bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of non-invasive Arterial Stiffness diagnostics in perioperative risk stratification for CABG
Authors: Malik Mohsyn , Nagpal A. Dave
Published: October 2021

Background: Arterial Stiffness (AS) is a novel marker shown to be an
independent predictor of coronary artery disease (CAD). However, AS has
been minimally studied for its predictive value in CAD outcomes
post-management. This review summarizes the current knowledge of AS and
its potential role as a risk stratifying marker in coronary bypass graft
(CABG) patients. Methods: A scoping review was performed to discover the
existing primary research on AS and its role as a predictive marker of
outcomes in CAD. MeSH terms were formulated for the database search. A
pre-set inclusion and exclusion criteria were created for appropriate
article retrieval. A qualitative analysis and syntheses of these
articles was conducted. Results: The search returned a total of 11
articles from 2005 to 2020 discussing the prognostic implications of AS
in CAD management. A majority of the articles found prognostic value of
AS in medically-managed and percutaneous-revascularized patients. Only 3
studies examined outcomes of CABG in-relation to pre-operative AS, which
were extremely limited in scope, though did show prognostic correlation
of post-op acute kidney injury. Conclusions: Despite the strong
relationship of AS and CAD, few studies have looked at its prognostic
value in patients undergoing surgical revascularization. Given the
expanding evidence for AS as a marker of CAD and the progression of
point-of-care technology to assess AS, this state-of-the-art measure
could be a valuable risk stratifying tool for surgeons considering CABG
for their patients, though further original research is needed.
Intrapulpal Concentration of Hydrogen Peroxide of Teeth Restored With Bulk Fill and Conventional Bioactive Composites
Authors: Silva DP , Resende BA , Kury M , André CB , Tabchoury CPM , Giannini M , Cavalli V
Published: October 2021

This study evaluated intrapulpal concentration and hydrogen peroxide (HP) penetration at the interface of teeth restored with bioactive composites, using conventional or bulk-fill composites. Cylindrical cavities were prepared on the buccal surface of bovine incisor crowns (n=20) and restored with: resin modified glass-ionomer (RMGI, Riva Light Cure, SDI), non-bioactive bulk-fill composite (FB, Filtek Bulk, 3M Oral Care), non-bioactive conventional composite (FZ, Filtek Z350, 3M Oral Care), bioactive bulk-fill composite (AC, Activa BioActive, Pulpedent), and bioactive conventional composite (BII, Beautifil II, Shofu). After 5,000 thermal cycles, restorations (n=10) were exposed to high (35% HP [4 applications of 8 min/session-4 sessions]) or low (9.5% HP [30 min/day-14 days]) concentration bleaching protocols. After the last bleaching application, the HP intrapulpal concentration was determined. Additional teeth were restored, pigmented with rhodamine B solution, and HP penetration around the interface was observed under laser scanning confocal fluorescence microscopy (LSCFM, n=3). The presence of gaps at the interface was observed on replicas of the cross-sectioned samples under scanning electron microscopy (SEM, n=5). Data were submitted to one-way (gap analysis) and twoway analysis of variance (ANOVA; HP intrapulpal concentration) and Tukey test (α=0.05). The LSCFM images were qualitatively analyzed. The restored teeth submitted to 35% HP presented higher HP intrapulpal concentration than teeth submitted to 9.5% HP (p<0.05). No differences in HP intrapulpal concentration was observed among groups (p>0.05) when exposed to 9.5% HP. Lower HP intrapulpal concentration was observed for teeth restored with RMGI exposed to HP 35%, when compared with teeth restored with nonbioactive conventional (FZ; p=0.004) and bulk-fill composites (FB; p=0.01). No gap formation was observed at the outer enamel adhesive interface for all restorative materials. LSCFM images showed that 35% HP promoted greater degradation of rhodamine B at the enamel, except for RMGI. In this context, RMGI promoted lower HP intrapulpal concentration than non-bioactive conventional and bulk-fill composites.
Déficit de investigación en instituciones de educación superior públicas
Authors: Sánchez Yoser G.
Published: October 2021

El SENA es un establecimiento público de orden nacional, el cual ofrece formación gratuita a los colombianos de manera presencial y virtual en sus diferentes sedes, distribuidas por todo el país. En una de sus sedes, ubicada en la ciudad de Medellín, Pedregal, se localiza el centro para el desarrollo del hábitat y la construcción, el cual cuenta con una infraestructura idónea y completa, equipada con laboratorios que permiten a todos los estudiantes que acuden allí, adquirir competencias para su desarrollo profesional, con personal profesional calificado, con experiencia en varios ámbitos educativos. Sin embargo, actualmente se observa en esta institu­ción que muchos de estos docentes carecen de espíritu investigativo.Por lo tanto, para este proyecto de investigación se busca analizar cuáles son los motivos por los que los docentes del Centro para el Desarrollo del Hábitat y la Construcción son apáticos con relación a los temas de investigación y solo se dedican a impartir formación de manera pre­sencial o virtual, además de identificar su repercusión en la institución. Por último, se propone realizar una estrategia de mejora, entendiendo que se cuenta con una infraestructura para ello, como son los laboratorios, talleres y equipos, entre otros, que permitirían la investigación y que pueden ayudar y aportar soluciones a muchas de las problemáticas que actualmente tiene el área de la construcción a nivel local, regional y nacional.
Diseño de prototipos y herramientas didácticas apoyadas en estrategias de investigación desde la formación profesional integral del SENA
Authors: Goyeneche López Freddy , Castro Ramírez Damián
Published: October 2021

