bluuebunny/crossref_metadata_2025 huggingface dataset:
Distance as Explanatory Factor for Sexual Health Centre Utilisation in an Infrastructure-Rich Urban Area in the Netherlands: A Population-Based Multilevel Study
Authors: Twisk Denise E. , Meima Bram , Nieboer Daan , Richardus Jan Hendrik , Götz Hannelore M.
Published: November 2020

BackgroundThe sole sexual health centre (SHC) in the greater Rotterdam area, the Netherlands, is instrumental in finding people unaware of their STI/HIV status. We hypothesized that travel distance to the SHC is inversely associated with SHC utilisation. Insight in area-specific utilisation is needed for potential new outreach policies to enhance STI testing. MethodsThe study population consists of all residents aged 15 to 45 years in the greater Rotterdam area (2015-2017). We linked SHC consultation data from STI tested heterosexual clients to the population registry. The association between SHC utilisation and distance was investigated by multilevel modelling, adjusting for sociodemographic and area-specific determinants. The data was also stratified by age (aged below 25) and migratory background (non-Western), since SHC triage may affect their utilisation. We used straight-line distance between the centroid of the postal code area and SHC address as a proxy for travel distance. ResultsWe found large area variation in SHC utilisation (ranged from 1.13 to 48.76 per 1,000 residents). Both individual and area level determinants determine utilisation. Travel distance explained most area variation and was inversely associated with SHC utilisation when adjusted for other sociodemographic and area-specific determinants (odds ratio [OR] per kilometre: 0.95; 95% CI: 0.93-0.96). Similar results were obtained for residents aged below 25 (OR: 0.95; 95% CI: 0.94-0.96), but not for non-Western residents (OR: 0.99; 95% CI: 0.99-1.00). ConclusionLiving further away from the sole SHC in the greater Rotterdam area decreases utilisation. This provides evidence for local policy to enhance STI testing, for example by offering STI testing services closer to the population.
Development of an Implementation Process Model: A Delphi Study
Authors: Parker Gillian , Kastner Monika , Born Karen , Berta Whitney
Published: November 2020

Background: There is general scarcity of research on key elements of implementation processes and the factors which impact implementation success. Implementation of healthcare interventions is a complex process. Tools to support implementation can facilitate this process and improve effectiveness of the interventions and clinical outcomes. Understanding the impact of implementation support tools is a critical aspect of this process. The objective of this study was to solicit knowledge and consensus from relevant implementation science and knowledge translation healthcare experts in order to refine and validate a process model of key elements in the implementation process.Methods: A two round consensus-based modiﬁed Delphi study involving international experts in knowledge translation and implementation (researchers, scientists, professors, decision-makers) was conducted. Participants rated and commented on all aspects of the process model, including the organization, content, scope, and structure. Delphi questions rated at 75% agreement or lower were reviewed and revised. Qualitative comments supported the restructuring and refinement. A second-round survey followed the same process as Round 1. Results: Fifty-four experts participated in Round 1, and 32 experts participated in Round 2. Twelve percent (n=6) of the Round 1 questions did not reach consensus. Key themes for revision and refinement were: stakeholder engagement throughout the process, iterative nature of the implementation process; importance of context; and importance of using guiding theories or frameworks. The process model was revised and refined based on the quantitative and qualitative data and reassessed by the experts in Round 2. Consensus was achieved on all items in Round 2 and the Delphi concluded. Additional feedback was obtained regarding terminology, target users and definition of the implementation process.Conclusions: High levels of agreement were attained for all sub-domains, elements, and sub-elements of the Implementation Process Model. This validated model will be used to develop an Implementation Support Tool to be used by healthcare providers to facilitate effective implementation and improved clinical outcomes.
Convergent Molecular Evolution of PEPC Gene Family in C4 and CAM Plants
Authors: Shu Jiang-Ping , Yan Yue-Hong , Wang Rui-Jiang
Published: November 2020

Background: Phosphoenolpyruvate carboxylase (PEPC), as the key enzyme in initial carbon fixation of C4 and crassulacean acid mechanism (CAM) pathways, was thought to undergo convergent adaptive changes resulted in the convergent evolution of C4 and CAM photosynthesis in vascular plants. However, the integral evolutionary history and convergence of PEPC in plants remained lack of understanding. Results: In present study, we identified the members of PEPC gene family across green plants with genomic data, found ten conserved motifs and modeled three-dimensional protein structures of 90 plant-type PEPC genes. After reconstructed PEPC gene family tree and reconciled with species tree, we found PEPC genes occurred 71 gene duplications and 16 gene losses, which might result from whole-genome duplication events in plants. Based on the integral phylogenetic tree of PEPC gene family, we detected four convergent evolution sites of PEPC in C4 species but no one in CAM species. Conclusions: PEPC gene family was ubiquitous and highly conservative in green plants. After originated from gene duplication of ancestral C3-PEPC, C4-PEPC isoforms underwent convergent molecular substitution that facilitated the convergent evolution of C4 photosynthesis in Angiosperms, but PEPC gene did not exist molecular convergence corresponded to the multiple independent evolution of CAM photosynthesis. Our findings help to understand the origin and evolution of C4 and CAM pathways and shed new light on the adaptation of plants in drought and high-temperature habitats.
Retinitis Pigmentosa Is Associated With Shifts in The Gut Microbiome
Authors: Kutsyr Oksana , Maestre-Carballa Lucía , Lluesma-Gomez Mónica , Martinez-Garcia Manuel , Cuenca Nicolás , Lax Pedro
Published: November 2020

