bluuebunny/crossref_metadata_2025 huggingface dataset:
Midterm Results After Abandoning Routine Preemptive Coil Embolization of the Internal Iliac Artery During Endovascular Aneurysm Repair
Authors: ‘t Mannetje Yannick W. , Broos Pieter P. H. L. , Teijink Joep A. W. , Stokmans Rutger A. , Cuypers Philippe W. M. , van Sambeek Marc R. H. M.
Published: March 2019

Purpose: To analyze the results of endovascular repair of common iliac artery (CIA) aneurysms without preemptive coil embolization of the internal iliac artery (IIA). Materials and Methods: Between January 2010 and July 2016, 79 patients (mean age 74.3±8.4 years; 76 men) underwent endovascular repair extending into the external iliac artery owing to a CIA aneurysm. The procedure was performed for a ruptured aneurysm in 22 (28%) patients. Eighty-one IIAs were intentionally covered. The median CIA diameter was 37 mm (range 20–90). The primary outcomes were the occurrence of type II endoleaks and the incidence of buttock claudication. Results: Five (6%) patients died within 30 days (4 with ruptured aneurysms and 1 elective case). Two type II endoleaks originating from a covered IIA were recorded; one required an endovascular intervention because of aneurysm growth. The other patient died of a rupture based on an additional type III endoleak. Mean follow-up was 37.6±26.3 months. Nineteen (26%) patients required a secondary intervention. Buttock claudication was reported in 21 (28%) of 74 patients and persisted after 1 year in 7. No severe ischemic complications as a result of IIA coverage were recorded, and no revascularization was required during follow-up. Conclusion: Treatment of CIA aneurysms by overstenting the IIA without preemptive coil embolization is safe and has a low risk of type II endoleak and aneurysm growth. Persisting buttock claudication is rare.
The Role of Protective Factors in the Predictive Accuracy of the Structured Assessment of Violence Risk in Youth (SAVRY)
Authors: Soderstrom Melanie F. P. , Childs Kristina K. , Frick Paul J.
Published: March 2019

The use of risk assessment instruments has become standard procedure in the juvenile justice system. Most empirical assessments of the predictive validity of these instruments concentrate on the ability of a total risk score, individual risk factors, or risk domains to predict negative juvenile outcomes but fail to consider the utility of the protective factors in influencing or moderating those risks. This study utilizes the Structured Assessment of Violence Risk in Youth to analyze the impact of protective factors on reoffending using a sample ( n = 460) of postadjudication juveniles in a southern state. The overall protective domain and two specific protective factors were related to reoffending in bivariate analyses. However, protective factors did not predict reoffending when controlling for risk domains. Rather, further analyses suggest that certain protective factors buffer the effects of some of the risk domains.
Poststroke Aphasia Rehabilitation: Why All Talk and No Action?
Authors: Wortman-Jutt Susan , Edwards Dylan
Published: March 2019

There is ample agreement in the scientific literature, across diverse areas of study, that suggests that language and movement are interrelated. In particular, it is widely held that the upper limb and hand play a key role in language use. Aphasia, a common, disabling language disorder frequently associated with stroke, requires new restorative methods. A combinatorial hand-arm-language paradigm that capitalizes on shared neural networks may therefore prove beneficial for aphasia recovery in stroke patients and requires further exploration.
Criminal justice in the middlebrow imagination: The punitive dimensions ofMaking a Murderer
Authors: LaChance Daniel , Kaplan Paul
Published: March 2019

Popular documentary representations of crime and punishment have traditionally tended to fall into two camps: programs that are critical of law enforcement agencies and those that are sympathetic to them. In this article, we show how programs that present themselves as critical of legal authorities can nonetheless reinforce the “law and order punitivism” that underlay the ratcheting up of harsh punishment in the late 20th century. In a case study of the popular documentary miniseries Making a Murderer, we show how this can happen when texts fetishize the question of a criminal defendant’s innocence, adopt a “good versus evil” approach to players in the criminal justice system, and perpetuate a procedural rather than substantive vision of justice. Arguments are supported by a close reading of Making a Murderer and illustrated by a line of discussion it inspired in an internet forum.
Atypical functional connectivity between the anterior cingulate cortex and other brain regions in a rat model of recurrent headache
Authors: Jia Zhihua , Chen Xiaoyan , Tang Wenjing , Zhao Dengfa , Yu Shengyuan
Published: March 2019

We explored the atypical functional connectivity between the anterior cingulate cortex and other brain areas in rats subjected to repeated meningeal nociception. The rat model was established by infusing an inflammatory soup through supradural catheters in conscious rats. Rats were subdivided according to the frequency of the inflammatory soup infusions. Functional connectivity analysis seeded on the anterior cingulate cortex was performed on rats 21 days after inflammatory soup infusion. Glyceryl trinitrate was injected following baseline scanning in the low-frequency inflammatory soup group and magnetic resonance imaging data were acquired 1 h after the injection. The rats exhibited nociceptive behavior after high-frequency inflammatory soup infusion. The anterior cingulate cortex showed increased functional connectivity with the cerebellum in the inflammatory soup groups. The medulla showed increased functional connectivity with the anterior cingulate cortex in the ictal period in the low-frequency inflammatory soup rats. Several areas showed increased functional connectivity with the anterior cingulate cortex in the high-frequency inflammatory soup group, including the pontine tegmentum, midbrain, thalamus, corpus callosum, hippocampus, and retrosplenial, visual, sensory, and motor cortices. This study indicated that the medulla participates in the early stage of a migraine attack and may be associated with the initiation of migraine. Sensitization of the trigeminal nociceptive pathway might contribute to the cutaneous allodynia seen in chronic migraine. Brain areas important for memory function may be related to the chronification of migraine. Electrophysiological studies should examine those migraine-related areas and provide new targets for migraine treatment and prevention.
Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy
Authors: Choi Sheu-Ran , Roh Dae-Hyun , Yoon Seo-Yeon , Choi Hoon-Seong , Kang Suk-Yun , Han Ho-Jae , Beitz Alvin James , Lee Jang-Hern
Published: March 2019

