bluuebunny/crossref_metadata_2025 huggingface dataset:
Ferromagnetic nematics: A macroscopic two-fluid description
Authors: Pleiner Harald , Brand Helmut R.
Published: January 2022

We present the macroscopic dynamic description of a ferromagnetic nematic, where the nematic part and the magnetic part can move relative to each other. The relative velocity that describes such movements can be a slowly relaxing variable. Its couplings to the nematic and the magnetic degrees of freedom are particularly interesting since the symmetry properties (behavior under spatial inversion and time reversal) of the three vectorial quantities involved are all different. As a consequence, a number of new crosscouplings involving the relative velocity exist. Some of them are discussed in more detail. First, we demonstrate that transverse temperature gradients generate transverse relative velocities and, vice versa, that transverse relative velocities give rise to temperature gradients. Second, we show that a simple shear flow in the relative velocity with the preferred direction in the shear plane can lead in a stationary situation to a tilt of the magnetization.
On polarization
Authors: Baer Brian James
Published: January 2022

The ideological incommensurability of the worldviews or master narratives represented by the two opposing superpowers during the Cold War and embodied in the image of an impenetrable iron curtain gave particular salience to translation theory while also questioning the very possibility of translation. At the same time, the neoimperialist projects of the two superpowers produced startlingly similar approaches to the instrumentalization of translation as a vehicle for propaganda and diplomacy. Presenting polarization as a distinct state of semiosis, the effects of which are highly unpredictable, this article explores the various ways in which the radical polarization of the Cold War shaped the theory and practice of translation both within and across the ideological divide. Plotting the entanglements of the light and dark sides of translation during this time challenges traditional histories of the field that construe the period as one of progress and liberation.
Distance difference functions on nonconvex boundaries of Riemannian manifolds
Authors: Ivanov S.
Published: January 2022

It is shown that a complete Riemannian manifold with boundary is uniquely determined, up to isometry, by its distance difference representation on the boundary. Unlike previously known results, no restrictions on the boundary are imposed.
On the sharpness of assumptions in the Federer theorem
Authors: Makarov B. , Podkorytov A.
Published: January 2022

The Federer theorem deals with the “massiveness” of the set of critical values for a

t
t

-smooth map acting from

R

m

\mathbb R^m

to

R

n

\mathbb R^n

: it claims that the Hausdorff

p
p

-measure of this set is zero for certain

p
p

. If

n
≥
m

n\ge m

, it has long been known that the assumption of that theorem relating the parameters

m
,
n
,
t
,
p

m,n,t,p

is sharp. Here it is shown by an example that this assumption is also sharp for

n
>
m

n>m

.
Chromosomal imbalances detected via RNA-sequencing in 28 cancers
Authors: Ozcan Zuhal , San Lucas Francis A , Wong Justin W , Chang Kyle , Stopsack Konrad H , Fowler Jerry , Jakubek Yasminka A , Scheet Paul
Published: January 2022

Motivation

RNA-sequencing (RNA-seq) of tumor tissue is typically only used to measure gene expression. Here, we present a statistical approach that leverages existing RNA-seq data to also detect somatic copy number alterations (SCNAs), a pervasive phenomenon in human cancers, without a need to sequence the corresponding DNA.

Results

We present an analysis of 4942 participant samples from 28 cancers in The Cancer Genome Atlas (TCGA), demonstrating robust detection of SCNAs from RNA-seq. Using genotype imputation and haplotype information, our RNA-based method had a median sensitivity of 85% to detect SCNAs defined by DNA analysis, at high specificity (∼95%). As an example of translational potential, we successfully replicated SCNA features associated with breast cancer subtypes. Our results credential haplotype-based inference based on RNA-seq to detect SCNAs in clinical and population-based settings.

Availability and implementation

The analyses presented use the data publicly available from TCGA Research Network (http://cancergenome.nih.gov/). See Methods for details regarding data downloads. hapLOHseq software is freely available under The MIT license and can be downloaded from http://scheet.org/software.html.

Supplementary information

Supplementary data are available at Bioinformatics online.
COPD is associated with increased pro-inflammatory CD28null CD8 T and NKT-like cells in the small airways
Authors: Hodge Greg , Jersmann Hubertus , Tran Hai B , Asare Patrick F , Jayapal Minnu , Reynolds Paul N , Holmes Mark , Hodge Sandra
Published: January 2022

