bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-World Efficacy and Safety of First-Line Nivolumab Plus Chemotherapy in Patients with Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma: A Nationwide Observational Turkish Oncology Group (TOG) Study
Authors: Kutlu Yasin , Dae Shute Ailia , Yilmaz Feride , Erdem Dilek , Sendur Mehmet Ali Nahit , Akbas Sinem , Senocak Tasci Elif , Bas Onur , Dane Faysal , Sakin Abdullah , Kaya Ali Osman , Aykan Musa Baris , Ergun Yakup , Biter Sedat , Disel Umut , Korkmaz Mustafa , Selcukbiricik Fatih , Kose Fatih , Olmez Omer Fatih , Bilici Ahmet , Demir Gokhan , Yalcin Suayib
Published: June 2024

Based on the CheckMate 649 trial, nivolumab plus chemotherapy is the recommended first-line treatment for HER2-negative unresectable advanced or metastatic gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma. This nationwide, multicenter, retrospective study evaluated the real-world effectiveness of this regimen in Turkish patients and identified subgroups that may experience superior outcomes. Conducted across 16 oncology centers in Turkey, this study retrospectively reviewed the clinical charts of adult patients diagnosed with HER2-negative unresectable advanced or metastatic gastric, GEJ, or esophageal adenocarcinoma from 2016 to 2023. This study included 111 patients (54 women, 57 men) with a median age of 58 years. The median progression-free survival (PFS) and overall survival (OS) were 11.7 months and 18.2 months, respectively, whereas the objective response rate (ORR) was 70.3%. Multivariable analyses revealed that previous curative surgery was a favorable independent prognostic factor for both PFS and OS. Conversely, an Eastern Cooperative Oncology Group performance status of 2 emerged as an adverse independent prognostic factor for OS. The safety profile of nivolumab plus chemotherapy was found to be manageable. Our findings support the use of nivolumab plus chemotherapy for the first-line treatment of Turkish patients with HER2-negative unresectable advanced or metastatic gastric, GEJ, or esophageal adenocarcinoma. Patient selection based on clinical characteristics is crucial for optimizing treatment outcomes.
Long-Term Survival and Factors Associated with Increased Mortality in Patients with Ocular Adnexal Lymphomas
Authors: Strianese Diego , Laezza Maria Paola , Tortora Fabio , Fusco Giancarlo , de Divitiis Oreste , D’Aponte Antonella , Briganti Francesco , Elefante Andrea
Published: June 2024

Orbital and ocular adnexal lymphoma (OAL) affects the orbit and the surrounding structures and can arise as several subtypes with variable prognoses. We performed an observational study on the relationship between OAL subtype, diagnostic features, and prognosis to offer valuable insights into imaging techniques, such as Positron Emission Tomography with 2-deoxy-2-[fluorine-18] fluoro-D-glucose integrated with Computed Tomography (18F-FDG PET-CT), in predicting outcomes. With this aim, we retrospectively reviewed 99 patients with OALs, recording demographics, cancer subtype, location and treatment, 18FDG avidity, and bone marrow positivity. We divided patients into Group 1 (those presenting with extranodal marginal zone lymphoma—EMZL) and Group 2, including all other subtypes. The primary outcome was long-term cancer-specific survival (CSS) based on key predictors, performed through Kaplan–Meier curves and the log-rank test, with a p < 0.05 significance threshold. The mean patient age was 67 years (57–75.5). The most frequent histopathologic subtypes were EMZL lymphoma in 69 patients (69.7%), small lymphocytic lymphoma (11.1%) and diffuse-large B-cell lymphoma (10.1%). Patients of Group 1 showed a better prognosis (CSS = 80%) compared to those of Group 2 (CSS = 60%) (p = 0.01). In patients with high-grade lymphoma, the occurrence of 18FDG avidity (p = 0.003) and bone marrow positivity (p = 0.005) were related to a worse prognosis. In our group, EMZL was the most prominent subtype of OALs and exhibited the best prognosis, low 18FDG avidity, and bone marrow negativity. By observing specific patterns in radiological findings, it is possible to increase our understanding of disease progression, treatment response, and the overall prognosis in OAL patients.
Non-Invasive Markers for the Detection of Gastric Precancerous Conditions
Authors: Romańczyk Marcin , Osmola Malgorzata , Link Alexander , Druet Amaury , Hémont Caroline , Martin Jerome , Chapelle Nicolas , Matysiak-Budnik Tamara
Published: June 2024

Gastric cancer (GC) is still one of the most prevalent cancers worldwide, with a high mortality rate, despite improvements in diagnostic and therapeutic strategies. To diminish the GC burden, a modification of the current diagnostic paradigm, and especially endoscopic diagnosis of symptomatic individuals, is necessary. In this review article, we present a broad review and the current knowledge status on serum biomarkers, including pepsinogens, gastrin, Gastropanel®, autoantibodies, and novel biomarkers, allowing us to estimate the risk of gastric precancerous conditions (GPC)—atrophic gastritis and gastric intestinal metaplasia. The aim of the article is to emphasize the role of non-invasive testing in GC prevention. This comprehensive review describes the pathophysiological background of investigated biomarkers, their status and performance based on available data, as well as their clinical applicability. We point out future perspectives of non-invasive testing and possible new biomarkers opportunities.
Induced Pluripotent Stem Cells and CRISPR-Cas9 Innovations for Treating Alpha-1 Antitrypsin Deficiency and Glycogen Storage Diseases
Authors: Walsh Colin , Jin Sha
Published: June 2024

