bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors influencing the discontinuation of biologic therapies in patients with ulcerative colitis
Authors: Fukuyama Arisa , Nakashima Akio , Miyazaki Motoyasu , Fujiki Masakatsu , Kakimoto Hideki , Hisabe Takashi , Imakyure Osamu
Published: October 2024

Background

The therapeutic landscape for ulcerative colitis (UC) has recently broadened to include anti-TNFα, anti-integrin, and anti-IL-12/23p40 antibody agents. These biological agents are tailored to individual patient profiles. However, some patients cease biological treatment. This study investigates factors influencing the discontinuation of biological treatment in UC patients.

Methods

This retrospective single-cohort study encompasses UC patients who commenced treatment with biological agents like infliximab, adalimumab, golimumab, vedolizumab, and ustekinumab from April 2019 to March 2022. Patients were categorized into continuation and discontinuation groups based on their one-year treatment status. Baseline characteristics were compared between the groups.

Results

Of the 116 UC patients, 102 were included in the study. Among these, 74 (72.5%) continued and 28 (27.5%) discontinued biological therapy. Discontinuation rates for infliximab, adalimumab, golimumab, vedolizumab, and ustekinumab were 33.3%, 25.0%, 50.0%, 30.2%, and 15.6%, respectively. The primary discontinuation reason was lack of efficacy (85.7%), followed by adverse events (7.1%), pregnancy (3.6%), and death (3.6%). The discontinuation group had a significantly lower rate of concomitant thiopurine compared to the continuation group (28.6% vs. 56.8%, p = 0.0132). Multivariable analysis revealed that concomitant thiopurine was independently associated with therapy continuation (p = 0.0075).

Conclusion

The study indicates that concomitant thiopurine significantly correlates with the continuation of biological therapies in UC patients, underscoring the importance of concomitant thiopurine in sustaining biological therapy. Further studies are warranted to assess the efficacy of combination therapy.
Validation of 11 added items of the outpatient version of the Utrecht Symptom Diary in patients receiving chemotherapy or targeted therapy
Authors: Koldenhof Josephine J. , Akpobome Bernice O. , Zweers Danielle , Klaasse Stance , Teunissen Saskia C. C. M. , Witteveen Petronella O. , Suijkerbuijk Karijn P. M. , de Graeff Alexander , van der Baan Frederieke H.
Published: October 2024

Introduction

The Utrecht Symptom Diary (USD) is a validated Dutch patient-reported outcome measurement (PROM) tool - based on the Edmonton Symptom Assessment System - to assess and monitor symptoms in cancer patients. The USD contains 11 items concerning frequently occurring symptoms in cancer patients (pain, sleeping problems, dry mouth, dysphagia, lack of appetite, abnormal stool, nausea, shortness of breath, fatigue, anxiety and depressed mood) and an item on overall well-being. For the outpatient USD 11 items concerning frequently occurring signs and symptoms in patients receiving chemotherapy and/or targeted therapy were added to the USD: taste alteration, oral pain, weight loss, diarrhoea, hair changes, skin problems, nail problems, eye problems, tingling, concentration problems and problems with sexuality. This current study aimed to evaluate the 11 added items on this treatment specific outpatient USD in cancer patients receiving intravenous chemotherapy and/or targeted therapy.

Methods

Observational longitudinal retrospective cohort study including all adult outpatients with cancer receiving intravenous chemotherapy and/or targeted therapy in an academic hospital in the Netherlands who completed at least one outpatient USD as part of routine care (2012–2021). Relevance, comprehensiveness as well as criterion and construct validity were assessed.

Results

1733 patients who completed ≥ 1 outpatient USD during intravenous chemotherapy and/or targeted therapy were included for analysis. Relevance as well as comprehensiveness of the items on the outpatient USD in this patient population was shown. Criterion validation was demonstrated for all added items of the outpatient USD – except for the item on oral pain. An additional analysis showed that mouth problems were detected with both outpatient USD items oral pain and dry mouth. Construct validity was demonstrated for the items hair changes and skin and nail problems. Construct validity on eye problems was not tested due to the low number of paired outpatient USDs.

Conclusions

The treatment specific outpatient USD is a validated PROM in outpatients with cancer receiving intravenous chemotherapy and/or targeted therapy. Considering its validity in this broad group of patients, we think the treatment-specific outpatient USD is widely applicable. In addition to providing tailored supportive symptom care, the USD-data can be used to increase knowledge about symptom burden in daily practice in this population.
Gadolinium-based coronary CT angiography on a clinical photon-counting-detector system: a dynamic circulating phantom study
Authors: Kravchenko Dmitrij , Gnasso Chiara , Schoepf U. Joseph , Vecsey-Nagy Milan , Tremamunno Giuseppe , O’Doherty Jim , Zhang Andrew , Luetkens Julian A. , Kuetting Daniel , Attenberger Ulrike , Schmidt Bernhard , Varga-Szemes Akos , Emrich Tilman
Published: October 2024

Background

Coronary computed tomography angiography (CCTA) offers non-invasive diagnostics of the coronary arteries. Vessel evaluation requires the administration of intravenous contrast. The purpose of this study was to evaluate the utility of gadolinium-based contrast agent (GBCA) as an alternative to iodinated contrast for CCTA on a first-generation clinical dual-source photon-counting-detector (PCD)-CT system.

