bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of SNS Usage Behavior on Cultural Adaptation: Focusing on Foreign Students from Minority Countries
Authors:   The Korean Society of Culture and Convergence, Choi Jeongyeol
Published: November 2023

This study analyzed the effect of SNS usage behavior on adaptation to Korean culture for foreign students of minority nationalities residing in Korea. To this end, SNS usage behavior (SNS usage time, SNS preference orientation, SNS motivation), cultural adaptation level (psychological, socio-cultural), and general characteristics(gender, marital status, length of residence, Korean language level, age, economic level, nationality) was surveyed, and empirical analysis was conducted using the data of the final 105 people. As a result of the analysis, it was found that the use of SNS had a positive effect on Korean cultural adaptation, especially on psychological adaptation. On the other hand, the effect of SNS preference orientation(SNS preference medium, preference person, and preference language) was not statistically significant. As for general characteristics, the higher the level of Korean language and the longer the residence period, the better the cultural adaptation.
A Study on Metaverse Model Construction for Safety Management Digital Transformation
Authors:   The Korean Society of Culture and Convergence, Jeong Sanghun , Chang Changsoo , Eom Byeongju , Kim Kangrae , Jeong Haejun
Published: November 2023

Metaverse is a digital platform that operates in a virtual space and is being applied to various fields as non-face-to-face activities increase due to COVID-19. This study proposes a method of using a metaverse to overcome the shortcomings of the existing road training method and to make safety management DX (Digital Transformation). Among the metaverse platforms, Gathertown is a digital platform that can be customized, communicated, and collaborated, and can work in a virtual space. Using these features of Gathertown, tools and equipment necessary for safety management work were implemented in the metaverse, and scenarios for safety education and emergency training were organized. The results of this study proved that the establishment of safety management DX is a useful tool to increase the efficiency and effectiveness of safety management work.
A Study on Yun Dong-ju's Poetry through Bibliographic Data Analysis 4
Authors:   The Korean Society of Culture and Convergence, Kim Hyung-tae
Published: November 2023

The purpose of this paper is to shed new light on Yun Dong-ju's life and poetry by analyzing the “Chosun Ilbo”, “Boy”, and “Moon woo”, which are important bibliographic data during Yun Dong-ju's Yeonhui Technical College. This paper examined Yun Dong-ju's “An impression paiting of My younger Brother” published in the “Chosun Ilbo” ‘Student Page’ in October 1938, in connection with the post-impressionism art and discussed Yun Dong-ju's interest in the modern succession of traditional Chosun Dynasty culture. In addition, Yun Dong-ju met Yun Seok-joong when he released ‘A Mountain Cry’ in “Boy” in March 1939, and Yun Seok-joong will publish four of Yun Dong-ju's poetry ‘A Mountain Cry’, ‘Sunlight and Wind’, ‘Sunflower Face’ and ‘Baby Dawn’ in the magazine “A young student” after liberation, and three except ‘A mountain cry’ were released for the first time since liberation. In June 1941, Yun Dong-ju announces “A New Way” and “Self-potrait in a Well” in the magazine “Moon woo” published by Yeonhui Technical College, which shows the will of Yeonhui Technical College students to open a new era based on our traditional culture despite the harsh reality of Japan's Imperial New Folkization Policy.
Virtual ‘Writing’ in the Repetition of ‘Kubo’
Authors:   The Korean Society of Culture and Convergence, Heo Jinhyuk
Published: November 2023

This study compares and analyzes the film Sisyphus’s vacation and the novel A Day in the Life of Kubo the Novelist. The film repeats the character 'Kubo', while actualizing the writing itself. The film evokes the object of Kubo as a novelist and of his writing. However, the attempt to find writing again in the novel fails. Kubo in the novel is unable to write. Writing is an absent object in the novel. In the novel, Kubo pretends the social identity of a novelist as a response to the absence of writing. Therefore, the object that the film repeats is not the novel itself, but another object as a third point of reference. A novel in which writing exists is assumed. Writing as a virtual object is not inherent in the novel, but is retroactively defined through its repetition in the film. Virtual writing is only revealed through repetition, it can be a way of reading the novel through the film.
The Effects of Multiculutral Acceptance of Thai K-POP Fans on K-POP Attitude and Consumption
Authors:   The Korean Society of Culture and Convergence, Yun Yeongsam
Published: November 2023

This study explored the influence of multicultural acceptability of Thai K-POP fans on K-POP attitude and consumption. Therefore, the study subjects were selected as students who had participated in the K-POP Academy hosted by the Korean Cultural Center in Thailand at least once. As a result of the study, among the multicultural acceptability of Thai students who participated in the K-POP Academy, rejection showed a positive effect on K-POP playfulness, and openness and initiative had a positive effect on both K-POP playfulness and K-POP attitude. In addition, it was found that Thai students' K-POP playfulness and K-POP attitude had no influence on K-POP purchase intention. Finally, it was confirmed that multicultural acceptability of Thai students who participated in the K-POP Academy had an indirect effect on K-POP purchase intention. This study can provide Korean government agencies and the K-POP industry with implications for K-POP policy direction and K-POP marketing strategy in the Thai market, and also helps the working staff of the Korean Cultural Center in Thailand to plan a K-POP Academy.
Analysis of Stakeholders related to Policy Conflicts Based on Mendelow Matrix
Authors:   The Korean Society of Culture and Convergence, Kim DaeJoong
Published: November 2023

