bluuebunny/crossref_metadata_2025 huggingface dataset:
An investigation of feed-forward and feed-back eye movement training in immersive virtual reality
Authors: Harris David , Wilson Mark , Jones Martin I. , de Burgh Toby , Mundy Daisy , Arthur Tom , Olonilua Mayowa , Vine Samuel James
Published: September 2022

The control of eye gaze is critical to the execution of many skills. The observation that task experts in many domains exhibit more efficient control of eye gaze than novices has led to the development of gaze training interventions that teach these behaviours. We aimed to extend this literature by i) examining the relative benefits of feed-forward (observing an expert’s eye movements) versus feed-back (observing your own eye movements) training, and ii) automating this training within virtual reality. Serving personnel from the British Army and Royal Navy were randomised to either feed-forward or feed-back training within a virtual reality simulation of a room search and clearance task. Eye movement metrics – including visual search, saccade direction, and entropy – were recorded to quantify the efficiency of visual search behaviours. Feed-forward and feed-back eye movement training produced distinct learning benefits, but both accelerated the development of efficient gaze behaviours. However, we found no evidence that these more efficient search behaviours transferred to better decision making in the room clearance task. Our results suggest integrating eye movement training principles within virtual reality training simulations may be effective, but further work is needed to understand the learning mechanisms.
Bayesian Surprise Predicts Human Event Segmentation in Story Listening
Authors: Kumar Manoj , Goldstein Ariel , Michelmann Sebastian , Zacks Jeffrey M. , Hasson Uri , Norman Kenneth A
Published: September 2022

Event segmentation theory posits that people segment continuous experience into discrete events, and that event boundaries occur when there are large transient increases in prediction error. Here, we set out to test this theory in the context of story listening, by using a deep learning language model (GPT-2) to compute the predicted probability distribution of the next word, at each point in the story. For three stories, we used the probability distributions generated by GPT-2 to compute the time series of prediction error. We also asked participants to listen to these stories while marking event boundaries. We used regression models to relate the GPT-2 measures to the human segmentation data. We found that event boundaries are associated with transient increases in Bayesian surprise, but not with a simpler measure of prediction error (surprisal) that tracks, for each word in the story, how strongly that word was predicted at the previous time point. These results support the hypothesis that prediction error serves as a control mechanism governing event segmentation, and point to important differences between operational definitions of prediction error.
PENERAPAN ARSITEKTUR KONTEKSTUAL PADA BANGUNAN MASJID DI KUDUS, JAWA TENGAH
Authors: S Muhammad izhar , Prabowo Hadi , Handjajanti Sri
Published: September 2022

Pada saat ini, arsitektur kontekstual dikaitkan dengan atap lengkung serta kemegahan, seperti bentuk kubah pada masjid. Arsitektur kontekstual diterapkan dengan mengaplikasikan pada bangunan tua dengan lingkungan baru dalamnya , Setelah arsitektur ekologis menjadi acuh tak acuh dan mencoba untuk menjadi berbeda. Oleh karena itu, penting untuk memahami bagaimana arsitektur konteks mempengaruhi desain agar bangunan dapat bermanfaat dan berfungsi secara optimal. Masjid kudus memiliki desain bentuk dan tatanan ruang yang memunculkan persepsi tersendiri, baik yang melalui konsep Islam ataupun hasil dari pengamatan subjektif, menarik untuk mengkaji keterkaitan antara konsep perancangan bentuk bangunan, dan tatanan ruang luar dan dalam masjid dalam. Masjid dan data mengenai masjid yang kemudian dianalisa untuk memperoleh suatu kesimpulan bahwa masjid merupaka bangunan masjid yang dalam perencangannya mempertimbangkan nilai-nilai islam.
guia de atividades extracurriculares voltado para os estudantes do Ensino Médio Integrado do Colégio Pedro II
Authors: Ponso Fabio Cardoso , Castro Robson Costa de
Published: September 2022

O presente artigo versa sobre o processo de desenvolvimento e avaliação de um guia informativo de atividades extracurriculares voltado para a orientação dos estudantes do Ensino Médio Integrado (EMI) do Colégio Pedro II (CPII), tradicional instituição federal de ensino do Rio de Janeiro. Inspirado por aspectos teóricos, identificados na literatura acadêmico-científica e no Projeto Político Pedagógico Institucional do CPII, e por elementos empíricos, evidenciados por meio da observação direta da realidade de um dos campi da instituição, o produto educacional apresenta, ao longo de 145 páginas de textos e imagens, uma lista de todas as atividades de pesquisa e extensão ofertadas pela escola, bem como suas características específicas. O produto foi aplicado a uma amostra de educadores do EMI do CPII, que avaliaram seus potenciais impactos através de respostas a um questionário semiaberto. Os dados obtidos foram analisados de modo quanti-qualitativo, através da utilização conjunta de princípios de estatística descritiva básica e do método de análise categorial de conteúdo. Entre os principais resultados da investigação, verificou-se uma sólida percepção de que o produto se configura como um instrumento de orientação educacional e pedagógica capaz de contribuir para o empoderamento cognitivo e informacional dos estudantes do EMI, estimulando o incremento de sua participação nas atividades extracurriculares e, consequentemente, a sua inclusão e formação integral, ao encontro do objetivos político-pedagógicos do Colégio Pedro II.
Essential Oils as Alternative Halal Therapeutic Source for Lung Cancer: A Mini Review
Authors: Abdullah Nazurah , Hazahari Noor Yuslida , Amid Azura
Published: September 2022

