bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of X-ray Microtomography in Dental Science
Authors: Costa Teles Gabriel José , Machado Alessandra , Lopes Ricardo
Published: February 2025

This study delves into the application of X-ray microtomography (microCT) in dental sciences, displaying its ability to provide detailed and non-destructive three-dimensional images of dental structures. Two primary studies were conducted: the first study examined the formation of dentinal cracks after root canal instrumentation in lower molars using different mechanized systems and evaluated the presence of debris after instrumentation. The second study assessed the removability of bioceramic cement combined with gutta-percha in lower premolars and quantified the remaining material after re-instrumentation of the canals. The results demonstrated that microCT is an essential tool for identifying cracks with micrometric precision and quickly quantifying debris and remaining obturation materials, underscoring its effectiveness in dental diagnosis and research. The research highlights the potential of microCT to enhance clinical outcomes in dentistry, significantly contributing to the development of new treatment techniques and materials. It suggests that this technology will become increasingly accessible and widely adopted.
Flora de las turberas tropicales de alta montaña: amenazas y medidas de manejo. Cordillera de Talamanca, Costa Rica
Authors: González Frank , León-Alfaro Yazmín , López-Estébanez Nieves
Published: February 2025

Introducción: Las turberas tropicales son formaciones vegetales muy frágiles, especialmente debido a los impactos antrópicos y a los cambios en las condiciones climáticas. Objetivo: Caracterizar la flora de las turberas de Talamanca, así como identificar sus dinámicas, amenazas e impactos. Métodos: Se analizó la flora de cinco turberas ubicadas en el Macizo Buenavista, a lo largo de la carretera Interamericana, a una altitud entre 2 400 - 3 100 m, a través de muestreos en campo. Posteriormente se diseñó un Índice de Valor Florístico (IVF) para valorar el estado de conservación. Resultados: Se determinó la riqueza florística en las turberas estudiadas. Se constató una menor diversidad biológica en las tres turberas ubicadas fuera de los espacios naturales protegidos estatales, lo que sugiere la influencia del efecto de borde y de las actividades agroproductivas o su proximidad a la carretera Interamericana. En contraste, las turberas Salsipuedes y Cerro Paramillo exhibieron una mayor diversidad, destacándose géneros como Blechnum, Puya, Chusquea, Myrsine y Vaccinium, en asociación con el género de briófitas Sphagnum. Se observó una composición floral distinta a lo largo de la franja cercana a la Interamericana, caracterizada por la presencia de especies con menor demanda hídrica, especialmente géneros como Rubus y Pteridium, entre otros. Conclusión: A partir de la composición florística identificada se determinó la importancia de las turberas como parte de los ecosistemas del Hotspot mesoamericano, no solo como depósitos de biodiversidad sino también como indicadores sensibles de la influencia humana y las amenazas ambientales en la región asociadas con impacto antrópico y cambio climático.
The impact of pelvic floor contraction on urethral mobility and urogenital hiatus size in pelvic floor ultrasound
Authors:   Gynecology and Obstetrics Clinic, NZOZ Ginekomed Dorota Dobek, Poland, Dobek-Brylińska Marta , Wlaźlak Edyta ,   Clinic of Operative and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland, Wlaźlak Wiktor ,   Clinic of Operative and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland, Krakowiak Jan ,   Department of Social Medicine, Chair of Social and Preventive Medicine, Medical University of Lodz, Poland, Wróbel Andrzej ,   2nd Chair and Department of Gynecology, Medical University in Lublin, Poland, Surkont Grzegorz ,   Clinic of Operative and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland
Published: February 2025

Aim: The aim of the study was to assess the effect of pelvic floor contraction on urethral mobility and the size of the urogenital hiatus, as well as to compare two ultrasonographic approaches for the assessment of urethral mobility: transperineal with a transabdominal probe and transvestibular with a transvaginal transducer. Materials and methods: Modified Oxford Scale (MOS) was used for clinical evaluation of muscle contraction. The parameters obtained in both ultrasound approaches were assessed for all six Oxford grades. The values of ΔH, ΔD and vector, measured at rest and on pelvic floor muscle contraction, were used to evaluate urethral mobility parameters in both ultrasound methods. Patients with a history of urogynecological surgery, pelvic radiotherapy, significant pelvic prolapse (grade 2 or grater in at least one compartment), as well as those with unilateral or bilateral complete avulsion of the puborectalis muscle were excluded. Results: A total of 272 women were included in the analysis. A statistically significant correlation was found between the contraction force and urethral mobility parameters ΔH and vector-positive and ΔD-negative, obtained in both ultrasound approaches. However, no correlation was demonstrated between the contraction force and changes in the analyzed hiatal parameters. The Bland-Altman analysis showed a high agreement of both measurement methods. Conclusions: The force of pelvic floor muscle contraction, as measured with the Oxford Scale, correlated with urethral mobility in both ultrasound examinations. Assessment of urethral mobility using the three assessed parameters (ΔH, ΔD, vector) allows for the most comprehensive analysis. Only minor differences were found in the analyzed urethral mobility parameters between both ultrasonographic approaches. The impact of pelvic floor muscle contraction on the size of the urogenital hiatus was not confirmed.
The effect of stakeholder type and non-monetary incentive on the propensity to create a budgetary slack – an experimental study among controllers
Authors: Maruszewska Ewa Wanda , Nowak Marta
Published: February 2025

