bluuebunny/crossref_metadata_2025 huggingface dataset:
METROLOGICAL STUDY OF THE EFFECT OF TEMPERATURE ON THE DISSOCIATION OF ACETIC ACID
Authors: Mygushchenko Ruslan , Volobuyev Maksym , Asieieva Iryna , Kropachek Olga , Baliev Volodymyr
Published: April 2024

This article is devoted to the study of the dissociation reaction of acetic acid at a temperature change in the range from room (20 °C) to 75 °C. In the course of research, the methods were considered, the classification of the considered methods was carried out, and the methodology of the experiments was formulated. The selected technique reflects the express measurement of the hydrogen pH indicator using a portable pH-meter. Experiments were carried out in laboratory conditions – Lincoln Park, Chicago, USA. Acetic acid with a concentration of 6 mol/l was chosen as the basis. By adding a distilled water, a base concentration of 1 mol/l was obtained. Nodal temperature points were selected for measurements (four points in the temperature range of 20 °C – 75 °C); five experimental samples of acetic acid (1 mol/l) were formed; the analysis of the measurement results at nodal points was carried out for the accuracy of the measurement results of five test samples of acetic acid using first- and second-order statistical moments (mathematical expectation and variance); accuracy characteristics of experimental data (instrumental and methodical errors) were estimated. Research samples (acetic acid samples) were brought to the nodal points with a positive temperature gradient using a steam bath. The measurement error estimate was determined by the accuracy class of the device and was 0.1%. The obtained pH values were converted to the number of hydrogen cations, followed by the determination of the degree of dissociation and the dissociation constant. These determinations were carried out under the condition of ensuring chemical equilibrium. The nature of the behavior of the degree and constant of dissociation when the temperature of the test samples changes is clearly non-linear. In the course of research, the main measurement errors were established, the main of which is the nonlinearity of the transformation. Quantitative values of nonlinearity errors were determined by the method of measurements with multiple observations using the Student's correction factor. The article provides conclusions based on the results of research and presents the prospects for temperature correction of pH-meters to eliminate the temperature component of the error of pH-meters.
FEATURES OF THE FILM FLOW OF A LIQUID OVER A VERTICAL SURFACE IN A TRANSVERSE MAGNETIC FIELD
Authors: Mamedov Asiman , Stas Serhiy , Lavrukhin Evhen
Published: April 2024

One of the actual problems of magnetohydrodynamics is the problem of the flow of electrically conductive liquids in thin liquid layers in the presence of a transverse magnetic field. Unfortunately, studies of these problems have not been sufficient so far. The influence of a transverse magnetic field can affect a number of factors: the change in the viscosity of the flow due to the magnetic field on the physico-chemical characteristics of the medium; manifestation of the effect of flow deceleration, which can have a significant effect on the hydrodynamic characteristics of the film flow in the processes of heat and mass transfer. In this regard, in this work was made an attempt to consider the influence of a constant magnetic field on the formation of a thin liquid layer on a vertical surface under the action of ponderomotive forces. As known, ponderomotive forces in the case under consideration can lead to a number of effects associated with a change in viscosity and flow deceleration. To a greater extent, this can manifest itself in thin liquid layers, depending on the ratio of gravitational forces, inertia forces and forces of a magnetic nature. An analysis of the influence of this phenomenon in the considered case of thin liquid layers, as shown in the work, significantly affects the length of the hydrodynamic initial section, the thickness of the liquid layer, and the damping of wave motion in the zone of stabilized flow. Recommendations for calculating these characteristics are presented in this article, in which much attention is paid to the definition of the liquid layer, depending on the ratio between the forces of inertia and the forces of a magnetic nature. An expression was also obtained for determining the distribution of velocities in the zone of a stabilized film flow in a transverse magnetic field. Thus, by comparing the expression for determining the distribution of velocities in a film without the influence of a magnetic field with the expression in the presence of a magnetic field, one can estimate the effect of ponderomotive forces on the flow of a liquid film.
MATHEMATICAL MODEL THE MAIN DISTRIBUTOR OF THE HYDRAULIC TURBINE SPEED CONTROL SYSTEM
Authors: Cherkashenko Mikhaylo , Hasiuk Oleksandr
Published: April 2024

MATHEMATICAL MODEL THE MAIN DISTRIBUTOR OF THE HYDRAULIC TURBINE SPEED CONTROL SYSTEM
ENERGY RESISTANCE OF MEDICAL FACILITIES DURING TRANSIENT OPERATION MODES OF THE ENERGY SYSTEM
Authors: Grib Oleg , Karpaliuk Igor , Donetska Tetiana , Dehtiar Yaroslav , Pyshnyi Oleksandr
Published: April 2024

