bluuebunny/crossref_metadata_2025 huggingface dataset:
INFLUENCE OF PULSE DURATION ON SURFACE ROUGHNESS IN ASSISTING ELECTRODE ELECTRIC DISCHARGE MACHINING
Authors:   University of Novi Sad, Faculty of Technical Sciences, Department of Production Engineering, Novi Sad, Serbia, Rodić Dragan , Gostimirović Marin ,   University of Novi Sad, Faculty of Technical Sciences, Department of Production Engineering, Novi Sad, Serbia, Sekulić Milenko ,   University of Novi Sad, Faculty of Technical Sciences, Department of Production Engineering, Novi Sad, Serbia, Madić Miloš ,   University of Nis, Faculty of Mechanical Engineering, Laboratory for Machine Tools and Machining, Nis, Serbia, Kulundžić Nenad ,   University of Novi Sad, Faculty of Technical Sciences, Department of Production Engineering, Novi Sad, Serbia
Published: December 2022

Electrical discharge machining (EDM) is an unconventional machining process that can machine all electrically conductive materials, regardless of their physical and metallurgical properties. Due to the efficiency of machining modern engineering materials, existing EDM methods are constantly being researched and improved or developed. This paper deals with an innovative method that enables EDM machining of non-conductive ceramic material, named Assisting Electrode Electrical Discharge Machining (AEEDM). It combines electrical discharge machining with a hybrid assisting electrode. The aim of the study is to find the influence of pulse duration on surface roughness. For the set machining conditions, it was found that the surface roughness was increased by increasing the pulse duration. It should be emphasized that the supporting electrode method is used only in the electroerosion of electrically non-conductive materials.
FINITE ELEMENT METHOD ANALYSIS OF VARIOUS TOOTH ROOTS ON THE PINION OF CONNECTING HELICAL GEAR PAIRS HAVING COMPLEX TEETH BY CONSTANT MOMENT
Authors:   Department of Mechanical Engineering, University of Debrecen, Debrecen, Hungary, Bodzas Sandor
Published: December 2022

The aim of this study is the analysis of the mechanical parameters on the tooth roots having different fillet radiuses in case of helical gears having modified teeth. These gear pairs are widely used in different engineering constructions because of the better load transmission and the more silent noise. Consequently, the development researches are determinable in this field. Designing of one helical gear is needed for the analysis. After that the creation of its CAD model is essential. This gear pair is analyzed by different fillet radiuses on the tooth root of the pinion. All of the other geometric parameters are unchanged. The applied moments are also permanent for each experiment. After the FEM analysis the received results and graph will be evaluated.
Pendampingan Kader Dalam Pengembangan Perawatan Mandiri Pasien Diabetes Melitus Tipe 2 di Kelurahan Pedungan Kota Denpasar
Authors: Rasdini IGA Ari , Putrayasa IDP , Rahayu VM Endang S.P , Wedri Made
Published: December 2022

Tingginya kejadian Diabetes Melitus (DM ) berdampak pada semua aspek kehidupan pasien.Fokus utama dalam manajemen DM yaitu merubah pola hidup. Manajemen gaya hidup merupakan hal yang mendasar dalam perawatan DM seperti manajemen belajar sendiri, dukungan perawatan, aktivitas fisik, konseling merokok, dan perawatan psikososial .Diharapkan dengan perubahan pola hidup dapat meningkatkan kendali glikemik dan menurunkan komplikasi serta kematian. Kader kesehatan diberikan program pemberdayaan dengan sebagai motivator dan mentoring dalam melaksanakan perawatan mandiri secara komprehensif. Program utama dalam pengabdian kepada masyarakat yaitu pendampingan kader dalam pemberdayaan pasien DM tipe 2.Kegiatan tersebut diawali dengan pre test dengan memberikan pertanyaan dalam bentuk kuesioner. Materi diberikan oleh tim pelaksana sesuai dengan isi modul. Program pendampingan dilaksanakan setelah pemberian materi selesai. Pendampingan kader dilaksanakan dengan cara mendatangkan langsung pasien DM tipe 2 di Kelurahan Pedungan kota Denpasar. Mitra dibagi kedalam kelompok kecil yang beranggotakan 5-6 orang setelah diberikan pemaparan materi dan pendampingan terjadi peningkatan kemampuan mitra dalam pemberdayaan pasien DM tipe 2. Peningkatan tersebut terjadi secara bermakna yaitu 85,7 %, dengan kategori baik.
Manajemen Jalan Napas Untuk Mengatasi Masalah Ketidakefektifan Pola Napas Pada Pasien BBLR Di Ruang Soka RSUD Majenang
Authors: Anjani Pitaloka , Murniati Murniati , Suryani Roro Lintang
Published: December 2022

