bluuebunny/crossref_metadata_2025 huggingface dataset:
Sistem Pendidikan Pondok Pesantren Dalam Pembinaan Kualitas Santri
Authors: Qurtubi Moh , Hudi Saman
Published: April 2022

Pondok Pesantren pada dasarnya tidak menggunakan batasan umur jangka waktu pendidikan. Dengan demikian sesungguhnya Pondok Pesantren merupakan pendidikan seumur hidup atau life long education. Yang artinya seluruh anggota masyarakat boleh menjadi santri untuk selamanya jika ia menghendaki. Atau sewaktu-waktu pindah untuk mencari guru di Pondok Pesantren lain atau pulang ketempat asal bila telah merasa cukup dan mampu mengembangkan diri sendiri. Sekalipun demikian prinsip tersebut dikemudian hari tidak mutlak berlaku seluruhnya, sebab terdorong oleh kesadaran pentingnya daya guna dan hasil guna pendidikan, maka lambat laun dibentuklah madrasah dalam lingkup Pondok Pesantren yang mengenal batas-batas waktu dan jenjang pendidikan. Hal ini jelas memposisikan pendidikan agama sebagai salah satu muatan wajib dalam kurikulum pendidikan apapun. Disamping itu diakui secara jelas bahwa, yang menjadi persoalan bagaimana pendidikan Islam itu sendiri menempatkan dirinya pada posisi yang tepat dan strategis sehingga dapat mewujudkan eksistensinya. Keberadaan Pondok Pesantren sebagai lembaga pendidikan Islam tradisional di Indonesia, khususnya di pulau Jawa, sudah cukup lama dikenal oleh masyarakat sejak 500 tahun yang silam, yakni ketika Syekh Malik Ibrahim memperkenalkan Pondok Pesantren pertama kalinya di Gresik. Namuin demikian Pondok Pesantren sebagai lembaga pendidikan, masih belum banyak diketahui masyarakat secara mendalam, meski ia telah tumbuh cukup lama ditengah-tengah msyarakat Indonesia.

Kata Kunci : Sistem Pendidikan, Pondok Pesantren, Pembinaan, Kualitas Santri
Strategi Remedial Teaching Guru Pendidikan Agama Islam Terhadap Siswa di Masa Covid 19 di Sekolah MI Riyadut Tholibin
Authors: Jasuli Abdullah Hasbi,
Published: April 2022

Guru adalah salah satu komponen penting dalam pendidikan yang wajib bertanggung jawab atas terselenggaranya proses pembelajaran. Dengan peran dan tanggung jawab guru tersebut diharapkan tidak terjadi kesulitan dalam pembelajara. Namun bila terjadi kesulitan dalam pembelajaran diharapkan guru membuat strategi yang baik sehingga kesulitan belajar yang dialami siswa dapat diselesaikan dengan baik. Setiap individu memang tidak ada yang sama, perbedaan individual inilah yang menyebabkan perbedaan tingkah laku belajar dikalangan peserta didik. Dalam keadaan peserta didik tidak dapat belajar sebagaimana mestinya, itulah yang disebut kesulitan belajar. Fokus penelitian ini yaitu Bagaimana strategi guru Pendidikan Agama Islam dalam pelaksanaan Remidial Teaching siswa MI Riyadut Thalibin di Masa Covid 19. Penelitian menggunakan prosedur penelitian kualitatif dengan pendekatan deskriptif karena penelitian ini bertujuan untuk menguraikan tentang sifat-sifat (karakteristik). Dalam penelitian ini memperoleh dua kesimpulan, yaitu kesimpulan umum dan khusus. Kesimpulan umum yaitu: Strategi Remedial Teaching Guru Pendidikan Agama Islam Terhadap Siswa di Masa Covid 19 di Sekolah MI Riyadut Tholibin dapat dikatakan baik. Dalam mengatasi kesulitan belajar siswa guru aktif dalam melakukan perbaikan, perbaikan tersebut bisa dilakukan dengan kerjasama antara pihak kepala sekolah, tenaga pendidik lain, waka kurikulum dan siswa. Sedangkan kesimpulan umum berisi : 1) mendiagnosis kesulitan belajar, dengan cara mengetahui jenis kesulitan belajar dan faktor-faktor yang mempengaruhinya, 2) menganalisis kesulitan belajar, dengan cara Menentukan bidang kecakapan tertentu yang dianggap bermasalah dan memerlukan perbaikan. 3) remedial teaching, dengan cara, menentukan tindakan yang harus di lakukan, bimbingan khusus, pengukuran kembali terhadap prestasi belajar peserta didik, dan kemudian dilakukan re-evaluasi dan re-diagnostik.

 Kata Kunci :  Strategi,  Remedial Teaching,  Guru PAI, Covid 19
Relationship between platelet parameters and disease severity and coagulpathy in covid 19
Authors: ERARSLAN Sertaş , PAŞALI KİLİT Türkan , ALKAN ÇEVİKER Sevil , GÜMÜŞÇÜ Hasan Hüseyin , AKINCI Mustafa , GÜLCAN Aynur
Published: April 2022

Objectives: Coagulopathy plays an important role in the clinical course of Covid-19 disease. The aim of our study is to examine the factors affecting the severity of this disease and to examine whether there is a relationship between platelet parameters and disease severity and coagulopathy markers.

Methods: The study was planned single-center, retrospective, and cross-sectional. 189 patients diagnosed with Covid-19 were admitted to the Internal Medicine Department. Patients were divided into 3 clinical categories according to the severity of the disease. The relationship between mean platelet volume and other platelet parameters, and disease severity and coagulopathy parameters were statistically analyzed.