The purpose of this study is to explore an applicable model for stakeholder analysis from a policy conflict perspective. To explore the model applicable to stakeholders, we applied the Mendelow Matrix model that shows the dynamics between stakeholders, which have been commonly used in stakeholder analysis in organization and business administration, on a two-dimensional plane of power (influence) and interest. As an application case, the structure, change, and resolution process of the conflict among stakeholders by management method were identified as a result of examining the possibility of exploration for stakeholders in the conflict of spent nuclear fuel management method. The implications of this study can be found in the possibility of methodological utilization and the possibility of use as a supplementary tool for conflict impact assessment.
A Study on Local Government Support Policies for Labor-management Coexistence of Local Manufacturing SMEs: Focusing on Working Environment and Employee Welfare of Manufacturing SMEs and Government Support Policies for the SMEs in Ulju-gun, Ulsan, South Korea
Authors:   The Korean Society of Culture and Convergence, Doh Soogwan
Published: November 2023

The purpose of this paper is to analyze the working environment and employee welfare level of manufacturing SMEs and government support policies for the SMEs in Ulju-gun, Ulsan and to explore local government support policies for labor-management coexistence of local manufacturing SMEs. Main results of this study suggest government support policies for functional reinforcement within the workplace, expansion and diversification of employee welfare, and simplification and efficiency of government support projects application process for labor-management coexistence of local manufacturing SMEs.
Development and Effect of Imagery Rescriping Program to Relieve Post-traumatic Stress Symptoms and Promote Post-traumatic Growth of Adolescent Bully-victims
Authors:   The Korean Society of Culture and Convergence, Heo Surin , Kim Keun-Hyang
Published: November 2023

The purpose of this study is to discuss the effect of Imagery rescriping program on alleviating post-traumatic stress(PTSD) symptoms and promoting post-traumatic growth(PTG) in adolescents affected by group bullying. For this purpose, 24 adolescent with PTSD symptoms were selected through group bullying, and 12 were randomly assigned to treatment group and waiting control group. During the experiment, two people were eliminated from the treatment group, and data from 10 treatment groups and 12 waiting control groups were analyzed. As a result, the program was found to have a significant effect on alleviating PTSD symptoms and promoting PTG(self-opening, deliberate rumination). In subsequent studies, it will be necessary to design a later test to gauge the long-term effect of the mental rewriting. Also, it will be necessary to find out if there is a difference in effect depending on the severity of the symptoms.
Effects of Insulin Resistance on Cardiocerebrovascular Disease: Effects of Insulin Resistance
Authors:   The Korean Society of Culture and Convergence, Choi Myeongsik
Published: November 2023

Recently, insulin resistance has been caused by the imbalance between energy intake and calories consumed, and the prevalence of cardiocerebrovascular disease is increasing. Therefore, it is intended to understand how physical activity, nutrients, and food group intake affect insulin resistance, and to examine the association with cardiocerebrovascular disease. This study used data from the 3rd year of the 6th National Health and Nutrition Examination Survey, and a total of 740 people with insulin resistance were the final subjects of analysis. To investigate the relationship between insulin resistance and cardiovascular disease, chi-square teat, t-test, and logistic regression were performed. final analysis targets. As a result, it was found that in those with insulin resistance, high blood pressure increased 2.31 times, dyslipidemia increased 1.76 times, and stroke increased 1.72 times. We hope that it will be used as basic data to understand the relationship between insulin resistance and cardiovascular disease and to find different ways to minimize the risk.
Exploring Thriving Experiences of Four-Year College and University Students by Community Cultural Wealth in the Gyeonggi-Inchon Area
Authors:   The Korean Society of Culture and Convergence, Lee SeungYun
Published: November 2023

This study is to examine the thriving experiences of four-year college students through the utilization of community cultural wealth. By a grounded theory, we investigate students who attend three different universities in the Gyeonggi-incheon region, who are recognized successful by their college and university staff members. All the participants possessed both anticipatory and navigational capitals and with a few exceptions had a relatively clear vision for their career paths. The majority of the research participants are however in psychologically anxious state though they are recognized as successful. Based on the research a paradigm model are derived and participants are classified into three categories. Based on these categories students need for psychological stability and the experiences of diverse programs and opportunities to engage with various majors. Colleges have to offer chances for students to interact with peers beyond their department boundaries.
A Study on the Relationship between the Consumption Value and Purchase Behavior of Functional Cosmetics: Focusing on the Millennial Generations
Authors:   The Korean Society of Culture and Convergence, Kim Daye , Chon Haejung
Published: November 2023

The purpose of this study is to analyze the relationship between the consumption value of functional cosmetics and purchase behavior, and to provide basic data to effectively establish marketing strategies such as developing new products and promoting sales of functional cosmetics. Through the production of the questionnaire, data were collected from female consumers in their 20s and 30s who had purchased functional cosmetics and analyzed using the SPSSWIN 21.0 program. The higher the hedonic value of functional cosmetics, the higher the willingness to repurchase, and the higher the hedonic value and practical value, the higher the willingness to purchase and recommend others. It was found that hedonic value and practical value were important variables in increasing the purchasing behavior of functional cosmetics. In other words, product development and marketing strategies that can pursue practical and hedonic values are needed to increase the purchase behavior and intention to repurchase functional cosmetics.
Estimasi Ukuran Butir Pasir Menggunakan Citra Sentinel-2 pada Sungai Rejali, Kabupaten Lumajang
Authors: Fathoni Mohammad Naufal , Hadmoko Danang Sri , Wibowo Sandy Budi
Published: November 2023