Background: The gut microbiome is known to influence the pathogenesis and progression of neurodegenerative diseases. However, there has been relatively little focus upon the implications of the gut microbiome in retinal diseases such as retinitis pigmentosa (RP) that leads to photoreceptor degeneration and is the main worldwide cause of complete blindness in adulthood. Here, we investigated changes in gut microbiome composition linked to RP, by assessing both retinal degeneration and gut microbiome in the rd10 mouse model of RP as compared to control C57BL/6J mice.Results: In rd10 mice, retinal responsiveness to flashlight stimuli was deteriorated with respect to observed in age-matched control mice, with decreased amplitudes in the a- and b-wave responses of the electroretinogram and concomitant reduction of the visual acuity. This functional decline in dystrophic animals was accompanied by photoreceptor loss, evidenced by decreased outer nuclear layer thickness, and morphologic anomalies in photoreceptor cells. Changes in retinal neurons were paralleled to induction of reactive gliosis in retina, with increased microglial cell numbers and higher Müller cell reactivity in rd10 mice. Furthermore, 16S rRNA gene amplicon sequencing data showed a microbial gut dysbiosis with differences in alpha and beta diversity at the genera, species and amplicon sequence variants (ASV) levels between dystrophic and control mice. A taxonomic partitioning of ASV was observed since unique ASVs present in only one group had a cumulative relative microbial abundance between 17.6% (rd10 mice) and 26.7% (C57BL/6J mice). Remarkably, four fairly common ASV in healthy gut microbiome belonging to -Rikenella spp., Muribaculaceace spp., Prevotellaceae UCG-001 spp., and Bacilli spp.- were absent in the gut microbiome of retinal disease mice, while Bacteroides caecimuris was significantly enriched in mice with retinitis pigmentosa. Conclusions: Our results indicate that retinal degenerative changes in retinitis pigmentosa are linked to relevant gut microbiome changes. The findings suggest that microbiome shifting could be considered as potential biomarker and therapeutic target for retinal degenerative diseases.
Peptidome-Based Serotyping of The Food-Borne Pathogens Salmonella Enterica by Label-Free Mass Spectrometry
Authors: Wang Xixi , Yang Yang , Wang Lian , Li Ming , Zhang Peng , Liang Shufang
Published: November 2020

Background: Food-borne diseases caused by Salmonella enteric serovars represent a serious public health problem worldwide . More than 2500 different serovars have been reported to relate with food-borne diseases according to the classification of White-Kauffmann-Le Minor scheme by now. A quick identification for the pathogens is critical for controlling food pollution and disease spreading. Results: Here we applied a peptidomic analysis for quickly and precisely identifying serovar-specific peptide markers based on LC-MS/MS profiling of epidemiologically important Salmonella enterica subsp. enterica serovars in China. By label-free quantitative peptidomics MS identification, the 53 most variable serovar-related peptides were screened as potential peptide biomarkers, based on which a C5.0 predicted model with 4 predictor peptides was generated and a test set of 17 Salmonella enterica strains were classified with the accuracy of 94.12%. It is effective to determine the genotypic similarity among Salmonella enteric isolates according to each strain peptidome profiling, which is indicative of potential incidence even breakout of food contamination. This high-throughput strain peptidomic fingerprints are complementary to the genomic patterns by PFGE analysis for precise identification of 5 Salmonella enterica serovars including Enteritidis , Typhimurium , London, Rissen and Derby . The biological analysis showed that most of the changed peptides/proteins were enzymes related to nucleoside phosphate and energy metabolism. Conclusions: the LC-MS/MS based quantitative peptidomic dissection on Salmonella enteric serovars provides a novel insight and real-time monitoring of food-borne pathogens.
Neuroprotective Effects of Panax Notoginseng Saponins against Cerebral Ischemia via Improving Glutamate Metabolism Pathway: In Vivo and In Vitro
Authors: Qiao Yuan , Ma Qing , Li Ya , Fan Chunlan , Tang Minke
Published: November 2020

Background: Ischemic stroke patients suffer from relatively limited treatment options. Studies have shown that glutamate is the most important excitatory neurotransmitter in the central nervous system. However, excessive glutamate in the extracellular cause cell apoptosis, and neurodegenerative processed after cerebral ischemia stroke. Glutamate metabolism pathway is necessary for glutamate clearance after ischemic stroke. Here we investigated the in vivo and in vitro effects of Panax Notoginseng Saponins (PNS) on glutamate metabolism pathway. Methods: we used mice impaired by middle cerebral artery occlusion (MCAO) and astrocytes exposed to oxygen-glucose deprivation/ reoxygenation (OGD/R) to test the potential mechanism of PNS. In vivo, we determined the cerebral infarction volume and measured brain water content. In vitro, we measured the astrocytes viability and evaluated the morphology of astrocyte. In addition, glutamate uptake, Na+-K+-ATPase activity, the expression levels of glutamate transporter GLT-1 and glutamine synthetase (GS) were determined in vivo and in vitro. Results: In vivo, we demonstrated that PNS could significantly decrease cerebral ischemia injury and improve neurological function in mice impaired by MCAO. In vitro, we found that PNS increased astrocytes viability, inhibited LDH leakage, and improved morphology of astrocytes under OGD/R. Additionally, we reported that both in vivo and in vitro, PNS enhanced the glutamate uptake and Na+-K+-ATPase activity, and up-regulated the expression levels of glutamate transporter GLT-1 and GS. Conclusion: this study suggested that PNS protects against cerebral ischemia induced brain damage. The possible mechanism is related with inhibiting glutamate accumulation by improving glutamate metabolism pathway.
Magnitude of Medication Administration Error and Associated Factors Among Nurses Working in Madda Walabu University Goba Referral Hospital, Bale Zone Oromia Region, Southeast Ethiopia
Authors: Haile Hiwot Fikadu , Takele Abulie Melku , Abdi Addisu Gemechu
Published: November 2020