Results: The study included 189 patients.182 of whom were discharged and 7 of whom died. The average age of the patients was 54.13 ± 14.21. D-Dimer levels were compared between the groups and were found to be significantly higher in cases of severe pneumonia. The group with severe pneumonia group had a higher PDW level than other groups. MPV was detected over 10 fl in the severe pneumonia group, but no statistically significant difference was found with the other groups. PT and INR levels are higher in patients with upper respiratory tract infection (URTI) compared to patients with mild to moderate pneumonia. APTT levels were found to be higher in patients with URTI than in patients with severe pneumonia.

Conclusion: In our study, PDW height and MPV height were determined from the findings showing platelet activation in patients with severe pneumonia. If an increase in these parameters is detected in patients diagnosed with the Covid 19 disease, close follow-up should be performed in terms of the development of complications.
Approach to the metastatic bone lesions; tumor investigation in a patient without cancer
Authors: UYAR Seyit , BOSTAN Feyzi
Published: April 2022

With the increase in the use of radiological imaging methods, the number of patients with a bone lesion (mostly in the form of a lytic lesion) or metastasis suspicion is also increasing. Patients with such a suspicious bone lesion are referred to internal medicine outpatient clinics for further investigation. However, there is no a standard approach for tumor investigation in incidental bone lesions in the literature. In this article, we mentioned about definition, clinical findings and diagnostic approach to these lesions.
Pro-environmental Behaviours and Protection Motivation Theory: A Case of Two Universities in Bandung, Indonesia
Authors:   Environmental Engineering Study Program, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung, May Annisa Ritka , Nastiti Anindrya ,   Environmental Management Technology Research Group, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung,   Center for Environmental Studies, Institut Teknologi Bandung
Published: April 2022

Abstract: Maladaptive behavior towards the environment can threaten environmental conditions and this requires a more in-depth analysis. Students as part of the younger generation have the responsibility as educators, planners, and policy makers on environmental issues for a sustainable future so that research on university students’ pro-environmental behavior is needed. This study adopted a developed causal model of pro-environmental behavior based on Protection Motivation Theory (PMT) in a sample of 363 Indonesian university students. This theory is expected to identify barriers and impulses in carrying out pro-environmental behavior. Based on the results, environmental attitude, self-efficacy, response costs, intrinsic and extrinsic rewards from maladaptive behavior to the environment, and perceived severity of respondents' have a direct and significant effect on pro-environmental behavior. In addition, perceived vulnerability has an indirect effect on pro-environmental behavior through the level of perceived severity. Improving pro-environmental behavior for students could be focused on environmental attitude and self-efficacy through environmental protection based on tested causal model. Keywords: pro-environmental behavior, protection motivation theory, environmental attitude, self-efficacy, perceived severity.
MANAJEMEN RISIKO PADA RENCANA PENGAMANAN AIR MINUM (RPAM) OPERATOR UNTUK SUMBER AIR PERMUKAAN PDAM KRUENG PEUSANGAN KABUPATEN BIREUEN
Authors:   Program Studi Teknik Lingkungan, Fakultas Teknik Sipil dan Lingkungan, Institut Teknologi, Sudrajat Arief ,   Program Studi Teknik Lingkungan, Fakultas Teknik Sipil dan Lingkungan, Institut Teknologi Bandung, Jl Ganesha 10 Bandung 40132, Nastiti Anindrya ,   Program Studi Teknik Lingkungan, Fakultas Teknik Sipil dan Lingkungan, Institut Teknologi Bandung, Jl Ganesha 10 Bandung 40132
Published: April 2022

Abstract. Perusahaan Daerah Air Minum (PDAM) Krueng Peusangan uses water from Krueng Peusangan as its source of raw water. Krueng Peusangan water quality monitoring was carried out by BAPEDAL Aceh in 2016 and the first period was classified into "good condition" and in the second period classified into "lightly polluted". This incident indicates that the quality of Krueng Peusangan water is very fluctuating and can change at any time. This is a challenge for PDAM Krueng Peusangan in achieving the quality of water that can meet the quality standards based on Permenkes No.492 of 2010 tentang Persyaratan Kualitas Air Minum. Risk management is a tool that can control all the risks contained in raw water sources to consumers through a process of identification, assessment, risk prioritization, and recommendation of improvement plans that can be achieved through a Water Safety Plan (RPAM) or commonly known as Rencana Pengamanan Air Minum (RPAM) operator. From the identification process, PDAM Krueng Peusangan has 17 hazard events that could cause a decrease quality of water processed by Teupin Mane WTP, BRR WTP, and WKE WTP. In general, these are caused by activities upstream of the river, dosing of coagulants and disinfectants, leakage of distribution pipes, and water quality testing that are not routinely carried out for certain parameters. To deal with the hazard events identified, 41 control measures are required. After being reviewed, there were 22 improvement plans to deal with the major theme of hazardous events. In addition, operational monitoring are also provided with Standard Operating Procedure (SOP), Work Instruction (IK), internal dan external communications, supporting programs, reviews and audit. Keywords: Hazard event, risk, quality, implementation, Water Safety Plan (WSP)
prevención cuaternaria en tiempos de pandemia
Authors: La Valle Ricardo Ángel , Gómez Aurelio , Báez Miguel Pizzanelli
Published: April 2022

La pandemia de COVID 19 ha provocado un cambio imprevisto en el mundo, ha dejado expuesta, como nunca, la inequidad, injusticia distributiva y las falacias de modelos económicos que han hegemonizado las últimas décadas. Al mismo tiempo se ha abierto una ventana de oportunidad para avanzar hacia cambios profundos de los sistemas sanitarios. Es en este marco que, desde la visión de la Prevención Cuaternaria, proponemos los principios rectores de lo que consideramos debe ser el cambio en el sistema de salud para que este cambio no sea más de lo mismo.

