bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment and quantification of average soil erosion using RUSLE and geospatial modeling for sustainable Land management over Melka-Sedi Catchment, Ethiopia.
Authors: Abera Bereket
Published: October 2024

Soil erosion is a significant worldwide threat, with far-reaching adverse effects on the environment. The general objective of this study is to assess the spatial average soil loss, identify high-risk areas, and visually represent variation of soil loss from Melka-sedi catchment employing Revised Universal Soil Loss Equation (RUSLE) and geospatial modeling. RUSLE computes average soil erosion based on five significant factors: rainfall erosivity, topography, cover management, soil erodibility, and support and management activities. The spatial distribution of all factors and the final RUSLE estimations were performed using the ArcGIS workspace. The results of this study indicated that the annual soil loss from the catchment ranged from 0 to 4,742 tons ha− 1 year− 1. The area was categorized into five subclasses of soil loss severity zones: high, sub-high, moderate, sub-low, and low. Most of the land, 209,561.24 hectares (77.25%), falls into the low erosion category, while 36,093.65 hectares (13.05%) are classified as sub-low erosion, 13,992.43 hectares (5.15%) are considered moderate erosion, 7,363.25 hectares (2.71%) as sub-high erosion, and 4,249.98 hectares (1.56%) as high erosion. Overall, the total annual soil loss throughout the study area was 1,098,931.5 tons. More than 4% of the land within a catchment requires urgent conservation activities. It is concluded that significant soil erosion is found in the catchment, and it is recommended to prioritize erosion-affected areas in the catchment and apply conservation practices to achieve sustainable watershed management within the catchment. This study provides useful information for directing actions to reduce erosion, prevent significant land degradation, and achieve sustainable land management.
Predicting MOOC Dropout Using Ensemble Models Based on RNN and GRU
Authors: Talebi Kowsar , Torabi Zeinab , Daneshpour Negin
Published: October 2024

Nowadays, dropout prediction in Massive Open Online Courses (MOOCs) has become a popular field in educational data mining. In order to predict early dropouts with high accuracy, this research introduces a model for data pre-processing. In addition, since our data consist of time series, Recurrent Neural Networks (RNNs) and Gated Recurrent Units (GRUs) are used. The study proposes six ensemble models named Adaboost RNN, Voting RNN, Bagging RNN, Adaboost GRU, Voting GRU, and Bagging GRU to improve the accuracy of dropout prediction. The models were trained and evaluated using KDD Cup 2015 data set. Results show that the ensemble models outperform both RNN and GRU models individually, with Bagging GRU achieving an accuracy of 91.73% and improving precision, recall, and F-score as well. The findings suggest that deep learning techniques such as RNN and GRU can be effective tools for predicting MOOC dropout rates, and that ensemble models can further enhance their predictive power.
Die Sonnentanz-Rituale der Cheyenne und Lakota-Sioux in Vergangenheit und Gegenwart als dynamische Prozesse
Authors:   , Röder Stefanie
Published: October 2024

Die Dissertation umfasst die Metaanalysen der Sonnentanz-Beschreibungen beider Ethnien von 1865 bis in die Gegenwart. Zu diesem Zweck wurde die historisch-kritische Methode, ethnohistorischer Manier, als eine Form der Metaanalyse verschiedenster Arten von Quellen angewendet. Die ergänzenden Inanspruchnahmen der Matrixanalyse nebst Ritualtheorien verdeutlichen, wie Individuen und Ethnien ihre Wirklichkeit konstruieren. Die Dissertation geht überdies der Hypothese nach, inwiefern die divergierenden Zeremonien als Sonnentänze zu definieren sind. Der Ritualvergleich hat das Ziel, die in diesem Zusammenhang wirkenden dynamischen sowie stabilen Dimensionen aufzuzeigen. Darüber hinaus werden die geschichtlichen Prozesse, die damit einhergingen, entfaltet und Begründungen für diese Entwicklungen herausgearbeitet.
The Analytical Performance Evaluation of Routine Clinical Chemistry Parameters by Six Sigma Approach: An Effective Tool for Laboratory Quality Management
Authors: Rasheed Asma , Sharif Sadia , Humayun Lubna , Javaid Faiza , Agha Muhammad Afaaq , Ilyas Anam , Tahir Naeem
Published: October 2024

Background: Clinical laboratories errors can impose serious adverse effects on patient management. Clinical laboratories can evaluate their analytical performance by effective quality management tool i.e. Six Sigma metrics.Objectives: To evaluate the analytical performance of routine chemistry parameters by Six Sigma approach.Methods: Cross sectional study carried out from July 2022 till February 2024 in the Chemical Pathology section of University of Lahore Diagnostic Lab and Research Center, Lahore. Analytical performance of nineteen routine chemistry parameters were evaluated by using the external and internal quality control material. Only those parameters were selected who enrolled in External Quality Assurance Scheme. Inclusion criteria for IQC following West gard rule +/- 2 SD while for EQAS results follow +/- 2 Z score. Sample size for 19 parameters analyzed in EQAS from July 2022 till December 2023 was 342. 2700 IQC samples were analyzed from August 2023 till February 2024. All control values were entered in Microsoft Excel 2013 and calculated manually by conventional equations.Results: Most of our laboratory parameters showed satisfactory analytical performance in between 3-6 when evaluated by six sigma metrics.Conclusion:  Control frequency for parameters showed score > 6 can be reduce for saving laboratory resources whereas parameters with sigma score around 3 needs more vigilant monitoring. Health care and laboratory outcome need high quality results to improve patient health. Six sigma tool allows laboratory to identify the right method, right rule, run controls at right frequency to enable the right patient outcome.
Stormwater runoff volume reduction and pollutant removal efficiency via bioretention cell using rock wool as the media
Authors: Qiu Rongting , Wang Jianlong , Qiu Zhiming , Wang Shiping , Yang Tao , Sun Jian , Tu Nannan
Published: October 2024

