bluuebunny/crossref_metadata_2025 huggingface dataset:
ISO 9000 SERIES STANDARDS IN THE SPHERE OF TOURISM AND HOSPITALITY OF UKRAINE IN THE CONCEPT OF TOTAL QUALITY MANAGEMENT TQM
Authors: Strygul Larysal , Aleksandrova Viktorija , Zhadan Tetiana
Published: December 2023

The article analyzes the current state of application and determination of the prospects for the implementation of ISO 9000 series standards in the field of tourism and hospitality of Ukraine in the concept of general quality management of TQM. It has been proven that the problem of post-war revival and development of processes of general management of the quality of services in the field of tourism and hotel and restaurant business of our state is quite urgent, based on its financial, economic and social importance for the reconstruction of the economy of our country. It was studied that as a result of the implementation of international standards, the activity of the enterprise (organization) becomes more understandable and transparent, a clear division of responsibility is established, the level of internal organization increases and the number of errors decreases. The difference between ISO 9001 and ISO 9000 is determined. The quality systems built on the ideology of the ISO 9000 series standards, which played their unique role in the development of technical and technological progress, are analyzed. It has been proven that the implementation of a quality management system developed on the basis of the ISO 9001 standard in an enterprise or organization contributes to the simplification of the system of service provision and the improvement of their quality, the establishment of established feedback with consumers, the improvement of the working climate, and the provision of stable work in conditions of staff turnover , making rational and effective decisions based on facts. The domestic level of standardization in the field of tourism and hospitality was studied in view of its correlation with international standards of general quality management. It has been proven that the standards of the ISO 9000 series, in particular the ISO 9001 standard, defines the most convenient and the most simple management model for today, and this model should be most fully used in the field of hospitality and tourism of Ukraine. It was concluded that effective quality systems that meet market requirements are today integrated into the concept of TQM — Total Quality Management. The main direction of the new version of the ISO 9000 series standards was their convergence with the ideology of TQM. In order for the domestic tourism business and the hospitality industry to have the opportunity to develop successfully, it is necessary to study all the rules and requirements of the ISO standard, as well as the methodology of their implementation at domestic enterprises in the field of hospitality.
FINANCIAL PLANNING OF ENTERPRISE ACTIVITIES BASED ON ORGANIZATIONAL DESIGN
Authors: Piatak Tetiana
Published: December 2023

In the course of the study, the essence of the relationship between organizational design and financial planning was analyzed. It has been established that, despite the variety of approaches to financial planning in practice, its functions are implemented in isolation in relation to organizational design, as a result of which the possibility of achieving an optimal financial result is reduced. It has been established that ensuring the relationship between financial planning and organizational design is possible with the introduction of an integrated approach. A number of tasks are given that should be solved at the stage of organizational and financial design in order to build an integral model of the enterprise. It is proposed to use an integral model that allows organizing management processes based on the interaction of production cycles and the organizational structure of the enterprise, which will optimize the relationship between organizational and financial planning at the enterprise. Financial planning will allow you to fully use the potential of the enterprise to achieve the desired financial results in the planning period. The presented model has a modular structure. The set of interacting modules makes it possible to take into account the peculiarities of the structural organization and production cycles of a particular enterprise. Separate structural subdivisions and stages of production cycles are represented by separate modules interacting with each other according to the selected algorithm. To build modules of structural elements and components of the production cycle, methods of mathematical and simulation modeling were used. The integral model makes it possible to study the interaction between production cycles and structural organization in two modes - multi-process and mono-process. The multi-process mode is used to study manufacturing enterprises with a large range of products. The single-process simulation mode is used to study highly specialized enterprises with one production cycle, as well as enterprises with a multi-process operation mode to determine the minimum time for each production cycle. The paper presents an algorithm for modeling the relationship between financial and organizational planning, which makes it possible to investigate the need for labor, material and financial resources of an enterprise. The model makes it possible to analyze various options for the interaction of a structural organization and production cycles, as well as to predict the optimal economic performance of an enterprise at the stage of organizational design and financial planning. It is concluded that due to the close relationship between financial and organizational planning identified with the help of an integral model, it becomes possible to predict the desired financial results using the potential capabilities of an enterprise for structural reorganization or the creation of a new organizational structure.
Adequacy of SNAP Benefits for Indiana Households, 2022
Authors: Babb Angela M. , Suttles Shellye A. , Daellenbach Isabelle , DuPilka Jenna H. , Knudsen Daniel C.
Published: December 2023

We investigated the adequacy of Supplemental Nutrition Assistance Program (SNAP) benefits for Indiana households. Methods included focus groups, interviews, and a statewide survey of 652 households. SNAP benefit-level increases over the course of the COVID-19 pandemic increased their adequacy overall yet were still inadequate for some households. As of June 2022, Indiana households reported their SNAP benefits lasting 13 days a month. The inadequacy of SNAP benefits reveals that some participating households still experience food insecurity, which has adverse public health implications. (Am J Public Health. 2023;113(S3):S224–S226. https://doi.org/10.2105/AJPH.2023.307408 )
Women, Infants, and Children (WIC) Enrollment: Learning From Key Informants to Enhance Utilization
Authors: Ganacias Karen , Rethy Janine A.
Published: December 2023

