bluuebunny/crossref_metadata_2025 huggingface dataset:
Irrigtion of Gallbladder bed with bupivacaine for post- operative pain relief in laparoscopic cholecystectomy.
Authors: Al-Saad Sabah N.
Published: August 2023

Background: Although pain after laparoscopic cholecystectomy is less intense than after open Cholecystectomy, some patients still experience considerable discomfort, and use of local anaesthetics irrigation is controversial.
Objectives :to evaluate the effect of intraperitoneal and port site instillation of local anaesthetics on pain relief in the first 6 hours postoperatively.
Patient and Method: Forty patients underwent elective laparoscopic cholecystectomy were included in this study and sample was divided into two equal groups. Group A received 20 ml of 0.9% normal saline instilled in the gallbladder bed, while group B received 20 ml of 0.25% bupivacaine instilled in the same region and 10 ml of 0.5% bupivacaine in divided doses at the trocar sites. The evaluation of postoperative pain was done at fixed time interval according to the numerical rating scale,and the request time of analgesics, pain site and vital signs were recorded.
Results: Pain score showed significant difference only at 0h and 1h with p-value <0.05, otherwise there was no significant differences in the following hours. Request for analgesia showed no statistically significant differences.
Conclusions: Intraperitoneal irrigation of bupivacaine is not so effective in decreasing pain after laparoscopic cholecystectomy.
Principles of Design of Clinical Trials for Prevention and Treatment of Alzheimer’s Disease and Aging-Associated Cognitive Decline in the ACH2.0 Perspective: Potential Outcomes, Challenges, and Solutions
Authors: Volloch Vladimir , Rits-Volloch Sophia
Published: August 2023

With the Amyloid Cascade Hypothesis (ACH) largely discredited, the ACH2.0 theory of Alzheimer’s disease (AD) has been recently introduced. Within the framework of the ACH2.0, AD is triggered by amyloid-β protein precursor (AβPP)-derived intraneuronal Aβ ( iAβ) and is driven by iAβ produced in the AβPP-independent pathway and retained intraneuronally. In this paradigm, the depletion of extracellular Aβ or suppression of Aβ production by AβPP proteolysis, the two sources of AβPP-derived iAβ, would be futile in symptomatic AD, due to its reliance on iAβ generated independently of AβPP, but effective in preventing AD and treating Aging-Associated Cognitive Decline (AACD) driven, in the ACH2.0 framework, by AβPP-derived iAβ. The observed effect of lecanemab and donanemab, interpreted in the ACH2.0 perspective, supports this notion and mandates AD-preventive clinical trials. Such trials are currently in progress. They are likely, however, to fail or to yield deceptive results if conducted conventionally. The present study considers concepts of design of clinical trials of lecanemab, donanemab, or any other drug, targeting the influx of AβPP-derived iAβ, in prevention of AD and treatment of AACD. It analyzes possible outcomes and explains why selection of high-risk asymptomatic participants seems reasonable but is not. It argues that outcomes of such AD preventive trials could be grossly misleading, discusses inevitable potential problems, and proposes feasible solutions. It advocates the initial evaluation of this type of drugs in clinical trials for treatment of AACD. Whereas AD protective trials of these drugs are potentially of an impractical length, AACD clinical trials are expected to yield unequivocal results within a relatively short duration. Moreover, success of the latter, in addition to its intrinsic value, would constitute a proof of concept for the former. Furthermore, this study introduces concepts of the active versus passive iAβ depletion, contends that targeted degradation of iAβ is the best therapeutic strategy for both prevention and treatment of AD and AACD, proposes potential iAβ-degrading drugs, and describes their feasible and unambiguous evaluation in clinical trials.
The Ability to Use Contextual Information in Object and Scene Recognition in Patients with Mild Cognitive Impairment
Authors: Wang Yaqi , Yang Kai , Fu Pengrui , Zheng Xiaolei , Yang Hui , Zhou Qingbo , Ma Wen , Wang Ping
Published: August 2023

Background:

The ability to understand and make use of object-scene relationships are critical for object and scene recognition.

Objective:

The current study assessed whether patients with mild cognitive impairment (MCI), possibly in the preclinical phase of Alzheimer’s disease, exhibited impairment in processing contextual information in scene and object recognition.

Methods:

In Experiment 1, subjects viewed images of foreground objects in either semantic consistent or inconsistent scenes under no time pressure, and they verbally reported the names of foreground objects and backgrounds. Experiment 2 replicated Experiment 1, except that subjects were required to name scene first. Experiment 3 examined object and scene recognition accuracy baselines, recognition difficulty, familiarity with objects/scenes, and object-scene consistency judgements.

Results:

There were contextual consistency effects on scene recognition for MCI and healthy subjects, regardless of response sequence. Scenes were recognized more accurately under the consistent condition than the inconsistent condition. Additionally, MCI patients were more susceptible to incongruent contextual information, possibly due to inhibitory deficits or over-dependence on semantic knowledge. However, no significant differences between MCI and healthy subjects were observed in consistency judgement, recognition accuracy, recognition difficulty and familiarity rating, suggesting no significant impairment in object and scene knowledge among MCI subjects.

