bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of cancer and alcohol use in patients with exocrine pancreatic insufficiency compared to patients with cystic fibrosis.
Authors: Peeples James , Gore James , Romo Karina G. , Noor Abdullah A. , Uwaifo Gabriel I.
Published: January 2024

680

Background: Cystic fibrosis (CF), the most prevalent genetic disorder among persons of European decent, is an autosomal recessive disorder due to CFTR gene mutations which lead to abnormally viscid exocrine secretions of the pancreas and other exocrine glands of the body. Exocrine pancreatic insufficiency (EPI) is a condition seen in ~85% of CF patients, in which the pancreas is unable to secrete adequate amounts of digestive enzymes. Although most patients with CF develop EPI, not all cases of EPI are caused by CF. Other risk factors for EPI include acute or chronic pancreatitis which may be triggered by alcohol, among other etiologies. Some studies suggest alcohol use as a possible independent risk factor for development of various cancers. Given these associations, we sought to characterize the prevalence of both alcohol use and cancer in patients with EPI vs patients with CF. Methods: A retrospective observational study was performed using electronic health records in Ochsner System, Louisiana, over a 3 year period: January 2017 to January 2020. Two cohorts were reviewed: patients with EPI excluding CF (n=596) and patients with CF (n=81). Results: While there was no significant difference in the prevalence of cancer at start vs end of the 3 year observation period in the CF cohort (4.1% at start, 7.2% at end), the prevalence of cancer was significantly greater among patients in the EPI cohort, both at start and end of the 3 year period: 15.95% at start, 43.9% at end (p <0.05). Also, while there was no significant change in alcohol use over the 3 year period for the CF cohort, the prevalence of alcohol use was significantly lower in CF cohort (0.45% at start, 2.2% at end) compared to EPI cohort which showed significant increase in alcohol use over the observation period: 7.7% at start vs 16% at end (p <0.05). Conclusions: There was a significantly higher prevalence of cancer in the EPI cohort compared to the CF cohort; while this may be due to higher prevalence of pancreatic cancer associated with EPI compared to CF, it does not explain the entirety of this observation. Not only was there a significantly higher prevalence of alcohol use in EPI cohort compared to CF cohort, but over the 3 year observation there was a 2-fold increase in prevalence of alcohol use within patients who already had a diagnosis of EPI. Within the EPI cohort, the observed increase in cancer prevalence and the increase in alcohol warrant further investigation into which factors unique to EPI patients without CF may modulate these social and health risk indices.
Association between TP53 gain of function and loss of function mutational subgroups and survival in pancreatic adenocarcinoma.
Authors: Zohar Nitzan , Blais Edik Matthew , Mueller Adam , Thach Dzung , de Arbeloa Patricia Miren , Matrisian Lynn McCormick , Petricoin Emanuel , Pishvaian Michael J. , Hendifar Andrew Eugene , Basu Mallick Atrayee , Lavu Harish , Yeo Charles J. , Bashir Babar , Nevler Avinoam
Published: January 2024

694

Background: TP53 is a commonly mutated tumor suppressor in pancreatic adenocarcinoma (PDAC) but the clinical implications for different classes of TP53 variants remain unclear. In contrast to loss of function (LOF) mutations, TP53 gain of function (GOF) mutations alter DNA conformational binding (e.g. R175H, G245S, R249S, R282H) or modify DNA contact hotspots (e.g. R248Q, R248W, R273H) and are associated with aggressive phenotypes. Here, we analyze progression-free survival (PFS) on standard therapies and overall survival (OS) of PDAC patients (pts) within TP53 mutational subgroups: GOF, LOF, and wild type (WT). Methods: We analyzed longitudinal outcomes across 775 pts with next generation DNA sequencing (NGS) results from Perthera’s Real-World Evidence database who received at least 1 line of therapy in the advanced setting for PDAC. PFS was evaluated from initiation of 1st line for advanced disease until discontinuation. Hazard ratios and p-values were computed via Cox regression when comparing OS relative to date of advanced diagnosis and PFS on subsets who received 1st line FOLFIRINOX (FFX) or 1st line gemcitabine/nab-paclitaxel (GA). Differences in frequencies of genomic alterations between TP53 mutational subgroups were analyzed by Fisher’s exact test. Results: In the TP53 LOF subgroup, median PFS on 1st line GA was significantly worse than 1st line FFX (Table) but this difference was not observed in TP53 GOF or WT subgroups. Irrespective of 1st line therapy choice, median OS in the WT subgroup (2.1y [1.8-2.4]) was significantly longer (p<0.05) than pts with TP53 GOF (1.5y [1.3-2.1]) or TP53 LOF (1.4y [1.3-1.5]). KRAS mutations were enriched (unadjusted p<0.05) for co-occurrence with TP53 in GOF (93.7%) and LOF (93.3%) subgroups relative to WT (74.5%). Mutations in BRCA1/2 were less common in the TP53 GOF subgroup (2.5%) relative to LOF (5.1%) and WT (11.6%). ATM mutations as well as an expanded set of genomic alterations within the DDR pathway were also enriched with similar trends (GOF<LOF<WT). Other potentially confounding factors will be discussed in the context of multivariate OS/PFS analyses. Conclusions: TP53 mutations correlated with worse prognosis in advanced PDAC. Potential predictive associations favoring FFX over GA in the TP53 LOF subgroup (but not in GOF or WT subgroups) warrant further exploration. [Table: see text]
Income and its impact on adenomatous neoplasms outcomes: An analysis of the National Cancer Database.
Authors: Nielsen Eric G. , Bine Christopher Reese , Lee Aron , Czaplicki Alec , Silberstein Peter T.
Published: January 2024