The global Muslim population is predicted to grow significantly. The market for Halal products, an obligation for Muslims, is expanding in sync with the Muslim population. Cancer is a notable cause of death globally. Pharmaceuticals are the most important fundamental component because they are disease-specific, most notably cancer-specific. Optional pharmaceuticals were looked into to meet Muslim demand for Halal products. Some essential oils are viable therapeutic sources because they have long been used in conventional medicine for various treatments. The purpose of this study is to review the investigation done on the potential for essential oils to be used as a Halal alternative therapy for lung cancer. This mini review follows the traditional narrative review study. According to these researches, essential oils are helpful in the treatment of malignancies, notably lung cancer. However, additional research, including clinical trials, is essential to enhance the treatment's efficacy.
Prospective comprehensive evaluation of chemotherapy-induced peripheral neuropathy in patients with breast cancer
Authors:   Novosibirsk State Medical University, Pilipenko P.I. ,   Federal Research Center for Fundamental and Translational Medicine, Dobresko Yu.A. ,   Novosibirsk State Medical University; Federal Research Center for Fundamental and Translational Medicine
Published: September 2022

Introduction. Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-dependent side effect of anticancer therapy that affects the patient’s quality of life. Currently, the problem of effective and reliable diagnostics for CIPN remains unresolved. Therefore, it is critically important to develop recommendations for a comprehensive assessment of peripheral neuropathy based on simple tests for vibration, tactile, pain sensitivity together with questionnaires. Aim. A prospective comprehensive assessment of the incidence and severity of CIPN using the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) and the Patient Neurotoxicity Questionnaire (PNQ) in patients with breast cancer treated with taxanes. Materials and methods. Symptoms of CIPN were prospectively assessed in 60 patients using the PNQ, the NCI-CTCAE and the Eastern Cooperative Oncology Group (ECOG) Performance Status scores at baseline, 1 week after and 13 weeks after the start of chemotherapy. Results. The CIPN scores according to the PNQ were widely distributed among patients compared to the NCI-CTCAE scores for both sensory and motor neuropathy. There was a marked increase in symptoms of motor neuropathy in patients who were identified only on the basis of PNQ data. The PNQ was used to formally assess the impact of neuropathy on the patient’s activities of daily living. Conclusion. A comprehensive methodology based on a neurological examination together with the NCI-CTCAE and the PNQ will allow a more detailed assessment of the severity of СIPN, and in the future will provide an opportunity to develop a more effective patient management plan. The PNQ has shown itself to be a more sensitive tool compared to the NCI-STCAE, especially in assessing sensory neuropathy. Thus, it is reasonable to include patient-reported data in the evaluation of СIPN in order to provide a more accurate identification of the frequency and severity of neuropathy.
Comparison of the effectiveness of common treatment regimens for bacterial vaginosis
Authors:   Novosibirsk State Medical University, Piletskaya U.V. , Marinkin I.O. ,   Novosibirsk State Medical University, Makarov K.Yu. ,   Novosibirsk State Medical University, Sokolova T.M. ,   Novosibirsk State Medical University, Kiseleva T.V. ,   Novosibirsk State Medical University
Published: September 2022

Introduction. Bacterial vaginosis (BV), being one of the most common diseases of the female genital organs, is still of interest to a practitioner. In modern conditions, requiring a short time to make a diagnosis and start treatment, it is often necessary to prescribe treatment empirically. Given the variety of regimens for the treatment of BV, it is advisable to identify the most effective for empirical therapy. Aim. To determine the most effective treatment regimen for BV among those common in the Russian Federation. Materials and methods. The study involved 120 women aged 18 to 45 years who met the inclusion criteria: applying to the antenatal clinic with complaints of abnormal vaginal discharge, the presence of BV, confirmed by the Amsel criteria at the initial admission. The follow-up was carried out during 4 consecutive visits. At the first visit, a clinical investigation was carried out: sampling for bacterioscopic and bacteriological studies, pH-metry of the posterior vaginal vault secretion, the amine whiff test, sampling for the Femoflor 16 real-time polymerase chain reaction (RT-PCR). At the second visit, all women were divided into 4 representative groups depending on the treatment regimen (group 1: metronidazole (gel) + Lactogynal (vaginal capsules); group 2: clindamycin (cream) + Lactogynal; group 3: chlorhexidine gluconate (vaginal tablets) + Lactogynal; group 4: Elzhina (vaginal tablets) + Lactogynal). At the third visit, on the 7th day of treatment, the intermediate efficacy of the studied regimens was evaluated, and side effects were identified. The fourth visit was scheduled 10–14 days after the end of treatment, during which the final result of treatment and treatment complications were assessed. Results. There were no significant differences in the studied groups in terms of the presence of complaints of vaginal abnormal discharge, the results of bacterioscopic examination, a positive amine whiff test, and the pH level (p > 0.05). In using the Femoflor-16 RT-PCR, normal state of vaginal biocenosis was determined in 26.67% of patients of each group (p = 1.0), moderate anaerobic dysbiosis – in 33.33% (p = 1.0), severe anaerobic dysbiosis – from 33.33% (in group 4) to 40% (in groups 1–3) (p > 0.05). The most effective was the treatment regimen with the use of Elzhina, its effectiveness was 80%. Also, according to the results of the Femoflor RT-PCR, the drug Elzhina showed the highest efficacy– 96.67%. Conclusion. The most effective was the treatment regimen with the use of a combined drug with antibacterial, antiprotozoal, antifungal and anti-inflammatory action for topical administration – Elzhina. This drug is highly effective and can be recommended as an empirical treatment for BV.
Clinical phenotypes of coronary artery disease patients with intermediate coronary artery stenosis
Authors:   Novosibirsk State Medical University, Yakhontov D.A. , Ostanina Yu.O. ,   Novosibirsk State Medical University
Published: September 2022

