bluuebunny/crossref_metadata_2025 huggingface dataset:
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) are localized in the nucleus of retinal Müller glial cells and modulated by cytokines and oxidative stress
Authors: Lee Eun-Jin , Zheng Mengmei , Craft Cheryl Mae , Jeong Shinwu
Published: July 2021

Matrix metalloproteinases (MMPs) are involved in the pathology of numerous inflammatory retinal degenerations, including retinitis pigmentosa (RP). Our previous work revealed that intravitreal injections with tissue inhibitor of metalloproteinases 1 (TIMP-1) reduce the progression of rod cell death and inhibit cone cell remodeling that involves reactive gliosis in retinal Müller glial cells (MGCs) in rodent models. The underlying cellular and molecular mechanisms of how TIMP-1 functions in the retina remain to be resolved; however, MGCs are involved in structural homeostasis, neuronal cell survival and death. In the present study, MMP-9 and TIMP-1 expression patterns were investigated in a human MGC line (MIO-M1) under inflammatory cytokine (IL-1β and TNF-α) and oxidative stress (H2O2) conditions. First, both IL-1β and TNF-α, but not H2O2,have a mildin vitropro-survival effect on MIO-M1 cells. Treatment with either cytokine results in the imbalanced secretion of MMP-9 and TIMP-1. H2O2treatment has little effect on their secretion. The investigation of their intracellular expression led to interesting observations. MMP-9 and TIMP-1 are both expressed, not only in the cytoplasm, but also inside the nucleus. None of the treatments alters the MMP-9 intracellular distribution pattern. In contrast to MMP-9, TIMP-1 is detected as speckles. Intracellular TIMP-1 aggregation forms in the cytoplasmic area with IL-1β treatment. With H2O2treatments, the cell morphology changes from cobbles to spindle shapes and the nuclei become larger with increases in TIMP-1 speckles in an H2O2dose-dependent manner. Two TIMP-1 cell surface receptors, low density lipoprotein receptor-related protein-1 (LRP-1) and cluster of differentiation 82 (CD82), are expressed within the nucleus of MIO-M1 cells. Overall, these observations suggest that intracellular TIMP-1 is a target of proinflammatory and oxidative insults in the MGCs. Given the importance of the roles for MGCs in the retina, the functional implication of nuclear TIMP-1 and MMP-9 in MGCs is discussed.
Melting, smelting, and recycling: A regional study around the Late Bronze Age mining site of Prigglitz-Gasteil, Lower Austria
Authors: Mödlinger Marianne , Trebsche Peter , Sabatini Benjamin
Published: July 2021

This paper presents a study on copper production and distribution in Lower Austria’s southeastern region during the Late Bronze Age (c. 1350–800 BC), with the focal point being the chemistry and isotopic character of artifacts from a small copper mining site at Prigglitz-Gasteil on the Eastern Alps’ easternmost fringe. Ores, casting cakes, and select objects from the Late Bronze Age mining site at Prigglitz-Gasteil, Lower-Austria, and within 15 km of its surroundings, were chemically and isotopically analysed using XRF, NAA, and MC-ICPMS. The importance of Prigglitz-Gasteil as a local mining and metal processing center is evaluated based on the produced data, and the distribution and sourcing of copper-producing materials found at the site are discussed. Special attention is paid to the mixing of scrap and source materials early in the metal production process. The most salient discussions focus on the variability of the chemistry and Pb isotopic ratios of the studied objects, which seem to constitute a multitude of source materials, unlike the pure chalcopyrite-source copper produced from the Prigglitz-Gasteil mine itself. The analytical data suggests that copper alloys were mainly imported from materials originating in the Slovakian Ore Mountains, which were subsequently mixed/recycled with relatively pure locally produced copper. The purity of the copper from Prigglitz-Gasteil was fortuitous in identifying imported copper that contained measurable amounts of Pb and other chemically distinct characteristics. The chaîne opératoire of metal production at the site is mentioned; however, it is clear that additional information on the region’s geochemistry is required before any finite conclusions on the ore-to-metal production can be made.
Intravenous versus inhalational maintenance of anesthesia for quality of recovery in adult patients undergoing non-cardiac surgery: A systematic review with meta-analysis and trial sequential analysis
Authors: Shui Min , Xue Ziyi , Miao Xiaolei , Wei Changwei , Wu Anshi
Published: July 2021

Background

Intravenous and inhalational agents are commonly used in general anesthesia. However, it is still controversial which technique is superior for the quality of postoperative recovery. This meta-analysis aimed at comparing impact of total intravenous anesthesia (TIVA) versus inhalational maintenance of anesthesia on the quality of recovery in patients undergoing non-cardiac surgery.

Methods

We systematically searched EMBASE, PubMed, and Cochrane library for randomized controlled trials (RCTs), with no language or publication status restriction. Two authors independently performed data extraction and assessed risk of bias. The outcomes were expressed as mean difference (MD) with 95% confidence interval (CI) based on a random-effect model. We performed trial sequential analysis (TSA) for total QoR-40 scores and calculated the required information size (RIS) to correct the increased type I error.

