bluuebunny/crossref_metadata_2025 huggingface dataset:
Leisure-Time Physical Activity is Associated with reduced Risk of Breast Cancer and Triple Negative Breast Cancer in Nigerian Women: a matched case-control study
Authors: Bigman Galya , Adebamowo Sally N. , Yawe King-David Terna , Yilkudi Monday , Olaomi Oluwole , Badejo Olawale , Jedy-Agba Elima , Famooto Ayo , Ezeome Emmanuel , Salu Iliya Karniliyus , Miner Elijah , Anosike Ikechukwu , Achusi Benjamin , Adebamowo Clement
Published: September 2019

Background

Physical activity is associated with reduced risk of breast cancer and its various subtypes but this association is less known in African women, particularly with triple-negative breast cancer that occurs more frequently in Sub-Saharan Africa compared to developed countries. In this study, we examined the association between leisure-time physical activity (LTPA) and breast cancer in total and by its subtypes in Nigerian women.

Methods

Overall, 630 newly diagnosed patients with primary invasive breast cancer were age-matched (±5years) with 630 controls from the Nigerian Integrative Epidemiology of Breast Cancer (NIBBLE) Study from 01/2014-07/2016. We derived the average amount of time spent on LTPA per week over the past year using a modified Nurses’ Health Study-II physical activity questionnaire. We calculated the total metabolic equivalents (METs) for each reported LTPA per hour/week (i.e. walking, cycling, and dancing) and compared odds of breast cancer among participants who attained the World Health Organization (WHO) physical activity(PA) recommendations of at least 150 minutes of moderate-intensity or/and 75 minutes of vigorous-intensity aerobic activity/week with those who did not. In addition, we evaluated this by categories of LTPA in quartiles of METs. We used conditional and unconditional logistic regression models to estimate the adjusted Odds Ratio(OR) of LTPA with overall breast cancer and by hormone receptor-positive and triple-negative breast cancer.

Results

The mean ages of cases and controls were similar after matching, 42.5±10.1 and 41.5±9.2 years (mean±SD), respectively. Women who attained the WHO PA recommendations had a 42% reduction in the odds of having breast cancer(OR=0.58 95% CI:0.43-0.78) compared with those who did not. LTPA was associated with reduced odds of having hormone receptor-positive by 41% and significantly associated with reduced odds of having triple-negative breast cancer by 45%. In addition, a significant dose-response relationship was observed, women with higher levels of LTPA had lower odds of having overall breast cancer as well as having triple-negative and hormone receptor-positive breast cancer.

Conclusions

Increasing LTPA in African women can play a significant role in reducing the incidence of breast cancer, particularly of the more aggressive subtype as triple-negative, which is more prevalent in Sub-Saharan Africa.
GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy
Authors: Ueki Shunsuke , Fujishima Fumiyoshi , Konno Takuro , Ishida Hirotaka , Okamoto Hiroshi , Takaya Kai , Sato Chiaki , Taniyama Yusuke , Kamei Takashi , Sasano Hironobu
Published: September 2019

BackgroundEsophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. Glucocorticoid(GC)-Glucocorticoid receptor (GR) pathway plays pivotal roles in cellular response to various stresses of tumor cells including chemotherapy. However, the status of GC-GR pathway in ESCC, including its correlation with chemotherapeutic responses has remained largely unknown.MethodsGR, serum-and glucocorticoid-regulated kinase 1(Sgk1), and N-myc down regulation gene 1(NDRG1) were immunolocalized in 98 ESCC patients who had undergone esophagectomy following neoadjuvant chemotherapy(NAC) with 2 courses of 5-Fluorouracil(5-FU) + Cisplatin (CDDP). We also examined biopsy specimens before NAC in 42 cases and compared the results between those before and after NAC.ResultsOverall survival (OS) of the patients treated with surgery following NAC was significantly shorter in the group with high GR than that with low GR (P = 0.0473). Both OS and disease-free survival (DFS) were significantly shorter in both Sgk1- and NDRG1-high groups than low groups (OS: Sgk1, P = 0.0055; NDRG1, P = 0.0021; DFS: Sgk1, P = 0.0240; NDRG1, P = 0.0086). When evaluating the findings in biopsy specimens before NAC, DFS was significantly shorter in the high Sgk1 group (P = 0.0095), and both OS and DFS was shorter in high NDRG1 group (OS, P = 0.0233; DFS, P = 0.0006) than respective low groups. Among high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated (P = 0.021).ConclusionsHigh status of GR, Sgk1, and NDRG1 in ESCC after NAC was significantly associated with over all worse prognosis and there were no significant changes in the status of those above before and after NAC. Therefore , increased activity of GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells plays pivotal roles in tumor progression and development of chemoresistance in ESCC patients undergoing NAC.
Effect of microencapsulated Lactobacillus plantarum LIP-1 on cholesterol metabolism in hyperlipidaemic rats
Authors: Yao Caiqing , Tian Wenjing , Song Jiaojiao , Wang Junguo
Published: September 2019

