bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMANFAATAN BIODIVERSITAS BAKTERI SERASAH KOPI SEBAGAI SOLUSI PENGENDALI PENYAKIT MOLER PADA BAWANG MERAH
Authors: Dinata Gallyndra Fatkhu , Ariani Nurul , Purnomo Andik , Aini Luqman Qurata
Published: March 2021

Penyakit busuk pangkal batang/moler (Fusarium oxysporum f.sp. cepae/FOC) merupakan salah satu faktor biotik dalam produksi bawang merah yang menyebabkan kerusakan hingga 50 %. Pengendalian biologi menawarkan strategi potensial pada perlindungan tanaman yang berfokus pada peran musuh alami dalam menekan hama dan penyakit tanaman. Penelitian ini bertujuan untuk mengidentifikasi dan mengetahui jenis bakteri yang berpotensi sebagai agens hayati terhadap penyakit moler pada bawang merah. Penelitian dilaksanakan di kondisi laboratorium dan lapang menggunakan rancangan acak kelompok untuk membandingkan setiap isolat dalam mengendalikan patogen. Sebanyak 5 dari 21 isolat bakteri menunjukkan sifat antagonisme yang tinggi terhadap FOC. Kelima isolat teridentifikasi sebagai Bacillus mycoides (K1), Clostridium sp. (K2), Pseudomonas sp. (K11), Erwinia sp. (K13), dan Pseudomonas sp. (K29). Pseudomonas sp menujukkan aktivitas penghambatan jamur sebesar 61,01 % dan 73,05 % di laboratorium, sedangkan Bacillus mycoides memberikan hasil terbaik pada kondisi lapang. K2 dan K29 menunjukkan hasil terbaik dalam meningkatkan tinggi tanaman dibandingkan dengan kontrol. Sementara itu, K29 juga berpotensi meningkatkan jumlah daun dan berat basah tanaman.
Double-blind, single-center, randomized study evaluating the effectiveness of Isosorbide Mononitrate in preventing radial artery occlusion compared to placebo in patients undergoing elective percutaneous coronary procedure: study protocol
Authors: Janella Bruno Laurenti , Matsuda Camila Naomi , Pereira Rafael Daher , Magalhães Jean Michel , Silva Marcilene Aparecida da
Published: March 2021

Objectives: The primary objective of this study will be to evaluate the efficacy of subcutaneous and peri-arterial isosorbide mononitrate in preventing occlusion of the radial artery (ORA) after percutaneous coronary procedures (PCP) performed by the transradial approach (TRA). As secondary objectives, define the incidence of ORA in the institution and assess variables related to the risk of occlusion. Methods: Single-center, double-blind, randomized study, including in- and outpatients from a high complexity hospital, admitted to performing PCP, diagnostic or therapeutic, by TRA, in stable coronary conditions (elective) or acute coronary syndrome. The sample will be randomly divided into a group that will receive the medication and a control group. All participants will be submitted to palpatory assessment of radial artery patency and the Barbeau inverse test within 24 h and seven days after the procedure. This will be the first study to evaluate isosorbide mononitrate as an accessible and inexpensive pharmacological method for preventing OAR after PCP by VTR.
Strategies to implement the safe hospital-community transition and mitigate hospital readmissions
Authors: Ferreira Óscar Manuel Ramos , Baixinho Cristina Lavareda
Published: March 2021

Transition is defined as a journey made by a person between two relatively stable moments. This experience is lived over a certain period and is characterized by the appearance of changes that cause imbalances, doubts, disorganization, and interpersonal conflicts. Therefore, hospital discharge is a multiple transition (from health-illness, but also situational) from the hospital to the community, through which all individuals who have serious health problems have required hospitalization go through. If such a transition is made early and without proper planning, there is a serious risk that the discharged person will be readmitted in the short or medium-term.Recently, readmission rates have been increasing, particularly among the elderly population. This increase does not seem to be due to the severity of the diagnosis, but the comorbidities of which sick people are carriers.
Peran Sektor Pemerintah dan Swasta dalam Perkembangan Destinasi Wisata di Kabupaten Pulau Morotai
Authors: Cahyo Enggar Dwi , Nuryanti Wiendu
Published: March 2021

Morotai tourism destination is located in North Molucas Province and directly bordering with Philippines. Morotai tourism destination is one of the ten national priority tourism destination of the Republic Indonesia. Kabupaten Pulau Morotai also has one area that is used as a Special Economic Zone based on the development of tourism industry. Tourism development in this region involves many institutions, both from the government sector and from the private sector. This research was proposed to nd out about: (1) Fnding out about the role of public and private sector in the development of Morotai tourism destination, (2) Finding out the impact of all programs which run by all sector for the Morotai tourism destination area. This study uses a qualitative approach with primary data collection using data collection techniques of observation, interviews, and institutional surveys to be able to explore the phenomena that occur at the research location. Interview respondents were determined based on purposive sampling with the selection of respondents based on their respective capacities in the development of tourism destination in Kabupaten Pulau Morotai and supported by secondary data that was deemed appropriate to the research context. Data analysis techniques used descriptive analysis techniques to see sharper phenomena. This study produces the following ndings: (1) At present Central Government still dominates the course of destination development programs in Kabupaten Pulau Morotai, 2) One of the main impacts that occur is the improvement of infrastructure that supports tourism activities in Kabupaten Pulau Morotai. This condition shows that the Morotai Tourism Destinations have potential chance to become the core of tourism industry in North Moluccas Province.
Sikap Warga Desa Ekowisata Pancoh terhadap Partisipasi Perempuan Pemilik Usaha Pariwisata Berdasarkan Pengukuran Women Owned Operated Tourism Businesses (WOOTB)
Authors: Monica Anindwitya Rizqi
Published: March 2021

