bluuebunny/crossref_metadata_2025 huggingface dataset:
La diversidad familiar y su influencia en las habilidades sociales de los niños y niñas de 3 a 4 años
Authors: Blanco Carbono Nini Johana , Acosta Castañeda Jennifer Inés , Romero Ortiz María Fanyanny
Published: June 2024

Las habilidades sociales durante la infancia son fundamentales para el desarrollo integral del ser humano. Esta investigación se enfoca en analizar la influencia de la diversidad familiar en las habilidades sociales de niños de 3 a 4 años del CDI de Bogotá durante los años 2023 y 2024. Para llevar a cabo este estudio, se realiza una revisión bibliográfica que aborda conceptos clave relacionados con habilidades sociales, centrados en la comunicación, las emociones, las relaciones y los vínculos, así como en la educación infantil y la diversidad familiar. Se destaca el marco normativo local e internacional. El método seleccionado fue la Etnografía Educativa, debido a que implica una observación participante de un fenómeno cultural como lo son las habilidades sociales. Además, se emplearon dos técnicas: la observación participante a través de una ficha de observación y la ficha de caracterización del CDI, así como el grupo focal. La triangulación de datos se empleó con el fin de obtener una comprensión de la dinámica observada en el CDI, utilizando una muestra de 10 niños y niñas de 3 a 4 años, junto con sus respectivas familias que también permitió llegar a los hallazgos y resultados obtenidos destacando especialmente la diversidad familiar y su influencia en las habilidades sociales de los niños y las niñas. La diversidad familiar se aborda considerando diversas estructuras familiares, reconociendo la influencia de la cultura y destacando las diferencias regionales en Colombia, así como su impacto en la diversidad. Palabras clave: de tres a cinco palabras clave separadas por comas con primera letra en minúscula.
Examining arts psychotherapies practice elements: Early findings from the Horizons Project
Authors: Havsteen-Franklin Dominik , Maratos Anna , Usiskin Miriam , Heagney Mary
Published: June 2024

Background: Arts Psychotherapies (art, music, drama and dance/movement) have been integral to mental health care services for several decades, however consensus and transparency about the clinical process is still being established. This study investigates practice with a team of six arts psychotherapists working with severe mental illnesses in London, inpatient and community services. The study examines what in-session practice elements are used, whether there is consensus about what the practice elements are and why the arts therapists use them.  
Method: The methods employed in the first phase of the project are interview-based with thematic analysis, repertory grid technique and nominal group techniques used to analyse the data with the aim of triangulating results to establish greater validity.
Results: The results showed that there is scope for developing a shared language about in-session practice elements within a mental health context. However the research examining the timing and reasons for employing those practice elements is still being undertaken. In this study the first results from an extract of the interviews illustrates a complex relationship between theory and practice.
Conclusion: From the findings so far it would appear that within this specific context it is possible to see that there are ways of categorising the therapist’s actions that becomes comparable across the arts psychotherapies. From the therapist’s personal descriptions of his or her own practice, there also appears to be a close correlation between arts psychotherapies in a mental health community and inpatient context. Additionally, evidence-based practice models such as mentalisation-based therapies appear to have a close correlation.
Timing of cardio-oncological rehabilitation and cardiorespiratory fitness in patients receiving cardiotoxic chemotherapy: a longitudinal observational study
Authors: Schneider Caroline , Dierks Annika , Rabaglio Manuela , Campbell Kristin L. , Wilhelm Matthias , Eser Prisca
Published: June 2024

AIMS: Anthracycline-based chemotherapy has well-known cardiotoxic effects, butmay also cause skeletal muscle myopathy and negatively affect cardiorespiratory fitness and quality of life. The effectiveness of exercise training in improving cardiorespiratory fitness and quality of life during chemotherapy is highly variable. We set out to determine how the effect of exercise training on cardiorespiratory fitness (primary outcome) and quality of life (secondary outcome) in cancer patients is affected by the type of therapy they receive (cardiotoxic therapy with or without anthracyclines; non-cardiotoxic therapy) and the timing of the exercise training (during or after therapy).
METHODS: Consecutive patients with cancer who participated in an exercise-based cardio-oncology rehabilitation programme at a university hospital in Switzerland between January 2014 and February 2022 were eligible. Patients were grouped based on chemotherapy (anthracycline vs non-anthracycline) and timing of exercise training (during vs after chemotherapy). Peak oxygen uptake (VO2) was assessed with cardiopulmonary exercise testing (n = 200), and quality of life with the Functional Assessment of Cancer Therapies questionnaire (n = 77). Robust linear models were performed for change in peak VO2 including type and timing of cardiotoxic therapies, age, training impulse and baseline peak VO2; change in quality of life was analysed with cumulative linked models.
RESULTS: In all patients with valid VO2 (n = 164), median change in peak VO2 from before to after exercise training was 2.3 ml/kg/min (range: –10.1–15.9). The highest median change in peak VO2 was 4.1 ml/kg/min (interquartile range [IQR]: 0.7–7.7) in patients who completed exercise training during non-anthracycline cardiotoxic or non-cardiotoxic therapies, followed by 2.8 ml/kg/min (IQR: 1.2–5.3) and 2.3 ml/kg/min (IQR: 0.1–4.6) in patients who completed exercise training after anthracycline and after non-anthracycline cardiotoxic or non-cardiotoxic therapies, respectively. In patients who completed exercise training during anthracycline therapy, peak VO2 decreased by a median of –2.1 ml/kg/min (IQR: –4.7–2.0). In the robust linear model, there was a significant interaction between type and timing of cancer treatment for anthracycline therapy, with greater increases in peak VO2 when exercise training was performed after anthracycline therapy. For quality of life, higher baseline scores were negatively associated with changes in quality of life.
CONCLUSION: In our cohort, the increase in cardiorespiratory fitness was diminished when exercise training was performed concurrently with anthracyclines. For patients with cardiotoxic treatments other than anthracyclines, cardiorespiratory fitness and quality of life was not associated with timing of exercise training.
Lipedema Adipocytes in Culture: Signs of Hypertrophy, Inflammation, and Fibrosis
Authors: Maria Ernst Anna , Schimak Erwin , Steiner Marianne , Lipp Anna-Theresa , Bauer Hans-Christian , Bauer Hannelore
Published: June 2024

