bluuebunny/crossref_metadata_2025 huggingface dataset:
Step by step diagnosis of hereditary tyrosinemia type I in children
Authors: Namazova-Baranova L. S. , Volynets Galina V. , Nikitin A. V. , Skvortsova T. A. , Karulina A. S. , Smirnov I. E. , Bushueva T. V. , Konova S. R. , Il'in A. G. , Kurbatova O. V. , Potapov A. S. , Gevorkyan A. K.
Published: July 2019

Tyrosinemia type I (HT1) is a rare genetic disease that leads to the development of cirrhosis of the liver, liver failure, and tubulopathy. In this connection there is necessary the early diagnosis and timely initiation of the pathogenetic treatment. The aim of the work was the elaboration of algorithm for a diagnostics of hereditary HT1 in children. We observed 17 children (8 boys and 9 girls) with HT1. There were investigated data of both of the life and disease history ofpatients, there were evaluated changes in clinical and laboratory indices at the onset of the disease. There are established significant clinical and laboratory diagnostic criteria at the onset of HT1 in infants with consequent construction of diagnostic algorithm of this form of pathology. Stepwise diagnosis allows to early detect this disease yet at the first level of the delivery of medical aid in conditions ofprimary health care. Early beginning of specific therapy of HT1 provides for the prevention of disability and death of sick children. Step-by-step diagnostics of HT1 allows to implement the selection ofpatients who need performing of molecular genetic study.
Diagnostic facilities of methods of ultrasound diagnostics in urolithiasis in children
Authors: Dvoryakovskiy I. V. , Akopyan A. V. , Dvoryakovskaya Galina M. , Ivleva S. A. , Zorkin S. N. , Smirnov I. E.
Published: July 2019

There are presented data of the integrated ultrasound (US) examination of 85 children with urolithiasis (IBC) at the age of from 3 months up to 17 years. In traditional ultrasound study (in gray scale mode), the main criterion for the presence of stone - distal acoustic «shadow» was evaluated in dependence on its intensity from 0 to 4 scores. When using color Doppler mapping (CDM) there was established the existence of flaring artifact (FA), which occurred in the reflection of the ultrasonic wave from the reflective stone structure. According to the density index (DI) the presence and density of calculus were detected with the use of Acoustic Structure Quantification (ASQ) methodology for quantifying the structure. The obtained data were compared with data of computed tomography (CT). It has been established that in case of the presence of the «shadow» accounted of 4 scores, FA has been clearly defined, DI ranged from 5,5 to 6,8, CT indices exceed 1100-1500 Hu. When the severity of the «shadow» was of 3 scores, FA remained to be intensive, DI was in the range of 3,5-5,5 and CT density ranged from 800 to 1100 Hu. «Shadow» at 2 scores came from the central department of calculus, FA spectrum corresponded to its width, DI ranged from 3,5 to 2,0 and CT radiodensity - 250 to 800 Hu. Weak «shadow» at 1 score corresponds to a low density stone, FA was narrow, DI ranged from 2,0 to 1,5. At 0 score DI was less than 0,9 and easily permitted ultrasound through. Established patterns indicate to the feasibility of the integrated use of ultrasonic methods in the evaluation of the density of the stone in preparing the patient for performing remote lithotripsy.
Clinical and metabolic features in childhood hypophosphatemic rickets
Authors: Ananin Petr V. , Komarova O. V. , Vashurina T. V. , Zrobok O. I. , Tsygina E. N. , Tsygin A. N.
Published: July 2019

Background: Hypophosphatemic rickets is a rare disease, related to renal phosphate waste, which cause bone deformities, and lead to walking abnormalities and to the reduction in the quality of life. Clinical recommendations in different countries vary in medications, recommended doses and surgery approach. The main aim was to analyze phosphate metabolism in children with hypophosphatemic rickets and to evaluate results of conservative and surgical therapy. Methods: We analyzed medical histories of 15 children with hypophosphatemic rickets and investigated phosphate metabolism, including the measurement of serum intact fibroblast growth factor 23 and X-ray bone densitometry. Routine biochemical tests were assessed with our laboratory reference data, the level of iFGF-23 in hypophosphatemic children was compared with the same values in 18 healthy children. Results: We investigated 15 girls with hypophosphatemic rickets, aged of from 3 years 9 months to 18 years 7 months. All children were treated with alphacalcidol and inorganic phosphate (in dose from 16.21 to 103.3 mg/kg, during from 1 to 114 months). Eleven (73%) children had surgical correction of bone deformations, starting at the age of from 3 to 12 years. Ten (91%) of them had the relapse of bone deformations. Two of four children undergone to the correction of bone abnormalities on alphacalcidol and phosphate therapy without surgery. The level of iFGF-23 in children with hypophosphatemic rickets was 73.11 pg/ml, and exceed iFGF-23 in control group (22.92 pg/ml), p =0,009. Conclusion: Early surgical treatment of bone deformations is not indicated in hypophosphatemic rickets because of risk of recurrence, observed in 91% of our patients. There could be spontaneous correction of bone deformation during conservative therapy, when it is started early.
The risks health for children and adolescents in the process of life activity : problems, methods of assessment, technologies of the managemen
Authors: Kuchma Vladislav R.
Published: July 2019