This research aimed to understand resident’s attitudes toward women participation in tourism businesses especially understanding potential impacts-based Women Owned and Operated Tourism Businesses (WOOTB) measurement. This research is being held in Pancoh Ecotourism Village, Turi, Sleman, Yogyakarta Special Region, Indonesia. WOOTB measurement created by Beedle (2011) through quantitative method. WOOTB is measured by six components. The components are tourism impact, tourism enhancement, economic enhancement, capacity building, community structure, and tourist contact. This measurement will seek for total score of each items from six components of WOOTB interpreted by scale that have been done by Umar (2001). By collecting the data from 100 residents from 15 – 64 years old, both who are involved and non-involved in tourism activities in Pancoh Ecotourism Village, the result shows that there are di erent attitudes from the residents. The di erence shown from the average of total score in tourism impact component, economic enhancement component, and community structure component. Other than that, there is a similarity from the component of capacity building and tourism enhancement that revealed both high average to the statement by involved and non-involved residents. Meanwhile, in the component of tourism contact about “Women owned businesses in Pancoh would result in too much contact between local women and foreign tourists” revealed a low average to the statement both from involved and non-involved residents in Pancoh Ecotourism Village.
Environmental Impacts Management of the Coachella Valley Music and Arts Festival
Authors: Larasti Anindya Kenyo
Published: March 2021

The sustainability of music festivals is an urgent issue that must be discussed. Without careful consideration of environmental impacts, the short-term economic gain becomes a long-term fiasco. Coachella, the second-largest music festival in the US and the highest-grossing festival in the world, is possible to harm the environment. It provides pressure by bringing a hundred thousands of people at the same time and place. If the festival damages the environment, it will be costly and taking a long time to preserve the ecosystem. Therefore, it is crucial to assess the management of environmental impacts to recognise how a music festival could increase its environmental sustainability. The analysis ascertained qualitatively by using an approach of energy usage, waste generated, and transport emission produced (Fredline et al., 2005).The result shows that much work has been done by Coachella organisers to reduce the environmental impact of the music festival they organised. First, the energy used in Coachella does not have too much impact on the environment because Coachella has applied sustainable energy framework. Next, in term of waste management, Coachella has been trying to minimise waste generated during the event by organising a massive waste sorting program. It can be said that the program has been quite successful at managing waste. Last, emissions produced from transport have the worst impact on the environment because it directly contributes to climate change. Furthermore, the organisers cannot control the number of vehicles used by attendees because this subject is at the preference of each attendee, and the organiser cannot fully control it.
Perspektif Konsumen terhadap Pemasaran Paket MICE pada Departemen Pemasaran Hotel Aston Madiun
Authors: Dewi Priscila Triviana
Published: March 2021

This study discusses the consumer perspective about the marketing activities of MICE packages organised by the Sales and Marketing Department at Aston Madiun Hotel and Conference Center. The component of organising marketing activities to be evaluated refers to the Marketing Mix model developed by Kotler (2014) knows as 4Ps (product, price, promotion, and place). In this study, researchers used quantitative and qualitative data. Data collection is done by distributing questionnaires to 112 respondents determined through purposive sampling, namely visitors who have purchased MICE packages at Aston Madiun Hotel and Conference Center. Data collection was also obtained from interviews with guests and the Sales and Marketing Department as organisers of hotel marketing activities, observation and literature. In order to formulate the overall evaluation steps, an analysis of the four sectors of hotel marketing activities was carried out in the form of analysis, planning, implementation, and evaluation whose results will be described descriptively. The results showed that the overall marketing mix component received a positive response from guests who had purchased the MICE package at the Aston Madiun Hotel. Two questionnaire items obtain quite low scores, namely hotel items routinely offer and update the details of MICE packages directly to companies and hotels utilising all print media for marketing MICE package activities. The data obtained from the study will be used as study material to evaluate the marketing activities of the Marketing Department in marketing an Aston Madiun Hotel service product, in the form of accuracy of analysis, product development that is in line with the main potential of the hotel, implementation of targeted market segmentation and always evaluating every marketing process that has been passed.
Elementary Teachers’ Perceptions and the Impact of a Nutrition-Integrated Pilot Curriculum
Authors: Stapp Alicia Cooper , Valliant Melinda , Knight Kathy
Published: March 2021

Studies have demonstrated the positive effects of nutrition education on elementary students’ overall well-being. However, teachers continue to report a lack of instructional time, suitable curriculum, self-efficacy, and support as barriers to integrating nutrition into the daily curriculum. To address these barriers, this study developed and implemented a 16-week standards-based nutrition-integrated curriculum entitled Fuel to Learn. Participants included fourth-grade teachers (N=9) across North Mississippi. Qualitative observational data were collected via teacher feedback after each Fuel to Learn lesson through a web-based portal. Three themes emerged from the qualitative data and were categorized as follows: (a) supporting student engagement of nutrition and academic skills with integration; (b) ease of delivery with integrated methods; and (c) meeting the demands of classroom differentiation. Quantitative data were also collected at the conclusion of the study through a curriculum evaluation survey, providing further insight into teachers’ perceptions of the curriculum. Similar to the qualitative findings, survey results suggest that teachers perceived the curriculum to be engaging, suitable, and developmentally appropriate.
How Service Learning Can Impact Medical Students’ Perceptions of Social Responsibility
Authors: McDonald Sherry A. , Cale Chris Cale , Panesar-Aguilar Sunddip , McCraney Michelle
Published: March 2021