Masalah kesehatan yang mungkin muncul pada BBLR yaitu ketidakefektifan pola napas, hipotermia, gangguan nutrisi, serta belum sempurnanya organ-organ tubuh. Dari sekian masalah kesehatan yang muncul pada BBLR yang paling sering terjadi yaitu ketidakefektifan pola napas. Pada bayi dengan BBLR dibutuhkan asuhan keperawatan yang dilakukan secara komperhensif. Karya Tulis Ilmiah ini menggunakan rancangan studi kasus deskriptif yang menggambarkan asuhan keperawatan ketidakefektifan pola napas pada BBLR di Ruang Soka RSUD Majenang. Hasil penelitian adalah prioritas masalah keperawatan diagnosa keperawatan pada By. Ny. K yaitu ketidakefektifan pola nafas berhubungan dengan imaturitas otot-otot pernafasan. intervensi ketidakefektifan pola nafas mengacu pada NIC yang berfokus pada monitor pernafasan, manajemen jalan nafas dan pemberian obat, Implementasi yang dilakukan pada By. Ny. K meliputi memonitor tanda-tanda vital, memonitor saturasi oksigen, memposisikan pasien terlentang dan ekstensi, memberikan injeksi obat. Hasil akhir evaluasi pasien selama 3 hari mulai tanggal 16 Juni 2022 sampai 18 Juni 2022 yaitu untuk indikator frekuensi pernafasan mengalami peningkatan dari sedang menjadi ringan, saturasi oksigen juga mengalami peningkatan dari sedang menjadi ringan, dan retraksi dinding dada juga meningkat dari sedang menjadi ringan. Saran untuk penelitian ini adalah dengan Hasil penelitian ini diharapkan dapat meningkatkan kualitas perawat sebagai pemberi asuhan dan edukator, sehingga dapat dilakukan asuhan keperawatan yang tepat untuk meningkatkan kemampuan dalam memberikan perawatan yang optimal.
Penyuluhan dan Pelatihan Pembuatan Pupuk Organik Cair Pada Kelompok Tani Bilubahan
Authors: Pareira Magdalena Sunarty , Naikofi Kristina Irnasari , Ndua Natalia Desy Djata , Binsasi Yeremias
Published: December 2022

Kegiataan pengabdian masyarakat ini bertujuan ini untuk memberikan penyuluhan dan pelatihan kepada kelompok tani bilubahan Desa Tapenpah Kecamatan Insana Kabupaten Timor Tengah Utara dalam pembuatan pupuk organik cair dalam budidaya sayuran agar dapat meningkatkan pendapatan petani, serta dapat memberikan solusi yang tepat untuk mengurangi dampak negatif dari penggunaan pupuk kimia. Pupuk organik cair merupakan ekstraksi dari hasil pembusukan sampah organik yang mengandung unsur-unsur hara makro yakni nitrogen, fosfor, kalium dan C-organik yang digunakan tanaman untuk proses pertumbuhannya serta dapat meningkatkan produksi tanaman. Fungsi dari pupuk organik cair sebagai perangsang tumbuhan mulai tunas, buah dan biji, sedangkan daun dan batang bisa langsung menyerap secara langsung melalui stomata atau pori-pori yang ada pada permukaannya.
Commodification and Authenticity of Traditional Panji Bobung Mask Art in Putat Tourism Village, Patuk, Gunung Kidul, Yogyakarta
Authors: Subiyantoro Slamet , Kristiani Kristiani , Maryono Dwi , Fahrudin Dimas , Wijaya Yasin Surya
Published: December 2022

Panji has evolved into a well-known folklore and an art form that provides a source of income for its conservationists. The purpose of this research is to examine the commodification and authenticity of Topeng Panji art in Bobung as an effort to face the era of globalization and localize the nation's cultural arts. The research was conducted in Bobung, Putat, Patuk, Gunung Kidul, Yogyakarta. This study uses a qualitative descriptive approach with a single case strategy. Data is sourced from informants, venues and documents/archives collected with in-depth interview techniques, participatory observations, and content analysis. The validity of the data is tested by source triangulation techniques and informant reviews. Data analysis is conducted with interactive analysis models with data reduction, data display, and verification procedures. The results of this study show that the Commodification of Topeng Panji is based on the increasing and complex needs of the community where the source of income from agriculture and plantations is not enough. The authenticity or art of Topeng Panji tradition in Bobung is maintained by the community by introducing it to the younger generation from an early age.
Editorial
Authors: Henao Restrepo Darío
Published: December 2022

Nota editorial
Eros y Thánatos, componentes esenciales en la cuentística de Germán Espinosa
Authors: Vanegas Orfa Kelita
Published: December 2022

En este ensayo se trazan la relación de la muerte y el erotismo en la cuentística de Germán Espinosa. El sentir erótico que significa la inminencia del final de los tiempos, la idea de Thánatos como eje principal de la diferencia entre el ser humano y su entorno animal, la santidad  expresa en la negación y vivificada en la burla de las prohibiciones es un vector principal de la obra del autor colombiano, por eso la voluptuosidad de la cotidianidad del instinto negado establece las dimensiones de los personajes a mitad de camino del perfil-carácter de lo que pertenece al mundo que no merece relato y la gran dimensión del esperpento interior que justifica los desencadenantes de la ficción, esperpento interior relatado cual sujeto de leyenda: la muerte que seduce por la piel negada, carne de imaginación que al exponerse será el brillo de la hoz insalvable que entra en acción. Rodar de cabezas y finales de historias que no significan condena, sino quizá la completitud de la angustia tocada por los tintes de carnaval que le corresponden a la literatura
Critical Issues and Alternatives in South African Post-School Education and Training
Authors: Vally Salim , Motala Enver
Published: December 2022

Editorial
Antibacterial Activity of the Essential Oil Isolated from Origanum vulgare L. (Lamiaceae) Against Multi-Drug Resistant Bacteria
Authors: Mohsen Linda , Jaber Huda , Kame Widad M
Published: December 2022