Despite extensive research during the last couple of years, lipedema still appears enigmatic in respect to its pathogenesis. In our in vitro study, we have set out to further characterize lipedema adipocytes, concentrating on gene and protein expression, which might help to develop ideas explaining the excessive accumulation of adipose tissue in women with lipedema. Using 2D cultures we show that gene expression in lipedema and non-lipedema adipocytes differs significantly in terms of genes related to lipid droplet size determination, insulin signaling and glucose uptake. A pronounced hypertrophy, recognizable by a significantly increased average lipid droplet size, was visible in differentiated lipedema adipocytes grown in 3D cultures. In addition, gene and protein expression related to inflammation and fibrosis were upregulated in lipedema adipocytes compared to controls, supporting earlier reports. Taken together, results from our in vitro studies suggest that lipedema adipose cells are capable of retaining their hypertrophic nature under culture conditions and open new aspects focusing on insulin signaling and PDGFRA-mediated balancing of adipogenic versus fibrogenic differentiation of lipedema adipose tissue.
Hypereosinophilia in Summary
Authors: Akkaya Fırat Asuman
Published: June 2024

Eosinophils are white blood cells. They are found in various cellular arrays. Eosinophils play a role in the fight against many parasitic infections. Eosinophilic asthma, nasal polyps, eosinophilic gastrointestinal disorders, polyangiitis, and eosinophilic granulomatosis are diseases referring hypereosinophilic syndrome. Eosinophil granules participate in tissue healing, damage, repair and restructuring processes thanks to proteins and chemical mediators. Interleukin (IL)-5, IL-4, and IL-13′ play a role in the proliferation, maturation, activation, and recruitment of eosinophils. Eosinophils have receptors for various cytokines, chemokines, and adhesion molecules that allow them to participate in inflammatory activities. In response to stimuli, eosinophils may release a range of granule proteins, including major basic proteins (MBPs) 1–2, eosinophil cationic protein (ECP), eosinophil peroxidase (EPX), eosinophil-derived neurotoxin (EDN), cytokines, and cytosolic Charcot-Leyden crystal protein/ galectin-10 (CLC/Gal-10). Eosinophils participate in a variety of biological processes and contribute to both normal and pathological processes. Improvements can be made in understanding the pathophysiological mechanisms of these diseases. It has led to the development of new therapeutics for eosinophilic inflammatory diseases.
Thyroid Nodules and Biopsy
Authors: Serdar Deniz Muzaffer
Published: June 2024

The present chapter provides an in-depth review of the prevalence, diagnostic challenges, and management strategies for thyroid nodules, emphasizing the integration of various diagnostic modalities to enhance precision and guide therapeutic decisions. Thyroid nodules are frequently encountered in clinical settings, with a significant proportion detected incidentally. While most are benign, the potential for malignancy necessitates careful evaluation, primarily through ultrasound-guided fine-needle aspiration (FNA). However, FNA has limitations, including unsatisfactory and indeterminate results, which may lead to unnecessary interventions. The chapter discusses the evolution of diagnostic techniques, including the role of ultrasonography, molecular diagnostics, and core needle biopsy, alongside traditional FNA. It highlights recent clinical experiences and studies that address diagnostic ambiguities, aiming to optimize patient outcomes by reducing unnecessary surgeries and improving diagnostic accuracy. The impact of external factors, such as the COVID-19 pandemic on thyroid nodule diagnostics, is explored. Through a comprehensive analysis, the chapter seeks to provide clinicians with updated strategies and insights into managing thyroid nodules effectively in diverse clinical contexts.
Anatomic Completeness, Variations, Patency, and Functional Assessment of Circle of Willis: Implications for Chronic Aortic Dissection and Non-Emergent Arch Surgery
Authors: Nenna Antonio , Corrado Diletta , Loreni Francesco , Ferrisi Chiara , Sorrentino Gennaro , Giacinto Omar , Barbato Raffaele , Mastroianni Ciro , Lusini Mario , Chello Massimo
Published: June 2024