Background: Previous studies have shown that Lactobacillus plantarum LIP-1 has obvious hypolipidemic effect, and microencapsulated probiotics can ensure the strains live through the gastrointestinal tract, although there has been much research on both preparation and assessment methods for probiotics microcapsules, most assessments are made in vitro and few are validated in vivo. In this study, the protective effect of microencapsulation and the possible hypolipidaemic mechanisms of probiotic Lactobacillus plantarum LIP-1 (hereafter LIP-1) were evaluated in rats. Methods: Treatments included rats fed on: normal diet, high-fat diet, high-fat diet with an intragastric supplement of either non-microencapsulated LIP-1 cells (NME LIP-1) or microencapsulated LIP-1 (ME LIP-1). Lipid metabolism indicators were measured during the experiment and following euthanasia. Results: Microencapsulation increased survival and colonization of LIP-1 in the colon. ME LIP-1 was superior to NME LIP-1 in reducing cholesterol. The mechanisms behind the hypolipidemic effect exerted by LIP-1 are possibly due to: promoting the excretion of cholesterol, improving antioxygenic potentials, enhancing recovery from the injury in the liver and intestinal mucosa, promoting the generation of SCFAs, and improving lipid metabolism. Conclusions: This study confirms the role of ME LIP-1 in the prevention and cure of hyperlipidemia and provides theoretical support for the probiotics to enter clinical use. Keywords: Microencapsulated LIP-1; non-microencapsulated LIP-1 cells; hypolipidaemic effect; lipid metabolism; antioxidative activity
How addicted are newly admitted Undergraduate Medical Students to Smartphones?: a Cross-sectional Study from Chitwan Medical College, Nepal
Authors: Karki Sirisa , Timilsina Sameer , Singh Jaya Prasad
Published: September 2019

Introduction Increasing smartphone use among adolescents in todays’ world has made this handy device an indispensable electronic tool, however, it comes at a price of problematic overuse or addiction. We aimed to investigate the prevalence of smartphone addiction among undergraduate medical students and explore its association with various demographic and personal factors.Methods A pool of 250 undergraduate students enrolled at Chitwan Medical College were included in this cross-sectional study conducted between August to November 2018. A preformed demographic porforma along with 10-point Smartphone Addiction Scale-Short Version was used to collect participant information.Results Smartphone addiction among medical students was estimated at around 36.8% with higher percentage of male smartphone addicts. Prevalence rates of smartphone related tolerance was reported in 42.8% participants, 37.6% reported phubbing and 60.8% participants reported overuse. Statistically significant association was observed between smartphone addiction and gender, self-acknowledgement of addiction and overuse.Conclusion This study provides preliminary insights into smartphone use, smartphone addiction and various factors predicting smartphone addiction among early undergraduate medical students from Nepal, which should be extended in future studies. Some fruitful programs and strategies to promote students’ knowledge and awareness about using smartphone seems to be the need of the hour.
Identification of key gene biomarkers and pathways related to Dent disease in CLCN5 knockout mice by bioinformatics analysis
Authors: Lin Zhijian , Wang Yu , Guo Fanfan , Zhang Bing
Published: September 2019

Background Dent disease is an X-linked inherited renal disease that occurs almost exclusively in males. Abnormal CLC-5 function might play a role in the development of Dent disease, but the genetic interaction changes and biomarkers in Dent disease are not fully understood. The aim of this study was to explore the potential key gene biomarkers and pathways related to Dent disease in CLCN5 knockout mice model.Methods The gene expression profile GSE10162 was analyzed differentially expressed genes (DEGs), between 3 samples of CLC-5 transporter gene knockout mouse model of Dent disease and 3 samples from wild type mouse. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied for the enriched pathway by the online tool DAVID. A protein-protein interaction (PPI) network of DEGs was constructed to find the hub genes by STRING, and visualized with Cytoscape software.Results Three samples from were incorporated into this study. A total of 500 DEGs were filtered, consisting of 231 upregulated genes and 269 downregulated genes. GO analysis indicated that the up-regulated DEGs were significantly enriched in the regulation of transcription form RNA, regulation of cell proliferation, and ion transport, whereas down-regulated genes were mainly enriched in oxidation-reduction process, and metabolic process. KEGG analysis demonstrated that the DEGs were enriched in the metabolic pathways, neuroactive ligand-receptor interaction, nicotine addiction, morphine addiction, fatty acid elongation, TNF signaling pathway, calcium signaling pathway, and cAMP signaling pathway. PPI network analysis found 17 hub genes with greater than 10 degrees of connectivity. The hub genes might participate in TNF signaling pathway, fat digestion and absorption, and enrich in lipid metabolic process, regulation of blood pressure, cellular response to hypoxia, positive regulation of angiogenesis, positive regulation of developmental growth, and positive regulation of cytosolic calcium ion concentration.Conclusions Our study suggests that Apob, Lep, C3, Cxcl1, Acly and Mmp9 may play key roles in the progression of Dent disease. Blood lipid profiles and calcium levels might be potential prognostic biomarkers for Dent disease.
The Antimicrobial Peptide MAF-1A Acts on the Transcriptional Response of Candida parapsilosis
Authors: Cheng Rong , Li Wei , Sample Klarke M. , Xu Qiang , Liu Lin , Yu Fuxun , Nie Yingjie , Zhang Xiangyan , Luo Zhenhua
Published: September 2019

