bluuebunny/crossref_metadata_2025 huggingface dataset:
Acknowledgement to Reviewers of Economies in 2017
Authors:   Economies Editorial Office
Published: January 2018

Peer review is an essential part in the publication process, ensuring that Economies maintains high quality standards for its published papers.[...]
Location Planning for Dynamic Wireless Charging Systems for Electric Airport Passenger Buses
Authors: Helber Stefan , Broihan Justine , Jang Young , Hecker Peter , Feuerle Thomas
Published: January 2018

The majority of the ground vehicles operating on the airside parts of commercial airports are currently powered by diesel engines. These include vehicles such as apron buses, fuel trucks, and aircraft tractors. Hence, these vehicles contribute to the overall CO 2 emissions of the aviation transport system and thus negatively influence its environmental footprint. To reduce this damaging environmental impact, these vehicles could potentially be electrified with on-board batteries as their energy sources. However, the conductive charging of such vehicles via stationary cable connections is rather time-consuming. A dynamic wireless charging system to supply public transportation passenger buses with electric energy while in motion has recently been installed on the Korea Advanced Institute of Science and Technology (KAIST) campus and in the Korean city of Gumi. In this paper, we study configuration problems related to the use of this technology to make airport operations more environmentally sustainable. We concentrate on the power supply for apron buses and analyze the location planning problems related to the distribution of the required power supply and the wireless charging units in the apron road system. To this end, we develop a formal optimization model and discuss the first numerical results.
Numerical Assessment of the Influences of Gas Pressure on Coal Burst Liability
Authors: Zhao Haochen , Kaunda Rennie
Published: January 2018

When coal mines exploit deep seams with high-gas content, risks are encountered due to the additional high likelihood of rock bursting potential problems. The bursts of coal pillars usually lead to severe fatalities, injuries, and destruction of property, including impeding access to active mine workings underground. The danger exists given that conditions in the already highly brittle coal material can be exacerbated by high stress and high gas pressure conditions. It is thus critical to develop methods that improve current understanding about bursting liability, and techniques to forecast or prevent coal bursting in underground coal mines. This study uses field data from a deep coal mine, and numerical modeling to investigate the effects of gas pressure and mechanical compressive stresses on coal bursting liability in high gas content coal seams. The bursting energy index is adopted to determine the coal bursting liability under high gas pressure conditions. The adopted methodology uses a two-staged approach comprising investigating the influence of gas pressure on the bursting liability of coal pillar, and the influence of the gas pressure on the resulting pillar failure mode. Based on numerical simulations of coal pillars, correlations are observed between the magnitudes of gas pressures and the bursting energy index. Irrespective of pillar size, failure time is shortest when the gas pressure achieves a threshold value between 50 kPa to 70 kPa. At 50 kPa, the value of the BEI increases by 50% going from the 4 m pillar to the 6 m pillar. The value of the BEI increases by 43% going from the 6 m high pillar to the 8 m high pillar at 50 kPa. When pillars fail there is a degree of stress relief leading to a reduction in bursting liability. The results suggest that before 50 kPa, pillar failure is largely due to mechanical loading. After 50 kPa, pillar failure is largely due to excessive gas pressures.
Comparative Study of Electric Energy Storages and Thermal Energy Auxiliaries for Improving Wind Power Integration in the Cogeneration System
Authors: Yu Yanjuan , Chen Hongkun , Chen Lei
Published: January 2018

In regards to the cogeneration system in Northern China, mainly supported by combined heat and power (CHP) plants, it usually offers limited operation flexibility due to the joint production of electric and thermal power. For that large-scale wind farms included in the cogeneration system, a large amount of wind energy may have to be wasted. To solve this issue, the utilization of the electric energy storages and the thermal energy auxiliaries are recommended, including pumped hydro storage (PHS), compressed air energy storage (CAES), hydrogen-based energy storage (HES), heat storage (HS), electric boilers (EB), and heat pumps (HP). This paper proposes a general evaluation method to compare the performance of these six different approaches for promoting wind power integration. In consideration of saving coal consumption, reducing CO2 emissions, and increasing investment cost, the comprehensive benefit is defined as the evaluation index. Specifically, a wind-thermal conflicting expression (WTCE) is put forward to simplify the formulation of the comprehensive benefit. Further, according to the cogeneration system of the West Inner Mongolia (WIM) power grid, a test system is modelled to perform the comparison of the six different approaches. The results show that introducing the electric energy storages and the thermal energy auxiliaries can both contribute to facilitating wind power integration, and the HP can provide the best comprehensive benefit.
Series-Connected High Frequency Converters in a DC Microgrid System for DC Light Rail Transit
Authors: Lin Bor-Ren
Published: January 2018

