bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of life and lung function after pleurectomy/decortication for malignant pleural mesothelioma
Authors: Nakamichi Toru , Hashimoto Masaki , Nakamura Akifumi , Kuroda Ayumi , Tanaka Takashi , Takeuchi Jiro , Matsumoto Seiji , Morimoto Takeshi , Kondo Nobuyuki , Domen Kazuhisa , Hasegawa Seiki
Published: April 2021

OBJECTIVES

Impact of pleurectomy/decortication (P/D) on quality of life (QOL) is not widely reported. We investigated QOL and lung function after P/D.

METHODS

A single-centre, retrospective cohort study was performed among patients who underwent P/D for malignant mesothelioma between June 2014 and June 2018 at Hyogo College of Medicine. Data at 4 points before and 3, 6 and 12 months on QOL and lung function were evaluated with the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and pulmonary function tests.

RESULTS

Forty-five out of 65 patients completed SF-36. Physical function and role physical decreased from 78 to 65 and 69 to 41 and did not recover. Body pain decreased from 74 to 52. It increased to 62 at 12 months but was lower than before. General health perceptions, vitality and social function decreased from 56 to 49, 50 to 47 and 63 to 50, respectively, but returned to baseline. Role emotional decreased from 75 to 54, then once increased to 63, but decreased again to 58. Mental health tended to improve from 58 to 70. Thirty-eight patients out of 45 completed pulmonary function tests. Forced vital capacity and forced expiratory volume in 1 s decreased from 98% to 61% and 93% to 67% and did not increase. Right-sided surgery or complications was the risk factors of poor lung function but no significant risk factors in QOL.

CONCLUSIONS

This study suggests that P/D had an impact on QOL. Despite the lack of recovery in lung function QOL in mental aspects tended to improve, suggesting that pulmonary function tests alone are limited in assessing QOL.
Validation of QuEChERS Method Coupled with LC-MS/MS for Determination of Thiamethoxam and its Metabolites in Wheat and Soil
Authors: Rasool Rozy , Kang Balpreet Kaur , Mandal Kousik
Published: April 2021

Background

Thiamethoxam, a neonicotinoid insecticide, has been widely accepted for the control of sucking and certain chewing pests. Through different routes, i.e., wind drift, leaching, and surface runoff, it can reach non-target areas, which include humans as well. Therefore the fate of thiamethoxam in food grains and soil is of prime importance, entailing a need for pesticide use to be subject to steady observation.

Objective

The review aimed to validate the Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method for the detection of thiamethoxam and its metabolites in wheat leaves, grain, straw, and soil using liquid chromatography–tandem mass spectrometry (LC-MS/MS).

Method

The QuEChERS method allows sample extraction by acetonitrile followed by cleanup with a primary secondary amine sorbent, magnesium sulphate, and graphitized carbon black. The method was validated in terms of selectivity, linearity, LOD, LOQ, matrix match, accuracy, and precision. The estimation of residues was done by LC-MS/MS.

Results

The recovery of thiamethoxam and its metabolites in wheat and soil samples was in the range of 81.22–98.14%. The LOQ for thiamethoxam and its metabolites was 0.01 mg/kg. The matrix effect values were in the acceptable range of –20 to +20%.

Conclusions

The method allows a simple and fast extraction of thiamethoxam and its metabolites from wheat leaves, grain, straw, and soil. It could be helpful in the evaluation of regulatory and food safety decisions regarding the use of neonicotinoids.

Highlights

The method was validated according to the European Commission SANTE/12682/2019 guidelines. An accurate, simple, and sensitive analytical method was validated for thiamethoxam and its metabolites.
A comparison of the release of phosphorus by a phytase enzyme in pigs fed diets deficient or adequate in phosphorus content
Authors: Olsen Kristin M , Gould Stacie A , Patience John F
Published: April 2021

Previous research indicated that phytase may release less phosphorus (P) from phytate when it is evaluated using diets with P levels above requirement as compared with diets below requirement. The objectives of this experiment were to further test the hypothesis that the P release values determined for phytase are higher when pigs are fed diets that are deficient (DE) in P compared with when they are fed diets that are adequate (AD) in P, and that phytase will increase the digestibility of dry matter (DM), gross energy (GE), nitrogen (N), and calcium (Ca) independent of dietary P status. Twenty-four barrows (body weight: 23.2 ± 1.8 kg) were randomly assigned to one of eight dietary treatments and housed in individual pens for 21 d and then moved to metabolism crates for 9 d, with the collection of urine and feces occurring on the final 5 d. A basal corn–soybean meal diet (P-AD) was formulated at 0.36% standardized total tract digestible (STTD) P and total calcium:STTD P (Ca:STTD P) of 2:1. A P-DE diet was also formulated to maintain a constant Ca:STTD P of 2:1 in both basal diets. Phytase was added to AD and DE diets at 350, 600, 1,000 phytase units (FYT)/kg. Pig was the experimental unit; diet (P-AD or P-DE), phytase level, and replicate were fixed effects. Orthogonal polynomial contrasts were used to test linear and quadratic effects of phytase within P-AD and P-DE diets. Phytase improved apparent total tract digestibility (ATTD) and STTD of P in both P-AD (linear P < 0.001) and P-DE diets (quadratic P < 0.001). Estimates for STTD P release were 0.07%, 0.09%, and 0.09% for 350, 600, and 1,000 phytase units (FYT)/kg in P-DE diets, and 0.02%, 0.03%, and 0.05% in P-AD diets, respectively. In P-DE diets, phytase improved absorption and retention of P and increased urinary excretion of P (quadratic P < 0.001). In P-AD diets, phytase improved absorption of P (linear P = 0.066), tended to improve retention (linear P = 0.066), and increased urinary excretion of P (quadratic P = 0.021). Phytase improved ATTD of Ca in P-DE diets (quadratic P = 0.002) but not in P-AD diets (P > 0.1). In conclusion, the release of P by phytase is lower in diets that are AD in P than those which are DE. Phytase increased the availability of Ca only in the diets DE in P. Finally, phytase increased the ATTD of DM and tended to increase the ATTD of energy, independent of dietary P status.
Behavior, blood stress indicators, skin lesions, and meat quality in pigs transported to slaughter at different loading densities
Authors: Urrea Valentina Montoya , Bridi Ana Maria , Ceballos Maria Camila , Paranhos da Costa Mateus J R , Faucitano Luigi
Published: April 2021