We previously showed increased steroid-resistant CD28null CD8+ senescent lymphocyte subsets in the peripheral blood from patients with chronic obstructive pulmonary disease (COPD). These cells expressed decreased levels of the glucocorticoid receptor (GCR), suggesting their contribution to the steroid-resistant property of these cells. COPD is a disease of the small airways (SA). We, therefore, hypothesized that there would be a further increase in these steroid-resistant lymphocytes in the lung, particularly in the SA. We further hypothesized that the pro-inflammatory/cytotoxic potential of these cells could be negated using prednisolone with low-dose cyclosporin A. Blood, bronchoalveolar lavage, large proximal, and small distal airway brushings were collected from 11 patients with COPD and 10 healthy aged-matched controls. The cytotoxic mediator granzyme b, pro-inflammatory cytokines IFNγ/TNFα, and GCR were determined in lymphocytes subsets before and after their exposure to 1µM prednisolone and/or 2.5 ng/mL cyclosporin A. Particularly in the SA, COPD subjects showed an increased percentage of CD28null CD8 T-cells and NKT-like cells, with increased expression of granzyme b, IFNγ and TNFα and a loss of GCR, compared with controls. Significant negative correlations between SA GCR expression and IFNγ/TNFα production by T and NKT-like cells (eg, T-cell IFNγ R = −0.834, P = 0.031) and with FEV1 (R = −0.890) were shown. Cyclosporine A and prednisolone synergistically increased GCR expression and inhibited pro-inflammatory cytokine production by CD28null CD8− T and NKT-like cells. COPD is associated with increased pro-inflammatory CD28null CD8+ T and NKT-like cells in the SA. Treatments that increase GCR in these lymphocyte subsets may improve the efficacy of clinical treatment.
Evaluation of Serum Mucorales Polymerase Chain Reaction (PCR) for the Diagnosis of Mucormycoses: The MODIMUCOR Prospective Trial
Authors: Millon Laurence , Caillot Denis , Berceanu Ana , Bretagne Stéphane , Lanternier Fanny , Morio Florent , Letscher-Bru Valérie , Dalle Frédéric , Denis Blandine , Alanio Alexandre , Boutoille David , Bougnoux Marie Elisabeth , Botterel Françoise , Chouaki Taieb , Charbonnier Amandine , Ader Florence , Dupont Damien , Bellanger Anne Pauline , Rocchi Steffi , Scherer Emeline , Gbaguidi-Haore Houssein , Herbrecht Raoul
Published: January 2022

Background

Early diagnosis and prompt initiation of specific antifungal treatment are essential for improving the prognosis of mucormycosis. We aimed to assess the performance of serum Mucorales quantitative polymerase chain reaction (qPCR) for the early diagnosis and follow-up of mucormycosis.

Methods

We prospectively enrolled 232 patients with suspicion of invasive mold disease, evaluated using standard imaging and mycological procedures. Thirteen additional patients with proven or probable mucormycosis were included to analyze DNA load kinetics. Serum samples were collected twice-a-week for Mucorales qPCR tests targeting the Mucorales genera Lichtheimia, Rhizomucor, and Mucor/Rhizopus.

Results

The sensitivity was 85.2%, specificity 89.8%, and positive and negative likelihood ratios 8.3 and 0.17, respectively in this prospective study. The first Mucorales qPCR-positive serum was observed a median of 4 days (interquartile range [IQR], 0–9) before sampling of the first mycological or histological positive specimen and a median of one day (IQR, −2 to 6) before the first imaging was performed. Negativity of Mucorales qPCR within seven days after liposomal-amphotericin B initiation was associated with an 85% lower 30-day mortality rate (adjusted hazard ratio = 0·15, 95% confidence interval [.03–.73], P = .02).

Conclusions

Our study argues for the inclusion of qPCR for the detection of circulating Mucorales DNA for mucormycosis diagnosis and follow-up after treatment initiation. Positive results should be added to the criteria for the consensual definitions from the European Organization for the Research and Treatment of Cancer/Mycoses Study Group Education and Research Consortium (EORTC/MSGERC), as already done for Aspergillus PCR.
The evolution of larger size in high-altitude Drosophila melanogaster has a variable genetic architecture
Authors: Sprengelmeyer Quentin D , Lack Justin B , Braun Dylan T , Monette Matthew J , Pool John E
Published: January 2022

Important uncertainties persist regarding the genetic architecture of adaptive trait evolution in natural populations, including the number of genetic variants involved, whether they are drawn from standing genetic variation, and whether directional selection drives them to complete fixation. Here, we take advantage of a unique natural population of Drosophila melanogaster from the Ethiopian highlands, which has evolved larger body size than any other known population of this species. We apply a bulk segregant quantitative trait locus mapping approach to 4 unique crosses between highland Ethiopian and lowland Zambian populations for both thorax length and wing length. Results indicated a persistently variable genetic basis for these evolved traits (with largely distinct sets of quantitative trait loci for each cross), and at least a moderately polygenic architecture with relatively strong effects present. We complemented these mapping experiments with population genetic analyses of quantitative trait locus regions and gene ontology enrichment analysis, generating strong hypotheses for specific genes and functional processes that may have contributed to these adaptive trait changes. Finally, we find that the genetic architectures indicated by our quantitative trait locus mapping results for size traits mirror those from similar experiments on other recently evolved traits in this species. Collectively, these studies suggest a recurring pattern of polygenic adaptation in this species, in which causative variants do not approach fixation and moderately strong effect loci are present.
Influence of Sex, Smoking and Age on Human hprt Mutation Frequencies and Spectra
Authors: Curry John , Karnaoukhova Larissa , Guenette Gabriel C , Glickman Barry W
Published: January 2022

