bluuebunny/crossref_metadata_2025 huggingface dataset:
The New Seriality
Authors: Denson Shane
Published: December 2023

Since at least the nineteenth century seriality and serialization have been among the most important formal and narrative strategies for popular media cultures and their negotiations with the radical changes brought on by industrialization and new communication technologies. Nothing less is at stake in popular seriality than the material and spatiotemporal ordering of the phenomenal world, with far-reaching political consequences. However, in an age of computation, predictive algorithms, and “personalized” media, the parameters of serialization are massively transformed. And because media forms and social formations are tightly intertwined, this transformation—or the shift from an “old” to a “new” form of seriality—brings with it crucial changes and uncertainties with respect to subjective and collective existence going forward. Centrally at stake in the new seriality is a set of techniques and technologies that aim to predictively “typify” subjects and preformat them vis-à-vis normative and statistically correlated categories of gender and race, among others. This article lays the groundwork for thinking seriality as a sociotechnics of typification, the scope and power of which is greatly expanded by algorithmic media.
Forging an Anti-Bandung
Authors: Alsudairi Mohammed
Published: December 2023

During the course of the Cold War, Saudi Arabia cultivated close relations with the anti-communist states of East Asia. This development, this article argues, was driven by the shared positional marginality experienced by these actors vis-à-vis the Third World bloc. Unable to participate in the postcolonial possibilities unleashed in the mid-twentieth century, these states drew upon each other's visions of pan-Islamism and anti-communism to forge an “anti-Bandung.” As threats from the global Left intensified by the late 1960s, their reactionary solidarity transformed into an informal yet highly strategic alliance that lasted until the end of the global Cold War. This article calls for a broader conceptualization of inter-Asian and Afro-Asian solidarities that incorporates the narratives and activities of the non-Western Right and provides a new reading of Cold War Saudi Arabia that considers its complicated entanglements with Asia-centric anti-communist internationalism.
Titling in the Ruins
Authors: Kohlbry Paul
Published: December 2023

Palestinian Authority (PA) land titling began in 2005 as a means of creating property and sovereignty. Titling projects are extending government control over Palestinians, but they cannot secure their lands from Israeli state and private power. This article is an ethnography of Palestinian land titling, focusing on the specific problems that fraudulent land transfers to Israeli settlers create for such property-making efforts. It argues that for Palestinian administrators and surveyors, the certainty of Israeli colonization reduces progress to a challenge of speed and gives rise to short-term fixes that defer insoluble legal and political problems. The result is a form of nonsovereign property that encourages land markets now and offers the possibility of securing land rights later. The disjuncture between the future that land titling promises and the present it creates is entrenching private ownership in the West Bank and, as land speculation threatens to erode Palestinian control over territory, inciting debate about its limits. Land titling is creating a new political temporality in the ruins of state-building, one that illuminates how legacies of colonial law and contemporary practices of land speculation shape loss, hope, and contestation in Palestine and across the global South.
Another Third Worldism?
Authors: Bohdan Siarhei
Published: December 2023

This article investigates Iranian–North Korean cooperation after the 1979 revolution in Iran as a case of sustained efforts effectively aimed at implementing Third Worldist ideas. Both Iranian revolutionaries and North Korean Communist officials referred to Third Worldism, although they held different views of it. Their alliance, however, did not rest on ideology alone: by analyzing respective links, the article shows how substate actors following their pragmatic interests have succeeded in bringing about a relatively stable alliance that was rationalized through Third Worldist discourse. In Iran, this relationship was driven by the radical factions of the Khomeinist regime, mostly the so-called Islamic Left. These factions, who controlled some government-affiliated organizations and agencies (e.g., the Revolutionary Guards), needed these foreign links to get the resources necessary to survive and prevail politically. The study is largely based on Iranian sources of the time and memoirs by Iranian officials and activists.
Arwa Salih’s Gendered Critique
Authors: Ryan Brady Patrick
Published: December 2023

This article seeks to clarify the stakes of Arwa Salih’s critical methodology by reading her project—specifically, her development of Milan Kundera’s notion of kitsch, her analytic use of gender, and her formal and political concern with legacy and inheritance—alongside the literary history of iltizam. The article contends that Salih’s critical method and search for ethical knowledge frame iltizam as a form of militant kitsch that prized dogma and readymade answers over ethical and political curiosity. By reading Salih’s historical-political critique in terms of gendered literary symbolism and aesthetics, the article attempts to make clear the resonance of her analytic method in the field of modern Arabic literature—especially Egyptian literature—and to point out how literature and critique are implicated in the social and political changes that forged and solidified Egypt’s neoliberal era.
Abjection of Mother(land)
Authors: Gholami Zhila
Published: December 2023

This article presents a psychoanalytic reading of The Age of Orphans, the first installment of a trilogy by the Kurdish Iranian American novelist Laleh Khadivi. Drawing on Julia Kristeva’s theory of abjection and using close reading, this study explores different forms of abjection in the novel, both thematically and textually. By doing so, the article attempts to uncover the meanings of the novel’s fictional world, as well as its historical, political, and cultural context. Finally, this study, relying on Kristeva’s theory of intertextuality, reveals how the writings of Khadivi, a second-generation immigrant geographically and generationally distant from her Kurdish roots, contribute to Kurdish literature and literary expressions.
State-Led Antigender Politics, Islamism, and the University
Authors: Özbay Cenk , Ipekci Ilkan Can
Published: December 2023

