bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Role of Tumor-Infiltrating Lymphocytes and CD8+ Cytotoxic Lymphocytes in the Survival of Patients with Breast Cancer
Authors: Shojaei Shahram , Aznab Mozaffar , Rahimi Amirmasoud , Ahmadi Seyed Mojtaba , Eslampia Kumars , Golpazir Arash , Iravani Masoud
Published: January 2023

Background: This study aimed to evaluate the significance of tumor lymphocyte infiltration (TIL) and the number of CD8+ T cells in breast cancer and their relationship with the other clinicopathological factors and overall survival (OS) was investigated.
Materials and Methods: The studied samples were breast cancer patients (2005-2017) referring to the medical oncology departments for treatment. Pathologic samples of breast cancer patients were evaluated in terms of TIL and positive immunohistochemical staining for CD8 cytotoxic cells.
Results: 299 patients were entered into the study, 3 male and 296 female. Their mean follow-up period was 61 months. Statistical findings indicated that lymph involvement is more accompanied by low TIL within the tumor (0.011). Correlations were observed between the estrogen, progesterone receptors, P53 state, and TIL; which were significant by P-value<0.049, P-value=0.024, P-value =0.002, respectively. With any Ki67 value, the number of patients with less than 30% TIL was more considerable than the two other groups with lymphocyte cut-off of 30-50% and more than 50%. Comparison of the OS of patients with positive and negative CD8 cytotoxic lymphocytes in 45 patients with lymphocyte infiltration of equal or more than 40% showed that the OS results were in favor of patients with CD8+ cytotoxic lymphocyte (0.022). Out of 299 patients, 17 died.
Conclusion: Our findings showed that in cases of CD8+ cytotoxic lymphocytes in tumors, the OS of the patients will be enhanced which can act as an independent.
The 5-Year Disease-Free Survival of Third Generation Aromatase Inhibitor for Postmenopausal Women with HR-positive HER2-negative Non-Metastatic Breast Cancer
Authors: Etikasari Ria , Murti Andayani Tri , Endarti Dwi , Taroeno-Hariadi Kartika Widayati
Published: January 2023

Background: Several studies showed the superiority of aromatase inhibitor (AI) as first-line therapy for patients with hormone-receptor (HR)-positive breast cancer (BC). For the clinician, studies in the real world are warranted to determine treatment based on the efficacy of each drug. We conducted a comparison of 5-y disease-free survival (DFS) of each AI in terms of survival benefit.
Materials and Methods: We evaluated 450 medical records of postmenopausal women at Dr. Sardjito General Hospital who were diagnosed with HR-positive HER2-negative BC (stage I – III) from January to December 2019 and had undergone surgery, received chemotherapy or radiation therapy, and at least one year of anastrozole, letrozole, or exemestane administration. Kaplan Meier estimation survival curve was used to analyse of survival rate.
Result: Of 79 patients meeting inclusion criteria, there were 21.52% distant metastases documented. Time to disease progression of anastrozole, letrozole and exemestane was 49 months, 58 months, and 53 months, respectively. Letrozole was found better than anastrozole (hazard ratio (HR)=4.342, 95% CI 0.95-19.95; p=0.038). Letrozole versus exemestane (HR=2.757, 95% CI 0.53-14.33; p=0,206) and anastrozole versus exemestane (HR=1.652, 95% CI 0.56-4.84; p=0.351) were found not significantly different. 5-y DFS rate of letrozole was better found (87.5%) than exemestane (73.7%) and anastrozole (61,4%).
Conclusion: 5-year letrozole administration could be proposed as first-line therapy for postmenopausal women with HR-positive HER2-negative BC. A considerable subject and long-term follow-up are needed for validation.
More Than Meets the Eye: Orbital Swelling in an Adolescent with Sickle Cell Disease
Authors: Elizabeth Hicks Rachel , Alsabri Mohammed , Peichev Mario , Kusum Viswanathan
Published: January 2023

Periorbital swelling is a clinical presentation with a broad differential and potentially deleterious consequence. Causes range from benign, including allergic reaction, to vision- and life-threatening, including orbital cellulitis and orbital infarction. The recent climate of SARS-CoV-2 has further complicated this differential, as the virus poses broad clinical presentations with new manifestations reported frequently. Rapid identification of the underlying etiology is crucial, as treatment approaches diverge greatly. Here, we report the case of an African American adolescent male with a history of homozygous sickle cell anemia presenting to an inner city hospital with bilateral periorbital swelling amid the coronavirus pandemic. Differentials including orbital cellulitis, COVID-MIS-C, orbital inflammatory syndrome, Hoagland sign, and orbital infarction secondary to sickle cell crisis are contrasted. We contrast our case with 12 case reports of orbital infarction in the setting of sickle cell crisis within the past 10 years, highlighting how these presentations, along with commonly reported findings of orbital infarction, compare with our patient.
Hypotensive effects of drug combinations in elderly and old patients with controlled arterial hypertension
Authors: Kovalenko F. A. , Kanorskii S. G.
Published: January 2023

Aim. To assess the frequency of arterial hypotension, orthostatic hypotension, low blood pressure (BP) and their clinical manifestations in the group of elderly and senile patients with a controlled course of arterial hypertension (AH), taking combinations of drugs based on an angiotensin-converting enzyme inhibitor (ACE inhibitor).