Human induced pluripotent stem cell (iPSC) and CRISPR-Cas9 gene-editing technologies have become powerful tools in disease modeling and treatment. By harnessing recent biotechnological advancements, this review aims to equip researchers and clinicians with a comprehensive and updated understanding of the evolving treatment landscape for metabolic and genetic disorders, highlighting how iPSCs provide a unique platform for detailed pathological modeling and pharmacological testing, driving forward precision medicine and drug discovery. Concurrently, CRISPR-Cas9 offers unprecedented precision in gene correction, presenting potential curative therapies that move beyond symptomatic treatment. Therefore, this review examines the transformative role of iPSC technology and CRISPR-Cas9 gene editing in addressing metabolic and genetic disorders such as alpha-1 antitrypsin deficiency (A1AD) and glycogen storage disease (GSD), which significantly impact liver and pulmonary health and pose substantial challenges in clinical management. In addition, this review discusses significant achievements alongside persistent challenges such as technical limitations, ethical concerns, and regulatory hurdles. Future directions, including innovations in gene-editing accuracy and therapeutic delivery systems, are emphasized for next-generation therapies that leverage the full potential of iPSC and CRISPR-Cas9 technologies.
The Role of Licorice Chalcones as Molecular Genes and Signaling Pathways Modulator—A Review of Experimental Implications for Nicotine-Induced Non-Small Cell Lung Cancer Treatment
Authors: Alsharairi Naser A.
Published: June 2024

Lung cancer (LC) represents the leading cause of global cancer deaths, with cigarette smoking being considered a major risk factor. Nicotine is a major hazardous compound in cigarette smoke (CS), which stimulates LC progression and non-small cell lung cancer (NSCLC) specifically through activation of the nicotinic acetylcholine receptor (α7nAChR)-mediated cell-signaling pathways and molecular genes involved in proliferation, angiogenesis, and metastasis. Chalcones (CHs) and their derivatives are intermediate plant metabolites involved in flavonol biosynthesis. Isoliquiritigenin (ILTG), licochalcone A–E (LicoA–E), and echinatin (ECH) are the most common natural CHs isolated from the root of Glycyrrhiza (also known as licorice). In vitro and/or vivo experiments have shown that licorice CHs treatment exhibits a range of pharmacological effects, including antioxidant, anti-inflammatory, and anticancer effects. Despite advances in NSCLC treatment, the mechanisms of licorice CHs in nicotine-induced NSCLC treatment remain unknown. Therefore, the aim of this paper is to review experimental studies through the PubMed/Medline database that reveal the effects of licorice CHs and their potential mechanisms in nicotine-induced NSCLC treatment.
Unlocking the Potential: Semaglutide’s Impact on Alzheimer’s and Parkinson’s Disease in Animal Models
Authors: Meca Andreea Daniela , Boboc Ianis Kevyn Stefan , Mititelu-Tartau Liliana , Bogdan Maria
Published: June 2024

Semaglutide (SEM), a glucagon-like peptide-1 receptor agonist, has garnered increasing interest for its potential therapeutic effects in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). This review provides a comprehensive description of SEM’s mechanism of action and its effects in preclinical studies of these debilitating conditions. In animal models of AD, SEM has proved beneficial effects on multiple pathological hallmarks of the disease. SEM administration has been associated with reductions in amyloid-beta plaque deposition and mitigation of neuroinflammation. Moreover, SEM treatment has been shown to ameliorate behavioral deficits related to anxiety and social interaction. SEM-treated animals exhibit improvements in spatial learning and memory retention tasks, as evidenced by enhanced performance in maze navigation tests and novel object recognition assays. Similarly, in animal models of PD, SEM has demonstrated promising neuroprotective effects through various mechanisms. These include modulation of neuroinflammation, enhancement of mitochondrial function, and promotion of neurogenesis. Additionally, SEM has been shown to improve motor function and ameliorate dopaminergic neuronal loss, offering the potential for disease-modifying treatment strategies. Overall, the accumulating evidence from preclinical studies suggests that SEM holds promise as a novel therapeutic approach for AD and PD. Further research is warranted to elucidate the underlying mechanisms of SEM’s neuroprotective effects and to translate these findings into clinical applications for the treatment of these devastating neurodegenerative disorders.
Gastropod Allergy: A Comprehensive Narrative Review
Authors: Mederos-Luis Elena , Poza-Guedes Paloma , Pineda Fernando , Sánchez-Machín Inmaculada , González-Pérez Ruperto
Published: June 2024

Food allergies have increased significantly in recent decades, with shellfish being a leading cause of food allergy and anaphylaxis worldwide, affecting both children and adults. The prevalence of shellfish allergies is estimated to be approximately 0.5–2.5% of the general population, varying significantly by geographical location, age, and consumption habits. Although mollusk consumption has risen, the prevalence of mollusk allergies remains unknown. While extensive research has focused on crustacean allergies, mollusk allergies, particularly those related to gastropods, have received comparatively less attention. Clinical manifestations of shellfish allergy range from localized symptoms to life-threatening systemic reactions, such as anaphylaxis. Notably, severe bronchospasm is a predominant clinical feature in cases involving gastropods. Several allergens have been identified in mollusks, including paramyosin, tropomyosin, and sarcoplasmic calcium-binding protein. In gastropods, documented allergens include tropomyosin, paramyosin, the heavy chain of myosin, and Der p 4 amylase. Diagnosis typically involves a thorough clinical history, skin testing, in vitro quantification of immunoglobulin (Ig) E, and confirmation through an oral challenge, although the latter is reserved for selected cases. This narrative review highlights the limited research on gastropod allergy. It provides a comprehensive list of purified and recombinant allergens and discusses the applications of component-resolved diagnosis as well as current therapeutic developments.
MASLD-Related HCC: A Comprehensive Review of the Trends, Pathophysiology, Tumor Microenvironment, Surveillance, and Treatment Options
Authors: Shi Yuming , Taherifard Erfan , Saeed Ali , Saeed Anwaar
Published: June 2024

