bluuebunny/crossref_metadata_2025 huggingface dataset:
BAYESIAN IDENTIFICATION OF PYROLYSIS MODEL PARAMETERS FOR THERMAL PROTECTION MATERIALS USING AN ADAPTIVE GRADIENT-INFORMED SAMPLING ALGORITHM WITH APPLICATION TO A MARS ATMOSPHERIC ENTRY
Authors: Coheur Joffrey , Magin Thierry E. , Chatelain Philippe , Arnst Maarten
Published: November 2022

For space missions involving atmospheric entry, a thermal protection system is essential to shield the spacecraft and its payload from the severe aerothermal loads. Carbon/phenolic composite materials have gained renewed interest to serve as ablative thermal protection materials (TPMs). New experimental data relevant to the pyrolytic decomposition of the phenolic resin used in such carbon/phenolic composite TPMs have recently been published in the literature. In this paper, we infer from these new experimental data an uncertainty-quantified pyrolysis model. We adopt a Bayesian probabilistic approach to account for uncertainties in the model identification. We use an approximate likelihood function involving a weighted distance between the model predictions and the time-dependent experimental data. To sample from the posterior, we use a gradient-informed Markov chain Monte Carlo method, namely, a method based on an Ito stochastic differential equation, with an adaptive selection of the numerical parameters. To select the decomposition mechanisms to be represented in the pyrolysis model, we proceed by progressively increasing the complexity of the pyrolysis model until a satisfactory fit to the data is ultimately obtained. The pyrolysis model thus obtained involves six reactions and has 48 parameters. We demonstrate the use of the identified pyrolysis model in a numerical simulation of heat-shield surface recession in a Martian entry.
Bioactivity Profiling of Infusion, Decoction, and Hydroalcoholic Fraction Obtained from Wild Golden Chanterelle Mushroom, Cantharellus cibarius (Agaricomycetes)
Authors: Ghosh Sandipta , Basak Gouri , Saha Rituparna , Acharya Krishnendu
Published: November 2022

Cantharellus cibarius Fr. is one of the most desirable, popularly known wild edible mushrooms of the genus Cantharellus. Besides having nutritional benefits, this mushroom is reported to harbor significant medicinal potential. In present study, we describe for the first-time bioactive metabolites content and medicinal activities of three different types of extracts including infusion, decoction, and hydroalcoholic fraction from wild Cantharellus cibarius of West Bengal. Bioactive metabolites quantification revealed the phenol and flavonoids present in the range between 0.56-1.46 mg of GAE/g of dried fruit bodies and 0.12-0.29 mg of QE/g of dried fruit bodies, respectively, whereas ascorbic acid contents were also found. Antioxidant activity was assessed using six in vitro systems; decoction displayed better results in all investigated assays with EC50 values ranging between 0.05 and 0.34 mg/ml whereas hydroalcoholic extract showed highest total antioxidant capacity (18 ± 1.61 μg AAE per mg of extract) than other extracts. Moreover, infusion and decoction were found to scavenge highly reactive free radicals like hydroxyl and nitric oxide with their EC50 values ranging between 0.26 and 0.91 mg/ml. Additionally, anti-inflammatory potential of the extracts was evaluated using protein denaturation assay. Hydroalcoholic extract at a concentration range of 0.005-0.1 mg/ml showed comparatively better activity than decoction and infusion, although all the extracts presented dose dependent inhibition of heat induced protein denaturation. Altogether, the present investigation is expected to extend the existing knowledge of this species and recommended its use in pharmaceutical industries as an effective mycomedicine.
Evaluation of rockburst energy capacity for the design of rock support systems for different tunnel geometries at El Teniente copper mine
Authors: Villalobos F.A. , Villalobos S.A. , Aguilera L.E.
Published: November 2022

Rockburst events have been a serious problem for many years in many mines worldwide, and in particular at El Teniente mine in Chile. El Teniente is the largest copper mine in the world, located in the Andes Cordillera where high stress levels are present due to intensing mining activity in addition to complex geology. Consequently, the study and management of the rockburst threat are necessary. In this work, the case of the Diablo Regimiento (DR) mine within El Teniente is studied. The energy capacity of dynamic support systems is determined for different tunnel geometries based on two kinetic methodologies, using data from DR. Initially, rockburst potential is determined by means of a stress analysis around different tunnel geometries through the boundary elements method. In the first methodology a yielding zone (YZ) is estimated for each excavation geometry using the finite element method FEM. The second methodology involves the definition and determination of a critical strain energy (SE) around each excavation geometry using a FEM numerical analysis. In both cases, peak particle velocity PPV is estimated by a scaling law, which is subsequently adjusted due to tunnel amplification effects. According to the results, and knowing the working energy capacity applied in DR mine, it was found that the values of energy capacity for the rock dynamic supports were better estimated by the YZ-PPV approach than by the SE approach.
Determination of the stress state prior to excavation in an underground slate mine using flat jack and numerical methods
Authors: Alonso-Jiménez A. , Arlandi-Rodríguez M. , Lopez-Jimeno C. , García-Berrocal A.
Published: November 2022

