bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Polymorphism on the Electrochemical Behavior of Dilithium (2,3-Dilithium-oxy)-terephthalate vs. Li
Authors: Bernard Lou , Jouhara Alia , Quarez Eric , Levieux-Souid Yanis , Le Caër Sophie , Tran-Van Pierre , Renault Stéven , Poizot Philippe
Published: May 2022

Organic electrode materials offer obvious opportunities to promote cost-effective and environmentally friendly rechargeable batteries. Over the last decade, tremendous progress has been made thanks to the use of molecular engineering focused on the tailoring of redox-active organic moieties. However, the electrochemical performance of organic host structures relies also on the crystal packing, like the inorganic counterparts, which calls for further efforts in terms of crystal chemistry to make a robust redox-active organic center electrochemically efficient in the solid state. Following our ongoing research aiming at elaborating lithiated organic cathode materials, we report herein on the impact of polymorphism on the electrochemical behavior of dilithium (2,3-dilithium-oxy-)terephthalate vs. Li. Having isolated dilithium (3-hydroxy-2-lithium-oxy)terephthalate through an incomplete acid-base neutralization reaction, its subsequent thermally induced decarboxylation mechanism led to the formation of a new polymorph of dilithium (2,3-dilithium-oxy-)terephthalate referred to as Li4-o-DHT (β-phase). This new phase is able to operate at 3.1 V vs. Li+/Li, which corresponds to a positive potential shift of +250 mV compared to the other polymorph formerly reported. Nevertheless, the overall electrochemical process characterized by a sluggish biphasic transition is impeded by a large polarization value limiting the recovered capacity upon cycling.
Effect of Pupal Cold Storage on Reproductive Performance of Microplitis manilae (Hymenoptera: Braconidae), a Larval Parasitoid of Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Xing Binglin , Yang Lei , Gulinuer Ahamaijiang , Li Fen , Wu Shaoying
Published: May 2022

As a major invasive pest in China, Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae) has caused great damage to crops. Hymenopteran parasitoids, especially the braconid wasps, play crucial roles in depressing pest populations. However, there was little information about the ideal storage of parasitoids to achieve their mass-rearing. Here, we identified a dominant parasitoid of S. frugiperda, Microplitis manilae (Ashmead) (Hymenoptera: Braconidae), in the Hainan province of China with a field parasitism rate of 5.66–19.10%. The investigation of biological parameters revealed that the parasitism rate of M. manilae significantly decreased with an increase in both wasp adult longevity and host age, and the wasp of 1–3 d post eclosion performed best on the first instar of host larvae, showing the highest parasitism rate. We also discovered that the decreased temperature from 30 to 20 °C greatly extended the longevity of wasp adults, and a similar result was observed after feeding on 10% sucrose water compared with sterile water. Then, the effects of different pupal cold storage temperatures (4 and 10 °C), storage period (prepupa, middle-aged pupa, late-aged pupa) and storage time (5, 10 or 20 d) on the emergence rate, parasitism rate, female proportion and longevity of M. manilae were investigated. The results demonstrated that the middle-aged wasp pupae stored at 10 °C for 5–10 d possessed a stronger parasitic ability and longer longevity. These findings may promote the flexibility and efficacy of large-scale production of M. manilae, thus contributing to its biological field control against S. frugiperda.
High Levels of Thromboxane (TX) Are Associated with the Sex-Dependent Non-Dipping Phenomenon in Ischemic Stroke Patients
Authors: Drozd Arleta , Szczuko Małgorzata , Bohatyrewicz Andrzej , Jurewicz Alina , Kotlęga Dariusz
Published: May 2022

Background: Inflammation and high blood pressure (nondipping profile) during the rest/sleep period have been associated with an effect on the incidence of cardiovascular disorders and a more severe course in the ischemic cerebrovascular event. There are no available data on the relationship between dipping status and the pro-inflammatory metabolites of arachidonic acid (AA); therefore, we undertook a study to investigate the influence of thromboxane on the incidence of nondipping among patients after stroke. Methods: Sixty-two patients with ischemic stroke (including 34 women and 28 men) were tested for the involvement of thromboxane in the nondipping phenomenon. Subjects were analyzed for the presence of the physiological phenomenon of dipping (DIP group) versus its absence—nondipping (NDIP group). Thromboxane (TX) measurements were performed using liquid chromatography, and blood pressure was measured 24 h a day in all subjects. Results: The analysis of the thromboxane level in the plasma of patients after ischemic stroke showed significant differences in terms of sex (p = 0.0004). Among women in both groups, the concentration of TX was high, while similar levels were observed in the group of men from the NDIP group. However, when comparing men in the DIP and NDIP groups, a lower TX level was noticeable in the DIP group. Conclusions: A higher level of TX may be associated with a disturbance of the physiological phenomenon of DIP in men and women. However, in our opinion, TX is not the main determinant of the DIP phenomenon and, at the same time, other pro-inflammatory factors may also be involved in the occurrence of this singularity.
The Effects of Dipeptidyl Peptidase 4 Inhibitors on Renal Function in Patients with Type 2 Diabetes Mellitus
Authors: Hsu Wan-Chia , Lin Chun-Sheng , Chen Jung-Fu , Chang Chih-Min
Published: May 2022

