bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternative Chemical Control Options and Monitoring Techniques for Triops longicaudatus (Notostraca: Triopsidae) in California Rice
Authors: Bloese Joanna B , Goding Kevin M , Godfrey Larry D
Published: October 2021

The tadpole shrimp (Triops longicaudatus (Leconte); Notostraca; Triopsidae) is a vernal pool crustacean that has emerged as a significant pest for many rice farmers in California. Currently, lambda-cyhalothrin is the commercial standard and sole management practice for TPS, but resistance appears to be emerging. Field and laboratory trials were conducted from 2015 to 2018 at the Rice Experiment Station in Biggs, California, and in greenhouses at the University of California (UC) Davis to evaluate the efficacy of several alternative chemical controls and to explore early indicators of TPS activity and damage as monitoring tools. TPS mortality in plots treated with azadirachtin was not significantly different from those in the untreated control across all trials. Copper sulfate, lambda-cyhalothrin, and clothianidin were consistently effective across both lab and field trials. Chlorantraniliprole generated effective control in four of the five trials, whereas two diflubenzuron rates generated adequate control in the field, but not in laboratory bioassays. Thus, there appear to be several effective alternative control options available for farmers, should resistance to lambda-cyhalothrin continue to spread. Water turbidity (measured using a scale of 1–4) and the number of dislodged seedlings were both significantly correlated with TPS counts in field studies. Turbidity exhibited the highest correlations with TPS counts, suggesting that with further refinement it could play a valuable role in monitoring TPS populations.
Reducing Burnout and Resignations among Frontline Workers: A Field Experiment
Authors: Linos Elizabeth , Ruffini Krista , Wilcoxen Stephanie
Published: October 2021

Government agencies around the world struggle to retain frontline workers, as high job demands and low job resources contribute to persistently high rates of employee burnout. Although four decades of research have documented the predictors and potential costs of frontline worker burnout, we have limited causal evidence on strategies that reduce it. In this article, we report on a multicity field experiment (n = 536) aimed at increasing perceived social support and affirming belonging among 911 dispatchers. We find that a 6-week intervention that prompts dispatchers to share advice anonymously and asynchronously with their peers in other cities reduces burnout by 8 points (0.4 standard deviations) and cuts resignations by more than half (3.4 percentage points) 4 months after the intervention ended. We provide supporting evidence that the intervention operates by increasing perceived social support and belonging in an online laboratory experiment (n = 497). These findings suggest that low-cost belonging affirmation techniques can reduce frontline worker burnout and help agencies retain workers, saving a mid-sized city at least $400,000 in personnel costs.
Delayed-Onset Neuropathological Complications From a Foramen Magnum and Occipital Crest Focused Traumatic Brain Injury of the Vietnam War and Other Conflicts: Part I, Case Report
Authors: Burkle Frederick M , Hadley Kevin S , Ridge Leah L , Herman Jan K , Kobeissy Firas H
Published: October 2021

Introduction

The diagnosis of traumatic brain injuries is typically based on hemispheric blasts resulting in degrees of unconsciousness and associated cerebral injuries. This case report describes a Vietnam War era setting in which a traumatic blast wave struck the posterior cranium in the region of the foramen magnum, occipital crest, and other skull openings (orbit, oronasal, and ear) and the unique secondary clinical signs and symptoms experienced over time.

Materials and Methods

This case report describes secondary delayed-onset clinical signs and symptoms consistent with progressive decades-long physical and functional complications. The traumatic blast resulted in brief unconsciousness, decreased vision in left eye, confusion, right sided hemotympanum, deafness, severe tinnitus, severe nasopharynx pain and difficulty swallowing, pain in right posterior and occipital area of the head, and loss of dental amalgams. Subsequent exams revealed progressive hyperacusis, sea sickness, dysdiadochokinesis, diagnosis of 9th and 10th cranial nerve traumatic schwannomas, hyperdense changes to the frontal lobe white matter, progressive tinnitus, chronic vertigo, right-sided high-frequency hearing loss, progressive oculo-gyric crisis of Tumarkin-like seizures, left-sided chronic vitreous hemorrhage, and diminished right hemisphere performance of the brain based on neurophysiological assessment. No post-traumatic stress, depression, or other emotional or psychiatric difficulties were claimed.

Conclusion

This case report, unique to the English language scientific literature, discusses in detail the secondary signs and symptoms of a foramen magnum and occipital crest focused-associated blast injury.
Reducing Stress and Burnout in Military Healthcare Professionals Through Mind–Body Medicine: A Pilot Program
Authors: Ram Vasudha , Bhakta Jagruti P , Roesch Scott , Millegan Jeffrey
Published: October 2021

Introduction

A 6-week mindfulness training course, the Mind–Body Medicine (MBM) pilot program for staff, was implemented at a large military treatment facility to examine the preliminary efficacy of the program in reducing stress and burnout in military healthcare professionals.

