bluuebunny/crossref_metadata_2025 huggingface dataset:
Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction
Authors: Davidson Terry L. , Stevenson Richard J.
Published: February 2024

The hippocampus is a critical brain substrate for learning and memory; events that harm the hippocampus can seriously impair mental and behavioral functioning. Hippocampal pathophysiologies have been identified as potential causes and effects of a remarkably diverse array of medical diseases, psychological disorders, and environmental sources of damage. It may be that the hippocampus is more vulnerable than other brain areas to insults that are related to these conditions. One purpose of this review is to assess the vulnerability of the hippocampus to the most prevalent types of insults in multiple biomedical domains (i.e., neuroactive pathogens, neurotoxins, neurological conditions, trauma, aging, neurodegenerative disease, acquired brain injury, mental health conditions, endocrine disorders, developmental disabilities, nutrition) and to evaluate whether these insults affect the hippocampus first and more prominently compared to other brain loci. A second purpose is to consider the role of hippocampal blood–brain barrier (BBB) breakdown in either causing or worsening the harmful effects of each insult. Recent research suggests that the hippocampal BBB is more fragile compared to other brain areas and may also be more prone to the disruption of the transport mechanisms that act to maintain the internal milieu. Moreover, a compromised BBB could be a factor that is common to many different types of insults. Our analysis indicates that the hippocampus is more vulnerable to insults compared to other parts of the brain, and that developing interventions that protect the hippocampal BBB may help to prevent or ameliorate the harmful effects of many insults on memory and cognition.
Could Adverse Effects of Antibiotics Due to Their Use/Misuse Be Linked to Some Mechanisms Related to Nonalcoholic Fatty Liver Disease?
Authors: Tarantino Giovanni , Citro Vincenzo
Published: February 2024

Nonalcoholic fatty liver disease, recently re-named metabolic dysfunction-associated steatotic fatty liver disease, is considered the most prevalent liver disease worldwide. Its molecular initiation events are multiple and not always well-defined, comprising insulin resistance, chronic low-grade inflammation, gut dysbiosis, and mitochondrial dysfunction, all of them acting on genetic and epigenetic grounds. Nowadays, there is a growing public health threat, which is antibiotic excessive use and misuse. This widespread use of antibiotics not only in humans, but also in animals has led to the presence of residues in derived foods, such as milk and dairy products. Furthermore, antibiotics have been used for many decades to control certain bacterial diseases in high-value fruit and vegetables. Recently, it has been emphasised that antibiotic-induced changes in microbial composition reduce microbial diversity and alter the functional attributes of the microbiota. These antibiotic residues impact human gut flora, setting in motion a chain of events that leads straight to various metabolic alterations that can ultimately contribute to the onset and progression of NAFLD.
A Novel Non-Intrusive Load Monitoring Algorithm for Unsupervised Disaggregation of Household Appliances
Authors: Criado-Ramón D. , Ruiz L. G. B. , Iruela J. R. S. , Pegalajar M. C.
Published: February 2024

This paper introduces the first completely unsupervised methodology for non-intrusive load monitoring that does not rely on any additional data, making it suitable for real-life applications. The methodology includes an algorithm to efficiently decompose the aggregated energy load from households in events and algorithms based on expert knowledge to assign each of these events to four types of appliances: fridge, dishwasher, microwave, and washer/dryer. The methodology was developed to work with smart meters that have a granularity of 1 min and was evaluated using the Reference Energy Disaggregation Dataset. The results show that the algorithm can disaggregate the refrigerator with high accuracy and the usefulness of the proposed methodology to extract relevant features from other appliances, such as the power use and duration from the heating cycles of a dishwasher.
Exploring Students’ Hands-On Performance, Attitudes, and Usability with Arduino Modular Boards
Authors: Tselegkaridis Sokratis , Sapounidis Theodosios
Published: February 2024

Utilizing Arduino development boards for learning microcontroller circuits is a prevalent practice across various educational levels. Nevertheless, the literature offers limited insights into the impact of these boards on student performance and attitudes. Therefore, this paper aims to investigate the performance of 58 university students in learning microcontroller circuits with modular boards designed for Arduino through a series of 4 exercises. Specifically, students’ performance is assessed through pre-tests and post-tests, in three learning units: (a) microcontroller, (b) coding, and (c) circuit. Additionally, the study captures students’ attitudes and measures their perceived usability of modular boards. For this purpose, the students completed a specially designed attitude questionnaire and the system usability scale (SUS) questionnaire. Statistical analysis is conducted using t-tests, ANOVA, and ANCOVA, along with bootstrapping. The findings reveal statistically significant differences between pre-tests and post-tests in all cases. Among the three learning units, the use of modular boards appears to have the most significant impact on coding. Based on students’ responses, the SUS results indicate that modular boards appear to be a quite usable approach for teaching microcontrollers. Finally, students generally express positive attitudes toward modular boards.
AI Model for Industry Classification Based on Website Data
Authors: Jagrič Timotej , Herman Aljaž
Published: February 2024

