bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease
Authors: Ahmed Tarek A. , El-Say Khalid M. , Abd-Allah Fathy I. , Omar Abdelsattar M. , El-Araby Moustafa E. , Muhammad Yosra A. , Pagare Piyusha P. , Zhang Yan , Mohmmad Khadijah A. , Abdulmalik Osheiza , Safo Martin K.
Published: July 2021

Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolinate (PP10) is another promising aromatic aldehyde, recently reported by our group. Like voxelotor, PP10 exhibits O2-dependent antisickling activity, but, unlike voxelotor, PP10 shows unique O2-independent antisickling effect. PP10, however, has limited solubility. This study therefore aimed to develop oral and parenteral formulations to improve PP10 solubility and bioavailability. Methods: Oral drug tablets with 2-hydroxypropyl beta cyclodextrin (HP-β-CD), polyvinylpyrrolidone, or Eudragit L100-55 PP10-binary system, and an intravenous (IV) formulation with d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or HP-β-CD, were developed. The pharmacokinetic behavior of the formulations was studied in Sprague-Dawley rats. PP10, a methylester, and its acid metabolite were also studied in vitro with sickle whole blood to determine their effect on Hb modification, Hb oxygen affinity, and sickle red blood cell inhibition. Results: Aqueous solubility of PP10 was enhanced ~5 times with the HP-β-CD binary system, while the TPGS aqueous micelle formulation was superior, with a drug concentration of 0.502 ± 0.01 mg/mL and a particle size of 26 ± 3 nm. The oral tablets showed relative and absolute bioavailabilities of 173.4% and 106.34%, respectively. The acid form of PP10 appeared to dominate in vivo, although both PP10 forms demonstrated pharmacologic effect. Conclusion: Oral and IV formulations of PP10 were successfully developed using HP-β-CD binary system and TPGS aqueous micelles, respectively, resulting in significantly improved solubility and bioavailability.
Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous Solid Dispersions
Authors: Thakkar Rishi , Jara Miguel O. , Swinnea Steve , Pillai Amit R. , Maniruzzaman Mohammed
Published: July 2021

This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step manufacturing of ASD is possible using selective laser sintering 3D printing processes, however, the mechanism of ASD formation by this process is not completely understood and it requires further investigation. We hypothesize that the mechanism of ASD formation is the diffusion and dissolution of the drug in the polymeric carrier during the selective laser sintering (SLS) process and the drug particle size plays a critical role in the formation of said ASDs as there is no mixing involved in the sintering process. Herein, indomethacin was used as a model drug and introduced into the feedstock (Kollidon® VA64 and Candurin® blend) as either unprocessed drug crystals (particle size > 50 µm) or processed hot-melt extruded granules (DosePlus) with reduced drug particle size (<5 µm). These feedstocks were processed at 50, 75, and 100 mm/s scan speed using SLS 3D printing process. Characterization and performance testing were conducted on these tablets which revealed the amorphous conversion of the drug. Both MANOVA and ANOVA analyses depicted that the laser speed and drug particle size significantly impact the drug’s apparent solubility and drug release. This significant difference in performance between formulations is attributed to the difference in the extent of dissolution of the drug in the polymeric matrix, leading to residual crystallinity, which is detrimental to ASD’s performance. These results demonstrate the influence of drug particle size on solid-state and performance of 3D printed solid dispersions, and, hence, provide a better understanding of the mechanism and limitations of SLS 3D printing of ASDs and its dosage forms.
Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells
Authors: Hyun Jiyu , Im Jisoo , Kim Sung-Won , Kim Han Young , Seo Inwoo , Bhang Suk Ho
Published: July 2021

Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of Morus alba activates β-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with M. alba root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of β-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.
No Time Dependence of Ciprofloxacin Pharmacokinetics in Critically Ill Adults: Comparison of Individual and Population Analyses
Authors: Šíma Martin , Michaličková Danica , Ryšánek Pavel , Cihlářová Petra , Kuchař Martin , Lžičařová Daniela , Beroušek Jan , Hartinger Jan Miroslav , Vymazal Tomáš , Slanař Ondřej
Published: July 2021

The aim of this prospective PK study was to evaluate the pharmacokinetics of ciprofloxacin dosed within the first 36 h (early phase) and after 3 days of treatment (delayed phase) using individual and population PK analysis. The secondary aim of the study was to evaluate possible dosing implications of the observed PK differences between early and delayed phases to achieve a PK/PD target for ciprofloxacin of AUC24/MIC ≥ 125. Blood concentrations of ciprofloxacin (1 and 4 h after dose and trough) were monitored in critically ill adults in the early and delayed phases of the treatment. Individual and population PK analyses were performed. Complete concentration-time profiles in the early phase, delayed phase, and both phases were obtained from 29, 15, and 14 patients, respectively. No systematic changes in ciprofloxacin PK parameters between the early and delayed phases were observed, although variability was higher at the early phase. Both individual and population analyses provided similar results. Simulations showed that after standard dosing, it is practically impossible to reach the recommended ciprofloxacin PK/PD target (AUC/MIC ≥ 125) for pathogens with MIC ≥ 0.5 mg/L. A dosing nomogram utilizing patients’ creatinine clearance and MIC values was constructed. Both individual and population analyses provided similar results. Therapeutic drug monitoring should be implemented to safeguard the optimal ciprofloxacin exposure.
Advantages and Disadvantages of Using Magnetic Nanoparticles for the Treatment of Complicated Ocular Disorders
Authors: Schneider-Futschik Elena K. , Reyes-Ortega Felisa
Published: July 2021

