bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating video tracking and GPS to quantify accelerations and decelerations in elite soccer
Authors: Pons Eduard , García-Calvo Tomás , Cos Francesc , Resta Ricardo , Blanco Hugo , López del Campo Roberto , Díaz-García Jesús , Pulido-González Juan José
Published: September 2021

The aim of this study was to analyze the degree of agreement comparing number and distance covered in different acceleration and deceleration sections registered by a video tracking system (MEDIACOACH) and a GPS device (WIMU PRO) during official competition. Data from a Spanish professional club were registered over the course of a season. First, the descriptive statistics presented more bursts of accelerations and decelerations in WIMU PRO than in MEDIACOACH, whereas the distances covered recorded by both systems were similar. Second, negative relationships were found (i.e., negative bias) comparing WIMU PRO to MEDIACOACH in the number of accelerations and decelerations between 0/1 m/s2 and ½ m/s2 (p < 0.05), and in the distances covered in accelerations and decelerations (p < 0.05) between 0/1 m/s2 and in accelerations and decelerations registered between 2/3 m/s2 and more than 3 m/s2. Moreover, the differences in means (i.e., standardized mean bias) across the two devices were trivial (> 0.19) and small (0.2–0.59) for most variables. The standardized typical errors in the estimate (TEE) were moderate (0.3–0.59) and small to moderate (0.1–0.29 to 0.3–0.59), respectively. Also, the Intra class Correlation Coefficients (ICCs) for agreement and consistency between systems showed good and excellent values (> 0.90). The magnitude of change in means (%) between systems, defined as the percentage change between the numbers or values, was below 14% and 7% for number and distances covered, respectively. All scores in the smallest worthwhile change were lower than 9% and in the coefficients of variation were lower than 95% and 15%, respectively. Thus, both systems demonstrated an acceptable degree of agreement and could be useful in analyzing players’ acceleration demands in professional soccer. However, caution is required when interpreting the results and a comparison with a gold standard is required in order to validate both systems.
Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
Authors: Hope Thomas M. H. , Nardo Davide , Holland Rachel , Ondobaka Sasha , Akkad Haya , Price Cathy J. , Leff Alexander P. , Crinion Jenny
Published: September 2021

Stroke is a leading cause of disability, and language impairments (aphasia) after stroke are both common and particularly feared. Most stroke survivors with aphasia exhibit anomia (difficulties with naming common objects), but while many therapeutic interventions for anomia have been proposed, treatment effects are typically much larger in some patients than others. Here, we asked whether that variation might be more systematic, and even predictable, than previously thought. 18 patients, each at least 6 months after left hemisphere stroke, engaged in a computerised treatment for their anomia over a 6-week period. Using only: (a) the patients’ initial accuracy when naming (to-be) trained items; (b) the hours of therapy that they devoted to the therapy; and (c) whole-brain lesion location data, derived from structural MRI; we developed Partial Least Squares regression models to predict the patients’ improvements on treated items, and tested them in cross-validation. Somewhat surprisingly, the best model included only lesion location data and the hours of therapy undertaken. In cross-validation, this model significantly out-performed the null model, in which the prediction for each patient was simply the mean treatment effect of the group. This model also made promisingly accurate predictions in absolute terms: the correlation between empirical and predicted treatment response was 0.62 (95% CI 0.27, 0.95). Our results indicate that individuals’ variation in response to anomia treatment are, at least somewhat, systematic and predictable, from the interaction between where and how much lesion damage they have suffered, and the time they devoted to the therapy.
DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis
Authors: Chen Hong-bin , Pineda Garcia Jorge Carlos , Arizono Shinako , Takeda Tomoki , Li Ren-shi , Hattori Yukiko , Sano Hiroe , Miyauchi Yuu , Hirota Yuko , Tanaka Yoshitaka , Ishii Yuji
Published: September 2021

Leydig cells in the testes produce testosterone in the presence of gonadotropins. Therefore, male testosterone levels must oscillate within a healthy spectrum, given that elevated testosterone levels augment the risk of cardiovascular disorders. We observed that the expression of death-associated protein-like 1 (DAPL1), which is involved in the early stages of epithelial differentiation and apoptosis, is considerably higher in the testes of sexually mature mice than in other tissues. Accordingly, Dapl1-null mice were constructed to evaluate this variation. Notably, in these mice, the testicular levels of steroidogenic acute regulatory protein (StAR) and serum testosterone levels were significantly elevated on postnatal day 49. The findings were confirmed in vitro using I-10 mouse testis-derived tumor cells. The in vivo and in vitro data revealed the DAPL1-regulated the expression of StAR involving altered transcription of critical proteins in the protein kinase A and CREB/CREM pathways in Leydig cells. The collective findings implicate DAPL1 as an important factor for steroidogenesis regulation, and DAPL1 deregulation may be related to high endogenous levels of testosterone.
Perioperative hemodynamic instability in pheochromocytoma and sympathetic paraganglioma patients
Authors: Kim Jung Hee , Lee Hyung-Chul , Kim Su-jin , Yoon Soo Bin , Kong Sung Hye , Yu Hyeong Won , Chai Young Jun , Choi June Young , Lee Kyu Eun , Lee Kwang-Woong , Min Seung-Kee , Shin Chan Soo , Park Kyu Joo
Published: September 2021

