bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptomic analysis of resistance and short-term induction response to pyrethroids, in Anopheles coluzzii legs
Authors: Kefi Mary , Charamis Jason , Balabanidou Vasileia , Ioannidis Panagiotis , Ranson Hilary , Ingham Victoria A , Vontas John
Published: September 2021

BackgroundInsecticide-treated bed nets and indoor residual spraying comprise the major control measures against Anopheles gambiae sl, the dominant vector in sub-Saharan Africa. The primary site of contact with insecticide is through the mosquitoes’ legs, which represents the first barrier insecticides have to bypass to reach their neuronal targets. Proteomic changes and leg cuticle modifications have been associated with insecticide resistance that may reduce the rate of penetration of insecticides. Here, we performed a multiple transcriptomic analyses focusing on An. coluzzii legs. ResultsFirstly, leg-specific enrichment analysis identified 359 genes including the pyrethroid-binder SAP2 and 2 other chemosensory proteins, along with 4 ABCG transporters previously shown to be leg enriched. Enrichment gene families included those involved in detecting chemical stimuli including gustatory and ionotropic receptors and genes implicated in hydrocarbon-synthesis. Subsequently, we compared transcript expression in the legs of a highly resistant strain (VK7-HR) to both a strain with very similar genetic background which has reverted to susceptibility after several generations without insecticide pressure (VK7-LR) and a lab susceptible population. 232 differentially expressed genes (73 up-regulated and 159 down-regulated) were identified in the resistant strain when compared to the two susceptible counterparts, indicating an over-expression of phase I detoxification enzymes and cuticular proteins, with decrease in hormone-related metabolic processes in legs from the insecticide resistant population. Finally, we analysed the short-term effect of pyrethroid exposure on An. coluzzii legs, comparing 1hour-deltamethrin-exposed (VK7-IN) to unexposed (VK7-HR) leg transcriptomes and identified 348 up-regulated genes including those encoding for GPCRs, ABC transporters, odorant-binding proteins and members of the divergent salivary gland protein family. ConclusionsThe data on An. coluzzii leg-specific transcriptome provides valuable insights into the first line of defense in pyrethroid resistant and short-term deltamethrin-exposed mosquitoes. Our results suggest that xenobiotic detoxification is likely occurring in legs, while the enrichment of sensory proteins, ABCG transporters and cuticular genes is also evident. Constitutive resistance is primarily associated with elevated levels of detoxification and cuticular genes, while short-term insecticide-induced tolerance is linked with overexpression of transporters, GPCRs and GPCR-related genes, sensory/binding and salivary gland proteins.
m6A Demethylase FTO Promotes Tumor Progression via Regulation of Lipid Metabolism in Esophageal Cancer
Authors: Duan Xiaoran , Yang Li , Wang Liuya , Liu Qinghua , Zhang Kai , liu Shasha , Liu Chaojun , Gao Qun , Li Lifeng , Qin Guohui , Zhang Yi
Published: September 2021

BackgroundEpitranscriptomics studies have contributed greatly to the development of research on human cancers. In recent years, N6-methyladenosine (m6A), an RNA modification on the N-6 position of adenosine, has been found to play a potential role in epigenetic regulation. Therefore, we aimed to evaluate the regulation of cancer progression properties by m6A. ResultsWe found that m6A demethylase fat mass and obesity-associated protein (FTO) was highly expressed in esophageal cancer (EC) stem-like cells, and that its level was also substantially increased in EC tissues, which was closely correlated with a poor prognosis in EC patients. FTO knockdown significantly inhibited the proliferation, invasion, stemness, and tumorigenicity of EC cells, whereas FTO overexpression promoted these characteristics. Furthermore, integrated transcriptome and meRIP-seq analyses revealed that HSD17B11 may be a target gene regulated by FTO. Moreover, FTO promoted the formation of lipid droplets in EC cells by enhancing HSD17B11 expression. Furthermore, depleting YTHDF1 increased the protein level of HSD17B11. ConclusionsThese data indicate that FTO may rely on the reading protein YTHDF1 to affect the translation pathway of the HSD17B11 gene to regulate the formation of lipid droplets in EC cells, thereby promoting the development of EC. The understanding of the role of epitranscriptomics in the development of EC will lay a theoretical foundation for seeking new anticancer therapies.
Clonal Hematopoiesis in Lung Cancer and Its Impact on Liquid Biopsy Based on Targeted Deep Sequencing
Authors: Xue Yang , Wang Youyu , Li Yingmei , Liu Danni , Shao Mengqi , Liu Lei , Liao Yida , Huang Tanxiao , Zhang Jing , Mu Tianhao , Chen Shifu , Feng Gang , Jia Kegang
Published: September 2021

