bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating and Enhancing the Fitness-for-Purpose of Electronic Health Record Data: Qualitative Study on Current Practices and Pathway to an Automated Approach Within the Medical Informatics for Research and Care in University Medicine Consortium (Preprint)
Authors: Kamdje Wabo Gaetan , Moorthy Preetha , Siegel Fabian , Seuchter Susanne A , Ganslandt Thomas
Published: February 2024

BACKGROUND

Leveraging electronic health record (EHR) data for clinical or research purposes heavily depends on data fitness. However, there is a lack of standardized frameworks to evaluate EHR data suitability, leading to inconsistent quality in data use projects (DUPs). This research focuses on the Medical Informatics for Research and Care in University Medicine (MIRACUM) Data Integration Centers (DICs) and examines empirical practices on assessing and automating the fitness-for-purpose of clinical data in German DIC settings.

OBJECTIVE

The study aims (1) to capture and discuss how MIRACUM DICs evaluate and enhance the fitness-for-purpose of observational health care data and examine the alignment with existing recommendations and (2) to identify the requirements for designing and implementing a computer-assisted solution to evaluate EHR data fitness within MIRACUM DICs.

METHODS

A qualitative approach was followed using an open-ended survey across DICs of 10 German university hospitals affiliated with MIRACUM. Data were analyzed using thematic analysis following an inductive qualitative method.

RESULTS

All 10 MIRACUM DICs participated, with 17 participants revealing various approaches to assessing data fitness, including the 4-eyes principle and data consistency checks such as cross-system data value comparison. Common practices included a DUP-related feedback loop on data fitness and using self-designed dashboards for monitoring. Most experts had a computer science background and a master’s degree, suggesting strong technological proficiency but potentially lacking clinical or statistical expertise. Nine key requirements for a computer-assisted solution were identified, including flexibility, understandability, extendibility, and practicability. Participants used heterogeneous data repositories for evaluating data quality criteria and practical strategies to communicate with research and clinical teams.

CONCLUSIONS

The study identifies gaps between current practices in MIRACUM DICs and existing recommendations, offering insights into the complexities of assessing and reporting clinical data fitness. Additionally, a tripartite modular framework for fitness-for-purpose assessment was introduced to streamline the forthcoming implementation. It provides valuable input for developing and integrating an automated solution across multiple locations. This may include statistical comparisons to advanced machine learning algorithms for operationalizing frameworks such as the 3×3 data quality assessment framework. These findings provide foundational evidence for future design and implementation studies to enhance data quality assessments for specific DUPs in observational health care settings.
Evaluation of Dry Density for Black Cotton Soil Using Rice Husk Ash
Authors: Yadav Koushlandra
Published: February 2024

Abstract: Stabilization is a broad term that refers to the various methods used to improve the engineering performance of a soil and its application in a variety of engineering works. Soil stabilisation is a major concern for civil engineers today, both for road construction and for increasing soil strength or stability, which reduces construction costs. Soil stabilisation is the chemical or physical modification of soil properties to improve the soil's engineering quality. The primary goal of soil stabilisation is to increase the soil's bearing capacity, resistance to weathering processes, and permeability. Due to the rapid growth of urbanization and industrialization, minimizing industrial waste. Because of the rapid growth of urbanization and industrialization, reducing industrial waste has become a major issue in recent years. To encounter this innovative and nontraditional research on waste utilization is becoming increasingly important. Soil improvement using waste materials such as slags, rice husk ash, and silica fume has been recommended from an environmental standpoint in geotechnical engineering. This paper examines the effects of blast furnace slag, fly ash, and micro silica added to black cotton soil to improve soil properties. In addition, this paper provides a review of the use of various solid waste materials for soft soil stabilisation. However, there are numerous methods and techniques available for stabilising these soils. This study describes how waste materials can be used to stabilise soft soil
Implementation of High Speed and Area Efficient Polar Encoder
Authors: Usha Dr. K. , Kulkarni Dr. Vibha D.
Published: February 2024

Abstract: Polar codes were introduced by E.Arıkan in 2008. They are the first family of error-correcting codes that attain the capacity of binary memoryless and symmetric channels with efficient encoding, decoding, and construction algorithms. In this paper, implementation of high speed and area efficient polar encoder for systematic polar codes is presented. According to an iterative property of the generator matrix and particular lower triangular structure of the matrix, the number of XOR computations are reduced. In this implementation, total area of the encoder is decreased by 33.69%, delay is decreased by 54.6% and power consumption is decreased by 39.44%.
Impact and Trends of Climate Change Analysis of Streamflow at Various Gauging Stations in the Jhelum River, Jammu & Kashmir
Authors: Pandit Dr. Bashir Ahmad
Published: February 2024

