bluuebunny/crossref_metadata_2025 huggingface dataset:
Arterial hypertension and anticancer drug therapy: pathophysiological relationships and clinical significance
Authors: Satalkina T. S. , Brodskaya T. A. , Geltser B. I.
Published: January 2023

Arterial hypertension (AH) is one of the most common cardiovascular complications of anticancer drug therapy. In this review article, we consider the main groups of anticancer drugs that may cause the development of iatrogenic AH, the pathophysiological mechanisms of increased blood pressure, as well as the clinical significance of AH developed during treatment with cytostatics and targeted drugs in the practice of an oncologist and a cardiologist. It was found that AH is frequently associated with the use of angiogenesis inhibitors, as well as alkylating cytostatics, antimetabolites, taxanes, and proteasome inhibitors. In addition, erythropoietins, glucocorticosteroids, and non-steroidal anti-inflammatory drugs used as part of supportive therapy may contribute to an increase in blood pressure. Management of hypertension in cancer patients is an important part of antitumor treatment therapy whose implementation contributes to improving their quality of life. Research into various clinical and pathophysiological aspects of cardiovascular disorders in cancer patients is becoming increasingly relevant, which is indicated by the rapid development of cardio-oncology, a new interdisciplinary field of knowledge aimed at developing practical recommendations for the prevention, diagnosis, and treatment of cardiovascular toxicity caused by anticancer therapy.
Nutrient and energy intake of modern university students
Authors: Gritsina O. P. , Yatsenko A. K. , Trankovskaya L. V. , Tarasenko G. A. , Mironenko Yu. K. , Sheparev A.  A. , Kovalchuk V. K.
Published: January 2023

Aim. To study the nutrient and energy intake of modern university students.

Materials and methods. 244 students aged 18–23 enrolled in specialist degree programmes were surveyed using a 24-hour dietary recall method adapted for online Google form surveying. The food intake was analysed based on the following aspects: meal frequency, intervals between meals and energy intake.

Results. According to the obtained results, 38.93 ± 3.12% of the respondents follow a 3–4 meal-a-day diet, with 3 main meals (breakfast, lunch and dinner) adhered by 71.31 ± 2.9% of students. In comparison with male respondents, female students were found to be more likely to keep main meals (74.87 ± 3.17% versus 59.65 ± 6.50%, χ2 = 4.94, p = 0.027). Additional meals (second breakfast, afternoon tea, overnight snack) were observed in 64.75 ± 3.06% of the students, with this share being significantly larger among male students (78.95 ± 5.40% versus 60.43 ± 3.58%, χ2 = 6.56, p = 0.011). About 68.44 ± 2.98% of the respondents reported long intervals between meals, which was found to be more typical of female students (71.66 ± 3.30% versus 56.14 ± 6.57%, χ2 = 4.84, p = 0.028). The energy intake of young people was established to correspond to the recommended norm in 27.40 ± 3.69% of cases.

Conclusions. The findings emphasize the importance of developing healthy eating habits in modern students, which can contribute to improving their health and increasing their educational performance.
Molecular characterization and phylogenetic analysis of kaurene synthase protein in Stevia rebaudiana MS007
Authors: Rosilan Nur Fathiah , Samsulrizal Muhammad Amirul Husni , Rani Nor Adilah A. , Samsulrizal Nurul Hidayah , Zainuddin Zarina , Sundram Tamil Chelvan Meenakshi
Published: January 2023

Stevia rebaudiana is a plant under the Asteraceae family and has been reported as a healthier alternative to sugar. Steviol glycosides (SGs) is the group of secondary metabolites responsible for the sweet taste. Among nine SGs synthesised by S. rebaudiana, stevioside and rebaudioside A are the sweetest. The biosynthetic pathway of SGs partly involves conversion of geranylgeranyl diphosphate (GGDP) into steviol, catalysed by ent- kaurene synthase (KS), ent-copalyl diphosphate synthase (CPPS), and kaurene oxidase (KO). This study focuses on in silico molecular characterization and phylogenetic analysis of KS from Malaysia’s S. rebaudiana MS007 variety (Stevia MS007). The transcriptomic dataset of S. rebaudiana accession MS007 was used in initial experiment toward analysing the KS. Through the blastx homology search using transcriptomic dataset query Cluster-31069.42907, the Stevia rebaudiana kaurene synthase (SrKS) sequence was identified with the highest similarity percentage identity (99.62%). The protein domain prediction using InterPro yields IPR005630 (terpene synthase metal-binding domain) at positions 490 to 755 and IPR001906 (terpene synthase-N-terminal-domain) at positions 258 to 477. Multiple sequence alignment was conducted using MUSCLE and MEGA-X as phylogenetic tree analysis tool for constructing the phylogenetic analysis tree. Based on the bootstrap value from the phylogenetic analysis, Cluster-31069.42907 represents relationships between the ancestors. Since both Helianthus annuus and S. rebaudiana are Asteraceae species, the bootstrap value for both species was 100%. In conclusion, this research contributes to a better understanding of Stevia MS007 KS via in silico analysis.
Enseñanza y aprendizaje de forma creativa mediante herramientas web 2.0
Authors: Proaño-Zambrano Holger Arturo , Parraga-Alava Jorge Antonio
Published: January 2023