Conclusions:

The study indicates that MCI patients retain relatively intact contextual processing ability but may exhibit inhibitory deficits or over-reliance on semantic knowledge.
Automatic Detection of Putative Mild Cognitive Impairment from Speech Acoustic Features in Mandarin-Speaking Elders
Authors: Wang Rumi , Kuang Chen , Guo Chengyu , Chen Yong , Li Canyang , Matsumura Yoshihiro , Ishimaru Masashi , Van Pelt Alice J. , Chen Fei
Published: August 2023

Background:

To date, the reliable detection of mild cognitive impairment (MCI) remains a significant challenge for clinicians. Very few studies investigated the sensitivity of acoustic features in detecting Mandarin-speaking elders at risk for MCI, defined as “putative MCI” (pMCI).

Objective:

This study sought to investigate the possibility of using automatically extracted speech acoustic features to detect elderly people with pMCI and reveal the potential acoustic markers of cognitive decline at an early stage.

Methods:

Forty-one older adults with pMCI and 41 healthy elderly controls completed four reading tasks (syllable utterance, tongue twister, diadochokinesis, and short sentence reading), from which acoustic features were extracted automatically to train machine learning classifiers. Correlation analysis was employed to evaluate the relationship between classifier predictions and participants’ cognitive ability measured by Mini-Mental State Examination 2.

Results:

Classification results revealed that some temporal features (e.g., speech rate, utterance duration, and the number of silent pauses), spectral features (e.g., variability of F1 and F2), and energy features (e.g., SD of peak intensity and SD of intensity range) were effective predictors of pMCI. The best classification result was achieved in the Random Forest classifier (accuracy = 0.81, AUC = 0.81). Correlation analysis uncovered a strong negative correlation between participants’ cognitive test scores and the probability estimates of pMCI in the Random Forest classifier, and a modest negative correlation in the Support Vector Machine classifier.

Conclusions:

The automatic acoustic analysis of speech could provide a promising non-invasive way to assess and monitor the early cognitive decline in Mandarin-speaking elders.
Common Molecular Signatures Between Coronavirus Infection and Alzheimer’s Disease Reveal Targets for Drug Development
Authors: Abyadeh Morteza , Yadav Vijay K. , Kaya Alaattin
Published: August 2023

Background:

Cognitive decline is a common consequence of COVID-19, and studies suggest a link between COVID-19 and Alzheimer’s disease (AD). However, the molecular mechanisms underlying this association remain unclear.

Objective:

To understand the potential molecular mechanisms underlying the association between COVID-19 and AD development, and identify the potential genetic targets for pharmaceutical approaches to reduce the risk or delay the development of COVID-19-related neurological pathologies.

Methods:

We analyzed transcriptome datasets of 638 brain samples using a novel Robust Rank Aggregation method, followed by functional enrichment, protein-protein, hub genes, gene-miRNA, and gene-transcription factor (TF) interaction analyses to identify molecular markers altered in AD and COVID-19 infected brains.

Results:

Our analyses of frontal cortex from COVID-19 and AD patients identified commonly altered genes, miRNAs and TFs. Functional enrichment and hub gene analysis of these molecular changes revealed commonly altered pathways, including downregulation of the cyclic adenosine monophosphate (cAMP) signaling and taurine and hypotaurine metabolism, alongside upregulation of neuroinflammatory pathways. Furthermore, gene-miRNA and gene-TF network analyses provided potential up- and downstream regulators of identified pathways.

Conclusion:

We found that downregulation of cAMP signaling pathway, taurine metabolisms, and upregulation of neuroinflammatory related pathways are commonly altered in AD and COVID-19 pathogenesis, and may make COVID-19 patients more susceptible to cognitive decline and AD. We also identified genetic targets, regulating these pathways that can be targeted pharmaceutically to reduce the risk or delay the development of COVID-19-related neurological pathologies and AD.
Deep recommendation system based on knowledge graph and review text
Authors: Liu Ning , Zhao Jianhua
Published: August 2023

With the explosive increase of information, recommendation system is applied in a variety of areas. However, the performance of recommendation system is limited due to issues such as data sparsity, cold starts and poor semantic understanding. In order to make full use of external information to assist recommendation, deeply mine the semantic information of review text and further improve the performance of recommendation system, a deep recommendation system based on knowledge graph and review text (Drs-kgrt) is proposed in this paper. In Drs-kgrt, knowledge graph, review text and the social records between users are used as auxiliary information to improve recommendation performance. Firstly, the review text is divided into user review text and item review text. BERT (Bidirectional Encoder Representation from Transformers) is used to accurately understand semantic information in user review text and the social records between users. The trust relationship between users and user preferences are fully mined to form user feature vectors. Secondly, BERT and knowledge graph entity recognition link technology are combined to extract item attribute feature entities and their associated entities. The fine-grained features of the items are analyzed to form item feature vectors. Thirdly, based on the scoring matrix, latent vectors of users and items are obtained by matrix decomposition. The deep features of users and items are generated based on user feature vectors, item feature vectors, latent vectors of users and items, the deep recommendation system is established to predict user scores for items. Finally, experiments are conducted on the Douban dataset and Amazon Movie Review dataset, the results show that the proposed algorithm can achieve better performance compared with other benchmark recommendation algorithms.
Detecting offensive language using Chaotic Ant Lion optimization-based Ghost net in social media
Authors: Adaikkan Kalaivani , Thenmozhi Durairaj
Published: August 2023

