bluuebunny/crossref_metadata_2025 huggingface dataset:
Keselamatan dan Kesehatan Kerja dengan Kinerja Perawat
Authors: Febrianti Nur Andini , Yusmanisari Eka , Umami Siti Fithrotul
Published: December 2024

Keselamatan dan kesehatan kerja merupakan isu penting yang berkaitan erat dengan kinerja perawat di rumah sakit. Perawat merupakan salah satu staf utama yang memiliki kewajiban memberikan asuhan keperawatan, sehingga perawat juga memiliki resiko tinggi untuk mengalami cedera atau penyakit akibat kerja. Penelitian ini menggunakan metode analisis kuantitatif dengan pendekatan cross-sectional, yaitu untuk mengetahui hubungan antara varibel bebas dan variabel terikat. Dari 65 subjek, didapatkan hasil untuk keselamatan dan kesehatan kerja dengan mayoritas jawaban 47 subjek (72,3%) kategori cukup, dan kinerja perawat didapatkan hasil dengan mayoritas jawaban 39 subjek (60%) dengan kategori cukup. Hasil p-value sebesar 0,000<0,05 dengan nilai korelasi (r) yaitu 0,607 ditunjukkan oleh temuan uji statistik Spearman Rho dari studi kolerasi antar variabel, yang menunjukkan terdapat hubungan yang kuat. Dengan adanya penelitian ini, diharapkan bagi rumah sakit dapat menjadi evaluasi untuk mengambil langkah-langkah kedepannya, rumah sakit dapat memberikan tambahan dukungan dan fasilitas perawat untuk meningkatkan kinerjanya dalam bentuk pelatihan maupun pendidikan, perawat juga diharapkan dapat meningkatkan kinerjanya dan melaksanakan protokol dalam melaksanakan keselamatan dan kesehatan kerja di rumah sakit.
Data Tanaman Padi Di Kecataman Teras Kabupaten Boyolali
Authors: Diar Nurrochman Hilalal , Sulis Sulis Setiyo , Suci Lestariana Dwi
Published: December 2024

Tanaman Padi di Kecamatan Teras Kabupaten Boyolali memiliki potensi lahan luas untuk di kembangkan. Hal ini sebagai potensi untuk kesejahteraan masyarakat khususnya petani. Penelitian ini bertujuan untuk mengetahui hasil data akurat tentang tanaman padi diKecamatan Teras Kabupaten Boyolali dan mengetahui syarat tumbuh padi di Kecamatan Teras Kabupaten Boyolali. Metode penelitian  menggunakan data sekunder dengan cara mengambil data yang diinput oleh BPP (Balai Penyuluh Pertanian), yang terdiri dari 13 desa. Hasil penelitian menyatakan bahwa jumlah luas lahan panen di Kecamatan Teras dalam 1 tahun dari bulan Oktober 2018 sampai bulan September 2019 di 13 desa dalam kondisi baik  untuk menanam padi dengan letak 110o 22’ - 110o 50’ Bujur Timur dan 7o 36’ - 7o 71’ Lintang Selatan, ketinggian pada 159-250 mdpl, jenis tanah regosol engan pH antara 6,5-7,5 dengan tekstur tanah sebagian besar adalah remah, dan memiliki curah hujan 1.985,8 mm yang dimana hal tersebut masuk ke dalam syarat tumbuh bagi tanaman padi.
Masalah Hama Wereng pada Pertumbuhan Padi di Kabupaten Boyolali
Authors: Rifki Akbar Fauzi Ridho , Santoso Bagas , Lestariana Dwi Suci
Published: December 2024

Padi sudah tidak asing lagi bagi masyarakat Indonesia sebagai makanan pokok. Pesatnya kebutuhan akan hal tersebut dibutuhkannya peningkatan dari segi kualitas dan juga kuantitas. Penurunan jumlah produksi diakibatkan hama yang menyerang padi pada bagian pangkat batang sehingga malai mati dan berpengaruh pada bulir yang kosong sehingga mutu produksi berkurang. Tujuan peneitian ini adalah untuk mengetahui masalah hama pada tanaman padi yang terjadi pada musim pancaroba. Penilitian ini menggunakan metode survai yang di laksanakan pada masalah pertanian padi pada musim pancaroba di daerah desa nglembu, kecamatan sambi, kabupaten boyolali. Data yang di ambil dalam penelitian menggunakan data primer yaitu data yang didapat dari mewancarai langsung kepada petani di daerah sambi. Padi di sawah desa Nglembu, kecamatan Sambi. Pada musim pancaroba mayoritas petani padi di desa tersebut sedang mengalami masalah tentang hama yang menyerang tanaman padi. Serangan hama ini dapat menyebabkan gejala sundep pada tanaman padi sawah yaitu larva menyerang pangkal daun muda kemudian menjadi layu dan mengering. Ada beberapa tantangan yang di hadapi petani padi di Desa Nglembu, Kecamatan Sambi yaitu para petani yang kurangnya mengetahui jenis-jenis hama dan cara menanggulanginya, serta kurangnya pengetahuan tentang pengatasian setelah hama sudah di basmi. Solusi yang ditawarkan kepada petani yaitu penyemprotan hama menggunakan inseksida belt yang dapat mengendalikan hama sundlep dengan pengaplikasian 1 kali setelah terserang hama. Kerugian yang di sebabkan serangan hama dapat berupa penurunan jumlah dan mutu produksi Padi di desa Nglembu, kecamatan Sambi. Pada musim pancaroba mayoritas petani padi di desa tersebut sedang mengalami masalah tentang hama yang menyerang tanaman padi.
PENGARUH MODEL PEMBELAJARAN THINK PAIR SHARE TERHADAP HASIL BELAJAR AFEKTIF SISWA KELAS VII SMP NEGERI 14 KOTA BIMA
Authors: Rahmawati Anita , Suryani Erni , Nurfathurrahmah
Published: December 2024