Materials and Methods

A retrospective analysis was conducted of data collected from a single-arm prospective MBM pilot program. The program was designed to help staff members increase their awareness of burnout and its consequences and to learn how to utilize mindfulness-based self-care practices as a means for reducing stress and preventing burnout at work. Participants attended a 2-hour MBM group each week for a total duration of 6 weeks. Assessments of stress, resilience, anxiety, somatic symptoms, functional impairment, sleep quality, quality of life, and burnout were administered at baseline (T1), upon completion of the 6-week program (T2), and at least 3 months after program completion (T3). Multilevel modeling was used as the primary statistical model to assess changes in outcomes. Fifty-nine staff members completed assessments at T1, 31 (52.5%) at T2, and 17 (28.8%) at T3.

Results

Participants showed improvements on scores of perceived stress, resilience, anxiety, somatic symptoms, quality of life, and burnout variables from T1 to T2 and from T1 to T3 (P < .05). Additionally, they reported improvements in their knowledge, understanding, and utilization of MBM concepts and practices from T1 to T2 and from T1 to T3 (P < .05).

Conclusions

Results from this pilot suggest that the MBM program has the potential to reduce occupational stress and burnout and improve well-being in military healthcare professionals.
Chromoblastomycosis in Latin America and the Caribbean: Epidemiology over the past 50 years
Authors: Guevara Armando , Siqueira Nathan Pereira , Nery Andreia Ferreira , Cavalcante Leticia Rossetto da Silva , Hagen Ferry , Hahn Rosane Christine
Published: October 2021

Chromoblastomycosis is a chronic disease caused by melanized fungi that mainly affect individuals performing soil-related labor. The objective of this study was to analyze the epidemiological and clinical characteristics of chromoblastomycosis in Latin America and the Caribbean by an extensive literature review. An integrative review was performed of English, French, Portuguese, and Spanish publications in LILACS, SciELO, PubMed, SCOPUS and Web of Science databases covering the period 1969–2019. A total of 1211 articles were identified, of which 132 were included in the review, covering 2081 patients, 80.3% were males, the mean age was 56.1 years. The mean duration of the disease was 10.8 years. The lesions were mainly described in the lower limbs (60%). The most frequent clinical forms were verrucous (46.4%) and tumorous (21.7%). Major disease symptoms and signs consisted of itching and pain. Bacterial infection and functional limitation were important complications. Immunosuppression post-kidney transplantation was the most frequent comorbidity while leprosy was the main concomitant infectious disease. Fonsecaea pedrosoi and Cladophialophora carrionii were the predominant etiological agents. Majority of the cured cases were treated with itraconazole as monotherapy or in combination with other antifungals, surgery or cryosurgery. Chromoblastomycosis affects hundreds of rural workers in Latin America and the Caribbean, causing disability and personal, family and economic losses. It is important to prioritize epidemiological surveillance and early diagnosis of this disease in order to reveal its real prevalence and direct resources to preventive actions, diagnosis and early treatment.

Lay summary

Chromoblastomycosis is a slowly progressing chronic disease caused by melanized fungi. We collected data from South America and the Caribbean covering 1969–2019, the 132 articles included 2081 patients, mean disease duration was 10.8 years. Fonsecaea pedrosoi and Cladophialophora carrionii predominated.
Non-detection of 6Li in Spite plateau stars with ESPRESSO
Authors: Wang Ella Xi , Nordlander Thomas , Asplund Martin , Lind Karin , Zhou Yixiao , Reggiani Henrique
Published: October 2021

The detection of 6Li in Spite plateau stars contradicts the standard big bang nucleosynthesis prediction, known as the second cosmological lithium problem. We measure the isotopic ratio 6Li/7Li in three Spite plateau stars: HD 84937, HD 140283, and LP 815−43. We use 3D non-local thermodynamic equilibrium radiative transfer and for the first time apply this to high-resolution, high signal-to-noise ratio data from the ultra-stable ESPRESSO/Very Large Telescope spectrograph. These are among the best spectra ever taken of any metal-poor stars. As the measurement of 6Li/7Li is degenerate with other physical stellar parameters, we employ Markov chain Monte Carlo methods to find the probability distributions of measured parameters. As a test of systematics, we also use three different fitting methods. We do not detect 6Li in any of the three stars, and find consistent results between our different methods. We estimate 2σ upper limits to 6Li/7Li of 0.7, 0.6, and 1.7 per cent, respectively, for HD 84937, HD 140283, and LP 815−43. Our results indicate that there is no second cosmological lithium problem, as there is no evidence of 6Li in Spite plateau stars.
Is the orbit of the exoplanet WASP-43b really decaying? TESS and MuSCAT2 observations confirm no detection
Authors: Garai Z , Pribulla T , Parviainen H , Pallé E , Claret A , Szigeti L , Béjar V J S , Casasayas-Barris N , Crouzet N , Fukui A , Chen G , Kawauchi K , Klagyivik P , Kurita S , Kusakabe N , de Leon J P , Livingston J H , Luque R , Mori M , Murgas F , Narita N , Nishiumi T , Oshagh M , Szabó Gy M , Tamura M , Terada Y , Watanabe N
Published: October 2021