Social media has become one of the most popular medium of communication and the post may be predominantly unstructured, informal, and frequently misspelled. It has become increasingly common for users to use abusive language in their comments. Detecting offensive language on social media platforms and the presence of such language on the Internet has become a major challenge for modern society. To overcome this challenge, Offensive Language Classification based on the Chaotic Antlion optimization algorithm has been proposed. Initially, the dataset is pre-processed using NLP languages for removing irrelevant data. Consequently, statistical, synthetic, and lexicon features are extracted using various feature extraction techniques. A Chaotic Antlion Optimization Algorithm is used to select the most relevant features during the feature selection phase. After selecting the features, a Ghost network classifies the input data into four classes namely offensive, non-offensive, swear, and offensive but not offensive. The proposed method was evaluated based on a number of variables, including precision, accuracy, specificity, recall, and F-measure. The best classification accuracy is achieved by the suggested method, which is 99.27% for the SOLID dataset and 98.99% for the OLID dataset. The suggested method outperforms the DCNN, Simple Logistics, and CNN methods in terms of overall accuracy by 4.99%, 8.72%, and 10.4%, respectively.
Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson’s Disease as a Multi-System Process
Authors: Videlock Elizabeth J. , Hatami Asa , Zhu Chunni , Kawaguchi Riki , Chen Han , Khan Tasnin , Yehya Ashwaq Hamid Salem , Stiles Linsey , Joshi Swapna , Hoffman Jill M. , Law Ka Man , Rankin Carl Robert , Chang Lin , Maidment Nigel T. , John Varghese , Geschwind Daniel H. , Pothoulakis Charalabos
Published: August 2023

Background:

Evidence supports a role for the gut-brain axis in Parkinson’s disease (PD). Mice overexpressing human wild type α– synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation in PD. Identifying molecular changes in the gut could provide both biomarkers for early diagnosis and gut-targeted therapies to prevent progression.

Objective:

To identify early molecular changes in the gut-brain axis in Thy1-haSyn mice through gene expression profiling.

Methods:

Gene expression profiling was performed on gut (colon) and brain (striatal) tissue from Thy1-haSyn and wild-type (WT) mice aged 1 and 3 months using 3′ RNA sequencing. Analysis included differential expression, gene set enrichment and weighted gene co-expression network analysis (WGCNA).

Results:

At one month, differential expression (Thy1-haSyn vs. WT) of mitochondrial genes and pathways related to PD was discordant between gut and brain, with negative enrichment in brain (enriched in WT) but positive enrichment in gut. Linear regression of WGCNA modules showed partial independence of gut and brain gene expression changes. Thy1-haSyn-associated WGCNA modules in the gut were enriched for PD risk genes and PD-relevant pathways including inflammation, autophagy, and oxidative stress. Changes in gene expression were modest at 3 months.

Conclusions:

Overexpression of haSyn acutely disrupts gene expression in the colon. While changes in colon gene expression are highly related to known PD-relevant mechanisms, they are distinct from brain changes, and in some cases, opposite in direction. These findings are in line with the emerging view of PD as a multi-system disease.
Relationship between anxiety and concussion symptoms among adolescents enrolled in a randomized controlled trial of aerobic exercise
Authors: D’Alonzo Bernadette A. , Wiebe Douglas J. , Master Christina L. , Castellana Matthew C. , Willer Barry S. , Leddy John J.
Published: August 2023

BACKGROUND: Affective symptoms, specifically, anxiety, are often overlooked after sport-related concussion (SRC), and may contribute to prolonged recovery. OBJECTIVE: To examine the impact of anxiety during clinical recovery among adolescents (13–18y) enrolled in a randomized trial of aerobic exercise for SRC. METHODS: Patients at three sites were randomized into aerobic exercise or stretching arms, and enrolled in the 4-week intervention. The relationship between PROMIS Anxiety score at initial visit and time to symptom resolution was evaluated with survival analysis. The relationship between weekly PROMIS Anxiety score and Post-concussion Symptom Inventory (PCSI) score was evaluated with Linear Mixed Models. Analyses adjusted for study arm and baseline covariates. RESULTS: Among 54 adolescents (median age = 15.8y, initial visit PCSI score = 32, pre-injury PROMIS Anxiety score = 2), median time to symptom resolution was 10 days (25th-75th percentiles: 6-24) in the Low-PROMIS Anxiety group and 12 days (25th-75th percentiles: 5-21) in the High-PROMIS Anxiety group (p = 0.62). Each additional unit of PROMIS Anxiety score corresponded to a 1.52-unit higher PCSI total score (p <  0.01). Neither effect varied by aerobic exercise/stretching group. CONCLUSION: Higher initial PROMIS Anxiety score was not significantly associated with delayed symptom resolution. However, over time, PROMIS Anxiety score was significantly associated with elevated PCSI score, regardless of exercise/stretching group.
What is in your cookie box? Explaining ingredients of web cookies with knowledge graphs
Authors: Bushati Geni , Rasmusen Sven Carsten , Kurteva Anelia , Vats Anurag , Nako Petraq , Fensel Anna
Published: August 2023