Circle of Willis (CoW) variations are present in a significant number of patients. In patients undergoing non-emergent surgery for aortic dissection (e.g., chronic dissection or planned complex aortic arch surgery), an extensive preoperative examination is warranted as anatomic completeness, variation, patency, and functional assessment of CoW is crucial to optimize neuroprotection strategies. In non-emergent clinical presentations, unilateral or bilateral selective cerebral perfusion should be tailored to patient’s anatomy to minimize intraoperative risk and improve outcomes. A new classification system provides a simple and comprehensive ontology of the described anatomical variations of the CoW. An accurate preoperative assessment might indicate the need for adjunctive perfusion in selected CoW configurations.
Anatomy and Physiology of the Uveal Tract: Maintaining the Eye’s Internal Balance
Authors: Kumar Raj , Kumar Sunil , Kumar Attuluri Vamsi
Published: June 2024

The uveal tract, comprising the iris, ciliary body, and choroid, is pivotal in maintaining the eye’s internal balance. The iris, with its pigmentation, regulates light entry through pupil control and contributes to eye color variation. The ciliary body, positioned behind the iris, facilitates accommodation by adjusting the lens for focusing at various distances and produces aqueous humor, crucial for intraocular pressure maintenance. The choroid, a vascular layer at the back of the eye, nourishes the retina. Together, these components uphold eye shape, control light entry, and support retinal function. Understanding uveal anatomy and physiology is fundamental to comprehending ocular mechanisms, encompassing both structural integrity and functional dynamics. This book chapter provides a knowledge of uveal anatomy and physiology.
Chemical Vapor Deposition Synthesis of Carbon Nanomaterials over Lanthanum-Nickel Co-Loaded Catalyst Supported on Novel Radially Aligned Nano Rutile
Authors: Dziike Farai , J. Franklyn Paul , Deenadayalu Nirmala
Published: June 2024

Deposition-precipitation using urea (DPU) method was efficiently used to load lanthanum and nickel catalyst nanoparticles onto the radially aligned nano rutile (RANR) support material to achieve a metal loading ranging from 1 to 10 wt. % La-Ni/RANR co-loaded supported catalysts. The PXRD peaks due to La occurred at 2θ values <30° and increased in intensities with an increase in La wt. % loading. The occurrence and distribution of the catalyst metal phases were analyzed using wavelength dispersive spectroscopy mapping (WDS) of the electrode probe microanalysis technique (EPMA). The reduction profiles showed TPR peaks that shifted to higher temperatures with an increase in metal wt. % loading. TEM micrographs of the La-Ni/RANR-supported catalysts showed that at different wt. % loadings, the particles deposited take different shapes and sizes with polydisperse La-Ni nanoparticles assuming a short rod-like structure at 1% wt loading. The La-Ni/RANR catalyst directly affected and influenced the nature of the carbon nanomaterials in CVD reactions under different parametric conditions of varied wt. % composition, temperature, flow rate, and time. It was concluded that the straight CNFs were catalyzed by the La end, while the coiled or twisted CNFs were catalyzed by the Ni end of this catalyst.
Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center
Authors: Edek Yusuf Can , Aypek Yağmur , Öğüt Betül , Erdem Özlem , Adışen Esra
Published: June 2024

Introduction: Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions. Objectives: In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options. Methods: This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital. Results: A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents. Conclusions: Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.
Photodynamic Therapy for the Treatment of Basal Cell Carcinoma: A Comprehensive Review of Randomized Controlled Trials
Authors: Koumprentziotis Ioannis-Alexios , Rompoti Natalia , Liopyris Konstantinos , Nicolaidou Electra , Stratigos Alexander
Published: June 2024

Introduction: Basal cell carcinoma (BCC) is the most common skin cancer worldwide and has been reported to have a rising incidence in the last years. Multiple therapeutic modalities are approved for the treatment of BCC, making it difficult for physicians to choose the most suitable option for every patient. Photodynamic therapy (PDT) using either 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) as photosensitizing agents is an established treatment option for low-risk BCC. Objectives: This review aims to summarize the available evidence from randomized clinical trials (RCTs) that utilize either ALA or MAL PDT and compare it with other treatment modalities. The main outcomes related to the effectiveness, adverse events, cosmetic outcomes and pain sensation, along with data from long-term follow-ups will be presented and discussed. Methods: Thorough literature searches were conducted through the electronic databases ClinicalTrials.gov and Pubmed/MEDLINE from inception up to 28 March 2023. Only studies in English were included. All relevant data were extracted accordingly from the eligible studies. Results: Eight RCTs included superficial BCC (sBCC) alone, 7 included nodular BCC (nBCC), 2 included both sBCC and nBCC and 1 included BCC of unspecified subtype. Follow-up duration ranged from 3 months to 5 years. Both ALA-PDT and MAL-PDT demonstrated acceptable efficacy, adverse events, cosmetic outcomes and pain sensation while no major differences were observed between them. PDT was less effective than surgery but with better reported cosmetic outcomes. Conclusions: PDT is a safe and efficacious treatment option for sBCC and to a lesser extent nBCC.
Dermatology Quality of Life and Depressıon Anxiety and Stress-42 Scale in Scabies Patients
Authors: Karadoğan Serap , Ulgen Altay Berna
Published: June 2024