Past studies have confirmed that glucagon-like peptide 1 (GLP-1) receptor agonists can improve renal outcomes in patients with type 2 diabetes mellitus (DM). This study aimed to evaluate whether dipeptidyl peptidase 4 (DPP-4) inhibitors, which elevate GLP-1 levels, also have similar effects on renal function. In this retrospective study, diabetic patients treated with anti-hyperglycemic agents between 2008 and 2011 were selected. We compared the time to first occurrence of estimated glomerular filtration rate (eGFR) decline ≥30% from the baseline between patients treated with DPP-4 inhibitors and those treated with other anti-hyperglycemic drugs. A total of 2202 patients were enrolled. The incidence of eGFR decline ≥30% from the baseline was 10.08% in the DPP-4 inhibitor group and 16.17% in the non-DPP-4 inhibitor group (p < 0.001). The mean time to event was significantly longer in patients receiving DPP-4 inhibitors (2.84 ± 1.60 vs. 1.96 ± 1.30 years, p < 0.001). Patients who were younger than 65 years old, had better baseline eGFR, did not have preexisting hyperlipidemia, or who were untreated with concomitant statin showed greater reductions in the risk of renal function decline (all p for interaction < 0.05). Conclusively, DPP-4 inhibitors used alone or in combination with other glucose-lowering agents were correlated with lower risks of eGFR decline in patients with type 2 DM.
Sarcopenia and Myosteatosis Are Associated with Neutrophil to Lymphocyte Ratio but Not Glasgow Prognostic Score in Colorectal Cancer Patients
Authors: Aro Raila , Meriläinen Sanna , Sirniö Päivi , Väyrynen Juha P. , Pohjanen Vesa-Matti , Herzig Karl-Heinz , Rautio Tero T. , Mäkäräinen Elisa , Häivälä Reetta , Klintrup Kai , Mäkinen Markus J. , Saarnio Juha , Tuomisto Anne
Published: May 2022

Cancer patients commonly present sarcopenia, myosteatosis, and systemic inflammation, which are risk factors of poor survival. In this study, sarcopenia and myosteatosis were defined from preoperative body computed tomography scans of 222 colorectal cancer (CRC) patients and analyzed in relation to tumor and patient characteristics, markers of systemic inflammation (modified Glasgow prognostic score (mGPS), neutrophil–lymphocyte ratio (NLR), serum levels of C-reactive protein (CRP), albumin, and 13 cytokines, and survival. Of the systemic inflammation markers, sarcopenia and/or myosteatosis associated with elevated NLR (p = 0.005) and low albumin levels (≤35 g/L) (p = 0.018), but not with mGPS or serum cytokine levels. In addition, myosteatosis was associated with a proximal tumor location (p = 0.039), serrated tumor subtype (p < 0.001), and severe comorbidities (p = 0.004). Multivariable analyses revealed that severe comorbidities and serrated histology were independent predictors of myosteatosis, and older age and elevated NLR were independent indicators of sarcopenia. Myosteatosis associated with shorter overall survival in univariable analysis (HR 1.959, 95% CI 1.24–3.10, p = 0.004) but not in multivariable analysis (p = 0.075). We conclude that sarcopenia and myosteatosis were associated with inflammatory marker NLR, but not with mGPS. Moreover, patients with serrated CRC may have an increased risk of myosteatosis. Myosteatosis or sarcopenia were not independent predictors of patient survival.
Lifestyle Modification and Atrial Fibrillation: Critical Care for Successful Ablation
Authors: Fitzgerald John L. , Middeldorp Melissa E. , Gallagher Celine , Sanders Prashanthan
Published: May 2022

Management of atrial fibrillation (AF) requires a comprehensive approach due to the limited success of medical or procedural approaches in isolation. Multiple modifiable risk factors contribute to the development and progression of the underlying substrate, with a heightened risk of progression evident with inadequate risk factor management. With increased mortality, stroke, heart failure and healthcare utilisation linked to AF, international guidelines now strongly support risk factor modification as a critical pillar of AF care due to evidence demonstrating the efficacy of this approach. Effective lifestyle management is key to arrest and reverse the progression of AF, in addition to increasing the likelihood of freedom from arrhythmia following catheter ablation.
Use of Hyperoncotic Human Albumin Solution in Severe Traumatic Brain Injury Revisited—A Narrative Review and Meta-Analysis
Authors: Wiedermann Christian J.
Published: May 2022

