bluuebunny/crossref_metadata_2025 huggingface dataset:
Deciphering the Complexity of FSHD: A Multimodal Approach as a Model for Rare Disorders
Authors: Megalizzi Domenica , Trastulli Giulia , Colantoni Luca , Proietti Piorgo Emma , Primiano Guido , Sancricca Cristina , Caltagirone Carlo , Cascella Raffaella , Strafella Claudia , Giardina Emiliano
Published: October 2024

Rare diseases are heterogeneous diseases characterized by various symptoms and signs. Due to the low prevalence of such conditions (less than 1 in 2000 people), medical expertise is limited, knowledge is poor and patients’ care provided by medical centers is inadequate. An accurate diagnosis is frequently challenging and ongoing research is also insufficient, thus complicating the understanding of the natural progression of the rarest disorders. This review aims at presenting the multimodal approach supported by the integration of multiple analyses and disciplines as a valuable solution to clarify complex genotype–phenotype correlations and promote an in-depth examination of rare disorders. Taking into account the literature from large-scale population studies and ongoing technological advancement, this review described some examples to show how a multi-skilled team can improve the complex diagnosis of rare diseases. In this regard, Facio-Scapulo-Humeral muscular Dystrophy (FSHD) represents a valuable example where a multimodal approach is essential for a more accurate and precise diagnosis, as well as for enhancing the management of patients and their families. Given their heterogeneity and complexity, rare diseases call for a distinctive multidisciplinary approach to enable diagnosis and clinical follow-up.
Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?
Authors: Mirarchi Alessandra , Albi Elisabetta , Arcuri Cataldo
Published: October 2024

Microglia signatures refer to distinct gene expression profiles or patterns of gene activity that are characteristic of microglia. Advances in gene expression profiling techniques, such as single-cell RNA sequencing, have allowed us to study microglia at a more detailed level and identify unique gene expression patterns that are associated, but not always, with different functional states of these cells. Microglial signatures depend on the developmental stage, brain region, and specific pathological conditions. By studying these signatures, it has been possible to gain insights into the underlying mechanisms of microglial activation and begin to develop targeted therapies to modulate microglia-mediated immune responses in the CNS. Historically, the first two signatures coincide with M1 pro-inflammatory and M2 anti-inflammatory phenotypes. The first one includes upregulation of genes such as CD86, TNF-α, IL-1β, and iNOS, while the second one may involve genes like CD206, Arg1, Chil3, and TGF-β. However, it has long been known that many and more specific phenotypes exist between M1 and M2, likely with corresponding signatures. Here, we discuss specific microglial signatures and their association, if any, with neurodegenerative pathologies and other brain disorders.
Stress-Responsive Gene Expression, Metabolic, Physiological, and Agronomic Responses by Consortium Nano-Silica with Trichoderma against Drought Stress in Bread Wheat
Authors: Aljeddani Ghalia S. , Hamouda Ragaa A. , Abdelsattar Amal M. , Heikal Yasmin M.
Published: October 2024

The exploitation of drought is a critical worldwide challenge that influences wheat growth and productivity. This study aimed to investigate a synergistic amendment strategy for drought using the single and combined application of plant growth-promoting microorganisms (PGPM) (Trichoderma harzianum) and biogenic silica nanoparticles (SiO2NPs) from rice husk ash (RHA) on Saudi Arabia’s Spring wheat Summit cultivar (Triticum aestivum L.) for 102 DAS (days after sowing). The significant improvement was due to the application of 600 ppm SiO2NPs and T. harzianum + 600 ppm SiO2NPs, which enhanced the physiological properties of chlorophyll a, carotenoids, total pigments, osmolytes, and antioxidant contents of drought-stressed wheat plants as adaptive strategies. The results suggest that the expression of the studied genes (TaP5CS1, TaZFP34, TaWRKY1, TaMPK3, TaLEA, and the wheat housekeeping gene TaActin) in wheat remarkably enhanced wheat tolerance to drought stress. We discovered that the genes and metabolites involved significantly contributed to defense responses, making them potential targets for assessing drought tolerance levels. The drought tolerance indices of wheat were revealed by the mean productivity (MP), stress sensitivity index (SSI), yield stability index (YSI), and stress tolerance index (STI). We employed four databases, such as BAR, InterPro, phytozome, and the KEGG pathway, to predict and decipher the putative domains in prior gene sequencing. As a result, we discovered that these genes may be involved in a range of important biological functions in specific tissues at different developmental stages, including response to drought stress, proline accumulation, plant growth and development, and defense response. In conclusion, the sole and/or dual T. harzianum application to the wheat cultivar improved drought tolerance strength. These findings could be insightful data for wheat production in Saudi Arabia under various water regimes.
Efficacy of a High-Protein Diet to Lower Glycemic Levels in Type 2 Diabetes Mellitus: A Systematic Review
Authors: Flores-Hernández María Nelly , Martínez-Coria Hilda , López-Valdés Héctor E. , Arteaga-Silva Marcela , Arrieta-Cruz Isabel , Gutiérrez-Juárez Roger
Published: October 2024

