bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of psoriasis in children
Authors: Krasnikova V. N. , Chebysheva S. N. , Sakaniya L. R. , Korsunskaya I. M.
Published: November 2022

The prevalence of psoriasis reaches about 3% of the global adult population and is twice as lower in the paediatric population. In children, as well as in adults, psoriasis is associated with several different concomitant pathologies: metabolic syndrome, depression, anxiety, arthritis, etc. However, the diagnosis of psoriasis in children and subsequent treatment is quite a difficult task. The clinical presentation in a pediatric patient differs from the symptoms of the disease in an adult. Psoriatic patches are usually thinner and with less severe desquamation, which is often accompanied by itching, and children are also characterized with unusual regions of rash localization, such as the periaucular or umbilical region. Psoriatic diaper rash is often misdiagnosed as diaper dermatitis. However, diaper psoriasis is the most common manifestation, seen in about 45% of cases in children under two years of age. In children, the presence of psoriasis is associated with an increased risk of metabolic syndrome and its components, and with higher rates of hyperlipidemia, even after weight management, in addition to an observed increased risk of depression and anxiety and a possible increased risk of arthritis and Crohn’s disease. The clinical presentation of pediatric psoriasis is diverse, and the diagnosis is most often made clinically. Auspitz’s sign, Koebner’s phenomenon, and Voronov’s ring might be of some help in clinical diagnosis. The treatment of psoriasis in children is based primarily on the same principles as in adults. However, few of the existing treatment options are approved for use in children and adolescents.
Peculiarities of Food Diversity in the Diet of Children aged 7–18 Using Regional Food Products in the Republic of Sakha (Yakutia)
Authors: Gmoshinskaya M. V. , Lebedeva U. M. , Aleshina I. V.
Published: November 2022

Introduction. Improving the nutrition of schoolchildren and introducing a culture of nutrition with a national component is one of the priority strategic tasks of improving the health of the population.Aim. Study the frequency of consumption of foods with high nutritional value by schoolchildren living in the Republic of Sakha (Yakutia).Materials and methods. According to the developed questionnaire, a survey of 932 parents (legal representatives) of children aged 7–18 was conducted. Statistical processing of the obtained data was carried out using the Excel program using Student’s t-test and Pearson’s χ2 method.Results and discussion. Children living in Yakutia are characterized by a higher frequency of meat consumption, but less consumption of milk and sour-milk drinks, cottage cheese, fish compared to children in the Arctic zone and the Russian Federation as a whole. At least once a week, 31% of local and 30% of alien children consume fish. Despite the presence of meat in the diet, especially of the local population, 40–60% of children consume sausages more than 3 times a week. 70–90% of children consume fruits several times a week and 65–80% vegetables. The number of children consuming sour-milk drinks has increased, and 60–70% of children use them in their diet, whereas previously only 50% consumed them. 10–15% of children of both ethnic groups do not consume milk and sour-milk drinks, cottage cheese – 50–60% of local and 40% of aliens. Both local and alien children began to use national products more often in their diet.Conclusion. In recent years, thanks to complex measures, the food diversity of the diets of schoolchildren living in the Republic of Sakha (Yakutia) has significantly improved, characterized by the inclusion of local traditional products in the diet of both the local and the alien population.
Natural cough remedies: options for a rational choice
Authors: Vakhitov Kh. M. , Pikuza O. I. , Karpova O. A. , Kapralova A. M. , Vakhitova L. F. , Ishbuldina A. V. , Zakirova A. M. , Zinatullin I. R. , Shaymardanova G. R. , Vakhitov E. Kh.
Published: November 2022

This work summarizes the current understanding of the mechanisms providing mucociliary clearance and their disorders in respiratory diseases. It is noted that currently the understanding of the drainage function of the respiratory tract and cough formation in bronchopulmonary pathology has significantly expanded, and therefore much attention is paid to the search for opportunities to correct these parts of pathogenesis. The use of drugs improving sputum rheology and decreasing inflammatory mucosal edema are of great importance in this aspect. The article summarizes the data on the possibilities of pathogenetic correction of respiratory disorders with the emphasis on the use of expectorants and mucolytic drugs made from herbal raw materials. For many of them a sufficiently rich clinical experience has been accumulated, and modern manufacturing techniques have significantly increased their quality and safety. The mucolytic and expectorant properties of modern herbal remedies are in many cases as good as those of synthetic drugs. An important feature of herbal remedies is that they contain a combination of many components with a complex therapeutic effect, whereby the quality of herbal remedies is ensured by the most modern manufacturing control mechanisms. The paper reflects the main therapeutic effects of herbal remedies, which depend on the plant species and are determined by their content of biologically active substances: alkaloids, glycosides (including anthraglycosides, cardiac glycosides, saponins, flavonoids), phytoncides, essential oils, coumarins, tannins, resins, etc. The results of own observations on the use of herbal remedies in routine clinical practice are presented. The high adherence of patients to the use of herbal syrups and drops based on ivy extract in the therapy of cough syndrome in adults and children is shown.
Vitamin D status and levels of pro-inflammatory cytokines in newborns born to mothers with endocrine diseases
Authors: Verisokina N. E. , Klimov L. Ya. , Zakharova I. N. , Zaplatnikov A. L. , Zubkov V. V. , Momotova A. A. , Kuryaninova V. A. , Atanesyan R. A. , Zhelezniakova T. V. , Petrosyan M. A. , Bobryshev D. V. , Volkov D. A. , Magomadova Z. A.
Published: November 2022

