bluuebunny/crossref_metadata_2025 huggingface dataset:
Studies on Smilax perfoliata and Breynia retusa against Experimentally Induced Cancer in Swiss Albino Mice
Authors: Begum Mariyam , Narasimha Kanjarla
Published: April 2024

The anticancer effect of methanolic extracts of Smilax perfoliata roots and Breynia retusa bark against Ehrlich ascites carcinoma (EAC) was investigated in the present study. The procured plant material was subjected to soxhlet extraction using methanol. Albino mice were divided into 7 groups of 6 mice (n = 6) in each group. Group I served as a control for about 14 days, and groups II to VII were administered EAC cells and the standard drug doxorubicin (0.3, i. p.) and test extracts at two doses 200 & 400 mg/kg daily. On last day of the experiment, mice were sacrificed for antitumor activity, tumor volume, cell viability, mean survival time and life span. Hematological and biochemical parameters were estimated. Liver sections were prepared and examined for histological changes. The antitumor effect of both the test extracts was dose-dependent. The volume of the tumor and cell viability were significantly reduced (**p < 0.001), whereas the mean survival time and life span were raised in a significant manner (**p < 0.001). The hematological parameters such as hemoglobin content, RBC, monocytes and lymphocytes were raised while WBC and neutrophils were reduced significantly (**p < 0.001) and the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (SALP), and bilirubin were reduced significantly after the treatment with the test drugs. Histopathological study revealed the restoration of the structure of the liver in the post-treatment animals. It was concluded that the methanolic extract of S. perfoliata roots and B. retusa bark exhibited antitumor activity, which might be due to the presence of alkaloids, glycosides, flavonoids, phytosterols, phenolic compounds phytosterols, carbohydrates and tannins. Further investigation of bioactive compounds is needed to confirm the anticancer properties thoroughly.
Apurinic Apyrimidinic Endonuclease 1 Gene Polymorphism Association with Total Antioxidant Level in Automobile Technicians
Authors: Mohammed Wathiq Kh , Muften Nafaa F , Toama Mariam A , Hadi Abas O , Hussai Kareem N , Ahmed Rathab A
Published: April 2024

The association of apurinic apyrimidinic endonuclease 1 (APE1) gene polymorphism with total antioxidant level in automobile technicians was proposed in the present study, using APE1 Asp148Glu (rs3136820) variation, reactive oxygen species (ROS) and total antioxidant levels (TAO) were depended in a case-control study, the results showed the mean of age (33.30 ± 1.94) years, body mass index (BMI) (26.19 ± 3.53) kg/m2 and work period (7.68 ± 4.9) years, the ROS level non-significant changes between cases and control (p 0.567) and significant elevation in TAO (p 0.000), The APE1 Asp148Glu (rs3136820) genotyping produced three genotypes (TT, GG and TG). The results of APE1 genotyping distribution showed non-significant association of Asp148Glu (rs3136820) with automobile technicians GG (p 0.8636), GT (p0.0718), also allele frequency didn’t associate with cases (p 0.8434), non-significant association of APE1 genotypes with smoker (p 0.1656), hookah (p 0.1001), alcohol uptake (p 0.8012) and chronic disease (p 0.6981), The ROS levels according to APE1 genotypes show non-significant variation (p 0.976) among genotypes. The TAO level according to APE1 genotypes showed significant differences among GG and TG in control group while significant elevation in TAO between TG genotypes in cases and control groups. The current study concluded that the APE1 gene polymorphism APE1 Asp148Glu didn’t associate with automobile technicians with long exposure to lead and cadmium, but it was associated with elevation in TAO level in workers
Method Development and Validation for Assay and Related Substance of Imatinib Mesilate in Bulk and Tablet Dosage form using RP-HPLC
Authors: Kshatriya Anand G , Andal P , Mhaske Ashok
Published: April 2024

A new method was developed and validated to assay imatinib mesilate and its impurities in drug substance and dosage forms. The developed method can be utilized to determine drug content and its related substances. The method validation study proves that the method is accurate, precise, specific and robust. The imatinib mesilate has five specified impurities and can be easily determined using this methodology. All impurities and imatinib peak are resolved using XB ridge C18, 250 mm x 4.6 mm, 5 μm column. A mixture of acetate buffer pH 9.5 and a mixture of methanol and acetonitrile in gradient mode are separated. The wavelength is selected at 264 nm with a column temperature of 30°C and a run time of 45 minutes. Linearity covered from 0.3 to 1985 μg/mL. The method has been validated as per ICH Q2 (R1) guidelines. Forced degradation study is performed using this method and proved that the method is stability-indicating and suitable for use.
Pharmacological Evaluation of Sedum lineare Thunb Extract: Acute Toxicity and Anticonvulsant Effects in Swiss Albino Mice
Authors: Kumar Sunil , Rawat AKS , Bhardwaj Peeyush
Published: April 2024

