bluuebunny/crossref_metadata_2025 huggingface dataset:
Display Selection of a Hybrid Foldamer-Peptide Macrocycle
Authors: Dengler Sebastian , Howard Ryan T. , Morozov Vasily , Tsiamantas Christos , Liu Zhiwei , Dobrzanski Christopher , Pophristic Vojislava , Brameyer Sophie , Douat Céline , Suga Hiroaki , Huc Ivan
Published: February 2022

A helical aromatic foldamer was identified that undergoes tRNA acylation by a flexizyme and ribosomal peptide initiation with yields sufficiently high to perform an mRNA display selection of macrocyclic foldamer-peptide hybrids. A hybrid macrocyle binder to the C-lobe of the E6AP HECT domain was selected that showed highly converged peptide residues. A crystal structure and molecular dynamics simulations revealed that both the peptide and foldamer are helical in an intriguing reciprocal stapling fashion. The strong residue convergence could be rationalized based on their involvement in specific interactions. The foldamer stabilizes the peptide helix through stapling and through contacts with key residues. It appears to also contribute to protein binding by direct protein interactions. The results altogether highlight possible benefits in inserting an aromatic foldamer into a peptide macrocycle for the purpose of protein recognition.
Consumption of game and pest species by small-and medium-sized carnivores
Authors: Van Den Berge Koen , Van Den Berge Sanne , Van der Veken Timo , Gouwy Jan , Verschelde Pieter , Eeraerts Maxime
Published: February 2022

Ecosystem services are the contributions that natural ecosystems make to people. Mammalian carnivores can provide both positive and negative ecosystem services by consuming pest or game species, respectively. In this study, we determined the consumption of certain game and pest species for a guild of sympatric small- and medium-sized carnivores (European badger, red fox, European polecat, stone marten, stoat and least weasel). We found that game and pest species comprise a notable proportion of the diet, ranging from 0.0% to 12.6% and from 2.7% to 46.3%, respectively. Furthermore, for all carnivores we found that the proportion of pest species such as rats and voles (i.e., positive ecosystem service) was higher than the proportion of game species such as pheasants, partridges and hares, i.e., negative ecosystem service). Moreover, stoat and weasel did not consume any game species. This study gives a first overview of the potential ecosystem services through consumption of pest and game species provided by small- and medium-sized carnivores.
HUBUNGAN ORIENTASI, PARTISIPASI POLITIK TERHADAP PERILAKU PEMILIH DALAM PILKADA WALIKOTA KUPANG 2017
Authors: Juliansyah Andry
Published: February 2022

This research looks at the relationship between independent and dependent variables, with the formulation of the problem is: (1) the relationship of Political Orientation to Voter Behavior (2) the relationship of Political Participation to Voter Behavior (3) the relationship of Political Orientation to Voter Political Participation (4) the relationship of Political Orientation and Political Participation to Voter Behavior. The approach used in this study is a quantitative approach, while the data collection techniques used were, questionnaire and documentation study. Result of the study (1) Variable X1 to variable Y r value 0,237 is a positive relationship,
Analisis Social Ecology System-Action Situation untuk Kerangka Kerja Memulihkan Bumi
Authors: Aur Alexander
Published: February 2022

Paus Fransiskus mengeluarkan Ensklik Laudato Si’ pada 24 Mei 2015. Berbasis pada hasil riset ilmu pengetahuan ilmiah mengenai aneka problem lingkungan hidup di berbagai belahan dunia, Paus menghimbau kepada umat Katolik seluruh dunia agar memulihkan bumi dari tindakan manusia yang merusak alam. Memulihkan bumi sebagai rumah bersama. Ensiklik ini mendapat tanggapan luas dari berbagai kalangan. Berbagai pihak menaruh perhatian terhadap ensiklik ini. Artikel ini merupakan tanggapan terhadap ensiklik tersebut. Penulis menganalisis artikel 138, yang dalam ensiklik ini berada pada Bab IV yang berjudul “Ekologi Integral”. Untuk menganalisis artikel 138, penulis menggunakan, pertama, pendekatan social ecology system-action situation (SES-AS) sebagai metode analisis. Kedua, beberapa model pendekatan terhadap alam sebagai kerangka teoritik untuk memperdalam ekologi integral. Dengan demikian, Laudato Si’ memperoleh kerangka kerja aplikatif dan teoritik. Kerangka kerja aplikatif untuk aksi konkret. Kerangka teoritik untuk refleksi atas aksi konkret.
Endovascular treatment of common hepatocellular carcinoma: the experience of one center
Authors: Kondratiuk V.A. , Mazanovych I.A.
Published: February 2022