Up to now, WASP-12b is the only hot Jupiter confirmed to have a decaying orbit. The case of WASP-43b is still under debate. Recent studies preferred or ruled out the orbital decay scenario, but further precise transit timing observations are needed to definitively confirm or refute the period change of WASP-43b. This possibility is given by the Transiting Exoplanet Survey Satellite (TESS) space telescope. In this work, we used the available TESS data, multicolour photometry data obtained with the Multicolor Simultaneous Camera for studying Atmospheres of Transiting exoplanets 2 (MuSCAT2) and literature data to calculate the period change rate of WASP-43b and to improve its precision, and to refine the parameters of the WASP-43 planetary system. Based on the observed-minus-calculated data of 129 mid-transit times in total, covering a time baseline of about 10 yr, we obtained an improved period change rate of $\dot{P} = -0.6 \pm 1.2$ ms yr−1 that is consistent with a constant period well within 1σ. We conclude that new TESS and MuSCAT2 observations confirm no detection of WASP-43b orbital decay.
3D MHD simulations of the supernova remnant CTB 109
Authors: Castellanos-Ramírez A , Velázquez P F , Cantó J
Published: October 2021

We examine the evolution and emission of the supernova remnant (SNR) CTB 109 using 3D magnetohydrodynamics simulations. The SNR evolves in a medium divided by a plane interface into two media with different densities and pressure equilibrium. Our results reveal that a remnant with the characteristics of CTB 109 is formed provided the supernova (SN) explosion takes place in the less dense medium and also if the interstellar magnetic field (ISMF) is almost uniform. Finally, we conclude that the quasi-parallel mechanism can explain the brightness synchrotron emission and the position angle of the projected ISMF reported in previous works.
Eclipse timing variation analysis of OGLE-IV eclipsing binaries towards the Galactic Bulge – II. Short periodic triple stellar systems
Authors: Hajdu T , Borkovits T , Forgács-Dajka E , Sztakovics J , Bódi A
Published: October 2021

We report an eclipse timing variations (ETV) study to identify close, stellar mass companions to the eclipsing binaries monitored during the photometric survey Optical Gravitational Lensing Experiment-IV. We also present an alternative automatic way to determine the first and last contacts of an eclipse. Applying the phase dispersion minimization method to identify potential triples, we find close third components with outer periods in less than 1500 d in 23 systems. We present outer orbit solution for 21 of 23 systems. For the 10 tightest triples, we find that the ETV can only be modelled with the combination of the light-travel-time effect (LTTE) and third-body perturbations, while in case of another 11 systems, pure LTTE solutions are found to be satisfactory. In the remaining two systems, we identify extra eclipses connected to the outer component, but for the incomplete and noisy ETV curves, we are unable to find realistic three-body solutions. Therefore, in these cases we give only the outer period.
MUSEQuBES: characterizing the circumgalactic medium of redshift ≈3.3 Ly α emitters
Authors: Muzahid Sowgat , Schaye Joop , Cantalupo Sebastiano , Marino Raffaella Anna , Bouché Nicolas F , Johnson Sean , Maseda Michael , Wendt Martin , Wisotzki Lutz , Zabl Johannes
Published: October 2021

We present the first characterization of the circumgalactic medium of Ly α emitters (LAEs), using a sample of 96 z ≈ 3.3 LAEs detected with the VLT/MUSE in fields centred on eight bright background quasars. The LAEs have low Ly α luminosities ($\sim 10^{42}\, \text{erg}\, \text{s}^{-1}$) and star formation rates (SFRs) $\sim 1~\text{M}_\odot \, \text{yr}^{-1}$, which for main-sequence galaxies correspond to stellar masses of only $\sim 10^{8.6}\, \text{M}_\odot$. The median transverse distance between the LAEs and the quasar sightlines is 165 proper kpc (pkpc). We stacked the high-resolution quasar spectra and measured significant excess H i and C iv absorption near the LAEs out to 500 $\text{km}\, \text{s}^{-1}$ and at least ≈250 pkpc (corresponding to ≈7 virial radii). At $\lesssim 30~\text{km}\, \text{s}^{-1}$ from the galaxies, the median H i and C iv optical depths are enhanced by an order of magnitude. The absorption is significantly stronger around the ≈1/3 of our LAEs that are part of ‘groups’, which we attribute to the large-scale structures in which they are embedded. We do not detect any strong dependence of either the H i or C iv absorption on transverse distance (over the range ≈50–250 pkpc), redshift, or the properties of the Ly α emission line (luminosity, full width at half-maximum, or equivalent width). However, for H i, but not C iv, the absorption at $\lesssim 100\, \text{km}\, \text{s}^{-1}$ from the LAE does increase with the SFR. This suggests that LAEs surrounded by more H i tend to have higher SFRs.
G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils
Authors: Guo Fang , He Yongpei , Fan Yixian , Du Zhenzhen , Sun Huanhuan , Feng Zuohua , Zhang Guimei , Xiong Ting
Published: October 2021