Lahar hujan merupakan suatu fenomena kebencanaan yang mengancam daerah sekitar gunungapi, namun juga memiliki dampak positif berupa potensi pertambangan yang besar. Berdasarkan hal tersebut perlu adanya pengelolaan dan perencanaan, didukung oleh informasi spasial yang memadai salah satunya adalah ukuran butir. Berkembangnya produk penginderaan jauh dan sistem informasi geografi dapat digunakan sebagai penyedia data spasial ukuran butir. Fokus penelitian ini adalah pemanfaatan Citra Sentinel-2 melalui indeks ukuran butir untuk mengestimasi ukuran butir menggunakan pendekatan empiris. Tahap penelitian terdiri dari pra-pemrosesan citra, pengambilan ukuran butir lapangan, analisis laboratorium, pemodelan empiris, dan identifikasi sebaran ukuran butir. Hasil penelitian menunjukkan indeks ukuran butir berkorelasi terhadap ukuran butir dan dapat digunakan sebagai variabel pemodelan. Ukuran butir pada lokasi penelitian berkisar antara -0.050 Φ sampai 11.828 Φ. Nilai validitas tergolong baik dikarenakan model memiliki nilai kesalahan estimasi yang setara dengan satu kelas ukuran butir. Distribusi ukuran butir menunjukkan semakin jauh transportasi material diiringi dengan semakin kecilnya ukuran butir.
Rancang Bangun Kotak Penyimpanan Dengan Akses Masuk Menggunakan Rfid Berbasis IOT (Internet Of Things)
Authors: Affandi Mohammad Misbakhul , Abidin Zainal
Published: November 2023

A strongbox is a place to store goods, usually used at home, tourist attractions, libraries, sports fields or other public places. The function of the cabinet as a storage area certainly has a high level of security, because valuables are stored in it. The security of a safe cabinet depends heavily on the strength of its door lock. To this day, traditional metal safety locks are still often used. In addition to looking old-fashioned, the use of such locks is also not effective for securing items in a safe or a storage area. Therefore, an innovation is needed that can increase the level of security of a safe or storage cabinet by using RFID entry access and covert to the internet (IoT). The stages of research in this thesis include, literature study, system design, hardware design and software design, System Integration and testing stages. Based on the results of tests that have been carried out both on hardware and software that has been made and see the purpose of the research, it can be concluded as follows: this equipment has been tested and can be used as a locker for storing goods that has a higher level of security compared to conventional locks and can be controlled and monitored with a semartphone.
Desain Integerated Smart Sensor Berbasis Jaringan Syaraf Tiruan untuk deteksi dini Kebakaran
Authors: Aziz As'ad Shidqy , Sesoca Jendra , Firmanto Bayu
Published: November 2023

Kebakaran berdasarkan Fire Triangle terjadi karena interaksi sumber berupa panas, oksigen dan bahan bakar . Dari interaksi ketiga unsur tersebut akan timbul nyala api Setiap tempat kerja memiliki risiko terhadap kebakaran. Risiko tersebut berbeda antar satu tempat kerja dengan tempat kerja lainnya. Semakin tinggi risiko terjadinya kebakaran, maka semakin besar kerugian yang akan di tanggung oleh tempat kerja tersebut. Tujuan utama dari penelitian ini  adalah merancang dan membangun Smart Detector untuk deteksi dini kebakaran dengan akurasi yang tinggi menggunakan tiga sensor yang terintegerasi berbasis Jaringan Syaraf Tiruan. Hasil pengujian sensor didaptkan nilai MSE 0,61 untuk sensor BH1750; 0,26 untuk sensor DHT11; dan 0,52 untuk sensor MQ-7. Berdasarkan analisa confution matrix dari pelatihan dan pengujian jaringan syaraf tiruan memperoleh  akurasi sebesar 100%, recall sebesar 100% dan precission sebesar 100%
Pengaruh Latihan Sepeda Virtual Terhadap Sensori-Motor Ekstremitas Bawah Pasien Pasca Stroke
Authors: Lesmana I Putu Dody , Yuana Dia Bitari Mei , Mukhlisoh Nanik Anita , Widiawan Beni , Hakim Lukman , Suryana Arinda Lironika
Published: November 2023

Defisit neurologis yang sering didapati pasca stroke adalah penurunan fungsi sensorik dan motorik. Terapi rehabilitasi yang tepat akan memberikan pemulihan sensori motor yang optimal. Fisioterapi menggunakan modalitas latihan motorik berupa latihan sepeda virtual merupakan salah satu pilihan program rehabilitasi. Jenis latihan ini dapat memperbaiki fungsi keseimbangan dan koordinasi ekstrimitas bawah. Tujuan penelitian ini untuk mengetahui pengaruh latihan sepeda berbasis Virtual Reality Augmented Cycling (VRAC) terhadap respon sensorimotor pasien pasca stroke kronis.Rancangan penelitian adalah quasi experimental dengan post test only control group design. Subyek penelitian sebanyak 15 orang terbagi dalam dua kelompok yaitu 8 orang pasien pasca stroke dan 7 orang kontrol sehat, diambil secara purposive sampling dan telah memenuhi kriteria inklusi. Semua subyek mengikuti program latihan sepeda virtual 2 kali dalam seminggu selama 3 bulan di Poli Rehabilitasi Medik RSD Kalisat Jember. Respon sensorimotor diukur dari kecepatan kayuhan (RPM) dengan tiga lintasan. Data dideskripsikan dalam bentuk mean±SD dan dianalisis uji independent T-Test menggunakan SPSS V.22.0.Rata-rata kecepatan kayuhan pasien pasca stroke meningkat tiap minggu selama latihan. Terdapat perbedaan kayuhan pedal pada lintasan lebar, lintasan lebar berpenghalang dan lintasan sempit yang signifikan antara pasien pasca stroke dengan kontrol (p<0,001).Simpulan: Latihan sepeda virtual dapat memperbaiki sensorimotor pasien pasca stroke kronis.
Penerapan Algoritma K-Means Dalam Menentukan Kualitas Satuan Pendidikan Berdasarkan Nilai Internal Dan Eksternal
Authors: Yanto Dwi , Susanto Heri , Zulkifli Kiky , Gupron Fiqri Romadhonal
Published: November 2023