723

Background: Adenomatous neoplasmsof the small intestine are rare benign tumors but are occurring with increasing incidence. They exhibit a slight male predominance, with a median age of diagnosis in the 6th decade of life. The duodenum is the most frequent location of onset. Proposed environmental risk factors include high animal fat and protein diets, intestinal flora composition, and hereditary factors. Additionally, intestinal diseases, such as Crohn’s disease or Lynch syndrome, predispose individuals to develop small intestine adenomatous neoplasms. Despite this knowledge, no National Cancer Database (NCDB) research exists analyzing the association between survivability and income. Therefore, the objective of this study is to investigate overall survival rates among individuals with adenomatous neoplasms based on income levels. Methods: The NCDB was used to identify patients diagnosed with small intestine adenomatous neoplasms from 2004 to 2019 using the histology code 8140 as assigned by the Commission on Cancer Accreditation program. Kaplan-Meier, ANOVA Chi-Square tests were performed, and data were analyzed using SPSS version 27. Statistical significance was set at α = 0.05. Results: Of 19,582 patients included in the sample, 6,326 (30.8%) were from the highest income bracket, defined as annual income greater than $46,000, while 3,629 (24.4%) were from low-income brackets, defined as earnings less than $30,000. High-income patients experienced longer mean overall survival (58.5 months) compared to middle (49.7 months) and low (46.7 months) income patients (p<0.001). After controlling for age at diagnosis, sex, race, facility type, surgery status, adjunctive therapies, and insurance type, both the low- and middle-income brackets were associated with an independent increase in hazard (HR = 1.284 and 1.177 respectively; p<0.001). High income was associated with fewer comorbidities (72.2%) compared to low (65.9%) and middle-income (68.4%) patients (p<0.001). High-income patients were more likely to be treated at academic facilities (41.9%) compared to low (39.2%) or middle-income (35.4%) individuals (p<0.001), which have longer survivability (58.9 months vs. 47.8 months in non-academic facilities; p<0.001). Additionally, high income was also associated with increased rates of private insurance ownership (38.0%) while low-income individuals were more likely to have Medicaid (9.5%) or be uninsured (5.1%; p<0.001). No significant differences were found in tumor grade or differentiation, staging, metastasis, or surgical margins. Conclusions: This study indicates an association between high-income patients and increased survivability, while also observing an association with low-income and decreased survivability. Further research is required to assess specific environmental risk factors of adenomatous neoplasms and their relation to income level.
Effect of PD-1/ PD-L1 and statin combination therapy on gastrointestinal toxicity related to immune checkpoint inhibitors and on survival.
Authors: Wang Yinghong , Shah Jay Sanjay , Urias Rivera Andres Caleb , Mathew Antony , Thomas Anusha , Altan Mehmet , Zhao Dan
Published: January 2024

742

Background: Immune Checkpoint Inhibitor (ICI) therapy has greatly expanded its approval to treat a variety of malignancies with high efficacy. Inhibitors of programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) are two of the most common classes of ICI therapy. There has been significant research into medications that may have a synergistic effect with ICI therapy, notably statins due to their pro-apoptotic effect. The addition of statins to immunotherapy may also increase the risk of developing certain immune related adverse events (irAEs). We sought to investigate the effect of statin use on the development of gastrointestinal (GI) irAEs and on survival of patients on PD-1/L1 therapy. Methods: We conducted a review of select cancer patients at a tertiary cancer center who received PD-1/L1 inhibitors and statins between 2016 and 2022. The clinical characteristics and overall survival were compared to a control group who received PD-1/L1 inhibitors without statins. Results: A total of 823 patients were included in the statin group and compared to 11101 patients in the control group. In the statin group 707 received a PD-1 inhibitor, 86 received a PD-L1 inhibitor, and 30 received both checkpoint inhibitors. The included cancer types were lung cancer (44%), kidney cancer (26%), head/neck cancer (19%), and GI cancer (7.0%). The overall incidence of GI irAEs in patients receiving statins was 10.8%, which was comparable to patients without statin treatment (11.1%, p=0.83). In addition, statin treatment appeared to be associated with a more favorable survival in patients overall (p= 0.004) and also those with GI irAEs (p=0.047). Conclusions: Synergism between statins and PD-1/L1 inhibitors continues to be a developing field of interest. Our data showed the combination therapy’s survival benefit without exacerbating GI toxicity, which warrants further investigation of this treatment strategy.
First-line (1L) nivolumab (NIVO) + ipilimumab (IPI) in patients (pts) with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): 64-month (mo) follow-up from CheckMate 142.
Authors: Lenz Heinz-Josef , Overman Michael J. , Van Cutsem Eric , Limon Maria Luisa , Wong Ka Yeung Mark , Hendlisz Alain , Aglietta Massimo , Garcia-Alfonso Pilar , Neyns Bart , Gelsomino Fabio , Cardin Dana Backlund , Dragovich Tomislav , Shah Usman , McCraith Stephen , Wang Rui , Lei Ming , Yao Jin , Jin Lixian , Lonardi Sara
Published: January 2024