Nanomaterials provide enormous opportunities to overcome the limitations of conventional ocular delivery systems, such as low therapeutic efficacy, side effects due to the systemic exposure, or invasive surgery. Apart from the more common ocular disorders, there are some genetic diseases, such as cystic fibrosis, that develop ocular disorders as secondary effects as long as the disease progresses. These patients are more difficult to be pharmacologically treated using conventional drug routes (topically, systemic), since specific pharmacological formulations can be incompatible, display increased toxicity, or their therapeutic efficacy decreases with the administration of different kind of chemical molecules. Magnetic nanoparticles can be used as potent drug carriers and magnetic hyperthermia agents due to their response to an external magnetic field. Drugs can be concentrated in the target point, limiting the damage to other tissues. The other advantage of these magnetic nanoparticles is that they can act as magnetic resonance imaging agents, allowing the detection of the exact location of the disease. However, there are some drawbacks related to their use in drug delivery, such as the limitation to maintain efficacy in the target organ once the magnetic field is removed from outside. Another disadvantage is the difficulty in maintaining the therapeutic action in three dimensions inside the human body. This review summarizes all the application possibilities related to magnetic nanoparticles in ocular diseases.
Anticancer Diiron Vinyliminium Complexes: A Structure–Activity Relationship Study
Authors: Braccini Simona , Rizzi Giorgia , Biancalana Lorenzo , Pratesi Alessandro , Zacchini Stefano , Pampaloni Guido , Chiellini Federica , Marchetti Fabio
Published: July 2021

A series of 16 novel diiron complexes of general formula [Fe2Cp2(CO)(μ-CO){μ-η1:η3-C(R′)C(R″)CN(R)(Y)}]CF3SO3 (2–7), bearing different substituents on the bridging vinyliminium ligand, was synthesized in 69–95% yields from the reactions of diiron μ-aminocarbyne precursors with various alkynes. The products were characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy; moreover the X-ray structures of 2c (R = Y = CH2Ph, R′ = R″ = Me) and 3a (R = CH2CH=CH2, Y = R′ = Me, R″ = H) were ascertained by single-crystal X-ray diffraction studies. NMR and UV–Vis methods were used to assess the D2O solubility, the stability in aqueous solution at 37 °C and the octanol–water partition coefficients of the complexes. A screening study evidenced a potent cytotoxicity of 2–7 against the A2780 cancer cell line, with a remarkable selectivity compared to the nontumoral Balb/3T3 cell line; complex 4c (R = Cy, Y = R′ = R″ = Me) revealed as the most performant of the series. The antiproliferative activity of a selection of complexes was also assessed on the cisplatin-resistant A2780cisR cancer cell line, and these complexes were capable of inducing a significant ROS production. Moreover, ESI-MS experiments indicated the absence of interaction of selected complexes with cytochrome c and the potentiality to inhibit the thioredoxin reductase enzyme (TrxR).
Multipurpose Prevention Technologies: Oral, Parenteral, and Vaginal Dosage Forms for Prevention of HIV/STIs and Unplanned Pregnancy
Authors: Young Isabella C. , Benhabbour Soumya Rahima
Published: July 2021

There is a high global prevalence of HIV, sexually transmitted infections (STIs), and unplanned pregnancies. Current preventative daily oral dosing regimens can be ineffective due to low patient adherence. Sustained release delivery systems in conjunction with multipurpose prevention technologies (MPTs) can reduce high rates of HIV/STIs and unplanned pregnancies in an all-in-one efficacious, acceptable, and easily accessible technology to allow for prolonged release of antivirals and contraceptives. The concept and development of MPTs have greatly progressed over the past decade and demonstrate efficacious technologies that are user-accepted with potentially high adherence. This review gives a comprehensive overview of the latest oral, parenteral, and vaginally delivered MPTs in development as well as drug delivery formulations with the potential to advance as an MPT, and implementation studies regarding MPT user acceptability and adherence. Furthermore, there is a focus on MPT intravaginal rings emphasizing injection molding and hot-melt extrusion manufacturing limitations and emerging fabrication advancements. Lastly, formulation development considerations and limitations are discussed, such as nonhormonal contraceptive considerations, challenges with achieving a stable coformulation of multiple drugs, achieving sustained and controlled drug release, limiting drug–drug interactions, and advancing past preclinical development stages. Despite the challenges in the MPT landscape, these technologies demonstrate the potential to bridge gaps in preventative sexual and reproductive health care.
Surface Characterization and Physiochemical Evaluation of P(3HB-co-4HB)-Collagen Peptide Scaffolds with Silver Sulfadiazine as Antimicrobial Agent for Potential Infection-Resistance Biomaterial
Authors: Vigneswari Sevakumaran , Gurusamy Tana Poorani , Khairul Wan M. , H.P.S. Abdul Khalil , Ramakrishna Seeram , Amirul Al-Ashraf Abdullah
Published: July 2021

Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial derived biopolymer widely known for its unique physical and mechanical properties to be used in biomedical application. In this study, antimicrobial agent silver sulfadiazine (SSD) coat/collagen peptide coat-P(3HB-co-4HB) (SCCC) and SSD blend/collagen peptide coat-P(3HB-co-4HB) scaffolds (SBCC) were fabricated using a green salt leaching technique combined with freeze-drying. This was then followed by the incorporation of collagen peptides at various concentrations (2.5–12.5 wt.%) to P(3HB-co-4HB) using collagen-coating. As a result, two types of P(3HB-co-4HB) scaffolds were fabricated, including SCCC and SBCC scaffolds. The increasing concentrations of collagen peptides from 2.5 wt.% to 12.5 wt.% exhibited a decline in their porosity. The wettability and hydrophilicity increased as the concentration of collagen peptides in the scaffolds increased. In terms of the cytotoxic results, MTS assay demonstrated the L929 fibroblast scaffolds adhered well to the fabricated scaffolds. The 10 wt.% collagen peptides coated SCCC and SBCC scaffolds displayed highest cell proliferation rate. The antimicrobial analysis of the fabricated scaffolds exhibited 100% inhibition towards various pathogenic microorganisms. However, the SCCC scaffold exhibited 100% inhibition between 12 and 24 h, but the SBCC scaffolds with SSD impregnated in the scaffold had controlled release of the antimicrobial agent. Thus, this study will elucidate the surface interface-cell interactions of the SSD-P(3HB-co-4HB)-collagen peptide scaffolds and controlled release of SSD, antimicrobial agent.
Poly(Alkylene 2,5-Thiophenedicarboxylate) Polyesters: A New Class of Bio-Based High-Performance Polymers for Sustainable Packaging
Authors: Guidotti Giulia , Soccio Michelina , Gazzano Massimo , Siracusa Valentina , Lotti Nadia
Published: July 2021

In the present study, 100% bio-based polyesters of 2,5-thiophenedicarboxylic acid were synthesized via two-stage melt polycondensation using glycols containing 3 to 6 methylene groups. The so-prepared samples were characterised from the molecular point of view and processed into free-standing thin films. Afterward, both the purified powders and the films were subjected to structural and thermal characterisation. In the case of thin films, mechanical response and barrier properties to O2 and CO2 were also evaluated. From the results obtained, it emerged that the length of glycolic sub-units is an effective tool to modulate the chain mobility and, in turn, the kind and amount of ordered phases developed in the samples. In addition to the usual amorphous and 3D crystalline phases, in all the samples investigated it was possible to evidence a further phase characterised by a lower degree of order (mesophase) than the crystalline one, whose amount is strictly related to the glycol sub-unit length. The relative fraction of all these phases is responsible for the different mechanical and barrier performances. Last, but not least, a comparison between thiophene-based homopolymers and their furan-based homologues was carried out.
Photo- and Acid-Degradable Polyacylhydrazone–Doxorubicin Conjugates
Authors: Psarrou Maria , Kothri Martha Georgia , Vamvakaki Maria
Published: July 2021

Light-mediated polymer degradation has attracted considerable attention in various applications, including photo-patterning, tissue engineering and photo-triggered drug delivery. In this study, we report the synthesis and characterization of a new, linear, main-chain photo- and acid-degradable copolymer based on acylhydrazone linkages. The polymer was synthesized via a step-growth copolymerization of adipic acid dihydrazide with a bifunctional poly(ethylene glycol) bearing benzaldehyde end-groups, under mild acidic conditions, to afford a hydrophilic PEG-alt-adipic acid (PEG-alt-AA) alternating copolymer. The synthesized polymer was characterized by size exclusion chromatography, proton nuclear magnetic resonance and attenuated total reflection-Fourier transform infrared spectroscopies. The main-chain photo- and acid-induced degradation of the copolymer in dimethylsulfoxide and water, respectively, was verified by UV-vis spectroscopy at light intensities as low as 0.1 mW cm−2 at λ = 254 nm. Next, a model anticancer drug, doxorubicin (DOX), was chemically linked to the polymer chain end(s) via acylhydrazone bond(s), resulting in amphiphilic PEG-alt-adipic acid-DOX (PEG-alt-AA-DOX) polymer–drug conjugates. The conjugates were self-assembled in water to form spherical nanoparticles, as evidenced by scanning and transmission electron microscopies. The irradiation of the self-assembled PEG-alt-AA-DOX conjugates with UV light and the decrease of the solution pH resulted in the disruption of the assemblies due to the photolysis and acidolysis of the acylhydrazone bonds, and the release of the therapeutic cargo.
Decarbonising the Portland and Other Cements—Via Simultaneous Feedstock Recycling and Carbon Conversions Sans External Catalysts
Authors: Devasahayam Sheila
Published: July 2021