Esta investigación tuvo como objetivo utilizar herramientas Web 2.0 como estrategias didácticas para mejorar la enseñanza y el aprendizaje en la Unidad Educativa “Bellavista” del cantón 24 de Mayo, Manabí, Ecuador. El estudio fue cuasi-experimental y las técnicas aplicadas fueron: documental, mediante la utilización de estudios similares relevantes y; de campo, a través de una encuesta aplicada a docentes y un test a un grupo de control y un grupo experimental de estudiantes. Como resultados en el test diagnóstico, el grupo de control obtuvo 85% de errores y el experimental 87%. Posterior a las clases tradicionales, el grupo control no mejoró el rendimiento (79% de errores); por el contrario, el grupo experimental que empleó herramientas web 2.0, mejoró su rendimiento en gran proporción (96% de aciertos). Se concluye que las herramientas Web 2.0 utilizadas adecuadamente permiten la obtención de aprendizajes significativos.
Knowledge and Skill Requirements of Social Workers at Family Counseling Centers to Promote the Intellectual Security of Saudi Family
Authors: Faisal M Alfreikh Amal
Published: January 2023

The present research paper aims to identify the knowledge and skill requirements of social workers at family counseling centers and identify the methods of promoting the intellectual security of Saudi families to make suggestions for the success of social workers from the perspective of workers and academicians. The author adopted the analytical-descriptive approach and applied two questionnaires for data collection. The results showed that the most important knowledge requirements are familiarity with methods that help the family invest its capabilities and acquire experience, from the perspective of workers, and training in providing the services that the family needs based on its needs and the capabilities of the center, from the perspective of academicians. The most important skill requirements are acquiring skills related to the steps of problem-solving to promote the family's intellectual security, from the perspective of workers, and acquiring skills and applying good communication methods, from the perspective of academicians. The methods of promoting intellectual security are educating families about the importance of the culture of dialog, from the perspective of workers, and educating families about interest in and observing the behavior of children, from the perspective of academicians. The workers suggested running training courses in family counseling centers to train social workers, whereas the academicians suggested increasing the number of social workers at family counseling centers to help provide professional services. The study recommended running training courses at family counseling centers to train social workers in the fields of promoting the intellectual security of Saudi families.
Female Academics’ Leaders Ownership of Leadership Skills to Form Public Awareness and Knowledge: From the Viewpoint of Media Faculties Students in Jordanian Universities
Authors: Abdel Rahman Al Souob Hana
Published: January 2023

This study aims to identify the extent of leading female academics’ ownership of leadership skills to form public awareness and knowledge, from the viewpoint of students of media faculties in Jordanian Universities. This study is classified as an analytical descriptive research. The study population consists media faculties of the Jordanian universities that teach journalism and media in which the academic women occupy leadership positions in them (Dean, Deputy Dean, Department Head), there are (4) universities that fit these criteria. The study adopted the intended non-probability sampling, which included (400) respondents from male and female students who study in the Faculties of Media and the Departments of Journalism and Media in these universities, and their total number is (1046). The study found that academic female leaders possess a high degree of technical, human, organizational, and intellectual skills to form public awareness and knowledge from the viewpoint of students. It was also found that they also possess the necessary capabilities to use and analyze numbers and information related to public awareness and knowledge. The study recommended emphasizing the importance of increasing the chances for advancing females in academic and managerial positions and to implement measures to achieve equality between the two genders, as well as the importance of possessing leadership skills and enhancing their role to better contribute to forming public awareness and knowledge among students.
The Role of Saudi Universities in Developing Women's Attitudes toward Spreading a Culture of Social Entrepreneurship
Authors: Mohamed Gehan , Aldegheiry Huda , Galalh Ayman
Published: January 2023

The current study aims to activate the role of Saudi universities in developing women's attitudes toward spreading the culture of social entrepreneurship. It relied on the method of the social survey through the stratified random sample of female students in the final levels of Saudi governmental universities in Riyadh, and the sample reached 375 individuals, and the study reached results, the most important of which is that the level of Saudi universities ’role in developing women's attitudes towards spreading the culture of social entrepreneurship is high, Whereas, the level of Saudi universities' role in developing women's attitudes related to the emotional and cognitive component toward spreading the culture of social entrepreneurship is high, while the role of Saudi universities in developing women's attitudes related to the behavioral toward spreading a culture of social entrepreneurship is average. The results also indicate that there is no variance in the study sample's estimates of the role of Saudi universities in developing women's attitudes toward social entrepreneurship.
The Consequences of Lockdown due to COVID-19 on Female Academics in Jordanian Universities
Authors: Khasawneh Amneh , Akroush Lubna , Al-Malahmeh Dima , Alibrahim Asma
Published: January 2023

This study aims to identify the consequences of lockdowns due to the coronavirus on female academics in Jordan. An online survey was distributed via social media and filled in by 131 female participants from different academic ranks in public and private universities. The study investigated four main variables: the consequences of lockdown on the social aspect, psychological aspect, and economic aspect, and also on how time was spent during the lockdown, and the correlation between these variables and other social and personal factors (such as the marital status, etc.). It was found that female academics are significantly affected on both levels: the economic aspect and the activities spent during the lockdown, followed by the psychological and social aspects. The results show that marital status played a significant role, as single female academics are generally affected more than married ones. Economically, it is found that the sector in which the participant works in has a significant impact. Female academics working in the private sector are affected more than those working in the public sector. In addition, the academic degree the participant holds plays a key role. Academics with master’s degrees are affected economically and psychologically, and even in terms of spending time during the lockdown.
Studying the Artistic Composition in the Novel ”Mohal” by the Writer Youssef Zeidan
Authors: Madallah AL-Asasfeh ALMothanna
Published: January 2023

