bluuebunny/crossref_metadata_2025 huggingface dataset:
Nível de conhecimento dos estudantes do curso de graduação em medicina de faculdade particular do Piauí sobre cigarros eletrônicos
Authors: Pessoa Lucas Cerqueira , Oliveira Maria Clara e Vasconcelos , Lima Maurilio Batista
Published: May 2023

O cigarro eletrônico vem despontando como uma opção ao cigarro convencional, e é considerado por alguns uma alternativa para quem deseja parar de fumar, embora não haja comprovação de sua eficácia para esta finalidade. O objetivo desse estudo foi levantar o nível de conhecimento sobre os cigarros eletrônicos dos estudantes do Curso de Graduação em Medicina do Centro Universitário Novafapi. Trata-se de pesquisa transversal de caráter descritivo e analítico, com 219 estudantes onde foi utilizado um questionário com perguntas sobre o conhecimento dos acadêmicos a respeito dos malefícios do cigarro eletrônico, posteriormente os dados foram analisados com estatística descritiva. A análise dos resultados demonstrou que 73% se identificam como do gênero feminino, faixa etária variou de 18 a 36 anos, com mediana de 22 anos, sendo 170 alunos do primeiro ao sexto período e 49 alunos do sétimo ao decimo segundo período. Em relação ao hábito de fumar, 162 estudantes afirmaram nunca terem fumado, 24 estudantes eram ex-fumantes e 33 afirmaram que eram fumantes. A grande maioria dos estudantes relatou não ter tido contato com o tema durante o curso de graduação. Da mesma forma, a grande maioria dos estudantes declarou não se sentir preparada para responder a questionamentos de pacientes sobre o uso de cigarros eletrônicos. Os resultados deste estudo apontam para a necessidade de o currículo contemplar este assunto na capacitação dos futuros médicos, de forma a capacitá-los a orientar seus pacientes sobre riscos e benefícios da utilização dos cigarros eletrônicos.
Fatores intervenientes experienciados pela população de refugiados no acolhimento do serviço público de saúde: revisão integrativa
Authors: Santos Maria Taís da Silva , Lima Ana Yasmim Gomes de , Silva Maria Fernanda Bandeira da , Andrade Erlaine da Silva , Medeiros Larissa Mercielly Nóbrega , Candeia Victor César Urquiza , Nóbrega Mércia de França , Carvalho Thiozano Afonso de , Pinto Laís Maria Campos , Fernandes Marcelo Costa
Published: May 2023

O objetivo deste estudo foi analisar os fatores intervenientes experienciados pela população de refugiados no acolhimento ofertado pelo serviço público de saúde. Trata-se de uma revisão integrativa de literatura, em que foi efetuada uma pesquisa eletrônica no Portal de Periódicos CAPES, fazendo o entrecruzamento dos descritores: Refugiados, Direito à Saúde e Assistência à saúde. Após as buscas, encontrou-se 2 611 textos, que com a leitura na íntegra selecionou-se 18 para a amostra final. Foi possível demonstrar as barreiras vivenciadas nos centros de saúde, incluindo a falta de informações sobre os sistemas de saúde, dificuldade na comunicação e compreensão do idioma, divergências culturais, questões legais e de proteção, além da falta de recursos financeiros. Priorizou-se esse campo de investigação, pelo fato de existirem dificuldades e lacunas no conhecimento sobre o acesso à saúde dos refugiados, bem como pelos desafios para a adesão de medidas capazes de garantir uma assistência qualificada.
Análise situacional da atenção primária de saúde ribeirinha da cidade Manaus/AM – um relato de experiência
Authors: Torres Leoncio de Oliveira , Barbosa Luis Gustavo Rodrigues , Faria Ana Clara Rodrigues , Torres Anna Clara Silva , Lima Gabrielle Mendes
Published: May 2023

A promoção da equidade é um dos princípios do Sistema Único de Saúde (SUS) e tem relação direta com os conceitos de igualdade e de justiça social. Nesse contexto, as Equipes de Saúde da Família Ribeirinhas (ESFR) e as Equipes de Saúde da Família Fluviais (ESFF) emergem como adaptações do sistema público de saúde frente às necessidades e especificidades de importante parcela da população brasileira – os ribeirinhos. O estudo trata-se de relato de experiência que aborda de forma descritiva-reflexiva as impressões colhidas durante um período de dez dias no mês de maio de 2022 por dois acadêmicos de medicina acerca do trabalho realizado em uma Unidade Básica de Saúde Fluvial (UBSF), responsável por atender às comunidades ribeirinhas do baixo Rio Negro, adstritas à área rural do Município de Manaus, no estado do Amazonas. Ao longo da experiência, foi possível analisar a rotina de um serviço altamente adaptado ao meio ambiental e social no qual está inserido e a atuação de uma equipe multidisciplinar intimamente conectada aos moradores locais. Foram identificados desafios e dificuldades enfrentados pela UBSF Ney Lacerda, alguns inerentes à prática do cuidado na população das águas e outros não generalizáveis, logo permitem uma reflexão sobre a necessidade da criação de novas estratégias e da reestruturação dos programas de saúde direcionados a populações específicas.
O papel do acompanhante no trabalho de parto
Authors: Paiva Thaisy Gonçalves Sampaio , Leal Marly Sâmia Mendes , Silva Vicerlândia Vieira da , Silva Yone Mara Rocha Santos e
Published: May 2023

