bluuebunny/crossref_metadata_2025 huggingface dataset:
Little Naturalists: exploring the educational potential of Museum of Veterinary Anatomy of FMVZ USP
Authors: Silva Mauricio Candido da , Leite Ana Paula Da Cruz , Oliveira Laís Allana Lima de
Published: February 2018

Levando em conta os resultados que influenciaram a estruturação do Programa Educativo do Museu de Anatomia Veterinária da FMVZ USP, o ‘Projeto Naturalistas Mirins’ objetivou o desenvolvimento de atividades educativas com professores e alunos de Ensino Fundamental I de duas escolas do município de Miracatu, Vale do Ribeira, SP. Inserido no contexto da extensão universitária, esse projeto de divulgação científica abordou temas inerentes à licenciatura em Ciências da Natureza por meio da identificação de animais, conservação ambiental, respeito e cuidado com a vida. Além desses assuntos, o projeto buscou formas de aprendizagem com esses professores e alunos em um espaço diferente da realidade de suas vidas: o cenário museal. Como principais resultados, o projeto produziu as diretrizes do Guia MAV para Professores, novas orientações temáticas relacionadas ao treinamento de professores e contribuições voltadas ao desempenho da monitoria do museu para alunos do Ensino Fundamental I. Esse projeto possibilitou também a ampliação da experiência discente de alunas da licenciatura por meio da inter-relação da prática pedagógica entre o museu universitário e a escola pública, experiência de grande valor para a discussão envolvendo a educação e universidade sob a ótica da cultura e extensão.
Using the Inquiry Cycle in a Science Club to integrate public school and university in the north coast of São Paulo state
Authors: Abel Luciano Douglas dos Santos , López María Soledad
Published: February 2018

O Centro de Biologia Marinha (CEBIMar) da USP promove algumas ações de extensão universitária, com destaque para um projeto em parceria com uma escola pública, denominado Clube de Ciências, que trabalha o processo de construção do conhecimento científico com alunos do ensino fundamental. As atividades são pautadas pelo Ensino de Ecologia no Pátio da Escola (EEPE), uma proposta didático-pedagógica que utiliza a curiosidade como base para o questionamento e investigação do ambiente. A ferramenta metodológica do EEPE é o Ciclo de Indagação, uma abordagem alternativa ao método científico convencional que presume responder uma pergunta originada da observação do ambiente por meio de uma ação que resulta numa coleta de dados, os quais levam a uma discussão e à proposição de uma nova pergunta. As atividades contaram com participação relevante dos estudantes, docentes e discentes de ambas as instituições. A forma de trabalho vem sendo avaliada e modificada desde o início do Clube, a fim de tornar a atividade cada vez mais atrativa e lúdica para os participantes. Apesar das dificuldades em manter o número de estudantes até o fim das atividades, o Clube de Ciências demonstrou ser um poderoso agente para o envolvimento da comunidade acadêmica em projetos de extensão universitária e no engajamento de alunos do ensino público com temas socioambientais.
Reply to Response: Non-Inverse J - shaped population distribution
Authors: Ankalaiah Chenchu , Mastan Thondaladinne , Reddy Mullangi Sridhar
Published: February 2018

Reply to Response: Non-Inverse J - shaped population distribution.
Black Cinematic Gesture and the Aesthetics of Contagion
Authors: Bradley Rizvana
Published: February 2018

Anna Rose Holmer’s 2015 feature film debut, The Fits, advances the stakes of black performance, particularly in relation to the critical interrogation of the loss of gesture in the history of cinema. Thinking about migration in close association with the gestural, the continued migration of gesture is endemic to black social dance forms, and this fundamentally migratory quality is central to the film’s political and aesthetic imagination.
Philosophers as Intuitive Lawyers
Authors: Arroyo Gustavo Javier
Published: February 2018

Philosophers have traditionally described themselves as “intuitive scientists”: people seeking the most justified theories about distinctive aspects of the world. Relying on insights from philosophers as Samuel Taylor Coleridge and Williams James, I argue that philosophers should be described instead as “intuitive lawyers” who defend a point of view largely by appealing to non-cognitive reasons.
Acantholimon ibrahimii (Plumbaginaceae), a new species of A. section Staticopsis from the Mediterranean part of Turkey
Authors: AKAYDIN GALIP
Published: February 2018

A new species, Acantholimon ibrahimii Akaydın, is described, illustrated and discussed in comparison with its close relative A. davisii. The new species is distinguished from the latter species mainly by the generative organs (namely the inflorescence types and petals colour), habitat type and ecological behaviour. Data are also reported on the conservation status of A. ibrahimii, which is suggested to be labelled as EN according to the IUCN categories. Furthermore, a revised key to the Turkish Acantholimon species of A. sect. Staticopsis with spike laxly distichous and scape much longer than leaves is presented.
Oricymba rhynchocephala sp. nov., a new cymbelloid diatom (Bacillariophyceae) from Xianju National Park in Zhejiang Province, China
Authors: ZHANG WEI , SHANG GUANG-XIA , KOCIOLEK J. PATRICK , WANG LI-QING , ZHANG RUI-LEI
Published: February 2018