En Sudamérica tenemos una oportunidad única para este cometido, pero para ello debemos “desprendernos” de la colonialidad, debemos atrevernos a fundar un nuevo acuerdo social que privilegie la vida, las personas, una distribución más equitativa de la riqueza y dejar atrás el neoliberalismo, el racismo y el machismo que son parte constitutiva e inseparable del modelo actual.
Resistência antimicrobiana em uroculturas de moradores das Zonas Norte e Nordeste de Porto Alegre
Authors: Reolom Ricardo Pretto , Klafke André
Published: April 2022

Introdução: Infecção urinária é motivo comum de consulta na Atenção Primária, requerendo tratamento empírico. Para a seleção do antimicrobiano, é necessário conhecer o perfil de resistência dos uropatógenos na comunidade. Objetivo: Analisar o perfil de resistência antimicrobiana em uroculturas realizadas em pacientes da Atenção Primária à Saúde do Serviço de Saúde Comunitária do Grupo Hospitalar Conceição, de julho de 2017 a junho de 2019. Métodos: Estudo transversal, observacional e descritivo com uroculturas de pacientes ambulatoriais das Unidades de Saúde do Serviço de Saúde Comunitária do Grupo Hospitalar Conceição, nas Zonas Norte e Nordeste de Porto Alegre, de julho de 2017 a junho de 2019. Os dados das uroculturas foram fornecidos pelo laboratório do Grupo Hospitalar e analisados por meio das proporções, por sexo, micro-organismo e resistência antimicrobiana. Resultados: Encontraram-se 2.000 uroculturas positivas no período, principalmente por Escherichia coli (75,50%), Klebsiella pneumoniae (7,80%), Staphylococcus saprophyticus (4,95%), Enterococcus specie (3,35%) e Proteus mirabilis (2,85%). Entre os antibióticos orais testados, a maior resistência foi para ampicilina (48,95%), seguida por sulfametoxazol+trimetoprima (25,85%), norfloxacino (18,05%), ciprofloxacino (18,00%), amoxicilina+clavulanato (11,05%) e nitrofurantoína (8,60%). Considerando-se apenas E. coli, as resistências foram 47,75% para ampicilina, 29,74% para sulfametoxazol+trimetoprima, 19,74% para norfloxacino e ciprofloxacino, 8,08% para amoxicilina+clavulanato e 1,99% para nitrofurantoína. Conclusões: O perfil de resistência antimicrobiana nas Zonas Norte e Nordeste de Porto Alegre sugere que sejam utilizados para tratamento empírico de infecção do trato urinário nessa localidade nitrofurantoína ou amoxicilina+clavulanato.
Studying the Adsorption of Penicillin (G) Antibiotic on the Surface of Carbon Nanotubes by Molecular Docking
Authors: Pirahanforoosh Mandana , Ahmadi Roya , Yousefi Mohammad
Published: April 2022

Background: This research intended to evaluate the adsorption of single-walled carbon nanotubes (SCNT) with penicillin (G) antibiotic agent at the B3LYP/6-31G (d) theoretical level. Methods: First, we optimized penicillin (G) antibiotic and SCNT structures using the Gaussian program. Next, ten complexes with negative binding energy and steady-state than other cases were calculated using the molecular docking method and its ranking algorithm. Then, graphene was used to perform molecular orbitals calculations for the most stable configurations. Finally, binding energy and thermodynamic parameters were calculated at 298 K and 1 atm. Results: According to the findings, the adsorption of penicillin (G) antibiotic on the surface of carbon nanotubes was an exothermic, spontaneous process. Conclusions: This study indicated the ability of SCNT, as a sensing material, to construct thermal and electrochemical sensors for penicillin (G) determination.
Triosephosphate Isomerase Deficiency: The First Case Report from I.R. Iran
Authors: Vafaie Majid , Mahram Manoochehr , Farshadmoghadam Hossein
Published: April 2022

Introduction: Triosephosphate isomerase (TPI) deficiency is an autosomal recessive disease and the most severe form of glycolytic enzymopathies, characterized by hemolytic anemia, neurological disorders, infections, and muscle weakness that can affect breathing and heart function. Signs and symptoms include anemia, pallor, jaundice, fatigue, shortness of breath, muscle weakness, atrophy, movement problems, dystonia, tremors, seizures, cardiomyopathy, and diaphragm weakness. Case Presentation: A three-day female newborn was admitted because of hemolytic anemia. All usual assessments for hemolysis, G6PD, osmotic fragility, RBC morphology and cell panel, minor blood groups, antibody screening, and echocardiography were normal. Neurological manifestations appeared after six months of age, including some seizure-like movements, dystonia, and opisthotonus. Whole exome sequencing confirmed the diagnosis of TPI deficiency with the variant NM-000365.5:c.315G>C chr12-6978338(hg19) which revealed the mutation of p.Glu105Asp. By the age of two years, in addition to some drugs for neurologic manifestations and folic acid, the patient was hospitalized every 30 - 45 days for blood transfusion or because of pneumonia. The episodes of pneumonia increased after 24 months of age, and finally, the child expired at the age of 34 months due to pneumonia and respiratory failure. Conclusions: Triosephosphate isomerase deficiency should be considered in all neonates with hemolytic anemia without usual causes.
Effect oF TiO2 Nanoparticles and Curcumin on Sperm Parameters in Response to Temperature-Induced Stress in Scrotal Hyperthermia Rats: Role of miR455
Authors: Mollaei Maryam , Hashemi Mehrdad , Siasi Elham , Jafari Marndi Sayeh , Entezari Malihe
Published: April 2022