La investigación centra su objetivo en diseñar prototipos y herramientas didácticas apoyadas en estrategias de investigación pedagógica para la formación profesional integral de los apren- dices del Sena Centro Nacional Colombo Alemán-CNCA Regional Atlántico. La metodología está enmarcada en la investigación científica-pedagógica, y se estrucuran tres acciones para el proceso de formación profesional integral, diseño de prototipos y herramientas didácticas para fortalecer procesos de enseñanza y aprendizaje en las diferentes áreas del conocimiento, estableciéndose una forma de trabajo independiente, cooperativo/colaborativo, virtual y presencial.

En los centros escolares donde son ofertados por el Sena, para los grados 10° y 11° de la doble titulación de bachilleres, los programas titulados como Análisis de Muestras Químicas, Meca- nizado y desarrollo de Software, entre otros, y ante el cumplimiento de los requisitos mínimos para ejercer la formación profesional integral en los respectivos ambientes educativos, se pre- sentan dificultades como la carencia y el averío de algunos materiales de diferente índole. Los resultados de la investigación muestran un trabajo responsable con la comunidad educativa y señalan la aceptación de los procesos de formación integral Sena para la vida y el trabajo.
Communicating vein between the right external and internal jugular veins: a case report
Authors: Patera Eleni , Alashkham Abduelmenem
Published: October 2021

The external jugular vein is a superficial vein that has a relatively diagonal to vertical course in the neck region and runs superficial to the sternocleidomastoid muscle. This vein is formed by the union of the posterior division of the retromandibular vein with the posterior auricular vein and it is responsible for draining most of the scalp and face as well. Sound knowledge of variations of the external jugular veins and the internal jugular veins, is important as these veins are used or targeted in specific medical procedures such as external jugular vein cannulation or radical neck dissection, respectively. During routine postgraduate dissection of the neck region in a 58-year-old female cadaver, the right external jugular vein was seen communicating with the right internal jugular vein via a communicating vein. The communicating vein was located approximately at the lower border of the thyroid cartilage and the upper border of the cricoid cartilage. A thorough understanding of anatomical variations is important in various medical disciplines and more specifically to anatomists, radiologists, and surgeons. This case report does not solely aim to increase awareness regarding variations of the jugular veins that can be possibly encountered during a neck endovascular procedure, but also contribute to the identification of the prevalence rate of this variation.
Protective role of sildenafil citrate in isoniazid-rifampicin induced histomorphological changes in liver of albino mice
Authors: Hameed Najma , Farooq Khalid
Published: October 2021

Objectives: The objective of the study was to reveal the reversal of histo-morphological changes in mice liver induced by combined isoniazid-rifampicin (INH-RIF) therapy with sildenafil treatment. Methods: Twenty-one mice weighing between 25–35 g were enrolled in the study. Randomisation was carried out by simple balloting method. The selected mice were sorted into three groups with 7 mice, each group. In group C (n=7) control group, mice were administered 0.4ml of saline per kg body weight daily intra peritoneally for 21 days. In group R (n=7) INH-RIF group, rifampicin (50 mg/kg) and isoniazid (50 mg/kg), dissolved in 4 ml/kg isotonic saline, were administered intra-peritoneally (ip) daily for 21 days. In group S (n=7) sildenafil administered group, 10 mg/kg sildenafil was given orally by gastric gavage on daily basis along with the intraperitoneal injection of INH-RIF (50 mg/kg each) daily for 21 days. Results: Histopathology revealed hepatotoxicity in group R (INH-RIF), while significant improvement was observed in group C (INH-RIF-sildenafil). Conclusion: Sildenafil citrate possesses hepatoprotective role against INH-RIF induced hepatotoxicity.
Lungs and hypoxia: a review of the literature
Authors: Sargon Mustafa F.
Published: October 2021

Acute, intermittent or chronic hypoxia have negative effects on lung maturation during the embryological period which has been shown by many experimental models designed on animal studies. The receptors responsible from the development of lungs in fetal period are affected from hypoxia. Hypoxia also affects the morphometry, anatomy and microscopy of lung tissue in the adults. In acute phase of hypoxia; lung parenchyma showed destructive oxidative changes. However, in later phases repair and proliferative processes were observed in the lung tissue. Damage to the lining layer of alveoli, accumulation of alveolar macrophages, oedematous changes in the lung parenchyma, mild oedema, inflammatory cell infiltration, increased number of type II pneumocytes and pulmonary fibrosis are the main findings in cases of hypoxia. Chronic hypoxia accentuates lung growth by increasing the lung parenchyma. Decrease of capillary volume and suppression of elastin repair in lung fibroblasts are other clinically important microscopic findings in hypoxia. Many molecular studies found in the literature revealed micro-RNAs to be involved in modulation of hypoxia-induced pulmonary hypertension. In animal models submitted to acute hypobaric hypoxia; the researchers detected an increase in eNOS mRNA which is responsible of the immediate response, producing nitric oxide that caused vasodilation and bronchodilation in lung tissue. In other molecular studies; suppression of many immune molecules, major changes at the levels of various enzymes and growth factors were detected in the researches. Additionally; hypoxia causes to an increase in the amount of lung cancer cells and therefore; induces the metastases of lung cancer cells to brain tissues.
Numerical variations and localization of foramen spinosum in 3D-CT images
Authors: Kastamoni Yadigar , Dursun Ahmet , Ayyıldız Veysel Atilla , Öztürk Kenan
Published: October 2021