Objective: The current study is designed to evaluate the activity of essential oil of Origanum vulgare against multi-drug resistant bacteria and both G+ and G- bacteria.
Material and Methods: O. vulgare essential oil was isolated by Clevenger-type apparatus according to the procedure described in the British pharmacopeia volume II. Five species of bacteria were used to evaluate the antibacterial activity of O. vulgare constituent in this study, Two Gram negative (Escherichia coli, and multidrug resistance Klebsiella pneumoniae) and three Gram positive bacteria (Streptococcus pneumonia, Staphylococcus aureus and Enterococcus faecalis). All bacteria isolated from different clinical sources. The stock solution (1-mg /16 mL) concentration had been prepared as follow: 1 mg of essential oil dissolved in 16 mL of (DMSO) dimethyl-sulfoxide. The serial dilution of 1-mg/mL was the following concentrations: 1000, 500, 250, 125 and 62.5 μg/mL were prepared for antibacterial activity by agar well diffusion. Ampicillin and Amoxicillin were used as positive control for all strains, while DMSO as negative control.
Conclusion: The essential oil of O. vulgare shows a good antibacterial activity against MDR bacteria as well as the other studied types of bacteria.
Formulation and Evaluation of Polyherbal Gel containing Ethanolic Extract used as Local Anesthetics in Oral Cavity
Authors: Sontakke Rupali , Singhal Rohit , Jain Neetesh K , Sontakke Shantanu
Published: December 2022

Conventional dosage forms frequently produce leakages and drip. There is a need for the development of innovative formulation technology that fulfills certain criteria such as desirable product dispersion throughout the system, retention for intended intervals, and adequate release of drug. These features can be achieved using bioadhesives based novel delivery systems. In-situ gelation is a process of gel formation at the site of application after the composition or formulation has been applied the site. Formulation and evaluation of one such bioadhesive based novel drug delivery system for an effective and patient friendly use of drug to formulated In-situ polyherbal gel. Piper betel L. (Pan, leaves) fam. Piperaceae; Spilanthesacmella Murr. (Akarkara, fruit), fam. Asteraceae; Foeniculum vulgare Mill. (Fennel, fruits) fam. (Umbelliferae); Eugenia caryophyllus (Spreng.) Bullock and S.G. Harrison (Clove, clove bud) fam. (Myrataceae) and Capsicum annum L. (Capsicum, fruits) fam. Solanaceae is medicinally important and is used as local anesthetics in oral cavity and these herbs were taken for formulation of polyherbal gel using Carbopol 934 and HPMC. The prepared formulation was evaluated, and the results were presented. The results indicate that the PHG-3 have satisfactory results when compared with other formulated PHG.
The Effect of Melatonin on C-reactive Protein, Serum Ferritin and D-Dimer in COVID-19 Patients
Authors: Hasan Zainab T , Al-Atrakji Mohammed Q. Y. M. A , Alsaaty Mohammad H , Abdulnafa Zaid D , Mehuaiden Ahmed K
Published: December 2022

Aim: To evaluate the effect of melatonin on C-reactive protein, serum ferritin and D–dimer level in adult patients with severe
coronavirus disease 2019 (COVID-19).
Method: This single center, prospective, randomized clinical trial conducted in Al-Shifaa hospital at Mosul, Iraq from
1st December 2020 to 1st June 2021 on 158 patients divided into two groups 82 patients in melatonin group (given 10 mg
melatonin) and 76 patients in control group. Then C-reactive protein (CRP), serum ferritin and D-dimer level were evaluated
and recorded at day 5, 11, 17 of symptoms.
Results: Totally, 82 patients in the intervention group and 76 patients in the control group have completed the treatment. In
comparison with the control group, the level of CRP, serum ferritin and D-dimer have significantly improved (P is less than 0.05) in melatonin group in the second week of infection.
Conclusions: The adjuvant use of melatonin in COVID-19 patients has a potential to improve CRP, ferritin, and D-dimer.
Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives
Authors: Al-Khazragie Zainab K , Al-Salami Bushra K , Al-Fartosy Adnan J. M
Published: December 2022

Two new series of N-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide and N-(4-acetyl-5-aryl-4,5-dihydro1,3,4-selenadiazol-2-yl)acetamide compounds (where aryl = 4-nitrophenyl, 4-hydroxy-3-methoxyphenyl, 3-ethoxy-4- hydroxyphenyl, 2-chloroquinolinyl, and 6-chloro-4-oxo-4H-chromenyl) were synthesized in good yields by heterocyclization of thiosemicarbazones (TSCs) and selenosemicarbazones (SSCs) with acetic anhydride, respectively. The new TSCs and SSCs compounds was prepared by condensation reaction of thiosemicarbazide and Selenosemicarbazide with aromatic aldehydes in acidic medium. The structures of newly synthesized 1,3,4-thiadiazoline (TDZs) and 1,3,4-selenadiazoline (SDZs) derivatives were characterized by the analytical and spectroscopic method such as IR, 1 H NMR, 13C NMR, mass spectra and elemental analysis. The purity of compound and evaluation of Rf value were determined by TLC. The toxicity of new compounds was assayed via the determination of their LD50 value by using Dixon’ s up and down method. The antibacterial activity of 1,3,4-thiadiazoline and 1,3,4-selenadiazoline compounds were tested in vitro against Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aeruginosa. Finally, antioxidant efficiency of all compounds were detected according to β-carotene bleaching method.
Protective Role of Kelakai (Stenochlaena Palustris) Extract on Malathion-induced Genotoxic: FTIR Spectroscopy Study
Authors: Suhartono Eko , Muthmainah Noor , Marisa Dona , Siahaan Salmon C.P.T , Komari Noer
Published: December 2022