As criticism intensifies regarding healthcare disparities, the Liaison Committee for Medical Education has added accrediting standards mandating Service Learning (SL) in their curriculum. SL is a viable educational method to enhance social responsibility and other elements of professional identity. The problem of implementing highly effective SL projects in medical education was addressed in this study. Kiely’s model of transformational SL was used in this basic qualitative study to examine 10 medical students’ experiences during an SL project. The research question for the study was focused on the students’ descriptions of their experiences to understand how they perceived changes in themselves resulting from participation in SL. Findings from the data collected with semistructured interviews indicated that medical students described SL experiences as beneficial for community integration, educating others, and gratification. They expressed disappointment that they did not know the results of their projects. They related SL experiences that were eye-opening for them and stated that SL influenced their development of compassion as well as their intent to serve their community in their future practice of medicine. The resulting research study consisted of a curriculum plan for a required, credit-bearing SL project. The research contributes to positive social change by the intentional design of a transformative SL curriculum to foster social responsibility development.
Efecto de la aplicación de estiércoles composteados en la movilidad de las fracciones químicas del Cu en un suelo contaminado con residuos mineros
Authors: Mendoza-Jiménez Mayumi Noemí , Quintero-Soriano Rosa Isela , Duarte Zaragoza Victor Manuel , Carrasco-Hernández Violeta
Published: March 2021

El intemperismo de los residuos mineros con alto contenido de sulfuros metálicos participa en la liberación y la movilidad de los metales pesados, siendouno de los principales factores de riesgo para el medioambiente y la salud pública. En este trabajo se utilizaron dos tipos de estiércol para evaluar su efecto en las fracciones químicas móviles o biodisponibles del Cu en un suelo contaminado con los residuos mineros.Se realizó un experimento usando un suelo contaminado artificialmente con 25% de residuos mineros de Zimapán, al que se agregarondosis crecientes de estiércol composteado de vaca y de cerdo (0, 3, 6, 12 y 24%). La concentración pseudo-total del Cu se determinó por espectrofotometría de absorción atómica después de una digestión ácida, mientras que las fracciones químicas del Cu se determinaron a partir de extracciones secuenciales. Los resultados obtenidos presentaron una concentración pseudo-total elevada de Cu en los residuos mineros y baja en el suelo y en ambos tipos de estiércol. En los tratamientos con mayor aplicación de estiércol de cerdo se presentó una disminución de la concentración del Cu soluble-intercambiable y un aumento de la concentración del Cu fuertemente unida a la fracción orgánica. Mientras que conel de vaca se registraron concentraciones más elevadas del Cu soluble-intercambiable y el incremento de la fracción del Cu débilmente unida a la fracción orgánica.
Una revisión sociotécnica de las redes sociales de una organización universitaria
Authors: Brandão Marco
Published: March 2021

En ese artículo se plantean los indicadores de eficiencia para las redes sociales (RS) de una organización universitaria y se proponen algunas bases teórico-prácticas para investigaciones futuras que consideren importante el creciente uso de las RS en procesos de gestión. Se trata de una revisión teórico-conceptual sobre los aspectos sociotécnicos de las RS capaces de subsidiar una metodología de evaluación. Esta investigación es de naturaleza y enfoque aplicado, con objetivos exploratorios y descriptivos, realizando un análisis sociotécnico de las RS, el estudio de los lineamientos de la organización universitaria para las RS, el análisis del flujo de la información y las proposiciones de los indicadores de eficiencia que serán mencionados. Este artículo es producto parcial del proyecto principal denominado “El flujo de información a través de las redes sociales”, que plantea como principal producto una metodología de evaluación de eficiencia de las RS de una organización universitaria.
Emerging Molecular Pathways Involved in Pathophysiology of Cardiac Remodeling
Authors: Dhiman Sunny , Palia Priyankul , Kumar Pankaj , Jamwal Shalini , Kumari Chinu
Published: March 2021

Mammalian heart is a dynamic organ that can adapt morphological changes in response to alteration in workload. Various clinical and experimental findings revealed that in response to physiological stimuli or pathological insults, the heart undergoes cardiac remodeling which can be characterized by molecular, cellular or interstitial changes and can be manifested clinically as changes in size, shape and pumping function of the heart. A Sound understanding of changes in hearts cellular and molecular components and to mediators that derive homeostatic control is necessary before a specific intervention is pursued. Summarized data of this review comprises role of various novel emerging molecular pathways involvement in the pathophysiology of cardiac remodeling.

Keywords: Cardiac remodeling, hypertrophy, protein kinase, heart failure, molecular targets, pathological insult.
Assessment of Predictors of Hyperkalemia in Cardiovascular Diseased Patients
Authors: R Manasa , Johnson Aksa , Augustine Presly Thomas , Tom Anjana
Published: March 2021

Purpose: The objective is to determine the predictors of hyperkalaemia, severity of hyperkalaemia and to access the prevalence of cardiovascular diseases

Methodology: A cross sectional observational study was conducted on the predictors of hyperkalaemia in CVD patients, in a tertiary care teaching hospital for a period of 6 months.