The current overarching global environmental crisis relates to high carbon footprint in cement production, waste plastic accumulation, and growing future energy demands. A simultaneous solution to the above crises was examined in this work. The present study focused on decarbonizing the calcination process of the cement making using waste plastics and biowastes as the reactants or the feedstock, to reduce the carbon footprint and to simultaneously convert it into clean energy, which were never reported before. Other studies reported the use of waste plastics and biowastes as fuel in cement kilns, applicable to the entire cement making process. Calcination of calcium carbonate and magnesium carbonate is the most emission intensive process in cement making in Portland cements and Novacem-like cements. In the Novacem process, which is based on magnesium oxide and magnesium carbonates systems, the carbon dioxide generated is recycled to carbonate magnesium silicates at elevated temperatures and pressures. The present study examined the Novacem-like cement system but in the presence of waste plastics and biomass during the calcination. The carbon dioxide and the methane produced during calcination were converted into syngas or hydrogen in Novacem-like cements. It was established that carbon dioxide and methane emissions were reduced by approximately 99% when plastics and biowastes were added as additives or feedstock during the calcination, which were converted into syngas and/or hydrogen. The reaction intermediates of calcination reactions (calcium carbonate–calcium oxide or magnesium carbonate–magnesium oxide systems) can facilitate the endothermic carbon conversion reactions to syngas or hydrogen acting as non-soot forming catalysts. The conventional catalysts used in carbon conversion reactions are expensive and susceptible to carbon fouling. Two criteria were established in this study: first, to reduce the carbon dioxide/methane emissions during calcination; second, to simultaneously convert the carbon dioxide and methane to hydrogen. Reduction and conversion of carbon dioxide and methane emissions were facilitated by co-gasification of plastics and bio-wastes.
Advances in Functionalized Photosensitive Polymeric Nanocarriers
Authors: Fernández Maritza , Orozco Jahir
Published: July 2021

The synthesis of light-responsive nanocarriers (LRNs) with a variety of surface functional groups and/or ligands has been intensively explored for space-temporal controlled cargo release. LRNs have been designed on demand for photodynamic-, photothermal-, chemo-, and radiotherapy, protected delivery of bioactive molecules, such as smart drug delivery systems and for theranostic duties. LRNs trigger the release of cargo by a light stimulus. The idea of modifying LRNs with different moieties and ligands search for site-specific cargo delivery imparting stealth effects and/or eliciting specific cellular interactions to improve the nanosystems’ safety and efficacy. This work reviews photoresponsive polymeric nanocarriers and photo-stimulation mechanisms, surface chemistry to link ligands and characterization of the resultant nanosystems. It summarizes the interesting biomedical applications of functionalized photo-controlled nanocarriers, highlighting the current challenges and opportunities of such high-performance photo-triggered delivery systems.
Recent Advances in Antioxidant Polymers: From Sustainable and Natural Monomers to Synthesis and Applications
Authors: Maraveas Chrysanthos , Bayer Ilker S. , Bartzanas Thomas
Published: July 2021

Advances in technology have led to the production of sustainable antioxidants and natural monomers for food packaging and targeted drug delivery applications. Of particular importance is the synthesis of lignin polymers, and graft polymers, dopamine, and polydopamine, inulin, quercetin, limonene, and vitamins, due to their free radical scavenging ability, chemical potency, ideal functional groups for polymerization, abundance in the natural environment, ease of production, and activation of biological mechanisms such as the inhibition of the cellular activation of various signaling pathways, including NF-κB and MAPK. The radical oxygen species are responsible for oxidative damage and increased susceptibility to cancer, cardiovascular, degenerative musculoskeletal, and neurodegenerative conditions and diabetes; such biological mechanisms are inhibited by both synthetic and naturally occurring antioxidants. The orientation of macromolecules in the presence of the plasticizing agent increases the suitability of quercetin in food packaging, while the commercial viability of terpenes in the replacement of existing non-renewable polymers is reinforced by the recyclability of the precursors (thyme, cannabis, and lemon, orange, mandarin) and marginal ecological effect and antioxidant properties. Emerging antioxidant nanoparticle polymers have a broad range of applications in tumor-targeted drug delivery, food fortification, biodegradation of synthetic polymers, and antimicrobial treatment and corrosion inhibition. The aim of the review is to present state-of-the-art polymers with intrinsic antioxidant properties, including synthesis scavenging activity, potential applications, and future directions. This review is distinct from other works given that it integrates different advances in antioxidant polymer synthesis and applications such as inulin, quercetin polymers, their conjugates, antioxidant-graft-polysaccharides, and polymerization vitamins and essential oils. One of the most comprehensive reviews of antioxidant polymers was published by Cirillo and Iemma in 2012. Since then, significant progress has been made in improving the synthesis, techniques, properties, and applications. The review builds upon existing research by presenting new findings that were excluded from previous reviews.
Bio-Polyurethane Foams Modified with a Mixture of Bio-Polyols of Different Chemical Structures
Authors: Prociak Aleksander , Kurańska Maria , Uram Katarzyna , Wójtowicz Monika
Published: July 2021