Enrollment in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is suboptimal, particularly for eligible children aged 1 to 4 years. We used converged data from key informants from October 2021 to January 2023 to understand the barriers to and opportunities for WIC utilization and the role of the health care provider in links to WIC. Families and WIC staff identified gaps in provider knowledge and an expressed need for improved collaboration between health providers and WIC. (Am J Public Health. 2023;113(S3):S220–S223. https://doi.org/10.2105/AJPH.2023.307443 )
Mechanism of the first and second peaks in epinephrine pharmacokinetics over time
Authors: Lockey Richard F. , Ellis Anne K. , Lowenthal Richard , Tanimoto Sarina
Published: December 2023

Background: There is a documented double peak phenomenon following the intramuscular injection of epinephrine, however these peaks are typically representative of mean epinephrine concentrations and not individual subjects.
Objective: An examination of epinephrine pharmacokinetics was conducted to explore the nature of the double peak phenomenon and to determine if the double peaks observed in mean concentration profiles were also observed in individual subjects.
Methods: A GCP compliant study was conducted in 36 adult volunteers with a history of type I allergies. Blood samples were collected before and at multiple timepoints after subjects self- administered two FDA-approved epinephrine auto-injectors (EpiPen 0.3 mg and Symjepi 0.3 mg). Pharmacokinetic parameters (Cmax and tmax) and concentration-time curves were determined based on individual subjects. Subjects were categorized by their tmax (≤4 min, >4 min - ≤10 min, >10 min - ≤20 min, >20 min - ≤30 min, >30 min - ≤45 min, and >45 min, presented as ≤4 min, ≤10 min, ≤20 min, ≤30 min, ≤45 min, and >45 min, respectively).
Results: The majority of individual subjects did not have double peaks. Double peaks in mean concentration-time profiles were observed when tmax was ≤4 min following EpiPen and Symjepi, tmax ≤30 min following EpiPen, and tmax ≤45 min following EpiPen. The individual epinephrine concentration curves for subjects with a tmax ≤4 min following EpiPen and Symjepi and tmax ≤45 min following EpiPen demonstrate that the majority of individual subjects do not have double peaks.
Conclusion: These data suggest that the double peaks observed in mean epinephrine concentrations are likely driven by subsets of subjects with either early or late tmax values and may not necessarily be a pharmacokinetic characteristic of epinephrine.
Is proanthocyanidin associated to vitamin E or palm oil able to protect enamel against initial erosion in vitro?
Authors: Martins Daiana da Silva , Boteon Ana Paula , Silva Thayná Theodoro da , Sabino Julia Fiorese , Ionta Franciny Querobim , de Oliveira Angélica Aparecida , Honório Heitor Marques , Buzalaf Marília Afonso Rabelo , Carvalho Thiago Saads , Rios Daniela
Published: December 2023

Objectives
This in vitro study evaluated the effect of Proanthocyanidin, Palm Oil and Vitamin E against initial erosion.
Materials and Methods
Bovine enamel blocks (n = 140) were divided into 14 groups: PC_SnCl2/NaF/Am-F-containing solution (positive control); NC_deionized water (negative control); PO_palm oil; P6.5_6.5% proanthocyanidin; P2_2% proanthocyanidin; VE_Vitamin E; POP6.5_palm oil + 6.5% proanthocyanidin; P6.5PO_6.5% proanthocyanidin + palm oil; POP2_palm oil + 2% proanthocyanidin; P2PO_2% proanthocyanidin + palm oil; VEP6.5_Vitamin E + 6.5% proanthocyanidin; P6.5VE_6.5% proanthocyanidin + Vitamin E; VEP2_Vitamin E + 2% proanthocyanidin; P2VE_2% proanthocyanidin + Vitamin E. The acquired enamel pellicle (AEP) was previously formed in situ for 30 min. The specimens were treated in vitro with the solutions (500 µl, 30s). Then, the blocks were maintained for an additional hour in oral cavity to develop the modified AEP. The blocks were immersed in 0.5% citric acid (pH 2.5) during 30s. The response variable was the percentage of surface hardness loss. Data were analyzed by one-way ANOVA and Fisher's Test (p < 0.05).
Results
P6.5VE was the only group to promote protection similar to PC. PO, P2, POP6.5, P2PO, P6.5VE and P2VE exhibited %SHL similar to both PC and NC groups. (p < 0.05). P6.5, VE, P6.5PO, POP2, VEP6.5 and VEP2 were different to PC and similar to NC.
Conclusion
It is concluded that proanthocyanidin associated to vitamin E was able to protect enamel against in vitro initial erosive challenge.
Clinical Relevance:
This study suggests the potential for a cost-effective anti-erosion product. Further investigations across diverse experimental models are warranted to validate these promising outcomes.
The cardiovascular benefits of glucagon-like peptide-1 receptor agonists as novel diabetes drugs are mediated via the suppression of miR-203a-3p and miR-429 expression
Authors: Liu Yanfen , Nie Dongying , Lou Xueyong
Published: December 2023

