bluuebunny/crossref_metadata_2025 huggingface dataset:
Linezolid Tolerability in Drug Resistant TB Patients and Its Future use in all Oral Shorter Regimens
Authors:   Senior Technical Advisor MDR TB, NTP Myanmar, USAID Global STAR Project, Asif Muhammad , Myint Zaw ,   Senior Consultant TB, NTP Central Branch Yangon, Myanmar
Published: September 2023

Linezolid (Lzd) belongs to group of Oxazolidinones a repurposed drug to treat Drug resistant TB (DR TB). WHO in 2019 placed Lzd in Group A Drugs along with Levofloxacin/Moxifloxacin and Bedaquiline as most effective drugs to treat RR/MDR TB. The RR/MDR TB regimen should be constructed with a combination of at least 4 likely effective drugs. The toxicity profile of Lzd may feature from 22% to 80% and among most common toxicities are myelosuppression and neuropathy and such frequent toxicities lead from temporary interruption to permanent discontinuation of Lzd during RR/MDR TB treatment. The median time to development of toxicity is around 5-6 months of treatment but toxicity may occur even during early weeks of treatment. The Linezolid (Lzd) usual dose of 600 mg OD is also used for <28 days to treat various gram-positive infections. Linezolid toxicity is frequent but relatively easy to detect and manage and is reversible other than complete nerve damage if not detected early and drug interrupted timely. Linezolid (600 mg daily) is also part of WHO recommended BPaLM and BPaL regimens which are safe, shorter, low cost and highly effective as future RR/MDR TB treatment. To ensure safety of patients all TB programs must ensure appropriate adverse drug safety, monitoring and management (DSM) mechanism as essential component of Drug resistance TB treatment.
Perbicaraan Mengikut Undang-Undang Adat dalam Perkahwinan Komuniti Orang Asli Semai di Pos Bersih, Perak
Authors: Nordin Mohd Firdaus , Man Zanisah
Published: September 2023

Makalah ini dijalankan bagi membincangkan mengenai perbicaraan mengikut undang-undang adat dalam perkahwinan komuniti Orang Asli Semai. Makalah ini menggunakan kaedah kualitatif. Seramai 8 orang informan yang berumur 45 tahun ke atas dipilih menggunakan teknik persampelan bertujuan. Kaedah yang digunakan dalam kajian ini ialah kajian perpustakaan, temu bual, pemerhatian dan rakaman. Lokasi Pos Bersih dijadikan sebagai lokasi kajian. Dapatan kajian menunjukkan terdapat 3 tahap perbicaraan berdasarkan undang-undang adat dalam perkahwinan dalam komuniti tersebut iaitu di peringkat waris, peringkat Stin dan peringkat tertinggi iaitu di peringkat Batin. Melalui gabungan peranan yang dimainkan oleh pemimpin adat serta pegangan kukuh terhadap nilai dan norma di kalangan ahli komuniti telah menyumbang kepada kehidupan berumah tangga yang harmoni. Walaupun mengaplikasikan undang-undang tidak bertulis yang tiada kesahan di sisi undang-undang rasmi yang lain, namun ianya telah berfungsi dalam menjaga aturan sosial dalam konteks adat resam bagi komuniti tersebut. Pengamalan undang-undang ini juga sebagai mekanisme yang menyumbang kepada keharmonian hidup di kalangan ahli komuniti yang saling bergantungan antara satu sama lain.
Analysis of the modern school in times of pandemic in Ecuador
Authors: Armendariz Carolina , Milla Alexandra , Yumisa Diego , Acosta Diego
Published: September 2023

This research examines how the COVID-19 pandemic has impacted education in Ecuador. The challenges in the implementation of online education are analyzed, and the solutions adopted to guarantee educational continuity amid the health crisis are explored. In addition, the pandemic has revealed gaps in access to technology and connectivity in the country, making equitable access to online education difficult for all students. Likewise, the emotional and psychological impact that the pandemic has had is addressed, and the importance of providing psychosocial support during these difficult times is highlighted. The main results show different factors associated with school dropout during the pandemic, including the lack of families' financial resources and the need for technological equipment to sustain connectivity between the student and the teacher.
Marketing plan to improve business positioning
Authors: Valentin Puma Javier Daniel , Manriquez Zapata Hector Miguel , Espitia Sosa Flor Itala , Odar Puse Marco Antonio , Ramirez Galvez Marco Antonio , Valentin Huanaco Yesenia Paulina
Published: September 2023

This paper analyzes marketing from the perspective of public land transport companies. The study includes a review of the current situation of transport companies. From this reality, a proposed marketing plan promotes customer attraction, improvements in customer service, and the inclusion of partners committed to the company's growth and development. The results show that a proper marketing plan can grow the business while projecting an attractive image to the transport sector. In addition, it was observed that marketing and its implementation can change how users perceive the company and its employees.
ACESSO A SERVIÇOS DE ÁGUA E SANEAMENTO NO BRASIL EM ÁREAS VULNERÁVEIS
Authors: Gomes Galvão Basílio Débora
Published: September 2023