Dinas Pendidikan Kabupaten probolinggo adalah dinas yang menaungi sekolah-sekolah yang ada di Kabupaten Probolinggo. Pendidikan dasar memiliki peran penting dalam pembangunan suatu negara, membentuk generasi muda yang berkualitas dan berkontribusi positif bagi masyarakat. Dinas Pendidikan Kabupaten Probolinggo membutuhkan data pengelompokan kualitas sekolah dasar yang ada di Kabupaten Probolinggo. Dimana hasil pengelompokan kualitas tersebut akan di gunakan Dinas Pendidikan Kabupaten Probolinggo untuk membina sekolah dasar yang memiliki kualitas kurang agar bisa lebih maju lagi. Selain itu pengelompokkan kualitas sekolah ini juga akan digunakan untuk memonitoring perkembangan sekolah dasar yang ada di Kabupaten Probolinggo. Pengelompokan kualitas sekolah tidak hanya berdasarkan indikator internal tetapi juga indikator eksternal. Oleh karena itu, penelitian ini menggunakan metode klasterisasi dengan algoritma K-Means untuk mengelompokkan sekolah dasar berdasarkan nilai internal dan eksternal. Penelitian ini bertujuan untuk membantu Dinas Pendidikan Kabupaten Probolinggo dalam menggambarkan kualitas sekolah dasar di berbagai cluster. Hasil analisis ini memberikan pemahaman mendalam tentang faktor-faktor yang memengaruhi kualitas pendidikan dasar dan memberikan rekomendasi yang baik untuk meningkatkan kualitas pendidikan. Berdasarkan hasil penelitian yang telah dilakukan  dengan metode K-Means terhadap pengelompokan kualitas sekolah dasar berdasarkan nilai internal dan eksternal sekolah, diperoleh hasil akhir berupa cluster yang keanggotaannya dengan kategori sekolah Unggul sejumlah 50%, Berkembang sejumlah 13% sekolah dan kategori Kurang Baik 36%. Penelitian ini dapat menjadi dasar bagi pembuat kebijakan pendidikan,  memonitoring perkembangan sekolah dasar yang ada di wilayah Kabupaten Probolinggo dan dapat melakukan pembinaan pada sekolah yang dipandang perlu.
Digitalisasi A’malul Yaum Berbasis Android
Authors: Rizal Fathur
Published: November 2023

A’malul Yaum merupakan kitab kecil yang berisi kumpulan amalan-amalan harian yang dimiliki oleh Pesantren Nurul Jadid yang berisi amalan harian, tuntunan sholat, sholawat, do’a sehari-hari dan qoshidah. A’malul Yaum saat ini masih belum dalam bentuk digital serta kemungkinan kecil akan jarang dibawa oleh masyarakat setiap harinya, beda halnya dengan smartphone yang saat ini sering dibawa oleh kebanyakan masyarakat dalam setiap aktivitas hariannya. Oleh sebab itu dalam penelitian akan mengembangkan digitalisasi A’malul Yaum (kumpulan amalan harian) berbasis Android. Model pengembangan sistem yang diguanakan dalam penelitian ini menggunakan model waterfall. Model Waterfall merupakan pendekatan pengembangan sistem yang sistematis serta sekuensial yang meliputi tahapan analisis kebutuhan, desain sistem, implementasi/pengkodean, uji coba, penyebaran, dan perbaikan. Hasil penelitian menghasilkan aplikasi kumpulan amalan harian yang dapat digunakan oleh masyarakat umum serta hasil pengujian blackbox testing aplikasi ini menunjukkan hasil yang sesuai serta hasil penilaian rating aplikasi ini cukup memuaskan berdasarkan hasil review bintang di google playstore.
PEMBERDAYAAN WANITA BERUPA PELATIHAN RIAS WAJAH MALAM DI ERA PANDEMI COVID
Authors: Fitria Hansyah Fatmasari  , Ria Andriani Mukti  , Iut Nuraini  , Sulistiami
Published: November 2023

Abstract:The purpose of community service were adding insight and skills about evening make up of Mojo residents, Surabaya City especially for entrepreneurship in the field of beauty services. Also introducing/promoting the PVKK Study Program to the wider community. Research design were survey, proposal preparation , licensing management, preparation of materials to be delivered, preparation of training tools and materials. The results of community service were ability of residents about night make up look for themselves and clients, residents had the courage to take MUA business opportunities, improving the family economy during the covid-19 period. The conclusion is that the Mojo residents of the Gubeng sub-district are able to do night make up look to improve the family economy.Keyword : Training, Night make up look, Mojo residentAbstrak:Tujuan pengabdian masyarakat adalah menambah wawasan dan keterampilan make up wajah malam Warga Mojo, Kota surabaya khusunya untuk kewirausahaan di bidang jasa kecantikan, memperkenalkan/mempromosikan Program Studi PVKK ke masyarakat luas. Rancangan penelitian berupa : survey, penyusuan proposal, pengurusan perijinan, persipan materi yang akan disampaikan, persiapan alat dan bahan pelatihan. Hasil dari pengabdian masyakat adalah warga mampu melakukan make up malam pada diri sendiri dan klien, warga sudah berani untuk mengambil peluang bisnis MUA. meningkatkan perekonomian keluarga dimasa covid-19. Kesimpulan warga mojo kecamatan gubeng mampu melakukan tata rias wajah malam untuk meningkatkan perekonomian keluarga.Kata kunci : Pelatihan, Make up Malam, Warga Mojo
ANALISIS PENERAPAN AKUNTANSI PIUTANG PADA KPRI BAHAGIA DEPAG KABUPATEN JOMBANG
Authors: Ahmadun Ludfi  , Putri Laili Nur Malikha  , Dwi Ari Pertiwi
Published: November 2023

