bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening and Identification of Cellulolytic Bacteria from Public Cemetery Soil
Authors: Syarifah Siti Nur , Rahayu Triastuti , Tyastuti Erma Musbita , Sidiq Yasir
Published: August 2023

Latar Belakang: Tempat pemakaman umum (TPU) merupakan tempat penguburan jenazah. Sebelum dikubur, jenzah dibungkus menggunakan kain kafan atau pakain lengkap dan terkadang dimasukkan ke dalam peti. Bahan-bahan tersebut mengandung selulosa yang menjadi substrat untuk diuraikan oleh mikroorganisme selulolitik termasuk bakteri. Eksplorasi bakteri selulolitik di TPU belum ditemukan padahal TPU menyimpan potensi jasad selulolitik. Penelitian ini bertujuan untuk mengetahui potensi selulolitik dan mengidentifikasi isolat bakteri yang berasal dari TPU. Metode: Sebanyak 36 isolat bakteri yang diuji potensi selulolitiknya sudah diisolasi dari TPU Pracimaloyo Kartasura, Sukoharjo. Seleksi bakteri selulolitik menggunakan media selektif Carboxymethyl Cellulose (CMC) yang ditetesi Congo red 0,1% sedangkan identifikasinya berdasar morfologi koloni dan pewarnaan Gram. Hasil: Penelitian ini diperoleh 1 isolat (2,78%) menunjukkan aktivitas selulolitik tinggi dengan indeks selulolitik (IS) 7 yaitu P14, 24 isolat (66,67%) dengan kategori “sedang”, 4 isolat (11,11%) dengan kategori “rendah”, dan 7 isolat (19,44%) tidak menunjukkan kemampuan selulolitik. Isolat yang positif selulolitik mempunyai warna koloni putih mengkilap, bertepi entire, elevasi raised, dan termasuk ke dalam Gram negatif berbentuk kokus. Kesimpulan: Dari hasil penelitian dapat disimpulkan bahwa tempat pemakaman umum (TPU) menyimpan bakteri selulolitik potensial.
The Influence of Inquiry Lesson Learning on Students' Scientific Reasoning Ability in Ecosystem Material
Authors: Melani Ajijah  , Aa Juhanda  , Setiono Setiono
Published: August 2023

Background: This study aims to determine the influence of applying the Inquiry Lesson learning model on the scientific reasoning abilities of Grade X students. Method: This type of research uses a quasi-experiment. The sample for this research was A total of 55 students in the science program grade 10 at one of the Madrasah Aliyah Public Schools (MAN) were involved. The instrument used is in the form of scientific reasoning ability test questions in the form of reasoned multiple-choice questions of 15 questions. The research design used is the Non-equivalent Control Group. The second instrument uses a student response questionnaire to learning using the inquiry lesson learning model, which consists of 12 questions. Results: The average N-Gain score was 0.48 in the moderate category, and the scientific reasoning abilities of students in the control class produced an average pretest score of 56.12 and a post-test average score of 70.13 with an average score of 70.13. N-Gain score of 0.32. The hypothesis test obtained a significance value of sig (2-tailed) 0.004, then H0 was rejected, and H1 was accepted. The emergence of scientific reasoning abilities of experimental class students on each indicator varies but generally has an N-Gain score in the moderate category. Student response questionnaires regarding the inquiry lesson learning model showed an average score in the excellent class (61-80). Conclusion: the conclusion in this study is that there is an increase in inquiry lesson learning on students' scientific reasoning abilities in Grade X ecosystem material.
Objek Wisata Pemandian Alam Bektiharjo Sebagai Sumber Pembelajaran Biologi
Authors: Lestari Windhiana Ayu , Cintamulya Imas
Published: August 2023

Background: Objek wisata Bektiharjo merupakan objek wisata alam yang memiliki potensi keanekaragaman hayati yang melimpah, kondisi lingkungan yang masih alami, dan interaksi sosial-ekonomi masyarakat yang beragam. Penelitian ini bertujuan untuk mendeskripsikan tentang  pemanfaatan objek wisata Bektiharjo sebagai sumber pembelajaran melalui studi tentang kelimpahan keanekaragaman hayati, kondisi kelayakan lingkungan dan kondisi sosial-ekonomi di objek wisata Bektiharjo. Metode: Penelitian ini menggunakan dekskriptif kuantitatif.  Intrumen yang digunakan dalam penelitian ini adalah lembar observasi dan angket. Lembar observasi digunakan untuk mendapatkan data kelimpahan keanekaragaman hayati dan kondisi kelayakan lingkungan objek wisata. Angket digunakan untuk mendapatkan data tentang kondisi sosial ekonomi masyarakat. Data yang terkumpul selanjutnya dianalisis secara deskriptif. Hasil: Hasil penelitian menunjukkan objek wisata Bektiharjo memiliki kelimpahan keanekaragaman hayati dalam kategori keanekaragaman tinggi, kemerataan tinggi, komunitas stabil dan dominansi jenis relative sedang, kondisi kelayakan lingkungan dikategorikan sangat baik, dan kondisi sosial ekonomi dikategorikan sangat baik. Kesimpulan: Objek wisata Bektiharjo dapat digunakan sebagai sumber  pembelajaran bagi mahasiswa pendidikan biologi. Dari hasil penelitian ini diharapkan dapat menjadi alternatif pemanfaatan objek wisata sebagai sumber pembelajaran yang dapat digunakan  oleh berbagai jenjang pendidikan.
Aralia armata (Wall.) Seem, a potential herb in treatment and complication recover therapy for stroke disease: A mini opinion and call for further research
Authors: Le Quang-Ung , Le Thi-Thu
Published: August 2023

Based on our knowledge, experience and field survey in the treatment of stroke by complementary/alternative medicine and especially the herb therapy, we briefly commented on properties of curing ischemic stroke of Aralia armata (Wall.) Seem and suggest that the future research to insightfully educidate this science opinion is necessary.