Background: Blood based liquid biopsy has proved its potential in enormous clinical applications, such as cancer screening, diagnosis, treatment guidance, disease tracking and monitoring. In certain scenario (e.g., molecular residual disease), it requires the technique to be able to detect mutation with very low frequency (0.001% ~ 1%). The major hurdle of ultra-sensitive circulating tumor DNA sequencing is the high background noise of plasma cell-free DNA (cfDNA) and clonal hematopoiesis (CH). Here in this study, we investigated the prevalence of CH in lung cancer patients and its interference with liquid biopsy. Methods: We retrospectively analyzed cfDNA and blood cell genomic DNA (gDNA) sequencing data sets (n=1261) from a group of Chinese lung cancer patients. Threshold (1%) and subthreshold (0.2%) for variant allele frequency were set and compared. We focused on 23 clonal hematopoiesis genes that were selected based on previous publications. Results: CH mutations were detected in 27.68% of all the patients at the threshold and 62.01% at the subthreshold, and the detection rate increased with age. DNMT3A was the most frequently mutated CH gene, accounted for more than half of the CH mutations. The CH mutations had a higher detection rate in smokers (72%) than non-smokers (59.4%) at subthreshold. VAFs of CH mutations in cell-free DNA strongly correlated with their VAFs in gDNA (Pearson’s R =0.92, p<2.2x10-16), while tumor derived somatic mutations didn’t have such correlation. Conclusion: Our study showed that clonal hematopoiesis is very common in lung cancer patients, especially when examining low frequency mutations. Sequencing of gDNA at equivalent depth is very important to filter out CH mutation in cancer liquid biopsy.
Functional Finishing of Polyester Fabric With Polystyrene-acrylic/zno Nanocomposite for Effective Dyes Filtration
Authors: Pasichnyk Mariia , Václavíková Miroslava , Gaálová Jana , Melnyk Inna , Minarik Peter
Published: September 2021

Organic dyes such as Methyl Orange (MO) and Methylene Blue (MB) are widely used in different industries, becoming one of the leading emerging water contaminants. It is urgent to develop the most suitable materials for effective elimination of the dyes as they are non-biodegradable and are not removed efficiently by the traditional treatment methods. The present work applied polystyrene-acrylic/ZnO nanocomposite on the polyester surface by blade coating and one-bath pad methods. Features of surface chemical modifications were determined by FTIR, SEM analysis, WCA, N2 adsorption-desorption isotherms. The functionalised layer can create unprecedented function of filter textile material depending on the way of treatment. The possibility of using such fabrics as ﬁlters was explored for MO and MB in the concentration of 100 ppm. Water purification occurred by 60% from methylene blue and 40% from methylene orange flowing through the padded polyester filter and the covered polyester filter for 2 min, respectively. Moreover, it was shown that a colourless reduced form of MB – leuco-methylene blue (LMB) could be created. The functionalised layer of the developed filters through hydrogen bonding between the –OH groups of styrene-acrylic molecules and the –N(CH3)2 groups on LMB can stabilise LMB.
Single-center Retrospective Analysis of One-stop Hybrid Surgery for Brain Arteriovenous Malformations
Authors: Ma Yihui , Wang Lesheng , Shi Jichun , Dong Lixin , Zhang Tingbao , Feng Yu , Gong Yan , Chen Xinjun , Zhao Wenyuan , Chen Jincao
Published: September 2021

Objectives To evaluate the safety and effectiveness of one-stop hybrid surgery of microsurgical resection combined with preoperative embolization or intraoperative angiography for brain arteriovenous malformations (bAVMs) and compare the efficacy of one-stop hybrid surgery with nonhybrid surgery (endovascular embolization alone) in the treatment of bAVMs. Methods A single-center retrospective study was performed to recruit 70 patients with bAVMs at our hospital between July 2017 and April 2020. Patients were divided into 2 groups depending on the mode of surgery: hybrid group (i.e., microsurgical resection combined with preoperative endovascular embolization or intraoperative angiography in the hybrid operating room), and nonhybrid group (i.e., endovascular embolization, stereotactic radiosurgery, or microsurgical resection alone). The hybrid group was divided into two subgroups: the microsurgical resection combined with preoperative embolization, and the microsurgical resection combined with intraoperative angiography subgroups. All patients’ demographic variables, clinical manifestations, and imaging features, postoperative complications, and long-term clinical prognosis were recorded and analyzed. Results Among 70 patients, 48 (68.6%) of whom presented cerebral hemorrhage due to bAVMs rupture. 36 (51.4%) patients in the hybrid group were treated with the combination of pre-operative embolization or intraoperative angiography combined with microsurgical resection, whereas 34 (48.6%) in the nonhybrid group underwent embolization alone. There was no statistical difference in gender, age, ruptured bAVM rate, Spetzler-Martin grades between the 2 groups. Regular clinical and radiological follow-up examinations cure rates were 94.4% in the hybrid group compared to 38.3% in the nonhybrid group (P<0.01). The percentage of patients with favorable outcomes was 94.1% in the hybrid group and 90.6% in the nonhybrid group, although this difference was not statistically significant. Conclusions One-stop hybrid surgery could be a safe and effective intervention to treat bAVMs clinically, whereas further follow-up is needed to determine the long-term effects after operation.
Investigating effect of keyboard distance on the posture and 3D moments of wrist and elbow joints using OpenSim
Authors: Gholami Milad , Choobineh Alireza , Abdoli-Eramaki Mohammad , Dehghan Azizallah , Karimi Mohammad Taghi
Published: September 2021

Background

Musculoskeletal disorders (MSDs) of the upper extremities and computer use are common in modern societies, and both show a growing trend. This study was conducted to determine the posture and 3D moments of wrist and elbow joints at different keyboard distances on a desk.
Methods

