bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Acupuncture on Postoperative Pain in Patients after Laparoscopic Cholecystectomy: A Randomized Clinical Trial
Authors: Wang Fengxiao , Peng Pinwei , Zheng Yixin , Cheng Shuqun , Chen Yunfei
Published: January 2023

Objective. To evaluate the efficacy and safety of acupuncture compared to that of parecoxib sodium on postoperative pain (POP), postoperative nausea and vomiting (PONV), and the Bruggemann Comfort Scale (BCS) in patients following laparoscopic cholecystectomy (LC). Methods. Eligible patients admitted to the hospital for LC were randomly allocated to either acupuncture or control groups in a 1 : 1 ratio. The subjects in the acupuncture group received acupuncture while those in the control group were injected by parecoxib sodium at their requests. The pain score, PONV score, and BCS were assessed at 0 h, 6 h, 9 h, and 12 h after operation. The primary outcome was the pain score. The secondary outcomes included the number of patients asking for parecoxib sodium from the two groups at 0–6 h and 6–12 h, PONV score, and BCS score. Results. The pain score of the acupuncture group were lower in acupuncture than that in the control group at 6 h and 9 h after operation (P = 0.002, P = 0.008). However, no difference was found at 12 h. Besides, the number of patients administered parecoxib sodium in acupuncture group was less than that in the control group both at 0–6 h and 6–12 h after operation (P = 0.019, P < 0.001). Similarly, there were significantly lower levels of PONV score and higher levels of BCS at 6 h after operation in the acupuncture group than in the control group. However, no difference was found at 9 h and 12 h. Conclusion. Acupuncture can clinically improve the short‐term treatment of postoperative pain after LC and reduce the request for extra analgesics; therefore, acupuncture might be a potential method as one of multimodal analgesia techniques to treat POP following LC. Trial Registrations. This trial is registered with ChiCTR2000036885 (Chinese Clinical Trial Registry).
Fuzzy Spectral Spaces and Fuzzy Congruences of a Heyting ADL
Authors: Gubena Yeshiwas Mebrat , Alemayehu Teferi Getachew
Published: January 2023

In this paper, the space

F

p

of fuzzy prime ideals of Heyting almost distributive lattice

H

is studied, and it is shown that the collection of all sets

M

η

is a topology on

F

p

, where

η

is a fuzzy ideal on

H

and

M

η

=

θ
∈

F

p

|

η
⊈
θ

. The only compact subset of the space

F

p

is given. A fuzzy congruence relation

Θ

on

H

is defined, and the homomorphism between the set of all fuzzy ideals of

H

and the set of all fuzzy ideals of

H
/
Θ

is established. Furthermore, we established an isomorphism between fuzzy spectrum of

H

and fuzzy spectrum of

H
/
Θ

.
[Retracted] Circular RNA SMARCA5 Modulates Epithelial‐Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA‐582‐3p/Phosphatase and Tensin Homolog Axis
Authors: Wang Hui , Ren HaiTang
Published: January 2023

The action mechanism in which circular RNA (circ) SMARCA5 targeted nasopharyngeal carcinoma (NPC) cell proliferation, migration, invasion, and apoptosis via microRNA (miR)‐582‐3p/phosphatase and tensin homolog (PTEN) axis was explored. The examination was performed via reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR), discovering that circSMARCA5 was elevated while miR‐582‐3p was silenced in NPC tissues and cells. E‐cadherin and N‐cadherin were detected. The results illustrated transfection with si‐circSMARCA5 or miR‐582‐3p‐mimic was available to repress cancer cell advancement, and E‐cadherin was augmented. Transfection with pcDNA 3.1‐circSMARCA5 or miR‐582‐3p‐inhibitor was available to accelerate cancer cell advancement, and N‐cadherin was augmented. MiR‐582‐3p‐inhibitor blocked the suppression of si‐circSMARCA5 on NPC. The si‐PTEN blocked the malignant behavior of pcDNA 3.1‐circSMARCA5 against NPC. The binding sites between circSMARCA5 and miR‐582‐3p and between miR‐582‐3p and PTEN were verified. Linear analysis results illuminated the expression pattern of circSMARCA5 was opposite to miR‐582‐3p, while the expression pattern of circSMARCA5 was positively associated with PTEN. In brief, the results of the research clarified circSMARCA5 modulated NPC cells’ vital movement via the miR‐582‐3p/PTEN molecular axis.
Epoxy–Date Palm Fiber Composites: Study on Manufacturing and Properties
Authors: Ali Malek
Published: January 2023