Keywords: Aralia armata (Wall.), stroke disease, ischemic stroke
To investigate phytochemical parameter, Pharmacognostical evaluation, pharmacological (anti-bacterial) activity of the extract of Euphorbia pulcherrima
Authors: Basnett Anyash , Pradhan Sushilta , Das Rajat , Sharma Chandrika
Published: August 2023

Introduction: Euphorbia pulcherrima is member of Euphorbiaceae family of medicinal plants, and it is used to cure variety of ailments which includes toothache, vomiting, fractures, severe bleeding, bruising, and hypermenorrhoea. Euphorbia pulcherrima has been found to possess a variety of chemicals, including alkaloids, steroids, terpenoids, flavonoids and reducing sugars. The review analyses its pharmacological profile, chemical component, and phytochemistry, with an emphasis on antioxidant activity, antimicrobial activity, Osteoclast activity, analgesic activity, anti-inflammatory activity, sedative activity, muscle relaxant activity, anticonvulsant activity and toxicological profile, in order to better assess the plants medicinal potential. Traditionally the latex has been employed as an anti-vomiting and toothache treatment. Aches and pains have been treated with leaf poultices. In traditional Chinese medicine it has been used it to treat fractures, severe bleeding, bruising, and hypermenorrhoea.

Methods: Due to extensive research on the pharmacological effects and active compounds of Euphorbia pulcherrima, it has a great deal of potential in modern medicine. Phyto, physicochemical standardization of dried, matured root of Euphorbia pulcherrima has been carried out in the present study. The study includes organoleptic characters along with estimation of its physicochemical parameters such as loss on drying, ash values, extractability in water and methanol.  Preliminary phytochemical screening and anti-bacterial assay has been conducted.

Conclusion: As there is not enough evidence for detailed physicochemical and phytochemical evaluation on root of Euphorbia pulcherrima is reported. The present study reveals that the selected plant extract produces antimicrobial activity with dose dependent manner. However, it needs further evaluation in clinical settings before consideration for the treatment of different diseases.

Keywords: Euphorbia pulcherrima, Phytochemicals, pharmacological activity, Physicochemical.
Comparative Study on the Efficacy of Vipadika Hara Ghrita and Taila Prepared with Go Ksheera and Arka Ksheera in the Management of Vipadika Kushta: A Case Study
Authors: Surekha O. , Srikanth Babu P. , Swaroopa A.
Published: August 2023

Objective: In Ayurveda, majority of skin diseases are dealt under broader term Kushta. As per acharya Charaka, Vipadika kushta is classified under Kshudra kushta. This can be correlated with Palmo-plantar psoriasis, which mainly effects palms and soles of a person causing cracks associated with severe pain, itching, discolouration and burning sensation. In the present study, an effort is made to compare clinical efficacy of Vipadikahara ghrita and taila prepared using go ksheera and arka ksheera in two different batches for the treatment of Vipadika kushta. Intervention: Vipadikahara ghrita & taila is a yamaka preparation that is mentioned in both charaka samhitha and ashtanga hridaya kushta chikitsa adhyaya, in the context of vipadika kushta. In this formulation ksheera is one of the ingredients, where specific type of ksheera to be used is not specified in charaka samhitha. Whereas in ashtanga hridaya commentary by Kaviraj Athrideva Gupta, usage of arka ksheera is mentioned. As specific ksheera is not mentioned in Charaka samhitha, go ksheera is taken and its effect is compared with the arka ksheera. Vipadikahara Ghrita & taila is administered externally for 15 days and changes are noted. Results: Vipadikahara ghrita & taila prepared with go ksheera helped in reducing only pain, whereas that prepared with arka ksheera reduced pain, itching, discolouration and size of the lesion. Conclusion: Hence it can be said that arka ksheera is found to be more effective in the present case study.

Keywords: Vipadika kushta, Vipadika hara ghrita & taila, Go ksheera, Arka ksheera, Palmo-plantar Psoriasis.
Cyperus rotundus commonly used drug in Unani medicine
Authors: Ahmed Reesha , Ahmed Mohammed Wasim , Khan Asma Sattar , Ahmad Anees
Published: August 2023

Herbal medicine is the oldest form of medicine known to mankind. Cyperus rotundus L. is the world worst weed native to India, which belongs to the family Cyperaceae. It is a smooth, erect, glabrous, grass like, fibrous rooted, perennial herb that grows up to 15–60 cm height, and reproduces widely through rhizomes and tubers.  Rhizomes are dark brown and woody, while stems are trigonous, green and smooth. Chemically revealed that, its consist of alkaloids, flavonoids, glycosides, phenols, tannins, steroids, starch and many novel sesquiterpenoids. In Asian countries, the rhizomes of C. rotundus, which are used as traditional folk medicine for the treatment of various ailments like amenorrhea, loss of appetite, colic, constipation, cough, diarrhea, dysentery etc.