Spinal D-serine plays an important role in nociception via an increase in phosphorylation of the N-Methyl-D-aspartate (NMDA) receptor GluN1 subunit (pGluN1). However, the cellular mechanisms underlying this process have not been elucidated. Here, we investigate the possible role of neuronal nitric oxide synthase (nNOS) in the D-serine-induced potentiation of NMDA receptor function and the induction of neuropathic pain in a chronic constriction injury (CCI) model. Intrathecal administration of the serine racemase inhibitor, L-serine O-sulfate potassium salt (LSOS) or the D-serine degrading enzyme, D-amino acid oxidase (DAAO) on post-operative days 0–3 significantly reduced the CCI-induced increase in nitric oxide (NO) levels and nicotinamide adenine dinucleotide phosphate-diaphorase staining in lumbar dorsal horn neurons, as well as the CCI-induced decrease in phosphorylation (Ser847) of nNOS (pnNOS) on day 3 post-CCI surgery. LSOS or DAAO administration suppressed the CCI-induced development of mechanical allodynia and protein kinase C (PKC)-dependent (Ser896) phosphorylation of GluN1 on day 3 post-surgery, which were reversed by the co-administration of the NO donor, 3-morpholinosydnonimine hydrochloride (SIN-1). In naïve mice, exogenous D-serine increased NO levels via decreases in pnNOS. D-serine-induced increases in mechanical hypersensitivity, NO levels, PKC-dependent pGluN1, and NMDA-induced spontaneous nociception were reduced by pretreatment with the nNOS inhibitor, 7-nitroindazole or with the NMDA receptor antagonists, 7-chlorokynurenic acid and MK-801. Collectively, we show that spinal D-serine modulates nNOS activity and concomitant NO production leading to increases in PKC-dependent pGluN1 and ultimately contributing to the induction of mechanical allodynia following peripheral nerve injury.
Neurovascular disorders in pregnancy: A review
Authors: Roth Julie , Deck Gina
Published: March 2019

While rare, neurovascular disorders that occur in pregnant or postpartum women are associated with high morbidity and mortality, thus necessitating prompt identification and treatment. The most common symptoms include headache, focal neurological features, and seizures. Factors such as pregnancy-related hypercoagulability and hemodynamic changes put women at risk for neurovascular disorders in the third trimester and early postpartum period. The biggest risk factors for stroke in pregnancy are hypertension and the preeclampsia/eclampsia spectrum. This review outlines the diagnosis and treatment of pregnant and postpartum women with ischemic and hemorrhagic stroke, cerebral venous sinus thrombosis, posterior reversible encephalopathy syndrome, and reversible cerebral vasoconstriction syndrome.

Trial registration: Not applicable.
Constituents of Talisia nervosa with Potential Utility against Metabolic Syndrome
Authors: Vásquez Yelkaira , Zhao Jianping , Khan Shabana I. , Gupta Mahabir P. , Khan Ikhlas A.
Published: March 2019

This study is focused on the isolation and characterization of bioactive secondary metabolites from the ethanolic extract of stems of the Panamanian plant Talisia nervosa Radlk, through a series of target-based cellular assays related to the metabolic syndrome (MetS): a combination of type 2 Diabetes Mellitus (T2DM), hypercholesterolemia, inflammation, and obesity. Bioassay guided fractionation allowed the isolation of four known compounds: (-)-catechin (1), methyl gallate (2), ethyl gallate (3), and ß-D-glucopyranose,1,4,6-tris(3,4,5-trihydroxybenzoate) (4). This is the first report of (-)-catechin (1) and ß-D-glucopyranose,1,4,6-tris (3,4,5-trihydroxybenzoate) (4) from T. nervosa. Among the isolates, 1 activated PPARγ, but had no effect on PPARα. Compounds 2 -4 activated PPARα, PPARγ and LXR. Interestingly, 2 was stronger than 3 towards all three targets. Methyl gallate (2) showed the most potent effect toward both PPARα and PPARγ with an increase of 3.0 and 13-fold, respectively, while 4 was most potent in activating LXR with a fold induction of 5.3 at concentrations of 100 μg/mL. The nitric oxide (NO) production was reduced by compounds 2 and 3 with IC50 values of 7.0 and 7.5 μg/mL, respectively. ß-D-glucopyranose,1,4,6-tris (3,4,5-trihydroxybenzoate) 4) did not cause a significant increase in adipogenesis despite its strong PPARγ agonistic action (8 6-fold increase) and may represent a good candidate for the treatment of MetS without the undesirable side effect of weight gain.
Cladieunicellin T, a New Eunicellin-based Diterpenoid Produced by the Octocoral Cladiella sp
Authors: Zhang Zhi-Jun , Peng Bo-Rong , Hu Chiung-Chih , Lin Nai-Cheng , Yao Jia-Wen , Lu Mei-Chin , Wen Zhi-Hong , Wu Yang-Chang , Sung Ping-Jyun
Published: March 2019

A new eunicellin-based diterpenoid, cladieunicellin T (1), was produced by an octocoral identified as Cladiella sp. The structure of eunicellin 1 was established by extensive spectroscopic methods.
Synthesis, Structure and Antimicrobial Activity of Novel Metabolites from a Marine Actinomycete in Vietnam's East Sea
Authors: Cao Duc-Tuan , Nguyen Thuy-Linh , Tran Van-Hieu , Doan-Thi-Mai Huong , Vu-Thi Quyen , Nguyen Mai-Anh , Le-Thi Hong-Minh , Chau Van-Minh , Pham Van-Cuong
Published: March 2019