Evidence accumulated in recent years has revealed that neutrophils are involved in the initial establishment of endometriosis, which is well-known as a chronic inflammatory disease. So far, why and how neutrophils promote the formation of early endometriosis are still unclear. In this study, using a mouse model of endometriosis, we demonstrated that endometriosis mice (EMs mice) had a significantly increased number of neutrophils in peritoneal fluids and lesions, and increased levels of granulocyte colony-stimulating factor (G-CSF) and IL-6 in serum and peritoneal fluids compared to the control group. In the neutrophils and uterine fragments co-injection experiment, neutrophils regulated by G-CSF and IL-6 had a similar effect to neutrophils from EMs mice, increasing the number, area, weight and microvessel density (MVD) of endometriotic lesions. Blocking the effect of G-CSF and IL-6 in EMs mice resulted in a decrease in the number, area and weight of endometriotic lesions. Following the depletion of neutrophils in vivo using a anti-Ly6G antibody, the MVD in the lesions of mice treated with neutrophils from EMs mice and neutrophils from pG/pI6 mice were significantly reduced. Neutrophils from EMs mice and neutrophils from pG/pI6 mice altered the expression levels of Mmp9, Bv8 and Trail genes compared to the neutrophils from PBS-treated mice. IL-6 together with G-CSF induced a higher expression of phospho-STAT3 and STAT3 in neutrophils. These findings suggest that neutrophils modulated by G-CSF and IL-6 through the STAT3 pathway alter the expression levels of the angiogenesis-related genes Mmp9, Bv8 and Trail, and may promote the establishment of early endometriosis.
COVID-19 survivors with calcineurin-inhibitors-treated rheumatoid arthritis
Authors: Kobayashi Hiroshi , Hirai Yuji , Aoki Akiko
Published: October 2021

We report two cases recovered from coronavirus disease 2019 with rheumatoid arthritis which had been in remission or low disease activity by taking calcineurin inhibitor (CNI). Both cases had moderate to severe pneumonia treated with intravenous dexamethasone or in the severe case remdesivir in addition to it. These cases suggest that the use of CNI may have affected the improvement of severe pneumonia.
Retrograde Suction Decompression for Clipping of a Giant Ophthalmic Internal Carotid Artery Aneurysm: 2-Dimensional Operative Video
Authors: Srinivasan Visish M , Zhang Michael , Scherschinski Lea , Whiting Alexander C , Labib Mohamed A , Lawton Michael T
Published: October 2021

Microsurgical clipping of large paraclinoid aneurysms is challenging because of the complex anatomy of the dural rings, lack of easy proximal control, and wide aneurysm necks. Proximal retrograde suction decompression, or the Dallas technique, can reduce aneurysm turgor and, with aspiration of the trapped cervical and supraclinoid internal carotid arteries (ICAs), can collapse the aneurysm to aid microsurgical clipping.
1-5

 A woman in her late 30s presented with decreased right-eye visual acuity. Informed written consent was obtained for microsurgical management and publication. Upon cervical exposure of the carotid bifurcation, we performed a standard pterional craniotomy, trans-sylvian exposure, and intradural anterior clinoidectomy. After burst suppression and cross-clamping of the carotid, we inserted an angiocatheter at the common carotid artery (CCA). Distal temporary clips were placed on the posterior communicating artery and C7 ICA. With the cervical ICA unclamped, retrograde suction was continuously applied to deflate the aneurysm. We applied 2 pairs of fenestrated-booster clips to the aneurysm dome and a fifth clip to the aneurysm neck. After restoration of flow, indocyanine green angiography and Doppler assessments were performed. The proximal clip was converted into a curved clip to optimize ICA flow.

 Postoperative angiography confirmed complete occlusion of the aneurysm. The patient was discharged on postoperative day 3, with stable visual acuity.
6
This video demonstrates that retrograde suction decompression via the cervical CCA can be safely performed to facilitate clipping of complex paraclinoid ICA aneurysms. Comprehensive planning of temporary aneurysm trapping for suction decompression and permanent clip construct for aneurysm occlusion are needed for effective aneurysm repair.
Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain—An Exploratory Study
Authors: Teixeira Paulo E P , Pacheco-Barrios Kevin , Uygur-Kucukseymen Elif , Machado Roberto Mathias , Balbuena-Pareja Ana , Giannoni-Luza Stefano , Luna-Cuadros Maria Alejandra , Cardenas-Rojas Alejandra , Gonzalez-Mego Paola , Mejia-Pando Piero F , Wagner Timothy , Dipietro Laura , Fregni Felipe
Published: October 2021

Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship.

Objective

To investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms.

Design

Cross-sectional analysis.

Participants

Thirty NSCLBP patients participated.

Methods

Self-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis.

Results

CPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression.

Conclusions

Faster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.
Cervical Multifidus Morphology and Quality Are Not Associated with Clinical Variables in Women with Fibromyalgia: An Observational Study
Authors: Valera-Calero Juan Antonio , Úbeda-D'Ocasar Edurne , Caballero-Corella Mario , Fernández-de-las-Peñas César , Sendarrubias Gracia María Gallego , Arias-Buría José Luis
Published: October 2021

Objective

Some studies have reported the presence of histological alterations, such as myofiber disorganization and abnormalities in the number and shape of mitochondria, in patients with fibromyalgia syndrome (FMS). Although Ultrasound imaging (US) is used to quantitatively characterize muscle tissues, US studies in patients with FMS are lacking. Therefore, we aimed to describe morphological and qualitative cervical multifidus (CM) muscle US features in women with FMS and to assess their correlation with clinical indicators.

Design

Observational study.

Setting

AFINSYFACRO Fibromyalgia Association (Madrid, Spain).

Subjects

Forty-five women with FMS participated.