Diabetes is a metabolic disease with a high worldwide prevalence and an important factor in mortality and disability in the population. Complications can be reduced or prevented with lifestyle changes in physical activity, dietary habits, and smoking cessation. High-protein diets (HPDs, >30% or >1.0 g/Kg/day) decrease hyperglycemia in part due to their content of branched-chain amino acids (BCAAs), mainly leucine. Leucine (and other BCAAs) improve glucose metabolism by directly signaling in the medio-basal hypothalamus (MBH), increasing liver insulin sensitivity. To determine the effectiveness of an HPD to lower hyperglycemia, we analyzed the results of published clinical studies focusing on the levels of fasting plasma glucose and/or glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus (T2DM). We carried out a systematic search for clinical studies using HPDs. We searched five databases (Scopus, Web of Science, PubMed, Epistemonikos, and Cochrane), collecting 179 articles and finally selecting 8 articles to analyze their results. In conclusion, HPDs are an effective alternative to reduce hyperglycemia in patients with T2DM, especially so-called Paleolithic diets, due to their higher-quality protein from animal and vegetal sources and their exclusion of grains, dairy products, salt, refined fats, and added sugars.
High-Sensitivity Troponin: Finding a Meaningful Delta
Authors: Wright Catherine X. , Wright Donald S. , Hu Jiun-Ruey , Gallegos Cesia
Published: October 2024

High-sensitivity cardiac troponin (hs-cTn) assays have significantly refined the resolution of biomarker-level detection and have emerged as the gold standard cardiac biomarker in evaluating myocardial injury. Since its introduction, hs-cTn has been integrated into the Fourth Universal Definition of Myocardial Infarction and various European Society of Cardiology (ESC) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines for the evaluation and diagnosis of chest pain syndromes. However, despite its integral role in caring for patients with chest pain, there are still substantive gaps in our knowledge of the clinical interpretation of dynamic changes in hs-cTn values. Whether a relative or absolute hs-cTn delta should be used to detect acute myocardial injury remains debatable. There are also emerging considerations of possible sex and racial/ethnic differences in clinically significant troponin deltas. In the emergency department, there is debate about the optimal time frame to recheck hs-cTn after symptom onset for myocardial infarction rule-out and whether hs-cTn deltas should be integrated into clinical risk scores. In this review, we will provide an overview of the history of clinical utilization of cardiac biomarkers, the development of hs-cTn assays, and the ongoing search for a meaningful delta that can be clinically applicable.
Safe and Effective Augmentation Mastopexy with Tumescent Local Anesthesia: A Decade of Experience
Authors: Ziani Federico , Tettamanzi Matilde , Arrica Giovanni , Cuomo Roberto , Filigheddu Edoardo , Trignano Claudia , Liperi Corrado , Rubino Corrado , Trignano Emilio
Published: October 2024

Background: Tumescent local anesthesia (TLA) is widely used in esthetic surgery due to its ability to reduce complications, eliminate the need for general anesthesia, provide effective pain control, and shorten hospitalization times. Methods: This study evaluates the use of TLA in 80 patients who underwent augmentation mastopexy between 2010 and 2022. A tumescent solution containing 500 mg lidocaine, 672 mg sodium bicarbonate, and 1 mg epinephrine in 1000 mL of saline was infiltrated, with an average of 300 mL per breast. The surgical technique involved creating a subpectoral pocket for textured round implants (250–400 cc), followed by careful hemostasis. Results: No patients required conversion to general anesthesia, and there were no signs of toxicity or major complications. Minor complications included wound dehiscence (6.2%), hematoma (2.5%), and capsular contracture (2.5%). Pain management satisfaction at 3 months post-surgery was rated as “outstanding” by 12.5% of patients, “excellent” by 67.5%, and “good” by 20%. The longest follow-up was 6 years, with no implant ruptures except one (1.2%). Conclusions: While the study did not include a control group or statistical analysis, the findings suggest that TLA is a safe and effective alternative to general anesthesia for augmentation mastopexy, providing excellent pain control and a low rate of complications.
Understanding the Dry Eye Disease-Related Symptoms in South America: Prevalence and Associated Factors—A Systematic Review
Authors: Loaiza-Guevara Valentina , Salazar-Santoliva Camila , Villota-Arevalo Alvaro J. , Acosta-Villas Marjorie E. , Coral-Gaón Betty-Liliana , Afanador Jesús E. , Restrepo Natalia , Hernandez-Benitez Laurens L. , Hernández Wendy Rincón , Caceres-Delgado Laura C. , Izquierdo-Condoy Juan S.
Published: October 2024