This paper studies and presents a series-connected high frequency DC/DC converter connected to a DC microgrid system to provide auxiliary power for lighting, control and communication in a DC light rail vehicle. Three converters with low voltage and current stresses of power devices are series-connected with single transformers to convert a high voltage input to a low voltage output for a DC light rail vehicle. Thus, Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) with a low voltage rating and a turn-on resistance are adopted in the proposed circuit topology in order to decrease power losses on power switches and copper losses on transformer windings. A duty cycle control with an asymmetric pulse-width modulation is adopted to control the output voltage at the desired voltage level. It is also adopted to reduce switching losses on MOSFETs due to the resonant behavior from a leakage inductor of an isolated transformer and output capacitor of MOSFETs at the turn-on instant. The feasibility and effectiveness of the proposed circuit have been verified by a laboratory prototype with a 760 V input and a 24 V/60 A output.
A Novel Concept for Three-Phase Cascaded Multilevel Inverter Topologies
Authors: Hasan Md , Abu-Siada A. , Islam Syed , Muyeen S.
Published: January 2018

One of the key challenges in multilevel inverters (MLIs) design is to reduce the number of components used in the implementation while maximising the number of output voltage levels. This paper proposes a new concept that facilitates a device count reduction technique of existing cascaded MLIs. Moreover, the proposed concept can be utilised to extend existing single phase cascaded MLI topologies to three-phase structure without tripling the number of semiconductor components and input dc-supplies as per the current practice. The new generalized concept involves two stages; namely, cascaded stage and phase generator stage. The phase generator stage is a combination of a conventional three-phase two level inverter and three bi-directional switches while the cascaded stage can employ any existing cascaded topology. A laboratory prototype model is built and extensive experimental analyses are conducted to validate the feasibility of the proposed cascaded MLI concept.
Study on the Potential of Rice Straws as a Supplementary Fuel in Very Small Power Plants in Thailand
Authors: Cheewaphongphan Penwadee , Junpen Agapol , Kamnoet Orachorn , Garivait Savitri
Published: January 2018

Agricultural residue is a major raw material for renewable energy production, particularly heat production, in Thailand. Meanwhile, the process-based residue, such as bagasse, rice husk, wood residue, palm fiber, palm shell, and saw dust, is used as a fuel for energy production in the agro-industry. Hence, this study is intended to assess the net potential and capacity of alternative agricultural residues, specifically rice straws, to serve as the supplementary fuel for very small power plants (VSPPs) in Thailand. According to the results obtained during the crop season of 2015/2016, approximately 26 Mt of rice straws were generated upon the harvesting process. The net potential of rice straws, including those that were burned and those that were left in the fields, was only about 15% or 3.85 Mt, which could be used for heat and electricity production at 1331 kilotons of oil equivalent (ktoe) or 457 MWe. As agro-residues vary by seasonality, the peak season of rice straws was in November, where approximately 1.64 Mt (43%) were generated, followed by December, at 1.32 Mt (34%). On the basis of the results, rice straw has the potential to serve as a fuel supply for VSPPs at 14.2%, 21.6%, 26.3%, and 29.0% for the radii of compilation at 24, 36, 48 km and 60 km, respectively.
Mapping of Cold-Water Coral Carbonate Mounds Based on Geomorphometric Features: An Object-Based Approach
Authors: Diesing Markus , Thorsnes Terje
Published: January 2018

Cold-water coral reefs are rich, yet fragile ecosystems found in colder oceanic waters. Knowledge of their spatial distribution on continental shelves, slopes, seamounts and ridge systems is vital for marine spatial planning and conservation. Cold-water corals frequently form conspicuous carbonate mounds of varying sizes, which are identifiable from multibeam echosounder bathymetry and derived geomorphometric attributes. However, the often-large number of mounds makes manual interpretation and mapping a tedious process. We present a methodology that combines image segmentation and random forest spatial prediction with the aim to derive maps of carbonate mounds and an associated measure of confidence. We demonstrate our method based on multibeam echosounder data from Iverryggen on the mid-Norwegian shelf. We identified the image-object mean planar curvature as the most important predictor. The presence and absence of carbonate mounds is mapped with high accuracy. Spatially-explicit confidence in the predictions is derived from the predicted probability and whether the predictions are within or outside the modelled range of values and is generally high. We plan to apply the showcased method to other areas of the Norwegian continental shelf and slope where multibeam echosounder data have been collected with the aim to provide crucial information for marine spatial planning.
Shape and Size Complexity of Deep Seafloor Mounds on the Canary Basin (West to Canary Islands, Eastern Atlantic): A DEM-Based Geomorphometric Analysis of Domes and Volcanoes
Authors: Sánchez-Guillamón Olga , Fernández-Salas Luis , Vázquez Juan-Tomás , Palomino Desirée , Medialdea Teresa , López-González Nieves , Somoza Luis , León Ricardo
Published: January 2018

