bluuebunny/crossref_metadata_2025 huggingface dataset:
Дети и тексты
Authors: Шапиро Надежда
Published: September 2021

Книга посвящена изучению словесности в школе и основана на личном педагогическом опыте автора. В ней представлены наблюдения и размышления о том, как дети читают стихи и прозу, конкретные методические разработки, рассказы о реальных уроках и о том, как можно заниматься с детьми литературой во внеурочное время. Один раздел посвящен тому, как учить школьников создавать собственные тексты. Издание адресовано прежде всего учителям русского языка и литературы и студентам педагогических вузов, но может быть интересно также родителям школьников и всем любителям словесности.
Prevalence of ‘Researcher’s defined’ and ‘Self-rated’ Successful Aging among Pre-Retirement Public Servants
Authors:   Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hairodin Khairul Rafizah , Ismail Aniza ,   Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Shamsuddin Khadijah ,   Department of Community Medicine, Medical Faculty, Universiti Kebangsaan Malaysia, Mohd Miskam Hazlina ,   Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia
Published: September 2021

Introduction The socioeconomic impact of aging population can be reduced if majority of people achieve successful aging. This study aimed to determine the prevalence of researcher’s defined successful aging (RDSA) and self-rated successful aging (SRSA) among pre-retirement public servants and their predictors. Methodology The sample included 1,064 pre-retirement public servants (50 to 60 years old) from nine government agencies. Data was analyzed using Multiple Logistic Regression to test for the association between the studied factors and SA. Results The prevalence of RDSA and SRSA was 37.5% and 98.7%, respectively. Results showed four (4) significant factors with higher odds of having RDSA were not obese, good social support, being physically active and younger age. Meanwhile, five (5) factors highly selected by respondents as predictors for SRSA were having good spiritual or religious practice, happy family, good psycho cognitive function, social support and good physical function. Conclusion The prevalence of SRSA was higher despite the presence of self-reported chronic diseases and physical limitation identified among respondents. The discrepancy in both prevalence of SA reflects the differences that exist between the criteria for SA perceived by respondents and researchers. Misperception among respondents of their aging process as ‘successful’ despite having diseases or disability may worsen their health status because they continue practicing unhealthy lifestyles without action to improve it. Promotional activities on SA, regular health screening since young and healthy working environment should be implemented by various agencies. Keywords Successful aging - pre-retirement - public servants - predictors
A preliminary information on spider fauna (Arachnida, Aranei) of the Fastiv district (Kyiv region)
Authors: Yanul V. , Singayevskiy E.
Published: September 2021

In this article, an inventory of the spider fauna of the Fastov district of the Kiev region was carried out, an annotated list of spiders was compiled and includes 84 spider species of 67 genera from 20 families. The annotated list contains faunistic material, collection method and biotopic preferences of species. The most represented by the number of species in the fauna are the families Araneidae – 19 species (24 %), Thomisidae – 8 species (9 %) and Salticidae – 8 species (9 %). The dominance of species of the family Araneidae is due to the large proportion of the surveyed habitats and vegetation layers inhabited by orb weaving spiders. In general, widespread species of spiders with high ecological plasticity were prevail. Including 10 species: Clubiona caerulescens, Harpactea rubicunda, Haplodrassus silvestris, Zelotes electus, Diplostyla concolor, Tenuiphantes flavipes, Agroeca brunnea, Pardosa amentata, Pseudeuophrys erratica and Ozyptila praticola were recorded in the litter layer of a pine forest only. Three species: Cyclosa oculata, Oxyopes ramosus and Dolomedes plantarius are rare according to the literature data. Five species were found in near-water habitats: Larinioides cornutus, Clubiona phragmitis, D. plantarius, Tetragnatha extensa, and Marpissa radiata, and were not found in the other biotopes. Two species, Metellina segmentata and Tetragnatha montana, are found on near-water vegetation and forest edges. In buildings and in household plots, two synanthropic species were found – Tegenaria domestica and Parasteatoda tepidariorum. The zoogeographic and taxonomic
compositions of the araneofauna of the region under study are presented. Arealogically, the basis is made up of the Palaearctic (35 %) and Holarctic (19 %) groups. West-Central-Palaearctic species – 14 %, European-Ancient Mediterranean – 12 %. European and more northern European-Siberian species account for 8 and 5 %, respectively. In comparison with the data for Polesie, the araneofauna of the Fastov region has certain characteristics, namely: a large participation in the composition of the araneofauna of Palaearctic and Holarctic species, a decrease in the proportion of EuropeanSiberian species and an increase in the proportion of European-Ancient Mediterranean groups of species.
Factors Affecting Selection of Excavation Support System
Authors: Adel M. El-Kelesh Dena A. Hassan,
Published: September 2021

The choice of an excavation support system (ESS) is an important decision, that has a significant impact on the project cost, schedule, and safety. In this decision, numerous critical factors must be considered, however not enough information are available in this early phase of the project. This study aims to determine the crucial factors and their relative weight during the selection process, to provide the decision-maker with a solid base to compare between ESS and overcome the lack of knowledge in this early project phase. Therefore, a literature review was carried out to identify the most critical factors, then a questionnaire was distributed to set the relative weight of these factors during the selection of an ESS. Finally, 6 case studies were used to justify and retrofit these findings.
An Investigation of Heat Transfer and Pressure Drop Enhancement of Various Perforated Circular Finned Tubes at Different Tube Tilt Angles
Authors: Yahya Yaser Shanyour AL-Salman, Ali Sabri Abbas
Published: September 2021