Purpose
Coronary artery disease (CAD) is associated with a high fatality rate and a heavy global health care burden. Glucagon-like peptide-1 (GLP-1) exerts positive cardiovascular effects, although the molecular mechanisms are unclear. Therefore, this study aimed to verify whether the cardioprotective effects of GLP-1 are mediated through the regulation of micro-RNA (miRNA) expression.
Materials and Methods
Follow-up assessments were conducted for 116 patients with type 2 diabetes alone (controls) and 123 patients with both type 2 diabetes and CAD. After matching, each group comprised 63 patients, and age, body mass index, and serum levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and haemoglobin A1C were compared. Subsequently, the expression profiles of four circulating miRNAs (miR-203a-3p, miR-429, miR-205-5p, and miR-203b-5p) were assessed via qRT-PCR in the 63 patients with diabetes and CAD between six months (baseline) and twelve months after the initiation of GLP-1 therapy.
Results
As expected, the metabolic factors were significantly improved after 6 months of treatment with GLP-1 compared with pre-treatment values, and the expression levels of two of the miRNAs (miR-203a-3p and miR-429) decreased from baseline levels in those with diabetes and CAD.
Conclusions
The results suggest that the cardiovascular benefits induced by GLP-1 are mediated via suppressed expression of two miRNAs: miR-203a-3p and miR-429.
Determination of charring conditions of archaeological grape seeds, towards machine-learning based classification
Authors: Reuveni Yuval , Landa Vlad , Shapira Yekaterina , Behar Adi , Ben-Arie Reut , Weiss Ehud , Drori Elyashiv
Published: December 2023

This study investigates the chemical and morphological changes in grape pips resulting from various charring conditions. Employing Fourier Transform Infrared Spectroscopy (FTIR) for chemical analysis and high-resolution scanning combined with morphometric measurements for morphological analysis, we aimed to understand the effects of charring on grape pips. Our hypothesis regarding the potential of chemical composition for distinguishing charring temperatures was partially supported, as FTIR analysis revealed distinctive changes in chemical bonds at different temperatures. However, FTIR spectra of archaeological seeds showed limited utility for identification due to postdeposition alterations masking the original chemical fingerprint. In addition, morphometric analysis demonstrated significant alterations in seed shape above 250℃, corroborating FTIR findings. The length:width ratio and the occurrence of cracks notably changed, providing a basis for assessing charring conditions. Applying a machine learning classification method, we determined that accurate classification of grape varieties by the morphometric analysis method is feasible for seeds charred at up to 250℃ and 8 hours. Integrating the morphometric changes and temperature ranges suitable for classification, we developed a sorting model for archaeological seeds. By projecting length:width ratios onto a curve calculated from controlled conditions, we estimated charring temperatures. Approximately 50% of archaeological seeds deviated from the model, indicating drastic charring conditions. This sorting model facilitates a stringent selection of seeds fit for classification, enhancing the accuracy of our machine learning-based methodology. In conclusion, combining machine learning with morphometric sorting enables the identification of charred grape seeds suitable for identification by the morphometric method. This comprehensive approach provides a valuable tool for future research for the identification of charred grape seeds found in archaeological contexts, enhancing our understanding of ancient viticulture practices and grape cultivation.
Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells
Authors: Dietrich-Zagonel Franciele , Alim MD Abdul , Beckman Leo Bon , Eliasson Pernilla
Published: December 2023

Inflammation, corticosteroids, and loading all affect tendon healing, with an interaction between them. However, underlying mechanisms behind the effect of corticosteroids and the interaction with loading remain unclear. The aim of this study was to investigate the role of dexamethasone during tendon healing, including specific effects on tendon cells.
Rats (n = 36) were randomized to strong or moderate loading, the Achilles tendon was transected, and animals were treated with dexamethasone or saline. Gene and protein analyses of the healing tendon were performed for extracellular matrix-, inflammation-, and tendon cell markers. We further tested specific effects of dexamethasone on tendon cells in vitro.
Dexamethasone increased mRNA levels of S100A4 and decreased levels of ACTA2/α-SMA, irrespective of load level. Strong loading + dexamethasone reduced mRNA levels of FN1 and TenC (p < 0.05), while resolution-related genes were unaltered (p > 0.05). In contrast, moderate loading + dexamethasone increased mRNA levels of resolution-related genes ANXA1, MRC1, PDPN, and PTGES (p < 0.03). Altered protein levels were confirmed in moderately loaded tendons. Dexamethasone treatment in vitro prevented tendon construct formation, increased mRNA levels of S100A4 and decreased levels of SCX and collagens.
Dexamethasone during tendon healing appear to act through immunomodulation by promoting resolution, but also through a direct effect on tendon cells.
On the Generalized Jordan-Derivation Over -Paranormal Operators
Authors: Hamada Nuha
Published: December 2023

Let B(H) be the set of all bounded linear operations on the separable infinite dimensional Hilbert spaces. The mapping $J_{A, B}(T)=TA-BT^*$ is called generalized Jordan*-derivations. Researchers have thoroughly investigated the characteristics of $J_{A, B}(T)$ within specific classes of operators A and B. The characterization of the properties of A and B relies significantly on the range of $J_{A, B}(T)$. In this paper, we investigate the generalized Jordan *-derivations $J_{A, B}(T)=TA-BT^*$ over *- paranormal operators A and B. The author shows among other results that if the identity operator belongs to the range of generalized Jordan *-derivations $J_{A, B}$ over *- paranormal operators A and B where $\partial\sigma(A)=\partial\sigma(B)$, then A and B are invertible skew-Hermitian operators.
An Exploratory Study of the Experiences of African International Students in U.S. Higher Education
Authors: Amoateng Ernest Yaw
Published: December 2023