Spain is a major producer of dimension stone, which is one of the most important industrial sectors in the northwest of Spain. This justifies the maintenance of these industries, although the technical and environmental requirements for their continuity are increasingly demanding. The main target of this paper is to present a new methodology in order to obtain k-ratio stress values on the basis of flat jack measurements and finite element numerical back- analysis with Rocscience© RS2 software. Continuous iterations were performed to try to find a relationship between the k0 and the measured stress in the tunnel roof and sidewalls. It focuses on technical aspects of the method for designing mine chambers in the slate industry that were previously mined by open pit methods. The size of the chambers impacts the operating cost, and the dimensioning of a correct support ensures better efficiency and safety. Correct knowledge of the k0 therefore is critical for the design of the support. The proposed new method entails a simplification of the classical procedure for estimating the k-ratio.
Collaboration and Diversity in STEM
Authors: Botha Z.
Published: November 2022

Sheryl Sandberg, the COO of Facebook, published a book titled 'Lean In', where she invites women to sit at the table. In summary, to 'sit at the table' entails not only embracing opportunity, but to actively seek out opportunities in leadership positions. Sandberg points out that, unfortunately, apart from institutional obstacles, a woman's own perceived limitations have a negative impact on her leadership ambitions. To create an environment where diversity will flourish, where everyone has a seat at the table and everyone has a voice, safety must be established first. To establish safety within a diverse team, there is power in relationships and connections.
Experimental confirmation of the concept of the photon spatial switch based on off-axis zone plate in the millimeter range
Authors:   Novosibirsk Division of the Institute of Rzhanov Semiconductor Physics of the Siberian Branch of the RAS, ", Paulish Andrey G. ,   TDIAM″,   Novosibirsk State Pedagogical University, Russian Federation,   Novosibirsk State University, Russian Federation, Minin Oleg V. ,   Siberian State University of Geosystems and Technologies, Novosibirsk, Russian Federation, Minin Igor V. ,   Siberian State University of Geosystems and Technologies, Novosibirsk, Russian Federation
Published: November 2022

The results of an experimental verification of the concept of the previously proposed all-optical wavelength-selective multichannel switch based on an off-axis Fresnel zone plate in the millimeter wavelength range without the use of micromechanical devices or non-linear materials are presented. A laboratory prototype of such a device is considered and its main parameters are discussed. It is shown that the optical isolation of switched channels for a switch based on an off-axis zone plate can reach 15 dB at a frequency difference of 25 GHz in the frequency range of 93–136 GHz.
Patterns of the Concurrent Use of Anti-dementia Drugs and Antipsychotics: Analysis using HIRA-APS-2018 Data
Authors:   The Pharmaceutical Society Of Korea, Kim Hea-Lim , Lee Hye-Jae
Published: November 2022

The number of dementia patients and the associated socio-economic burden are rapidly increasing in Korea. Behavioral and psychological symptoms of dementia increase the burden on caregivers, thus primarily instigating admission to a nursing home. In this study, using 2018 Health Insurance Review and Assessment Service-Aged Patient Sample (HIRA-APS) data, the pattern of concurrent use of anti-dementia and antipsychotic drugs by dementia patients was investigated, and related factors were identified. The most frequently used combination were donepezil-quetiapine (52.8%), donepezil-memantine-quetiapine (13.8%), and donepezil-risperidone (8.8%). Logistic regression analysis revealed male patients, those aged ≥75 years, medical aid beneficiaries, and those with Charlson Comorbidity Index (CCI) ≥5 to be more likely to receive concomitant administration. The likelihood increased in patients visiting nursing or general hospitals, while it decreased in patients visiting tertiary hospitals. Honam, Gyeongsang, and Chungcheong regions showed lower likelihood of concurrent use than Seoul-metropolitan area. The results of this study provide basic evidence for further studies on the outcome of concurrent use in dementia patients.
El impacto social desde los movimientos bottom-up: el caso de la Escuela de Personas Adultas La Verneda-Sant Martí
Authors: Gómez Cuevas Sara , Valls Rosa
Published: November 2022

Existen abundantes investigaciones sobre la participación comunitaria y acerca del debate sobre su promoción desde el poder institucional (top-down) o desde la propia ciudadanía (bottom-up). Sin embargo, hay un vacío en la literatura científica sobre los elementos claves que logran impacto social de la participación comunitaria promovida desde abajo (bottom-up). Este artículo presenta un estudio de caso de la Escuela de Personas Adultas la Verneda-Sant Martí, que lleva 44 años de existencia. Basándose en la metodología comunicativa, se han realizado entrevistas en profundidad a personas que han participado en el proyecto de la escuela. El principal hallazgo es que el liderazgo dialógico ha sido un elemento clave para el impacto social de esta escuela.
Street-Level Workers and the Construction of Social Infrastructure in Suburban Neighbourhoods
Authors: Kuoppa Jenni , Kymäläinen Päivi
Published: November 2022

The article examines the provision of social infrastructures in suburban neighbourhoods from the perspective of street-level workers. The concept of infrastructure is usually related to material and structural conditions but can equally apply to social infrastructures that are continuously constructed and maintained in social practices. These social infrastructures are embedded in structures and social arrangements and are related to past decisions. Our research focuses on the social infrastructures of two high-rise suburbs in Finland, built in the 1960s and 1970s. Since the 1990s, these neighbourhoods have experienced socioeconomic decline and transformation into a multicultural milieu. While suburbs have often been overlooked in urban politics and public discourses, a wide range of social infrastructures have also evolved in these districts and are continuously maintained. The main research data consists of interviews with street-level workers who participate in the production of such local social infrastructures. The article identifies and analyses the essential factors and preconditions as well as the challenges and contradictions of the provision of social infrastructure in these suburban contexts. This understanding is needed in order to foster an extensive social infrastructure and to deter counterforces from exacerbating socio-spatial inequalities and social polarisation in cities.
Ensuring the preservation of cultural values of the Garrison Church and the Church of Paraskeva in Lviv during the war
Authors:   Balkan History Association, Voloshchenko Stanislav , Shpak Arsen ,   Polonika The National Institute of Polish Cultural Heritage Abroad
Published: November 2022