Results

A total of 156 records were identified, and 9 RCTs consisting of 922 patients were reviewed and included in the meta-analysis. It revealed a significant increase in total QoR-40 score on the day of surgery with TIVA (MD, 5.91 points; 95% CI, 2.14 to 9.68 points; P = 0.002; I2 = 0.0%). The main improvement was in four dimensions, including “physical comfort”, “emotional status”, “psychological support” and “physical independence”. There was no significant difference between groups in total QoR-40 score (P = 0.120) or scores of each dimension on POD1. The TSA showed that the estimated required information size for total QoR-40 scores was not surpassed by recovered evidence in our meta-analysis. And the adjusted Z-curves did not cross the conventional boundary and the TSA monitoring boundary.

Conclusion

Low-certainty evidence suggests that propofol-based TIVA may improve the QoR-40 score on the day of surgery. But more evidence is needed for a firm conclusion and clinical significance.
Video and acceleration records of streaked shearwaters allows detection of two foraging behaviours associated with large marine predators
Authors: Garrod Aran , Yamamoto Sei , Sakamoto Kentaro Q. , Sato Katsufumi
Published: July 2021

The study of seabird behaviour has largely relied on animal-borne tags to gather information, requiring interpretation to estimate at-sea behaviours. Details of shallow-diving birds’ foraging are less known than deep-diving species due to difficulty in identifying shallow dives from biologging devices. Development of smaller video loggers allow a direct view of these birds’ behaviours, at the cost of short battery capacity. However, recordings from video loggers combined with relatively low power usage accelerometers give a means to develop a reliable foraging detection method. Combined video and acceleration loggers were attached to streaked shearwaters in Funakoshi-Ohshima Island (39°24’N,141°59’E) during the breeding season in 2018. Video recordings were classified into behavioural categories (rest, transit, and foraging) and a detection method was generated from the acceleration signals. Two foraging behaviours, surface seizing and foraging dives, are reported with video recordings. Surface seizing was comprised of successive take-offs and landings (mean duration 0.6 and 1.5s, respectively), while foraging dives were shallow subsurface dives (3.2s mean duration) from the air and water surface. Birds were observed foraging close to marine predators, including dolphins and large fish. Results of the behaviour detection method were validated against video recordings, with mean true and false positive rates of 90% and 0%, 79% and 5%, and 66% and <1%, for flight, surface seizing, and foraging dives, respectively. The detection method was applied to longer duration acceleration and GPS datasets collected during the 2018 and 2019 breeding seasons. Foraging trips lasted between 1 − 8 days, with birds performing on average 16 surface seizing events and 43 foraging dives per day, comprising <1% of daily activity, while transit and rest took up 55 and 40%, respectively. This foraging detection method can address the difficulties of recording shallow-diving foraging behaviour and provides a means to measure activity budgets across shallow diving seabird species.
Psycholinguistic and affective norms for 1,252 Spanish idiomatic expressions
Authors: Gavilán José M. , Haro Juan , Hinojosa José Antonio , Fraga Isabel , Ferré Pilar
Published: July 2021

This study provides psycholinguistic and affective norms for 1,252 Spanish idiomatic expressions. A total of 965 Spanish native speakers rated the idioms in 7 subjective variables: familiarity, knowledge of the expression, decomposability, literality, predictability, valence and arousal. Correlational analyses showed that familiarity has a strong positive correlation with knowledge, suggesting that the knowledge of the figurative meaning of an idiom is highly related to its frequency of use. Familiarity has a moderate positive correlation with final word predictability, indicating that the more familiar an idiom is rated, the more predictable it tends to be. Decomposability shows a moderate positive correlation with literality, suggesting that those idioms whose figurative meaning is easier to deduce from their constituents tend to have a plausible literal meaning. In affective terms, Spanish idioms tend to convey more negative (66%) than positive meanings (33%). Furthermore, valence and arousal show a quadratic relationship, in line with the typical U-shaped relationship found for single words, which means that the more emotionally valenced an idiom is rated, the more arousing it is considered to be. This database will provide researchers with a large pool of stimuli for studying the representation and processing of idioms in healthy and clinical populations.
The Kokel of Southern Siberia: New data on a post-Xiongnu material culture
Authors: Sadykov Timur , Caspari Gino , Blochin Jegor , Lösch Sandra , Kapinus Yulija , Milella Marco
Published: July 2021

From the end of the Xiongnu Empire to the establishment of the first Turkic Khaganate, the territory of Southern Siberia sees the emergence of distinctive local material cultures. The Kokel culture is essentially unknown in the international English-language literature even though archaeological sites pertaining to this material culture are among the most common in Tuva (Southern Siberia). This makes them important for the understanding aspects of the sociocultural dynamics following the collapse of the first “steppe empire”. Here we present the results of the study of a Kokel funerary site recently excavated near the Early Iron Age kurgan Tunnug 1 and discuss the data in the context of the available Soviet and Russian literature. The Kokel culture substantially differs from the material culture of the Xiongnu and has to be seen as a largely independent cultural entity of small tribal groups without a pronounced social hierarchy engaging in frequent violent local conflict.
Self-management for chronic widespread pain including fibromyalgia: A systematic review and meta-analysis
Authors: Geraghty Adam W. A. , Maund Emma , Newell David , Santer Miriam , Everitt Hazel , Price Cathy , Pincus Tamar , Moore Michael , Little Paul , West Rachel , Stuart Beth
Published: July 2021

Background

Chronic widespread pain (CWP) including fibromyalgia has a prevalence of up to 15% and is associated with substantial morbidity. Supporting psychosocial and behavioural self-management is increasingly important for CWP, as pharmacological interventions show limited benefit. We systematically reviewed the effectiveness of interventions applying self-management principles for CWP including fibromyalgia.

