bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of automation and monitoring methods for narrow-gap hot-wire laser welding using camera images
Authors: Marumoto K. , Sato Y. , Fujinaga A. , Takahashi T. , Yamamoto H. , Yamamoto M.
Published: October 2024

In this study, an image-based method was developed for hot-wire laser narrow gap welding. The welding process was monitored based on image information processed using semantic segmentation, a method of classifying images by pixel. To control the welding position, an experimental system was configured that automatically follows the welding position by recognizing the position of the welding groove from the image during welding. In monitoring weld defects, a method was developed to predict the lack of fusion occurring on the wall surface using brightness information near the wall surface. For the lack of fusion occurring at the bottom of the groove, a defect detection method was developed by monitoring the molten pool shape using semantic segmentation. Defects were generated by intentionally reducing the laser power, and the defects were monitored from images taken during processing. In the unstable state where the laser power was reduced, the shape in front of the molten pool became unstable, and the occurrence of defects was monitored by capturing the shape change. In conclusion, this research made it possible to control and monitor the welding process with a single camera.
Abstract Versus Concrete Risk Identification in Clinical Research in Japan: Randomized and Prospective Pilot Research on the Effect of Risk Reduction Activities in a Risk-Based Approach
Authors: Kondo Hidenobu , Chiu Shih-Wei , Hayashi Yukikazu , Takahashi Naoto , Yamaguchi Takuhiro
Published: October 2024

Background

The risk-based approach (RBA) of clinical trial was first introduced in 2011–2012. RBA necessitates implementing risk reduction activities that are proportionate to risk in order to reduce avoidable quality issues. However, there is no consistent methodology or research for identifying and evaluating risks and planning risk reduction activities. We aimed to evaluate risk reduction activities and their effects by using two risk identification and evaluation methods.

Methods

Among the risk identification and evaluation methods, we selected one method with the lowest number of categories for identifying risks [risk assessment form (RAF)] and one with the highest number [risk assessment tool (RAT)]. Each method was used to identify and evaluate risks in and plan risk reduction activities for the research on ponatinib blood concentration and treatment outcome in patients with chronic phase chronic myelogenous leukemia. RAF and RAT can identify risk using abstract questions and a list of concrete risks, respectively. The sites were randomized into two groups to implement planned risk reduction activities using RAF and RAT and to compare the mean of errors and protocol deviation per subject visit between the two groups.

Results

The mean of errors per subject visit and the mean of protocol deviation per subject visit were lower in the RAF group than in the RAT group.

Conclusions

Our study indicates that risk reductions can be successfully implemented by using a method to identify and evaluate risks in a small number of abstract categories that are critical to quality of clinical research.
Integrating Machine Learning for Enhanced Agricultural Productivity: A Focus on Bananas and Arecanut in the Context of India’s Economic Growth
Authors: Saruk B. S. , Rayalu G. Mokesh
Published: October 2024

Agriculture is one of the sectors that has an important impact, taking into account the problem of sufficient food supply on a global level. The process of predicting the yield of crops is among the most challenging undertakings in the agricultural industry. Agriculture is the main source of income for most developing nations. The purpose of the study is to investigate the significant role that agriculture plays in boosting India's economic growth. Additionally, the research considers the challenges posed by a growing population and a changing environment in terms of agricultural production and food security. The research focuses on analysing the complex characteristics of the agricultural industry, with a particular emphasis on the nutritional importance of tropical fruits, notably bananas and arecanut. These fruits are well-known for their vital nutrients and their role in ensuring world food security. This study acknowledges the importance of sustainable agriculture practices and incorporates sophisticated machine learning algorithms as dynamic tools to forecast crop yields and enhance decision-making processes throughout the crop development cycle. The main aim of this study is to create strong machine learning models and statistical techniques that can accurately predict crop yield by combining a variety of environmental parameters, then assess which models outperform each other. Assist yield projections may provide governments and policymakers with valuable information to make well-informed choices about food security, import–export policies, and resource allocation. It facilitates national- and regional-level food supply planning. The validation method utilises important metrics like R square (R2), Mean Absolute Error (MAE), and Root Mean Squared Error (RMSE). This present research adds to the continuing discussion on using creative methods to promote sustainable agricultural growth and ensure food security.
Learning to Live-with Climate Change through Film: The Arche-Cinema of Gummo as Climating and Becoming-Climate
Authors: Ferguson Joseph Paul
Published: October 2024

I am a cinematic being of the Anthropocene. As a concerned citizen and environmental educator, I immerse myself in film. Gummo is a 1997 film by Harmony Korine that deeply resonates with me as a testament to the capacity and desire for humanity to realise the potential to rise from the epochal fall of the Anthropocene. I propose that my relationship with Gummo as arche-cinema is not just a process of watching and interpreting Korine’s cinematic world, but also (re)projecting my dreams of a new reality for the whole-Earth ecosystem onto the world-out-there. I suggest that my entanglement with Gummo exemplifies my climating and becoming-climate as film in our current human-induced climate crises, and in this way, I argue that I am learning to live-with climate change through film.
Geometrical analysis of naturally grown timber for the design of load-bearing structures
Authors: Moreno Gata Kevin , Spahn Florian , Klinkel Sven , Trautz Martin
Published: October 2024

Combining tradition and innovation, timber plays essential roles in building structures for architecture and engineering. Tree branching geometries and timber in its natural state often serve as sources of inspiration. However, the mechanical properties of naturally grown timber, inherently inconsistent and geometrically varied, remain insufficiently studied, particularly for construction and simulations. This knowledge gap perpetuates the prevalent use of straight, uniformly harvested timber while neglecting curved and bifurcated elements with smaller cross-sections.

