bluuebunny/crossref_metadata_2025 huggingface dataset:
Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment
Authors: Torres-Mata Laura B. , García-Pérez Omar , Rodríguez-Esparragón Francisco , Blanco Angeles , Villar Jesús , Ruiz-Apodaca Fernando , Martín-Barrasa José L. , González-Martín Jesús M. , Serrano-Aguilar Pedro , Piñero José E. , Córdoba-Lanús Elizabeth , Lorenzo-Morales Jacob , Clavo Bernardino
Published: July 2022

(1) Background: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) continues to cause profound health, economic, and social problems worldwide. The management and disinfection of materials used daily in health centers and common working environments have prompted concerns about the control of coronavirus disease 2019 (COVID-19) infection risk. Ozone is a powerful oxidizing agent that has been widely used in disinfection processes for decades. The aim of this study was to assess the optimal conditions of ozone treatment for the elimination of heat-inactivated SARS-CoV-2 from office supplies (personal computer monitors, keyboards, and computer mice) and clinical equipment (continuous positive airway pressure tubes and personal protective equipment) that are difficult to clean. (2) Methods: The office supplies and clinical equipment were contaminated in an area of 1 cm2 with 1 × 104 viral units of a heat-inactivated SARS-CoV-2 strain, then treated with ozone using two different ozone devices: a specifically designed ozonation chamber (for low–medium ozone concentrations over large volumes) and a clinical ozone generator (for high ozone concentrations over small volumes). SARS-CoV-2 gene detection was carried out using quantitative real-time polymerase chain reaction (RT-qPCR). (3) Results: At high ozone concentrations over small surfaces, the ozone eliminated SARS-CoV-2 RNA in short time periods—i.e., 10 min (at 4000 ppm) or less. The optimum ozone concentration over large volumes was 90 ppm for 120 min in ambient conditions (24 °C and 60–75% relative humidity). (4) Conclusions: This study showed that the appropriate ozone concentration and exposure time eliminated heat-inactivated SARS-CoV-2 RNA from the surfaces of different widely used clinical and office supplies, decreasing their risk of transmission, and improving their reutilization. Ozone may provide an additional tool to control the spread of the COVID-19 pandemic.
Relationship between Personal Values and Intentions to Purchase Plant-Based Meat Alternatives: Application of the Dual Concern Theory
Authors: Jang Ha-Won , Cho Meehee
Published: July 2022

This study examines consumers’ intentions to purchase plant-based meat alternatives (PBMA), which have been created to protect animal rights, the global environment, and consumers’ health. Data from 319 Korean consumers were analyzed to establish a causal relationship among personal values (egoistic, biospheric, and social-altruistic), the dual concern theory (anticipated positive effect and empathetic concern), and PBMA purchase intentions. Multigroup analysis was performed for all paths according to generation, divided into Generation MZ and the older generation; “MZ” is a compound term referring to millennials and Generation Z, who have grown up in a digital environment; this collective generation comprises individuals born after 1980. Our analysis revealed that, among personal values, biospheric and social-altruistic values had positive effects on both anticipated positive effect and empathetic concern. In turn, these aspects positively influenced PBMA purchase intentions. Particularly, anticipated positive effect had a strong influence. Finally, a moderating effect was confirmed for two paths, and only Generation MZ demonstrated the enhancing influence of biospheric value on both anticipated positive effect and empathetic concern. This study has several implications and contributes to the sustainable growth and development of PBMA and the overall food service industry.
Everyday Discrimination and Depressive Symptoms among Gujarati Adults: Gender Difference in the Role of Social Support
Authors: Yoshihama Mieko , Hong Jun Sung , Yan Yueqi
Published: July 2022

Discrimination against Asians in the USA and its impact on their mental health are urgent public health concerns. Most research on discrimination against Asians has used aggregated Asian group samples. Focusing on Gujaratis, a specific subgroup of Asian Indians, the second-largest Asian group in the USA, this study examined the relationships between everyday discrimination and psychological distress and how they vary by gender. Data were collected via computer-assisted telephone interviews with a representative sample of 553 Gujaratis aged 18 to 65 years residing in a Midwestern state. Negative binomial regression analyses were conducted to examine how exposure to unfair treatment and three types of social support, respectively, was associated with depressive symptoms. For both women and men, unfair treatment was positively associated with depressive symptoms, controlling for sociodemographic characteristics. For women, but not for men, the incidence rate ratio became non-significant when adding social support measures to the model. All three social support measures for women, and only satisfaction with social support for men, were significantly associated with lower depressive symptoms. The findings highlight the need for further research on the role of different types of social support and gender differences, which can inform gender- and socioculturally-relevant intervention efforts.
Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial
Authors: Butera Andrea , Gallo Simone , Pascadopoli Maurizio , Montasser Mona A. , Abd El Latief Mohammad H. , Modica Gioia Giada , Scribante Andrea
Published: July 2022