Results: Among 105 patients, there were 83 males and 22 females, the age group from 41-60 year shows more CVDs and 61-80 years aged patients are more prone to hyperkalaemia and shows more prevalent when compared to other age groups. The major risk factors of hyperkalaemia were Drugs (30.23%), Disease (58.13%), and Drug interactions (11.62%).Among the cardiovascular diseases, Myocardial Infarction (38%) were the most common type of CVD, while in hyperkalaemia Ischemic Heart Disease (48.83%) were more prevalent. The severity of hyperkalaemia is measured as Mild (60.46%), Moderate (37.20%), and Severe (2.32%).

Conclusion: The present study was carried out in order to assess the predictors, prevalence and severity of hyperkalaemia in cardiovascular disease patients. Our study concluded that patients with cardiovascular disease can have an increased risk of hyperkalaemia.

Keywords:  CVD, Hyperkalaemia, Cross sectional observational study, Predictors, Prevalence, Severity.
Medicinal Uses of Maslinic Acid: A Review
Authors: Choudhary Neha , Singh Narinder , Singh Ajeet Pal , Singh Amar Pal
Published: March 2021

Maslinic Acid a characteristic compound of the triterpenoid bunch got from olive which forestalls the age of favorable to fiery cytokines and oxidative pressure, found in an assortment of common sources, going from home grown cures utilized in traditional medicine to consumable vegetables and organic products present in the Mediterranean eating routine. A few investigations have demonstrated that maslinic acid a wide scope of pharmacological effects such as Antimalarial Effect, Anti-Proliferative Activity, Antitumor Activity, Antifungal Activity, Antibacterial Activity, Anti-diabetic Effect, Antioxidant effect, Anti-inflammatory Activity, Cardio protective effect, Neuroprotection effect, Antiviral Activity, Antimicrobial Activity.

Keywords:  Maslinic acid, Triterpene, edible source, Pharmacological Effects
Mesenteric lymphadenitis; a common diagnostic mimic to acute appendicitis. With radiology it is no more a diagnosis of exclusion, laparoscopy or surgery
Authors: El-Reshaid Kamel , Al-Bader Shaikha , Markova Zhaneta
Published: March 2021

Mesenteric lymphadenitis (ML) is an inflammatory response to viral infections, bacterial infections, inflammatory bowel disease, or lymphoma in the ileocecal regions.  It is a common diagnostic mimic to acute appendicitis.  It is a self-limited inflammatory process that affects mesenteric lymph nodes in the right lower quadrant (RLQ).   We present a 15 year-old-girl with low grade fever and RLQ pain.  Initial physical examination and laboratory investigations suggested acute appendicitis.  However, diagnosis of ML was established by the finding abnormal lymph nodes that are usually: (a) clusters of > 3 tender ones anterior to right psoas muscle or in the small bowel mesentery, (b) > 5 mm in diameter of short axis, and (b) rounded in shape.  In addition; the ileal or ileocecal wall is thickened (> 3 mm) over at least 5 cm of the bowel and the appendicular wall is normal and its lumen is patent.  In conclusion; this case reports indicates tha with radiology; ML can be differentiated from acute appendicitis and limits the role of invasive laparoscopy or surgery in exclusion of the latter.

Keywords: appendicitis, CT, mesenteric lymphadenitis, radiology, US.
A study on prevalence of risk factors for osteoporosis in Postmenopausal women and the importance of Osteoporosis self- assessment tool (OST) in identifying osteoporotic risk
Authors: Thomas Blessy Maria , Kuriakose Alan , Joseph Joshua John , George Nimisha , Ashok Purnima
Published: March 2021

Osteoporosis is a highly prevalent health issue among postmenopausal women, which can be prevented if identified in the early stages. The use of Osteoporosis Self - assessment Tool (OST) will help in identifying the risk of osteoporosis and hence will allow the patients to seek the best treatment if required. In this study we assessed the prevalence of risk factors for osteoporosis in 400 Postmenopausal women and have measured the osteoporotic risk using OST. The risk factors and risk scores were correlated using spearman’s rho correlation analysis. As per the postmenopausal classification, 52% of the population belonged to the late stage. Average BMI of the population was found to be 19.5 that is borderline of the normal which indicates the risk for Osteoporosis. Attaining early menopause 243(60.75%) and history of fall 223(55.75%) was the most common risk factors found in the population. Using OST, 78 patients were identified with high risk. The correlation between OST and risk factors revealed that OST is positively significant with the progression of menopausal stage. Patient education regarding the use and interpretation of OST will help to identify risk of osteoporosis; this should be implemented within the primary gynecological care units for the better outcome.