Keyword: Cyperus rotundus, weed, rhizomes, traditional folk medicines and Disease
Evaluating the effectiveness of first-Line anti-tuberculosis in Al Dhafra Hospitals
Authors: Moetemed Mahmoud Shaaban , ALakkad Ashraf , Abdalla Hesham Abdalla
Published: August 2023

Background: Tuberculosis (TB) continues to be a significant public health issue despite extensive efforts to control it. The standard treatment for TB involves the use of first-line anti-TB drugs administered at a standard dose. However, the effectiveness of this treatment can vary between individual patients, resulting in differing cure rates.

Methodology:  The objective of this retrospective study was to assess the effectiveness and safety of first-line generic anti-TB medications administered at Liwa Hospital in the Al Dhafra Region. Data was collected from the electronic medical records of 140 TB patients admitted to Liwa Hospital from January to December 2022. The study included patients with positive acid-fast bacillus (AFB) or polymerase chain reaction (PCR) test results, indicating active TB infection. Patients resistant to first-line anti-TB medications or with lung cancer were excluded. Data collected included demographic information, length of stay conversion time, hospital admission, prescribed medications, treatment duration, and treatment outcomes.

Results: This study observed an average length of stay of 21 days for patients treated with first-line generic anti-TB medications at Liwa Hospital. Over 80% of the patients were discharged within 30 days of admission, indicating a positive response to the medications. Approximately 13% of the patients required a longer duration of treatment and were discharged between 30 and 60 days after admission. Only 5% of the patients had a prolonged stay of over 60 days, most of whom had co-morbidities or rifampicin resistance, but achieved AFB conversion within three months. The average conversion time for patients was 25 days, with over 92% achieving conversion within two months.

Conclusion: This study demonstrated the efficacy and safety of first-line generic anti-TB medications in treating TB patients at Liwa Hospital. The majority of patients responded well to the medications, leading to discharge within 30 days.

Keywords: Tuberculosis, Ethambutol, Pyrazinamide, Rifampicin, Isoniazid, First line drugs, Anti TB drugs
Formulation development and characterization of Lecarnidipine hydrochloride niosomal transdermal patches
Authors: Padmaja B. , Shobha Rani S.
Published: August 2023

The bioavailability of Lercanidipine Hydrochloride (LCP) is about 44% and half-life of the drug is about 4.6 hours. LCP due to its low therapeutic dose range of 2.5 to 20mg and substantial biotransformation in liver becomes it ideal molecule in development of transdermal therapeutic system. The primary objective of the present research work was to develop Niosomal transdermal patch (NP) of Lecarnidipine. The LCP nanoparticles were prepared by solvent evaporation method and the optimized Nanoparticles formulation has shown 225nm particle size with a polydispersity index (PDI) of 0.120. LCP patches were prepared by incorporating nanoparticles dispersion, using varying concentrations of polymers HPMC E5, HPMC 5cps, HPMC 15cps, Carbopol 734 and Sodium alginate using solvent casting techniques and further optimized by central composite design(CCD) the effect of polymer on the various physico-chemical characteristics and in-vitro drug release studies, ex-vivo skin permeation studies is studied. On the basis of in-vitro drug release and ex-vivo skin permeation studies, the formulation containing (HPMC 15cps and HPMC 5cps) has shown sustained and extended drug release over a period of 24 hrs.

Keywords: Lecarnidipine; Niosomes; Transdermal patch; Central composite Design, Controlled release; Bioavailability etc.
Prevalence of Thyroid Disorders among Somali Women of Childbearing Age at Mogadishu, Somalia
Authors: Abdiaziz Abdullahi Abdulkadir , Osman Ebar Mohamed Hassan
Published: August 2023

Background: Thyroid diseases are among the most prevalent of medical conditions, and considered the most prevalent disorders in women during their most fertile years (15 - 35 Years), and can adversely affect obstetric outcomes. The aim of the study was to determine the frequency of Thyroid dysfunction disorders among among Somali Women of Childbearing Age at Mogadishu, Somalia.

Materials and methods: This study was descriptive cross-sectional Hospital-based study conducted at Jazeera University Hospital, Mogadishu, Somalia during the period of December 2022 to April 2023. a total of 100 subjects were included in the study. A  total of  five  ml  of  whole  blood  was  collected  from each  participant into sterile plain  containers  for  thyroid hormones estimation. Estimation of thyroid hormones was done by using ELISA machine (Maglumi 800). The data was gathered using per-designed structural questionnaire and the SPSS 26.0 statistical software (SPSS Inc., USA) was used for statistical analysis.

Results: The age of the study population ranges from 15–40 years with a mean age of 25.4 ± 8.11 years. There was insignificant correlation between the age and the frequency of thyroid dysfunction with P-value of 0.453. According to their BMI maximum respondents 42 (42%) were grouped under normal BMI, 40 (40%) respondents were over weighted, 2 (2%) of the respondents were grouped underweight and 16 (16%) were obese. The family history of thyroid dysfunction was found in 51% of the study population where 49% of them had no family history of thyroid dysfunction. For the laboratory diagnosis, maximum respondents were Euthyroid 87 (87%) followed by 8(8%) of respondents, were hyperthyroid and 5(5%) respondents had hypothyroid.

Conclusion: This study concluded that there is a slightly higher frequency of thyroid dysfunction disorders among Somali Women of Childbearing Age.

