analyzed and collected. The selection process for the review primarily considered the originality
of the paper and its clinical applications.

Results:

Although hypericin is not a novel compound within the research community, it is gaining
renewed recognition and showing great effectiveness as a promising agent in the field of medical
diagnostics and has promising applications as a therapeutic.

Conclusion:

Here, our current comprehensive review of hypericin, its potential and its activities is
intended to contribute to this ongoing process actively. Overall, this review provided theoretical
direction for future hypericin research. Future studies should, therefore, focus further on the pharmacological
processes, pharmacokinetics, and chemistry of hypericin and hypericin-based drug
delivery systems. Our most recent overview of hypericin's functions and potentials is meant to aid
in this process.
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives
Authors: Sharma Kiran
Published: February 2025

Artemisinin and its semisynthetic derivatives are a group of bioactive chemicals obtained
mostly from the extracts of Artemisia species that exert a significant amount of antimalarial
activity while remaining relatively safe and tolerable. However, their effectiveness is not limited to
malaria; it extends to a variety of human infectious diseases. Mostly the mode of action includes
the generation of free radicals by breaking the endoperoxide link in its molecular structure, which
facilitates the eradication of microbial species. Artemisinins are found to inhibit bacterial, viral,
protozoal, helminth, and fungal infections. Their derivatives, like artemisone, a reversible inhibitor,
target the viral replication cycle, and artesunate suppresses EBV infection by inhibiting the
production of early EBV proteins. They were also found to be highly effective against Helicobacter
pylori and Mycobacterium tuberculosis by generating peroxides in a time and concentrationdependent
way. Other derivatives, such as artesunate, artemether, and arteether, have also shown
antimicrobial activity that can be administered orally, rectally, intramuscularly, or intravenously.
This review aims to provide a complete update on the antimicrobial applications of Artemisinin
and its semi-synthetic derivatives, as well as derived dimers/trimers. The paper reflects a significant
potential for the discovery of novel Artemisinin medications that can be used as supplementary
treatments for various diseases. However, further translational and experimental research is
required for optimization and the establishment of pharmacokinetic profiles. In addition, health
authorities are also required to regulate the present Artemisinins and newly discovered derivatives
to ensure their long-term effectiveness in the worldwide fight against antibiotic resistance.
Ethnopharmacological Insights on Plumeria obtusa L.: A Comprehensive Review of its Phytochemistry and Pharmacological Properties
Authors: Salar Sapna , Singh Mhaveer , Yadav Dinesh Kumar , Kumar Vijay , Ekbbal Rustam , Kumar Santosh
Published: February 2025

This extensive review paper explores the ethnopharmacological viewpoints of Plumeria
obtusa L., commonly referred to as "Frangipani," clarifying its complex phytochemistry and
range of pharmacological characteristics. Plumeria obtusa has a long history of ethnobotanical
uses and is widely used in traditional medicinal practices across many countries. Through a methodical
investigation of its phytochemical components, the review reveals a diverse range of bioactive
substances, such as phenolic compounds, alkaloids, flavonoids, and terpenoids. The plant's
potential for medicinal use is greatly enhanced by these ingredients. There is a thorough discussion
of Plumeria obtusa’s pharmacological characteristics, including its anti-inflammatory, antibacterial,
antioxidant, and anticancer effects. Using information obtained from both current and
historic studies, the article offers a comprehensive overview of the plant's many therapeutic uses.
It also provides insights into the significance of using scientific research to validate traditional
applications, opening the door for Plumeria obtusa incorporation into contemporary healthcare
procedures. This paper focuses on Plumeria obtusa ethnomedical usage, describing its traditional
use in the treatment of a range of ailments. The study points out information gaps and recommends
future studies to explore its therapeutic and multi-mechanistic approaches. It also suggests
possible directions for clinical investigations. To sum up, this study provides a comprehensive
overview of Plumeria obtusa L. by combining ethnopharmacological ideas, phytochemical data,
and pharmacological discoveries. This plant presents itself as a good option for new medicinal
uses when conventional wisdom and scientific investigation are combined.
Evanescent Field-based Sensor Design Using Uniform Strips on SOI-based Slot Type of Waveguide for Brain Cancer Application
Authors: Jha Prachi , Chandra G. Charan , Avinash T. Venkat , Chandra Veer
Published: February 2025

Introduction:

The slot type of photonic waveguide is commonly used in designing
sensors based on the evanescent field because of its high evanescent field characteristics.

