bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Preferential Recharge Zones in Karst Systems Based on the Correlation between the Spring Level and Precipitation: A Case Study from Jinan Spring Basin
Authors: Chen Yuan , Shu Longcang , Li Hu , Opoku Portia Annabelle , Li Gang , Xu Zexuan , Qi Tiansong
Published: November 2021

The Jinan spring basin is located in the karst area of northern China, where springs serve as important sources of water supply. Several studies on spring protection and water supply have been carried out, and scholars have developed some laws on local groundwater flow dynamic and characteristics of aquifer structures. Unfortunately, there is a lack of detailed research on preferential recharge zones, which are the main recharge pathways of springs. Therefore, this research focuses on identifying preferential recharge zones based on the correlation between the spring level and precipitation. The results show that when precipitation is more intense or lasts longer, there is a stronger correlation between spring level and precipitation. It has been established that the precipitation at Donghongmiao station has the closest relationship with the dynamic of Baotu spring, which is found to be the most significant contribution to spring preservation. Two potential preferential recharge zones in the Jinan spring basin are detected through correlation analysis and geological exploration data. These findings support spring protection and water supply projects in karst regions.
Impact of Temperature on the Performance and Character of the Methanogenic Community of a Fixed-Bed Anaerobic Reactor at Psychrophilic Temperature
Authors: Zhao Hongyan , Liu Hongdou , Sun Yu , Zhang Liqiang , Fazl Ullah , Piao Renzhe , Wang Weidong , Cui Zongjun
Published: November 2021

To determine the effects of a gradual temperature decrease on reactor performance and the microbial community, four fixed-bed reactors that were packed with a biofilm carrier were operated for 217 days. The temperature of the reactors was decreased from 30 °C to 3 °C. The reactors initially soured at 3 °C and recovered when they were returned to 4 °C, as indicated by the stabilization of biogas production, methane production, VFA concentration, pH, and the COD removal rate. Our results also revealed that methanomicrobiales were the dominant methanogen, the concentration of the 16S rRNA gene in the carbon-fiber carrier sludge exceeded the same gene concentration in the deposited sludge, and that the carbon-fiber carrier played an important role in methanomicrobiale colonization at low temperatures. We suggest that 4 °C is the low-temperature threshold for optimal reactor performance.
Dimercaptosuccinic Acid Functionalized Polystyrene Column for Trace Concentration Determination of Heavy Metal Ions: Experimental and Theoretical Calculation Studies
Authors: Haseen Uzma , Ali Syed Ghazanfar , Umar Khalid , Ali Abuzer , Ahmad Hilal , Khan Haris Manzoor
Published: November 2021

Metal ion studies in wastewater are required on a regular basis for environmental monitoring and assessment. Less metal ion concentrations and the interference from complex sample matrices remains challenging for instrumental quantification. Herein, we proposed a fix-bed solid phase extraction method, consisting of a newly prepared dimercaptosuccinic acid functionalized polystyrene beads. The ligand forms stable complex with Hg(II), Pb(II), and Cd(II), evident by experimental as well as density functional theory. The metal-ligand stabilization energy calculations, suggested the higher selectivity of polystyrene dimercaptosuccinic acid (PSDMSA) toward Pb(II) compared to Cd(II) and Hg(II). The prepared adsorbent was utilized to enrich Hg(II), Pb(II), and Cd(II) ions from environmental samples. Column parameters were studied in detail and optimized accordingly. The preconcentration factor for Hg(II), Pb(II), and Cd(II) were found to be 900, with the preconcentration limit of 0.74 µg L−1. The detection limit for Pb(II), Cd(II), and Hg(II) ions was found to be 1.3 ± 0.2, 1.5 ± 0.3, and 1.8 ± 0.3 ng L−1, respectively. The method accuracy was tested against systematic and continuous errors by standard addition method (<5% RSD). Real samples was successfully analyzed following the proposed method.
Applying Risk Indices to Assess and Manage Soil Salinization and Sodification in Crop Fields within a Mediterranean Hydro-Agricultural Area
Authors: Tomaz Alexandra , Costa Maria João , Coutinho João , Dôres José , Catarino Adriana , Martins Inês , Mourinha Clarisse , Guerreiro Isabel , Pereira Maria Margarida , Fabião Marta , Boteta Luís , Patanita Manuel , Palma Patrícia
Published: November 2021

Irrigation-induced or secondary salinization can occur when salts are introduced by irrigation water and accumulate within the root zone due to insufficient leaching. Mediterranean regions are especially susceptible, given the predominant climate and the expanding of irrigation areas. In this study, two indices to assess the risk of salinization (RSA) and sodification (RSO), previously applied at a regional scale, were used in a hydro-agricultural area (AHA) in Southern Portugal, in ten crop fields. Information on climate, irrigation water quality, soil characteristics, and land use was obtained from large databases and from local data. The results revealed the feasibility of using the RSA and RSO indices both on large and smaller scales, seeing as most of the area in the monitored crop fields presented the same risk classes (62% in RSA and 78% in RSO). Deviations were due to the reduction in scores for drainage and, in the case of RSO, the assigned irrigation method based on the land occupation class. Considering that different spatial scales of risk assessment are associated with different objectives and management options, a risk management framework was outlined following a multi-scale perspective for mitigation actions in salt-sensitive areas, ranging from territorial planning to the adoption of on-farm practices that can contribute to the sustainability of irrigated agriculture.
Assessment of Coagulation–Flocculation Process Efficiency for the Natural Organic Matter Removal in Drinking Water Treatment
Authors: Mustereț Corina Petronela , Morosanu Irina , Ciobanu Ramona , Plavan Oana , Gherghel Andreea , Al-Refai Malek , Roman Ioana , Teodosiu Carmen
Published: November 2021