Objective ‒ to determine the place of transarterial chemoembolization of the liver (TACE) in the modern protocol for treating patients with common hepatocellular carcinoma and by optimizing indications and contraindications to improve the results of complex treatment of these patients.Materials and methods. During the period 2011‒2021 242 TACE procedures were performed on 112 patients with inoperable hepatocellular carcinoma. Conventional lipidol embolization (c-TACE) was performed in 53 patients, procedures with drug eluting beads (DEB-TACE) ‒ in 58. All patients underwent a minimum of 1, a maximum of 5 TACE procedures. The decision to re-TACE was made individually, according the prevalence of the lesion (for bilobar lesions performed at least 2 unilobar TACE) and the tumor’s response to the intervention. Results. TACE results were evaluated according to mRECIST criteria: complete tumor response (CR) was noted in 3 (2.7 %) cases, partial (PR) ‒ in 68 (60.7 %) cases, process stabilization (SD) ‒ in 29 (25.9 %), progression (PD) ‒ 12 (10.7 %) cases. According by the obtained results, convincing data for the superiority of any of the applied TACE methods were not found. Repeated TACE courses increase the overall effectiveness of the treatment. Conclusions. The use of TACE in patients with inoperable hepatocellular carcinoma allows with minimal invasiveness to reduce or stabilize tumor growth in 89.3 % of cases. Repeated performance of the procedure allows to increase the treatment efficiency by 21.2 %.
Supporting sustainable development goals and the challenge of reusing of the single use instruments in interventional radiology
Authors: Vyval M.B. , Shchehlov D.V. , Chebanyuk S.V.
Published: February 2022

Interventional radiology has traditionally been at the forefront of the modern medicine, offering minimally invasive alternatives to surgical treatment with reducing of the length of hospital stay. The problem of medical waste and the recycling of medical supplies to support sustainable development goals in the health sector has entred a “green revolution” that aims to overcome global warming and fight with environmental pollution. Operating waste accounts for 20 to 70 % of all hospital waste, and many of them require special disposal. On the other hand, revenues for health care companies continue to rise, as do patient care costs, which are a huge burden for families and health systems, especially in low-income countries during COVID-19 pandemic. The issue of disposal and reuse of unique, expensive disposable radiological profile instruments is not widely reported in the scientific literature, but surveys among interventionists indicate that reuse exists even in countries where it is officially prohibited. Despite the emergence of regulations on the reuse of disposable instruments, it is largely carried out outside the quality standards. Also, manufacturers are not interested in reusing disposable instruments and often refuse to provide information on how they can be properly recycled and sterilized. Although well-remanufactured tools have significant promise, both for reducing healthcare costs and environmental pollution, and for spreading modern interventional technologies to the critical places where resources are limited and they can save lives.
ДОСЛІДЖЕННЯ РОБОТИ СИСТЕМ АВТОМАТИЧНОГО КЕРУВАННЯ ЕЛЕКТРОПРИВОДАМИ КОНТАКТНИХ ЕЛЕКТРОВОЗІВ РУДНИХ ШАХТ
Authors: Yermilova N. , Kyslytsia S. , Zakharchenko R.
Published: February 2022

У статті розглядаються підходи до створення систем керування електроприводами тягового транспорту рудних шахт. Проведений аналіз роботи в різних режимах та порівняння характеристик чотирьох найбільш популярних типів електроприводів, що застосовуються у тягових електромеханічних системах, виявлені їх переваги та недоліки. Для підвищення ефективності тягових установок в якості приводних двигунів запропоновано використовувати синхронні двигуни з постійними магнітами, що нівелюють недоліки двигунів постійного та змінного струму, які здебільшого використовуються в електроприводах цих електровозів. З метою вдосконалення методів та схем автоматичного керування тяговими приводами розроблені математичні моделі динаміки руху тягової установки з синхронними двигунами з постійними магнітами (СДПМ), на базі яких створені комп’ютерні імітаційні моделі систем автоматичного керування (САК) для різних варіантів конструктивного виконання електродвигунів. За допомогою цих моделей проведений аналіз режимів роботи запропонованих САК тягових установок з СДПМ як без пускових обмоток, так і з ними. Порівнювалася робота САК для моделі тягової установки з лінійними регуляторами струму та швидкості, а також для моделі САК з оптимальними релейними сигналами керування, заснованими на використанні властивостей функцій перемикання оптимальних керуючих діянь. Аналіз ефекту від застосування запропонованих оптимальних релейних сигналів керування тяговою установкою показав, що при застосуванні САК з оптимальними релейними регуляторами тривалість перехідного процесу у випадку двигунів без пускових обмоток виявилась на 14% меншою в порівнянні з САК із лінійними регуляторами, а у випадку двигунів із пусковими обмотками - на 13.5% меншою, що доводить перевагу використання систем керування з оптимальними релейними регуляторами. Крім того виявлено, що такі системи автоматичного керування електроприводами тягових установок володіють астатизмом відносно моменту навантаження.
МЕТОДИ ВИКОРИСТАННЯ SIMD ІНСТРУКЦІЙ НА X86 СУМІСНИХ ПРОЦЕСОРАХ СТАРШОГО ПОКОЛІННЯ
Authors: Yanko A. , Martynenko A. , But O.
Published: February 2022

