bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Solvent‐Free Microwave‐Assisted ortho‐Alkylation of Aromatic Ketimine with Acrylic Acid Derivatives by Rh(I) Catalyst.
Authors: Jo Eun‐Ae , Ahn Jeong‐Ae , Jun Chul‐Ho
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Manganese‐ or Iron‐Catalyzed Homocoupling of Grignard Reagents Using Atmospheric Oxygen as an Oxidant.
Authors: Cahiez Gerard , Moyeux Alban , Buendia Julien , Duplais Christophe
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Esterification of Carboxylic Acids and Diacids by Trialkyl Borate under Solvent‐ and Catalyst‐Free Conditions.
Authors: Mansoori Yagoub , Tataroglu Seyidov Firdovsi , Bohlooli Shahrbanoo , Zamanloo Mohammad Reza , Imanzadeh Gholam Hassan
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Cascade Processes on Group 6 Fischer‐Type Carbene Complexes: Cyclopropanation and Metathesis Reactions.
Authors: Barluenga Jose , Andina Facundo , Aznar Fernando , Valdes Carlos
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselecitve Iridium‐Catalyzed Allylic Amination of Ammonia and Convenient Ammonia Surrogates.
Authors: Pouy Mark J. , Leitner Andreas , Weix Daniel J. , Ueno Satoshi , Hartwig John F.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aza‐Henry Reaction of Ketimines Catalyzed by Guanidine and Phosphazene Bases.
Authors: Pahadi Nirmal K. , Ube Hitoshi , Terada Masahiro
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile and Efficient anti‐Selective Four‐Component Direct Aldol Addition via Chemoselective Thioester Enolate Formation.
Authors: Zhou Guoqiang , Yost Julianne M. , Sauer Scott J. , Coltart Don M.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A One‐Pot Silyl‐Reformatsky Olefination.
Authors: Smith James M. , Greaney Michael F.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Water‐Solubility, Antioxidant Activity and Cytochrome C Binding of Four Families of Exohedral Adducts of C60 and C70.
Authors: Witte Patrick , Beuerle Florian , Hartnagel Uwe , Lebovitz Russell , Savouchkina Anastasia , Sali Sevda , Guldi Dirk , Chronakis Nikos , Hirsch Andreas
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and anti‐Staphylococcal Activity of New Halogenated Pyrroles Related to Pyrrolomycins F.
Authors: Raimondi Maria Valeria , Schillaci Domenico , Petruso Salvatore
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recoverable (R)‐ and (S)‐Binap—Ag(I) Complexes for the Enantioselective 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides.
Authors: Najera Carmen , Retamosa M. de Gracia , Sansano Jose M.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Synthesis of Maleimides and Carbazoles via Zn(OTf)2‐Catalyzed Tandem Annulations of Isonitriles and Allenic Esters.
Authors: Li Yuanzhen , Zou Haixia , Gong Jianxian , Xiang Jing , Luo Tuoping , Quan Junmin , Wang Guoxin , Yang Zhen
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Au(I)‐Catalyzed Enantioselective 1,3‐Dipolar Cycloadditions of Muenchnones with Electron‐Deficient Alkenes.
Authors: Melhado Asa D. , Luparia Marco , Toste F. Dean
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Azabicyclo[3.1.0]hexane‐1‐ols as Framework for the Asymmetric Synthesis of Biologically Active Compounds.
Authors: Jida Mouhamad , Guillot Regis , Ollivier Jean
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthetic Route to 2‐Alkylpropane‐1,3‐sultones and Its Application to the Synthesis of 2‐Alkyl Derivatives of Tramiprosate.
Authors: Bachand Benoit , Atfani Mohamed , Samim Bita , Levesque Sophie , Simard Daniel , Kong Xianqi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Oxidation and Dehydrogenation of Cyclic N,O‐ and N,S‐Acetals. Part 3. [1,2] Transformation of N,O‐Acetals: 3‐Acyl‐1,3,4‐oxadiazolines.
Authors: Somogyi Laszlo
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Chemistry of N‐Arylated Pyrano[2,3‐c]pyrazoles.
Authors: Samaritoni J. Geno , Thornburgh Scott , Graupner Paul R. , Cooper David H.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multicomponent Radical Processes: Synthesis of Substituted Piperidinones.
Authors: Godineau Edouard , Landais Yannick
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Activation of the Leaving Group in the SN2 Reaction.
Authors: Yamamoto Hirofumi , Pandey Ghanshyam , Asai Yumiko , Nakano Mayo , Kinoshita Atsushi , Namba Kosuke , Imagawa Hiroshi , Nishizawa Mugio
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4‐Amino‐5,6,7,8‐tetrahydrothieno[2,3‐b]quinolin‐5‐ol Derivatives (V).
Authors: Song Yang‐Heon , Seo Jinmoo
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Alternate Approach for the Synthesis of 2‐Substituted‐arylimidazo[4,5‐b]pyridines and Their anti‐Bacterial Activity.
Authors: Vinodkumar Ramanatham , Chari Murugulla Adharvana , Dubey Pramod Kumar
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cycloaddition of 2‐Acylmethyl‐1H‐benzimidazoles to 4‐Arylidene‐1,3‐oxazol‐5‐ones.