97

Background: NIVO + IPI demonstrated robust, durable clinical benefit and was well tolerated as a 1L therapy in pts with MSI-H/dMMR mCRC in the phase 2 CheckMate 142 study (NCT02060188), leading to the inclusion of NIVO + IPI in the NCCN guidelines as an initial therapy option for these pts. At 52-mo median follow-up, 1L NIVO + IPI continued to demonstrate durable clinical benefit, and no new safety signals were identified. Here we report longer follow-up results. Methods: Pts with MSI-H/dMMR mCRC and no prior treatment for metastatic disease received NIVO 3 mg/kg Q2W + IPI 1 mg/kg Q6W until disease progression or unacceptable toxicity. The primary endpoint was objective response rate (ORR) by investigator assessment (INV) per RECIST v1.1. Other key endpoints were disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), all by INV; overall survival (OS); and safety. Results: In total, 45 pts received 1L NIVO + IPI. With median follow-up of 64.2 mo (range, 59.4–68.9 mo), ORR by INV was 71% (95% CI, 56–84%). The proportion of pts with a best overall response of complete response (CR) was 20%, partial response (PR) was 51%, stable disease (SD) was 13%, and progressive disease was 16%. Median DOR (mDOR) was not reached, and the 60-mo DOR rate was 72%. Median PFS (mPFS) by INV and median OS (mOS) were not reached, with 60-mo PFS and OS rates of 55% and 67%, respectively (Table). Among pts alive at the data cutoff (n = 31), 30 remained treatment-free after initial study treatment without receiving any subsequent systemic therapy, with a median treatment-free interval of 34.7 mo (range, 1.6–61.4 mo). Exploratory analysis by tumor mutational burden status will be presented. Safety data are shown in the Table. Conclusions: At 64-mo follow-up, NIVO + IPI continued to demonstrate clinically meaningful survival and durable responses, with mPFS, mOS, and mDOR still not reached, suggesting the potential for long-term clinical benefit. Safety remained consistent with previous data. These findings further support current recommendations for NIVO + IPI as a 1L treatment for pts with MSI-H/dMMR mCRC. Clinical trial information: NCT02060188 . [Table: see text]
mFOLFIRINOX versus mFOLFOX 6 as adjuvant treatment for high-risk stage III colon cancer (FROST trial): Study protocol for an open label, multicenter, randomized, phase II study.
Authors: Lee Kyung-ha , Kim Ji Yeon , Yang In Jun
Published: January 2024

TPS230

Background: Patients with high-risk stage III colon cancer have a significantly poorer prognosis than those with stage II or low-risk stage III colon cancer. Despite this distinction, most guidelines recommend similar adjuvant treatment approaches for all stages, and there is a dearth of research focusing on high-risk stage III colon cancer and the potential for improved prognosis through more intensive adjuvant treatment. Given the proven efficacy of triplet chemotherapy in metastatic colorectal cancer, this study aims to assess the effectiveness and toxicity of modified 5-fluoropyrimidine (5-FU)/leucovorin plus irinotecan and oxaliplatin (mFOLFIRINOX) in comparison with the current standard of care—modified oxaliplatin and 5-FU (mFOLFOX-6)—as an adjuvant treatment for patients diagnosed with high-risk stage III colon cancer. Methods: This multicenter, randomized (1:1), open-label, phase II trial aims to compare the adjuvant treatment efficacy of mFOLFIRINOX and mFOLFOX-6 in patients with high-risk stage III colon cancer. The trial aimed to enroll 312 eligible patients aged between 20 and 70 years with an Eastern Cooperative Oncology Group performance status of 0-2, or between 70 and 75 years with an Eastern Cooperative Oncology Group performance status of 0. All patients underwent radical resection and were randomized into two arms: Arm A experimental arm, received 12 cycles of mFOLFIRINOX every 2 weeks, while arm B, the reference arm, received 12 cycles of mFOLFOX 6 every 2 weeks. The primary endpoint of this study was the 3-year disease-free survival, whereas the secondary endpoints included assessing the 3-year overall survival and treatment toxicity. Discussion: The Frost trial is expected to elucidate the safety and oncologic efficacy of mFOLFIRINOX compared to mFOLFOX 6 as adjuvant treatment for high-risk stage III colon cancers, and provide evidence about this treatment, and contribute to improve the prognoses ultimately. Clinical trial information: NCT05179889 .
Atezolizumab and bevacizumab in combination with TACE for patients with BCLC B HCC.
Authors: Stein Stacey , Cheng Wei , Wiess Christina , Pollak Jeffrey , Perez Lozada JuanCarlos , Chapiro Julius , Madoff David C.
Published: January 2024

TPS584

Background: The combination of atezolizumab and bevacizumab (AB) is an effective regimen for patients with advanced HCC1. Moving effective systemic therapy to earlier stages of HCC is a priority in improving outcomes. Assessing the safety of the combination of AB and TACE is essential to evaluating this regimen. Methods: This is an open-label, single arm pilot study. The primary objective of this study is to examine the safety and tolerability of AB with TACE. The secondary objectives are response rate, time to progression, overall survival, time to TACE progression (TTTP), and time to untaceable progression. Approximately 24 patients will be enrolled. AB will be given every 3 weeks (A: 1200 mg; 15 mg/kg) weeks and TACE will be planned for each patient to be completed in up to 4 treatments. B will be held for cycles that are within 4 weeks before or after each TACE. Imaging will be every 8 weeks for the first year, then every 12 weeks for the second year. Based on data from the GO30140 and the IMbrave 150 studies, we assume the rate of grade 3 or higher AEs is approximately 55% for AB and will likely be higher with the addition of TACE. Safety will be continuously monitored using the Bayesian Predictive Probability (PP) approach2. The PP that the rate of grade 3 or higher AEs is related to the combination is greater than 70% by the end of the trial based on toxicity data in the current stage will be continuously updated. Inclusion criteria includes patients over 18 years old with an ECOG PS of 0 or 1, no cirrhosis or Child-Pugh A cirrhosis, diagnosis of HCC by imaging or biopsy, and EGD within 6 months with no evidence of gastroesophageal varices with bleeding or high risk of bleeding unless treated. Patients are excluded if they are candidates for curative intent therapy, have had hepatic encephalopathy in the last 12 months, have occlusion of the hepatic artery or main portal vein, or have history of significant autoimmune disease. 1. Finn, Richard S., et al. New England Journal of Medicine 382.20 (2020): 1894-1905. 2 Lee J and Liu D. Clinical Trials. 2008; 5(2): 93-106. Clinical trial information: NCT05776875 .
Epidemiological characteristics of gastric and pancreatic cancers in Latin America: The LACOG 0222 GASPAR study.
Authors: Peixoto Renata D'Alpino , Diniz Gomes Diogo Bugano , Jesus Victor Hugo Fonseca , Weschenfelder Rui Fernando , Dias Jr Antonio Soares , Kruschewsky Coutinho Araujo Anelisa , de Jesus Rafaela Gomes , Rocha Matheus Soares , Gössling Gustavo Cartaxo de Lima
Published: January 2024

