bluuebunny/crossref_metadata_2025 huggingface dataset:
Carotid Reservoir Pressure Decrease After Prolonged Head Down Tilt Bed Rest in Young Healthy Subjects Is Associated With Reduction in Left Ventricular Ejection Time and Diastolic Length
Authors: Palombo Carlo , Kozakova Michaela , Morizzo Carmela , Losso Lorenzo , Pagani Massimo , Salvi Paolo , Parker Kim H. , Hughes Alun D.
Published: March 2022

Background

The arterial pressure waveform reflects the interaction between the heart and the arterial system and carries potentially relevant information about circulatory status. According to the commonly accepted ‘wave transmission model’, the net BP waveform results from the super-position of discrete forward and backward pressure waves, with the forward wave in systole determined mainly by the left ventricular (LV) ejection function and the backward by the wave reflection from the periphery, the timing and amplitude of which depend on arterial stiffness, the wave propagation speed and the extent of downstream admittance mismatching. However, this approach obscures the ‘Windkessel function’ of the elastic arteries. Recently, a ‘reservoir-excess pressure’ model has been proposed, which interprets the arterial BP waveform as a composite of a volume-related ‘reservoir’ pressure and a wave-related ‘excess’ pressure.

Methods

In this study we applied the reservoir-excess pressure approach to the analysis of carotid arterial pressure waveforms (applanation tonometry) in 10 young healthy volunteers before and after a 5-week head down tilt bed rest which induced a significant reduction in stroke volume (SV), end-diastolic LV volume and LV longitudinal function without significant changes in central blood pressure, cardiac output, total peripheral resistance and aortic stiffness. Forward and backward pressure components were also determined by wave separation analysis.

Results

Compared to the baseline state, bed rest induced a significant reduction in LV ejection time (LVET), diastolic time (DT), backward pressure amplitude (bP) and pressure reservoir integral (INTPR). INTPR correlated directly with LVET, DT, time to the peak of backward wave (bT) and stroke volume, while excess pressure integral (INTXSP) correlated directly with central pressure. Furthermore, Δ.INTPR correlated directly with Δ.LVET, and Δ.DT, and in multivariate analysis INTPR was independently related to LVET and DT and INTXSP to central systolic BP.

Conclusion

This is an hypothesis generating paper which adds support to the idea that the reservoir-wave hypothesis applied to non-invasively obtained carotid pressure waveforms is of potential clinical usefulness.
Role of the Basolateral Na+/H+ Exchanger-2 (NHE2) in Ionocytes of Seawater- Acclimated Medaka (Oryzias latipes)
Authors: Liu Sian-Tai , Horng Jiun-Lin , Lin Li-Yih
Published: March 2022

Ionocytes in the skin and gills of seawater (SW) fishes are responsible for acid-base regulation and salt secretion. Na+/H+ exchangers (NHEs) are considered the major acid (H+)-secreting transporters in ionocytes of SW fishes. However, the subcellular localization and function of a specific NHE isoform (NHE2) have never clearly been revealed. In this study, we cloned and sequenced NHE2 from an SW-acclimated medaka (Oryzias latipes) and examined its functions in medaka embryos. A phylogenetic analysis showed that the evolutionary relationships of mammalian NHE2 and NHE4 are close to those of fish NHE2. A gene structure analysis showed that tetrapod NHE4 might be a tandem duplication of fish NHE2. Immunohistochemistry with a medaka-specific antibody localized NHE2 to the basolateral membrane of ionocytes. Lost-of-function experiments with photo-activated morpholino oligonucleotides showed that both H+ and Cl– secretion by ionocytes were suppressed in NHE2-knockdown embryos, suggesting that the basolateral NHE2 facilitates acid and salt secretion by ionocytes of medaka in seawater.
Weed Density Extraction Based on Few-Shot Learning Through UAV Remote Sensing RGB and Multispectral Images in Ecological Irrigation Area
Authors: Wang Shubo , Han Yu , Chen Jian , He Xiongkui , Zhang Zichao , Liu Xuzan , Zhang Kai
Published: March 2022

With the development of ecological irrigation area, a higher level of detection and control categories for weeds are currently required. In this article, an improved transfer neural network based on bionic optimization to detect weed density and crop growth is proposed, which used the pre-trained AlexNet network for transfer learning. Because the learning rate of the new addition layer is difficult to tune to the best, the weight and bias learning rate of the newly added fully connected layer is set with particle swarm optimization (PSO) and bat algorithm (BA) to find the optimal combination on the small data set. Data are transported to the convolutional neural network (CNN) by collecting red-green-blue (RGB) and 5-band multispectral images of 3 kinds of weeds and 3 kinds of crops as data sets, through cutting, rotating, and other operations. Finally, 6 kinds of classifications are implemented. At the same time, a self-constructed CNN based on model-agnostic meta-learning (MAML) is proposed in order to realize the learning of neural networks with small sample and high efficiency, and its accuracy is verified in the test set. The neural networks optimized by two bionic optimization algorithms are compared with the self-constructed CNN based on MAML and histogram of oriented gradient + support vector machine (HOG + SVM). The experimental results show that the combination of learning rate through BA is the best, and its accuracy can reach 99.39% for RGB images, 99.53% for multispectral images, and 96.02% for a 6-shot small sample. The purpose of the classification proposed in this article is to calculate the growth of various plants (including weeds and crops) in the farmland. And various plant densities can be accurately calculated through the plant density calculation formula and algorithm proposed in this article, which provides a basis for the application of variable herbicides by experimenting in different farmlands. Finally, an excellent cycle of ecological irrigation district can be promoted.
Exploring Genomic Variations in Nematode-Resistant Mutant Rice Lines
Authors: Dash Manoranjan , Somvanshi Vishal Singh , Godwin Jeffrey , Budhwar Roli , Sreevathsa Rohini , Rao Uma
Published: March 2022