Epoxy-date palm fiber (DPF) composites have been synthesized and characterized successfully with various reinforced ratios of DPF (i.e., 5, 10, 15, and 20 wt%), where the mixture of Epoxy–DPF is poured into different prepared silicone molds. The first type of silicon molds is prepared to produce the samples of the Epoxy–DPF composites to conduct mechanical tests (i.e., impact, creep, and tensile). When the ratio of DPF is increased in the Epoxy matrix, a significant improvement was observed in the results of the mechanical tests. The Epoxy–DPF composites with 15 wt% exhibit a high hardness of 38.4 in comparison with other composite specimens. Maximum impact strength, creep strain, and tensile strengths were recorded to be 0.13 J/mm2, 0.03112, and 23.4 N/mm2, respectively, using 20 wt% DPF.
Effect of Teriparatide on Bone Mineral Density and Bone Markers in Real-Life: Argentine Experience
Authors: Guelman Rodolfo , Sánchez Ariel , Varsavsky Mariela , Brun Lucas R. , García María Laura , Sarli Marcelo , Paula Rey , Farias Vanina , Zanchetta María Belén , Giacoia Evangelina , Salerni Helena , Maffei Laura , Premrou Valeria , Oliveri Beatriz , Brance María Lorena , Pavlove Magdalena , Karlsbrum Silvia , Larroudé María Silvia , Costanzo Pablo René
Published: January 2023

Purpose. To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials. Methods. Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months. Results. 264 patients were included in the study. Main characteristics are as follows: age: 68.7 ± 10.2 years, previous fractures: 57.6%, and previously treated with antiresorptive (AR-prior): 79%. All bone turnover markers studied significantly increased after 6 months. CTX and BGP remained high up to 24 months, but total and bone alkaline phosphatase returned to basal values at month 18. There was a significant increase in lumbar spine (LS) BMD after 6 months (+6.2%), with a maximum peak at 24 months (+13%). Femoral neck (FN) and total hip (TH) BMD showed a significant increase later than LS (just at month 12), reaching a maximum peak at month 24 (FN + 7.9% and TH + 5.5%). A significant increase in LS BMD was found from month 6 to month 24 compared to basal in both AR-naïve, and AR-prior patients (+16.7% and +10.5%, respectively), without significant differences between the two groups. Comparable results were found in FN and TH BMD. Main conclusions. As reported in real-life clinical studies, treatment of osteoporotic postmenopausal women with TPTD induced a significant increase in bone turnover markers from month 6 onward and an increase in BMD from months 6–12 with continuous gain up to month 24. The real-life results of our study matched the results of randomized clinical trials. In addition, TPTD induced an increase in BMD, regardless of the previous use of AR.
Violence against Emergency Nurses in Kermanshah-Iran: Prevalence and Associated Factors
Authors: Janatolmakan Maryam , Abdi Alireza , Rezaeian Shahab , Framarzi Nasab Negin , Khatony Alireza
Published: January 2023

Background. Violence against emergency nurses is a global concern with undesirable physical and psychological consequences. This study was conducted to investigate the characteristics of physical and verbal violence against emergency nurses in Iran. Methods. In this cross-sectional study, 150 nurses working in seven hospitals affiliated to Kermanshah University of Medical Sciences were included in the study using the stratified random sampling method. The data collection tools included a personal information form and a researcher-made questionnaire. Violence-related characteristics were assessed using descriptive statistics. Logistic regression was used to identify factors related to physical and verbal violence. Results. The frequency rates of physical and verbal violence during the past 12 months were equal to 62% (n = 93) and 94.7% (n = 142), respectively. In both types of physical violence (49.5%, n = 46) and verbal violence (40.4%, n = 57), the nursing station was the most common place of violence. In both physical (n = 40, 43.0%) and verbal violence (n = 101, 71.1%), the most common perpetrator was the patient’s family. Most physical violence (57.0%, n = 53) and verbal violence (35.2%, n = 50) occurred in the night shifts. No statistically significant relationship was found between physical and verbal violence and gender, age, marital status, type of employment, and work experience. Discussion. The results indicate the seriousness of workplace violence against nurses. It is necessary to adopt a global approach along with providing sufficient manpower and psychological empowerment of nurses. Further studies with a forward-looking approach are suggested.
Collagens in Cancer: Structural Regulators and Guardians of Cancer Progression
Authors: De Martino Daniela , Bravo-Cordero Jose Javier
Published: January 2023

Collagen is one of the most abundant proteins in animals and a major component of the extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of tissues, collagens can modulate the behavior of cells, and their deregulation can promote diseases such as cancer. In tumors, collagens and many other ECM molecules are mainly produced by fibroblasts, and recent evidence points toward a role of tumor-derived collagens in tumor progression and metastasis. In this review, we focus on the newly discovered functions of collagens in cancer. Novel findings have revealed the role of collagens in tumor dormancy and immune evasion, as well as their interplay with cancer cell metabolism. Collagens could serve as prognostic markers for patients with cancer, and therapeutic strategies targeting the collagen ECM have the potential to prevent tumor progression and metastasis.
ASPM Activates Hedgehog and Wnt Signaling to Promote Small Cell Lung Cancer Stemness and Progression
Authors: Cheng Li-Hsin , Hsu Chung-Chi , Tsai Hung-Wen , Liao Wen-Ying , Yang Pei-Ming , Liao Tai-Yan , Hsieh Hsiao-Yen , Chan Tze-Sian , Tsai Kelvin K.
Published: January 2023