Gender studies and its professors are attacked and oppressed by patriarchal, masculinist, antifeminist, and anti-LGBTI discourses and institutional practices. This trend is not limited to white- and/or Christian-majority countries, as the literature has documented thus far. Antigender campaigns can easily infiltrate Middle Eastern and/or Muslim-majority contexts in which feminists and queers have long struggled to transform societies, cultures, and states. In Turkey a state-led antigender movement has been unfolding, with burdensome outcomes for women and sexual minorities as well as activists and faculty members. The most recent step taken in the state-led antigender turn was Turkey’s withdrawal from the Council of Europe’s Istanbul Convention Action by a precipitous presidential decree. Drawing on thirty-three interviews with gender studies scholars, this article documents their ambivalent and perturbing connection with the state. The recent antigender atmosphere may make them feel downtrodden, silenced, and vulnerable in personal and professional domains, while it rejuvenates their resilience, renders their ongoing feminist/queer struggles meaningful and passionate, and cultivates an air of hope and optimism. To fight ostracism by public institutions and to attain their academic rights, the respondents use their empowering feelings, hope, and commitment against patriarchal and homophobic state forces.
Propagation and Insurance in Village Networks
Authors: Kinnan Cynthia , Samphantharak Krislert , Townsend Robert , Vera-Cossio Diego
Published: December 2023

Firms in developing countries are embedded in supply chains and labor networks. These linkages may propagate or attenuate shocks. Using panel data from Thai villages, we document three facts: as households facing idiosyncratic shocks adjust their production, these shocks propagate to other households on both the production and consumption sides; propagation is greater via labor than supply chain links; and shocks in denser networks and to more central households propagate more, while access to formal or informal insurance reduces propagation. Social benefits from expanding safety nets may be higher than private benefits. (JEL D13, D22, G22, I10, L14, L26, O10)
Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study
Authors: Li Huihui , Lin Dinghua , Lin Hongxin , Liu Min , Lu Guangqian
Published: December 2023

Objective: To explore the efficacy of Danshen injection combined with calcitriol and calcium/Vitamin-D in the treatment of osteoporotic fractures.

Methods: This was a case–control study. We retrospectively reviewed clinical data of 91 patients with osteoporotic fractures who received treatment in Rui’an People’s Hospital from February 2021 to July 2022. The data were divided into a control group with 44 records of patients who received treatment with calcitriol and calcium/Vitamin-D, and a study group with 47 patients who received Danshen injection combined with calcitriol and calcium/Vitamin-D. The control group individuals were coordinated with the patients in terms of their age and gender. Treatment effects, inflammatory response levels, and bone metabolic status levels were comparable between the two groups before and after the treatment.

Results: The total efficacy of the treatment in the study group was better than that in the control group (P<0.05). After the treatment, levels of serum inflammatory factors in both groups decreased compared to those before the treatment, and the study group displayed lower levels than the control group (P<0.05). After the treatment, the bone metabolism status of both groups improved, and the improvement effect of the study group was better (P<0.05). The incidences of adverse reactions were similar in both groups (P>0.05).

Conclusions: Danshen injection combined with calcitriol and calcium/Vitamin-D for the treatment of osteoporotic fractures can effectively reduce inflammation, regulate bone metabolism, and improve fracture treatment efficacy with a favorable safety profile.

doi: https://doi.org/10.12669/pjms.40.3.8513

How to cite this: Li H, Lin D, Lin H, Liu M, Lu G. Efficacy of Danshen injection combined with Calcitriol and Calcium/Vitamin-D for the treatment of osteoporotic fractures: A retrospective case-control study. Pak J Med Sci. 2024;40(3):291-296.  doi: https://doi.org/10.12669/pjms.40.3.8513

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Towards an extensive set of criteria for safety and cyber-security evaluation of cyber-physical systems
Authors: Smrčka Aleš , Sangchoolie Behrooz , Mingozzi Emanuele , de la Vara Jose Luis , Farrell Marie , Barbosa Raul , Baglum Cem , Yayan Ugur , Ergun Salih , Kanak Alper
Published: December 2023

Verification and validation (V&V) are complex processes combining different approaches and incorporating many different methods including many activities. System engineers regularly face the question if their V&V activities lead to better products, and having appropriate criteria at hand for evaluation of safety and cybersecurity of the systems would help to answer such a question. Additionally, when there is a demand to improve the quality of an already managed V&V process, there is a struggle over what criteria to use in order to measure the improvement. This paper presents an extensive set of criteria suitable for safety and cybersecurity evaluation of cyberphysical systems. The evaluation criteria are agreed upon by 60 researchers from 32 academic and industrial organizations jointly working in a large-scale European research project on 13 real-world use cases from the domains of automotive, railway, aerospace, agriculture, healthcare, and industrial robotics.
School and community driven dengue vector control and monitoring in Myanmar: Study protocol for a cluster randomized controlled trial
Authors: Overgaard Hans J. , Linn Nay Yi Yi , Kyaw Aye Mon Mon , Braack Leo , Win Tin Myo , Bastien Sheri , Vande Velde Fiona , Echaubard Pierre , Zaw Win , Mukaka Mavuto , Maude Richard
Published: December 2023