Pendidik merupakan komponen yang mempengaruhi proses pendidikan yang harus diimbangi dengan kemampuan mengimplementasikan perangkat, media, srategi, metode maupun model pembelajaran. Salah satu model yang diterapkan adalah model pembelajaran think pair share. Hal ini bertujuan untuk membangun suasana belajar yang komunikatif antar siswa melalui saling berbagi informasi dalam kelompok. Hal ini didasari dari hasil observasi di kelas VII di SMP Negeri 14 Kota Bima bahwa hasil belajar Biologi siswa hanya terdapat 70% siswa belum mencapai ketuntasan. Hal ini menunjukan bahwa rendahnya hasil belajar siswa turut berpengarauh terhadap kurangnya keaktifan siswa mendominasi di kelas tersebut.
Jenis penelitian adalah quasi eksperimen. Terdiri dari kelompok kontrol siswa kelas VII A dengan jumlah 33 siswa menerapkan model diskusi dan kelompok eksperimen kelas VII B dengan jumlah 33 siswa menerapkan model Think pair share. Instrument untuk mengamati aktivitas belajar siswa menggunakan lembar observasi sesuai dengan aspek aktivitas. Berdasarkan hasil analisis data diperoleh ada perbedaan persentase keaktivan siswa yang signifikan antara kelas control dan eksperimen, sehingga disimpulkan Model pembelajaran think pair share berpengaruh terhadap hasil belajar afektif siswa kelas VII SMP Negeri 14 Kota Bima tahun ajaran 2022/2023.
MENINGKATKAN HASIL BELAJAR SISWA PADA MELALUI PENGGUNAAN MODEL PROJECT BASED LEARNING BERBANTUAN SICA BOX PADA KELAS V SDK DETUMBAWA
Authors: Pada Elisabet E. , Ritan Maria Natasha B. , Orang Yohanes Wiliber , Ledun Yustina B. , Abdullah Adi Neneng
Published: December 2024

Penelitian ini bertujuan untuk mengetahui penerapan model problem based learning (PBL).dalam meningkatkan hasil belajar peserta didik kelas V pada materi IPAS tentang Cahaya dan sifatnya berbantu media kotak sifat Cahaya ( SICA BOX) di SDK Detumbawa. Penelitian Tindakan kelas ini di lakukan selama dua siklus. Penilaian ini menunjukan bahwa terdapat peningkatan hasil belajar pada setiap siklus. Pada siklus 1 peserta didik yang tuntas adalah 10 orang atau presentase 66,67% sedangkan yang tidak tuntas adalah 5 orang atau presentase tidak tuntas 33,33%. Pada siklus II peserta didik yang tuntas adalah 13 orang dengan presentase 86,67 sedangkan yang tidak tuntas adalah 2 orang dengan presentase 13,33. Hal tersebut menunjukan hasil belajar peserta didik telah memnuhi indikator keberhasilan yaitu ≥70% . Dengan demikian model pembelajaran Problem Based Learning pada mata Pelajaran IPAS berbantu media kotak Cahaya atau SICA BOX terhadap hasil belajar peserta didik kelas V SDK Detumbawa dapat meningkat
Evaluación estructural de un letrero publicitario
Authors: Ceron Carballo Jesus Emmanuel , Caballero Garatachea Omar , Navarro Gómez Humberto Iván
Published: December 2024

La evaluación del comportamiento en sitio de una construcción destinada a un letrero publicitario para conocer su edad remanente, se basa en realizar un ensayo para determinar la resistencia ante eventos ambientales, tales como tempestades y movimientos dinámicos como sismos, impacto producto de lluvia con viento y de los efectos del clima, esto se logra realizando un estudio de la ubicación física de los nodos de la estructura. En este documento se presenta la evaluación del comportamiento mecánico de la armadura soporte cuando se combina con esfuerzos externos, encontrando resultados que demuestran variación del desplazamiento nodal en cuatro puntos de control, además, los desplazamientos lineales tridimensionales nodales cumplen con los criterios establecidos, encontrando desplazamientos menores a los máximos normativos con magnitud máxima de daño del 99.90 %, por consiguiente, cumplen con los criterios al límite de servicio.
Evaluación aproximada de la vida útil de vigas de concreto en ambientes costeros diseñadas conforme a la norma de concreto de la Ciudad de México
Authors: Barradas Hernández José Eriban , Vargas-Colorado Alejandro , Márquez-Domínguez Sergio , Carpio-Santamaría Franco Antonio , Piña-Flores José
Published: December 2024

El reglamento de construcciones públicas y privadas del municipio libre de Veracruz establece que, se debe utilizar la Norma Técnica Complementaria para el Diseño y Construcción de Estructuras de Concreto del Reglamento de Construcciones de la Ciudad de México vigente (NTC-Concreto, 2023) para realizar el diseño por durabilidad de los miembros de concreto reforzado (MCRs). Este diseño debe asegurar que los MCRs cumplan con un tiempo de vida útil de proyecto (TD) de 50 años. Dicha norma especifica un conjunto de requisitos prescriptivos y asume que los miembros alcanzarán el TD, aunque no proporciona un modelo de durabilidad para su verificación numérica. El objetivo de este documento es presentar la aplicación de un modelo de durabilidad para MCRs, según lo estipulado en la norma española de hormigón armado de 2008, la cual ha sido modificada mediante la inclusión de un coeficiente de difusión de cloruros que toma en cuenta el ancho de las grietas por flexión. Esto permitirá verificar numéricamente, de manera aproximada, el TD de una viga hipotética de concreto reforzado situada en un entorno exterior a 800 m de la costa del municipio de Veracruz, diseñada conforme a los lineamientos de las NTC-Concreto, 2023. Los resultados indican que la viga diseñada no cumple con el TD, lo cual no habría sido posible determinar sin la aplicación de este modelo de durabilidad modificado.
АРАБСКАЯ НАУКА И КУЛЬТУРА И ЕЕ ВЛИЯНИЕ
НА ЕВРОПУ В СРЕДНИЕ ВЕКА
Authors: Хатуев И.З. , Сугаипова А.М.
Published: December 2024