Background/Objectives: Dry eye disease is a leading cause of ophthalmologic consultations worldwide and can significantly impact quality of life. While global prevalence rates vary widely, data specific to South America are limited. This systematic review aims to describe and analyze the prevalence and associated factors of dry eye disease-related symptoms in South American populations. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted using databases such as PubMed, Web of Science, Scopus, and LILACS. Primary studies in English and Spanish that examined the prevalence of dry eye disease-related symptoms in South American populations and its associated factors were included without date restrictions. Studies were screened and selected based on predefined inclusion and exclusion criteria, resulting in the final inclusion of 16 studies from six South American countries. Results: This review identified significant variability in the prevalence of dry eye disease-related symptoms in South American populations in the region, ranging from 4% to 77.5%, with a mean prevalence of 39.3%. Higher prevalence rates were observed among specific groups, such as university students (58.6%) and administrative workers (57.9%). Factors associated with dry eye disease-related symptoms in South American populations included female sex, older age, prolonged screen time, insufficient sleep, and medical conditions such as hypertension, connective tissue disorders, and the use of medications like antihypertensives and antidepressants. Conclusions: The prevalence of dry eye disease-related symptoms in South American populations is notably higher than global averages, highlighting regional challenges. This study emphasizes the need for standardized diagnostic tools and comprehensive epidemiological research across South America, particularly in underrepresented countries, to inform public health strategies tailored to the specific needs of these populations.
Effect of Difference in Serum Creatinine between Jaffe and Enzymatic Methods in Outpatient Kidney Transplant Recipients
Authors: Boss Kristina , Stolpe Susanne , Müller André , Friebus-Kardash Justa , Wagner Bernd , Wichert Marc , Assert Roland , Volbracht Lothar , Stang Andreas , Kowall Bernd , Kribben Andreas
Published: October 2024

Background: Deviations in serum creatinine (SCr), due to its determination using a Jaffe or an enzymatic method, have an effect on kidney disease detection and staging. It is not yet clear how large this effect is in kidney transplant recipients (KTRs). SCr measurement differences are of particular importance here to evaluate the graft function. Methods: The results of all parallel SCr measurements (Jaffe and enzymatic method) of adult outpatient KTRs in the same serum sample at the University Hospital Essen (Germany) between January 2020 and October 2023 were evaluated. A Bland–Altman plot with 95% limits of agreement (LoA) was used to assess the difference between the Jaffe and the enzymatic SCr (eSCr). For all patients, we used the CKD-EPI 2009 and EKFC formula, and for patients ≥ 70 years, we also used the BIS1 formula for the determination of eGFR. Results: A total of 12,081 parallel SCr measurements from 1243 KTRs were analyzed, where 61% were male and the median age was 53 years. On average, Jaffe SCr was 0.03 mg/dL higher than eSCr (LoA −0.16; 0.21 mg/dL). On average, the eGFR determined by Jaffe SCr was 1.9 mL/min/1.73 m2 lower than the eGFR determined by eSCr (LoA −9.5; 5.7 mL/min/1.73 m2). The comparison of eGFR between the two SCr methods revealed a different CKD stage in 1589 (13%) of all analyzed measurements, most frequently between G2/G3a (41%) and G3a/G3b (24%). When using the EKFC and BIS1 formulas, there were approximately the same number of measurements leading to a different CKD stage. Conclusions: In more than every tenth SCr determination in outpatient KTRs, the difference between the Jaffe and enzymatic methods had an influence on the assignment to a CKD stage. This effect was comparably pronounced for all eGFR formulas applied.
Research on Decoupling Duty Cycle Optimization Control Method of a Multiport Converter for Dual-Port Direct Drive Wave Power Generation System
Authors: Huang Lei , Wang Shixiang , Pan Baoyi , Liu Haitao , Zhang Jiyu , Wu Shiquan
Published: October 2024

Dual-port direct drive wave energy power generation systems (DP-DDWEPGS) have received widespread attention due to their smooth and zero-free output power, compared to single-port direct drive wave energy power generation systems (SP-DDWEPGS) which have the disadvantage of large out-put power fluctuations. To further enhance the performance of the DP-DDWEPGS, optimal power capture control is proposed to achieve maximum power point tracking. Meanwhile, a multiport converter is applied to the DP-DDWEPGS to solve the problem caused by an excessive number of switching devices in the overall system converter. The multiport converter fulfills all the functional requirements of the DP-DDWEPGS while reducing the number of switching devices. However, switch multiplexing of the multiport converter also introduces coupling relationships between each port and the wave force exhibits time-varying characteristics, necessitating advanced control methods with superior fast-tracking capability. Therefore, in this paper, a decoupling duty cycle optimization model predictive control for DP-DDWEPGS is proposed. Based on the characteristics of switching multiplexing, NSC finite control set model predictive control (FCS-MPC) decouples the current prediction and the cost function, reduces the number of candidate voltage vectors in each operation, and shortens the operation time by 70%. To address the issues of high ripple value and increased error due to decoupling in FCS-MPC, duty cycle optimization control is added, greatly reducing the fluctuations in electromagnetic force and power of the permanent magnet linear generator (PMLG). Based on the established simulation model, the feasibility and superiority of the multiport converter and decoupling duty cycle optimization model predictive current control method are verified.
Energy Maximisation and Power Management for a Wave-to-Wire Model of a Vibro-Impact Wave Energy Converter Array
Authors: Chen Shuai , Jin Siya , Guo Bingyong , Yang Kunde
Published: October 2024