Introduction: Biomimetic hydroxyapatite-based toothpastes have been investigated in recent years for their remineralizing activity on dental surfaces. The aim of the present study was to evaluate the efficacy of toothpaste containing biomimetic hydroxyapatite versus a 1450 pppm fluoride one in promoting the remineralization and desensitization of white spot lesions. Methods: 40 patients were randomly assigned to two different domiciliary oral hygiene treatments: toothpaste containing 1450 ppm of fluoride (control group) and toothpaste containing biomimetic hydroxyapatite (experimental group). Dental sensitivity/pain and dental erosion were assessed at baseline and after 15, 30, and 90 days using the following indexes: Schiff Air Index (SAI), Visual Analogue Scale (VAS), and Basic Erosive Wear Examination (BEWE). Results: Data were submitted for statistical analysis. SAI significantly decreased after 3 months (T3) of treatment only in the Trial group (p < 0.05). VAS values significantly decreased at T2 in the trial group (p < 0.05) with a further significant reduction at T3 (p < 0.05). BEWE scores did not significantly vary during the follow up neither in the trial nor in the control group. Conclusions: The hydroxyapatite-based toothpaste tested caused a reduction of hypersensitivity/pain values higher than conventional fluoride toothpaste.
Research on Adaptive Management of the Social–Ecological System of a Typical Mine–Agriculture–Urban Compound Area in North Shanxi, China
Authors: Wang Shufei , Li Shengpeng , Yang Kai , Feng Yi , Liu Shihan , Zhang Jianjun , Cao Yingui , Bai Zhongke
Published: July 2022

The mine–agriculture–urban compound area formed under the combined effects of natural conditions, mineral resource endowments, and historical development is affected by severe man-made disturbances, and faces a prominent contradiction between economic development and ecological protection. Guiding the future development is an urgent problem in this region. This research used image data, logical reasoning, and empirical analysis, based on social and economic statistics and land-use data, to analyze the typical characteristics and problems of the social–ecological system in the mine–agriculture–urban compound area. Moreover, we identified future directions for the region guided by policy documents and built a philosophy framework for sustainable development and management of the region based on the concept of adaptability. The results showed the following: (1) At present, the output value of the coal industry accounts for 84.10% of the total regional output value, severely disturbing its social–ecological system, which needs to be protected and restored under human guidance and management. (2) The future development of this region depends on the one hand on green mining, and on the other hand, it is necessary to fully tap the potential of arable land and livestock farms to develop efficient and intensive agriculture. (3) The key contents of the social–ecological system management of the mine–agriculture–urban compound area include resolving the contradiction between development and protection, ensuring development, optimizing industrial structure, and safeguarding public interests. In conclusion, this research can expand the connotation and application scope of adaptive management and provide a reference for such areas facing the prominent contradiction between development and protection.
Changes in the Work Schedule of Nurses Related to the COVID-19 Pandemic and Its Relationship with Sleep and Turnover Intention
Authors: Djupedal Ingebjørg Louise Rockwell , Pallesen Ståle , Harris Anette , Waage Siri , Bjorvatn Bjørn , Vedaa Øystein
Published: July 2022

Background: This study aimed to investigate whether different types of changes in the work schedule of nurses working rotating shifts during the COVID-19 pandemic were associated with sleep duration, sleep quality, and turnover intention. Methods: Cross-sectional questionnaire data from 694 nurses participating in the SUrvey of Shift work, Sleep and Health (SUSSH) were collected between the first and the second wave of the COVID-19 pandemic in Norway. A total of 89.9% were female, and mean age was 44.6 years (SD = 8.6 years). Changes in the shift work schedule related to the pandemic comprised reports of more long workdays (>8 h), less days off between work periods, more night shifts, more quick returns (i.e., 11 h or less between two consecutive shifts), more day shifts, and more evening shifts compared to no change in the respective shift characteristics. Change in sleep duration, sleep quality, and turnover intention as well as demographics were also assessed. Logistic regression analyses were performed to investigate whether changes in the specific work schedules were associated with sleep duration, sleep quality, and turnover intention, controlling for sex, age, cohabitation, children living in household, percentage of full time equivalent and other changes in the work schedule. Results: A total of 17% reported experiencing one or more changes in their work schedule during the pandemic. Experiencing any change in the work schedule predicted worse sleep quality (OR = 2.68, p < 0.001), reduced sleep duration (OR = 4.56, p < 0.001), and higher turnover intention (OR = 1.96, p = 0.006) compared to experiencing no change in work schedule. Among the specific changes in work schedules, experiencing an increase in quick returns had the highest odds ratio for worse sleep quality (OR = 10.34, p = 0.007) and higher turnover intention (OR = 8.49, p = 0.014) compared to those who reported no change in quick returns. Nurses experiencing an increase in long workdays were more likely to report higher turnover intention (OR = 4.37, p = 0.003) compared to those experiencing no change in long workdays. Conclusions: Change in work schedule related to the pandemic was associated with worse sleep quality, reduced sleep duration, and higher turnover intention. Increase in quick returns emerged as especially problematic in terms of sleep quality and turnover intention, along with long workdays, which were associated with higher turnover intention.
Nutritional Education and the State of Oral Health in Adolescents
Authors: Jaraszek Małgorzata , Hanke Wojciech , Marcinkiewicz Andrzej
Published: July 2022