Methods

A dynamic circulating phantom containing a three-dimensional-printed model of the thoracic aorta and the coronary arteries were used to evaluate injection protocols using gadopentetate dimeglumine at 50%, 100%, 150%, and 200% of the maximum approved clinical dose (0.3 mmol/kg). Virtual monoenergetic image (VMI) reconstructions ranging from 40 keV to 100 keV with 5 keV increments were generated on a PCD-CT. Contrast-to-noise ratio (CNR) was calculated from attenuations measured in the aorta and coronary arteries and noise measured in the background tissue. Attenuation of at least 350 HU was deemed as diagnostic.

Results

The highest coronary attenuation (441 ± 23 HU, mean ± standard deviation) and CNR (29.5 ± 1.5) was achieved at 40 keV and at the highest GBCA dose (200%). There was a systematic decline of attenuation and CNR with higher keV reconstructions and lower GBCA doses. Only reconstructions at 40 and 45 keV at 200% and 40 keV at 150% GBCA dose demonstrated sufficient attenuation above 350 HU.

Conclusion

Current PCD-CT protocols and settings are unsuitable for the use of GBCA for CCTA at clinically approved doses. Future advances to the PCD-CT system including a 4-threshold mode, as well as multi-material decomposition may add new opportunities for k-edge imaging of GBCA.

Relevance statement

Patients allergic to iodine-based contrast media and the future of multicontrast CT examinations would benefit greatly from alternative contrast media, but the utility of GBCA for coronary photon-counting-dector-CT angiography remains limited without further optimization of protocols and scanner settings.

Key Points

GBCA-enhanced coronary PCD-CT angiography is not feasible at clinically approved doses.

GBCAs have potential applications for the visualization of larger vessels, such as the aorta, on PCD-CT angiography.

Higher GBCA doses and lower keV reconstructions achieved higher attenuation values and CNR.

Graphical Abstract
Effect of individual quick freezing treatment and cold storage on the host egg (Lepidoptera: Saturniidae) quality for the production of the parasitoid Anastatus japonicus Ashmead (Hymenoptera: Eupelmidae)
Authors: Wu Yi-Hui , Lee Shih-Yang , Chuang Yi-Yuan , Tzeng Hsy-Yu , Lai Jui-Sheng , Chou Ming-Yi
Published: October 2024

Background

The augmentative release of the parasitoid species Anastatus japonicus Ashmead (Hymenoptera: Eupelmidae) is essential for managing the recent invasion of litchi stink bugs (Tessaratoma papillosa (Drury)) (Hemiptera: Tessaratomidae) in Taiwan. The mass release program in the spring targets this univoltine pest’s reproduction cycle. Low-temperature storage for the host eggs and parasitoids is required to maximize the production for the annual release program. This study aimed to enhance the shelf life of Samia cynthia (Lepidoptera: Saturniidae) eggs using the combination of refrigeration and individual quick freezing (IQF) as a storage treatment. Storage of A. japonicus in the IQF-treated S. cynthia eggs was evaluated to determine the optimal production process during the short preparation window before the release.

Results

The influences of cold storage and IQF treatment on the host eggs were evaluated for different storage durations. The host quality was determined according to the emergence rate and female ratio of A. japonicus. The study’s results demonstrated that the host quality of S. cynthia eggs did not change significantly compared to the control group after 28 d of refrigeration at 7 °C. IQF treatment extended S. cyathia’s shelf life to 5 months without significantly affecting the host quality. Applying IQF at different developmental stages of the host eggs affected the parasitism rates of A. japonicus. Significantly higher emergence rates of A. japonicus were recorded in the eggs treated during the initial development (D0 to D2). However, storing parasitoids in the IQF-treated eggs under the current storage condition for one month at 12 °C significantly impacted the parasitoid’s emergence rate.

Conclusions

The results of this study highlight the potential benefits of the individual quick freezing technique. This technique didn’t alter the egg quality of S. cynthia, a crucial factor for the mass production of A. japonicus. The IQF treatment extends the shelf life of the host eggs to 5 months when stored at − 20 °C, a significant improvement compared to the 4-week shelf life without IQF treatment. This technology offers a promising and efficient approach for the mass production of A. japonicus and supports field releases. The treatment allowed for the stockpiling of host eggs during the off-season, which can help expedite the mass production of A. japonicus to fit an eight-week production window.
Recovery and purification of kish graphite from steelmaking dust by using acid leaching with physical auxiliary methods
Authors: Chen Ying-Liang , Chiang Wei-Ping , Lin Ching-Huai , Wu I-Min , Chang Juu-En
Published: October 2024

