bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple Congenital Anomalies: Meningoencephalocele, Labiopalatoschisis and Clubfoot with Normal Chromosomal Analysis
Authors: Samosir Sefty M. , Rachmiawaty Angghea , Fatati Ita , Aziz Alamsyah
Published: July 2022

Objective : To perform chromosomal microarray when similar case was found.Methods: Case reportCase : G1P0A0, 20 years-old, 23-24 weeks gestation, normal BMI, was diagnosed by ultrasonography with multiple congenital anomaly consisted by  meningoencephalocele, labiopalatoschisis, and clubfoot. Amniocentesis was performed to manage karyotyping analysis and a result of 46 XY was obtained. Neonate was delivered with exact condition according to prenatal diagnosis and was demised 6 hours postnatal. Patient had no history of smoking or DM, and no familial congenital deformity. Patient was a worker in textile manufactory and inadequacy folic acid intake during pregnancy was known.Early suspicion of aneuploidy as cause of multiple congenital anomalies in this case was not proven otherwise. Serology test also found no congenital infection. Literature research indicated tendency of MTHFR polymorphisms. Genetic analysis such as chromosomal microarray to establish involvement of MTHFR polymorphism is needed.Conclusion : This case should behold as clinicians’ consideration to perform additional examination and patients counseling when similar anomaly was found during prenatal ultrasonography examination.Keyword : chromosomal microarray,karyotyping; MTHFR polymorphism, mutiple congenital anomaly.

 

Abstrak

Tujuan : Untuk melakukan pemeriksaan chromosomal microarray  pada kasus yang sama.Metode:  Laporan kasus.Kasus : G1P0A0, usia 20 tahun, hamil 23-24 minggu, didiagnosis secara ultrasonografi dengan kelainan kongenital multipel berupa meningoensefalokel, celah bibir-palatum, dan club foot. Amniosentesis dilakukan pada pasien untuk analisis kromosom dan didapatkan hasil 46 XY. Bayi lahir dengan kondisi yang sama dengan diagnosis prenatal tersebut dan meninggal 6 jam pasca salin. Dari hasil anamnesis dan pemeriksaan kami dapatkan pasien bukan perokok, tidak ada keluarga dengan cacat bawaan, indeks masa tubuh  pasien normal. Pasien merupakan karyawan pabrik tekstil dan pasien  tidak mengkonsumsi asam folat adekuat selama kehamilan. Dua data terakhir yang kemungkinan berkontribusi terjadinya kelainan kongenital multipel pada kasus ini, yaitu kontak dengan teratogen dan defisiensi asam folat. Dugaan awal kelainan kromosom sebagai penyebab kelainan kongenital multipel pada kasus ini tidak terbukti. Sayangnya, investigasi-investigasi lebih lanjut berupa analisis genetik, seperti pemeriksaan  apakah terdapat  polimorfisme MTHFR yang berhubungan dengan defisiensi asam folat pada kasus ini tidak dilakukan karena keluarga pasien menolak. Kesimpulan : Kasus ini sebaiknya menjadi bahan pertimbangan klinisi untuk melakukan pemeriksaan tambahan dan edukasi ke pasien pada saat menemukan kelainan yang sama pada pemeriksaan ultrasonografi prenatal.Keyword: chromosomal microarray; karyotyping; multipel kongenital anomali; polimorfisme MTHFR
Progress of Labor Onset with Combination of Pregnancy Massage and Acupressure
Authors: Khanifah Milatun , Nur Chabibah , Khuzaiyah Siti
Published: July 2022

Abstract

Objective: To investigate effectiveness of complementary therapy combination pregnancy massage and acupressure on the onset of labor in primigravida pregnant women.

Methods: The population was pregnant women in all regions of Pekalongan Regency at more than 39 weeks' gestation, using random cluster sampling. Data collect use an observation sheet to measure the start time of labor and also check the implementation of massage and acupressure in pregnancy. Treatment was carried out every 2-3 days from 39 weeks of gestation until labor occurs. This study was quantitative quasi-experimental with control group design with a cohort approach.

Results:   The results of the bivariate analysis showed that there were significant differences in the onset of childbirth in the intervention group with the control group (p-value; 0.003; CI -8.59 - (- 2.07)). It was concluded that complementary therapy combined therapy of pregnancy massage and acupressure could be used as an alternative therapy to prevent overdue pregnancy

Conclusions:   These findings confirm that complementary therapy combination pregnancy massage and acupressure could faster the onset of labor.

Keywords: acupressure, complementary therapy, onset  labor, pregnancy massage.

 

Abstrak

Tujuan: Untuk mengetahui efektivitas terapi komplementer kombinasi pijat kehamilan dan akupresur pada permulaan persalinan pada ibu hamil primigravida.

Metode: Populasi dalam penelitian ini adalah ibu hamil di seluruh wilayah Kabupaten Pekalongan dengan usia kehamilan lebih dari 39 minggu, dengan menggunakan sampel cluster random. Pengumpulan data menggunakan lembar observasi untuk mengukur waktu mulai persalinan serta memeriksa pelaksanaan pijat dan akupresur pada kehamilan. Pengobatan dilakukan setiap 2-3 hari dari usia kehamilan 39 minggu sampai terjadi persalinan. Penelitian ini merupakan penelitian kuasi eksperimental kuantitatif dengan desain kelompok kontrol dengan pendekatan kohort.

Hasil: analisis bivariat menunjukkan terdapat perbedaan yang signifikan timbulnya persalinan pada kelompok intervensi dengan kelompok kontrol (p-value; 0,003; CI -8,59 - (- 2,07)). Disimpulkan bahwa terapi komplementer terapi kombinasi pijat kehamilan dan akupresur dapat digunakan sebagai terapi alternatif untuk mencegah terjadinya kehamilan terlambat.