Background Dengue is the most common and widespread mosquito-borne arboviral disease globally estimated to cause >390 million infections and >20,000 deaths annually. There are no effective preventive drugs and the newly introduced vaccines are not yet available. Control of dengue transmission still relies primarily on mosquito vector control. Although most vector control methods currently used by national dengue control programs may temporarily reduce mosquito populations, there is little evidence that they affect transmission. There is an urgent need for innovative, participatory, effective, and locally adapted approaches for sustainable vector control and monitoring in which students can be particularly relevant contributors and to demonstrate a clear link between vector reduction and dengue transmission reduction, using tools that are inexpensive and easy to use by local communities in a sustainable manner. Methods Here we describe a cluster randomized controlled trial to be conducted in 46 school catchment areas in two townships in Yangon, Myanmar. The outcome measures are dengue cases confirmed by rapid diagnostic test in the townships, dengue incidence in schools, entomological indices, knowledge, attitudes and practice, behavior, and engagement. Conclusions The trial involves middle school students that positions them to become actors in dengue knowledge transfer to their communities and take a leadership role in the delivery of vector control interventions and monitoring methods. Following this rationale, we believe that students can become change agents of decentralized vector surveillance and sustainable disease control in line with recent new paradigms in integrated and participatory vector surveillance and control. This provides an opportunity to operationalize transdisciplinary research towards sustainable health development. Due to the COVID-19 pandemic and political instability in Myanmar the project has been terminated by the donor, but the protocol will be helpful for potential future implementation of the project in Myanmar and/or elsewhere. Registration: This trial was registered in the ISRCTN Registry on 31 May 2022 (https://doi.org/10.1186/ISRCTN78254298).
Polarization distribution of transverse ULF waves according to Van Allen Probe A data: whether toroidal and poloidal waves exist separately in the magnetosphere?
Authors: Yakimchuk Artur , Rubtsov Aleksandr , Klimushkin Dmitri
Published: December 2023

Ultralow-frequency (ULF) waves play an important role in energy transfer within Earth's magnetosphere due to intensive interaction with the surrounding plasma. Previous works have assumed that these waves are strictly divided by polarization into toroidal, when the magnetic field oscillates in the azimuthal direction, and poloidal, when it oscillates in the radial direction. The former are azimuthally large-scale and are excited by external sources, whereas the latter are small-scale and are generated by internal plasma instabilities. Observations show, however, that waves of mixed polarization often occur, and the nature of this mixing has not been explained. In this paper, we carry out a statistical study and show that the polarization of transverse waves has a normal distribution, and the maximum corresponds to oscillations of the toroidal and poloidal components with the same amplitude. At the same time, the spatial distributions of toroidal and poloidal waves are clearly different, but only lead to a small shift in the position of the distribution maximum. This result suggests that in order to compare the theory with ULF wave observations it is necessary to take into account the processes of polarization change, which can affect wave-particle interactions in the magnetosphere.
Isolated substorms according to magnetic measurements at Tixie during minimum solar activity
Authors: Baishev Dmitry , Makarov Georgy
Published: December 2023

A catalog of isolated substorms in 2016–2020 has been compiled from data on the H component of the geomagnetic field, obtained at Tixie. From the catalog data, it has been found that during this period changes in the number of substorms and the number of sunspots are well approximated by quadratic functions with minima at the end of 2017 and in the middle of 2019 respectively; during the year, disturbances more often occurred during solstice; within 24 hours, substorms more often occurred at local midnight. The intensity and duration of substorm disturbances, the duration of their expansion phase do not show a noticeable dependence on the time of occurrence; however, from average values of these parameters in hourly ranges, it has been found that the intensity takes lower values around 0–3 MLT; in the midnight sector, the duration of disturbances and the duration of their expansion phase are shorter than those in the dawn sector. Compared to the data from mid-latitude stations [Chu et al., 2015], the average duration of substorms and the duration of their expansion phase are longer.
Ionospheric longitudinal variability in the Northern Hemisphere during magnetic storms in March 2012 from ionosonde and GPS/GLONASS data
Authors: Chernigovskaya Marina , Yasyukevich Anna , Khabituev Denis
Published: December 2023