Aim: This study investigated whether the type of stakeholder and the presence of non-monetary incentives affect the controller’s propensity to create budgetary slack and examines the ethical evaluation of budgetary slack creation. Methodology: The authors conducted an experiment among controllers working in Poland. Results: Both incentive and stakeholder types can influence managers’ decision-making about budgetary slack. The ethical evaluation of budgetary slack was affected by the type of stakeholder. Implications and recommendations: A negative ethical evaluation of budgetary slack does not always result in its non-acceptance, especially when the incentive is present and the stakeholder is defined by power, legitimacy, and urgency. Originality/value: Budgetary slack is not widely accepted among Polish controllers, although the needs of production workers serve as ethical justification for creating it. This study expands existing management accounting by incorporating stakeholder issues into the budgetary slack creation problem, as well as contributes to the numerous stakeholder literature, especially to the ‘accounting for stakeholders’ concept.
Nilai-Nilai Dakwah dalam Strategi Komunikasi Pemasaran Kerajinan Aluminium
Authors: Dwi Lestari Ayu , Randicha Hamandia Muhammad , Syarifudin Achmad
Published: February 2025

Aluminum crafts processed into various kitchen utensils are characteristic of Tanjung Atap Village, Tanjung Batu District, Ogan Ilir Regency, South Sumatra. The village’s fame for aluminium crafts has made many people work as aluminium craftsmen, which is used as an economic field for them. In addition to the existence of aluminium craftsmen, some people set up shops to sell kitchen tools, such as the Sakinah Group Aluminium shop. However, in this village, several shops have been established to sell kitchen equipment. This then gave rise to competition for the Sakinah Group Aluminium Shop. The purpose of the study was to determine the marketing communication strategy for aluminium crafts at the Sakinah Group Aluminium Store, the da’wah values applied in marketing communications, and the obstacles to marketing communication strategies for aluminium crafts at the Sakinah Group Aluminium Store. This study uses a qualitative research method that uses descriptive data in the form of written or oral words from what has been studied with data collection techniques, namely observation, interview, and documentation. The results showed that the marketing communication strategy of the Sakinah Group Aluminium figures in Tanjung Atap village used the 4P marketing mix theory (product, price, place, and promotion) in Sakinah Group Store promotional activities using word-of-mouth communication, namely old customers recommending these kitchen tools for cooking to new customers. In addition, Sakinah Group Aluminium uses a shop identification board or banner that functions to provide information to consumers. The da’wah values applied in marketing communications at Sakinah Group Stores include the values of honesty, competition, and serving consumers well. In addition, the obstacle to Sakinah Group Aluminium Store's marketing communication strategy is that it has not yet implemented social media, so the products sold are not widely known by consumers.
Motif Dakwah Multikultural Abdurrahman Wahid Dalam Pendirian Masjid Cheng-ho
Authors: Husnan Moch , Nur Halimatus
Published: February 2025

This study aims to find Abdurrahman Wahid's multicultural da'wah motif approach to Cheng-ho Mosque. Cheng-ho Mosque is a mosque that is quite widely located in Indonesia. This mosque attracts attention because of the combination of architecture and cultural diversity that characterizes it. The focus of the study is to understand the motivation of Multicultural Da'wah behind Abdurrahman Wahid's support for the Cheng-ho mosque. The methods used are qualitative, with a literature analysis approach and a literature study. Conducting this literature review can help avoid repeating research that has been done before and provide in-depth knowledge of Abdurrahman Wahid's thoughts and views on the Cheng-ho mosque. The results show that Abdurrahman Wahid's motives towards the Cheng-ho Mosque are rooted in his beliefs and multicultural approach to spreading Islam. He views the Cheng-ho mosque as a symbol of cultural diversity that can serve as a bridge to strengthen relations between Muslims and non-Muslim communities in Indonesia. Abdurrahman Wahid saw the potential of the Cheng-ho mosque as a place for interfaith dialog, the spread of tolerance values, and the development of social harmony. From the perspective of multicultural da'wah, Abdurrahman Wahid's approach to the Cheng-ho mosque emphasized the importance of inclusion and mutual understanding between religious communities. He promotes the teaching of Islam that is able to appreciate cultural diversity and emphasize the values of interfaith brotherhood. By using the Cheng-ho mosque as a means of da'wah, Abdurrahman Wahid sought to change the paradigm of da'wah from exclusive to inclusive so as to build a more harmonious society.
Eksplorasi Narasi Primordial dalam Harmoni Digital pada Dinamika Multikultural
Authors: Mailin Mailin , Mumtaz al-Mujtahid Nazil
Published: February 2025

Artikel ini bertujuan untuk menganalisis dan mengeksplorasi narasi primordial dalam rangka membentuk harmoni digitial di tengah dinamika multikultural. Bangsa Indonesia adalah bangsa yang heterogen dengan segala jenis kekayaan dan keberagamannya. Sayangnya, munculnya digitalisasi dalam kehidupan masyarakat memunculkan serangkaian problematika baru. Urgensi penelitian ini adalah mengonstruksikan nilai-nilai primordial sebagai instrument harmoni digital di tengah dinamika multikultural. Artikel ini menggunakan penelitian kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data yang digunakan adalah studi pustaka. Data primer dalam penelitian ini adalah artikel terdahulu yang berkenaan dengan tema. Sedangkan data sekunder dalam artikel ini adalah buku-buku dan reportase pendukung. Hasil penelitian menunjukkan bahwa narasi primordial merupakan salah satu upaya preventif dalam menciptakan harmoni digital di tengah multikulturalitas. Adapun beberapa upayanya adalah 1) Pemanfaatan Teknologi untuk Mempertahankan Narasi Primordial Kampanye Pendidikan dan Kesadaran, 2) Kolaborasi Antarbudaya di Media Sosial, 3) Penggunaan Bahasa Digital yang Inklusif, 4) Pengembangan Aplikasi, 5) Berbasis Budayamelestarikan nilai-nilai multikultural dan 6) Pertukaran Seni dan Budaya Digital. Meski demikian, penerapan upaya ini terdapat beragam tantangan sehingga dibutuhkan solusi yang mumpuni dalam menyelesaikannya. Narasi ini dapat diharmonisasikan menggunakan kekuatan media dengan menggunakan konten, kolaborasi antarbudaya dan menciptakan inovasi yang relevan.
Evolving Historiographies
Authors: Hannan Haukil
Published: February 2025