Rice (Oryza sativa) production is seriously affected by the root-knot nematode Meloidogyne graminicola, which has emerged as a menace in upland and irrigated rice cultivation systems. Previously, activation tagging in rice was utilized to identify candidate gene(s) conferring resistance against M. graminicola. T-DNA insertional mutants were developed in a rice landrace (acc. JBT 36/14), and four mutant lines showed nematode resistance. Whole-genome sequencing of JBT 36/14 was done along with the four nematode resistance mutant lines to identify the structural genetic variations that might be contributing to M. graminicola resistance. Sequencing on Illumina NovaSeq 6000 platform identified 482,234 genetic variations in JBT 36/14 including 448,989 SNPs and 33,245 InDels compared to reference indica genome. In addition, 293,238–553,648 unique SNPs and 32,395–65,572 unique InDels were found in the four mutant lines compared to their JBT 36/14 background, of which 93,224 SNPs and 8,170 InDels were common between all the mutant lines. Functional annotation of genes containing these structural variations showed that the majority of them were involved in metabolism and growth. Trait analysis revealed that most of these genes were involved in morphological traits, physiological traits and stress resistance. Additionally, several families of transcription factors, such as FAR1, bHLH, and NAC, and putative susceptibility (S) genes, showed the presence of SNPs and InDels. Our results indicate that subject to further genetic validations, these structural genetic variations may be involved in conferring nematode resistance to the rice mutant lines.
Dry Season Transpiration and Soil Water Dynamics in the Central Amazon
Authors: Spanner Gustavo C. , Gimenez Bruno O. , Wright Cynthia L. , Menezes Valdiek Silva , Newman Brent D. , Collins Adam D. , Jardine Kolby J. , Negrón-Juárez Robinson I. , Lima Adriano José Nogueira , Rodrigues Jardel Ramos , Chambers Jeffrey Q. , Higuchi Niro , Warren Jeffrey M.
Published: March 2022

With current observations and future projections of more intense and frequent droughts in the tropics, understanding the impact that extensive dry periods may have on tree and ecosystem-level transpiration and concurrent carbon uptake has become increasingly important. Here, we investigate paired soil and tree water extraction dynamics in an old-growth upland forest in central Amazonia during the 2018 dry season. Tree water use was assessed via radial patterns of sap flow in eight dominant canopy trees, each a different species with a range in diameter, height, and wood density. Paired multi-sensor soil moisture probes used to quantify volumetric water content dynamics and soil water extraction within the upper 100 cm were installed adjacent to six of those trees. To link depth-specific water extraction patterns to root distribution, fine root biomass was assessed through the soil profile to 235 cm. To scale tree water use to the plot level (stand transpiration), basal area was measured for all trees within a 5 m radius around each soil moisture probe. The sensitivity of tree transpiration to reduced precipitation varied by tree, with some increasing and some decreasing in water use during the dry period. Tree-level water use scaled with sapwood area, from 11 to 190 L per day. Stand level water use, based on multiple plots encompassing sap flow and adjacent trees, varied from ∼1.7 to 3.3 mm per day, increasing linearly with plot basal area. Soil water extraction was dependent on root biomass, which was dense at the surface (i.e., 45% in the upper 5 cm) and declined dramatically with depth. As the dry season progressed and the upper soil dried, soil water extraction shifted to deeper levels and model projections suggest that much of the water used during the month-long dry-down could be extracted from the upper 2–3 m. Results indicate variation in rates of soil water extraction across the research area and, temporally, through the soil profile. These results provide key information on whole-tree contributions to transpiration by canopy trees as water availability changes. In addition, information on simultaneous stand level dynamics of soil water extraction that can inform mechanistic models that project tropical forest response to drought.
Harnessing the Potential of Wheat-Pea Species Mixtures: Evaluation of Multifunctional Performance and Wheat Diversity
Authors: Timaeus Johannes , Weedon Odette Denise , Finckh Maria Renate
Published: March 2022