Hepatocellular carcinoma (HCC) represents a significant burden on global healthcare systems due to its considerable incidence and mortality rates. Recent trends indicate an increase in the worldwide incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and a shift in the etiology of HCC, with MASLD replacing the hepatitis B virus as the primary contributor to new cases of HCC. MASLD-related HCC exhibits distinct characteristics compared to viral HCC, including unique immune cell profiles resulting in an overall more immunosuppressive or exhausted tumor microenvironment. Furthermore, MASLD-related HCC is frequently identified in older age groups and among individuals with cardiometabolic comorbidities. Additionally, a greater percentage of MASLD-related HCC cases occur in noncirrhotic patients compared to those with viral etiologies, hindering early detection. However, the current clinical practice guidelines lack specific recommendations for the screening of HCC in MASLD patients. The evolving landscape of HCC management offers a spectrum of therapeutic options, ranging from surgical interventions and locoregional therapies to systemic treatments, for patients across various stages of the disease. Despite ongoing debates, the current evidence does not support differences in optimal treatment modalities based on etiology. In this study, we aimed to provide a comprehensive overview of the current literature on the trends, characteristics, clinical implications, and treatment modalities for MASLD-related HCC.
Stable Production of a Tethered Recombinant Eel Luteinizing Hormone Analog with High Potency in CHO DG44 Cells
Authors: Byambaragchaa Munkhzaya , Park Sei Hyen , Kim Sang-Gwon , Shin Min Gyu , Kim Shin-Kwon , Hur Sung-Pyo , Park Myung-Hum , Kang Myung-Hwa , Min Kwan-Sik
Published: June 2024

We produced a recombinant eel luteinizing hormone (rec-eel LH) analog with high potency in Chinese hamster ovary DG44 (CHO DG44) cells. The tethered eel LH mutant (LH-M), which had a linker comprising the equine chorionic gonadotropin (eLH/CG) β-subunit carboxyl-terminal peptide (CTP) region (amino acids 115 to 149), was inserted between the β-subunit and α-subunit of wild-type tethered eel LH (LH-wt). Monoclonal cells transfected with the tethered eel LH-wt and eel LH-M plasmids were isolated from five to nine clones of CHO DG44 cells, respectively. The secreted quantities abruptly increased on day 3, with peak levels of 5000–7500 ng/mL on day 9. The molecular weight of tethered rec-eel LH-wt was 32–36 kDa, while that of tethered rec-eel LH-M increased to approximately 38–44 kDa, indicating the detection of two bands. Treatment with the peptide N-glycanase F decreased the molecular weight by approximately 8 kDa. The oligosaccharides at the eCG β-subunit O-linked glycosylation sites were appropriately modified post-translation. The EC50 value and maximal responsiveness of eel LH-M increased by approximately 2.90- and 1.29-fold, respectively, indicating that the mutant exhibited more potent biological activity than eel LH-wt. Phosphorylated extracellular regulated kinase (pERK1/2) activation resulted in a sharp peak 5 min after agonist treatment, with a rapid decrease thereafter. These results indicate that the new tethered rec-eel LH analog had more potent activity in cAMP response than the tethered eel LH-wt in vitro. Taken together, this new eel LH analog can be produced in large quantities using a stable CHO DG44 cell system.
Antidepressant Effect of Enzymatic Porcine Placenta Hydrolysate in Repeated Immobilization Stress-Induced Ovariectomized Female Mice
Authors: Ye Minsook , Nguyen Sharon , Kim Min , Hwang Jee , Bae Gun , Yang Keun-Hang , Shim Insop
Published: June 2024