Introduction. Vitamin deficiency states are found in 50–80% of pregnant women. Vitamin D deficiency is hazardous because it significantly increases the risk of complications during pregnancy, childbirth, as well as its effect on the child’s condition. Aim. To analyse the relationships between vitamin D status and levels of pro-inflammatory cytokines (IL-1β, IL-6) in children born to mothers with endocrine pathology.Materials and methods. Clinical-anthropometric and laboratory examination included 218 newborns: 98 (45.0%) infants of obese mothers, 32 (14.7%) infants of gestational diabetic mothers with underlying obesity, 22 (10.1%) infants of gestational diabetic mothers, 31 (14.2%) infants of mothers with type I diabetes mellitus and 35 (16.0%) infants of mothers without obesity and signs of impaired glucose tolerance.Results. Severe calcidiol deficiency is more often recorded in infants born to mothers with obesity, gestational diabetes mellitus and type I diabetes mellitus than in infants born to mothers without endocrine pathology. Serum IL-1β level was 2.6 times higher in newborns born to mothers with obesity than in the newborns from the control group — 14.6 (4.7; 36.5) and 5.6 (1.5; 13. 8) pg/ml, respectively (p = 0.04), 2.8 times higher in those born to women with gestational diabetes mellitus with underlying obesity —15.7 (6.5; 54.3) pg/ml (p = 0.02), 4.5 times higher in those born to mothers with gestational diabetes — 25.4 (5.0; 40.5) pg/ml (p = 0.035), and 6.1 times higher in those born to mothers with type I diabetes — 34.3 (3.8; 61.3) pg/ml (p = 0.01). Newborns born to mothers with type 1 diabetes mellitus had a higher serum IL-6 level as compared to the control group — 48.2 (21.3; 75.6) and 20.2 (5.1; 53.2) pg/ml (p = 0.006).Conclusion. Overweight and impaired glucose tolerance in the mother negatively affect the vitamin D sufficiency status, and if a fetus experiences vitamin D deficiency, provoke excessive production of pro-inflammatory cytokines in newborns.
Széllel szemben? - A magyar fertilitás jövőbeli kilátásai
Authors: Drabancz Áron , Berde Éva
Published: November 2022

A jóllét és a fertilitás között fennálló empirikus kapcsolat az elmúlt évtizedben jelentősen megváltozott. Míg a 2000-es évek elején a magasabb fejlettségi szintet elérő európai országokban kissé magasabb fertilitás volt megfigyelhető, addig az elmúlt években végzett kutatások már nem erősítik meg ezeket az eredményeket. Emiatt egyre csökken annak a valószínűsége, hogy a fertilitás érdemben növekvő pályára kerüljön a fejlett országokban, ez Magyarországra is vonatkozik. Elemzésünkben a korábbi népesedési előreszámításokkal egybevetve megvizsgáljuk, hogy miként alakulna Magyarország népessége, amennyiben a fejlett világra jellemző fertilitáscsökkenés Magyarországon is fokozatosan megjelenne. Továbbá azt is megnézzük, hogy mi történne, ha a fertilitás növekvő pályán maradna, és a reprodukciós szinthez szükséges fertilitási értékhez közeledne. Eredményeink megmutatják, hogy ezen alternatív pályák két nagyon eltérő demográfiájú Magyarországhoz vezetnének 2070-re: az alacsonyabb fertilitási pályán a magyar népességcsökkenés drasztikusan felgyorsulna, míg a magas fertilitási pályán a népesség relatíve rövid idő alatt újra növekedne. A 2070-ben megszülető gyermekek száma nagyjából 100 ezer fővel különbözne az eltérő pályákon, azonban az elöregedés mindkét esetben kihívást jelentene.
Profil Mikrorotasi dan Temperatur Aliran Magnetohidrodinamik Fluida Mikrokutub pada Bola Bermagnet
Authors: Fauziyah Mufatin , Widodo Basuki , Adzkiya Dieky
Published: November 2022

Fluida mikrokutub adalah fluida dengan struktur mikro, yang terdiri dari partikel kaku yang berorientasi secara acak pada media kental yang memiliki kemampuan mikrorotasi. Penelitian ini difokuskan pada profil mikrorotasi dan temperatur aliran magnetohidrodinamik fluida mikrokutub pada bola bermagnet. Model dari permasalahan dibangun persamaan dimensional yang terdiri dari persamaan kontinuitas, persamaan momentum, persamaan momentum angular, dan persamaan energi. Model berdimensi tersebut ditransformasikan ke model tak berdimensi menggunakan variabel tak berdimensi. Selanjutnya model tak berdimensi diubah menjadi persamaan similaritas dengan menggunakan variabel similaritas. Persamaan similaritas diselesaikan secara numerik menggunakan metode beda hingga dengan skema implisit Euler. Hasil simulasi menunjukkan temperatur fluida naik seiring dengan meningkatnya parameter bahan mikrokutub. Sebaliknya, temperatur semakin turun dengan bertambahnya bilangan Prandtl. Profil mikrorotasi turun saat parameter bahan mikrokutub lebih besar sampai titik tertentu, kemudian berbalik semakin naik. Profil mikrorotasi semakin meningkat seiring dengan bertambahnya bilangan Prandtl.
Review of hydraulic modelling approaches for intermittent water supply systems
Authors: Sarisen Dondu , Koukoravas Vasilis , Farmani Raziyeh , Kapelan Zoran , Memon Fayyaz Ali
Published: November 2022