The question of increasing the reliability of the operation of objects in the energy system of Ukraine is under consideration. It is shown that the issue of energy supply of public facilities received new requirements during the war. Especially such requirements now apply to medical facilities. The main types of energy for medical institutions are the supply of electrical and thermal energy. For Ukraine, on the basis of climatic features, the consumption of thermal energy is much larger than that of other types of energy. Therefore, one of the important steps to reduce energy consumption is thermal modernization of buildings. This paper considers the general energy supply system, which includes not only heat supply but also electricity supply. It is necessary not only to have the electricity itself in the network, but also to meet the quality requirements. Medical electrotechnical complexes are one of the most critical to the quality of electrical energy. Correct diagnosis and maintenance of vital activity of the patient's organism depend on their work. It is proposed to assess the state of energy supply through the model of mutual dependence of energies. Therefore, qualitative changes in thermal energy indicators cannot be compensated for by network solutions. Maintaining the temperature in the premises is possible precisely due to the use of other heat sources. In terms of the energy connectivity model, the only way to equalize the "body of energy consumption" is the mutual replacement of one energy by another. Variants of equalization of the "body of energy consumption" for medical institutions are defined. A presentation of the "body of energy consumption" is proposed, with a reflection of the qualitative limits of the shape of the "body of energy consumption" in relation to thermal energy. The concept of the limit of energy sustainability according to qualitative indicators is introduced. A number of measures to support energy sustainability have been identified. In order to achieve the longest compliance with energy supply quality indicators, it is proposed to disconnect part of the premises from the energy supply system while preserving the energy supply group for those premises that will remain. It is noted that using the criterion of energy sustainability, it is possible to analyze construction structures and technological processes in the buildings themselves in order to develop measures to increase energy sustainability with a given direction.
STUDY OF THE CURRENT STATE OF DEVELOPMENT OF CONTROL AND AUTOMATION SYSTEMS OF HYDRAULIC MACHINES
Authors: Yaroshenko Oleksii , Hasiuk Oleksandr
Published: April 2024

Future hydraulic systems will heavily incorporate AI and ML, enhancing control precision and enabling predictive maintenance. AI-driven algorithms will increasingly be used for predictive maintenance, improving the reliability and lifespan of hydraulic systems. This integration will lead to smarter, more efficient operation, and extended equipment lifespans. The integration of IoT technology is crucial for real-time data collection and analysis, facilitating remote monitoring and control that leads to improved operational efficiency and maintenance management. The use of cloud platforms for data analysis and storage is likely to increase, enabling more sophisticated data processing and accessibility. Advanced sensors and predictive maintenance contribute significantly to safety by anticipating system failures. Reliability is also enhanced through reduced downtime and smarter maintenance schedules. The growing convergence of advanced robotics with hydraulic systems is steering these systems towards increased autonomy. Enhanced safety features will be a priority, driven by smarter sensors and control algorithms. The growing complexity of hydraulic systems underscores the need for specialized training and education in system design, maintenance, and operation. Future hydraulic machines are expected to be more customizable and flexible, with modular designs that cater to specific industry needs. A significant challenge is the adaptability of AI and ML models in dynamic, real-world conditions. Continuous learning methods are being developed to address this. In summary, the future of hydraulic machine control systems and automation looks towards greater intelligence, connectivity, efficiency, and adaptability. These trends will be underpinned by ongoing technological advancements, particularly in AI, ML, IoT, and sustainable practices.
Hip Osteoarthritis in Patients Undergoing Surgery for Severe Adult Spinal Deformity
Authors: Diebo Bassel G. , Alsoof Daniel , Balmaceno-Criss Mariah , Daher Mohammad , Lafage Renaud , Passias Peter G. , Ames Christopher P. , Shaffrey Christopher I. , Burton Douglas C. , Deviren Vedat , Line Breton G. , Soroceanu Alex , Hamilton D. Kojo , Klineberg Eric O. , Mundis Gregory M. , Kim Han Jo , Gum Jeffrey L. , Smith Justin S. , Uribe Juan S. , Kebaish Khaled M. , Gupta Munish C. , Nunley Pierce D. , Eastlack Robert K. , Hostin Richard , Protopsaltis Themistocles S. , Lenke Lawrence G. , Hart Robert A. , Schwab Frank J. , Bess Shay , Lafage Virginie , Daniels Alan H. ,   International Spine Study Group
Published: April 2024

Background:

Hip osteoarthritis (OA) is common in patients with adult spinal deformity (ASD). Limited data exist on the prevalence of hip OA in patients with ASD, or on its impact on baseline and postoperative alignment and patient-reported outcome measures (PROMs). Therefore, this paper will assess the prevalence and impact of hip OA on alignment and PROMs.

Methods:

Patients with ASD who underwent L1-pelvis or longer fusions were included. Two independent reviewers graded hip OA with the Kellgren-Lawrence (KL) classification and stratified it by severity into non-severe (KL grade 1 or 2) and severe (KL grade 3 or 4). Radiographic parameters and PROMs were compared among 3 patient groups: Hip-Spine (hip KL grade 3 or 4 bilaterally), Unilateral (UL)-Hip (hip KL grade 3 or 4 unilaterally), or Spine (hip KL grade 1 or 2 bilaterally).

Results:

Of 520 patients with ASD who met inclusion criteria for an OA prevalence analysis, 34% (177 of 520) had severe bilateral hip OA and unilateral or bilateral hip arthroplasty had been performed in 8.7% (45 of 520). A subset of 165 patients had all data components and were examined: 68 Hip-Spine, 32 UL-Hip, and 65 Spine. Hip-Spine patients were older (67.9 ± 9.5 years, versus 59.6 ± 10.1 years for Spine and 65.8 ± 7.5 years for UL-Hip; p < 0.001) and had a higher frailty index (4.3 ± 2.6, versus 2.7 ± 2.0 for UL-Hip and 2.9 ± 2.0 for Spine; p < 0.001). At 1 year, the groups had similar lumbar lordosis, yet the Hip-Spine patients had a worse sagittal vertebral axis (SVA) measurement (45.9 ± 45.5 mm, versus 25.1 ± 37.1 mm for UL-Hip and 19.0 ± 39.3 mm for Spine; p = 0.001). Hip-Spine patients also had worse Veterans RAND-12 Physical Component Summary scores at baseline (25.7 ± 9.3, versus 28.7 ± 9.8 for UL-Hip and 31.3 ± 10.5 for Spine; p = 0.005) and 1 year postoperatively (34.5 ± 11.4, versus 40.3 ± 10.4 for UL-Hip and 40.1 ± 10.9 for Spine; p = 0.006).