Kesimpulan: Temuan ini mengkonfirmasi bahwa terapi komplementer kombinasi pijat kehamilan dan akupresur dapat mempercepat terjadinya persalinan.

Kata kunci: akupresur; awalan persalinan, pijat kehamilan ,terapi komplementer.
The Role Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA
Authors: Naeny Fajriah  , Chalid Maisuri T. , Lisal Lenny , Lukas Efendi , St. Nur Asni  , Rina Masadah
Published: July 2022

Abstract

Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood.

Methods: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining.

Results: 16 of 38 samples were acquired from mothers aged 26-30 years-old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000).

Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. 

Keywords: HBV DNA, Hepatitis B, intrauterine infection, placental toll-like receptor (TLR) 7,umbilical cord.

 

Abstrak

Tujuan: untuk melihat peran ekspresi TLR-7 terhadap transmisi vertikal intrauterina pada kehamilan melalui identifikasi marker serum hepatitis B pada darah ibu dan talipusar.

Metode: Analisis ekspresi TLR dilakukan pada 38 sampel blok paraffin jaringan plasenta ibu yang menderita HBV dengan memakai pewarnaan imuhohistokimia TLR.

Hasil: 16 dari 38 sampel berusia 26-30 tahun. Sebagian besar sampel merupakan kelompok primipara (52.6%). Penelitian ini tidak menemukan hubungan yang signifikan antara ekspresi TLR-7 di plasenta dan HBV DNA darah tali pusat (p = 1.000). Tapi, kami menemukan hubungan yang signifikan antara ekspresi TLR-7 plasenta dan HBV DNA ibu (p = 0,034). Sedangkan HBeAg dan HBV DNA plasenta tidak berhubungan dengan ekspresi TLR-7 plasenta (p = 0,082; p = 1.000).

Kesimpulan: Tidak ada hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV di plasenta dan tali pusat, tetapi kami menemukan hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV ibu. 

Kata kunci: HBV DNA, Hepatitis B, infeksi intrauterina, plasenta, tali pusat,  toll-like receptor (TLR) 7
Vaginal Microorganism Pattern in Premature Rupture of Membrane
Authors: Vanya vanesha  , Wantania John J. E , Lengkong Rudy A.
Published: July 2022

Objective: To determine the pattern of vaginal microorganisms in pregnant women and risk factors for premature rupture of membranes (PROM) in Manado.Methods: This is a case-control study. Samples was 40, divided into 20 pregnant with PROM and 20 control samples. Samples were taken from Kandou Manado Hospital and network hospitals within the inclusion criteria. Samples were taken from vaginal swab for microorganism culture.Results: The highest age distribution in the case of PROM was in the reproductive age group of 20-35 years, 19 people (95%, p = 1,000). Primiparas were dominant in the PROM were 11 people (55%, p = 0.204). The distribution of BMI mostly from the overweight and obesity groups of 11 people (55%, p = 0.527). In the PROM, 19 people (95%, p = 0.605) did not smoke. Escherichia coli was the most microorganisms in swab vaginal of PROM: 7 people  (29.17%).Conclusion: The most microorganisms found in PROM are Escherichia coli, Enterobacter cloacae and Staphyloccocus aureus and in non-PROM are Klebsiella oxytoca, Staphylococcus epidermidis, Staphylococcus saprophyticus and Pseudomonas fluorescens. There was no relationship between BMI, age, parity, smoking, and gestational age with the incidence of PROM in this study.Keywords: PROM , vaginal microorganisms pattern,  vaginal swab.

 

Abstrak

Tujuan: Untuk mengetahui pola mikroorganisme vagina pada kultur vaginal swab wanita hamil dan faktor risiko pada KPD di Kota Manado.Metode : Studi ini bersifat case control. Total sampling 40 sampel dibagi menjadi 20 sampel hamil dengan KPD dan 20 kontrol. Sampel diambil dari RSUP Kandou Manado dan RS jejaring yang memenuhi kriteria inklusi. Semua pasien dilakukan pengambilan sampel swab vagina untuk dilakukan kultur mikroorganisme.Hasil : Hasil sebaran usia pada KPD paling banyak pada usia reproduksi 20-35 tahun yaitu 19 orang (95%, p = 1,000). Primipara dominan pada KPD yaitu 11 orang (55%, p = 0,204). Hasil sebaran IMT paling banyak kelompok overweight dan obesitas yaitu 11 orang (55%, p = 0,527). Pada KPD sebanyak 19 orang (95%, p = 0,605) tidak merokok. Mikroorganisme terbanyak pada swab vagina KPD adalah Escherichia coli sebanyak 7 orang (29,17%). Kesimpulan: Mikroorganisme terbanyak pada KPD adalah Escherichia coli, Enterobacter cloacae dan Staphyloccocus aureus dan pada non KPD adalah Klebsiella oxytoca, Staphylococcus epidermidis, Staphylococcus saprophyticus  dan Pseudomonas fluorescens. Tidak ada hubungan antara IMT, usia, paritas, merokok, dan umur kehamilan dengan kejadian KPD pada penelitian ini.Kata kunci: pola mikroorganisme vagina, ketuban pecah dini, swab vagina.
СУЧАСНА ТЕОРІЯ ТА ПРАКТИКА ПІДГОТОВКИ ЗДОБУВАЧІВ ВИЩОЇ ОСВІТИ СТУПЕНЯ ДОКТОРА ФІЛОСОФІЇ У ВИЩИХ ВІЙСЬКОВИХ НАВЧАЛЬНИХ ЗАКЛАДАХ НА ЗАСАДАХ МЕТОДОЛОГІЧНОЇ КУЛЬТУРИ
Authors: Козубцов Ігор , Козубцова Леся , Хлапонін Юрій
Published: July 2022