В статье авторы рассмотрели вопрос влияние арабской культуры на Европу в Средние века, поставили целью раскрыть основные достижения арабо-мусульманской культуры и науки в период средневековья, охарактеризовать влияние научных открытий арабских ученых на развитие научно-культурной жизни западноевропейских стран в период средневековья, раскрыть процесс заимствования европейцами основных успехов ученых Арабского Востока, выявить роль арабо-мусульманской цивилизации в развитии культуры и науки Европы.
Effect of Some Immunological Markers on The Level of Anti- Mullerian Hormone (AMH) in Women Infected with Toxoplasma gondii
Authors: Kadhim Salim , Mushattat Sukayna Jabbar , ALAridi Jabbar Abadi
Published: December 2024

Aim

Aims: To study effect of T. gondii infection on levels of immunological parameters for possible effects that may appear in infected women in the future, and to study direct correlation of infection in raising AMH value.

Material and methods

Materials and Methods: 80 blood samples were collected and divided into two equal groups. Of unmarried women, their ages ranged from 20-25: 1st group was from infected with Toxoplasma who visited health institutions, 2nd group was from whom were not infected as a control group. Toxoplasma infection was diagnosed using the LAT test and the ELISA test. Detection of human IL-2, IL-10 and IL-12 (pg/ml) ELISA KIT, Assay Max Human was conducted according to manufacturing company.

Results

Result: an increase in the level of human IL-2, IL-10 and IL-12 (pg/ml) in infected women compared to control group. A positive correlation of the human IL-2, IL-10 and IL-12 (pg/ml) with AMH level, which supports possibility of adopting AMH level as an indicator of cases of polycystic ovary cysts and infertility in future.

Conclusions

Conclusion: It was conducted to determine the relationship between the levels specific parameters such as IL-2, IL-12, and AMH and their effect on women with Toxoplasmosis, where the relationship was positive between the immune parameters, its levels increased in the event of infection, which increases possibility of using it as indicators of infection and also to predict the incidence of polycystic ovary syndrome or occurrence of infertility cases, there is a positive correlation between IL-2, IL-12 with level of AMH
Molecular Study of FAM20A Gene and Biochemical Analysis for Amelogenesis Imperfecta Patients
Authors: Ibraheem Mushtaq , Abdulrazaq Saif
Published: December 2024

Aim

Background: Amelogenesis Imperfecta uncommon hereditary dental disease is a collection of developmental disorders that impact the composition and clinical look of the enamel on all or almost all of the teeth in a roughly equal way. It may also be linked to morphologic or biochemical alterations in other parts of the body. Aims: This study aimed to diagnose Amelogenesis Imperfecta patients if have an isolated type or are related to a syndrome such as enamel renal syndrome.

Material and methods

Materials and methods: This case-control study included (60 patients and 20 controls). DNA extraction from the blood sample then used the Conventional PCR reaction and Agarose Gel Electrophoresis. The generated PCR fragments were subjected to Sanger sequencing. Geneious software showed the genotypes after aligning with a reference sequence in the Gene Bank. In addition, biochemistry analyses are performed by using a spectrophotometer.

Results

Results: The FAM20A gene was presented with three genotypes (TT, TC, CC) and two alleles (T and C), no significant variations were found. There was a positive correlation between the TT genotype with Amelogenesis Imperfecta; this means that patients whom caring TT genotype have a risk for Amelogenesis Imperfecta than other genotypes and non-significant relation regarding serum creatinine, potassium, and calcium while the serum urea and alkaline phosphatase have significant results.

Conclusions

Conclusion: patients who carry for TT genotype have a higher risk for Amelogenesis Imperfecta than other genotypes and no significant relation between creatinine, potassium, and calcium, while the serum urea and alkaline phosphatase show a significant relation
Novel pharmacologic approaches in resistant hypertension
Authors: Głuszek Jerzy
Published: December 2024

Resistant hypertension (RH) affects 10% to 18% of all patients with hypertension. It is diagnosed when blood pressure cannot be normalized despite the use of 3 classes of antihypertensive drugs (ACE inhibitors or sartans), calcium antagonists and diuretics in maximum doses. If the above-mentioned drugs are ineffective, spironolactone is most often administered. Recently, valsartan/sacubitrol and flozins have been increasingly used in resistant hypertension, which have been introduced for the treatment of diseases other than hypertension but can be a supplement to previously used drugs in resistant hypertension. Pharmaceutical companies are currently working on a dozen or so antihypertensive drugs. The most advanced studies concern aldosterone synthesis inhibitors, an endothelin receptor antagonist, and a drug that inhibits angiotensinogen synthesis. The results to date allow for the consideration of aprocitentan (a drug that inhibits endothelin receptors) or baxdrostat or another new aldosterone synthesis inhibitor in the treatment of resistant hypertension that does not respond to 4 drugs, including spironolactone. Further studies are needed to confirm the efficacy and safety of these new drugs in the treatment of resistant hypertension.
Penyuluhan Door To Door Bahaya Merokok dalam Ruangan di Kelurahan Ma’rang Kabupaten Pangkep
Authors: Amqam Hasnawati , Manyullei Syamsuar , Fikri Muh , Wandi Hanimusfira , Andryany Ririn , Alfrial Haikal Arsyah , Rahmadani Andi Azizah , Harsil Isma , Jayanti Andi Nova , Nathalinri Eirene
Published: December 2024

