bluuebunny/crossref_metadata_2025 huggingface dataset:
Based on the 4D Label-free protein qualitative analysis method and coomassie brilliant blue method quantitative determination of protein content to improve the quality standards of Xiangdan injection
Authors: Xu Min , Ye Zhangkai , Chen Yuchen , Cai Jia , Zhu Shunpeng , Yang Qiang , Wen GuoLiang , Huang Ruizhen , Zhang Liang , Ye Qiang
Published: June 2024

Xiangdan injection (XDI), as a common Chinese medicine injection (CMIs), is mainly used clinically to activate blood circulation, relieve blood congestion and dilate coronary arteries. However, allergic reactions occasionally occurred during the use of XDI, which could be related to the protein in XDI. Therefore, we conducted research on the commercial XDI and tested it according to the requirements of the Chinese Pharmacopoeia for CMIs. Firstly, 4D-Label-free quantitative proteomics technique was used to identify the samples of XDI and Salvia miltiorrhiza (SM), eleven identical proteins were found. The results indicated that XDI contained trace proteins which come from SM with a molecular weight range of 15-181KD. Then the qualitative experiments about proteins were carried out via the sulfosalicylic acid (SA) method and the tannic acid (TA) method, which were required in the Chinese pharmacopoeia. To our surprise, the qualitative experiments in the Chinese pharmacopoeia could not precise identify the proteins in XDI. Unexpectedly, the reason is that the excipient Tween 80 in XDI would cause a false-positive reaction. Therefore the proteins in XDI were inspected qualitatively and quantitatively after eliminating false-positive reactions. The protein content in XDI was determined by coomassie brilliant blue method. It was discovered that the protein concentration was 3.038 mg/ml, which would not generate a positive reaction. Finally the combination of qualitative and quantitative protein experiments provide an exclusive identification method for XDI, which could promote the quanlity standards of XDI and guarantee the clinic safety.
Combustion and mechanical property enhancement strategy based on SA surface activated boron powders
Authors: Lu Jiaxin , Chen Chong , Zhang Bobo , Niu Kang , Xiao Fei , Liang Taixin
Published: June 2024

Boric acid and other impurities on the surface of boron (B) particles can interact with hydroxyl-terminated polybutadiene (HTPB), which can weak the mechanical properties and energy release efficiency of boron-based solid rocket propellants. In this paper, solvent evaporation induced self-assembly was used to coat the surface of B particles with stearic acid (SA) and the SA@B composite particles were prepared. The effects of SA coating on the combustion performance of B particles and the mechanical properties of HTPB matrix composites were investigated. The results showed that the SA coating enhanced the oxidation efficiency of B particles in air. The heat of combustion value of the SA@B composite particles, reached up to 30.29 MJ/g. During the combustion of SA@B composite particles, there are fewer molten solid particles surrounding the flame, which enhances the stability of B particles combustion process. Furthermore, the SA coating effectively enhanced the dispersion of B particles in HTPB. At a stretching speed of 100 mm/min, the tensile strength of the SA@B/HTPB composite materials is higher than that of the B/HTPB composite materials. Moreover, when the mass loading of the SA@B composite particles reaches 50 wt%, the tensile strength of SA@B/HTPB composite materials achieves 0.63 MPa. The compatibility between B particles and HTPB can be effectively improved by surface-activated B particles with SA, which is of great significance for the storage stability of boron-based solid rocket propellants.
Investigation of vibration dynamics and failure prediction of ball bearing in two rotor system: Qualitative and Quantitative approach
Authors: Duraisamy prakash , kumarasamy Suresh , Rajagopal Karthikeyan , Karthikeyan Anitha
Published: June 2024

The study investigates the vibration dynamics and failure prediction of ball bearings under common failure scenarios. The experiments involve normal bearings, faulty bearings, and conditions involving external rubbing. Various analyses such as time series analysis, Fast Fourier Transform, recurrence analysis, and the Dragon-King test are employed for the classification of different vibrations created in the system. These analyses aim to assess the condition of faulty bearings and detect any anomalies or extreme events. The complementary cumulative distribution function (CCDF) proves to be an effective method for identifying outliers in temporal data, providing the probability of events in the time series. The CCDF plot is specifically utilized to reveal the probability of a dragon-king extreme event in the case of rubbing. Extracting essential recurrence metrics from Recurrence Plots, such as recurrence rate, mean recurrence time, recurrence time entropy, laminarity, and determinism, allows for a quantitative understanding of the system's behavior. The study contributes valuable insights into the vibrational characteristics of ball bearings and offers a robust methodology for predicting failures and identifying abnormal events in complex mechanical systems.
Fourier PD and PDUNet: Complex-valued networks to speed-up MR Thermometry during Hyperthermia
Authors: Khatun Rupali , Chatterjee Soumick , Bert Christoph , Wadepohl Martin , Ott Oliver J. , Semrau Sabine , Fietkau Rainer , Nürnberger Andreas , Gaipl Udo S. , Frey Benjamin
Published: June 2024