Natural organic matter (NOM) represents a range of heterogeneous hydrophobic and hydrophilic components naturally occurring in the water source and, due to the fact that they can act as precursors for the disinfection, by-products may have a considerable impact on drinking water quality. Coagulation–flocculation (C/F) is among the most applied processes for NOM removal from water sources (especially rivers). In this study, C/F efficiency for a river water supply was investigated in cold and warm conditions, by varying the coagulant dose and mixing conditions. In this study, polyhydroxy aluminum chloride PAX XL 60, and polyacrylamide FloPam AN 910 SEP were used as coagulant and flocculant, respectively. Multiple water quality indicators were determined, such as turbidity, chemical oxygen demand (COD), dissolved organic carbon (DOC), and residual aluminum concentration. Some unconventional parameters relevant for NOM removal were also considered, like absorbance at 254 nm (A254), at 280 nm (A280), and at 365 nm (A365), as well as the ratios A254/DOC, A254/280, and A254/A365. After coagulation–flocculation, turbidity was completely removed in all the studied conditions. The DOC content was reduced by up to 22.65% at a low temperature and by up to 31.81% at a high temperature. After the addition of polyelectrolyte in cold conditions, the efficiency in terms of A254 increased by up to 37.4%, while the specific absorbance decreased. The high molecular weight NOM increased after C/F, based on the A254/A365 ratio. Chemometric analysis was employed in order to determine the effect of the coagulant dose on the process efficiency. The optimum coagulation–flocculation conditions were corroborated by means of the principal component analysis.
Uranine as a Tracer in the Oil and Gas Industry: Determination in Formation Waters with High-Performance Liquid Chromatography
Authors: Król Anna , Gajec Monika , Kukulska-Zając Ewa
Published: November 2021

In the oil and gas industry, tracers are used to estimate residual oil saturation, to indicate the location and orientation of fractures in tight reservoirs, to identify and mark the direction of fluid flow in fractured deposits, to locate faults and discontinuities, and to measure fluid movement in injection wells during drilling. The tracers should behave in a mechanically similar manner to the tested substance, e.g., formation waters, oil or gas, and, on the other hand, they should significantly differ from them in terms of chemical properties so that it is possible to identify them. One of the fluorescent tracers used in the oil and gas industry, e.g., for inter-well tests during secondary or tertiary production methods (especially during reservoir hydration), is uranine. In order to assess the effectiveness of fluid movement measurements, it is necessary to determine the uranine content in formation waters. In this study, a method was developed to determine uranine in formation water samples using high-performance liquid chromatography with fluorescence detection (HPLC/FLD). The initial step in preparing samples for chromatographic analysis would be solid phase extraction (SPE). The method was validated and allows for the determination of uranine in formation water samples in the concentration range from 0.030 to 2.80 µg/L. The validation of the method included the analysis of factors influencing the measurement result (sources of uncertainty), determination of the linearity range of the standard curve, determination of the quantification limit of the method, and verification of the reproducibility, selectivity, stability and correctness achieved. The method developed within the study can be successfully applied in the case of the determination of uranine content in formation water samples from the oil and gas mining industry, which are often unstable and characterized by a relatively complex matrix. After validation, the method will also be applicable to the determination of uranine in matrices with a similar physicochemical composition, e.g., to assess groundwater flow in deformed carbonate aquifers or to characterize faults that act as barriers to horizontal groundwater flow.
Research on High Power Factor Single Tube Variable Structure Wireless Power Transmission
Authors: Yang Yi , Zhang Xuejian , Luo Lei , Xie Shiyun , Zhou Qingshan
Published: November 2021

Aiming at the problems existing in the current radio energy transmission system, we propose a wireless power transmission (WPT) system with the parallel–parallel (PP)-compensated structure. The transmitter of the transmission system adopts a separate topological structure to suppress the current shock and noise. In order to improve the efficiency of the WPT, reduce the static loss, and reduce the current oscillation loss on the power side, the input current ripple can be improved by two parallel phase-shifting methods. In this paper, two topological theories are analyzed, and the simulation and experiment results verify the correctness of these theories under both static and on-load conditions. After the final two-way phase-shift, 61.99% of the ripple is reduced. It provides a new approach for the design of WPT systems with PP structure.
Multi-System Coupling DMi Hybrid Vehicle Modeling and Its Performance Analysis Based on Simulation
Authors: Li Song , Wang Puxi , Zeng Dong , Peng Wenjie , Yang Liu
Published: November 2021