Bioretention cells have been widely used in stormwater management. Media plays an important role in stormwater runoff volume reduction and pollutant removal. A novel bioretention media of rock wool has been proposed, and its effect on stormwater runoff volume reduction was investigated via a laboratory-scale experiment. The results showed that compared with the conventional bioretention (CB) using medium sand as media, the volume capture ratio of annual rainfall (VCRAR) of the rock wool bioretention (RWB) was 2.66–5.5% higher, and the peak flow reduction rate was 2.97–11.32% higher. The removal efficiency of the RWB on COD, NH4+ -N, TN, and TP were 25–30%, 10–31%, 20–40%, and 5–14% higher than the CB, respectively. The removal efficiency of the RWB on both Pb and Zn was >99%. The microbial high-throughput sequencing results showed that the RWB can provide a better breeding environment for Bacteroides and Actinobacteria, which is conducive for the removal of pollutants. The RWB had a better stormwater runoff volume reduction rate and pollutant removal efficiency than the CB, therefore, it could be used as a better media for bioretention cells to improve stormwater management efficiency by using rock wool, obtained from construction waste, as the media.
Methylene blue adsorption by chemical-activated Trichanthera gigantea leaf
Authors: Fakunmoju Azeezat Ayoku , Azaman Fazureen , Ali Asmadi , Hamzah Sofiah
Published: October 2024

This study investigated the potential of NaOH-treated Trichanthera gigantea leaf (TGL) powder as a sustainable, low-cost biosorbent for methylene blue (MB) removal from wastewater. Characterization using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Brunauer–Emmett–Teller, and energy-dispersive X-ray spectroscopy (EDX) techniques confirmed favorable morphology, identifying micropores, suitable functional groups, notable surface area, pore volume, and elemental diversity. Batch experiments systematically investigated the influence of operational parameters, including contact time, initial MB concentration (5–35 mg/L), pH (2–10), and biosorbent dosage (2–10 g/L) on adsorption performance. The Langmuir isotherm model best represented the experimental data (R² values of 0.993 and 0.9725), indicating favorable adsorption (RL < 1) and maximum MB adsorption capacities of 0.822 and 0.330 mg/g for treated and untreated TGL, respectively. Statistical analysis (ANOVA) results further identified the most significant factors influencing MB biosorption. These findings highlight the potential of NaOH-treated TGL powder as an effective and eco-friendly solution for removing MB dye from industrial effluents, contributing to sustainable wastewater treatment and environmental protection.
Assessment of bioaccumulation and toxic effects of Cobalt (II) aluminate nanoparticles for hygienic safety purposes
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation, Zemlyanova M.A. ,   Perm State University, 15 Bukireva St., Perm, 614068, Russian Federation, Stepankov M.S. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation, Pustovalova O.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation, Nedoshitova A.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya St., Perm, 614045, Russian Federation
Published: October 2024

Hygienic safety plays an important role in preventing health harm under chemical exposures. Hygienic regulation of levels of existing and new substances in environmental objects is the core element here carried out within experimental research aimed at establishing their toxic properties. Cobalt (II) aluminate nanoparticles (CoAl2O4 NPs) are a typical example of a new material with presumably higher toxic potential upon oral exposure as opposed to micro-sized particles (MPs). Given that, the development of safety standards requires identifying features of the negative impact of CoAl2O4 NPs, which are different from MPs upon oral exposure. The study was performed on Wistar rats orally exposed to NPs and MPs for 20 days at the total dose of 10,550 mg/kg of body weight. NPs have chemical composition similar to MPs, smaller size (87.11 times) and larger specific surface area (1.74 times). NPs have a more pronounced ability to bioaccumulate in the heart, lungs, liver and kidneys as compared to MPs (up to 7.54 times). Exposure to NPs resulted in more pronounced (up to 3.60 times) changes in blood indicators associated with developing redox imbalance, cytotoxic effect, liver, pancreas and kidney dysfunction, inflammatory process, and thrombocytopenia. NPs caused hemorrhagic infarcts and pulmonary edema not established upon MPs exposures. The calculated value of the tentatively permissible exposure level (TPEL) was 0.02 mg/dm3 for these NPs content in drinking water, which is 10 times lower than the same value for MPs. Thus, CoAl2O4 NPs upon oral exposure for 20 days at the total dose of 10,550 mg/kg of body weight have more marked bioaccumulation relative to MPs, which causes more pronounced negative effects identified by changes in blood indicators and developing pathomorphological changes. The study findings allow increasing accuracy and objectivity when developing safety standards for CoAl2O4 levels in food products and drinking water to ensure greater hygienic safety of the population.
Unveiling the Power of Mitochondrial Fission and Fusion: A Five-Gene Signature for Personalized Prognosis in Gastric Cancer
Authors: Zhou Bin , Tie Ping , Li Dongbing , Lu You , Liu Yuanhua
Published: October 2024

Background:

Mitochondrial fission and fusion play important roles in tumorigenesis,
progression and therapy. Dysregulation of these processes may lead to tumor progression,
and regulation of these processes may provide novel strategies for cancer therapy. The involvement
of genes related to mitochondrial fission and fusion (MD) in gastric cancer (GC) remains
poorly understood.

