bluuebunny/crossref_metadata_2025 huggingface dataset:
Information Integration in a Smart City System—A Case Study on Air Pollution Removal by Green Infrastructure through a Vehicle Smart Routing System
Authors: Muvuna Jules , Boutaleb Tuleen , Mickovski Slobodan B. , Baker Keith , Mohammad Ghoreyshi Seyed , Cools Mario , Selmi Wissal
Published: June 2020

Over the past few years, the ‘‘smart city’’ concept has emerged as a new trend to answer challenging issues related to urban development. Transformation of a city system into a smart system is meant to improve the quality of life for its people and their way of living, its environment, economy, transport, and governance. Due to benefits associated with the concept of the smart city and associated implementation challenges, traditional city systems have been undergoing transformation into smart city systems. However, observed approaches of transformation presented disconnected and fragmented city systems that usually hamper the interaction of city subsystems with the efficient and environmentally friendly urban environment. This work emphasizes the systematic view of a city system and proposes a novel method of smart city system integration. The results of our study show that in a smart city environment, where ecosystem services are valorised, air pollution emitted by vehicles can be removed by taking into consideration information related to air pollution reduction. A case study is presented to demonstrate that, with an integrated system, information outputs on travel decisions are different and more valuable. The case study explores the operability of the system, its limitations, and potential future improvements.
Toward Cognitive Management Accounting
Authors: Pilipczuk Olga
Published: June 2020

This paper examines the impact of cognitive technologies in management accounting. The purpose of the research was to create the current management accountant skills model. The main contributions of this paper are the literature study of the future of management accounting, the study of the impact of cognitive technologies on management accounting, the labor market research, and the current management accountant skills model. The purpose of the literature study was to highlight the opportunities and challenges of the application of cognitive technologies to management accounting and the role of cognitive abilities in the management accountant profession. The labor market study was conducted in order to analyze the impact of cognitive technologies on the management accountant profession and identify the core skills required. The paper fulfills the research gap regarding the impact of cognitive information technologies on management accounting and the management accountant profession in terms of smart and sustainable organization conception. The number of job positions with cognitive analytic skills, big data skills, cognitive abilities, and additional skills and competencies was identified. Although the research reveals differences in the demand for skills and abilities among the studied countries, the common skills model for managerial accountants was successfully created.
Preparation, Characterization and CO Oxidation Performance of Ag2O/γ-Al2O3 and (Ag2O+RuO2)/γ-Al2O3 Catalysts
Authors: Ananth Antony , Jeong Rak Hyun , Boo Jin-Hyo
Published: June 2020

This research dealt with the preparation and characterization of silver oxide (SLO) nanomaterials (NMs) and their composite catalysts (i.e., silver and ruthenium oxide (SLORUO)). The prepared materials were tested for their catalytic performance in carbon monoxide (CO) oxidation. Generally, silver in its pure state is not widely used for CO oxidation due to stability and structural issues. However, the usage of subsurface oxygen and oxygen-induced reconstruction could be effective as an oxidation catalyst at a slightly high temperature. The low-temperature reaction of highly active RuO2 (RUO) is a well-known phenomenon. Thus, the possibility of using it with SLO to observe the combined catalytic behavior was investigated. The wet chemically prepared SLO and SLORUO NMs exhibited spherical and rods in spherical aggregate-type surface morphology belonging to cubic and rutile crystalline structures, respectively. The NMs and catalysts (i.e., the NMs on γ-Al2O3 catalyst support at 0.5 and 1.0 wt.% ranges) showed good thermal stability. The dry and wet CO oxidation using RUO and SLO showed concentration-dependent catalytic activity. The RUO, SLO, and SLORUO composites using 0.5 wt.% showed full CO oxidation at 200, 300, and 225 °C, respectively. The reasons for the observed activity of the catalysts are explained based on the pore characteristics, chemical composition, and dispersion using H2 temperature-programmed reduction (TPR) behaviors.
Identifying the Λb(6146)0 and Λb(6152)0 as D-Wave Bottom Baryons
Authors: Mao Qiang , Chen Hua-Xing , Yang Hui-Min
Published: June 2020

We study the Λ b ( 6146 ) 0 and Λ b ( 6152 ) 0 recently observed by LHCb using the method of Quantum Chromodynamics (QCD) sum rules within the framework of heavy quark effective theory. Our results suggest that they can be interpreted as D-wave bottom baryons of J P = 3 / 2 + and 5 / 2 + respectively, both of which contain two λ -mode excitations. We also investigate other possible assignments containing ρ -mode excitations. We extract all the parameters that are necessary to study their decay properties when using the method of light-cone sum rules. We predict masses of their strangeness partners to be m Ξ b ( 3 / 2 + ) = 6.26 − 0.14 + 0.11 GeV and m Ξ b ( 5 / 2 + ) = 6.26 − 0.14 + 0.11 GeV with the mass splitting Δ M = m Ξ b ( 5 / 2 + ) − m Ξ b ( 3 / 2 + ) = 4.5 − 1.5 + 1.9 MeV, and propose to search for them in future CMS, EIC, and LHCb experiments.
The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
Authors: Everest Holly , Hill Sarah , Daines Rebecca , Sealy Joshua , James Joe , Hansen Rowena , Iqbal Munir
Published: June 2020