This paper presents a broad study on the application of the BERT (Bidirectional Encoder Representations from Transformers) model for multiclass text classification, specifically focusing on categorizing business descriptions into 1 of 13 distinct industry categories. The study involved a detailed fine-tuning phase resulting in a consistent decrease in training loss, indicative of the model’s learning efficacy. Subsequent validation on a separate dataset revealed the model’s robust performance, with classification accuracies ranging from 83.5% to 92.6% across different industry classes. Our model showed a high overall accuracy of 88.23%, coupled with a robust F1 score of 0.88. These results highlight the model’s ability to capture and utilize the nuanced features of text data pertinent to various industries. The model has the capability to harness real-time web data, thereby enabling the utilization of the latest and most up-to-date information affecting to the company’s product portfolio. Based on the model’s performance and its characteristics, we believe that the process of relative valuation can be drastically improved.
Emerging Applications and Translational Challenges for AI in Healthcare
Authors: Liu Sidong , Castillo-Olea Cristián , Berkovsky Shlomo
Published: February 2024

The past decade has witnessed an explosive growth in the development and use of artificial intelligence (AI) across diverse fields [...]
Leveraging Semantic Text Analysis to Improve the Performance of Transformer-Based Relation Extraction
Authors: Evans Marie-Therese Charlotte , Latifi Majid , Ahsan Mominul , Haider Julfikar
Published: February 2024

Keyword extraction from Knowledge Bases underpins the definition of relevancy in Digital Library search systems. However, it is the pertinent task of Joint Relation Extraction, which populates the Knowledge Bases from which results are retrieved. Recent work focuses on fine-tuned, Pre-trained Transformers. Yet, F1 scores for scientific literature achieve just 53.2, versus 69 in the general domain. The research demonstrates the failure of existing work to evidence the rationale for optimisations to finetuned classifiers. In contrast, emerging research subjectively adopts the common belief that Natural Language Processing techniques fail to derive context and shared knowledge. In fact, global context and shared knowledge account for just 10.4% and 11.2% of total relation misclassifications, respectively. In this work, the novel employment of semantic text analysis presents objective challenges for the Transformer-based classification of Joint Relation Extraction. This is the first known work to quantify that pipelined error propagation accounts for 45.3% of total relation misclassifications, the most poignant challenge in this domain. More specifically, Part-of-Speech tagging highlights the misclassification of complex noun phrases, accounting for 25.47% of relation misclassifications. Furthermore, this study identifies two limitations in the purported bidirectionality of the Bidirectional Encoder Representations from Transformers (BERT) Pre-trained Language Model. Firstly, there is a notable imbalance in the misclassification of right-to-left relations, which occurs at a rate double that of left-to-right relations. Additionally, a failure to recognise local context through determiners and prepositions contributes to 16.04% of misclassifications. Furthermore, it is highlighted that the annotation scheme of the singular dataset utilised in existing research, Scientific Entities, Relations and Coreferences (SciERC), is marred by ambiguity. Notably, two asymmetric relations within this dataset achieve recall rates of only 10% and 29%.
Pseudolycoriella hygida (Sauaia and Alves)—An Overview of a Model Organism in Genetics, with New Aspects in Morphology and Systematics
Authors: Menzel Frank , Kramp Katja , Amorim Dalton de Souza , Gorab Eduardo , Uliana João Vitor Cardoso , Sauaia Heni , Monesi Nadia
Published: February 2024

Pseudolycoriella hygida (Sauaia & Alves, 1968) is a sciarid that has been continuously cultured in the laboratory for nearly 60 years. Studies on this species have contributed to the understanding of DNA puffs, which are characteristic of Sciaridae, and to the knowledge of more general aspects of insect biology, including cell death, nucleolar organization, and the role of the hormone ecdysone during molting. The genome of Psl. hygida has now been sequenced, and it is the third publicly available sciarid genome. The aim of this work is to expand the current knowledge on Psl. hygida. The morphology of the adults is revisited. The morphology of larvae and pupae is described, together with the behavior of immature stages under laboratory conditions. Cytogenetic maps of the salivary gland polytene chromosomes are presented, together with a comparative analysis of the mitotic chromosomes of six different sciarid species. Pseudolycoriella hygida was originally described as a species of Bradysia and recently moved to Pseudolycoriella. We examine here the systematic position of Psl. hygida in the latter genus. Our results extend the characterization of an unconventional model organism and constitute an important resource for those working on the cytogenetics, ecology, taxonomy, and phylogenetic systematics of sciarids.
Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components
Authors: Mannozzi Joseph , Massoud Louis , Stavres Jon , Al-Hassan Mohamed-Hussein , O’Leary Donal S.
Published: February 2024

Metabolic syndrome (MetS) describes a set of disorders that collectively influence cardiovascular health, and includes hypertension, obesity, insulin resistance, diabetes, and dyslipidemia. All these components (hypertension, obesity, dyslipidemia, and prediabetes/diabetes) have been shown to modify autonomic function. The major autonomic dysfunction that has been documented with each of these components is in the control of sympathetic outflow to the heart and periphery at rest and during exercise through modulation of the arterial baroreflex and the muscle metaboreflex. Many studies have described MetS components in singularity or in combination with the other major components of metabolic syndrome. However, many studies lack the capability to study all the factors of metabolic syndrome in one model or have not focused on studying the effects of how each component as it arises influences overall autonomic function. The goal of this review is to describe the current understanding of major aspects of metabolic syndrome that most likely contribute to the consequent/associated autonomic alterations during exercise and discuss their effects, as well as bring light to alternative mechanisms of study.
Tele-Monitoring Applications in Respiratory Allergy
Authors: Aggelidis Xenofon , Kritikou Maria , Makris Michael , Miligkos Michael , Papapostolou Niki , Papadopoulos Nikolaos G. , Xepapadaki Paraskevi
Published: February 2024