The General Data Protection Regulation (GDPR) has imposed strict requirements for data sharing, one of which is informed consent. A common way to request consent online is via cookies. However, commonly, users accept online cookies being unaware of the meaning of the given consent and the following implications. Once consent is given, the cookie “disappears”, and one forgets that consent was given in the first place. Retrieving cookies and consent logs becomes challenging, as most information is stored in the specific Internet browser’s logs. To make users aware of the data sharing implied by cookie consent and to support transparency and traceability within systems, we present a knowledge graph (KG) based tool for personalised cookie consent information visualisation. The KG is based on the OntoCookie ontology, which models cookies in a machine-readable format and supports data interpretability across domains. Evaluation results confirm that the users’ comprehension of the data shared through cookies is vague and insufficient. Furthermore, our work has resulted in an increase of 47.5% in the users’ willingness to be cautious when viewing cookie banners before giving consent. These and other evaluation results confirm that our cookie data visualisation approach and tool help to increase users’ awareness of cookies and data sharing.
Bridging the gap: Hospital to workplace
Authors: Matheson Leonard N.
Published: August 2023

BACKGROUND: Work-oriented neurorehabilitation to return to competitive employment after a serious neurologic illness or injury is an interdisciplinary process that begins as soon as pathology has stabilized. OBJECTIVE: This bimonthly column provides narratives of anonymized clients in situations that challenge their return-to-work. Each case study is designed for postgraduate education about tools and methods that are appropriate to consider in similar situations. METHODS: Through case studies of adults attempting to return to safe and dependable competitive employment, real-world issues are explored that occur at the interface between the client and their employer. RESULTS: The current case describes Structured Task Self Appraisal (STSA), a forensic rehabilitation method to collect self-report baseline information concerning the client’s job-relevant functional limitations. STSA guides return-to-work rehabilitation services. CONCLUSION: Information concerning the core tasks and important abilities of the client’s target occupation that are immediately available in O*NET can be analyzed in a structured manner to provide the workplace context for rehabilitation.
Instrumentação de espectroscopia no infravermelho próximo para previsão bromatológica do farelo de trigo
Authors:   Embrapa Caprinos e Ovinos, Santos Sueli Freitas dos , Bomfim Marco Aurélio Delmondes ,   Embrapa Caprinos e Ovinos
Published: August 2023

Wheat bran samples were collected during 12 months in the Brazilian states (Ceará, Paraíba and Rio Grande do Sul) and sent to Embrapa Caprinos e Ovinos, for analytical procedures. The samples received (300 copies) were destined to a first spectral reading in an NIR Perten instrument. Within this reading, 107 samples were selected, classified as (in natura samples read in NIR Perten). Then, the reference analyzes were carried out simultaneously with a second reading again in a NIR Perten instrument, classified as (dry and ground samples read in NIR Perten) and a third reading, in a NIR FOSS instrument, classified as (dry and ground samples read in NIR FOSS). Models for crude protein (CP) and in vitro digestibility of dry matter (IVDMD) and organic matter (IVOMD) were developed for both instruments with the three spectral readings performed. NIR instrumentation, associated with chemometric techniques, accurately predicted crude protein, in vitro dry matter digestibility and in vitro organic matter digestibility of wheat bran.
Hasil Variasi Media Quenching Terhadap Kekuatan Tarik Baja S45C
Authors: Sulistyono Sulistyono , Nurwansyah M Hasyim , Asrori Asrori
Published: August 2023

Dalam penelitian ini, baja S45C akan diuji dan dibandingkan nilai kekuatan tarik yang dimiliki sebelum dan setelah diberikan perlakuan panas Quench Hardening. Suhu pemanasan yang digunakan dalam proses perlakuan panas ialah 850 ℃, dengan holding time yaitu 30 menit. Media quenching yang digunakan yaitu “Es Batu Ditambah Air”, “Larutan NaCl 3,45%”, dan “Oli SAE 10W-30”. Hasil dari pengujian tarik menunjukkan bahwa media quenching “Es Batu ditambah Air” dan media quenching “Larutan NaCl 3,45%” menghasilkan rata-rata nilai kekuatan tarik 156,27 MPa dan 228,55 MPa, sementara pada raw material dan media quenching “Oli SAE 10W-30” menghasilkan rata-rata nilai kekuatan tarik 707,03 MPa dan 1.116,30 MPa.
The Effect of Shot Peening Hardening Treatment on Pressure Variation on Mechanical Properties and Microstructure of S45C Steel
Authors: Sakuri Sakuri , Agung M. , Prabowo Nugrah Rekto , Sutisna Utis , Al Hakim Reza Azizul Nasa
Published: August 2023

The purpose of the study was to determine the mechanical properties and microstructure of S45C steel with automatic shot peening treatment. S45C steel is classified as medium steel with a carbon content of 0.51%. Variations of shot peening treatment with varying pressures of 5 bar, 6 bar, and 7 bar. Steel ball shooting uses a size of 0.8 mm, a distance of 100 mm, and a shooting angle of 90o. Hardness test using Vickers and microstructure observation using a microscope. The results of the average hardness test at a pressure of 5 bar are 193.3 VHN, at a pressure of 6 bar with a hardness of 227.2 VHN, and 7 bar with a hardness of 250 VHN. So it can be concluded that the higher the pressure used, the higher the level of hardness obtained. The results of the microstructute photo shown that the higher the pressure released, the more a structure with more martensite phases will be obtained, this has a direct relationship with the hardness of S45C steel.
Analisa Pengaruh Waktu Inisiasi Pembakaran Terhadap Karakteristik Arang Tempurung Kelapa Menggunakan Alat Tungku Minim Asap dengan Sistem Konsentrasi Asap
Authors: Suharlan Didy , Dharma Budi , Suherman Suherman , Harahap Muchsin
Published: August 2023