Avian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry are occurring more frequently. H6Nx viruses that contain mammalian adaptation motifs pose a zoonotic threat and have caused human cases. Although currently understudied globally, H6Nx avian influenza viruses pose a substantial threat to both poultry and human health. In this review we examine the current state of knowledge of H6Nx viruses including their global distribution, tropism, transmission routes and human health risk.
Limited Cross-Protection against Infectious Bronchitis Provided by Recombinant Infectious Bronchitis Viruses Expressing Heterologous Spike Glycoproteins
Authors: Keep Sarah , Sives Samantha , Stevenson-Leggett Phoebe , Britton Paul , Vervelde Lonneke , Bickerton Erica
Published: June 2020

Gammacoronavirus infectious bronchitis virus (IBV) causes an economically important respiratory disease of poultry. Protective immunity is associated with the major structural protein, spike (S) glycoprotein, which induces neutralising antibodies and defines the serotype. Cross-protective immunity between serotypes is limited and can be difficult to predict. In this study, the ability of two recombinant IBV vaccine candidates, BeauR-M41(S) and BeauR-4/91(S), to induce cross-protection against a third serotype, QX, was assessed. Both rIBVs are genetically based on the Beaudette genome with only the S gene derived from either M41 or 4/91, two unrelated serotypes. The use of these rIBVs allowed for the assessment of the potential of M41 and 4/91 S glycoproteins to induce cross-protective immunity against a heterologous QX challenge. The impact of the order of vaccination was also assessed. Homologous primary and secondary vaccination with BeauR-M41(S) or BeauR-4/91(S) resulted in a significant reduction of infectious QX load in the trachea at four days post-challenge, whereas heterologous primary and secondary vaccination with BeauR-M41(S) and BeauR-4/91(S) reduced viral RNA load in the conjunctiva-associated lymphoid tissue (CALT). Both homologous and heterologous vaccination regimes reduced clinical signs and birds recovered more rapidly as compared with an unvaccinated/challenge control group. Despite both rIBV BeauR-M41(S) and BeauR-4/91(S) displaying limited replication in vivo, serum titres in these vaccinated groups were higher as compared with the unvaccinated/challenge control group. This suggests that vaccination with rIBV primed the birds for a boosted humoral response to heterologous QX challenge. Collectively, vaccination with the rIBV elicited limited protection against challenge, with failure to protect against tracheal ciliostasis, clinical manifestations, and viral replication. The use of a less attenuated recombinant vector that replicates throughout the respiratory tract could be required to elicit a stronger and prolonged protective immune response.
Characterization of Physicians That Might Be Reluctant to Propose HIV Cure-Related Clinical Trials with Treatment Interruption to Their Patients? The ANRS-APSEC Study
Authors: Protiere Christel , Fressard Lisa , Mora Marion , Meyer Laurence , Préau Marie , Suzan-Monti Marie , Lelièvre Jean-Daniel , Lambotte Olivier , Spire Bruno ,   the APSEC Study Group
Published: June 2020

HIV cure-related clinical trials (HCRCT) with analytical antiretroviral treatment interruptions (ATIs) have become unavoidable. However, the limited benefits for participants and the risk of HIV transmission during ATI might negatively impact physicians’ motivations to propose HCRCT to patients. Between October 2016 and March 2017, 164 French HIV physicians were asked about their level of agreement with four viewpoints regarding HCRCT. A reluctance score was derived from their answers and factors associated with reluctance identified. Results showed the highest reluctance to propose HCRCT was among physicians with a less research-orientated professional activity, those not informing themselves about cure trials through scientific literature, and those who participated in trials because their department head asked them. Physicians’ perceptions of the impact of HIV on their patients’ lives were also associated with their motivation to propose HCRCT: those who considered that living with HIV means living with a secret were more motivated, while those worrying about the negative impact on person living with HIV’s professional lives were more reluctant. Our study highlighted the need to design a HCRCT that minimizes constraints for participants and for continuous training programs to help physicians keep up-to-date with recent advances in HIV cure research.
SARS-CoV-2: An Update on Potential Antivirals in Light of SARS-CoV Antiviral Drug Discoveries
Authors: Elshabrawy Hatem A.
Published: June 2020