Materials and methods. The study included 171 male and female residents of Krasnodar Territory with drug-controlled AH (blood pressure - BP less than 140/90 mm Hg in the background of previous antihypertensive therapy containing an ACE inhibitor perindopril), and with diseases of atherosclerotic genesis. All patients were questioned, tested for balance control, assessed for the risk of falls according to the Morse scale, hypotension in orthostasis was determined, measured office BP, carried out daily monitoring of BP with the determination of the time indices of hypotension and low BP.

Results. Most often patients took a combination of ACE inhibitors with calcium channel blockers (CCB) (28.1% of cases), beta-blockers (BB) (27.1%) or diuretics (29.1%). Assessing the risk of falls on the Morse scale, there was a significantly lower level in patients who took the combination of perindopril with CCB compared with those who received perindopril with BB (15 versus 25 points respectively, p=0.039). Patients receiving perindopril and CCB lost balance in the “legs together” position in 19.3% and in the “tandem” or “semi-tandem” position of the feet in 29.8% of cases, that could be compared to the group taking perindopril and a diuretic (22% and 33.9%, respectively) and significantly lower than in the groups with perindopril and BB therapy (34.5% and 50.9%, respectively, p1=0.037, p2=0.043). The time index of low systolic and diastolic BP during therapy with perindopril and CCB was significantly lower than the corresponding indicator in the groups of patients treated with perindopril and BB (22% and 17% versus 27% and 21%, respectively, p1=0,009, p2=0,024), and the time index of low systolic BP for the combination of perindopril and diuretic is lower than for the combination of perindopril and BB (23% versus 27%, respectively, p=0.023).

Conclusion. The data obtained on the frequency of arterial hypotension, orthostatic hypotension and low BP in the group of elderly and senile patients indicate the advisability of further studying the risks of drug hypotension in order to better personalize the treatment of AH.
Blood pressure target achievement in older adults with hypertension and chronic heart failure with preserved ejection fraction: the impact of adipose tissue function
Authors: Malinova L. I. , Tolstov S. N. , Silina T. S. , Denisova T. P. , Lipatova T. E.
Published: January 2023

Objective. To assess the impact of adipose tissue dysfunction for target blood pressure levels achieving in arterial hypertension (AH) and chronic heart failure with preserved left ventricular ejection fraction (HFpEF) in real clinical practice.

Materials and methods. We examined 91 elderly patients (> 75 y.o.) with AH and HFpEF during hospital admission. The mass and mass fraction of adipose tissue, serum levels of adipokines (adiponectin, leptin) and proinflammatory cytokines (TNFa and IL6) were assessed. Steady normotension at discharge was used as a marker of the target blood pressure level achievement possibility.

Results. By the time of the planned discharge, stable normotension was recorded in 24.2% of patients. In senile patients with failure to achieve normotension, isolated systolic AH was most common - 55.1%. Patients with persistent hypertension at the time of the planned discharge were characterized by a low ability of adipose tissue to secrete adiponectin: 0.05 (0.03; 0.12) vs 0.37 (0.12; 0.5) μg/mL/kg (p = 0.037 ). The minimum values of adiponectin (corrected for adipose tissue mass) were in patients with systolic-diastolic AH (0.04 (0.03; 0.06) μg/ml/kg, Jonkhier-Terpstra test, p = 0.033). A regression model for achieving normotension in senile patients with HFpEF was built with a total percentage of correct classifications of 93.8% before bootstrap and 95.8% after: the maximum values of the Wald statistics were achieved with respect to the predictors "adiponectin", "TNF-a" and "heart rate".

Conclusion. The development of adipose tissue dysfunction, accompanied by a decrease in the “rescue hormone” adiponectin synthesis, is associated with the failure to achieve normotension during medication of the inpatient treatment in senile patients with AH and HFpEF.
Kajian Literatur Penilaian Guru terhadap Keterampilan Siswa dalam Membaca Puisi Tahun 2015—2021
Authors: Maharani Amanda , Yusuf Nabila Nufaiza , Mulyati Yeti , Abidin Yunus
Published: January 2023

The teacher's assessment of students' poetry reading skills has differences in research instruments, especially in the assessment aspect. The assessment instrument used in poetry reading skills is adjusted to the elements contained in the poem. This study aims to describe the literature review of the instruments used in poetry reading assessment. This study used a qualitative method with a literature review approach. The research stages were carried out starting from article collection, article reduction, article display, discussion, and conclusion. Sources of research data are in the form of national articles in the last 6 years (2015-2021). The results showed that the aspect that was often assessed was the aspect of intonation with a percentage of 21%, while the aspect that was rarely used was the aspect of articulation, interpretation and stage mastery with a percentage of 1%. There was also an addition to the assessment aspect of poetry reading from year (2015-2021).
ПРОЯВЛЕНИЕ МИКРОЭЛЕМЕНТОЗОВ У ДЕТЕЙ С РАЗЛИЧНЫМ НУТРИТИВНЫМ СТАТУСОМ
Authors:   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Болотова Н.В. , Скальный А.А. ,   ФГАОУ ВО «Российский университет дружбы народов», Филина Н.Ю. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Чередникова К.А. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Курдиян М.С. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Логачева О.А. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Бочкарев И.А. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России, Сухушина Е.Е. ,   ФГБОУ ВО Саратовский государственный медицинский университет им. В.И. Разумовского Минздрава России
Published: January 2023