Key subsystems, such as driving resistance, component performance, and energy management strategy, determine the power performance and energy consumption of hybrid electric vehicles. Qin Plus performs excellently in fuel consumption due to its low driving resistance, high thermal efficiency of the engine, and multi-factor multi-mode energy management strategy. This article aims to explain the outstanding energy consumption of DMi vehicles by analyzing the driving resistance, component parameters of Qin Plus and introducing the drive modes selection and vehicle energy management strategy through multi-system modeling and simulation. The ultra-low fuel consumption of 3.8 L is obtained under the NEDC driving cycle and evaluated by the corresponding experiment.
THE BRYOPHYTE FLORA OF BEREHOVE TOWN (TRANSCARPATHIA, UKRAINE)
Authors: Virchenko V.
Published: November 2021

Berehove is the district center in the Transcarpathian region. The town is located within the Transcarpathian lowland, in the valley of the Tysa river. Its area occupies of 19 square kilometres where about 24 thousand population lives. At the beginning of the XX century, bryophytes of the Transcarpathians studied Polish, Hungarian and Czech botanists. After the Second World War, these studies continued Ukrainian researchers, namely M.P. Slobodyan, S.V.  Melnyk and others. In general, 27 species of bryophytes were known to our research.In 2018 and 2020, a modern bryofloristic study of Berehove was carried out. The botanical reserve «Ardov» was examined, as well as some parks and street plantations, where more than 80 packets of mosses were collected. As a result of the generalization of own and literary data in the town of Berehove and its surroundings, 71 species of bryophytes have been established, of which 5 species liverworts and 66 ones of mosses. Leading places in the spectrum of moss families occupy Brachytheciaceae, Pottiaceae and Orthotrichaceae. The richness of bryophyte species is observed mainly on natural and artificial rocky substrates, trunks of trees, after that – on the ground. In the botanical reserve «Ardov», a number of mosses are growing, which are not detected within the built-up part of Berehove. In this town, apart from widespread mosses, some rare in Ukraine species, namely Syntrichia latifolia, Dicranoweisia cirrata, Rhynchostegium megapolitanum are known.
TOPICAL ISSUES OF THE STUDY OF ORDINARY APRICOT (PRUNUS ARMENIACA L.) IN THE FOREST-STEPPEZONE OF UKRAINE
Authors: Кrasovsky V. , Cherniak T. , Hapon S. , Ishchenko V.
Published: November 2021

It is determined the relevance of the study of ordinary apricot from the Central Asian group in order to obtain dried fruit in the forest-steppe zone of Ukraine. The kinds and forms of the Central Asian group bear smaller, but high-sugar fruit. It is important to notice nowadays markets and supermarkets offer dried apricots imported from Kyrgyzstan, Azerbaijan, Uzbekistan, Georgia, Turkey, Iran and other countries. The process of introduction of subtropical fruit crops P. armeniaca.was started in Khorol botanical garden. There is the sort P. armeniaca, belonging to the Central Asian group (September dried apricot) grown in Uzbekistan. The height of the experimental tree is above seven meters, its crown consists of four skeleton branches, its trunk diameter is fourteen meters. In 2021 it was in blossom at the beginning of May. This sort grown in the forest-steppe zone of Ukraine is characterized by bearing regular fruits. It is being planning to study the biochemical content of the fruits, their sugar content and dry content and producing dried fruits. In 2020 it was taken the sample of Kyrgyz apricot for science experiment of introduction P. armeniaca. Its fruits are fleshy. During drying they are practically stored as whole fruits. This apricot sort grown in Kyrgyzstan is characterized by dehydration and drying in the trees. It gives an opportunity to get dried apricots by natural way.
CURRENT TRENDS IN RESEARCH OF INFLUENCE OF γ-RADIATION AND ULTRAVIOLETE RADIATION ON PLANTS
Authors: Yuzyk M. , Lyubinska L. , Optasyuk O. , Hrygorchuk I.
Published: November 2021

The article reveals the current problems of the influence of γ-radiation and ultraviolet radiation on plants. An overview of the most important scientific results of modern research and prospects for their use in various spheres of human life. It is shown that depending on the dose of absorbed radiation in plants, different radiobiological effects are manifested. The study of the adaptive capacity of plants to different stressors is relevant for predicting the sustainability of ecosystems with increasing anthropogenic load in general and radiation in particular
VASCULAR PLANTS OF POLTAVA TOWN TERRITORIAL COMMUNE: AN ANNOTATED CHECKLIST
Authors: Davydov D. , Gomlya L.
Published: November 2021

The paper summarized the data about vascular plant species of Poltava town territorial commune formed in 2020 during decentralization reform within Poltava district of Poltava region. Based on own field research in 2006–2021 authors found on this territory 996 vascular plant species from 105 families. They include 911 species from 432 genera and 101 families which are resident taxa and belong to a stable components of a plant cover on this territory; they grow a long time here and have a regular self-healing ability. The annotated list of resident plant species with main their synonymic Latin names is indicated. 85 species from 77 genera and 32 families have also been found on the research territory but they are not to be able to accept as a stable component of a plant cover since they are locally distributed, occasionally escaped from cultivation or alien and are not naturalized here.These species were included in the additional list indicated in this paper too; they need a monitoring research for their status and further distribution on this territory. It was established that the territory of Poltava town commune has a great species diversity of vascular plants: 63,3% of resident taxa which were found in the Left Bank Forest-Steppe of Ukraine and 73,9% of resident taxa found in Poltava region have been discovered by authors. The features of Poltava town commune are high participation (61 species or 6,1%) rare vascular plant species – 14 from «The Red Data Book of Ukraine» and 47 regionally rare plant species within Poltava administrative region, and rather low degree of preservation area (0,3%). So the priority task for the development of Poltava town territorial commune in a direction of a biodiversity conservation is to be creation of new preservation territories on areas with the high concentration of rare vascular plant species.
RARE FLORA AND VEGETATION OF THE BORZHAVSK MOUNTAIN MASSAGE OF THE UKRAINIAN CARPATHIANS AND PROSPECTS OF THEIR PROTECTION
Authors: Felbaba-Klushina L. , Guklyvska A.
Published: November 2021

