bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Digitalization on Entrepreneurship Development in the Context of Business Innovation Management
Authors: Rahim Sadigov Rahim Sadigov
Published: May 2022

The article discusses current digitalization trends from the perspective of business innovation management, the relevance of which has increased significantly during the COVID-19 pandemic. The relationship between the innovative and digital profile indicators and the level of entrepreneurship development is analysed and substantiated based on the world and European experience in general and Azerbaijan in particular. The study's main goal is empirical confirmation, formalization, and evaluation of digitalization's impact on entrepreneurship development in Azerbaijan, some European and Asian countries to improve public policy in the areas under study. For achieving the study goals, scientific methods of statistical, analytical, graphical, correlation and regression analysis, and economic and mathematical modelling using Excel and Stata software products were applied. The information base of the study is formed from scientific papers and publications in the field of innovation management, digital economy, and entrepreneurship, as well as World Bank data for a sample of 14 countries in Europe and Asia (Azerbaijan, Czech Republic, Estonia, Georgia, Hungary, Kazakhstan, the Kyrgyz Republic, Latvia, Lithuania, Poland, Romania, Slovenia, Slovak Republic, and Ukraine) for 2006-2020. The author characterized trends in the total number of new firms, the overall density of business and the density of new business in the countries included in the sample, and indicators of the relative cost of procedures and the time to start a business in the studied countries. Particular attention is paid to the export and import of ICT goods, communication and computer services. A panel data regression model with fixed effects has been built to determine the influence of digitalization parameters on the business sector's development parameters. Evaluating the impact of digitalization on entrepreneurship development in Azerbaijan and other European and Asian countries could be useful to scientists, researchers, public authorities and local governments, business structures, and entrepreneurs.
The Relationship between Metaphorical Perceptions of Consumption and Mental Well-Being in the Period of COVID-19
Authors: Zengin Hayrettin
Published: May 2022

This study aims to examine the relationship between the interpretation of the consumption concept of individuals and their mental well-being levels during the pandemic period. Metaphors are the essential communication tools used in defining and interpreting the consumption concept. The effort to reveal the interpretations loaded on a complex and multidimensional concept such as individuals' consumption expresses the important contribution of this research. The fact that these interpretations were made during the pandemic turned individuals' lives upside-down increases the degree of contribution. The study's originality has been tried to be revealed by establishing a relationship between the interpretations of the consumption phenomenon of individuals and their mental well-being. The Conceptual Metaphor Theory developed by Lakoff and Johnson was used in metaphorical interpretation. The metaphorical approach, which is one of the alternative approaches based on subjective experiences, enables the comprehension of concrete and well-known concepts, abstract concepts, symbols, or elements that are more difficult and complex to understand. The Warwick-Edinburgh Mental Well-being Scale (WEMWBS) was used to determine the mental well-being levels of individuals. All the metaphors developed and evaluated regarding the concept of consumption have been grouped into three conceptual categories: «pleasure, insatiability and vanity», «necessity and requirement», and «addictive and harmful». In this study, the mental well-being average of all participants was calculated as 53.46. The lowest average was calculated in the «addictive and harmful» category according to conceptual categories in terms of mental well-being averages. It was determined that the mental well-being averages of the participants who interpreted the concept of consumption as «negative» were also low.
The Analysis of R&D Impact on the Public Listed Companies’ Performance in Indonesia
Authors: E. Natasha I. , Hutagaol Yanthi R. I.
Published: May 2022

Research & Development (R&D) is one of significant firms’ activities that is expected to enhance firms’ future value. This paper examines the relationship between R&D with firm’s operation and market performance. The sample used is 106 firm years from 32 non-finance firms that listed in Indonesia Stock Exchange (IDX) and report R&D expenditure during period 2004-2007. Two research hypotheses are developed and tested using a multiple regression model. The findings signify that all sample firms have reported their R&D activities accordingly to the applied accounting standard. However, the hypothesis testing results shows that there is no relationship between R&D and firm’s operation and market performance. These findings imply that R&D activities in Indonesian firms are not yet perceived as an important element in firms’ value added chain.
Analisis Pengaruh Rasio ROA, LDR, NIM dan NPL Terhadap Abnormal Return Saham Perbankan di Indonesia pada Periode Sekitar Pengumuman Subprime Mortgage
Authors: Syauta Risky Christian , Widjaja Indra
Published: May 2022

Information has strongly influenced the capital market condition. The information could come from internal company as well as external parties. If an event contains information, usually the market will react at the time information is revealed to the market. An event study method could be used to test the content of information from the event. Like other market, Bursa Efek Indonesia is related to some information. This research analyzes the USA mortgage sub-prime effect on the banking stocks in Indonesia. The reaction from market could be seen in return abnormal changes in 7 days before and after the announcement. A sample of 26 banking stocks is chosen for this research to test the effect of USA sub-prime mortgage on banking stocks in Indonesia, particularly on its Return On Assets (ROA), Loan to Deposit Ratio (LDR), Net Interest Margin (NIM) and Non Performing Loan (NPL) with t-test and multiple regression. The result shows the abnormal returns of banking stocks at BEI are significantly influenced by USA sub-prime mortgage except 5 days and 1 day before the announcement and 1 day and 6 days after. The banking performances, ROA and NPL, are also affected by the USA sub-prime mortgage.
Pengaruh Pemilihan Metode Akuntansi Atas Biaya Research and Development (R&D) Terhadap Price Earnings Ratio (Studi Empirik Pada Perusahaan Sektor Industri Periode 2002-2005)
Authors: Suharli Michell , Arisandi Ani
Published: May 2022