The assessment of the risk for the health is widely used in international and domestic organizations. The aim of the work is the analysis of methods and techniques of risk assessment for children’s health and determination of the approaches to the analysis of risks for children’s health in the course of their life. The material of the study is based on legal and analytical documents in the field of the analysis of risks for public health. The main method of the research is expert-analytical. Federal Service for Consumer Rights Protection and Human Welfare has proved the risk-based approach to sanitary and epidemiological supervision, classified the subjects of supervision according to the criteria of the potential risk of damage to health. The risks for children’s health, calculated only on the frequency of violations of sanitary legislation, do not take into account the impact of all risk factors for the health of students. Methodology of management of occupational risks (risk management) is now implemented by bioinformatics technologies. The methodology of risk management to children’s health can be applied for pupils in various educational institutions. Risk for pupils ’ health is the probability of the injury as a result of exposure to potentially hazardous and dangerous factors of conditions and modes of learning in the educational activity. The management of risks for health of students is an array of interrelated activities, which includes the measures to identify, assess and reduce the risk for health ofpupils. The criteria of safe conditions and the mode of training of children in educational institutions are the preservation of life, health, functional abilities of the body ofpupils, the upcoming life. The most difficult problem in the hygiene of children and adolescents is the establishment of a causal relationship of diseases with conditions and mode of teaching children and teenagers - causation (causality). The starting point of causation is to establish the diagnosis with a code and factor code from the number of external causes of ICD-10. Risk management is carried out by the system of targeted prevention of school-related diseases.
Actual problems of outpatient pediatrics and their solutions (reflections and offers of the veteran)
Authors: Gracheva Antonina G.
Published: July 2019

There is presented the analysis of the state of ambulatory pediatrics and there are formulated proposals for the priority support for the development of outpatient pediatrics in the framework of improving primary health care for children for the prevention of the shortage ofpediatricians and providing the reduction in morbidity, disability and community-acquired mortality rate. To reduce the long-term shortage of physicians in ambulatory pediatrics author proposes to introduce a new specialty "general pediatrician", which is aimed to prepare a pediatrician at the postgraduate stage for the implementation ofprimary care across all the medicine of children age. The effectiveness of this solution has been proved by the World practice and domestic experiment in the city of Orenburg. It is moreover proposed to use a target distribution of graduates ofpediatric faculty, studied on a budgetary basis, to the outpatient primary care institutions. The organization of postgraduate specialization in ambulatory pediatrics according to the author opinion, should be implemented on the base of Departments of outpatient pediatrics possessing scientific and practical experience in the training of doctors specializing in ambulatory pediatrics.
Neurologic manifestations of cerebral ischemia in infants at 1 year of age
Authors: Smirnov Ivan E. , Stepanov A. A. , Shakina L. D. , Belyaeva I. A. , Bombardirova E. P. , Kucherenko A. G.
Published: July 2019

Hypoxic-ischemic brain damage of the newborn infant to date is the one of the major problems in neonatology. The comprehensive clinical, laboratory and neurological examination of newborns of different gestational ages with perinatal CNS disorder was executed with the use of informative diagnostic technologies. Structural and functional disorders caused by cerebral ischemia, were established to be accompanied by significant changes in brain activity, the severity of which increases with decreasing gestational age of newborns. Certain concentrations of plasma factors of hemostasis in newborns were shown to be markers of the severity of cerebral ischemia and efficiency of complex neuroprotective therapy. Positive neurotrophic effects of gliatilin in the treatment of infants with cerebral ischemia were established to manifest by normalization of the clinical state, neurological symptoms and stabilization of plasma hemostasis, which determined the rate of regenerative treatment of ischemic brain injuries.
Etiopathogenetical aspects and risk factors for in children and adolescents
Authors: Evert Lydia S. , Reusheva S. V. , Zaitseva O. I. , Panicheva E. S. , Potupchyk T. V.
Published: July 2019

According to the research executed in recent years, a significant number of children and adolescents impose periodic complaints ofpain in the neck and other parts of the spine. Back pain (dorsalgia) in children is much less common than in adults; despite that the problem is urgent and debatable not only for pediatricians and neurological practice, but also for other specialties: rheumatology, orthopedics, neurosurgery. The authors discuss the role of the main factors that cause or aggravate pain for this localization. Presented data showed that the latest research methods developed in recent years made it possible to change approaches to the study of pain in the back, to formulate clear etiopathogenic mechanisms and diagnostic criteria that contribute to a deeper understanding of the structure ofpain in the spine and led to the introduction into clinical practice new methods of treatment and prevention.
METHODS OF SCREENING FOR TB INFECTION IN CHILDREN AND THEIR ROLE IN THE FORMATION OF RISK GROUPS AND DIAGNOSIS OF THE DISEASE
Authors: Ovsyankina Elena S. , Gubkina M. F. , Panova L. V. , Yukhimenko N. V.
Published: July 2019

In the review there are presented possibilities of the application of skin immunological tests -Mantoux test (MT) 2TE, as a specific diagnostic test - intradermal Mantoux tuberculin test with two tuberculin units; PPD-L - injectable form of purified tuberculin in standard dilution. L-tuberculin by Linnikova (MT with 2 TE PPD-L = MT) and samples with recombinant tuberculosis allergen (RTA) for the formation of high-risk groups and diagnosis of TB infection in children. Screening investigations with the use of MT have a high sensitivity (95-98%), which is an advantage of MT as the evidence base. The insufficient sensitivity of the Diaskintest® skin test (DST) preparation has been established by independent researchers (78-85% of cases of active TB are missed). The special attention was shown to have to assess the cost effectiveness of screening tests with RTA. 98% of negative results in the screening with RTA were revealed to be very expensive unreasonably. These patients failed to come in sight of health professionals, although among them there may be cases with different stages of latent TB infections requiring medical supervision by phthisiatrician. To solve the issue concerning mass application of RTA test its safety profile should be studied.
RICKETS, VITAMIN D DEFICIENCY, AND GLOBAL CONSENSUS RECOMMENDATIONS ON PREVENTION AND MANAGEMENT OF NUTRITIONAL RICKETS: RUSSIAN PEDIATRICIANS’ OPINION
Authors: Studenikin Vladimir M. , Kazakova K. A. , Akoev Yu. S. , Migali A. V.
Published: July 2019