Methods

MEDLINE, Embase, PsycINFO, The Cochrane Central Register of Controlled Trials and the WHO International Clinical Trials Registry were searched for studies reporting randomised controlled trials of interventions adhering to self-management principles for CWP including fibromyalgia. Primary outcomes included physical function and pain intensity. Where data were sufficient, meta-analysis was conducted using a random effects model. Studies were narratively reviewed where meta-analysis could not be conducted Evidence quality was rated using GRADE (Grading of Recommendations, Assessment, Development and Evaluations) (PROSPERO-CRD42018099212).

Results

Thirty-nine completed studies were included. Despite some variability in studies narratively reviewed, in studies meta-analysed self-management interventions improved physical function in the short-term, post-treatment to 3 months (SMD 0.42, 95% CI 0.20, 0.64) and long-term, post 6 months (SMD 0.36, 95% CI 0.20, 0.53), compared to no treatment/usual care controls. Studies reporting on pain narratively had greater variability, however, those studies meta-analysed showed self-management interventions reduced pain in the short-term (SMD -0.49, 95% CI -0.70, -0.27) and long-term (SMD -0.38, 95% CI -0.58, -0.19) compared to no treatment/usual care. There were few differences in physical function and pain when self-management interventions were compared to active interventions. The quality of the evidence was rated as low.

Conclusion

Reviewed studies suggest self-management interventions can be effective in improving physical function and reducing pain in the short and long-term for CWP including fibromyalgia. However, the quality of evidence was low. Future research should address quality issues whilst making greater use of theory and patient involvement to understand reported variability.
Physical activity and sedentary behaviour counselling: Attitudes and practices of mental health professionals
Authors: Shrestha Nipun , Pedisic Zeljko , Jurakic Danijel , Biddle Stuart J. H. , Parker Alexandra
Published: July 2021

Background

Despite recent interest in the mental health benefits of increasing physical activity (PA) and reducing sedentary behaviour (SB), little is known about PA and SB counselling provided by mental health professionals. Therefore, the aim of this study was to explore the attitudes and practices of mental health professionals in recommending more PA and less SB to their clients.

Methods

Quantitative data were collected using a modified version of the Exercise in Mental Illness Questionnaire in a sample of 17 Australian mental health professionals. The collected data were reported using percentages (for categorical data) and means and standard deviations (for numerical data). Additionally, in focus group discussions, 10 mental health professionals provided in-depth information about their clinical practice, facilitators, and perceived barriers in recommending more PA and less SB. They also provided suggestions on how to potentially improve their PA and SB counselling practices. The focus groups were audio-recorded, transcribed and analysed using thematic analysis.

Results

Only 35.3% of participants have undergone formal training in recommending PA in the treatment of mental illness. Most participants (64.7%) ranked PA counselling among the top three types of mental health treatment. All participants reported recommending PA to their clients at least “occasionally”, while 88% of them also provided SB counselling. However, the recommendations provided were usually not specific. The most commonly reported barriers for providing PA and SB counselling were a lack of knowledge and confidence. Participants also believed that, if they were more active themselves, they would be in a better position to recommend PA to their clients, by sharing their own experience of evidence-informed strategies designed to increase PA and reduce SB.

Conclusion

The findings of this study indicate that mental health professionals commonly provide generic PA and SB counselling to their clients. PA and SB counselling in the mental health setting could be improved by: including training on PA and SB counselling in formal education and continued professional training for mental health professionals; implementing interventions to increase PA and reduce SB among mental health professionals themselves; and ensuring support from an exercise or PA promotion specialist as a part of a multi-disciplinary approach to mental health care.
The relative age effect in young athletes: A countywide analysis of 9–14-year-old participants in all competitive sports
Authors: Gil Susana M. , Bidaurrazaga-Letona Iraia , Larruskain Jon , Esain Izaro , Irazusta Jon
Published: July 2021

The relative age effect (RAE) has primarily been investigated in male athletes involved in popular sports and high-level competitions. However, occurrence of RAE in other types of sports at the grassroots level, particularly in female athletes, is less well-studied. Thus, we examined the RAE in a large cohort of young athletes who participated in all competitive sports in Bizkaia, Spain, according to gender and specificity of the sport. The birth dates of 38,381 participants (65.1% males and 34.9% females) aged 9–14 years old in 37 competitive sports were analyzed. Birth dates were divided into four birth-quarters and compared to those of all children born in the same period using a χ2 goodness-of-fit test and standardized residuals. The effect size Cramer’s V was measured, and odds ratio and 95% confidence intervals were calculated to determine the odds of athletes born in January playing in the highest leagues. In the total sample, in boys RAE was evident in football, but only in higher-competition leagues (p<0.001, large effect size). In girls, RAE was evident in the most popular team sports: basketball (p<0.001, large effect size in basketball 1st league), handball and football (p<0.05, both small effect sizes). Players born in January were 3.23- and 2.89-times more likely to play in the 1st leagues than those born in December, for boys (football) and girls (basketball) respectively. In the overall analysis and in the remaining sports, presence of RAE was negligible. Therefore, the date of birth does not seem to be a constraint to participating in most sports in Bizkaia. The potential mechanisms for RAE are multifactorial and complex, yet a combination of factors, such as the popularity of a sport and the depth of competition, physicality and social influences may be involved. We discuss these mechanisms and potential measures to mitigate RAE.
Impact of social class on health: The mediating role of health self-management
Authors: Hu Xiaoyong , Wang Tiantian , Huang Duan , Wang Yanli , Li Qiong
Published: July 2021

Background

Studies have explored the relationship between social class and health for decades. However, the underlying mechanism between the two remains not fully understood. This study aimed to explore whether health self-management had a mediating role between social class and health under the framework of Socio-cultural Self Model.