The proposed article is devoted to the issue of preservation from possible damage to the national heritage of the Garrison Church of the Holy Apostles Peter and Paul (Jesuit Church or Society of Jesus), as well as the Church of St. Paraskeva Friday in Lviv during the Russian-Ukrainian war (2014 – present). Circumstances of the full-scale military invasion of the Russian Federation into Ukraine on February 24, 2022, necessitated the immediate need to protect the country's cultural heritage. The urgency of the security component of the preservation of art objects was dictated by missile attacks in almost all regions of Ukraine, including the Lviv region. The security measures in which the authors of the article took part were conditioned by the possibility of rocket attacks on sacred monuments of Lviv and the possibility of their damage by fire or mechanical damage. These cultural values include altars, wooden sculptures, decorative elements, organs, and objects on the canvas of the Garrison Church, as well as a six-row wooden iconostasis of the Church of St. Paraskeva. The specifics of the material of art objects, their size, location, and in part restoration work, made it difficult to evacuate and preserve them in new circumstances. The authors characterize the newly acquired experience of securing the heritage of the 17th – 20th centuries. refractory materials in the outlined Lviv religious buildings. The article deals with artefacts that have been protected from the effects of missile damage. The stages of monument protection work are covered, which first of all consist of selecting and classifying refractory and heat-resistant materials, team involvement, photo-fixing, marking, inventory of objects, and direct security of art objects. The authors express their recommendations for practical solutions in uncertain conditions. For the first time since the restoration of Ukraine’s independence, such a practice has been used in architectural monuments of national importance in Ukraine.
Cultural Heritage and the Problem of Prioritization
Authors:   Virginia Museum of Natural History, USA, Bassett Hayden , Harrell Kate ,   Virginia Museum of Natural History, USA, Koropeckyj Damian ,   Virginia Museum of Natural History, USA, Gunter-Bassett Madeleine ,   Virginia Museum of Natural History, USA, Welsh William ,   Virginia Museum of Natural History, USA
Published: November 2022

Monitoring impacts to cultural heritage during armed conflict or natural disaster has often relied on priority lists. These lists rank cultural properties by relative importance. While born from practical motivations, cultural heritage monitoring based on priority lists often fosters structural biases, selective preservation, and assumptions of shared values of significance. Recent cultural heritage monitoring efforts have taken an alternative approach that moves beyond prioritization. Rather than monitoring the highest priorities on a list of sites, this alternative approach uses technology to monitor many cultural properties simultaneously. Of the impacted sites identified using this alternative approach, only a small number would have been ranked on traditional priority lists. This includes sites of local significance, representations of regional or ethnic diversity, recent heritage sites, and rural heritage. In this essay, we advance a no-priority monitoring model, in which prioritization occurs at the intervention phase, rather than serving as the starting place. Eliminating prioritization as a starting place minimizes the potential for unobserved impacts, and as a result, the implicit decisions that must be made toward mitigating those impacts. We demonstrate the current value of this approach in monitoring cultural heritage in Ukraine.
Development of Decoding Abilities in Bosnian-speaking Children: a Two-year Follow-up Study
Authors: Memisevic H. , Malec D. , Dedic A.
Published: November 2022

Reading is one of the most important academic skills that children master in the early grades of elementary school. The simple view of reading postulates that it consists of decoding abilities and linguistic understanding. The present study aims to explore the development of decoding abilities in the Bosnian language in children from Grade 3 to Grade 5. We assessed the relationships between word reading and pseudoword reading as measures of decoding skills, and phonemic deletion task, rapid automatized naming (RAN) of letters, and RAN of objects as the predictors of decoding skills. The sample for this study comprised 36 children (16 girls, 20 boys). This study’s results showed a significant improvement in decoding skills from Grade 3 to Grade 5. The best predictor of word reading in Grade 5 was RAN of objects in Grade 3, followed by RAN of letters in Grade 3. On the other hand, the significant predictors of pseudoword reading in Grade 5 were RAN of objects and the phoneme deletion task in Grade 3. Understanding reading development from Grade 3 to Grade 5 is informative and can help create better reading instruction for all readers.
Deep Residual Adaptive Neural Network Based Feature Extraction for Cognitive Computing with Multimodal Sentiment Sensing and Emotion Recognition Process
Authors: Arora Gopal , Sabharwal Munish , Kapila Pooja , Paikaray Divya , Vekariya Vipul , T Narmadha
Published: November 2022