Malathion is a genotoxic pesticide that destructs DNA. Many research have proven it, yet the mechanism has not been clear. That is the reason why this research needs to be conducted. This research used two groups, control, and two treatment group. The control group (P0) was 100 μL of Human Genomic DNA Female solution, while the treatment group (P1) was 100 μL of Human Genomic DNA Female solution which was added with 100 μL of 6 mM malathion solution. The other treatment group (P2) was 100 μL of Human Genomic DNA Female solution which was added with 100 μL of 6 mM malathion solution. Each group of solutions was incubated at 37oC for 48 hours. Then the absorbance was determined by FTIR. The content of the kelakai extract was determined by GC-MS. The results of the GC-MS analysis showed that the ethanolic extract of kelakai contained 6.1% hexadecanoic acid and 6.54% Neophytadiene. the percentage changes in the absorbance of guanine, thymine, cytocin, and adenine were significantly different in each group. So as deformation of the NH-groups in DNA bases. This means that kelakai extract can inhibit DNA damage.
Preparation and In-vitro Evaluation of Darifenacin HBr as Nanoparticles Prepared as Nanosuspension
Authors: Al-Obaidy Rafid A.R , Rajab Nawal A
Published: December 2022

Nanosuspension is a term that can be used to describe a colloidal dispersion of nanosized droplets of the drug in an aqueous medium with a size below 1 μm. Drug nanoparticles are one of the most significant methods to reduce the constituent part diameter and increase surface area, improving the dissolution and oral bioavailability of hydrophobic medicines, enhancing drug dissolution rate and bioavailability. Nanoparticles are produced using appropriate techniques for drug delivery applications and administered via various routes, including oral, topical, parenteral, ophthalmic, and pulmonary.
Overactive bladder (OAB) affects around 16% of adults and is more common as people become older. It causes a variety of symptoms, including urgency, incontinence, urine frequency, and nocturia. DH. It is newly drug used to treat complicated OAB. It has a higher selectivity for the bladder’s muscarinic receptors. After intravenous and immediate-release oral dose forms. It suffers from extensive first-pass metabolism with a short elimination half-life and ranging between three to four hours). The current research focused on creating an extended-release dosage form utilizing Eudragit RS100.
The solvent/anti-solvent precipitation method was used to make darifenacine nanoparticles. A certain quantity of medication was dissolved in a water-miscible solvent (methanol), then poured at a specific speed into water containing stabilizer on a magnetic stirrer for a 1/2-hour; after that, the resulted product was sonicated at 37°C for 15 minutes.
The physicochemical interaction among medication with additives was explored utilizing fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetric (DSC). The particle size and zeta potential of the generated nanosuspension were calculated.
Microneedles as A Magical Technology to facilitate Transdermal Drug Delivery: A Review Article
Authors: Salih Omar S , Al-akkam Entidhar J
Published: December 2022

Skin drug administration is the method used to provide drugs for local or systemic therapy, which is recognized for clinical usage. It is the third-largest method of medication delivery, after only intravenous administration and oral administration. Using a transdermal delivery method makes the administration easy, and blood concentration and adverse effects can be reduced. A microneedle is a micron-sized needle with a short height of no more than 500 micrometers and a width of no more than 50 micrometers. The needle comes into contact with the epidermal layer of the skin before it gets to the dermal layer, where there is no discomfort. Several materials, such as metals, inorganic, and polymer materials, are used to create microneedles. All different types of microneedles are employed in different scientific disciplines. In recent years, microneedles have been utilized as a drug delivery method to carry pharmaceuticals, genetic codes, proteins, and vaccinations. In chemotherapy, diagnostics, treatment, and immunotherapy, microneedles were utilized.
Synthesis and Biological Activity of New Derivatives of Thiazolidine and Oxazepine-Linked to Pyridine Moieties
Authors: Sahb Mohaned M. , Kadam Zeina M.
Published: December 2022

This research includes reaction and condensation between substituted 4-aminopyridine and 4-(N, N-dimethyl amino benzaldehyde) to produce Schiff base derivative (3), the compound (3) was selected to react with a different compound such as Thioglycolic acid, Phthalic anhydride, and maleic anhydride, to produced new ring of Thiazolidine derivatives and oxazepine derivatives structures (4,5,6,7,8,9,10,11,12), respectively. The final compound was characterized the structure by Fourier transform-infrared spectroscopy, H-Nuclear magnetic resonance (H-NMR) in addition to the Carbon, Hydrogen, Nitrogen (CHN) analyzer. Biological activity has been considered for the final structures and achievements of multi drugs.
Formulation and Evaluation of Antibacterial Gel containing Ethanol Extract of Thorns of Bombax ceiba
Authors: Chauhan Prashant . , . Monika .
Published: December 2022

Purpose: Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes. Methods: Agar well diffusion method were employed for the purpose. Results: Gel formulation of different concentrations of extract were formulated that is 2, 4, 6 and 8%, respectively and antibacterial activity of the gels were measured against the bacteria S. aureus and P. acnes. In this clindamycin gel was used as the standard for comparative analysis. It was concluded from evaluation results that a formulation of 8% showed better antibacterial activity than other formulated preparations. In addition to this, gel formulations were evaluated considering various parameters such as pH, appearance, viscosity, spreadability and homogeneity and the result were calculated. Conclusion: The ethanol thorn extract of B. ceiba possess good antibacterial property against the S. aureus and P. acnes. It also contains various phytoconstituents which may be helpful in various health-related problems.
Mebendazole Loaded Nanoparticles for Lung Cancer Therapy
Authors: Anaaa Heba . , Muhanab Frezah . , El-Tanania Mohamed . , Madic Razan . , Kerfanc Rahmeh .
Published: December 2022

