bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardioprotective Effects of Sodium-Glucose Cotransporter 2 Inhibitors and Their Possible Association With Normalization of the Circadian Index of Heart Rhythm
Authors: Dogan Nazile Bilgin , Yasar Hamiyet Yilmaz , Kilicaslan Baris
Published: December 2023

Background

Updated recommendations for the treatment of heart failure with reduced ejection fraction (HFrEF) include sodium-glucose cotransporter 2 (SGLT2) inhibitors and other long-established HFrEF therapies. These drugs’ mechanisms of action have yet to be fully clarified.

Objective

This study evaluated the effects of SGLT2 inhibitors on the modulation of autonomic function at 1 month beyond conventional HF therapy.

Methods

This single-center, observational, prospective study was conducted from January 2020 to December 2022. Patients with type 2 diabetes who had ischemic HFrEF and met the study criteria were considered for SGLT2 inhibitor treatment with empagliflozin or dapagliflozin. Changes in the circadian index were used as the primary outcome to assess the early effects of SGLT2 inhibitors on autonomic function. Changes in functional effort capacity and laboratory findings were also evaluated. Participants’ circadian index was measured by a 24-hour rhythm Holter monitoring recorder (BTL-08 Holter H100). A symptom-limited treadmill test assessed patients’ effort capacities. Tests were repeated after 1 month of therapy.

Results

The mean (SD) age of the 151 participants was 56.95 (7.29) years; their mean (SD) left ventricular EF was 35.69% (7.10%), and 95 participants were men (62.9%). From baseline to 1 month, mean (SD) daytime heart rate (80.63 [9.17] vs 77.67 [8.04] beats per minute; P = .004) and nighttime heart rate (76.83 [11.34] vs 73.81 [10.25] beats per minute; P = .03) decreased significantly. Variation in the circadian indexes (mean [SD], 1.04 [0.02] vs 1.10 [0.04]; P < .001) was statistically significant, favoring increased modulation of autonomic function. The increases in exercise duration (mean [SD], 8.88 [3.69] minutes and median [IQR], 8.81 [5.76-12.13] minutes vs 9.72 [3.14] and 9.59 [7.24-12.22] minutes; P = .04) and exercise capacity (mean [SD], 203.38 [65.18] m and median [IQR], 119.22 [149.43-259.15] m vs 335.61 [51.39] and 325.79 [293.59-376.91] m; P < .001] were also significant.

Conclusion

The use of SGLT2 inhibitors during early treatment can favorably affect both autonomic dysfunction and functional effort capacity of patients with type 2 diabetes with ischemic HFrEF.
Normative becoming in the digital sphere: WhatsApp parents’ groups in Chilean education
Authors: Moyano Dávila Camila , Tabilo Ismael , Vera-Muñoz María Isabel , Alarcón Arcos Samanta
Published: December 2023

Digital communicational technologies, such as WhatsApp, have been part of schools both before and during the pandemic. This article explores the normative emergence of being a student, a parent, and a teacher in the use of parents’ WhatsApp groups. In Chile, this digital application is widely used by the population, and it is particularly important for school communities. Based on interviews conducted with teachers and parents, and a theoretical approach based on science and technology studies, the results show that students are constantly labeled as “good” or “bad” without nuance, which produces stereotypes, and parents are also labeled in a binary way, with one group of alarmists and one of relaxed parents, where counter criticisms emerge, while teachers are seen as an extension of the schools and are expected to be constantly present. Digital communication technologies mediate these interactions and open up a new level of interaction, with standards and meanings enabled by the features of the application. We discuss these results, emphasizing that the normativities of these becomings are intertwined in the digital sphere, and using a mapping visualization of the analysis, we show how normativity acts ubiquitously and produces constantly changing expectations of how one should be for those in the group. The mapping exercise shows that the main relationship between the three becomings is emotion, so we conclude that, on the understanding that affect exceeds individuality and represents intensities online, normativities are also incorporated as affective responses in the parents’ WhatsApp group.
SAĞLIK KURULUŞLARINDA ETKİLEŞİM KALİTESİNİN HASTA MEMNUNİYETİNE VE SADAKATİNE ETKİSİ
Authors: BİLGİN Yusuf , TURKAY ABA Aysun
Published: December 2023

Bu araştırmanın amacı, sağlık kuruluşlarında etkileşim kalitesinin hasta memnuniyeti ve hasta sadakati üzerindeki etkisini incelemektir. Ayrıca araştırmada sağlık kuruluşlarında hasta memnuniyetinin hasta sadakati üzerindeki etkisinin analiz edilmesi amaçlanmaktadır. Araştırmada sağlık kuruluşunda hizmet kalitesini ölçmek için Brady ve Cronin (2001) tarafından önerilen çok boyutlu ölçüm modeli kullanılmıştır. Bu doğrultuda, sağlık kuruluşunda etkileşim kalitesinin bileşenleri; tutum, davranış ve uzmanlık olarak tanımlanmıştır. Araştırmanın evrenini, Kayseri Şehir Hastanesinde ayakta ve yataklı tedavi gören hastalar oluşturmaktadır. Araştırma verileri, kolayda örnekleme yöntemi kullanılarak 391 hastadan toplanmıştır. Elde edilen veriler Yapısal Eşitlik Modellemesi (AMOS) kullanılarak analiz edilmiştir. Analiz sonucunda, sağlık kuruluşlarında etkileşim kalitesinin hasta memnuniyeti ve hasta sadakatini anlamlı bir şekilde etkilediği tespit edilmiştir. Öte yandan, analiz sonuçları sağlık kuruluşlarında hasta memnuniyetinin hasta sadakati üzerinde anlamlı bir etkiye sahip olmadığını göstermektedir. Buna ek olarak, uzmanlığın sağlık kuruluşlarında hasta memnuniyeti ve sadakati üzerinde en etkili etkileşim kalitesi bileşeni olduğu belirlenmiştir. Davranış bileşeni ise uzmanlığa göre hasta memnuniyeti ve sadakati üzerinde daha düşük düzeyde bir etki meydana getirmektedir. Bunların aksine etkileşim kalitesi bileşenlerinden tutum, hasta memnuniyeti ve hasta sadakati üzerinde anlamlı bir etkiye sahip değildir.
SUPPORT VECTOR REGRESSION (SVR) METHOD FOR PADDY GROWTH PHASE MODELING USING SENTINEL-1 IMAGE DATA
Authors: Muradi Hengki , Saefuddin Asep , Sumertajaya I Made , Soleh Agus Mohamad , Domiri Dede Dirgahayu
Published: December 2023