The thermal and flow performance of the circular annular finned tube heat exchanger with perforated fins were investigated numerically using ANSYS Fluent 2020 software, RNG k-e model with enhanced wall treatment, global performance criterion was introduced as evaluation factor of the heat exchanger performance, the parameters to be investigated were the number of holes, size of hole, tilt angle of the finned tube, fin height and spacing between fins. Agreement was found with literature that the tilt angle causes increase in heat transfer rate and increase in the pressure drop as well, but the change the global performance criterion as function to tilt angle depends on the fin heights, for higher fin heights the effective change of the pressure drop become greater than the increase in the heat transfer rate and the contrast occur in the cases of smaller fin heights, we have found that the perforation in tilted annular circular finned tubes causes an increase in the heat transfer rate and an enhancement in the total heat exchanger performance, increasing the number of holes will enhance the performance of the heat exchanger and the spacing increase reduces the heat exchanger performance.
Azot-Katkılı 3 Boyutlu Grafen Mimari Üzerinde Desteklenen Paladyum Nanopartiküllerin Doğrudan Metanol Yakıt Hücrelerinde Elektrokatalizör Olarak Kullanılabilirliğinin İncelenmesi
Authors: KARAMAN Onur
Published: September 2021

Yüksek elektroaktif özelliğe sahip elektrokatalizörlerin tasarımı, yüksek güç yoğunluğuna sahip taşınabilir yakıt hücresi sistemlerinin geliştirilmesinde kritik bir nokta olarak kabul edilmektedir. Bu çalışmada, doğrudan metanol yakıt hücresinde elektrokatalizör olarak kullanılabilecek azot-katkılı 3-boyutlu grafen (N-3DG) mimarisi ile desteklenen Pd nanoparçacıklarının sentezi için kolay ve düşük maliyetli bir üretim yöntemi önerilmiştir. Güçlü sinerjik etkilerin yanı sıra benzersiz yapısal özelliklere sahip olan Pd/N-3DG hibrit elektrokatalizörü, metanol elektrooksidasyonuna karşı, ticari Pd elektrokatalizöründen (Pd/Vulcan XC-72R) daha yüksek anodik tepe akım yoğunluk değerleri ve daha yüksek katalitik kararlılık gibi üstün elektrokatalitik performans sergilemiştir. Bu çalışma, yakıt pili teknolojisinde ticari Pd elektrokatalizörlerine alternatif olarak kullanılabilecek yüksek performanslı, düşük maliyetli elektrokatalizörlerin üretilmesi için yeni bir yaklaşımın yolunu açmaktadır.
Diskursgemeinschaften in der digitalen Transformation. Begriffsbestimmungen, Zugänge und Ziele
Authors: Dreesen Philipp , Krasselt Julia , Stücheli-Herlach Peter
Published: September 2021

This article discusses the concept of discourse community in the context of language-related discourse research in the digital transformation. In a system-theoretical interpretation of digitalization, the understanding of 'discourse community' can become more profound. This new insight allows to analytically separate analog approaches and digital approaches to discourse communities with references to basic research and applied discourse linguistics. The article points out fundamental differences in the modeling of the concept of 'discourse community' based on theoretical and methodological positions.
„Es gibt gute Menschen, die hier leben, und es gibt schlechte Menschen“. Sprachliche Verfahren der Konstitution von Diskursgemeinschaften am Beispiel des Migrationsdiskurses
Authors: Völker Hanna , Spieß Constanze
Published: September 2021

Political communication often aims at establishing a community. By participating in a discourse, the discourse actors position themselves not only on the given topic, but also with other participants in the discourse; they are often actors and/or representatives of specific communities of practice (cf. Eckert & McConnel-Ginet 1992). Based on these considerations, the contribution examines linguistic practices with an effect of creating or denying community at the example of the German migration discourse. Applying a discourse analytical approach, the analysis of a corpus of plenary debates focuses on the linguistic realisation of self- and other-positioning.
„Handeln statt Hoffen“. Zur Gemeinschaftsanrufung durch Attribution von Verantwortungsgefühlen im medialen Diskurs zur Seenotrettung von Carola Rackete im Sommer 2019
Authors: Radeiski Bettina , Steinmetz Eva
Published: September 2021

The article addresses a narrative of communanlity stemming primarily from feelings of responsibility. Referencing selected media reports on Carola Rackete’s sea rescue operation in 2019, the article discusses the circumstances under which a society calls on its individual members to act in a spirit of responsibility for their community - and at which point this common hope actually results in common action. The paper focuses on what constitutes responsible communities real and imagined, i.e. the discursive processes by which a community is invoked through the attribution of feelings of responsibility. The article employs methodological elements from linguistic and social science discourse research.
Survei Tingkat Kondisi Fisik Peserta Ekstrakurikuler Futsal Putri SMA Negeri 2 Batu
Authors: Bastian Wildan Wimba , Hariyanto Eko
Published: September 2021

