bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Adherence to Physical Therapy in the Development of Serious Games: Conceptual Framework Design Study (Preprint)
Authors: Ambros-Antemate Jorge Fernando , Beristain-Colorado María del Pilar , Vargas-Treviño Marciano , Gutiérrez-Gutiérrez Jaime , Hernández-Cruz Pedro Antonio , Gallegos-Velasco Itandehui Belem , Moreno-Rodríguez Adriana
Published: November 2023

BACKGROUND

Insufficient levels of treatment adherence can have adverse effects on the outcomes of physical rehabilitation. To address this issue, alternative approaches to traditional therapies, such as serious games, have been designed to enhance adherence. Nevertheless, there remain gaps in the development of serious games concerning the effective implementation of motivation, engagement, and the enhancement of treatment adherence.

OBJECTIVE

This study aims to design a conceptual framework for the development of serious games that incorporate essential adherence factors to enhance patient compliance with physical rehabilitation programs.

METHODS

We formulated a conceptual framework using iterative techniques inspired by a conceptual framework analysis. Initially, we conducted a comprehensive literature review, concentrating on the critical adherence factors in physical rehabilitation. Subsequently, we identified, categorized, integrated, and synthesized the concepts derived from the literature review to construct the conceptual framework.

RESULTS

The framework resembles a road map, comprising 3 distinct phases. In the initial phase, the patient’s characteristics are identified through an initial exploration. The second phase involves the development of a serious game, with a focus on enhancing treatment adherence by integrating the key adherence factors identified. The third phase revolves around the evaluation of the serious game. These phases are underpinned by 2 overarching themes, namely, a user-centered design and the GameFlow model.

CONCLUSIONS

The conceptual framework offers a detailed, step-by-step guide for creating serious games that incorporate essential adherence factors, thereby contributing to improved adherence in the physical rehabilitation process. To establish its validity, further evaluations of this framework across various physical rehabilitation programs and user groups are necessary.
Use of Virtual Reality in Interdisciplinary Multimodal Pain Treatment With Insights From Health Care Professionals and Patients: Action Research Study (Preprint)
Authors: Ummels Darcy , Cnockaert Elise , Timmers Inge , den Hollander Marlies , Smeets Rob
Published: November 2023

BACKGROUND

Chronic pain is a widespread global health problem. Interdisciplinary multimodal pain treatment (IMPT) is a treatment option for people with chronic pain. Virtual reality (VR) could be used to broaden IMPT programs. However, despite the advantages of VR, it is rarely used in daily clinical practice.

OBJECTIVE

This research aimed to explore how, when, and with whom VR can be used meaningfully during IMPT, either as an addition or substitution as a component of IMPT.

METHODS

This research used an action research design to help health care professionals and patients learn how, when, and with whom they can use VR. Data were collected through reflection sessions with health care professionals and semistructured interviews with patients in 2 specialized centers that provide IMPT for chronic pain. Two researchers performed direct content analyses.

RESULTS

In total, 4 physiotherapists, 1 occupational therapist, 3 psychologists, and 22 patients participated in this research. Three iteration cycles, including 9 reflection sessions and 8 semistructured interviews, were performed. Both health care professionals and patients considered VR to be useful in therapy as an addition but not a substitution. VR was used as a diagnostic and intervention tool with all patients at the rehabilitation center or home. VR was used to gain insight into patients’ pain beliefs, cognitions, and irrational cognitions about additional damage and physical abilities. Considering VR as an intervention tool, the health care professionals had 3 goals: balancing relaxation and competition, grading activities, and exposure in vivo.

CONCLUSIONS

VR could be a valuable addition to IMPT for both patients with chronic pain and health care professionals. More research should be performed to assess the additional effects of VR on patients’ participation in daily life.
Active Tuberculosis Screening via a Mobile Health App in Myanmar: Incremental Cost-Effectiveness Evaluation (Preprint)
Authors: Htet Kyaw Ko Ko , Phyu Aye Nyein , Zayar Nyi Nyi , Chongsuvivatwong Virasakdi
Published: November 2023

BACKGROUND

A mobile app that calculates a tuberculosis (TB) risk score based on individual social and pathological characteristics has been shown to be a better predictor of the risk of contracting TB than conventionally used TB signs and symptoms (TBSS) in Myanmar, where the TB burden is high. Its cost-effectiveness, however, has not yet been assessed.

OBJECTIVE

This study aimed to determine the incremental costs of this mobile app and of chest x-rays (CXRs) in averting disability-adjusted life years (DALYs) among missed cases of active TB in the population being screened.

METHODS

Elements of incremental costs and effectiveness of 3 initial TB screening strategies were examined, including TBSS followed by CXR, the mobile app followed by CXR, and universal CXR. The incremental cost-effectiveness ratio (ICER; ie, the additional cost for each additional DALY averted) was compared to TBSS screening. Based on the latest 2020 gross domestic product (GDP) per capita of Myanmar (US $1477.50), the ICER was compared to willingness-to-pay (WTP) thresholds of 1, 2, and 3 times the GDP per capita. Probabilistic sensitivity analysis was conducted with a Monte Carlo simulation to compute the levels of probability that the ICER for each strategy was below each WTP threshold.