Keywords: Thyroid dysfunction, hyperthyrodism, hypothyrodism, childbearing age
Effect of Acne Vulgaris and its Impact on Quality of Life of Adolescents in Bengaluru
Authors: Shabnam Shabnam , Rashid Basharat , Mannan Mohd Nazir , Rahman Anisur
Published: August 2023

Background and Objective: Acne vulgaris is a chronic condition affecting more than 85% of adolescents and young adults. This study was conducted to assess the prevalence of acne vulgaris and its impact on quality of life (QoL) and to study socio-demographic factors, family history and lifestyle among the selected schools at Jalahalli area in Bengaluru. Materials and Methods: This study was a descriptive cross sectional school based study and 200 subjects were included. Predesigned, questionnaire to assess socio-demographic profile and QoL and symptoms of acne vulgaris were administered to the participants fulfilling inclusion criteria. Data were obtained by using different methods such as Global Acne Grading System (GAGS), Cardiff Acne Disability Index and Children’s Dermatology Life Quality Index/Dermatology Life Quality Index (CDLQI/DLQI) respectively. SPSS 18.0 software was used for data analysis. Results: Findings showed that Acne prevalence was 87% affecting both sexes. Self-reported mild acne was present in 85.1% and moderate severe acne in 14.9% of the adolescents. The mean age of the subjects was 14.78 years, with 52.5% females and 47.5% males. A strong relation was found between the severity of acne and QoL (p<0.001). Heredity was correlated with acne and its severity was significant. Conclusion: Acne affects the QoL of an adolescent, and the impact is proportional to the severity of acne. Severe acne is associated with a greater effect on QoL. Evaluation of QoL in such patients may greatly help in the better management of acne, hence improving their quality of life.

Keywords: Acne vulgaris; Adolescent; Quality of life; GAGS; CDLQI; DLQI.
Effect of Gallic Acid Treatment on Hepatic Tissue in Ischemia-Reperfusion
Authors: Durgun Cemalettin , Deveci Engin
Published: August 2023

Aim: Hepatic IR occurs in many clinical conditions such as liver injury, liver hemorrhage and shock, surgical resection, and transplantation. In our study, it is aimed to investigate whether gallic acid (GA) can be used for hepatoprotective purposes, histopathologically.

Study Desıgn: 24 Wistar albino male rats were divided into 3 groups (n:8). Surgical procedures were done under general anesthesia. A 4 cm midline abdominal incision were opened to observe hepatoduodenal ligament.  The portal vein and hepatic artery was closed with a rubber band and silk suture, and ischemia was performed for 60 minutes. The suture was opened and hepatic reperfusion was performed for 6 hours. 50 mg/kg Gallic Acid was administered to the rats in this group by intraperitoneal route once a day for 14 days.

Results: Normal histology of lvier was observed with regular vena centralis, endothelial cells, hepatocytes and sinusoid. In IR group, blood vessels were dilated and congested with cell infiltrations. Hepatocytes were degenerated with irregular sinusoides and hyperplasic Kupfer cells. IR+GA group, mononuclear cell infiltration continued with thickening of the basement membrane of the vessels. Vacuolated hepatocyte was observed. GA treatment alleviasted the pathologies occurred due to IR injury.

Conclusion: It was thought that the cellular damage in the inflammation signal, which started as a result of the cessation of blood flow after ischemia-reperfusion injury, affects the classical lobule of the liver especially around the vena, and may cause necrotic changes by increasing cell apoptosis due to functional nutritional deficiency.

Keywords: liver, ischemia, reperfusion, gallic acid, histology
Phytochemistry and Antiperoxidative Potential of Cannabis sativa L. Leaves Methanol Extracts: An In Vitro Study
Authors: Saxena Anjani , Puranik Nitin
Published: August 2023

Aim: Present study aimed to demonstrate the preliminary phytochemical composition, antioxidant and in vitro protective potential of the methanolic extract of Cannabis sativa L.

Study Design: A methanolic extract of Cannabis sativa L. leaves was prepared and assessed at the in vitro level for its preliminary phytochemical screening and antiperoxidative potentials by using the DPPH radical reduction assay, lipid peroxidation inhibitory activity, protein carbonyl inhibitory potential in glycated bovine serum albumin, and enzyme antioxidant activity in a goat liver homogenate system exposed to hydrogen peroxide as oxidant molecule.

Results: The methanolic extract of Cannabis sativa L. leaf contained a diverse range of phytoconstituents, including alkaloids, flavonoids, tannins, terpenoids, and saponins. Upon quantitative analysis, the methanolic extract of  C. sativa L. reflected 50 ± 0.013 µg quercetin equivalent / mg of extract according to the querecetin standard graph, while 28.03 ± 0.024 % alkaloid content was retrieved after quantification.

Conclusion: We suggest that, upon tested on all in vitro antioxidant parameters; the leaf methanolic extract of Cannabis sativa L. demonstrated potent antioxidant and protective activity.

Keywords: Cannabis sativa L., Antioxidant, in vitro, DPPH, LPO, Protein carbonyl, peroxidative potential
Management of risk factors and pharmacological therapy in oral pemphigus vulgaris: A Case Report
Authors: Nuraeny Nanan , Setiadhi Riani
Published: August 2023

Introduction: The incidence of pemphigus vulgaris is rare. It often occurs in middle age and the elderly or in the 4th to 5th decades. Women experience it more often than men. Pemphigus vulgaris predominates in patients of Ashkenazi Jewish, Asian or Mediterranean descent. The etiology of pemphigus vulgaris remains unclear, but it can be triggered by several risk factors, such as drugs, radiation, surgery, and some foods. This case report aims to describe a case of oral pemphigus vulgaris caused by stress and food and its management. Case: a 45-year-old woman who was hospitalized at Dr. Hasan Sadikin hospital referred from Dermatology and Venerology department to Oral Medicine department with diagnosis pemphigus vulgaris. The risk factors were emotional stress and food preservated. Pharmacology therapy including steroids, anti-fungal, and vitamins. Discussion: The management of this patient was carried out by a multidisciplinary team, dermatologist collaborate with oral medicine specialist to support comprehensive therapy. Identification and controlling emotional stress and cessation of food which was suspected as the cause, were the important aspect as an addition to the given pharmacological therapy led to significant improvement of oral pemphigus vulgaris. Conclusion: Oral pemphigus vulgaris as a chronic autoimmune disease can be cured if the risk factors can be controlled and close monitoring of pharmacological therapy can be carried out by a team.