Examination of the literature for hprt mutant frequencies from peripheral T cells yielded data from 1194 human subjects. Relationships between mutant frequency, age, sex, and smoking were examined, and the kinetics were described. Mutant frequency increases rapidly with age until about age 15. Afterward, the rate of increase falls such that after age 53, the hprt mutant frequency is largely stabilized. Sex had no effect on mutant frequency. Cigarette smoking increased mean mutant frequency compared to nonsmokers, but did not alter age vs. mutant frequency relationships. An hprt in vivo mutant database containing 795 human hprt mutants from 342 individuals was prepared. No difference in mutational spectra was observed comparing smokers to nonsmokers, confirming previous reports. Sex affected the frequency of deletions (>1 bp) that are recovered more than twice as frequently in females (P = 0.008) compared to males. There is no indication of a significant shift in mutational spectra with age for individuals older than 19 yr, with the exception of A:T → C:G transversions. These events are recovered more frequently in older individuals.
Meta-analysis Integrated With Multi-omics Data Analysis to Elucidate Pathogenic Mechanisms of Age-Related Knee Osteoarthritis in Mice
Authors: Iijima Hirotaka , Gilmer Gabrielle , Wang Kai , Sivakumar Sruthi , Evans Christopher , Matsui Yusuke , Ambrosio Fabrisia
Published: January 2022

Increased mechanistic insight into the pathogenesis of knee osteoarthritis (KOA) is needed to develop efficacious disease-modifying treatments. Though age-related pathogenic mechanisms are most relevant to the majority of clinically presenting KOA, the bulk of our mechanistic understanding of KOA has been derived using surgically induced posttraumatic OA (PTOA) models. Here, we took an integrated approach of meta-analysis and multi-omics data analysis to elucidate pathogenic mechanisms of age-related KOA in mice. Protein-level data were integrated with transcriptomic profiling to reveal inflammation, autophagy, and cellular senescence as primary hallmarks of age-related KOA. Importantly, the molecular profiles of cartilage aging were unique from those observed following PTOA, with less than 3% overlap between the 2 models. At the nexus of the 3 aging hallmarks, advanced glycation end product (AGE)/receptor for AGE (RAGE) emerged as the most statistically robust pathway associated with age-related KOA. This pathway was further supported by analysis of mass spectrometry data. Notably, the change in AGE–RAGE signaling over time was exclusively observed in male mice, suggesting sexual dimorphism in the pathogenesis of age-induced KOA in murine models. Collectively, these findings implicate dysregulation of AGE–RAGE signaling as a sex-dependent driver of age-related KOA.
Dashboard-Driven Accelerated Infliximab Induction Dosing Increases Infliximab Durability and Reduces Immunogenicity
Authors: Dubinsky Marla C , Mendiolaza Michelle L , Phan Becky L , Moran Hunter R , Tse Stacy S , Mould Diane R
Published: January 2022

Background and Aims

Accelerated infliximab (IFX) induction is often based on clinical parameters as opposed to pharmacokinetics (PK). We aimed to investigate the impact of dashboard-guided optimized induction dosing on IFX durability and immunogenicity in a real-world inflammatory bowel disease (IBD) setting.

Methods

Pediatric and adult IBD patients were enrolled in a prospective single arm intervention trial. Cumulative data from each infusion (INF), weight, albumin, C-reactive protein, IFX dose, IFX trough level, and antidrug antibody presence were used to inform subsequent INF dosing. Forecasts driven by adaptive Bayesian modeling were generated to maintain trough levels for the third (INF3) and fourth (INF4) infusions of 17 μg/mL and 10 μg/mL, respectively. The primary outcome was proportion of patients prescribed accelerated dosing (AD) intervals by INF3 (<22 days) or INF4 (<49 days). Secondary outcomes included week 52 clinical and PK outcomes. Multivariate analyses and Kaplan-Meier curves compared outcomes based on adherence to dashboard forecasts.

Results

Of the 180 per-protocol population, AD was forecast for 41% (INF3) and 69% (INF4) of patients with median intervals of 17 (INF3) and 39 (INF4) days. Baseline age >18 years, albumin >3.5 g/L, and 10-mg/kg dose were independently associated with lower rates of AD by INF4. Nonadherence with the INF4 forecast (n = 39) was an independent predictor of antidrug antibody (P < .0001) and IFX discontinuation (P = .0006). A total of 119 of 123 patients on IFX at week 52 were in steroid-free remission.

Conclusions

The application of a PK dashboard during induction can optimize dosing early to improve IFX durability and immunogenicity.
AreMostandMore Than HalfTruth-Conditionally Equivalent?
Authors: Denić Milica , Szymanik Jakub
Published: January 2022

Quantifying determiners most and more than half are standardly assumed to have the same truth-conditional meaning. Much work builds on this assumption in studying how the two quantifiers are mentally encoded and processed (Hackl, 2009; Lidz et al., 2011; Pietroski et al., 2009; Steinert-Threlkeld et al., 2015; Szymanik & Zajenkowski, 2010; Talmina et al., 2017). There is however empirical evidence that most is sometimes interpreted as ‘significantly more than half’ (Ariel, 2003, 2004; Ramotowska et al., 2020; Solt, 2011, 2016). Is this difference between most and more than half a pragmatic effect, or is the standard assumption that the two quantifiers are truth-conditionally equivalent wrong? We report two experiments which demonstrate that most preserves the ‘significantly more than half’ interpretation in negative environments, which we argue to speak in favor of there being a difference between the two quantifiers at the level of truth conditions.
Cryopreserved aortic homograft, lifeline treatment for infected vascular prosthesis with mediastinal abscess in a re-redo case
Authors: Rufa Magdalena , Ursulescu Adrian , Stan Alina , Göbel Nora , Albert Marc , Franke Ulrich F W
Published: January 2022