A significant proportion of patients with a severe traumatic brain injury (TBI) have hypoalbuminemia and require fluid resuscitation. Intravenous fluids can have both favorable and unfavorable consequences because of the risk of hyperhydration and hypo- or hyperosmolar conditions, which may affect the outcome of a TBI. Fluid resuscitation with human albumin solution (HAS) corrects low serum albumin levels and aids in preserving euvolemia in non-brain-injured intensive care units and in perioperative patients. However, the use of HAS for TBI remains controversial. In patients with TBI, the infusion of hypooncotic (4%) HAS was associated with adverse outcomes. The side effects of 4% HAS and the safety and efficacy of hyperoncotic (20–25%) HAS used in the Lund concept of TBI treatment need further investigation. A nonsystematic review, including a meta-analysis of controlled clinical trials, was performed to evaluate hyperoncotic HAS in TBI treatment. For the meta-analysis, the MEDLINE and EMBASE Library databases, as well as journal contents and reference lists, were searched for pertinent articles up to March 2021. Four controlled clinical studies involving 320 patients were included. The first was a randomized trial. Among 165 patients treated with hyperoncotic HAS, according to the Lund concept, 24 (14.5%) died vs. 59 out of 155 control patients (38.1%). A Lund concept intervention using hyperoncotic HAS was associated with a significantly reduced mortality (p = 0.002). Evidence of the beneficial effects of fluid management with hyperoncotic HAS on mortality in patients with TBI is at a high risk of bias. Prospective randomized controlled trials are required, which could lead to changes in clinical practice recommendations for fluid management in patients with TBI.
Marginal versus Standard Donors in Heart Transplantation: Proper Selection Means Heart Transplant Benefit
Authors: Bifulco Olimpia , Bottio Tomaso , Caraffa Raphael , Carrozzini Massimiliano , Guariento Alvise , Bejko Jonida , Fedrigo Marny , Castellani Chiara , Toscano Giuseppe , Lorenzoni Giulia , Tarzia Vincenzo , Gregori Dario , Cardillo Massimo , Puoti Francesca , Feltrin Giuseppe , Angelini Annalisa , Gerosa Gino
Published: May 2022

Background: In this study, we assessed the mid-term outcomes of patients who received a heart donation from a marginal donor (MD), and compared them with those who received an organ from a standard donor (SD). Methods: All patients who underwent HTx between January 2012 and December 2020 were enrolled at a single institution. The primary endpoints were early and long-term survival of MD recipients. Risk factors for primary graft failure (PGF) and mortality in MD recipients were also analyzed. The secondary endpoint was the comparison of survival of MD versus SD recipients. Results: In total, 238 patients underwent HTx, 64 (26.9%) of whom received an organ from an MD. Hospital mortality in the MD recipient cohort was 23%, with an estimated 1 and 5-year survival of 70% (59.2–82.7) and 68.1% (57.1–81), respectively. A multivariate analysis in MD recipients showed that decreased renal function and increased inotropic support of recipients were associated with higher mortality (p = 0.04 and p = 0.03). Cold ischemic time (p = 0.03) and increased donor inotropic support (p = 0.04) were independent risk factors for PGF. Overall survival was higher in SD than MD (85% vs. 68% at 5 years, log-rank = 0.008). However, risk-adjusted mortality (p = 0.2) and 5-year conditional survival (log-rank = 0.6) were comparable. Conclusions: Selected MDs are a valuable resource for expanding the cardiac donor pool, showing promising results. The use of MDs after prolonged ischemic times, increased inotropic support of the MD or the recipient and decreased renal function are associated with worse outcomes.
Preoperative Anxiety in the Surgical Transfer and Waiting Area: A Cross-Sectional Mixed Method Study
Authors: Dziadzko Mikhail , Mazard Tessa , Bonhomme Myriam , Raffin Mahé , Pradat Pierre , Forcione Jean-Marc , Minjard Raphael , Aubrun Frederic
Published: May 2022

Severe preoperative anxiety (SPA) in surgical patients may have clinical consequences and worsen satisfaction. Some institutions have a surgical transfer and waiting area (TWA) for patient reception/dispatch to operating rooms. We measured the frequency of SPA, investigated predicting factors, and quantified the effect of the TWA stay on anxiety levels in a single centre cross-sectional study. Preoperative anxiety was assessed using three scales. Patients’ perceptions/suggestions were studied by a psychoanalyst. A total of 933 adult patients, undergoing elective procedures, were interviewed. SPA was detected in 24.7%, non-modified by anxiolytic premedication. Patients’ median stay was 9 min, and anxiety level was decreasing in those with SPA. In multivariable analysis, female sex, inpatient settings, and pain before the procedure were predictive for SPA. Previous operating room experience, and a supine arrival position were associated with less SPA. Patients complained about a lack of information, and an uncomfortable environment in the waiting area. To reduce anxiety, they mainly asked for warm blankets/music (physical/sound barriers), and extra sedative agents. The holding area may be a place to measure patients’ anxiety by paramedical staff, and to apply simple non-pharmacological interventions. The psychological concept of psychical envelopes may be useful for the development and investigation of such interventions in improving patients’ experience.
Wound-Related Complication in Growth-Friendly Spinal Surgeries for Early-Onset Scoliosis—Literature Review
Authors: Latalski Michał , Starobrat Grzegorz , Fatyga Marek , Sowa Ireneusz , Wójciak Magdalena , Wessely-Szponder Joanna , Dresler Sławomir , Danielewicz Anna
Published: May 2022