A total of 1,936 pigs were transported through 8 trips (8.4 ± 0.5 hr) from 2 grow-to-finish farms to a commercial slaughter plant, all located in Southern Brazil. On each trip, a sub-sample of each load (36 barrows/load, weighing 118.9 ± 9.8 kg) was randomly allocated into one of the following loading densities during transport: 200 kg/m2 (D200), 235 kg/m2 (D235), and 270 kg/m2 (D270). Behavioral recordings of postures and activities were made during transportation and lairage using video-cameras. At slaughter, blood samples were collected to assess the concentrations of creatine kinase (CK) and lactate. Carcass weights and skin lesion scores were assessed on-line, and meat quality was evaluated in the longissimus thoracis (LT) muscle by assessing pH, color, and drip loss. During transportation, the proportion of animals lying down was higher (P < 0.05) in D200 and D235 groups compared with D270. The proportion of sitting animals during transportation was higher (P < 0.01) in D270 compared with D200. In lairage, D200 and D235 pigs stood more compared with D270 (P = 0.01), while the proportion of lying pigs was higher (P = 0.02) for D270 pigs compared with D200 and D235. The frequency of drinking bouts in lairage was higher (P < 0.05) for D200 group compared with D235 and D270. The levels of CK were lower (P < 0.05) in D200 pigs transported compared with D270. Lesion scores tended to be higher (P = 0.06) in D270 carcasses compared with D200 and D235. A tendency for lower (P = 0.10) pH1 values in the LT muscle of D270 pigs compared with D200 pigs was also found. Based on the results of this study, the application of lower loading densities (≤235 kg/m2) in the truck allows pigs to have sufficient space to rest, travel more comfortably and arrive less fatigued at the slaughter plant.
Effects of Trap, and Ethanol Lure Type and Age on Attraction of Ambrosia Beetles (Coleoptera: Curculionidae)
Authors: Monterrosa Alejandra , Acebes Angelita L , Blaauw Brett , Joseph Shimat V
Published: April 2021

Ambrosia beetles (Xylosandrus spp.) are pests of woody ornamental nurseries and tree nut orchards. Growers use ethanol-infused bolts and ethanol-mediated bottle traps for monitoring ambrosia beetles in the spring. To refine these monitoring tools, we investigated the 1) sensitivity of the commercially available ethanol pouches placed on bolts compared with that of ethanol-infused bolts for ambrosia beetle attacks; and 2) the effect of aging of ethanol pouches on ambrosia beetle captures in bottle traps. Experiments were conducted in ornamental nurseries and pecan orchards in 2019 and 2020. For objective 1, the treatments included a bolt infused with locally purchased ethanol, an ethanol pouch attached to a bolt, and a control (bolt without ethanol). For objective 2, ethanol pouches were initially field-aged for 0, 1, 2, 3, and 4 wk and ambrosia beetle captures were documented weekly for 4 wk. Ethanol pouches older than 5 wk were replaced with fresh pouches at the pecan sites while ethanol pouches at nursery sites were aged up to 8 wk. The ethanol-pouch comparison study showed that the number of ambrosia beetle attacks was significantly greater on ethanol-infused bolt traps than with the ethanol pouches on bolts at the nursery and pecan sites in both years. The age of the ethanol pouches did not affect captures of Xylosandrus crassiusculus (Motschulsky) and X. germanus (Blandford) in bottle traps within 8 wk of deployment. Results provide practical implications into the sensitivity of the different ethanol lure types in association with bolt traps and the longevity of the ethanol pouches for grower use.
Electoral Systems and Inequalities in Government Interventions
Authors: Genicot Garance , Bouton Laurent , Castanheira Micael
Published: April 2021