Coronaviruses (CoVs) are a group of RNA viruses that are associated with different diseases in animals, birds, and humans. Human CoVs (HCoVs) have long been known to be the causative agents of mild respiratory illnesses. However, two HCoVs associated with severe respiratory diseases are Severe Acute Respiratory Syndrome-CoV (SARS-CoV) and Middle East Respiratory Syndrome-CoV (MERS-CoV). Both viruses resulted in hundreds of deaths after spreading to several countries. Most recently, SARS-CoV-2 has emerged as the third HCoV causing severe respiratory distress syndrome and viral pneumonia (known as COVID-19) in patients from Wuhan, China, in December 2019. Soon after its discovery, SARS-CoV-2 spread to all countries, resulting in millions of cases and thousands of deaths. Since the emergence of SARS-CoV, many research groups have dedicated their resources to discovering effective antivirals that can treat such life-threatening infections. The rapid spread and high fatality rate of SARS-CoV-2 necessitate the quick discovery of effective antivirals to control this outbreak. Since SARS-CoV-2 shares 79% sequence identity with SARS-CoV, several anti-SARS-CoV drugs have shown promise in limiting SARS-CoV-2 replication in vitro and in vivo. In this review, we discuss antivirals described for SARS-CoV and provide an update on therapeutic strategies and antivirals against SARS-CoV-2. The control of the current outbreak will strongly depend on the discovery of effective and safe anti-SARS-CoV-2 drugs.
SOME CHALLENGES OF FORENSIC SCIENCE AND THE METHODS OF ITS FORMATION
Authors: Kohutych I.
Published: June 2020

The article analyses the problem of framing the place of forensic science in the structure of higher legal education as well as the factors that negatively affect its development, didactic and practical demand. The reasons often indifferent and, in some cases, nihilistic attitudes towards forensic science, its actual manifestations and the probability of at least some localization are given. It is particularly stated that in scientific societies, especially in the constitutional-civil direction, forensic science is perceived in an unjustifiably simplified form. It is a consequence of the dissemination of misinterpreted European approaches to determining the place of forensic science in the system of local law and education; misunderstanding of its role in legal education in general and in law enforcement in particular. It is noticed that some representatives of forensic science act not always adequate, promoting its study in the educational institutions of the system of the Ministry of education and science in a shortened variant. Accordingly, to prepare graduates “…lawyers-general practitioners majoring in “Science of Law” only. They claim that complete knowledge of forensic science is necessary for graduates of departmental higher education institutions only. Obviously, it is unacceptable since it breaks the integrity of forensic science, its traditions, self-sufficiency, and commitment in the preparation of applicants for the legal profession in all areas. Other considerations in the same context are provided and the visions of actions that could foreclose forensic science a secure and demanding future are discussed. At any rate, to make subject component of forensic science’ indifference and nihilism impossible; to prepare appropriate educational materials for teaching forensic science; the authors of research should avoid artificial innovations in their studies, which will awake years of debate and degrade the doctrine of science. Within the framework of the implementation of the dispersed approach to the unification of cognitive capabilities, and therefore to the objectively substantive interests of forensic science – methodologically adequately adjust its definition. To expand the scope of use of forensic science knowledge in a system of science or, leastways, in a system of academic discipline of forensic science – forecast and develop a separate section like “Forensic science out of criminal jurisdictions”.
ELECTRONIC SEGMENT IN THE CRIMINAL PROCEDURAL LAW OF THE REPUBLIC OF LITHUANIA
Authors: Stolitnii A.
Published: June 2020

The article deals with the study of the electronic segment of criminal process in the Republic of Lithuania. Specialized electronic tools of criminal process in the form of information systems are analyzed, including: Integrated information system of criminal process, special website; electronic monitoring device. There are also a few non-specialized electronic criminal process tools, including: audiovisual telecommunications, electronic communications, electronic and digital media. The requirements for electronic recording of individual investigative actions using photography, audio, video, filming, other means and instruments of fixation have been investigated. Requirements for electronic recording of interrogation, search, arrest, identification of a person by a photo are noted. The norms of the Criminal Procedure Law of the Republic of Lithuania governing the electronic form of a criminal case in the form of an electronic file are stored, which stores electronic procedural documents drawn up or received in the course of a pre-trial investigation signed by a secure electronic signature. The rules for electronic communication between the subjects (participants) of the pre-trial investigation are analyzed. Procedural actions in the criminal proceedings of the Republic of Lithuania, carried out by the body of pre-trial investigation, by the prosecutor or the judge may be recorded electronically. With the consent of the investigator, at the conclusion of the pre-trial investigation, a copy of the pre-trial investigation file may be transmitted electronically and a copy of the indictment by electronic means or by electronic means. It is established that the trial is accompanied by electronic recording of its progress and results, participation in the trial of criminal proceedings can be ensured by remote transmission of audio and video, and familiarization with procedural documents – on a special website and e-mail. According to the results of the study of the electronic segment, the criminal procedural law of Latvia establishes the opportunity to use such experience in the introduction of electronic technologies in domestic science and practice of criminal procedural activity, the possibility of qualitative legislative implementation of changes.
THE PROCESSES OF DIGITIZATION AND FORENSICS: A RETROSPECTIVE ANALYSIS
Authors: Dumchykov M.
Published: June 2020

The article deals with some aspects of digitalization of forensic activity, such as improving the efficiency of search and cognitive activity of an investigator using digital technologies, and effective organization of such activity. Use of computer hardware, software, various computer and digital technologies and scripting to investigate crimes. The definitions of “digital trace” and “virtual trace” demonstrate the complexity of these issues. Certain dynamic movement of criminal activity in the information environment is analyzed. Defines the concept of virtual trace as a specific trace of certain actions in the information space of computer devices and their network systems. In considering the definition of the concept of virtual trace, the views of scientists such as V.A. Meshcheriakov, V.V. Poliakov and Smushkin A.V.