В статті проаналізовано особливості організації науково-педагогічних експериментів у вищих військових навчальних закладах з підготовки ад’юнктів. Дослідження обумовлено недостатньою увагою вчених до обговорення питання реформування, модернізації системи підготовки наукових та науково-педагогічних кадрів для потреб Збройних Сил України через ад’юнктуру. Проаналізовано вищі навчальні закладі та визначено в яких здійснюється підготовка ад’юнктів за науковою спеціальністю 13.00.04 – «Теорія і методика професійної освіти». Проаналізовано вищі навчальні закладі за яким зареєстровано наукові журнали з метою з’ясування можливості апробації наукових результатів за напрямком педагогічні науки. В рекомендаціях надано пропозицію щодо доцільності у всіх фахових наукових журналах запровадити окрему рубрику дослідження в галузі військової освіти та зараховувати як фахову публікацію здобувачам вченого ступеня доктора філософії та доктора наук з галузі педагогічних наук. Привернуто увагу на показник рівень розвиненості методологічної культури ад’юнктів як кількісний показник коефіцієнта готовності ад’юнктів до організації професійної діяльності.
МОТИВАЦІЙНА ПРОМОВА КОМАНДИРА ЯК ЗАСІБ ФОРМУВАННЯ ПСИХІЧНОЇ СТІЙКОСТІ ВІЙСЬКОВОСЛУЖБОВЦІВ ТА СПОНУКИ ДО ДІЇ
Authors: Красницька Ольга
Published: July 2022

Стаття присвячена ролі мотиваційної промови командира у формуванні та підвищенні психічної стійкості військовослужбовців, зокрема під час ведення бойових дій. Розкрито сутність мотиваційної промови як засобу формування готовності воїнів до боротьби, роботи в деприваційних умовах, подолання страху, вияву сміливості й мужності, спонукання до дій та вчинків, підняття бойового духу, мобілізації інтелектуальних, фізичних і поведінкових ресурсів, використання військовослужбовцями всіх своїх можливостей під час виконання бойового завдання для досягнення цілі. Визначено функції мотиваційної промови (лідерська, емоційна, згуртування, спонукально-вчинкова, мобілізаційна, результативна, піднесено-підкріплююча) та розкрито вимоги до неї. Психічну стійкість представлено як запоруку ефективності виконання завдань.
АНАЛІЗ ІСНУЮЧИХ СИСТЕМ ОЦІНЮВАННЯ ВІЙСЬКОВО-СЛУЖБОВЦІВ В АРМІЯХ ФРАНЦІЇ, ВЕЛИКОБРИТАНІЇ, США
Authors: Рибидайло Анатолій , Прокопенко Олександр , Уварова Тетяна , Руденська Галина , Цимбал Ірина
Published: July 2022

Оцінювання (атестація) особового складу є невід’ємною процедурою формування кар’єри військовослужбовця. Підґрунтям для здійснення організаційно-штатних заходів є результати оцінювання військовослужбовців. У статі наведено аналіз існуючих систем оцінювання військовослужбовців в арміях Франції, Великобританії та США для визначення прийнятних практик щодо впровадження у діяльність кадрових органів Збройних Сил України.

Досліджено порядок, терміни і основні критерії оцінювання особового складу та проаналізовано особливості кадрового менеджменту стосовно прийняття військовослужбовців на службу, їх підготовки, призначення на посади (використання на посаді), подальшого розвитку, мотивації та виходу у відставку або завершення служби.
ПІДХОДИ ТА МЕТОДИ TALENT MANAGEMENT У СТРАТЕГІЇ УПРАВЛІННЯ КАДРОВИМИ РЕСУРСАМИ ЗБРОЙНИХ СИЛ УКРАЇНИ
Authors: Цевельов Олег , Оліферук Володимир , Кітура Олег
Published: July 2022

Система управління талантами (Talent management system, TMS) – це інтегрований програмний продукт, який представляє автоматизовані інструменти для вирішення завдань в чотирьох ключових областях: підбор и залучення; управління ефективністю; навчання та розвиток; а також формування заходів заохочення та популяризації. У цій системі під час планування кар’єри потрібно враховувати наступне, а саме – які навички та вміння потрібні кандидату в майбутньому, а не лише зараз. Адже успіх розвитку військового колективу значною мірою залежить не тільки від високого рівня готовності й умінь діяти в бойовій обстановці, а й від ефективності використання особистих якостей військовослужбовців, які є рушійною силою будь-якого військового підрозділу та важливим складником досягнення їм високих позицій з виконання поставлених завдань та результативності підрозділу і військового колективу у цілому.

На сьогодні існують масштабні автоматизовані продукти для планування кар’єри, розроблені з урахуванням необхідності постійного моніторингу та оцінки кандидатів на ключові позиції на проміжних етапах. Але таку систему потрібно побудувати самостійно саме для Збройних Сил України та інших військових формувань враховуючи їх досвід формування, підготовки, оснащеності та внутрішньої культури військових колективів й укладу життя. Отже, виникає потреба побудови нової системи управління персоналом, основою якої стане орієнтація на таланти, оскільки управління талантами (Talent Management) – це повний спектр кадрових процесів для залучення, адаптації, розвитку, мотивації та утримання високоефективних спеціалістів у військовій сфері. Управління талантами спрямоване на підвищення ефективності військових процесів за допомогою тренувань і практики (навчань), які роблять особовий склад підрозділу більш продуктивним та цілісним.
ОСОБЛИВОСТІ ФОРМУВАННЯ ВІЙСЬКОВОГО КАДРОВОГО ПОТЕНЦІАЛУ ЗБРОЙНИХ СИЛ УКРАЇНИ ІЗ ЗАЛУЧЕННЯМ ІНОЗЕМНИХ ІНСТРУКТОРІВ-ВИКЛАДАЧІВ
Authors: Зельницький Андрій , Заболотний Олег , Васильєв Олександр , Корнієнко Валерій
Published: July 2022