O presente estudo objetiva investigar as evidências na literatura acerca da importância e benefícios do acompanhante durante o trabalho de parto. Trata-se de uma revisão integrativa da literatura, realizada nas bases de dados Literatura Médica (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de Dados de Enfermagem (BDENF), via Biblioteca Virtual de Saúde e Scientific Eletronic Library Online (SCIELO) com os descritores em saúde que incluiu publicações de 2015 a 2022. Por fim, realizou-se leitura na íntegra, com fichamento de cada artigo, ficando uma amostra de 11 obras, que deram origem a duas categorias semânticas. A literatura pesquisada evidencia a importância da presença do acompanhante no trabalho de parto e como é amplamente reconhecida. A presença do acompanhante contribui de forma positiva no momento do parto, o deixando mais brando e especial, e com as modificações feitas nas redes de saúde vem evidenciando vários benefícios tais como o suporte físico e emocional, na intermediação e apoio informacional, no fortalecimento da relação familiar, entre outros. A presença de um acompanhante durante o parto é eficaz, pois participam ativamente do processo do nascimento realizando ações de apoio e proporcionando vínculos, segurança e inúmeros benefícios, contribuindo para uma boa evolução do parto. Assim, faz-se necessário o estímulo a essa intervenção junto à equipe e instituições de saúde.
Frost Tolerances of Turkish Olive (Olea europaea L.) Cultivars
Authors: METE Nurengin , GÜLEN Hatice , ÇETİN Öznur , HAKAN Mehmet , GÜLOĞLU Uğur , KAYA Hülya , ULUÇAY Nurcan
Published: May 2023

The motherland of the olive is considered as east of the Mediterranean Basin. Turkey is partly located within this basin having a rich source of biodiversity. Olive growing in Turkey is carried out in the Aegean, Marmara, Mediterranean, Southeastern Anatolia and Black Sea Regions. Climatic factors determine the cultivation limits of olive which is not very selective in terms of soil demand. In regions where olives are grown, the Mediterranean climate prevails. Winters are warm and rainy in the region, while summers are hot and dry. On the other hand, severe cold damage in some years can cause significant damage especially in the inner parts of Aegean, Marmara and Black Sea Regions. As a matter of fact, it is known that 31.8% of olive plantations in Turkey are exposed to occasional frost damage. This situation has revealed the necessity of determining the varieties with high frost tolerance and determining the suitable varieties for the regions where cold damage may occur. In the study, 40 registered olive cultivars in “Kemalpaşa Olive Germplasm Bank" in Bornova Olive Research Institute, in İzmir were screened in terms of frost tolerance. To evaluate the frost tolerance (LT50) of cultivars, as estimated by ion leakage (electrical conductivity), leaf samples taken in six different periods over two years were exposed to temperatures at +4 °C (control), -2 °C, -5°C, -8 °C, -11°C, -14 °C, -17 °C and -20 °C. In conclusion; it has been determined that frost tolerance of olive varieties revealed significant variability both genetically and seasonally. Butko, Memeli, Otur, Gemlik, Sinop No 5, Yün Çelebi, Kara Yaprak, Satı and Sarı Ulak were determined as cultivars that were more tolerant of frost. Sinop No 1, Marantelli, Ayvalık, Görvele, Çakır, Samsun Tuzlamalık, Erkence, Saurani, Eşek Zeytini (Tekirdağ), Kan Çelebi, İzmir Sofralık, Çilli, Samsun Yağlık, Domat, Eşek Zeytini (Ödemiş), Saçaklı Otur, Sinop No 4, Memecik, Nizip Yağlık, Tekirdağ Çizmelik and Patos were found to be moderately tolerant cultivars while Edincik, Sinop No 6, Çekişte, Mavi, Kiraz, Kilis Yağlık, Çelebi (İznik), Trabzon Yağlık, Uslu and Girit olive cultivars were grouped as cultivars having low tolerance to frost. In addition, data showed that cold acclimation in the olive is quite important, and exposure to low temperatures for a certain period of time has significantly increased the frost tolerance. However, this condition was not stable and could rapidly become reversed when temperature reached to the point at which adapdation did not ensure.
Viranşehir İlçesindeki Süt Sığırı İşletmelerin Kimi Yapısal Özelliklerinin Süt Verimine Etkisi
Authors: DELEBE Çiğdem , YAZGAN Kemal
Published: May 2023

Bu çalışmada, Şanlıurfa ilinin Viranşehir ilçesinde Damızlık Sığır Yetiştiricileri Birliği (DSYB)’ne üye olan süt sığırı işletmelerinin yapısal durumları ve işletme sahiplerine ilişkin bazı özellikler belirlenerek bunların süt verimine etkisi araştırılmıştır. Çalışmada ilçedeki 262 işletme sahibi ile yapılan anketlerden elde edilen veriler ve DSYB’den temin edilen süt verim kayıtları kullanılmıştır. Anketlerden alınan cevaplar ile yetiştiricilerin sosyal durumları, hayvan barınaklarının özellikleri, yetiştirme uygulamaları, yem temini ve besleme yöntemleri istatistik yöntemlerle değerlendirilmiştir. Araştırmada yetiştirici yaş ortalamasının 41.9 ± 13.14 ve ilçede hayvan başına düşen aylık ortalama süt veriminin 351.28±86.33 kg olduğu saptanmıştır. Süt verimi ile işletme sahiplerinin yaşları ve ailedeki erkek çocuk sayısı arasındaki ilişkinin düşük ve pozitif yönde olduğu (Sırasıyla r=0.1529 ve r=0.1380), buna karşılık ailede tarım dışı işlerle uğraşan kişi sayısı arasındaki ilişkinin ise düşük ve negatif yönde olduğu (r=-0.1693) belirlenmiştir. Duraklı ya da duraksız ahırlarda barındırma şekli, barınaklarda kullanılan çatı materyali ve işletme büyüklüğü gibi faktörlerin süt verimine etkisi önemli bulunmuştur (P
PEMANFAATAN E – COMMERCE UNTUK UMKM DI DESA PASIR WETAN KABUPATEN BANYUMAS
Authors: Solikhah Nur Amalia , Fitriana Saghifa , Maarif Vadlya
Published: May 2023