Aim: This study aimed to assess the acute toxicity and anticonvulsant effects of the hydroalcoholic extract of Sedum lineare Thunb in Swiss albino mice. Materials and Methods: Acute toxicity was evaluated by administering a high dose (2000 mg/kg) of the hydroalcoholic extract and monitoring mortality, behavioral changes, body weight, and food/water consumption. Hematological parameters and organ histopathology were analyzed to assess systemic effects. The anticonvulsant activity was explored using pentylenetetrazole (PTZ) and picrotoxin-induced seizure models at various extract doses (100, 250, and 500 mg/kg). Results and Discussion: The acute toxicity study revealed the safety of the hydroalcoholic extract, with no observed mortality, behavioral changes, or adverse effects on body weight and food/water consumption. While hematological changes were statistically significant, their clinical relevance requires further exploration. Histopathological examination confirmed the absence of organ toxicity. In the anticonvulsant assessment, the hydroalcoholic extract exhibited a protective effect against PTZ-induced seizures, significantly delaying jerk onset at the highest dose. Although not prevent clonic convulsions entirely, it dose-dependently reduces mortality rates. In the picrotoxin model, particularly at 250 mg/kg, the extract significantly increased clonic convulsion latency and suppressed mortality, indicating a potential modulatory role against seizures. Conclusion: The hydroalcoholic extract of S. lineare Thunb demonstrated favorable acute toxicity and promising anticonvulsant effects in Swiss albino mice. The observed hematological changes warrant further investigation for clinical relevance, and additional studies, including long-term assessments and biochemical analyses, are recommended to comprehensively evaluate the extract’s safety and therapeutic potential. These findings support further exploration of S. lineare Thunb as a potential candidate for neurological disorder interventions..
A Rapid, Selective and Sensitive Electrospray Ionization Assisted LC-MS Method for Ranolazine and Identification of Its Two Potential Genotoxic Impurities
Authors: RV Nagasurendra , N Devanna
Published: April 2024

A rapid, sensitive and selective electrospray ionization liquid chromatography-mass spectrometry (LC-MS) approach was developed to find and quantify the two genotoxic RANO contaminants (A and G) and forced degradation products of RANO in formulations of pharmaceutical drugs. X Select CSH C18 (100 x 3.0 mm, 2.5 μm) instrument was utilized for the separation with mobile phase containing of ammonia solution (A) and methanol (B) in gradient elution. About 254 nm as detection wavelength and 0.3 mL/min as flow rate were maintained. RANO has been degraded under stress conditions like thermal, oxidative, hydrolytic, peroxide, photolytic, acid and base, conditions. The resultant RANO products of degradation were well separated from RANO and its contaminants. Based on ICH rules the validation process was complying with the acceptance of precision, linearity, robustness and accuracy. To quantify the constituent contaminants (A and G), a positive electrospray ionization was connected to a triple quadrupole mass detector. The contaminants were determined in terms of LoD and LoQ values of 0.075 and 0.25 ppm, respectively, using the multiple reaction monitoring (MRM) mode.
Effect of NSAIDs in the Tooth Movement in Orthodontic Treatment
Authors: Dhayanidhi Aparnna , Nagella Sai P , Rai Narendra P , Chandrashekhar Kelkar K , Manivannan Prathap C , Arsheed Noor AA
Published: April 2024

Background: Patients undergoing tooth movement in orthodontics often utilize non-steroidal anti-inflammatory medications (NSAIDs) to alleviate inflammation and discomfort. On the other hand, the orthodontic profession is still debating whether or not NSAIDs slow down or hinder tooth mobility. Materials and Methods: About 60 mouths that needed their teeth moved participated in a randomized controlled experiment. There were two groups of patients: Group A received NSAIDs (ibuprofen, 400 mg), while group B received a placebo. Tooth movement was measured using digital calipers at baseline and then at intervals of 4 weeks over a period of 12 weeks. Results: The mean rate of tooth movement in group A was 1.5 ± 0.3 mm per month, whereas in group B it was 1.8 ± 0.4 mm per month. Analysis of variance (ANOVA) showed a statistically significant difference (p < 0.05) in the rate of tooth movement between the two groups, with group B demonstrating faster tooth movement compared to group A. Conclusion: The administration of NSAIDs during orthodontic treatment appears to have a modest but statistically significant inhibitory effect on the rate of tooth movement. Clinicians should consider the potential impact of NSAIDs on treatment outcomes when managing pain and inflammation in orthodontic patients.
Precision Medicine in Psychotherapy: The Past, Present and Future
Authors: Sukumaran Bhavatharini , SM Sharumathi , Xavier Rinu M , KP Arun , M Deepalakshmi
Published: April 2024

Precision medicine has sparked a fierce debate about the pros and cons of a more individualized healthcare strategy. Advances in precision medicine have challenged traditional paradigms of healthcare decision-making. Pharmacogenomics is part of precision medicine. Although genetic testing in drug therapy is still a relatively recent development, it is growing rapidly. Pharmacogenetic tests reveal genetic biomarkers that indicate a person’s drug susceptibility. They are increasingly being used to improve medication adherence; however, their utility in older people with polypharmacy remains to be well-studied. Mental illness is a major public health problem at both the individual and societal levels. Despite advances in psychopharmacology and better knowledge of therapeutic principles, there is still a long way to go to incorporate pharmacogenetic and pharmacogenomic research into psychiatry’s clinical practice. Numerous genetic variants have been associated with anti-psychiatric responses and adverse effects of treatment. The aim of this review is to summarise responses to psychotropic drugs in the context of pharmacogenetic polymorphisms.
Applications of Hafnium and other Transition Metals in Medicine – A Review
Authors: Rajaraman Vaishnavi , Ariga Padma , Sekaran Saravanan , Ganapathy Dhanraj , Veeraiyan Deepak N
Published: April 2024

