bluuebunny/crossref_metadata_2025 huggingface dataset:
РОЛЬ ВОЛОНТЕРСЬКОГО РУХУ У ЗМІЦНЕННІ ЗБРОЙНИХ СИЛ УКРАЇНИ ТА ОБОРОНОЗДАТНОСТІ ДЕРЖАВИ
Authors: Стасюк Юрій , Томчук Олександр
Published: May 2022

У статті аналізується історія виникнення та значення волонтерського руху у відновленні ЗС України та зміцненні обороноздатності держави. Автори зазначають, що надання волонтерської допомоги ЗС України у скрутні часи для держави є унікальним явищем, притаманним українському народові. Подано історію зародження сучасного волонтерського руху та основні напрями діяльності волонтерів у ЗС України. Наголошується на всенародному характері волонтерства, його значенні у відсічі російській агресії проти України. Автори аналізують нормативну базу руху допомоги ЗС України, наводять приклади допомоги українським збройним формуванням.

Ключові слова: Збройні Сили України, волонтери, волонтерський рух,

благодійність, волонтерські та благодійні організації.
РОЗВИТОК НОРМАТИВНО-ПРАВОВОЇ БАЗИ З ПИТАНЬ ЗАДОВОЛЕННЯ РЕЛІГІЙНИХ ПОТРЕБ ВІЙСЬКОВОСЛУЖБОВЦІВ ЗБРОЙНИХ СИЛ УКРАЇНИ У 1991–2017 РОКАХ
Authors: Ворощук Олексій , Новікова Валентина
Published: May 2022

У статті висвітлено деякі історичні аспекти трансформаційних процесів у розвитку нормативно-правової бази з питань задоволення релігійних потреб військовослужбовців Збройних Сил України у період 1991–2017 років, а також їх роль у процесі становлення інституту військового духовенства (капеланської служби) Збройних Сил України.

Зокрема висвітлено сукупність нормативно-правових актів з питань задоволення релігійних потреб військовослужбовців, що регламентували діяльність представників релігійних організацій, а також визначали організацію та спрямованість діяльності структур Збройних Сил України, які відповідали за напрям душпастирської опіки військовослужбовців.

Ключові слова. Українська церква, військово-релігійні відносини, військове духовенство (капеланство), духовне виховання, душпастирська опіка,  морально-психологічне  забезпечення,  задоволення  релігійних  потреб.
A Ascensão do Elefante: A Política Externa da Índia
Authors:   * Instituto do Oriente, Instituto Superior de Ciências Sociais e Políticas, Portugal, Matias Santos Pedro ,   Email: psantos@iscsp.ulisboa.pt
Published: May 2022

In the context of the East, the new world powers will be China, in first place, and India in third place, moving the USA to second world power. It is intended, in the first place, to account for China’s foreign policy and only then for India’s foreignpolicy, which is a counter-response to the former, which has its foreign policy more systematized, namely, in terms of access to oil, since this resource is scarce for both Asian world powers. Secondly, it is anticipated the study of the relationship between the internal and external policies of the Dragon and the Elephant, particularly in the latter case. It is intended to give an account of the Indian Union’s strategies of reaching out to allies as a way of reacting to the hegemonic China as well. Keywords: Domestic Policy; Foreign Policy; India; China
Demography and Characteristics of Lung Cancer Patients Evaluated by 18F-FDG PET- CT imaging - Retrospective Analysis in NINMAS
Authors: Siddique Abu Bakker , Begum Shamim MF , Mandal Tapati , Mutsuddy Pupree , Kar Rashmi , Jabin Zeenat
Published: May 2022

Introduction: Carcinoma of the lung is one of the most common cancer in Bangladesh. Fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) plays an important role in staging and evaluating therapy response. Currently, limited data is available about the demography and characteristics of lung cancer patients in Bangladesh by 18F-FDG PET-CT scan.
Objectives: To evaluate the demographic pattern and pattern of findings in lung cancer patients by 18F-FDG PET-CT scan in the National Institute of Nuclear Medicine and Allied Sciences (NINMAS), Dhaka.
Materials and Methods: This retrospective study was conducted in the PET-CT division of NINMAS. A total of 53 patients out of 103 patients with lung cancer were enrolled who were referred to NINMAS from October 2020 to December 2021 for either baseline PET CT or for assessment of therapy response. Data were collected in a predesigned format from old documents and analyzed for demographic characteristics, histopathologic, morphologic and metabolic patterns as well as a comparison of the overall number of lung cancer patients with previous years.
Results: Among the enrolled 53 lung cancer patients the majority (34%) are in the 6th to 7th decades with 56.6% male and 43.4 % female. Adenocarcinoma (62%) and squamous cell carcinoma (24%) were the most common lung cancer subtypes. The majority of patients (53%) came for a therapeutic response evaluation; among them, 32% had a good response following therapy, 25% with progressive disease and others had mixed response, partial response, and stable disease. Nine percent of the patients came for follow up and among them, recurrence is detected in 20%. Lung cancer patients who came for baseline study, (38%) were upstaged (80%) mainly with 20% remaining in the same stage.
Conclusion: The demographic pattern of lung cancer patients observed in this study belonged to 6th & 7th decades having male predominance. Most of the patients were diagnosed with advanced stages of lung cancer. The use of 18FDG PET-CT is crucial for the staging and diagnosis of suspected lung cancer, as well as therapeutic response and follow-up.
Bangladesh J. Nuclear Med. 25(1): 22-27, 2022
Primary Idiopathic Congenital Lymphedema Presenting as Swelling of Dorsum of Both Feet – A Case Report
Authors: Hasan Tanjida , Nasreen Faria , Rahman Mahbub ur
Published: May 2022