TPS710

Background: Gastric and pancreatic tumors remain among the cancers with the poorest prognoses in both high and low/middle-income countries. Data on the clinicopathological characteristics, standard treatments, and outcomes of these tumors are scarce in Latin America. This study is the first comprehensive effort to report epidemiological and clinical data in this region. Methods: The LACOG 0222 GASPAR trial ( NCT05924789 ) is a retrospective and prospective (bidirectional) observational cohort study. Enrollment of 200 patients across 15 sites in Latin America is planned, 120 patients in cohort A (gastric cancer) and 80 patients in cohort B (pancreatic cancer). No interventions are proposed. Eligibility criteria include age ≥18 years, histological diagnosis of gastric and gastroesophageal junction cancer (cohort A) or pancreatic cancer (cohort B), advanced disease diagnosis since January 2019, and availability of adequate medical data for data collection. The primary objective is to describe the clinical characteristics, treatment patterns, and outcomes of patients with gastric and pancreatic cancer in Latin America. Data on patients’ clinical characteristics, demographics, tumor pathological features, surgical therapy, radiotherapy, chemotherapy, and target therapy will be collected. Patient outcomes, such as recurrence-free survival, progression-free survival, and overall survival will also be collected. Patients will be followed up for up to 3 years after diagnosis. No a priori sample-size calculations were performed. The demographic and underlying disease characteristics will be evaluated using descriptive statistics. Time-to-event outcomes (disease-free survival, progression-free survival, and overall survival) will be estimated using the Kaplan-Meier method. From August 2023 to September 2023, 34 pts were included. The target accrual is expected to be completed by February 2024. The results are expected to be presented in August 2024.
A phase 1b/2 trial of pepinemab and avelumab as second line therapy for patients with metastatic pancreatic adenocarcinoma.
Authors: Hilty Bailey , Ruffolo Luis I. , Belt Brian A. , Byrne Matthew , Dave Yatee A. , Burchard Paul R. , Fisher Terrence Lee , Evans Elizabeth E. , Mallow Crystal L. , Boise Megan , Zauderer Maurice , Mulkerin Daniel , Yeh Jen Jen , Linehan David
Published: January 2024

TPS712

Background: Pancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related mortality with poor prognosis despite maximal therapy and is unresponsive to immune checkpoint blockade (ICB). This failure of response is hypothesized to be driven in part by the characteristic immunosuppressive tumor microenvironment. In PDAC, Semaphorin 4D (SEMA4D) expression is prognostic in patients who have undergone surgical resection and correlates with tumor infiltration of activated CD8+ T-cells. Additionally, preclinical models suggest that antibody-mediated SEMA4D blockade promotes tumoral infiltration and activation of CD8+ T-cells and sensitizes PDAC to ICB, with improved overall survival with standard of care chemotherapy and ICB in combination with pepinemab (humanized anti-SEMA4D). Thus, we hypothesized that pepinemab may improve clinical outcomes in PDAC by sensitizing tumors to ICB. Methods: We designed a phase Ib/II single-arm clinical trial to evaluate the safety, tolerability, and efficacy of humanized anti-SEMA4D (pepinemab) with anti-PD-L1 (avelumab) in patients with chemotherapy-refractory PDAC. Patients must have failed first-line 5-fluorouracil or gemcitabine-based combination chemotherapy. The study follows a dose de-escalation schema starting at a dose combination of 20mg/kg pepinemab and 800mg avelumab every two weeks. Patient accrual for phase 1b utilizes the Bayesian Optimal Interval Design (BOIN) targeting a dose-limiting toxicity rate of 30% or less. After 16 subjects receive a given combination dose, a Simon’s two stage assessment of futility will be undertaken with expansion to phase 2 if 2 or more subjects demonstrate response. The trial is designed to evaluate a total cohort of 40 subjects and powered to detect a response rate of 23% or greater, with alpha set at 0.1% and 80% power. Treatment response is assessed via RECIST 1.1 criteria with surveillance CT prior to enrollment and after completion of two cycles (8 weeks). Baseline and on-treatment tumor biopsies (after completion of one cycle, 4 weeks) are performed to analyze changes in immune, stromal, and genomic profiles to elucidate mechanisms of treatment response and failure. Patient reported outcomes are incorporated (FACT-Hep and FAACT subdomains) to assess disease-specific symptoms. To date, 7 patients have been enrolled (Clinical Trial NCT05102721). Clinical trial information: NCT05102721 .
Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules
Authors: Condello Vincenzo , Poma Anello M , Macerola Elisabetta , Vignali Paola , Paulsson Johan O , Zedenius Jan , Basolo Fulvio , Juhlin C Christofer
Published: January 2024

Background

Mutations in micro-RNA (miRNA) regulators DICER1 and DGCR8 have recently been uncovered, revealing a potential novel mechanism driving thyroid tumor development. However, the true frequency of these hotspot mutations in follicular-patterned thyroid tumors (FTs) and their relation to established driver gene events remain elusive.