This research deals with the study of artistic formation through a textual reading of the novel "Mohal" by standing at the significance of the title, temporal structure, the novelist's character, the voice of the narrator, and other narration techniques with artistic significance that represent dramatic events of an artistic nature, which distinguishes this work with reference to the significance of the place. In its novel dimensions and contents, and its role in highlighting the novelistic theme in a remarkable way.
Students’ Perceptions of the Virtual Learning Challenges of Islamic Science Courses During the Corona Pandemic and Ways to Reduce them
Authors: Fawaris Haifa , Al-Shboul Asma'a
Published: January 2023

As a consequence of the worldwide pandemic caused by COVID-19, universities have begun to teach in a digital format, exacerbating the integration and use of technology in methodological adaptation. The research aims to reveal the perceptions of students about the level of challenges of virtual learning and identifies ways to reduce them during the COVID-19 pandemic at the faculty of Islamic study at Yarmouk University in Jordan. The information collection method was an online questionnaire, using simple random sampling. The results demonstrate a generalized dissatisfaction among the students, being fundamental to carrying out the transition of the educational processes. Furthermore, There was no statistically significant difference at the level of significance (α = 0.05) between the two arithmetic means of the challenges of virtual learning for the forensic science courses during the COVID-19 pandemic in the College of Sharia at Yarmouk University with gender, educational level and (Bachelor, Master level), and academic achievements. However, there are many challenges they list, from these: students' interaction with virtual learning, virtual learning exams, and technical challenges.
A room-temperature, low-impedance and high-IF-bandwidth terahertz heterodyne detector based on bowtie-antenna-coupled AlGaN/GaN HEMT
Authors: Ding Qingfeng , Zhu Yifan , Xiang Lanyong , Zhang Jinfeng , Li Xinxing , Jin Lin , Shangguan Yang , Sun Jiandong , Qin Hua
Published: January 2023

In this paper, a 330 GHz terahertz heterodyne detector based on bowtie-antenna-coupled AlGaN/GaN high-electron-mobility transistor (HEMT) is designed and demonstrated. The bowtie antenna and a silicon lens couple the terahertz wave into a transmission line, in which the HEMT's channel generates both self-mixing and heterodyne signals. Compared to field-effect detectors without front low-noise amplifiers and output impedance matching, this detector boosts the intermediate-frequency (IF) bandwidth to 2.9 GHz due to a low output impedance of 505 Ω while maintaining a comparable sensitivity. With further sensitivity enhancement, such detectors would be developed into room-temperature, high-sensitivity, and high-IF-bandwidth heterodyne arrays.
Reviewing a New Optimized an ANFIS-Based Framework for Detecting Intrusion Detection System with Machine Learning Algorithms (Deep Learning Algorithm)
Authors:   Department of Computer Science and Engineering, LNCT University, Bhopal (M.P), India., Rai Khushbu , Kamble Dr. Megha ,   Department of Computer Science and Engineering, LNCT University, Bhopal (M.P), India
Published: January 2023

Today's world is becoming more interconnected due to the current global internet, communication, or ways of doing business that have recently shifted to cloud computing platforms in order to increase their speed and productivity. But such can also be affected by cyber attacks on cloud infrastructure services to be executed on various cloud platforms, increasing the number of attacks on such systems to neutralize any harm caused by a cyber attack on such cloud-based infrastructure. Although network administrators utilize intrusion detection systems (IDS) to detect threats and anomalies, they frequently only make available post-attack ready to act in cyber warfare. If we could predict risky behavior, network administrators or security-enhancing software could intervene before harm was done. Incoming intrusion detection messages should be viewed as a sequence. The fundamental function of an intrusion detection system (IDS) is to distinguish between regular and abnormal network traffic. As a result, robust intrusion detection systems (IDS) using deep learning model are required to find such cyber risk in form of threats and anomalies on cloud based infrastructure.
Computational Processes for General Intelligence The SEOM Model
Authors: Balakrishnan Prabhakar
Published: January 2023

The ‘brain-mind-intelligence’ structure may be considered analogous to a ‘computer-operating system (OS)-application’ construct. Software development would be far more difficult without the benefit of abstractions like file and memory handles, and graphical user interfaces, implemented in operating systems. The easy access to application-level semantics, provided by the infrastructure of the OS, simplifies application development.  Abstractions can play a similar role in producing intelligent systems. The power of abstractions may be determined by their ability to unify the treatment of several types of higher concepts. Unifying various concepts in the domain of intelligence, such as problems, solutions, objects, and emotions, through abstractions will be of immense value. This paper shows how ‘higher-level perceptions’ could be used to serve this objective and construct an OS-like infrastructure. With the infrastructure in place, ordinary software objects developed and deployed using standard methods, become accessible using the semantics provided by the infrastructure. Now, after brief training exercises, the objects would be available for intelligent use. The focus, therefore, is on the design of the infrastructure that could play a mind-like role in humans.

The design uses a new, non-symbolic, non-connectionist, transmutable method of representation that tackles the so-called ‘frame’ and ‘grounding’ problems of artificial intelligence. The infrastructure enables the conversion of sensory inputs to transmutable representations amenable to semantic modifications, to flexibly determine actions to perform on software objects developed externally. Furthermore, the infrastructure serves to ground and functionally manage the transmutable, connectionist, and symbolic systems. Thus, the new model plays a critical role in building intelligent systems that overcome major problems in learning and action selection, including brittleness associated with the limited semantics of purely symbolic and connectionist designs. 