Lymphedema is a debilitating, progressive disease causing major healthcare problem. This condition is broadly classified as primary and secondary lymphedema. Congenital subtype is a rare form of primary lymphedema. Proper history taking and appropriate investigations can rule out the other differentials of lymphedema. Early diagnosis is essential for early treatment which may halt the progression and alleviate symptoms. Lymphoscintigraphy is an important but simple imaging modality which helps to diagnose and grade lymphedema initially as well as in follow up. An interesting case of primary idiopathic congenital lymphedema presenting with dorsum of feet swellings is reported here highlighting the importance of lymphoscintigraphy.
Bangladesh J. Nuclear Med. 25(1): 41-44, 2022
Estudio de Confiabilidad en Diodos Basados en AlGaN/GaN Durante el Estado de Encendido
Authors: Acurio Eliana , Trojman Lionel , De Jaeger Brice , Bakeroot Benoit
Published: May 2022

Este trabajo tiene como objetivo estudiar la degradación de los diodos de barrera Schottky (SBD) con una terminación de borde cerrado (GET) bajo condiciones de estrés en estado de encendido en tecnologías de 200V y 650V. Después de todos los experimentos de estrés, se observa un comportamiento recuperable, que indica el atrapamiento de cargas en defectos preexistentes y no creación de nuevas trampas. Un análisis estadístico amplio demuestra una mayor confiabilidad y una vida útil más larga en comparación con trabajos anteriores en una tecnología de 200 V. Para la tecnología de 650V, se analizaron variaciones en el ánodo como una doble capa GET y el uso de Al2O3/SiO2 como dieléctrico. Se obtuvo una menor degradación total en el segundo caso gracias a la compensación entre los mecanismos de resistencia de encendido (RON) y voltaje de encendido (VTON). Se observan algunas diferencias sistemáticas en la degradación de los parámetros según la ubicación de la oblea, probablemente causadas por variaciones relacionadas con el proceso. Mediante el uso de la técnica de pares coincidentes (MP), se ha demostrado que se pueden obtener distribuciones de probabilidad caracterizadas por pendientes de Weibull únicas sobre la oblea que podrían permitir una mejor caracterización de la confiabilidad intrínseca de estos dispositivos.
Faktor yang Memengaruhi Episode Transfusi Packed Red Cell (PRC) pada Anak dengan Keganasan
Authors: PURWANTO DIAN A.P , MULATSIH SRI , TRIYONO TEGUH
Published: May 2022

ABSTRACTPRC transfusion is an adjuvant therapy frequently used in children with malignancy. There are some factors affecting transfusion episodes. For rational use of PRC must consider these factors. Objective: To find factors affecting transfusion episodes in children with malignancy. This retrospective cohort study evaluated children with malignancy between January 1 and December 31, 2015 who were admitted to Sardjito hospital. Patients were receiving therapy dan PRC transfusion during the four months following cancer diagnosis. Those with incomplete data or renal failure were excluded. The influence of these factors were analyzed with Chi-square or Fisher’s exact and Kolmogorov-Smirnov when iligible, and the most influential factor were analyzed by logistic regression. Out of 123 subjects receiving a PRC transfusion, 56 (45,5%) subjects received a PRC transfusion more than one times episodes. Higher episodes of transfusion were observed for patients whose bleeding (RR 6.940 (95%CI 2.563 to 18.790). Lower episodes of transfusion were observed for patients receiving transfusion previously and hematological malignancies, but the result were not significant (RR 0,524 (IK95% 0,057 – 4,852) and 0,464 (IK 95% 0,140 – 1,540) respectively). Bleeding is factor affecting transfusion episodes of PRC in children with malignancy.ABSTRAKTransfusi PRC merupakan terapi adjuvant yang sering digunakan pada anak dengan keganasan. Terdapat beberapa faktor yang memengaruhi episode transfusi sehingga penggunaan PRC rasional harus mempertimbangkan faktor tersebut. Penelitian ini bertujuan mengetahui faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan. Penelitian kohort retrospektif pada anak (0 –18 tahun) yang dirawat di RSUP Dr. Sardjito dengan penyakit keganasan yang telah terdiagnosis selama empat bulan dan mendapat terapi serta transfusi PRC sejak 1 Januari – 31 Desember 2015. Register tidak lengkap atau dengan gagal ginjal dieksklusi. Pengaruh faktor– faktor tersebut dianalisis dengan uji Chi-square atau uji Fisher serta Kolmogorov-Smirnov bila tidak memenuhi syarat, dan faktor yang paling berpengaruh dianalisis dengan uji logistic regression. Dari 123 subjek, 56 subjek dengan episode transfusi PRC > 1 kali. Keganasan hematologi, riwayat transfusi, dan perdarahan memengaruhi episode transfusi PRC > 1 kali. Analisis multivariat didapatkan perdarahan memengaruhi episode transfusi PRC > 1 kali (RR 6,940 (IK95% 2,563 – 18,790), namun riwayat transfusi dan keganasan hematologi tidak bermakna dengan nilai RR secara berturut-turut 0,524 (IK95% 0,057 – 4,852) dan 0,464 (IK 95% 0,140 – 1,540). Penelitian ini menyimpulkan bahwa perdarahan merupakan faktor yang memengaruhi episode transfusi PRC pada anak dengan keganasan.
Reflexões acerca da identidade do enfermeiro na gestão dos serviços de saúde
Authors: Santana Kelly Fernanda Silva , Marinho Mirna Neyara Alexandre de Sá Barreto , Cavalcante Ana Suelen Pedroza , Machado Lucas Dias Soares , Silva Lúcia de Fátima da , Guedes Maria Vilani Cavalcante , Freitas Maria Célia de , Silva Lucilane Maria Sales da
Published: May 2022