Authors: Dzvinchuk I. B. , Lozinskii M. O.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Condensed Isoquinolines. Part 23. Reaction of o‐Bromomethylphenylacetonitrile with Anthranilic Acids: Synthesis of 6H,12H,17H‐Dibenzo[3,4:6,7][1,8]naphthyridino [1,8‐ab]quinazoline‐6,17‐diones (III).
Authors: Potikha L. M. , Kovtunenko V. A. , Turov A. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Aroylthioureas with Acetylenic Esters and Dibenzoyl Ethylene. Selectivity Towards the Formation of New 1,3‐Thiazines.
Authors: Aly Ashraf A. , Ahmed Essam K. , El‐Mokadam Khalad M.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Methyl 2‐Amino‐3H‐1‐benzazepine‐4‐carboxylates and 2‐(Cyanomethyl)‐2,3‐dihydro‐1H‐indole‐2‐carboxylates from Morita—Baylis—Hillman Acetates of 2‐(Acylamino)benzaldehydes.
Authors: Lim Hee Nam , Song Young Seok , Lee Kee‐Jung
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of New Tricyclic Spirobispidines via Ring Closing Metathesis Reaction.
Authors: Hametner Christian , Dangl Daniel , Mereiter Kurt , Marchetti Martina , Froehlich Johannes
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Functionalized Dithia‐12(13)‐crown‐4 Ethers: Synthesis, Complex Formation, and Extraction Capacity.
Authors: Zenina A. A. , Rakhmanov E. V. , Bobyleva A. A. , Lukovskaya E. V. , Kuzmina L. G. , Abramov A. A. , Anisimov A. V.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple, General, and Efficient Synthesis of Meso‐Substituted Borondipyrromethenes from a Single Platform.
Authors: Pena‐Cabrera Eduardo , Aguilar‐Aguilar Angelica , Gonzalez‐Dominguez Martha , Lager Erik , Zamudio‐Vazquez Rubi , Godoy‐Vargas Jazmin , Villanueva‐Garcia Fabian
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 1‐Cyclopropylallenes with Phenylselenyl Bromide: A Highly Efficient and Stereoselective Method for the Preparation of 2‐Phenylselenyl‐6‐bromo‐1,3‐hexadienes.
Authors: Yu Lei , Meng Bo , Huang Xian
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Pomolic Acid Triterpene Glycosides from Zygophyllum eichwaldii
Authors: Sasmakov S. A. , Putieva Zh. M. , Lindequist U.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sodium Dithionite Initiated Addition of CF2Br2 to β‐Pinene and Reactions of the Adduct. Synthesis and the Reactivity of New 1,1‐Difluorodienes.
Authors: Dmowski Wojciech , Jalmuzna Anna , Urbanczyk‐Lipkowska Z.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Synthesis of (.+‐.)‐Harmacine (IIIa) and (.+‐.)1,2,3,4,6,7,12,12b‐Octahydroindole[2,3‐a]quinazoline (IIIb)
Authors: King Frank D.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Iejimalide B. An Application of the Shiina Macrolactonization.
Authors: Schweitzer Dirk , Kane John J. , Strand Daniel , McHenry Peter , Tenniswood Martin , Helquist Paul
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Approach for the Conversion of Natural Δ3 Cephalosporin Derivatives into Corresponding Δ2 Cephalosporin Derivatives
Authors: Rao Korrapati V. V. , Dandala Ramesh , Handa Vijay K. , Kamat Anand. G. , Rao Inti. V. Subramanyeswara , Rani Ananta , Naidu Andra
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: General Synthesis Route to Benanomicin‐Pradimicin Antibiotics
Authors: Tamiya Minoru , Ohmori Ken , Kitamura Mitsuru , Kato Hirohisa , Arai Tadamasa , Oorui Mami , Suzuki Keisuke
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis and Cytotoxicity of a Cancer Chemopreventive Naphthoquinone from Tabebuia avellanedae.
Authors: Yamashita Mitsuaki , Kaneko Masafumi , Iida Akira , Tokuda Harukuni , Nishimura Katsumi
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Magnetic Sensing Approach to Characterize Corrosion in Reinforced Concrete
Authors: Popovics John S. , Gallo Gonzalo E. , Shelton Melanie , Chapman Patrick L.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Precious Metal Catalysts Supported on Ceramic and Metal Monolithic Structures for the Hydrogen Economy
Authors: Farrauto Robert J. , Liu Ye , Ruettinger Wolfgang , Ilinich Oleg , Shore Larry , Giroux Tom
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel S‐Ribosylhomocysteine Analogues as Potential Inhibitors of Luxs Enzyme
Authors: Wnuk Stanislaw F. , Lalama Jennifer , Robert Jenay , Garmendia Craig A.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Family of Inhibitors of Mycobacterium tuberculosis Thymidine Monophosphate Kinase.
Authors: Gasse C. , Huteau V. , Douguet D. , Munier‐Lehmann H. , Pochet S.
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and anti‐HSV Activity of New N1‐Acyclic C4 and C6‐Disubstituted Pyrazolo[3,4‐d]pyrimidine Nucleosides
Authors: Moukha‐chafiq Omar , Taha Mohamed Labd , Mouna Abdelmalek
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Systems Biology of Antibiotic Production by Microorganisms
Authors: Rokem J. Stefan , Lantz Anna Eliasson , Nielsen Jens
Published: February 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Untersuchungen zur Herstellung von nanoskaligem Bariumsulfat
Authors: Petrova A. , Hintz W. , Tomas J.
Published: February 2008