У статті розглянуто сутність, структуру і зміст процесу формування і нарощування кадрового потенціалу Збройних Сил України в системі професійної військової освіти із залученням іноземних інструкторів-викладачів. Проаналізовано та уточнено категоріальний апарат і нормативно-правову базу щодо професійної підготовки військовослужбовців та представлено результати реалізації механізмів взаємодії ЗСУ з іноземними тренувальними місіями щодо формування в офіцерів визначених компетентностей та професійно важливих якостей.
ТЕОРЕТИЧНІ АСПЕКТИ ІННОВАЦІЙНОГО РОЗВИТКУ ВІЙСЬКОВОЇ ОСВІТИ
Authors: Васильєв Олександр
Published: July 2022

У статті проаналізовано теоретичні аспекти інноваційного розвитку військової освіти, особливості інноваційної політики та інноваційної діяльності у сфері військової освіти. Розглянуто суперечності внутрішнього та зовнішнього впливу на інноваційний розвиток військово-освітнього процесу. Визначено зміст етапів реалізації інноваційних перетворень у системі підготовки військових фахівців.
The influence of chamomile and nettle addition in broiler feed mixtures on meat quality
Authors: Prakatur Ivana , Domaćinović Matija , Pastuović Ljubica , Đidara Mislav , Ronta Mario , Samac Danijela , Pavić Vulinović Mirela
Published: July 2022

Cilj ovog istraživanja bio je utvrditi utjecaj dodatka kamilice i koprive kao prirodnih dodataka u hranidbi tovnih pilića na kvalitetu njihova mesa. Istraživanje je provedeno na 120 jednodnevnih pilića hibrida Ross 308, podijeljenih u 4 skupine. Kontrolna (K) skupina bez prirodnih dodataka u kompletnoj krmnoj smjesi te tri pokusne skupine (P1, P2, P3): P1 skupina uz dodatak 2 % koprive, P2 uz dodatak 2 % kamilice te P3 uz dodatak 1 % koprive + 1 % kamilice u kompletnim krmnim smjesama. Tov pilića trajao je 6 tjedana. Od 1. do 21. dana istraživanja pilići su bili hranjeni standardnom krmnom smjesom starter (22,05 % sirovih bjelančevina), a od 22. do 42. dana istraživanja krmnom smjesom finišer (20,18 % sirovih bjelančevina). Istraživanjem je utvrđeno kako je pokusna skupina P3 imala statistički značajno niže žive mase i mase trupa u odnosu na K, P1 i P2 skupinu pilića (P<0,01). Uz to utvrđeno je kako je postojala statistički značajna razlika u udjelima leđa sa zdjelicom između P3 i K skupine pilića (P<0,005) te statistički značajna razlika u udjelu vrata između K i P2 skupine pilića (P<0,005). Postojala je statistički značajna razlika (P<0,05) u vrijednostima pH1 i pH2, u vrijednostima boje kože CIE a* (P<0,05) i CIE b* (P<0,01) te boji mesa u CIE L* (P<0,05) parametru, dok kod kemijskog sastava pilećih prsa nije utvrđena statistički značajna razlika između kontrolne i pokusnih skupina niti kod jednog promatranog pokazatelja. Istraživanje je potvrdilo moguću primjenu kamilice i koprive kao prirodnih dodataka u hranidbi pilića jer spomenuti prirodni dodatci svojim bioaktivnim komponentama učinkovito djeluju na pigmentaciju kože što takve proizvode čini potencijalno privlačnijim krajnjim potrošačima te utječe na njihov odabir i odluku o kupnji upravo takvih proizvoda.
MISOPHONIA: SYMPTOMS, COMORBIDITIES AND PERSPECTIVES OF INTERVENTION. FROM THEORY APPROACH TO INTEGRATED CLINICAL PRACTICE RESEARCH
Authors: Rosenthal Zachary M. , Annarumma Maria , Sessa Francesco , Consalvo Iris , De Masi Valerio , Pagano Luana
Published: July 2022

Recent scientific studies have noted that misophonia is a complex neurophysiological and behavioural syndrome characterised by high physiological and emotional reactivity, resulting from an intolerance to specific auditory stimuli. People with this distress have emotional and behavioural responses, excessive in relation to the auditory stimulus that provokes them; in fact, these people may have outbursts of anger, severe anxiety crises, and even panic attacks. One of the questions that the first studies of this syndrome have asked was what link occurred between misophonia and certain psychological disorders such as anxiety, depression, and personality disorders. Another important research objective was to examine the differential diagnosis between misophonia and hearing disorders such as tinnitus. In view of the current literature on misophonia, it has become important to define the comorbidity and differential diagnosis of misophonia with other disorders. The next step is, through further research on clinical cases, to define the most effective psychotherapeutic techniques on misophonic symptoms, and the psychoeducational tools needed to intervene in family systems with misophonic patients.
Keywords: comorbidity, differential diagnosis, psychological disorders, hearing disorders, misophonia, behavioural response, emotional response, psychoeducational tools, psychotherapeutic techniques
Obtención de queso mozzarella, mediante el diseño de un proceso industrial, en la provincia de Chimborazo, cantón Colta
Authors: Borja Mayorga Danielita Fernanda , Chuiza Rojas Marco Raul , Andrade Avalos Mónica Lilian
Published: July 2022