Graphite has been a critical raw material in recent years due to its high economic importance and high risk of supply disruptions. The traditional source of graphite is natural graphite ores; however, the production of natural graphite ores is controlled by few countries. It is thus important to find an alternative source of graphite, and steelmaking byproducts, such as dust and slag, can be considered because of their high potential for the recovery of kish graphite. The original kish graphite normally has a low carbon content and large amounts of impurities, and purification is necessary before using kish graphite in industry. The purpose of this study was to recover kish graphite from steelmaking dust by combining multi-stage froth flotation and acid leaching processes. The conditions of acid leaching were examined, and physical auxiliary methods (heating, microwave irradiation, and ultrasonication) were studied. After the multi-stage froth flotation process, the carbon content of the kish graphite was approximately 84 wt%, and Fe, Ca, Al, Na, K, Si, and Mg were the major elements of impurities. The acid leaching process was useful for enhancing the carbon content of the kish graphite and removing the impurities, particularly when using HCl and HBF4. However, HCl should be a more appropriate selection for acid leaching when considering the price of acids. The carbon content of the kish graphite reached ~ 95 wt% when using 1.0 N HCl with ≥ 30 min of reaction time and a ≥ 5 L kg−1 liquid-to-solid ratio. The physical auxiliary methods can further increase the carbon content of the kish graphite. The kish graphite purified by heating 1.0 N HCl at 80 °C for 5 min had the highest carbon content of approximately 97 wt%. The purified kish graphite and the natural graphite had similar crystallinity and lamellar structures, but the purified kish graphite had more structural defects. The recovery of kish graphite from steelmaking dust can obtain valuable materials and should have benefits for the environment.
Validation of abdominal ultrasound examination for assessment of abdominal wall thickness and size of left lobe of liver in morbidly obese patients in comparison with CT and operative findings
Authors: Abdelwahab Amr Abdalla , Nashed George Abdelfady , Elkafas Khaled Helmy , Abdelhakam Mahmoud Abdelazeem , Mahmoud Athar Samir
Published: October 2024

Background

Increased abdominal wall thickness and size of left lobe of liver affect the ergonomics of bariatric surgery increasing its difficulty and leading to need of special preparations such as extra-long instruments. Computed tomography (CT) abdomen is the gold standard modality in assessment of abdominal wall thickness and size of left lobe of liver, but it has many drawbacks such as radiation and contrast. In this study, we validate ultrasound as an alternative to CT by comparing its results with CT abdomen and operative findings.

Results

Abdominal ultrasound examination gives accurate results in assessment of anterior abdominal wall thickness and size of left lobe of liver in morbidly obese patients compared to CT and intra-operative with slight difference between values which is clinically accepted. Accuracy of ultrasound examination was 78.6%, 74.1%, and 100% for midline measurements, midclavicular line measurements and size of lt lobe of liver measurements, respectively. Ultrasound examination has sensitivity of 75%, 66.7% and 63.2% for midline measurements, midclavicular line measurements and size of lt lobe of liver measurements, respectively. Ultrasound examination specificity was 50%, 77.1% and 75.3% for midline measurements, midclavicular line measurements and size of lt lobe of liver measurements, respectively.

Conclusion

Abdominal ultrasound examination is a valid method in preoperative assessment of anterior abdominal wall thickness and size of left lobe of liver in morbidly obese patients. It is reliable, easy, and cheap and avoids drawbacks of CT.
A qualitative exploration of the implementation facilitators and challenges of a community health worker program to address health disparities for people recently released from incarceration using the consolidated framework for implementation research
Authors: Hood Quinn O. , Irvine Natalia , Shah Krina , Ali Shahmir H. , Mezzacca Tamar Adjoian , Serrano Michael , Thorpe Lorna E. , Huang Terry T. K. , Khan Maria R. , Islam Nadia
Published: October 2024

Background

Despite the potential for community health worker (CHW)-led programs to improve the health of people with justice involvement (PWJI), little is known about the practical implementation of such models. We explored barriers and facilitators to implementation of a municipal CHW program, the Health Justice Network (NYC HJN), led by the New York City Department of Health and Mental Hygiene (DOHMH) in partnership with three reentry-focused community-based organizations (CBOs) and three federally qualified health centers (FQHCs) that was designed to serve the health and social service needs of PWJI.

Methods

Eighteen in-depth qualitative interviews were conducted with a purposive sample of CHWs, partner site supervisors, and DOHMH staff. Interviews were conducted virtually and transcribed verbatim. Codes and themes were developed using the Consolidated Framework for Implementation Research (CFIR) to understand facilitators and barriers to NYC HJN implementation.

Results

Important facilitators to implementation included: lived experience of CHWs, as well as NYC HJN’s voluntary nature, lack of onerous eligibility criteria, and prioritization of participant needs. One barrier was the lack of a formal implementation protocol. Themes identified as facilitators in some instances and barriers in others were CHW integration into site partners, the expansive scope of work for CHWs, the integration of a trauma-informed approach, values alignment and existing infrastructure, leadership engagement, CHW training and support, and input, feedback, and communication.