This paper studies the political determinants of inequalities in government interventions under majoritarian (MAJ) and proportional representation (PR) systems. We propose a probabilistic voting model of electoral competition with highly targetable government interventions and heterogeneous localities. We uncover a novel relative electoral sensitivity effect that affects government interventions only under MAJ systems. This effect tends to reduce inequality in government interventions under MAJ systems when districts are composed of sufficiently homogeneous localities. This effect goes against the conventional wisdom that MAJ systems are necessarily more conducive to inequality than PR systems. We illustrate the empirical relevance of our results with numerical simulations on possible reforms of the US Electoral College.
Lithospheric structure beneath southern Iberia and northern Morocco constrained by 3D Kirchhoff-approximate GRT imaging
Authors: Li Qinci , Palomeras Imma , Meng Xiaohong
Published: April 2021

The slab beneath the Alboran Sea is a consequence of the collision between two continents (Europe and Africa), which was initiated along the northeastern Spanish coast, experienced slab rollback and migrated to the area adjacent to the two continents. The tectonic background in this area includes episodes of collisions with adjacent continents as well as extension of those basins in the western Mediterranean. Here, we present three-dimensional (3D) Kirchhoff-approximate generalized Radon transform (GRT) images to further constrain the lithospheric structures previously identified by other researchers. The GRT images were calculated from the same P-to-S (Pds or Ps) teleseismic receiver functions (RFs) as the previous common conversion point (CCP) stacking, but the GRT data provide figures with greater resolution than the Pds RFs CCP results. This study indicates that the Alboran Slab may have completely detached from the crustal base under the western Betics Mountains and that a larger range of lithospheric ‘peeling off’ developed beneath the western part of the Betics Mountains than some previous results have claimed. The observed thin lithosphere under the Middle Atlas (MA) and eastern High Atlas (HA) may have a geodynamic relationship with lithospheric delamination under the eastern part of the Rif Mountains, which has also led to the thin lithosphere under the eastern Rif. According to the thick lithosphere under the western HA, the shallow LAB under the MA and eastern HA may have no heat-flow connection with the Canary mantle plume, as stated in several previous studies.
A Comparison of Questing Substrates and Environmental Factors That Influence NymphalIxodes pacificus(Acari: Ixodidae) Abundance and Seasonality in the Sierra Nevada Foothills of California
Authors: Hacker Gregory M , Jackson Bryan T , Niemela Michael , Andrews Elizabeth S , Danforth Mary E , Pakingan Mary Joyce , Novak Mark G
Published: April 2021

In California, the western blacklegged tick, Ixodes pacificus Cooley and Kohls, is the principal vector of the Borrelia burgdorferi sensu lato (sl) complex (Spirochaetales: Spirochaetaceae, Johnson et al.), which includes the causative agent of Lyme disease (B. burgdorferi sensu stricto). Ixodes pacificus nymphs were sampled from 2015 to 2017 at one Sierra Nevada foothill site to evaluate our efficiency in collecting this life stage, characterize nymphal seasonality, and identify environmental factors affecting their abundance and infection with B. burgdorferi sl. To assess sampling success, we compared the density and prevalence of I. pacificus nymphs flagged from four questing substrates (logs, rocks, tree trunks, leaf litter). Habitat characteristics (e.g., canopy cover, tree species) were recorded for each sample, and temperature and relative humidity were measured hourly at one location. Generalized linear mixed models were used to assess environmental factors associated with I. pacificus abundance and B. burgdorferi sl infection. In total, 2,033 substrates were sampled, resulting in the collection of 742 I. pacificus nymphs. Seasonal abundance of nymphs was bimodal with peak activity occurring from late March through April and a secondary peak in June. Substrate type, collection year, month, and canopy cover were all significant predictors of nymphal density and prevalence. Logs, rocks, and tree trunks had significantly greater nymphal densities and prevalences than leaf litter. Cumulative annual vapor pressure deficit was the only significant climatic predictor of overall nymphal I. pacificus density and prevalence. No associations were observed between the presence of B. burgdorferi sl in nymphs and environmental variables.
Molecular Analysis of Targeted Insecticide Resistance Gene Mutations in Field-Caught Mosquitos of Medical Importance From Saudi Arabia
Authors: Fang Yuan , Tambo Ernest , Xue Jing-Bo , Zhang Yi , Zhou Xiao-Nong , Khater Emad I M
Published: April 2021

Gene mutations on target sites can be a valuable indicator of the status of insecticide resistance. Jeddah, a global commercial and major port-of-entry city, is bearing the brunt of dengue disease burden in Saudi Arabia. In the current study, six genotypes of three codon combinations (989, 1016, and 1534) were observed on voltage-gated sodium channel (VGSC) gene in Jeddah’s Aedes aegypti population, with PGF/PGC as the dominant one. Two types of introns between exon 20 and 21 on VGSC have been identified for the first time in Ae. aegypti in Saudi Arabia. Statistical and phylogenetic analyses showed that the intron type was significantly associated with the 1016 allele and may reflect the history of insecticide treatment in different continents. In addition, fixation of the L1014F allele on VGSC and G119S on acetylcholinesterase 1 gene was detected in local Culex quinquefasciatus populations, with frequencies of 95.24 and 100%, respectively. To the best of our knowledge, this is the first report of resistant-associated mutations in field-caught Cx. quinquefasciatus in Saudi Arabia. The high prevalence of insecticide resistance gene mutations in local primary mosquito vector species highlights the urgent need to carry out comprehensive insecticide resistance surveillance in Saudi Arabia.
From Refugee to Resident in the Digital Age: Refugees’ Strategies for Navigating in and Negotiating Beyond Uncertainty During Reception and Settlement in The Netherlands
Authors: Miellet Sara
Published: April 2021

