bluuebunny/crossref_metadata_2025 huggingface dataset:
Tercüme Eserlerde Dipnot Verilirken Verilen Dipnot İle Adres Gösterilen Temel Kaynağın Uyuşması Meselesi (Hayri Kırbaşoğlu Hadis Müdafaası Örneği)
Authors: PALABIYIK Abdülkadir
Published: December 2022

Dipnotlar verilerek yapılan akademik ve bilimsel çalışmalarda verilen bilgilerle dipnot olarak gösterilen adresteki bilgilerin tutarlılığı aynı zamanda yapılan ilmi çalışmaya güveni de artırır. Özellikle aynen alıntılarda bu tutarlılık daha da önem arz eder. Bunun yanında karşılaştırma, telmih, tahkiye etme, özet olarak sunma vb. dipnot şekilleri de olabilir. Bu durumlarda ise alıntı ile dipnot arasındaki ilişki ve irtibatın nasıl olduğunu belirten bakınız (bkz), karşılaştırınız (krş.), benzer rivayetler için bakınız gibi kısaltmalar veya açıklayıcı cümleler verilmelidir. Eğer böyle bir durum yoksa dipnotlar genellikle aynen alıntı gibi anlaşılır.

İbn Kuteybe’nin “Te’vilü Muhtelifi’l-Hadis” adlı kitabını ve Hayri Kırbaşoğlu tarafından yapılan “Hadis Müdafaası” isimli tercümesini dipnot-referans kaynak ilişkisi ve tutarlılığı açısından inceledik. Te’vil’in Arapçasında ayetlerin yerleri gösterilmiş fakat “hadislerin tahrici” yapılmamıştır. Buna karşılık Kırbaşoğlu tercümede “hadislerin tahrici”ni de vermiştir. Biz de bu tahriçlerden hareketle tercümenin Te’vil’deki Arapçası ve dipnotlarda verilen temel hadis kaynaklarından sadece veya birinci kaynak olarak verilen Buhari’nin Sahih’indeki yerlerini bulup karşılaştırmaya çalıştık.

Yaptığımız karşılaştırma sonucu özellikle dipnotlarda kaynak olarak gösterilen yerde olmayan hadisler, eksik olanlar, konu farklılığı olanlar ve Te’vilin ana metni ve tercümesinde bahsedilen konu ile alakası olmayan hadislerin var olması özellikle dikkat çekmektedir..
Model Sistem Verifikasi Dokumen Ijazah Digital Berbasis Teknologi Blockchain
Authors: Alfina Alfina , Syafrinal Syafrinal
Published: December 2022

Blockchain adalah sistem pencatatan informasi serta tidak dapat untuk mengubah, meretas, atau menipu. Seiring dengan perkembangan tentang teknologi baru, peneliti mengharapkan teknologi blockchain memiliki dampak yang sama pada dunia pendidikan khususnya di Perguruan Tinggi di Indonesia. Diharapkan dari hasil penelitian ini, adanya suatu model sistem verifikasi ijazah berbasis teknologi blockchain. Dari permasalahan di atas, maka diperlukan membuat suatu prototipe yang dapat melihat atau mendeteksi keaslian suatu dokumen khususnya ijazah pada perguruan tinggi di Indonesia. yaitu dengan menerapkan teknologi blockchain sebagai inovasi terbaru bagi masa depan Sistem Verifikasi Dokumen Ijazah Digital di Indonesia dan Dunia. Tujuan khusus penelitian antara lain untuk; 1) Merancang piranti berbasis visi komputer untuk menentukan identifikasi keaslian dokumen Ijazah, 2) Mengembangkan prototipe dan menguji fungsional pemrograman untuk mengetahui tingkat kesesuaian dengan kondisi lapangan, 3) Menerapkan teknologi blockchain dan sejenis untuk identifikasi Ijazah agar dapat mempercepat identifikasian ijazah. Alur penelitian dimulai menginput citra utama ijazah STMIK Indonesia Banda Aceh, kemudian diuraikan dalam format BlokChain sebanyak lima rantai, dimana setiap rantai diuji menggunakan metode Peak Signal to Noise Ratio (PSNR) dan nilai tertinggi merupakan citra yang identik. Hasil penelitian ini menunjukkan bahwa menggunakan format Block Chain dan metode PSNR adalah ditemukan citra yang identik.
The Door Activity Method on Writing Skills for Grade 4 Students at Madrasah Ibtidaiyah
Authors: Munfatiroh Siti , Ruroh Ermawati Zulikhatin
Published: December 2022

The research aims to determine the effect of relay writing method on student out door activity of description in the 4th grade at MI Al-Masyithoh Surabaya. The research used pre­-experimental design one group pre-test post-test. The population of the research was the student of 4th grade at MI Al-Masyithoh Surabaya which consist of 21 students. The sampling technique used in this research was saturated sampling. The sample of this research was the whole students in the 4th grade at MI Al-Masyithoh Surabaya. The instruments of this research were pre-test post-test. From the research results showed that the lowest score of pre-test was 45 and the highest was 80, and the mean score was 65,23%. While the lowest score of post-test was 70 and the highest was 95 and the mean score was 82,85%. It can be concluded that there is an effect of out door activity method on students description in the 4th grade at MI Al-Masyithoh Surabaya.
Implementation of Dakwah in the Era of Disruption
Authors: Ningrum Millati Eka Setia , Astutik Anita Puji
Published: December 2022