Introduction. Patients with stable coronary artery disease (CAD) and intermediate coronary artery stenosis are of great interest because, despite the absence of obstructive coronary artery lesion, the risk of cardiovascular complications is very high and is conditioned by a number of concomitant factors. Aim. Study of cardiovascular risk factors and assessment of clinical and angiographic picture in stable CAD patients with intermediate coronary artery stenosis of various clinical phenotypes. Materials and methods. 236 stable angina pectoris class I–III patients (190 men, 46 women, age 49–59 years) with intermediate (40–70%) coronary artery stenosis were examined. All patients underwent general clinical examination, ultrasound of the heart and coronary angiography. Based on the cardio-ankle vascular index (CAVI) values, the chronological age/biological age coefficient was determined. The study design is a comparative non-randomized descriptive study of four parallel groups. Results. The prevailing phenotypes in CAD patients with intermediate (40–70%) coronary artery stenosis in a random sample turned out to be those with: CAD without a previous myocardial infarction (MI); CAD with MI > 6 months ago; CAD with metabolically unhealthy obesity (MUO) phenotype without diabetes mellitus (DM) and, finally, CAD with type 2 DM. In CAD patients with MUO and type 2 DM, the frequency of previous MI did not significantly differ. In addition, patients with CAD and MUO, who had previously had MI, differed in the earliest age of its onset. Despite the 100% presence of arterial hypertension (AH) in different phenotypes groups, CAD and type 2 DM patients had the highest values of the left ventricular mass index. They also had the most frequently recorded multivessel lesion during coronary angiography. Despite the ongoing outpatient year-long treatment, the values of lipid and inflammatory parameters (low-density lipoprotein cholesterol (LDL-C), triglycerides, C-reactive protein) were high, so, only in few patients the target values of LDL-C were reached; besides a large number of patients with insufficient blood pressure control were revealed. In more than half of the surveyed, the biological age prevailed over the chronological age. Conclusion. Stable angina patients with intermediate coronary artery stenosis represent a rather serious group in terms of prognosis. Despite the absence of vascular obstructive lesions, the risk of cardiovascular complications is conditioned by almost 100% presence of hypertension, high body mass index values, a significant frequency of obesity, dyslipidemia, carbohydrate metabolism disorders, and high biological age.
Early manifestation of infantile Pompe disease (case report)
Authors:   Astrakhan State Medical University, Sagitova G.R. , Davydova O.V. ,   Astrakhan State Medical University, Antonova А.А. ,   Astrakhan State Medical University, Ilyenko T.L. ,   Regional Children’s Clinical Hospital named after N.N. Silishcheva
Published: September 2022

Despite the fact that more than 70% of hereditary diseases can be considered rare, their prevalence in the population is 2%. Pompe disease (glycogen storage disease type II, glycogenosis type II) is a rare genetic disease that is accompanied with a damage to muscle cells and nerve fibers due to the accumulation of glycogen in them. The latter is due to a deficiency of the acid alpha-glucosidase enzyme. The relevance of Pompe disease is due to her rarity and the set of nonspecific symptoms, as well as the fact that it can manifest at any age. Depending on the onset, early infantile and late adult forms are distinguished. The early infantile form of Pompe disease manifests itself from the first months of life, the clinic includes generalized muscle weakness, frequent respiratory infections, macroglossia, hepato- and cardiomegaly. The article describes a case of infantile Pompe disease in a child of the first year of life, which shows that without the results of specific tests, including genetic ones, the diagnosis will not be verified, and the way to a reasonable assignment of such tests often turns out to be long. A pediatrician, as well as subspecialist physicians, should be wary of infants with unusual combinations of symptoms, multiple organ lesions, since it is extremely important to transfer such a child for a consultation with a geneticist in a timely manner. Such actions will help not only save lives, but also preserve the quality of life of these patients. Due to the complexity of diagnosis, today it is promising to include Pompe disease in the list of diseases for newborn screening. In this case, the treatment will be preventive and will not allow the symptoms of the disease to develop. Preventive therapy will allow not only reduce the risk of fatal outcome in Pompe disease, but also significantly decrease the percentage of disability.
The risk of suicidal behavior in depression in the structure of bipolar disorder complicated by plant cannabinoid addiction
Authors:   Novosibirsk State Medical University, Klimova I.Yu. , Ovchinnikov A.A. ,   Novosibirsk State Medical University
Published: September 2022

