bluuebunny/crossref_metadata_2025 huggingface dataset:
Die Pflegeversicherung: eine vertragswettbewerbsfreie Zone
Authors: Jacobs Klaus
Published: September 2020

Der Beitrag befasst sich mit der Frage, inwieweit vertragswettbewerbliche Steuerung zur Verbesserung der Pflegeversorgung beitragen kann. Hierzu wird die Konzeption der Solidarischen Wettbewerbsordnung der gesetzlichen Krankenversicherung (GKV) betrachtet und ein Blick auf die Erfahrungen gerichtet, die dort seit der Einführung von freier Kassenwahl und Risikostrukturausgleich mit vertragswettbewerblicher Versorgungssteuerung gemacht wurden, bzw. auf die Gründe, warum es in dieser Hinsicht kaum positive Erfahrungen gibt. Vor diesem Hintergrund fällt die Beurteilung der Zweckmäßigkeit vertragswettbewerblicher Steuerung in der Pflegeversicherung negativ aus. Insbesondere ist im Pflegekontext eine wesentliche Funktionsbedingung der GKV-Wettbewerbskonzeption nicht hinreichend erfüllt: die Fähigkeit der (überwiegend alten, multimorbiden und oftmals zudem kognitiv beeinträchtigten) pflegebedürftigen Versicherten zur individuellen Kassen- bzw. Tarifwahl. Außerdem gibt es bislang kein Konzept zur Ausgestaltung eines pflegekompatiblen Risikostrukturausgleichs. Dieser Befund unterstreicht gleichzeitig die Skepsis gegenüber der Forderung nach einer Integration von Pflege- und Krankenversicherung.
Modular invariant models of leptons at level 7
Authors: Ding Gui-Jun , King Stephen F. , Li Cai-Chang , Zhou Ye-Ling
Published: September 2020

Abstract

We consider for the first time level 7 modular invariant flavour models where the lepton mixing originates from the breaking of modular symmetry and couplings responsible for lepton masses are modular forms. The latter are decomposed into irreducible multiplets of the finite modular group Γ7, which is isomorphic to PSL(2, Z7), the projective special linear group of two dimensional matrices over the finite Galois field of seven elements, containing 168 elements, sometimes written as PSL2(7) or Σ(168). At weight 2, there are 26 linearly independent modular forms, organised into a triplet, a septet and two octets of Γ7. A full list of modular forms up to weight 8 are provided. Assuming the absence of flavons, the simplest modular-invariant models based on Γ7 are constructed, in which neutrinos gain masses via either the Weinberg operator or the type-I seesaw mechanism, and their predictions compared to experiment.
Open string QED meson description of the X17 particle and dark matter
Authors: Wong Cheuk-Yin
Published: September 2020

As a quark and an antiquark cannot be isolated, the intrinsic motion of a composite $$ q\overline{q} $$
q

q
¯

system in its lowest-energy states lies predominantly in 1+1 dimensions, as in an open string with the quark and the antiquark at its two ends. Accordingly, we study the lowest-energy states of an open string $$ q\overline{q} $$
q

q
¯

system in QCD and QED in 1+1 dimensions. We show that π0, η, and η′ can be adequately described as open string $$ q\overline{q} $$
q

q
¯

QCD mesons. By extrapolating into the $$ q\overline{q} $$
q

q
¯

QED sector in which a quark and an antiquark interact with the QED interaction, we find an open string isoscalar I(Jπ) = 0(0−) QED meson state at 17.9±1.5 MeV and an isovector (I(Jπ) = 1(0−), I3 = 0) QED meson state at 36.4±3.8 MeV. The predicted masses of the isoscalar and isovector QED mesons are close to the masses of the hypothetical X17 and E38 particles observed recently, making them good candidates for these particles. The decay products of QED mesons may show up as excess e+e− and γγ pairs in the anomalous soft photon phenomenon associated with hadron productions in high-energy hadron-proton collisions and e+-e− annihilations. Measurements of the invariant masses of excess e+e− and γγ pairs will provide tests for the existence of the open string $$ q\overline{q} $$
q

q
¯

QED mesons. An assembly of gravitating QED mesons are expected to emit electron-positron pairs and/or gamma rays and their decay energies and lifetimes will be modified by their gravitational binding energies. Consequently, a self-gravitating isoscalar QED meson assembly whose mass M and radius R satisfy (M/M⨀)/(R/R⨀) ≳ 2 4.71 × 105 will not produce electron-positron pairs nor gamma rays and may be a good candidate for the primordial dark matter.
Stainless steel and NiTi torque archwires and apical root resorption
Authors: Wichelhaus Andrea , Dulla Marc , Sabbagh Hisham , Baumert Uwe , Stocker Thomas
Published: September 2020

Objective

The amount of apical root resorption when using the torque-segmented archwire (TSA) was investigated as well as the extent and direction of the therapeutically indicated apical movement and the treatment duration.

Materials and methods

The degree of apical root resorption in 18 randomly chosen Class II and Class I patients treated with the TSA, as well as in 18 conventionally treated patients were evaluated using pre- and posttreatment panoramic radiographs. The sagittal and vertical apical movements and inclination changes were determined based on pre- and posttreatment lateral cephalograms. Nonparametric tests were applied to test between treatment groups and steps. The Mann–Whitney U test, Kruskal–Wallis, Pearson correlation and Wilcoxon signed-rank test were applied for statistical analysis (p < 0.05).

