bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxic effect of Imeglimin on T47D and MDA-MB-231 cell Lines of Human Breast Cancer – An In-vitro study
Authors: Ravichandar Ramya , Elango Anitha
Published: November 2024

The aim of this study is to evaluate the in vitro cytotoxic activity of newer antidiabetic drug-Imeglimin by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test on breast cancer cell lines. T47D and MDA-MB-231 breast cancer cell lines were obtained from the NCCS, Pune. Cells (1 × 105/well) were plated in 0.2 ml of medium/well in 96-well plates and were incubated at 5% CO2 for 72 h. Then, various concentrations of the samples were added in 0.1% DMSO for 48h at 5% CO2 incubator. 20µl/well MTT reagent was added after removal of the sample solution and the viable cells were determined by the absorbance at 540nm using UV (Ultra-Violet)-spectrophotometer. The images of the cell viability were viewed under Inverted microscope 40X. Half maximal Inhibitory Concentration (IC50) value was determined graphically. IC50 value of Imeglimin on T47D cells was established at 50µg and that of MDA-MB-231 cells was found to be at 87.5µg respectively. The results revealed that the Imeglimin exerts cytotoxic effect on both the breast cancer cell lines. Its effect on T47D cell line is more when compared to MDA-MB-231 cell line. Hence it may serve as a newer and cost effective treatment strategy for breast cancer patients.
New Preeclampsia Calculated Factor (PF) Detecting Severity in Healthy, Mild and Severe Cases
Authors: K. Jawad Wasan , M. Kadhim Ali , M. Issa Ahmed , S. Zabibah Rahman
Published: November 2024

Preeclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. There is no individual marker satisfactory for the prediction of PE occurrence and many markers have been studied to discover the gold standard test that predicts the boundaries of PE severity. In this comparative case- control study, 118 pregnant women were recruited (44 healthy, 44 with mild PE and 30 with severe PE). The total serum bilirubin, glucose, BUN, total serum protein, albumin, alanine transaminase (ALT), aspartate transaminases (AST), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were measured. There were significant differences in all of the biochemical parameters in the severe PE groups when compared with the healthy control groups; a P value of < 0.001. However, significant associations were not observed for age, gravidity, and gestational age. Three parameters: GGT, total serum bilirubin, and albumin, achieved the highest percent of alteration in relation to healthy control levels; the values 320.66%, 50%, and – 26.21% respectively. These parameters are used to calculate the preeclampsia factor (PF), which was then engaged in detecting the boundary lines of PE groups and the interference areas or overlapping between peaks. The gathering of many biochemical parameters in one equation is a good approach to produce a factor that represents a reliable biochemical tool used successfully to outline the boundaries of PE groups and display the areas of overlap between them. This preeclampsia factor is a promising biochemical tool in patient monitoring, treatment, follow-up, and facilitating pregnant health care.
Correlation between Serum Ferritin level and Immature Reticulocyte Fraction (IRF) in Children with Beta Thalassemia Major
Authors: Widyastuti Erlinda , B. Notopuro Paulus , Ratwita Mia , A. Rahman Annisa , Soneta Miyayu , E. Rochmi Siti
Published: November 2024

Blood transfusion is the primary therapeutic approach for patients diagnosed with beta thalassemia major. However, this treatment can lead to the accumulation of toxic iron in various organs such as the liver, heart, endocrine system, and bone marrow, causing tissue damage. Damage to the bone marrow results in the suppression of erythropoiesis. The serum ferritin level is an unreliable indicator of total body iron levels since it is a positive acute phase protein which limits its use for diagnosis. Moreover, examining serum ferritin levels can be costly and not widely available. In contrast to serum ferritin levels, Immature Reticulocyte Fraction (IRF) is an early indicator of erythropoiesis activity that reduces iron overload and does not react significantly during acute-phase responses. Additionally, IRF parameters are already present in hematology analyzers, however their optimization has been limited by lack of investigation into their utility for examination purposes. Therefore, this study aims to investigate the correlation between serum ferritin levels and IRF values among children diagnosed with beta thalassemia major. The study design was a cross-sectional approach. Subjects consisted of 55 cases of children with beta thalassemia major who came to the Hemato-Oncology Outpatient Clinic in the Pediatric Department of one of the hospitals in Surabaya, East Java, Indonesia. Levels of serum ferritin were measured using ECLIA (Electrochemiluminescence immunoassay) methods, while IRF was measured via flowcytometry. The results were statistically analyzed using Spearman correlation test. In children with beta thalassemia major, levels of serum ferritin ranged from 358ng/mL to 5696ng/mL, with an average value of 2542.760ng/mL and a standard deviation of 1279.850ng/mL being recorded. Immature Reticulocyte Fraction (IRF) varied from 1.600% to 34.300%, having an average value of 15.240% and a standard deviation amounting to 6.228%. Correlations were shown between serum ferritin levels and IRF with a correlation coefficient (r) of - 0.369 and a p-value of 0.006. There was a negative correlation between serum ferritin levels and IRF. It was found that the higher serum ferritin levels, the lower the IRF.
Exploring the Potential of Bioactive Metabolites in COVID-19 Management through main Protease Enzyme (MPRO) Inhibition
Authors: Ratre Manorama , Jain Ritesh , Ahirwar Dheeraj , Rathore Hemlata , Sahu Geetanjali , Ahirwar Bharti , Kumar Sahu Suresh
Published: November 2024