Conclusions:

This study of operatively treated ASD revealed that 1 in 3 patients had severe hip OA bilaterally. Such patients with severe bilateral hip OA had worse baseline SVA and PROMs that persisted 1 year following ASD surgery, despite correction of lordosis.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
PENGEMBANGAN APLIKASI MOBILE FORUM DISKUSI MAHASISWA UNIVERSITAS PARAMADINA BERBASIS OBJEK
Authors: Putra Muhammad Daffa Arviano , Darwis Muhammad , Hendrowati Retno
Published: April 2024

Forum adalah suatu wadah untuk bertukar informasi dan pemikiran. Dalam era digital, informasi merupakan hal yang paling berharga dan forum menjadi sarana tepat untuk mendapatkan informasi. Akibatnya, forum saat ini juga hadir dalam bentuk aplikasi. Suatu aplikasi forum dapat memberikan banyak manfaat bagi penggunanya. Pada penelitian ini, dirancang aplikasi forum khusus mahasiswa Universitas Paramadina berbentuk mobile. Kehadiran aplikasi forum mahasiswa ini diharapkan meningkatkan kolaborasi dan semangat diskusi di antara mahasiswa, sehingga memperkaya pengalaman belajar mahasiswa di Universitas Paramadina. Proses pengembangan sistem aplikasi forum dilakukan dengan menerapkan konsep perancangan berbasis objek. Konsep ini diterapkan dengan pembuatan model-model diagram Unified Modeling Language (UML). Dengan demikian, rancangan sistem yang dibuat mengikuti struktur yang efisien dan mengikuti standard. Hasil rancangan kemudian diimplementasikan dalam bentuk prototype dengan memanfaatkan framework Flutter dan dilakukan pengujian secara menyeluruh untuk memastikan ketepatan dan kegunaan aplikasi dengan menggunakan metode blackbox dan whitebox. Hasil pengujian tersebut menunjukkan bahwa aplikasi forum tersebut telah berfungsi dengan baik.
Penerapan Metode Association Rule Dan Algoritma Apriori Untuk Analisis Pola Frekuensi Tinggi Prediksi Curah Hujan Di Kota Tegal
Authors: Gunawan  , Andriani Wresti , Hidayatullah Fikri Zain
Published: April 2024

Curah hujan merupakan salah satu faktor yang sangat penting dalam kehidupan sehari-hari, terutama di dalam bidang pertanian dan pengelolaan sumber daya air. Prediksi curah hujan yang akurat sangat dibutuhkan untuk mengurangi dampak yang ditimbulkan oleh banjir, kekeringan, dan kekurangan air. Tujuan penelitian ini adalah untuk memprediksi hujan di Kota Tegal menggunakan data curah hujan, suhu, kelembaban, dan tekanan udara. Association rule mining untuk identifikasi hubungan antar item guna memprediksi cuaca. Data tersebut kemudian diolah menggunakan algoritma Apriori untuk menemukan pola-pola asosiasi antar variabel dalam data. Hasil dari penelitian menunjukkan bahwa algoritma Apriori bisa digunakan untuk menemukan pola asosiasi yang dapat digunakan untuk memprediksi hujan di Kota Tegal. Berdasarkan hasil dari penelitian dan pembahasan yang telah dilakukan ini, bisa disimpulkan bahwa metode Association Rule menggunakan algoritma Apriori bisa diterapkan dalam simulasi prediksi hujan di Kota Tegal dengan cukup baik. Berdasarkan analisis, ditemukan beberapa aturan asosiatif yang memiliki nilai lift ratio lebih besar dari 1, sehingga dapat dikatakan bahwa aturan tersebut bersifat sangat kuat dan valid untuk digunakan sebagai acuan dalam memprediksi hujan. Metode ini dapat membantu dalam memperkirakan kondisi cuaca dan memberikan informasi yang berguna untuk masyarakat maupun pihak berwenang dalam mengambil keputusan terkait kegiatan di luar ruangan
IMPLEMENTASI ALGORITMA NAIVE BAYES CLASSIFIER MENGGUNAKAN FEATURE FORWARD SELECTION DALAM MEMPREDIKSI KETEPATAN MASA STUDI MAHASISWA
Authors: Noliza  Safitri
Published: April 2024

Students are one of the important pillars in the life cycle of a higher education institution. One indicator of the success of a study program can be seen from the accuracy of the student's study period. The accuracy of a student's study period refers to the time schedule that the student must achieve from entering the study program to graduating, according to the time span determined by the university. At the Diploma Three (D-III) level, it is said to graduate on time if you have completed the equivalent of three academic years of study and not graduate on time if you have completed more than three academic years. Study. This research aims to influence the quality of study programs, so that it is used as an assessment criterion for accreditation by (BAN-PT). The results of this research are presented in accordance with the research conducted. The data used in this research is academic data for students of the Informatics Management Study Program (D-III) Class 2020 – 2022. The categories used are gender, major, IPS 1 to IPS 4, credits, and GPA. The test results using 129 training data and 40 test data obtained an accuracy of 97.50% using the Naive Bayes method with forward selection. There were 12 students who made late predictions and 28 students made correct predictions. So it can be stated that the Naive Bayes process model is suitable for use in determining good decision results in terms of prediction and classification.
Analisis Pengaruh Probabilitas Crossover Terhadap Kinerja Algoritma Genetika Dalam Optimasi Penjadwalan Matakuliah
Authors: Salman Rudi , Suprapto  , Irfandi
Published: April 2024