Background. Health promotion of adolescents is a high priority in Poland. Epidemiological data still indicates the low effectiveness of the health care system in this area. The relationship between the state of oral health and the vocational education of adolescents seems to be justified. The objective is to evaluate changes in the oral health status, eating habits, and the relationship between oral health and lifestyle related to vocational education among students from a secondary technical school of gastronomy and electro-engineering and information technology. Methods. The study consisted of two stages (at the beginning and end of education) and two parts: a questionnaire and a dental examination. The study group initially included 55 male students from the secondary technical school of gastronomy and 54 in electro-engineering and information technology school. In the second stage of the study, it was 42 and 51, respectively. Results. After three years, in the engineering and information technology group, compared to gastronomy one, a statistically significant increase in caries prevalence and the number of students eating between meals was observed. Conclusions. Professional education on proper nutrition conducted in the gastronomic school could have a decisive impact on the better oral health status of students.
Two Semiconductor Companies’ Financial Support Compensation (FSC) Programs for Semiconductor Workers with Suspected Work-Related Diseases (WRDs)
Authors: Kim Hyoung-Ryoul , Park Dong-Uk
Published: July 2022

This study described two companies’ financial compensation programs for semiconductor workers with suspected work-related diseases (WRDs) and discussed the major related issues. The key contents of the programs found on the websites opened by two semiconductor companies (Samsung and SK Hynix) were cited. In order to select the suspected WRDs for the FSC, all available epidemiologic studies related to health problems conducted in the semiconductor industry were reviewed. Most program contents are similar, although the amount of financial compensation and a few types of disease available for compensation differ between the companies. The group of cancer, rare disease, childhood rare disease among children born to semiconductor workers (hereafter selected diseases among offspring), and fetal loss, including spontaneous abortion (SAB) and stillbirth, were considered for compensation. An employment duration of longer than one year on a semiconductor production line is required for FSC for cancer or rare disease. The FSC for SAB and offspring disease require a period of employment longer than one month, either before three months prior to conception or between conception and childbirth. The maximum amount of compensation per type of cancer and rare disease was fixed based on the medical treatment fee. The FSC programs of the two companies have been operated successfully to date. These programs are arguably considered to contribute to resolving the conflict between companies and workers with WRDs.
Effects of the Task Complexity on the Single Movement Response Time of Upper and Lower Limbs in Police Officers
Authors: Janković Dunja , Čvorović Aleksandar , Dopsaj Milivoj , Prćić Iva , Kukić Filip
Published: July 2022

Police officers occasionally encounter belligerents resisting or even physically assaulting them without or with objects. The self-defense or legal utilization of use of force to disable the offender from harming an officer or others may depend on a single movement speed of hands and legs. This study investigated the effects of task complexity on a single movement response time of the upper and lower limbs in police officers. The sample consisted of 32 male police officers aged between 23 and 50 years. They performed a single movement as fast as possible with their upper and lower limb in three incrementally more complex tasks. In the first task, participants acted on a light signal and with their dominant limb they had to turn off the signal as fast as possible. In the second task, on the light signal, participants could turn off the light with free choice of the upper limb in a hand task or lower limb in a leg task. In the third task, participants had to turn the light off with the right limb if the light turned red and with the left limb if the light turned blue. The BlazePod device was used to assess the movement response time. The results show that there was a significant effect of task complexity on the single movement response time of the hand (F = 24.5, p < 0.001) and leg (F = 46.2, p < 0.001). The training of police officers should utilize specific and situational tasks to improve movement response time by improving the redundancy in decision-making processes during work-specific tasks of different complexity.
Multi-Scenario Simulation of Land Use and Habitat Quality in the Guanzhong Plain Urban Agglomeration, China
Authors: Ye Hao , Song Yongyong , Xue Dongqian
Published: July 2022

Regional habitat quality is a proxy of biodiversity. Simulating changes in land use and habitat quality in urban agglomerations is the scientific basis for promoting the optimal allocation of land resources and building ecological civilizations in urban agglomerations. Therefore, we established a research framework mainly consisting of the Future Land Use Simulation (FLUS) model with the Integrated Valuation of Environmental Services and Tradeoffs (InVEST) model to predict the spatial and temporal distribution of habitat quality. In addition, we set three scenarios which were a natural development scenario, a cultivated land protection scenario, and an ecological protection scenario to analyze the changes of habitat quality in the Guanzhong Plain urban agglomeration in 2035. The results showed that: (1) the FLUS model had an excellent effect on the simulation of land-use change in the Guanzhong Plain urban agglomeration, with an overall accuracy of 0.952 and a kappa coefficient of 0.924. (2) From 2000 to 2035, the cultivated land area of the study area, which was mainly transferred into construction land and grassland, shrank due to the process of urbanization. (3) The habitat quality score of this region gradually decreased from 2000 to 2020, and it continued to decrease to 0.6921 in 2035 under the natural development scenario, while it increased under the other two scenarios. The low-value areas of habitat quality were mainly located in the middle of this region with Xi’an as the core, whereas the high-value areas were mainly distributed in the southern Qinling Mountains and the northern Loess Plateau. (4) Of the different scenarios, the ecological protection scenario had the highest habitat quality, while the natural development scenario had the lowest. Besides this, we also found that the cultivated protection scenario had high habitat quality, which was mainly because the rate of occupation of ecological land was controlled. The results are expected to provide a scientific basis for optimizing the spatial allocation of land resources and promoting the sustainable use of land space in other ecologically fragile urban agglomerations.
Knowledge, Practices and Attitudes towards Silver Diamine Fluoride Therapy among Dentists in Japan: A Mixed Methods Study
Authors: Chai Hollis Haotian , Kiuchi Sakura , Osaka Ken , Aida Jun , Chu Chun-Hung , Gao Shiqian (Sherry)
Published: July 2022