A naturally new ester, 2,4-dichlorophenyl 2,4-dichloro benzoate (1) and a new compound, 4,5-dihydroxy-7-methylphthalide (2), along with eight known compounds were isolated from the fermentation broth of the marine-derived actinomycete Streptomyces sp. (strain G212). The structures of these compounds were established by their spectral data analysis, including MS, and 2D-NMR. To confirm the structures of the two new compounds 1 and 2, their total syntheses were achieved. These syntheses also allow obtaining enough quantities of 1 and 2 for their biological screening. The isolated compounds and synthetic samples were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Except for 8 and 10, the remaining compounds were active against at least one tested microbial strain with the MIC values in range of 32-256 μg/mL. Compounds 5, 6, 17 and 2a were found to have a broad-spectrum of antimicrobial activity.
Chemical Constituents from the Fungus Antrodia cinnamomea
Authors: Wu Ming-Der , Cheng Ming-Jen , Chen Yen-Lin , Hsun-Hsuo-Chang  , Kuo Yueh-Hsiung , Lin Chih-Chuan , Wu Ho-Cheng
Published: March 2019

A new benzenoid, 4-methoxy-7-methylbenzo[ d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2-methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1–4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8–8.7 μM in vitro.
Intermittent Parathyroid Hormone [1-34] Augments Chondrogenesis of the Mandibular Condylar Cartilage of the Temporomandibular Joint
Authors: Dutra Eliane H. , O’Brien Mara H. , Chen Po-Jung , Wei Mei , Yadav Sumit
Published: March 2019

Objective

To characterize the long-term effects of intermittent parathyroid hormone (I-PTH) on the mandibular condylar cartilage (MCC) and subchondral bone of the temporomandibular joint, in vivo and in vitro.

Materials and Methods

For the in vivo experiments, sixteen 10-week-old mice were divided into 2 groups: (1) I-PTH ( n = 8)—subcutaneous daily injection of PTH; (2) control group ( n = 8)—subcutaneous daily injection of saline solution. Experiments were carried out for 4 weeks. Mice were injected with calcein, alizarin complexone, and cell proliferation marker before euthanasia. For the in vitro experiments, primary chondrocyte cultures from the MCC of eight 10-week-old mice were treated with I-PTH for 14 days.

Results

There was a significant increase in bone volume, tissue density, mineral deposition, osteoclastic activity, cell proliferation in the cartilage, and cartilage thickness in the I-PTH-treated mice when compared with the control group. In addition, immunohistochemistry in cartilage revealed that I-PTH administration led to an increase in expression of vascular endothelial growth factor and to a decreased expression of sclerostin, matrix metallopeptidase 13, and aggreganase-1 (ADAM-TS4). Quantitative polymerase chain reaction analysis of the I-PTH-treated chondrocytes revealed significantly decreased relative expression of collagen type X ( Col10a1), alkaline phosphatase ( Alp), and Indian Hedgehog ( Ihh) and remarkable increased expression of Sox9, fibroblast growth factor 2 ( Fgf2), and proteoglycan 4 ( Prg4).

Conclusion

I-PTH administration causes anabolic effects at the subchondral region of the mandibular condyle while triggers anabolic and protective effects at the MCC.
Brand Authenticity and Brand Attachment: How Online Communities Built on Social Networking Vehicles Moderate the Consumers’ Brand Attachment
Authors: Arya Vikas , Verma Hemraj , Sethi Deepa , Agarwal Rajat
Published: March 2019

The purpose of this article is to analyse consumers’ attachment behaviour to a particular brand due to its perceived authenticity. The study aims to identify the relationship of brand authenticity with the consumers’ brand attachment behaviour in the presence of online brand communities (OBCs) built on social networking vehicles. The descriptive research was conducted on 354 Indian respondents and the findings were then analysed using SPSS 22.0 and AMOS 24.0. The analysis revealed that consumers’ brand attachment is fairly very high when the brand is perceived as genuine and authentic. Further, the relationship between brand authenticity and consumers’ brand attachment behaviour is moderated by the presence of OBCs. Therefore, companies should be attentive towards developing an authentic product in order to catch the consumers’ buying inclination and should consider to have their presence on communities and forums over social networking sites. This article is novel in the sense that it provides an understanding about the impact of perceived brand authenticity on brand attachment behaviour. Authenticity of the product articulates the consumers’ desire to discover meaning and purpose in their lives and is a process of living out one’s set of strongly held personal attachment with the brand.
Sexual Dysfunction in Aging Males: A Review
Authors: Priyadarshi Shivam
Published: March 2019

Assaults on sexuality in aging males result from changes in sexual physiology, psychosocial changes, irregular sexual activity, androgen deficiency, cardiovascular disease and risk factors, and lower urinary tract symptoms. Chronic illness, side effects of medications, and different kinds of surgery which the male may undergo during the aging process may all have its deleterious effects on sexual functions.

A healthy sexual attitude combined with lifestyle changes and addressing the physical problems provide a greater potential for enjoying a more fulfilled sexual life as one ages.
The Impact of Executive Coaching on Project Managers’ Personal Competencies
Authors: Ballesteros-Sánchez Luis , Ortiz-Marcos Isabel , Rodríguez-Rivero Rocío
Published: March 2019

Personal competencies have been shown to be increasingly reliable predictors of successful project managers. This research studies whether executive coaching is effective in strengthening personal competencies in the project management field. An experiment with 30 project managers and 30 observers has been conducted to determine, by means of a quantitative and qualitative approach, the impact of coaching on different competencies based on the Project Manager Competency Development Framework – Third Edition (Project Management Institute, 2017a). The conclusions reveal interesting insights, such as the finding that executive coaching has the greatest impact on behaviors related to leading, managing, and finding strategies for coping with challenging situations.
NPM1 mutations define a specific subgroup of MDS and MDS/MPN patients with favorable outcomes with intensive chemotherapy
Authors: Montalban-Bravo Guillermo , Kanagal-Shamanna Rashmi , Sasaki Koji , Patel Keyur , Ganan-Gomez Irene , Jabbour Elias , Kadia Tapan , Ravandi Farhad , DiNardo Courtney , Borthakur Gautham , Takahashi Koichi , Konopleva Marina , Komrokji Rami S. , DeZern Amy , Kuzmanovic Teodora , Maciejewski Jaroslaw , Pierce Sherry , Colla Simona , Sekeres Mikkael A. , Kantarjian Hagop , Bueso-Ramos Carlos , Garcia-Manero Guillermo
Published: March 2019