The Borzhavsky mountain range of the Ukrainian Carpathians has long served as a fodder base for livestock and the richest massif of blueberry reserves in the Ukrainian Carpathians. Therefore, its flora and vegetation have undergone significant changes. Nevertheless, a number of nature protection sites, mostly forest reserves, (with a total area oabout 4,000 hectares) have been created around the subalpine meadows (Polonyny). At the same time, polonyny still remain unprotected. In the study area we identified 32 species of vascular plants included in the Red Book of Ukraine (2009) and seven plant communities included in the Green Book of Ukraine (2009). The article presents their sozological, synphyto sozological and biotopic analysis. More representatives of the flora grow in the subalpine meadows, which indicates the need for their protection. Among them there are 9 rare, 15 vulnerable and 8 invaluable species. The largest number of coenopopulations of the rare relict arcto-alpine species Diphasiastrum alpinum (L.) Holub is concentrated in this massif in the Ukrainian Carpathians.Some other sozophytes (Lunaria rediviva L., Lilium martagon L., Allium ursinum L.) and rare forest communities with their participation are most often found on it. Among the rare communities are three associations with the status of "endangered" and four associations with the status of "rare".
Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
Authors: Huang Tao , Zhuang Zhenhuang , Heianza Yoriko , Sun Dianjianyi , Ma Wenjie , Wang Wenxiu , Gao Meng , Fang Zhe , Ros Emilio , Del Gobbo Liana C. , Salas-Salvadó Jordi , Martínez-González Miguel A. , Polak Jan , Laakso Markku , Astrup Arne , Langin Dominique , Hager Jorg , Hul Gabby , Hansen Torben , Pedersen Oluf , Oppert Jean-Michel , Saris Wim H. M. , Arner Peter , Cofán Montserrat , Rajaram Sujatha , Tuomilehto Jaakko , Lindström Jaana , de Mello Vanessa D. , Stancacova Alena , Uusitupa Matti , Svendstrup Mathilde , Sørensen Thorkild I. A. , Gardner Christopher D. , Sabaté Joan , Corella Dolores , Martinez J. Alfredo , Qi Lu
Published: November 2021

Objective
. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (
TCF7L2
). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of
TCF7L2
rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs).
Methods
. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies.
Results
. In the joint analysis, a total of 7 eligible RCTs were included (

n
=
4,114

). Importantly, we observed a significant effect modification of diet/lifestyle-related interventions on the
TCF7L2
variant rs7903146 and changes in fasting glucose. Compared with the control group, diet/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg/dL (test for heterogeneity and overall effect:

I

2

=
45.1
%

,

p
<
0.05

;

z
=
2.20

,

p
=
0.028

) per one copy of the
TCF7L2
T risk allele. Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of
TCF7L2
risk allele.
Conclusions
. Our findings suggest that carrying the
TCF7L2
T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.
Clinical and Para-clinical Features of Brucellosis With and Without Spondylodiscitis
Authors: Keramat Fariba , Hashemi Seyyed Hamid , Esna-ashari Farzaneh , Kaseb Kaveh
Published: November 2021

Background: Brucellosis is a common zoonotic disease with protean clinical manifestations. Osteoarticular involvement is the most common complication of the disease. This study aimed to compare the clinical and para-clinical manifestations of brucellosis among the patients with and without spondylodiscitis. Methods: In this comparative and cross-sectional study, 135 patients having brucellosis with and without spondylodiscitis and admitted to Sina hospital in Hamadan, Iran from March 2009 to March 2014 were included. Clinical and para-clinical data of the patients were obtained from their medical records in the hospital based on a designed checklist. Results: Thirty-five patients having brucellar spondylodiscitis (BS) with the mean age of 55.60±14.31 years, and 100 patients having brucellosis without BS with the mean age of 43.27±18.35 years were examined. A significant difference was found between the mean age of the patients with spondylodiscitis and that of those without spondylodiscitis (P<0.001). All patients with spondylodiscitis complained of back pain and vertebral tenderness, while 60% of the patients without BS suffered from back pain but experienced no vertebral tenderness (P=0.003). The most common vertebral involvement in spinal MRI of the patients with BS was L4-L5 (45.7%). Patients with spondylodiscitis had more increased ESR and CRP than those without spondylodiscitis (P<0.001). Conclusion: It is recommended that Brucellar spondylodiscitis be considered in the differential diagnosis of the patients with prolonged fever, back pain, and vertebrae tenderness in the endemic areas.
COVID-19 Severity and Comorbidities in Diabetic Patients
Authors: Samimagham Hamid Reza , Hassani Azad Mehdi , Arabi Mohsen , Hooshyar Dariush , Sheikhtaheri Abbas , Khorrami Farid , Hosseini Teshnizi Saeed , Kazemi Jahromi Mitra
Published: November 2021

