bluuebunny/crossref_metadata_2025 huggingface dataset:
Intraperitoneal Administration of 17-DMAG as an Effective Treatment against Leishmania braziliensis Infection in BALB/c Mice: A Preclinical Study
Authors: Cruz Kercia P. , Petersen Antonio L. O. A. , Amorim Marina F. , Pinho Alan G. S. F. , Palma Luana C. , Dantas Diana A. S. , Silveira Mariana R. G. , Silva Carine S. A. , Cordeiro Ana Luiza J. , Oliveira Izabella G. , Pita Gabriella B. , Souza Bianca C. A. , Bomfim Gilberto C. , Brodskyn Cláudia I. , Fraga Deborah B. M. , Lima Isadora S. , de_Santana Maria B. R. , Teixeira Helena M. P. , de_Menezes Juliana P. B. , Santos Washington L. C. , Veras Patrícia S. T.
Published: July 2024

Background: Leishmaniasis is a significant global public health issue that is caused by parasites from Leishmania genus. With limited treatment options and rising drug resistance, there is a pressing need for new therapeutic approaches. Molecular chaperones, particularly Hsp90, play a crucial role in parasite biology and are emerging as promising targets for drug development. Objective: This study evaluates the efficacy of 17-DMAG in treating BALB/c mice from cutaneous leishmaniasis through in vitro and in vivo approaches. Materials and Methods: We assessed 17-DMAG’s cytotoxic effect on bone marrow-derived macrophages (BMMΦ) and its effects against L. braziliensis promastigotes and intracellular amastigotes. Additionally, we tested the compound’s efficacy in BALB/c mice infected with L. braziliensis via intraperitoneal administration to evaluate the reduction in lesion size and the decrease in parasite load in the ears and lymph nodes of infected animals. Results: 17-DMAG showed selective toxicity [selective index = 432) towards Leishmania amastigotes, causing minimal damage to host cells. The treatment significantly reduced lesion sizes in mice and resulted in parasite clearance from ears and lymph nodes. It also diminished inflammatory responses and reduced the release of pro-inflammatory cytokines (IL-6, IFN-γ, TNF) and the regulatory cytokine IL-10, underscoring its dual leishmanicidal and anti-inflammatory properties. Conclusions: Our findings confirm the potential of 17-DMAG as a viable treatment for cutaneous leishmaniasis and support further research into its mechanisms and potential applications against other infectious diseases.
Off-Label Use of Bevacizumab in Patients Diagnosed with Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
Authors: Estarreja João , Mendes Priscila , Silva Carina , Camacho Pedro , Mateus Vanessa
Published: July 2024

Background: Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people. Current pharmacological treatment in vascular AMD includes anti-VEGF agents, such as ranibizumab and aflibercept. Additionally, the off-label use of bevacizumab has been shown to be effective and has a lower cost, making it an interesting pharmacological approach; however, there is no consensus about its use. Therefore, this systematic review and meta-analysis aims to evaluate the efficacy, safety, and efficiency of bevacizumab in AMD patients. Methods: This review only focused on randomized controlled clinical trials published in 2010 in the MEDLINE database that compared the effect of bevacizumab with ranibizumab. The risk of bias in each included study was assessed using the CASP Randomised Clinical Trials checklist. Results: Twelve studies were included for qualitative synthesis, and nine of them were considered for meta-analysis. Bevacizumab-treated patients showed a significantly reduced neovascularization in a longer spectrum of time; however, they had a higher incidence of endophthalmitis than those treated with ranibizumab. Regarding efficiency, the mean number of administrations was reduced in the treatment with bevacizumab in comparison to ranibizumab. Conclusions: Clinical evidence demonstrates that bevacizumab has efficacy and safety profiles comparable with ranibizumab; however, it is relatively more efficient.
Rigid Macrocycle Metal Complexes as CXCR4 Chemokine Receptor Antagonists: Influence of Ring Size
Authors: Renard Isaline , D’huys Thomas , Burke Benjamin P. , Ajoleza Trisha , Cain Amy N. , Funwie Neil L. , Khan Abid , Maples Danny L. , Maples Randall D. , Matz Dallas L. , McRobbie Graeme , Ullom Robert , Prior Timothy J. , Linder Douglas P. , Van Loy Tom , Hubin Timothy J. , Schols Dominique , Archibald Stephen J.
Published: July 2024

Understanding the role of chemokine receptors in health and disease has been of increasing interest in recent years. Chemokine receptor CXCR4 has been extensively studied because of its defined role in immune cell trafficking, HIV infection, inflammatory diseases, and cancer progression. We have developed high affinity rigidified CXCR4 antagonists that incorporate metal ions to optimize the binding interactions with the aspartate side chains at the extracellular surface of the CXCR4 chemokine receptor and increase the residence time. Cross- and side-bridged tetraazamacrocylic complexes offer significant advantages over the non-bridged molecular structures in terms of receptor affinity, potential for radiolabelling, and use in therapeutic applications. Our investigation has been extended to the influence of the ring size on bridged tetraazamacrocyclic compounds with the addition of two novel chelators (bis-cross-bridged homocyclen and bis-cross-bridged cyclen) to compare to the bis-bridged cyclam, along with novel metal complexes formed with copper(II) or zinc(II). The in vitro biological assays showed that all of the zinc(II) complexes are high affinity antagonists with a marked increase in CXCR4 selectivity for the bis-cross-bridged cyclen complex, whereas the properties of the copper(II) complexes are highly dependent on metal ion geometry. X-ray crystal structural data and DFT computational studies allow for the rationalisation of the relative affinities and the aspartate residue interactions on the protein surface. Changing the ring size from 14-membered can increase the selectivity for the CXCR4 receptor whilst retaining potent inhibitory activity, improving the key pharmacological characteristics.
Philosophy of ‘Truth Ethics’: Love/Friendship through Kurosawa Films and Badiou’s Philosophy
Authors: Öztürk Serdar , Ahad Waseem
Published: July 2024

