bluuebunny/crossref_metadata_2025 huggingface dataset:
A History of Thermodynamics: The Missing Manual
Authors: Saslow Wayne M.
Published: January 2020

We present a history of thermodynamics. Part 1 discusses definitions, a pre-history of heat and temperature, and steam engine efficiency, which motivated thermodynamics. Part 2 considers in detail three heat conservation-based foundational papers by Carnot, Clapeyron, and Thomson. For a reversible Carnot cycle operating between thermal reservoirs with Celsius temperatures t and t + d t , heat Q from the hot reservoir, and net work W, Clapeyron derived W / Q = d t / C ( t ) , with C ( t ) material-independent. Thomson used μ = 1 / C ( t ) to define an absolute temperature but, unaware that an additional criterion was needed, he first proposed a logarithmic function of the ideal gas temperature T g . Part 3, following a discussion of conservation of energy, considers in detail a number of energy conservation-based papers by Clausius and Thomson. As noted by Gibbs, in 1850, Clausius established the first modern form of thermodynamics, followed by Thomson’s 1851 rephrasing of what he called the Second Law. In 1854, Clausius theoretically established for a simple Carnot cycle the condition Q 1 / T 1 + Q 2 / T 2 = 0 . He generalized it to ∑ i Q i / T g , i = 0 , and then ∮ d Q / T g = 0 . This both implied a new thermodynamic state function and, with appropriate integration factor 1 / T , the thermodynamic temperature. In 1865, Clausius named this new state function the entropy S.
Energy Management of a Power System for Economic Load Dispatch Using the Artificial Intelligent Algorithm
Authors: Fu Chao , Zhang Suqi , Chao Kuei-Hsiang
Published: January 2020

Economic Load Dispatch (ELD) is a key issue in power systems and its goal is to achieve minimum economic costs by allocating the output of generator units when satisfying the load demands and the operating constraints. As the dimension of the variables and the constraints increase, the traditional mathematical method is gradually not suitable for the ELD. This paper proposes an Improved Bird Swarm Algorithm (IBSA) to solve the ELD problem of a power system. By introducing the nonlinear cognitive and social coefficients, the proportion of individual learning and social learning of birds can be dynamically adjusted. In addition, the Levy flight strategy is added to the group between producers and beggars to increase the randomness. The performance of IBSA is verified via two systems consisting of 6 and 15 units, respectively, that take into account generation limitation, ramp rate limit, and prohibited operating zones. From the simulation results, the IBSA has shown excellent performance and robustness, which can be considered as a reliable solution for the ELD.
Influence of Lightning Current Model on Simulations of Overvoltages in High Voltage Overhead Transmission Systems
Authors: Furgał Jakub
Published: January 2020

The analysis of lightning overvoltages generated in electrical power systems has a great meaning for the designers and exploitation engineers because it creates bases for the optimization of construction overhead transmission lines and high voltage substations, reducing costs and increasing reliability of the transmission and distribution of electrical energy. Lightning overvoltages generated in electrical power systems with overhead transmission lines are a result of complex, nonlinear, and surge phenomena occurring in the structure of line towers and electrical substation when the lightning current is flowing through them. Methods of overvoltage stress analysis are intensely developed, and one of the directions is working out models of high voltage electrical devices and phenomena in electrical networks, which influence the shape and values of overvoltage risks. The model of lightning current has a significant influence on the courses of overvoltages in high voltage transmission systems. The paper is focused on the analysis of the influence of the model of lightning current making use of simulations of the shape, and maximal values of overvoltages generated in high voltage transmission systems during a direct lightning strike to the overhead lines. Two models of lightning current used in simulations with the Electromagnetic Transients Program/Alternative Transient Program (EMTP/ATP) were analyzed, i.e., the Heidler model and CIGRE (Conseil International des Grands Réseaux Électriques) model. The EMTP/ATP computer program is very often used in simulations of overvoltages in electrical networks. Unfortunately, the users get no information on the criterion to be used when selecting the model of lightning current used in the simulations. The analysis presented in the paper gives practical knowledge about the effect of the use of a particular kind of lightning current model on the results of simulations of lightning overvoltage propagation in electrical networks, overvoltage protection, as well as on theoretical and practical aspects of the insulation coordination in high voltage transmission systems.
Alternative Substrates and Fertilization Doses in the Production of Pinus cembroides Zucc. in Nursery
Authors: Madrid-Aispuro Rosa Elvira , Prieto-Ruíz José Ángel , Aldrete Arnulfo , Hernández-Díaz José Ciro , Wehenkel Christian , Chávez-Simental Jorge Armando , Mexal John G.
Published: January 2020