During a survey of freshwater diatoms from Xuedong stream in the Xianju National Park, Zhejiang Province, China, a new cymbelloid species, Oricymba rhynchocephala sp. nov. has been recorded. This species is assigned to the genus Oricymba by virtue of having a ridge separating the valve face and mantle, the presence of apical pore fields, stigma with a single external opening but two internal openings, and areolae with dentate occlusions. A detailed morphological description of the new species, O. rhynchocephala, is presented, based on light and scanning electron microscopy. Oricymba rhynchocephala sp. nov. is characterized by having a linear-lanceolate outline with slightly arched valve margins towards rounded and clearly rostrate apices, as well as radiate striae. The taxon is morphologically compared with similar species of the genus Oricymba. The new species, can be easily separated from other species in Oricymba by its obvious rostrate apices. The report of this new species from Zhejiang Province adds to our understanding the morphology and distribution of the genus Oricymba in China.
Vochysia condorensis (Vochysiaceae), a new species from the Cordillera del Cóndor, Ecuador
Authors: HUAMANTUPA-CHUQUIMACO ISAU , NEILL DAVID A.
Published: February 2018

Vochysia condorensis is described and illustrated as a new species from the Cordillera del Cóndor region of southeastern Ecuador, where it occurs exclusively on plateaus of quartzitic sandstone of the Hollín Formation and adjacent slopes. The species is placed in Vochysia section Ciliantha subsection Megalanthae and is compared with its most closely related congeners within the subsection: V. duquei and V. gigantea.
Two new species of Rhodocollybia from tropical India
Authors: LATHA K. P. DEEPNA , RAJ K. N. ANIL , MANIMOHAN PATINJAREVEETTIL
Published: February 2018

Two new species of Rhodocollybia, R. ciliatomarginata and R. brevipes, are described from Kerala State, India, based on morphological and molecular data. Comprehensive descriptions, photographs, and comparisons with phenetically similar and phylogenetically related species are provided. Molecular phylogenetic analysis based on nrITS-rDNA sequences coupled with morphology confirmed both the novelty of these species and their placement in the genus Rhodocollybia. The present study forms the first documentation of the genus Rhodocollybia from south Asia.
Resolving the last combination in Tovomitidium, a synonym for Tovomita (Clusiaceae)
Authors: MARINHO LUCAS C. , FIASCHI PEDRO , AMORIM ANDRÉ M.
Published: February 2018

Tovomitidium (Clusiaceae) is a small genus from the Amazon Forest, described to accommodate T. clusiiflorum plus one segregated species from Tovomita, T. speciosum. Some authors considered Tovomitidium as synonymous with Tovomita, but online databases still point to Tovomitidium as a valid genus within the Clusiaceae. Herein, we provide comments on the two species of Tovomitidium and present arguments to reinforce our opinion they belong in Tovomita. Additionally, a new combination, synonym and lectotype are presented.
Gastrochilus dulongjiangensis (Aeridinae, Vandeae, Epidendroideae, Orchidaceae), a new species from Yunnan Province, China
Authors: LIU QIANG , GAO JIANG-YUN
Published: February 2018

Gastrochilus dulongjiangensis, a new species from Gaoligongshan National Natural Reserve, Yunnan, China, is described here. It is morphologically similar to G. pseudodistichus and G. fuscopunctatus, but can be distinguished from them by having the orbicular epichile, hypochile as wide as epichile and fusiform pollinia. A preliminary risk-of-extinction assessment shows that the new species should be regarded as Data Deficient (DD) according to the IUCN Red List Categories and Criteria.
Typifications and nomenclatural notes on Neotropical Balanophoraceae
Authors: CARDOSO LEANDRO JORGE TELLES , BRAGA JOÃO MARCELO ALVARENGA
Published: February 2018

Nomenclatural types for nine names of Neotropical Balanophoraceae are designated or clarified here. The following names are lectotypified: Helosis mexicana, Langsdorffia hypogaea, L. moritziana, Lathrophytum peckoltii, Scybalium fungiforme, and S. glaziovii. For the names Helosis brasiliensis, and Thonningia mexicana, a neotype, and a second-step lectotype are respectively designated. Furthermore, the typification of the name Langsdorffia rubiginosa is clarified here.
Khaleijomyces marinus gen. et sp. nov. (Juncigenaceae, Torpedosporales) a new lignicolous marine fungus from Saudi Arabia
Authors: ABDEL-WAHAB MOHAMED A. , EL-SAMAWATY ABD EL-RAHIM M. A. , EL GORBAN ABDALLAH M. , YASSIN MOHAMED A. , ALSAADI MARZOUQ H.
Published: February 2018

During an ongoing study of marine fungi from Saudi Arabia, an undescribed taxon was recorded on driftwood collected from intertidal zone at El Khobar sea front, Dammam city, Saudi Arabia. A new taxon, Khaleijomyces, is described in here as a new genus and a new species, K. marinus is established. Phylogenetic analyses of a combined SSU and LSU rDNA dataset position the new genus within the family Juncigenaceae, Torpedosporales. Other phylogenetic related genera are: Fulvocentrum, Juncigena and Marinokulati. The morphology of Khaleijomyces is different from the above three genera and it is characterized by apricot to reddish-brown, membranous, superficial to immersed ascomata with long, periphysate necks; faint apricot-color ascomatal venter, a common character in members of Torpedosporales; hamathecium consists of pseudoparenchymatous tissue that breaks down into catenophyses; cymbiform to fusiform, thin-walled asci, without apical apparatus; hyaline, multi-guttulate and unicellular ascospores when young becoming light-brown to brown in color and 1–4 septate in old specimens.
Immature stages of the Australian flower-loving fly Apiocera striativentris
(Diptera: Apioceridae)
Authors: FERGUSON DAVID J. , YEATES DAVID K.
Published: February 2018