When postmenopausal women are under stress conditions, this exacerbates mood disorders and issues with neuroimmune systems. The porcine placenta is known to relieve menopausal depression in clinical trials, but its underlying mechanisms for depression and anti-inflammatory functions remain poorly defined. The present study was designed to examine the anti-inflammatory effects of enzymatic porcine placenta hydrolysate (EPPH) on LPS-induced levels of nitric oxide (NO), prostaglandin E2 (PGE2), corticosterone (CORT), and pro-inflammatory cytokine interleukin-1 beta (IL-1β) in RAW 264.7 macrophage cells. In addition, the neurite outgrowth of PC12 cells was evaluated to examine the effects of EPPH on neurite growth. To mimic the symptoms of women with menopause-related depression, a stressed ovariectomized (OVX) female mouse model was used to evaluate the antidepressant effects of EPPH. The female mice were randomly divided into five groups: (1) the sham-operated (Sham) group, (2) the OVX + repeated stress + saline-treated (OVX + ST) group, (3) the OVX + repeated stress + estradiol (0.2 mg/kg)-treated (positive control) group, (4) the OVX + repeated stress + EPPH (300 mg/kg)-treated (300) group, and (5) the OVX + repeated stress + EPPH (1500 mg/kg)-treated (1500) group. Female mice were OVX and repeatedly immobilization-stressed for 2 weeks (2 h/day). A tail suspension test was conducted on the 13th day, followed by the forced swimming test on the 14th day to assess the antidepressant effects of EPPH. After the behavioral tests, the levels of CORT, PGE2, and IL-1β were evaluated. In addition, c-Fos expression in the paraventricular nucleus (PVN) was evaluated using immunohistochemistry. The concentrations of NO, PGE2, and IL-1β stimulated by LPS were significantly reduced via the addition of EPPH to RAW 264.7 cells. EPPH significantly promoted neurite outgrowth in PC12 cells compared to that of the controls. In the tail suspension test, the duration of immobility was reduced in mice treated with EPPH 1500 compared to the OVX + ST group. The EPPH 1500 group had significantly decreased levels of c-Fos-positive neurons in the PVN and reduced levels of CORT and IL-1β in the serum of the Sham group. These results suggested that the high dose of EPPH administration induced the antidepressant-like effect in the ovariectomized mice with repeated stress via downregulating the levels of CORT, IL-1β, and PGE2 in the serum through reducing the expression of c-Fos in the PVN regions.
Molecular Biomarkers of Canine Reproductive Functions
Authors: Mogielnicka-Brzozowska Marzena , Cichowska Aleksandra Wiktoria
Published: June 2024

The aim of the current study is to review potential molecular biomarker substances selected so far as useful for assessing the quality of dog semen. Proteins, lipids, carbohydrates, and ions can serve as molecular biomarkers of reproductive functions (BRFs) for evaluating male reproductive health and identifying potential risk factors for infertility or reproductive disorders. Evaluation of BRF levels in semen samples or reproductive tissues may provide insights into the underlying causes of infertility, such as impaired sperm function, abnormal sperm–egg interaction, or dysfunction of the male reproductive tract. Molecular biomarker proteins may be divided into two groups: proteins that are well-studied, such as A-kinase anchoring proteins (AKAPs), albumins (ALBs), alkaline phosphatase (ALPL), clusterin (CLU), canine prostate-specific esterase (CPSE), cysteine-rich secretory protein 2 (CRISP2), lactotransferrin (LTF), metalloproteinases (MMPs), and osteopontin (OPN) and proteins that are not well-studied. Non-protein markers include lipid-based substances (fatty acids, phosphatidylcholine), carbohydrates (glycosaminoglycans), and ions (zinc, calcium). Assessing the levels of BRFs in semen samples may provide valuable information for breeding management and reproductive assessments in dogs. This review systematizes current knowledge that could serve as a starting point for developing practical tests with the use of biomarkers of canine reproductive functions and their predictive value for assisted reproductive technique outcomes and semen preservation.
Productive and Qualitative Traits of Sorghum Genotypes Used for Silage under Tropical Conditions
Authors: Oliveira Risalvo F. , Perazzo Alexandre F. , dos S. Pina Douglas , Alba Henry D. R. , Leite Vagner M. , dos Santos Manoel M. , Santos Edson M. , de A. Sobrinho Luiz E. C. , Pinheiro Ricardo L. S. , Aquino Elielson L. , de Carvalho Gleidson G. P.
Published: June 2024

The aim of this study was to evaluate the productive potential, chemical composition, and fermentation profile of 24 genotypes of forage sorghum after ensiling. For this agronomic evaluation, a completely randomized block design with six replicates and twenty-four treatments was employed. Genotype 5 had the highest dry matter (DM) yield of 22.24 t/ha. The plant DM content ranged (p < 0.001) from 271.8 g/kg of fresh matter (FM) in genotype 9 to 330.0 g/kg FM in genotype 3, averaging 302.9 g/kg FM. The crude protein and non-fibrous carbohydrates differed significantly (p < 0.001) in the evaluated silages, with mean values of 61.0 and 275.3 g/kg DM, respectively. The pH of the sorghum silages also differed (p < 0.001), despite having an average of 3.94, with values ranging from 3.68 to 4.27. No changes were observed (p > 0.05) for the dry matter recovery of the sorghum genotype silages, which averaged at 853.9 g/kg FM. In the present study, genotype 5 resulted in being the most recommended genotype because it demonstrated a higher yield and higher nutritional value in both its fresh form and its ensiled form; had the lowest losses; and showed an ideal dry matter recovery after ensiling of 880 g/kg.
Durable Objective Response to Lurbinectedin in Small Cell Bladder Cancer with TP53 Mutation: A Molecular-Directed Strategy
Authors: Moussa Mohammad Jad , Khandelwal Jaanki , Wilson Nathaniel R. , Naik Sagar A. , Subbiah Vivek , Campbell Matthew T. , Msaouel Pavlos , Singh Parminder , Alhalabi Omar
Published: June 2024

Small cell bladder cancer (SCBC) is a rare and aggressive disease, often treated with platinum/etoposide-based chemotherapy. Key molecular drivers include the inactivation of onco-suppressor genes (TP53, RB1) and amplifications in proto-oncogenes (MYC). We report a patient with SCBC who achieved an objective and prolonged response to lurbinectedin, which has been approved for metastatic small cell lung cancer, after developing disease progression on cisplatin/etoposide and nivolumab/ipilimumab. A genomic analysis of a metastatic biopsy prior to lurbinectedin initiation revealed a TP53 mutation and amplification of the cell cycle regulators E2F3 and MYCL. A repeat biopsy following the development of lurbinectedin resistance showed a new actionable ERBB2 alteration without significant change in the tumor mutation burden (six mutations/Mb). The present report suggests that lurbinectedin may be active and should be further explored in SCBC harboring TP53 mutations and amplifications in E2F3 and MYC family complexes.
Attitudes toward Death among Health Care Professionals in the Balkan Region
Authors: Kovacevic Tomi , Zaric Bojan , Djekic Malbasa Jelena , Bokan Darijo , Nikolin Borislava , Bursac Daliborka , Simurdic Petar , Stojsic Vladimir , Stojanovic Goran , Maric Dragana
Published: June 2024