Small cell lung cancer (SCLC) is among the most aggressive and lethal human malignancies. Most patients with SCLC who initially respond to chemotherapy develop disease relapse. Therefore, there is a pressing need to identify novel driver mechanisms of SCLC progression to unlock treatment strategies to improve patient prognosis. SCLC cells comprise subsets of cells possessing progenitor or stem cell properties, while the underlying regulatory pathways remain elusive. Here, we identified the isoform 1 of the neurogenesis-associated protein ASPM (ASPM-I1) as a prominently upregulated stemness-associated gene during the self-renewal of SCLC cells. The expression of ASPM-I1 was found to be upregulated in SCLC cells and tissues, correlated with poor patient prognosis, and indispensable for SCLC stemness and tumorigenesis. A reporter array screening identified multiple developmental signaling pathways, including Hedgehog (Hh) and Wnt pathways, whose activity in SCLC cells depended upon ASPM-I1 expression. Mechanistically, ASPM-I1 stabilized the Hh transcriptional factor GLI1 at the protein level through a unique exon-18–encoded region by competing with the E3 ligases β-TrCP and CUL3. In parallel, ASPM-I1 sustains the transcription of the Hh pathway transmembrane regulator SMO through the Wnt−DVL3−β-catenin signaling axis. Functional studies verified that the ASPM-I1–regulated Hh and Wnt activities significantly contributed to SCLC aggressiveness in vivo. Consistently, the expression of ASPM-I1 positively correlated with GLI1 and stemness markers in SCLC tissues. This study illuminates an ASPM-I1–mediated regulatory module that drives tumor stemness and progression in SCLC, providing an exploitable diagnostic and therapeutic target.

Significance:

ASPM promotes SCLC stemness and aggressiveness by stabilizing the expression of GLI1, DVL3, and SMO, representing a novel regulatory hub of Hh and Wnt signaling and targetable vulnerability.
Research Silos in Cancer Disparities: Obstacles to Improving Clinical Outcomes for Underserved Patient Populations
Authors: Richardson Angelique , Darst Burcu , Wojcik Genevieve , Wagle Nikhil , Haricharan Svasti
Published: January 2023

Despite much vaunted progress in cancer therapeutics and diagnostics, outcomes for many groups of non-White patients with cancer remain worse than those for their White compatriots. One reason for this is the lack of inclusion and representation of non-White patients in clinical trials, preclinical datasets, and among researchers, a shortfall that is gaining wide recognition within the cancer research community and the lay public. Several reviews and editorials have commented on the negative impacts of the status quo on progress in cancer research toward medical breakthroughs that help all communities and not just White patients with cancer. In this perspective, we describe the existence of research silos focused either on the impact of socioeconomic factors proceeding from systemic racism on cancer outcomes, or on genetic ancestry as it affects the molecular biology of cancer developing in specific patient populations. While both these research areas are critical for progress toward precision medicine equity, breaking down these silos will help us gain an integrated understanding of how race and racism impact cancer development, progression, and patient outcomes. Bringing this comprehensive approach to cancer disparities research will undoubtedly improve our overall understanding of how stress and environmental factors affect the molecular biology of cancer, which will lead to the development of new diagnostics and therapeutics that are applicable across cancer patient demographics.
Overweight and Obesity in Brazilian Immigrants in Massachusetts, USA: A Time Series Analysis (2009–2020)
Authors: Paixão Talita Monsores , Siqueira Carlos Eduardo Gomes , Tristan-Cheever Elisa , Fischer Frida Marina , Martinez Maria Carmen , Christoffolete Marcelo Augusto , Meisinger Kirsten , Teixeira Liliane Reis
Published: January 2023

Introduction: Obesity is considered a growing public health problem by the Brazilian Ministry of Health and a global epidemic by the World Health Organization (WHO). In 2020, the Centers for Disease Control and Prevention (CDC) estimated the prevalence of adult obesity at 31.9% in the USA. The USA is one of the main destinations for Brazilian immigrants in search of better living conditions, and Massachusetts is one of the states with the highest presence of Brazilians. Changes in lifestyle and eating habits are often associated with increases in overweight and obesity in immigrants in the USA, especially Hispanics, an official classification that does not, however, include Brazilians. The aim of this study was to describe the temporal trend of overweight and obesity in Brazilian immigrants assisted by the Cambridge Health Alliance (CHA) healthcare network in Massachusetts. Methods: This was an ecological time series study of 128,206 records of Brazilians aged between 18 and 60 years based on hospital data from 2009 to 2020. Results: Mean age was 38.9 (SD = 10.6), and 61% of the sample were women. The prevalence of overweight and obesity was 38.4% and 25.4%, respectively. Obesity exhibited an increasing trend, while eutrophy and overweight decreased during the study period. Conclusion: As little is known about the health of Brazilian immigrants in the USA, this study contributes to the literature on the subject. The observed increasing trends agree with the worldwide increase in obesity and indicate the need for future research exploring individual factors associated with immigrant acculturation.
Dual-Task Upper Extremity Motor Performance Measured by Video Processing as Cognitive-Motor Markers for Older Adults
Authors: Wang Changhong , Zahiri Mohsen , Vaziri Ashkan , Najafi Bijan
Published: January 2023