Alain Badiou in his philosophy on ethics underscores four fields of truth procedures—love, politics, art, and science—that seek to break with the existing order or conventional flow of things. These four fields indicate both collective (politics, art, and science) as well as individual (love) instances of the subject’s relationships and actions. The individual realm of ‘love’, which is the central focus of this study, however, as a generic, complex category does not clearly explicate the significance of the associated concept, friendship. Akira Kurosawa’s filmography is illustrative as it opens up a possibility for disentangling the concept of friendship from love along with making significant contributions to the ethics of truth, particularly with respect to the “friendship event”. His films vividly capture some of the essential themes of Badiou’s philosophy of truth ethics, including “break”/“encounter”, referred to as ‘event’, “keep going”/“perseverance”, and “fidelity”. Even if the philosophers Badiou and Kurosawa do not make direct references to each other’s works, this research reveals significant parallels between cinephilosophy created through “cine-images” and the written philosophy. By analyzing Kurosawa’s films in the light of Badiou’s philosophy of truth ethics, and vice versa, this study embarks on exploring the complementarities between the works of the two. The study showcases how love and friendship as truth procedures are formed in particular contexts in Kurosawa’s filmography, and how they intersect with other truth events, particularly politics. Most importantly, this study does not view Badiou’s “truth events” such as love, friendship, and politics as mutually exclusive categories; rather, they are seen as complementary in practice.
Tissue Culture Response and In Vitro Plant Regeneration of Malus ‘Baiyun’ (a New Cultivar of Ornamental Crabapple)
Authors: Ma Jingze , Fan Junjun , Zhang Wangxiang , Zhou Ruomiao , Shen Yiting , Peng Qin , Li Huimin , Lei Cong
Published: July 2024

Malus ‘Baiyun’ (registration no. 20210210), a new crabapple cultivar, was registered in 2021 by the Nanjing Forestry Unversity. However, the difficult rooting has greatly limited the production of high-quality M. ‘Baiyun’ in industrialization development. There is thus a pressing need to develop an organogenesis protocol for the in vitro propagation of M. ‘Baiyun’ to alleviate a shortage of high-quality M. ‘Baiyun’ seedlings. The results showed that choosing the apical bud in mid-March was an excellent explant material. To promote proliferation, the highest proliferation (6.27) of apical shoots was cultured on Murashige and Skoog (MS) medium supplemented with 0.5 mg·L−1 6-benzylaminopurine(6-BA) + 0.05 mg·L−1 indole-3-butyric acid (IBA). Subsequently, a 100% rooting rate, average number of roots per shoot of 6.2 and maximum length of roots of 4.96 cm were obtained on half-strength Murashige and Skoog (1/2 MS) medium with the application of 0.5 mg·L−1 naphthaleneacetic acid (NAA) or 0.6 mg·L−1 NAA + 0.7 mg·L−1 IBA. Additionally, thick and lateral roots were obtained with 0.6 mg·L−1 NAA + 0.7 mg·L−1 IBA. Our study is the first to establish an effective organogenesis protocol for new crabapple cultivars using stem segments.
Abscisic Acid Regulates the Occurrence and Recovery of the Striped Leaf Phenotype in Response to Lacking Light at the Base of Sheath in Rice by Modulating Carbohydrate Metabolism
Authors: Chen Jiasheng , Yang Shaowen , Fu Ming , He Ying , Zeng Hanlai
Published: July 2024

Rice B03S mutants with intermittent leaf discoloration were developed from the photoperiod- and thermosensitive genic male sterile (PTGMS) rice line Efeng 1S. After these plants were deeply transplanted, the new leaves manifested typical stripe patterns. In this study, deep and shallow transplantation of B03S was carried out, and aluminum shading was performed directly on the leaf sheath. It was determined that the reason for the appearance of the striped leaf trait was that the base of leaf sheath lacked light, at which time the sheath transformed from the source organ to the sink organ in rice. To elucidate the related metabolic changes in glycometabolism and abscisic acid (ABA) biosynthesis and transcriptional regulation in the leaf sheath, ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) combined with transcriptome and real-time quantitative PCR (qPCR) validation were used for analysis after deep and shallow transplantation. The result indicates that the leaf sheath may need to compete with the new leaves for sucrose produced by the photosynthesis of old leaves in response to lacking light at the base of sheath. Moreover, the ABA content increases in the leaf sheath when the gene expression of ABA2 and AAO1 is upregulated at the same time, enhancing the plant’s resistance to the adverse condition of shading at the leaf sheath. Furthermore, exogenous spraying of B03S with ABA solution was carried out to help recovery under shading stress. The result indicates that the synthesis of endogenous ABA in the leaf sheath is reduced by spraying ABA. At the same time, ABA regulates sucrose metabolism by inhibiting the expression of the SUS gene. This allows for more sucrose synthesized by the old leaves to be transported to the new leaves, resulting an obvious recovery effect of the strip leaf character due to the re-balance of sugar supply and demand in B03S. These findings improve the understanding of the physiological function and metabolic mechanism of the rice leaf sheath, provide a theoretical basis for uneven leaf coloration in nature, and provide theoretical guidance for rice production via seedling transplantation or direct seeding.
Biogeography and Conservation in the Arabian Peninsula: A Present Perspective
Authors: Ghazanfar Shahina A.
Published: July 2024