Introduction: Scabies is a pruritic skin infestation with a globally increasing prevalance. Sleep problems, dispaired social and personal interactions, mainly due to itching, have been reported. Objectives: We aimed to determine the influence of scabies on quality of life and psychosocial health using Dermatology Quality of Life Index (DQOL) and Depression Anxiety and Stress-42 (DASS-42) Scale and analyse whether there is a correlation between the two scales and any sociodemographic and clinical characteristics. Methods: Scabies patients (>16 years) who presented to our Outpatient Clinics were enrolled. Age, gender, occupation, marital status and education level and clinical features were recorded. DQOL Index and DASS-42 Scale were used. Possible influence of demographic and clinical characteristics on total scores were analysed. The Spearman coefficient analysis was performed to determine whether there is a correlation between these scores. Results: Of 92 patients (mean age:37.76±15.355, Female/Male: 1.09/1) 63% were married and 35.9% were high-school graduates; 27.2% and 23.9% were housewives and officer-proffesionals. Disease was generalized in 57.6% and duration of disease was mostly <4 weeks. Mean DQOL and DASS-42 scores were 13,16±7,638 and 42.10±30.644, respectively. Symptoms/feelings were affected predominantly. DQOL was affected ‘severely’ in 41.3% of patients. Conclusions: Impairment of DQOL is a significant predictive parameter for higher DASS levels. Scabies is not only associated with impairment in DQOL but may also lead to psychosocial problems. All scabies patients should be evalauted and consulted –if needed- for possible problems of psychosocial status including depression, anxiety and stress as well as clinical symptoms and secondary complications.
Long-Term Effectiveness of Brodalumab for the Treatment of Moderate-To-Severe Psoriasis: A Real-Life Multicenter Study of Up to 3 Years in a Real-Life Italian Cohort
Authors: Caldarola Giacomo , Galluzzo Marco , Bernardini Nicoletta , Botti Elisabetta , De Luca Eleonora , De Simone Clara , Mariani Marco , Moretta Gaia , Pallotta Sabatino , Campione Elena , Peris Ketty
Published: June 2024

Introduction: Data about the long-term effectiveness of brodalumab could be valuable in assessing patient adherence to treatment and improving psoriasis management. Objective: The aim of our study was to evaluate the drug survival of brodalumab and identify any predictive factors for discontinuation. Methods: A multicenter retrospective study was conducted in patients with moderate-to-severe psoriasis who were treated for up to 3 years. We extracted data from patient files, related to the characteristics of the patients and the disease. Drug survival analysis was descriptively analyzed using Kaplan–Meier survival curves. Univariable and multivariable analyses were performed to assess baseline patient characteristics that predicted clinical response. Results: The study included 90 patients. Among them, 28 (31.1%) suspended brodalumab through the observation period. At weeks 52, 104 and 156 the median PASI score were 0.0 [0.0 – 0.8], 0.0 [0.0 – 1.0] and 0.0 [0.0 – 0.0], respectively.  The estimated cumulative survival rates at weeks 52 and 104 were 86.32% and 78.09%, respectively. In the multivariable survival analysis, predictor factors for overall discontinuation included body mass index (BMI) (OR 1.10, 95% CI 1.03 - 1.18), baseline PASI (OR 1.06, 95% CI 1.02 - 1.10), and psoriatic arthritis (OR 5.05, 95% CI 0.89 - 13.50). Conclusions: Brodalumab has shown long-term effectiveness for up to 3 years. Considering baseline disease severity and patient characteristics could aid in optimizing the long-term management of psoriasis.
Bimekizumab for the Treatment of Plaque Psoriasis With Involvement of Genitalia: A 16-Week Multicenter Real-World Experience—IL PSO (Italian Landscape Psoriasis)
Authors: Orsini Diego , Malagoli Piergiorgio , Balato Anna , Bianchi Luca , Brianti Pina , Buononato Dario , Burlando Martina , Caldarola Giacomo , Campanati Anna , Campione Elena , Carrera Carlo G. , Carugno Andrea , Cusano Francesco , Dapavo Paolo , Dattola Annunziata , De Simone Clara , Dini Valentina , Esposito Maria , Fargnoli Maria C. , Gaiani Francesca M. , Gargiulo Luigi , Gisondi Paolo , Giunta Alessandro , Ibba Luciano , Lasagni Claudia , Loconsole Francesco , Maione Vincenzo , Mortato Edoardo , Marzano Angelo V. , Maurelli Martina , Megna Matteo , Mercuri Santo R. , Narcisi Alessandra , Offidani Annamaria , Paolino Giovanni , Parodi Aurora , Pellacani Giovanni , Potestio Luca , Quaglino Pietro , Richetta Antonio G. , Romano Francesca , Sena Paolo , Venturini Marina , Assorgi Chiara , Costanzo Antonio
Published: June 2024

