bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Ensemble Assimilation System for Forecasting the Genesis of Tropical Cyclone Sonca (2017) in the Vietnam East Sea using a Lagrangian Approach
Authors: Hoa Dao Nguyen Quynh
Published: September 2023

: With the aim of evaluating the cyclogenesis predictability of Sonca (2017) using an ensemble prediction system from the local ensemble transform Kalman filter (LETKF) to model WRF, the study proposed a dynamical assessment method with a Lagrangian approach that is stable and independent of time and reference systes. With this approach, the study can clearly distinguish between cases of tropical cyclone (TC) formation and non-formation in the ensemble forecast members. By evaluating the thermodynamic conditions of the low-level circulation between the forming and non-forming groups, the study found that the ocean-atmosphere interaction and the vortex merger process play imnportant roles in the formation of Sonca. The evaluation of the formation location showed that the detected vortex centers from the forming members tended to concentrate near the monsoon trough axis, indicating that this is a highly favorable region for vortex formation in the Vietnam East Sea.
Recommender systems in education: A literature review and bibliometric analysis
Authors: Lampropoulos Georgios
Published: September 2023

This study aims to provide an overview regarding the use of recommender systems in education through a systematic review and a bibliometric analysis. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed and a total of 1,622 related documents from Scopus and WoS are examined from 2001 to 2022. The study goes over the literature and describes personalized learning, artificial intelligence (AI) in education as well as recommender systems and educational recommender systems. Besides descriptive statistics about the document collection, the result analysis involves the citation, sources, authors, affiliations, countries, and document information and categories of the related articles. The thematic evolution of the topic throughout the years is also examined. Based on the results, the recency and significance of recommender systems and their potentials in the educational domain were evident. Their ability to take into account learners' unique traits, experiences, skills, and preferences was highlighted. Recommender systems emerged as a learning tool that can empower learners, improve education quality and learning outcomes, increase learners' motivation, engagement, achievements, and satisfaction, and enable learners to be in charge of their own learning. Finally, recommender systems arose as an effective educational tool that can promote and improve adaptive learning and personalized learning.
Termografía infrarroja en la evaluación mamaria: un estudio piloto en mujeres en edad fértil
Authors: Londoño Orozco Mariana , Ospina Suárez Anngie Carolina , Segura Giraldo Belarmino
Published: September 2023

La termografía infrarroja ha resaltado como una técnica prometedora para la detección no invasiva de anomalías en los tejidos mamarios, al reflejar cambios en la emisión de calor y patrones de temperatura. Este artículo presenta una propuesta de protocolo para la captura de imágenes termográficas mamarias en mujeres en edad fértil, con el objetivo de mejorar la evaluación y el diagnóstico en esta población. Para desarrollar esta investigación, se llevó a cabo una revisión bibliográfica en diversas bases de datos científicas, considerando factores relevantes como el tipo de estudio, la población de interés, las variables medidas y los resultados obtenidos. Se desarrolló una herramienta computacional para el procesamiento de las imágenes termográficas, que fueron obtenidas siguiendo un protocolo propuesto, el cual, es derivado de la vigilancia tecnológica comentada en este documento. La metodología utilizada incluye criterios de exclusión para seleccionar adecuadamente los pacientes, instrucciones precisas para la preparación del paciente antes del examen, y consideraciones sobre el entorno del examen para asegurar la precisión de las mediciones termográficas. Asimismo, se estableció un procedimiento específico para la captura de las imágenes, utilizando un soporte diseñado para posicionar los pacientes frente a la cámara termográfica. Finalmente, el procesamiento de las imágenes termográficas obtenidas permitió distinguir una frontera entre los días del ciclo menstrual de las mujeres evaluadas, de donde se presume que no existe diferencia representativa entre la temperatura corporal durante el ciclo menstrual.
Functional, nutritional, and technological potential of quinoa through lactic acid fermentation: a review
Authors: Benavides Ruth Mary , Rodríguez Ibeth , Inampués María
Published: September 2023