Background
Candida parapsilosis is a major fungal pathogen that can cause sepsis in man. Novel antifungal agents are urgently required due to the threat of resistance to current therapeutic strategies. MAF-1A is a novel cationic antimicrobial peptide isolated from Musca domestica and is effective against a variety of Candida species. However, its antifungal mechanism is still unclear. Here, RNA-seq was used to identify differentially expressed genes (DEGs) in Candida parapsilosis after MAF-1A exposure. And then, we want to understand how the antimicrobial peptide MAF-1A work as an antifungal agent.
Results
The early (6 hour) response included 1122 genes with increased expression and 1065 genes with decreased expression. The late (18 hour) response was associated with the increased expression of 101 genes and decreased expression of 151 genes. When treated with MAF-1A from six to 18 hours, 42 genes were no longer expressed at elevated levels, and 25 genes that had a decreased expression pattern were reversed and demonstrated an increased expression pattern. KEGG enrichment showed that the DEGs caused by MAF-1A mainly involved amino acid synthesis and metabolism, oxidative phosphorylation, sterol synthesis and apoptosis.
Conclusion
These results indicate that MAF-1A may have multiple downstream effects in Candida parapsilosis. MAF-1A may exert antifungal activity by interfering with Candida parapsilosis cell membrane integrity and the function of certain organelles.
Barriers to sustained mother’s own milk feeding in newborns admitted to the neonatal intensive care unit or special care nursery.
Authors: Heller Nadja , Rüdiger Mario , Mense Lars
Published: September 2019

Background Breast milk feeding is the optimal nutrition for all neonates including preterm newborns. Factors influencing mother’s own milk (MOM) feeding at discharge need to be acknowledged and addressed appropriately.Methods Data was collected from electronic patient charts of the University Hospital Carl Gustav Carus, Dresden, Germany. All infants admitted to the neonatal intensive care unit (NICU) or special care nursery in the first two days of life during a period of three years were included. Multivariable logistic regression analysis was used to determine sociodemographic and medical factors associated with MOM feeding at discharge.Results At discharge, 54.9% of the infants were exclusively MOM fed, 44.4% of infants born ≥ 37 weeks, 56.1% of infants born between 32 and 36+6 weeks and 59% of infants born < 32 weeks gestation. In early preterm infants, first breastfeeding after the first 14 days of life, absent maternal nicotine abuse and vaginal delivery were associated with MOM feeding. For infants born 32 - 37 weeks, MOM feeding was more common with first breastfeeding after the first 14 days of life, lower birth weight and for women without gestational diabetes. For infants born ≥ 37 weeks MOM feeding was associated with first breastfeeding within the first 14 days.Conclusions A significant number of infants were not fed MOM at discharge. We identified groups that may benefit from targeted interventions to promote MOM feeding.
Gingival thickness assessment at mandibular incisors of orthodontic patients with ultrasound and cone-beam ct.
Authors: Kloukos Dimitrios , Kakali Lydia , Koukos George , Sculean Anton , Stavropoulos Andreas , Katsaros Christos
Published: September 2019

Background Quantitative and qualitative analysis of several periodontal parameters plays an important role in several dental procedures. Aim of the current study was to assess gingival thickness (GT) at mandibular incisors of orthodontic patients with two methods and determine how these methods are compared to each other when assessing periodontal anatomy through soft tissue thickness.Methods The sample consisted of 40 consecutive adult orthodontic patients. GT was measured at both central mandibular incisors, mid-facially on the buccal aspect, 2mm apically to the free gingival margin with two methods: a) clinically with an Ultrasound device (USD) and b) radiographically with Cone Beam Computed Tomography (CBCT).Results CBCT measurements were consistently higher than USD measurements, with the difference ranging from 0.13 mm to 0.21 mm. No difference was noted between the repeated CBCT measurements at the right central incisor (Bias= 0.05 mm; 95% CI= -0.01, 0.11, p=0.104). Although the respective results for the left incisor indicated, statistically, that the measurements were not exactly replicated, the magnitude of the point estimate was small and not clinically significant (Bias= 0.06 mm; 95% CI= 0.01, 0.11, p=0.014). Small differences between CBCT measurements made by the 2 examiners at the left central incisor (bias= 0.06 mm, 95% CI= 0.01, 0.11, p=0.014) were detected. However, this difference was minor, and again, not clinically significant. The respective analysis on the right incisor showed no significant difference (bias= 0.05 mm, 95% CI= -0.01, 0.11, p=0.246).Conclusions Present data indicate that CBCT measurements were highly reproducible and yielded greater values compared to USD measurements.
Protection of the public in a large-scale radiation accident: mitigation of negative social consequences of protective actions. Part 1. Interpretation of dose characteristics of emergency
Authors: Konstantinov Yu. O.
Published: September 2019