Conclusions

Findings will help inform how to successfully implement future CHW-led interventions for PWJI with municipal, health, and social service partners.
Factors affecting time to recovery from diabetic ketoacidosis in adult diabetic patients in Alexandria Main University Hospital
Authors: Sabry Ahmed A. , Alkafafy Asmaa Mohamed , Morsy Eman Youssef , Aiad Ahmed , Montasser Mina
Published: October 2024

Background

Diabetic ketoacidosis (DKA) is a life-threatening condition as a complication of diabetes and represents a significant healthcare global burden. The current study goal was to determine factors affecting time to recovery from DKA in Alexandria Main University Hospital.

Patients and methods

One hundred fifty patients who had been admitted with DKA were included in this study. All patients were managed with hospitalization for IV fluids, continuous intravenous insulin infusion, electrolyte correction, as well as detection and treatment of the predisposing factor until the full resolution of DKA.

Results

Males contributed to 58.7% of the total patients in this study with a mean age of 32.16 ± 15.06 years. DKA mean time of resolution was 18.76 ± 14.07 h. The majority of patients were with T1DM (86%), while T2DM were 14%. Missed insulin dose was the leading precipitating factor (60.7%) followed by infections (38.7%). There was a statistically significant relationship between DKA resolution time with age, time of presentation, type of diabetes, initial pH, initial serum K+ level, initial HCO3− level, initial anion gap, initial base excess, and initial RBS (p value < 0.001).

Conclusion

Delayed time of resolution from DKA was associated with initial lower pH, initial lower HCO3− level, initial lower base excess level, initial higher anion gap level, type 2 diabetes mellitus, patients on pre-mixed insulin regimen, old patients, delayed time for seeking medical care, and abnormal serum K+ level.
Effectiveness of video-based teaching in surgery residents: A randomized control trial
Authors: Niaz Khurram , Mehboob Usman , Masood Darakhshan , Maqbool Ali
Published: October 2024

Objective: To determine the effectiveness of video-based teaching in surgery residents by comparing it to the routine operating room traditional teaching.
Methodology: The randomized control trial was done at four institutions from September 2022 to March 2023. Interventional group underwent video-based instruction of basic surgical skills whereas the control group was taught through traditional operating room teaching. Pre and post-test mean scores were analyzed on SPSS version 20 through paired t-test. Learning gain was calculated. Supervisors’ perceptions were recorded on survey form regarding direct observations and recorded video evaluations of resident skills on post-test.
Results: Out of sixty (n=60), fifty-five newly inducted surgical residents completed the study including both females (n=13) and male residents (n=42). Video intervention Group (27.93±3.72) and control group (23.07±4.62) both showed improvements in their post-test scores as compared to pretest scores of 13.68±3.25 and 13.52±3.60 respectively. Mean score difference improvement was more in video intervention group (13.9±3.8) in comparison to control group (9.5±4.3) provided both groups exhibits improvements in all seven domains of the global rating system (reflected by the p <0.0001). However, learning gain of 65% was observed in intervention group as compared to learning gain (41%) of control group. Evaluators(n=5) observed that recorded video evaluations helped to provide integrated feedback, despite being time (40%) and resource intensive (60%).
Conclusion: Video-based teaching has higher learning gain irrespective of the fact that both groups exhibit statistically significant results in all seven domains of the global rating system. Recorded video evaluation was found feasible and reliable tool for formative assessment.
doi: https://doi.org/10.12669/pjms.40.10.7856
How to cite this: Niaz K, Mahboob U, Masood D, Maqbool A. Effectiveness of video-based teaching in surgery residents: A randomized control trial. Pak J Med Sci. 2024;40(10):2373-2378. doi: https://doi.org/10.12669/pjms.40.10.7856
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Influence of spin-off decision on financing risk: Empirical insight from Indonesian Islamic banks
Authors: Pambuko Zulfikar Bagus , Sriyana Jaka , Affandi Akhsyim , Hakim Abdul
Published: October 2024

Background Spin-offs play a significant role in organizational development strategies, particularly in Islamic banking, by fostering entrepreneurship, innovation, and Shariah-compliant management practices. Indonesia stands as a pioneer in implementing the dual banking system and has established a spin-off policy to foster the growth of Islamic banking. This study investigates whether the spin-off decision has a significant impact on financing risk in Indonesian Islamic banks. Methods Financing risk is measured by the non-performing financing ratio, while the spin-off decision is represented by a dummy variable equal to 1 for the post-spin-off period and 0 for the pre-spin-off period. This study utilizes data from semi-annual reports of 35 Indonesian Islamic banks and analyzes it using a dynamic panel model with the Generalized Method of Moments (GMM). Results The findings reveal that spin-offs significantly reduce financing risk, thereby enhancing the financial resilience and boosting investor appeal. Notably, this implies that Islamic banks operating as Islamic windows exhibit a higher level of financing risk compared to fully-fledged Islamic banks. Furthermore, a noteworthy pattern emerges that spin-off Islamic banks with substantial assets demonstrate greater risk in comparison to their counterparts with more modest assets. System GMM also confirmed the result. Conclusions Islamic banks can significantly reduce their financing risks by establishing independent Islamic banks, or spin-offs. Unlike Islamic windows, which are typically integrated within conventional banks and face higher risk levels, standalone Islamic banks offer greater flexibility and control over their operations.
Simulated data for census-scale entity resolution research without privacy restrictions: a large-scale dataset generated by individual-based modeling
Authors: Haddock Beatrix , Pletcher Alix , Blair-Stahn Nathaniel , Keyes Os , Kappel Matt , Bachmeier Steve , Lutze Syl , Albright James , Bowman Alison , Kinuthia Caroline , Burke-Conte Zeb , Mudambi Rajan , Flaxman Abraham
Published: October 2024