Kemajuan di bidang teknologi, komputer, dan telekomunikasi mendukung perkembangan teknologi internet. Dengan internet pelaku usaha tidak lagi mengalami kesulitan dalam memperoleh informasi apapun, untuk menunjang aktivitas usahanya, bahkan sekarang cenderung dapat diperoleh berbagai macam informasi. Penggunaan internet oleh UMKM berubah dari fungsi sebagai alat untuk pertukaran informasi secara elektronik menjadi alat untuk aplikasi strategi bisnis, seperti: pemasaran, penjualan, dan pelayanan pelanggan. Pemasaran di Internet cenderung menembus berbagai rintangan, batas bangsa, dan tanpa aturan-aturan yang baku. UMKM menghadapi berbagai permasalahan dalam pemasaran, penjualan, dan pelayanan pelanggan terkait dengan e-commerce, seperti keterbatasan pengetahuan dan keterampilan, masalah kepercayaan konsumen, persaingan yang ketat, masalah logistik, dan teknologi yang terus berkembang. Tujuan dari pengabdian ini untuk menciptakan inovasi dalam pemasaran produk-produk UMKM sehingga menjadi produk yang banyak dikenal luas dan dapat meningkatkan omset penjualan. Metode yang dilakukan terdiri dari pelatihan, pendampingan, difusi teknologi dalam pemasaran produk melalui e-commers. Hasil yang diperoleh adalah terciptanya inovasi pemasaran produk UMKM, mitra mendapatkan keterampilan dan pengetahuan, hingga diharapkan dapat meninggkatkan penjualan produk secara signifikan.
Aplikasi Penentuan Kesegaran Ikan Bandeng Menggunakan Metode Convolution Neural Network
Authors: Suprianto Suprianto , Lestari Dwi Shintya , Simung Okky Herodion
Published: May 2023

Ikan bandeng merupakan ikan konsumsi yang salah satunya paling banyak dijual di Kota Tarakan. Ikan termasuk ke dalam makanan yang cepat menurun kualitas kesegarannya. Salah satu cara untuk melihat tingkat kesegaran ikan adalah dengan melihat pada bagian matanya. Bagi orang yang telah terbiasa untuk mengenali kesegaran ikan tentunya tidak akan ada kendala, tetapi untuk orang awam akan menjadi kendala tersendiri. Permasalahan ini dapat diselesaikan dengan memanfaatkan teknik pengolahan citra digital, maka dari itu diperlukan sebuah aplikasi untuk menentukan tingkat kesegaran ikan bandeng melalui citra mata ikan dengan menggunakan metode CNN (Convolutional Neural Network). Cara kerja metode yaitu mengambil nilai RGB citra foto pada mata ikan bandeng, kemudian melakukan konvolusi dengan menggerakkan sebuah karnel filter berukuran 3 x 3 pada gambar, sehingga komputer akan menemukan sebuah informasi respresentatif baru yaitu dari hasil perkalian antara bagian gambar dengan filter yang digunakan, hingga akhirnya didapatkan 2 nilai untuk klasifikasi. Hasil analisa dengan menggunakan 24 data uji, dimana hasil akurasi deteksi kesegaran ikan bandeng dengan menu deteksi kamera flashlight dan jarak ± 5 cm yaitu 87,5 %, deteksi dengan kamera tanpa flashlight dan jarak ± 5 cm yaitu 66,67 %, deteksi dengan kamera flashlight dan jarak ± 10 cm yaitu 29,17 %, deteksi dengan kamera tanpa flashlight dan jarak ± 10 cm yaitu 66,67 %, dan deteksi dari galeri 91,67 %. Setiap uji menggunakan 24 data uji.
Factors of Smart Mobility Success using DeLone McLean and E-Government Adoption Models
Authors: Haryono Hernu , Amin Faris Muslihul , Ulinnuha Nurissaidah
Published: May 2023

E-government is an information systems for public services with an easily accessible and efficient system used by the government. This research aims to find out the factors influencing success and adoption using the DeLone McLean model and the E-Government Adoption Model (GAM) in the implementation of the TransportasiKu application of the Surabaya Transportation Agency. This research used a quantitative approach by collecting data through questionnaires using a measurement scale, namely the Likert scale. The sample collection technique for this research was simple random sampling with 100 respondents in total samples. The technique of data analysis in this research used SEM-PLS. The results of this study found that of the eight hypotheses proposed, five were accepted while the other three were rejected. Computer Self-Efficacy and Perceived Trust positively and significantly affect E-government Adoption. Information Quality has a positive and meaningful effect on the Intention to Use. E-government Adoption and Intention to Use positively and significantly affect Net Benefit. Meanwhile, Perceived Awareness of E-government Adoption, System Quality, and Service Quality towards Intention to Use results are not significant.
PERENCANAAN STRATEGIS SISTEM INFORMASI DENGAN METODE WARD AND PEPPARD PADA BISNIS RETAIL (STUDI KASUS : ASIA PLASA TASIKMALAYA)
Authors: Ramdhani Hadianto Harry , Aristi Gea
Published: May 2023