Methods

A total of 440 FTs from 2 institutions were interrogated for DICER1, DGCR8, and RAS family hotspot mutations using Sanger sequencing. Whole-exome sequencing was also performed to identify additional driver gene aberrations in DICER1/DGCR8-mutant cases. Subsets of cases were further analyzed using miRNA expression profiling, and key dysregulated miRNAs were validated as markers of DICER1 mutations using quantitative RT-PCR analysis. The Cancer Genome Atlas (TCGA) database was also probed for DICER1/DGCR8 mutations and miRNA dysregulation.

Results

Fourteen (3.2%) and 4 (1%) FTs harbored DICER1 and DGCR8 hotspot mutations, respectively, in the combined cohort, and no cases with normal tissue available were found to exhibit a constitutional variant. Two DGCR8-mutant cases also harbored oncogenic RAS mutations. Whole-exome sequencing analysis did not identify additional driver gene events in DICER1/DGCR8-positive cases. Comprehensive miRNA expression profiling revealed a unique pattern of dysregulated miRNAs in DICER1/DGCR8-mutant cases compared with wild-type lesions. Moreover, DICER1-mutant cases showed a remarkable reduction of 5′ arm miRNAs, findings corroborated in the TCGA cohort.

Conclusion

DICER1 and DGCR8 hotspot mutations are rare in unselected cohorts of FTs, and mutated cases exhibit a specific miRNA profile. Although DGCR8 mutations may coexist with established RAS gene alterations, FTs with DICER1 variants were devoid of other driver gene events.
Between Shadows and Noise
Authors: Musser Amber Jamilla
Published: January 2024

In Between Shadows and Noise Amber Jamilla Musser theorizes sensation as a Black feminist method for aesthetic interpretation and criticism that uses the knowledges held by the body to access the unrepresentable. Thinking through Blackness, empire, and colonialism, Musser examines artworks ranging from Ming Smith's Flamingo Fandango, Jordan Peele's Us, and Katherine Dunham's Shango to Samita Sinha's This ember state, Titus Kaphar's A Pillow for Fragile Fictions, and Teresita Fernández's Puerto Rico (Burned) 6. She engages with these works from an embodied situatedness to grapple with the questions and sensations of racialization and difference that the works produce. Throughout, Musser rethinks how we consider the relationships between race, representation, and politics by dwelling in those spaces and concepts that elude Western norms of representation, objectivity, and logic. In so doing, she explores ways of being and knowing that exceed overdetermined parameters while offering a blueprint for sensing, imagining, and living otherwise.
Pathological and Ultrastructural Findings of Sphaerospora dicentrarchi (Myxosporea: Bivalvulida) infection in European seabass (Dicentrarchus labrax) farmed in Turkey
Authors: Birincioğlu SS , Avcı H , Ipek E , Berke E , Birincioğlu B , Aydogan A
Published: January 2024

Sphaerospora dicentrarchi is typically histozoic parasite of the wild and cultured European sea bass (Dicentrachus labrax) of the Mediterranean coastal countries. In this study, pathological and ultrastructural findings of the Sphaerospora dicentrarchi infection in European sea bass were firstly investigated in Turkey. For this purpose, the 862 European seabass (Dicentrarchus labrax L) were collected and evaluated from eight cultivation fish farms (offshore floating cages) in four different locations of Aegean Sea of Turkey (three farms from Kazıklı, one farm from Çandarlı, two farms from Taşburun and two farms from Güllük Regions). It was observed that the parasite was especially intense in adult fish and in the June-October period when the water temperature increased. Microscopically, the parasites were seen as the most intensive in the stomach, intestines, gall bladder, pancreas, heart and testis, respectively. Stomach was the most commonly infected organ. In the transmission electron microscopy examination, a bag-like group of mature couple spores were seen surrounded by polar capsules. As a result, it was determined that Sphaerospora dicentrarchi infection is very common in adult sea bass in the Aegean region of Turkey, as in Greece, Spain, Portugal and Italy.
Synovial Hemangioma of the Stifle Joint in a Kangal Dog
Authors: Dayı B , Sevimli A
Published: January 2024

A 10-year-old intact male Kangal dog presented with a mass located in the left stifle joint. The mass was 1.2x0.8x1 cm in size. Hematoxylin-eosin and immunohistochemical staining methods were used for histopathological evaluation. Histopathological examination revealed a significant proliferation in synoviocytes. Also, vascular channels lined with well-differentiated endothelial cells were detected. Immunohistochemically, mild CD31 expression was observed in the endothelial cells of the vascular channels. Actin expression was detected in smooth muscle cells of the vascular channels. In addition, vimentin expression was observed in the stromal connective tissue around blood vessels. Based on these findings, the mass was diagnosed as synovial hemangioma. In this case report, synovial hemangioma is rarely observed in animals has been reported.
Effect of microbial transglutaminase addition on reconstructed frozen rainbow trout (Oncorhynchus mykiss) meatballs’ quality
Authors: Kocatepe D , Corapci B , Altan CO , Kőstekli B , Turan H
Published: January 2024

In this study, MTGase (Control (without enzyme), A-0.5% MTGase (Group A), and B-0.8% MTGase (Group B) were added to rainbow trout meatballs at two different rates and the samples were stored at -18±1°C. The chemical (TVB-N, TBARS), physical (pH, water activity, color, texture, and cooking loss), microbiological (TMAB, TPAB, TYM, TCB, TAB, E. coli, and S. aureus), and sensory properties of the trout meatballs were examined for 210 days.

