bluuebunny/crossref_metadata_2025 huggingface dataset:
Vesuvianite from the Somma-Vesuvius Complex: New Data and Revised Formula
Authors: Panikorovskii Taras , Chukanov Nikita , Rusakov Vyacheslav , Shilovskikh Vladimir , Mazur Anton , Balassone Giuseppina , Ivanyuk Gregory , Krivovichev Sergey
Published: December 2017

At present, the vesuvianite group of minerals consists of eight members, six of which are distinguished by the dominant cation in the Y1(A,B) five-coordinated site. We investigated two vesuvianite samples from the type locality by electron microprobe analysis, Mössbauer and infrared spectroscopy, TGA/DSC, MAS NMR, single-crystal and powder X-ray diffraction. The crystal structures of these samples (# 27844 and 51062 from the Vesuvius collection, Fersman Mineralogical Museum, Moscow) have been refined to R1 = 0.027 and R1 = 0.035, respectively. Both samples have the space group P4/nnc; a = 15.5720(3) and 15.5459(3), c = 11.8158(5) and 11.7988(4), respectively. In both samples low-occupied T1 and T2 sites are populated by minor B and Al, which agrees with their high-temperature origin. According to our experimental results, the general revised crystal-chemical formula of vesuvianite can be written as VII−IXX19VY1VIY12(Z2O7)4(ZO4)10(W)10, where X are seven- to nine-coordinated sites of Ca with minor Na, K, Fe2+ and REE impurities; VY has a square pyramidal coordination and is occupied predominantly by Fe3+ with subordinate Mg, Al, Fe2+ and Cu2+; VIY has octahedral coordination and is predominantly occupied by Al with subordinate Mg, Fe2+, Fe3+, Mn2+, Mn3+, Ti, Cr and Zn; ZO4 = SiO4, sometimes with subordinate AlO4 and/or (OH)4, and W = OH, F, with minor O and Cl. The idealized charge-balanced formula of the vesuvianite end-member without subordinate cations is Ca19Fe3+(Al10Me2+2)(Si2O7)4(SiO4)10O(OH)9, where Ме = Fe2+, Mg2+, Mn2+.
Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex
Authors: Davaatseren Munkhtugs , Jo Yeon-Ji , Hong Geun-Pyo , Hur Haeng , Park Sujin , Choi Mi-Jung
Published: December 2017

trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.
Bioremediation of Synthetic and Industrial Effluents by Aspergillus niger Isolated from Contaminated Soil Following a Sequential Strategy
Authors: Gulzar Tahsin , Huma Tayyaba , Jalal Fatima , Iqbal Sarosh , Abrar Shazia , Kiran Shumaila , Nosheen Sofia , Hussain Waqar , Rafique Muhammad
Published: December 2017

The present study aimed to assess and compare the ability to remediate synthetic textile and industrial wastewaters by Fenton treatment, a biological system and sequential treatments using Aspergillus niger (A. niger). All studied treatments were found to be effective in decolorization of the effluents under study. Fenton treatment followed by A. niger showed excellent potential for the maximum decolorization of the synthetic and industrial effluents under study. The effectiveness of sequential treatment was evaluated by water quality parameters such as total organic carbon (TOC), Biological Oxygen Demand (BOD5) and Chemical Oxygen Demand (COD) before and after each treatment. The results indicated that A. niger is an effective candidate for detoxification of textile wastewaters.
Identification of the Sex-Biased Gene Expression and Putative Sex-Associated Genes in Eucommia ulmoides Oliver Using Comparative Transcriptome Analyses
Authors: Wang Wencai , Zhang Xianzhi
Published: December 2017

Eucommia ulmoides is a model representative of the dioecious plants with sex differentiation at initiation. Nevertheless, the genetic mechanisms of sexual dimorphism and sex determination in E. ulmoides remain poorly understood. In this study de novo transcriptome sequencing on Illumina platform generated >45 billion high-quality bases from fresh leaves of six male and female individuals of E. ulmoides. A total of 148,595 unigenes with an average length of 801 base-pairs (bp) were assembled. Through comparative transcriptome analyses, 116 differentially expressed genes (DEGs) between the males and the females were detected, including 73 male-biased genes and 43 female-biased genes. Of these DEGs, three female-biased genes were annotated to be related with the sexually dimorphic gutta content in E. ulmoides. One male-biased DEG was identified as putative MADS box gene APETALA3, a B class floral organ identity gene in the flowering plants. SNPs calling analyses further confirmed that the APETALA3-like gene was probably involved in the sex determination in E. ulmoides. Four other male-biased DEGs were potential sex-associated genes as well with segregated SNPs in accord with sex type. In addition, the SNPs density was 1.02 per kilobase (kb) in the expressed genes of E. ulmoides, implying a relatively high genetic diversity.
Pathogenic Acanthamoeba castellanii Secretes the Extracellular Aminopeptidase M20/M25/M40 Family Protein to Target Cells for Phagocytosis by Disruption
Authors: Huang Jian-Ming , Liao Chen-Chieh , Kuo Chung-Ching , Chen Lih-Ren , Huang Lynn , Shin Jyh-Wei , Lin Wei-Chen
Published: December 2017