Bahaya merokok merupakan masalah yang belum bisa terselesaikan. Banyak dari individu yang menghirukan bahaya merokok bagi kesehatan. Merokok adalah satu-satunya penyebab ISPA yang paling penting. Merokok di dalam rumah menyebabkan seluruh ruangan tercemar oleh berbagai zat berbahaya dari asap rokok karena asap rokok dapat bertahan di udara dalam waktu yang cukup lama. Di Indonesia jumlah perokok pasif anak-anak sebanyak 43 juta anak. Anak-anak sangat rawan menjadi perokok pasif karena pernapasan anak-anak lebih banyak dibanding orang dewasa sehingga asap rokok dapat terhirup lebih banyak. Tujuan dari pengabdian ini adalah memberikan pemahaman dan kesadaran kepada masyarakat khususnya di Kelurahan Ma’rang akan penting bahaya merokok di dalam ruangan. Sasaran dari kegiatan ini yaitu masyarakat di Kelurahan Ma’rang yang berjenis kelamin laki-laki. Pengabdian ini dilakukan dengan metode door to door melalui penyuluhan menggunakan media leaflet. Hal tersebut dilihat dari peningkatan pengetahuan rata-rata pengetahuan responden yang sebagai pre-test lebih tinggi pengetahuannya dibanding responden post-test yang hanya memiliki rata-rata pengetahuan tinggi sebesar 26,7%. Kemudian dari data ini berpasangan maka digunakan uji Wilcoxon dapat dilihat bahwa nilai P-value sebesar 0,000 (<0,05) yang artinya bahwa terdapat skor rata-rata pengetahuan yang diberikan penyuluhan dan yang tidak sama sekali. Berdasarkan hasil tersebut, maka disimpulkan terjadi peningkatan pengetahuan terkait bahaya merokok dalam ruangan bagi masyarakat di Kelurahan Ma’rang.
Analisis Perawatan Mesin Uji Tarik Kapasitas 50 Ton dengan Metode Reliability Centered Maintenance (RCM) pada PT. BK
Authors: Fernanda Alif , Darajatun Rizki Achmad
Published: December 2024

This study applie the reliability Centered Maintenance (RCM) method to analyze the maintenance of tensile tensile testing machines at PT. BK. By collecting data on machine failures and reliability, the study conducts an analysis of failure causes and identifies critical failure mode. Based on the analysis, maintenance action are determined, including preventive maintenance, condition-based repairs, and the-based repairs. The effectiveness of these maintenance action is evaluated considering factors such as cost, time and impact on machine performance. The results of this study provide valuable insight fot planning optimal maintenance strategies of tensile testing machines, aiming to improve operational reliability, reduce downtime, and optimize maintenance cost.
Keywords: Downtime, Reliability Centered Maintenance, Tensile Tasting Machines
Pengendalian Kualitas dalam Perencanaan Produksi Menggunakan Alat Bantu Seven Tools di Perusahaan Konstruksi
Authors: Hermawan Fachrezi Rizki , Safariyani Eva
Published: December 2024

Increasingly fierce competition in the business world encourages companies to further develop ideas for effective and efficient ways to achieve predetermined goals. Many factors influence the success of achieving company goals. One of the most important forces that supports the achievement of company goals and increases company growth in the market is quality or quality score. Product or service quality control is critical to ensuring customer satisfaction and business success. One of the quality control tools is "Seven Tools" or Seven Quality Control Tools. The seven tools method is used for the production quality control process with the aim of solving various problems faced regarding the quality of a product. Types of defects found in cold room products at PT. There are 3 Pendawa Cipta Sakti, namely `: Glue doesn't stick, scratches on the coil, and holes in the styrofoam. Based on observations from graphs on histograms and Pareto diagrams, the most dominant type of defect is glue not sticking, therefore a cause and effect diagram for the type of defect glue not sticking is made.
Keywords: Manufacturing, Quality Control, Seven tools
Perancangan alat Penyiram Jagung Portabel Semi-Otomatis dalam Mendukung Pertanian Jagung Modern
Authors: Septiani Riana , Sundari Susanti , Hidayat Ghapur , Pratama Aam Wahyu
Published: December 2024

Corn farmers generally maintain corn plants by watering them with fertilizer or pesticides which is usually done with a device available on the market in the form of a tube connected by a hose to a spray stick to spray the solution onto the plants. Standard factory spray equipment on the market is difficult to use, ineffective and also inefficient. The use of a carrying sprayer is less effective in reaching corn plants that are almost the same as an adult's height, and human power still plays a very big role. The aim of this research is to make improvements to the design of spray equipment to correct the shortcomings of existing spray equipment. The French method used in this research is based on the effectiveness of this method in meeting data needs comprehensively when designing new products, it is very flexible and can be adapted to various types of products. This research succeeded in creating a design and prototype for a semi-automatic portable corn sprinkler. The state of the art from this research is that the design of this plant sprayer can be disassembled and installed to suit the size of the land and is very flexible, which is designed to support regional and national government programs for the welfare of corn farmers. The land area that can be watered by the new tool is wider, namely 200 m2 x 4 with a time of 2 hours;  Meanwhile, the tools sold on the market are still manual and can only water an area of ​​200 m2 x 2 for 4 hours.
Keywords: Corn plants ;Design ; Portable ; Sprayer
Pyrite depression by sodium metabisulfite and dextrin with xanthates: contact angle, floatability, zeta potential and IR spectroscopy studies
Authors: Corona-Arroyo Mario Alberto , López-Frías Karen Dioney , Solorzano Ramirez Karen Lizeth , Echeveste Vargas Cristina , Salazar-Hernández Ma Mercedes , Pineda-Urbina Kayim , Yang Bingqiao
Published: December 2024