Keywords: pharmacology, risk factor, oral pemphigus vulgaris
First Gnathia sp. (Gnathiidae) Infestation on Labrus viridis (Labridae) in Türkiye
Authors: Kumaş Kaan , Dinçtürk Ezgi , Tanrıkul Tevfik Tansel
Published: August 2023

Gnathiids are ectoparasites of elasmobranchs and teleosts. The adult stage of gnathiids is free-living but has a blood-sucking parasitic form called praniza larvae. Gnathiid praniza infestations have been previously reported in numerous species of fish. In the current study, Labrus viridis collected from İzmir Bay, Aegean Sea, was examined for parasite infestation. Gnathia sp. was found predominantly in the gills and mouth cavity of fish with a 58.3% prevalence. The samples were collected with fine forceps from the host and preserved in 70% ethanol and 10% formaldehyde solution for observation with a light microscope and scanning electron microscopy to identify parasites. Red and green-blue pranizas were detected, and the hindgut of pranizas showed differences depending on attachment location of the host.
Post-COVID-19 Higher Learning: Towards Telagogy, A Web-Based Learning Experience
Authors: Pitso Teboho
Published: August 2023

Institutes of higher education (IHEs) have to consider benefits of remote learning post-pandemic. Retrogression to physical contact is counterproductive. The hasty implementation of remote learning during the pandemic deprived IHEs of opportunities to efficiently enact and theorise about it. Post-pandemic, IHEs have opportunities to theorise about remote learning hence the questions; a) what type of learning emerges when asynchronous and technology-as-essence framework undergirds students learning? b) What benefits accrue when chat-Generative Pre-training Transformer (chat-GPT) is infused into students learning? Use of synchronous learning and technology-as-utility framework to underpin remote learning during the pandemic was intended to retain most of physical contact learning traditions. Teachers and students met synchronously and simultaneously online for learning to occur. IHEs safeguarded their operational efficiency to minimise the disruptive nature of remote learning. The purpose of the study was to theoretically examine effects of asynchronous learning and “technology-as-essence framework on students learning. Asynchronous learning occurs when students registered on the same course learn online on their own schedule without any real-time interactions with teachers. This phenomenon occurs when remote learning develops through technological advances that, beyond 2030, would most likely stream educational courses similar to Netflix. One such technological advance is chat-GPT. A study was undertaken to better understand it. 15 multi-disciplinary advanced undergraduates tested out chat-GPT on their assignments and a concrete problem. Chat-GPT lessened the time of doing assignments and improves students’ problem solving abilities. AI systems advances have a positive effect on students learning. The study addresses the positive impact of asynchronous learning and advances in technology on IHEs.
The Improvement of ASM GaN Model Applied to Multi-temperature Bias in AlGaN/GaN HEMT Devices
Authors: Lei Yue , Shi Tianxiang , Wang Yan
Published: August 2023

This article improves the mobility part of the ASM GaN model, and
provides the corresponding multi-temperature DC parameter extraction
process based on the existing ASM GaN model, in order to address the
accuracy of the ASM GaN model at different working environment
temperatures in AlGaN/GaN HEMT Devices. In addition, this article
validates the accuracy of the improved ASM model through parameter
fitting. Compared with previous models, the modified model has higher
accuracy and fewer temperature parameter values in the parameter
extraction process at multiple temperatures.
Colitis cystica profunda: a two-patient case series
Authors: jiang qing ling , Qin Si , Zhang Han , Liu Guangjian
Published: August 2023

Colitis cystica profunda (CCP) is a rare benign disease characterized by
mucus-filled cysts in the submucosa, sometimes similar to malignant
tumors. Endoscopic, radiological and even histological examinations are
not highly specific, which can easily lead to missed diagnosis and
misdiagnosis, resulting in unnecessary radical surgical resection. In
this report, we present
Lichen fallback food in nonhuman primates at high altitudes, a unique ecological adaptation and evolutionary development
Authors: Pan Hao , Hou Rong , Zhang He , Huang Zhipang , Li Yanpeng , Cui Liangwei , Xiao Wen
Published: August 2023