Methods

663 adults, randomly sampled from six communities in Southwest China, completed the survey for this study. Social class was assessed using individuals’ income, education, occupation. Health self-management was assessed through evaluation of the health self-management behavior, health self-management cognition, health self-management environment. Physical health and mental health were measured by the Chinese version of Short-Form (36-item) Health Survey, which contains Physical Functioning, Role-Physical, Role-Emotional, Vitality, Mental Health, Social Function, Bodily Pain and General Health. Pearson’s correlation was used to examine the associations between major variables. Mediation analyses were performed to explore the mediating role of health self-management.

Results

Social class positively predicted self-rated health. The lower the social class, the lower the self-reported physical and mental health. Health self-management partially mediated the relationship between social class and self-rated health. That is, the health self-management ability of the lower class, such as access to healthy and nutritious food and evaluate their own health status, is worse than that of the higher class, which leads to physical and mental health inequality between the high and the low classes.

Conclusion

Health self-management mediated the relationship between social class and health. Promoting health self-management abilities are conducive to improving both physical and mental health.
Comparative use of CRISPR and RNAi to modulate integrin α3β1 in triple negative breast cancer cells reveals that some pro-invasive/pro-metastatic α3β1 functions are independent of global regulation of the transcriptome
Authors: Kenney James , Ndoye Abibatou , Lamar John M. , DiPersio C. Michael
Published: July 2021

Integrin receptors for the extracellular matrix play critical roles at all stages of carcinogenesis, including tumor growth, tumor progression and metastasis. The laminin-binding integrin α3β1 is expressed in all epithelial tissues where it has important roles in cell survival, migration, proliferation, and gene expression programs during normal and pathological tissue remodeling. α3β1 signaling and adhesion functions promote tumor growth and metastasis in a number of different types of cancer cells. Previously, we used RNA interference (RNAi) technology to suppress the expression of the ITGA3 gene (encoding the α3 subunit) in the triple-negative breast cancer cell line, MDA-MB-231, thereby generating variants of this line with reduced expression of integrin α3β1. This approach revealed that α3β1 promotes pro-tumorigenic functions such as cell invasion, lung metastasis, and gene regulation. In the current study, we used CRISPR technology to knock out the ITGA3 gene in MDA-MB-231 cells, thereby ablating expression of integrin α3β1 entirely. RNA-seq analysis revealed that while the global transcriptome was altered substantially by RNAi-mediated suppression of α3β1, it was largely unaffected following CRISPR-mediated ablation of α3β1. Moreover, restoring α3β1 to the latter cells through inducible expression of α3 cDNA failed to alter gene expression substantially, suggesting that use of CRISPR to abolish α3β1 led to a decoupling of the integrin from its ability to regulate the transcriptome. Interestingly, both cell invasion in vitro and metastatic colonization in vivo were reduced when α3β1 was abolished using CRISPR, as we observed previously using RNAi to suppress α3β1. Taken together, our results show that pro-invasive/pro-metastatic roles for α3β1 are not dependent on its ability to regulate the transcriptome. Moreover, our finding that use of RNAi versus CRISPR to target α3β1 produced distinct effects on gene expression underlines the importance of using multiple approaches to obtain a complete picture of an integrin’s functions in cancer cells.
Isolation and long-term expansion of murine epidermal stem-like cells
Authors: Wang Jingjing , Mongan Maureen , Zhang Xiang , Xia Ying
Published: July 2021

Epidermis is the most outer layer of the skin and a physical barrier protecting the internal tissues from mechanical and environmental insults. The basal keratinocytes, which, through proliferation and differentiation, supply diverse cell types for epidermal homeostasis and injury repair. Sustainable culture of murine keratinocyte, however, is a major obstacle. Here we developed murine keratinocyte lines using low-Ca2+(0.06 mM) keratinocyte serum-free medium (KSFM-Ca2+) without feeder cells. Cells derived in this condition could be subcultured for >70 passages. They displayed basal epithelial cell morphology and expressed keratin (Krt) 14, but lacked the epithelial-characteristic intercellular junctions. Moreover, these cells could be adapted to grow in the Defined-KSFM (DKSFM) media containing 0.15 mM Ca2+, and the adapted cells established tight- and adherens-junctions and exhibited increasedKrt1/10expression while retained subculture capacity. Global gene expression studies showed cells derived in KSFM-Ca2+media had enriched stem/proliferation markers and cells adapted in DKSFM media had epithelial progenitor signatures. Correspondingly, KSFM-Ca2+-derived cells exhibited a remarkable capacity of clonal expansion, whereas DKSFM-adapted cells could differentiate to suprabasal epithelial cell types in 3-dimentional (3D) organoids. The generation of stem-like murine keratinocyte lines and the conversion of these cells to epithelial progenitors capable of terminal differentiation provide the critically needed resources for skin research.
Different patterns of pneumothorax in patients with soft tissue tumors treated with pazopanib: A case series analysis
Authors: Aiba Hisaki , Kimura Hiroaki , Yamada Satoshi , Okamoto Hideki , Hayashi Katsuhiro , Miwa Shinji , Kawaguchi Yohei , Saito Shiro , Sakai Takao , Tatematsu Tsutomu , Nakanishi Ryoichi , Murakami Hideki
Published: July 2021