This research investigates the potential of naturally grown timber in structural design, emphasizing the importance of understanding the natural characteristics and growth patterns of trees to optimize timber use. The developed methodology leverages noninvasive technologies, such as computerized tomography (CT), to precisely capture the geometrical and material properties of wood. These data sources are then integrated to visualize cross-sectional geometries and material properties, forming the basis for our analytical approach. Utilizing generalized scaled boundary isogeometric analysis, the methodology enhances the accuracy and efficiency of simulations, aligning structural design with natural growth principles. This approach not only fosters sustainable resource practices by promoting the use of major tree parts but also transforms discarded materials into valuable resources. The paper concludes with a demonstration of this methodology applied in a practical construction scenario.
The Liberal Case for Community Land Trusts
Authors: Goëtzmann Marc
Published: October 2024

This paper argues that community land trusts (CLTs) can be part of a liberal housing policy from both an economic and a legal point of view. In this, I depart from the defense of community land trusts based on the so-called ‘decommodification’ of housing. First, from an economic point of view, CLTs are a comparatively better option than other traditional policies, such as rent control, once the political complexity of housing policies is considered. Second, fostering autonomy and the capacity for self-authorship requires that individuals be able to choose from a diverse set of valuable institutional designs; CLTs correspond to that ideal and bring a unique nuance to the existing options within common-interest communities. Additionally, I look at the somewhat recent legal innovations that brought CLTs to Canada and continental Europe to show that the institutional flexibility of CLTs allows them to support different visions of self-realization through ownership.
Predicting food insecurity in a pediatric population using the electronic health record
Authors: Rigdon Joseph , Montez Kimberly , Palakshappa Deepak , Brown Callie , Downs Stephen M. , Albertini Laurie W. , Taxter Alysha
Published: October 2024

Introduction:

More than 5 million children in the United States experience food insecurity (FI), yet little guidance exists regarding screening for FI. A prediction model of FI could be useful for healthcare systems and practices working to identify and address children with FI. Our objective was to predict FI using demographic, geographic, medical, and historic unmet health-related social needs data available within most electronic health records.

Methods:

This was a retrospective longitudinal cohort study of children evaluated in an academic pediatric primary care clinic and screened at least once for FI between January 2017 and August 2021. American Community Survey Data provided additional insight into neighborhood-level information such as home ownership and poverty level. Household FI was screened using two validated questions. Various combinations of predictor variables and modeling approaches, including logistic regression, random forest, and gradient-boosted machine, were used to build and validate prediction models.

Results:

A total of 25,214 encounters from 8521 unique patients were included, with FI present in 3820 (15%) encounters. Logistic regression with a 12-month look-back using census block group neighborhood variables showed the best performance in the test set (C-statistic 0.70, positive predictive value 0.92), had superior C-statistics to both random forest (0.65, p < 0.01) and gradient boosted machine (0.68, p = 0.01), and showed the best calibration. Results were nearly unchanged when coding missing data as a category.

Conclusions:

Although our models could predict FI, further work is needed to develop a more robust prediction model for pediatric FI.
Pager Explosion in Beirut: An Unprecedented Event
Authors: Helou Mariana , Weinstein Eric S. , Kalaji Joelle , Chaaban Toufic , Yammine Kaissar
Published: October 2024

On September 17, 2024, at 15:30 local time, thousands of pagers used by members of a specific party group detonated across Lebanon. As a result of the explosions, 2800 were wounded and 12 lost their lives. Almost two-thirds of the injuries were in the face, eyes, or hands. The Lebanese American University Medical Center received 38 injured and admitted 36 patients, 13 of them to the Intensive care unit. A total of 33 patients needed surgeries. All medical and nursing staff were deployed. The health care workers faced major challenges that night: the severity of the injuries and the unprecedented types of injuries with the same pattern, and the urgent need for ophthalmology and orthopedics within the hospital and across the country. Learning from the Pager Explosion, each hospital should perform assessments of their disaster response plan, develop trainings, and conduct regular exercises in preparation for future disasters.
Inhomogeneous isotropic quantum spin chain associated with the difference Lamé equation
Authors: van Diejen Jan Felipe
Published: October 2024

The spectrum and orthogonal eigenbasis are computed of a tridiagonal matrix encoding a finite-dimensional reduction of the difference Lamé equation at the single-gap integral value of the coupling parameter. This entails the exact solution, in terms of single-gap difference Lamé wave functions, for the spectral problem of a corresponding open inhomogeneous isotropic

$XY$

chain with coupling constants built from elliptic integers.
The Capital Region in the Unfinished Taiping War
Authors: Mokros Emily
Published: October 2024