Background Entity resolution (ER) is the process of identifying and linking records that refer to the same real-world entity. ER is a fundamental challenge in data science, and a common barrier to ER research and development is that the data fields used for this fuzzy matching are personally identifiable information, such as name, address, and date of birth. The necessary restrictions on accessing and sharing these authentic data have slowed the work in developing, testing, and adopting new methods and software for ER. We recently released pseudopeople, a Python package that allows users to generate simulated datasets with configurable noise approaching the scale and complexity of the data on which large organizations and federal agencies, like the US Census Bureau regularly perform ER. With pseudopeople, researchers can develop new algorithms and software for ER of US population data without needing access to personal and confidential information. Methods We created the simulated population data available for noising with pseudopeople using our Vivarium simulation platform. Our model simulates individuals and their families, households, and employment dynamics over time, which we observe through simulated censuses, surveys, and administrative data collection systems. Results Our simulation process produced over 900 gigabytes of simulated censuses, surveys, and administrative data for pseudopeople, representing hundreds of millions of simulants. A sample simulated population of thousands of simulants is now openly available to all users of the pseudopeople package, and large-scale simulated populations of millions and hundreds of millions of simulants are also available by online request through GitHub. These simulated population data are structured for use by the pseudopeople package, which includes additional affordances to add various kinds of noise to the data to provide realistic, sharable challenges for ER researchers.
European agrifood and forestry education for a sustainable future - Gap analysis from an informatics approach
Authors: Burleigh Stephen , Jönsson Håkan
Published: October 2024

Background The NextFood Project (www.nextfood-project.eu) started work in 2018 to identify ‘Categories of Skills’ that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking. This study is based on the initial skills and competencies mapping, but takes a different methodological approach. Instead of investigating what the research literature and professionals think are important skills for the future, this study asks how existing education programmes include or exclude these skills in the description of their programs. Methods Python-based web-scraping scripts were used to collect texts from a selection of European Masters program websites, which were then analysed using statistical tools. A total of 14 countries, 27 universities, 1303 European Masters programs, 3305 web-pages and almost two million words were studied using this approach. Results While agrifood and forestry Masters programs were aligned with the NextFood Project ‘Categories of Skills’ equal to or more often than unrelated Masters programs, we found evidence for the relative underuse of words associated with networking skills, such as 舖collaboration舗, 舖communication舗 and 舖teamwork舗. Agriculture-related programs used these words the least among the agrifood Masters programs. In contrast, agrifood programs used words associated with sustainability and system thinking more than the non-agrifood Masters programs. Conclusions The informatics approach provides evidence that many European agrifood and forestry Masters programs are following the educational paths for meeting future challenges as outlined by the NextFood Project, with the possible exception of networking skills. This approach allows a complementary and time-efficient overview of the current state of education in the agrifood system in Europe.
Targeting deeply-sourced seeps along the Central Volcanic Zone
Authors: Bastoni Deborah , Aguilera Mauricio , Aguilera Felipe , Blamey Jenny M. , Buongiorno Joy , Chiodi Agostina , Cordone Angelina , Esquivel Alfredo , Giardina Marco , Gonzalez Cristobal , Gutierrez Joaquin , Irarrazabal Nahun , Krukenberg Viola , Layana Susana , Pasotti Jacopo , Ramirez Carlos J. , Rodriguez Alejandro , Rogers Timothy J. , Rojas Claudia , Sánchez-SanMartín Jorge , Schrenk Matt O. , Vallejos Hector , Jessen Gerdhard L. , Barry Peter H. , de Moor J. Maarten , Lloyd Karen G. , Giovannelli Donato
Published: October 2024