Розглянуто використання векторних SIMD інструкцій на x86 сумісних процесорах для покращення ефективності обчислення та обробки даних. Застосування векторного набору інструкцій дозволяє збільшити кількість операцій виконуваних за такт, при цьому зменшення розгалужень у алгоритмах позитивно влипає на швидкість виконання програми за рахунок меншого навантаження на модуль передбачення умовних переходів у процесорі. До цього часу існує програмне забезпечення, що виконується на x86 архітектурі процесорних ядер, даний факт не завжди дає змогу використовувати новітні векторні інструкції починаючи з SSE4.1. Головним недоліком попередніх реалізацій векторних наборів інструкцій – це відсутність логічних і арифметичних операцій з деякими типами даних, особливо це спостерігається у операціях з цілими числами. Використання особливості бінарної реалізації цілих чисел зі знаком і без знаку, дозволяє компенсувати відсутність логічних операцій для цих типів даних. Експлуатація вироджених та непрямих властивостей деяких інструкцій допомагає, як компенсувати відсутність арифметичних операцій з необхідними типами даних або операцій для цілих чисел іншої розрядності, так і оптимізувати виконання математичних операцій таких, як знаходження суми, різниці, множення та скалярного добутку. арифметична операція, векторна інструкція, набір інструкцій процесора, операнд константи, оптимізація процесу обробки даних, паралелізм на рівні інструкцій, паралельне обчислення.
ONE METHOD FOR ESTIMATION AUDIENCE OVERLAP IN SOCIAL MEDIA
Authors: Ivohin E. , Gavrilenko V. , Vavryk P.
Published: February 2022

In this paper we provided the definition of the Audience overlap network, as well as proposed a simple algorithm to compute overlap between two users on social media based on public data about their followers. There was proposed an alternative approach for computing overlaps based only on public data about users. This approach allows to include content overlap and activity patterns signals to be incorporated into more general statistical models featuring other covariates such as influencers’ direct engagement in shared conversations; relative influencer sizes and histories and links to similar third-party content to recover otherwise censored network structures and properties. For validate results there was designed a calibration process which utilizes Evolution Strategies algorithm to find a set of conditions which will make Audience overlap network built using similarity measures structurally equivalent to the Audience overlap network build on full information about followers.
SYSTEMATIC APPROACH APPLICATION TO THE DEVELOPMENT FOR THE SITE OF UNIVERSITY SCIENTIFIC ACTIVITY
Authors: Kapiton A. , Diachenko O. , Zakharov R. , Yanchuk T.
Published: February 2022

The article analyzes a systematic approach to accounting for scientific activities of universities The object of research of the work is chosen to take into account the research activities of teachers of higher education. The subject of the study is the analysis and use of tools for site development on the subject of this problem. The purpose of the authors consider the research, development and implementation of the site of accounting for research activities of teachers of higher education. It is proved that system analysis is based on systemology, principles of cybernetics and modeling and plays the role of a system approach tool based on mathematical analysis and probability theory, discrete mathematics and operations research, which uses modern computer technologies to implement its basic methods and solution’s application of applied problems.
МЕТОДИКИ ДІАГНОСТУВАННЯ ДЖЕРЕЛ ЕЛЕКТРОЖИВЛЕННЯ ПОРТАТИВНИХ РАДІОСТАНЦІЙ MOTOROLA
Authors: Yarovyi Vitalii , Radzivilov Grygoriy , Borysenko Maksim , Kutsenko Volodymyr
Published: February 2022

У зв’язку з постачанням до України портативних радіостанцій закордонного виробництва на новій елементній базі та внаслідок розвитку вітчизняного й неоригінального виробництва джерел живлення до них виникає необхідність в проведенні контролю їх технічних характеристик на відповідність їх показників джерелам живлення оригінального виробництва. У статті на основі раніше проведених досліджень вперше висвітлено питання щодо діагностування джерел живлення портативних радіостанцій транкінгового зв’язку виробництва компанії Motorola та акумуляторних батарей неоригінального виробництва за технологією компанії Motorola на предмет відповідності заявленим технічним характеристикам, запропоновані методики перевірки характеристик акумуляторів, досліджені можливості тестування акумуляторів за допомогою спеціального програмного забезпечення, запропоновано перевірки можливості визначення дати виготовлення складових акумуляторів до портативних радіостанцій Motorola (вбудованих літій-іонних акумуляторних елементів).
Evaluation of the portio vaginalis of the cervix by B-mode and colour Doppler ultrasound in Simmental cattle
Authors: Risvanli Ali , Safak Tarik , Yilmaz Oznur , Yuksel Burak , Kilinc Mehmet Akif , Seker Ibrahim
Published: February 2022

This study was aimed to reveal the relationship between the B-mode and colour Doppler ultrasonography features of the portio vaginalis of the cervix in Simmental cattle with different physiological and pathological conditions of genital organs. For this purpose, 90 cattle were used in the study. The length, width and circumference of the portio vaginalis of the cervix were measured ultrasonographically using a 5 MHz linear probe. In addition, the portio vaginalis of the cervix was ultrasonographically evaluated in terms of echogenicity, cystic formations, calcification and integrity of its borders. Regarding the colour Doppler ultrasonography, measurements of the vascular distribution category, vascular density and the vascular morphological appearance were made. In this study, it was found that the rate of irregularity of the border of the portio vaginalis in B-mode ultrasonography according to the pregnancy status was 10.9% in non-pregnant cows, while this was not observed in pregnant cows (0.0%). According to the metritis status, it was observed that the rate of regularity of the border of the portio vaginalis was higher in animals with metritis (45.5%) in B-mode ultrasonography. As a result, it was concluded that there were significant changes in the B-mode and colour Doppler ultrasonography characteristics of the portio vaginalis of the cervix in different physiological and pathological conditions in cattle, and that hypotheses can be developed regarding the fertility of the animals by evaluating these characteristics.
Slanted slot was the most resistant to failure of ventral slot techniques tested in rabbit cervical vertebrae
Authors: McCartney William , Ober Ciprian , Benito Maria J. , Mac Donald Brian
Published: February 2022