В современной диетологии и нутрициологии детского возраста особая роль отводится изучению отклонений элементного гомеостаза как одному из этиологических факторов нарушения нутритивного статуса у детей и подростков. Высокий процент распространенности расстройства питания в детской популяции диктует необходимость исследования одного из предрасполагающих факторов нарушения метаболизма – микроэлементного состава. Цель работы – оценка особенностей минералограммы у детей с различным нутритивным статусом. Обследованы 60 детей (мальчики, девочки) в возрасте от 8 до 15 лет: из них в группу 1 вошло 20 детей с избытком массы тела, в группу 2 – 20 детей с дефицитом массы тела, в группу сравнения – 20 детей с нормальной массой тела и незначительными функциональными нарушениями здоровья. В процессе исследования выявлен спектр микроэлементозов у детей с избытком и дефицитом массы тела, полученные данные соотнесены с данными минералограммы здоровых детей того же возраста и пола. По результатам обследования в группе детей с ожирением были получены эссенциальные полидефициты по уровню йода 50% (10), калия 40% (8) и марганца 40% (8). У пациентов с белково-энергетической недостаточностью отмечен дефицит йода 50% (10), калия 40% (8), натрия 40% (8) и марганца 30% (6), а также высокая степень накопления токсических элементов: алюминия, бария и галлия 10% (2). Пациенты группы сравнения имели сходный спектр дефицита эссенциальных микроэлементов, однако степень дефицита была несколько ниже, чем у пациентов с нарушением нутритивного статуса.
“Por la religión y el emperador, la muerte”
Authors: Escrig Rosa Josep
Published: January 2023

El trabajo repara en los mecanismos de politización contrarrevolucionaria durante la independencia de México y el tiempo del Primer Imperio. A través de diversas fuentes documentales y de los testimonios dejados por los contemporáneos se demuestra la importancia que adquirió la movilización popular, pacífica o armada, en ese periodo de transición. Se atiende de manera preferente a los recursos utilizados para agitar y poner en acción a las clases bajas de la sociedad, tomándose en cuenta el papel de los mediadores, especialmente eclesiásticos. La investigación se alinea con las propuestas metodológicas que han resaltado el papel de los fenómenos de signo reaccionario y antiliberal como partícipes del cambio y de la configuración de la política moderna.
I.A. Bunin’s early fiction in periodicals of 1887–1902
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Morozov Sergey N.
Published: January 2023

The paper examines the history of the earliest publications of Ivan Bunin’s fiction in magazines and newspapers of 1887–1902 and delves into the origins of the young writer’s work. Ivan Bunin’s debut as a prose writer took place in 1887 in the illustrated magazine “Rodina”, where the first poems and stories of the young writer appeared. Not all the stories sent to the editorial offices of magazines were accepted for publication, some of them Bunin had to offer several times to different magazines, sometimes they appeared for the first time only in collections of works made by Bunin himself. The paper also presents statistics of texts of early stories by Bunin, some of which were published only once in newspapers or magazines, while others were published two or three times, but also only in periodicals. However, most of the stories were included by Bunin in his collections and collected works. It is noted that from the period in question no autographs of published stories exist, while autographs of those works that the novice writer did not publish have been preserved. The paper examines critical responses to the novice writer’s publications of his early stories in the periodicals. It is noted that Bunin’s early stories were mostly published in popular magazines or in periodicals for children, but during these years the stories of the young writer have already begun to appear in the metropolitan “thick” magazines.
Electro-assisted assembly of conductive polymer and soft hydrogel into core-shell hybrids
Authors: Da Silva Aruã Clayton , Paterson Thomas Edward , Minev Ivan Rusev
Published: January 2023

Soft hydrogels have become an important class of materials for mimicking and interfacing biological soft tissues with potential applications in drug delivery, tissue engineering and bioelectronics. Creative methods for integrating hydrogels with other materials such as organic conductors are highly desired. Here, we describe the single-step electrosynthesis of PEDOT/alginate into core-shell hybrid structures via an electrochemical-chemical-chemical mechanism. Using a pulsed electropolymerisation protocol, we generated PEDOT in either oxidized or reduced form. By-products of this electrochemical step trigger the chemical reactions for the concomitant assembly of alginate hydrogels. Characterization evidences that PEDOT (core) and alginate (shell) compartments form an electrochemically integrated interface. During growth, both can be loaded with useful cargo. We loaded a negatively charged small molecule and investigated passive and electroactive release mechanisms from the two compartments. Our electro-assisted assembly/crosslinking of integrated PEDOT/alginate hybrids contributes a promising approach to the design of functional interfaces for applications in controlled release and soft electronics.
Intercambios de experiencias e ideas en torno a la teoría e historia y los nuevos retos urbano-territoriales en el S.XXI
Authors: Román López Emilia , Pesoa Marcilla Melisa , Sabaté Bel Joaquín
Published: January 2023