This paper develops a wave-to-wire model of a vibro-impact wave energy converter array for stand-alone offshore applications. Nonlinear model predictive control is proposed for maximising the wave power capture of the array, and implemented by AC/DC converters and the space vector pulse width modulation technique. A hybrid energy storage system, consisting of batteries and supercapacitors, is placed parallel to the DC bus via buck-boost DC/DC converters to smooth the array power output, and a Lyapunov-based power management strategy is utilised to control the DC/DC converters for stabilising the DC bus voltage. Intensive numerical simulations are conducted; the results show that the proposed wave-to-wire model is capable to evaluate the performance of the vibro-impact wave energy converter array in various scenarios, and the proposed energy maximisation control and power management strategy can enhance wave power capture and stabilise the power output simultaneously.
Big Data Analysis of the Speed Performance of a 176k DWT Bulk Carrier in Real Operating Conditions
Authors: Cho Yurim , Lee Inwon
Published: October 2024

Assessment of ship performance under in-service conditions is challenging due to the complex effects of many environmental disturbances. ISO 15016 and ISO 19030 standards are commonly used to evaluate ship operating performance. However, ISO 15016 requires numerous variables, a complex calculation formula, and considerable time and cost, and ISO 19030 only evaluates the reduction of ship speed caused by wind and neglects the effect of waves. To improve both standards and achieve a more accurate ship performance assessment, this study proposes a new performance prediction model, the multi-input single-output (MISO) system, which assumes that each ship has specific frequency characteristics according to type and size. Based on this new model, in-service navigation data collected from a 176k DWT bulk carrier, which amount to 5.7 million data points, are analyzed to assess the speed performance of the vessel subject to environmental disturbances. The proposed model was validated by comparing its results with ISO 19030 and specifically assessing the speed–power curves and speed reduction measured in operational data with the influence of environmental disturbances removed.
The Potential Use of Targeted Proteomics and Metabolomics for the Identification and Monitoring of Diabetic Kidney Disease
Authors: Van Roy Nele , Speeckaert Marijn M.
Published: October 2024

Diabetic kidney disease (DKD) is a prevalent microvascular complication of diabetes mellitus and is associated with a significantly worse prognosis compared to diabetic patients without kidney involvement, other microvascular complications, or non-diabetic chronic kidney disease, due to its higher risk of cardiovascular events, faster progression to end-stage kidney disease, and increased mortality. In clinical practice, diagnosis is based on estimated glomerular filtration rate (eGFR) and albuminuria. However, given the limitations of these diagnostic markers, novel biomarkers must be identified. Omics is a new field of study involving the comprehensive analysis of various types of biological data at the molecular level. In different fields, they have shown promising results in (early) detection of diseases, personalized medicine, therapeutic monitoring, and understanding pathogenesis. DKD is primarily utilized in scientific research and has not yet been implemented in routine clinical practice. The aim of this review is to provide an overview of currently available data on targeted omics. After an extensive literature search, 25 different (panels of) omics were withheld and analyzed. Both serum/plasma and urine proteomics and metabolomics have been described with varying degrees of evidence. For all omics, there is still a relative paucity of data from large, prospective, longitudinal cohorts, presumably because of the heterogeneity of DKD and the lack of patient selection in studies, the complexity of omics technologies, and various practical and ethical considerations (e.g., limited accessibility, cost, and privacy concerns).
The Determinants and Information Effects of Earnings Announcement Date Variability
Authors: Byun Sanghyuk , Roland Kristin C. , Kang Dongchang
Published: October 2024

Prior research finds mixed evidence that firms strategically manage their earnings announcement timing to either highlight or obscure financial information. While most prior studies focus on the specific timing and the nature of individual earnings announcements, we instead focus on the variability of firms’ annual earnings announcement dates (hereafter referred to as EADs) over a span of time. Using archival data collected from I/B/E/S and Compustat, we find that firms with fewer resources, weaker internal monitoring systems, and greater financial uncertainty are much more likely to exhibit increased EAD variability. Furthermore, we provide substantial evidence that the capital market’s response to earnings is noticeably weaker when a firm’s EAD variability is higher. Additional in-depth analysis reveals that firms exhibiting higher EAD variability tend to report significantly lower future performance in both the short- and long-term horizons. Consequently, while managers might intentionally alter an earnings announcement date to exploit variations in investor attention, this comprehensive study provides significant evidence that they should also consider how the market perceives and interprets the overall EAD variability. This understanding is crucial to improve strategic financial communication and maintain investor trust.
From Bank Preparation to Clinical Use of Homologous Skin Allografts in Wound Healing: A Sustainable Approach
Authors: Amoroso Laura , Agueci Serena , Pianigiani Elisa , Ierardi Francesca , Calabrese Laura , Rubegni Pietro , Tognetti Linda
Published: October 2024

Given progressive population ageing and the increase in the number of patients with comorbidities, the management of chronic and/or hard-to-heal wounds (HHWs) nowadays represents a common problem in many clinical settings. In these cases, standard strategies may not be sufficient. Autologous grafting represent the gold standard for permanent wound closure, but is almost never realized when the skin loss is extensive/the patient is young. The grafting of homologous skin/dermal tissue procured from cadaver donors (i.e., allografting) represents the best alternative, especially when the dermal component is lost. This request supports the activities of skin bank establishments (including donor screening, skin procurement, processing, storage, and distribution) that are regulated by specific guidelines and need to continuously meet quality standard requirements. The aim of this work is to both give specific insights of all the procedures implied in allograft preparation as well as an overview of their practical application in the treatment of different HHWs. The particular characteristics of each skin/dermal allograft released by Siena Skin Bank (cryopreserved/glycerol-preserved skin/de-epidermized dermis, acellular lyophilized de-epidermized dermis/reticular dermis) are also discussed. The exemplificative series of HHWs managed in the Dermatology Department of Siena were classified according their etiology into post-traumatic, vascular (arterial/venous/mixed/lymphatic), inflammatory, surgical, and heat/chemical burns. Globally, the clinical advantages obtained include: acceleration of healing process, pain sparing, resistance to bacterial contamination, dermal regeneration (instead of scarring), and better aesthetic–functional outcome.
Manual Therapy vs. Surgery: Which Is Best for Carpal Tunnel Syndrome Relief?
Authors: Donati Danilo , Boccolari Paolo , Tedeschi Roberto
Published: October 2024