Proses pembuatan arang secara tradisional menghasilkan rendemen yang rendah dan kandungan air yang tinggi sehingga harus dijemur dibawah panas matahari. Sebagian besar proses pembuatan arang dengan cara tradisional dilakukan dengan cara membakar secara langsung tempurung kelapa dan untuk memadamkannya menggunakan air. Tujuan dari penelitian ini adalah mendesain drum kiln dan mensimulasikan aliran panas dari dapur pemanas menggunakan software SOLIDWORKS. Pada penelitian ini juga dipelajari pengaruh waktu inisasi pembakaran tempurung kelapa pada temperatur pemanasan 450 oC terhadap rendemen arang tempurung kelapa dari waktu 2-5 jam pembakaran dan membandingkan dengan cara konvensional. Hasil penelitian menunjukkan, waktu inisiasi optimum diperoleh pada 2 jam proses yang menghasilkan rendemen sebesar 60%. Selanjutnya, proses pembakaran konvensional hanya mengasilkan rendemen 30% dengan waktu proses lebih lama yaitu 7 jam. Peningkatan lama  pemanasan menurunkan kadar air dan kadar abu pada arang. Proses pembakaran dengan tungku arang minim asap dengan sistem konsentrasi asap lebih baik dibandingkan pembakaran konvensional. Kualitas arang yang dihasilkan dari pembakaran tungku minim asap dengan sistem konsentrasi asap lebih baik dibanding dengan cara tradisional. Hasil simulasi aliran panas dengan SOLIDWORKS diperoleh karakteristik aliran panas turbulen pada bagian dalam drum kiln dan bagian atas penutup luar.
Improving legal provisions of the member’s stake in a limited liability company under vietnamese law on enterprises 2020
Authors:   Faculty of Law, Van Lang University, Vietnam, Trần Thiên Trang , Mai Hoàng Phước ,   University of Economics and Law, VNUHCM, Vietnam
Published: August 2023

Law on Enterprises 2020 has offered many favorable opportunities for investors, created flexibility in business for increased enterprise freedom, and contributed to eliminating the limitations of Law on Enterprise 2014. For the first time in Vietnamese Law on Enterprises, a multi-member limited liability company is allowed to issue shares to convert into a joint-stock company. In addition to the openness in multi-member limited liability companies’ capital mobilization, the 2020 also provides clearer and stricter regulations on corporate governance enhancing the level of protection for investors through regulations on capital transfer conditions and stakes handling. However, there are still some restrictions in the provisions of governing the stakes ins multi-member limited liability companies. This article identifies and analyzes limitations in regulations related to the member’s stake in a multi-member limited liability company via three cases: i) Redemption of the member’s stake in a multi-member limited liability company; ii) Handling the member’s stake in the event of conversion to a joint-stock company; iii) Transfer of the member’s stake in some particular cases. On that basis, the article proposes solutions to improve the effectiveness of the Vietnamese Law on Enterprises.
The impact of motivations, shopping orientations on fashion purchase intention in shopping centres: The moderating role of comsumption knowledge
Authors:   Univeristy of Economics and Law, VNUHCM, Vietnam, Huỳnh Thanh Tú , Nguyen Duy Phong ,   Department of Industry and Trade of Long An, Tan An city, Long An province, Vietnam
Published: August 2023

This research was carried out in the context of fashion shopping at shopping centers in Vietnam, in which determining shopping orientations remains discrete, inconsistent and yet unable to meet the current rapidly changing consumer demands. Furthermore, topics including which motivations forming orientations and the impact of such shopping orientations on purchase intention are still under debate within the scientific community. Therefore, this paper aims to establish a theoretical framework to depict the relationship between motivations, shopping orientations and purchase intention as well as to evaluate moderating role of consumption knowledge. Deduction method was applied with research process divided into two stages: qualitative and quantitative research. Research results revealed that three shopping motivations did not directly impact on purchase intention but indirectly through the mediators (ie. shopping orientations), and the interaction effect of consumption knowledge with convenience shopping orientations on purchase intention was statistically significant. Several practical implications for fashion retailers are also recommended in this study.
Implementation of artificial intelligence in the nursing profession: Barriers & facilitators
Authors:   Department of Medical-Surgical, Amol Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran, Gholampour Mohammad Hashem , Zare-Kaseb Akbar ,   Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Arbabi Zahra ,   Department of Medical-Surgical Nursing, Kashan University of Medical Sciences, Kashan, Iran, Ghazanfari Mohammad Javad ,   Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Published: August 2023

Nurses make up the largest group of healthcare professionals worldwide and are therefore more likely to be heavily exposed to artificial intelligence (AI) technologies due to their significant workforce [1, 2]. The utilization of AI techniques in nursing is being implemented to improve decision-making processes, advance patient care, and optimize the delivery of services [3-5]. Considering the wide use of AI in this profession, there are several barriers and challenges in this path, which can be facilitated by removing these barriers. Some of these barriers are changing the intrinsic nature of healthcare delivery, ethical risks, the validity of evidence, the fairness of outcomes, and the traceability of harm caused by algorithmic activity [6]. Nursing technologies currently in use gather and utilize healthcare data that can anticipate future events that have the potential to obstruct the delivery of care [7]. The precise and safe development and deployment of AI in mental health nursing requires careful consideration of the nuances of clinical complexities, while also ensuring adherence to ethical nursing principles [8]. AI can harm the patient-nurse communication. However, AI has potential benefits to serve patients and improve care delivery and patients’ outcomes [9]. Robot nurses and AI applications have been shown to alleviate the burden on nurses, improve the quality of patient care, and reduce the potential for medical errors and malpractice [10]. In general, it is recommended that nursing policy makers and managers pay special attention to the implementation of AI to improve the quality of nursing care. Also, it is suggested that researchers in the nursing profession design well-designed studies to evaluate the implications of implementing AI to improve the quality of nursing care.
The use of phytobiotics in fish feeding as an alternative to antibacterial and probiotic preparations (review)
Authors: Miroshnikova E. P. , Arinzhanov A. E. , Kilyakova Yu. V. , Sizentsov A. N.
Published: August 2023