At convergent margins, plates collide producing a subduction process. When an oceanic plate collides with a continental plate, the denser (i.e., oceanic) plate subducts beneath the less dense (continental) plate. This process results in the transportation of carbon and other volatiles into Earth’s deep interior and is counterbalanced by volcanic outgassing. Sampling deeply-sourced seeps and fumaroles throughout a convergent margin allows us to assess the processes that control the inventory of volatiles and their interaction with the deep subsurface microbial communities. The Andean Convergent Margin is volcanically active in four distinct zones: the Northern Volcanic Zone, the Central Volcanic Zone, the Southern Volcanic Zone and the Austral Volcanic Zone, which are each characterised by significantly different subduction parameters like crustal thickness, age of subduction and subduction angle. These differences can change subduction dynamics along the convergent margin, possibly influencing the recycling efficiency of carbon and volatiles and its interaction with the subsurface microbial communities. We carried out a scientific expedition, sampling along a ~800 km convergent margin segment of the Andean Convergent Margin in the Central Volcanic Zone of northern Chile, between 17 °S and 24 °S, sampling fluids, gases and sediments, in an effort to understand interactions between microbiology, deeply-sourced fluids, the crust, and tectonic parameters. We collected samples from 38 different sites, representing a wide diversity of seep types in different geologic contexts. Here we report the field protocols and the descriptions of the sites and samples collected.
Investigating light sensitivity in bipolar disorder (HELIOS-BD)
Authors: Roguski Amber , Needham Nicole , MacGillivray Tom , Martinovic Jasna , Dhillon Baljean , Riha Renata L. , Armstrong Lyle , Campbell Iain H. , Ferguson Amy , Hilgen Gerrit , Lako Majlinda , Ritter Philipp , Santhi Nayantara , von Schantz Malcolm , Spitschan Manuel , Smith Daniel J.
Published: October 2024

Many people with bipolar disorder have disrupted circadian rhythms. This means that the timing of sleep and wake activities becomes out-of-sync with the standard 24-hour cycle. Circadian rhythms are strongly influenced by light levels and previous research suggests that people with bipolar disorder might have a heightened sensitivity to light, causing more circadian rhythm disruption, increasing the potential for triggering a mood switch into mania or depression. Lithium has been in clinical use for over 70 years and is acknowledged to be the most effective long-term treatment for bipolar disorder. Lithium has many reported actions in the body but the precise mechanism of action in bipolar disorder remains an active area of research. Central to this project is recent evidence that lithium may work by stabilising circadian rhythms of mood, cognition and rest/activity. Our primary hypothesis is that people with bipolar disorder have some pathophysiological change at the level of the retina which makes them hypersensitive to the visual and non-visual effects of light, and therefore more susceptible to circadian rhythm dysfunction. We additionally hypothesise that the mood-stabilising medication lithium is effective in bipolar disorder because it reduces this hypersensitivity, making individuals less vulnerable to light-induced circadian disruption. We will recruit 180 participants into the HELIOS-BD study. Over an 18-month period, we will assess visual and non-visual responses to light, as well as retinal microstructure, in people with bipolar disorder compared to healthy controls. Further, we will assess whether individuals with bipolar disorder who are being treated with lithium have less pronounced light responses and attenuated retinal changes compared to individuals with bipolar disorder not being treated with lithium. This study represents a comprehensive investigation of visual and non-visual light responses in a large bipolar disorder population, with great translational potential for patient stratification and treatment innovation.
The genome sequence of the oak pinhole borer, Platypus cylindrus (Fabricius, 1792)
Authors: Barclay Maxwell V. L. , Vassiliades Danaë , Bayfield Farrell Will , Cristóvão Joana , Matsumoto Keita , Geiser Michael , Telfer Mark G. ,   Natural History Museum Genome Acquisition Lab,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: October 2024

We present a genome assembly from an individual male Platypus cylindrus (the oak pinhole borer; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 147.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,468 protein coding genes.
The genome sequence of common vervain, Verbena officinalis L. (Verbenaceae)
Authors: Christenhusz Maarten J. M. , Leitch Ilia J. , Márquez-Corro José Ignacio ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Plant Genome Sizing collective,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: October 2024

We present a genome assembly of a specimen of common vervain, Verbena officinalis (Streptophyta; Magnoliopsida; Lamiales; Verbenaceae). The genome sequence has a total length of 289.20 megabases. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 495.81 kilobases and 153.46 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 25,194 protein-coding genes.
Information Disclosure and Competitive Dynamics: Evidence from the Pharmaceutical Industry
Authors: Kao Jennifer
Published: October 2024

This paper studies how competitive dynamics shape innovative firms’ voluntary disclosure of product quality information. Our empirical context is the pharmaceutical industry, where firms must decide whether to disclose private drug quality information acquired in clinical trials. Using a difference-in-difference strategy, we show that the approval of a competitor’s drug lowers the likelihood of a firm reporting its clinical trial results by 13%. We explore how these effects vary based on the project quality, competitor type, and firm experience. These findings suggest that strategic considerations play a role in firms’ disclosure decisions; in response to a competitor’s drug approval, firms may selectively withhold information to maintain and improve their competitive position.

This paper was accepted by Joshua Gans, business strategy.

Funding: This work was funded by the National Institute on Aging [Grant T32-AG000186] and the UCLA Society of Hellman Fellows Program.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01161 .
Exploring the patients’ and family members’ perspectives on home-based palliative care
Authors: Mushtaq Nadia Sultanali
Published: October 2024

Background:

Healthcare at home is considered a partial substitute for institutional long-term care, because patients and families with known poor prognoses prefer to stay home with their loved ones and are unable to pay for hospital care at the end of life in some countries.

Purpose:

To explore patients’ and family members’ perspectives and experiences of receiving home-based palliative care services.