We report about a 61-year-old man who, 6 years after initial uncomplicated mitral valve repair and 3 months after treatment of a pseudo-aneurysm of the ascending aorta with a Dacron patch, was admitted in our institution with an infection of the vascular graft, which was associated with sternal osteomyelitis and purulent cutaneous fistula. In a re-redo procedure, the proximal aortic arch and the ascending aorta were replaced with a cryopreserved aortic homograft. The infected part of the sternum was resected and the defect was covered by mobilizing the mediastinal tissue and with a bilateral muscle flap. The patient was discharged 20 days after surgery. This treatment concept outlines the benefit of cryopreserved aortic homograft when faced with a complex thoracic aortic infection.
Cerebral metastases of malignant mesothelioma
Authors: Bathini Abhijith , Kusyk Dorian M , Stabingas Kristen , Kujawski Brandon , Ahn Janice , Williamson Richard
Published: January 2022

Malignant pleural mesothelioma represents a rare etiology of lung cancer metastasis to the brain. Neurologically symptomatic presentations are extremely rare as these metastatic lesions are detected in the late stages of the disease. Despite many highly heterogenous treatment techniques reported in the literature, overall survival is poor. A 72-year-old male with a history of mesothelioma presented with recurrent episodes of altered mental status, confusion and expressive aphasia. Imaging indicated a large hemorrhagic, enhancing lesion in the anterior left frontal lobe resulting in midline shift of 6 mm. He underwent a left frontal craniotomy for resection, after which he had complete resolution of symptoms. The resected mass was metastatic high-grade malignant mesothelioma. On a 1-month follow-up, new lesions in the bilateral frontal lobes were discovered, and despite undergoing adjuvant stereotactic radiosurgery, the right one grew significantly, causing notable mass effect. The patient successfully underwent a right craniotomy for resection.
Epoch of reionization parameter estimation with the 21-cm bispectrum
Authors: Watkinson Catherine A , Greig Bradley , Mesinger Andrei
Published: January 2022

We present the first application of the isosceles bispectrum to MCMC parameter inference from the cosmic 21-cm signal. We extend the MCMC sampler 21CMMC to use the fast bispectrum code, BiFFT, when computing the likelihood. We create mock 1000-h observations with SKA1-low, using pyObs21 to account for uv-sampling and thermal noise. Assuming the spin temperature is much higher than that of the cosmic microwave background, we consider two different reionization histories for our mock observations: fiducial and late-reionization. For both models we find that bias on the inferred parameter means and 1σ credible intervals can be substantially reduced by using the isosceles bispectrum (calculated for a wide range of scales and triangle shapes) together with the power spectrum (as opposed to just using one of the statistics). We find that making the simplifying assumption of a Gaussian likelihood with a diagonal covariance matrix does not notably bias parameter constraints for the three-parameter reionization model and basic instrumental effects considered here. This is true even if we use extreme (unlikely) initial conditions which would be expected to amplify biases. We also find that using the cosmic variance error calculated with Monte Carlo simulations using the fiducial model parameters while assuming the late-reionization model for the simulated data also does not strongly bias the inference. This implies we may be able to sparsely sample and interpolate the cosmic variance error over the parameter space, substantially reducing computational costs. All codes used in this work are publicly available.
The effect of hierarchical structure of the surface dust layer on the modelling of comet gas production
Authors: Skorov Yu , Reshetnyk V , Bentley M S , Rezac L , Hartogh P , Blum J
Published: January 2022

A hierarchical model of microstructure of cometary dust seems to accurately capture the morphological complexity of these particles as observed by the Rosetta mission to the 67P/Churyumov–Gerasimenko. The main aim of this work is to investigate how uncertainties in the knowledge of the microstructure of the surface layer affect our estimates of gas production. New models that incorporate scale of inhomogenieties in a sound theoretical framework are used for hierarchical dust layers. The studied layers are constructed in two steps: first we design ballistic aggregates as the building units and then, using these porous blocks, assemble the layers constrained by the known porosity range. The mean pore size and permeability are studied. Modelling is performed for various values of porosity, grain size, and layer thickness. The simulation results are embedded in the thermal model, explicitly including a radiation thermal conductivity and a resistance of the dust layer for the gas flow. It is shown that the average pore size is satisfactorily approximated by a linear function of the ratio of the effective porosity of the layer to the degree of filling. Simple fittings were obtained for the layer permeability. Our results indicate that in the expected range of nucleus porosity, the gas production rate is weakly dependent on the detailed layer microstructure, and appropriate effective values of homogeneous dust layers can be used to evaluate the gas activity. We also note that adding complex elements into the model yields unavoidable statistical uncertainties within several tens of per cent.
Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products
Authors: Moll Guido , Ankrum James A , Olson Scott D , Nolta Jan A
Published: January 2022