O acesso aos serviços de água e saneamento em países de baixa ou média renda é limitado pelas condições de pobreza e vulnerabilidade da população. Nesse contexto, urge estabelecer políticas públicas para se tenha o acesso econômico a esses serviços e para que estes sejam mais abrangentes a população, assegurando o equilíbrio entre os objetivos sociais, ambientais e financeiros, tripé da sustentabilidade. Este artigo contribui para uma melhor compreensão dessas políticas de saneamentos em áreas vulneráveis e da dificuldade de acesso universal. Discute-se o papel da regulação na consecução dos objetivos normativos em áreas vulneráveis e o impacto recente do novo marco regulatório ocorrido no Brasil. As diferentes experiências analisadas podem ser boas práticas a serem aplicadas em outros países. Uma das principais conclusões desta pesquisa está relacionada às contribuições que a regulamentação deve trazer na universalização e na localização das políticas de saneamento, principalmente quando a prestação desses serviços é regida por contrato. Ademais, o poder público deve ser mais efetivo e, principalmente, mais proativo para que a universalização seja alcançada.
Influence of Family Structures on Students’ Progression in Public Secondary Schools in Ndhiwa Sub-County, Homabay County, Kenya
Authors: Owuor Emmanuel , Ochieng Pamela , Kirimi Josephine
Published: September 2023

Purpose: Students’ progression in secondary schools is important in the realization of educational objectives. However, in Ndhiwa Sub-county, students’ progression rates has been low in many public secondary schools. Many students drop out of secondary schools just a few years after enrollment.  Thus, the purpose of this was to study to examine how family structures influence students’ progression in public secondary schools in Ndhiwa Sub-county, Homabay County, Kenya.

Methodology: This research adopted mixed methodology and applied concurrent triangulation research design. Target population was 1263 respondents which comprised 65 principals, 678 secondary school teachers and 520 parents’ representatives from which 305 respondents were sampled using Yamane’s Formula. Stratified sampling was applied to create five strata based on the number of zones in Ndhiwa Sub-county. From each zone, five principals and five parents’ representatives were sampled purposively. However, from each zone, simple random sampling was applied to select 51 teachers. This procedure realized a sample size of 25 principals, 25 parents’ representatives and 255 teachers. Qualitative data were analyzed thematically based on the objectives and presented in narrative forms. Quantitative data were analyzed using descriptive statistics such as frequencies and percentages and inferentially using multiple linear regression model in Statistical Package for Social Sciences (SPSS Version 23) and presented using tables.

Findings: The study established that students’ progression has been low with many students who get enrolled in Form I not able to complete their secondary education. This is attributed to large family sizes and family structures.  

Unique Contribution to Theory, Practice and Policy: As a practice, parents should plan their families and bring forth families they can comfortably take care of such that the meagre amount of financial resources available can cater for the education. As a policy, the Ministry of Health and the Division of National Family Planning should continue with their efforts to teach people on the essence of bring forth families they can manage. The study’s unique contribution is that it will reinforce an understanding of how specific aspects of each family structure influence of students’ progression in public secondary schools.
Chili Pepper as a Functional Food: Relevance to Lesotho
Authors: Sello Mamakase , Lekatsa Teboho
Published: September 2023

Purpose: Although the use of chili peppers as functional foods in Lesotho is not well documented, their production and consumption have a rich historical background. Functional foods are those that serve as therapeutic agents in addition to nutrition. Previous research supports the many health benefits of consuming chili peppers, including their potential to mitigate the risk of cancer, cardiac arrhythmias, rheumatism, and chest colds. Nevertheless, these concepts have yet to translate into tangible alterations in policies and implementation strategies. Therefore, this review aims to identify potential topics for future research on Chili peppers, food, and therapeutic food product development; to improve the population's health and well-being 

Methodology: This paper presents a literature analysis of existing data on chili peppers as functional foods, specifically emphasizing their applicability to Lesotho, a developing country.

Findings: Based on the analysis of the reviewed research, it can be inferred that those who regularly incorporate chili peppers into their diet exhibit a decreased risk of death from non-communicable diseases compared to those who do not.

Unique Contribution to Theory, Practice and Policy: The data presented in this review supports the classification of chili pepper as a functional food while also emphasizing the importance of investigating the effectiveness, safety, quality, development, and possible hazards of chili peppers, particularly in developing nations like Lesotho. The present study has great potential to provide novel global perspectives on the associations between chili peppers, non-communicable diseases (NCDs), and mortality to guide future research. Hence, future research endeavors must thoroughly examine the distinct impacts of chili peppers through more clinical studies. Moreover, the present review and further research will contribute to revising Lesotho’s dietary guidelines and advancing functional food products, such as herbal supplements derived from chili peppers.
CAPILARIOSE URINÁRIA EM FELINO: RELATO DE CASO
Authors: França Matos Neto José , Da Silva Pereira Edivaldo , Vieira Moura Diogo , Venancio dos Santos Yago , Nael Seixas Felipe , Satake Fabiana , Shelda Pessoa de Melo Valeska
Published: September 2023