Background: Temperature changes cause testicular dysfunction. It has been observed that testicular hyperthermia leads to oxidative stress and as a result a severe reduction in testicular parameters. Causes a severe reduction in Sperm parameters to become oxidative due to stress. Recently, natural plant materials and magnetic nanoparticles have been considered. In the internal mitochondrial apoptosis pathway, gen bcl2 is a target of miR455. Objectives: The present study aimed to investigate the effects of titanium dioxide nanoparticles and improve their impacts by using the antioxidant curcumin on sperm parameters by investigating changes in expression miR455 in response to temperature-induced stress in scrotal hyperthermia rats. Methods: After preparation, the rats were placed in a hot water bath at 43°C. for 30 minutes for six consecutive days. The rats were then divided into eight groups. We used TiO2 nanoparticles at a concentration of 0.03 mg/kg of body weight and curcumin at a concentration of 0.02 mg/kg of body weight. After killing the animals, such parameters of sperm as viability, concentration, motility, and morphology of spermatozoa were studied. RNA extraction and cDNA synthesis were performed using appropriate kits. A gene primer was designed and RT-PCR was used to assess gene expression. The t-test and ANOVA were used to examine differences between different groups. Data analysis was performed using Prism8 software and SPSS version 26. Results: The results showed that miR455 expression was lower in the treatment groups and was associated with curcumin (P < 0.05). A positive effect of curcumin on improving sperm parameters in rats with scrotum hyperthermia and a negative and toxic effect of TiO2 nanoparticles were shown. However, a significant improvement in sperm parameters was observed when rats were given TiO2 nanoparticles along with curcumin. Conclusions: The changes in the expression miR455, shown in curcumin have controlled the damage to TiO2 nanoparticles. It seems that miRNA455 can be used as a marker to predict sperm health status. So Curcumin can play a protective role in reducing the toxic effects of testicular hyperthermia as well as titanium dioxide nanoparticles.
Retrospective Study of COVID-19 Positive Paediatric Patients Admitted in a Tertiary Care Hospital, Mizoram, India
Authors: Fanai Elizabeth Lalhmangaihzuali , Khiangte Zonuntluangi , Chhakchhuak Lalrintluangi , Anusuya Ganesh Shanmugasundaram , Patki Swati Manoj , Ralte Jenny Lalduhawmi , Fanai Remthangpuii , Hrahsel Larinawmi
Published: April 2022

Introduction: The clinical presentation and the difference in the pattern of presentation of Paediatric Coronavirus Disease-2019 (COVID-19) positive cases between the first wave and second wave have not been studied in North Eastern region of India. Aim: To study the socio-demographic factors, clinical presentations and also to compare the pattern of presentation of Paediatric COVID-19 positive cases between the first COVID 19 wave and second COVID-19 wave. Materials and Methods: A retrospective observational study of 85 Paediatric COVID-19 positive cases admitted in Zoram Medical College, Mizoram, India, during the period from July 2020 to June 2021 was conducted. Children of age group <14 years were included in the study. The data like age, sex, type of testing done, possible primary contact, symptoms , treatment given and prognosis were collected from the case sheets in Medical Records Department. Descriptive analysis was carried out by mean and standard deviation for quantitative variables, frequency and proportion for categorical variables. Categorical outcomes were compared between study groups using Chi square test/Fisher's Exact test. Results: Records of total of 85 participants were included in the final analysis. The mean age of the study population was 6.59 years. 40 (52.94%) were male patients. Majority , 46 (54.11%) have contracted the infection from their parents. The most common symptoms reported were fever (36.47%), cough (24.71%) and cold (22.4%). A total of 9.42% had co-morbidity. The mean duration of hospital stay was 10.14±5.2 days. In age group <5 years, (58.33%) were symptomatic when compared with 5 to 10 years (16.67%) and 25% in children >10 years (p-value= <0.001). There was a significant difference in the mean age group admitted in first wave (2.91±2.94 years) versus second wave (11.38±2.91 years) (p-value <0.001). Conclusion: The children less than 5 years were more symptomatic when compared with other age groups. Also we can see a transition in age group being infected and it was greater than 10 years old in the second wave. Hence there is an urgent need to vaccinate the population less than 18 years old.
When the Digital Media do the Magic of Effective Advertising of Health Supplements in Owerri Metropolis
Authors: Fatima Emetumah, I. , Okorie Ada G. , Duru Ngozi , Uche Macaulay S. , E. Nwamaka Nosike, , Emeka Etumnu W.
Published: April 2022

Today, people depend on the digital media in order to get information that will make them stay healthy. The digital media have become indispensable in the field of advertising and health because of its numerous benefits. This study investigated the effectiveness of digital media platforms in advertising of health supplements in Owerri metropolis. The elaboration likelihood model was adopted as the theoretical foundation. The survey research approach was used. The study had a population of 555,500 from which 384 was derived as the sample size using Wimmer and Dominick online sample size calculator. The multistage sampling technique was used. Questionnaire served as the instrument for data collection and the simple percentage was used for the data analysis. Findings revealed that 69.3% of the respondents confirmed that advertisements of supplements on digital media platforms promote sales of health supplement products among consumers. It was also revealed that at an average of 66.3% respondents confirmed that digital media have been effective in the advertisement of health supplements in Owerri metropolis. Further findings revealed that many of the respondents 111 (31.2%), were of the view that societal ideologies stand tall as challenges that hinder the acceptance and patronage of these supplements in Owerri metropolis despite the digital media advertisement. It was recommended that advertisers should not stop being creative in their advertising outings on the digital media so as to keep influencing consumers positively and to maintain its effectiveness in the promotion of health supplement products.
Examining the Effectiveness of the Wash Programme on Public Health in Public Schools in Kisumu East Sub-county, Kenya
Authors: Omwami Duncan O. , Kurauka Joseph K. , Ochola Samuel O.
Published: April 2022