RESULTS

For each 100,000 population, the incremental cost compared to TBSS of active TB screening was US $345,942 for the mobile app and US $1,810,712 for universal CXR. The incremental effectiveness was 325 DALYs averted for the mobile app and 576 DALYs averted for universal CXR. For the mobile app, the estimated ICER was US $1064 (72% of GDP per capita) per 1 DALY averted. Furthermore, 100% of the simulated values were below an additional cost of 1 times the GDP per capita for 1 additional DALY averted. The universal CXR strategy has an estimated ICER of US $3143 (2.1 times the GDP per capita) per 1 DALY averted and an additional 77.2% DALYs averted compared to the app (ie, 576 – 325 / 325 DALYs); however, 0.5% of the simulated values were higher than an additional expenditure of 3 times the GDP per capita.

CONCLUSIONS

Based on the status of the economy in 2020, the mobile app strategy is affordable for Myanmar. The universal CXR strategy, although it could prevent an additional 77% of DALYs, is probably unaffordable. Compared to the TBSS strategy, the mobile app system based on social and pathological characteristics of TB has potential as a TB screening tool to identify missing TB cases and to reduce TB morbidity and mortality, thereby helping to achieve the global goal of “End TB” in resource-limited settings with a high TB burden.
Energy Characteristics of Clonal Teak Logging Waste from Paliyan-Gunungkidul, Indonesia
Authors: Irawati Denny , Nur Cahyo Aditya , Dian Yusi , Sulistyo Joko , Sunarta Sigit , Pujiarti Rini , Lukmandaru Ganis , Sutapa Johanes
Published: November 2023

Breeding teak with a clonal system was a common practice to enhance productivity and reduce rotation. A private company in Paliyan Sub-District, Gunungkidul Regency, Indonesia, developed Jati Unggul Nusantara (JUN) through vegetative propagation, particularly cloning, using cuttings. JUN had gained widespread popularity as a replacement for conventional teak varieties for commercial purposes. The utilization of JUN commercial timber left various non-commercial biomass forms, such as leaves, branches, and twigs. This research aimed to assess JUN logging waste biomass's energy potential and characteristics across different tree-age stands. This research used non-commercial biomass from six- and eight-year-old trees, including branches, twigs, leaves, stumps, and unmerchantable top stems. The results showed that the average dry weight of JUN logging waste from six- and eight-year-old trees was 31.5 and 53.5 kg/tree, while the calorific value ranged from 4516.4–5177.7 cal/g. This waste had good characteristics as an energy material, specifically from the part of unmerchantable top stems with a high fuelwood value indexof 6579.6.
APPLICATION OF HYBRID DIBR-FUCOM-LMAW-BONFERRONI-GREY-EDAS MODEL IN MULTICRITERIA DECISION-MAKING
Authors: Radovanović Marko , Božanić Darko , Tešić Duško , Puška Adis , Hezam Ibrahim M. , Jana Chiranjibe
Published: November 2023

The selection of unmanned aerial vehicles for different purposes is a frequent topic of research. This paper presents a hybrid model of an unmanned aerial vehicle (UAV) selection using the Defining Interrelationships Between Ranked criteria (DIBR), Full Consistency Method (FUCOM), Logarithm Methodology of Additive Weights (LMAW) and grey - Evaluation based on Distance from Average Solution (G-EDAS) methods. The above-mentioned model is tested and confirmed in a case study. First of all, in the paper are defined the criteria conditioning the selection, and then with the help of experts and by applying the DIBR, FUCOM and LMAW methods, the weight coefficients of the criteria are determined. The final values of the weight coefficients are obtained by aggregating the values of the criteria weights from all the three methods using the Bonferroni aggregator. Ranking and selection of the optimal UAV from twenty-three defined alternatives is carried out using the G-EDAS method. Sensitivity analysis confirmed a high degree of consistency of the solutions obtained using other MCDM methods, as well as changing the criteria weight coefficients. The proposed model has proved to be stable; its application is also possible in other areas and it is a reliable tool for decision-makers during the selection process.
ASSESSMENT OF SUSTAINABLE WASTEWATER TREATMENT TECHNOLOGIES USING INTERVAL-VALUED INTUITIONISTIC FUZZY DISTANCE MEASURE-BASED MAIRCA METHOD
Authors: Mishra Arunodaya Raj , Rani Pratibha , Cavallaro Fausto , Alrasheedi Adel Fahad
Published: November 2023

Effective wastewater treatment has significant effects on saving water and preventing unnecessary water scarcity. An appropriate wastewater treatment technology (WWTT) brings economic benefits through reuse in different sectors and benefits the society and environment. This study aims to develop a decision-making framework for evaluating the sustainable WWTTs under interval-valued intuitionistic fuzzy set (IVIFS) environment. The proposed MCDM framework is divided into two stages. First, a new Hellinger distance measure is developed to determine the degree of difference between IVIFSs and also discussed its desirable characteristics. Second, an interval-valued intuitionistic fuzzy extension of multi-attribute ideal-real comparative analysis (MAIRCA) model is developed using the proposed Hellinger distance measure-based weighting tool. Further, the proposed model is implemented on an empirical study of sustainable WWTTs evaluation problem. Sensitivity and comparative studies are made. The results indicate that odor impacts, sludge production, maintenance and operation are the most effective sustainable factors and Microbial fuel cell (MFC) technology is the best WWTT followed by natural treatment methods.
Elena Poniatowska: Premio Internacional Carlos Fuentes a la Creación Literaria en el Idioma Español 2023
Authors: Poniatowska Elena
Published: November 2023