Transition metals in the periodic table have been used in biological systems naturally. Synthetically, many materials have been used in the field of prosthodontics for the replacement of missing teeth. The research on these materials originally began from titanium which belongs to group 4 of the transition elements in the periodic table. Titanium has also established itself as the gold standard in prosthodontic and orthopedic replacements. After titanium, zirconium and hafnium were explored for the same purpose and till date researchers have been working on its feasibility. Extending this research, various metal options were studied by multiple biomaterial companies and researchers. Hafnium in the periodic table, which belongs to the group 4 elements, was also explored sufficiently. Nanoparticles are proven to have properties like strength, being lighter and cleaner, and contributing to smarter surface systems. This property has led to great contributions in the field of biomedical research and biomaterial development. Due to increased awareness of nanoparticles, metal nanoparticles are extensively studied for various biomedical applications. At the nanoscale, the properties of particles may change in unpredictable ways. This review highlights the use of transition metals in biology, including emphasis on the metal nanoparticles for biomedical applications.
Silver Nanoparticles as Antimicrobial Agents: Mechanisms, Challenges, and Applications
Authors: Yadav Jyoti , Tare Harshal
Published: April 2024

Silver nanoparticles (AgNPs) have garnered considerable attention for their potent antimicrobial properties and broad spectrum of applications in various fields. This review delves into the multifaceted realm of AgNPs as antimicrobial agents, aiming to provide a comprehensive understanding of their mechanisms of action, challenges, and diverse applications. The article begins by tracing the historical significance of silver as an antimicrobial agents and transitions into the contemporary role of AgNPs in modern applications. The synthesis of AgNPs is explored, encompassing diverse methods such as chemical, physical, and biological approaches. Particular emphasis is placed on green synthesis methods, which not only yield nanoparticles with controlled properties but also align with principles of environmental sustainability and biocompatibility. The review subsequently dissects the intricate mechanisms underpinning AgNPs antimicrobial process. The interaction of AgNPs with microbial cell membranes, generation of reactive oxygen species (ROS), and disruption of vital microbial processes collectively contribute to their potent bactericidal and fungicidal activities. However, the incorporation of AgNPs into various applications is not devoid of challenges. This article examines potential toxicity concerns, addressing issues related to stability, aggregation, and controlled release of nanoparticles, as well as the emergence of resistance mechanisms in microorganisms. Delving into the realm of applications, the review unveils AgNPs’ significance in biomedical and clinical settings, where they are employed in wound healing, medical devices, and infection control. Moreover, the environmental implications of AgNPs are explored, including their use in water and air purification, as well as potential roles in food and agricultural sectors. Looking forward, the review discusses emerging trends and suggests future research directions. Combinational therapies, integration with advanced materials, and exploration of AgNPs’ potential in addressing global antimicrobial resistance are outlined as promising avenues. In conclusion, this comprehensive review underscores the vital role of silver nanoparticles as versatile and potent antimicrobial agents, shedding light on their mechanisms, challenges, and multifarious applications across diverse sectors.
Benzimidazoles in Medicinal Chemistry: Current Trends and Future Opportunities
Authors: Kumawat Deepak , Tare Harshal
Published: April 2024

Because of their various pharmacological actions and structural plasticity, benzimidazoles, a class of heterocyclic molecules, have received much attention in medicinal chemistry. This review paper aims to provide a complete overview of the current developments and future possibilities of benzimidazoles as promising candidates for the creation of innovative therapeutic medicines. The introduction discusses the importance of benzimidazoles in medicinal chemistry, emphasizing their wide range of uses, which include antibacterial, anticancer, and central nervous system actions. The structural properties of benzimidazoles and the effect of substituent changes on their biological activity are investigated, as well as crucial structure-activity relationship (SAR) investigations. The review looks into the synthesis of benzimidazole derivatives, including both traditional and novel methods. The rise of microwave-assisted synthesis, green chemistry methodologies, and solid phase strategies for chemical manufacturing are explored. A thorough review of current breakthroughs in benzimidazole medicinal chemistry emphasizes the importance of target-based drug design, high throughput screening, and computational approaches in expediting drug discovery. As prospective directions for future research, the numerous applications of benzimidazoles in personalized medicine, nanotechnology-assisted medication delivery, and the examination of natural sources for chemical discovery are noted. However, concerns about toxicity, pharmacokinetic limits, and intellectual property difficulties have been raised, leading a cautious assessment of benzimidazole-based therapies. Benzimidazoles, medicinal chemistry, pharmacological activities, synthesis methodologies, structure-activity connection, drug discovery, and future possibilities are some of the keywords used in this study.
Construction and validation of an audio-visual tool to instruct caregivers of patients with pemphigus in photographing skin and oral cavity lesions during tele-consultation: A cross-sectional study
Authors: Prarthana Thammannagowda , Handa Sanjeev , Goel Sonu , Mahajan Rahul , De Dipankar
Published: April 2024

Background

Owing to the lack of standardised audio-visual (A-V) instructions to take photographs, patients with pemphigus faced difficulties during tele-consultation in COVID-19 pandemic.

Objective

To construct and validate an A-V instruction tool to take photographs of skin and oral cavity lesions of pemphigus.

Methods

In this observational study, we included patients with pemphigus of either gender seeking tele-consultation, aged 18 years or older. A-V instructions demonstrating skin and oral cavity photography were designed and shared with the patients. They were requested to send pictures of lesions that complied with the instructions. They were then required to complete a 10-item questionnaire for face validation in the two following rounds. The videos were content validated by 14 experts in the field of clinical dermatology.