Respiratory allergic diseases affect over 500 million people globally and pose a substantial burden in terms of morbidity, mortality, and healthcare costs. Restrictive factors such as geographical disparities, infectious pandemics, limitations in resources, and shortages of allergy specialists in underserved areas impede effective management. Telemedicine encompasses real-time visits, store-and-forward option triage, and computer-based technologies for establishing efficient doctor-patient communication. Recent advances in digital technology, including designated applications, informative materials, digital examination devices, wearables, digital inhalers, and integrated platforms, facilitate personalized and evidence-based care delivery. The integration of telemonitoring in respiratory allergy care has shown beneficial effects on disease control, adherence, and quality of life. While the COVID-19 pandemic accelerated the adoption of telemedicine, certain concerns regarding technical requirements, platform quality, safety, reimbursement, and regulatory considerations remain unresolved. The integration of artificial intelligence (AI) in telemonitoring applications holds promise for data analysis, pattern recognition, and personalized treatment plans. Striking the balance between AI-enabled insights and human expertise is crucial for optimizing the benefits of telemonitoring. While telemonitoring exhibits potential for enhancing patient care and healthcare delivery, critical considerations have to be addressed in order to ensure the successful integration of telemonitoring into the healthcare landscape.
Artificial Intelligence Language Model Performance for Rapid Intraoperative Queries in Plastic Surgery: ChatGPT and the Deep Inferior Epigastric Perforator Flap
Authors: Atkinson Connor J. , Seth Ishith , Xie Yi , Ross Richard J. , Hunter-Smith David J. , Rozen Warren M. , Cuomo Roberto
Published: February 2024

Background: The integration of artificial intelligence in healthcare has led to the development of large language models that can address various medical queries, including intraoperatively. This study investigates the potential of ChatGPT in addressing intraoperative questions during the deep inferior epigastric perforator flap procedure. Methods: A series of six intraoperative questions specific to the DIEP flap procedure, derived from real-world clinical scenarios, were proposed to ChatGPT. A panel of four experienced board-certified plastic surgeons evaluated ChatGPT’s performance in providing accurate, relevant, and comprehensible responses. Results: The Likert scale demonstrated to be medically accurate, systematic in presentation, and logical when providing alternative solutions. The mean readability score of the Flesch Reading Ease Score was 28.7 (±0.8), the Flesch–Kincaid Grade Level was 12.4 (±0.5), and the Coleman–Liau Index was 14.5 (±0.5). Suitability-wise, the DISCERN score of ChatGPT was 48 (±2.5) indicating suitable and comprehensible language for experts. Conclusions: Generative AI tools such as ChatGPT can serve as a supplementary tool for surgeons to offer valuable insights and foster intraoperative problem-solving abilities. However, it lacks consideration of individual patient factors and surgical nuances. Nevertheless, further refinement of its training data and rigorous scrutiny under experts to ensure the accuracy and up-to-date nature of the information holds the potential for it to be utilized in the surgical field.
Optimal Plate Choice for High-Neck Mandibular Condyle Fracture: A Mechanistic Analysis of 16 Options
Authors: Okulski Jakub , Kozakiewicz Marcin , Krasowski Michał , Zieliński Rafał , Szymor Piotr
Published: February 2024

(1) Background: Mandibular fractures are common, with the condylar process being a frequent site of injury, accounting for 25–45% of cases. This research aims to assess the mechanical suitability of various plates for high-neck condyle fractures. (2) Methods: Polyurethane models mimicking high-neck condyle fractures were utilized in this study. Sixteen distinct plate designs, constructed from titanium sheets, were tested. The figures underwent force assessments on a durability testing apparatus, and the relationship between used force and fracture movement was documented. (3) Results: For high-neck breaking, the two straight plates emerged as the most effective, aligning with established osteosynthesis standards. The second-best plate exhibited nearly half the strength of the gold standard. (4) Conclusions: In response to the aim of this study, considering the mechanical aspects, the double plain plate stands out as the optimal choice for osteosynthesis in cases of high-neck fractures of the mandibular condylar process. In addition, the authors propose the Mechanical Excellence Factor (MEF) as a superior metric for appraising a plate’s mechanical force, surpassing the conventional Plate Design Factor (PDF).
Is the Elite Female Athlete’s Pelvic Floor Stronger?
Authors: Acevedo-Gómez María Barbaño , Rodríguez-López Elena Sonsoles , Oliva-Pascual-Vaca Ángel , Fernández-Rodríguez Tomás , Basas-García Ángel , Ojedo-Martín Cristina
Published: February 2024