The individual and combined depressive action of metabisulfite and dextrin on pyrite in the presence and absence of amyl xanthate has been studied through contact angle, zeta potential, microflotation, and IR spectroscopy analyses. The combined application of depressants significantly reduces the contact angle of pyrite compared with that of galena, with this effect being enhanced when the pulp is oxygenated during conditioning with metabisulfite, facilitating pyrite surface oxidation. Zeta potential measurements demonstrate the role of the oxidation process in decreasing the magnitude of the negative electric charge on the pyrite surface. These results were further corroborated by IR spectroscopy studies, which confirmed the oxidation of the pyrite surface in the presence of metabisulfite, as well as the co-adsorption of dextrin and amyl xanthate. In microflotation experiments, pyrite and galena exhibited contrasting flotation behaviors, with pyrite being effectively depressed at pH 8 when a combination of air, metabisulfite, and dextrin was used.
History Teachers' Efforts to Improve Learning Effectiveness by Optimizing Museums as Learning Resources
Authors: Dewi Sri Utami , Marcelli Fabio , Gibson Melody Kay
Published: December 2024

Purpose of the study: The purpose of this study is to determine how to optimize the function of the museum as a source of history learning at State Islamic High School 1 Probolinggo. The main purpose of the study is to optimize the function of this museum to increase the effectiveness of history learning. By optimizing the function of this museum, students can be more effective in learning history.
Methodology: This research on history teachers' efforts to improve learning effectiveness through optimizing the function of museums as learning resources at State Islamic High School 1 Probolinggo City is a qualitative descriptive research. A form of research aimed at describing existing phenomena, both natural phenomena and man-made phenomena. This research aims to obtain information and describe the results of the research.
Main Findings: This study specifically explores the role of history teachers in local history learning at State Islamic High School 1 Probolinggo. The focus on the contribution of history teachers to students' understanding of local history shows the uniqueness of this study in discussing important aspects of history learning. This study provides valuable insights into the role of history teachers in the context of local history learning, with a focus on integration, local resources, and the development of students' historical awareness.
Novelty/Originality of this study: this study not only identifies the role of museums as sources of historical learning, but also tries to measure and optimize its impact concretely in the context of historical learning at State Islamic High School 1 Probolinggo. This approach can provide a strong basis for further development in improving the effectiveness of historical learning in other schools.
Application of Natural Transform Decomposition Method for Solution of Fractional Richards Equation
Authors: Raghavendar K. , Pavani K. , Aruna K. , Okposo N. I. , Inc M.
Published: December 2024

This study employs the natural transform decomposition method (NTDM) to examine analytical solutions of the nonlinear time-fractional Richards equation (TFRE). The NTDM is an innovative and attractive hybrid integral transform strategy that elegantly combines the Adomian decomposition method and the natural transform method. This solution strategy effectively generates rapidly convergent series-type solutions through an iterative process involving fewer calculations. The convergence and uniqueness of the solutions are presented. To demonstrate the efficiency of the considered solution method, two test cases of the TFRE are investigated within the framework of the Caputo-Fabrizio and Atangana-Baleanu-Caputo derivatives whose definitions incorporate nonsingular kernel functions. Numerical comparisons between the obtained approximate solutions, exact solutions, and those from existing related literature are presented to show the validity and accuracy of the technique. Graphical representations demonstrating the effect of varying non-integer, temporal, and spatial parameters on the behavior of the obtained model solutions are also presented. The results indicate that the execution of the method is straightforward and can be employed to explore complex physical systems governed by time-fractional nonlinear partial differential equations.
Synthesis and Anti-Anxiety Activity of Some 1-Piperazino Derivatives of 2, 4-Diphenyl 2, 3-Dihydro-1, 5-Benzodiazepine
Authors: Chatterjee N.R. , Chandak B.G. , Jadhav G.R. , Sharma D.C.
Published: December 2024

Halogenation reaction of 2-methyl, 2, 4- diphenyl-1H-1, 5-benzodiazepine (1) with thionyl chloride gave the N-chloro derivative(2) which on condensation with 4- substituted piperazines afforded the title compounds (3) which were characterized by analytical and spectral data. All these compounds (3a-c) showed significant anti-anxiety activity against diazepam as a standard by elevated plus maze method.
3D QSAR Studies on a Series of 4-Anilino Quinazoline Derivatives as Tyrosine Kinase (EGFR) Inhibitor: The k-Nearest Neighbor Molecular Field Analysis Approach
Authors: Noolvi Malleshappa N. , Bhardwaj Varun , Patel Harun M.
Published: December 2024