A identidade se caracteriza como um processo de construção de significados com diversos atributos culturais inter-relacionados, direcionando papéis sociais. No que tange a identidade profissional de enfermeiros, ela também se dá a partir da compreensão de seu lugar social e de como projetam essa construção no decorrer de sua trajetória acadêmica e profissional, e, no caso da gestão em saúde, almejando respostas às necessidades dos usuários. Refletir acerca da identidade profissional de enfermeiros gestores em saúde. Método: Trata-se de um estudo reflexivo, realizado em outubro de 2019, em que se realizou busca assistemática na literatura utilizando-se dos termos ‘identidade profissional’, ‘identidade profissional na enfermagem’ e ‘identidade profissional do gestor em saúde e do enfermeiro gestor em saúde’, em que as leituras das pesquisas condicionaram a construção de dois capítulos: ‘Identidade da profissão de enfermagem e da gestão em enfermagem – apropriando-se da história e dos conceitos’ e ‘Construindo a identidade profissional do enfermeiro gestor - da formação à prática’. O diferencial da identidade do enfermeiro no âmbito da gestão deve acontecer pela articulação entre a gerência do cuidado e a gestão de pessoas, processos e resultados. Para tanto, faz-se necessária uma reavaliação contínua dos processos e estratégias organizacionais das instituições formativas, por se tratar de um desafio definir as competências necessárias para a formação da identidade dos enfermeiros gestores. A identidade profissional do enfermeiro gestor é formada por reflexos de sua aprendizagem acadêmica dirigindo-se para os processos relacionais que envolvem o trabalho.
O cotidiano do gerenciamento na Atenção Primária à Saúde: percepções de gerentes
Authors: Condeles Pedro César , Mateus Lharissa Cristina , Bracarense Carolina Feliciana , Simões Ana Lúcia de Assis , Parreira Bibiane Dias Miranda , Goulart Bethania Ferreira
Published: May 2022

Objetivo: Investigar a percepção do gerenciamento nas Unidades de Saúde da Família, na perspectiva dos gerentes. Métodos: estudo exploratório, utilizando abordagem qualitativa. Participaram seis gerentes de Unidades supracitadas em um município em Minas Gerais. Para a coleta de dados utilizou-se entrevistas semiestruturadas, audio gravadas, de outubro a novembro de 2017, tendo em conta a pergunta de pesquisa: O que pensam os gerentes das Unidades de Saúde da Família, e como percebem o gerenciamento naquela circunstância? A verificação dos dados seguiu Análise de Conteúdo, modalidade Temática, e norteou-se seguindo os preceitos do processo de trabalho e de cogestão em saúde. Resultados: emergiram as seguintes categorias temáticas: Atribuição do gerente no cotidiano da APS; Gestão compartilhada; e, Desafios e Avanços para a gerência na APS. As referidas categorias mostraram elementos do cotidiano de trabalho dos gerentes nas unidades de saúde, bem como os desafios e os avanços neste cenário. Considerações Finais: Evidencia-se a importância da gestão compartilhada, com destaque para colaboração do enfermeiro da Estratégia Saúde da Família, o apoio e a comunicação da Secretaria Municipal de Saúde, e a especialização como ferramentas que poderão contribuir para a qualificação do processo de gerenciamento.
Análise imunoistoquímica e histomorfométrica do endométrio de ratas em estro permanente tratadas com melatonina, metformina e citrato de clomifeno
Authors: Mattos Leandro Sabará de , Lombardi Leonardo Augusto , Moura Marcio Luis Alves , Espindula Ana Paula , Simões Ricardo Santos , Florencio-Silva Rinaldo , Franco Paulo Celso , Sasso Gisela Rodrigues da Silva , Simões Manuel de Jesus
Published: May 2022

Objetivo: Avaliar os efeitos da melatonina, metformina e citrato de clomifeno no endométrio de ratas modelo de síndrome dos ovários policísticos. Métodos: Setenta e oito ratas foram divididas em 13 grupos e dois experimentos (prevenção e tratamento). Após as exposições todos os animais foram anestesiados e tiveram retirados os cornos uterinos e submetidos a coloração pela hematoxilina e eosina e imunoistoquímica (Ki-67 e Vegf). Os dados obtidos foram submetidos ao teste t de Student (p<0,05). Resultados/Conclusão: A melatonina, a metformina e o citrato de clomifeno não promovem efeitos proliferativos e angiogênicos no endométrio de ratas em estro permanente, porém, a melatonina tem efeito trófico mais significativo no estroma endometrial, o que não interferiu na sua espessura, enquanto que a metformina apresentou efeito trófico mais significante no epitélio glandular do endométrio, portanto, estes efeitos são semelhantes tanto antes quanto após a indução de SOP por exposição à luz contínua.
Qualidade físico-química do álcool em gel disponibilizado em estabelecimentos comerciais no município de Vitória da Conquista – BA durante o período de pandemia do COVID-19
Authors: Rodrigues Iasmin Cerqueira , Andrade Lorrana Hellen Gonçalves , Andrade Rafael França
Published: May 2022