In 1853, a Taiping army infiltrated North China, threatening Beijing and the Qing dynasty itself. Though this army never reached Beijing, its northern siege had acute and lasting impacts on communities in the capital region (jifu畿輔). Attention to the capital region invites reflection on the temporality and strategic nature of commemoration. Focusing on Cangzhou 滄州, I examine how capital region communities memorialized the northern chapter of the Taiping Civil War, even as for the rest of the empire, the war remained unfinished until 1864. In gazetteers, private histories, and commemorative records, local authors reframed ambiguous realities to write their localities into a story of northern victory, regardless of the fate of the south. The timeline for commemoration in Cangzhou was interrupted, not seamless, and took place over decades. Initially addressed to Beijing and elites along the Grand Canal, Cangzhou's commemorative project was later brought into the orbit of ascendant Tianjin.
How does ethical climate attract employees’ low-carbon behaviour? The role of environmental passion and green mindfulness
Authors: Kamil Nurul Liyana Mohd , Wan Mohamad Nordin Wan Noor Azreen
Published: October 2024

This study employs social cognitive theory to examine the dynamics of ethical climate, environmental passion, and low-carbon behaviours among Malaysian public servants based on data from 407 employees across 37 departments. Although ethical climate did not have a direct impact on low-carbon behaviour, a significant association with environmental passion was observed. Additionally, environmental passion exhibited a noteworthy relationship with low-carbon behaviour, and emerged as a mediator between ethical climate and low-carbon behaviour, with green mindfulness moderating this relationship. These findings underscore the importance of nurturing environmental passion and green mindfulness to promote low-carbon behaviour among employees and aid organisations in addressing environmental challenges. By addressing these empirical gaps, this study contributes to the literature on low-carbon behaviour and offers both theoretical insights and practical implications for sustainability initiatives.
The politics of medical expertise and substance control: WHO consultants for addiction rehabilitation and pharmacy education in Thailand and India during the Cold War
Authors: Kanazawa Reiko
Published: October 2024

This paper explores the role of World Health Organization (WHO) medical experts in ambitious projects for substance control during the Cold War in Thailand and India. The circumstances surrounding opium production in these two nations were very different, as were the reasons for requesting expert assistance from the United Nations. Whereas the Thai military regime was concerned with controlling illicit traffic to secure its borders, the Indian government wanted to direct its opium raw materials towards domestic pharmaceutical production. Overlapping and sometimes competing agendas of country governments and international agencies converged upon each project, complicating the consultants’ work and requiring careful navigation. In both cases, medicine as a science concerned with human health and well-being was subordinated to more pressing agendas. At the same time, the article argues that WHO consultants left an important impact, though not necessarily due to their skills and training in medicine. Instead, they provided exemplars of sound governance and delivery of public health in a politically stable and economically developed country.
Study on the relationship between KCNQ1 gene–environment interaction and abnormal glucose metabolism in the elderly in a county of Hechi City, Guangxi
Authors: Chen Shiyi , Li Hai , Huang Chuwu , Li You , Cai Jiansheng , Luo Tingyu , Liang Xue , Long Bingshuang , Wei Yi , Tang Jiexia , Zhang Zhiyong , Qin Jian
Published: October 2024

This study aimed to understand the potassium voltage-gated channel KQT-like subfamily, member 1 gene polymorphism in a rural elderly population in a county in Guangxi and to explore the possible relationship between its gene polymorphism and blood sugar. The 6 SNP loci of blood DNA samples from 4355 individuals were typed using the imLDRTM Multiple SNP Typing Kit from Shanghai Tianhao Biotechnology Co. The data combining epidemiological information (baseline questionnaire and physical examination results) and genotyping results were statistically analyzed using GMDR0.9 software and SPSS22.0 software. A total of 4355 elderly people aged 60 years and above were surveyed in this survey, and the total abnormal rate of glucose metabolism was 16·11 % (699/4355). Among them, male:female ratio was 1:1·48; the age group of 60–69 years old accounted for the highest proportion, with 2337 people, accounting for 53·66 % (2337/4355). The results of multivariate analysis showed that usually not doing farm work (OR 1·26; 95 % CI 1·06, 1·50), TAG ≥ 1·70 mmol/l (OR 1·19; 95 % CI 1·11, 1·27), hyperuricaemia (OR 1·034; 95 % CI 1·01, 1·66) and BMI ≥ 24 kg/m2 (OR 1·06; 95 % CI 1·03, 1·09) may be risk factors for abnormal glucose metabolism. Among all participants, rs151290 locus AA genotype, A allele carriers (AA+AC) were 0.70 times more likely (0.54 to 0.91) and 0.82 times more likely (0.70 to 0.97) to develop abnormal glucose metabolism than CC genotype carriers, respectively. Carriers of the T allele at the rs2237892 locus (CT+TT) were 0.85 times more likely to have abnormal glucose metabolism than carriers of the CC genotype (0.72 to 0.99); rs2237897 locus CT gene. The possibility of abnormal glucose metabolism in the carriers of CC genotype, TT genotype and T allele (CT + TT) is 0·79 times (0·67–0·94), 0·74 times (0·55–0·99) and 0·78 times (0·66, 0·92). The results of multifactor dimensionality reduction showed that the optimal interaction model was a three-factor model consisting of farm work, TAG and rs2237897. The best model dendrogram found that the interaction between TAG and rs2237897 had the strongest effect on fasting blood glucose in the elderly in rural areas, and they were mutually antagonistic. Environment–gene interaction is an important factor affecting abnormal glucose metabolism in the elderly of a county in Hechi City, Guangxi.
Determinants of the consumption of ultra-processed foods in the Brazilian population
Authors: Silveira V. N. C. , dos Santos A. M. , França A. K. T. C.
Published: October 2024