Epidermal growth factor receptor (EGFR) protein tyrosine kinases (PTKs) are known for its role in cancer. Quinazoline have been reported to be the molecules of interest, with potent anticancer activity and they act by binding to ATP site of protein kinases. ATP binding site of protein kinases provides an extensive opportunity to design newer analogs. With this background, we report an attempt to discern the structural and physicochemical requirements for inhibition of EGFR tyrosine kinase. The k-Nearest Neighbor Molecular Field Analysis (kNN-MFA), a three dimensional quantitative structure activity relationship (3D- QSAR) method has been used in the present case to study the correlation between the molecular properties and the tyrosine kinase (EGFR) inhibitory activities on a series of quinazoline derivatives using SW, SA and GA variable selection method. kNN-MFA calculations for both electrostatic and steric field were carried out. The master grid maps derived from the best model has been used to display the contribution of electrostatic potential and steric field. The statistical results by SW variable selection method has shown significant correlation coefficient r2 (q2) of 0.9141, r2 for external test set (pred_r2) 0.8033, coefficient of correlation of predicted data set (pred_r2se) of 0.7845, and k nearest neighbor of 2.Therefore, this study not only casts light on binding mechanism between EGFR and its inhibitors, but also provides hints for the design of new EGFR inhibitors with observable structural diversity.
Anti-tumour Activity of 1, 3- Dimethyl Acridones Against Ehrlich Ascites Carcinoma
Authors: Sathish N.K , N.M. Raghavendra , Mohammed Irfan ali
Published: December 2024

We report here in vitro and in vivo antitumour activity study of a series of 1,3-dimethyl-N10 substituted acridone derivatives. All the molecules have been designed on the basis of the presence of specific recognition patterns consisting of electron donor, carbons. Chloro groups with precise spatial separation and structural features (lipophilicity, positive charge at neutral pH and presence of aromatic rings). In vitro and in vivo antitumour effects have been demonstrated against EAC cell-lines. Compounds 2,7,8,9,12,13,14 and 15 exhibited good antitumour activity when compared to Vincristine and compound 14 (β-hydroxy ethyl) piperazine derivative with four carbon spacer exhibited good antitumour activity.
Microwave Assisted Synthesis and 3D QSAR Analysis of Analgesic Oxadiazoles
Authors: Sawant Ramesh L. , Lanke Prashant D
Published: December 2024

In present work we report design, synthesis and evaluation of the analgesic activity of new 2, 5-disubstituted1, 3, 4-oxadiazoles. An ecofriendly method for the conversion of substituted benzoic acid hydrazides to 2, 5-disubstituted1, 3, 4-oxadiazoles in the presence of phosphorous oxychloride under the influence of microwave irradiation and conventional route has been described. The structures of oxadiazoles formed were confirmed by elemental and spectral analysis. In comparison with conventional microwave assisted method is simple, rapid and efficient. The title compounds were tested for analgesic activity by tail flick method and the series of 20 compounds was subjected for 3D QSAR analysis using V life MDS 3.5 software. The compounds were divided into training and test set. Best QSAR model was selected on the basis of various statistical parameters like square correlation coefficient (r2), cross validated square correlation coefficient (q2), standard error of estimation (SE) and sequential Fischer test (F). 3D QSAR study reveals that electronegative and bulk substitution at second and fifth position of 1, 3, 4-oxadiazole improves the analgesic activity.
Synthesis of 5-substituted-3-methylsulfanyl-1-(2,4-dinitro phenyl)- 1H-pyrazole-4-carboxylic Acid Ethyl Esters as New Analgesic and Anti-inflammatory Agents
Authors: Gokulan P.D. , B. Jayakar
Published: December 2024

A new series of 5-substituted-3-methylsulfanyl-1-(2,4-dinitro phenyl)-1H-pyrazole-4-carboxylic acid ethyl esters were synthesized by reacting the amino group of 5-amino-3-methylsulfanyl-1-(2,4-dinitro phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester with acid anhydrides, acid chlorides and phenyl dithiocarbamates. The title compounds were investigated for analgesic, anti-inflammatory and ulcerogenic behaviour. The compound 5-benzoylamino-3-methylsulfanyl-1-(2,4-dinitro phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester (3c) emerged as the active compound and exhibiting imperative analgesic and anti-inflammatory activity. Interestingly the test compounds showed only mild ulcerogenic potential when compared to indomethacin
Investigation of 1, 3, 4-Oxadiazole Scaffold as Potentially Active Compounds
Authors: Somani Rakesh R. , Agrawal Anuj G. , Kalantri Pushkar P. , Gavarkar Pratibha S. , Clercq Erik De
Published: December 2024

In the present work, various Schiff’s bases of isoniazid bearing 1, 3, 4-oxadiazole nucleus were synthesized. These compounds were purified, characterized and evaluated in vitro for antibacterial, antifungal and antiviral activities. Compound 5 showed better biological profile.
QSAR Modeling of Substituted Benzimidazole Derivative as Angiotensin II-AT1 Receptor Antagonist: WHIM Descriptors
Authors: Vyas Vivek K , Ghate Manjunath
Published: December 2024

Selective inhibition of Angiotensin II (Ang II) is an important strategy for design of Ang II-AT1 receptor antagonist which is devoid of the common side effects of angiotensin converting enzyme inhibitors (ACEIs). QSAR study of 4, 5, 6, and 7 substituted benzimidazole analogs were performed using Dragon 2.1 (Milano Chemometrics) for antagonism of Ang II. The study was carried out on 33 compounds; mathematical models were obtained by means of the sequential multiple linear regression analysis (SMLR). QSAR analysis have produced good predictive models and give statistically significant correlations of selective Ang II antagonism with WHIM descriptors concerning size, symmetry, shape and distribution of molecules atom. The predictive ability of the resulting QSAR model was evaluated by cross validated correlation coefficient (q2 = 0.659). It was able to describe more than 68% of the variance in the experimental activity. This QSAR study helps in design and prediction of Ang II inhibitory activity of novel substituted benzimidazole Ang II-AT1 receptor antagonist.
Discovery of New Imidazolinones Derivatives as Potential Microbial Agents
Authors: Patel Jitesh B , Desai Vikas A
Published: December 2024