Objectives: The structures passing through the foramen spinosum and its neurovascular relationships are of great importance for surgical approches directed to middle cranial fossa. The aim of the present study was to examine the number and location of the foramen spinosum (FS) in 3D-CT images. Methods: The study was retrospectively conducted on 3D-CT images of 177 adults. Firstly, the transverse section passing through the upper edge of the orbit, extending parallel to the Frankfurt plane was chosen. Then, the x and y-axes were determined on that transverse section. The coordinates, number, and location of the FS with respect to the foramen ovale (FO) were identified accordingly on x and y-axes. Results: While 1 FS was present in 90.96% of a total of 354 sides of 177 heads, there were 2 FS and 3 FS in 8.76% and 0.28% of the sides, respectively. The FS was located posterolaterally in 97.68%, posteriorly in 2.06%, and laterally in 0.26% with respect to the FO. In terms of FS coordinates, there was no statistically significant difference between gender and sides in the distance of the FS to the x-axis, but there was a statistically significant difference between gender and sides in the distance of the FS to the y-axis. Conclusion: Evaluation of the number of the FS and its location would help identifying and preserving neighbouring neurovascular structures during surgical interventions directed to the middle cranial fossa.
Circular economy and its disclosure in the basic concepts of improving production processes in construction
Authors: Kalmykova Maria Aleksandrovna , Kiseleva Elena Mikhailovna , Mironchuk Vadim Anatolevich , Sorgutov Ilya Valerievich , Barinov Sergey , Grigoriev Alexander Vladimirovich
Published: October 2021

The article discusses the features of the circular economy and its disclosure in the basic concepts of improving production processes in construction. The concept of a circular economy (CE) has recently become widespread as a perspective for solving global problems such as resource scarcity and waste management. The CE concept in the construction sector is rapidly gaining momentum and is used by many participants to coordinate their plans to build a more sustainable society. However, what exactly CE entails, remains unclear, and the actors involved in the transition to the CE set different priorities depending on their capabilities and goals. The transition to CE requires a more holistic approach and concerted efforts of all parties in the construction business.
Canción social latinoamericana: Una didáctica desde el audio texto para fomentar el pensamiento crítico en historia de América latina del siglo XX en los colegios Universidad Pontificia Bolivariana y María
Authors: Paniagua Giraldo Oswaldo , Hernández Henao Víctor Alfonso
Published: October 2021

El trabajo investigativo empleará la canción social latinoamericana para fomentar el pensamiento crítico mediante la didáctica del audio-texto basada en la selección de categorías temáticas de los movimientos musicales explorados y definidos desde los conceptos de emancipación, sociología de las ausencias y de las emergencias de Boaventura Sousa, que permitan a los estudiantes de sexto grado del Colegio Universidad Pontificia Bolivariana y del Colegio de María construir una perspectiva crítica de la historia social y política de América Latina durante el siglo XX. La metodología se centra en los análisis comparativos entre la sociología crítica y los temas de la canción social; y la técnica de composición crítico creativa con la que los estudiantes elaborarán textos, prosas, versos y canciones con nuevas categorías de ausencia y de emergencia
EL ESTADO DE BIENESTAR: UNA APROXIMACIÓN A LA INTERVENCIÓN ESTATAL
Authors: Arango Buelvas León Julio
Published: October 2021

El Estado de bienestar normalmente se relaciona con el componente social de las economía lo que implica tomar medidas ante la existencia de problemas que perturban el dinamismo de las economías, por lo que se requiere la actuación del Estado a través de instrumentos y de mecanismos jurídicos que a nivel institucional se dirigen a resolver dichos problemas, independientemente a que estos sean de tipo estructural o coyuntural.Cabe anotar que ante una presunta  inexistencia de problemas no se puede inferir la ausencia de los lineamientos estatales debido a que la presencia institucional pública es fundamental para el direccionamiento de las actividades que afecten los objetivos propuestos.En términos de aplicación de políticas es normal considerar que un gobierno puede actuar de varias formas, dentro de  las cuales puede ser  agente activo en la economía,  regulador o cumpliendo funciones  de supervisor. Lo anterior puede darse, sin alejarse del papel que le corresponde alrededor del bienestar social y orientando siempre sus acciones hacia la solución de los problemas o situaciones presentadas.Teniendo en cuenta este planteamiento, hay que tener claro que la política pública debe actuar en un escenario o campo de acción para su operacionalización y hacerla efectiva en función de los objetivos que se busca con su implementación. Es decir debe tener un direccionamiento en el campo económico, social, ambiental, internacional o de otra índole.
REVISIÓN AL EJERCICIO DEL PODER Y EL CAMBIO ORGANIZACIONAL EN LA E.F.
Authors: PERTUZ MARTINEZ AYLIN PATRICIA , SANTAMARIA ALVARO ENRIQUE , CADRAZCO PARRA WILSON GUZMAN
Published: October 2021