Results

The incidence of root resorptions was 89–94.4% in low or moderate level. The relative root–crown ratio (rRCR) was not statistically different between the TSA and control groups except tooth 12. The axis of the incisors in the TSA group was significantly improved. The main direction of movement of the apices of the central incisors was retrusion and extrusion. No interdependence between the amount of resorption and the parameters of treatment duration, extent and direction of apical movement were found.

Conclusion

The results of the study showed that the amount of apical root resorption with the TSA is slight to moderate and can be compared to conventional orthodontic treatment. The TSA is hence a suitable method for applying targeted torques to the incisors.
Linear parameter varying sensorless torque control for singularly perturbed induction motor with torque and flux observers
Authors: Khamari Dalila , Benlaloui Idriss , Ouchen Sabir , Makouf Abdesslem , Chrifi Alaoui Larbi
Published: September 2020

In this paper, a new approach being different from the concept of DTC and IFOC for a robust torque control design for induction motor is addressed. The design is based on the framework of singularly perturbed system theory and linear varying parameter systems. In these systems, the rotor flux is considered to be a time-varying parameter in order to guarantee a robust torque control with LPV flux observer with respect to the speed and resistance variations. In fact, this observer is designed to estimate the rotor flux as well as an MRAS observer is introduced to estimate the mechanical speed and rotor resistance. The main feature of this proposed structure is the enhancement of robustness with flux, speed and rotor resistance variation. This improvement leads to a considerable decrease of the torque ripples and ensures the stability for the entire operating range. The obtained simulations and experimental results are used to validate the effectiveness of the proposed control strategy.
Surface-enhanced Raman scattering (SERS)–based immunosystem for ultrasensitive detection of the 90K biomarker
Authors: Gallo Valentina , Lai Antonia , Pasquo Alessandra , Almaviva Salvatore , Iacobelli Stefano , Persichetti Luca , Capellini Giovanni , Antonini Giovanni
Published: September 2020

The research and the individuation of tumour markers in biological fluids are currently one of the main tools to support diagnosis, prognosis, and monitoring of the therapeutic response in oncology. Although the identification of tumour markers in asymptomatic patients is crucial for early diagnosis, its application is still limited by the relatively low sensitivity and the complexity of existing methods (i.e. ELISA, mass spectrometry). We developed an easy, fast, and ultrasensitive surface-enhanced Raman scattering (SERS)–based system, for the detection and quantitation of the LGALS3BP (90K) biomarker that was used as a model, based on the development of antibody-functionalized nanostructured gold surfaces. The detection system was effective for the ultrasensitive detection and characterization of samples of different biochemical compositions. In conclusion, this work could provide the foundation for the development of a medical diagnostic device with the highest predictive power when compared with the methods currently used in cancer diagnostics.
Diffusion tensor imaging in frontostriatal tracts is associated with executive functioning in very preterm children at 9 years of age
Authors: Kallankari Hanna , Saunavaara Virva , Parkkola Riitta , Haataja Leena , Hallman Mikko , Kaukola Tuula
Published: September 2020

Background

Very preterm birth can disturb brain maturation and subject these high-risk children to neurocognitive difficulties later.

Objective

The aim of the study was to evaluate the impact of prematurity on microstructure of frontostriatal tracts in children with no severe neurologic impairment, and to study whether the diffusion tensor imaging metrics of frontostriatal tracts correlate to executive functioning.

Materials and methods

The prospective cohort study comprised 54 very preterm children (mean gestational age 28.8 weeks) and 20 age- and gender-matched term children. None of the children had severe neurologic impairment. The children underwent diffusion tensor imaging and neuropsychological assessments at a mean age of 9 years. We measured quantitative diffusion tensor imaging metrics of frontostriatal tracts using probabilistic tractography. We also administered five subtests from the Developmental Neuropsychological Assessment, Second Edition, to evaluate executive functioning.

Results

Very preterm children had significantly higher fractional anisotropy and axial diffusivity values (P<0.05, corrected for multiple comparison) in dorsolateral prefrontal caudate and ventrolateral prefrontal caudate tracts as compared to term-born children. We found negative correlations between the diffusion tensor imaging metrics of frontostriatal tracts and inhibition functions (P<0.05, corrected for multiple comparison) in very preterm children.

Conclusion

Prematurity has a long-term effect on frontostriatal white matter microstructure that might contribute to difficulties in executive functioning.
A Nordic survey of the management of palliative care in patients with head and neck cancer
Authors: Boëthius Helena , Saarto Tiina , Laurell Göran , Farnebo Lovisa , Mäkitie Antti A.
Published: September 2020

Background

The five Nordic countries with a population of 27M people form a rather homogenous region in terms of health care. The management of Head and Neck Cancer (HNC) is centralized to the 21 university hospitals in these countries. Our aim was to survey the current status of organization of palliative care for patients with HNC in the Nordic countries as the field is rapidly developing.