Background: Exercise can stress the pelvic floor muscles (PFMs). This study sought to assess the strength of the PFMs according to the level of physical exercise. Methods: An analytical observational study was carried out using digital palpation and dynamometry measurements to assess PF strength. Healthy nulliparous women were stratified according to physical exercise (physically active and sedentary) and level of physical exercise (elite, amateur, and sedentary). Results: Fifty-four women were analyzed, with a mean age of 25.64 (5.33) years and a BMI of 21.41 (2.96) kg/m2. Differences in the passive force and strength were observed between both groups of women (p < 0.05), and the strength was around two times higher in physically active women (p < 0.05). The strength was similar between elite female athletes and sedentary women (p > 0.05), but statistical differences were found with amateurs (p < 0.05). The PFM strength (p = 0.019) of elite female athletes (0.34 N) was almost half that of amateurs (0.63 N) and twice as strong as that of sedentary women (0.20 N). However, these differences were not significant using digital palpation (p = 0.398). Conclusions: Women who exercise generally have greater PFM strength than women who do not exercise. Physical exercise could strengthen the PFM; however, the high intensity demanded by high-level sports does not seem to proportionally increase the strength of the PFMs.
Gender Difference in REM Sleep Behavior Disorder in Japanese Population: Polysomnography and Sleep Questionnaire Study
Authors: Mano Mamiko , Nomura Atsuhiko , Sasanabe Ryujiro
Published: February 2024

Rapid eye movement (REM) sleep behavior disorder (RBD) is generally common among males and is an established risk factor for neurodegenerative diseases. As the population ages, the prevalence of α-synucleinopathy (such as Parkinson’s disease) is increasing. Additionally, the number of female patients is increasing in Japan. Therefore, we aimed to clarify the clinical characteristics of RBD from the perspective of gender differences in the Japanese population. The proportion of male RBD patients (65.2%) was significantly higher than that of female patients (34.8%). Additionally, female patients (70.5 ± 8.2 years) were significantly older than male patients (67.9 ± 8.0 years, p < 0.05). The mean score on the RBD Screening Questionnaire was significantly higher in male patients than in female (8.6 ± 2.9 vs. 7.7 ± 3.1, p < 0.05), while the mean score on the Pittsburgh Sleep Quality Index was significantly higher in males (5.9 ± 3.8 vs. 7.2 ± 3.600, p < 0.001). The Self-rating Depression Scale in females was 41.7 ± 8.5, and they were more likely to show depressive tendencies than males. In polysomnography, higher rates of obstructive sleep apnea and longer duration of stage N1 sleep were detected in males. After adjusting for age, BMI, and polysomnographic parameters, we found that female RBD patients had significantly worse sleep quality and rates of depression compared to male patients.
Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated Cirrhosis: Randomized, Placebo-Controlled Study
Authors: Efremova Irina , Maslennikov Roman , Zharkova Maria , Poluektova Elena , Benuni Nona , Kotusov Aleksandr , Demina Tatyana , Ivleva Aleksandra , Adzhieva Farida , Krylova Taisiya , Ivashkin Vladimir
Published: February 2024

(1) Background: The aim was to evaluate the effectiveness of the probiotic containing Saccharomyces boulardii in the treatment of small intestinal bacterial overgrowth (SIBO) in patients with decompensated cirrhosis. (2) Methods: This was a blinded, randomized, placebo-controlled study. (3) Results: After 3 months of treatment, SIBO was absent in 80.0% of patients in the probiotic group and in 23.1% of patients in the placebo group (p = 0.002). The patients with eliminated SIBO had decreased frequency of ascites and hepatic encephalopathy, the increased platelets and albumin levels, the decreased blood levels of total bilirubin, biomarkers of bacterial translocation (lipopolysaccharide [LPS]) and systemic inflammation (C-reactive protein), and positive changes in markers of hyperdynamic circulation compared with the state at inclusion. There were no significant changes in the claudin 3 level (the intestinal barrier biomarker) in these patients. No significant changes were observed in the group of patients with persistent SIBO. The serum level of nitrate (endothelial dysfunction biomarker) was lower in patients with eradicated SIBO than in patients with persistent SIBO. One (5.3%) patient with eradicated SIBO and six (42.9%) patients with persistent SIBO died within the first year of follow-up (p = 0.007). (4) Conclusions: SIBO eradication was an independent predictor of a favorable prognosis during the first year of follow-up.
Occlusal Caries Detection with Intraoral Scanners in Pediatric Dentistry: A Comparative Clinical Study
Authors: Schulz-Weidner Nelly , Gruber Marina , Wöstmann Bernd , Uebereck Constanze Friederike , Krämer Norbert , Schlenz Maximiliane Amelie
Published: February 2024