Acanthamoeba is free-living protist pathogen capable of causing a blinding keratitis and granulomatous encephalitis. However, the mechanisms of Acanthamoeba pathogenesis are still not clear. Here, our results show that cells co-cultured with pathogenic Acanthamoeba would be spherical and floated, even without contacting the protists. Then, the Acanthamoeba protists would contact and engulf these cells. In order to clarify the contact-independent pathogenesis mechanism in Acanthamoeba, we collected the Acanthamoeba-secreted proteins (Asp) to incubate with cells for identifying the extracellular virulent factors and investigating the cytotoxicity process. The Asps of pathogenic Acanthamoeba express protease activity to reactive Leu amino acid in ECM and induce cell-losing adhesion ability. The M20/M25/M40 superfamily aminopeptidase protein (ACA1_264610), an aminopeptidase be found in Asp, is upregulated after Acanthamoeba and C6 cell co-culturing for 6 h. Pre-treating the Asp with leucine aminopeptidase inhibitor and the specific antibodies of Acanthamoeba M20/M25/M40 superfamily aminopeptidase could reduce the cell damage during Asp and cell co-incubation. These results suggest an important functional role of the Acanthamoeba secreted extracellular aminopeptidases in the Acanthamoeba pathogenesis process. This study provides information regarding clinically pathogenic isolates to target specific molecules and design combined drugs.
Vanadium Compounds as PTP Inhibitors
Authors: Irving Elsa , Stoker Andrew
Published: December 2017

Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We describe how vanadate in the V oxidized state is thought to inhibit PTPs, thus acting as a pan-inhibitor of this enzyme superfamily. We discuss recent developments in the biological and biochemical actions of more complex vanadium derivatives, including decavanadate and in particular the growing number of oxidovanadium compounds with organic ligands. Pre-clinical studies involving these compounds are discussed in the anti-diabetic and anti-cancer contexts. Although in many cases PTP inhibition has been implicated, it is also clear that many such compounds have further biochemical effects in cells. There also remain concerns surrounding off-target toxicities and long-term use of vanadium compounds in vivo in humans, hindering their progress through clinical trials. Despite these current misgivings, interest in these chemicals continues and many believe they could still have therapeutic potential. If so, we argue that this field would benefit from greater focus on improving the delivery and tissue targeting of vanadium compounds in order to minimize off-target toxicities. This may then harness their full therapeutic potential.
The Dual Antioxidant/Prooxidant Effect of Eugenol and Its Action in Cancer Development and Treatment
Authors: Bezerra Daniel , Militão Gardenia , De Morais Mayara , De Sousa Damião
Published: December 2017

The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products. Eugenol has a dual effect on oxidative stress, which can action as an antioxidant or prooxidant agent. In addition, it has anti-carcinogenic, cytotoxic and antitumor properties. Considering the importance of eugenol in the area of food and human health, in this review, we discuss the role of eugenol on redox status and its potential use in the treatment and prevention of cancer.
Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin
Authors: Rojo de la Vega Montserrat , Krajisnik Andrea , Zhang Donna , Wondrak Georg
Published: December 2017

The transcription factor NRF2 (nuclear factor-E2-related factor 2) orchestrates major cellular defense mechanisms including phase-II detoxification, inflammatory signaling, DNA repair, and antioxidant response. Recent studies strongly suggest a protective role of NRF2-mediated gene expression in the suppression of cutaneous photodamage induced by solar UV (ultraviolet) radiation. The apocarotenoid bixin, a Food and Drug Administration (FDA)-approved natural food colorant (referred to as ‘annatto’) originates from the seeds of the achiote tree native to tropical America, consumed by humans since ancient times. Use of achiote preparations for skin protection against environmental insult and for enhanced wound healing has long been documented. We have recently reported that (i) bixin is a potent canonical activator of the NRF2-dependent cytoprotective response in human skin keratinocytes; that (ii) systemic administration of bixin activates NRF2 with protective effects against solar UV-induced skin damage; and that (iii) bixin-induced suppression of photodamage is observable in Nrf2+/+ but not in Nrf2−/− SKH-1 mice confirming the NRF2-dependence of bixin-induced antioxidant and anti-inflammatory effects. In addition, bixin displays molecular activities as sacrificial antioxidant, excited state quencher, PPAR (peroxisome proliferator-activated receptor) α/γ agonist, and TLR (Toll-like receptor) 4/NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells) antagonist, all of which might be relevant to the enhancement of skin barrier function and environmental stress protection. Potential skin photoprotection and photochemoprevention benefits provided by topical application or dietary consumption of this ethno-pharmacologically validated phytochemical originating from the Americas deserves further preclinical and clinical examination.
Multi-Omic Biogeography of the Gastrointestinal Microbiota of a Pre-Weaned Lamb
Authors: Palomba Antonio , Tanca Alessandro , Fraumene Cristina , Abbondio Marcello , Fancello Francesco , Atzori Alberto , Uzzau Sergio
Published: December 2017