Quinoa is an ancestral Andean grain of great importance due to its nutritional potential, cultivated in the Andean region for many years. Lactic acid fermentation may be a cost-effective processing alternative to improve quinoa-derived or gluten-free products, as it has been used in different cereals to enhance physicochemical and sensory characteristics. This review presents the nutritional importance of quinoa, the key indicators that can affect homofermentation, the analysis of different studies that have worked with this pseudocereal as a substrate for the development of various fermented products such as sourdoughs from quinoa flour for bread and other baked goods, beverages, pasta, baked products in combination with other pseudocereals and buckwheat, and soy-based beverages. The results reveal that quinoa is a nutrient-rich substrate for lactic acid bacteria, and fermentation generates nutritional changes by increasing certain macronutrients and/or bioactive compounds through bacterial metabolism and starch hydrolysis. Additionally, it improves functional, technological, and sensory properties due to starch modification and metabolite production. This presents a promising alternative in quinoa processing and the development of functional foods.
Metodologías para la evaluación de la eficiencia energética en edificaciones universitarias: Revisión literaria.
Authors: Gonzalez Salcedo Luis Octavio , Araujo Badiel Andrea Viviana , Mejía Carmona Diego Fernando
Published: September 2023

Diversos factores, así como el uso y tipo de actividades que se desarrollan en las edificaciones, tienen un rol importante en su eficiencia y comportamientos energéticos. La consideración y conocimiento de estos factores, usos y actividades, son necesarias para proponer acciones que ayuden a mejorar su desempeño energético y aplicar soluciones integradas a sus necesidades. Diversas metodologías se emplean para evaluar el comportamiento y eficiencia energética de los mismos. Sin embargo, para las edificaciones universitarias las metodologías convencionales requieren ser ajustadas para su correcta aplicación. Esta contribución presenta una revisión literaria sobre las metodologías para la evaluación de la eficiencia energética en edificaciones universitarias, la cual fue llevada a cabo usando una metodología orientada hacia los análisis bibliográfico y bibliométrico, respectivamente. La revisión permitió concluir que las metodologías para tal fin, corresponden principalmente a auditorías, modelación y simulación, evaluaciones comparativas, y mediciones avanzadas.
Saúde mental do médico e dos estudantes de medicina
Authors: Rister Gilmara Peixoto , Tostes Mauricio de Assis
Published: September 2023

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Histopathological Effects of Supercypermethrin in Liver of Albino rats
Authors: Ali–Duliami Liqaa  Hussain
Published: September 2023

Histopathological alterations histochemistry and Biochemical parameters were used to assess the toxicity of the commercial pesticide (cypermethrin) on the liver tissue of male albino rats. 48 rats were used in this study. Each set of six rats was separated into four groups in the acute experiment. The control group was subcutaneously injected with distilled water, while the other three were injected subcutaneously with the insecticide at different concentrations (0.050, 0.025, 0.10). At these different concentrations, acute toxicity was assessed. A)er 24 hours, the mortality rate and poisoning signs increased with the increase in the concentration of the pesticide. As for the subacute toxicity experiment, 4 groups were used in this experiment with 6 animals in each. a control group injected with distilled water only, and another group injected with 0.025  as a single daily dose for 10, 20, and 30 days, respectively.  This pesticide In the three separate times, caused some histopathological and biochemical changes in the treated groups in liver tissues and some biochemical changes in liver function were recorded, including Alanine Transaminase(ALT), Aspartate Transaminase (AST), and the levels of protein were measured in the serum. The researchers determined that cypermethrin has acute and subacute toxic effects, which manifested as alterations in serum enzymes and histopathological abnormalities in liver tissue.
Capabilities of Blended Learning as a Teaching and Learning Tool in Tikrit University
Authors: Ibraheem Abdullah
Published: September 2023

In early 2022, After the COVID-19 pandemic, many universities around the world, especially Iraqi universities, continued offering online courses based on a blended learning approach that supporting by traditional learning. The growing demand and popularity of mixed-learning models in higher education has made them a widespread educational phenomenon. However, most of the literature focus on blended learning design techniques only without considering interrelated key components for user needs and how to design blended learning based on user interaction (UI), user experience (UX), and different cultures and languages of learners. Therefore, this research aims to the evaluation of BL at Tikrit University based on the needs, and interactions of students in the learning process. Therefore, This study is an experimental study based on questionnaires distributed to 180 students from different colleges at Tikrit University. Finally, the results show that learning and acquiring skills and knowledge through BL is preferable to learning through traditional classrooms.
AN EXPLORATORY STUDY ON STUDENTS’ ANXIETY IN THE PROCESS OF COMPOSING AN ENGLISH ESSAY
Authors: Achmad Diana , Aulia Muhammad , Hidayatullah Roni Ageng , Yusuf Yunisrina Qismullah
Published: September 2023