El estudio del poder tiene una historia reciente en la literatura organizacional. El poder se encuentra presente en la vida de las empresas, haciendo parte de la vida política de la misma. El cambio organizacional es uno de los procesos donde el poder se manifiesta. En las empresas familiares tiene dimensiones particulares en la sucesión y el relevo generacional. El objetivo de esta revisión es señalar las formas de intervención del poder en el cambio organizacional, en la vida de la empresa familiar y cómo actúa en los procesos de sucesión y cambio o relevo generacional. Se concluye que el ejercicio del poder toma fuerza en el cambio organizacional y muestra su complejidad en las empresas familiares; en éstas, los juegos de poder tienden a ser una traba en los procesos de sucesión y relevo generacional; el éxito o no de estos procesos podrá depender del modo en cómo se desarrolle el ejercicio del poder.
PLAN ESTRATÉGICO PARA EL ÁREA DE EXTENSIÓN Y PROYECCIÓN SOCIAL PROGRAMA DE ADMINISTRACIÓN DE EMPRESAS DE LA UNIVERSIDAD DE SUCRE CON BASE EN EL MODELO DE RESPONSABILIDAD SOCIAL UNIVERSITARIA
Authors: ROJAS MARTINEZ CLAUDIA PATRICIA , MARTINEZ JESUS SEBASTIAN , SALCEDO DIANA CAROLINA
Published: October 2021

El presente artículo muestra y analiza los resultados obtenidos de la investigación “Diseño de un plan estratégico para el área de extensión y proyección social del programa de Administración de Empresas de la Universidad de Sucre” tomando como referencia el Modelo para una reforma universitaria sobre la Responsabilidad Social Universitaria (RSU) de François Valleys y sus funciones sustantivas, gestión, docencia, investigación y extensión. En la investigación se empleóun modelo descriptivo, donde se trabajó con encuesta, focus group y entrevista que se aplicó a los diversos stakeholders (estudiantes, administrativos, egresados, personal docente y no docente) del programa de  Administración de Empresas de la Universidad de Sucre, además de una revisión documental. Los  resultados evidenciaron que los stakeholders poseen  desconocimiento sobre las variables y  los  ejes pragmáticos tales como, campus responsable, la formación ciudadana  y responsable, participación social y la gestión del conocimiento, por lo que se diseñó el plan estratégico  como producto  final de la investigación.
THE SOCIAL-PSYCHOLOGICAL AND PEDAGOGICAL ASPECTS OF ACMEOLOGY
Authors: Samvel Asatryan Miopap
Published: October 2021

Acmeology is an anthropological science, which studies person's spiritual, intellectual, physical, as well as individual, personal and professional development features, factors and patterns during his life maturity. The article describes the methodological bases of acmeology, its development stages, branches, scientific-practical problems related to the improvement of a person during his professional activity and the highest manifestation of his vital potential. Theoretical and practical issues of andragogy are interpreted based on the analysis of social survey data.
THE SKILL OF PARAPHRASING AS A COMMUNICATIVE AND COGNITIVE TOOL IN FOREIGN LANGUAGE ACQUISITION AT TERTIARY LEVEL
Authors: USTINOVA YELENA
Published: October 2021

The article highlights the use of paraphrasing as a universal skill, equally essential for effective speaking, writing, listening and reading. It discusses the role of paraphrasing in various communicative situations, specifying its significance in pre–service education of teachers and translators, and offers a list of strategies aimed at teaching the skill of paraphrasing.
Effect of Different Yarn Combinations on Auxetic Properties of Plied Yarns
Authors: Akgun Mine , Eren Recep , Suvari Fatih , Yurdakul Tugba
Published: October 2021

This study presents the effects of a novel plied yarn structure consisting of different yarn components and yarn twist levels on the Poisson's ratio and auxetic behavior of yarns. The plied yarn structures are formed with bulky and soft yarn components (helical plied yarn [HPY], braided yarn, and monofilament latex yarn) and stiff yarn components (such as high tenacity [HT] and polyvinyl chloride [PVC]-coated polyester yarns) to achieve auxetic behavior. Experimental results showed that as the level of yarn twist increased, the Poisson's ratios and the tensile modulus values of the plied yarns decreased, but the elongation values increased. A negative Poisson's ratio (NPR) was obtained in HT–latex and PVC–latex plied yarns with a low twist level. The plied yarns formed with braid–HPY and braid–braid components gave partial NPR under tension. A similar result was achieved for yarns with HT–latex and PVC–latex components. Since partial NPR was seen in novel plied yarns with braided and HPY components, it is concluded that yarns formed with bulky–bulky yarn components could give an auxetic performance under tension.
Audio Database for TIAGo Service Robot
Authors: Grama Lacrimioara , Muscar Lorena , Rusu Corneliu , Telembici Toma
Published: October 2021

In this paper we present an updated version of the audio database acquired by the TIAGo service robot and by the simulated TIAGo service robot. To the initial database which consists in 1380 audio signals we have added 1920 more acoustic signals. The audio database consists now in 3300 isolated audio events corresponding to 110 classes. All the recorded sound events correspond to the indoor environment, and they are spread into five different scenarios: kitchen, room, appliances, voice and non-verbal. The audio database is intended to be used in order to identify indoor events based on audio signature, especially when elderly or chronically ill people live alone.
Increasing Energy Efficiency Using Photovoltaic Panels
Authors: Pop Horațiu , Grama Alin
Published: October 2021