This article examines digital tactics adopted by refugees and asylum-seekers in the Netherlands to cope with spatial and temporal dimensions of uncertainty during different stages of their arrival. It draws attention to how particular modes of Dutch asylum and refugee reception governance, such as dispersal and housing allocation policies, give rise to spatial and temporal uncertainties. Based on participant observations and 23 qualitative interviews with recognized refugees in the cities of Utrecht and Houten, the article offers insight into how refugees used digital tactics and mobile connectivity to ‘navigate in’ and ‘negotiate beyond uncertainty’. The article seeks to contribute to this conceptual differentiation between ‘navigating in’ and ‘negotiating beyond’ uncertainty, engaging with work on migrant agency that acknowledges their acts of resilience, reworking and resistance. Lastly, I discuss this understanding of digital tactics to cope with uncertainty in light of recent critiques in forced migration studies of essentialist understandings of uncertainty and utilitarian narratives of digitally connected migrants.
Chloroplast thylakoid ascorbate peroxidase PtotAPX plays a key role in chloroplast development by decreasing hydrogen peroxide in Populus tomentosa
Authors: Li Conghui , Liu Yadi , Liu Xiatong , Mai Keith Ka Ki , Li Jiaxin , Guo Xiaorui , Zhang Chong , Li Hui , Kang Byung-Ho , Hwang Inhwan , Lu Hai
Published: April 2021

Chloroplast development is a complex process that is critical to the growth and development of plants. However, the detailed mechanism of chloroplast development in woody plants remains unclear. In this study, we showed that chloroplasts with elaborate thylakoids could develop from proplastids in the cells of calli derived from leaf tissues of Populus tomentosa upon exposure to light. Chloroplast development was confirmed at the molecular and cellular levels. Transcriptome analysis revealed that genes related to photoreceptors and photosynthesis were significantly up-regulated during chloroplast development in a time-dependent manner. In light-induced chloroplast development, a key process was the removal of hydrogen peroxide, in which thylakoid-localized PtotAPX played a major role; light-induced chloroplast development was enhanced in PtotAPX-overexpressing transgenic P. tomentosa callus with lower levels of hydrogen peroxide, but was suppressed in PtotAPX antisense transgenic callus with higher levels of hydrogen peroxide. Moreover, the suppression of light-induced chloroplast development in PtotAPX antisense transgenic callus was relieved by the exogenous reactive oxygen species scavenging agent N,N′-dimethylthiourea (DMTU). Based on these results, we propose that PtotAPX-mediated removal of reactive oxygen species plays a key role in chloroplast development from proplastids upon exposure to light in P. tomentosa.
Algorithmic properties of first-order modal logics of linear Kripke frames in restricted languages
Authors: Rybakov Mikhail , Shkatov Dmitry
Published: April 2021

We study the algorithmic properties of first-order monomodal logics of frames $\langle {\textrm{I}\!\textrm{N}}, \leqslant \rangle $, $\langle {\textrm{I}\!\textrm{N}}, < \rangle $, $\langle \mathbb {Q}, \leqslant \rangle $, $\langle \mathbb {Q}, < \rangle $, $\langle {\textrm{I}\!\textrm{R}}, \leqslant \rangle $, $\langle {\textrm{I}\!\textrm{R}}, < \rangle $, as well as some related logics, in languages with restrictions on the number of individual variables as well as the number and arity of predicate letters. We show that the logics of frames based on $ {\textrm{I}\!\textrm{N}}$ are $\varPi ^1_1$-hard—thus, not recursively enumerable—in languages with two individual variables, one monadic predicate letter and one proposition letter. We also show that the logics of frames based on $\mathbb {Q}$ and ${\textrm{I}\!\textrm{R}}$ are $\varSigma ^0_1$-hard in languages with the same restrictions. Similar results are obtained for a number of related logics.
Biomarkers Predicting Antidepressant Treatment Response
Authors: Gadad Bharathi S. , Jha Manish K. , Trivedi Madhukar H.
Published: April 2021

In clinical practice, patients do not always experience symptomatic remission or treatment response, even after trying various types of antidepressant medications. To improve outcomes and reduce attrition and nonadherence, there is a great need for personalized treatment of major depression. Hence, recent research efforts have focused on the identification of biological markers (or biomarkers) that can predict whether an individual patient will respond to the commonly used antidepressants. In this chapter, we review the biomarkers associated with antidepressant treatment response with particular attention to genetic, proteomic, metabolomic, transcriptomic, epigenetic biological, and biochemical markers. Although the “omics” approach holds great promise for the future, challenges and roadblocks for future research will need to be addressed.
Bipolar Disorder
Authors: da Costa Sabrina C. , Sanches Marsal , Soares Jair C.
Published: April 2021