Hyperthermia (HT) in combination with radio-and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures of 39 to 43 °C for 60 minutes. Temperature monitoring can be performed noninvasively using dynamic magnetic resonance imaging (MRI). However, the slow nature of MRI leads to motion artefacts in the images due to the movements of patients during image acquisition time. By discarding parts of the data, the speed of the acquisition can be increased-known as Undersampling. However, due to the invalidation of the Nyquist criterion, the acquired images have lower resolution and can also produce artefacts. The aim of this work was, therefore, to reconstruct highly undersampled MR thermometry acquisitions with better resolution and with less artefacts compared to conventional techniques like compressed sensing. The use of deep learning in the medical field has emerged in recent times, and various studies have shown that deep learning has the potential to solve inverse problems such as MR image reconstruction. However, most of the published work only focusses on the magnitude images, while the phase images are ignored, which are fundamental requirements for MR thermometry. This work, for the first time ever, presents deep learning based solutions for reconstructing undersampled MR thermometry data. Two different deep learning models have been employed here, the Fourier Primal-Dual network and Fourier Primal-Dual UNet, to reconstruct highly undersampled complex images of MR thermometry. MR images of 44 patients with different sarcoma cancers who have received the HT treatment in a combination of radiotherapy/chemotherapy were used in this study. It was observed that the method was able to reduce the temperature difference between the undersampled MRIs and the fully sampled MRIs from 1.5 °C to 0.5°C.
The effect of 6 weeks of high intensity interval training (HIIT) on expression of mirRNA29-c and mirRNA146-a in the hippocampus of streptozotocin- induced diabetic male rats
Authors: Ichi Mehdi Soltani , Shabkhiz Fatemeh , Kordi Mohammadreza
Published: June 2024

Background/objectives:
MicroRNAs have been reported as potentially useful biomarkers for various diseases, including diabetes, heart diseases, and neurological diseases. The aim of this study was to assess whether microRNA-146a and its inflammatory mediator (TNF-a) and microRNA-29c may be changed in the hippocampus of streptozotocin-induced diabetic rats, after a period of high – intensity interval training.
Methods
Twenty-four male Wistar rats (180 ± 10 g, 8–10 weeks age) were assigned to 4 groups: control (C), diabetes (D-1w), diabetes (D-6w), and diabetes high-intensity interval training (DHIIT). Diabetes induced by the single-dose injection of streptozotocin (STZ; 55 mg/kg dissolved in 0.1 M of citrate buffer; pH 4.5; i.p.) in 12-h fasted and blood sugar higher than 250 was considered diabetic. The effects of six weeks of HIIT on hippocampus microRNA-146a, microRNA-29c, as well as evaluation of tumor necrosis factor-alpha (TNF-α ) in serum were evaluated using Real-Time PCR and ELISA techniques respectively.
Results
The results indicated a reduction in expression of miR-146a and an increase in expression of microRNA-29c genes in the hippocampus of diabetic rats compared to control. Also TNFα increased in the D groups in comparison with C group. However, HIIT training in DHIIT significantly decreased the microRNA-29c and TNFα and increased microRNA-146a expression in comparison of D-6w group.
Conclusion
Our results implied that increased hyperglycemia and inflammation status were associated with brain impairment in DM rats, which were negatively correlated with miR-146a and microRNA-29c expression. It seems that HIIT training improves hypoglycemic and inflammatory conditions in diabetic rats.
What are the perceptions and lived experiences of Canadian injured workers about the provision of physiotherapy services using telerehabilitation?
Authors: Hudon Anne , Miciak Maxi , Slade Teri , Lovo Stacey , Whittaker Jackie L. , Côté Daniel , Feldman Debbie E. , Kairy Dahlia , Laberge Marie , McKeen Beverley , Cooper Lynn , Gross Douglas
Published: June 2024

Purpose
Despite evidence of efficacy, the effectiveness of telerehabilitation in real-world clinical settings is still largely unknown. Telerehabilitation requires a substantial transformation of the organization and delivery of traditional services. Considering that a virtual setting can create unique challenges for providing physiotherapy services and given the physical and potential hands-on nature of evidence-based assessments and interventions, it is important to investigate what injured workers think of receiving physiotherapy care via telerehabilitation and to examine if rehabilitation needs are adequately met.
Methods
A qualitative interpretive description study was conducted to explore the perspectives and experiences of 17 injured workers receiving physiotherapy via telerehabilitation. Data were collected through semi-structured interviews with participants from three provinces in Western Canada and analysed using thematic analysis.
Results
Implementation of telerehabilitation during the COVID-19 pandemic resulted in mixed perceptions from injured workers. Some viewed telerehabilitation as a resourceful option for providing services during the pandemic lockdown, resulting in maintained communications while overcoming barriers to services (e.g., rural/remote workers, transportation barriers, etc.). However, many thought telerehabilitation was inferior to in-person therapy for assessment and when ‘hands-on’ interaction was needed. Many believed a hybrid option may be ideal now that pandemic restrictions are lifted, with telerehabilitation supplementing in-person physiotherapy when needed.
Conclusions
Telerehabilitation was viewed as a resourceful option during the pandemic and in certain clinical situations (e.g., rural/remote). Workers should be able to make informed choices about service delivery format.
A Study on the Consumer Satisfaction Towards Mobile Banking Services of State Bank of India- With Special Reference to Dharamshala
Authors: Dhiman Indu Dhiman Indu , Sharma Puneeta Sharma Dr. Puneeta
Published: June 2024