Twelve healthy right-handed male volunteers attended the motion analysis laboratory. A keyboard was placed at three different distances from the participants' bodies while performing a standard computer task. The workstation was adjusted according to ANSI/HFES-100-2007 standard for each participant to maintain comfortable ergonomic posture for controlling confounding variables. Qualisys motion capture system, OpenSim software (Ver. 4.1), and visual analog scale (VAS) were used to collect and analyze the data. Also, SPSS (Ver.16) was used to descriptive, Friedman and Wilcoxon tests.
Results

The highest levels of wrist flexion and radial deviation as well as elbow flexion and pronation were observed when the keyboard was at the edge of the desk. When the keyboard was 8 cm away from the edge of the desk, the wrist flexion, deviation, and pronation had the least values. With increasing the distance of the keyboard from the edge of the desk, the range of motion (ROM) of the wrist flexion and deviation as well as elbow flexion, supination and pronation decreased. The joint moments were not significantly different for the different studied keyboard positions (P-value > 0.05).
Conclusions

However, a cut-off point has to be specified because large keyboard distances cause high extension and flexion of the limbs. The position of the keyboard relative to the body is an important parameter in computer work and has a significant impact on the posture of the upper extremities. A keyboard should be located at a distance that allows the upper extremities to remain in a neutral position so that the risk of MSDs is reduced.
Anti-proliferative effects of the combination of Sulfamethoxazole and Quercetin via caspase3 and NFkB gene regulation: An in vitro and in vivo study
Authors: Sahyon Heba , Ramadan Eman N.M. , Althobaiti Fayez , Mashaly Mohammad M.A.
Published: September 2021

Combination therapy comprising natural polyphenols and anticancer drugs has been used to decrease the adverse effects and increase the effectiveness and antioxidant activities of the drugs. The antioxidant and anticancer effects of quercetin (Q), a nutritive polyphenol, have been observed both in vitro and in vivo. Likewise, the anticancer activity of sulfamethoxazole (S) has been demonstrated in vitro and in vivo. This study aimed to investigate the in vitro and in vivo anticancer effects of Q alone and in combination with S. The in vitro effects of S, Q, and S + Q on HCT-116, HepG2, MCF-7, and PC3 cell lines were examined. Additionally, the in vivo effects of these drugs were evaluated using Ehrlich ascites carcinoma (EAC) tumor-bearing mice. The in vitro data revealed the potent anticancer activity of S + Q through the induction of apoptosis and cell cycle arrest. The EAC-inoculated mice treated with S + Q presented with elevated SOD, GSH, CAT, and TAC levels and decreased malondialdehyde levels compared with the untreated EAC group, thus revealing the antioxidant and protective actions of S + Q against EAC cells invasion. Furthermore, the downregulation of NFkB and upregulation of the caspase3 gene in the EAC-inoculated mice treated with the S + Q indicated the induction of the apoptotic pathway and decrease in both cell proliferation and metastasis. In conclusion, the combination of S and Q might exert anticancer effects by inducing apoptosis and exhibiting selective toxicity against the cancer cells and thereby protecting the vital organs.
Reduction the Nanoparticles Generated at the Wheel–rail Contact by Applying Tap Water Lubricant at Subway Train Operational Velocities1
Authors: Lee HyunWook
Published: September 2021

The formation characteristics and reduction of nanoparticles emitted from wheel–rail contacts at subway train velocities of 73, 90, and 113 km/h under dry and water-lubricated conditions (using tap water) were studied using a twin-disk rig. The resulting number concentration (NC) of ultrafine and fine particles increased with train velocity under both conditions. Particle generation varied with slip rate under both conditions in both the particle categories studied. Further, the formation characteristics at 113 km/h under dry conditions showed a notable deviation from those under water-lubricated conditions in three aspects: (i) the maximum NC of ultrafine particles was higher than that of fine particles, (ii) the predominant peak diameter was in the ultrafine particles category, and (iii) the proportion of ultrafine particles was much higher than those of fine particles. Applying water decreased the NC of ultrafine and fine particles significantly at all tested velocities (by 54%–69% and 87%–91%, respectively). Adding water increased the NC of particles ≤35 nm in diameter, possibly owing to the increase in water vapor and mineral crystals from tap water. Overall, this study provides a reference for researchers aiming to minimize nanoparticle formation at the wheel–rail contacts by applying a lubricant.
BioRssay: An R Package for Analyses of Bioassays and Probit Graphs
Authors: Karunarathne Piyal , Pocquet Nicolas , Labbé Pierrick , Milesi Pascal
Published: September 2021

Dose-response relationships reflect the effects of a substance on organisms, and are widely used in broad research areas, from medicine and physiology, to vector control and pest management in agronomy. Furthermore, reporting on the response of organisms to stressors is an essential component of many public policies (e.g. public health, environment), and assessment of xenobiotic responses is an integral part of the World Health Organization recommendations. Building upon an R script that we previously made available, and considering its popularity, we have now developed a software package in the R environment, BioRssay, to efficiently analyze dose-response relationships. It has more user-friendly functions, more flexibility, and proposes an easy interpretation of the results. The functions in the BioRssay package are built on robust statistical analyses to compare the dose/exposure-response of various bioassays and effectively visualize them in probit-graphs.
Study of Lithium Disilicate Based Nano Glass Ceramics Containing P2O5.
Authors: Deshpande Anuradha Vilas , Satyanarayana Peddy
Published: September 2021