Writing proficiency is a crucial language skill for students to acquire, necessitating the production of compositions such as essays. This research aims to identify the manifestations of anxiety experienced by students during the composition of English essays and to ascertain the underlying factors precipitating such apprehension. Participants consisted of 34 fifth-semester students from the Department of English Education at Universitas Syiah Kuala. Employing qualitative methodology, the study utilized questionnaires and interviews as research instruments to collect data. Questionnaires were used to capture data concerning diverse forms of student anxiety, while interviews were conducted to elucidate the determinants of anxiety specifically related to composing English essays. Outcomes revealed that cognitive anxiety was predominant, afflicting 43.5% of fifth-semester students, showcasing its prevalence in this cohort. Additionally, language complexities, self-confidence deficits, fear of critical evaluation, and the pursuit of perfection emerged as pivotal sources of essay-writing apprehension. These findings underline the multifaceted nature of student anxiety during English essay composition, thereby serving as a valuable resource for educational stakeholders seeking insights to enhance students' writing competencies.
Obsolete Words in Russian Translations of «The Song of Roland»
Authors: Kuznetsova M. A.
Published: September 2023

A whole range of topical scientific issues is associated with the concept of obsolete vocabulary: criteria for selecting obsolete vocabulary, the concept of archaism, the distinction between artificial and natural archaization, the problem of mixing obsolete vocabulary with words of poetic and bookish styles.

   The purpose of this work is to compare and classify Russian translations of «The Song of Roland» in terms of various types of obsolete vocabulary occurring in them, to quantify the frequency of the latter and interpret these facts with regard to translation strategies.

   For our study we used some fragments of Russian translations corresponding to the LII-LVI laisses in F. Michel’s version of the poem, published in 1837. In our article, we use the term obsolete vocabulary in relation to archaisms and historicisms. When describing archaisms, we were guided by P. Zumthor’s classification . Our selection of obsolete vocabulary was based on the presence of corresponding marks in the following dictionaries: S. I. Ozhegov 1986, D. N. Ushakov 1935 - 1940, the Small Academic Dictionary of 1999. The largest number of obsolete words was found in B. I. Yarkho’s translation – 58 instances. Next comes the translation of the count F. de La Barthes – 54 instances. Then follows B. N. Almazov’s translation – 53 obsolete lexical units and Yu. B. Korneev’s translation – 51. The smallest number of obsolete words was found in A. N. Chudinov’s translation – 43 examples. Historicisms (116 units) turned out to be the most frequent in translations, slightly less frequent are lexical archaisms (95 units), next in frequency are grammatical archaisms (21 units), then come phonetical-graphic archaisms (19 units), syntactic archaisms (5 units) and syntagmatic ones (3 units). In addition, the ratio of archaisms and historicisms is not directly related to the time of creation of the translation, nor is it directly related to the frequency of obsolete vocabulary in general. This suggests that translation decisions are determined by the authors’ personal choice rather than by external factors.
The Lexico-Semantic Field of Post-Truth in Socio-Political Discourse
Authors: Fefelov A. F.
Published: September 2023

The purpose of the review article is to identify conceptualizations of the post-truth era in the English-language socio-political communication, based on the key vocabulary of a number of reviews and sources representing the component post-truth in the media. The object of the analysis is lexical representation of the component post-truth in the media. The subject matter of the analysis is conceptual interpretation of the post-truth component in such relevant phrases as post-truth era (or politics, world of politics, politicians, society, age, knowledge and power, condition, campaign, etc.) in various authorial sources. The Russian equivalents of truth in the item post-truth are reliability (достоверность), accuracy (точность), credibility (доверие); in the media the phrase post-truth comes to mean ‘to abandon or neglect the principles of objectivity and reliability’. It has been shown that in the USA and UK socio-political field expert assessments and interpretations of the claim itself are contradictory and are often marked with skepticism. It is clear, however, that it cannot be taken literally and that in science and education discourse, with the exception of history, it manifests itself differently: in close relation to scientific rational truths or facts, but not to daily factual truths described by H. Arendt. Also, specific sets of key words are used to describe manifestations of post-truth in the media and science. “Fake news” and election campaigns don’t seem to be the major features of the post-truther media. Instead, the concepts bullshit by H. Frankfurt and post-truth game by S. Fuller are competing for this role; however, they can’t be regarded as elaborated formal rhetorical schema either. Yu.Shatin alone made a pertinent and significant attempt to describe the new post-truther rhetoric. The specialist literature review shows that the media post-truth discourse is actually a manifestation of a deep crisis in the ‘canonical’ democracy, a reflection of its agonal state in the American-British vocabulary and narratives. The paper emphasizes that this kind of discourse has not only a home dimension, but also a foreign policy one and, consequently, internal and external addressing. Its reception in Russia is distorted due to remoteness of observers, which does not allow them to see how fakes and the new post-truth vocabulary are actually interpreted by the agents in the process of intra- or intercultural confrontation.
Toponymic Area of the Erzya Bagana Village, Samara Region: Lexical- Semantic and Structural-Comparative Analysis
Authors: Belenov N. V.
Published: September 2023