Background: Administration of medication is the primary responsibility of nurses. Medication errors occurring during the drug administration process can be attributed to a variety of safety effects, ranging from undetected errors to prolonged hospital stays, discomfort and death.Objective: To determine the magnitude of the medication administration error and associated factors among nurses working at Madda Walabu University Goba Referral Hospital, Bale Zone Oromia Region, South East Ethiopia.Methods: A facility-based cross-sectional study was conducted at Madda Walabu University Goba Referral Hospital Inpatient Department from February to March, 2020. The study included three hundred ninety-eight medication interventions administered by 89 inpatient unit working nurses during the study period. Data were collected using a pre-tested, structured questionnaire and drug administration assessment using a checklist. Data were analyzed using SPSS version 22 and Frequency , Percentage, Means and SD were analyzed for descriptive analysis. COR and AOR were calculated to see the association of independent variables and uncontrolled hypertension at 95% CI and p-value <0.05 was considered statistically significant.Result: The magnitude of the medication error was 248 (62.3%). The most common type of medication error was wrong documentary evidence (53.5% ) , followed by wrong time (39.2%) and wrong dosage (28.%). Variables that were substantially associated with medication administration error include work experience of nurses 0-4 years (AOR = 10.8, 95% CI (4.5-25.86), 5-9 years of service (AOR = 4.05, 95% CI (1.47-11.715), nurses 1-6 (AOR = 0.36, 95% CI (0.17-0.76) nurses 7-10 (AOR = 0.45, 95%CI (0.21-0.96) route IV of medication (AOR =0.13, 95 % CI (0.03 - 0.60) and IM route (AOR =.0.12, 95 % CI (0.02 -0.74) at p-value <0.05. Conclusion: Medication administration error was highly prevalent. Work experience, nurse to patient ratio and route of medication administration were statistically significant factors associated with occurrence of medication administration error. The preparation of nurses and the hospital staff profile would be helpful in minimizing mistakes in the administration of drugs.
Efficacy and Safety of Xuebijing Injection for Severe Pneumonia: A Protocol for A Systematic Review and Meta-Analysis
Authors: Zhang Mina , Feng Luda , Zhang Shuwen , Jiang Ping , Liang Ning , Huang Po , Xu Xiaolong , Liu Qingquan
Published: November 2020

Background: Severe pneumonia (SP) is a life-threatening condition without specific treatment options. Although there are many available treatment options for SP, most of the therapies have been associated with mild or severe side effects. The purpose of this meta-analysis is to examine the efficacy and safety of Xuebijing injection (XBJ), a Chinese patent approved by the China Food and Drug Administration, for treating patients with SP.Methods: An electronic and manual search of published articles, ongoing trials, dissertations, and grey literature will be performed. Electronic databases including Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Data, SinoMed will be searched without language restrictions from their inception to 01/10/2020. All randomized controlled trials where (a) XBJ is compared with placebo or no treatment, (b) XBJ plus routine treatment is compared with routine treatment, and (c) XBJ plus co-interventions are compared with co-interventions will be included. Severe pneumonia-related mortality will be set as the primary outcome. Study inclusion, data extraction, and quality assessment will be independently performed by two reviewers. Review Manager 5.3 is to be used to perform the assessment of the risk of bias, data synthesis, and subgroup analysis. Grading of Recommendations Assessment, Development, and Evaluation approach will be used to evaluate the quality of the overall evidence. This protocol was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols.Discussion: This proposed systematic review and meta-analysis will identify and synthesise evidence to clarify efficacy and safety of XBJ for SP. The results will help provide the best available evidence to decision-makers.PROSPERO registration number: CRD42020181234
Correlates of HIV Testing Frequency in MSM Based on a Survey from 2011-2018: A Hint for Risk Reduction Strategy
Authors: Liu Zhongquan , Chen Yang , Yao Tingting , Zhang Tiantian , Song Desheng , Liu Yuanyuan , Yu Maohe , Xu Jie , Li Zhijun , Yang Jie , Cui Zhuang , Li Changping , Ma Jun
Published: November 2020

Background:In recent years, HIV testing has become one of the effective strategies to reduce the risk of the disease. Frequent HIV testing can be cost effective. Therefore, an in-depth study of factors related to the testing behavior of men who have sex with men (MSM) were analyzed to optimize intervention strategies.Methods:From March 2011 to October 2018, the project was carried out in a Tianjin bathhouse, and 5165 MSM were surveyed using snowball sampling. Factors related to HIV testing behavior were analyzed by multi-level multiple logistic regression analysis after grouping according to testing frequency, and comprehensive analysis was performed.Results:The multivariate logistic analysis showed that 6 variables including young MSM(OR=0.67, 95% CI: 0.49-0.92, P=0.01), low-education MSM (OR=0.60, 95% CI: 0.47-0.76, P <0.0001), low AIDS knowledge (95% CI: 0.22-0.29, P <0.0001), marital status(OR = 1.30, 95% CI: 1.07-1.58, p = 0.007), acceptance of condom promotion and distribution(OR = 10.98, 95% CI: 8.33-14.47, p <0.0001), and frequency of condom use(p <0.05) could link to HIV testing behaviors.Conclusions:In order to achieve the 90-90-90 goal, targeted publicity and education and promote self-testing kit should be carried out to encourage frequent HIV testing, mainly including Young MSM (especially students), low-education people, married MSM and those who cannot keep using condoms during anal sex.
Investigation on Magnetorheological Finishing of thin Copper Substrate
Authors: Pan Bo , Kang Renke , Zhang Yunfei , Li Kailong , Du Dongxing , Guo Xiaoguang , Wang Bin , Wang Chao , Guo Jiang , Zhu Xianglong , Huang Wen
Published: November 2020