The ventral slot technique is used to relieve neural compression secondary to intervertebral disc degeneration or disease. In the present study, the biomechanical properties of three different ventral surgical procedures in the rabbit C6–C7 vertebral motion unit (VMU) were assessed and compared with the intact C6–C7 VMU. The ventral slot procedure (slanted, full, or mini; n = 8/group) was performed on these cervical vertebrae. Normal spine torsion and flexion values were compared to those of spines subjected to slanted, full, and mini slot surgery. The slanted slot spines were the most stable, maintaining 70% of normal cervical spine strength, compared to 26% with the full slot and 30% with the mini slot. Regarding torsion, slanted slot spines showed 74% stability compared to the normal cervical spine, while the full slot and mini slot spines showed 58% and 62% stability, respectively. Flexion values were lower after all versions of the ventral slot procedure than in the normal spine, with the greatest flexion difference occurring after the full slot procedure (21% of the normal flexion value). The flexion values also differed significantly between the slanted and full spine groups, and all operated spines showing roughly 60% torsion rates compared with normal spines. The slanted slot maintains more stability in rabbit cervical spine than the other procedures. To our knowledge, this was the first study to examine biomechanical failure differences between the distinct versions of this ventral slot procedure.
Quantitative and qualitative properties of giblets from conventional, organic, and wild ducks
Authors: Abdullah Fouad Ali Abdullah , Buchtová Hana
Published: February 2022

The aim of the study was to evaluate selected properties of giblets (liver, heart, and gizzard) from conventional (C), organic (O), and wild (W) ducks. A total of 24 giblets (24 of each organ) were analysed in each bird group. Production properties, colour indicators, haem pigment content and chemical composition were compared. The heaviest organ with the highest yield was the liver in C and W ducks and the gizzard in O ducks (P < 0.05). The liver and gizzard of W and O ducks were darker (P < 0.05) compared to the same organs in C ducks. The redness of the heart of O ducks was higher (P < 0.05) than that of the heart of both other groups of ducks (C and W). All W duck organs contained (P < 0.05) more haem pigment. The livers of reared ducks (C and O) contained more protein (P < 0.05) than the livers of W birds. The liver of C reared poultry was about 3–4 × fattier (P < 0.05) compared to the liver of the remaining two groups of ducks. The heart of wild ducks had the highest protein and lowest fat content, the heart of ducks from the C breeding system had the least protein, whereas ducks bred organically had the highest amount of fat in the heart. Ducks from the O system had a fattier gizzard compared to other birds (P < 0.05). The highest protein percentages were found in the gizzards of W ducks, the smallest in the gizzards of C poultry.
Kontribusi Dukungan Orangtua Dan Peran Teman Sebaya Terhadap Sikap Remaja Putri Dalam Menghadapi Masa Pubertas Serta implikasinya Dalam Bimbingan Dan Konseling
Authors: Dela Vitria Larseman , Syahniar Syahniar , Solfema Solfema
Published: February 2022

This study aimed to describe: parental support and the role of peer, the attitude of the young women in facing the puberty, the contribution of parental support and the role of peer on attitudes young women in facing the puberty. This study includes a quantitative study, with descriptive correlational approach. The population of this study was students of SMPN 1 Batang Anai. The sample was selected by using purposive random sampling. The findings of the study are: (1) the level of parental support and the role of peers on average at the high category, (3) the attitude of the young women in facing the puberty are in a category receive, (4) there is a contribution of parental support and role of peers by 24.6% and 31.5%,  and (6) there is a contribution between parental support and the role of friend peer by 38.4%.
Identification of Missing Eastern Cultural Values During the Covid 19 Pandemic in Early Childhood Learning
Authors: Pamungkas Joko
Published: February 2022

The purpose of this study was to identify Eastern Cultural Values Lost During the Covid 19 Period in Early Childhood Learning. The research method used is a survey. The subject of this research is a kindergarten institution. The data collection technique uses a questionnaire containing what values have been lost during this pandemicThe results of this study are that this pandemic has an impact on the education sector. Learning that used to be face-to-face is now online learning. This has an impact on the loss of missing eastern cultural values, including shaking hands, sitting side by side, recreation together, holding hands, kissing hands, embracing, performing arts, ceremonies, eating together, extra art learning, field trips, gymnastics together, smiling. who bloomed, and in uniform.
Analisis komoditas unggulan sektor pertanian
Authors: Faqih Achmad
Published: February 2022