Background: The aim of this clinical study was to compare the occlusal caries detection (OCD) performance of the intraoral scanners (IOSs) Trios 4 (TIO, 3Shape) and Emerald S (EME, Planmeca) and the Diagnocam (DIA, KaVo) with the established visual (WHO) examination (VIS, reference method). Methods: Between 08/2022 and 02/2023, 60 children (mean age 9.6 ± 2.5 years) were examined as part of their regular dental checkups. OCD was performed at the tooth level, separately for primary and permanent unrestored teeth. Furthermore, two thresholds were analyzed: sound versus overall caries (pooled data of enamel and dentin caries, TH1) and pooled data of sound and enamel caries versus dentin caries (TH2). Results: The best agreement with the reference method (reliability) in both dentitions was obtained for DIA (ĸ = 0.829/ĸ = 0.846; primary/permanent teeth), followed by EME (ĸ = 0.827/ĸ = 0.837) and TIO (ĸ = 0.714/ĸ = 0.680). Similar results were shown for the diagnostic quality (sensitivity, specificity and area under the curve of the receiver operating characteristic curve), with higher values for TH1 than for TH2. Both IOSs and the DIA showed worse results than the reference method VIS. Conclusions: Currently, IOS should be used as an additional caries detection tool, especially for visualization, and cannot be recommended as a basic tool for diagnosis or invasive/noninvasive therapy decisions in OCD.
Androgen Insensitivity Syndrome with Bilateral Gonadal Sertoli Cell Lesions, Sertoli–Leydig Cell Tumor, and Paratesticular Leiomyoma: A Case Report and First Systematic Literature Review
Authors: Karseladze Apollon I. , Asaturova Aleksandra V. , Kiseleva Irina A. , Badlaeva Alina S. , Tregubova Anna V. , Zaretsky Andrew R. , Uvarova Elena V. , Zanelli Magda , Palicelli Andrea
Published: February 2024

Androgen insensitivity syndrome (AIS) is a rare Mendelian disorder caused by mutations of the androgen receptor (AR) gene on the long arm of the X chromosome. As a result of the mutation, the receptor becomes resistant to androgens, and hence, karyotypically male patients (46,XY) carry a female phenotype. Their cryptorchid gonads are prone to the development of several types of tumors (germ cell, sex cord stromal, and others). Here, we report a 15-year-old female-looking patient with primary amenorrhea who underwent laparoscopic gonadectomy. Histologically, the patient’s gonads showed Sertoli cell hamartomas (SCHs) and adenomas (SCAs) with areas of Sertoli–Leydig cell tumors (SLCTs) and a left-sided paratesticular leiomyoma. Rudimentary Fallopian tubes were also present. The patient’s karyotype was 46,XY without any evidence of aberrations. Molecular genetic analysis of the left gonad revealed two likely germline mutations—a pathogenic frameshift deletion in the AR gene (c.77delT) and a likely pathogenic missense variant in the RAC1 gene (p.A94V). Strikingly, no somatic mutations, fusions, or copy number variations were found. We also performed the first systematic literature review (PRISMA guidelines; screened databases: PubMed, Scopus, Web of Science; ended on 7 December 2023) of the reported cases of patients with AIS showing benign or malignant Sertoli cell lesions/tumors in their gonads (n = 225; age: 4–84, mean 32 years), including Sertoli cell hyperplasia (1%), Sertoli cell nodules (6%), SCHs (31%), SCAs (36%), Sertoli cell tumors (SCTs) (16%), and SLCTs (4%). The few cases (n = 14, 6%; six SCAs, four SCTs, two SLCTs, and two SCHs) with available follow-up (2–49, mean 17 months) showed no evidence of disease (13/14, 93%) or died of other causes (1/14, 7%) despite the histological diagnosis. Smooth muscle lesions/proliferations were identified in 19 (8%) cases (including clearly reported rudimentary uterine remnants, 3 cases; leiomyomas, 4 cases). Rudimentary Fallopian tube(s) were described in nine (4%) cases. Conclusion: AIS may be associated with sex cord/stromal tumors and, rarely, mesenchymal tumors such as leiomyomas. True malignant sex cord tumors can arise in these patients. Larger series with longer follow-ups are needed to estimate the exact prognostic relevance of tumor histology in AIS.
Association between Preoperative Glucose Dysregulation and Delirium after Non-Cardiac Surgery
Authors: Oh Ah Ran , Lee Dong Yun , Lee Seunghwa , Lee Jong-Hwan , Yang Kwangmo , Choi Byungjin , Park Jungchan
Published: February 2024

This study aimed to investigate the association between glucose dysregulation and delirium after non-cardiac surgery. Among a total of 203,787 patients who underwent non-cardiac surgery between January 2011 and June 2019 at our institution, we selected 61,805 with available preoperative blood glucose levels within 24 h before surgery. Patients experiencing glucose dysregulation were divided into three groups: hyperglycemia, hypoglycemia, and both. We compared the incidence of postoperative delirium within 30 days after surgery between exposed and unexposed patients according to the type of glucose dysregulation. The overall incidence of hyperglycemia, hypoglycemia, and both was 5851 (9.5%), 1452 (2.3%), and 145 (0.2%), respectively. The rate of delirium per 100 person-months of the exposed group was higher than that of the unexposed group in all types of glucose dysregulation. After adjustment, the hazard ratios of glucose dysregulation in the development of delirium were 1.35 (95% CI, 1.18–1.56) in hyperglycemia, 1.36 (95% CI, 1.06–1.75) in hypoglycemia, and 3.14 (95% CI, 1.27–7.77) in both. The subgroup analysis showed that exposure to hypoglycemia or both to hypo- and hyperglycemia was not associated with delirium in diabetic patients, but hyperglycemia was consistently associated with postoperative delirium regardless of the presence of diabetes. Preoperative glucose dysregulation was associated with increased risk of delirium after non-cardiac surgery. Our findings may be helpful for preventing postoperative delirium, and further investigations are required to verify the association and mechanisms for the effect we observed.
Contrast-Enhanced Mammography-Guided Biopsy: Preliminary Results of a Single-Center Retrospective Experience
Authors: Sammarra Matteo , Piccolo Claudia Lucia , Sarli Marina , Stefanucci Rita , Tommasiello Manuela , Orsaria Paolo , Altomare Vittorio , Beomonte Zobel Bruno
Published: February 2024