The Arabian Peninsula, with its rugged mountains, wadis, alluvial plains, sand dune deserts, and diverse coastlines, spans over 3 million km2. The Peninsula is situated at the crossroads of Africa and Asia and is a meeting point for diverse biogeographic realms, including the Palearctic, Afrotropical, and Indomalayan regions. This convergence of biogeographic zones has resulted in a remarkably diverse flora and fauna, which is adapted to the harsh and varied climates found throughout the Peninsula. Each of the countries of the Arabian Peninsula are biologically diverse and unique in their own right, but Yemen, Saudi Arabia, and Oman are the most diverse in terms of their landforms and biological diversity. The mountainous regions support a cooler and more moderate climate compared to the surrounding lowlands, thus forming unique ecosystems that function as refugia for plant and animal species, and have a high endemism of plant species. The desert ecosystems support a variety of lifeforms that are specially adapted to an extreme arid climate. Due to its long history of human habitation and subsistence agriculture, particularly in the mountainous areas, the Arabian Peninsula possesses unique crop varieties adapted to extreme arid climates, making them important genetic resources for the future in the face of climate change. The Arabian Peninsula, though rich and diverse in its biological diversity, has been greatly affected by human activities, especially in the last 50 years, including urbanization, habitat destruction, overgrazing, and climate change, which pose significant threats to the biodiversity of the region. This review presents the biogeography and background of conservation efforts made in the countries in the Arabian Peninsula and gives the progress made in botanical research and conservation practices throughout the Peninsula.
Karrikinolide1 (KAR1), a Bioactive Compound from Smoke, Improves the Germination of Morphologically Dormant Apium graveolens L. Seeds by Reducing Indole-3-Acetic Acid (IAA) Levels
Authors: Gupta Shubhpriya , Hrdlička Jakub , Kulkarni Manoj , Doležalova Ivana , Pěnčík Aleš , Van Staden Johannes , Novák Ondřej , Doležal Karel
Published: July 2024

Smoke-water (SW) and Karrikinolide1 (KAR1) release dormancy and improve seed germination in many plant species. Therefore, we tested SW (1:2500 v/v) and KAR1 (10−7 M) to break the morphological dormancy of celery cultivar (Apium graveolens L.). In the first trial, seeds were subjected to a 21-day incubation period at 20 °C with SW and KAR1 applied as single treatments. KAR1 showed significantly improved germination (30.7%) as compared to SW (17.2%) and a water control (14.7%). In seed soaking experiments, SW, KAR1, and gibberellic acid (GA3) treatments showed higher germination percentages than the water control after 3 and 6 h of soaking. However, prolonged soaking (12 h) reduced germination percentages for all treatments, indicating a detrimental effect. Analysis of KAR1 content dynamics in 7-day- and 21-day-old celery seeds indicated its prolonged effects on germination and dormancy alleviation. Phytohormones, including auxins in 7-day-old and cytokinins in 7-day- and 21-day-old celery seedlings, along with their precursors and metabolites, were analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) after treatment with KAR1 and SW. The analysis of auxin levels in 7-day-old seeds revealed a negative correlation between seed germination and auxin (indole-3-acetic acid, IAA) content. Notably, it was found that KAR1-treated seeds significantly reduced IAA levels in all treatments. SW and KAR1 did not significantly affect cytokinin levels during celery germination except for N6-Isopentenyladenine. Hence, further research is needed to understand their precise role in celery seed germination. This work will improve our understanding of the role of bioactive compounds from plant-derived smoke and how they regulate hormonal responses and improve germination efficiency in celery.
Recent Progress in Circularly Polarized Luminescent Materials Based on Cyclodextrins
Authors: Zhou Chengkai , Chang Weixing , Liu Lingyan , Li Jing
Published: July 2024

Circularly polarized luminescence (CPL) materials have been widely used in the fields of bioimaging, optoelectronic devices, and optical communications. The supramolecular interaction, involving harnessing non-covalent interactions between host and guest molecules to control their arrangements and assemblies, represents an advanced approach for facilitating the development of CPL materials and finely constructing and tuning the desired CPL properties. Cyclodextrins (CDs) are cyclic natural polysaccharides, which have also been ubiquitous in various fields such as molecular recognition, drug encapsulation, and catalyst separation. By adjusting the interactions between CDs and guest molecules precisely, composite materials with CPL properties can be facilely generated. This review aims to outline the design strategies and performance of CD-based CPL materials comprehensively and provides a detailed illustration of the interactions between host and guest molecules.
Enhancing the Biodegradability, Water Solubility, and Thermal Properties of Polyvinyl Alcohol through Natural Polymer Blending: An Approach toward Sustainable Polymer Applications
Authors: Elgharbawy Abdallah S. , El Demerdash Abdel-Ghaffar M. , Sadik Wagih A. , Kasaby Mosaad A. , Lotfy Ahmed H. , Osman Ahmed I.
Published: July 2024