The banking industry and its customers have benefited greatly from recent telecommunications innovations. One such innovation is mobile banking, which allows customers to communicate with banks via cell phones and receive services like account information, fund transfers, short message services, check book issuance, and more. Mobile banking is a significant and developing method of carrying out financial operations. Currently, practically every bank in the globe offers "Mobile Banking" services to its customers. This research aims to investigate the Preference level of customers for Mobile Banking Services and the satisfaction level of customers towards Mobile Banking Services of SBI. This study is conducted in Dharamshala and customers using Mobile-banking service in State Bank of India (SBI).The present study has been collected from primary data on the basis of issue questionnaire, the sample size for study was only 81 mobile banking users of SBI.
Inflation Reduction Act incentives increase cost-competitiveness of lower-footprint clean hydrogen-based sustainable aviation fuel
Authors: Phadke Amol , Bennett Jose Luis Dominguez , Popovich Natalie , Paliwal Umed
Published: June 2024

This study demonstrates that the US 2022 Inflation Reduction Act (IRA) provides a pathway to lower the cost of producing sustainable aviation fuel (SAF) by up to a third, making it cost-competitive with conventional jet fuel. We investigate three hydrogen-intensive electrofuel pathways—i.e., using carbon from biomass, point source emissions, and direct air capture (DAC)—for all contiguous US counties. In particular, the SAF production pathway using hydrogen produced from off-grid renewables and carbon from biomass offers several promising benefits, namely a 2.5-fold increase in biomass efficiency; 60% and 58% decreases in water and land use, respectively; and 93% and above-99% carbon emissions reductions compared to biomass-based SAF strategies and fossil jet fuel, respectively. This approach requires an average of only 4% of counties’ renewable electricity potential to meet 2050 SAF production targets. Consequently, we suggest stakeholders develop a revised strategy to significantly scale US deployment of economically viable SAF that leverages low-cost clean hydrogen supply enabled by the high-quality renewable potential and long-lasting IRA incentives.
Two-beam Interference Microscopy: high-resolution multi-scale light-sheet imaging from subcellular structures to whole organs
Authors: Fei Peng , Zhou Yao , Guo Xinyi , Mao Shiqi , Liu Jianchao , Zhang Meng , Li Mengmeng , Zhu Jingtan , Yi Yating , Ye Chaoliang , Ma Yifan , Yang Qihang , Wang Zhaofei , Si Wentian , Fang Yuekun , Li Dongyu , Chen Liting , Jiang Man , Zhao Hu , Yu Tingting , Zhu Dan , Kuang Dong , Wang Guoping , Zhang Yu-Hui
Published: June 2024

Despite offering rapid and gentle 3D imaging of biological samples, the revolution by light-sheet fluorescence microscopy faces challenges due to optical constraints and limited geometry flexibility, hindering its widespread application. Here we present Two-beam Interference Microscopy (TIM), which sweeps the interference pattern of two symmetric laser sheets to achieve horizontal plane illumination and orthogonal wide-field detection for the first time using a single objective. The geometry-unconstrained TIM yields adaptive optical sectioning of samples with various sizes and mounting approaches. It enables high-speed (over 150 megavoxels/s), adaptive-resolution (~200 nm to ~2500 nm), nanoscale-to-mesoscale 3D imaging ranging from single organelles within a live cell (×100), to a whole mouse brain containing tens of millions of neurons (×4 tile stitching). TIM exhibits remarkably high versatility while achieving superior spatiotemporal resolution. With feedback-controlled imaging strategies, intelligent TIM demonstrates in situ trans-scale visualization from entire brain slices to single dendritic spines, and efficient event-triggered imaging of CAR-T/tumor cells’ cytotoxic interactions.
Proposed Student Learning Model in a Hybrid Learning Environment
Authors: Osajiuba Ojoma , Pardede Eric , Tomy Sarath
Published: June 2024

Hybrid learning has become a new norm in higher education institutions, particularly since the COVID-19 pandemic. The hybrid learning environment is faced with many challenges and issues. The motivation for this study is to further substantiate this potential new normal by exploring strategies to address the challenges faced by students in the new learning environment. A learning model was proposed as a strategy for tailoring learning activities according to individual preferences to achieve optimal productivity. Although there are many existing learning strategies and styles, there is a need to propose a model that accommodates student engagement online and, in the classroom, simultaneously. The proposed learning model is formulated to harness the advantages and address the challenges faced by students in hybrid learning environments. The proposed model is called the AIMS (agile, intermittent, meteoric and self-pace) learning model and consists of six characteristic features (study habit/skills, study medium, class participation, learning environment, teaching method format, and assessment preference). The characteristic features were identified from the literature and from several existing learning style models to form the basis for the AIMS learning model. Proposing this learning model is necessary to address the challenges students face in hybrid learning environments, and addressing these challenges can lead to the development of tailored learning and teaching strategies that cater to diverse learning styles, thereby improving the overall learning experience of students. These improved practices positively affect academic performance and can help in the development of tools and platforms that better cater to the diverse learning styles of students. Universities can help distribute resources more effectively, and academics/educators can benefit from these research findings by gaining insights into effective pedagogical approaches to ensuring an optimized learning environment.
Factors Influencing Suicidal Thoughts in Rural Tamil Nadu Adolescents
Authors: R Anjit Raja , B Nagarajan
Published: June 2024