Method:

In this study, we introduced multiple uniform strips to improve the performance of the
waveguide, aiming for a higher evanescent field ratio and reduced propagation loss to optimize the
effectiveness of the sensor. The inclusion of uniform strips enhances the overall capabilities of the
waveguide for evanescent field-based sensing applications.

objective:

This study aims to improve the evanescent field and sensitivity of slot waveguide structures while keeping propagation loss minimal. The research explores the potential applications of different slot waveguide configurations, particularly for sensors like the brain cancer sensor.

Result:

The investigation showed that the one-strip and three-strip design structures achieved
maximum evanescent field values of 0.43 and 0.38, respectively, indicating significant levels.
However, the three-strip design structure exhibited the minimum propagation loss, recorded at 9.1
dB/cm. Considering the variations in Evanescent Field Ratio (EFR) and propagation loss, the slot
waveguide with three strips emerges as a potentially optimal design structure.

Conclusion:

This conclusion is particularly relevant in the context of brain cancer applications,
where heightened sensitivity is crucial. Therefore, the three-strip configuration shows promise for
superior performance in detecting and addressing the complexities of brain cancer.
An LC-MS/MS Approach for the Identification of Degradation Products of Serdexmethylphenidate and Dexmethylphenidate and Elucidation of their Degradation Pathway
Authors: Gollu Gowri , Gummadi Sowjanya , Sahoo Santosh Kumar , Panda Jagadeesh
Published: February 2025

Background/Objective:

A combination of serdexmethylphenidate and dexme-thylphenidate is used to treat attention deficiency hyperactivity disorder. A stability-indicating RP-HPLC method has been developed and reported in the literature. As there is no study on the degradation product identification, in this work, the degradation behavior of serdexmethylpheni-date and dexmethylphenidate was explored by subjecting combined dosage to the forced degrada-tion study by applying the developed RP-HPLC method. Further, plausible structures and frag-mentation patterns of all the degradation products were identified by the LC-MS/MS study.

Methods:

The forced degradation study was conducted by exposing the combined dosage form (Azstarys) as per International Council of Harmonization (ICH) guideline Q1A (R2). Using LC-MS/MS, MS spectra were obtained. Based on the m/z values and molecular formula, probable structures of degradation products were elucidated.

Results:

A total of 7 degradation products were detected, of which, 4 degradation products were formed from serdexmethylphenidate. The remaining 3 degradation products were formed from dexmethylphenidate. The possible structures and fragmentation patterns of all the degradation products were examined with the help of the LC-MS/MS study.

Conclusion:

As possible structures and fragmentation patterns were identified by the LC-MS/MS study, this method may help in the development of quality dosage forms, maintaining proper stor-age conditions, and also in impurity profiling studies.
Desain Furnitur dengan Prinsip Keselamatan Siswa (Objek Penelitian: SDN Ketawanggede Kota Malang)
Authors:   Program Magister Arsitektur Lingkungan Binaan, Departemen Arsitektur, Fakultas Teknik, Universitas Brawijaya, Malang, Muhamad Infaroyya Al Karimah , Sufianto Heru ,   Departemen Arsitektur, Universitas Brawijaya, Malang, Titisari Ema Yunita ,   Departemen Arsitektur, Universitas Brawijaya, Malang
Published: February 2025

In Indonesia, the prevalence of injuries in school-age children is quite high, with around 6.5% of incidents occurring in the school environment. According to WHO (2022), fall injuries are one of the leading causes of death globally, highlighting the importance of injury risk management, especially in primary school-aged children (6–12 years). Children in this age range have cognitive limitations in recognizing dangerous situations, so a safe physical environment at school is essential to support their safety and learning process. This study evaluates the safety of classroom infrastructure at SDN Ketawanggede, Malang. This study uses a descriptive-evaluative qualitative approach and case study methods to identify risk areas. The results of the study showed that the circulation of classrooms, furniture, and other design elements needed improvement. Recommendations include rearranging furniture and installing whiteboards according to ergonomic standards to improve safety and comfort in the learning process.
Comparison of Muscle Damage Markers and Myokines between Adult and Middle-Aged Marathon Runners
Authors: de Sousa Cesar Augustus Zocoler , Sierra Ana Paula Renno , Lima Giscard Humberto Oliveira , Martínez Galán Bryan Steve , Barbeiro Hermes Vieira , de Souza Heraldo Possolo , Cury-Boaventura Maria Fernanda
Published: February 2025