Background: CEM-guided breast biopsy is an advanced diagnostic procedure that takes advantage of the ability of CEM to enhance suspicious breast lesions. The aim pf this paper is to describe a single-center retrospective experience on CEM-guided breast biopsy in terms of procedural features and histological outcomes. Methods: 69 patients underwent the procedure. Patient age, breast density, presentation, dimensions, and lesion target enhancement were recorded. All the biopsy procedures were performed using a 7- or 10-gauge (G) vacuum-assisted biopsy needle. The procedural approach (horizontal or vertical) and the decubitus of the patient (lateral or in a sitting position) were noted. Results: A total of 69 patients underwent a CEM-guided biopsy. Suspicious lesions presented as mass enhancement in 35% of cases and non-mass enhancement in 65% of cases. The median size of the target lesions was 20 mm. The median procedural time for each biopsy was 10 ± 4 min. The patients were placed in a lateral decubitus position in 52% of cases and seated in 48% of cases. The most common approach was horizontal (57%). The mean AGD was 14.8 mGy. At histology, cancer detection rate was 28% (20/71). Conclusions: CEM-guided biopsy was feasible, with high procedure success rates and high tolerance by the patients.
Subjective Complaints and Coping Strategies of Individuals with Reported Low-Frequency Noise Perceptions
Authors: Erdelyi Kristina H. , Fuermaier Anselm B. M. , Tucha Lara , Tucha Oliver , Koerts Janneke
Published: February 2024

Background: Subjective everyday hindrances associated with low-frequency noise (LFN) can be high; however, there is still a lot unknown about experienced complaints. This study aims to investigate (1) subjective complaints and (2) coping strategies of individuals reporting everyday hindrances from LFN. Methods: Cognition, depressive symptoms, sleeping, fatigue, stress, and coping questionnaires were administered to participants sampled for their LFN complaints (LFN1 = 181), LFN complainants derived from a community sample (LFN2 = 239), and a comparison group without LFN complaints (CG = 410). Results: Individuals reporting LFN perceptions reported complaints in all domains and showed a higher proportion of above average symptom severity compared to the CG. Most complaints were reported by the LFN1 group, the least by the CG. However, on some sleeping, fatigue, and stress-related variables, a similar or even higher symptom severity was observed in the LFN2 group. Further, all groups used a similar combination of multiple coping strategies, although the LFN1 group scored higher on support seeking. Conclusions: There might be differences in the complaint severity between different LFN subgroups and future investigations of primary and secondary complaints are necessary. Also, more research about the use and success of coping strategies for LFN-related hindrances are needed for clear conclusions.
Deep Container Fabrication by Forging with High- and Low-Density Wood
Authors: Uejima Hinako , Kuboki Takashi , Tanaka Soichi , Kajikawa Shohei
Published: February 2024

This paper presents a method for applying forging to high-density wood. A cylindrical container was formed using a closed die, and the appropriate conditions for temperature and punch length were evaluated. Ulin, which is a high-density wood, and Japanese cedar, which is a low-density wood and widely used in Japan, were used as test materials. The pressing directions were longitudinal and radial based on wood fiber orientation, and the shape and density of the resulting containers were evaluated. In the case of ulin, cracks decreased by increasing the temperature, while temperature had little effect on Japanese cedar. Containers without cracks were successfully formed by using a punch of appropriate length. The density of the containers was uniform in the punch length l = 20 and 40 mm in the L-directional pressing and l = 20 mm in the R-directional pressing when using ulin, with an average density of 1.34 g/cm3. This result indicates the forging ability of ulin is high compared to that of commonly used low-density woods. In summary, this paper investigated the appropriate parameters for forging with ulin. As a result, products of more uniform density than products made by cutting were obtained.
A Novel Method for Secondary Mandible Reconstruction to Re-Achieve a Native Condyle Position Comprising a New Design for Cutting Guides and New Positioning Devices
Authors: Lentge Fritjof , Jehn Philipp , Neuhaus Michael-Tobias , Bettag Stephan A. , Gellrich Nils-Claudius , Korn Philippe
Published: February 2024

Secondary mandibular reconstruction using fibular free flaps (FFF) is a technical challenge for surgeons. Appropriate operation planning is crucial for postoperative quality control and is notably necessary for the (re-) achievement of a physiological condylar position, and the sensible expansion and shaping of the transplant. Computer-assisted planning may help to reconstruct mandibular defects in a patient-specific and precise manner. Herein, we present a newly-developed workflow for secondary mandibular reconstruction using FFF; it comprises digital planning and in-house manufacturing to perform precise secondary mandible reconstruction. This method utilizes a newly designed positioning device to ensure the precise positioning of the fibula segments in relation to each other and the mandibular stumps. The presented in-house-printed positioning device made it possible to achieve digital planning with high precision during surgery.
State of the Art in Pediatric Anesthesia: A Narrative Review about the Use of Preoperative Time
Authors: Sbaraglia Fabio , Cuomo Christian , Della Sala Filomena , Festa Rossano , Garra Rossella , Maiellare Federica , Micci Daniela Maria , Posa Domenico , Pizzo Cecilia Maria , Pusateri Angela , Spano Michelangelo Mario , Lucente Monica , Rossi Marco
Published: February 2024