Given the increasing number of international students attending US higher education institutions, it is imperative to study the experiences of African students’ transition period, as they acculturate into the American culture and educational system. The uniqueness of African international students may be different from the experiences of international students from other regions. As a result of the account of African students, university counseling centers, campus services, and those who interact with and support these students, the initial and ongoing stress of living in a foreign country and adapting to a new way of life can be eased. Six African international students participated in individual semi-structured qualitative interviews conducted at a Midwest research university. To better understand cross-cultural adjustment, a basic interpretive qualitative research (BIQR) design was utilized. The interview texts were analyzed based on the basic interpretive qualitative approach, which has been described as containing elements of induction, theoretical, and constant comparison. Findings indicated specific experiences regarding African international students’ adjustment to the US environment, including strategies perceived as helpful in specific situations. Based on the analysis of participant interviews, the major themes that arose from the interviews included: academic prowess; social integration; and cultural integration. Implications for research and practice have been discussed. It is recommended that future researchers examine the unique subpopulations of international students’ cross-cultural adjustments and experiences.
Sulphotransferase (SOT) genes in wheat providing tolerance against drought and heat
Authors: chaudhary Jyoti , Gangwar Himanshi , Jaiswal Vandana , Gupta Pushpendra Kumar
Published: December 2023

Sulphotransferase (SOT) genes that are involved in sulphonation during sulphate metabolism, represent a conserved family of genes, which provide tolerance against abiotic stresses like heat and drought in plants. In plants, sulphate metabolism is a component of primary metabolism, where SOTs catalyze sulphonation. In the present study in wheat, 107 TaSOT genes were identified; 78 of these genes were identified through genome-wide search and the remaining 29 identified through SOT domain (PF00685) (sulfotransferase family protein). All 107 genes were mapped onto individual chromosomes. The length of these ranged from 969bp to 7636bp; 73 (68%) of these 107 genes are intronless. The gene sequences were associated with 48 different cis regulatory elements. The genes also carry some tandem/segmental duplications, SSRs (simple sequence repeats), target sites for miRNAs and sequences for some lncRNAs. The promoters of some genes also carried transcription factor binding sites (TFBS). The SOT proteins carried two highly conserved 5’-phosphosulphate-binding (5’ PSB) regions and a 3’-phosphate-binding (3’ PB) motif that are essential for SOT activities. Homology modeling of TaSOT proteins and docking analysis of their ligand-binding sites revealed the presence of important amino acids in their active sites. An expression assay of TaSOT genes via wheat RNA-seq data suggested engagement of these genes in growth, development and responses to various hormones and biotic/abiotic stresses. The results of the present study should help in further functional characterization of SOT genes in wheat and other related crops.
An efficient monitoring of HELLP syndrome pre-eclampsia in wireless sensors networks
Authors: ullah Muneeb , Young Xiadong , khan Muhammad Faizan , Junaid Junaid , Dai Shihan
Published: December 2023

This paper explores the application of wireless sensing using 5G technology in the 4.8 GHz C-band, a significant step forward in healthcare innovation. It focuses on the application of wireless sensing to monitor HELLP syndrome in cases of pre-eclampsia, showcasing how Wireless Sensor Networks (WSNs), enhanced by 5G's high-speed capabilities, substantially improve real-time data transmission and healthcare decision-making. The integration of WSNs with 5G technology enables non-invasive, continuous patient monitoring, providing advanced solutions for remote health surveillance and efficient data management in critical healthcare situations. Specifically, the study highlights the use of a wireless transceiver in indoor environments to monitor various body movements, including those indicative of HELLP syndrome symptoms. These movements generate unique wireless data, thus enriching the understanding of wireless channel information. The research explores deep learning models such as ANN, CNN, and especially VGGNet, which achieved a notable 99.26% accuracy in classifying patient activities. Additionally, the paper discusses model optimization, emphasizing the need for adjustments in parameters such as batch sizes and hidden units to enhance performance. The study's outcomes, evaluated using metrics such as accuracy, recall, precision, specificity, and F-measure, demonstrate the superior performance of VGGNet compared to other classifiers. These findings underscore the potential of integrating advanced technologies like WSNs and 5G in healthcare, highlighting their role in creating more effective, reliable, and patient-centric healthcare systems
Auswirkungen fahrradfreundlicher Infrastruktur auf Gewerbetreibende : eine qualitative Untersuchung zum Einfluss einer Fahrradstraße auf Gewerbetreibende am Beispiel des Frankfurter Grüneburgwegs
Authors: Ali Khogali Sophie , Behnel Aileen , Kalbhenn Johann , Kunz Patrick , Wilhelmi Lara Sophie
Published: December 2023