The escalating environmental crisis posed by single-use plastics underscores the urgent need for sustainable alternatives. This study provides an approach to introduce biodegradable polymer blends by blending synthetic polyvinyl alcohol (PVA) with natural polymers—corn starch (CS) and hydroxypropyl methylcellulose (HPMC)—to address this challenge. Through a comprehensive analysis, including of the structure, mechanical strength, water solubility, biodegradability, and thermal properties, we investigated the enhanced performance of PVA-CS and PVA-HPMC blends over conventional polymers. Scanning electron microscopy (SEM) findings of pure PVA and its blends were studied, and we found a complete homogeneity between the PVA and both types of natural polymers in the case of a high concentration of PVA, whereas at lower concentration of PVA, some granules of CS and HMPC appear in the SEM. Blending corn starch (CS) with PVA significantly boosts its biodegradability in soil environments, since adding starch of 50 w/w duplicates the rate of PVA biodegradation. Incorporating hydroxypropyl methylcellulose (HPMC) with PVA not only improves water solubility but also enhances biodegradation rates, as the addition of HPMC increases the biodegradation of pure PVA from 10 to 100% and raises the water solubility from 80 to 100%, highlighting the significant acceleration of the biodegradation process and water solubility caused by HPMC addition, making these blends suitable for a wide range of applications, from packaging and agricultural films to biomedical engineering. The thermal properties of pure PVA and its blends with natural were studied using diffraction scanning calorimetry (DSC). It is found that the glass transition temperature (Tg) increases after adding natural polymers to PVA, referring to an improvement in the molecular weight and intermolecular interactions between blend molecules. Moreover, the amorphous structure of natural polymers makes the melting temperature ™ lessen after adding natural polymer, so the blends require lower temperature to remelt and be recycled again. For the mechanical properties, both types of natural polymer decrease the tensile strength and elongation at break, which overall weakens the mechanical properties of PVA. Our findings offer a promising pathway for the development of environmentally friendly polymers that do not compromise on performance, marking a significant step forward in polymer science’s contribution to sustainability. This work presents detailed experimental and theoretical insights into novel polymerization methods and the utilization of biological strategies for advanced material design.
A Novel, Dual-Initiator, Continuous-Suspension Grafting Strategy for the Preparation of PP-g-AA-MAH Fibers to Remove of Indigo from Wastewater
Authors: Xie Sijia , Fang Ziyang , Lian Zhouyang , Luo Zhengwei , Zhang Xueying , Ma Shengxiu
Published: July 2024

The indigo dye found in wastewater from printing and dyeing processes is potentially carcinogenic, teratogenic, and mutagenic, making it a serious threat to the health of animals, plants, and humans. Motivated by the growing need to remove indigo from wastewater, this study prepared novel fiber absorbents using melt-blow polypropylene (PP) melt as a matrix, as well as acrylic acid (AA) and maleic anhydride (MAH) as functional monomers. The modification conditions were studied to optimize the double-initiation, continuous-suspension grafting process, and then functional fibers were prepared by melt-blown spinning the modified PP. The results showed that the optimum modification conditions were as follows: a 3.5 wt% interfacial agent, 8 mg/L of dispersant, 80% monomer content, a 0.8 mass ratio of AA to MAH, a 1000 r/min stir speed, 3.5 wt% initiator DBPH grafting at 130 °C for 3 h, and 1 wt% initiator BPO grafting at 90 °C for 2 h. The highest grafting rate of the PP-g-AA-MAH was 31.2%, and the infrared spectrum and nuclear magnetic resonance spectroscopic analysis showed that AA and MAH were successfully grafted onto PP fiber. This modification strategy also made the fibers more hydrophilic. The adsorption capacity of the PP-g-AA-MAH fibers was highly dependent on pH, and the highest indigo adsorption capacity was 110.43 mg/g at pH 7. The fiber adsorption capacity for indigo increased rapidly before plateauing with increasing time or indigo concentration, and the experimental data were well described in a pseudo-second-order kinetic model and a Langmuir isothermal adsorption model. Most impressively, the modified fiber adsorption capacity for indigo remained as high as 91.22 mg/g after eight regeneration and reuse cycles. In summary, the PP-g-AA-MAH fibers, with excellent adsorption-desorption characteristics, could be readily regenerated and reused, and they are a promising material for the removal of indigo from wastewater.
Wearable Smart Silicone Belt for Human Motion Monitoring and Power Generation
Authors: Zhou Lijun , Liu Xue , Zhong Wei , Pan Qinying , Sun Chao , Gu Zhanyong , Fang Jiwen , Li Chong , Wang Jia , Dong Xiaohong , Shao Jiang
Published: July 2024