One of the steps to inventory/identify regional economic potential is to identify potential, mainstay and superior products of the region in each sub-sector. This research was conducted to find out what commodities are the leading sectors of agriculture in Indramayu Regency as well as changes and shifts in the basic commodities of the agricultural sector in Indramayu Regency. This study uses quantitative descriptive research methods. The research sample consisted of 31 districts. The object of this research is data on the development of agricultural commodities in the Department of Agriculture, Indramayu Regency. The data used in this study is secondary data, namely data on agricultural sector commodity production in Indramayu Regency during the 2015-2019 period. The results showed that: the main commodities of Indramayu Regency in its sub-sector were food crops, namely superior rice in 28 sub-districts, superior green beans in nine districts, peanuts, cassava and sweet potatoes. In four sub-districts, maize and soybeans are superior in three sub-districts, besides that the growth of rice, mango, jackfruit and papaya commodities in Indramayu Regency is included in the advanced or progressive group because of its positive value.
Disparitas perkotaan-pedesaan: pemerataan dalam akses layanan kesehatan primer untuk lansia selama pandemi Covid-19
Authors: Noor Zumrotin Azizatun , Sekarningrum Tiara Dewi , Sulistyaningsih Tri
Published: February 2022

Penelitian ini bertujuan untuk menggali dan menganalisis pemerataan layanan kesehatan primer lansia saat pandemi untuk mengevaluasi kinerja sistem perawatan kesehatan yang ada di Malang. Melalui penelitian dengan metode studi pustaka. Pengumpulan data berasal dari buku teks, jurnal, artikel ilmiah, tinjauan pustaka yang memuat konsep-konsep yang dipelajari.Hasil menunjukkan Pada Kabupaten Malang, lansia perkotaan cenderung mudah dalam mendapatkan akses kesehatan berbeda dengan lansia pedesaan yang cenderung susah dikarenakan beberapa faktor seperti tinggal di derah pelosok. Hal terbukti dengan dilakukannya vaksinasi door to door oleh pemerintah Kabupaten Malang untuk menjangkau daerah yang sulit agar terciptanya pemerataan pelayanan kesehatan. Pemerataan di Kabupaten Malang cukup baik beriringan dengan kualitas kinerja perawatan kesehatan. Dengan vaksinasi door to door pemerintah melakukan percepatan vaksinasi agar terciptanya pemerataan.
Pedagogical competency development of prospective special education teachers through based learning models project
Authors: Yuwono Imam , Rapisa Dewi Ratih
Published: February 2022

Learning in elementary schools is presented thematically by combining several subjects in a theme. In special schools and inclusive schools, teachers with special education backgrounds have an important role in simplifying the subject matter by adjusting the results of each child's assessment, one of which is science material. Support for learning services for special needs children requires various preparations from various parties such as educators so that skills in preparing materials, determining approaches, models, methods, and learning media become a pedagogical competency that must be mastered by prospective special education teacher students. This study aims to describe the implementation of the Project Based Learning model which consists of stages of planning, implementation, evaluation and presentation to build the pedagogical competence of students of the Special Education Study Program as prospective teachers in teaching science material to Children with Special Needs. This research was conducted using a qualitative approach with the type of case study. The results showed that lectures with project-based learning models through the stages of planning, implementation, presentation and evaluation were able to build student pedagogical competence in terms of special needs children's assessment, learning assessment, lesson plans modification, making science learning media, role-playing lesson plans modification, and implementing lesson plans that has been prepared in order to prepare special education students to become professional teacher candidates.
Three-dimensional 3D-bioprinting: the basis of technology and its application in the interests of biology and medicine
Authors: Volotovski I. D. , Pinchuk S. V.
Published: February 2022

This review is devoted to one of the actual problem of modern biology and medicine, we are witnessing. The text provides information on 3D printing method, equipment that is used to manufacture of three-dimensional bioproducts and the nature of the consumable materials - bioinks, fillers and cells which during printing transform into three-dimensional bioproduct characterized by vitality and expression of specific marker factors of corresponding tissues and organs. Special emphasis in this review is made on prospects of use of stem cells which are along with a variety of cells of tissues and organs have found application in bioprinting. Three methods of bioprinting: inkjet, extrusion and laser are described. Advantages and disadvantages of each method are discussed. Bioinks, their properties applicability to various printing technologies and strategy selection of bioink and cell composition defining viability of three-dimensional structures and possibility of their application in clinical praxis are detailly described. Short list of achievements in the field of bioprinting of various organism tissues and the characteristics of the bioproducts obtained are given. Significant progress and promising research in the field of 3D bioprinting are marked.
Proteomic analysis of Pseudomonas chlororaphis subsp. aurantiacа strains capable of phenasine compounds overproduction
Authors: Verameyenka K. G. , Shapira M. A. , Naumouskaya V. A. , Ashmankevich D. D. , Maximova N. P.
Published: February 2022

Proteomic analysis is a highly effective method for bacteria identification and the elucidation of protein's content in prokaryotic cells at different growth conditions. To our knowledge this approach is hardly ever used for characterization of producers of biologically active substances. The understanding of the changes in protein profile in mutant strains capable of biologically active substances overproduction helps to recognize the biochemical and molecular basis of metabolic changes which lead to overproduction. So that, proteomic analysis could be especially useful for optimization the producer's creation techniques.

The purpose of current research was to carry out proteomic profiling of bacteria P. chlororaphis subsp. aurantiaca mutant strains capable of overproduction of phenazine antibiotics. Microbiological and biochemical methods were used for these aims.