Derived digital elevation models (DEMs) are high-resolution acoustic technology that has proven to be a crucial morphometric data source for research into submarine environments. We present a morphometric analysis of forty deep seafloor edifices located to the west of Canary Islands, using a 150 m resolution bathymetric DEM. These seafloor structures are characterized as hydrothermal domes and volcanic edifices, based on a previous study, and they are also morphostructurally categorized into five types of edifice following an earlier classification. Edifice outline contours were manually delineated and the morphometric variables quantifying slope, size and shape of the edifices were then calculated using ArcGIS Analyst tools. In addition, we performed a principal component analysis (PCA) where ten morphometric variables explain 84% of the total variance in edifice morphology. Most variables show a large spread and some overlap, with clear separations between the types of mounds. Based on these analyses, a morphometric growth model is proposed for both the hydrothermal domes and volcanic edifices. The model takes into account both the size and shape complexity of these seafloor structures. Grow occurs via two distinct pathways: the volcanoes predominantly grow upwards, becoming large cones, while the domes preferentially increase in volume through enlargement of the basal area.
Groundwater Arsenic Contamination in the Ganga River Basin: A Future Health Danger
Authors: Chakraborti Dipankar , Singh Sushant , Rahman Mohammad , Dutta Rathindra , Mukherjee Subhas , Pati Shyamapada , Kar Probir
Published: January 2018

This study highlights the severity of arsenic contamination in the Ganga River basin (GRB), which encompasses significant geographic portions of India, Bangladesh, Nepal, and Tibet. The entire GRB experiences elevated levels of arsenic in the groundwater (up to 4730 µg/L), irrigation water (~1000 µg/L), and in food materials (up to 3947 µg/kg), all exceeding the World Health Organization’s standards for drinking water, the United Nations Food and Agricultural Organization’s standard for irrigation water (100 µg/L), and the Chinese Ministry of Health’s standard for food in South Asia (0.15 mg/kg), respectively. Several individuals demonstrated dermal, neurological, reproductive, cognitive, and cancerous effects; many children have been diagnosed with a range of arsenicosis symptoms, and numerous arsenic-induced deaths of youthful victims are reported in the GRB. Victims of arsenic exposure face critical social challenges in the form of social isolation and hatred by their respective communities. Reluctance to establish arsenic standards and unsustainable arsenic mitigation programs have aggravated the arsenic calamity in the GRB and put millions of lives in danger. This alarming situation resembles a ticking time bomb. We feel that after 29 years of arsenic research in the GRB, we have seen the tip of the iceberg with respect to the actual magnitude of the catastrophe; thus, a reduced arsenic standard for drinking water, testing all available drinking water sources, and sustainable and cost-effective arsenic mitigation programs that include the participation of the people are urgently needed.
Role of Disulfide Bonds in Activity and Stability of Tigerinin-1R
Authors: Chen Xiaolong , Hu Cuihua , Huang Yibing , Chen Yuxin
Published: January 2018

Tigerinin-1R (Arg–Val–Cys–Ser–Ala–Ile–Pro–Leu–Pro–Ile–Cys–His–NH2), a cationic 12-mer peptide containing a disulfide bond extracted from frog skin secretions, lacks antibacterial activity, but has the ability to stimulate insulin release both in vitro and in vivo. To study the structure–function relationships of tigerinin-1R, we designed and synthesized five analogs, including tigerinin-cyclic, tigerinin-1R-L4, tigerinin-linear, [C3K]tigerinin-1R, and [C11K]tigerinin-1R. Tigerinin-1R promoted insulin secretion in a concentration-dependent manner in INS-1 cells without obvious cytotoxicity. At a concentration of 10−5 M, [C11K]tigerinin-1R exhibited the highest stimulation ability, suggesting that the positive charge at the C-terminus may contribute to the in vitro insulin-releasing activity of tigerinin-1R. Tigerinin-1R peptides stimulated insulin release in INS-1 cells through a universal mechanism that involves mobilization of intracellular calcium without disrupting the cell membrane. In vivo experiments showed that both tigerinin-1R and [C11K]tigerinin-1R improved glucose tolerance in overnight-fasted mice. Due to its structural stability, tigerinin-1R showed superior hypoglycemic activity to [C11K]tigerinin-1R, which suggested a critical role of the disulfide bonds. In addition, we also identified a protective effect of tigerinin-1R peptides in apoptosis induced by oxidative stress. These results further confirm the potential for the development of tigerinin-1R as an anti-diabetic therapeutic agent in clinical practice.
Signaling by Steroid Hormones in the 3D Nuclear Space
Authors: Le Dily François , Beato Miguel
Published: January 2018

Initial studies showed that ligand-activated hormone receptors act by binding to the proximal promoters of individual target genes. Genome-wide studies have now revealed that regulation of transcription by steroid hormones mainly depends on binding of the receptors to distal regulatory elements. Those distal elements, either enhancers or silencers, act on the regulation of target genes by chromatin looping to the gene promoters. In the nucleus, this level of chromatin folding is integrated within dynamic higher orders of genome structures, which are organized in a non-random fashion. Terminally differentiated cells exhibit a tissue-specific three-dimensional (3D) organization of the genome that favors or restrains the activity of transcription factors and modulates the function of steroid hormone receptors, which are transiently activated upon hormone exposure. Conversely, integration of the hormones signal may require modifications of the 3D organization to allow appropriate transcriptional outcomes. In this review, we summarize the main levels of organization of the genome, review how they can modulate the response to steroids in a cell specific manner and discuss the role of receptors in shaping and rewiring the structure in response to hormone. Taking into account the dynamics of 3D genome organization will contribute to a better understanding of the pleiotropic effects of steroid hormones in normal and cancer cells.
Exploiting Multiple Detections for Person Re-Identification
Authors: Bhuiyan Amran , Perina Alessandro , Murino Vittorio
Published: January 2018