Lung cancer is the leading cause of cancer mortality. Lung cancers are classified into two types based on their microscopic appearance: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Many individuals are first diagnosed at stage III or IV, when their prognosis is bleak. Non-small cell lung cancer is a lethal and incurable illness that can be treated with surgery, chemotherapy, radiation therapy, targeted therapy, or a combination of therapies. Targeted treatment focuses on particular abnormalities seen in cancer cells, such as the Epidermal growth factor receptor (EGFR) mutation. The T 790M mutation in the EGFR’s tyrosine kinase domain causes acquired resistance to first-generation EGFR TKIs, mebendazole. As a result, combining diverse targeted therapeutic drugs not only improves treatment outcomes but can also be a more effective preventer of acquired resistance improvement. Loaded drug Nanoparticles ZSM-5 and SBA-16 were utilized as targeted treatment, and their stability and loading % were determined using multiple methods, including infrared, X-Ray Diffraction, TGA, and HPLC. The therapy was used in in-vitro cell culture investigations such as the MMT assay, colony assay, and migration assay. The results showed that the loaded drug nanoparticles had a lower IC50 than the free drug mebendazole we utilized, indicating that the nanoparticles improved therapy and reduced medication dosage.
Design, Formulation, Optimization and In-vitro Evaluation of Colon-targeted Tablet Utilizing Polymer Isolated from Artocarpus heterophyllus
Authors: Kumar Lavi . , Singh Bhupendra . , Saini Geetanjali . , Sharma Ankita . , Sharma Pooja . , Thakur Vandana . , Thakur Nisha . , Vyas Manish .
Published: December 2022

Objective: The objective of the present study is to formulate, optimize, and evaluate the colon-targeted oral Tablet by utilizing the polymer obtained from Artocarpus heterophyllus. Ibuprofen was used as a model drug in the study. Methods: The Polymer was extracted from the fresh fruits of Artocarpus heterophyllus and subjected to identification and characterization. The formula of the Tablet was optimized using 3 factors 3 levels Box-Behnken design (Design Expert Software). The colon-targeted Tablets were then formulated and coated with pH-dependent polymer to avoid release in the upper gastrointestinal tract. Results: Pre-compression and post-compression characteristics of the Tablet were studied which were within the standard limits.
Efficacy of Gold and Nickel on the Anticancer Activity and Physical Properties of Pemetrexed Loaded on Fullerene C60 Buckysomes
Authors: Mahdi Ali I. A. , Maraie Nidhal K. , Dawood Ashour H.
Published: December 2022

Objective: This study aims to create a new delivery system for pemetrexed, employing a metal-C60 fullerene combination for the first time. Additionally, a lung cancer cell line study will be used to examine the impact of this combination on the release, behavior, and drug’s cytotoxicity. Methods: To utilize a laser to irradiate hydrocarbons, fullerene C60 (Buckysomes) was produced and then nanosized by adding different volumes of isopropyl alcohol and ultrasonication. Gold Nanoparticles (AuNPs) and nickel nanoparticles (NiNPs) were also prepared each one separately and added to the previous mixture together with Pemetrexed (PMX) with further ultrasonication for 20 minutes. The mixture is kept in the refrigerator for 20 hours and then filtered. The precipitate was dried and characterized for particle size, invitro release, and anticancer activity in comparison to pemetrexed loaded on C60 fullerene previously prepared in our laboratory. Results: The evaluation techniques revealed the successful loading of pemetrexed on metals- fullerene C60 nanocarrier, SG10 was the optimum sample with % of yield reach to 95.36. The release profile shows that the percentage release of pemetrexed after 240 minutes is equal to 40% from pure PMX, while the release after 240 minute was found to be 87.8 % from pemetrexed loaded gold nanoparticles (AuNPs) fullerene C60 nanocarrier (SG10), while NiNPs not significantly improved the release profile of Pemetrexed from Pemetrexed loaded NiNPs – fullerene (SN7). Pemetrexed loaded on gold nanoparticles (AuNPs), when compared to pure PMX (3.1 M) and SN7 (11.5 M), fullerene nanocarrier (SG10) exhibits a lower IC50 (1.55 M) and a greater cytotoxic effect (high IR percent) on A549 cancer cells. Pemetrexed’s cytotoxicity in A549 was enhanced after being loaded onto gold nanoparticles (AuNPs)-fullerene nanocarriers (90.4% cell death for SG10) as opposed to pure drug (60% cell death). This finding suggests that the loading process enhanced the drug’s cytotoxic activity for the tumor cells, which may have sped up the onset of action (30% cell death after 24 hours). Conclusion: This study successfully prepared Metals- fullerene C60 Buckysomes loaded with pemetrexed utilizing gold and nickel, which may serve (especially Au- fullerene) as a suitable nanocarrier for pemetrexed, resulting in an improvement to solubility, the release pattern, and cytotoxicity.
Phytochemical Study of Iraqi Cydonia oblonga Miller Fruit
Authors: Obaid Noor S. , Al-Ani Widad M.
Published: December 2022

Quince (Cydonia oblonga) fruit has a lot of phytochemicals that draw the attention of many researchers nowadays for its important medicinal values. This study concerns the identification and isolation of two flavonoids (Astragalin) flavonol glycoside and (Isorhamnetin) from fruit ethyl acetate extract of Iraqi cultivated Cydonia oblonga. The identification was carried out by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) analysis techniques. The yield of isolated compound was (1.6 and 1.3 %) for astragalin and isorhamnetin, respectively. This was achieved by using preparative thin layer chromatography glass plate (20×20) cm. This is followed by structure elucidation of isolated compounds through fourier transform infrared (FT-IR), ultraviolet (UV), nuclear magnetic resonance (1HNMR) and carbon-13 nuclear magnetic resonance (13CNMR). analysis procedures.
Synthesis of New Azo Compound and its Application for Spectrophotometric Determination of Sulfamethoxazole and Extraction using Cloud Point Extraction
Authors: Thani Mohammed Z. , Dadoosh Safaa A. , Fahad Abbas S. , Abdullah Asmaa M. , Fahad Younus S.
Published: December 2022