Species mixtures and heterogeneous crop populations are two promising approaches for diversified ecological cropping systems with increased resilience and reduced dependency on external inputs. Inter- and intraspecific diversity were evaluated in combination using 15 wheat (Triticum aestivum) entries, including line cultivars and heterogeneous populations (HPs), from central Europe and Hungary and one winter pea cultivar under organic conditions. Monocultures and wheat mixtures were evaluated multi-functionally for yield, quality, land use efficiency, crop protection, and wheat entry traits. Mixtures increased cereal grain quality, weed suppression, resource use efficiency, yield gain, and reduced lodging. Effects were stronger in 2018/19, which were characterized by dry and nutrient-poor conditions than in 2019/20 when nutrient levels were higher. Wheat entries varied considerably in protein content and yield in both mixtures and monocultures. Under higher nutrient availability, entry-based variation was reduced in both systems, and peas were suppressed. Because of low disease pressure, the wheat entries varied little in terms of disease protection services, and mixture effects on the disease were low. The multi-criteria framework identified stability of yield, yield gains, and quality under high environmental variability of mixtures as clear agronomic advantages with HPs being considerably more stable than line cultivars. Some line cultivars outperformed the HPs in either protein content or yield across environments but not both simultaneously. Trait analysis revealed a possible link between harvest index and reduced competition in mixtures, which can increase yield performance in specific line cultivars. System cultivar interactions were generally very low and highly dependent on environmental conditions. We conclude that while cultivar breeding for mixtures can be successful in monocultures, high environmental variation highlights the necessity of evaluating cultivars in mixtures. In addition, use of intraspecific diversity within interspecific mixed cropping systems can be a valuable addition to further improve mixture performance and its stability under increasing environmental stresses due to climate change.
Genetic Analysis of Platform-Phenotyped Root System Architecture of Bread and Durum Wheat in Relation to Agronomic Traits
Authors: Colombo Michel , Roumet Pierre , Salon Christophe , Jeudy Christian , Lamboeuf Mickael , Lafarge Stéphane , Dumas Anne-Valérie , Dubreuil Pierre , Ngo Wa , Derepas Brice , Beauchêne Katia , Allard Vincent , Le Gouis Jacques , Rincent Renaud
Published: March 2022

Roots are essential for water and nutrient uptake but are rarely the direct target of breeding efforts. To characterize the genetic variability of wheat root architecture, the root and shoot traits of 200 durum and 715 bread wheat varieties were measured at a young stage on a high-throughput phenotyping platform. Heritability of platform traits ranged from 0.40 for root biomass in durum wheat to 0.82 for the number of tillers. Field phenotyping data for yield components and SNP genotyping were already available for all the genotypes. Taking differences in earliness into account, several significant correlations between root traits and field agronomic performances were found, suggesting that plants investing more resources in roots in some stressed environments favored water and nutrient uptake, with improved wheat yield. We identified 100 quantitative trait locus (QTLs) of root traits in the bread wheat panels and 34 in the durum wheat panel. Most colocalized with QTLs of traits measured in field conditions, including yield components and earliness for bread wheat, but only in a few environments. Stress and climatic indicators explained the differential effect of some platform QTLs on yield, which was positive, null, or negative depending on the environmental conditions. Modern breeding has led to deeper rooting but fewer seminal roots in bread wheat. The number of tillers has been increased in bread wheat, but decreased in durum wheat, and while the root-shoot ratio for bread wheat has remained stable, for durum wheat it has been increased. Breeding for root traits or designing ideotypes might help to maintain current yield while adapting to specific drought scenarios.
Brassinosteroids Positively Regulate Plant Immunity via BRI1-EMS-SUPPRESSOR 1-Mediated GLUCAN SYNTHASE-LIKE 8 Transcription
Authors: Xiong Jiawei , Wan Xiaoping , Ran Maolin , Xu Xiumei , Chen Lezhang , Yang Feng
Published: March 2022

Plant hormone brassinosteroids (BRs) play key roles in plant adaptation to biotic stresses, including various pathogen infections. As a core factor in BR signaling, the transcription factor BRI1-EMS-SUPPRESSOR 1 (BES1) activates BR responses via regulating the expression of target genes. However, the molecular mechanism of BRs in regulating plant immunity is unclear, and the key components are not identified. In this study, we found that BR biosynthesis and signaling transduction are essential for plant resistance to pathogen infection, and BR biosynthesis or BR signaling-deficient mutants displayed susceptibility to Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) infection [including more serious symptoms and more photosystem II (PSII) photochemistry damage]. We identified a callose synthase gene GLUCAN SYNTHASE-LIKE 8 (GSL8) as a direct target of BES1, and its expression was induced by BRs/BES1. Meanwhile, BRs induced callose accumulation after Pst DC3000 infection. Moreover, BES1 gain-of-function mutant bes1-D showed promoted Pst DC3000 resistance. GSL8 T-DNA insertion mutant gsl8-1 was susceptible to DC3000, while brassinolide (BL) treatment partially rescued gsl8-1 susceptible phenotypes. Our study suggests that BR-induced pathogen resistance partly depends on the BR-induced BES1-GSL8 cascade to mediate callose accumulation.
A Proteome-Level Investigation Into Plasmodiophora brassicae Resistance in Brassica napus Canola
Authors: Adhikary Dinesh , Mehta Devang , Uhrig R. Glen , Rahman Habibur , Kav Nat N. V.
Published: March 2022