Relevance. The use of antibacterial drugs as feed additives for many years has made it possible to reduce the risk of developing infectious pathologies and, as a result, increased the productivity of the industry, in addition to obvious advantages, the constant use of antibiotics develops bacterial resistance, negatively affects representatives of the normoflora of biocenoses and has an accumulating effect in aquaculture. One of the possible ways to increase productivity is the use of probiotic strains with pronounced antagonistic characteristics against pathogenic microorganisms. It should be noted that for optimal fish growth, a high level of species-specificity of the structural microbiome is necessary, which ultimately cannot guarantee the effectiveness of the use of commercial probiotic drugs in fish feeding diets.

Results. The presented scientific data on the use of phytobiotics indicate not only a pronounced effect stimulating the growth of fish, but also a high antioxidant and immunostimulating effect. Separately, it is worth noting the high level of effectiveness of the tested plants against pathogenic strains of A. hydrophila microorganisms (purslane leaf powder; dogwood fruit extract; a combination of essential oils of thyme, red thyme and rosemary pepper; food nanoparticles of cinnamon, a combination of extracts of coriander, mallow, oak acorn; pandanus roofing extract), A. veronii (apricot seed powder), L. monocytogenes (basil clove leaf extract), S. agalactiae (Belgian quince fruit extract). Hypothetically, this mechanism can be explained not only by the activation of indicators of nonspecific immunity, but also by the influence of the majority of plants tested in experiments with the anti Quorum Sensing effect. This review is aimed at describing the global trend in the use of phytobiotics in fish feeding.
The effect of feed additives on the hematological and productive qualities of young cattle
Authors: Fatkullin R. R. , Belookov A. A. , Ermolova E. M. , Rebezov M. B. , Maksimova R. A.
Published: August 2023

Relevance. The development of cattle breeding and the production of high-quality beef in Russia is currently one of the important tasks. This paper presents the results of studies on the effect of a feed additive based on colostrum oil, protein hydrolysate and vitamins on the morphological and biochemical parameters of the blood of young animals.

Methods. The diet of animals of the experimental group included a feed additive, which includes colostrum oil, protein hydrolysate and vitamins. The feed additive was introduced into the daily diet at a dose of 100 g per head per day. It has been established that the introduction of a feed additive into the diet of young animals has a positive effect on the morphological and biochemical composition of blood, contributes to increasing the productivity of young cattle.

Results. The results of scientific and economic experience have shown that the use of feed additives in the feeding of young cattle is an effective method of reducing productivity losses during cultivation and contributes to improving the productive qualities of farm animals.
УДОСКОНАЛЕННЯ ЗБУТОВОЇ ПОЛІТИКИ ПІДПРИЄМСТВ НА ОСНОВІ ВЗАЄМОДІЇ МАРКЕТИНГУ ТА ЛОГІСТИКИ
Authors: Боровик Т. В. , Майборода О. В. , Решетнікова О. В.
Published: August 2023

Розглянуто існуючі визначення поняття «збутова політика підприємства» та наведено власне бачення даного терміну. Досліджено основні аспекти збутової політики підприємств. Узагальнено теоретико-методичні та обґрунтовано науково-практичні засади ефективного використання маркетингу та логістики для удосконалення збутової політики підприємств. Проведено порівняльний аналіз маркетингових та логістичних задач організації збуту продукції підприємства. Наведено основні задачі поєднання маркетингу та логістики в системі збуту продукції, реалізація яких сприяє досягненню головної цілі збутової політики підприємства – забезпечення доставки продукції споживачам з високим рівнем сервісу та оптимальними затратами. Представлено схему процесу збуту продукції на основі інтеграції маркетингу та логістики.
FORMATION OF EDUCATIONAL SYSTEMS WITH ADAPTIVE MANAGEMENT
Authors:   Odessa Polytechnic National University, Zakharchenko Vitaliy , Merkulov Mykola ,   Izmail State Humarity University, Fomina Nataliia ,   Odessa Polytechnic National University
Published: August 2023