Materials and methods

A structured web-based questionnaire was sent to all the Departments of Otorhinolaryngology—Head and Neck Surgery and Oncology managing HNC in the Nordic countries.

Results

All 21 (100%) Nordic university hospitals responded to the survey. A majority (over 90%) of the patients are discussed at diagnosis in a multidisciplinary tumor board (MDT), but the presence of a palliative care specialist is lacking in 95% of these MDT’s. The patients have access to specialized palliative care units (n = 14, 67%), teams (n = 10, 48%), and consultants (n = 4, 19%) in the majority of the hospitals.

Conclusion

The present results show that specialized palliative care services are available at the Nordic university hospitals. A major finding was that the collaboration between head and neck surgeons, oncologists and palliative care specialists is not well structured and the palliative care pathway of patients with HNC is not systematically organized. We suggest that early integrated palliative care needs to be included as an addition to the already existing HNC care pathways in the Nordic countries.
Survey of European neurosurgeons’ management of unruptured intracranial aneurysms: inconsistent practice and organization
Authors: Skodvin Torbjørn Øygard , Kloster Roar , Sorteberg Wilhelm , Isaksen Jørgen Gjernes
Published: September 2020

Background

The discovery of an unruptured intracranial aneurysm creates a dilemma between observation and treatment. Neurosurgeons’ routines for risk assessment and treatment decision-making are unknown. The position of evidence-based medicine in European neurosurgery is considered to be weak, high-grade guidelines do not exist and variations between institutions are probable. We aimed to explore European neurosurgeons’ management routines for newly discovered unruptured intracranial aneurysms.

Methods

In cooperation with the European Association of Neurosurgical Societies (EANS), we conducted an online, cross-sectional survey of 420 European neurosurgeons during Spring/Summer 2016 (1533 non-Norwegians invited through the EANS, and 16 Norwegians invited through heads of departments because of the need for additional information for a separate study). We asked about demographic variables, routines for management and risk assessment of newly discovered unruptured intracranial aneurysms and presented a case. We collected information about gross domestic product (GDP) per capita from the International Monetary Fund.

Results

The response rate to the invite from the EANS was 26%, with respondents from 47 countries. More than half of the respondents (n = 226 [54%]) reported that their department treated less than 25 unruptured aneurysms yearly. Forty percent said their department used aneurysm size cut-off to guide treatment decisions, with a mean size of 6 mm. Presented with a case, respondents from countries with a lower GDP per capita recommended intervention more often than respondents from higher-income countries. Vascular neurosurgeons more commonly recommended observation.

Conclusion

The answers to this self-reported survey indicate that many centers have a treatment volume lower than recommended by international guidelines, and that there are socioeconomic differences in care. Better documentation of treatment and outcome, for example with clinical quality registries, is needed to drive improvements of care.
Does stakeholder engagement affect corruption risk management?
Authors: Monteduro Fabio , Cecchetti Ilenia , Lai Ylenia , Allegrini Veronica
Published: September 2020

Major international organizations such as the Organization for Economic Cooperation and Development (OECD), the United Nations (UN), and the European Union (EU) have stressed the importance of risk management as a useful mechanism to prevent corruption. Anticorruption laws or regulations have been developed around the world, both at regional and national level. These aim to support the design and implementation of proactive management of corruption risks in the public sector. This article aimed to investigate the relationship between stakeholder engagement and the extent of implementation of corruption risk management systems by public organizations. We analysed the anticorruption plans of 343 Italian administrations to explore how different categories of stakeholders (i.e. employees, governing bodies, users/citizens associations) can contribute to the corruption risk management process. We found that the involvement of external and internal stakeholders can positively affect the extent of implementation of corruption risk management systems by public organizations. We explained our results by referring to both traditional organizational theories (institutional theory and the resource-based view) and public governance theories (collaborative and inclusive governance). Institutional pressures, knowledge and values emerged as keys to understanding the results.
The dynamic analysis of load motion during the interaction of wind pressure
Authors: Cekus Dawid , Kwiatoń Paweł , Geisler Tomasz
Published: September 2020

This work presents the analysis of the load motion during the interaction of wind pressure. The load was treated as a rigid body, and the rope system model as a non-deformed. The influence of effective area of wind pressure on load motion was considered. The theoretical model of load motion was presented, which may be an universal approach for transporting machines equipped with a rope-lifting system. To define the orientation of the movable Cartesian coordinate system related to the load, Bryant angles were used. An algorithm and computational program were developed to allow for analysis of dynamic phenomena. The initial problem was solved with the use of the ode45 calculation procedure in the Matlab software on the basis of the Runge–Kutta 4th Order Method. The obtained results were verified with the experimental ones achieved in the wind tunnel and Tracker program. Numerical calculations using commercial software SolidWorks were also presented. In the experiment, the spatial motion of the load was analysed. Experimental tests were carried out for gust of wind and constant temperature and humidity. In addition, the paper presents the application of the proposed method for a load carried by a rotary crane. After taking into account the control functions resulting from the nature of the work of any machine, the formulated model can be a full description of the carried load motion taking into account external forces.
Embedding Values in Artificial Intelligence (AI) Systems
Authors: van de Poel Ibo
Published: September 2020