The new model is then evaluated in terms of features, against criteria set forth independently by Newell, Sun, Vernon, and others. In addition, a new measure of intelligence introduced in this paper is used to quantitatively compare the proposed model with some others developed over the years. 
A Study of Determinants of SVOD OTT and the Effects of Original Contents
Authors:   Korea Association Of Cultural Economics, Seo Seongmin , Kim Kyunghyun
Published: January 2023

The importance of original contents of OTT(Over-The-Top) services has increased as a way to strengthen their competitiveness. This paper estimates the consumer demand function for the SVOD(subscription VOD) OTT services considering that SVOD service is a differentiated goods and that consumer multi-homing behaviour exists. We find that consumers have different preferences for product attributes when selecting SVOD OTT services, and that there is heterogeneity of preferences depending on consumers’ demographic characteristics. This study also estimates the consumers’ WTP(willingness to pay) for the original contents of OTT services based on the estimated demand function and the change in the number of subscribers due to the increase in the number of original contents by domestic OTT firms. We find that consumers have a higher WTP for original contents than non-original contents and the increase rate of OTT selection in accordance with the increase in the number of original contents is also higher than that of non-original contents. The results provide that there is room for the SVOD OTT market to expand, if domestic SVOD OTT services increase the number of original contents, but the decline in the selection rate of Netflix, the leading service in the industry, is small.
The View and Political Meaning of Happiness in the Happiness Index
Authors:   Korea Association Of Cultural Economics, Park Sang-jun , Won Do-yeon
Published: January 2023

In this study aims to understand the changes in happinessism that the country aims for through the analysis of happiness indicators developed into national categories in Korea. In addition, the main implications derived through changes in happiness indicators in the national category developed during the presidency of Lee Myung-Bak, Moon Jae-In, and Park Geun-Hye can be summarized in two ways.
First. The perspective of happiness that the state-oriented state-oriented happiness theory that the state-oriented relationship with social happiness theory, which has changed the relationship with social happiness theory.And this means that the direction of happiness that the direction of happiness that was considered as individual electricity of society.In particular, the standard of region structure may be seen as “social wealth” in the “social wealth” and horizontal network, reliability, reliability, reliability, and horizontal network.
Second. The policy meaning of the happiness index carries out its institutional function as a state's role in community recovery. Recent indicators have extended the perception of the multi-dimensional concept of happiness by using happiness in the direct concept of the indicator, suggesting that interest in happiness has increased more than in previous times.
And the indicator is that in the midst of misfortunes arising from social structural problems, the state is an alternative to protection for the maintenance and recovery of the community, which can be understood as the state's institutional management of community recovery.
La “ricezione” di Dante nella letteratura bielorussa
Authors: Danilchyk Aksana
Published: January 2023

For Belarusian literature, the perception of Dante’s work assumes a concrete form only at the beginning of the 20th century and is linked, above all, to the names of Janka Kupala and Maksim Bahdanovič. The literary group “Uzvyšša”, established in Belarus in 1926, and the work of Jasep Pušča ushered in the second wave of interest in Dante. After the war we find Dante’s reception in the work of Uladzimir Karatkevič, Maksim Tank and others. Finally, in 1997 comes the first translation into Belarusian of the Divine Comedy by Uladzimir Skarynkin, who also translated Vita Nova in 2011. The translation from Latin of Dante’s treatise De vulgari eloquentia was completed by the author of this article and published in 2004.
Dante presente, Dante assente. Il dibattito sulla cancellazione dai programma scolastici bulgari
Authors: Karapetkova Daria
Published: January 2023

One of the initiatives on the occasion of the 700th anniversary of Dante’s death, carried out in Bulgaria in October 2021, consisted in the publication of a monographic issue of the weekly Literaturen vestnik in a bilingual version with the title “Ancora attuale, sempre divino: Literaturen vestnik celebra Dante.” Among the thematic features contained in this issue, an important place is occupied by three surveys conducted among Bulgarian secondary school teachers, university lecturers and poets. The surveys aim to outline how Dante’s work is currently perceived and to comment on the fact that – unbeknownst to most people – the Divina Commedia has been excluded from the literature curricula since the 2018-19 academic year.
Analysis of the microelement composition of saliva in patients with comorbidities
Authors: Imanov A. M. , Mazur Yu. A. , Gadzhiev F. Ya. , Skalny A. A. , Khabadze Z. S. , Kakabadze E. M.
Published: January 2023

The microelement composition of saliva makes it possible to analyze the processes occurring in the oral cavity and the body as a whole, both under conditions of normal functioning and in the presence of pathological processes. At the same time, the technical simplicity of performing trace element analysis of salivary fluid as a possible diagnostic criterion for various diseases contributes to a significant number of studies devoted to the search for possible correlations between the trace element composition of salivary fluid and various types of pathologies. The possibility of using the analysis of the microelement composition of saliva in determining concomitant pathologies of organs and systems of the body as a whole is a promising direction in scientific research, including applied research. The article analyzes the possibilities of using microelement analysis of saliva in such pathologies as psoriasis, Parkinson's disease, schizophrenia, pathology of the gastrointestinal tract, diabetes mellitus, pathology of the cardiovascular system, giardiasis, oncological diseases. It is noted that at present, the determination of the microelement composition of saliva in various pathological conditions is considered as a promising clinical direction that allows for the simultaneous diagnosis of several diseases in real time.
Comorbidity as a factor initiating a shift in the microelement composition of saliva
Authors: Imanov A. M. , Mazur Yu. A. , Gadzhiev F. Ya. , Skalny A. A. , Khabadze Z. S. , Kakabadze E. M.
Published: January 2023

The comorbidity of diseases reflects the mutual influence of pathological conditions of individual organs and systems of the body, which requires taking into account the current state of the patient. The presence of comorbidity in modern dentistry is one of the important problems that require attention in diagnosing a patient's condition, selecting treatment tactics and predicting the results of interventions. The possibility of diagnosing concomitant diseases by changing the microelement composition of saliva makes it possible to more effectively determine their presence, the severity of the existing concomitant pathology and determine the optimal treatment tactics.