Background and Objectives: Death is an unavoidable experience in any person’s life and affects not only the dying person but also their caregivers. The dying process has been displaced from homes to health care facilities in the majority of cases. Facing death and dying has become an everyday life of health care professionals (HCP), especially in palliative care (PC) settings. This study aimed to investigate the death attitudes among HCPs in Serbia. Materials and Methods: The Serbian version of the Death Attitude Profile-Revised (DAP-RSp) was used as a measurement instrument. Results: The average age of the 180 included participants was 42.2 ± 9.9 years; the majority were females (70.0%), with more than 10 years of working experience (73.0%), physicians (70.0%) and those working in a non-oncological (non-ONC) field (57.78%). The mean total score of DAP-RSp was 124.80 ± 22.44. The highest mean score was observed in the neutral acceptance dimension (NA) (5.82 ± 0.90) and lowest in the Escape acceptance (EA) (2.57 ± 1.21). Higher negative death attitudes were reported among nurses compared to physicians (p = 0.002). Statistically significant differences were observed in the fear of death (FD) and death avoidance (DA) domains, favoring PC specialists and oncologists (p = 0.004; p = 0.015). Physicians working in Oncology (ONC) showed lower FD values (p = 0.001) compared to non-ONC departments. Conclusions: Attitudes toward death among HCPs are of great importance for the well-being of both HCPs and patients. Negative attitudes can lead to deficient care. The fear of death is highly represented among Serbian HCPs working in non-ONC fields, including both nurses and physicians. This study emphasizes the need for further research to comprehensively explore and understand HCPs’ attitudes toward death. This research highlights the need for the development of an educational curriculum across all levels of medical education, aimed at overcoming the fear of death and enhancing coping strategies, which will improve the care for patients diagnosed with terminal illnesses.
Effect of Private Deliberation: Deception of Large Language Models in Game Play
Authors: Poje Kristijan , Brcic Mario , Kovac Mihael , Babac Marina Bagic
Published: June 2024

Integrating large language model (LLM) agents within game theory demonstrates their ability to replicate human-like behaviors through strategic decision making. In this paper, we introduce an augmented LLM agent, called the private agent, which engages in private deliberation and employs deception in repeated games. Utilizing the partially observable stochastic game (POSG) framework and incorporating in-context learning (ICL) and chain-of-thought (CoT) prompting, we investigated the private agent’s proficiency in both competitive and cooperative scenarios. Our empirical analysis demonstrated that the private agent consistently achieved higher long-term payoffs than its baseline counterpart and performed similarly or better in various game settings. However, we also found inherent deficiencies of LLMs in certain algorithmic capabilities crucial for high-quality decision making in games. These findings highlight the potential for enhancing LLM agents’ performance in multi-player games using information-theoretic approaches of deception and communication with complex environments.
The Relationship among Internet Addiction, Moral Potency, Mindfulness, and Psychological Capital
Authors: Zewude Girum Tareke , Oo Tun Zaw , Józsa Gabriella , Józsa Krisztián
Published: June 2024

This research aimed to contribute to the literature on internet addiction (IA) and moral development among university students. Moral potency (MP) encompasses the interconnected dimensions of moral courage, moral ownership, and moral efficacy. Studies on the relationships between students’ problematic behaviors (e.g., IA) and cognitive processes like MP, mindfulness (MI), and psychological capital (PsyCap) are scarce in educational research. Therefore, this study investigated the relationships among IA, MP, MI, and PsyCap in university students. This study included 868 undergraduate students from a state university in Ethiopia, with 526 male students (60.6%) and 342 female students (39.4%). Participants’ ages ranged from 21 to 29 years, with a mean age of 22.31 and a standard deviation of 4.03. The findings indicated that IA was negatively correlated with MI, PsyCap, and MP. Both MI and PsyCap showed positive correlations with MP. Importantly, this study revealed that IA had a direct and negative impact on MI, PsyCap, and MP. Further, MI and PsyCap partially mediated and fully mediated the relationship between IA and MP. These findings suggest that cultivating MI and positive PsyCap among university students could be an important strategy to reduce the risks of IA and enhance their moral development. This study contributes to the limited research on the complex relationships between technology use, psychological resources, and moral functioning in emerging adulthood.
Improving the Power Efficiency of a Microwave Plasma Source by Using the Principle of a Variable-Impedance Waveguide
Authors: Thosdeekoraphat Thanaset , Kotchapradit Supawat , Bunpradit Watcharapong , Boonpeang Worawut , Thongsopa Chanchai , Santalunai Samran
Published: June 2024