The article focuses on Global Consensus recommendations on prevention and management of nutritional rickets (2016), created by 33 foreign experts, representing 11 pediatric communities from 18 countries. Positive and negative aspects of these Consensus recommendations are reviewed and carped when necessary. The need for the development of Russian national consensus on rickets prevention and management is noted.
BIOCHEMICAL AND MOLECULAR GENETIC DIAGNOSIS OF TYROSINEMIA, TYPE 1 IN RUSSIAN PATIENTS
Authors: Mazanova N. N. , Savost’Yanov K. V. , Namazova-Baranova L. S. , Baranov A. A. , Pushkov A. A. , Murav’Eva L. V. , Sukhozhenko A. V.
Published: July 2019

Tyrosinemia type 1 (OMIM 276700, E70.2) is a rare hereditary form of the disorder of metabolism caused by the deterioration of tyrosine metabolism emerging due to pathological change in the reference sequence of the FAH gene coding fumarylacetatoacetate hydrolase. The reduced activity of this enzyme leads to the accumulation of a maleylacetoacetate, fumarylacetatoacetate and their derivatives: succinylacetatoacetate and succinylacetone which exert toxic effect on tissues of human body especially on liver and kidneys cells. Implementation of the method of tandem mass-spectrometry allowed to carry out early screening diagnostics of tyrosinemia type 1 in dry blood spots, both to save significantly staff and timing resources and avoid difficulties due to biomaterial transportation and storage. Molecular and genetic methods allowed to reveal new mutations and mutations common for Russian patients, also they made possible to carry out genetic counseling in families with the use of prenatal and pre-implantation diagnostics that in turn allowed to carry to term and give birth to three healthy children in families with family history. The presented changes of tyrosine and succinylacetone concentrations in blood of the examined patients before and during treatment showed modern options of the personified pathogenetic treatment and nutritional management of the tyrosinemia type 1 patients
CURRENT CONCEPTS OF ATOPIC DERMATITIS IN CHILDREN: PROBLEMS AND PROSPECTS
Authors: Smirnova Galina I.
Published: July 2019

There are presented modern data describing the current understanding of the pathogenesis of atopic dermatitis (AD): a genetic predisposition to atopy, disruptions of epidermal barrier integrity and a cascade of immune responses, contributing allergic inflammation in the skin. There are both described several mechanisms of acute and chronic phases of AD, the main directions of pathogenetically substantiated treatment of AD in children and indicated the prospects of new preparations specific blockers of proinflammatory cytokines involved in the development of AD - crisaborole, apremilast, dupilumab, lebrikizumab, tralokinumab, tezepelumab. There is especially presented in details external therapy of atopic skin lesions in children with the use of means of modern dermatological cosmetics.
CLINICAL APPLICATION OF MASSIVE PARALLEL SEQUENCING IN MOLECULAR DIAGNOSTICS OF HEREDITARY DISEASES OF GLYCOGEN ACCUMULATION IN THE CHILDREN POPULATION OF THE RUSSIAN FEDERATION
Authors: Savostyanov Kirill V. , Surkov A. N. , Namazova-Baranova L. S. , Zhanin I. S. , Pushkov A. A. , Basargina E. N. , Nikitin A. G. , Potapov A. S. , Pakhomov A. V. , Baranov A. A.
Published: July 2019

There has been developed and validated the technology for massive parallel sequencing for the purpose of molecular genetic diagnosis of hereditary glycogen storage diseases. Among 96 patients aged of from 15 months up to 18 years, the diagnosis was verified in 89 (92.6%) children. Glycogen storage disease (GSD) type IX appeared to be the most frequent form of glycogenosis in children, diagnosed in 29.3% of cases, GSD type IV, verified in 1.1% of cases, was a rare form of glycogenesis. In 39 (43.8%) out of 89 genetically confirmed children, there were revealed 35 (44.3%) of the previously undescribed mutations from 79 pathogenic variants found in 9 (45%) of different genes of 20 examined cases, indicating to a significant heterogeneity of genetic factors of the development of GSD in the Russian population. Mutations c.247C>T of the G6PC gene, c.1042_1043del of the SLC37A4 gene, c.3980G>A and c.1423+1G>A of the AGL gene, c.-32-13T>G of the GAA gene, and c.884G>A of the PHKA2 gene were been established to be characteristic for the Russian population of GSD children. There was shown the high sensitivity and specificity of the massive parallel sequencing for the search for single nucleotide substitutions in coding and adjacent intron regions, as well as small deletions and duplications of genes, mutations in which lead to the development of GSD. Massive parallel sequencing is necessary for the rapid diagnosis of GSD, timely appointment of the adequate treatment, prevention of complications, which will improve the quality of the life of GSD patients.
THE QUALITY OF PROPHYLACTIC CHECK-UPS OF FIRST-YEAR OLD BABIES IN THE OUTPATIENT SETTING
Authors: Balashova Elena A.
Published: July 2019