Modernity gives us a different understanding of education and, accordingly, they evaluate its role in social development in different ways. The quality of higher education in the study is considered from different positions – the quality of educational activity, the quality of the educational process, the quality of the specialist. More attention is paid to educational activities. The effectiveness of educational activity is determined by the ratio of effects in value terms to the costs of measures that lead to a change in the quality of educational activity. Several models of quality management of educational activities are considered. Preference is given to European standards and recommendations of the internal quality assurance of education in universities, where a significant role is given to the policy and procedures of quality assurance of monitoring and periodic evaluation of programs and qualifications, assessment of students' knowledge level, guarantee of the competence of teaching staff, educational resources, information system. It is proposed to implement the concept of adaptive management of educational activity as a targeted, preventive change in the external environment, influence on the factors determining the quality of educational activity within the limits of state and European standards. The basic classification feature of the construction of the management system, which determines the appearance of the system itself and its potential capabilities. The method of organization of the management circuit is chosen. Adaptive systems are aimed at combating uncertainty by obtaining additional information about the state of the object and its interaction with the environment in the process of management with the corresponding restructuring of the system structure and changing its parameters when operating conditions deviate from a priori known ones.
SUBSTANTIATION OF THE NEED FOR FORMATION OF THE STATE INNOVATIVE SYSTEM IN THE FIELD OF MARINE ACTIVITIES
Authors:   Admiral Makarov National University of Shipbuilding, Korniienko Oksana
Published: August 2023

The article substantiates that the essence of competitiveness at the enterprises of the maritime complex lies in the strengthening of the process of global division of labor due to the interdependence of the macroregions of the globe, as well as in the structural disproportions of their development and the unevenness of the spatial distribution of the resource base in combination with environmental and other limitations. The protectionist steps taken by the maritime states with the aim of increasing the competitiveness of all types of maritime activities are analyzed. The main vectors of activities of international programs for achieving sustainable development, which provide for the prevention and reduction of the consequences of natural disasters and anthropogenic disasters in the World Ocean, the study of the role of the World Ocean, assessment, forecasting, mitigation and adaptation to variations and climate change, improvement of the management system of biological , mineral and energy resources of the World Ocean, improvement of management and protection of marine ecosystems. The article outlines that protectionist measures, such as cargo preferences and reservation of a large part of the cargo base for national shipowners, is a common international practice, characteristic of both leading maritime states and intensively developing coastal countries. It has been proven that the general increase in the need for mineral raw materials and the ever-increasing degree of depletion of its reserves on the continental part of the Planet led to the intensification of search and exploration work for highly liquid types of minerals, primarily oil and gas, on the continental shelf and oceanic slopes. In the article, it is determined that in the interests of increasing their own competitiveness, developed maritime states are conducting a course on anticipatory development of information support for maritime activities using modern means of navigation and communication. It has been analyzed that in our country there is an increasing disconnection of information support systems for maritime activities of the state, an insufficient level of their connection with international and global information systems and networks.
THE INFLUENCE MONETARY POLICY ON THE INVESTMENT CLIMATE IN UKRAINE
Authors:   Sumy National Agrarian University, Rybina Larysa , Kondratenko Sophia ,   Sumy National Agrarian University
Published: August 2023

The post-war reconstruction of Ukraine requires the activation of investment activity and improvement of investment attractiveness, which form the investment climate in the country. One of the problematic issues of limiting investment activity in Ukraine is the availability of funds to finance investments. The purpose of the article is to highlight individual results of the study aimed at improving the theoretical and methodological foundations for assessing the impact of monetary policy on the formation of a favourable investment climate. Analysis of the dynamics of capital investments in Ukraine over the past 7 years shows a positive trend of their growth. But the main source of investment financing is the company's own funds, and bank loans are practically not used in investments. The inflation targeting regime of the National Bank of Ukraine monetary policy introduced at the end of 2022 is aimed at curbing inflation within 5%, and this is possible thanks to an increase in the discount rate (25%). But inflation control has a double effect: it restrains inflation and production (slows down aggregate demand). It should also be taken into account that economic indicators change with a delay under the influence of monetary policy. This is due to the fact that deposit and lending rates, determined directly by market participants, react to changes in the discount rate not immediately, but with a certain lag. The monetary policy has a direct influence on the supply of money in the money market. The choice of monetary policy regimes is mediated through the interest and credit channels of the transmission mechanism of monetary policy, which affect investment activity in the country, but with a certain lag, the duration of which is determined by subjective factors. The analysis of capital investments for the period 2015–2021 and the main indicators of monetary policy showed the need for the simultaneous use of state instruments for the regulation of investment activities in the country. The development of systemic state policy measures and their combination with monetary policy instruments should be aimed at establishing confidence and stimulating capital investments to overcome the investment crisis.
УДОСКОНАЛЕННЯ МЕХАНІЗМУ АНАЛІЗУ ТА ПЛАНУВАННЯ МАРКЕТИНГОВОЇ ДІЯЛЬНОСТІ ПІДПРИЄМСТВ АПК В СФЕРІ ЗОВНІШНЬОЕКОНОМІЧНОЇ ДІЯЛЬНОСТІ
Authors: Мазур К.В. , Гонтарук Я.В.
Published: August 2023

В статті досліджено умови функціонування підприємств агропромислового сектору в сфері маркетингу. Досліджено основні напрями забезпечення подальшого розвитку даного сектору економіки. Констатовано, що організація маркетингової діяльності в АПК у сфері ЗЕД покликана вирішувати такі завдання: максимальне задоволення потреб покупців на світових ринках в продуктах харчування за кількістю, якістю і споживчими властивостями; здійснення міжрегіонального обміну; вихід на внутрішній і зовнішній ринки. Визначено, що виходячи із сьогоднішніх економічних та соціальних реалій, найбільш раціональним є створення служби маркетингу саме за ринково-функціональною ознакою, коли спеціалісти з маркетингу керують різними функціями міжнародної маркетингової діяльності. Розроблено схему організації служби експортного маркетингу на підприємствах АПК за ринково-функціональною ознакою. Запропоновано модель удосконалення механізму маркетингової діяльності підприємств агропромислового сектору.
ОБЛІКОВО-АНАЛІТИЧНЕ ЗАБЕЗПЕЧЕННЯ ФІНАНСОВОЇ БЕЗПЕКИ АГРАРНИХ ПІДПРИЄМСТВ
Authors: Бірченко Н.О. , Руденко С.В. , Ряснянська А.М.
Published: August 2023