In this study, we synthesized new sulfamethoxazole azo derivative by converted the SMZ drug to diazonium salt and coupling it with salbutamol in the alkaline medium to form an orange water-soluble azo dye that has a maximum absorption at λmax 450 nm. This reaction was used in the spectrophotometric determination of SMZ drug. It was obeyed to beer-lambert,s low over concentration between (10–100 mg.L-1) with LOD (0.507 mg.L-1), LOQ (1.5 mg.L-1) and molar absorptivity (2332.2 L.mol-1.cm-1). The approach indicated great sensitivity for the assessment of chosen medicine. Another method, a new cloud point extraction approach, was successfully used to extract the SMZ medication in its pure form as well as in pharmaceutical formulations. Due to its features and structure, non-ionic surfactant, also known as 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy] ethanol, was chosen as the green extraction solvent in this study. The effect of several parameters on the CPE of Sulfamethoxazole, including as the type and volume of surfactant, salt, temperature, and incubation duration, was thoroughly researched, and a set of ideal conditions was established. The correlation coefficient (R2) for the calibration curve was found to be 0.9956. The limit of detection (LOD), limit of quantitation (LOQ) and molar absorptivity were 0.122 mgL-1, 0.403 mg.L-1 and 11319.41 L.mol-1.cm-1, respectively.
Docking Study of Selected Phytoconstituents with Acetylcholine Esterase and BChE for its Anti-alzheimers Activity
Authors: Banpure Sonali G. , Chopade Vitthal V.
Published: December 2022

In this research, we have observed known constituents from different plants and perform docking of these phytoconstituents with different AChE & BChE PDBs. It found good binding with Different PDBs. For the docking study, we selected 11 PDBs which include 4TPK, 4AQD, 6EP4, 1H22, 4EY5, 2XQF, 6O4X, 6O4W, 4BDT, 6EQQ, 1B41.
The efficacy of topical adipose mesenchymal stem cell-conditioned medium versus framycetin gauze dressing in chronic plantar ulcer of leprosy: A randomized controlled trial
Authors: Alinda Medhi Denisa , Christopher Paulus Mario , Listiawan Muhammad Yulianto , Endaryanto Anang , Suroto Heri , Rantam Fedik Abdul , Hendradi Esti , Notobroto Hari Basuki , Prakoeswa Cita Rosita Sigit
Published: December 2022

Background

Wound healing shows a unique interaction of several cells, growth factors and cytokines. The healing of chronic plantar ulcer of leprosy is influenced by various factors, one of which is the concentration of growth factors and cytokines related to the pathogenesis of impaired wound healing. Growth factors and cytokines can be found in the secretome of adipose mesenchymal stem cells.

Aim

To compare the effectiveness of topical adipose mesenchymal stem cell-conditioned medium and framycetin gauze dressing only on the healing of chronic plantar ulcer of leprosy.

Methods

In this randomised controlled trial, 32 patients with chronic plantar ulcer of leprosy were recruited. After detailed clinical and initial debridement, patients were randomised to two groups to receive either topical adipose mesenchymal stem cell-conditioned medium (n = 16) or framycetin gauze dressing only (n = 16) applied every three days for up to eight weeks, following which the ulcer size, adverse reactions and complications if any were monitored weekly.

Results

Healing percentage increased each week in all groups. Statistical differences between groups (P < 0.05) were observed from week 2 onwards for ulcer mean size reduction and from week 3 onwards for ulcer mean depth reduction. There were no adverse reactions or complications.

Limitations

Off-loading on subjects were not performed.

Conclusion

Adipose mesenchymal stem cell-conditioned medium is a potential therapeutic agent in the management of chronic plantar ulcer of leprosy.
Risk factors of deterioration in patients of head injury with non-operative management on first neurosurgical consultation
Authors: Churiwala Jayati , Garale Mahadeo Namdeo , Kawale Juhi , Dandpat Saswat Kumar , Mahore Amit
Published: December 2022

Objectives:

In most of the emergency trauma intensive care units (ICUs) of India, neurosurgical opinion is sought for patients presenting with head trauma after earliest possible resuscitation to determine the further line of management. This study aimed to identify common risk factors, leading to neurological deterioration in conservatively managed patients of traumatic brain injury (TBI).

Materials and Methods:

This retrospective study analyzed patients admitted with acute TBI and traumatic intracranial hematoma under emergency trauma care ICU who did not require neurosurgical operation within 48 h of trauma. The recorded data were analyzed to determine the predictors of neurological deterioration using univariate and binary logistic regression analysis in SPSS-16 software.

Results:

Medical records of consecutive 275 patients of acute TBI presenting to the emergency department were studied. One hundred and ninety-three patients were afflicted with mild TBI (70.18%), 49 patients had moderate TBI (17.81%), and 33 had severe TBI (12%). In the outcome, 74.54% of patients were discharged, and operative decision was made on 6.18% of patients and 19.27% died. Severe TBI is the independent predictor of neurological deterioration during their stay in ICU. Progressive hemorrhagic injury (PHI) showed neurological deterioration in 86.5% of patients. Systemic inflammatory response syndrome (SIRS) was present in 93.5% of patients who had deteriorated neurologically. Dyselectrolytemia was the biochemical derangements seen in 24.36% of cases.

