bluuebunny/crossref_metadata_2025 huggingface dataset:
Impactos Psicossociais e na Qualidade de Vida do Tratamento Oncológico em Crianças e Adolescentes
Authors: Pereira Clara Ignácio Pessoa , Nascimento Isadora Bolela , Cruz Aristides Schier da , Volc Sahlua Miguel , Tormen Tiago Hessel
Published: August 2023

Introdução: Tão importante quanto o diagnóstico e o tratamento do câncer pediátrico são os cuidados relacionados ao impacto psicossocial, educacional e emocional. Objetivo: Avaliar em crianças e adolescentes com diagnóstico de câncer os impactos psicossociais, de qualidade de vida e da presença de acompanhante durante os procedimentos. Método: Estudo transversal, descritivo, com pacientes de 8 a 18 anos e diagnóstico de neoplasia maligna. Os pacientes responderam aos questionários: PedsQL 4.0 Qualidade de Vida (8 a 12 anos), PedsQL 3.0 Módulo de Câncer (8 a 12 anos), PedsQL 4.0 Qualidade de Vida (13 a 18 anos), PedsQL 3.0 Módulo de Câncer (13 a 18 anos) e outro sobre acompanhantes elaborado pelos autores. Resultados: Foram incluídos 25 pacientes pediátricos oncológicos que se sentiam mais felizes na presença de um acompanhante e menos ansiosos durante os procedimentos. Foi percebido grande impacto na qualidade de vida. No questionário Qualidade de Vida, não houve diferença significativa (p=0,627) entre os grupos de pacientes com 8 a 12 anos e 13 a 18 anos, porém o grupo com 8 a 12 anos teve impacto significativamente maior no questionário Módulo de Câncer (p=0,0094). Conclusão: O impacto psicossocial e na qualidade de vida é razoavelmente grande em pacientes pediátricos oncológicos. Além disso, os mais jovens parecem sofrer um impacto psicossocial maior. Os pacientes se dizem mais felizes com a presença de acompanhante, e mais ansiosos na sua ausência.
Implementasi Media Big Book Dalam Mengembalikan Semangat Belajar Siswa Pasca Pandemi Pada Mata Pelajaran Akidah Akhlak Kelas VII DI MTs Tarbiyatul Islam Soko
Authors: Ahmad Mansur Ahmad Mansur , Nurul Mutmainah
Published: August 2023

It is important to restore learning during the Covid-19 pandemic to reduce learning losses. To restore students' enthusiasm for learning after the pandemic, teachers must choose the right media to make students excited and also increase the focus of learning. One of the methods used to generate enthusiasm and increase student focus is to use new learning media, namely big book media.The researcher used descriptive qualitative method. Data were obtained through unstructured and in-depth interviews, observation, and documentation. This study uses data analysis techniques in the form of data reduction, data presentation, drawing conclusions and checking the validity of the data.The results showed that students' enthusiasm for learning after the pandemic decreased. This is caused by several things, namely online learning is too long, not interested in learning methods and not using any media when learning. Meanwhile, the teacher's efforts to restore students' enthusiasm for learning after the pandemic is to combine the lecture method with big book media. Finally, learning becomes more effective, this can be seen from the increase in student literacy and the increase in students' creativity in imagining.

Keywords : Implementasi, big book media, ethusiasm for learning, post-pandemic
Finances of the Nation: Is the CWB Enhancement Achieving Its Dual Objective of Supporting Income and Incentivizing Work? The Effects for Couples in Ontario and Quebec
Authors: Godbout Luc , St-Cerny Suzie
Published: August 2023

In this article, Luc Godbout and Suzie St-Cerny focus on the effects of enhancing the Canada workers benefit (CWB) in 2021. More specifically, they seek to determine whether, for couples in Ontario and Quebec, the enhancement served to render work more rewarding (by lowering effective marginal tax rates) and to provide better income support for low-income workers (by increasing disposable income). The authors show that, while the objective of income support was achieved, the results for the objective of work incentivization were mixed, depending largely on a couple's family income level and working income split. The authors suggest how the CWB might be reformed to better fulfill its role in incentivizing work.
Policy Forum: Pensions, Retirement Incentives, and the Role of Inflation
Authors: Schirle Tammy
Published: August 2023

This article describes the role of wage and price inflation for the retirement plans and well-being of registered pension plan members. The federal Public Service Pension Plan is used as an example to illustrate how wage and price inflation can be accounted for in pension design. Alternative scenarios illustrate the importance of pension plan provisions for the standard of living afforded retirees as well as incentives to delay retirement and continue working at older ages.
Teletrabajo en la pandemia de COVID19. Un Análisis bibliométrico
Authors:   Universidad de Guadalajara, Garza Estrada Rosalinda , Cruz Covarrubias Lucila Patricia ,   Universidad de Guadalajara
Published: August 2023

El teletrabajo ha tenido un auge desmedido y en algunas organizaciones de- scontrolado por la situación de vida en la pandemia de COVID 19. La modalidad laboral ha llevado a los trabajadores de las empresas a ser trabajadores en casa o en otra instancia fuera de las instalaciones de la organización, de tiempo completo, obligatorio y con con- diciones laborales poco favorables para el trabajador. El objetivo del estudio es Identificar y reconocer al teletrabajo en la Pandemia de COVID 19. El alcance del escrito es exploratorio porque busca identificar experiencias de vida laboral, en las empresas y sus recursos humanos, durante el tiempo que se ha vivido en la Pandemia COVID 19. El análisis bibliométrico reporta experiencias favorables y desfavorables para teletrabajar.
Análisis Jurídico Normativo de la Pesca y Acuicultura en México, Colombia y Chile
Authors:   Universidad de Guadalajara, Sánchez Sotomayor Víctor Hugo , Huerta Mata Juan José ,   Universidad de Guadalajara
Published: August 2023