Multi component Lithium disilicate based glasses containing P2O5 have been synthesized by conventional melt quenching technique. The replacement of (Li2O+SiO2) by P2O5 and its nucleating effect has been discussed. Structural features of glasses were evaluated by DTA, FTIR and Raman spectroscopy. The glass samples have been converted into glass ceramics by following three stage heat treatment schedule. XRD, FESEM, HAADF imaging and EDX analysis has been carried out for glass ceramics. Vickers microhardness and Vickers indentation fracture toughness of all the glass ceramics have been measured. UV–Visible spectroscopy study has been carried out for glass ceramics to investigate the optical properties. The glass ceramic with 1.5 mol % P2O5 has highest transmittance. Glass ceramics with P2O5 ≥1 mol % having Li2Si2O5 as main phase exhibit high Vickers microhardness (Hv) about 6.71-6.82 GPa which is suitable for dental and armor applications.
Photo-induced Antiferromagnetic-ferromagnetic and Spin-state Transition in GdBaCo2O5.5 Thin Film
Authors: Zhang Yujun , Katayama Tsukasa , Chikamatsu Akira , Schuessler-Langeheine Christian , Pontius Niko , Hirata Yasuyuki , Takubo Kou , Yamagami Kohei , Ikeda Keisuke , Yamamoto Kohei , Hasegawa Tetsuya , Wadati Hiroki
Published: September 2021

Investigation of ultrafast dynamic behaviors can provide novel insights about the coupling mechanisms among multiple degrees of freedom, such as lattice, magnetism and electronic structure, in condensed matters. Here we investigate both the ferromagnetic (FM) and antiferromagnetic (AFM) ultrafast dynamics of a strongly correlated oxide system, GdBaCo2O5.5 thin film by time-resolved x-ray magnetic circular dichroism in reflectivity (XMCDR) and resonant magnetic x-ray diffraction (RMXD). A photo-induced AFM-FM transition characterized by an increase of the transient XMCDR (sensitive to FM order) beyond the unpumped value and a decay of RMXD (sensitive to AFM order) was observed. The photon-energy dependence of the transient XMCDR and reflectivity could be interpreted as a concomitant photo-induced spin-state transition (SST). The AFM-FM transition and SST couple with each other in the time domain, resulting in unusual dynamic behaviors of the magnetism.
Amino acid feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of CHO cells
Authors: Savizi Iman Shahidi Pour , Maghsoudi Nader , Motamedian Ehsan , Lewis Nathan E. , shojaosadati seyed abbas
Published: September 2021

Ammonia is a toxic byproduct of CHO cell metabolism, which inhibits cell growth, reduces cell viability, alters glycosylation, and decreases recombinant protein productivity. In an attempt to minimize the ammonium accumulation in cell culture media, different amino acids were added individually to the culture medium before the production phase to alleviate the negative effects of ammonium on cell culture performance. Among all the amino acids examined in this study, valine showed the most positive impact on CHO cell culture performance. When the cultured CHO cells were fed with 5 mM valine, EPO titer was increased by 25% compared to the control medium, and ammonium and lactate production were decreased by 23 and 26%, respectively, relative to the control culture. Moreover, the sialic acid content of the EPO protein in valine-fed culture was higher than in the control culture, most likely because of the lower ammonium concentration. Flux balance analysis (FBA) results demonstrated that the citric acid cycle was enriched by valine feeding. The measurement of TCA cycle activity supported this finding. The analysis revealed that there might be a link between promoting tricarboxylic acid (TCA) cycle metabolism in valine-fed culture and reduction in lactate and ammonia accumulation. Furthermore, in valine-fed culture, FBA outcomes showed that alanine was excreted into the medium as the primary mechanism for reducing ammonium concentration. It was predicted that the elevated TCA cycle metabolism was concurrent with an increment in recombinant protein production. Taken together, our data demonstrate that valine addition could be an effective strategy for mitigating the negative impacts of ammonium and enhancing glycoprotein production in both quality and quantity.
Compressive Strength of High-Volume Fly Ash (HVFA) Concrete as a Function of Lime Water and Curing Time
Authors: Yun Chin Mei , Rahman Md. Rezaur , Kuok Kuok King , Mersal Mohd Elfy , Liing Colin Ngu Ker , Bakri Muhammad Khusairy Bin
Published: September 2021

The compressive strength of high-volume fly ash (HVFA) concrete with varied volume percentages of 40%, 50%, and 60% was examined utilizing low calcium fly ash (Class-F) as a partial replacement for regular Portland cement in this study. On the 7th, 28th, and 56th days, the compressive strength is tested. At the 7th and 28th days, the influence of saturated lime water on the compressive strength of HVFA concrete is evaluated. The inclusion of fly ash as a replacement for Portland cement reduces the compressive strength of the HVFA concrete, according to the findings. At the 56th day, the HVFA concrete with 40% fly ash substitution has a compressive strength equivalent to the regular weight concrete. At the 28th day, it was discovered that saturated lime water was helpful in maximizing the strength of HVFA concrete with 50% fly ash substitution. There was additional information about the characterization of HVFA concrete.
Application of integrated BWM Fuzzy-MARCOS approach for coating material selection in tooling industries
Authors: Kumar Sunil , Maity Saikat Ranjan , Patnaik Lokeswar
Published: September 2021