To investigate pneumothorax patterns in pazopanib treatment by focusing on the positional relationship between the visceral pleura and metastatic lung tumor, we examined 20 patients with advanced soft tissue tumors who developed lung metastases and underwent pazopanib treatment between 2012 and 2019. Pneumothorax was classified into two types based on the location of the metastatic lesion around the visceral pleural area before pazopanib treatment: subpleural type, within 5 mm from the pleura; and central type, >5 mm from the pleura. We investigated the rates of pneumothorax and the associated risk factors. Five patients experienced pneumothorax (three subpleural and two central types). Cavitation preceded pneumothorax in 83% of patients and led to connection of the cavitated cyst of the metastatic lesion to the chest cavity in the shorter term in patients with the subpleural type. Conversely, a more gradual increase in the cavity size and sudden cyst rupture were observed in the central type. The risk factors for pneumothorax were cavitation after initiating pazopanib and intervention before pazopanib, either ablation or surgery. The location of the metastatic lesions was not a risk factor for the occurrence of pneumothorax. In conclusion, pneumothorax is an adverse event associated with pazopanib treatment. Therefore, attention must be paid to predisposing factors such as the formation of cavitation after pazopanib initiation and previous interventions to the lungs. Moreover, because subpleural pneumothorax tends to occur earlier than the central type, a different time course can be anticipated based on the positional relationships of the metastatic lesions to the visceral pleura.
Do religious beliefs influence concerns for animal welfare? the role of religious orientation and ethical ideologies in attitudes toward animal protection amongst Muslim teachers and school staff in East Java, Indonesia
Authors: Pasaribu Dexon , Martens Pim , Takwin Bagus
Published: July 2021

There is ample research supporting White’s (1967) thesis, which postulates that religion and religious belief inhibit ecological concerns. This study thus seeks to explore the relationship between individuals’ acceptability for harming animals as one representation of ecological concern (measured using Animal Issue scale (AIS)) and their religious belief (measured using Religious Orientation Scale (ROS)) and ethical ideology (measured using Ethical Position Questionnaire (EPQ)). The study surveyed 929 Muslim teachers and school staff in East Java, Indonesia. We found that ROS correlates with EPQ whereby intrinsic personal (IP) relates with idealism while extrinsic social religious orientation (ES)—where religion is perceived as an instrument for social gain, membership and support—relates with relativism. However, using multiple regression analysis to examine both EPQ and ROS relation to acceptability for harming animals suggests mixed results. We found that, idealism and IP relate to a lower acceptability for harming animals, while relativism and ES correlate to a higher acceptability for harming animals. In another model where we calculate all the main variables with all the demographical and other determinants, we found that only ROS consistently relates to acceptability for harming animals. Additionally, we identify, explain and discuss significant demographic determinants along with this study’s limitations.
The Other Side of Me: Moving words into motion
Authors: Fish Laura , Pavey Liz
Published: July 2021

This article reflects upon the practice-led research project The Other Side of Me. It asks how to translate the life story of a young Aboriginal man born in Australia’s Northern Territory – adopted by an English family and raised in a remote hamlet in Cornwall, United Kingdom – into a narrative that engages with experiences of indigeneity in the contemporary world. At the project’s core is a collection of approximately 30 letters and poems that are crucially concerned with the trauma he suffered as a transracial adoptee – the conflicts of an individual coming to terms with two very different cultures. Telling his story raises issues of cultural appropriation. We propose here that adapting his story into dance offers one way to negotiate the challenges of cultural appropriation. Importantly, this process of adaptation is iterative, creating space for multiple voices and bodies to retell and reinterpret a story of personal trauma that sits at the limits of linguistic expression.
Non-infectious risk factors for intrapartum stillbirth in a swine farm in the North of Vietnam
Authors: Nam Nguyen Hoai , Sukon Peerapol
Published: July 2021

Background and Aim: Stillbirth causes considerable loss to the pig farming industry. Methods aimed at reducing stillbirth should base on the understanding of risk factors for intrapartum stillbirth because it accounts for 75% of all stillbirths. Unfortunately, few studies have differentiated between intrapartum and prepartum stillbirths leading to inadequate information about risk factors for sole intrapartum stillbirth. This study investigated risk factors for piglet's intrapartum stillbirth.

Materials and Methods: Data of 1527 piglets born from 103 sows in one herd were recorded. Generalized linear mixed models were used to determine the relationship between investigated risk factors and intrapartum stillbirth at the piglet level. The potential risk factors were parity, gestation length (GL), litter size (LS), birth order (BO), birth interval (BI), cumulative farrowing duration (CFD), gender, crown-rump length, birth weight (BW), body mass index, ponderal index (PI), and BW deviation.