This study explores the distinctions in historical narrative presentation between online platforms and traditional media, focusing specifically on how Islamic history is communicated across various digital outlets. Addressing two pivotal questions, the research first examines how the writing of history on online platforms diverges from conventional media forms. It then investigates the specific strategies employed by these digital platforms—Islamramah.co, Islami.co, Geotimes.id, and Muslim.or.id—to convey Islamic historical narratives to the public. Utilizing content analysis, the study evaluates narrative techniques, visual representations, and interactive elements that digital media integrate to enhance accessibility and engagement. The findings reveal that online platforms offer real-time dissemination, greater global reach, and multimodal content formats, which significantly alter public interaction with historical content. However, these advantages come with challenges, such as the potential for narrative fragmentation, algorithmic influence, and a tendency towards sensationalism. The study concludes that while online platforms facilitate broader access to historical narratives and foster public engagement, they also present risks that can compromise historical accuracy and depth. Thus, the research underscores the need for a balanced approach in digital historical communication.
Representasi Akidah dalam Seni Syiir Tradisional “Blug-Geblug” Chanel Youtube Abi Channel
Authors: Hakim Lukman , Zuhriyah Luluk Fikri
Published: February 2025

Penelitian ini bertujuan untuk mengetahui representasi” akidah dalam Seni Syiir Tradisional Blug-geblug Chanel  Youtube Abi Channel  dan bagaimana proses analisis semiotik Roland Barthes pada Seni Syiir Tradisional Blug-geblug Chanel  Youtube Abi Channel. Jenis penelitian ini merupakan penelitian analisis teks media dengan pendekatan semiotik Roland Barthes. Akidah dalam Seni Syiir Tradisional Blug-geblug mempresentasikan akidah keimanan kepada Allah SWT, Hari akhir, dan qada qadar. Analisis semiotik Roland Barthes pada penelitian ini menghasilkan Tanda berupa Syiir Blug-geblug, Petanda yang terdiri dari salam pembuka, lirik Syiir Blug-geblug dan salam penutup. Denotasi yang berupa Melantunkan Syiir Blug-geblug. Konotasi yang berupa Bersenandung dan Mitos berupa Syiiran Blug-geblug. Peneliti merekomendasikan agar pada penelitian selanjutnya dapat meneliti dan mengkaji lebih dalam dengan menggunakan metode penelitian yang berbeda dengan harapan dapat memiliki nilai kebaruan dalam penelitian tersebut.
Kategori Sosial dan Strategi Penyampaian Pesan Majelis Kopi Nakaya Palangka Raya
Authors: Prasongko Wahyu Agung , Aisyah Siti , Roziqin Muhamad Arif , Andriani Riska Furi
Published: February 2025

Penelitian ini bertujuan untuk menganalisis kategori sosial dan strategi dakwah yang diterapkan di Majelis Kopi Nakaya Palangka Raya, yang merupakan fenomena sosial unik dengan kombinasi aktivitas ngopi dan dakwah. Jenis penelitian ini menggunakan penelitian lapangan (field research) dengan metode kualitatif. Teknik pengumpulan datanya melalui observasi, wawancara, dan dokumentasi. Teknik analisis datanya menggunakan analisis Miles dan Huberman yaitu reduksi data, penyajian data, verifikasi dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa mayoritas jama’ah Majelis Kopi Nakaya di Palangka Raya terdiri dari remaja dan dewasa, yaitu individu berusia 17–35 tahun. Berdasarkan kategori sosial agama, jama’ahnya adalah umat Islam, dengan mayoritas perempuan. Dari segi pendidikan, sebagian besar jama’ahnya merupakan pelajar dan mahasiswa. Kemudian, strategi penyampaian pesan dakwah majelis Kopi Nakaya Palangka Raya ini meliputi pembacaan salawat Nabi, ceramah agama, dan diskusi agama, sehingga menjadikannya ruang yang relevan bagi kelompok usia muda untuk memperdalam pemahaman spiritual dalam suasana yang santai dan inklusif.
Розробка систем охолодження з використанням відновлюваних джерел теплової енергії і технології нічного радіаційного випромінювання
Authors: Тітлов О.С. , Цой О.П. , Ашик Т.А. , Алімкешова А.Х. , Джамашева Р.А.
Published: February 2025