The paper analyses the way of design of photovoltaic systems. The objective of this paper is to study the production capacity of electrical energy and the way it is influenced by real time conditions. In order to realize some energetic models that could be implemented on a large scale and used as a model of good practice we used photovoltaic systems of 3 dimensions: 60 PV panels, 100 PV panels and 160 PV panels respectively. The present study considered the climate conditions of the city of Cluj-Napoca for 12 months. It considered the consumption profile (hourly consumption) and the period of the year (summer, winter, etc.) for 3 typical buildings. We used Matlab/Simulink software for simulations. The result is an estimation of the production of electrical energy for renewable sources and the reduction of GreenHouse Gases (GHG). The aim is to reduce both GHG and the energy consumption from conventional sources.
Designing a Low-Code CRUD framework
Authors: Văduva Bogdan , Vălean Honoriu
Published: October 2021

Nowadays programmers write source code for inserting, editing and deleting records of a relational table. The majority of commercial relational databases include a specific management tool that offers such possibilities and most database programmers take this ability as granted. When it comes to real life applications, programmers use Object Oriented (OO) paradigm to build user friendly windows/screens/forms for database operations. The current work shows a different approach using a Low-code CRUD (Create, Read, Update, Delete) framework. Views and guidelines of how to design a Low-code CRUD framework will be detailed. “Low-code” motivation is due to the fact that the new framework will provide the ability to use less code in order to build fast and efficient complex applications. It will be up to the reader to envision a specific framework.
Hardware accelerated image processing on FPGA based PYNQ-Z2 board
Authors: Mándi Ákos , Máté Jeney , Rózsa Dominik , Oniga Stefan
Published: October 2021

In this paper we present the partial results of a research in progress made in order to develop a prototype of a self-driving car’s controller and processing unit. The framework that we used consisted of a camera for input of visual imagery information (Logitech 720p), a laser range finder for depth and object sensing (Parallax; PulsedLight LIDAR-Lite v2), and the main processing board, an FPGA based accelerator board PYNQ Z2.
Towards a New Global Development Paradigm and Restructuring the Economy Into a Sustainable
Authors: Svitačová Eva Pechočiaková , Moravčíková Danka
Published: October 2021

The current economy transcends the boundaries of sustainability, threatens the quality of life on Earth and, ultimately, of the man himself, which requires its restructuring to a sustainable one. The unsustainability of the development of society, which causes the development of the economy in a global environment, is revealed by theoretical research based on qualitative analysis of texts and documents. Subsequently, the need to change the paradigmatic basis of economic theory is explained and a new model of economy – sustainable economy – is outlined. Using logical methods and comparison of basic axioms, postulates and based on the prediction of further development, the study emphasizes that moving towards a more sustainable future presupposes the replacement of neoclassical paradigm by a new paradigm – the paradigm of sustainable development. Restructuring the economy into a sustainable one will be based on this paradigm, as confirmed by some of the outlined new economic theories and initiatives.
Biomarkers of Systemic Versus Local Inflammation During the Acute Phase of Myocardial Infarction, as Predictors of Post-infarction Heart Failure
Authors: Matyas Botond , Polexa Stefania , Benedek Imre , Buicu Andreea , Benedek Theodora
Published: October 2021

Background: The aim of this study was to investigate the correlation between serum biomarkers of left ventricular dysfunction and systemic inflammation in the first days after the acute episode, and to investigate their role for early identification of patients at high risk for post-infarction heart failure.

Materials and methods: In total, 123 subjects admitted to the Intensive Cardiovascular Care Unit of the Cardiology Clinic of the Târgu Mureș County Clinical Emergency Hospital, Romania, with acute myocardial infarction were retrospectively analyzed in this study. Based on the level of NT-proBNP, the study population was divided into 2 groups: Group 1 (n = 92), with NT-proBNP <3,000 pg/mL, and Group 2 (n = 31), with NT-proBNP >3,000 pg/mL.

Results: Biomarkers reflecting systemic inflammation presented significantly higher values in patients with elevated NT-proBNP (hs-CRP – 12.3 ± 8.9 mg/L vs. 3.6 ± 6.7 mg/L, p <0.0001, and interleukin 6 – 27.6 ± 30.7 pg/mL vs. 8.6 ± 6.2 pg/mL, p <0.0001). However, cell adhesion molecules VCAM and ICAM were not significantly different between the groups. Patients in Group 2 presented significantly higher rates of major cardiovascular events and rehospitalizations in the first year after the acute coronary event, with 13.33% event rate for patients in Group 2 compared to 8.7% in Group 1 (p <0.05).

Conclusions: Serum biomarkers of ventricular dysfunction are strongly associated with systemic inflammation and ventricular impairment in the immediate phase after an acute myocardial infarction. Systemic inflammation has a higher impact on the clinical outcomes and progression to heart failure than the local coronary inflammation expressed by cell adhesion molecules.
Telemedicine in haemophilia during COVID-19 and beyond: a comprehensive review
Authors: Li Casey L , Chan Anthony KC , Matino Davide , Bhatt Mihir D , Decker Kay , Strike Karen
Published: October 2021

Introduction

Patients with haemophilia require regular assessments and physical examinations. The COVID-19 pandemic has resulted in the rapid adoption of telemedicine to enable virtual consultations and reduce hospital visits. However, the process of virtual consultations is new to many haemophilia clinics. A better understanding of best practices in telemedicine is important to ensure optimal quality of care for patients with haemophilia.