Background: The treatment for early-onset scoliosis (EOS) is one of the most challenging for pediatric orthopedics. Surgical treatment is often necessary, and wound problems and surgical site infections (SSIs) are common, with potentially severe complications in these patients. The aim of the study was to review current literature according to this complication. Methods: PubMed, Cochrane Library, and Embase were systematically searched for relevant articles by two independent reviewers in January 2022. Every step of the review was done according to PRISMA guidelines. Results: A total of 3579 articles were found. Twenty four articles were included in this systematic review after applying our inclusion and exclusion criteria. EOS surgery has a varying but high rate of wound-related problems (on average, 15.5%). Conclusion: The literature concerning the definitions, collection, and interpretation of data regarding EOS wound-related complications is often difficult to interpret. This causes problems in the comparison and analysis. Additionally, this observation indicates that data on the incidence of SSI may be underestimated. Awareness of the high rate of SSI of EOS surgery is crucial, and an optimal strategy for prevention should become a priority.
Relationship of Different Anthropometric Indices with Vascular Ageing in an Adult Population without Cardiovascular Disease—EVA Study
Authors: Gómez-Sánchez Leticia , Gómez-Sánchez Marta , Rodríguez-Sánchez Emiliano , Patino-Alonso Carmen , Alonso-Dominguez Rosario , Sanchez-Aguadero Natalia , Lugones-Sánchez Cristina , Llamas-Ramos Ines , García-Ortiz Luis , Gómez-Marcos Manuel A. ,   on behalf of the EVA Investigators
Published: May 2022

The objectives of this study were to analyse the capacity of different anthropometric indices to predict vascular ageing and this association in Spanish adult population without cardiovascular disease. A total of 501 individuals without cardiovascular disease residing in the capital of Salamanca (Spain) were selected (mean age: 55.9 years, 50.3% women), through stratified random sampling by age and sex. Starting from anthropometric measurements such as weight, height, and waist circumference, hip circumference, or biochemical parameters, we could estimate different indices that reflected general obesity, abdominal obesity, and body fat distribution. Arterial stiffness was evaluated by measuring carotid-femoral pulse wave velocity (cf-PWV) using a SphygmoCor® device. Vascular ageing was defined in three steps: Step 1: the participants with vascular injury were classified as early vascular ageing (EVA); Step 2: classification of the participants using the 10 and 90 percentiles of cf-PWV in the study population by age and sex in EVA, healthy vascular ageing (HVA) and normal vascular ageing (NVA); Step 3: re-classification of participants with arterial hypertension or type 2 diabetes mellitus included in HVA as NVA. The total prevalence of HVA and EVA was 8.4% and 21.4%, respectively. All the analysed anthropometric indices, except waist/hip ratio (WHpR), were associated with vascular ageing. Thus, as the values of the different anthropometric indices increase, the probability of being classified with NVA and as EVA increases. The capacity of the anthropometric indices to identify people with HVA showed values of area under the curve (AUC) ≥ 0.60. The capacity to identify people with EVA, in total, showed values of AUC between 0.55 and 0.60. In conclusion, as the values of the anthropometric indices increased, the probability that the subjects presented EVA increased. However, the relationship of the new anthropometric indices with vascular ageing was not stronger than that of traditional parameters. Therefore, BMI and WC can be considered to be the most useful indices in clinical practice to identify people with vascular ageing in the general population.
COVID-19 Vaccination in Inflammatory Bowel Disease (IBD)
Authors: Kubas Aleksandra , Malecka-Wojciesko Ewa
Published: May 2022

Vaccines against SARS-CoV-2 are believed to play a key role in the suppression of the COVID-19 pandemic. However, patients suffering from inflammatory bowel diseases (IBD) were excluded from SARS-CoV-2 vaccines trials. Therefore, concerns regarding vaccination efficacy and safety among those patients were raised. Overall, vaccination is well tolerated in the IBD population, and different gastroenterological societies recommend vaccinating patients with IBD at the earliest opportunity to do so. Nevertheless, very little is known about the safety of COVID-19 vaccines in special IBD populations such as pregnant and breastfeeding women or pediatric patients, and further research on this matter is crucial. The available data on vaccine efficacy are promising and show high seroconversion rates in IBD patients on different immune-modifying therapies. However, patients treated with high doses of systemic corticosteroids, infliximab or infliximab and immunomodulators may have a blunted response to the vaccination. The data on COVID-19 vaccination willingness among patients with IBD are conflicting. Nevertheless, vaccine effectiveness and safety are reported to be the most common reasons for hesitancy. This review examines the effectiveness and safety of COVID-19 vaccines and describes vaccination willingness and the reasons for potential hesitancy among patients with IBD.
Post Penetrating Keratoplasty Ectasia: Incidence, Risk Factors, Clinical Features, and Treatment Options
Authors: Moramarco Antonio , Gardini Lorenzo , Iannetta Danilo , Versura Piera , Fontana Luigi
Published: May 2022