The COVID-19 pandemic has spurred global efforts to identify effective therapeutic strategies. One promising avenue involves exploration of bioactive metabolites as potential inhibitors of main protease enzyme (Mpro) of SARS-CoV-2 virus. Mpro plays a critical role in viral replication and is considered a prime target for drug development.This review delves in potential of bioactive metabolites in managing COVID-19 by inhibiting Mpro. Bioactive metabolites are naturally occurring compounds found in various organisms, including plants, fungi, and marine life, known for their diverse biological activities. They have shown promise in inhibiting enzymatic activity of Mpro, disrupt viral replication-mitigate infection. This study explores a wide range of bioactive, sources, and inhibitory effects on Mpro. It investigates mechanisms of action and binding affinities of these metabolites, shedding light on their potential as anti-COVID-19 agents. Moreover, the review discusses the development of bioactive metabolite-based drugs and their safety and efficacy in COVID-19 management. By elucidating the potential of metabolites in inhibiting Mpro, this review contributes to the development of novel therapeutic interventions for COVID-19, offering hope in the battle against ongoing pandemic. These findings may pave the way for development of effective treatments that can complement existing strategies in the fight against SARS-CoV-2.
Molecular Docking Study of Siddha Herbal Formulation Kurudhiazhal Choornam against Hypertension
Authors: Chitra S. M.
Published: November 2024

Introduction: Hypertension is one of the most common non communicable disease that affects the world’s population leading to Cardio vascular disease. Despite, so many modern drugs prevalent in the market, due to their side effects people are in search for herbal remedies. Siddha medicine, an ancient Tamil medical system was rich in herbal, metal and mineral origin drugs for prevention and the treatment of various disorders encompassing non communicable diseases. Kurudhiazhal choornam, a Siddha herbal proprietary formulation was prescribed widely for systemic hypertension in Siddha wings of Government sector, Tamil Nadu for many years. The formulation was effective for the management of hypertension but its mechanism in reducing the blood pressure was not explored. As an initiative, a preliminary molecular docking study through computational analysis was done with Auto Dock tool to find its action in reducing the blood pressure. Materials and methods: The phytoconstituents present in each ingredient of Kurudhiazhal choornam were identified and retrieved through literature survey. The potential action of Kurudhiazhal choornam against Hypertension was compared with allopathy standard drug captopril for inhibitory action of Angiotensin-converting enzyme (ACE). Results: Study results showed, phytoconstituents present in the individual ingredients of the formulation Kurudhiazhal choornam has effective binding action against ACE receptor target. Conclusion: The Siddha formulation Kurudhiazhal choornam has inherent action against hypertension by binding with ACE receptor target enzyme was concluded by the present study.
RP-HPLC Method Development and Validation for Simultaneous Estimation of Mirabegron and Silodosin in Synthetic Mixture
Authors: V. Dudhrejiya Ashvin , B. Pithadiya Shivangi , J. Vyas Amitkumar , K. Patel Nilesh , I. Patel Ajay , B. Gavit Hetal , A. Gol Dhruvanshi
Published: November 2024

Background: The primary objective of the present study of RP-HPLC technique by utilizing a UV detector that possesses characteristics of simplicity, sensitivity, speed, accuracy, and precision. The present study employed a methodology to concurrently determine the quantities of Mirabegron and silodosin within a synthetic blend. Material and Method: RP-HPLC Method was developed by using isocratic elution mode. Using an OROSIL C18 column that measured 150mm in length, 4.6mm in Column inside Diameter (ID), and 3µm in particle size, the materials were separated by liquid chromatography. The mobile phase employed was a blend of methanol and phosphate buffer at a 60:40% v/v ratio. And 0.5ml/min wasflowing rate, the separation was accomplished. Using a UV detector, all of the compounds were identified and measured at a wavelength of 270nm. Result: For Mirabegron and Silodosin, the linearity of the technique was seen within the range of concentration for 6.3-150 ppmand 2-48µg/ml, respectively. The range of percentage recovery for Silodosin was 98.05% to 100.23%, and for Mirabegron it was 98.86% to 100.64%. The methodology was verified in compliance with the International Council on Harmonization's criteria (Q2R1). Conclusion: The suggested RP-HPLC technique is highly appropriate for analyzing Mirabegron and Silodosin, as it guarantees precise findings without any interference.
सतत विकास के लिए उद्यमिता की भूमिका
Authors: सिंह गुरुपंच कुबेर
Published: November 2024

प्रस्तुत अध्ययन का उद्येष्य सतत विकास के लिए उद्यमिता की भूमिका का विष्लेषण करना है, यह द्वितीयक आंकड़ों पर आधारित है।सतत विकास लक्ष्य (एसडीजी) संयुक्त राष्ट्र के एजेंडा 2030 का एक मूलभूत हिस्सा हैं और वैश्विक विकास के संदर्भ में 21वीं सदी की शुरुआत को आकार देंगे। एसडीजी तीन विषयगत स्तंभों, सामाजिक, आर्थिक और पर्यावरण पर आधारित हैं, जिसमें इन उद्देश्यों की दिशा में प्रगति को मापने के लिए 17 लक्ष्य और 169 संकेतक शामिल हैं एसडीजी की परस्पर संबद्धता के लिए उनके कार्यान्वयन के लिए एक वैश्विक रणनीति की आवश्यकता होती है, क्योंकि सभी लक्ष्य परस्पर जुड़े हुए हैं और उन्हें अलगाव में हासिल नहीं किया जा सकता है। एसडीजी गरीबी, शिक्षा, स्वास्थ्य, लैंगिक समानता, पर्यावरण और मानवाधिकारों सहित सामाजिक, आर्थिक और पर्यावरणीय मुद्दों की एक विस्तृत श्रृंखला को संबोधित करने के लिए एक व्यापक ढांचा प्रदान करते हैं एसडीजी सार्वजनिक और निजी सामाजिक हस्तक्षेप दोनों के लिए चुनौतियां पैदा करते हैं, जिनमें सामाजिक कार्य क्षेत्र भी शामिल हैं, जो अक्सर सामाजिक मुद्दों के प्रति अपने दृष्टिकोण में खंडित होते हैं सामाजिक कार्य ने स्वयं को एक ऐसे पेशे के रूप में स्थापित किया है जिसकी एसडीजी के वांछित परिणामों को प्राप्त करने में महत्वपूर्ण भूमिका है।
Differential Expression of VrNAC Genes in Shoot and Root Tissues of Mung Bean Grown Under Drought Condition
Authors:   Professor Molecular Biology Laboratory Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh., Riazul Islam Mohammad , Hossain Mohammad Zabed ,   Ecology and Environment Laboratory, University of Dhaka Dhaka, 1000, Bangladesh.
Published: November 2024