Support Vector Machines (SVMs) have received extensive attention over the last decade because it is claimed to be able to produce models that are accurate and have good predictions in various situations. This study aims to test the SVR (Support Vector Regression) method for modeling the growth phase of paddy using sentinel-1 image data. This method was compared for its accuracy with the LR (Linear Model) method using RMSE and R2 statistics and model stability using 10 repetitions. The accuracy of the model with the two best predictors is when the NDPI and API Polarization Index are the predictors. The paddy age model from the SVR method is better than the paddy age model from the LR method, where the SVR method produces a model with an average RMSE of 11.13 and an average coefficient of determination of 88.10%. The accuracy of the SVR model with NDPI and API predictors can be improved by adding VH polarization to the model, where the average RMSE statistic decreases to 11.0 and the average coefficient of determination becomes 88.42%. In this scenario, the best model gives a minimum RMSE value of 10.35 and a coefficient of determination of 90.05%.
GEOGRAPHICALLY WEIGHTED PANEL LOGISTIC REGRESSION SEMIPARAMETRIC MODELING ON POVERTY PROBLEM
Authors: Azizah Aliyah Husnun , Nurjannah Nurjannah , Fernandes Adji Achmad Rinaldo , Hamdan Rosita
Published: December 2023

Regression analysis is a statistical method used to investigate and model the relationship between variables. Furthermore, a regression analysis was developed that involved spatial aspects, namely Geographically Weighted Regression (GWR). GWR modeling consists of various types, one of which is Geographically Weighted Logistic Regression Semiparametric (GWLRS), an extension of the Logistic GWR model that produces local and global parameter estimators. In this study, it is proposed to combine the GWLRS model using panel data or Geographically Weighted Panel Logistic Regression Semiparametric (GWPLRS). The case study used in this research is the problem of poverty in 38 regions/cities in East Java, Indonesia, in 2018 – 2022 as seen from the Poverty Gap Index. The weights used in this research are the adaptive gaussian kernel weighting functions. The results of the parameter significance test show that the Human Development Index as global variable has a significant effect on each region/city.
SURVIVAL ANALYSIS FOR RECURRENT EVENT DATA USING COUNTING PROCESS APPROACH: APPLICATION TO DIABETICS
Authors: Wuryandari Triastuti , Wilandari Yuciana
Published: December 2023

Survival analysis is a branch of statistics for analyzing the duration of time until one or more events occur. Time to recurrence of diabetics including survival data. Diabetes can’t be cured but it can be controlled. Diabetics who don’t maintain their health and lifestyle will experience recurrence. Factors thought to influence the recurrence of diabetics are internal factors such as genetics and external factors such as lifestyle. The recurrence time of an object includes recurrent events because each object can experience the same recurrent event during the follow-up. One of the analysis to determine factors that are thought to influence the recurrence time of diabetics is survival analysis. Survival data can be modeled into a regression model if the survival time of an object is influenced by other factors. One of the regression models for survival data is Cox regression. One of the Cox regression models for recurrent event data is the AG model which uses a counting process approach. This study used data on the recurrence of diabetics at MH Thamrin Cileungsi Hospital. Based on data analysis, factors that influence the recurrence of diabetics are age, gender, and type of complication.
Życie seksualne w Chińskiej Republice Ludowej - historia i współczesność
Authors: Strzemkowska Natalia
Published: December 2023

Obecna polityczna i gospodarcza pozycja Chińskiej Republiki Ludowej powoduje, że warto przyjrzeć się wolności seksualnej Chińczyków. Model zachowań seksualnych zależy bardzo mocno od współczesnego zachwiania demograficznego Państwa Środka, zatem rzeczą istotną wydaje się być omówienie tej problematyki. Niniejszy artykuł analizuje historię rewolucji seksualnej, jej konsekwencje, a także podejmuje próbę przedstawienia wartości i norm, które w sposób bezpośredni wpływają na współczesne problemy społeczne związane z dostępem do edukacji seksualnej i przestrzeganiem praw osób homoseksualnych w Chińskiej Republice Ludowej.
Is Decoloniality a New Turn in Postcolonialism?
Authors: Gu Ming Dong
Published: December 2023