Background: Carpal Tunnel Syndrome (CTS) is a common condition characterized by compression of the median nerve, leading to pain, numbness, and hand dysfunction. Both manual therapy and surgical decompression are widely used interventions, but their comparative effectiveness remains uncertain. Methods: A systematic review and a meta-analysis were conducted to compare the short- and long-term efficacy of manual therapy versus surgery for CTS. Studies were selected based on randomized controlled trials (RCTs) that met the inclusion criteria, focusing on outcomes such as pain intensity, hand function, symptom severity, and quality of life. Data were extracted and analyzed by using standardized tools to assess treatment effects. Results: Five RCTs with a total of 533 participants were included. Manual therapy was more effective for short-term pain relief, with significant improvements at 1 and 3 months compared with surgery. However, at 6 to 12 months, surgical intervention provided greater improvements in hand function and symptom severity. Quality-of-life improvements were similar in both groups. Risk of bias was moderate to low across the studies, with limitations in blinding due to the nature of the interventions. Conclusions: Manual therapy offers effective short-term relief for CTS, making it a viable option for patients with mild to moderate symptoms. Surgery provides more durable, long-term outcomes, particularly for severe cases. The choice of treatment should be individualized, considering patient preferences and symptom severity.
SDIMMMER: A Proposed Clinical Approach to Optimize Cellular Physiology in Regenerative Medicine
Authors: Lana João Vitor , Lana José Fábio , Melo Gregory , Azzini Gabriel Ohana Marques , Santos Gabriel Silva , Mosaner Tomas , Jorge Daniel de Moraes Ferreira , da Fonseca Lucas Furtado , Kruel André , Costa Fábio Ramos , Jeyaraman Madhan , de Macedo Alex Pontes , Santos Napoliane , Pires Luyddy , Tambeli Claudia Herrera
Published: October 2024

SDIMMMER is an acronym intended for use in both clinical practice and medical research. It facilitates a comprehensive evaluation of a patient’s metabolic profile and serves as a mnemonic for the following key assessment areas: Sleep, Diet, Microbiome, Metabolism, Medications, Exams, and Rehabilitation. In the clinical setting, SDIMMMER’s primary objective is to monitor and manage the patient’s metabolic status, particularly targeting low-grade chronic systemic inflammation, a hallmark of metabolic syndrome (MS). This inflammatory condition is characterized by elevated levels of circulating inflammatory cytokines and increased macrophage infiltration in peripheral tissues. SDIMMMER aims to enhance the effectiveness of ortho biological treatments by elevating growth factor levels, thereby enhancing patient outcomes. Additionally, SDIMMMER emphasizes guiding patients toward positive lifestyle changes to improve overall quality of life and foster a healthier metabolism. SDIMMMER introduces a patient metabolic profile quantification tool comprising 7 domains, totaling 35 items. Additionally, an instructional guide is provided to facilitate the application process. Its versatility spans various clinical and research domains, showcasing its potential to positively influence multiple fields.
Bending Performance of Reinforced Concrete Beams with Rubber as Form of Fiber from Waste Tires
Authors: Ecemiş Ali Serdar , Madenci Emrah , Karalar Memduh , Fayed Sabry , Althaqafi Essam , Özkılıç Yasin Onuralp
Published: October 2024

An investigation was conducted to assess the efficacy of using waste rubber as a substitute for a portion of an aggregate to enhance concrete’s sustainability. For the purpose of accomplishing this objective, a total of 12 specimens were constructed and then subjected to a series of tests to investigate their bending behavior. The samples were constructed with the following dimensions: 1000 mm length and a 100 mm by 150 mm cross-sectional area. A few factors were selected, including the impacts of the longitudinal reinforcement ratio and the waste rubber ratio. Based on the volume of aggregates, rubber replacement rates of 0%, 5%, 10%, and 15% were investigated in this study. To assess the beam bending behavior, the stirrup width and spacing were kept constant at ∅6/10. The longitudinal reinforcement was composed of three diameters: ∅6 at the top (for all beams) and ∅8, ∅10, and ∅12 at the bottom. The experimental results demonstrated that the effects of varying amounts of waste rubber and tension reinforcement on the bending and cracking of reinforced concrete beams (RCBs) were varied. The findings indicate that the incorporation of waste rubber into concrete results in a reduction in both the load-carrying capacity and the level of deformation of the material. Additionally, it was shown that as the amount of waste rubber in the RCB increased, the energy absorption capacity and ultimate load decreased. There was a reduction in energy dissipation of 53.71%, 51.69%, and 40.55% for ∅8 when longitudinal reinforcement was applied at 5%, 10%, and 15% replacement, respectively. Additionally, there were reductions of 25.35%, 9.31%, and 58.15% for ∅10, and 38.69%, 57.79%, and 62.44% for ∅12, respectively.
Spectroscopic Properties of TmF3-Doped CaF2 Crystals
Authors: Schornig Carla , Stef Marius , Buse Gabriel , Poienar Maria , Veber Philippe , Vizman Daniel
Published: October 2024