Fallback foods (FBF), classified into staple and filler types, are
low-quality food resources chosen by animals due to a shortage of
preferred food during a specific period. The selection of lichens as FBF
for Yunnan snub-nosed monkeys (Rhinopithecus bieti) represents a unique
ecological adaptation and evolutionary development in the animal
kingdom. This study investigates the yearly dietary selection of five R.
bieti groups to address the issues and elucidate the nutritional value
and ecological selection of lichens for this monkey species, which
resides at the highest altitude among nonhuman primates. The results
indicate that the consumed lichens serve as the staple FBF. Two main
lichen species taken by the monkeys are Bryoria spp. and Usnea
longissimi, with Bryoria spp. being the primary choice (67.25 ± 12.20%
compared to 15.79 ± 11.66% from U. longissimi). Bryoria spp. provides a
higher level of digestible fiber (NDF) and a lower level of tannin, fat,
ADF, and energy compared to U. longissimi, which offers higher
availability. Lichens are the dominant food and nutritional resource for
the monkey species during the dry season, while they serve as a primary
food source rather than a nutritional resource during the wet season.
Therefore, they compensate for nutrients from other food types, such as
fruits, seeds, and leaves. Compared to other Asian colobine
counterparts, this species consumes the highest amount of lichens but
the lowest proportions of leaves, flowers, and seeds. This dietary
pattern demonstrates a specific type of ecological selection and
evolutionary development during the Quaternary. The biomass of lichens
in the monkeys’ habitat has significantly decreased due to environmental
degradation. This study also provides evidence and information to
develop or amend conservation strategies and guidelines for the dietary
management of captive Yunnan snub-nosed monkeys.
Design of an effective air electrode using highly porous carbon-aerogel on carbon cloth for oxygen intake towards improved reaction kinetics of aluminum-air battery
Authors: Pandey Anant , Rani Bharti , Sharma Minakshi , Yadav Jitendra Kumar , Saini Priyanka , Shalu * , Dixit Ambesh
Published: August 2023

One of the greatest alternatives to Li-ion batteries is an Al-air
battery. The aluminium (Al) is more effective as a battery because of
its viability and nontoxicity. The design of cell and electrode stacking
affect the performance of Al-air battery. The present study focuses on
designing an efficient air cathode host to lengthen the battery’s
lifespan using highly porous carbon aerogel. Initially, the carbon
aerogel (CA) material is synthesized using sol-gel polymerization
process and characterized using XRD, SEM, and BET. The synthesized CA is
used to fabricate the electrode stacking using the in-house-built Al-air
cell. The performance of carbon aerogel coated on carbon cloth as air
cathode has been evaluated using a galvanostatic discharge of the
assembly at different current rates, and the specific capacity is
recorded. The highest specific capacity observed is ~
683 mAh g-1 at 2.551 mA cm current density. The
acquired results demonstrate the superiority of the present electrodes
material compared to currently used air electrode. The improved
electrochemical stability and the robust pore network in CA allow oxygen
to pass through the cathode end for chemical reaction. Overall, this
enhances kinetics and makes the interactions between oxygen and aluminum
to generate higher current because of relatively faster chemical
reaction.
Topical treatment of psoriatic skin with methotrexate cream: a clinical, pharmacokinetic, and histological study
Authors: Bjerring P , Beck HI , Zachariae H , Søgaard H.
Published: August 2023

Five patients were treated with either 0.25% methotrexate cream or placebo in a double blind trial. The evaluation showed no clinical or histological effect although the drug was absorbed from the skin. Methotrexate (MTX) accumulated in locally treated psoriasis plaques as well as in untreated plaques. The psoriatic skin concentrations were increased by a factor of 119 and 4, respectively. This observation is discussed in relation to the possible role of action of methotrexate in psoriasis. We suggest that methotrexate inhibits the chemotaxis of neutrophil leukocytes systemically and not primarily in the skin, thereby preventing development of the early stages in the psoriatic lesions.
The Relationship Between Fear, Loneliness, and Depression Among University Students: A Structural Equation Model
Authors: Abu Shind Yousef Abdelqader , Al-Bahrani Muna Abdullah , Alkharusi Hussain Ali
Published: August 2023

The aim of this study was to test the causal relationship among fear of Covid-19, loneliness, and depression from Covid-19. The study sample consisted of 605 undergraduate students recruited from a public university. They completed three scales: fear of Covid-19, depression from Covid-19, and loneliness. The results revealed a good fit index for the proposed path model. The fear of Covid-19 predicted two types of loneliness emotional and social negatively. A positive association between depression and emotional as well as social loneliness was found. A total of 43% of the variance in depression was explained by loneliness.  Depression was potentially a mediating factor between a fear of pandemic and the feeling of loneliness. A counseling intervention can be designed based on these results.
The Aftermath Implications of Teenage Pregnancy on the Girl Child Education
Authors: Odiri Onoshakpokaiye E , Anthonia Oboawharhe Eloho
Published: August 2023

The aim of the study is to investigate: i) impact of teenage pregnancy on the girl child attending government secondary schools ii) the level of academic accomplishment of the pregnant teenagers at the public secondary schools. The research design for this study was a descriptive survey. The study population made up of 800 teen mothers. A sample of 200 teen mothers in Ethiope East Local Government Area of Delta State, Nigeria, who had dropped out of secondary school as a result of teen pregnancies, was chosen through simple random sampling. The instrument utilized to collect the data was questionnaire which was administered to the participants, validated by three experts and its reliability was tested using Cronbach alpha which yielded 0.68. The participants were also interviewed. The data collected were analyzed using simple percentages. The results showed that young women who became pregnant while in school face a variety of difficulties, including early marriage, rejection by the family, disassociation from former classmates, social isolation, frequent absences following pregnancies, poor academic performance, and reasons for dropping out of school. The findings revealed that teen pregnancies affect the relationship of the girl child, family and peer group and also have an impact on young girls' academic performance in public secondary schools. We deduced from the literature review that adolescent pregnancy is a widespread problem that demands attention due to its effects on the education of girls. Some recommendations were also made.
MANAGEMENT FAMILY COMMUNICATION PATTERNS OF FEMALE TEACHERS AT STATE SECONDARY SCHOOL WEST JAVA
Authors: Ramdan Deden
Published: August 2023