Rooting substrate and fertilization are key components in the production of containerized seedlings, as they can influence the morphological and physiological characteristics of the plants, which in turn can impact outplanting performance. The objective of the study was to evaluate the effect of four substrates based on mixtures of peat moss (PM), composted bark (CB) and raw pine sawdust (PS), combined with two doses of controlled release fertilizer (CRF) and one non-fertilized control, on the growth of Pinus cembroides Zucc. in the nursery. The treatments were: M1: 50+25+25, M2: 25+25+50, M3: 25+50+25 and M4: 50+50+0 of PM+ CB+ PS (% by volume), respectively. Fertilizer treatments used a controlled release fertilizer (Multicote®): F1: 3 kg m−3 and F2: 6 kg m−3 and a control (WF: with no added fertilizer). The treatments were distributed in a randomized complete block design, with a factorial arrangement of 4 × 3 and six replications. The variables evaluated were: height, seedling diameter, dry biomass, Dickson Quality Index, N, P and K content. Regardless of the substrate, the high fertilizer dose (6 kg m−3) improved most morphological variables. In addition, the high fertilizer dose resulted in foliar N, P and K concentrations within recommended ranges for all substrates. The substrate containing only peat moss and composted bark (M4 + F1 and M4 + F2) had the best growth response. However, the substrate composed of 25% peat moss, 50% composted bark and 25% raw pine sawdust with the high fertilizer dose (M3 + F2) resulted in acceptable seedling growth, and may be preferred if the cost of the substrate is a concern to nursery manager.
Hardwood Species Show Wide Variability in Response to Silviculture during Reclamation of Coal Mine Sites
Authors: Schempf Weston M. , Jacobs Douglass F.
Published: January 2020

Coal is a significant energy source for the United States, and reclamation of surface mined lands is required under the Surface Mining Control and Reclamation Act of 1977. Reforestation of mined lands is challenging due to soil substrate properties including soil compaction, herbaceous competition, and animal browse, necessitating silvicultural treatments to help overcome such limiting factors. We investigated the field performance of black walnut (Juglans nigra L.), northern red oak (Quercus rubra L.), and swamp white oak (Quercus bicolor Willd.) planted on two mine reclamation sites in southern Indiana, USA, and evaluated the interactions of nursery stocktypes (container and bareroot), herbicide application, and tree shelters. Two-year survival averaged 80% across all species and stocktypes. Container stocktype had greater relative height and diameter growth (i.e., relative to initial size at planting), whereas bareroot had greater absolute height and diameter growth corresponding to initial stocktype differences. Shelter use increased height growth and reduced diameter growth across both stocktypes. Swamp white oak (Q. bicolor) had the highest survival rate and field performance regardless of silvicultural treatment, whereas red oak (Q. rubra) and black walnut (J. nigra) showed strong early regeneration responses to silvicultural treatments. Container seedlings showed promise as an alternative to bareroot seedlings to promote early growth on mine reclamation sites. Species-specific responses documented here indicate the need to consider the ecology and stress resistance of target species in developing cost-effective silvicultural prescriptions.
On the Deterministic Prediction of Water Waves
Authors: Klein Marco , Dudek Matthias , Clauss Günther F. , Ehlers Sören , Behrendt Jasper , Hoffmann Norbert , Onorato Miguel
Published: January 2020

This paper discusses the potential of deterministic wave prediction as one basic module for decision support of offshore operations. Therefore, methods of different complexity—the linear wave solution, the non-linear Schrödinger equation (NLSE) of two different orders and the high-order spectral method (HOSM)—are presented in terms of applicability and limitations of use. For this purpose, irregular sea states with varying parameters are addressed by numerical simulations as well as model tests in the controlled environment of a seakeeping basin. The irregular sea state investigations focuses on JONSWAP spectra with varying wave steepness and enhancement factor. In addition, the influence of the propagation distance as well as the forecast horizon is discussed. For the evaluation of the accuracy of the prediction, the surface similarity parameter is used, allowing an exact, quantitative validation of the results. Based on the results, the pros and cons of the different deterministic wave prediction methods are discussed. In conclusion, this paper shows that the classical NLSE is not applicable for deterministic wave prediction of arbitrary irregular sea states compared to the linear solution. However, the application of the exact linear dispersion operator within the linear dispersive part of the NLSE increased the accuracy of the prediction for small wave steepness significantly. In addition, it is shown that non-linear deterministic wave prediction based on second-order NLSE as well as HOSM leads to a substantial improvement of the prediction quality for moderate and steep irregular wave trains in terms of individual waves and prediction distance, with the HOSM providing a high accuracy over a wider range of applications.
Age Distribution, Comorbidities and Risk Factors for Thrombosis in Prader–Willi Syndrome
Authors: Butler Merlin G. , Oyetunji Aderonke , Manzardo Ann M.
Published: January 2020

Prader–Willi syndrome (PWS) is an imprinting disorder caused by lack of expression of the paternally inherited 15q11.2–q13 chromosome region. The risk of death from obesity-related complications can worsen with age, but survival trends are improving. Comorbidities and their complications such as thrombosis or blood clots and venous thromboembolism (VTE) are uncommon but reported in PWS. Two phases of analyses were conducted in our study: unadjusted and adjusted frequency with odds ratios and a regression analysis of risk factors. Individuals with PWS or non-PWS controls with exogenous obesity were identified by specific International Classification of Diseases (ICD)-9 diagnostic codes reported on more than one occasion to confirm the diagnosis of PWS or exogenous obesity in available national health claims insurance datasets. The overall average age or average age per age interval (0–17 year, 18–64 year, and 65 year+) and gender distribution in each population were similar in 3136 patients with PWS and 3945 non-PWS controls for comparison purposes, with exogenous obesity identified from two insurance health claims dataset sources (i.e., commercial and Medicare advantage or Medicaid). For example, 65.1% of the 3136 patients with PWS were less than 18 years old (subadults), 33.2% were 18–64 years old (adults), and 1.7% were 65 years or older. After adjusting for comorbidities that were identified with diagnostic codes, we found that commercially insured PWS individuals across all age cohorts were 2.55 times more likely to experience pulmonary embolism (PE) or deep vein thrombosis (DVT) than for obese controls (p-value: 0.013; confidence interval (CI): 1.22–5.32). Medicaid-insured individuals across all age cohorts with PWS were 0.85 times more likely to experience PE or DVT than obese controls (p-value: 0.60; CI: 0.46–1.56), with no indicated age difference. Age and gender were statistically significant predictors of VTEs, and they were independent of insurance coverage. There was an increase in occurrence of thrombotic events across all age cohorts within the PWS patient population when compared with their obese counterparts, regardless of insurance type.
A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition
Authors: Islam Mohammad S. , Paul Gunther , Ong Hui X. , Young Paul M. , Gu Y. T. , Saha Suvash C.
Published: January 2020