Intermittent water supply (IWS) is widely used around the world, and with the increase in population and predicted future water scarcity, IWS applications seem to continue. While most of the existing studies on water supply concentrate on continuous water supply (CWS), the research focused on the IWS is now becoming mainstream. Hydraulic modelling is an effective tool for the process of planning, design, rehabilitation, and operation of water distribution systems. It helps significantly in engineers’ decision-making processes. The necessity of modelling IWS systems arises from the complexity and variety of problems caused by intermittency. This paper offers a review of the state-of-the-art IWS modelling and identifies the key strengths and limitations of the available approaches, and points at potential research directions. Currently, neither computer software nor a practically used approach is available for modelling IWS. For a rigorous simulation of IWS, system characteristics first need to be understood, i.e., the user behaviour under pressure-deficient conditions, water losses, and filling and emptying processes. Each of them requires further attention and improvement. Additionally, the necessity of real data from IWSs is stressed. Accurate modelling will lead to the development of improved measures for the problems caused by intermittency.
Research on pipe burst in water distribution systems: knowledge structure and emerging trends
Authors: Wang Chenwan , Xu Qiang , Qiang Zhimin , Zhou Yan
Published: November 2022

Pipe bursts in water distribution systems (WDSs) lead to large water losses, pollution risks, and public discontent, attracting widespread attention from researchers and water utilities around the world. This study provides insights into the knowledge structure and emerging trends of pipe burst research from a bibliometrics perspective. We used 845 original research and review articles on pipe bursts in the period of January 1991 − June 2022 that cited 16,813 references in the CiteSpace® software for reference co-citation analysis. The results indicate that the knowledge structure of pipe burst research is classified into four categories including pipe burst mechanism, pipe burst detection, pipe burst prediction, and use of sensors. The entire research on pipe bursts advances remarkably. First, pipe burst prediction is the core research category with continuous efforts to improve prediction performance. Second, pipe burst detection is likely to define new research focus to extend existing research focus on pipe burst prediction. Third, computer science and technology are widely and increasingly applied in burst process simulation and data pattern analysis to increase accuracy and effectiveness. This study grasps a full view of current achievements in pipe burst research and provides guidance for future research directions and technological development.
Effect-based monitoring to integrate the mixture hazards of chemicals into water safety plans
Authors: Neale Peta A. , Escher Beate I. , de Baat Milo L. , Dechesne Magali , Deere Daniel A. , Enault Jérôme , Kools Stefan A. E. , Loret Jean-François , Smeets Patrick W. M. H. , Leusch Frederic D. L.
Published: November 2022

Water safety plans (WSPs) are intended to assure safe drinking water (DW). WSPs involve assessing and managing risks associated with microbial, chemical, physical and radiological hazards from the catchment to the consumer. Currently, chemical hazards in WSPs are assessed by targeted chemical analysis, but this approach fails to account for the mixture effects of the many chemicals potentially present in water supplies and omits the possible effects of non-targeted chemicals. Consequently, effect-based monitoring (EBM) using in vitro bioassays and well plate-based in vivo assays are proposed as a complementary tool to targeted chemical analysis to support risk analysis, risk management and water quality verification within the WSP framework. EBM is frequently applied to DW and surface water and can be utilised in all defined monitoring categories within the WSP framework (including ‘system assessment’, ‘validation’, ‘operational’ and ‘verification’). Examples of how EBM can be applied within the different WSP modules are provided, along with guidance on where to apply EBM and how frequently. Since this is a new area, guidance documents, standard operating procedures (SOPs) and decision-making frameworks are required for both bioassay operators and WSP teams to facilitate the integration of EBM into WSPs, with these resources being developed currently.
On the Combination of Harmonics and Polynoms in Econometric Modeling of RUB/AZN Exchange Rate
Authors: Mamedova L. M.
Published: November 2022

Conducting a combinational polynomial and spectral analysis of time series formed on the basis of daily observations of changes in the RUB/AZN exchange rate with pronounced fluctuations for the period 11.05.2017- 02.11.2018 based on computer econometric modeling.

The purpose of the research. The possibility of describing the global rate dynamics by approximation with a combination of a nonlinear polynomial trend and harmonic oscillations of various frequencies relative to this curve; the ability to calculate amplitudes and phases, which can be used to estimate the power spectrum of the Fourier approximation; the ability to develop a high-precision algorithm for predicting exchange rate changes in RUB/AZN.

Materials and methodology. The official statistics of the State Statistics Committee of Azerbaijan were used; classical methods of mathematical analysis and economic analysis; methods of econometrics, harmonic (Fourier) analysis, statistical spectral analysis, “Fourier analysis” of the MS Excel add-in, tools of the Eviews 8 application package with the standard deviation and average approximation error being taken into account, the necessary statistical procedures required for identifying and estimating the parameters of the model and checking its adequacy and accuracy.

Results. By breaking up the empirical analysis of given time series into time-scale polynomial and time-frequency components. Combinations of the optimal degree of variants of polynomials up to the 11th degree and the number of harmonics of sines and cosines of all possible discrete frequencies were revealed.