Quality of healthcare on the first year of life in the outpatient setting was evaluated by availability of obligatory data in medical forms of 230 13-year-old children (group I) and 210 3-year-old children (group II): body weight and body length at birth and at the age of 12 months, the duration of breastfeeding. There was executed the assessment of the quality of medical care for infants of the first year of life in a children's polyclinic according to the presence in the form 112/u data that are mandatory for the reflection: body weight and body length at birth, duration of the natural feeding, body weight and body length at the age of 12 months. By means of the method of continuous sampling, forms 112 /u have been selected for 230 children of 13 years and 210 children of 3 years (440 in total). Anthropometric parameters at birth are reflected in the majority of children: weight at birth is not reflected only in 2.9% of children in group 1 and in 0.9% of children in group 2; the birth body length is not indicated in 3.8% and 1.3% of children, respectively. At the age of 12 months anthropometric data were absent in 15.7% (for weight) and 18.1% (length) of children in group 1 and 20.4% (for weight) and 21.3% (length) in the 2nd group of children. Thus, practically in 20% of children it is impossible to estimate the level of physical development at the age of 1 year. In those cases when anthropometric indices were reflected, in more than 80% of children an analysis of physical development was not executed. The duration of breastfeeding was not reported in 22.9% of children of group I and in 45.7% of group II. 3.0% of children are formula-feeding from the birth but calculation of the formula was not found. Complete blood count during the first year of life was not performed in 4.8% of children of group I and in 1.7% of children of group II. Parents of children from the group I refused vaccination in 5.2% of cases. During ten years, the failure rate increased up to 11.7%. In no case, the waiver was attached to medical forms.
MEDIATORS OF ENDOTHELIAL DYSFUNCTION IN CEREBRAL ISCHEMIA IN PREMATURE INFANTS
Authors: Smirnov Ivan E. , Kucherenko A. G. , Belyaeva I. A. , Shakina L. D. , Postnikova E. V. , Bombardirova E. P. , Kharitonova N. A.
Published: July 2019

N preterm infants with cerebral ischemia, the blood level of such mediators of endothelial dysfunction (MED), as endothelin-1, nitric oxide, angiotensin II, homocysteine, neurotrophic factors, tissue type plasminogen activator and von Willebrand factor was quantified. The established patterns of changes in the blood level of these mediators, depending on the degree of prematurity and severity of cerebral ischemia, reflect the severity of impairment of the functional state of the endothelial system. The quantitative data on the blood MED level in premature infants can be considered as criteria for the assessment of the degree of endothelial dysfunction, as in choosing modes for adequate timely correction of cerebrovascular disorders in newborns.
THE PHYSICAL DEVELOPMENT OF RURAL SCHOOLCHILDREN WHO ARE BROUGHT UP IN THE FAMILY AND IN THE BOARDING SCHOOL
Authors: Belkina Elena I. , Kuznetsova T. A.
Published: July 2019

There was made an assessment of the physical development of 319 rural schoolchildren who are brought up in families and in boarding schools. Anthropometric data of boys and girls aged 6-17 of years were analyzed. Normal growth rates for 91.3-94.3% of rural schoolchildren were established; Tall children were more often identified in families, and undersized one were revealed among those living in boarding schools (up to 8.9%). Normal values of body mass index were determined in 69.7-88% of schoolchildren; Overweight - in 10-26,9%, and body mass deficit - in 1,9-3,4% of children. In children living in families, high values of body mass index were detected by the order more often than low values (21.9-26.9% and 1.9-3.4%). In boarding students, the body mass index was the same in all age periods. Normal ratios of waist circumference to hip circumference were determined in 66.7-90% of schoolchildren. In this case, the predominant deposition of fat on the hips was found only in boys (25.7-33.3%); Abdominal fat deposits were found in 2.9% of boys living in families and in 10-17.6% of girls living in families and boarding schools. The authors believe that irrespective of the living conditions (family or boarding school), rural schoolchildren develop changes in the distribution of fat, possibly due to the peculiarities of the pubertal period.
PREVENTION OF ORPHAN DISEASES: CONTEMPORARY ASPECTS AND NEW CHALLENGES
Authors: Shavaliev R. F. , Yafarova Sabina Sh. , Volgina S. Ya.
Published: July 2019

The authors represent current data concerning the management of the prevention of orphan diseases. Determinations of modes and levels of the prevention have been formulated. The importance of pre-gravity care, medical genetic counseling, assisted reproductive technologies, methods of prenatal diagnosis and fetal surgery, neonatal screening at certain stages of the organization of preventive measures is reflected. Specific features of screening for rare diseases with the use of rapid diagnostics methods are described: a solid approach, mass character, preventive orientation and stage-by-stage approach. Topical issues of the prevention of orphan diseases are considered.
THE ‘FATHERS OF THE SOVIET PEDIATRICS’: YU.F. DOMBROVSKAYA AND A.F. TUR
Authors: Mikirtichan Galina L.
Published: July 2019

This article, dedicated to the 90th anniversary of the Society of Children’s Doctors of Russia, presents short biographical reviews of the most prominent Russian pediatricians: Yu.F. Dombrovskaya (1891-1976) and A.F. Tur (1894-1974), the academicians of the Academy of Medical Science of the USSR, Honoured scientists of the Russian Federation, laureates of the Lenin Prize in 1970. Their high professionalism and achievements in scientific and clinical pediatrics, exceptional personalities and their special style of communication with colleagues, pediatric patients and their parents were reasons for these pediatricians gained the highest respect in medical circles. Both of them took part in all congresses of pediatricians that were held in their lifetime and presented major papers at most of them. A.F. Tur was elected the president of the Society of Children’s Doctors of the Russian Federation in 1957, and Yu.F. Dombrovskaya was elected the president of the Board of the Society of Children’s Doctors of the USSR in 1962. Under the chairmanship of Yu.F. Dombrovskaya there were held three congresses of the Society of Children’s Doctors of the USSR, A.F. Tur was elected the chairman at four congresses of the Society of Children’s Doctors of the Russian Federation. Between the congresses, a number of conferences and meetings were held (pan-Soviet-Union, pan-Russian-Federation, regional, municipal). The activities of both Societies of Children’s Doctors - of the USSR and the Russian Federation - have contributed a lot to the improvement of qualifications of pediatricians, clinical and prophylactic activities, specific medical aid to children, using a wide range of new technologies in theory and practice of pediatrics, positive changes in health indexes of children.
DEVELOPMENT AND EVALUATION OF THE EFFECTIVENESS OF THE HEALTH SCHOOL FOR CHILDREN WITH OBESITY UNDER THE CONDITIONS OF THE CHILD POLYCLINIC
Authors: Martynova I. N. , Vinyarskaya Irina V.
Published: July 2019