The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical applications have greatly diversified during the past decade, including rapid growth of poorly regulated “Stem Cell Clinics” offering diverse “Unproven Stem Cell Interventions.” This product diversification necessitates a critical evaluation of the reliance on the 2006 MSC minimal criteria to not only define MSC identity but characterize MSC suitability for intravascular administration. While high-quality MSC therapeutics have been safely administered intravascularly in well-controlled clinical trials, repeated case reports of mild-to-more-severe adverse events have been reported. These are most commonly related to thromboembolic complications upon infusion of highly procoagulant tissue factor (TF/CD142)-expressing MSC products. As TF/CD142 expression varies widely depending on the source and manufacturing process of the MSC product, additional clinical cell product characterization and guidelines are needed to ensure the safe use of MSC products. To minimize risk to patients receiving MSC therapy, we here propose to supplement the minimal criteria used for characterization of MSCs, to include criteria that assess the suitability of MSC products for intravascular use. If cell products are intended for intravascular delivery, which is true for half of all clinical applications involving MSCs, the effects of MSC on coagulation and hemocompatibility should be assessed and expression of TF/CD142 should be included as a phenotypic safety marker. This adjunct criterion will ensure both the identity of the MSCs as well as the safety of the MSCs has been vetted prior to intravascular delivery of MSC products.
Significant variations in preoperative fluid resuscitation volumes delivered to elderly hip fracture patients at six level 1 trauma centers: an observational descriptive study
Authors: Willis Jordan , Pelzl Casey E. , Jarvis Stephanie , Berg Gina , Corrigan Chad , Madayag Robert , Reynolds Cassandra , Tanner Allen , Marshall Gary , Lieser Mark , Bar-Or David
Published: January 2022

Objective:

To describe the variations in administration of preoperative (preop) fluids and in the volumes of fluid administered among geriatric hip fracture patients requiring surgical repair.

Design:

Observational descriptive.

Setting:

Six Level 1 trauma centers.

Patients:

A total of 595 patients aged ≥65 with ICD-10 codes indicating hip fracture and surgical repair were identified. Of these, 87.9% (n = 525) received preop fluid. The median volume of preop fluid delivered was 1500 mL (IQR: 1000–2250 mL).

Intervention:

None.

Main Outcome Measures:

Receipt of preop fluids; median volume of fluid received.

Results:

Receipt of preop fluid was significantly different by inter-hospital transfer, facility, BMI, hospital length of stay, and postop fluid volume. Age, sex, time to surgery, time to ambulation, and hospital disposition were not associated with preop fluid. There were significant differences in median preop fluid volumes by facility and postop fluid volume.

Conclusion:

This descriptive study of current practices among geriatric trauma patients with isolated hip fractures revealed significant differences in the use of preop fluid resuscitation and the resuscitation volumes administered. Treating facility may be the most substantial source of variation highlighting the need for a guideline on fluid resuscitation. These observed variations may be a result of patient characteristics or provider discretion and should be evaluated further.
Induced side-branching in smooth and faceted dendrites: theory and phase-field simulations
Authors: Demange Gilles , Patte Renaud , Zapolsky Helena
Published: January 2022

The present work is devoted to the phenomenon of induced side branching stemming from the disruption of free dendrite growth. We postulate that the secondary branching instability can be triggered by the departure of the morphology of the dendrite from its steady state shape. Thence, the instability results from the thermodynamic trade-off between non monotonic variations of interface temperature, surface energy, kinetic anisotropy and interface velocity within the Gibbs–Thomson equation. For the purposes of illustration, the toy model of capillary anisotropy modulation is prospected both analytically and numerically by means of phase-field simulations. It is evidenced that side branching can befall both smooth and faceted dendrites, at a normal angle from the front tip which is specific to the nature of the capillary anisotropy shift applied.

This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.
Rapid eutectic growth: from rod growth to diffusionless solidification
Authors: Galenko Peter K. , Xu Junfeng
Published: January 2022

Numerous experimental data on the rapid solidification of eutectic systems exhibit the formation of metastable solid phases with the initial (nominal) chemical composition. This fact is explained by the suppression of eutectic decomposition due to diffusionless (chemically partitionless) solidification beginning at a high but finite growth velocity of crystals. In the present work, a model is suggested for the diffusionless growth to analyse the atomic diffusion in the rod eutectic couples growing into supercooled liquid. A simplified calculating method for the equation related to the Bessel function in the solution of the growth of rod eutectics is obtained. This method can also be used in the calculation of other rod eutectic growth models.