Conclusion. This result allows us to reconsider the asymmetric impact of RUB/AZN exchange rate pressure on the foreign trade balance between Russia and Azerbaijan. An increase/decrease in exchange rate pressure affects the likelihood of a ruble-manat crisis, while this phenomenon may negatively/positively affect the foreign trade balance and may make it difficult/easier to import resources, goods and services between countries. This, in turn, adds significance to the task of further detailed structuring and analysis of exchange rate changes in RUB/AZN in the face of increased sanction pressures against Russia, thereby actualizing the development of the retrospective part of the study.
Recent Nanoscale Carriers for Therapy of Alzheimer's Disease: Current Strategies and Perspectives
Authors: Zakharova Lucia , Gaynanova Gulnara , Vasilieva Elmira , Vasileva Leysan , Pavlov Rais , Kashapov Ruslan , Petrov Konstantin , Sinyashin Oleg
Published: November 2022

This review covers nanotherapeutic strategies for solving the global problems associated with Alzheimer's disease (AD). The most dramatic factor contributing humanistic, social and economic urgency of the situation is the incurability of the disease, with the drug intervention addressing only AD symptoms and retarding their progress. Key sources behind these challenges are the inability of the early diagnosis of AD, the lack of comprehensive information on the molecular mechanism of the pathogenesis, the bloodbrain barrier obstacles, and the insufficient effectiveness of currently available drugs and therapeutic strategies. The application of nanocarriers allows part of these problems to be solved, together with the improvement of drug bioavailability, prolonged circulation, and overcoming/bypassing the biological barriers. To this date, numerous types and subtypes of nanocarriers are developed and reviewed, the majority of which can be adapted for the treatment of various diseases. Therefore, herein, nanotherapy strategies are specifically categorized in term of the administration routes of AD medicines, with the noninvasive, i.e., transdermal, oral, and intranasal routes emphasized. Further, benefits/ limitations of various nanocarriers are discussed, and perspectives of their application are highlighted.
Variants in CYP2J2 and CYP2C9 Contribute to Susceptibility of Lung Cancer
Authors: Zhang Chan , Li Qi , Cheng Yujing , Yang Xin , Chen Wanlu , He Kunhua , Chen Mingwei
Published: November 2022

Background:

Cytochrome P450 (CYP) enzymes are involved in the metabolism of xenobiotic and carcinogen. In the study, we evaluated the association of CYP2J2 and CYP2C9 variants with lung cancer.

Method:

Five polymorphisms in CYP2J2 and four polymorphisms in CYP2C9 were genotyped in 507 lung cancer patients and 505 controls with Agena MassARRAY platform. The linkage of variants with lung cancer risk was evaluated by odds ratio (OR) and 95% confidence interval (CI) in genetic models and haplotype analyses.

objective:

To elucidate the relationship between the CYP2J2 and CYP2C9 gene polymorphisms and lung cancer susceptibility, we have performed a case-control study.The results shown that these two genetic polymorphisms are associated with lung cancer risk.

Results:

We found that CYP2C9 rs1934967 alleles were associated with lung cancer risk (P < 0.05). In stratified analysis, rs2280274 (women, non-smoker, non-drinker and lymphatic metastasis), rs11207535 (non-smoker and non-drinker), rs10889159 (non-smoker and non-drinker) of CYP2J2, whereas rs1934967 (age ≤ 60m, BMI > 24, squamous carcinoma) of CYP2C9 decreased lung cancer risk (P < 0.05). In addition, the results of linkage disequilibrium (LD) analysis showed that rs2280274|rs4388726 - TG (with adjustment: P = 0.042) of CYP2J2 and rs10509679|rs1934967|rs1934968|rs9332220 – GTGG (without adjustment: P = 0.044) of CYP2C9 were linked with a significantly decreased lung cancer risk.

Conclusion:

Our results indicated genetic variants in CYP2J2 and CYP2C9 might contribute to the susceptibility of lung cancer in Chinese population.

result:

We found that CYP2C9 rs1934967 was significantly linked with lung cancer risk in allele (P = 0.045) and additive (P = 0.049) models. In stratified analysis, rs2280274 (women, non-smoker, non-drinker and lymphatic metastasis), rs11207535 (non-smoker and non-drinker), rs10889159 (non-smoker and non-drinker) of CYP2J2 and rs9332220 (smoker) of CYP2C9 significantly decreased susceptibility of lung cancer (P < 0> 24, squamous carcinoma) of CYP2C9 decreased lung cancer risk (P < 0.05). In addition, two blocks of CYP2J2 and one block of CYP2C9 had strong linkages with increased risk of lung cancer.

other:

The authors had no conflicts of interest to declare.
Comparative Investigation of Fatty Acids in the Mauritania sardinella and
Moroccan Sardine
Authors: Groune A.L. Khalihena , E.l. Hamidi Adnane , Halim Mohammed
Published: November 2022

Aims:

The present study was carried out to evaluate the quality and quantity of lipids
and fatty acids in Mauritanian sardines (Sardinella aurita) and Moroccan sardines (Sardina pilchardus).

Methods:

Gas chromatography/mass spectrometry (GC/MS) and Fourier transform infrared
(FTIR) analyses were adopted thereof.

Results:

the studied samples were found to be very rich in lipids: 17-26% for Mauritanian sardinella
and 45-48% for Moroccan sardine. Thus, GC/MS analyses revealed that the fatty acids
contents in both samples were subdivided into three essential groups: polyunsaturated, monounsaturated
and saturated fatty acids. The semi-quantitative analysis results, calculated using chromatographic
peak areas, have shown that Moroccan sardine is very rich in polyunsaturated fatty
acids (mainly docosahexaenoic (DHA) and ecosapentaenoic (EPA) acids) and monounsaturated
fatty acids (mainly oleic acid), compared to Mauritanian sardinella, who is very rich in monosaturated
fatty acids (mainly palmitoleic acid).