Human physical activity monitoring plays a crucial role in promoting personalized health management. In this work, inspired by an ancient Chinese belt, a belt-type wearable sensor (BWS) based on a triboelectric nanogenerator (TENG) is presented to monitor daily movements and collect the body motion mechanical energy. The developed BWS consists of a soft silicone sheet and systematically connected sensing units made from triboelectric polymer materials including polytetrafluoroethylene (PTFE) and polyamide (PA). A parameter study of the sensing units is firstly conducted to optimize the structure of BWS. The experimental studies indicate that the parameter-optimized BWS unit achieves a maximum output voltage of 47 V and a maximum current of 0.17 μA. A BWS with five sensing units is manufactured to record body movements, and it is able to distinguish different physical activities including stillness, walking, running, jumping, normal breathing, cessation of breathing, and deep breathing. In addition, the developed BWS successfully powers electronic devices including a smartphone, digital watch, and LED lights. We hope this work provides a new strategy for the development of wearable self-powered intelligent devices.
Novel Thermosensitive and Mucoadhesive Nasal Hydrogel Containing 5-MeO-DMT Optimized Using Box-Behnken Experimental Design
Authors: Miranda Pablo , Castro Analía , Díaz Paola , Minini Lucía , Ferraro Florencia , Paulsen Erika , Faccio Ricardo , Pardo Helena
Published: July 2024

We present the development and characterization of a nasal drug delivery system comprised of a thermosensitive mucoadhesive hydrogel based on a mixture of the polymers Poloxamer 407, Poloxamer 188 and Hydroxypropyl-methylcellulose, and the psychedelic drug 5-methoxy-N,-N-dimethyltryptamine. The development relied on a 3 × 3 Box-Behnken experimental design, focusing on optimizing gelification temperature, viscosity and mucoadhesion. The primary objective of this work was to tailor the formulation for efficient nasal drug delivery. This would increase contact time between the hydrogel and the mucosa while preserving normal ciliary functioning. Following optimization, the final formulation underwent characterization through an examination of the in vitro drug release profile via dialysis under sink conditions. Additionally, homogeneity of its composition was assessed using Raman Confocal Spectroscopy. The results demonstrate complete mixing of drug and polymers within the hydrogel matrix. Furthermore, the formulation exhibits sustained release profile, with 73.76% of the drug being delivered after 5 h in vitro. This will enable future studies to assess the possibility of using this formulation to treat certain mental disorders. We have successfully developed a promising thermosensitive and mucoadhesive hydrogel with a gelling temperature of around 32 °C, a viscosity close to 100 mPas and a mucoadhesion of nearly 4.20 N·m.
Crosslinking and Swelling Properties of pH-Responsive Poly(Ethylene Glycol)/Poly(Acrylic Acid) Interpenetrating Polymer Network Hydrogels
Authors: Hwang Uijung , Moon HoYeon , Park Junyoung , Jung Hyun Wook
Published: July 2024

This study investigates the crosslinking dynamics and swelling properties of pH-responsive poly(ethylene glycol) (PEG)/poly(acrylic acid) (PAA) interpenetrating polymer network (IPN) hydrogels. These hydrogels feature denser crosslinked networks compared to PEG single network (SN) hydrogels. Fabrication involved a two-step UV curing process: First, forming PEG-SN hydrogels using poly(ethylene glycol) diacrylate (PEGDA) through UV-induced free radical polymerization and crosslinking reactions, then immersing them in PAA solutions with two different molar ratios of acrylic acid (AA) monomer and poly(ethylene glycol) dimethacrylate (PEGDMA) crosslinker. A subsequent UV curing step created PAA networks within the pre-fabricated PEG hydrogels. The incorporation of AA with ionizable functional groups imparted pH sensitivity to the hydrogels, allowing the swelling ratio to respond to environmental pH changes. Rheological analysis showed that PEG/PAA IPN hydrogels had a higher storage modulus (G′) than PEG-SN hydrogels, with PEG/PAA-IPN5 exhibiting the highest modulus. Thermal analysis via thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) indicated increased thermal stability for PEG/PAA-IPN5 compared to PEG/PAA-IPN1, due to higher crosslinking density from increased PEGDMA content. Consistent with the storage modulus trend, PEG/PAA-IPN hydrogels demonstrated superior mechanical properties compared to PEG-SN hydrogels. The tighter network structure led to reduced water uptake and a higher gel modulus in swollen IPN hydrogels, attributed to the increased density of active network strands. Below the pKa (4.3) of acrylic acid, hydrogen bonds between PEG and PAA chains caused the IPN hydrogels to contract. Above the pKa, ionization of PAA chains induced electrostatic repulsion and osmotic forces, increasing water absorption. Adjusting the crosslinking density of the PAA network enabled fine-tuning of the IPN hydrogels’ properties, allowing comprehensive comparison of single network and IPN characteristics.
Potential of Pullulan-Based Polymeric Nanoparticles for Improving Drug Physicochemical Properties and Effectiveness
Authors: Thomas Nurain , Puluhulawa Lisa Efriani , Cindana Mo’o Faradila Ratu , Rusdin Agus , Gazzali Amirah Mohd , Budiman Arif
Published: July 2024

Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has gained prominence in nanomedicine. Its application in nanoparticle drug delivery systems showcases its potential for precision medicine. Aim of Study: This scientific review aims to comprehensively discuss and summarize recent advancements in pullulan-based polymeric nanoparticles, focusing on their formulation, characterization, evaluation, and efficacy. Methodology: A search on Scopus, PubMed, and Google Scholar, using “Pullulan and Nanoparticle” as keywords, identified relevant articles in recent years. Results: The literature search highlighted a diverse range of studies on the pullulan-based polymeric nanoparticles, including the success of high-selectivity hybrid pullulan-based nanoparticles for efficient boron delivery in colon cancer as the active targeting nanoparticle, the specific and high-efficiency release profile of the development of hyalgan-coated pullulan-based nanoparticles, and the design of multifunctional microneedle patches that incorporated pullulan–collagen-based nanoparticle-loaded antimicrobials to accelerate wound healing. These studies collectively underscore the versatility and transformative potential of pullulan-based polymeric nanoparticles in addressing biomedical challenges. Conclusion: Pullulan-based polymeric nanoparticles are promising candidates for innovative drug delivery systems, with the potential to overcome the limitations associated with traditional delivery methods.
The Effect of Carbon Nanofibers on the Mechanical Performance of Epoxy-Based Composites: A Review
Authors: Santos Paulo , Silva Abílio P. , Reis Paulo N. B.
Published: July 2024

This review is a fundamental tool for researchers and engineers involved in the design and optimization of fiber-reinforced composite materials. The aim is to provide a comprehensive analysis of the mechanical performance of composites with epoxy matrices reinforced with carbon nanofibers (CNFs). The review includes studies investigating the static mechanical response through three-point bending (3PB) tests, tensile tests, and viscoelastic behavior tests. In addition, the properties of the composites’ resistance to interlaminar shear strength (ILSS), mode I and mode II interlaminar fracture toughness (ILFT), and low-velocity impact (LVI) are analyzed. The incorporation of small amounts of CNFs, mostly between 0.25 and 1% by weight was shown to have a notable impact on the static and viscoelastic properties of the composites, leading to greater resistance to time-dependent deformation and better resistance to creep. ILSS and ILFT modes I and II of fiber-reinforced composites are critical parameters in assessing structural integrity through interfacial bonding and were positively affected by the introduction of CNFs. The response of composites to LVI demonstrates the potential of CNFs to increase impact strength by reducing the energy absorbed and the size of the damage introduced. Epoxy matrices reinforced with CNFs showed an average increase in stiffness of 15% and 20% for bending and tensile, respectively. The laminates, on the other hand, showed an increase in bending stiffness of 20% and 15% for tensile and modulus, respectively. In the case of ILSS and ILFT modes I and II, the addition of CNFs promoted average increases in the order of 50%, 100%, and 50%, respectively.
Recent Advances in the Preparation and Application of Bio-Based Polyurethanes
Authors: Mo Ya , Huang Xiaoyue , Hu Chuanqun
Published: July 2024

Amid environmental pollution and resource depletion, developing and utilizing biomass resources as alternatives to petroleum is a prominent research focus. Driven by environmental protection and sustainable development, the shift from petroleum-based to bio-based polyurethane is a prevailing trend in polyurethane material development. Biomass sources such as vegetable oil, polysaccharides, and lignin offer extensive application prospects in bio-based polyurethane production. Functional modifications of these polyurethanes can further expand their application range. This article explores the preparation of various bio-based polyurethanes, their applications across different fields, and their anticipated future development and uses.
Response Surface Analysis on Multiple Parameter Effects on Borehole Gas Extraction Efficiency
Authors: Cheng Xiaoyu , Cheng Cheng , Xiao Lu , Ma Xingying
Published: July 2024

To explore the impact of different factors on the effectiveness of borehole gas extraction, in situ stress tests were conducted in a test mining area. A theoretical model of gas migration within the coal matrix–fracture system was established. Based on field data, a numerical model was constructed to study the variation patterns of the effective extraction radius under different extraction conditions. Using the response surface methodology, the interactions of different factors and their impact on the effective extraction radius were analyzed, resulting in a response surface model for each factor and the effective extraction radius. The results indicate that the initial permeability of the coal seam has the greatest impact on the extraction radius, with a maximum range of 2.027 m. The influence of extraction time, extraction negative pressure, and borehole diameter decreases sequentially. The borehole diameter has the least impact, with a range of 0.608 m. The response surface model has good significance, with a coefficient of determination (R2) of 0.9957, and it can explain over 99.57% of the response values. The response surface between the initial permeability of the coal seam and extraction time shows the greatest degree of distortion, indicating a significant interaction effect on the extraction radius. In contrast, the response surface between extraction time and extraction negative pressure shows the least degree of distortion, indicating that their interaction effect is the least significant. These findings can provide a theoretical reference for improving borehole design and enhancing gas extraction efficiency.
Vision-Based Formation Control of Quadrotors Using a Bearing-Only Approach
Authors: Ramírez-Parada David L. , Becerra Héctor M. , Toro-Arcila Carlos A. , Arechavaleta Gustavo
Published: July 2024

In this paper, we present a vision-based leader–follower strategy for formation control of multiple quadrotors. The leaders use a decoupled visual control scheme based on invariant features. The followers use a control scheme based only on bearing measurements, and a robust control is introduced to deal with perturbations generated by the unknown movement of the leaders. Using this formulation, we study a geometrical pattern formation that can use the distance between the leaders to scale the formation and cross constrained spaces, such as a window. A condition is defined for which a formation has rigidity properties considering the constrained field of view of the cameras, such that invariance to translation and scaling is achieved. This condition allows us to specify a desired formation where the followers do not need to share information between them. Results obtained in a dynamic simulator and real experiments show the effectiveness of the approach.
System Design of Ocean Temperature Measurement System Using Brillouin Lidar Based on Dual Iodine Cells
Authors: Yang Fu , Chen Wenhao , Liang Luqiang , Fang Chunqi , He Yan
Published: July 2024