Introduction. According to clinical observations, depressive states in the structure of bipolar disorder (BD) are observed in 23.8% of the examined patients. Most studies show that compared with the general population, the standardized mortality rate in patients is about 30%; BD patients account for 1.4% of total deaths. Aim. To assess the risk of suicidal behavior in depression in the structure of BD complicated by plant cannabinoid ad¬diction. Materials and methods. For this research, 58 patients with diagnosed BD associated with the syndrome of cannabinoid addiction were selected – the main group (mean age 34 ± 4 years). The control group consisted of 100 individuals with BD without associated pathology (mean age 32 ± 3 years). The duration of the disease in both groups ranged from 1 to 5 years. The following methods and scales were used in the study: clinical method – mental status assessment, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the SAD PERSONS Scale – a scale for suicide risk assessment. Results. The study showed that the risk of suicidal behavior in depression in the structure of BD complicated by plant cannabinoid addiction increases significantly, which is confirmed by the results of assessment using psychometric scales (after 6 months since the beginning of the study in the main group, a high risk of suicide was diagnosed in 8% of cases, after 12 months – in 11%, very high risk – in 4% of cases). The deterioration of the mental state was confirmed by the frequency and longer duration of hospitalizations in a psychiatric hospital: in the main group, the average duration of hospitalization in a psychiatric hospital after 6 months since the beginning of the study was about 5.3 ± 2 months (67% (p < 0.005)), after 12 months – about 5.9 ± 1 months (72% (p < 0.005)). In the treatment of this category of patients, high drug resistance was noted (73–86% (p < 0.05)). Conclusion. The use of plant cannabinoids increases the risk of suicidal behavior. Depression in the structure of BD associated with plant cannabinoid addiction was characterized by resistance to therapy. An increase in anxiety levels led to compulsive suicide attempts which is a key risk factor for completed suicide.
Phytochemical and botanical study of a prospective medicinal plant, Nonea rossica Steven
Authors:   Novosibirsk State Medical University, Velichko V.V. , Kartashova M.E. ,   Novosibirsk State Medical University, Kruglov D.S. ,   Novosibirsk State Medical University
Published: September 2022

Introduction. Nonea rossica Steven is a widespread in Western Siberia herbaceous plant of the Boraginaceae family. It is used in folk medicine as an antimalarial, antibacterial, analgesic, anti-inflammatory and anticoagulant agent, and in this regard, the plant is promising for study with a view to introducing it into practice as an officinal medicine. Aim. Phytochemical and morpho-anatomical study of aboveground and underground organs of Nonea rossica Steven. Materials and methods. A phytochemical analysis was performed using conventional methods. The anatomical structure of plant organs was reveal using microscopic analysis. Results. The presence and content of the main groups of biologically active substances was established: the content of flavonoids in the aboveground part in terms of rutin was 0.2%; tannins of the condensable group in aboveground parts of plant – 3.8%, in roots – 0.6%; xanthones in terms of mangiferin in roots – 0.01%, in herb – 0.008%; polysaccharides in herb – 4.37%. Microscopic analysis allowed to establish the main microdiagnostic signs of vegetative and reproductive organs of Nonea rossica Steven. Conclusion. The diverse chemical composition of Nonea rossica Steven allows us to conclude that it is promising to study the plant in order to create new medicines based on it. As a result of micromorphological examination of the aboveground and underground organs of Nonea rossica Steven, it was possible to identify diagnostic signs for the identification of raw materials, which will become the basis for the draft of a monograph.
Pengaruh Intensitas dan Terpaan Media terhadap Tingkat Kecemasan
Authors: Wulan Ayu A Zahra Byas , Samatan Nuriyati
Published: September 2022

Kehadiran teknologi komunikasi ini membuat komunikasi semakin mudah dijangkau ke pelosok negeri ataupun ke seluruh dunia. Seperti kasus Covid-19 yang ada di Indonesia, begitu deras arus informasi utnuk dapat sampai dapat ke komunikan tidak membutuhkan waktu berhari-hari melainkan hitungan menit. Penelitian ini menganalisa pengaruh intensitas dan terpaan media. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif, metode yang digunakan adalah metode survei. Teknik sampling yang digunakan adalah teknik purposive sampling. Teknik analisis data menggunakan uji korelasi berganda. Berdasarkan analisis data dapat diketahui bahwa semua variabel saling mempengaruhi. Dengan diperoleh nilai R sebesar 0,431 atau 43,1% dan sisanya sebesar 56,1% dipengaruhi variabel lain yang tidak diteliti.
Spiritual Marketing Sebagai Strategi Pemasaran Destinasi Wisata Religi
Authors: Dwihantoro Prihatin , Vianto Adi Nur
Published: September 2022