Conclusion:

The lower valuable lipid content of sardinella was probably due to sampling conditions
realized during the reproduction period. On the other hand, the omega-6/omega-3 ratio is
higher in Mauritania sardinella than in Moroccan sardine.
Feasibility analysis of endorphin massage module as an effort to increase breast milk production in puerperal mothers
Authors: Subriah Subriah , Amdadi Zulaeha A. , Arianggara Andi Wilda , Fajriah Siti Nurul , Iskandar Imelda , Jumrah Jumrah
Published: November 2022

This study aims to determine the feasibility of the Endorphin Massage module as a learning medium. The method used in this study is Research and Development (RnD) by adopting the development steps of the Borg and Gall models.  This research was carried out at the Jongaya Health Center, Kassi-Kassi Health Center, and Minasa Upa Health Center in November August 2022. Sampling was carried out using the Purposive Sampling Technique, which was 40 samples, validation test results from media experts averaged 90.9% and validation results from material experts averaged 92.7% which showed that the Endorphin Massage  module is very feasible to use without revision.  The results of user validation (Midwives) in small groups of 10 Midwives with an average eligibility score of 89.5% and the results of large-scale user validation in 30 Midwives with an average eligibility score of 93.4% of the data showed that the Endorphin Massage  module  was very feasible to use. The Endorphin Massage module is suitable for use as a learning medium in an effort to increase breast milk expenditure in Postpartum mothers.
Área de actividad, movimiento y organización social de Heteromys gaumeri Allen y Chapman, 1897 (Rodentia: Heteromyidae) en una Selva Mediana Subcaducifolia de Yucatán, México
Authors: Hernández Betancourt Silvia F. , López Wilchis R. , Cimé Pool J. A. , Medina Peralta S.
Published: November 2022

Se documentó la dinámica del Area de Actividad (AA) y el comportamiento social de Heteromys gaumeri en una selva mediana  subcaducifolia al sur de Yucatán. Se usó el método de captura-recaptura durante cuatro noches por mes de enero de 2000 a diciembre de 2001.  El 34% (n=174) de la población total fue residente, 49% fueron machos y 51% hembras. Las hembras presentaron mayor permanencia que los machos (p<0.05). En ambos sexos las AA y las distancias máximas  recorridas (DMR) de los adultos fueron mayores que las de los  inmaduros (p<0.05) y la estacionalidad no las afectó. Las hembras  reproductivas (gestantes y postlactantes) presentaron menores AA y  DMR que las no reproductivas (p<0.05), mostrando un comportamiento territorial. La sobreposición de las AA fue baja para ambos sexos y  estados reproductivos. En lluvias los machos adultos tuvieron una  mayor sobreposición que las hembras (p<0.05). Los resultados  obtenidos sugieren que H. gaumeri es una especie social, con un  sistema de parejas promiscuo.
PENGARUH METODE LATIHAN ATLETIK DAN KELINCAHAN TERHADAP PENINGKATAN KEBUGARAN JASMANI SISWA SEKOLAH DASAR
Authors: Perdana Anak Agung Octa , Lumintuarso Ria
Published: November 2022

Tujuan penelitian ini untuk mengungkapkan pengaruh metode latihan atletik dan kelincahan terhadap peningkatan kebugaran jasmani siswa sekolah dasar. Penelitian ini menggunakan desain eksperimen faktorial 2 x 2. Untuk menentukan sampel penelitian, terlebih dahulu dilakukan penentuan metode latihan atletik secara acak sederhana (random simple) dengan cara undian, dilanjutkan melakukan tes kelincahan untuk menentukan sampel dengan metode dari Miller. Data dikumpulkan menggunakan Tes Kesegaran Jasmani Indonesia untuk anak usia 10-12 tahun. Data dianalisis menggunakan analisis varian dua jalur ANOVA, uji lanjutan Tukey dengan taraf signifikansi α = 0.05. Hasil penelitian adalah sebagai berikut (1) Ada pengaruh perlakuan kelompok metode latihan kids athletics dan kelompok metode latihan spesialisasi atletik terhadap peningkatan kebugaran jasmani siswa sekolah dasar. (2) Ada pengaruh peningkatan kebugaran jasmani siswa sekolah dasar antara kelompok kelincahan tinggi dan kelompok kelincahan rendah. (3) Ada interaksi antara metode latihan atletik dan kelincahan terhadap peningkatan kebugaran jasmani siswa sekolah dasar. Kelompok metode latihan kids athletics kelincahan tinggi menunjukkan perbedaan rata-rata peningkatan kebugaran jasmani yang lebih baik dibandingkan kelompok lainnya.Kata kunci: atletik, kelincahan, kebugaran jasmani, siswa sekolah dasar EFFECTS OF THE ATHLETICS EXERCISE METHODS AND AGILITY ON THE IMPROVEMENT OF ELEMENTARY STUDENTS’ PHYSICAL FITNESSAbstractThis study aims to investigate effects of the athletics exercise method and agility on the improvement of elementary school students’ physical fitness. The study employed a 2 x 2 factorial experimental design. To determine research sample, a simple random atlethic traning method is applied beforehand by way of lottery, followed by agility test for determining sample using Miller Method.  The data were collected by means of the Indonesian Physical Fitness Test for children aged 10-12 years. They were analyzed using the two-way ANOVA and the post-hoc Tukey test at a significance level of α = 0.05. The results of the study were as follows. (1) There were effects of the treatment using the kids athletics exercise method and that using the athletics specialization exercise method on elementary school students’ physical fitness. (2) There was a difference in the improvement of their physical fitness between those with high agility and those with low agility. (3) There was an interaction between the athletics exercise method and agility on the improvement of elementary school students’ physical fitness. The group with high agility using the kids athletics exercise method showed a higher average improvement of the physical fitness than the other groups.Key words: athletics, agility, physical fitness, elementary school students
The Effectiveness of Internet-Guided Self-help Interventions to Promote Physical Activity Among Individuals With Depression: Systematic Review
Authors: Tang Yiling , Gierc Madelaine , Lam Raymond W , Liu Sam , Faulkner Guy
Published: November 2022