The digestive functions of the pre-weaned lamb gastrointestinal tracts (GITs) have been the subject of much research in recent years, but the microbial and host functions underlying these complex processes remain largely unknown. Here, we undertook a proof-of-principle metaproteogenomic investigation on luminal and mucosal samples collected from 10 GITs of a 30-day-old pre-weaned lamb. We demonstrate that the analysis of the diverse ecological niches along the GITs can reveal microbiota composition and metabolic functions, although low amounts of microbial proteins could be identified in the small intestinal and mucosal samples. Our data suggest that a 30-day lamb has already developed mature microbial functions in the forestomachs, while the effect of the milky diet appears to be more evident in the remaining GITs. We also report the distribution and the relative abundance of the host functions, active at the GIT level, with a special focus on those involved in digestive processes. In conclusion, this pilot study supports the suitability of a metaproteogenomic approach to the characterization of microbial and host functions of the lamb GITs, opening the way to further studies aimed at investigating the impact of early dietary interventions on the GIT microbiota of small ruminants.
Stable Weak Approximation at Work in Index-Linked Catastrophe Bond Pricing
Authors: Burnecki Krzysztof , Giuricich Mario
Published: December 2017

We consider the subject of approximating tail probabilities in the general compound renewal process framework, where severity data are assumed to follow a heavy-tailed law (in that only the first moment is assumed to exist). By using the weak convergence of compound renewal processes to α -stable Lévy motion, we derive such weak approximations. Their applicability is then highlighted in the context of an existing, classical, index-linked catastrophe bond pricing model, and in doing so, we specialize these approximations to the case of a compound time-inhomogeneous Poisson process. We emphasize a unique feature of our approximation, in that it only demands finiteness of the first moment of the aggregate loss processes. Finally, a numerical illustration is presented. The behavior of our approximations is compared to both Monte Carlo simulations and first-order single risk loss process approximations and compares favorably.
MODIS Sea Ice Thickness and Open Water–Sea Ice Charts over the Barents and Kara Seas for Development and Validation of Sea Ice Products from Microwave Sensor Data
Authors: Mäkynen Marko , Karvonen Juha
Published: December 2017

We have developed algorithms and procedures for calculating daily sea ice thickness (SIT) and open water–sea ice (OWSI) charts, based on the Moderate Resolution Imaging Spectroradiometer (MODIS), ice surface temperature (IST) (night-time only), and reflectance ( R ) swath data, respectively. The resolution of the SIT chart is 1 km and that of the OWSI chart is 250 m. The charts are targeted to be used in development and validation of sea ice products from microwave sensor data. We improve the original MODIS cloud masks for the IST and R data, with a focus on identifying larger cloud-free areas in the data. The SIT estimation from the MODIS IST swath data follows previous studies. The daily SIT chart is composed from available swath charts by assigning daily median SIT to a pixel. The OWSI classification is simply conducted by a fixed threshold for the MODIS band 1 R . This was based on manually selected R data for various ice types in late winter, early melt, and advanced melt conditions. The composition procedures for the daily SIT and OWSI charts somewhat compensates for errors due to the undetected clouds. The SIT and OWSI charts were compared against manual ice charts by Arctic and Antarctic Research Institute in Russia and by Norwegian Meteorological Institute, respectively, and on average, a good relationship between the charts was found. Pixel-wise comparison of the SIT and OWSI charts showed very good agreement in open water vs. sea ice classification, which gives further confidence on the reliability of our algorithms. We also demonstrate usage of the MODIS OWSI and SIT charts for validation of sea ice concentration charts based on the SENTINEL-1 SAR and AMSR2 radiometer data and two different algorithms.
A Quantum Hybrid PSO Combined with Fuzzy k-NN Approach to Feature Selection and Cell Classification in Cervical Cancer Detection
Authors: Iliyasu Abdullah , Fatichah Chastine
Published: December 2017