Results

Forty-eight patients took part in face validation. A majority of patients, 47 (97.9%) and 45 (93.8%); rated the audio and video quality as being above average, respectively. Forty-seven patients (97.9%) said the instructional videos were useful, and 42 patients (87.5%) said they did not need to take any further images to show how severe their disease was. The average scale content validity index for the instructions on skin imaging and the oral cavity imaging during round 1 of content validation was 0.863 and 0.836, respectively.

Limitation

Validated instruction videos are in Hindi language and need to be further translated and validated in other local languages for use in non-Hindi speaking regions.

Conclusion

A-V instructions were useful to take photographs during tele-consultation.
Efektivitas Pregnancy e-Conseling terhadap Perilaku Kesehatan Maternal Selama Masa Pandemic Covid-19
Authors: Mira Rizkia  , Halifah Elka , Ardhia Dara , Darmawati Darmawati , Martina Martina
Published: April 2024

Mayoritas ibu hamil pada masa pandemi covid-19 enggan melakukan pemeriksaan kehamilan karena takut terpapar virus, sehingga konseling online menjadi alternatif. Tujuan dari penelitian ini adalah untuk mengidentifikasi efektivitas Pregnancy e-Counselling (PeC) terhadap perilaku kesehatan prenatal selama kehamilan selama masa Covid-19. Penelitian ini merupakan penelitian eksperimen semu dengan Pre-Post Test With Control Group Design. Teknik pengambilan sampel adalah simple random sampling pada 94 responden yang dibagi 47 ibu hamil pada kelompok kontrol dan 47 pada kelompok intervensi di 6 Puskesmas di Aceh Besar. Intervensi PeC diawali dengan Focus Group Discussion (FGD) dilanjutkan dengan konseling online yang dipandu oleh konselor disertai dengan pemberian video yang dirancang khusus tentang kesehatan ibu hamil selama masa Covid-19. Instrumen yang digunakan adalah kuesioner standar Prenatal Health Behavior Scale (PHBS). Hasil penelitian menunjukkan perbedaan yang signifikan antara perilaku kesehatan prenatal sebelum dan sesudah PeC pada kelompok intervensi dengan Uji Wilcoxon (p=0,000), dan pada post-test antara kontrol dan intervensi Mann-Whitney Test (p=0,000). Kesimpulan: PeC merupakan metode yang sangat efektif untuk meningkatkan perilaku kesehatan ibu selama kehamilan terutama pada masa pandemi. Sehingga sangat disarankan agar PeC dapat diterapkan sebagai bagian dari kunjungan kehamilan untuk meningkatkan kesehatan prenatal.
Pendugaan Umur Simpan Nupate (Nugget Patin Tempe) Menggunakan Metode ASLT (Accelerated Shelf Life Test) dengan Pendekatan Arrhenius
Authors: Atasasih Hesti , Paramita Irma Susan , Rahayu Dewi
Published: April 2024

Nugget ikan patin merupakan bentuk olahan dari ikan yang digiling halus, dicampur dengan bahan  pengikat ditambahkan bumbu lalu dikukus dan dicetak.12 Nugget sering ditambahkan bahan pangan lain untuk menambah nilai gizi salah satunya dengan tempe. Kandungan gizi pada ikan patin dan tempe diharapkan dapat mencukupi kebutuhan asupan gizi khususnya  protein,  sehingga dapat menjadi alternatif makanan olahan yang bergizi tinggi, namun terdapat permasalahan dalam pemanfaatannya yaitu kedua bahan pangan tersebut mudah rusak, sehingga agar tetap tersedia di masyarakat dapat dibuat menjadi makanan olahan. salah satu cara untuk melihat mutu makanan adalah dengan menghitung umur  simpan. Penelitian bertujuan untuk   menduga  umur simpan Nupate  (Nugget Patin Tempe) menggunakan metode ASLT,dengan pendekatan Arhennius.  Titik kritis yang digunakan adalah kadar air. Penelitian dilakukan di Laboratorium terpadu Poltekkes Kemenkres Riau. Hasil penelitian menunjukkan formula terpilih adalah P3,  kemudian dilakukan pengujian kadar air menggunakan termografimetri. Hasil pengukuran  kadar air adalah  40,43% yang berarti telah memenuhi persyaratan SNI 7758:2013, yaitu kurang dari 60%, kemudian di simpan  pada suhu -5, suhu – 10 dan suhu -15, Kadar air dipengaruhi oleh suhu, dengan bertambah tinggi suhu maka akan bertambah tinggi kadar air dan begitu juga  sebaliknya, suhu penyimpanan rendah, kadar air juga akan rendah.  . Umur simpan pada -5 adalah 4 Bulan, -10 6 bulan dan -15 8 Bulan. Saran penelitian adalah  dilakukan uji mikrobiologi,kimia dan proses pengemasan serta pelebelan.
Theoretical and legal characteristics of personal funds
Authors: Egorova U. P. , Kulichkin A. T.
Published: April 2024

With the introduction of the concept of “personal fund” in the legal field of the Russian Federation, a transformation of the fund institution as a whole has taken place. In the article, mostly by comparison, the authors analyze and characterizes a personal fund in a theoretical and legal aspect and highlights its differences from other funds, examining in detail the legal structure of a personal fund, its features and regulation. In particular, the article highlights the issue that a personal fund is a non-profit organization that manages the property of an individual. At the same time, its main function and goal is not solving social problems to support society, which has always been inherent in publicly beneficial funds.  A personal fund, rather, can be characterized as a new form of the hereditary fund that preceded it, but valid during the lifetime of the founder. The author, relying on the work of modern researchers, draws attention to a number of points that can be considered problematic from the point of view of legal regulation, which will require further elaboration of the law, on the basis of which the conditions for creating personal funds appeared in Russia.
On the 300th anniversary of the Russian Academy of Sciences: NEFU Academicians
Authors: Atlasova S. S.
Published: April 2024