Background

Depression is a prevalent and debilitating mental disorder and a leading cause of disability worldwide. Physical activity (PA) interventions have been shown to alleviate depressive symptoms. However, not all patients have access to PA programing tailored for depression. Internet-guided self-help (IGSH) interventions may be an effective option for increasing PA among people with depression who cannot or prefer not to access supervised exercise treatment.

Objective

We aimed to evaluate the effectiveness of IGSH interventions in increasing PA and alleviating depressive symptoms in people with depression.

Methods

A systematic literature search was conducted for randomized controlled trials and quasiexperimental studies using 9 electronic databases. The review was registered in PROSPERO (2020 CRD42020221713).

Results

A total of 4 randomized controlled trials (430 participants) met the inclusion criteria. Of these, 3 were web-based and 1 was app-based. Three studies found IGSH interventions to have medium to large effects on decreasing depressive symptoms but not on increasing PA compared with waitlist or usual care. One study showed increased self-reported PA but no significant difference in depressive symptoms in the intervention group compared with the control group. Goal setting was the most common behavior change technique used in the interventions. Dropout rates within the intervention groups were relatively low (0%-19%).

Conclusions

Our findings suggested that IGSH PA interventions are feasible and have the potential to reduce depressive symptoms in people with depression. More well-designed and tailored interventions with different combinations of behavior change techniques, particularly those targeting the emotion domain, are needed to assess the overall effectiveness and feasibility of using IGSH interventions to increase PA among people with depression.

Trial Registration

PROSPERO CRD42020221713; https://tinyurl.com/ysaua5bu
Use of the Hashtag #DataSavesLives on Twitter: Exploratory and Thematic Analysis
Authors: Teodorowski Piotr , Rodgers Sarah E , Fleming Kate , Frith Lucy
Published: November 2022

Background

“Data Saves Lives” is a public engagement campaign that highlights the benefits of big data research and aims to establish public trust for this emerging research area.

Objective

This study explores how the hashtag #DataSavesLives is used on Twitter. We focused on the period when the UK government and its agencies adopted #DataSavesLives in an attempt to support their plans to set up a new database holding National Health Service (NHS) users’ medical data.

Methods

Public tweets published between April 19 and July 15, 2021, using the hashtag #DataSavesLives were saved using NCapture for NVivo 12. All tweets were coded twice. First, each tweet was assigned a positive, neutral, or negative attitude toward the campaign. Second, inductive thematic analysis was conducted. The results of the thematic analysis were mapped under 3 models of public engagement: deficit, dialogue, and participatory.

Results

Of 1026 unique tweets available for qualitative analysis, discussion around #DataSavesLives was largely positive (n=716, 69.8%) or neutral (n=276, 26.9%) toward the campaign with limited negative attitudes (n=34, 3.3%). Themes derived from the #DataSavesLives debate included ethical sharing, proactively engaging the public, coproducing knowledge with the public, harnessing potential, and gaining an understanding of big data research. The Twitter discourse was largely positive toward the campaign. The hashtag is predominantly used by similar-minded Twitter users to share information about big data projects and to spread positive messages about big data research when there are public controversies. The hashtag is generally used by organizations and people supportive of big data research. Tweet authors recognize that the public should be proactively engaged and involved in big data projects. The campaign remains UK centric. The results indicate that the communication around big data research is driven by the professional community and remains 1-way as members of the public rarely use the hashtag.

Conclusions

The results demonstrate the potential of social media but draws attention to hashtag usage being generally confined to “Twitter bubbles”: groups of similar-minded Twitter users.
Personalization of Mobile Apps for Health Behavior Change: Protocol for a Cross-sectional Study
Authors: Gosetto Laetitia , Pittavino Marta , Falquet Gilles , Ehrler Frederic
Published: November 2022

Background

Mobile health apps have the potential to motivate people to adopt healthier behavior, but many fail to maintain this behavior over time. However, it has been suggested that long-term adherence can be improved by personalizing the proposed interventions. Based on the literature, we created a conceptual framework for selecting appropriate functionalities according to the user's profile.

Objective

This cross-sectional study aims to investigate if the relationships linking functionalities and profiles proposed in our conceptual framework are confirmed by user preferences.