Potensi wisata yang berkembang saat ini adalah wisata religi atau yang biasa disebut dengan ziarah. Wisata religi merupakan kegiatan melakukan perjalanan dengan tujuan mendapatkan kenikmatan, kepuasan serta pengetahuan. Tujuan Penelitian ini adalah untuk mengetahui stategi promosi dan spiritual marketing yang digunakan pengelola wisata religi Makam Aulia Gunungpring serta sebagai pariwisata berkelanjutan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan pengambilan data menggunakan observasi dan wawancara untuk mendapatkan data primer dan sekunder. Teknik analisis data dilakukan dengan cara reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa Makam Aulia Gunungpring telah melaksanakan konsep spiritual marketing akan tetapi sudah secara baik. Namun, makam Aulia Gunungpring belum menerapkan strategi pemasaran melalui media sosial guna mendukung kegiatan spiritual marketing. Konsep spiritual marketing menjadi strategi pemasaran pariwisata Gunungpring yang religius dan sarat dengan nuansa budaya. Konsep spiritual marketing memiliki orientasi kepada Allah, sehingga seluruh proses dalam kegiatan pemasaran mengikuti tuntunan Islam.
Patient-Specific Drill Guide Template for Pedicle Screw Insertion into the Atlantoaxial Cervical Spine Using Stereolithographic Modeling: An In Vitro Study
Authors: Bundoc Rafael Cruz , Obenieta Harjoland Lim , Dizon Dave Anthony Gatchalian
Published: September 2022

Study Design: Cadaveric study.Purpose: This study aimed to assess the accuracy and feasibility of cervical pedicle screw (CPS) insertion into the atlantoaxial cervical spine using a patient-specific drill guide template constructed from a stereolithographic model.Overview of Literature: CPS fixation is a widely accepted procedure for posterior cervical fixation because of its biomechanical advantages, particularly in the subaxial cervical region. The extremely narrow corridors of the atlantoaxial spine make CPS insertion more difficult, requiring the development of new tools to ensure accurate placement.Methods: Fifteen atlantoaxial cervical vertebra specimens from 15 cadavers were scanned into thin slices using computed tomography. Images of the cadaver spine were digitally processed and rendered stl files so that they could be printed to scale as threedimensional (3D) plastic models. Manually molded dental acrylic drill guide templates with pins inserted in the pedicles of the plastic cervical models were placed over the 3D printed models. The drill guide templates were used for precise placement of the drill holes in the pedicles of cadaveric specimens for pedicle screw fixation. The accuracy of screw placement was evaluated by an independent evaluator.Results: A total of 60 pedicles (combined C1 and C2) from 15 cadaveric axial cervical vertebrae were evaluated. The total acceptable accuracy for pedicle screw insertion in the atlantoaxial cervical vertebrae is 95%. An accuracy rate of 100% was achieved for C1 while an acceptable accuracy rate of 90% was achieved for C2.Conclusions: The use of a patient-specific drill guide constructed using stereolithography improved the accuracy of CPS placement in a cadaveric model.
Effects of Expression of Matrix Metalloproteinases and Discoidin Domain Receptors in Ligamentum Flavum Fibrosis in Patients with Degenerative Lumbar Canal Stenosis
Authors: Torun Yusuf Mansur , Delen Emre , Doğanlar Oğuzhan , Doğanlar Zeynep Banu , Delen Özlem , Orakdöğen Metin
Published: September 2022

Study Design: This is a retrospective cohort study.Purpose: This study aimed to clarify the role of crosstalk between discoidin domain receptors (DDRs) and matrix metalloproteinases (MMPs) in the ligamentum flavum (LF) fibrosis obtained from patients with degenerative lumbar canal stenosis (DLCS).Overview of Literature: The DDRs, DDR1 and DDR2, are cell surface receptors and have an essential role in collagen fiber accumulation in several fibrotic diseases. MMPs are one of the critical factors in extracellular matrix remodeling and elastic fiber degradation in LF tissues. However, the crosstalk between DDRs and MMPs and the role of this molecular signal in LF fibrosis remain unclear.Methods: A total of 35 patients were divided into two groups in this study. Spinal surgery was performed in 23 of these patients with the diagnosis of DLCS. Twelve patients with lumbar disk herniation (LDH) were included in the control group. On axial T2-weighted magnetic resonance imaging, LF thickness was measured bilaterally at the level of the facet joint. Histology, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analyses were performed on LF tissue samples. LF tissues were stained with hematoxylin and eosin. In addition, the grade of fibrosis was histologically assessed using Masson trichrome triple staining. DDR1 and DDR2 Western blot analyses were performed. DDR1, DDR2, MMP2, MMP3, MMP9, and MMP13 expression levels were measured using qRT-PCR analysis.Results: The grade of fibrosis and LF thickness were significantly higher in the DLCS patients than in the LDH patients. DDR1 and DDR2 gene expression and protein levels in LF tissues are significantly greater in DLCS samples than in control samples, according to both qRT-PCR and Western blot analyses. In addition, we detected a significant expression of the MMP3, MMP9, and MMP13, which are known to have important roles in extracellular matrix remodeling in DLCS. Furthermore, we discovered a link between DDR protein levels and LF thickness, fibrosis, and MMP3/MMP9.Conclusions: Our results indicate that DDR1, DDR2, and MMP3 and MMP9 signals can be correlated with each other in LF tissues and be promoted LF fibrosis leading to spinal canal narrowing in patients with DLCS.
ІНФОРМАЦІЙНІ ТА КОМУНІКАЦІЙНІ ТЕХНОЛОГІЇ ЯК ЗАСОБИ ПІДВИЩЕННЯ НАВЧАЛЬНОЇ АКТИВНОСТІ МАЙБУТНІХ УЧИТЕЛІВ УКРАЇНСЬКОЇ МОВИ
Authors: Лукіянчук ІННА
Published: September 2022