Organizations such as the EU High-Level Expert Group on AI and the IEEE have recently formulated ethical principles and (moral) values that should be adhered to in the design and deployment of artificial intelligence (AI). These include respect for autonomy, non-maleficence, fairness, transparency, explainability, and accountability. But how can we ensure and verify that an AI system actually respects these values? To help answer this question, I propose an account for determining when an AI system can be said to embody certain values. This account understands embodied values as the result of design activities intended to embed those values in such systems. AI systems are here understood as a special kind of sociotechnical system that, like traditional sociotechnical systems, are composed of technical artifacts, human agents, and institutions but—in addition—contain artificial agents and certain technical norms that regulate interactions between artificial agents and other elements of the system. The specific challenges and opportunities of embedding values in AI systems are discussed, and some lessons for better embedding values in AI systems are drawn.
Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis
Authors: Akintade Damilare D. , Chaudhuri Bhabatosh
Published: September 2020

Eukaryotic elongation factor 1A1 (eEF1A1) is central to translational activity. It is involved in complexes that form signal transduction with protein kinase C, as well as being a signal transducer and activator of transcription 3. eEF1A1 and eEF1A2 are isoforms of the alpha subunit of elongating factor 1 complex. It has been reported that eEF1A1 is expressed in most human tissues but the brain, skeletal muscle and heart. eEF1A1 has been linked to both apoptosis and anti-apoptotic activities. In this study, eEF1A1 was co-expressed with Bax, a proapoptotic protein via heterologous expression of recombinant DNA in yeast cells. Assays were carried out to monitor the fate and state of yeast cells when eEF1A1 was co-expressed with Bax. The yeast strain (bearing an integrated copy of the Bax gene) was transformed with an episomal 2-micron plasmid that encodes HA-tagged eEF1A1 gene. The resultant strain would allow co-expression of Bax and eEF1A1 in yeast cells, Bax being under the control of the GAL1 promoter, while the PGK1 promoter drives eEF1A1 expression. Bcl 2A1, a known anti-apoptotic protein, was also co-expressed with Bax in yeast cells as a positive control, to study the anti-apoptotic characteristic of eEF-1A1. The part eEF1A1 plays in apoptosis has been contentious, amidst the pro and anti-apoptotic properties of eEF1A1, it was shown clearly, in this study that eEF1A1 portrays only anti-apoptotic property in the presence of pro-apoptotic protein, Bax.
Understanding COVID-19 nonlinear multi-scale dynamic spreading in Italy
Authors: Quaranta Giuseppe , Formica Giovanni , Machado J. Tenreiro , Lacarbonara Walter , Masri Sami F.
Published: September 2020

The outbreak of COVID-19 in Italy took place in Lombardia, a densely populated and highly industrialized northern region, and spread across the northern and central part of Italy according to quite different temporal and spatial patterns. In this work, a multi-scale territorial analysis of the pandemic is carried out using various models and data-driven approaches. Specifically, a logistic regression is employed to capture the evolution of the total positive cases in each region and throughout Italy, and an enhanced version of a SIR-type model is tuned to fit the different territorial epidemic dynamics via a differential evolution algorithm. Hierarchical clustering and multidimensional analysis are further exploited to reveal the similarities/dissimilarities of the remarkably different geographical epidemic developments. The combination of parametric identifications and multi-scale data-driven analyses paves the way toward a closer understanding of the nonlinear, spatially nonuniform epidemic spreading in Italy.
A pixel level evaluation of five multitemporal global gridded population datasets: a case study in Sweden, 1990–2015
Authors: Archila Bustos Maria Francisca , Hall Ola , Niedomysl Thomas , Ernstson Ulf
Published: September 2020

Human activity is a major driver of change and has contributed to many of the challenges we face today. Detailed information about human population distribution is fundamental and use of freely available, high-resolution, gridded datasets on global population as a source of such information is increasing. However, there is little research to guide users in dataset choice. This study evaluates five of the most commonly used global gridded population datasets against a high-resolution Swedish population dataset on a pixel level. We show that datasets which employ more complex modeling techniques exhibit lower errors overall but no one dataset performs best under all situations. Furthermore, differences exist in how unpopulated areas are identified and changes in algorithms over time affect accuracy. Our results provide guidance in navigating the differences between the most commonly used gridded population datasets and will help researchers and policy makers identify the most suitable datasets under varying conditions.
Epistemology of testimony and values in science
Authors: Margitay Tihamér
Published: September 2020

The paper has two interconnected objectives. It argues that the intrinsic epistemic value of testimonies (i.e., serving as evidence for what is asserted) can be reduced to their moral and social values, that is, to their competent, conscientious, and honest performance. Consequently, competence, conscientiousness, and honesty are intrinsic epistemic values in science. The second objective is to offer an answer to the questions why and under what conditions a hearer can rationally accept a testimony in science. The values and subsequent norms of testimony are espoused and strictly enforced by the scientific community. The norms of testimony ensure that rule-following scientists testify competently, conscientiously, and honestly. Due to value reduction, such testimonies also manifest their intrinsic epistemic value, that is, they serve as evidence for their content. So, if the norms of testimony are followed, then it is epistemically rational to adopt also the norm of the acceptance of testimonies. When the hearer accepts a testimony (unless he has counterevidence), he simply—and usually blindly—complies with this norm. Yet, he is epistemically rational because the norm he follows is epistemically rational, as well.
Structural and functional responses of Carex aquatilis to increasing sodium concentrations
Authors: Vitt Dale H. , Glaeser Lilyan C. , House Melissa , Kitchen Samantha P.
Published: September 2020