The protective actions which were carried out with the purpose to reduce public exposure to radiation derived from the accidents at Chernobyl and Fukushima-1 nuclear power plants have caused negative consequences of social – psychological both social-economic character and medical nonradiological consequences. The corresponding damage put to the population of involved territories and to the entire society has considerably exceeded hypothetical benefit of aversion of radiation exposure. In the present study some possible ways of aprioristic maintenance of mitigation of the social damage accompanying realization of anti-radiation protective actions at large-scale radiation accident are considered. For the characteristic of total amount of the damage caused by protective actions, the scale of radiation and social protection in terms of a population of officially involved territories is accepted. The analysis of decisions on protection of the population in the Russian Federation against consequences of Chernobyl accident shows that at concrete radiation situation scales of protective actions differ more than on the order of magnitude, depending on criteria of decision-making and their administrative realization. Another factor that determines the scale of the accident is the degree of conservatism in the assessment of the radiation situation. The analysis of results of individual dosimetric examination of inhabitants of the western districts of the Bryansk region has shown steady values of statistical characteristics of distribution of the individual doses of an external and internal radiation caused by Chernobyl accident, according to which the value of 95% quantile of distribution in 2–3 times exceeds the average value at an examined sample of the population. Thus, application of the concept of “representative person» leads to overestimation of projected doses concerning to those corresponding to stochastic radiation effects. The results of such overestimation are expansion of scales of protective actions, prolongation of emergency, increase in accompanying social damage. As one of the ways to maintain aprioristic mitigation of social damage accompanying protective actions, the following position is offered. At a stage of an emergency, when there is enough information to consider, that the maximal public exposure to radiation will not achieve thresholds of deterministic effects, the decisions on protective actions violating normal human beings and socioeconomic functioning of territory is justified to accept on the basis of doses for the average person, instead of those for the most exposed people.
Scientific and practical experience of supervisory activities in the field of the public and environmental protection at the Russian nuclear legacy sites
Authors: Shandala N. K. , Kiselev S. M. , Titov A. V.
Published: September 2019

Today, Russia is implementing a national program for the remediation of legacy sites, resulting from the activities of the nuclear industry, the use of nuclear energy for military purposes, and due to radiation accidents and emergencies. Main priority is given to the health care provision issues of the workers and the population living in the vicinity of the targeted facilities. These tasks are under the regulatory responsibility of the FMBA of Russia. Since the beginning of the development of the nuclear industry in the country, the Institute of Biophysics, technical supporting organization of the FMBA of Russia (now the State Research Center – Burnasyan Federal Medical Biophysical Center Federal Medical Biological Agency (SRC-FMBC)), has been a leading institute in the scientific and methodological support of public radiation safety in the vicinity of radiation hazardous facilities serviced by the FMBA of Russia. In this regard, radiation-hygienic monitoring has always served as the main regulatory tool for more than 60 years. The paper describes the results of long-term monitoring (2005-2018) at the former coastal technical bases of the Russian Navy ( now – sites for temporary storage of SNF and RW in the Russian Northwest and Far East (nuclear legacy sites); sites of the uranium mining and milling facilities: Priargun Mountain Chemical Association and former Production Association “Almaz” (Lermontov, Stavropol Krai); and at uranium legacy sites of the Central Asia (Republic of Tajikistan and Kyrgyz Republic). The peculiarities of radiation situation at the sites are discussed, current challenges identified, and further regulatory improvements presented based on the gained experience.
Scientific legacy of professor Pavel Vasilyevich Ramzaev
Authors: Onischenko G. G. , Zvonova I. A. , Balonov M. I. , Ramzaev V. P. , Repin V. S.
Published: September 2019

The article describes the main areas of scientific and administrative activities of professor P.V. Ramzaev during his work in the Research Institute of Radiation Hygiene. In particular, the results of a study of global radioactive fallout in the Far North of the USSR, as well as a study of the radiation situation and an assessment of the doses to the public after the accident at the Chernobyl NPP, are presented in a systematic way. The leading role of P.V. Ramzaev in the development of hygienic regulation and in the development of the theory of health is shown. The activities of P.V. Ramzaev in the International Commission on Radiological Protection are discussed in detail. The role of P.V. Ramzaev in the development of the law «On Radiation Safety of the Population» is shown.
The national radon program: Implementation experience and challenges for the future
Authors: Marennyy A. M. , Kiselev S. M.
Published: September 2019

The authors share their experience and represent the historical overview of activities on public radiation protection against radon and other natural sources of radiation in Russia. Special attention is paid to the country’s first national radon program - Federal Target Program “Radon” (FTP “Radon”, 1994-1996). Organization, structure, main goals and objectives of the FTP «Radon» are discussed. In particular, it was noted that in a short period of time the country’s regulatory and methodological framework was developed. The scientific basis for identification of the radon prone areas and regulatory support for building construction at the sites was developed. The national SSND equipment was produced and QA/QC system implemented. The national and regional radon surveys have been performed. Unfortunately, the economic situation of those years did not allow to fully implement the planned set of measures at the federal and regional levels. Nevertheless the accumulated experience served as a scientific and technical basis for further improvements in this field and to be consistent with the modern radon regulatory issues and approaches developed by the international organizations (ICRP, IAEA, WHO).
Occurrence of Anaplasma phagocytophilum in goats and sheep in Hebei Province, China
Authors: WANG QIUYUE , LI YUAN , ZOU YAXUE , LIU JIA , CHEN LIFENG , PAN SUMIN , LIU SHAOXIONG , LIU XIERONG
Published: September 2019