Останнім часом, у зв’язку з вимогами енергоефективності та скороченням терміну використання синтетичних холодоагентів у холодильних системах, спостерігається стійкий інтерес до пасивних методів охолодження. Одним із таких методів є охолодження за рахунок радіаційного випромінювання в космічний простір. У статті показані енергетичні перспективи використання технології «нічного радіаційного охолодження» (НРО) для автономних систем охолодження переважно в сільських і фермерських господарствах. Використання НРО в значній мірі визначається особливостями клімату того чи іншого регіону. У певних кліматичних умовах холодильні системи, що використовують радіаційне випромінювання, будуть працювати ефективніше, ніж в інших. Із усього спектра сучасного холодильного обладнання для вирішення завдань автономного штучного охолодження найбільш ефективними з енергетичної точки зору є парокомпресійні холодильні машини, що працюють від дизель-генераторів або сонячних батарей, а також тепловикористальні абсорбційні холодильні машини, джерелом теплової енергії для яких є потоки нагрітих газів і рідин. Розроблено алгоритм пошуку мінімальної температури джерела, що гріє, в залежності від температур об'єкта охолодження і охолоджуючого середовища абсорбційної водоаміачної холодильної машини (АВХМ). Показано, що при реалізації традиційних циклів АВХМ є режими з максимальною енергетичною ефективністю в практичному діапазоні температур, а для їх досягнення необхідно відповідна комбінація складу робочого тіла і температур гріючого джерела. Показано переваги при ПКХМ при низьких температурах атмосферного повітря. Як робоче тіло для цих умов рекомендований аміак, з максимальною енергетичною ефективністю холодильного циклу серед розглянутих аналогів. Розроблено оригінальні схеми автономних систем охолодження молока на базі ПКХМ і АВХМ з використанням технології НРО
Assets and sources of income of municipal councillors in Poland – analysis of asset declarations against the risk of corruption
Authors:   Nicolaus Copernicus University in Toruń, Czyżniewski Marcin
Published: February 2025

Municipal councillors in Poland are required to submit annual asset declarations. It’s a part of the transparency of public life, declarations make it possible to determine whether a councillor’s assets are justified by his or her income and whether the income itself comes from legal and ethical sources. This article analyses 1,500 asset declarations submitted in 2024 to determine whether general conclusions can be drawn from publicly available declarations indicating corrupt situations or the risk of such situations. The subject of the analysis is whether the assets of municipal councillors in Poland are clearly higher than average, whether councillors derive income from sources that may indicate a conflict of interest or corruption, including political corruption, whether councillors have above-average financial liabilities, including with individuals? The asset declarations examined indicate the existence of risks of corrupt situations, but their analysis does not show them to be of wider scope. On its basis, it is not possible to advance the thesis that holding a mandate as a municipal councillor in Poland is associated with income that could be considered suspicious, nor with above-average assets.
Manifestations of corruption in local government elections in Albania. Implications for the process of its accession to the European Union
Authors:   University of Szczecin, Podgórzańska Renata
Published: February 2025

One of the key values on which the European Union is based is the rule of law that also includes efficient mechanisms for counteracting and combating corruption. What is more, it is a key condition for countries aspiring to membership in the European Union. An example here comes from Albania’s accession aspirations. Their progress is determined by the dynamic changes in the transformation processes of this country, including progress in counteracting and eliminating corruption in the political and economic space. Explanation of the specific characteristics of Albanian reality and the exegesis of the impact of corruption on the process of the country’s closer EU cooperation are the aims of the research taken up here. Special focus will be given to electoral corruption in local government elections that took place on 14 May 2023. At the same time, these elections are only a background to a broader discussion on the essence of corruption in the Albanian reality as a factor that determines its accession process.
Corrupt behavior and the safety of organizational units of the Prison Service
Authors:   Olsztyn Detention Center, Jaroszewska Marta
Published: February 2025

Corruption in a broad, general sense is perceived as an important social problem that occurs in all spheres of human activity. This phenomenon develops according to the dynamics of changes in a given society. What remains unchanged over the years is that the purpose of corruption is material goods and personal benefits. The subject of this article is the phenomenon of corruption occurring in penitentiary units in the context of their security. When considering the issue of corruption, particular attention should be paid to the judicial authorities and places where perpetrators of crimes, including persons convicted for bribery, are serving sentences, i.e. prisons or detention centers.
Possible erythropoietin pharmacotherapeutic targets on painful diabetic neuropathy in rats
Authors: SUAREZ-MENDEZ SAMUEL , BERMÚDEZ-OCAÑA DEYSI Y.
Published: February 2025

Abstract Erythropoietin is a renal cytokine involved in regulating hematopoiesis. Current evidence indicates that erythropoietin exerts pleiotropic effects in animal models. However, its role in painful diabetic neuropathy, as well as the possible action mechanisms are not yet established. Therefore, this was the purpose of our study. Rats were injected with streptozotocin to produce hyperglycemia. The mechanical allodynia was measured by the up-down method using the von Frey filaments in diabetic rats. To determine the action mechanisms of erythropoietin, levels of NF-κB in serum were measured with ELISA and was used L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride, non-selective nitric oxide synthase inhibitor; 0.1-1 mg/kg, i.p.), glibenclamide (ATP-sensitive K+ channels blocker; 1-10 mg/kg, i.p.), methiothepin (non-selective 5-HT receptor antagonist; 0.01-0.1 mg/kg, i.p.) and naloxone (non-selective opioid receptor antagonist; 1 mg/kg). Intraperitoneal administration of erythropoietin (500-4000 UI/kg) prevented allodynia in diabetic rats. Additionally, erythropoietin significantly decreased serum levels of NF-κB during the evaluation of tactile allodynia and L-NAME, glibenclamide and methiothepin, but not naloxone, reverted erythropoietin-induced antiallodynia. These data suggest erythropoietin effect on painful diabetic neuropathy are mediated at least in part, via deactivation of NF-κB, activation of nitric oxide-ATP-sensitive K+ channel pathway as well as the activation of 5-HT receptors.
EDUCAÇÃO PARA A CIDADANIA: A BASE NACIONAL COMUM CURRICULAR PODE CONTRIBUIR?
Authors: BURGOS MARCELO BAUMANN
Published: February 2025