Introducción. La industrialización de un proceso permite obtener un producto en menor tiempo y se asegura la calidad de este con lo establecido en la norma NTE INEN 82: Queso mozzarella. Requisitos. Objetivo. Diseñar un proceso industrial para la obtención de queso mozzarella en la planta procesadora “SIERRALAC” perteneciente a la Corporación de Organizaciones Campesinas e Indígenas de las Huaconas y Culluctus (COCIH), en la Provincia de Chimborazo, Cantón Colta. Metodología. Se inició con la caracterización de la materia prima, mediante análisis fisicoquímicos y microbiológicos basados en la NTE INEN 0009: 2012. Leche cruda. Requisitos. NTE INEN 9:2012. Además, se realizó pruebas para identificar las variables de operación para la elaboración de queso mozzarella a nivel de laboratorio arrojando los siguientes resultados: temperatura de pasteurización a 65 °C durante 30 minutos, temperatura de enfriamiento a 40 °C, tiempo de acidificación de 2-3 horas, pH ideal entre 5,2-5,4 para la etapa de hilado, temperatura de hilado a 65 °C y tiempo de salado de 3 horas. Para cumplir con los requerimientos de la microempresa se empleó el método de fermentación enzimática debido a su alto rendimiento y calidad del producto. Resultados. En base a los valores de las variables de operación se realiza el diseño de los equipos a escala industrial, cuyos equipos son: una marmita con un sistema de agitación, un tanque de hilado, una lira y una mesa de moldeo para una capacidad de procesamiento de 500 litros de leche. Conclusión. La validación del diseño de ingeniería se efectuó mediante la caracterización físico, bromatológico, y microbiológico de queso mozzarella de acuerdo con la norma NTE INEN 82: Queso mozzarella. Requisitos, cuyos resultados cumplen con los parámetros de calidad siendo apto para su consumo. Mediante un estudio de análisis financiero se verificó que el proyecto es viable, para garantizar la inocuidad del producto se recomienda aplicar buenas prácticas de manufactura.
Characteristics of the number and legal status of children of the Khabarovsk Specialized Orphanage as an indicator of the social well-being of the population of Khabarovsk
Authors:   The Khabarovsk Specialized Orphanage of the Health Ministry of the Khabarovsk Krai, Petukhova G.M. , Nikolaevskaya T.I. ,   The Khabarovsk Specialized Orphanage of the Health Ministry of the Khabarovsk Krai, Levchenko S.S. ,   The Khabarovsk Specialized Orphanage of the Health Ministry of the Khabarovsk Krai, Ponomarenko E.Yu. ,   The Khabarovsk Specialized Orphanage of the Health Ministry of the Khabarovsk Krai
Published: July 2022

The article presents the data on the number and legal status of children in the Khabarovsk Specialized Orphanage for the period 2011–2020. The dynamics of the number of children was studied. Attention is drawn to the changes that have taken place in the structure of the legal status of children and the options for their family arrangement.
Environmental management education using immersive virtual reality in asthmatic children in Korea: a randomized controlled study (secondary publication)
Authors: Kim Seung Hyun , Park Sang Hyun , Kang Insoon , Song Yuyoung , Lim Jaehoon , Yoon Wonsuck , Yoo Young
Published: July 2022

Awareness of environmental control is considered a significant influence on the performance of asthma self-management behaviors, which are involved in maintaining effective asthma control. This study aimed to investigate whether immersive virtual reality (VR) education is effective in environmental control education for asthmatic children in Korea. Thirty asthmatic children aged 9 to 13 years with aeroallergen sensitization were enrolled. Environmental control education for asthmatic participants was performed using immersive VR (VR group) or conventional leaflets provided by asthma specialists (control group). Five questionnaires, on awareness of environmental control, memory, assessment of intent to act, a satisfaction test, and an Asthma Control Test (ACT), were used to estimate the effects of education. The scores for awareness of environmental control, memory, and intent to act significantly increased after education in both groups, and the scores remained high until 4 weeks after education. Both groups’ ACT scores were consistently high before and 4 weeks after education. Satisfaction scores were very high in the VR group. The increased scores in awareness of environmental control and intent to act indicate that the environmental control education using VR is worthy of attention as an effective educational tool for asthma management. Further developed techniques, including active environmental interventions by participants in VR, could be applied to effective asthma management.
Multiple Monarchy and the Kent Island Controversy: A Scottish Licence, Chesapeake Rivalries and the London Business World
Authors: Wagner Joseph
Published: July 2022

Kent Island, located in Chesapeake Bay, was the subject of fierce debate and competition in the 1630s. Historians typically present the conflict in binary terms relating to its status as either part of one English colony or another; namely, was Kent Island part of the Virginia colony or was it part of the Maryland colony? There was, however, a third interpretation – that Kent Island was not part of an English colony at all but, rather, an independent Scottish trading outpost. This article examines the basis for this alternative interpretation. It was a pivotal issue in the contemporary debate as the initial European occupation of the island was predicated on the rights conveyed in a royal licence granted under the Scottish privy signet. Taking that grant as its starting point, the article analyses the ways in which the 1603 union of the crowns affected colonisation stemming from the British Isles under the Stuart monarchs. The Kent Island controversy is one example of the ‘Scottish complication’ that was present in many colonial endeavours traditionally thought of as solely English. 1
Exposing Atlantic Salmon Post-Smolts to Fluctuating Sublethal Nitrite Concentrations in a Commercial Recirculating Aquaculture System (RAS) May Have Negative Consequences
Authors: Mortensen Heidi S. , Jacobsen Elin , Kolarevic Jelena , Vang Amanda
Published: July 2022

Salmon farmers are interested in extending the time post-smolts are reared in recirculating aquaculture systems (RAS). However, there is a lack of knowledge regarding optimal water quality for post-smolts in RAS, and regarding potential consequences of long term exposure to different toxic compounds, such as nitrite, in the RAS water. To address this issue, we conducted a case study at a Faroese Atlantic salmon farm, that rears large post-smolts in fresh water RAS for 22 months before sea transfer, with no additional chloride salt, a known treatment for nitrite toxicity. The aim was to document the potential effects of long-term exposure of fluctuating sub-lethal nitrite concentrations in fresh water RAS on blood physiology of large post-smolts. The study was conducted over six weeks, at the end of the RAS production cycle. Our case study shows that after ~22 months in RAS with no additional chloride, the fish had accumulated a plasma nitrite concentration 8 to 16 times higher than the ambient water. Our results indicate that the accumulation may have resulted in extracellular hyperkaliemia, since there was a positive correlation between plasma nitrite and potassium levels (p=0.00095), with potassium levels almost twice as high than previously reported for Atlantic salmon. This could indicate that Atlantic salmon health is challenged due to prolonged sub-lethal nitrite exposure in fresh water RAS. Further research related to long-term nitrite exposure in RAS is needed to asses the potential negative impact, in order to optimize welfare and growth performance during production of Atlantic salmon post-smolts.
Surface Roughness and Biocompatibility of Polycaprolactone Bone Scaffolds: An Energy-Density-Guided Parameter Optimization for Selective Laser Sintering
Authors: Han Jian , Li Zehua , Sun Yuxuan , Cheng Fajun , Zhu Lei , Zhang Yaoyao , Zhang Zirui , Wu Jinzhe , Wang Junfeng
Published: July 2022