Hélène Elizabeth Louise Amélie Paula Dolores Poniatowska Amor ha entregado su vida a las letras y se ha dedicado a dar voz al pueblo. A sus 91 años, se considera a Elena Poniatowska como la escritora viva más importante de México. En el amplio recorrido de su obra ha desarrollado todos los géneros —crónica, ensayo, cuento, novela, poesía, teatro— y ampliado el ámbito de lo literario para incorporar la entrevista y el reportaje periodísticos. Ha escrito para todos los públicos, entre ellos niños y jóvenes. Su compromiso con las causas más justas, su acérrima defensa de los derechos humanos y de la diversidad cultural, su visión de la mujer y de México, están a la altura de su calidad literaria que encuentra con cada obra nuevas y nuevos lectores que la veneran.
Acercamiento zootécnico a la etnohistoria de los equinos durante la conquista de México-Tenochtitlan
Authors: Perezgrovas Garza Raúl Andrés
Published: November 2023

Objetivo: examinar la presencia y el contexto alrededor de los caballos en documentos coloniales novohispanos, utilizando una metodología multidisciplinaria (historia y zootecnia).
Diseño metodológico: se sistematizaron las descripciones en que aparecen estos animales, principalmente la crónica de Bernal Díaz del Castillo (testigo presencial), el Códice Florentino, el Mapa de México de 1550 y las Actas del Cabildo de la ciudad de México (1524-1630).
Resultados: se encontraron detalles de la participación de equinos en la Conquista (1519-1521) y su uso al inicio de la colonización; durante la Conquista, los pobladores nativos quedaron asustados al conocerlos, lo que fue utilizado por Hernán Cortés para triunfar en las batallas, utilizando astutas estrategias bélicas. Consta en las crónicas que caballos y aperos eran muy escasos, por lo que se cuidaban al máximo. Los mexicas también diseñaron estrategias para contrarrestar a los equinos, que sirvieron para expulsar a los españoles de Tenochtitlan, causando muchas muertes de soldados y caballos. Al caer el imperio de Moctezuma (agosto de 1521) dio comienzo la reconstrucción de la ciudad y los antiguos soldados se volvieron colonos. Los caballos se utilizaban para el traslado de los colonos españoles, pues labores agrícolas y transporte de mercancías se hacían con cargadores indígenas. El Cabildo de la ciudad dictó ordenanzas para regular actividades relacionadas a los equinos.
Limitaciones de la investigación: la información se encuentra dispersa en las crónicas y eso dificulta la búsqueda.
Hallazgos: el análisis etnozootécnico permite vislumbrar de manera más completa la participación de equinos en la Conquista y en la Colonia.
Validation of a measurement instrument to assess the 10 elements for successful organizational transformations in Colombia's Valle del Cauca region
Authors: Camacho Segura Jorge Francisco , Espinosa Torres Juan Carlos , Cruz Caicedo Luis Fernando , Carvajal Valli Alfonso , González Cabo Verena
Published: November 2023

The objective of this paper is to validate a measurement instrument based on a five-point Likert scale, which can be used to evaluate the implementation of the 10 Elements proposed for the success of organizational transformations in companies from diverse economic sectors in Colombia's Valle del Cauca region. This study was conducted in three stages: first, the design of the instrument, which included the 10 Elements (categorized into principals and basics) and 40 items (four for each element); second, the administration of the surveys to organizations; and finally, the statistical analysis that verified the reliability of the scale using specialized software, and validity through the work of discriminant and convergent statistics.

The findings of the study were satisfactory, as demonstrated through the various descriptive statistical indicators used. The results concluded that this instrument can serve as a basis for academic and professional studies interested in evaluating the management of organizational transformation projects.

Overall, this paper provides a thorough and reliable validation of the measurement instrument and its usefulness for evaluating the success of organizational transformations in Colombia's Valle del Cauca region.
La teoría homeostática presente en la medición de la satisfacción con la vida en México a través de un sistema de inferencia difuso
Authors: Ortigosa Hernández Mauricio
Published: November 2023

Se ha visto que las medidas económicas objetivas como el PIB no reflejan fielmente el bienestar de la sociedad. Por ello, se han utilizado otras mediciones subjetivas como la satisfacción con la vida, siendo éste el indicador principal del bienestar subjetivo que se examina por medio de la autoevaluación que hace la propia persona sobre su vida. Lo anterior ha dado lugar a la teoría homeostática. Esta teoría indica que la persona evalúa su nivel de satisfacción con su vida de forma positiva y en el sentido más general.  La respuesta que la persona manifiesta, refleja el nivel en el que opera el sistema homeostático como mecanismo de autorregulación para adaptarse ante variaciones del exterior. El objetivo de la presente investigación es mostrar la presencia de dicho sistema al medir la satisfacción con la vida a través de un método de inferencia difuso. Para lograr tal medición, se utiliza una parte de los datos publicados referentes al bienestar subjetivo que genera la encuesta BIARE Básico, gestionada por el Instituto Nacional de Estadística y Geografía (INEGI). Los valores numéricos de este proceso muestran un comportamiento estable y positivo, ilustrando con esto el principio de la homeostasis que rige dicha teoría
A Perusal of Phenolics Within Polar Peel Fractions of Malus domestica var Maharaji via Hyphenated Techniques Cum Anti-microbial with REMA and Tyrosinase Inhibitory Potential thereof
Authors: Shah Ashfaq Ahmad , Singh Shivangi , Saini Shubhika , Pundir Aarushi , Saxena Kushal , Gupta Amit
Published: November 2023