In 2021, the World Health Organization included silver diamine fluoride (SDF) as an essential medicine to manage caries in adults and children. SDF was developed in the 1960s, but its use for children became unpopular in Japan because of the decline and low prevalence of early childhood caries. This mixed methods study explored the knowledge, practices and attitudes towards SDF therapy among dentists promoting fluoride use in Japan. It also investigated senior dentists’ perceptions of SDF therapy in Japan. The quantitative study invited all 173 members of the largest organisation promoting fluoride use in Japan to complete a web-based questionnaire survey. Sixty (60/173; 35%) dentists promoting fluoride use in Japan completed the questionnaire survey. All dentists knew of SDF treatment, and 50 (50/60; 83%) used SDF for dental care. Fifty-nine dentists (59/60; 98%) agreed that SDF therapy was simple and quick. All 60 dentists agreed that SDF was effective to arrest caries; 51 dentists (51/60; 85%) agreed that SDF was effective to prevent caries. Most dentists (51/60; 85%) were concerned about SDF’s unaesthetic staining. Fifty-seven dentists (57/60; 95%) used SDF to arrest primary posterior teeth, and 52 dentists (52/60; 87%) used SDF to arrest root caries. However, 25 dentists (25/60; 42%) did not use SDF to prevent caries in permanent teeth. The qualitative study interviewed 12 senior dentists using snowball sampling and achieved data saturation. The dentists opined that SDF therapy was effective, simple, painless, non-invasive and inexpensive. SDF is seldom used in Japan at present because of the unaesthetic black staining and the low prevalence of early childhood caries; however, it can regain popularity by arresting root caries in the aging population.
Rationale and Purpose: The FLUTE Study to Evaluate Fluorography Mass Screening for Tuberculosis and Other Diseases, as Conducted in Eastern Europe and Central Asia Countries
Authors: Smelov Vitaly , Trusova Olga , Barbier Sylvaine , Muwonge Richard , Grankov Viatcheslav , Rusovich Valiantsin , Baena Armando , Gaffield Mary Lyn , Corbex Marilys Anne , Dara Masoud
Published: July 2022

In Belarus and several EECA countries, periodic population-based chest X-ray “fluorography programme” use as a mass screening tool for the diagnosis of tuberculosis (TB) has been used for decades. This mass screening has also often been justified for the early detection of lung cancer (LC), although no mortality benefits were demonstrated by screening with chest X-ray in international randomized trials. In Belarus, fluorography testing is mandatory every one to three years for all adults depending on age and the so-called “risk groups”. The World Bank and WHO estimate that Belarus spends USD11 million annually on mass fluorography screening and advocate for more targeted screening approaches to increase diagnostic yield for TB and not to use it for screening for LC. The study is a retrospective review of medical records to assess the yield of fluorography to detect true cases of LC and/or TB in asymptomatic patients in two rural and two urban districts in Belarus for 2015–2017 with positive screening results for presumed of TB or LC. The study provided the rationale to implement the improved policy and practices regarding the role of fluorography in the early detection of LC and TB in Belarus and elsewhere.
Analysis of Survival of Patients Hospitalized with COVID-19 in Espírito Santo, Brazil
Authors: Garbin Juliana Rodrigues Tovar , Leite Franciéle Marabotti Costa , Lopes-Júnior Luís Carlos , Dell’Antonio Cristiano Soares da Silva , Dell’Antonio Larissa Soares , Santos Ana Paula Brioschi dos
Published: July 2022