This study compared markers of muscle damage and myokines between adult and middle-aged runners before and after the marathon. Seventy-four male runners: 48 adults aged 30-44 years (AA group), and 26 middle-aged individuals aged 45-59 years (MA group) participated of the study. Blood samples were collected 24 hours before, immediately after, 24 hours and 72 hours after the marathon to measure skeletal and cardiac muscle damage markers (CK, LDH, troponin, and proBNP) and myokines (IL-6, IL-15, decorin, BDNF, GDF-15, FGF-21, apelin, musclin, myostatin, and follistatin). Before the marathon, it was observed that serum concentrations of BDNF were higher, and those of IL-15, GDF-15, apelin, and musclin were lower in the MA group. Immediately after the marathon, both groups showed higher activity of CK and LDH, as well as higher serum concentrations of ProBNP, troponin, IL-6, decorin, FGF-21, BDNF, and GDF-15. After the marathon and in the recovery period, GDF-15 concentrations remained lower and BDNF concentrations higher in the MA group compared to the AA group. In both groups, long-distance running induced muscle and cardiac damage and modulated myokines responsible for skeletal and cardiac muscle repair/adaptation. Middle-aged individuals show a reduction in the serum concentration of myokines that may contribute to muscle and cardiometabolic dysfunction in senescence. The role of higher levels of BDNF in middle-aged runners on cardiometabolic adaptation should be investigated to elucidate the molecular mechanisms of senescence.
The Utilization of Electronic Consultations (eConsults) to Address Emerging Questions Related to Long COVID-19 in Ontario, Canada: Mixed Methods Analysis
Authors: Singh Jatinderpreet , Quon Michael , Goulet Danica , Keely Erin , Liddy Clare
Published: February 2025

Background

Long COVID is an often debilitating condition affecting millions of people. Its diverse clinical presentations make effective diagnosis and management at the primary care level difficult, while specialist services for long COVID face extensive wait times. An electronic consultation (eConsult) program in Ontario developed a long COVID specialist group to allow primary care providers (PCPs) prompt access to specialist advice for patients with long COVID.

Objective

This study aims to assess patterns of service use, response times, impact, and clinical content of eConsult cases submitted to an eConsult long COVID specialist group in Ontario.

Methods

This study is a mixed methods analysis of eConsults submitted by PCPs to the long COVID specialist group of 2 eConsult services (Champlain eConsult BASE and Ontario eConsult) between June 1, 2021, and July 31, 2022. Data sources included the use data collected automatically by the services, responses to a mandatory closeout survey, and the content of PCP questions and specialist responses (Champlain eConsult BASE service only). Clinical questions or responses were analyzed using 2 validated taxonomies. Descriptive statistics were used for survey responses and use data.

Results

A total of 40 PCPs submitted 47 eConsults through Champlain eConsult BASE and 197 PCPs submitted 228 cases through Ontario eConsult. The median specialist response time was 0.6 (IQR 0.19-2.36; mean 1.7, SD 2.29) days. The 5 most common symptoms of long COVID were fatigue (14/47, 30%), dyspnea (7/47, 15%), cough (6/47, 13%), altered sense of smell (ie, anosmia and parosmia; 6/47, 13%), and cognitive changes (6/47, 13%). The five main question categories asked by PCPs were: (1) management of chronic symptoms of COVID-19, (2) need for additional work-up or follow-up testing, (3) community resources to support or manage patients with long COVID, (4) diagnostic clarification, and (5) guidance regarding COVID-19 vaccination.

Conclusions

The long COVID groups provided rapid access to a multispecialty service that facilitated the avoidance of unnecessary face-to-face referrals. An assessment of eConsults highlighted 5 common question types, providing insight into potential gaps in knowledge among PCPs that could help guide medical education and policy.
Development and Implementation of Strong Foundations, a Digitally Delivered Fall Prevention Program: Usability and Feasibility Pilot Exercise Cohort Study
Authors: Moran Ryan , Wing David , Davey Hope , Barkai Hava , Nichols Jeanne
Published: February 2025

Background

Falls remain a major public health problem and a significant cause of preventable injury. Maintaining strength and balance by staying active can prevent falls in older adults, and public health advocates support referral to community exercise programs. Given the growth in use and acceptance of technological interfaces, there remains an interest in understanding the role of a synchronous exercise program designed to improve strength, postural alignment, and balance specifically designed to be delivered in a digital environment with respect to usability and feasibility.