Methods

A web-based questionnaire comprising several sections was developed to determine the mobile app functionalities most likely to promote healthier behavior. First, participants completed questionnaires to define the user profile (Big Five Inventory-10, Hexad Scale, and perception of the social norm using dimensions of the Theory of Planned Behavior). Second, participants were asked to select the 5 functionalities they considered to be the most relevant to motivate healthier behavior and to evaluate them on a score ranging from 0 to 100. We will perform logistic regressions with the selected functionalities as dependent variables and with the 3 profile scales as predictors to allow us to understand the effect of the participants’ scores on each of the 3 profile scales on the 5 selected functionalities. In addition, we will perform logistic ordinal regressions with the motivation score of the functionalities chosen as dependent variables and with scores of the 3 profile scales as predictors to determine whether the scores on the different profile scales predict the functionality score.

Results

Data collection was conducted between July and December 2021. Analysis of responses began in January 2022, with the publication of results expected by the end of 2022.

Conclusions

This study will allow us to validate our conceptual model by defining the preferred functionalities according to user profiles.

International Registered Report Identifier (IRRID)

RR1-10.2196/38603
The Design, Development, and Implementation of a Web-Enabled Informatics Platform to Enhance the Well-being of Individuals Aged 18-24 Years: Protocol for an Experimental Study
Authors: Malhotra Bhavya , Sahoo Jagannath , Gupta Mansi , Joshi Ashish
Published: November 2022

Background

Well-being is multidimensional, complex, and dynamic in nature. It is an amalgam of physical and mental health, essential for disease prevention and the promotion of a healthy life.

Objective

This study aims to explore the features that impact the well-being of individuals between 18 and 24 years of age in an Indian setting. It further aims to design, develop, and evaluate the usefulness and effectiveness of a web-based informatics platform or stand-alone intervention to enhance the well-being of individuals aged 18-24 years in an Indian setting.

Methods

This study follows a mixed method approach to identify factors influencing the well-being of individuals in the age group of 18-24 years in an Indian setting. The college-going students in this age group from the states of Uttarakhand (urban settings of Dehradun) and Uttar Pradesh (urban settings of Meerut) will be enrolled. They will be randomly allocated to the control and intervention groups. The participants in the intervention group will have access to the web-based well-being platform.

Results

This study will examine the factors that influence the well-being of individuals aged 18-24 years. It will also facilitate the design and development of the web-based platform or stand-alone intervention, which will enhance the well-being of individuals in the age group of 18-24 years in an Indian setting. Furthermore, the results of this study will help generate a well-being index for individuals to plan tailored interventions. The 60 in-depth interviews have been conducted as of September 30, 2022.

Conclusions

The study will help understand the factors that influence the well-being of individuals. The findings of this study will help in the design and development of the web-based platform or stand-alone intervention to enhance the well-being of individuals in the age group of 18-24 years in an Indian setting.

International Registered Report Identifier (IRRID)

PRR1-10.2196/38632
Perceptions and Aspirations Toward Peer Mentoring in Social Media–Based Electronic Cigarette Cessation Interventions for Adolescents and Young Adults: Focus Group Study
Authors: Lyu Joanne Chen , Afolabi Aliyyat , White Justin S , Ling Pamela M
Published: November 2022

Background

Social media offer a promising channel to deliver e-cigarette cessation interventions to adolescents and young adults (AYAs); however, interventions delivered on social media face challenges of low participant retention and decreased engagement over time. Peer mentoring has the potential to ameliorate these challenges.

Objective

The aim of this study was to understand, from both the mentee and potential mentor perspective, the needs, expectations, and concerns of AYAs regarding peer mentoring to inform the development of social media–based peer mentoring interventions for e-cigarette cessation among AYAs.

Methods

Seven focus groups, including four mentee groups and three potential mentor groups, were conducted with 26 AYAs who had prior experience with e-cigarette use and attempts to quit in the context of a social media–based e-cigarette cessation intervention. Discussion focused on preferred characteristics of peer mentors, expectations about peer mentoring, mentoring mode, mentor training, incentives for peer mentors, preferred social media platforms for intervention delivery, supervision, and concerns. Focus group transcripts were coded and analyzed using a thematic analysis approach.

Results

Overall, participants were receptive to peer mentoring in social media–based cessation interventions and believed they could be helpful in assisting e-cigarette cessation. Participants identified the most important characteristics of peer mentors to be of similar age and to be abstinent from e-cigarette use. Participants expected peer mentors would share personal experiences, provide emotional support, and send check-ins and reminders. Peer mentors supporting a group of mentees in combination with one-on-one mentoring as needed was the preferred mentoring mode. A group of 10 mentees with a mentor:mentee ratio of 1:3-5 was deemed acceptable for most participants. Participants expressed that mentor training should include emotional intelligence, communication skills, and the scientific evidence about e-cigarettes. Although monetary incentives were not the main motivating factor for being a peer mentor, they were viewed as a good way to compensate mentors’ time. Instagram was considered an appropriate social media platform to deliver a peer-mentored intervention due to its functionality. Participants did not express many privacy concerns about social media–based peer mentoring, but mentioned that boundaries and community agreements should be set to keep relationships professional.

Conclusions

This study reflects the needs and preferences of young people for a peer mentoring intervention to complement a social media program to support e-cigarette cessation. The next step will be to establish the feasibility, acceptability, and preliminary efficacy of such a peer mentoring program.
How do people who self-harm evaluate online lived experience stories? A focus group study (Preprint)
Authors: Winstone Lizzy , Mars Becky , Ferrar Jennifer , Moran Paul , Penton-Voak Ian , Grace Lydia , Biddle Lucy
Published: November 2022

BACKGROUND

The positive and negative effects of interacting with online content on mental health and especially self-harm, are well documented. Lived experience stories are one such type of static online content, frequently published on healthcare or third sector organization websites, as well as social media and blogs, as a form of support for those seeking help online.