In current research a proteomic analysis of strains of P. chlororaphis subsp. aurantiaca producing phenazines was carried out. An early (during log-phase) onset of expression of individual genes of phz-operon which codes enzymes for phenazines synthesis was demonstrated. It was also found that the wild type strain has the highest level of PhzO protein. The gene encoding this protein is located outside the phz-operon. We weren't able to establish the correlation among PhzO protein content and concentration of the derivatives for which appearance PhzO is responsible. A general tendency of producer strains towards the accumulation of enzymes and proteins of the antioxidant defense system was revealed. Producer strains also demonstrate a significant increase in the concentration of proteins involved in DNA repair as well as chaperones involved in the native protein conformation maintenance.
World market of potatoes and potato products and Belarus’s place in it
Authors: Karpovich N. V. , Makutsenya E. P.
Published: February 2022

The article provides a comprehensive analysis of the world market for potatoes and potato products. A comparative assessment of world production and trade in terms of commodity and geographic focus is given. Key world players in the potato and processed potato market are presented. The place of the Republic of Belarus in the world commodity flows of potatoes and potato products in commodity, country and price aspects has been determined.
Administrative and delict policy of the Republic of Belarus: trends, achievements, increasing the efficiency of realization
Authors: Ladutko V. K.
Published: February 2022

This article discusses the main trends, achievements and problems of forming and implementing the administrative and delict policy of the Republic of Belarus as a strategy of governing the state to ensure law and order, combating administrative offenses in various spheres of public relations. The modern tasks of the state predetermine the transformation and new trends in the development of administrative and delict policy of the state. The most striking manifestation of these changes is the reform of the law on administrative offences. The main innovations of the law on administrative offences, provided for as a result of its reform, are presented. In order to improve the efficiency of the formation and implementation of administrative and delicate policies, the need for legal forecasting tools for the consequences of new prohibitions and measures of administrative and legal coercion is justified. A system of indicators has been developed to conduct a full cycle of assessment of the regulatory impact of administrative law. The expansion of the subjects and facilities for assessing the regulatory impact of regulations in the application of administrative and legal coercion measures is justified.
The road to the symbolic and metaphorical space of the works of Y. Kolas: comparative point of view
Authors: Shaladonava Zh. S.
Published: February 2022

The symbolic and metaphorical fullness of the image of the road in the poem of Y. Kolas “New Land” in comparison with the works of N. Gogol and T. Shevchenko is revealed in the article. It is emphasized that in the artistic and philosophical understanding of the authors, the road is presented as a way of heroes’ existence, overcoming life obstacles, as well as a universal symbol of the endless movement of spirit, thought, comprehension of existential values. Comparative analysis made it possible to expand the range of semantic meanings of the image as an embodiment of the search for spiritual, national and historical self-identification of a person, people, country.
Suitable and Available Land for Settlement Development in Cianjur Regency
Authors: Tanjung Nurul Amaliyah , Ernan Rustiadi , Widiatmaka
Published: February 2022

A merging of Jakarta and Bandung metropolitans influence the development of the areas around them. Consequently, people are migrating to the cities caused an increasing population. It leads to experiencing uncontrolled advancement and arising problems. One of them is the raising land demand for settlement development, but the land is limited. Therefore, there is a need to address these particularities. This research aimed to model suitable and available land for settlement development in Cianjur Regency. Multi-criteria evaluation (MCE) and geographical information system (GIS) were collaborated to define the suitability criteria. The analytical hierarchy process (AHP) was employed to set the criteria's weight. Spatial Plan and LP2B were carried out as limiting factors. The result showed that the most crucial consideration came from the disaster. The suitability classes in Cianjur regency are: highly suitable 36%, Suitable 7%, Marginally suitable 44%, and Not suitable 14%. 85% of land in 2018 was available for settlement. Yet it is decreasing becomes 2% in 2030. Therefore, the potential land for settlement development is The different perspectives among developers, academics, and government in determining the most critical criteria for land suitability plays a crucial role in the next Cianjur’s settlement development planning. The implementation of the Spatial Plan can minimize environmental problems such as land conversion. In addition, regarding the new regulation on LP2B, the Spatial Plan has to be updated to synchronize the plan between Spatial Plan and LP2B.
Forest and Peatland Fire Severity Assessment at Siak Regency, Riau Province using Sentinel-2 Imagery
Authors: Afina Fakhri Sukma , Syaufina Lailan , Sitanggang Imas Sukaesih
Published: February 2022

Siak Regency, Riau Province is one of the most forest and land fire-prone regencies in Indonesia. Most of the fires occur in peatland areas which contributes to the transboundary haze pollution in the region. Despite limited studies, fire severity assessment is an essential step in post-fire activities to estimate ecological impacts and economic impacts and law enforcement.  This study aims to estimate fire severity using Sentinel-2 imagery at Siak Regency, Riau Province. The methods applied Normalized Burn Ratio on Sentinel-2 Imagery as an identification model based on reflectance value for 2019 imagery. The study revealed that burned areas in Siak Regency could be classified into four fire severity classes: low fire severity, moderate-low fire severity, moderate-high fire severity, and high fire severity. High fire severity was found mainly at Sungai Apit and Mempura Districts.
Stakeholder Participation of Painted Terrapin Conservation in District Aceh Tamiang
Authors: Hernawan Endang , Basuni Sambas , Masy'ud Burhanuddin , Kusrini Mirza Dikari
Published: February 2022