Cooperative is a business activity carried out by a group of people to achieve common interests and achieve the welfare of its members. The accounting system is used in cooperatives to make managing the company easier. Koperasi Bahagia Depag Cooperative of the Ministry of Religion is a savings and loan cooperative that aims to achieve the welfare of its members. The main activity of this cooperative is savings and loans in the form of short-term and long-term, so that in its implementation it is necessary to have a receivables accounting system so that problems do not arise in its implementation. In this case, of course, proper accounts receivable accounting is needed so that the settlement of receivables can be carried out at a member meeting. The purpose of the study was to find out how the accounts receivable accounting system was applied to cooperatives, and to determine the accounting system used in the loan or receivable cycle at Happy Cooperative of the Ministry of Religion.
PENERAPAN TEKNOLOGI TEPAT GUNA DI UKM JAMU CUKA REMPAH
Authors: Widiasih Wiwin , Satoto Handy Febri , Hermawati Fajar Astuti , Faizah Nur , Syanindita Previa
Published: November 2023

Pada masa pandemi Covid-19 banyak UKM terdampak, termasuk yang dialami oleh UD. Intansari Raya yaitu penjualan menurun hingga 60%. UD. Intansari Raya merupakan sebuah UKM di Wage Kecamatan Taman kabupaten Sidoarjo yang memiliki produksi jamu cuka rempah, berdiri sejak Tahun 2012 dan beranggotakan tujuh pekerja. Produk tersebut dinilai unik karena berciri khas dan mampu mengangkat kearifan lokal Indonesia dalam hal jamu atau herbal yang memiliki banyak manfaat. UKM tersebut telah memiliki IUMK dan NIB, selain itu juga berkomitmen dalam pengelolaan dan pemantauan dampak lingkungan yang terjadi akibat aktivitas usaha dan bersedia diawasi oleh instansi yang berwenang dengan dibuktikan memiliki SPPL. Permasalahan yang dihadapi saat ini yaitu dalam proses produksi masih sangat sederhana serta alat fermentor diperlukan pengadaan untuk meningkatkan produktivitas karena jumlahnya sangat terbatas. Rak juga dibutuhkan oleh UD. Intansari Raya untuk tempat penyimpanan bahan bakuan hasil produksi. Solusi yang ditawarkan pada kegiatan ini yaitu diadakan penerapan TTG dengan melakukan pengadaan alat fermentor, tong, selang dan aerator. Dengan diterapkan TTG dan pengadaan alat fermentor, UKM dapat menaikkan jumlah produksi. Sedangkan dengan ditambahkan rak juga dapat menampung raw material dan hasil produksi.
New insight into the role of macrophages in ovarian function and ovarian aging
Authors: Tang Maoxing , Zhao Manzhi , Shi Yuhua
Published: November 2023

Macrophages (MΦs) are the most abundant leukocytes in mammalian ovaries that have heterogeneity and plasticity. A body of evidence has indicated that these cells are important in maintaining ovarian homeostasis and they play critical roles in ovarian physiological events, such as folliculogenesis, ovulation, corpus luteum formation and regression. As females age, ovarian tissue microenvironment is typified by chronic inflammation with exacerbated ovarian fibrosis. In response to specific danger signals within aged ovaries, macrophages polarize into different M1 or M2 phenotypes, and specialize in unique functions to participate in the ovarian aging process. In this review, we will focus on the physiologic roles of MΦs in normal ovarian functions. Furthermore, we will discuss the roles of MΦs in the process of ovarian senescence, as well as the novel techniques applied in this field.
The Kunming-Montreal Global Biodiversity Framework: what it does and does not do, and how to improve it
Authors: Hughes Alice C. , Grumbine R. Edward
Published: November 2023

The Kunming-Montreal Global Biodiversity Framework (GBF) marks one of the most ambitious environmental agreements of the 21st century. Yet despite the ambition, and the considerable change in approach since negotiating its predecessor (the 2025 Vision and Aichi targets), the many pressures, including working through a global pandemic mean that the final agreement, despite several years of delay, is weaker than might have been hoped for. The GBF provides a set of four goals, composed of 23 targets (and a series of supporting annexes) which explore the options for conservation, restoration and sustainable use of biodiversity, and the mobilisation of necessary resources to maintain life on Earth. In this perspective we systematically examine the composition of the GBF, exploring what the targets lack and what weaknesses exist in text. We also detail the link between the targets and the key indicators which can be used to track success toward fulfilling the targets. We offer key recommendations which could help strengthen the application of various targets, and show where the indicators could be improved to provide more detailed information to monitor progress. Furthermore, we discuss the association between targets and their indicators, and detail where indicators may lack the necessary temporal resolution or other elements. Finally, we discuss how various actors might better prepare for the successor to the GBF in 2030 and what has been learnt about the negotiating process, including lessons to help ensure that future agreements can circumnavigate issues which may have weakened the agreement.
Inhibition of T-cell activity in alopecia areata: recent developments and new directions
Authors: Passeron Thierry , King Brett , Seneschal Julien , Steinhoff Martin , Jabbari Ali , Ohyama Manabu , Tobin Desmond J. , Randhawa Simran , Winkler Aaron , Telliez Jean-Baptiste , Martin David , Lejeune Alexandre
Published: November 2023