We report on rigid polyurethane (PUR) foams prepared using different contents of a mixture of two bio-polyols (20–40 php). The bio-polyols were obtained through epoxidation and a ring opening reaction. Different chemical structures of the bio-polyols resulted from the use of 1-hexanol and 1,6-hexanediol as opening agents. The bio-polyols were characterized by hydroxyl values of 104 and 250 mgKOH/g and viscosities of 643 and 5128 mPa·s, respectively. Next, the influence of the bio-polyols on the foaming process of PUR systems as well as the foam properties was evaluated. The bio-foams modified with different contents of the bio-polyols were next compared with a reference foam obtained using a polyether petrochemical polyol. The effect of the apparent density reduction as a result of replacing the petrochemical polyol was minimized by decreasing the water content in the formulation. It was found that the modification of the recipe by changing the content of water, acting as a chemical foaming agent, did not affect the foaming process. However, the introduction of the bio-polyols mixture limited the reactivity of the systems by reducing the maximum temperature of the foaming process. The bio-materials with comparable apparent densities to that of the reference material were characterized by similar values of the thermal conductivity coefficient and a decrease in their mechanical strengths. A deterioration of mechanical properties was caused by the plasticization of the polyurethane matrices with the bio-polyols containing dangling chains. However, all materials were dimensionally stable at room temperature.
Comprehensive Review of the Properties and Modifications of Carbon Fiber-Reinforced Thermoplastic Composites
Authors: Alshammari Basheer A. , Alsuhybani Mohammed S. , Almushaikeh Alaa M. , Alotaibi Bander M. , Alenad Asma M. , Alqahtani Naif B. , Alharbi Abdullah G.
Published: July 2021

Carbon fiber-reinforced polymers are considered a promising composite for many industrial applications including in the automation, renewable energy, and aerospace industries. They exhibit exceptional properties such as a high strength-to-weight ratio and high wear resistance and stiffness, which give them an advantage over other conventional materials such as metals. Various polymers can be used as matrices such as thermosetting, thermoplastic, and elastomers polymers. This comprehensive review focuses on carbon fiber-reinforced thermoplastic polymers due to the advantages of thermoplastic compared to thermosetting and elastomer polymers. These advantages include recyclability, ease of processability, flexibility, and shorter production time. The related properties such as strength, modulus, thermal conductivity, and stability, as well as electrical conductivity, are discussed in depth. Additionally, the modification techniques of the surface of carbon fiber, including the chemical and physical methods, are thoroughly explored. Overall, this review represents and summarizes the future prospective and research developments carried out on carbon fiber-reinforced thermoplastic polymers.
Islamic Perspectives on Organ Transplantation: A Continuous Debate
Authors: Ali Jan A.
Published: July 2021

From a medical perspective, as well as an ordinary human perspective, organ transplantation is often understood as a process through which health is restored to sick humans and, consequently, their quality of life improved. Organ transplantation is a medical surgical procedure carried out by an expert or a team of experts who remove a failing or diseased organ or organs from the human body and replace it or them with a functioning organ or organs. With such positive portrayal of the process, organ transplantation is highly recommended and encouraged in modern medicine. However, in Islam, the Qur’an and hadiths—the two great texts of the religion—are silent on the subject. In other words, there is no discussion of the subject in the texts and, therefore, it is not clear whether organ transplantation is permissible or not in Islam. Thus, is organ transplantation an accepted modality of treatment that eliminates the patient’s agony from end-stage organ failure, remains an open-ended question. Whilst some Muslim scholars and jurists argue in favour of organ donation and transplantation, there are others who reject the practice as a breach of shari’ah. This paper posits that the subject of organ donation and transplantation in Islam is an unresolved matter without a ubiquitous consensus. The purpose of the paper is to educate the readers about the two key perspectives on the subject, and highlight that more research and a robust academic and sociological debate are needed to resolve the question of organ donation and transplantation in Islam.
Underlying Topography Inversion Using TomoSAR Based on Non-Local Means for an L-Band Airborne Dataset
Authors: Peng Xing , Wang Youjun , Long Shilin , Pan Xiong , Xie Qinghua , Du Yanan , Fu Haiqiang , Zhu Jianjun , Li Xinwu
Published: July 2021

The underlying topography is an important part of the three-dimensional structure of forests, and is used for a variety of applications, such as hydrology and water resource management, civil engineering projects, and forest resource surveying. Due to the three-dimensional imaging ability and strong penetration, the tomographic synthetic aperture radar (TomoSAR) with a long wavelength has been shown to be a useful tool to estimate the underlying topography. At present, most of the current methods use the local means method to estimate the sample covariance matrix, in which the vertical backscattering power is estimated. However, these methods cannot easily obtain high-precision underlying topography, and often lose some detailed information. In this paper, to solve this problem, a non-local means method is introduced to estimate the optimal covariance matrix by combining weighted neighborhood pixels. To validate the feasibility and effectiveness of this proposed method, a BioSAR 2008 campaign L-band dataset acquired from the northern forests of Sweden was used to inverse the underlying topography. The results show that the accuracy of the underlying topography retrieved by the proposed method is improved by more than 30% when compared with the traditional method.
In-Reservoir Waveform Retrieval for Monitoring at Groningen—Seismic Interferometry with Active and Passive Deep Borehole Data
Authors: Akbar Muhammad F. , Vasconcelos Ivan , Paulssen Hanneke , Zhou Wen
Published: July 2021