Objective:

The aim of this study was to establish an MD gene signature for GC patients and to
investigate its association with prognosis, tumor microenvironment and treatment response in
GC.

Methods:

We use the TCGA-GC database as the cohort, focusing specifically on genes associated
with MD. We conducted identification and consistency clustering analysis of differentially
expressed genes in MD, conducted MD gene mutation and copy number variation analysis,
as well as correlation and functional enrichment analysis between MD gene cluster classification
and immune infiltration. TCGA-GC and GSE15459 were used to construct training and
validation cohorts for the model. We used various statistical methods, including Cox and Lasso
regression, to develop the model. We validated the model using bulk transcriptome and single-
cell transcriptome datasets (GSE13861, GSE26901, GSE66229, and GSE13450). We
used GSEA enrichment, CIBERSORT algorithm, ESTIMATE, and TIDE to gain insight into
the annotation of MD signature and the characterization of the tumor microenvironment. OncoPredict
was used to analyze the relationship between the PRG signature and the drug sensitivity.
We validated the expression of several key genes in MD signature on GC cell lines using
quantitative real-time PCR (qRT-PCR).

Conclusion:

The MD signature has the capacity to significantly contribute to the prediction of
personalized outcomes and the advancement of novel therapeutic strategies tailored for GC patients.

Results:

These MDs-related subtypes exhibited different prognosis and immune filtration patterns.
A five-gene signature, comprising AGT, HCFC1, KIFC3, NOX4, and RIN1, was developed.
There was a clear distinction in overall survival between low- and high-risk patients.
The analyses showed further confirmation of the independent prognostic value of the gene signature.
There was a notable correlation between the MD signature, immune infiltration and
drug susceptibility. The expression levels of AGT, HCFC1, KIFC3, NOX4 and RIN1 mRNA
were all increased in these GC cells.
125 Years of Aspirin: Status of Analytical Methods
Authors: dos Santos Galvao Natalia Sabina , Sinzervinch Aline , Lustosa Isadora Alves , Kogawa Ana Carolina
Published: October 2024

Aspirin, an analgesic, antipyretic and non-steroidal anti-inflammatory drug, was a fascinating discovery
that became the precursor to one of the oldest pharmaceutical success stories. It was discovered in
1899 by Felix Hoffman and patented in 1900. In 2024, Aspirin turns 125 years old and is still one of the bestselling
medicines today. This review aims to celebrate 125 years of Aspirin and show the status of analytical
methods available in the literature to evaluate pharmaceutical products based on Acetylsalicylic Acid (ASA).
In addition, it contextualizes them with the current needs of green and clean analytical chemistry. ASA, despite
being consolidated in the consumer market, embraces continuous improvement as it is a fundamental
part of studies for other new purposes and studies with associations with other active ingredients. In the manuscripts
available in the literature, ASA is predominantly evaluated by HPLC (41%) and UV-vis (41%) methods,
which use methanol (21.82%) and acetonitrile (18.18%), followed by buffer (16.36%). The most evaluated
pharmaceutical matrix is ASA tablets (40%), followed by ASA tablets in combination with other drugs
(26%). While ASA continues to innovate in the market through new forms of delivery and combinations, as
well as intended purposes, the analytical methods for evaluating its pharmaceutical products do not. They continue
with non-eco-efficient analytical options, which can significantly improve and meet the current demand
for green and sustainable analytical chemistry.
A Review on Nanotechnologically Derived Phytomedicines for the Treatment of Hepatocellular Carcinoma: Recent Advances in Molecular Mechanism and Drug Targeting
Authors: Sahu Chandrashekhar , Sahu Ram Kumar , Roy Amit
Published: October 2024

The second largest cause of cancer-related death worldwide, Hepatocellular Carcinoma
(HCC) is also the most common primary liver cancer. HCC typically arises in patients with liver
cirrhosis. Existing synthetic medicines for treating chronic liver disease are ineffective and come
with undesirable side effects. Although herbal remedies have widespread popularity, there is still a
long road ahead before they are fully accepted by the scientific community. Secondary metabolites
and phytochemicals found in plants are abundant in both the human diet and the non-human
environment. Natural plant chemicals have been shown to be beneficial as therapeutic and chemopreventive
treatments for a wide variety of chronic disorders. Many diseases, including HCC, can
be effectively treated with the help of phytochemicals found in food. Resveratrol, curcumin,
urolithin A, silibinin, quercetin, N-trans-feruloyl octopamine, emodin, lycopene, caffeine, and
phloretin are all examples. Approximately, 60% of all anticancer medications are determined to be
derived from natural substances, according to recent studies. Plant derivatives have played an important
role in cancer due to their capacity to scavenge free radicals, limit cell proliferation, and
set off apoptosis. The progression of HCC is linked to inflammatory signaling pathways, and this
study sought to look at how novel approaches, such as phytomedicines, are being used to fight cancer.
Recent advancements in molecular mechanisms and drug targeting for HCC have been discussed
in this review.
Intersecting Peptidomics and Bioactive Peptides in Drug Therapeutics
Authors: Balakrishnan Anagha , Mishra Saurav Kumar , Sharma Kanchan , Gaglani Chartha , Georrge John J.
Published: October 2024