Objective: To analyze the survival of patients hospitalized with COVID-19 and its associated factors. Methods: Retrospective study of survival analysis in individuals notified and hospitalized with COVID-19 in the state of Espírito Santo, Brazil. As data source, the reports of hospitalized patients in the period from 1 March 2020, to 31 July 2021 were used. The Cox regression analysis plus the proportional risk assessment (assumption) were used to compare hospitalization time until the occurrence of the event (death from COVID-19) associated with possible risk factors. Results: The sample comprised 9806 notifications of cases, with the occurrence of 1885 deaths from the disease (19.22%). The mean age of the group was 58 years (SD ± 18.3) and the mean hospital length of stay was 10.5 days (SD ± 11.8). The factors that presented a higher risk of death from COVID-19, associated with a lower survival rate, were non-work-related infection (HR = 4.33; p < 0.001), age group 60–79 years (HR: 1.62; p < 0.001) and 80 years or older (HR = 2.56; p < 0.001), presence of chronic cardiovascular disease (HR = 1.18; p = 0.028), chronic kidney disease (HR = 1.5; p = 0.004), smoking (HR = 1.41; p < 0.001), obesity (HR = 2.28; p < 0.001), neoplasms (HR = 1.81; p < 0.001) and chronic neurological disease (HR = 1.68; p < 0.001). Conclusion: It was concluded that non-work-related infection, age group above or equal to 60 years, presence of chronic cardiovascular disease, chronic kidney disease, chronic neurological disease, smoking, obesity and neoplasms were associated with a higher risk of death, and, therefore, a lower survival in Brazilian patients hospitalized with COVID-19. The identification of priority groups is crucial for Health Surveillance and can guide prevention, control, monitoring, and intervention strategies against the new coronavirus.
NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review
Authors: Saraniti Carmelo , Gallina Salvatore , Verro Barbara
Published: July 2022

Narrow-band imaging (NBI) represents a valid aid in laryngeal squamous cell carcinoma (LSCC) diagnosis for detecting vascular changes. However, LSCC and laryngeal papillomatosis (LP) show similar vascular patterns that may lead to misdiagnosis and improper treatment. This review aims to deepen this NBI limit in order to stress a careful preoperative evaluation of laryngeal lesions. The research was carried out on PubMed, Web of Science and Scopus databases using specific keywords. The topic of research was assessed by these parameters: accuracy, sensitivity, specificity, and positive and negative predictive values. This review included only five articles: they demonstrated that NBI is better than white-light endoscopy in detecting LSCC and LP. They also reported that LP is frequently mistaken for LSCC, resulting in high rates of false positives using NBI. This is the first review that emphasized this NBI limitation in distinguishing between LP and LSCC in cases of a type V pattern of intraepithelial papillary capillary loop. Although NBI application increased the rate of early cancer detection, LP reduces NBI accuracy. This drawback may lead to misdiagnosis and improper treatment. Our advice is to be careful in cases of type V pattern on NBI and to research LP epithelial and clinical features because it could be a pitfall.
The Impact of Social Pension Schemes on the Mental Health of the Chinese Elderly: A Mediating Effect Perspective of Two-Way Intergenerational Support
Authors: Zhang Dongling , Wang Yanyan , Jiao Yuxin
Published: July 2022

With the rapid decline in China’s fertility rate, the acceleration of aging, the continuous miniaturization and nucleation of China’s family structure, and the deterioration of the elderly’s living conditions and mental states, the elderly’s mental health has emerged as a major public health issue and a major social problem. Pensions are the elderly’s primary source of income, and they can help them meet their basic needs while also promoting family harmony and improving their mental health. Based on the data of the 2012, 2016, and 2018 Chinese Family Panel Studies (CFPS), we empirically examined the impact of pensions on the elderly’s mental health by using the fixed effects model, mediating effect model, and so on. The results show that receiving pension benefits can significantly reduce the level of depression and improve the mental health of the elderly. Receiving pension benefits causes reverse intergenerational economic transfer, which reduces the effect of pensions on the elderly’s mental health to some extent, but the life care and mental comfort provided by children increases when the elderly share pensions with their children. Overall, receiving pension benefits improves the mental health of the elderly. In addition, the effect of pensions on the elderly with different characteristics is heterogeneous. The older elderly, women, the elderly living with their children, and the elderly in rural areas all benefit more from receiving pension benefits. Moreover, the worse the mental health of the elderly is, the stronger the influence of pensions on their mental health is. Our discussion has important policy implications.
Changes in Tumor Necrosis Factor α (TNFα) and Peptidyl Arginine Deiminase 4 (PAD-4) Levels in Serum of General Treated Psoriatic Patients
Authors: Czerwińska Joanna , Kasprowicz-Furmańczyk Marta , Placek Waldemar , Owczarczyk-Saczonek Agnieszka
Published: July 2022

Psoriasis is an autoimmune disease in which the disturbed dependencies between lymphocytes, dendritic cells, keratinocytes and neutrophils play the most important role. One of them is the overproduction of neutrophil extracellular traps (NETs). The release of NETs can be induced by pathogens, as well as antibodies and immune complexes, cytokines and chemokines, including TNFα. The first step of the NET creation is the activation of peptidyl arginine deiminase 4 (PAD-4). PAD-4 seems to be responsible for citrullination of histones and chromatin decondensation, but the data on PAD-4 in NETs is inconclusive. Thus, the current study aimed to determine PAD-4 and TNFα levels in the serum of psoriatic patients by ELISA and observe the response of these factors to systemic (anti-17a, anti-TNFα and methotrexate) therapies. Increased levels of both PAD-4 and its main stimulus factor TNFα in pre-treatment patients have been reported along with the concentrations of proteins correlated with disease severity (PASI, BSA). Before treatment, the irregularities in the case of anti-nuclear antibodies level (ANA) were also observed. All of the applied therapies led to a decrease in PAD-4 and TNFα levels after 12 weeks. The most significant changes, both in protein concentrations as well as in scale scores, were noted with anti-TNFα therapy (adalimumab and infliximab). This phenomenon may be associated with the inhibition of TNFα production at different stages of psoriasis development, including NET creation. The obtained data suggest the participation of PAD-4 in the activation of neutrophils to produce NETs in psoriasis, which may create opportunities for modern therapies with PAD inhibitors. However, further exploration of gene and protein expression in psoriatic skin is needed.
Air Pollution and Workplace Choice: Evidence from China
Authors: Lin Tao , Qian Wenhao , Wang Hongwei , Feng Yu
Published: July 2022