Anaplasma phagocytophilum is an emerging pathogen known to cause human granulocytic anaplasmosis (HGA). Here we determined the prevalence and genetic characterization of A. phagocytophilum in Hebei Province, China. A total of 253 samples were taken from goats and sheep in Hebei Province, and 52 (20.6%) were positive for A. phagocytophilum. There was a higher positive rate in sheep (23.8%, 20/84) than in goats (18.9%, 32/169). Analysis of the partial 16S RNA gene sequences of A. phagocytophilum revealed that the isolates in this study were members of the same clade and were 100% homologous with each other. This study provides information on the epidemiologic features of A. phagocytophilum.
Study of CO2 emissions from energy consumption in Spanish hospitals
Authors: García-Sanz-Calcedo Justo
Published: September 2019

Hospitals generate a high amount of carbon dioxide emissions into the atmosphere compared with residential and commercial buildings. Therefore, it is necessary to quantify and identify the CO2 emissions derived from energy consumption in hospitals, studying their relationship with functional variables. The aim of this article is to analyze the CO2 emissions derived from the hospital energy consumption. In Spain, 14 hospitals were analyzed, studying the built surface area and the number of beds in the period 2010-2014. The results showed that in a hospital, the average annual CO2 emissions divided by built surface area is around 0.10 Ton per m2, and the annual CO2 emissions divided by number of beds is around 13 Ton per bed. These ratios will make it possible to benchmark hospital management and set targets for limiting emissions into the atmosphere.
Effect of ultrasound waves on hematological parameters, behavior and conduction system of heart in vitro in BALB/c strain mouse
Authors: Bubulis Algimantas , Vėžys Joris , Žymantienė Judita , Želvytė Rasa , Oberauskas Vaidas , Sederevičius Antanas , Aniulienė Albina
Published: September 2019

In this study research was carried out on 5 male adult BALB/c mouse with a weight of 18±5 g. The temperature was at 22±2 °C and animals were kept under the condition of 12 h of light and 12 h of darkness (light on at 08:00 am) and free access to water and standard diet. All 5 mice were affected by three different harmonic oscillations one time and after 24 hours 4 of them were affected by the same oscillations (Fig. 1) and one was placed separately for control. At the end of the experiment, after euthanasia using CO2 chamber blood samples were collected by cardiac puncture. We noticed that ultrasound waves 20 MHz changed mice red blood cells structure and we found pathological forms of erythrocytes. Analysing morphological structure of erythrocytes were determined 46 abnormal red blood structure forms and atypical cells (30 codocytes, 8 stomatocytes and 8 acantocytes). Moreover, we determined that changed some normal behavior characteristics and increased grooming process.
The Method of Carbon-Dioxide Recovery in Fish-Processing Industry
Authors: Неверов Евгений , Neverov Evgeniy , Коротких Павел , Korotkih Pavel
Published: September 2019

There is a growing demand for rapid cooling in modern food industry. Traditional methods of fish cooling involve cold air, cold liquid, and ice. These methods have a number of disadvantages. For instance, they may have a negative effect on the appearance of the product, require a longer cooling time, or make fish absorb extra moisture. As a result, the quality of the product and its shelf life decrease, which results in demand contraction. Carbon dioxide is becoming increasingly popular in closed refrigeration systems. It is one of the most promising refrigerants, since traditional refrigeration technologies for fish cooling have a number of serious drawbacks. The paper introduces a utilization method for carbon dioxide obtained at alcohol processing plants. The authors analyzed the prospects of using carbon dioxide in combination with a binary mixture for cooling trout. A series of experiments proved the technological advantages of this technology. The paper features heat transfer in roundfish during cooling with water ice, a mixture of water ice and snow-like carbon dioxide, and snow-like CO2 in pure form. The obtained results show the effect of the concentration of snow-like carbon dioxide in water ice on the intensity of the cooling process. A higher intensity of the cooling process reduced the cooling time and the amount of water ice. The study of quality indicators of trout proved that the environment of water ice and carbon dioxide increased its shelf life by several times. The paper contains temperature graphs and duration curves at different concentrations of CO2.
Sheep’s Milk Camembert Ripening: Transformation of Fatty-Acid Profile
Authors: Вобликова Татьяна , Voblikova Tatyana , Садовой Владимир , Sadovoy Vladimir , Барыбина Людмила , Barybina Lyudmila
Published: September 2019

Sheep’s milk contains fatty acids that have a positive effect on human health. Besides, its production is economically profitable. Thus, fatty-acid profile of cheese and its transformation during maturing remain relevant for scientific research. The present research featured the quality of lipids during the fatty phase of soft-ripened Camembert-type cheese. Its fatty-acid profile was studied using a method of gas chromatography. A set of experiments established significant changes in the concentration of fatty acids during maturing. The concentration of short chain fatty acids increased, namely that of butyric acid (C4:0), butylacetic acid (C6:0), and hexylacetic acid (C8:0). The trend can be associated with the specific lipases produced by microorganisms during ripening. On day 14, the concentration of lauric acid (C12:0) increased by 30% and that of myristic acid (C14:0) – by 13%, as compared with day 1. The initial concentration of 18:1n9t isomer was about 70% of the total amount of trans-isomers of fatty acids. After maturing, its concentration decreased by 98%. The concentration of C10:0, C14:0, C16:0, C18:0, C18:1t11, and C18:1c9 fatty acids equaled 73% of the total amount of fatty acids during all periods of ripening. The concentration of hypercholesterolemic fatty acids increased and that of hypocholesteremic fatty acids decreased during ripening, which raised the Atherogenic and thrombogenic indices. Fatty acids with ≤ 12 carbon atoms were found characteristic of fatty acid profile of sheep’s milk Camembert. They can be used to detect other milk in sheep’s milk cheese.
Formulations and Nutrition Value of New Multicomponent Fruit and Berry Liqueurs
Authors: Гусейнова Батуч , Guseinova Batuch , Ашурбекова Фируза , Ashurbekova Firuza , Даудова Татьяна , Daudova Tatyana
Published: September 2019