Keywords: Osteoporosis, postmenopausal women, risk factors, Osteoporosis Self - assessment Tool.
Detection of transmission change points during unlock-3 and unlock-4 measures controlling COVID-19 in India
Authors: Mandal Manisha , Mandal Shyamapada
Published: March 2021

Objective: To evaluate the efficiency of unlock-3 and unlock-4 measure related to COVID-19 transmission change points in India, for projecting the infected population, to help in prospective planning of suitable measures related to future interventions and lifting of restrictions so that the economic settings are not damaged beyond repair.
Methods: The SIR model and Bayesian approach combined with Monte Carlo Markov algorithms were applied on the Indian COVID-19 daily new infected cases from 1 August 2020 to 30 September 2020. The effectiveness of unlock-3 and unlock-4 measure were quantified as the change in both effective transmission rates and the basic reproduction number (R0).
Results: The study demonstrated that the COVID-19 epidemic declined after implementing unlock-4 measure and the identified change-points were consistent with the timelines of announced unlock-3 and unlock-4 measure, on 1 August 2020 and 1 September 2020, respectively.
Conclusions: Changes in the transmission rates with 100% reduction as well as the R0 attaining 1 during unlock-3 and unlock-4 indicated that the measures adopted to control and mitigate the COVID-19 epidemic in India were effective in flattening and receding the epidemic curve.
Keywords: COVID-19 in India, epidemiological parameters, unlock-3 and unlock-4, SIR model, Bayesian inference, Monte Carlo Markov sampling
Assessment of Good Pharmacy Practice among Community Pharmacist and their Perceptions on Ethical Dilemmas
Authors: Anwar T.T. Muhammed , Rajalakshmi G.R.
Published: March 2021

Drugs are the prime member of any disease prevention plans and ailment treatment programmes. Pharmacists are the health professionals appointed by relevant authorities for safe and efficacious use of drugs, since they are the specially upskilled and trained personnel for controlling, organizing and distribution of medicines. Medicine alone does not provide desired treatment output. In order to achieve the optimal treatment goals pharmacist must provide enhanced drug related needs and ensure the services are of proper quality. This study aims to assess the Good Pharmacy Practice among community pharmacist, determine the frequency of ethical dilemma at community pharmacy settings and to assess the reasons why community pharmacists may compromise ethical values.It was a descriptive cross - sectional study carried out in different community pharmacies in Kozhikode district of Kerala. The study was executed in 6 months time period. The sample size was 115 community pharmacists working in Kozhikode district. Total of 120 subjects were enrolled and data were collected using a validated self-administered questionnaire. The result shows that most of the pharmacists were providing quality services to the patients and they are facing various ethical dilemma situations in their day today life. They were facing ethical dilemma situation at least once in three months. Community pharmacists compromise on ethical values and ethical issues mainly for protecting their job. The physicians request and employer’s invasion into their activities has a great role in ethical dilemma situations and thus violating the rules. Keywords: GPP, community pharmacy, ethical dilemma, pharmacy services.
In Silico Identification of Flavonoids from Corriandrum sativum Seeds against Coronavirus Covid-19 Main Protease
Authors: Suresh Kumar G , Manivannan R. , Nivetha B.
Published: March 2021

Molecular docking analysis is routinely used in modern drug research to understand and predict the relationship between a drug molecule and a target protein from a microbe. The entry and replication of pathogens in host cells can be prevented by drugs identified in this way. The coronavirus disease associated with SARS-CoV-2, COVID-19, has become today's most infectious and lethal pandemic disease in the world. Burgeoning in the absence of any particular vaccine or therapeutic agent against SARS-CoV-2.The situation urges the need for appropriate medications to treat patients infected with the virus. Consequently, the study focus on evaluate the therapeutic potential of flavonoids present in Corriandrum sativum seeds that could serve as suitable remedies for COVID19.We analyzed the binding affinity of four flavonoids were screened against Mpro protein of SARS-CoV-2 by PyRx Virtual Screening tool and also results are validated with Lig-Plot Plus. Lopinavir shows binding affinity of -8.3 Kcal/mol and exhibit stable, strong interaction with active site of COVID19 main protease. Besides flavonoids, Rutin found to have the highest binding affinity compared to Lopinavir with the Mpro protease, followed by Chlorogenic acid, Quercetin and Caffeic acid. The present study concludes that Rutin present in the integrant of seeds shows the highest potentiality for acting as in inhibitor of main protease enzyme. Further, characterization of the amino acid residues comprising the viral binding site and the nature of the hydrogen bonding involved in the ligand receptor interaction shows significant findings with Rutin binding to the MPro protein at  amino acid. The amino acid acid present in active sites of Mpro protease responsible for virus pathogenicity. The findings of the present study need in vivo experiments to prove the utility of Rutin compounds and further use in making Corriandrum sativum seeds as anti-SARS-CoV-2 product in near future.

Keywords: Corriandrum sativum seeds,Novel Coronavirus, SARS-CoV2, COVID-19, Protease, Molecular Docking.
Nano Sponges: A Novel Approach for Targeted Drug Delivery Systems
Authors: Muni Raja Lakshmi K. , Suma Shree CH. , Lakshmi Priya N.
Published: March 2021

Targeted drug delivery system is a unique type of medication conveyance framework where the pharmacologically dynamic specialists mainly focused on its site activity and not to the non-focused on organs, tissues or cells. Nano sponges are such sort of compelling pharmaceutical transporters, which take care of issues like harmfulness and helpless bioavailability such as they can stack both hydrophilic and hydrophobic medicines. Various classifications of medications can stack into Nano sponge for focused medication conveyance. This targeted drug delivery system is one of the most encouraging methodologies in the existence of science. Nano sponges are little in size with a three-dimensional organization and nanometric depression. Nano sponges are exceptionally permeable and have the extraordinary capacity to ensure dynamic particles and offer programmable delivery. This Review article explains the overall presentation of nano sponges a grouping of nano sponge trademark highlights of nano sponges their points of interest inconveniences, and synthetic compounds utilized in their planning, arrangement of technical factors influencing on the preparation component activities and assessment boundaries with some particular applications. 