Re-identification systems aim at recognizing the same individuals in multiple cameras, and one of the most relevant problems is that the appearance of same individual varies across cameras due to illumination and viewpoint changes. This paper proposes the use of cumulative weighted brightness transfer functions (CWBTFs) to model these appearance variations. Different from recently proposed methods which only consider pairs of images to learn a brightness transfer function, we exploit such a multiple-frame-based learning approach that leverages consecutive detections of each individual to transfer the appearance. We first present a CWBTF framework for the task of transforming appearance from one camera to another. We then present a re-identification framework where we segment the pedestrian images into meaningful parts and extract features from such parts, as well as from the whole body. Jointly, both of these frameworks contribute to model the appearance variations more robustly. We tested our approach on standard multi-camera surveillance datasets, showing consistent and significant improvements over existing methods on three different datasets without any other additional cost. Our approach is general and can be applied to any appearance-based method.
Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment
Authors: Atkinson Stuart , Andreu Zoraida , Vicent María
Published: January 2018

Polymer therapeutics (PTs) provides a potentially exciting approach for the treatment of many diseases by enhancing aqueous solubility and altering drug pharmacokinetics at both the whole organism and subcellular level leading to improved therapeutic outcomes. However, the failure of many polymer-drug conjugates in clinical trials suggests that we may need to stratify patients in order to match each patient to the right PT. In this concise review, we hope to assess potential PT-specific biomarkers for cancer treatment, with a focus on new studies, detection methods, new models and the opportunities this knowledge will bring for the development of novel PT-based anti-cancer strategies. We discuss the various “hurdles” that a given PT faces on its passage from the syringe to the tumor (and beyond), including the passage through the bloodstream, tumor targeting, tumor uptake and the intracellular release of the active agent. However, we also discuss other relevant concepts and new considerations in the field, which we hope will provide new insight into the possible applications of PT-related biomarkers.
Durable Self-Cleaning Coatings for Architectural Surfaces by Incorporation of TiO2 Nano-Particles into Hydroxyapatite Films
Authors: Sassoni Enrico , D’Amen Eros , Roveri Norberto , Scherer George W. , Franzoni Elisa
Published: January 2018

To prevent soiling of marble exposed outdoors, the use of TiO2 nano-particles has been proposed in the literature by two main routes, both raising durability issues: (i) direct application to marble surface, with the risk of particle leaching by rainfall; (ii) particle incorporation into inorganic or organic coatings, with the risk of organic coating degradation catalyzed by TiO2 photoactivity. Here, we investigated the combination of nano-TiO2 and hydroxyapatite (HAP), previously developed for marble protection against dissolution in rain and mechanical consolidation. HAP-TiO2 combination was investigated by two routes: (i) sequential application of HAP followed by nano-TiO2 (“H+T”); (ii) simultaneous application by introducing nano-TiO2 into the phosphate solution used to form HAP (“HT”). The self-cleaning ability was evaluated before and after prolonged exposure to simulated rain. “H+T” and “HT” coatings exhibited much better resistance to nano-TiO2 leaching by rain, compared to TiO2 alone. In “H+T” samples, TiO2 nano-particles adhere better to HAP (having flower-like morphology and high specific surface area) than to marble. In “HT” samples, thanks to chemical bonds between nano-TiO2 and HAP, the particles are firmly incorporated in the HAP coating, which protects them from leaching by rain, without diminishing their photoactivity and without being degraded by them.
Review of Supported Pd-Based Membranes Preparation by Electroless Plating for Ultra-Pure Hydrogen Production
Authors: Alique David , Martinez-Diaz David , Sanz Raul , Calles Jose
Published: January 2018

In the last years, hydrogen has been considered as a promising energy vector for the oncoming modification of the current energy sector, mainly based on fossil fuels. Hydrogen can be produced from water with no significant pollutant emissions but in the nearest future its production from different hydrocarbon raw materials by thermochemical processes seems to be more feasible. In any case, a mixture of gaseous compounds containing hydrogen is produced, so a further purification step is needed to purify the hydrogen up to required levels accordingly to the final application, i.e., PEM fuel cells. In this mean, membrane technology is one of the available separation options, providing an efficient solution at reasonable cost. Particularly, dense palladium-based membranes have been proposed as an ideal chance in hydrogen purification due to the nearly complete hydrogen selectivity (ideally 100%), high thermal stability and mechanical resistance. Moreover, these membranes can be used in a membrane reactor, offering the possibility to combine both the chemical reaction for hydrogen production and the purification step in a unique device. There are many papers in the literature regarding the preparation of Pd-based membranes, trying to improve the properties of these materials in terms of permeability, thermal and mechanical resistance, poisoning and cost-efficiency. In this review, the most relevant advances in the preparation of supported Pd-based membranes for hydrogen production in recent years are presented. The work is mainly focused in the incorporation of the hydrogen selective layer (palladium or palladium-based alloy) by the electroless plating, since it is one of the most promising alternatives for a real industrial application of these membranes. The information is organized in different sections including: (i) a general introduction; (ii) raw commercial and modified membrane supports; (iii) metal deposition insights by electroless-plating; (iv) trends in preparation of Pd-based alloys, and, finally; (v) some essential concluding remarks in addition to futures perspectives.
Copper Bioleaching in China: Review and Prospect
Authors: Yin Shenghua , Wang Leiming , Kabwe Eugie , Chen Xun , Yan Rongfu , An Kai , Zhang Lei , Wu Aixiang
Published: January 2018