Peptidomics is the study of total peptides that describe the functions, structures, and interactions
of peptides within living organisms. It comprises bioactive peptides derived naturally or synthetically
designed that exhibit various therapeutic properties against microbial infections, cancer
progression, inflammation, etc. With the current state of the art, Bioinformatics tools and techniques
help analyse large peptidomics data and predict peptide structure and functions. It also aids in designing
peptides with enhanced stability and efficacy. Peptidomics studies are gaining importance in
therapeutics as they offer increased target specificity with the least side effects. The molecular size
and flexibility of peptides make them a potential drug candidate for designing protein-protein interaction
inhibitors. These features increased their drug potency with the considerable increase in the
number of peptide drugs available in the market for various health commodities. The present review
extensively analyses the peptidomics field, focusing on different bioactive peptides and therapeutics,
such as anticancer peptide drugs. Further, the review provides comprehensive information on in silico
tools available for peptide research. The importance of personalised peptide medicines in disease
therapy is discussed along with the case study. Further, the major limitations of peptide drugs and the
different strategies to overcome those limitations are reviewed.
Evaluation of Anti-Proliferative and Apoptosis-Inducing Activities of the New Ciprofloxacin Derivative on Human Leukemia NB4 Cells
Authors: Goharkhany Selda , Eslami Farhad , Khalaj-Kondori Mohammad , Mahdavi Majid
Published: October 2024

Backgrounds::

Leukemic stem cells are considered to be the main cause of treatment
failure and disease recurrence due to their resistance to most common therapies. Apoptosis induction
is one of the highly effective methods for treating cancer. Ciprofloxacin is among the compounds
whose antitumor effects have been confirmed.

Objectives:

In this study, we investigated the anti-proliferative effect and induction of apoptosis by
one of the derivatives of this family called 1-Cyclopropyl-6-fluoro-7-[4-(2-{[(1R,2S,5R)- 2-
isopropyl-5-methylcyclohexyl]oxy}-2-oxoethyl)-piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-
carboxylic acid (ICH-CP) on NB4 cell line as an in vitro model of Acute promyelocytic leukemia
(APL). NB4 cells were treated using the ICH-CP combination in various concentrations.

Methods:

The viability of NB4 cells was evaluated by MTT assay, and their morphology of apoptosis
was examined by fluorescence microscopy. Flow cytometry and Annexin V/PI staining were
used to quantify apoptosis. Finally, the expression of three genes, Bax, Bcl-2, and Survivin was inquired
by real-time PCR.

Results:

According to the results, ICH-CP was able to destroy about 60% of NB4 cells in a dose
and time-dependent manner. Light microscopy and fluorescence microscopy studies on treated cells
confirmed the induction of apoptosis. Also, the real-time PCR analysis showed that ICH-CP induces
apoptosis in the NB4 cell line via the down-regulation of Survivin and Bcl-2, in contrast to the
up-regulation of the Bax gene.

Conclusion:

Based on the present data, it seems that the novel compound can be a good candidate
for the treatment of acute myeloid leukemia. Furthermore, it is recommended to evaluate the qualification
of ICH-CP as an adjunctive agent for other cancer cell lines.
Nano-reusable CuO-ZnO Catalyzed One-Pot Synthesis of 1-Amidoalkyl-2-Naphthols under Green Condition
Authors: Patil Gopinath G. , Muntode Bhausaheb B. , Jadhav Nitin K. , Dhere Vikram A. , Khabnadideh Soghra , Kale Raju R
Published: October 2024

Introduction:

The Developed CuO-ZnO nanocomposite has been demonstrated as a new
and environmentally friendly catalyst for one-pot multicomponent reaction between aldehydes, 2-
naphthol and amides in the synthesis of 1-amidoalkyl-2-naphthols.

Method:

The new catalyst was synthesized by a ball-milling method by mixing a mixture of CuO
and ZnO powder in various proportions and characterized by different spectroscopic methods such
as powder X-ray diffraction (pXRD), Scanning Electron Microscopy (SEM), UV-Visible analysis,
EDAX elemental analysis and mapping. The advantages of the devised protocol include a green
approach, simple work-up procedures, avoidance of hazardous solvents, and good to excellent
yields. RE

Sult:

Evaluation of the catalyst performance in the synthesis of some 1-amidoalkyl-2-naphthols
showed presentable results. Sixteen derivatives were synthesized in desirable yield by our new
method (4a-4p). CuO-ZnO nanocomposite as a safe and efficient catalyst could be reused up to 5
runs for the synthesis of naphthol derivatives without any significant decrease in its potency.