For pheochromocytoma and sympathetic paraganglioma (PPGL), surgery can be used as a curative treatment; however, the life-threatening risk of perioperative hemodynamic instability (HI) presents challenges. This study aimed to analyze the incidence and predictive factors of perioperative HI. The electronic medical records of 114 consecutive patients who underwent surgery for PPGLs at our institution were retrospectively reviewed. HI was defined as one or more episodes of systolic blood pressure > 200 mmHg or mean blood pressure < 60 mmHg during surgery. The factors predictive of perioperative HI were determined using both univariate and multivariate analyses. Intraoperative HI occurred in 79 (69.3%) patients. In multivariate analysis, α-adrenergic receptor blocker duration (days) (odds ratio, 1.015; 95% confidence interval, 1.001–1.029) was a predictor for intraoperative HI. Postoperative hypotension occurred in 36 (31.6%) patients. Higher urine epinephrine levels, and greater preoperative highest heart rate (HR) were predictive factors for postoperative hypotension in PPGL patients. Caution should be taken in perioperative management for PPGL, especially with long duration of α-adrenergic receptor blocker use, higher urine epinephrine levels, and greater preoperative highest HR.
Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target
Authors: Yamamotoya Takeshi , Nakatsu Yusuke , Kanna Machi , Hasei Shun , Ohata Yukino , Encinas Jeffrey , Ito Hisanaka , Okabe Takayoshi , Asano Tomoichiro , Sakaguchi Takemasa
Published: September 2021

Novel coronavirus disease 2019 (COVID-19) has emerged as a global pandemic with far-reaching societal impact. Here we demonstrate that Pin1 is a key cellular molecule necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagation. In this study, siRNA-mediated silencing of Pin1 expression markedly suppressed the proliferation of SARS-CoV-2 in VeroE6/TMPRSS2 cells. In addition, several recently generated Pin1 inhibitors showed strong inhibitory effects on SARS-CoV-2 proliferation, measured by both viral mRNA and protein synthesis, and alleviated the cytopathic effect (CPE) on VeroE6/TMPRSS2 cells. One compound, termed H-77, was found to block SARS-CoV-2 proliferation at an EC50 below 5 μM regardless of whether it was added to the culture medium prior to or after SARS-CoV-2 infection. The inhibition of viral N protein mRNA synthesis by H-77 implies that the molecular mechanism underlying SARS-CoV-2 inhibition is likely to be associated with viral gene transcription or earlier steps. Another Pin1 inhibitor, all-trans retinoic acid (ATRA)—a commercially available drug used to treat acute promyelocytic leukemia (APL) and which both activates the retinoic acid receptor and inhibits the activity of Pin1—similarly reduced the proliferation of SARS-CoV-2. Taken together, the results indicate that Pin1 inhibitors could serve as potential therapeutic agents for COVID-19.
Machine learning assisted design of new lattice core for sandwich structures with superior load carrying capacity
Authors: Challapalli Adithya , Li Guoqiang
Published: September 2021

Herein new lattice unit cells with buckling load 261–308% higher than the classical octet unit cell were reported. Lattice structures have been widely used in sandwich structures as lightweight core. While stretching dominated and bending dominated cells such as octahedron, tetrahedron and octet have been designed for lightweight structures, it is plausible that other cells exist which might perform better than the existing counterparts. Machine learning technique was used to discover new optimal unit cells. An 8-node cube containing a maximum of 27 elements, which extended into an eightfold unit cell, was taken as representative volume element (RVE). Numerous possible unit cells within the RVE were generated using permutations and combinations through MATLAB coding. Uniaxial compression tests using ANSYS were performed to form a dataset, which was used to train machine learning algorithms and form predictive model. The model was then used to further optimize the unit cells. A total of 20 optimal symmetric unit cells were predicted which showed 51–57% higher capacity than octet cell. Particularly, if the solid rods were replaced by porous biomimetic rods, an additional 130–160% increase in buckling resistance was achieved. Sandwich structures made of these 3D printed optimal symmetric unit cells showed 13–35% higher flexural strength than octet cell cored counterpart. This study opens up new opportunities to design high-performance sandwich structures.
Different theta connectivity patterns underlie pleasantness evoked by familiar and unfamiliar music
Authors: Ara Alberto , Marco-Pallarés Josep
Published: September 2021

Music-evoked pleasantness has been extensively reported to be modulated by familiarity. Nevertheless, while the brain temporal dynamics underlying the process of giving value to music are beginning to be understood, little is known about how familiarity might modulate the oscillatory activity associated with music-evoked pleasantness. The goal of the present experiment was to study the influence of familiarity in the relation between theta phase synchronization and music-evoked pleasantness. EEG was recorded from 22 healthy participants while they were listening to both familiar and unfamiliar music and rating the experienced degree of evoked pleasantness. By exploring interactions, we found that right fronto-temporal theta synchronization was positively associated with music-evoked pleasantness when listening to unfamiliar music. On the contrary, inter-hemispheric temporo-parietal theta synchronization was positively associated with music-evoked pleasantness when listening to familiar music. These results shed some light on the possible oscillatory mechanisms underlying fronto-temporal and temporo-parietal connectivity and their relationship with music-evoked pleasantness and familiarity.
Psychometric properties of trunk impairment scale in children with spastic diplegia
Authors: Dasoju Vedasri , Kovela Rakesh Krishna , Tedla Jaya Shanker , Sangadala Devika Rani , Reddy Ravi Shankar
Published: September 2021