Conclusion:

This study revealed severe TBI, PHI, and SIRS to be strong and independent risk factors of neurological deterioration.
VINNYTSIA COUNTY IN THE POST-REFORM PERIOD (1862 – 1872): FEATURES OF DEMOGRAPHY AND SOCIO-ECONOMIC DEVELOPMENT
Authors:   Khmelnytskyi University of Economics and Entrepreneurship, Mulyar Anatoly
Published: December 2022

The purpose of the study based on documentary sources is to analyze the demographic and socio-economic status of the Vinnytsia district of Podilsk province in the post-reform period (1862 - 1872). In the example of a small Podilskyi district, we want to trace the process of development of capitalist relations that originated and began to develop after the abolition of serfdom in the Russian Empire. The research methodology is based on historical, systematic science principles. In the process of writing, comparative-historical, systemic, and typological methods were used. The scientific novelty is to ask the question of the need to study the socio- economic development and demographic state of Ukrainian lands in the post- reform period of the Russian Empire based on archival sources and documents. Conclusions. Thus, in the post-reform period (1862 - 1872) the Vinnytsia district of Podilsk province remained an agrarian region where no capitalist transformations occurred. Commodity-monetary relations, which are observed in the studied territory, are local in nature, and apparently arose until 1861. Most of them are related to agricultural production and the sale of grown, rarely processing. The life and everyday activities of the local population have not changed.
DYNAMIC VISCOSITY OF SUPERCRITICAL WATER FLOWING IN HEATED CHANNELS
Authors:   Institute of Engineering Thermophysics of NAS of Ukraine, Fialko Nataliia , Meranova Nataliia ,   Institute of Engineering Thermophysics of NAS of Ukraine, Sherenkovskiy Julii ,   Institute of Engineering Thermophysics of NAS of Ukraine, Aleshko Sergiy ,   Institute of Engineering Thermophysics of NAS of Ukraine, Khmil Dmytro ,   Institute of Engineering Thermophysics of NAS of Ukraine, Sharaevsky Igor ,   Institute for Safety Problems of Nuclear Power Plants of NAS of Ukraine, Zimin Leonid ,   Institute for Safety Problems of Nuclear Power Plants of NAS of Ukraine, Vlasenko Tetiana ,   Institute for Safety Problems of Nuclear Power Plants of NAS of Ukraine, Kutnyak Olha ,   Institute of Engineering Thermophysics of NAS of Ukraine, Chekharovska Maryna ,   Institute of Engineering Thermophysics of NAS of Ukraine
Published: December 2022

The data of the CFD analysis of the fields of dynamic viscosity of supercritical water in round channels for different values of the heat fluxq supplied to the wall are presented.
CIRCUMSTANCES THAT INCLUDED IN THE SUBJECT OF PROOF AND THE LIMITS OF THE ACTIVITY OF THE DEFENCE PARTY IN ESTABLISHING SUCH CIRCUMSTANCES
Authors:   Yaroslav Mudryi National Law University, Berezhnyi Oleksandr
Published: December 2022

The article explores problematic issues during the establishment of circumstances included in the subject of proof and the procedural possibilities of the defense party in the process of proof in criminal proceedings.
USE OF NEURAL NETWORKS TO DIAGNOSE CHEST DISEASES ON RADIOGRAPHS
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Nerus Vladyslav
Published: December 2022

In this work, machine and deep learning methods were considered and analyzed for detecting abnormalities on chest X-rays.
THE IMPACT OF INFORMATION TECHNOLOGY ON THE ACTIVITIES OF THE ENTERPRISE
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Nabukhotna Yuliia , Zhygalkevych Zhanna ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
Published: December 2022

This paper investigates the role and impact of modern information technology on the activities of the enterprise. The existing scientific approaches to defining the concept of information technology (IT) are analyzed, and its own definition is given, according to which IT is the most modern information management tool that allows users and employees to collect, accumulate, process, organize, store and disseminate information in a convenient way. It is emphasized that modern management information technologies and systems allow to more quickly deliver important economic information to different levels of decision-making, rationally process it and systematize it. The main reasons that encourage the introduction of modern information technologies at enterprises are indicated. The logical and structural model of the mechanism of introduction of information technologies at modern enterprises is presented. The process of measuring informatization, which occurs on the basis of the scale of implementation of information technology in the management system of the organization is described. The perspectives of Ukraine to rise to the European level of informatization are outlined. The influence of modern information technologies both on the change of strategic plans of the enterprise and on the modernization of the work culture in general is revealed. It is substantiated that, first of all, the introduction of information technologies at the enterprise will solve the issues of delimitation of management zones, rationalization of the system of evaluation indicators, ensuring the relationship between operational, accounting and statistical accounting, rationalization of information flows, etc. The list of software for small and medium enterprises is given. And also, the criteria of economic, organizational, managerial, marketing and social effects of enterprise informatization are defined. It is determined that today a promising trend is the growing integration of modern information systems with analytical tools to improve the management of all types of business and business modeling.
INCREASING THE ENERGY EFFICIENCY OF GAS-FIRED BOILER UNITS OF MUNICIPAL THERMAL ENERGY
Authors:   Institute of Engineering Thermophysics of NAS of Ukraine, Fialko Nataliia , Presich Georgii ,   Institute of Engineering Thermophysics of NAS of Ukraine, Navrodska Raisa ,   Institute of Engineering Thermophysics of NAS of Ukraine, Gnedash Georgii ,   Institute of Engineering Thermophysics of NAS of Ukraine, Novakivskii Maksym ,   Institute of Engineering Thermophysics of NAS of Ukraine
Published: December 2022