The life of metal forming dies, and the efficiency of tooling industries depends on the mechanical and wear properties of tool steel. These properties can be further improved by depositing the ceramic coating on heat-treated tool steel. There are many coating materials available with numerous excellent properties. But problem is how to select the best coating material. Compared to various studies related to material selection problems in the contrasting area of utilization, remarkably, few research work is done in tooling industries. In the present work, we have identified eight coating materials (alternatives) and nine evaluation criteria under the consultation of an expert in the tooling application and tribological field. To deal with this coating material selection problem, an integrated fuzzy-MADM method is proposed comprising BWM and fuzzy-MARCOS. This integrated fuzzy-MADM method is used to evaluate the alternative, and the obtained results are scrutinized under extensive use of sensitivity analysis. In the first phase of analysis, seven scenarios of criteria weight change are used, which is derived by the BWM method; dynamic matrices are used in the second phase of analysis. In the third and fourth phases, obtained ranks are compared with those obtained by different weight calculation methods and ranking methods, respectively. All the phases have similar results, i.e., AlCrN/TiAlN coating (alternative Cm5) is the best coating material. What is more, the proposed method has been used to solve the published results of coating material selection. To evaluate its reliability and robustness, a four phases comparative sensitivity analysis was performed.
Forecasting tropical ENSO-induced drought conditions using sea surface height in the Western Pacific
Authors: David Carlos Primo , Custado Manuel Justin , Sekhon Natasha , Ibarra Daniel
Published: September 2021

The interannual variability of rainfall caused by the El Niño Southern Oscillation (ENSO) results in significant changes in hydrologic conditions that affect entire countries’ water supply. Forecasting ENSO and its impacts are mainly based on Central Pacific Sea surface temperature (SST) anomalies which satisfactorily correlates with timing and, to a lesser extent, the intensity of drought conditions in the Philippines and the rest of the Western Pacific during the El Niño phase. Changes in sea surface height (SSH) are also brought upon by ENSO through density changes with temperature and oceanographic processes. Here, we report that the associative nature of SSH and drought as measured by surface runoff, has a stronger correlation (r > 0.693, p < 0.05) in terms of the expected timing, with 1 to 3 months lag time, and intensity compared to using traditional ENSO SST indices from the Central Pacific. Furthermore, since SSH is co-located with its corresponding forecasted decrease in runoff, a localized prediction can be made which further increases the accuracy of this predictive tool. In the wake of a changing climate, this work demonstrates the possibility of statistically forecasting the timing of precipitation, and thus the volume of surface water availability, using local SSH as an indicator. A tool which is necessary for time-sensitive management decision making in drought-prone tropical regions.
Prevalence, Causes and associated factors for Postpartum haemorrhage (PPH) at St. Joseph referral hospital Peramiho-Songea, Tanzania; A hospital-based retrospective cross-sectional study.
Authors: Mvandal Samson Peter , Coletha Kindimba
Published: September 2021

Background

The prevalence of postpartum haemorrhage (PPH) is increasing globally that is from 6.5% in 2000 to 11% in 2016. But there are regional variations where there is decrease of PPH in some parts of Asia and increase in Africa and developed countries.
Objectives

The main objective of this study was to assess the prevalence, causes and associated factors for postpartum haemorrhage at St. Joseph referral hospital in Peramiho- Songea from November 2017 to December 2019.
Method

The retrospective cross-sectional hospital-based study was used and data was obtained from maternity hospital registry book/data base of St. Joseph mission hospital in Peramiho Songea, from November 2017 to November 2019. Descriptive data was analysed by tables and graphs.
Results

The prevalence of PPH in Peramiho referral hospital was 1.3% in 2017, 1.26% in 2018 and 1.4% in 2019. The overage prevalence for the three years is 1.3%. However, 73.3% of total prevalence is from home deliveries in rural areas. The main cause of PPH in the hospital was uterus atony (42%), retained placenta (15.5%), 3rd and 4th grade tears (11.2%), uterine rupture (8.1%) and coagulopathy (5.6%). The main attributing factors were age > 35years (34%), other antenatal pregnancy complication (27%), previous PPH (18.6%), Antenatal anaemia (16%), placenta previa, Eclampsia, preeclampsia (12%) each.
Conclusion

The prevalence of PPH from this study is slightly high with the main cause being uterine atony and affected mainly those undergone SVD where about two quarter were home deliveries. However further research studies are needed to investigate the main reason for higher home deliveries in Peramiho residence and nearby area.
Analysis of internal threats to information security of enterprises
Authors:   Irkutsk State Transport University (ISTU), Glukhov N. I. , Nasedkin P. N. ,   Irkutsk State Transport University (ISTU)
Published: September 2021

In this work the authors analyze the internal threats to information security. The article provides the research results obtained by analyzing the threats related to the information losses and presents a new approach to estimate possible damage to an enterprise by considering an ontological model of interrelation of basic concepts. Based on the ontological model the generalized formula to estimate a potential damage to an enterprise has been developed. This formula reflects the dependence of estimation of a potential damage on safety threats and their sources from the point of view of each information asset and information properties. In the work the main sources of threats, kinds of the information, expenses for the budget and basic problems in control and counteraction to internal threats of information safety are listed
Modern approaches in creating systems to manage the maintenance of control and measuring devices and automation at oil and gas production enterprises
Authors:   Samara State Technical University, Mekhtiev E. M.
Published: September 2021