Ao longo dos séculos, a raça humana exibiu um histórico de emergências sanitárias, epidemias que ficaram marcadas pela alta taxa de infecção e mortalidade. A mais recente, síndrome respiratória aguda grave (SARS-CoV-2), mais conhecida como COVID-19, as principais formas de prevenção recomendadas pelo Ministério da Saúde estão diretamente associadas às mãos, como evitar apertos de mãos e abraços, contato direto com olhos, nariz e boca, e, sobretudo lavá-la de forma frequente com água e sabão ou higienizar com álcool gel 70%. O álcool em gel tem a função de desnaturar proteínas, logo, soluções alcoólicas contendo o percentual de álcool de 70% são bastante efetivas, sendo concentrações menores ou maiores menos potentes. O objetivo deste estudo é analisar a qualidade físico-química do álcool em gel disponibilizado em estabelecimentos comerciais no município de Vitória da Conquista – BA durante o período de pandemia do COVID-19. Trata-se de um estudo exploratório, transversal e quantitativo realizado a partir da coleta de amostras de álcool em gel em cinco estabelecimentos comerciais. Avaliando a característica físico-química; propriedades organolépticas, pH, resistência a centrifugação, verificação do teor alcoólico e densidade. Sendo assim, observou-se que nenhuma das amostras se enquadravam nos parâmetros estabelecidos, como o pH mais ácido, teor alcoólico acima do ideal, densidade fora do padrão, apontando inconformidades que afetam a qualidade e ação do produto. Portanto conclui-se que, apenas uma elaboração de leis não seja suficiente para garantir a qualidade e segurança do produto, se faz necessário uma fiscalização mais rigorosa e elaboração de leis mais qualificadas.
Urban sharks: residency patterns of marine top predators in relation to a coastal metropolis
Authors: Hammerschlag N , Gutowsky LFG , Rider MJ , Roemer R , Gallagher AJ
Published: May 2022

Understanding and ultimately predicting how marine organisms will respond to urbanization is central for effective wildlife conservation and management in the Anthropocene. Sharks are upper trophic level predators in virtually all marine environments, but if and how their behaviors are influenced by coastal urbanization remains understudied. Here, we examined space use and residency patterns of 14 great hammerheads Sphyrna mokarran, 13 bull sharks Carcharhinus leucas, and 25 nurse sharks Ginglymostoma cirratum in proximity to the coastal metropolis of Miami, Florida, using passive acoustic telemetry. Based on the terrestrial urban carnivore literature, we predicted sharks would exhibit avoidance behaviors of areas close to Miami, with residency patterns in these urban areas increasing during periods of lower human activity, such as during nocturnal hours and weekdays, and that dietary specialists (great hammerhead) would exhibit comparatively lower affinity towards highly urbanized areas relative to dietary generalists (bull and nurse shark). However, we did not find empirical support for these predictions. Space use patterns of tracked sharks were consistent with that of ‘urban adapters’ (species that exhibit partial use of urban areas). Modeling also revealed that an unmeasured spatial variable was driving considerable shark residency in areas exposed to high urbanization. We propose several hypotheses that could explain our findings, including food provisioning from shore-based activities that could be attracting sharks to urban areas. Ultimately, the lack of avoidance of urban areas by sharks documented here, as compared to terrestrial carnivores, should motivate future research in the growing field of urban ecology.
Perspectives on Treatment of Inflammatory Bowel Disease in Older Patients: Applying Gut-Feeling in an Evidence-Based Era?
Authors: Asscher Vera E.R. , Verbiest Cynthia M. , Waars Sanne N. , Mooijaart Simon P. , van der Meulen-de Jong Andrea E. , Pieterse Arwen H. , Maljaars P.W. Jeroen
Published: May 2022

Background: The older inflammatory bowel disease (IBD) population is challenging to treat because of heterogeneity in characteristics related to frailty. The authors aimed to study factors contributing to the difference in treatment between older and younger patients with IBD and the relation between frailty and therapy goals, from the perspectives of both professionals and patients with IBD.

Methods: Semi-structured interviews in 15 IBD professionals and 15 IBD patients aged ≥65 years.

Results: Professionals had 1–20 years of experience, and three practiced in an academic hospital. Patients were aged 67–94 years and had a disease duration between 2 years and 62 years. The authors found that professionals aimed more often for clinical remission and less often for endoscopic remission in older compared with younger patients. Older patients also aimed for clinical remission, but valued objective confirmation of remission as a reassurance. Professionals sometimes opted for surgery earlier in the treatment course, while older patients aimed to prevent surgery. Professionals’ opinion on corticosteroids in older patients differed, while patients preferred to avoid corticosteroids. In professionals and patients, there was a shift towards goals related to frailty in patients with frailty. However, professionals did not assess frailty systematically, but judged frailty status by applying a clinical view.

Conclusions: Many therapy goals differed between older and younger patients, in both professionals and patients. Professionals did not assess frailty systematically, yet aspects of frailty influenced therapy goals. This underlines the need for clinically applicable evidence on frailty in IBD, which could aid tailored treatment.
A Covid-19-pandémia hatása az evészavarokra
Authors: Babusa Bernadett , Túry Ferenc
Published: May 2022

A Covid-19-pandémia során több pszichiátriai kórkép vált gyakoribbá, a többi között az evészavarok esetében is. Növekedett az anorexia nervosa és a bulimia nervosa, valamint egyéb evészavartünetek incidenciája. Emellett súlyosbodtak a tünetek és nagyobb lett a relapszus aránya is. Mindezek hátterében a következő tényezők szerepelhetnek: megváltozott az étel elérhetősége; fokozódott a félelem az elhízástól, hangsúlyossá vált a közösségi média és egyes internetes oldalak szerepe az izoláció következtében, kifejezettebb lett a társas összehasonlítás; korlátozottak voltak a sportolási lehetőségek; növekedett a stresszkeltő életesemények hatása, például a családi feszültségeké. A pandémia mentális következményei a táplálkozási magatartás terén is a pszichoedukáció, az elsődleges és másodlagos prevenció fontosságára hívják fel a figyelmet.
PENERAPAN PRINSIP CONTINUOUS IMPROVEMENT DALAM TOTAL QUALITY MANAGEMENT UNTUK MENINGKATKAN MUTU PENDIDIKAN
Authors: Suaeb Suaeb
Published: May 2022