Mung bean (Vigna radiata L.) is an economically, nutritionally and ecologically important legume crop, cultivated in East, Southeast and South Asian countries. Drought affects the production of mung bean by altering its growth at various stages of its lifecycle.
Traditional Storytelling and Immersive Narratives in the Metaverse
Authors: Anushruti Gantayat, Prajna Pani, Swetalina Mishra
Published: November 2024

This paper explores the evolution of storytelling by comparing traditional narrative forms with immersive storytelling in the Metaverse. Traditional storytelling, rooted in oral traditions, literature and theatre, relies on a linear, author-driven structure that presents a fixed story to the audience, fostering social cohesion and conveying cultural values. Metaverse, a digital universe with virtual reality (VR), augmented reality (AR) and interactive technologies enables users to actively engage and shape the narrative. This shift allows users to move beyond passive observation, introducing new levels of interaction and engagement that reshape storytelling. The study examines four key dimensions where traditional storytelling diverges from metaverse-based narratives: agency, interactivity, immersion and community. In traditional formats, the audience’s role is passive, while the storyteller retains control of the plot. However, the Metaverse allows users to influence story progression, creating a more personalized experience. While traditional stories rely on imagination, the Metaverse employs VR and AR to immerse users fully, fostering a sense of presence and heightening emotional impact. This engagement is achieved through visual, auditory and sometimes tactile elements that make users feel like they inhabit the story world, enhancing empathy and emotional depth. Community experiences diverge traditional storytelling often unite audiences through shared cultural narratives, while the Metaverse allows for communal, multiplayer storytelling experiences that redefine cultural bonds within digital spaces. This study suggests a hybrid storytelling approach that combines the immersive power of the Metaverse with traditional narrative integrity, offering a framework for future narratives that balance interactivity and structured storytelling.
Protective and curative effects of Phuong Dong Dai Trang tablets on an experimental model of irritable bowel syndrome
Authors: Tung Tran Thanh , Van Anh Pham Thi , Duong Dau Thuy
Published: November 2024

Phuong Dong Dai Trang tablet is a mixture of medicinal herbs including Hedychium coronarium, Coix lacryma-jobi, Dioscorea persimilis, Cynara Scolymus L., Paeonia lactiflora, and Glochidion eriocarpum. This study was carried out to evaluate the protective and curative effects of Phuong Dong Dai Trang tablets on mustard oil-induced irritable bowel syndrome model in mice. Swiss mice were divided into six groups that were given orally 0.9% sodium chloride (group 1 - 3), Duspatalin (mebeverine) 80 mg/kg b.w./day (group 4), Phuong Dong Dai Trang tablets 1080 mg/kg b.w./day (group 5) and Phuong Dong Dai Trang tablets 3240 mg/kg/b.w./day (group 6). Mice of group 3 - 6 were induced diarrhea-predominant irritable bowel syndrome by mustard oil colonic administration before or after oral treatment. The research indices included the intestinal motility measured by charcoal meal test, colon macroscopic and microscopic scores. Our findings showed that Phuong Dong Dai Trang tablets at 3240 mg/kg b.w./day reduced the intestinal motility and the stool score significantly in mice. Phuong Dong Dai Trang tablets at 1080 mg/kg b.w./day improved the stool score and tended to decrease the intestinal motility in mice.
The efficacy of rituximab in the treatment of refractory chronic inflammatory demyelinating polyneuropathy in children: A report of three cases from Northern Vietnam
Authors: Van Nguyen Thi Bich , Dung Le Thi Thuy , Phuong Vu Thu , Hung Cao Vu , Huong Do Thanh , Van Nguyen Thi , Tuan Ta Anh , Nguyet Dao Thi
Published: November 2024

Rituximab has been reported to be effective in patients with refractory CIDP, especially those with IgG4 autoantibodies against nodal and paranodal proteins. This study reports the clinical characteristics of three cases diagnosed with refractory CIDP successfully treated with rituximab, although testing for IgG4 antibodies is currently not available in Vietnam. Patients were evaluated using the MRC (Medical Research Council Scale for Muscle Strength) and INCAT (Inflammatory Neuropathy Cause and Treatment) scores before and after rituximab treatment. The duration of the disease before rituximab treatment ranged from 6 to 10 months, with total MRC scores of 16 - 26 points, INCAT scores of 8 - 9 points, and the first response noted after 1 - 4 months. Patients recovered well after a follow-up period of 8 to 12 months without adverse effects, with MRC and INCAT scores improving to 48 - 58 points and 1 - 2 points, respectively. Rituximab may be effective in treating refractory CIDP patients.
Evaluating the result of cytoreductive surgery after neoadjuvant chemotherapy in advanced epithelial ovarian cancer
Authors: Ty Ngo Van , Hau Nguyen Xuan , Huyen Phung Thi
Published: November 2024