This review delves into the challenge of pediatric anesthesia, underscoring the necessity for tailored perioperative approaches due to children’s distinctive anatomical and physiological characteristics. Because of the vulnerability of pediatric patients to critical incidents during anesthesia, provider skills are of primary importance. Yet, almost equal importance must be granted to the adoption of a careful preanesthetic mindset toward patients and their families that recognizes the interwoven relationship between children and parents. In this paper, the preoperative evaluation process is thoroughly examined, from the first interaction with the child to the operating day. This evaluation process includes a detailed exploration of the medical history of the patient, physical examination, optimization of preoperative therapy, and adherence to updated fasting management guidelines. This process extends to considering pharmacological or drug-free premedication, focusing on the importance of preanesthesia re-evaluation. Structural resources play a critical role in pediatric anesthesia; components of this role include emphasizing the creation of child-friendly environments and ensuring appropriate support facilities. The results of this paper support the need for standardized protocols and guidelines and encourage the centralization of practices to enhance clinical efficacy.
Laccases as Effective Tools in the Removal of Pharmaceutical Products from Aquatic Systems
Authors: Chmelová Daniela , Ondrejovič Miroslav , Miertuš Stanislav
Published: February 2024

This review aims to provide a comprehensive overview of the application of bacterial and fungal laccases for the removal of pharmaceuticals from the environment. Laccases were evaluated for their efficacy in degrading pharmaceutical substances across various categories, including analgesics, antibiotics, antiepileptics, antirheumatic drugs, cytostatics, hormones, anxiolytics, and sympatholytics. The capability of laccases to degrade or biotransform these drugs was found to be dependent on their structural characteristics. The formation of di-, oligo- and polymers of the parent compound has been observed using the laccase mediator system (LMS), which is advantageous in terms of their removal via commonly used processes in wastewater treatment plants (WWTPs). Notably, certain pharmaceuticals such as tetracycline antibiotics or estrogen hormones exhibited degradation or even mineralization when subjected to laccase treatment. Employing enzyme pretreatment mitigated the toxic effects of degradation products compared to the parent drug. However, when utilizing the LMS, careful mediator selection is essential to prevent potential increases in environment toxicity. Laccases demonstrate efficiency in pharmaceutical removal within WWTPs, operating efficiently under WWTP conditions without necessitating isolation.
N-(2,4-Difluorophenyl)-2-fluorobenzamide
Authors: Hehir Niall , Gallagher John F.
Published: February 2024

The title compound N-(2,4-difluorophenyl)-2-fluorobenzamide (Fo24) was synthesized in high yield (1.09 g; 87%) using standard synthetic procedures from the condensation reaction of 2-fluorobenzoyl chloride with 2,4-difluoroaniline. Crystals of Fo24 were grown from CH2Cl2 at room temperature. The Fo24 crystal structure was determined using single-crystal X-ray diffraction methods at 294 (1) K in space group Pn (No. 7). Fo24 is the second regular tri-fluorinated benzamide with the formula C13H8F3N1O1 to be reported and contrasts with the more common difluorinated and tetra-fluorinated analogues. In Fo24, both aromatic rings are effectively coplanar with an interplanar angle of 0.7(2)°. The central amide group plane is oriented by 23.04(18)° and 23.69(17)° from both aromatic rings, forming an intramolecular contact with an ortho-F12 atom with H1⋯F12 = 2.12(4) Å. The primary hydrogen bonds are 1D amide–amide interactions that form along the b-axis direction. In addition, weaker C-H⋯F/O interactions are noted: a R22(12) synthon involving two C-H, a N-H and two C-F groups, with C-F⋯C ring–ring stacking contacts completing the interactions.
Investigation of the Multi-Scale Deterioration Mechanisms of Anhydrite Rock Exposed to Freeze–Thaw Environment
Authors: Jin Xiaoguang , Hou Chao , He Jie , Dias Daniel
Published: February 2024

The deterioration of anhydrite rock exposed to a freeze–thaw environment is a complex process. Therefore, this paper systematically investigated the physical and mechanical evolutions of freeze–thawed anhydrite rock through a series of multi-scale laboratory tests. Meanwhile, the correlation between pore structure and macroscopic mechanical parameters was discussed, and the deterioration mechanisms of anhydrite rock under freeze–thaw cycles were revealed. The results show that with the increase in freeze–thaw processes, the mechanical strength, elastic modulus, cohesion, proportions of micropores (r ≤ 0.1 μm), and PT-Ipore throat (0–0.1 μm) decrease exponentially. In comparison, the mass variation, proportions of mesopores (0.1 μm < r < 1 μm), macropores (r ≥ 1 μm), and PT-II pore throat (0.1–4 μm) increase exponentially. After 120 cycles, the mean porosity increases by 66.27%, and there is a significant honeycomb and pitted surface phenomenon. Meanwhile, as the freeze–thaw cycles increase, the frost resistance coefficient decreases, while the damage variable increases. The correlation analysis between pore structure and macroscopic mechanical parameters shows that macropores play the most significant role in the mechanical characteristic deterioration of freeze–thawed anhydrite rock. Finally, it is revealed that the water–rock expansion and water dissolution effects play a crucial role in the multi-scale damage of anhydrite rock under the freeze–thaw environment.
Application of Composite Bars in Wooden, Full-Scale, Innovative Engineering Products—Experimental and Numerical Study
Authors: Wdowiak-Postulak Agnieszka , Świt Grzegorz , Dziedzic-Jagocka Ilona
Published: February 2024