The TVB-N and TBARS values remained within the limit values during frozen storage. The pH and cooking loss values of the control group were different from those of Groups A and B. The water activity values generally remained stable. The L* and a* values were affected by the addition of MTGase. Moreover, the textural properties and sensory quality of the trout meatballs improved. During the frozen storage, the limit values were not exceeded in all groups, except for the TCB values.
Should Pre-Weaning Calf Diets Include Forage?
Authors: Muruz H , Aksu T
Published: January 2024

The present review article aimed to update and address the biological consequences of forage supply to pre-weaned dairy calves. Early growth and development of a calf play a great role in lifelong performance of the animal. Comprehension of these stages is an important progress achieved in calf nutrition today. Health, milk-solid feed intake and rumen development are the most important factors related to calf growth in pre- and post-weaning periods. It is well understood that fermentation by-products of grain-based starter feeds are essential for increased growth and absorptive capacity of the rumen papillae. In pre-weaned calves, two major hypotheses exist regarding forage feeding. The first hypothesis describes that the rumen was not completely developed in pre-weaned calves and forage supply during this period might increase gut fill and hence, decrease starter intake. It is believed that depressed starter intake may limit energy intake and finally suppress calf growth rate. The second hypothesis indicates that rumen pH may decline as calf age and starter intake increases. Accordingly, forage supplementation into calf starter diets could prevent further rumen pH decline and subsequent negative consequences while improving starter intake and calf growth. Because research data regarding these hypotheses are controversial, there is no universally accepted standard for feeding calves with forage as a part of starter diets. Many factors, such as milk feeding method, grain, forage type and experimental conditions, could affect calf response to dietary forage. However, there is an evidence that limited consumption of forage may be beneficial on rumen health and behavior of calves consuming highly processed (pelleted or finely ground) starter feed in pre-weaning period.

Keywords: Forage; Growth performance; Pre-weaned calf; Rumen development
The effects of mechanical ventilation on heart rate variability and complexity in mice
Authors: Kazdağli H , Ozel HF , Özbek MA
Published: January 2024

In a variety of diseases, altered respiratory modulation is often an early sign of autonomic dysfunction. Therefore, understanding and evaluating the effects of artificial ventilation on the autonomic nervous system is vital. The effects of artificial ventilation on autonomic balance have been assessed by heart rate variability using frequency domain and non-linear analysis including fractal complexity and entropy analysis in anesthetized mice. BALB/c mice (n=48) were divided into two groups: Spontaneous breathing and artificial ventilation. The electrocardiograms were recorded. Four different analyses were used: i. frequency domain analysis, ii. Poincaré plots, iii. DFA and iv. Entropy analysis. An unpaired t-test was used for statistical analysis. In a ventilated group, VLF and LF parameters were not changed, whereas the HF parameter was decreased compared to spontaneous breathing mice. DFAα1 was significantly increased due to artificial ventilation but DFAα2 was unchanged. SD2/SD1 ratio was increased, however, SD1 and SD2 were not significantly affected. Also, ApEn and SampEn remained unchanged. HF parameter, DFAα1, and SD2/SD1 were affected by artificial ventilation. Decreased HF and increased DFAα1, further support the notion that HRV is dominated by respiratory sinus arrhythmia at high frequencies, this may be due to decreased vagal tone caused by artificial ventilation.
Abnormal twinning in goat: a review
Authors: Pourlis A , Papakonstantinou G , Papatsiros V
Published: January 2024

A survey of congenital malformations relating to abnormal caprine twins was carried out. According to the degree, sites, and angle of fusion, they have various external variations and are classified as free asymmetric, conjoined symmetric or asymmetric twins (heteropagus or parasitic twins). The aim was to describe and summarize these defects. Among the recorded abnormal twining in goats, several common defects relate to thoraco-omphalopagus. A series of dicephali and diprosopus monsters have also been registered. At last, cases of free asymmetrical twins have been reviewed. There is also a report of a case of unequal conjoined–parasitic twins. The pathogenetic mechanisms of this condition, frequently reported in veterinary practice, are discussed. However, the etiopathogenesis of imperfect twins remains puzzling. The importance of embryonic duplications is commonly associated with dystocia. The manuscript finally introduces a framework of an essential national registry for the malformed companion animals.
Foundational principles of psychotherapy: A response to Al Mahrer
Authors: Dumont Frank
Published: January 2024

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Στάσεις απέναντι στην Ευρώπη και εθνική ταυτότητα
Authors: Γεώργας Δ. , Χαντζή Α. , Γκαρή Α. , Μυλωνάς Κ. , Ντάλλα Μ. , Ανδρεοπούλου Σ. , Παναγιωτοπούλου Π.
Published: January 2024

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Η διαπολιτισμική συμβουλευτική και ψυχοθεραπεία σε πρόσφυγες: Ψυχοκοινωνικές ανάγκες και πολιτισμικές διαφορές
Authors: Γιωτσίδη Βασιλική , Σταλίκας Αναστάσιος
Published: January 2024

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Η επίδραση του πλαισίου στην αναγνώριση οικείων προσώπων
Authors: Σουσαμίδου-Καραμπέρη Αικατερίνη
Published: January 2024

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Η συμβολή της φωνολογικής βραχύχρονης μνήμης στην απόκτηση λεξιλογίου
Authors: Μασούρα Ελβίρα , E. Gathercole Susan , Μπαμπλέκου Ζωή
Published: January 2024

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Επιδράσεις θυμικών και γνωστικών παραγόντων στον έλεγχο της δράσης
Authors: Παπαντωνίου Γεωργία , Ευκλείδη Αναστασία
Published: January 2024