The article presents the issues related to the architecture design of the control systems for maintenance and automation of measurement equipment, that includes various subsystems and elements as components for the organization of business processes for the maintenance of large industrial enterprises. Those systems take into account the current realities when creating complex digital models and the place of such systems in the information space. The functional requirements that the control system must meet during implementation are defined, and the approaches to the development and updating of service standards are proposed. Taking into account the general trend that consists in the increasing amount of information collected and processed from the field level, a variety of technological objects, as well as the increasing autonomy and complexity of control systems, the task of organizing timely maintenance and repair, and processing of the results using traditional methods, is becoming unsolvable. The ensuring of an independent assessment of the quality and timeliness of work, the impossibility of misrepresenting information about the service is becoming the key point to build transparent relationships in service organization. This article describes the methods and algorithms of business processes necessary to design and implement such systems. Based on the described methodology, an information system was developed, and an assessment of the economic effect was carried out using the results of its implementation and adaptation
On the occurrence of jahnsite/whiteite phases on Mars: A thermodynamic study
Authors: Drouet Christophe , Loche Matteo , Fabre Sébastien , Meslin Pierre-Yves
Published: September 2021

Jahnsites/whiteites are a large family of phosphate hydrate minerals of relevance to terrestrial and martian mineralogy. It was recently hypothesized as being present in Gale Crater sediments from XRD analyses performed by the CheMin analyzer aboard the Curiosity rover. However, the conditions of formation and thermodynamic properties of these compounds are essentially unknown. In this work, we have optimized the ThermAP predictive thermodynamic approach to the analysis of these phases, allowing us to estimate for the first time the standard formation enthalpy (ΔHfo), Gibbs free energy (ΔGfo), and entropy (S°) of 15 jahnsite/whiteite end-member compositions, as well as of related phases such as segelerite and alluaudites. These estimations were then used to feed speciation/phase diagram calculation tools to evaluate the relative ease of formation and stability of these hydrated minerals, including considering present martian conditions. Selected laboratory experiments confirmed calculation outcomes. All of our data suggest that the formation of jahnsites is an unlikely process, and point instead to the formation of other simpler phosphate compounds. The stability domain, as calculated here, also raises serious questions about the possible presence of jahnsites on Mars as in Gale Crater, which appears rather improbable.
Efeitos da pandemia de COVID-19 no processamento editorial de periódicos brasileiros
Authors: Galvao Tais Freire , Veçoso Luisa Von Zuben
Published: September 2021

este estudo objetivou investigar os impactos da pandemia da COVID-19 sobre a publicação e editoração científica no Brasil. Foi realizado um inquérito on-line com editores de periódicos nacionais no segundo semestre de 2020. De 1.299 questionários preenchidos, 87 foram preenchidos por editores-chefes que identificaram o nome do periódico. A maior parte das revistas pertenciam às áreas de humanidades (n=43) e ciências da vida (n=41), eram open access (n=85). Observou-se aumento nas submissões de manuscritos (n=40) e mudança da maior parte das atividades para home office. Quinze periódicos passaram a aceitar manuscritos pré-publicados e a maioria (n=50) não aceita. Políticas de promoção de equidade de gênero e raça são pouco adotadas. A pandemia afetou as atividades editoriais dos periódicos nacionais.
Pareceristas ad hoc da Revista de Epidemiologia e Controle de Infecção
Authors: Nunes Ezequiel Servegnini , Joaquim Cassiandra Sampaio , Valim Andreia Rosane de Moura , Possuelo Lia Gonçalves
Published: September 2021

Estudo descritivo retrospectivo construído através da busca e análise das características dos avaliadores da Revista de Epidemiologia e Controle de Infecção, no período de 2014 a 2020. O objetivo foi identificar o perfil dos pareceristas ad hoc da RECI. As informações foram extraídas na base de dados constante nas listas de revisores do periódico. Os resultados indicam que 39% deles têm afiliação na Região Sul. Por Estado, observa-se que o Rio Grande do Sul lidera (27%), na sequência São Paulo (12%) e Paraná (9%). Esse estudo mostra que existe uma diversificação intrarregional e aponta para a importância de prospectar avaliadores de outras regiões do país e internacionais, visando qualificar ainda mais o periódico.
Portal de Periódicos da UFJF
Authors: Pinto Priscila de Faria , Oliveira Adriana Aparecida de
Published: September 2021

Em sete anos de existência, o Portal de Periódicos da Universidade Federal de Juiz de Fora (UFJF), construído e gerido por editores e a Biblioteca Universitária, é o responsável direto pelo avanço e qualificação das revistas científicas editadas por esta universidade. Apoiado pela Pró-reitoria de Pós-graduação e Pesquisa, o Portal abriga atualmente 37 periódicos de diversas áreas do conhecimento, que possuem acesso ao DOI e a software de verificação de similaridade. A iniciativa conseguiu corrigir falhas, qualificar equipes e implementar ferramentas para gestão e melhoria das condições de editoração. Como resultado, observamos a indexação dos periódicos em bases de dados nacionais e internacionais que refletem na melhora das métricas e sustentabilidade das revistas.
Estatística dos usuários de um artigo publicado em idiomas distintos (português e inglês)
Authors: Andrade Juliana Ramos , Cruz Fernando , Valença Marcelo Moraes
Published: September 2021