Penelitian ini bertujuan untuk menganalisis penerapan prinsip continuous improvement dalam Total Quality Management (TQM) untuk meningkatkan mutu pendidikan di Sekolah Menengah Kejuruan Negeri 1 Kota Bima. Penelitian menggunakan pendekatan kualitatif. Jenis data terdiri dari data primer dan data sekunder. Teknik pengumpulan data menggunakan observasi, wawancara dan studi dokumentasi. Analisis data menggunakan model interaktif data analisis, yaitu: data reduction, data display, dan verifikasi (conclusions). Uji keabsahan data penelitian menggunakan teknik triangulasi. Hasil penelitian menemukan bahwa penerapan prinsip continuous improvement diwujudkan melalui perbaikan pada empat dimensi, yaitu: (1) dimensi manajemen organisasi; (2) dimensi administrasi dan keuangan; (3) dimensi sumber daya; dan (4) dimensi pembelajaran. Temuan penelitian ini memberi arah masa depan bahwa adopsi prinsip mutu menjadi bagian integral dari usaha peningkatan mutu pendidikan. Penelitian yang akan datang diharapkan mengkaji lebih lanjut model manajemen mutu yang lebih canggih dari yang telah dipelajari dalam penelitian ini.
GEOMETRIA NO ENSINO FUNDAMENTAL: UMA ATIVIDADE EM ESPAÇO FORMAL E NÃO FORMAL
Authors: Machado Rosana de Souza , Dorow Thais Scotti do Canto , Leivas José Carlos Pinto
Published: May 2022

Este artigo apresenta resultados de uma atividade realizada no sétimo ano do Ensino Fundamental, que teve como objetivo investigar como os alunos visualizam, reconhecem e classificam formas geométricas planas ao explorarem um ambiente não formal. A fundamentação teórica foi baseada no modelo de desenvolvimento do raciocínio em Geometria de VanHiele. Essa atividade é parte de uma pesquisa que possui o diferencial de que a coleta de dados foi realizada em espaço não formal e, posteriormente, trazida para o espaço formal da sala de aula. Considerando que o desenvolvimento da Ciência Matemática, em particular da Geometria, tem a finalidade de contribuir para a construção do conhecimento matemático, já na primeira fase da escolarização, entende-se que o objetivo de visualizar, reconhecer e classificar formas geométricas planas, ao explorar um ambiente não formal, subsidia o ensino e promove a construção do conhecimento matemático/geométrico. Os resultados mostraram que o reconhecimento de formas geométricas planas, encontradas em um espaço não formal, na natureza e nas construções humanas, permitiram o avanço em níveis do modelo, inclusive, resgatando alunos que não apresentavam rendimento satisfatório em aulas convencionais. Muito embora formas geométricas planas sejamconstrutos mentais, visualizá-las e reconhecer suas propriedades em um ambiente concreto permitiram à professora ensinar outros conteúdos de Geometria, com melhor aprendizagem dos alunos do que em anos anteriores, apenas em sala de aula.
Disease Impact, Diagnostic Delay, and Unmet Medical Needs of Patients With Cholinergic Urticaria in German-Speaking Countries
Authors: Altrichter Sabine , Mellerowicz Emilia , Terhorst-Molawi Dorothea , Grekowitz Eva , Weller Karsten , Maurer Marcus
Published: May 2022

Background

Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria. Little is known about the burden of the disease and its unmet medical needs.

Aim

To characterize the unmet medical needs of patients with CholU.

Methods

Patients with CholU (n = 111) took part in a German online survey that assessed their symptoms, diagnostic delay, impact on daily life, quality of life (QoL), and their experience with physician care.

Results

Virtually all patients reported typical signs and symptoms of CholU, i.e., whealing (93.7%) and itching (91.9%), in response to typical trigger situations, such as physical activity, passive warming, or stress. Despite this, patients reported a marked diagnostic delay of 30.2 months (range from 0 to 279 months). Only 38% of the patients received a blood examination, and only 16% underwent provocation testing for diagnosing CholU, as recommended by the international guidelines. Physician contacts were common, but patient satisfaction with their disease management was low. In total, 90.1% of the patients stated to have an uncontrolled disease, resulting in a strong impact on their everyday activities, sleep, and QoL.

Conclusion

Patients with CholU exhibit many important unmet needs, and improvement in the diagnostic workup and patient care is needed, as are better treatment options.
Conclusion or Illusion: Quantifying Uncertainty in Inverse Analyses From Marker-Based Motion Capture due to Errors in Marker Registration and Model Scaling
Authors: Uchida Thomas K. , Seth Ajay
Published: May 2022