This study entitled “Family Communication Patterns Of Female Teachers At State Secondary School 15 Bandung City District West Java Province”. Female teachers who become informants are those whor are married and have children. The purpose of this study was to find out how or the pattern of communication carried out by a female teachers in childcare. And which family communication pattern will they use in parenting. The method used in this study is a qualitative research method with the theory of family communication pattern. With qualitative methods, researchers can obtain data using in-depth interview techniques so that the it is hoped that the data obtained will be able to complement and produce comprehensive qualitative descriptive data. The results obtained from this study are the communication patters that exist between female teachers and their families, where a pluralistic pattern is chosen from the four patterns contained in the concept of family communication, as a result of this entire research.
CUSTOMER SATISFACTION SURVEYS ON ORGANIZATION OF INDONESIAN FOOD AND DRUG AUTHORITY
Authors: Pitaloka Endang , Avianti Widiya
Published: August 2023

Indonesian Food And Drug Authority (BPOM) has the task of carrying out the preparation and implementation of policies, the preparation of norms, standards, procedures, criteria, the implementation of technical guidance and supervision. This study analyzes the Performance and Level of Service Importance (Importance Performance Analysis-IPA) in BPOM, in Quadrant I shows the highest service performance. In this quadrant there are indicators of Officer Cost and Behavior. On the cost indicator, it does not involve too many officers. Payment of services can be made by customers online with a virtual account. Customers assessing cost indicators are important aspects of the service and the assessment of its satisfactory performance "Good". This means that BPOM service products are in accordance with customer needs.
FEASIBILITY ANALYSIS OF COFFEE PROCESSING BUSINESS IN CIJAMBU SUMEDANG
Authors: Indrayani Rina , Suwarman Herman , Aidil Danny
Published: August 2023

The increase of coffee consumption encourage a small scale enterprise, Cijambe Coffee to identify the current business performance to face the challenge. The research purposes are 1) to evaluate the feasibility of Cijambe Coffee business, 2) To interpreted the evaluation result in recommendation that help enterprise to decide the strategy. The research method is quantities and qualitative approach. The evaluation results: 1) the product has distinctive quality, 2) Technical factor is feasible in terms of producing good quality, 3) financially feasible that is proven by the parameters: NPV (IDR 2,350,000), PP (2.9 years), IRR (27.88%), and unit BEP (169.23 units), and the value of BEP ( Rp. 5,076,923.07), 4) Recommended strategy are : expanding market and production capacity with accurate forcast and strategy; the shifting of B to C into B to B market strategy or mix of both; acquiring business partners with good bargain and productive resources.
THE EFFECT OF CELEBRITY ENDORSER AND PRICES ON THE JGLOW PRODUCT PURCHASE DECISION PROCESS
Authors: Koesworodjati Yudhi , Sapira Meita
Published: August 2023

This research was conducted based on data on the increasing contribution of the creative industry sub-sector of Bandung City to PDRB in 2018 to 2020. The research method used is descriptive and verification method with a total sample of 100 respondents. The data analysis method used is multiple linear regression analysis, multiple correlation and coefficient of determination. The results showed that there was a positive and significant influence between celebrity endorser and price on the purchasing decision process. The magnitude of the influence of celebrity endorser and price on the purchasing decision process simultaneously is 53.4% and the remaining 46.6% is influenced by other variables not examined. Partially the magnitude of the influence of celebrity endorsers on the purchasing decision process is 9.4% and the influence of price on the purchasing decision process is 44%, so it can be concluded that the price has the greatest influence on the purchasing decision process.
Increasing of oral health education knowledge after intervention psychoeducation methods in adolescents
Authors: Yubiliana Gilang , Kusumah Salsabila Putri , Abdurrochman Andri
Published: August 2023

ABSTRACT Introduction: The technique of imparting knowledge and understanding known as "psychoeducation" combines particular knowledge with media to communicate knowledge, is professionally provided, and integrates educational and psychotherapy treatments. Given the close connection between oral health and general health, oral health should not be neglected during the pandemic. Through the use of psychoeducational techniques, dental health issues can be prevented and overcome. The objective of this study is to analyze the increase in oral health education knowledge before and after intervention using psychoeducation methods in adolescents. Methods: This research was conducted using the one group pretest-posttest design. A study sample was obtained using the Slovin formula after a population was sampled using purposive sampling. The following requirements must be met in order for students to be included in the sample: they must be concerned about their oral health, be open to participating in psychoeducation webinars, and agree to participate as research subjects. There were 86 responses in the sample. By providing a questionnaire before (pretest) and after (posttest) the intervention in oral health education using psychoeducation method, the increase in knowledge can be measured. Results: The results of the Wilcoxon signed rank test with an alpha significance of 0.05 and Asymp. Sig (two-tailed) p = 0.001 (p < 0.05), or the knowledge factors of research respondents. This revealed significant improvements in respondents' knowledge between the pre- and post-intervention periods. Conclusion: The intervention of psychoeducational methods regarding oral health education could increase knowledge in adolescents. Psychoeducational methods can help adolescents learn more about oral health.
Indústria de produtos para a saúde e os loci de suas competências científicas e tecnológicas
Authors: Miranda Caroline , Hasenclever Lia
Published: August 2023