This article aims to evaluate the sociodemographic determinants of ultra-processed foods (UPF) consumption in the Brazilian population ≥ 10 years of age. The study used data from the personal and resident food consumption module of the Family Budget Surveys, grouping foods according to the NOVA classification of food processing. The classification and regression tree (CART) was used to identify the factors determining the lowest to highest percentage participation of UPF in the Brazilian population. UPF accounted for 37·0 % of energy content in 2017–2018. In the end, eight nodes of UPF consumption were identified, with household situation, education in years, age in years and per capita family income being the determining factors identified in the CART. The lowest consumption of UPF occurred among individuals living in rural areas with less than 4 years of education (23·78 %), while the highest consumption occurred among individuals living in urban areas, < 30 years of age and with per capita income ≥ US$257 (46·27 %). The determining factors identified in CART expose the diverse pattern of UPF consumption in the Brazilian population, especially conditions directly associated with access to these products, such as penetration in urban/rural regions. Through the results of this study, it may be possible to identify focal points for action in policies and actions to mitigate UPF consumption.
Unveiling the intrinsic role of malnutrition in patients with Crohn’s disease undergoing major surgery using entropy balancing weighting analysis
Authors: Taffurelli Giovanni , Montroni Isacco , Ghignone Federico , Zattoni Davide , Mazzotti Federico , Frascaroli Giacomo , Ugolini Giampaolo
Published: October 2024

The negative role of malnutrition in patients with Crohn’s disease is known; however, many coexisting disease-related factors could cause misinterpretation of the real culprit. This study aimed to describe the role of malnutrition using a novel methodology, entropy balancing. This was a retrospective analysis of consecutive patients undergoing elective major surgery for Crohn’s disease, preoperatively screened following the European Society for Clinical Nutrition guidelines. Two-step entropy balancing was applied to the group of malnourished patients to obtain an equal cohort having a null or low risk of malnutrition. The first reweighting homogenised the cohorts for non-modifiable confounding factors. The second reweighting matched the two groups for modifiable nutritional factors, assuming successful treatment of malnutrition. The entropy balancing was evaluated using the d-value. Postoperative results are reported as mean difference or OR, with a 95 % CI. Of the 183 patients, 69 (37·7 %) were at moderate/high risk for malnutrition. The malnourished patients had lower BMI (d = 1·000), Hb (d = 0·715), serum albumin (d = 0·981), a higher lymphocyte count (d = 0·124), Charlson Comorbidity Index (d = 0·257), American Society of Anaesthesiologists (d = 0·327) and Harvey-Bradshaw scores (d = 0·696). Protective loop ileostomy was more frequently performed (d = 0·648) in the malnourished group. After the first reweighting, malnourished patients experienced a prolonged length of stay (mean difference = 1·9; 0·11, 3·71, days), higher overall complication rate (OR 4·42; 1·39, 13·97) and higher comprehensive complication index score (mean difference = 8·9; 2·2 15·7). After the second reweighting, the postoperative course of the two groups was comparable. Entropy balancing showed the independent role of preoperative malnutrition and the possible advantages obtainable from a pre-habilitation programme in Crohn’s disease patients awaiting surgery.
Investigation of usage of antenatal care services by Syrian immigrant pregnant women and the frequency of anaemia and hypertension during the pandemic
Authors: Altaş Zeynep Meva , Sezerol Mehmet Akif
Published: October 2024

During the pandemic period, the use of health services by disadvantaged groups such as immigrants has deteriorated. The study aims to evaluate the use of antenatal care services by Syrian pregnant women during the pandemic. It is a cross-sectional type of study. The population consisted of 495 pregnant women who applied to the Extended Migrant Health Center (EMHC) between August 2020 and December 2022. Demographic data and pregnancy-related health records were examined through the system records, without any contact with the pregnant women. The percentage of pregnant women who had timely follow-up for each antenatal visit were 11.5% (n=56), 17.2% (n=80), 20.0% (n=88), and 17.4% (n=73), respectively. Only 17.7% (n=87) of the pregnant women made the recommended number of visits during their pregnancy period. The recommended number of follow-ups was statistically significantly higher in women with high-risk pregnancies (p=0.045). Of the pregnant women, 27.4% had anaemia and 2.4% had hypertension. The use of antenatal care in immigrant pregnant women is very low. Interventions are needed in this regard. Increasing the utilization of antenatal care services by immigrant pregnant women is extremely important for both the health of the pregnant woman and the health of the baby.
Shifting the spotlight: What do we mean by ‘religious language’?
Authors: Ellis David
Published: October 2024