BACKGROUND: Corneal transplantation in keratoconus (KC) patients is generally considered to be successful with a high grade of patient satisfaction. Long-term studies suggest a 6% to 11% probability of KC recurrence manifested by keratometric instability and progressive corneal ectasia. METHODS: We propose to review the frequency, risk factors for the development, and the surgical options for the correction of high irregular astigmatism due to late graft ectasia following penetrating keratoplasty (PK). RESULTS: Post-keratoplasty ectasia is characterized by increasing corneal steepening with myopic shift and high irregular astigmatism, developing years or decades after PK, mostly occurring in KC patients. Contact lenses may adequately improve the visual acuity; however, because these patients are often elderly and intolerant to hard contact lenses, ultimately a surgical correction is proposed to the patient. Compressive suture and corneal wedge resection may improve corneal astigmatism, but the outcomes are unpredictable and often temporary. For this reason, a larger PK graft is often proposed for surgical rehabilitation with the consequence of removing more of the recipient’s healthy endothelium and exposing the patient to a renewed immunogenic stimulus and short-term graft failure for endothelial decompensation. More recently, lamellar keratoplasty using various techniques has been proposed as an alternative to PK in order to maximize the visual outcomes and minimize the complications. CONCLUSIONS: Management of advanced corneal ectasia is a significant challenge for corneal surgeons. Many surgical approaches have been developed, so there is a large arsenal of surgical operations to correct post-PK ectasia. Among them, large-diameter anterior lamellar keratoplasty may be a viable, safer, and effective alternative to PK for the correction of post-keratoplasty ectasia.
COVID-19 and Autoimmune Liver Diseases
Authors: Floreani Annarosa , De Martin Sara
Published: May 2022

SARS-CoV-2 infection can trigger autoimmune responses, either by a systemic hyperstimulation of the immune system or molecular mimicry (or both). We here summarize the current knowledges about autoimmune liver diseases (AILDs) and COVID-19, focusing on (a) the risk of SARS-CoV-2 infection in patients affected by AILDs and/or under pharmacological treatment with immunosuppressants; (b) the capability of vaccination against SARS-CoV-2 to trigger autoimmune responses in the liver; and (c) the efficacy of vaccines against SARS-CoV-2 in patients with AILDs. Although unconclusive results have been obtained regarding the risk of being infected by SARS-CoV-2, generally indicating that all patients with chronic liver diseases have the same risk, irrespective of the etiology, the use of immunosuppressants in patients with AILDs seems to be correlated to COVID-19 severity. Few cases of autoimmune hepatitis (AIH) after SARS-CoV-2 vaccination have been reported, all characterized by a complete remission upon steroid treatment, but further evidence is needed to demonstrate the causality assessment. Humoral responses have been observed in patients with AILDs upon vaccination. In conclusion, the link between SARS-CoV-2 infection and AILDs is far to be completely elucidated. In these patients, the use of immunosuppressants has been correlated to an increase of disease severity and lower levels of antibodies upon vaccination.
Kinetic Gait Parameters in Unilateral Lower Limb Amputations and Normal Gait in Able-Bodied: Reference Values for Clinical Application
Authors: Schmid-Zalaudek Karin , Fischer Theresa , Száva Zoltán , Lackner Helmut Karl , Kropiunig Ursula , Bittner Christian , Höcker Karl , Winkler Günther , Peternell Gerfried
Published: May 2022

Unilateral lower limb amputations usually present with asymmetric interlimb gait patterns, in the long term leading to secondary physical conditions and carrying the risk of low physical activity and impairment of general health. To assess prosthetic fittings and rehabilitation measures, reference values for asymmetries as well as the most significant gait parameters are required. Kinetic gait data of 865 patients with unilateral lower limb amputations (hip and knee disarticulations, transfemoral, transtibial and foot amputations) and 216 able-bodied participants were quantitatively assessed by instrumented gait analyses. Characteristic spatiotemporal (stance time, walking speed, step length and width) and ground reaction force parameters (weight-acceptance and push-off peak) were contrasted to normal gait. All spatiotemporal and ground reaction force parameters differed significantly from normal gait with the largest differences in transfemoral amputations. These also differed between amputation levels and showed age-dependencies. The stance time and push-off peak difference were identified as the most discriminative parameters with the highest diagnostic specificity and sensitivity. The present results mark the first step to establishing universal reference values for gait parameters by means of which the quality and suitability of a prosthetic fitting and the rehabilitation progress can be assessed, and are generalizable for all adults with unilateral lower limb amputations in terms of level walking.
Risk Assessment of CHD Using Retinal Images with Machine Learning Approaches for People with Cardiometabolic Disorders
Authors: Qu Yimin , Lee Jack Jock-Wai , Zhuo Yuanyuan , Liu Shukai , Thomas Rebecca L. , Owens David R. , Zee Benny Chung-Ying
Published: May 2022

Background: Coronary heart disease (CHD) is the leading cause of death worldwide, constituting a growing health and social burden. People with cardiometabolic disorders are more likely to develop CHD. Retinal image analysis is a novel and noninvasive method to assess microvascular function. We aim to investigate whether retinal images can be used for CHD risk estimation for people with cardiometabolic disorders. Methods: We have conducted a case–control study at Shenzhen Traditional Chinese Medicine Hospital, where 188 CHD patients and 128 controls with cardiometabolic disorders were recruited. Retinal images were captured within two weeks of admission. The retinal characteristics were estimated by the automatic retinal imaging analysis (ARIA) algorithm. Risk estimation models were established for CHD patients using machine learning approaches. We divided CHD patients into a diabetes group and a non-diabetes group for sensitivity analysis. A ten-fold cross-validation method was used to validate the results. Results: The sensitivity and specificity were 81.3% and 88.3%, respectively, with an accuracy of 85.4% for CHD risk estimation. The risk estimation model for CHD with diabetes performed better than the model for CHD without diabetes. Conclusions: The ARIA algorithm can be used as a risk assessment tool for CHD for people with cardiometabolic disorders.
Anticoagulant Treatment in Severe ARDS COVID-19 Patients
Authors: Ceccato Adrian , Camprubí-Rimblas Marta , Campaña-Duel Elena , Areny-Balagueró Aina , Morales-Quinteros Luis , Artigas Antonio
Published: May 2022