Introduction: Genital involvement is observed in approximately 60% of patients with psoriasis, presenting clinicians with formidable challenges in treatment. While new biologic drugs have emerged as safe and effective options for managing psoriasis, their efficacy in challenging-to-treat areas remains inadequately explored. Intriguingly, studies have shown that interleukin (IL)-17 inhibitors exhibit effectiveness in addressing genital psoriasis. Objectives: We aimed to determine the effectiveness profile of bimekizumab in patients affected by moderate-to-severe plaque psoriasis with involvement of genitalia. Methods: Bimekizumab, a dual inhibitor of both IL-17A and IL-17F, was the focus of our 16-week study, demonstrating highly favorable outcomes for patients with genital psoriasis. The effectiveness of bimekizumab was evaluated in terms of improvement in Static Physician's Global Assessment of Genitalia (sPGA-G) and Psoriasis Area and Severity Index. Results: Sixty-five adult patients were enrolled. Remarkably, 98.4% of our participants achieved a clear sPGA-G score (s-PGA-g=0) within 16 weeks. Moreover, consistent improvements were observed in PASI scores, accompanied by a significant reduction in the mean Dermatology Life Quality Index (DLQI), signifying enhanced quality of life. Notably, none of the patients reported a severe impairment in their quality of life after 16 weeks of treatment.  In our cohort of 65 patients, subgroup analyses unveiled that the effectiveness of bimekizumab remained unaffected by prior exposure to other biologics or by obesity. Conclusions: Our initial findings suggest that bimekizumab may serve as a valuable treatment option for genital psoriasis. Nevertheless, further research with larger sample sizes and longer-term follow-up is imperative to conclusively validate these results.
Những điểm nổi bật trong lĩnh vực can thiệp mạch máu ngoại biên năm 2023
Authors: Đinh Huỳnh Linh , Nguyễn Tuấn Hải , Tạ Mạnh Cường
Published: June 2024

Trong năm 2023, có một số nghiên cứu mới trong lĩnh vực can thiệp mạch máu ngoại biên. Tạp chí Tim mạch học xin điểm lại 2 điểm nổi bật có thể dẫn đến các thay đổi trong thực hành lâm sàng.
Current population size and risk status of the indigenous endangered Sheko cattle breed in south-west Ethiopia
Authors: Z. Admasu  , E. Bayou
Published: June 2024

This study assessed the current population size and risk status of the indigenous endangered Sheko cattle breed in four zones of South West Ethiopia. The Sheko cattle breed, known as the last remnants of Africa’s original Bos taurus cattle and the only trypanotolerant breed in Ethiopia, is facing a decline in their effective population size. The estimated population size of Sheko cattle is approximately 7252, with varying levels of genetic purity based on physical observations. The distribution of genetic purity levels of Sheko cattle indicates that there are approximately 4073, 2934, and 1145 individuals at the 1st (>80% pure), 2nd (>60% pure), and 3rd (>40% pure) levels, respectively. The breed is at risk due to factors such as aggressive behavior, interbreeding with zebu breeds, lack of pure Sheko bulls, and lack of awareness creation. To conserve the Sheko cattle breed, measures such as backcrossing to purebreds, genetic monitoring and evaluation, molecular characterization, assessment of genetic admixture and inbreeding, and collaboration among stakeholders are essential. Overall, this research emphasizes the urgent need for coordinated efforts to safeguard the genetic diversity and population size of the Sheko cattle breed.
Pre-extension demonstration of inter-cropping of improved forages with food and cash crops at Semen Bench Woreda, Southwest Ethiopia
Authors: Hailu Teklu , Begna Regasa
Published: June 2024

Pre-extension demonstration study was conducted in the North Bench district, Bench Sheko Zone, South-western Region, Ethiopia, in 2020/2021 main cropping season. The objective of the study was to demonstrate fodder production from improved forage legumes intercropped in food and cash crops and to evaluate the nutritional quality and compatibility of forage legumes. Three forage legumes, namely lablab, vetch, and cowpea, intercropped in maize, whereas alfalfa and desmodium intercropped in coffee. The demonstration was laid out in a randomized complete block design with ten replications on a farmer’s farm field with a participatory approach. The legumes were intercropped in maize three weeks after maize planting. The results revealed that maize plant height, maize grain yield, and maize stover biomass yields were not significantly (p > 0.05) different among treatments. However, significantly higher legume biomass yield and total biomass yield were obtained from maize-lablab-based intercropping as compared to maize-vetch and maize-cowpea-based intercropping systems. Similarly, the maize-lablab-based intercropping system recorded a significantly (p < 0.05) higher crude protein yield. The lower legume biomass yields were obtained from desmodium and alfalfa intercropped in coffee. Participant farmers were also very interested in forage production from maize-lablab-based intercropping systems as compared to maize-vetch, maize-cow pea, desmodium-coffee, and alfalfa-coffee-based intercropping systems. Therefore, farmers are recommended to intercrop lablab in maize to overcome the animal feed shortage in the study area.
A STUDY ON PLACING ARTICLES AND ITS DIFFICULTIES EXPERIENCED BY THE L2 LEARNERS OF FIRST YEAR ENGINEERING STUDENTS
Authors: Deepa Dr. R.
Published: June 2024

This study is about placing the Articles at right place by identifying the consonants and vowel sound and also by following the rules and its functions for constructive learning platform for the L2 learners because placing the Articles at right place reveals the thorough knowledge in Grammar. For this study the data has been collected from the first year Mechatronics Engineering Students to identify their knowledge in placing the articles and the difficulties experienced by the L2 learners. The total target of the students for this study is 35.
A CRITICAL STYLISTIC ANALYSIS OF ALTERNATIVE POSSIBLE WORLDS AND DEICTIC PROJECTIONS IN RABINDRANATH TAGORE’S WHERE THE MIND IS WITHOUT FEAR
Authors: Mugalikar Jyoti
Published: June 2024