El presente artículo tiene como objetivo primordial el comparativo jurídico normativo más significativo de la pesca y acuicultura de México, Colombia y Chile, así como la relación de su marco jurídico teórico reglamentario respecto de la importancia de establecer un vínculo con el sector primario productivo de las actividades de pesca y acuícolas en los tres países mencionados y su aplicabilidad. Se destacan las disposiciones de orden constitucional en lo general, así como las de sus leyes reglamentarias en lo particular. La importancia que tiene la pesca y la acuacultura en la soberanía alimentaria y territorial de las naciones, así como en la seguridad nacional y por lo mismo son esenciales en la planeación nacional del desarrollo, lo fundamental de la generación de alimentos conforme a los objetivos que la pesca y la acuacultura deben tener para garantizar la ingesta de los ciudadanos y la proveeduría de proteínas de alta calidad, la conservación, restauración y el cuidado en la preservación y protección de los ecosistemas donde residan los ciudadanos y el reconocimiento a la industria acuícola como una actividad productiva que haga viable la pluralidad de la pesca y la generación de fuentes de empleos en el sector rural.
Editorial
Authors:   Universidad de Guadalajara, Ortiz Palafox Karla Haydee
Published: August 2023

Es menester importante todos los estudios relacionados con la globaliza- ción, sustentabilidad, pandemia y desarrollo de las organizaciones, dado que la crisis económica generada por la enfermedad del coronavirus (COVID- 19) re- quiere de dichos estudios que tienen un impacto importante y que son parte de una estructura productiva y empresarial a lo largo de décadas.
Konsep Manajemen dalam melestarikan Budaya Cina Benteng dalam siaran Star Radio 107,3 FM
Authors: Hendra Hendra , Angraeni Tri , HANITHA VIVIN , Yoyo Toni , Novianti Rini
Published: August 2023

Saat ini eksistensi radio sudah tidak semarak pada era sebelumnya dimasa jaya. Namun, hal tersebut seolah terbantahkan dengan adanya fakta bahwa radio tetap berkembang mengikuti zaman. Setiap daerah pun saat ini memiliki saluran radio local dan merupakan wadah yang menarik untuk diperuntukan bagi pembelajaran masyarakat, yang bekerja sama untuk tujuan bersama. Sehingga membahas budaya pun menjadi menarik bila dilakukan secara on air. Budaya cina benteng menjadi menarik untuk dibahas terutama bagaimana menjaga budaya tersebut agar tidak lekang oleh waktu dan konsep manajemen amat penting untuk dijalankan dalam hal ini. Berdasarkan hal tersebut maka dilakukan siaran on air dan streaming youtube dengan metode partisipatori dengan tema Konsep Manajemen dalam melestarikan Budaya Cina Benteng dalam siaran Star Radio 107,3FM

Dari hasil siaran yang telah dilakukan memiliki timbal balik yang positif dengan banyaknya pemirsa radio yang menyaksikan dilihat dari rating radio saat siaran dan terjadi komunikasi yang efektif antara host, narasumber dan pemirsa malalui diskusi interaktif selama acara berlangsung
Pendampingan Pengisian dan Pelaporan SPT Tahunan Orang Pribadi dan Sosialisasi Pemadanan NIK-NPWP Pada PMKM Prima Indonesia
Authors: Sinaga Imelda , Tilaar Andy Fitriyadi Dharma Tilaar , Suyarti Sri Suyarti
Published: August 2023

Penerapan pilar ketiga dari Tri Dharma Perguruan Tinggi yaitu Kegiatan Pengabdian Kepada Masyarakat dilaksanakan STIE Gentiaras dengan mitranya PMKM Prima Indonesia. Kegiatan dengan tema pendampingan pengisian dan pelaporan SPT Tahunan orang pribadi dan sosialisasi pemadanan NIK-NPWP dapat digunakan sebagai sarana membina para dosen dalam meningkatkan daya saing, kemampuan, keterampilan, kemadirian dalam pelaksanaan pengabdian kepada masyarakat. Hasil dari kegiatan yang dilakukan mendapatkan respon yang baik dan peserta mendapatkan manfaat yaitu dapat menyelesaikan proses pelaporan SPT Tahunan atas kewajibannya dalam perpajakan. Kegiatan ini juga bermanfaat membantu pemerintah dalam sosialisasi pemadanan NIK-NPWP dilingkungan PMKM Prima Indonesia.
TINGKAT SERANGAN PENYAKIT BUSUK BUAH KAKAO (Phytophthora palmivora L.) DAN KEHILANGAN HASIL TANAMAN KAKAO DI KECAMATAN DARUL IHSAN KABUPATEN ACEH TIMUR
Authors: Muhammad Fajar Zikri  , Cut Mulyani  , Yenni Marnita
Published: August 2023