Die Fällung ist ein vielversprechender Prozess zur Nanopartikelherstellung, da er schnell, kostengünstig und verfahrenstechnisch einfach zu gestalten ist. Im Rahmen der vorliegenden Untersuchungen wurden Bariumsulfatpartikel in diskontinuierlichen Fällungsversuchen in einem Rührkesselreaktor hergestellt. Es wurden Partikelgrößen unter 100 nm erreicht. Die Partikelgrößenverteilungen hängen stark von der Vermischung und dem stöchiometrischen Verhältnis der Reaktanden sowie von der Stabilisierung der Partikeloberfläche ab.
Phosphorsäuredotierte Protonenleiter auf Basis von aminierten Membranen aus ETFE‐graft‐poly‐(glycidylmethacrylat)‐Derivaten
Authors: Schmidt C. , Schmidt‐Naake G.
Published: February 2008

Polymere Protonenleiter der so genannten zweiten Generation sollen eine Betriebstemperatur von deutlich über 100 °C bei keiner oder nur geringer Befeuchtung der Betriebsgase ermöglichen und so die Effizienz von Polymerelektrolyt‐Brennstoffzellen (PEM‐FC) erheblich steigern. Komposite aus basischen Polymeren und Säuren gelten seit einiger Zeit als aussichtsreiche Ansätze für Brennstoffzellensysteme, die bei verringerter Feuchte und erhöhten Temperaturen operieren. Basierend auf diesem Konzept werden in dieser Arbeit basische Polymermembranen vorgestellt, die durch strahlungsinduzierte Pfropfpolymerisation von Glycidylmethacrylat mit Butylacrylat und Acrylnitril auf Filmen aus Poly(tetrafluorethylen‐alt‐ethylen) (ETFE) und anschließender Umsetzung mit Alkylaminen erzeugt werden. Durch anschließende Dotierung mit Phosphorsäure – bis zu 86 Gew.‐% – können diese Matrices in Protonenleiter überführt werden, die auch bei 125 °C und ohne Befeuchtung hohe Leitfähigkeiten bis zu 60 mS/cm aufweisen. Die Säuredotierung der erhaltenen basischen Polymermatrices sowie die Charakterisierung des Polymer/Säure‐Komposits hinsichtlich thermischer und mechanischer Stabilität sind ebenfalls Teil dieser Arbeit.
High‐dose chemotherapy for recurrent medulloblastoma
Authors: Gajjar Amar
Published: February 2008