Suicide is a pressing public health issue among adolescents globally, particularly in low- and middle-income regions like Tamil Nadu. Despite ample evidence from developed nations linking suicidal ideation (SI) in adolescents to social and individual factors, research from low- and middle-income countries is limited. This study is the first to explore SI prevalence and its social determinants among rural Tamil Nadu adolescents, focusing on socioeconomic status (SES). Drawing from two studies conducted in 2023, involving 4,598 adolescents aged 13-19, this paper utilized data from a cross-sectional survey in a rural Tamil Nadu community. Results from Study - I revealed a lifetime SI prevalence of 14%, with a significant proportion being female (68%), unmarried (5.8%), and students (6.4%). SI was notably associated with age, education, occupation, and living arrangements. Adolescents aged 17-19, with SSC/HSC education, day laborers, and those not living with parents showed elevated odds ratios for SI. SI prevalence was higher among adolescents from low-income families, with parental education, marital status, and house ownership significantly influencing SI odds. Adolescents with single parents and those with parents having lower education levels exhibited higher SI odds. However, adolescents from households owning a house had lower SI odds.This research underscores a moderately high prevalence of SI among rural Tamil Nadu adolescents. It highlights the significant influence of personal and familial characteristics, even after adjusting for potential confounders.
Understanding these factors is crucial for developing effective interventions to address adolescent suicidal ideation in low-resource settings.
Natural aliphatic lipids and sterols in sediments from Obhur Lagoon, Red Sea coast of Saudi Arabia: Concentrations, spatial distributions, and sources
Authors: Rushdi Ahmed I. , Alharbi Hattan A. , Rasul Najeeb , Bazeyad Abdulqader , Simoneit Bernd R. T. , Goni Miguel A. , Al-Mutlaq Khalid F.
Published: June 2024

Samples from the upper surface sediments of Obhur Lagoon - north Jeddah were collected to determine the concentrations, spatial distribution, and sources of natural lipids. The lagoon was divided into three zones based on their immediate ecosystems: Z I (adjoining inland), Z II (the region between Z I and the adjacent coastal Z III), and Z III (coastal region). The major natural biogenic lipid compounds of the total extractable organic matter (TEOM) were n-alkanes (partial), fatty acids, fatty alcohols, and steroids.
The n-alkanes of biogenic sources were mainly from terrestrial higher plant wax and decreased from about 38% to 12% from Z I to Z III. Their aquatic algal and diatom sources increased from ~ 1% to 8% for Z I to Z III and microbial inputs decreased from ~ 3% to 0.5% for Z I to Z III. Relative concentrations of fatty acid inputs from higher plants varied from ~ 6% in Z I, 4% in Z II, and 5% in Z III; from aquatic algae sources ~ 80% in all regions; and from microbes ~14-12% with a slight decrease from Z I to Z III. The terrestrial input of fatty n-alcohols decreased from ~ 32% to 11% for Z I to Z III, from ~ 62% to 45% in Z I to Z III from aquatic algae and diatom sources, whereas microbial inputs varied around 10%. Steroid inputs from terrestrial plants were in decreasing order from Z I (37%) to Z III (16%), whilst from the aquatic biota, they increased from Z I (58%) to Z III (76%). The microbial inputs of steroids were in the order of Z III (11.5%) > Z II (9.9%) > Z I (9.4%).
The contributions of the total natural lipids from terrestrial sources decreased from Z I (42.8%) to Z III (19.2%), whereas the aquatic source component increased from Z I (53.0%) to Z III (77.4%). The results indicate that the lagoon biogeochemistry is influenced by the immediate ecosystems, hydrodynamic of the lagoon, and human and social activities in the area.
Lizard-Moth Flame Optimization Algorithm for Large-Scale Global Optimization Problems
Authors: Singh Prabhat Ranjan , Sing Vaibhav Kumar , Chaurasia Sachchida Nand , Singh Vivek Kumar
Published: June 2024

This paper introduces a disruptive strategy, namely a lizard-hunting approach, into the classical Moth Flame Optimization (MFO) algorithm. The conventional MFO emulates a moth's navigation pattern around artificial light at night but tends to face stagnation due to the flame's exploitative tendencies, often getting trapped in local optima, particularly in higher-dimensional problems. The research motivation stems from the need to disrupt small groups stuck at various local optima after a certain number of iterations. To address the limitations of the existing MFO, the proposed Lizard-Moth-Flame Optimization (L-MFO) algorithm is put forth. In L-MFO, moth positions are classified into outlier and non-outlier categories using a clustering method in each iteration. Following this categorization, non-outliers are divided into highly and less densely populated subgroups, with the densely crowded group considered closer to the solution. However, a distinctive aspect of the lizard's behaviour in L-MFO is its inclination towards the less crowded group, reflecting a slower update. When a moth detects a lizard within its range and at the same angle, moths within the group either flee in the opposite direction or move towards a densely crowded group. This strategic response mitigates the issue of stagnation, enhancing the algorithm's overall performance. The proposed L-MFO algorithm undergoes a comprehensive evaluation by being compared with other state-of-the-art meta-heuristic algorithms. The assessment involves testing on twenty-three CEC-2005 benchmarks across different dimensions (10, 30, 50, 100, 500, 1000, 2000, and 5000), eight engineering problems, and 36 CEC-2017 benchmark functions with 10, 50 and 100 dimensions. The robustness of the algorithm is examined through convergence and divergence analysis, Wilcoxon signed-rank test, Two-tailed Mann-Whitney U test, and boxplot analysis. The experimental and statistical results consistently demonstrate the superior performance of L-MFO over other algorithms.
WITHDRAWN: Evaluation of Spatial Performance in X-ray Imaging Detectors: CTF, MTF, LSF, and ESF Analysis
Authors: SOLOMON GIRMA BINIYAM , Diyor KHAZRATOV , Kuvondik KODIROV , Brombal LUCA
Published: June 2024