Objective

This study aims to design and implement a synchronously delivered digital fall prevention program to adults aged 60 years and older, to understand the usability, feasibility, and attendance.

Methods

The “Strong Foundations” program, a 12-week, live, digitally delivered fall-prevention exercise program was informed from different existing in-person exercises and piloted to older adults who were considered a low fall risk by scores of 4 or less from the Centers for Disease Control and Prevention’s (CDC’s) Stopping Elderly Accidents and Deaths Initiative (STEADI) Staying Independent questionnaire. The System Usability Scale (SUS) measured usability and feasibility at the completion of this program, and digital measures of age-related function (timed up and go [TUG] and 30-second chair stand [30 CS]) were collected pre- and postintervention. Data were collected in 2021.

Results

A total of 39 older adults were recruited and 38 completed the 12-week program with an average age of 72 years. The average SUS was 80.6, with an 85% attendance rate and an 8.5 (out of 10) self-reported satisfaction score. Digitally collected TUG and 30 CS statistically improved pre- and postintervention by 9% and 24%, respectively; by week 12, 64% (23/36) of participants improved in the timed up and go and 91% (32/35) improved the chair stands.

Conclusion

There was excellent usability and acceptability for Strong Foundations, a novel fall-prevention program designed to be delivered digitally and promising improvement of objective measures of fall risk.
Integrating a Combination HIV Prevention Intervention into a Widely Used Geosocial App for Chinese MSM: Pilot Study Protocol and Baseline Data (Preprint)
Authors: Huang Wenting , Ning Kunru , Koh Ernest Shi Hao , Mi Guodong , Yu Fei , Liu Yufen , Stegmueller Daniel , Powers Kimberly A. , Baral Stefan , Sullivan Patrick S. , Siegler Aaron J.
Published: February 2025

BACKGROUND

HIV disproportionately affects men who have sex with men (MSM) in China, but the use of HIV prevention services is low due to privacy concerns and nondisclosure of sexual identity. These concerns are addressable through home-based services.

OBJECTIVE

This study aimed to assess feasibility and acceptability of Blued+, a combination HIV prevention intervention that integrated combination package of HIV prevention services into the Blued mobile application platform, for Chinese MSM.

METHODS

This study was a single-arm pilot study with a repeated cross-sectional design as a comparison. A cohort of MSM was recruited from Beijing and Chengdu, China. A three-month standard-of-care period with measurement at enrollment and month 0 (baseline) was followed by a 12-month intervention period with measurement at months 3, 6, 9, and 12. Standard of care included the existing Blued app and local health services. During the intervention period, participants received the enhanced version of the Blued app with HIV testing, linkage to care for those testing HIV positive, free condoms and lubricants, in-app screening and provision to PrEP. A series of cross-sectional surveys at months 0, 6, and 12 were administered to MSM residing in Beijing and Chengdu who were not in any HIV prevention study. The primary outcome was the uptake of home HIV testing, condom, and PrEP prescription. The intervention acceptability was measured by the score of the system usability scale.

RESULTS

This study enrolled 423 participants in the pilot cohort and 1314 participants for cross-section comparison at baseline. Participants in the cohort were young. More than two-thirds obtained a college degree or above. More than a third of them were at a high level of income. Participants reported a high prevalence of condomless sex (63%) and HIV testing (71%) in the last three months. Most participants (96%) had heard of PrEP, and over a quarter had used PrEP. Participants in the comparison had comparable sociodemographic characteristics, but reported a lower proportion of people who had condomless sex (41%) and HIV testing (58%) in the last three months, and lower PrEP awareness (85%) and PrEP use (21%).

CONCLUSIONS

This pilot study will provide preliminary evidence for an efficacy trial of HIV prevention intervention that is integrated in an existing geosocial networking app among Chinese MSM by evaluating the feasibility and acceptability of this intervention.

CLINICALTRIAL

This is not a clinical trial.
The effectiveness of m-learning in knowledge retention of nurses' lifelong learning: quasi-experimental study (Preprint)
Authors: Cunha Sr Daniel José , Machado Paulo , Padilha José Miguel
Published: February 2025

BACKGROUND

The current Information and Communication Technologies, digital literacy, and ease of access to communication and information devices by nurses provide them with new ways and intention to access information for technical-scientific updating, ensuring the quality and safety of health care. M-learning offers a flexible and accessible alternative for continuing professional education, overcoming barriers such as time constraints and financial burden.