Earnings reflect the equity growth stemmed from various economic transaction, except shareholders’ transactions in certain periods. Similar to the net income concept, earnings concept includes all transactions in net revenue in current period. The research sample is 14 listed companies that reported Research & Development (R&D) expenses during 2002-2004 period. Research variables used are earnings (as the dependent variable) that is proxied by price earning ratio (PER), and accounting method chosen to record the R&D expenses (as the independent variable). The research model is a simple regression model. The result shows that accounting method chosen is significantly related to the PER, however appears does not influence the profit of the company.
FACTORS AFFECTING FRAUD PREVENTION AND ITS IMPLICATION TO THE QUALITY OF FINANCIAL STATEMENTS
Authors: Budiman Monika , Anwar Choirul , Sudjono Sudjono
Published: May 2022

The study aims to determine the effect of internal control, internal audit, risk-based audit, audit committee, and whistleblowing system on fraud prevention and its implications to the quality of financial statements. The sample consisted of 7 companies from 12 populations of chemical sub-sector companies and 5 companies from 10 populations of pharmaceutical sub-sector companies listed on the Indonesia Stock Exchange in 2018. Data were collected using questionnaires with 154 respondents. The analysis technique using Structural Equation Modeling (SEM) and processed with Lisrel 8.8. The results indicate that, partially, internal control, internal audit, risk-based audit, and audit committee have a positive and significant effect on fraud prevention, while the whistleblowing system partially has a negative and insignificant effect. However, simultaneously, the direct effect of internal control, internal audit, risk-based audit, audit committee, and whistleblowing system on fraud prevention have a positive and significant effect. The results also show partially internal control, internal audit, whistleblowing system, and fraud prevention have a positive and significant effect on the quality of financial statements while risk-based audit has a positive but not significant effect and the audit committee has a negative and insignificant effect on the quality of financial statements. However, simultaneously, the indirect effect of internal control, internal audit, risk-based audit, audit committee, whistleblowing system on the quality of financial statements through fraud prevention have a positive and significant effect.
APPLIED PUBLIC SECTOR ACCOUNTING FOR BROADBAND INFRASTRUCTURE DEVELOPMENT WITH PUBLIC PRIVATE PARTNERSHIP SCHEME: A LITERATURE REVIEW
Authors: Steelyana Evi
Published: May 2022

Governments all around the world are increasingly focusing on Public-Private-Partnership (PPP) schemes to develop broadband infrastructure. Private sector participation in the development and funding of public infrastructure has had a substantial impact on the delivery of public services. In PPP Broadband Infrastructure, there has been no attempt to integrate the literatures in order to present a holistic view. To expand our knowledge of PPPs in Public Sector Accounting Discipline, the author conducted a systematic literature review of articles published in international journals and to analyze the contribution of it to the body of knowledge. By using a qualitative method, the objective of the study is to find the major theme of public sector accounting literatures based on research of PPP in Broadband Infrastructure for the past 20 years (2000-2020)  from the qualified international journals. The study also aims to find contribution of the major theme on infrastructure development and the direction of  the future research that  need to be addressed.  The study found that UK is the country which has been publishing journals on PPP with high intensity of publication. Another findings are the literatures were published in high quality journal with scopus indexed  is 60% in Q1 and followed 25% in Q2 and 15% in Q3. The main findings of this study identified four main topics in this discipline which are Public Policy Strategy has become the major theme in the field of research and become the first rank, followed by another themes which are PPP Implementation, PPP Framework and Value of Money.  Therefore, in PPP research as part of Public Sector Accounting Literatures has shown that Public Policy Strategy as part of government’s role in shaping the regulatory framework and plays an important role to catalyst the infrastructure development into the next level.
CORPORATE GOVERNANCE AND EARNINGS MANAGEMENT: EVIDENCE OF LISTED INDONESIAN COMPANIES
Authors: Natasya Evelyn
Published: May 2022

The purpose of this research is to investigate the relationship of corporate governance  such as competence of board commissioner and audit committee, audit quality and earnings management in 434 manufacturing sector companies listed in Indonesia Stock Exchange period year 2016-2018. Earnings management proxied by discretionary accrual and profitability proxied by return-on-asset. The results of this study are: (1) firm’s size as control variable is significantly negative influences earnings management (2) profitability which proxied by return-on-asset is significantly negative influences earnings management. Meanwhile, this research did not find support evidence that competence of board commissioner, competence of audit committee, audit quality, revenue growth connection significantly influences on earnings management. Companies can analyze the earnings management through company size and financial ratios such as profitability.
THE COMPARATIVE ANALYSIS OF FINANCIAL PERFORMANCE AND TRADING VOLUME DURING MERS AND COVID-19 ON THE INDONESIA AND MALAYSIA STOCK EXCHANGE
Authors: Hamid Agustini , Arshanty Risky
Published: May 2022