RESUMO: Em tempos de ataques à democracia, a educação para a cidadania adquire renovada importância. Mas ela não é um produto espontâneo da escolarização, pressupondo o desenvolvimento de determinadas atitudes estudantis que, conforme argumentamos, exigem da escola uma articulação entre as dimensões pedagógica e organizacional. No Brasil, as políticas voltadas para esse fim ainda são incipientes, mas a partir de pesquisa nacional, recentemente realizada pelo Centro de Políticas Públicas e Avaliação da Educação da Universidade Federal de Juiz de Fora, sobre a implementação da Base Nacional Comum Curricular na Educação Infantil e no Ensino Fundamental, vislumbramos um potencial interessante nessa política, que precisa ser reconhecido e valorizado. Para melhor refletir sobre essa hipótese, formulamos um modelo de análise que permite uma abordagem mais sistemática das variáveis fundamentais para a educação para a cidadania. Com isso, voltamos aos dados da referida pesquisa e chegamos à conclusão de que a Base tem potencial para contribuir para o fortalecimento da educação para a cidadania, sobretudo se for concebida em um contexto de plena participação dos atores diretamente envolvidos com a educação e a comunidade escolar, o que não foi o caso da versão aprovada pelo Conselho Nacional de Educação no conturbado ambiente político de 2017.
FROM ONCOLOGIST TO SURGEON - GENETICS IN COLORECTAL METASTASIS FOR SURGEONS
Authors: SILVA Marília Polo Mingueti e , SABBAGA Jorge , NAJMAN Henry Luiz , NASCIMENTO Carlos David Carvalho , COTTA-PEREIRA Ricardo Lemos , NICOLUZZI João Eduardo Leal , BRAGHIROLI Maria Ignez
Published: February 2025

ABSTRACT Colorectal cancer (CRC) is a common disease, with incidence in Brazil of 45,630 new cases per 100,000 inhabitants between 2023-2025. Risk factors for CRC can be evaluated between environmental and hereditary and their mode of presentation are classified as sporadic, inherited and familial. Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. Sporadic disease is characterized by the absence of a family history and accounts for approximately 70% of all colorectal cancers, being more common over 50 years of age, with dietary and environmental factors implicated in its pathogenesis. The percentage of patients with a true hereditary genetic predisposition is less than 10%, and these are related to the presence or absence of colonic polyps as an important manifestation of the disease. Non-polyposis diseases are known as hereditary non-polypomatous colorectal cancer (HNPCC) or Lynch syndrome, and polyposis diseases are familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and hamartomatous polyposis syndromes (e.g., Peutz-Jeghers, juvenile polyposis, phosphatase and tensin homologue - PTEN, Cowden syndrome). These diseases are linked to a high risk of developing cancer. With the development of treatments in metastatic disease and the use of targeted therapies and their biomarkers, it was possible to evaluate them within clinical studies both in the primary tumor and in the correspondence of metastases.
Barreiras e facilitadores para adesão à farmacoterapia em doenças crônicas: uma revisão de escopo
Authors: Gonçalves Ana Maria Rosa Freato , Campos Marília Silveira Almeida , Menezes Lara Almeida de , Pereira Leonardo Régis Leira
Published: February 2025

Resumo Para nortear as intervenções dos profissionais de saúde é preciso identificar as razões para a não adesão ao tratamento. Essa revisão de escopo objetiva identificar e discutir acerca das barreiras e facilitadores para a adesão à farmacoterapia em doenças crônicas. Dos 3.482 estudos elegíveis, observou-se nos 114 estudos que atenderam aos critérios de seleção facilitadores como renda, suporte social, maior idade, escolaridade, motivação para utilizar a farmacoterapia, formação de vínculo com o profissional de saúde; educação em saúde; acreditar na farmacoterapia; perceber os benefícios da farmacoterapia; motivação para o autocuidado e severidade da doença; foram comuns às diversas condições crônicas de saúde, bem como as barreiras: custo com o medicamento, complexidade da farmacoterapia; Reação Adversa ao Medicamento; maior número de prescritores e farmácias utilizadas; maior idas aos serviços de urgência e emergências; acreditar que o medicamento não é necessário e ter depressão. A análise desses fatores fornece subsídios para o profissional de saúde identificar os motivos que levaram a não adesão e nortear as intervenções a serem realizadas, promovendo a adesão ao tratamento.
Facebook users’ engagement with dental caries misinformation in Brazilian Portuguese
Authors: Remiro Mariana , Jorge Olívia Santana , Lotto Matheus , Oliveira Thaís Marchini , Machado Maria Aparecida Andrade Moreira , Cruvinel Thiago
Published: February 2025

Abstract This study analyzed dental caries-related Facebook posts in Brazilian Portuguese to identify misinformation and predict user interaction factors. A sample of 500 posts (between August 2016 and August 2021), was obtained by CrowdTangle. Two independent and calibrated investigators (intraclass correlation coefficient varying from 0.80 to 0.98) characterized the posts based on their time of publication, author’s profile, sentiment, aim of content, motivation, and facticity. Most posts (90.2%) originated from Brazil, and they were predominantly shared by business profiles (94.2%). Approximately 67.2% of these posts focused on preventive dental issues, driven by noncommercial interests in 88.8% of cases. Misinformation was present in 39.6% of the posts, particularly those with a positive sentiment and commercial motivation. Business profiles and positive sentiment were identified as predictive factors for higher post engagement. These findings highlight a significant proportion of dental caries-related posts containing misinformation, especially when associated with positive emotions and commercial motivation.
Implications of physical and psychological alterations on Civil Police officers’ quality of life
Authors: Tavares Juliana Petri , Paixão Miguel Lucas Silva da , Vieira Lizandra Santos , Gonçalves Gabriel Fernandes , Pai Daiane Dal , Machado Wagner de Lara
Published: February 2025