Im Rahmen des Maßnahmenpakets zur Förderung fahrradfreundlicher Infrastruktur wurde der Frankfurter Grüneburgweg zur Fahrradstraße umgebaut. Mit Fokus auf Gewerbetreibende wurde zwischen März und April 2023 eine Studie zu den Auswirkungen der Fahrradstraße auf dem Grüneburgweg im Frankfurter Westend durchgeführt. Insgesamt wurden 12 Interviews mit ortsansässigen Einzelhandel- und Gastronomiebetreiber:innen geführt. Im Zentrum standen dabei die Auswirkungen der Fahrradstraße auf die geschäftlichen Aktivitäten sowie Einflussfaktoren der Akzeptanz solcher Maßnahmen. Es konnte herausgearbeitet werden, dass die Fahrradstraße aus Sicht der ansässigen Gewerbetreibenden einen negativen Einfluss auf die Erreichbarkeit des Grüneburgwegs hat. Dies geht laut den befragten Gewerbetreibenden mit Umsatzverlusten, einem Rückgang an Kund:innen und Problemen mit der Warenlieferung einher. Ferner wird von einigen Gewerbetreibenden kritisiert, nicht rechtzeitig seitens der Stadt über den Umbau informiert worden zu sein und kein Mitspracherecht bei der Gestaltung der Fahrradstraße zu haben. Die von vielen Gewerbetreibenden wahrgenommenen Auswirkungen auf ihre geschäftlichen Aktivitäten, ihre Einbeziehung in den Planungs- und Umbauprozess sowie ihr eigenes Mobilitätsverhalten sind zentrale Einflussfaktoren für die Akzeptanz der Fahrradstraße. Die Ergebnisse zeigen, dass viele Gewerbetreibende zwar eine positive Einstellung zur Fahrradstraße haben, jedoch den Grüneburgweg nicht als einen geeigneten Standort für eine Fahrradstraße halten. Aus den Ergebnissen lässt sich schließen, dass für künftige Umgestaltungen besonders auf eine gute Kommunikation der Stadt mit den Gewerbetreibenden geachtet werden muss.
Una perspectiva computacional y de análisis estadístico de textos para el Análisis de Sentimiento de la conversación en redes sociodigitales alrededor de debates electorales
Authors: Espitia Diego , Atilano Julián , Zumaya Martín
Published: December 2023

Este trabajo analiza el impacto de las redes sociales en la imagen mediática y la percepción pública de los candidatos en los debates electorales del Estado de México de 2023, utilizando herramientas computacionales y estadísticas para examinar el sentimiento de 40,866 tweets. Se identificaron mayormente menciones negativas hacia Delfina Gómez de la coalición “Juntos hacemos historia”. Sin embargo, a pesar de esto, su campaña fue efectiva en transmitir su imagen mediática, destacándose la palabra “maestra” en las publicaciones sobre ella. Por otro lado, la imagen de Alejandra del Moral de la alianza “Va por el Estado de México” no tuvo el mismo impacto mediático en los tweets analizados. Este estudio muestra la relevancia de las redes sociales en las estrategias de campaña modernas, evidenciando cómo las discusiones digitales influencian la construcción de la imagen de los candidatos. La combinación de análisis cuantitativo y cualitativo permite entender no solo la cantidad de menciones, sino también el contexto y la evolución de la percepción pública. Este enfoque proporciona una metodología alternativa para analizar eventos políticos y sociales en la era digital.
Estudio zooarqueológico y tafonómico del Yacimiento Calcolítico Las Zanjillas (Torrejón de Velasco, Madrid)
Authors: Estaca-Gomez Verónica , López German , Morín Jorge , Yravedra José
Published: December 2023

Las Zanjillas (Torrejón de Velasco, Madrid) es un yacimiento Calcolítico precampaniforme ubicado en el valle medio del Tajo, caracterizado por más de 500 estructuras que incluyen silos y cubetas. Este estudio se centra en el análisis zooarqueológico y tafonómico de muestras óseas encontradas en este sitio. A diferencia de otras acumulaciones faunísticas en sitios precampaniformes de la región, aquí no se observan depósitos de individuos completos de animales; en cambio, se identifican acumulaciones de fauna de contextos domésticos, mayormente compuestas por restos de vacas y caprinos. Los análisis tafonómicos revelan la presencia de marcas de cortes en todos los taxones, indicando un aprovechamiento cárnico de los animales. No obstante, los patrones de mortalidad identificados en las distintas especies domésticas señalan un predominio de individuos adultos, lo que podría sugerir usos alternativos de las cabañas ganaderas más allá de su función exclusivamente cárnica. Este aspecto, sumado a las cronologías proporcionadas por el sitio, plantea un interesante punto de discusión que abordaremos en este trabajo.
HÁ CINQUENTA ANOS, EM 1973...
Authors: Barros Diana Luz Pessoa de
Published: December 2023

O texto, uma mistura de depoimento e de artigo, procura mostrar o papel do curso ministrado por Greimas no Brasil, em julho de 1973, não apenas como um elemento facilitador da recepção da semiótica discursiva, mas, sobretudo, como o gesto fundador de uma escola de semiótica no Brasil. Foram observadas três principais decorrências do curso de 1973: a oportunidade de participação em um “seminário de Greimas”; a fundação do Centro de Estudos Semióticos A. J. Greimas; e a criação da revista Significação – Revista Brasileira de Semiótica, órgão oficial de publicação do Centro.
Políticas internacionais de educação
Authors: Marinho Tarcyla Coelho de Souza , Araujo Liane Castro de
Published: December 2023