Nucleophosmin (NPM1) mutations are common in acute myeloid leukemia and are associated with high remission rates and prolonged survival with intensive chemotherapy. NPM1 mutations are rare in myelodysplastic syndromes (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and the clinical outcomes of these patients, when treated with intensive chemotherapy, are unknown. We retrospectively evaluated the clinicopathologic characteristics and the impact of therapy in 31 patients with MDS or MDS/MPN and NPM1 mutations. Next-generation sequencing was performed at diagnosis in 22 patients. Median age was 62 years (range, 19-86). Twenty-four patients (77%) had normal karyotype, and all had multilineage dysplasia. Most patients could be classified as MDS with excess blasts (19/31, 61%). NPM1 mutations were detected at a median allele frequency of 0.38 (range, 0.09-0.49). Mutation burden did not correlate with bone marrow blast frequency, and its clearance seemed to be associated with decreased morphologic dysplasia. Ten of the 31 patients (32%) received cytotoxic chemotherapy, 20 (65%) hypomethylating agents, and 1 (4%) lenalidomide. Sequential sequencing was available in 16 (52%) patients, and mutation burden correlated with disease status and response to therapy. Patients treated with chemotherapy had higher complete response rates (90% vs 28%, P = .004), longer median progression-free survival (not reached vs 7.5 months, P = .023), and overall survival (not reached vs 16 months, P = .047). Intensive chemotherapy and allogeneic stem cell transplantation (SCT) may be associated with improved clinical outcomes in patients with NPM1-mutated MDS or MDS/MPN who are candidates for this form of therapy.
Effect of Muscle–Tendon Unit Length on Child–Adult Difference in Neuromuscular Fatigue
Authors: PIPONNIER ENZO , MARTIN VINCENT , CHALCHAT EMERIC , BONTEMPS BASTIEN , JULIAN VALÉRIE , BOCOCK OLIVIA , DUCLOS MARTINE , RATEL SÉBASTIEN
Published: March 2019

Purpose

The purpose of this study was to compare the development and etiology of neuromuscular fatigue of the knee extensor muscles at different muscle–tendon unit (MTU) lengths during repeated maximal voluntary isometric contractions (MVIC) between boys and men.

Methods

Twenty-two prepubertal boys (9–11 yr) and 22 men (18–30 yr) performed three knee extensor fatigue protocols at short (SHORT), optimal (OPT), and long (LONG) MTU lengths, consisting of repeating 5-s MVIC interspersed with 5-s passive recovery periods until torque reached 60% of the initial MVIC torque. The etiology of neuromuscular fatigue was identified using noninvasive methods such as surface electromyography, near-infrared spectroscopy, magnetic nerve stimulation and twitch interpolation technique.

Results

The number of repetitions was significantly lower in men at OPT (14.8 ± 3.2) and LONG (15.8 ± 5.8) than boys (39.7 ± 18.4 and 29.5 ± 10.2, respectively; P < 0.001), whereas no difference was found at SHORT between both age groups (boys, 33.7 ± 15.4; men, 40.9 ± 14.2). At OPT and LONG boys showed a lower reduction in the single potentiated twitch (Qtwpot) and a greater decrease in the voluntary activation level than men. At SHORT, both populations displayed a moderate Qtwpot decrement and a significant voluntary activation reduction (P < 0.001). The differences in maximal torque between boys and men were almost twice greater at OPT (223.9 N·m) than at SHORT (123.3 N·m) and LONG (136.5 N·m).

Conclusions

The differences in neuromuscular fatigue between children and adults are dependent on MTU length. Differences in maximal torque could underpin differences in neuromuscular fatigue between children and adults at OPT and SHORT. However, at LONG these differences do not seem to be explained by differences in maximal torque. The origins of this specific effect of MTU length remain to be determined.
Δύο σπάνιαι περιπτώσεις χρονίας κλειστής μάλιος διαγνωσθείσαι ορολογικώς δια της μεθόδου της 'Εκτροπής του Συμπληρώματος
Authors: ΦΡΑΓΚΟΠΟΥΛΟΣ Α. Γ. , ΓΙΑΝΝΟΠΟΥΛΟΣ Α.
Published: March 2019

NO ABSTRACT AVAILABLE
Η ΜΕΤΑΓΓΙΣΙΣ ΑΙΜΑΤΟΣ ΠΡΟΣ ΠΡΟΛΗΨΙΝ ΚΑΙ ΘΕΡΑΠΕΙΑΝ ΤΩΝ ΠΑΘΗΣΕΩΝ (ΚΟΛΙΒΑΚΙΛΛΩΣΕΩΣ) ΤΩΝ ΝΕΟΓΕΝΝΗΤΩΝ ΜΟΣΧΩΝ ( Î )
Authors: ΣΕΪΤΑΡΙΔΗΣ Κ. , ΚΑΡΑΠΙΠΕΡΗΣ Α.
Published: March 2019

NO ABSTRACT AVAILABLE
ΤΟ ΠΡΟΒΛΗΜΑ ΤΗΣ ΚΑΤΑΠΟΛΕΜΗΣΕΩΣ ΤΗΣ ΦΥΜΑΤΙΩΣΕΩΣ ΤΩΝ ΒΟΟΕΙΔΩΝ-ΜΕΘΟΔΟΙ ΚΑΙ ΜΕΣΑ ΕΚΡΙΖΩΣΕΩΣ ΤΗΣ ΝΟΣΟΥ
Authors: ΜΕΝΑΣΕ Ι. , ΜΑΛΛΙΑΡΗΣ Σ. , ΣΕΙΜΕΝΗΣ Α.
Published: March 2019

NO ABSTRACT AVAILABLE
Η ΘΕΙΟ - 2 - 2' ( ΔΙΧΛΩΡΟ - 4 - 6 - ΦΑΙΝΟΛΗ ) ΕΙΣ ΤΗΝ ΘΕΡΑΠΕΙΑΝ ΤΩΝ ΕΚ MONIEZIA SP. ΠΡΟΣΒΕΒΛΗΜΕΝΩΝ ΑΜΝΩΝ
Authors: ΒΑΣΑΛΟΣ Μ. , ΠΑΠΑΔΟΠΟΥΛΟΣ Π. , ΛΙΟΥΠΗΣ Σ. , ΑΝΑΓΝΩΣΤΟΥ Λ. , ΓΚΡΙΤΖΑΛΑΣ Α.
Published: March 2019