The aspects of consideration of forensic digitization are identified, among which the main ones are:

– use of digital technologies to increase the effectiveness of search and cognitive activity of the investigator, effective organization of this activity at the present level, optimization of interaction of different bodies, institutions in the investigation of crimes.

– the use of information and communication technologies to investigate crimes.

– solving didactic tasks in the field of training, retraining, advanced training of investigators, criminal investigators, forensic experts, improvement of their qualification, exchange of experience.

The further question of the development of forensic science in the field of information society is investigated. It is determined in what form the information forensics will exist, namely:

A new section of classic forensics that focuses on working with digital and virtual footprints.
The new science of “digital or virtual forensics”.
3. Independent forensic science within the framework of the general theory of forensic science, which integrates the development of virtual traces, the use of new technical means of finding, fixing, research, use in proving forensically relevant information, technologies that ensure the effectiveness of the investigator.
FORENSIC EXAMINATION IN LATVIA’S CRIMINAL PROCESS
Authors: Shunevych K.
Published: June 2020

The article provides a theoretical analysis of the organization of the forensic examination in Latvia. In particular, the author investigates the organizational aspects of the forensic examination: legislative regulation of the status of the entity authorized to conduct the forensic examination; the possibility to conduct the forensic examination in criminal proceedings by private experts; peculiarities of taking up a position (obtaining a license to practice) and terminating a forensic expert etc.

It is determined that according to the legislation of Latvia the right to carry out expert activity in the Republic of Latvia belongs to both state and private experts: state experts are people who carry out their activity in the state expert institutions. Private experts are involved in carrying out expertise by concluding civil contracts as self-employed people or as the forensic experts who are members of professional non-governmental associations. There are five state expert institutions in Latvia: the State Bureau of Judicial Expertise (accredited in 2008), the Forensic Directorate of the State Police (accredited in 2006), the State Medical Examination Center (accredited in 2013), the Examination Service under the General Directorate of the State border guards and the State Riga Psychiatric and Drug Center LLC. Since 1996, the Association of Independent Experts of Latvia has been operating in Latvia, comprising private court experts.

All experts who may be involved in criminal proceedings must be certified. Certified expert information is placed in the Official Register of Forensic Experts. The Council of Forensic Experts is the compiler of the Register. The Register of Forensic Experts and any changes thereto shall be published on the website of the Judicial Administrations. In addition to the Register of Forensic Experts, there is a Register of Methods of Forensic Examination, which is also compiled by the Council of Forensic Experts.

It should be noted that in Latvia a unified standard and qualification requirements have been developed for persons wishing to carry out forensic activities, which are enshrined in the legislation of Latvia and a procedure has been developed for certification of experts, as well as certification of expert research methodologies.

At the same time, certain problems arise in practice (for example, the subjectively greater trust of the court in the expert’s conclusions provided by the state expert organization), requiring an urgent solution for the effective functioning of the system of forensic expert activity in Latvia.
Outcomes Associated with the Use of Renin-Angiotensin-Aldosterone System Blockade in Hospitalized Patients with SARS-CoV-2 Infection
Authors: Chaudhri Imran , Koraishy Farrukh M. , Bolotova Olena , Yoo Jeanwoo , Marcos Luis A. , Taub Erin , Sahib Haseena , Bloom Michelle , Ahmad Sahar , Skopicki Hal , Mallipattu Sandeep K.
Published: June 2020

Background

Data regarding the benefits or harm associated with the continuation of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), especially the effect on inflammation, in patients who are hypertensive and hospitalized with coronavirus disease 2019 (COVID-19) in the United States are unclear.

Methods

This is a single-center cohort study of patients sequentially hospitalized with COVID-19 at Stony Brook University Medical Center from March 7, 2020 to April 1, 2020, inclusive of these dates. Data collection included history of known comorbidities, medications, vital signs, and laboratory values (at admission and during the hospitalization). Outcomes include inflammatory burden (composite scores for multiple markers of inflammation), AKI, admission to the intensive care unit (ICU), need for invasive mechanical ventilation, and mortality.

Results

Of the 300 patients in the study cohort, 80 patients (27%) had history of ACEI or ARB use before admission, with 61% (49/80) of these patients continuing the medications during hospitalization. Multivariable analysis revealed that the history of ACEI or ARB use before hospitalization was not associated with worse outcomes. In addition, the continuation of these agents during hospitalization was not associated with an increase in adverse outcomes and predicted fewer ICU admissions (odds ratio, 0.25; 95% CI, 0.08 to 0.81) with a decrease in the severity of inflammatory burden (peak C-reactive protein, 6.9±3.1 mg/dl, P=0.03; peak inflammation score, 2.3±1.1 unit reduction, P=0.04).