A retrospective study of 61 patients was conducted to evaluate the preliminary results of maximal cytoreductive surgery following neoadjuvant chemotherapy for FIGO stage IIIC-IV ovarian cancer from 2019 to 2023. The patients were diagnosed with FIGO staged IIIC (54.1%) and IV (45.9%), confirmed by preoperative histopathology. Elevated CA 125 level (> 1000 UI/ml) was found in 45 patients (73.8%). The rate of patients achieving optimal surgery was 80.4%. The mean surgery time was 134.1 ± 39.1 minutes, the average blood loss in 1 surgery was 171.2 ± 144.9mL. The drainage volume during the first 3 days was 115.4 ± 38.1mL. The patient started passing gas 3.9 ± 1.0 days after surgery, and started walking after 8.3 ± 2.0 days. The discharged day was 10.1 ± 2.1 days. After surgery, only 1 patient had intestinal obstruction, 2 patients had infection, 2 patients had bleeding, 1 patient had bladder dysfunction, and the remaining patients were stable postoperatively.
性平議題融入教材所涉之文化現象討論—以108課綱翰林版國中國文第六冊自學選文〈捍衛性別平權的鬥士—金斯伯格〉為例
Authors: 陳怡芬 陳怡芬
Published: November 2024

教科書除了是國家機器統治工具之一，同時也展現社會文化，更是師生教與學經驗的主要連結。中學國文教科書係以選文型的編輯型態為主軸，除了要切合課綱也需符應時代趨勢；選文確定後則進一步影響第一線授課內涵。《十二年國民基本教育課程綱要》施行後，以十九大議題融入以培養學生批判思考及解決問題的能力，議題融入成為教材編選考量。其中性別平等為首要議題。翰林出版社於其國語文第六冊自學選文〈捍衛性別平權的鬥士－－金斯伯格〉篇目中明確點出「性別議題」。日前「性平教育」中涉及「多元性別認同」的部分仍充滿爭議，中學教材編選如何兼顧課綱及相關爭議性？本論文收集相關資料進行分析，爬梳教材文本，討論該篇選文與課綱及《性別教育平等法》之間的相關性，以及其代表的社會文化面貌。

 

In addition to being a tool of the government, textbooks also reflect social culture and serve as a main link between teachers and students’ teaching and learning experiences. Middle school Chinese textbooks focuses on the editing style of selected texts. In addition to fitting the requirements of the national curriculum, textbooks must also conform to contemporary trends. After the selection of texts is confirmed, front-line teaching will also be affected. After the implementation of the “Curriculum Guidelines of 12-Year Basic Education,” integration of 19 core issues was proposed in order to cultivate students’ critical thinking and problem solving abilities. Among these, gender equality is the most important issue. The Hanlin Publishing Company included a self-study article “Gingsberg: A Fighter for Gender Equality” in the sixth volume of their Chinese language textbook, with “gender issues” clearly indicated in the title. Currently, the inclusion of multiple gender identities in “gender equality education” remains controversial. How should the compilation of middle school textbooks take into account both the national curriculum and relevant controversies? This study collects relevant data for analysis, combing through the text of textbooks, and discusses the correlation between the selected texts, the national curriculum and the “Gender Education Equality Act,” as well as the social and cultural outlooks represented.

 
Verdien av et tverrfaglig semester, slik studentene ser det
Authors: Sandtrø Tengel
Published: November 2024

På politisk nivå, og innen privat næringsliv, omtales tverrfaglighet som en del av løsningen på gjenstridige problemer. Et tiltak kan være å tilby tverr-faglige utdanninger, men disse byr på noen utfordringer; dybdeforståelsen kan måtte ofres når tiden må brukes på å få oversikt over et mye bredere felt av fag eller disipliner. Vinteren 2024 blusset det opp en diskusjon om tverrfaglige utdanninger, da det ble antydet at noen handlet mer om student-rekruttering enn egenverdi. Denne artikkelen tar for seg et tverrfaglig semes-teremne, og dokumenterer hvordan prosjektbasert læring i denne konteksten fungerer som pedagogisk verktøy for å oppnå høy opplevd verdi for tekno-logistudentene som deltar. Målsetningen for semesteret er i stor grad sam-menfallende med målene for tverrfaglige utdanninger, med den ulikheten at i det aktuelle emnet er studentene allerede i sitt tredje eller fjerde år i en inge-niør- eller teknologiutdanning. Prosjektbasert læring (PjBL) har både ut-fordringer og styrker, og studentenes egen opplevelse av verdi er ikke et per-fekt mål. Likevel argumenterer artikkelen for at PjBL er et godt pedagogisk verktøy og at studentene har en realistisk og relevant forventning til denne typen emner.
Using Microsoft Copilot Chat in the Work of IT Educators: Pilot Study
Authors: Osadcha Kateryna , Szynkiewicz Justyna , Chishti Mohd Sameen
Published: November 2024