Background: This study aimed to investigate the demographic factors, comorbidities, and laboratory results of diabetic patients with coronavirus disease 2019 (COVID-19) severity. Materials and Methods: This cross-sectional study enrolled 171 diabetic patients with COVID-19 admitted based on chest CT scan findings to the COVID-19 ward of Shahid Mohammadi Hospital in Hormozgan, Iran from 1 March to 1 June, 2020. Reverse-transcriptase polymerase chain reaction (RT-PCR) test was performed, and the patients were divided into three groups (mild, moderate, and severe) based on the severity of disease. Then we investigated the demographic factors, comorbidities, and laboratory results of diabetic patients with severe COVID-19 severity. Results: Regarding comorbidities, there was no significant difference between the three groups. Moreover, there was a significantly lower lymphocyte count in the severe group compared to moderate and mild groups (P = 0.001). We showed the increase in blood urea nitrogen (BUN) and creatinine to be significantly associated with increased disease severity (P = 0.001 and P = 0.009, respectively). We also showed a significant difference in aspartate aminotransferase (AST) levels between different groups of patients (P = 0.002) with a higher level of AST in the severe group (P = 0.020). Lactate dehydrogenase (LDH) and troponin were also significantly associated with an increase in COVID-19 severity in patients with diabetes (P = 0.013 and P = 0.002, respectively). Conclusion: There was a significant association between disease severity and BUN, creatinine, AST, LDH, and troponin levels in diabetic patients with COVID-19. There was no significant association between different groups regarding severity of disease and comorbidities.
Trend Analysis of Cutaneous Leishmaniasis Incidence in Izeh County During 2014-2019
Authors: Ahmadi Mirqhaed Marziyeh , Dastoorpoor Maryam , Behbahani Abdolamir
Published: November 2021

Background: A cutaneous form of leishmaniasis (cutaneous leishmaniasis, CL) is becoming increasingly common, and this study was conducted to investigate the epidemiological features of CL in the county of Izeh in Khuzestan province. Materials and Methods: This retrospective cross-sectional research was performed during 2014- 2019. Basic demographic and clinical information was gathered from patients with CL referring to Izeh health centre and then processed using SPSS software, version 25.0. Results: Overall, data related to 131 patients were recorded from 2014 to 2019. The incidence of CL showed a decrease from 16.207 to 5.028 per 100000 individuals in Izeh. Based on the analysis of CL incidence in Izeh county, a statistically significant difference was observed through the mentioned six-year study (P<0.05). Male patients with a frequency rate of 65.6% demonstrated a statistically significant association in the CL and the type of gender compared to 34.4% of females (P<0.05). The age group of 20-29 years old (32.1%) had a higher frequency of CL in the age groups. Finally, there was a statistically considerable discrepancy in the frequencies of infected people with CL related to age groups (P<0.05). Conclusion: Based on the findings and other epidemiological characteristics, Izeh does not seem to be an endemic focus of CL. Nonetheless, it is a concerning situation, and proper preparation is strongly advised for disease control and prevention.
An Updated Review of the Gestational Diabetes
Authors: Hafizi Moori Mozhgan
Published: November 2021

High blood glucose levels during pregnancy can lead to unfavorable outcomes in the mother, fetus, and neonatal state. This review focused on the latest guidelines on diagnosis, monitoring, and treatment of gestational diabetes mellites. This narrative review was conducted by searching through several online databases including PubMed, Science Direct, and Embase for relevant articles using keywords such as "Gestational Diabetes", "Diabetes Mellitus", "Pregnancy", and "guideline" with no date limitations. Based on the literature review, proper treatment of diabetes during pregnancy results in a normal pregnancy, labor, postpartum state. The key to a normal pregnancy is to control and keep your blood sugar levels within the recommended range by various guidelines, which were the discussion subjects of this narrative review in detail. In addition to maintaining normal blood sugar levels before or during pregnancy, there should be a balance between diet, exercise, and insulin intake if indicated for treatment. Gestational diabetes control program needs close monitoring and appraisal with progression in the pregnancy. As a result, recognizing the burden of gestational diabetes is decisive for timely diagnosis and further evaluations by healthcare policymakers. Overall, multiple updates on the guidelines of gestational diabetes management are annually published, and a comparison of these guidelines could inform clinicians to update their approach.
Atypical Presentation of Aortic Dissection: A Case Report
Authors: Shamizadeh Soraya , Faridaalaee Golamreza
Published: November 2021

Background: Aortic dissection (AD) is considered to be one of the life-threatening diseases. Quick diagnosis has great significance so that a one-hour delay in treatment leads to a 1-2% increase in mortality. Case Report: The 55-year old obese woman with epigastric pain and right upper quadrant pain referred to the emergency department of our hospital. The acute coronary syndrome was our initial diagnosis but an image similar to a Perl in one cut and a crescent in another cut of computed tomography (CT) drew our attention in the mediastinal view of CT without intravenous contrast that was performed to rule out coronavirus disease-19 (COVID-19). Finally, CT-angiography was requested and AD diagnosis was approved accordingly. Conclusion: The presence of calcification on a non-contrast chest CT in the middle of the aorta or away from the artery wall can be a sign of AD. Thus, special attention should be paid to the atypical symptoms of AD.
Anthropometric outcome in low birth weight infants treated with erythropoietin; a randomized clinical trial
Authors: Mojabi Seyed Hooshyar , Mohammadkhaniha Farahnaz , Kakavand Azita , Alizade Shahrivar Ardeshir
Published: November 2021