O presente trabalho tem por objetivo relatar um caso de capilariose urinária diagnosticada em um felino adulto, com obstrução uretral, atendido em uma clínica veterinária de rede privada na cidade de Natal, Rio Grande do Norte. Os exames hematológicos revelaram anemia normocítica normocrômica, linfopenia e hiperproteinemia no hemograma; bem como, níveis muito elevados da ureia e creatinina nas análises bioquímicas. Os achados de imaginologia revelaram alterações morfológicas nos rins sugestivas de nefropatia crônica. Na urinálise, proteinúria e presença de leucócitos foram encontrados na sedimentoscopia. O diagnóstico de capilariose urinária foi definido pela identificação dos ovos de Capillaria spp. no exame do sedimento urinário. Além disso, não foram observados cristais nem urólitos nas vias urinárias, sugerindo que a obstrução foi causada na uretra pelo acúmulo de ovos do parasita que impossibilitou a micção. Vale ressaltar que Capillaria spp. são causadores de doença do trato urinário inferior em felinos, apresentando sintomatologia quando a infecção é massiva. Embora diversos exames auxiliem mostrando possíveis alterações compatíveis com a doença, o diagnóstico definitivo pode ser dado através do exame de sedimento urinário, onde serão observados ovos do parasita com características singulares compatíveis com o gênero.
NÍVEIS PRESSÓRICOS DE ESTUDANTES UNIVERSITÁRIOS: UMA REVISÃO NARRATIVA
Authors: dos Santos Sousa Juliana , Caetano de Azevedo Brenda , Oliveira Pachú Clésia
Published: September 2023

A vivência acadêmica promove mudanças no estilo de vida dos estudantes, pois os jovens adotam alternativas práticas e rápidas para se alimentar. Objetivou-se analisar os níveis pressóricos de estudantes universitários por meio de uma revisão narrativa realizada no período de junho a julho de 2023, através de  artigos científicos completos de acesso livre, publicados em português no período de 2012 a 2022. Como fonte de coleta foram utilizados os bancos de dados BVS Saúde, SciELO e Google Acadêmico com os termos Estudantes universitários, Hipertensão arterial, Níveis pressóricos. Foi possível observar que o público estudado tinha propensão a desenvolver Hipertensão Arterial Sistêmica (HAS), doença que se apresenta como multifatorial, caracterizada por níveis elevados e sustentados da Pressão Arterial (PA) igual ou maior a 140/ 90 mmHg. Por se tratar de uma patologia com causas múltiplas, desde fatores modificáveis aos não modificáveis, o excesso de peso, estresse e o sedentarismo lideram a posição de variáveis contribuintes para o desencadeamento do aumento dos níveis pressóricos de estudantes universitários. Assim, confirmando a necessidade de ações de saúde para sua prevenção, uma vez que, a elevação dos níveis tensionais, futuramente refletirá em uma propensão aumentada para o desenvolvimento de HAS. Pode-se concluir que o acompanhamento de flutuações na PA serve como uma forma de rastreamento da hipertensão e pré-hipertensão, logo, a realização de atividade física, aliada com alimentação saudável, se mostra eficaz para prevenção e controle da HAS.
Az account-based marketing fogalma, elterjedése és szerepe a B2B marketing gyakorlatában
Authors: Özvegy Adrián , Tessényi Judit
Published: September 2023

Az account-based marketing (ABM) stratégia kifejezetten a B2B piac számára lett kifejlesztve, magyarul fiókalapú marketinget jelent. A B2B kereskedelem alatt a vállalatok közötti együttműködés révén létrejövő üzleti tranzakciókat értjük. Account-based marketing során a fiókok azok a vállalatok, amelyeket megcélzunk és számukra nagy mértékben személyre szabott marketing kampányokat készítünk, azzal a céllal, hogy minél jobb kapcsolatot építsünk ki az adott vállalattal. Dolgozatunkban a fogalom körülhatárolása mellett annak leglényegesebb típusait és eszközeit mutatjuk be - néhány gyakorlati példán keresztül. A szekunder adatok elemzése mellett a leggyakoribb ABM eszközök SWOT analízisét végeztük el.
The Decline of Lake Victoria Ferry Services in Kenya, 1961-2012
Authors: Budi Nashon Budy , Orondo John Akumu , Okuro Samwel , Odhiambo George
Published: September 2023

Purpose: This study examined the operations of Lake Victoria Ferry Services since the independence of the East African countries in 1961 when the management was under the East Africa Railways and Harbors (EARH) and later the Kenya Railways Corporation (KRC). At the beginning of the 20th century the British colonial government established Lake Victoria transport as an extension of railway line in the lake region in Kenya and into Uganda. Despite some challenges, lake transport demonstrated progress in its services and expansion during the colonial period. However, when the management was transferred to the independent governments of East Africa, the operations of ferries were affected by the inefficiencies which marked the beginning of its decline. This study was guided by Politics of the Belly Theory of Bayart who associates underdevelopment of Africa long after independence with corrupt practices of African leaders. The theory shows that postcolonial African leaders have personalized the state for their own and their ethnic community’s gain thereby neglecting the regions which are perceived to be opposing the ruling regime.

Methodology: A Historical Research Design was used to conduct this study. Non probability sampling methods and procedures were used to identify informants during the collection of primary data. Other primary data were gathered from Kenya National Archives and Railways Museum in Nairobi. Secondary data was collected from relevant publications and other materials.

Findings: The data obtained were analyzed using content and thematic analysis techniques.  This study established that transition in management from colonial to independent East African governments, competition from road transport and disintegration of East African Community led to the decline of maritime transportation on Lake Victoria. In order to revive ferry services on the Lake, major rehabilitations on the existing ports must be done and modern ports built. In the same vein new transport vessels should be acquired. Finally, a permanent solution to the threat of water hyacinth must be pursued and regular dredging of navigational channels done regularly.