A series of imidazolinone were prepared by heating the hippuric acid in presence of acetic anhydride and sodium acetate with different aromatic aldehydes gave 5-oxazolone derivatives which reacting with N-amino-2,3,4,5,6-pentafluoro benzamide in pyridine gave imidazolinone. All the synthesized compounds have been characterized on the basis of elemental analysis, IR, 1H-NMR and 13C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of the compound was endowed with a remarkable antibacterial as well as antifungal activity.
Lead Discovery and Lead Optimization: A Useful Strategy in Molecular Modification of Lead Compound in Analog Design
Authors: Patidar Ashutosh Kumar , G Selvam , M Jeyakandan , Mobiya Ashok Kumar , Bagherwal Ajay , Sanadya Gaurav , Mehta Ramraj
Published: December 2024

The current trend in the drug design is to develop new clinically effective agents through the molecular modification of a lead nucleus. A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity. Lead optimization is the synthetic modification of a biologically active compound, to fulfill all stereoelectronic, physicochemical, pharmacokinetic and toxicologic required for clinical usefulness. The main objective of this review is to discuss the methods of lead discovery, lead optimization and its role in molecular modification of lead compound in analog design.
Design and Synthesis of 1-(2-amino-1-(4-methoxyphenyl)ethyl) cyclohexanol Analogs as Potential Microbial Agents
Authors: Mahyavanshi Vinay , Marjadi Sunil I.
Published: December 2024

1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol (1), on condensation with chloroacetyl chloride yielded 2-chloro-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamide (2), which on amination with hydrazine hydrate yielded in turn 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamide (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-(2-benzylidenehydrazinyl)-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamides 4a-n, which upon dehydrative annulation in the presence of chloroacetyl chloride and triethylamine yielded 2-(3-chloro-2-oxo-4-phenylazetidin-1-ylamino)-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl) acetamides 5a-n. The synthesized compounds 4a-g and 5a-g were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (Gram positive), Bacillus subtilis (Gram positive), Pseudomonas aeruginosa (Gram negative) and Escherichia coli (Gram negative). They were found to exhibit good to moderate antibacterial activity. The antifungal activities of these compounds were also tested against three different fungal species. None of them were active against the species tested.
Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Azetidinones from Dehydroacetic Acid
Authors: Pulate Chetan P. , P. M. Gurubasavrajswamy , Antre Rishikesh V , Goli Divakar
Published: December 2024

This paper describes the reaction of dehydroacetic acid with primary aromatic amines to yield Schiff bases (2a-2g) by using microwave system. Schiff bases irradiated with dimethyl formamide in presence of triethyl amine and chloroacetyl chloride to afford azetidinones (3a-3g) in excellent yields. The products, characterized on the basis of spectral data, have shown moderate to good antimicrobial activity against some bacteria and fungi.
Synthesis Antimicrobial Activity and Chemotherapeutic Potential some Novel Benzimidazole Derivatives
Authors: Jain Priyal , Jain Vaibhav , Jain Abhishek K , Singour Pradeep K
Published: December 2024

Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. With the purpose of finding new chemical entities with enhanced antimicrobial activity, a series comprises 2-substituted-5-nitro benzimidazole derivatives were synthesized. Investigation of antimicrobial activity of the compounds was done by disc diffusion method using Gram-positive (S. aureus, S. mutans and B. subtilis), Gram-negative (E. coli, S. typhi and P. aeruginosa) bacteria. Some derivatives showed remarkable activity comparable to that of standard against Gram-positive and Gram-negative bacteria.
FORMATION OF A CULTURE OF INTERETHNIC COMMUNICATION IN THE YOUTH ENVIRONMENT
Authors:   Altai State Pedagogical University, Ponomarenko O. P.
Published: December 2024

The article analyzes approaches to solving the problem of interethnic relations in the territory of the Russian Federation. Pedagogical techniques in the formation of a culture of interethnic relations in the student environment of the university are considered. The variants of creative tasks aimed at improving the general cultural level of students are offered
CONSIDERATION OF THE PRINCIPLES OF BILINGUAL LANGUAGE EDUCATION IN TEACHING RUSSIAN IN THE REPUBLIC OF KAZAKHSTAN
Authors:   Municipal state institution “Secondary school No. 19 named after Bular batyr”, Hijurova A. H.
Published: December 2024

The paper presents the principles of bilingual education that must be taken into account in teaching Russian to bilingual schoolchildren in the Republic of Kazakhstan. Russian Russian language teaching in a bilingual educational environment, the definition of the current state and approaches to teaching in a bilingual learning environment, optimal methods and techniques for teaching Russian in a bilingual educational environment should contribute to improving the work of a Russian language teacher in a national school.
SUSTAINABILITY OF IMAGES IN CHILDREN’S WORK AS AN INDICATOR THEIR ARTISTIC AND MORAL DEVELOPMENT
Authors:   Magnitogorsk State Technical University named after. G. I. Nosova, Khripunova E. A.
Published: December 2024

Тhe article describes the experience of forming the artistic, imaginative and moral qualities of children through stable images of the Ural tale. The objects of study were the works of professional artists and children aged 6 to 17 years illustrating the tale of the Ural writer and publicist P.P. Bazhova. The author highlighted the commonalities and features in the illustrations of professionals and schoolchildren. This article is intended for fine arts teachers.
MODERNIZATION OF THE PROFESSIONAL TRAINING OF PRIMARY SCHOOL TEACHERS IN A MULTICULTURAL SOCIETY
Authors:   Kaluga State University, Biba A. G.
Published: December 2024