Conclusions

Use of ACEI or ARBs before hospitalization was not associated with adverse outcomes in COVID-19, and the therapeutic benefits of continuing ACEI or ARB in patients hospitalized with COVID-19 was not offset by adverse outcomes.
Borsa İstanbul Mali Sektör Pay Senetleri Fiyatlarına Etki Eden Makroekonomik Faktörlerin Belirlenmesi
Authors: DAVER Gizay
Published: June 2020

Finansal bağlantılılık kapsamında tesis edilecek görece
proaktif risk yönetim sistemlerinin kurulmasında, kullanılması uygun olabilecek
faktörlerin tespit edilmesinin amaçlandığı  çalışmada 2011:01 – 2018:12 dönemi için TCMB
EVDS’den seçilen ayılık verilerle Borsa İstanbul mali sektör endeksi ve Borsa
İstanbul ulusal endeksi getirilerinin çoklu doğrusal regresyon modeliyle
açıklanabilirliği araştırılmıştır. Borsa
İstanbul ulusal endeksi için kurulan modelin istatistiki olarak anlamlı
olmadığı, Borsa İstanbul mali sektör endeksi için kurulan modelin ise istatistiki
olarak anlamlı olmasına rağmen modelin açıklama gücünün düşük olduğu ve M2
haricinde diğer tüm değişkenlerin istatistiki olarak anlamsız görüldüğü tespit
edilmiştir. Değişen varyans probleminin bulunma ihtimaline yönelik bulguların
tespit edilmesiyle risk gözetim mekanizması tesis edilmeye çalışırken uygun
olabilecek faktörlerin belirlenmesi için farklı modellerle çalışmanın daha
uygun olacağı sonucuna ulaşılmıştır.
Rapidly progressive fatal orbito-cerebral mucormycosis in an immunocompetent patient following entry of an insect into his eye; a case report and literature review
Authors: Mohebbi Saleh , Salem Mohammad Mahdi , Eskandarzadeh Hesam , Sanaei Ayda , Jamali Mina
Published: June 2020

Mucormycosis, an uncommon and rapidly progressive fungal infection, is mainly seen in immunocompromised patients. However, immunocompetent individuals can also be infected. Here, we present a rapidly progressive orbito-cerebral mucormycosis in an immunocompetent patient, who had a history of entry of an insect into his eye. We report an immunocompetent patient, who had a history of entry of an insect into his eye, presented with left eye panophthalmitis, cellulitis and loss of vision. He underwent orbital exenteration. Then, mucormycosis was diagnosed and amphotericin B was initiated. Left cavernous sinus and internal carotid artery involvement were found in brain magnetic resonance imaging (MRI) and cerebrovascular accident (CVA) was diagnosed. Surgical debridement of necrotic tissue was performed, and postoperatively, our patient died following CVA. Mucormycosis, as a fatal fungal infection, requires early diagnosis, appropriate early surgical and rapid antifungal management so that successful outcome can be achieved.
Acute respiratory distress syndrome in COVID-19
Authors: Dadashzadeh Nahid , Farshid Saman , Valizadeh Rohollah , Nanbakhsh Mohammad , Mohammad Rahimi Mohsen
Published: June 2020

Emerging coronavirus-related respiratory disease started from Wuhan, China in December 2019 resulted in numerous mortality following acute respiratory distress syndrome (ARDS) named COVID-19 disease. The incubation period of COVID-19 is varied from 2 days to 2 weeks; therefore oral transmission is the most hazardous issue in this incubation period. Scientists are trying to find a specific drug to treat COVID-19 disease, however there is no specific therapy yet. One of the challenging issues in the treatment process of these patients is ARDS. In the development of any type of pneumonia or ARDS, Covid-19 should be considered as an option for differential diagnosis and the first critical organ in these patients is lung. In this paper, we discussed ARDS in patients with COVID-19.
Relation between Immune cell response and stemness genes expression in breast cancer; A new approach in NANOG gene and Let7-a expression in breast cancer cell lines
Authors: Aliyari-Serej Zeynab , Ebrahimi Ayyub , Kazemi Tohid , Najafi Souzan , Roshani Elmira , Ebrahimi-Kalan Mohammad , Baradaran Behzad
Published: June 2020

Introduction: Failure and recurrence in breast cancer treatment cause a great obstacle in cancer therapy and identification of cell population named cancer stem cells (CSCs) in the tumor can be led us to define it as target in novel therapeutic strategy. Objectives: The aim of this study is the finding of correlation between stemness and metastatic characteristic, also knowing CSCs as a potential target of therapy because of its developmental behavior and similarities with normal stem cells. Materials and Methods: Here, we focus on the expression of NANOG in breast CSCs, a key molecule in the physiological process of stem cells and the Let-7a that is involved in the differentiation of the cells. Results: In this work, we found that NANOG was highly expressed in SKBR3 and down-regulation of let-7a, as a differentiation miRNA, was found in MDA-MB-468 cells. Conclusion: It will be critical for the developing of effective anti-tumor drugs, utilizing mentioned concepts. Inhibition of NANOG in combination with Let-7a up-regulation can help to decrease the stemness and increase the differentiation of CSCs. The decrease of stemness and increase of differentiation initiate the apoptotic process. So, modification in the mechanism of apoptosis beside anti-cancer drugs provide a good preclinical study goal. However, in order to these drugs become clinical, the problems of their side effects and toxicity must be solved. Differentiation of CSCs provides an optimal condition to activity of immune cells which never let them escape from immune cells by alteration of immunogenicity.
Comparing the quality of life of women suffering from breast cancer receiving palliative care and ordinary care
Authors: Khalili Seyedeh Maryam , Janati Ataei Padideh , Hazini Abdolrahim , Nasiri Malihe , Kariman Nourossadat , Ahmadi Doulabi Mahbobeh
Published: June 2020