A indústria de produtos para a saúde é intensiva em capital e em inovações e necessita de um ambiente institucional e empresarial favorável para se desenvolver, bem como de competências científicas e tecnológicas, que muitas vezes não se encontram disponíveis. O objetivo do artigo é realizar a identificação dos loci das competências científicas e tecnológicas do setor de equipamentos e materiais médicos, hospitalares, odontológicos e de diagnóstico no território brasileiro e discutir, a partir da literatura, como se deu o desenvolvimento de três aglomerações produtivas neste setor. Foi adotada a abordagem de sistema de inovação e seus conceitos derivados: arranjos produtivos locais e relação universidade-empresa. Os resultados obtidos apontam que, no caso da análise das competências científicas e tecnológicas, há uma aglomeração de grupos de pesquisas e empresas nas regiões Sudeste e Sul do país. Já no que se refere aos APLs, os resultados apontam que a articulação foi proposta pelas empresas, embora já houvesse interação entre empresas e instituições antes mesmo da formação dos APLs, e que esses APLs envolviam mais de 20 instituições e empresas. Os resultados obtidos ressaltam ainda  a importância da interação entre empresas e instituições de pesquisa localizadas em uma mesma região para incentivar o crescimento da indústria e a geração de inovações para o mercado. Assim, conclui-se que ainda há muito a se desenvolver neste setor no Brasil.
Palavras-chave: APL. EMHO. Campo Mourão. Pelotas. Ribeirão Preto.
Prevenção ao suicídio e os objetivos de desenvolvimento sustentável
Authors: Stavizki Junior Carlos , Etges Virginia Elisabeta
Published: August 2023

A problemática da prevenção ao suicídio ganhou destaque nas últimas décadas, após a Organização Mundial da Saúde (OMS) classificar a morte autoprovocada como “problema de saúde pública global”, no início do século XXI. O Brasil assumiu compromissos e aderiu às metas de redução da taxa social de suicídios planejadas por instituições internacionais, sendo a mais recente os Objetivos de Desenvolvimento Sustentável (ODS), incluídos na Agenda 2030 da Organização das Nações Unidas (ONU). Neste trabalho, discute-se as metas dos ODS nº 3, “Saúde e Bem-estar”, apresentando seus principais indicadores e analisando os dados relacionados à meta 3.4, que almeja reduzir o número de mortes prematuras, através da promoção de saúde mental e bem-estar. Trata-se de uma pesquisa documental e de natureza aplicada, sustentada por dados quantitativos e revisão crítica da literatura. Analisou-se que o Brasil possui políticas públicas que contribuem com os ODS, porém seus indicadores sociais e de saúde demonstram uma tendência negativa para o bem-estar social, acompanhado de aumento dos índices de suicídio.
Palavras-chave: Saúde Mental. Bem-estar. Políticas Públicas. ODS.
Optimization of Drying Parameters in the Production of Purple Carrot Puree Powder
Authors: DEMİRCAN Bahar , VELİOĞLU Yakup Sedat
Published: August 2023

Purple carrots are an important source of phenolic compounds and spray drying is the most advantageous method to make purple carrots more stable. Optimization analysis was carried out to determine the effects of inlet temperature, pump rate, and maltodextrin concentration on the process yield, antioxidant activity, total phenolic and anthocyanin content in the purple carrot puree powder. The optimum drying parameters obtained by maximizing the dependent variables (desirability=0.809) were determined as 16.51% (w/v) maltodextrin concentration, 180.16°C inlet temperature, and 30.39% pump rate. Process yield was 83.64%. Under optimum conditions, the dependent variables were 81.20% DPPH scavenging antioxidant activity, 5332.87 ppm total phenolic content as gallic acid equivalent, and 449.71 ppm total anthocyanin content as cyanidin-3-glucoside, and results indicated that they were preserved at 92.66, 90.43 and 83.79%, respectively.
In Vitro Antioxidant and Enzyme Inhibitory Activities of Walnut Male Flowers
Authors: AYDIN Ebru
Published: August 2023

Walnut (Juglans regia L.) male flowers are known for their high phenolic content and associated health benefits, including anti-hypoxic, antihaemolytic, anti-inflammatory, antidepressant, and antioxidant activities. This study represents the first investigation of the inhibitory effects of walnut male flower extract on α-amylase and α-glucosidase enzymes, employing HPAE-PAD (High-Performance Anion-Exchange Chromatography with Pulsed Amperometric Detection). The inhibitory potential of the extract was compared to that of acarbose, a chemical drug commonly used for this purpose. Furthermore, the antioxidant activity of the extract was also evaluated. The extract demonstrated significant inhibition of α-amylase and α-glucosidase, with half maximal inhibitory concentration (IC50) values of 1.507 mg/mL and 0.803 mg/mL, respectively. In contrast, acarbose exhibited IC50 values of 1.031 mg/mL and 0.985 mg/mL for α-amylase and α-glucosidase, respectively. Although the walnut male flower showed greater inhibition of α-glucosidase than acarbose, acarbose exhibited stronger inhibition of α-amylase activity than walnut male flowers. The extract exhibited a DPPH (1,1-Diphenyl-2-picrylhydrazyl radical) free radical scavenging activity, with an IC50 value of 19.51 µg/mL. Additionally, the total phenolic content of 277 mg GAE (gallic acid equivalent)/g dry weight (dw) was determined in the extract. These results may highlight the potential of walnut male flowers as a novel enzyme inhibitor for managing type 2 diabetes mellitus. The findings of this study could provide valuable insights for further investigation into the potential applications of walnut male flowers in the food and pharmaceutical industries.