У статті досліджено основні аспекти обліково-аналітичного забезпечення фінансової безпеки аграрних підприємств. Виявлено, що фінансова безпека як складова економічної безпеки передбачає виокремлення фінансового аспекту, який представляє собою комплекс заходів, щодо запобігання ймовірному збитку від дії негативних факторів за різними фінансово-економічними показниками підприємства. Запропоновано відобразити систему обліково-аналітичного забезпечення фінансової безпеки аграрних підприємств у вигляді облікової складової, яка включає фінансовий, управлінський та податковий облік, аналітичної складової, до якої включено фінансовий, економічний та стратегічний аналіз, а також контролюючої складової, яка містить зовнішній, внутрішній та стратегічний контроль. Наголошено на тому, що запропонована система обліково-аналітичного забезпечення функціонує на основі облікової, необлікової, нормативно-правової та аналітичної інформації. Виділено чотири етапи обліково-аналітичного забезпечення фінансової безпеки аграрних підприємств.
МОДЕРНІЗАЦІЯ ФІСКАЛЬНОГО МЕНЕДЖМЕНТУ В УМОВАХ ЦИФРОВІЗАЦІЇ
Authors: Гавриленко Н.В. , Грищенко О.В. , Козіцька Н.О.
Published: August 2023

В статті зазначено, що цифрове фіскальне середовище для платника податків - фізичної особи – це, насамперед, його особистий кабінет, а доступ до нього можливий як в межах офіційного сайту фіскальних органів, так і з мобільного додатку. Доведено, що результати ухвалених фіскальними органами заходів щодо розширення цифрового середовища та підвищення ефективності податкового контролю, в кінцевому підсумку проявляються в зростанні податкових надходжень в бюджетну систему України. Запропонована модель, в основі якої покладено цифрову платформу, відображає всі ті основні елементи, які сприятимуть пом'якшенню наявних і можливих перешкод у взаємодії фіскальних органів і платників податків. Перший найважливіший момент полягає в тому, що при вирішенні такої задачі, як розшифрування цифрового фіскального середовища у фіскальних органів повинні залишатися і традиційні канали взаємодії з платниками податків.
ОПТИМІЗАЦІЯ ФУНКЦІОНУВАННЯ МАЛИХ СІЛЬСЬКОГОСПОДАРСЬКИХ ПІДПРИЄМСТВ У КОНТЕКСТІ СПІВПРАЦІ З РЕГІОНАЛЬНИМИ ДОРАДЧИМИ СЛУЖБАМИ
Authors: Савченко В.М. , Кононенко Л.В.
Published: August 2023

Стаття присвячена дослідженню сучасного стану та науковому обґрунтування рекомендацій з удосконалення інформаційного забезпечення функціонування малих сільськогосподарських підприємств у контексті співпраці з регіональними дорадчими службами в умовах цифровізації. Методика дослідження ґрунтується як на загальнонаукових так і спеціальних методах дослідження, а саме: логічного узагальнення, системному, індукції, дедукції, аналізу, синтезу, анкетування, класифікації, групування тощо. У ході дослідження встановлено, що оптимізація функціонування малих аграрних підприємств значною мірою обумовлена можливістю отримання та якістю дорадчих послуг, організація яких ґрунтується на цифровізації. Доведено, що ефективна робота дорадчих служб, яка спрямована на забезпечення розвитку малих аграрних підприємств, можлива за умови використання висококваліфікованих кадрів дорадчої служби, науковців та переваг цифровізації. Обґрунтовано доцільність адаптації дорадчої служби до вимог цифрового суспільства шляхом створення цифрової платформи електронного дорадництва, використання якої є доцільним поєднати із потенціалом висококваліфікованих дорадників.
КОНТРОЛІНГ СТРАТЕГІЧНОГО УПРАВЛІННЯ НА ПІДПРИЄМСТВАХ В УМОВАХ ЦИФРОВОЇ ЕКОНОМІКИ
Authors: Сазонова С.В. , Новиков Д.М.
Published: August 2023

У період становлення та розвитку цифрової економіки одним з найбільш важливих аспектів стратегічного управління підприємством є контролінг. У статті розглянуті поняття, цілі, задачі та функції контролінгу на сучасних високотехнологічних підприємствах, його сутність та роль у системі стратегічного управління підприємством. Відображена роль контролінгу, який в умовах цифровізації та діджиталізації виступає у ролі агрегуючого інструменту стратегічного управління та являє собою основу управлінської діяльності сучасних підприємств, які є базисом для розвитку цифрової економіки. Визначено ключові тенденції стратегічного управління підприємствами в умовах цифрової економіки та різких змін зовнішнього та внутрішнього середовищ підприємств в цих умовах. В статті підкреслено необхідність використання контролінгу у якості інструменту стратегічного управління, який дозоляє прогнозувати та виявляти ризики на підприємствах для своєчасної зміни стратегії або її корегування відповідно новим загрозам та можливостям.