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Interdisciplinarité et recherche opérationnelle sur le paysage
Authors: Thierry Brossard , François Chambaud , Daniel Joly , Elisabeth Lemaire
Published: April 2024

Le paysage constitue une entrée privilégiée pour aborder des domaines d’application variés relevant du développement durable. A ce titre, la présente recherche, qui s’intéresse aux rapports entre paysage et biodiversité, s'inscrit dans le cadre d'une opération agri-environnementale concernant le pays d’Apance-Amance (Haute-Marne). L'objectif visé est d’identifier et de cartographier différentes unités ornitho-écologiques dont la typologie a été définie après prospection de terrain. Celle-ci a autorisé l’identification d’un certain nombre de critères paysagers distinctifs de chacun des types reconnus. On a ensuite établi une correspondance entre les critères en question et certaines informations contenues dans un système d’information géographique (SIG). Informations tirées principalement d'images satellites et d'un modèle numérique de terrain. La formalisation des liens entre observations au sol et base d'informations numériques a donné lieu à l'élaboration d'un opérateur cartographique qui permet de circonscrire l'espace paysager potentiellement favorable aux unités ornitho-écologiques reconnues.
L’approche sémiologique au service de la mise en évidence du lien produit agricole – paysage
Authors: Michelin Yves
Published: April 2024

On utilise fréquemment le paysage comme preuve de la qualité et de l’attachement d’un produit agricole à son territoire de production mais souvent, les images utilisées pour la promotion de ces produits, présentent des paysages en décalage, parfois même en opposition avec ceux perceptibles dans l’aire de production. A partir d’une analyse sémiologique du paysage, nous avons construit une méthode participative de discussion de ce lien produit-paysage à destination des agriculteurs concernés et expérimenté celle-ci auprès de producteurs de l’AOC saint-nectaire. Les résultats positifs obtenus permettent de préciser la nature du lien sémiologique qui existe entre un produit et les paysages de sa zone de production et ouvrent des perspectives pratiques pour faciliter la négociation lors de l’élaboration ou le renouvellement du cahier des charges de produits d’origine garantie.
Entre le paysage-existence et le paysage-expérience, le paysage-itinérance
Authors: Griselin Madeleine , Nageleisen Sébastien , Ormaux Serge
Published: April 2024

La véritable offre de paysage n’est pas liée à un espace aréolaire, isotrope et statique mais elle se déploie le plus souvent dans la pratique du déplacement, de l’itinérance. Certes le choix d’un trajet et d’un mode de déplacement est déjà le résultat d’une projection du sujet à travers ses représentations et ses expérience sensibles antérieures, mais il apparaît que même déterminé par l’expérience, l’exercice du déplacement va filtrer fortement les conditions de conversion du paysage-géographie en paysage-expérience.Depuis plus de trente ans, sous la houlette de Jean-Claude Wieber, les géographes bisontins, ont développé une approche systématique de l’analyse paysagère d’entités surfaciques. Depuis quelques années, certains d’entre eux se sont penchés plus spécifiquement sur l’évaluation des paysages au long d’entités linéaires, en se plaçant dans la situation de leurs utilisateurs potentiels.Pour caractériser le paysage au long d’itinéraires, il convient d’avoir un regard d’ensemble, le moins subjectif possible, tout en réduisant la somme d'informations pour alléger les traitements. Nous illustrerons ici la démarche à travers l’exemple du chemin de Saint-Jacques entre Besançon et Compostelle, pour lequel nous tenterons également l’évaluation d’une certaine sensibilité des utilisateurs au paysage.
Faire corps avec le paysage
Authors: Collot Michel
Published: April 2024

Pour beaucoup de pratiques artistiques et poétiques contemporaines, le paysage est lié à un état du corps autant qu’à un état de l’âme. Cette incarnation du paysage correspond à l’importance croissante du rôle reconnu et dévolu au corps dans l’art et la littérature contemporaines. Mais cette valorisation de l’expression corporelle peut s’orienter selon deux directions divergentes. La poésie contemporaine peut faire ainsi du corps l'instrument d'une rupture avec l'idéalisme supposé de la tradition poétique et dresse le corps contre l'esprit ; valorisant l’in-sensé et l’im-monde, elle fait alors un usage critique et ironique du paysage. Mais elle peut aussi faire du corps un carrefour entre la matière et l'esprit, le sujet et le monde ; elle trouve alors dans le paysage un lieu privilégié où renouer l’unité du sens et du sensible. C’est cette seconde tendance, qui vise à faire corps avec le paysage, que M. Collot éclaire à l’aide de la phénoménologie et illustre d’exemples empruntés notamment à Valéry, Artaud et Gaspar.
KEMAMPUAN PEMAHAMAN KONSEP MATEMATIKA SISWA TERHADAP MATERI HIMPUNAN DI KELAS VII
Authors: Wahyuni Selly , Hartoyo Agung , Suratman Dede
Published: April 2024