Introduction: Breast cancer is the most prevalent cancer and leading cause of women’s mortality due to malignancy. Treatment increases the survival however it is associated with poor quality of life and bringing the patients toward palliative care. Objectives: This study was conducted to compare the quality of life in patients with breast cancer receiving palliative care and ordinary care. Patients and Methods: This descriptive-analytical study was carried out in Tehran hospitals (February to August 2017). The sample consisted of 220 breast cancer women who had completed the therapy four weeks prior to the study. The European Organization for Research and Treatment of Cancer quality of life Questionnaire (EORTC QLQ-C30), its supplementary breast cancer questionnaire (QLQ-BR23) and International Physical Activity Questionnaire (IPAQ) were applied to assess the quality of life of patients who received palliative care (n=110) and ordinary care (n=110). Descriptive and inferential statistics (t test and Mann-Whitney U test) were applied to analyze the data through SPSS 21. Results: The palliative care group demonstrated higher quality of life compared to the ordinary care group. Scores in functioning and global health were higher in the palliative care group than the ordinary care group. The palliative care group also had higher scores in sexual functioning, body image, future perspective, physical activity and lower scores in symptom scales, arm symptoms and hair loss than the ordinary care group (P<0.001). Conclusion: Palliative care provides more desired quality of life than ordinary care in breast cancer women and can be effective to improve the quality of life in these patients.
Evaluation of the relationship between CD163 positive macrophages and prognostic factors in serous ovarian tumors
Authors: Heidarpour Mitra , Hoseini-Beheshti Marjan-Sadat , Derakhshan Maryam
Published: June 2020

Introduction: Ovarian cancer is the seventh most common cancer in women and is the fifth most common cause of mortality from malignancy. Objectives: The present study was performed to evaluate the number of CD163 positive macrophages and prognostic factors in serous ovarian tumors. Materials and Methods: In the present cross-sectional study, 43 tissue samples obtained from patients with serous ovarian tumors were selected from the pathology ward of Al-Zahra hospital, Isfahan, Iran. Then, the patients’ demographic information including age, pathological results, clinical stage of the disease, degree of tissue differentiation, the number of CD163 positive macrophages, and the five-year survival rate after the surgery were recorded and evaluated. Results: Patient age, International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, lymphatic metastasis, and the five-year survival rate were positively and significantly associated with the number of CD163 positive macrophages (P <0.05). In addition, the number of CD163 positive macrophages increased the odds of the five-year survival rate in these patients by 1.490 times (P = 0.026). Conclusion: According to the results of this study, the number of CD163 positive macrophages had a significant association with the progression of ovarian cancer. Moreover, the increased number of CD163 positive macrophages increased the chance of mortality in these patients.
The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19
Authors: Zununi Vahed Sepideh , Ghiyasvand Shahram , Tolouian Ramin , Noshad Hamid , Tolouian Audrey , Mohajel Shoja Mohammadali , Ardalan Mohammadreza
Published: June 2020

Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.
Mutation in thalassemia syndrome and clinical manifestation
Authors: Tamaddoni Ahmad , Gharehdaghly Leila , Bahadoram Mohammad
Published: June 2020

Introduction: Thalassemia intermedia is a term used to define a group of patients with β thalassemia in whom the clinical severity of the disease is somewhere between the mild symptoms of the β thalassemia trait and the severe manifestations of β thalassemia major. Thalassemia intermedia shows considerable heterogeneity in phenotype and molecular basis. Objectives: The aim of this study was to identify the common mutations of beta globin gene and the relationship between genotypes and phenotypes in thalassemia intermedia patients in Mazandaran province, in the north of Iran. Patients and Methods: Fifty unrelated thalassemia intermedia patients, based on clinical and hematological characteristics including age of diagnosis, age of first blood transfusion, history of blood transfusion, mean corpuscular volume (MCV), mean cell hemoglobin (MCH), hemoglobin values, and liver and spleen status were selected. DNA of peripheral blood was extracted and common mutations in beta globin gene were analyzed by reverse dot blot (RDB) method. Results: Our study showed that 30 patients (60%) had blood transfusion. There was no obvious hepatomegaly in any of the subjects, however 40 patients (80%) showed splenomegaly among which 34 cases (68%) underwent splenectomy. Mutations analysis indicated that HBB:c.315+1G>A [IVS II-1 (G>A)] mutation was the dominant mutation and has been widely associated with the phenotypic manifestations of thalassemia intermedia patients. Conclusion: It is important to comprehend the molecular basis of thalassemia intermedia and the association between genotype and phenotype in different ethnic groups. Therefore a careful evaluation of genetic, molecular, hematological and clinical aspects is necessary to differentiate thalassemia intermedia in patients at presentation.
The association between serum vitamin D level and sperm parameters; A pilot study in a subset of Iranian infertile males
Authors: Derakhshan Maryam , Derakhshan Marzieh , Omidi Elham , Heidarpour Mitra
Published: June 2020