The article is devoted to the development and evaluation of the effectiveness of the organizational model of rendering medical care to children with obesity: «Health School - Weight Control». Тhis is a modern preventive technology. The main direction in its activity is the creation and maintenance of the motivation of the family and child with excessive body weight and/or obesity to a healthy lifestyle. Its tasks include the raise the awareness of family members and children with obesity about the disease, development of practical skills for eliminating unhealthy habits, and improvement of the quality of life of patients and their relatives. To assess the effectiveness of the Health School, not only the anthropometric method was used, but also indices of the quality of life of children and adolescents according to the questionnaire «Pediatrics Quality of Life Inventory (PedsQLТМ 4.0)». The study involved 50 patients aged of from 8 to 18 years. 75% of patients showed a gradual weight reduction during the year. The analysis of the dynamics of the quality of life revealed a statistically significant increase in all the components of indices in children involved in the Health School, especially in aspects of emotional and role functioning. The developed model of rendering medical care to patients with obesity allowed optimize the organization of treatment and preventive care for this category of patients.
PROBLEMS AND IMPROVEMENT WAYS OF MEDICO-SOCIAL ASSISTANCE TO THE DISABLED CHILDREN AT THE OUTPATIENT STAGE
Authors: Zhdanova L. A. , Boboshko Irina E. , Molkova L. K. , Rogacheva N. K.
Published: July 2019

The article highlights the persistent problems of rehabilitation of children with health disorders and the necessity of improving assistance to the disabled children. The improvement of the efficiency of rehabilitation measures is possible by means of the optimization of both the inner and interagency integration in the organization of assistance to children with disabilities, a clear algorithm of collaboration and document circulation between specialists of the departments of children’s polyclinic and the Bureau of Medical Social Expertise, creation of individual integrated programs and raising the awareness of patients with the quality of assistance.
FEATURES OF THE DIAGNOSIS OF UNCOMPLICATED COMPRESSION FRACTURE OF THE THORACIC SPINE IN CHILDREN
Authors: Yakhyaev Yakhya M. , Izrailov M. I. , Merkulov V. N. , Aliskandiev A. M. , Yakhyaeva T. Ya.
Published: July 2019

X-ray diagnostics of compression fractures of bodies of the thoracic vertebrae in children not seldom causes great difficulties due to the fact that even in healthy children vertebrae have a number of features, particularly, the wedge shape. For the purpose of differential diagnosis there was performed chest X-ray examination of the thoracic vertebrae in healthy children and cases after the compression damage. The wedge index and the disk coefficient for various segments of the thoracic spine were calculated. The diagnostic efficiency of radionuclide studies was estimated to reaches 79%. The useof highly informative modern medical techniques (CT and MRI) in the diagnosis of vertebral compression fractures in children allows accurately and timely make the diagnosis and determine the condition of the surrounding tissues. Based on the analysis of medical records, radiographs, identification of options of radionuclide, CT and MRI studies, there was elaborated an algorithm for the diagnosis of compression fractures of vertebrae, which allowed optimize the diagnostic process. There are determined advantages of this algorithm.
RISK FACTORS FOR THE PREVALENCE OF BRONCHIAL ASTHMA IN CHILDREN AND ADOLESCENTS IN THE MOUNTAINOUS ZONE OF DAGESTAN
Authors: Izrailov Magomed I. , Aliskandiyev A. M. , Yakhiaev Ya. M.
Published: July 2019

The prevalence of bronchial asthma (BA) in recent years has been steadily increasing in many countries of the world. Among allergic diseases and respiratory diseases, asthma occupies a leading position. In order to study the prevalence of asthma, we performed questionnaire survey of 6326 schoolchildren, including 3125 cases aged of 7-8 years and children of 13-14 years according to the «ISAAC» program. The prevalence of bronchial asthma in children in the mountain climate is about 8.43 per 1,000 children, which is almost two times lower than in the low-lying zone, in urban children the prevalence of bronchial asthma is 25 per 1000 children. Among the risk factors for the formation of bronchial asthma in children the leading place is occupied by hereditary, occupy antenatal and social sanitary risk factors.
ANDREY VLADIMIROVICH MAZURIN - CHAIRMAN OF THE ALL-RUSSIAN SOCIETY OF PEDIATRICIANS
Authors: Zaprudnov Andrey А.
Published: July 2019

The article highlights the contribution of the corresponding member of the |Russian Academy of Medical Sciences of the USSR, Professor A.V. Mazurin to the development of the Russian scientific society of pediatricians., Professor A.V. Mazurin was the Chairman of the All-Russian Scientific Society of Pediatricians from the 1987 to 1993, receiving the baton from outstanding pediatricians of our time - academicians A.F. Tour and V.P. Bisyarina. There are discussed origins of the development of pediatric gastroenterology as one of the topical areas of domestic Pediatrics. By developing this direction in difficult years, like many others, A.V. Mazurin paid a lot of attention to preserve and multiply the glorious traditions of Russian pediatric science and practice.
Contribuição do BIM no processo de quantificação de CO2 no projeto de edificações: estudo de caso com o software Autodesk Revit
Authors: Araújo Moacy , Sattler Miguel Aloysio
Published: July 2019