The Apioceridae (Diptera) are relatively large asiloid flies with just over 140 described species worldwide. They are closely related to both Mydidae and Asilidae, and most species are found in Australia and North America, however a handful are found in both southern Africa and southern South America. The immature stages of only one species is known, the Australian beach dune inhabiting species Apiocera maritima Hardy. Like most asiloid larvae, apiocerid larvae are assumed to be predators of other soft-bodied invertebrates in the soil. Anatomically the larvae and pupae are similar to those of closely related families. The larvae are elongate, cream-coloured, subcylindrical and with a small, well-sclerotised head capsule. The pupa has a number of robust processes and spines on the head capsule and rows of distinctive bristles on the abdominal tergites. These spines and bristles are used by the pupa to drill upwards out of the soil prior to adult emergence. Here we describe the late instar larva and pupa of the Australian species A. striativentris Paramonov and compare them to the larva and pupa of the previously described species. Apiocerid larvae have distinctive, rounded abdominal segments 2-5 that may be diagnostic for the family.
Revision of Cystomastacoides van Achterberg (Hymenoptera: Braconidae)
with the description of two new species from south India
Authors: RANJITH A.P. , PRIYADHARSANAN DHARMA RAJAN , NASSER M
Published: February 2018

The rare rogadine genus Cystomastacoides van Achterberg is known from four species distributed in the Australian and Oriental regions. The genus is recorded for the first time from the Indian subcontinent with the descriptions of two new species, C. sachini Ranjith sp. nov. and C. yuvraji sp. nov. from south India. A key to the extant species is provided.
A new genus and species of felt scale (Hemiptera: Coccomorpha: Eriococcidae) from New Caledonia on an endemic species of Casuarinaceae
Authors: HODGSON CHRIS , GERMAIN JEAN-FRANÇOIS , MATILE-FERRERO DANIÈLE
Published: February 2018

A new genus of Eriococcidae, Dzumacoccus Hodgson gen. n., is erected for a new species, Dzumacoccus baylaci Hodgson, Germain & Matile-Ferrero, feeding on Gymnostoma poissonianum, a species of Casuarinaceae endemic to New Caledonia. The adult female and first-instar nymph are described and illustrated.
New species of Acanthocinini Blanchard, 1845 (Coleoptera, Cerambycidae, Lamiinae) from Ecuador and notes on Parabaryssinus lineaticollis (Gounelle, 1910)
Authors: NASCIMENTO FRANCISCO E. DE L. , MCCLARIN JIM
Published: February 2018

Three new species of Cerambycidae from Ecuador are described and illustrated: Nealcidion napoensis sp. nov, Pseudosparna triangulata sp. nov and Leptocometes longilineatus sp. nov. Notes on Parabaryssinus lineaticollis (Gounelle, 1910) and a description of the female of this species are provided.
Mesoscale Ascent in Nocturnal Low-Level Jets
Authors: Shapiro Alan , Fedorovich Evgeni , Gebauer Joshua G.
Published: February 2018

A theory for gentle but persistent mesoscale ascent in the lower troposphere is developed in which the vertical motion arises as an inertia–gravity wave response to the sudden decrease of turbulent mixing in a horizontally heterogeneous convective boundary layer (CBL). The zone of ascent is centered on the local maximum of a laterally varying buoyancy field (warm tongue in the CBL). The shutdown also triggers a Blackadar-type inertial oscillation and associated low-level jet (LLJ). These nocturnal motions are studied analytically using the linearized two-dimensional Boussinesq equations of motion, thermal energy, and mass conservation for an inviscid stably stratified fluid, with the initial state described by a zero-order jump model of a CBL. The vertical velocity revealed by the analytical solution increases with the amplitude of the buoyancy variation, CBL depth, and wavenumber of the buoyancy variation (larger vertical velocity for smaller-scale variations). Stable stratification in the free atmosphere has a lid effect, with a larger buoyancy frequency associated with a smaller vertical velocity. For the parameter values typical of the southern Great Plains warm season, the peak vertical velocity is ~3–10 cm s−1, with parcels rising ~0.3–1 km over the ~6–8-h duration of the ascent phase. Data from the 2015 Plains Elevated Convection at Night (PECAN) field project were used as a qualitative check on the hypothesis that the same mechanism that triggers nocturnal LLJs from CBLs can induce gentle but persistent ascent in the presence of a warm tongue.
The (non)use of alcohol in topless establishments: Protection for women or gender policing?
Authors: Anasti Theresa
Published: February 2018

This article considers current and proposed restrictions placed on the adult industry in Chicago in order to explore the attempts made through legislation to control legal forms of sex work, specifically exotic dancing and burlesque. I focus specifically on the recent debate within the city of Chicago as to whether or not alcohol should be allowed in places where women are topless. While exotic dance is often discussed as a type of exploitation and a cause of urban blight, burlesque is uniformly discussed as positive and empowering, which affects discussion around the introduction of alcohol into each respective club. I conclude by discussing the possibility that the differentiation between exotic dance and burlesque may be a false dichotomy, and that regulations need to be talked about in conjunction with individuals who work in these industries, instead of the assumption that politicians have the laborers’ best interests in mind.
Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing
Authors: Trivedi Nikita H , Yu Jieh-Juen , Hung Chiung-Yu , Doelger Richard P , Navara Christopher S , Armitige Lisa Y , Seshu Janakiram , Sinai Anthony P , Chambers James P , Guentzel M Neal , Arulanandam Bernard P
Published: February 2018