In this study, we report the growth and comprehensive spectroscopic analysis of TmF3-doped CaF2 crystals, grown using the vertical Bridgman method. The optical absorption and photoluminescence properties of both trivalent (Tm3+) and divalent (Tm2+) thulium ions were investigated. Optical absorption spectra in the UV-VIS-NIR range reveal characteristic transitions of Tm3+ ions, as well as weaker absorption bands corresponding to Tm2+ ions. The Judd–Ofelt (JO) formalism was applied to determine the intensity parameters Ω2, Ω4, and Ω6, which were used to calculate radiative transition probabilities, branching ratios, and radiative lifetimes for the Tm3+ ions. The emission spectra showed concentration-dependent quenching effects, with significant emissions observed for the concentration of 0.1 mol% TmF3 under excitation at 260 nm and 353 nm for Tm3+ ions and at 305 nm for Tm2+ ions. A new UV emission associated with divalent Thulium is reported. The results indicate that higher TmF3 concentrations lead to increased non-radiative energy transfer, which reduces luminescence efficiency. These findings contribute to the understanding of the optical behavior of Tm-doped fluoride crystals, with implications for their application in laser technologies and radiation dosimetry.
Grain Structure Engineering in Screen-Printed Silver Flake-Based Inks for High-Temperature Printed Electronics Applications
Authors: Wadhwa Arjun , Saadati Mohammad , Benavides-Guerrero Jaime , Bolduc Martin , Cloutier Sylvain G.
Published: October 2024

We extensively studied serigraphic screen-printed commercial silver flake inks loaded with silicon inclusions in order to achieve pinning at the grain boundaries. Based on grain size measurements using electron backscattered diffraction (EBSD), commercial silver ink with silicon microparticle content of 5 wt.% shows significant grain growth retardation compared to pristine silver ink, which stabilizes electrical conductivity up to 700 °C via a Zener pinning mechanism. The modified silicon-loaded silver ink experiences a two-times increase in grain size when heated up to 700 °C, compared to a seven-times increase for pristine silver ink. In turn, this enables operation temperatures significantly higher than the conventional operational window of microparticle-based silver inks, which are usually limited to 400 °C. Using isothermal exposures of 10 min up to 4 h, this phenomenon is observed at temperatures ranging from 250 °C to 900 °C. The electrical conductivity stability, grain size evolution and oxide contents were studied up to 4 h. The activation energy of silver ink with silicon inclusions is 54% lower than for pristine silver ink due to the pining effect, which retards grain growth via the Zener mechanism. Most importantly, the electrical resistivity remains stable up to 700 °C, which is more than twice the operation limit for off-the-shelf screen-printable silver flake inks. Hence, we demonstrate that adding controlled amounts of silicon particles to silver inks for grain structure engineering can open new vistas of possibilities for screen-printed metallic inks.
Modeling the Geometry and Filter Composite of the Air Cleaner
Authors: Olszewska Pola Kalina , Pinkos Justyna , Borkowski Dominik , Jablonski Maciej
Published: October 2024

Air pollution is currently the most significant environmental factor posing a threat to the health and lives of European residents. It is a key cause of poor health, particularly respiratory and cardiovascular diseases. The primary aim of the study was to numerically determine the impact of the air purifier model’s geometry on the distribution of air within a room and to conduct experimental tests on the filtration efficiency and preliminary antibacterial activity of filtration composites. The scope of the work included designing an air purifier model in the form of a pendant lamp and performing computer simulations in Ansys software to identify the optimal shape. The experimental research focused on developing filtration composites consisting of nonwoven fabric with an active hydrosol layer, meltblown nonwovens and a carbon filter. The study results showed that the SMMS composite with 50% thyme and carbon nonwoven exhibited the highest filtration efficiency for both small and large particles.
Comparison of Curing Conditions on Physical Properties, Mechanical Strength Development, and Pore Structures of Phosphogypsum-Based Cold-Bonded Aggregates
Authors: Wang Guiming , Ye Zhiyi , Sun Tao , Mo Zhenlin , Wang Ziyan , Ouyang Gaoshang , He Juntu , Deng Yihua
Published: October 2024