Ocean temperature profile information plays a key role in understanding the marine environment. The passive remote-sensing technique can provide sea surface temperature measurements over large areas. However, it is sensitive to the atmospheric environment and cannot provide seawater temperature profile information. The lidar technique is the only way to carry out seawater temperature profile measurements over large areas. However, it is insufficient for measuring speed, the receiving field, stability, spectral integrity, simple system structures, and so on. Therefore, we propose a Brillouin lidar method combining two iodine cells at different temperatures to realize temperature measurements, where one iodine cell is used as a filter to absorb the elastic scattering and the other as an edge detection discriminator to obtain the seawater temperature measurement. The system has a fast measurement speed, a large receiving field, a simple system structure, and high stability. The system feasibility was verified via principle simulation and real iodine absorption curve measurements. For an ocean temperature of [5 °C, 15 °C], a laser wavelength of 532.10495 nm was more appropriate, corresponding to the iodine pool temperature combinations of 50 °C and 78 °C. For an ocean temperature of [15 °C, 32 °C], a laser wavelength of 532.10518 nm was more appropriate, corresponding to the iodine cell temperature combinations of 60 °C and 78 °C. When the laser intensity reached a measurement precision of 1‰, the temperature could be predicted with an accuracy of up to 0.2 K. This work shows promise as a potential solution for seawater temperature profile measurement.
A New and Robust Index for Water Body Extraction from Sentinel-2 Imagery
Authors: Su Zhenfeng , Xiang Longwei , Steffen Holger , Jia Lulu , Deng Fan , Wang Wenliang , Hu Keyu , Guo Jingjing , Nong Aile , Cui Haifu , Gao Peng
Published: July 2024

Land surface water is a key part in the global ecosystem balance and hydrological cycle. Remote sensing has become an effective tool for its spatio-temporal monitoring. However, remote sensing results exemplified in so-called water indices are subject to several limitations. This paper proposes a new and effective water index called the Sentinel Multi-Band Water Index (SMBWI) to extract water bodies in complex environments from Sentinel-2 satellite imagery. Individual tests explore the effectiveness of the SMBWI in eliminating interference of various special interfering cover features. The Iterative Self-Organizing Data Analysis Technique Algorithm (ISODATA) method and confusion matrix along with the derived accuracy evaluation indicators are used to provide a threshold reference when extracting water bodies and evaluate the accuracy of the water body extraction results, respectively. The SMBWI and eight other commonly used water indices are qualitatively and quantitatively compared through vision and accuracy evaluation indicators, respectively. Here, the SMBWI is proven to be the most effective at suppressing interference of buildings and their shadows, cultivated lands, vegetation, clouds and their shadows, alpine terrain with bare ground and glaciers when extracting water bodies. The overall accuracy in all tests was consistently greater than 96.5%. The SMBWI is proven to have a high ability to identify mixed pixels of water and non-water, with the lowest total error among nine water indices. Most notably, better results are obtained when extracting water bodies under interfering environments of cover features. Therefore, we propose that our novel and robust water index, the SMBWI, is ready to be used for mapping land surface water with high accuracy.
Construction of High-Precision and Complete Images of a Subsidence Basin in Sand Dune Mining Areas by InSAR-UAV-LiDAR Heterogeneous Data Integration
Authors: Wang Rui , Huang Shiqiao , He Yibo , Wu Kan , Gu Yuanyuan , He Qimin , Yan Huineng , Yang Jing
Published: July 2024

Affected by geological factors, the scale of surface deformation in a hilly semi-desertification mining area varies. Meanwhile, there is certain dense vegetation on the ground, so it is difficult to construct a high-precision and complete image of a subsidence basin by using a single monitoring method, and hence the laws of the deformation and inversion of mining parameters cannot be known. Therefore, we firstly propose conducting collaborative monitoring by using InSAR (Interferometric Synthetic Aperture Radar), UAV (unmanned aerial vehicle), and 3DTLS (three-dimensional terrestrial laser scanning). The time-series complete surface subsidence basin is constructed by fusing heterogeneous data. In this paper, SBAS-InSAR (Small Baseline Subset) technology, which has the characteristics of reducing the time and space discorrelation, is used to obtain the small-scale deformation of the subsidence basin, oblique photogrammetry and 3D-TLS with strong penetrating power are used to obtain the anomaly and large-scale deformation, and the local polynomial interpolation based on the weight of heterogeneous data is used to construct a complete and high-precision subsidence basin. Compared with GNSS (Global Navigation Satellite System) monitoring data, the mean square errors of 1.442 m, 0.090 m, 0.072 m are obtained. The root mean square error of the high-precision image of the subsidence basin data is 0.040 m, accounting for 1.4% of the maximum subsidence value. The high-precision image of complete subsidence basin data can provide reliable support for the study of surface subsidence law and mining parameter inversion.
Utilizing Multi-Source Datasets for the Reconstruction and Prediction of Water Temperature in Lake Miedwie (Poland)
Authors: Ptak Mariusz , Zhu Senlin , Amnuaylojaroen Teerachai , Li Huan , Szyga-Pluta Katarzyna , Jiang Sun , Wang Li , Sojka Mariusz
Published: July 2024