Kecepatan kinerja Algoritma Genetika (AG) ditentukan oleh waktu komputasi. Waktu komputasi dalam AG untuk pencarian nilai optimum sangat dipengaruhi oleh parameter-parameter : ukuran populasi (popsize), Probabilitas Crossover (Pc), Probabilitas Mutasi (Pm) dan metode seleksi yang dipilih.  Pc merupakan salah satu parameter penting dalam AG. Suatu kromosom yang akan mencapai solusi terbaik dapat diperoleh dari proses Crossover (pindah silang) dua kromosom induk. Proses Crossover sangat dipengaruhi oleh nilai Pc. Penentuan nilai Pc yang sesuai dan tepat merupakan indikator, seberapa besar kromosom induk yang akan mengalami crossover.   Metode yang digunakan untuk Analisis Pengaruh Pc terhadap kinerja AG dengan cara mengganti nilai Pc antara 0,80-0,95. Simulasi dilakukan menggunakan MATLAB R2012b sehingga diperoleh waktu komputasi terbaik untuk setiap nilai Pc yang dipilih. Sementara parameter-parameter AG yang lain tetap,yaitu :  Pm=0,05 dan ukuran populasi=100 untuk setiap pergantian nilai Pc. Hasil pengujian menggunakan MATLABR2012b menunjukkan bahwa waktu komputasi tercepat berada pada rentang nilai Pc antara 0,85-0,95 dengan rata-rata waktu komputasi 0,14564s.  Hal ini menunjukkan bahwa untuk kasus optimasi penjadwalan matakuliah diprodi TE Unimed nilai Pc antara 0,85-0,95, akan memberikan waktu komputasi tercepat.
IMPLEMENTASI METODE TREND MOMENT UNTUK PREDIKSI PENJUALAN (STUDI KASUS DI TOKO ZACOZI PANCING KABUPATEN SOLOK)
Authors: Fauziyyah Atika
Published: April 2024

Zacozi Fishing Shop is a shop that sells various kinds of fishing equipment, from small to large. Through direct research at the Zacozi Pancing Shop, the problem was found that from year to year sales of fishing equipment at this shop experienced an erratic increase and decrease in sales every month. This happens because many goods are not sold out and there are many goods that consumers need but the stock of goods requested by consumers is insufficient. This is also because the shop does not have a system that can predict sales, so many products are not available for a long time. Therefore, it is necessary to have a sales prediction information system using the Trend Moment method to be able to predict sales of goods in the following month. The data used is fishing rod sales data from June 2022 to June 2023. With a sales prediction system using the Trend Moment method which can produce sales predictions for goods at the Zacozi Pancing Shop with an average success rate of 90%, it can help the shop in picking Actions that should be taken, especially in controlling product availability using the Trend Moment method so that stock shortages and excesses can be avoided.
PENGEMBANGAN APLIKASI DKM REGISTRATION SYSTEM BERBASIS WEB MENGGUNAKAN METODE WATERFALL
Authors: Muhamad Adillah Fatih  , Reza Arif Maulana  , Rizki Reza Pratama  , Muhammad Darwis  , Retno Hendrowati
Published: April 2024

Dewan Keluarga Masjid Universitas Paramadina (DKM Paramadina) merupakan organisasi mahasiswa yang aktif dalam aspek sosial dan keagamaan. DKM Paramadina rutin mengadakan berbagai acara atau kegiatan seperti acara Maulid Nabi Muhammad, Qurban, hingga Festival Keagamaan. Salah satu permasalahan yang sering dihadapi oleh DKM Paramadina adalah data registrasi dan absensi tidak sinkron, sehingga sulit untuk memastikan peserta yang berhak mendapatkan benefit acara. Untuk mengatasi masalah tersebut, DKM Paramadina membutuhkan sistem registrasi dan absensi yang efisien. Tujuan dari studi ini adalah memperbaiki dan mengembangkan sistem pendaftaran dan pencatatan kehadiran acara dengan menggunakan pendekatan Metode Waterfall. Hasil penelitian ini adalah DKM Registration System berbasis web, yang memungkinkan penggunaan pencatatan dan pemantauan kehadiran peserta acara secara efisien. Sistem ini memanfaatkan Framework Next.js untuk Frontend, Express.js untuk Backend, dan Node.js sebagai runtime. Untuk menyimpan data registrasi dan absensi, sistem ini terintegrasi dengan Google Spreadsheet dengan memanfaatkan Google API. Selain itu, Node Mailer juga digunakan untuk mengirimkan QR Code ke email pendaftar untuk absensi. Metode Blackbox telah digunakan untuk menguji keefektifan DKM Registration System dan hasilnya menunjukkan kinerja yang baik. Penelitian ini memberikan solusi efektif dan efisien dalam mengatasi permasalahan konvensional yang dihadapi oleh DKM Paramadina dalam manajemen acara.
Integrated Analysis of Water Quality in Treatment Plants: Physicochemical and Biological Assessments
Authors: Pratama Aditya Yoga , Marodiyah Inggit
Published: April 2024

Water treatment plants (WTPs) play a crucial role in ensuring access to safe drinking water, essential for human health and well-being. This study focuses on the IPA Kedunguling, operated by the Regional Drinking Water Company Sidoarjo, which serves the residents of Sidoarjo city. The objective was to evaluate the water treatment process and quality using physical, chemical, and biological assessments in accordance with Ministry of Health Regulation No. 2/2023 and Government Regulation No. 66/2014. The process involves raw water intake at the Intake, followed by treatment at the WTP and distribution to residents. Laboratory tests revealed that chemical and biological parameters met regulatory standards; however, Total Dissolved Solid (TDS) levels exceeded permissible limits, highlighting a potential area for improvement. This study underscores the importance of continuous monitoring and optimization of water treatment processes to ensure the provision of safe drinking water to communities.
Highlights :

Water treatment plants ensure access to safe drinking water, vital for human health.
Evaluation of IPA Kedunguling's water treatment process and quality according to regulatory standards.
Laboratory tests identify areas for improvement, particularly in Total Dissolved Solid levels.