In its development, advanced technology is influenced in terms of economic, political, cultural, artistic and educational aspects. Internet is a medium that develops at a very high speed in this global technology era. There has been a shift from face-to-face sermons to sermons delivered by digital technology in recent years. The purpose of the research is to find out the implementation of da'wah in the era of disruption and to find out what factors cause the success and failure of digital da'wah media in the era of disruption. The method used is descriptive with a qualitative approach. The results of the study show that the implementation of Da'wah in the Era of Disruption in general, aspects of Islamic da'wah teachings consisting of aqidah, shari'ah, muamalah and morals have been widely taught. Then the success and failure factors of digital da'wah media in the era of disruption. The success factor of digital da'wah media in the era of disruption is internet users. While the failure factor is the emergence of increasingly complex problems in society.
Factor Analysis of Students Difficulty in Early Reading at Elementary School
Authors: Arifianto Teguh , Supriyadi Supriyadi
Published: December 2022

This study aims to analyze the factors that influence students' difficulty in reading the beginning by taking the object of research at Suko 1 Sidoarjo State Elementary School. While the type of research selected is a case study with 2 subjects. Data was collected through observation, interview, and documentation techniques. Then analyzed using the interactive analysis of the Miles model, namely data condensation, data presentation, drawing conclusions, and data verification. Test the validity of the data using triangulation techniques. The results showed that early reading difficulties were related to omitting words, replacing words, letters, stammering spelling, pronouncing wrong words, and pronouncing patent letters. These difficulties are influenced by four internal factors, namely daily activities, understanding of the material, psychological conditions, and learning motivation. External factors that affect learning difficulties in early reading are the role of the teacher and the family environment.
Increasing Ability to Recognize Letters Through Animation Media in Children Aged 5-6 Years in Kindergarten
Authors: Ayunda Ervina Nela , Aulina Choirun Nisak
Published: December 2022

The ability to recognize letters is the first step for children to be able to read, the ability to recognize letters well then the child tends to have the ability to read well too. This research is a classroom action research, with the object of Group B TK Dharma Wanita Persatuan Plaosan totaling 12 children. The writing of this study aims to determine the ability to recognize letters and the results of their improvement. Data collection techniques were carried out by means of observation, interviews and documentation. This research was conducted in 3 cycles, namely pre-cycle, cycle I and cycle II. Based on the results of the research that has been done, it can be seen that with animation media, the ability to recognize letters in children can be improved well with a significant increase in each cycle. The percentage value obtained in the first cycle reached a percentage of 56.5% but had not reached the success target, therefore it was carried out again in the second cycle which achieved a success percentage of 82.2%. Thus, it can be concluded that there is an increase in the ability to recognize letters through animation media in Dharma Wanita Persatuan Plaosan Kindergarten with a percentage reaching 82.2%.
Physical Education of Students in Higher Education Institution on the Basis of Volleyball
Authors: Abduvakhit Akhatovich Karimov  , Abdusamad Akhatovich Karimov
Published: December 2022

The article talks about the problems of increasing the efficiency of teaching students the technique of volleyball in the process of physical education. The severity of this problem is even more intensified if we take into account that volleyball is distinguished by a wide variety of techniques, and the time allocated for its study in the process of physical education at a university is limited.
Effect of Product Quality, Promotion, Brand Image on Sales Increase
Authors: Royani Mochamad Allim Uddin Rizal , Prapanca Detak
Published: December 2022

This study aims to determine that product quality, promotion, and brand image have a simultaneous effect on increasing sales. The Covid-19 pandemic has had a huge impact on Indonesia, especially in the economic sector. Not only in the economic sector, but the Covid-19 pandemic has an impact on the education and office sectors of this country. In this study using quantitative methods. Meanwhile, the data analysis technique used in this research is data quality test, classical assumption test, and multiple linear regression analysis.
The Influence of Taxation System Fairness, Financial Condition and Subjective Beliefs on Tax Compliance by Corporate Taxpayers with Intentions to Behave Obediently as Intervening Variables
Authors: Alam Ornela Aprillia , Ernandi Herman
Published: December 2022

This study aims to determine the effect of the fairness of the taxation system, financial condition and subjective beliefs on tax compliance by corporate taxpayers with the intention of obedient behavior as an intervening variable. The sampling technique used saturated sampling by distributing questionnaires, so that 38 respondents were obtained. The data analysis technique used is the Outer Model to test the validity and reliability. Next is the Inner Model to test the hypothesis by using the SmartPLS version 3.0 program tool. The results of this study indicate that the fairness of the taxation system has a significant effect on tax compliance by corporate taxpayers while for financial conditions, subjective beliefs and intentions to behave obediently do not have a significant effect, then the fairness of the taxation system, financial condition and subjective beliefs do not significantly affect tax compliance by corporate taxpayers with intention to behave obediently as an intervening variable.
The Influence of Good Corporate Governance, Corporate Social Responsibility, and Intellectual Capital on Financial Performance in Plantation Sub-Sector Manufacturing Companies Listed on the Indonesia Stock Exchange in 2019-2020
Authors: Iktiasari Firra Mayang , Setiyono Wisnu Panggah
Published: December 2022