Indonesia merupakan salah satu satu negara pembudidaya tanaman kakao paling luas di dunia dan termasuk negara penghasil kakao terbesar ketiga setelah Pantai Gading  dan Ghana, yakni dengan nilai produksi tahunannya 593.331 ton dimana 94,78% hasil produksi kakao Indonesia berasal dari perkebunan rakyat. Sebagian besar perkebunan kakao di kabupaten Aceh merupakan perkebunan rakyat. Salah satu wilayah penghasil kakao di Aceh yaitu Kabupaten Aceh Timur di Kecamatan Darul Ihsan. Terdapat lima desa penghasil kakao di kecamatan Darul Ihsan yaitu, Lhok Leumak, Seuneubok Teungoh, Lhok Meureu, Panton Meureubo dan Seuneubok Kulam. Rendahnya produktivitas tanaman kakao merupakan masalah klasik yang hingga kini masih sering di hadapi. Selain penyaki busuk buah kakao, serangan Vascular Streak Dieback/VSD yang disebabkan oleh jamur Oncobasidium theobromae dan Penggerek Buah Kakao (PBK) yang disebabkan hama Conophomorpha cramenella juga menjadi masalah utama di beberapa daerah produksi kakao. Tujuan penelitian ini adalah mengetahui persentase dan intensitas serangan busuk buah kakao di Kecamatan Darul Ihsan Kabupaten Aceh Timur serta mengetahui tingkat kehilangan hasil akibat serangan penyakit busuk buah kakao di Kecamatan Darul Ihsan Kabupaten Aceh Timur. Penelitian ini menggunakan metode survey dengan teknik observasi dengan pengambilan contoh (sampling) pada tanaman yang memiliki kriteria yang akan diamati. Hasil pengamatan yang diperoleh menunjukkan bahwa persentase dan intensitas serangan penyakit busuk buah kakao P. palmivora tertinggi yaitu pada kebun dengan kriteria tidak terawat dengan nilai 71,21% dan 32,27% yaitu pada Desa Lhok Meureu. Persentase dan intensitas serangan penyakit busuk buah kakao P. palmivora yang terendah terdapat pada kriteria kebun terawat dengan nilai masing-masing 36,79% dan 11,64% yaitu pada Desa Lhok Leumak. Kehilangan hasil akibat meningkatnya intensitas serangan penyakit busuk buah kakao P. palmivora di Kecamatan Darul Ihsan mencapai 481,78 Kg/Ha/tahun dengan intensitas serangan rata-rata 24,77%. Tingginya persentase serangan dan intensitas serangan penyakit ini diantaranya dikarenakancara budidaya yang tidak tepat, sanitasi lingkungan yang buruk, tidak adanya perawatan lahan pertanaman, curah hujan dan kelembaban yang tinggi.

Kata kunci:Tanaman kakao, P. palmivora, penyakit busuk buah
UJI ADAPTASI BEBERAPA VARIETAS PADI LOKAL ACEH DAN DOSIS PUPUK NPK-PIM DAN PUPUK POLIVIT-PIM TERHADAP PRODUKSI TANAMAN PADI (Oryza sativa L.)
Authors: Maulida  , Iswahyudi  , Yenni Marnita
Published: August 2023

Penelitian ini bertujuan untuk mengetahui adaptasi beberapa varietas padi lokal aceh dan dosis pupuk NPK-PIM dan Polivit-PIM terhadap produksi tanaman padi, serta interaksi kedua perlakuan tersebut. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) pola faktorial  yang  terdiri dari 2 taraf yaitu: faktor varietas padi (V) terdiri dari 5 jenis: V1= Inpari 32 (kontrol), V2= US-02 Batuta, V3= Galur Gaptas, V4= UA-12 Sigupai, V5= UA-11. Faktor dosis pupuk (P) terdiri dari 4 taraf: P0= 0 kg ha-1 (kontrol ), P1= 100 kg ha-1 NPK PIM 15-15-15 + 200 kg ha-1 Polivit PIM, P2= 150 kg ha-1 NPK PIM 15-15-15 + 150 kg ha-1 Polivit PIM, P3= 200 kg ha-1 NPK PIM 15-15-15 + 100 kg ha-1 Polivit PIM. Parameter yang diamati dalam penelitian ini meliputi jumlah gabah per malai (butir), bobot 1.000 butir gabah (gr), persen gabah berisi (%), persen gabah hampa (%), hasil gabah ubinan (kg), dan dugaan hasil gabah per hektar (ton). Hasil penelitian menunjukkan bahwa varietas padi berpengaruh sangat nyata terhadap semua parameter yang diambil. Produksi tertinggi diperoleh pada varietas US-02 Batuta (V2). Adapun kombinasi dosis pupuk berpengaruh sangat nyata terhadap parameter jumlah gabah per malai, persentase gabah berisi dan persentase gabah hampa, berpengaruh nyata terhadap parameter hasil gabah ubinan dan dugaan hasil gabah per hektar, serta berpengaruh tidak nyata terhadap bobot 1.000 butir gabah. Perlakuan terbaik diperoleh pada perlakuan kombinasi dosis pupuk 150 kg ha-1 NPK PIM 15-15-15 + 150 kg ha-1 Polivit PIM (P2). Interaksi antara faktor varietas padi dengan faktor kombinasi dosis pupuk berpengaruh sangat nyata terhadap jumlah gabah per malai, persentase gabah berisi, persentase gabah hampa, hasil gabah ubinan dan dugaan hasil gabah per hektar. Namun berpengaruh tidak nyata terhadap bobot 1.000 butir gabah. Interaksi terbaik diperoleh pada kombinasi perlakuan varietas US-02 Batuta dengan dosis pupuk 150 kg ha-1 NPK PIM 15-15-15 + 150 kg ha-1 Polivit PIM (V2P2).

Kata Kunci : Padi Lokal, Dosis Pupuk, Produksi.
Cuidado culturalmente competente: puntos de vista de enfermería de salud pública e indígena
Authors: López-Díaz Lucero , Orozco Castillo Liliana
Published: August 2023

Introducción. Existe la necesidad de obtener el sentir del receptor de cuidado de enfermería culturalmente competente, sin expresar la necesidad de obtener el sentir de la Enfermera. Se interpretaron los puntos de vista de la enfermera de salud pública y del indígena embera chamí en Riosucio, Caldas (Colombia), frente al cuidado realizado y recibido en un acto culturalmente competente. Metodología. Etnografía interpretativa con observación participante y entrevistas a profundidad participaron tres enfermeras y once indígenas. Se analizaron los datos con la propuesta de Leininger. Resultados. El patrón cultural consta de tres categorías, demostrando satisfacción entre los puntos de vista de la enfermera y del indígena frente al cuidado ofrecido y recibido. Se destaca un diálogo de saberes y profesionales con capacidades para ofrecer cuidado culturalmente competente. Conclusión. Conocer la perspectiva tanto del proveedor como receptor del cuidado permite mejorar los efectos del cuidado culturalmente competente en salud pública.
BCL3 rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases
Authors: Carbo-Meix Anna , Guijarro Francesca , Wang Luojun , Grau Marta , Royo Romina , Frigola Gerard , Playa-Albinyana Heribert , Buhler Marco M. , Clot Guillem , Duran-Ferrer Marti , Lu Junyan , Granada Isabel , Baptista Maria-Joao , Navarro Jose-Tomas , Espinet Blanca , Puiggros Anna , Tapia Gustavo , Bandiera Laura , De Canal Gabriella , Bonoldi Emanuela , Climent Fina , Ribera-Cortada Inmaculada , Fernandez-Caballero Mariana , De la Banda Esmeralda , Do Nascimento Janilson , Pineda Alberto , Vela Dolors , Rozman Maria , Aymerich Marta , Syrykh Charlotte , Brousset Pierre , Perera Miguel , Yanez Lucrecia , Ortin Jesus Xavier , Tuset Esperanza , Zenz Thorsten , Cook James R. , Swerdlow Steven H. , Martin-Subero Jose I. , Colomer Dolors , Matutes Estella , Bea Silvia , Costa Dolors , Nadeu Ferran , Campo Elias
Published: August 2023