Thin copper substrates in precision physical experiments are commonly machined by double-sided lapping to obtain high flatness. However, the flatness is limited by the accuracy of lapping plate, process vibration and so on in double-sided lapping process. Hence, magnetorheological finishing (MRF) with its good performance on profile modification is employed to improve the flatness. Nevertheless, thin copper substrates, which are sensitive to the stress, deformed easily with uneven material removal on the surface. In this paper, MRF is conducted on machining thin copper substrate for the first time considering deformation induced by stress. A finite element model is established to evaluate the deformation by residual stress, and the results show that the deformation tends to be more serious with the increase of the material removal. According to the simulation results, the material removal is optimized considering both deformation and efficiency, and a series of experiments are conducted on a Φ100×2.8 mm workpiece to verify the simulation results. The experimental results show that the flatness is further improved from peak to valley (PV) 6.6 μm to PV 2.3 μm with optimized processing parameters. Hence, the feasibility of magnetorheological finishing on thin copper substrate is demonstrated.
PD-L1 Expression in Colorectal Carcinoma: Immunohistochemical Study
Authors: Gupta Mehak , Manjari Mridu , Kaur Harjot
Published: November 2020

Background : Colorectal carcinoma is the most common type of GIT malignancy which is a multifactorial process with etiology encompassing genetic factors, environmental exposures and inflammatory conditions of the digestive tract.

Method: 40 histologically proven cases of colorectal carcinoma were subjected for IHC expression of PD-L1 using Biocare kit. PD-L1 was taken positive as yellow to brown particles in membrane, cytoplasm or both. It was graded depending upon staining intensity and percentage of the cells and scoring was done by multiplying both and ≥ 3 was taken as positive score.

Result : Most of the cases were in 6th and 7th decade of life (62.5%) with M:F ratio being 1.4:1. Most common site involved was rectum. Histologically 29 cases were conventional adenocarcinoma with rest being mucinous and mucin secreting type and most of them being moderately differentiated (70%). On immunohistochemistry, PD-L1 expression was seen in 20 cases with moderate and strong intensity. But PD-L1 score was positive in 14 cases (35%). TIL was positive in 57.5% of the cases. Statistically there was significant correlation between histological type of tumor with PD-L1 (p value=0.03) and TIL (p value=0.017). Although PD-L1 positivity was insignificant with histological differentiation (p value=0.65) but TIL was significant (p value=0.03).

Conclusion : PD-L1 expression is relevant to the prognosis as well as for further CRC therapies whereas the TIL cell positivity has become an independent predictor of patients survival.
An Unusual Presentation of Idiopathic Multicentric Castleman Disease: The Great Masquerader
Authors: Mazumder Sujaya , Naidu Raji Tejas , Cherian Susan , Mayura Sruthi , Chaturvedi Uma Pankaj
Published: November 2020

Castleman disease is an uncommon, non-clonal, lymphoproliferative disorder characterized by lymphadenopathy and symptoms related to hypercytokinemia. Clinically it is classified as unicentric and multicentric disease. Multicentric disease is further subclassified as HHV- 8 associated disease and idiopathic disease, which is the rarest subtype. The incidence of idiopathic disease is estimated to be 5 per million person years. The diagnosis of Idiopathic Multicentric Castleman disease is complicated by an array of clinical mimics and non-specific symptoms. We report a rare case of Idiopathic Multicentric Castleman disease in a young female where a detailed pathological work up helped to secure the diagnosis and exclude its mimics.
Epstein Barr Virus in Hodgkin’s Lymphoma a Path Less Treaded: An Observational Study
Authors: Balhara Kirti , Singh Sarika , Jain Shyamlata , Daga M K , Vindal Anubhav
Published: November 2020

Background: Epstein-Barr virus (EBV) is a ubiquitous virus belonging to γ-Herpesvirus subfamily, infecting B cells, T cells, Natural killer (NK) cells & causes both benign and malignant diseases. It has been detected in large subset of Hodgkin lymphoma (HL) cases around the world, especially in countries with poor socioeconomic conditions and among younger age. Limited studies are available reflecting the Indian scenario of HL and EBV association. EBV positivity in Indian HL varies from 28-97% Majority of these studies employed Immunohistochemistry (IHC) for LMP1, a few performed In Situ Hybridisation (ISH) for EBER.

Objective: To study the association of EBV in classical HL by immunohistochemical expression of latent membrane protein 1 (LMP1) antigen in North Indian population and to correlate it with different demographic variables & subtypes of HL.

Materials and Methods: Observational study including 26 untreated HL cases diagnosed on lymph node excision biopsy. IHC was performed for EBV LMP1, CD15, CD30, CD45, CD3, CD20.

Results: Patients ranged in age from 5-55years (median 18yrs), with M:F ratio of 3.3:1. Palpable lymphadenopathy was found in all cases followed by pallor (64%), B symptoms (50%), nodal pain (30.8%) & bulky disease (19.2%). Maximum number of patients were in Stage I (65.4%) followed by stage II&III (15.4% each) & stage IV (3.8%). Mixed cellularity HL comprised 77%, lymphocyte depleted 11.5%, nodular sclerosis 7.7% & lymphocyte rich 3.8%. IHC for EBV LMP1 was positive in 73.1% cases. Mixed cellularity HL showed an association in 70% cases.