This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.
Dynamic magnetic birefringence in a viscoelastic ferrocolloid
Authors: Rusakov V. V. , Raikher Y. L.
Published: January 2022

A model is developed to describe the oscillations of optical anisotropy induced in a viscoelastic ferrocolloid (nanodispersion of magnetic particles) by an AC magnetic field. The viscoelasticity of the matrix (carrier medium) is assumed to obey the Jeffreys rheological scheme, whose advantage is that with the aid of just two viscous parameters and a single one for elasticity it enables one to vary the retarded mechanical response of the carrier from a weakly Maxwellian fluid to a medium with the rheology of a Kelvin gel. As the orientational motion of the particles driven by the AC field is always strongly affected by thermal motion, the occurring process is described with the aid of a kinetic (Fokker–Planck type) equation that combines diffusional and drift terms. On this basis, an exact evolution equation for the macroscopic optical anisotropy of a ferrocolloid is derived that is, however, just one link in an infinite chain of equations for statistical moments. The solution is obtained by applying effective field approximation: reducing the number of moment equations to their minimum and closing the chosen set. This solution is substituted to the scheme of a standard polarimetric set-up, and it is demonstrated how the peculiarities imparted by viscoelasticity should manifest themselves on the intensity of the light transmitted through the set up containing a ferrocolloid sample.

This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.
Predicting concurrent structural mechanical mechanisms during microstructure evolution
Authors: Soar P. , Kao A. , Shevchenko N. , Eckert S. , Djambazov G. , Pericleous K.
Published: January 2022

The interdependence between structural mechanics and microstructure solidification has been widely observed experimentally as a factor leading to undesirable macroscopic properties and casting defects. Despite this, numerical modelling of microstructure solidification often neglects this interaction and is therefore unable to predict key mechanisms such as the development of misoriented grains. This paper presents a numerical method coupling a finite volume structural mechanics solver to a cellular automata solidification solver, where gravity or pressure-driven displacements alter the local orientation and thereby growth behaviour of the solidifying dendrites. Solutions obtained using this model are presented which show fundamental behaviours observed in experiments. The results show that small, localized deformations can lead to significant changes in the crystallographic orientation of a dendrite and ultimately affect the overall microstructure development.

This article is part of the theme issue 'Transport phenomena in complex systems (part 2)'.
Transport phenomena in complex systems (part 2)
Authors: Alexandrov Dmitri V. , Zubarev Andrey Yu.
Published: January 2022

This theme issue, in two parts, continues research studies of transport phenomena in complex media published in the first part (Alexandrov & Zubarev 2021
Phil. Trans. R. Soc. A
379
, 20200301. (
doi:10.1098/rsta.2020.0301
)). The issue is concerned with theoretical, numerical and experimental investigations of nonlinear transport phenomena in heterogeneous and metastable materials of different nature, including biological systems. The papers are devoted to the new effects arising in such systems (e.g. pattern and microstructure formation in materials, impacts of external processes on their properties and evolution and so on). State-of-the-art methods of numerical simulations, stochastic analysis, nonlinear physics and experimental studies are presented in the collection of issue papers.

This article is part of the theme issue ‘Transport phenomena in complex systems (part 2)’.
Transplantation of IPSC-Derived Cardiomyocyte Patches for Ischemic Cardiomyopathy
Authors: Miyagawa Shigeru , Kainuma Satoshi , Kawamura Takuji , Suzuki Kota , Ito Yoshito , Iseoka Hiroko , Ito Emiko , Takeda Maki , Sasai Masao , Mochizuki-Oda Noriko , Shimamoto Tomomi , Nitta Yukako , Dohi Hiromi , Watabe Tadashi , Sakata Yasushi , Toda Koichi , Sawa Yoshiki
Published: January 2022

Background

Despite major therapeutic advances, heart failure remains a life-threatening disorder, with 26 million patients worldwide, causing more deaths than cancer as a non-communicable disease. Therefore, novel strategies for the treatment of heart failure continue to be an important clinical need. Based on preclinical studies, allogenic human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) patches have been proposed as a potential therapeutic candidate for heart failure. We report the implantation of allogeneic hiPSC-CM patches in a patient with ischemic cardiomyopathy (ClinicalTrials.gov, #jRCT2053190081).

Methods

The patches were produced under clinical-grade conditions and displayed cardiogenic phenotypes and safetyin vivo(severe immunodeficient mice) without any genetic mutations in cancer-related genes. The patches were then implanted via thoracotomy into the left ventricle epicardium of the patient under immunosuppressive agents.

Results

Positron emission tomography and computed tomography confirmed the possible efficacy and did not detect tumorigenesis in either the heart or other organs; the clinical symptoms improved 6 months after surgery, without any major adverse events, suggesting that the patches were well-tolerated. Furthermore, changes in the wall motion in the transplanted site were recovered, suggesting a favorable prognosis and the potential tolerance to exercise.