Introduction: Erythropoietin (EPO) is a glycoprotein hormone, which has a key role in the number of red blood cells in mammalian blood. Objectives: The aim of this study was to evaluate whether EPO is associated with anthropometric outcomes in low birth weight infants. Patients and Methods: This study was conducted on 90 premature neonates aged under 35 gestational weeks, with the weight of less than 2000 g, and selected through convenience sampling. The subjects were assigned to EPO (n=45) and control groups (n=45) by random allocation with the aim of evaluating the relationship between EPO and anthropometric outcome, hemoglobin, and hematocrit in low birth weight infants. The weight and head circumstance of the infants were measured on their birthdays, and days 14, 28, and 42. Additionally, hemoglobin and hematocrit were measured on days 7 and 42. From day 14, EPO injection was given to the EPO group three times a week for one month (12 times). The dosage for each baby was 100 U/kg of 2000 unit ampules which was given as a subcutaneous injection in the baby’s arm. Results: The mean weights on birthday and day 42 in the EPO group were 1397±270 g and 2614±739 g, respectively, while in the placebo group they were 1280±281 g and 1486±208 g, respectively. In addition, the mean head circumstance on birthday and day 42 in the EPO group was 28.6±1.7 cm and 33±2.5 cm, respectively, while in the placebo group it was 27.8±2.3 cm and 29.8±2.2 cm, respectively. Conclusion: According to the results of the current study, weight gain and head circumstance gain rose significantly in the EPO group compared with the placebo group (P<0.001). Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials website (identifier: IRCT20160511027853N2, https://en.irct.ir/trial/47069, ethical code; IR.QUMS.REC.1398.133).
Evaluation of mast cell count in oral and cutaneous lichen planus lesions
Authors: Koochak Dezfouli Mohammad , Montazer Fatemeh , Shiva Atena , Moosazadeh Mahmood , Biglari Abhari Maryam , Alidoust Hadi , Zamanzadeh Maryam
Published: November 2021

Introduction: Lichen planus (LP) is a relatively common chronic mucocutaneous disorder diagnosed based on clinical manifestations and histopathological findings. Mast cells (MCs) are multifunctional immune cells that are involved in the pathogenesis of LP by releasing certain chemical mediators. Objectives: The purpose of this comparative study was to estimate the number of intact (granulated), degranulated and total MCs in oral lichen planus (OLP) and cutaneous lichen planus (CLP) lesions. Patients and Methods: The present descriptive-analytical and cross-sectional study was conducted on 125 LP blocks, including 40 OLP samples and 85 CLP samples. The mean number of granulated, degranulated and total MCs were counted under light microscope (×100 and ×400). Data were analyzed by SPSS version 24 software using Mann-Whitney U and Pearson’s chi-square tests. Results: The mean total MC count was 14.92 ± 3.90 in OLP samples and 14.04 ± 5.60 in CLP samples respectively which was not statistically significant. The mean granulated MC count in CLP (10.53 ± 5.70) was higher than in OLP (4.34 ± 3.46) (P<0.001). The mean degranulated MC count in OLP (10.57 ± 2.99) was higher than in CLP (3.51 ± 2.72) (P<0.001). Conclusion: No statistically significant difference was observed in the total MC count between OLP and CLP; however the difference in the degranulated MC count was detected between OLP and CLP. Despite the homogeneity in the total MC count, the MCs appear to play different pathological roles in OLP and CLP.
Cotoneaster manna oral drop for the management of neonatal hyperbilirubinemia; a randomized, double-blinded and placebo controlled clinical trial
Authors: Fakhri Moloud , Farhadi Roya , Azadbakht Mohammad , Akbari Jafar , Yousefi Seyede Seddigheh , Mousavinasab Nouraldin , Davoodi Ali
Published: November 2021

Introduction: Neonatal hyperbilirubinemia is a common physiologic condition, which is occurred in early days after birth with an estimated incidence of about 50% in term neonates. Objectives: The aim of this study was to evaluate the effect of Cotoneaster nummularioides manna on reducing neonatal total serum bilirubin (TSB) levels, and shortening hospitalization period. Patients and Methods: One hundred breast-fed term neonates with hyperbilirubinemia were randomly assigned to the intervention group or control group. The Newborns of the intervention group were received Cotoneaster manna drop in the dosage of 1 g/d divided into three doses every 8 hours for at least 3 days and the control group received placebo drops. Total serum bilirubin levels were measured at baseline, at 12, 24 hours and then daily through hospitalization days (day 9). Secondary outcome (discharge from hospital, TSB <10 mg/dL) was also documented with risk ratio calculation. Results: TSB levels were declined in both groups; however, this was more prominent in the manna group than the placebo group. The greatest difference of mean TSB levels between the intervention and control groups was seen on days two (10.01 versus 13.04 mg/dL; mean difference [95% CI]: - 3.03 [-3.60 to -2.46]; P<0.001). On day four, significantly more newborns in the intervention group versus the control group were discharged (70% versus 6.1%; risk ratio = 11.43, 95% CI= 3.76, 34.74). No major side effects were recorded in both groups. Conclusion:Cotoneaster nummularioides manna drop combined with phototherapy was superior to the control group in reducing TSB levels and reaching this observation more rapidly and shortening hospitalization period with no major side effects. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical trials (identifier: IRCT20160531028188N4; https://en.irct.ir/trial/27765, ethical code #IR.MAZUMS.REC.1394.1316).
The relationship between social support and life expectancy in cancer patients during chemotherapy;an original study
Authors: Hajigholami Ali , Yusefzadeh Mehrdad , Amini Pozveh Zahra , Ansari Hourieh
Published: November 2021