The article presents a lexical and semantic analysis of the toponymy of the Erzya Bagana village in Shentalinsky district of the Samara region. The obtained results are compared with the materials of the author’s research in other villages of the Mordva of Shentalinsky district, in the Erzya settlements of the Samara Volga region, as well as with the data on the Erzya dialects of other territories of the settlement of the Mordva-Erzya. The Shentala ethnoterritorial group of Mordvins includes the Erzya population of the villages of Bagana, Staroe Surkino, Novoe Surkino, Vasilevka, Senkino. The toponymy of the Bagana village and its environs has not yet been subjected to a comprehensive study, at the same time, such work should be intensified, since modern demographic processes contribute to the rapid disappearance of microtoponymy of rural settlements. To carry out a lexical and semantic analysis of the Bagana toponymy in order to identify its characteristic features and, at the same time, common features with the Erzya toponymy of other territories. The research materials were collected in the Bagana village during the 2021 field season with the help of G.M. Kert’s questionnaire developed specifically for the Finno-Ugric languages. When working on the collected material, lexico-semantic and comparative types of analysis were used. As a result of the conducted research, 31 toponymic units and a cluster of geographical vocabulary of the Bagana dialect of the Erzya-Mordovian language were introduced into scientific circulation, the main characteristics of the toponymic space of Bagana were revealed, which allowed for its comparative analysis with other Erzya toponymic spaces. The toponymic space under study reflects both the peculiarities of the Bagana dialect and the features of nomination and semantics of geographical names characteristic of the Shentala Mordva. In general, this toponymic space reveals common features with the toponymy that we find in villages with a significant proportion of the Erzya population in the Samara Volga region at the present stage: most names come from the Erzya and Russian languages, hybrid Erzya-Russian and Russian-Erzya names are also found in the toponymy, the main markers of the Erzya toponymic area are: the dual urban system of Alo pe – Vere pe, the formula of toponyms typical of Mordvins is “definable + appellative”.
Horse Harness Naming in Yakut (as compared to Mongolic languages)
Authors: Diachkovskiy F. N. , Popova N. I. , Trofimova S. M.
Published: September 2023

The paper analyzes and describes the lexico-semantic groups (further, LSG) “Horse harness” in Yakut in comparison to Khalkha-Mongolian, Buryat, and Kalmyk.

   The purpose of the study is to introduce horse harness naming in academic use in the comparative and comparative-historical aspects.

   Material from the Mongolic languages was used to compare and identify common terms and establish their Turkic and Mongolian stems. The material of the study was selected from the corresponding dictionaries; it also includes field records collected from informants during expeditions to Mongolia and Buryatia. The main methods are descriptive, comparative, comparative-historical, and that of continuous sampling. The analysis allowed us to determine the structure and semantics of the considered lexical units, to identify a significant number of similarities and differences in Yakut and Mongolic languages. The Yakut, Khalkha-Mongolian, Buryat and Kalmyk material showed both Turkic-Mongolic and Turkic layers common for the analyzed languages. At the same time, for Yakut the Russian layer was revealed. The analyzed material allows us to speak about the features of the Yakut language that distinguish it from other Turkic languages, and Buryat from all Mongolic languages, as well as about what brings the Yakut language closer to Buryat. Out of the 38 lexical units of the LSG «Horse Harness» in modern Yakut, the comparative analysis has revealed 9 units representing Mongolian parallels, most of which presumably penetrated from the Old Mongolian language in the pre-literate period. Interestingly, the phonetic structure of some of them makes it possible to attribute them to the earliest Yakut-Mongolian contacts.
Sociolinguistic and Philosophical Discursive Aspects of B. Shaw’s Play ‘Pygmalion’
Authors: Alexeyev A. B.
Published: September 2023