Critical Stylistics as the study of language in literature has a potent impact on the content and intent of the human mind. The subtext of the conjugation of the narrative technique with the careful stylistic style enlightens the harmony of language, mind and literature. The focus, theme, prominence of the varying predicates contribute to the concept lexicon of the reader. The varying contexts of language use (regional, social, cultural and ideological) provides insight of the concatenative confluence of language and situation. The formal structures (interrogative, negative, assertive, imperative etc.) and the levels of language (morphology , syntax , semantics and pragmatics) evolves stature of the text. The present study is a humble approach to decipher and analyse the amalgamation of the tenets of the abstract and the concrete concepts in the literary framework by Rabindranath Tagore. The selected text would be analyzed for its representation of temporal, spatial and social spaces and deictic centers and alternative possible worlds through the exclusive employment of language forms and functions and their ideological effects on the readers.
ETHOSOMES FOR DRUG DELIVERY OF NATURAL PRODUCTS IN DIABETES
Authors: Khatiwara Deepika , Sharma Bhaskar Jyoti , Hoque Ayoub , Deka Manoj Kumar
Published: June 2024

Diabetes mellitus (DM) is the most common metabolic disorder worldwide, brought on by either decreased pancreatic insulin secretion, diminished insulin action in the body, or both. Approximately about 200 million people are currently affected globally with diabetes. Over the past decades, advancements have been madefor the delivery of herbal products through novel approaches such as “Ethosomes”. Ethosomes are composed of phospholipid, alcohol, polyglycol and water. Due to their ease of surface modification, lack of immunogenicity, and ability to efficiently encapsulate both hydrophilic and lipophilic medicines, ethosomes may be a better alternative to liposomes for various therapeutic molecules, including natural products. The unique combination of phospholipids and ethanol in ethosomes provides a stable and biodegradable nanocarrier system that minimizes adverse effects and maintains the integrity of the skin barrier. Ethosomes have demonstrated significant potential for delivering a wide range of drugs, including small molecules, peptides, proteins, and even genetic materials. The purpose of this review is to outline ethosomes for delivery of natural product for Diabetes mellitus.
RADIOCHEMISTRY
Authors: Jain Shuchi , Gupta Dr. Ravikant , Jaiswal Pooja , Vengurlekar Dr. Sudha
Published: June 2024

"Radiochemistry" is the study of chemical transformations of radioactive substances, dealing with radioactive waste from nuclear power engineering, solving radioecology problems, developing methods for manufacturing sources of radioactive emissions, and isotope separation. "Radiation chemistry" is the study of chemical changes caused by ionizing radiation, as well as the research of radiation-chemical processes, the creation of methods for predicting the radiation resistance of various materials, and the development of ways for protecting them from destruction. Radiation chemistry is also responsible for the development of radiation-chemical methods for the synthesis of organic compounds and the production of modified materials for medicine, biotechnology, and membrane technology; the development of new radiation-resistant materials, the radiation modification of polymers; and the development of new radiation-resistant materials.
THE ROLE OF ANIMISM WITHIN CERTAIN INDIGENOUS TRIBES OF NORTH-EAST INDIA: A STUDY WITH SPECIAL REFERENCE TO THE RABHAS OF ASSAM
Authors: Bordoloi Nihar
Published: June 2024

The term 'Animism' was first propounded by anthropologist E.B. Taylor. Animism is the belief which regards that every entity of this world possesses a spiritual essence. This doctrine believes that everything on this planet such as plants, animals, rivers, stones, etc. are animated and alive. Most of the tribal communities of North East India are primitive and animistic in their outlook. For instance, the tribes of North East India such as Misings, Bodos, Garos, etc. believe that the whole world is endowed with spirits. Similarly, the Rabha tribe which is one of the most significant tribes of North East India also possesses an animistic perspective which can be discovered in their indigenous beliefs and practices. This paper attempts to highlight the animistic notion prevalent within the different indigenous beliefs of certain tribes of North East India with special reference to the Rabhas of Assam.
STUDYING THE STRENGTH CHARACTERISTICS OF SCC BY SUBSTITUTING METAKAOLIN FOR CEMENT AS WELL AS ADDING NANO SILICA
Authors: Kumar S M Naveen , Vijay Manu , Krishna R R Gagan , Prasad Devi
Published: June 2024

The use of self-compacting concrete (SCC) has increased significantly over the last few years, and extensive study and modification have been made to create self-compacting concrete with the appropriate properties. The use of treated and untreated industrial byproducts, household garbage, etc. as raw materials in concrete is currently popular throughout the world. These not only assist in recycling waste products but also improve the environment by being cleaner and greener. The use of metakaolin and nano-silica in SCC is the main topic of the current investigation. The steel bar corrodes when reinforced concrete is exposed to severe environments such chloride-bound air, which damages the concrete through its pore structure. The usage of pozzolanic materials, such as metakaolin (MK) and nano-silica (NS), can be utilised as a partial cement replacement material that enhances the mechanical, durability, and microstructure of concrete while also reducing the number of pores in it. Work was done on an experimental study of the flowability, passing ability, compressive strength, split tensile strength, and flexural strength of SCC in this project. In this study, metakaolin and nano-silica were used to partially replace cement in the creation of SCC. Five mixtures with varying amounts of nano-silica (0%, 0.5%, 1.0%, and 1.5%) and metakaolin (5%, 10%, 15%, and 20%) as a partial replacement for cement are taken into consideration. Workability and toughened tests are conducted for each combination, and the findings for hardened attributes are reported.
EFFECTS OF LOW-INTENSITY RESISTANCE TRAINING WITH BLOOD- FLOW RESTRICTION ON MUSCLE
Authors: Bano Bushra , Sundus Habiba , Khan Aatika , Varshney Akshita
Published: June 2024