This study aims to scrutinize the phenolic secondary metabolites in the polar peel decocture of Malus domestica var Maharaji via hyphenated techniques along with the study of the antibacterial, anti-candida, and tyrosinase inhibitory potential of bioactive compound-rich fractions. Preliminary phenolics go over was performed together with thin layer chromatography before the polar decocture was subjected to hyphenated techniques. FTIR investigation revealed the C-O bonds as in phenols, O-H bond stretch, and vibrations of alcohols and carboxylic acids as well as portrayed the C-H and >C=O stretches among other functional groups all of which are representative of phenolic and polyphenolic compounds. GC-MS perusal demonstrated the presence of bioactive compounds like Quercetin (13.04%), Ascorbic acid (6.48%), p-Coumaric acid (6.17%), Caffeic acid (5.69 %), Mallic acid (5.44%), Apigenin (5.28%), Citric acid (5.15%), Gallic acid (4.38%), Cyanidin (3.52%), and Ferulic acid (3.51%). Kirby-Bauer method followed by the resazurin microtiter assay technique (REMA) for MIC/MBC against six MTCC bacterial strains and one yeast, all producing stubborn opportunistic infection in humans, was used to assess the antibacterial property of all the bioactive rich fractions. Some fractions comparatively revealed a good activity index (AI) against tested microbes. MIC concentrations for bacteria ranged from 15-24 mg/ml while a lower MBC value recorded was 18 mg/ml. Methanol fraction revealed significant tyrosinase inhibitory activity by revealing IC50 of 980.98 µg/ml when L-Tyrosine was substrate and IC50 of 830.68 µg/ml when L-DOPA was substrate when juxtaposed to standard kojic acid that revealed IC50 of 128.822 µg/ml when L-Tyrosine was substrate and IC50 of 149.43 µg/ml when L-DOPA was substrate. The bioactive compounds possessed by the fractions, may be synergistically, turned out to be more effective in the diphenolase reaction and kojic acid acts more effectively in the monophenolase one. It was inferred that peel phenolics of this malus variety have a lot of therapeutic potential in the context of bacterial infections and pigmentation disorders.
Prevalence of Carbapenem-Resistant Enterobacterales, Acinetobacter baumannii, and Pseudomonas aeruginosa in a Tertiary Care Hospital in Eastern India: A Pilot Study
Authors: Verma Gaurav , Nayak Subham Ravi , Jena Swetapadma , Panda Subhra Snigdha , Pattnaik Dipti , Praharaj A.K. , Singh Nipa
Published: November 2023

In recent years, a wide range of clinical infections are being caused by carbapenem-resistant Enterobacterales, Acinetobacter baumannii and Pseudomonas aeruginosa. This is a matter of great concern, as carbapenem-resistant infections have fewer treatment options. The Enterobacterales comprises a large group of bacterial species commonly causing infections in healthcare settings. The most common bacteria are Escherichia coli and Klebsiella pneumoniae, which can cause both nosocomial and community-acquired infections. This study aimed to determine the prevalence of carbapenem-resistant Enterobacterales, P. aeruginosa, and A. baumannii, in a tertiary care center in India. The study was conducted over a period of seven months, from May 2022 to November 2022. The specimens were processed at the Microbiology Laboratory of Kalinga Institute of Medical Sciences- Pradyumna Bal Memorial Hospital, Bhubaneswar. Standard procedures were used to process the clinical specimens brought to the laboratory. Carbapenem-resistant isolates were screened according to the CLSI 2022 guidelines. This study included 3,006 isolates of Enterobacterales, A. baumannii, and P. aeruginosa. Of these, 29.40% (n = 844) were found to be carbapenem resistant. The breakup is as follows: 689 (77.94%) were Enterobacterales, 108 (12.21%) were A. baumannii, and 87 (9.84%) were P. aeruginosa. Thus, our investigation revealed an overall prevalence of carbapenem-resistant Enterobacterales, A. baumannii, and P. aeruginosa of 29.40%, which corresponds to previous studies in India. Early patient screening, isolation, and contact prevention measures will help reduce infection transmission. Further, larger multi-centric studies are required to obtain a wider perspective regarding this issue.
Cost-Effective Resource Allocation and Optimization Strategies for Multi-Cloud Environments
Authors: Shevtekar Prof. S. S. , Kulkarni Shrinidhi , Talwara Hatim
Published: November 2023

Abstract: As organizations increasingly adopt multi-cloud strategies to leverage the benefits of multiple cloud service providers, the need for effective cost optimization becomes paramount. This research paper aims to explore and propose innovative approaches for optimizing costs in multi-cloud environments. The study will investigate resource allocation, workload placement, and performance optimization techniques, taking into account factors such as workload variability, service-level agreements (SLAs), and pricing models across different cloud providers. The objective is to develop cost-effective strategies that balance performance and cost across a heterogeneous cloud ecosystem, ultimately helping organizations make informed decisions in their multi-cloud deployments. This research topic addresses the growing interest in multi-cloud architectures and the associated challenges in managing costs while ensuring high-quality service delivery. It provides a valuable contribution to the field of cloud computing and cost optimization, which is increasingly crucial for businesses and enterprises seeking to maximize the benefits of cloud technology.
Business Initiatives among Expatriates: A Bibliometric Analysis
Authors: J Vishnunath , Vincent Dr. Sangeetha
Published: November 2023