Objectives

To summarise the current literature on the use of direct-to-consumer telemedicine for patients with haemophilia and to describe the effectiveness and potential limitations of the technology and methods used.

Methods

A comprehensive search was conducted in MEDLINE and EMBASE databases using terms referring to the concepts “haemophilia” AND “telemedicine” and their synonyms. There were no time or language restrictions. Title, abstracts, and full texts were screened. Included articles involved telemedicine interventions to facilitate clinical services directly between patients and providers without the use of third-party personnel. The primary outcome was the satisfaction of providers and patients. Secondary outcomes included economic considerations and clinical outcomes. Information was extracted based on study-specific, patient-specific, intervention-specific, and outcome-specific data.

Results

Of the 925 articles screened, six were identified and summarised. Three described telemedicine within the context of COVID-19. Technologies used included telephone calls, videoconferencing, text messaging, and email. All studies involved a multidisciplinary team. Telemedicine in haemophilia care was found to positively impact the patient experience. Providers were satisfied with telemedicine. It was also suggested to be economically beneficial and positively impacted patient outcomes. However, none of the articles reported on how telemedicine was specifically used to perform assessments during the virtual consultation process.

Conclusions

There is preliminary evidence that telemedicine may be beneficial in haemophilia care. Overall, patients and providers reported high satisfaction with the usage of direct-to-consumer telemedicine. This positive reception warrants improvements in standardisation of reporting and quality of study design to better assess its clinical and economic impact. Developing a standard guideline for virtual consultations would support healthcare practitioners in how to best incorporate telemedicine to improve quality of care.
Bone mineral density in Canadian children with severe haemophilia A or B: a cross-sectional study
Authors: Bos Cecily , Tieu Paul , Wu John K , Strike Karen , Chan Anthony KC
Published: October 2021

Background

Previous research has shown that bone mineral density (BMD), a measure of bone strength, may be lower among people with haemophilia. However, the majority of this research has been done in adults and in countries where the treatment for haemophilia differs from the standard of care in Canada, and there is a lack of paediatric data.

Aims

The primary objective of this study was to determine whether Canadian children and youth with severe haemophilia A and B have BMD similar to healthy controls matched for height, age and weight (HAW-score). Secondary objectives included the exploration of any association between BMD and the following variables: factor replacement regimen, Hemophilia Joint Health Score (HJHS), bleeding history, physical activity level, and dietary intake of calcium, vitamin D, vitamin K and protein.

Methods

A cross-sectional observational study was designed to determine the BMD of children with severe haemophilia A and B in Canada. Ethical approvals were obtained from participating institutions. Thirty-eight participants aged 3–18 with severe haemophilia A and B were recruited from two treatment centres in Canada. Subjects underwent dual-energy X-ray absorptiometry (DXA) scan, and data was collected from regular clinic visit to identify factor replacement regimen, HJHS, and number of joint bleeds over the lifespan. Physical activity level and dietary intake of calcium, vitamin D, vitamin K and protein were identified using self-report questionnaires.

Results

Participants showed a mean spine BMD Z-score and HAW-score higher than controls, with no participants showing a spine Z-score or HAW-score of <0. Hip BMD score was within normal range, and 2 participants had a Z-score and HAW-score of <−2. Total body BMD score was lower than controls, with 6 participants having a Z-score of <−2.0, and 3 participants having a HAW-score of <−2.0. Factor replacement regimen, HJHS, calcium intake, and physical activity level had no relationship to BMD Z-score or HAW-score. Low intake of vitamin D was associated with a low hip and spine BMD Z-score and HAW-score. Participants with a HJHS joint score greater than 0 had a higher total body HAW-score than those who had a joint score of 0.

Conclusion

Canadian children with severe haemophilia A and B demonstrate differences in spine and total body BMD from height-, age-, and weight-matched controls, where spine BMD is higher than controls and total body BMD is lower than controls. Studies with a larger sample size are needed to clarify the status of BMD in children with haemophilia treated with primary prophylaxis.
Haemophilia specialist nurses’ perceptions of haemophilia B
Authors: Chaplin Steve , Birkedal Maj Friberg , Crilly Erica , Fletcher Simon , Garcia Sara , Mulders Greta , Myrin-Westesson Linda , Pollard Debra , Sanigorska Anna , Uitslager Nanda
Published: October 2021

Introduction

Some clinicians believe that haemophilia B is associated with less bleeding than haemophilia A, yet there appears to be little difference in health-related outcomes. Current clinical practice reduces the risk of bleeds, making differences difficult to measure. We surveyed specialist haemophilia nurses to discern their opinions about the impact of haemophilia B compared to haemophilia A.

Methods

Between July and September 2020, European and Canadian nurses were invited to complete an online survey (25 questions) about perceptions of management and treatment of haemophilia B.

Results

Fifty-nine nurses (46 European, 13 Canadian) completed the survey. Bleeding was reported as different in haemophilia B by 37% of respondents, and treatment as different by over half. Opinions and experience around using extended half-life (EHL) products varied. Self-reported confidence in using EHL products was rated at a mean of 7.1 (range 3–10) with 47% believing these would remain the optimal treatment in 2025.