The Groningen gas field in the Netherlands is an ideal test bed for in-situ reservoir monitoring techniques because of the availability of both active and passive in-reservoir seismic data. In this study, we use deconvolution interferometry to estimate the reflection and transmission response using active and passive borehole data within the reservoir at ∼3-km depth and separate up- and downgoing P- and S-wave fields by f-k filtering. We validate the results using synthetic data of a 1D elastic model built from sonic logs recorded in the well. The estimated full-waveform reflection response for a virtual source at the top geophone is consistent with the synthetic response. For the virtual source at the bottom geophone, the reflection response appears to be phase delayed, though its arrivals are consistent with the local subsurface geology. Similarly, the first-order estimated local transmission response successfully approximates that of the P-wave velocity in the reservoir. The study shows that reliable subsurface information can be obtained from borehole interferometry without detailed knowledge of the medium parameters. In addition, the method could be used for passive reservoir monitoring to detect velocity, attenuation, and/or interface time-lapse variations.
Development and Application of Earth Observation Based Machine Learning Methods for Characterizing Forest and Land Cover Change in Dilijan National Park of Armenia between 1991 and 2019
Authors: Morin Nathalie , Masse Antoine , Sannier Christophe , Siklar Martin , Kiesslich Norman , Sayadyan Hovik , Faucqueur Loïc , Seewald Michaela
Published: July 2021

Dilijan National Park is one of the most important national parks of Armenia, established in 2002 to protect its rich biodiversity of flora and fauna and to prevent illegal logging. The aim of this study is to provide first, a mapping of forest degradation and deforestation, and second, of land cover/land use changes every 5 years over a 28-year monitoring cycle from 1991 to 2019, using Sentinel-2 and Landsat time series and Machine Learning methods. Very High Spatial Resolution imagery was used for calibration and validation purposes of forest density modelling and related changes. Correlation coefficient R2 between forest density map and reference values ranges from 0.70 for the earliest epoch to 0.90 for the latest one. Land cover/land use classification yield good results with most classes showing high users’ and producers’ accuracies above 80%. Although forest degradation and deforestation which initiated about 30 years ago was restrained thanks to protection measures, anthropogenic pressure remains a threat with the increase in settlements, tourism, or agriculture. This case study can be used as a decision-support tool for the Armenian Government for sustainable forest management and policies and serve as a model for a future nationwide forest monitoring system.
Combining IOTA and Attribute-Based Encryption for Access Control in the Internet of Things
Authors: Zhang Yuanyu , Nakanishi Ruka , Sasabe Masahiro , Kasahara Shoji
Published: July 2021

Unauthorized resource access represents a typical security threat in the Internet of Things (IoT), while distributed ledger technologies (e.g., blockchain and IOTA) hold great promise to address this threat. Although blockchain-based IoT access control schemes have been the most popular ones, they suffer from several significant limitations, such as high monetary cost and low throughput of processing access requests. To overcome these limitations, this paper proposes a novel IoT access control scheme by combining the fee-less IOTA technology and the Ciphertext-Policy Attribute-Based Encryption (CP-ABE) technology. To control the access to a resource, a token, which records access permissions to this resource, is encrypted by the CP-ABE technology and uploaded to the IOTA Tangle (i.e., the underlying database of IOTA). Any user can fetch the encrypted token from the Tangle, while only those who can decrypt this token are authorized to access the resource. In this way, the proposed scheme enables not only distributed, fee-less and scalable access control thanks to the IOTA but also fine-grained attribute-based access control thanks to the CP-ABE. We show the feasibility of our scheme by implementing a proof-of-concept prototype system using smart phones (Google Pixel 3XL) and a commercial IoT gateway (NEC EGW001). We also evaluate the performance of the proposed scheme in terms of access request processing throughput. The experimental results show that our scheme enables object owners to authorize access rights to a large number of subjects in a much (about 5 times) shorter time than the existing access control scheme called Decentralized Capability-based Access Control framework using IOTA (DCACI), significantly improving the access request processing throughput.
Locating Ships Using Time Reversal and Matrix Pencil Method by Their Underwater Acoustic Signals
Authors: Chaparro-Arce Daniel , Gutierrez Sergio , Gallego Andres , Pedraza Cesar , Vega Felix , Gutierrez Carlos
Published: July 2021

This paper presents a technique, based on the matrix pencil method (MPM), for the compression of underwater acoustic signals produced by boat engines. The compressed signal, represented by its complex resonance expansion, is intended to be sent over a low-bit-rate wireless communication channel. We demonstrate that the method can provide data compression greater than 60%, ensuring a correlation greater than 93% between the reconstructed and the original signal, at a sampling frequency of 2.2 kHz. Once the signal was reconstituted, a localization process was carried out with the time reversal method (TR) using information from four different sensors in a simulation environment. This process sought to achieve the identification of the position of the ship using only passive sensors, considering two different sensor arrangements.
A Study of Deep Learning-Based Face Recognition Models for Sibling Identification
Authors: Goel Rita , Mehmood Irfan , Ugail Hassan
Published: July 2021