Introduction: Male-factor infertility affects about 7% of males in the general population. Vitamin D deficiency has been reported as an important public health issue all around the world and plays an important role in male fertility. Objectives: The aim of the present study was to investigate the association between serum levels of vitamin D and sperm parameters. Patient and Methods: We conducted this pilot cross-sectional study among infertile males who referred to Khanevadeh Specialty Hospital, Isfahan, Iran. A researcher-made checklist was used to collect data on basic characteristics of patients. Serum vitamin D level as well as sperm parameters (comprising sperm concentration, volume, vitality, total motility, progressive motility and abnormal morphology), DNA fragmentation and chromatin maturity were assessed according to standard protocols. Subjects with a serum vitamin D level of ≥30 ng/mL and 20-29 ng/mL were categorized as vitamin D sufficient and insufficient groups respectively. Results: According to our results, sperm parameters except for sperm volume were significantly different between two groups (P<0.05). There was a positive significant correlation between sperm concentration, vitality, progressive motility and total motility with serum levels of vitamin D (P<0.05). A negative significant correlation was observed between sperm abnormal morphology, DNA fragmentation and chromatin immaturity with serum levels of vitamin D (P<0.05). We did not find any significant correlation between sperm volume and serum levels of vitamin D among infertile males (P>0.05). Conclusion: The results of the current study showed that low vitamin D levels can be considered as a potential risk factor for male infertility among the Iranian population. Further large-scale studies are warranted to determine the association between male infertility with serum vitamin D level and underlying mechanisms.
STUDY OF THE POSSIBILITY OF EXTRACTION OF CHROMIUM IONS BY COMPOSITE SORBENTS
Authors: Orlova S. A. , Tuzhikov O. O. , Khokhlova T. V. , Tuzhikov O. I.
Published: June 2020

As a result of oxidative dehydropolycondensation of aniline on the surface of polymer materials, effective composite sorbents were obtained that can absorb bichromate ions from solutions. The optimal content of polyaniline was determined, which allows achieving the specific sorption capacity of composite structures of 1.49 mg-EQ/g and the degree of extraction of highly toxic chromium of 99.74 %. The developed composite sorbents have high kinetic parameters and can successfully solve the problems of treatment of waste water solutions of galvanic production.
SOME TECHNOLOGICAL FEATURES OF PRODUCING SULFUR PASTES IN A LACTAM-CONTAINING MELT
Authors: Puchkov A. F. , Spiridonova M. P. , Apevalina E. P. , Martynova E. A. , Vdovina A. O.
Published: June 2020

The article considers the technological features of obtaining sulfur pastes that have advantages over the use of conventional sulfur, which are expressed primarily in improving the physical and mechanical properties of vulcanizates based on unsaturated rubbers.
BENTONITE COMPOSITION AS A PROLONGING ANTIOXIDANT
Authors: Puchkov A. F. , Spiridonova M. P. , Rayko E. S. , Kovalev V. A. , Kutsov D. A.
Published: June 2020

Studies have shown that a bentonite composition represented by a melt of ε-caprolactam antioxidants with n-phenylenediamine derivatives accumulated in mesopores and large bentonite pores can be an effective antioxidant for rubbers.
Presentación
Authors: Lecaros Cornejo José Luis
Published: June 2020

La decisión de crear la Revista Oficial del Poder Judicial. Revista de Investigación de la Corte Suprema de Justicia de la República del Perú surge allá por el año 2007 bajo el impulso de la Presidencia de la Corte Suprema de Justicia de la República, en aquel entonces a cargo del Dr. Francisco Távara Córdova, hoy director de la revista y del Fondo Editorial de este poder del Estado.
¿Ser o no ser del Poder Judicial? Aproximación bibliográfica sobre el proceso de reforma, modernización, reestructuración y refundación de la judicatura nacional
Authors: Domínguez Haro Helder
Published: June 2020

El presente trabajo identifica, desde el ángulo bibliográfico, los diferentes aportes, propuestas, enfoques y estudios en torno a la reforma de la impartición de justicia en el Perú o llamada también modernización, reestructuración o refundación del Poder Judicial. No obstante la numerosa bibliografía sobre tan importante tema, se da cuenta de un núcleo interesante de publicaciones correspondientes al siglo XX e inicios de la presente centuria. Un primer repaso bibliográfico para promover la investigación sobre la judicatura peruana y entender su devenir histórico antecede a un oportuno análisis del autor sobre la necesidad de un cambio desde el mismo Poder Judicial, circunscrito a una teoría democrática para la gobernabilidad judicial, y que involucra la participación de los diferentes actores del sistema de justicia y de la sociedad civil, por un Poder Judicial sólido y predecible como sustento de la democracia constitucional.
La licencia y la cuota sindicales en la legislación peruana
Authors: Arévalo Vela Javier
Published: June 2020