We investigate the differences of financial performance and stock trading volume during the MERS and COVID-19 periods on the Indonesia and Malaysia Stock Exchanges. We used Wilcoxon Signed Rank Test. Wilcoxon Signed Rank Test model is selected because we compared Indonesia and Malaysia to conduct a paired difference test of repeated measurements on a single sample to assess whether their population mean ranks differ. Our sample consist of 140 companies that getting from 713 companies listed in the Indonesia Stock Exchange while Malaysia is composed of 345 companies  from 597 listed company in Malaysia Stock Exchange. The results showed  that MERS and COVID-19 have differences in total asset turnover (TATO) and stock trading volume on the Indonesia and Malaysia Stock Exchanges, while the Current Ratio as liquidity ratio and Debt to equity ratio as risk proxy have no differences on the Indonesia and Malaysia Stock Exchange. There is no difference in the operating Profit Margin as profitability ratio variable on the Indonesia Stock Exchange while there is a significant difference on the Malaysia Stock Exchange.
THE EFFECT OF SELF REGULATED LEARNING, HIGH SCHOOL MAJORS, AND NATIONAL EXAMINATION SCORES ON ACADEMIC ACHIEVEMENT OF ACCOUNTING STUDENTS IN JAKARTA
Authors: Christanty Livia , Arifin Lidiyawati
Published: May 2022

The purpose of this research is to determine the impact of self-regulated learning (SRL), high school majors and national examination scores on academic achievement of accounting students in Universities in Jakarta. The data is collected with questionnaires with random sampling method and the samples obtained are 150 samples. The method of analysis is by using multiple linear regression. The results show that there is no significant relationship between self-regulated learning (SRL) and academic achievement (AA), high school majors (HSM) show results that have a negative and significant effect on academic achievement, while for the national examination scores (NES), it can be concluded that there is significant positive relationship between the national examination scores and academic achievement.
Neuropatías periféricas, un enfoque multidimensional y práctico de una compleja condición
Authors: Imbachí Salamanca Alex Jhonier , Chito Castro Karen Liseth , Orozco Burbano Juan David , Zamora Bastidas Tomás Omar
Published: May 2022

Introducción: las neuropatías periféricas comprenden una amplia gama de entidades que afectan uno o múltiples nervios periféricos en cualquiera de sus categorías funcionales. Métodos: revisión de la literatura sobre la temática, mediante la búsqueda de artículos en las bases de datos Pubmed y Google Scholar publicadas en los últimos 21 años, sin restricción idiomática, excluyendo estudios descriptivos y reportes de caso. Resultados: las neuropatías periféricas tienen una prevalencia del 2 % al 3 %, pueden ser causadas por etiologías infecciosas, enfermedades inflamatorias, inmunológicas, trastornos neoplásicos, exposición a tóxicos, fármacos y deficiencias nutricionales. El diagnóstico depende del juicio clínico. La aplicación de estudios de laboratorios y electrodiagnóstico pueden clasificar adecuadamente estas entidades. El tratamiento depende de la entidad subyacente y debe incluir un enfoque multimodal. Conclusiones: establecer estrategias de prevención, detección y tratamiento temprano permite una potencial recuperación y disminuye los costos para el sistema de salud.
Factores de riesgo del síndrome del trabajador quemado en médicos residentes peruanos: Análisis de la ENSUSALUD 2016
Authors: Pacovilca-Alejo Olga Vicentina , Zea-Montesinos Cesar Cipriano , Reginaldo-Huamani Rafael , Lacho-Gutiérrez Pavel , Quispe-Rojas Rodrigo , Pacovilca-Alejo Gelber Sebasti , Quispe-Ilanzo Melisa Pamela , Oyola García Alfredo Enrique
Published: May 2022

Introducción: el período de especialización de los médicos es una etapa que implica elevada prevalencia de estrés y puede desencadenar el síndrome del trabajador quemado. Objetivo: identificar los factores de riesgo del síndrome del trabajador quemado en médicos residentes peruanos. Métodos: estudio transversal analítico basado en el análisis secundario de los datos de la Encuesta Nacional de Satisfacción de Usuarios en Salud 2016, que incluyó a 332 médicos residentes que laboraban en la Provincia Constitucional del Callao y los 24 departamentos del Perú. Las variables independientes fueron obtenidas del cuestionario N° 2 y la variable dependiente se midió con la Escala de Maslach (ítem 50 en el capítulo XI del cuestionario N° 2). El análisis multivariado incluyó el modelo de regresión Poisson con varianza robusta para determinar la asociación entre las variables. Resultados: se encontró que tuvieron mayor riesgo de desarrollar el síndrome del trabajador quemado aquellos cuyo tiempo transcurrido desde la titulación hasta el momento de la encuesta era menor de seis años (RP=2,93; IC95 %=1,59-5,39) y entre 6 a 10 años (RP=2,28; IC95 %=1,21-4,30); así como en aquellos con cargas laborales que no les daba tiempo para su vida personal y familiar (RP=2,45; IC95 %=1,72-3,50), en los que manifestaron tener una enfermedad provocada o agravada por el trabajo (RP=2,21; IC95 %=1,63-2,99) y los que habían sido víctimas de amenazas en su lugar de trabajo. Conclusiones: la sobrecarga laboral que desequilibra la relación vida laboral-vida personal/familiar y el sufrimiento de violencia psicológica en el centro laboral, especialmente cuando el residente se encuentra en los primeros diez años de ejercicio profesional y en presencia de alguna morbilidad, aumentan el riesgo del síndrome del trabajador quemado.
Reseña bibliográfica: glosario ilustrado de dermatología y dermatopatología, segunda edición
Authors: Gomez Chicre Vanessa , Perez Cubides Angela
Published: May 2022