Macrophages are important innate immune cells that respond to microbial insults. In response to multi-bacterial infection, the macrophage activation state may change upon exposure to nascent mediators, which results in different bacterial killing mechanism(s). In this study, we utilized two respiratory bacterial pathogens, Mycobacterium bovis (Bacillus Calmette Guẻrin, BCG) and Francisella tularensis live vaccine strain (LVS) with different phagocyte evasion mechanisms, as model microbes to assess the influence of initial bacterial infection on the macrophage response to secondary infection. Non-activated (M0) macrophages or activated M2-polarized cells (J774 cells transfected with the mouse IL-4 gene) were first infected with BCG for 24–48 h, subsequently challenged with LVS, and the results of inhibition of LVS replication in the macrophages was assessed. BCG infection in M0 macrophages activated TLR2-MyD88 and Mincle-CARD9 signaling pathways, stimulating nitric oxide (NO) production and enhanced killing of LVS. BCG infection had little effect on LVS escape from phagosomes into the cytosol in M0 macrophages. In contrast, M2-polarized macrophages exhibited enhanced endosomal acidification, as well as inhibiting LVS replication. Pre-infection with BCG did not induce NO production and thus did not further reduce LVS replication. This study provides a model for studies of the complexity of macrophage activation in response to multi-bacterial infection.
Multianalytical approach for the analysis of the Codices Millenarius Maior and Millenarius Minor in Kremsmuenster Abbey, Upper Austria
Authors: Frühmann Bernadette , Cappa Federica , Vetter Wilfried , Schreiner Manfred , Father Petrus
Published: February 2018

Two precious Carolingian manuscripts kept in the library of Kremsmuenster Abbey in Upper Austria were subject of investigation. The well-known Codices Millenarius Maior (Inv. No. CC Cim 1, Fig. 1a) and Millenarius Minor (Inv. No. CC Cim 2, Fig. 1b) were studied within the framework of the Centre of Image and Material Analysis in Cultural Heritage (CIMA) in Vienna. The manuscripts are especially famous for their precious and colorful miniatures of a very early medieval period. The aim of the work was the material identification (colors and inks) used for the make-up of the two codices in order to gain a better understanding of their evolution and their provenance. The instrumentation available in the CIMA laboratories allowed performing in situ measurements using non-destructive and non-invasive analytical methods. The investigations comprised a combination of three complementary methods: X-ray fluorescence analysis (XRF), Fourier transform infrared spectrometry in the reflection mode (rFTIR) and Raman spectrometry. In addition to the identification of the pigments and inks also a detailed characterization of the parchment concerning its manufacturing process was achieved by that combination. The identification of calcium carbonates on the surface of the parchment is an indicator for the liming or whitening of the animal skin, whereas the polishing process of the parchment surface with pumice stone, left traces of silicates, detected by rFTIR. The combination of XRF and Raman spectrometry enabled the characterization of black/brown inks in the text revealing the usage of iron gall inks. For the red inks applied for text and initials vermilion and red lead were applied in both codices. Furthermore, the pigment palette used for the illumination included: lead white, orpiment/realgar, red lead, vermilion and red iron oxides as well as azurite and indigo, together with the rather rare copper chloride hydroxide. Furthermore, in both gospels the application of metal leaves as well as powders made of silver–copper and gold–copper alloys could be determined by XRF on several folios.
Clinicopathologic factors, treatment patterns, and outcomes in micropapillary urothelial carcinoma (UC).
Authors: Mendiratta Prateek , Barata Pedro C. , Koshkin Vadim S. , Belcher Allan , McKenney Jesse , Schach Kim , Isharwal Sudhir , Lee Byron , Stephenson Andrew J. , Haber Georges-Pascal , Rini Brian I. , Gilligan Timothy D. , Ornstein Moshe Chaim , Garcia Jorge A. , Grivas Petros
Published: February 2018

439

Background: Micropapillary UC remains rare yet with an aggressive phenotype. Limited data exists regarding the optimal management of this variant in the contemporary era. Methods: A retrospective analysis was performed to identity patients (pts) with micropapillary UC at the Cleveland Clinic (1997-2017). Demographic, clinico-pathological, treatment regimens, and clinical outcomes, e.g. progression-free and overall survival (PFS and OS) data were collected. Results: A total of 102 pts with median age 70.5 (46-90) at diagnosis, 84%, men, 17% never smokers were identified. Stage at diagnosis for 68 pts with available data was T1 in 29, T2 in 36, T3 in 1, T4 in 2, N+ in 5, and M+ in 4 pts, respectively. Twelve pts were initially treated with intravesical therapy for NMIBC with 58% progressing to higher stage. Overall, 81% of pts had cystectomy; of those 19% had neoadjuvant chemotherapy (NAC; 81% cisplatin-based, median 3 cycles), 21 pts received adjuvant chemotherapy and 3 pts adjuvant radiation. Of 12 pts with available data, 4 had down-staging with NAC with 1 pCR. Pathologic stage was 0is, I, II, III, IV in 4%, 10%, 9%, 9%, and 67% respectively. Overall, 61 pts had recurrent or de-novo metastatic disease (most nodal/local-regional recurrence). For patients with recurrence post-surgery (n = 31), 35% received systemic chemotherapy, 16% had salvage surgery, 10% had salvage radiation, 19% had best supportive care, and the rest were lost to follow-up or refused treatment. The most common 1st-line regimen included platinum-doublet (46%), other combinations (23%), single-agent (23%) and immune checkpoint inhibitors (8%). Overall response (CR/PR) to 1st-line treatment was 38% and median PFS was 8 months (95%CI 0-16.4). Overall, 29 pts died with recurrent/metastatic disease with a median OS (from time of diagnosis) of 39.3 months (95%CI 28.4-50.2) Median OS (from time of diagnosis) for pts treated with cystectomy was 47.1 months (95%CI 23.9-50.2). Conclusions: Micropapillary UC was associated with advanced pathologic stage at cystectomy and limited use of NAC. Responses were noted with NAC and 1st line systemic treatment. Further validation can assist in prognostication and selection/stratification in future trials.
Combination checkpoint immunotherapy and cytotoxic chemotherapy: Further results from a phase Ib/II trial of pembrolizumab and docetaxel or gemcitabine in patients with advanced or metastatic urothelial cancer.
Authors: Parikh Mamta , Pan Chong-xian , Beckett Laurel , Li Yueju , Robles Daniel , DeVisser Christina , Lara Primo
Published: February 2018