The article examines information and communication technologies as a means of increasing the educational activity of future teachers of the Ukrainian language. The processes of informatization of society are revealed, under the influence of which cardinal changes take place in all spheres of life and professional activity of people: in economy, science, education, culture, health care, household sphere. The importance of the information approach as a fundamental method of scientific knowledge and the growing importance of information in society is highlighted. The concept of "educational activity of future teachers of the Ukrainian language as part of the spiritual world of the applicant's personality, as an individual psychological quality is manifested in awareness of learning goals, in the formation of educational and cognitive attitude to effective mastery of knowledge and methods of activity, orientation and stability of cognitive interests strong-willed efforts to achieve high learning outcomes. There are four areas of informatization of education, different in their tasks, as well as the role of computers and means of communication in the educational process. The characteristic features of information technologies, the implementation of which is carried out with the help of microprocessor, computer ("computer") technology, are shown. The main tasks of information learning technologies are highlighted, including the development of interactive environments for managing the process of activating learning activities and access to modern information and educational resources (multimedia textbooks and textbooks based on hypertext, various databases, educational sites and other sources). The peculiarity of most information and communication technologies in education is revealed. Systematized expediency of using a computer as a learning tool for independent study of the course; individualization of training; implementation of the principle of clarity (as an "electronic board", to observe the "invisible" in nature, simulated by a computer, etc.); development of applicants' thinking (by solving professional problems, modeling, programming); increase motivation to learn (use of multimedia tools, educational game programs, simulation games). The provisions in the choice and use of technologies in the educational process are highlighted
ФОРМУВАННЯ ГОТОВНОСТІ ПЕДАГОГІВ ДО ОРГАНІЗАЦІЇ ДИСТАНЦІЙНОГО НАВЧАННЯ В УМОВАХ КАРАНТИНУ
Authors: КОЛОМІЄЦЬ АЛЛА , Жовнич Олеся , КОЛОМІЄЦЬ Тарас
Published: September 2022

The article analyzes the readiness of students and teachers of the Pedagogical University to organize distance learning. Problems of self-education of future teachers in quarantine conditions were clarified. It is shown that students successfully cope with tasks that test their knowledge, skills and abilities, and much worse perform all those tasks, the correct solution of which depends on the educational activities individual components’ formation level – independent study of scientific literature, independent information retrieval, skills to use information from one discipline in classes from another. It was concluded that in the distance teaching of each discipline are relevant: organic combination in the process of learning theoretical knowledge and practical skills; independent work with different sources of information; various forms of classes and presentations of educational material; use of materials from the Internet during classes and in independent work of students; use of tasks for independent search of the necessary information, its integration and structuring; individual approach to control and evaluation of students' knowledge and skills. The authors proposed a system of organizational and methodological measures to increase the level of readiness of students and teachers of pedagogical university to organize distance learning (methodological seminars, webinars, scientific and practical conferences, collective and individual projects, computer presentations of educational material and scientific materials, etc.). The effectiveness of the proposed organizational and methodological measures was proved by the methods of mathematical statistics.
ВИКОРИСТАННЯ ІКТ ПІД ЧАС САМОСТІЙНОЇ РОБОТИ СТУДЕНТІВ З ВИЩОЇ МАТЕМАТИКИ
Authors: Рибалко Антоніна
Published: September 2022