There are mainly two types of questions asked about religious language: those about identity (e.g., what is a religious language?) and those about meaning (e.g., what do its sentences say?). Most philosophers focus on the latter because while they disagree about meaning, they agree that some sentences are religious and that our understanding of them does not depend on us knowing what makes them religious. In this article, I provide two reasons why questions about identity should receive more attention. First, theories of identity and theories of meaning share a two-way relationship where the characteristics of one influence those of the other, and so overlooking identity overlooks important characteristics of meaning. Second, the study of religious language has been shaped by this relationship for some time and being aware of it improves our understanding of conventional trends and contemporary debates. If successful, this article will motivate philosophers to reconsider the role of identity in research and to dedicate more effort to its study.
A novel online time calibration framework via double-stage EKF for visual-inertial odometry
Authors: Li Shuaiyong , Nie Jiawei , Guo Chengchun , Yang Yang , Mei Lin
Published: October 2024

There is an unavoidable time offset between the camera stream and the inertial measurement unit (IMU) data due to the sensor triggering and transmission delays, which will seriously affect the accuracy of visual-inertial odometry (VIO). A novel online time calibration framework via double-stage EKF for VIO is proposed in this paper. First, the first-stage complementary Kalman filter is constructed by adapting the complementary characteristics between the accelerometer and the gyroscope in the IMU, where the rotation result predicted by the gyroscope is corrected through the measurement of the accelerometer so that the IMU can output a more accurate initial pose. Second, the unknown time offset is added to the state vector of the VIO system. The estimated pose of IMU is used as the prediction information, and the reprojection error of multiple cameras on the same feature point is used as the constraint information. During the operation of the VIO system, the time offset is continuously calculated and superimposed on the IMU timestamp to obtain the data synchronized by the IMU and the camera. The Schur complement model is used to marginalize the camera state that carries less information in the system state, avoiding the loss of prior information between images, and improving the accuracy of camera pose estimation. Finally, the effectiveness of proposed algorithm is verified using the EuRoC dataset and the real experimental data.
Crystal structure of cariprazine dihydrochloride, C21H34Cl2N4OCl2
Authors: Kaduk James A. , Rost Megan M. , Dosen Anja , Blanton Thomas N.
Published: October 2024

The crystal structure of cariprazine dihydrochloride has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Cariprazine dihydrochloride crystallizes in space group P21/n (#14) with a = 27.26430(14), b = 7.29241(1), c = 12.80879(4) Å, β = 99.5963(2)°, V = 2511.038(8) Å3, and Z = 4 at 295 K. The crystal structure consists of layers of cations parallel to the bc-plane. The cations stack along the b-axis. Each H atom on the two protonated N atoms participates in a discrete N–H⋯Cl hydrogen bond. One Cl anion acts as an acceptor in two of these bonds, while the other Cl is an acceptor in only one bond. The result is to link the cations and anions into columns parallel to the b-axis. The powder pattern has been submitted to the ICDD for inclusion in the Powder Diffraction File™ (PDF®).
Informal digital learning of English in teachers: development and validation of a scale
Authors: Rezai Afsheen
Published: October 2024

Informal digital learning of English (IDLE) is a promising way of learning English that has received growing attention in recent years. It has positive effects on English as a foreign language (EFL) learners and also creates valuable opportunities for EFL teachers to improve their teaching skills. However, there has been a lack of a valid and reliable scale to measure IDLE among teachers in EFL contexts. To address this lacuna, this study aims to develop and validate a scale to measure IDLE for EFL teachers in Iran. For this purpose, a nine-step rigorous validation procedure was undertaken: administering pilot interviews; creating the first item pool; running expert judgment; running interviews and think-aloud protocol; running the pilot study; performing exploratory factor analysis, Cronbach’s alpha, and confirmatory factor analysis; creating the second item pool; conducting expert reviews; and performing translation and translation quality check. Findings yielded a 41-item scale with six subscales: IDLE-enhanced benefits (12 items), IDLE practice (five items), support from others (nine items), authentic L2 experience (three items), resources and cognition (four items), and frequency and device (eight items). The scale demonstrated satisfactory psychometric properties such that it can be used for research and educational purposes in future.
Magnetic resonance lymphangiography abnormalities as extracardiac biomarkers of pulmonary hypertension and functional phenotype in Fontan-Kreutzer univentricular circulation
Authors: Juaneda E. , Catalfamo D. , Fregapani J.P. , Guevara A. , Peirone A. , Juaneda I. , Kreutzer C. , Lucino S.
Published: October 2024

Introduction:

Lymphatic abnormalities have been documented on magnetic resonance lymphangiography in patients with functionally univentricular circulation.

Objective:

The aim of this study is to evaluate associations between findings on magnetic resonance lymphangiography, cardiac catheterisation and functional phenotype in patients with Fontan-Kreutzer circulation.