Conclusions

This study is the first report of a successful transplant of hiPSC-CMs for severe ischemic cardiomyopathy.
Transition of antibody titers after the SARS-CoV-2 mRNA vaccine in Japanese healthcare workers
Authors: Kitabatake Masahiro , Ouji-Sageshima Noriko , Sonobe Shota , Furukawa Ryutaro , Konda Makiko , Hara Atsushi , Aoki Hiroyasu , Suzuki Yuki , Imakita Natsuko , Nakano Akiyo , Fujita Yukio , Shichino Shigeyuki , Nakano Ryuichi , Ueha Satoshi , Kasahara Kei , Muro Shigeo , Yano Hisakazu , Matsushima Kouji , Ito Toshihiro
Published: January 2022

Since February 2021, health care workers in Japan have been preferentially vaccinated with a messenger RNA vaccine (BNT162b2/Pfizer) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While many studies have confirmed that this vaccine is highly effective in reducing hospitalizations and deaths from coronavirus disease 2019 (COVID-19), antibody titers tend to decline at 3 months, leading to a risk of breakthrough infections. Thus, information is needed to support decision making regarding the third vaccination. In this study, we investigated transition of the anti-SARS-CoV-2 receptor-binding domain (RBD) IgG and neutralizing antibody titers of 41 vaccinated Japanese healthcare workers. Samples were collected seven times starting 1 week before vaccination until 6 months post-vaccination. Anti-SARS-CoV-2 RBD IgG levels peaked at 7 days after the booster, then declined over time and decreased to <10% at 6 months after the booster. Workers with low anti-SARS-CoV-2 RBD IgG levels also had low neutralizing antibody titers. These data support the active use of boosters for healthcare workers, especially for those with low anti-SARS-CoV-2 RBD IgG levels.
Non-modifiable factors as moderators of the relationship between physical activity and brain volume: A cross-sectional UK Biobank study
Authors: Brown Belinda M , de Frutos Lucas Jaisalmer , Porter Tenielle , Frost Natalie , Vacher Michael , Peiffer Jeremiah J , Laws Simon M
Published: January 2022

Background

Grey matter atrophy occurs as a function of ageing and is accelerated in dementia. Previous research suggests physical activity attenuates grey matter loss; however, there appears to be individual variability in this effect. Understanding factors that can affect the relationship between physical activity and brain volume may enable prediction of individual response, and aid in identifying those that gain the greatest neural benefits from physical activity. The current study examined the relationship between objectively-measured physical activity and brain volume; and whether this relationship is moderated by age, sex, or a priori candidate genetic factors.

Methods

Data from 10,083 men and women (50 years and over) of the UK Biobank were used to examine: 1) the relationship between objectively-measured physical activity and brain volume; and 2) whether the relationship between objectively-measured physical activity and brain volume is moderated by age, sex, brain-derived neurotrophic factor (BDNF) Val66Met, or apolipoprotein (APOE) ε4 allele carriage. All participants underwent a magnetic resonance imaging scan to quantify grey matter volumes, physical activity monitoring via accelerometry, and genotyping.

Results

Physical activity was associated with total grey matter volume (B = 0.14, p = 0.001, q = 0.005) and right hippocampal volume (B = 1.45, p = 0.008, q = 0.016). The physical activity*sex interaction predicted cortical grey matter (B = 0.22, p = 0.003, q = 0.004), total grey matter (B = 0.30, p < 0.001, q = 0.001), and right hippocampal volume (B = 3.60, p = 0.001, q = 0.002). Post-hoc analyses revealed males received benefit from higher physical activity levels, in terms of greater cortical grey matter volume (B = 0.13, p = 0.01), total grey matter volume (B=0.23, p < 0.001), and right hippocampal volume (B = 3.05, p = 0.008). No moderating effects of age, APOE ε4 allele carriage, or BDNF Val66Met genotype were observed.

Discussion

Our results indicate that in males, but not females, an association exists between objectively-measured physical activity and grey matter volume. Future research should evaluate longitudinal brain volumetrics to better understand the nature of sex-effects on the relationship between physical activity and brain volume.
Regional pleural strain measurements during mechanical ventilation using ultrasound elastography: A randomised, crossover, proof of concept physiologic study
Authors: Girard Martin , Roy Cardinal Marie-Hélène , Chassé Michaël , Garneau Sébastien , Cavayas Yiorgos Alexandros , Cloutier Guy , Denault André Y.
Published: January 2022

Background

Mechanical ventilation is a common therapy in operating rooms and intensive care units. When ill-adapted, it can lead to ventilator-induced lung injury (VILI), which is associated with poor outcomes. Excessive regional pulmonary strain is thought to be a major mechanism responsible for VILI. Scarce bedside methods exist to measure regional pulmonary strain. We propose a novel way to measure regional pleural strain using ultrasound elastography.

Research Question

The objective of this study was to assess the feasibility and reliability of pleural strain measurement by ultrasound elastography and to determine if elastography parameters would correlate with varying tidal volumes.

Study Design and Methods

A single-blind randomized crossover proof of concept study was conducted July to October 2017 at a tertiary care referral center. Ten patients requiring general anesthesia for elective surgery were recruited. After induction, patients were received tidal volumes of 6, 8, 10 and 12 mL.kg-1 in random order, while pleural ultrasound cineloops were acquired at 4 standardized locations. Ultrasound radiofrequency speckle tracking allowed computing various pleural translation, strain and shear components. These were screened to identify those with the best dose-response with tidal volumes using linear mixed effect models. Goodness-of-fit was assessed by the coefficient of determination. Intraobserver, interobserver and test-retest reliability were calculated using intraclass correlation coefficients.