This study was conducted at the University of Trieste's Department of Physics, focusing on the comprehensive characterization of the spatial response of an X-ray imaging detector. The primary objective was to measure and analyze the Contrast Transfer Function (CTF), Modulation Transfer Function (MTF), Line Spread Function (LSF), and Edge Spread Function (ESF) to evaluate the detector's performance. Using a well-calibrated X-ray source, various test patterns and phantoms were imaged to acquire data. The CTF was assessed by analyzing the contrast response of the detector to a series of bar patterns with varying spatial frequencies. The MTF was derived from the Fourier transform of the LSF, which was obtained by scanning a narrow slit across the detector. The LSF provided detailed insights into the detector's response to a sharp line source. The ESF was measured by imaging a sharp edge, and subsequent differentiation yielded the LSF. These measurements were conducted under controlled conditions to ensure accuracy and repeatability. The results highlighted the spatial resolution capabilities and limitations of the X-ray imaging detector, providing a detailed understanding of its performance metrics. This comprehensive characterization is crucial for optimizing detector design and improving image quality in various applications, ranging from medical imaging to industrial inspection.
The role of soluble epoxide hydrolase in macrophage and astrocyte polarization
Authors:   , Li Xiaoming
Published: June 2024

Polyunsaturated fatty acids (PUFAs) play essential roles in mediating inflammation and its resolution. PUFA metabolites generated by the cytochrome P450 (CYP) - soluble epoxide hydrolase (sEH) axis are known to regulate macrophage activation/polarization but little is known about their role in the resolution of inflammation. Monocytes were isolated from murine bone marrow or human peripheral blood and differentiated to naïve macrophages (M0). Thereafter cells were polarized using LPS and IFNγ (M1), IL-4 (M2a), or TGFβ1 (M2c). Gene expression was analyzed by RNA sequencing, RT-qPCR and Western blotting. Phagocytosis of zymosan and oxo-LDL were also assessed in vitro. Zymosan-induced peritonitis combined with immune cell profiling was used to evaluate the resolution of inflammation in vivo. The expression of sEH was comparable in M0, M1 and M2a macrophages but markedly elevated in M2c polarized cells. The increase in sEH expression elicited by TGFβ relied on the TGFβ receptor ALK5 and the phosphorylation of SMAD2, which was able to bind to the sEH promoter. In macrophages lacking sEH, M2c polarization was incomplete and characterized by lower levels of pro-resolving phagocytosis associated receptors (Tlr2 and Mrc1), as well as higher levels of the pro-inflammatory markers; Nlrp3, IL-1β and TNFα. Fitting with the failure to upregulate phagocytosis associated receptors, the uptake of zymosan and ox-LDL was less efficient in M2c macrophages from sEH-/- mice. The latter animals also demonstrated a retarded resolution of inflammation (zymosan-induced peritonitis) in vivo with fewer resident macrophages and recruited macrophages. PUFA profile analysis indicated decreased sEH substrates e.g., 11, 12-EET, as well as increased sEH products e.g., 11, 12-DHET, indicating an increased sEH activity in M2c macrophages. Taken together, our data indicates that sEH expression is required for the effective M2c polarization of macrophages and thus the resolution of inflammation.
Dismantling the Ethnographer’s House
Authors: Loysa Carolin
Published: June 2024

Following Audre Lorde, this paper reflects on how to decolonize the ethnographic endeavor, arguing that every ethnographic inquiry should begin with a critical evaluation of our own class consciousness in relation to our field, and focusing on how class consciousness is inscribed onto our own bodies no less than onto the bodies of our interlocutors. Shopping malls are epitomes of neoliberal capitalism, serving as spaces where middle classes converge under one roof. Particularly in a neo-colonial context like Mexico’s, malls tease questions of class in a distinctive manner by utilizing the body as advertising platform. This paper argues that my position as white upper-middle-class (cis)woman from the global north was not only the primary tool that facilitated this research but a tool that significantly influenced its direction and focus. Simultaneously, it raised broader questions concerning intersectional inequalities under neoliberal capitalism and underscores our ethical responsibilities as ethnographers.
Propriedades físicas e mecânica de espécies do Ecótono Cerrado-Pantanal em função dos atributos do solo
Authors: Oliveira Jean Carlos Lopes de , Gouvêa Adriana de Fátima Gomes , Panachuki Elói , Câmara Ana Paula , Monteiro Felipe das Neves
Published: June 2024