The article dwells on linguo-social aspects of the early 20th century discourse, primarily as they are shown in B. Shaw’s play ‘Pygmalion’, written in 1912 and steeped in the atmosphere of the England of that time. The definition of the term ‘discourse’ is given in accordance with M. Foucault’s theory. It is pointed out that any discourse is inextricably linked with historical factors of its origination as well as the ideology and – in a broader sense – the worldview of people living in a concrete historical epoch. General scientific methods of observation, interpretation and induction have been used. Linguistic methods including linguo-pragmatic and linguo-stylistic approaches to discourse have also been applied. The method of critical discourse analysis makes it possible to emphasize the importance and dynamism of discursive linguo-social aspects. It has been found that the plot of the play is mainly built by the heroes’ exchange on a number of trivial problems. On the other hand, it has philosophical and in particular linguo-philosophical issues that make up the core of the book. As a result, the author sheds some light on his contemporaries’ attitude to language (languages) as well as to certain social groups distinguished – among other criteria – from the point of view of their members’ fluency in received/standard English. The hybrid character of B. Shaw’s literary discourse is highlighted. It has been shown that, within the analyzed discourse framework, everyday and mundane philosophical discursive practices play a prominent role. The latter can be conducive to the spread of (linguo-social) prejudices but at the same time it is not uncommon for them to serve as a basis for an alternative discourse.
Psycholinguistic Issues of Medical Communication
Authors: Kameneva V. A. , Morozova I. S.
Published: September 2023

The present paper summarizes the available theoretical and empirical data of medical communication scientific research in the addresser-addressee aspect in Russian and foreign works. The information on the study of the psycholinguistic aspect of communication between the medical staff and the patient is systematized not only taking into account differences in the provision of medical services in Russia and abroad, but also depending on the age of communicants, the chosen communication strategies and the conditions of speakers’ effective interaction. The paper shows the scarcity of works dealing with the study of communication between a doctor and a child. The paper also considers some psychological aspects of child/adolescent communication with an adult, which is very important in doctors’ professional activity. It is pointed out that research on communication between a doctor and a parent/a legal representative of a minor patient is relevant, but also scarce. Foreign research is centered on communication of nurses and the patients/their relatives, as well as of patients with loss of voice. Russian scientists’ works, carried out on the basis of the communication analysis between the adult patient and the doctor, can be roughly divided into three types: 1) studies dealing with the strategies of the communicants. These are both communication strategies, conditioned by professional tasks of a doctor, and speech strategies implementing them; 2) works studying verbal, non-verbal and paraverbal means of communication between a doctor and a patient; 3) research describing and comparing effective communication conditions between a doctor and a patient. This study is grounded on the theoretical and methodological basis of psycholinguistics and takes into account the stipulations of communication theory. The methods of analysis, synthesis and systematization have been used to achieve the goal. The analysis and grouping of data confirmed the presence of theoretical and methodological flaws in the study of professional communication between a doctor and other participants of medical communication. The works revealed an unintentional blending of the concepts “professional communicative strategy” and “speech strategy”. The analysis of linguistic means that implement speech strategy tactics in medical communication is important for linguistic research in the future.
Uso de la ketamina endovenosa en anestesiología: revisión de la evidencia y mejores prácticas
Authors: Matos Riquene Héctor Marcial , Martínez Milka García
Published: September 2023

La ketamina endovenosa es un anestésico disociativo utilizado en anestesiología y analgesia. Aunque es eficaz, puede causar efectos secundarios psicomiméticos. Se han realizado numerosos estudios sobre su dosificación, seguridad y eficacia, pero se necesitan más investigaciones para determinar su lugar en la práctica clínica y evaluar su eficacia y seguridad en diferentes poblaciones, objetivo fundamental que persigue esta revisión, luego de realizar una búsqueda bibliográfica en las bases de datos Medline, PubMed y Cochrane. Observando que existe variabilidad en los protocolos de administración, lo que dificulta la interpretación de los resultados, se han encontrado dosis efectivas para la anestesia general y la analgesia en el manejo del dolor. Además, el fármaco ha mostrado efectos antidepresivos. Aunque se considera segura, se han reportado efectos secundarios leves y se sugiere precaución con el uso prolongado. Se necesita una cuidadosa evaluación de los pacientes y protocolos estandarizados para garantizar una administración segura y efectiva de la ketamina.
Enfoque anestésico en pacientes con mucopolisacaridosis
Authors: Muñoz Pérez Xiomara , Feris Monterrosa Nazhid
Published: September 2023