Results: About 60% (60.2%, 62/103) litters had stillborn piglet(s), and the intrapartum stillbirth rate was 5.8% (89/1527). BW deviation (≤0.1 and >0.6 kg), LS >13, GL (<114 and >117 days), PI ≤54, and BO >10 were the most significant factors associated with increased intrapartum stillbirth. No effect of parity, sex, BI, and CFD on intrapartum stillbirth was detected.

Conclusion: These data stressed the importance of piglets' size and shape in the prediction of intrapartum stillbirth. Furthermore, large LS, high BO, short, and long GL were associated with increased intrapartum stillbirth. The results of this study suggest that procedures aimed at increasing litter homogeneity, optimizing piglets' size and shape, avoiding short and long gestation, and increasing supervision rate, especially at the second half, of the farrowing may reduce piglet's intrapartum stillbirth.
Thermal Performance Comparison of Parabolic Trough Collector (PTC) Using Various Nanofluids
Authors: Shirole Ashutosh , Wagh Mahesh , Kulkarni Vivek
Published: July 2021

The objective of this paper is to investigate the theoretical performance of Parabolic Trough Collector (PTC) using various nanofluids. The theoretical performances are calculated for Al2O3, graphite, magnetite, SWCNH, CuO, SiO2, MWCNT, TiO2, Fe2O3, and ZnO in water nanofluids. The heat transfer equations, thermodynamic properties of nanofluid and pumping power are utilised for the development of novel thermal model.  The theoretical thermal efficiency of the PTC is calculated, and the economic viability of the technology is predicted for a range of nanofluid concentration. The results showed that the thermal conductivity increases with the concentration of nanoparticles in the base fluid. Magnetite nanofluid showed the highest thermal efficiency, followed by CuO, MWCNT, ZnO, SWCNH, TiO2, Fe2O3, Al2O3, graphite, and SiO2, respectively. The study reveals that MWCNT at 0.4% concentration is the best-suited nanofluid considering thermal gain and pumping power. Most of the nanofluids achieved optimum efficiency at 0.4% concentration. The influence of mass flow rate on thermal efficiency is evaluated. When the mass flow rate increased from 70 Kg/hr to 90Kg/hr, a 10%-20% efficiency increase is observed. Dispersing nanofluids reduces the levelized cost of energy of large-scale power plants. These findings add to the knowledge of the scientific community aimed explicitly at solar thermal energy technology. The report can also be used as a base to pursue solar thermal projects on an economic basis.
Embodied Human Intersubjectivity: Imaginative Agency, To Share Meaning
Authors: Trevarthen Colwyn
Published: July 2021

Human beings move coherently as individual selves, body and mind adapted to perform complex activities with imagination, knowledge, and skill; perceiving the environment by engaging it with discrimination and care. Human beings live intersubjectively in communitiesl each with the rituals, beliefs, and language of a culture, along with a history of affective relationships and agreed habits for acting in cooperation. These attachments and cultural habits depend upon an ability to sense the intentions, interests, and feelings of other human selves through sympathetic response to motives and emotions as displayed in the shapes and rhythms of body movement: an ability that infants possess from birth. No brain theory explains this ‘felt immediacy’ of others’ life experience, which philosophers of the Scottish Enlightenment accepted as proof that human beings are ‘innately sympathetic’. An innate time sense, capacity to ‘attune’ to the dynamics of body movement, and ability to recognise serial ordering in ‘stories’ all appear essential. A theory of ‘communicative musicality’ employs key parameters of pulse, quality of movement, and narrative, applying them to poetry, music, dance, the prosody and rhetoric of language, and the regulation of skillful practices of all kinds. These elements - present in foetal movements and engaged in through joyful intersubjective ‘story-telling’ from birth - give direct information on how the human brain orchestrates reflex functions to move the body with sensations of grace and efficiency. Their age-related development leads to mastery of language and cultural rituals. They conduct all cognitive functions and all meaning making.
La Falange: The Structure of a Fascist Dream
Authors: Brandt Per Aage
Published: July 2021

The text proposes a structural narrative reading of José Antonio Primo de Rivera’s falangist discourse and shows how its thinking is based on spatial and dynamic imagination and a particularly strong sacrificial nationalist motif. It further suggests that the symbolic dimension in its nationalism constitutes a driving emotional force to be found in all nationalisms. Falangism was a religious version of fascism, famous for becoming the official ideology of Francoist Spain; but it shared with all militant national political forms of thinking the emotionally compelling mystique: the feeling of a spiritual essence and force emanating from a beloved land and conveying existential identity and value to its subjects, thus justifying and calling for committed violent and sacrificial acts that override ordinary systems of lawful behavior.
Evaluation of changes in cellulose micro/nanofibrils structure under chemical and enzymatic pre-treatments
Authors: Moulin Jordão Cabral , Durães Alisson Farley Soares , Dias Matheus Cordazzo , Silva Luiz Eduardo , de Amorim dos Santos Allan , Damásio Renato Augusto Pereira , Ugucioni Júlio César , Tonoli Gustavo Henrique Denzin
Published: July 2021