En el presente artículo se desarrolla la regulación de la licencia y de la cuota sindicales como derechos de los dirigentes y de la organización sindical en el Texto Único Ordenado de la Ley de Relaciones Colectivas de Trabajo, aprobado por el Decreto Supremo n.o 010-2003-TR, publicado en el Diario Oficial El Peruano el 5 de octubre de 2003 (en adelante TUOLRCT) y su reglamento.
Los abogados como integrantes de una organización criminal
Authors: Delgado Castro César Antonio
Published: June 2020

La práctica habitual forense en materia penal en nuestro medio normalmente se ampara en el ejercicio abusivo del derecho a ejercer la profesión de abogado y del derecho al secreto profesional, y cuya conducta criminal violatoria de la ley penal o transgresora del Código de Ética del Abogado se justifica con el argumento manido de la conducta neutral o socialmente adecuada. Pero esta responde muchas veces a motivos de no verse eventualmente involucrados en los hechos que se investigan o de querer proteger al investigado que patrocinan —o patrocinaron—, más que a razones que de modo directo tengan que ver con el secreto profesional o con el correcto ejercicio de la profesión, por lo que nuestras autoridadesy operadores del derecho deben estar atentos para no permitir la mala utilización del ejercicio de la profesión y del derecho al secreto profesional. No existen conductas per se neutrales, pues cualquiera que genéricamente y en abstracto pueda calificarse de neutral, esto es, de penalmente irrelevante y atípica, puede adquirir sentido delictivo y ser, por tanto, penalmente relevante si se dan ciertas condiciones entre las cuales es esencial la inserción de dicha conducta en un contexto delictivo.
PRESENTACIÓN
Authors: Comité Editorial del Anuario de Arqueología
Published: June 2020

Nos es grato presentar el volumen 11 del Anuario de Arqueología (publicación del Departamento de Arqueología, Escuela de Antropología, Facultad de Humanidades y Artes, Universidad Nacional de Rosario). Este volumen reúne un conjunto de trabajos que fueran presentados como ponencias en las “V Jornadas Rosarinas de Arqueología. En el año del centenario de la reforma universitaria”, organizadas por el Departamento de Arqueología, Escuela de Antropología, Facultad de Humanidades y Artes, Universidad Nacional de Rosario y desarrolladas en la ciudad de Rosario entre los días 6 y 8 de junio de 2018. Se presentan aquí sus versiones escritas y extendidas. Los trabajos combinan distintas temáticas y casos de estudio, con un amplio repertorio espacial y temporal, reflejando la variedad de investigaciones que actualmente son desarrolladas por los miembros del Departamento de Arqueología, así como trabajos de autores externos al mismo. En suma, consideramos que este número del Anuario de Arqueología constituye, en línea con los volúmenes anteriores de la revista, una valiosa contribución a la producción y difusión de conocimiento arqueológico nacional.
ANALISIS SEMIOTIKA DALAM KESENIAN KUDA LUMPING BIMA SAKTI
Authors: Juliani Reni , Hidayati Rahma , Trisniawati Winda
Published: June 2020

This research aims to determine the meaning of Kuda Lumping Bima Sakti Art performance. The research method used is descriptive qualitative. The main research informant was Jono Suwito as an elder and handler in Kuda Lumping Bima Sakti Art. Research data was collected by conducting direct observation, interviews and documentation. The results of this research indicated that the meaning of denotation of Kuda Lumping Bima Sakti Art as a whole is a show that in every movement there is a bond of dance in culture. There are also meanings of a community life and a religious belief. The connotation meaning of Kuda Lumping Bima Sakti Art is how to respond and believe that every culture has its own beliefs and from this connotation meaning, human must believe that God and supernatural exist. And the meaning of myth of Kuda Lumping Bima Sakti Art is that in daily life humans cannot be seperated from supernatural matters. Then the key to all of Kuda Lumping Bima Sakti Art rituals is that all movements have meaning from where the dance originated. The main key is to remind humans of God or return to their origin, namely the Creator.Keywords: Semiotics, Kuda Lumping, and Bima Sakti
STRATEGI KOMUNIKASI ISLAM DALAM PEMBENTUKAN KARAKTER INSAN KAMPUS (Studi Penerapan P3AI Bagi Mahasiswa UTU)
Authors: Muzakkir Muzakkir
Published: June 2020

The practice of effective communication is to change attitudes, change thinking, and change behavior both in speech and in action. The aim of the strategy in general is to determine and communicate a picture of vision and policy. The strategy describes the direction supported by various available resources. The communication strategy undertaken is macro and the process takes place vertically pyramid. In the context of science, Islamic communication has a main reference which is a way of life for Muslims, namely the Qur'an and the Hadith of the Prophet Muhammad. These two main sources provide characteristics of Islamic communication. In addition to the Qur'an and Hadith, the books delivered by the scholars and other disciplines also contributed to the development of communication science in general and Islamic communication in particular. Islam is a guide to life, which has provided various instructions in all areas of human communication. In fostering the character of students through the Development of Islamic Education Development Program (P3AI) more concerned with the final result (pragmatic) to get directly Islamic values.Keywords: Strategic, Islam Communcation, Character Building