For the healthcare framework, automatic recognition of patients’ emotions is considered to be a good facilitator. Feedback about the status of patients and satisfaction levels can be provided automatically to the stakeholders of the healthcare industry. Multimodal sentiment analysis of human is considered as the attractive and hot topic of research in artificial intelligence (AI) and is the much finer classification issue which differs from other classification issues. In cognitive science, as emotional processing procedure has inspired more, the abilities of both binary and multi-classification tasks are enhanced by splitting complex issues to simpler ones which can be handled more easily. This article proposes an automated audio-visual emotional recognition model for a healthcare industry. The model uses Deep Residual Adaptive Neural Network (DeepResANNet) for feature extraction where the scores are computed based on the differences between feature and class values of adjacent instances. Based on the output of feature extraction, positive and negative sub-nets are trained separately by the fusion module thereby improving accuracy. The proposed method is extensively evaluated using eNTERFACE’05, BAUM-2 and MOSI databases by comparing with three standard methods in terms of various parameters. As a result, DeepResANNet method achieves 97.9% of accuracy, 51.5% of RMSE, 42.5% of RAE and 44.9%of MAE in 78.9sec for eNTERFACE’05 dataset.  For BAUM-2 dataset, this model achieves 94.5% of accuracy, 46.9% of RMSE, 42.9%of RAE and 30.2% MAE in 78.9 sec. By utilizing MOSI dataset, this model achieves 82.9% of accuracy, 51.2% of RMSE, 40.1% of RAE and 37.6% of MAE in 69.2sec. By analysing all these three databases, eNTERFACE’05 is best in terms of accuracy achieving 97.9%. BAUM-2 is best in terms of error rate as it achieved 30.2 % of MAE and 46.9% of RMSE. Finally MOSI is best in terms of RAE and minimal response time by achieving 40.1% of RAE in 69.2 sec.
The Effects of Cooking Temperatures and Times on the Formation of Aromatic Amines of Meatballs Derived from Sivas Province
Authors: CAN Özlem Pelin , DEMİR Ayşegül
Published: November 2022

In this study, nine different experimental groups were prepared by cooking meatball samples 5, for 7,5 and 10 minutes at 150, 200 and 250 ℃. Some chemical analysis including fat, protein, thiobarbituric acid contents and pH were applied to samples. The amount of Heterocyclic Aromatic Amines (HAA) of the samples treated byheat at 250 ℃ for 7,5 minutes had highest value, 0.42 ng/g. IQ (2-amino-3-metilimidazo[4,5-f]kinolin) and PhIP (2-amino-1-metil-6-fenilimidazo[4,5-b] piridin) were detected for the samples subjected to 250 ℃ heat treatment. HAA was not detected in the samples cooked at 7,5 for 10 minutes and 200 ℃, whereas MeQIx was found to be 0.17 ng/g for the samples baked for 5 minutes. Consequently, it was detected that the amount of HAA in all groups was below the 1 ng/g. which makespossible to comment chosen parameters for cooking meatballs is appropriate for formation of HAA.
Kinematic Analysis in 3-Dimensional Generalized Space
Authors: SAVCI Ümit Ziya
Published: November 2022

In this paper, we have first obtained the derivatives of spherical and spatial motions by using the special matrix group in generalized space E3(α,β). The rotation matrices and tangent operators were found by using derivatives of one- and multi-parameters motions in E3(α,β). Also, we obtained the angular velocity matrix of the moving body and its linear velocity vector. Finally, we gave some examples including applications of tangent operators and rotation matrices in support of our results.
Crif1 is Required for Proper Mesenchymal to Epithelial Transition
Authors: ALOTAİBİ Hani
Published: November 2022

The epithelial to mesenchymal and the mesenchymal to epithelial transitions (EMT and MET) are fundamental developmental processes required for shaping the embryo but are also hijacked by cancer cells during metastasis. The regulation of EMT is very well studied, and major regulators have been identified. A similar understanding of the regulation of MET is needed. Recently we and others have described essential factors for the initiation and progression of MET; among them is the ETS transcription factor Elf3. Recent reports showed that Crif1 is critical for the function of Elf3, yet the influence on MET has not been reported. Here, we studied the involvement of Crif1 in MET using a loss of function approach in NMuMG cells. We found that the depletion of Crif1 resulted in an impaired MET. We have also noticed that Cdh1 mRNA and protein expression was not affected; instead, E-cadherin, the protein product of Cdh1, was localized to the cytoplasm. These results are in agreement with our previous findings following the depletion of Elf3. In conclusion, Crif1 was essential for the mesenchymal to epithelial transition, and it may exert its function in cooperation with Elf3
Properties of J_p-Statistical Convergence
Authors: SÜMBÜL Canan , BELEN Cemal , YILDIRIM Mustafa
Published: November 2022

In this study, different characterizations of J_p-statistically convergent sequences are given. The main features of J_p-statistically convergent sequences are investigated and the relationship between J_p-statistically convergent sequences and J_p-statistically Cauchy sequences is examined. The properties provided by the set of bounded and J_p statistical convergent sequences is shown. It is given that the statistical limit is unique. Furthermore, a sequence that J_p-statistical converges to the number L has a subsequence that converges to the same number of L, is shown. The analogs of J_p statistical convergent sequences is studied.
In Silico Studies of Synthetic Sulfatide as a Potential Drug Candidate Against Covid-19
Authors: KOCABAY Samet , ALAGÖZ Mehmet Abdullah , BAKIR Hıncal Gökhan , AKKAYA Birnur
Published: November 2022

Sulfatides play various roles in many biological processes such as cancer metastasis, viral infections and regulation in nerve cells. The sulfatide molecules are related with hypertension diseases in which ACE2 (Angiotensin converting enzyme) is important for regulating blood pressure. ACE2 is also a key receptor for Covid-19 and highly expressed many different tissue types. Understanding the interaction between the sulfatides and ACE2 might be a key factor to develop potential novel treatments against Covid-19. Here we studied the interaction of main protease enzyme (6LU7) of Covid-19 with native sulfatide(A), chitosan based synthetic sulfatide(B) and inhibitor N3, through in silico studies such as molecular docking, molecular dynamics, ADMET prediction and target selection analysis. The compounds A, B and N3 bind the virus protease enzyme with docking score of -5.420, -6.009, -6.161 kcal/mol respectively indicates synthetic sulfatide binds better than native sulfatide and comparable to N3. Besides, molecular dynamics studies were carried out to reveal the stability of the complexes of interest. ADMET and target prediction studies carried out to reveal pharmacological properties and toxicity of the complexes and synthetic sulfatide found to be a drug-like molecule. We anticipate that computational investigation of virus interaction mechanisms will be an important starting point for experimental research in drug development efforts against Covid-19.
Quantum Chemical Benchmark Study on Valdecoxib, a Potent and Selective Inhibitor of COX-2, and its Hydroxylated Derivative
Authors: SERİN Sümeyya , DOĞAN ULU Öznur
Published: November 2022