A quantum hybrid (QH) intelligent approach that blends the adaptive search capability of the quantum-behaved particle swarm optimisation (QPSO) method with the intuitionistic rationality of traditional fuzzy k-nearest neighbours (Fuzzy k-NN) algorithm (known simply as the Q-Fuzzy approach) is proposed for efficient feature selection and classification of cells in cervical smeared (CS) images. From an initial multitude of 17 features describing the geometry, colour, and texture of the CS images, the QPSO stage of our proposed technique is used to select the best subset features (i.e., global best particles) that represent a pruned down collection of seven features. Using a dataset of almost 1000 images, performance evaluation of our proposed Q-Fuzzy approach assesses the impact of our feature selection on classification accuracy by way of three experimental scenarios that are compared alongside two other approaches: the All-features (i.e., classification without prior feature selection) and another hybrid technique combining the standard PSO algorithm with the Fuzzy k-NN technique (P-Fuzzy approach). In the first and second scenarios, we further divided the assessment criteria in terms of classification accuracy based on the choice of best features and those in terms of the different categories of the cervical cells. In the third scenario, we introduced new QH hybrid techniques, i.e., QPSO combined with other supervised learning methods, and compared the classification accuracy alongside our proposed Q-Fuzzy approach. Furthermore, we employed statistical approaches to establish qualitative agreement with regards to the feature selection in the experimental scenarios 1 and 3. The synergy between the QPSO and Fuzzy k-NN in the proposed Q-Fuzzy approach improves classification accuracy as manifest in the reduction in number cell features, which is crucial for effective cervical cancer detection and diagnosis.
Condition Assessment of Foundation Piles and Utility Poles Based on Guided Wave Propagation Using a Network of Tactile Transducers and Support Vector Machines
Authors: Dackermann Ulrike , Yu Yang , Niederleithinger Ernst , Li Jianchun , Wiggenhauser Herbert
Published: December 2017

This paper presents a novel non-destructive testing and health monitoring system using a network of tactile transducers and accelerometers for the condition assessment and damage classification of foundation piles and utility poles. While in traditional pile integrity testing an impact hammer with broadband frequency excitation is typically used, the proposed testing system utilizes an innovative excitation system based on a network of tactile transducers to induce controlled narrow-band frequency stress waves. Thereby, the simultaneous excitation of multiple stress wave types and modes is avoided (or at least reduced), and targeted wave forms can be generated. The new testing system enables the testing and monitoring of foundation piles and utility poles where the top is inaccessible, making the new testing system suitable, for example, for the condition assessment of pile structures with obstructed heads and of poles with live wires. For system validation, the new system was experimentally tested on nine timber and concrete poles that were inflicted with several types of damage. The tactile transducers were excited with continuous sine wave signals of 1 kHz frequency. Support vector machines were employed together with advanced signal processing algorithms to distinguish recorded stress wave signals from pole structures with different types of damage. The results show that using fast Fourier transform signals, combined with principal component analysis as the input feature vector for support vector machine (SVM) classifiers with different kernel functions, can achieve damage classification with accuracies of 92.5% ± 7.5%.
Sensitivity Analysis of Different Shapes of a Plastic Optical Fiber-Based Immunosensor for Escherichia coli: Simulation and Experimental Results
Authors: Rodrigues Domingos , Lopes Rafaela , Franco Marcos , Werneck Marcelo , Allil Regina
Published: December 2017

Conventional pathogen detection methods require trained personnel, specialized laboratories and can take days to provide a result. Thus, portable biosensors with rapid detection response are vital for the current needs for in-loco quality assays. In this work the authors analyze the characteristics of an immunosensor based on the evanescent field in plastic optical fibers with macro curvature by comparing experimental with simulated results. The work studies different shapes of evanescent-wave based fiber optic sensors, adopting a computational modeling to evaluate the probes with the best sensitivity. The simulation showed that for a U-Shaped sensor, the best results can be achieved with a sensor of 980 µm diameter by 5.0 mm in curvature for refractive index sensing, whereas the meander-shaped sensor with 250 μm in diameter with radius of curvature of 1.5 mm, showed better sensitivity for either bacteria and refractive index (RI) sensing. Then, an immunosensor was developed, firstly to measure refractive index and after that, functionalized to detect Escherichia coli. Based on the results with the simulation, we conducted studies with a real sensor for RI measurements and for Escherichia coli detection aiming to establish the best diameter and curvature radius in order to obtain an optimized sensor. On comparing the experimental results with predictions made from the modelling, good agreements were obtained. The simulations performed allowed the evaluation of new geometric configurations of biosensors that can be easily constructed and that promise improved sensitivity.
Blind Compensation of I/Q Impairments in Wireless Transceivers
Authors: Aziz Mohsin , Ghannouchi Fadhel , Helaoui Mohamed
Published: December 2017