Olahraga futsal bukan hanya teknik dan taktik saja yang diperlukan, melainkan juga kondisi fisik yang baik. Demikian juga pada kegiatan ekstrakurikuler futsal putri SMA Negeri 2 Batu, kondisi fisik yang buruk akan berdampak terhadap penampilan teknik dan taktik peserta. Tujuan penelitian ini adalah untuk mengetahui tingkat kondisi fisik peserta ekstrakurikuler futsal putri SMA Negeri 2 Batu. Penelitian ini termasuk penelitian deskriptif menggunakan metode survei dengan pengumpulan data menggunakan tes dan pengukuran. Hasil keseluruhan kondisi fisik peserta ekstrakurikuler futsal putri SMA Negeri 2 Batu yaitu terdapat dua unsur yang menunjukkan kategori “Rata-rata” yaitu kelincahan dan kelentukan, sedangkan unsur daya tahan, kecepatan dan daya ledak menunjukkan kategori “Di bawah rata-rata” dan “kurang”. Dari lima unsur kondisi fisik dapat disimpulkan bahwa kondisi fisik menunjukkan kategori “Cukup”.
Perilaku konsumtif sebagai dampak online shop di kalangan mahasiswa Sosiologi 2019 Universitas Negeri Malang
Authors: Rahayu Catur Dian , M Hasna Bararah , Zuhdi Kalya Nabila , Perdana Muhammad Iqbal , Aprilia Nabilah Fina , Dionchi Pramana Herjati Putra , Yuniar Ananda Dwita
Published: September 2021

The presence of technology brings about a change in people's lives, with technology of all activities being more comfortable. Technological changes have taken place in the field of digital marketing, such as shopping online. The presence of an online shop provides considerable comfort in shopping activities. But with that convenience, it can also establish higher consumption patterns. This consumption pattern was analyzed using the concept of the consumption of Jean Boudrilland. The study USES a descriptive qualitative approach with the data-collection technique of structured interviews. In the study two results have been found, the first of these is consensual behaviors among sociology students where they buy goods through online shops out of sheer need. The second result was that a sociology student was seeking to remain unaffected by the ease of shopping through online shops in order to avoid the form of consumer behavior. From such exposure it can be concluded that the concept of consumptive society by Jean Boudrilland is relevant to today's lives where people tend to satisfy the urge to buy things instead of the need.

Kehadiran teknologi membawa perubahan dalam kehidupan masyarakat, dengan adanya teknologi segala aktivitas dapat dilakukan dengan lebih nyaman. perubahan karena teknologi turut hadir dalam bidang digital marketing seperti hadirnya online shop. Kehadiran online shop cukup memberikan kenyamanan dalam aktivitas belanja. Namun dengan kenyamanan tersebut dapat pula membentuk pola konsumsi yang semakin tinggi. Pola konsumsi ini dianalisis menggunakan konsep masyarakat konsumsi dari Jean Boudrilland. Penelitian ini menggunakan metode pendekatan kualitatif deskriptif dengan teknik pengumpulan data yakni wawancara terstruktur. Dalam penelitian ini ditemukan dua hasil, yang pertama adanya perilaku konsumtif di kalangan mahasiswa sosiologi dimana mereka membeli barang melalui online shop karena keinginan bukan kebutuhan. Hasil yang kedua yakni ditemukan adanya mahasiswa Sosiologi yang berusaha untuk tidak terpengaruh kemudahan berbelanja melalui online shop dengan tujuan agar tidak terbentuk perilaku konsumtif. Dari pemaparan tersebut dapat disimpulkan bahwa konsep masyarakat konsumtif oleh Jean Baudrillard relevan dengan kehidupan saat ini dimana masyarakat cenderung memuaskan keinginan membeli suatu barang bukan atas dasar kebutuhan.
Peran identitas sosial budaya siswa kursus Kampung Inggris dalam pola interaksi dan pergaulan
Authors: Engracia Nesya Vashti , Perguna Luhung Achmad
Published: September 2021

Setiap individu dalam hidupnya pasti memiliki identitas sosial dan budaya. Sebagai contoh dalam memulai perkenalan, individu tidak akan lupa siapa dirinya. Hal ini menunjukan bahwa konsep diri individu dapat dilihat dari identitas sosial budaya nya. Artikel ini menunjukan sejauh mana peran identitas sosial budaya dalam melakukan interaksi dan menentukan pergaulan pada siswa kursus Kampung Inggris Pare. Dengan menggunakan metode studi pustaka, yaitu melalui penelitian terdahulu dan teori identitas sosial sebagai pelengkap, penulisan artikel ini menemukan 2 hasil. Pertama, identitas sosial budaya kurang berperan dalam melakukan interaksi sehari-hari antar siswa kursus Kampung Inggris Pare Kediri. Kedua, identitas sosial budaya berperan dalam menentukan pergaulan antar siswa kursus Kampung Inggris Pare Kediri.
Tingkat literasi keuangan dan kesejahteraan hidup pengusaha batu bata Desa Urek-Urek Kabupaten Malang
Authors: Fatma Supriyanti Dian , Dandy Hadi Saputra Mochamad
Published: September 2021