Alopecia areata (AA) is an autoimmune disease that has a complex underlying immunopathogenesis characterized by nonscarring hair loss ranging from small bald patches to complete loss of scalp, face, and/or body hair. Although the etiopathogenesis of AA has not yet been fully characterized, immune privilege collapse at the hair follicle (HF) followed by T-cell receptor recognition of exposed HF autoantigens by autoreactive cytotoxic CD8+ T cells is now understood to play a central role. Few treatment options are available, with the Janus kinase (JAK) 1/2 inhibitor baricitinib (2022) and the selective JAK3/tyrosine kinase expressed in hepatocellular carcinoma (TEC) inhibitor ritlecitinib (2023) being the only US Food and Drug Administration–approved systemic medications thus far for severe AA. Several other treatments are used off-label with limited efficacy and/or suboptimal safety and tolerability. With an increased understanding of the T-cell–mediated autoimmune and inflammatory pathogenesis of AA, additional therapeutic pathways beyond JAK inhibition are currently under investigation for the development of AA therapies. This narrative review presents a detailed overview about the role of T cells and T-cell–signaling pathways in the pathogenesis of AA, with a focus on those pathways targeted by drugs in clinical development for the treatment of AA. A detailed summary of new drugs targeting these pathways with expert commentary on future directions for AA drug development and the importance of targeting multiple T-cell–signaling pathways is also provided in this review.
A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation
Authors: Hölken Johanna Maria , Friedrich Katja , Merkel Marion , Blasius Nelli , Engels Ursula , Buhl Timo , Mewes Karsten Rüdiger , Vierkotten Lars , Teusch Nicole Elisabeth
Published: November 2023

We have integrated dermal dendritic cell surrogates originally generated from the cell line THP-1 as central mediators of the immune reaction in a human full-thickness skin model. Accordingly, sensitizer treatment of THP-1-derived CD14-, CD11c+ immature dendritic cells (iDCs) resulted in the phosphorylation of p38 MAPK in the presence of 1-chloro-2,4-dinitrobenzene (DNCB) (2.6-fold) as well as in degradation of the inhibitor protein kappa B alpha (IκBα) upon incubation with NiSO4 (1.6-fold). Furthermore, NiSO4 led to an increase in mRNA levels of IL-6 (2.4-fold), TNF-α (2-fold) and of IL-8 (15-fold). These results were confirmed on the protein level, with even stronger effects on cytokine release in the presence of NiSO4: Cytokine secretion was significantly increased for IL-8 (147-fold), IL-6 (11.8-fold) and IL-1β (28.8-fold). Notably, DNCB treatment revealed an increase for IL-8 (28.6-fold) and IL-1β (5.6-fold). Importantly, NiSO4 treatment of isolated iDCs as well as of iDCs integrated as dermal dendritic cell surrogates into our full-thickness skin model (SM) induced the upregulation of the adhesion molecule clusters of differentiation (CD)54 (iDCs: 1.2-fold; SM: 1.3-fold) and the co-stimulatory molecule and DC maturation marker CD86 (iDCs ~1.4-fold; SM:~1.5-fold) surface marker expression. Noteworthy, the expression of CD54 and CD86 could be suppressed by dexamethasone treatment on isolated iDCs (CD54: 1.3-fold; CD86: 2.1-fold) as well as on the tissue-integrated iDCs (CD54: 1.4-fold; CD86: 1.6-fold). In conclusion, we were able to integrate THP-1-derived iDCs as functional dermal dendritic cell surrogates allowing the qualitative identification of potential sensitizers on the one hand, and drug candidates that potentially suppress sensitization on the other hand in a 3D human skin model corresponding to the 3R principles (“replace”, “reduce” and “refine”).
Long-term changes in bloom dynamics of Southern and Central Baltic cold-water phytoplankton
Authors: Paul Carolin , Gräwe Ulf , Kremp Anke
Published: November 2023

In the Baltic Sea, cold-water adapted dinoflagellates and diatoms dominate the phytoplankton spring bloom of the Northern and Eastern Basins of the Baltic Sea. In the Central and Southern parts, where such species are less prominent, they cause occasional biomass peaks. We hypothesized that these dynamics correlate with ice cover, sea surface temperature (SST), and water transport processes, as the large Basins of the Central Baltic Sea are too deep to build-up blooms from their own seed banks. Long-term monitoring data from the past 40 and 20 years in the central and southern Baltic Sea, respectively, were analyzed here for biomass development of five cold-adapted taxa: the diatoms Pauliella taeniata, Thalassiosira baltica, Thalassiosira levanderi and Melosira spp. and the dinoflagellate Peridinella catenata. Results show that diatoms generally reached high biomass peaks in the 1980s and in shorter periods from 1995-1997, 2003- 2006, and 2010-2013 in all areas. We detected good correlations with the length of the ice cover period as well as low minimum and mean winter and spring SSTs. In contrast, biomass dynamics of the dinoflagellate P. catenata are more independent from these factors but have decreased strongly since the beginning of the 21st century. A numerical ocean model analysis confirmed the hypothesis that large blooms in the deep basins are seeded through water transport from adjacent shallow, ice-covered coastal areas such as the Gulf of Finland and the Gulf of Riga. Our results show that under ongoing climate warming, the common cold-water species may disappear from spring blooms in southern and central areas with unknown consequences for the ecosystem.
Epidemiological analysis of axillary apocrine bromhidrosis in China: a survey from Chinese higher education students
Authors: Zhang Lei , Cheng Jiaqi , Wang Cangyu , Zhao Junhong , Zhang Cuiping , Li Haihong
Published: November 2023

Background

There are few epidemiological data on axillary apocrine bromhidrosis (AAB) in the Chinese population, making it impossible to accurately estimate its prevalence or impact on individuals.