Unique Contribution to Theory, Policy and Practice: This study suggests that, the government should promote integrated transport planning as well as developing proper regulations guiding Lake Victoria transport.
Soil Environmental Study Analysis of Mining Areas in the Yangshan Gold Belt,Gansu
Authors:   Civil-Military Integration Geological Survey Center, China Geological Survey, Chun ZHAN , Hu YANG ,   Civil-Military Integration Geological Survey Center, China Geological Survey, Yang ZHAO ,   China University of Geosciences, Junfeng HU ,   Civil-Military Integration Geological Survey Center, China Geological Survey, Jia WANG ,   Civil-Military Integration Geological Survey Center, China Geological Survey, Mingyuan ZHANG ,   Civil-Military Integration Geological Survey Center, China Geological Survey
Published: September 2023

The Yangshan gold deposit in Gansu province is a super large gold deposit in the West Qinling metallogenic belt, with a cumulative gold accumulation of 400 tons. The soil environment conditions in Anba- Getiaowan ore section were investigated and analyzed to provide a reference basis for mine construction, development and treatment. A total of 120 samples (95 horizontal profile samples and 25 vertical profile samples) were collected, taking into account the topography, cover type, soil use type and soil type in the study area, and the distribution characteristics and change patterns of soil heavy metals As, Cd, Hg and Pb in the study area were evaluated sterically from both horizontal and vertical dimensions. Meanwhile, the distribution characteristics of F and Se elements in soil were compared and analyzed. The results of the study showed that: (1) the value of heavy metal elements As exceeded the standard, and the rest of the heavy metal elements were above the second grade of soil quality, among which the exceedance rate of heavy metal elements As in Anba area was 15%, and that in Getiaowan area was 84%; (2) the average value of As, F and Se content was higher than the background value of Longnan City, which was speculated to be significantly related to the presence of high arsenic and high fluorine water in the evaluation of poor quality water in the study area; (3) the excessive content of As element in the soil in the mining area is related to the occurrence of arsenic-containing minerals in gold, and As element pollution problem should be emphasized in the later construction and development of the mine.
Research on Seismic Velocity Inversion Method Based on Deep Learning
Authors:   China National Offshore Oil (China) Corporation, Wang XU , Feiyi WANG ,   School of Earth and Space Sciences, Peking University, Zhiqiang ZHANG ,   China National Offshore Oil (China) Corporation, Gongli LIU ,   China National Offshore Oil (China) Corporation, Xinyi DUAN ,   China National Offshore Oil (China) Corporation
Published: September 2023

Methods for obtaining seismic velocity include offset velocity analysis, tomography velocity inversion and full waveform. inversion, but these methods all share common problems: As the amount of seismic data increases, the time required to process the data to obtain the seismic velocity increases exponentially, and the latter two methods are more dependent on the initial seismic velocity. To address the problems of the above methods, this paper improves a seismic velocity inversion method based on deep learning. At the same time, a method that can generate a large number of velocity models randomly with geological features (undulation layer, faults, anomalies, etc. ) similar to those of real subsurface structures is also proposed. The generated velocity model and fluctuation equation for forward modeling are used to perform. the forward modeling, which allows for the efficient establishment of data set. The basic principle of the improved deep learning inversion method in this paper is as follows: the characteristic information of the training data is extracted by convolution neural network, which is trained with large data to obtain a nonlinear mapping relationship between seismic record and seismic velocity. In the inversion stage, the seismic velocity can be inversed quickly by inputting the seismic records into the trained network. In order to make the network give full play to the advantages of processing seismic data, the authors obtained the dominant network structure by means of numerical simulation, and achieved satisfactory inversion results. Finally, through comparative experiments, this paper verifies the advantages and applicability of the method.
Bibliometric and Visual Analysis of Natural Capital Studies
Authors:   College of Marine Technology and Environment, Dalian Ocean University, Jinshui LIANG , Yuan LI ,   College of Marine Technology and Environment, Dalian Ocean University, Zengqiang YIN ,   College of Marine Technology and Environment, Dalian Ocean University
Published: September 2023

Natural capital is an important part of the ecological service systems, a necessary condition for human survival and development, and an important support for the sustainable and healthy development of the three dimensions of society, economy and environment. Based on the core ensemble database of Web of science (WOS) database, this paper uses CiteSpace and VOSviewer software to visualise and analyze the subject development trend and hot research of natural capital from 2001 to 2022. The results show that: 1. The major publishing countries in natural capital are the United States, China, the United Kingdom, Australia and Canada, with the United States in first place followed by China, and China and the United States are far ahead of the rest of the world in natural capital research. 2. The Chinese Academy of Sciences, the Australian National University, the University of Oxford, Stanford University, the University of Queensland and Beijing Normal University are the top six publishers in natural capital research institutions, with the Chinese Academy of Sciences leading the way in terms of the number of articles published. 3. In the past 20 years, the number of articles published on natural capital research has been growing exponentially, with an explosive growth during 2013-2022. 4. Research hotspots cover resource management, sustainable development, climate change, ecological services, environmental protection and biodiversity, etc. , indicating that natural capital needs scientific and technological support from multi-disciplinary fields, and in-depth research in this field also promotes the development of other disciplines.
Nonlinear Scalarization Characterizations of E-Super Efficient Solution of Set-valued Vector Optimization Problem
Authors:   School of Mathematical Sciences, Inner Mongolia Universiy, Fengya LUO , Fei LI ,   School of Mathematical Sciences, Inner Mongolia Universiy
Published: September 2023