Keywords: Nano sponges; Targeted drug delivery; Solubility Enhancement; controlled drug delivery.
Physicochemical and Phytochemical Studies on Sphaeranthus indicus Linn. with HPTLC Fingerprinting
Authors: Garg Mohit , Dwivedi Neelesh
Published: March 2021

Ayurveda, the oldest paradigm of health and healing known to the world, grew out of the Rishi tradition. The medical and research community is constantly seeking for new natural agents. Sphaeranthus indicus Linn. (Gorakhmundi, Family: Asteraceae), is widely used in Ayurvedic system of medicine to treat various diseases. The present investigation was designed to perform physicochemical and phytochemical analysis with HPTLC fingerprints of Sphaeranthus indicus (leave, flower, and stem) to establish the standard parameters of this herb. Different analytical parameters like extractive values, total ash, acid insoluble ash and water-soluble ash, moisture content, pH values of different parts of the drug were performed. Preliminary phytochemical screening was done to detect and quantify different active constituents such as alkaloids, flavanoids, proteins and total poly phenol using various analytical methods. Our preliminary data of phytochemical screening of the extracts revealed the presence of steroids, carbohydrates, proteins, terpenoid, flavonoid, tannins, alkaloids, resin and saponin. In the current study we established the HPTLC fingerprint of the extract using phytochemical standards. We believe that our study provides a substantial data for identification, purification, standardization, and phytochemical characterization of novel therapeutic compounds that can be used potential drug to combat various diseases for betterment of mankind.

Keywords: Sphaeranthus indicus, Ayurveda, physicochemical, UV- Spectrophotometer, HPTLC
A Review on Bio-Polymers Derived from Animal Sources with Special Reference to their Potential Applications
Authors: Paul Sujata , Das Biplajit , Sharma Hemanta Kumar
Published: March 2021

Biopolymers are naturally found material and most of the materials are made in nature during the life cycles of plants, animals, fungi and bacteria. For any pharmaceutical formulation the two main ingredients are active pharmaceutical ingredient and excipients. As excipients in any kind of dosage form, the biopolymers play a vital function. Biopolymers are pharmacologically inert ingredients formulated along with the active ingredient to increase the volume; they help in the formulating dosage form and also simultaneously can improve the physicochemical parameters of the dosage form and so are widely used in the development of new drug delivery system. The biopolymers which are obtained from animal sources are usually non-toxic, biocompatible, stable and economic; and can control the release pattern of the drug. Natural polymers have more preponderant effects on fast dissolving tablets than synthetic polymers. Now-a-days, because of many problems regarding drug release and adverse effects of synthetic polymers, manufacturers are going towards using natural polymers. In this review article we mainly discussed about types of polymer, different alignment of natural polymer, advantages of natural polymers over synthetic polymers, drawbacks of natural polymers, mechanism of drug release of polymer, different methods of preparation of biopolymers, role of polymer in pharmaceutical industry and drug delivery systems.

Keywords: Natural polymers, Chitin, Collagen, Sources, Preparation.
Efficacy of Whole-Body versus Lesional Application of Permethrin Cream for Scabies Treatment: A Quasi-Experimental Study
Authors: Sungkar Saleha , Haswinzky Rose A. , Dwinastiti Yasmine A. , Wardhana Aji W. , Irmawati Fanny P. , Kekalih Aria , Widaty Sandra
Published: March 2021

Objective: The study aims to evaluate the efficacy of whole-body versus lesional application of 5% permethrin cream for scabies eradication.

Design: This quasi-experimental study was conducted on September-October 2018 at boarding schools in Bogor and East Jakarta, Indonesia. Subjects were randomized into two groups, 51 students each.

Interventions: The first group received a whole-body application while the second group received lesional application of 5% permethrin cream. Evaluation was performed after 7 and 28 days.

Main outcome measures: Proportion of lesions cured following the intervention

Results: The prevalence of scabies was 41% and 33% at the boarding schools in Bogor and East Jakarta, respectively. Subjects from both groups had similar lesion distributions at baseline (p>0.05). Following intervention, the number of lesions reduced significantly (p<0.001) and both treatments were equally effective in treating scabies with 84.6% vs 91.5% cure rate [Relative Risk (RR) 1.8(0.6-5.0); p>0.05].

Conclusion: Lesional application of 5% permethrin is proven to be equally effective in treating scabies with higher cure rate. This method shows advantage for scabies treatment. In addition to reduce the unwanted side effects, it is more cost-effective and convenient. Further studies with larger sample size and randomized controlled trial design are warranted.

Keywords: scabies, permethrin, whole-body application, lesional application, cure rate
تطبيق طريقة رتلّي ستوري بالرسوم المتسلسلة لترقية قدرة الطلبة على مهارة الكلام دراسة تجريبية بـــباب النجاح بندا أتشية
Authors: Nurdiyani Nurdiyani  , Buhori Muslim
Published: March 2021