Keywords: Water treatment plants, water quality assessment, regulatory compliance, drinking water safety, continuous monitoring.
LA DEFENSA DE LA LIBERTAD DE ESTABLECIMIENTO DE LAS EMPRESAS EUROPEAS EN TIEMPOS DE CRISIS A TRAVÉS DE LAS MODIFICACIONES ESTRUCTURALES TRANSFRONTERIZAS INTRACOMUNITARIAS.
Authors: Soler Samper Carlos
Published: April 2024

En el presente trabajo analizaremos la importancia de atender a la regulación concerniente a la movilidad de las empresas dentro de la Unión Europea. Esta movilidad debe ser atendida desde una perspectiva instrumental en la medida en la que la misma puede suponer una herramienta de la que valernos en situaciones de crisis, tal y como en la que nos encontramos actualmente. La razón de ser de este análisis reside en la existencia de la Directiva (UE) 2019/2121 y en su reciente transposición a la legislación nacional española a través del Real Decreto-ley 5/2023. Con todo ello, estudiaremos cómo un adecuado marco normativo en materia de modificaciones estructurales transfronterizas intraeuropeas puede derivar en la defensa de uno de los principales valores comunitarios: la libertad de establecimiento reconocida en el Tratado de Funcionamiento de la Unión Europea.
Surgical Options for Bertolotti Syndrome
Authors: Ahn Yo Han , Seo Jong Hun , Ju Chang Il , Kim Pius
Published: April 2024

This article provides a comprehensive examination of Bertolotti syndrome (BS), a disorder characterized by back pain due to a lumbosacral transitional vertebra, to facilitate surgical decision-making by exploring various surgical options, including the innovative approach of endoscopic spine surgery. A review of existing literature and studies on BS published until December 2023 was undertaken, utilizing databases such as PubMed and Google Scholar to identify relevant information. The review offers an integrated overview of the essential knowledge of BS and a comprehensive range of surgical treatments. Symptomatic BS can manifest as pain originating from pseudoarticulation and the facet joints, discs, adjacent segments, and the L5 root, indicating a diverse distribution of pain sources. Furthermore, various surgical strategies are tailored to the specific origin of pain, including pseudoarticulation resection, transverse processectomy, decompression, nerve root decompression, fusion, and endoscopic spine surgery. For individuals with BS contemplating surgical solutions, performing a detailed assessment of symptoms and physical evaluations is imperative to accurately identify the origin of the pain. The choice of a surgical strategy must be meticulously customized according to the identified source of pain, guaranteeing a tailored and efficacious treatment for each patient.
Comprehensive analysis of predictive significance of PRR11 in glioma at multiple-datasets and single-cell sequencing levels
Authors: Han Wei , Chen Liang
Published: April 2024

Purpose Glioma, characterized with invasive growth and high recurrence, is the main cause of brain-tumor-related deaths. Currently, PRR11 has exhibited its predictive value in diagnosis, prognosis and immunotherapy of several human cancers. However, the predictive significance of PRR11 in glioma is still uncertain.
Methods Glioma-related information from multiple-datasets and single-cell sequencing (scRNA-seq), including CGGA, TCGA_GTEx, GEO, 10x Genomics and Smart-seq, was included in this study. Then, clinical correlation analysis, univariate and multivariate Cox analysis, Kaplan–Meier survival analysis and ROC curve analysis were utilized to validate diagnostic and prognostic value of PRR11 in glioma. Besides, functional mechanisms of PRR11 in glioma were also explored via Spearman correlation, immune infiltration, scRNA-seq, GO enrichment and KEGG analysis.
Results PRR11 is a promising and reliable predictor in diagnosis and prognosis of glioma patients, positively correlates with clinical malignancy, World Health Organization (WHO) grades, IDH mutation status, 1p19q codeletion status, histology and poor survival time. Mechanically, PRR11 is specifically overexpressed in Mano/Macro_C21 and CD8Tex cells and interferes with cell-cycle, transcription factors, immune infiltration, MYC targets and PI3K/AKT/mTOR signaling. Further exploration of biological mechanisms of PRR11 in glioma patients reveals that PRR11 might exert its oncogenic effects via involvement with chromosome segregation, coenzyme binding, cell cycle and pyruvate metabolism.
Conclusions Our results suggest that PRR11 might be a novel and reliable diagnostic and prognostic predictor in glioma patients, providing a promising clinical therapeutic target for glioma.
Experimental Investigation of Thermal Runaway in 40Ah Prismatic Lithium Batteries at Different SOC
Authors: Wei Ningning
Published: April 2024