Artificial intelligence (AI) chatbots have recently emerged in nearly all aspects of life, including education, where educators are exploring their potential. However, achieving proficiency remains a challenge due to numerous hurdles. This article aims to identify the problems IT educators face when using AI chatbots and propose solutions. We used Scopus, Web of Science, and Scopus AI to explore how IT educators use AI chatbots and the problems they face. Additionally, we developed and implemented the Microsoft Copilot Chat user guide, and conducted a workshop at our institution on using Microsoft Copilot Chat for professional activities of IT educators. Findings from the literature and the pre- and post-workshop surveys provided firsthand insights into educators' knowledge, usage patterns, and the drawbacks of using Microsoft Copilot Chat. The literature review shows that educators mainly use AI to generate ideas, grade assignments, and automate tasks, while also valuing AI chatbots for personalized learning. However, problems include a lack of guidelines, identifying AI use in student work, and potential impacts on critical thinking. Additionally, a workshop on the use of Copilot for professional activities was conducted, accompanied by pre- and post-surveys with questions inspired by findings from the literature. One of the important findings of the surveys is that most educators use AI chatbots and are knowledgeable about their capabilities, except for areas like image quality assessment and emotion detection. Lastly, McNemar test was conducted to assess the workshop's impact, revealing significant improvements in participants' knowledge of AI chatbots capabilities and suggesting a positive influence on their future use of these tools. Conclusions were made regarding the improvement of the Copilot guide content and method of conducting the workshop for future research.
Comunicación universitaria en la ecología mediática desde sus audiencias y prosumidores: una estrategia metodológica
Authors: León Barrios Gerardo Guillermo
Published: November 2024

Este artículo presenta un modelo metodológico que permite conocer cómo se diseñó el estudio sobre el Sistema de Comunicación Universitario de la Universidad Autónoma de Baja California. Se parte de la perspectiva analítica de la ecología mediática como un complejo sistema simbólico en donde audiencias y prosumidores usan, apropian, crean y maneja el sistema de comunicación institucional. Bajo estas premisas, se describen las decisiones en los componentes fundamentales de la estrategia metodológica como marco epistémico, programa de investigación, protocolo, instrumentos, modelo de análisis con el uso de cinco categorías arropadas por mi propia reflexividad metodológica.
Silver-Platinum Hollow Nanoparticles as Labels for Colorimetric Lateral Flow Assay
Authors: Zhou Jinfeng , Shao Shikuan , Wei Zhiyuan , Xia Xiaohu
Published: November 2024

Article
Silver-Platinum Hollow Nanoparticles as Labels for Colorimetric Lateral Flow Assay

Jinfeng Zhou 1, Shikuan Shao 1, Zhiyuan Wei 1 and Xiaohu Xia 1,2,*

1 Department of Chemistry, University of Central Florida, Orlando, FL 32816, USA
2 NanoScience Technology Center, University of Central Florida, Orlando, FL 32816, USA
* Correspondence: xiaohu.xia@ucf.edu
Received: 23 September 2024; Revised: 7 November 2024; Accepted: 12 November 2024; Published: 18 November 2024
 

Abstract: Colorimetric lateral flow assay (CLFA) has been a widely recognized point-of-care testing technology over the past few decades. Driven by the increasing demand in various biomedical applications, it is urgently needed to develop CLFAs with high sensitivities and low costs. In this work, we report a type of CLFA that relies on unique colorimetric labels—silver-platinum hollow nanoparticles (Ag-Pt HNPs). The Ag-Pt HNPs possess intrinsic enzyme-like catalytic activities, providing the Ag-Pt HNP-based CLFA with strong color signal and thus a high sensitivity. Meanwhile, the Ag-Pt HNPs have hollow interiors and are mainly composed of less expensive silver, making the Ag-Pt HNP-based CLFA cost-effective. Using prostate-specific antigen (PSA) as a model disease biomarker, the Ag-Pt HNP-based CLFA achieved a high sensitivity with a detection limit at the low picogram-per-milliliter level. Potential application of the CLFA in clinical diagnosis was demonstrated by detecting PSA from human serum samples.
Inovações na Engenharia Civil: uma análise das novas tendências em materiais de construção
Authors: Pereira Solany Santos , Costa Alice Noronha da , Dias Matheus Francisco de Souza , Assis Vitoria dos Santos , Santos Raquel Gomes dos , Dall’Oca Gabriel Shmayev , Santos Raissa Gomes dos , Serafini Ramoel
Published: November 2024

Este estudo investiga os avanços recentes em materiais de construção, examinando sua relevância na engenharia civil contemporânea. Inicialmente, contextualiza-se a importância dos materiais de construção em várias aplicações, realçando seu papel na segurança, sustentabilidade e qualidade das estruturas. O estudo visa analisar as tendências e avanços nesse campo, com o objetivo geral de avaliar seu impacto na eficiência, sustentabilidade e desempenho das estruturas. Para alcançar esse objetivo, foram estabelecidos objetivos específicos, incluindo revisar a literatura existente sobre materiais inovadores, analisar benefícios e desafios associados à sua adoção e identificar oportunidades futuras de pesquisa. A metodologia adotada baseou-se em uma revisão bibliográfica abrangente de fontes acadêmicas relevantes, permitindo uma compreensão profunda das tendências atuais e futuras neste campo. Os resultados destacam a importância da inovação na busca por soluções que atendam aos desafios da engenharia civil moderna, enfatizando a diversidade de abordagens adotadas para promover ambientes construídos mais seguros, eficientes e sustentáveis. Em suma, o estudo demonstra como a evolução na construção civil é impulsionada pela busca por materiais mais duráveis, confiáveis, sustentáveis e eficientes. As inovações apresentadas refletem um compromisso crescente com práticas construtivas mais ecológicas e eficientes, contribuindo para o avanço contínuo da construção sustentável e eficiente.
Model to study (Na+, K+)-ATPase activation in human peripheral blood mononuclear cells and MCF-10A mammary cells by the PEG-Melatonin conjugate
Authors: Mesquita Juliana Luzía França , Botelho Aline do Carmo França , França Emanuelle Carolina Honorio , França Danielle Cristina Honorio , Souto Paula Cristina de Souza , França Eduardo Luzía , Honorio-França Adenilda Cristina
Published: November 2024