A stringently selected group of pediatric patients with recurrent medulloblastoma have been salvaged by high‐dose chemotherapy. Based on the pediatric experience, the authors of the current study used a retrospective institutional series to demonstrate that adult patients with recurrent medulloblastoma who are treated with high‐dose chemotherapy and autologous stem cell rescue enjoy a longer duration of disease control and overall survival than patients treated with standard‐dose chemotherapy at the time of disease recurrence.
Reactions of Pyridyl Side Chain Functionalized Indenes with Ru3(CO)12
Authors: Chen Dafa , Xu Shansheng , Song Haibin , Wang Baiquan
Published: February 2008

Reactions of the pyridyl side chain functionalized indenes 3‐R‐C9H7 [R = (C5H4N)CH2CMe2 (1), (MeC5H3N)CH2CMe2 (2), (C5H4N)CH2 (6)] with Ru3(CO)12 in refluxing xylene gave the facial coordinated indenyl cluster [μ3‐η5:η2:η2‐(C5H3N)CH2Me2C(C9H6)]Ru4(μ3‐CO)(CO)7 (8), the syn‐η5:η6‐coordinated indenyl cluster [μ‐η5:η6‐(MeC5H3N)CH2CMe2(C9H6)Ru2(CO)3]2 (10), and the η1:η2‐coordinated indenyl complex[η2‐(C5H3N)CH2(C9H7)][η1:η2‐(C5H4N)CH2(C9H6)]Ru2(CO)4(18), respectively, in addition to the normal diruthenium complexes [(η5‐RC9H6)Ru(CO)]2(μ‐CO)2 [R = (C5H4N)CH2CMe2 (7), (MeC5H3N)CH2CMe2 (9), (C5H4N)CH2 (17)]. When the pyridyl side chains were replaced by other bulky groups [R = tBu (3), PhCH2Me2C (4), (C9H6N)CH2Me2C (5)], the similar syn‐η5:η6‐coordinated indenyl clusters 12, 14, and 16 were also obtained. When 1 or 2 were treated with Ru3(CO)12 in refluxing heptane, the ionic clusters {[(C5H4N)CH2Me2C(C9H6)]Ru(CO)2}+[HRu6(CO)18]– (19), [(C5H4N)CH2Me2C(C9H8)]+[HRu6(CO)18]– (20), and complex 8 or ionic clusters {[(MeC5H3N)CH2Me2C(C9H6)]Ru(CO)2}+[HRu6(CO)18]– (21) and [(MeC5H3N)CH2Me2C(C9H8)]+[HRu6(CO)18]– (22) were obtained. Similar treatment of 5 or 6 with Ru3(CO)12 in refluxing heptane gave the ionic clusters [(C9H6N)CH2Me2C(C9H8)]+[HRu6(CO)18]– (23) or {[η3‐(C5H4N)CH(C9H7)][η2‐(C5H4N)CH2(C9H7)]Ru(CO)}+[HRu6(CO)18]– (24), respectively, in addition to complex 18 in the latter case. The molecular structures of 8, 9, 10, 14, 17, 18, 21, 22, and 24 were determined by X‐ray diffraction analysis.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Nonresectable carotid body tumor: Hybrid surgical procedure to achieve complete and safe resection
Authors: Hurtado‐Lopez Luis Mauricio , Fink‐Josephi Gustavo , Ramos‐Méndez Luis , Dena‐Espinoza Ernesto
Published: February 2008

Background

Carotid body tumors of Shamblin class III without free internal carotid, between the tumor and skull base, are considered nonresectable. The objective of this work is to describe a surgical technique that combines traditional and endovascular strategies to achieve a safe surgical resection of the carotid body tumor of this class.

Methods and Results

A female patient with a nonresectable carotid body tumor underwent placement of an endoprosthesis going from the common carotid artery to the internal carotid beyond the skull base (to secure cerebral circulation) excluding the external carotid artery. Forty‐five days later, the tumor was resected without vascular or cranial nerves injury, and bleeding amounted to 50 cm3. At 6 months, the patient is tumor free and asymptomatic.

Conclusion

This is the first known reported case that has been successfully resolved by combining endovascular and traditional strategies. The endoprosthesis maintained cerebral circulation, which otherwisewould have been impossible; besides, the vascular supply from the external carotid artery was excluded leading to a decrease in tumor size and a recovery of the subadventitial dissection plane, allowing for a successful and safe tumor resection. © 2008 Wiley Periodicals, Inc. Head Neck, 2008
Kinetic simulation model of protein secretion and accumulation in the cell microcapsules
Authors: Wikström J. , Syväjärvi H. , Urtti A. , Yliperttula M.
Published: February 2008

Background

In cell therapy, microencapsulated cells secrete therapeutic protein, which is further released from the microcapsules. In principle, some secreted, but unreleased, protein may accumulate in the microcapsules. The kinetic simulation model was built to simulate the potential accumulation of the protein in the microcapsules.