A necessidade da produção de ambientes mais sustentáveis se multiplica a cada dia. Para suprir tal necessidade, é de suma importância que a concepção de novas edificações seja voltada para a sustentabilidade. Pelo grande consumo de matérias primas e elevado consumo energético, a indústria da construção civil é a grande geradora de impactos. Entretanto, já existem ferramentas auxiliadoras no processo de criação de edificações mais sustentáveis, como o uso do Building Modeling Information (BIM). Neste contexto, o objetivo desse trabalho é aplicar uma ferramenta BIM na análise do ciclo de vida de edificações, mostrando que é possível obter-se uma estimativa da quantidade de CO2 incorporado emitido ainda na fase de projeto, tornando viável a escolha de matérias e métodos construtivos mais sustentáveis, uma vez que qualquer alteração feita no projeto dentro do software acarreta em uma atualização em tempo real dos cálculos de emissão de CO2. Para isso, usou-se o projeto de uma casa sustentável de baixo custo. Contudo, conclui-se que o software atende às expectativas, mas o processo de inserção de dados ainda é um pouco trabalhoso.
AN ASSESSMENT OF THE AESTHETIC VALUE OF THE ISLAMIC UNIVERSITY MOSQUE IN CONSTANTINE
Authors: Said Bousmaha , Chergui Samia , Zouaoui Mustapha Cheikh
Published: July 2019

Contemporary architecture increasingly stands out as a new area of cultural heritage. The "religious patrimony of the future" is one of the principal components which fits naturally into the logical process of preservation and transfer, of the architectural heritage from one generation to the other. The patrimonial process represents the only way to identify and evaluate these "prominent qualities", through different methods of evaluation. this study aims to assess the aesthetic value, considered as one of the essential characteristics of the university mosque in Constantine. It also aims to trigger its heritage process. The methodology was for quantitative and qualitative analysis (quaternaries and formal investigation). The analysis of its outward composition and overall form fits not only into a specific theoretical framework related to the philosophy of art and the subjectivity of beauty perception but depends more on an "in situ" investigation. The evaluation criteria adopted for this study focuses on the values of balance, dominance, unity and variety as well as the parameters of rhythm, proportion and perfect angles. The finding of this study reveals that these criteria made evident different constructive logics used at this university mosque such as the use of Doric proportions and privileged angles, which could serve as an objective argument in according aesthetic value to this mosque in Constantine and prepare its patrimonial future as a religious heritage for future generations.
SEMANTIC ANALYSIS OF FRAUDULENT ADS IN FACEBOOK
Authors: Rais Burhanudin , Widodo Pratomo
Published: July 2019

This study aims to analyse the semantic features in fraudulent ads in Facebook. This study is conducted by using two kinds of advertisement which are found in Facebook. The researchers are analyzing the word, sentence, or phrase that suspected as the way to convince the customers by following theory of meaning from Leech (1981). The data that the researchers got showed that the first type of advertisement is emphasized more to the affective and social meaning where the seller leads the customers’ opinion that the seller is a good or trusted person. Moreover, the seller uses prase that include to conceptual meaning to explain the condition or specification of the cellphone in detail.In the second type of advertisement, the element emphasized by the seller is thematic mining by referring to the emphasis of the word used in the advertisement.More over, theresult for identification of fraudulent ads in this study is still dominated by the usual way, such as by looking at the price offered. However, the results of this study can also be used as a consideration in identifying fraudulent ads.
“THE SHAWL”, THE SUBALTERN, AND THE CASE OF THE SUBALTERN GENOCIDE
Authors: Gultom Natan
Published: July 2019

Holocaust studies post-World War II have found ways in intersecting to other studies within the Postmodern era. In 1980, a short-story “The Shawl” was written depicting a holocaust brutality done towards the Jews. The story revolves around a Jewish woman, Rosa, that lived through the bitterness of seeing her daughter, Magda, being slaughtered in a concentration camp. In the context of “The Shawl”, this article would like to describe the relationship between holocaust studies and the subaltern studies within postcolonialism. Furthermore, this article discusses if there are hints “The Shawl” invokes a sentiment for the Jews to take revenge towards their former oppressors. The aim of this article is to further the argument “The Shawl” has no characteristics of taking revenge which eventually leads to subaltern genocide. “The Shawl” functions better as a remembrance so generations of the future do not repeat the horrors of the past.
Los colectivos mediáticos de las redes. Algunas observaciones desde el humor ¿y más allá?
Authors: Fraticelli Damián
Published: July 2019

En este artículo se intenta contribuir a la comprensión de los colectivos mediáticos siguiendo la línea de trabajo iniciada por Eliseo Verón y continuada por Mario Carlón. En primera instancia, se sintetizan las propiedades con que Verón caracterizó a los colectivos mediáticos diferenciándolos de otros tipos de colectivos. Luego, se trabaja en la apropiación del concepto que hizo Carlón al ocuparse del nuevo sistema mediático. Finalmente, se distinguen algunas cualidades de los colectivos hipermediáticos halladas en las investigaciones realizadas sobre los youtubers y lo risible en las redes. Entre ellas se destacan la individuación de los integrantes del colectivo y una interacción entre ellos y el enunciador de la cuenta factible de ser planteada como un sistema de producción discursiva
La proyección online del yo entre individuación y colectivización
Authors: Moreno Barreneche Sebastián
Published: July 2019