The understanding of complex inhalation and transport processes of pollutant particles through the human respiratory system is important for investigations into dosimetry and respiratory health effects in various settings, such as environmental or occupational health. The studies over the last few decades for micro- and nanoparticle transport and deposition have advanced the understanding of drug-aerosol impacts in the mouth-throat and the upper airways. However, most of the Lagrangian and Eulerian studies have utilized the non-realistic symmetric anatomical model for airflow and particle deposition predictions. Recent improvements to visualization techniques using high-resolution computed tomography (CT) data and the resultant development of three dimensional (3-D) anatomical models support the realistic representation of lung geometry. Yet, the selection of different modelling approaches to analyze the transitional flow behavior and the use of different inlet and outlet conditions provide a dissimilar prediction of particle deposition in the human lung. Moreover, incorporation of relevant physical and appropriate boundary conditions are important factors to consider for the more accurate prediction of transitional flow and particle transport in human lung. This review critically appraises currently available literature on airflow and particle transport mechanism in the lungs, as well as numerical simulations with the aim to explore processes involved. Numerical studies found that both the Euler–Lagrange (E-L) and Euler–Euler methods do not influence nanoparticle (particle diameter ≤50 nm) deposition patterns at a flow rate ≤25 L/min. Furthermore, numerical studies demonstrated that turbulence dispersion does not significantly affect nanoparticle deposition patterns. This critical review aims to develop the field and increase the state-of-the-art in human lung modelling.
Combinations of Epidemiological and Experimental Studies in Air Pollution Research: A Narrative Review
Authors: Weisenberg Hannah , Zhao Tianyu , Heinrich Joachim
Published: January 2020

Scientific literature is evolving to include more systematic reviews that encompass epidemiological and experimental papers so that the whole picture can be examined. The aim of this narrative review is to bridge that gap by combining epidemiological and experimental studies based on the same setting: Examples of Bitterfeld, Utah Valley, Beijing Olympic Games, and Viadana. This review looks at four examples that incorporate multiple epidemiological and experimental papers about air pollution exposure and health effects. The Bitterfeld (spatial) and Utah Valley (temporal) examples showed that particle composition causes the biggest difference in lung injury. In Beijing, a temporal difference of before/after and during the Olympics showed that traffic and industry air pollution-related health effects like lung cancer and cardiovascular disease could be reduced by improvement of air quality. The Viadana example showed a spatial difference in respiratory injury caused by particle composition and interactions with genotoxicity. Combining experimental and epidemiological methods gives a more in-depth look into the whole picture of exposure and health effects. Our review exemplifies the strength of this strategy and encourages further use of it.
An Assessment of the Performance of the PLUS+ Tool in Supporting the Evaluation of Water Framework Directive Compliance in Scottish Standing Waters
Authors: Donnelly David , Helliwell Rachel C. , May Linda , McCreadie Brian
Published: January 2020

Phosphorus is one of the main causes of waterbodies in Scotland being at less than good ecological status (GES) in terms of the water framework directive (WFD). In Scotland, there are more than 8000 standing waters, defined as lakes and reservoirs that have a surface area of more than 1 hectare. Only about 330 of these are monitored routinely to assess compliance with the WFD. The export coefficient tool PLUS+ (phosphorus land use and slope) has been developed to estimate total phosphorus (TP) concentrations in the unmonitored sites; modelled values are then compared to WFD target concentrations for high, good, moderate, poor, and bad status to assess compliance. These type-specific or site-specific targets are set by the regulatory authority and form part of a suite of physical, chemical, and ecological targets that are used to assess GES, all of which must be met. During development, the PLUS+ tool was applied to 323 monitored catchments and 7471 unmonitored catchments. The efficacy of the tool was assessed against TP concentrations observed in 2014 and found to perform well in the rural catchments. 51% of standing waters had the same modelled and observed WFD class (i.e., High, Good, Moderate, Poor, Bad), and a further 40% of standing waters had a modelled WFD class that was within one class of observed water quality. The tool performed less well in catchments with larger inputs of TP from urban sources (e.g., sewage). The greatest deviations between measured and modelled classes were explained by the shortage of information on wastewater treatment works, fish farms, migratory birds, levels of uncertainty in TP measurements, and the amount of in-lake re-cycling of P. The limitations of the tool are assessed using data from six well documented case study sites and recommendations for improving the model performance are proposed.
The Prevalence of Insomnia and the Link between Iron Metabolism Genes Polymorphisms, TF rs1049296 C>T, TF rs3811647 G>A, TFR rs7385804 A>C, HAMP rs10421768 A>G and Sleep Disorders in Polish Individuals with ASD
Authors: Skonieczna-Żydecka Karolina , Jamioł-Milc Dominika , Borecki Krzysztof , Stachowska Ewa , Zabielska Paulina , Kamińska Magdalena , Karakiewicz Beata
Published: January 2020