Methods

The alginate microcapsules were cross‐linked with divalent cations to encapsulate either flourescein isothiocyanate (FITC)‐dextrans (molecular weights = 4.3, 10.5, 43 kDa) or retinal pigment epithelial cells (ARPE‐19). The cells were genetically engineered to produce secreted alkaline phosphatase (SEAP). SEAP production from the cells was quantified with and without microcapsulation and, finally, the cells were killed with toxin to quantify the secreted but yet unreleased SEAP from the microcapsules. The empirical three‐compartment kinetic model was constructed based on the release of FITC‐dextrans of different molecular weights from the alginate microcapsules with different pore sizes. Protein secretion from the cells into the microcapsules was added to the model. The impact of the microcapsule wall permeability on the steady‐state amounts of secreted protein in the microcapsules and in the hypothetical target compartment in the body was simulated. The simulations were compared to the experimental data from the microencapsulated SEAP secreting ARPE‐19 cells.

Results

The model and the data show that substantial amounts (10–15 daily doses) of protein may accumulate in the microcapsules with poor wall permeability. At high permeability, the accumulation was insignificant. The pharmacokinetic simulations show that even a 1.5‐fold increase in the wall permeability may result in a substantial peak in the drug amount in the target compartment, especially if the elimination rate of the protein is high.

Conclusions

The kinetic simulation model for protein secretion from microcapsulated cells is a useful tool for the early kinetic prediction and risk assessment of cell therapy. Copyright © 2008 John Wiley & Sons, Ltd.
Transient resonance Raman spectroscopy and DFT calculations of metal‐to‐ligand charge transfer states of Cu(I) complexes of substituted 1,10‐phenanthroline ligands and their perdeuterated isotopomers
Authors: Howell Sarah L. , Gordon Keith C.
Published: February 2008

Cu(I) complexes of the type [Cu(L)(PPh3)2]+, where L is the bidentate ligand 4,7‐diphenyl‐1, 10‐phenanthroline (dip) and 3,4,7,8‐tetramethyl‐1,10‐phenanthroline (tem) and their perdeuterated analogues, have been synthesised and the transient resonance Raman spectra of these complexes have been measured. The spectra show two sets of bands, one due to the PPh3 ligands and the other due to L.− created through the metal‐to‐ligand charge transfer transition. Density functional theory calculations have been used to model ligands and complexes in the ground state and good agreement has been found between calculated and measured bands with a mean absolute deviation of 8–10 cm−1 for the ligands and 5 cm−1 for the complexes. Shifts in the bands due to deuteration have also been well predicted, with the shifts for most modes predicted to within 10 cm−1. The structure and spectra of the excited states have been modelled using two approaches. The reduced state [Cu(L.−)(PH3)2] was used for both complexes to predict the changes in the structure of the polypyridyl ligand and for [Cu(dip)(PPh3)2]+ the triplet state was also optimised. Both approaches show that similar structural changes in the ligand are predicted. In the case of [Cu(dip)(PPh3)2]+* and [Cu(dip.−)(PPh3)2], the calculated states are 3A2 and 2A2, respectively, consistent with experiment. Calculations on [Cu(tem)(PPh3)2]+* give a 3B1 state. This is not consistent with experimental results. For [Cu(tem.−)(PPh3)2] both the 2B1 and 2A2 states may be calculated and the experimental spectrum of [Cu(tem)(PPh3)2]+* is closer to that of the 2A2 [Cu(tem.−)(PPh3)2] species. Calculated wavenumbers are compared to measured transient resonance Raman L.− bands and found to have a mean absolute deviation of 8 cm−1 for the triplet state of [Cu(dip)(PPh3)2]+ and 16 cm−1 for the reduced state of [Cu(tem)(PPh3)2]+. Copyright © 2008 John Wiley & Sons, Ltd.
The effects of radiofrequency on skin: Experimental study
Authors: Alvarez Nuria , Ortiz Lidia , Vicente Vicente , Alcaraz Miguel , Sánchez‐Pedreño Paloma
Published: February 2008

Background and Objective

Radiofrequency represents the most recent skin‐rejuvenation treatment. The aim of this study was to study the changes in tissues and cells, as well as in the thickness and structure of the skin of guinea pigs following several sessions of radiofrequency.