Artikel ini bertujuan untuk menganalisis tingkat literasi keuangan pada pengusaha batu bata di Desa Urek-urek Kecamatan Gondanglegi Kabupaten Malang. Metode yang digunakan dalam penelitian ini yaitu metode penelitian kualitatif dengan jenis penelitian fenomenologi. Penelitian ini menggunakan data primer dan data sekunder. Data primer bersumber dari informan utama yang diperoleh melalui wawancara secara langsung dan dari pengusaha batu bata, sedangkan data sekunder diperoleh dari staf kantor Desa Urek-urek serta masyarakat disekitar wilayah usaha batu bata. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu wawancara dan observasi. Berdasarkan tingkatan literasi keuangan pengusaha batu bata yang berada di Desa Urek-urek Kecamatan Gondanglegi Kabupaten Malang, rata-rata pengusaha batu bata yang ada, sebagian besar tergolong ke dalam tingkatan literasi sedang atau sufficient literate. Literasi keuangan yang dimiliki oleh pengusaha batu bata dapat dikatakan cukup baik, hal ini ditunjukkan dengan pengusaha memilih produk yang berkualitas agar tidak mengalami kerugian baik waktu maupun biaya, memiliki investasi untuk kebutuhan jangka panjang serta dapat menambah pendapatan di kemudian hari. Tingkat literasi keuangan pengusaha batu batu berpengaruh terhadap kesejahteraan hidup dan keberlangsungan usaha yang dijalankan oleh pengusaha batu bata dalam jangka panjang.
Pengaruh Subtitusi Kelapa Parut (Cocos Nucifera) dalam Pembuatan Kue Sagon Kabocha (Cucurbita Maxima. L) sebagai Inovasi Kuliner Magetan
Authors: Ahyana Laily Maulida , Wibowotomo Budi , Hidayati Laili
Published: September 2021

Kue sagon makanan tradisional tersebar Indonesia terdiri tepung ketan putih, kelapa parut, gula, telur dipanggang, disajikan agenda besar. Inovasi subtitusi kabocha dengan kelapa parut mengetahui gizi, rasa, tekstur dan warna kue sagon. Subtitusi terdiri 3 formula yaitu kue sagon subtitusi kabocha 60 persen: kelapa parut 40 persen, kabocha 70 persen : kelapa parut 30 persen dan kabocha 80 persen : kelapa parut 20 persen. Hasil uji proksimat (protein, karbohidrat, air, lemak, abu dan serat pangan) nilai tertinggi sampel kue sagon subtitusi kabocha 60 persen : kelapa parut 40 persen protein (14,541 gr/100 gr,), lemak (17,71gr/100 gr) dan abu (5,737 gr/100 gr). Nilai bagian tertinggi uji proksimat pada sampel kue sagon subtitusi kabocha 80 persen: kelapa parut 20 persen karbohidrat (58,272 persen), air (11,5645 gr/100 gr) serat pangan (45,4635 gr /100 gr), kandungan beta karoten tertinggi 1188,142 gr /100 gr.
Problem Based Learning pada Materi Pembuatan Pola Busana Pesta Wanita
Authors: Izati Kurnia , Purwaningsih Nur Endah , Prahastuti Endang
Published: September 2021

Tujuan penelitian ini untuk mengetahui bagaimana penerapan model pembelajaran Problem Based Learning pada materi pembuatan pola busana pesta wanita. Penelitian ini menggunakan metode eksperimental pretest-postest group design. Populasi penelitian ini berjumlah 62 siswa pada kelas XII TB yang terdiri dari 2 kelas. Sampel penelitian adalah kelas XII TB 1 untuk kelas eksperimen dan XII TB 2 untuk kelas control. Menggunakan tes praktik membuat pola busana pesta wanita. Hasil uji validitas menunjukkan sebesar 0.556 dan 0.969, hasil uji reliabilitasnya sebesar 0.867 dan 0.579. Hasil uji seluruh data bersifat valid dan reliable. Hasil dari pretest pada kelas eksperimen mendapatkan nilai 75.28, untuk meningkatkan pemahaman siswa terkait dengan cara membuat pola. Dikarenakan kebanyakan siswa tidak faham dengan cara membuat pola ketika model busana yang dibuat agak sulit. Setelah peneliti melakukan treatment, peneliti melakukan posttest. Hasil posttest kelas eksperimen meningkat sebesar 85.68, sedangkan tanggapan siswa diperoleh angka 84.02 persen. model yang digunakan membuat peserta didik lebih paham tentang konsep pembelajaran. sedangkan pada kelas control didapatkan nilai rata-rata posttest sebesar 80.9. dikarenakan peserta didik hanya secara pasif menerima pengetahuan dari guru dan merasa sulit untuk mengembangkan konsep dan pemahaman. Kesimpulan dalam penelitian ini yaitu, model pembelajaran Problem Based Learning sangat baik penerapannya, serta dapat meningkatkan hasil belajar siswa.
Identifikasi Hidangan pada Upacara Kesempatan Khusus Suku Tengger di Desa Argosari Kecamatan Senduro Kabupaten Lumajang
Authors: Maryani Tria , Soekopitojo Soenar , Kiranawati Titi
Published: September 2021

Tengger tribe has a dish that is served on special occasions ceremony. The special occasion ceremony held by the Tengger tribe is inseparable from the culture and Hindus’s religion which is the majority religion of the Tengger tribe. Argosari Village is one of the villages that still carries out all special occasion’s ceremonies related to custom and religion. This village is in Lumajang Regency. This research was using qualitative descriptive research, with data collection techniques used are interviews, observation, and documentation. The data source was obtained from interviews with five informants are the Dukun Pandhita of Argosari village, Mangku village, and society’s Argosari. Data analysis is performed interactively with steps such as reduction, data presentation and drawing conclusions or verification and to check the validity of finding with member checking methode to Dukun Pandhita. The results of the research which is identifiying the special occasion dishes of Tengger tribe, there are 6 groupings dishes based on staple foods such as rice, side dishes such as omelette, fried chicken, fried noodles. Vegetable dishes include jangan benguk, jangan kentang. Snacks consist of pepes, pasung, jenang abang, apem, juadah, tetelan. The beverages such as tea and coffee. Dandananan such as gedhang ayu, pencok bakal.