The strategy carried out by the company must have strong competitiveness in national and international markets. One of the important goals of establishing a company is to increase the welfare of its owners or shareholders, or maximize shareholder wealth through increasing the value of the company. This study uses a quantitative method, the sample was selected by the purposive sampling method, namely 10 manufacturing companies in the plantation sub-sector, which are listed on the IDX for the 2019-2020 period. The data collection technique uses the company's annual report from the 2019-2020 period. The analytical technique used in this study is path analysis with the help of the Eviews 8 program. The results of this study indicate that Good Corporate Governance has a value of 0.04 < 0.05, Corporate Social Responsibility 0.29 < 0.05, and Intellectual Capital 0.46 < 0.05, which means the variable Good Corporate Governance , Corporate Social Responsibility, and Intellectual Capital have a very significant effect on the performance of manufacturing companies in the plantation sub-sector.
The Influence of Intellectual Capital on Firm Value with Financial Performance as an Intervening Variable in High-Ic . Companies
Authors: Amalia Anggun , Hermawan Sigit
Published: December 2022

This study aims to determine the effect of intellectual capital on firm value with financial performance as an intervening variable. The variables used in this study are Intellectual Capital (X1) as measured by VAIC, Firm Value (Y) as measured by Tobins Q and Financial Performance (Z) as measured by ROE. This research includes   associative   quantitative   research.   The data in   this study is secondary data. The population in this study are Healthcare Industry companiesxlisted on thexStock Exchange inx2014-2019. The samplingxtechnique used was purposivexsampling. The analytical technique usedxin this studyxuses the Partial LeastxSquare (PLS) technique. The resultsxin this study show that IC has an effect on the Financial Performance of Healthcare Industry companies. IC affects the value of pharmaceutical companies in the Healthcare Industry. Financial Performance has no effect on the Healthcare Industry Company Value. Financial Performance can not mediate the relationship between IC and Healthcare Industry Company Value.
The Effect of Dividend Policy on Financial Performance with Capital Structure as an Intervening Variable
Authors: Putra Herdyansyah Falendra , Fitriyah Hadiah
Published: December 2022

This study aims to determine the effect of dividend policy on financial performance with capital structure as an intervening variable. This study uses quantitative methods with secondary data as a data source. In this study the population data used are all pharmaceutical companies listed on the Indonesia Stock Exchange. The observation period was from the 2016-2020 period. In this study, non-probability sampling technique used in this study is purposive sampling. There are 8 pharmaceutical companies used as samples in this study. The data analysis technique used in this research is Structural Equation Modeling Partial Least Square (SEM-PLS). The results of this study indicate that Dividend Policy Affects Financial Performance. Dividend Policy Affects Capital Structure. Capital Structure Affects Financial Performance. Capital Structure Mediates the Effect of Dividend Policy on Financial Performance
The Role of Accounting and Household Financial Planning as Future Investment Efforts in an Islamic Perspective
Authors: Tyas Winda Sukmaning , Abidin Fityan Izza Noor
Published: December 2022

This study was conducted with the aim of knowing how the role of accounting and household financial planning as a future investment effort in an Islamic perspective on families in Beji village, Beji district, Pasuruan district. This research is a type of descriptive qualitative research. Data collection is done by interview, observation, and documentation. Informants in this study consisted of housewives who also worked (by profession), housewives who did not work (not by profession), and lecturers of Al-Islam and Kemuhammadiyahan Umsida. Based on the results of the study, (1) Housewives who became the object of this study had implemented the role of simple accounting in the household as a future investment effort in an Islamic perspective, the informants applied it with self-awareness and was very flexible. In other words, the housewives in this study practiced simple accounting according to their abilities and needs, without any binding stipulations or regulations. (2) Household financial planning has an important role as a future investment effort in the Islamic perspective. Good household financial planning and in accordance with the corridors of Islam is one way to prosper family life in the world and benefit in the hereafter. A prosperous and well-maintained world life will participate in maintaining maqashid sharia in human life, so that humans can easily realize benefits in their lives.
Analysis of Accounting Information Systems in Supporting Internal Control of People's Business Credit (KUR)
Authors: Putra Icksa Abdi , Maryanti Eny
Published: December 2022

A proper business is a business carried out by prospective debtors that can be profitable so that prospective debtors are able to pay interest and can repay all debts/credit principal obligations within the time agreed upon between the executing bank and the debtor. While what is meant by not yet bankable is MSME-K that has not met the financing requirements of the implementing bank in providing collateral or it can be said that it has not been able to meet the financing requirements in accordance with the provisions of the implementing bank. This research uses qualitative methods, according to Sugiyono (2011) qualitative research methods is a research method based on post-positivism philosophy, used to examine the condition of natural objects, (as opposed to experimentation) where the researcher is the key instrument, the sampling of data sources is carried out purposively and snowball, the collection technique is tri-angulation (combined). , data analysis is inductive or qualitative, and qualitative research results emphasize meaning rather than generalization. Based on the above analysis in terms of the credit assessment used in granting credit decisions. So it can be concluded as follows: Implementation of the Accounting Information System and internal control in the provision of People's Business Loans to the Limited Liability Company of Bank BRI Jabon unit which includes the Control Environment Component, Risk Assessment Component, Control Activity Component, Information and Communication Component, Monitoring / Supervision Component. according to COSO
Lifestyle Modification and medication use among Diabetes Mellitus Patients Attending Jimma University Medical Center, Jimma Zone, South West Ethiopia
Authors: Garedow Aster Wakjira , Jemaneh Tsiyon Mekoya , Hailemariam Addisalem Gebresilase , Tesfaye Gorfineh Teshome
Published: December 2022