As a result of poor hygiene in schools, public health and the status of public schools are adversely affected. There have been limited programs addressing sanitation issues in Kisumu East schools. This study therefore aimed at evaluating the effectiveness of the WASH program and teachers' contributions to improving the quality of latrines in Kisumu East and investigating the environmental factors that have had an impact on the quality of latrines. A total of 20 schools participated in the study interviews, of which 16 schools were involved in the WASH program, and 4 were not involved in the WASH program, with a target population of 384 students and 40 teachers. A descriptive research design was used to guide the investigation. The data was processed and analyzed using the Statistical Package for Social Sciences Version 25.0 software package, and data was presented in the form of means and variance. Tables were also used to display the data. Students and teachers in non-WASH schools agreed that the latrines were filthy. For instance, 62.5 percent of teachers and 62.3 percent of students from schools implementing the WASH program reported that latrines were dirty. Still, only 37.7 percent of teachers and 37.5 percent of students reported that they were very dirty. The study found an association between teachers' contributions and cleanliness, with a correlation coefficient (r) of -3.18 and a significance level of (p0.05). There was also a correlation between the implementation of WASH and the number of cases of diarrheal disease among students, with a significance value of 0.001*. It was concluded that the WASH program had a significant impact on the state of public health in public schools. Therefore, the study recommends that more effort should be put into addressing the challenges facing toilet cleanliness and hygiene practices.
Anti-competition Agreements on Agricultural Fertilizers between Cause and Effect
Authors: Popescu Lavinia , Safta Adela Sorinela
Published: April 2022

The total link between plant protection products and agricultural productivity is investigated empirically in this research. The study gives statistics on the economic impacts of expanding fertilizer sales, so we raise important concerns about the cause for the expansion, which creates this growth, need or excessive consumption, according to a range of research. Fertilizer management and monitoring in accordance with the Common Agricultural Policy (CAP), with the application of the correct quantity of nitrogen at the correct time as the foundation for successful fertilizer management. The paper also looks into some of the effects of climate change on agriculture; research shows that carbon absorbers are just as important as reducing emissions, and that the two are closely linked. The findings and information on the effectiveness of agricultural methods of high-performance farms ready to provide sustainable food supply systems provide people the confidence to consume organic goods in order to ensure that their bodies are healthy. This article addresses the topic of competition law violation in the context of imports of nitrogen-based fertilizers, in this case urea, as a product utilized in agriculture, using a subject and predicate method.
A Contemporary Role of Beta Blockers in Myocardial Infarction
Authors: Bansal Shyam Sunder , Chetan .
Published: April 2022

Myocardial infarction (MI) is characterized by plaque formation in the inner layer of arteries which occurs due to insufficient or complete cessation of oxygen supply in the myocardium. The common symptoms of MI are crushing or squeezing chest pain which radiates to the arms, shoulders, neck, or jaw, nausea, anxiety, restlessness, fear, heartburn, shortness of breath, cold sweat, fatigue, and dizziness. The treatment of this medical condition includes antiplatelet and thrombolytic therapy, painkillers (morphine or meperidine), diuretics and digitalis glycosides drugs. Moreover, nitroglycerin and antihypertensive drugs such as Beta-blockers, ACE inhibitors, or Calcium channel blockers may also be administered to reduce the blood pressure and improve the oxygen supply in the heart. Among them, beta blocker therapy has several beneficial properties such as it reduces myocardial oxygen demand, preventing arrhythmias, and improves ventricular remodeling, etc. However, there is no study on the role of only beta blocker therapy in the survival of MI patent is found to date. Thus, the present study focused on the evidence-based validation of Beta blocker therapy in the treatment and survival of MI patients. The retrospective study was conducted on 51 MI patients under the observation of medical practitioners. 100% of patients with MI showed a good recovery as well as survival percentage with Beta blocker therapy. This study finally concluded that beta blocker therapy is a safe and effective treatment for MI patients with negligible life-threatening medical conditions. Furthermore, a large group study is suggested with a number of health-related parameters for a better understanding of beta blocker as a first line of treatment for MI patients.
Pummelo: A Potential Underutilized Nutraceutical Crop for Multiple Health Benefits
Authors: Singh Hemlata , Prasad K. , Kumar Krishna
Published: April 2022