OBJECTIVE

To evaluate the effectiveness of m-learning in nurses’ knowledge retention of Chronic Obstructive Pulmonary Disease self-management, using a Massive Open Online Course with integrated virtual clinical simulation.

METHODS

A quasi-experimental pre- and post-test study was conducted, with no control group, with 168 nurses from a Portuguese hospital. The intervention included an asynchronous online course with 13 modules. Knowledge retention was assessed by comparing the mean scores before and after the course.

RESULTS

The results indicated a significant increase in knowledge retention. The participants' average score increased from 59.97% in the initial assessment to 84.05% in the final assessment (p<.001). Nurses with a master's degree exhibited a higher level of basic knowledge than those with a bachelor's degree. The course completion rate was 93.45%, reflecting significant engagement facilitated by gamification elements and the content’s clinical relevance.

CONCLUSIONS

M-learning is useful in nurses' lifelong learning, offering flexibility and more effective support for clinical practice. Integrating virtual simulation and gamification boosted motivation and reduced drop-out rates, highlighting the potential of m-learning in lifelong learning in healthcare. This study confirms the effectiveness of m-learning in improving knowledge retention in nursing. This strategy is a valuable approach to lifelong learning, promoting quality and safety in delivering healthcare.
Constructing Cultural Identity through International Collaboration in Ethnic Music Education within Multicultural Contexts
Authors: Sun Jian , Han Jiangtao
Published: February 2025

In the context of globalization, cultural identity has become a crucial aspect of education, especially in ethnic music education, which functions as a medium for transmitting cultural heritage. Ethnic music education focuses on traditional music forms specific to cultural groups and plays an essential role in shaping and expressing cultural identities. In multicultural settings, where various cultural groups coexist, ethnic music education serves as an important tool for preserving cultural traditions and fostering intercultural dialogue and mutual respect. A significant trend in ethnic music education today is international collaboration, which enables educators and students to explore diverse musical traditions. This exchange not only enriches musical knowledge but also helps individuals understand the construction and representation of cultural identities through music. However, while international collaboration has great potential, its effectiveness in shaping cultural identity remains complex. It can enhance the understanding of one’s cultural heritage and foster appreciation for other cultures. At the same time, it may create tensions when traditional practices confront globalized or Westernized ideals.
An Analysis of the Aestheticization of Daily Life through Korean Dramas
Authors: Zhang Chenjing
Published: February 2025

In the current society with rapid economic development, the aestheticization of daily life is playing an increasingly prominent role. The popularity of Korean dramas in recent years is one manifestation of the aestheticization of daily life. Aspects such as the plot, characters, and the love portrayed in Korean dramas have caused a strong response among audiences, bringing higher aesthetic demands and psychological satisfaction. Some details often overlooked by audiences in daily life are artistically expressed in Korean dramas, enabling audiences to discover the “truth, goodness, and beauty” in life, prompting them to seek and cherish the present real life.
A Study on the Current Learning Situation and Enhancement Strategies of Web Design Courses
Authors: Kang Wenqing
Published: February 2025

With the rapid development of the Internet, the importance of webpage design as an important carrier of information transmission is becoming more and more prominent. However, the current teaching status of web design courses in colleges and universities has many problems, such as lagging teaching content, single teaching method, insufficient practical ability of students, etc. These problems seriously restrict the quality of cultivating web design talents. The purpose of this paper is to analyze the current learning status of web design courses and discuss the enhancement strategies in order to provide reference for improving the teaching quality of web design courses.
VAT Compliance and Implementation in Trading Sector of Bangladesh: A Case Study
Authors: Biswas Md. Tanjil , Jahan Sayma , Akhkhar Nahian Tasfee , Islam Md. Mohianal , Islam Muhammad Tajul , Hasan S Q Ariful
Published: February 2025