Method:

This was a qualitative exploratory study conducted in Karachi, targeting patients and family members receiving home-based palliative care services. The data collection was done via interviews, and simultaneously, the interviewer recorded field notes, which were all carried out within the confines of the participants’ homes. Moreover, the subjects were recruited through purposive sampling, resulting in a total of six patients and six family members. The final number of participants was determined based on data saturation. The inclusion criteria encompassed individuals of all genders, aged 18 and above, and residents of Karachi, Pakistan. Those who were not able to provide information, due to any reason, were excluded from the study. The study adhered strictly to ethical considerations.

Findings:

The study uncovered several significant themes that provide valuable insights, including caregivers’ availability, patients’ inclusiveness, improved dietary pattern, psychological wellbeing, and rapid recovery in home-based care. Furthermore, the study identified themes on providing home-based palliative care, like family members’ education and keeping back-ups for unforeseen situations. In contrast, the themes identified as home-based care preference over hospital care were: experienced compromised care, hospital anxiety, restricted to the available resources and higher hospital living expenses for patients and family members.

Conclusion:

The study underscored the importance of adopting a patient-centric approach. It has become evident that the comfort and familiarity of one’s home environment provide a conducive backdrop for holistic healing and wellbeing.
Study of the resistance to quaternary Ammonium-based disinfectants in Escherichia coli and Staphylococcus aureus strains carrying third-generation cephalosporin resistance
Authors: Fait Sofia , Bencaid Khaoula , Elkhattabi Lamiae , Timinouni Mohammed , Roqai Mhammed Chaoui
Published: October 2024

Multidrug-resistant bacteria pose a significant public health challenge, with the effectiveness of biocides in their eradication proving occasionally inadequate. This ineffectiveness highlights concerns over the potential correlation between biocide utilization and the rise in antibiotic resistance. Accordingly, this study is designed to examine the effectiveness of specific quaternary ammonium compound-based disinfectants against Escherichia coli and Staphylococcus aureus strains that are resistant to third-generation cephalosporins, particularly CTX-M type. The evaluation is based on performing antibiograms, followed by subjecting these strains to escalating concentrations of disinfectants with quaternary ammonium components. Additionally, the study involves screening for resistance genes to deepen our understanding of these resistance mechanisms. The outcomes revealed that the strains under scrutiny were resistant to a multitude of antibiotics. The Escherichia coli strains in question also displayed markedly reduced susceptibility to the biocides being studied. Conversely, the Staphylococcus aureus strains were inhibited at notably low concentrations of biocides. Notably, the qacΔE1 gene was detected in two Escherichia coli strains. We have identified instances of cross-resistance between certain disinfectants and antibiotics. Specifically, certain E. coli strains demonstrated diminished susceptibility to the first biocidal agent. This resistance was supported by the presence of the qacΔE1 gene in these same strains.
MetaMax: an objective-sized instrument for advanced light microscope characterization and empirical metadata collection.
Authors: Flemming Selene , Grunwald David
Published: October 2024

MetaMax is a device designed to replace the objective lens in light microscopes and provide a wide range of experimental metadata that characterize microscope performance. MetaMax includes a large-area photodiode that is referenced against calibrated power meters to measure excitation light power and source stability; a broadband LED to quantify detector system responsivity and signal-dependent noise; a spectrometer to identify excitation wavelengths; an adjustable iris to simulate an objective’s back aperture; and a quadrant photodiode to assess beam alignment and aperture overfill. MetaMax enables users to collect performance data for both quality control and comprehensive acquisition metadata. It simplifies access to performance data that typically requires expert knowledge and expensive equipment to obtain, lowering the access barrier for users. Such performance data is crucial for improving the reliability and reproducibility of microscopy images. The MetaMax aims to facilitate collaboration through data reusability, and promote a more rigorous, transparent approach to scientific inquiry using light microscopy techniques. This work presents a detailed evaluation and comparison of several MetaMax prototypes.
High spectral-efficiency, ultra-low MIMO SDM transmission over a field-deployed multi-core OAM fiber
Authors: Liu Junyi , Mo Shuqin , Xu Zengquan , Huang Yuming , Huang Yining , Li Zhenhua , Guo Yuying , Shen Lei , Xu Shuo , Gao Ran , Du Cheng , Feng Qian , Luo Jie , Liu Jie , Yu Siyuan
Published: October 2024