Estimating kinematics from optical motion capture with skin-mounted markers, referred to as an inverse kinematic (IK) calculation, is the most common experimental technique in human motion analysis. Kinematics are often used to diagnose movement disorders and plan treatment strategies. In many such applications, small differences in joint angles can be clinically significant. Kinematics are also used to estimate joint powers, muscle forces, and other quantities of interest that cannot typically be measured directly. Thus, the accuracy and reproducibility of IK calculations are critical. In this work, we isolate and quantify the uncertainty in joint angles, moments, and powers due to two sources of error during IK analyses: errors in the placement of markers on the model (marker registration) and errors in the dimensions of the model’s body segments (model scaling). We demonstrate that IK solutions are best presented as a distribution of equally probable trajectories when these sources of modeling uncertainty are considered. Notably, a substantial amount of uncertainty exists in the computed kinematics and kinetics even if low marker tracking errors are achieved. For example, considering only 2 cm of marker registration uncertainty, peak ankle plantarflexion angle varied by 15.9°, peak ankle plantarflexion moment varied by 26.6 N⋅m, and peak ankle power at push off varied by 75.9 W during healthy gait. This uncertainty can directly impact the classification of patient movements and the evaluation of training or device effectiveness, such as calculations of push-off power. We provide scripts in OpenSim so that others can reproduce our results and quantify the effect of modeling uncertainty in their own studies.
Greening Construction Transport as a Sustainability Enabler for New Zealand: A Research Framework
Authors: Dhawan Kamal , Tookey John E. , GhaffarianHoseini Ali , GhaffarianHoseini Amirhosein
Published: May 2022

The construction industry’s inherent fragmentation fuels Construction Supply Chain (CSC) complexity. Logistics form an essential part of the CSC in terms of costs and project management. In turn, transportation accounts for more than half the logistics costs due to construction materials being low-cost/high-volume, and most other logistics processes being business processes and not physical ones. Construction transport is almost entirely road bound, one of the least sustainable modes with externalities far out of proportion to its numbers. Ergo, its optimisation presents substantial greening (de-carbonisation) opportunity, with potentially far-reaching sustainability impacts. The ASI (Avoid-Shift-Improve) concept considers activity, modal structure, and energy intensity/efficiency as transport carbon components, providing a fundamental optimisation framework. 93% of New Zealand’s freight (a third of it construction related) is road bound, with 99% fossil-fuel (diesel) dependence. Government adoption of ASI elementsvizSupply Chain (SC) efficiency, transport optimisation, data/information sharing, and collaboration for transport decarbonisation aligns with Industry 5.0, but seeks further research for concrete implementation pathways. This paper aims to bridge the gap by proposing a research framework for greening of construction transport as a sustainability enabler for New Zealand.
Multi-Omics Analysis of MCM2 as a Promising Biomarker in Pan-Cancer
Authors: Yuan Jing , Lan Hua , Huang Dongqing , Guo Xiaohui , Liu Chu , Liu Shuping , Zhang Peng , Cheng Yan , Xiao Songshu
Published: May 2022

Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal maintenance family of proteins that mainly regulates DNA replication and the cell cycle and is involved in regulating cancer cell proliferation in various cancers. Previous studies have reported that MCM2 plays a pivotal role in cell proliferation and cancer development. However, few articles have systematically reported the pathogenic roles of MCM2 across cancers. Therefore, the present pan-cancer study was conducted. Various computational tools were used to investigate the MCM2 expression level, genetic mutation rate, and regulating mechanism, immune infiltration, tumor diagnosis and prognosis, therapeutic response and drug sensitivity of various cancers. The expression and function of MCM2 were examined by Western blotting and CCK-8 assays. MCM2 was significantly upregulated in almost all cancers and cancer subtypes in The Cancer Genome Atlas and was closely associated with tumor mutation burden, tumor stage, and immune therapy response. Upregulation of MCM2 expression may be correlated with a high level of alterations rate. MCM2 expression was associated with the infiltration of various immune cells and molecules and markedly associated with a poor prognosis. Western blotting and CCK-8 assays revealed that MCM2 expression was significantly upregulated in melanoma cell lines. Our results also suggested that MCM2 promotes cell proliferation in vitro by activating cell proliferation pathways such as the Akt signaling pathways. This study explored the oncogenic role of MCM2 across cancers, provided data on the underlying mechanisms of these cancers for further research and demonstrated that MCM2 may be a promising target for cancer immunotherapy.
Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years
Authors: Ehata Shogo , Miyazono Kohei
Published: May 2022

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β) family, are multifunctional cytokines. BMPs have a broad range of functions, and abnormalities in BMP signaling pathways are involved in cancer progression. BMPs activate the proliferation of certain cancer cells. Malignant phenotypes of cancer cells, such as increased motility, invasiveness, and stemness, are enhanced by BMPs. Simultaneously, BMPs act on various cellular components and regulate angiogenesis in the tumor microenvironment. Thus, BMPs function as pro-tumorigenic factors in various types of cancer. However, similar to TGF-β, which shows both positive and negative effects on tumorigenesis, BMPs also act as tumor suppressors in other types of cancers. In this article, we review important findings published in the recent decade and summarize the pro-oncogenic functions of BMPs and their underlying mechanisms. The current status of BMP-targeted therapies for cancers is also discussed.
Fungal Infections as an Uprising Threat to Human Health: Chemosensitization of Fungal Pathogens With AFP From Aspergillus giganteus
Authors: Dhandapani Kavitha , Sivarajan Karthiga , Ravindhiran Ramya , Sekar Jothi Nayaki
Published: May 2022