Abstract: Business initiatives including entrepreneurship, start-ups are fast growing and dynamic academic research field with a long intellectual tradition. In academics it attracts scholars who have distinct background and theoretical frameworks with different levels of analyses and methodological orientations. The study aims to examine the extent of research conducted on materials by employing a bibliometric review and data mapping methodology. The use of bibliometrics is progressively expanding across various academic fields. Bibliometrics is particularly well-suited for science mapping, especially during a time when there is a growing emphasis on empirical contributions, resulting in extensive, fragmented, and contentious research streams. Science mapping can be challenging and cumbersome due to its multi-step nature, often necessitating the use of multiple and varied software tools. Research data on materials were obtained from Scopus database including business initiatives among expatriate for the world landscape during the period 1975 to 2023. The search methodology involves focusing on a specific subject area and using titles, keywords, and abstracts of the study materials. The mapping process is done using Rtool and VOSviewer. A total of 623 articles were found. The results showed that the most studied study material was in the 1975- 2023 range. This review can certainly provide a reference point for further research related to materials.
Toward a Big History 2.0: A brief position paper
Authors:   James Madison University, Henriques Gregg , Volk Tyler ,   New York University
Published: November 2023

We propose a “Big History 2.0” framework based on a time-by-complexity relationship that the two authors converge on, a synthesis from their prior independent work. In particular, the framework distinguishes a line of levels of combogenesis from quarks to culture, in contrast to patterns of emergence involving larger aggregates or groups. The framework identifies major transitions to novelty marked by innovations in general evolutionary dynamics (PVSR; propagation, variation, and selective retention), which have occurred multiple times following the Big Bang. As in Henriques’ Tree of Knowledge System, we take the Mind-Animal plane of dynamics as one of these major transitions because of the innovative PVSR-dynamics in the mindedness of animals. We note the need to simultaneously attend to patterns and processes of formation, and we describe avenues of further consideration that follow from this framework. This position paper has been improved and slightly expanded from the version originally presented to the Big History Research Group for general discussion on November 20, 2022.
Evolutionary Phases of Big History
Authors:   National Research University Higher School of Economics , Moscow Institute for Oriental Studies, Russian Academy of Sciences, Moscow, Grinin Leonid , Grinin Anton ,   Moscow State University
Published: November 2023

The present article is devoted to the issue of unity of laws, patterns and mechanisms of evolution at all its stages and levels of Big History and megaevolution. Despite the enormous differences between cosmic, planetological, chemical, biological, and social evolutions, there are many similarities. There are a lot of important and insightful works on the development of complexity in our Universe and in the course of Big History. Unfortunately, much less studies are devoted to analysis of universal similarities, patterns and rules within Big History. Mostly such research is focused on a few laws of Big History which are usually connected with development of complexity. However, laws in terms of the typological similarity of many patterns and rules in star-galaxy, planetological, chemical, biological and social phases of Big History, are of great importance. In the present article we will consider a number of such important similarities, which, in our opinion, clearly demonstrate the systemic-structural and functional-evolutionary unity of the world at its different levels and in different areas. The understanding of these similarities deepens our perception about all stages of Big History and its regularities, and leads us away from the false idea that social evolution in all aspects is different from the evolution of previous levels. In the first section our key goal is to give our own definitions of evolution which would cover as many variants of evolutionary changes as possible. In the second section we will try to give a rather voluminous and dialectical picture of the unfolding universal evolution instead of a short scheme: cosmic – biological – social. The notions of main and transitional phases of Big History are introduced; and the importance of its planetary and chemical phases is shown. In the third section we will show that one can reveal a number of similarities at all levels and phases of megaevolution, which can be generalized in universal laws, rules, mechanisms, patterns and principles of evolution. One should note that in fact none of the important laws and principles, not any of the important rules of evolution, have been ‘lost’ in the process of transition from lower to higher levels. They were only modified and became more complicated, and there also appeared some new principles and rules (and in retrospect one can see their rudiments at the lowest levels of evolution). Some of these laws and rules are described in this section. In the fourth section we will try to present some evolutionary and philosophical ideas that explain the profound similarity in the laws and patterns of megaevolution at all its levels and phases. In the conclusion we will discuss evolutionary and non-evolutionary matters.
Synthesizing Historical Research Leads to a Simple, Compatible, and Extensible Big History Framework and Periodization
Authors:   Argonne National Laboratory, LePoire David
Published: November 2023