O artigo apresenta reflexões críticas sobre a formação continuada de professoras alfabetizadoras em cotejo com as políticas internacionais de educação e alfabetização. A pesquisa teve como objetivo conhecer como os efeitos das orientações dos organismos internacionais para a educação e alfabetização se manifestam no discurso das participantes da formação continuada do Pacto Nacional pela Alfabetização na Idade Certa (PNAIC) realizada no município de Santa Cruz Cabrália, BA. A metodologia adotada é a abordagem qualitativa, cujo método é tomado na perspectiva dialética, em aproximação com a corrente de pensamento marxista e os pressupostos da Teoria Crítica. O procedimento utilizado foi a entrevista semiestruturada com participantes da formação continuada do PNAIC. Os resultados indicam que, por um lado, se a formação continuada sofreu os efeitos da política neoliberal que desenhava o PNAIC, por outro, a ação formativa se associou ao que demandam as escolas no esforço de transformação da realidade objetiva.
Wastewater Monitoring Program in Abu Dhabi – A Boon to Early Warning & Public Health Issue Prevention
Authors: Salem Samara Bin , Jagadeesan Premanandh , Elamin Wael
Published: December 2023

The recent establishment of the wastewater monitoring regime by the Abu Dhabi (United Arab Emirates) Government as a tool to monitor the status of community well-being by studying the excretions from the sewage to steer global benchmarks of excellence in public health has been presented. The relevance of microbes and other chemical compounds in sewage and their significance for public health monitoring within the sampled community has been discussed. The key advantage of wastewater monitoring in establishing baseline data and its benefit in assessing the trend in infectious diseases, antimicrobial resistance, and illicit drugs has been presented. Undoubtedly, it is a classic tool available today for early warning signals and trend analysis for policymakers to monitor and avoid the catastrophic impact of deadly pathogens and chemical contaminants upon addressing the challenges.
Patrícia Galvão: A Primeira Quadrinista Brasileira
Authors: Avelino Stella
Published: December 2023

Embora muitos nomes masculinos tenham sido reconhecidos na história dos quadrinhos brasileiros, poucas figuras femininas são lembradas. Nesse sentido, este artigo tem por objetivo a análise de dois trabalhos de Patrícia Galvão: o álbum “Nascimento, Vida, Paixão e Morte” e a série de oito tiras publicadas no jornal O Homem do Povo, intitulada “Malakabeça, Fanika e Kabelluda”. Mais conhecida como Pagu, Patrícia Galvão é hoje reconhecida como a primeira mulher a publicar quadrinhos no Brasil. “Nascimento, Vida, Paixão e Morte” foi produzido quando a autora tinha apenas 19 anos e configura-se como uma narrativa gráfica autobiográfica, a qual pode ser considerada como o primeiro quadrinho brasileiro escrito e desenhado por uma mulher. Além disso, Pagu inaugurou a produção de tiras de autoria feminina e com temática feminista no Brasil, ao trazer duas representações femininas diferentes em “Malakabeça, Fanika e Kabelluda”: a esposa tradicionalista e a jovem contestadora e fora dos padrões convencionais. A despeito de sua inovação e importância no cenário cultural brasileiro, Patrícia Galvão foi — e, por vezes, ainda é — frequentemente reconhecida apenas como “musa modernista” ou ainda pelas suas relações pessoais com escritores renomados. Assim, reexaminar a produção de Patrícia Galvão é necessário, uma vez que, enquanto mulher e independente de suas ligações, ela produziu obras de importância significativa na comunicação e na disseminação de mensagens políticas feministas e contra a discriminação e violência de gênero. Portanto, torna-se fundamental reconhecer e repensar o papel de Patrícia Galvão/Pagu na história dos quadrinhos brasileiros.
Multiplicidades, Narrativas de Vida e Memória Coletiva da Docência na História em Quadrinhos Fessora!
Authors: Bretas Lage Nara , Coan Samanta
Published: December 2023

O artigo apresenta o quadrinho Fessora!, desenhado e escrito pela brasileira Aline Lemos, publicado de modo independente e por financiamento coletivo em 2021. A história narrada tem como enfoque a experiência pessoal da autora quando foi docente de história no ensino público por um semestre. A autora nos apresenta um conjunto de 15 histórias que abordam suas memórias pessoais com colegas de trabalho, corpo discente e pais. Neste texto, foram selecionadas seis bandas desenhadas, a fim de compreender, a partir das memórias e dos fragmentos de vida narrados, as tensões e confluências entre as vivências de trabalho acionadas pela artista. Retratam sua experiência pessoal como professora, revelando o cotidiano de professores da educação pública no Brasil. Para esta análise, usamos a ótica da narrativa de vida da linguista argentina Leonor Arfuch (2002/2003, 2013), quanto à relação entre narrativas de vida contemporâneas e o espaço biográfico; e a noção de memória coletiva (Halbwachs, 1950/1999; Bosi, 2009) para compreender a multiplicidade de experiências a partir da memória individual. Conclui-se que Aline Lemos apresenta uma obra que evidencia os desafios da educação sobre a valorização do docente e as desigualdades sociais em sala de aula.
Preaching the Truth under Communism
Authors: Koppándi Botond
Published: December 2023