Conclusion

Some nurses believe haemophilia A and B are managed differently. Variations in experience and levels of confidence in the use of EHL products, combined with a belief that these products will remain an optimal treatment for haemophilia B for the next five years, indicates a need for education to promote confidence and competence.
Correlation between Magnetic Resonance Imaging and Arthroscopic Findings in Knee Lesions
Authors: Russu Octav , Feier Andrei , Ciorcila Emilian , Miler Georgiana , Trambitas Cristian , Borodi Paul-Gabriel
Published: October 2021

Background: Magnetic resonance imaging (MRI) is a noninvasive diagnostic method with no known side effects and a high sensitivity for detecting meniscal lesions as well as lesions of the anterior and posterior cruciate ligaments. For a correct and complete diagnosis, MRI results must be interpreted in the context of clinical examination and anamnesis. MRI results can support the surgical indication for arthroscopy, which is a minimally invasive intervention that facilitates the visualization, investigation, diagnosis, and treatment of intra-articular lesions of the knee. The purpose of this study was to assess the correlation between MRI results and the intra-articular lesions detected arthroscopically.

Material and methods: This retrospective study evaluated a total of 60 patients admitted and treated between January 1, 2013 and January 1, 2014 in the Clinic of Orthopedics and Traumatology of Mureș County Hospital, Târgu Mureș, Romania.

Results: In the 43 patients with lesion of the anterior cruciate ligament, the lesions were seen on MRI in 40 patients (93%) and confirmed arthroscopically in 37 patients (86%). In 34 cases (79.1% of the total of 43), the MRI and arthroscopic results were similar, the Kappa coefficient showing a high degree of correlation (0.90).

Conclusion: By assessing the Kappa coefficient to highlight the correlation between MRI results and arthroscopic diagnosis for knee injuries, a statistically relevant correlation between the two methods was found. This suggests that a correct diagnosis can be achieved by both methods.
Etiopathogenic and Clinical Aspects in Inflammatory Bowel Disease – Literature Review
Authors: Isac Petronela Nicoleta Seritean , Popescu Diana , Genes Tudor Marcel , Badescu Minerva Codruta , Rezus Ioana Irina , Dima Nicoleta , Ganceanu Ana Roxana Rusu , Rezus Elena , Rezus Ciprian
Published: October 2021

Inflammatory bowel disease (IBD) is a chronic inflammatory condition which encompasses Crohn’s disease and ulcerative colitis. IBD does not only affect the gastrointestinal system, but also associates many extraintestinal complications that can affect almost any organ. A large number of patients may have these complications before or after the diagnosis of IBD. Early diagnosis and management of these complications involves a multidisciplinary team and contributes to decrease patient morbidity and mortality, but also to increase the quality of life. The purpose of this extensive literature review is to present systematically and comprehensively the latest data on the extraintestinal manifestations of IBD, and to draw clinicians’ attention to the fact that this condition can have extradigestive manifestations that can be misleading and delay the diagnosis.
Explain the law: When the evidence is not enough
Authors: Benešová Martina , Faltýnek Dan , Zámečník Lukáš Hadwiger
Published: October 2021

The article responds to the current variability of research into linguistic laws and the explanation of these laws. We show basic features to approach linguistic laws in the field of quantitative linguistics and research on linguistic laws outside the field of language and text. Language laws are usually explained in terms of the language system—especially as economizing—or of the information structure of the text (Piantadosi 2014). One of the hallmarks of the transmission of linguistic laws outside the realm of language and text is that they provide other kinds of explanations (Torre et al. 2019). We want to show that the problem of linguistics in the explanation of linguistic laws lies primarily in its inability to clarify the internal structure of language material, and the influence of the theory or method used for sample processing on the result of law analysis—which was formulated by Peter Grzybek (2006). We would like to show that this is the reason why linguistics avoids explanations of linguistic laws.
Da possibilidade de Uma Fenomenologia implícita em Kant e Descartes Uma breve perspectiva
Authors: Sidoncha Urbano Mestre
Published: October 2021

In this paper, we will consider the following issue: the innovative dimension of E. Husserl’s phenomenology repeatedly finds in the philosophies of Descartes and Kant a clear obstacle for its full comprehension. After all, is it not the case that the former discipline is just an extension of the perspectives stated by those earlier philosophers? But, to state the idea of a hidden phenomenology in the philosophies of Descartes and Kant has not, as its unavoidable counterpart, the dependence and the full commitment of Husserl ‘s phenomenology with positive doctrines as the one sponsored by Descartes and Kant? And, if so, how can we rescue the idea of phenomenology as prima philosophia?
Possibilidades de sentido Jan Patočka e o cuidado da alma
Authors: Rodrigues Inês Pereira
Published: October 2021

This paper tries to explore the phenomenon of meaning through an investigation of Jan Patočka’s asubjective phenomenology. Meaning, according to this author, is problematic: it lies neither at rest in the things themselves, nor is it merely subjective – a more or less arbitrary human imposition. Instead, meaning, like all phenomena, belongs to the “phenomenological field”, also encompassing those experiences typically called “subjective”. In this sense, meaning is relational, that is, it lies in the relation of “ having meaning for a subject”. Accordingly, it is dependent on a kind “openness” to meaning. “Care of the soul”, a term patočka takes over from the Ancient Greeks, is precisely a reflexive exercise upon this openness, this attunement to, ultimately, the very problematicity of meaning. This dynamic also seems to imply that meaning could be open to, not only unveiling, but to its (co-)creation.
A Experiência do Tempo nos Zollikoner Seminare de Heidegger
Authors: Borges-Duarte Irene
Published: October 2021