Methods

Sociodemographic variables (e.g., age, height, weight, body mass index) and clinical outcomes (e.g., pain as assessed on a numerical pain rating scale, evolution time, pain-related disability as assessed by the Fibromyalgia Impact Questionnaire) were collected. Images were acquired bilaterally at the cervical spine (C4–C5 level) and measured by an experienced examiner for assessment of muscle morphology (e.g., cross-sectional area, perimeter, and shape) and quality (mean echo intensity and intramuscular fatty infiltration). Side-to-side comparisons and a correlational analysis were conducted.

Results

No significant side-to-side differences were found for morphology or quality features (P > 0.05). None of the clinical indicators were associated with US characteristics (all, P > 0.05).

Conclusion

Our results showed no side-to-side differences for CM morphology and quality as assessed with US. No associations between CM muscle morphology or quality and Fibromyalgia Impact Questionnaire, pressure pain threshold, numerical pain rating scale score, or evolution time were observed. Our preliminary data suggest that muscle morphology is not directly related to pain and pain-related disability in women with FMS.
A strategy for school reopening in the Philippines: Lessons from other countries
Authors: Maboloc Christopher Ryan
Published: October 2021

The Philippine government has not announced a strategy for a safe return to in-person instruction. A gradual approach, beginning in low-risk areas, at 50% capacity for every classroom, with students divided into two groups and alternating between in-person and online instruction every 2 weeks, is proposed. A safe return to in-person instruction in schools for millions of students in the Philippines is consistent with the concept of equity in education.
Policy Effects of International Taxation on Firm Dynamics and Capital Structure
Authors: Spencer Adam Hal
Published: October 2021

This article develops a quantitative open economy framework with dynamics, firm heterogeneity and financial frictions to study the impact of corporate tax reforms targeted at multinationals. The model quantifies their impact on firm selection, production and welfare. Firms draw idiosyncratic shocks, invest in capital, choose optimal financing and select endogenously into selling abroad, through exporting or FDI. I apply this framework to the removal of the U.S. repatriation tax as in the Tax Cuts and Jobs Act. The reform’s impact trades-off two selection effects—more offshoring versus greater U.S. business dynamism. The reform leads to higher U.S. welfare at little cost to the Treasury. A series of exercises illustrate that the novel features of this framework have significant quantitative implications. The reform gives starkly different cross-sectional predictions and lower welfare gains when financial frictions are removed and it is welfare reducing in a static counterpart of the model.
ESTIMATION OF PATIENT RADIATION DOSES FROM MULTI-DETECTOR COMPUTED TOMOGRAPHY ANGIOGRAPHY PROCEDURES IN TANZANIA
Authors: Ngaile J E , Msaki P K , Suleiman S A , Chuma F M , Muhogora W E , Jusabani A M
Published: October 2021

The aim of the present study was to estimate the volume CT dose index (CTDIvol), dose length product (DLP) and effective dose (ED) to patients from five multi-detector computed tomography angiography (MDCTA) procedures: brain, carotid, coronary, entire aorta and lower limb from four medical institutions in Tanzania; to compare these doses to those reported in the literature, and to compare the data obtained with ICRP 103 and Monte Carlo software. The radiation doses for 217 patients were estimated using patient demographics, patient-related exposure parameters, the geometry of examination and CT-Expo V 2.4 Monte Carlo-based software. The median values of the CTDIvol, DLP and ED for MDCTA procedures of the brain and carotids were 36.8 mGy, 1481.0 mGy∙cm and 5.2 mSv, and 15.9 mGy, 1224.0 mGy∙cm and 7.8 mSv, respectively; while for the coronary, entire aortic, and lower limbs were 49.4 mGy, 1493.0 mGy∙cm and 30.6 mSv; 16.2 mGy, 2287.0 mGy∙cm and 41.1 mSv; and 6.4 mGy, 1406.0 mGy∙cm and 10.5 mSv, respectively. The ratio of the maximum to minimum ED values to individual patients across the four medical centers were 41.4, 11.1, 4.6, 9.5 and 37.4, respectively, for the brain, carotid, coronary, entire aortic and lower limb CT angiography procedures. The mean values of CTDIvol, DLP and ED in the present study were typically higher than the values reported from Kenya, Korea and Saudi Arabia. The 75th percentile values of the DLP were above the preliminary diagnostic references levels proposed by Kenya, Switzerland and Korea. The observed wide range of examination scanning protocols and patient doses for similar MDCTA procedures within and across hospitals; and the observed relatively high patient doses compared to those reported in the literature, call for the need to standardize scanning protocols and optimise patient dose from MDCTA procedures.
Trends in Consultations for Schizophrenia and Non-affective Psychoses in Italian Emergency Departments During and After the 2020 COVID-19 Lockdown
Authors: Balestrieri Matteo , Rucci Paola , Amendola Davide , Bonizzoni Miki , Cerveri Giancarlo , Colli Chiara , Da Re Maria , Dragogna Filippo , Ducci Giuseppe , Elmo Maria Giuseppa , Ghio Lucio , Grasso Federico , Locatelli Clara , Mencacci Claudio , Monaco Leonardo , Nicotra Alessandra , Piccinini Giulia , Toscano Marco , Vaggi Marco , Villari Vincenzo , Vitalucci Alberto , Castelpietra Giulio , Bondi Emi
Published: October 2021

Aims

To analyze the hospital emergency department (HED) consultations for schizophrenia-spectrum disorders in nine Italian hospitals during the 2020 lockdown and postlockdown periods, compared to the equivalent periods in 2019.