This study aims to understand the obstacles of seventh grade students of SMP Negeri 1 Jawai Selatan in understanding numerical ideas on set material in class VII SMP Negeri 1 Jawai Selatan. The subjects in this study were students of class VII A SMP Negeri 1 Jawai Selatan which amounted to 31 students. Taking class VII as the subject depends on the approval of the school and the replacement students have gotten the material set at the junior high school level. The object of consideration is the test scores. Negeri 1 Jawa Selatan. In general, students' ability to understand numerical ideas in set material is at a moderate level, and this implies that students currently have a fairly good understanding of set material. The highest capacity is at the pointer of repeating set ideas with a level of 74% which is in the high classification, and it indicates that understudies can repeat the idea, while the lowest capacity is at the pointer of creating basic or adequate conditions with a level of 18% which is in the low classification, and it indicates that not many understudies can create basic or adequate conditions. In general, the ability of understudies to understand numerical ideas in set material is in the medium classification with a level of 47.5%.
PENGARUH MULTIMEDIA PEMBELAJARAN MATEMATIKA BERBASIS GOOGLE SITES TERHADAP MOTIVASI BELAJAR
Authors: Prayoga Ananda , Yusmin Edy , Munaldus Munaldus , Jamiah Yulis , Siregar Nurfadilah
Published: April 2024

In this study, researchers used Pre-Experimental Design with the form of One Group Pretest-Posttest Design. the sample in this study were 32 students of class XI TITL at SMK Negeri 2 Pontianak. the data collection technique in this study was an indirect communication technique using a questionnaire. The learning motivation of students who do not use multimedia martematics learning based on google sites has an average percentage of 71% (high). The learning motivation of students who use multimedia learning martematics based on google sites has an average percentage of 82% (very high). The effect of using multimedia learning martematics based on google sites on the learning motivation of class XI students at SMK Negeri 2 Pontianak is evidenced by the results of the Wilcoxon test whose probability value or Sig. 2 tailed of 0.000 <0.05 and an effect size value of 1.021 which shows an increase in learning motivation in the large category. Thus it can be concluded that the use of multimedia learning martematics based on google sites has a major effect on student learning motivation.
ETNOMATEMATIKA PADA KERAJINAN ANYAMAN TIKAR PANDAN
Authors: Mauliyana Hely , Rustam Rustam , Sayu Silvia
Published: April 2024

Mathematics lessons are considered abstract lessons far from everyday life. Therefore, the task of mathematics teachers is to present mathematical concepts in students' lives to mathematics learning. Ethnomathematics is an approach that links mathematics and culture. The method used is to explore the concept of ethnomathematics, one of which is in the craft of woven pandan mats as a student learning resource. The aim of this research is to describe the mathematical concepts contained in woven pandan mats in the Padang Tikar community and to use them as a mathematics learning resource in the form of LKPD. The form of research used in this research is exploratory research with an ethnographic approach. The subjects in this research were pandan mat craftsmen. The instruments used were observation guidelines and interview sheets. The data analysis technique used in this research is the Miles and Huberman model of data analysis. The results of the research show that there are several activities of woven pandan mat craftsmen, namely: determining which pandan is suitable for use, determining the length of the pandan, cleaning and determining the width of the ilik, boiling the ilik, soaking the ilik, drying the ilik, dyeing the ilik, making woven motifs, and determining the length and width pandan mat. The mathematical concepts contained are: sets, logic, comparison, multiples, fold symmetry, geometry, multiplication of integers, and measurement. From the mathematical concepts obtained, it will be used as a LKPD, namely geometry where the material taken is squares and rectangles.
Application of Digital Occlusion Analysis System in Stomatological Clinical Medicine
Authors:   Liu, DA Gu , LY Miao ,   Department of Cariology and Endodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China, C Liu ,   Liu
Published: April 2024

T-Scan III system is one of the most commonly used tools to analyze the bite forces simultaneously on the teeth. As the effectiveness and reliability of T-Scan III are widely studied and recognized, it has many clinical applications in dentistry for the evaluation of dental occlusion in the past decades, such as prosthodontics, orthodontics, and other subjects related to occlusion. This paper reviews the applications of T-Scan III in oral clinic in the past 10 years, and looks forward to its development and application in the future.
Assimilating an Enantiopure Supramolecular Nanocage from Achi-ral Building Blocks: The Impact of Chiral Recognition and Spin-crossover
Authors: PAUL ABHIK , Singh Misthi , Konar Sanjit
Published: April 2024

Chiral recognition and discrimination are not only of significance in nature’s intricate biochemical processes but also, at the supramolecular level, have proved to aid the understanding and exploration of chirality and their effects in sensing, molecular separation, and so on. Herein, we discuss the coordination-driven self-assembly to fabricate an enantioselective tetra-hedral nanocage with a general formula MII4L4 (MOC-1, M = Zn, Fe) starting from achiral building blocks. Systematic employment of tris-(4-aminophenyl)triazine (TzTa) with hydrogen bonding acceptor sites as triazine core and 2-butyl-5-chloro-imidazole-4-carboxaldehyde results in a racemic mixture of two enantiomeric cages (Td1), while the absence of such chirality directing groups (Td0), or hydrogen bonding acceptor sites (Td2) assimilates as a dynamic mixture of multiple stereoisomers. Interestingly, the compelling interplay of hydrogen bonding presented by R- or S-Binol as a chiral bias during the subcomponent self-assembly of Td1 induced the selective formation of a single enan-tiopure cage MOC-1Zn(R/S) via “reverse chiral recognition”, where the ultimate stereochemistry of the cage is deter-mined by the guest (Binol). Furthermore, subsequent replacement of the ZnII vertices of MOC-1Zn(R/S) by FeII ions al-lows the straightforward imprinting of a given stereochemistry in MOC-1Fe(R/S), unlike the racemization occurred by the subcomponent self-assembly (Fe4AS). The effective stereochemical coupling between the Binol and enantiopure MOC-1Fe(R/S) dictates the effective spin-state stabilization of the host and, thus, their magnetic responses. This exciting feature opens a new paradigm to associate the spin-crossover phenomenon with supramolecular chirality.
Molecular Beam Scattering from Flat Jets of Liquid Dodecane and Water
Authors: Yang Walt , Foreman Madison , Saric Steven , Wodtke Alec , Wilson Kevin , Neumark Daniel
Published: April 2024