Abstract: In the study of vector optimization problems, the concept of (weakly) effective solution based on the definition of order cone and its properties play a very important role. The concept of superefficient solution is the unification of several existing concept of properly efficient solutions, while the E- super efficient solution of the vector optimization problem proposed based on the improvement set is an important extension of the classical concept of superefficient solution, which unifies the concepts of superefficient solution and ε-super efficient solution. Therefore, it is of great significance to study the E- super efficient solution and its related properties for the study of vector optimization problems. This paper mainly focuses on the relevant conditions of nonlinear scalarization characterization of E- super efficient solution: firstly, a sufficient and necessary condition for the nonlinear scalarization characterization about the E- super efficient solution of the set-valued vector optimization problem is obtained through the corresponding property of the seminorm p; secondly, the corresponding property of the distance function d is used to obtain another sufficient and necessary condition for the nonlinear scalarization characterization of the E- super efficient solution; then, according to the relationship between the E-optimal solution and the E-super efficient solution, a sufficient condition for the results of nonlinear scalarization characterization of the E- super efficient solution is derived by means of the distance-oriented function Δ-E which based on the improved set E under the condition of E=E+K0; finally, under the condition of 0∈clE, the distance-oriented function Δ-E is used to obtain a necessary condition for the nonlinear scalarization result of E- super efficient solution, and the corresponding sufficient and necessary result is deduced.
Discipline System of Water Science and Its Research Progress and Prospect
Authors:   School of Water Conservancy Engineering, Zhengzhou University, Qiting ZUO ,   Henan International Joint Laboratory of Water Cycle Simulation and Environmental Protection
Published: September 2023

Water science is an interdisciplinary science specializing in the study of water, and it involves many disciplines and a wide range of research areas. It is a science closely related to human survival, economic and social development, and the wellbeing and reproduction of nature and its all inhabitants. However, due to its complexity, universality, and multidisciplinary nature, the term “water science” has been widely mentioned and used but not standardized. Therefore, it is necessary to further sort out its concept and build its discipline system from the macro level and the level of disciplinary synthesis. Based on a large amount of data analysis, this paper summarized the relevant articles, monographs, and academic communication results since 2011 to propose an interpretation and define the concept and research scope of water science. Then, the discipline system of water science was elaborated, and the current research status and the prospect of water science in China as reflected in the “Report on the Progress of Water Science Research in China” was introduced. In addition, the future development trend of water science was expounded from five aspects, and five future development characteristics of water were then proposed. The research results can provide a reference for further standardizing the scope of water science research, analyzing the discipline system of water science, and shedding light to future development direction.
Tocolytic Effect of White Pepper (Piper nigrum Linn.) on Isolated Rat Uterine Contraction in vitro
Authors: Sawangjaroen Kitja , Sarnkhaeveerakul Pidyada
Published: September 2023

Piper nigrum Linn. (Pepper) is a very well-known spice used for different purposes such as human dietaries, medicine and preservative. In Thai traditional medicine, white pepper is a component of herbal formulas used to treat many disorders including symptoms of dysmenorrhea. It is of interest to investigate the effect of methanolic extract of white pepper (MEWP) on the isolated rat uterus contractions induced by various uterine stimulants and the possible mechanism(s) involved. Strips of uterus were prepared from estrogen-primed female Wistar rats, fixed in the organ bath filled with an appropriate physiological solution with carbogen bubbled continuously at 37 °C. The measurement of isometric tension was then performed using force transducer attached to a polygraph. MEWP was tested its effect on the uterine contraction and found the inhibitory effects on the contraction induced by oxytocin, PGF2α and depolarizing solution. TEA inhibited the uterine relaxing effect of MEWP while glibenclamide had no effects when the uterus was induced to contract with oxytocin. Propranolol abolished the uterine relaxing effect of isoproterenol while it had no effects on the relaxing effect of MEWP. The results suggested that MEWP is likely to be a general uterine relaxant. The effects may be due to the interference on Ca2+ influx into the uterine muscle cells which may involve the opening of KCa channel. The effect was unlikely to occur via the KATP-channel and may not involve the interaction of MEWP on b-adrenergic receptor on the uterine muscle cells.
HIGHLIGHTS

Methanolic extract of white pepper (MEWP) is likely to be a general uterine relaxant.
The uterine relaxing effect of MEWP may involve an inhibition of a rise in intracellular Ca2+ from both Ca2+ influx via plasma membrane of the uterine smooth muscle cell and probably Ca2+ release from internal storage.
The effect of MEWP may be mediated mainly through a reduction in Ca2+ influx, possibly through voltage dependent Ca2+
The effect of MEWP may involve with the opening of KCa channel, which may arise from direct action of MEWP on the calcium channel or be a consequence of an increase in [Ca2+]i.
The uterine relaxing effect of MEWP is unlikely to be mediated by an activation of β2 –adrenergic receptor.