The Trunk Impairment Scale (TIS) is a valid and reliable tool to assess trunk impairment in children with heterogeneous cerebral palsy. The purpose of this study was to determine the reliability and validity of the TIS in assessing children with spastic diplegic cerebral palsy. The sample was a total of 30 subjects (15 = boys, 15 = girls). All subjects underwent an assessment of the sitting component of the Gross Motor Function Measure-88 and TIS by rater 1. Rater one observed video recordings within 24 h and scored TIS for intra-rater reliability, while rater two did likewise after 48 h for inter-rater reliability. The mean and standard deviation of the TIS and sitting components of the Gross Motor Function Measure-88 were 15.66 ± 4.20 and 52.36 ± 6.26, respectively. We established intra-rater and inter-rater reliability of the TIS with Intra Class Correlation Coefficient 0.991 and 0.972, respectively. The concurrent validity of the TIS with the sitting component of the Gross Motor Function Measure-88 was good, with an r-value of 0.844 (p < 0.001). This study showed the excellent intra-rater and inter-rater reliability and high concurrent validity of the TIS in assessing children with spastic diplegic cerebral palsy.
Tender and swollen joint counts are poorly associated with disability in chikungunya arthritis compared to rheumatoid arthritis
Authors: Watson Hugh , Nogueira-Hayd Ramão Luciano , Rodrigues-Moreno Maony , Naveca Felipe , Calusi Giulia , Suchowiecki Karol , Firestein Gary S. , Simon Gary , Chang Aileen Y.
Published: September 2021

Chronic rheumatological manifestations similar to those of rheumatoid arthritis (RA) are described after chikungunya virus infection. We aimed to compare the relevance of joint counts and symptoms to clinical outcomes in RA and chronic chikungunya disease. Forty patients with chronic chikungunya arthralgia and 40 patients with RA were enrolled in a cross-sectional study. The association of tenderness and swelling, clinically assessed in 28 joints, and patient evaluations of pain and musculoskeletal stiffness with modified Health Assessment Questionnaire (HAQ) and quality of life (QoL) assessments were investigated. Tender and swollen joint counts, pain and stiffness scores were all associated with the HAQ disability index in RA (all r > 0.55, p ≤ 0.0002), but only stiffness was significantly associated with disability in chikungunya (r = 0.38, p = 0.02). Joint counts, pain and stiffness were also associated with most QoL domains in RA patients. In contrast, in chikungunya disease, tender joint counts were associated only with one QoL domain and swollen joints for none, while pain and stiffness were associated with several domains. Our results confirm the relevance of joint counts in RA, but suggest that in chronic chikungunya disease, joint counts have more limited value. Stiffness and pain score may be more important to quantify chikungunya arthritis impact.
Antimicrobial peptides: mechanism of action and lipid-mediated synergistic interactions within membranes
Authors: Juhl Dennis W. , Glattard Elise , Aisenbrey Christopher , Bechinger Burkhard
Published: September 2021

Biophysical and structural studies of peptide–lipid interactions, peptide topology and dynamics have changed our view of how antimicrobial peptides insert and interact with membranes.
Two-photon ESIPT-based fluorescent probe using 4-hydroxyisoindoline-1,3-dione for the detection of peroxynitrite
Authors: Wu Luling , Tian Xue , Lee Dong Joon , Yoon Juyoung , Lim Chang Su , Kim Hwan Myung , James Tony D.
Published: September 2021

Excited-state intramolecular proton transfer (ESIPT)-based fluorophores with two-photon excitation fluorescence (TPEF) are rare.
Enhanced 13C NMR detects extended reaction networks in living cells
Authors: Jensen Pernille Rose , Sannelli Francesca , Stauning Ludvig Tving , Meier Sebastian
Published: September 2021

Mechanistic insights into the chemistry of life can be advanced by compounding physical labelling and high-sensitivity detection.
Copper(ii)-mediated C–H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides
Authors: Kobayashi Daishiro , Kohmura Yutaka , Hayashi Junya , Denda Masaya , Tsuchiya Koichiro , Otaka Akira
Published: September 2021

Cu(ii)-mediated C–H sulphenylation or selenylation of Trp enabling the formation of a (seleno)cysteine-linkage was developed.
Probing the influence of Zn and water on solvation and dynamics in ethaline and reline deep eutectic solvents by 1H nuclear magnetic resonance
Authors: AlZahrani Yasmeen M. , Britton Melanie M.
Published: September 2021

Understanding the role of Zn and H2O in controlling speciation in reline and ethaline deep eutectic solvents by 1H NMR.
Neochlorogenic acid anchors MCU-based calcium overload for cancer therapy
Authors: Li Yonglu , Yu Xin , Deng Lingchi , Zhou Su , Wang Yaxuan , Zheng Xiaodong , Chu Qiang
Published: September 2021

NA effectively targets MCU to achieve excess calcium influx, further causing intracellular calcium overload and ROS generation, eventually leading to the apoptosis of cancerous cells.
‘Lignin and extractives first’ conversion of lignocellulosic residual streams using UV light from LEDs
Authors: Hynynen Jonna , Riddell Alexander , Achour Abdenour , Takacs Zoltan , Wallin Mats , Parkås Jim , Bernin Diana
Published: September 2021