The commercial application of copper bioleaching, an environmentally-friendly approach for low-grade and secondary mineral resources recycling, has increased worldwide since the 2000s. As the world’s second-largest economic entity and the largest developing country, China has the largest demand for metal resources, significantly advancing the theory and industrial technology of copper bioleaching. This paper reviews the exploration and application of copper bioleaching in China. Two typical bioleaching applications and technological processes, bioheap leaching at the Zijinshan Copper Mine and bioheap leaching at the Dexing Copper Mine, are introduced. The considerable research completed by researchers is summarized, especially focusing on the isolation and identification of leaching bacteria, the bioleaching mechanism and interface reactions, multistage percolation behavior, bioleaching system reconstruction, the multiphysics coupled model, and enhanced copper bioleaching from waste printed circuit boards (WPCBs). Based on this investigation in China, key trends and prospects in copper bioleaching—such as efficiency improvement, environmental protection, and improved technology applications—are proposed.
Synthesis of Copper Sulfide Nanoparticles Using Biogenic H2S Produced by a Low-pH Sulfidogenic Bioreactor
Authors: Colipai Camila , Southam Gordon , Oyarzún Patricio , González Daniella , Díaz Víctor , Contreras Braulio , Nancucheo Ivan
Published: January 2018

The application of acidophilic sulfate-reducing bacteria (SRB) for the treatment of acidic mine water has been recently developed to integrate mine water remediation and selective biomineralization. The use of biogenic hydrogen sulfide (H2S) produced from the dissimilatory reduction of sulfate to fabricate valuable products such as metallic sulfide nanoparticles has potential applications in green chemistry. Here we report on the operation of a low-pH sulfidogenic bioreactor, inoculated with an anaerobic sediment obtained from an acid river in northern Chile, to recover copper via the production of copper sulfide nanoparticles using biogenic H2S. The laboratory-scale system was operated as a continuous flow mode for up to 100 days and the bioreactor pH was maintained by the automatic addition of a pH 2.2 influent liquor to compensate for protons consumed by biosulfidogenesis. The “clean” copper sulfide nanoparticles, produced in a two-step process using bacterially generated sulfide, were examined using transmission electron microscopy, dynamic light scattering, energy dispersive (X-ray) spectroscopy and UV-Vis spectroscopy. The results demonstrated a uniform nanoparticle size distribution with an average diameter of less than 50 nm. Overall, we demonstrated the production of biogenic H2S using a system designed for the treatment of acid mine water that holds potential for large-scale abiotic synthesis of copper sulfide nanoparticles.
Analytical Approaches to Improve Accuracy in Solving the Protein Topology Problem
Authors: Al Nasr Kamal , Yousef Feras , Jebril Ruba , Jones Christopher
Published: January 2018

To take advantage of recent advances in genomics and proteomics it is critical that the three-dimensional physical structure of biological macromolecules be determined. Cryo-Electron Microscopy (cryo-EM) is a promising and improving method for obtaining this data, however resolution is often not sufficient to directly determine the atomic scale structure. Despite this, information for secondary structure locations is detectable. De novo modeling is a computational approach to modeling these macromolecular structures based on cryo-EM derived data. During de novo modeling a mapping between detected secondary structures and the underlying amino acid sequence must be identified. DP-TOSS (Dynamic Programming for determining the Topology Of Secondary Structures) is one tool that attempts to automate the creation of this mapping. By treating the correspondence between the detected structures and the structures predicted from sequence data as a constraint graph problem DP-TOSS achieved good accuracy in its original iteration. In this paper, we propose modifications to the scoring methodology of DP-TOSS to improve its accuracy. Three scoring schemes were applied to DP-TOSS and tested: (i) a skeleton-based scoring function; (ii) a geometry-based analytical function; and (iii) a multi-well potential energy-based function. A test of 25 proteins shows that a combination of these schemes can improve the performance of DP-TOSS to solve the topology determination problem for macromolecule proteins.
Effects of Substitution, and Adding of Carbohydrate and Fat to Whey-Protein on Energy Intake, Appetite, Gastric Emptying, Glucose, Insulin, Ghrelin, CCK and GLP-1 in Healthy Older Men—A Randomized Controlled Trial
Authors: Giezenaar Caroline , Van der Burgh Yonta , Lange Kylie , Hatzinikolas Seva , Hausken Trygve , Jones Karen , Horowitz Michael , Chapman Ian , Soenen Stijn
Published: January 2018