The majority of techniques that deal with the mitigation of in-phase and quadrature-phase (I/Q) imbalance at the transmitter (pre-compensation) require long training sequences, reducing the throughput of the system. These techniques also require a feedback path, which adds more complexity and cost to the transmitter architecture. Blind estimation techniques are attractive for avoiding the use of long training sequences. In this paper, we propose a blind frequency-independent I/Q imbalance compensation method based on the maximum likelihood (ML) estimation of the imbalance parameters of a transceiver. A closed-form joint probability density function (PDF) for the imbalanced I and Q signals is derived and validated. ML estimation is then used to estimate the imbalance parameters using the derived joint PDF of the output I and Q signals. Various figures of merit have been used to evaluate the efficacy of the proposed approach using extensive computer simulations and measurements. Additionally, the bit error rate curves show the effectiveness of the proposed method in the presence of the wireless channel and Additive White Gaussian Noise. Real-world experimental results show an image rejection of greater than 30 dB as compared to the uncompensated system. This method has also been found to be robust in the presence of practical system impairments, such as time and phase delay mismatches.
From Differentiation to Concretisation: Integrative Experiments in Sustainable Architecture
Authors: Farmer Graham
Published: December 2017

It is widely recognised that the achievement of a sustainable built environment requires holistic design practices and approaches that are capable of balancing the varied, and often conflicting, demands of environmental, social and economic concerns. However, academics and practitioners have recently highlighted, and expressed concerns about the knowledge gap that currently exists within environmental policy, research and practice between understandings of the technical performance of buildings and their social meaning and relevance. This paper acknowledges these concerns and is developed from the author’s own direct experiences of practice-led research and active participation in design-build projects. It argues for a theoretically-informed and socially-engaged approach to built environment research, pedagogy and practice that seeks to encourage an integrative understanding of the design, realisation and use of sustainable architecture. The paper draws on the Philosophy of Technology and in particular the work of Andrew Feenberg to analyse the buildings and to propose an integrated and inclusive framework for understanding sustainable design that acknowledges not just what the built environment does, but also what it means. It also suggests that what a building means also informs what it can do, and for whom. Although the technical and social dimensions of design can be interpreted as distinct practices and are often institutionally separated, this paper argues that the realisation of sustainable design must seek a conscious interaction and interchange between these two differentiated dimensions.
Academic Advising and Maintaining Major: Is There a Relation?
Authors: Jaradat Maram S. , Mustafa Mohammad B.
Published: December 2017

The purpose of this study is to investigate the effect of academic advising on changing or maintaining majors in university degrees. It is also a goal of the study to determine which semester students change their majors and whether advising contributes to that change. Through this correlational study, the researchers explored students’ perceptions about the academic advising they received and the relationship of its absence on students’ major change. The participants were 1725 undergraduate students from all year levels. The survey used to collect the data for this study is: the Influences on Choice of Major survey. Based on the findings, it was found that university advisors have a very poor effect on students’ decisions to select their majors as 45.6% of the 1725 participants indicated no influence of advising in their survey answers. Whereas career advancement opportunities, students’ interests, and job opportunities indicate a strong effect on their majors’ selections, as they score the highest means of 3.76, 3.73, and 3.64, respectively. In addition, findings show that students are most likely changing their majors in their second year, and specifically in the second semester. Second year major change scored 36.9% in the second semester and 30.9% in the first semester. More importantly, results indicate that there is a positive significant correlation between college advisors and major change in the second year (p = 0.000). It is to researchers’ understanding based on the findings that when students receive enough academic advising in the first year of study, and this advising continues steadily into the next year, the probability of students changing their majors decreases greatly.
A Global Review of Sustainable Construction Project Financing: Policies, Practices, and Research Efforts
Authors: Shan Ming , Hwang Bon-Gang , Zhu Lei
Published: December 2017

Despite the increasing investment in sustainable development over the past decade, a systematic review of sustainable construction project financing is lacking. The objectives of this paper are to conduct a systematic review to examine the policies, practices, and research efforts in the area of sustainable construction project financing, and to explore the potential opportunities for the future research. To achieve these goals, this paper first reviewed the sustainable construction project financing practices implemented by four representative developed economies including the United Kingdom, the United States, Singapore, and Australia. Then, this paper reviewed the efforts and initiatives launched by three international organizations including the United Nations, the Organization for Economic Co-operation and Development, and International Finance Corporation. After that, this paper reviewed the research efforts of sustainable construction project financing published in peer-review journals and books. This paper identified four major research themes within this area, which are the review of financial stakeholders and market of sustainable construction, benefits and barriers to sustainable construction project financing, financial vehicles for sustainable construction projects, innovative models and mechanisms for sustainable construction project financing. Additionally, this paper revealed five directions for the future research of sustainable construction project financing, which are the identification of financial issues in sustainable construction projects, the investigation of financial vehicles for sustainable construction projects in terms of their strengths, limitations, and performances, the examination of critical drivers for implementing sustainable construction project financing, the development of a knowledge-based decision support system for implementing sustainable construction financing, and the development of best practices for implementing sustainable construction project financing. This paper contributes to the body of knowledge by reviewing existing policies, practices, and research efforts in the area of sustainable construction project financing. Meanwhile, the findings from this paper benefit the industry as well, because they are able to provide the practitioners with a holistic view of sustainable construction project financing, thereby enhancing their knowledge and skills in this regard.
Pricing Policies in Green Supply Chains with Vertical and Horizontal Competition
Authors: Chen Shan , Wang Xu , Ni Lin , Wu Yingbo
Published: December 2017