Background: Diabetes, a non-communicable metabolic disease, causes multiple complications and deaths worldwide. It is a complex, chronic disease that requires continuous medical care with multifactorial risk reduction strategies beyond glycemic control. Ongoing patient education and
Self-management support are critical for preventing acute complications and reducing the risk of long-term complications. There is ample evidence that healthy lifestyle choices, such as a healthy diet, moderate weight loss, and regular exercise, can maintain normal blood sugar levels and minimize diabetes-related complications. In addition, this lifestyle change has a major impact on controlling hyperglycemia and can help to maintain normal blood sugar levels.
Objective: This study aimed to assess lifestyle modification and medication use in patients with diabetes mellitus at Jimma University medical center.
Methodology: Hospital-based prospective cross-sectional study was conducted to assess medication use and lifestyle modifications at Jimma University medical center. Data were checked for completeness, then entered into Epidata version 4.2 software and exported to SPSS version 21.0. Pearson’s chi-square test was performed to determine the association between KAP and independent factors. Variables with a p value <0.05 were considered significant.
Result: A total of 190 participants took part in this study with a response rate of 100%. In this study, 69(36.3%) participants had good knowledge, 82(43.2%) moderate knowledge and 39(20.5%) poor knowledge, 153(85.8%) had positive attitudes, 141 (74.2%) had good practice. Marital status, Occupational status and educational status were significantly associated with knowledge and attitude towards LSM and medication use. Marital status was the only variable that remained significantly associated with knowledge, attitude and practice towards LSM and medication use. Occupation, education, and marital status were significantly associated with knowledge and attitude towards LSM and medication use
Conclusion: The result of this study showed that more than 20% of the participants had poor knowledge, attitude, and practice towards medication use and LSM.Marital status was the only variable which remained to be significantly associated with KAP towards LSM and medication use
Improvised Dynamic Round-Robin Scheduling for Optimum Resource Utilization in Cloud Systems
Authors: Aradhya Suvarna N , Priya Rashmi
Published: December 2022

Task Scheduling is the process of assigning the incoming tasks to the available systems for optimum utilization of resources (CPU, Memory, Bandwidth, etc.). Optimum, in the present context implies executing maximum number of tasks using minimum of resources. In large scale Cloud Computing, resource optimization plays a critical role as it determines the quality of service (QoS) offered to customers. Therefore, task scheduling algorithm for parallel processing directly relates to QoS and is fundamental to understanding Resource Utilization, Inter-Process Communication, Network Latency, Load Balancing, Job Migration and Fault Tolerance. In this paper, an effort is made to explore and understand some of the basic scheduling algorithms through an experimental study. Algorithms are implemented in a cloud scenario. The results are construed with respect to several performance indicators that affect the QoS.
Use PROMs adapted for children and avoid PROMs developed for adults. Translation and Validation of paediatric IKDC subjective knee form in Lithuanian Children and Adolescents with Knee Disorders
Authors: Martinkeniene Viktorija Brogaite , Šaikus Andrius , Austys Donatas , Brazaitis Andrius , Bernotavičius Giedrius
Published: December 2022

Background/Purpose: The usage of children adapted PROMs is encouraged. This study is designed to translate and adapt the Pedi-IKDC for Lithuanian children with knee disorders and evaluate the psychometric properties of the new Pedi-IKDC version.
Methods: The translation process was performed under international guidelines. Patients aged 11-17 years with various knee disorders participated at three surveys and completed the Pedi-IKDC, Lysholm and PedsQL questionnaires. The internal consistency and reproducibility were determined by Cronbach alpha (a) statistics and intraclass correlation coefficient (ICC) respectively. For evaluation of reliability the standard error of measurement (SEM) and the smallest detectable change (SDC) were estimated. Regarding criterion validity, the Pearson correlations were assessed between Pedi-IKDC and Lysholm, PedsQL scores. The responsiveness to change was checked by calculating the effect size (ES) and standardized response mean (SRM). The floor and ceiling effects were verified for content validity.
Results: The Cronbach alpha (a) was 0.91 for overall score, 0.75 for symptoms and 0.92 for sport/function component of the score. The ICC for overall scores was 0.98 and from 0.87 to 0.98 for separate questions. SEM was 2.97 and SDC – 8.23. Moderate correlations (0.8> r > 0.5) were found to Lysholm and PedsQL physical functioning domain score, weak (0.5>r > 0.2) - to overall PedsQL score. Floor and ceiling effects were - 3,3%, and 1,6% respectively. The ES was 1,98 and SRM- 1,72.
Conclusions: The Lithuanian Pedi-IKDC version is suitable measurement tool to assess outcomes within paediatric population with different knee disorders. All the psychometric properties demonstrated acceptable results.
An Analytical Study of the Flow and Heat Transfer of Viscoelastic Fluid Between Two Wavy Walls Situated Symmetrically About a Mid Plane
Authors: Sahoo A. C.
Published: December 2022