Blood flow restriction (BFR) during low-intensity resistance training has recently drawn a lot of interest because of its potential to increase muscle strength and hypertrophy. Blood flow restriction (BFR) during low-intensity resistance training has recently drawn a lot of interest because of its potential to increase muscle strength and hypertrophy. The purpose of this study is to investigate the scientific evidence that exists about the effects of blood flow restriction combined with low-intensity resistance exercise on muscle physiology and performance. An explanation of the basic processes governing the BFR training approach, as well as its effects on muscle oxygenation, cellular metabolism, and hormone release, is given in the review's opening paragraph. In-depth analysis of the complex interactions between BFR and conventional resistance training is provided, emphasising how low-intensity loads combined with limited blood flow cause muscle stress and set off adaptive responses. In conclusion the present research shows that coupled with low-intensity resistance training and blood flow restriction can be a successful and secure method for enhancing muscle adaptations. However, further investigation is required to clarify the ideal procedures, long-term effects, and potential drawbacks of this training approach. Athletes, fitness enthusiasts, and rehabilitation specialists may eventually find it helpful to understand the underlying mechanics and practical applications of BFR training in order to improve training methods and achieve desired results.
COMPARATIVE STUDY ON EFFECT OF GARDEN CRESS SEEDS HEALTH DRINK AND “MIKRONUTRIENT SUPPLEMENTATION” ON MNC SCHOOL CHILDREN IN ANEMIA
Authors: Khan Farhana Mahreen Najeeb Ahemad Dr.
Published: June 2024

Anemia is one of the major public health problems that affect the world total population widely. Anemia is a condition characterised by reduction in the volume of red blood cells and a decrease in the haemoglobin concentration in blood. Garden cress seeds being the richest source of non-heme iron, helps to increase the haemoglobin levels. The objective of study is to study of effect of garden cress seeds to improve the status of iron in children of MNC school Aurangabad. The study was conducted on school going children group of 40 respondents (8-11years). The total 40 respondents were selected and divided into two groups such as 20 children in GPA (experimental group) and 20 children in GPB (placebo group), pre and post blood haemoglobin level was observed. The health drink which is developed with garden cress seeds was given to the GPA and Mikronutrient supplementation syrup given to GPB. The haemoglobin level of experimental group was compared with placebo group which are 12.18g/dl and 10.71g/dl respectively. Post experimental values were found more than pre experimental value. There was significantly increased haemoglobin level. The garden cress seeds health drink was found more effective in increasing the haemoglobin than Mikronutrient supplementation syrup in school going children. Garden cress seeds health drink help to increase the haemoglobin level, when taken regularly it help to reduce the risk of anemia in school going children.
VISCO ELASTIC BEHAVIOUR OF POLYMERS
Authors: Patil Shalini
Published: June 2024

In Polymeric materials mechanical properties exhibit two ideal special cases hence these are known as visco elastic materials. The property of stress is a function of strain and function of time for visco elastic material. The very common characteristic features of visco elastic materials are a time dependent strain response to a constant stress and a constant strain response to a time dependent stress. When the applied stress is less or zero to the materials, the material recovers slowly with a time. This type of effects also observed in metals at very high temperatures whereas in plastics they show this type of behaviour at room temperature.
HEALTH INFORMATICS: IMPROVING HEALTHCARE THROUGH DATA AND TECHNOLOGY
Authors: Sarankar Dr. Satish Kumar
Published: June 2024

In the dynamic landscape of modern healthcare, the intersection of technology and data has given rise to a transformative force known as Health Informatics. This chapter delves into the integral role played by Health Informatics in reshaping the healthcare industry. Defined as the bridge between technology and healthcare, this multidisciplinary field orchestrates the acquisition, storage, and utilization of health information in digital formats. Key components, such as Electronic Health Records (EHRs), Health Information Exchange (HIE), Clinical Decision Support Systems (CDSS), and Telemedicine, are explored in depth. The chapter underscores the significance of Health Informatics in fostering improved patient care, streamlined processes, and cost reduction through the efficient use of resources. It illuminates the pivotal role of data-driven insights, facilitated by health analytics and data mining, in enhancing decision-making processes and predicting disease outbreaks. Patient empowerment takes center stage, facilitated by digital health tools and portals that encourage individuals to actively manage their health. Additionally, the chapter discusses the critical components of Health Informatics, including Health Information Management and Healthcare Informatics Research, emphasizing their contribution to maintaining data accuracy, accessibility, and adherence to ethical standards. The importance of interoperability is highlighted, ensuring seamless communication and data exchange across diverse healthcare settings
MALARIA & DENGUE FEVER TOGETHER CURED BY HOMOEOPATHY - EVIDENCE BASED CASE
Authors: Chawla Dr. Anita Nanakram
Published: June 2024

Homoeopathy - Evidence Based Case
CONSERVATIVE MANAGEMENT FOR CONGENITAL SCOLIOSIS: A CASE REPORT
Authors: Kansara Dr. Viral , Tadvi Dr. Darshana
Published: June 2024