Estabelecer uma relação entre os atributos do solo e a qualidade da madeira pode a princípio ser um grande desafio, contudo, quando o solo passa a ser considerado como fator de influência na qualidade do produto final, por afetar a taxa de crescimento dos sítios florestais, essa análise torna-se necessária. Todavia, o efeito sobre a qualidade da madeira em espécies nativas é pouco conhecido e explorado. O objetivo deste trabalho foi avaliar os atributos físicos dos solos e as propriedades física e mecânica da madeira de quatro espécies nativas do ecótono cerrado-pantanal e correlacioná-los. O material, proveniente do município de Aquidauana, inserido no ecótono cerrado-pantanal, foi constituído das espécies: Terminalia argentea, Callisthene fasciculata, Tabebuia roseo-alba e Cordia glabrata, das quais foram abatidas três árvores de cada espécie. O solo coletado em cada unidade amostral foi analisado quanto à densidade, macroporosidade, microporosidade, porosidade total, densidade relativa e textura. Já na madeira de cada espécie, analisou-se a relação cerne/alburno, a densidade básica nestas distintas regiões e a compressão paralela às fibras. A densidade básica das madeiras avaliadas apresenta diferença significativa entre as espécies dentro de cada região, não se diferenciando entre as regiões de cerne e alburno. As quatro espécies nativas respondem igualmente para o ensaio mecânico, tanto na região do cerne quanto do alburno. Não há correlação significativa entre os atributos do solo e as características da madeira.
Identification of hazards for human health under chemical pollution in air inside in-patient hospitals
Authors:   Centre for Strategic Planning and Management of Biomedical Health Risks, 10 Pogodinskaya St., build. 1, Moscow, 119121, Russian Federation, Malysheva A.G. , Kalinina N.V. ,   Centre for Strategic Planning and Management of Biomedical Health Risks, 10 Pogodinskaya St., build. 1, Moscow, 119121, Russian Federation
Published: June 2024

Use of various physical and chemical research techniques, including chromato-mass-spectrometry, made it possible to identify and quantify more than 40 organic compounds in air inside healthcare organizations, including saturated, unsaturated, cyclic, and aromatic hydrocarbons; terpenes, alcohols, aldehydes, esters, ketones, halogen-containing compounds, and organic acids. Levels of ethanol, dichloromethane, carbon tetrachloride, ethyl acetate, propyl acetate, acetone, terpene hydrocarbons, and acetic acid made the main contribution to the total content of all identified compounds. Most detected substances were present in concentrations not exceeding hygienic standards, except for chloroform and iodoform, the levels of which were up to 2 times higher than average daily MPL in intensive care wards and a bronchoscopy room. Organic acids and chlorinated organic compounds were found in elevated concentrations compared with insides of non-medical public buildings. Among the wide list of identified substances, hygienic standards have not been established for more than 70% of compounds and it is not possible to give a hygienic assessment of hazards or safety of their presence in air inside healthcare facilities. Despite that, the information obtained in this study is extremely useful for accomplishing an important stage in health risk analysis, which is identification of hazards for health of patients and healthcare workers posed by chemical air pollution inside healthcare organizations when using the risk analysis methodology. In this study, we assessed effects produced by operations of UV recirculator irradiators for air disinfection on its chemical composition inside healthcare institutions. The assessment showed that when such devices worked in the presence of patients and staff, there was an increase in the amount of pollutants in air and their total concentration grew from two to more than four times. When analyzing risks for health of staff and patients, hazard identification within risk-based control of chemical air pollution in the hospital environment should include monitoring of formaldehyde, styrene, ammonia, ethanol, isopropanol, chloroform, dichloroethane, acetic acid along with identification of a wide range of volatile organic compounds; it should also cover ammonia as one of the priority pollutants occurring in the environment from human excretory products.
Anthropometric indices and bioimpedance body composition as ontogenetic indicators to describe risk of obesity
Authors:   Scientific Center “Arktika”, Far Eastern Branch of the Russian Academy of Sciences (SC “Arktika” FEB RAS), 24 Karl Marx St., Magadan, 685000, Russian Federation, Alyoshina O.O. , Averyanova I.V. ,   Scientific Center “Arktika”, Far Eastern Branch of the Russian Academy of Sciences (SC “Arktika” FEB RAS), 24 Karl Marx St., Magadan, 685000, Russian Federation
Published: June 2024

The body mass index does not distinguish body fat mass from fat-free mass and does not capture changes in these parameters. The aim of this study was to establish an association between anthropometric indexes and bioimpedance indicators with age-specific obesity on the example of male population in the Magadan oblast. To achieve it, we examined 586 males who lived in the Magadan oblast by using conventional methods for assessment of physical development. The ROC analysis was performed and the area under the ROC curve (AUC) was measured. The analysis of the obtained research data established a significant decrease in FFMI values with age (from young males to elderly ones) together with growing FMI, FMI/FFMI ratio, total body fat and the waist-to-hip ratio. To determine an optimal BMI value as an indicator eligible to diagnose obesity, a ROC-curve was built to describe a relationship between BMI and FMI/FFMI value < 0.4 cu. It showed that when BMI ranged between 22 kg/m2 and 25.0 kg/m2 in young males, bioimpedance values corresponded to the physiological norm; in the early maturity group, the optimal BMI cut-off point for diagnosing obesity was 26.5 kg/m2; the optimal BMI range in the 2nd maturity group was 24.0–27.5 kg/m2. It is noteworthy that the ROC-analysis turned out to have no predictive significance among elderly men; this indicates that BMI is hardly eligible for being used as an indicator of obesity risk in this period of ontogenesis. Classical BMI ranges cannot be considered a clear indicator to diagnose obesity among males in the Magadan oblast whereas indicators obtained by bioimpedance analysis (FMI/FFMI ratios) can be used as relevant indicators when assessing risks of obesity and sarcopenia in the analyzed population.
WEE Family Kinase Inhibitors Combined with Sorafenib Can Selectively Inhibit HCC Cell Proliferation
Authors: Chen Anling , Yin Ke , Liu Yu , Hu Lei , Cui Qianwen , Wan Xiaofeng , Yang Wulin
Published: June 2024

Background:

Sorafenib is currently the first choice for the treatment of patients with advanced
hepatocellular carcinoma, but its therapeutic effect is still limited.