Introduction: The use of dual-task model such as dual-task gait has been extensively studied to assess cognitive-motor performance among older adults. However, space restriction and safety factor limit its applications in remote assessment. To address the gap, we propose a video processing-based approach to remotely quantify cognitive-motor performance using a 20-s repetitive elbow flexion-extension test with dual-task condition, called video-based motoric-cognitive meter (MCM). Methods: Eighteen older participants (age: 78.6 ± 6.5 years) who were clinically diagnosed as having either mild cognitive impairment or dementia were included in this study. Participants were asked to perform 20-s repetitive elbow flexion-extension exercise with a memory exercise by counting backward from a two-digit number. During the test, all movements of the forearm were recorded by a video camera. As a comparator, a validated wrist-worn sensor was used, which allowed quantifying upper extremity kinematics. Results: The results showed a good agreement (r ≥ 0.530 and ICC2,1 ≥ 0.681) between the derived dual-task upper extremity motor performance from the proposed video-based MCM and a clinically validated sensor-based MCM. We also observed moderate correlations (r ≥ 0.496) between some measures of video-based MCM (flexion time, extension time, and flexion-extension time) and clinical cognitive scale (Mini-Mental State Examination [MMSE]). Additionally, some measures of dual-task upper extremity motor performance (speed, flexion time, extension time, and flexion-extension time) were associated with dual-task gait speed (r ≥ 0.557), which has been found to be correlated with cognitive impairment. Lastly, the selected dual-task motor performance metric (flexion time) was sensitive to predict MMSE scores in linear regression analyses with statistical significance (adjusted R2 = 0.306, p = 0.025). Conclusion: This study proposes a video processing-based approach to analyze dual-task upper extremity motor performance from a simple and convenient upper extremity function test. The results indicate concurrent validity of the proposed video-based MCM compared with the sensor-based MCM, and associations between dual-task upper extremity motor performance and clinically validated cognitive markers (MMSE scores and dual-task gait). Future studies are warranted to explore sensitivity of this solution to promote remote assessment of cognitive-motor performance among older adults in telehealth applications.
Caspase-3 Inhibition toward Perinatal Protection of the Developing Brain from Environmental Stress
Authors: Kaji Anna Arjun , Torii Masaaki , Ishii Seiji
Published: January 2023

Throughout our lives, we are exposed to a variety of hazards, such as environmental pollutants and chemical substances that affect our health, and viruses and bacteria that cause infectious diseases. These external factors that are undesirable to an organism are called environmental stress. During the perinatal period, when neural networks are drastically reorganized and refined, the tolerance of the developing brain to various environmental stresses is lower than in adulthood. Thus, exposure to environmental stress during this vulnerable period is strongly associated with cognitive and behavioral deficits in later life. Recent studies have uncovered various mechanisms underlying the adverse impacts of environmental stress during the perinatal period on brain development. In this mini-review, we will present the findings from these studies, focusing on caspase-mediated apoptotic and nonapoptotic effects of environmental stress, and discuss several compounds that mitigate these caspase-mediated effects as examples of potential therapeutic approaches.
Comparing individual and group-level simulated neurophysiological brain connectivity using the Jansen and Rit neural mass model
Authors: Kulik S. D. , Douw L. , van Dellen E. , Steenwijk M. D. , Geurts J. J. G. , Stam C. J. , Hillebrand A. , Schoonheim M. M. , Tewarie P.
Published: January 2023

Computational models are often used to assess how functional connectivity (FC) patterns emerge from neuronal population dynamics and anatomical brain connections. It remains unclear whether the commonly used group-averaged data can predict individual FC patterns. The Jansen and Rit neural mass model was employed, where masses were coupled using individual structural connectivity (SC). Simulated FC was correlated to individual magnetoencephalography-derived empirical FC. FC was estimated using phase-based (phase lag index (PLI), phase locking value (PLV)), and amplitude-based (amplitude envelope correlation (AEC)) metrics to analyze their goodness of fit for individual predictions. Individual FC predictions were compared against group-averaged FC predictions, and we tested whether SC of a different participant could equally well predict participants’ FC patterns. The AEC provided a better match between individually simulated and empirical FC than phase-based metrics. Correlations between simulated and empirical FC were higher using individual SC compared to group-averaged SC. Using SC from other participants resulted in similar correlations between simulated and empirical FC compared to using participants’ own SC. This work underlines the added value of FC simulations using individual instead of group-averaged SC for this particular computational model and could aid in a better understanding of mechanisms underlying individual functional network trajectories.
The Excluded Population: Indigenous Peoples’ Right to Health in Cameroon
Authors: Njieassam Esther Effundem
Published: January 2023

The right to health has gained international recognition. The Pygmies and Mbororo of Cameroon are yet to enjoy this right. The right to health is relatively related to and dependent upon the realization of other human rights as explicated in the International Bill of Rights as they form an integral part of the right to health. Despite some noticeable strides made by the government of Cameroon in ensuring that healthcare facilities are available and accessible within every five kilometres nationwide, these services are limited to urban cities, making it difficult for indigenous populations to access. The absence of a legal framework to safeguard the right to health for the population and indigenous peoples in particular, hinders their access to modern healthcare systems. It concludes that government must demonstrate a political will in ensuring equality in healthcare in the country to help remove indigenous peoples at the margin of social structures.
High-Performance Circulating Tumor DNA Liquid Biopsy Based on Graphitic Carbon Nitride Nanosheet for Monitoring Gastric Cancer-Related Gene Mutations
Authors: Pan Xiaoming , Xu Chaobo , Cheng Guoxiong , Chen Zhengwei , Liu Ming , Mei Yijun
Published: January 2023