Masyarakat suku Tengger mempunyai hidangan yang disajikan pada upacara kesempatan khusus. Upacara kesempatan khusus yang dilaksanakan oleh masyarakat suku Tengger tidak terlepas dari kebudayaan dan agama Hindu yang merupakan agama mayoritas suku Tengger. Desa Argosari merupakan salah satu desa yang masih melaksanakan semua upacara kesempatan khusus yang berkaitan dengan adat maupun keagamaan, Desa ini terletak di Kabupaten Lumajang. Penelitian ini merupakan penelitian deskriptif kualitatif, dengan teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Sumber data diperoleh dari wawancara dengan lima informan yaitu Dukun Pandhita teraktif dengan langkah reduksi, penyajian data dan penarikan kesimpulan atau verifikasi. Pengecekan temuan dilaksanakan dengan member checking kepada Dukun Pandhita. Hasil dari penelitian ini adalah terdapat 6 pengelompokan hidangan yang disajikan pada kesempatan khusus, yaitu makanan pokok antara lain nasi, hidangan lauk pauk berupa telur dadar, ayam goreng. Hidangan sayuran antara lain jangan benguk, jangan kentang. Sedap-sedapan yang terbagi menjadi jajanan telesan berupa pepes, pasung, jenang abang, apem, juadah, tetelan dan jajanan garingan seperti matari
Parallel Computing for Rolling Mill Process with a Numerical Treatment of the LQR Problem
Authors: Gómez Múnera John Anderson , Giraldo Quintero Alejandro
Published: September 2021

The considerable increase in computation of the optimal control problems has in many cases overflowed the computing capacity available to handle complex systems in real time. For this reason, alternatives such as parallel computing are studied in this article, where the problem is worked out by distributing the tasks among several processors in order to accelerate the computation and to analyze and investigate the reduction of the total time of calculation the incremental gradually the processors used in it. We explore the use of these methods with a case study represented in a rolling mill process, and in turn making use of the strategy of updating the Phase Finals values for the construction of the final penalty matrix for the solution of the differential Riccati Equation. In addition, the order of the problem studied is increasing gradually for compare the improvements achieved in the models with major dimension. Parallel computing alternatives are also studied through multiple processing elements within a single machine or in a cluster via OpenMP, which is an application programming interface (API) that allows the creation of shared memory programs.
Simulación de modulación por ancho de pulso usando Tinkercard
Authors: Perdomo Victor Hugo
Published: September 2021

Este trabajo tiene como finalidad usar la plataforma Tinkercard para comprender los conceptos de la señal PWM (modulación por ancho de pulso). Dicha plataforma nos permite crear una simulación don se pueda observar fácilmente términos como el DutyCycle (ciclo de trabajo), el periodo de la señal, la frecuencia de la señal, el tiempo de encendido de la señal, el tiempo de apagado de la señal, entro otras terminologías que se deben tener en cuenta al hacer uso de esta modulación por ancho de pulso. La ventaja más importante del uso de tinkercard es su facilidad de uso y su accesibilidad ya que es gratuita y muy intuitiva, así cualquier persona puede usarla sin previo conocimiento sobre ella.
MUTATIONAL CONSERVATION, EVOLUTIONARY AND FUNCTIONAL UNDERSTANDING OF PROTO-ONCOGENE c-FOS
Authors:   Amity Institute of Biotechnology, Amity University, Uttar Pradesh Lucknow 226028, UP, INDIA, Yadav Ruchi
Published: September 2021

c-Fos protein has a function in different types of cancers and is expressed mostly in neurons. It is a human homolog of the viral oncogene. c-Fos is a member of the FOS gene family, these genes interact with the JUN family member to form transcription factors and play a major role in neurons cell development. These genes were also used as an early marker, in neuronal cells to determine early growth and functional features of the neuroendocrine system. Losses in gene function due to mutation leads to neuronal death and have a function in apoptosis. This study has performed mutational conservation in the c-Fos gene across different species. the c-Fos protein sequence was retrieved from the UniProt database (P01100). Total forty nine (49) homologous sequences with the c-Fos protein sequence were identified using the BLASTp tool. Multiple sequence alignment (MSA) and phylogenetic tree construction was done using the MEGA tool. The phylogenetic tree shows that the c-Fos protein of Homosapiens was closely related to Pan troglodytes. UPGMA tree also shows the evolutionary relationship between c-Fos proteins and with the other 49 species included in the dataset. Evolutionary study shows that Myotis species was the common evolutionary species and predicted as root for all other species hence c-Fos gene might have an evolutionary link with these species. Myotis are the most wide diverged species and belongs to the genus of bats. This study highlights the similarity and evolutionary relationship of the c-Fos gene. In this research detailed analysis of evolutionary analysis, PPI, GO, Disease Enrichment was done to understand the functional and evolutionary aspects of c-FOS protein. This study identifies the evolutionary relationship, protein-protein interaction and pathway enrichment of the c-FOS protein. This research can be further extended to include ligand screening and identification of potential ligand against c-FOS protein for drug development and discovery.
FBDD: In-silico STRATEGY TO INHIBIT MPRO ACTIVITY USING DRUGS FROM PREVIOUS OUTBREAKS
Authors:   Post Graduate Department of Biosciences, Centre of Advanced Study in Bioresource Technology Sardar Patel University, Satellite campus, Bakrol-Vadtal road,    Bakrol - 388315, Anand, Gujarat, India, Trivedi Gauravi N , Karlekar Janhavi T ,   Indukaka Ipcowala Centre for Interdisciplinary Studies in Science and Technology  Sardar Patel University, Nr. Bus Stop, B/h Shastri Maidan, Vallabh    Vidyanagar – 388120, Gujarat, India, Dhimmar Khushbu ,   Post Graduate Department of Biosciences, Centre of Advanced Study in Bioresource Technology Sardar Patel University, Satellite campus, Bakrol-Vadtal road,    Bakrol - 388315, Anand, Gujarat, India, Panchal Hetal kumar ,   Post Graduate Department of Biosciences, Centre of Advanced Study in Bioresource Technology Sardar Patel University, Satellite campus, Bakrol-Vadtal road,    Bakrol - 388315, Anand, Gujarat, India
Published: September 2021