Objectives:

This study aims to examine whether WEE family kinase inhibitors can enhance the anticancer
effect of sorafenib.

Methods:

We analyzed the expression levels of PKMYT1 kinase and WEE1 kinase in HCC,
studied the inhibitory effect of PKMYT1 kinase inhibitor RP-6306, WEE1 kinase inhibitor
adavosertib combined with sorafenib on the proliferation of HCC cells, and detected the effect of
drug combination on CDK1 phosphorylation

Results:

We found that PKMYT1 and WEE1 were upregulated in HCC and were detrimental to
patient survival. Cell experiments showed that both RP-6306 and adavosertib (1-100 μM) inhibited
the proliferation of HCC cell lines in a dose-dependent manner alone, and the combination of
the two drugs had a synergistic effect. In HCC cell lines, sorafenib combined with RP-6306 or
adavosertib showed a synergistic antiproliferation effect and less toxicity to normal cells. Sorafenib
combined with RP-6306 and adavosertib further inhibited the proliferation of HCC cells
and caused complete dephosphorylation of CDK1.

Conclusion:

Taken together, our findings provide experimental evidence for the future use of sorafenib
in combination with RP-6306 or adavosertib for the treatment of HCC.
Supervised Learning based E-mail/ SMS Spam Classifier
Authors: Kumar Satendra , Kumar Raj , Saini Ashish
Published: June 2024

Background:

One of the challenging problems facing the modern Internet is spam,
which can annoy individual customers and wreak financial havoc on businesses. Spam communications target customers without their permission and clog their mailboxes. They consume
more time and organizational resources when checking for and deleting spam. Even though
most web users openly dislike spam, enough are willing to accept lucrative deals that spam remains a real problem. While most web users are well aware of their hatred of spam, the fact
that enough of them still click on commercial offers means spammers can still make money
from them. While most customers know what to do, they need clear instructions on avoiding
and deleting spam. No matter what you do to eliminate spam, you won't succeed. Filtering is
the most straightforward and practical technique in spam-blocking strategies.

Method:

We present procedures for identifying emails as spam or ham based on text classification. Different methods of e-mail organization preprocessing are interrelated, for example, applying stop word exclusion, stemming, including reduction and highlight selection strategies to
extract buzzwords from each quality, and finally, using unique classifiers to Quarantine messages as spam or ham.

Results:

The Nave Bayes classifier is a good choice. Some classifiers, such as Simple Logistic
and Adaboost, perform well. However, the Support Vector Machine Classifier (SVC) outperforms it. Therefore, the SVC makes decisions based on each case's comparisons and perspectives.

Conclusion:

Many spam separation studies have focused on recent classifier-related challenges. Machine Learning (ML) for spam detection is an important area of modern research. Today,
spam detection using ML is an important area of research. Examine the adequacy of the proposed work and recognize the application of multiple learning estimates to extract spam from
emails. Similarly, estimates have also been scrutinized.
Immobilization of Cutinase from Fussarium oxysporum into Sea Sand Matrix for Catalytic Degradation of Polyethylene Terephthalate (PET)
Authors:   Chemistry Department, Faculty of Mathematics and Natural Science, Brawijaya University, Prameswari Tira P. K. , Sutrisno Sutrisno ,   Chemistry Department, Faculty of Mathematics and Natural Science, Brawijaya University, Roosdiana Anna ,   Chemistry Department, Faculty of Mathematics and Natural Science, Brawijaya University
Published: June 2024

Cutinase is an enzyme that can be used as a catalyst in the hydrolysis reaction of polyethylene terephthalate (PET) waste into terephthalic acid and ethylene glycol. Generally, cutinase has low stability in its free form. Therefore, to increase cutinase stability, cutinase needs to be immobilized. In this study, cutinase was immobilized into a sea sand matrix by adsorption technique. The purpose of this study was to determine the optimum conditions of PET hydrolysis (pH, temperature, and incubation time), and to study the ability of immobilized cutinase for catalytic degradation of PET. The results show that immobilized cutinase has optimum conditions at pH 8, temperature of 50 °C, and incubation time of 24 hrs. Moreover, the immobilized cutinase can be used for up to three cycles with a residual activity percentage of 66.2% and an activity value of 23.224 nmol. g-1. min-1. The total enzyme activity of immobilized cutinase after being used in three cycles was 89.99 nmol. g-1. min-1 or 28.6% of its free enzyme activity.
De dode vrouw spreekt: neurodiverse taal in Elfriede Jelineks Ulrike Maria Stuart
Authors: Van der Gucht Liselotte , Verwee Jeanne
Published: June 2024