Trace elements contained in saliva regulate a number of biological processes, and their level reflects the state of homeostasis of the oral cavity, and in systemic diseases, the composition of saliva has a strong correlation with blood plasma and, therefore, can reflect the state of health of the body.

There are both comorbidity of exclusively dental pathology, and comorbidity of dental diseases with other somatic pathologies. At the same time, the determination of changes in the microelement composition of saliva may indicate the development of inflammatory processes both in the oral cavity and in the body as a whole, a decrease in antioxidant protection, damage to enzyme systems and ion channels, pathological changes in mucous membranes, etc. . The possibility of analyzing the microelement composition of saliva in assessing the comorbidity of a patient's comorbidities seems to be a promising area of research in modern dentistry.
The Influence Of Profitability On Stock Return With Inflation As A Moderating Variable
Authors: Sugito Paulus , Noormansyah Irvan , Nasution Nursanita
Published: January 2023

Abstract—This study aims to analyze the effect of profitability on stock returns with inflation as a moderating variable. The variables tested in this research are profitability proxy for Return On Assets (ROA), Return On Equity (ROE) and Net Profit Margin (NPM), inflation and stock returns. The sample of this research uses 12 automotive companies and automotive components that consistently published financial statements in the Indonesia Stock Exchange period 2013-2017. Samples were taken by purposive sampling method which is a method of samples based on certain criteria. These variables analyzed using panel data regression. In this study, testing hypotheses used the t test, F test and regression used Moderated Regression Analysis (MRA). Panel data regression results showed Adjusted R-squared of 0.153836, which means that the magnitude of the influence of the independent variable moderated by inflation on the dependent variable that can be explained by this equation model is 15.38%. While the remaining 84.62% is influenced by other factors not taken into account in this regression model. The conclusions of this research show that ROA has a significant positive effect on stock returns, ROE has a negative effect on stock returns, NPM has no effect on stock returns, ROA moderated by inflation has a negative effect on stock returns, ROE moderated by inflation has a significant positive effect on stock returns, and NPM moderated by inflation does not affect stock returns
Education Conception between the National Curriculum and Modern Islamic Boarding Schools in Adjusting the 21st Century Development in SMA Al-Izzah Batu
Authors: Soleman Mochammad , Moeins Anoesyirwan , Suriawinata Iman Sofian
Published: January 2023

The purpose of this study was to determine: (1) the socio-cultural situation in modern pesantren education. (2) the main substance of the content standard in the learning management instrument of modern Islamic boarding schools, and (3) the application of the standard concept of the education management process and its relation to the standard system of national education management and modern Islamic boarding schools at Al-Izzah Batu High School. This research method is qualitative with a case study approach. Primary data in the form of in-depth interviews with the head of the pesantren, the principal, the deputy for the curriculum, teaching staff, the head of the pesantren, students or santri Secondary data is in the form of observation and documentation study of all supporting documents related to the sub-focus, including institutional documents, which contain objectives, vision and mission, curriculum documents, and other relevant documents. Based on the results of data analysis, it can be concluded as follows: (1) culturally the existence of Al-Izzah High School can color the surrounding area by making Islamic areas by providing guidance to the community, (2) the curriculum is integrated into learning tools in the form of a syllabus and lesson plans, and (3) the National Curriculum and the Modern Islamic Boarding School Curriculum are applied in two ways, namely integrated in Teaching and Learning Activities and habituation activities by paying attention to school indicators and predetermined class indicators..
Economic Burden of HIV in a Commercially Insured Population in the United States
Authors: Chen Cindy , Donga Prina , Campbell Alicia , Taiwo Babafemi
Published: January 2023