Conclusion:

The High purity of the products and desirable yields are other points that make the
present work more attractive.
Drivers of AI Adoption in Enterprises: A European-Wide Analysis
Authors: GUALANDRI Fabio
Published: October 2024

Abstract. Europe is one of the major global regions that has led the adoption of artificial intelligence (AI) in the corporate environment, leading to a significant shift in the technological and organizational landscape of the business world. As the continental economies are deeply embedded in economic and institutional layers, different factors might lead to higher AI adoption. This paper seeks to explore the factors that play a role in the diffusion of AI across various sectors and industries in Europe via quantitative statistical analysis of individual, corporate, and government-related variables. Results tend to indicate budget spending in research and development and digital intensity of companies as the most significant factors but assert that varied influences, not necessarily interrelated, can shape adoption patterns.
Navigating AI Regulation: A Comparative Analysis of EU and US Legal Frameworks
Authors: KUZIOR Aleksandra
Published: October 2024

Abstract. The rise of AI has led to significant changes in various industries, highlighting the need for strong regulations to ensure ethical and responsible AI development and implementation. This paper compares the European Union (EU) and the United States (US) regulatory strategies in addressing AI. As demonstrated by the comprehensive AI Act, the EU's proactive approach prioritizes transparency, accountability, and human-centered AI. At the same time, the US takes a more flexible approach by focusing on innovation through industry-specific guidelines and existing laws.
Development of interactive manipulative motion learning media using adobe animate for elementary school students
Authors: Lanos Muhsana El Cintami , Handyani Widya , Manullang Jujur Gunawan , Winartiningsih Anes , Festiawan Rifqi
Published: October 2024

Over the past few years, there has been a growing recognition of the importance of integrating technology into educational practices to engage students more effectively. Traditional PE methods and limited resources have hindered effective learning, necessitating new approaches. This research aimed to develop innovative, interactive learning media based on adobe animate to enhance elementary students’ learning outcomes in manipulative movement skills—a crucial component of Physical Education (PE) that fosters physical, social, emotional, and cognitive development. Utilizing the research and development (RD) method with Borg and Gall's ten-stage model, the study involved experts and participants from five elementary schools in Purwokerto City. Following a structured process of preliminary study, planning, development, field trials, product revisions, and large-scale testing, data were analyzed using SPSS software. Expert evaluations rated the media and material highly (91.25% and 87.50%, respectively), indicating strong acceptance and usability. Field trials showed increased student motivation and engagement, demonstrating the effectiveness of the interactive approach. Large-scale trials confirmed significant improvements in learning outcomes, with interactive media exhibiting greater efficacy compared to conventional methods. The paired sample t-tests revealed a statistically significant increase in learning outcomes, where Group A (utilizing interactive media) achieved a p-value of 0.001, whereas Group B (employing traditional methods) obtained a p-value of 0.040. The findings emphasize the critical role of incorporating innovative technologies like Adobe Animate in PE programs, offering a model for developing impactful learning media across diverse educational settings. Moreover, they stress the necessity for ongoing adaptation and feedback integration to sustain media relevance and effectiveness over time. Future research could investigate the long-term impacts of interactive media on varied subjects and learning environments, as well as explore possibilities for customizing instructional materials based on individual student needs.
Enhancing the accreditation of Indonesian private universities through the integration of EduQual and accreditation standards of the BAN-PT
Authors: Pratiwi Mirandhi , Kusumah Lien Herliani
Published: October 2024

Higher education institutions in Indonesia are currently facing significant challenges in maintaining public trust, requiring them to uphold autonomy, transparency, accountability, and continuously meet standards for quality assurance and improvement. This research aims to identify and address the unmet quality aspects in education to elevate the accreditation of private universities from C/Good to B/Very Good or even A/Excellent. By integrating the EduQual model with certification requirements from the Board of National Accreditation for Higher Education (Badan Akreditasi Nasional Perguruan Tinggi, BAN-PT), the research is supported by comprehensive studies of university accreditation reports, questionnaires, focus group discussions (FGD), and expert judgment through interviews and consultations. The data analysis employs gap analysis, importance-performance analysis, and quality function deployment. The study identified twenty-one priority improvement points to enhance accreditation, with six key improvements prioritized from the ninety indicators examined based on customer needs analysis.  In the accreditation of private universities, the unmet aspects of education quality lie in the dimension of physical facilities, particularly human resources, as well as in the dimension of personal development, especially in the criteria for research and community service. The study recommends prioritizing investments in human resource development and strengthening research and community service initiatives, as these are critical areas where private universities fall short in meeting accreditation standards and fulfilling educational quality expectations.
E-Screening for Prenatal Depression in Kampala, Uganda Using the Edinburgh Postnatal Depression Scale: Survey Results
Authors: Namatovu Hasifah Kasujja , Magumba Mark Abraham , Akena Dickens
Published: October 2024

Background

Perinatal depression remains a substantial public health challenge, often overlooked or incorrectly diagnosed in numerous low-income nations.

Objective

The goal of this study was to establish statistical baselines for the prevalence of perinatal depression in Kampala and understand its relationship with key demographic variables.

Methods

We employed an Android-based implementation of the Edinburgh Postnatal Depression Scale (EPDS) to survey 12,913 women recruited from 7 government health facilities located in Kampala, Uganda. We used the standard EPDS cutoff, which classifies women with total scores above 13 as possibly depressed and those below 13 as not depressed. The χ2 test of independence was used to determine the most influential categorical variables. We further analyzed the most influential categorical variable using odds ratios. For continuous variables such as age and the weeks of gestation, we performed a simple correlation analysis.