Materials and Methods

Six sessions (1 session/week) of radiofrequency (Thermafine Lift device, Grupo Soliláser, S.L., Girona, Spain) were applied to the skin of guinea pigs. Biopsies were taken following each session and 2 months following the last application. The resultant samples were included in paraffin via the usual method, sectioned at 5 µm and stained with Haematoxylin‐Eosin, Alcian blue, Toluidine blue, van Gieson's and Verhoeff's stains. These techniques were used in order to observe possible changes in the thickness and structures of the skin: mucopolysaccharides and collagen and elastic fibres.

Results

The most relevant changes were found in the papillary dermis which underwent an expansion due to oedema and vascular congestion (first half of the experiment), followed by an increase in cellularity and the accumulation of intercellular substance. An increase in collagen, elastic fibres and mucopolysaccharides was observed.

Conclusion

The Thermafine Lift device caused no significant macroscopic or microscopic alterations in the skin of guinea pigs, yet increased both the thickness, as well as the mucopolysaccharide, collagen and elastic‐fibre content. Lesers Surg. Med. 40:76–82, 2008. © 2008 Wiley‐Liss, Inc.
Brain structural damage in spinocerebellar ataxia type 2. A voxel‐based morphometry study
Authors: Nave Riccardo Della , Ginestroni Andrea , Tessa Carlo , Cosottini Mirco , Giannelli Marco , Salvatore Elena , Sartucci Ferdinando , De Michele Giuseppe , Dotti Maria Teresa , Piacentini Silvia , Mascalchi Mario
Published: March 2008

Voxel‐based morphometry (VBM) enables an unbiased in‐vivo whole‐brain quantitative analysis of differences in gray matter (GM), white matter (WM) and cerebro‐spinal fluid (CSF) volumes. We assessed with VBM 20 spinocerebellar ataxia Type 2 (SCA2) patients with mild or moderate cerebellar deficit and 20 age and sex‐matched healthy controls. SCA2 patients showed a significant (P < 0.05 corrected for multiple comparison) symmetric loss of GM in the cerebellar vermis and hemispheres sparing lobules I,II, Crus II,VII, and X, and of the WM in the peridentate region, middle cerebellar peduncles, dorsal pons, and cerebral peduncles. The CSF volume was increased in the posterior cranial fossa. No GM, WM or CSF volume changes were observed in the supratentorial compartment. A mild (P < 0.05, >0.01) correlation was observed between the GM and WM loss and severity of the neurological deficit. In SCA2 patients with mild to moderate cerebellar deficit, GM and WM volume loss and CSF volume increase are confined to the posterior cranial fossa. © 2008 Movement Disorder Society
Late onset Wilson's disease: Therapeutic implications
Authors: Członkowska Anna , Rodo Maria , Gromadzka Grażyna
Published: March 2008

The clinical symptoms of Wilson's disease (WD) usually develop between 3 and 40 years of age and include signs of liver and/or neurologic and psychiatric disease. We report on an 84‐year‐old woman with WD. Despite the absence of treatment, the only symptom she presented with, until the age of 74 years, was Kayser‐Fleisher rings. At the age of 74, she developed slightly abnormal liver function. This case raises the following issues: (a) Should WD be considered in all patients of all ages who manifest signs related to the disease? (b) Are ATP7B mutations fully penetrant? (c) Should all patients diagnosed presymptomatically receive anticopper therapy? © 2008 Movement Disorder Society
Extending the range of diffusion times for regional measurement of the 3He ADC in human lungs
Authors: Wang Chengbo , Miller G. Wilson , Altes Talissa A. , de Lange Eduard E. , Cates Gordon D. , Mata Jaime F. , Brookeman James R. , Mugler John P.
Published: February 2008