The article examines the professional training of primary school teachers to work with bilingual and foreign-speaking children in a mass school. Based on the analysis of the theoretical provisions of teacher training, pedagogical psychology, psycholinguistics, and teaching methods, the components of the readiness of primary education teachers to work in a multilingual classroom are highlighted, taking into account their axiological, socio-cultural, psychological, pedagogical and methodological problems. By the empirical study conducted by the authors of the joint education of Russian-speaking primary school children and foreign speakers and the preparation of future teachers for the organization of this process, the content and methods of ensuring the appropriate readiness of primary education teachers in the process of their normative theoretical and practical training are clarified.
METHODOLOGICAL AND TECHNOLOGICAL FOUNDATIONS FOR STUDENTS TO CONDUCT RESEARCH WORK ON PHYSICAL EDUCATION AND HEALTH TOPICS
Authors:   Altai State Medical University, Wegner O. S. , Polotnyanko K. E. , Terentyev M. S.
Published: December 2024

In Russian universities, independent research work of students is provided at different levels - in scientific student circles and, ultimately, in the preparation of final qualifying works of senior students. At departments, teachers responsible for the work of scientific student circles provide students with initial, basic knowledge for conducting their research. Such knowledge includes: the choice of scientific research methodology and technology for conducting research. A scientific and pedagogical approach to mastering the specified knowledge is shown at the Department of Physical Culture and Healthy Lifestyle at the Altai State Medical University (ASMU).
FORMATION OF AESTHETIC TASTE THROUGH ARTISTIC CREATIVITY OF PRESCHOOL CHILDREN
Authors:   Altai State Pedagogical University, Kabko V. A. , An S. A.
Published: December 2024

The purpose of this article is to investigate the process of formation of aesthetic taste in preschool children through artistic creativity. The study used a comprehensive approach, including analysis of pedagogical literature, observation of children’s activities in preschool institutions, as well as conducting experiments with different types of artistic creativity (drawing, modeling, musical and theatrical games). The study showed that artistic creativity plays a key role in the formation of aesthetic taste in preschool children. Children who actively participate in artistic activities demonstrate higher levels of emotional responsiveness, sense of harmony and the ability to express their thoughts and feelings through various forms of art. Artistic creativity is an effective means for the development of aesthetic taste in preschool children. Teachers are recommended to use an individual approach, integration of different types of art and organization of joint projects to create conditions conducive to the all-round development of the child and the formation of his/her ability to see and appreciate the beauty in the world around him/her.
«IDEAL-SHAPED» PERSONALITY DEVELOPMENT: REREADING THE CLASSICS
Authors:   Institute for Educational Development of Kuzbass, Zabneva E. I.
Published: December 2024

When the world is immersed in the fundamental problem of the future of existing civilizations and their relationships, where the main contradiction and at the same time challenge to the human community is opposition to globalist standards, it is especially important to think about a well-founded concept of modern domestic education. In the context of establishing goals, principles and basic ideas, the leading issue should be anthropological, proclaiming the idea of a person being formed. When answering the question: “What kind of person needs to be raised?”, the author of the article suggests turning to Russian pedagogical classics.
TRADITIONAL FAMILY VALUES IN THE INTERACTION OF PARTICIPANTS IN EDUCATIONAL RELATIONS
Authors:   MBOU “Secondary school № 126”, Barnaul, Taldykina E. M.
Published: December 2024

This work examines the concepts of traditional family values in the modern world, factors influencing the interaction of all participants in educational relations.
IMPROVING THE METHODOLOGY OF ESSAY WRITING FOR PRIMARY SCHOOL STUDENTS
Authors:   Uzbek-Finnish Pedagogical Institute, Urunova F. Kh.
Published: December 2024

This article discusses various methods of teaching essay writing to primary school students. The importance of introducing a variety of methodological techniques in the conditions of the modern educational process is emphasized. Several of the most popular approaches to teaching essay writing are analyzed, each of which has its own characteristics, advantages and disadvantages.
INDICATORS OF CIVICITY IN THE DYNAMICS OF THE CONTENT OF REGULATORY AND EDUCATIONAL-METHODOLOGICAL SUPPORT OF THE COURSE OF SOCIAL SCIENCES IN SCHOOL
Authors:   Altai State Pedagogical University, Brosalin S. E. , Kulish V. V.
Published: December 2024

The article considers the problem of developing civic consciousness within the content of the social studies course at school. The authors highlight the main indicators of civic consciousness and analyze them in the context of changes in the content of the regulatory and educational-methodological support of the social studies course. In the course of the sociological study, three universal, “cross-cutting” indicators were identified, presented in all regulatory and methodological documents determining the content of the social studies course at the level of secondary general education: “civic responsibility”, “conscientious attitude to work”, “awareness and compliance with laws, their rights and responsibilities”. Conclusions are presented on the need to include a set of other indicators in the content of the regulatory and educational-methodological support of the social studies course to ensure the effectiveness of developing students’ civic consciousness in social studies lessons.
Mittag-Leffler Functions and the Sawi Transform: A New Approach to Fractional Calculus
Authors: Al-Wadi Alaa , Saadeh Rania , Qazza Ahmad , Batiha Iqbal M.
Published: December 2024

This study uses the Sawi transform and Mittag-Leffler function to introduce a novel method of fractional calculus. The basic characteristics of the Sawi transform and its connection to other transforms such as the Laplace transform are explored. We demonstrate the application of the Sawi transform in deriving novel solutions to fractional differential equations and elucidate the importance of the Mittag-Leffler function in these scenarios. We show the efficiency of the presented method by presenting some nonhomogeneous equations and initial value problems. This study proves the efficacy of the Sawi transform by handling some problems in the sense of Caputo fractional calculus.