ResumenEl presente número de CIUR recoge algunas de las contribuciones presentadas en decimocuarta edición del Seminario Internacional de Investigación en Urbanismo (SIIU), celebrada en la Escuela Técnica Superior de Arquitectura de Madrid, Universidad Politécnica de Madrid, y presentadas durante los días 16 y 17 de junio de 2022.
Dos décadas de programas de regeneración urbana en Barcelona: sistema de indicadores para la evaluación de su impacto = Two decades of urban regeneration programs in Barcelona: System of indicators to assess their impact
Authors: Esteve-Güell Mar
Published: January 2023

Resumen Los programas de regeneración urbana que se han aplicado en un gran número de ciudades europeas a partir de la creación del programa Urban requieren de sistemas de evaluación rigurosos, comprensivos y homologables. Sin embargo, la medida del impacto de estas intervenciones entraña múltiples dificultades. El presente estudio constituye una aportación de carácter metodológico a los procedimientos de medida del impacto de estos programas. Así, propone la creación de un sistema de indicadores y ensaya su aplicación a través de la evaluación del impacto de los últimos dos programas realizados en Barcelona. Dicha evaluación persigue medir el impacto en distintos campos temáticos, a largo plazo y en diversas áreas de intervención con un método de comparación basado en la identificación de un grupo de control. Los resultados muestran la efectividad del sistema de indicadores propuesto y, en particular, la utilidad de la articulación del sistema de indicadores en campos temáticos.Abstract The urban regeneration programs that have been applied in many European cities since the creation of the Urban program require rigorous, comprehensive, and standardized systems of evaluation. However, measuring the impact of these interventions involves multiple difficulties. This study constitutes a methodological contribution to the procedures for measuring the impact of these programs. Thus, it proposes the creation of a system of indicators and tests its application through the evaluation of the impact of the last two urban regeneration programs carried out in the city of Barcelona. This evaluation seeks to measure the impact in different thematic fields, in the long term and in various areas of intervention with a comparison method based on the identification of a control group. The results show the effectiveness of the proposed system of indicators and the usefulness of the articulation of the indicators system in thematic fields.
New Workflow Predicts Drug Targets Against SARS-CoV-2 via Metabolic Changes in Infected Cells
Authors: Leonidou Nantia , Renz Alina , Mostolizadeh Reihaneh , Dräger Andreas
Published: January 2023

COVID-19 is one of the deadliest respiratory diseases, and its emergence caught the pharmaceutical industry off guard. While vaccines have been rapidly developed, treatment options for infected people remain scarce, and COVID-19 poses a substantial global threat. This study presents a novel workflow to predict robust druggable targets against emerging RNA viruses using metabolic networks and information of the viral structure and its genome sequence. For this purpose, we implemented pymCADRE and PREDICATE to create tissue-specific metabolic models, construct viral biomass functions and predict host-based antiviral targets from more than one genome. We observed that pymCADRE reduces the computational time of flux variability analysis for internal optimizations. We applied these tools to create a new metabolic network of primary bronchial epithelial cells infected with SARS-CoV-2 and identified enzymatic reactions with inhibitory effects. The most promising reported targets were from the purine metabolism, while targeting the pyrimidine and carbohydrate metabolisms seemed to be promising approaches to enhance viral inhibition. Finally, we computationally tested the robustness of our targets in all known variants of concern, verifying our targets’ inhibitory effects. Since laboratory tests are time-consuming and involve complex readouts to track processes, our workflow focuses on metabolic fluxes within infected cells and is applicable for rapid hypothesis-driven identification of potentially exploitable antivirals concerning various viruses and host cell types.
Atmospheric CO2 Two Box Model Accurately Tracks 14C and 13C without Requiring the "Revelle Isotopic Exception"
Authors: Taylor Stephen
Published: January 2023

Although total nett CO2 atmospheric flow can be estimated with reasonable accuracy, the contributing gross fluxes between the atmosphere and the earth's surface are poorly understood. This paper presents a method, driven by the objective of simplicity, by which the global outflow and inflow of CO2 between atmosphere and a globally equivalent "mixing reservoir" can be estimated, using the isotopes 14C and 13C as tracers. It has been asserted that the isotopic carbon in CO2 cannot be directly used as a tracer in flow studies because it is not subject to the Revelle factor. Evidence is provided showing that this view is mistaken. The model contains 7 key parameters which are used to create synthetic records of Δ14C and d13C spanning 200 years or more, including during the period of atmospheric weapons testing and its decay known as the "bomb pulse". By optimising the fit between these computed values and the historical records of d13C and Δ14C, all seven key parameters are determined. The effective "mixing reservoir" is thereby determined to have a size around six times that of the atmosphere, with global outflux rising from 39.7 GTC yr-1 in 1750 to 58.9 GTC/yr in 2020, this figure probably not including annually cycled carbon.
A Selective Survey Review of Computational Intelligence Applications in the Primary Subdomains of Civil Engineering Specializations
Authors: Demertzis Konstantinos , Demertzis Stavros , Iliadis Lazaros
Published: January 2023