Main protease (Mpro) and Spike (S) proteins are said potential drug targets of COVID-19. Pneumonia like respiratory illness caused by SARS-CoV-2 is spreading rapidly due to its replication and transmission rate. Protease is the protein that is involved in both replication and transcription. Since CoV-2 shares, genomic similarity with CoV and MERS-CoV, drugs from previous outbreaks are used as primary treatment of the disease. In-silico drug development strategies are said to be faster and effective than in-vitro with a lesser amount of risk factors. Fragment Based Drug Designing (FBDD), also known as rational drug design in which a potential target protein is selected and docked with a lead-like molecule that eventually leads to drug development. Nine (9) drugs that are currently being used to treat patients of coronavirus were selected in this study from the latest literature review and fragmented as per rules followed by crosslinking of drug fragments using editor tools. These native drugs and synthesized drugs were then docked against the main protease. Results of the study revealed that one of the crosslinked lead-like compounds showed a higher binding affinity (∆G) more than any of the native compounds. Further, the results of this study suggested that the combination of potential drugs can be an effective way to develop new drugs to treat a deadly disease.
Measurement of K Level Natural Line Widths, Kα1 and Kα2 X-Ray Line Widths
Authors: SÖĞÜT Ömer
Published: September 2021

Bu çalışmada Ti, V, Cr, Mn, Fe, Co, Ni, Cu ve Zn element ve bileşiklerinin K kabuğu doğal çizgi genişlikleri ile Kα1 ve Kα2 X-ışını çizgi genişlikleri yarı deneysel olarak, K kabuk flüoresans verimi değerleri kullanılarak hesaplandı. Numuneleri uyarmak için 75mCi şiddetinde ve 59. 5 keV enerjili gama ışınları yayınlayan 241Am radyoizotop kaynağı kullanıldı. Numunelerden yayınlanan K X-ışınlarını saymak için çözünürlüğü 5.96 keV'de 155 eV olan katı hal Si(Li) detektörü kullanıldı. Kimyasal yapıya bağlı olarak K seviyesi doğal çizgi genişliği ile Kα1 ve Kα2 X-ışını çizgi genişliklerinin değiştiği tespit edildi. Sonuçlar bileşiklerde ölçülen ΓK, ΓKα1 and ΓKα2 çizgi genişliklerinin saf element değerlerine göre % 5-48 kadar değiştiğini göstermektedir. Ancak, saf elementler için ölçülen deneysel sonuçlar, literatürdeki diğer araştırmacıların sonuçlarıyla hata sınırları dâhilinde iyi bir uyum içinde olduğu bulunmuştur.
Anticancer Profiling of Gambogic Acid as a Target Specific RANKL Inhibitor in Osteosarcoma Cell Line
Authors: ÖZGÜR Aykut , DUMAN Esra
Published: September 2021

Osteosarcoma is a common cancer type among the youth population and usually develops in growing bones. Approximately twenty percent of osteosarcoma cases show tendency to metastases and patients with osteosarcoma have a low survival rate after treatment. RANK/RANKL/OPG key regulator triad of bone remodeling play critical roles in tumourigenesis of osteosarcoma. Anti-proliferative activity of the gambogic acid was determined in Saos-2 cell line by XTT assay. To understand the anticancer activities of the gambogic acid, molecular docking calculations were also performed with RANK-RANKL complex. The expression levels of the RANKL and OPG was measured at gene and protein level with RT-PCR and ELISA assays. Its potential anti-invasive property in-vitro against osteosarcoma cells was evaluated using wound healing assay. Experimental assays indicated that gambogic acid suppressed cell proliferation, cell migration, and decreased protein expression ratio of RANKL/OPG in Saos-2 cells. Gambogic acid binds to RANK-RANKL complex with Kd value of 549.38 nM and with estimated free energy of binding -8.54 kcal/mol. Gambogic acid is found to be significant drug template for target specific osteosarcoma treatment.
Expansion of the Inhomogeneous Modular Transformations with Modular Group Properties
Authors: YILDIZ İsmet , ALTUN Kezban , ÖZTÜRK Betül , ŞAHİN Hasan
Published: September 2021