This study aims to explore if the preaching of the Truth of the Unitarian Church from Transylvania, Romania, under the oppressive times of the Communist regime was ever possible? Relying on personal and historical backgrounds, the article will explore how it was even possible ministering to people when the state was suppressing free speech and was threatening the mere existence of the churches and its clergy. Personal memories from the 1980’s will try to give a clearer picture about how allegorical language and parallels understood by those under oppression were giving hope to those in suffering. The short review of the long process of re-launching of a theological journal will show the difficulties of speaking the truth. And the presentation of the tragic fate of a theological professor who was convicted for his sermons which were considered to be dangerous, will definitely lead us to realize that preaching the truth of the Gospel was not always easy for those who had to live under the heavy dictatorship of communist times.
Analysis of the structure of scheduled airline services in Central European countries. Part one
Authors: Serafin Marek
Published: December 2023

The post-pandemic period is particularly important for the European airline market. We can observe new trends of changes that will shape it for many years to come. We can already clearly see that the Central European region has its own specificity, distinguishing it from Western Europe. In the case of our country, analysing the situation and forecasting the future is particularly important, as decisions are currently being taken regarding huge infrastructure investments. The structure of the number of seats offered by scheduled airlines and the changes in it are very good indicators of the strategies of air carriers, the most important players in the market game. Key words: network carriers, low-cost airlines, trends of change
Analysis of the structure of scheduled airline services in Central European countries. Part two
Authors: Serafin Marek
Published: December 2023

The post-pandemic period is particularly important for the European airline market. We can observe new trends of changes that will shape it for many years to come. We can already clearly see that the Central European region has its own specificity, distinguishing it from Western Europe. In the case of our country, analysing the situation and forecasting the future is particularly important, as decisions are currently being taken regarding huge infrastructure investments. The structure of the number of seats offered by scheduled airlines and the changes in it are very good indicators of the strategies of air carriers, the most important players in the market game. Key words: network carriers, low-cost airlines, trends of change
Identity in the cultural landscapes of the Mazovian Voivodeship and beyond
Authors: Baranowska Ewa , Pankowska Marta , Dobrosielska Agnieszka
Published: December 2023

The article presents areas distinguished by local tradition and the preservation of rituals and customs in the Mazovian Voivodeship (Mazovia region) and points out the role of society in shaping and preserving intangible cultural heritage. Additionally, an assessment of the state of preservation or development of synthetic characteristics of the municipal landscape, such as tradition, identity, and localness, was carried out following the methodology outlined in the Ordinance of the Council of Ministers dated January 11, 2019, regarding the preparation of landscape audits. The analyses were conducted based on the results of a survey carried out by the research team of the Department of Spatial Planning and Environmental Sciences at the Faculty of Geodesy and Cartography at the Warsaw University of Technology, commissioned by the Mazovian Office of Regional Planning in Warsaw, within the territory of the Mazovian Voivodeship. The research survey included 9 questions related to cultural heritage, of which, for the purposes of this article, 4 questions directly related to material and intangible heritage were analyzed among the 6,160 surveys conducted. The scope of analysis of material heritage pertained to the presence of traditional architecture, and the intangible heritage included ethnographic regions, preserved traditions, rituals, and customs, as well as the engagement of the society in the “cultural life” of their small homelands. The analysis of the questionnaires allowed for the confirmation of the presence of previously identified and indicated elements in the documents of the voivodeship self-government, as well as the identification of new areas of tangible and intangible cultural heritage in the Mazovian voivodeship. These findings were compared with the literature on the subject and the records in the documents of the voivodeship self-government. The results of the study indicated the significant role of local self-government units, cultural institutions, as well as associations and organizations that bring together local communities in shaping and preserving the intangible cultural heritage. The degree of engagement of the respondents in cultivating traditions, rituals, and customs was found to be independent of their location in ethnographic regions, according to the survey responses. The responses of the survey participants also pointed to the “return to roots” trend resulting from the growing interest in folk culture, supported by popularizing and promoting folk traditions. In the process of intergenerational transfer of values and the richness of cultural heritage, education of the society, especially the younger generation, plays a crucial role. Key words: cultural landscape, tradition, architecture, ethnographic regions, cultural heritage
Percepción de competencias investigativas, innovación y emprendimiento en estudiantes universitarios
Authors: Ángela-María Cárdenas-Ortega  , Luz-Élida Vera-Hernández  , Harold-Armando Juajibioy-Otero  , Eunice Yarce-Pinzón
Published: December 2023

Analizar la percepción del desarrollo de competencias investigativas, de innovación y emprendimiento de estudiantes de una universidad privada de la ciudad de Pasto, Colombia, para generar programas y estrategias en formación investigativa en la comunidad académica.
Tecnologías de Visualización en el Aprendizaje del Diseño y la Arquitectura
Authors: López Altamirano Otniel
Published: December 2023

La Realidad Aumentada es una de las tecnologías inmersivas con posibilidades de contribuir a la transformación del aula en un ecosistema de medios, al servicio de la educación de calidad para alumnos en formación de diseño y arquitectura, ya que esta les permite la visualización de proyectos de manera más intuitiva al enriquecer o alterar la información del producto en su entorno físico; consolidando así, nuevos aprendizajes híbridos e interactivos entre jóvenes con habilidades digitales.
Challenges of Establishing Trade Unions in Chinese Private Enterprises
Authors: Ma Xiaoyi
Published: December 2023