The t(14;19)(q32;q13) often juxtaposes BCL3 with immunoglobulin heavy chain (IGH) resulting in overexpression of the gene. In contrast to other oncogenic translocations, BCL3 rearrangement (BCL3-R) has been associated with a broad spectrum of lymphoid neoplasms. Here we report an integrative whole-genome sequence, transcriptomic, and DNA methylation analysis of 13 lymphoid neoplasms with BCL3-R. The resolution of the breakpoints at single base-pair revealed that they occur in two clusters at 5’ (n=9) and 3’ (n=4) regions of BCL3 associated with two different biological and clinical entities. Both breakpoints were mediated by aberrant class switch recombination of the IGH locus. However, the 5’ breakpoints (upstream) juxtaposed BCL3 next to an IGH enhancer leading to overexpression of the gene whereas the 3’ breakpoints (downstream) positioned BCL3 outside the influence of the IGH and were not associated with its expression. Upstream BCL3-R tumors had unmutated IGHV, trisomy 12, and mutated genes frequently seen in chronic lymphocytic leukemia (CLL) but had an atypical CLL morphology, immunophenotype, DNA methylome, and expression profile that differ from conventional CLL. In contrast, downstream BCL3-R neoplasms were atypical splenic or nodal marginal zone lymphomas (MZL) with mutated IGHV, complex karyotypes and mutated genes typical of MZL. Two of the latter four tumors transformed to a large B-cell lymphoma. We designed a novel fluorescence in situ hybridization assay that recognizes the two different breakpoints and validated these findings in 17 independent tumors. Overall, upstream or downstream breakpoints of BCL3-R are mainly associated with two subtypes of lymphoid neoplasms with different (epi)genomic, expression, and clinicopathological features resembling atypical CLL and MZL, respectively.
The role of biodiversity in adaptation to climate change: a review
Authors: Gizachew Girma
Published: August 2023

Biodiversity and well-functioning ecosystems provide natural solutions that foster resilience, thereby assisting society in adapting to the negative effects of climate change. Through conducting a thorough review on maintaining and restoring native ecosystems, agrobiodiversity, landscape connectivity, and protected areas, this project aims to achieve its objective. Biodiversity is the variety of all living organisms on the planet. To examine the role of biodiversity in climate change adaptation, 55 distinct sources, including 50 peer-reviewed publications and 5 books, were utilized. The current analysis identifies sustainable management of biodiversity as an essential climate change adaptation strategy because species and genetically diverse ecosystems have a greater capacity to adjust to climate change. Furthermore, such measures boost the climate change resilience of ecosystems. So that they can continue to provide ecosystem services, hence facilitating the supply of alternate means of subsistence in the face of climate change. Many of these studies assume that biodiversity and climate change are tightly interconnected due to their mutual impacts. For instance, human-induced climate change poses a threat to biodiversity, but biodiversity resources can mitigate the effects of climate change on populations and ecosystems. However, a large number of research also point to context-dependent adaptation techniques that can be either positive or harmful depending on the circumstances. The majority of research has been undertaken on the poorest or most vulnerable households, with a primary focus on small islands and mountains, whereas other ecosystem products have been mostly neglected. Consequently, an essential strategy for conserving biodiversity and human well-being entails measures that are kept flexible in order to better adapt human societies to climate change, as well as biodiversity education and training activities that are superior at distributing innovative techniques.
Farmers perception on pest management practices and profitability analysis for five winter vegetable production
Authors: Chanda Sontosh Chandra , Khan Md Johny , Sarkar Subhash Chandra , Sarwar A K M Golam
Published: August 2023

The purpose of the study was to determine the farmers' perceptions of management measures against insect and disease pests and the profitability of five winter vegetables grown in Bangladesh's Sirajganj area. The highest incidences of fungal infections, including curd rot of cauliflower and early blight of tomato, were discovered. One of the most destructive diseases of brinjal and tomato was wilt, which was caused by both fungi and bacteria. Farmers took the necessary steps to control aphids (40-150 insects m–2 or 20-50 infected shoots m–2), brinjal shoot and fruit borer (10-50 insects 10m–2 or 20-60 infected shoots or fruits 10m–2), and other insects at the threshold level. They employed physical, chemical, and Integrated Pest Management (IPM) techniques to manage the disease and insect pests. The greatest amount of insecticide spraying (35-45 times) was performed to control brinjal shoot and fruit borer insects. The entire manufacturing cost followed the pattern tomato > brinjal > bean > cauliflower > bottle gourd. The cultivation of brinjal yielded the highest return, gross margin, and net return (Tk. 987,000.00, Tk. 800,572.00, and Tk. 763,117.00 ha–1, respectively; US$ 1 = Bangladesh currency Tk. In contrast, bottle gourd farming yielded the lowest return (Tk 700,000.00 ha–1), and tomato cultivation yielded the lowest gross margin and net return (Tk 539,152.00 and 507,325.00, respectively). The brinjal cultivation had the highest profitability index, benefit-cost ratio (both variable and total cost basis), and rate of return on investment, whereas tomato cultivation had the lowest. Rot, blight disease, shoot and fruit borer, or fruit borer, and aphid were the most common pests of winter vegetables in the region surveyed. Finally, we discovered that brinjal is the most profitable vegetable in our area of study.
Performance Evaluation of Code Division Multiple Access (CDMA) in terms of Power Measurement and Reduction
Authors: Hasan Syed Rizwan-ul- , Ahmed Shakil
Published: August 2023