In this work, quantum chemical calculations were performed on valdecoxib (VLB), a highly selective and potent COX-2 inhibitor, and its hydroxylated derivative (1H-VLB), an active metabolite. The geometry optimizations and frequency calculations were carried out by using density functional theory (DFT)/B3LYP functional with the 6-311++G (d, p) basis set. To define water phase behaviors, calculations were renewed by using universal SMD solvation model for both molecules. Structural and thermodynamic parameters, FT-IR analysis, Mulliken population analysis (MPA), frontier molecular orbital (FMO) analysis, natural bond orbital (NBO) analysis, and electrostatic surface properties were investigated in detail. Quantum chemical reactivity identifiers were calculated separately for both vacuum and water environment in order to evaluate the bioactivity tendency of both mentioned compounds. When the bioactivity of VLB and 1H-VLB molecules were compared based on quantum chemical reactivity identifiers, it was observed that the VLB molecule was more active. Moreover, drug-likeness properties of studied molecules were predicted by means of Molinspiration cheminformatics software. Molecular lipophilicity potential (MLP) maps that exhibit the accumulative lipophilic contributions of each atom in studied molecules were visualized.
Investigation of In Vitro Effect and Molecular Docking of Aluminum on Glucose-6-Phosphate Dehydrogenase Activity
Authors: ÜLGER ÖZBEK Dilara , KURUÇAY Deniz
Published: November 2022

Aim: Aluminum is one of the elements that is widely used in many sectors and is the most abundant element in nature. The harm of aluminum, which was thought to be harmless until recently and is actively used in daily life, is open to discussion. In this study, it was aimed to investigate the effect of Aluminum Sulphate [Al2(SO4)3] on Glucose-6-Phosphate Dehydrogenase (G6PDH) activity, which is a key enzyme that catalyzes the first step of the pentose phosphate pathway (PFP). In addition, enzyme activity are detailed with molecular docking studies. For the purpose of examining in vitro effect of Aluminium on G6PDH, 4 different concentration of substrate (D-glucose-6-P) (01.M, 0.08M, 0.05M, 0.03M) prepared and 10mM, 30mM Al2(SO4)3 was added G6PDH envoriment. G6PDH activity was measured by spectrofotometrically. Molecular docking studies were performed with DockingServer and HEX 8.0.0 programs. With the data obtained, the Vmax of G6PDH was calculated as 3.33 and Km=0.0323. When 10 mM and 30mM Al2(SO4)3 were added to the reaction environment, it was observed that there was a decrease in enzyme activity by 24.92% and 57.06%, respectively. It was observed that the increase in Al2(SO4)3 concentration was an uncompetitive inhibition due to a significant decrease in both Km and Vmax values of the enzyme.
Preclinical study of pharmacokinetic ADME processes of phenosanic acid in vitro and in vivo
Authors: Kosman Vera M. , Karlina Marina V. , Tyutina Ksenia V. , Makarov Valery G. , Makarova Marina N. , Morozov Sergey V. , Gushchina Eugenia E. , Zhuravskaya Natalia V.
Published: November 2022

BACKGROUND: Phenosanic acid is a synthetic antioxidant, the active ingredient of the original domestic drug recommended for the treatment of epilepsy. To improve the effectiveness and safety of the use of phenosanoic acid, additional study of its pharmacokinetic properties is necessary.
AIM: To study the pharmacokinetic parameters of the active ingredient of the drug Dibufelon, capsule 200 mg (LLC Piq-Pharma, Russia) in vitro and in vivo systems in rats after single administration in one dose.
MATERIALS AND METHODS: Phenosanic acid binding to blood plasma proteins, microsomal stability and permeability through the monolayer of Caco-2 cells were evaluated in in vitro tests. The pharmacokinetics parameters were studied after a single intragastric administration in Wistar rats in dose of 80 mg/kg. The samples were analyzed by HPLC-UV.
RESULTS: A high variability in the degree of binding of phenosanic acid to blood plasma proteins by 2065% depending on the concentration was revealed, relatively high microsomal stability (half-life 1106 789 min, internal clearance 2.05 0.86 l/min/mg protein of liver microsome; residual content after 60 min incubation 87.9 7.8%) and the ability to penetrate through the monolayer of cells Caco-2. The rapid absorbtion of the substance into the systemic bloodstream was established its maximum concentration in blood plasma was observed already 3.6 1.2 hours after administration, and its slow removal from the systemic bloodstream the half-life was about 19 h, the average retention time was about 29 h. Phenosanic acid with different degrees of intensity was distributed to all the examined organs and tissues: kidneys liver brain omentum muscle, and invariably excreted in a small amount with urine and feces, about 0.04% and 5.5%, respectively.
CONCLUSIONS: As a result of the study, it was found that phenosanic acid is characterized by rapid absorbtion into the systemic bloodstream and a long stay in it invariably, which may be due to the peculiarities of its binding to blood plasma proteins and relatively high metabolic stability, revealed during the corresponding in vitro tests. The study of the permeability and transport of phenosanic acid showed that it can presumably be attributed to compounds with medium permeability and is not a substrate for the transport protein P-glycoprotein (P-gp). The study of tissue availability of phenosanic acid confirmed its entry into peripheral tissues, including the brain, which is the area of implementation of the anticonvulsant effect.
XVIII. YÜZYILDA TUNA NEHRİ KIYISINDA BİR HUBUBAT MERKEZİ: İSAKÇI AMBARLARI
Authors: FİDAN Fadimana
Published: November 2022