Microwave plasma sources are used in various applications, but inefficiency can limit their usefulness. Researchers have investigated a new approach with which to improve efficiency by using a waveguide with a special tuner. A standard waveguide was compared to one equipped with a stub tuner, which allows for the fine-tuning of the electrical properties. The experiment used a frequency of 2.45 GHz and tested input powers of 1 kW and 1.5 kW. Experiments showed that waveguides with tuners transferred power more efficiently, with fewer reflected and more transmitted microwaves. While peak temperatures remained similar, the tuned waveguide produced a hotter plasma flame (30–60 °C) at the same distance. Notably, increasing the input power further boosted the flame temperature by 300 °C. These findings suggest that stub tuners can significantly improve the efficiency of microwave plasma sources. This paves the way for more efficient plasma generation technologies and potentially allows for applications requiring even higher power.
Single-Stage MV-Connected Charger Using an Ac/Ac Modular Multilevel Converter
Authors: Marca Ygor Pereira , Roes Maurice G. L. , Wijnands Cornelis G. E. , Duarte Jorge L. , Huisman Henk
Published: June 2024

Modular multilevel converters with non-sinusoidal ac voltage output can reduce cost and volume in medium-voltage-connected electric vehicle battery charging applications. The use of full-bridge submodules in such converters enables single-stage ac/ac voltage conversion, allowing a medium-voltage grid to be directly connected to a medium-frequency isolation transformer. The application of a square wave voltage at the medium-frequency transformer’s single-phase port enhances the converter’s efficiency and power density in comparison to a sinusoidal voltage. This paper presents the analysis and modelling of a modular multilevel converter, comparing its operation with sinusoidal and square wave output voltages. A single control scheme for both output voltage waveforms is proposed for the three-phase and single-phase ac currents, circulating currents, and the energy stored in the submodule capacitors. The control strategy of the three-phase and single-phase port currents is verified through simulation and experiments using a scaled-down prototype, thereby validating its suitability for high-power bidirectional battery chargers.
A Review of Event-Based Conceptual Rainfall-Runoff Models: A Case for Australia
Authors: Ali Sabrina , Rahman Ataur , Shaik Rehana
Published: June 2024

Event-based models focus on modelling of peak runoff from rainfall data. Conceptual models indicate simplified models that provide reasonably accurate answers despite their crude nature. Rainfall-runoff models are used to transform a rainfall event into a runoff event. This paper focuses on reviewing computational simulation of rainfall-runoff processes over a catchment. Lumped conceptual, event-based rainfall-runoff models have remained the dominant practice for design flood estimation in Australia for many years due to their simplicity, flexibility, and accuracy under certain conditions. Attempts to establish regionalization methods for prediction of design flood hydrographs in ungauged catchments have seen little success. Therefore, as well as reviewing key rainfall-runoff model components for design flood estimation with a special focus on event-based conceptual models, this paper covers the aspects of regionalization to promote their applications to ungauged catchments.
Benefits of Badminton for Preventing Cognitive Decline and Dementia
Authors: Oishi Ayame , Yamasaki Takao
Published: June 2024

Badminton is one of the most popular racket sports played by all age groups worldwide. Anyone can practice and play badminton as a leisure or competitive sport, regardless of age, experience, or skill level. It does not require physical contact among players or expensive equipment. Compared with closed-skill exercises (e.g., running and swimming), open-skill exercises (e.g., badminton and table tennis) have been reported to significantly improve cognitive function and prevent cognitive decline. This mini review aimed to investigate the findings related to badminton intervention for cognitive function, with attention to the modifiable risk factors of dementia in adults. Additionally, we outlined the characteristics of badminton’s physical demands. This narrative review encompassed studies reported from 2013 to 2023 from multiple databases, including PubMed and Google Scholar. Keywords such as “badminton”, “dementia”, “cognitive function”, “physical activity”, and “depression” were used to identify relevant articles. Various studies, including randomized controlled trials, cohort studies, and case–control studies, were selected to provide a comprehensive overview of badminton intervention. Quantitative data analysis suggests that at a cognitive level, high-intensity badminton can enhance cognitive function with at least 10 min of play once weekly or 20 min of play once weekly on average, whereas moderate-intensity badminton can be effective when played for at least 30 min once weekly or 35 min twice weekly on average. For modifiable risk factors, recreational badminton for about 3 h weekly could effectively manage blood pressure. For body fat percentage and fasting serum glucose levels, recreational badminton for about 10 h weekly exerted positive effects. For depressive states, a moderate-intensity badminton program for 100 min weekly was effective. For lipid profiles associated with dementia occurrence, prolonged badminton intervention for more than 3 months may be beneficial. The characteristics presented here indicate that intervention with regular badminton exercise could effectively improve cognitive function and prevent cognitive decline in older adults.
Analyzing the Eucalyptus Timber Value Chain in Thailand: Profit Distribution and Opportunities for Improvement
Authors: Premashthira Aerwadee , Tangkit Kitipong , Lamaisri Warayost , Kaakkurivaara Nopparat , Na Takuathung Chakrit , Neimsuwan Trairat , Jumwong Narinthorn , Meunpong Ponthep , Kaakkurivaara Tomi
Published: June 2024