Local vegetable raw materials have good prospects in developing new balanced foods with high nutrition value. As a rule, local vegetable raw materials are environmentally friendly and contain a wide range of biologically and physiologically active agents. Fruit liqueurs possess a balanced chemical composition and a high nutrition and physiological value. They produce a recreational or preventive effect on human organism. However, the level of consumption of fresh fruit and berries remains low because of their seasonality. Moreover, the range of fruit and berry products is usually very poor, and very few of them are beneficial for human health and can prevent diseases. The research featured the formulations and production technology for new multicomponent fruit liqueurs of high nutrition value. The liqueurs were made from Dagestan garden and wild fruit and berries with a high content of macro- and micronutrients. The nutrition value and quality of the liqueurs were estimated according to the mass concentration of sugars, titrable acids, vitamins C and P, β-carotene, mineral elements, and phenolic and pectinaceous substances. The sensory properties were measured according to a 10-score system. The paper introduces formulations and technologies for three types of liqueur (Zhivitel’naya, Garmoniya, and Uslada). They involved alcoholized and fermentation-alcoholized juices of grapes, fruit and berry fruit drinks and extracts that mutually complemented each other according to valuable components. The new liqueurs have a high nutrition since 100 cm3 of the liqueur per day partially satisfies the daily requirements for some nutrients: phenolic substances – for 37.5–55.0%; pectinaceous substances – 17.5–32.5%; in vitamin C – 13.7–38.7%, β-carotene – 17.6–43.0%, and a microelement iron – for 14.0–26.0%. The multicomponent fruit liqueurs possess a wide range of biologically and physiologically active agents. As a result, they improve physical activity and increase resistance to bad ecological environment.
Innovative controlling technologies
Authors: Бычкова Светлана , Bychkova Svetlana , Жидкова Елена , Zhidkova Elena , Андреева Олеся , Andreeva Olesya
Published: September 2019

Modern agro-industrial and food industry enterprises require continuous improvement of management systems. The complexity and specificity of the agro-industrial production determine the approaches and management methods, which have

to be innovative. The research objective was to examine the role of innovation in controlling, as well as innovative technologies of controlling that can improve management efficiency of food industry enterprises. The research was based on the neosystemic approach. This fundamental method of scientific knowledge was applied to all aspects of the innovative fundamental theory of agroindustrial complex organizations, the role of innovation in the controlling system, and innovative controlling technologies. According to the neosystemic approach, the controlling system was considered as a single system that consists of initial subsystems and uses knowledge and achievements of various fields of science to solve specific problems. As controlling implements the management process at agricultural enterprises, it means that relevant innovations should be developed in the field of agricultural enterprise management. To understand the role of innovation in the controlling system, the authors introduced the concept of ‘managerial innovation’. The choice of specific areas of managerial innovation in controlling should be based on the analysis of the external and internal environment, as well as on the strategic goals and objectives of the specific agricultural enterprise. In terms of its role and functionality, the controlling system is central to the management of the enterprise and, at the same time, has strong relationships with other systems and subsystems. Therefore, in order to select innovative technologies to be used in controlling, it is necessary to designate a range of tasks solved by the main elements of controlling. The paper describes the tasks of the main elements of

controlling. The authors suggest innovative management technologies that can be used in controlling in the context of the main management functions such as planning, accounting, monitoring, and analysis. The approach takes into account the system of goal setting and the decision-making process in food industry. Thus, the main task of the modern controlling system is to form management technologies that use innovation as an element of the management cycle. Innovative technologies can be used in controlling both to achieve a strategic goal and to move to a new level of enterprise development.
Letramentos acadêmicos na educação básica: perspectivas, pesquisas e possibilidades
Authors: Silva Jonathan Zotti da
Published: September 2019

Os estudos de letramentos acadêmicos se desenvolveram no contexto do ensino superior, principalmente devido às dificuldades de leitura e escrita dos estudantes que chegam à universidade. Este artigo tem o objetivo de discutir os letramentos acadêmicos na educação básica, descrevendo trajetórias e apontando para possibilidades de desenvolvimento do campo. Assim, são trazidas as perspectivas de alguns autores a respeito das práticas de letramento acadêmico no contexto da escola. Depois são apresentados estudos realizados em países da América do Norte e da Europa, que demonstram um campo de estudos bem estabelecido, ao passo que, ao relatar os estudos realizados no Brasil, percebe-se a incipiência do campo. Por fim, são apontadas algumas possibilidades de investigação para desenvolver os estudos de letramentos acadêmicos na educação básica, com destaque para a iniciação científica na escola e para as feiras de ciência.
Palavras-chave: Letramentos Acadêmicos; Educação Básica.
O letramento dos invisíveis: a operacionalização dos letramentos por adultos não alfabetizados
Authors: Ferreira Costa Kleber Ferreira , Rios Renata Ferreira , Lopes Wellington Moreira
Published: September 2019