Carex aquatilis is a widespread boreal species that is abundant in open fens and marshes. The species has broad natural tolerances to differing water levels and ion concentrations including occurrences in brackish marshes but not sodic wetlands. Sandhill Wetland, constructed on Syncrude Canada Ltd. mineral surface lease in the Athabasca Oil Sands Region, is a research site that was engineered to support a self-sustaining wetland. The site is currently in its eighth year post wet-up and is partially dominated by C. aquatilis. Increasing Na+ concentrations in the porewaters at Sandhill Wetland are an on-going concern for the performance of the existing plant communities. Here we examine the responses of C. aquatilis to an increasing regime of sodium carried out in a greenhouse experiment. We posed three questions for this experiment: (1) is there a threshold response for performance of C. aquatilis to increasing sodium, (2) if so, does it occur in the range of sodium that is present at current reclamation programs, and (3) is C. aquatilis resistant to high concentrations of sodium? Carex aquatilis survived all treatment concentrations of sodium including the highest treatment of 2354 mg L− 1. In general, both structural and functional attributes of C. aquatilis did not differ between the 17 and 1079 mg L− 1 treatments; however, performances of all attributes were reduced in the 2354 mg L− 1 treatment. Belowground biomass had greater decreases compared to aboveground components, including both biomass and photosynthesis. The aboveground decreases in performance were associated with exclusion of sodium from the aboveground components by the belowground components. Reduction in photosynthesis was strongly correlated with reduced stomatal conductance and lower transpiration. Although C. aquatilis demonstrated a wide tolerance to sodium concentrations, a clear threshold was present between 1079 and 2354 mg L− 1. These decreases in performance in our greenhouse trials were at levels currently present at Sandhill Wetland, and careful assessment of sodium concentrations in the near future needs to be continued.
Effects of salinity on the treatment of synthetic petroleum-industry wastewater in pilot vertical flow constructed wetlands under simulated hot arid climatic conditions
Authors: Wagner Thomas V. , Al-Manji Fatma , Xue Jie , Wetser Koen , de Wilde Vinnie , Parsons John R. , Rijnaarts Huub H. M. , Langenhoff Alette A. M.
Published: September 2020

Petroleum-industry wastewater (PI-WW) is a potential source of water that can be reused in areas suffering from water stress. This water contains various fractions that need to be removed before reuse, such as light hydrocarbons, heavy metals and conditioning chemicals. Constructed wetlands (CWs) can remove these fractions, but the range of PI-WW salinities that can be treated in CWs and the influence of an increasing salinity on the CW removal efficiency for abovementioned fractions is unknown. Therefore, the impact of an increasing salinity on the removal of conditioning chemicals benzotriazole, aromatic hydrocarbon benzoic acid, and heavy metal zinc in lab-scale unplanted and Phragmites australis and Typha latifolia planted vertical-flow CWs was tested in the present study. P. australis was less sensitive than T. latifolia to increasing salinities and survived with a NaCl concentration of 12 g/L. The decay of T. latifolia was accompanied by a decrease in the removal efficiency for benzotriazole and benzoic acid, indicating that living vegetation enhanced the removal of these chemicals. Increased salinities resulted in the leaching of zinc from the planted CWs, probably as a result of active plant defence mechanisms against salt shocks that solubilized zinc. Plant growth also resulted in substantial evapotranspiration, leading to an increased salinity of the CW treated effluent. A too high salinity limits the reuse of the CW treated water. Therefore, CW treatment should be followed by desalination technologies to obtain salinities suitable for reuse. In this technology train, CWs enhance the efficiency of physicochemical desalination technologies by removing organics that induce membrane fouling. Hence, P. australis planted CWs are a suitable option for the treatment of water with a salinity below 12 g/L before further treatment or direct reuse in water scarce areas worldwide, where CWs may also boost the local biodiversity.
Cross-Sectional Prevalence of SARS-CoV-2 Among Skilled Nursing Facility Employees and Residents Across Facilities in Seattle
Authors: Weil Ana A. , Newman Kira L. , Ong Thuan D. , Davidson Giana H. , Logue Jennifer , Brandstetter Elisabeth , Magedson Ariana , McDonald Dylan , McCulloch Denise J. , Neme Santiago , Lewis James , Duchin Jeff S. , Zhong Weizhi , Starita Lea M. , Bedford Trevor , Roxby Alison C. , Chu Helen Y.
Published: September 2020

Background

Skilled nursing facilities (SNFs) are high-risk settings for SARS-CoV-2 transmission. Infection rates among employees are infrequently described.

Objective

To describe SARS-CoV-2 rates among SNF employees and residents during a non-outbreak time period, we measured cross-sectional SARS-CoV-2 prevalence across multiple sites in the Seattle area.

