bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of specific energy consumption in CNC turning of a hardened alloy steel roll at low cutting speeds
Authors: Noor Kashif , Siddiqui Mubashir Ali , Syed Amir Iqbal
Published: July 2023

Purpose

This study was conducted to analyze the effects of machining parameters on the specific energy consumption in the computerized numerical control lathe turning operation of a hardened alloy steel roll at low cutting speeds. The aim was to minimize its consumption.

Design/methodology/approach

The design matrix was based on three variable factors at three levels. Response surface methodology was used for the analysis of experimental results. Optimization was carried out by using the desirability function and genetic algorithm. A multiple regression model was used for relationship build-up.

Findings

According to desirability function, genetic algorithm and multiple regression analysis, optimal machining parameters were cutting speed 40 m/min, feed 0.2 mm/rev and depth of cut 0.50 mm, which resulted in minimal specific energy consumption of 0.78, 0.772 and 0.78 kJ/mm3, respectively. Correlation analysis and multiple regression model found a quadratic relationship between specific energy consumption with power consumption and material removal rate.

Originality/value

In the past, many researchers have developed mathematical models for specific energy consumption, but these models were developed at high cutting speed, and a majority of the models were based on the material removal rate as the independent variable. This research work developed a mathematical model based on the machining parameters as an independent variable at low cutting speeds, for a new type of large-sized hardened alloy steel roll. A multiple regression model was developed to build a quadratic relationship of specific energy consumption with power consumption and material removal rate. This work has a practical application in hot rolling industry.
The discovery of absorptive capacity and the practice of intellectual capital mobilization within change management processes
Authors: Rooney Jim , Kaushalya Thilini , Jayawardana Ananda K. L.
Published: July 2023

Purpose

Previous studies have argued that improvement in organizational performance though change management processes is grounded in external knowledge acquisition and assimilation. However, there is ambiguity in how existing knowledge, in the form of intellectual capital (IC), is mobilized in this context. In response, this paper develops a context-based mediator model depicting the relationship between IC processes, absorptive capacity (AC) and organizational performance following the introduction of external knowledge.

Design/methodology/approach

A qualitative longitudinal case study approach is adopted, collecting data over three phases of a quality improvement program over a three-year period.

Findings

With the development of relational capital facilitated thorough changes in the work environment and the structured enhancement of knowledge-processing capabilities, the study identified the mediating role of AC on the relationship between IC mobilization and improved organizational performance.

Originality/value

Whilst there have been studies of relationships between IC and organization performance, to the best of the “authors” knowledge, this is one the few empirical studies to explore associations between IC types, existing knowledge sharing processes and IC mobilization, mediated by the AC of a firm, to exploit external knowledge.
Does sharia-compliant debt financing reduce stock price crash risk?
Authors: Brahmana Rayenda Khresna , Kontesa Maria
Published: July 2023

Purpose

This paper examines the impact of sharia-compliant debt financing on stock price crash risk. Unlike those previous studies that took Sukuk or sharia-compliant firms, this study tests the impact of the proportion reported sharia-compliant debt financing in the balance sheet on the risk of price crash of a firm.

Design/methodology/approach

Using the data from 2,752 firm-year observations of 344 Malaysian non-financial listed companies from 2012 to 2019, this article used a robust panel data estimation technique for statistical inferences. This study also employs panel GMM and quantile least squares as the robustness check.

Findings

This study established a negative relationship between sharia-compliant debt financing and stock price crash risk. The robustness checks with different estimation techniques confirm the results. It implies that firms with a more significant proportion of Sharia-compliant financing tend to have lower future stock price crash risk.

Practical implications

Consistent with the Islamic finance literature, the present study contributes to the existing literature on Islamic capital markets from the perspective of stock price crash risk because it is vital for risk management and investment decision-making as a measure of tail risk for stocks. The findings of this research will assist investors in developing portfolio strategies that incorporate firms with higher levels of sharia-compliant debt financing in their balance sheets. Additionally, the results of this study suggest that policymakers and regulatory bodies should consider revising their monitoring approaches for publicly listed firms.

Originality/value

This study is interesting and unique, as it is a pioneer in testing the impact of sharia-compliant debt financing on reducing stock price crash risk.
Differences in use of high‐ and low‐value health care between immigrant and US‐born adults
Authors: Park Sungchul , Vargas Bustamante Arturo , Chen Jie , Ortega Alexander N.
Published: July 2023

Objective

To examine differences in the use of high‐ and low‐value health care between immigrant and US‐born adults.

Data Source

The 2007–2019 Medical Expenditure Panel Survey.

Study Design

We split the sample into younger (ages 18–64 years) and older adults (ages 65 years and over). Our outcome measures included the use of high‐value care (eight services) and low‐value care (seven services). Our key independent variable was immigration status. For each outcome, we ran regressions with and without individual‐level characteristics.

Data Collection/Extraction Methods

N/A.