Results

Analysis was possible in 90.7% of ultrasound cineloops. Lateral absolute shear, lateral absolute strain and Von Mises strain varied significantly with tidal volume and offered the best dose-responses and data modelling fits. Point estimates for intraobserver reliability measures were excellent for all 3 parameters (0.94, 0.94 and 0.93, respectively). Point estimates for interobserver (0.84, 0.83 and 0.77, respectively) and test-retest (0.85, 0.82 and 0.76, respectively) reliability measures were good.

Interpretation

Strain imaging is feasible and reproducible, and may eventually guide mechanical ventilation strategies in larger cohorts of patients.
Artificial intelligence technologies for more flexible recommendation in uniforms
Authors: Wen Chih-Hao , Cheng Chih-Chan , Shih Yuh-Chuan
Published: January 2022

Purpose

This research aims to collect human body variables via 2D images captured by digital cameras. Based on those human variables, the forecast and recommendation of the Digital Camouflage Uniforms (DCU) for Taiwan's military personnel are made.

Design/methodology/approach

A total of 375 subjects are recruited (male: 253; female: 122). In this study, OpenPose converts the photographed 2D images into four body variables, which are compared with those of a tape measure and 3D scanning simultaneously. Then, the recommendation model of the DCU is built by the decision tree. Meanwhile, the Euclidean distance of each size of the DCU in the manufacturing specification is calculated as the best three recommendations.

Findings

The recommended size established by the decision tree is only 0.62 and 0.63. However, for the recommendation result of the best three options, the DCU Fitting Score can be as high as 0.8 or more. The results of OpenPose and 3D scanning have the highest correlation coefficient even though the method of measuring body size is different. This result confirms that OpenPose has significant measurement validity. That is, inexpensive equipment can be used to obtain reasonable results.

Originality/value

In general, the method proposed in this study is suitable for applications in e-commerce and the apparel industry in a long-distance, non-contact and non-pre-labeled manner when the world is facing Covid-19. In particular, it can reduce the measurement troubles of ordinary users when purchasing clothing online.
Mental health of business academics within the COVID-19 era: can meaningful work help? A qualitative study
Authors: Mousa Mohamed , Samara Georges
Published: January 2022

Purpose

Through addressing academics in four public business schools in Egypt, the authors of this paper aim to uncover how meaningful work might shape the mental health of the addressed academics post COVID-19.

Design/methodology/approach

The author employed a qualitative research method through semi-structured interviews with 44 academics from four business schools selected from among 25 public institutions of higher education in Egypt. The author subsequently used thematic analysis to determine the main ideas in the transcripts.

Findings

The authors’ findings show that business academics usually consider meaningful work as playing a major role in shaping their mental health, especially after a crisis. This indicates that the more they perceive their jobs as valuable and worthwhile, the more they can deal with limitations and mental health issues (e.g. anxiety, stress, inadequate sleep, etc.) that accompany crisis. The findings also show that during the time of the COVID-19 crisis, employees (business academics in this case) have not placed so much importance to their autonomy (ability to choose and/or participate in decision-making processes) in the workplace. Instead, they care more about their relatedness (sense of belongingness) and their level of competence (sense of capability). Accordingly, the authors show that having academics that develop a sense of purpose for their academic duties in a time of crisis has less mental health disorders. Subsequently, post crisis, business academics can feel a continuous sense of relatedness and find ongoing opportunities to work and learn.

Originality/value

This paper contributes by filling a gap in HR management, in which empirical studies on the relationship between mental health and meaningful work have been limited so far.
Data-driven bus timetabling with spatial-temporal travel time
Authors: Li Xiang , Yang Ming , Ma Hongguang , Yu Kaitao (Stella)
Published: January 2022

Purpose

Travel time at inter-stops is a set of important parameters in bus timetabling, which is usually assumed to be normal (log-normal) random variable in literature. With the development of digital technology and big data analytics ability in the bus industry, practitioners prefer to generate deterministic travel time based on the on-board GPS data under maximum probability rule and mean value rule, which simplifies the optimization procedure, but performs poorly in the timetabling practice due to the loss of uncertain nature on travel time. The purpose of this study is to propose a GPS-data-driven bus timetabling approach with consideration of the spatial-temporal characteristic of travel time.

Design/methodology/approach

The authors illustrate that the real-life on-board GPS data does not support the hypothesis of normal (log-normal) distribution on travel time at inter-stops, thereby formulating the travel time as a scenario-based spatial-temporal matrix, where K-means clustering approach is utilized to identify the scenarios of spatial-temporal travel time from daily observation data. A scenario-based robust timetabling model is finally proposed to maximize the expected profit of the bus carrier. The authors introduce a set of binary variables to transform the robust model into an integer linear programming model, and speed up the solving process by solution space compression, such that the optimal timetable can be well solved by CPLEX.

Findings

Case studies based on the Beijing bus line 628 are given to demonstrate the efficiency of the proposed methodology. The results illustrate that: (1) the scenario-based robust model could increase the expected profits by 15.8% compared with the maximum probability model; (2) the scenario-based robust model could increase the expected profit by 30.74% compared with the mean value model; (3) the solution space compression approach could effectively shorten the computing time by 97%.

Originality/value

This study proposes a scenario-based robust bus timetabling approach driven by GPS data, which significantly improves the practicality and optimality of timetable, and proves the importance of big data analytics in improving public transport operations management.