A new orientation appeared in cultural studies at the turn of the twenty-first century. As it centers around the concept, “decoloniality,” it has been called the “decolonial turn” by some scholars. Since the decolonial turn addresses “decoloniality,” one would think it signals a new orientation in postcolonial studies. Proponents of “decoloniality,” however, have denied it as a concept of postcolonialism and even regretted its conflation with postcolonialism and decolonization. This article critically examines major ideas in the decoloniality program in relation to issues of postcolonialism and argues for its placement in the context of postcolonialism so as to enrich postcolonial studies and advance the project of decoloniality.
ECG Beat classification: Impact of linear dependent samples
Authors: Hintermüller Christoph , Hirnschrodt Michael , Blessberger Hermann , Steinwender Clemens
Published: December 2023

The Electro Cardio Gram (ECG) is a very valuable clinical tool to access the electric function of the heart. It provides insight into the different phases of the heart beat and various kinds of disorders which may affect them. In literature the impact of linear dependency between feature signals upon the classification outcome and how to reduce it have been largely investigated and discussed. This study puts a focus upon linear dependency between samples of imbalanced data sets, its relation to the observed over fitting with respect to majority classes and hot to reduce it. A set of 58 feature signals is used to train a several LDA classifier either discriminating 3 classes (Normal, Artefact, Arrhythmic) or 5 Classes (Normal, Artefact, Atrial and ventricular premature contractions and bundle branch blocks). The training data set is preprocessed using four sample reduction approaches and a nearest neighbour clustering method. In the case of 5 classes accuracies of 96.82% in the imbalanced case and 97.44% for the data preprocessed with the QR or SVD methods were obtained. For 3 classes curacies of 97.68% and 98.12% were achieved. With the nearest neighbour clustering method only accuracies of 96.00% for 5 classes and 97.37% for 3 classes could be achieved. The results clearly show that imbalanced ECG data does contain linear dependent samples. These cause a bias towards majority class which will be over fitted by the classifier. Sample reduction methods and algorithms which are not aware of the presence linear dependent samples like the nearest neighbour clustering approach even further increase this bias ore even worse destroy relevant information by merging samples which encode distinct aspects of the beat class, destroying relevant information.
Advancements in Adult and Neonatal Breathing Simulation Using the xPULMTM Electro-mechanical Lung Simulator
Authors: Vodenicharov Vasil , Pasteka Richard
Published: December 2023

Simulation is essential for healthcare professionals, students, and researchers, providing a safe environment for skill development and improved patient care. This paper presents enhancements to the xPULMTMelectro-mechanical lung simulator, enabling simulation of adult and neonatal breathing patterns. Hardware improvements include interchangeable flow sensors and additional temperature, humidity, volatile organic compounds (VOCs), and pressure sensors. The software redesign separates control and processing elements, enhancing performance. Measured parameters demonstrate expanded capabilities, such as increased airflow range and higher sampling frequency. Airtightness measurements show improved chamber sealing. Future developments aim to simulate neonatal breathing patterns and optimise software for high-frequency measurements. The enhanced xPULMTM simulator provides a realistic platform for simulating lung mechanics, benefiting respiratory medicine research and education.
Conceptualizing Corpus-Based Genre Pedagogy as Usage-Inspired Second Language Instruction
Authors: Wang Yuanheng (Arthur) , Lu Xiaofei
Published: December 2023

Corpus-based genre pedagogy (CBGP), the instructional integration of discourse-based rhetorical analysis and corpus-based linguistic analysis of diverse genres, has gained attention from English for Academic Purposes (EAP) researchers and practitioners aiming to cultivate the academic writing skills of second language (L2) learners. This has led to a need for the continuous conceptualization of CBGP (Lu, Xiaofei, J. Casal Elliott, and Yingying Liu. 2021. “Towards the Synergy of Genre- and Corpus-Based Approaches to Academic Writing Research and Pedagogy.” International Journal of Computer-Assisted Language Learning and Teaching 11 (1): 59–71). Additionally, usage-based approaches to L2 acquisition (U-SLA), a collection of cognitive and potentially sociocognitive theoretical approaches to language and language acquisition (Ellis, Nick C., Ute Römer, and Matthew Brook O’Donnell. 2016. Usage-Based Approaches to Language Acquisition and Processing: Cognitive and Corpus Investigations. Malden: Wiley-Blackwell; Wulff, Stepanie, and Nick C. Ellis. 2018. “Usage-Based Approaches to Second Language Acquisition.” In Bilingual Cognition and Language: The State of the Science across its Subfields, edited by D. Miller, F. Bayram, J. Rothman, and L. Serratrice, 37–56. Amsterdam: John Benjamins Publishing Company), have called for more pedagogically oriented research informed by usage-based principles (e.g., Tyler, Andrea E., Hae In Park, Mariko Uno, and Lourdes Ortega, eds. 2018. Usage-inspired L2 Instruction: Researched Pedagogy. Amsterdam: John Benjamins Publishing Company). Responding to such calls, we argue for conceptualizing CBGP as usage-inspired instruction given its intersections with key U-SLA instructional tenets. We first systematically review empirical studies on CBGP. Then, we introduce relevant U-SLA instructional tenets and interpret the CBGP studies to illuminate the extent to which CBGP resonates with different aspects of the U-SLA tenets. Eventually, we argue that CBGP can potentially unify the “social” and the “cognitive” in U-SLA’s accounts of L2 teaching and learning, making it a feasible way to materialize usage-inspired L2 instruction in actual classroom practice. Finally, we discuss future research and practical directions.
The Effect of Market and Technological Turbulence on Innovation Performance in Nascent Enterprises: The Moderating Role of Entrepreneur’s Courage
Authors: Namal Mete Kaan , Tufan Cenk , Köksal Kemal , Mert İbrahim Sani
Published: December 2023