The paper explores the pricing policies and green strategies in a duopoly green supply chain with vertical and horizontal competition, which includes a green manufacturer, a traditional manufacturer and a common retailer. The purpose of the paper is to address the following research problems: (1) How manufacturers’ market power influences the pricing policies and green strategies of supply chain members in a green supply chain? (2) What conditions do first-mover advantage and green competitive advantage be effective simultaneously? We establish the linear demand functions of the duopoly green supply chain and obtain the players’ optimal decisions under channel members’ different market power. Further, we conduct sensitivity analysis and numerical examples of players’ optimal decisions about consumer’s environmental awareness and greening cost effector. Based on the theoretical and numerical analysis, we find that green manufacturer would benefit from the increment of consumer’s environmental awareness but be depressed by the increase of greening cost, which is contrary to the traditional manufacturer. Additionally, correlations of retailer’ optimal decisions and profits between consumer’s environmental awareness and greening cost effector are related to the manufacturers’ market power structures. Furthermore, we find that the green competitive advantage is more effective than first-mover advantage while first-mover advantage does not always effective in the duopoly green supply chain. Specially, traditional manufacturer always prefers to be the follower competing with the green manufacturer, no matter with the variety of consumer’s environmental awareness and greening cost effector, while green manufacturer would like to be the leader only when the consumer’s environmental awareness is relatively high or the greening cost effector is relatively low.
Promoting Profit Model Innovation in Animation Project in Northeast Asia: Case Study on Chinese Cultural and Creative Industry
Authors: Jiao Hao , Wang Yupei , Xiao Hongjun , Zhou Jianghua , Zeng Wensi
Published: December 2017

Building on a case study of three animation companies in the Chinese cultural and creative industry, this study aims to understand how profit model innovation is promoted. Due to the rapidly changing environments and resource scarcity, cultural and creative companies need to select the appropriate profit model according to their own key resources. The study uncovers two critical factors that promote profit model innovation in animation projects: the quantity of consumers and their consumption intention. According to these two dimensions, the authors’ analysis shows profit model innovation in animation projects can be divided into Fans mode, Popular mode, Placement mode, and Failure mode, respectively. This study provides an empirical basis for advocating profit model innovation and discusses the resource requirements of Fan mode, Popular model, and Placement mode in China’s cultural and creative industry. The authors’ research also has managerial implications that might help firms promote profit model innovation. Finally, learning and promoting the profit model of China’s animation industry in the Northeast Asia area will be conducive to Northeast Asia’s cooperation and sustainable development.
China’s Land Resources Dilemma: Problems, Outcomes, and Options for Sustainable Land Restoration
Authors: Zhang Lulu , Schwärzel Kai
Published: December 2017

Pressing issues such as water and food security, health, peace, and poverty are deeply linked to land degradation. We use China’s major land restoration programs as a case offering perspective on the existing problems in China’s major policies for improving degraded land and maintaining land resources in three dimensions. The shortcomings and outcomes in terms of biophysical consequences, socioeconomic benefits, and political goals are addressed, namely (i) non-integrated land resources management creates new problems while solving existing problems, (ii) non-participatory processes and “one-size-fits-all” measures compromise socioeconomic benefits, and (iii) implementation outcomes conflict with policy targets for sustainable land management and development. Based on discussions for more sustainable land management, we conclude that China needs to create a new mode of ‘economy and environment’ in plans and actions of restoring degraded land resources. Establishing multifunctional land-use systems based on formulating and balancing multiple benefits/services across socio-ecological sectors can be an option to achieve such a mode. At the end, recommendations are given for research and implementation that are not only vital for China but also relevant for other regions since the challenges of afforestation and sustainable land development faced in China are not unique.
A Novel Grey Wave Method for Predicting Total Chinese Trade Volume
Authors: Yin Kedong , Lu Danning , Li Xuemei
Published: December 2017

The total trade volume of a country is an important way of appraising its international trade situation. A prediction based on trade volume will help enterprises arrange production efficiently and promote the sustainability of the international trade. Because the total Chinese trade volume fluctuates over time, this paper proposes a Grey wave forecasting model with a Hodrick–Prescott filter (HP filter) to forecast it. This novel model first parses time series into long-term trend and short-term cycle. Second, the model uses a general GM (1,1) to predict the trend term and the Grey wave forecasting model to predict the cycle term. Empirical analysis shows that the improved Grey wave prediction method provides a much more accurate forecast than the basic Grey wave prediction method, achieving better prediction results than autoregressive moving average model (ARMA).
Production and Compression Strength of Mortars Containing Unprocessed Waste Powdered Steel Slag
Authors: Maschio Stefano , Aneggi Eleonora , Fedrizzi Lorenzo , Andreatta Francesco , Lekka Maria , Lanzutti Alex , Furlani Erika
Published: December 2017