Polyethylene glycol (PEG) microsphere-modified release systems have been used for adsorption on molecules, proteins, and hormones. Melatonin (N-acetyl-5-methoxytryptamine) is a biogenic amine that regulates the activity of (Na+, K+)-ATPase. The non-tumorigenic nature of MCF10 cells can be a model for studying several biological systems, such as blood mononuclear cells. In this sense, the objective of this study was to evaluate the effects of melatonin nanofractions adsorbed to PEG microspheres on ATPase enzymes in human blood mononuclear cells and MCF-10A mammary cells. Human blood mononuclear cells and MCF-10A mammary cells (ATCC) were used. The cells were tested for (Na+, K+)-ATPase activity. It was observed that there was an increase in the enzyme in mononuclear cells that were incubated with melatonin adsorbed to the PEG microsphere. There was an increase in the enzymatic activity in MCF-10A when melatonin adsorbed to the PEG microsphere. The PEG microsphere increased the specific activity of Na+/K+-ATPase in human blood mononuclear cells. In MCF-10A mammary cells, there was no change in the presence of the PEG microsphere and a reduction in the presence of melatonin. When these cells were incubated with melatonin adsorbed to the PEG microsphere, there was an increase in the activity of Na+/K+-ATPase. The differences in enzymatic activity suggest that both cell models can serve as models to evaluate the functional activity of cells, cytotoxicity, and interactions between cells in the presence of immunomodulatory agents, thereby contributing significantly to our understanding of these processes.
Arranjos institucionais e regimes urbanos: a verticalização do setor de serviços e comércio em imperatriz (MA)
Authors: Silveira Keilha Correia da , Pimentel Neto José Geraldo , Andrade Tiago da Silva , Silva Tiago dos Santos da
Published: November 2024

A pesquisa insere-se na discussão sobre o gerenciamento do espaço urbano, considerando fatores de dinamicidade econômica, política e social no contexto da criação de novas formas de colaboração e competição. No cenário brasileiro, acrescenta-se à discussão o delineamento das relações no âmbito da Governança Urbana, a partir da Constituição de 1988 e da descentralização do poder ocorrida, especialmente no que diz respeito à autonomia dos municípios e às novas práticas de configuração do espaço urbano sob a lógica capitalista, na perspectiva das coalizões institucionais. Diante da temática apresentada, a pesquisa busca realizar uma análise qualitativa por meio da metodologia de estudo de caso, com o objetivo de entender essa questão, visando compreender os Arranjos Institucionais e os Regimes Urbanos na perspectiva da governança da cidade de Imperatriz/MA. O foco recai sobre o processo de verticalização do setor de serviços e comércio, verificando as dinâmicas das coalizões institucionais a partir do planejamento e da gestão urbana. Os resultados do estudo revelaram a identificação de 10 edifícios dentro do critério de análise, embora nem todos tenham possibilitado a verificação das características de articulações e coalizões presentes. No entanto, em alguns casos, foi possível identificar coalizões que influenciaram o crescimento urbano de Imperatriz.
Effects of sugarcane molasses application on soybeans growth and yield after a period of drought stress
Authors: Duarte Mateus Dias , Santos Agna Eduarda Moreira dos , Almeida Isaías Alves de , Lima Paulo Cesar Sousa , Bernado Wallace de Paula , Rocha Tiago Cunha , Nunes Járisson Cavalcante , Rodrigues Weverton Pereira
Published: November 2024

The objective of the present study was to investigate the effect of application of sugarcane molasses foliar spray earlier after a period of drought stress on soybean growth and yield. The experiment was conducted in the municipality of Itinga, Maranhão, Brazil, using the soybean Brasmax Olimpo IPRO genotype. The row spacing was 0.50 m, and the number of seeds per meter was calculated based on the seed's germination capacity to achieve 14 plants per meter of row. The experimental design was a randomized block design with two treatments: molasses application either 2 or 7 days after precipitation, with four plots. The applications took place after a period of 28 days without rain. Leaf area, plant dry mass, and yield measurements were taken during the R5 reproductive stage—beginning of seed filling. Dry mass was measured after drying in a forced-air circulation oven at 70°C for 72 hours. The plot treated with sugarcane molasses resulted in greater productivity due to increased photoassimilates allocation to the grains.
Lstyle : construção de uma ferramenta tecnológica para identificação de estilos de aprendizagem
Authors: Ito Giani Carla , Brasil Guilherme Wilgner Santos , Schneider Eduarda Maria , Damke Anderleia Sotoriva , Silva Rafael Azevedo da , Barbacovi Vinícius Paulo , Pereira Mayara Rodrigues
Published: November 2024