Asia Plasa merupakan salah satu mall terbesar di Priangan Timur. Sistem informasi yang ada di masing-masing cabang berdiri sendiri-sendiri sehingga para stakeholder tidak bisa dengan mudah melihat perkembangan yang ada. Masih banyak para stakeholder yang belum memahami pentingnya kepatuhan terhadap policy, standard, dan procedure dari suatu proses bisnis. Masalah yang kini dihadapi perusahaan tersebut adalah adanya keraguan dalam pengembangan teknologi informasi. Oleh karena itu perlu dibuat perencanaan strategis sistem informasi yang mengacu dengan strategi bisnis perusahaan. Strategi SI/TI yang selaras dengan strategi bisnis perusahaan dapat meningkatkan efisiensi dan efektifitas dalam mencapai visi dan misi perusahaan. Kelebihan metode Ward and Peppard sendiri dibandingkan dengan metode lain adanya analisis bisnis eksternal dimana memperhitungkan faktor luar perusahaan yang mempengaruhi proses bisnis perusahaan, adanya pemisahaan antara definisi SI dan TI sehingga memudahkan strategi SI/TI untuk dimengerti, Hasil dari penelitian ini adalah telah diketahui sistem informasi yang berjalan di bisnis retail Asia Plasa. Telah dilakukan penerapan metode Ward and Pepard pada perencanaan strategi sistem informasi di Asia Plasa dengan menghasilkan analisis SWOT, strategi SWOT, Mc.Farlan Grid, Analisis PEST, analisis lima persaingan porter, value chain, Critical success factor, portofolio aplikasi  Telah dihasilkan portofolio aplikasi yang digunakan untuk masa mendatang sebanyak 24 aplikasi.
Respiratory viruses in infancy and rapid RSV diagnostics
Authors:   , Zuurbier Raymond Petrus (Roy)
Published: May 2023

In this thesis I have described the use of different point-of-care tests (POCTs) on respiratory syncytial virus (RSV) as well as the burden and dynamics of respiratory viruses in infants.
In part one of the thesis I described the use of different POCTs on RSV in infants and in older adults. Our studies were performed within our prospective international RESCEU birth cohort and older adult cohort in which the primary objective was to determine the burden of RSV.
In Chapter 2 the performance of rapid antigen detection test BinaxNOW® RSV (BN) was evaluated. Low sensitivity was found of rapid antigen test BN for RSV detection in infants, with a sensitivity of 7.6% (95% CI 3.3-16.5%), specificity was 100% (95% CI 96.2-100%).
The performance of a molecular rapid detection test in older adults was assessed in Chapter 3. The performance of Xpert® Xpress Flu/RSV compared to routine RT-PCR is high for RSV detection in home-dwelling older adults. In all cases with discordant results for the two assays, viral load was low.
In part two of this thesis I discussed the burden and dynamics of respiratory viruses in infants. Results are based on a hospital based cohort and two different birth cohort studies.
In Chapter 4 we examined the occurrence of respiratory viruses in infants during the first year of life. Rhinovirus (RV) was negatively associated with ARTI (aOR 0.41 [95% CI 0.18-0.92]). Human metapneumovirus, RSV, parainfluenza (PIV) 2 and 4, and human coronavirus (HCoV) HKU1 were positively associated with ARTI. Asymptomatic RV in early life was, however, associated with increased susceptibility to and recurrence of ARTIs later in the first year of life (Kaplan-Meier survival analysis: p=0.022).
The methods of the prospective international RESCEU birth cohort study was described in Chapter 5. The primary outcome was the incidence of RSV associated ARTI, medically attended (MA)-ARTI, and hospitalisation in the first year of life.
The results of this study were shown in Chapter 6. In total 9,154 infants born between July 2017 and April 2020 were followed during the first year of life of whom 993 participated in the nested active surveillance. The incidence of RSV hospitalisation in the total cohort was 1.8% (95% CI 1.6-2.1). About half of hospitalisations for respiratory tract infection in the first year of life were associated with RSV. The majority (57.9%) of RSV hospitalizations occurred in children <3 months of age. Incidences of RSV infection and medically-attended RSV infection in the active surveillance cohort were 26.2% (95% CI 24.0-28.6) and 14.1% (95% CI 12.3-16.0), respectively.
The burden of influenza and RSV in infants of the Dutch part of RESCEU was discussed in Chapter 7. RSV was responsible for the highest number of ARTIs in both non-hospitalised and hospitalised infants, especially during the first months of life. Incidence of influenza-ARTI was low compared to RSV-ARTI.
Mechanisms of Sapropel Formation
Authors:   , Dirksen Jan Pieter
Published: May 2023

In paleoceanography, physical and chemical processes of the oceans are studied throughout geological history. The sediments that constantly accumulate on the sea floor reflect the oceanographic conditions at the time of deposition. These geological records can be collected using sediment cores, providing a window into the past. In January 2016, sediment core 64PE406-E1 was collected in the eastern Mediterranean Sea, near Cyprus, which inspired the research presented in this thesis. The geological record of the Mediterranean sea contains alternating dark organic rich layers, so-called sapropels, and gray mud layers. We study the oceanographic mechanisms that cause sapropel formation in the Mediterranean Sea, as well as organic rich deposits in the Black Sea. The key to sapropel formation is water circulation and organic matter. When the circulation slows down and sufficient organic matter is produced, the bottom water becomes anoxic, i.e. lacking oxygen. Any organic matter that sinks to the sea floor is preserved, hence the dark colour. Due to the lack of oxygen, life does not disturb the sediments on the sea floor. Consequently, these sediments provide a remarkably fine structure of layers and a high resolution record of past oceanographic conditions.
In the Mediterranean Sea, sapopels are found at a regular time interval of typically 21 thousand years, equal to the period of Earth's precession. Indeed, Earth's motion is an important drivers of climate change on geological timescales. In particular, Earth’s precession impacts the monsoon intensity, which in turn determines the Nile discharge.
The Black Sea was cut-off from the Mediterranean during the last ice age, since the sea level was not high enough for water to pass the shallow Bosporus strait. At the end of the ice age, the sea level increased, allowing inflow from the Mediterranean Sea. The in-flowing water sank to the deep parts of the basin, supplying extra nutrients into the Black Sea. Consequently, production of organic matter increased, causing the formation of an organic rich layer.
Previous studies often do not describe transient behaviour. In contrast, we present a transient box model that captures oceanic circulation. In such a model the basin divided in a small number of boxes, each representing an important water mass. They interact by exchanging salt, heat, oxygen and nutrients. The great advantage of this approach is that it gives insight into the fundamental processes. The model describe long term (> 100 kyr) processes on a one year resolution, while being computationally light.
We conclude that sapropel formation in the Mediterranean Sea is an inherently transient process. In the Black Sea, a steady state is reached with a high organic carbon burial rate, resulting in a single organic rich deposit. A monotonic sea-level curve shows the best match with the geological data of the Black Sea. We find that our model describes the main trends found in geological records of both the Mediterranean Sea and Black Sea.
Nurses' Moral Courage Scale: Adaptation, Validity and Reliability Study
Authors: AYAZ Ebru , AKKUŞ Yeliz
Published: May 2023