Early diagnosis and timely monitoring of cancer progression are the most effective ways to improve the cure rate of cancer patients. And it is essential to create convenient, sensitive, accurate, as well as noninvasive or minimally invasive tests for better respecting patients’
wishes and optimizing diagnosis. The fluorescent biosensor discovered in our study on the basis of graphitic carbon nitride nanosheet (CNNS) could be used to detect the gastric cancer-associated circulating tumor DNA (ctDNA) in human blood by highly specific binding to fluorescein-labeled
single-stranded DNA detection probes. The ssDNA detection probe was adsorbed on the surface of CNNS through weak Π–Π stacking, thereby obtaining efficient fluorescence quenching. With the presence of the target DNA, the ssDNA probe showed weak affinity for CNNS and restored
fluorescence by base complementary pairing with target ssDNA through strong hydrogen bonds. The results show that the nanometer detection is a convenient, low-cost and high-efficiency technology, which is promising in biological detection and analysis.
Fenugreek Extract-Loaded Polycaprolacton/Cellulose Acetate Nanofibrous Wound Dressings for Transplantation of Unrestricted Somatic Stem Cells: An In Vitro and In Vivo Evaluation
Authors: Zhu Na , Meng Shuai , Li Jianchun , Liu Tianjun , Rohani Saeed
Published: January 2023

Complex pathophysiology of diabetic wounds causes a delayed wound healing response. Advanced wound dressing materials that deliver biochemical cues are of particular interest in wound healing research. Here, we developed a dual-function delivery vehicle for drug and cell delivery applications
to treat diabetic wounds. The delivery system was developed via electrospinning of polycaprolacton/cellulose acetate solution containing fenugreek extract. The produced delivery vehicle was characterized using microstructural studies, cell viability assay, cytoprotection assay, cell migration
assay, In Vitro anti-inflammatory assay, free radical scavenging assay, tensile strength studies, swelling studies, and protein adsorption test. Scaffolds were then seeded with 30000 unrestricted somatic stem cells and transplanted into the rat model of excisional diabetic wound. Wound
healing assay showed that the co-delivery of fenugreek extract and unrestricted somatic stem cells led to a substantial improvement in the healing activity of electrospun dressings, as evidenced by higher wound contraction, epithelial thickness, and collagen deposition in this group compared
with other experimental groups. Gene expression analysis showed that dual-function delivery system could increase the expression level of VEGF, b-FGF, and collagen type II genes. Furthermore, the tissue expression level of IL-1β and glutathione peroxidase genes was significantly
reduced in this group compared with other groups. This study shows that the developed system may be considered as a potential treatment modality for diabetic wounds in the clinic.
Optimized Green Synthesis and Anticancer Potential of Silver Nanoparticles Using Juniperus procera Extract Against Lung Cancer Cells
Authors: Alsubhi Nehad S. , Alharbi Njud S. , Felimban Afnan I.
Published: January 2023

Silver nanoparticles (AgNPs) have been considered promising candidates for medical practices in various fields. This study proposed an efficient, economical, uncomplicated, and reliable method to synthesize AgNPs utilizing leaf and fruit extracts of Juniperus procera (J. procera)
as capping, reducing, and stabilizing agents. The study includes optimizing the green synthesis conditions to produce stable AgNPs with high yields, acceptable particle size, and shape, hence, AgNPs may be used for different medical purposes through the improvement of their properties. Several
spectroscopic and other analyses performed characterization of the fabricated AgNPs, and the results show stable and spherical AgNPs between 14 and 18 nm in size. The study also evaluated the anticancer activities of the biosynthesized AgNPs using J. procera fruit and leaf extracts
against in vitro lung cancer A549 and H1975 cells. The results demonstrate the high toxicity of the biosynthesized AgNPs against in vitro lung cancer cells, supporting therapeutic and biomedical applications of AgNPs.
Electrocardiographic and Echocardiographic Features of Carnitine-Deficient Animal Model
Authors: Yin Kun , Zhang Kai , Zhao Qianhao , Wu Qiuping , Zheng Jingjing , Zhou Nan , Tang Shuangbo , Makielski Jonathan C. , Cheng Jianding
Published: January 2023