Painted Terrapin (Batagur borneoensis Schlegel and Muller 1845) conservation in the coastal area of Aceh Tamiang Regency faces difficulties because it involves many stakeholder. The objective of this study were to analyze stakeholder interest, influences and describe the relationship among stakeholder in the conservation of Batagur borneoensis at Aceh Tamiang District. The study was conducted in Aceh Tamiang District and respondents were selected using purposive sampling method. The data obtained using questionnaire, interview, and direct observation were analyzed with stakeholder clasification matrix, stakeholder interaction matrix and descriptive analysis. The results showed that there are twenty-seven stakeholder involved in the conservation of Batagur borneoensis which can be categorized as subjects, key players, context setters, and crowds. To achieve the management objectives of Batagur borneoensis conservation, stakeholder engagement needs to be improved through collaboration among key players, participation all key stakeholder, and community empowerment. Keywords: Batagur borneoensis, collaboration, conservation, stakeholder analysis
Mangrove Diversity in Production Forest Management Unit (FMU) Bulungan Unit VIII North Kalimantan
Authors: Kartika Karlina Fitri , Istomo Istomo , Amanah Siti
Published: February 2022

Mangrove ecosystem have various important roles as habitat for marine and terrestrial species. However, the ecosystem has recently faced anthropogenic threats delivered by the expansion of aquaculture pond. Study of mangrove diversity was conducted in Production FMU Bulungan Unit VIII, North Kalimantan. The study was aimed to analyze species diversity in the FMU Bulungan Unit VIII and determine community perception on existing mangrove condition. Vegetation analysis was applied to quantify mangrove community in two sampling locations, Salimbatu and Liagu, within 26 quadratic plots (10mx10m). As many as 63 respondents were interviewed to analyze communities’ perception. As the result, 10 species were identified species and one unidentified species recorded during the survey. Rhizophoraceae was dominated the species composition in sampling area. Rhizophora mucronata had the highest Importance Value Index in tree and seedling stage while Rhizophora apiculata was dominant in sapling stage. On the other hand, Bruguiera parviflora was recorded on each growth stages in all sampling plots. Species diversity index (H’) of mangrove vegetation in the FMU was found at 1,68 with species richness index value 1,58. This diversity index considered as moderate diverse since only few vegetation species are able to live in the mangal. The perpendicular structure of mangrove in the FMU formed an inverse J-shape which showed normal growth of uneven-age forest stand. The interview result implied that more than 50% of the respondent considered that mangrove condition in their village area has been disturbed. Therefore mangrove management with local community involvement is neccessarily required to improve the mangrove performance. Keywords: communities perception, habitat, mangrove, species diversity
CUTANEOUS AND BONE METASTASIS OF OCCULT BREAST CANCER: CASE REPORT
Authors: Costa Rafael Everton Assunção Ribeiro da , Oliveira Fergus Tomás Rocha de , Siqueira Eduarda Norberto , Araújo Ana Lúcia Nascimento , Vieira Sabas Carlos
Published: February 2022

Introduction: Occult breast cancer (OBC) is defined as a metastatic carcinoma that occurs mainly in the axillary lymph nodes, derived from a primary malignant breast tumor undetectable by clinical and radiological analyses. OBC is a rare disease accounting for 0.3%–1.0% of all breast cancers, which occurs more commonly at the age of around 55 years. The OBC represents a rare event (especially with the manifestation of systemic metastases) and a major diagnostic challenge. Thus, the aim of this study was to report a case of OBC with the primary manifestation of cutaneous metastases and the subsequent detection of bone metastasis. Case report: A 70-year-old female patient, G1P0A0, nonsmoker, nonalcoholic, with hypertension, and sedentary lifestyle, exhibited multiple metastatic cutaneous lesions in the left cervical region (2 cm), of the left breast (3 cm), left axilla (0.5 cm), left subscapular region (3 cm), and in the second and fifth left chirodactyls (using anastrozole for 1 month). Mammography, ultrasonography, and magnetic resonance imaging of the breast were performed, and no structural alterations were detected in any of these tests. Biopsy of the skin lesion of the left cervical region and immunohistochemistry also indicated positive estrogen receptors (ER), progesterone receptors (PR), and GATA-binding protein 3 (GATA-3; compatible with breast cancer metastasis), establishing the diagnosis of occult breast cancer with cutaneous metastasis. The use of anastrozole was maintained. The scintigraphy was performed, indicating bone metastasis in the right coastal arcs 8 and 9 considered stable in a new test performed 8 months later. All cutaneous metastatic lesions disappeared 2 years later, with the exception of a lesion in the left cervical region, where surgical resection was indicated. The study was approved by a Research Ethics Committee, under CAAE No 30154720.0.0000.5209. Conclusion: The patient exhibited an excellent response to anastrozole and is in excellent general condition with the stability of bone metastasis.
EPIDEMIOLOGICAL RELATIONSHIP BETWEEN HORMONE REPLACEMENT THERAPY AND BREAST CANCER
Authors: Vieira Amanda Cristina de Souza , Vasconcelos Antônio Pedro Oliveira de , Araujo Jaqueline Maria Pinheiro de , Müller Juliana Comin , Magalhães Larissa de Cassia Afonso , Silva Renato Duarte da , Vieira Ricardo Baroni , Anjos Fabiana Candida de Queiroz Santos
Published: February 2022