Value-Added Tax (VAT) is a key revenue source for Bangladesh, yet its implementation at the trading stage remains underutilized due to low compliance, administrative challenges, and inadequate enforcement. Despite over 2.5 million wholesale and retail trade establishments, VAT registration among traders is only 2.8%, contributing a mere 1.5% of total VAT revenue. This study examines the challenges, compliance gaps, and enforcement issues affecting trade VAT in Bangladesh. The findings highlight complex registration processes, lack of awareness, informal business structures, and limited digital integration as major barriers. While initiatives such as Electronic Fiscal Devices (EFDs) and online VAT filing systems have been introduced, their adoption remains slow. The study recommends simplified VAT models for small traders, expanded digital infrastructure, stronger enforcement mechanisms, and targeted awareness programs to enhance compliance. Strengthening VAT at the trading stage can significantly increase revenue collection, improve tax transparency, and support economic growth.
Accuracy and Execution Time in Fake News Detection: A Comparative Analysis of Logistic Regression and Naïve Bayes
Authors: Mallavarapu Ritwik
Published: February 2025

The emergence of online misinformation has produced fake news detection as a significant field of study. Machine
learning algorithms like Logistic Regression and Naïve Bayes are commonly used to detect fake news because they are efficient
and interpretable. This research compares the performance of the two algorithms in identifying fake news based on accuracy,
precision, recall, F1-score, and the time taken to execute. While precision is vital in classification, execution time becomes
important in real-time scenarios. The research compares the models with respect to handling large data sets and classifying news
articles successfully. Furthermore, the computational cost of each algorithm is compared to establish its usability for large-scale
applications. The results indicate fundamental trade-offs between speed and precision, stressing the importance of optimal
models in preventing misinformation. Future work may consider hybrid methods or deep learning methods to enhance rates of
detection while ensuring computational efficiency
Experiências do PRP no curso de Ciências Exatas
Authors: Friedrich Leidi Cecilia , Parisoto Mara Fernanda
Published: February 2025

Os capítulos deste livro respondem às necessidades do processo de ensino e aprendizagem encontrados nas escolas-parceiras. Além disso, os textos conseguem nos mostrar a constituição da identidade profissional docente dos bolsistas, que analisaram, adequaram e reorganizaram o material didático e as estratégias didáticas de sala de aula, buscando outros formatos para a práxis a partir de reflexões teórico-práticas realizadas com os colegas, com os professores preceptores e com as professoras orientadoras
THE ANALYSIS OF STUDENTS’ DIFFICULTIES IN PRONOUNCING ENGLISH AFFRICATIVE CONSONANTS AT THE ENGLISH EDUCATION PROGRAM OF UNIVERSITAS JAMBI
Authors: A'yuni Indah Qurrata , Volya Duty
Published: February 2025

This research analyzes the difficulties in pronouncing affricative consonants for the English Education department of Universitas Jambi students. This study uses a mixed method, which uses qualitative and quantitative methods to collect the data. The sample of this research was 10 students registered in 2020 at the Universitas Jambi English Education Department. The researcher used a test and an interview as the instruments. This research results from 10 students; 2 of 10 were categorized as high ability, 4 of 10 were categorized as average ability, and 4 of 10 were categorized as low ability. The average score was 54,59, categorized as poor according to the percentage scale by Djumingin .S (2017:596). From the interview results, according to Antaris and Omulu (2019), factors are language origin, age, exposure, inherent phonetic capability, language and ego, and last, effort and commitment to proper pronunciation. The students found it difficult to pronounce English because English is not their first language or mother language. The student always uses their mother language rather than English in daily communication. Therefore, the results of this study with the low average score of the students were caused by English not being their first language and the rare use of English in daily conversations.
TEACHERS’ STRATEGIES IN ENHANCING` STUDENTS’ INTEREST IN READING USING DIGITAL MEDIA IN SMA ADHYAKSA 1 JAMBI
Authors: Rafid Kevin Khosiyi , Heryanti Reni , Fortunasari Fortunasari
Published: February 2025