Advanced state-of-the-art technologies, mainly computational intelligence including Machine/Deep Learning and Fuzzy Computing, through applied research, can provide added value to modern science and, in general, to entrepreneurship and the economy. Artificial intelligence is the field of computer science that attempts to model concepts such as learning, adaptability and perception to synthesize intelligent behavior in solving complex problems, utilizing elements of adaptation to the environment and philosophical reasoning. About the science of civil engineering and, in general, the construction industry, which is one of the most important in economic entrepreneurship, both in terms of the size of the workforce employed and the amount of capital invested, the penetration of artificial intelligence is possible to change industry business models, eliminate costly mistakes, reduce Jobsite injuries and generally make large-scale engineering projects more efficient. The purpose of the paper is to present the recent research on artificial intelligence methods (machine-deep learning, computer vision, natural language processing, fuzzy systems, robotics, etc.) and the corresponding related technologies related to it (extensive data analysis, blockchain, cloud computing, internet of things, augmented reality), in the fields of application of civil engineering science, including structural engineering, geotechnical engineering, hydraulics and water resources management, marine and coastal technology, transport and transportation infrastructure, planning and technical project management, critical infrastructure security and disaster mitigation..
Identifying Patients in Whom the Follow-up Scheme after Robot-assisted Radical Prostatectomy Could be Optimized in the First Year after Surgery: Reducing Healthcare Burden
Authors: Veerman Hans , Van der Graaf Sophia , Meijer Dennie , Hagens Marinus Jan , Tillier Corinne N. , Van Leeuwen Pim J. , Van der Poel Henk G. , Vis André N.
Published: January 2023

Background: The currently advised follow-up scheme of PSA-testing after robot-assisted radical prostatectomy (RARP) is strict and might pose a burden to our healthcare system. We aimed to optimize the 1-year follow-up scheme for patients who undergo RARP. Methods: All patients with histologically-proven prostate cancer (PCa) who underwent RARP between 2018 and August 2022 in the Prostate Cancer Network the Netherlands were retrospectively evaluated. We excluded patients who underwent salvage RARP and patients who had <1 year of PSA follow-up. Postoperative PSA-values were collected. Biochemical persistence (BCP) was defined as PSA-level >0.10 ng/mL at 0-4 months after RARP, whereas biochemical recurrence (BCR) was defined as PSA-level >0.2 ng/mL at any time point after RARP. We aimed to identify a group of patients who had a very low risk of BCR at different time-points after surgery. Results: Of all 1155 patients, BCP was observed in 151 (13%), of whom 79 (6.8%) had PSA ≥0.2 ng/mL. BCR further developed in 51 (4.7%), and 37 (3.4%) patients at 5-8 and 9-12 months after RARP, respectively. In 12 patients, BCR was found at 5-8 months after RARP in absence of BCP. These patients represented 1.2% (12/1004) of the entire group. In other words, 98.8% (992/1004) of patients who had an unmeasurable PSA-level at 0-4 months after RARP also had unmeasurable PSA-level 5-8 months after surgery. Limitations are the retrospective design and incomplete follow-up. Conclusions: Patients with an unmeasurable PSA-level at 3-4 months after RARP may not need to be retested until 12 months of follow-up as almost 100% of patients will not have biochemically recurrent disease at 5-8 months of follow-up. This will reduce PSA-testing substantially at the costs of hardly any missed patients with recurrent disease.
Defining Psychological Factors of Active Transport in Developing Countries
Authors: Seyedhosseini Seyed-Mohammad , Rashidi Mahdi , Naderan Ali
Published: January 2023

Studying Active Transportation (AT) is widespread in America and Europe's research and stud-ies that include Latent variables (LV) are growing to identify exact results of finding what to do to increase the utility of AT. LVs help us to have more accurate research. LVs are defined as psy-chological factors like feeling safe while you ride at night and thus they are not subjective and hard to understand but very important to increase the utility of using AT modes. In this study, most of the previous studies about bicycling have been reviewed. In this research, different var-iables including subjective and LVs are conducted for maximizing the use of bicycle utility and introduced to have better sight for future researchers to deal with modeling AT mode choice. Results represent the importance of having 'will' for using a bicycle, especially in difficult situa-tions and cultural barriers that affect the cycling of women.
High-Resolution Model of Clew Bay – Model Set-up and Validation Results
Authors: Nagy Hazem , Mamoutos Ioannis , Nolan Glenn , Wilkes Robert , Dabrowski Tomasz
Published: January 2023

Clew Bay is an important aquaculture production area in Ireland. In this study, we focused on a high-resolution simulation of the Clew Bay region based on a Regional Ocean Modelling System (ROMS). Freshwater discharges from eight rivers are included in the model and a wetting-drying scheme has been implemented. The Clew Bay model simulation was validated and calibrated with available observations (e.g., Acoustic Doppler Current Profilers (ADCP), vertical salinity and temperature profiles and tide gauge) in the geographic area of the model domain. High correlations were found between the model outputs and observed temperature, salinity and tide gauge water levels along with small Root Mean Square Errors. This indicates that the model was able to reproduce the oceanographic phenomena in the study area. The Taylor diagram analysis showed a high correlation coefficient (R=0.99) between the ADCP bottom temperature in the Inner Bay and the Clew Bay model, along with a small Centered Root Mean Square Error (RMSD =0.5 ◦ C). High correlation coefficients (R > 0.80) were found between the model and the two ADCPs for the zonal current component. There was a resemblance in structure between the model and the observed salinity profiles, indicating that freshwater was correctly implemented in the model. Moreover, the correlation coefficient between the model and the tidal sea surface height (SSH) was 0.99, with an RMSD of 0.09 m. We discovered that wind direction and speed have a significant impact on the bay's water inflow rate. The model outputs can be used to provide scientists, fishermen and decision-makers with hydrodynamic information on ocean conditions in the bay.
Everett’s Interpretation and Convivial Solipsism
Authors: ZWIRN Hervé
Published: January 2023