In this research paper the performance of the CDMA system has been analyzed with respect to PAPR (Peak to Average Power Ratio) measurement and its reduction. Simulation results verify that high peaks degrade the performance of CDMA, application of codes reduced high peaks and PAPR is a good measure for CDMA.
Performance Assessment of High Availability Clustered Computing using LVS-NAT
Authors: Shaikh Muhammad Kashif , Khan Muzammil Ahmad , Imam Mumtaz -ul-
Published: August 2023

High availability cluster computing environment attempts to provide high availability to computing services. This paper evaluates building and investigating a highly available computing environment that provides a solution to achieve high availability. A prototype of cluster computing environment is developed in Linux environment to provide a single but highly available point of entry. The cluster of computers run web based application to provide services to HTTP users.
Особенности механизмов действия ингибирующих и флегматизирующих огнетушащих составов
Authors: Журов Марк Михайлович
Published: August 2023

Цель. Проанализировать теоретические аспекты механизмов действия ингибирующих и флегматизирующих огнетушащих составов.
Методы. Аналитический, сравнительная оценка механизмов действия ингибирующих и флегматизирующих составов.
Результаты. Сопоставительный анализ теоретических аспектов механизмов действия ингибирующих и флегматизирующих составов. Показана энергетическая взаимосвязь химической реакции горения с тепловой теорией потухания. Обобщены значения энергий разрыва связей для некоторых горючих молекул и их радикалов. Сопоставлены стандартные энергии разрыва химических связей галогенпроизводных предельных углеводородов и их огнетушащая эффективность, что свидетельствует о взаимосвязи их природы с огнетушащим действием.
Область применения исследований. Современные подходы к разработке огнетушащих составов целевого назначения. Разработка инновационных материалов и технологий.
Short-term Efficacy and Safety of Intravitreal Brolucizumab Injection for Treatment-Naive Exudate Age-related Macular Degeneration: A Multicenter Study
Authors: Kim Juno , Lee Sung Jin , Park Tae Kwann , Sun Hae Jung , Kim Hoon Dong , Cho In Hwan , Han Jung Woo , Choi Kyung Seek
Published: August 2023

Purpose: To compare short-term efficacy and safety of intravitreal brolucizumab injection with aflibercept in treatment-naive neovascular age-related macular degeneration (nAMD) patients.Methods: A total of 59 eyes from 59 treatment-naive nAMD patients in three hospitals were retrospectively reviewed. Of which, 27 patients underwent intravitreal brolucizumab injections and 32 received aflibercept. After monthly consecutive three injections, best-corrected visual acuity (BCVA; in logarithm of minimal angle of resolution [logMAR]), central macular thickness (CMT), dry macula achievement rate, and intraocular inflammation (IOI) incidence were compared.Results: After loading-phase treatment, BCVA was significantly increased from 0.48 ± 0.30 logMAR at baseline to 0.33 ± 0.21 logMAR at 3 months in the brolucizumab group (p = 0.002) and 0.40 ± 0.39 logMAR at baseline to 0.33 ± 0.36 logMAR at 3 months in the aflibercept group (p = 0.007). But there was no significant difference in BCVA improvement at 3 months between the two groups. CMT significantly decreased from 429.67 ± 250.59 μm at baseline to 210.67 ± 93.53 μm at 3 months in the brolucizumab group and from 346.69 ± 159.09 μm to 234.52 ± 83.42 μm in the aflibercept group (both p < 0.001). The amount of CMT reduction was significantly greater in the brolucizumab group after 3 months (p = 0.036). In typical AMD eyes, brolucizumab showed similar BCVA improvement but better CMT reduction at 3 months (p = 0.018). Dry macula achievement rate was not significantly different between the two groups. One IOI was observed in the brolucizumab group.Conclusions: Intravitreal injections of brolucizumab and aflibercept showed similar anatomical and functional outcomes. But CMT reduction was greater in the brolucizumab group. One IOI was identified, which was tolerable for topical agents. These results suggest that brolucizumab could be a novel first line treatment option for treating naive nAMD patients.
Pengembangan Aktivitas Pembelajaran Menggunakan Mathcitymap dalam Kemampuan Pemecahan Masalah Berbasis Etnomatematika Konteks Benteng Vredeburg Yogyakarta
Authors: Gabriela Alvina Maheswari  , Endah Saraswati  , Marcellinus Andy Rudhito
Published: August 2023

Teknologi yang ada di Indonesia semakin berkembang pada abad 21 ini. MathCityMap merupakan salah satu perkembangan teknologi yang dapat membantu peserta didik dalam pembelajaran matematika. Kemampuan pemecahan masalah merupakan salah satu masalah yang ada di pembelajaran matematika. Peningkatan kemampuan pemecahan masalah siswa dengan konteks pembelajaran menggunakan MathCityMap berbasis Etnomatematika. Konteks yang diangkat pada penelitian ini adalah penggunaan MathCityMap berbasis Etnomatematika pada Benteng Vredeburg Yogyakarta. Benteng Vredeburg ini merupakan wisata yang tengah digandrungi oleh anak muda karena situasi yang ada di benteng Vredeburg Yogyakarta yang bergaya vintage dapat digunakan swafoto atau pemotretan untuk kegiatan tertentu. Penelitian ini merupakan penelitian pengembangan atau biasa disebut Research and Development (R&D). Metode yang digunakan dalam penelitian ini adalah ADDIE. Metode ADDIE terdiri dari 5 tahap yaitu Analysis, Design, Development, İmplementation, dan Evaluation. Tujuan penelitian ini adalah mengembangkan media pembelajaran dengan menggunakan MathCityMap bagi peserta didik tingkat SMP.  Hasil dari penelitian ini adalah pengembangan MathCityMap dengan menggunakan konteks benteng Vredeburg yang telah diuji coba oleh teman sejawat dengan rata-rata hasil penilaian  adalah 4,56 dari 5 termasuk dalam kategori sangat baik. Oleh karena itu, MathCityMap yang dikembangkan oleh peneliti dapat digunakan dalam pembelajaran matematika.
Analisis Kemampuan Berpikir Kritis Matematis dalam Menyelesaikan Masalah Barisan dan Deret Ditinjau dari Disposisi Berpikir Kritis
Authors: Rizqiyah Aghniya Barkah , Aripin  , Lestari Puji
Published: August 2023