Three-dimensional porous polycaprolactone (PCL) bone scaffolds prepared by selective laser sintering (SLS) have demonstrated great potential in the repair of non-load-bearing bone defects. The microgeometry and surface roughness of PCL scaffolds during the SLS process may change the biocompatibility and bioactivity of the scaffolds. However, in addition to the widely concerned mechanical properties and structural accuracy of scaffolds, there is still a lack of systematic research on how SLS process parameters affect the surface roughness of PCL scaffolds and the relationship between roughness and biocompatibility of scaffolds. In this study, we use the energy density model (EDM) combined with the thermodynamic properties of PCL powder to calculate the energy density range (Ed1–Ed3) suitable for PCL sintering. Five PCL scaffolds with different laser powers and scanning speeds were prepared; their dimensional accuracy, mechanical strength, and surface properties were comprehensively evaluated, and the bioactivities were compared through the attachment and proliferation of MC3T3-E1 cells on the scaffolds. It was found that the high energy density (Ed3) reduced the shape fidelity related to pore size and porosity, and the dense and smooth surface of the scaffolds showed poor cytocompatibility, while the low energy density (Ed1) resulted in weak mechanical properties, but the rough surface caused by incomplete sintered PCL particles facilitated the cell adhesion and proliferation. Therefore, the surface roughness and related biocompatibility of PCL bone scaffolds should be considered in energy-density-guided SLS parameter optimization.
Flaw Detection in White Porcelain Wine Bottles Based on Improved YOLOv4 Algorithm
Authors: Gong Guoqiang , Huang Jun , Wang Hemin
Published: July 2022

Aiming at the problems of low detection accuracy and slow detection speed in white porcelain wine bottle flaw detection, an improved flaw detection algorithm based on YOLOv4 was proposed. By adding Coordinate Attention to the backbone feature extraction network, the extracting ability of white porcelain bottle flaw features was improved. Deformable convolution is added to locate flaws more accurately, so as to improve the detection accuracy of flaws by the model. Efficient Intersection over Union was used to replace Complete Intersection over Union in YOLOv4 to improve the loss function and improve the model detection speed and accuracy. Experimental results on the surface flaw data set of white porcelain wine bottles show that the proposed algorithm can effectively detect white porcelain wine bottle flaws, the mean Average Precision of the model can reach 92.56%, and the detection speed can reach 37.17 frames/s.
Tumor Cell-Specific and Lipase-Responsive Delivery of Hydrogen Sulfide for Sensitizing Chemotherapy of Pancreatic Cancer
Authors: Tian Libing , Pei Rui , Zhang Xiaojun , Li Kun , Zhong Yuting , Luo Yougen , Zhou Shu-Feng , Chen Lichan
Published: July 2022

The inability of small molecule drugs to diffuse into tumor interstitium is responsible for the relatively low effectiveness of chemotherapy. Herein, a hydrogen sulfide (H2S) gas–involved chemosensitization strategy is proposed for pancreatic cancer treatment by developing a tumor-specific lipase-responsive nanomedicine based on aptamer-conjugated DATS/Dox co-loaded PCL-b-PEO micelle (DA/D@Ms-A). After receptor-mediated endocytosis and subsequent digestion of PCL blocks by intracellular lipase, the nanomedicine releases Dox and DATS, which then react with intracellular glutathione to produce H2S. The cytotoxicity result indicates that H2S can enhance Dox chemotherapy efficiency owing to the synergetic therapeutic effect of Dox and H2S. Moreover, the nanomedicine is featured with well tumor penetration capability benefitting from the targeting ability of aptamers and high in vivo biocompatibility due to the high density of PEO and biodegradable PCL. The nanomedicine capable of synergetic gas-chemotherapy holds great potential for pancreatic cancer treatment.
Digital Twin Aided Sustainability Assessment of Modern Light Rail Infrastructures
Authors: Borjigin Aorigele Orgil , Sresakoolchai Jessada , Kaewunruen Sakdirat , Hammond John
Published: July 2022

This study aims to evaluate the whole life cycle performance of Precast Advanced Track (PCAT) light rail systems in a digital twin environment, which is time-saving, flexible, and highly accurate. Two sustainability aspects of the system are addressed: environmental and economic impacts. In the life cycle assessment (LCA), energy consumption and CO2emissions are calculated, whereas costs at each stage were calculated and converted to present values in the life cycle costing assessment (LCC). Revit is used for assessment. It enables the bill of quantities in the models to provide quantitative data for sustainability assessments. In the PCAT light rail systems, all structures and components have been considered, including subbase, concrete slab, rail fastening, rails, bituminous layer, rubber pad, and grease lubrication. Results exhibit that concrete slabs for street and off-street systems have a minor contribution to minimizing energy consumption, CO2emissions, and costs. Rail fastenings and rails can be recycled, but the energy consumption is relatively enormous. Unrecyclable materials such as bitumen and grout account for a large portion of lifecycle CO2emissions and costs. Surprisingly, these two materials are quite sensitive to parametric change. Accordingly, the digital twin confirms that PCAT concrete slabs demonstrate a good performance throughout the whole life cycle. However, there is still room for improvements, for example, re-designing a concrete slab with less grout while showing good waterproof performance. These structural modifications can be updated on the digital twin to enact positive changes for the sustainable development of light rail systems.
Modification of Aggregate Gradation for Simultaneous Optimization of Evaporation and Permeability of Porous Asphalt Mixtures
Authors: Ghafori fard Zohreh , Khabiri Mohamad Mehdi , Kornél Tamás Almássy
Published: July 2022