A comprehensive study of spatio-temporal variations of geomagnetic, ionospheric, and atmospheric parameters in the middle and high latitudes of the Northern Hemisphere during a series of magnetic storms in March 2012 has been expanded by including vertical total electronic content (TEC) data from measurements at the chains of dual-frequency phase receivers GPS/GLONASS in the analysis. The features of longitudinal variations in ionosphere ionization over mid-latitude Eurasia, found earlier from vertical sounding data, are confirmed by vertical TEC data. We emphasize the complex physics of the long magnetically disturbed period in March 2012 with switching between positive and negative effects of an ionospheric storm during the same magnetic storm phases for spaced mid-latitude regions of the Eastern Hemisphere. Such changes in the ionospheric storm effects might have been caused by the superposition of competing processes in the mid-latitude region of the Eastern Hemisphere due to variations in the thermospheric composition, thermospheric winds, and large-scale electric fields affecting ionospheric ionization. We have observed significant differences in the nature of the ionospheric ionization reaction between the Eastern and Western hemispheres to the prolonged geomagnetic disturbance in March 2012. According to TEC data, there was an effect of reduced ionization of the ionosphere at longitudes of the Western Hemisphere, unlike the Eastern one. The effect of a negative ionospheric storm was caused by the formation of vast areas of atmospheric gas with a reduced density ratio [O]/[N2] over the mid-latitude region of the Western Hemisphere in the zone of maximum penetration of geomagnetic disturbances from high latitudes to middle latitudes. According to the INTERMAGNET magnetometer chain data for the analyzed period of magnetic storms on March 7–20, 2012, at midlatitudes of the Northern Hemisphere the maximum geomagnetic field variations were observed in the Western Hemisphere.
Competence of project management professionals according to type of project: a systematic literature review
Authors: Rosamilha Nelson Jose , Silva Luciano Ferreira da , Penha Renato
Published: December 2023

Globalization and economic volatility changed the dynamics of production chains, which required new organizational arrangements from companies, leading them to projectization. Additionally, project professionals are managing increasingly complex projects, which demand an extensive and specific set of competences. In this context, this paper aims to identify the competences of project professionals by project type. A systematic literature review was carried out using the Scopus and Web of Sciences academic databases. The research corpus consisted of 209 articles published between 1989 and 2022. As a result, this research identified 173 competences distributed in 14 different project types; some competences have a greater significance for a given project type. As a contribution, when dealing specifically with projects and competences, project professionals, companies, and educational institutions can learn about the fundamental competences by type of project, improve the processes of selection and diagnosis of the professional, adapt educational programs, or even establish plans for project professionals career.
Proximity and Knowledge Spillovers: Evidence from the Introduction of New Airline Routes
Authors: Bai John (Jianqiu) , Jin Wang , Zhou Sifan
Published: December 2023

This paper examines the causal relationship between proximity and knowledge diffusion by estimating the elasticity of core-based statistical area (CBSA) pair-level citations to variations in travel time induced by the introduction of new flight routes. The findings reveal that decreasing travel time between U.S. cities by 20% increases knowledge flow by 0.5%, which corresponds to an increase of over 15,000 citations at the aggregate level. Rather than boosting within-firm knowledge transfer, travel time reduction leads to a rise in knowledge spillovers primarily across firm boundaries, particularly among those that form joint ventures, have block holdings in each other, or form supply chain relationships. These effects are stronger among city pairs located farther away from each other, with higher absorptive capacity, in complex technology classes, and for newly developed technologies. Additional mechanism tests suggest that the most likely channel through which travel time reduction impacts knowledge spillover is by influencing the transfer of tacit knowledge via facilitating cross-CBSA inventor flow and information acquisition.

This paper was accepted by Tomasz Piskorski, finance.

Funding: S. Zhou receives support from the National Natural Science Foundation of China [Grant 71804155] and China Fundamental Research Funds for the Central Universities [Grant 20720181047].

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.01717 .
The state of education in the Kharkiv region during the Second World War
Authors:   H. S. Skovoroda Kharkiv National Pedagogical University, Kostak Kateryna
Published: December 2023

During the Second World War, Ukraine was one of the 40 countries in the world, on the territory of which full-scale military operations were conducted, and the entire population of Kharkiv oblast, along with other regions, felt the full range of consequences of the darkness of war. The article examines the state of children's education in the Kharkiv region (1941–1943). The materials of the article reflect the tragic fates of the children with typical development and the children with psychophysical disorders, the participation of educational institutions and the level of ensuring the educational process. The publication describes the sequence and priority of evacuation of the population by the temporary authorities. It was found that everything of strategic value that was not taken to safer regions of the country and was destroyed (could reach the enemy). People during the occupation, which did not have the opportunity to evacuate, remained in inhumane conditions, widespread hunger reigned, and people died en masse. Regarding the education during the German occupation in Kharkiv, it is known that there were 20 public schools in the city. The «Prosvita» organization, consisting of pro-Ukrainian intelligents was of great importance for the cultural and educational life of Kharkiv oblast. The «Prosvita» set as its goal the revival of Ukrainian national ideas. The members of the organization were opponents of the Bolshevik regime, some were political prisoners and hoped that with the arrival of representatives of Germany on the territory of Ukraine, a better world would come that would not oppress the development of pro-Ukrainian ideas. Much attention is paid in the article to the analysis of the difficult fate of children with developmental disorders and the institutions in which they were brought up. There is also an overview of the five children's institutions that remained in the city: the V. H. Korolenko boarding school for blind children, the orphanage in Sokolnyky, orphanages No. 1, 2 and 7.
Semipositivity with respect to the Lorentz cone
Authors: Hisabia Aritra Narayan , Saha Manideepa
Published: December 2023