Principal Findings

Before accounting for individual‐level characteristics, the use of high‐ and low‐value care was lower among immigrant adults than US‐born adults. After accounting for individual‐level characteristics, this difference decreased in both groups of younger and older adults. For high‐value care, significant differences were observed in five services and the direction of the differences was mixed. The use of breast cancer screening was lower among immigrant than US‐born younger and older adults (−5.7 [95% CI: −7.4 to −3.9] and −2.9 percentage points [95% CI: −5.6 to −0.2]) while the use of colorectal cancer screening was higher among immigrant than US‐born younger and older adults (2.6 [95% CI: 0.5 to 4.8] and 3.6 [95% CI: 0.2 to 7.0] percentage points). For low‐value care, we did not identify significant differences except for antibiotics for acute upper respiratory infection among younger adults and opioids for back pain among older adults (−3.5 [95% CI: −5.5 to −1.5] and −3.8[95% CI: −7.3 to −0.2] percentage points). Particularly, differences in socioeconomic status, health insurance, and care access between immigrant and US‐born adults played a key role in accounting for differences in the use of high‐ and low‐value health care. The use of high‐value care among immigrant and US‐born adults increased over time, but the use of low‐value care did not decrease.

Conclusion

Differential use of high‐ and low‐value care between immigrant and US‐born adults may be partly attributable to differences in individual‐level characteristics, especially socioeconomic status, health insurance, and access to care.
Seed biopriming for sustainable agriculture and ecosystem restoration
Authors: Singh Prachi , Vaishnav Anukool , Liu Hongwei , Xiong Chao , Singh Harikesh Bahadur , Singh Brajesh K.
Published: July 2023

The utilization of microbial inoculants in the realm of sustainable agricultural and ecosystem restoration has witnessed a surge in recent decades. This rise is largely attributed to advancements in our understanding of plant–microbe interactions, the urgency to reduce the dependence on agrochemicals and the growing societal demand for sustainable strategies in ecosystem management. However, despite the rapid growth of bio‐inoculants sector, certain limitations persist concerning their efficacy and performance under the field condition. Here, we propose that seed biopriming, an effective microbial inoculant technique integrating both biological agents (the priming of beneficial microbes on seeds) and physiological aspects (hydration of seeds for improved metabolically activity), has a significant potential to mitigate these limitations. This method increases the protection of seeds against soil‐borne pathogens and soil pollutants, such as salts and heavy metals, while promoting germination rate and uniformity, leading to overall improved primary productivity and soil health. Furthermore, we argue that a microbial coating on seeds can facilitate transgenerational associations of beneficial microbes, refine plant and soil microbiomes, and maintain soil legacies of beneficial microflora. This review article aims to improve our understanding of the seed biopriming approach as a potent and valuable tool in achieving sustainable agriculture and successful ecosystem restoration.
Going beyond richness: Modelling the BEF relationship using species identity, evenness, richness and species interactions via the DImodels R package
Authors: Moral Rafael A. , Vishwakarma Rishabh , Connolly John , Byrne Laura , Hurley Catherine , Finn John A. , Brophy Caroline
Published: July 2023

Biodiversity and ecosystem function (BEF) studies aim to understand how ecosystems respond to a gradient of species diversity. Generalised Diversity‐Interactions (DI) models are suitable for analysing the BEF relationship. These models relate an ecosystem function response of a community to the identity of the species in the community, their evenness (proportions) and interactions. The number of species in the community (richness) is included implicitly in a DI model.

It is common in BEF studies to model an ecosystem function as a function of richness; while this can uncover trends in the BEF relationship, by definition, species diversity is broader than richness alone, and important patterns in the BEF relationship may remain hidden. Here, we introduce the DImodels R package for implementing DI models. We show how richness is mathematically equivalent to a simplified DI model under certain conditions, and illustrate how using the DI multidimensional definition of species diversity can provide deeper insight to the BEF relationship compared to traditional approaches.

Using DI models can lead to considerably improved model fit over other methods; it does this by incorporating variation due to the multiple facets of species diversity. Predicting from a DI model is not limited to the study design points, the model can interpolate or extrapolate to predict for any species composition and proportions (assuming there is sufficient coverage of this space in the study design).

Expressing the BEF relationship as a function of richness alone can be useful to capture overall trends. However, collapsing the multiple dimensions of species diversity to a single dimension (such as richness) can result in valuable ecological information being lost. DI modelling provides a framework to test the multiple components of species diversity in the BEF relationship. It facilitates uncovering a deeper ecological understanding of the BEF relationship and can lead to enhanced inference. The open‐source DImodels R package provides a user‐friendly way to implement this modelling approach.
Why should we compare morphological and molecular disparity?
Authors: van den Ende Conrad , Puttick Mark N. , Urrutia Araxi O. , Wills Matthew A.
Published: July 2023

Indices of morphological disparity seek to summarise the highly multivariate morphological variation across groups of species within clades, time bins or other groups. Morphological variation can be quantified using geometric morphometric, outline or surface‐based methods. These are most effective when morphological differences are relatively modest and there are numerous ubiquitous landmarks and phase aligned features of shape variation. The most disparate samples, such as those across classes and phyla, typically necessitate the use of discrete characters. Unfortunately, such characters are often compiled subjectively in a manner reflecting the level of morphological and taxonomic focus and the intensity of taxon sampling.