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Οι διαταραχές της προσοχής στους φυσιολογικούς ηλικιωμένους, σε ηλικιωμένους με ήπια νοητική διαταραχή και σε ασθενείς με νόσο Alzheimer
Authors: Τσολάκη Μ. , Κουντή Φ. , Πέτκαρη Ε. , Κιοσσέογλου Γ. , Ξανθούλης Φ. , Κάζη Ε. , Διαμαντίδου Α. , Κάζης Α. , Ευκλείδη Α.
Published: January 2024

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Ψυχοδυναμική και γνωστική - συμπεριφορική συμβουλευτική για άτομα με προβλήματα υγείας: Σημεία σύγκλισης και απόκλισης
Authors: Ρούσση Παγώνα , Αυδή Ευρυνόμη , Τριλίβα Σοφία
Published: January 2024

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A historical approch to the identity development of counselling psychology
Authors: Stalikas Anastassios
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Affective expressions during joint attention interactions with an adult: The case of autism
Authors: Misailidi Plousia
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Η ελληνική Δοκιμασία Οπτικό-Νοητικής Ιχνηλάτησης: Προκαταρκτικές νόρμες για κλινική και ερευνητική εφαρμογή
Authors: Βλάχου Χριστίνα-Ελένη , Κοσμίδου Μαρία-Ελένη
Published: January 2024

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Επιθετικότητα και θυματοποίηση ανάμεσα στους μαθητές των ελληνικών Δημοτικών σχολείων
Authors: J. Boulton Michael , Καρέλλου Ιωάννα , Λανίτη Ιωάννα , Μανούσου Βασιλική , Λεμονή Ουρανία
Published: January 2024

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Ένα πρόγραμμα γνωσιακής - συμπεριφοριστικής ομαδικής παρέμβασης σε φοιτητικό πληθυσμό για την ενίσχυση των προσδοκιών αυτοαποτελεσματικότητας
Authors: Καλαντζή - Αζίζι Αναστασία , Χ. Καραδήμας Ευάγγελος , Σωτηροπούλου Γεωργία
Published: January 2024

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Η Ψυχολογία στην Ελλάδα: Παρελθόν, παρόν και σκέψεις για το μέλλον
Authors: Χουσιάδας Λάμπρος
Published: January 2024

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Γνωστικές επιτεύξεις και κοινωνική σκέψη: Αλληλεξάρτηση κατά την εφηβεία
Authors: Μαρκουλής Διομήδης
Published: January 2024

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Περιβαλλοντικά χαρακτηριστικά του σχολικού πλαισίου και οι επιπτώσεις τους στην αντίληψη
Authors: Συγκολλίτου Ευθυμία
Published: January 2024

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Θρησκευτική Σκέψη: Μια μελέτη για τη δομή, την ανάπτυξη και τις αλληλεπιδράσεις της με εξειδικευμένες γνωστικές ικανότητες
Authors: Πνευματικός Δημήτρης
Published: January 2024

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Μέτρηση της Ιδιοσυγκρασίας για ενήλικες με το Pavlovian Temperament Survey: Προκαταρκτικά ευρήματα για την ελληνική έκδοση και διαπολιτισμική αξιολόγηση
Authors: Καλαντζή - Αζίζι Αναστασία , Χριστακοπούλου Σοφία , Μυλωνάς Κώστας , Angleitner Alois , Strelau Jan
Published: January 2024

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Ανάλυση ερωτήσεων του ομαδικού τεστ νοημοσύνης ΑΗ4 της Heim στην Ελλάδα
Authors: Σ. Αλεξόπουλος Δημήτριος
Published: January 2024

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Η αρνητική ανάδραση ως παράγοντας και πηγή ιδιαιτερότητας: Από τη θεωρία του χάους σε νέες τάσεις στην ψυχολογική έρευνα
Authors: Γ. Παπαδόπουλος Νίκος , Σταμπουλίδης Παύλος
Published: January 2024

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Αξιοπιστία και εγκυρότητα του WISC-R για παιδιά ηλικίας έξι έως ένδεκα ετών στην Ελλάδα
Authors: Σ. Αλεξόπουλος Δημήτριος , Χαρίτου-Φατούρου Μίκα , Σακκά Δέσποινα , Σκαλτσάς Ανδρέας , Βλάχου Όλγα
Published: January 2024

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Ανομοιογένεια στις συμπεριφορές παιδιών που ανήκουν σε ομάδες διάφορων επιπέδων αποδοχής εκ μέρους των συνομιλήκων τους
Authors: Τριλίβα Σοφία , Chimienti Giovanni
Published: January 2024

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Introduction: The self as motive
Authors: Gonida Eleftheria , Metallidou Panayota , Dermitzaki Irini
Published: January 2024

ABSTRACT IS AVAILABLE IN THE PDF
Association of melatonin receptor 1 A with litter size in sheep: A review
Authors: Abuzahra Mutasem , Wijayanti Dwi , Effendi Mustofa Helmi , Mustofa Imam , Lamid Mirni
Published: January 2024

Sheep are a valuable livestock species worldwide, providing meat, milk, and various dairy products. This article aims to review the latest literature on the melatonin receptor 1A (MTNR1A) gene as a potential candidate gene associated with reproductive traits, particularly the litter size trait in sheep, by searching various databases for available literature. Studies have shown that different parts of the MTNR1A gene play various roles in sheep. By identifying marker genes associated with reproductive traits in MTNR1A polymorphisms linked to the litter size trait, breeders can achieve a faster selection response in sheep breeding by recognizing the genomic region where these genes are located and understanding their physiological functions. Therefore, highlighting the literature on these functions and their association with reproductive traits may contribute to improving the genetic makeup during sheep breeding.
Comparative evaluation of fracture resistance of re-attached teeth using self-adhesive bioactive flowable composite after preconditioning the fractured coronal fragments with different remineralizing agents
Authors: Rathod Pratik , Mankar Nikhil
Published: January 2024