Occurrence and intensity of systemic invasive fungal infections have significantly risen in recent decades with large amount of mortality and morbidity rates at global level. Treatment therapy lies on the current antifungal interventions and are often limited due to the emergence of resistance to antifungal agents. Chemosensitization of fungal strains to the conventional antimycotic drugs are of growing concern. Current antifungal drugs often have been reported with poor activity and side effects to the host and have a few number of targets to manifest their efficacy on the pathogens. Indiscriminately, the aforementioned issues have been easily resolved by the development of new intervention strategies. One such approach is to employ combinational therapy that has exhibited a great level of inhibitions than that of a single compound. Chemosensitization of pathogenic mycoses to commercial antifungal drugs could be drastically enhanced by co-application of chemosensitizers along with the conventional drugs. Chemosensitizers could address the resistance mechanisms evolved in the pathogenic fungi and targeting the system to make the organism susceptible to commercially and clinically proven antifungal drugs. However, this strategy has not been overreached to the greater level, but it needs much attention to fight against not only with the pathogen but combat the resistance mechanisms of pathogens to drugs. Natural compounds including plant compounds and microbial proteins act as potential chemosensitizers to break the resistance in mycoses. Aspergillus giganteus, a filamentous fungus, is known to produce a cysteine rich extracellular protein called as antifungal protein (AFP). AFP has shown enhanced efficacy against several filamentous and non-filamentous fungal pathogens. On the basis of the reported studies on its targeted potential against pathogenic mycoses, AFP would be fabricated as a good chemosensitizer to augment the fungicidal efficacy of commercial antimycotic drugs. This paper reviews on breakthrough in the discovery of antifungal drugs along with the resistance patterns of mycoses to commercial drugs followed by the current intervention strategies applied to augment the fungicidal potential of drugs.
S2 Heart Sound Detects Aortic Valve Calcification Independent of Hemodynamic Changes in Mice
Authors: Dargam Valentina , Ng Hooi Hooi , Nasim Sana , Chaparro Daniel , Irion Camila Iansen , Seshadri Suhas Rathna , Barreto Armando , Danziger Zachary C. , Shehadeh Lina A. , Hutcheson Joshua D.
Published: May 2022

Background

Calcific aortic valve disease (CAVD) is often undiagnosed in asymptomatic patients, especially in underserved populations. Although artificial intelligence has improved murmur detection in auscultation exams, murmur manifestation depends on hemodynamic factors that can be independent of aortic valve (AoV) calcium load and function. The aim of this study was to determine if the presence of AoV calcification directly influences the S2 heart sound.

Methods

Adult C57BL/6J mice were assigned to the following 12-week-long diets: (1) Control group (n = 11) fed a normal chow, (2) Adenine group (n = 4) fed an adenine-supplemented diet to induce chronic kidney disease (CKD), and (3) Adenine + HP (n = 9) group fed the CKD diet for 6 weeks, then supplemented with high phosphate (HP) for another 6 weeks to induce AoV calcification. Phonocardiograms, echocardiogram-based valvular function, and AoV calcification were assessed at endpoint.

Results

Mice on the Adenine + HP diet had detectable AoV calcification (9.28 ± 0.74% by volume). After segmentation and dimensionality reduction, S2 sounds were labeled based on the presence of disease: Healthy, CKD, or CKD + CAVD. The dataset (2,516 S2 sounds) was split subject-wise, and an ensemble learning-based algorithm was developed to classify S2 sound features. For external validation, the areas under the receiver operating characteristic curve of the algorithm to classify mice were 0.9940 for Healthy, 0.9717 for CKD, and 0.9593 for CKD + CAVD. The algorithm had a low misclassification performance of testing set S2 sounds (1.27% false positive, 1.99% false negative).

Conclusion

Our ensemble learning-based algorithm demonstrated the feasibility of using the S2 sound to detect the presence of AoV calcification. The S2 sound can be used as a marker to identify AoV calcification independent of hemodynamic changes observed in echocardiography.
Mineral-specific Quantitative Element Mapping Applied to Visualization of Geochemical Variation in Glauconitic Clasts
Authors: Keulen Nynke , Weibel Rikke , Malkki Sebastian N.
Published: May 2022

The geochemical composition of glauconitic clasts is a provenance marker to distinguish the origin of gravity flows in sedimentary basins. Their geochemical variation is visible in major and trace elements composition, where the former can be visualized by element mapping of glauconitic clasts. By applying automated quantitative mineralogy on a Scanning Electron Microscope equipped with the ZEISS Mineralogic™ software platform, we developed a new way to visualize the element distribution in selected minerals, while masking out the other minerals simultaneously. This software applies energy dispersive spectroscopy spectrum deconvolution for each analysis point, therefore quantitative concentrations (wt%) of each element are determined for each pixel and visualized in the false-coloured element map with reproducible results for individual grains and zonations in these grains. The investigated glauconitic clasts were collected from eleven drill cores, covering a 1400 m-depth interval, and crosscutting four different gravity flow members. The clasts show three different trends: first, cores of glauconitic clasts show a variation of compositions that are mainly dependent on the conditions during their formation. This is most visible for Si and Al. Secondly, the composition of the glauconitic clasts changes with depth, their cores become first more, than less Fe-rich and more K-rich. This is probably an alteration effect, depending on temperature, and therefore mineral stability. And, thirdly, most glauconitic clasts are zoned, where rims are richer in Al and poorer in Fe and K. The visualization of the chemical variation in the glauconitic clasts proofs to be a useful tool to separate these conflicting element exchange processes.
Effects of Lithospheric Properties on Crustal Strain at Both Ends of Longmen Shan Orogenic Belt: Based on Numerical Simulation
Authors: Shen Tuo , Xu Xiwei , Li Yujiang , Huang Luyuan , Rogozhin E. A. , Wang Qixin , Kang Wenjun , Lei Xiaoqiong
Published: May 2022