Iron deficiency have been found to be linked to sleep disorders. Both genetic and environmental factors are risk factors for skewed iron metabolism, thus sleep disruptions in autism spectrum disorders (ASD). The aim of our study was to assess the prevalence of single nucleotide polymorphisms (SNPs) within transferrin gene (TF) rs1049296 C>T, rs3811647 G>A, transferrin receptor gene (TFR) rs7385804 A>C, and hepcidin antimicrobial peptide gene (HAMP) rs10421768 A>G in Polish individuals with ASD and their impact on sleep pattern. There were 61 Caucasian participants with ASD and 57 non-ASD controls enrolled. Genotypes were determined by real-time PCR using TaqMan SNP assays. The Athens Insomnia Scale (AIS) was used to identify sleep disruptions. There were 32 cases (57.14%) with insomnia identified. In the ASD group, the defined counts of genotypes were as follows: TF rs1049296, C/C n = 41 and C/T n = 20; TF rs3811647, G/G n = 22, G/A n = 34, and A/A n = 5; TFR rs7385804, A/A n = 22, A/C n = 29, and C/C n = 10; and HAMP rs10421768, A/A n = 34, A/G n = 23, and G/G n = 4. There were no homozygous carriers of the TF rs1049296 C>T minor allele in the ASD group. All analyzed SNPs were not found to be linked to insomnia. The investigated polymorphisms are not predictors of sleep disorders in the analyzed cohort of individuals with ASD.
Utilization of Waste Polysilicon Sludge in Concrete
Authors: Qudoos Abdul , Jeon In Kyu , Kim Seong Soo , Lee Jeong Bae , Kim Hong Gi
Published: January 2020

Increasing use of cement in the construction industry is causing an alarming increase in carbon dioxide (CO2) emissions, which is a serious environmental threat, it can be reduced by the addition of supplementary cementitious materials (SCMs). The commonly used SCMs like ground granulated blast furnace slag (GGBS), metakaolin (MK) and fly ash (FA) have been successfully used to replace the cement partially or completely. Polysilicon sludge obtained from the photovoltaic industry is also a type of waste material that can be used as SCM because it has high content of reactive SiO2. This study investigates the effects of replacing cement with polysilicon sludge in concrete. Different concrete specimens were made by replacing varying proportions of cement with polysilicon sludge and their properties, such as, fresh properties, compressive strength, heat release, chloride penetration, freeze/thaw resistance and microstructural investigations were determined. The results demonstrate that the polysilicon sludge can be used effectively to replace cement, and environmental threats associated with its disposal can be reduced.
Surface Magnetostriction of FeCoB Amorphous Ribbons Analyzed Using Magneto-Optical Kerr Microscopy
Authors: Hrabovská Kamila , Životský Ondřej , Rojíček Jaroslav , Fusek Martin , Mareš Vratislav , Jirásková Yvonna
Published: January 2020

Surface sensitive magneto-optical Kerr microscopy completed with the special self-made sample holder is used for studying the magneto-elastic behaviour in the surface of the as-quenched amorphous Fe73Co12B15 alloy. The 10, 5, and 3 mm wide and approximately 34 μm thick ribbons were prepared by the conventional planar flow casting process. The experimental setup allows for a simultaneous application of an external magnetic field in the directions parallel and perpendicular to the ribbon axis and of compression stress from one side of the sample, resulting in tensile stress in opposite side. The distributions of tensile stresses in the measured surface were modelled by the finite element method. The observed changes of the magnetic domains and hysteresis loop anisotropy field under applied stress are evaluated using the Becker–Kersten method. This resulted in the determination of the local surface magnetostrictive coefficient from an area of about 200 μm in diameter. The obtained values ranged between 37–60 ppm and were well comparable with the bulk value presented in the literature.
A Review of Non-Soil Biochar Applications
Authors: Bartoli Mattia , Giorcelli Mauro , Jagdale Pravin , Rovere Massimo , Tagliaferro Alberto
Published: January 2020

Biochar is the solid residue that is recovered after the thermal cracking of biomasses in an oxygen-free atmosphere. Biochar has been used for many years as a soil amendment and in general soil applications. Nonetheless, biochar is far more than a mere soil amendment. In this review, we report all the non-soil applications of biochar including environmental remediation, energy storage, composites, and catalyst production. We provide a general overview of the recent uses of biochar in material science, thus presenting this cheap and waste-derived material as a high value-added and carbonaceous source.
A Novel Method for Improving Weld Seam Properties through Inline Coupling of Welding and Forming
Authors: Härtel Sebastian , Adams Tom-Eric , Hoefer Kevin , Awiszus Birgit , Mayr Peter
Published: January 2020