A stimulated‐echo‐based technique was developed to measure the regional apparent diffusion coefficient (ADC) of hyperpolarized 3He during a single breathhold for diffusion times of 25 ms or greater. Compared to previous methods, a substantially shorter minimum diffusion time was achieved by decoupling diffusion sensitization from image acquisition. A hyperpolarized‐gas phantom was used to validate the method, which was then tested in four healthy subjects in whom regional ADC maps were acquired with diffusion times of 50, 200, and 1500 ms and a tag wavelength of 5 or 10 mm. ADC values from healthy subjects were in good agreement with reported literature values and decreased with increasing diffusion time. Mean ADC values were ≈0.07, 0.03, and 0.015 cm2/s for diffusion times of 50, 200, and 1500 ms, respectively. ADC maps were generally homogeneous, with similar mean values when measured with the same parameters in different subjects. Magn Reson Med 59:673–678, 2008. © 2008 Wiley‐Liss, Inc.
Quality of Care and Racial Health Disparities: A Strategic Overview
Authors: Chassin Mark R. , Anderson Rebecca M.
Published: February 2008

Substantial racial and ethnic disparities in health and health care exist in the United States. The Department of Health Policy at the Mount Sinai School of Medicine has developed a strategy for reducing those disparities that builds upon its quality improvement experience. This article discusses the utility of applying quality improvement principles to the development of interventions to eliminate underuse of effective treatments and reduce the disparities that may arise from this quality problem. We present a conceptual model of racial disparities in health and our underuse hypothesis. Parallels between our disparities research strategy and six sigma quality improvement methods are described. Finally, the article provides an example of how we have been able to successfully implement proven‐effective health improvement programs in the Harlem community even after grant funding has ended. Mt Sinai J Med 75:7–12, 2008. © 2008 Mount Sinai School of Medicine
Nonprofit versus corporate governance: An economic approach
Authors: Speckbacher Gerhard
Published: March 2008

This article proposes a new theoretical concept of nonprofit governance using transaction cost economics and the economic theory of contracts. After a short review of economic approaches to corporate governance, I clarify the specific nature of the governance problem in nonprofit organizations. Based on this analysis, I derive criteria for selecting an organization's relevant stakeholders. If stakeholders provide valuable specific resources without the protection of a comprehensive contract that details exactly how the organization is to use these resources, then such stakeholders seek decision and control rights in order to direct the use of the resources they have provided. I argue that the core problem of governance is how to enhance valuable specific contributions of the relevant stakeholders while keeping the costs of bargaining between stakeholders and the costs of collective decision making low. The theory developed is then applied in a discussion of practically relevant governance mechanisms, and the concept of governance is used to contribute to the discussion on the strengths and weaknesses of the nonprofit character of organizations from a governance perspective.
Creating stabilizers and safety nets for successor executives' high‐wire act
Authors: McKee Margaret C. , Driscoll Cathy
Published: March 2008

This article explores executive succession planning in a nonprofit health care organization with a strong values‐based culture. Case study research was used to explore how retiring executives have prepared the organization for their departure and have used various strategies in an attempt to limit any potentially negative impact.
Leadership development inside‐out in Africa
Authors: James Rick
Published: March 2008

Leadership development is a high priority for African nonprofit organizations, but we know very little about what causes leaders in Africa change their behavior and how. Most leadership development programs use imported Western models that at best pay only lip‐service to the very different culture and context in Africa. This article outlines the research findings of a three‐country study conducted in Malawi, Uganda, and Kenya. This study found that changes in leadership style, although individual and complex, followed an underlying pattern. External events catalyzed an inside‐out change process. Effective leadership development requires in‐depth understanding and application of local contextual and cultural issues. Ultimately, however, the process of leadership development is tied to deeper, universal principles of human behavior.
What would the princess want?
Authors: Chisolm Laura B.
Published: March 2008

Broken Trust: Greed, Mismanagement, and Political Manipulation of America's Largest Charitable Trust, by Samuel P. King and Randall W. Roth. Honolulu: University of Hawai'i Press, 2006. 336 pp., $26.00 cloth, $16.00 paper.
Playing hardball
Authors: Wyland Michael L.
Published: March 2008

Hardball Lobbying for Nonprofits: Real Advocacy for Nonprofits in the New Century, by Barry Hessenius. New York: Palgrave Macmillan, 2007. 222 pp., $65.00 cloth.