Aim: This study’s aim was to evaluate the psychometric properties of the Turkish version of the Nurses’ Moral Courage Scale. Materials and Methods: This was a methodological study. The study sample consisted of 250 nurses. Data were collected by using a socio-demographic characteristics form and the Nurses’ Moral Courage Scale (NMCS). Turkish translation and content validity studies were conducted for scale validity, confirmatory factor analysis (CFA) was used to ensure construct validity and invalidity analysis, and Cronbach's α coefficient was used to evaluate internal consistency in reliability analysis. Results: The mean age of the participants was 29.02±4.76 years and 67.6% were women. The Kaiser-Meyer-Olkin was 0.934, for which the Bartlett’s test of sphericity was significant (chi-square=3639.923. p=0.001). These values were evaluated as the sample size was sufficient and the data set was suitable for factor analysis. Some indices were used to examine the fit of the model of the Moral Courage Scale of Nurses. The chi-square/degrees of freedom, Groningen Frailty Indicator, Adjusted Composite Financial Index, Composite Financial Index, root mean square error of approximation, and standardized root mean square residual were 4.10, 0.98, 0.98, 1.00, 0.11, and 0.06, respectively. The results of the confirmatory factor analysis showed a good model fit. The total scale had a Cronbach’s alpha of 0.952. Conclusion: The results of this study indicate that the Turkish version of the Nurses’Moral Courage Scale is a valid and reliable scale. However, further studies are needed to refine its psychometric properties.
Public Financial Management in martial time and post-war reconstruction of Ukraine: scientific support of transformations
Authors:   SESE “The Academy of Financial Management”, IEFYMENKO Tetiana
Published: May 2023

Introduction. The scale of pandemic and war in Ukraine was not fully forecasted, but the crisis phenomena of these disasters have specific signs. One of the priorities of the tax and budget policy is resilience to threats, both foreseeable and unforeseeable. Problem Statement. The full-scale Russian invasion of Ukraine has led to significant changes in the resource base, economic potential and the common system of public finances, these can no longer function on pre-war principles. New realities, both internal and external, have emerged; it is impossible to ensure the successful development of the state without scientific understanding of them. Purpose. Justification of directions for the formation of internal pillars of stability and security of the economic development of Ukraine through transformations in Public Financial Management (PFM) during the period of martial law and post-war reconstruction. Methods. Based on trends in statistical indicators, a comparative analysis of national anti-crisis reforms in the field of public finances was conducted. The methodology of the system approach, methods of factual, situational analysis and synthesis were used. Results. Ukraine's acquisition of the status of a candidate for the EU membership, the modern realities of statehood and national economy recovery amid when the signs of fundamental turmoil in the global economic space, require significant changes in the PFM. It is necessary to rethink from scientific perspective and adjust the policy of countering threats of global and regional economic and social contradictions. International discussions on the plans for the post-war reconstruction of Ukraine prove the still uncertain, extremely multidimensional picture of the development of various components of the national socio-economic system. The amount of external financial support will depend on whether the measures to improve PFM during the period of martial law, as well as post-war reconstruction, will be interconnected, subordinated according to the space-time vector, etc. Conclusions. International financial institutions provide resources to conflict-prone and fragile states not only to correct imbalances, but also to build confidence during crisis situations when countries risk losing their ability to borrow on open markets. Taking into account the escalation of the geopolitical conflict associated with the full-scale Russian invasion of Ukraine, transformations in the fiscal sphere should be aimed at winning the war, preserving the territorial integrity of the state, supporting economic sovereignty and combating corruption, stimulating investment processes in the post-war recovery.
The impact of globalization on the dynamics of inflation
Authors:   Kyiv National Economic University named after Vadym Hetman, KYRYLENKO Volodymyr , KHOKHYCH Dmytro ,   Kyiv National Economic University named after Vadym Hetman
Published: May 2023