Design

SARS-CoV-2 testing was performed for SNF employees and residents using quantitative real-time reverse transcription polymerase chain reaction. A subset of employees completed a sociodemographic and symptom questionnaire.

Participants

Between March 29 and May 13, 2020, we tested 1583 employees and 1208 residents at 16 SNFs for SARS-CoV-2.

Main Measure

SARS-CoV-2 testing results and symptom report among employees and residents.

Key Results

Eleven of the 16 SNFs had one or more resident or employee test positive. Overall, 46 (2.9%) employees had positive or inconclusive testing for SARS-CoV-2, and among those who completed surveys, most were asymptomatic and involved in direct patient care. The majority of employees tested were female (934, 73%), and most employees were Asian (392, 30%), Black (360, 28%), or white (360, 28%). Among the 1208 residents tested, 110 (9.1%) had positive or inconclusive results. There was no association between the presence of positive residents and positive employees within a SNF (p = 0.62, McNemar’s test).

Conclusions

In the largest study of SNFs to date, SARS-CoV-2 infections were detected among both employees and residents. Employees testing positive were often asymptomatic and involved in direct patient care. Surveillance testing is needed for SNF employees and residents during the pandemic response.
Auditorische Stimulation während des Schlafs
Authors: Schmid S. R. , Nissen C. , Riemann D. , Spiegelhalder K. , Frase L.
Published: September 2020

Die Insomnie, d. h. eine Ein- und/oder Durchschlafstörung, die sich negativ auf die Leistungsfähigkeit und Tagesbefindlichkeit auswirkt, ist eine der häufigsten Erkrankungen in der Allgemeinbevölkerung. Sie wird derzeit meistens pharmakologisch und/oder psychotherapeutisch behandelt, wobei die pharmakologische Behandlung mit Benzodiazepin-Rezeptor-Agonisten zu Abhängigkeit führen kann und die Verfügbarkeit von für die Insomnie-Therapie ausgebildeten Psychotherapeuten momentan nicht in ausreichendem Maße gegeben ist. Durch innovative Behandlungsmethoden könnte hier eine Versorgungslücke effektiv geschlossen werden. Hierzu zählt die auditorische Stimulation, welche vorhandene Sinneskanäle nutzt, um den Schlaf zu beeinflussen. Bisher wurde die auditorische Stimulation vor allem zur Untersuchung von Prozessen der Gedächtniskonsolidierung bei gesunden Probanden angewendet, wobei erfolgreich eine Erhöhung langsamer Oszillationen erreicht wurde, welche vor allem während des Tiefschlafs auftreten. Erste Befunde und sekundäre Outcome-Parameter liefern Hinweise, dass die Potenzierung langsamer Oszillationen durch auditorische Stimulation den Schlaf vertiefen kann, jedoch wurde hierzu bislang keine Studie mit Insomniepatienten durchgeführt. Weitere Forschung bezüglich des Einflusses der Potenzierung langsamer Oszillationen auf die Linderung von Ein- und Durchschlafproblemen bei vorliegender nichtorganischer Insomnie erscheint daher geboten zu sein, um der hohen Beschwerdelast dieser Patientengruppe entgegenzuwirken.
Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender Implications
Authors: Salvio Gianmaria , Gianfelice Claudio , Firmani Francesca , Lunetti Stefano , Balercia Giancarlo , Giacchetti Gilberta
Published: September 2020

Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.
Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower respiratory tract samples of critically ill patients
Authors: Buetti Niccolò , Trimboli Pierpaolo , Mazzuchelli Timothy , Lo Priore Elia , Balmelli Carlo , Trkola Alexandra , Conti Marco , Martinetti Gladys , Elzi Luigia , Ceschi Alessandro , Consonni Vera , Ogna Adam , Forni-Ogna Valentina , Bernasconi Enos
Published: September 2020

Purpose

The length of time a critically ill coronavirus disease 2019 (COVID-19) patient remains infectious and should therefore be isolated remains unknown. This prospective study was undertaken in critically ill patients to evaluate the reliability of single negative real-time polymerase chain reaction (RT-PCR) in lower tracheal aspirates (LTA) in predicting a second negative test and to analyze clinical factors potentially influencing the viral shedding.

Methods

From April 9, 2020 onwards, intubated COVID-19 patients treated in the intensive care unit were systematically evaluated for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by RT-PCR of nasopharyngeal swabs and LTA. The time to negativity was defined as the time between the onset of symptoms and the viral clearance in LTA. In order to identify risk factors for prolonged viral shedding, we used univariate and multivariate Cox proportional hazards models.

Results

Forty-eight intubated SARS-CoV-2 patients were enrolled. Overall, we observed that the association of the first negative RT-PCR with a second negative result was 96.7%. Median viral shedding was 25 (IQR: 21.5–28) days since symptoms’ onset. In the univariate Cox model analysis, type 2 diabetes mellitus was associated with a prolonged viral RNA shedding (hazard ratio [HR]: 0.41, 95% CI: 0.06–3.11, p = 0.04). In the multivariate Cox model analysis, type 2 diabetes was associated with a prolonged viral RNA shedding (HR: 0.31, 95% CI: 0.11–0.89, p = 0.029).