Many questions remain unanswered regarding how Big History events should be organized and interpreted. For example, should Big History be divided into periods or processes, when it is clearly a complex process of simultaneous interacting processes? In such an uncertain environment, how are models constructed and evaluated? When we look at Big History, at what level of abstraction do we start? This paper gleans important insights from a number of historical papers to develop a consistent view of Big History. It is important to consider many aspects of an evolving system. For example, how does the evolving system 1) learn from its experiences in the environment; 2) extract energy and resources to combat the trend towards chaos and higher entropy; 3) organize itself at multiple levels to meet new challenges? Various traditional scholarly disciplines contribute to various aspects of Big History, including astronomy, geology, evolutionary biology, evolutionary anthropology, and the history of civilizations. This suggests a base framework of cosmic and terrestrial phases. The terrestrial phase saw the sequential evolution of life, humans, and civilization. Based on this framework, the various disciplines’ timelines are consolidated along with their dynamic systems models. This base framework is then expanded to include more details. This simple approach meets many criteria for an effective framework: it integrates with knowledge from other disciplines; it provides a simple, understandable model; it can be extended in detail with nested transitions; and it immediately expresses the acceleration of evolving complex adaptive systems (CAS). Similarly, proposed frameworks offer slightly different perspectives.
AVALIAÇÃO DO AÇO ABNT P20 USINADO POR EDM COM SOLUÇÃO AQUOSA DE OCTABORATO DE SÓDIO TETRAHIDRATADO COMO FONTE DE BORO
Authors: Moreira Santos Barbosa João Paulo , Da Silva Anderson Edson , Pedroso da Silva Sinval , Rodrigues da Silva Ernane
Published: November 2023

Este trabalho apresenta um estudo da usinagem do aço ABNT P20 realizado em uma máquina de Usinagem por Descargas Elétricas por Penetração (S-EDM) adaptada, utilizando cobre eletrolítico como eletrodo ferramenta e octaborato de sódio tetrahidratado (Na2B8O13.4H2O) como fonte de boro, diluído em água deionizada. As amostras foram preparadas com o uso de técnicas metalográficas para caracterização das camadas refundida e intermediária, que foram formadas após o processo. Para medição da espessura das camadas e verificação de alterações microestruturais e morfológicas, foram obtidas imagens utilizando microscopias óptica e eletrônica de varredura. A dureza das camadas foi medida por meio de ensaios de microdureza Vickers, e a presença de boretos foi verificada por meio de difração de raios X (DRX). Após a realização do processo S-EDM, foi verificado aumento de 112% e 92%, aproximadamente, no valor médio de microdureza Vickers das camadas refundida e intermediária, respectivamente, em relação ao material-base, fato que pode ser justificado pela presença das fases FeB e Fe2B obtidas por DRX.
Portada, créditos, evaluadores e índice
Authors: BARRÓN RUIZ DE LA CUESTA Alberto
Published: November 2023

Índice, créditos, revisores, evaludadores, portada, contraportada
UTILIZATION OF COASTAL AREAS AND SMALL ISLANDS
Authors: Ansory Ahmad , Hasibuan Melkisedek , Yudistira Yudistira , Manalu Omena
Published: November 2023

Indonesia, as an archipelagic country with tens of thousands of islands and thousands of peer areas, should be our country can take advantage of the great gift of this condition. Our constitution shows that we must use natural resources for the most excellent welfare of society. However, at this time, it is inversely proportional to what we expect; regulation after regulation, we strive in the Management of these natural conditions, which, until now, the state of our country is just like that. So, the purpose of this writing is to discuss the view of the law as a legal norm in the Implementation of the management of coastal areas and small islands and what opportunities can be utilized by communities around coastal areas and small islands in their economic development and the sustainability of nature itself. The methodology we use is a normative juridical method; we want to discuss from a legal point of view how the rules apply and from some reliable literature that discusses the management and utilization of coastal areas and small islands.
LEGAL SOCIOLOGY OF LAND CONFLICT VS ORANG RIMBA’S LAND CONFLICT IN JAMBI PROVINCE
Authors: Ulma Riri Oktari , Rahmi Elita , Fitria Fitria , Pratiwi Cholillah Suci
Published: November 2023

The sociology of Orang Rimba Law, which portrays the issue of land conflict versus land conflict, is a crucial legal issue, even though so far, the Orang Rimba (Suku Anak Dalam) has been part of a beneficial symbiosis between Natural Resources and Human Resources (HR), because between the factors of mutual care between humans and nature, but in legal reality, land and land tenure in Indonesia,  The existence of the Orang Rimba institution as the original entity of the Malay tribe is a problem, because its living entity has been displaced by the laws of outsiders, namely the state and government, especially since the rolling of the issue of forest utilization through Forest Tenure Rights (HPH) and the use of forest products through legal entities whose ownership is by forest outsiders, plus natural disasters (forest fires) outsiders as people whom people have long feared as eating creatures human. The purpose of the study is to know the law in reality, especially society. Conclusion The Orang Rimba, as an indigenous entity in Jambi Province, must be brought to the attention of the local government. The right to life and other social rights, namely distinctive economic and cultural rights, must be fostered continuously so that their customary rights are protected from land grabs under the guise of plantations and forestry based on state approval of forests and non-forests and ignore the history of the Orang Rimba struggle which always maintains the forest ecosystem and its distinctive land and culture such as ritual rituals between man and nature to dispel nature's various kinds of anger against humans in the form of disasters, wrath, and even climate change, cultural mantras and dialects were developed by them, but have not been seen by Indonesian law as genuine and distinctive legal institutions.
The types of research data receiving scholarly credit within and across the science, engineering, and mathematics fields
Authors: (Corresponding Author) Hyoungjoo Park
Published: November 2023