Primary systemic carnitine deficiency (CDSP) is a rare disease that can lead to sudden cardiac death (SCD). Meanwhile, cardiac manifestations had been widely reported in CDSP cases. Researches on phenotype and mechanism are needed imperatively to evaluate the influence of carnitine
deficiency on cardiovascular system. We induce an intraperitonealinjected carnitine deficiency mouse model and a transgenic mouse model created by CRISPR/Cas-mediated genome engineering to observe the ECG and echocardiography parameters to explore the cardiac pathophysiological features in
carnitine deficiency. In female drug-induced carnitine-deficient mice, the tendency of shortened QTc interval existed in experimental groups compared with the control group (P<0 05). Statistically significant differences in QTc interval existed in low-dose as well as high-dose groups
and control (P<0 05). The same rule appeared in heart rate (HR) and T wave duration (P<0 05). After 8 weeks of continuous injection, HR, left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) in low-dose group, HR as well as LVPWd in high-dose
group increased significantly compared with the control (all P<0 05). In male drug-induced carnitine deficient mice, the tendency of shortened QTc interval also existed in experimental groups compared with the control group (P<0 05). Statistically significant differences in QTc
interval existed in low-dose group and control (P<0 05). Compared with the control, PR interval declined significantly in high-dose group (P<0 05). After 8 weeks of continuous injection, no cardiac functional indexes in experimental groups altered significantly compared
with the control (all P>0 05) were found. In transgenic mice, free carnitine (C0) level statistically decreased (P<0 05) compared with the wild-type (WT) mice. There was no statistical difference between mice carried two single heterozygote (P>0 05). However, C0 level
between compound heterozygote and single heterozygote was statistically significant (P>0 05). Moreover, there were no significant differences recorded compared with WT in ECG and echocardiography (P>0 05). This study suggested that carnitine deficiency had impact on cardiac
function and structure in some situations. We summarized the ECG and echocardiography features of carnitine-deficient mice model and build the first transgenic animal model imitating the pathogenic genotype in human CDSP patients, which provide a foundation for further research on pathophysiological
and molecular mechanism.
Sulfur hexafluoride microbubbles combined with serology distinguish benign and malignant ovarian tumors
Authors: Chen Ying , Wang Haihua , He Yazhou , Liu Lu , Xu Lili
Published: January 2023

To explore the value of contrast-enhanced ultrasound with Sulfur hexafluoride microbubbles, serum carbohydrate antigen 125, carcinoembryonic antigen and human epididymis protein 4 joint inspection in the differential diagnosis of ovarian tumors. A total of 56 patients with ovarian tumors
were chosen as research materials from June 2018 to October 2021. Result show 24 patients of benign tumors and 32 patients of malignant tumors were confirmed by pathological diagnosis. The rise time and time to peak values of malignant tumors were lower than those of benign tumors (p<0.001).
However, peak intensity, Time intensity curve -Area under Curve and serum human epididymis protein 4, carcinoembryonic antigen, carbohydrate antigen 125 levels joint inspection in malignant tumors were higher than those in benign tumors (p < 0.001). Rise time, peak intensity and
time to peak in benign and malignant ovarian tumors were 0.895 (0.802–0.999, 95% CI), 0.852 (0.804–0.916, 95% CI), 0.907 (0.829–0.925, 95% CI), respectively. Area under Curve were 0.909 (0.846–1.012, 95% CI) and serum carbohydrate antigen 125 and carcinoembryonic antigen
and human epididymis protein 4 for diagnosis of benign and malignant ovarian tumors were 0.865 (0.838–0.991, 95% CI), 0.816 (0.702–0.930, 95% CI), 0.903 (0.850–1.007, 95% CI). Contrast-enhanced Ultrasound unite to serum carbohydrate antigen 125 and carcinoembryonic antigen
and human epididymis protein 4, the accuracy rate 92.86% (52/56) significantly higher than Contrast-enhanced Ultrasound or serum v diagnosis benign and malignant of ovarian tumor (p<0.01, 92.86% vs. 82.14%, p<0.001, 92.86% vs. 73.21%). Conclusion Contrast-enhanced Ultrasound,
carbohydrate antigen 125, carcinoembryonic antigen, human epididymis protein 4 joint inspection can improve the accuracy of early ovarian cancer.
The depth of anesthesia under sevoflurane can be monitored based on calling names language paradigm and Ag/AgCl electrooculogram electrode
Authors: Liu Jun , Wang Guozheng , Cao Zhen-gang , Hang Fan , Dong Kangli , Zhang Delin
Published: January 2023

In the depth of anesthesia monitoring, electrooculogram is usually treated as an artifact of EEG. However, the amplitude of the electrooculogram is much greater than that of electroencephalography. Its requirements for electrode materials and detection circuits are also far lower than
electroencephalography. In this prospective cohort study, we use a new language paradigm that elicited rhythmic ocular muscle activity to explore whether the electrooculogram can be used for monitoring the depth of anesthesia. Thirty-three patients inhaled sevoflurane via a laryngeal mask
for induction of anesthesia. According to the end-tidal sevoflurane concentration, patients were studied under three depth of sedation. Throughout all periods, the rhythmic calling of the patient’s own name script was sporadically played at a frequency of 0.5 Hz. We found that the electrooculogram
was synchronized to the language paradigm during induction with sevoflurane, and the Ag/AgCl electrode has a significantly higher signal-to-noise ratio and 0.5 hz spectral peak value than other electrode. With the increase in the sevoflurane concentration, the synchronizing ability gradually
weakened and eventually disappeared. Based on this evidence, we proposed a new method that can improve the performance of the anesthesia prediction monitoring model.
Mechanism of miR-155 carried with nanoparticles and dexmedetomidine in regulating oxidative stress and inflammation in rats with gonitis
Authors: Wang Wei , Peng Miao , Lu Lin
Published: January 2023