Lorentz cone in the Euclidean space $\mathbb{R}^{n}$ is defined as $\mathcal{L}^n_+:=\{x\in \mathbb{R}^n:x_n\geq 0,\sum\limits_{i=1}^{n-1}x_{i}^2\leq x_n^2\}$. The paper aims to study semipositivity of matrices with respect to $\mathcal{L}^n_+$. A $n\times n$ real matrix $A$ is $\mathcal{L}^n_+$-semipositive if there exists $x\in \mathcal{L}^n_+$ such that $Ax\in \mathop{\rm int} (\mathcal{L}^n_+)$ (the topological interior of $\mathcal{L}^n_+$). $\mathcal{L}^n_+$-positive matrices ($A(\mathcal{L}^n_+\setminus\{0\})\subseteq \mathcal{L}^n_+$) and minimally $\mathcal{L}^n_+$-semipositive matrices ($A^{-1}(\mathcal{L}^n_+)\subseteq \mathcal{L}^n_+$) are two important subclasses of $\mathcal{L}^n_+$-semipositive matrices. In this paper, we establish the existence of bases for the real vector space of $n\times n$ matrices, consisting of $\mathcal{L}^n_+$-positive matrices and of minimally $\mathcal{L}^n_+$-semipositive matrices. Sufficient conditions are determined for $\mathcal{L}^{n}_+$-semipositivity, in terms of the length of rows(columns) of the matrices. Furthermore, we discuss properties of $\mathcal{L}^n_+$-semipositive matrices involving product of matrices. At last, $\mathcal{L}^2_+$-semipositive matrices are described via entries of the matrices and equivalent $\mathcal{L}^n_+$-semipositive matrices are studied.
Synthesis, Structures and Antimicrobial Activities of Novel Schiff Base Ligand and Its Metal Complexes
Authors: Adhao Sopan Tejrao , Wagh Rahul Ramchandra
Published: December 2023

A novel ligand (E)-7-hydroxy-4-methyl-8-(1-(naphthalen-1-ylimino) ethyl)-2H-chromen-2-one [HOMNIEC] was synthesized by condensation of 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one and Naphthalen-1-amine by the reported method. The metal complexes with this ligand were synthesized by using a common new method. FTIR, 1H NMR, Mass Spectrometry and TGA techniques were used to confirm their structures. The FTIR spectral data indicate that the ligand was coordinated with the metal ions through the phenolic oxygen on coumarin moiety and nitrogen of azomethine. The ligand and complexes were examined for in vitro antimicrobial activities using broth microdilution method in DMSO medium against Escherichia Coli (MTCC 443) and Pseudomonas Aeruginosa (MTCC 1688) a gram-negative bacterial strain, Staphylococcus Aureus (MTCC 96) and Streptococcus Pyogenes (MTCC 442) a gram-positive bacterial strain, and Candida Albicans (MTCC 227), Aspergillus Clavatus (MTCC 1323) and Aspergillus Niger (MTCC 280) fungal strains. The metal complexes were found to have enhanced antimicrobial activities compare to the Schiff base [HOMNIEC] ligand. Especially, the antifungal activity of Cu(II) and Zn(II) ions complexes was found to be twofold more than the standard drug griseofulvin against C. Albicans.
Design, In Silico Studies, and Synthesis of Some Azole Derivatives as Antimicrobial Agents
Authors: Zaidi Syeda Huma Haider , Mohd Abida Ash , Imran Mohd , Alshammari Menwah Khalifah , Alfrah Khattab Fahed
Published: December 2023

This work relates to the discovery of safer and more potent triazole-pyridazinone hybrid (TP) compounds as an inhibitor of sterol 14α-demethylase (SDM). The chemical structures of thirty-three TPs (TP1 to TP33) were designed. The docking scores (DS) of TPs were determined by molecular docking software utilizing three different proteins of SDM (PDB IDs: 3LD6, 5FSA, and 5TZ1). The ProTox II web server predicted TPs' oral LD50 and toxicity class (TC), whereas the Swiss-ADME database anticipated their pharmacokinetic parameters. Based on the in silico study data, four TPs (TP18, TP22, TP27, and TP33) were synthesized and evaluated for their in vitro antifungal activity against seven fungi. The DS (kcal/mol) of TP18 (3LD6 = -8.27; 5FSA = -9.07; 5TZ1 = -9.42), TP22 (3LD6 = -8.23; 5FSA = -8.93; 5TZ1 = -9.57), TP27 (3LD6 = -8.31; 5FSA = -9.12; 5TZ1 = -9.38), and TP33 (3LD6 = -8.19; 5FSA = -8.98; 5TZ1 = -9.94) were better than the DS of fluconazole (3LD6 = -8.18; 5FSA = -8.79; 5TZ1 = -9.18) and ketoconazole (3LD6 = -8.16; 5FSA = -8.86; 5TZ1 = -9.06) implying high potency of TP18, TP22, TP27 and TP33 than fluconazole and ketoconazole against SDM. The anticipated LD50 and toxicity class (TC) of TP18 (500 mg/kg; TC 4), TP22 (500 mg/kg; TC 4), TP27 (1000 mg/kg; TC 4), and TP33 (1000 mg/kg; TC 4) was better than ketoconazole (166 mg/kg; TC 3). The Swiss-ADME database results revealed that TP18, TP22, TP27, and TP33 passed Lipinski’s drug-likeliness rule and demonstrated high oral absorption and bioavailability comparable to ketoconazole and fluconazole. The synthesized compounds' spectral data (FTIR, 1H-NMR, 13C-NMR, and Mass) aligned to their designed chemical structure. The antifungal activity data implies that TP18, TP22, TP27, and TP33 were better antifungal agents than fluconazole and ketoconazole against tested fungi. These findings concurred with the DS of TP18, TP22, TP27, and TP33. In conclusion, TP18, TP22, TP27, and TP33 represent a new chemical template for developing safer and better SDM inhibitors as antifungal agents.
Evaluation of Oxidative Stress level and some Antioxidant enzymes activity parameters in patients with type two diabetes mellitus
Authors: Younus Darya Assi , Mustaffa Rebaz M , Rashid Rezhna Adil , Hamad Sayfaddin Sadraddin , Salih Hemn Rasul , Othman Dlshad Saadulla , Abdulrahman Kamaran Kaiani
Published: December 2023