Strain partitioning and accommodation are fundamental constraints to evaluate tectonic models of orogenic plateaus. The uplift mechanism issue of the eastern Tibetan Plateau has remained a long-term focus since the last century, namely, the steep uplift of the Longmen Shan area. Several tectonic models have been proposed to describe the uplift process of the central Longmen Shan area along the eastern margin of the Tibetan Plateau. Such as upper crustal shortening, mid-crustal channel flow, and whole-crust shearing. However, these models are typically examined through vertical differences. Geophysical, geological, remote sensing and geochemistry observation data indicate that there occur not only vertical differences but also obvious horizontal differences along the Longmen Shan orogenic belt. Based on the finite element method, we employed two-dimensional profiles crossed northern and southern Longmen Shan fault to reconstruct the uplift process of the Longmen Shan orogenic belt. The mechanical properties of the lithosphere south of the Longmen Shan orogenic belt were slightly less favorable than those of the lithosphere north of the Longmen Shan orogenic belt. For the better fitting result in the southern part viscosity of lower crust is less than 1021 Pa∙s and in the northern part viscosity of lower crust is around 1022 Pa∙s. The uplift processes in the upper and lower crust of the Longmen Shan orogenic belt were partially decoupled. The deformation of lithosphere in the northern Longmen Shan orogenic belt is smaller than it in southern Longmen Shan orogenic belt. Due to that the rigid Ruoergai block maybe resists the formation of a weak layer or enters of weak materials to the northern Longmen Shan block, resulting in the observed difference in lithospheric properties between the northern and southern Longmen Shan blocks.
Medial Turn in Education: Philosophy of Understanding Words and Images
Authors: Grigoryev Sergey L. , Saenko Natalya R. , Volkova Polina S. , Kortunov Vadim V.
Published: May 2022

The research presented in the article aimed to diagnose the profound changes that have taken place in education as a result of the expansion of screen technologies and the introduction of distance interaction in pedagogy. The live-sounding speech of a teacher is the true historical form of paideia as such and the technique of maieutics in particular. Any intermediary, even a writing process, let alone the screen, reduces the effect of pedagogical dialog and produces significant and radical changes in the understanding of meaning. The article deals with the problems of understanding in the pressing context of two turns of educational philosophy: linguistic and medial. The empirical background of these turns is represented, on the one hand, by the increasing extent of the visualized (“printed,” “screened”) word in educational procedures vs. the sounding word, and by the irreversible introduction of screen technologies, digitalization, and distance learning, on the other hand. The consideration is made through the prism of the comprehension-based approach focusing on the values and meanings of professional-pedagogical activity, namely, the systemic approach, the principles of language sign ambivalence, the method of stylistic decoding, the method of analysis of vocabulary definitions, and intertextuality.
Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction
Authors: Xiong Yang , Zhong Xin , Zhang Fuxun , Wang Wei , Zhang Yangchang , Wu Changjing , Qin Feng , Yuan Jiuhong
Published: May 2022

Background

The association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study.

Materials and Methods

The single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED.

Results

Snoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.68 - 7.09, P < 0.001) in the inverse variance weighting estimator. In sensitivity analyses, the ORs for the weighted median, MR robust adjusted profile score, and MR Pleiotropy Residual Sum and Outlier approach, MR-Egger, and maximum likelihood method are 5.70 (95% CI = 1.19 - 27.21, P < 0.05), 3.14 (95% CI = 1.01 - 9.72, P < 0.05), 3.11 (95% CI = 1.63 - 5.91, P < 0.01), 1.23 (95% CI = 0.01 – 679.73, P > 0.05), and 3.59 (95% CI = 1.07 – 12.00, P < 0.05), respectively. No heterogeneity and pleiotropy are observed (P for MR-Egger intercept = 0.748; P for global test = 0.997; P for Cochran’s Q statistics > 0.05). After adjusting for total cholesterol, triglyceride, low-density lipoprotein, and cigarette consumption, the ORs for ED are 5.75 (95% CI = 1.80 - 18.34, P < 0.01), 4.16 (95% CI = 1.10 - 15.81, P < 0.05), 5.50 (95% CI = 1.62 - 18.69, P < 0.01), and 2.74 (95% CI = 1.06 - 7.10, P < 0.05), respectively.

Conclusion

This study provides genetic evidence supporting the causal role of snoring in ED.
Review on Evolution of Intelligent Algorithms for Transformer Condition Assessment
Authors: Wang Jian , Zhang Xihai , Zhang Fangfang , Wan Junhe , Kou Lei , Ke Wende
Published: May 2022

Transformers are playing an increasingly significant part in energy conversion, transmission, and distribution, which link various resources, including conventional, renewable, and sustainable energy, from generation to consumption. Power transformers and their components are vulnerable to various operational factors during their entire life cycle, which may lead to catastrophic failures, irreversible revenue losses, and power outages. Hence, it is crucial to investigate transformer condition assessment to grasp the operating state accurately to reduce the failures and operating costs and enhance the reliability performance. In this context, comprehensive data mining and analysis based on intelligent algorithms are of great significance for promoting the comprehensiveness, efficiency, and accuracy of condition assessment. In this article, in an attempt to provide and reveal the current status and evolution of intelligent algorithms for transformer condition assessment and provide a better understanding of research perspectives, a unified framework of intelligent algorithms for transformer condition assessment and a survey of new findings in this rapidly-advancing field are presented. First, the failure statistics analysis is outlined, and the developing mechanism of the transformer internal latent fault is investigated. Then, in combination with intelligent demands of the tasks in each stage of transformer condition assessment under big data, we analyze the data source in-depth and redefine the concept and architecture of transformer condition assessment. Furthermore, the typical methods widely used in transformer condition assessment are mainly divided into rule, information fusion, and artificial intelligence. The new findings for intelligent algorithms are also elaborated, including differentiated evaluation, uncertainty methods, and big data analysis. Finally, future research directions are discussed.