Clubroot of Brassicaceae, an economically important soil borne disease, is caused by Plasmodiophora brassicae Woronin, an obligate, biotrophic protist. This disease poses a serious threat to canola and related crops in Canada and around the globe causing significant losses. The pathogen is continuously evolving and new pathotypes are emerging, which necessitates the development of novel resistant canola cultivars to manage the disease. Proteins play a crucial role in many biological functions and the identification of differentially abundant proteins (DAP) using proteomics is a suitable approach to understand plant–pathogen interactions to assist in the development of gene specific markers for developing clubroot resistant (CR) cultivars. In this study, P. brassicae pathotype 3 (P3H) was used to challenge CR and clubroot susceptible (CS) canola lines. Root samples were collected at three distinct stages of pathogenesis, 7−, 14−, and 21-days post inoculation (DPI), protein samples were isolated, digested with trypsin and subjected to liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis. A total of 937 proteins demonstrated a significant (q-value < 0.05) change in abundance in at least in one of the time points when compared between control and inoculated CR-parent, CR-progeny, CS-parent, CS-progeny and 784 proteins were significantly (q < 0.05) changed in abundance in at least in one of the time points when compared between the inoculated- CR and CS root proteomes of parent and progeny across the three time points tested. Functional annotation of differentially abundant proteins (DAPs) revealed several proteins related to calcium dependent signaling pathways. In addition, proteins related to reactive oxygen species (ROS) biochemistry, dehydrins, lignin, thaumatin, and phytohormones were identified. Among the DAPs, 73 putative proteins orthologous to CR proteins and quantitative trait loci (QTL) associated with eight CR loci in different chromosomes including chromosomes A3 and A8 were identified. Proteins including BnaA02T0335400WE, BnaA03T0374600WE, BnaA03T0262200WE, and BnaA03T0464700WE are orthologous to identified CR loci with possible roles in mediating clubroot responses. In conclusion, these results have contributed to an improved understanding of the mechanisms involved in mediating response to P. brassicae in canola at the protein level.
Landscape Genomics Provides Evidence of Ecotypic Adaptation and a Barrier to Gene Flow at Treeline for the Arctic Foundation Species Eriophorum vaginatum
Authors: Stunz Elizabeth , Fetcher Ned , Lavretsky Philip , Mohl Jonathon E. , Tang Jianwu , Moody Michael L.
Published: March 2022

Global climate change has resulted in geographic range shifts of flora and fauna at a global scale. Extreme environments, like the Arctic, are seeing some of the most pronounced changes. This region covers 14% of the Earth’s land area, and while many arctic species are widespread, understanding ecotypic variation at the genomic level will be important for elucidating how range shifts will affect ecological processes. Tussock cottongrass (Eriophorum vaginatum L.) is a foundation species of the moist acidic tundra, whose potential decline due to competition from shrubs may affect ecosystem stability in the Arctic. We used double-digest Restriction Site-Associated DNA sequencing to identify genomic variation in 273 individuals of E. vaginatum from 17 sites along a latitudinal gradient in north central Alaska. These sites have been part of 30 + years of ecological research and are inclusive of a region that was part of the Beringian refugium. The data analyses included genomic population structure, demographic models, and genotype by environment association. Genome-wide SNP investigation revealed environmentally associated variation and population structure across the sampled range of E. vaginatum, including a genetic break between populations north and south of treeline. This structure is likely the result of subrefugial isolation, contemporary isolation by resistance, and adaptation. Forty-five candidate loci were identified with genotype-environment association (GEA) analyses, with most identified genes related to abiotic stress. Our results support a hypothesis of limited gene flow based on spatial and environmental factors for E. vaginatum, which in combination with life history traits could limit range expansion of southern ecotypes northward as the tundra warms. This has implications for lower competitive attributes of northern plants of this foundation species likely resulting in changes in ecosystem productivity.
Phytohormonal Regulation Through Protein S-Nitrosylation Under Stress
Authors: Pande Anjali , Mun Bong Gyu , Rahim Waqas , Khan Murtaza , Lee Da Sol , Lee Geun Mo , Al Azzawi Tiba Nazar Ibrahim , Hussain Adil , Kim Chang Kil , Yun Byung Wook
Published: March 2022

The liaison between Nitric oxide (NO) and phytohormones regulates a myriad of physiological processes at the cellular level. The interaction between NO and phytohormones is mainly influenced by NO-mediated post-translational modifications (PTMs) under basal as well as induced conditions. Protein S-nitrosylation is the most prominent and widely studied PTM among others. It is the selective but reversible redox-based covalent addition of a NO moiety to the sulfhydryl group of cysteine (Cys) molecule(s) on a target protein to form S-nitrosothiols. This process may involve either direct S-nitrosylation or indirect S-nitrosylation followed by transfer of NO group from one thiol to another (transnitrosylation). During S-nitrosylation, NO can directly target Cys residue (s) of key genes involved in hormone signaling thereby regulating their function. The phytohormones regulated by NO in this manner includes abscisic acid, auxin, gibberellic acid, cytokinin, ethylene, salicylic acid, jasmonic acid, brassinosteroid, and strigolactone during various metabolic and physiological conditions and environmental stress responses. S-nitrosylation of key proteins involved in the phytohormonal network occurs during their synthesis, degradation, or signaling roles depending upon the response required to maintain cellular homeostasis. This review presents the interaction between NO and phytohormones and the role of the canonical NO-mediated post-translational modification particularly, S-nitrosylation of key proteins involved in the phytohormonal networks under biotic and abiotic stresses.
COVID-19 Induced Misinformation on YouTube: An Analysis of User Commentary
Authors: Suter Viktor , Shahrezaye Morteza , Meckel Miriam
Published: March 2022