Diabetes, a group of metabolic disorders characterized by dysregulation of oxidative stress and elevated blood glucose levels. It has been studied with emphasis on malondialdehyde (MDA) and glutathione (GSH) levels as biomarkers of lipid peroxidation and antioxidant activity in the serum of type II Diabetes examines patients. The study involved the analysis of 105 serum samples from 75 type II diabetes patients and 30 healthy individuals. MDA and GSH levels served as measures of oxidative stress and antioxidant activity, respectively. In addition, lipid profiles were examined, which include measurements such as total cholesterol (total C), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). The results showed significantly increased MDA, total cholesterol, triglycerides and glucose levels in the diabetic group compared to controls. In contrast, GSH and HDL levels were significantly lower in diabetics. In the type 2 diabetes patient group, a correlation between glucose levels and MDA concentration was observed, while no other significant associations were found between lipid profile parameters, glucose levels and MDA or GSH levels. Studies show the complex connection between diabetes and the increase in free radicals and the corresponding decrease in antioxidant synthesis. This dynamic interaction is an important factor in the development of oxidative stress.
LC/MS/MS Method Development and Validation for the Estimation of Lasmiditan in Bulk and Pharmaceutical Formulation
Authors: Babu D.China , Alagusundaram M. , Harsha G. Sai Sri , Sing Nerwarya Shailender , Venkateshwarlu G. , Parameswari Angala , Aleesha SK.
Published: December 2023

Background: Lasmiditan is an agonist of 5HT1F receptor, acute migraine is treated and oral dose is safe and effective. No analytical methods were reported on Lasmiditan Drug. Objectives: The goal of the current project is to create a quick, effective, and reproducible LC/MS/MS method for the estimation of Lasmiditan. The mobile phase was used Acetonitrile: 0.1% formic acid (70:30) in the developed method, and it was running down a C18 column (SP) with dimensions of 150 mm, 4.6 mm i.d., and 3.5 µm at a rate of 1 mL/min. The [M+H]+ ion m/z ratio for the substance was observed in the mass spectrum was 378.24. The drug had a retention time of 2.3 minutes. The linearity range was found to be in between 12.50 ng/mL and 75 ng/mL. The regression coefficient value was found to be 0.999, which is good satisfactory value for linearity. The LOD and LOQ for baseline measurement and detection were 0.66 ng/mL and 2.22 ng/mL, respectively; the method was shown good accuracy and precision levels, and it was proved through the assay values. The method was proved as robust after deliberated changes in parameters of flow rate (±0.2mL) and organic phase (±3 mL) in mobile phase composition and values were found to be 99.50%-100.73% & 99.10%- 101.83% respectively. Conclusion: The LC/MS/MS method is more advanced and sensitive to determine the drugs at nanograms level. Hence developed method used for the regular assay. This is more sensitive, selective, and rapid for identification and quantification of LMT in the bulk and Pharmaceutical formulation.
Synthesis, Characterization, and Applications of Y2O3 Nanoparticles Synthesized via Thermal Decomposition of the [Y(Cup)2(Gly)∙2H2O] Complex
Authors: Kamble Vishal S. , Patil Sunil. S. , Khairnar Sagar L. , Patil Digambar K. , Kamble Satyajit S. , Pawara Jitendra M.
Published: December 2023