Las prácticas vinculadas con la proyección de la identidad personal que se llevan a cabo en medios digitales pueden y deben ser concebidas como prácticas de comunicación y, más ampliamente, de significación. Desde un enfoque semiótico, tales prácticas pueden ser concebidas como estrategias de enunciación del yo en las que los individuos, a través de actos creativos que implican la manipulación del plano de la expresión, consciente o inconscientemente gestionan la imagen que proyectan ante el mundo externo con ciertos fines estratégicos, para producir un determinado efecto de sentido en cómo los demás los concebirán. El objetivo de este artículo es presentar una reflexión que ayude a concebir las prácticas de proyección del yo online como el resultado del empleo de una serie de recursos semióticos, apoyadas en una dinámica que oscila permanentemente entre dos polos: la individuación y la colectivización. Como en todo proceso de construcción identitaria, la proyección online de la identidad personal refleja esta necesidad de la dimensión colectiva para afirmar lo que es individual y único. La propuesta teórica se ilustra a partir de la presentación de ejemplos de creación de perfiles personales individuales en Instagram.
Los públicos entre producción y recepción. Problemas para una teoría del reconocimiento
Authors: Verón Eliseo
Published: July 2019

En la actualidad, los estudios sobre los medios se encuentran, me parece, en una situación bastante confusa. Esta confusión es en buena parte el resultado de la reorientación de la investigación, desde hace una veintena de años, sobre los fenómenos de la recepción. Ahora bien, ¿cómo se hace para que esta reorientación, de la que podemos tener la sensación de que nos hará complicar aún más la cuestión de la circulación mediática, haya podido desembocar en un panorama crítico o, en todo caso, en un malestar generalizado?
La mediatización en perspectiva semioantropológica. Entrevista a Oscar Traversa
Authors: Cingolani Gastón , Fernández Mariano
Published: July 2019

Oscar Traversa ha venido investigado y enseñando sobre la mediatización y las transformaciones en los vínculos y las articulaciones entre lo individual y lo colectivo desde hace varias décadas. De hecho, fundó la primera cátedra universitaria en Argentina sobre historia de las mediatizaciones, cuando los materiales y las investigaciones al respecto eran escasos. En los últimos años parecen haber proliferado las reflexiones sobre la exacerbación de la mediatización entre individuos que se acopla, de una manera despareja y quizá novedosa, a la tradición de estudios del siglo XX, ligada (aunque no únicamente) a la mediatización de uno a muchos o broadcasting. Eso ha generado nuevas observaciones, debates y la aparición de algunos objetos de análisis interesantes, pero también algunas imperfecciones teóricas (esto es un juicio compartido por los entrevistadores) que quieren ver más “novedades” de las que verdaderamente se han producido.
Capitalismo de plataformas
Authors: Amarilla Laura
Published: July 2019

Capitalismo de plataformas de Nick Srnicek (2018) es un ensayo que, como indica su título, estudia la articulación entre el sistema capitalista y los nuevos agentes que intervienen en él: las plataformas. El libro se divide en tres capítulos (más un apartado con una entrevista al autor) en los que se presenta una propuesta alternativa a través de la historia económica del capitalismo y la tecnología digital, un espacio de vacancia respecto de las investigaciones de referencia y la diversidad de formas económicas, y las tensiones competitivas inherentes a la economía contemporánea.
Kulit Kacang Tanah (Arachis hypogaea L.) sebagai Adsorben Ion Pb(II)
Authors: Oktasari Ade
Published: July 2019

An experiment on Pb (II) metal ion adsorption using peanut (Arachis hypogea L.) shell without activation (KK), acid-activated (KKA), and base-activated (KKB) has been conducted. Peanut shell powder was activated using H3PO4 and KOH to improve adsorption effectivity and capacity. Characterization results using FT-IR spectrophotometer showed peak at 3410 and 2901 cm-1 indicated OH dan CH aliphatic from framework of cellulose. Optimum condition of Pb(II) adsorption for KK, KKA and KKB was occurred at the same optimum pH, that was pH 5, with contact time 60, 90 and 70 min, respectively. The adsorption kinetic parameter of Pb(II) ion for KK, KKA, and KKB followed pseudo second order kinetic with rate constants (k) in order of 12.279, 4.149, and 32.258 g mmol-1 min-1, with maximum adsorption capacity based on Langmuir isotherm model of 0.598, 0.505, and 0.622 mmol g-1, and adsorption energy of 26.735, 25.789, and 29.245 kJ mol-1, respectively. The results indicated that KOH-activated peanut (Arachis hypogea L.) shell has good adsorption affinity for Pb(II) with highest adsorption capacity compare to those from non-activated and acid-activated.
Penentuan Kadar Amonia (NH3) pada Limbah Cair K-34 dalam Rangka Pengendalian Pencemaran Lingkungan
Authors: Gova Muhammad Agil
Published: July 2019

Free Ammonia is an ammonia did not react perfectly with Carbon Dioxide in the process when producing urea. Free ammonia did not bond with urea directly but it bonded in grain. This reaserch purposed to know how to determine Ammonia’s degree, to know how to use Spektrofotometer to look for the value of Ammonia absorbance, and to know how to make Reagent Nessler A. The method for this research is method which combine qualitative and quantitative by checked the change color of the sample, which is the sample has been reacting with Reagent Nessler A. This reaserch used Spektrofotometer Uv-Vis as an instrument to detemine Ammonia absorbance. The average result of Ammonia (NH3) degree in canal 34 it was site the third Pusri it was gotten 186 ppm, and the average of pH Ammonia (NH3) for canal 34 was 8,34, and the highest average of Ammonia (NH3) degree was 280 ppm and the highest pH Ammonia (NH3) is 9,2. All of the result were in quality standard based on Ministry regulation no. 5 which issued in 2014.
EFEKTIVITAS MANAJEMEN KELAS KELOMPOK BERMAIN PADA PAUD BON THORIF PALEMBANG
Authors: Amilda Amilda
Published: July 2019