La segunda edición del Glosario ilustrado de dermatología y dermatopatología es un texto escrito por el médico especialista en Dermatopatología, Gerzaín Rodriguez Toro. El doctor Rodríguez fue docente de la Universidad Nacional de Colombia, en Bogotá, donde llegó a ser profesor titular y maestro universitario. Actualmente es profesor destacado de la Facultad de Medicina de la Universidad de La Sabana. Este texto constituye una sucesión de la labor que ha realizado el doctor Gerzaín durante décadas en el campo de la docencia médica, mediante sus múltiples publicaciones en el ámbito de la Dermatopatología.
Impacts of changing conditions on the ecological environment of the Shiyang River Basin, China
Authors: Jun Z. J. , Ming L. K. , Qiang C. Y. , Min W. , Xin P. Z.
Published: May 2022

The effect of climate change and human activities on water resources, glaciers, and land use/cover has been widely studied. The Shiyang River Basin is an important natural reserve in the Hexi Corridor of Gansu Province. Global warming and human activities have led to extreme ecological changes in this region. Exploring the response of the ecological environment of the Shiyang River Basin to a changing climate is important for studying the sustainable development of the fragile ecological environment in this basin. The meteorological data for this study was obtained from the China Meteorological Data Service Center, and the average temperature and precipitation data were acquired from four meteorological stations. By investigating the changes in the watershed climate and social environment in the Shiyang River Basin, the corresponding changes in glacial and surface water resources, landscape patterns, and natural and anthropogenic factors in the basin under changing environment were analysed. The results show that the temperature in different seasons has increased in the past 60 years, and the inclination rate of air temperature was 0.56 °C/10a. In addition, precipitation increased slightly at 0.737 mm/10a. Natural conditions and climate change have reduced the supply of glacial meltwater in the Qilian Mountains, and the regulation of glacial snow in downstream rivers is poor. The distribution of the water production rate in each river was similar to that of precipitation. The runoff modulus of the deep mountain area was greater than that of the shallow mountainous area. The western region is larger than the eastern region, and the rationalisation of the land use structure in the basin has a decisive effect on optimising the landscape pattern of the basin. The spatial evolution of the vegetation cover in the basin is generally stable; under the combined action of climate change and human activities, downstream water resources are reducing, and landscape vegetation is shifting to a high risk in the Shiyang River Basin. Among the influencing factors, anthropogenic factors play a dominant role in the runoff variation in this basin. Climate warming and unregulated human activities are the main causes of regional environmental deterioration. The study findings can contribute to understanding the coupling relationship between the natural and ecological evolution process of the inland river basin and human activities in the arid zone. Further, exploring the change trend of the ecological environment of the Shiyang River Basin can help determine the human adaptation countermeasures to mitigate ecological deterioration and ensure sustainable development of ecologically fragile areas.
Computational fluid dynamics based numerical simulations of heat transfer, fluid flow and mass transfer in vacuum membrane distillation process
Authors: Yadav Anshul , Singh Chandra Prakash , Patel Raj Vardhan , Labhasetwar Pawan Kumar , Shahi Vinod Kumar
Published: May 2022

In this study, we developed a comprehensive two-dimensional computational fluid dynamics (CFD) model using COMSOL™ Multiphysics to describe and simulate heat transfer, mass transfer and fluid flow in the flat sheet vacuum membrane distillation (VMD) under laminar flow conditions. A combination of Knudsen and Poiseuille flow was applied to study mass transfer across the membrane. The effect of variation of Reynolds number, inlet feed temperature and degree of vacuum on different parameters (mass flux, temperature polarization coefficient- TPC, concentration polarisation, heat transfer coefficient) was studied. There was a positive impact of the Reynolds number (50–200) on mass flux (13.15%), heat transfer coefficient (2.64%) and TPC (1.42%), while CPC decreased by 56.63%. The increment in the heat transfer coefficient was due to fluid mixing on the feed side, while the increment in the TPC was due to a higher temperature gradient across the membrane surfaces. The increment in the feed temperature (323–343 K) resulted in an increase in mass flux by 132.9%, while TPC decreased from 0.98 to 0.90. The degree of vacuum (640–750 mm Hg) increased mass flux and heat transfer coefficient by 72.52 and 425.83%, respectively, while the TPC decreased by 8.81%. The feed temperature was the most sensitive parameter with respect to mass flux. The developed CFD model was validated with in-house experimental results with reasonable accuracy.
High specific surface area N-doped activated carbon from hydrothermal carbonization of shaddock peel for the removal of norfloxacin from aqueous solution
Authors: Niu Xinyong , Liu Chenglin , Li Lin , Han Xiuli , Chang Chun , Li Pan , Chen Junying
Published: May 2022