n recent decades in view of incessant economic progress and global informatization the requirements for higher education have undergone qualitative changes. The future specialist is required to be competitive and be able to continuous professional development throughout life. In this context, the role of students in the educational process has changed: nowadays the study has turned from passive acquisition of knowledge into fruitful cooperation between teacher and student.Significant impetus for the development of this type of cognitive activity were the force majeure circumstances of recent years. First, teachers had to change the format of training because of COVID-19 pandemic, and now we have to overcome many of the problems of wartime. This article is devoted totopical issues of organization of independent work of students with the use of information and communication technologies.At first the author identifies the stages of organization of independent work of students in teaching higher mathematics to studentsof computer specialties. The list of different types of tasks of theoretical and practical nature, which are provided for independent study are determined. For each type of tasks the possibilities of using information and communication technologies in theprocess of their completion are considered.The basis for the organization of independent work of students is an electronic course on the Moodle platform, which contains educational materials as well as interactive elements for self-diagnosis and submission of assignments for verification. Students use computer mathematics systems MatLab, Octave, Wolfram Alpha, GeoGebra when performing competency-oriented tasks. Cloud technologies (for example, Zoom) and social networks (Telegram messenger) are used to provide advisory support for students' independent work.The developed structure of independent work allows to organize effective educational and cognitive activity of students, especially in crisis conditions of pandemic and martial law. The implemented approach provides the formation of general and special competencies, promotes the development of personal potential of students and their professional realization.Further research in this area may be devoted to the development of new forms of education with regard to the development of computer technology, the introduction of modern smart technologies, various mobile applications and more.
ПІДГОТОВКА МАЙБУТНІХ ФАХІВЦІВ СФЕРИ ТУРИЗМУ В ЗВО УКРАЇНИ В КОНТЕКСТІ ФУНКЦІОНУВАННЯ СИСТЕМИ ВИЩОЇ ОСВІТИ
Authors: Здольник Богдан
Published: September 2022

A comprehensive analysis of the training of future specialists in the field of tourism in the higher education institutions of Ukraine in the context of the functioning of the higher education system was conducted. According to the results of a study of the peculiarities of the training of future specialists in the field of tourism in higher education institutions of Ukraine in the context of the functioning of the higher education system, in particular with regard to the quantitative dimension, the following was determined: there are 242 universities and 338 colleges in Ukraine, but according to the data of the National Institute of Education and Research for 2022 – 652 higher education institutions in total, with among them, 185 are registered in the UniRank system, and the specialty «Tourism» is in 118 universities and 42 colleges. It was found that the main counter-arguments regarding the excessive number of higher education institutions in Ukraine are the lack of purposefulness of the budget, increasing the demand for studying tourism by reducing the number of universities with this specialty, increasing the quality characteristics of the scientific and pedagogical staff, etc. It has been established that the training of tourism specialists began in independent Ukraine at Taras Shevchenko National University of Kyiv, where the first department was created that began to train specialists in the tourism industry, which became the starting point for the spread of the «Tourism» specialty in other higher education institutions of Ukraine. It has been proven that as of 2021, only six higher education institutions are included in the world general university rankings with the specialty «Tourism»: Kharkiv National University of Karazin, Lviv Polytechnic National University, Taras Shevchenko Kyiv National University, Ivan Franko Lviv National University, Odesa National University of Mechnikov and Chernivtsi National University of Yury Fedkovich, of which only the first three occupy the highest positions. It was determined that the peculiarities of the training of the students of the ECL bachelor and junior professional bachelor are fairly identical competencies that form multi-disciplinary knowledge from a significant range of disciplines
СУЧАСНІ ТЕНДЕНЦІЇ РОЗВИТКУ СТУДЕНТСЬКОГООСВІТНЬОГОТУРИЗМУ ЯК ОДНІЄЇ З ФОРМ ОРГАНІЗАЦІЇ НАВЧАЛЬНОГО ПРОЦЕСУ
Authors: ЗАГОРОДНІЙ СЕРГІЙ , ІВАНІЧКІНА НАТАЛЯ
Published: September 2022

The article considers the tendencies of development of student educational tourism. A brief overview of the historical basis of the emergence of educational tourism is given, student educational tourism is characterized as a socio-economic phenomenon, definition of "educational tourism" is analyzed from the point of view of domestic and foreign scientists. Certain international educational programs and projects are singled out, the characteristic of the typical program of the educational language tour is given. Leading role in the development of educational tourism belongs to specialists in the field of education. Pedagogically correctly organized tourist and educational activities of students contribute to the formation and development of professionally significant competencies of future professionals. Modern innovative processes in science and education are actively developing pedagogical theory and practice. Some educational technologies that have been successfully used before and today are relevant because they are based on the fundamental principles of education and upbringing. Such technologies, of course, include educational tourism, which is now widely used in various educational systems, is evaluated by teachers as a highly effective practice-orientedlearning technology and at the same time as a form of organization of the educational process. Practically-oriented learning technology ensures the unity of theoretical knowledge and practical skills. Educational tourism can be considered both in terms ofconsumer activity and the quality of the economic category, which implies the stages of formation, distribution and consumption of tourism educational product. There are many approaches to the interpretation of the concept of educational tourism, reflecting its various components. Education and tourism, which complement each other and are present differently in certain cases of educational tourism, remain key. This area is especially important for students because it provides an opportunity to analyze, hone the acquired knowledge and skills, and apply them in practice, to master new ones necessary for successful development in their professional field. The growing popularity of foreign internships among students of Ukrainian free economic zones can be a factor in the development of educational tourism, if the main goal of students is to study. Comparativedata on the number of participants in international educational programs among students of Vinnytsia State Pedagogical University named after Mykhailo Kotsyubynsky are given. Emphasis is placed on the potential of student educational tourism as a powerful factor in strengthening the practice-oriented component of higher education student learning.
ПРОФЕСІЙНА ІНШОМОВНА ПІДГОТОВКА ЯК ОСНОВА ЛЬОТНОЇ ОСВІТНЬОЇ ГАЛУЗІ: ІСТОРІЯ ТА РЕАЛЬНІСТЬ
Authors: Нечепорук Яна
Published: September 2022