Abstract: The planet Earth's water resources are involved in the biggest matter movement in the Earth's system, the hydrological cycle, which is infinitely repeated. Given that water is the fundamental component of the planet's life support system, it is critical to comprehend how current and anticipated climate change is affecting water availability and supplies. Stream flow trend analysis is crucial for flood forecasting and hydrologic drought assessment-related research, in addition to the study of water resource management. This study examined the long-term variations in stream flow at several gauging stations in the Jhelum River of Jammu and Kashmir . The Modified Mann-Kendall Test was used to analyze trends (MMKT). Sen's Slope Estimator (SSE) was employed in order to quantify trend. Trend analysis was performed using long-term time series data of the monthly and annual maximum stream flows at 10 gauging stations. The streamflow annual timeseries was not visible. any discernible upward or downward trends at any gauging point. Nonetheless, it was discovered that every noteworthy trend discovered at several gauging sites over the course of several seasons was declining in character. Throughout July, six gauging sites showed tendencies of declining streamflow. However, in addition to helping with regional hydrologic studies, this kind of river water flow research would also be helpful for studying the occurrence of floods and hydrologic droughts.
The Influence of Music Genres on Fashion Styles; a Cross-Culture Analysis on Youngsters
Authors: R Harshika , Nag Shashi
Published: February 2024

Abstract: This study roots into the complex relationship between music and fashion, aiming to reveal the significant impact of music on the continually changing fashion industry. It has long been acknowledged that music, as a potent cultural force, can influence social conventions, feelings, and manifestations. In a similar vein, fashion conveys identity, culture, and inventiveness through its visual language. This research attempts to clarify the mutually beneficial link between these two artistic mediums by investigating the ways in which music both actively influences and reflects fashion trends over time. The study takes an interdisciplinary approach, tracing the dynamic relationships between music and fashion through historical investigations, cultural studies, and sociological viewpoints. We examine how genres and subcultures make a lasting impression on fashion choices through case studies that range from the rebellious styles of the 1950s rock 'n' roll era to the avant-garde fusions of modern pop and hip-hop influences. The study looks at how celebrities, from present influencers like Rihanna to historical icons like Elvis Presley, become fashion trendsetters and change agents. The research also explores the psychological and emotional aspects of this link, looking at how design decisions, colour schemes, and even the general public's definition of beauty are influenced by the beat, lyrics, and spirit of music. The goal of the paper is to present a thorough understanding of the mutual effect between music and fashion, illuminating the processes by which cultural change is manifested visually. In summary, this study adds to the expanding literature of research examining the relationship between fashion and music, providing insights into the processes that influence fashion and stimulate innovation. Comprehending this mutually beneficial association enhances our admiration for both artis
Effect of edaphic silicon on the quality and postharvest of ‘Dorado’ peach (Prunus persica) fruits
Authors: Álvarez-Herrera Javier Giovanni , Molano-Diaz Julian Mauricio , Camacho-Torres Yenny Maritza
Published: February 2024

In recent years, Colombia has seen an increase in the demand for peach fruits, but despite having adequate areas for peach production, neither production nor quality has increased because these fruits have a short post-harvest life and low firmness, which makes them susceptible to manipulation. The nutritional element Silicon affects the quality of these fruits when applied in fertilization, increasing firmness values, improving color, and favoring the concentration of metabolites. Therefore, the objective was to evaluate the edaphic application of different doses of silicon in the postharvest behavior of 'Dorado' peach fruits to maintain quality during storage for a longer time. A completely randomized block design with two blocks (stratum 1 and stratum 2) and five treatments (0, 300, 600, 900, or 120 kg ha-1 of silicon) was evaluated. The fruits from plants fertilized with 1200 kg ha-1 of Si showed more firmness and total soluble solids (TSS); however, the application of Si did not affect the other parameters. Fruits from stratum 1 had higher firmness and TSS than those from stratum 2, while the total carotenoids were not affected by stratum. The total titratable acidity and luminosity of the fruits decreased during postharvest, while the TSS only showed a slight increase. The respiratory rate presented the highest value ​​at 11 days of storage.
A importância dos grupos de pesquisa para a legitimação e consolidação da Comunicação Ambiental no Brasil
Authors: da Costa Bueno Wilson
Published: February 2024

A pesquisa realizada junto ao Diretório dos Grupos de Pesquisa do CNPq resgatou os grupos de pesquisa em Comunicação Ambiental no Brasil, que foram categorizados a partir de inúmeros fatores (data de fundação, constituição, vínculos institucionais, linhas de pesquisa e perfil dos líderes dos grupos, sua formação e produção na área). Os dados obtidos na investigação, de caráter prioritariamente quantitativo, evidenciaram a importância destes grupos na produção e disseminação de informações qualificadas, permitindo concluir que eles contribuem para subsidiar a construção de políticas públicas, bem como para a formação de professores, pesquisadores e profissionais da área ambiental.
Ação comunicativa e democracia: por uma política deliberativa em Jürgen Habermas
Authors: Cordeiro da Costa Oliveira Juliano
Published: February 2024