Pegar o ônibus, ler a bula de remédio, acessar redes sociais são atividades corriqueiras no cotidiano de sujeitos letrados em nossa sociedade, mas para o adulto não alfabetizado essas e outras práticas sociais são vivenciadas com momentos de resistência e (re) construção do modo de agir diante do novo. Nesse contexto, este artigo tem por objetivo investigar que mecanismos de letramentos são acionados pelos adultos não alfabetizados em meio à sociedade grafocêntrica, que permite sua interação com os multiletramentos.  Esta pesquisa tomou por base os estudos de Soares (2005), Cavalcante Jr. (2009), Tfouni (2010), Bosi (2003) e outros, que a luz da abordagem qualitativa, de cunho exploratório nos levou a entender como adultos não alfabetizados operacionalizam os letramentos diversos em seu cotidiano.
PALAVRAS-CHAVE: Letramentos; Operacionalização; Adultos não-alfabetizados.
O lugar de J. Grimm no CLG
Authors: Rocha Raul de Carvalho , Faria Núbia Rabelo Bakker
Published: September 2019

No Curso de Linguística Geral (1916), F. de Saussure faz, ocasionalmente, referências explícitas aos primeiros linguistas alemães, em especial a Franz Bopp, responsável pela publicação, em 1816, da obra considerada o marco fundador dos estudos linguísticos propriamente ditos, na qual foram demonstradas as relações de parentesco entre línguas europeias e asiáticas. Jacob Grimm, a quem é atribuída a descoberta da primeira “lei fonética”, entretanto, é mencionado apenas em dois momentos, em um dos quais de forma crítica pela confusão entre letra e som presente em seu trabalho. Todavia, a importante descoberta de Grimm a respeito da mutação consonantal observada no gótico em relação ao grego, ao sânscrito e ao latim constituiu a base sobre a qual se fundamentaram os linguistas do último quartel do século XIX em seu redirecionamento dos estudos linguísticos para a fonética e para as “línguas vivas”. Pretende-se com esse trabalho discutir a importância de Grimm para o advento da Linguística Indo-Europeia e demonstrar a repercussão da descoberta do autor alemão sobre o estabelecimento da disciplina em sua época e sobre os autores posteriores, incluindo o próprio Saussure, com destaque para a separação entre os estudos sincrônicos e diacrônicos, apesar das parcas menções ao autor alemão no CLG, que sugeririam uma contribuição pífia de sua parte para o estudo científico da língua. Trata-se de uma pesquisa de natureza bibliográfica, fundamentada sobretudo em Auroux et al. (2000), Campbell (1999), Morpurgo Davies (1998; 2004) e Saussure (2012 [1916]).
A Moça Tecelã: uma análise semiótica do conto de Marina Colasanti
Authors: Fófano Clodoaldo Sanches , Souza Sonia Maria da Fonseca , Luquetti Eliana Crispim França
Published: September 2019

Esta pesquisa tem por objetivo refletir sobre a leitura como atividade de construção de sentido. Sendo assim, o texto não é visto como um objeto acabado, mas o sentido dele se completo no leitor, resultante de operações comunicativas e processos linguísticos sociocomunicativos. Como corpus para aplicação da teoria em estudo, escolheu-se o conto “A moça tecelã”, de Marina Colasanti que configura um texto de grande densidade significativa, permitindo o leitor contribuir para a tessitura do texto. Na construção deste artigo, realizou-se pesquisa bibliográfica de base qualitativa, considerando as contribuições de fontes teóricas que embasam a busca de respostas sobre o tema abordado. Portanto, a maneira na qual o autor constrói o texto pressupõe a participação do leitor na construção de sentido. O conto de Marina Colasanti ganha sentido e significação, não apenas como narrativa direcionada para um público infanto-juvenil, mas também para qualquer leitor ativo, participativo, capaz de alcançar informações implícitas presentes no texto, completando o sentido do texto, como coautor de um objeto inacabado. Assim, vale destacar que o cerne da produção de sentidos está na relação entre o dito e o compreendido.
Impeachment ou golpe? referenciação, orientação argumentativa e contexto em um debate da TV Folha
Authors: Antunes João Pedro Lobo , Miletta Martins Erik Fernando
Published: September 2019