525

Background: We previously reported tolerability of pembrolizumab plus either docetaxel or gemcitabine in platinum-treated metastatic urothelial cancer patients (pts), given the hypothesis that chemotherapy might enhance tumoral neoantigen expression and modulate immunogenicity of tumor cells, potentially enhancing the response to anti-PD-1 therapy. Herein we report further results from an expansion cohort. Methods: Eligible pts had Zubrod PS 0-1, adequate end-organ function, and up to 2 prior lines of chemotherapy (at least one platinum based). Patients were treated with pembrolizumab 200 mg IV on D1 q3weeks plus either docetaxel 75 mg/m2 IV on D1 (Arm A) or gemcitabine 1000 mg/m2 IV on D1 & D8 (Arm B). Primary endpoint was safety; secondary endpoints were overall response rate (RR) and progression free-survival (PFS). Results: A total of 20 pts have enrolled, 9 in Arm A, 11 in Arm B. Mean age was 66 (range 31-84). Most common AEs ≥ Grade 3 were hyponatremia (8/20), anemia (5/20), fatigue (5/20), neutropenia (4/20), leukopenia (4/20) acute kidney injury (3/20), hypophosphatemia (3/20). There were no treatment-related deaths; 13 died from tumor progression (PD). In total, 1 pt had complete response (CR), 5 pts had partial responses (PR), 3 pts had minor responses (MR), 4 had stable disease (SD), and 7 progressed (PD); overall RR was 45% and Disease Control Rate (DCR) was 65%. Arm A had overall RR of 44%, DCR 56%. Arm B had overall RR of 45%, DCR 73%. Median PFS (overall, Arm A & Arm B) was 7, 13.3, and 5.9 months. Conclusions: The combination of pembrolizumab with either docetaxel or gemcitabine is tolerated with expected adverse effects, with evidence of efficacy. Expanded cohorts continue to enroll. Clinical trial information: NCT02437370.
Prospective randomized trial of genomic classifier impact on treatment decisions in patients at high risk of recurrence following radical prostatectomy (G-MINOR).
Authors: Morgan Todd Matthew , Miller David Christopher , Dunn Rodney , Susan Linsell , Okoth Linda , Johnson Anna , Feng Felix Y , Khurshid Ghani , Davicioni Elai , Du Plessis Marguerite , Montie James E. , Cher Michael L.
Published: February 2018

TPS154

Background: Approximately 30% of patients will have ≥pT3 disease and/or positive surgical margins at radical prostatectomy (RP), indicating a high risk of local recurrence. While current guidelines recommend consideration of adjuvant radiotherapy (aRT) in this setting, < 10% undergo aRT. The Decipher assay is a novel, tissue-based genomic classifier (GC) developed and validated in the post-RP setting as a predictor of metastasis. Current retrospective evidence suggests that patients with a high GC score may benefit from aRT, while observation may be safe for those with a lower GC score. However, there are no randomized prospective data evaluating the clinical utility of biomarkers in men with adverse features after RP. Here we see to determine the impact of GC test results on adjuvant treatment decisions for high-risk post-RP patients vs. clinical factors alone. Methods: Genomics in Michigan ImpactiNg Observation or Radiation (G-MINOR) is a 4-year (12-month enrollment, 3-year follow-up) prospective, cluster-crossover, unblinded, study of 350 subjects from twelve Urology practices in the Michigan Urological Surgery Improvement Collaborative (MUSIC). MUSIC is a physician-led quality improvement consortium nearly all academic and community urology practices within the state of Michigan. Each clinical center participating in this trial will be randomly assigned to either a Genomic Classifier (GC)-based strategy or control arm for a period of 3 months. Patients in both arms will receive a predicted risk of recurrence based on a validated clinical nomogram, the CAPRA-S score, enabling a head-to-head comparison of the Decipher assay with a freely-available validated prognostic tool. Random assignments will be generated centrally by a study statistician and provided to centers immediately before commencing enrollment in each 3-month period. Each center will have two GC and two UC enrollment periods, maintaining study-wide balance and blinding of assignments in subsequent periods. Patients will be followed for receipt of adjuvant therapy as well as oncologic (recurrence, metastasis, and death) and patient-reported quality of life. Clinical trial information: NCT02783950.
Os movimentos contestatórios no Serviço Social iberoeuropeu e da América do Norte no período de 1960 a 1980
Authors: Eiras Alexandra Aparecida Leite Toffanetto Seabra , Yazbek Maria Carmelita , Santos Cláudia Mônica dos
Published: February 2018