Results

We found that 21.5% (2783/12,913, 95% CI 20.8%‐22.3%) were possibly depressed. Respondents’ relationship category was found to be the most influential variable (χ21=806.9, P<.001; Cramer’s V=0.25), indicating a small effect size. Among quantitative variables, we found a weak negative correlation between respondents’ age and the total EPDS score (r=−0.11, P<.001). Similarly, a weak negative correlation was also observed between the total EPDS score and the number of previous children of the respondent (r=−0.07, P<.001). Moreover, a weak positive correlation was noted between weeks of gestation and the total EPDS score (r=0.02, P=.05)

Conclusions

This study shows that demographic factors such as spousal employment category, age, and relationship status have an influence on the respondents’ EPDS scores. These variables may serve as proxies for latent factors such as financial stability and emotional support.
Stunting Super App as an Effort Toward Stunting Management in Indonesia: Delphi and Pilot Study
Authors: Erika Kadek Ayu , Fadilah Nur , Latif Aulia Insani , Hasbiah Nurhikmawaty , Juliaty Aidah , Achmad Harun , Bustamin Anugrayani
Published: October 2024

Background

Currently, 30 million children are experiencing acute malnutrition, and 8 million children are severely underweight.

Objective

This study aimed to develop a stunting super app, a one-stop app designed to prevent and manage stunting in Indonesia.

Methods

This study consisted of three stages. Stage 1 used a 3-round Delphi study involving 12 experts. In stage 2, 4 experts and a parent of children with stunted growth created an Android app containing stunting educational materials. In stage 3, a pilot study involving a control group was conducted to evaluate parents’ knowledge about stunting prevention through the app and standard interventions.

Results

In the Delphi study, 11 consensus statements were extracted; arranged in three major themes, including maternal health education, child health education, and environmental education; and applied in the form of the Sistem Evaluasi Kesehatan Anak Tumbuh Ideal (SEHATI) app. This app was assessed using a content validity index, with a cumulative agreement of ≥80% among the 5 individuals. The pilot study showed an increase in the knowledge of mothers of toddlers with stunted growth before and after the educational intervention (P=.001).

Conclusions

The SEHATI app provides educational content on stunting prevention that can increase the knowledge of mothers of toddlers with stunted growth.
Identifying Patient-Reported Care Experiences in Free-Text Survey Comments: Topic Modeling Study
Authors: Steele Brian , Fairie Paul , Kemp Kyle , D'Souza Adam G , Wilms Matthias , Santana Maria Jose
Published: October 2024

Background

Patient-reported experience surveys allow administrators, clinicians, and researchers to quantify and improve health care by receiving feedback directly from patients. Existing research has focused primarily on quantitative analysis of survey items, but these measures may collect optional free-text comments. These comments can provide insights for health systems but may not be analyzed due to limited resources and the complexity of traditional textual analysis. However, advances in machine learning–based natural language processing provide opportunities to learn from this traditionally underused data source.

Objective

This study aimed to apply natural language processing to model topics found in free-text comments of patient-reported experience surveys.

Methods

Consumer Assessment of Healthcare Providers and Systems–derived patient experience surveys were collected and linked to administrative inpatient records by the provincial health services organization responsible for inpatient care. Unsupervised topic modeling with automated labeling was performed with BERTopic. Sentiment analysis was performed to further assist in topic description.

Results

Between April 2016 and February 2020, 43.4% (43,522/100,272) adult patients and 46.9% (3501/7464) pediatric caregivers included free-text responses on completed patient experience surveys. Topic models identified 86 topics among adult survey responses and 35 topics among pediatric responses that included elements of care not currently surveyed by existing questionnaires. Frequent topics were generally positive.

Conclusions

We found that with limited tuning, BERTopic identified care experience topics with interpretable automated labeling. Results are discussed in the context of person-centered care, patient safety, and health care quality improvement. Furthermore, we note the opportunity for the identification of temporal and site-specific trends as a method to identify patient care and safety concerns. As the use of patient experience measurement increases in health care, we discuss how machine learning can be leveraged to provide additional insight on patient experiences.
The Path of Breaking Out of the Circle for Prose Works in Film and Television as Seen from To the Wonder
Authors: Xiong Qiongyu
Published: October 2024

The TV series To the Wonder, adapted from a prose work, has garnered phenomenal attention with its high-quality content and poetic and healing style. The drama has achieved success in script adaptation by creating quality text content, and it has provided audiences with fresh aesthetic experiences by using visual language and poetic and scattered cultural narrative. At the same time, the content's dissemination and marketing are based on a multi-media matrix, with multi-channel dissemination, and it has explored a new path for diverse expression of prose works through the creation of IP-based derivative products in the film and television industry.
Epidemiological analysis of the mortality profile from Cerebrovascular Disorders in the Northern region of Brazil in the last decade
Authors: Leão Gabrielly Carvalho , Santos Vando Delgado de Souza , Vieira Dulce Karen Costa de Vasconcelos , Rabelo Israel Mariano , Silva Heitor Aécio Gonçalves da , Rodrigues Jhon Victor Bahia , Bahia Silene do Socorro Miranda , Moreira Caio Roberto Ramos , Ramos Suami Saminez Araújo , Costa Larissa Beatriz Pimentel , Silva Marília Leite da , Cavalcanti Moisés Soares , Baiana Gércia Espínola de Figueiredo , Costa Sebastiana Brandão da , Rizziolli Daniele Sutherland Wallauer , Braga João Lucas Watrin , Silva Letícia Adriane Medeiros da , Lima Beatriz Gobitsch Lopes de , Guajajara Elivanira Bento da Silva Rabêlo , Dillon Nicole Morais , Pedrosa Rakel de Moraes , Mesquita Bruna do Carmo , Santos Rafaella Casanova Ataíde dos , Rodrigues Diego Romani da Costa , Brasil Amanda Eduarda Vieira Carrera , Costa Eduarda Emilly Silva
Published: October 2024