Penelitian ini bertujuan untuk mendeskripsikan kemampuan berpikir kritis matematis siswa dalam menyelesaikan masalah barisan dan deret ditinjau dari disposisi berpikir kritis. Jenis penelitian ini adalah deskriptif kualitatif. Subjek dalam penelitian ini sebanyak 9 siswa kelas XI IPA SMA IT Ibadurrohman, Kota Tasikmalaya, Jawa Barat yang terdiri dari 3 siswa dengan disposisi berpikir kritis tinggi, 3 siswa dengan disposisi berpikir kritis sedang dan 3 siswa dengan disposisi berpikir kritis rendah. Pengumpulan data melalui tes kemampuan berpikir kritis materi barisan dan deret, dan angket disposisi berpikir kritis yang sudah tervalidasi serta wawancara tidak terstruktur. Teknik analisis data pada penelitian ini yaitu reduksi data, penyajian data dan pengambilan kesimpulan. Hasil dari penelitian ini adalah 1) Subjek penelitian dengan level disposisi berpikir kritis tinggi (DBKT) memiliki kemampuan berpikir kritis yang baik ditunjukkan dengan penguasaan keenam indikator kemampuan berpikir kritis matematis.  2) Subjek penelitian dengan level disposisi berpikir kritis sedang (DBKS) memiliki kemampuan berpikir kritis yang beragam, DBKS1 hanya memenuhi 5 indikator dari 6 indikator kemampuan berpikir kritis matematis, 2 diantaranya dilalui dengan lengkap dan 3 lainnya kurang tepat, DBKS2 memenuhi keenam indikator kemampuan berpikir kritis matematis, dan DBKS3 hanya memenuhi 2 indikator kemampuan berpikir kritis matematis. 3) Subjek penelitian dengan level disposisi berpikir kritis rendah (DBKR) pada umumnya memenuhi 5 indikator kemampuan berpikir kritis dan tidak memenuhi indikator mengevaluasi hasil penyelesaian masalah secara keseleruhan (overview).
TREN PENELITIAN REPOSITORI INSTITUSI DI ERA DIGITAL: ANALISIS BIBLIOMETRIK BERBASIS DATA SCOPUS
Authors: Tupan Tupan
Published: August 2023

Analyzed trends in institutional repository research in the digital era. The purpose of this study is to find out: (a) trends in the publication of research results from institutional repositories by year; (b) the most productive core journal publishes the results of institutional repository research; (c) distribution of language repository publications; (d) state-based institutional repository research distribution; (e) the most productive institutions publish institutional research repositories; (f) the most productive researchers publish research on institutional repositories; (g) the highest frequency of occurrence of keywords. Research uses bibliometric methods. The results showed that the trend of the distribution of research on institutional reposotions indexed at the peak of Scopus occurred in 2014, namely 84 publications (13.15%). Of the 21 highest journals that published the results of the institutional repository research, it was shown that Lecture Notes in Computer Science were the most published public institution repositories, namely 23 publications (3.6%), followed by the Electronic Library with 18 publications (2.8%), and D Lib Magazine 16 publications (2.5%). Publication of the results of research on institutional repositories indexed in Scopus data base was published in twelve languages and most of them were English. The institutional research repository trend indexed in Scopus is mostly in the form of articles and published by the United States of America. Abrizah, A. From the University of Malaya, Kuala Lumpur, Malaysia is the most productive researcher and has published the results of 6 institutional repository studies and has been cited 614 times. The mapping results using vosviewer software show that the trend of institutional repository research is divided into 7 clusters with the most occurrence of keywords being Institutional Repositories, then Institutional Repositories, Digital Libraries and Open Access.From the results of the institutional repository research trends that have been conducted can be used for the development of further research.
THE CHALLENGES AND BENEFITS OF KNOWLEDGE MANAGEMENT SYSTEM TO LIBRARIAN COMPETENCIES AND SKILLS: A SYSTEMATIC LITERATURE REVIEW
Authors: Aryanto Febri , Prima Pudy , Lusa Jonathan Sofian
Published: August 2023

Knowledge Management is relatively new to libraries, hence it is important to find its impact and implications for libraries and LIS professionals. The objective of this paper is to summarize the existing researches concerning the challenges and benefits as implications of knowledge management system in libraries. Through a systematic literature review method, this paper wants to research knowledge management system related to librarian competencies and skills from challenges and benefits point of view. The results showed that the librarian should prepare to face for the challenges of KM to get benefits by utilized the KMS so that they can increase their competencies and skills in the future.
RANCANG BANGUN SISTEM PEMBANGKIT LISTRIK TENAGA SURYA TERHUBUNG DENGAN JARINGAN LISTRIK PLN PADA KANTOR DI BINTARO - JAKARTA SELATAN
Authors: Brilliant Brilliant , Purba Robinson , Soebagio Atmonobudi
Published: August 2023