Sampling intensity is often highly variable within a single data set, especially in repurposed and amalgamated cladistic matrices. Here, we propose indices of molecular disparity analogous to those of morphological disparity. Despite numerous shortcomings discussed here, molecular sequence data can be obtained in a more objective, automated and scalable manner than morphological data.

Comparisons of the morphological and molecular disparity of subclades in 16 large data sets suggest that molecular disparity is less susceptible to sampling biases than morphological disparity. Moreover, distance matrices inferred from individual genes tend to correlate strongly with each other and with distances from all concatenated genes. By contrast, morphological and molecular disparity are typically not significantly correlated across subclades, such that comparisons for groups can help to give a fuller picture of their evolution. For example, within mammals, Afrotheria have conspicuously high morphological disparity but modest molecular disparity, suggesting unusually high morphological plasticity. Even more strikingly, the molecular disparity of rodents is over five times that for Artiodactyla, despite having only half of their morphological disparity. These contrasts suggest the differential operation of geometric, biomechanical, ontogenetic and environmental constraints on form.

Given the increasing abundance of total evidence datasets in the literature and the widespread and sometimes uncritical repurposing of discrete morphological matrices, we propose the comparison of morphological and molecular disparity as a useful tool to understand subclade evolution more fully.
Irrigation with reduced sodium hypochlorite solution concentration using laser‐induced cavitation is effective and safe in rat intraradicular biofilm model
Authors: Uematsu Takehiro , Yahata Yoshio , Ohnishi Koyuki , Suzuki Shigeto , Kanehira Masafumi , Tanaka Toshinori , Sudo Susumu , Suresh Venkata Venkataiah , Saito Masahiro
Published: July 2023

This study aimed to investigate the optimal sodium hypochlorite solution (NaOCl) concentration to effectively remove the root canal biofilm without stimulating periradicular inflammation using coronal laser‐activated irrigation (CLAI). To compare the efficacy of different NaOCl concentrations combined with CLAI in removing the biofilm, an in vivo intraradicular biofilm rat model was used. Root canals were irrigated using an Er:YAG laser with either 5% or 0.5% NaOCl. Biofilm removal efficacy of CLAI was compared to that of conventional needle irrigation using scanning electron microscopy (SEM) and quantitative polymerase chain reaction (qPCR). Histological observation of CLAI‐associated periradicular inflammation was also conducted. In both the 5% and 0.5% CLAI groups, SEM observation showed the opening of the dentin tubules and biofilm removal. qPCR analysis indicated that the residual bacteria counts after cleaning were significantly lower in the 5% and 0.5% CLAI groups than in the conventional needle irrigation and positive control groups (Tukey test, p < 0.05), and no significant difference was observed between the 5% and 0.5% CLAI groups (p > 0.05). Periapical inflammation in the 5% CLAI group revealed the most severe, including significant neutrophilic and lymphocytic infiltration with abscess formation, while only mild vasodilation was observed in the 0.5% CLAI group. CLAI can remove the biofilm independently of chemical action, which avoids the risks associated with high NaOCl concentrations. Therefore, this root canal irrigation technique ensures safety and effectiveness, promising to contribute to new treatment strategies intended to remove intraradicular biofilm.
Keeping or Building Peace? UN Peace Operations beyond the Security Dilemma
Authors: Campbell Susanna P. , Di Salvatore Jessica
Published: July 2023

One of the most consistent findings on UN peace operations (UNPOs) is that they contribute to peace. Existing scholarship argues this is because UNPOs' peacekeeping troops solve the security dilemma that inhibits combatant disarmament and prevents their political leaders from sharing power. We argue that existing scholarship's focus on peacekeeping troops overlooks UNPOs’ role in enabling governments to implement redistributive power‐sharing reforms contained in peace agreements, along with their broader peace processes. While peacekeeping troops can help belligerents refrain from violence, military force alone cannot explain how political elites implement redistributive reforms that threaten their status. We argue that UNPOs that have predominant peacebuilding (as opposed to peacekeeping) mandates help sustain political elites’ commitment to implementing peace agreement reforms and, thus, contribute to inclusive peace (increased political inclusion and reduced violence). We test our argument using a data set on UNPO mandates and original fieldwork on three sequential UNPOs in Burundi.
Palliative resection of the primary tumour improves survival in incurable metastatic colorectal cancer
Authors: Inci Kamuran , Nilsson Bengt , Lyckenblad Klara , Lindskog Stefan , Giglio Daniel
Published: July 2023

Background

Studies show conflicting results on whether primary tumour resection (PTR) in metastatic colorectal cancer (mCRC) prolongs survival. The aim of this study was to analyse prognostic factors and the effects of PTR on overall survival (OS) in mCRC patients.

Methods

In this population‐based cohort study, factors associated with PTR and OS were assessed in 188 mCRC patients with mCRC treated with palliative chemotherapy between 2008 and 2019. The Chi‐square test and Mann–Whitney U‐test were used to assess factors associated with PTR. The log‐rank test was used to compare Kaplan–Meier estimates for OS. Cox regression was used to identify factors predicting OS.