Abstract To assess the relationship of physical and psychological changes with quality of life in Civil Police officers from Porto Alegre. Cross-sectional study carried out with 237 workers in Porto Alegre, Brazil. The physical and psychological changes were evaluated by means of the Standardised Nordic Questionnaire, Self-Reporting Questionnaire, Maslach Burnout Inventory, and Effort-Reward Imbalance instruments. Quality of life was assessed using the World Health Organization Quality of Life tool. Of all 237 Police officers, 51.9% were men with a mean age of 41.4 years old (± 8.58), and they had been active in the function for 6 (3-14) years. The minor psychiatric disorders (MPD) were positively influenced by musculoskeletal symptoms and by burnout, and exerted a negative influence on the QoL Physical domain. The QoL was negatively influenced by musculoskeletal symptoms, by MPDs and by stress. The QoL Environment domain presented an inverse relationship with stress, which was intensified by burnout. Physical and psychological changes affect Police officers’ QoL, impacting on the health system.
Home office is associated with weight gain during the COVID-19 pandemic: Brazilian population-based studies
Authors: Meller Fernanda de Oliveira , Schäfer Antônio Augusto , Vargas Bianca Languer , Viero Vanise dos Santos Ferreira , Saes-Silva Elizabet , Quadra Micaela Rabelo , Dumith Samuel de Carvalho
Published: February 2025

Abstract The COVID-19 pandemic caused changes in life, affecting habits and behaviors, and one of its consequences is an increase in weight. We aimed to evaluate the association between remote work and weight gain during the COVID-19 pandemic in two cities in southern Brazil. A population-based cross-sectional study carried out in the southern region of Brazil. Data were collected face-to-face, in households selected by census sampling. The outcome was weight gain, and the exposure was remote working. To verify this association, Poisson Regression was used to calculate the crude and adjusted prevalence ratio and its 95% confidence intervals, using 5% significance level. In total, 2,152 individuals were interviewed. The prevalence of weight gain during the pandemic was 38.4% (95%CI 36.1-40.7), being significantly higher in those who worked remotely (47.0% vs 37.7, p=0.02). Those individuals who worked remotely were 23% more likely to gain weight during the pandemic compared to those who did not work remotely (PR: 1.23; 95%CI 1.02-1.49). Health and education services may be encouraged to implement educational actions at the collective level, aimed at enlightening the population and preventing weight gain in periods of confinement.
Métodos de avaliação da síndrome da fragilidade em pessoas idosas com diabetes: uma revisão integrativa
Authors: Batista Thaysa de Aguiar , Lima Isabelle Karine Ramos de , Arruda Ilma Kruze Grande de , Borba Anna Karla de Oliveira Tito
Published: February 2025

Resumo O estudo objetiva sintetizar o conhecimento disponível sobre os métodos utilizados para avaliação da síndrome da fragilidade em pessoas idosas com diabetes na comunidade. Trata-se de uma revisão integrativa da literatura feita nas bases de dados LILACS, PubMed, Embase, Web of Science e Scopus. Foram incluídos 19 artigos categorizados com base nos tipos de instrumentos: unidimensional, que incluem apenas os elementos físicos da fragilidade, e o multidimensional, que incorpora os domínios cognitivos e psicossociais. Constatou-se a presença de fragilidade em todos os artigos incluídos, havendo uma variação de 28,2% a 80% para os instrumentos unidimensionais e de 9,4% a 46,2% para os multidimensionais. As evidências científicas demonstraram que há uma distinção clara entre os vários instrumentos analisados e, conforme a realidade a ser aplicada, os pontos de corte dos itens que compõem as escalas de fragilidade devem ser adaptados para a população de estudo. Diante disso, é necessária a realização de novos estudos para investigar métodos mais simples para a identificação da síndrome de fragilidade, a fim de facilitar seu uso na atenção primária de saúde, ajudando a identificar precocemente o risco de desenvolver a fragilidade.
As representações sociais da COVID-19 dos usuários dos serviços da atenção primária no contexto da pandemia
Authors: Shimizu Helena Eri , Sousa Yuri Sá Oliveira , Apostolidis Thémis
Published: February 2025

Resumo O estudo teve como objetivos identificar e analisar as representações sociais dos usuários da atenção primária do SUS do Distrito Federal acerca da COVID-19 no contexto da pandemia. Estudo qualitativo fundamentado na teoria das representações sociais (TRS) que analisou 1.713 entrevistas com usuários no software Iramuteq. O procedimento de classificação hierárquica descendente (CHD) distribuiu 85,79% dos conjuntos de palavras associadas à COVID-19 em cinco classes lexicais. São as principais representações da pandemia de COVID-19 dos usuários da APS do DF: medo e morte. A falta de coordenação do sistema de saúde, que requeria governança pelo Estado, dificultou que a assistência às pessoas chegasse a tempo oportuno. Os segmentos sociais historicamente excluídos, particularmente a população preta e parda, e economicamente vulnerável, vivenciaram de forma mais contundente diversas perdas, inclusive de vidas. A superação do conflito entre um Estado austero e mínimo, como a que prevaleceu no momento da pandemia, e a premência de construção de um sistema de saúde solidarista, em uma sociedade com grandes diferenças socioeconômicas, mantém no centro do debate da bioética de Intervenção a necessidade se avançar na garantia da saúde no pós-COVID-19.
Sobre a Farma e a Big Pharma
Authors: Guimarães Reinaldo
Published: February 2025