A presente obra reconstroi aquilo que poderíamos chamar de uma Filosofia Política de Jürgen Habermas. O filósofo alemão parte da Teoria da Ação Comunicativa como referência para suas reflexões. A descoberta da linguagem como médium intransponível de todo sentido, de toda reflexão teórica e prática, forçou um repensamento de todos os problemas filosóficos. Agora, normas racionais nascem da práxis dialógica dos sujeitos envolvidos numa determinada situação. A razão comunicativa, para Habermas, é a única que tem condições de fundamentar normas num mundo marcado pela pluralidade de visões de vida. Ele, então, a partir da ação comunicativa, elabora o conceito de política deliberativa, realizando uma síntese entre o liberalismo e o republicanismo. Há, na teoria de Habermas, uma conciliação entre a autonomia privada e a pública, entre os direitos humanos e a soberania popular, entre a liberdade dos modernos e a dos antigos. Segundo Habermas, não há um privilégio da política a ser realizada no âmbito da sociedade civil, como no republicanismo, ou exclusivamente no sistema político, como nas teorias liberais. Os sujeitos serão autônomos à medida que puderem se entender também como autores do direito ao qual se submetem enquanto destinatários numa democracia.
Health Literacy of the Inhabitants of easter Slovakia regarding Disease of Civilization – survey Results
Authors: Belovicova M. , Jankelova N. , Dostalova K. , Jankelova N. , Moricova S.
Published: February 2024

Introduction: Diseases of civilization represent a group of diseases that have common risk factors as a result of long-term exposure to an unhealthy lifestyle, an unhealthy diet, smoking, a lack of physical activity and stress. Aim of the research: To find out whether random respondents who took part in the “Days of Health” event at the Bardejov Spa have basic knowledge about diseases of civilization. Based on the findings, draw recommendations for practice. Research sample group: 398 respondents: 305 women and 93 men. The average age of the respondents was 56.4 years (+-12.8 years). Methodology: On a voluntary and anonymous basis, the patients filled out a questionnaire focused on their knowledge about diseases of civilization. The questionnaire contained both closed and open questions. Results: The authors of the article analyzed respondents’ answers. The results were statistically processed. Conclusion: Our results show that there is a need for repeated interventions by health care workers (doctors, nurses) and public health workers to spread awareness about diseases of civilization and the possibility of their prevention. Increasing the level of health literacy is a good prerequisite for a healthier population.
MAN IN SPACE AND SPACE IN MAN OR A HYDRO-MECHANICAL ANALOGY OF THE STREAMS OF LIFE
Authors: Dobrocheev O. V. , Lidzhiev D. N.
Published: February 2024

Based on the analysis of experimental data on the dynamics of a person’s physical condition and the activity of his organs, an extended interpretation of Kolmogorov’s hydrodynamic analogy is proposed. A satisfactory description by this physical model of the wave processes of life, starting from biological and ending with historical, creates a theoretical basis for its wide application in various branches of knowledge.
REFLECTIONS ON THE NATURE AND ESSENCE OF INFORMATION
Authors: Nadiradze A. B.
Published: February 2024

The article attempted to define the concept of “information,” based not on the observed properties of information, but on physical ideas about the nature of information processes. We considered questions about why information is needed, how new information arises, where and how it is stored, how information is exchanged between complex systems, and what knowledge is from an information point of view. The mechanisms for the emergence of knowledge in humans and the role of the subconscious in this process are discussed.
Diseño de una planta para la producción de bolsas oxo biodegradables, en la ciudad de Ocaña, Norte de Santander
Authors: Quintero Quintana Magdala Anyelith , Zambrano Cortés Lida Margarita , Molina Arévalo Natalia
Published: February 2024

This article presents the design of a plant for the production of oxo-biodegradable bags in the city of Ocaña, Norte de Santander, with the aim of reducing the environmental impact generated by plastic bags in the municipality. A market study is conducted to characterize plastic bag consumers and establish demand. In this particular case, customers are focused on the marketplace, retail supermarkets, and plastic bag distribution establishments. Based on customer preferences, the product design (capacity and type of bag) is developed, along with technical specifications and a generic logo. The design of the production process is carried out using the BPMN (Business Process Model and Notation) modeling technique, outlining each phase of production. Simultaneously, a systemic focus matrix is designed, showing the inputs, activities, and outputs of the process. The plant's layout design applies the SLP (System Layout Planning) method, illustrating the arrangement of workstations through the plant floor plan for production, thus observing the flow of materials. For the final design, 3D design software is used to visualize the area, layout, and dimensions of the plant.
Spatially Varying Covariate Model: A Hierarchical Bayesian Framework for Precipitation Frequency Analysis in the Gulf Coast
Authors: Lu Yuchen , Lee Benjamin Seiyon , Doss-Gollin James
Published: February 2024

Precipitation exceedance probabilities play a critical role in
engineering design, risk assessment, and floodplain management. While
climate variability and change impact the frequency and intensity of
heavy rainfall, the assumption that extreme precipitation is stationary
in time, as implemented in official guidance like Atlas 14, can
underestimate present and future hazards. Previous studies show that
conditioning the statistical distribution parameters on time-varying
climate covariates can improve estimates of nonstationary precipitation
frequencies. However, this approach increases the number of parameters
to be estimated, exacerbating parametric uncertainty. To address this,
we propose a nonstationary and spatially varying model for
process-informed precipitation frequency analyses. Specifically, we
assume that the robust effects of climate covariates on the probability
distribution of extreme rainfall are heterogeneous in space. We employ a
hierarchical Bayesian model, leveraging Gaussian processes and extreme
value theory, and apply this model to infer nonstationary rainfall
exceedance probabilities for the Western Gulf Coast. The proposed
approach is highly flexible, naturally allows the use of stations with
incomplete observational records, identifies robust temporal trends
along with smooth return level estimates, and quantifies parametric
uncertainty. This framework can be used to improve adaptation guidance
(such as IDF curves) in other regions.
Attempts at spatial analyses of data from the Polish Archaeological Record
Authors: Solecki Rafał , Smereczyńska Patrycja
Published: February 2024