Background: With advances in antiretroviral therapy (ART), people with HIV infection are living longer. Pre-exposure prophylaxis (PrEP) to reduce HIV infection risk continues to be underutilized in high-risk individuals. Recent data on economic burden for patients with newly diagnosed HIV-1 or initiated with PrEP are limited. Objectives: To assess characteristics, healthcare resource utilization (HRU), and costs among adults and adolescents either with newly diagnosed HIV-1 or initiated with PrEP. Methods: This retrospective observational study utilized data from the IBM MarketScan® Commercial Claims and Encounters database. Adults with newly diagnosed HIV-1 or those initiated with PrEP were included (index date was the first HIV diagnosis or PrEP prescription, respectively, between January 1, 2016, and April 30, 2021). Corresponding cohorts of adolescents were considered exploratory. Descriptive analyses were conducted to assess baseline demographics and clinical characteristics, and all-cause and HIV-related HRU and costs per patient per month (PPPM) during follow-up. Results: Data from 18 154 adults and 220 adolescents with newly diagnosed HIV and 34 123 adults and 175 adolescents initiated with PrEP were included. Approximately 70% of adolescents and 9% of adults receiving PrEP were female. Baseline depression/anxiety was present in 16.1% and 24.6% of adults and 14.5% and 45.1% of adolescents in the HIV and PrEP cohorts, respectively. Substance abuse in the HIV and PrEP cohorts, respectively, was reported in 10.1% and 7.0% of adults, and 2.7% and 17.7% of adolescents. During follow-up, among adults with newly diagnosed HIV, mean (SD) total all-cause and HIV-related PPPM costs were $2657 ($5954) and $1497 ($4463), respectively; pharmacy costs represented 47% of all-cause costs and 67% of HIV-related costs, but only 37% of patients had an HIV-related prescription. All-cause costs PPPM for adults with PrEP were $1761 ($1938), with pharmacy costs accounting for 71%. Conclusions: Despite advances in ART, patients with newly diagnosed HIV and at-risk patients receiving PrEP continue to incur HRU costs. The chronic nature of HIV warrants further exploration of factors contributing to disease burden and opportunities to improve prevention strategies.
Comparative Analysis of Machine Learning Algorithms for Early Prediction of Parkinson’s Disorder based on Voice Features
Authors: C. D. Anisha  , N. Arulanand
Published: January 2023

Parkinson Disorder (PD) is a neurological disorder which is progressive in nature and has no cure. Early diagnosis of PD plays a key role in delaying the progression of the disorder. Dysphonia is the most prominent early symptom which is exhibited by approximately 90% of PD patients. Voice features based early diagnosis with the integration of Artificial Intelligence plays a prominent role in providing accurate, non-invasive, and robust predictions to PD patients. This paper focuses on providing comparative and experimental analysis of Machine Learning (ML) algorithms for the prediction of PD based on the voice features dataset retrieved from the UCI repository. This paper presents the results from the four sampling experiments conducted with different traditional ML algorithms for the retrieved voice dataset. The results of this study make it evident that Naïve Bayes provides a highest accuracy of 89% when compared to other ML algorithms. This study helps in identifying the best ML algorithm among the traditional ML algorithms for PD prediction based on voice features dataset.
Habilitacja ks. Profesora Wincentego Myszora na podstawie dokumentacji Archiwum Archidiecezjalnego w Katowicach
Authors: Gołda Agnieszka
Published: January 2023

Omówiono procedurę habilitacyjną wybitnego polskiego patrologa, ks. Wincentego Myszora (1941-2017). Badacz biblioteki z Nag Hammadi związany był przez lata pracą badawczą i dydaktyczną z Akademią Teologii Katolickiej w Warszawie (obecnie Uniwersytet Kardynała Stefana Wyszyńskiego) i Uniwersytetem Śląskim w Katowicach. Spuścizna przekazana przez ks. W. Myszora do Archiwum Archidiecezjalnego w Katowicach umożliwiła zaprezentowanie nieznanych dotychczas faktów dotyczących kariery naukowej darczyńcy, w tym tych na temat habilitacji otrzymanej w 1982 r. Opisano działania przygotowawcze, przybliżono treść dwóch odnalezionych recenzji dorobku habilitanta, tok kolokwium i procedury wieńczące starania o uzyskanie stopnia naukowego.
Rodzima kultura i język serbołużycki w działalności pedagogicznej Annemarie Paulik - świadomej Serbołużyczanki ze wsi Rohne
Authors: Michniuk Justyna , Kowalski Mirosław
Published: January 2023

Biografie wielkich ludzi kojarzą się nam najczęściej z życiem i działalnością wybitnych władców, politycznych i duchowych liderów, dowódców zapisanych zwycięstwami armii, naukowców wyjaśniających procesy i zjawiska niewidoczne dla rzeszy społeczeństwa, artystów, aktorów i piosenkarzy odrywających nas od codzienności i choć przez chwilę przenoszących w inny świat. Jednak wielkość człowieka może być przypisana wielu innym interesującym ludziom, którzy swoje życie nakreślili pasją i zaangażowaniem w realizację ważnej społecznie idei. Bez wątpienia taką osobą jest Annemarie Müßiggang, z domu Paulik - Serbołużyczanka ze wsi Rohne (górnołużyckie Rowno) w Niemczech, w kraju związkowym Saksonia. Jej życie toczące się na terenach Górnych, później Dolnych Łużyc było silnie związane z kulturą Serbołużyczan. Annemarie Müßiggang stała się świadkiem przemian – marginalizowania kultury serbołużyckiej w wyniku nie tylko politycznych zwrotów, ale celowej polityki państwa niemieckiego. Wychowała się w rodzinie pielęgnującej serbołużyckie zwyczaje, tradycję i oczywiście język, co ukształtowało jej osobowość. Silne poczucie przynależności do narodu serbołużyckiego było jednym z powodów, dla których Annemarie Paulik wybrano jako przyszłą nauczycielkę. Była jednym z pierwszych nauczycieli, którzy rozpoczęli po wojnie pracę w nowo utworzonej w Cottbus/Chóśebuz szkole serbołużyckiej pod nazwą Serbska wuša šula (niem. Sorbische na Oberschule). W diasporze Serbołużyczan, trudno nazwać ją osobą przeciętną. Annemarie Müßiggang angażowała się również w działalność przeciwko dyskryminacji Serbołużyczan. Od początku była zaangażowana w umacnianie i rozwój rodzimej kultury mimo przeciwności i zmieniającym się ustrojom politycznym Niemiec. Ona sama i jej rodzina są najlepszym przykładem, że silna tożsamość narodowa oraz język serbołużycki mogą przetrwać, nawet w trudnych czasach. W tym przypadku miejsce urodzenia i wychowania odegrało w życiu tej Serbołużyczanki decydującą rolę i zdeterminowało jej dalsze losy jako świadomej i wykształconej serbołużyckiej nauczycielki, tłumaczki i wychowawczyni oraz matki.
Myśl pedagogiczna Profesora Mieczysława Łobockiego (1929 – 2012) – lubelskiego pedagoga, teoretyka wychowania i humanisty
Authors: Wosik-Kawala Danuta , Zubrzycka-Maciąg Teresa
Published: January 2023