NO ABSTRACT AVAILABLE
ΤΟ ΠΡΟΒΛΗΜΑ TΩN ΧΡΟΝΙΩΝ ΛΑΝΘΑΝΟΥΣΩΝ ΜΑΣΤΙΤΙΔΩΝ ΚΑΙ Ο ΕΛΕΓΧΟΣ ΑΥΤΩΝ
Authors: ΡΩΣΣΗΣ Θ. Ι.
Published: March 2019

NO ABSTRACT AVAILABLE
ΕΡΕΥΝΑ ΕΠΙ ΤΗΣ ΥΠΑΡΞΕΩΣ ΕΞ0ΥΔΕΤΕΡΩΤΙΚΩΝ ΤΟΥ ΙΟΥ TESGHEN ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΤΟΣ ΤΟΥ ΟΡΡΟΥ ΑΙΜΑΤΟΣ ΤΩΝ ΧΟΙΡΩΝ ΕΝ ΕΛΛΑΔΙ
Authors: ΣΤΟΦΟΡΟΣ Ε. Ν. , ΔΡΑΓΩΝΑΣ Π. Ν. , ΜΑΣΤΡΟΓΙΑΝΝΗ-ΚΟΡΚΟΛΟΠΟΥΛΟΥ Μ.
Published: March 2019

NO ABSTRACT AVAILABLE
Η ΔΥΣΕΝΤΕΡΙΑ TΩN XOIPΩN (Πρώται παρατηρήσεις èv Ελλάδι)
Authors: ΣΤΟΦΟΡΟΣ Ε. Ν. , ΦΡΑΓΚΟΠΟΥΛΟΣ Α. Γ.
Published: March 2019

NO ABSTRACT AVAILABLE
Η ΜΕΘΥΡΙΑΙΝΗ «2 - (2 - methoxy - ethyl) pyridine» ΕΙΣ ΤΗΝ ΚΑΤΑΠΟΛΕΜΗΣΙΝ ΤΗΣ ΚΑΠΙΑΛΑΡΙΑΣΕΩΣ TΩN ΠΤΗΝΩΝ
Authors: ΒΑΣΑΛΟΣ Μ.
Published: March 2019

NO ABSTRACT AVAILABLE
TRIALS OF FOOT-AND-MOUTH DISEASE VACCINATION AND POTENCY TESTS IN GOATS
Authors: ΠΑΠΠΟΥΣ Χ. , ΜΠΡΟΒΑΣ Δ. , ΚΑΡΑΒΑΛΑΚΗΣ Ι. , Souyioultzoglou Irakleitos
Published: March 2019

4 batches of Foot - and - Mouth Disease (FMD) vaccine were assayed in adult goats, from local breedings, serologically positive for Brucella. These goats were to be slaughtered, in accordance with an eradication program. The viremia was checked by using the plaque forming unit (PFU) and the cytopathic effect methods, every 24 hours for 3 days post—inoculation and it has been found that it is variable both in intensity and duration. In the controls the viremia was detected in 4/5 to 5/5 of the animals whereas in the vaccinated animals it dependent on the dose of vaccine and on virus units (104 to 105 ) used, for the infection. The neutralizing antibody titres after vaccination were generally lower than those observed in cattle and sheep and they varied significantly among the animals vaccinated with the same dose. This is in accordance with the findings of a preliminary work where the titres were also low and they were then attributed to the young age of the animals used. The titres were about the same in the groups vaccinated with undiluted or diluted 1/4 vaccine and lower in those vaccinated with 1/16 of the normal dose. The revaccination carried out 3 weeks after the first vaccination increases the antibody titre as well as the resistance of animals to challenge. It was observed that an increase of the antibody titres resulted in a decrease of the percentage of animals positive to viremia but this percentage was still significant even in goats with high antibody titres.As regards to the generalization of the disease it was not so frequent when the infection was made with 104 to 105 DL^ FMD virus and it mostly affected the animals partially, on 1, 2 or 3 feet. With the use of higher doses of virus (10-6 · 50) the resistance of the animals appeared to be overcome by the infection. Sometimes, despite the high titres (1,87 and 1,95) of antibodies, viremia occured whereas in some animals with generalized lesions the viremia was not detected. This last fact may be due to the temporariness of the viremia or its eventual late appearance. As a conclusion we consider that viremia detection may be used for estimating the potency of FMD vaccine in goats, when the animals are infected with 104 to 105 DL5 0 FMD virus.The generalization of the disease must also be taken into account in cases that viremia is not detected. So the 4 vaccine batches, of a protective dose 50% for guinea pigs {0.25, (0.14, 0.12 and 0.48 ml, when tested on goats, their protective dose 50% was respectively 0.50, <1 , 1.25 and 0.47ml. If both viremia and generalization are taken into account, then the protective dose 50% for goats were respectively 0.50, <1 , 1.25 and 0.96 ml.
STUDY ON THE COTTONSEED MEAL
Authors: ΕΥΣΤΑΘΙΟΥ Λ.
Published: March 2019

NO ABSTRACT AVAILABLE
CONTRIBUTION TO THE STUDY OF THE HYGENIC CONDITION OF GREEK CHEESES
Authors: ΣΚΟΥΝΤΖΟΣ Κ. , ΠΑΠΑΔΙΑ Α. , ΓΙΩΤΗ Α.
Published: March 2019