The commercialization of modular timber products as cost-effective and lightweight components has resulted in innovative engineering products, e.g., glued laminated timber, laminated veneer lumber, I-beams, cross-laminated timber and solid timber joined with wedge joints. With the passage of time, timber structures can deteriorate, or new structural elements are required to increase the stiffness or load-bearing capacity in newly built structures, e.g., lintels over large-scale glazing or garages, or to reduce cross-sectional dimensions or save costly timber material while still achieving low weight. It is in such cases that repair or correct reinforcement is required. In this experimental and numerical study, the static performance of flexural timber beams reinforced with prestressed basalt BFRP, glass GFRP and hybrid glass–basalt fiber bars is shown. The experimental tests resulted in an increase in the load-carrying capacity of BFRP (44%), GFRP (33%) and hybrid bars (43%) and an increase in the stiffness of BFRP (28%), GFRP (24%) and hybrid bars (25%). In addition to this, glued laminated timber beams reinforced with prestressed basalt rods subjected to biological degradation, 7 years of weathering and prolonged exposure to various environmental conditions were examined, and an increase in the load-bearing capacity of 27% and an increase in stiffness of 28% were obtained. In addition, full-size laminated timber beams reinforced with prestressed basalt bars were investigated in the field as an exploratory test under fire conditions at elevated temperatures, and the effect of the physical–mechanical properties during the fire was examined via an analysis of these properties after the fire. In addition, a satisfactory correlation of the numerical simulations with the experimental studies was obtained. The differences were between 1.1% and 5.5%. The concordance was due to the fact that, in this study, the Young, Poisson and shear moduli were determined for all quality classes of sawn timber. Only a significant difference resulted in the numerical analysis for the beams exposed to fire under fire conditions. The experimental, theoretical and numerical analyses in this research were exploratory and will be expanded as directions for future research.
XFEM for Composites, Biological, and Bioinspired Materials: A Review
Authors: Vellwock Andre E. , Libonati Flavia
Published: February 2024

The eXtended finite element method (XFEM) is a powerful tool for structural mechanics, assisting engineers and designers in understanding how a material architecture responds to stresses and consequently assisting the creation of mechanically improved structures. The XFEM method has unraveled the extraordinary relationships between material topology and fracture behavior in biological and engineered materials, enhancing peculiar fracture toughening mechanisms, such as crack deflection and arrest. Despite its extensive use, a detailed revision of case studies involving XFEM with a focus on the applications rather than the method of numerical modeling is in great need. In this review, XFEM is introduced and briefly compared to other computational fracture models such as the contour integral method, virtual crack closing technique, cohesive zone model, and phase-field model, highlighting the pros and cons of the methods (e.g., numerical convergence, commercial software implementation, pre-set of crack parameters, and calculation speed). The use of XFEM in material design is demonstrated and discussed, focusing on presenting the current research on composites and biological and bioinspired materials, but also briefly introducing its application to other fields. This review concludes with a discussion of the XFEM drawbacks and provides an overview of the future perspectives of this method in applied material science research, such as the merging of XFEM and artificial intelligence techniques.
Temperature-Controlled Chain Dynamics in Polyimide Doped with CoCl2 Probed Using Dynamic Mechanical Analysis
Authors: Ionita Daniela , Cristea Mariana , Sava Ion , Popescu Maria-Cristina , Dobromir Marius , Simionescu Bogdan C.
Published: February 2024

Cobalt(II) chloride (CoCl2) being in the vicinity of polyimide chains entails modifications in terms of the molecular dynamics, which are mainly governed by the possible presence of amic acid residual groups, by the transition-metal-type characteristics of cobalt and by the CoCl2 content. Polyimide was synthesized using poly(amic acid) according to the reaction of 2,2′-bis(3,4-dicarboxylphenyl)hexafluoropropane dianhydride (6FDA) with 3,3′-dimethyl-4,4′-diaminodiphenylmethane (MMDA) in N,N-dimethylacetamide. CoCl2 was added before the thermal imidization of the poly(amic acid). An experimental approach was designed to establish the interaction between the polyimide and CoCl2 and whether the interaction depends on the quantity of the salt. Evidence for the existence of residual amic acid groups was obtained using second derivative Fourier Transform Infrared Spectroscopy (FTIR) and with the help of 2D correlation spectroscopy (2D-COS). Moreover, FTIR, along with X-ray photoelectron spectroscopy (XPS), revealed the interaction between the polymer and CoCl2, primarily in the form of Co(II)-N coordinated bonds. Nevertheless, the coordination of cobalt with suitable atoms from the amic acid groups is not precluded. The results of dynamic mechanical analysis (DMA) featured a specific relaxation assigned to the presence of CoCl2 in the polymeric film and demonstrated that its (non)reinforcing effect depends on its content in the polyimide.