Este trabalho apresenta uma breve análise dos processos de referenciação em um debate realizado pela TV Folha, canal de vídeos do jornal Folha de S. Paulo. Na ocasião, os convidados Guilherme Boulos (MTST) e Demétrio Magnoli (Instituto Millenium) discutiram, a partir de campos político-ideológicos opostos, a legitimidade ou não do processo de impeachment que resultou no afastamento da presidente Dilma Rousseff, dentre outros assuntos. Consideramos, neste trabalho, a referenciação como o processo intersubjetivo, discursivo e socialmente situado de construção dos objetos de discurso (MONDADA & DUBOIS, 2003). Assumindo esse posicionamento, partimos das estratégias de progressão referencial (KOCH, 2002) que emergem ao longo da interação entre os interlocutores do debate, assim como das duas dimensões constitutivas do contexto, emergência e incorporação (HANKS, 2008), para investigar como os interlocutores constroem, reconstroem e disputam os objetos de discurso em torno do evento impeachment, considerando os aspectos sociocognitivos dessa construção. O nosso objetivo é investigar, por meio de uma análise de cunho qualitativo, a construção da referência à luz do papel sociocognitivo do contexto, visando entender a relação entre esses processos na orientação argumentativa do debate. Pretendemos, por meio desta pesquisa, contribuir para a agenda sociocognitiva e para os estudos da referenciação em textos orais, além de de oferecer dimensões linguístico-textuais à discussão acerca do processo de aparente polarização que tem marcado a vida política brasileira nos últimos anos.
Estudo das construções condicionais em dois livros didáticos sob a perspectiva funcionalista
Authors: Petermann Rafael , Alves Rosangela Jovino
Published: September 2019

Os estudos funcionalistas têm por característica a análise dos elementos linguísticos a partir de seu contexto de uso, considerando a linguagem com um instrumento de interação social e que as estruturas gramaticais são motivadas pelo contexto comunicativo. Do mesmo modo, documentos norteadores do ensino de língua materna no Brasil, como os Parâmetros Curriculares Nacionais e as Diretrizes Curriculares para Educação Básica do Paraná também consideram que a interação é o que faz que a linguagem seja comunicativa, não sendo, por isso, possível que se estude uma língua isolada do ato comunicativo. A partir desse pressuposto, neste trabalho, apresentamos uma análise das construções condicionais em livros didáticos a fim de verificar se as definições e atividades apresentadas compreendem a concepção interacionista da linguagem e possibilitam uma reflexão dos elementos linguísticos em situações reais de uso. Este trabalho fundamenta-se na perspectiva teórica do funcionalismo, com ênfase nos trabalhos de Neves (1999; 2011), Castilho (2010) e Neves, Braga, Dall’Aglio-Hattnher (2008) sobre as construções condicionais.
A recategorização metafórica no debate político
Authors: Martins Santos Janyellen , Francisca Oliveira Santos Maria
Published: September 2019

Este trabalho analisa a atuação da recategorização metafórica na constituição da textualidade e da argumentação no gênero debate político. Esse processo referencial promove uma reconstrução dos objetos de discurso sob um âmbito mais complexo, por não se limitar às porções textuais e realizar-se, em geral, por anáforas indiretas sob a forma de uma metáfora. Em relação ao gênero debate político, ele é tido como um debate público e regrado e de base argumentativa, uma vez que nele os candidatos buscam convencer eleitores indecisos de que são os candidatos mais aptos para a presidência. O referencial teórico conta com as contribuições teóricas de Cavalcante, Custódio Filho e Brito (2014), Costa (2009), Custódio Filho (2011), Koch (2011), Koch e Elias (2015), Köche, Boff e Marinello (2010), Marcuschi (2003), Moreira (2002), Preti (2000) entre outros. O estudo segue uma abordagem qualitativa, segundo a qual foram analisados os dados da pesquisa de modo interpretativo, sem focalizar em sua quantificação. O corpus é constituído de fragmentos do debate da rede Band de televisão do segundo turno das eleições presidenciais no Brasil, em 2014. Em relação às análises, viu-se como a recategorização metafórica atuou na tessitura textual e na argumentação do debate político, promovendo não somente retomadas da realidade, mas também sua reelaboração, de forma negociada, segundo uma perspectiva sociocognitiva.

PALAVRAS-CHAVE: debate político; recategorização; referenciação
Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer
Authors: Dziobek Konrad , Opławski Marcin , Grabarek Beniamin O. , Zmarzły Nikola , Kieszkowski Przemysław , Januszyk Piotr , Kiełbasiński Kamil , Kiełbasiński Robert , Boroń Dariusz
Published: September 2019

Background:

Semaphorin 5A (SEMA5A) functions not only in the nervous system but also
in cancer transformation where its role has not yet been sufficiently studied and described.

Objective:

The aim of the study was to determine the changes in SEMA5A expression in endometrial
cancer at various degrees of its differentiation (G1-G3) compared to control.

Material and Methods:

The study group consisted of 45 patients with endometrial cancer at various
grades: G1, 17; G2, 15; G3, 13. The control consisted of 15 women without neoplastic changes in the
routine gynecological examination. The statistical analysis of immunohistochemical assessment of
SEMA5A level was carried out using the Statistica 12 program based on the Kruskal-Wallis test and
Dunn’s post-hoc test (p<0.05).

Results:

The expression of SEMA5A (optical density) was observed in the control group (Me =
103.43) and in the study group (G1, Me = 140.72; G2, Me = 150.88; G3, Me = 173.77). Differences in
expression between each grade and control and between individual grades turned out to be statistically
significant (p<0.01). The protein level of SEMA5A expression increased with the decreasing degree of
endometrial cancer differentiation.

Conclusions:

In our research, we indicated the overexpression of SEMA5A protein in endometrial cancer.
It is a valuable starting point for further consideration of the role of SEMA5A as a new supplementary
molecular marker in endometrial cancer.