In this work the two dimensional flow and heat transfer of a Visco-elastic fluid flowing steadily between two walls having periodic deformation and situated symmetrically about a mid plane is studied. The equation of motion and energy are solved with the help of the perturbation method taking the deformation of the boundaries small. Energy equation is solved under two types of thermal boundary conditions; (i) both walls are maintained at the same constant temperature and (ii) one wall is at constant temperature while the other wall is thermally insulated. The effects of visco-elastic parameter ‘K’ on the velocity distribution has been studied by draining the streamlines. We also note that the temperature distribution is not affected the presence of viscoelasticity of the liquid.
Prognostic predictors of radical resection of stage I-IIIB non-small cell lung cancer: the role of preoperative CT texture features, conventional imaging features, and clinical features
Authors: Zheng Xingxing , Li Rui , Fan Lihua , Ge Yaqiong , Li Wei , Feng Feng
Published: December 2022

Background
To investigate the value of preoperative computed tomography (CT) texture features, routine imaging features, and clinical features in the prognosis of non-small cell lung cancer (NSCLC) after radical resection.
Methods
Demographic parameters and clinically features were analyzed in 107 patients with stage I-IIIB NSCLC, while 73 of these patients received CT scanning and radiomic characteristics for prognosis assessment. Texture analysis features include histogram, gray size area matrix and gray co-occurrence matrix features. The clinical risk features were identified using univariate and multivariate logistic analyses. By incorporating the radiomics score (Rad-score) and clinical risk features with multivariate cox regression, a combined nomogram was built. The nomogram performance was assessed by its calibration, clinical usefulness and Harrell’s concordance index (C-index). The 5-year OS between the dichotomized subgroups was compared using Kaplan-Meier (KM) analysis and the log-rank test.
Results
Consisting of 4 selected features, the radiomics signature showed a favorable discriminative performance for prognosis, with an AUC of 0.91 (95% CI: 0.84 ~ 0.97). The nomogram, consisting of the radiomics signature, N stage, and tumor size, showed good calibration. The nomogram also exhibited prognostic ability with a C-index of 0.91 (95% CI, 0.86–0.95) for OS. The decision curve analysis indicated that the nomogram was clinically useful. According to the KM survival curves, the low-risk group had higher 5-year survival rate compared to high-risk.
Conclusion
The as developed nomogram, combining with preoperative radiomics evidence, N stage, and tumor size, has potential to preoperatively predict the prognosis of NSCLC with a high accuracy and could assist to treatment for the NSCLC patients in the clinic.
The Effects of a Health Education Curriculum on the Knowledge, Attitudes, and Practices of Primary School Students in Beijing, China toward Health-Related Themes: A Cluster Randomised Control Trial
Authors: Long Xin , Ji Ying , Zhang Hongwei , Zhang Xianan , Xie Lijing
Published: December 2022

Background: Most primary school students in China tend to show low health literacy and low adherence levels to healthy behaviors. Health education based on school has been shown to be effective in past studies, but separate health education curricula are rarely used in Chinese schools. This study evaluates the effects of a school-based health education curriculum on students’ knowledge, attitudes, and practices (or behaviors) (KAP) toward health.
Methods: This study uses a cluster randomised controlled trail. Four primary schools were selected and randomly assigned into a control group (n=165) and intervention group (n=262). A one-semester Health Education Curriculum System (HECS) for senior grade pupils was implemented in the intervention group, and the control group was only given a 1-hour health education lecture. The evaluation was assessed from baseline, post-intervention, and 1 year after intervention by changes in students’ KAP on oral health, screen time, physical activity, and other lifestyle choices. Data were collected through questionnaires and analyzed with SPSS 20.0 using Chi-square and ACNOVA.
Results: We found that the knowledge score increased immediately after intervention with a slight decrease in the follow-up stage, significant adjusted changes (95% CI) between the intervention and control groups in score was 5.83 (5.31 to 6.36) at post intervention and 2.59 (2.04 to 3.14) in 1 year follow-up. The prevalence of health-related behaviors were also enhanced to various extents from 13% to 38% between baseline and the post education stage in the intervention group (P<0.05), and pupils showed higher adherence to health choices than the control group at post-intervention and follow-up (P<0.05).
Conclusion:The current study shows that the health education curriculum can have positive effects on improving primary school students’ health KAP.
Trial registration: The study registered with the Medical Ethics Board of Capital Medical University (Z2019SY063) on October 2019. And retrospectively registered in Chinese clinical trial registry on 07/12/2022 (ChiCTR2200066506).
Point Prevalence Surveys of Antibiotic Prescribing in Children at a Tertiary Hospital in a resource constraint, low- income sub-Saharan African country.
Authors: AKINTAN PATRICIA , Oshun Philip , Osuagwu Chioma , Ola-Bello Olafoyekemi , Fajolu Iretiola , Roberts Alero , Temiye Edamisan , Oyinlola Oduyebo
Published: December 2022