Adapting to market and technological turbulence is essential for survival in a developing enterprise and requires making changes. Firms may need to increase their innovation performance to keep up and struggle with these changes to gain a competitive advantage. We believe that the courage of the entrepreneur emerges as a catalyst in such a struggle. Since a firm’s superior performance is contingent on both internal and external environments of the firm, depending on, contingency theory, the current study investigates the effect of market and technological changes, which are part of environmental changes, on innovation performance in nascent enterprises and the moderating role of courage in this effect. The authors collected data from 331 innovative companies acting in free trade zones by using the convenience sampling method via HR department managers. The results showed that market and technological changes were significantly and positively related to innovative performance, and the entrepreneur’s courage moderated this relationship. It can be stated that entrepreneurs with high courage responded to changes with more innovation than those with low courage.
Concerning the Nakayama property of a module
Authors: Karimzadeh Somayeh , Rostami Esmaeil , Hadjirezaei Somayeh
Published: December 2023

In this paper, we thoroughly study the Nakayama property and some related concepts.
Also, we describe multiplication modules that, among other things, satisfy the Nakayama property.
Next, we show that a ring 𝑅 is a Max ring if and only if all modules that can be generated by a finite or countable set have the weak Nakayama property.
We prove that a ring 𝑅 is a perfect ring if and only if every module that can be generated by a finite or countable set has the Nakayama property.
Finally, we present some categorical results on the aforementioned properties.
The Dirichlet problem in an infinite layer for a system of differential equations with shifts
Authors: Nytrebych Zinovii , Shevchuk Roman , Savka Ivan
Published: December 2023

In this paper, we study the problem with data on the boundary of the infinite layer

{

(
t
,
x
)

:

t
∈

(
0
,
h
)

,

x
∈

R
s

}

,
h

>
0

,

s
∈
N

,

\{(t,x):t\in(0,h),\,x\in\mathbb{R}^{s}\},\quad h>0,\,s\in\mathbb{N},

for the system of two differential equations of the second order in the time variable 𝑡 with shifts in the spatial variables

x
1

,

x
2

,
…
,

x
s

x_{1},x_{2},\ldots,x_{s}

.
We propose a differential-symbol method of constructing a solution of the problem and identify a class of vector functions in which the obtained solution is unique.
The method of solving the Dirichlet problem in the layer is illustrated by examples.
Accessing forbidden phases
Authors: Xing Yue , Li Zheng , Hou Huai Yu , Liu Ying , Wang Jing Tao
Published: December 2023

Thanks to the development of quantum mechanics-based crystal structure prediction methods in the past decade, numerous new compounds with low temperature thermodynamic stability, mainly binary intermetallic compounds, have been predicted. Differing from conventional alloy materials, the synthesis of these low temperature stable compounds may be impossible relying on traditional thermal activation methods since thermally activated atomic diffusion at low temperatures is so slow that phase formation may require cosmic-scale time. Strikingly, it has been shown that some special experimental methods can successfully synthesize low temperature stable compounds by introducing a large number of vacancies and defects into the material to enable atomic rearrangement and simultaneously increasing the phase transformation driving force to accelerate the reaction kinetics. This review summarizes the predictions of compounds that have not been experimentally reported to be stable at low temperatures and provides some experimental approaches that can be used for future synthesis. We describe the basic thermodynamics and kinetics of phase formation, show how compound formation is constrained at low temperatures, and illustrate that the formation of some compounds is nearly impossible without enhanced kinetics.
Online gaming and language aggression in a Tunisian Arabic context
Authors: Boukhris Khouloud
Published: December 2023

This paper intends to examine the development of conflictual interactions, how they might be resolved, and the socio-cultural norms involved, by adopting an analytical framework in an online gaming context. The current paper was inspired by Kádár and Haugh’s framework as it enables me to investigate both the macro and micro aspects of (im)politeness. The study’s aim is to further examine how impoliteness, language aggression and conflict are realised in two online gaming platforms, namely Fortnite and PUBG Mobile. Thus, I will explore discursively how these phenomena are subjective in a Tunisian Arabic setting and discuss how participants reach their subjective perception of conflict in ways that do not always correspond to the supposed intentions of the ostensible offender. The results indicate that conflict is subjective as it is evaluated in different ways by different gamers and could be a result of a conflictual intention. The findings also reveal that conflict may also be created/ escalated as a result of a non-conflictual intention. Thus, this paper contributes to understanding of conflict, how impoliteness can lead to conflict and the various aspects of impoliteness/the perception of impoliteness.
LLOD schema for Simplified Offensive Language Taxonomy in multilingual detection and applications
Authors: Lewandowska-Tomaszczyk Barbara , Bączkowska Anna , Dontcheva-Navrátilová Olga , Liebeskind Chaya , Valūnaitė Oleškevičienė Giedrė , Žitnik Slavko , Trojszczak Marcin , Povolná Renata , Selmistraitis Linas , Utka Andrius , Gudelis Dangis
Published: December 2023