Catalyst-free valorisation of lignin and extractives from the residual stream sawdust using energy-efficient UV-LEDs.
Investigation of the interfacial behavior of organics on sulfide semiconductor surfaces by quantum chemical calculations and molecular dynamics simulations
Authors: Zhu Haiding , Ren Xuefeng , Yan Shengxiang , Liang Xingyou , Gao Liguo , Li Yanqiang , Zhao Qidong , Ma Tingli , Liu Anmin
Published: September 2021

The presence of organic pollutants in the world is harmful to our existence and the environment.
Nanofibers of polycaprolactone containing hydroxyapatite doped with aluminum/vanadate ions for wound healing applications
Authors: Ashraf Sherif , Ahmed M. K. , Ibrahium Hala A. , Awwad Nasser S. , Abdel-Fattah E. , Ghoniem M. G.
Published: September 2021

The combined doping of aluminum and vanadate ions into the structure of hydroxyapatite encapsulated in polycaprolactone nanofibers might represent a simple approach for wound dressing design.
Photoenhanced cytosolic protein delivery based on a photocleavable group-modified dendrimer
Authors: Li Yafei , Zhou Yang , Wang Tianyi , Long Kaiqi , Zhang Yaming , Wang Weiping
Published: September 2021

An efficient photoresponsive protein delivery system was developed by exploiting the protein-binding function of a photocleavable group, DEACM.
Observation of quantum-confined exciton states in monolayer WS2 quantum dots by ultrafast spectroscopy
Authors: Zheng Shu-Wen , Wang Lei , Wang Hai-Yu , Xu Chen-Yu , Luo Yang , Sun Hong-Bo
Published: September 2021

Quantum-confined exciton states and corresponding depolarization processes in monolayer WS2 quantum dots are investigated, compared with those of WS2 nanosheets.
Cyclodextrins: promising scaffolds for MRI contrast agents
Authors: Sembo-Backonly Berthe Sandra , Estour François , Gouhier Géraldine
Published: September 2021

This review highlights that supramolecular associations using host–guest inclusion complexation and covalent linkages can improve the image contrast, the sensitivity, and the efficiency of MRI diagnosis.
Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy
Authors: Bholakant Raut , Dong Bin , Zhou Xiang , Huang Xin , Zhao Changshun , Huang Dechun , Zhong Yinan , Qian Hongliang , Chen Wei , Feijen Jan
Published: September 2021

Schematic diagram of multi-functional PMs for chemotherapy-based combined cancer therapy: combination of multiple chemotherapy drugs; combinational chemo-gene therapy; combinational chemo-phototherapy; combinational chemo-immunotherapy.
Luminescent perovskite nanocrystal composites via in situ ligand polymerization towards display applications
Authors: Zhou Jun , Fang Fan , Chen Wei , Mei Ming , Liu Peizhao , Hao Junjie , Tang Haodong , Liang Suzhe , Lei Wei , Pan Ruikun , Cheng Jiaji , Müller-Buschbaum Peter , Sun Xiao Wei , Cao Wanqiang , Zheng Keyu , Wang Kai
Published: September 2021

Herein we introduce an in situ ligand polymerization (ILP) method for the fabrication of PeNC composites with intrinsic hydrophobic surface and optimized composite morphology. The composites exhibit great potential for advanced display applications.
Assessment of the shovel-truck system operation quality at open-pit mines in Kuzbass
Authors: Voronov Anton , Khoreshok Alexey , Voronov Yuri , Voronov Artyom
Published: September 2021

Assessment of the shovel-truck system (STS) operation quality is based on the well-known method of non-expert assessment of the quality of mining machines. The methodology is based on the fundamental principles of qualimetry and allows making the assessment of functionally homogeneous machines of different sizes, types and designs based on the functional criterion of the machine, which determines its main purpose. In this work, the quality assessment is made not for a single machine, but for a set of machines, taking into account their interaction. Assessment of the STS operation quality allows us to create a basis for the selection of priority areas for its improvement. The work uses methods of mathematical modeling, data collection and processing, statistics, analysis and synthesis. A comprehensive quality assessment makes it possible to predict the level and select priority areas for improving existing STSs or STSs being projected.
Computer-aided design of multi-purpose steel headframes for mines with a new technical level
Authors: Kassikhina Elena , Rusakova Nina
Published: September 2021

The existing steel structures of the sinking headgear and permanent headframe do not meet the requirements of resource saving (metal consumption and manpower input at installation), and the present methods of the headframe designing do not fully reflect recent possibilities of applying the advanced information technologies. The technical level of the modern software makes it possible for designers to set up multiple numerical experiments to create a computer simulation that allows solving the problem without field and laboratory experiments, and therefore without special costs. In this regard, a mathematical simulation and the software based on it have been developed. The software is designed to select cross-sections of multi-purpose steel headframe elements and to calculate proper weight of its metal structures depending on the characteristics and hoisting equipment. A headframe drawing is displayed as the result of the software work including list of elements and optimal hoisting equipment obtained in accordance with the initial data. The software allows speeding up graphic work and reducing manpower input in calculations and paper work. The software allows developing a three-dimensional image of the structure and its functional blocks, based on the obtained initial parameters, as well as developing control software for units with numerical control (NC) in order to manufacture multi-purpose headframes.
Laboratory study on the propagation of edge cracks in rock-like material and its implication in coal mining
Authors: Zhang Baoliang , Zhang Shichuan , Zhao Qingshuang
Published: September 2021