Background Antibiotic resistance has been widely described in children by various pathogens to multiple antibiotics, these have become a global health crisis and an emergency. Factors associated with antibiotic use are both community and hospital based as studies have reported increased use of antibiotics by parents and caregivers as well as health care providers This study aimed to describe prevalence rates of antibiotic prescribing and evaluate antibiotic prescribing practices as well as targets for improving the quality of antimicrobial prescribing in children over time. Method Point prevalence survey of antimicrobial use was performed yearly for 4 years to monitor trends in antimicrobial prescribing., Data from all patients admitted before 8 am on the day of the PPS were included. A web-based application designed by the University of Antwerp was used for data-entry, validation and analysis (http://www.global-pps.com). Results A total of 260 children including 90 (34.6%) neonates and 170 (65.4%) older children were admitted during the four surveys. Overall, 179 (68.8%) patients received at least one antibiotic. In neonates, the prevalence of antibiotic use increased from 78.9–89.5% but reduced from 100–58.8% in older children. There was a reduction in the use of antibiotics for prophylaxis from 45.7–24.6%. The most frequently prescribed antibiotic groups were third generation cephalosporins and aminoglycosides. The most common indication for antibiotic prescribing was sepsis in neonates and central nervous system infection in older children. The documentation of reason in notes increased from 33–100% while stop review date also increased from 19.4–82.1%. Conclusion The prevalence of antibiotic use was high with cephalosporins being the most prescribed antibiotic.
Distinct neuronal populations mediate parenting and infanticide in the amygdalohippocampal area
Authors: Sato Keiichiro , Okuno Hiroyuki , Kitamura Kazune , Bito Haruhiko , Suzuki Yutaka , Minami Masabumi , Amano Taiju
Published: December 2022

Male animals exhibit positive and negative infant-directed behaviors, yet the underlying neural mechanisms remain unknown. The amygdalohippocampal area (AHi) regulates social behavior through neural projections to multiple brain regions. Although AHi neurons that project to the medial preoptic area (MPOA) were reported to promote infanticide in male mice, MPOA-projecting AHi neurons are activated by both parenting and infanticide, suggesting heterogeneity within these neurons. Here using a newly developed, virus-mediated projection-specific and activity-dependent cell labeling method (vPAL), we uncovered two distinct functional, electrophysiological, and transcriptional populations in MPOA-projecting AHi neurons, designated infanticide-related and parenting-related neurons. Furthermore, activation of serotonin receptor 7, which is highly expressed in parenting neurons, selectively suppressed infanticide while promoting parenting in virgin male mice. This study provides a better understanding of the neuronal populations, functions, and properties that previous labeling methods masked.
The impact of the two-year Covid-19 pandemic on hospital readmissions to a child and adolescent neuropsychiatric unit
Authors: Raffagnato Alessia , Miscioscia Marina , Bruni Gaia , Col Lara Del , Traverso Annalisa , Tascini Benedetta , Rossaro Maria Paola , Zanato Silvia , Gatta Michela
Published: December 2022

Background
Since2020 Italy and the world have been facing the health emergency related to the COVID-19 pandemic. Increasing evidence supports the association between the COVID-19 pandemic and the worsening mental health conditions of children and adolescents, with increased accesses in Emergency Departments and hospitalizations for psychiatric problems. This paper aimed to (a) study the population of patients admitted to a Neuropsychiatric Hospital Unit of North Italy during the pandemic two-year period, throughout a comparison with the population of patients hospitalized in the previous two years, according to socio-demographic and clinical variables (b) analyse the hospital readmission phenomenon, which has apparently increased its frequency during the first pandemic year according to recent studies.
Methods
This is an observational retrospective cohort study about 375 hospitalised patients from February 2018 to March 2022 due to neuropsychiatric problems. Data wereanalysed through mean, standard deviation, percentages, t-tests, chi-squared test, Fischer’sand non-parametric Mann-Whitney U-test. The level of statistical significance was set at p ≤ 0.05.
Results
Risk factors for mental health disorders were similar between the two groups, except for the significantly increased use of electronic devices in the COVID-19 one. Patients suffering from eating disorders tripled over time. Hospital readmissions almost doubled between the pre-COVID-19 two-year period and the COVID-19 period: 75% of patients hospitalized three or more times in the last two years and 85.7% of the so called “revolving door “patients (with relapse within three months after discharge) both belonged to the COVID-19group. The comparison between the two groups of patients readmitted before and during the COVID-19 pandemic didn’t show any differences in terms of socio-demographic and clinical characteristics.
Conclusions
These results suggest the inadequacy of local neuropsychiatric services in managing the complexity of clinical situations and the necessity to implement prevention strategies and services.
Dose DIP control medical expenses and suit for China ：evidence from Guangzhou in China
Authors: zhang mengjun , Liu Jing , Chen Yunshan , Ma Luning , Wu Zhiming , Xiang Guochun
Published: December 2022