Introduction: Cerebrovascular Diseases encompass several pathologies with clinical manifestations resulting from the interruption of cerebral blood flow, which can manifest in an ischemic form, generally linked to circulation obstruction, or in a hemorrhagic form, when there is vascular rupture. Given the widespread occurrence of deaths and permanent sequelae that such diseases generate, investigation and understanding of them become essential. Objectives: To analyze the epidemiological profile of hospital mortality due to Cerebrovascular Diseases in the northern region of Brazil, from January 2014 to December 2023. Methods: This is an observational and descriptive study, which provided records of deaths due to cerebrovascular diseases in individuals from the Northern region of Brazil, between January 2014 and December 2023, obtained through the Department of Informatics of the Unified Health System (DATASUS), using the variables color/race, age group and sex to define a mortality profile. Results: The data collected demonstrated the occurrence of 21,735 deaths due to cerebrovascular diseases in the region in question during the period considered, a value that corresponds to 6% of deaths nationally. Regarding the profile of these patients, it should be noted that 52.7% were male, 71.6% were over 60 years old and 60% declared themselves mixed race. Finally, 95% occurred urgently and 82% had their care regimen ignored. Conclusion: Thus, it is evident that cerebrovascular disorders predominate in the male population in a disadvantaged socioeconomic situation, especially elderly, brown men and possibly with restricted access to health surveillance and primary prevention mechanisms, such as encouraging and subsidizing healthy eating and physical activity. Therefore, the need for preventive actions is evident in order to guarantee the well-being and longevity of northern patients.
Antagonism activity of phosphate solubilizing microbes and nitrogen fixing bacteria toward Fusarium sp.
Authors: Fitriatin Betty Natalie , Dewi Yeni Wispa , Sofyan Emma Trinurani
Published: October 2024

The ability of phosphate solubilizing microbes and N-fixing bacteria as biofertilizers to increase growth and soil P-dissolve, N soil, they also have the potential to suppress disease, The purpose of this experiment to study antagonism activity of phosphate solubilizing microbes and N-fixing bacteria to inhibit pathogen isolate. In vitro antagonism test was carried out to test the ability of isolates biofertilizers as biocontrol The isolate of phosphate solubilizing microbes were Pseudomonas mallei, Pseudomonas cepacea, Bacilkussubtilis, Bacillus megaterium, Penicilliumsp.,and Aspergillusniger while the isolate ofN-fixing bacteria were (Azotobactervinelandii, Azotobacterchroococcum and Azospirillumsp. Fusarium sp. as pathogen was used for antagonism test. The experiment showed that phosphate solubilizing microbes and N-fixing bacteria have ability to inhibit growth of Fusariumsp. as pathogen. The results of the antagonism test of the biofertilizer isolates tested by Azospirillum were able to inhibit the growth of Fusariumsp. higher than other isolates.Furthermore, from this study it can be developed that biofertilizers are not only to increase soil nutrient availability and plant growth but can be used as biocontrol.
El panteón personal como una expresión de piedad popular y de sentido religioso en el pluralismo moderno
Authors: Núñez Hernández Rodolfo
Published: October 2024

Las prácticas religiosas individuales, en un contexto plural y moderno, asumen características que pueden ser interpretadas como expresiones de piedad popular. Estas prácticas reflejan un sistema personal de creencias que integra fórmulas y deidades, las cuales se estructuran en jerarquías y funcionalidad mediante soluciones de uso. Esto evidencia una autonomía en la creación y gestión de dichas creencias, prescindiendo de la intervención de agencias especializadas, como las iglesias oficiales. Tal dinámica supone un reto significativo para las organizaciones que buscan acompañar procesos formativos en el ámbito de la fe.
Diccionario del tseltal de Villa Las Rosas
Authors: Gómez López Tomás
Published: October 2024

Este es un diccionario dedicado a la compilación del léxico tseltal de Villa Las Rosas, una variante sureña en estado de obsolescencia. Incluye un prólogo (que corre a cargo de John B. Haviland), una introducción (en la que se tratan la situación actual de la lengua en cuestión, ciertas reflexiones metodológicas, así como la estructura general de la obra) y el diccionario como tal. Así pues, esa obra registra las palabras de esta variante del tseltal, acompañadas de una descripción pormenorizada del significado de los vocablos y de ejemplos de uso (con sus respectivas traducciones al español), e información adicional sobre morfología asociada, a fin de contribuir a la documentación de la lengua tseltal, entendida como la suma de todas sus variantes. Está dirigida principalmente a los propios usuarios de la lengua, si bien puede resultar igualmente útil para quienes desean analizarla o aprenderla.
Navigating Ethical Dilemmas: The Role of AI in Supply Chain Decision-Making
Authors: Chettiar Frania
Published: October 2024