One of the common forms of dental injury is anterior crown fractures, which mainly affects the teenagers and young adults. Fractures of the coronal portion of the permanent incisors characterize 18–22% of total traumatic injuries to dental hard tissues; of which 96% of them comprise the maxillary incisors. Uncomplicated fracture of crown is one of the most common types of dental traumatic injury. Dental trauma has an emotional impact on the patient’s overall health and can serious harm to the dentition. The treatment as well as prognosis of the fracture of coronal portion is a major challenge for a dentist because it has to accomplish various parameters like need to obtain an aesthetical result that approaches itself to its natural form and measurement, opaqueness and translucency of the original tooth structure in obtaining a effective restoration. It is suggested that reattachment of the fractured fragment is the best procedure for restoring an uncomplicated fracture of a crown, if a fragment is present. Reattachment of the fractured fragment offers major advantages over the conventional composite restoration. In reattachment, enhanced aesthetics is obtained because enamel’s true shape, colour, intensity, and surface texture are preserved. It re-establishes the major function and produces the favourable emotive and social response from the side of the patient. The reattached fragments are susceptible to further fracture when the restored teeth undergo further trauma. The resistance of the fractured teeth that has been reattached is the subject of the majority of concerns. Preconditioning the fractured fragments with remineralizing agents may aid in hydration. Thus, study will be conducted to evaluate the resistance of the fracture of a tooth that is reattached and pre-treated with remineralizing agents such as sodium fluoride and casein phosphopeptide-amorphous calcium phosphate and further reattached using one of the self-adhesive bioactive composite.
Migrant entrepreneurship support in Europe: a PRISMA systematic literature review
Authors: Polychronopoulos Dimitris , Nguyen-Duc Anh
Published: January 2024

Background This systematic literature review (SLR) analyzes migrant entrepreneurship support in Europe through three research questions (RQs) to understand 1) migrant entrepreneur characteristics in the European context, 2) challenges encountered by migrant entrepreneurs in European host countries, and 3) policies supporting migrant entrepreneurship in Europe. This review addresses gaps in current knowledge in academia as well as issues that policymakers and practitioners face when addressing migrant entrepreneurship support. Methods This SLR employed a search protocol to retrieve published sources from 1970 to 2021, via Scopus (27 March 2022) and Web of Science (7 April 2022). Inclusion criteria targeted migrant entrepreneurship support studies while exclusion criteria eliminated domestic migration and non-European contexts. The authors worked iteratively, aligning the data with the RQs to reduce bias, and adapted Bourdieu's forms of capital to create an analytical framework for the sources included in the SLR, with a table for each RQ to synthesize relevant data for analysis. Results The review examined 91 peer-reviewed papers, with a focus on migrant entrepreneurship support in Europe, covering characteristics, challenges, and support policies. It classified migrant entrepreneur challenges and characteristics into financial, human, and social capital, as well as external factors. Common challenges include the local culture and language, network, funding, and adapting to local business practices. Migrant entrepreneurs' stability relates to time in the host country and local language proficiency and reflects past entrepreneurial experience and education. Supportive mechanisms involve local networks, financing, and mentoring. Conclusions The SLR's limitations encompass possible oversight of pertinent studies, along with potential bias in data extraction, analysis, and subjectivity due to thematic analysis. Nonetheless, the findings suggest the following research agenda for migrant entrepreneurship support: evaluating and enhancing human and social capital, sharing information, designing support programs, addressing in-group/out-group bias in support programs, and exploring bottom-up migrant entrepreneurship support approaches.
Gaussian process models for geographic controls in phylogenetic trees
Authors: Hartmann Frederik , Jäger Gerhard
Published: January 2024

Geographical confounding in phylogenetic inference models has long been an issue. Often models have great difficulty detecting whether congruences or similarities between languages in phylogenetic datasets stem from common genetic descent or geographical proximity effects such as language contact. In this study, we introduce a distance-based Gaussian process approach with latent phylogenetic distances that can detect potential geographic contact zones and subsequently account for geospatial biases in the resulting tree topologies. We find that this approach is able to determine potential high-contact areas, making it possible to calculate the strength of this influence on both the tree-level (clade support) and the language-level (pairwise distances).
Technology and Disintermediation in Online Marketplaces
Authors: Gu Grace Y.
Published: January 2024

With the development of communication technology that makes online transactions easier, there is also an increased risk of disintermediation—sellers and buyers circumventing a platform to transact directly—in online two-sided marketplaces. Such disintermediation may lead to significant revenue loss for online platforms. However, it remains unclear how the characteristics of platforms affect their vulnerability to disintermediation. Using the blockade of Skype in mainland China as a natural experiment, this study examines how online communication technologies affect disintermediation and transaction outcomes in a large U.S. online freelance marketplace. The results show that restricting this alternative communication technology, which platforms struggle to monitor, reduces disintermediation by around 18%. This effect is potentially due to economic frictions in transactions, as the reduction in disintermediation is greater for high-transaction-cost jobs, such as time-sensitive jobs, communication-intensive jobs, and high-skilled jobs, as well as for cost-sensitive users, such as experienced users and personal users as opposed to enterprise users. With these results, platforms can reduce disintermediation risks when making investment and market entry decisions.

This paper was accepted by D. J. Wu, information systems.

Funding: This work was supported by the Strategic Management Society [SRF Dissertation Research Grant].

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02736 .