Patients with COVID-19 may complicate their evolution with thromboembolic events. Incidence of thromboembolic complications are high and also, patients with the critically-ill disease showed evidence of microthrombi and microangiopathy in the lung probably due to endothelial damage by directly and indirectly injured endothelial and epithelial cells. Pulmonary embolism, deep venous thrombosis and arterial embolism were reported in patients with COVID-19, and several analytical abnormal coagulation parameters have been described as well. D-dimer, longer coagulation times and lower platelet counts have been associated with poor outcomes. The use of anticoagulation or high doses of prophylactic heparin is controversial. Despite the use of anticoagulation or high prophylactic dose of heparin have been associated with better outcomes in observational studies, only in patients with non-critically ill disease benefits for anticoagulation was observed. In critically-ill patient, anticoagulation was not associated with better outcomes. Other measures such as antiplatelet therapy, fibrinolytic therapy or nebulized anticoagulants are being studied in ongoing clinical trials.
An In Vitro and In Vivo Study of the Efficacy and Toxicity of Plant-Extract-Derived Silver Nanoparticles
Authors: Desai Anjana S. , Singh Akanksha , Edis Zehra , Haj Bloukh Samir , Shah Prasanna , Pandey Brajesh , Agrawal Namita , Bhagat Neeru
Published: May 2022

Silver nanoparticles (AgNPs) display unique plasmonic and antimicrobial properties, enabling them to be helpful in various industrial and consumer products. However, previous studies showed that the commercially acquired silver nanoparticles exhibit toxicity even in small doses. Hence, it was imperative to determine suitable synthesis techniques that are the most economical and least toxic to the environment and biological entities. Silver nanoparticles were synthesized using plant extracts and their physico-chemical properties were studied. A time-dependent in vitro study using HEK-293 cells and a dose-dependent in vivo study using a Drosophila model helped us to determine the correct synthesis routes. Through biological analyses, we found that silver nanoparticles’ cytotoxicity and wound-healing capacity depended on size, shape, and colloidal stability. Interestingly, we observed that out of all the synthesized AgNPs, the ones derived from the turmeric extract displayed excellent wound-healing capacity in the in vitro study. Furthermore, the same NPs exhibited the least toxic effects in an in vivo study of ingestion of these NPs enriched food in Drosophila, which showed no climbing disability in flies, even at a very high dose (250 mg/L) for 10 days. We propose that stabilizing agents played a superior role in establishing the bio-interaction of nanoparticles. Our study reported here verified that turmeric-extract-derived AgNPs displayed biocompatibility while exhibiting the least cytotoxicity.
Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers
Authors: Wang Zhe , Zhao Yili , Shen Mingwu , Tomás Helena , Zhou Benqing , Shi Xiangyang
Published: May 2022

Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT/DOX/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT/DOX/PLGA nanofibers, the designed organic–inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications.
Estimation of Pollutant Emissions and Environmental Costs Caused by Ships at Port: A Case Study of Busan Port
Authors: Yoo Yunja , Moon Beomsik , Kim Tae-Goun
Published: May 2022

To reduce air pollutants, the International Maritime Organisation and port authorities use ship emissions regulations, such as MARPOL Annex VI and green port policies. To measure the effectiveness of these air emissions regulatory policies, accurate calculations of pollutant emissions and estimations of the social environmental costs of emissions are important. However, Busan Port still suffers from a lack of research on continuous monitoring and easy access to data-based emission calculation methods and estimation of the social environmental costs. Therefore, the purpose of this study is to present quantitative emission calculations based on an open source and social environmental cost estimation method. To this end, the discharge of pollutants (NOx, SO2, CO2, VOC, PM2.5, and PM10) from ships in Busan Port was calculated using Port-MIS open data from 2015–2019. Subsequently, when the original study on estimating the social and environmental impact of air pollution from ships in Busan Port was difficult, the international benefit transfer method (an economic valuation method) was applied to estimate the social environmental costs. Our results can provide a basis for verifying the effectiveness of Busan Port’s air quality improvement policy in the future.
Deep Convolutional Gated Recurrent Unit Combined with Attention Mechanism to Classify Pre-Ictal from Interictal EEG with Minimized Number of Channels
Authors: Choi WooHyeok , Kim Min-Jee , Yum Mi-Sun , Jeong Dong-Hwa
Published: May 2022