Various modifications of heat-recovery technologies are presented to improve the thermal performance of gas-fired boilers of small and medium power.
USE OF CULTURAL HERITAGE OBJECTS OF UKRAINE FOR TOURISM DEVELOPMENT AND EXCURSION ACTIVITIES
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Pokolodna Mariia , Smal Anastasiia ,   O. M. Beketov National University of Urban Economy in Kharkiv, Yatsiuk Mykola ,   O. M. Beketov National University of Urban Economy in Kharkiv
Published: December 2022

Ukraine has a significant potential of cultural heritage objects of various nature, with varying degrees of involvement and rationality of use in tourism and excursion activities, which requires research and generalization of the accumulated experience. In Ukraine, the term cultural heritage refers to the entire set of cultural heritage objects inherited by humanity from previous generations. Currently, these registers include 1,155 objects of national significance and 13,931 objects of local significance. In terms of the number of monuments of national importance, the AR of Crimea, the city of Kyiv, Chernihiv, Zakarpattia, and Cherkasy regions are among the top five. On the other hand, Dnipropetrovsk Sumy, Kharkiv Poltava, and Odesa regions are leading in terms of the number of monuments of local importance. 47 elements have been added to the National List of Elements of the Intangible Cultural Heritage of Ukraine. All objects can have different statuses: local, state/national and international. The latest status of the objects is confirmed and provided by UNESCO and described in the Convention on the Protection of World Cultural and Natural Heritage, to which Ukraine has joined. Since then, only 6 objects of cultural, 1 natural and 4 intangible heritage have this status in the state. A comparison was made of the number of objects included in the UNESCO World Heritage List in Ukraine with other European countries. An analysis of the level of use of these objects for the purposes of tourism development and excursion activities was carried out. The range of use of cultural heritage objects is limited in a certain way and is determined by the adopted legislation, in particular in Ukraine it is the Law "On the Protection of Cultural Heritage", which regulates the use of cultural heritage objects in public life, maintenance and use of monuments, sightseeing visiting sights, and also determines directions of possible use of sights. Among the most effective for the development of tourism and excursion activities, the authors identify museification and adaptation. Based on the analysis, the authors offer a number of universal proposals for the intensification of the attraction of cultural heritage objects for the purposes of tourism development and excursion activities.
FORECASTING STOCK MARKET FOOD INDEX USING COMMODITY FUTURES QUOTES
Authors:   National University of Life and Environmental Sciences of Ukraine, Symonenko Olena , Symonenko Dmytro ,   University of Vienna
Published: December 2022

This article is devoted to testing whether commodity futures can act as tools to predict price fluctuations of commodity indices. We decided to choose WIG-food index and leading commodity futures since they are interconnected. Companies included in our index use commodities in their operations. While we managed to find comparable articles regarding financial market forecasts using different indices, we did not find any opportunities to predict niche indices like WIG-food in our example. Therefore, our article may act as clarification of whether it is possible to use machine learning algorithms combined with basic regression to predict commodity indices price fluctuations. The prediction of stock price movements has long been an intriguing topic of financial research. Particularly prominent ways of predicting a stock price trend include using stocks past performance or using sentiment analysis. However, a certain level of criticism must be applied to these methods. Using past performance creates a certain degree of isolation that leaves out important information carried out by other entities and makes the prediction result vulnerable to local perturbations. Before, we tested whether the relationship between these variables exists to implement machine learning algorithms in price forecasting. Our study consists of Introduction, where were familiarize the reader with the topic; a Methodology, where we describe data collection principles and reasoning for conducting the research, as well as describing machine learning algorithms behind our analysis; Results, where we present the outcomes of our models and a Conclusion. We proposed the use of data collected from different global financial markets with machine learning algorithms to predict stock index movements. In this project, we have attempted to forecast stock price trends using machine learning techniques LSTM. Before we ran basic regression using Keras to derive the reasonability of applying the LSTM model. Regression results showed that commodities included in the model were far from perfection and we managed to achieve 48% accuracy of regression predictive power using commodity futures as features. Therefore, we excluded them from the LSTM model since they turned out to be not credible variables to apply in the machine learning algorithm.
ANALYSIS AND IMPROVEMENT OF ANALYTICAL ACCOUNTING OF INCOME AND COSTS IN THE RAILWAY FIELD
Authors:   University of Customs and Finance, Babenko Lyudmila , Vasylieva Valentyna ,   University of Customs and Finance, Hryhorieva Anzhelika ,   University of Customs and Finance
Published: December 2022

The article examines the approach to the analytical accounting of the costs of the main operating activities of the railway industry in order to determine the cost of services and works on the example of the structural division of the Dnipro Regional Branch of Prydniprovska Zaliznytsia JSC Ukrzaliznytsia. The nature of the occurrence of costs and revenues at enterprises of the railway industry and the system of cost management have been studied. The search for possible ways to improve and optimize the accounting of expenses and income by the main type of operational activity of the enterprise was carried out. Problematic issues regarding the methodological aspects of reflecting income and expenses in accounting are identified and ways of their improvement are proposed. The article revealed that it is worth paying attention to a detailed analysis of the sources of income and expenses for the effective use of production resources, the formation of management reporting and the adoption of timely and correct management decisions.