Objective

To estimate the prevalence of AAB in China, and to survey and compare the psychological status of individuals with and without AAB.

Methods

Students in several universities in China were surveyed online for AAB, and the prevalence of AAB was calculated. The Symptom Checklist 90 (SCL-90) was used to evaluate the psychological status.

Results

The prevalence of AAB in the surveyed students was 7.5% (194/2571). The projected number of Chinese higher education students with AAB was about 3 million. The onset age of AAB was mainly between 11 and 20 years old (79.90%, 155/194). 68.04% (132/194) of individuals with AAB had a positive family history, and 60.30% (117/194) had wet earwax. Individuals with AAB often felt depression, anxiety, loneliness and social alienation, and scored significantly higher on the nine primary psychological symptom dimensions than individuals without AAB.

Conclusion

AAB affects a small proportion but large numbers of Chinese population. China and the West or East-Asia and the West have different perception, recognition and treatment preferences for AAB.
The relationship between region of residence, socio-demographic factors, and healthcare utilization among Saudi citizens: insights from the 2013 Saudi Health Interview Survey
Authors: Aljohani Motab , Donnelly Michael , Al Sumaih Ibrahim , O'Neill Ciaran
Published: November 2023

Background

There is a dearth of research on the nature and extent of variation in patterns of health service use in Saudi Arabia. This is an important gap in knowledge, given ongoing efforts to improve service provision and delivery. This study examined the relationship between the region of residence and socio-demographic factors and patterns of health service use in Saudi Arabia.

Methods

Data were taken from the 2013 Saudi Health Interview Survey (SHIS), a national multistage survey of individuals aged 15 years and above in Saudi Arabia. Data included measures of service use, respondent health, socio-demographic characteristics, and region or area of residence. Descriptive statistics, Chi-square tests, and multivariable logistic regression analyses were used to describe the data and examine the likelihood of a respondent visiting a doctor or healthcare professional in the preceding 12 months. In addition, the analyses examined the role of health and socio-demographic characteristics within selected regions.

Results

The increased likelihood of using health services in terms of visiting a doctor or healthcare professional was related to poor health status, being female, married, having a low income, and residing in particular regions. Respondents aged <65 and who lived furthest from service providers were less likely to visit a doctor or other health professionals (p < 0.01). Residents who lived in Riyadh, Al Medina, Baha, or Aseer demonstrated a higher likelihood of service utilization compared to respondents residing in other regions (p < 0.05). In sub-group analyses, there was variation between regions with respect to socio-demographic status and distance to service.

Conclusion

Region of residence and income level, in particular, may help to explain the likelihood of primary care use in Saudi Arabia and the distinct patterns of service use in relation to regional and socio-demographic characteristics. The relationship between regional variation in service utilization and the socio-demographic characteristics of respondents may reflect differences with respect to population need, enabling, and predisposing factors as represented in Anderson's Behavioral Model (ABM) of health service use. The findings from this study underscore the importance of considering region or area of residence when seeking to understand the utilization of health services, particularly primary care services.
Exploring the origins of decreased sound tolerance in tinnitus patients
Authors: Kim Eun Hye , Shin Seung-Ho , Byun Sung Wan , Lee Ho Yun
Published: November 2023

This study aimed to confirm the characteristics of auditory function alterations in tinnitus patients with concomitant decreased sound tolerance (ST) and provide insights for developing tailored therapeutic approaches. A retrospective analysis was conducted on patient records from a tertiary university hospital's tinnitus clinic between March 2020 and June 2023. Demographic attributes and audiological profiles were reviewed. Patients were categorized into Group 1 if loudness discomfort level test outcomes were 77 dB or below, measured using an average of frequencies from 250 Hz to 8 kHz. The remaining patients were allocated to Group 2. Among the 434 tinnitus patients, 115 (26.5%) demonstrated decreased ST and were classified as Group 1. This group exhibited higher DPOAE amplitudes (p < 0.001), shortened latency, and decreased threshold of ABR wave V bilaterally (p < 0.05). No significant disparities were observed in gender, age, tinnitus handicap inventory, visual analog scale, and pure-tone audiometry results except subjective hyperacusis. Binary logistic regression analysis utilizing the forward conditional method revealed that the difference between groups was independently linked to DPOAE response at 7,277 Hz on the left side [B = 0.093, p < 0.001, EXP(B) = 1.07, 95% CI = 1.044–1.153]. Increased DPOAE amplitude and shorter and decreased ABR wave V in tinnitus patients with decreased ST might suggest a possible association with lesions in or around the superior olivary complex or higher central auditory pathway, potentially linked to the inhibition of medial olivocochlear efferents.
Activity-regulated cytoskeletal-associated protein (Arc) in presynaptic terminals and extracellular vesicles in hippocampal synapses
Authors: Ringsevjen Håvard , Egbenya Daniel Lawer , Bieler Malte , Davanger Svend , Hussain Suleman
Published: November 2023

The activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is a neuron-specific immediate early gene (IEG) product. The protein regulates synaptic strength through modulation of spine density and morphology, AMPA receptor endocytosis, and as being part of a retrovirus-like inter-cellular communication mechanism. However, little is known about the detailed subsynaptic localization of the protein, and especially its possible presynaptic localization. In the present study, we provide novel electron microscopical data of Arc localization at hippocampal Schaffer collateral synapses in the CA1 region. The protein was found in both pre-and postsynaptic cytoplasm in a majority of synapses, associated with small vesicles. We also observed multivesicular body-like structures positive for Arc. Furthermore, the protein was located over the presynaptic active zone and the postsynaptic density. The relative concentration of Arc was 25% higher in the postsynaptic spine than in the presynaptic terminal. Notably, small extracellular vesicles labeled for Arc were detected in the synaptic cleft or close to the synapse, supporting a possible transsynaptic transmission of the protein in the brain.
Remote electrical neuromodulation (REN) wearable device for adolescents with migraine: a real-world study of high-frequency abortive treatment suggests preventive effects
Authors: Monteith Teshamae S. , Stark-Inbar Alit , Shmuely Sharon , Harris Dagan , Garas Sandy , Ironi Alon , Kalika Paige , Irwin Samantha L.
Published: November 2023

Introduction

Migraine is a chronic neurological disease manifesting as attacks of disabling head pain and associated symptoms. Remote electrical neuromodulation (REN) is a non-pharmacological, prescribed, wearable device (Nerivio®). This device has been certified by the FDA for the acute and/or preventive treatment of migraine with or without aura in patients 12 years of age or older. The device is affixed to the user’s arm during 45-min treatment sessions and is operated using a smartphone app. This study (NCT05769322) aims to evaluate whether frequent use of REN for the acute treatment of migraine in adolescents resulted in a reduction in monthly migraine treatment days (MMTD), as previously demonstrated in adults through a dedicated prevention clinical trial (NCT04828707).

Methods

The study included real-world prospective data from adolescent patients who used REN on at least 10 days every 28-day month, following the REN migraine prevention guideline of an every-other-day pattern. Additional requirements were at least three REN treatment days in each of the two subsequent months. The number of MMTD was used as a proxy measure for the number of monthly migraine days (MMD). The change in MMTD from the first month, taken as a “baseline,” to each of the following months was used to evaluate the presence and size of potential migraine preventive benefits of REN in adolescents.

Results

A total of 83 adolescents were eligible for analysis. The users were 15.9 ± 1.3 years of age (mean ± SD), and 89% of them were female. The results demonstrated a substantial month-to-month reduction in the mean (±SD) number of REN treatment days from 12.6 (±3.2) MMTD in the first month to 9.0 (±4.8) MMTD in the second month (p < 0.001), and a further decrease to 7.4 (±4.2) MMTD in the third month (p < 0.001). This indicates an accumulative reduction of 5.2 (±4.8) mean REN MMTD from the first month to the third month of consecutive REN treatment. The users also reported consistent 2-h acute pain responses in at least 50% of their treated attacks, with 61.9% of the users reported experiencing pain relief, 24.5% reported pain freedom, 67.4% indicated relief in functional disability, and 41.3% reported complete freedom from functional disability.

Conclusion

The frequent use of REN among adolescents as an acute treatment for migraine attacks resulted in a decrease in the mean number of monthly treatment days in the subsequent months, suggesting that REN may have potential preventive benefits for migraine in this subpopulation.
Wave In in auditory brainstem response suggests a high possibility of a high jugular bulb
Authors: Liu Jia , Xie Wanqin , Ding Yan , Hu Ya , Lai Ruosha , Hu Peng , Zhu Ganghua
Published: November 2023

Background

Wave In, which refers to the negativity between waves I and II in auditory brainstem response (ABR), is an electrophysiological phenomenon observed in previous studies. The term “high jugular bulb” (HJB) describes a jugular bulb that is located in a high position in the posterior aspect of the internal acoustic canal. The present study aimed to explore the correlation between wave In and the possibility of a HJB.

Methods

This retrospective study included a cohort of pediatric patients diagnosed with profound hearing loss who were enrolled in a government-sponsored cochlear implantation program at an academic medical center between January 2019 and December 2022. The analysis involved examining the results obtained from the ABR test and high-resolution computed tomography (HRCT) of the temporal bone in the patients. The position of the jugular bulb was classified according to the Manjila and Semaan classification.

Results

A total of 221 pediatric patients were included in the study. Twenty-four patients, with a median age of 3 years and a range of 1–7 years, showed significant bilateral (n = 21) or unilateral (n = 3) wave In (mean latency: right ear, 2.16 ms ± 0.22 ms; left ear, 2.20 ms ± 0.22 ms). The remaining 197 patients showed an absence of ABR. The HRCT images revealed that 18 of the 24 patients (75%) had HJB, but only 41 of the 197 patients who lacked ABR (20.8%) showed signs of HJB. The ratio difference was considered statistically significant based on the chi-squared test (χ2 = 32.10, p < 0.01). More than 50% of the HJBs were categorized as type 4 jugular bulbs, which are located above the inferior margin of the internal auditory canal.

Conclusion

ABR wave In in pediatric patients with profound hearing loss suggests a high possibility of HJB. The physiological mechanism underlying this correlation needs further investigation.