Las Mucopolisacaridosis (MPS) son un grupo de patologías raras que consisten en deficiencias enzimáticas y se caracterizan por la acumulación lisosomal de glucosaminoglucanos (GAG). La mayoría de pacientes con MPS durante el curso de su enfermedad requerirán anestesia para procedimientos diagnósticos o cirugías. El objetivo del presente artículo es revisar el estado actual del conocimiento en torno al manejo anestésico en pacientes con MPS. Revisión no sistemática. Se realizó una búsqueda literaria en Pubmed, Lilacs, Google Scholar y se escogieron los artículos relevantes. El conocimiento de la clasificación, fisiopatología, tratamiento, la adecuada valoración preoperatoria permiten anticiparse a los riesgos y complicaciones que representan estas patologías, especialmente los retos en el manejo de la vía aérea, el déficit cognitivo, la disfunción cardiopulmonar y los riesgos de daño medular permanente.
Anafilaxia por dipirona en gestante con analgesia epidural de parto
Authors: Quispe Pilco Eddisson , Quispe Pilco Jhoscy , Calderón Lozano Marjorie , León Castillo Jessica , Solsol Figueroa Jorge , Cavalcanti Castillo Magaly
Published: September 2023

La anafilaxia es una grave reacción sistémica de hipersensibilidad de inicio súbito e impredecible, presenta un cuadro clínico que compromete gravemente los sistemas cutáneo, respiratorio y cardiovascular. En gestantes el diagnóstico y tratamiento pueden ser difíciles por los cambios fisiológicos del embarazo y el riesgo del bienestar fetal. Se reporta el caso de una gestante en trabajo de parto que presenta anafilaxia luego de la administración de dipirona y analgesia epidural de parto. Se evidenció buena respuesta al tratamiento con adrenalina, con adecuada recuperación luego del evento. La paciente no tenía antecedentes de hipersensibilidad a la dipirona u otros fármacos, para identificar el agente causal se realizó una prueba de activación de basófilos a la dipirona resultando negativa y posteriormente se realizaron pruebas cutáneas: Prick Test y prueba intradérmica con todos los fármacos sospechosos dando ambas pruebas positivas a dipirona.
Selective and Biocompatible Detection of Acetylcholine with a Fluorous Potentiometric Laser-Induced Graphene Sensor
Authors: Amirghasemi Farbod , Al-Shami Abdulrahman , Ushijima Kara , Mousavi Maral P. S.
Published: September 2023

Acetylcholine (ACh) appears in the brain and body of mammalians and functions both as a neuromuscular transmitter and neuromodulator. Tools with high spatial and temporal resolution to study ACh are in high demand due to the diverse function of ACh and its implications in neurodegenerative diseases. This work presents a highly promising sensor for a selective and biocompatible recording of ACh with a fluorous-phase potentiometric sensor. Fluorous compounds are nonpolar and not miscible with water and hydrocarbons, making them bio-orthogonal and biocompatible. This work presents the first proof-of-concept detection of ACh using a fluorous sensing phase. We show drastic improvement in selectivity for the fluorous phase ion-exchanger electrode compared to a conventional ion-exchanger potentiometric sensor with a lipophilic sensing membrane. As a result, we observed more than an order of magnitude improvement in the limit of detection, and two orders of magnitude increase in the electrode linear range during measurement of ACh in artificial cerebrospinal fluid. To enable the development of flexible and compact ACh sensing neural probes, this work combines the unique advantages of the fluorous phase with a flexible laser-induced porous graphitic carbon (LIG) to create the first flexible solid-contact fluorous-phase potentiometric sensor. The fluorous-phase solid-contact LIG ion exchanger electrode showed a near Nernstian slope of 54.9 ±0.8 and a 42 nM limit of detection.
Simplified Preservation of Equal Paths Spectroscopy
Authors: Nimerovsky Evgeny , Varkey Abel Cherian , Kim Myeongkyu , Becker Stefan , Andreas Loren B.
Published: September 2023

Inspired by the recently proposed Transverse mixing Optimal control Pulses (TROP) approach for improving signal in multi-dimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equal paths spectroscopy (SPEPS). It transfers both transverse components of magnetization that occur during indirect evolutions, theoretically enabling a √2 improvement in sensitivity for each such dimension. We compare SPEPS transfer with TROP and cross polarization (CP) using membrane protein and fibril samples at MAS of 55 kHz and 100 kHz. In 3D (H)CANH spectra, SPEPS outperformed TROP and CP by factors of, on average, 1.16 and 1.69, respectively for the membrane protein, but only marginal improvement of 1.09 was observed for the fibril. These differences are discussed making note of the longer transfer time used for CP, 14 ms, as compared with 2.9 and 3.6 ms for SPEPS and TROP, respectively. Using SPEPS for two transfers in the 3D (H)CANCO experiment resulted in even larger benefit in signal intensity, with an average improvement of 1.82 as compared with CP. This results in a multifold time savings, in particular considering the weaker peaks that are observed to benefit the most from SPEPS.
Room Temperature Electroreductive Carboxylation of Unactivated Alkyl Chlorides with CO2 Using a Ni(II) NNN-Pincer Complex. Towards Polyvinyl chloride (PVC) Upgrading
Authors: Sarkar Prasenjit , Dash Sandeep , Krause Jeanette , Panetier Julien , Jiang Jianbing
Published: September 2023