The aim of this study was to assess mechanism of miR-155 carried with nanoparticles and Dexmedetomidine in regulating oxidative stress and inflammation in rats with gonitis. Model of rats with gonitis was established and rats were treated by miR-155 nanoparticles and Dexmedetomidine
(Dex) or combined method. The rat weight growth rate (WGR), toe swelling, and arthritis index were then analyzed. Proliferative and apoptotic conditions were detected, while expression levels of IL-18 and IL-1β were detected with enzymelinked immunosorbent assay (ELISA) method.
The malondialdehyde (MDA) content and superoxide dismutase (SOD) activity were analyzed, and expression level of NF-κB was detected with Western Blot assay. The rats with WGR in the treated sets were improved, while toe swelling and arthritis index were reduced. Moreover, proliferation
was restrained and apoptosis was prompted. The MDA content was reduced while SOD activity was increased, and expression levels of IL-18, IL-1β, and NF-κB were reduced. The action in the combined set was more notable, while the NF-κB signal pathway and
secretion of inflammatory factors were restrained by the miR-155 nanoparticles and Dex. Finally, the oxidative stress was improved, while inflammation was restrained, and symptom of gonitis were improved.
Coupling of the Liquid Sampling–Atmospheric Pressure Glow Discharge to Orbitrap Mass Analyzers for Uranium Isotope Ratio Analysis: Evolution of the Methodology and Implications to the Field
Authors: Koppenaal David W. , Marcus R. Kenneth
Published: January 2023

Just over a decade ago, a truly outside-of-the-box approach to isotope ratio mass spectrometry (IRMS) was undertaken between research groups at Clemson University and the Pacific Northwest National Laboratory. The original motivation dealt with projections as to whether or not microplasmas could be developed into practical elemental ionization sources, perhaps for transportable analysis applications. In particular, the use of the liquid sampling–atmospheric pressure glow discharge (LS-APGD) was pursued. Its interfacing to an ultra-high resolution Orbitrap platform, proved not only facile, but opened up a wealth of potential applications. Here, we lay out a historical, tutorial description of the interfacing and the evolution of the methodology regarding IRMS of uranium. Practical challenges and opportunities are described, which hopefully provide guidance to further applications in high resolution IRMS. It is hoped that, while detailed and lengthy, the didactic nature of the presentation provides experimental insights and tips, and also serves as an homage to our very good friend, Professor Gary M. Hieftje, whose scientific inspiration and comradery have been immeasurably important in our own careers.
Examining Ensemble Requirements for Music Education Majors
Authors: Hill Stuart Chapman , Haning Marshall , Giotta Dennis P. , Nannen Briana , Prendergast Jocelyn Stevens , Spears Amy , Tracy Elizabeth , Wilson Jill
Published: January 2023

To better understand existing ensemble requirements for music education majors at U.S. institutions, we conducted a content analysis of ensemble requirements for 1,021 degree programs at 465 colleges and universities accredited by the National Association of Schools of Music (NASM). The mean number of ensemble credits required for each degree program was 7.25 ( SD = 2.89), and the mean number of semester enrollments required was 7.86 ( SD = 1.95). There were significant differences between degree types (e.g., instrumental-focused, choral-focused) in terms of total ensemble credits required and number and kind of subrequirements (e.g., chamber or small ensemble). A majority of programs did not contain specific subrequirements beyond traditional large ensembles, suggesting that many students may not undertake the varied complement of ensemble experiences called for in the NASM standards. By continuing to diversify ensemble offerings and encouraging or requiring students in all degree specializations to develop their musicianship through a variety of ensemble experiences, music programs may be able to make valuable ensemble experiences even more beneficial for undergraduate music education students.
Financial compensation for natural forest logging ban: Standard calculation based on willingness to accept
Authors: Liao Wenmei , Ye Danyang , Yuan Ruolan , Zhang Yaoqi , Deng Qian
Published: January 2023

To alleviate the deteriorating environment and protect biodiversity, China has implemented a natural forest protection system, demonstrating the importance of sustainable forest management for ecological conservation and socio-economic development, including the complete cessation of commercial logging of natural forests. Financial compensation is adopted to increase farmers’ enthusiasm within the commercial Logging Ban of Natural Forests framework. This study used the contingent valuation method and the Heckman two-stage model to explore farmers’ willingness to participate in the Logging Ban of Natural Forests and the willingness to accept by survey data on 486 farming households. 72% of farmers are willing to join the Logging Ban of Natural Forests. Their willingness to accept is 517.95 yuan/ha per year, higher than the current state subsidy standard (225 yuan/ha per year). The key factors influencing willingness to accept include the education and degree of fragmentation of woodland and village collective willingness to accept. The age of the rural household head, the fragmentation of the forest, and the evaluation of the Logging Ban of Natural Forests policies have inhibited the increase of farmers’ compensation. Farmers’ assessment of the Logging Ban of Natural Forests policy only impacts the medium level of compensation. The age and the degree of forest fragmentation would affect the higher compensation amount. The results from this study suggest more financial sources and increased compensation standards are needed. The government should also strengthen ecological awareness and adopt different compensation standards for other groups to achieve sustainable forestry.
Risky Business: Effects of Risk-Related Reviews and Priming Cues in Uncertain Times
Authors: Cain Lisa , Kim Eun Joo , Tanford Sarah
Published: January 2023