Lobbying for Social Change (3rd ed.), by Willard C. Richan. Binghamton, N.Y.: Haworth Press, 2006. 320 pp., $59.95 cloth, $32.95 paper.
Through a feminist lens
Authors: Perlmutter Felice Davidson
Published: March 2008

Grassroots NGOs by Women for Women: The Driving Force of Development in India, by Femida Handy, Meenaz Kassam, Suzanne Feeney, and Bhagyashree Ranade. Thousand Oaks, Calif.: Sage, 2006. 244 pp., $29.95 paper.
Memento of the post‐mortem
Authors: van Speybroeck D , van Krieken J , van Daal W , Ruiter D
Published: February 2008

When the Department of Pathology of the Radboud University Nijmegen Medical Centre in The Netherlands moved from its old to its new premises, the demolition of the marble post‐mortem tables was impending, taking with it the Department's (physical) memory. To keep the importance of this memory and of the post‐mortem itself on everyone's minds in the new building, the artist Piet Hein Eek was invited to incorporate these post‐mortem tables into a work of art. This became a triptych: the three post‐mortem tables were stood upright against the wall behind a mounted double sheet of glass, containing screen prints of enlarged microscopic images. The two emblems of pathology–post‐mortem tables and double glass slides containing specimens–were thus united into a fascinating work of art: a true memento of the post‐mortem, re‐embedded in the contemporary world by its design. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Neuronal nitric oxide synthase does not contribute to the modulation of pulmonary vascular tone in fetal lambs with congenital diaphragmatic hernia (nNOS in CDH lambs)
Authors: Roessingh Anthony S. de Buys , de Lagausie Pascal , Ibrahima Taline , Duong‐Quy Sy , Schneider Jean‐Christophe , Huang Xiao‐Lin , Mercier Jean‐Christophe , Aigrain Yves , Boulanger Chantal , Dinh‐Xuan Anh Tuan
Published: February 2008

Aim

The aim of this study was to determine the presence of the neuronal nitric oxide synthase (nNOS) in near full‐term lambs with congenital diaphragmatic hernia (CDH) and its role in the modulation of pulmonary vascular basal tone.

Methods

We surgically created diaphragmatic hernia on the 85th day of gestation. On the 135th, catheters were used to measure pulmonary pressure and blood flow. We tested the effects of 7‐nitroindazole (7‐NINA), a specific nNOS antagonist and of N‐nitro‐l‐arginine (l‐NNA), a nonspecific nitric oxide synthase antagonist. In vitro, we tested the effects of the same drugs on isolated pulmonary vessels. The presence of nNOS protein in the lungs was detected by Western blot analysis.

Results

Neither 7‐NINA nor l‐NNA modified pulmonary vascular basal tone in vivo. After l‐NNA injection, acetylcholine (ACh) did not decrease significantly pulmonary vascular resistance (PVR). In vitro, l‐NNA increased the cholinergic contractile‐response elicited by electric field stimulation (EFS) of vascular rings from lambs with diaphragmatic hernia.

Conclusion

We conclude that nNOS protein is present in the lungs and pulmonary artery of near full‐term lamb fetuses with diaphragmatic hernia, but that it does not contribute to the reduction of pulmonary vascular tone at birth. Pediatr Pulmonol. 2008; 43:313–321. © 2008 Wiley‐Liss, Inc.
Modules for cloning‐free chromatin tagging in Saccharomyces cerevisae
Authors: Rohner Sabine , Gasser Susan M. , Meister Peter
Published: February 2008

We describe a straightforward two‐step PCR‐based method to insert arrays of lac or tet operators (lacO or tetO) at specific loci in the budding yeast genome. The method entails insertion of a marker generated by PCR with classical long primers recognizing the locus of interest, followed by the replacement of this marker by a linearized plasmid bearing an array of lacI‐ or tetR‐binding motifs. Using this technique, loci located either in the yeast genome or on yeast artificial chromosomes can be efficiently tagged. We provide a set of plasmids with different markers for cloning‐free integration of lacO or tetO repeats into the yeast genome. Copyright © 2008 John Wiley & Sons, Ltd.
II. Implementation of the Criminal Court Statute in England and Wales
Authors: Warbrick Colin , McGoldrick Dominic , Cryer Robert
Published: February 2008

Although a few States ratified the Rome Statute for the International Criminal Court1soon after it was promulgated, the UK decided to prepare and pass implementing legislation prior to submitting its ratification. In England and Wales (and Northern Ireland),2the ICC Statute is implemented by the International Criminal Court Act 2001,3which came fully into force on 1 September 2001.4The UK ratified the ICC Statute on 4 October 2001, fulfilling its aim of being amongst the first sixty States to do so.5The Act has two major purposes, to ensure that the UK is able to co-operate fully with the International Criminal Court (ICC), and to enact into domestic law the substantive offences the ICC may assert jurisdiction over when it comes into being.6It is the purpose of this note to introduce the Act and point to some interesting issues that may arise in the future.