A novel N-doped activated carbon (NAC) derived from shaddock peel was investigated to remove norfloxacin (NFX) from aqueous solution. The Box-Behnken central composite design (BBD) was used to optimize the preparation conditions of NAC. The specific surface area of NAC was 2,481.81 m2 g−1, which was obtained at 1,106 K activation temperature, 2.4 h residence time, and 2.3:1 mass ratio of KOH to hydrochar. Moreover, the equilibrium data were perfectly represented by Langmuir and Koble-Corrigan isotherms, and the adsorption process was precisely described by the pseudo-second-order kinetic model. Besides, the adsorption of NFX on NAC was mainly controlled by π-π electron-donor-acceptor (EDA) interaction, hydrophobic effect, hydrogen-bonding, electrostatic interaction and Lewis acid-base effect. The maximum monolayer adsorption capacity of NFX was 746.29 mg g−1 at 298 K, implying that NAC was a promising adsorbent for the removal of NFX from aqueous solution.
Can quality of life index measure oral health over the years? A systematic review
Authors: Paulo Roberto Silva  , Márcia Cristina Lopes  , Wellington M. Zaitter  , Edgard Michel Crosato
Published: May 2022

The referred quality of life has been increasingly used in dental studies to measure the impact that the dental treatment can cause on the individuals. However, there are few studies that monitor longitudinally this condition. Objective: The aim of this study was verify the behavior of the impact of the quality of life of the individuals through a systematic review on observational or interventional longitudinal studies. Literature review: The articles were selected in the period from February 5th to March 15th of 2014, with selection criteria: Objectives of the study, longitudinal studies, assessment of the quality of life of the studied population. The determination of the 24 selected articles was conducted by two examiners and revised together. Results: The study generated five tables related to common areas of dentistry: prosthesis, dental caries, geriatric health, orthodontics and oral oncology. The impact achieved in the quality of life of the people with the treatment was not maintained over the years. Conclusion: The quality of life of the individuals is little influenced by dental treatments over the years, with the exception of the cases of prosthesis and severe orthodontic treatments. The impact of the quality of life seems to be a measurement of occasional use, preferably carried soon after some oral intervention and not for longitudinal studies in which other factors cannot be controlled.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: May 2022

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Oral health status of children and adolescents victims of abuse: a literature review
Authors: Ivam Freire da Silva Júnior  , Marília Leão Goettems  , Marina Sousa Azevedo
Published: May 2022

Violence against minors can manifest in many forms and is considered a public health problem due to the physical and emotional consequences it produces. The dentist has a fundamental role in detecting victims of violence, as the face is often the most affected region. Objective: To review the national and international literature concerning injuries and most common oral conditions of children and adolescents victims of abuse. Literature review: The descriptors used were “child abuse”, “child violence”, “physical violence”, “psychological violence”, “dental caries”, and “oral health” for international databases and the corresponding terms in Portuguese for Brazilian databases, with no restriction of year of publication and language. Through the articles included in this review, it appears that children with maltreatment history presents not only high prevalence of head injuries and dental traumas, but may also have poor oral hygiene and low search for dental services and consequently higher rates of untreated caries compared with children who lived in contexts without violence. Conclusion: Although the literature suggested that children and adolescents who have suffered abuse may have worse oral health status than those who were not victims of violence, more studies are needed to understand whether there are actually significant differences in the prevalence trauma, soft tissue injuries, tooth decay, and periodontal disease among types of child abuse.
Outpatient dental treatment under general anesthesia in children with cleft lip palate: case report
Authors: Ana Clara Suplicy Diogo Santos  , Kimberlly Tennylle Vonsovicz  , Sheila de Carvalho Stroppa  , Juliana Yassue Barbosa da Silva
Published: May 2022

This study aimed to report the case of an eight-year-old patient with cleft lip and palate associated with undiagnosed syndrome presenting high level of carious lesions, difficulty on oral hygiene, no collaborative behavior and cariogenic diet. Case report: The patient underwent outpatient treatment for dental extraction and Atraumatic Restorative Treatment. Later at the following-up appointment, the child presented new active white spots and fractured restorations. Then, dental treatment under general anesthesia for amalgam restorations was indicated. Conclusion: We conclude that dental care under general anesthesia was an alternative treatment for the reported child in this clinical case that had a high prevalence of caries, cariogenic diet, loss of lip elasticity due to corrective surgeries, difficult access for oral hygiene and caregiver’s fear to toothbrush near to the cleft.
Endodontic treatment of internal root resorption: a case report
Authors: Carla Frehner Andrade  , Nathaly Dias Morais  , Luciana Stadler Demenech  , Flávia Sens Fagundes Tomazinho  , Flares Baratto-Filho  , Denise Piotto Leonardi  , Bruno Marques da Silva
Published: May 2022