In this study, inhomogeneous modular groups and their basic properties are examined, and the relationships between homogeneous and inhomogeneous linear transformation concepts are discussed. The definition of the modular group is demonstrated by using inhomogeneous linear transformations. With the help of modular group conditions, the upper half-plane is defined with the help of the images under the elements of the modular group gama and the formation of inhomogeneous modular transformations on different transformations is examined. In addition, the theorem about the cases of the modular group has been determined with a distinct method
X-ray Properties of Spitzer/IRAC Selected AGNs
Authors: İKİZ Tuba
Published: September 2021

Spitzer/IRAC color selection is a powerful tool to identify hot accreting nuclei, that is to say AGN, in galaxies. In this study, mid-infrared detected candidate 36 AGNs are used that are selected from the Spitzer Survey of Stellar Structures in Galaxies (S4G) sample consisting of more than 2500 galaxies together with its extension sample of more than 400 galaxies by İkiz et al., (2020). Mid-infrared color selection method is tested by examining the X-ray properties of the galaxies via the XMM-Newton and Chandra. Using the X-ray data, we demonstrate that galaxies displaying hot mid-infrared nuclei stand out as (candidate) active galaxies. 64% of mid-infrared-selected AGN are detected at X-ray energies in XMM-Newton and Chandra data. It has been hypothesized that IRAC sources with AGN colors that lack X-ray detections are predominantly high-luminosity AGN that are obscure.
El origen del capitalismo de amigos latinoamericano actual: la operación de redes de intereses e instituciones clave en el periodo colonial
Authors: Galindo Rodríguez José
Published: September 2021

Este artículo reflexiona sobre el origen de la corrupción colusiva, término contemporáneo que en su definición vincula a empresarios y políticos por medio de la formación de redes y que bajo ciertos escenarios es sinónimo de capitalismo de amigos. Se estudian características y particularidades de las redes de intereses principalmente desde fines del periodo colonial, así como su peso en limitar intentos por reformar instituciones específicas de la Nueva España y otros virreinatos de la Corona española. La tesis principal del artículo es que ciertas prácticas coloniales que llevaron a la formación de redes entre comerciantes y gobernantes y que ocurrieron bajo cierto contexto sentaron un precedente para el capitalismo de amigos de la actualidad. Para ello, en el artículo se contrastan hallazgos y afirmaciones de diversas y destacadas fuentes secundarias, debidamente contextualizadas. El artículo concluye con elementos que permiten repensar el tema de la continuidad de las prácticas de colusión hasta el presente.
Noticias del BID: Vol. 6, no. 6, agosto 1979
Authors:   Inter-American Development Bank
Published: September 2021

Noticias del BID, publicación mensual que tiene por objetivo informar acerca de las actividades del Banco Interamericano de Desarrollo.
Finland in Search of Foreign Policy Guidelines
Authors: Rupasov Aleksander
Published: September 2021

The article analyzes Finland's attempts to find a solution to current foreign policy problems in the interwar period. The main problem was the search for possible allies and guarantors of independence. The solution to this problem was complicated by a complex of factors: the limited interest of the great powers in accepting obligations guaranteeing the preservation of independence by Finland, the political and military weakness of possible allies (Latvia and Estonia), contradictions in relations with Sweden (not least caused by domestic political aspects both in Finland and Sweden), fears about Poland's foreign policy ambitions, potentially dangerous Finnish involvement in crisis situations Domestic political consensus on the issue of foreign policy orientation seemed to be achieved in the mid-1930s. However, the so-called Scandinavian orientation did not even partially solve the security problem. By the beginning of the pan-European crisis, the search for guarantors of independence remained an unresolved problem.
Authorized Representatives of the Council of Lithuania in Moscow in 1918
Authors: Grigaravičiūtė Sandra
Published: September 2021

Based on the documents from Lithuanian and German archives, the material kept in the Manuscripts Department of the Wroblewski Library of the Lithuanian Academy of Sciences, the information published in the press and collections of documents, the article analyzes the context and motives of the appointment of Česlovas L(i)andsbergis to the position of the authorized representative of the Council of Lithuania in Moscow (Russia), the content of the powers vested in him, the conflict with the German Consul General in Moscow, and the motives of his removal from office. It also addresses the circumstances of delegating Tadas Šulcas to serve as the general country representative of the State Council of Lithuania in Moscow, the specificities of the activities of the Moscow Representation of the Authorized Representative of the Council of Lithuania, and return to Lithuania. Particular attention is paid to Germany’s position concerning Lithuania’s diplomatic representation (April — May and July — October), the efforts of German consuls general in Moscow and Petrograd to turn the authorized representatives of the Council of Lithuania into the chairmen of the commissions subordinate to them and the continuous opposition of the Presidium of the Council of Lithuania to the plans of the German government.
Reasons for the professional deformation of intelligence officers
Authors: Makhmudova Irina N.
Published: September 2021

The article reveals the psychological mechanism of professional and psychological behavior ofintelligence officers in conditions of risk. Professional deformation is associated mainly with the specifics of theprofession, the situation in which special services specialists have to work. The motives of the readiness to act in theregime of extreme danger and increased danger are revealed. The factors influencing the specifics of the behavior of different employees to act differently in the same situations are described. The theoretical understanding of personality and internal locus-control is given. In this regard, these motives and non-motives of risk are revealed, as well as risk for the sake of. The reasons why there is a probability of personnel risks in the organization are revealed. A comparative characteristic of the concepts of "stress resistance" and "self-control" is given. The influence of the propensity of aspecial services specialist to take risks on his psychological readiness to take action in the extreme mode is shown. The relationship between risk readiness and motivation to avoid failures is described. An explanation is given why older employees are less prepared for risky actions in non-standard situations.
Financing of innovative projects in industry
Authors: Galachieva Svetlana V.
Published: September 2021