The goal of the paper is to present a Simplified Offensive Language (SOL) Taxonomy, its application and testing in the Second Annotation Campaign conducted between March-May 2023 on four languages: English, Czech, Lithuanian, and Polish to be verified and located in LLOD. Making reference to the previous Offensive Language taxonomic models proposed mostly by the same COST Action Nexus Linguarum WG 4.1.1 team, the number and variety of the categories underwent the definitional revision, and the present typology was tested in the annotation on the publicly available offensive language datasets of each of the four languages. The results of the annotation are presented and as they are contained within the accepted statistical values on the inter-annotator agreement in the SOL categories and their aspects, we propose this taxonomy as a core ontology which represents the encoding of the supported offensive languages and justify its use on new data in terms of a more universal Linguistic Linked Open Data (LLOD) schema.
Implicit offensiveness from linguistic and computational perspectives: A study of irony and sarcasm
Authors: Bączkowska Anna
Published: December 2023

The aim of this paper is to shed some light on the linguistic concept of implicit offensiveness. On the one hand, implicitness will be juxtaposed with indirectness as the two concepts are not conceived of here as synonymous. On the other hand, a typology of offensiveness (vs offensive language and vs offendedness) will be proposed, as well as the overarching term ‘covert meaning’ that will span figurative implicitness and non-figurative implicitness. The gradability of various forms of covert meaning and its overlap with overt meaning (subsuming explicit literal meaning and implicit literal meaning) will also be discussed. In the analysis, two sample implicit concepts will be examined (irony vs sarcasm) based on corpus data (of general English and dedicated offensiveness corpus) and using non-contextual embeddings. Theory-wise, the paper demonstrates that implicitness is a complex term which is fuzzy and gradable; methodology-wise, it shows how computational tools can be used to attest theoretical assumptions related to offensive covert terms.
Asymmetric kernel method in the study of strong stability of the PH/M/1 queuing system
Authors: Djabali Yasmina , Hakmi Sedda , Zougab Nabil , Aïssani Djamil
Published: December 2023

This paper proposes the nonparametric asymmetric kernel method in the study of strong stability of the PH/M/1 queuing system, after perturbation of arrival distribution to evaluate the proximity of the complex GI/M/1 system, where GI is a unknown general distribution.
The class of generalized gamma (GG) kernels is considered because of its several interesting properties and flexibility.
A simulation for several models illustrates the performance of the GG asymmetric kernel estimators in the study of strong stability of the PH/M/1, by computing the variation distance and the stability error.
Second annual report from the ISSPP PIPAC database
Authors: Mortensen Michael Bau , Casella Francesco , Düzgün Özgül , Glehen Olivier , Hewett Peter , Hübner Martin , Jørgensen Magnus Skov , Königsrainer Alfred , Marin Miguel , Pocard Marc , Rezniczek Günther , So Jimmy , Fristrup Claus Wilki
Published: December 2023

Objectives

To monitor the results of PIPAC directed therapy based on data from the International Society for the Study of the Pleura and Peritoneum (ISSPP) PIPAC database.

Methods

Analysis of data from patients entered between June 15th, 2020, and February 28th, 2023.

Results

Twelve centers reported 2,456 PIPAC procedures in 809 patients (median 2, range 1–18) with peritoneal metastasis (PM) from different primary tumors. Approximately 90 % had systemic chemotherapy prior to PIPAC. Twenty-eight percent were treated in prospective protocols. Overall non-access rate was 3.5 %. Concomitant surgical procedures were performed during PIPAC in 1.6 % of the patients. Median length of stay was 2 days. A total of 95 surgical complications were recorded, but only 22 % of these were graded ≥3b. Seventeen-hundred-and-three adverse events were noted, and 8 % were classified ≥3. The rate of complete or major histological response (peritoneal regression grade score, PRGS≤2) increased between the first and the third PIPAC in the group of patients who were evaluated by PRGS, and a PRGS ≤2 or a reduction of the mean PRGS of at least 1 between first and third PIPAC were observed in 80 %. Disease progression (50 %) or technical issues (19 %) were the most important reasons for stopping PIPAC treatment. Median overall survival from first PIPAC directed treatment varied from 10.7 months (CI 8.7–12.5) in gastric cancer to 27.1 months (16.4–50.5) in mesothelioma.

Conclusions

The ISSPP PIPAC database provides substantial real-world data supporting the use of PIPAC directed therapy in patients with PM from different primary tumors.
Werkstattbericht: Entwicklung und Evaluation eines neuen Tools für die seelsorgliche Dokumentation
Authors: Mösli Pascal , Aebi Renata
Published: December 2023

As part of the research project "Documentation of clinical pastoral care in the horizon of interprofessional spiritual care" of the Swiss National Science Foundation, a documentation tool was developed in the palliative care department of the Cantonal Hospital of Graubünden, which is intended to improve interprofessional cooperation between pastoral care and health professionals for the benefit of good patient care. The article describes the development process and the conceptual basis for the documentation tool and discusses it in the context of international developments. The tool is presented and the article concludes with reflections on the perspective of chaplaincy documentation practice.
Enzymatic comparison and expression pattern of pig B4GALNT2 and B4GALNT2-like proteins
Authors: Zhang Anjing , Zhong Zhining , Pan Dengke , Yang Peidong , Yang Shuqi , Ma Jideng , Luo Tingting , Chen Li , Zhang Jinwei , Sun Jing , Du Jiaxiang , Long Keren , Li Mingzhou , Lu Lu
Published: December 2023

Objectives

The final step in the production of the human Sd(a) antigen is catalyzed by beta-1,4-N-acetyl-galactosamine transferase 2 (B4GALNT2). This is done by adding a N-acetylgalactosamine residue via a beta-1,4 linkage to a subterminal galactose residue that has been substituted with an alpha-2,3-linked sialic acid. The final stage of the production of the Cad antigen is also catalyzed by B4GALNT2. Knocking out pig B4GALNT2 gene decreased human serum antibodies binding to pig cells, which greatly reduces the immunological rejection in clinical xenotransplantation trials. Interestingly, gene region LOC110255214 (hereafter named B4GALNT2-like) showed high similarity with the B4GALNT2 gene in the pig genome in our previous work, but whether B4GALNT2-like shares similar biological properties like B4GALNT2 remains to be elucidated, whether B4GALNT2-like is a potential immune gene in xenotransplantation remains to be determined.