Introduction. The article studies the impact of globalization on the dynamics of inflation due to increased integration between developed economies and emerging countries in the period 1990-2022, its causes and effects. Problem Statement. Based on the analysis of statistical data, it was established that global inflation in the world economy has a direct impact on domestic inflation in emerging countries, as well as a pronounced structural character in developed countries. This means that even minor disruptions in global trade channels can cause inflation. Purpose. Explaining the impact of globalization on the level of inflation in developed countries and commodity economies through the expansion of trade integration, the strengthening of the role of emerging markets, price competition and the increase in the volatility of interest rates. Methods. According to the results of a dispersion analysis, a hypothesis of the existence of a connection between the components of globalization channels and inflation indicators, which determine the volatility of prices for goods and services in the medium term was investigated . Results. The global components of each inflation indicator are analyzed for the full sample of advanced economies and emerging markets. CPI and producer price index are found to have a significant common global component, accounting for 40% of the difference in CPI inflation and 52% in producer price index inflation of the countries in the sample. However, the role of the common component is much smaller for core inflation and wage inflation. The first main component of inflation accounts for about 21-26% of the variation in inflation for different samples. Conclusions. The increase in the global component of inflation over the past two decades can be explained by major global crises arising from high volatility of commodity prices, greater sensitivity of countries to global shocks due to increased trade or financial integration, or closer direct links between economies. The effect of the transfer of global inflation on domestic prices requires that the central bank should conduct a tighter monetary policy towards achieving the price stability.
Modern determinants of assessing the risk of legalization of criminal proceeds in banks
Authors:   Odesa National Economic University, KOVALENKO Viktoriia , YEHOROVA Anastasiia
Published: May 2023

Introduction. In recent years, there has been a tendency to simultaneously increase requirements in terms of reserve capital, combating money laundering and terrorist financing, which has led to a significant increase in the corresponding costs for banks around the world. Banks that provide services such as depositing, lending, transferring funds or assets from one institution to another without taking into account geographical restrictions are most often used for money laundering. Problem Statement. It has been proven that the entrenchment of shadow schemes by economic entities conducting various operations, the introduction of the latest technologies into the financial sphere, as well as the rapid development of the cryptocurrency market have led to a growing trends in legalization of criminal proceeds involving financial institutions. Purpose. Generalization of the key provisions and practices of international standards, analysis of the use of a risk-oriented approach by countries in ensuring countermeasures against money laundering and terrorist financing, systematization of the provisions of risk management of money laundering, financing of terrorism and proliferation of weapons of mass destruction in foreign practice and their introduction into domestic banking practice. Methods. General scientific and special methods are used: analysis, synthesis, grouping, description, comparison, theoretical generalization and cluster analysis. Results. The factors that form the risks of legalization of criminal proceeds are studied by such components as threats, vulnerability and consequences. The main components of the risk management system of the legalization of criminal proceeds are singled out, namely: stages of identification and analysis of the risk of legalization of criminal proceeds , principles, functions, risk assessment methods, security systems and strategies for managing the risks of legalization. The article proposes a methodology for assessing the risk of legalization of criminal proceeds in banks using the clustering method. Conclusions. The national money laundering risk assessment system should be based on a unified approach that provides for the identification of clients of financial institutions, the processing of information by regulatory and supervisory authorities, supervision by regulatory authorities and financial intelligence units and the assessment of AML/CFT risks, the comparison of data of financial institutions with data of law enforcement agencies to determine the vulnerabilities of the system of combating the legalization of criminal proceeds and financing of terrorism. Threats caused by the latest state of operation of Ukrainian banks, the development of measures to further reduce their involvement in money laundering and terrorist financing schemes require further research.
Utilization of Yellow Shells (Cypraea moneta) in the Treatment of Cadmium Heavy Metal (Cd) Waste
Authors: Azkiya Noor Isnaini , Chrisnandari Rosita Dwi , Witasari Wianthi Septia
Published: May 2023

Cadmium (Cd) metal is a heavy metal that can cause environmental pollution if its levels are above the environmental quality standard value. Generally, industrial wastes such as paper industry waste contain heavy metal Cd with levels reaching 0.026 ppm. Meanwhile, the quality standard for Cd metal in the environment is 0.005 ppm. For this reason, it is necessary to process it to reduce the levels of Cd metal in the waste before being discharged into the environment. One way that can be used to reduce the levels of Cd metal is by adsorption method using Cypraea moneta clamshells containing chitin. This study used variations in the particle size of the shellfish adsorbent of 6 and 12 mesh. In addition, the ratio of the amount of adsorbate and adsorbent (mg:mg) is 1 : 0.5x106; 1 : 1x106; and 1 : 1.5x106. Based on the results obtained, it showed that the use of shellfish as an adsorbent was able to reduce Cd metal content up to 89%.
Effect of Credible Online Review, Brand Equity Dimension, and Customer Satisfaction Towards Bio Beauty Lab's Repurchase Intention
Authors: Cyntya Carin , Berlianto Margaretha Pink
Published: May 2023

Purpose – This study aimed to analyze the effect of Credible Online Reviews, Brand Equity Dimension, and Customer Satisfaction on the Bio Beauty Lab’s customers’ repurchase intention.
Methodology –This is a quantitative study conducted on 229 Bio Beauty Lab customers living in Jabodetabek determined using non-purposive sampling. The data collected from the respondents through questionnaire distribution were analyzed using PLS-SEM.
Findings – Credible online reviews positively affect brand awareness and perceived value, but do not impact brand personality, organizational associations, and perceived value. Brand awareness, perceived value, brand personality, organizational associations, and perceived quality positively affect customer satisfaction. Additionally, satisfaction affects the Bio Beauty Lab customers' repurchase intention.
Originality – This study provides a newer and deeper understanding of credible online reviews and brand equity by focusing on the importance of customer satisfaction and repurchase intention.
A RESOLUÇÃO DE PROBLEMAS EM SALA DE AULA NA PERSPECTIVA DA LESSON STUDY (PESQUISA DE AULA): O RELATO DE UMA EXPERIÊNCIA
Authors: Regina D'Antonio Verrengia Sandra , Pereira Junior Ademir , Oliveira Santos Guilherme
Published: May 2023