The effective functioning of the modern aviation industry is possible only if international rules and requirements relating to global civil aviation are met. One of these requirements is the mandatory knowledge of aviation English by an aviation specialist at the level of Operational Level 4. This article considers professional foreign language training as a basis for domestic flight education. After conducting some historical research, it was determined that for some time professional foreign language training has become a fundamental requirement and educational criterion in domestic flight education. The article also considers the problem of defining the concept of «foreign language training» in flight education. The article is devoted to the study of professional foreign language training as an integral part of modern aviation education. The author also draws attention to the definitions of the general concept of «vocational education» and presents its interpretations by various scholars. The article also identifies certain pedagogical conditions that have a positive impact on the formation of key skills of future aviation professionals. The article also defines the place of learning a foreign language in the general system of training a future aviation specialist. The article also notes that professional foreign language training is the key to a successful graduate of aviation education. Such young professionals must be prepared for professional activities in the mobile, highly competitive and technological-digital world. In the context of globalization, integration of Ukraine into the European and world space, no one doubts that for successful cooperation and interaction in the world political, economic, cultural, educational space requires knowledge of foreign languages, not only for everyday needs but also for effective professional communication. The study of the concept of "training" has led to the conclusion that it is in itself quite broad and able to combine a large number of factors. «Professional foreign language training» involves the formation of knowledge of skills and abilities needed by future aviation professionals to perform their professional activities.
МОДЕЛЬ ФОРМУВАННЯ ТЕХНІКО-ТЕХНОЛОГІЧНОЇ КОМПЕТЕНТНОСТІ БАКАЛАВРІВ ПРОФЕСІЙНОЇ ОСВІТИ ЗА СПЕЦІАЛІЗАЦІЄЮ «ТРАНСПОРТ»
Authors: ХРАПАЧ ДМИТРО
Published: September 2022

The article characterizes the model of formation of technical and technological competence of bachelors of vocational education of specialization «Transport» and its structural elements: motivational-targeted, methodological, organizational-activity, control-resultative blocks. It has been proven that for the successful implementation of the developed model, the following pedagogical conditions must be met: ensuring the motivational and value attitude of students to the professional subjects of the motor transport profile through the use of active methods and interactive learning technologies; formation and development of technical and technological skills of students during intermittent practical training at motor transport companies; improvement of the content of professional training of bachelors of vocational education due to the development of methodical support based on the modular-competency approach. It was determined that an effective solution to the problem of forming the technical and technological competence of bachelors of vocational education of specialization «Transport» during their professional training is possible if the following stages are followed: motivational-diagnostic, formative, systematizing. It was concluded that the developed model is a method for the formation of technical and technological competence of bachelors of professional education of specialization «Transport», it has a holistic character, since all its structural components are interconnected and function to achieve the main goal.
РОЗВИТОК СИСТЕМИ ОСВІТИ ДОРОСЛИХУ РІЗНИХ КРАЇНАХ СВІТУ
Authors: БІДА ОЛЕНА , ГОНЧАРУК ВІТАЛІЙ , ОРОС ІЛЬДІКА , ТЮТЯ МАРИНА
Published: September 2022

In connection with globalization and demographic changes, adult education is becoming increasingly important in today's society, and similar social mechanisms exist in different countries, which determine the participation of adult education and the linkage of this participation with the results on the labor market. But mostly those who are already well educated and have a fairly favorable position in the labor market, which acts as a mechanism for increasing social inequality, are raising their education. This is especially noticeable in relation to the widespread non-formal education in all countries, which is organized at the expense of employers.The purpose of the article: to find out the role of international relations in the development of the educational system of adults in different countries of the world.Brief information about international relations in the development of adult education system in different countries is presented.
The analysis of the achievements of scientists, specialists who studied the role of adult education in the context of life and international comparison of different countries based on longitudinal data, taking into account the difference in the organization of adult education in different countries and their peculiarities. It has been found that there is a significant diversity in the level of participation of adults in adult education in different European countries. It has been found that participation in all forms of adult education (with the exception of formal education at the expense of the employer) by the countries is higher, the higher the public expenditure on education in these countries, the expenses for research and development and the social protection of the population.The basic regularities concerning participation in the formal education of adults are revealed. In some countries (Finland and partly in Denmark, Germany, USA) in formal education adults mostly come from workers with a lower initial education level and not the most confident position in the labor market, which suggests that formal education in these countries allows partially offset the social inequality that arose in the early stages of life. In some cases(in Australia, Spain, Sweden, UK) participation in formal education is due mainly to poor job market conditions. In some countries (Hungary and, to some extent, Estonia), initial social inequality is not compensated through formal adult education.