Since the mid-1970s, the Polish Archaeological Record has been a national program in Poland with the primary objective of cataloguing archaeological sites, providing detailed descriptions and exact geographical locations. It is in operation to this day. So far, approximately 90% of the area of Poland has been prospected and almost 470,000 archaeological sites catalogued. Currently, work is underway to digitise the entire database. This paper presents our attempts to use the digitised data from this database to study the intensity of settlement processes in the past as well as how to visualise these data on a map. For the purpose of this research, archaeological data from an area in the northeast of Poland were digitised in a GIS environment. Examples of similar spatial analyses were taken from Scottish and Czech research and adapted to this case. The results, a series of maps showing the intensity of traces of human habitation in different time periods, demonstrate the strengths and weaknesses of such visualisations.
Analyzing Foramen Ovale Morphometrically in Adult Dry Skulls of Nigerian-Based Population
Authors: OO Godswill
Published: February 2024

Introduction: The foramen ovale is one of the major foramina on the greater wing of the sphenoid that is used for advanced surgical therapeutic and diagnostic procedures pertaining to the middle cranial fossa. The study was aimed at determining the length and width of foramen ovale in a Nigerian population. Materials and Methods: Seven dehydrated adult skulls, all the same gender, were acquired from the anatomy departments of Achievers University in Owo and Delta State University in Abraka, Nigeria. The length and the width of the foramen ovale were measured using digital sliding calipers. The paired sample t-test was used for the analysis. Results: The mean length of the foramen ovale was 0.611±0.21cm on the right side, and 0.42±0.12cm on the left side. The mean width was 0.5±0.15cm on the right side, and 0.43±0.12cm on the left side. Conclusion: Understanding the dimensions of the foramen ovale vary is crucial for neurosurgery during invasive surgical procedures like percutaneous trigeminal rhizotomy, as well as for biopsying Meckel cave lesions and cavernous sinus tumors.
Pleomorphic Adenoma of Buccal Mucosa: An Uncommon Presentation among Cheek Swellings
Authors: KM Sailesh
Published: February 2024

Cheek mass is a common presenting problem in Oral & Maxillofacial OPD. It may be due to many underlying causes like inflammation, cyst or neoplasm. Common cheek swellings sometimes come out as an uncommon lesion on histopathological examination where the provisional diagnosis is challenged. Therefore the final diagnosis of common small cheek swelling is not complete till its therapeutic removal and histopathological examination. We represent a case of young healthy female who reported with swelling of right side buccal mucosa which was finally diagnosed as pleomorphic adenoma based on histopathologic examination.
Enhancement of Facial Aesthetics and Function in Periodontally Compromised Adult Patients by an Interdisciplinary Approach: A Case Series
Authors: Agarwal SS
Published: February 2024

Periodontium is a common link between Orthodontics and Periodontics. Orthodontics is dependent on the inflammatory changes in periodontium for effective tooth movement. Orthodontic biomechanics and treatment planning are dependent on the health of periodontium and certain changes in the same are required while treating periodontally compromised adult patients. In this case series, we present successful management of two periodontally compromised adult patients by an interdisciplinary team approach.
Impact of School-University Partnerships and Professional Learning Communities
Authors: Adeoye Moses Adeleke , Akinnubi Olaolu Paul , Suleiman Yusuf , Mahmud Musa Aremu , Jimoh Hassanat Abdullateef
Published: February 2024

School-university partnerships and professional learning communities (PLCs) are important approaches to school reform that have the potential to improve teaching and learning and improve student outcomes. School-university partnerships are collaborative relationships between schools and universities that aim to improve teaching and learning outcomes by providing access to resources and expertise and by developing new curricula and instructional materials. This study analyzes the positive impact of partnerships and communities on teaching and learning outcomes but also acknowledges the challenges they face such as time constraints, funding, and cultural differences. The research method uses Systematic Literature Review (SLR). The data collection process is carried out by identifying and evaluating scientific articles that are relevant to the topic. A literature search was conducted through academic databases, such as PubMed, ERIC, and Google Scholar. The data found analyzed to identify patterns, trends, and consistencies in the findings. Drawing on existing literature and case studies of successful partnerships found that these collaborative models have the potential to significantly improve educational outcomes for students while providing meaningful professional development opportunities for teachers. Success factors include building relationships based on mutual respect and trust, ongoing communication and collaboration and structured professional development. It was concluded that implementing partnerships will create a culture for continuous improvement within the school community.
Audio-Assisted Smartbox Learning Media in IPAS Content of Metamorphosis of Animals for Fourth-Grade Students
Authors: Failasufah Meilia , Setyasto Novi
Published: February 2024