Root resorption, usually found through radiographic examinations is an internal or external injury. Since root resorption is a multidisciplinary problem, it requires a variety of knowledge for understanding the etiology and pathogenesis of the disease. Objective: This study aimed to demonstrate the importance of how a correct and early diagnosis facilitates the evaluation of the best treatment for each case, assuring a favorable prognosis. Case report: A radiographic finding in a 25-year-old young male showed the presence of an internal root resorption and apical periodontitis in tooth #22. After endodontic therapy and monthly calcium hydroxide dressing changes, the root canal filling was conducted and the case was radiographically followed-up. Conclusion: An accurate initial examination, with a carefully detailed anamnesis and periapical radiographs are vital points for a correct diagnosis, treatment and,
Dental research on collective health at the Meeting of the Sociedade Brasileira de Pesquisa Odontológica (Brazilian Society of Dental Research): 14-year cut-off point
Authors: Thaisa Izidoro Zanini  , Diego Szczepanski Carraro  , Kauhanna Vianna de Oliveira  , Denise Piotto Leonardi  , Marilisa Carneiro Leão Gabardo
Published: May 2022

The Annual Meeting of the Brazilian Society of Dental Research (BSDR) is among the Brazilian prominent scientific events. Since 2001, the event has a new category, so-called Dental Research on Collective Action (DRCA). Objective: To analyze the scientific production in the DRCA category, through abstracts published in the Annals of BSDR, from 2001 to 2015. Material and methods: By active online search, the abstracts published in the Annals of BSDR from the DRCA category, from 2001 to 2015, except for 2012 (n = 771) were accessed. These were then classified by an evaluator into: year of publication (14 years), subject of research (18 categories), age of the sample or living conditions (8 categories), and region of origin (5 regions). Results: The descriptive analysis showed an average rate in DRAC category, in the 14 years analyzed, of 0.03%. The years 2006 (n = 140), 2007 (n = 113), and 2008 (n = 129) included the largest numbers of abstracts, while lower values occurred in 2009 (n = 13) and 2014 (n = 17). Concerning to the subjects, health promotion prevailed in 24.3%, followed by oral health care (18.5%), and health surveillance (11.7%). In the studies including humans (66.3%), the greater involvement was with children (27.0%). The Southeast region prevailed in the presentation of abstracts, with a rate of 66.9%, while smaller representation occurred in the Midwest region (1.6%). Conclusion: The DRCA category was present in the meetings of DRCA, especially by research involving health promotion approach with meaningful participation of the Southeast region, reflecting the potential scientific development of the region.
How to avoid legal problems in cases of nerve injury due to dental implants
Authors: Talita Lima de Castro  , Mário Marques Fernandes  , Renato Oliveira Rosa  , Rogério Nogueira de Oliveira  , Eduardo Daruge Júnior
Published: May 2022

During the surgical and implant procedures, there is considerable risk of injury to oral nerves. The dental surgeon must recognize clinical signs of the main nerve lesions that might occur following surgical or dental implant procedures, and take the necessary precautions to prevent them. Objective: The aim of this manuscript was to describe a legal case of clinical paresthesia due to alveolar nerve compression following an implant placement, revising the types of nerve lesions of surgical-implant etiology, and advise the dental professional against clinical and legal flaws. Case report: In this case, a female patient underwent oral rehabilitation, including the placement of an osseointegrated implant in the lower left first molar region. After the setting of the device, the patient presented paresthesia on the left mentonian region and buccal mucosa of elements 34, 33 and 32 and, dissatisfied with the situation, she appealed to justice and requested the responsibility of the professional. Conclusion: It is important to discuss that prevention continues to be the key issue when it comes to avoiding clinical, ethical or legal repercussions. Practicing adequate diagnosis and treatment planning and conducting the necessary complementary exams are essential, allied to previously patients’ signed consent.
Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking
Comparison of Fruit Fly Gut and Human Cytochrome P450s
Authors: Nirusimhan Vijay , Andrew Gideon Daniel , Parashar Abhinav , Jeyachandran Sangavi , Jeyaraman Jeyakanthan , Subbaraj Gowthamkumar , Kulanthaivel Langeswaran
Published: May 2022