Osmanlı Devleti, Tuna Nehri’nin kıyısında bulunan verimli arazilerden, Eflâk ve Boğdan’dan satın aldığı hububatı ihtiyaç durumunda kullanılmak üzere İsakçı ambarlarında depoladı. Tuna’nın geçilmesi en kolay yerinde bulunan İsakçı’dan gemilere hububat kolaylıkla yüklenebilmekteydi. İsakçı’nın bu özelliği iskele yakınında pek çok ambarın yapılmasını sağladı. XVIII. yüzyıl boyunca İsakçı’da tahrip olan, yeniden inşası gereken ya da hububat depolamada yetersiz gelen ambarların inşa faaliyetleri süreklilik arz etti. Ambar inşası bölgede pek çok insan için ekonomik bir kaynak oldu ve bu inşa faaliyetleri yoğun bir organizasyonu beraberinde getirdi. Bu çalışma XVIII. yüzyılda İsakçı’daki ambar inşa faaliyetleri hakkında bilgi vermekte ve burada stoklanan hububatın sınırda özellikle Rus tehdidi altındaki Karadeniz kalelerine gönderilmesi üzerinde durmaktadır. Böylelikle devletin sınırları koruma altına alırken iaşe anlamında askerin sıkıntı çekmesinin önüne geçmek için yoğun bir çaba içinde olduğu vurgulanmaktadır.
Female genital tuberculosis
Authors: Singh Saurabh Kumar , Gupta Mitali , Yadav Pratibha
Published: November 2022

Female genital tuberculosis (FGTB) is a common health problem in developing countries. It frequently causes pelvic inflammatory disease, menstrual abnormalities and infertility. It represents 15-20% of extrapulmonary tuberculosis. It is mostly secondary infection acquired from hematogenous spread from extra-genital source such as pulmonary or abdominal tuberculosis. The fallopian tube is affected in almost all the cases followed by endometrium and cervix. It occurs in the most economically productive age of 15-45 years causing infertility in 44-74% of individuals affected. The clinical diagnosis of genital TB requires a high index of suspicion. Infertility and menstrual irregularities are the commonest presentation. Diagnosis requires a multi-modality approach involving clinical, radiological, bacteriological, molecular and histopathological methods. Treatment requires the combination of four drugs (Rifampicin, Isoniazid, ethambutol and pyrazinamide) for a minimum of six months duration. In case of drug resistant tuberculosis reserve drugs are used for the extended period.
High BMI causing poor outcome of intrauterine insemination method
Authors: Baldawa Pratibha , Baldawa Sampat
Published: November 2022

To assess whether high BMI of >30kg/m2 affects outcome of Intrauterine Insemination method(IUI).

We conducted a retrospective study of 140 infertile couples. Out of these 71 women had BMI <30 (Group A) and 69 women had BMI of >30 (Group B). All these 140 women had undergone Intrauterine Insemination (IUI) using the agonist/antagonist with stimulation by gonadotrophins protocol.

Statistical anylasis was done by Student t test for parametric data and Chi-square test for p value significance.

We found that success of Intrauterine Insemination (IUI) was higher in women with BMI < 30. We had 16 pregnancies (22.54%) with 3 patients having twin pregnancy (4.23%) in Group A and only 3 patients (4.34%) were pregnant in the group B.

There was a significant (p = 0.002) decrease in pregnancy rate in women with BMI of >30 who underwent Intrauterine Insemination(IUI).
A study of postnatal depression in a tertiary care centre – A prospective observational study
Authors: Preethi Bhuvana , Vijayakrishnan Mala , Nagarajan Prasanth
Published: November 2022

Postnatal depression is defined as non-psychotic depressive episodes of mild to major severity which occurs during pregnancy or postpartum. It is one of the most common non obstetric disorders that causes significant morbidity in women during the perinatal period. It is often unrecognized, but an extremely common yet a disorder (100-150 per 100 births) and is prevalent among Indian women up to 19% - 22% as well. The aim of this study is to find out incidence of postnatal depression in Vijaya Hospital, a private tertiary care hospital.

This study aims at identifying the incidence of postnatal depression in postnatal mothers in a tertiary care centre using Edinburg Postnatal Depression Scale (EPDS) questionnaire and the risk factors contributing to postpartum depression. The results were incidence of postnatal depression at week one was 40% and week four was 27%.

: It is a prospective observational study with a sample size of 100. Postnatal mothers were screened using EPDS questionnaire at one week when they are admitted in hospital and four weeks when they come for postnatal checkup. Women with EPDS score of 13 and above was considered having Postpartum Depression. Age, socioeconomic status, educational status, employment status, type of family, menstrual history, premenstrual syndrome, obstetric score, mode of delivery, planning of pregnancy, relationship with parents, in laws and partner was compared at one week and four weeks.