Protein-rich supplements are used widely for the management of malnutrition in the elderly. We reported previously that the suppression of energy intake by whey protein is less in older than younger adults. The aim was to determine the effects of substitution, and adding of carbohydrate and fat to whey protein, on ad libitum energy intake from a buffet meal (180–210 min), gastric emptying (3D-ultrasonography), plasma gut hormone concentrations (0–180 min) and appetite (visual analogue scales), in healthy older men. In a randomized, double-blind order, 13 older men (75 ± 2 years) ingested drinks (~450 mL) containing: (i) 70 g whey protein (280 kcal; ‘P280’); (ii) 14 g protein, 28 g carbohydrate, 12.4 g fat (280 kcal; ‘M280’); (iii) 70 g protein, 28 g carbohydrate, 12.4 g fat (504 kcal; ‘M504’); or (iv) control (~2 kcal). The caloric drinks, compared to a control, did not suppress appetite or energy intake; there was an increase in total energy intake (drink + meal, p < 0.05), which was increased most by the M504-drink. P280- and M504-drink ingestion were associated with slower a gastric-emptying time (n = 9), lower ghrelin, and higher cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) than M280 (p < 0.05). Glucose and insulin were increased most by the mixed-macronutrient drinks (p < 0.05). In conclusion, energy intake was not suppressed, compared to a control, and particularly whey protein, affected gastric emptying and gut hormone responses.
Acrylated Chitosan Nanoparticles with Enhanced Mucoadhesion
Authors: Eliyahu Shaked , Aharon Anat , Bianco-Peled Havazelet
Published: January 2018

The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and nanoparticle yield. Chitosan (CS) nanoparticles, serving as a control, were fabricated using the same procedure. The mucoadhesion of the nanoparticles was evaluated using the flow-through method after different incubation periods. The retention percentages of ACS nanoparticles were found to be significantly higher than those of CS nanoparticles, for all studied time intervals. An additional indication for the increased mucoadhesion of ACS nanoparticles was the increase in particle size obtained from the mucin particle method, in which mucin and nanoparticles are mixed at different ratios. NMR data verified the presence of free acrylate groups on the ACS nanoparticles. Thus, the improved mucoadhesion could be due to a Michael-type addition reaction between the nanoparticles and thiol groups present in mucin glycoprotein, in addition to entanglements and hydrogen bonding. Overall, ACS nanoparticles exhibit enhanced mucoadhesion properties as compared to CS nanoparticles and could be used as vehicles for drug delivery systems.
Electrosprayed Core–Shell Composite Microbeads Based on Pectin-Arabinoxylans for Insulin Carrying: Aggregation and Size Dispersion Control
Authors: Rascón-Chu Agustín , Díaz-Baca Jonathan , Carvajal-Millan Elizabeth , Pérez-López Elías , Hotchkiss Arland , González-Ríos Humberto , Balandrán-Quintana Rene , Campa-Mada Alma
Published: January 2018

Aggregation and coalescence are major drawbacks that contribute to polydispersity in microparticles and nanoparticles fabricated from diverse biopolymers. This study presents the evaluation of a novel method for the direct, electrospray-induced fabrication of small, CaCl2/ethanol-hardened low methoxy pectin/arabinoxylans composite microbeads. The electrospray method was evaluated to control particle size by adjusting voltage, flux, and crosslinking solution content of CaCl2/ethanol. A bead diameter of 1µm was set as reference to test the capability of this method. Insulin was chosen as a model carried molecule. Statistical analysis was a central composite rotatable design (CCRD) with a factorial arrangement of 24. The variables studied were magnitude and particle size dispersion. For the determination of these variables, light diffraction techniques, scanning electron microscopy, transmission electron microscopy, and confocal laser scanning microscopy were used. Major interaction was found for ethanol and CaCl2 as well as flow and voltage. Stable spherical structures of core–shell beads were obtained with neither aggregation nor coalescence for all treatments where ethanol was included in the crosslinking solution, and the average diameter within 1 ± 0.024 μm for 11 KV, 75% ethanol with 11% CaCl2, and flow of 0.97 mL/h.
Spatial Vertical Directionality and Correlation of Low-Frequency Ambient Noise in Deep Ocean Direct-Arrival Zones
Authors: Yang Qiulong , Yang Kunde , Cao Ran , Duan Shunli
Published: January 2018

Wind-driven and distant shipping noise sources contribute to the total noise field in the deep ocean direct-arrival zones. Wind-driven and distant shipping noise sources may significantly and simultaneously affect the spatial characteristics of the total noise field to some extent. In this work, a ray approach and parabolic equation solution method were jointly utilized to model the low-frequency ambient noise field in a range-dependent deep ocean environment by considering their calculation accuracy and efficiency in near-field wind-driven and far-field distant shipping noise fields. The reanalysis databases of National Center of Environment Prediction (NCEP) and Volunteer Observation System (VOS) were used to model the ambient noise source intensity and distribution. Spatial vertical directionality and correlation were analyzed in three scenarios that correspond to three wind speed conditions. The noise field was dominated by distant shipping noise sources when the wind speed was less than 3 m/s, and then the spatial vertical directionality and vertical correlation of the total noise field were nearly consistent with those of distant shipping noise field. The total noise field was completely dominated by near field wind generated noise sources when the wind speed was greater than 12 m/s at 150 Hz, and then the spatial vertical correlation coefficient and directionality pattern of the total noise field was approximately consistent with that of the wind-driven noise field. The spatial characteristics of the total noise field for wind speeds between 3 m/s and 12 m/s were the weighted results of wind-driven and distant shipping noise fields. Furthermore, the spatial characteristics of low-frequency ambient noise field were compared with the classical Cron/Sherman deep water noise field coherence function. Simulation results with the described modeling method showed good agreement with the experimental measurement results based on the vertical line array deployed near the bottom in deep ocean direct-arrival zones.
An Efficient Direct Position Determination Method for Multiple Strictly Noncircular Sources
Authors: Yin Jiexin , Wang Ding , Wu Ying
Published: January 2018