High heat input during welding leads to transformations of the microstructure in the area subjected to welding, mostly resulting in an inhomogeneous microstructure and an overall deterioration of the mechanical properties. To restore these properties, post treatment processes which are typically separated from the welding process are state of the art. The present work focusses on recrystallization phenomena and shows the new methodology, WeldForming, which intends to eliminate subsequent treatment processes. The new inline process combination harnesses the synergies of a welding and a rolling process to ultimately prevent the typical zone formation of the heat affected zone. This is done by stimulating recrystallization and recovery processes. The development of the process is based on numerical simulations. A new aspect is the first time coupling of both processes in a single simulation model. The required material models were generated with the aid of thermophysical simulations. A novel approach is shown for creating a material model for the filler metal G4Si1 with the typical directed solidification microstructure. On the basis of the gained knowledge out of thermomechanical and numerical simulation, a process window was identified and a test setup was developed which gave the functional prove of the WeldForming process.
AFM Analyses of 3XXX Series Al Alloy Reinforced with Different Hard Nanoparticles Produced in Liquid State
Authors: Gallegos-Orozco Verónica , Santos-Beltrán Audel , Santos-Beltrán Miriam , Estrada-Guel Ivanovich , Ronquillo-Ornelas Iza , Brito-Chaparro José , Carbajal-Sanchez Ricardo
Published: January 2020

In the present work, nanocomposites-based 3XXX series Al alloy with three different types of hard nanoparticles, including TiO2, C, and CeO2, were produced employing two techniques such as mechanical milling and stir-casting method in order to evaluate the viability of integration of the reinforcement in the Al matrix. The integration and dispersion capability of the reinforcement into the Al alloy (3xxx Series) matrix was evaluated, using a phase angle difference and surface roughness analyses by atomic force microscopy operated in both the contact mode (CM-AFM) and tapping mode (TM-AFM), respectively. The distribution profile of both rugosity and the phase angle shift was used to statically quantify the integration and dispersion of the reinforcement into the extruded samples, by using the root mean square (RMS) parameter and phase shift coupled with the events number (EN) parameter. Results from Atomic Force Microscopy (AFM) analyses were corroborated by X-ray diffractometry and scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Microhardness tests were conducted to identify the mechanical properties of the composites in the extruded condition and their correlation with the microstructure. A close relationship was found between the microstructure obtained from the AFM and X-ray diffractometry (XRD) analyses and mechanical properties. Among all, the C reinforcement produced the major changes in the microstructure as well as the best integration and dispersion into the Al-alloy coupled with the best mechanical properties.
Composite Hurwitz Rings as PF-Rings and PP-Rings
Authors: Kim Dong Kyu , Lim Jung Wook
Published: January 2020

Let R ⊆ T be an extension of commutative rings with identity and H ( R , T ) (respectively, h ( R , T ) ) the composite Hurwitz series ring (respectively, composite Hurwitz polynomial ring). In this article, we study equivalent conditions for the rings H ( R , T ) and h ( R , T ) to be PF-rings and PP-rings. We also give some examples of PP-rings and PF-rings via the rings H ( R , T ) and h ( R , T ) .
Distribution, Contents, and Types of Mycosporine-Like Amino Acids (MAAs) in Marine Macroalgae and a Database for MAAs Based on These Characteristics
Authors: Sun Yingying , Zhang Naisheng , Zhou Jing , Dong Shasha , Zhang Xin , Guo Lei , Guo Ganlin
Published: January 2020

Mycosporine-like amino acids (MAAs), maximally absorbed in the wavelength region of 310–360 nm, are widely distributed in algae, phytoplankton and microorganisms, as a class of possible multi-functional compounds. In this work, based on the Web of Science, Springer, Google Scholar, and China national knowledge infrastructure (CNKI), we have summarized and analyzed the studies related to MAAs in marine macroalgae over the past 30 years (1990–2019), mainly focused on MAAs distribution, contents, and types. It was confirmed that 572 species marine macroalgae contained MAAs, namely in 45 species of Chlorophytes, 41 species of Phaeophytes, and 486 species of Rhodophytes, and they respectively belonged to 28 orders. On this basis, we established an open online database to quickly retrieve MAAs in 501 species of marine macroalgae. Furthermore, research concerning MAAs in marine macroalgae were analyzed using CiteSpace. It could easily be seen that the preparation and purification of MAAs in marine macroalgae have not been intensively studied during the past 10 years, and therefore it is necessary to strengthen the research in the preparation and purification of MAA purified standards from marine macroalgae in the future. We agreed that this process is not only interesting, but important due to the potential use of MAAs as food and cosmetics, as well as within the medicine industry.
Pain and Function in the Runner a Ten (din) uous Link
Authors: Francis Peter , Thornley Isobel , Jones Ashley , I. Johnson Mark
Published: January 2020