Today, with the expaansion of cities and the growth of urbanization, followed by climate change, it is crucial to prevent the occurrence of floods and control it in cities. Porous pavement, including porous asphalt, is known as one of the best methods for urban flood control due to its two properties of evaporation and permeability. The purpose of this study is to modify the gradation of porous asphalt in order to optimize its permeability and evaporation for low-traffic urban passages. For this purpose, permeability, evaporation, and Cantabro tests were performed on samples with different gradations and percentages of bitumen; then, using Design Expert software, the gradation and percentage of optimal bitumen were determined. Finally, the performance of the asphalt gradation and optimal bitumen percentage were evaluated by performing empty space percentage, modified Latman, Marshall, and psychological strength tests and Cantabro tests. The results show that with finer gradation, the permeability, evaporation, and minimum bitumen percentage are reduced by about 55%, 82%, and 60%, respectively. Also, the gradation is medium with 4% bitumen gradation and the percentage of bitumen is optimal, which has a good performance in low-traffic urban passages.
ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype
Authors: Olea-Flores Monserrat , Kan Julia , Carlson Alyssa , Syed Sabriya A. , McCann Cat , Mondal Varsha , Szady Cecily , Ricker Heather M. , McQueen Amy , Navea Juan G. , Caromile Leslie A. , Padilla-Benavides Teresita
Published: July 2022

Zinc (Zn) is an essential trace element that plays a key role in several biological processes, including transcription, signaling, and catalysis. A subcellular network of transporters ensures adequate distribution of Zn to facilitate homeostasis. Among these are a family of importers, the Zrt/Irt-like proteins (ZIP), which consists of 14 members (ZIP1-ZIP14) that mobilize Zn from the extracellular domain and organelles into the cytosol. Expression of these transporters varies among tissues and during developmental stages, and their distribution at various cellular locations is essential for defining the net cellular Zn transport. Normally, the ion is bound to proteins or sequestered in organelles and vesicles. However, though research has focused on Zn internalization in mammalian cells, little is known about Zn mobilization within organelles, including within the nuclei under both normal and pathological conditions. Analyses from stomach and colon tissues isolated from mouse suggested that ZIP11 is the only ZIP transporter localized to the nucleus of mammalian cells, yet no clear cellular role has been attributed to this protein. We hypothesized that ZIP11 is essential to maintaining nuclear Zn homeostasis in mammalian cells. To test this, we utilized HeLa cells, as research in humans correlated elevated expression of ZIP11 with poor prognosis in cervical cancer patients. We stably knocked down ZIP11 in HeLa cancer cells and investigated the effect of Zn dysregulation in vitro. Our data show that ZIP11 knockdown (KD) reduced HeLa cells proliferation due to nuclear accumulation of Zn. RNA-seq analyses revealed that genes related to angiogenesis, apoptosis, mRNA metabolism, and signaling pathways are dysregulated. Although the KD cells undergoing nuclear Zn stress can activate the homeostasis response by MTF1 and MT1, the RNA-seq analyses showed that only ZIP14 (an importer expressed on the plasma membrane and endocytic vesicles) is mildly induced, which may explain the sensitivity to elevated levels of extracellular Zn. Consequently, ZIP11 KD HeLa cells have impaired migration, invasive properties and decreased mitochondrial potential. Furthermore, KD of ZIP11 delayed cell cycle progression and rendered an enhanced senescent state in HeLa cells, pointing to a novel mechanism whereby maintenance of nuclear Zn homeostasis is essential for cancer progression.
The Many Roles of Macrophages in Skeletal Muscle Injury and Repair
Authors: Wang Xingyu , Zhou Lan
Published: July 2022

Skeletal muscle is essential to physical activity and energy metabolism. Maintaining intact functions of skeletal muscle is crucial to health and wellbeing. Evolutionarily, skeletal muscle has developed a remarkable capacity to maintain homeostasis and to regenerate after injury, which indispensably relies on the resident muscle stem cells, satellite cells. Satellite cells are largely quiescent in the homeostatic steady state. They are activated in response to muscle injury. Activated satellite cells proliferate and differentiate into myoblasts. Myoblasts fuse to form myotubes which further grow and differentiate into mature myofibers. This process is tightly regulated by muscle microenvironment that consists of multiple cellular and molecular components, including macrophages. Present in both homeostatic and injured muscles, macrophages contain heterogeneous functional subtypes that play diverse roles in maintaining homeostasis and promoting injury repair. The spatial-temporal presence of different functional subtypes of macrophages and their interactions with myogenic cells are vital to the proper regeneration of skeletal muscle after injury. However, this well-coordinated process is often disrupted in a chronic muscle disease, such as muscular dystrophy, leading to asynchronous activation and differentiation of satellite cells and aberrant muscle regeneration. Understanding the precise cellular and molecular processes regulating interactions between macrophages and myogenic cells is critical to the development of therapeutic manipulation of macrophages to promote injury repair. Here, we review the current knowledge of the many roles played by macrophages in the regulation of myogenic cells in homeostatic, regenerating, and dystrophic skeletal muscles.
Analysis of Clinical Features and Risk Factors in Pregnant Women With Miliary Pulmonary Tuberculosis After In Vitro Fertilization Embryo Transfer
Authors: Dong Siyuan , Zhou Ruoyu , Peng Emin , He Ruoxi
Published: July 2022

Purpose

Miliary pulmonary tuberculosis (TB) among pregnant women after in vitro fertilization embryo transfer (IVF-ET) causes poor outcomes but is rarely reported. This study analyzed the clinical characteristics and risk factors of these patients to provide hints for further studies.