Bipolar disorder (BD) is a complex and severe mental illness, associated with substantial morbidity and increased mortality. Depressive symptoms frequently prevail in the course of illness, and significant morbidity arises from acute affective episodes and subacute states. Phenotypically, unipolar and bipolar depression seem to share several clinical features, which leads to an average delay of 10 years between initial symptoms and the diagnosis of BD. Multidimensional approaches have been proposed to better predict BD in at-risk populations; however, the differential diagnosis between these two entities remains a clinical challenge. Similarly to other chronic conditions, it has been proposed that BD is also a progressive disorder, where multiple affective episodes may result in structural, functional, and neurobiological brain abnormalities that accelerate illness progression, with subsequent treatment resistance and reduction in interepisode interval. Therefore, strategies to improve diagnosis accuracy are pivotal to improve clinical outcomes and long-term prognosis in the course of BD. In this chapter, we aim to provide a critical overview of psychopathological, sociodemographic, and neurobiological features to help clinicians properly distinguish unipolar and bipolar depression. Pathological and therapeutic implications of misdiagnosing BD are briefly discussed.
Primer on Depression
Authors: Hughes Jennifer L.
Published: April 2021

Suicide is a public health problem worldwide and one of the leading causes of death in the United States. Suicidal behavior is also a major public health concern, with more than 1 million people per year attempting suicide in the United States. Suicide is a complex phenomenon, occurring because of a convergence of genetic, environmental, psychological, social, cultural, and systemic risk and protective factors. As such, suicide prevention efforts must include interventions across the spectrum of society, from healthcare to school to public health and community efforts. This chapter reviews the risk and protective factors related to suicide; research findings about the mechanisms and functions of suicidal behavior; principles of crisis intervention; treatments to address suicidal behavior; an overview of suicide risk and treatment in special populations, including youth, geriatric, and sexual and gender minority populations; and an overview of postvention efforts.
General Medical Conditions
Authors: Pilkinton Patricia , Davis Lori L.
Published: April 2021

The differential diagnosis of major depressive disorder should include a comprehensive evaluation of past and current medical disorders. Comorbid medical conditions and/or their treatments can be a root cause or a contributor to the depressive episode. Conversely, symptoms of depression can exacerbate or mimic a medical condition. This chapter reviews cardiovascular, pulmonary, endocrine, gastrointestinal, hepatic, immunologic, dermatologic, and neurologic medical conditions that can mimic or exacerbate depression, as well as cancer and pain. Suggestions for treatment and management of depression are provided for each major organ system, as well as medications that have possible depression as a side effect. Untreated depression in patients with general medical conditions is a modifiable risk factor for poor medical outcomes.
Primer on Depression
Authors: Salloum Naji C. , Papakostas George I.
Published: April 2021

Several first-line antidepressant therapies are currently available for the treatment of major depressive disorder (MDD), but in most patients depression fail to remits after an initial medication trial. In this chapter, we explore the evidence for different augmentation strategies used to enhance the response from an initial antidepressant monotherapy. Atypical antipsychotics, several of which are now approved by the US Food and Drug Administration as adjunctive agents for the treatment of MDD, and lithium are among the most evidence-based augmentation pharmacotherapies. Other therapies, such as bupropion, mirtazapine, triiodothyronine, nutraceuticals, and psychotherapy, are also commonly used. Additionally, several investigational drugs, including ketamine, esketamine, and ALKS 5461, with novel mechanisms of action, show promise.
Management of Side Effects of Antidepressant Medications
Authors: Mago Rajnish
Published: April 2021

Side effects of antidepressants are common, distressing, and impairing. They have a substantial effect on nonadherence to antidepressants, which is very common. Greater attention to learning about various strategies for preventing, reducing, and managing side effects may have a significant effect in improving the outcomes of treatment with antidepressants. Attention needs to be paid to both common, “nuisance” side effects and the uncommon or rare “medically serious” side effects. This chapter provides examples of both categories. While nuisance side effects may seem unimportant, in fact, they have a considerable impact on nonadherence. On the other hand, while medically serious side effects may be seen as uncommon or even rare, they can lead to serious consequences. In particular, clinicians who often treat patients who are at high risk of such medically serious side effects need to be thoroughly familiar with them. Clinicians who prescribe antidepressant medications are urged to have a menu of options for the management of side effects, ranging from simple, benign interventions to more active interventions that may carry risks of their own. The latter are often needed in situations where continuing that particular antidepressant, or type of antidepressant, is essential and stopping or changing it is not a reasonable option. In such situations, risk/benefit considerations require that the side effect be actively treated to allow the patient to stay on the medication. This chapter provides many examples of both simple and more active interventions for a variety of potential side effects of antidepressants.
Psychodynamic and Supportive Psychotherapy
Authors: Hellerstein David J. , Kane Alexander
Published: April 2021

Patients with mood disorders often can benefit from psychotherapy, whether as a primary treatment for depression or as an adjunct to medications or other biological treatments. Today, therapeutic approaches such as cognitive–behavioral therapy and interpersonal therapy are commonly thought of as first-line evidence-based treatments of depression, yet there is also evidence that psychodynamic psychotherapy (PDT) and supportive psychotherapy (SPT) can be effective treatments of depression. Both PDT and SPT are commonly used in clinical practice, by a wide range of clinicians and in many different settings. This chapter describes the theoretical background of each of these therapies, therapeutic techniques, how they can be adapted for treatment of depression, and patient populations for which they may be indicated.
Exercise as a Treatment for Depression
Authors: Rethorst Chad D.
Published: April 2021