Several scholars have demonstrated a positive link between political polarization and the resistance to COVID-19 prevention measures. At the same time, political polarization has also been associated with the spread of misinformation. This study investigates the theoretical linkages between polarization and misinformation and measures the flow of misinformation about COVID-19 in the comment sections of four popular YouTube channels for over 16 months using big data sources and methods. For the analysis, we downloaded about 3.5M English language YouTube comments posted in response to videos about the pandemic. We then classified the comments into one of the two following categories by applying a supervised Natural Language Processing classifier: (1)fake: comments that contain claims and speculation which are verifiably not true; and (2)legitimate:comments that do not fall into the fake category. The results show that the level of misinformation in YouTube comment sections has increased during the pandemic, that fake comments attract statistically more likes, and that the ratio of fake comments increased by 0.4% per month. These findings suggest that once introduced into an online discussion, misinformation potentially leads to an escalating spiral of misinformation comments, which undermines public policy. Overall, the results signal alarming pandemic-related misinformation and, potentially, rising levels of affective polarization. We place these results in context and point out the limitations of our approach.
Paternalistic Leadership and Job Embeddedness With Relation to Innovative Work Behaviors and Employee Job Performance: The Moderating Effect of Environmental Dynamism
Authors: Yamin Mohammad Ali
Published: March 2022

The current study strives to examine the determinants of employee innovative work behavior and job performance. Therefore, an integrated research model is developed with the help of paternalistic leadership style and job embeddedness theory to investigate employee behavior toward innovative work behavior. The research model is extended with the moderating effect of environmental dynamism between the relationship of innovative work behavior and employee job performance. Data were collected from 411 employees working in small medium enterprises. For inferential analysis, the structural equation modeling (SEM) technique is used. Results of the structural equation modeling revealed that altogether paternalistic leadership style and factors underpinning job embeddedness theory have explained 52.1% of the variance in employee innovate work behavior. The findings of this research suggest that managers and policy makers should focus on benevolent leadership, moral leadership, and on-the-job embeddedness to boost employee job performance and innovative work behavior.
Different Neural Information Flows Affected by Activity Patterns for Action and Verb Generation
Authors: Wang Zijian , Zhang Zuo , Sun Yaoru
Published: March 2022

Shared brain regions have been found for processing action and language, including the left inferior frontal gyrus (IFG), the premotor cortex (PMC), and the inferior parietal lobule (IPL). However, in the context of action and language generation that shares the same action semantics, it is unclear whether the activity patterns within the overlapping brain regions would be the same. The changes in effective connectivity affected by these activity patterns are also unclear. In this fMRI study, participants were asked to perform hand action and verb generation tasks toward object pictures. We identified shared and specific brain regions for the two tasks in the left PMC, IFG, and IPL. The mean activation level and multi-voxel pattern analysis revealed that the activity patterns in the shared sub-regions were distinct for the two tasks. The dynamic causal modeling results demonstrated that the information flows for the two tasks were different across the shared sub-regions. These results provided the first neuroimaging evidence that the action and verb generation were task context driven in the shared regions, and the distinct patterns of neural information flow across the PMC-IFG-IPL neural network were affected by the polymodal processing in the shared regions.
Idiopathic Sudden Sensorineural Hearing Loss in Different Ages: Prognosis of Patients With Initial Total Hearing Loss
Authors: Xiong Wenping , Dai Qinglei , Wang Yingjun , Hou Zhiqiang , Lu Kunpeng , Sun Xiao , Duan Fujia , Wang Haibo , Zhang Daogong , Wang Mingming
Published: March 2022

Objective

This study aimed to analyze the hearing improvement and prognosis factors of idiopathic sudden sensorineural hearing loss (ISSNHL) in different ages with initial total hearing loss.

Methods

We reviewed the medical records of 5,711 hospitalized patients with ISSNHL from 2016 to 2021 in our center. All of the patients had been treated with uniform combination drug therapy. After excluding the patients with initial partial hearing loss and those diagnosed with clear etiology, 188 patients were enrolled in this study and divided into six age groups (18–30, 31–40, 41–50, 51–60, 61–70, ≥ 71 years). In all groups, decreases in pure-tone average (PTA) 1 month posttreatment, effective rate, and clinical characteristics (vertigo, tinnitus, hospital stay, comorbidity, and inner ear magnetic resonance imaging) were analyzed.

Results

Among the 188 enrolled patients, 86% had vertigo. Complete recovery was seen in 0.5% of patients, and marked recovery was seen in 43% of patients. The mean 1 month posttreatment PTAs were as follows: 18–30 years: 80 ± 7.5 dB; 31–40 years: 100 ± 9.0 dB; 41–50 years: 99 ± 8.3 dB; 51–60 years: 101 ± 8.6 dB; 61–70 years: 96 ± 9.6 dB; and ≥ 71 years: 88 ± 13.0 dB. Compared with the other groups, the 18–30- years group showed better recovery of hearing threshold in five frequencies (0.25, 0.5, 1, 2, and 4 kHz, respectively, at octave or semioctave frequencies under air conduction), and the recovery of hearing threshold at 0.25 and 0.5 Hz was better than the recovery at 1, 2, and 4 kHz. According to the results of the chi-square test statistical analysis, vertigo and comorbidities were associated with a poor prognosis of ISSNHL.