Profesor Mieczysław Łobocki (1926-2012) to wybitny polski pedagog, teoretyk wychowania i humanista. Zawodowo związany z dwiema lubelskimi uczelniami: Katolickim Uniwersytetem Lubelskim  Jana Pawła II oraz Uniwersytetem Marii Curie-Skłodowskiej. Autor wielu znanych publikacji poświęconych teorii wychowania, aksjologii i metodologii badań pedagogicznych. Zwolennik i propagator idei wychowania skoncentrowanego na dziecku, jego godności i wolności. To niestrudzony badacz poszukujący uwarunkowań efektywnego wychowania, ukierunkowanego na emocjonalny i społeczny rozwój wychowanków w duchu wartości moralnych. Celem artykułu jest ukazanie syntezy  myśli pedagogicznej Profesora Mieczysława Łobockiego  na podstawie analizy Jego tekstów,   jak również osobistych, wieloletnich doświadczeń Autorek wyniesionych ze współpracy z Profesorem. Opracowanie przybliża podejście Mieczysława Łobockiego do wychowania, nacechowane wrażliwością i troską o dobro drugiego człowieka. Tekst wzbogacony jest o krótką notę biograficzną o Profesorze, rzucającą nieco światła na jego rys osobowościowy, poglądy pedagogiczne i działalność naukową.
Dwie ścieżki akademickiej kariery – wspólny horyzont uniwersyteckich wartości. Praktyki epistolograficzne Czesława Miłosza i Jana Błońskiego
Authors: Sieroń Dorota
Published: January 2023

Przeprowadzona w ramach niniejszego artykułu analiza trzydziestodziewięcioletniej korespondencji (lata 1958-1997) Czesława Miłosza i Jana Błońskiego stała się podstawą do  wskazania relacyjnego wymiaru akademickiej profesji, w której twórczo splatają się działalność badawcza i dydaktyczna. Dokonana rekonstrukcja ich akademickiej kariery to zarówno wydobycie pedagogicznego rysu w biografii światowej sławy poety – Noblisty, a zarazem konfrontacja dwóch modeli uniwersyteckich karier  (amerykańskiej i  polskiej). Warto jednak podkreślić, że pomimo zróżnicowanych dróg awansu naukowego zarówno Miłosz, jak i Błoński stali się mistrzami i jak wskazuje ich korespondencja  realizowali w pracy zawodowej te same wartości uniwersyteckie: dbałość o relację mistrz - uczeń,  uważność na prace innych uczonych i dialog z nimi oraz twórcze podejście do pracy badawczej i dydaktycznej. W niniejszym opracowaniu autorka dokonuje odkrycia nowego badawczego wymiaru listu, który nie tylko jest cennym źródłem do badań, ale dla Jana Błońskiego – badacza twórczości Czesława Miłosza stał się narzędziem badawczym, dając sposobność do konfesyjnej, a zarazem owocnej naukowo  rozmowy badacza z artystą.
Uniwersytet Franciszka Józefa w Czerniowcach miejscem rozwoju kariery naukowej i organizacyjnej Alfreda Halbana – jedynego Polaka wśród dziekanów uczelni
Authors: Radziszewska Maria
Published: January 2023

Alfred Halban należy do uczonych polskiej i światowej nauki. Podejmując w 1895 r. zatrudnienie na wydziale prawa w najmłodszym uniwersytecie austriackim – Uniwersytecie Franciszka Józefa w Czerniowcach w charakterze profesora nadzwyczajnego katedry prawa niemieckiego, miał za sobą lata pracy zawodowej w krakowskim środowisku akademickim i administracji państwowej marchii austriackiej.Celem artykułu jest próba zaprezentowania przebiegu kariery naukowej, dydaktycznej i organizacyjnej Halban w przestrzeni peryferyjnego miasta Europy Wschodniej. Zamierzenia badawcze szły w kierunku poszukiwania odpowiedzi na pytanie czy i jakie było znaczenie zmiany miejsca w rozwoju kariery naukowej Halbana? Do przedstawienia problematyki badawczej zastosowano jakościową analizę materiału źródłowego oraz studia nad literaturą przedmiotu badań.
Wołyń jako miejsce szczególne w biografiach nauczycieli dwudziestolecia międzywojennego
Authors: Gołdyn Piotr
Published: January 2023