Beginning with epidemiological evidence and moving to randomized controlled trials, researchers have established evidence supporting the effectiveness of exercise in the treatment of depression. This chapter will provide an overview of the benefits of exercise for patients with depression, discuss the challenges clinicians face in using exercise as a treatment in clinical practice, and provide practical advice on exercise prescription. The chapter concludes with a discussion of areas of need for future research, focusing on three areas: identifying strategies to ensure patient adherence with exercise prescriptions, identifying predictors of treatment response that will facilitate a personalized medicine approach to exercise prescription, and the use of exercise as a complementary agent with other depression treatments.
Depression Following Mild Traumatic Brain Injury
Authors: Cullum C. Munro , Munro Catherine
Published: April 2021

Interest in concussion and traumatic brain injury (TBI) has increased to an all-time high due to recent media attention and public awareness. Mild TBI (mTBI), or concussion, is the most common, accounting for roughly 75% to 90% of all TBIs. Although symptoms vary, typical neurobehavioral domains affected in TBI include physical, cognitive, sleep, and emotional. Whereas the vast majority of people at all ages recover well from mTBI, risk factors and mechanisms for prolonged recovery and so-called post-concussion syndrome remain poorly understood. Nevertheless, detection and treatment of symptoms are important in order to facilitate recovery, as psychological factors may complicate or exacerbate the clinical picture. Post-mTBI depressive symptoms have multifactorial determinants, reflecting a complex neurobiopsychosocial condition.
Primer on Depression
Authors: Kinney Robert S. , Pop Radu
Published: April 2021

Depression is a commonly occurring illness in the general population. Existing systems for identifying and treating depression vary greatly, and the adoption of a universal, standardized method of addressing the disorder within primary care is lacking. New guidelines and recommendations by accrediting bodies have resulted in the development of some initiatives and the increased recognition of depression, yet treatments continue to rely on referrals to specialty psychiatric care providers. Given that primary care may be the only point of health care access for many individuals, this serves as an opportune setting to initiate treatment at the time that depression screening is completed. With adequate support, guidance, and a systemic approach (i.e., measurement-based care), primary care providers can be as effective as psychiatric specialty care in treating depression. This chapter providers evidence for this approach, along with direct recommendations to primary care providers.
Infrared spectroscopy of clathrate hydrates for planetary science: the ethylene case
Authors: Dartois Emmanuel
Published: April 2021

Hydrocarbons are observed in the gas or solid phases of Solar system objects, including comets, Trans-Neptunian Objects, planets, and their moons. In the presence of water ice in these environments, hydrocarbons-bearing clathrate hydrates could form. In clathrate hydrates, guest molecules are trapped in crystalline water cages of different sizes, a phase used in models of planetary (sub-)surfaces or icy bodies such as comets. The phases in presence, the potential estimate of abundances of hydrocarbon species, and the spectroscopic behaviour of hydrocarbon species in the different phases must be recorded to provide reference spectra for the comparison with remote observations. We show in this study the specific encaged ethylene signatures, with bands similar in position, but shifted from the pure ethylene ice spectrum. They show a marked temperature dependence both in position and width. Some vibrational modes are activated in the infrared by interaction with the water ice cages.
Measurement on the cosmic curvature using the Gaussian process method
Authors: Yang Yingjie , Gong Yungui
Published: April 2021

Inflation predicts that the Universe is spatially flat. The Planck 2018 measurements of the cosmic microwave background anisotropy favour a spatially closed universe at more than 2σ confidence level. We use model-independent methods to study the issue of cosmic curvature. The method reconstructs the Hubble parameter H(z) from cosmic chronometers data with the Gaussian process method. The distance modulus is then calculated with the reconstructed function H(z) and fitted by Type Ia supernovae data. Combining the cosmic chronometers and Type Ia supernovae data, we obtain Ωk0h2 = 0.102 ± 0.066 that is consistent with a spatially flat universe at the 2σ confidence level. By adding the redshift-space distortions data to the Type Ia supernovae data with a proposed novel model-independent method, we obtain $\Omega _{k0}h^2=0.117^{+0.058}_{-0.045}$ and no deviation from Λ cold dark matter (ΛCDM) model is found.
Optimizing serendipitous detections of kilonovae: cadence and filter selection
Authors: Almualla Mouza , Anand Shreya , Coughlin Michael W , Dietrich Tim , Guessoum Nidhal , Sagués Carracedo Ana , Ahumada Tomás , Andreoni Igor , Antier Sarah , Bellm Eric C , Bulla Mattia , Singer Leo P
Published: April 2021