This research paper presents the synthesis and characterization of a novel Yttrium (III) complex. This complex consists of yttrium chloride hexahydrate coordinated with two primary ligands: (2Z)-2-(N-hydroxyimino)-1,2-diphenylethan-1-ol (Cupron) and glycine as the secondary ligand. The complex, denoted as [Y(Cup)2(Gly)∙2H2O], underwent thorough characterization using various analytical techniques, including elemental analysis, infrared spectroscopy (IR), ultraviolet-visible spectroscopy (UV-vis), and differential thermal/thermogravimetric analysis (TG/DTA). A noteworthy observation was made during the thermal decomposition of the complex at a relatively low temperature of 400°C. This process yielded pure Yttrium oxide (Y2O3) nanoparticles with a consistent spherical particle morphology. The structural analysis of these Y2O3 nanoparticles was carried out through Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV), thermogravimetric analysis (TG/DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Of particular significance is the antimicrobial activity exhibited by the synthesized Yttrium oxide nanoparticles. This observation suggests promising applications for these nanoparticles as potential antimicrobial agents or materials.
Evaluation of Comparative Metabolomic Profile in Cardamom elettaria and Amomum subulatum Fruits
Authors: Gopinath Arun , Yadav Sangilimuthu Alagar , D Ranjithkumar
Published: December 2023

Background: Cardamom is Queen of Spices belonging to Zingiberaceae family. The present study to reveals the comparative metabolomic profile of the two different types of cardamom such as Cardamom elettaria and Amomum subulatum. Methods: Physical parameters and chemical parameters were screened in both species. The essential oil was extracted by using Clevenger apparatus and analysed the volatile profile by GC-MS studies. Results: Capsule of C. elettaria was observed to dominant in bulk density and volatile oil content whereas A. subulatum is greater in size and shape. Oil of C. elettaria showed the good ascent of Optical rotation (+29.1), Specific gravity (1.4620), refractive index (0.927), aroma and taste. In C. elettaria and A. subulatum the terpinyl acetate, geranyl acetate, and myrcene were present in high level. As well, 1,8-cineole, pinene, 3-carene, and terpineol are the primary differentiators in both seeds with diverse therapeutic effects. Conclusion: The physico-chemical characteristics of C. elettaria and A. subulatum were contrasted in this work. α-terpinyl acetate is a lead molecule in C. elettaria. 1,8-cineoleare is rich in both essential oils. Future researchers and flavourists can use this study to improve the scent and therapeutic elements of drug repurposing.
Cyanogenic Glycoside Content and Quality Characteristic of Apricot (Prunus armeniaca) and Plum (Prunus salicina) Chungs According to Their Preparation Conditions
Authors: Bae Si-Yeon , Jang Chae Min , Park Su-Won , Lee Hyunjun , Lee Jihyun , Lee Kwang-Won , Kim Hyun-Seok
Published: December 2023

The objective of this study was to investigate changes in the cyanogenic glycoside (CN-Glc) content of apricot and plum chungs over the sugaring-ripening period and to evaluate their quality characteristics. The whole and flesh parts of the apricot and plum were mixed with sugar to a mixing ratio of 1:1 (w/w) to prepare their chungs, after which the fruit-sugar mixtures were stored for 13 months. The CN-Glc content dramatically increased within 3-4 months, reached the maximum, and gradually decreased over storage by 13 months. The apricot and plum chungs with seeds exhibited much higher CN-Glc contents than those without seeds. All chungs stored for 10 months were filtrated and treated for 30 min at 85oC to measure their quality characteristics. Similar soluble solid contents (53.4- 53.6oBx) were found in all chungs. The apricot and plum chungs without seeds exhibited the higher concentrations of total carbohydrate, organic acid, and total polyphenolic compounds than those with seeds. In addition, the color of the apricot and plum chungs without seeds was darker and deeper yellow than those with seeds. Overall, the apricot and plum flesh may be better for producing the stone fruit chungs with minimal CN-Glc content and better nutrition.
Quality Characteristics of Cookies Added with Octenyl Succinyl Anhydride-Modified Wheat Starch
Authors: Chae Rin , Jeong Gyeong A , Kim Hyun-Joong , Lee Chang Joo
Published: December 2023

This study established optimal cookie conditions by varying the amount of modified starch treated with octenyl succinic anhydride (OSA). It also investigated the quality and digestion characteristics of the cookies produced. The moisture content increased as the amount of OSA-modified starch added to the cookies increased. As for cookie color brightness, the redness and yellowness decreased as the OSA-modified starch content increased. The spread factor and hardness of the cookies showed the most similar results for control and OSA: 20%. As the amount of OSA-modified starch added to cookies increased, RS tended to increase. It was found that OSA-modified starch cannot easily replace wheat flour completely and that the optimal amount of OSA-modified starch added to cookies is 20%. OSA-modified starch can be used not only as a cookie but also as a low-calorie food ingredient.
Data-Based Production Simulation Study for Robot Automation of Food Transport and Disassembly Manufacturing Process
Authors: Kim Tae Hyong , Baek Seunghoon , Kwon Ki Hyun
Published: December 2023

This study selected two labor-intensive processes in harsh environments among domestic food production processes. It analyzed their improvement effectiveness using 3-dimensional (3D) simulation. The selected processes were the “frozen storage source transfer and dismantling process” (Case 1) and the “heavily loaded box transfer process” (Case 2). The layout, process sequence, man-hours, and output of each process were measured during a visit to a real food manufacturing factory. Based on the data measured, the 3D simulation model was visually analyzed to evaluate the operational processes. The number of workers, work rate, and throughput were also used as comparison and verification indicators before and after the improvement. The throughput of Case 1 and Case 2 increased by 44.8% and 69.7%, respectively, compared to the previous one, while the utilization rate showed high values despite the decrease, confirming that the actual selected process alone is a high-fatigue and high-risk process for workers. As a result of this study, it was determined that 3D simulation can provide a visual comparison to assess whether the actual process improvement has been accurately designed and implemented. Additionally, it was confirmed that preliminary verification of the process improvement is achievable.
Non-generic bound states in the continuum in waveguides with lateral leakage channels
Authors: Zhang Nan , Lu Ya Yan
Published: December 2023