Results

Patients undergoing PTR had significantly better performance status, fewer metastatic sites, lower CEA levels, and more often had left‐sided CRC than patients not undergoing PTR. OS was longer in palliative mCRC patients undergoing PTR (P < 0.01) and PTR was an independent variable in the Cox regression analysis (P < 0.05). Median OS was 22.9 ± 1.9 months for the PTR group and 14.5 ± 1.5 months for the non‐operated group. Poor performance status and liver metastases were significantly associated with poor prognosis.

Conclusion

This study shows that PTR had a positive effect on OS and may be considered in patients suitable for surgery. PTR was offered to palliative mCRC patients with prognostic factors associated with better prognosis.
Eventration of diaphragm with ectopic thoracic kidney: A cause of chronic debilitating flank pain, managed via robot‐assisted approach
Authors: Kumar Santosh , Deshpande Rohit Sanjay
Published: July 2023

Usually, flank pain signifies the presence of a renal/ureteric pathology. Here, we highlight an unusual cause of flank pain, which can be an important differential to be borne in mind while evaluating the causes of flank pain. Anatomical variants of the kidneys are very common, but rarely do they cause flank pain unless associated with an ongoing pathological process within them. We describe a case wherein an anatomical variant of the kidney, without any pathology, led to unremitting flank pain, purely due to its location and associated “vascular drag.” Correction of the underlying anatomical defect afforded significant symptomatic relief.
Chasing footprints in time – reframing our understanding of human foot function in the context of current evidence and emerging insights
Authors: Behling Anja‐Verena , Rainbow Michael J. , Welte Lauren , Kelly Luke
Published: July 2023

In this narrative review we evaluate foundational biomechanical theories of human foot function in light of new data acquired with technology that was not available to early researchers. The formulation and perpetuation of early theories about foot function largely involved scientists who were medically trained with an interest in palaeoanthropology, driven by a desire to understand human foot pathologies. Early observations of people with flat feet and foot pain were analogized to those of our primate ancestors, with the concept of flat feet being a primitive trait, which was a driving influence in early foot biomechanics research. We describe the early emergence of the mobile adaptor–rigid lever theory, which was central to most biomechanical theories of human foot function. Many of these theories attempt to explain how a presumed stiffening behaviour of the foot enables forward propulsion. Interestingly, none of the subsequent theories have been able to explain how the foot stiffens for propulsion. Within this review we highlight the key omission that the mobile adaptor–rigid lever paradigm was never experimentally tested. We show based on current evidence that foot (quasi‐)stiffness does not actually increase prior to, nor during propulsion. Based on current evidence, it is clear that the mechanical function of the foot is highly versatile. This function is adaptively controlled by the central nervous system to allow the foot to meet the wide variety of demands necessary for human locomotion. Importantly, it seems that substantial joint mobility is essential for this function. We suggest refraining from using simple, mechanical analogies to explain holistic foot function. We urge the scientific community to abandon the long‐held mobile adaptor–rigid lever paradigm, and instead to acknowledge the versatile and non‐linear mechanical behaviour of a foot that is adapted to meet constantly varying locomotory demands.
Design thinking impact on value creation and value capture on innovation projects
Authors: e Silva Gabriel Delage , Zancul Eduardo
Published: July 2023

Design thinking has proven to be an effective approach to driving innovation in diverse contexts and has attracted increasing interest from scholars and practitioners. However, the plurality of points of view about design thinking can bring diffuse understandings and hinder a cohesive perspective on the construct. This work continues the research stream to provide greater specificity about design thinking practice. The paper focuses on new solution development projects, investigating how design thinking contributes to advance from value creation to value capture—which are two fundamental achievements of successful innovations. Based on three in‐depth case studies of new product development conducted in healthcare innovation projects, this work indicates that design thinking is more prone to promoting value creation rather than value capture. Design thinking principles work as a compass that guides the development team, getting clues from users to direct the value creation. In addition, the study shows the importance of complementing design thinking with specialist knowledge to build solutions that can create value. Finally, the study shows that value capture is not an immediate outcome of design thinking. Therefore, this work indicates the need to complement design thinking with business‐oriented approaches to provide market‐related results.
Parents' perceptions: Participation patterns and desires for change for children and adolescents with autism spectrum disorder—A descriptive population‐based study from Switzerland
Authors: Krieger Beate , Piškur Barbara , Beurskens Anna J. H. M. , Moser Albine
Published: July 2023

Background

Low participation in youth with autism spectrum disorder (ASD) has been reported, but age‐related and contextual information is rare.

Objective

This study aimed to describe, from parental perspectives, two patterns of participation and parental desires for change of children (age: 5–11) and adolescents (age: 12–17) with ASD in Switzerland.

Method

A cross‐sectional design used the German version of the Participation and Environment Measure‐Child and Youth to describe and juxtapose the participation results of 60 children and 55 adolescents with ASD in 45 activities at home, school and in the community and parental desires for change.

Results

Participation patterns differed between settings and age groups. Both groups were found to participate most at home, followed by school, whereas community participation was either low or nonexistent. Children were more involved at home than adolescents, while school involvement was higher than participation frequency in both age groups. Community participation frequency was generally low but higher in children than in adolescents, while involvement was similarly low in both groups. Half the parents expressed desire for change with three tendencies: (1) widespread desire for change at home due to high support needs, (2) parents of adolescents expressed more desire for change in all settings than those of children and (3) all parents mainly desired to increase participation frequency and involvement.