Conclusions: HL in India is a disease of young males, with mixed cellularity as the commonest subtype, highly associated with EBV and presentation at an early stage.
Paediatric Eyelid Lesions- A Report of 20 Cases
Authors: Sathe Pragati , Asthana Ankita
Published: November 2020

Background: Eyelid lesions are one of the commonest lesions encountered by ophthalmologists in their clinical practice. They could be classified in various ways such as neoplastic or non-neoplastic; congenital or acquired. The common benign conditions affecting the eyelid include cysts like dermoid, epidermoid and epithelial cysts, inflammatory lesions, melanocytic nevi and papilloma. Ignorance about the benign nature of the lesion may lead to increased debility.

The purpose of this study is to contribute information to the literature on various eyelid lesions and their incidence as found in a tertiary hospital.

Methods: This is a retrospective observational study of surgically excised eyelid lesions in patients below 12 years of age. The study was conducted after obtaining permission from the Institutional Ethics Committee.

Result: Out of 20 lesions, 15 cases belonged to the non-neoplastic category while five cases were neoplastic in nature. Cystic lesions predominated in the non-neoplastic category (11 out of 15 cases). The remaining four cases in the non-neoplastic category included three cases of infective etiology and one case of developmental etiology. There were no malignant neoplasms found in our study. The common presenting feature was that of eyelid swelling. Highest incidence of eyelid lesions was in the upper lid (14 of 20 cases, i.e. 66.66%).

Conclusion:

 It is necessary to subject every lesion of the eyelid to histopathological examination. Sometimes, clinically benign lesions turn out to be malignancies which entails a wider surgery later. This study points out to the wide spectrum of lesions that can afflict the eyelid.
Analisis pelatihan online teknis big data menggunakan data logger Moodle
Authors: Kasmanto Rony
Published: November 2020

AbstrakHasil pengamatan perilaku yang dilakukan pada peserta pelatihan daring dapat dijadikan bahan evaluasi untuk penyelenggaraan pelatihan pada masa yang akan datang menjadi lebih optimal. Penelitian ini bertujuan untuk mengetahui perilaku peserta, pengajar dan panita dalam proses pembelajaran dengan keseluruhan daring. Pendekatan penelitian adalah statistik deskriptif dengan menggunakan data logs report pada Learning Management System (LMS) Pusdiklat BMKG. Objek penelitian adalah 50 peserta pelatihan teknis big data yang berasal dari unit pelaksana teknis di BMKG, 13 pengajar dan 2 panitia. Pelatihan diselenggarakan di Pusat Pendidikan dan Pelatihan BMKG pada 28 Oktober sampai dengan 9 Desember 2019. Hasil penelitian menunjukkan bahwa perilaku pelaku pelatihan memiliki aktivitas yang signifikan hanya pada momen-momen tertentu. Sistem LMS mencatat beberapa kejadian: 1) terjadi peningkatan aktivitas peserta, ketika mendekati tenggang waktu pengumpulan semua tugas yaitu pada hari senin dan pada saat pelaksanaan post-test; 2) terjadi peningkatan aktivitas pengajar ketika mendapat peringatan dari panitia untuk pemberian grading terhadap semua tugas-tugas yang dikumpulkan peserta; 3) terjadi peningkatan aktivitas panitia pada saat agenda pembelajaran dimulai dan ketika pelaksanakan post-test. Analysis of big data technical online training using Moodle logger dataThe results of behavioral observations conducted on online trainees can be used as evaluation material for the implementation of future training to be more optimal. This research aims to find out the behavior of participants, teachers, and organizers in the process of full online learning. The research approach is statistically descriptive by using data logs report on Learning Management System (LMS) Pusdiklat BMKG. The research object was 50 big data technical trainees from the technical implementation unit at BMKG, 13 teachers and 2 committees. The training was held at BMKG Education and Training Center from October 28 to December 9, 2019. The results showed that the behavior of trainees had significant activity only at certain moments. The LMS system records several events: 1) there is an increase in participant activity, when approaching the grace period of all tasks that is on Monday and during post-test implementation; 2) there is an increase in teacher activity when it is alerted by the committee to grading all the tasks collected by participants; 3) there is an increase in committee activity at the time the learning agenda begins and when the implementation of post-test.
The role of character education in learning during the COVID-19 pandemic
Authors: Intania Enika Vera , Sutama Sutama
Published: November 2020