The objective of the present work was to evaluate the use of Raman microspectroscopy analysis to assess changes in cellulose micro/nanofibril structure from fibers subjected to different pre-treatments. Pulp fibers were pre-treated with 5 wt% NaOH for 2 h, 10 wt% NaOH for 1 h, and endoglucanase-type enzymes to improve nanofibrilation. After the pre-treatments, the fibers were mechanically fibrillated to produce cellulose micro/nanofibrils, which were made into films to be analyzed. Fibers pre-treated with 5 wt% NaOH produced 59% micro/nanofibrils with average diameter less than 30 nm, for Eucalyptus, and 46% of micro/nanofibrils, with the same diameter, for Pinus. However, the enzymatic pre-treatment was the most efficient, resulting in 83% of micro/nanofibrils for Eucalyptus and 78% for Pinus. This corroborates with the lowest values of the 1.096/2.896 ratio and degree of polymerization, indicating chain shortening in cellulose. X-ray diffraction and Raman microspectroscopy crystallinity results presented similar tendencies, with increased crystallinity caused by all pre-treatments, being 5 wt% NaOH for 2 h the highest, with 70%, for Eucalyptus and Pinus. Enzymatic pre-treatment has produced the best fibrillation and greater crystallinity. The present work has shown a reliable way of assessing cellulose structure using Raman microspectroscopy.
Size Effects and Beyond-Fourier Heat Conduction in Room-Temperature Experiments
Authors: Fehér Anna , Lukács Norbert , Somlai László , Fodor Tamás , Szücs Mátyás , Fülöp Tamás , Ván Peter , Kovács Róbert
Published: July 2021

It is a long-lasting task to understand heat conduction phenomena beyond Fourier. Besides the low-temperature experiments on extremely pure crystals, it has turned out recently that heterogeneous materials with macro-scale size can also show thermal effects that cannot be modeled by the Fourier equation. This is called over-diffusive propagation, different from low-temperature observations, and is found in numerous samples made from metal foam, rocks, and composites. The measured temperature history is indeed similar to what Fourier’s law predicts but the usual evaluation cannot provide reliable thermal parameters. This paper is a report on our experiments on several rock types, each type having multiple samples with different thicknesses. We show that size-dependent thermal behavior can occur for both Fourier and non-Fourier situations. Moreover, based on the present experimental data, we find an empirical relation between the Fourier and non-Fourier parameters, which may be helpful in later experiments to develop a more robust and reliable evaluation procedure.
Crystal structure of monocarbonyl(N-nitroso-N-oxido-phenylamine-κ
2
O,O′)(tricyclohexylphosphine-κP)rhodium(I), C25H39N2O3PRh
Authors: Alexander Orbett T. , Venter Johan
Published: July 2021

C25H39N2O3PRh, triclinic, P21/n (no. 14), a = 13.505(5) Å, b = 14.266(5) Å, c = 13.405(4) Å, β = 91.280(3)°, V = 2574.8(15) Å3, Z = 4, R

gt
(F) = 0.0399, wR

ref
(F
2) = 0.1026, T = 100 K.
The crystal structure of the co-crystal: 2-hydroxybenzoic acid – N′-(butan-2-ylidene)pyridine-4-carbohydrazide, C10H13N3O·C7H6O3
Authors: Setshedi Itumeleng B. , Smith Mark G.
Published: July 2021

C10H13N3O·C7H6O3, monoclinic, P21/n (no. 14), a = 7.4038(9) Å, b = 30.448(3) Å, c = 7.6744(8) Å, β = 112.013(3)°, V = 1603.9(3) Å3, Z = 4, R

gt
(F) = 0.0492, wR

ref
(F
2) = 0.1384, T = 173 K.
Photochromic dyes
Authors: Towns Andrew
Published: July 2021

This article describes the defining characteristics of photochromic dyes and highlights the subset of properties that are of greatest commercial importance. It outlines the history of the industrial exploitation of photochromic colorants before moving on to discuss current and potential applications. In doing so, a brief tour of key types of photochromic dye is provided.
Reproducibilidad de la escala de Masmali en la valoración de la película lagrimal
Authors: Daza Martínez Camilo Luis , Sánchez Fragozo Rafael Humberto , Márquez García Martha Lucila , Barrios Arlante Juan José
Published: July 2021

Objetivo: determinar la reproducibilidad inter evaluador de la escala de Masmali en función del Test de Ferning para la evaluación de la película lagrimal.Materiales y Métodos: se realizó un estudio observacional analítico de evaluación de pruebas diagnósticas. La muestra estuvo integrada por 50 estudiantes del programa de optometría de la Universidad Santo Tomás, Bucaramanga.  Se evaluó la osmolaridad de la película lagrimal de los individuos a través del test de Ferning.  Dos observadores clasificaron los patrones en helecho obtenidos, empleando la escala de Masmali para determinar su reproducibilidad.Resultados: se demostró que la escala de Masmali es una herramienta de medición de la osmolaridad lagrimal válida; sus resultados son confiables y reproducibles. La concordancia inter evaluador fue moderada con un Kappa Ponderado de 0,5658 con un 88% de acuerdo y un error estándar de kappa de 0,0995 y un valor P de <0,0001.Conclusiones: se recomienda el uso de la escala de Masmali como un método de evaluación del fluido lagrimal, por arrojar resultados confiables. No obstante, estos deben ser correlacionados con otras pruebas de superficie ocular para la emisión de diagnósticos en la evaluación de las disfunciones lagrimales.
The Role of Emotions in Mobilization of Society to Fight Climate Change: Constructing Emotional State to Inspire Mass Movement
Authors: Mataitytė Neringa
Published: July 2021