Este artigo apresenta o desenvolvimento da ferramenta LSTYLE, projetada para identificar os estilos de aprendizagem dos estudantes, utilizando o modelo de David Kolb e de Honey-Alonso. A ferramenta foi construída com uma interface intuitiva e acessível, permitindo o diagnóstico automatizado dos estilos de aprendizagem predominantes entre os alunos. O objetivo da ferramenta é apoiar práticas pedagógicas mais inclusivas e personalizadas, facilitando a adaptação das estratégias de ensino conforme os diferentes perfis de aprendizagem. Assim, educadores podem promover um ambiente adequado aos estudantes. Os relatórios gerados pela ferramenta oferecem aos educadores uma visão clara das preferências de aprendizagem dos discentes, permitindo ajustes na abordagem pedagógica para melhorar o engajamento e a eficácia do ensino. A ferramenta permite ainda a exportação de relatórios em diversos formatos, como Excel, PDF e JSON, o que facilita o acompanhamento e a análise dos dados obtidos, promovendo uma gestão educacional mais eficiente e alinhada às necessidades dos alunos.
Inovação no setor público para a promoção de qualidade de vida nas cidades: compreendendo a literatura da inovação
Authors: Maia Nathália Costa , Nascimento Alex Bruno Ferreira Marques do , Maracajá Kettrin Farias Bem
Published: November 2024

O presente trabalho consiste em analisar a bibliografia que compõe a produção e mostra de que maneira a inovação no setor público promove a qualidade de vida nas cidades. A metodologia se caracteriza por uma bibliometria enquadrando-se como quantitativa exploratória através de um processo de levantamento da produção indexado nas bases de dados selecionados no interstício de 1999 e 2023. Os principais resultados apontam que apesar das pesquisas já percebam o cidadão como um ator diferencial no fomento das inovações no setor público nas cidades, o tema necessita de debate relacionado a aplicação técnica da inovação em relação à sua absorção na comunidade. A principal limitação do estudo é constituída pela amostra. Os achados deste artigo fornecen base científica aos futuros estudos empíricos que buscam preencher a lacuna que indica um aprofundamento da qualidade de vida nas cidades através das inovações propostas pelo âmbito público, abordando o fenômeno sob diferentes realidades sociais.
Study on the Problems and Countermeasures of Endowment Insurance Participation of Urban Flexible Employees
Authors: Li Mingcheng , Liu Leye
Published: November 2024

Given the numerous ways in which flexible employment differs from traditional mainstream employment methods, the task of providing social security for flexible employees is often more intricate. Consequently, this article takes urban flexible employees in Z city as a case study to delve into the challenges faced by flexible employees in participating in endowment insurance and proposes corresponding solutions to these challenges. It is my hope that all flexible employees can be encompassed within the social security system, ensuring that they have someone to support and rely on in their twilight years.
Study on Social Work Intervention in Social Integration of Migrant Children
Authors: Wang Yan
Published: November 2024

With the rapid economic development of China, large-scale population migration has become a normalized feature of population development. Under such circumstances, the social integration of migrant children has become a hot topic in the academic world. Migrant children are a special group generated in the urbanization process in China. Facing the new culture, order, and social environment, migrant children need to adjust their original way of life and adapt to a new life and study in the place of influx. As we all known, children are in the key stage of physical and mental development and socialization. They will face many difficulties in integrating into the new environment, due to their weak adaptive ability. Therefore, this paper analyzes the current situation of migrant children and comes up some strategies to help the migrant children under the guidance of ecosystem theory.
Analyzing Chinese-to-Japanese Translation Through the Lens of Expressive Characteristics
Authors: Zhou Qian
Published: November 2024

The differences in expressive styles between Chinese and Japanese present challenges in achieving accurate and nuanced translation between the two languages. Relying solely on conventional translation techniques often fails to fully convey the intended meaning. By skillfully leveraging the structural and stylistic differences between Chinese and Japanese, translations can avoid excessive verbosity and unnatural phrasing, resulting in more fluent and precise renditions. This paper synthesizes prior studies on Chinese-to-Japanese translation and focuses on exploring the structural and expressive characteristics of the two languages. Using examples from textbooks, it examines the translation of Chinese complement constructions and the correspondence between Japanese thematic sentences, objective descriptive sentences, and their counterparts in Chinese. The study concludes by identifying unresolved issues in Chinese-to-Japanese translation that merit further investigation.
Research on Scarcity in International Relations
Authors: Wang Qifan
Published: November 2024

The main issue of research is the scarcity problem that exists in international relations. The purpose is to explore whether scarcity and the problems it brings can be eliminated in international relations. In the research, the main methods used were literature collection, analysis, and extended argumentation. It mainly uses data from books on international relations and related literature. The research results show that scarcity holds a unique and important position in international relations, which cannot be eliminated. Meanwhile, it is more of a means that can be applied to competition between countries. Wrong cognition and psychology, irrational decisions and actions. Ultimately, it led to the scarcity of resources and the outbreak of crises. This article mainly provides a new perspective for the analysis and research of past international relations history and relevant current political cases. Simultaneously providing reference for national diplomacy and international competition strategies.
Risks of Generative Artificial Intelligence and Multi-Tool Governance
Authors: Hu Fangfei , Liu Shiyuan , Cheng Xinrui , Guo Pengyou , Yu Mengqi
Published: November 2024

While generative AI, represented by ChatGPT, brings a technological revolution and convenience to life, it may raise a series of social and legal risks, mainly including violation of personal privacy and data security issues, infringement of intellectual property rights, generation of misleading and false content, and exacerbation of discrimination and prejudice. However, the traditional AI governance paradigm oriented towards conventional AI may not be adequately adapted to generative AI with generalized potential and based on big models. In order to encourage the innovative development of generative AI technology and regulate the risks, this paper explores the construction of a generative AI governance paradigm that combines legal regulation, technological regulation, and ethical governance of science and technology, and promotes the healthy development of generative AI on the track of safety, order, fairness, and co-governance.
Research on the Innovative Path of College Students' Employability Cultivation from the Perspective of New Quality Productivity
Authors: Li Hua
Published: November 2024