Resumo O texto discute a trajetória da indústria farmacêutica global na direção de tornar-se o que se denomina atualmente de Big Pharma. Apresenta a configuração do Complexo Industrial da Saúde e expõe suas dimensões econômicas e políticas. Sugere como determinantes essenciais da transformação da indústria farmacêutica global na Big Pharma o processo de financeirização da economia política mundial e a harmonização do regime de propriedade intelectual realizado pela Organização Mundial do Comércio através do acordo TRIPS. Além disso discute as mudanças microeconômicas ocorridas no processo produtivo das empresas. Finalmente aponta que essa trajetória se inscreve no processo de fragilização da representação multilateral construída no pós Segunda Guerra Mundial durante a década de 1990.
Uso de dietas especiais no Brasil: II Inquérito Nacional de Alimentação 2017-2018
Authors: Bortolot Beatriz Salari , Araujo Marina Campos , Verly Junior Eliseu
Published: February 2025

Resumo O objetivo do presente estudo foi estimar a prevalência do uso de dietas especiais e analisar o perfil sociodemográfico, o estado nutricional e uso de sal, açúcar e adoçantes em brasileiros que realizam dietas especiais. Trata-se de um estudo transversal utilizando dados do segundo Inquérito Nacional de Alimentação 2017/2018 (n=45.689 indivíduos com pelo menos 10 anos de idade). Foi questionado o uso de dietas para hipertensão, diabetes, colesterol, doença do coração e para emagrecer. Foi estimada a prevalência do uso de dietas de acordo com características sociodemográficas e estado nutricional, e modelos de regressão logística foram utilizados para avaliar os fatores associados à realização de dietas. Todas as análises consideraram o desenho da amostra e os fatores de expansão. A prevalência do uso de dietas especiais foi de 14,3%, sendo as dietas para emagrecer (5,2%) e pressão alta (4,6%) as mais prevalentes. As mulheres, idosos, indivíduos de maior renda e com obesidade tiveram maiores chances de realizarem qualquer tipo de dieta especial quando comparados aos seus pares.
Material- based approaches for efficient forecasting and mitigation of air pollution using advanced neural network models
Authors: Mylan Jamuna , Arunachalam Gandhimathi
Published: February 2025

ABSTRACT Air pollution is a critical environmental problem driven by urbanization and industrialization. Time-series forecasting using previous methods is difficult because models must account for seasonal changes, day-to-day changes, and emergencies that can rapidly affect air quality. Therefore, existing approaches struggle to predict these fluctuations. This research addresses this issue by proposing a material-focused method of air quality prediction using machine learning techniques. The proposed model incorporates feature selection using MS-ANFIS-FS and classification using Unet-RNN (Unet Optimized Recurrent Neural Network). The model focuses on analyzing pollutant interactions with material surfaces, improving prediction accuracy by considering the role of materials in pollutant dispersion and absorption. The Successive Feature Defect Scaling Rate (SFDSR) and Auto-Regressive Integrated Moving Average (ARIMA) methods detect variance dependencies in air quality data. These methods enable the model to identify material traits influencing pollution levels, yielding more accurate results for pollutants like PM2.5 and NO2. The findings demonstrate the critical importance of material properties in environmental management and show how material-based interventions can effectively reduce air pollution. This model has the potential to facilitate real-time pollution monitoring and support the development of sustainable air quality management strategies.
Multi-attribute recursive optimization (MARO) for EDM of D3 tool steel
Authors: Rajasekaran Rekha , Venukrishnan Rajesh Pinnavasal , Neelakandan Baskar , Muthukrishnan Varatharajulu
Published: February 2025

ABSTRACT Electric Discharge Machining (EDM) is one of the most effective unconventional material removal techniques that mill electrically conductive objects, despite their hardness using electrical discharge. This elite method provides excellent accuracy and surface finish within short duration. The presented research envisages to study the effect of process variables of EDM namely Pulsating Current (I), Pulse-on-time (Ton) and Pulse-off time (Toff) on machining performance measures namely Tool Wear Rate (TWR), Surface Roughness (SR) and Material Removal Rate (MRR). The best possible condition for specimen selection is presented by a new technique known as Multi Attribute Recursive Optimization (MARO). The optimal experimental conditions were found with Ton 100 s, Toff 49.82 s, and I 4.99 A, with ideal responses of SR 0.057 µm, MRR 0.036 g/min, and TWR 3.301 g/min. For the best run identification, the METHod for Enrichment Evaluation, Preference Ranking Organization METHod (PROME-THEE) was used while Historical Data Design (HDD) was used to validate the result obtained. The integration of PROMETHEE and HDD known as MARO is identified to appreciate degree of the methods analyzed. The close convergence of PROMETHEE and HDD at 97% guarantees the accuracy of the proposed MARO technique.
Socioeconomic profile and environmental perception of Amazon beach users about solid waste
Authors: Amazonas M. G. , Araújo M. L. G. , Yamamoto K. C. , Soares N. N. , Matos O. F. , Aguiar-Santos J. , Ribeiro-Brasil D. , Oliveira A. T.
Published: February 2025