Molecular beam experiments in which gas molecules are scattered from liquids provide detailed, microscopic perspectives on the gas–liquid interface. Extending these methods to volatile liquids while maintaining the ability to measure product energy and angular distributions presents a significant challenge. The incorporation of flat liquid jets into molecular beam scattering experiments in our laboratory has allowed us to demonstrate their utility in uncovering dynamics in this complex chemical environment. Here, we summarize recent work on the evaporation and scattering of Ne, CD4, ND3, and D2O from a dodecane flat liquid jet and present first results on the evaporation and scattering of Ar from a cold salty water jet. In the evaporation experiments, Maxwell–Boltzmann flux distributions with a cosθ angular distribution are observed. Scattering experiments reveal both impulsive scattering and trapping followed by thermal desorption. Super-specular scattering is observed for all four species scattered from dodecane and is attributed to anisotropic momentum transfer to the liquid surface. In the impulsive scattering channel, rotational excitation of the polyatomic scatterers is a significant energy sink, and these species accommodate more readily on the dodecane surface compared to Ne. Our preliminary results on cold salty water jets suggest that Ar atoms undergo vapor-phase collisions when evaporating from the liquid surface. Initial scattering experiments characterize the mechanisms of Ar interacting with an aqueous jet, allowing for comparison to dodecane systems.
Machine Learning in Complex Organic Mixtures: Applying Domain Knowledge Allows for Meaningful Performance with Small Datasets.
Authors: Le Katelyn , Radović Jagoš R. , MacCallum Justin L. , Larter Stephen R. , Van Humbeck Jeffrey F.
Published: April 2024

The ability to quantify individual components of complex mixtures is a challenge found throughout the life and physical sciences. An improved capacity to generate large datasets along with the uptake of machine-learning (ML) based analysis tools has allowed for various ‘omics’ disciplines to realize exceptional advances. Other areas of chemistry that deal with complex mixtures often cannot leverage these advances. Environmental samples, for example, can be more difficult to access and the resulting small datasets are less appropriate for unconstrained ML approaches. Herein, we present an approach to address this latter issue. Using a very small environmental dataset—35 high-resolution mass spectra gathered from various solvent extractions of Canadian petroleum fractions—we show that the application of specific domain knowledge can lead to ML models with notable performance.
The fabrication of Ti3C2 and Ti3CN MXenes by electrochemical etching
Authors: Chan Kai Chio , Guan Xiang , Zhang Teng , Lin Kailing , Huang Yihe , Lei Lingshu , Georgantas Yiannis , Gogotsi Yury , Bissett Mark A. , Kinloch Ian
Published: April 2024

2D MXenes are well-known for their outstanding performance in electrochemical energy storage and many other applications owing to their high conductivity and specific surface area. An obstacle to the wider synthesis of MXenes for research and industrial applications is the use of hazardous hydrofluoric acid (HF) during their synthesis. Herein, we developed the electrochemical etching process for the synthesis of Ti3C2 and Ti3CN MXenes by using aqueous tetrafluoroboric acid as the electrolyte, thus only involving a very low concentration of HF. The effect of electrical potential and temperature on the etching rate is studied and compared to chemical etching with HBF4. A mechanism based on the selective anodic dissolution of aluminium from the Ti3AlC2 and Ti3AlCN with the tetrafluoroborate ion is proposed. The MXene formation was confirmed by Raman spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction and electron microscopy. The MXene flakes from the electrochemical etching process have larger lateral dimensions compared to chemically etched MXene flakes as a result of the suppression of the HF decomposition and rapid etching rate. The electrodes of lithium-ion supercapacitors made from electrochemically etched Ti3C2 and Ti3CN exhibited cyclic performance and rate capabilities comparable to HF-etched MXenes.
Neuroendocrine tumor of thymus with ectopic production of adrenocorticotropic hormone in a 13-year-old child. Case report, 5-year follow-up
Authors: Slashchuk Konstantin Iu. , Reinberg Maria V. , Bazarova Ekaterina A. , Kareva Maria A. , Przhiyalkovskaya Elena G. , Degtiarev Mikhail V. , Pikin Oleg V.
Published: April 2024

Neuroendocrine tumors (NET) of the thymus are rare, usually aggressive, and prone to metastatic lesion. Ectopic adrenocorticotropic hormone (ACTH) secretion in thymic NET (TNEN) is associated with poor prognosis. Most of TNET express somatostatin receptors, it allows the use of somatostatin receptor scintigraphy (SRS) and SPECT/CT or PET/CT with 68Ga-labeled peptides for diagnosis and staging of the disease. Surgery (macroscopic-complete resection) is the mainstay treatment for TNET. Now, there are no unequivocal data in adjuvant therapy and its effectiveness. We present a case report of the pediatric patient with well differentiated atypical ACTH-producing thymic carcinoid. This localization was verified by whole body somatostatin receptor scintigraphy with 111In-DTPA-octreotide (Octreoscan). The patient proceeded with the surgical treatment followed by remission of hypercorticism without adjuvant chemotherapy. Tumor recurrence with redevelopment of ACTH-ectopic syndrome was detected after 67 months of observation.
Detection of mutations in the BRAF in patients with melanoma in routine clinical practice: Survey results
Authors: Orlova Kristina V. , Demidov Lev V.
Published: April 2024