With the evolution of energy storage, Thermal Runaway (TR) stands out as the most critical safety concern for Lithium-Ion Batteries (LIBs). This study employs a prismatic lithium battery with a nominal capacity of 40Ah, featuring Li(Ni0.6Co0.2Mn0.2)O2 as the cathode material. The investigation delves into the thermal runaway characteristics of the battery at 25%, 50%, 75%, and 100% State of Charge (SOC) in a nitrogen environment. The findings indicate: 1) an ascending trend in the highest temperatures at various points within the battery as SOC increases, accompanied by a declining trend in normalized gas production and a non-linear relationship between the heat released during TR and the stored electrochemical energy; 2) the highest temperature point withinthe battery consistently resides at the surface, offering insights for the temperature monitoring of the Battery Thermal Management System (BTMS); 3) a direct correlation between higher SOC and increased material ejection, with a mass loss rate of 25.8% at 100% SOC, a static total gas production of 2.45 mol, and a maximum explosion index of 0.2886 kPa⋅m⋅s⁻¹.(Be accepted by a journal)
Efficacy and Safety of PCA-assisted Continuous Paravertebral Block in Subacute Herpes Zoster-associated Pain: Study Protocol for a Randomized, Controlled, Double-blind Superiority Trial
Authors: Yang Bo , Shi Xiaohan , Xu Yanan , Wang Qing , Meng Zhaojun , Lv Lin , Xu Jin , Qi Jing , Lu Yan , Dong Hailong , Gu Nan
Published: April 2024

Background
Pain management for herpes zoster-associated pain (ZAP) is essential to improve patients’ daily lives and potentially intervene in the chronicity. Long-lasting, repetitive painful stimuli might lead to central sensitization and neuropathic pain generation. The subacute phase is the main period for ZAP patients to seek medical attention, and it is also a critical treatment time window for the transformation of ZAP to chronic pathological changes. Although there is still a lack of rigorous considerable sample evidence, the pain degree of ZAP and the incidence of postherpetic neuralgia (PHN) may decrease accordingly with increasing adequate analgesia. Compared to repeated paravertebral nerve block (PVB), Patient-controlled analgesia (PCA) -assisted continuous PVB provides more prolonged and comprehensive pain relief according to patient needs. Given this, we intend to test the hypothesis that PCA-assisted continuous PVB delivers a safe and better analgesic effect and reduces PHN incidence in subacute ZAP patients.
Methods
A total of 82 eligible subacute herpes zoster (SHZ) patients will be recruited and randomly assigned to the PCA-assisted continuous PVB group (Group PCA) and the repeated PVB group (Group rPVB) at a 1:1 ratio. All enrolled patients will undergo thoracic paravertebral space (TPVS) catheterization and receive similar doses of medication for seven days. The main intervention factor lies in the different drug administration manners. PCA-assisted continuous PVB treatment will be achieved by pumping, while repeated PVB treatment will be conducted by injecting other therapeutic solutions. The participants and investigators will be both blinded to group allocation. The primary outcome is the VAS scores one month after treatment. The secondary outcomes include the incidence of PHN and the adverse events during treatment and follow-up.
Discussion
The results from this study will provide clinical evidence on the efficacy and safety of PCA-assisted continuous PVB for subacute ZAP patients.
Trial registration
Chinese Clinical Trial Registry: ChiCTR2300068158. Registered on 9 February 2023. https://www.chictr.org.cn/searchproj.html
Monitoring corn stover processing by the fungus Ustilago maydis
Authors: Robertz Stefan , Philipp Magnus , Schipper Kerstin , Richter Paul , Miebach Katharina , Magnus Jorgen , Pauly Markus , Ramírez Vicente
Published: April 2024

Background
A key aspect of sustainable bioeconomy is the recirculation of renewable, agricultural waste streams as substrates for microbial production of high-value compounds. One interesting approach is the bioconversion of corn stover, an abundant maize crop byproduct using the fungus Ustilago maydis. U. maydis is already used as a unicellular biocatalyst in the production of several industrially-relevant compounds. As a natural maize pathogen, the fungus is adapted to feed on nutrients derived from maize biomass. Here, we describe a small-scale bioreactor platform to investigate U. maydis processing of corn stover, combining online monitoring of fungal growth and metabolic activity profiles with biochemical analyses of the post-fermentation residue.
Results
By establishing and applying the online measuremet of important process parameters including scattered light, Gfp fluorescence, oxygen transfer rate and pH together with post-fermentation residue analysis we demonstrated that U. maydis utilizes specific carbohydrate sources within corn stover. More specifically, our findings reveal that it primarily grows by metabolizing soluble sugars, with only limited exploitation of the abundant lignocellulosics. The use of a lignin-deficient maize mutant, as well as the partial digestion of the lignocellulosic biomass with a commercial enzyme mixture, result in significant fungal performance enhancement, up to + 120%, likely as a result of the increased availability of specific lignocellulosic components. Furthermore, successful application of the established screening platform for the performance assessment of different engineered fungal strains was shown.
Conclusions
U. maydis can metabolize corn stover material as sole carbon source and the developed microtiter plate bioreactor platform enables quantification of the growth performance, as well as identification of the carbohydrate sources digested by the fungus. It serves as a first step for the process scale-up towards production of sustainable compounds from corn stover by U. maydis, and as a foundation for tailored carbohydrate active enzyme engineering in this fungus.
Effectiveness and mechanism of microbial dust suppressant on coal dust with different metamorphosis degree
Authors: Zhao Yanyun , Li Suning , Wu Mingyue , Hu Xiangming , Guo Yongxiang , Wang Jingqian
Published: April 2024