In the second language, speaking is a basic skill in learning language, because language it selft is speech, a person not considered of mastering the language except by mastering the speaking. The students of Babun Najah not only found difficult in speaking Arabic language but got borred as well. Thus, student had a very low ability. It was caused by the disagreement between method used by teacher and do not use the interesting media according to students’ condition, it makes the students felt bored, lack of attention to the subject; even some of them spoke during the teaching and learning process. So the learning process runs ineffectively. This resulted in the limit ability of students to speak Arabic. Based on this problem that has been studied by the researchers, so we need for solution to overcome these problems, including: applying the Retelling Story method with the serial images in teaching Arabic language to reach the purposes of teaching speaking skills, in hopes of increasing student ability in speaking skills by combining these two variables. The purposed of this research is to know students’ responses to speaking skills and students’ abilities in speaking Arabic language using the retelling method and serial pictures in Babun Najah Banda Aceh boarding school. Quantitative supported by qualitative approach along with experimental method was used by the researcher. Purposive sampling was used to find the second graders of II-C as a control class and II-D as an experimental class that was consisted of 23 students. The results are that students’ response toward Retelling story Method with the pictures series is well, and the use of Retelling story Method with the pictures series was effective and it gave a good impact on students of  Babun Najah Banda Aceh boarding school, which the result from the t-test relate calculation is greater than t-table result, that is 1,69 < 1,93.
Partial Purification and Biochemical Characterization of Horse Gram Arginase
Authors: Siddappa Shiva , Assefa Semira Shimeles , Nuthan Bettadapura Rameshgowda , Marathe Gopal Kedihithlu
Published: March 2021

Plant arginase that catalyses the hydrolysis of arginine to ornithine and urea is known to play an important role in nitrogen metabolism. Recently, we reported a highly stable arginase from cilantro and its sensitivity to biotic and abiotic stress. During this investigation, we found horse gram also possessing a stable arginase among legumes. Hence, we partially purified arginase from horse gram seedlings by conventional chromatographic techniques with 869-fold purity, and a specific activity of 13752 nmoles of urea formed/mg of protein/min. The enzyme is relatively heat stable and requires Mn2+ for its activity and is sensitive to reducing agents and EDTA similar to cilantro arginase. The optimum pH and temperature for partially purified horse gram arginase was found to be 7.87 and 37° C - 60° C respectively. Arginine-derived polyamines and amino acids can regulate horse gram arginase in vitro. Partially purified arginase hydrolyses L-arginine and is incapable of hydrolysing other arginine analogues except L-homoarginine, a property that distinguishes horse gram arginase from cilantro arginase. The Km for partially purified arginase was found to be 5.47 ± 0.34 mM with respect to L-arginine. As plant arginases are not stable and their subunit organization differs from source to source, for further purification and biochemical characterization horse gram serves as an ideal and easily available source.
Editorial - Revista de Doutrina e Jurisprudência - RDJ
Authors: Dias Carmelita Indiano Americano do Brasil
Published: March 2021

A Revista de Doutrina e Jurisprudência – RDJ do Tribunal de Justi-ça do Distrito Federal e dos Territórios – TJDFT comemora, em 2016, cin-quenta anos de existência.
RECUPERAÇÃO DE ATIVOS DESVIADOS POR CORRUPÇÃO: SOLUÇÕES INOVADORAS PARA LIDAR COM A CRIMINALIDADE ECONÔMICA
Authors: Saadi Ricardo Andrade , Machado Diogo de Oliveira
Published: March 2021

O artigo se dedica a explorar os valores patrimoniais e extrapatrimoniais envolvidos em casosde corrupção. A correlação entre tais valores permite a defesa de que a recuperação dos recursosdesviados por práticas ímprobas seja capaz de mitigar os efeitos deletérios do crime, sob a perspectivasocial, econômica e política. A complexidade do crime exige do Estado estratégias inovadoras paraenfrentá-lo de modo a, simultaneamente, desestimular a prática ilícita e reparar os danos deladecorrentes. Para tanto, o ordenamento jurídico nacional disponibiliza ferramentas de naturezapenal, civil e administrativa que, sem se confundirem, contribuem para uma abordagem abrangentede um problema que exige respostas sofisticadas. A comunidade internacional sugere o confisco debens como estratégia privilegiada para reagir à corrupção, por ser medida que afeta o lucro, objetivoprincipal do criminoso econômico. O confisco só será possível, contudo, caso se adotem medidascautelares para preservar o valor dos bens enquanto se desenvolve o respectivo processo judicial. Aconstrição temporária desses bens os leva à custódia do Estado, que assume a responsabilidade deadministrá-los de maneira economicamente eficiente, sob pena de sua intervenção significar oagravamento de uma situação já precária. O gerenciamento de bens é o tema central do artigo, queaborda os principais desafios para pensar soluções criativas e inovadoras de alcançar os melhoresresultados no enfrentamento à corrupção.
ATIVISMO JUDICIAL CAUSAS E FUNDAMENTOS
Authors: Rodrigues Ana Luíza de Morais
Published: March 2021

O ativismo judicial é tema que vem causando grandes divergências doutrinárias e originando constantestensões institucionais, especialmente entre Judiciário e Legislativo. Diante do caráter controvertido doassunto, o presente trabalho busca, por meio do contraste de posições doutrinárias paradigmáticas,elucidar as causas e os fundamentos do ativismo judicial, isto é: o contexto histórico, político e socialfavorável a esse fenômeno, assim como o conjunto de motivos racionalmente justificáveis com queseus defensores o fundamentam. Nesse percurso textual, lança-se mão de argumentos doutrináriosbrasileiros e estrangeiros, mormente da literatura norte-americana. Com isso, demonstrar-se-á que oativismo judicial revela nada mais do que uma postura legítima e necessária por parte do Poder Judiciário.
O EQUÍVOCO DO JUDICIÁRIO PERANTE A INEFICÁCIA DAS CESSÕES DE DIREITOS DE IMÓVEL PÚBLICO
Authors: Almeida Mara Silda Nunes de
Published: March 2021