Abstract Coronavirus Disease-2019 (COVID-19) has an impact on all aspects of life, including education. Face-to-face education must be transferred to online learning. In learning, both face-to-face and online, character education must always be instilled in students. Character education is an important thing that students must have in order to grow their character, so they can have good personalities In a pandemic such as now, character education is very necessary for students to continue to develop their potential, even though learning is carried out online. The purposes of this study are 1) Analyzing the role of character education in learning; 2) Describing the role of character education in learning in the pandemic era of COVID-19. This type of research is a reference research. The object of this research is the role of character education in learning in the COVID-19 pandemic era. Data validity is done by Triangulation of Sources and Triangulation of Extension. In this study, data analysis techniques used constant comparison. The results of the study are twofold, 1) Character education in learning has a role for students to foster good character that can be realized in their social life; 2) In the pandemic era COVID-19 character education can play a role so that students independently want to learn material and develop an attitude of responsibility towards the tasks given by the teacher in online learning. Peran pendidikan karakter dalam pembelajaran selama pandemi COVID-19Pandemi COVID-19 menimbulkan dampak pada semua aspek kehidupan, termasuk pendidikan. Pendidikan tatap muka harus dialihkan ke pembelajaran online. Dalam belajar, baik tatap muka maupun online, pendidikan karakter harus selalu ditanamkan pada siswa. Pendidikan karakter merupakan hal penting yang harus dilakukan siswa agar dapat menumbuhkan karakternya, sehingga mereka dapat memiliki kepribadian yang baik Di masa pandemi seperti sekarang, pendidikan karakter sangat diperlukan bagi siswa untuk terus mengembangkan potensinya, meskipun pembelajaran dilakukan secara online. Tujuan penelitian ini adalah, 1) Menganalisa peran pendidikan karakter dalam pembelajaran; 2) Menggambarkan peran pendidikan karakter dalam pembelajaran di era pandemi COVID-19. Jenis penelitian ini adalah penelitian referensi. Objek penelitian ini adalah peran pendidikan karakter dalam pembelajaran di era pandemi COVID-19. Validitas data dilakukan dengan Triangulasi Sumber dan Triangulasi Ekstensi. Dalam penelitian ini, teknik analisis data menggunakan perbandingan konstan. Hasil penelitian menunjukkan bahwa 1) Pendidikan karakter dalam pembelajaran memiliki peran bagi siswa untuk menumbuhkan karakter baik yang dapat diwujudkan dalam kehidupan sosialnya; 2) Di era pandemic, pendidikan karakter COVID-19 dapat berperan penting sehingga siswa secara mandiri ingin belajar materi-materi dan mengembangkan sikap tanggung jawab terhadap tugas-tugas yang diberikan guru dalam pembelajaran daring.
Conceito de Valorização Humana
Authors: Rios José de Almeida
Published: November 2020

Encontra-se a Humanidade, na fase atual da Civilização que desfrutamos em uma terrível encruzilhada, cuja decisão salvadora exige uma reformulação dos Valores Humanos não mais visando apenas indivíduos, cidadãos ou personalidades; não mais atendendo classes, povos, Nações ou grupo de Nações, e mesmo raças. Tudo o que for preciso tentar, experimentar, executar ou atingir deverá ser feito. O problema deixou de ser apenas humano para ampliar-se no sentido da Humanidade. Eis a quanto nos conduziu uma simples disputa filosófica, entre Mestre e Discípulo Platão e Aristóteles há cerca de 2.300 anos. Desde então, congregando todos os esforços desenfrearam-se os homens pela filosofia sensorial relegando à margem a integração dos valores espirituais, sentimentais e intelectuais voltados ao interesse do Homem. Hoje temos que considerar este simplesmente como animal, como consumidor ou criador de riquezas ou como comparsa social ou cidadão responsável como uma atenção subsidiária daquela de o julgamento como de nossa própria natureza, com seus defeitos irredutíveis e redutíveis.
Chefia — Sua Significação
Authors: Siqueira Belmiro
Published: November 2020

É sempre oportuno estabelecer o conceito de Chefia, do ponto-de-vista das relações de trabalho. No sentido de evidenciar como a boa Técnica de Direção conduz ao máximo de rendimento e à harmonia entre os indivíduos componentes de uma organização — nunca se escreverá demais.
O Comércio Exterior Como Fator do Desenvolvimento Econômico
Authors: Melo Francisco das Chagas
Published: November 2020

Como já salientamos na publicação "O Comércio Exterior e a Inflação Brasileira”, as transações comerciais representam papel importante, principalmente nos países em fase de desenvolvimento econômico. O comércio exterior influi, diretamente, na formação de renda nacional no nível de vida das populações, na estabilidade monetária e, sobretudo, na taxa de investimentos e na capacidade de instalação de indústrias básicas. O desenvolvimento de um povo está, necessariamente, condicionado à sua capacidade de importar, capacidade essa medida pela exportação e, subsidiariamente, pela obtenção de empréstimos.
Expansão e Aperfeiçoamento das Ciências Administrativas no Brasil
Authors: Peçanha Celso
Published: November 2020

Tendo em vista estimular e aperfeiçoar as Ciências Administrativas n o Brasil, o Vice-Governador Fluminense. Sr. Celso Peçanha, apresentou, quando Deputado, na Câmara Federal, o Projeto nº4.782-58 que dispõe sobre a participação do Instituto Brasileiro de Ciências Administrativas no Orçamento Geral da União, estabelece um Convênio de Colaboração e Assistência Técnica, abre crédito especial pelo Ministério da Educação e Cultura, e dá outras providências. Decorridos alguns meses desde a apresentação d o referido Projeto, precisam ente a 11 de dezembro de 1958, aguarda o I.B.C.A. — que é uma Seção Nacional do «International Institute of Administrative Sciences» — a transformação em Lei da importante proposição legislativa daquele eminente parlamentar.
Um Esboço de Estabilidade aos Chefes
Authors: Fonseca Venero Caetano da
Published: November 2020

São comuns, em todos os ramos da atividade humana, as divergências entre os que elaboraram as formulações teóricas, doutrinárias ou legais e aqueles incumbidos de experimentá-las na vivência dinâmica da realidade prática. Como não poderia deixar de ser, tais divergências ocorrem, também, na Administração Pública. Teoricamente, por exemplo, não deveriam circular nas Repartições listas de adesões a homenagens e donativos, por quebrarem o ritmo de normalidade dos trabalhos e possibilitarem pressões a subordinados, restringindo a liberdade individual. Essa interpretação, construída a distância dos acontecimentos, influenciou o legislador que lhe deu vestes de proibição legal — art. 195, item III, do Estatuto dos Funcionários Civis da União.
Fundamentos e Fatores Psicossociais do Poder Nacional
Authors: Rios José de Almeida
Published: November 2020