Materials and Methods:

Between January 2017 and October 2019, seven patients with Fontan-Kreutzer circulation (16.57 ± 7.10 years) were enrolled following ethical committee approval and attainment of informed consent. Clinical data, consecutive magnetic resonance imaging and cardiac catheterisation findings were reviewed. Qualitative lymphatic abnormality types were defined as: 1 – Little or none; 2 – Localised to the supraclavicular region; 3 – Extending into the mediastinum; and 4 – Extending into the lung. Pulmonary hypertension was defined as a transpulmonary gradient > 6 mmHg. Quantitative data were assessed using Mann–Whitney U tests, and p < 0.05 was considered statistically significant.

Results:

Patients with lymphatic abnormalities categorised type 1 or 2 and transpulmonary gradient ≤ 6 mmHg had a normal functional phenotype, while those with type 3 or 4 and transpulmonary gradient > 6 mmHg had a failing functional phenotype.

Conclusion:

Magnetic resonance lymphangiography in patients with Fontan-Kreutzer circulation and pulmonary hypertension revealed lymphatic abnormalities types 3–4, indicative of a failing functional phenotype compared to patients without pulmonary hypertension. If validated in larger studies, these results suggest the potential utility of this extracardiac biomarker for improving risk stratification. Integration of lymphangiography and transpulmonary gradient with functional class, atrioventricular valve function, and ejection fraction allowed for the categorisation of three distinct functional phenotypes, which may be valuable for future analyses.
Comorbidities, pharmacologic interventions, and mechanical interventions associated with mortality in isolated diastolic left heart failure: lessons from a national database
Authors: Loomba Rohit S. , Ikeda Nobuyuki , Farias Juan S , Villarreal Enrique G. , Flores Saul
Published: October 2024

Background:

Diastolic heart failure may be noted in paediatric patients with CHD, cardiomyopathy, or malignancies requiring chemotherapy, but the available data are scarce, and often derived from adult trials or based on theoretic or anecdotal evidence.

Methods:

Data between 2016 and 2021 were obtained from Pediatric Health Information System database. Patients <18 years of age with isolated diastolic heart failure admitted to ICU at some point during admission were included. They were divided into patients with and without inpatient mortality. Patients’ demographics, comorbidities using ICD-10 codes, and pharmacologic interventions were also recorded. Univariate analysis was done in demographics, comorbidities, pharmacologic interventions, and mechanical interventions between admissions with and without mortality. Multivariable logistic regression was done for inpatient mortality and multivariable linear regression was done for total hospital length of stay in survivors.

Results:

Isolated diastolic heart failure comprised 0.5% of critically ill paediatric patients. A total of 121 (5%) experienced mortality among the 2,273 admissions in the final analyses. Milrinone and angiotensin converting enzyme inhibitor were found to be associated with decreased mortality. Increasing age and diuretics were associated with decreased total hospital length of stay in survivors.

Conclusion:

In the cohort studied, isolated diastolic left heart failure has a 5% mortality. Several comorbidities and interventions are associated with increased mortality with milrinone and angiotensin converting enzyme inhibitors being associated with decreased risk of mortality. When only admissions with survival to discharge are considered, older age and diuretics are associated with lower total hospital length of stay.
Conventional vs. unconventional monetary policy under credit regulation
Authors: Kumar Ankit , Rao Rahul , Subramanian Chetan
Published: October 2024

We provide empirical evidence that the impact of quantitative easing (QE) programs on investment is weaker for countries with high-credit market regulations. We then extend a simple DSGE model with segmented financial markets to include credit regulation and examine its impact on the transmission of conventional and unconventional monetary policies. In our model, the government requires banks to hold a fraction of their assets in government debt. We show that the presence of such regulation can invert monetary transmission under QE policy: An expansionary QE program raises term premiums on corporate bonds and causes a contraction instead of an expansion in the economy. Such a perversion is absent under conventional policy. Further, in contrast to Carlstrom et al. (2017), we show that a simple Taylor rule welfare dominates a term premium peg under financial shocks, while the peg does better in the case of non-financial shocks.
Knowledge and beliefs about dietary inorganic nitrate in a representative sample of adults from the United Kingdom
Authors: Griffiths Alex , Grainger Evie , Matu Jamie , Alhulaefi Shatha , Whyte Eleanor , Hayes Eleanor , Brandt Kirsten , Mathers John C , Siervo Mario , Shannon Oliver M
Published: October 2024

Objective:

Evaluate knowledge and beliefs about dietary nitrate among United Kingdom (UK)-based adults.

Design:

An online questionnaire was administered to evaluate knowledge and beliefs about dietary nitrate. Overall knowledge of dietary nitrate was quantified using a twenty-one-point Nitrate Knowledge Index. Responses were compared between socio-demographic groups.

Setting:

UK.

Participants:

A nationally representative sample of 300 adults.

Results:

Only 19 % of participants had heard of dietary nitrate prior to completing the questionnaire. Most participants (∼70 %) were unsure about the effects of dietary nitrate on health parameters (e.g. blood pressure, cognitive function and cancer risk) or exercise performance. Most participants were unsure of the average population intake (78 %) and acceptable daily intake (83 %) of nitrate. Knowledge of dietary sources of nitrate was generally low, with only ∼30 % of participants correctly identifying foods with higher or lower nitrate contents. Almost none of the participants had deliberately purchased, or avoided purchasing, a food based around its nitrate content. Nitrate Knowledge Index scores were generally low (median (interquartile range (IQR)): 5 (8)), but were significantly higher in individuals who were currently employed v. unemployed (median (IQR): 5 (7) v. 4 (7); P < 0·001), in those with previous nutrition education v. no nutrition education (median (IQR): 6 (7) v. 4 (8); P = 0·012) and in individuals who had heard of nitrate prior to completing the questionnaire v. those who had not (median (IQR): 9 (8) v. 4 (7); P < 0·001).