I show how the quantum paradoxes occurring when we adopt a standard realist framework (or a framework in which the collapse implies a physical change of the state of the system) vanish if we abandon the idea that a measurement is related (directly or indirectly) to a physical change of state. In Convivial Solipsism, similarly to Everett’s interpretation, there is no collapse of the wave function. But contrary to Everett’s interpretation, there is only one world. This allows also to get rid of any non-locality and to provide a solution to the Wigner’s friend problem and its more recent versions.
Prevalence and Associated Factors of Internet Gaming Disorder among Residents in Saudi Arabia: A Cross-Sectional Study
Authors: Alenezi Shuliweeh , Al fiaar Hamzah , Aldossary Muhammad , Alnafisah Ibrahim , Binkheder Samar , Almaghlouth Ibrahim A. , Alkhiri Aqeel
Published: January 2023

Abstract: Objective: Internet gaming disorder (IGD) is an emerging psychiatric disorder that has received attention over the past decade. Few studies have attempted to describe this disorder in the Saudi population. This study aimed to examine the prevalence of IGD and associated factors. A cross-sectional study was conducted using translated Arabic and a validated questionnaire targeting both genders in Saudi Arabia. Methodology: A cross-sectional study using a validated questionnaire (IGD-20) and targeting Arabic-speaking children, youth, and transitional age including both genders. A snowball approach was used to sample our population using an electronic survey. Logistic regression was used to examine factors associated with IGD diagnosis. The study was guided by the STROBE statement. Results: Among 419 individuals who participated in the study, 171 were classified as non-IGD, 167 were at risk for IGD (RIGD), and 72 were IGD. There is no significant association between IGD diagnosis and gender, nationality, residence, and family income. Time playing per week was significantly associated with IGD diagnosis (X2=49.256, p<0.01). There is a significant association between IGD-20 groups and categorical age groups (X2=10.096, p<0.01). Among our sample, the percentages of males (54.2%) and females (45.8%) who met the criteria for IGD were comparable. Conclusion: IGD and RIGD prevalence was significantly high in both age groups. Both males and females were affected similarly.
Sociobehavioral, Biological and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil
Authors: Lucianelli-Junior Dalberto , Pereira Adenilson Leão , Santos Ozélia Sousa , Paes Maria do Carmo Faria , Ikuta Yuji Magalhães , Silveira Rodrigo , Valentin Fernanda Nogueira
Published: January 2023

Aim: This study aimed to evaluate the sociodemographic, behavioral, and biological profile and its relationship with the emergence of chronic non-communicable diseases in riverside populations in the Xingu region, Pará, Brazil. Methods: Characteristics related to health indicators and which risk factors are considered most important were also analyzed. This is a cross-sectional, exploratory, and descriptive study. The sample consisted of riverside people over 18 years of both sexes. The sample size (n.86) was calculated with a confidence level of 95% and a sample error of 5%. To divide the groups, the K-means clustering algorithm was adopted through an unsupervised method and the values were expressed as median. For continuous and categorical data, the Mann-Whitney and Chi-square tests were used, respectively, and the significance level was set at p<5%. To classify the degree of importance of each variable, the multi-layer perceptron algorithm was applied. Results: Based on this information, the sample was divided into two groups: the group with low or no education, with bad habits and worse health conditions, and the group with opposite characteristics. The risk factors considered for cardiovascular diseases and diabetes in the groups were low education (p < 0.001), sedentary lifestyle (p < 0.01), smoking, alcoholism, body mass index (p < 0.05) and the waist-hip ratio, with values above the expected, in both groups. Conclusions: The factors considered important to have a good health condition or not were the educational and social conditions of these communities and a part of the riverside population was considered healthier than the other.
Pelatihan dan Pendampingan Penulisan Karya Ilmiah Berbasis STEAM bagi Guru dan Siswa MTS Negeri 2 Surakarta
Authors: Nurhasanah Farida , Usodo Budi , Chrisnawati Henny Ekana , Kuswardi Yemi , Sutopo Sutopo , Rahayu Eni Puji
Published: January 2023