GRAPHICAL ABSTRACT
Linfoma del manto blastoide en recaída con infiltración cutánea.
Authors: Chiang Hector , Pacheco Merchán Daniel , Muñoz Cárdenas Santiago , González Guzmán María del Carmen , Astudillo Bravo María Fernanda
Published: September 2023

La infiltración cutánea en el linfoma del manto es infrecuente de forma primaria (1-2% de los casos), mientras que de manera secundaria es usual en estadíos avanzados (17% de los casos) y variantes histológicas como la blastoide. Reportamos el caso de un paciente con linfoma del manto blastoide en recaída con infiltración cutánea.
Reporte de casos: leucemia/linfoma de células T del adulto asociada al virus HTLV-1
Authors: Freilich Franco Federico , De la Rua Luciana , Casiraghi Gabriel , Troccoli Josefina , Jaimovich David , Ross Solange , Bertolino Yamila , Torres Adriana , Quispe Daniel , Mazzeo Maria , Rey Irene
Published: September 2023

La leucemia/linfoma de células T del adulto (LLTA) es una neoplasia de células T maduras compuesta frecuentemente de células linfoides altamente pleomórficas. Aunque existen diferentes formas clínicas descritas, suele presentarse como una enfermedad diseminada y de pobre pronóstico, con compromiso generalizado de ganglios linfáticos, piel, hipercalcemia y expresión en la sangre periférica. Es causada por el retrovirus humano HTLV-1, infección necesaria pero no suficiente para desarrollar enfermedad, siendo observada con mayor frecuencia en las áreas endémicas. A continuación, presentamos 2 casos de pacientes adultos, con distintas manifestaciones clínicas, con el objetivo de destacar la importancia de la sospecha diagnóstica, el valor de los exámenes complementarios disponibles, y la necesidad de nuevas alternativas terapéuticas y estrategias efectivas de prevención de la transmisión viral.
Internet de las cosas (IoT)
Authors:   Universidad Técnica de Machala, Hernández Rojas Dixys , Mazon-Olivo Berth ,   Universidad Técnica de Machala, Escudero Carlos ,   Universidade da Coruña
Published: September 2023

El análisis de datos es un proceso complejo que trata de encontrar patrones útiles y relaciones entre los datos a fin de obtener información sobre un problema específico y de esta manera tomar decisiones acertadas para su solución. Las técnicas de análisis de datos que son exploradas en el presente libro son actualmente utilizadas en diversos sectores de la economía. En un inicio, fueron empleadas por las grandes empresas a fin de incrementar sus rendimientos financieros. El libro se basa en la aplicación de la especialización inteligente, de este modo, gracias al trabajo colaborativo, se combina al sector agropecuario con las tecnologías, matemáticas, estadística y las ciencias computacionales, para la optimización de los procesos productivos.
Inteligencia Artificial aplicada a datos agropecuarios
Authors:   Universidad Técnica de Machala, Ramírez-Morales Iván , Tusa Eduardo ,   Universidad Técnica de Machala, Rivero Daniel ,   Universidad de La Coruña
Published: September 2023

La inteligencia artificial (IA), podría sonar aún como un término de ciencia ficción, sin embargo muchas personas no se percatan de que están utilizándose cada vez más en actividades de la vida cotidiana. Los asistentes personales como Siri o Cortana, los vehículos autónomos, predicción de fraudes, o de condiciones idóneas de mercado, recomendaciones sobre tendencias, son entre otras aplicaciones de uso común. Una rama de la inteligencia artificial conocida como aprendizaje automático o aprendizaje máquina (machine learning - ML), se refiere a los algoritmos computacionales que son capaces de realizar acciones complejas, sin que éstos hayan sido explícitamente programados para ello, si no que estos algoritmos son más bien, entrenados para realizar esta tarea.
Outcomes of (chinese) mini-percutaneous nephrolithotomy for renal stones: a prospective trial
Authors: Refaat Hesham M. , Zaza Mohammed , Salem Tarek , Hassan Mohamed
Published: September 2023

Objective: Mini-percutaneous nephrolithotomy (mini-PCNL) has been recently advocated as a minimally invasive procedure for the management of renal stone. In this trial, we assessed the postoperative outcomes of chinese mini-PCNL (MPCNL) in adult patients with renal calculi less than 3 cm in diameter.
Material and methods: We performed a single-arm prospective trial that recruited adult patients with unilateral single kidney stones less than 3 cm. Patients were followed up for the assessment of postoperative complications and stone-free status.
Results: Sixty patients were included in the present study, with a mean age of 36.9 ±8.5 years and slightly male predominance (56.7%). The mean operative time was 133.7 ±29.2 minutes. None of the patients needed a nephrostomy tube or DJ tube stent. The mean hospital stay was 1.4±0.62 days.  Eight patients (13.3%) showed mild perinepheric collection on the postoperative US. All patients had mild postoperative pain, with no incidence of post-operative bleeding, residual stone, sepsis, or pelvi-calyceal injury. A total of four patients (6.7%) had a postoperative fever. The incidence of postoperative urine was 13.3%.
Conclusion: Chinese Mini-PCNL is an effective minimally invasive modality for the management of renal calculi less than 3 cm, with a low rate of postoperative complications and excellent stone-free status. Mini-PCNL can be used in well-resourced centres to reduce postoperative complications and hospital stay among patients with renal calculi.
El papel clínico de la ureteroscopia diagnóstica en el carcinoma urotelial del tracto urinario superior (UTUC): ¿vale la pena utilizarla?
Authors: Álvarez Juan Camilo , García-Perdomo Herney Andrés
Published: September 2023