Methods

Characteristics of consultations, patients, and drug prescriptions were analyzed. Joinpoint models were used to identify changes in the weekly trend of consultations.

Results

During the 2020 lockdown the overall number of HED consultations for schizophrenia decreased by 40.7% and after the lockdown by 12.2% compared with 2019. No difference was found in the proportion of consultations that led to GHPU admissions or compulsory admissions. Suicidality rates did not differ across the two years, with the exception of ideations and plans (+5.9%) during the postlockdown period. We found an increase in benzodiazepine prescriptions in 2020 during the lockdown and postlockdown periods (+10.6% and +20.8%, respectively), and a decrease of prescriptions for short-acting sedative agents in the postlockdown period (–7.9%). An increase in the weekly trend of consultations occurred from March 11 to 17 (week 11) till June 26 to 30 (week 26). As a result, the initial gap in the number of consultations between the 2 years canceled out at the end of June.

Conclusions

HED consultation rate for schizophrenia-spectrum disorders declined consistent with that of other psychiatric disorders. In the postlockdown period, the growth of suicidal ideation/planning and increase in the prescriptions of anxiolytic-sedating drugs may foreshadow that for some schizophrenia patients the exit from the lockdown period is not liberating, but rather a source of agitation or perturbation.
Characterization of indoor arenas through an anonymous survey
Authors: McGill Staci , Hayes Morgan , Tumlin Kimberly , Coleman Robert
Published: October 2021

Equine farms are building both stables for the horses to live in and additional facilities to train and work horses (Kidd et al., 1997). For many of these farms, an outdoor arena that has an all-weather footing is the first working facility built. During inclement weather the ability to train in the outdoor arenas is inhibited, which in turn means the trainers, riders, and farms lose income as money is only made when horses are working, training, and competing. Indoor arenas allow for horses to continue to be worked no matter the weather conditions. The equine industry contributes a total of $122 billion dollars a year to the United States’ economy. The expenditures to build and maintain these arenas the horses utilize for training and work are a portion of the equine economic contribution (American Horse Council Foundation, 2018). During the summer of 2018, an anonymous online survey was conducted to begin to characterize indoor arenas. Owners, managers, and riders were questioned on a variety of topics including arena construction and design, arena usage, footing type, maintenance practices, environmental concerns, and potential health issues experienced within the facilities. Respondents in the study defined indoor arenas differently depending on geographic region, however most definitions included a roof, some enclosure, and footing in order to work the horses. In addition, of the 335 respondents of the survey, 71% or 239 respondents reported having concerns about the environment within the indoor arena. The three main concerns are dust, moisture, and lack of air movement. Overall, the survey begins to build our understanding regarding these facilities and provides the framework to continue research in the future.
Drought affects the fate of non-structural carbohydrates in hinoki cypress
Authors: Tsuji Chiaki , Dannoura Masako , Desalme Dorine , Angeli Nicolas , Takanashi Satoru , Kominami Yuji , Epron Daniel
Published: October 2021

Tree species that close stomata early in response to drought are likely to suffer from an imbalance between limited carbohydrate supply due to reduced photosynthesis and metabolic demand. Our objective was to clarify the dynamic responses of non-structural carbohydrates to drought in a water-saving species, the hinoki cypress (Chamaecyparis obtusa Sieb. et Zucc.). To this end, we pulse-labeled young trees with 13CO2 10 days after the beginning of the drought treatment. Trees were harvested 7 days later, early during drought progression, and 86 days later when they had suffered from a long and severe drought. The labeled carbon (C) was traced in phloem extract, in the organic matter and starch of all the organs, and in the soluble sugars (sucrose, glucose and fructose) of the most metabolically active organs (foliage, green branches and fine roots). No drought-related changes in labeled C partitioning between belowground and aboveground organs were observed. The C allocation between non-structural carbohydrates was altered early during drought progression: starch concentration was lower by half in the photosynthetic organs, while the concentration of almost all soluble sugars tended to increase. The preferential allocation of labeled C to glucose and fructose reflected an increased demand for soluble sugars for osmotic adjustment. After 3 months of a lethal drought, the concentrations of soluble sugars and starch were admittedly lower in drought-stressed trees than in the controls, but the pool of non-structural carbohydrates was far from completely depleted. However, the allocation to storage had been impaired by drought; photosynthesis and the sugar translocation rate had also been reduced by drought. Failure to maintain cell turgor through osmoregulation and to refill embolized xylem due to the depletion in soluble sugars in the roots could have resulted in tree mortality in hinoki cypress, though the total pool of carbohydrate was not completely depleted.
Greater hydraulic safety contributes to higher growth resilience to drought across seven pine species in a semi-arid environment
Authors: Duan Chun-Yang , Li Ming-Yong , Fang Li-Dong , Cao Yu , Wu De-Dong , Liu Hui , Ye Qing , Hao Guang-You
Published: October 2021