Este artigo, na forma de relato de experiência foi desenvolvido no âmbito do Programa de Residência Pedagógica (PRP) – Subprojeto Matemática da Universidade Estadual de Maringá com o objetivo de possibilitar aos integrantes do PRP uma reflexão a respeito da prática docente pensada desde sua preparação até seu desenvolvimento em sala aula. Para isso, utilizamos os princípios da metodologia Lesson Study (Pesquisa de Aula), aliada a Resolução de Problemas (RP). A partir de um trabalho colaborativo entre a coordenação, os residentes e professores preceptores do PRP, foram realizadas as etapas da Lesson Study (planejamento, execução, análise e retomada de uma aula) envolvendo a metodologia da RP. A aplicação da aula ocorreu em uma turma de 6º ano do Colégio Estadual Adaile Maria Leite (Maringá, PR) contanto com a presença de alguns residentes, do professor preceptor e da professora coordenadora. O trabalho colaborativo, focado no desenvolvimento dos alunos e em sua aprendizagem trouxe contribuições tanto para os futuros docentes que conseguiram ver, na prática, os conceitos estudados durante sua formação, como para os alunos do 6º ano que participaram ativamente do processo de ensino tendo a oportunidade de compreender um novo conceito.
Identifying priority sites for the on-farm conservation of landraces and systematic diversity monitoring through an integrated multi-level hotspot analysis: the case of potatoes in Peru
Authors: Dawson Tamsyn , Juarez Henry , Maxted Nigel , de Haan Stef
Published: May 2023

Introduction

Effective monitoring of the in situ conservation status and change dynamics of landrace populations in their centers of origin ideally requires the identification of sites that are complementary in terms of the richness, uniqueness and coverage of genetic diversity.

Methods

We applied a 4-step approach to identify sites of high potato landrace diversity which will guide the set-up of a network of complementary prospective conservation observatories in Peru, the potato center of origin. A GIS mapping approach was used to determine which combination of sites would provide the most comprehensive and complementary genepool coverage. A landrace inventory was developed from 49 sources, comprising 47,272 landrace records, 97.1% with coordinates, which was used to derive landrace, cultivated species, and cultivar group richness. Data on known indicators of agrobiodiversity, including potato wild relative concurrence, cultivated area, ecogeographic diversity, and ethnolinguistic diversity were included in the spatial overlay analysis, which was used in conjunction with expert opinion data to provide further insight to hotspot selection.

Results

Thirteen hotspots with high, unique, and complementary levels of landrace diversity were identified. We recommend that robust baselines are established, documenting current diversity in these sites using semi-standardized methods and metrics for future tracking.

Discussion

Our results, while being the most robust of their kind to date, were inevitably affected by data gaps, infrastructure and hotspot biases. New documentation efforts should record landrace diversity in uncovered regions, as well as explore complementary mechanisms to track the conservation status of unique endemic landraces that occur in coldspots.
Single-cell RNA sequencing of peripheral blood reveals immune cell dysfunction in premature ovarian insufficiency
Authors: Zhang Caihong , Yu Dong , Mei Yue , Liu Shanrong , Shao Huijing , Sun Qianqian , Lu Qiong , Hu Jingjing , Gu Hang
Published: May 2023

Background

Premature ovarian insufficiency (POI) is one of the most common causes of female infertility and the etiology is highly heterogeneous. Most cases are idiopathic and the pathogenesis remains unclear. Previous studies proved that the immune system plays a crucial role in POI. However, the precise role of immune system remains unclear. This study aimed to analyze the characteristics of peripheral blood mononuclear cells (PBMC) from patients with POI by single-cell RNA sequencing (scRNA-seq) and to explore the potential involvement of immune response in idiopathic POI.

Methods

PBMC was collected from three normal subjects and three patients with POI. PBMC was subjected to scRNA-seq to identify cell clusters and differently expressed genes (DEGs). Enrichment analysis and cell-cell communication analysis were performed to explore the most active biological function in the immune cells of patients with POI.

Results

In total, 22 cell clusters and 10 cell types were identified in the two groups. Compared with normal subjects, the percentage of classical monocytes and NK cells was decreased, the abundance of plasma B cells was increased, and CD4/CD8 ratio was significantly higher in POI. Furthermore, upregulation of IGKC, IFITM1, CD69, JUND and downregulation of LYZ, GNLY, VCAN, and S100A9 were identified, which were enriched in NK cell-mediated cytotoxicity, antigen processing and presentation, and IL-17 signaling pathway. Among them, IGHM and LYZ were respectively the most significantly upregulated and downregulated genes among all cell clusters of POI. The strength of cell-cell communication differed between the healthy subjects and patients with POI, and multiple signaling pathways were assessed. The TNF pathway was found to be unique in POI with classical monocytes being the major target and source of TNF signaling.

Conclusions

Dysfunction of cellular immunity is related to idiopathic POI. Monocytes, NK cells, and B cells, and their enriched differential genes may play a role in the development of idiopathic POI. These findings provide novel mechanistic insight for understanding the pathogenesis of POI.
Prognostic significance of thyroid-stimulating hormone receptor antibodies in moderate-to-severe graves’ orbitopathy
Authors: Park Jungyul , Kim Jaehyun , Kim Sang Soo , Choi Hee-Young
Published: May 2023

Design

Retrospective study

Purpose

The purpose of this retrospective study was to assess the changes in thyroid-stimulating hormone receptor (TSH-R) antibody levels following treatment in patients with moderate-to-severe and active Graves’ orbitopathy (GO) and to investigate the correlation between these antibodies and treatment response.