The extraction of coal from open-pit mines significantly contributes to environmental degradation, posing grave risks to human health and the operational stability of machinery. In this milieu, microbial dust suppressants leveraging Microbially Induced Carbonate Precipitation (MICP) demonstrate substantial potential for application. This manuscript undertakes an exploration of the dust mitigation efficiency, consolidation attributes, and the fundamental mechanisms of microbial dust suppressants across coal dust samples with varying metamorphic gradations. Empirical observations indicate that, in resistance tests against wind and rain, lignite coal underwent mass losses of 7.43 g·m-2·min-1 and 98.62 g·m-2·min-1, respectively. The production of consolidating agents within the lignite dust, attributable to the microbial suppressants, was measured at 0.15 g per unit mass, a value 1.25 and 1.07 times greater than that observed in bituminous coal and anthracite, respectively. Scanning Electron Microscopy coupled with X-ray Energy Dispersive Spectroscopy (SEM-EDS) and X-ray Diffraction (XRD) analyses illuminated that the consolidating products within the coal dust predominantly constituted calcite and vaterite forms of calcium carbonate. The consolidation mechanism of coal dust via microbial suppressants is articulated as follows: Subsequent to the application on coal dust, the suppressants induce the formation of carbonate precipitates with inherent adhesive properties. These carbonates affix to the surfaces of coal dust particles, progressively encapsulating them. Furthermore, they play a pivotal role in bridging and filling the interstices between adjacent dust particles, thereby culminating in the genesis of a dense, cohesive mass capable of withstanding erosive forces.
Impact of a mindfulness-based intervention on well-being and mental health of elementary school children: Results from a randomized cluster trial
Authors: Malboeuf-Hurtubise Catherine , Taylor Geneviève , Lambert Danika , Paradis Pierre-Olivier , Léger-Goodes Terra , Mageau Geneviève A. , Labbé Gabrielle , Smith Jonathan , Joussemet Mireille
Published: April 2024

Background: Prevention programs for children such as mindfulness-based interventions (MBIs) are often implemented in schools to prevent psychological disorders from emerging and contribute to children’ mental health.
Aim: This study used a randomized cluster design and assessed the impact of a MBI on well-being and mental health of elementary school children’s.
Method: 13 elementary school classrooms were randomly allocated to the experimental condition (7 classrooms, n = 127 students) or the waitlist control condition (6 classrooms, n = 104 students). Participants in the experimental condition received a 10-week MBI.
Results: Regression analyses revealed significant differences between conditions for inattention. Participants in the MBI condition reported no changes in pre- to post-intervention scores, whereas participants from the control conditionreported increases in scores. Results also showed significant differences in competence scores. Participants in the MBI condition reported a non-significant decrease in competence scores, whereas participants in the control condition reported significantly higher competence scores from pre- to post-intervention.
Discussion: Results do not indicate that the MBI had a significant impact on children’s well-being and mental health. This suggests MBIs may not have an added value when compared to other preventive interventions geared towards well-being and mental health promotion in school settings.
A parasitic leiomyoma of the greater omentum disguised as an abdominal tumor：a case report and literature review
Authors: Xie Jiping , Li Wu , Zhu Guang , Liu Yanbo , Jin Linxi , Chen Linlin
Published: April 2024

Parasitic leiomyoma (PL) is an exceedingly rare type of leiomyoma characterized by the distribution of multiple nodules across various organ surfaces within the pelvic and abdominal cavities, mimicking malignant tumor implants. PLs originating from the greater omentum are notably rare, with few cases reported thus far. Their nonspecific clinical presentations, such as abdominal distension, ascites, and urinary difficulties, often lead to their misidentification as abdominal malignancies. The considerable mobility of the greater omentum facilitates PL torsion, potentially causing ischemic necrosis of the tumor mass and presenting as acute abdomen, which complicates diagnosis further. Clinicians should consider the possibility of PLs of the greater omentum in patients with a history of uterine fibroids or prior fibroid surgeries. This review highlights a case of a patient who experienced sudden onset abdominal pain eight years after undergoing laparoscopic myomectomy. Intraoperative findings confirmed torsion and necrosis of a PL on the greater omentum, leading to the surgical removal being deemed the most suitable treatment method.
Faricimab maintains substance integrity and sterility after compounding and storage in two different polypropylene syringe types
Authors: Taschauer Alexander , Sedivy Arthur , Egger Daniel , Angermann Reinhard , Sami Haider , Wunder Claudia , Waldstein Sebastian
Published: April 2024

Background:
Compounding and storage of intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents in syringes is commonly performed in an off-label manner. However, preservation of compound integrity and microbiological safety must be guaranteed. The aim of this study was to compare the chemical and physical stability, sterility, and binding affinity to vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) of faricimab, a novel bispecific anti-VEGF/Ang-2 biologic, after compounding and storage in two different polypropylene syringe types for up to 28 days.
Methods:
Faricimab was compounded into silicone oil-free and silicone oil-containing polypropylene syringes under controlled aseptic clean room conditions and stored under light protection at 2°C to 8°C for up to 28 days. Compound integrity was analyzed by size exclusion chromatography, nano differential scanning fluorimetry, UV-Vis and dynamic light scattering. The analysis of the simultaneous binding of VEGF and Ang-2 was performed by grating-coupled interferometry. Additionally, samples were tested for sterility and presence of bacterial endotoxins. One-way ANOVA test was used to analyze statistical significance (p ≤0.05).
Results:
No significant differences in VEGF and ANG-2 binding affinity were found in faricimab samples stored in either syringe type after 28 days compared to control. Chemical and physical stability testing revealed no statistically significant variation. Furthermore, sterility and the absence of bacterial endotoxins could be maintained.
Conclusion:
Our findings confirm the pharmaceutical safety of compounded faricimab after storage for up to 28 days. This may facilitate a cost effective off-label use of faricimab in clinical practice while maintaining safety in the treatment of patients.
Insecticidal and repellent activity of essential oils from Copaifera reticulata, Citrus paradisi, Lavandula hybrida and Salvia sclarea against immature and adult stages of Ctenocephalides felis felis
Authors: Lima Emily Andressa Santos , Campos Diefrey Ribeiro , Soares Eduardo Fellipe Melo Santos , Fortunato Anna Beatriz Ribeiro , Silva Taynara Monsores e , Pereira Nayana de Figueiredo , Chaves Douglas Siqueira de Almeida , Cid Yara Peluso , Coumendouros Katherina
Published: April 2024