In organic synthesis, direct carboxylation of organohalides with carbon dioxide is a highly desirable transformation because it uses feedstock chemicals and produces carboxylic acids, which are among the most widely used classes of organic compounds. Alkyl carboxylic acids are favored motifs in many medicines and physiologically active substances. Carbon dioxide (CO2) is an ideal C1 source for organic synthesis because of its high abundance, low cost, nontoxicity, and recyclability. This article describes a nickel-catalyzed electrochemical method for producing alkyl carboxylic acids via carboxylation of unactivated alkyl chlorides with CO2. The development of a Ni pincer complex (complex 1) with a redox-active ligand as an electrocatalyst to convert unactivated alkyl chlorides to the corresponding acids over less desirable homocoupling products is presented. Electronic structure calculations revealed that CO2 binding occurs in a resting state to yield an 2-CO2 adduct and that the C-Cl bond activation step is the TOF-determining transition state, which has an activation energy of 19.3 kcal/mol. A combination of electroanalytical methods, control experiments, and computational studies revealed the mechanism of the electrocarboxylation reaction. In addition, complex 1 has been demonstrated as an efficient catalyst to upgrade polyvinyl chloride to polyacrylate in 95% yield.
The CatMath: An Online Predictive Platform for Thermal + Electrocatalysis
Authors: Liu Heng , Zheng Hao , Jia Zhenhe , Zhou Binghui , Liu Yan , Chen Xuelu , Feng Yajun , Wei Li , Yang Weijie , Li Hao
Published: September 2023

The catalytic volcano activity models are the quantified and visualized tools of the Sabatier principle for heterogeneous catalysis, which can depict the intrinsic activity optima and trends of a catalytic reaction as a function of the reaction descriptors, i.e., the bonding strengths of key reaction species. These models can be derived by microkinetic modeling and/or free energy changes in combination with the scaling relations among the reaction intermediates. Herein, we introduce the CatMath - an online platform for generating a variety of common and industrially important thermal + electrocatalysis. With the CatMath, users can request the volcano models for available reactions and analyze their materials of interests as potential catalysts. Besides, the CatMath provides the function of the online generation of surface Pourbaix diagram for surface state analysis under electrocatalytic conditions, which is an essential step before analyzing the activity of an electrocatalytic surface. All the model generation and analysis processes are realized by cloud computing via a user-friendly interface.
A targeted sequencing extension for transcript genotyping in single-cell transcriptomics
Authors: Van Horebeek Lies , David Margaux , Dedoncker Nina , Mallants Klara , Bijnens Baukje , Goris An , Dubois Bénédicte
Published: September 2023

As no existing methods within the single-cell RNA sequencing repertoire combine genotyping of specific genomic loci with high throughput, we evaluated a straightforward, targeted sequencing approach as an extension to high-throughput droplet-based single-cell RNA sequencing. Overlaying standard gene expression data with transcript level genotype information provides a strategy to study the impact of genetic variants. Here, we describe this targeted sequencing extension, explain how to process the data and evaluate how technical parameters such as amount of input cDNA, number of amplification rounds, and sequencing depth influence the number of transcripts detected. Finally, we demonstrate how targeted sequencing can be used in two contexts: (1) simultaneous investigation of the presence of a somatic variant and its potential impact on the transcriptome of affected cells and (2) evaluation of allele-specific expression of a germline variant in ad hoc cell subsets. Through these and other comparable applications, our targeted sequencing extension has the potential to improve our understanding of functional effects caused by genetic variation.
Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression
Authors: Gorospe Choco Michael , Carvalho Gustavo , Herrera Curbelo Alicia , Marchhart Lisa , Mendes Isabela C , Niedźwiecka Katarzyna , Wanrooij Paulina H
Published: September 2023