Conclusion

Intubated patients with type 2 diabetes mellitus may have prolonged SARS-CoV-2 shedding. In critically ill COVID-19 patients, one negative LTA should be sufficient to assess and exclude infectivity.
Large-Scale Analysis Reveals Gene Signature for Survival Prediction in Primary Glioblastoma
Authors: Prasad Birbal , Tian Yongji , Li Xinzhong
Published: September 2020

Glioblastoma multiforme (GBM) is the most aggressive and common primary central nervous system tumour. Despite extensive therapy, GBM patients usually have poor prognosis with a median survival of 12–15 months. Novel molecular biomarkers that can improve survival prediction and help with treatment strategies are still urgently required. Here we aimed to robustly identify a gene signature panel for improved survival prediction in primary GBM patients. We identified 2166 differentially expressed genes (DEGs) using meta-analysis of microarray datasets comprising of 955 samples (biggest primary GBM cohort for such studies as per our knowledge) and 3368 DEGs from RNA-seq dataset with 165 samples. Based on the 1443 common DEGs, using univariate Cox and least absolute shrinkage and selection operator (LASSO) with multivariate Cox regression, we identified a survival associated 4-gene signature panel includingIGFBP2,PTPRN,STEAP2andSLC39A10and thereafter established a risk score model that performed well in survival prediction. High-risk group patients had significantly poorer survival as compared with those in the low-risk group (AUC = 0.766 for 1-year prediction). Multivariate analysis demonstrated that predictive value of the 4-gene signature panel was independent of other clinical and pathological features and hence is a potential prognostic biomarker. More importantly, we validated this signature in three independent GBM cohorts to test its generality. In conclusion, our integrated analysis using meta-analysis approach maximizes the use of the available gene expression data and robustly identified a 4-gene panel for predicting survival in primary GBM.
Data-Mining als Werkzeug empirischer Sozialforschung
Authors: Kirchheim Konstantin
Published: September 2020

Der Beitrag zeigt an einem Beispiel, wie Methoden der Informatik genutzt werden können, um die riesigen, teils ungenutzten Datenmengen, die im Internet vorhanden sind und sich aufgrund ihres Volumens einer Untersuchung durch traditionelle Methoden entziehen, ausgewertet werden können. Anhand eines Beispieldatensatzes von ca. 18.000 Rezensionen zu wissenschaftlichen Publikationen aus dem Bereich der Sozialen Arbeit wird gezeigt, wie entsprechende Daten gesammelt, verarbeitet, aggregiert und visualisiert werden können, um sie einer weiterführenden Analyse zugänglich zu machen.
“Psychometric properties and factor structure of the attitudes to fertility and childbearing scale (AFCS) in a sample of polish women”
Authors: Kossakowska Karolina , Söderberg Malin
Published: September 2020

The study aimed to determine the psychometric properties and factor structure of the Attitudes to Fertility and Childbearing Scale (AFCS) in a Polish context. A cross-sectional self-assessment study was conducted with a total group of 748 Polish women in two studies (n = 187 andn = 561, respectively). Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), using SEM were performed. A three-factor structure was extracted by the EFA; although it differed to that identified in the original studies, the CFA found it to be robust. The final Polish version of the AFCS consists of 26 statements, comprising three factors (Fertility and the child as an important value, Child as a barrier,andPersonal awareness and responsibility concerning having a child),which have demonstrated satisfactory internal consistency. Although the original AFCS factor structure was not replicated, our findings demonstrate that the Polish adaptation of the Attitudes to Fertility and Childbearing Scale is a reliable and valid instrument for evaluating attitudes concerning fertility and childbearing in the Polish context.
Effects of pore size, mesostructure and aluminum modification on FDU-12 supported NiMo catalysts for hydrodesulfurization
Authors: Yuan Pei , Lei Xue-Qin , Sun Hong-Ming , Zhang Hong-Wei , Cui Chun-Sheng , Yue Yuan-Yuan , Liu Hai-Yan , Bao Xiao-Jun , Wang Ting-Hai
Published: September 2020

A series of NiMo/FDU-12 catalysts with tunable pore diameters and mesostructures have been controllably synthesized by adjusting the synthetic hydrothermal temperature and applied for the hydrodesulfurization of dibenzothiophene and its derivative. The state-of-the-art electron tomography revealed that the pore sizes of FDU-12 supports were enlarged with the increase in the hydrothermal temperature and the mesostructures were transformed from ordered cage-type pores to locally disordered channels. Meanwhile, the MoS2 morphology altered from small straight bar to semibending arc to spherical shape and finally to larger straight bar with the change of support structures. Among them, FDU-12 hydrothermally treated at 150 °C possessed appropriate pore diameter and connected pore structure and was favorable for the formation of highly active MoS2 with curved morphology; thus, its corresponding catalyst exhibited the best HDS activity. Furthermore, it was indicated that the isomerization pathway could be significantly improved for HDS of 4,6-dimethyldibenzothiophene after the addition of aluminum, which was expected to be applied to the removal of the macromolecular sulfur compounds. Our study sheds lights on the relationship between support effect, active sites morphology and HDS performance, and also provides a guidance for the development of highly active HDS catalysts.
The influence of acetamiprid and deltamethrin on the mortality and behaviour of honeybees (Apis mellifera carnica Pollman) in oilseed rape cultivations
Authors: Dworzańska Daria , Moores Graham , Zamojska Joanna , Strażyński Przemysław , Węgorek Paweł
Published: September 2020