Objective: The aim of this study was to epidemiologically analyze the hormone replacement therapy (HRT) and the emergence of breast cancer. Methodology: This is an article review from the databases such as LILACS, SciELO, Bireme, and Medscape, utilizing the keywords: menopause, HRT, breast cancer and complications, employing the use of connectors when necessary. This review aims to elucidate what has been published in the last years about the usage of hormone therapy and the emergence of breast cancer since there are disagreements between the literature. Results: The analysis displayed positive effects during the usage of HRT, such as maintenance of bone density, prevention of fractures, and cardiovascular events in patients with no previous changes in this system, and also showed us a strong relationship between HRT and the incidence of breast cancer in menopausal women with a focus into the imposing time of use ratio. Meanwhile, this development risk of breast CA can be reduced in the long run with the withdrawal of the previously initiated therapy. The progesterone HRT has been shown to have lower risks in association with estrogen than when compared with the association of synthetic progestins and estrogen. Associations have similar results for oral and skin HRT. In patients using the postmenopausal hormone therapy, the risk of mortality from breast cancer was reduced in patients with exposure for a maximum of 5 years, more than 5–10 years, or more than 10 years. Conclusion: In view of the exposure, it is considered that the HRT is more beneficial than malefic to the life and health of women. Meanwhile, the risk of breast CA goes up while the HRT time stretches over the years. Thus, it is necessary to individually evaluate the benefits and risks to better identify the therapy that should be utilized.
BREAST CANCER IN YOUNG PATIENTS: PROGNOSTIC AND PROFILE EPIDEMIOLOGICAL ANALYSIS IN A TERTIARY HOSPITAL
Authors: Assis Amilcar Alves , Passos Mauro , Kouzak Rodrigo , Evangelista Karoline , Caldas Natasha
Published: February 2022

Breast cancer is the second most prevalent and first in mortality in Brazilian women. Its incidence has increased in recent years in all age groups. According to the Instituto Nacional do Câncer in 2019, 59,700 new cases of breast cancer are expected, with an estimated risk of 56.33 cases per 100 women. The diagnosis of breast cancer is more frequent in women after 50 years of age; it is estimated that only 25% of all cases occur in women below the age of 50 years; however, there was a literature consensus that tumors in this young age group have a worse prognosis, both because they are biologically more aggressive and because of affect women outside the screening age group in Brazil; thus, the rate of locally advanced disease at diagnosis in this age group is considerably higher. It is suggested that early onset breast cancer is related to different etiological factors, histopathological aspects, and clinical outcomes, as compared to postmenopausal breast cancer. Thus, age becomes an important prognostic factor. Since breast cancer is a curable pathology, the type of therapeutic approach also varies, with proposed treatment tends to be more aggressive. With the advent and increasing availability of genetic tests, predisposition of breast cancer has increased the number of indications for prophylactic mastectomies, especially in younger age groups or notably in patients with known pathological mutations in BRCA1 and BRCA2 genes. However, the literature is still controversial regarding its impact on overall survival. Breast cancer diagnosed before the age of 50 years is a behavioral disease, with prognosis and approach very different from that diagnosed in postmenopausal women. Therefore, it is important to know the profile of these patients to provide optimal treatment and achieve the best outcomes.
FAT GRAFTING AFTER RADIOTHERAPY AND BREAST IMPLANT
Authors: Sousa Paulo Roberto Moura de , Resende Mauricio de Aquino , Joioso Ailton , Bonfim Raimundo Jovita Araujo , Breda Carlos Eduardo Witoslawski
Published: February 2022

This is a case report of reconstruction of the right breast and aesthetic improvement of the left breast, in a 52-year-old smoker woman, with bilateral breast cancer, neoadjuvant chemotherapy, modified radical mastectomy on the right, quadrantectomy with left, lymphadenectomy, and radiotherapy (RT). She sought the Amaral Carvalho Hospital for reconstructive surgery after 6 years of treatment. She underwent fat grafting (FG) with 237 mL on the right breast and 90 mL on the left breast and correction of the left areola. After 6 months, a retromuscular tissue expander was placed on the right, and remodeling of the breast and correction of the surgical scar are done on the left. After 8 months of achieving expansion with 350 mL of saline solution, the tissue expander was replaced by a wide base anatomical prosthesis with 485 mL and a 225 mL nonanatomical round prosthesis additive to the left. RT makes breast reconstruction difficult, as it gives better results with myocutaneous flaps. FG has a regenerative effect on irradiated tissues. Historically, reconstruction with autologous tissue is preferable to reconstruction with implantation in patients irradiated after mastectomy, as it presents less reoperation (16.6% vs. 37.0%, p<0.0001), total complications (30.9% vs. 41.3%, p <0.0001), and reconstructive failure (1.6% vs. 16.8%, p<0.0001). Radiodermite affects more than 90% of patients treated with RT. The dermis is affected with an increase in fibrosis, reduction in the number of capillaries, and irregular distribution. FG is able to reverse these changes. FG improves the characteristics of irradiated tissue, restores elasticity, and allows breast reconstruction with an implant without a myocutaneous flap.