This is the case report of a 11-year-old girl diagnosed with Congenital Scoliosis thoraco-lumbar cobb’s angle 30°, conservatively managed as the parents were not in capacity to buy braces or have surgery. Intervention: She was treated conservatively with flexibility training, strength training, self-active correction exercises, habitual corrections, task oriented training and home exercise protocol and patient/parents education. Results: After 6 months of treatment there no change in cobb’s angle. But Posture, Muscle strength(MMT), and Range of motion(ROM) where showing significant change. Conclusion: The preferred treatment options for congenital scoliosis are generally braces and surgery. This case report has shown feasibility of Physiotherapy management in congenital scoliosis, with a newer approach like self-correction exercise with task oriented training focusing on her chief complain related to her daily functions & quality of life.
A NEW ERA OF CONNECTIVITY: EXPLORING THE POTENTIAL OF PI NETWORK
Authors: Shaikh Asmi , Shirsekar iddhesh Sushil , Guha Thakurta Arundhati
Published: June 2024

Pi Network is a decentralized and trust less network that was created to make cryptocurrency accessible to everyone, regardless of their technical knowledge or resources. Its unique economic model allows users to mine Pi cryptocurrency using their mobile phones, making mining more accessible and promoting decentralization. Pi Network has implemented a system of trust levels and nodes that reward active and engaged users, ensuring that the network remains secure and stable. The Pi Network offers low transaction fees, fast transaction speeds, and is resistant to hacks and cyber-attacks. Its energy-efficient consensus algorithm makes it less harmful to the environment, and its limited supply of 10 trillion helps prevent inflation. The Pi Network's innovative solutions to the challenges of traditional cryptocurrency mining, along with its low transaction fees and fast transaction speeds, make it an attractive payment and investment option for businesses and individuals looking to reduce their transaction costs and process high volumes of transactions quickly.
THE HIDDEN MEANING IN LAYOUT OF CASINOS
Authors: Mehta Khushi , Sushil Shirsekar Siddhesh , Guha Thakurta Arundhati
Published: June 2024

This paper is about the psychology behind the design of casinos. Many might not be aware that there are major psychological backings behind each element. The layout, lighting, colours, interior and music has been given vital importance. In the past few decades, casinos have been designed according to Bill Friedman’s approach. This method resulted in several problems. It also increased the stress level of the visitors. A solution was provided by Roger Thomas, an addict and designer named ‘The playground approach’. This paper gives insights about the details that go into planning and designing a casino.
MECHANISM OF COLLOIDAL COPPER/ COPPER OXIDE NANOPARTICLES MEDIATED BACTERICIDAL ACTIVITY AND ITS MULTI-DIMENSIONAL OUTLOOK IN FUTURE
Authors: Das Mou , Banik Milon
Published: June 2024

Copper oxide and colloidal copper nanoparticles have gained popularity as powerful antibacterial agents. These nanoparticles have recently shown promise in preventing the spread of antibiotic resistance, combating microbial diseases, and providing fresh approaches in a variety of fields. This thorough analysis explores the complex mechanisms behind the bactericidal action of copper oxide and colloidal copper nanoparticles, illuminating their multifaceted use and potential future uses. Due to their outstanding antibacterial qualities, colloidal copper and copper oxide nanoparticles have attracted a lot of attention in the domains of nanotechnology, materials science, and biomedicine. These nanoparticles have come to light as possible substitutes and additives in response to the growing concern over antibiotic resistance and the requirement for sustainable antibacterial solutions. The purpose of this review is to examine the multi-dimensional potential of copper oxide and colloidal copper nanoparticles in various applications and to clarify the mechanism underlying their bactericidal activity. Through mechanisms involving ROS production, cell membrane rupture, intracellular absorption, and antibacterial synergy, colloidal copper and copper oxide nanoparticles demonstrate strong bactericidal action. Their numerous uses include biomedicine, water filtration, food packaging, agriculture, and even possible antiviral properties. For their successful integration into diverse industries, it is essential to solve issues with biocompatibility, resistance, regulation, and scalability. These nanoparticles have the potential to revolutionise the fight against bacterial illnesses and contribute to a safer and more sustainable future with continued study and innovation.
RANKING THE FACTORS AFFECTING INDEPENDENT PROGRESS OF STARTUPS WHILE COLLABORATING WITH CORPORATES: A STUDY USING AHP
Authors: S R Sneha , Uthaman S Dr. Vijaya
Published: June 2024

Corporate venturing as a service is established by collaborating with Startups. In the contemporary era, the trend of collaboration between startups and corporates is gaining prominence, and corporate entities are more receptive than ever before to such partnerships. The purpose of this paper is to find out perspectives about the essentials to be kept aligned by startups while taking their sole role as corporate growth accelerators. For this study to evaluate the essential factors, an integrated multi-criteria decision-making technique Analytic Hierarchy Process is used. Industry experts were carefully chosen, and a questionnaire was utilized to gather data. The study aims to assess the key factors that startups need to align to foster their growth when collaborating with corporate entities. The primary focus of this study is to examine the collaborations between startups and corporates, and offer valuable insights to entrepreneurs, stakeholders in the startup ecosystem, and corporate professionals interested in cultivating and enhancing successful collaborative relationships.