W 1921 r. Wołyń znalazł się w granicach II Rzeczypospolitej. Przełożyło się to na organizowanie szkolnictwa pod polskimi auspicjami, choć trzeba pamiętać, że ta część Polski była różnorodna pod względem etnicznym. Przeważali oczywiście Ukraińcy, poza nimi byli Polacy, Żydzi, Niemcy i Czesi. W szkolnictwie pracowali zatem nauczyciele wywodzący się z tych narodowości, choć tu z kolei największą grupę stanowili Polacy. Wołyń można potraktować jako miejsce szczególne w biografiach nauczycieli. Dla jednych z nich było to miejsce, z którym związani byli od urodzenia, a przeważali w tej grupie Ukraińcy. Drugą grupę stanowili nauczyciele, którzy w „desperacji” poszukiwali pracy, a Wołyń stał się miejscem tych poszukiwań. Byli też tacy, dla których Wołyń stał się początkiem życia rodzinnego.
Pamięć w miejscach zapisana, czyli o specyfice semioforów Uniwersytetu Wileńskiego z perspektywy biograficznej. Studium (auto)edukacyjne
Authors: Majchrzak-Ptak Kinga
Published: January 2023

Materialne, tworzone intencjonalnie miejsca pamięci związane z przeszłością określonej zbiorowości stanowią nie tylko jeden z elementów jej pamięci kulturowej, ale równocześnie współuczestniczą w procesie permanentnego (re)konstruowania tej pamięci poprzez stwarzanie warunków do uczenia się jej. Podążając za myślą Maurice’a Halbwachsa, można przyjąć, że indywidualne „akty pamięci” stanowiące budulec (auto)definicyjny są uzależnione od społecznie zinstytucjonalizowanych zasobów pamięci, wyselekcjonowanych przez grupy, do których należą określone jednostki. Dlatego uznać można, że prowadzenie poszukiwań dotyczących uczelnianych semioforów pozwala dokonać mappingu akademickiej pamięci zbiorowej, określić specyfikę zarówno jej, jak i instytucji, której tożsamości pamięć ta jest fundamentem i tworzywem, wyznaczając ramy myślenia i działania obcujących z nią podmiotów. Wobec tego przedmiotem opracowania są semiofory związane z przeszłością Uniwersytetu Wileńskiego, tj. skoncentrowano się na przedmiotach uznawanych w danej społeczności za nośniki znaczeń i wartości, łączących wymiar semiotyczny z wymiarem materialnym, a zatem obiektach, które z założenia pełnić mają rolę miejsc pamięci. Artykuł prezentuje wyniki osadzonych w schemacie etnograficznym badań, bazujących na analizie i interpretacji danych zgromadzonych dzięki m.in. (auto)obserwacji i przeszukiwaniu źródeł wtórnych, zogniskowanej wokół pytań: Jaka jest specyfika semioforów zlokalizowanych w przestrzeni Uniwersytetu Wileńskiego? Jakie znaczenia mają semiofory w architektonicznej, społecznej, kulturowej i dydaktycznej przestrzeni Uniwersytetu Wileńskiego? Przeprowadzone poszukiwania pozwalają wnioskować, że Uniwersytet Wileński odznacza się odpowiedzialnym podejściem do upamiętniania swojej przeszłości oraz konstruowania ram pamięci zbiorowej, w których zachodzą określone procesy biograficzne, ale także, że zbiór semioforów wileńskiego uczelni cechuje pewna homogeniczność zakresu upamiętnionych podmiotów, co ma swoje implikacje edukacyjne.
Gut-brain axis in depression: Crosstalk between neuroinflammation and gut microbiota
Authors: Cai Yang , Zhang Shenyang , Zhao Sibo , Yao Honghong
Published: January 2023

Depression is the most common mental disorder and the leading cause of disability and suicide worldwide. Recently, during the COVID-19 pandemic, there has been a dramatic increase in the number of patients with depression on a global scale. Therefore, new insights into the underlying pathophysiology of depression are urgently required to develop more effective therapeutic strategies. An interesting fact is the coexistence of increased intestinal permeability and disrupted blood-brain barrier observed in patients with depression and animal models. A growing number of studies have revealed that a bidirectional interaction exists between the brain and the gastrointestinal tract, commonly termed the gut-brain axis. Emerging evidence has suggested that the regulation of neuroinflammation and gut homeostasis through the gut-brain axis is influenced by stress and depression, in which gut microbiota and microbe-derived short-chain fatty acids play a crucial role. Here, we describe the molecular and cellular mechanisms involved in the crosstalk between neuroinflammation and gut microbiota in depression. We further highlight fecal microbiota transplantation and dietary supplementation in depression and discuss their potential as therapeutic targets for depression.
Aerodynamic analysis of human walking, running and sprinting by numerical simulations
Authors: Forte Pedro , Sousa Nuno , Teixeira José Eduardo , Marinho Daniel A. , Monteiro António M. , Bragada José A. , Morais Jorge E. , Barbosa Tiago M.
Published: January 2023

Purpose

The drag in walking, running, and sprinting locomotion can be assessed by analytical procedures and experimental techniques. However, assessing the drag variations by these three main locomotion’s (i.e., walking, running, and sprinting) were not found using computational fluid dynamics. (CFD). Thus, the aim of this study was two-fold: (1) to assess the aerodynamics of human walking, running, and sprinting by CFD technique; 2) compare such aerodynamic characteristics between walking and running.

Methods

Three 3D models were produced depicting the walking, running, and sprinting locomotion techniques, converted to computer aided design models and meshed. The drag varied with locomotion type.

Results

Walking had the lowest drag, followed-up by running and then sprinting. At the same velocities, the drag was larger in walking than in running and increased with velocity.

Conclusions

In conclusion, drag varied with locomotion type. Walking had the lowest drag, followed-up by running and then sprinting. At the same velocities, the drag was larger in walking than in running and increased with velocity.