A male runner (30 years old; 10-km time: 33 min, 46 s) had been running with suspected insertional Achilles tendinopathy (AT) for ~2 years when the pain reached a threshold that prevented running. Diagnostic ultrasound (US), prior to a high-volume stripping injection, confirmed right-sided medial insertional AT. The athlete failed to respond to injection therapy and ceased running for a period of 5 weeks. At the beginning of this period, the runner completed the Victoria institute of sports assessment–Achilles questionnaire (VISA-A), the foot and ankle disability index (FADI), and FADI sport prior to undergoing an assessment of bi-lateral gastrocnemius medialis (GM) muscle architecture (muscle thickness (MT) and pennation angle (PA); US), muscle contractile properties (maximal muscle displacement (Dm) and contraction time (Tc); Tensiomyography (TMG)) and calf endurance (40 raises/min). VISA-A and FADI scores were 59%/100% and 102/136 respectively. Compared to the left leg, the right GM had a lower MT (1.60 cm vs. 1.74 cm), a similar PA (22.0° vs. 21.0°), a lower Dm (1.2 mm vs. 2.0 mm) and Tc (16.5 ms vs. 17.7 ms). Calf endurance was higher in the right leg compared to the left (48 vs. 43 raises). The athlete began a metronome-guided (15 BPM), 12-week progressive eccentric training protocol using a weighted vest (1.5 kg increments per week), while receiving six sessions of shockwave therapy concurrently (within 5 weeks). On returning to running, the athlete kept daily pain (Numeric Rating Scale; NRS) and running scores (miles*rate of perceived exertion (RPE)). Foot and ankle function improved according to scores recorded on the VISA-A (59% vs. 97%) and FADI (102 vs. 127/136). Improvements in MT (1.60 cm vs. 1.76 cm) and PA (22.0° vs. 24.8°) were recorded via US. Improvements in Dm (1.15 mm vs. 1.69 mm) and Tc (16.5 ms vs. 15.4 ms) were recorded via TMG. Calf endurance was lower in both legs and the asymmetry between legs remained (L: 31, R: 34). Pain intensity (mean weekly NRS scores) decreased between week 1 and week 12 (6.6 vs. 2.9), while running scores increased (20 vs. 38) during the same period. The program was maintained up to week 16 at which point mean weekly NRS was 2.2 and running score was 47.
Gross Hematuria as a Presenting Feature of Posterior Urethral Valves in a Neonate with Normal Antenatal Sonograms
Authors: Acharya Ratna , DeMarco Romano , Upadhyay Kiran
Published: January 2020

Background: Posterior urethral valves (PUVs) are usually suspected during antenatal sonograms or by postnatal evidence of bilateral hydronephrosis with enlarged bladder. Gross hematuria as an initial manifestation of PUV with a history of normal antenatal sonogram is very rare. Methods: This is a retrospective chart study. Results: We describe a nine-day-old male neonate who presented with gross hematuria and was later found to have a urinary tract infection (UTI) and severe acute kidney injury (AKI). The mother apparently had normal antenatal sonograms with no evidence of fetal hydronephrosis. The child did not have postnatal renal bladder sonogram done until gross hematuria occurred at Day 9 of life. Sonogram showed bilateral severe hydronephrosis and hydroureter with enlarged bladder. The patient underwent ablation of the PUVs after initial bladder decompression with indwelling urethral catheterization. His AKI resolved after prompt treatment of UTI and PUV ablation. Conclusions: This report emphasizes the importance of a high index of suspicion for obstructive uropathy in a newborn with gross hematuria irrespective of prenatal sonogram findings.
T-Channel Field Effect Transistor with Three Input Terminals (Ti-TcFET)
Authors: Chen Zeqi , Hu Jianping , Ye Hao , Chu Zhufei
Published: January 2020

In this paper, a novel T-channel field effect transistor with three input terminals (Ti-TcFET) is proposed. The channel of a Ti-TcFET consists of horizontal and vertical sections. The top gate is above the horizontal channel, while the front gate and back gate are on either side of the vertical channel. The T-shaped channel structure increases the coupling area between the top gate and the front and back gates, which improves the ability of the gate electrodes to control the channel. What’s more, it makes the top gate have almost the same control ability for the channel as the front gate and the back gate. This unique structure design brings a unique function in that the device is turned on only when two or three inputs are activated. Silvaco technology computer-aided design (TCAD) simulations are used to verify the current characteristics of the proposed Ti-TcFET. The current characteristics of the device are theoretically analyzed, and the results show that the theoretical analysis agrees with the TCAD simulation results. The proposed Ti-TcFET devices with three input terminals can be used to simplify the complex circuits in a compact style with reduced counts of transistors compared with the traditional complementary metal–oxide–semiconductor/ fin field-effect transistors (CMOS/FinFETs) with a single input terminal and thus provides a new idea for future circuit designs.
A 45 nm CMOS Avalanche Photodiode with 8.4-GHz Bandwidth
Authors: Zhi Wenhao , Quan Qingxiao , Yu Pingping , Jiang Yanfeng
Published: January 2020

Photodiode is one of the key components in optoelectronic technology, which is used to convert optical signal into electrical ones in modern communication systems. In this paper, an avalanche photodiode (APD) is designed and fulfilled, which is compatible with Taiwan Semiconductor Manufacturing Company (TSMC) 45-nm standard complementary metal–oxide–semiconductor (CMOS) technology without any process modification. The APD based on 45 nm process is beneficial to realize a smaller and more complex monolithically integrated optoelectronic chip. The fabricated CMOS APD operates at 850 nm wavelength optical communication. Its bandwidth can be as high as 8.4 GHz with 0.56 A/W responsivity at reverse bias of 20.8 V. Its active area is designed to be 20 × 20 μm2. The Simulation Program with Integrated Circuit Emphasis (SPICE) model of the APD is also proposed and verified. The key parameters are extracted based on its electrical, optical and frequency responses by parameter fitting. The device has wide potential application for optical communication systems.
Micro Electrochemical Machining of Array Micro-Grooves Using In-Situ Disk Electrode Fabricated by Micro-WEDM
Authors: Wang Yukui , Wang Han , Zhang Yuxin , He Xiaolong , Wang Zhenlong , Chi Guanxin , Chen Xiang , Song Mingshan
Published: January 2020