801 samples of various types of Greek cheese (fêta, kefalotyrion, gruyère and kasserion) obtained from the Attican area were examined. The contained numbers of coliforms, intestinal colibacilli and pathogenic staphylococci were determined, and the presence of Salmoncllae was investigated. It was revealed that 22.11%, 28.88%, 11.48% and 0.94% of feta, kefalotyrion, gruyère and kasserion samples, respectively, contained more than 100 intestinal colibacilli per gram sample; furthermore, 19.84%, 22.21 %, 10.56% and 0.95% of the same samples contained more than 1.000 coliforms per gram sample. In 1.99% and 0.52% of feta and kasserion samples, respectively, the presence of pathogenic staphylococci was established, whereas SQ .lmonellae were not found in any of the cheese samples examined. The establishment of criteria for the definition of the hygenic condition of Greek cheeses, as well as for their uniform testing technique is proposed.
DNA interference by a mesophilic Argonaute protein, CbcAgo
Authors: García-Quintans Nieves , Bowden Laurie , Berenguer José , Mencía Mario
Published: March 2019

Background: The search for putative enzymes that can facilitate gene editing has recently focused its attention on Argonaute proteins from prokaryotes (pAgos). Though they are structural homologues of human Argonaute protein, which uses RNA guides to interfere with RNA targets, pAgos use ssDNA guides to identify and, in many cases, cut a complementary DNA target. Thermophilic pAgos from Thermus thermophilus, Pyrococcus furiosus and Methanocaldococcus jasmanii have been identified and thoroughly studied, but their thermoactivity makes them of little use in mesophilic systems such as mammalian cells.

Methods: Here we search for and identify CbcAgo, a prokaryotic Argonaute protein from a mesophilic bacterium, and characterize in vitro its DNA interference activity.

Results: CbcAgo efficiently uses 5’P-ssDNA guides as small as 11-mers to cut ssDNA targets, requires divalent cations (preferentially, Mn2+) and has a maximum activity between 37 and 42 °C, remaining active up to 55 °C. Nicking activity on supercoiled dsDNA was shown. However, no efficient double-strand breaking activity could be demonstrated.

Conclusions: CbcAgo can use gDNA guides as small as 11 nucleotides long to cut complementary ssDNA targets at 37ºC, making it a promising starting point for the development of new gene editing tools  for mammalian cells.
Case Report: Presentation of an unusual cause of carpal tunnel syndrome with accompanying literature review
Authors: Patiniott Paul , Herath Matheesha , Riddell Peter
Published: March 2019

Background: Carpal tunnel syndrome (CTS) is a condition seen commonly in clinical practice; high-flow arteriovenous malformations (AVM) can be a rare but important cause.

Case Report: We discuss a case of a patient who had developed left CTS in the fifth decade of life as the result of a progressively enlarging congenital peripheral AVM affecting his left upper limb. This case illustrates the clinical challenges encountered in the surgical and interventional management of this complex issue.

Discussion:High-flow AVMs affecting the extremities may be comprised of a convoluted network of vessels in high-flow, low-resistance systems that often recur despite intervention.

Conclusion: Peripheral AVM affecting the hand can be a rare and therapeutically challenging cause of carpal tunnel syndrome that warrants multidisciplinary team discussion.
Meteor trail drift research based on baseline observations
Authors: Иванов Кирилл , Ivanov Kirill , Комарова Евгения , Komarova Evgeniya , Васильев Роман , Vasilyev Roman , Еселевич Максим , Eselevich Maxim , Михалев Александр , Mikhalev Aleksandr
Published: March 2019

We analyze the results of a rare long-lived quasisymmetric ellipsoidal-annular meteor trail recorded on November 18, 2017 by two optical all-sky cameras, spaced at a distance of 150 km. The analysis is based on astrometric processing results with the use of baseline measurement methods. We determine spatial-kinematic characteristics of the meteor trail, and find features of its evolution. The ignition and extinction heights of the meteor were in the range 75–120 km. The estimate of the meteor brightness gives the absolute magnitude value of about –7.3m. It is shown that the distribution of all parts of the long-lived meteor trail occurs in the same plane at a height of ~90 km at a speed of ~320 m/s and, apparently, cannot be a consequence of an air mass movement. The total time of the meteor trail observation was more than 30 min. We offer possible explanations for the results obtained in the context of upper atmosphere processes.
Investigating seasonal features of electron temperature enhancement regions in the subauroral ionosphere
Authors: Гололобов Артем , Gololobov Artem , Голиков Иннокентий , Golikov Innokentiy
Published: March 2019

The electron temperature enhancement is known to occur in the main ionospheric trough during geomagnetic disturbances. In this paper, we study fea-tures of the formation of the electron temperature (Te) enhancement in the subauroral ionosphere by comparing results of the numerical simulation with measurements of Te onboard the CHAMP satellite under moderate geomagnetic activity conditions. It is shown that depending on the terminator position and universal time (UT), the location of the enhanced Te regions in the subauroral ionosphere varies in different seasons. So, in winter ring-shaped and sickle-shaped regions can be formed, whereas during the equinox and summer periods sickle-shaped regions of different lengths and clarity are generally observed.
Effectiveness of Product Recommendations Under Time and Crowd Pressures
Authors: Kawaguchi Kohei , Uetake Kosuke , Watanabe Yasutora
Published: March 2019

This paper studies how time pressure and crowd pressure affect the effectiveness of product recommendations using the experimental data.
ILHAS DE CALOR SUPERFICIAIS: FREQUÊNCIA DA INTENSIDADE E VARIABILIDADE ESPACIAL EM CIDADE DE CLIMA TROPICAL CONTINENTAL
Authors: Amorim Margarete Cristiane De Costa Trindade
Published: March 2019

Este artigo teve como objetivo analisar a distribuição espacial das temperaturas dos alvos e a frequência de intensidades das ilhas de calor superficiais em áreas com diferentes características de uso da terra, de cobertura vegetal, de densidade de edificação e de padrão construtivo de habitação, em Presidente Prudente/SP. Os procedimentos adotados consistiram na utilização de 24 imagens do satélite Landsat 8, banda 10, disponíveis e sem cobertura de nuvens entre fevereiro de 2013 e janeiro de 2016. Os resultados mostraram que a maior frequência de altas intensidades de ilhas de calor superficiais foi registrada em conjunto habitacional de baixo padrão construtivo, seguido por bairro de médio padrão construtivo. As áreas com menor densidade construtiva e presença de solos permeáveis com cobertura vegetal rasteira e arbórea foram as que apresentaram maior frequência de baixas intensidades de ilhas de calor superficiais. A variabilidade espacial das temperaturas das superfícies no ambiente urbano e rural próximo resulta das características físicas dos alvos (tipos de materiais construtivos, impermeabilização do solo, densidade de construções e de vegetação). Estas características, decorrentes do processo de urbanização, podem contribuir para que a população mais pobre e, portanto, mais vulnerável, seja mais suscetível a situações de desconforto térmico e sujeitas a problemas de saúde.
Enteritis in weaned cattle: an overview of causes
Authors: Mueller Karin
Published: March 2019