One of the prevalent issues faced by students in the IPAS subject is the utilization of monotonous media, resulting in lower learning outcomes. This research aims to develop and evaluate the feasibility and effectiveness of SmartBox media assisted by audio for the IPAS subject, specifically focusing on the topic of animal life cycles. Employing the Borg and Gall method, this study falls under the category of research and development with the research sample consisting of 27 students. The data collection techniques encompassed observation, interviews, tests, questionnaires, and document analysis. The evaluation results from expert validators in both content and media fields revealed scores of 98% and 92%, respectively, indicating a highly suitable categorization. Moreover, the media garnered positive responses from both students and teachers. Additionally, the developed media demonstrated its effectiveness in enhancing learning outcomes, as evidenced by a t-test result with a Sig. value of 0.000, indicating a significant difference between pretest and post-test data. This finding is supported by an n-gain score of 0.44, classified as moderate, signifying an increase in the average results of pretest and post-test using the audio-assisted SmartBox learning media. In conclusion, the SmartBox learning media with audio assistance for the IPAS subject on animal life cycles is deemed highly appropriate, effective, and valid for implementation in the teaching process, as it effectively improves student learning outcomes.
The Relationship between the Principal’s Leadership Behavior and the Intensity of Academic Supervision Implementation with Teacher Performance
Authors: Marhawati Besse , Masaong Abd. Kadim , Lestari Dian
Published: February 2024

This lack of teacher competence can impact teacher performance. The possible factors can affect teacher performance, namely, the leadership behaviors of the school principal and the intensity of the implementation of academic supervision. This study aims to analyze the relationship between principal leadership behaviors and the intensity of the implementation of academic supervision with teacher performance. This study uses a quantitative with a correlational design—data collection techniques using a questionnaire (questionnaire), observation, and documentation. Data analysis used a data validity test, reliability test, data normality test, data linear test, significance test, and hypothesis test by calculating the correlation coefficient. The results show (1) the principal's leadership behaviors has a positive and significant relationship with teacher performance, namely 50.2%, (2) the intensity of the implementation of academic supervision has a positive and significant relationship with teacher performance, namely 22.2%, (3) the principal's leadership behaviors and the intensity of the implementation of academic supervision has a positive and significant relationship with teacher performance, namely 71.07%.
Radar Tasikmalaya News Portal's Error Analysis in the Indonesian Language from a Linguistic Category Point of View
Authors: Nurjamilah Ai Siti , Nores K. Welly , Rosiana Shinta , Wijayanti Sri Hapsari , Solissa Everhard Markiano , Saputra Nanda
Published: February 2024

There are still many online news portals that make writing errors, not only in terms of spelling, but also in terms of morphology, syntax and semantics. The goal of this language mistake analysis is to analyze and repair phonological, morphological, syntactic, and semantic faults found on instructional pages of the Radar Tasikmalaya news site. The researcher employed a descriptive analytic method. The research methods employed in this study were observation, interviews, and literature studies, which involved reviewing all of the books, articles, notes, and reports that had anything to do with the issue being addressed. By performing numerous steps in the study process, including: (1) gathering data, (2) describing the data, (3) evaluating the data, and (4) drawing conclusions. The findings of a language mistake study for the Radar Tasikmalaya news portal's edition can be concluded that there are forms of language errors in the fields of phonology, morphology, syntax, and semantics. In linguistic-morphological category errors there are errors in affixation. Syntactic errors consist of errors in sentence construction. There are also semantic errors consisting of errors in the meaning of sentences that can make the reader misinterpret the sentence. Then there are errors in the use of spelling or phonology, these spelling errors consist of writing errors in the use of punctuation marks, especially in writing academic degrees, using standard words, writing foreign terms, and writing capital letters.
Comparative Perspectives: Exploring Workflow Efficiencies of BIM and CAD in 3D Modelling
Authors: Wardana Henricus Arya Wisnu , Maura Audrey , Suman Meliana Putri , Jacinda Steffania
Published: February 2024

Building Information Modelling (BIM) is a new technology to make genuine project contributions, especially in the industry, architecture, and construction sectors. However, in practice, many professional workforces choose computer-aided design (CAD) as the primary technology, which has formerly appeared and is further comprehensible. Building Information Modelling offered different perspectives on purpose to facilitate designers or architects to expertise in various fields. Building Information Modelling (BIM) contains informative data that can use some expertise as a solution to make the occupation more coherent. This research aims to comprehend the workflow differences between Computer Aided Design (CAD) and Building Information Modelling (BIM) system technology. We collated methods by reviewing some literature and reviewing case studies. Then, we compare the workflow and conclude which is more effective for architectural design. In this research, we explore the difference between BIM's workflow and Cad's workflow to know which is more effective. So, we conclude and can apply the technology appropriately in the workflow needed so that it can simplify the workflow.
Deep learning in modelling the protein–ligand interaction: new pathways in drug development
Authors: Barykin AD , Chepurnykh TV , Osipova ZM
Published: February 2024