Phytochemical-rich fruits are gaining attention worldwide due to a rise in consumer awareness of the nutraceutical potential of these phytochemicals. Consumers prefer such fruits for maintaining good health as they play an important role in the prevention of many diseases. One such wonder crop is ‘Pummelo’ (Citrus maxima). Pummelo is a member of the citrus family and bears exceptional medicinal benefits. The literature survey revealed that this fruit is a rich source of phytochemicals and bears several pharmacological properties viz. antioxidant, antidiabetic, hepatoprotective, anticancer activities, etc. Despite its tremendous nutritional benefits, it is considered an underutilized fruit in India with limited use i.e. majorly for domestic consumption. For increasing the consumption and availability of this important fruit crop to the Indian population, there is a need to develop processed value-added products. This review aims to put light on the immense nutritional value and value-added products of pummelo. The value-added products of pummelo have nutraceutical value, there is a lot of scope in preparing phytochemical-rich value-added product in near future as this area of research still need to be explored.
Effect of Nitrogen-fixing Bacteria on Germination, Seedling Vigour and Growth of Two Rice (Oryza sativa L.) Cultivars
Authors: Bandeppa Sonth , Phule Amol S. , Rajani G. , Babu K. V. Prasad , Barbadikar Kalyani M. , Babu M. B. B. Prasad , Mandal P. K. , Sundaram R. M. , Latha P. C.
Published: April 2022

To evaluate the effect of isolated nitrogen fixing plant growth-promoting bacteria (PGPB) on seed germination and growth promotion of rice cultivars (cv. BPT 5204 and Improved Samba Mahsuri). Eight promising N-fixing PGPB along with two standard cultures (viz. B. japonicum and G. diazotrophicus) were inoculated as seed treatment to rice genotypes and the effect on seed germination, seed vigour index and plant growth promotion of rice cultivars was assessed under in vitro (agar method) and in vivo (pot experiment) net house conditions. PGPBs (viz., Paenibacillus sonchi IIRRBNF1, Paenibacillus sp. IIRRNF2, Ochrobactrum sp. IIRRNF3, Burkholderia cepacia IIRRNF4, Burkholderia sp. IIRRNF5, Stenotrophomonas sp. IIRRNF6, Rhizobium sp. IIRRNF7 and Xanthomonas sacchari IIRRNF8) were enhanced seed germination, seed vigour index, seedling growth and dry matter accumulation (root and shoot dry matter) of rice cultivars under in vitro as well as in vivo conditions. Among all PGPB, Paenibacillus sonchi IIRRBNF1 exhibited the highest ability to stimulate plant growth promotion under both the conditions. The eight PGPB isolates exhibited positive influence on seed germination indices as well as growth promotion traits of rice cultivars at seedling stage and can be further evaluated at different growth stages under pot and field experiment.
Influence of Different Levels and Methods of N P K Fertilizer Application on the Growth and Production of Wheat (Triticum aestivum L.) in Arid Region of Rajasthan
Authors: Nitharwal Praveen Kumar , Chauhan P. S. , Mandeewal Rameshwr Lal , Shivran Hansraj , Sharma Ashish Kumar , Ramniwas . , Sunita .
Published: April 2022

A field experiment was conducted at Instructional Farm, Swami Keshwanand Rajasthan Agricultural University, Bikaner during rabi season of 2019-20 to find out the Influence of different levels and methods of N P K fertilizer application on the growth and production of wheat (Triticum aestivum L.) in Arid Region of Rajasthan. The experiment was laid out with 20 treatment combinations comprising in a split plot design and replicated three times. The treatment consisted of four fertility levels in main plot, viz. F0 - control, F1 - 50% recommended dose of fertilizer (RDF), F2 - 75% recommended dose of fertilizer (RDF), F3 - 100% recommended dose of fertilizer (RDF) and five foliar fertilization with soluble N P K in the sub plot viz. S0- control (no spray), S1- one spray (60 DAS), S2- two spray (45 & 60 DAS), S3- three spray (45, 60 & 75 DAS), S4- four spray (45, 60, 75 & 90 DAS). The results revealed that 100% recommended dose of fertilizer resulted in significantly higher growth and yield attributes as well as grain and straw yield over all other fertility levels. Application of 100% RDF recorded significantly maximum gross and net profit (₹ 108568 ha-1 and ₹ 76682 ha-1) with B:C ratio of 2.40 over the other applied treatments. Similarly, three foliar spray of soluble N: P: K recorded maximum growth and yield attributes as well as grain and straw yield of wheat over rest of treatments but remained statistically at par with four foliar spray. The same treatment also recorded significantly higher gross & net returns (₹ 98116 ha-1 and ₹ 67326 ha-1, respectively) with B: C ratio of 2.16 in comparison to rest levels of foliar fertilization except four foliar spray of soluble N: P: K.
Overview of Brazilian Malaria Incidence from Environmental, Economic and Spatial Factors in the Amazon and Extra Amazon Region
Authors: Rodrigues Marcus Vinicius Carvalho , Souza Isabela Soares De , Costa Letícia Martins Veras , Neto José Coelho Da Silva , Leão Sarah Amorim , Coelho Bruna Da Silva , Silva Leydinaria Pereira da , Milhomem Ricardo Moreira , Silva Karla Cristina Assis , Oliveira Patricia Midom Di Napoli , Rodrigues Mariana Carvalho , Veras Pillar Barros , Nunes Bruno Henrique Di Napoli
Published: April 2022

Malaria is caused by the protozoan Plasmodium and its infection can occur in several ways, being the most common through the bite of the female mosquito Anopheles darlingi. The life cycle of the vector is related to the dynamics of the ecosystem, situations such as global warming generate a great concern regarding the possible amplification of the reproduction capacity of vectors according to climate change. These diseases are much more frequent in regions where the climate is tropical, such as Brazil. The incidence of the vector is characterized by several factors, such as biological, ecological, sociopolitical, cultural, and economic factors, the latter influence health expenditures in Brazil regarding the preventive measures of infection. The economic impact includes expenses with any health care, lost service days, loss of classes in the education system, as well as lower income at work due to brain injuries, among others. Malaria breeds poverty and poverty breeds Malaria. Through the Factorial Planning method: A brief review, data were collected in all Brazilian regions affected by the disease. The research strategy consisted of the use of the keywords in English: 1. Climate Change in Brazil; 2. Anopheles Darlingi vector life cycle; 3. Impact of climate change on the life cycle of Anopheles Darlingi; 4. Sensitive socioeconomic factors. Finally, this set of data suggests that public health programs act strategically in the population conjuncture, on the fronts of prevention, diagnosis, and treatment of the disease.
Quantitative Interpretation of Petrophysical Parameters for Reservoir Characterization in an Onshore Field of Niger Delta Basin
Authors: Adekunle Sofolabo O. , Desmond Osayande , Nwakanma Alexander
Published: April 2022