Resumo − Este artigo constitui-se como parte da pesquisa O Movimento de Reconceituação do Serviço Social na América Latina (Argentina, Brasil, Chile e Colômbia): determinantes históricos, interlocuções internacionais e memória. Nossa ênfase circunscreve-se a Portugal, Espanha, EUA e Canadá (1960-1980). Desse modo, pretendemos identificar as referências teórico-metodológicas do Serviço Social nesse período, em seus nexos com os “movimentos contestatórios” e com o “movimento de reconceituação latino-americano” (MRLA).  Indagamos acerca da relação entre o MRLA e o Serviço Social crítico e/ou radical, considerando suas particularidades, antecedentes, expressões e desdobramentos. Apresentamos, assim, um panorama econômico, político, social e cultural da conjuntura desses países à época. Apresentamos, ainda, os movimentos do Serviço Social crítico e/ou radical e suas referências ético-políticas e teórico-metodológicas, as quais os distinguem do Serviço Social tradicional. Por fim, indicamos, quando pertinente, as interlocuções desses movimentos/produções com o MRLA. Palavras-Chave: Serviço Social; Movimento de Reconceituação latino-americano; movimentos contestatórios na Europa ibera e na América do Norte.  Abstract − This article is part of the research “The Movement of Reconceptualization of Social Work in Latin America (Argentina, Brazil, Chile and Colombia): historical determinants, international interlocutions and memory.” Our emphasis is limited to Portugal, Spain, USA and Canada (1960-1980). In this research we intend to identify the theoretical-methodological references of social work in this period, in its links with the social contestation movements and with the Latin American reconceptualization movement (MRLA). We inquire about the relationship between the MRLA and the critical and radical social work, considering its particularities, antecedents, expressions and aftereffects. In this article, we present an economic, political, social and cultural panorama of the conjuncture of these countries at the time. We also present the movements of critical and radical social work and both their ethical-political and theoretical-methodological references, which distinguish them from traditional social work and indicate, when pertinent, the interlocutions of these movements and productions with the MRLA.Keywords: social work; Latin American reconceptualization movement; social contestation in Iberian Europe and North America.
A DIDÁTICA A SERVIÇO DA INCLUSÃO DE ESTUDANTES COM DEFICIÊNCIA NA ESCOLA COMUM
Authors: Pimentel Susana Couto
Published: February 2018

Este artigo objetiva abordar como a didática pode estar a serviço da inclusão de estudantes com deficiência inseridos na escola comum numa educação emancipadora. Esta discussão foi desenvolvida a partir de estudos realizados sobre o tema. A escola, como um espaço onde se encontram as diferenças, precisa ser um espaço de transformação social, no qual as práticas que são cotidianamente construídas podem contribuir para uma educação transformadora. Os resultados desta reflexão apontam o princípio da inclusão educacional requer compromisso com o desenvolvimento de uma didática inclusiva, que favoreça a criação de condições para que todos tenham na escola o direito de aprender e o acesso aos conhecimentos necessários para o exercício da cidadania e autonomia na sociedade.
DIMENSÕES DE ATUAÇÃO EM CONTEXTO INCLUSIVO: A AULA DE ARTE MEDIADA PELO SEGUNDO PROFESSOR
Authors: Schambeck Regina Finck , Luz Katheryne Vieira da
Published: February 2018

A presente pesquisa tem por objetivo investigar as conexões entre professoras de arte, segundo professor e a Educação Especial, de modo a compreender o ponto de vista das profissionais sobre as dificuldades e adaptações curriculares necessárias para inclusão de alunos com deficiência nas escolas regulares. As profissionais participantes desta pesquisa pertencem à rede municipal de Santo Amaro da Imperatriz do estado de Santa Catarina. A questão de pesquisa buscou identificar qual era a opinião das professoras de Arte e das professoras que atuam como segundo professor sobre a prática escolar envolvendo a Inclusão. A partir da abordagem da pesquisa qualitativa, mediante a sistematização de observações, da realização de entrevista semiestruturada e da aplicação de questionários, foi possível evidenciar as atividades desenvolvidas, as funções das segundas professoras no contexto escolar e, principalmente, ações de parceria entre as duas categorias de profissionais envolvidas no processo de inclusão de alunos com deficiência na rede municipal de ensino investigada. A análise de dados trouxe em evidência a formação inicial e/ou continuada, tangenciando aspectos que precisariam melhorar em busca de um ‘ideal’ para que a inclusão fosse efetivada no contexto analisado.
Continuous ECG monitoring in hospital: part 2, practical issues
Authors: Sampson Michael
Published: February 2018

Continuous monitoring of the electrocardiogram (ECG) is a common intervention performed by cardiac nurses. In the first article of this two-part series, we evaluated the principal indications for ECG monitoring; these are the detection of arrhythmias, monitoring for myocardial ischaemia, and measurement of the QT interval. In this second article, the practical issues surrounding ECG monitoring are evaluated. The use of 3- and 5-electrode systems is discussed, and related to ECG theory and normal coronary artery anatomy. Recommendations are made for lead selection, correct electrode placement, and the recording of 12-lead ECGs. The current article concludes with a consideration of safe practice with respect to alarm management, and considers both individual and organisational approaches to reducing inappropriate alarms.
Weather, Landscape, and Management Effects on Nitrate and Soluble Phosphorus Concentrations in Subsurface Drainage in the Western Lake Erie Basin
Authors: Pease Lindsay A. , Fausey Norman R. , Martin Jay F. , Brown Larry C.
Published: February 2018

Abstract.

Subsurface drainage, while an important and necessary agricultural production practice in the Midwest, contributes nitrate (NO3-N) and soluble phosphorus (P) to surface waters. Eutrophication (i.e., excessive enrichment of surface water by NO3-N and soluble P) supports harmful algal blooms in receiving waters. The magnitude of NO3-N and soluble P loss in subsurface drainage varies greatly by landscape, weather, and field management factors. This study evaluated both the relative and combined impacts of these factors on observed NO3-N and soluble P concentrations in subsurface drainage water in the Western Lake Erie Basin watershed. Water quality data from multiple drainage outlet sites in northwest Ohio provided evidence that the primary management factors affecting NO3-N and soluble P loss were the amount and time of fertilizer application. Results strongly support following Tri-State fertilizer recommendations and 4R nutrient stewardship principles to reduce the risk of NO3-N and soluble P loss. Results also provided evidence of NO3-N and soluble P transport to subsurface drains via different pathways. Due to differences in NO3-N and soluble P transport through the soil profile (via baseflow and preferential flow, respectively), management approaches taken to reduce one nutrient may exacerbate losses of the other. Further research is needed to address potential changes in field hydrology (and consequently the in-field transport of soluble nutrients) from different types of agricultural best management practices (BMPs) and to evaluate optimal stacking of BMPs to achieve reductions in both NO3-N and soluble P loss. Controlled drainage has a high potential for stacking with other BMPs because it is primarily a physical discharge and load reduction practice. Keywords: Agriculture, Eutrophication, Nutrient transport, Regression analysis, Water quality.
Gastric lipoma: a rare cause of haematemesis
Authors: Krishnaraj B , Dhanapal B , Shankar G , Sistla SC , Galidevara I , Suresh A
Published: February 2018