This study examined the types of data that receive formal scholarly credit within and across the science, engineering, and mathematics (SEM) fields. The topics of whether data types are used in a way that encourages data reuse has not been actively studied. This study applied an exploratory method because formal data citation is a relatively new area. The Data Citation Index (DCI) of the Web of Science (WoS) was selected because the DCI provides a single access point to 400 data repositories worldwide across multiple disciplines. Nearly all citations were of quantitative data. The types that received the most credit were, in descending order, ribonucleic acid (RNA), crystal structure, protein sequence data, crystallographic data, Sequence Read Archive (SRA), genomic, images, nucleotide sequencing information, molecular structure, and crystallographic information, though citation was diverse across the various disciplines within these fields. In particular, qualitative data received no scholarly credit. This study contributes to better understanding of data types for data reuse.
A study on the election factors of ACM Fellow based on the co-authorship relationship
Authors: Zhou Hailing , Li Xiaole , (Corresponding Author) Jin Shi , Li Ming , Situ Lingyun
Published: November 2023

Most of past researches on successful scientist groups focused on the winners of international top-renowned awards. ACM Fellow as an academic honor of Computing Machinery field was rarely investigated. This article focuses on the research of the relationship between Fellows’ success and their co-authorship characteristics with previous Fellows. We selected a list of ACM Advanced Member Grades from 2015 to 2020 in 4 sub-domains as the empirical object, then set relevant indicators to indicate the cooperative relationship to analyze the relationship between their cooperation with previous Fellows and whether they can successfully be awarded as Fellows according to the correlation analysis and binary logistic regression method. The results show that the existence of a cooperative relationship with the previous Fellow is indeed beneficial to the Fellow candidate's selection. The more previous Fellows a candidate works with, the better chance they have of being elected as a Fellow, but the co-growth fellows are the main factor. Moreover, during the cooperation period, the total amount of the candidates’ own publications and the more their own contributions in the cooperation, the more conducive to success. Our results reflect a possible closing of the Fellowship circle, but also correct for biases about honorary award opportunism.
Medical Students’ Knowledge and Perceptions of Mpox in a High Incidence Region: Implications for Clinical Preparedness
Authors: Nusynowitz Jake , Jamneshan Lily , Garba Nana Aisha , Samuels Marquita , Bhoite Prasad , Stumbar Sarah E.
Published: November 2023

Introduction: In August 2022, mpox (formerly “monkeypox”) was declared a public health emergency in the United States, yet there has been little published on medical providers’ knowledge or perceptions of the disease. With one of the highest incidence rates in the United States being in South Florida, our Miami-based medical school aimed to assess students' perceived levels of knowledge and attitudes regarding mpox. 
Methods: An optional, anonymous survey consisting of multiple choice and Likert-type questions was emailed to all medical students. The first survey was sent out September 1, 2022, after which students received reminders on October 3, 8, and 31, 2022. We analyzed respondents’ perceived knowledge and risk of contracting mpox by comparing responses between heterosexual and LGBTQ+ groups and preclinical and clinical groups. We used Mann-Whitney U or Kruskal Wallis tests for inferential statistical analysis.
Results: Of 480 medical students, 168 (35.0%) responded to the survey. Most respondents (88.1%) were not concerned about mpox; 95.2% perceived their personal risk to be moderate or low. LGBTQ+ students were significantly more likely than others to report feeling at risk from mpox. The majority (72.0%) of respondents reported poor perceived knowledge of mpox. There was no significant difference between preclinical and clinical students' reported level of perceived knowledge (P=.0621); 76.2% of respondents were not confident in their ability to recognize mpox symptoms. LGBTQ+ students were significantly more confident in identifying symptoms than others (P=.0201).
Conclusion: Medical students feel they lack critical knowledge of mpox and report being unprepared to recognize disease symptoms. The higher level of perceived risk and knowledge among LGBTQ+ students may stem from biases perpetuated by public messaging regarding mpox. These findings highlight the need for integrating education on emerging epidemics into undergraduate medical education to enable students to safely provide high-quality patient care.
Dengue control in the state of goias-brazil using “wmel wolbachia”: a cost-effectiveness study
Authors: Barbosa Aurélio de Melo , Veronezi Rafaela Júlia Batista
Published: November 2023

Context: Dengue and other arboviruses have a considerable economic impact in Brazil. There are vector control strategies for dengue: traditional control with pesticides, Incompatible Insect Technique (IIT) with “wMel Wolbachia”, and Sterile Insect Technique (SIT). Objective: To analyze the cost-effectiveness ratio of the IIT/SIT strategy, compared to traditional vector control with pesticides, for dengue prevention from the perspective of the Brazilian Public Health System (BPHS) as the payer and from the societal perspective in the state of Goiás, Brazil.
Características e diagnóstico laboratorial das infecções causadas pelo hantavírus.
Authors: Paiva Felipe Augusto Matsuura , Cardoso Alessandra Marques
Published: November 2023