Purpose

The flea Ctenocephalides felis (Siphonaptera: Pulicidae), parasitizes dogs and cats globally, acting as a vector for various pathogens affecting both animals and humans. Growing interest in environmentally friendly, plant-based products prompted this study. The aim of the study was to determine the chemical composition of essential oils (EOs) from Copaifera reticulata, Citrus paradisi, Lavandula hybrida and Salvia sclarea, assessing their insecticidal and repellent properties, determining lethal concentrations (LC50 and LC90), and evaluating residual efficacy in vitro against Ctenocephalides felis felis.

Methods

Gas Chromatography with Flame Ionization Detector analyzed EO composition. In vitro tests involved preparing EO solutions at various concentrations. Ten specimens from each life stage (egg, larva, pupa, adult) were used for insecticidal activity assessment. For immature stages, Petri dishes were used. Mortality percentage was calculated using (number of dead insects X 100) / number of incubated insects. Probit analysis calculated LC50 values with a 95% confidence interval.

Results

Major EO constituents were β-caryophyllene (EOCR), linalool (EOLH), linalyl acetate (EOSS), and limonene (EOCP). LC50 values were obtained for all stages except for the essential oil of C. paradisi. All oils showed repellent activity at 800 μg/cm2. OECR exhibited greater residual efficacy.

Conclusion

Each EO demonstrated superior insecticidal activity against specific C. felis felis stages.
Breast Milk Bacteria: The Key to Regulating Defecation Frequency Changes in Infants
Authors: Huang Yongkun , Zhang Yuanyuan , Liu Kai , Chen Yan , Xie Zhen-Rong , Li Meng , Xiong Jingjing , Li Zhanhua , Xie Yunfei , Xiong Zhaoxia , Liu Mei
Published: April 2024

Breastfeeding can significantly impact the establishment of the infant's intestinal microbiota. In this study, we hypothesized that maternal breast milk bacteria were associated with variations in defecation frequency in infants aged 1 to 6 months who were exclusively breastfed, and we sought to identify potential breast milk microbiota diagnostic markers. 102 exclusively breastfed infants aged at 1 to 6 months were enrolled in the study. Then, we collected their mothers' breast milk as samples for 16S rRNA sequencing evaluation of microbiotas. The results revealed a clear distinction between the three groups regarding microbiota structures and compositions. Changes were observed in the various species and genera, and the breast milk microbiota features Hydrogenobacteria, Serratia, and Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium were confirmed as potential biomarkers for regulating the change in neonate defecation frequency. This study demonstrates a significant correlation between the frequency of defecation in exclusively breastfed infants and the microbiota in their mothers' milk. It was discovered that the human breast milk microbiota may play a significant metabolic role in amino acids and oligosaccharides during its colonization in infants' intestines, which influences their defecation frequency. Our research provides new evidence and hypotheses regarding the association between infant defecation frequency and breast milk microbiome.
Trial Registration
This trial was registered on 22/12/2023 at www.chictr.org.cn as ChiCTR2300078973.
Blocking the TRAIL-DR5 pathway reduces cardiac ischemia-reperfusion injury by decreasing neutrophil infiltration and neutrophil extracellular traps formation
Authors: Wang Xuance , Xie Ran , Zhao Dan , Wang Guiling , Zhang Lijie , Shi Wei , Chen Yanyan , Mo Tingting , Du Yuxin , Tian Xuefei , Wang Wanjun , Cao Run , Ma Yuanfang , Wei Yinxiang , Wang Yaohui
Published: April 2024

Purpose Acute myocardial infarction (AMI) is a leading cause of mortality. Neutrophils penetrate injured heart tissue during AMI or ischemia-reperfusion (I/R) injury and produce inflammatory factors, chemokines, and extracellular traps that exacerbate heart injury. Inhibition of the TRAIL-DR5 pathway has been demonstrated to alleviate cardiac ischemia-reperfusion injury in a leukocyte-dependent manner. However, it remains unknown whether TRAIL-DR5 signaling is involved in regulating neutrophil extracellular traps (NETs) release.
Methods This study used various models to examine the effects of activating the TRAIL-DR5 pathway with soluble mouse TRAIL protein and inhibiting the TRAIL-DR5 signaling pathway using DR5 knockout mice or mDR5-Fc fusion protein on NETs formation and cardiac injury. The models used included a co-culture model involving bone marrow-derived neutrophils and primary cardiomyocytes and a model of myocardial I/R in mice.
Results NETs formation is suppressed by TRAIL-DR5 signaling pathway inhibition, which can lessen cardiac ischemia-reperfusion injury. This intervention reduces adhesion molecules and chemokines releasing, resulting in decreased neutrophil infiltration and inhibiting NETs production by downregulating PAD4 in neutrophils.
Conclusion This work clarifies how the TRAIL-DR5 signaling pathway regulates the neutrophil response during myocardial I/R damage, thereby providing a scientific basis for therapeutic intervention targeting the TRAIL-DR5 signaling pathway in myocardial infarction.