One of the efforts to realize the vision and mission of the Government Islamic Junior High School 2 Surakarta (MTS N 2 Surakarta) to be one of the best schools at the national level is by participating in MYRES (Madrasah Young Researcher Super Camp), which conducted annually by the Indonesian Ministry of Religion. The school have participated in this event several times, but unfortunately, the result still needs improvement. After conducting a self-evaluation, there found some possible aspects that caused this situation. The lack of knowledge and experience in conducting research and writing academic articles of the teachers who became students’ supervisors indicated the main problem that caused this situation. Based on this situation, the Government Islamic Junior High School 2 Surakarta (MTS N 2 Surakarta), in collaboration with the Contemporary Mathematics Education Research Group of the Mathematics Education Department, Sebelas Maret University, has conducted intensive training for academic writing to be submitted to MYRES competition. This program was conducted for three months, from April to June 2022. This program comprised of some activities, a workshop on academic writing with a keynote from Yogyakarta State University, continued by intensive training conducted online and offline. Ten proposals resulted from this program, ten were submitted to MYRES, and two of the proposal finally can compete until the semifinal stage.
Keterlibatan Orang Tua dalam Mewujudkan Pendidikan Anak Usia Dini Ramah Anak di Gugus Budi Mulia II Sukoharjo
Authors: Pudyaningtyas Adriani Rahma , Rahmawati Anayanti , Hafidah Ruli , Palupi Warananingtyas , Dewi Nurul Kusuma , Sholeha Vera , Syamsuddin Muhammad Munif
Published: January 2023

Child-Friendly Schools (SRA) prioritize children's rights in learning to actualize individuals who need to be educated with good treatment. The SRA concept is intended to create a safe and enjoyable learning atmosphere at all levels of education, including early childhood education. A comfortable learning atmosphere for students positively impacts physical and psychological well-being, which leads to optimal developmental tasks. There are six components in the implementation of child-friendly PAUD, namely 1)policy, 2)curriculum implementation, 3)educators and education staff, 4)infrastructure, 5)child participation, and 6)parent and community participation. The group needs help realizing child-friendly PAUD, one of which is that the activity programs carried out by these PAUD institutions must meet the SRA indicators. The activity program in question is more specifically an effort to involve parents in realizing SRA. Parenting activities that have been carried out so far have yet to be in harmony with the activities carried out by schools, especially in fulfilling children's rights. Therefore it takes school principals' and teachers' knowledge and skills to design parenting activity programs aligned with school activities to realize SRA. This community service aims to carry out training in preparing parenting activity programs. The method for implementing this activity program consists of five stages, namely: 1)analysis of problems in partner institutions; 2)socialization (brainstorming and equalization of perceptions); 3)workshops; 4)assisting the implementation of child-friendly PAUD activity programs; 5)evaluation.
Aprendizaje colaborativo en la Universidad: análisis de una experiencia con una comunidad virtual en Linkedin
Authors: Micaletto-Belda Dr. Juan Pablo , Martín-Herrera Dra. Inmaculada
Published: January 2023

Este trabajo indaga en una experiencia de aprendizaje colaborativo, desarrollada a través de la red social Linkedin con universitarios de los grados en Comunicación y Comunicación Digital. Para conocer la actividad generada en la comunidad, las habilidades adquiridas y la valoración del alumnado sobre esta práctica, se llevó a cabo un doble estudio cualitativo y cuantitativo mediante sendos instrumentos de medida: una ficha de análisis de contenido y una entrevista estructurada. Los resultados demuestran la implicación de los participantes, quienes afirman haber mejorado sus conocimientos en redes sociales, marketing y publicidad; y sus competencias como curador de información en Internet. Además, la actividad les ha resultado inspiradora y consideran viable su aplicación en casi todas las asignaturas de su Grado universitario.
Sedimentology and stratigraphic evolution of fluvial–tidal transition reservoirs: an outcrop analog for the hydrocarbon-bearing Bahariya Formation, Western Desert, Egypt
Authors: Selim Selim Saber
Published: January 2023

The deposits of the tidal–fluvial transition zone are one of the most significant and complicated components of marginal marine systems. Sedimentological studies of these deposits are necessary due to their heterogeneous nature, which is controlled by competing tidal and fluvial parameters. Outcrop studies are required to understand the architecture, sedimentology, and evolution of tidal–fluvial deposits. The Cenomanian upper unit of the Bahariya Formation in the northern part of the Western Desert of Egypt is a tide-dominated fluvio-estuarine deposit sourced from crystalline basement and Early Cretaceous siliciclastic sedimentary rocks that lie to the southeast and south. Based on sedimentary facies analysis and paleocurrent data, the upper Bahariya Formation is composed of six main architectural elements: 1) river-dominated, tide-influenced point bar, 2) tide-dominated, river-influenced point bar, 3) floodplain, 4) crevasse splay, 5) crevasse channel, and 6) mud plug. These elements are stacked in a multistory tidal–fluvial channel complex and associated depositional elements. The reconstructed paleochannels trend from southeast to northwest, and migrated to the east and southeast. The relative contribution of fluvial processes decreased upwards through the stacked stories, with a corresponding increase in the contribution of tidal processes that were associated with transgression. An understanding of the architecture and sedimentology of the tidal–fluvial transition from outcrop successions allows the improved characterization of tidal–fluvial point-bar reservoirs and associated elements.
Karen Barad’s agential realism and Niels Bohr’s conceptualism
Authors:   Institute of Philosophy, Russian Academy of Sciences, Paramonov Andrei A.
Published: January 2023