Method

The demographic characteristics, clinical manifestations, radiologic features, treatment, and outcomes of six patients diagnosed from May 2012 to August 2021 in Xiangya Hospital and 69 patients that were reported in English or Chinese literature from January 1980 to August 2021 were retrospectively analyzed. Continuous variables were compared between groups by t-test or Mann–Whitney U test, and categorical variables were compared between groups by chi-square test or Fisher exact test. Univariate and multiple logistic regression analyses were used to determine the predictors of respiratory failure.

Results

A total of 75 patients were included. The average age of patients was about 30 years. All patients had tubal obstruction; 5 of them were diagnosed with pelvic TB before. Thirteen cases had a history of pulmonary or extrapulmonary TB, six out of them without any antituberculosis treatment history. All patients were in their first or second trimester during the onset of symptoms. The average interval between onset of symptoms and radiologic examination was about 21 days. The most common abnormalities on chest computed tomography scan were multiple nodules, pulmonary infiltrate, and consolidation. Merely 10 patients obtained bacteriological diagnosis by Mycobacterium tuberculosis culture or polymerase chain reaction test. The other patients were clinically diagnosed. All the patients received antituberculosis treatment. Although 44% of patients had fatal complications, all cases were cured or improved after antituberculosis treatment. Unfortunately, only eight fetuses survived (10.6%). The most frequent and severe complication was type I respiratory failure (20%). Patients with expectoration, dyspnea, coarse breath sounds, ground-glass opacity, and pulmonary infiltrate or consolidation were more likely to have respiratory failure (P < 0.05). Ground-glass opacity (OR = 48.545, 95% CI = 2.366–995.974, P = 0.012) and pulmonary infiltrate or consolidation (OR = 19.943, 95% CI = 2.159–184.213, P = 0.008) were independent predictors for respiratory failure.

Conclusion

Tube infertility with underscreened or untreated TB is a risk factor for miliary TB during pregnancy after IVF-ET. Ground-glass opacity and pulmonary infiltrate or consolidation are predictors of respiratory failure. We demonstrate risk factors for incidence and complications to supply clues for future intervention and improve patient prognosis.
Convergence of MCR-8.2 and Chromosome-Mediated Resistance to Colistin and Tigecycline in an NDM-5-Producing ST656 Klebsiella pneumoniae Isolate From a Lung Transplant Patient in China
Authors: Zhao Jiankang , Li Ziyao , Zhang Yulin , Liu Xinmeng , Lu Binghuai , Cao Bin
Published: July 2022

We characterized the first NDM-5 and MCR-8.2 co-harboring ST656 Klebsiella pneumoniae clinical isolate, combining with chromosomal gene-mediated resistance to colistin and tigecycline. The K. pneumoniae KP32558 was isolated from the bronchoalveolar lavage fluid from a lung transplant patient. Complete genome sequences were obtained through Illumina HiSeq sequencing and nanopore sequencing. The acquired resistance genes and mutations in chromosome-encoded genes associated with colistin and tigecycline resistance were analyzed. Comparative genomic analysis was conducted between mcr-8.2-carrying plasmids. The K. pneumoniae KP32558 was identified as a pan-drug resistant bacteria, belonging to ST656, and harbored plasmid-encoded blaNDM-5 and mcr-8.2 genes. The blaNDM-5 gene was located on an IncX3 type plasmid. The mcr-8.2 gene was located on a conjugative plasmid pKP32558-2-mcr8, which had a common ancestor with another two mcr-8.2-carrying plasmids pMCR8_020135 and pMCR8_095845. The MIC of KP32558 for colistin was 256 mg/L. The mcr-8.2 gene and mutations in the two-component system, pmrA and crrB, and the regulator mgrB, had a synergistic effect on the high-level colistin resistance. The truncation in the acrR gene, related to tigecycline resistance, was also identified. K. pneumoniae has evolved a variety of complex resistance mechanisms to the last-resort antimicrobials, close surveillance is urgently needed to monitor the prevalence of this clone.
Decision-Making for Managing Climate-Related Risks: Unpacking the Decision Process to Avoid “Trial-and-Error” Responses
Authors: Constable Andrew J. , French Simon , Karoblyte Vita , Viner David
Published: July 2022

We provide an overview of decision support tools and methods that are available for managing climate-related risks and for delivering adaptation and resilience options and solutions. The importance of understanding political, socio-economic and cultural contexts and the decision processes that these tools support is emphasized. No tool or method is universally suited to all circumstances. Some decision processes are structured with formal governance requirements; while others are less so. In all cases, discussions and interactions with stakeholders and other players will have formal and informal aspects. We categorize decision support tools in several broad ways with the aim of helping decision makers and their advisors select tools that are appropriate to their culture, resources and other circumstances. The assessment examines the constraints and methodological assumptions that need be considered.
PERF: Performant, Explicit Radiance Fields
Authors: Rasmuson Sverker , Sintorn Erik , Assarsson Ulf
Published: July 2022

We present a novel way of approaching image-based 3D reconstruction based on radiance fields. The problem of volumetric reconstruction is formulated as a non-linear least-squares problem and solved explicitly without the use of neural networks. This enables the use of solvers with a higher rate of convergence than what is typically used for neural networks, and fewer iterations are required until convergence. The volume is represented using a grid of voxels, with the scene surrounded by a hierarchy of environment maps. This makes it possible to get clean reconstructions of 360° scenes where the foreground and background is separated. A number of synthetic and real scenes from well-known benchmark-suites are successfully reconstructed with quality on par with state-of-the-art methods, but at significantly reduced reconstruction times.