Quantifying inter-specific variations of tree resilience to drought and revealing the underlying mechanisms are of great importance to the understanding of forest functionality, particularly in water-limited regions. So far, comprehensive studies incorporating investigations in inter-specific variations of long-term growth patterns of trees and the underlying physiological mechanisms are very limited. Here, in a semi-arid site of northern China, tree radial growth rate, inter-annual tree-ring growth responses to climate variability, as well as physiological characteristics pertinent to xylem hydraulics, carbon assimilation and drought tolerance were analyzed in seven pine species growing in a common environment. Considerable inter-specific variations in radial growth rate, growth response to drought and physiological characteristics were observed among the studied species. Differently, the studied species exhibited similar degrees of resistance to drought-induced branch xylem embolism, with water potential corresponding to 50% loss hydraulic conductivity ranging from −2.31 to −2.96 MPa. We found that higher branch hydraulic efficiency is related to greater leaf photosynthetic capacity, smaller hydraulic safety margin and lower woody density (P < 0.05, linear regressions), but not related to higher tree radial growth rate (P > 0.05). Rather, species with higher hydraulic conductivity and photosynthetic capacity were more sensitive to drought stress and tended to show weaker growth resistance to extreme drought events as quantified by tree-ring analyses, which is at least partially due to a trade-off between hydraulic efficiency and safety across species. This study thus demonstrates the importance of drought resilience rather than instantaneous water and carbon flux capacity in determining tree growth in water-limited environments.
Distribution of Puccinia striiformis f. sp. tritici Races and Virulence in Wheat Growing Regions of Kenya from 1970 to 2014
Authors: Wamalwa Mercy N. , Wanyera Ruth , Rodriguez-Algaba Julian , Boyd Lesley A. , Owuoche James , Ogendo Joshua , Bhavani Sridhar , Uauy Cristobal , Justesen Annemarie F. , Hovmøller Mogens
Published: October 2021

Stripe rust, caused by the fungal pathogen Puccinia striiformis f. sp. tritici, is a major threat to wheat (Triticum spp.) production worldwide. The objective of this study was to determine the virulence of P. striiformis f. sp. tritici races prevalent in the main wheat growing regions of Kenya, which includes Mt. Kenya, Eastern Kenya, and the Rift Valley (Central, Southern, and Northern Rift). Fifty P. striiformis f. sp. tritici isolates collected from 1970 to 1992 and from 2009 to 2014 were virulence phenotyped with stripe rust differential sets, and 45 isolates were genotyped with sequence characterized amplified region (SCAR) markers to differentiate the isolates and identify aggressive strains PstS1 and PstS2. Virulence corresponding to stripe rust resistance genes Yr1, Yr2, Yr3, Yr6, Yr7, Yr8, Yr9, Yr17, Yr25, and Yr27 and the seedling resistance in genotype Avocet S were detected. Ten races were detected in the P. striiformis f. sp. tritici samples obtained from 1970 to 1992, and three additional races were detected from 2009 to 2014, with a single race being detected in both periods. The SCAR markers detected both Pst1 and Pst2 strains in the collection. Increasing P. striiformis f. sp. tritici virulence was found in the Kenyan P. striiformis f. sp. tritici population, and different P. striiformis f. sp. tritici race groups were found to dominate different wheat growing regions. Moreover, recent P. striiformis f. sp. tritici races in East Africa indicated possible migration of some race groups into Kenya from other regions. This study is important in elucidating P. striiformis f. sp. tritici evolution and virulence diversity and useful in breeding wheat cultivars with effective resistance to stripe rust.
Original Research: Suicidal Ideation and Attitudes Toward Help Seeking in U.S. Nurses Relative to the General Working Population
Authors: Kelsey Elizabeth A. , West Colin P. , Cipriano Pamela F. , Peterson Cheryl , Satele Daniel , Shanafelt Tait , Dyrbye Liselotte N.
Published: October 2021

Purpose:

Although previous studies have revealed professional consequences of burnout among nurses, less is known about the potential personal consequences. This study investigated the prevalence of suicidal ideation and attitudes toward help seeking among U.S. nurses relative to other workers, and the extent to which personal and professional factors, including burnout, were related to suicidal ideation.

Methods:

In November 2017, a cross-sectional survey was sent to 86,858 nurses who were members of the American Nurses Association and to a probability-based sample of 5,198 U.S. workers. The survey included questions regarding suicidal ideation, burnout, symptoms of depression, individual and professional characteristics, and willingness to seek professional help if a serious emotional problem arose. Multivariable logistic regression analyses were conducted to identify factors associated with suicidal ideation after controlling for other factors.

Results:

Among the 7,378 nurse respondents, 403 (5.5%) reported having suicidal ideation within the past year. Most nurses (84.2%) indicated willingness to seek professional help for a serious emotional problem. Yet nurses with suicidal ideation were less likely to report that they'd seek such help (72.6%) than nurses without suicidal ideation (85%). In a multivariable analysis of nurses' data, after controlling for other personal and professional characteristics, we found that burnout was strongly associated with suicidal ideation. Adjusted combined multivariable analyses showed that nurses were more likely than other workers to have suicidal ideation. Both nurses and other workers who reported suicidal ideation were less likely to seek help than were those who did not report such ideation.