Methods

The subjects of this study comprised of patients newly diagnosed with moderate-to-severe and active GO within the age range of 19 to 79 years. All participants underwent intravenous methylprednisolone (IVMP) therapy for a duration of 12 weeks. Patients with a clinical activity score (CAS) decrease to or less than 3 and no symptom recurrence for at least 3months after the last dose of IVMP were classified as “Group 1”. Those with a CAS equal to or greater than 4 were classified as “Group 2”. TSH-R antibody levels were measured prior to and following IVMP treatment and treatment response was evaluated after the completion of IVMP therapy. All patients were monitored for a minimum of 6 months post-treatment, with ocular examinations and laboratory tests at the initial visit being included in the analysis.

Results

The medical records of the 96 patients with GO were retrospectively reviewed. Seventy-five patients (78.1%) were response and 21 (21.9%) were non-responsive to IVMP treatment. A higher TSH-R antibody (TRAb) and thyroid-stimulating antibody (TSAb) following treatment were associated with a high risk of no treatment response (P = 0.017; P = 0.047, respectively). TRAb and TSAb levels before treatment were significantly related to TRAb and TSAb levels after treatment (P < 0.001, respectively). The cut-off values for the prediction of poor treatment response of the TRAb and TSAb before and after treatment were 8.305 IU/L, 5.035 IU/L and 449.5%, 361%, respectively (P = 0.027, P =0.001 and P = 0.136, P = 0.004, respectively).

Conclusion

It was observed that elevated levels of TRAb and TSAb prior to IVMP treatment were positively correlated with post-treatment levels of these antibodies. Furthermore, in cases of non-response to IVMP therapy, a diminished decline in both antibodies was observed, and elevated levels of TRAb and TSAb post-treatment were found to be a significant predictor of poor treatment outcome. Measurement of TRAb and TSAb throughout the course of treatment in moderate-to-severe and active cases of GO may offer valuable insights into treatment prognosis and aid in the decision-making process regarding the potential need for increased IVMP dosage or alternative therapeutic strategies.
Identification and analysis of type 2 diabetes-mellitus-associated autophagy-related genes
Authors: Cui Kun , Li Zhizheng
Published: May 2023

Introduction

Autophagy, an innate safeguard mechanism for protecting the organism against harmful agents, is implicated in the survival of pancreatic â cells and the development of type 2 diabetes mellitus (T2DM). Potential autophagy-related genes (ARGs) may serve as potential biomarkers for T2DM treatment.

Methods

The GSE25724 dataset was downloaded from the Gene Expression Omnibus (GEO) database, and ARGs were obtained from the Human Autophagy Database. The differentially expressed autophagy-related genes (DEARGs) were screened at the intersection of ARGs and differentially expressed genes (DEGs) between T2DM and non-diabetic islet samples, which were subjected to functional enrichment analyses. A protein–protein interaction (PPI) network was constructed to identify hub DEARGs. Expressions of top 10 DEARGs were validated in human pancreatic â-cell line NES2Y and rat pancreatic INS-1 cells using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cell viability and insulin secretion were measured after cell transfection with lentiviral vector EIF2AK3 or RB1CC1 into islet cells.

Results

In total, we discovered 1,270 DEGs (266 upregulated and 1,004 downregulated genes) and 30 DEARGs enriched in autophagy- and mitophagy-related pathways. In addition, we identified GAPDH, ITPR1, EIF2AK3, FOXO3, HSPA5, RB1CC1, LAMP2, GABARAPL2, RAB7A, and WIPI1 genes as the hub ARGs. Next, qRT-PCR analysis revealed that expressions of hub DEARGs were consistent with findings from bioinformatics analysis. EIF2AK3, GABARAPL2, HSPA5, LAMP2, and RB1CC1 were both differentially expressed in the two cell types. Overexpression of EIF2AK3 or RB1CC1 promoted cell viability of islet cells and increased the insulin secretion.

Discussion

This study provides potential biomarkers as therapeutic targets for T2DM.
Higher radiation dose on immune cells is associated with radiation-induced lymphopenia and worse prognosis in patients with locally advanced esophageal squamous cell carcinoma
Authors: Qiu Jianjian , Lin Hancui , Ke Dongmei , Yu Yilin , Xu Jiaying , Qiu Hejin , Zheng Qunhao , Li Hui , Zheng Hongying , Liu Lingyun , Wang Zhiping , Yao Qiwei , Li Jiancheng
Published: May 2023

Background

To explore the effective dose to immune cells (EDIC) for better prognosis while avoiding radiation-induced lymphopenia (RIL) in patients with locally advanced esophageal squamous cell carcinoma (ESCC).

Materials and methods

Overall, 381 patients with locally advanced ESCC receiving definitive radiotherapy with or without chemotherapy (dRT ± CT) between 2014 and 2020 were included in this study. The EDIC model was calculated by radiation fraction number and mean doses to the heart, lung, and integral body. The correlation between EDIC and clinical outcomes was analyzed using Cox proportional hazards regression, and risk factors for RIL were determined by logistic regression analysis.

Results

The median EDIC was 4.38 Gy. Multivariate analysis revealed that low-EDIC significantly improved the OS of patients when compared with high-EDIC (HR = 1.614, P = 0.003) and PFS (HR = 1.401, P = 0.022). Moreover, high-EDIC was associated with a higher incidence of grade 4 RIL (OR = 2.053, P = 0.007) than low-EDIC. In addition, we identified body mass index (BMI), tumor thickness, and nodal stage as independent prognostic factors of OS and PFS, while BMI (OR = 0.576, P = 0.046) and weight loss (OR = 2.214, P = 0.005) as independent risk factors of grade 4 RIL. In subgroup analyses, the good group had better clinical outcomes than the remaining two groups (P< 0.001).

Conclusion

This study demonstrated that EDIC significantly correlates with poor clinical outcomes and severe RIL. Optimizing treatment plans to decrease the radiation doses to immune cells is critical for improving the outcomes.