The deep learning technologies have become the driver of the revolutionary changes in scientific research in various fields. The AlphaFold-2 neural network software development that has solved the semicentennial problem of 3D protein structure prediction based on primary amino acid sequence is the most obvious example of using such technologies in structural biology and biomedicine. The use of deep learning methods for the prediction of protein–ligand interactions can considerably simplify predicting, speed up the development of new effective pharmaceuticals and change the concept of drug design.
Pasteurella multocida effectively utilizes hyaluronic acid to facilitate its continuous growth - short comminication
Authors:   Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, Punjab, India, Raj Rajneesh , Kumar Sharma Ashwani , Kumar Arora Anil
Published: February 2024

Pasteurella multocida B: 2 (P. multocida) causes haemorrhagic septicemia (HS), a fatal disease in cattle and buffalo. Despite its widespread prevalence, little is known about the factors that contribute to P. multocida’s pathogenicity. This pathogen produces hyaluronidase, a hyaluronic acid degrading enzyme. However, its role in P. multocida pathogenicity is unknown. In this study we attempted to assess the potential of P. multocida in utilising hyaluronic acid as a nutrient in vitro. Six isolates of P. multocida, isolated from outbreaks of HS, were examined for their growth in a chemically defined medium (CDM) with glucose, and a CDM without glucose but with hyaluronic acid (HA) added. The bacterial growth was determined by counting the number of colonies at each observation time (24, 48, 72, 96 h), and was expressed as CFU millions/mL log10. P. multocida continued to grow throughout the period of the experiment in the CDM with HA. However, in the CDM with glucose, growth could be observed until 72 h, followed by a decline and then no growth after that. This is the first ever report of P. multocida utilising hyaluronic acid for its growth, a strategy that could be used to obtain nutrients for colonisation and proliferation.
Increasing long-chain n-3 fatty acids in beef from forage-finished cattle through supplementation with the calcium salts of fish oil
Authors:   Department of Animal Nutrition and Nutritional Diseases, School of Veterinary Medicine, Erciyes University, Kayseri, Turkey, Kucuk Osman , William Hess Bret , Paisley Steve , Underwood Keith , Clark Rule Daniel
Published: February 2024

Two experiments were conducted to determine the effects of dietary fish oil Ca salts supplementation on the muscle deposition of fatty acids, with the major focus on eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) in beef cattle. For Experiment 1, thirty-eight grazing LowLine Angus steers were divided into three groups and supplemented either control, fish oil (FO)- or palm oil (PO)-based fatty acid Ca salts, supplemented individually in dry form. In Experiment 2, 14 Angus heifers and 14 Angus steers were fed free-choice harvested forage and supplemented either PO or FO Ca salts, delivered as a suspension within dried molasses lick tubs. Growth performances, sensory characteristics and the concentrations of EPA and DHA of the M. Longissimus thoracis (LT) were evaluated. M. Longissimus thoracis fatty acid concentrations of EPA and DHA were greater (P<0.001) for cattle fed FO; whereas C18:2 n-6 and the ratio of n-6 to n-3 were greater (P<0.001) for cattle fed PO in both experiments. Sensory evaluation of LT steaks obtained from the carcasses of the LowLine steers of Experiment 1 did not reveal any adverse effects of the FO supplementation (P≥0.2695). We conclude that supplementing FO Ca-salts to forage-fed beef cattle increases muscle deposition of EPA and DHA, with no adverse effects on flavor. Supplementing fish oil to beef cattle is a way to meet the omega fatty acid requirements of humans.
Salmonella Typhimurium secondary infection induced macrophages apoptosis NO-dependent during Mycobacterium neoaurum infection
Authors:   College of Animal Medicine, Jilin Agricultural University, Changchun, China, Ren Jihong , Yu Dan , Sun Ying , Song Haichao , Jiang Xiuyun , Wang Chunfang
Published: February 2024

Mycobacterium neoaurum (M. neoaurum) and Salmonella Typhimurium (S. Typhimurium) are important zoonotic pathogens, and both are intracellular bacteria, which can induce cellular immunity. Coinfection is prevalent worldwide, even more prevalent than single infection. This study aimed to investigate the effect of M. neoaurum/S. Typhimurium coinfection on the percentage property of C57BL/6 mice regulatory T cells (Tregs) and the immune activity of RAW264.7 cells. The secretion of TNF-α, IFN-γ, IL-1β, IL-12 and iNOS in RAW264.7 cells was determined by ELISA. The expression of CD40+ , CD80+ and CD86+ costimulatory molecules on the surface of macrophages was analyzed by flow cytometry. A Nitric oxide (NO) assay was used to detect the production of NO in RAW264.7 cells. The apoptosis of RAW264.7 cells was detected by flow cytometry. The results showed that macrophage expressed a large number of cytokines and surface costimulatory molecules to enhance immune activity. S. Typhimurium secondary infection significantly increased the expression of iNOS and generation of NO, and M. neoaurum/S. Typhimurium-induced apoptosis was NO-dependent. Our data provide a theoretical basis for secondary infections by other pathogens after Nontuberculous Mycobacterium (NTM) infection, and lay a foundation for further research.
ВЫВОД ЭЛЕМЕНТАРНОГО ЗАРЯДА НА ОСНОВЕ ЕДИНОЙ ТЕОРИИ ВЗАИМОДЕЙСТВИЙ
Authors: Першуков Виктор , Першуков Вячеслав
Published: February 2024