Background. According to current clinical guidelines, patients with inoperable and/or metastatic melanoma (IMM) should undergo a molecular genetic study for the presence of mutations in the BRAF V600 gene in order to select drug therapy. Its accessibility and timing may vary in the regions of Russia.
Aim. To assess the possibility, accessibility, and timing of a molecular genetic study for melanoma in Russia.
Results. From November 15, 2023, to December 11, 2023, a survey was conducted, which included 32 respondents (oncologists and heads of depart- ments/laboratories) from various federal districts, where 1 to 1000 IMM patients are being diagnosed and treated annually. A mutation in the BRAF gene was detected in 79,1% of patients. The duration of the study was about 15 (3-35) days. The mutations were detected in a local institution in 60% of cases, within the Russian Society of Clinical Oncology diagnostic program in 21,1%, and in other programs in 18,9%.
Conclusion. The wide accessibility of the detection of BRAF gene mutations in the Russian Federation was reported due to the following factors: the introduction of molecular genetic diagnostics programs, in particular the Russian Society of Clinical Oncology program, as well as other programs sponsored by pharmaceutical companies and the possibility of testing under a compulsory health insurance policy. However, approximately 21% (20,9%) of patients with IMM do not test for mutations in the BRAF gene, even if they have their own laboratory in the institution. It is crucial to test all patients with melanoma from stage III onwards for BRAF mutations, especially when treatment is started with immunotherapy and there is enough time for the BRAF mutation result to be routinely obtained.
Irish enterprise digitalisation: A cross-country exploration
Authors: Hogan Karen , Kren Janez , O'Toole Conor
Published: April 2024

This research provides a cross-country perspective on the rate of digitalisation of Irish enterprises. We explore differences across countries, sectors and firm size categories by deploying data on both the usage of digitalisation technologies (stock of digital activities) as well as investment in new digital activities (flow). We draw on two main datasets: a) the Eurostat ICT usage in enterprises survey; and b) the European Investment Bank Investment Survey. We find that Ireland performs relatively well in terms of e-commerce and some more advanced technologies. However particular sectors and firm size groups (such as construction and smaller firms) display low levels of digitalisation. This supports the continued deployment of a sector-specific targeted policy approach that can cater for heterogeneous challenges faced by different firms. We find some evidence of correlations between enabling factors like employment skill levels and the cost of finance and the level of investment in digitalisation.
Authors: 刘 海龙
Published: April 2024

人际关系与媒介的话题,一直是国内传播学界不够关注的问题。最近看了2023年出的三本讨论人际关系的书《爱的终结:消极关系的社会学》《自我决定的孤独》《敏感与自我》,里面不约而同地提到社交媒介的影响。它们似乎与本期的关于老年研究和媒介化的话题,构成了一定的对话。
Photonic crystal fibre characterisation with the method of lines
Authors: Goncharenko Igor A. , Marciniak Marian
Published: April 2024

Photonic crystal fibres are longitudinally uniform fibres in which in lateral directions periodic refractive index changes occur. Two basically different light guiding mechanisms occur in crystal fibres: index guiding and bandgap guiding. In the paper different modelling methods have been evaluated when applied to photonic crystal fibres. In particular, the method of lines has been shown to be effective and reliable for both classes of photonic crystal fibres. High accuracy results for optical field distribution and dispersion characteristics in a photonic crystal fibre have been achieved with the method of lines.
Process and device requirements for mixed-signal integrated circuits in broadband networking
Authors: Iniewski Krzysztof , Syrzycki Marek , Voinigescu Sorin P.
Published: April 2024

The paper describes the present status of the broadband wireline infrastructure consisting of the backbone core, metro rings, access network, local and storage area networks. Examples of various mixed-signal integrated circuits are described. Based on these considerations required process and device performance is extrapolated.
Modeling SiGe-base HBT using APSYS 2000 - a 2D simulator
Authors: Adam Linkowski
Published: April 2024

The paper is devoted to optimization of SiGe-base HBT with respect to operation speed by means of numerical simulation. The influence of design parameters on fT is studied.
Recent developments in vertical MOSFETs and SiGe HBTs
Authors: Hall Stephen , Ashburn Peter , Buiu Octavian , Groot Kees de
Published: April 2024

There is a well recognised need to introduce new materials and device architectures to Si technology to achieve the objectives set by the international roadmap. This paper summarises our work in two areas: vertical MOSFETs, which can allow increased current drive per unit area of Si chip and SiGe HBT`s in silicon-on-insulator technology, which bring together and promise to extend the very high frequency performance of SiGe HBT`s with SOI-CMOS.
Influence of common path on availability of ring network
Authors: Rados Ivan
Published: April 2024

This paper analyses availability of the ring network which uses the path protection switching (sub-network connection protection - SNCP). Influence of the common path on the ring network availability is analyzed. Data regarding failures of optical fibre cables and equipment used for calculations have been obtained during years-long observation of SDH network in HT Mostar as well as from manufacturers.