Understanding the impacts of air pollution on public health and individual behavior is crucial for optimal environmental policy design. Using 2015 census microdata in China, this paper examined the causal effect of air pollution on working place choice. The research design relies on a regression discontinuity design based on China’s Huai River Policy. The discontinuity in air pollution caused by the Huai River Policy provides a natural experiment to estimate the impact of air pollution. The results show that air pollution significantly increases the possibility of individuals working near home. The positive effect of air pollution on working near home is more significant for women, the elderly, urban individuals and those individuals working in secondary and tertiary industries. This study improves our understanding of the health effects and avoidance behavior associated with environmental hazards, discusses the negative impact of air pollution on labor mobility and mismatch by making individuals work nearby, and emphasizes that strengthening air pollution control should be a long-term policy.
Understanding Medical Students’ Perceptions of and Behavioral Intentions toward Learning Artificial Intelligence: A Survey Study
Authors: Li Xin , Jiang Michael Yi-chao , Jong Morris Siu-yung , Zhang Xinping , Chai Ching-sing
Published: July 2022

Medical students learning to use artificial intelligence for medical practices is likely to enhance medical services. However, studies in this area have been lacking. The present study investigated medical students’ perceptions of and behavioral intentions toward learning artificial intelligence (AI) in clinical practice based on the theory of planned behavior (TPB). A sum of 274 Year-5 undergraduates and master’s and doctoral postgraduates participated in the online survey. Six constructs were measured, including (1) personal relevance (PR) of medical AI, (2) subjective norm (SN) related to learning medical AI, (3) perceived self-efficacy (PSE) of learning medical AI, (4) basic knowledge (BKn) of medical AI, (5) behavioral intention (BI) toward learning medical AI and (6) actual learning (AL) of medical AI. Confirmatory factor analysis and structural equation modelling were employed to analyze the data. The results showed that the proposed model had a good model fit and the theoretical hypotheses in relation to the TPB were mostly confirmed. Specifically, (a) BI had a significantly strong and positive impact on AL; (b) BI was significantly predicted by PR, SN and PSE, whilst BKn did not have a direct effect on BI; (c) PR was significantly and positively predicted by SN and PSE, but BKn failed to predict PR; (d) both SN and BKn had significant and positive impact on PSE, and BKn had a significantly positive effect on SN. Discussion was conducted regarding the proposed model, and new insights were provided for researchers and practitioners in medical education.
Coping Strategies to Enhance the Mental Wellbeing of Sexual and Gender Minority Youths: A Scoping Review
Authors: Lucassen Mathijs F. G. , Núñez-García Alicia , Rimes Katharine A. , Wallace Louise M. , Brown Katherine E. , Samra Rajvinder
Published: July 2022

Robust population-based research has established that sexual and gender minority youths (SGMYs) are at an increased risk of mental ill-health, but there is a dearth of literature that seeks to explore how to best support SGMY mental wellbeing. This scoping review aims to identify findings related to coping strategies and/or interventions for building resilience and/or enhancing the mental wellbeing of SGMYs. PRISMA extension for scoping review (PRISMA-ScR) guidelines was utilized for this review. Studies were included if they were peer-reviewed papers containing primary data; reported psycho-social coping strategies for SGMY; were conducted with SGMYs in the adolescent age range; and were published in English. MEDLINE, Embase, and PsycINFO databases were searched. Of the 3692 papers initially identified, 68 papers were included with 24 intervention-focused studies of 17 unique interventions found. The most commonly cited therapeutic modality was cognitive behavioral therapy (CBT) (n = 11 studies). Despite the need to support the mental wellbeing of SGMYs, few interventions focused on this area and unique populations have been reported upon in the peer-reviewed literature. As a result, there is considerable potential to develop supports for SGMYs.
Adolescents, Young Adults, and Adults Continue to Use E-Cigarette Devices and Flavors Two Years after FDA Discretionary Enforcement
Authors: McCauley Devin M. , Gaiha Shivani Mathur , Lempert Lauren Kass , Halpern-Felsher Bonnie
Published: July 2022