Methods

In this study, we compared the tissue expression pattern of B4GALNT2-like and B4GALNT2 in Bama pigs.

Results

We found the expression of B4GALNT2-like was significantly higher in the duodenum, but lower in the heart, spleen, lung, kidney, comparing to B4GALNT2. Applied the Escherichia coli recombinant expression, we obtained 768 and 1,300 μg protein for B4GALNT2 and B4GALNT2-like from 1 L culture, respectively. Using the expressed recombinant proteins, the enzymatic activity of the two proteins was determined and compared.

Conclusions

The enzymatic assay showed that B4GALNT2-like has comparable catalytic activity with B4GALNT2 (58.7 % of B4GALNT2), addressing an important question whether B4GALNT2-like is a new immunological rejection gene.
The origins of saddles and riding technology in East Asia: discoveries from the Mongolian Altai
Authors: Bayarsaikhan Jamsranjav , Turbat Tsagaan , Bayandelger Chinbold , Tuvshinjargal Tumurbaatar , Wang Juan , Chechushkov Igor , Uetsuki Manabu , Isahaya Naoto , Hudson Mark , Shiraishi Noriyuki , Li Yue , Zhang Chengrui , Eregzen Gelegdorj , Caspari Gino , López-Calle Paula , Conver Joshua L. , Tressières Gaëtan , Chauvey Lorelei , Birgel Julie , Erdene-Ochir Nasan-Ochir , Bemmann Jan , Hodgins Gregory , Richter Kristine K. , Orlando Ludovic , Warinner Christina , Taylor William Timothy Treal
Published: December 2023

Innovations in horse equipment during the early Middle Ages provided advantages to societies from the steppes, reshaping the social landscape of Eurasia. Comparatively little is known about the precise origin of these crucial advances, although the available evidence points to early adoption in East Asia. The authors present new archaeological discoveries from western and northern Mongolia, dating to the fourth and fifth centuries AD, including a wooden frame saddle with horse hide components from Urd Ulaan Uneet and an iron stirrup from Khukh Nuur. Together, these finds suggest that Mongolian groups were early adopters of stirrups and saddles, facilitating the expansion of nomadic hegemony across Eurasia and shaping the conduct of medieval mounted warfare.
Dvě desetiletí na cestě k realizaci pomníku padlých v Jilemnici
Authors: Krčmář Miloš
Published: December 2023

The study contemplates the creation of war monuments commemorating the victims of the Great War in Czechoslovakia by analyzing the 20-year preparation and implementation of the monument in Jilemnice in North Bohemia. It also captures the fate of the monument during the Nazi occupation an d in the second half of the 1940s after the liberation of Czechoslovakia. Through a detailed study of archival documents, two periods of efforts to establish the monument are reconstructed. The ideological tone of the monument is also evaluated as well as t he individual contribution of the architect Blahomír Podpěra, the author of the monument.
Ghosts of Cho
Authors: Wanzo Rebecca
Published: December 2023

Nearly thirty years ago, Margaret Cho broke new ground as the star of ABC’s All-American Girl, the first network sitcom to have a predominantly Asian American cast. Cho’s series proved controversial, however, in its assimilationist politics and performance of negative ethnic stereotypes, and was canceled after only one year. In this article, FQ columnist Rebecca Wanzo traces the genealogy of Asian American sitcoms from All-American Girl to more recent productions such as Fresh Off the Boat, American Born Chinese, and PEN15. Interrogating the complex negotiations with race and representation in these series, the column concludes that the performance of abjection in Asian American comedy remains vexed.
The Rights of Transnational Corporations under International Humanitarian Law
Authors: Karska Elżbieta , Czepek Vita
Published: December 2023

For several decades, transnational (multinational) corporations have been considered significant actors in international relations. It is also an undeniable fact that transnational corporations are economically stronger than many states. They are also increasingly present in situations of armed conflict. On one hand, companies operating in unstable environments are exposed to the violence and consequences of armed conflicts. On the other hand, some of their actions during armed conflicts may lead to violations, particularly of international human rights law. In this paper, however, the authors would like to focus more on the status of the protection of transnational corporations under international humanitarian law. It is possible to put forward the thesis that transnational corporations, having met certain requirements, can enjoy protection under international humanitarian law. Verification of this research thesis requires analysis of issues such as the relationship between international human rights law and international humanitarian law. It also requires the analysis of the legal basis on which the rights of transnational corporations may be founded and their scope.
The Principle of Equal Treatment in the Google Shopping Case
Authors: Pais Sofia Oliveira , Domingos Marta Prata
Published: December 2023