Abstract Studies on environmental perception can contribute to managing solid waste on beaches, as they elucidate the nuances of the interaction between humans and the environment, highlighting the necessary transformations aligned with user preferences. The objective was to determine the socioeconomic profile of users and identify these actors environmental perceptions of solid waste of bathers on the beaches of Rio Negro and identify their environmental perception about the incorrect disposal of solid waste in these environments. Interviews were conducted on Ponta Negra, Lua, Tupé and Paricatuba beaches. Women predominated on Ponta Negra and Lua beaches, and men on Paricatuba and Tupé. On the Tupé and Lua beaches, people between 31 and 40 years old stood out. The majority (70%) responded that they completed high school and received up to two minimum wages. Users frequent Ponta Negra beach during the high-water season and the naturally formed beaches in the low waters of the Rio Negro. Most seek out beaches as leisure and consider cleanliness an essential factor. More than 80% stated that they do not leave trash on the beach, in practice, this information was not observed. Plastic was the main item reported. We evidenced that users have little awareness regarding environmental education on Amazon beaches and that educational actions must be carried out.
Consenso Brasileiro de Lipedema pela metodologia Delphi
Authors: Amato Alexandre Campos Moraes , Peclat Ana Paula Rolim Maia , Kikuchi Rodrigo , Souza Antonio Carlos de , Silva Mariana Thalyta Bertolin , Oliveira Roney Hans Prager de , Benitti Daniel Augusto , Oliveira Julio Cesar Peclat de
Published: February 2025

Resumo O lipedema, historicamente sub-reconhecido, tem ganhado destaque devido aos avanços na pesquisa e ao aumento da conscientização. O Consenso Brasileiro de Lipedema, promovido pela Sociedade Brasileira de Angiologia e de Cirurgia Vascular, visa estabelecer diretrizes claras para diagnóstico, tratamento e manejo. Utilizando a metodologia Delphi, o estudo envolveu a criação de 90 afirmações sobre lipedema por especialistas, seguida pela avaliação de 113 profissionais adicionais. Essas afirmações foram analisadas via SurveyMonkey, com um limiar de 75% de concordância necessário para sua inclusão no consenso. A maioria das afirmações atingiu um consenso significativo, exceto nove, que precisam de mais pesquisa. O estudo enfatiza a complexidade do lipedema, a eficácia do tratamento conservador sobre a cirurgia, a necessidade de abordagens multidisciplinares e a importância da conscientização para reduzir o subdiagnóstico e o estigma. Ressalta-se também a contínua necessidade de pesquisas para desenvolver estratégias de manejo mais efetivas.
Brazilian Consensus Statement on Lipedema using the Delphi methodology
Authors: Amato Alexandre Campos Moraes , Peclat Ana Paula Rolim Maia , Kikuchi Rodrigo , Souza Antonio Carlos de , Silva Mariana Thalyta Bertolin , Oliveira Roney Hans Prager de , Benitti Daniel Augusto , Oliveira Julio Cesar Peclat de
Published: February 2025

Abstract Lipedema, historically underrecognized, has recently gained attention due to advancements in research and growing public awareness. The Brazilian Consensus Statement on Lipedema, developed by the Brazilian Society of Angiology and Vascular Surgery, aims to establish clear recommendations for the diagnosis, treatment, and management of lipedema. Using the Delphi methodology, experts elaborated 90 statements about lipedema, which were then evaluated by a panel of 113 professionals. The statements were analyzed using SurveyMonkey, with a 75% agreement threshold required for their inclusion in the consensus statement. Most statements achieved significant consensus, with only 9 topics requiring further investigation. This consensus statement highlights the complexity of lipedema, the effectiveness of conservative treatment over surgery, the need for multidisciplinary approaches, and the importance of awareness to reduce underdiagnosis and stigma. It also underscores the ongoing need for research to develop more effective management strategies.
Modulatory Impacts of Probiotic on the Synthesis of Claudins and Mucins in the Gastrointestinal Tract of Broiler Chicks
Authors: Mohammed ESI , Al-Rasheed M , Ahmed MS
Published: February 2025

ABSTRACT This study investigated the effect of 3 strains of probiotic bacteria on mRNA synthesis of some claudins (claudins1(CLD1), CLD3, and CLD5), and mucins (MUC5AC and MUC2) in broilers’ digestive systems. Chicks were assigned to one of three groups: a control group receiving no probiotics, and two experimental groups receiving starter rations with 0.2% and 0.4% probiotics (mixture of Streptococcus faecalis, Clostridium buthricum, and Bacillus mesentericus) over a 14-days period. Proventriculi, ilea, ceca, and cola samples were collected at days 0, 7, and 14 (D0, D7 and D14) for gene expression analysis. Results revealed that CLD1 expression was lower in probiotic groups at D0 and D14 in the proventriculus and colon, respectively, yet higher at D7 in the ileum and colon. In probiotic-fed chicks, CLD5 mRNA synthesis was downregulated at D14 in all segments, except for the proventriculus; and it was upregulated at D7 in colon, and at D14 in the proventriculus. MUC5AC expression was elevated at D7 in the proventriculus and D14 in the ileum with probiotic feeding, whereas MUC2 was significantly downregulated at D14 in the ileum. These findings suggest a protective role of probiotic against pathogenic stimuli affecting the synthesis of claudins and mucins in the gastrointestinal tract of broilers, potentially enhancing intestinal barrier function and resilience against pathogenic challenges.