El carcinoma urotelial del tracto urinario superior (UTUC) es una patología rara que representa del 5 al 10% de los carcinomas uroteliales. El diagnóstico se basa en imágenes (urografía por tomografía computarizada o urografía por resonancia magnética) y citología urinaria, con buena precisión diagnóstica. En casos dudosos, la ureteroscopia diagnóstica permite la confirmación histopatológica, una mejor estadificación e identificación de candidatos a cirugía conservadora de riñón. El objetivo fue describir el papel de la ureteroscopia diagnóstica y su relevancia clínica en pacientes con sospecha de UTUC. Presentamos una revisión no sistemática en PubMed, incluyendo fuentes adicionales por su relevancia.
En cuanto a los estudios clínicos, la urografía por TC o RMN tiene una sensibilidad y especificidad >90% con limitación para identificar lesiones planas. La citología urinaria tiene una tasa de detección que oscila entre el 43 y el 91% entre los métodos de muestreo. Cuando se utiliza ureteroscopia diagnóstica, se utilizan diagnóstico óptico, citología selectiva y biopsia. Las herramientas más utilizadas son el ureteroscopio flexible de fibra óptica, las cestas de alambre plano y las pinzas para biopsia en copa.
La ureteroscopia podría disminuir la tasa de nefroureterectomía radical (RNU) y los diagnósticos erróneos con confirmación histopatológica. También retrasa el tiempo hasta la RNU y aumenta la recurrencia intravesical (IVR) sin comprometer los resultados oncológicos (OS, CSS, MFS, RFS). La ureteroscopia diagnóstica es una herramienta valiosa en UTUC cuando hay incertidumbre clínica.
O que a (controversa) participação de Mileva Maric-Einstein nos trabalhos publicados por Albert Einstein entre 1901 e 1905 pode ensinar sobre a iniquidade de gênero na história da ciência?
Authors: Rodrigues Renato Felix , Gedoz Laís
Published: September 2023

Desde a década de 1980 há uma intricada controvérsia com respeito à participação de Mileva Maric, a primeira esposa de Albert Einstein, na produção dos trabalhos acadêmicos publicados pelo marido no período entre 1901 e 1905. Este artigo se propõe a discutir a participação que Mileva teve na produção desses trabalhos. Para isso, a apresentação do episódio histórico é acompanhada por interpretações encontradas na literatura, de acordo com as quais Mileva pode ser vista como uma “caixa de ressonância” que não contribuiu com ideias próprias, ou como uma importante co-autora eclipsada pelo machismo dominante naquela época. Além de discutir a participação de Mileva na elaboração desses trabalhos, aproveitamos para incorporar contribuições oriundas dos estudos de gênero sobre a análise de episódios históricos como esse. Com esse respeito, discutimos obstáculos presentes na trajetória de mulheres cientistas como Mileva, problematizando como o discurso meritocrático pode ser utilizado como instrumento para desmerecer discussões sobre a iniquidade de gênero nas ciências. Os pontos levantados destacam a importância de que pesquisas sobre a história da ciência evitem armadilhas que contribuam para perpetuar esse cenário de iniquidade com relação ao gênero.
Person-Centered Interventions for Autistic Adults Ages 18+ (2013–2021)
Authors: Benevides Teal , Watling Renee , Robertson Scott Michael
Published: September 2023

Systematic review briefs provide a summary of the findings from systematic reviews developed in conjunction with the Evidence-Based Practice Program of the American Occupational Therapy Association. Each systematic review brief summarizes the evidence for a theme related to a systematic review topic. This systematic review brief presents findings from a systematic review of family- and person-centered planning interventions for autistic1 adults aged 18+ years gathered from literature published between 2013 and 2021.
Endovascular management of cerebral venous thrombosis: a tertiary-centre experience
Authors: Palanisamy Prabakaran , Kramadhari Harshith , Badachi Sagar , G.G. Sharath Kumar , Aggipothu Balakrishna , Mathew Thomas , Sarma G.R.K. , Nadig Raghunandan , M.V. Sucharitha , Deepalam Saikanth Reddy
Published: September 2023

Background

Stroke related to cerebral venous thrombosis (CVT) is uncommon, with untoward lethal outcomes. Systemic anticoagulation is the treatment of choice. However, some patients can be resistant to this treatment. Endovascular management with thrombolysis and mechanical thrombectomy can be a viable option in such cases.

Material and methods

We retrospectively reviewed the endovascular management used for CVT in 8 patients who failed to respond to standard anticoagulation therapy between December 2017 and December 2022 in our institute. Clinical profile, imaging parameters, endovascular procedure details, and outcomes in terms of angiographic findings and clinical follow-up were analysed.

Results

: In this period, a total of 8 patients underwent mechanical thrombectomy. The procedure was successful in all cases (8/8 = 100%), and 50% of them showed near total/complete recanalization; Perforation of the cortical veins was noted in 2 cases (~25%). Among the 8 patients, one died (1/8 = 12.5%) due to cardiac aetiology; the remaining 7 patients (87.5%) showed good clinical outcome with a modified Rankin Scale score 0 to 2.