This paper discusses the design and construction of a solar powered generation system (PVs) in a 3-storey office building in the Bintaro area. The paper discusses  the costs  to build PVs, as well as an analysis of the value of investments using RETScreen Expert software. The calculation to get the PVs capacity is based on the area of ​​the roof and the electricity load of the office. This PV system will be integrated with the PLN electricity network in serving electricity loads in offices on each floor. The type of PV module has 305Wp capacity per module. The investment value is simulated with the assumption that  battery units are replacemed every 3 years, repayment of the loan for 10 years with an advance of 50%, an interest rate of 5.75% and inflation of 3.28%. From the simulation we also obtained a comparison of investments between replacing the battery units once every 3 years with every 10 years, which became the basis for the decision of the PLTS owner to determine the scheme to be choiced.
Analisis Perencanaan dan Kajian Ekonomi dalam Penggunaan PV Menuju Low Energy Building Pada Hote Inaya Putri Bali
Authors: Mugni Fendy Eventius , Widodo Bambang , Stepanus Stepanus
Published: August 2023

Industrial and business growth develops rapidly from time to time. This also encourages higher energy use and energy use is a major contributor to operational costs. This study aims to carry out planning and economic studies in the use of PV towards a low-energy building at Hote Inaya Putri Bali. The method used in this research is the survey method and literature study. Primary data is obtained from the 2019 Electricity Bill. The data is then used to calculate the Intensity of Energy Consumption, then taken from energy simulations using solar solar with Homer software simulations. The results showed that the IKE in the Inaya Putri Bali Hotel building was 131.8 kWh / m2 / year, meaning that energy use in the Inaya Putri Bali Hotel building was still efficient. Using the solar cell simulation results, the energy obtained is 443,732 kWh per year at a cost of Rp. 972 / kWh, which means energy savings of Rp. 35,942,292 per month or 14.5% per year.
Korkuyu Politikleştirmek, Öfkeyi Örgütlemek: Fransa’da (Reconquête) ve Türkiye’de (Zafer Partisi) Aşırı Sağ
Authors: Koca Bayram , Saç Selman
Published: August 2023

Bir süredir özellikle Avrupa’nın gündemini meşgul eden göçmen-mülteci meselesi Suriye Savaşı’ndan sonra daha geniş bir coğrafyanın sorunu haline geldi. Bu durumun, ilk elden sonucu dışlayıcı politik bir dil üzerinden (yabancı düşmanı) gücünü konsolide eden politik aktörlerin toplumsal ve siyasi etkilerini arttırmış olmalarıdır. Bu bağlamda göçmen karşıtlığını temel mesele haline getiren aşırı sağ aktörlerin daha fazla görünür olduğu, seslerini daha gür çıkarttığı ve iktidar politikalarını etkilemeye başladıkları bir konjonktürden bahsedilebilir. Uzun bir süredir aşırı sağ aktörlere ev sahipliği yapan Fransa ve ülkedeki yabancıların (mültecilerin) ilk kez politik bir meseleye dönüşmeye başladığı Türkiye, bu çerçevede önemli iki ülke konumundadır. Bu çalışmada Reconquête ve Zafer Partisi, özellikle göçmen meselesine yaklaşımları üzerinden karşılaştırmalı olarak tartışılacaktır. Bu çalışma, aralarındaki bazı farklılıklara rağmen, Reconquête ve Zafer Partisi’nin Fransa ve Türkiye’deki ekonomik, toplumsal ve siyasal birçok sorunun kaynağı olarak göçmenleri gördüğünün ve böylece onları “günah keçisi” haline getirdiğinin altını çizmektedir.
Survey of topical exposure concerns for patients and caregivers dealing with atopic dermatitis
Authors: Ratley Grace , Sun Ashleigh A. , Capozza Korey , Barta Kelly , Myles Ian A.
Published: August 2023

Background

Despite the recent expansion of treatment options in atopic dermatitis (AD), most management responsibilities fall on the patient and/or caregivers. Disease control often requires vigilance about and avoidance of common exposures, however the concerns for patients and caregivers living with AD have not been well enumerated.

Methods

An IRB approved survey was distributed to the public to evaluate the patient and caregiver concerns for topical exposures and potential triggers.

Results

323 people accessed the link to the survey with 259 providing response to at least one section of questions (response rate 80.2%). Results indicated that temperature and other weather related changes were the most common trigger. Nearly all respondents avoided at least one topical ingredient, with fragrances being the most common. Steroid exposure was common, however respondents expressed concerns about overall steroid exposure.

Conclusions

Our results attempt to enumerate the daily topical exposure concerns for patients and caregivers living with AD. While our online survey is both limited and without mechanistic insights, our results provide insight to providers by highlighting the role of temperature in AD symptoms; identifying commonly perceived triggers; indicating the value of provider insight for topical product selection; and indicating that no specific aspect of topical corticosteroid exposure may alleviate the general steroid concerns for patients or caregivers.
BMP-2 releasing mineral-coated microparticle-integrated hydrogel system for enhanced bone regeneration
Authors: Xu Hongwei , Luo Huanhuan , Chen Jiayu , Chen Gang , Yu Xiaohua , Ye Zhaoming
Published: August 2023

Introduction: Large bone defects (LBD) caused by trauma, infection, and tumor resection remain a significant clinical challenge. Although therapeutic agents such as bone morphogenetic protein-2 (BMP-2), have shown substantial potency in various clinical scenarios, their uncontrollable release kinetics has raised considerable concern from the clinical viewpoint. Mineral-coated microparticle (MCM) has shown its excellent biologics loading and delivery potential due to its superior protein-binding capacity and controllable degradation behaviors; thus, it is conceivable that MCM can be combined with hydrogel systems to enable optimized BMP-2 delivery for LBD healing.

Methods: Herein, BMP-2 was immobilized on MCMs via electrostatic interaction between its side chains with the coating surface. Subsequently, MCM@BMP-2 is anchored into a hydrogel by the crosslinking of chitosan (CS) and polyethylene glycol (PEG).