The Thai forestry sector relies greatly on Eucalyptus as a raw material. The rapid expansion of plantations during the last few decades and the high demand for Eucalyptus for several purposes has led to numerous supply chain practices. A comprehensive understanding of the Eucalyptus value chain is lacking in Thailand, which has consequences for optimization, sustainability, and profitability aspects. This study analyzed actors and their activities along the value chain and estimated added value and profit margin benefit distributions. The study method involved a value chain analysis approach, whereby input data were collected from the following groups: seedling suppliers and developers, farmers and tree growers, timber traders and collectors, intermediaries, processors, wholesalers, and consumers via key informant interviews, in-depth interviews, and group discussions. The results revealed the vertical integration of Eucalyptus timber businesses, where sapling breeders were the major input suppliers with a significant role in the value chain based on the role of controlling the majority of seedling production, promoting cultivation, and ensuring the raw material supply for the pulp industry through a full-cycle membership program. Total gross marketing margin was highest (90.6%) in the path of the pulp mill industry and lowest in the path of the biomass power plant (73.4%). The profit share of growers varied between 9.9% and 26.6% depending on the path and chain. The overall benefit distribution analysis demonstrated a positive gross profit margin but minor distribution to the growers. Our study determined that decision-makers should create supportive programs, funding opportunities, and infrastructural support for research and development, capacity building, and regulation to ensure suitable benefits for all actors in the Eucalyptus timber value chain in Thailand.
The Potential Distribution Prediction of the Forestry Pest Cyrtotrachelus buqueti (Guer) Based on the MaxEnt Model across China
Authors: Fu Chun , Wang Zhiling , Peng Yaqin , Zhuo Zhihang
Published: June 2024

Exploring the geographical distribution of forestry pests is crucial for formulating pest management strategies. Cyrtotrachelus buqueti (Guer) stands out as one of the primary pests among China’s forestry hazards. This study employs the MaxEnt model, along with 19 bioclimatic variables and habitat characteristics, to predict the current and future distribution of C. buqueti under three typical emission scenarios for 2050 and 2070 (2.6 W/m2 (SSP1-2.6), 7.0 W/m2 (SSP3-7.0), and 8.5 W/m2 (SSP5-8.5)). Among the 19 bioclimatic variables, BIO 14 (precipitation of the driest month), BIO 8 (mean temperature of the wettest quarter), Elev, slope, and aspect were identified as significant contributors. These five variables are critical environmental factors affecting the suitability of habitats for C. buqueti and are representative of its potential habitat. The results indicate that C. buqueti predominantly inhabits southern regions such as Chongqing, Guizhou, Yunnan, Sichuan, Guangxi, Shaanxi, Hubei, Hainan, and Taiwan. Among them, Chongqing, Guizhou, and Yunnan are the primary distribution areas of high suitability. In the future, the centroid’s movement direction will generally shift southward, with an expansion trend observed in the distribution areas of each province. This study enhances researchers’ understanding of forestry pest dynamics and promotes proactive management strategies to mitigate their impact on forest ecosystems and agricultural productivity.
Physicochemical Characterization of In Situ Annealed Starch and Its Application in a Fermented Dairy Beverage
Authors: de Oliveira Luma Sarai , Cordon Cardona Andres David , Freitas Cardines Pedro Henrique , de Barros Márcio , Bosso Tomal Adriana Aparecida , de Souza Rocha Thais
Published: June 2024

In this study, the aim was to modify the starches of three different sweet potato varieties—Rosada Uruguaiana (RU), Rosada Canadense (RC), and Ligeirinha (L)—through in situ annealing to increase the content of slowly digestible starch (SDS), which has health benefits. The modified carbohydrate was then added to a dairy beverage fermented by Lactobacillus casei 1e (L. casei). After annealing, the starches had different physicochemical properties, and the L variety, which had the highest SDS content, was chosen for the formulation of the fermented dairy beverage. Two concentrations of modified starch (7% and 10.5%) were used in the formulations, and a sensory analysis indicated no differences in acceptance and purchase intention. The beverage containing 10.5% modified starch exhibited good physicochemical and microbiological stability. This study demonstrates the possibility of creating a functional fermented dairy beverage with high SDS content, which could potentially benefit consumers’ health.
Quantum Brain Dynamics: Optical and Acoustic Super-Radiance via a Microtubule
Authors: Nishiyama Akihiro , Tanaka Shigenori , Tuszynski Jack A.
Published: June 2024

We aim to derive a super-radiance solution of coherent light and sound waves involving water degrees of freedom in the environment of a microtubule. We introduce a Lagrangian density functional of quantum electrodynamics with non-relativistic charged bosons as a model of quantum brain dynamics (QBD) involving water molecular conformational states and photon fields. We also introduce the model of charged boson fields (water degrees of freedom) coupled with phonons. Both optical and acoustic super-radiance solutions are derived in our approach. An acoustic super-radiance mechanism involving information transfer is proposed as an additional candidate to solve the binding problem and to achieve acoustic holography. Our results can be applied to achieve holographic memory storage and information processing in QBD.
Blau Syndrome: Challenging Molecular Genetic Diagnostics of Autoinflammatory Disease
Authors: Brichova Michaela , Klimova Aneta , Heissigerova Jarmila , Svozilkova Petra , Vaneckova Manuela , Dolezalova Pavla , Nemcova Dana , Michalickova Marcela , Jedlickova Jana , Dudakova Lubica , Liskova Petra
Published: June 2024