Reservoir characterization of a field was performed using petrophysical parameters for the evaluation of subsurface geological features and hydrocarbon potential of an onshore field in Niger Delta Basin. Four reservoir intervals were identified within the field wells based on their position within the stratigraphic column, and the reservoir correlation, which was aided using the principle of uniform horizontality, based on the simple rule that sediments are deposited horizontally and basic understanding of sequence stratigraphy. The study revealed that, the four reservoirs were predominantly sand units intercalated with shale within the reservoir units. The petrophysical evaluation revealed the Net to Gross (NTG) values ranges from 79% to 87% within the reservoir units, while the effective porosity ranges from 17% to 21%, the permeability ranges between 1307mD to 1678mD across the reservoir units, while the water saturation ranges from the lowest of 35% (reservoir C) to 78% in reservoir D. The approach validates the lithology discrimination of the elastic properties from the well logs and its effectiveness in optimizing and proper understanding of the subsurface, thus identifying and unmasking hidden features within the reservoir (probable bypass) in the field. The study has revealed that petrophysical parameters can be used quantitatively to characterize a field in terms of its lithology and fluid contents of the reservoir.
Analytical Tools Used for Characterization and Development of Minitablets: A Verapamil Hydrochloride Case Study
Authors: Kumar Bimireddy Bhavani Prasanna , Nadendla Rama Rao
Published: April 2022

Various analytical techniques were used at different stages of formulation development to assess the interactions and quality throughout the lifecycle of the verapamil hydrochloride minitablets (VHMT). At initial stage of development studies, pre-formulation analytical techniques like Fourier transform infrared (FTIR) and Differential scanning calorimetry (DSC) used to evaluate the interactions between the drug substance with different inactive ingredients and physicochemical properties of drug substance, which provided the groundwork for the development of robust formulation. A part of physicochemical properties, the solubility data of verapamil hydrochloride (VH) exhibited that pH dependent solubility throughout the physiological buffer media from pH 1.2 – 6.8, as pH of media increase solubility decrease due to the weak basic nature of VH. To improve the solubility of VH, fumaric acid was included in the formulation. The analytical data of FTIR and DSC showed that no chemical interaction with selected excipients. The formulation analytical quantitative techniques like a stability indicating HPLC assay procedure has been developed and validated for VHMT life cycle (initial and stability samples). The analytical data of stability samples of VHMT showed stable upto 3M at 40°C. The pre-formulation data at initial development stage and the stability data of final product evidences that the final drug product was developed with desired release characteristics without any instability issues. In conclusion, the combined use of pre-formulation and formulation analytical techniques helped to identify the defects at early stage of development and overcome those shortcomings by appropriate scientific approach, which significantly minimized the formulation failure at later stage.
The Community's Perception and Participation in the Project Plan for Merchant Arrangement and Visitor Parking at Borobudur Temple
Authors: Isworo Slamet , Oetari Poerna Sri , Pramaningsih Vita , Rusmadi .
Published: April 2022

Background and Objective: The perception and participation of the community are required for development to be successful. Perception and participation play critical roles in the regional development process. The goal of this study was to determine the community's perception and involvement in the Arrangement of Merchant and visitor parking in the Borobudur temple area. Method: Methods of mixed descriptive research. The study was carried out between March 25 and March 28, 2021. The respondent group was divided into three groups: the community living around the project plan (56 respondents), merchants in the Borobudur Temple tourism area (59 respondents), and landowners (35 respondents).

Result: Based on the survey results, the community, in general, has a positive perception of the overall project plan, especially in the community groups/strata around the project (78.6                  percent) and the landowners (96.7 percent). The public consultation activity held on Thursday, January 28, 2021, resulted in constructive suggestions and input. In the event, members of the Environmental Impact Analysis Commission were elected as community representatives, consisting of 8 representatives of merchants and 7 representatives of the surrounding              community.

Conclusion: Some people have a positive perception of the relocation project for the parking locations of merchants and visitors at Borobudur Temple, while those who have a negative perception get an understanding after participating in the socialization of the preparation of the Environmental Impact Analysis document.
Vocalização Materna no Contexto da Prematuridade e UTI Neonatal: Uma Revisão Narrativa
Authors: Damiani Natália B. , Piccinini Cesar A;
Published: April 2022