OBJECTIVE

To increase understanding about how people who self-harm engage with and evaluate online lived experience stories.

METHODS

Four online focus groups were conducted with thirteen people with recent self-harm experience (aged 16-40 years). Three example lived experience stories were read aloud to participants, who were then asked to share their reactions to the stories. Participants were also encouraged to reflect on stories previously encountered online. Data were analysed thematically.

RESULTS

Five themes were generated: i) stories of recovery from self-harm and their emotional impact; ii) impact on self-help and help-seeking behaviors; iii) identifying with the narrator; iv) authenticity; v) language and stereotyping.

CONCLUSIONS

Lived experience stories published online can provide a valuable form of support for those experiencing self-harm. They can be motivating and empowering for the reader, as well as having the potential to distract from urges to self-harm. However, these effects are moderated by age, and narratives of recovery may demoralise older readers. Our findings have implications for organizations publishing lived experience content, and for community guidelines and moderators of online forums in which users share their stories. These include the need to consider the narrator’s age, relatability and authenticity of their journey, and to avoid using stigmatizing language.
Personal Health Data Tracking by Blind and Low-Vision People: Survey Study (Preprint)
Authors: Lee Jarrett G W , Lee Kyungyeon , Lee Bongshin , Choi Soyoung , Seo JooYoung , Choe Eun Kyoung
Published: November 2022

BACKGROUND

Personal health technologies, including wearable tracking devices and mobile apps, have great potential to equip the general population with the ability to monitor and manage their health. However, being designed for sighted people, much of their functionality is largely inaccessible to the blind and low-vision (BLV) population, threatening the equitable access to personal health data (PHD) and health care services.

OBJECTIVE

This study aims to understand why and how BLV people collect and use their PHD and the obstacles they face in doing so. Such knowledge can inform accessibility researchers and technology companies of the unique self-tracking needs and accessibility challenges that BLV people experience.

METHODS

We conducted a web-based and phone survey with 156 BLV people. We reported on quantitative and qualitative findings regarding their PHD tracking practices, needs, accessibility barriers, and work-arounds.

RESULTS

BLV respondents had strong desires and needs to track PHD, and many of them were already tracking their data despite many hurdles. Popular tracking items (ie, exercise, weight, sleep, and food) and the reasons for tracking were similar to those of sighted people. BLV people, however, face many accessibility challenges throughout all phases of self-tracking, from identifying tracking tools to reviewing data. The main barriers our respondents experienced included suboptimal tracking experiences and insufficient benefits against the extended burden for BLV people.

CONCLUSIONS

We reported the findings that contribute to an in-depth understanding of BLV people’s motivations for PHD tracking, tracking practices, challenges, and work-arounds. Our findings suggest that various accessibility challenges hinder BLV individuals from effectively gaining the benefits of self-tracking technologies. On the basis of the findings, we discussed design opportunities and research areas to focus on making PHD tracking technologies accessible for all, including BLV people.

CLINICALTRIAL
Developing Implementation Strategies to Support the Uptake of a Risk Tool to Aid Physicians in the Clinical Management of Patients With Syncope: Systematic Theoretical and User-Centered Design Approach (Preprint)
Authors: Rouleau Geneviève , Thiruganasambandamoorthy Venkatesh , Wu Kelly , Ghaedi Bahareh , Nguyen Phuong Anh , Desveaux Laura
Published: November 2022

BACKGROUND

The Canadian Syncope Risk Score (CSRS) was developed to improve syncope management in emergency department settings. Evidence-based tools often fail to have the intended impact because of suboptimal uptake or poor implementation.

OBJECTIVE

In this paper, we aimed to describe the process of developing evidence-based implementation strategies to support the deployment and use of the CSRS in real-world emergency department settings to improve syncope management among physicians.

METHODS

We followed a systematic approach for intervention development, including identifying who needs to do what differently, identifying the barriers and enablers to be addressed, and identifying the intervention components and modes of delivery to overcome the identified barriers. We used the Behaviour Change Wheel to guide the selection of implementation strategies. We engaged CSRS end users (ie, emergency medicine physicians) in a user-centered design approach to generate and refine strategies. This was achieved over a series of 3 qualitative user-centered design workshops lasting 90 minutes each with 3 groups of emergency medicine physicians.

RESULTS

A total of 14 physicians participated in the workshops. The themes were organized according to the following intervention development steps: theme 1—identifying and refining barriers and theme 2—identifying the intervention components and modes of delivery. Theme 2 was subdivided into two subthemes: (1) generating high-level strategies and developing strategies prototypes and (2) refining and testing strategies. The main strategies identified to overcome barriers included education in the format of meetings, videos, journal clubs, and posters (to address uncertainty around when and how to apply the CSRS); the development of a web-based calculator and integration into the electronic medical record (to address uncertainty in how to apply the CSRS); a local champion (to address the lack of team buy-in); and the dissemination of evidence summaries and feedback through email communications (to address a lack of evidence about impact).

CONCLUSIONS

The ability of the CSRS to effectively improve patient safety and syncope management relies on broad buy-in and uptake across physicians. To ensure that the CSRS is well positioned for impact, a comprehensive suite of strategies was identified to address known barriers.