Rock fracture propagation is a major hazard for mining and tunnel excavation in fractured rock masses or coal seams. A longwall mining panel with a typical dimension of 200m (width)×1000m (length)×3m (height) can be considered as an open edge crack. The fracturing processes in the vicinity of the edge crack (or the longwall panel) particularly in the roof and floor are critically important for the safety of mining operation because fracturing can lead to water inrush and dynamic loading on the working face. It’s therefore important to understand and predict the pre-existing edge crack initiation and propagation in rock masses. This paper describes a study investigating the mechanisms and pathways of rock fracture under uniaxial compression. In this study, a rock-like material which consists of model gypsum, water and diatomaceous earth at a mass ratio of 165:75:2 was used. The uniaxial compression strength of the material decreased with the increase of the length of pre-existing edge crack. During the tests, wing (tensile) cracks were first observed at the tip of the pre-existing edge crack. This was followed by secondary cracks as the loading increased. The final failure of the specimens however was dominated by tensile cracks throughout the specimens. Due to the sudden crack initiations in the specimens, the loading stress in the specimen varies stepwise, and acoustic emission (AE) energy and amplitude showed abrupt changes when crack initiated. When the crack initiation occurred, the loading stress of the specimens showed a notable retreat in the stress-strain curve, and the recorded AE energy and amplitude showed a sharp spike. These findings from this experimental study have been applied to the underground longwall mining to explain the failure mechanisms in the floor of the mining panel. The fracturing process associated with the pre-existing edge crack resembles the formation of flow channels for water inrush during longwall mining.
Mechanical characteristics of drum shearer with large mining height under oblique cutting
Authors: Ying Tian , Runxin Zhang , Qiang Zhang
Published: September 2021

In order to study the dynamic characteristics of the shearer with large mining height of 8.8 m under Oblique cutting, the spatial mechanical model of the Shearer under oblique cutting was established, the angle between the drum and the working face, the load of the drum and the dynamic characteristics of the fuselage are analyzed by discrete element method and dynamics. The results show that the maximum feed rate of the front drum is 1940mm, the maximum feed rate of the back drum is 1570mm, and the angle between the front drum and the coal wall reaches a maximum of 8° at 64s, and the cutting resistance of the front drum reaches a maximum at 80s, and finally fluctuates up and down at 3.5×105N, the cutting resistance of the back drum increases with the cutting depth, and finally fluctuates up and down at 3.0×105N. The load of the front drum is 1.2 times of that of the back drum. In the process of Oblique cutting, the support force on the lower surface of the front sliding shoe increases by 3.5×105N, the support force on the lower surface of the rear sliding shoe decreases by 2.5×105N, the support force on the upper surface of the front guiding sliding shoe increases by 1.1×105N, and the support force on the upper surface of the rear guiding sliding shoe decreases by 2.3×105N, the whole machine has the tendency of forward turning and side turning to the coal wall. The average radial force between the front rocker arm and the fuselage pin is about 1.8×106N, the average radial force between the front cylinder and the fuselage pin is about 2.2×106N, and the average radial force between the rear rocker arm and the fuselage pin is about 8.0×105N, the average radial force between the rear cylinder and the PIN shaft is about 1.3×106N, which shows that the radial force at the front of the fuselage, the rocker arm and the height of the pin shaft is obviously larger than that at the rear of the fuselage. The research results are important for the design and development of large mining height shearer.
Modern portal support for slopes
Authors: Pershin Vladimir , Budnikov Pavel , Wei-Guo Qiao
Published: September 2021

In view of the problem of the portal support of a slope, this paper summarizes four arch barrings, their main structure characteristics and disadvantages are analyzed, then a new design of in-situ reinforced concrete barring is developed for the slope mouths, the cost of barring materials and the wage of the pitmen are determined by comparing several barring structures used to support the mouths of inclined shafts.
On evaluation of complex-structured coal deposits based on their typical geometric features
Authors: Katsubin Alexander , Martyanov Victor , Grohol Milan
Published: September 2021

Information about the geological structure of Kuznetsky coal basin (Kuzbass) allows us to note that coal deposits developed by open-cast method are characterized by complicated conditions and have the following features: large length of deposits at significant depths of occurrence; coal series bedding of different thicknesses (from 1 to 40 m); different dip angles (from 3 to 90º); a significant number of dip and direction disturbances; different thickness of unconsolidated quaternary sediments (from 5 to 40 m); a wide range of strength values of rocks. In addition, there is a thickness irregularity and frequent variability of elements of occurrence of coal seams within the boundaries of a quarry field both in length and depth of mining. From the point of view of open-pit mining, such deposits are complex-structured. The factors listed above have a decisive influence on the choice of technical means, the order of development and the possibility of carrying out surface mining operations. Therefore, there is a need for a systematization of mining and geological conditions for the development of coal deposits, the purpose of which is to ensure a process of evaluation of complex-structured coal deposits for the development of coal-bearing zones by various complexes of equipment.
Progressive backfill mining technology with split and two wings
Authors: Qihua Ma , Weixiang Ma , Jianxiang Gong
Published: September 2021

:

With the large-scale development of the mining industry, soil and water loss, environmental pollution and other geological disasters ac-companied by coal mining are continually increasing. Therefore, while promoting coal mine production by relying on scientific and technological progress, measures to control and reduce the resulting disasters cannot be ignored. In this paper, taking Xiezhuang coal mine as an example, we have combined its actual production conditions to solve the environmental problems caused by the massive accumulation of surface gangue in Xiezhuang coal mine. Moreover, to improve the efficient recovery of coal resources and ensure the safety of deep resources mining, and to reduce the rock burst and the damage caused to the underground water body, a re-search on forward filling mining technology with split-wing is put forward. This paper mainly discusses the related technologies and laws of forward filling mining method with split-wing, coal mining system, technological process, and filling mining.
Rational size and stability analysis of horizontal isolated pillars in deep mining from caving to filling method
Authors: Feng Fan , Li Xibing , Chen Shaojie , Peng Dingxiao , Bian Zhuang
Published: September 2021

For mining using the caving and filling methods in metal mines, determining a suitable size for the isolated pillars—the connecting part of the extension from shallow to deep—is crucial for ensuring safety and efficiency. Considering actual cases involving deep caving and cut-and-fill mining in the Chifeng Hongling lead-zinc mine in Inner Mongolia, China, the reserved thickness range of the horizontal isolation layer is obtained via theoretical analysis. On this basis, the pre-processing software HyperMesh is used to build a high-precision hexahedral grid model of the mining area, and the three-dimensional geological model of the mining area is imported into the finite-difference software FLAC3D. The stress field, displacement field, and plastic area evolution law of pillars (horizontally isolated pillars and adjacent rib pillars) in the stope of the ninth middle section after excavation are analyzed via numerical simulation inversion of the selected scheme of horizontal isolated pillars. The numerical simulation results show that the scheme employed to retain the upper horizontal isolated pillars in the ninth middle section involves reserving thicknesses of 8 m and 32 m at average ore body thicknesses of 15 m and 35 m, respectively. These results can provide theoretical guidance and a basis for safe and efficient mining of deep metal mines.
Research on factors affecting bus fire based on numerical simulation
Authors: Xu Min , Bu Pengyi , Xin Lin , Li Chao , Han Limin , An Mingyu , Feng Mingze , Li Kaixuan
Published: September 2021

With the rapid development of economy, the number of buses and bus fire increases. This paper takes bus as the research object and uses software FDS to explore the fire smoke spread under different fire power conditions. The results show that: with the increase in fire power, the smoke in the compartment rapidly accumulates, and the heating rate is also accelerated. The visibility decreases with the diffusion of smoke in the compartment. The CO concentration increases with time. The greater the fire power, the higher the temperature which will eventually stabilize. Only the concentration of smoke near the entrance will be slightly reduced. This is also conducive to the escape of people inside the car.
Evaluation of some parameters of the interaction between detonating explosive charge and environment
Authors: Masaev Yuri , Masaev Vladislav
Published: September 2021

Both strain waves, generated by the shock wave, and expanding gaseous products of the explosion contribute to the destruction of the rocks. The role of these factors is especially obvious at explosion of soft and moderately hard rocks. The article considers some aspects of the phenomena accompanying the explosion of the detonating explosive charge on example of the unworked coal.
Study on fracture and seepage characteristics of rock mass with high water pressure caused by unloading
Authors: Zhi-Tao Ma , Yong-Qiang Cui , Ya-Chao Yang , Dai-Fu Song
Published: September 2021

Research on the damage and seepage characteristics of unloading rock with high water pressure can help to further understand the mechanism of water inrush in deep mine and to take effective measures to prevent water inrush. In this paper, the finite element software RFPA2D-Flow was used to study the failure and seepage characteristics of unloading rock coupled with high water pressure and high stress. The effects of different water pressure on the failure of unloading rock and the law of seepage were investigated. The results show that the form of unloading rock failure without water pressure is brittle; however, the failure form of unloading rock with water pressure is obviously ductile failure, and the fracture is mainly concentrated at the bottom of the rock sample with high water pressure. During unloading, the seepage coefficient of rock increased with the increase of unloading amount until sudden jump occurs, and the failure form and permeability law of the rock with different water pressure were basically the same, but the larger the water pressure difference, the smaller the effective unloading capacity is needed when the permeability coefficient suddenly jumps, this shows that the larger the water pressure difference is, the more likely the rock mass will be damaged by water inrush under unloading condition.
The determinants of strategic innovation-driven competitiveness of mining companies
Authors: Lazarenko Yuliia , Garafonova Olga , Marhasova Vyktoriia , Grigashkina Svetlana
Published: September 2021

The paper is intended to examine the main determinants of the strategic innovation-driven competitiveness of a company that operates in the mining sector. Based on the literature review and industry analysis reports, it is shown that mining companies need to develop specific capabilities in order to devise and implement appropriate innovation-driven strategies and achieve sustainable competitive advantage. As a result of the study, using a system approach a descriptive overview of the main factors affecting the strategic innovation-driven competitiveness according to the specific features of the mining industry is presented. From a practical perspective, the paper provides an analytical framework for the identification of the core organizational capabilities and managerial aspects on which attention should be especially focused in order to gain and hold a strategic competitive advantage and enhance the organizational performance of mining enterprises in the modern business environment.
Le cuivre : le nerf de la guerre
Authors: Crampon Cécile
Published: September 2021