Die germanistische Literaturwissenschaft betrachtet Elfriede Jelineks Sprache oft als gefühls- oder subjektlos. Der Zynismus der Autorin soll in ihren Texten enthalten sein und regt zur Suche nach dessen psychologischen oder gar pathologischen Ursachen an. Im Gegensatz dazu werfen wir einen neuen Blick auf die Sprache im Drama Ulrike Maria Stuart. Die Figuren, zwei tote Königinnen, verwenden eine neurodiverse ‘Gegensprache’, die zu einer Neuinterpretation von Jelineks sogenannter Antipsychologie führt. Die tote Frau kämpft mit ihrer Verletzlichkeit gegen die ideologischen Konventionen der Sprache und ihr sprachlicher Kontrollverlust führt zu einer alternativen, neurodiversen Kommunikation, die auf intensiver Sensitivität beruht.
NatPro LabPro: An innovative laboratory package in plant extract screening for scientific research projects
Authors:   College of Arts and Sciences, Carlos Hilado Memorial State University, Talisay City, Negros Occidental, Philippines, Acanto Ricky B.
Published: June 2024

Challenges in teaching science require innovative approaches—creating new methods and materials to improve student learning experiences. Innovations are essential for national development, fostering growth and positive change. This study focused on developing and evaluating an Innovative Laboratory Package (ILP) designed for science projects in natural product screening. It used a developmental research design and followed the ASSURE instructional model. The study identified that the least common lab tests conducted by students and teachers on natural products included basic pharmacological-toxicological, antioxidant, and cytotoxic assays of plant extracts. Access to laboratory materials and financial support presented moderate challenges for the participants. Laboratory analysts rated the ILP as outstanding, and STEM teachers highly evaluated its content, structure, coherence, learning activities, usefulness, appearance, organization, and innovativeness. Teachers reported that using the ILP provided new, meaningful, and engaging experiences, promoted critical thinking and scientific attitudes, allowed easy and flexible experiments, and equipped students with new scientific skills in a cost-effective way. The ILP could enhance science projects and develop research expertise in plant screening for both students and teachers. The findings can help curriculum developers create innovative learning resources and prioritize curriculum innovations.
Ochrona życia ludzkiego w codziennej egzystencji młodzieży chrześcijańskiej w obliczu cywilizacji śmierci
Authors: Filipiuk Łukasz
Published: June 2024

Artykuł porusza problematykę współczesnego podejścia do aborcji a możliwości kształtowania chrześcijańskiej postawy młodzieży wobec obrony życia. Mając na uwadze fakt, że w dużej mierze współczesne media i opinia publiczna lansują aborcję jako prawo człowieka, naglącą potrzebą wydaje się być wzięcie młodych ludzi pod opiekę przez wskazanie im prawdy dotyczącej początków ludzkiego życia i opowiedzenia się po jej stronie. Wskazanie na Chrystusa jako pełnię życia oraz przywołanie przykładów ludzi świętych ofiarujących swe życie za bliźnich mają zachęcić nastolatków do pójścia ich śladami.
Optimal Systolic Blood Pressure for the Prevention of All-Cause and Cardiovascular Disease Mortality in Older Adults With Hypertension: Nationwide Population-Based Cohort Study
Authors: Lee Jae Jun , Lee Kyung Hee
Published: June 2024

Background

Target systolic blood pressure (SBP) levels for older adults with hypertension vary across countries, leading to challenges in determining the appropriate SBP level.

Objective

This study aims to identify the optimal SBP level for minimizing all-cause and cardiovascular disease (CVD) mortality in older Korean adults with hypertension.

Methods

This retrospective cohort study used data from the National Health Insurance Service database. We included older adults aged 65 years or older who were newly diagnosed with hypertension and underwent a National Health Insurance Service health checkup in 2003-2004. We excluded patients who had a history of hypertension or CVD, were not prescribed medication for hypertension, had missing blood pressure or any other covariate values, and had fewer than 2 health checkups during the follow-up period until 2020. We categorized the average SBP levels into 6 categories in 10 mm Hg increments, from <120 mm Hg to ≥160 mm Hg; 130-139 mm Hg was the reference range. Cox proportional hazards models were used to examine the relationship between SBP and all-cause and CVD mortalities, and subgroup analysis was conducted by age group (65-74 years and 75 years or older).

Results

A total of 68,901 older adults newly diagnosed with hypertension were included in this study. During the follow-up period, 32,588 (47.3%) participants had all-cause mortality and 4273 (6.2%) had CVD mortality. Compared to older adults with SBP within the range of 130-139 mm Hg, individuals who fell into the other SBP categories, excluding those with SBP 120-129 mm Hg, showed significantly higher all-cause and CVD mortality. Subgroup analysis showed that older adults aged 65-74 years had higher all-cause and CVD mortality rates according to SBP categories than those aged 75 years or older.

Conclusions

The SBP levels within the range of 120-139 mm Hg were associated with the lowest all-cause and CVD mortality rates among older Korean adults with hypertension. It is recommended to reduce SBP to <140 mm Hg, with 120 mm Hg as the minimum value for SBP, for older Korean adults with hypertension. Additionally, stricter SBP management is required for adults aged 65-74 years.