The aim of the research was to determine the influence of acetamiprid and deltamethrin on the mortality and behaviour of honeybees of the same variety, coming from the same source and estimated to be in good condition by a professional beekeeper, but in different years and under different weather conditions. Results of research conducted in field isolators in oilseed rape fields in the years 2012–2018 showed no acetamiprid influence either on the mortality or on the behaviour of honeybees. Deltamethrin activity differed from a lack of influence through causing mortality and a weaker condition of honeybee colonies to the destruction of the colony. This demonstrates the relative safety of acetamiprid to honeybees and the high risk of deltamethrin use. The differences in the bee colonies’ reaction to deltamethrin are probably caused by the high acute toxicity of this active ingredient, genetically dependent, variable metabolic capabilities of particular bee colonies, or coexistence of a variety of different stressors—mainly pathogens.
The plant nutrition impact on the quality and quantity parameters of maize hybrids grain yield based on different statistical methods
Authors: Illés Árpád , Mousavi S. M. Nasir , Bojtor Csaba , Nagy Janos
Published: September 2020

In recent years, producers of agricultural products have increased the use of chemical fertilizers per unit area. The goal of this research was to analyze the interaction of genotype in treatment (NPK fertilizer) on grain yield, protein content, oil content, and the starch content on 13 maize hybrids using analysis by the model of additive and multiplier effects AMMI and to evaluate genotypes, treatments, and their interactions using biplot in Hungary. Treatments include NPK0 (N: 0 kg/ha, P2O5:0 kg/ha, K2O: 0 kg/ha), NPK1 (N: 30 kg/ha, P2O5: 23 kg/ha, K2O: 27 kg/ha), NPK2 (N: 60 kg/ha, P2O5: 46 kg/ha, K2O: 54 kg/ha), NPK3 (N: 90 kg/ha, P2O5: 69 kg/ha, K2O: 81 kg/ha), NPK4 (N: 120 kg/ha, P2O5: 92 kg/ha, K2O: 108 kg/ha), NPK5 (N: 150 kg/ha, P2O5: 115 kg/ha, K2O: 135 kg/ha) in four replications based on complete randomized block design in 2019. The NPK fertilizer effects indicate that the fertilizers are different on yield genotype. AMMI analysis showed that there was a significant difference between genotypes, treatment, and the interaction effect of genotype * treatment at one percent. Besides, the maximum yield had Loupiac and NPK3 on grain yield, Loupiac and NPK2 on oil content, P0023, and NPK3 for starch content, DKC 3/ES4725 (DKC4725) and NPK3 for protein content. Also, GGE biplot analysis indicates that had maximum grain yield in Loupiac, protein content in P9978, oil content in MV Maronetta, and starch content in Sushi.
Thomas Reid on the Ethical Life
Authors: Cuneo Terence
Published: September 2020

This Element presents Thomas Reid's agency-centered ethical theory. This means, one according to which agency intersects with the subject matter of ethics in a sufficiently wide range of important ways that we cannot satisfactorily engage in ethical theorizing without committing ourselves to and, ultimately developing, particular understandings of agency. Reid's agency-centered approach to ethics is introduced, and some ambiguities and puzzling features of his understanding of these components of agency are discussed. The Element explores how Reid might respond to challenges raised by the Aristotelian-Thomistic tradition, on the one hand, and sentimentalism, on the other. The distinctiveness of Reid's approach is also examined here, indicating ways in which his view is not characteristically modern.
Protecting Smallholder Land Rights in Mozambique, 1997–2017: Unfinished Business?
Authors: Walker Michael Madison
Published: September 2020

Mozambique’s land law is notable for its intent to balance the recognition and protection of smallholder land use rights with attracting foreign and domestic investment to rural areas. However, the state’s legitimacy may be undermined through the process of recognition, as state actors and local elites circumvent the law for private gain. Walker focuses on two areas where the law has failed to protect smallholder rights: issues of women’s land rights, and the expansion of protected areas. These issues speak to the problem of recognition, revealing ways the state produces authority, but not necessarily legitimacy, in rural settings.
Wightman and the Perils of Britain’s Withdrawal
Authors: Martinico Giuseppe , Simoncini Marta
Published: September 2020

On 10 December 2018, the Court of Justice (CJEU) delivered the Wightman judgment and recognized the unilateral revocability of the notification ex Art. 50 Treaty on European Union (TEU). This article offers a critical analysis of the decision by insisting above all on the national background of the ruling and the political risks stemming from the decision. The article is structured as follows. Firstly, it analyses the legal questions of the Scottish case, which constituted the ground for the admissibility of the preliminary ruling and showed the perils for the exercise of national sovereign rights embedded in the lack of clarity on revocation options. It thus reconstructs the critical aspects of the preliminary ruling of the CJEU. Subsequently, the article examines the implications of the ruling for the EU legal order. On the one hand, the analysis considers the conception of the EU membership by comparing the approach of the CJEU and that of Advocate General Campos Sánchez Bordona in Wightman.