Gastric lipomas are rare benign tumours of the stomach, representing less than 3% of all benign gastric neoplasms. They are usually asymptomatic but larger lesions can present with abdominal pain, gastric outlet obstruction and haematemesis. Malignant transformation is extremely rare. Accurate preoperative diagnosis can be established with computed tomography. Being benign, extensive surgery is not necessary and simple excision of the lesion is adequate. Small asymptomatic lesions can be followed up. We present a case of 80-year-old woman with gastric submucosal lipoma who presented with haematemesis.
Giant gastrointestinal stromal tumour of the stomach: a case report with surgical treatment
Authors: Zhang Y , Wang YJ , Lu CJ , Shu GM , Bai T
Published: February 2018

We report a case of giant gastrointestinal stromal tumour of the stomach in a 71-year-old woman, with emphasis on its going through surgical resection. The physical examination and radiological findings revealed that a giant mass occupied most of the abdominal cavity. The patient underwent an en-block resection of the mass, partial resection of the distal stomach and Billroth II gastrojejunostomy. The pathological diagnosis was gastrointestinal stromal tumour. The patient had a long-term disease-free survival. We emphasise that complete surgical resection is the only effective radical treatment approach for giant gastrointestinal stroma of the stomach. In some cases, we still have the opportunity for resection of these tumours because of their expansive growth, even though the lesions are very large.
Is sarcopenia a useful predictor of outcome in patients after emergency laparotomy? A study using the NELA database
Authors: Trotter John , Johnston Judith , Ng Alvin , Gatt Marcel , MacFie John , McNaught Clare
Published: February 2018

Introduction

Studies have reported on the use of frailty as a prognostic indicator in patients undergoing elective surgery. Similar data do not exist for patients undergoing emergency surgery. The aim of this study was to evaluate the effect of preoperative sarcopenia measured by computed tomography (CT) on outcome following emergency laparotomy.

Materials and methods

Data from the National Emergency Laparotomy Audit database were retrieved for patients who had undergone an emergency laparotomy over 12 months at York NHS Foundation Trust. Sarcopenia was assessed by psoas density and area on preoperative CT. Mortality rates at 30 days and 1 year were recorded. Secondary outcomes included discharge rates to non-independent living.

Results

A total of 259 patients were included. Overall cohort 30-day and 1-year mortality was 13.9% (36/259) and 28.2% (73/259), respectively. Sarcopenia measured by psoas density was associated with increased mortality compared with patients who did not develop sarcopenia at 30 days (29.7%, 19/64, vs. 8.7%, 17/195; P < 0.001; odds ratio, OR, 4.42; 95% confidence interval, CI 2.13–9.26) and at 1 year (57.8%, 37/64, vs. 18.5%, (36/195; P < 0.001; OR 6.05; 95%CI 3.28–11.18). An increase in mortality was seen in patients with sarcopenia measured by psoas area at 30 days (21.3%, 13/61, vs. 9.1%, 17/187; OR 2.71; 95%CI 1.23–5.96, P = 0.013) and at 1 year (42.6%, 26/61, vs. 20.9%, 39/187; OR 2.82; 95% CI 1.52–5.23, P < 0.001).

Conclusions

Sarcopenia assessed by measurement of psoas density and area on CT is associated with increased mortality following emergency laparotomy. The use of sarcopenia as a predictive tool merits further attention and may be useful in patients undergoing emergency surgery.
Egy hanti nominalizátor funkciói és sajátosságai
Authors: Sipos Mária
Published: February 2018

Az alábbiakban az északi hanti ’hely’ jelentésű lexémát érintő grammatikalizációs folyamatokat mutatom be. Az ennek során létrejövő nominalizátor tipikus képviselője a nyugat-szibériai areál számos (uráli és török) nyelvére jellemző gyakorlatnak. Nominalizáló szerepe annyira kiterjedt és sokrétű, hogy feltehetőleg analógiásan olyan helyekre is behatol, ahol szintaktikalag nem lenne szükséges. Mindez a korábban rendelkezésre álló, főként folklór műfajok alapján nem volt kutatható, így ennek az elemnek a jelentőségéről az obugrisztikának korábban nem volt tudomása. A létrejött morfológiai elem vegyes tulajdonságokat mutat, sem képzőnek, sem pedig jelnek nem tekinthetjük.
A comparative study of 2d nanostructureds chiral photonic crystal connected and disconnected in terahertz (THZ) re-gime
Authors: Zinelabiddine Mezache , Benabdelaziz Fatiha , Seghaouil Samir , Chaibi Walid
Published: February 2018