Aqui estamos neste momento para impor uma cruzada com o idealismo da parte nova e de cultura exponencial de nosso país. Somos movidos pela determinação de modificar conceitos históricos de vultos eminentes da cultura universal, quando alguns, como Spencer, comparam a história das Nações como aquela própria dos homens. Começam na juventude, com os sonhos, os devaneios e as manifestações do instinto; caminham pela virilidade, com ímpeto, segurança, precaução, firmeza e decisão consciente; chegam à velhice, com desenganos, fraquezas, desalentos e a contemplação pela inércia. Toynbee acredita também nesta sequência. Diz que as civilizações começam muitas vezes sem passado e anonimamente iniciam seu período de grandeza.
As Comissões Permanentes e Temporárias do Poder Legislativo e suas atribuições
Authors: Melo Chagas
Published: November 2020

As comissões do legislativo são de duas naturezas: I — as permanentes que permanecem através das legislaturas e II — as temporárias que se extinguem com a terminação da legislatura ou antes dela, quando preenchido o fim a que se destinam. Organizadas com base na proporcionalidade da representação partidária, as comissões permanentes ou técnicas têm por fim principal estudar os assuntos submetidos regimentalmente, ao seu exame e sobre eles manifestar a sua opinião. O número das comissões permanentes varia com o tamanho da casa legislativa. N a Câmara Federal temos as seguintes comissões permanentes: de Constituição e Justiça, de Economia, Educação e Cultura, Finanças, Legislação Social, Orçamento, Fiscalização e Tomada de Contas, Minas e Energia, Agricultura e Produção Agrícola, Redação, Relações Exteriores, Saúde, Segurança Nacional, Serviço Público e Transporte, Comunicações, e Obras Públicas.
Que São Relações Públicas?
Authors: Chaves Sylla
Published: November 2020

Este artigo corresponde ao primeiro capítulo do livro Relações Públicas, Propaganda e Opinião Pública "A n Introduction to Public Opinion”, primeira de uma série de traduções — Administração para o Desenvolvimento — que a Fundação Getúlio Vargas e a U. S. Agency for International Development estão preparando como contribuição conjunta para o esforço que cada vez mais toma corpo em nosso país. N o volume 94, nº 4 desta Revista expus as razões por que considero relações públicas um fator de integração e desenvolvimento. É preciso, porém, que os técnicos de relações públicas compreendam a importância das suas responsabilidades e correspondam ao que a sociedade espera deles. O grande problema de nosso país em desenvolvimento, em matéria de relações públicas, é, pois, ainda o da definição das responsabilidades que todos temos e que ninguém quer assumir. O importante é combinar a indiscutível força das relações públicas com o imenso potencial deste país, e pô-lo em marcha. N a indicação das responsabilidades, na indicação do caminho a seguir, é que reside a grande contribuição do livro de Childs.
Ciclo de Conferências Promovido pela Divisão de Edifícios Públicos do D.A.S.P.
Authors: Moreira Alberto Lélio
Published: November 2020

De um e de outro lado da Guanabara surgiram duas cidades que pertencem à categoria das capitais naturais; por isso, mesmo efetivada a interiorização da Capital Federal e mesmo que se remova para o centro geográfico do Estado do Rio a fronteiriça Niterói, o problema da intercomunicação destas cidades continuará cada vez mais reclamando uma solução compatível com aquele determinismo geográfico que as predestinou à função precípua de capital, ainda que se lhes retirem os atributos políticos de sede. É lamentável que, embora reconhecida a influência daqueles impositivos geográficos e por todos reclamada a necessidade de uma ponte ou túnel para maior facilidade de circulação entre as duas cidades que socialmente se integram dia a dia, numa intimidade mais profunda, a solução vai se procrastinando com indiscutível prejuízo para ambas.
Pareceres: Consultor Geral da República
Authors: Oliveira A. Gonçalves de
Published: November 2020

No processo anexo, o engenheiro José Caetano Rodrigues Da Horta Júnior requer sua aposentadoria, nos termos do art. 180 do Estatuto dos Funcionários com as vantagens do cargo em comissão padrão CC-3, de Superintendente-Geral de Engenharia ou CC-4 de Chefe do Departamento da Via Permanente da Estrada de Ferro Central do Brasil, por ter exercido cargo em comissão por mais de 10 anos
O aumento de eficiência da administração através da concessão de prémios e incentivos ao funcionário
Authors: Wahrlich Beatriz M. de Souza
Published: November 2020

O presente trabalho se destina a fornecer ao Congresso Internacional de Ciências Administrativas, a realizar-se em Wiesbaden, Alemanha, dados sobre a concessão, no Governo Federal do Brasil, de prêmios e incentivos financeiros aos funcionários com o objetivo de aumentar a eficiência da Administração.
Responsabilidade civil dos Ministros de Estado
Authors: Hugueney Carlindo
Published: November 2020

Quando no século XIII os barões impuseram a João Sem Terra a assinatura de um documento escrito, a Magna Carta, no qual ficava estabelecido que o Chefe de Estado, entre outros fatos, não podia lançar impostos e taxas sem prévia aquiescência dos súditos, estava, em princípio, atingido, em sua maior amplitude, o controle das finanças públicas.
A Presença do Brasil no II congresso Ibero-Americano de municípios
Authors: Cavalcanti Araujo
Published: November 2020