This article reflects on the principle of equal treatment as a constant feature that pervades the European Union’s legal order and its specific role in competition law. Throughout history, this principle has been a foundation stone for developing the characteristics, such as freedom of movement, that one would consensually recognise as distinctive features that make the European Union a sui generis political construction. After a brief analysis of the principle’s development and ever-expanding contours, with new instruments emerging along the way and contributing to its importance, we will focus on the application of this principle to competition law. Paying particular attention to the Google Shopping case, we will demonstrate how the general principle of equal treatment remains relevant when confronted with new types of discriminatory abuses.
A Combined Endodontic Management Approach in immature Permanent Molar tooth with Periapical Lesion: Case Report
Authors: Baş Aybike , Çetin Muhammed Talha , Şimşek Derelioğlu Sera
Published: December 2023

Immature dental pulp, which has a highly cellular structure and a rich vascular nutrition system, is highly resistant to inflammation, In these teeth, determining the treatment option based on clinical and radiographic findings alone may result in the removal of diseased pulp tissue as well as vital pulp tissue. In order to increase the prognosis of these teeth, vital pulp treatments are highly recommended to preserve pulp vitality. By evaluating the condition of the root pulps of young permanent molars separately, it is possible to increase the prognosis of the tooth by combining regenerative endodontic treatment and pulpotomy treatment according to the condition of the pulps. In this case report, regenerative endodontic treatment and pulpotomy treatment were applied to different root canals of the first molar, which became necrotic before completing its maturation due to caries and had an apical lesion, and excellent healing was demonstrated.

Key words: Biodentine, immature permanent teeth, periapical lesions, pulpotomy, regenerative endodontic treatment.
Ein verhaltensökonomischer Blick auf das Problem der Knappheit
Authors: Döring Thomas
Published: December 2023

Der effiziente Umgang mit der Knappheit von Gütern und Ressourcen unter der Annahme rational handelnder Akteure ist ein zentraler Gegenstandsbereich der Volkswirtschaftslehre. Die Verhaltensökonomik ergänzt diese Perspektive, indem untersucht wird, wie sich das Erleben von Knappheit insbesondere in der ebenso bedeutsamen wie weit verbreiteten Ausprägungsform von Armut negativ auf die individuelle Fähigkeit zu deren rationaler Bewältigung auswirkt und wie dem durch staatliches Handeln begegnet werden kann.
Trennungen von Mitarbeitern wie vereinbart umsetzen
Authors: Munser René K.
Published: December 2023

Trennungen von Mitarbeitern kommen in der Wirtschaft oft vor. Das kann einzelne Fälle, aber auch sehr viele Mitarbeiter auf einmal betreffen. Wie Trennungen vorzubereiten und durchzuführen sind, ist in der Literatur hinreichend diskutiert worden. Dennoch treten in der Praxis nicht selten Widersprüche zwischen den geplanten Trennungsmodalitäten und der Trennungsrealität auf. Der folgende Beitrag entwickelt Lösungsansätze dafür, Trennungen integer zu Ende zu bringen.
Performance Feedback mit digitalen Instrumenten
Authors: Werther Simon , Plank Isabelle , Wendt Michael
Published: December 2023

Digitale Feedbackinstrumente und die Nutzung von People Analytics können dazu beitragen, Performance Feedback möglichst effektiv zu gestalten. Dieser Beitrag zeigt aktuelle Entwicklungen aus Theorie und Praxis auf und geht insbesondere auf Anwendungsmöglichkeiten für Blue Collar Mitarbeitende ein.
Unternehmenssteuerung von MANN+HUMMEL im Kontext von Transformation und Innovation
Authors: Knauer Thorsten , Weissenbacher Emese
Published: December 2023

MANN+HUMMEL ist ein weltweit führendes Unternehmen in der Filtrationstechnologie. Die Gruppe mit Hauptsitz in Ludwigsburg entwickelt unter den beiden Geschäftsfeldern Transportation und Life Sciences & Environment intelligente Filtrations- und Separationslösungen, die eine saubere Mobilität, saubere Luft, sauberesWasser und saubere Industrie ermöglichen. Investitionen in Forschung und Entwicklung sowie in ein globales Forschungsnetzwerk sind daher von essenzieller Bedeutung für die Gruppe. Mit seinen Lösungen leistet das 1941 gegründete Familienunternehmen einen wichtigen Beitrag zu einer sauberen Erde und der nachhaltigen Nutzung begrenzter Ressourcen. Im Jahr 2022 erwirtschafteten über 22.000 Mitarbeiter an mehr als 80 Standorten einen Umsatz von 4,8 Mrd. EUR. Im Zuge von Innovation und Transformation gilt das Controlling als wesentlicher Faktor für eine erfolgreiche Umsetzung der Unternehmensstrategie.
EDUCANDO ATRAVÉS DE VALORES SOCIOAMBIENTAIS NO ENSINO DE GEOGRAFIA DO 6º ANO DO SEGMENTO FUNDAMENTAL NO RIO DE JANEIRO (BRASIL)
Authors: Iglesias de Andrade Lívia , Pinheiro da Silva Augusto César
Published: December 2023