With the rise of new quality productivity, the economic development model and industrial structure have undergone profound changes, which put forward new requirements for college students' employability. Driven by innovation as the core, the new quality productivity is characterized by high-tech content, high efficiency and high quality, which has a profound impact on the industrial structure and job market demand. This paper analyzes the opportunities and challenges brought by the rapid development of new quality productivity to the employment of college students, and then discusses the innovative path for the training of college students' employability, including the construction of dynamic knowledge and skills training system, the construction of all-round comprehensive quality and ability improvement platform, psychological support and the collaborative model of competitive advantage building, aiming to improve the employment competitiveness of college students in the environment of new quality productivity. In order to better adapt to the high-quality economic development of the demand for talents, but also for the university employment guidance and personnel training strategy adjustment to provide useful reference.
Research on Enhancing the Effectiveness of Supervision on the "Key Few" Leadership Personnel
Authors: Luo Xiaolong , Liu Zhesi , Zhang Yuxiang , Song Li
Published: November 2024

The management of private overseas travel for leaders is an important part of internal Party supervision and a key link in the supervision of cadres. Strengthening the management of private overseas travel for leaders can help curb unwholesome practices and corruption in the cadre team, enhance the overall level of cadre quality, and improve Party-mass relations. It has significant implications for the smooth advancement of Party building work in China. Currently, there are blind spots in the specific implementation of the management of private overseas travel for leaders, with some leaders even harboring a lucky mentality and refusing to comply with the regulations, which may lead to oversights and even serious loopholes in actual operation, thereby causing adverse consequences.
Research on the Impact of Digital Finance on High Quality Development of Enterprises
Authors: Jiang Chengda
Published: November 2024

This article aims to explore the impact of digital finance on the high-quality development of enterprises. By analyzing data from Chinese listed companies from 2010 to 2019 and using a multi time point double difference method, the article quantitatively evaluates the role of digital finance in alleviating financing constraints, enhancing environmental capabilities, and improving management efficiency for the first time. The research results indicate that the popularization and development of digital finance have significantly improved the environmental, social, and governance (ESG) performance of enterprises, especially in eastern China, low pollution industries, state-owned enterprises, and enterprises with low commercial credit supply. This article not only provides important empirical evidence for enterprises and governments, but also puts forward specific policy recommendations for deepening the application of digital finance and promoting high-quality development of enterprises.
An Analytical Approach to Understanding the Principles of Cryptography within the kaṭapayadi System as Reflected in the Works of Nemicandra
Authors:   Ph.D. Student, Department of Chinese Language, Sanchi University of Buddhist-Indic Studies, Sanchi, Dhakna Chapna, (Madhya Pradesh), India., Jadhav Prajna
Published: November 2024

The kaṭapayadi system is an alphabetic system of numeral notation developed in India. This paper aims to understand the ideas related to cryptography within the katapayadi system, although this system was not developed to hide information. To do this, this paper studies the use of this system in the Gommatasara Jivakaṇḍa and Trilokasaara of Nemicandra (981 CE) using an analytical approach. This paper finds that, like the Caesar cipher and Vigenere cipher, the ciphertext in this system is also a substitution cypher, but unlike them, the letters of the Sanskrit alphabet substitute the digits of a number in it with no shift. This system provides multiple ways to encrypt a number. It has symmetric encryption. Correctness property is ensured in it. In it, the writer is the one who encrypts the number into ciphertext, and the one who decrypts the ciphertext into a number is the reader. The key in this system was not a public key, although it was publicly available.
Contribution of Simplicity of Prepaid LUKU Meter Billing System on Property Tax Revenue Collection in Moshi Municipality, Tanzania
Authors:   Department of Domestic Revenue, Mwenge Catholic University, Moshi (Tanzania), East Africa., Mwanjala Grace J. , Mayala Dr. Nyanjige ,   Department of Economics and Business Studies (DEBS), Mwenge Catholic University (MWECAU), Moshi (Tanzania), East Africa., Komba Dr. Ladis ,   Department of Economics and Business Studies (DEBS), Mwenge Catholic University (MWECAU), Moshi (Tanzania), East Africa.
Published: November 2024

The simplicity of electronic systems, including prepaid billing systems, has been said to simplify life for clients and service providers. The Tanzania Revenue Authority (TRA) collects property tax through the Lipa Umeme Kadili Utumiavyo (LUKU) prepaid electricity billing system. This study sought to establish the influence of the systems simplicity on property revenue collection by TRA in Moshi Municipality. A concurrent research design with a mixed research approach was employed. The study was informed by the ability to pay principal theory. The study population was 14,364 premises installed with LUKU meters in the study area. A sample size of 192, determined by Fisher (1991), was used. A questionnaire was used to collect primary. Secondary data was obtained using a documentary review guide to gather data from audited reports of TRA from the financial year 2018/2019 to 2022 Slash 2023 (5 years). Content validity was used to ensure the instruments validity, while reliability was ensured through testre test measures. A statistical package for social science (SPSS) was used as an aid for data analysis where the regression models were run. The study anticipated an observable relationship between the simplicity of the LUKU system and property tax collection (independent and dependent variables), respectively. The study established that the simplicity of the LUKU system contributes to property tax collection in the study area at p value Less Then 0.05. The study concluded that the simplicity of use of the LUKU prepaid billing system has increased property tax revenue collection for TRA. It is recommended that TANESCO convert more meters into prepaid, as it will enhance property tax revenue collection capabilities and, at the same time, reduce costs associated with collection.