Drosophila melanogaster is a prominent organism in developmental biology research and in studies related
to pathophysiological conditions like cancer and Alzheimer’s disease. The fruit fly gut contains several cytochrome
P450s (CYP450s), which have central roles in Drosophila development and in the normal physiology of the
gut. Since the crystal structures of these proteins have not been deciphered yet, we modeled the structure of 29 different
D. melanogaster gut CYP450s using Prime (Schrödinger). The sequences of chosen D. melanogaster gut
CYP450s were compared with that of their human counterparts. The common gut (and liver) microsomal CYP450s
in humans were chosen for structural comparison to find the homology and identity % of D. melanogaster CYPs
with that of their human counterparts. The modeled structures were validated using PROCHECK and the best fit
models were used for docking several known human pharmacological agents/drugs to the modeled D. melanogaster
gut CYP450s. Based on the binding affinities (ΔG values) of the selected drug molecules with the modeled fly gut
CYPs, the plausible differences in metabolism of the prominent drugs in humans and flies were projected. The gut is
involved in the absorption of oral drugs/pharmacological agents, and hence, upregulation of intestinal CYP450 and
their reactions with endobiotics and xenobiotics is envisaged. The insights gleaned from this work can validate D.
melanogaster as a model organism for studying intestinal drug metabolism, particularly in the context of a) toxicology
of pharmacological agents to the gut cells and b) how gut P450 metabolites/products can influence gut homeostasis.
This work can help establish a platform for further in vitro investigations on how intestinal CYP450 metabolism
can influence gut health. The data from this work can be used for further in silico studies and this work can serve as a
platform for future in vitro investigations on intestinal CYP450-mediated metabolism of endo- and xeno-biotics in D.
melanogaster.
An Updated and Focused Review on Heterocyclic Inhibitors for SARSCoV and SARS-CoV-2 3CLpro
Authors: Alam Ozair , Manaithiya Ajay , Mittal Shruti , Naim Mohd. Javed , Imran Mohd. , Alshrari Ahmed Subeh , Sheikh Aadil A. , Khan Imran A.
Published: May 2022

Background:

SARS-CoV and SARS-CoV-2 are exceedingly contagious and typically result in major respiratory illnesses (acute respiratory syndrome). The public health is facing enormous challenges across all the nations due to these newly emerging pathogens. Reliable and systematic examination of SARS-CoV and COVID-19 will assist in identifying infectious persons accurately. Based on the biological, chemical, and genetic link of SARS CoV-2 towards SARS-CoV, the recurrence of different anti-SARS-CoV natural drug molecules may be beneficial in the advancement of anti-COVID-19 herbal drug molecules. Here in this review, we evaluated SAR research that has recently been published as well as molecular docking analysis of previously synthesised compounds that have been targeted against SARS-CoV and SARS-CoV-2, respectively. This investigation might assist scientists in creating novel and revolutionary molecules that could target SAR-CoV-2.

Objectives:

The review highlights the heterocyclic inhibitors' ability to successfully inhibit SARSCoV and SARS-CoV-2. The meticulously described structure-activity relationship of potential SARS-CoV and SARS-CoV-2 inhibiting compounds has been addressed in this review.

Evidence acquisition:

We conducted a thorough literature assessment employing electronic databases for scientific articles highlighting potential heterocyclic inhibitors for SARS-CoVand SARSCoV- 2, published from 2010 to 2021. We recovered 415 articles, but only 220 were involved and conversed in this manuscript. The article apprehended appropriate research considering three areas: 1) SAR activity, 2) Molecular docking, and 3) Biological activity and future prospects on SARS-CoV-2.

Methods:

The potential compounds with decent inhibitory activity have been discussed and reviewed along with their inhibition potential, expressed in terms of IC50 value.

Results:

Heterocyclic scaffolds reflect an extensive spectrum of therapeutic activity and might function as an initiating concept for the designing and discovery of potential inhibitors for SARS-CoV and SARS-CoV-2 treatment.

Conclusion:

The points highlighted here may prove to be a vital tool for medicinal chemists working/ investigating more potent and efficacious scaffolds in treating SARS-CoV and SARS-CoV-2.
Synthetic Approaches and Pharmacological Attributes of Benzosuberone
Skeleton
Authors: Bukhari Syed Nasir Abbas
Published: May 2022

Background:

Benzocycloheptanone is the main structural feature of numerous famous
natural pharmacophores such as Colchicine and Theaflavins. It has gained popularity in the field
of medicinal chemistry, attributing to its broad-spectrum effect.

Objective:

Numerous research publications addressing the derivatization of the benzosuberone
molecule have been published, and their biological and pharmacological features have been extensively
addressed. Numerous derivatives have been discovered as lead compounds for the development
of novel medications. Thus, the goal of this article is to summarize and analyze all
published findings on the synthesis and biological assessment of the benzosuberone skeleton.

Methods:

All main databases including SciFinder, PubMed and google scholar were used with
appropriate keywords to select related reported literature, and further bibliography in related literature
was also used to find linked reports.

Results:

Synthetic routes to benzosuberone-based ring systems were identified from the literature
and explained stepwise and after this, pharmacological activities of all benzosuberone derivatives
are listed target-wise and a detailed structure-activity relationship is developed.

Conclusion:

The current review discusses numerous synthetic approaches for the synthesis of
benzosuberone skeleton and its applications in many domains of medical chemistry. Compounds
possessing the benzosuberone skeleton play an important role in the drug development process
due to their wide range of biological actions such as anti-cancer, antibacterial, antifungal, antiinflammatory,
and so on. The results of antibacterial screening and Structure-Activity Relationship
(SAR) revealed that the compounds containing this skeleton with the piperazine and morpholine
rings have antimicrobial potential when compared to the commercial antibiotic Norfloxacin.
Despite extensive study to date, there is still room for the development of novel and efficient
pharmacophores using the structure-based drug design technique.
Current Views on Oncolytic Adenoviruses for Cancer Therapy
Authors: Bhattacharya Sankha
Published: May 2022