This paper deals with the production of mortars prepared using a commercial CEMIIB-S 42.5N cement, a natural aggregate, steelmaking slag, a superplasticizer and water. The as-received unprocessed steel slag was milled by a hammer mill and then sieved to obtain batches with different maximum particle size. Each batch was used, together with the other components, in the production of mortars which were tested, by compression and water absorption, after different aging times in order to evaluate their long term stability. Several slag-free samples were also prepared as reference materials. All mortars were prepared with fixed aggregate/cement ratio (6/1), superplasticizer/cement ratio (s/c) and water/cement ratio (w/c). It has been demonstrated that an adequate protocol for the preparation and the use of slag containing particles with 2500 µm maximum size lead to the production of materials with mechanical properties suitable for civil engineering applications after aging for 28, 90 and 180 days. However, samples containing slag particles with size equal or greater than 1000 µm display a decay of mechanical properties after longer aging in water or after accelerated aging.
Does Social Innovation Contribute to Sustainability? The Case of Italian Innovative Start-Ups
Authors: Piccarozzi Michela
Published: December 2017

Start-ups, among other enterprises, play a major role in the development and/or commercialization of new technologies and the development of national economies, given that firms are the innovation locus for an entire society. In Italy, a recent regulatory intervention has focused on start-ups creating a framework where innovative start-ups are defined and regulated. Among innovative start-ups, those with a social vocation are of particular interest, since they are understudied in the literature. Indeed, the aim of this paper is twofold: to analyze the relationship between social innovation and sustainability in the latter businesses, and try to understand how sustainability could be fostered through them. Italian cases of innovative start-ups will be studied through content analysis applied to the Social Impact Assessment Document provided by firms. Results show that the Social Impact Assessment Document provided by innovative start-ups explicitly pays attention to social innovation and sustainability in different ways. However, the document does not show the link between social innovation and sustainability. Nonetheless, going through these documents, the link between social innovation and the three aspects of sustainability (economic, social and environmental) clearly emerge and therefore could be better managed.
New Applications of m-Polar Fuzzy Matroids
Authors: Sarwar Musavarah , Akram Muhammad
Published: December 2017

Mathematical modelling is an important aspect in apprehending discrete and continuous physical systems. Multipolar uncertainty in data and information incorporates a significant role in various abstract and applied mathematical modelling and decision analysis. Graphical and algebraic models can be studied more precisely when multiple linguistic properties are dealt with, emphasizing the need for a multi-index, multi-object, multi-agent, multi-attribute and multi-polar mathematical approach. An m-polar fuzzy set is introduced to overcome the limitations entailed in single-valued and two-valued uncertainty. Our aim in this research study is to apply the powerful methodology of m-polar fuzzy sets to generalize the theory of matroids. We introduce the notion of m-polar fuzzy matroids and investigate certain properties of various types of m-polar fuzzy matroids. Moreover, we apply the notion of the m-polar fuzzy matroid to graph theory and linear algebra. We present m-polar fuzzy circuits, closures of m-polar fuzzy matroids and put special emphasis on m-polar fuzzy rank functions. Finally, we also describe certain applications of m-polar fuzzy matroids in decision support systems, ordering of machines and network analysis.
High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans
Authors: Carle Stefan , Pirazzini Marco , Rossetto Ornella , Barth Holger , Montecucco Cesare
Published: December 2017

The Genome Aggregation Database presently contains >120,000 human genomes. We searched in this database for the presence of mutations at the sites of tetanus (TeNT) and botulinum neurotoxins (BoNTs) cleavages of the three SNARE proteins: VAMP, SNAP-25 and Syntaxin. These mutations could account for some of the BoNT/A resistant patients. At the same time, this approach was aimed at testing the possibility that TeNT and BoNT may have acted as selective agents in the development of resistance to tetanus or botulism. We found that mutations of the SNARE proteins are very rare and concentrated outside the SNARE motif required for the formation of the SNARE complex involved in neuroexocytosis. No changes were found at the BoNT cleavage sites of VAMP and syntaxins and only one very rare mutation was found in the essential C-terminus region of SNAP-25, where Arg198 was replaced with a Cys residue. This is the P1’ cleavage site for BoNT/A and the P1 cleavage site for BoNT/C. We found that the Arg198Cys mutation renders SNAP-25 resistant to BoNT/A. Nonetheless, its low frequency (1.8 × 10−5) indicates that mutations of SNAP-25 at the BoNT/A cleavage site are unlikely to account for the existence of BoNT/A resistant patients. More in general, the present findings indicate that tetanus and botulinum neurotoxins have not acted as selective agents during human evolution as it appears to have been the case for tetanus in rats and chicken.
Rickettsia felis: A Review of Transmission Mechanisms of an Emerging Pathogen
Authors: Legendre Kelsey , Macaluso Kevin
Published: December 2017