Conclusion

In summary, the treatment outcomes of patients with ISSNHL with initial total hearing loss were poor. There was a significant age-related difference with respect to marked recovery 1 month posttreatment, and the 18–30- years group showed better recovery than the other age groups.
Relationship Between Hardiness and the Mental Health of Funded Chinese College Students: The Mediating Role of Social Support and the Moderating Role of an Only-Child Status
Authors: Liu Jingxuan , Cheng Xiaoshuang , Li Jun
Published: March 2022

According to the hardiness model and the perspective of different treatment by parents, this study developed and validated a moderated mediation model to explore the direct effect of hardiness on the mental health of Chinese funded college students (FCSs), the mediating role of social support, and the moderating role of only-child (OC) /non-only-child (NOC) status. A hardiness scale, mental health scale, and perceived social support scale were used to examine information on 673 Chinese FCSs. Hardiness had a significantly positive effect on the mental health of FCSs. Mediation analysis indicated that social support mediated the relationship between hardiness and the mental health of FCSs. The moderated mediation model analysis indicated that the OC/NOC status moderated the second half of the mediation model. The results suggest that the hardiness model is applicable to FCSs from China and elucidate the internal influence mechanism between hardiness and mental health. On the basis of the findings of this study, suggestions are presented in this paper for college education management.
A Single Belief-Changing Psychedelic Experience Is Associated With Increased Attribution of Consciousness to Living and Non-living Entities
Authors: Nayak Sandeep M. , Griffiths Roland R.
Published: March 2022

Introduction

Although the topic of consciousness is both mysterious and controversial, psychedelic drugs are popularly believed to provide unique insights into the nature of consciousness despite a lack of empirical evidence.

Methods

This study addresses the question of whether psychedelics change the attribution of consciousness to a range of living and non-living entities. A survey was conducted in 1,606 respondents who endorsed a belief changing psychedelic experience.

Results

Participants rated their attributions of consciousness to a range of living and non-living entities before and after their psychedelic experience. Superstitious beliefs and belief in freewill were also assessed. From before the experience to after, there were large increases in attribution of consciousness to various entities including non-human primates (63–83%), quadrupeds (59–79%), insects (33–57%), fungi (21–56%), plants (26–61%), inanimate natural objects (8–26%), and inanimate manmade objects (3–15%). Higher ratings of mystical experience were associated with greater increases in the attribution of consciousness. Moreover, the increased attributions of consciousness did not decrease in those who completed the survey years after the psychedelic experience. In contrast to attributions of consciousness, beliefs in freewill and superstitions did not change. Notably, all findings were similar when restricted to individuals reporting on their first psychedelic experience.

Discussion

This study demonstrates that, among people who reported belief-changing psychedelic experiences, attribution of consciousness to various entities increases. Future prospective psychedelic drug administration studies that control for expectancies are needed.
Social Identity Complexity, Corporate Social Responsibility, and Brand Love of Multiple Leagues in Professional Sport
Authors: Do Chanwook , Brison Natasha T. , Park Juho , Lee Hyun-Woo
Published: March 2022

How can corporate social responsibility initiatives influence brand love? Based on the theory of social identity complexity, we examined whether greater complexity of a sport fan’s multiple identifications with sport leagues led to higher multicultural tolerance and more positive perceptions of leagues’ corporate social responsibility activities. Further, brand authenticity was tested as a variable intervening between perceived corporate social responsibility and brand love. We analyzed this serial mediation effect impacting sport fans’ brand love for their multiple, favored and less favored, sport leagues. Participants (N = 242 Amazon Mechanical Turk workers) answered the scale item questionnaire for model assessment. The hypothesized model was supported as the indirect effect through all mediators was significant (43.42% of total indirect effects). Our results suggest that when sport fans acknowledge a high overlap among league fan groups (low social identity complexity), their tolerance is more likely to be higher than those who have a low overlap. Such high levels of tolerance influence how fans perceive corporate social responsibility initiatives, and these effects build up for fans to perceive the brand to be more authentic (i.e., based on their continuity, credibility, integrity, and symbolism). These antecedents affected brand love through a serial mediation. Sport league managers should consider the diverse aspects across leagues (i.e., different fan characteristics, media operations, game schedules) for harmonious coexistence with other leagues (e.g., by collaborating on promotions and reducing overlap of schedules) and maintain brand authenticity for their social initiatives to result in a greater brand love in the consumer’s mind.
Personal Competition Among Sports Players and Their Performance as a Team: A Moderated Mediation Model
Authors: Li Jinling
Published: March 2022