How do emotions contribute to mobilizing the international community to join massive protests against climate change? Although it is common to superficially state that protests are full of various emotions, it remains unclear how emotions become collective on the international level and how they ensure the spread of mass mobilization. This research paper examines the process of collectivization of emotions and how it explains mass mobilization in the case of international climate change strikes. This paper raises the question of how the emotional environment was favourably constructed in Greta Thunberg’s case in order to mobilize international society to join climate change strikes, and it aims to reveal how group emotions play an important role in successful international mobilization. Based on Sarah Ahmed’s theory of cultural politics of emotions and James M. Jasper’s theory linking emotions and social movements, it is assumed that specific emotions were circulated to create a distinct emotional environment that inspired the international community to join Thunberg’s climate strike. An Emotional Discourse Analysis revealed that Thunberg’s speeches are full of emotional potential that provokes reactive emotions such as fear, anger and hope in the global society and establishes an injustice-based framing of the problem as well as the dichotomy between the political elite and the global society. This study contributes to the research field of emotions in international relations by exploring in more depth the collectivization of emotions and expands the theory of cultural politics of emotions to include explanations of international politics phenomena such as mass mobilization.
Cost-Effectiveness of Nasal High Flow Versus CPAP for Newborn Infants in Special-Care Nurseries
Authors: Huang Li , Manley Brett J. , Arnolda Gaston R. B. , Owen Louise S. , Wright Ian M. R. , Foster Jann P. , Davis Peter G. , Buckmaster Adam G. , Dalziel Kim M.
Published: July 2021

BACKGROUND

Treating respiratory distress in newborns is expensive. We compared the cost-effectiveness of 2 common noninvasive therapies, nasal continuous positive airway pressure (CPAP) and nasal high-flow (nHF), for newborn infants cared for in nontertiary special care nurseries.

METHODS

The economic evaluation was planned alongside a randomized control trial conducted in 9 Australian special care nurseries. Costs were considered from a hospital perspective until infants were 12 months of age. A total of 754 infants with respiratory distress, born ≥31 weeks’ gestation and with birth weight ≥1200 g, <24 hours old, requiring noninvasive respiratory support and/or supplemental oxygen for >1 hour were recruited during 2015–2017. Inpatient costing records were obtained for 753 infants, of whom 676 were included in the per-protocol analysis. Two scenarios were considered: (1) CPAP versus nHF, with infants in the nHF group having “rescue” CPAP backup available (trial scenario); and (2) CPAP versus nHF, as sole primary support (hypothetical scenario). Effectiveness outcomes were rate of endotracheal intubation and transfer to a tertiary-level NICU.

RESULTS

As sole primary support, CPAP is more effective and on average cheaper, and thus is superior. However, nHF with back-up CPAP produced equivalent cost and effectiveness results, and there is no reason to make a decision between the 2 treatments on the basis of the cost or effectiveness outcomes.

CONCLUSIONS

Nontertiary special care nurseries choosing to use only 1 of the modes should choose CPAP. In units with both modes available, using nHF as first-line therapy may be acceptable if there is back-up CPAP.
Identificación de Fusarium en granos de frijol negro (Phaseolus vulgaris L.) en Costa Rica
Authors: Guido Mora Ana Zulay , Blanco Meneses Mónica , Granados Montero María del Milagro , Viñas Meneses María
Published: July 2021

Introducción. El frijol común (Phaseolus vulgaris L.) es una leguminosa consumida ampliamente en países en vías de desarrollo. En Costa Rica su consumo es alto (10,54 kg.persona-1.año-1) y su producción se localiza principalmente en regiones al sur y al norte del país. Los granos de esta leguminosa podrían estar contaminados con Fusarium, un hongo micotoxigénico que coloniza diferentes cultivos. Objetivo. Identificar las especies de Fusarium que colonizan los granos de frijol negro en Costa Rica. Materiales y métodos. Se recolectaron 49 muestras de granos de frijol negro durante 2017, 2018 y 2019 en regiones donde se produce este grano en Costa Rica. Estas se utilizaron para aislar e identificar las especies de Fusarium basado en secuencias parciales de los genes TEF1α (factor de elongación de la traducción 1-alfa) y RPB2 (subunidad de la ARN polimerasa II). Resultados. Se obtuvieron 28 aislamientos de Fusarium, de los cuales 82% pertenecen al com[1]plejo de especies Fusarium incarnatum-equiseti (FIESC). La presencia de especies de Fusarium varió según el año de recolección; en el 2018 se encontró la menor prevalencia (43%) y el 2019 la mayor (76%). El 71% de las especies de Fusarium se aislaron de muestras recolectadas en la región sur del país. F. equisetti se aisló solo de una muestra procedente de la región Atlántica, mientras que F. incarnatum, F. oxysporum y F. verticillioides se encontraron distribuidos en muestras colectadas en diferentes regiones del país. Conclusión. El presente estudio demostró la diversidad de especies de Fusarium que colonizan los granos de frijol negro en Costa Rica según la ubicación geográfica y el año de recolección de la muestra. La mayoría de las especies aisladas resultaron productoras de micotoxinas que causan efectos adversos en la salud humana.