This paper develops an array micro-grooves manufacturing method using micro electrochemical machining (ECM) with disk electrode, which is prepared by in-situ micro wire electrical discharge machining (WEDM). This technology focuses on the difficulty of array structure manufacture in micro-electro-mechanical systems (MEMS). A micro-ECM system is built based on the micro-WEDM machine to achieve high precision processing of the array micro-grooves. Since micro-WEDM has good performance in high precision machining of the rotating structure, single and multi-edge disk electrodes can be fabricated in-situ using graphite. The as-prepared disk tool electrode is directly used for micro-electrochemical milling of the array micro-grooves without disassembling away from the device, which avoids the positioning error caused by the re-clamping of the disk electrode. With the advantages of high surface quality and no electrode loss, micro-ECM improves the manufacture performance of the micro-parts. Through wire path optimization, the shape accuracy of the disk edge is improved. After the research of the micro-ECM parameters, the process is improved, and finally, the high precision array micro-grooves are obtained. This method combines the advantages of micro-WEDM and disk electrode micro-ECM milling, and it is convenient for large-scale manufacture of array micro-structures on micro-parts and MEMS.
Rare Earth Element Determination in Uranium Ore Concentrates Using Online and Offline Chromatography Coupled to ICP-MS
Authors: Bradley Veronica C. , Manard Benjamin T. , Roach Benjamin D. , Metzger Shalina C. , Rogers Kayron T. , Ticknor Brian W. , Wysor Sarah K. , Brockman John D. , Hexel Cole R.
Published: January 2020

The determination of trace elements, particularly rare earth elements, in uranium ore concentrates (UOCs) is important as the pattern can be indictive ore characteristics. Presented here is a methodology for accurately quantifying rare earth elements (REE) in UOCs. To improve the measurement uncertainty, isotope dilution mass spectrometry (IDMS) was utilized over other quantification techniques such as external calibration or standard addition. The isotopic determinations were measured by inductively coupled plasma-mass spectrometry (ICP-MS). To obtain high-fidelity isotopic measurements, separation of the REE from the uranium matrix was achieved by high-performance ion chromatography (HPIC), reducing the isobaric interferences. After separation, the target analytes were analyzed in two different modalities. For high precision analysis, the separated analytes were collected and measured by ICP-MS in an “offline” fashion. For a rapid approach, the separated analytes were sent directly into an ICP-MS for “online” analysis. These methods have been demonstrated to accurately quantify the REE content in a well-characterized UOC sample.
Ag Nanoparticles Stabilized on Cyclodextrin Polymer Decorated with Multi-Nitrogen Atom Containing Polymer: An Efficient Catalyst for the Synthesis of Xanthenes
Authors: Sadjadi Samahe , Ghoreyshi Kahangi Fatemeh , Dorraj Masoumeh , Heravi Majid M.
Published: January 2020

In attempt to broaden the use of cyclodextrin polymer for catalytic purposes, a novel covalent hybrid system was prepared through growth of multi-nitrogen atom containing polymer (PMelamine) derived from reaction of ethylenediamine and 2,4,6-trichloro-1,3,5-triazine on the functionalized cyclodextrin polymer (CDNS). The resulting hybrid system was then utilized as a catalyst support for the immobilization of silver nanoparticles through using Cuscuta epithymum extract as a naturally-derived reducing agent. The catalytic activity of the catalyst, Ag@CDNS-N/PMelamine, for the synthesis of xanthenes through reaction of aldehydes and dimedone in aqueous media was examined. The results showed high catalytic activity and recyclability of the catalyst. It was believed that cyclodextrin in the backbone of the catalyst could act both as a capping agent for Ag nanoparticles and phase transfer agent to bring the hydrophobic substrates in the vicinity of the catalytic active sites and accelerate the reaction rate. Multi-nitrogen atoms on the polymer, on the other hand, could improve the Ag NPs anchoring and suppress their leaching.
UV/Vis Light Induced Degradation of Oxytetracycline Hydrochloride Mediated by Co-TiO2 Nanoparticles
Authors: Akel Soukaina , Boughaled Redouan , Dillert Ralf , El Azzouzi Mohamed , Bahnemann Detlef W.
Published: January 2020

Pharmaceuticals, especially antibiotics, constitute an important group of aquatic contaminants given their environmental impact. Specifically, tetracycline antibiotics (TCs) are produced in great amounts for the treatment of bacterial infections in both human and veterinary medicine. Several studies have shown that, among all antibiotics, oxytetracycline hydrochloride (OTC HCl) is one of the most frequently detected TCs in soil and surface water. The results of the photocatalytic degradation of OTC HCL in aqueous suspensions (30 mg·L−1) of 0.5 wt.% cobalt-doped TiO2 catalysts are reported in this study. The heterogeneous Co-TiO2 photocatalysts were synthesized by two different solvothermal methods. Evonik Degussa Aevoxide P25 and self-prepared TiO2 modified by the same methods were used for comparison. The synthesized photocatalysts were characterized by X-ray powder diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), UV/vis diffuse reflectance spectroscopy (DRS), and N2 adsorption (BET) for specific surface area determination. The XRD and Raman results suggest that Ti4+ was substituted by Co2+ in the TiO2 crystal structure. Uv/visible spectroscopy of Co-TiO2-R showed a substantial redshift in comparison with bare TiO2-R. The photocatalytic performance of the prepared photocatalysts in OTC HCL degradation was investigated employing Uv/vis spectroscopy and high-performance liquid chromatography (HPLC). The observed initial reaction rate over Co-TiO2-R was higher compared with that of Co-TiO2-HT, self-prepared TiO2, and the commercial P25. The enhanced photocatalytic activity was attributed to the high surface area (153 m2·g−1) along with the impurity levels within the band gap (2.93 eV), promoting the charge separation and improving the charge transfer ability. From these experimental results, it can be concluded that Co-doping under reflux demonstrates better photocatalytic performances than with the hydrothermal treatment.
Simultaneous Quantitation of S(+)- and R(−)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC–APCI–MS/MS: An Application for Clinical Studies
Authors: He Qingfeng , Chhonker Yashpal S. , McLaughlin Matthew J. , Murry Daryl J.
Published: January 2020