Introduction: Developing patients’ tolerance in receiving treatment and enhancing their life expectancy has been increasingly recognized as the important end-points in cancer disease. Objectives: This cross-sectional study aimed at exploring the relationship between received social support and its correlation with life expectancy in cancer patients during chemotherapy. Patients and Methods: Around 210 cancer patients were selected through simple sampling procedure from the clinics of Isfahan medical science University, Iran. Sherbourne and Stewart questionnaire and Miller questionnaire were used to assess social support and life expectancy, respectively. The collected data were analyzed by independent t test and linear regression. Results: We found a significant positive correlation between total social support score and life expectancy scores. Additionally, a significant positive correlation between different aspects of social support — tangible support, emotional support and kindness—with positive social interaction and life expectancy was detected. Conclusion: Our results highlights that social support may develop life expectancy in cancer patients depending on the extent of disease; however, extensive and longitudinal studies on social support and life expectancy in cancer patients should be performed.
Secretome of adipose derived stem cells induced apoptosis in anaplastic thyroid carcinoma C-643 cells
Authors: Rezaei-Tazangi Fatemeh , Samadi Ali , Azandeh Saeed , Khoshnood Saeed , Mahmoudvand Shahab
Published: November 2021

Introduction: Previous studies have proven that secretory materials of mesenchymal stem cells (MSCs) (secretome) have remedial properties. Objectives: The main goal of this study was to evaluate the effects of secretome of adipose-derived MSCs on growth and apoptosis in anaplastic thyroid carcinoma (ATC) C-643 cells. Materials and Methods: Initially, thyroid carcinoma cells were exposed to the 25 and 50 μg/mL adipose-derived stem cells (ADSCs) secretome for 24 and 48 hours, to evaluate the proliferation and cytotoxicity of the C-643 cells, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test and colony assay was conducted. Acridine orange/ethidium bromide (AO/EB) staining was conducted to evaluate the apoptosis. The expression level of apoptosis-associated genes was determined by real-time polymerase chain reaction (PCR) technique. Results: Cell viability and colony numbers in groups exposed to secretome were significantly lower than the control group. The amount of apoptosis-related genes (Bax/Bcl-2, P53, caspase-3 and caspase-8) expression in secretome-treated groups was more than the control group. Conclusion: The data revealed that ADSCs secretome caused the significant reduction of cell growth and induced apoptosis in C-643 cells.
Treatment Parameters of Photobiomodulation in the Prevention of Non-surgical Cancer Treatment-Induced Oral Mucositis: A Review of Preclinical Studies
Authors: Agbele Alaba Tolulope , Hejazi Sedigheh Marjaneh , Dehpour Ahmad Reza , Mohammad Jafari Razieh , Elyassi Arash , Bagheri Mahmoud , Seydi Mojtaba
Published: November 2021

Introduction: The most important side effect after non-surgery cancer treatment (NSCT) is oral mucositis (OM) which degrades the quality of life. Using photobiomodulation (PBM), formerly known as low-level laser therapy (LLLT), in the prevention of NSCT-induced OM was widely studied. Hence, this review evaluates the efficacy of optical treatment parameters behind the working process of PBM in preventing NSCT-induced OM in preclinical studies. Methods: Using the PubMed, Scopus and Embase databases, the present study systematically reviewed existing preclinical studies for optical treatment parameters of PBM in preventing NSCT-induced OM in experimental models without restriction on the year of publication. Results: In total, 51 articles were recognized during the search of the literature, and only 16 research papers were included in this review, taking into consideration the inclusion as well as exclusion benchmarks. The reviewed studies showed that a consensus has yet to be reached on the optimal PBM treatment parameters in preventing NSCT-induced OM. However, a wavelength of 660 nm, a power density of 40 mW as well as fluence which ranged between 2 and 6 J/cm2 were mostly utilized in the included studies. Furthermore, the severity of NSCT-induced OM was reduced following PBM application with no reported severe side effects. Conclusion: The efficacy of PBM with the associated optical parameters is a promising strategy in preventing NSCT-induced OM. However, the optimal parameters of PBM need to be investigated.
Development of a Minimally Invasive and Non-invasive Lipolysis Laser System for Effective Fat Reduction
Authors: Lee Ji-young , Oh Seok-won , Ryu Han-young , Seo Young-seok
Published: November 2021