В настоящее время предпринимаются попытки объединения микромира и макромира в единое целое материальное пространство, подчиненное единым законам. Основы единой теории взаимодействий (ЕТВ) представлены в статье и на ее основе выполнен вывод единицы элементарного заряда, что из существующей теории вывести не удается. На единой модели взаимодействия двух объектов, которая справедлива для объектов макромира и микромира, рассчитаны связи между электроном с массой покоя, элементарным зарядом, франклином, кулоном, массой объекта соответствующей одному электрон-вольту, постоянной Планка и постоянной тонкой структуры. Это позволяет уточнить численные значения фундаментальных констант существующей теории. В результате прояснен физический смысл элементарного заряда и его значение в микромире и макромире. Рассчитаны минимально возможный объект и максимально возможный объект (Вселенная) и их основные параметры, что позволяет создать полное представление о происходящих во вселенной процессах. ЕТВ позволяет с единой точки зрения изучить огромное пространство микромира, которое в существующей теории представляется в виде волн.
Áreas de gestión del Personal Operativo del Cuerpo de Bomberos de Ambato
Authors: TENEDA GARCÉS VÍCTOR ORLANDO , MURILLO GUERRERO BYRON RAMIRO , LEDESMA BÁRCENES FREDY VICENTE , SALTOS SALTOS NARCISA ELISABETH
Published: February 2024

La diversificación de los ámbitos de intervención del personal operativo del Cuerpo de Bomberos de Ambato (CBA), conlleva un complejo sistema de acciones a nivel operativo y administrativo, mismo que requiere de un alto nivel de dominio de los procesos, técnicas y protocolos de atención de emergencias, por lo que este trabajo investigativo ha buscado definir teóricamente las áreas de gestión que configuran la arquitectura multidisciplinaria de la carrera profesional bomberil. Esta investigación se enmarcó en el diseño documental, mediante la revisión de la legislación vigente, normativa institucional del CBA y artículos académicos de las diferentes bases de datos. La metodología empleada para la recogida y tratamiento de la información fue el análisis documental y de contenidos, así como los métodos lógicos. Entre los hallazgos obtenidos se resaltan la determinación del marco normativo que rige la labor bomberil, la identificación de los ámbitos de acción del CBA, la revisión de la articulación entre la estructura orgánica propuesta por el COESCOP y los niveles jerárquicos de la Pirámide de Mando Institucional. La consecución del objetivo general del trabajo fue la identificación y definición teórica de las cuatro áreas de gestión: Técnico-Operativa, Conducción y Mando Bomberil, Administrativa y Pedagógica. Finalmente se concluye que estas áreas y sub-áreas de gestión/conocimiento sirven de fundamento teórico para la determinación de las competencias técnicas y conductuales del personal operativo en cada nivel y grado.
ESTRATEGIA PARA EL FORTALECIMIENTO DEL PLAN DE ESTUDIOS ACADÉMICO DE LA “MADGSI”, ENFOCADO DESDE LA PERSPECTIVA DE LA CIBERSEGURIDAD Y LA CIBERDEFENSA
Authors: Ramírez Ruiz Giovanna Estefanía , Morales Carvajal Robinson Augusto , Lopez Cortes David Enrique , Castillo García Jaquelín , Parra Camacho Oscar Iván
Published: February 2024

El aumento del llamado “ciberespacio" para guardar información importante y confidencial han aumentado la posibilidad de ataques que buscan acceder a la información gubernamental y poner en riesgo sus operaciones. Por esta razón se creó la ferviente necesidad de implementar múltiples medidas de seguridad, como, por ejemplo, brindar capacitaciones a los funcionarios que les den conocimientos y herramientas para hacer frente a los riesgos que se enfrentan al usar los medios digitales.

Por eso, se propone la estrategia del fortalecimiento del plan de estudios académico de la maestría en Dirección y Gestión de la Seguridad Integral (MADGSI), enfocada desde la perspectiva de la ciberseguridad y la ciberdefensa al interior de la Escuela de Postgrados de la Fuerza Aérea Colombiana. Ello con el objetivo de facilitar los procesos de investigación y la continua mejora de la capacidad técnica y académica del personal involucrado en el marco del tema a tratar.
La economía de la defensa en Suramérica: breve análisis del gasto en defensa de Ecuador y Perú durante el periodo 2016-2019
Authors: Andrade-Vásquez Miguel
Published: February 2024