This paper focuses on the localization methods for multiple sources received by widely separated arrays. The conventional two-step methods extract measurement parameters and then estimate the positions from them. In the contrast to the conventional two-step methods, direct position determination (DPD) localizes transmitters directly from original sensor outputs without estimating intermediate parameters, resulting in higher location accuracy and avoiding the data association. Existing subspace data fusion (SDF)-based DPD developed in the frequency domain is computationally attractive in the presence of multiple transmitters, whereas it does not use special properties of signals. This paper proposes an improved SDF-based DPD algorithm for strictly noncircular sources. We first derive the property of strictly noncircular signals in the frequency domain. On this basis, the observed frequency-domain vectors at all arrays are concatenated and extended by exploiting the noncircular property, producing extended noise subspaces. Fusing the extended noise subspaces of all frequency components and then performing a unitary transformation, we obtain a cost function for each source location, which is formulated as the smallest eigenvalue of a real-valued matrix. To avoid the exhaustive grid search and solve this nonlinear function efficiently, we devise a Newton-type iterative method using matrix Eigen-perturbation theory. Simulation results demonstrate that the proposed DPD using Newton-type iteration substantially reduces the running time, and its performance is superior to other localization methods for both near-field and far-field noncircular sources.
The Impact of Socio-Economic Indicators on Sustainable Consumption of Domestic Electricity in Lithuania
Authors: Vojtovic Sergej , Stundziene Alina , Kontautiene Rima
Published: January 2018

Lithuania is one of the EU Member States, where the rate of energy consumption is comparatively low but consumption of electricity has been gradually increasing over the last few years. Despite this trend, households in only three EU Member States consume less electricity than Lithuanian households. The purpose of this research is to analyse the impact of socio-economic factors on the domestic electricity consumption in Lithuania, i.e., to establish whether electricity consumption is determined by socio-economic conditions or population’s awareness to save energy. Cointegration analysis, causality test and error-correction model were used for the analysis. The results reveal that there is a long run equilibrium relationship between residential electricity consumption per capita and GDP at current prices as well as the ratio of the registered unemployed to the working-age population. In consequence, the results of the research propose that improvement of living standards for Lithuanian community calls for the necessity to pay particular attention to the promotion of sustainable electricity consumption by providing consumers with appropriate information and feedback in order to seek new energy-related consumption practices.
Three-Dimensional Finite Element Analysis of Maxillary Sinus Floor Augmentation with Optimal Positioning of a Bone Graft Block
Authors: Schuller-Götzburg Peter , Forte Thomas , Pomwenger Werner , Petutschnigg Alexander , Watzinger Franz , Entacher Karl
Published: January 2018

Purpose: the aim of the computational 3D-finite element study is to evaluate the influence of an augmented sinus lift with additional inserted bone grafting. The bone graft block stabilizes the implant in conjunction with conventional bone augmentation. Two finite element models were applied: the real geometry based bone models and the simplified geometry models. The bone graft block was placed in three different positions. The implants were loaded first with an axial force and then with forces simulating laterotrusion and protrusion. This study examines whether the calculated stress behavior is symmetrical for both models. Having established a symmetry between the primary axis, the laterotrusion and protrusion behavior reduces calculation efforts, by simplifying the model. Material and Methods: a simplified U-shaped 3D finite element model of the molar region of the upper jaw and a more complex anatomical model of the left maxilla with less cortical bone were created. The bone graft block was placed in the maxillary sinus. Then the von Mises stress distribution was calculated and analyzed at three block positions: at contact with the sinus floor, in the middle of the implant helix and in the upper third of the implant. The two finite element models were then compared to simplify the modelling. Results: the position of the bone graft block significantly influences the magnitude of stress distribution. A bone graft block positioned in the upper third or middle of the implant reduces the quantity of stress compared to the reference model without a bone graft block. The low bone graft block position is clearly associated with lower stress distribution in compact bone. We registered no significant differences in stress in compact bone with regard to laterotrusion or protrusion. Conclusions: maximum values of von Mises stresses in compact bone can be reduced significantly by using a bone graft block. The reduction of stress is nearly the same for positions in the upper third and the middle of the implant. It is much more pronounced when the bone graft block is in the lower third of the implant near the sinus floor, which appeared to be the best position in the present study.
Antimycobacterial Activity: A New Pharmacological Target for Conotoxins Found in the First Reported Conotoxin from Conasprella ximenes
Authors: Figueroa-Montiel Andrea , Bernáldez Johanna , Jiménez Samanta , Ueberhide Beatrix , González Luis , Licea-Navarro Alexei
Published: January 2018