The early prediction of epileptic seizures is important to provide appropriate treatment because it can notify clinicians in advance. Various EEG-based machine learning techniques have been used for automatic seizure classification based on subject-specific paradigms. However, because subject-specific models tend to perform poorly on new patient data, a generalized model with a cross-patient paradigm is necessary for building a robust seizure diagnosis system. In this study, we proposed a generalized model that combines one-dimensional convolutional layers (1D CNN), gated recurrent unit (GRU) layers, and attention mechanisms to classify preictal and interictal phases. When we trained this model with ten minutes of preictal data, the average accuracy over eight patients was 82.86%, with 80% sensitivity and 85.5% precision, outperforming other state-of-the-art models. In addition, we proposed a novel application of attention mechanisms for channel selection. The personalized model using three channels with the highest attention score from the generalized model performed better than when using the smallest attention score. Based on these results, we proposed a model for generalized seizure predictors and a seizure-monitoring system with a minimized number of EEG channels.
Development and Validation of Deep Learning-Based Algorithms for Predicting Lumbar Herniated Nucleus Pulposus Using Lumbar X-rays
Authors: Kim Jong-Ho , Lee So-Eun , Jung Hee-Sun , Shim Bo-Seok , Hou Jong-Uk , Kwon Young-Suk
Published: May 2022

Lumbar herniated nucleus pulposus (HNP) is difficult to diagnose using lumbar radiography. HNP is typically diagnosed using magnetic resonance imaging (MRI). This study developed and validated an artificial intelligence model that predicts lumbar HNP using lumbar radiography. A total of 180,271 lumbar radiographs were obtained from 34,661 patients in the form of lumbar X-ray and MRI images, which were matched together and labeled accordingly. The data were divided into a training set (31,149 patients and 162,257 images) and a test set (3512 patients and 18,014 images). Training data were used for learning using the EfficientNet-B5 model and four-fold cross-validation. The area under the curve (AUC) of the receiver operating characteristic (ROC) for the prediction of lumbar HNP was 0.73. The AUC of the ROC for predicting lumbar HNP in L (lumbar) 1-2, L2-3, L3-4, L4-5, and L5-S (sacrum)1 levels were 0.68, 0.68, 0.63, 0.67, and 0.72, respectively. Finally, an HNP prediction model was developed, although it requires further improvements.
Effect of Interactivity Level and Price on Online Purchase Intention
Authors: Summerlin Rowena , Powell Wendy
Published: May 2022

As e-commerce approaches 17% of total retail sales companies are looking for opportunities to increase customer purchase conversion. In a competitive marketplace it becomes increasingly important to consider the effects of display techniques on purchase intention. Limited research has been conducted into interactivity, product display and their effect on purchase intentions on real-world retail websites, predominantly choosing to use random or student samples. This study investigates whether interactivity within retail websites positively correlates with purchase intentions for both low-cost and high-cost products and whether this effect is proportionally higher in high-cost products. It considers whether this purchase intention in high-cost products is influenced by higher levels of supplementary information. 405 participants experienced a simulated environment within a real-world retail website they had previously shopped at. Questionnaire results were analysed using ANCOVA and principal components analysis with three new components (purchase intention, attitude towards products and repeat product enjoyment) emerging. Results showed a higher purchase intention for more interactive products particularly more expensive ones. Interactive products produced a 54% higher purchase intention overall. In this paper, a new three-component solution to assess purchase intention for online home décor products is presented along with results which indicate that interactivity levels positively affect purchase intention for this particular product segment, particularly higher-cost products.
Depth-to-Water Maps to Identify Soil Areas That Are Potentially Sensitive to Logging Disturbance: Initial Evaluations in the Mediterranean Forest Context
Authors: Latterini Francesco , Venanzi Rachele , Tocci Damiano , Picchio Rodolfo
Published: May 2022

Scientific research on reduced-impact logging has been addressed to develop effective approaches and methodologies to limit soil disturbance caused by forest operations. In recent years, the development of soil trafficability maps based on soil wetness indices is the approach that has been extensively used in the context of the Boreal forests. In particular, the depth-to-water (DTW) index has been identified as an interesting solution for the identification of areas particularly sensitive to soil disturbance. This study aimed to evaluate the cost-benefit factor of DTW maps for the identification of soil-sensitive areas in the Mediterranean context. In particular, a DTW map was developed for two oak coppice areas located in Italy and harvested over a period of 2–4 years with different mechanisation levels. Soil surveys concerning soil moisture, physico-chemical properties (bulk density, penetration resistance, shear resistance, organic matter), and biological properties (soil microarthropods community measure via soil biological quality (QBS-ar) index) were carried out in these forests, checking for significant differences between the zones at DTW index ≤1 (which should be more sensitive to soil disturbance) and the other areas of the forest soil. The results obtained revealed the efficiency of a DTW index in potential areas at a higher level of soil moisture. On the other hand, the values of soil physico-chemical properties in the areas at a DTW index ≤1 did not differ significantly from the ones in other zones. However, the values of the QBS-ar index in areas with a low DTW index were significantly lower than the ones in zones at the DTW index >1. Therefore, the obtained findings reveal that the DTW index is a reliable tool to identify and predict which areas are more prone to impact soil biological properties.
Multi-Time Scale Analysis of Urbanization in Urban Thermal Environment in Major Function-Oriented Zones at Landsat-Scale: A Case Study of Hefei City, China
Authors: Lu Yuting , Wu Penghai , Xu Kaijian
Published: May 2022