Accurate identification of siblings through face recognition is a challenging task. This is predominantly because of the high degree of similarities among the faces of siblings. In this study, we investigate the use of state-of-the-art deep learning face recognition models to evaluate their capacity for discrimination between sibling faces using various similarity indices. The specific models examined for this purpose are FaceNet, VGGFace, VGG16, and VGG19. For each pair of images provided, the embeddings have been calculated using the chosen deep learning model. Five standard similarity measures, namely, cosine similarity, Euclidean distance, structured similarity, Manhattan distance, and Minkowski distance, are used to classify images looking for their identity on the threshold defined for each of the similarity measures. The accuracy, precision, and misclassification rate of each model are calculated using standard confusion matrices. Four different experimental datasets for full-frontal-face, eyes, nose, and forehead of sibling pairs are constructed using publicly available HQf subset of the SiblingDB database. The experimental results show that the accuracy of the chosen deep learning models to distinguish siblings based on the full-frontal-face and cropped face areas vary based on the face area compared. It is observed that VGGFace is best while comparing the full-frontal-face and eyes—the accuracy of classification being with more than 95% in this case. However, its accuracy degrades significantly when the noses are compared, while FaceNet provides the best result for classification based on the nose. Similarly, VGG16 and VGG19 are not the best models for classification using the eyes, but these models provide favorable results when foreheads are compared.
Adaptation Strategies of Migrant Workers from Ukraine during the COVID-19 Pandemic
Authors: Churski Paweł , Kroczak Hanna , Łuczak Marta , Shelest-Szumilas Olena , Woźniak Marcin
Published: July 2021

The COVID-19 pandemic has had far-reaching social and economic consequences. They are visible particularly in the functioning of local labour markets, affecting less privileged groups such as migrant workers, in a specific way. Here, our analysis aims to identify the strategies of adaptation of Ukrainian economic migrants to the changing situation in the local labour market in the Poznań agglomeration during the COVID-19 pandemic. The analysis relies on the results from quantitative research on changes in the demand for labour and adjustment of competence of immigrants to the Poznań agglomeration labour market throughout the pandemic and in the perspective of the nearest future, as well as on qualitative research conducted using the IDI (in-depth interviews) technique, carried out via the purposive sampling of 30 economically active Ukrainian migrant workers. The identified adaptation strategies are organised according to the assumptions of Pierre Bourdieu’s concept of capital(s). The capital of the researched group with respect to the labour market is treated as both the potential and resources the immigrants offer, produce, apply, and mutually convert in the implementation of their own adaptation strategies to the changing situation of the labour market. We extracted eight types of migrant adaptation strategies with respect to the labour market. These strategies differ in terms of objectives, resources, time perspectives, and other factors considered to be important from migrants’ perspectives. On the basis of interviews, we were able to assess the robustness of these strategies in view of economic shocks and identify the process of capital conversion and exchange.
Nuancing Holistic Simplicity in Sweden: A Statistical Exploration of Consumption, Age and Gender
Authors: Eimermann Marco , Lindgren Urban , Lundmark Linda
Published: July 2021

Studies of sustainable ways of life have hitherto made limited use of register data since, e.g., voluntary simplicity is usually identified through characteristics that cannot be found in data registers. Despite this, claims about these trends have been made in many countries, at times generalising the phenomena both in academia and media, based on anecdotal examples. This article draws on a quantifiable definition of holistic simplicity that includes certain fully measurable aspects, such as living in more affluent suburbs, moving to less affluent places and a significant reduction in individual work income. Other aspects are partially observable in register data, such as housing and car consumption. The advantage of this study is that it combines relevant theories around voluntary simplicity with register data that capture important characteristics of the entire national population (in this case, in Sweden) and thus, to some extent, also captures the magnitude of the phenomena. The article aims to statistically explore different demographic groups’ probability of becoming holistic simplifiers in Sweden, regarding their consumption, gender and age. It discusses opportunities and limitations for advancing our knowledge on voluntary simplicity in Sweden, with current findings suggesting more of the same consumption patterns and only initial paths to degrowth. This is discussed in the context of individuals’ agency in a state such as Sweden, which is changing from collectivist social democratic values to more neo-liberal conditions.
Development of an Integrated Structure for the Tri-Generation of Power, Liquid Carbon Dioxide, and Medium Pressure Steam Using a Molten Carbonate Fuel Cell, a Dual Pressure Linde-Hampson Liquefaction Plant, and a Heat Recovery Steam Generator
Authors: Ghorbani Bahram
Published: July 2021