For optical waveguides with a layered background which itself is a slab waveguide, a guided mode is a bound state in the continuum (BIC), if it coexists with slab modes propagating outwards in the lateral direction; i.e., there are lateral leakage channels. It is known that generic BICs in optical waveguides with lateral leakage channels are robust in the sense that they still exist if the waveguide is perturbed arbitrarily. However, the theory is not applicable to non-generic BICs which can be defined precisely. Near a BIC, the waveguide supports resonant and leaky modes with a complex frequency and a complex propagation constant, respectively. In this paper, we develop a perturbation theory to show that the resonant and leaky modes near a non-generic BIC have an ultra-high Q factor and ultra-low leakage loss, respectively. Recently, many authors studied merging-BICs in periodic structures through tuning structural parameters. It has been shown that resonant modes near a merging-BIC have an ultra-high Q factor. However, the existing studies on merging-BICs are concerned with specific examples and specific parameters. Moreover, we analyze an arbitrary structural perturbation given by δF(r) to waveguides supporting a non-generic BIC, where F(r) is the perturbation profile and δ is the amplitude, and show that the perturbed waveguide has two BICs for δ > 0 (or δ < 0) and no BIC for δ < 0 (or δ > 0). This implies that a non-generic BIC can be regarded as a merging-BIC (for almost any perturbation profile F) when δ is considered as a parameter. Our study indicates that non-generic BICs have interesting special properties that are useful in applications.
Refractive X-ray optics: towards wavelengths of 13.5 nm and beyond
Authors: Demin Gleb , Korneev Viktor , Glagolev Petr , Djuzhev Nikolay , Snigirev Anatoly , Bespalov Vladimir
Published: December 2023

In this work we analyze the possibility of using refractive lenses for X-ray lithography in the wavelength range λ=2-20 nm, where the absorption of radiation in the lens material has a significant impact on the image quality. The general scheme of image formation in projection refractive X-ray optics using a composite objective lens consisting of biconcave elementary lenses is considered. By means of the analytical solution and finite-element simulation model, possible ways to obtain the lens transmission function taking into account the absorption of X-rays were investigated. A lens based on a beryllium (Be) thin film with a complex refractive index n=0.989+0.0015i was chosen to estimate its optical properties at a wavelength of 13.5 nm. Two mechanisms of blurring of the X-ray beam at the lens focus were studied: a mechanism associated with X-ray diffraction and a mechanism based on the absorption of X-ray radiation in the lens material. The possibility of reducing X-ray absorption by switching to diffractive and kinoform lenses is being explored. A method for constructing an image in a diffraction lens with a 4-fold reduction taking into account X-ray absorption is presented. It was shown that to obtain image resolution in the range of 20-40 nm, composite kinoform lenses consisting of a small number (N=3-6) of elementary lenses can be used.
Typische Profile digitaler Kompetenzen: Eine clusteranalytische Untersuchung digitaler Kompetenzen im Arbeitskontext
Authors: Merchel Robin , Kampschulte Kathleen , Nauth Kathrin , Pöppelbuß Jens
Published: December 2023

Typologien reduzieren die Vielfalt menschlicher Merkmale auf eine geringe Zahl an Merkmalsausprägungen, die die Wirklichkeit vereinfachend abbilden und so die Ableitung organisationaler Interventionen ermöglichen. Für den Umgang von Menschen mit der Digitalisierung wurden bereits mehrere Typologien mit vier bis sieben Typen bzw. Clustern aufgestellt, wobei dies z. B. auf Basis der Intensität der Mediennutzung, der Begeisterung für digitale Umbrüche oder der Fähigkeiten der Beschäftigten geschah. In der vorliegenden Arbeit werden neun digitale Kompetenzen von n = 645 Beschäftigten im Rahmen einer Fragebogenstudie (Oktober 2021–April 2022) erfasst. Mithilfe einer Clusteranalyse werden vier typische Profile digitaler Kompetenzen identifiziert, die als (1) begeistertes, (2) balanciertes, (3) naives und (4) ablehnendes Cluster bezeichnet werden. Die vier Cluster zeigen Zusammenhänge zu den wahrgenommenen organisationalen Lernmöglichkeiten, zum Techno-Engagement und zum Persönlichkeitsmerkmal der Offenheit. Sie spiegeln bisherige Forschung zur Typologisierung von Beschäftigten im Umgang mit der Digitalisierung präzise wider. Somit stellen sie ein generalisierbares, stabiles und bedeutsames Muster dar, das für organisationale Interventionen zur Steigerung der digitalen Kompetenzen und der Bereitschaft für digitale Umbrüche genutzt werden kann.