Personal competition among colleagues and co-workers has been observed in order to prove their professional superiority over others. Such behaviors have grave consequences on the overall team performance. The aim of this study was to investigate the role of personal competition on team performance incorporating the mediating role of the playing dumb behavior of knowledge hiding. The study has further checked the moderating effect of task interdependence on the relationship between personal competition and playing dumb. Data for the present study had been collected through questionnaires from the sports players actively associated with games through their educational institutes in China. The sample size of the study was 339, selected on the basis of convenience sampling. Smart PLS had been employed to analyze the data through structural equation modeling (SEM). The results of the study showed a strong impact of personal competition on team performance and the playing dumb variable. Furthermore, playing dumb has been found to have a strong mediating impact on team performance. The study has theoretically contributed to the literature of competition and performance by investigating the mediating role of playing dumb. The study also offers certain practical implications to the managers of the corporate world to devise such human resource policies that take appraisals from the colleagues so as to rectify the negative workplace behaviors and could be worked out accordingly.
Maternal Suicide Ideation and Behaviour During Pregnancy and the First Postpartum Year: A Systematic Review of Psychological and Psychosocial Risk Factors
Authors: Reid Holly E. , Pratt Daniel , Edge Dawn , Wittkowski Anja
Published: March 2022

Suicide is a leading cause of maternal death during pregnancy and up to a year after birth (perinatal period). Many psychological and psychosocial risk factors for maternal suicidal ideation and behaviour have been investigated. Despite this, there have been no attempts to systematically search the literature on these risk factors. Additionally, few studies have described how the risk factors for suicidal ideation, attempted suicides and suicide deaths differ, which is essential for the development of tools to detect and target suicidal ideation and behaviour. Seven databases were searched up to June 2021 for studies that investigated the association between suicidal ideation and/or suicidal behaviour and psychological/psychosocial risk factors in pregnant and postpartum women. The search identified 17,338 records, of which 59 were included. These 59 studies sampled a total of 49,929 participants and investigated 32 different risk factors. Associations between abuse, experienced recently or during childhood, and maternal suicide ideation, attempted suicide and death were consistently reported. Social support was found to be less associated with suicide ideation but more so with suicide attempts. Identifying women who have experienced domestic violence or childhood abuse and ensuring all women have adequate emotional and practical support during the perinatal period may help to reduce the likelihood of suicidal behaviour.
Quality of Life, Sexual Health, and Associated Factors Among the Sexually Active Adults in a Metro City of India: An Inquiry During the COVID-19 Pandemic-Related Lockdown
Authors: Chatterjee Seshadri Sekhar , Bhattacharyya Ranjan , Chakraborty Amrita , Lahiri Arista , Dasgupta Abhijit
Published: March 2022

Background

Sexual dysfunction (SD) and its effect on our life is an important but less studied topic especially during post-COVID era. This study examines the extent of SD and other mental health predictors and their effect on quality of life.

Methods

A cross-sectional survey of sexually active adults was conducted in an Indian metro-city. Along with sociodemographic data, sexual dysfunction, depression, anxiety, stress, and quality of life were assessed by Arizona Sexual Experience Scale (ASEX), Depression Anxiety and Stress Scale (DASS), and WHOQOL-BREF, respectively. Structural equations modeling was used to understand their relationship.

Results

Out of the total 1,376 respondents, 80.52% were male, 65.98% were married, and 48.54% were graduates. The mean age of the participants was 34.42 (±9.34) years. Of the participants, 27.18% had sexual dysfunction. Majority of the respondents did not have depression (59.30%), anxiety (52.33%), or stress (44.48%). Mild and moderate levels were the commonest findings among those who had depression, anxiety, or stress. Among the respondents, 27.18% had sexual dysfunction as per the ASEX instrument. Increase in age and female gender were associated with sexual dysfunction overall and also all its components. Presence of depression adversely affected ease of achieving orgasm and satisfaction from orgasm and was associated with sexual dysfunction overall. The respondents had a mean score of 73.57 (±13.50) as per the WHO-QOL. Depression and stress emerged as statistically significant factors for poor quality of life, while sexual dysfunction was not associated statistically.

Conclusion

More than one-fourth of the study population reported sexual dysfunction during the first wave of the pandemic in India. The study findings highlight the role of poor mental health issues in this regard. In fact, issues like depression and stress were associated with poor quality of life as well. The current findings unequivocally warrant specific interventions to improve mental health of the respondents.
Prevalence and Associated Factors of Common Mental Disorders Among Pregnant Mothers in Rural Eastern Ethiopia
Authors: Tamiru Dawit , Misgana Tadesse , Tariku Mandaras , Tesfaye Dejene , Alemu Daniel , Weldesenbet Adisu Birhanu , Gebremichael Berhe , Dheresa Merga
Published: March 2022

Background

Antenatal common mental disorder is a significant public health issue, especially in low- and middle-income countries with an extensive treatment gap. Common mental disorders have multifaceted implications on maternal and fetal health outcomes during pregnancy with long-running economic and social sequels. This study aimed to determine the prevalence of common mental disorder and associated factors among pregnant mothers in eastern Ethiopia, Kersa and Haramaya Health, and Demographic surveillance sites.

Methods

A community-based cross-sectional study was conducted in Kersa and Haramaya health and demographic surveillance sites from January 30 to April 30, 2021. World Health Organization Self-Reporting Questionnaire (SRQ-20) was used to measure common mental disorder among 1,015 randomly selected pregnant women. Data were collected face-to-face using open data kit software. Logistic regression was fitted to identify factors associated with common mental disorders.