Conclusions

This study informs research and social, health and community service providers to further reshape their programmes to meet parental needs and increase the participation of youth with ASD.
Real or fake? Sourcing and marketing of non‐prescribed benzodiazepines amongst two samples of people who regularly use illicit drugs in Australia
Authors: Grigg Jodie , Peacock Amy , Lenton Simon , Salom Caroline , Agramunt Seraina , Thomas Natalie , Lyons Tom , Sutherland Rachel
Published: July 2023

Introduction

There is concern around non‐prescribed benzodiazepine use, particularly with increasing detections of counterfeit products containing high‐risk novel compounds. The aims of this study were to investigate how and which non‐prescribed benzodiazepines are being sourced; forms, appearance and packaging; and awareness of risks associated with non‐prescribed benzodiazepines.

Methods

Data were collected from a sample of Australians who inject drugs or use ecstasy and/or other illicit stimulants on a monthly or more frequent basis, and who reported past 6‐month use of non‐prescribed benzodiazepines (n = 235 and n = 250, respectively). Data were collected on source, diversion from a known/trusted prescription, product name and aesthetic characteristics for the last non‐prescribed benzodiazepine obtained.

Results

Amongst participants who injected drugs, 71% reported that their last non‐prescribed benzodiazepines were diverted from a known/trusted prescription, compared to 59% of participants who used ecstasy/other stimulants. Sourcing via cryptomarkets was rare. Across both samples, the majority reported last obtaining substances sold/marketed as diazepam or alprazolam. Participants sourcing via non‐diverted means were twice as likely to obtain alprazolam. Known sourcing of novel compounds was rare. Amongst participants who used ecstasy/other stimulants, 36% reported confidence in the content/dose of non‐prescribed benzodiazepines even when the source is unknown.

Discussion and Conclusions

Most participants obtained substances sold as classic/registered benzodiazepines, mostly via diverted prescriptions, with a substantial minority potentially unaware of counterfeits circulating. While diverted use undeniably presents risks, tightening of prescriptions in Australia could inadvertently lead to greater supply of novel benzodiazepines as seen internationally, reinforcing prioritisation of demand and harm reduction strategies.
Motivated to vote? The effect of flooding on political participation
Authors: Jusko Jakub , Spáč Peter
Published: July 2023

This paper investigates changes in political participation following a disaster. Drawing on the electoral results and flood declarations after the 2010 flood in Slovakia, a dataset was constructed that illustrates when and how often each municipality was affected by disastrous conditions before the elections. The analysis revealed that experiencing a flood significantly increased the level of political participation in a municipality. However, the effect of flooding on elections is conditional. First, significantly higher turnout occurs only when a flood affects the municipality on election day. Second, repeated flooding before the elections does not change the overall participation rate. In contrast, it is the one‐time, continuous extreme weather event that most mobilises voters. Third, only severely affected municipalities demonstrated a significant turnout effect. Lastly, the timing variable is crucial in determining the impact of repetition and severity. This paper distinguishes between different kinds of flood events that can influence disaster behaviour.
Childhood outcomes after low‐grade intraventricular haemorrhage: A systematic review and meta‐analysis
Authors: Rees Philippa , Callan Caitriona , Chadda Karan R. , Diviney James , Harnden Fergus , Gardiner Julian , Battersby Cheryl , Gale Chris , Sutcliffe Alastair
Published: July 2023

Aim

To undertake a systematic review and meta‐analysis exploring school‐age neurodevelopmental outcomes of children after low‐grade intraventricular haemorrhage (IVH).

Method

The published and grey literature was extensively searched to identify observational comparative studies exploring neurodevelopmental outcomes after IVH grades 1 and 2. Our primary outcome was neurodevelopmental impairment after 5 years of age, which included cognitive, motor, speech and language, behavioural, hearing, or visual impairments.

Results

This review included 12 studies and over 2036 infants born preterm with low grade IVH. Studies used 30 different neurodevelopmental tools to determine outcomes. There was conflicting evidence of the composite risk of neurodevelopmental impairment after low‐grade IVH. There was evidence of an association between low‐grade IVH and lower IQ at school age (−4.23, 95% confidence interval [CI] –7.53, −0.92, I2 = 0%) but impact on school performance was unclear. Studies reported an increased crude risk of cerebral palsy after low‐grade IVH (odds ratio [OR] 2.92, 95% CI 1.95, 4.37, I2 = 41%). No increased risk of speech and language impairment or behavioural impairment was found. Few studies addressed hearing and visual impairment.

Interpretation

This systematic review presents evidence that low‐grade IVH is associated with specific neurodevelopmental impairments at school age, lending support to the theory that low‐grade IVH is not a benign condition.

What this paper adds

The functional impact of low‐grade intraventricular haemorrhage (IVH) at school age is unknown.

Low‐grade IVH is associated with a lower IQ at school age.

The risk of cerebral palsy is increased after low‐grade IVH.