Introduction: Obesity is a global problem because it causes various complications. Methods for reducing fat for healthy life are being studied. In this study, we developed a minimally invasive and non-invasive lipolysis laser system for effective fat reduction. Methods: The laser had the wavelengths of 1980 nm and 2300 nm which have very good absorption of fat and water. We developed a minimally invasive laser system that breaks down fat by direct irradiation of fat tissue. This minimally invasive laser system uses a 808 nm diode laser and Nd:YVO4 to generate the 1064 nm wavelength, which is the pumping source of the nonlinear crystals. It is a mid-infrared lipolysis laser system having two wavelengths of 1980 nm and 2300 nm by controlling the temperature of nonlinear crystals. We also developed a non-invasive laser system that reduces fat with hyperthermia treatment by raising the temperature of adipocytes with a 1060 nm penetrating depth into the skin. In this non-invasive laser system, the In gallium arsenide (GaAs) diode laser is irradiated on the skin with an area of 4 × 8 cm2 through the hand-piece. The cooling system in the hand-piece protects the skin from burns. We studied the effectiveness and safety of each system through animal experiment. We studied the effects of lipolysis when these two systems were combined. Results: This research uses new wavelengths (1980 nm, 2300 nm) to increase the fat reduction effect with low energy (1.3 W). After using the 1060 nm (1.1 W/cm2 ) wavelength laser, when the 1980 nm and 2300 nm (1.3 W) laser were used, a lipolysis effect of about 35 % was obtained. Conclusion: We have developed a 1.3 W mid-infrared (1980 nm, 2300 nm) laser with good lipolysis effect with low power.
Effect of Apical Size and Taper on the Efficacy of Root Canal Disinfection With LED Photodynamic Therapy as an Adjunct to Irrigation With Sodium Hypochlorite
Authors: Alimadadi Hoda , Asnaashari Mohammad , Naseri Mandana , Yadegari Zahra
Published: November 2021

Introduction: This study assessed the effect of apical size and taper on the efficacy of root canal disinfection with LED photodynamic therapy (PDT) as an adjunct to irrigation with sodium hypochlorite. Methods: A total of 126 extracted human mandibular molars were divided into 4 groups. The mesiobuccal canal was prepared to size 25/4% in group 1, 25/6% in group 2, 30/4% in group 3, and 30/6% in group 4 using the iRaCe rotary system. A 21-day Enterococcus faecalis biofilm was prepared and used for inoculation of the canals. Each group was randomly divided into 3 subgroups for canal disinfection with 2.5% sodium hypochlorite, sodium hypochlorite plus LED PDT and saline (positive control). Samples from the root canals were obtained with rotary files and cultured. Microbiologic data were analyzed using the Poisson regression test. Results: The bacterial count significantly decreased following disinfection with sodium hypochlorite with/without PDT in all sizes and tapers of preparation compared with the control group (P<0.05). Increasing the apical taper or apical size and the use of PDT as an adjunct did not have a significant effect on the reduction of the bacterial count (P>0.05). However, the apical size and PDT had a significant effect on the number of residual bacteria (P<0.05), and increasing the apical size and conduction of PDT significantly decreased the number of residual bacteria. Conclusion: The apical size and taper and the use of PDT as an adjunct did not have a significant effect on the reduction of the bacterial count. However, increasing the apical size and conduction of PDT as an adjunct to sodium hypochlorite irrigation significantly decreased the number of residual bacteria in the root canal system.
Comparison of the Effectiveness of Combined Diode Laser and GLUMA Bonding Therapy With Combined Diode Laser and 5% Sodium Fluoride Varnish in Patients With Dentin Hypersensitivity
Authors: Asna Ashari Mohammad , Berijani Amirreza , Anbari Fahimeh , Yazdani Zahra , Zandian Amin
Published: November 2021

Introduction: Dentin hypersensitivity (DH) is one of the most common complaints of patients referred to a dental office, so this study aimed to compare the effectiveness of combined diode laser and GLUMA bonding therapy with combined diode laser and 5% sodium fluoride varnish in patients with DH. Methods: Sixty patients were divided into three groups (bonding, laser-bonding, laser-varnish), and before the intervention, the amount of DH was measured with the visual analogue scale (VAS) scale. In the bonding group, GLUMA Desensitizer solution was applied and then air-dried. In the bonding-laser group, first bonding was used, and then the affected tooth was irradiated with a diode laser. In the varnish-laser group, 5% sodium fluoride varnish was coated and then the laser was irradiated with the said method. DH was measured immediately after the treatment and then 2, 7 and 30 days after the treatment. Results: Laser-varnish treatment was not different from laser-bonding treatment at all measurement times (P=1). Laser-varnish and bonding treatment were not significantly different up to one week after the intervention, but on the 30th day after the intervention, the difference in pain was significant (P=0.01). There was no significant difference in laser-bonding treatment up to one week after the intervention, but on the 30th day after the intervention, the difference in pain was significant (P=0.003). Conclusion: The combined treatment with GLUMA bonding and the 660 nm diode laser is effective in reducing DH and this is more effective than GLUMA bonding alone in the long term. However, it does not have a significant advantage over the combined varnish-laser method, but it seems that due to its ease of use, it can be a suitable alternative to the varnish-laser method.