La economía es una de las disciplinas de las ciencias sociales más influyentes en el desarrollo de la defensa de los Estados. Las condicionantes que imponen los recursos limitados ante la crecientes necesidades en el ámbito de la seguridad frente a las múltiples amenazas demandan del análisis de la distribución de los presupuestos de defensa en la búsqueda de optimizar los recursos y alcanzar un aceptable nivel de seguridad para los Estados y su población. Para naciones como Ecuador y Perú, países en vías de desarrollo, la economía de la defensa juega un rol esencial dentro de los limitados presupuestos frente a las crecientes demandas sociales al interior de las fronteras nacionales. Sin embargo, a pesar de las sus similares características, ambos Estados reflejan distantes posiciones dentro de las clasificaciones de fortalezas militares. El artículo tiene por objetivo realizar un análisis comparado entre ambos Estados respecto al gasto en defensa con la finalidad de comprender la diferencia en cuanto a la clasificación respecto a fortalezas militares existente entre Ecuador y Perú desde una perspectiva de la economía de la defensa. El análisis concluye que, los diferentes roles adicionales que hoy en día cumplen las Fuerzas Armadas de estos Estados, además de los tradicionales, determinan la construcción de sus capacidades y la consiguiente necesidad de modernización de equipamiento militar, lo cual se configura como la principal motivación para la diferencia entre ambos Estados respecto al ranking de fortalezas militares 2020.
Cadena de los Lácteos del Cantón Alausí, Provincia de Chimborazo: Principales Características y Relaciones entre sus Agentes
Authors: MARTINEZ BENITEZ CLEOPATRA , ZAMBRANO VERA DANNY , BERMEO OÑATE LIZBETH
Published: February 2024

La industria de los lácteos, en Ecuador, ha mostrado ser uno de los sectores más dinámico e importante en los últimos años. La región Andina se caracteriza por una alta concentración de hatos ganaderos y la producción de leche cruda, razones que motivaron a realizar el presente estudio, cuyo objetivo central es la caracterización de la estructura y el funcionamiento de la cadena de los lácteos, aplicada al cantón Alausí, provincia de Chimborazo, al considerarse una zona representativa en la producción nacional. La investigación está soportada en la revisión de literatura, identificándose una serie de aportes teóricos referentes a las cadenas de producción con enfoque agroalimentario; así mismo, el estudio metodológico incorpora un trabajo empírico, de tipo mixto, aplicándose dos tipos de encuestas, la primera de uso para los productores de leche y la segunda para las industrias lácteas, paralelamente la aplicación de la observación directa y el empleo de entrevistas no estructuradas a otros agentes participes en esta actividad, logrando así una descripción integral de la cadena.
The optimizing method of centralized multi-agent systems organizational structure in automatic mode
Authors: Dubenko Yuri Vladimirovich , Dyshkant Evgeniy Evgen'evich , Obozovskiy Aleksandr Anatol'evich
Published: February 2024

The organizational structure of a multi-agent system (MAS) is a set of roles and relationships of agents, com-ponents that control their behavior, as well as rules governing the interaction of system elements. The effectiveness of the MAS largely depends on the characteristics of the organizational structure used. Existing solutions in this area have a significant disadvantage, namely low adaptability to changes in environmental parameters or adjustment of the conditions of the task, which consists in the need to restart the procedure for synthesizing the organizational structure of the MAS. The problem of automatic optimization of the organizational structure of centralized MAS in the conditions of changed environmental parameters or the task is of particular relevance for centralized MAS with a strict hierarchical structure, whose agents can be divided into two classes – agents-managers, agents-subordinates. The subject of the study is the methods of synthesis of the organizational structure of the MAS. The aim of the work is to develop a method for optimizing the organizational structure of centralized MAS in automatic mode. To achieve this goal, the concepts of primary and secondary agent resources were introduced, based on a biogeographic algorithm, a method was developed that regulates the movement of subordinate agents between groups depending on the degree of attractiveness of the agent manager (depends on the sum of estimates of the effectiveness of subordinate agents managed by him, as well as on the distance from this subordinate agent). The developed method can find its practical application in the implementation of the following tasks: inspection or patrolling (protection) of infrastructure facilities by mobile robots, the implementation of artificial intelligence in computer games.
HoReCa Waste Management – A Case Study
Authors:   Babes-Bolyai University, Dinu Loredana , Dinu Gabriel ,   Babes-Bolyai University
Published: February 2024

In an era of growing environmental awareness, the HoReCa industry faces significant challenges in waste management. This paper explores the complexity of this issue and analyses the solutions proposed by experts to transform this industry into an agent of sustainability. Issues such as abundant food waste, single-use packaging, and inadequate recycling are discussed, highlighting the increased pressure on resources in the digital age. Despite these challenges, opportunities for innovation in practices, packaging, and community collaborations are emphasized.
A Survey of LQE and MPC Discrete-Control for Acrobot
Authors:   Ho Chi Minh city University of Technology and Education, Le Thanh-Tri-Dai , Doan Le-Thien-Bao ,   Ho Chi Minh city University of Technology and Education, Vo Hoang-Anh-Thai ,   Ho Chi Minh city University of Technology and Education, Trinh Hoang-Loi ,   Ho Chi Minh city University of Technology and Education, Nguyen Tan-Dung ,   Ho Chi Minh city University of Technology and Education, Tran Quoc-Khanh ,   Ho Chi Minh city University of Technology and Education, Tran Hoai-Vong ,   Ho Chi Minh city University of Technology and Education, Nguyen Xuan-Vinh ,   Ho Chi Minh city University of Technology and Education
Published: February 2024

This paper surveys the Linear Quadratic Estimation (LQE) and Model Predictive Control (MPC) discrete control methods applied to the Acrobot system. Both techniques aim to achieve and maintain a balanced position for the Acrobot. Through evaluation and comparison, we highlight their strengths, limitations, and potential applications, offering insights for future robotic control research.