Conclusions:

Compared with other U.S. workers, nurses are at higher risk for suicidal ideation, and nurses with such ideation are more reluctant to seek help than those without it. Burnout contributes to the risk of suicidal ideation. These issues warrant greater attention. Systems- and practice-level interventions must be identified and implemented, both to address the higher prevalences of burnout and suicidal ideation in nurses and to mitigate the stigma about mental health problems and other barriers to seeking help.
Comparison of a preservative-free nonsteroidal anti-inflammatory drug and preservative-free corticosteroid after uneventful cataract surgery: multicenter, randomized, evaluator-blinded clinical trial
Authors: Kim Seonjoo , Ko Byung-Yi , Koh Jae Woong , Kim Eun Chul , Kim Hong Kyun , Shin Young Joo , Song Jong-Suk , Lee Do Hyung , Lee Ji Eun , Lee Hyung Keun , Chung So-Hyang , Kim Hyun Seung
Published: October 2021

Purpose:

To compare the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal eyedrops for inflammation management after cataract surgery using slitlamp indicators.

Setting:

11 eye centers in South Korea.

Design:

Randomized prospective multicenter study with a blinded evaluator.

Method:

In 125 (250 eyes) patients who underwent cataract surgery, bromfenac sodium hydrate 0.1% (NSAID group) was applied twice a day in 1 eye, whereas the other eye was treated with fluorometholone 0.1% (steroid group), 4 times a day for 4 weeks postoperatively. The primary efficacy outcome was the presence of anterior chamber cells and flare at 1 week postoperatively. Anterior chamber cells and flare at 4 to 8 weeks, corrected distance visual acuity, central corneal thickness, conjunctival hyperemia, dry eye parameters, foveal thickness, and ocular and visual discomfort were evaluated as secondary outcomes.

Results:

At week 1, residual anterior chamber inflammation was not statistically significantly different between the groups (−1.03 ± 1.27 vs −0.95 ± 1.24, P = .4850). However, the NSAID group recovered from conjunctival hyperemia more rapidly than the steroid group (0.30 ± 0.52 vs 0.44 ± 0.81, P = .0144 at week 1). The increase in central corneal thickness in the NSAID group was less than that in the steroid group 1 week postoperatively (7.87 ± 22.46 vs 29.47 ± 46.60 μm, P < .0001). The change in foveal thickness in the NSAID group was significantly less than that in the steroid group (18.11 ± 68.19 vs 22.25 ± 42.37 μm, P = .0002). Lower levels of postoperative ocular and visual discomfort were reported in the NSAID group than in the steroid group under treatment.

Conclusions:

Preservative-free bromfenac was as effective as preservative-free fluorometholone eyedrops in anterior chamber inflammation control and showed better signs and symptoms after cataract surgery.
Dyslipidemia and aortic valve disease
Authors: Mata Pedro , Alonso Rodrigo , Pérez de Isla Leopoldo , Badimón Lina
Published: October 2021

Purpose of review

Degenerative aortic stenosis (AS) is one of the most prevalent heart valve diseases in the adult population. The understanding of AS pathophysiology and involved risk factors have recently undergone a great advance, with low-density lipoprotein cholesterol (LDL-C), lipoprotein (a) [Lp(a)] and other clinical conditions taking on a relevant role. Although little is known about the prevention of AS, we can progressively find more evidence of the possible use of drugs to control risk factors as tools that may delay the progression to severe AS and aortic valve replacement.

Recent findings

Several factors have shown to be solid predictors of the development of AS. Mendelian randomization and observational studies on risk factors specifically lipid factors, such as hypercholesterolemia, Lp(a), proprotein convertase subtilisin/kexin type 9 and hypertension have provided meaningful new information. The SAFEHEART study has significantly contributed to define the role of LDL-C and Lp(a) in AS.

In this review we discuss the interrelationship of dyslipidemia, especially hypercholesterolemia and Lp(a) in the development and prognosis of valvular AS. New imaging tools may contribute to its early detection. Future studies with proprotein convertase subtilisin/kexin type 9 inhibitors and specific therapies to lower Lp(a) might contribute to delay AS development.
Chronic rejection as a persisting phantom menace in organ transplantation: a new hope in the microbiota?
Authors: Mongodin Emmanuel F. , Saxena Vikas , Iyyathurai Jegan , Lakhan Ram , Ma Bing , Silverman Emma , Lee Zachariah L. , Bromberg Jonathan S.
Published: October 2021

Purpose of review

The microbiota plays an important role in health and disease. During organ transplantation, perturbations in microbiota influence transplant outcome. We review recent advances in characterizing microbiota and studies on regulation of intestinal epithelial barrier function and mucosal and systemic immunity by microbiota and their metabolites. We discuss implications of these interactions on transplant outcomes.

Recent findings

Metagenomic approaches have helped the research community identify beneficial and harmful organisms. Microbiota regulates intestinal epithelial functions. Signals released by epithelial cells or microbiota trigger pro-inflammatory or anti-inflammatory effects on innate and adaptive immune cells, influencing the structure and function of the immune system. Assessment and manipulation of microbiota can be used for biomarkers for diagnosis, prognosis, and therapy.

The bidirectional dialogue between the microbiota and immune system is a major influence on immunity. It can be targeted for biomarkers or therapy. Recent studies highlight a close association of transplant outcomes with microbiota, suggesting exciting potential avenues for management of host physiology and organ transplantation.