Mycobacterium tuberculosis is the etiological agent of tuberculosis, an airborne infectious disease that is a leading cause of human morbidity and mortality worldwide. We report here the first conotoxin that is able to inhibit the growth of M. tuberculosis at a concentration similar to that of two other drugs that are currently used in clinics. Furthermore, it is also the first conopeptide that has been isolated from the venom of Conasprella ximenes. The venom gland transcriptome of C. ximenes was sequenced to construct a database with 24,284 non-redundant transcripts. The conopeptide was purified from the venom using reverse phase high performance liquid chromatography (RP-HPLC) and was analyzed using electrospray ionization-mass spectrometry (ESI-MS/MS). No automatic identification above the identity threshold with 1% of the false discovery rate was obtained; however, a 10-amino-acid sequence tag, manually extracted from the MS/MS spectra, allowed for the identification of a conotoxin in the transcriptome database. Electron transfer higher energy collision dissociation (EThcD) fragmentation of the native conotoxin confirmed the N-terminal sequence (1–14), while LC-MS/MS analysis of the tryptic digest of the reduced and S-alkylated conotoxin confirmed the C-terminal region (15–36). The expected and experimental molecular masses corresponded, within sub-ppm mass error. The 37-mer peptide (MW 4109.69 Da), containing eight cysteine residues, was named I1_xm11a, according to the current nomenclature for this type of molecule.
Prelude to village life. Environmental data and building traditions of the Epipalaeolithic settlement at Körtik Tepe, Southeastern Turkey
Authors: Benz Marion , Deckers Katleen , Rössner Corinna , Alexandrovskiy Alexander , Pustovoytov Konstantin , Scheeres Mirjam , Fecher Marc , Coşkun Aytaç , Riehl Simone , Alt Kurt W. , Özkaya Vecihi
Published: January 2018

Recent archaeological discoveries, refinements in genetic analyses and the archaeobotanical data require a reconsideration of the nature of the emergence of sedentary farming communities in Southeastern Turkey. In the rescue excavations prompted by the Batman and Ilısu dam projects several Early Holocene sites were discovered. For the first time, new data from Körtik Tepe now provide detailed evidence of a local Epipalaeolithic origin for these permanent settlements. In this article we summarize the results and analyses of the 2010-2012 excavations as well as palaeopedological and archaeobotanical data of the Younger Dryas layers at Körtik Tepe. Human isotope studies and the archaeological data suggest a permanent occupation of the site and might point to a local primordial adoption of a sedentary lifestyle in this region as early as the 11th millennium BC.
Anchoring of a dye precursor on NiO(001) studied by non-contact atomic force microscopy
Authors: Freund Sara , Hinaut Antoine , Marinakis Nathalie , Constable Edwin C , Meyer Ernst , Housecroft Catherine E , Glatzel Thilo
Published: January 2018

The properties of metal oxides, such as charge-transport mechanisms or optoelectronic characteristics, can be modified by functionalization with organic molecules. This kind of organic/inorganic surface is nowadays highly regarded, in particular, for the design of hybrid devices such as dye-sensitized solar cells. However, a key parameter for optimized interfaces is not only the choice of the compounds but also the properties of adsorption. Here, we investigated the deposition of an organic dye precursor molecule on a NiO(001) single crystal surface by means of non-contact atomic force microscopy at room temperature. Depending on the coverage, single molecules, groups of adsorbates with random or recognizable shapes, or islands of closely packed molecules were identified. Single molecules and self assemblies are resolved with submolecular resolution showing that they are lying flat on the surface in a trans-conformation. Within the limits of our Kelvin probe microscopy setup a charge transfer from NiO to the molecular layer of 0.3 electrons per molecules was observed only in the areas where the molecules are closed packed.
Evolution of Complex 3D Motions in Spicules
Authors: Sharma Rahul , Verth Gary , Erdélyi Robertus
Published: January 2018

Ubiquitous transverse oscillations observed in spicular waveguides, identified as the kink wave-mode had previously been reported along with periodic structural distortions of the flux tubes, observed as cross-sectional width and associated photometric variations. Previous studies identified these perturbations as the observed signatures of concurrent kink and sausage wave-modes. High-resolution Hα imaging-spectroscopy data from the CRisp Imaging SpectroPolarimeter at the Swedish Solar Telescope are used to analyze the off-limb spicular structures. For the first time, the evolution of the resultant transverse displacement of the flux-tube structure, estimated from the perpendicular velocity components, is analyzed along with longitudinal, cross-sectional width, photometric, and azimuthal shear/torsion variations. The pulse-like nonlinear kink wave-mode shows strong coupling with these observables, with a period-doubling, -tripling aspect, supported by mutual phase relations concentrated around 0° and

±
180
°

. The three-dimensional ensemble of the observed dynamical components revealed complexities pertinent to the accurate identification and interpretation of, e.g., linear/nonlinear, coupled/uncoupled magnetohydrodynamical wave-modes in spicules.