Current times in which supply chains are increasingly viewed as being uncouth in the practice of their operations call for the integration of AI to thereby solve ethical dilemmas within such chains. This paper delves into the role played by AI to navigate ethical dilemmas in supply chains, thereby discussing its ability to resolve challenges such as labor rights, environmental sustainability, and responsible sourcing. Through this literature review, the current research is able to draw on existing work on AI applications within the supply chain and highlight gaps concerning ethical implications. The paper illustrates the real benefits and challenges surrounding the application of these technologies through case studies of those organizations which successfully implement AI-driven tools for ethical decision-making. The framework proposed should, therefore, bring about actionable recommendations to the business on attaining such a balance between operational efficiency and ethical responsibility. Lessons contained in the overall suggest the necessary use of AI to construct a more transparent and accountable supply chain landscape but lead to a more sustainable and ethically sound business landscape
Role of Inflammation and Motility Disorders in the Development, Course and Consequences of Functional Gastrointestinal and Biliary Tract Diseases (Literature Review and Expert Panel Resolution)
Authors: Ivashkin V. T. , Bordin D. S. , Lapina T. L. , Livzan M. A. , Okhlobystin A. V. , Poluektova E. A. , Trukhmanov A. S. , Uspenskiy Yu. P. , Shulpekova Yu. O.
Published: October 2024

Aim: to present the results of the Expert Panel with a discussion of modern concepts of the pathogenesis of functional gastrointestinal diseases and the possibilities of multitarget therapy with trimebutine.

   Key points. Low-grade inflammation can be considered as a morphological substrate of functional diseases with an increase in activated mastocytes and eosinophils, T-helpers 2 and T-helpers 17 in the gastrointestinal mucosa. In the development in the content of visceral hypersensitivity, the functional connection between mastocytes and TRPV1-positive sensory endings of the vagus nerve is of great importance. Proinflammatory cytokines and matrix metalloproteinases can enter the systemic circulation, provoking the development of systemic manifestations. Increased levels of proinflammatory cytokines are supported by altered intestinal permeability and microbiota. Functional diseases are believed to modify the symptoms and course of concomitant organic diseases of the gastrointestinal tract (for example, functional diseases of the biliary tract may contribute to the development of cholelithiasis, pancreatitis). The peripheral μ-, κ- and δ-receptor agonist trimebutine (Trimedat®) regulates the production of enterohormones, modulates motility throughout the gastrointestinal tract and normalizes visceral sensitivity. The effectiveness of trimebutine in the treatment of functional disorders has been shown in various studies. Trimebutine helps reduce the production of proinflammatory cytokines, including interleukin-6.

   Conclusion. In the treatment of functional diseases of the gastrointestinal tract, trimebutine can be considered as a multitarget agent, since the drug helps to normalize motility, reduces the degree of visceral hypersensitivity, exhibits anti-inflammatory and neuroregenerative effects, and can also increase the effectiveness of treatment of concomitant diseases.
Esophagoplasty Using a Jejunum Segment on a Vascular Pedicle
Authors: Ruchkin D. V. , Kozlov V. A. , Khamidov M. M. , Okonskaya D. E. , Kovalerova N. B.
Published: October 2024

Aim: to substantiate the expediency of using a segment of the jejunum on a vascular pedicle in esophagoplasty.

   Materials and methods. At the National Medical Research Center of Surgery named after A.V. Vishnevsky, 12 patients underwent esophagoplasty with a combined visceral transplant, of which 9 (75.0 %) received a gastrointestinal graft and 3 (25.0 %) — a colon-jejunum one. Esophagectomy with simultaneous esophageal plastic surgery was performed in 10 (83.3 %) patients, in 4 (40 %) of them — in combination with distal gastric resection. The indication for surgery in 3 patients was cicatricial stricture of the esophagus and stenosis of the pylorus, in 2 — achalasia of the cardia of the terminal stage (in one patient — with ulcerative stenosis of the pylorus). Three more patients underwent esophagectomy due to peptic strictures: esophagogastroanastomosis (n = 1), esophagoenteroanastomosis (n = 1) and esophagus after Nissen surgery (n = 1). Cancer recurrence after proximal gastric resection and gastrectomy in 2 patients was an indication for esophagectomy. Also, 2 (16.7 %) patients were hospitalized in the National Medical Research Center of Surgery named after A.V. Vishnevsky with incomplete esophagoplasty: one person — after Dobromyslov — Torek surgery for spontaneous rupture of the esophagus, and one patient — after the unsuccessful Lewis surgery for esophageal cancer performed in other hospitals.

   Results. The average duration of post-operative stay was 12.7 ± 6.3 days. The postoperative period was smooth in 10 (83.3 %) patients. The failure of the cervical anastomosis was revealed in 1 (8.3 %) patient on day 5 after esophageal plastic surgery with colon-jejunum graft, which was resolved conservatively without repeated surgery. Relaparotomy was required in one patient on day 7 after surgery for bile peritonitis, the cause of which was destructive acalculous cholecystitis with perforation. All 12 patients were discharged from the clinic with full nutrition through the mouth. In the long-term period, 11 (91.7 %) patients remained under observation, 1 (9.1 %) developed an esophagogastroanastomosis stricture 1.5 months after esophageal plastic surgery, which was resolved by 4 courses of bougation during the first 9 months after surgery. No other complications were noted.

   Conclusion. The segment of the jejunum on the vascular pedicle, used for esophagoplasty, in the condition of a shortage of plastic material, allows not only to complete the reconstruction at once, but also to restore the natural passage of food and prevent bile reflux.