This study compared the physical properties and mechanical strength development of PCBAs with water, sealed, standard, and open ambient air curing over 28 days to find a suitable curing method for the production of phosphogypsum-based cold-bonded aggregates. The types and relative amounts of hydration products, microstructural morphology and pore structure parameters were characterized utilizing XRD, TGA, FTIR, SEM and nitrogen adsorption methods. According to the results, water curing leads to rapid increases in single aggregate strength, reaching 5.26 MPa at 7 d. The standard curing condition improved the 28 d mechanical strength of the aggregates by 19.3% over others by promoting the generation of hydration products and the transformation of the C-S-H gel to a higher degree of polymerization and by optimizing the pore structure. Further, PCBAs achieved an excellent solidification of phosphorus impurities under all four curing conditions. This work provides significant guidance for selecting an optimized PCBA curing method for industrial production.
Study on Dynamic Strength Characteristics of Sand Solidified by Enzyme-Induced Calcium Carbonate Precipitation (EICP)
Authors: Li Gang , Hua Xueqing , Liu Jia , Zhang Yao , Li Yu
Published: October 2024

Saturated sand foundations are susceptible to liquefaction under dynamic loads. This can result in roadbed subsidence, flotation of underground structures, and other engineering failures. Compared with the traditional foundation reinforcement technology, enzyme-induced calcium carbonate precipitation technology (EICP) is a green environmental protection reinforcement technology. The EICP technology can use enzymes to induce calcium carbonate to cement soil particles and fill soil pores, thus effectively improving soil strength and inhibiting sand liquefaction damage. The study takes EICP-solidified standard sand as the research object and, through the dynamic triaxial test, analyzes the influence of different confining pressure (σ3) cementation times (CT), cyclic stress ratio (CSR), dry density (ρd), and vibration frequency (f) on dynamic strength characteristics. Then, a modified dynamic strength model of EICP-solidified standard sand was established. The results show that, under the same confining pressure, the required vibration number for failure decreases with the increase in dynamic strength, and the dynamic strength increases with the rise in dry density. At the same number of cyclic vibrations, the greater the confining pressure and cementation times, the greater the dynamic strength. When the cementation times are constant, the dynamic strength of EICP-solidified sand decreases with the increase in the vibration number. When cementation times are 6, the dynamic strength of the specimens with CSR of 0.35 is 25.9% and 32.4% higher than those with CSR of 0.25 and 0.30, respectively. The predicted results show that the model can predict the measured values well, which fully verifies the applicability of the model. The research results can provide a reference for liquefaction prevention in sand foundations.
Design, Analysis, and Optimization Testing of a Novel Modular Walking Device for Pipeline Robots
Authors: Shi Naiyu , Li He , Xu Ting , Hua Hongliang , Ye Junhong , Chen Zheng
Published: October 2024

This article investigates the limitations associated with traditional wheel-type pipeline walking devices, which are characterized by a single movement mode and an inability to navigate complex or irregular pipeline structures. A modular walking device (MWD) designed for pipeline robots was developed utilizing structural and mechanical analysis techniques. The reliability of the mechanical analysis was validated through single-factor dynamic testing. To analyze and optimize the factors influencing the maneuverability and obstacle-crossing capabilities of the MWD, a three-factor, three-level orthogonal testing method was utilized. The factors examined included the rotational speed of the walking wheel (RS), the pre-tightening force of the wheel brackets (PF), and the height of the annular obstacle (OH). The evaluation metrics used were the slip rate and passability. The results indicated that a parameter combination of RS at 70 rpm, PF at 30 N, and OH at 10 mm produced a slip rate of 11.6% ± 1.5%. During the obstacle traversal process, the remainder of the device maintained a safe distance from the obstacles, with only the walking wheel making contact. The verification testing also confirmed that the MWD is capable of executing three distinct modes of motion: rectilinear, rotational, and helical. The MWD designed and developed in this study can switch between multiple motion modes and successfully overcome obstacles within 15 mm, providing a new equipment for universities to enhance mechanized pipeline detection technology.
Study on Crashworthiness of Shrink Tube Anti-Creep Device
Authors: Zou Fan , Yao Shuguang , Zheng Xin , Xie Minhan , Yang Lei
Published: October 2024

Based on the requirements of the narrow installation space of a train end, compact energy-absorbing travel, and huge energy suck, a shrink tube anti-creep device was designed. The crashworthiness of different structures was studied by means of a material test, a trolley test, and numerical simulation. For every 1 mm increase in tube wall thickness, 1 mm increase in the axial length of the friction cone, and 0.01 increase in the friction coefficient, the mean crushing force (MCF) increased by 45.1 kN, 13.5 kN, and 30.5 kN, respectively. When the cone angle of the shrink tube increased from α = 5° to α = 25°, the increase in the MCF with different thicknesses was about 600%. The MCF was most affected by the cone angle, followed by the wall thickness, the friction coefficient, and the axial length of the friction cone. The change in the contact length of the friction cone of the shrink tube under different structural parameters was compared. The contact length decreased with the increase in tube wall thickness and increased with the increase in angle. The variation rule of MCF was obtained to provide a reference for the development of genealogical products.
State-of-the-Art Results with the Fashion-MNIST Dataset
Authors: Mukhamediev Ravil I.
Published: October 2024

In September 2024, the Fashion-MNIST dataset will be 7 years old. Proposed as a replacement for the well-known MNIST dataset, it continues to be used to evaluate machine learning model architectures. This paper describes new results achieved with the Fashion-MNIST dataset using classical machine learning models and a relatively simple convolutional network. We present the state-of-the-art results obtained using the CNN-3-128 convolutional network and data augmentation. The developed CNN-3-128 model containing three convolutional layers achieved an accuracy of 99.65% in the Fashion-MNIST test image set. In addition, this paper presents the results of computational experiments demonstrating the dependence between the number of adjustable parameters of the convolutional network and the maximum acceptable classification quality, which allows us to optimise the computational cost of model training.
Mathematical Limitations of Gravity Model in Constructing Regional Association Networks: A Case Study
Authors: Qin Qing , Li Lingxiao
Published: October 2024