The rise of multimessenger astronomy has brought with it the need to exploit all available data streams and learn more about the astrophysical objects that fall within its breadth. One possible avenue is the search for serendipitous optical/near-infrared counterparts of gamma-ray bursts (GRBs) and gravitational-wave (GW) signals, known as kilonovae. With surveys such as the Zwicky Transient Facility (ZTF), which observes the sky with a cadence of ∼3 d, the existing counterpart locations are likely to be observed; however, due to the significant amount of sky to explore, it is difficult to search for these fast-evolving candidates. Thus, it is beneficial to optimize the survey cadence for realtime kilonova identification and enable further photometric and spectroscopic observations. We explore how the cadence of wide field-of-view surveys like ZTF can be improved to facilitate such identifications. We show that with improved observational choices, e.g. the adoption of three epochs per night on a ∼ nightly basis, and the prioritization of redder photometric bands, detection efficiencies improve by about a factor of two relative to the nominal cadence. We also provide realistic hypothetical constraints on the kilonova rate as a form of comparison between strategies, assuming that no kilonovae are detected throughout the long-term execution of the respective observing plan. These results demonstrate how an optimal use of ZTF increases the likelihood of kilonova discovery independent of GWs or GRBs, thereby allowing for a sensitive search with less interruption of its nominal cadence through Target of Opportunity programs.
J2229+2725: an extremely low metallicity dwarf compact star-forming galaxy with an exceptionally high [O iii]λ5007/[O ii]λ3727 flux ratio of 53
Authors: Izotov Y I , Thuan T X , Guseva N G
Published: April 2021

Using the Large Binocular Telescope (LBT)/Multi-Object Dual Spectrograph (MODS), we have obtained optical spectroscopy of one of the most metal-poor dwarf star-forming galaxies (SFGs) in the local Universe, J2229+2725. This galaxy with a redshift z = 0.0762 was selected from the Data Release 16 of the Sloan Digital Sky Survey (SDSS). Its properties derived from the LBT observations are most extreme among SFGs in several ways. Its oxygen abundance 12 + logO/H = 7.085 ± 0.031 is among the lowest ever observed for an SFG. With its very low metallicity, an absolute magnitude Mg = −16.39 mag, a low stellar mass M⋆ = 9.1 × 106 M⊙, and a very low mass-to-light ratio M⋆/Lg ∼ 0.0166 (in solar units), J2229+2725 deviates strongly from the luminosity–metallicity relation defined by the bulk of the SFGs in the SDSS. J2229+2725 has a very high specific star formation rate sSFR ∼ 75 Gyr−1, indicating very active ongoing star formation. Three other features of J2229+2725 are most striking, being the most extreme among lowest metallicity SFGs: (1) a ratio O32 = I([O iii]λ5007)/I([O ii]λ3727) ∼ 53, (2) an equivalent width of the H β emission line EW(H β) of 577 Å, and (3) an electron number density of ∼1000 cm−3. These properties imply that the starburst in J2229+2725 is very young. Using the extremely high O32 in J2229+2725, we have improved the strong-line calibration for the determination of oxygen abundances in the most metal-deficient galaxies, in the range 12 + logO/H $\lesssim$ 7.3.
Resolving star-forming clumps in a z ∼ 2 lensed galaxy: a pixelated Bayesian approach
Authors: Sharma Soniya , Richard Johan , Yuan Tiantian , Patrício Vera , Kewley Lisa , Rigby Jane R , Gupta Anshu , Leethochawalit Nicha
Published: April 2021

We present a pixelized source reconstruction method applied on integral field spectroscopic observations of gravitationally lensed galaxies. We demonstrate the effectiveness of this method in a case study on the clumpy morphology of a z ∼ 2 lensed galaxy behind a group-scale lens. We use a Bayesian forward source modelling approach to reconstruct the surface brightness distribution of the source galaxy on a uniformly pixelized grid while accounting for the image point spread function. The pixelated approach is sensitive to clump sizes down to 100 pc and resolves smaller clump sizes with an improvement in the signal-to-noise ratio by almost a factor of 10 compared with more traditional ray-tracing approaches.
Zinc stable isotopes in urine as diagnostic for cancer of secretory organs
Authors: Schilling Kathrin , Moore Rebekah E T , Sullivan Kaj V , Capper Miles S , Rehkämper Mark , Goddard Kate , Ion Charlotte , Coombes R Charles , Vesty-Edwards Lois , Lamb Alastair D , Halliday Alex N , Larner Fiona
Published: April 2021

Breast, prostate, and pancreatic cancers alter the zinc (Zn) metabolism. Combined analyses of urinary Zn concentrations [Zn] and Zn stable isotope compositions (δ66Zn) may provide a non-invasive approach for tracing malignancy-induced Zn dyshomeostasis. In this study, we measured [Zn] and δ66Zn in urine from prostate (n = 22), breast (n = 16), and from women with benign breast disease (n = 14) and compared those with age-matched healthy controls (22–49 years or 50+ years) and published data for pancreatic cancer (n = 17). Our results show that cancer-induced changes are reflected in higher urinary [Zn] and lower urinary δ66Zn for pancreatic and prostate cancer and benign breast disease when compared with healthy controls. For prostate cancer, the progression of low [Zn] and high δ66Zn for patients of low-risk disease toward high [Zn] and low δ66Zn for the higher risk patients demonstrates that [Zn] and δ66Zn in urine could serve as a reliable prognostic tool. Urinary excretion of isotopically light Zn by patients with prostatic and pancreatic cancer is probably the result of increased reactive oxygen species in cancerous cells, which limits the scavenging of hydroxyl radicals and thus facilitates the oxidation of metalloproteins with sulfur-rich ligands. Urine from breast cancer patients shows undistinguishable δ66Zn to healthy controls, implying that the expression of metalloproteins with sulfur-rich ligands is stronger in breast cancer tissues. In conclusion, urinary δ66Zn may provide a non-invasive diagnostic tool for pancreatic cancer and support disease prognosis for prostate cancer. These findings should translate to comprehensive transverse and longitudinal cohort studies in future.
NSMF promotes the replication stress-induced DNA damage response for genome maintenance
Authors: Ju Min Kyung , Shin Kyeong Jin , Lee Joo Rak , Khim Keon Woo , A. Lee Eun , Ra Jae Sun , Kim Byung-Gyu , Jo Han-seul , Yoon Jong Hyuk , Kim Tae Moon , Myung Kyungjae , Choi Jang Hyun , Kim Hongtae , Chae Young Chan
Published: April 2021