Low‐grade IVH is not associated with speech and language impairment.
Hotspots: Adherence in home foot temperature monitoring interventions for at‐risk feet with diabetes—A narrative review
Authors: Jones Petra J. , Lavery Lawrence , Davies Melanie J. , Webb David , Rowlands Alex V.
Published: July 2023

Background

Home foot temperature monitoring (HFTM) is recommended for those at moderate to high ulcer risk. Where a > 2.2°C difference in temperature between feet (hotspot) is detected, it is suggested that individuals (1) notify a healthcare professional (HCP); (2) reduce daily steps by 50%. We assess adherence to this and HFTM upon detecting a recurrent hotspot.

Methods

PubMed and Google Scholar were searched until 9 June 2023 for English‐language peer‐reviewed HFTM studies which reported adherence to HFTM, daily step reduction or HCP hotspot notification. The search returned 1030 results excluding duplicates of which 28 were shortlisted and 11 included.

Results

Typical adherence among HFTM study participants for >3 days per week was 61%–93% or >80% of study duration was 55.6%–83.1%. Monitoring foot temperatures >50% of the study duration was associated with decreased ulcer risk (Odds Ratio: 0.50, p < 0.001) in one study (n = 173), but no additional risk reduction was found for >80% adherence. Voluntary dropout was 5.2% (Smart mats); 8.1% (sock sensor) and 4.8%–35.8% (infrared thermometers). Only 16.9%–52.5% of participants notified an HCP upon hotspot detection. Objective evidence of adherence to 50% reduction in daily steps upon hotspot detection was limited to one study where the average step reduction was a pedometer‐measured 51.2%.

Conclusions

Ulcer risk reduction through HFTM is poorly understood given only half of the participants notify HCPs of recurrent hotspots and the number of reducing daily steps is largely unknown. HFTM adherence and dropout are variable and more research is needed to determine factors affecting adherence and those likely to adhere.
Environmental responses of fruiting fungal communities are phylogenetically structured
Authors: Koskinen Janne , Abrego Nerea , Vesterinen Eero , Roslin Tomas , Nyman Tommi
Published: July 2023

Through their ephemeral reproductive structures (fruiting bodies), ectomycorrhizal forest soil fungi provide a resource for a plethora of organisms. Thus, resolving what biotic and abiotic factors determine the occurrence and abundance of fruiting bodies is fundamental for understanding the dynamics of forest trophic networks. While the influence of abiotic factors such as moisture and temperature on fungal fruiting are relatively well established, little is known about how these processes interact with the evolutionary history of fungal species to determine when, where, and in which abundance fungal fruiting bodies will emerge. A specific knowledge gap relates to whether species' responses to their environment are phylogenetically structured. Here, we ask whether related fungal taxa respond similarly to climatic factors and forest habitat characteristics, and whether such correlated responses will affect the assembly of fungal fruiting communities. To resolve these questions, we fitted joint species distribution models combining data on the species composition and abundance of fungal fruiting bodies, environmental variation, and phylogenetic relationships among fungal taxa. Our results show that both site‐level forest characteristics (dominant tree species and forest age) and climatic factors related to phenology (effective heat sum) greatly influence the occurrence and abundance of fruiting bodies. More importantly, while different fungal species responded unequally to their shared environment, there was a strong phylogenetic signal in their responses, so that related fungal species tended to fruit under similar environmental conditions. Thus, not only are fruiting bodies short‐lived and patchily distributed, but the availability of similar resources will be further aggregated in time and space. These strong constraints on resource availability for fungus‐associated taxa highlight the potential of fungus‐based networks as a model system for studies on the ecology and evolution of resource–consumer relations in ephemeral systems of high spatiotemporal patchiness.
Opicapone versus entacapone: Head‐to‐head retrospective data‐based comparison of healthcare resource utilization in people with Parkinson's disease new to catechol‐O‐methyltransferase (COMT) inhibitor treatment
Authors: Harrison‐Jones Glynn , Marston Xiaocong Li , Morgante Francesca , Chaudhuri K. Ray , Castilla‐Fernández Guillermo , Di Foggia Valentina
Published: July 2023

Background and purpose

Motor fluctuations are a significant driver of healthcare resource utilization (HCRU) in people with Parkinson's disease (pwPD). A common management strategy is to include catechol‐O‐methyltransferase (COMT) inhibition with either opicapone or entacapone in the levodopa regimen. However, to date, there has been a lack of head‐to‐head data comparing the two COMT inhibitors in real‐world settings. The aim of this study was to evaluate changes in HCRU and effect on sleep medications when opicapone was initiated as first COMT inhibitor versus entacapone.

Methods

In this retrospective cohort study, we assessed HCRU outcomes in pwPD naïve to COMT inhibition via UK electronic healthcare records (Clinical Practice Research Datalink and Hospital Episodes Statistics databases, June 2016 to December 2019). HCRU outcomes were assessed before (baseline) and after COMT inhibitor prescription at 0–6 months, 7–12 months and 13–18 months. Opicapone‐treated pwPD were algorithm‐matched (1:4) to entacapone‐treated pwPD.