Com o objetivo de descrever e comparar o quantitativo dos usuários e acessos aos resumos e arquivos completos de um artigo publicado em português e em inglês em uma revista médica brasileira recém-criada publicou o artigo “Experiência da Unimed Recife no tratamento de 1.039 pacientes com Covid-19” nos dois idiomas e acompanhamos a estatística do plugin do Open Journal Systems – OJS e Google Analytics entre março a julho de 2021. A versão em português obteve 151 visualizações e a versão inglês 147 visualizações (total de 298 visualizações). Considerando um artigo como divulgação de conhecimento, sugerimos a publicação em pelo menos dois idiomas apesar de artigos na língua portuguesa ser prejudicial na indexação dos periódicos.
Adesão das revistas brasileiras de saúde às práticas de ciência aberta pelos critérios SciELO Brasil
Authors: Araujo Lyvia , Príncipe Eloísa
Published: September 2021

As práticas de ciência aberta buscam ampliar a visibilidade e democratizar o acesso e uso do conhecimento científico. Esta pesquisa busca analisar a adesão das revistas brasileiras de ciências da saúde às práticas de ciência aberta estimuladas pelos critérios SciELO Brasil, publicados em maio de 2020. Os resultados demonstram a adesão satisfatória a algumas práticas e a baixa adesão a outras. Conclui que devem ser impulsionados: os processos de abertura da avaliação por pares, o encorajamento ao compartilhamento de dados, o encorajamento à publicação de preprints e o uso da taxonomia CRediT para o esclarecimento da contribuição dos autores.
Perbandingan Metode Pengujian Teori TAM Pada Penerimaan Teknologi E-Money di Pontianak
Authors: Wingdes Irawan , Kosasi Sandy , Yuliani I Dewa Ayu Eka
Published: September 2021

As a researcher, one could analyze Technology Acceptance Model (TAM) by utilizing several methods. Such methods are summated scales regression, factor analysis score regression, covariance-based SEM, and PLS-based SEM. However, there exists less effort to compare the difference in estimates of these methods in a single dataset. The differing estimates could therefore lead to type I statistical errors. This research purpose was to compare these methods objectively with a single dataset. The dataset tested was derived from e-money research in Pontianak, with 280 data collected at refueling stations during May, June, July 2020. This research contributes to proofing how method choices will produce a differing interpretation even though tested on the same dataset. Summated scale regression and PLS-based SEM produced similar estimation results but differed from factor analysis score regression and covariance-based SEM. Further testing implies that the different estimates are due to the elimination of indicators, which is method-specific. Therefore, method justification, completeness of research report, and research context are crucial for accounting limitation of the method chosen. PLS-based SEM was a suitable method for data utilized with 50,3% variability in usefulness, 58% variability in intention to use is accounted for from the research model.
RELATIONSHIP BETWEEN ANOREXIA NERVOSA (DESIRE FOR THINNESS) AND MENTAL HEALTH AMONG JUNIOR COLLEGE STUDENTS
Authors:   Assistant Professor, Marathwada College of Education, Aurangabad., Zeenat Muzaffar Khan
Published: September 2021

Anorexia nervosa, a type of eating disorder is commonly seen in teenagers. An intense fear of gaining weight and distorted body image compels the teenagers to go on diet, which is resulting in eating less and skipping the meal and ultimately making the teenagers more prone to stress,anxiety,depression and other mental health issues. The study was taken with an intention to find the association of anorexia and mental health. A sample of 913 adolescents from junior college were selected as sample and a standardized test was administered. The findings showed that there is a positive correlation between eating disorder and mental health among adolescents.
COMPLETE LOCOMOTION ANALYSIS OF A SMALL DIFFERENTIALDRIVE MOBILE ROBOTIC PLATFORM
Authors:   Faculty of Aeronautics and Astronautics, Tarsus University, Mersin, 33400, Turkey., Bakirci Murat
Published: September 2021

Mobile robots are becoming a part of more and more research areas due to their structural advantages and the increase in usage areas. Differential drive mobile robots are among the most preferred of this type of robots due to the convenience that they provide in engineering studies. It is quite important to test and structurally investigate primary parts such as motors and its sensors before being used in research applications. Before proceeding to further studies, it is very useful to do such tests as they may provide critical information about the robot which can be quite beneficial in terms of time, effort, and cost. To achieve this task, variety of methods are available in the literature such as structural locomotion tests and system identifiaction. In the first part of this study, locomotion tests of a small mobile robot driven by servo motors and operating with a single microcontroller was performed using the velocity propulsion mode. Three different predefined routes were determined for the robot and the accuracy of the robot moving along these routes was investigated. Through these tests, it is aimed to examine how the robot interprets the basic movements such as rectilinear forward motion, curvilinear motion, and rotation around its own axis. The next part focuses on the system identification of the robot. A data-driven model for the robotic platform was developed to make a mobile robot perform the desired movements and system identification. Various step input commands were sent to the robot under consideration and the responses of the robot wheels to these inputs were examined. Circular movements were made to the robot with a range of velocity input values and the relationship between input and output was examined for both wheels of the robot. In the locomotion tests, it was observed that the robot completed the predetermined routes with minor errors. As a result of these tests, theoretical calculations and experimental results were compared and the reasons for the error parameters were discussed. Through system identification tests, it was observed that the right wheel of the robot was more consistent and produced closer to the expected value for each test performed.
Effect of transformational behavior on millennial job satisfaction
Authors: Valldeneu Marc , Ferràs Xavier , Tarrats Elisenda
Published: September 2021