La enseñanza de geografía en la educación básica, especialmente en el sexto año de la primaria, debe ser orientada a las concepciones del “lugar”. Se cree que el uso de este concepto espacial contribuye a la formación ciudadana de los estudiantes, siendo este responsable por la reconstrucción de valores éticos y sociales eficaces para el entendimiento de los sostenibilidades en el espacio. Los estudiantes de las escuelas primarias pueden crear una relación simbiótica entre la educación geográfica y las acciones sostenibles que se reflejan en sus lugares de acción. En este sentido, las metodologías de acción docente deben seguir la elaboración de proyectos didácticos que amplíen los conocimientos sobre la ética ambiental, preparándose los estudiantes para el pleno ejercicio de la ciudadanía a través de relaciones de afecto, solidaridad, respecto y responsabilidad con la colectividad y el medio ambiente.
CONTENT OF FATTY ACIDS AND LIPID PEROXIDATION PRODUCTS IN THE BLOOD SERUM OF YOUNG UKRAINIAN BEEF BREED UNDER THE ACTION SALT OF COPPER, SELENIUM AND MANGANESE
Authors:   Dnipro State Agrarian and Economic University, Ukraine, Mylostуva D. , Gutyj B. ,   Dnipro State Agrarian and Economic University, Ukraine, Borshenko V. ,   Dnipro State Agrarian and Economic University, Ukraine, Marenkov O. ,   Dnipro State Agrarian and Economic University, Ukraine, Yaremko O. ,   Dnipro State Agrarian and Economic University, Ukraine, Lesnovska O. ,   Dnipro State Agrarian and Economic University, Ukraine, zhboldina O. ,   Dnipro State Agrarian and Economic University, Ukraine, Mylostyvyi R. ,   Dnipro State Agrarian and Economic University, Ukraine, Farafonov S. ,   Dnipro State Agrarian and Economic University, Ukraine, Levytskyy T. ,   Dnipro State Agrarian and Economic University, Ukraine, Kushnir H. ,   Dnipro State Agrarian and Economic University, Ukraine, Ryvak H. ,   Dnipro State Agrarian and Economic University, Ukraine
Published: December 2023

Fatty acids have a significant impact on the overall metabolic processes in the body. One of the links of the general metabolism is the formation of peroxidation products during the oxidation of fatty acids. The aim of our work was to investigate the relationship between the content of fatty acids and lipid peroxidation products under copper, selenium, and manganese deficiency. The study was conducted on calves of the Ukrainian meat breed aged 6 months. An appropriate dose of deficient trace elements was added to the basic diet of the experimental groups. Determination of the spectrum of fatty acids in blood serum was performed using a gas chromatograph. The diet with copper, selenium and manganese increased the content of short-chain saturated fatty acids and the level of monounsaturated fatty acids decreased. The obtained results indicate the influence of individual fatty acids on the formation of peroxidation of products as a result of increased oxidation of the corresponding substrates. It is shown that deficient copper, selenium and manganese affect the correlation between fatty acids and peroxidation products. The revealed regularities can become the basis for the development of sound strategies for the mineral nutrition of beef cattle by including deficient trace elements and polyunsaturated omega fatty acids. In addition to obtaining important data on the relationship between biochemical processes in the body of beef cattle, the study of the influence of dietary strategies on the nutritional value and fatty acid composition of beef is provided by our further research.
Benzodiazepinе derivative methanindiazenone modulates lipid metabolism in the liver of rats with rotenone-induced Parkinson’s syndrome
Authors:   Taras Shevchenko National University of Kyiv, Ukraine, Shtanova L.Ya. , Vesеlsky S.P. ,   Taras Shevchenko National University of Kyiv, Ukraine, Yanchuk P.I. ,   Taras Shevchenko National University of Kyiv, Ukraine, Tsymbalyuk O.V. ,   Taras Shevchenko National University of Kyiv, Ukraine, Moroz O.F. ,   Taras Shevchenko National University of Kyiv, Ukraine, Reshetnik E.M. ,   Taras Shevchenko National University of Kyiv, Ukraine, Moskvina V.S. ,   Taras Shevchenko National University of Kyiv, Ukraine, Shablykina O.V. ,   Taras Shevchenko National University of Kyiv, Ukraine, Kravchenko О.V. ,   O.O. Bogomolets National Medical University, Kyiv, Ukraine, Khilya V.P. ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: December 2023

Parkinson’s disease (PD) is a neurodegenerative condition for which the exact causes remain elusive, and no effective treatments currently exist. The pathogenesis of PD is believed to involve oxidative stress, mitochondrial dysfunction, and lipid metabolism disorders. A benzodiazepine derivative JM-20 has demonstrated protective effects on mitochondria in both neurons and peripheral tissues of rats with rotenoneinduced Parkinson’s syndrome (PS). This study aimed to analyze bile composition and assess the impact of a new benzodiazepine derivative, methanindiazenone, on lipid metabolism in the liver of rats subjected to the rotenone model of PS. The results indicated that, compared to the control group, bile concentration of phospholipids, cholesterol, cholesterol esters, and triglycerides decreased by 24.3, 26.2, 25.8, and 27.5%, respectively. With methanindiazenone treatment at doses of 0.5 and 1.0 mg/kg, all these metrics reverted to the control level. However, in the rotenone+methanindiazenone 2.0 mg/kg group, the levels of phospholipids, cholesterol, and cholesterol esters (except for triglycerides) surpassed the control values by 33, 28.1, 28.4 and 33.5%, respectively. Methanindiazenone positively impacted the motor behavior of rats with the rotenone model of PS and enhanced their survival rates. Therefore, at doses of 0.5 and 1.0 mg/kg, methanindiazenone not only improved lipid metabolism in the liver but also the overall well-being of rats with the rotenone model of PS. However, a 2 mg/kg dose of methanindiazenone displayed toxic effects, as seen from the increased content of phospholipids, cholesterol, and cholesterol esters in bile. Hence, methanindiazenone holds potential as a therapeutic agent for PS and possibly other neurodegenerative diseases related to lipid metabolism impairment, but its use should be limited to doses of 0.5 and 1.0 mg/kg.