Results

By 6 months, treatment with opicapone resulted in 18.5% fewer neurology outpatient visits compared to entacapone treatment; this effect was maintained until the last follow‐up (18 months). In the opicapone group, the mean levodopa equivalent daily dose decreased over the first year and then stabilized, whereas the entacapone‐treated group showed an initial decrease in the first 6 months followed by a dose increase between 7 and 18 months. Neither COMT inhibitor had a significant impact on sleep medication use.

Conclusions

This head‐to‐head study is the first to demonstrate, using ‘real‐world’ data, that initiating COMT inhibition with opicapone is likely to decrease the need for post‐treatment HCRU versus initiation of COMT inhibition with entacapone.
Real‐world considerations regarding the use of the combination of levodopa, carbidopa, and entacapone (Stalevo®) in Parkinson's disease
Authors: Reichmann Heinz
Published: July 2023

An important aim in long‐term levodopa therapy is to prolong the duration of symptomatic efficacy of each dose without increasing peak plasma concentrations above the threshold for the emergence of dyskinesias. One strategy is to enhance levodopa delivery to the brain by co‐administering it with inhibitors of peripheral dopa‐decarboxylase and catechol‐O‐methyltransferase (COMT). Levodopa, carbidopa and entacapone (LCE), available in a range of fixed‐dose combinations as the branded formulation Stalevo® (Orion Pharma), has been developed to address this requirement and has been in general use for 20 years, having first been evaluated in randomized controlled trials. Experience with LCE has established that improved levodopa pharmacokinetics achieved with dual‐enzyme inhibition are translated into improved clinical efficacy, including the possibility of reducing total levodopa dosage with no loss of therapeutic effect. The ease and tolerability of switching to LCE has been affirmed in the SIMCOM trial and by personal experience detailed in this review. Some 300,000 patient‐years of safety data are available for LCE, including trial data for up to 5 years. Most adverse effects associated with LCE are attributable to the levodopa component rather than the enzyme inhibitors. The hepatotoxicity observed with the class comparator tolcapone has not been observed with entacapone, the COMT inhibitor in LCE, and there is no formal requirement to monitor liver function during LCE therapy. Other common side effects include diarrhoea, which is one of the more prominent non‐dopaminergic adverse events, and urine discolouration, which is harmless but about which patients may require reassurance.
Comparison of cone‐beam and fan‐beam computed tomography and low‐field magnetic resonance imaging for detection of proximal phalanx dorsoproximal osteochondral defects
Authors: Lin Szu‐Ting , Bolas Nicholas M. , Sargan David R. , Restif Olivier , Peter Vanessa G. , Pokora Rachel , Patrick Hayley , Foote Alastair K. , Murray Rachel C.
Published: July 2023

Background

Dorsoproximal osteochondral defects commonly affect the proximal phalanx, but information about diagnosis on computed tomography (CT) and magnetic resonance imaging (MRI) is limited.

Objectives

To assess CT and MRI diagnoses of osteochondral defects, describe the lesions and compare sensitivity and specificity of the modalities using macroscopic pathology as gold standard.

Study design

Cross‐sectional study.

Methods

Thirty‐five equine cadaver limbs underwent standing cone‐beam CT (CBCT), fan‐beam CT (FBCT), low‐field MRI and pathological examination. CT and MR images were examined for proximal phalanx dorsomedial and dorsolateral eminence osteochondral defects. Defect dimensions were measured. Imaging diagnoses and measurements were compared with macroscopic examination.

Results

Fifty‐six defects were seen over 70 potential locations. On CBCT and FBCT, osteochondral defects appeared as subchondral irregularity/saucer‐shaped defects. On MRI, osteochondral defects were a combination of articular cartilage defect on dorsal images and subchondral flattening/irregularity on sagittal images. Subchondral thickening and osseous short tau inversion recovery hyperintensity were found concurrent with osteochondral defects. Compared with pathological examination, the sensitivity and specificity of diagnosis were 86% (95% confidence interval [95% CI] 75%–93%) and 64% (95% CI 38%–85%) for FBCT; 64% (95% CI 51%–76%) and 71% (95% CI 46%–90%) for CBCT; and 52% (95% CI 39%–65%) and 71% (95% CI 46%–90%) for MRI. Sensitivity of all modalities increased with defect size. Macroscopic defect dimensions were strongly correlated with CBCT (r = 0.76, p < 0.001) and moderately correlated with FBCT and MRI (r = 0.65, p < 0.001). Macroscopic measurements were significantly greater than all imaging modality dimensions (p < 0.001), potentially because macroscopy included articular cartilage pathology.

Main limitations

Influence of motion artefact could not be assessed.