While calf diarrhoea may receive more attention, enteritis in young adult and mature cattle is common and has a variety of causes. This review provides an overview of such causes and outlines how to approach diagnosis in the weaned animal with diarrhoea.
THE DEVELOPMENT OF TECHNOLOGY FOR OBTAINING OF TENESTROL SUBSTANCE OF ESTROGENIC AC-TION FROM THE AERIAL PARTS OF FERULA TENUISECTA
Authors: Маматханова (Mamatkhanova) Мунирахон (Munirakhon) Ахматхон кизи (Ahmatkhon kizi) , Халилов (Khalilov) Равшанжон (Ravshanzhon) Муратджанович (Muratdzhanovich) , Котенко (Kotenko) Любовь (Lyubov') Дмитриевна (Dmitrievna) , Маматханов (Mamatkhanov) Ахматхон (Ahmatkhon) Умарханович (Umaralievich)
Published: March 2019

Extraction of the sum of esters of the sesquiterpene alcohols from the aerial part of Ferula tenuisecta and purification of obtained extract were studied, allowing in following to get the final substance without green coloration. It was determined the optimum adsorbent – actuated coal and its amount for removing the green coloration of water-alcohol extract from used raw materials. It was found that for the purification of the bottoms of water-alcohol extract, five-fold treatment with extractive petrol in a volume ratio of water solution – solvent 2:1 is necessary, and for extraction esters from a purified water solution – three-fold extraction with ethyl acetate in a volume ratio of water solution – solvent 2:1.

It was used a filler to effective drying the substance of Tenestrol. The microcrystalline cellulose in a weight ratio from 1:8 to 1:10 to the raw material was chosen as the optimum filler.

Technology for obtain of substance of esters of sesquiterpene alcohols with estrogenic action from the aerial part of Ferula tenuisecta was developed and called “Tenestrol”. From this technology substance "Tenestrol" with yield of 3.8% by weight of the raw material is obtained, which contains not less 20% of the esters.
PERSPECTIVES OF WOOD-GREENERY BIOTECHNOLOGY ENRICHMENT WITH L-ARGININE AND INHIBITORS OF ITS CATABOLISM
Authors: Робонен (Robonen) Елена (Elena) Вильямовна (Vil'yamovna) , Чернобровкина (Chernobrovkina) Надежда (Nadezhda) Петровна (Petrovna) , Чернышенко (Chernyshenko) Оксана (Oksana) Васильевна (Vasil'evna) , Зайцева (Zaytseva) Мария (Mariya) Игоревна (Igorevna) , Унжаков (Unzhakov) Алексей (Aleksey) Рудольфович (Rudol'fovich) , Егорова (Egorova) Анастасия (Anastasiya) Васильевна (Vasil'evna)
Published: March 2019

A promising source of L-arginine, as well as natural inhibitors of its catabolism enzymes, are plants. Free amino acids constitute a significant part of the water-soluble fraction of woody greenery of coniferous plants, including L-arginine. The biotechnology of L-arginine enrichment of coniferous woody greenery is developed by regulating nitrogen and boron support. The fact of a multiple increase in the pool of free L-arginine in needles suggests an increase in the level of enzyme inhibitors of its catabolism. Coniferous greens contain guanidine compounds, which are therapeutic agents for controlling the activity of nitric oxide synthases. L-arginine, one of the most universal amino acids in the metabolism of the animal body, in mammals is classified as a conditionally essential amino acid. The imbalance of the activities of the arginic and NO-synthase catabolism pathways of arginine, competing for the substrate, can lead to pathological consequences for the organism. Activation of inducible NO synthase or arginase reflects the type of inflammatory response in the development of specific diseases. In their treatment, the effectors controlling the activity of catabolism enzymes are considered as targets for pharmacological action. Examples of the use in folk medicine of extracts from some species of gymnosperms are given in the works of ethnomedical orientation. Analysis of the current state of studies of the metabolism of L-arginine in living organisms and its features in coniferous plants was carried out for the scientific substantiation of the prospects of obtaining enzymes for its metabolism of woody greens enriched with L-arginine and effector enzymes.
INVESTIGATION AND OPTIMIZATION OF COMPLEXATION OF COBALT IONS WITH DIHYDROQUERCETIN IN AQUEOUS SOLUTIONS
Authors: Столповская (Stolpovskaya) Елена (Elena) Владимировна (Vladimirovna) , Трофимова (Trofimova) Наталья (Natal'ya) Николаевна (Nikolaevna) , Бабкин (Babkin) Василий (Vasiliy) Анатольевич (Anatol'evich) , Житов (Zhitov) Роман (Roman) Георгиевич (Georgievich)
Published: March 2019

We continue to study the reactions of complexation of biogenic metal ions with flavonoid dihydroquercetin (DHQ). The interaction of Co2+ ions with DHQ in aqueous solutions has been studied. It is established that complexes with different stoichiometry are formed at different pH values of the solution. Changing the pH of the solution from 6.0 to 7.0 leads to the formation of compounds 1–3 with a metal: flavonoid ligand (Met: L) ratio from 1: 2 at pH 6.0 (1) via 2: 3 at pH 6.4 -6.7 (2) to 1: 1 at pH 6.8-7.0 (3). Using the method of thermogravimetry with elemental analysis data, the most probable composition of compounds was established with the determination of the amount of bound water: [CoL2(H2O)4] for 1, [Co2L3(OH)(H2O)4] for 2 and [CoL(OH)(H2O)2] for 3. The conditions for the complexation of Co2+ ions with dihydroquercetin in aqueous solutions to form compound 2, optimized for the yield of the product, are proposed. pH of the solution is 6.7, the reaction time is 15 minutes, the temperature of the reaction solution is 90 °C, molar ratio of the initial reagents DHQ:Co2+ is 1: 1.5, initial concentrations are 0,020 M DHQ and 0,030 M Co2+, the source of Co2+ is CoSO4∙7H2O. The yield of the product is 81.8 %.
PLASMA MODIFICATION OF POLYVINYL ALCOHOL MICROFIBERS TO IMPROVE COHESION WITH CEMENT MATRIX
Authors: Ďureje Jakub , Prošek Zdeněk , Trejbal Jan , Tesárek Pavel
Published: March 2019