This study evaluates the limitations of gravity models in constructing regional association networks, using China’s interprovincial economic connections as a case study. Comparison between a gravity-model-based simulated network and an actual network reveals significant topological differences. The gravity model overestimates the influence of larger, inward-oriented provinces and fails to accurately represent external connections. Attempts to refine the model with additional variables proved ineffective. Further theoretical analysis attributes these deficiencies to measurement bias from the model’s simplified binary perspective and information loss due to dimensional mismatch between pairwise predictions and complex network structures. These findings underscore the need for cautious application of gravity models and the development of more comprehensive analytical frameworks in regional network analysis.
Minimally Invasive Plate Osteosynthesis with Mini-Open Technique and Supraclavicular Nerve Preservation Reduces Postoperative Numbness in Acute Displaced Midshaft Clavicle Fracture
Authors: Liu Li-Tzu , Chen Jian-Chih , Yang Tsung-Cheng , Tseng Hsiang-Jui , Yen Shen-Ho , Lu Cheng-Chang , Chen Chung-Hwan , Chung Wan-Rong , Wang Ying-Chun
Published: October 2024

Background: Minimally invasive plate osteosynthesis (MIPO) for clavicular shaft fracture yields favorable functional outcomes and results in less surgery-related soft tissue injury than other techniques. Anterior chest and shoulder skin numbness, a common complication after open reduction and plate fixation, is related to injury to the supraclavicular nerves. We propose MIPO combined with a mini-open approach without fluoroscopy for nerve preservation to minimize the risk of postoperative numbness compared with traditional open plating without nerve preservation. Methods: A total of 59 patients were retrospectively identified, with a follow-up period of 6 months. Thirty-two patients underwent MIPO with mini-open and nerve preservation technique (MIPO group), and 27 patients underwent traditional open plating without nerve preservation (open group). Constant–Murley shoulder outcome score, operation time, wound length, skin numbness, and number of implant removals were compared between the groups. Results: The MIPO group had significantly lower rates of anterior chest and shoulder skin numbness than the open group (MIPO: 12.5% vs. open: 55.6%; p < 0.001). Operation time was significantly longer in the MIPO group than in the open group (MIPO: 109.38 ± 18.83 vs. open: 81.48 ± 18.85; p < 0.001). Wound length was significantly shorter in the MIPO group than in the open group (MIPO: 4.73 ± 0.79 vs. open: 9.76 ± 1.64; p < 0.001). Both groups had similarly excellent Constant–Murley shoulder scores. There were significantly fewer implant removals in the MIPO group than in the open group (MIPO: 6.3% vs. open: 25.9%; p = 0.036). Neither group experienced any infection, implant failure, or nonunion. Conclusions: Our technique combining MIPO with the mini-open approach and supraclavicular nerve preservation yields a lower incidence of skin numbness than traditional open plating without nerve preservation.
Surgical Treatment of Periarticular Distal Radius Fracture in Elderly: A Systematic Review
Authors: Testa Gianluca , Panvini Flora Maria Chiara , Vaccalluzzo Marco Simone , Cristaudo Andrea Giovanni , Sapienza Marco , Pavone Vito
Published: October 2024

Background/Objectives: The treatment of periarticular distal radius fractures remains challenging. Different surgical treatment options have been proposed as alternatives to conservative treatment. This systematic review aims to compare the functional outcomes, radiological outcomes, and complications among volar locking plates (VLPs), Kirschner-wire fixations, and external fixations (EFs) for distal radius fractures in patients aged 60 years and older. Methods: We conducted a comprehensive search of PubMed, Cochrane, and Science Direct databases assessing the effects of VLP, EF, and K-wire treatments for distal radius fractures in patients aged 60 years and over. The primary outcome was the evaluation of the range of motion (ROM) degrees after three surgical procedures, trying to assess the best treatment option. The secondary outcome included evaluation of the Disabilities of the Arm, Shoulder, and Hand (DASH) score, quick-DASH score, Patient-Rated Wrist Evaluation (PRWE) score, Visual Analog Scale (VAS) score, grip strength, radiographic assessment, and complications comparing VLPs, EFs and K-wires. Results: A total of 23 studies were included, comparing VLP, EF, and K-wire fixation. The overall population comprised 5618 patients, with 4690 females and 1015 males, of which 4468 patients were treated with VLP, 503 with EF, and 647 with K-wire. The most common complications among the VLP group were complex regional pain syndrome (7.5%) and carpal tunnel syndrome (6.8%); for the EF group, infections (9.8%) and carpal tunnel syndrome (6.8%); and for the K-wire group, carpal tunnel syndrome (7.5%) and infections (6.9%). Conclusions: VLP showed better clinical outcomes in the first few months after treatment. However, these differences decreased over time and became similar after one year. EF and K-wire fixations remain easier to manage during surgery.