Proper activation of DNA repair pathways in response to DNA replication stress is critical for maintaining genomic integrity. Due to the complex nature of the replication fork (RF), problems at the RF require multiple proteins, some of which remain unidentified, for resolution. In this study, we identified the N-methyl-D-aspartate receptor synaptonuclear signaling and neuronal migration factor (NSMF) as a key replication stress response factor that is important for ataxia telangiectasia and Rad3-related protein (ATR) activation. NSMF localizes rapidly to stalled RFs and acts as a scaffold to modulate replication protein A (RPA) complex formation with cell division cycle 5-like (CDC5L) and ATR/ATR-interacting protein (ATRIP). Depletion of NSMF compromised phosphorylation and ubiquitination of RPA2 and the ATR signaling cascade, resulting in genomic instability at RFs under DNA replication stress. Consistently, NSMF knockout mice exhibited increased genomic instability and hypersensitivity to genotoxic stress. NSMF deficiency in human and mouse cells also caused increased chromosomal instability. Collectively, these findings demonstrate that NSMF regulates the ATR pathway and the replication stress response network for genome maintenance and cell survival.
Falsification and consciousness
Authors: Kleiner Johannes , Hoel Erik
Published: April 2021

The search for a scientific theory of consciousness should result in theories that are falsifiable. However, here we show that falsification is especially problematic for theories of consciousness. We formally describe the standard experimental setup for testing these theories. Based on a theory’s application to some physical system, such as the brain, testing requires comparing a theory’s predicted experience (given some internal observables of the system like brain imaging data) with an inferred experience (using report or behavior). If there is a mismatch between inference and prediction, a theory is falsified. We show that if inference and prediction are independent, it follows that any minimally informative theory of consciousness is automatically falsified. This is deeply problematic since the field’s reliance on report or behavior to infer conscious experiences implies such independence, so this fragility affects many contemporary theories of consciousness. Furthermore, we show that if inference and prediction are strictly dependent, it follows that a theory is unfalsifiable. This affects theories which claim consciousness to be determined by report or behavior. Finally, we explore possible ways out of this dilemma.
ZnO-based micromotors fueled by CO2: the first example of self-reorientation-induced biomimetic chemotaxis
Authors: Mou Fangzhi , Xie Qi , Liu Jianfeng , Che Shengping , Bahmane Lamya , You Ming , Guan Jianguo
Published: April 2021

Synthetic chemotactic micro/nanomotors are envisioned to actively ‘seek out’ targets by following specific chemicals, but they are mainly powered by bioincompatible fuels and only show pseudochemotaxis (or advanced chemokinesis) due to their weak self-reorientation capabilities. Here we demonstrate that synthetic ZnO-based Janus micromotors can be powered by the alternative biocompatible fuel of CO2, and further provide the first example of self-reorientation-induced biomimetic chemotaxis using them. The ZnO-based micromotors are highly sensitive to dissolved CO2 in water, which enables the corrosion of ZnO to continuously occur by providing H+ through hydration. Thus, they can autonomously move even in water exposed to air based on self-diffusiophoresis. Furthermore, they can sense the local CO2 gradient and perform positive chemotaxis by self-reorientations under the phoretic torque. Our discovery opens a gate to developing intelligent micro/nanomotors powered by, and sensitive to, biocompatible atmospheric or endogenous gaseous chemicals for biomedical and environmental applications.
Technological unemployment revisited: automation in a search and matching framework
Authors: Cords Dario , Prettner Klaus
Published: April 2021

Will automation raise unemployment and what is the role of education in this context? To answer these questions, we propose a search and matching model of the labour market with two skill types and with industrial robots. In line with evidence to date, robots are better substitutes for low-skilled workers than for high-skilled workers. We show that robot adoption leads to rising unemployment and falling wages of low-skilled workers and falling unemployment and rising wages of high-skilled workers. In a calibration to Austrian and German data, we find that robot adoption destroys fewer low-skilled jobs than the number of high-skilled jobs it creates. For Australia and the USA, the reverse holds true. Allowing for endogenous skill acquisition of workers implies positive employment effects of automation in all four countries. Thus, the firm creation mechanism in the search and matching model and skill acquisition are alleviating the adverse effects of automation.