Introdução: A hantavirose é uma zoonose de distribuição mundial que utiliza como vetores roedores, musaranhos, toupeiras e morcegos. Os sintomas da infecção pelo hantavírus assemelham-se aos de diversas doenças, por isso o diagnóstico laboratorial é crucial para o tratamento precoce. Objetivo: O presente estudo objetivou realizar uma revisão da literatura sobre as características e diagnóstico laboratorial da hantavirose. Métodos: Trata-se de uma revisão integrativa da literatura com base no modelo PRISMA, com seleção de estudos nas bases de dados Portal de Periódicos da CAPES, PubMed/Medline, Scielo, ScienceDirect e Biblioteca Virtual em Saúde, empregando os descritores: hantavírus, diagnóstico laboratorial, exames e zoonose, em português e inglês, no período de 2015 a 2022. Resultados: Foram selecionados 18 artigos científicos que atendiam aos critérios de inclusão. Conclusão: Existe uma relação entre o meio ambiente e os reservatórios de hantavírus, ou seja, fatores ecológicos e antropogênicos exercem grande influência na ocorrência da hantavirose. O diagnóstico dessa doença é desafiador e requer investigação detalhada que inclua a sintomatologia do paciente, o histórico de exposição a animais reservatórios e os resultados de exames laboratoriais nas áreas de imunologia, biologia molecular, bioquímica e hematologia. Como desfechos negativos da hantavirose incluem-se a febre hemorrágica com síndrome renal, a síndrome pulmonar por hantavírus e o óbito.
Identifying Public Value of Zakat Management Organizations: A Review of Muzaki's Perception
Authors: Ansoriyah Faizatul , Kushandajani  , Hartuti Purnaweni  , Retno Sunu Astuti  , Son Haji
Published: November 2023

Zakat gain in Indonesia as the largest Muslim country in the world has not been compatible to its potential. The issuance of Law Number 23 of 2011 about Zakat management is the manifestation of Government’s attention to an attempt of maximizing zakat management. This study aims to analyze the public value of Zakat Managing Organization (Indonesian: Organisasi Pengelola Zakat or OPZ) viewed from muzaki’s perspective. The research method used was mix methods by analyzing the vision and mission of zakat managing organization and interviewing the zakat institution organizer, and using face-to-face questionnaire distributed to muzakis. The result of the research shows that there are some values identified for zakat managing organization: trustability (amanah), accountability, transparency, and synergy. Trust or trustability is intrinsic value, while accountability, transparency, and synergy are instrumental values.  The identified indicator of both intrinsic and instrumental values can be the basis for OPZ to consider muzakis’ need to maximize zakat management.
Zeaxanthin production by an Antarctic Flavobacterium sp.: Effect of dissolved oxygen concentration and modelling kinetics in batch and fed-batch fermentation
Authors: Vila Eugenia , Ferreira Jimena , Lareo Claudia , Saravia Verónica
Published: November 2023

Zeaxanthin is a high-value carotenoid, found naturally in fruits and
vegetables, flowers and microorganisms. Flavobacterium genera is
widely known for the production of zeaxanthin, in its free form.
Nowadays, the production of zeaxanthin from bacteria is still
non-competitive with traditional methods. The study of operational
conditions is a key aspect for scaling-up. In this work, the influence
of dissolved oxygen concentration was studied on zeaxanthin,
β-cryptoxanthin and β-carotene production. It was found
that 10% pO was the best condition for zeaxanthin
production in batch production, reaching a total carotenoids
concentration of 3280± 88 µg/L, with 86% of zeaxanthin
conversion. Biomass production, substrate consumption and total
carotenoid production kinetics were studied by analyzing carbon and
oxygen mass balances, as well as applying the Luedeking-Piret model. To
enhance carotenoid production, a fed-batch culture was performed in a
bioreactor. Although biomass productivity was similar to that in batch
mode, zeaxanthin productivity was higher in the batch conditions,
reaching 118 µg/Lh and 38 µg/Lh, respectively. The models
developed for batch cultures were tested to predict the behavior of the
fed-batch culture. A binary model, which considered glucose and oxygen
as limiting substrates, presented better results and exhibited a proper
fit.
Evaluating the mechanistic basis for the effects of novel magnesium alloys on osteoblast proliferation and adhesion
Authors: Liang Wenqiang , Yang Guoqing , Zhang Huaibin , Xie Ben , Li Qiangqiang , Wang Yongping
Published: November 2023

To explore the effects of a novel magnesium alloy
(Mg-3Nd-1Gd-0.3Sr-0.2Zn-0.4Zr (wt%)) on osteoblast proliferation and
adhesion, and to clarify the underlying molecular mechanisms. In vitro
DAPI and ALP analyses revealed that the new magnesium alloy was able to
promote osteoblast adhesion in a dose-dependent manner. CCK-8 assays
also revealed alloy-dependent changes in MC3T3-E1 cell proliferation
after 1, 3, 5, and 7 days, with significantly higher proliferation
levels in the group treated with the magnesium alloy leaching solution
(P<0.05). This new magnesium alloy was also able to enhance
fibronectin, collagen type I, integrin α2, FAK, and GLUT3 expression at
the mRNA and protein levels, driving MC3T3-E1 cell proliferation and
adhesion via the ERK and FAK/Akt/mTOR pathways. Consistent with the
observation, the addition of inhibitors specific for these pathways was
sufficient to disrupt the adhesion and proliferation of these MC3T3-E1
cells. Relative to titanium alloys, the new magnesium alloy developed in
this study was better able to promote MC3T3-E1 cell proliferation and
adhesion through the ERK and FAK/Akt/mTOR signaling pathways,
respectively.