Based on the results of the 2021 National Assessment (NA), show that Indonesia is experiencing a literacy emergency. This is because 1 out of  2 students has not reached the minimum literacy competency. This research aimed to explore the challenges or barriers faced by teachers in increasing students' reading interest using digital media and to explore their strategies to overcome the barriers. The participant of this research is an English teacher from SMA Adhyaksa 1 Jambi, which was selected based on several criteria. In this research, a descriptive qualitative method was applied, in which the researcher attempts to draw in as much detail as possible the data and facts collected in the field. A semi-structured interview was conducted to collect the main data, and documentation in the form of photos when observing the research location was carried out to support the data. Furthermore, the data were analyzed using an interactive analysis model. The findings revealed that barriers faced by the teacher in integrating digital media into teaching include constraints in supporting facilities and adapting to student's understanding of using digital media. Meanwhile, there are three strategies employed by the teacher, namely making preparations before the start of learning, providing material relevant to daily life, and using relevant digital media to enhance students' reading interest. Overall, this research shows several barriers faced by teachers in integrating digital media with learning to increase students' reading interest and highlights the strategies implemented by teachers to overcome these problems. Thus, it is suggested for future researchers who are interested in this field to find research gaps and use this research as a reference or comparison.
Influence of Adipose-Derived Stem Cell-Enhanced Acellular Dermal Matrix on Capsule Formation in Rat Models
Authors: Kang Hyun Su , Kang Myeong Jae , Hong Hyun Ki , Ryu Jeong Yeop , Lee Joon Seok , Choi Kang Young , Chung Ho Yun , Park Ho Yong , Yang Jung Dug
Published: February 2025

Background: The use of acellular dermal matrix (ADM) in breast reconstruction can inhibit capsular contracture, increasing the success rate of surgery. Adipose-derived stem cells (ADSCs) can effectively suppress foreign body reaction, which is a major cause of capsular contracture. This study aimed to elucidate the synergistic effects of combining ADSCs with ADM on capsule formation, utilizing a rat model.Methods: The study utilized 12 rats, equally divided into two experimental groups. Group A received silicone implants covered with ADM, while Group B was implanted with silicone prostheses wrapped in ADM, pre-seeded with ADSCs. Capsule formation was assessed through visual examination, histological analysis, and reverse transcription-polymerase chain reaction (RT-PCR) at 4 and 8 weeks post-implantation.Results: At 4 weeks, the mean capsular thickness was 177.16 μm in Group A and 170.76 μm in Group B; at 8 weeks, it was 196.69 μm in Group A and 176.10 μm in Group B. Statistical analysis showed no significant difference in capsule thickness between the groups (P>0.05). Histological findings indicated that Group A had more inflammatory cells and collagen fibers and reduced angiogenesis. RT-PCR showed that angiogenesis-promoting gene expression in Group B was 14% higher at 4 weeks and 156% higher at 8 weeks compared to Group A.Conclusion: Although no statistically significant reduction in capsule thickness was observed, ADSC-seeded implants showed histological features associated with reduced inflammation and enhanced angiogenesis, suggesting potential benefits in capsule formation management.
Invasive Marjolin’s Ulcer Penetrating the Scalp to Involve Bone and Dura Mater: A Case Report
Authors: Jung Jae-A
Published: February 2025

Marjolin’s ulcers are rare aggressive conditions that arise from chronic skin lesions and diseases. Various cell types may be observed in these lesions; however, squamous cell carcinoma is the most common type. Squamous cell carcinoma due to Marjolin’s ulcer has a greater tendency to metastasize than squamous cell carcinoma due to other causes. This condition occurs primarily on the lower extremities, although a few cases have been reported of it occurring on the scalp. Moreover, cases of penetration of bone and dura mater are observed even more rarely. In this article, we present a rare case of a Marjolin’s ulcer that penetrated the scalp and invaded the bone and dura mater.
State ownership, corporate missions and accountability of dividend policy: Empirical evidence of state-owned enterprises governance
Authors: Rossieta Hilda , Geraldina Ira , Mita Aria Farah
Published: February 2025

In the Indonesian context, state-owned enterprises (SOEs) are established to serve dual conflicting missions, namely: commercial and social-economy. This research hypothesized that the SOE mission’s focus (i.e., the single commercial mission versus the dual mission) affects SOE policy to pay dividends to the state as controlling owner. The sample is 52 SOEs covering the years 2009 to 2015, resulting in 364 firm-year observations which are grouped into the single commercial mission and the dual mission (Rossieta et al., 2019). The hypotheses are tested using unbalanced panel data and regression statistics. Consistent with the hypotheses, the results suggest that the association between net income and dividend level on the single commercial mission SOEs is stronger compared to the association on the dual mission SOEs. Empirical evidence also shows that the SOE’s mission type weakened the association. Presumably, the state as controlling owner perceived social-economy contribution as some form of return on investment, besides dividends as one source of the state revenue. For that reason, although the dual mission SOEs pay lower dividends relative to their income level compared to the single mission SOEs, yet, the payment is still considered accountable when referring to the Supreme Constitution and laws regarding the SOE’s mission.