This paper seeks to understand Heidegger’s phenomenological analysis of the time experience in Sein und Zeit, from the formal point of view of the Care-structure, and in the Seminars of Zollikon, where time is described as world-time in its fullness. Aimed is to show that the early anthropological reception of his major work of 1927 by some of his pupils, like Löwith, who detected similarities with Psychoanalysis, is somehow strengthed by Heidegger himself later on, as he comes with Medard Boss to develop Daseynsanalysis as a metaonlogical understanding of humans life in health and pathology. Illness as privation of health will be seen as the failure of inauthentic existence. And the full, ecstatical experience of time will be shown as the proper or authentic one, being-in-the-world as well as within the psychoanalytical session and interpretation.
Les Parallèles Convergentes Objets et valeurs dans l’éthique phénoménologique d’Edmund Husserl
Authors: Mariani Emanuele
Published: October 2021

In the most recent debate of phenomenological as well as analytical provenance, Husserl’s reflection, although pioneer regarding ethics, seems to suffer of a general depreciation enrooted in his supposed excess rationalism.

The husserlian ethics would remain subjected to the dominance of a logico-objectifying reason, which appears to be the fundamental dimension of intentionality. The wide range of life-experiences would then be crushed by the hegemony of objectifying acts. Are we really sure? Our contribution will rather consist in raising the originality of Husserl’s method which lastly to reconcile two seemingly contradictory requirements: the autonomy of ethical and its dependence towards logical reason. We shall notice thus a progressive dissociatoon from Brentano’s teaching leading to an overall revision of intentionality. If anything such as rationalism exists in Husserl’s thinking, it can only be asserted on the condition of a radical criticism of the concept of “representation” – from where, as we shall see, emerges a newly articulated relationship between “object” and “value”.
Mundo da vida e Direito Natural. Uma Fundamentação Fenomenológica dos Direitos Humanos?
Authors: de Sousa Ana Paula Loureiro
Published: October 2021

The justification of Natural Law is a very controversial issue, not only after the Positivist’s rebuttals, but since its very anthropological foundations in the early modern age. In this paper, I try do give an account of Natural Law and natural rights in terms of a phenomenological description of the background of normative intentionality. Taking a genetic stance, I go from the positive norm and the intentionality that constitutes it to the underling pregiveness that supplies the condition of its possibility. I exhibit it as the experience of the live-world, and I analyze it as an intersubjective world, where persons are given as equals and worth-counting. This is the very root of the concept of human dignity. Starting from it, I develop an account of the sense and content of the concept of Human Rights as a set of eidetic laws creating the framework for authentic human relationships.
Reinvestigations of the Li2O–Al2O3 system. Part I: LiAlO2 and Li3AlO3
Authors: Tabero Piotr , Frąckowiak Artur , Dąbrowska Grażyna
Published: October 2021

Reinvestigations of the Li2O–Al2O3 system focused on the synthesis and properties of LiAlO2 and Li3AlO3 phases have been performed with the help of XRD and IR measuring techniques and Li2CO3, LiOH·H2O, Al2O3-sl., α-Al2O3, Al(NO3)3·9H2O and boehmite as reactants. Results of investigations have shown the formation of α-, β-, and γ- polymorphs of LiAlO2. It was found that only the use of LiOH·H2O as a reactant yields to β-LiAlO2 as a reaction product. On the other hand, it was proved that Li3AlO3 does not form in the Li2O–Al2O3 system. A new method for the synthesis of α-LiAlO2 was developed, consisting in grinding the mixture of Li2CO3 and Al(NO3)3·9H2O and heating the obtained paste at the temperature range of 400–600 °C. The IR spectroscopy was used to characterize obtained phases.
Learning Model And Logical Thinking Ability in Redox Reaction Learning
Authors: Sugiharti* Gulmah , Azura Wan
Published: October 2021

The implementation of the 2013 curriculum has not been fully implemented in Private High School Angkasa Medan , because teachers do not fully understand the learning model that must be used. This has an impact on the results of student chemistry learning that not all students are able to achieve the set minimum completeness score target of 75. This study is about the application of learning models and the ability to think logically in redox learning in class X Private High School Angkasa Medan. The population consisted of 6 class X students and the sample was taken purposively by setting 2 classes for the research sample. Both classes are taught with two models, with a combination of factorial 2 X 2. There are two factors tested, namely factor A in the form of a learning model consisting of Problem Based Learning (PBL) and Direct Instruction (DI) models, factor B: logical thinking ability high and low logical thinking ability. Data analysis techniques using 2-way ANOVA. Based on the hypothesis test at a significant level of α = 0.05, it shows that there is an influence of the learning model and students' logical thinking ability on the learning outcomes of topic redox chemistry, and there is an interaction between the learning model and the ability to think logically towards the redox learning outcomes. The results of the BNT advanced test indicate that the Problem Based Learning Model is better than the Direct Instruction model on topic redox chemistry learning.