Conclusions

Catheter-directed thrombolysis with mechanical thromboaspiration is a safe and effective treatment for cerebral venous sinus thrombosis not responding to anticoagulation.
Pengukuran Kaji Dampak pada Program Pemberdayaan Petani Kopi di Tapanuli Selatan
Authors: Ekawati Rina , Prasetyo Ari Djanuar , Suesilowati Suesilowati
Published: September 2023

The article discusses the Measurement of Impact Assessment on the Coffee Farmer Empowerment Program in South Tapanuli. Data collection techniques were obtained from in-depth interviews, FGDs and direct observation of all relevant stakeholders. The data results are used as a unitary material together with the SROI calculation. SROI is currently the most generally accepted way of explaining the monetary value of the social, economic and health outcomes of an initiative. Social return on investment (SROI) is a framework used to measure and account for the value created by a program or series of initiatives, beyond financial value. In order to calculate the benefit to cost ratio, SROI uses monetary values to represent social, economic and health outcomes. For example, the 4:1 ratio in the SROI analysis shows that an investment of IDR 1 generates IDR 4 of social value. Based on the results of the SROI calculation, the SROI ratio reached 1: 2.29. This ratio means that every IDR 1 invested in the Iron Green House program is capable of producing a social impact of IDR 2.29. As a new initiative in the implementation of the TJSL program that departs from environmental issues, the number of these ratios is large enough to produce social impacts.

Keywords: Coffee Farmer Empowerment Program, Environmental Issues, Economic Outcomes, Social Impacts
Investigaciones UCA y la comunicación científica
Authors: López Ramírez Augusto Rigoberto
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 6.
Discurso inaugural Seminario de Difusión de Investigaciones UCA
Authors: Oliva de la Esperanza Andreu
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 7-10.
Análisis de la tendencia del otorgamiento de crédito en instituciones microfinancieras en El Salvador para los años 2017 al 2021
Authors: Garay Rodríguez Andrya Miriam , Landaverde Meléndez Luis Eduardo , González de Minero Sonia Jeannette , García Aguirre Rutilio Osvaldo
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 24-33.
aproximación al clima organizacional en las empresas de El Salvador bajo el contexto de la pandemia COVID-19
Authors: Vaquerano Amaya José Adán , Flores Polanco Marta Irene , Morán Valencia Marcos Antonio , Rosales de Salazar Yanina
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 38-47.
huella hídrica en la economía
Authors: López Meraris C. , Contreras Orlando E.
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 62-67.
Panorama regional
Authors: Álvarez Escobar Iliana , Montoya Cristina Saraí , Lázaro Waldir
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 89-94.
COVID-19 y violencia estructural
Authors: E. Carranza Marlon , C. López Meraris , Molina Aguilar Jorge , Alegría Gómez Federico Daniel
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 144-148.
policía como variable dependiente del territorio
Authors: López Ramírez Augusto Rigoberto
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 213-214
Satisfacción de las necesidades psicológicas básicas, indicadores de calidad de educación superior y estrategias de aprendizaje de los estudiantes de pregrado en universidades acreditadas en El Salvador
Authors: Echegoyén Calderón Edmundo Neftaly , Escobar Avelar Max Antonio , Monterrosa Hernández Harold Alejandro
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 1, 2021-2022: 225-230
Evolución de la relación entre la élite económica salvadoreña con el partido ARENA (1979-2021)
Authors: Peña Fátima
Published: September 2023

No hay resúmenes disponibles.
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 237-241.
Aprovechamiento de un material de origen vegetal para la fabricación de fibras en la industria textil salvadoreña
Authors: Jovel Zelaya José Antonio , Mejía Herrera Rafael Antonio
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 1, 2021-2022: 242-246
Desarrollo territorial y conflictos. Estudio del conflicto originado en el contexto de la administración del sistema de agua en Tacuba, Ahuachapán, durante el periodo 2004-2020
Authors: Ventura Peñate Larissa Nataly
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 247-251.
Filosofía e inspiración cristiana. Interpretación de la totalidad de la producción intelectual de Ignacio Ellacuría desde la clave de las mayorías oprimidas
Authors: Monterrosa Díaz Luis Antonio
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 252-255.
Conjuntar voces y trazar rutas
Authors: Moreno Velásquez Néstor Iván , Alfaro Amaya Norma Eunice
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 256-261.
Factores de riesgo y factores de protección vivenciados por los y las agentes de la Policía Nacional Civil en los entornos familiar, laboral, comunitario y de ciudadanía
Authors: Araujo Andrade Susana Verónica , Chávez Alfaro Sara Carmelina
Published: September 2023

No hay resúmenes disponibles. 
Investigaciones UCA, Año. 2, Vol. 2, 2021-2022: 266-270.
Behind "Time to Lead – science to accelerate the Global Goals": supporting information for the #TimeToLead campaign
Authors: Weitz Nina , Carlsen Henrik , Bennich Therese
Published: September 2023

This brief presents supporting information, methods, references and the scientific recommendations to accelerate the Global Goals, as featured in the science communications campaign “Time to Lead – science to accelerate the Global Goals”. The campaign, launched before the SDG Summit in September 2023, is backed by the recommendations described here. This brief lays out how they were derived from key synthesis reports to support decisionmakers in making sense of scientific insights and in making science-based decisions for action.