Conclusions:

This study demonstrates low knowledge around dietary nitrate in UK-based adults. Greater education around dietary nitrate may be valuable to help individuals make more informed decisions about their consumption of this compound.
A Multiwavelength View of Black Holes and Outflows in Post-starburst Galaxies
Authors: Luo Yuanze
Published: October 2024

. Post-starburst galaxies (PSBs) have quenched (significant decline in star formation rate) both recently and rapidly (≲Gyr). They are thus promising in providing insights into activities that are happening at the early stage of quenching. While studies have suggested that black hole feedback in the form of active galactic nuclei (AGN) and outflows play important roles in quenching, the details of how they impact the host galaxies and their interplay with other quenching mechanisms are still not fully understood. We find that PSBs commonly show signatures of AGN activity but they appear to be weak and/or heavily obscured. These AGN might be able to drive outflows but they are likely not strong enough to remove gas from the host galaxy. Direct evidence of AGN quenching the star formation of the host galaxy is still missing and AGN likely quench by disturbing rather than expelling the gas.
Intermediate mass black hole feedback in dwarf galaxy simulations with a resolved ISM and accurate nuclear stellar dynamics
Authors: Partmann Christian , Naab Thorsten , Lahén Natalia , Churazov Eugene , Hislop Jessica M. , Rantala Antti , Johansson Peter H. , Hirschmann Michaela
Published: October 2024

Recent observations have established that dwarf galaxies can host black holes of intermediate mass (IMBH, 100Mȯ < MIMBH ≲ 105 Mȯ). With modern numerical models, we can test the growth of IMBHs as well as their evolutionary impact on the host galaxy. Our novel subsolar-mass (0.8 solar mass) resolution simulations of dwarf galaxies (M* = 2 × 107 Mȯ) have a resolved three-phase interstellar medium and account for non-equilibrium heating, cooling, and chemistry processes. The stellar initial mass function is fully sampled between 0.08–150 Mȯ while massive stars can form HII regions and explode as resolved supernovae. The stellar dynamics around the IMBH is integrated accurately with a regularization scheme. We present a viscous accretion disk model for the IMBH with momentum, energy, and mass conserving wind feedback. We demonstrate how the IMBH can grow from accretion of the cold and warm gas phase and how the presence of the IMBH and its feedback impacts the gas phase structure.
Testing AGN outflow and accretion models with SDSS quasar demographics
Authors: Temple Matthew J.
Published: October 2024

One commonly-invoked launching mechanism for AGN outflows is radiation line driving. This mechanism depends closely on the SED of the ionizing continuum, and so is inherently linked to the structure of the accretion flow. Theories of radiation line-driven winds therefore provide testable predictions as a function of black hole (BH) mass and accretion rate. In this work we confront these predictions using the ultraviolet emission line properties of 190,000 quasars from SDSS DR17. We quantify how the shape of CIV 1549Å and the equivalent width (EW) of HeII 1640Å depend on the BH mass and Eddington ratio inferred from MgII 2800Å. The blueshift of the CIV emission line is commonly interpreted as a tracer of quasar outflows, while the HeII EW traces the strength of the 10-100 eV continuum which photo-ionizes the ultraviolet emission line regions. Above L/LEdd > 0.2, there is a strong mass dependence in both CIV blueshift and HeII EW. Large CIV blueshifts are observed only in regions with both high BH mass and high accretion rate, consistent with predictions for radiation line driven winds. The observed trends in HeII and 2 keV X-ray strength are broadly consistent with theoretical models of AGN SEDs, where the ionizing SED depends on the accretion disc temperature and the strength of the soft excess. At L/LEdd < 0.2, we find a dramatic switch in behaviour: the ultraviolet emission properties show much weaker trends, and no longer agree with SED models, hinting at changes in the structure of the broad line region. Overall the observed emission line properties are generally consistent with the radiation line driving scenario, where quasar winds are governed by the SED, which itself results from the accretion flow and hence depends on both the SMBH mass and accretion rate.
Searching for outflows in X-ray weak quasars
Authors: Trefoloni Bartolomeo
Published: October 2024

The connection between X-ray weakness and powerful X-ray outflows is both expected in a scenario where outflows are connected with radiation-driven winds, and observed in several sources, both in the local Universe and at high redshift. Here I present the first results of a new study of this possible connection based on a search for SDSS quasars with weak X-ray emission in serendipitous XMM-Newton observations. The selected objects have a “normal” optical/UV blue continuum, but a flat and extraordinarily weak X-ray spectrum. The availability of rest-frame optical/UV spectra allows to check for the signature of outflows in the absorption lines and/or in the profiles of the emission lines. This method could reveal the presence of a population of so-far overlooked outflowing quasars and confirm the connection between winds and X-ray weakness in quasars.
AGN outflows and its variability
Authors: M Vivek , Nair Akhil , Mishra Sapna
Published: October 2024