Baclofen is a racemic mixture that is commonly used for the treatment for spasticity. However, the optimal dose and dosing interval to achieve effective cerebral spinal fluid (CSF) concentrations of baclofen are not known. Moreover, it is unclear if there are differences in the ability of R- or S-baclofen to cross the blood–brain barrier and achieve effective CSF concentrations. We have validated a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method with improved selectivity and sensitivity for the simultaneous quantitation of R- and S-baclofen and metabolites in plasma and CSF. Protein precipitation by acetonitrile was utilized to obtain an acceptable recovery of the analytes. The detection and separation of analytes was achieved on a 48 °C-heated Crownpak CR(+) column (150 mm × 4.0 mm, 5μ) with elution using 0.4% formic acid (FA) in water and 0.4% FA in acetonitrile as the mobile phase running at a flow rate of 1.0 mL/min. Accurate quantitation was assured by using this MS/MS method with atmospheric pressure chemical ionization in multiple reaction monitoring (MRM) mode. Therefore, this method is enantioselective, accurate, precise, sensitive, reliable, and linear from 1 to 1500 ng/mL for baclofen and 2 to 4000 ng/mL for the metabolites. An additional method was developed to separate racemic baclofen 3-(4-chlorophenyl)-4 hydroxybutyric acid metabolites for individual concentration determination. Both validated methods were successfully applied to a clinical pharmacokinetic human plasma and CSF study evaluating the disposition of baclofen and metabolites.
Discharging Women with Advanced Ovarian Cancer on Home Parenteral Nutrition: Making and Implementing the Decision
Authors: Sowerbutts Anne Marie , Lal Simon , Sremanakova Jana , Clamp Andrew R. , Jayson Gordon C. , Teubner Antje , Hardy Lisa , Todd Chris , Raftery Anne-Marie , Sutton Eileen , Burden Sorrel
Published: January 2020

Increasingly, patients with advanced ovarian cancer in bowel obstruction are receiving home parenteral nutrition (HPN). Little is known about making and implementing the decision. This study explored the decision-making process for HPN and investigated the barriers and facilitators to implementation. This was a qualitative study underpinned by phenomenology involving 93 longitudinal in-depth interviews with 20 patients, their relatives and healthcare professionals, over 15 months. Participants were interviewed a maximum of four times. Interview transcripts were analysed thematically as per the techniques of Van Manen. We found variance between oncologists and patients regarding ownership of the HPN decision. The oncologists believed they were engaging in a shared decision-making process. However, patients felt that the decision was oncologist-driven. Nevertheless, they were content to have the treatment, when viewing the choice as either HPN or death. In implementing the decision, the principal mutable barrier to a timely discharge was communication difficulties across professional disciplines and organisations. Facilitators included developing a single point-of-contact between organisations, improving communication and implementing standardised processes. Oncologists and patients differ in their perceptions of how treatment decisions are made. Although patients are satisfied with the process, it might be beneficial for healthcare professionals to check patients’ understanding of treatment.
In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin
Authors: Jørgensen Jacob Rune , Yu Feiyang , Venkatasubramanian Ramakrishnan , Nielsen Line Hagner , Nielsen Hanne Mørck , Boisen Anja , Rades Thomas , Müllertz Anette
Published: January 2020

Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with unidirectionally releasing microcontainers (MCs) has previously been shown to increase insulin permeation across Caco-2 cell monolayers. In the present work, this setup was further employed to compare three common PEs—sodium caprate (C10), sodium dodecyl sulfate (SDS), and lauroyl carnitine. The concept was also studied using porcine intestinal tissue with the inclusion of 70 kDa fluorescein isothiocyanate-dextran (FD70) as a pathogen marker. Moreover, a combined proteolysis and Caco-2 cell permeation setup was developed to investigate the effect of soybean trypsin inhibitor (STI) in the MCs. Lastly, in vivo performance of the MCs was tested in an oral gavage study in rats by monitoring blood glucose and insulin absorption. SDS proved to be the most potent PE without increasing the ex vivo uptake of FD70, while the implementation of STI further improved insulin permeation in the combined proteolysis Caco-2 cell setup. However, no insulin absorption in rats was observed upon oral gavage of MCs loaded with insulin, PE and STI. Post-mortem microscopic examination of their gastrointestinal tract indicated lack of intestinal retention and optimal orientation by the MCs, possibly precluding the potential advantage of unidirectional release.