Efektivitas manajemen kelas kelompok bermain pada PAUD Bon Thorif Palembang dimaksudkan untuk menciptakan proses pembelajaran efektif. Hal tersebut dilakukan dengan 1). Menciptakan lingkungan belajar yang kondusif, 2). melakukan pengaturan sedemikian rupa pada waktu untuk melakukan aktivitas bagi anak ini dilakukan dengan pertimbangan fleksibelitas dan mengacu pada karakteristik anak, 3). Mengatur Ruang Kelas, dengan cara mengatur ruang kelas, posisi duduk, pengaturan perabot dan alat permainan, serta membagi ruangan.Adapun faktor yang mempengaruhi efektivitas manajemen kelas kelompok bermain pada PAUD Bon Thorif Palembang adalah 1). Lingkungan fisik yang tidak mendukung, Seperti: kondisi kelas yang gaduh karena aktivitas anak seperti megobrol, berselisih, berteriak dan lain sebagainya sehingga mengganggu aktivitas belajar dikelas, b). Terdapat anak tidak bisa tenang seperti berlari-lari di dalam kelas, dan anak-anak lainnya tampak berkeluyuran tanpa tujuan, c). Ruangan kelas yang kacau balau akibat aktivitas anak, d). Penempatan perabot yang tidak mempertimbangkan penggunaan oleh anak sehingga  mengganggu aktivitas anak lainnya, 2) Lingkungan fisik yang mendukung seperti: Hasil pekerjaan anak-anak dipajangkan, tumbuhan hijau yang sehat di seluruh ruangan, poster berwarna-warni di dinding, dan gorden baru di jendela, ruangan diatur dalam area aktivitas yang berbeda, terdengar senandung berbicara dan tertawa, tetapi tidak ada teriakan, anak-anak sedang mengerjakan beberapa aktivitas yang diatur oleh para guru, material disimpan di atas rak terbuka yang rendah, dan anak-anak dapat menjangkaunya dengan mudah, fasilitas dan peralatan ditempatkan berdekatan dengan aktivitas yang akan dilakukan anak seperti kran air, ember, dan spons, anak-anak tampaknya benar-benar menikmati kegiatan pembelajarn dengan senang dan gembira, serta peran guru tampat sebagai fasilitator dan pembimbing dimana guru berupaya menasihati anak-anak dari suatu perubahan aktivitas ke bentuk aktivitas lainnya yang dirancang.Dengan demikian maka secara komprehensif dapat dikemukakan bahwa efektivitas manajemen kelas kelompok bermain pada PAUD Bon Thorif Palembang dimaksudkan untuk menciptakan proses pembelajaran efektif dengan cara melakukan perencanaan dengan mempertimbangkan karakteristik dan perkembangan anak.
UPAYA MENINGKATKAN KEMAMPUAN MOTORIK HALUS MELALUI MEDIA PLAY DOUGH
Authors: Putri Yecha Febrieanitha
Published: July 2019

Penelitian bertujuan untuk mengetahui apakah kemampuan motorik halus dapat ditingkatkan melalui media play dough. Penelitian dilaksanakan pada kelompok A PAUD Adzkiyah Desa Sukarami dengan jumlah anak yaitu 12 orang yang dilaksanakan tahun 2018. Penelitian ini menggunakan metodologi penelitian tindakan kemmis dan taggart dengan menggunakan 2 siklus masing-masing siklus dilakukan 3 pertemuan. Setiap pertemuan dilakukan dengan empat kegiatan yaitu. Perencanaan, tindakan, observasi dan refleksi. Analisis data menggunakan analisis data analisis data kuantitatif dan analisis data kualitatif. Analisis data kuantitatif diperoleh dari diskripsi nilai pra-siklus, siklus satu dan siklus dua. Sedangkan analisis data kualitatif diperoleh dari catatatan lapangan, catatan dokumentasi dan catatan wawancara dengan menggunakan empat bagian yaitu data reduction, data display dan data kesimpulan. Hasil dari penelitian kemampuan motorik halus melalui media play dough di kelompok A PAUD Adzkiyah Desa Sukarami mengalami peningkatan pada setiap siklusnya. Nilai pada siklus 1 yaitu sebesar 61,17% kemudian meningkat ke siklus 2 menjadi 80,08%.

           

Kata Kunci: kemampuan motorik halus, media play dough
PERAN AL WARAQ DALAM INDUSRI PENERBITAN BUKU ISLAM DAN DAMPAKNYA TERHADAP PERKEMBANGAN KEILMUAN ISLAM
Authors: Santoso Budhi
Published: July 2019

Introduction. This article discusses intellectual development in the Islamic world and the role of al-Waraq in the Islamic book publishing industry.

Data Collection Method.  The method used in this article is the literature study method used in obtaining data.  

Analysis Data. The data obtained is then grouped according to relevance to the formulation of the problem

Results and Discussions. The copying of scientific texts is very instrumental in the spread of knowledge, besides being a copyist of the Al Warraq manuscript, it also acts as editor and publisher of books. that. With the existence of this catalog, we can find out the number of publications at the time and as literature for the study of Muslim works in the golden era. Copyright licenses are issued to avoid plagiarism or recognition of a work by Al Warraq. The Al Warraq profession was slowly displaced by the discovery of printing technology in the fifteenth century.

Keyword: al warraq, Islamic scientific development, Islamic Book Publishing Indusrial