Background China's health spending has surged in the past five years, rising from 1,315.9 billion yuan to 1,754.5 billion yuan, an average annual growth rate is 7.5%. In order to control the excessive growth of medical expenses, China proposed Diagnosis-Intervention Packet (DIP) and DRGs payment methods based on local conditions, DIP was piloted in Guangzhou in 2018. The purpose of this study is to better provide evidence for the development of medical payment methods and also provide policy information for the development of medical insurance payment methods to support the promotion of DIP.
Methods The data were collected from the medical expenses of inpatients provided by the Medical Insurance Department of a tertiary hospital in Guangzhou. SPSS 26.0 software was used to calculate the average hospitalization cost (AHC), proportion of nursing expenses (PNE), proportion of medicines fees (PM), proportion of examination fees (PEF), proportion of laboratory fees (PLF), length of stay and average age of inpatients from four dimensions without distinguishing diseases, core diseases, comprehensive diseases and single diseases. The Difference in Difference (DID) model was used to empirically analyze the data, and the robustness was tested.
Results After the implementation of DIP, the growth rate of medical expenses has been controlled. As the cost data for all inpatients, compared with Fee-For-Service (FFS), DIP increased the PNE (β=0.006, p<0.1), and decreased PM(β=-0.051, p<0.05). From the perspective of core disease dimension, DIP decreased PEF (β=-0.015, p<0.05) and PM (β=-0.076, p<0.1). From the perspective of comprehensive diseases, DIP increased PNE (β=0.005, p<0.1). In terms of single diseases, DIP decreased the PEF (β=-0.044, p<0.05) and PLE (β=-0.054, p<0.001). The empirical results passed the equilibrium trend test and the robustness test.
Conclusions DIP is more suitable for China's medical environment. It controls the growth rate of medical service costs, reduces PM, PLF and PEF to varying degrees, changes the structure of medical costs, guides the rational allocation of medical and health resources, and reflects the value of medical personnel services.
Diabetes impairs fracture healing through Foxo1 mediated disruption of ciliogenesis
Authors: Chinipardaz Zahra , Yuan Gongsheng , Liu Min , Graves Dana , Yang Shuying
Published: December 2022

Foxo1 upregulation is linked to defective fracture healing under diabetic conditions. Our previous studies showed that diabetes impairs ciliogenesis resulting in defective fracture repair. However, the mechanism by which diabetes causes cilia loss during fracture healing remains elusive. We report here that streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) dramatically increased Foxo1 expression in femur fractured calluses, resulting in a significant decrease in the expression of IFT80 and primary cilia number. Ablation of Foxo1 in osteoblasts in-vivo (OSXcretTAFoxo1f/f) rescued IFT80 expression and restored ciliogenesis as well as restored bone formation and mechanical strength in diabetic fracture calluses. In-vitro, advanced glycation end products (AGEs) impaired cilia formation in osteoblasts and reduced the production of a mineralizing matrix, which were restored by Foxo1 deletion. Mechanistically, AGEs increased Foxo1 expression and transcriptional activity to inhibit the IFT80 expression causing impaired cilia formation. Thus, our findings demonstrated that diabetes impairs fracture healing through Foxo1 mediated inhibition of primary cilia formation, resulting in impaired osteogenesis. Inhibition of Foxo1 and/or restoration of cilia formation has the potential to promote diabetes-impaired fracture healing.
Immunoinformatics design of novel peptide vaccines against Epstein-Barr virus with over 99% global population coverage: A Reverse Vaccinology approach
Authors: Yousaf Hassan , Naz Anam
Published: December 2022

Background
Epstein-Barr virus is commonly known as human herpes virus 4; an oncovirus belonging to the herpes virus family. The pathogen is extremely ubiquitous and infects more than 90% of population once in a lifetime.
Methods
The current study has employed a computational pipeline to develop a multiepitope vaccine design by targeting the most antigenic glycoproteins of the virus. The proteins were separately processed to retrieve B-cell and T-cell epitopes. The most suitable epitopes were scrutinized to design the peptide vaccine using appropriate linkers and adjuvants. The designed chimeric vaccines were further analyzed for their molecular interactions with TLR-4 and CD21 receptor. Consequently, the structural motion of the docked complexes was analyzed by molecular dynamics simulation approach followed by immune simulation.
Results
Our results showed promising outcomes in terms of vaccine antigenicity, population coverage and significantly lower free binding energies with potential receptors tested on 4 different docking platforms.
Conclusion
The conducted in silico study concludes that peptide vaccines could be a suitable alternative to traditional vaccinology approaches. Hence, our study will aid in the better formulation of vaccines in future by targeting the suitable drug or vaccine candidates.
Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing
Authors: Shen Zhanlong , li yansen , Lin Yilin , Zhao Long , Yang Changjiang , Wang Bo , Gao Zhidong , Jiang Kewei , Ye Yingjiang , Wang Shan
Published: December 2022