This study assesses the use of e-cigarette devices and flavors using a large, cross-sectional survey of adolescents, young adults, and adults (N = 6131; ages 13–40 years old; Mage = 21.9) conducted from November to December 2021, 22 months after the FDA announced its prioritized enforcement policy against some flavored pod/cartridge-based e-cigarettes. We analyzed the patterns of use by age group: adolescents and young adults (AYAs) under 21 (minimum age of e-cigarette sales), young adults (21–24 years old), and adults (25–40 years old). The participants reported using e-cigarettes ever (44.2% < 21; 67.1% 21–24; 58.0% > 24), in the past 30 days (29.8% < 21; 52.6% 21–24; 43.3% > 24), and in the past 7 days (24.5% < 21; 43.9% 21–24; 36.5% > 24). Disposables were the most used e-cigarette device type across age groups (39.1% < 21; 36.9% 21–24; 34.5% > 24). Fruit, sweet, mint, and menthol flavors were popular across age groups; however, chi-squared tests for trends in proportions revealed age-related trends in past 30-day flavor use by device type. Findings suggest current AYA e-cigarette use may be higher than recorded by the NYTS 2021. The FDA, states, and localities should adopt more comprehensive restrictions on flavored e-cigarette products in order to reduce adolescent and young adult e-cigarette use.
How Daily Obstacles Affect Frontline Healthcare Professionals’ Mental Health during Omicron: A Daily Diary Study of Handwashing Behavior
Authors: Khan Nazeer Hussain , Hassan Sajid , Bahader Sher , Fatima Sidra , Zaidi Syed Muhammad Imran Haider , Virk Razia , Jiang Kexin , Jiang Enshe
Published: July 2022

Based on coping theory, the current research examines how and why COVID-19 phobia affects frontline healthcare professionals’ mental health, as well as their burnout and work-related stress. We focused on the mediating role of burnout and work-related stress in this study. In the current study, we also examined the moderating influence of healthcare professionals’ handwashing behavior using the Hayes Process model. We employed a daily diary approach to collect data from respondents in Pakistan’s frontline healthcare professionals (n = 79, 79 × 10 = 790) who were directly treating COVID-19 patients during the omicron wave. According to the findings of the study, COVID-19 phobia significantly disturbs healthcare professionals’ mental health, as well as significantly strengthens burnout and work-related stress. The findings also demonstrated that burnout significantly negatively influences mental health. The mediation influence of burnout and work-related stress in the association between COVID-19 phobia and mental health has shown to be significant. The moderation analysis revealed that high handwashing behavior significantly buffers the negative impact of COVID-19 phobia, as well as the adverse effect of burnout on healthcare professionals’ mental health. Moreover, our findings have theoretical and managerial implications, as well as new research directions for scholars to understand the adverse impact of daily obstacles on professionals’ (nurses and doctors, etc.) mental health and work performance, as well as issues based on resource conversation philosophy.
Multipurpose GIS Portal for Forest Management, Research, and Education
Authors: Zápotocký Martin , Koreň Milan
Published: July 2022

The main objective of this research was to develop a web-based geographic information system (GIS) based on a detailed analysis of user preferences from the perspective of forest research, management and education. An anonymous questionnaire was used to elicit user preferences for a hardware platform and evaluations of web-mapping applications, geographic data, and GIS tools. Mobile GIS was used slightly more often than desktop GIS. Web-mapping applications that provide information to the public and the present research results were rated higher than the forest management application. Orthophotos for general purposes and thematic layers such as forest stand maps, soils, protected areas, cadastre, and forest roads were preferred over highly specialized layers. Tools for data searching, map printing, measuring, and drawing on digital maps were rated higher than tools for online map editing and geographic analysis. The analysis of user preferences was used to design a new multipurpose GIS portal for the University Forest Enterprise. The GIS portal was designed with a three-tier architecture on top of the software library for managing user access, working interactively with digital maps, and managing web map applications. The web map applications focus on tools and geographic information not available elsewhere, specifically timber harvest and logistics, research plots, and hunting game management.
Analysis of the Spatio-Temporal Characteristics of Nanjing’s Urban Expansion and Its Driving Mechanisms
Authors: Tao Yiming , Ye Ruhai
Published: July 2022

The expansion and evolution of urban areas are the most perceptible manifestations of the transformation of the urban spatial form. This study uses remote sensing images of Nanjing from 2001, 2006, 2011, 2016, and 2021, along with socio-economic data to analyse the spatio-temporal characteristics of the city’s urban expansion. Furthermore, we utilize a binary logistic regression to quantitatively analyse the driving forces in each stage. We find that from 2001 to 2021, Nanjing’s urban area expanded approximately 3.97 times. Notably, the city started moving from a stage of medium-speed development to rapid development in 2006, and then slowed down and returned to medium-speed development in 2011. The urban land mainly expanded in the north, northeast, southeast, and southwest directions in a lopsided cross-shape roughly along the northwest-southeast direction; meanwhile, the city’s centre of gravity continuously moved towards the southeast. Among the driving factors, neighbourhood (distance from planned commercial centres, railways, and highways), topography, and geolocation (distance from the Yangtze River, and elevation) had a greater, albeit inhibitory effect on urban expansion. However, the effects of different socio-economic factors (GDP per capita, resident population, secondary and tertiary industry, etc.) varied across different time periods.
The Role and Therapeutic Potential of the Integrated Stress Response in Amyotrophic Lateral Sclerosis
Authors: Marlin Elías , Viu-Idocin Cristina , Arrasate Montserrat , Aragón Tomás
Published: July 2022