La consommation des matières primaires et métaux a cru de manière exponentielle depuis la fin du XIXe siècle et devrait croître encore dans les décennies à venir, au regard de l’augmentation mondiale de la population, du développement des pays émergents et des nouveaux usages dans les pays développés. Le cuivre, qui est utilisé dans bon nombre de domaines, pourrait connaître un pic d’extraction à partir de 2050. Le point sur cette matière première utilisée notamment dans l’énergie et dans le cadre de la transition énergétique.
Leben mit einem Kopf-Hals-Tumor
Authors: Büntzel Jens
Published: September 2021

Jedes Jahr erkranken in Deutschland knapp 20 000 Menschen an einem Tumor der
Kopf-Hals-Region. Viele erleiden sichtbare oder hörbare Einschnitte in ihr
persönliches Leben. Für andere ist der Genuss am Essen oder die
einfache Nahrungs- und Energieaufnahme eingeschränkt. Viele von ihnen
isolieren sich selbst. Genau deshalb widmet sich dieses Heft diesen Patienten. Denn
wir Professionals sind als Haus- und Fachärzte, Pflegende und Therapeuten
auch nicht immer sicher im Umgang mit den Symptomen, Einschränkungen und
Begleiterkrankungen und verstärken oftmals so unbewusst die Einsamkeit der
Patienten und ihres persönlichen Umfelds.
Verwendung eines orientierenden Spiritual Needs Screeners bei
onkologischen Patienten
Authors: Büssing Arndt
Published: September 2021

Viele Patient*innen mit chronischen Erkrankungen haben dezidierte
existenzielle und spirituelle Bedürfnisse, die aber in der
Routineversorgung kaum berücksichtigt werden – am ehesten noch
in der palliativen Versorgung. Wenn man diese Bedürfnisse in der
Versorgung berücksichtigen möchte, da sich die
Spiritualität einer Person als wichtige Ressource im Umgang mit
schwierigen Lebenssituationen erwiesen hat, dann müssen diese auch
dokumentiert werden. Kritischer Punkt ist hierbei, dass die Frage nach den
spirituellen Bedürfnissen auch in der Anamnese-Erhebung einbezogen ist.
Dies ist in einer standardisierten und strukturierten Form mit dem
deutschsprachigen Spiritual Needs Fragebogen (SpNQ) möglich. Eine
zusätzliche, noch kürzere und damit leichter zu implementierende
Möglichkeit ist die Nutzung des SpNQ-Screeners mit 10 Items, der in
einer Gruppe von 391 Patient*innen mit Tumorerkrankungen eine gute
interne Konsistenz aufwies (Cronbachs alpha=0,86). Bei der assistierten
Beantwortung des SpNQ-Screeners können sich bereits frühzeitig
Gespräche ergeben, die im Sinne des Spiritual Care-Ansatzes zu verstehen
sind und die von den Patient*innen zumeist als hilfreich und
wertschätzend erachtet werden.
Neuerungen in der 5. Auflage der WHO
Knochentumor-Klassifikation
Authors: Jundt Gernot , Baumhoer Daniel
Published: September 2021

Mit der fünften Auflage der WHO Knochentumor-Klassifikation, die zusammen
mit der Klassifikation der Weichteiltumoren im Jahr 2020 erschienen ist, haben
sich einige Änderungen ergeben, die auch für die
tägliche Arbeit von Bedeutung sind [1].
Glaucoma following Infant Lensectomy: 2021 Update
Authors: Walton David S. , Yeung Helen H.
Published: September 2021

Purpose To review information pertaining to glaucoma following infant lensectomy surgery and to provide evidence to support the responsible mechanism of this condition.

Methods and Results Described risk factors and proposed mechanisms for infantile aphakic glaucoma were assessed. The clinical evidence observed in affected glaucoma patients was analyzed, and evidence of postoperative anterior chamber fibrosis was reviewed and interpreted.

Conclusion The review and assessment of laboratory and clinical evidence support the proposal that infantile aphakic glaucoma is caused, in part, by postoperative anterior chamber fibroization related to lens cell dispersion and active epithelial-mesenchymal transition with resultant filtration angle tissue injury and loss of function.
Can the Antivirals Remdesivir and Favipiravir Work Better Jointly? In Silico Insights
Authors: Parlak Cemal , Alver Özgür , Ouma Cecil N.M. , Rhyman Lydia , Ramasami Ponnadurai
Published: September 2021

The proverb “Old is gold” is applicable in drug discovery and the proverb “All that Glitters is not Gold” is also appropriate. In the COVID-19 era, there has been a race for drugs to be effective against SARS-CoV-2. There are reports about the uses of Remdesivir and Favipiravir as existing antivirals against virus but none have been conclusive so far. In the attempts for innovations, the combination of drugs is also under trials. Therefore, we used the density functional theory method and quantum theory of atoms in molecules to investigate drug-drug interactions involving Remdesivir and Favipiravir. The computed parameters were related to the antiviral actions of both drugs together. The results indicate enhanced antiviral activity and it will be worthy to consider additional investigations with the combination of these two drugs.
Palladium-Catalyzed Cross-Coupling of 4-(Tosyloxy)quinazolines with H-Phosphonates and Phosphine Oxides: An Efficient Access to 2-(Hetero)aryl-4-phosphorylated Quinazolines
Authors: Peng Yiyuan , Ye Xinglin , Huang Jian , Deng Zhihong
Published: September 2021