The 2D nanostructureds Chiral Photonic Crystal (CPC) connected and disconnected in terahertz (THz) regime, on silicon oxide SiO2 substrates, are comparatively studied via Comsol Multiphysics 5.0. Where properties of this nanostructureds are discussed based on transmission coefficient (S21) and reflection coefficient (S11).
Mosquitoes fauna diversity, Plasmodium falciparum infection and insecticide resistance status in malaria vectors in a lagoon area in Southern Benin, West Africa
Authors: Djènontin A. , Zogo B. , Ahlonsou J. , Bouraima A. , Ibikounle M. , Courtin D. , Pennetier C.
Published: February 2018

Lagoon areas maintain ideal water conditions for mosquito breeding habitats and are thus environments with high risk
of malaria transmission. In Benin, several administrative units, among which the Sô-Ava District, are located in lagoon
areas. We conducted entomological surveys in this lagoon district from July 2014 to June 2015, in order to update
existing information on biodiversity of mosquitoes, Plasmodium falciparum infection, and insecticide resistance status in
malaria vectors. Our survey found that Culex quinquefasciatus and Mansonia africana were the most abundant species,
and that Anopheles coluzzii represented the main malaria vector in this area, followed by Anopheles melas. Only
Anopheles coluzzii was positive to Plasmudium falcimarum circum sporozoitic protein (4.2 %). An. gambiae s.l. were
susceptible to chlorpyrifos-methyl and bendiocarb but resistant to all pyrethroids tested and to pyrimiphos-methyl. The
average of kdr allelic frequency from July 2014 to June 2015 was 77.4% and that of ace1
gene was less than 1%. We
conclude that Anopheles coluzzii is the main malaria vector in the lagoon area we studied, somewhat contrary to our
expectations. However, this malaria vector was resistant to insecticides used for bed net impregnation, even if the
resistance level was lower than observed in other parts of Benin.
The comparison of femoral component rotation in the total knee arthroplasty
Authors: Chmurny M , Krivanek S , Melisik M , Rovnak M , Necas L.
Published: February 2018

Introduction Background:Optimal femoral component rotation in total knee arthroplasty (TKA) is crucial to establish a balanced knee reconstruction. Unbalanced knees can lead to instability, patellofemoral problems, persistent pain, stiffness, and generally poorer outcomes including early failure. There are several methods to achieve the femoral component rotation such as balanced gap technique, measured resection technique, and bone landmarks such as transepicondylar line (TEA) and Whiteside line. The purpose of this study was to compare the balan ced gap technique with the TEA technique.

Materials and Methods:This randomised prospective study compares the femoral component rotation obtained with the use of balanced gap technique and the TEA, as well as compares the differences due to preoperative knee desaxations. The study includes 50 knees, 19 with neutral alignment, 22 with varus, and 9 with valgus desaxation. The femoral component rotation was measured postoperatively on photodocumentation taken after determining the TEA and balanced gap technique line peroperatively. These lines were compared to the posterior femoral condyles obtaining the degree of rotation. In case of transepicondylar line it is condylar twist angle (CTA) and in case of ligament balancer rotation axis it is ligament balancer angle (LBA).

Results:The statistically significant differences in femoral component rotation using the techniques mentioned above as well as differences in individual knee desaxations were observed. The average LBA was 3.42 degrees and average CTA 3.58 in neutral knees group, but in the varus knees the average CTA value was 2.27 degrees and LBA value was 1.05 degrees. The average CTA value in patients with valgus desaxation is 4.78 degrees and LBA value is 5.22 degrees. According to Tukey Post Hoc test a statistically significant difference in LBA value is between neutral and varus knees with a significance level of p = 0.000022 and the most significant difference between varus and valgus knees with a significance level of p = 0.000011.

Conclusion:The statistically significant differences in femoral component rotation using the techniques mentioned above as well as differences in individual knee desaxations were observed.
The Notion of the Foreign in Hungarian and Bulgarian Phraseologisms
Authors: Lesnichkova Lilyana
Published: February 2018

The confrontation between the native and the foreign is a problem that focuses research efforts on a number of humanities, e.g. cultural studies, anthropology, linguistics, ethnography, etc. The following report analyses the notion of the foreign, the other, the different, reflected in the phraseological wealth of the Hungarian and Bulgarian languages. The reviewed phrasemes concentrate the shock upon collision with the different or evaluation of the experience gained in the continuous communication with the other. The foreign is usually individualized by outlining and exaggerating some of its characteristics using parallels, oppositions, and metaphors. The negative attitudes and judgments prevail over the others: the fear of the collective “I” losing its own identity creates a negative attitude towards the foreign, distorted, or wrong notion of the other and the different. Many of the idioms reflect interethnic relations from times long gone, and so they are no longer a significant part of the active vocabulary of Hungarians and Bulgarians. Their analysis, however, is of great interest as they preserve the collective memory of the Hungarian and Bulgarian cultural communities and reveal their traditional notions and knowledge.
Missing data in open-data era – a barrier to multiomics integration
Authors: Piwowar Monika , Jurkowski Wiktor
Published: February 2018

The exploration of complex interactions in biological systems is one of the main aims in nature science nowadays. Progress in this area is possible because of high-throughput omics technologies and the computational surge. The development of analytical methods “is trying to keep pace” with the development of molecular biology methods that provide increasingly large amounts of data – omics data. Specialized databases consist of ever-larger collections of experiments that are usually conducted by one next-generation sequencing technique (e.g. RNA-seq). Other databases integrate data by defining qualitative relationships between individual objects in the form of ontologies, interactions, and pathways (e.g. GO, KEGG, and String). However, there are no open-source complementary quantitative data sets for the biological processes studied, including information from many levels of the organism organization, which would allow the development of multidimensional data analysis methods (multiscale and insightful overviews of biological processes). In the paper, the lack of omics complementary quantitative data set, which would help integrate the defined qualitative biological relationships of individual biomolecules with statistical, computational methods, is discussed.