Rickettsia felis is an emerging pathogen of the transitional group of Rickettsia species and an important cause of febrile illness in Africa. Since the organism’s original discovery in the early 1990s, much research has been directed towards elucidating transmission mechanisms within the primary host and reservoir, the cat flea (Ctenocephalides felis). Several mechanisms for vertical and horizontal transmission within this vector have been thoroughly described, as well as transmission to other arthropod vectors, including other species of fleas. However, while a growing number of human cases of flea-borne spotted fever are being reported throughout the world, a definitive transmission mechanism from arthropod host to vertebrate host resulting in disease has not been found. Several possible mechanisms, including bite of infected arthropods and association with infectious arthropod feces, are currently being investigated.
Lévy Femtoscopy with PHENIX at RHIC
Authors: Csanád Máté
Published: December 2017

In this paper we present the measurement of charged pion two-particle femtoscopic correlation functions in s N N = 200 GeV Au + Au collisions in 31 average transverse mass bins, separately for positive and negative pion pairs. Lévy-shaped source distributions yield a statistically acceptable description of the measured correlation functions, with three physical parameters: correlation strength parameter λ , Lévy index α and Lévy scale parameter R. The transverse mass dependence of these Lévy parameters is then investigated. Their physical interpretation is also discussed, and the appearance of a new scaling variable is observed.
Vaccination with Combination DNA and Virus-Like Particles Enhances Humoral and Cellular Immune Responses upon Boost with Recombinant Modified Vaccinia Virus Ankara Expressing Human Immunodeficiency Virus Envelope Proteins
Authors: Gangadhara Sailaja , Kwon Young-Man , Jeeva Subbiah , Quan Fu-Shi , Wang Baozhong , Moss Bernard , Compans Richard , Amara Rama , Jabbar M. , Kang Sang-Moo
Published: December 2017

Heterologous prime boost with DNA and recombinant modified vaccinia virus Ankara (rMVA) vaccines is considered as a promising vaccination approach against human immunodeficiency virus (HIV-1). To further enhance the efficacy of DNA-rMVA vaccination, we investigated humoral and cellular immune responses in mice after three sequential immunizations with DNA, a combination of DNA and virus-like particles (VLP), and rMVA expressing HIV-1 89.6 gp120 envelope proteins (Env). DNA prime and boost with a combination of VLP and DNA vaccines followed by an rMVA boost induced over a 100-fold increase in Env-specific IgG antibody titers compared to three sequential immunizations with DNA and rMVA. Cellular immune responses were induced by VLP-DNA and rMVA vaccinations at high levels in CD8 T cells, CD4 T cells, and peripheral blood mononuclear cells secreting interferon (IFN)-γ, and spleen cells producing interleukin (IL)-2, 4, 5 cytokines. This study suggests that a DNA and VLP combination vaccine with MVA is a promising strategy in enhancing the efficacy of DNA-rMVA vaccination against HIV-1.
Interspecific Relationship and Ecological Requirements of Two Potentially Harmful Cyanobacteria in a Deep South-Alpine Lake (L. Iseo, I)
Authors: Nava Veronica , Patelli Martina , Soler Valentina , Leoni Barbara
Published: December 2017

In Lake Iseo (Lombardia, Italy), the predominant species in the cyanobacterial taxa was Planktothrix rubescens. However, since 2014, the presence of an allochthonous Cyanobacteria, Tychonema bourrellyi, able to produce consistent biomasses and harmful toxins, was detected. The causes of this expansion are poorly understood. Many studies have linked the development of allochthonous Cyanobacteria populations with climate change. This study shows the spatio-temporal dynamics, the ecological requirements, and the interspecific relationship of P. rubescens and T. bourrellyi. Samples were collected monthly in 2016 at six different depths in the water column; 20 chemico-physical characteristics were measured; and Cyanobacteria density, morphology, and biovolume were evaluated. The results allowed a comparison of the spatial pattern of the two species, which showed a greater distribution at a depth of 10–20 m, and their seasonal dynamics. Both Cyanobacteria were present throughout the year, with the greatest abundance during the period from March to May. A temporal shift was observed in their development, linked to different capacities for overcoming winter and mixing periods. Principal Component Analysis, performed on 20 observations (4 months × 5 depths), highlighted the important role of the stability of the water column in determining T. bourrellyi settlement in Lake Iseo and the role of solar radiation in spring population development.