Leaders are responsible for empowering and driving employees to succeed in challenging times or changes and, ultimately, achieve the best results. One of the biggest dilemmas in today’s leaders’ agenda is to understand how to manage a diverse multigenerational workforce in which millennials represent a predominant group by far, being completely different from previous generations due to the technology impact. The aim of the paper is to identify which leadership style and behavior affects most positively millennial job satisfaction in a multinational environment, and to understand the differences between millennials and non-millennials. The Multifactor Leadership Questionnaire, known as the MLQ, was answered by 167 representative employees from various multinational corporations, 125 of whom are millennials. Based on the results, transformational style is strongly correlated with and positively affected by millennial job satisfaction. Moreover, transformational style is a significant predictor of increased millennial satisfaction, and more specifically, idealized attributes and intellectual stimulation are behaviors that have been validated to increase it. On the other hand, individual consideration has been proven to have a productive effect by increasing non-millennial job satisfaction. According to the findings, millennial workforce leaders need to move towards a more transformational style, based on more idealized attributes and an intellectual stimulation approach, if they want to increase their satisfaction and avoid unwanted attrition. Basically, millennials are searching for leaders who trust and embrace innovation, creativity, critical thinking and, most importantly, leaders who also question the status quo.
BILIARY PAH METABOLITES IN FISH FROM THE HIGHLY IMPACTED GUANABARA BAY, IN SOUTHEASTERN BRAZIL, DETERMINED BY FIXED AND SYNCHRONOUS FLUORESCENCE SPECTROSCOPY
Authors: Freire Marina , Gómez Cristina , Oliveira Anabela , Moreira Josino , Arias Ana
Published: September 2021

Guanabara Bay (GB) covers the metropolitan region of the state of Rio de Janeiro in Brazil. GB is subject to heavy contamination by polycyclic aromatic hydrocarbons (PAHs), from intense oil activities, which pose an ecotoxicological threat. The aim of this study is to implement and optimize a fluorescence methodology for the determination of biliary PAH metabolites in fish species (burrfish and whitemouth croaker), in order to evaluate biliary PAH metabolites as a biomarker of exposure. Fish were sampled from GB and a control region. Naphthalene, pyrene and benzo(a)pyrene metabolites were determined by Fixed Fluorescence Method (FF), while 1-hydroxypyrene was assessed by Synchronous Fluorescence Spectroscopy (SFS). The implementation and optimization of the FF and SFS methods allowed the determination and evaluation of the exposure of these species to PAHs of pyrogenic and petrogenic origin. Biliary PAH metabolite determinations was proven to be a useful tool for environmental monitoring contamination assessments.
OTIMIZAÇÃO DA EXTRAÇÃO DE ANTOCIANINAS PRESENTES NO FEIJÃO-PRETO E IMPREGNAÇÃO DO EXTRATO EM MATRIZ POLIMÉRICA NATURAL PARA USO COMO INDICADOR DE pH
Authors: Nunes Chalder , Jansen Aline , Quináia Sueli
Published: September 2021

OPTIMIZATION OF THE EXTRACTION OF ANTHOCYANINS PRESENT IN BLACK BEANS AND IMPREGNATION OF THE EXTRACT IN NATURAL POLYMERIC MATRIX FOR USE AS A pH INDICATOR. In this work, a method of extracting natural indicators, anthocyanins, present in black beans was optimized. The best extraction condition was obtained with 50 g of beans and 93 g of water, under agitation at 150 rpm, at a temperature of 40 oC for 24 h. The wavelengths of greatest absorption for the indicator in its acidic and basic form were 523 nm and 620 nm respectively and these wavelengths were used to determine the pKa of the indicator. At least three pKa values were observed: 1.9; 7.2 and 10.7. A simplified condition for anthocyanins extraction, the same amount of water, tap water in these case, and beans kept together for 12 h without agitation and temperature control, was also evaluated. Both extracts were impregnated with qualitative filter paper, coffee filter paper and cotton buds and the materials impregnated with the indicator were tested with solutions of HCl, vinegar, NaOH and milk of magnesia. A comparison between the impregnated material and a universal pH indicator paper using buffer solutions pH 4.0, 7.0, 10.0 and 11.2 proved the applicability of the developed material since it presented adequate distinction in its color for the different pH conditions.
Comparison between two generalized Nash models with a same non-zero initial condition
Authors: Yan Baowei , Liu Yu , Li Zhengkun , Jiang Huining
Published: September 2021

Initial condition can impact the forecast precision especially in a real-time forecasting stage. The discrete linear cascade model (DLCM) and the generalized Nash model (GNM), though expressed in different ways, are both the generalization of the Nash cascade model considering the initial condition. This paper investigates the relationship and difference between DLCM and GNM both mathematically and experimentally. Mathematically, the main difference lies in the way to estimate the initial storage state. In the DLCM, the initial state is estimated and not unique, while that in the GNM is observed and unique. Hence, the GNM is the exact solution of the Nash cascade model, while the DLCM is an approximate solution and it can be transformed to the GNM when the initial storage state is calculated by the approach suggested in the GNM. As a discrete solution, the DLCM can be directly applied to the practical discrete streamflow data system. However, the numerical calculation approach such as the finite difference method is often used to make the GNM practically applicable. Finally, a test example obtained by the solution of the Saint-Venant equations is used to illustrate this difference. The results show that the GNM provides a unique solution while the DLCM has multiple solutions, whose forecast precision depends upon the estimate accuracy of the current state.