The aim of this study was to describe the clinical and molecular genetic findings in seven individuals from three unrelated families with Blau syndrome. A complex ophthalmic and general health examination including diagnostic imaging was performed. The NOD2 mutational hot spot located in exon 4 was Sanger sequenced in all three probands. Two individuals also underwent autoinflammatory disorder gene panel screening, and in one subject, exome sequencing was performed. Blau syndrome presenting as uveitis, skin rush or arthritis was diagnosed in four cases from three families. In two individuals from one family, only camptodactyly was noted, while another member had camptodactyly in combination with non-active uveitis and angioid streaks. One proband developed two attacks of meningoencephalitis attributed to presumed neurosarcoidosis, which is a rare finding in Blau syndrome. The probands from families 1 and 2 carried pathogenic variants in NOD2 (NM_022162.3): c.1001G>A p.(Arg334Gln) and c.1000C>T p.(Arg334Trp), respectively. In family 3, two variants of unknown significance in a heterozygous state were found: c.1412G>T p.(Arg471Leu) in NOD2 and c.928C>T p.(Arg310*) in NLRC4 (NM_001199139.1). In conclusion, Blau syndrome is a phenotypically highly variable, and there is a need to raise awareness about all clinical manifestations, including neurosarcoidosis. Variants of unknown significance pose a significant challenge regarding their contribution to etiopathogenesis of autoinflammatory diseases.
Genome-Wide Identification of WRKY Transcription Factor Family in Chinese Rose and Response to Drought, Heat, and Salt Stress
Authors: Yan Xinyu , Zhao Jiahui , Huang Wei , Liu Cheng , Hao Xuan , Gao Chengye , Deng Minghua , Wen Jinfen
Published: June 2024

The WRKY gene family is a key transcription factor family for plant development and the stress response. However, few studies have investigated the WRKY gene family in Chinese rose (Rosa chinensis). In this study, 68 RcWRKY genes were identified from the Chinese rose genome and classified into three primary groups and five subgroups based on the structural and phylogenetic characteristics. The analysis of the conserved domains, motifs, and gene structure revealed that the RcWRKY genes within the same group had the same exon–intron organization and composition. Chromosome mapping and gene duplication revealed that the RcWRKY genes were randomly dispersed across seven chromosomes. Fragment duplication and refined selection may have influenced the evolution of the WRKY gene family in Chinese rose. The cis-acting elements in the WRKY promoter region revealed that the RcWRKY genes contained numerous abiotic stress response elements. The results of qRT-PCR revealed that the expression of RcWRKY was tissue-specific, with high expression being observed under drought, heat, and salt stress. Notably, RcWRKY49′s expression increased more than fivefold following salt stress, indicating that it is a crucial gene mediating the salt stress response of Chinese rose. These findings shed light on the regulatory role of RcWRKY in the growth and development of Chinese rose, and they serve as a foundation for future molecular breeding programs and gene discovery.
Combined Effect of the Microstructure and Mechanical Behavior of Lateritic Soils in the Instability of a Road Cut Slope in Rwanda
Authors: Valentino Roberto , Pizzati Mattia , Mizero Jules
Published: June 2024

A very common hazard in Rwanda is represented by the instability of steep road cut slopes in lateritic soil. In its natural state, this material appears as a fine-grained weak and altered rock, generally in unsaturated conditions. Steep cut slopes made by this material could remain stable for a long time unless weathering weakens its mechanical behavior and heavy rainfall provokes a rapid landslide. This paper presents the results of an experimental investigation on the microstructural, petrophysical, and geotechnical properties of lateritic soil from a road cut slope located in Kabaya (Ngororero District—Rwanda), which was recently subjected to a landslide. The mechanical properties of the material are strictly related to the geological origin and history of the deposits, their formation environment, and weathering processes. These characteristics were revealed by peculiar microstructural features (micro-texture, porosity, and degree of alteration of original mineral paragenesis). The experimental investigations included identification and classification tests, direct shear tests on saturated samples, and swelling tests. This multidisciplinary approach provided insights into the relationship between geotechnical properties and the microstructural, petrophysical, and chemical characteristics of the altered rocks. This study showed how different levels of chemical alteration operated by weathering processes, in conjunction with brittle deformation related to the tectonic history, formed in the same site two shallow rock layers with similar macro-scale features and mechanical behaviors but markedly different microstructural and chemical properties. The innovative aspect of this research suggests an integrated multidisciplinary approach to considering microstructural aspects in addition to mechanical behavior in the slope stability analyses in lateritic soil. In particular, this study demonstrates the importance of such an approach since the failure mechanism is better explained if it is based on microstructural observations instead of considering the soil shear strength parameters only. This research helped to explain the formation of the landslide failure mechanism in a specific road cut slope, which could be assumed as representative of many other similar slopes subjected to landslides in Rwanda.
3D Numerical Modeling of Geosynthetics for Soil Reinforcement: A Bibliometric Analysis and Literature Review
Authors: Paiva Lucas , Pinho-Lopes Margarida , Paula António Miguel , Valente Robertt
Published: June 2024

Soil reinforcement using geosynthetics is an efficient and cost-effective solution for a variety of geotechnical structures. Along with the increasing use of geosynthetics, there is a need to expand and enhance the design methodologies for these elements, which are still frequently based on conservative limit equilibrium approaches. In this paper, a bibliometric analysis was conducted on geosynthetic-reinforced soil structures (GRS), identifying the state of the art, research trends, and other indicators. The data were obtained from the Scopus platform and processed by VOSViewer v1.6 software. The initial search comprised 552 papers and the screening process selected 516 relevant papers from 1992 to October 2023. The study analyzed the occurrence of publications by year, keyword trends, authors, citations/co-citations, and bibliographic coupling. Then, a focus was given to 3D modeling research on geosynthetics, highlighting the dominant modeling techniques, material properties, and design challenges in GRS. The bibliometric analysis provided a crucial guideline in the identification of relevant papers and research trends, and a series of conclusions were presented regarding the 3D modeling techniques, choice of material properties, and boundary conditions.