The article describes plasma modifications of the surface of polyvinyl alcohol (PVA) microfibers using oxygen and hydrogen plasma in order to improve the properties of the composite material containing modified microfibers, cement and recyclate. Five different modification times 30, 60, 120, 240 and 480 seconds were applied. Changes on fiber surface were detected by SEM analysis, packed cell wettability measurement, and weight loss during modification. The selected durations of plasma treatment were chosen to produce test samples on which the modulus of elasticity was continuously measured and then bending and compression tests were performed. The measured values were compared with the reference samples. Oxygen modified fibers behavior is more hydrophilic compare with reference fibers, but hydrogen modified fibres behave more hydrophobic than reference fibers.
GLASS WASTE POWDER UTILIZATION IN HIGH PERFORMANCE CONCRETE
Authors: Mariaková Diana , Vlach Tomáš , Pavlů Tereza
Published: March 2019

This paper deals with investigation of high-performance concrete (HPC) with full replacement of the silica powder by the waste glass powder. The silica powder was replaced by two types of the waste glass powder, originated from different sources (waste glass powder from grinding jewelry and milling of municipal waste glass). The properties of the waste glass powder were examined and compared with the silica powder. The mechanical and durability properties of three HPC mixtures were experimentally verified. The bulk density, flexural strength, and compressive strength were tested on beams 40 × 40 × 160mm at age 28 and 60 days and after 0, 25, 50, 75 and 100 freeze-thaw cycles. There were observed slightly worse properties of mixtures with the waste glass powder in comparison with reference HPC.
Promoting intercultural awareness among European university students via pre-mobility virtual exchanges
Authors: Batardière Marie-Thérèse , Giralt Marta , Jeanneau Catherine , Le-Baron-Earle Florence , O’Regan Veronica
Published: March 2019

For more than 30 years, the Erasmus programme has given thousands of higher education students throughout Europe the chance to live and study abroad. For many, this sojourn in a foreign country is an extraordinary learning experience which enriches their language and (inter)cultural learning process. However, for others, this opportunity is undermined by cultural shock or lack of preparation...
Step-based evolution support among networked production automation systems
Authors: Haubeck Christopher , Bornholdt Heiko , Lamersdorf Winfried , Chakraborty Abhishek , Fay Alexander
Published: March 2019

Production systems are no longer rigid, unyielding, and isolated systems anymore. They are rather interconnected cyber-physical systems with an evolution process that needs to be supported. To enable reusability in evolution, a change-first cooperative support is proposed that relies on model-based evolution steps. The approach establishes a network-wide evolution process in a peer-to-peer networked community. Thus, moving towards decentralised marketplaces for evolution steps.
Image schemas, mimetic schemas and children's gestures
Authors: Zlatev Jordan
Published: March 2019

Mimetic schemas, unlike the popular cognitive linguistic notion of image schemas, have been characterized in earlier work as explicitly representational, bodily structures arising from imitation of culture-specific practical actions (Zlatev 2005, 2007a, 2007b). We performed an analysis of the gestures of three Swedish and three Thai children at the age of 18, 22 and 26 months in episodes of natural interaction with caregivers and siblings in order to analyze the hypothesis that iconic gestures emerge as mimetic schemas. In accordance with this hypothesis, we predicted that the children's first iconic gestures would be (a) intermediately specific, (b) culture-typical, (c) falling in a set of recurrent types, (d) predominantly enacted from a first-person perspective (1pp) rather than performed from a third-person perspective (3pp), with (e) 3pp gestures being more dependent on direct imitation than 1pp gestures and (f) more often co-occurring with speech. All specific predictions but the last were confirmed, and differences were found between the children's iconic gestures on the one side and their deictic and emblematic gestures on the other. Thus, the study both confirms earlier conjectures that mimetic schemas “ground” both gesture and speech and implies the need to qualify these proposals, limiting the link between mimetic schemas and gestures to the iconic category.
Stability of an AQCQ functional equation in non-Archimedean (n, β)-normed spaces
Authors: Liu Yachai , Yang Xiuzhong , Liu Guofen
Published: March 2019

In this paper, we adopt direct method to prove the Hyers-Ulam-Rassias stability of an additivequadratic-cubic-quartic functional equation

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Serum inflammatory cytokines comparison in gastric cancer therapy
Authors: Zhang Li , Ren Lehao , Shan Keshu , Guo Xiaobo , Wang Jinshen , Cui Bin , An Jie
Published: March 2019

To compare serum inflammatory cytokines between laparoscopic-assisted and open radical gastrectomy in the perioperative period, 80 cases of advanced gastric cancer were chosen for the study. They were divided into laparoscopy group (40 cases) and abdominal open surgery group (40 cases), performed laparoscopic-assisted radical gastrostomy and conventional open radical gastrectomy, respectively. Serum Heme oxygenase-1 (HO-1), TNF-α, IL-6 and CRP were measured by ELISA on preoperative day 1, post-operative day 1 and post-operative day3. Serum HO-1, TNF-α, IL-6 and CRP had no significant difference between the laparoscopy group and the open group on pre-operative day 1. Serum HO-1, IL-6 and CRP of the laparoscopy group were significantly lower than that of the open group on post-operative day 1 and day 3 except for Serum TNF-α which had no significant difference. Laparoscopic-assisted radical gastrectomy was minimally invasive compared with conventional open radical gastrectomy in advanced gastric cancer patients.