The Primary outcome of the study was to measure the incidence of PPD at week one which was 40% and week four which was 27%. The secondary outcome identified the risk factors contributing to PPD in my study was menstrual history, mode of delivery, relationship with in laws, lack of partner support which was found to be statistically significant.

In my study done in a private tertiary care hospital, the cumulative incidence of PPD was 52%. Delivery through Caesarean section, menstrual history and poor relationship with in laws at one week was found to be statistically significant with a p-value of <0.05. Lack of partner support at one week and four weeks were found to be statistically significant with a p- value of < 0.05.
Functional and cosmetic outcome in oculofacial trauma at tertiary center- multidisciplinary approach
Authors: Ramnani Vinita , Ramnani Sakshi , Rathore Sunil , Sharma Nupun
Published: November 2022

To assess the outcome of lid, adnexal and orbital injuries in poly trauma patients at multi specialty hospital.

Papers of 104 consecutive patients with oculofacial injuries were retrospectively reviewed. Data were analyzed with respect to extent, severity, type and location of oculofacial injury. Treatment outcome assessed after surgeries performed by combined approach of ophthalmologist and plastic surgeon.

Periorbital soft tissue trauma observed in 65 (62.5%), orbital and Periorbital fracture in 39 (37.5%) cases and Intraocular injuries were noted in 43 patients (41.35 %). Accompanying other injuries was managed properly for better final outcome. Goal of repair is to restore anatomical and cosmetic appearance of patients. In our series of patients, we achieved 95% cosmetic satisfaction with loss of 5 eyes vision with best of our care.

The oculofacial trauma patients have tremendous fear of visual loss and aesthetic appearance. Functional and cosmetic outcome of oculofacial injuries depends on multiple factors, well planned, appropriate, early intervention by multidisciplinary approach provides best surgical outcome.
Bilateral ocular surface squamous neoplasia in xeroderma pigmentosum patient - A case report
Authors: G Sivaraman , Pandharpurar Modini
Published: November 2022

A rare case of a 13yr old male patient presented with photophobia in both eyes and gradually progressive painless mass with watering, itching, and redness in the right eye for 2 months. Best-corrected visual acuity in Right eye 20/200 and Left eye 20/120. On examination, Right eye has a 6 x 6 mm fleshy pink oval pedunculated mass lesion arising from the temporal limbus and a 2mm hyperpigmented lesion in the nasal limbus. Left eye has a gelatinous white flat diffuse lesion with the pigmentation of 3mm both in the nasal and temporal limbus. Both eyes' Anterior segment, ocular motility, and fundus are normal. The patient had multiple hyperpigmented spots (freckles) and scaly skin on the face and trunk suggestive of Xeroderma pigmentosum for which he was on irregular treatment. Right eye tumor mass was excised with intraoperative control of surgical margins with adjunctive cryotherapy and sent for histopathology examination, which was confirmed as squamous neoplasia. Postoperatively, Both eyes started on Topical Mitomycin-c 0.02% 4 cycles, and the patient was carefully followed for any recurrence.
Semantic Field of Concept «Reason» in XVIII Century Aesthetic Thought (on A. Popes’ Works)
Authors:   Yuri Gagarin State Technical University of Saratov, Kiryushkina V. V.
Published: November 2022

This work concerns revealing basic signatures of the concept «reason» (wit, judgment, understanding, sense etc.) and their semantic interrelations in aesthetic discourses of XVIII. The analysis is made on the basis of the works of Pope on art criticism. The author notes that in the English lexicon of the first half of XVIII century «reason» united around itself majority of concepts denoting cognitive and creative activity of a person.
The Balkans in Perception of Russian in Second Half XIX Century: Slavic Unity and Alienation
Authors:   Yuri Gagarin State Technical University of Saratov, Romashov Y. V.
Published: November 2022

In the article the issue of a contradictory perception of Balkan Slavs by Russians in the second half of 19th century is considered. On the one hand, the idea of Slavic unity has become stable in Russia which was actively supported by many Russian social and political public figures. On the other hand, when directly contacted Russians and southern Slavs appeared to be alienated and far from mental solidarity.
Commercial Relations of Settlement Beregovoy 4 (on Materials of Ceramic Containers)
Authors:   Saratov State University, Kuznetsova E. V.
Published: November 2022

In article economic relations of the Settlement Beregovoy 4 located on Fontalovsky peninsula in Temruk area of Krasnodar region are considered. The analysis of a mass archaeological material with application of methods of mathematical statistics has allowed to reconstruct dynamics of import of the goods from the different industrial centres from the end VI to the middle of III century BC.
Prácticas de derecho al agua en el barrio El Faro de Medellín ¿Una alternativa al desarrollo?
Authors: Botero-Mesa María
Published: November 2022

Es innegable que nos encontramos en una profunda crisis civilizatoria, la cual afecta todas las esferas de la vida humana y no- humana: social, económica, ambiental, política, cultural, espiritual, etc. En este contexto, las ciudades se erigen como espacios paradójicos. Por un lado, desde los preceptos del sistema capitalista neoliberal dependen de la insaciable extracción de la naturaleza en lugares lejanos, de la fuerza laboral precaria inclusive a veces forzada, de amplias áreas de tierras, de fuentes de agua, de bosques, de energía, de minerales, de muchas otras especies de animales, etc. Por otro lado, se configuran también espacios de solidaridad y de resiliencia que, reconociendo la diversidad del ecosistema urbano, reclaman justicia epistémica, social, ambiental, económica, es decir vivir con dignidad en espacios sustentables. El agua entendida por el sistema económico dominante como mercancía es central para el modelo de acumulación altamente inequitativo que se viene promoviendo. Debido a la negación de los límites ecosistémicos planetarios y al fuerte énfasis en una racionalidad instrumental, colonial y patriarcal, la lógica consumista termina produciendo muchas veces destrucción, contaminación y muerte.
Dynamique Spatio-temporelle de la Mangrove du bas Delta du Fleuve Sénégal de 1980 à 2021: Approche par Télédétection et Système d’Information Géographique
Authors: Dieng Dah , Sow Moussa , Sow El Hadji , BA Taibou
Published: November 2022