Dentre os fatores determinantes do sucesso obtido, destacam-se a extraordinária capacidade organizadora e a eficiente atuação da Comissão Executiva do Congresso, integrada pelas figuras exponenciais do Conde de Mayalde, Alcaide de Madri, do Prof. Dom Carlos Ruiz dei Castillo, Presidente do Instituto Espanhol de Estudos de Administração Local, de Madri; do Prof. Marcelo Caetano, eminente catedrático e jurisconsulto; do Brigadeiro França Borges, Presidente da Câmara Municipal de Lisboa; do Doutor Macedo de Barros, Secretário Executivo do certame, para citar apenas algumas personalidades da mais alta categoria, responsáveis pelo rigoroso planejamento e execução impecável aa Reunião Ibero-Americana de Lisboa.
Governo e administração do estado da Guanabara
Authors: Cavalcanti Araujo
Published: November 2020

Consagrada em textos constitucionais desde 1891, como imperativo de integração e segurança do Estado, a transferência da Capital da República para o Planalto Central não poderia deixar de figurar em posição de relevo entre os objetivos básicos do Governo Federal e dos Poderes Constituídos, em geral essa relevante aspiração nacional é, hoje, incontestavelmente,uma esplêndida realidade, consubstanciada em fatos concretos que, por sua vez, representam fatores positivos de transfiguração política, demográfica, social, econômica e administrativa do País — através da integração efetiva do «Brasil Interior» na comunidade nacional. Como é do conhecimento geral a transferência da Capital foi levada a efeito em meio a dificuldades aparentemente insuperáveis, sendo a construção de Brasília, de fato, uma decorrência direta e imediata das decisões inflexíveis tomadas pelo Governo e pelo Congresso Nacional.
A legislação Norte-Americana sobre planificação municipal
Authors: Mouchet Carlos
Published: November 2020

A semelhança de organização política e constitucional dos Estados Unidos da América e da República Argentina, torna-se muito aproveitável para nós. As experiências norte-americanas em matéria de planejamento urbano, regional e de áreas metropolitanas, têm-nos sido mais aproveitáveis do que as de outros países, principalmente no que se refere ao aspecto jurídico administrativo.
Terms and Conditions apply: Critical issues for readability and jargon in mental health apps (Preprint)
Authors: Jilka Sagar , Simblett Sara , Odoi Clarissa M. , van Bilsen Janet , Wieczorek Ania , Erturk Sinan , Wilson Emma , Mutepua Magano , Wykes Til
Published: November 2020

BACKGROUND

Mental health services are turning to technology to ease the resource burden, but privacy policies are hard to understand potentially compromising consent for people with mental health problems. The FDA recommends a reading grade of 8.

OBJECTIVE

To investigate and improve the accessibility and acceptability of mental health app privacy policies.

METHODS

A mixed methods study using quantitative and qualitative data to improve the accessibility of app privacy policies. Service users completed assessments and focus groups to provide information on ways to improve privacy policy accessibility, including identifying and rewording jargon. This was supplemented by comparisons of mental health apps with social media, music and finance apps using readability analyses and examining whether GDPR affected accessibility.

RESULTS

Service users provided a detailed framework for increasing accessibility that emphasised having critical information for consent. Quantitatively, most app privacy policies were too long and complicated for ensuring informed consent (mental health apps mean reading grade = 13.1 (SD = 2.44). Their reading grades were no different to those for other services. Only 3 mental health apps had a grade 8 or less and 99% contained service user identified jargon. Mental health app privacy policies produced for GDPR weren’t more readable and were longer.

CONCLUSIONS

Apps specifically aimed at people with mental health difficulties are not accessible and even those that fulfilled the FDA’s recommendation for reading grade contained jargon words. Developers and designers can increase accessibility by following a few rules and should, before launching, check whether the privacy policy can be understood.

CLINICALTRIAL

N/A
An early interactive human coaching via a mobile application to improve quality of life in patients who underwent gastrectomy for gastric cancer: Design and protocol of a randomized controlled trial (Preprint)
Authors: Kim Hak Jin , Yoon Hong Man , Ryu Keun Won , Kim Young-Woo , Kim So Young , Oh Jin Myoung , Wie Gyung Ah , Ko Hyunyoung , Lee Jungeun , Kim Youngin , Eom Bang Wool
Published: November 2020

BACKGROUND

After gastrectomy, patients may experience the postgastrectomy syndrome and face difficulties adapting to everyday diet. Recently, human health coaching via a mobile application (app) has been used for obese patients or patients with chronic diseases, with significant improvements in clinical outcomes.

OBJECTIVE

The aim of this study is to evaluate and compare the effects of human health coaching via a mobile app and conventional face-to-face counseling in patients who underwent gastrectomy for gastric cancers.

METHODS

This study is a single-institution, prospective randomized controlled trial comparing the mobile health and face-to-face counselling groups. After randomization, participants assigned to the mobile health coaching group will receive health coaching via a mobile app for 3 months after discharge, and the assigned coaches will provide personalized advice based on the self-recorded health data. Participants in the face-to-face group will have 1- and 3-months postoperative dietary consultations with a clinical dietitian. The primary endpoint is the food restriction score on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-STO22, and secondary endpoints included all other quality of life scale scores and nutritional parameters. The calculated sample size is 180, and the outcomes will be measured until 1-year post-surgery.

RESULTS

Recruitment started in May, 2020 and currently 51 patients have enrolled in the study. Anticipated date for the completion of enrolment is December 31, 2021 and entire data collection is expected to be completed by December 2022.

CONCLUSIONS

This study will show the efficacy of human health coaching via a mobile app on dietary adaptation in patients who underwent gastrectomy. A relational approach based on personal data and timely intervention using a mobile platform could reduce patients’ trial and error and improve QoL.

CLINICALTRIAL

ClinicalTrials.gov, NCT04394585; http://clinicaltrials.gov/ct2/show/NCT040394585