Results and Discussion: This microparticle–hydrogel system exhibits good biocompatibility, excellent vascularization, and the sustained release of BMP-2 in the bone defect. Furthermore, it is observed that this microsphere–hydrogel system accelerates bone formation by promoting the expression of osteogenesis-related proteins such as RUNX2, osteopontin, and osteocalcin in bone marrow mesenchymal stem cells (BMSCs). Thus, this newly developed multifunctional microparticle–hydrogel system with vascularization, osteogenesis, and sustained release of growth factor demonstrates an effective therapeutic strategy toward LBD.
Highly sensitive detection of CYFRA21-1 with a SERS sensing platform based on the MBs enrichment strategy and antibody-DNA-mediated CHA amplification
Authors: Bao Xiaotao , Wang Shiyi , Liu Xiaoyan , Li Guang
Published: August 2023

Laryngeal carcinoma (LC) is the second most common malignant tumor of the head and neck. Due to its insidious nature, most patients have developed to the middle and late stages by the time they are diagnosed, missing the best treatment period. Thus, early detection, diagnosis and treatment are crucial to improve the prognosis of LC and enhance the quality of life of patients. In this study, a surface-enhanced Raman (SERS) sensing platform was developed by combining the magnetic beads (MBs) enrichment strategy and the antibody-DNA-mediated catalytic hairpin self-assembly (CHA) signal amplification technology. 4-Mercaptobenzoic acid (4-MBA) and hairpin DNA 1 (hpDNA1) were modified onto the surface of gold nanobipyramids (GNBPs) as SERS nanotags. Hairpin DNA 2 (hpDNA2) modified MBs were used as capture nanoprobes. Under the action of CHA and magnet-induced MBs enrichment, GNBPs can be assembled on the surface of MBs, forming high-density “hot spots” for the SERS signal enhancement. The results showed that the SERS sensing platform has the advantages of high sensitivity, high specificity and high reproducibility, with the limit of detection (LOD) low to pg/mL level. The expression level of CYFRA21-1 in serum of LC patients and healthy controls was successfully detected by the SERS sensing platform. The accuracy of the SERS results was verified by enzyme linked immunosorbent assay (ELISA). Therefore, this SERS sensor can be used for the detection of CYFRA21-1 in serum, providing a simple and reliable new method for the early diagnosis of LC.
Age-dependent structural reorganization of utricular ribbon synapses
Authors: Michanski Susann , Henneck Timo , Mukhopadhyay Mohona , Steyer Anna M. , Gonzalez Paola Agüi , Grewe Katharina , Ilgen Peter , Gültas Mehmet , Fornasiero Eugenio F. , Jakobs Stefan , Möbius Wiebke , Vogl Christian , Pangršič Tina , Rizzoli Silvio O. , Wichmann Carolin
Published: August 2023

In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the vestibular labyrinth. Vestibular hair cells (VHCs) harbor synaptic ribbons at their presynaptic active zones (AZs), which play a critical role in molecular scaffolding and facilitate synaptic release and vesicular replenishment. With advancing age, the prevalence of vestibular deficits increases; yet, the underlying mechanisms are not well understood and the possible accompanying morphological changes in the VHC synapses have not yet been systematically examined. We investigated the effects of maturation and aging on the ultrastructure of the ribbon-type AZs in murine utricles using various electron microscopic techniques and combined them with confocal and super-resolution light microscopy as well as metabolic imaging up to 1 year of age. In older animals, we detected predominantly in type I VHCs the formation of floating ribbon clusters, mostly consisting of newly synthesized ribbon material. Our findings suggest that VHC ribbon-type AZs undergo dramatic structural alterations upon aging.
Co-occurrence of Beckwith-Wiedemann syndrome and pseudohypoparathyroidism type 1B: coincidence or common molecular mechanism?
Authors: Pignata Laura , Cecere Francesco , Acquaviva Fabio , D’Angelo Emilia , Cioffi Daniela , Pellino Valeria , Palumbo Orazio , Palumbo Pietro , Carella Massimo , Sparago Angela , De Brasi Daniele , Cerrato Flavia , Riccio Andrea
Published: August 2023

Imprinting disorders are congenital diseases caused by dysregulation of genomic imprinting, affecting growth, neurocognitive development, metabolism and cancer predisposition. Overlapping clinical features are often observed among this group of diseases. In rare cases, two fully expressed imprinting disorders may coexist in the same patient. A dozen cases of this type have been reported so far. Most of them are represented by individuals affected by Beckwith–Wiedemann spectrum (BWSp) and Transient Neonatal Diabetes Mellitus (TNDM) or BWSp and Pseudo-hypoparathyroidism type 1B (PHP1B). All these patients displayed Multilocus imprinting disturbances (MLID). Here, we report the first case of co-occurrence of BWS and PHP1B in the same individual in absence of MLID. Genome-wide methylation and SNP-array analyses demonstrated loss of methylation of the KCNQ1OT1:TSS-DMR on chromosome 11p15.5 as molecular cause of BWSp, and upd(20)pat as cause of PHP1B. The absence of MLID and the heterodisomy of chromosome 20 suggests that BWSp and PHP1B arose through distinct and independent mechanism in our patient. However, we cannot exclude that the rare combination of the epigenetic defect on chromosome 11 and the UPD on chromosome 20 may originate from a common so far undetermined predisposing molecular lesion. A better comprehension of the molecular mechanisms underlying the co-occurrence of two imprinting disorders will improve genetic counselling and estimate of familial recurrence risk of these rare cases. Furthermore, our study also supports the importance of multilocus molecular testing for revealing MLID as well as complex cases of imprinting disorders.
Severe problem of macrolides resistance to common pathogens in China
Authors: Li Jialin , Liu Lesen , Zhang Hua , Guo Jing , Wei Xiaoling , Xue Min , Ma Xiang
Published: August 2023

With the widespread use of macrolide antibiotics in China, common pathogens causing children’s infections, such as Streptococcus pneumoniae, Streptococcus (including Group A streptococcus, Group B streptococcus), Staphylococcus aureus, Bordetella pertussis, and Mycoplasma pneumoniae, have shown varying degrees of drug resistance. In order to provide such problem and related evidence for rational use of antibiotics in clinic, we reviewed the drug resistance of common bacteria to macrolides in children recent 20 years.