Background: Gastric cancer is one of the most common malignant tumors worldwide. Patients with alpha fetoprotein (AFP)-positive gastric cancer (AFPP-GC) are considered a special group among gastric cancer cases. At present, there are still controversies about the clinicopathological characteristics and prognosis of AFP-GC, and the potential mechanism of its high malignant potential is still unclear. There is a lack of a comprehensive description of AFPP-GC genome characteristics and regulatory mechanisms.
Methods: This study analyzed the pathological characteristics and prognosis of AFPP-GC through clinical samples. The characteristics of AFP-positive gastric cancer were identified by cross-linking analysis between sequencing data and public databases. To verify the mechanism of AFP positive gastric cancer promoting gastric cancer metastasis.
Results: The results showed that the prognosis of AFPP-GC was poor, with a high risk of liver metastasis. Tissue transcriptome sequencing showed that AFPP-GC high-expression genes were involved in the activation of various cancer pathways, and low-expression genes were involved in the immune response. Single sample gene set enrichment analysis showed that overexpression of APF in AFPP-GC significantly inhibited the infiltration of CD8+ T cells. To further explore the genomic characteristics of AFPP-GC, the signaling pathway by whichAFP regulatesthe invasion and metastasis of AFPP-GC cells was discussed. The results showed that AFPP-GC may promote cell invasion by regulating thePTEN/ATK1/SOX5/CES1 signalingaxis. This study reveals the molecular mechanism by whichAFPP-GC has higher malignant potential than AFPN-GC. This finding provides an important strategy for the individualized treatment of AFPP-GC.
Soil Micromorphology for Modeling Spatial on Landslide Susceptibility Mapping
A Case Study in Kelara Subwatershed, Jeneponto Regency of South Sulawesi, Indonesia
Authors: Ahmad Asmita , Farida Meutia , Juita Nirmala , Jayadi Muh
Published: December 2022

Most of the results of classifying the level of susceptibility show different results, where landslides are more common in areas with a relatively high to moderate susceptibility class compared to those with a high susceptibility class. Differences in methods result in differences in the susceptibility maps resulting from the parameters that cause the tested landslides. The Spatial Regression Model can precisely interpret the relationship between several landslide parameters and events and shows better data accuracy than other methods. Utilization of soil micromorphological parameter data in mapping the level of susceptibility of the soil that triggers landslides with a Spatial Regression model so that the resulting susceptibility map can be more accurate. The soil parameter test method was carried out using a split-plot design with land use as the main plot, slope as a sub-plot, and soil physics (permeability, bulk density, and porosity) as a sub-sub-plot with three replications. Spatial modeling is done through regression analysis using ordinary least squares. The first test analysis was carried out with general parameters: lithology, rainfall, slope, land cover/land use, and population, while the second test was with parameters: lithology, rainfall, slope, land cover/land use, population, soil organic carbon, texture, erodibility and soil micromorphology. Classification of vulnerable classes using the natural breaks method. The interaction between the type of land use, slope, and physical properties of the soil on the occurrence of landslides at the study site shows a strong relationship with a significant p-value = 0.043 less than the α 5% level. Increased land use by the community has triggered the formation of soil micromorphology in the form of plane voids, cross-striated and grano-striated, which can trigger internal shifts (micro-shifts) in the soil body. The landslide susceptibility map at the study site is divided into seven spatial susceptibility classes: extremely low, very low, low, moderate, high, very high, and extremely high. Spatial modeling with OLS shows that the independent factors in the form of lithology, rainfall, slope, land cover/land use, and population only get an R2 value of 30.8%. Adding landslide independent parameter data in the form of soil organic carbon factor, texture, erodibility, and soil micromorphology produces a spatial model of landslide susceptibility with an increase in the accuracy value of R2 by 66.66%. The spatial model shows a high level of consistency with very significant soil micromorphology at a p-value < 0.01. The resulting spatial model is more accurate, where the high susceptibility class has a more significant number of landslide events, and landslides decrease according to the class.
Prevalence and Influence on Prognosis of Mental Health Comorbidities in Long-term Breast Cancer Survivors: Results From the Surbcan Study
Authors: Padilla-Ruiz María , Gimeno-Miguel Antonio , Rivas-Ruiz Francisco , Martínez-Casanova Mª Carmen , Jansana Anna , Prados-Torres Alexandra , Poblador-Plou Beatriz , Cura Isabel Del , Sanz-Cuesta Teresa , Ibáñez Berta , Castells Xavier , Sala María , Redondo Maximino
Published: December 2022

Aim
The increase in survival of patients with breast cancer has largely been due to early detection and treatment advances, which has led to longer follow-up and treatment of these patients. The principal aim of this work is to describe the presence of mental health comorbidities and analyze their influence on survival in women who are long-term breast cancer survivors.
Methods
This retrospective multicenter cohort study is part of the SURBCAN Study, a cohort of 4,088 women who are long-term breast cancer survivors diagnosed between 2000 and 2006 who were followed-up on between 2012 and 2016. A descriptive analysis of the study population’s characteristics and prevalence of mental health comorbidities was performed. A Cox regression analysis was performed to study the influence of mental health comorbidity on all-cause mortality.
Results
A total of 42.2% of patients presented with at least one mental health comorbidity, notable among which were anxiety disorders and depression and mood disorders, with a prevalence of 37.6% and 21.1%, respectively. The presence of a mental health comorbidity was associated with a poor prognosis (HR: 2.13; 95% CI: 1.70–2.66), as was more advanced tumor stages.
Conclusions
The presence of mental health comorbidities in women who are long-term breast cancer survivors is associated with lower survival. Individualized follow-up in which the patient’s mental health status is specifically monitored is recommended.