Urbanization and increasing demand for natural resources and land have affected the urban thermal environment. This is an important hot topic in urban climate research. In this study, we obtained multi-time scale land surface temperatures (LST) at the Landsat scale in Hefei, China, from 2011 to 2020. The evolution of the surface urban heat island (SUHI) was analyzed, and the contribution index (CI), urban thermal field variation index (UTFVI), and landscape pattern were evaluated to analyze the thermal environment mechanism of a major function-oriented zone (MFOZ). In addition, we explored the role and mechanism of different MFOZs in a thermal environment. Our results show that the multi-time scale differences in the SUHI were obvious, with the phenomenon of heat islands being concentrated in the main city zone. There are significant multi-time scale differences in the CI of different landscapes under the MFOZ. The UTFVI analysis of the MFOZ shows that the livability of the cities in the core optimization zone (COZ) and modern urbanization and industrialization cluster development zone (IDZ) is poor. MFOZ planning moderately alleviated the urban thermal environment of the entire study area, especially in the agricultural development zone (ADZ) and ecological conservation zone (ECZ). This study can guide the planning of the MFOZ and guide decision-makers in selecting governance zones when planning policies or dividing the key restoration areas of the thermal environment.
How Eco-Efficiency Is the Forestry Ecological Restoration Program? The Case of the Sloping Land Conversion Program in the Loess Plateau, China
Authors: Deng Yuanjie , Cai Wencong , Hou Mengyang , Zhang Xiaolong , Xu Shiyuan , Yao Nan , Guo Yajun , Li Hua , Yao Shunbo
Published: May 2022

The Forestry Ecological Restoration Program (FERP) aims to restore the world’s degraded forest landscapes to restore biodiversity and mitigate climate change. Scientific evaluation of eco-efficiency of forestry restoration programs (EEoFERPs) is the basis for developing and implementing inclusive and sustainable development policy measures. We take the world’s largest FERP—China’s Sloping Land Conversion Program (SLCP)—as an example. Using 314 county-level panel data in the Loess Plateau, the core area for the implementation of the SLCP, during 2002–2015, this study aims to evaluate the eco-efficiency of the Sloping Land Conversion Program (EEoSLCP) based on a DEA model and to measure the eco-efficiency dynamic changes through a Malmquist index model. The results show that: (1) The overall EEoSLCP of the Loess Plateau is at a low level, with an average efficiency of only 0.357 from 2002 to 2015. EEoSLCP is on an overall upward trend, mainly influenced by technical efficiency. (2) There are significant spatial differences in EEoSLCP among counties on the Loess Plateau, with an overall decreasing distribution trend from south to north and from southeast to northwest. (3) The Malmquist index of the EEoSLCP grew at an average annual rate of 17.7%, with technical efficiency changes being the most important factor driving its growth. Our results suggest that in the future, when implementing or designing FERPs, it is necessary not only to select the appropriate restoration plan precisely while respecting the laws of nature, but also to improve the management and technical level of FERPs accordingly.
A Plural Indefinite Article in Heritage Greek: The Role of Register
Authors: Alexiadou Artemis , Rizou Vasiliki , Karkaletsou Foteini
Published: May 2022

This paper investigates the use of kati “some” by Greek Heritage Speakers (HSs) in comparison to monolinguals. While all Greek determiners are marked for gender, case, and number, and agree with their nominal complement, kati is an exception, as it lacks agreement and combines only with plural nouns. Building on the existing literature, we show that its function is to remain vague about the number of individuals/entities denoted. Our hypothesis is that vague language (VL) is a feature of informal conversations and of the spoken language. To this end, we conducted a study in which Heritage Speakers of Greek and monolingual speakers of Greek participated in a production task held in two distinct settings and modalities. In addition, we performed corpus searches to see how both monolingual and Heritage Speakers use kati. The results show that monolingual speakers do indeed prefer kati in the informal register, while Heritage Speakers overgeneralize its use across registers. Our findings confirm the use of vague language in informal registers and oral modality and support claims in the literature on register levelling by Heritage Speakers. Focusing on monolinguals’ repertoire, a judgment task with different levels of formality was additionally performed. These results in principle align with our hypothesis and signal that neither frequency nor other informality contexts trigger a higher rate for kati.
The Acquisition of Negation in Italian
Authors: Tagliani Marta , Vender Maria , Melloni Chiara
Published: May 2022

The acquisition of negation in Child Italian has not yet been comprehensively addressed in the literature. This paper aims to provide a fine-grained picture of the acquisition process in this Romance language by considering production data and exploring three specific aspects of negation development: (a) the emergence and subsequent development of negators and negative constructions, (b) the acquisition of negative functions and their varying proportion of use and (c) the emergence of negative concord constructions. Using the CHILDES database, the longitudinal data of four monolingual Italian children for an observation period from 1;07 to 3;04 years of age were extracted, and the negative utterances attested in their speech production were analyzed for both the single- and the multiword utterance period. Results show a consistent and progressive form–function development of negation, mainly in line with previous cross-linguistic literature but with some language-related features. Minor differences across children are also attested, which are arguably related to their language development, as measured by their mean length of utterance (MLU) in the age intervals considered.
The Origin and Early Evolution of Life: (Prebiotic) Systems Chemistry Perspective
Authors: Altamura Emiliano , Fiore Michele
Published: May 2022

Aristotle considered that “nature does not do anything endless” [...]