The risks inherent in booking travel destinations include natural disasters, economic conditions, diseases, terrorism, and war. In times of uncertainty, peoples’ beliefs, biases, and attitudes influence decisions between competing choices. This research examined how affective and behavioral priming influence travelers’ responses to valence and risk cues within online reviews. The risk avoidance principle of prospect theory, in conjunction with the asymmetry effect of positive and negative information, underpinned the studies. The results revealed that different primes influenced responses to review risk content as a function of valence. Behavioral priming increased the impact of positive risk content, whereas negative affective priming amplified the effect of negative risk content. This study builds on the extant body of knowledge by using video to prime emotions and establishing the viability of multiple concurrent primes. The research provides practical suggestions for navigating risk- and affect-related travel influences during times of uncertainty.
Bolsonaro, the Last Colonizer
Authors: Domingos Neto Manuel , Guerreiro Moreira Luis Gustavo
Published: January 2023

The traditional relationship between the Brazilian state and indigenous peoples is based on the state’s “protection.” Under the ultraconservative Bolsonaro government, the state has been taken over by elites with rural and extractive capital who plan on exploiting the Amazon rain forest at any cost and see indigenous peoples as an obstacle to their goal. The military also has a noteworthy position in this offensive, which strikes at the heart of what are considered human rights. The legislative and judiciary branches continue to confront this ambiguous policy, which is accompanied by laws, statutes, national agreements, and international conventions that lack clarity and precision. If Bolsonaro were to be reelected it might mean the extinction of surviving indigenous ethnicities.

A relação tradicional entre o Estado brasileiro e os povos originários é baseada na “tutela” do Estado. O governo ultraconservador de Bolsonaro reflete a captura do Estado pelas elites do capital agrário e extrativista que pretendem dispor da floresta amazônica a qualquer custo, considerando os povos originários como obstáculo à sua agenda. Os militares têm posição de destaque nesta ofensiva que afronta as noções elementares de direitos humanos. Ora, os poderes Legislativo e Judiciário lidam com essa política de maneira ambígua, acompanhando leis, estatutos e convenções nacionais e internacionais de forma pouco precisa e pouco clara. Se Bolsonaro for reeleito, isso poderá acelerar a extinção das etnias indígenas sobreviventes.
Not Always Helpful: Linking Intrateam Helping Types to Team Effectiveness From a Role Theory Perspective
Authors: Lee Sang-Hoon , Liu Yihao , Koopmann Jaclyn , Seo Jee Young , Zhou Le , Yu Yangyi
Published: January 2023

Existing research on intrateam helping has predominantly taken a positive view on its impact on teams, overlooking the potential negative consequences that helping may elicit. To account for divergent implications of intrateam helping, we differentiate two types of helping that can manifest during teamwork: team autonomous helping and team dependent helping. Integrating this dual-type view of helping with a role theory perspective on teamwork, we propose a theoretical model that delineates the relationships among team goal orientations, two types of intrateam helping, team role-based functions (i.e., team role overload, team role coordination, and team role breadth self-efficacy), and team effectiveness. To test our model, we conducted two multi-wave survey studies, including 110 student project teams (Study 1) and 80 manufacturing teams in a pharmaceutical company (Study 2). Overall, the results showed that team autonomous helping benefited team role-based functions and ultimately team effectiveness, whereas team dependent helping hindered them. We also found that team learning goal orientation drove the occurrence of team autonomous helping in both studies, while team performance goal orientation drove team dependent helping in Study 1. By distinguishing between autonomous and dependent types of intrateam helping, and examining their unique motivational roots and divergent implications for teams, this research advances the extant literature by providing a more balanced account of the nature of helping in teams.
Whose time is it? Rancière on taking time, unproductive doing and democratic emancipation
Authors: Räber Michael
Published: January 2023

This essay argues that an alternative conception of time to that underlying the ideology of productivism and growth is not only possible, but desirable. The creation of this time requires what I refer to as the practice of refusal via taking time: the self-determined arrangement of the nexus of time, action and utility that begins with the a-synchronous insertion of unproductive time into the synchronous horizontal time of productivism. The essay is divided into three sections. The first offers the reader a discussion of Jacques Rancière’s notion of time as a social and political medium that partitions and distributes actions and utility. The subsequent section of the essay elaborates in aesthetic terms an account of unproductive time that is indifferent to the time of productivism. In the final section, I discuss examples that show how taking time to do ‘nothing’ can elicit an emancipatory politics that seeks to liberate us from the hegemony of productivism. I conclude that political theory should attend to time as a political medium and to the possibilities of its occupation, and that picturing the taking of time in terms of stopping the force of productivism’s normalized horizontal time by entering the unproductive time of reverie and aesthetic experience, provides a promising perspective from which to apprehend a time for thriftless refusals, deliberate dis-identifications, and the forging of cooperation among people(s) and with nature.
Recent Extensions of Robert F. Lusch's “Big Picture” Thinking
Authors: Ingene Charles Arthur , Lusch Virginia Newell
Published: January 2023

This abstract highlights Bob Lusch's stature in the profession, followed by a summery of four papers that extend Service-Dominant Logic originally developed by Lusch and Vargo. Three of Bob Lusch's ca-authors highlight their very positive interactions with Lusch. The abstract concludes with a brief synopsis of the Eulogy delivered at Bob's Funeral.