Oncolytic viruses replicate and spread in tumors at the same time, resulting in increased cytotoxicity and the reversal of tumor immune suppression. Among other viruses, recombinant adenoviruses that replicated in tumor cells were clinically tested via intratumoral or systemic administration. Although oncolytic virus replication kills tumor cells on its own, it may also activate the immune system, which can aid in tumor control. Viruses can be modified to improve their selectivity and effectiveness. Adenovirus genomes can be easily designed to incorporate various tumor-targeting pathways and therapeutic transgenes to improve antitumor properties. Poor tumor targeting, intratumoral expansion, and virocentric immune responses are all linked to low efficacy. As a result, more effective oncolytic adenoviruses that can be used alone or in combination with chemotherapy or immunotherapy are needed. Oncolytic Adenovirus (OAds) has long been considered a potential biotherapeutic agent against various cancers due to its ability to replicate cancer cells while remaining dormant in healthy cells selectively. Several preclinical studies using genetic engineering technology have increased antitumor OAds in various cancers in recent years. Systemic OAds administration is hampered by poor targeting tropism to healthy tissues, low-level ad receptors on tumor cells, and pre-existing neutralizing antibodies. Various discoveries have been made to overcome these barriers, including stem cells, nanoparticles, polymer shielding, extracellular vesicles, hydrogels, and microparticles (MPs). These carriers may improve Oncolytic viruses’ therapeutic efficacy by improving transfection, circulatory survival, cellular interactions, specific targeting, and immune response. The structure and biology of adenoviruses, the different types of OAds, and the efficacy of different carriers in the systemic administration of OAds were all examined in this review.
Low-Carbohydrate Ketogenic Diet for Improvement of Glycemic Control:
Mechanism of Action of Ketosis and Beneficial Effects
Authors: Das Srijit , Sakr Hussein F. , Sirasanagandla Srinivasa R. , Bima Abdulhadi I. , Elsamanoudy Ayman Z.
Published: May 2022

The incidence of metabolic syndrome and diabetes mellitus is increasing globally. A diet
rich in carbohydrates increases the hyperglycemic state. While considering the lifestyle changes
to combat life-threatening diseases, there is an effort to decrease the daily intake of carbohydrates.
A low-carbohydrate diet also makes the body rely more on fat for energy, so there is less fat accumulation.
A diet is considered to be low-carbohydrate ketogenic if the intake is ≤ 50 g per day. The
‘low -carbohydrate ketogenic diet’ (LCKD) produces ketosis. LCKD contains high-fat, moderateprotein,
and low-carbohydrate components. The main objectives of the present review are to discuss
insulin resistance in different viscera of the body, describe the role of adipokines in insulin resistance,
understand the mechanism of ketogenesis, and determine the impact of LCKD in overcoming
insulin resistance in the body. In the present review, we also highlight the beneficial effects
of LCKD in metabolic, neurodegenerative, cardiovascular, and lipid disorders and discuss the effect
on longevity and aging. LCKD may help in combating the morbidity and mortality arising
from the above-mentioned diseases and also help in leading a better quality of life.
Radiologic and Pathologic Findings of Axillary Intraductal Papilloma
Arising in Accessory Breast Tissue: A Case Report and Literature Review
Authors: Eun Yang Go , Bae Seong Jae
Published: May 2022

Introduction:

This is a rare case report of axillary intraductal papilloma arising in accessory breast tissue.

Case presentation:

A 49-year-old woman presented to our clinic with a palpable right axillary mass that had first appeared 6 months earlier. Mammography and ultrasonography of right axilla revealed ovoid mass surrounding accessory breast tissue. Ultrasound-guided 14-G core-needle biopsy was performed, and pathologically revealed intraductal papilloma without atypia.

Conclusion:

If radiological finding reveal suspicious lesions in axillary breast tissue, core-needle biopsy can be performed for diagnosis because ectopic breast tissue is same spectrum of pathologic processes that occur in normal breast tissue.
Elucidating the Role of Trauma and Significant Life Stress in the Disease
of Addiction may Provide New Targets for Medication Development
Authors: Sagrera Caroline E. , Alderman Laura , Vest M. Frances , Goeders Nicholas E. , Murnane Kevin S.
Published: May 2022

The role of previous life stress and trauma in addiction has been understudied and underappreciated.
To date, much previous research has emphasized other aspects of the disease of addiction,
including the reward-based neural circuitry. While previous research has offered tremendous value and
shaped human understanding of addiction, an increased emphasis on the role of stress and trauma in
addiction may provide new targets for therapeutic development. Here, we review both clinical and preclinical
literature in support of the hypothesis that addiction is largely initiated and driven by significant
previous life stressors and traumas. We describe some of the available quantitative molecular in
vitro studies, systematic literature reviews, case-control studies, and cross-sectional studies to summarize
the neurobiology of the reward pathway, the influence of stress-related hormones on the brain, and
the role of childhood trauma in the development of substance abuse. The current perspective highlights
the importance of early intervention during stressful life events for the prevention of future addiction
behavior and suggests that elucidating the neurobiology of these systems may provide new targets for
medication development for addiction.