A distinctive feature of innovation-oriented enterprises is a higher demand for external sources of financing, while innovative activities are characterized by a sufficiently high degree of uncertainty and risk, therefore, the important principles of financing innovative projects are the multiplicity of financing sources, flexibility and adaptability to a rapidly changing external environment. Using in-house funds in the development and implementation of an innovative project provides maximum scale of actions in making management decisions. At the same time, international experience in the innovative projects implementation proves the effectiveness of debt and equity instruments use for project financing. The article discusses the main instruments for financing innovative projects in the Russian Federation, highlights the main stages of finding and attracting financial resources. In addition, within the framework of this study, the costs of technological innovations and the sources of their financing, the patent activity of enterprises in the Russian Federation were analyzed. The main economic reasons that impede the development of innovations project management are listed. The necessity of developing measures to expand the access of innovative enterprises to loaned sources of financing has been substantiated.
Managing the digital transformation of the industrial sector
Authors: Zhityaeva Oksana I.
Published: September 2021

The article examines the issues of managing the digital transformation of the Russian industrial sector. The author notes that a new content of the industrial development strategy is currently on the agenda a digital strategy, for the development of which there are a number of prerequisites: the availability of the Internet, the use of digital services, mobile devices, and other digital technologies. The article deals with the issues of digital transformation management and the directions of its development. The author reveals the advantages of implementing digital transformation, suggests directions for implementing the roadmap for digital transformation of the industrial sector, and identifies trends in the digital transformation of the industrial sector. It is noted that digital transformation begins with the creation of a digital platform where the interests of industry, the state and science are united. Digital platforms are proposed to be organized by type of economic activity (FEA), using digital ecosystems. Digital platforms are proposed to be created in the areas of digital transformation, such as: uber-ization, the Internet of things, neural technologies, Big Data, network interaction with partners, blockchain, crowdfunding. The article reflects that one of the types of digitalization is uber-the transformation of the economy, which represents a digital service for the provision of services, the rejection of hierarchical multi-level organizational structures, to production and management structures based on the blockchain. Uber-ization of the economy is a digital management service that includes a whole range of other digital services. In this article, the author proposes a model of digital transformation of the industrial sector of the Russian Federation based on the creation of digital doubles that allow using such advantages as reducing the time of business processes, increasing the accuracy of calculations, and improving the quality of work performed. Digital transformation forms new forms of organizational, innovation and management activities, takes a leading position in the development of domestic industrial potential, new competitive advantages by improving business processes for knowledge and information management, increasing the number of technological innovations, and filling them with professional competencies.
Analysis of financing and role of world-class research and education centers in the Russian Federation
Authors: Anisimova Valeriya Yu. , Gaffarli Elvin P.
Published: September 2021

The article analyzes the role of science in the development of state, world-class scientific and educational centers and their role in the innovative development of regions. The article presents the indicators of financing of REC. The sources and mechanisms of REC financing are analyzed. The effectiveness of functioning and impact of REC on the economy of the region is revealed. Possible reasons are given for the fact that the share of federal budget funds, specifically grants, is no more than 14,5 %, depending on the REC. It is noted that the main expenditures of the regional budget are directed to fundamental and applied research that meets the criteria and requirements of the regional market, the purchase of educational and scientific equipment, and the support and development of production enterprises that are members of REC. The creation of the REC will raise the prestige of science in the state, and the real sector of the economy is included in this process. The activities of scientific and educational center will also affect the structure of the GRP of the region. It was found that the functioning of RECs has positive socio-economic effects. This is reflected in the REC's performance targets, which are reflected in their work programs. In general, the functioning of the REC will have positive socio-economic effects, such as increasing the standard of living and attractiveness of the region; improving the environmental situation; increasing the production of innovative and high-tech products; increasing the level of GRP; creating new jobs; improving and developing the scientific and educational environment of the region.
Features of the formation of an institutional approach to the development of domestic industrial production
Authors: Podbornova Ekaterina S. , Melnikov Maxim A.
Published: September 2021

The article examines the current state and potential development of the domestic industry on the basis of an assessment of the existing discussion in the economic community for the validity and feasibility of the current import substitution policy in the context of the intensifying foreign policy confrontation. An overview of a number of proposed directions for improving the industrial complex of the Russian Federation using innovations in the management of development and improvement processes based on research on existing and potential achievements can help in determining a rational vector for the development of domestic production forces with further strengthening of the national economy with a simultaneous increase in the welfare of the country's population. An analysis of the measures proposed by a number of authors for the development of domestic industry is carried out, an assessment is made of the proposed plans and roadmaps based on the organization of interaction between public and private structures, to increase the effectiveness of measures taken in the creation of a modern industry on an innovative basis in both production and organizational spheres. The experience available to date in the implementation of roadmaps and international cooperation programs makes it possible to assess the previous theories. And the existing achievements in this area make it possible to further improve the processes of modernization of the management of the domestic industrial complex. The use of the institutional approach in relation to measures to improve the domestic industrial complex makes it possible to more clearly form the mechanisms for the development, implementation and control of measures, taking into account the specifics of the factors affecting the final version.