In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical and spinal cord motor neurons triggers the activation of the integrated stress response (ISR), an intracellular signaling pathway that remodels translation and promotes a gene expression program aimed at coping with stress. Beyond its neuroprotective role, under regimes of chronic or excessive stress, ISR can also promote cell/neuronal death. Given the two-edged sword nature of ISR, many experimental attempts have tried to establish the therapeutic potential of ISR enhancement or inhibition in ALS. This review discusses the complex interplay between ISR and disease progression in different models of ALS, as well as the opportunities and limitations of ISR modulation in the hard quest to find an effective therapy for ALS.
Genetically Encoded Fluorescent Sensors for SARS-CoV-2 Papain-like Protease PLpro
Authors: Sokolinskaya Elena L. , Putlyaeva Lidia V. , Polinovskaya Vasilisa S. , Lukyanov Konstantin A.
Published: July 2022

In the SARS-CoV-2 lifecycle, papain-like protease PLpro cuts off the non-structural proteins nsp1, nsp2, and nsp3 from a large polyprotein. This is the earliest viral enzymatic activity, which is crucial for all downstream steps. Here, we designed two genetically encoded fluorescent sensors for the real-time detection of PLpro activity in live cells. The first sensor was based on the Förster resonance energy transfer (FRET) between the red fluorescent protein mScarlet as a donor and the biliverdin-binding near-infrared fluorescent protein miRFP670 as an acceptor. A linker with the PLpro recognition site LKGG in between made this FRET pair sensitive to PLpro cleavage. Upon the co-expression of mScarlet-LKGG-miRFP670 and PLpro in HeLa cells, we observed a gradual increase in the donor fluorescence intensity of about 1.5-fold. In the second sensor, both PLpro and its target—green mNeonGreen and red mScarletI fluorescent proteins separated by an LKGG-containing linker—were attached to the endoplasmic reticulum (ER) membrane. Upon cleavage by PLpro, mScarletI diffused from the ER throughout the cell. About a two-fold increase in the nucleus/cytoplasm ratio was observed as a result of the PLpro action. We believe that the new PLpro sensors can potentially be used to detect the earliest stages of SARS-CoV-2 propagation in live cells as well as for the screening of PLpro inhibitors.
Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
Authors: Kang Sunghyun , Park Hwan-Woo , Han Kyung Ho
Published: July 2022

Iodotyrosine deiodinase (IYD) is a type of deiodinase enzyme that scavenges iodide from the thyroid gland. Previously, we showed that H3 Ab acts as an agonist on IYD to induce migration of cells to the heart and differentiate human stem cells into brown adipocyte-like cells. To continue this study, we investigated the dual function of IYD in hypothyroidism by blocking IYD and in thermogenesis by looking at the induction of brown adipocyte-like cells by treatment with H3 Ab in a mouse model. Surprisingly, our results suggest H3 Ab acts on IYD as both an antagonist and agonist to reduce T4 and increase core body temperature in the mouse model. Taken together, the data suggest IYD has a dual function that can regulate physiological metabolism and enhance thermogenesis.
Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 2: Subtypes and Divergent Differentiation
Authors: Sanguedolce Francesca , Zanelli Magda , Palicelli Andrea , Ascani Stefano , Zizzo Maurizio , Cocco Giorgia , Björnebo Lars , Lantz Anna , Landriscina Matteo , Conteduca Vincenza , Falagario Ugo Giovanni , Cormio Luigi , Carrieri Giuseppe
Published: July 2022

Following several attempts to achieve a molecular stratification of bladder cancer (BC) over the last decade, a “consensus” classification has been recently developed to provide a common base for the molecular classification of bladder cancer (BC), encompassing a six-cluster scheme with distinct prognostic and predictive characteristics. In order to implement molecular subtyping (MS) as a risk stratification tool in routine practice, immunohistochemistry (IHC) has been explored as a readily accessible, relatively inexpensive, standardized surrogate method, achieving promising results in different clinical settings. The second part of this review deals with the pathological and clinical features of the molecular clusters, both in conventional and divergent urothelial carcinoma, with a focus on the role of IHC-based subtyping.
The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy
Authors: Dabravolski Siarhei A. , Sadykhov Nikolay K. , Kartuesov Andrey G. , Borisov Evgeny E. , Sukhorukov Vasily N. , Orekhov Alexander N.
Published: July 2022

Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and arrhythmia) in the absence of other cardiac risk factors (such as hypertension or coronary artery disease). Although the pathogenesis of DCM remains unclear currently, mitochondrial structural and functional dysfunctions are recognised as a central player in the DCM development. In this review, we focus on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression. Based on the crucial role of mitochondria in DCM, application of mitochondria-targeting therapies could be effective strategies to slow down the progression of the disease.