Le bas delta du fleuve Sénégal est une zone d’intérêt écologique au regard de la pluralité d’aires protégées qui sont localisées. Ce milieu, qui se caractérise par la diversité de ses ressources naturelles, développe une très grande vulnérabilité imputable à des causes aussi bien naturelles qu’anthropiques. Depuis quelques décennies, cette fragilité du milieu se répercute sur la mangrove qui assume difficilement ses fonctions socioéconomiques et écologiques. Dès lors, il convient d’analyser la dynamique spatiotemporelle de cet écosystème afin de comprendre les facteurs qui interviennent dans sa dégradation. Dans cette étude, l’objectif a été atteint au moyen de la télédétection à travers le traitement d’images satellitaires Landsat 1980 et 2000, Sentinel 2021 combiné à des travaux de terrains. Cela a permis la réalisation de cartes d’occupation du sol et de cartes de changements. Les résultats démontrent une tendance globale à la hausse de la mangrove avec des espaces couverts qui sont passés de 1 105,82 ha en 1980 à 1 482,32 ha en 2021 malgré une perte de superficies de 166,92 ha sur cette période.
Rendimiento Laboral del Personal de Salud Mental Relacionado con el Riesgo Psicosocial
Authors: López María Teresa Torres , Fuentes Martha Patricia Quintero , Rosas Liliana Fuentes , Ramírez Julieta Hernández
Published: November 2022

Los riesgos psicosociales impactan negativamente el rendimiento laboral; el objetivo de este estudio es determinar la asociación del rendimiento laboral con los riesgos psicosociales en personal de una unidad de salud mental. El estudio es cuantitativo, no experimental, transversal, con alcance correlacional y comparativo. La muestra es de 104 colaboradores de la unidad de salud mental. El rendimiento laboral se evaluó con el cuestionario individual de rendimiento laboral auto percibido de Koopmans y el riesgo psicosocial se evaluó con el cuestionario de evaluación de riesgos psicosociales en el trabajo SUSESO/ISTAS 2I versión corta. El coeficiente de correlación de Spearman indico que las dimensiones del riesgo psicosocial tienen una relación negativa o nula con el rendimiento laboral, excepto con la dimensión de comportamientos contraproducentes donde presenta una relación positiva; la prueba de U de Man Whitney mostró que no existe diferencia estadísticamente significativa entre rendimiento laboral y género. Se concluye que las demandas de la carga laboral del trabajo activo y apoyo social deben monitorearse en el personal de salud, debido a que tienen mayor impacto en el rendimiento laboral. El género no influye en el rendimiento laboral, mostrando igualdad de desempeño entre hombres y mujeres.
La Contabilidad Ambiental y Revelaciones de Empresas
Authors: Anaya María de los Ángeles Aguilar , Ramírez Diego Armando García , Sánchez Blanca Tapia
Published: November 2022

La contabilidad ambiental tiene como objetivo medir el impacto que las actividades de una organización generan en el medio ambiente. Existen organismos que han mostrado interés en analizar la manera en cómo las empresas adoptaran la contabilidad ambiental en sus reportes financieros. De igual manera, algunas empresas como Bimbo, Grupo Minsa y Gruma han tomado iniciativas para erradicar el desgaste ambiental cumpliendo con requisitos sustentables y ambientales. El presente trabajo analiza a través de una revisión documental, cómo empresas han adoptado el lenguaje de la contabilidad ambiental en sus reportes financieros o en su agenda. Para ello, se analizó información relacionada a la contabilidad ambiental, el desarrollo sostenible y los reportes de las empresas pertenecientes a el giro industrial en México.
Online Reviews by Beauty Vloggers of Local Lipsticks Product Impact on Purchase Intention
Authors: Octaffiana Elda , Rahmiati Filda , Genoveva Genoveva
Published: November 2022

Lipstick is a necessity for all women, yet many Indonesian women continue to favor international brands since they are more familiar. The local cosmetics business is rising fast, but it has obstacles, such as a strong demand for premium or high-brand cosmetics, such as Korean items, which remain popular among young women in Indonesia. Today, beauty vloggers are regarded as a reputable source of information on a certain cosmetics product. The purpose of this study is to explore the effect of competence, trustworthiness, and beauty on the purchase intention of a local lipstick product, as mediated by customer attitude and persuasive talents. This study adopts a quantitative methodology, gathering data using an online survey platform from participants (Google Form). Researchers collected 146 questionnaires from Greater Jakarta women who had viewed YouTube beauty vlogger reviews and reside in Jakarta. In this research, SEM-PLS is utilized to test hypotheses and analyze data. It has been discovered that knowledge, dependability, and beauty have a considerable impact on purchase intent, as mediated by consumer attitude. When a beauty vlogger recommends a local product's lipstick, persuasive talents have a large direct impact on consumer purchase intentions.