A series of 2-(hetero)aryl-4-phosphorylated quinazolines was successfully synthesized in moderate to excellent yields via a palladium-catalyzed C–O/P–H cross-coupling reaction of 4-(tosyl­oxy)quinazolines with H-phosphonates and phosphine oxides. This efficient and green methodology provides an alternative straightforward protocol for the introduction of phosphorus groups to quinazoline compounds at the C4 position via C–O activation.
The “Shirt Pocket” Technique—An Alternative for Augmentation-Mastopexy
Authors: Barbosa Marcus Vinícius Jardini , Costa de Souza Paulo Henrique , Nahas Fábio Xerfan , Ferreira Lydia Masako
Published: September 2021

Augmentation-mastopexy is a frequent procedure with high rates of early recurrence of breast ptosis, mainly after subglandular approach. The dual-plane techniques, based on the cranial dissection of the pectoralis, is the most used, but this plane does not cover the inferior pole of the breast. Then, the possibility of a downward dissection of the muscle seems to be more reasonable to retain the implant and improve postoperative results. This study aimed to review the anatomy of the pectoralis in cadavers and the use of its downward dissection to create a pocket for breast implant as a “shirt pocket.” This maneuver was associated with a superior-based dermoglandular flap to overprotect the inferior pole. No complications were related in the postoperative period. The anatomic review showed that the “shirt pocket” is a safe option if done carefully. The technique demonstrated to be feasible and seemed to be effective, being another alternative to prevent early recurrence of breast ptosis in these procedures.
Double-diffusive natural convection of non-Newtonian nanofluid considering thermal dispersion of nanoparticles in a vertical wavy enclosure
Authors: Nag Preetom , Molla Md. Mamun
Published: September 2021

The flow field, thermal field, and solutal field exposed to thermal and solutal buoyancy forces have been investigated in detail within a wavy enclosure filled with copper(Cu)–water nanofluid incorporating the non-Newtonian characteristics predicted by the power-law viscosity model. During the convection process, the random motion of ultrafine Cu-nanoparticles causing an enhanced energy exchange rate is determined using the thermal dispersion model. The governing equations in a dimensionless form are numerically solved utilizing the finite volume method incorporated with the semi-implicit method for pressure linked equations-revised algorithm. The simulations are carried out with different pertinent parameters, such as the Rayleigh number, Lewis number, power-law index, volume fraction, and buoyancy ratio. The effect of the above parameters on the local Nusselt number (Nu) and the local Sherwood number (Sh) is analyzed to understand the heat and mass transfer properties from the heated wavy surface. Results show that the heat transfer rate from the wavy surface declines, but the mass transfer rate gets stronger with growing Lewis number. Both the heat and mass transfer rates become optimum when the nanofluid behaves as a shear thinning fluid. The distribution of Nu and Sh is found to be periodically attenuated from the lower end to the upper end along the hot wavy surface. The distribution of Nu and Sh is observed to be locally maximum at the crest point of the wavy surface. New correlations to predict the average heat and mass transfer rate concerning the studied parameters are proposed with remarkable accuracy.
The effect of facility background pressure on hollow cathode operation
Authors: Hall Scott J. , Gray Timothy G. , Yim John T. , Choi Maria , Sarver-Verhey Timothy R. , Kamhawi Hani
Published: September 2021

The effect of facility background pressure on the operation of a hollow cathode in a Hall thruster-like axial magnetic field is experimentally characterized. Facility pressure was varied between 10 and 88 μTorr-Xe using a secondary flow of xenon into the test facility, and cathode operation was studied using a combination of telemetry and plasma diagnostic measurements. Increasing pressure resulted in decreased discharge voltage, cathode orifice plate temperature, and voltage and current oscillation magnitudes. The plasma diagnostics, which consisted of a radially mounted retarding potential analyzer and an ion saturation probe and emissive probe mounted to a fast reciprocating motion stage, showed that increasing pressure resulted in decreased radial high-energy ions, decreased centerline maximum plasma potential and electron temperature, and increased plasma density farther than 40 mm downstream of the cathode. The effects of background pressure on the cathode plume were largely constrained to between 50 and 100 mm downstream of the cathode, where the largest gradients of plasma potential and electron temperature occur. Experimental measurements were combined with neutral density simulations to identify that the confluence of changes in electron temperature, plasma density, and neutral density result in an increase of almost an order of magnitude in the calculated ionization rate in the same location. These results have implications for both standalone cathode tests and for improving the understanding of facility effects on cathode coupling in Hall thrusters.
Hydrodynamic effects on the energy transfer from dipoles to metal slab
Authors: Brown Daniel , Deng Hai-Yao
Published: September 2021

A systematic study of nonlocal and size effects on the energy transfer of a dipole (e.g., a molecule or a quantum dot) induced by the proximity of a metal slab is presented. Nonlocal effects are accounted for using the hydrodynamic model (HDM). We derive a general relation that connects the energy transfer rate to the linear charge density–density response function of the slab. This function is explicitly evaluated for the HDM and the local Drude model. We show that a thin metal slab can support a series of higher-frequency surface plasma wave (SPW) modes in addition to the normal SPW modes, thanks to the nonlocal effects. These modes markedly alter the response and the energy transfer process, as revealed in the structure of the energy transfer rate in the parameter space. Our findings are important for applications such as the recently developed metal-induced energy transfer imaging, which relies on accurate modeling of the energy transfer rate.