O Distrito Federal tem grave problema de ocupação do solo com frequentes invasões de áreas públicase parcelamento irregular do solo, em total desrespeito às normas urbanísticas e ambientais, causandosérios prejuízos para a população local. A cessão de direitos tem sido frequentemente utilizada comoinstrumento para transferir imóveis, mas quando esse instrumento tem por objeto imóvel público, nãopossui nenhuma eficácia jurídica e, portanto, não assegura ao cessionário direito algum. Demonstraressa situação é um dos objetivos deste trabalho, que analisará também a indiscutível parcela deresponsabilidade que tem o Poder Judiciário na caótica situação fundiária da Capital federal, paraque, ao final, seja proposta uma reflexão do papel dos julgadores no sentido de contribuir para umacidade mais ordenada com meio ambiente saudável e equilibrado para a atual e futuras gerações. Otrabalho tem como campo de abordagem o direito público, o civil e a filosofia do direito e destina-se ademonstrar a falta de técnica no emprego do instituto da cessão de direitos e a parcela de contribuiçãodo Poder Judiciário para o problema da ocupação do solo no Distrito Federal.
A INTANGIBILIDADE DO MÓVEL TEMPORAL NA PROGRESSÃO DE REGIME
Authors: Silva Bruno Joviniano de Santana
Published: March 2021

O presente artigo aborda as repercussões da progressão de regime incidentes no lapso temporal.Discute-se a fixação do lapso temporal, sob a ótica do princípio da veracidade e legalidade, sobretudo,quando as decisões de progressão de regime são proferidas extemporaneamente, por culpa exclusivana demora da estrutura estatal. Traz-se à análise a questão sobre a inviabilidade da mobilidade domarco temporal, nas hipóteses de progressões de regime sucessivas. O campo de estudo é a populaçãocarcerária de Imperatriz do Maranhão, isto é, apenados que cumprem pena no regime fechado,semiaberto e aberto. A metodologia utilizada nesta pesquisa, é o método expositivo e discursivoconsistindo em exteriorização de ideias e uma abordagem crítica e opinativa sobre a temática.
IN(TER)DEPENDÊNCIA ENTRE DECISÕES JUDICIAIS E PARECERES PSICOSSOCIAIS NOS JUÍZOS CRIMINAIS: ANÁLISE QUANTITATIVA
Authors: Juras Mariana Martins , Said Amanda Pinheiro , Tusi Michelle Moreira de Abreu , Hamu Eneida Maria França e Silva
Published: March 2021

Em contexto de interface entre as áreas psicossociais e jurídicas, foi realizada pesquisa no Serviçode Assessoramento aos Juízos Criminais – SERAV no Tribunal de Justiça do Distrito Federal e dosTerritórios – TJDFT, cuja proposta foi relacionar os pareceres psicossociais com as decisões judiciaisde processos criminais cujas vítimas eram mulheres, crianças e adolescentes, a fim de analisar oimpacto dos pareceres no assessoramento aos juízes criminais durante o curso de processos referentesàs Leis 8.069/1990 e 11.340/2006. Realizou-se análise documental da amostra de 178 processos dosquais decorreram atendimentos no SERAV, em 2010. A maioria das decisões judiciais não acolheuas sugestões técnicas e/ou alusões de gravidade presentes nos pareceres psicossociais. O maiornúmero de acolhimentos deu-se para sugestões técnicas, especialmente as de encaminhamento dosjurisdicionados, sendo que houve maior acolhimento dos casos que envolviam crianças e adolescentes.Os resultados demonstraram, ainda, haver relação incipiente entre assessores e assessorados nosprocessos de violência doméstica e familiar contra mulheres, crianças e adolescentes.
A SOBERANIA ESTATAL: EVOLUÇÃO HISTÓRICA, DESENVOLVIMENTO NO BRASIL E PERSPECTIVAS ATUAIS
Authors: Santos Carolina Costa
Published: March 2021

A soberania estatal é um instituto jurídico que foi utilizado para que o Estado se sobrepusesse aosdemais elementos do seu território, bem como fosse reconhecido como portador dos mesmos direitosna ordem jurídica internacional. Da paz de Westfalia (1648) até a atualidade, a soberania estatal éreconhecida como um elemento essencial para o desenvolvimento e a afirmação do Estado. No Brasil,ela esteve presente em todas as suas Constituições, variando apenas de como era utilizada parafundamentar o poder estatal. Contudo, na atualidade, ela vem sendo duramente criticada, porque jánão resolve questões pontuais, fruto da globalização.
A IMPARCIALIDADE DO JUIZ
Authors: Lacerda Bruno Amaro
Published: March 2021

A imparcialidade é um valor ético de grande importância para os juristas, normalmente associado às ideias de justiça, igualdade e verdade. Este artigo objetiva mostrá-la como um dever que exige uma postura sensível e ativa do juiz, diferenciando-a da neutralidade ou indiferença quanto ao resultado do processo, mas destacando que a atuação imparcial deve ocorrer nos limites do ordenamento, sem subordinação a valores extrajurídicos oriundos de convicções políticas do julgador. Rejeitam-se, com isso, propostas de ativismo judicial que defendem ações exageradas de igualação ou mesmo a parcialidade “positiva” do juiz como método de solução das desigualdades sociais existentes.