In recent years, there has been a growing interest in the human and social sciences to­wards contemporary natural science. In this regard, we can talk about a kind of “natural sciences turn” in these fields of knowledge. It is not just a matter of an active use of ter­minological and ideological baggage from the arsenal of natural sciences, but we can even talk about direct borrowing of argumentation. American researcher Karen Barad is one of the leading figures of this movement. Barad connects her theoretical conception of agential realism directly with quantum mechanics in its interpretation proposed by Niels Bohr. The article compares some of the key concepts of the Bohr vision of quantum mechanics, such as phenomenon, agency of observation with the reading acquired by these concepts in Barad’s agential realism. On a comparative analysis of the interpreta­tion of these concepts by Bohr and Barad a number of problematic points of the concept of agential realism are revealed.
Foundations, problems and perspectives of the modern conceptions of semantic correctness
Authors:   Interregional Non-Governmental Organization “Russian Society for History and Philosophy of Sci­ence”, Smirnov Mikhail A.
Published: January 2023

The notion of semantic correctness (meaningfulness, or sensefulness) of propositions is widespread in logico-philosophical and linguistic works, as well as in experimental cog­nitive science. Nevertheless, its content is not clear. Many discussions connected to its use serve as evidence for its obscurity. In this investigation, I articulate and solve some interrelated problems which should be analyzed to make this notion more intelligible. Firstly, I pose a question whether semantic correctness is a normative or a descriptive characteristic. In other words: does it refer to a certain ideal of language usage ascribed to the abstract rational agent but not necessarily observed or even recognized by real agents (the normative option), or to some attitude of real language users towards linguistic ex­pressions (the descriptive option)? I show that the notion of semantic correctness emerged in theoretical contexts as normative due to its role within certain conceptions of scientific rationality. However, one can say that it also contains a descriptive aspect, but it is needed to state distinctively what this aspect is. Particularly, there is a question: can the compatibility of ontological categories in the worldview of a language user (call it onto­logical correctness) be taken as a criterion of semantic correctness for natural languages? I show that this is inadmissible: ontological categorial mistakes should not be seen as se­mantic deviations because in this case it would be impossible to delimit senseless sen­tences from contradictive and simply false sentences in natural languages. Finally, I pro­pose a novel view of the content of the meaningful/senseless dichotomy. It occupies a special place among semantic distinctions being related to structural laws of knowledge incrementation and discourse deployment. From this perspective, I outline an integral ap­proach to the conditions of meaningfulness/senselessness of propositions considering a number of factors. In particular, I analyze the conditions of senselessness for contradic­tions and tautologies.
Moral aspects of compatibilism
Authors:   Heinrich Heine University Düsseldor, Sekatskaya Maria A.
Published: January 2023

Most participants in the current free will debate do not believe that the thesis of physical determinism is true in the actual world. Regardless of this fact, compatibilists keep argu­ing that free will is compatible with physical determinism, and incompatibilists keep challenging this claim. In the first and second section of this paper, I show that the com­patibility of free will with physical determinism is mainly discussed as a means to clarify what the criteria of free will and moral responsibility are. Many naturalistically minded libertarians accept the same criteria of free and morally responsible action as many com­patibilists do, but they introduce an additional criterion of indeterminism. In the last three sections, I question the moral implications of this additional criterion. In the third section, I propose a thought experiment in which agents meeting the incompatibilist criteria of freedom (IC-agents) and agents meeting the compatibilist criteria of freedom (CC-agents) live in the same possible world. If libertarians are right that an agent’s moral status depends on whether that agent meets the additional incompatibilist criterion of indeter­minism, then our treatment of IC- and CC-agents in that world should be sensitive to the moral difference between these two types of agents. However, at least in some cir­cumstances this is not the case, as I demonstrate with the example of two moral dilemmas in sections four and five. I conclude that the assumption about the different moral status of CC- and IC-agents is not supported by our moral intuitions, and thus cannot be as­serted by incompatibilists as a self-evident truth, but requires further justification.
The problem of the crisis of ideals in the political philosophy of Semyon Frank (to the 100th anniversary of the “Philosophical steamer”)
Authors:   Institute of Philosophy, Russian Academy of Sciences, Sharova Veronika L.
Published: January 2023

The subject of the article is the problem of the crisis of ideals generated by the European Enlightenment and the Modern era, as interpreted by Russian thinkers of the first third of the 20th century. Building on the conception of Semyon Frank, the author analyzes the relationship between the socio-political ideals of the Enlightenment in the Russian version and false “idols” that led Russia and Europe to an unprecedented escalation of evil in the early 20th century, is analyzed. Particular attention is paid to the assumption that the ideals of democracy as a true power of the people, as a result of uncritical imple­mentation, lead to revolutionary violence and further reproduction of tyranny. Two ver­sions of democracy are considered: according to Frank, one of them is genuine, based on the idea of disinterested service to the truth, and the second is “false”, oriented to­wards a totalitarian utopia, fundamentally hostile to freedom. The author also analyzes Frank’s views on the phenomenon of the “idol of culture”, which is based on the idea of linear progress. According to Frank, linear progress cannot prevent Russia and Europe from falling into barbarism. Moreover, it even significantly contributed to that break­down. It is concluded that Frank as a Christian philosopher and political thinker became one of the relatively few (along with, for example, Fyodor Stepun and Vladimir Weidle), but all the more significant conductors of the Russian cultural tradition in Europe and the European cultural tradition in Russia: that is, a genuine personification of the phe­nomenon of a “Russian European”.