Due to the increase in energy consumption and energy prices, the reduction in fossil fuel resources, and increasing concerns about global warming and environmental issues, it is necessary to develop more efficient energy conversion systems with low environmental impacts. Utilizing fuel cells in the combined process is a method of refrigeration and electricity simultaneous production with a high efficiency and low pollution. In this study, a combined process for the tri-generation of electricity, medium pressure steam, and liquid carbon dioxide by utilizing a molten carbonate fuel cell, a dual pressure Linde-Hampson liquefaction plant and a heat recovery steam generator is developed. This combined process produces 65.53 MW of electricity, 27.8 kg/s of medium pressure steam, and 142.9 kg/s of liquid carbon dioxide. One of the methods of long-term energy storage involves the use of a carbon dioxide liquefaction system. Some of the generated electricity is used in industrial and residential areas and the rest is used for storage as liquid carbon dioxide. Liquid carbon dioxide can be used for peak shavings in buildings. The waste heat from the Linde-Hampson liquefaction plant is used to produce the fuel cell inlet steam. Moreover, the exhaust heat of the fuel cell and gas turbine would be used to produce the medium pressure steam. The total efficiency of this combined process and the coefficient of performance of the refrigeration plant are 82.21% and 1.866, respectively. The exergy analysis of this combined process reveals that the exergy efficiency and the total exergy destruction are 73.18% and 102.7 MW, respectively. The highest rate of exergy destruction in the hybrid process equipment belongs to the fuel cell (37.72%), the HX6 heat exchanger (8.036%), and the HX7 heat exchanger (6.578%). The results of the sensitivity analysis show that an increase in the exit pressure of the V1 valve by 13.33% would result in an increase in the refrigeration energy by 2.151% and a reduction in the refrigeration cycle performance by 9.654%. Moreover, by increasing the inlet fuel to the fuel cell, the thermal efficiency of the whole combined process rises by 18.09%, and the whole exergy efficiency declines by 12.95%.
Regulatory Elements on the Circular Economy: Driving into the Agri-Food System
Authors: Zarbà Carla , Chinnici Gaetano , La Via Giovanni , Bracco Salvatore , Pecorino Biagio , D’Amico Mario
Published: July 2021

In the transition from linear production systems, unsustainable from the point of view of resources, to a model that finds strength in environmental, social and economic sustainability, the circular economy paradigm is the foundation that facilitates the planetary agro-ecological transition. The European Union has taken a number of steps (including the Circular Economy Package of Directives) shaping circularity as a wide-ranging driver measure involving many sectors. The paper intends to provide a regulatory framework on the current general situation regarding circularity in European Union, in order to extrapolate and give evidence to the aspects that intersect the agri-food sector. This is not only because they are poorly addressed in the literature, but also because there is a lack of regulatory instruments on the circular economy specifically addressing this area of interest. For this purpose, the analysis focuses on waste and residue/scrap management issues, recognized by law as by-products and end-of-waste status, as they are covered by circular economy legislation and as they can be applied to the agri-food sector. The latter allow the implementation of circularity strategies in the agri-food sector and, given the numerousness of production chains and the peculiarities of each of them, various regeneration and/or reuse processes of specific resources may be depicted. The intent is to provide useful knowledge on how to implement sustainable waste management, also proposing a concrete case on a by-product of olive oil processing, through which it is possible to highlight how the correct application of regulations favors the adoption of circular economic and management models in the firms involved, as well as informing the relevant economic operators on the possible profiles of legal liability that may arise from insufficient knowledge. Furthermore, this paper delves into the European Green Deal’s Strategy as it enriches the circular economy paradigm with new facets. NextGenerationEU and the National Recovery and Resilience Plan financially support this strategy in the aftermath of the socioeconomic crisis from COVID-19 in the EU Member States. This is in order to achieve the objective of achieving the agro-ecological transition.
Thermal Noise Decoupling of Micro-Newton Thrust Measured in a Torsion Balance
Authors: Cong Linxiao , Mu Jianchao , Liu Qian , Wang Hao , Wang Linlin , Li Yonggui , Qiao Congfeng
Published: July 2021

The space gravitational wave detection and drag free control requires the micro-thruster to have ultra-low thrust noise within 0.1 mHz–0.1 Hz, which brings a great challenge to calibration on the ground because it is impossible to shield any spurious couplings due to the asymmetry of torsion balance. Most thrusters dissipate heat during the test, making the rotation axis tilt and components undergo thermal drift, which is hysteretic and asymmetric for micro-Newton thrust measurement. With reference to LISA’s research and coming up with ideas inspired from proportional-integral-derivative (PID) control and multi-timescale (MTS), this paper proposes to expand the state space of temperature to be applied on the thrust prediction based on fine tree regression (FTR) and to subtract the thermal noise filtered by transfer function fitted with z-domain vector fitting (ZDVF). The results show that thrust variation of diurnal asymmetry in temperature is decoupled from 24 μN/Hz1/2 to 4.9 μN/Hz1/2 at 0.11 mHz. Additionally, 1 μN square wave modulation of electrostatic force is extracted from the ambiguous thermal drift background of positive temperature coefficient (PTC) heater. The PID-FTR validation is performed with experimental data in thermal noise decoupling, which can guide the design of thermal control and be extended to other physical quantities for noise decoupling.