Results

The overall prevalence of common mental disorders (SRQ > 6) among pregnant women was 37.5% (95% CI: 34.5, 40.5). Current substance use (AOR = 1.99, 95% CI 1.37, 2.88), intimate partner violence (AOR = 2.67, 95% CI 2.02, 3.53), null parity (AOR = 3.10, 95% CI 1.65, 5.84), gestational age [first trimester (AOR = 2.22, 95% CI 1.01, 4.93) and third trimester (AOR = 1.74, 95% CI 1.31, 2.31)], history of abortion (AOR = 2.03, 95% CI 1.27, 3.24), and absence of antenatal care follow-up (AOR = 1.43, 95% CI 1.08, 1.89) were significantly associated with common mental disorder during pregnancy.

Conclusion

Common mental disorders are prevalent among pregnant women in the study area with significant correlates. Administration of regular screening programs for maternal mental health conditions in rural, low-income communities, integrating into primary health care settings is imperative to reduce the risk.
Empathy, Theory of Mind, and Prosocial Behaviors in Autistic Children
Authors: Wang Xin , Auyeung Bonnie , Pan Ning , Lin Li-Zi , Chen Qian , Chen Jia-Jie , Liu Si-Yu , Dai Mei-Xia , Gong Jian-Hua , Li Xiu-Hong , Jing Jin
Published: March 2022

Background:

Previous research has suggested that children with autism spectrum disorder (ASD) display fewer prosocial behaviors, and the role of empathy or Theory of Mind (ToM) in prosocial behaviors of autistic children remains unclear.

Methods

Data were obtained from an ongoing longitudinal study in Guangzhou, China. A total of 96 autistic children and 167 typically developing (TD) children were enrolled. Prosocial behaviors were assessed using a subscale of the Strength and Difficulties Questionnaire and Dictator Game (DG) paradigm with stickers as incentives. Empathic traits and ToM ability were measured using the children's Empathy Quotient and the Chinese version of ToM toolkit. Generalized linear models were used to assess the differences of prosocial behaviors and empathic traits, ToM ability between the two groups and the associations between empathic traits, ToM ability and prosocial behaviors in autistic children.

Results

Compared with TD children, autistic children exhibited worse ToM ability and performed less pro-socially in the DG paradigm, while there were no differences regarding empathic traits. In autistic children, empathic traits especially affective empathy, were positively associated with parent-reported prosocial behaviors [β = 0.17, 95% confidence interval (CI): 0.07–0.27; β = 0.47, 95%CI: 0.33–0.60]. ToM ability was associated with DG paradigm (β = 1.03, 95%CI: 0.16–1.89).

Conclusion

Autistic children showed less pro-sociality and ToM ability than TD children. In autistic children, empathic trait was associated with parent-reported prosocial behaviors while their ToM ability was associated with prosocial behaviors in experimental condition. Our findings indicated that better ToM ability and empathic trait might promote prosocial behaviors in autistic children.
Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors
Authors: Kurzina Natalia , Belskaya Anastasia , Gromova Arina , Ignashchenkova Alla , Gainetdinov Raul R. , Volnova Anna
Published: March 2022

Attention deficit hyperactivity disorder (ADHD) is manifested by a specific set of behavioral deficits such as hyperactivity, impulsivity, and inattention. The dopamine neurotransmitter system is postulated to be involved in the pathogenesis of ADHD. Guanfacine, a selective α2A-adrenoceptor agonist, is prescribed for ADHD treatment. ADHD also is known to be associated with impairment of multiple aspects of cognition, including spatial memory, however, it remains unclear how modulation of the norepinephrine system can affect these deficits. Hyperdopaminergic dopamine transporter knockout (DAT-KO) rats are a valuable model for investigating ADHD. The DAT-KO rats are hyperactive and deficient in spatial working memory. This work aimed to evaluate the effects of noradrenergic drugs on the fulfillment of spatial cognitive tasks by DAT-KO rats. The rats were tested in the Hebb – Williams maze during training and following noradrenergic drugs administration. The efficiency of spatial orientation was assessed as to how fast the animal finds an optimal way to the goal box. Testing in a new maze configuration allowed us to evaluate the effects of drug administration after the acquisition of the task rules. The behavioral variables such as the distance traveled, the time to reach the goal box, and the time spent in the error zones were analyzed. It has been observed that α2A-adrenoceptor agonist Guanfacine (0.25 mg/kg) had only a minimal inhibitory effect on hyperactivity of DAT-KO rats in the maze but significantly ameliorated their perseverative pattern of activity and reduced the time spent in the error zones. In contrast, α2A-adrenoceptor antagonist Yohimbine, at the dose of 1 mg/kg, increased the distance traveled by DAT-KO rats and elevated the number of perseverative reactions and the time spent in the error zones. Guanfacine caused minimal effects in wild-type rats, while Yohimbine altered several parameters reflecting a detrimental effect on the performance in the maze. These data indicate that modulation of α2A-adrenoceptor activity potently affects both dopamine-dependent hyperactivity and cognitive dysfunctions. Similar mechanisms may be involved in the beneficial effects of Guanfacine on cognitive deficits in ADHD patients. This study further supports the translational potential of DAT-KO rats for testing new pharmacological drugs.