Conclusions

Osteochondral defects could be visualised using both CT and MRI with sensitivity increasing with defect size. Diagnostic performance was best using FBCT, followed by CBCT then MRI, but CBCT‐measured defect size best correlated with macroscopic examination. MRI provided useful information on fluid signal associated with defects, which could represent active pathology.
NOD1 cooperates with HAX‐1 to promote cell migration in a RIPK2‐ and NF‐ĸB‐independent manner
Authors: Hezinger Lucy , Bauer Sarah , Ellwanger Kornelia , Piotrowsky Alban , Biber Felix , Venturelli Sascha , Kufer Thomas A.
Published: July 2023

The human Nod‐like receptor protein NOD1 is a well‐described pattern‐recognition receptor (PRR) with diverse functions. NOD1 associates with F‐actin and its protein levels are upregulated in metastatic cancer cells. A hallmark of cancer cells is their ability to migrate, which involves actin remodelling. Using chemotaxis and wound healing assays, we show that NOD1 expression correlated with the migration rate and chemotactic index in the cervical carcinoma cell line HeLa. The effect of NOD1 in cell migration was independent of the downstream kinase RIPK2 and NF‐ĸB activity. Additionally, NOD1 negatively regulated the phosphorylation status of cofilin, which inhibits actin turnover. Co‐immunoprecipitation assays identified HCLS1‐associated protein X‐1 (HAX‐1) as a previously unknown interaction partner of NOD1. Silencing of HAX‐1 expression reduced the migration behaviour to similar levels as NOD1 knockdown, and simultaneous knockdown of NOD1 and HAX‐1 showed no additive effect, suggesting that both proteins act in the same pathway. In conclusion, our data revealed an important role of the PRR NOD1 in regulating cell migration as well as chemotaxis in human cervical cancer cells and identified HAX‐1 as a protein that interacts with NOD1 and is involved in this signalling pathway.
Analysis of various ATP‐binding cassette transporters revealed quantification of ABCB4 as a potential diagnostic tool in primary sclerosing cholangitis (PSC)
Authors: Thoeni Cornelia , Perciani Catia T , Nakib Diana , Camat Damra , McGilvray Ian D , MacParland Sonya A , Fischer Sandra
Published: July 2023

Aims

ATP‐binding cassette transporters are important proteins in regulating bile constituent transport between hepatocytes and the bile canalicular system. Dysfunctional transporters lead to accumulation of toxic bile components within hepatocytes or the biliary system, known as cholestasis, resulting in liver damage. It has been previously reported that two particular ATP‐binding cassette transporters, ABCB4 and ABCB11, have altered expression in patients with primary sclerosing cholangitis (PSC). Interested in further analysis of expression patterns of ATP‐binding cassette transporters in PSC patients, we investigated liver samples from 201 patients, including 43 patients with PSC and 51 patients with primary biliary cholangitis patients (PBC). In addition to ABCB4 and ABCB11, we also included other ATP‐binding cassette transporters, to determine if upregulation of ABCB4 and ABCB11 is specifically found in the liver of patients with PSC.

Methods and results

Retrospectively, formalin‐fixed and paraffin‐embedded liver biopsies, resections, and explants were selected to investigate the expression of ABCB1, ABCB4, ABCB11, ABCG5/8, and FXR1 using nanoString nCounter and immunohistochemistry for validation of differently expressed transporters seen in PSC liver samples in comparison to non‐PSC liver specimens. Strikingly, ABCB4 was the only ATP‐binding cassette transporter showing increased gene and protein expression in hepatocytes of PSC livers when compared to non‐PSC liver specimens. Furthermore, ABCB4 protein expression also correlated with disease stage in PSC.

Conclusion

Our study concluded that altered ABCB4 expression is specifically seen in liver specimens of PSC patients. Therefore, quantitative ABCB4 analysis may be an additional useful tool for the histopathological diagnosis of PSC to distinguish this entity from other cholangiopathies.
Relapse of neurosymptomatic cerebrospinal fluid HIV RNA escape
Authors: Chan Terrence Y.‐H. , Marta Monica , Rackstraw Simon
Published: July 2023

Objectives

Our objectives were to investigate the characteristics of people living with HIV who presented with new or recurrent symptoms in the context of re‐emergence of cerebrospinal fluid HIV RNA escape after antiretroviral therapy (ART) modification (termed relapse of CSF HIV RNA escape).

Methods

People living with HIV‐1 with known CSF HIV RNA escape were identified, with clinical and laboratory data obtained from records in a tertiary centre. CSF HIV RNA escape was defined as quantifiable CSF HIV RNA in the presence of unquantifiable plasma HIV‐RNA or CSF HIV RNA greater than plasma HIV RNA in cases where plasma HIV‐RNA was quantifiable. Relapse was defined as a re‐emergence of CSF HIV RNA escape with new symptoms after ART therapy intensification post‐initial CSF HIV RNA escape.

Results

Among 40 people living with HIV who presented with neurosymptomatic CSF HIV RNA, eight (20%) presented with a relapse of CSF HIV RNA escape. Symptoms on relapse included confusion (n = 2), cognitive decline (n = 2), cerebellar dysfunction (n = 2) and worsening of pre‐existing seizures (n = 1). Prior to their relapse, three people underwent drug therapy modification, with two people stopping raltegravir intensification, and one person switched from tenofovir alafenamide, emtricitabine and raltegravir for a new regimen.

Conclusions

People with a relapse of CSF HIV RNA escape within this cohort presented with varied symptoms similar to their initial CSF HIV RNA escape. Clinicians should be vigilant of relapse of symptoms, particularly when simplifying ART regimens in people with CSF HIV RNA escape.