he aim of this study was to examine empirical evidence published between 2015 and 2020, involving maternal vocalization and premature babies in the context of Neonatal Intensive Care Unit (NICU). Damiani, N. B., Piccinini, C. A.2Cadernos de Psicologia, Ribeirão Preto, vol. 1, nº 1, p. 1-21 - Abril/2022This is a narrative review of the literature found in PsycINFO, PubMed, LILACS, MEDLINE and CINAHL. Seventeen studies were included and analyzed according to the following categories: aims, participants, design, procedures and interventions, instruments and main results. It was observed that the vast majority of studies focuses on the diff erential impact of the mother’s voice, both speaking and singing, on the baby and uses an experimental or quasi-experimental design. The results reveal reduction in heart rate, increase in oxygen saturation, reduction in pain indicators and increased alertness in babies. Furthermore, babies exposed to the intervention using their mother’s voice in the NICU context had a signifi cant increase in auditory cortex thickness, and developed language skills compared to those exposed only to routine care. Studies investigating the characteristics of the maternal voice have reported an increase in tone and volume in the presence of a smile and the opening of the baby’s eyes, and greater emotional stability in mothers who used their voices. In general, the studies yield positive yet heterogeneous results concerning the maternal voice’s impact in this contex
Humor Racista: Uma Revisão Sistemática de Estudos
Authors: Araujo Camilla L. , Gois Diego F.
Published: April 2022

he present study aims to analyze the scientifi c production of studies from diff erent areas that focused on racist humor. For the analysis, a systematic review was carried out in the Scielo Brasil and Portal Periódicos CAPES databases in April 2021. The search used the keywords racism, humor and joke. After applying the inclusion and exclusion criteria, 42 articles remained in the sample. For the analysis, the abstracts of the articles composed a textual corpus that was submitted to lexical analysis with the help of the IRAMUTEQ software. The results indicate that the topic has been researched from six diff erent thematic axes: racist humor on platforms, critical discussion of racist humor, blackface, racist Araujo, C. L., Gois, D. F.2Cadernos de Psicologia, Ribeirão Preto, vol. 2, nº 1, p. 1-13 - Abril/2022and everyday humor, racist humor and interracial groups and racist humor and politics. However, we identifi ed a small number of scientifi c publications ahead of the need for debate on the topic of racist humor and racism, especially in the fi eld of psychology. Furthermore, there is a need for studies that aim to analyze the impact and understanding of the phenomenon from the perspective of those aff ected
Blended learning in a biology classroom: Pre‐pandemic insights for post‐pandemic instructional strategies
Authors: Tahir Irtaza , Van Mierlo Victoria , Radauskas Victoria , Yeung Wayne , Tracey Alastair , da Silva Rosa
Published: April 2022

It is increasingly important to utilize novel approaches to improve student learning. This has become especially relevant throughout the COVID‐19 pandemic. Previous studies have shown positive outcomes of blended learning on student satisfaction. Yet, there are limited data in the field of biology on how blended learning practices correlate with overall student performance. Moreover, there is a dearth of information on student perceptions about how blended learning has impacted their education. Through this study, we present insights on the impact of blended learning in a first‐year cell and molecular biology course. Using mixed‐methods research, we evaluated the impact of a blended learning course format on student performance in the learning categories of knowledge and understanding, communication and application, and critical thinking and inquiry. Using a pre‐ vs. postintervention analysis, we show that a blended learning course model does not change students’ performance on multiple‐choice and short answer assessments when compared to a nonblended learning course model. Through a qualitative assessment of student perceptions and sentiments, however, the implemented blended learning approach does appear to provide significant perceived benefits, including learner flexibility, consolidation of content, and the opportunity to apply course content to the ‘real world’. While we recognize that our report describes a very specific blended learning model, we believe that our findings are generalizable to similar introductory courses. As such, we are confident that our case study will provide course designers with a useful foundation to build future blended learning courses.
Sciatic nerve microvascular permeability in type 2 diabetes decreased in patients with neuropathy
Authors: Jende Johann M. E. , Mooshage Christoph , Kender Zoltan , Schimpfle Lukas , Juerchott Alexander , Heiland Sabine , Nawroth Peter , Bendszus Martin , Kopf Stefan , Kurz Felix T.
Published: April 2022

Objectives

Clinical and histological studies have found evidence that nerve ischemia is a major contributor to diabetic neuropathy (DN) in type 2 diabetes (T2D). The aim of this study was to investigate peripheral nerve microvascular permeability using dynamic contrast enhanced (DCE) magnetic resonance neurography (MRN) to analyze potential correlations with clinical, electrophysiological, and demographic data.

Methods

Sixty‐five patients (35/30 with/without DN) and 10 controls matched for age and body mass index (BMI) underwent DCE MRN of the distal sciatic nerve with an axial T1‐weighted sequence. Microvascular permeability (Ktrans), plasma volume fraction (vp), and extravascular extracellular volume fraction (ve) were determined with the extended Tofts model, and subsequently correlated with clinical data.

Results

Ktrans and ve were lower in T2D patients with DN compared to patients without DN (0.037 min−1 ± 0.010 vs. 0.046 min−1 ± 0.014; p = 0.011, and 2.35% ± 3.87 vs. 5.11% ± 5.53; p = 0.003, respectively). In individuals with T2D, Ktrans correlated positively with tibial, peroneal, and sural NCVs (r = 0.42; 95%CI = 0.18 to 0.61, 0.50; 95%CI = 0.29 to 0.67, and 0.44; 95%CI = 0.19 to 0.63, respectively), with tibial and peroneal CMAPs (r = 0.27; 95%CI = 0.01 to 0.49 and r = 0.32; 95%CI = 0.07 to 0.53), and with the BMI (r = 0.47; 95%CI = 0.25 to 0.64). Negative correlations were found with the neuropathy deficit score (r = −0.40; 95%CI = −0.60 to −0.16) and age (r = −0.51; 95%CI = −0.67 to −0.31). No such correlations were found for vp.

Conclusion

This study is the first to find associations of MR nerve perfusion parameters with clinical and electrophysiological parameters related to DN in T2D. The results indicate that a decrease in microvascular permeability but not plasma volume may result in nerve ischemia that subsequently causes demyelination.