Space-division multiplexing (SDM) systems based on few-mode multi-core fibers (FM-MCFs) utilize both spatial channels (fiber cores) and modes (optical modes per core) to maximize transmission capacity. Unlike laboratory FM-MCFs or field-deployed single-mode multi-core fibers (SM-MCFs), SDM transmissions over field-deployed FM-MCFs in outdoor settings have not been reported. Therefore, concerns remain that environmental interference and cabling stress could worsen inter-core and intra-core modal crosstalk and impact the performance of SDM systems over FM-MCFs. In this paper, we demonstrate successful bidirectional SDM transmission over a 5-km, field-deployed seven ring-core fiber (7-RCF) with a cladding diameter of 178 μm. Our measurements show no significant differences in attenuation and mode coupling compared to pre-cabling conditions, confirming the fiber’s resilience to environmental disturbances and adaptability to cable deployment. Using the field-deployed 7-RCF, bi-directional SDM transmission is implemented, achieving spectral efficiency (SE) of 2×201.6 bit/(s Hz) which sets a new record in field-deployed fiber cables that is a tenfold increase over previous systems. Furthermore, these results were achieved using a small-scale 4×4 multiple-input multiple-output (MIMO) scheme with a time-domain equalization (TDE) tap number not exceeding 15. These results demonstrate the substantial potential of using SDM techniques to significantly enhance SE and expand capacity in practical fiber-optic transmission applications.
The economic cost of malaria in Brazil from the perspective of the public health system
Authors: Andrade Mônica V. , Noronha Kenya , Silva Valéria , Bracarense Henrique , Carvalho Lucas , Silva Daniel Nogueira da , Souza Aline , Motta-Santos André Soares , Peterka Cassio , Castro Marcia C.
Published: October 2024

This paper presents an economic evaluation aimed at estimating malaria-related health care expenditures in Brazil from the perspective of the public health system. Comprehensive estimates of the costs of malaria remain scarce, in part because of limited data. Brazil has a universal health system (Sistema Único de Saúde-SUS) in which all cases of malaria are diagnosed and treated. In addition, antimalarial drugs are only available through the SUS. We compiled comprehensive data from multiple administrative sources. Expenditure indicators were calculated for municipalities and states in the Brazilian Amazon, a region where more than 99% of the country’s malaria cases are concentrated. We also developed a digital platform that allows interactive visualization of the malaria cost indicators, disaggregated by cost type and geography. Our results show that control and prevention activities are the primary cost in all states, followed by human resources and disease treatment. Expenditures per malaria notification in the Amazon ranged from PPP (purchasing power parity)-US$59.00 (2017) to PPP-US$77.00 (2016), while per capita expenditures remained relatively stable at around PPP-US$3.50. The malaria cost estimates presented here contribute to a better negotiation of the financial resources needed by the NMCP and are one of the critical pieces of information for a strategic plan of activities needed to achieve the elimination goal.
The relationship between leadership and adaptive performance: A systematic review and meta-analysis
Authors: Bonini Alice , Panari Chiara , Caricati Luca , Mariani Marco Giovanni
Published: October 2024

This research presents a comprehensive review and meta-analysis of literature to examine the impact of various leadership styles on organizational adaptive performance (AP). AP is essential for job performance, especially in environments undergoing rapid changes. Previous reviews on AP found that transformational and self-leadership had had a positive influence on job adaptivity, while the relationship between other leadership styles and AP had not been clear. First, authors outlined the theoretical framework of AP and leadership, clarifying how job adaptivity and the different leadership styles are defined and discussed in the scientific literature. Subsequently four scientific databases were explored to identify studies that investigate the Leadership and AP’ relationship. 32 scientific articles and 2 conference papers were investigated for review, of which 31 were used to conduct a meta-analysis; 52 different effect sizes from 32 samples were identified for a total sample size of 11.640 people. Qualitative synthesis revealed that the influence of different leadership styles on AP depended on contextual variables and on aspects related to the nature of the work. Moreover, it was found that leadership supported AP through motivational and relational aspects. Through this meta-analysis, it was found that a significant positive relationship between leadership and AP existed (Zr = .39, SE = .04, p < .001. 95%CI [.32, .47], r = .37). However, no differences emerged from the different leadership styles examined in the studies. This review deepens the importance of leadership as organizational factor that affect the employees’ likelihood of dealing with continuously emergent changes at work, extended the search to emerging leadership approaches to highlight the value of collective contributions, ethics, and moral and sustainable elements that could positively affect AP.
Predicting the volatility of Chinese stock indices based on realized recurrent conditional heteroskedasticity
Authors: Zhang Gongtao , Zhao Huanyu , Fan Rujie
Published: October 2024

The realized recurrent conditional heteroscedasticity (RealRECH) model improves volatility prediction by integrating long short-term memory (LSTM), a recurrent neural network unit, into the realized generalized autoregressive conditional heteroskedasticity (RealGARCH) model. However, at present, there is no literature on the ability of the RealRECH model to fit and predict volatility in the Chinese market. In this paper, a study is conducted to test the in-sample explainability and out-of-sample prediction ability of the RealRECH model for the SSE50, CSI300, CSI500 and CSI1000 indices in the Chinese market and to determine whether it performs better than the RealGARCH model. The results of the in-sample analysis show that the RealRECH model not only provides better in-sample interpretability for all four indices but also captures the complex dynamics of time series volatility that the RealGARCH model cannot capture, such as long-term dependence and nonlinearity. The results of out-of-sample volatility prediction show that the RealRECH model better predicts the volatility of the CSI500 and CSI1000 indices but yields worse predictions for the SSE50 and CSI300 indices. Thus, the RealRECH model can be used for CSI500 and CSI1000 prediction.