Water temperature is a fundamental parameter of aquatic ecosystems. It directly influences most processes occurring within them. Hence, knowledge of this parameter’s behavior, based on long-term (reliable) observations, is crucial. Gaps in these observations can be filled using contemporary methodological solutions. Difficulties in reconstructing water temperature arise from the selection of an appropriate methodology, and overcoming them involves the proper selection of input data and choosing the optimal modeling approach. This study employed the air2water model and Landsat satellite imagery to reconstruct the water temperature of Lake Miedwie (the fifth largest in Poland), for which field observations conducted by the Institute of Meteorology and Water Management—National Research Institute ended in the late 1980s. The approach based on satellite images in this case yielded less accurate results than model analyses. However, it is important to emphasize the advantage of satellite images over point measurements in the spatial interpretation of lake thermal conditions. In the studied case, due to the lake’s shape, the surface water layer showed no significant thermal contrasts. Based on the model data, long-term changes in water temperature were determined, which historically (1972–2023) amounted to 0.20 °C per decade. According to the adopted climate change scenarios by the end of the 21st century (SSP245 and SSP585), the average annual water temperature will be higher by 1.8 °C and 3.2 °C, respectively. It should be emphasized that the current and simulated changes are unfavorable, especially considering the impact of temperature on water quality. From an economic perspective, Lake Miedwie serves as a reservoir of drinking water, and changes in the thermal regime should be considered in the management of this ecosystem.
Code-Based Differential GNSS Ranging for Lunar Orbiters: Theoretical Review and Application to the NaviMoon Observables
Authors: Delépaut Anaïs , Minetto Alex , Dovis Fabio
Published: July 2024

In the near future, international space agencies have planned to achieve significant milestones in investigating the utilization of Global Navigation Satellite Systems (GNSS) within and beyond the current space service volume up to their application to lunar missions. These initiatives aim to demonstrate the feasibility of GNSS navigation at lunar altitudes. Based on the outcomes of such demonstrations, dozens of lunar missions will likely be equipped with a GNSS receiver to support autonomous navigation in the lunar proximity. Relying on non-invasive, consolidated differential techniques, GNSS will enable baseline estimation, thus supporting a number of potential applications to lunar orbiters such as collaborative navigation, formation flight, orbital manoeuvers, remote sensing, augmentation systems and beyond. Unfortunately, the large dynamics and the geometry of such differential GNSS scenarios set them apart from current terrestrial and low-earth orbit use cases. These characteristics result in an increased sensitivity to measurements time misalignment among orbiters. Hence, this paper offers a review of baseline estimation methods and characterizes the divergences and limitations w.r.t. to terrestrial applications. The study showcases the estimation of the baseline length between a lunar CubeSat mission, VMMO, and the communication relay Lunar Pathfinder mission. Notably, real GNSS measurements generated by an Engineering Model of the NaviMoon receiver in the European Space Agency (ESA/ESTEC) Radio Navigation Laboratory are utilized. A radio-frequency constellation simulator is used to generate the GNSS signals in these hardware-in-the-loop tests. The performed analyses showed the invalidity of common terrestrial differential GNSS ranging techniques for space scenarios due to the introduction of significant biases. Improved ranging algorithms were proposed and their potential to cancel ranging errors common to both receivers involved was confirmed.
Multi-Teacher D-S Fusion for Semi-Supervised SAR Ship Detection
Authors: Zhang Xinzheng , Li Jinlin , Li Chao , Liu Guojin
Published: July 2024

Ship detection from synthetic aperture radar (SAR) imagery is crucial for various fields in real-world applications. Numerous deep learning-based detectors have been investigated for SAR ship detection, which requires a substantial amount of labeled data for training. However, SAR data annotation is time-consuming and demands specialized expertise, resulting in deep learning-based SAR ship detectors struggling due to a lack of annotations. With limited labeled data, semi-supervised learning is a popular approach for boosting detection performance by excavating valuable information from unlabeled data. In this paper, a semi-supervised SAR ship detection network is proposed, termed a Multi-Teacher Dempster-Shafer Evidence Fusion Net-work (MTDSEFN). The MTDSEFN is an enhanced framework based on the basic teacher–student skeleton frame, comprising two branches: the Teacher Group (TG) and the Agency Teacher (AT). The TG utilizes multiple teachers to generate pseudo-labels for different augmentation versions of unlabeled samples, which are then refined to obtain high-quality pseudo-labels by using Dempster-Shafer (D-S) fusion. The AT not only serves to deliver weights of its own teacher to the TG at the end of each epoch but also updates its own weights after each iteration, enabling the model to effectively learn rich information from unlabeled data. The combination of TG and AT guarantees both reliable pseudo-label generation and a comprehensive diversity of learning information from numerous unlabeled samples. Extensive experiments were performed on two public SAR ship datasets, and the results demonstrated the effectiveness and superiority of the proposed approach.
Ionosphere Monitoring with Remote Sensing Vol II
Authors: Giannattasio Fabio
Published: July 2024

Unveiling the physical properties of the Earth’s ionosphere is crucial for the comprehension of the dynamic processes that occur within it across various spatial and temporal scales [...]