The radiative mode of AGN feedback, operated through outflows, plays an essential role in the evolution of galaxies. Quasar outflows are detected as blue-shifted broad absorption lines in the UV/optical spectra of quasars. Thanks to the Sloan digital sky survey, 100,000 broad absorption line quasars are available now for ensemble statistical studies. This rich dataset has also enabled us to identify some peculiar cases of these sources. By quantifying the BAL fraction in radio-loud BAL quasars, our studies demonstrate a clear trend of increasing BAL fraction as the viewing angle approaches an edge-on orientation, favoring the orientation model of BAL quasars. Also, by contrasting the properties of BAL quasars with appearing and disappearing BAL troughs, our analysis suggests that the extreme variations in BAL troughs are driven by ionization changes.
Common Genetic Influence on the Relationship Between Gaming Addiction and Attention Deficit Hyperactivity Disorder in Young Adults: A Twin Study
Authors: Lee Seol-Ah , Hur Yoon-Mi
Published: October 2024

Although the relationship between gaming addiction (GA) and attention deficit hyperactivity disorder (ADHD) is well established, the causal mechanism of this relationship remains ambiguous. We aimed to investigate whether common genetic and/or environmental factors explain the GA-ADHD relationship. We recruited 1413 South Korean adult twins (837 monozygotic [MZ], 326 same-sex dizygotic [DZ], and 250 opposite-sex DZ twins; mean age = 23.1 ± 2.8 years) who completed an online survey on GA and related traits. Correlational analysis and bivariate model-fitting analysis were conducted. Phenotypic correlation between GA and ADHD in the present sample was 0.55 (95% CI [0.51, 0.59]). Bivariate model-fitting analysis revealed that genetic variances were 69% (95% CI [64%, 73%]) and 68% (95% CI [63%, 72%]) for ADHD and GA respectively. The remaining variances (ADHD: 31%; GA: 32%) were associated with nonshared environmental variances, including measurement error. Genetic and nonshared environmental correlations between ADHD and GA were 0.68 (95% CI [0.62, 0.74]) and 0.22 (95% CI [0.13, 0.30]) respectively, which indicates that shared genes can explain 82% of the phenotypic correlation between ADHD and GA. Our study demonstrated that the ADHD-GA association was largely due to shared genetic vulnerability.
A Distinct Role for Aerosol and GHG Forcing in Historical CMIP6 Evapotranspiration Trends
Authors: Egli Marius , Humphrey Vincent , Sippel Sebastian , Knutti Reto
Published: October 2024

Evapotranspiration (ET) is crucial for the global water balance, plant growth, and freshwater availability. It connects the surface water balance with surface energy fluxes, making its accurate representation vital for climate projections. However, global climate models (GCMs) struggle with ET representation due to resolution limitations and simplified depictions of soil, plant, and atmosphere interactions. Simulated future changes in ET are uncertain, and the role of driving processes remain unclear. Here, we explore the utility of a simple and interpretable method to disentangle these varying drivers. We investigate the sensitivity of JJA ET to different atmospheric variables through simple linear models predicting ET from atmospheric variables only. The model consistently yields good results across GCMs or forcing scenarios. We find that GCMs have shown strong decreases and subsequent increases in ET over the historical period, related to changes in net surface radiation. For future climate projections, decreases in water availability compete with higher available surface radiation, making future projections uncertain. Single forcing GCM realizations show that historical ET trends in densely populated regions have been more influenced by aerosol emissions than greenhouse gases. Finally, we investigate which atmospheric variables explain most short‐term (year‐to‐year) and long‐term (decadal) changes. While water availability may be the most important driver of short‐term variability, for certain regions, radiation trends dominate long‐term forcing. This paper leverages a simple approach to provide a comprehensive and understandable view into recent and future changes in ET, reconciling the evidence provided by more complex case studies.
Electron Temperatures in the Venusian Ionosphere From Parker Solar Probe Using Quasi‐Thermal Noise Spectroscopy
Authors: Tannous Speero M. , Bonnell John W. , Pulupa Marc , Bale Stuart D.
Published: October 2024

Parker Solar Probe (PSP) uses Venus gravity assists (VGA) to achieve the closest orbits to the Sun by a spacecraft. During the third (VGA3) and fourth (VGA4) Venus gravity assists, the PSP entered the Venusian ionosphere. The core electrons could not be detected as they were below the SWEAP/SPAN electrostatic analyzer instrument energy threshold. However, there is another way to estimate the core temperature using quasi‐thermal noise (QTN) data measured by the PSP/FIELDS Radio Frequency Spectrometer instrument. QTN spectroscopy offers an effective tool for measuring electron temperature and density when the electrons are too cold for other instruments to measure, as is the case with VGA3 and VGA4. Low‐frequency plasma wave data from the closest approach during VGA3 and VGA4 was analyzed with the QTN spectroscopy technique to determine the density and first‐ever in‐situ thermal electron temperature of the Venusian ionosphere at solar minimum.