Trade unions serve as a bridge and bond between the Communist Party of China and the working masses, and the construction of grassroots trade unions is crucial for the welfare of workers and social stability. In a survey conducted in Beijing, it was found that an increase in the number of private enterprises does not necessarily lead to a corresponding increase in the number of trade unions within these enterprises. Similarly, an increase in the total number of employees in private enterprises does not guarantee an increase in the total membership of trade unions in these enterprises. The difficulty in establishing trade union organizations is influenced by multiple factors: enterprises need to control costs under the “uncertainty” of risks, employees lack understanding of trade unions, and the trade unions themselves lack professionalism and effective measures to participate in social governance. In the future, the issue of the difficulty in establishing trade unions should be addressed by developing social work in trade unions, effectively utilizing media platforms of trade unions, and further improving laws and regulations.
IN SILICO STUDY OF THE SYNERGISTIC INTERACTION OF 5-FLUOROURACIL AND CURCUMIN ANALOGUES AS INHIBITORS OF B-CELL LYMPHOMA 2 PROTEIN
Authors: AMAN LA ODE , ARFAN  , ASNAWI AIYI
Published: December 2023

Objective: The research objective is to explore the potential for synergistic inhibition of two curcumin analogs combined with 5-fluorouracil (5-FU) against the B-cell lymphoma 2 (BCL-2) protein.

Methods: We investigated the synergistic inhibition of two curcumin analogs, namely, (1E,4E)-1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one (AC01) and (1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one (AC02), each combined with 5-FU by calculating their binding free energies and binding stability. An in silico investigation of the synergistic interaction of ligand pairs was conducted using the multiple ligand simultaneous docking (MLSD) technique with the AutoDock Vina package. The stability of interactions and binding free energies of each BCL-2 and curcumin analogs were examined by applying molecular dynamics techniques with the Gromacs package and MMPBSA method.

Results: All ligand pairs had displayed strong binding affinity, as evidenced by highly negative free energy values, indicating a robust association with BCL-2. Molecular dynamics simulations were conducted over 100 ns, confirming good stability with controlled RMSD changes, suggesting that the ligand pairs had remained securely bound to the BCL-2 binding site. Additionally, RMSF analysis and energy decomposition had revealed that ligand interactions did not influence protein residue fluctuations during the simulation, and the protein-ligand complexes had maintained stability throughout the simulation. Furthermore, binding free energy calculations using the MMPBSA method had consistently shown negative values, signifying stable interactions with BCL-2 for all ligand pairs.

Conclusion: In conclusion, our study revealed that AC01 and AC02, when combined with 5-FU, had the ability to intercalate into the P2 and P4 sites of BCL-2. This suggested that AC01 and AC02 held promise for further study as candidates for anticancer drugs, individually or in combination with 5-FU.
METHOTREXATE-INDUCED ORAL ERYTHEMA MULTIFORME
Authors: SANTOSO ASTRID WIDHOWATY , SHAFURIA AMIRA , DEWI TENNY SETIANI
Published: December 2023

Objective: To discuss the management of oral erythema multiforme (EM) due to methotrexate (MTX) in gestational trophoblastic tumor patients.

Methods: A 28-year-old woman was referred to the Oral Medicine Clinic with complaints of pain throughout the oral cavity accompanied by blackish encrustation on the upper and lower lip for 5 d. She previously underwent the first cycle of chemotherapy using MTX for the treatment of a gestational trophoblastic tumor. Extraoral, multiple diffuse blackish patches on the face and haemorrhagic crusts on the lips with painful erosions. Intraoral, multiple erosive and ulcerative lesions on the labial and buccal mucosa.

Results: Management involved topical 0.025% hyaluronic acid mouthwash for erosion and ulceration, compressed 0.9% NaCl for crusted lesions on the lips, and petroleum jelly for the non-crusted lesions on the lips. Complete healing of oral and lip lesions was achieved within 10 d.

Conclusion: Pharmacological management should be tailored to each patient with careful consideration of treatment risk or benefit. In our case, the use of non-steroidal anti-inflammatory topical agents was considered successful in treating oral EM.
ISOLATION OF CELLULOSE FROM SIWALAN FIBER (BORASSUS FLABELLIFER L.) USING RESPONSE SURFACE METHODOLOGY
Authors: AZAMI YUSUF IKROM NUR , MUSFIROH IDA , MUCHTARIDI  , PRATIW RIMADANI , PUTRA OKTA NAMA
Published: December 2023

Objective: This study investigated the isolation of α-cellulose powder from siwalan fibers (Borassus flabellifer L.).

Methods: The methods include delignification using 10% NaOH, and bleaching using 10% NaOCl. The present research used response surface methodology (RSM) to investigate the impact of temperature and duration on the bleaching process. Two factors were evaluated and optimized using the central composite design (CCD).

Results: The findings revealed that the hit quality and white degree were 91.5% and 52.58% when the temperature and time of bleaching were 40 °C and 30 min, respectively. Utilizing an analysis of variance (ANOVA), the most influential factors on the percentage of strike quality and whiteness degree were identified. Absorption at 3323.34 cm-1 for O-H, 2893.22 cm-1 for C-H, 1371.38 cm-1 for C-O-H, and 1157.28 cm-1 for C-O, according to FTIR characterization results, are characteristic cellulose peaks.

Conclusion: The cellulose characterization results acquired in this work show that the temperature in the bleaching process has a significant effect on the cellulose isolation results.