Mitochondria are central to numerous metabolic pathways whereby mitochondrial dysfunction has a profound impact and can manifest in disease. The consequences of mitochondrial dysfunction can be ameliorated by adaptive responses that rely on crosstalk from the mitochondria to the rest of the cell. Such mito-cellular signalling slows cell cycle progression in mitochondrial DNA–deficient (ρ0)Saccharomyces cerevisiaecells, but the initial trigger of the response has not been thoroughly studied. Here, we show that decreased mitochondrial membrane potential (ΔΨm) acts as the initial signal of mitochondrial stress that delays G1-to-S phase transition in both ρ0and control cells containing mtDNA. Accordingly, experimentally increasing ΔΨm was sufficient to restore timely cell cycle progression in ρ0cells. In contrast, cellular levels of oxidative stress did not correlate with the G1-to-S delay. Restored G1-to-S transition in ρ0cells with a recovered ΔΨm is likely attributable to larger cell size, whereas the timing of G1/S transcription remained delayed. The identification of ΔΨm as a regulator of cell cycle progression may have implications for disease states involving mitochondrial dysfunction.
Predictors of Prediabetes and Undiagnosed Diabetes Mellitus Based on HbA1c Levels in Indonesia
Authors: Kusuma Irma Surya , Syarif Syahrizal
Published: September 2023

Prediabetes and Undiagnosed Diabetes Mellitus (UDDM) are associated with an increased risk of diabetes complications and other cardiovascular diseases. Early detection of both health problems is expected to reduce the burden of non-communicable diseases in the future. The purpose of this study is to investigate predictors of prediabetes and UDDM based on HbA1c levels among population ≥ 15 years old in Indonesia. This cross-sectional study involved 6,065 respondents of Indonesian Family Life Survey 5 (IFLS 5) who met the inclusion and exclusion criteria. Data associated with sociodemographic characteristics, lifestyle risk factors, hypertension, and obesity were obtained. Prediabetes was defined as HbA1c between 5.7-6.4%, while diabetes was defined as HbA1c ≥ 6.5%. Multinomial logistic regression analysis was performed to estimate adjusted Odds Ratio (aOR). The results showed that predictors of prediabetes were age, gender, marital status, and obesity, while predictors of UDDM were age, hypertension, and obesity. Identification of risk factors and early detection of prediabetes and UDDM is important, so that appropriate intervention can be given immediately to prevent complications.
Layering History: Applying the Historic Urban Landscape Approach to the New Zealand Context
Authors:   , Gorton Adelaide
Published: September 2023

The housing crisis is a significant contemporary issue in New Zealand that is particularly contentious in areas of significant heritage value. While current heritage management systems in New Zealand present development as a threat to heritage, recent advancements in heritage management theory present an alternative perspective. The Historic Urban Landscape (HUL) approach is a theoretical and methodological framework that presents the urban landscape as a result of the layering of events and meanings imprinted on the environment over time, which collectively result in the environment experienced today. As such, heritage is considered an integral part of the urban landscape, and instrumental in guiding urban development towards a sustainable future, as opposed to being a barrier to it. This thesis presents the HUL approach as a viable solution to address the housing crisis in New Zealand.

This research tests the effects of the Historic Urban Landscape approach on the housing and social needs of an urban community, by implementing an adaptation of the framework’s recommended methodology within the inner-city suburb of Mount Cook, Wellington. As the HUL approach is primarily used by local governments as a long-term strategising tool, this thesis develops a master plan, subsequent Character guides and finally a conceptual architectural intervention on a key site in the suburb, to exemplify how HUL could be implemented within a New Zealand context, and what the effects of this might be in the urban environment. The research found that the implementation of the Historic Urban Landscape approach is a viable option for meeting the housing and social needs of urban communities throughout New Zealand. It guides the development of housing and other amenities within the historic urban landscape in a way that is simultaneously sympathetic to the site and addresses the needs of the community, in a way that comprehensively and sensitively responds to the unique contexts of the historic urban landscape in question.
“I Love Who I Am as a Nonbinary Person—That’s When I’m Most at Home”: Life-Stories of Nonbinary Adults and Elders from Aotearoa New Zealand Spanning 1953 to 2023
Authors:   , Ramsay Erin
Published: September 2023

This thesis explores oral history life-stories, as well as life-stories gathered as written qualitative data, of nonbinary adults and elders from Aotearoa New Zealand. Nonbinary gender, which encompasses gender identities outside the binary of man/woman, has garnered global attention in recent years thanks in part to the emergence of certain Western identity labels (including ‘nonbinary’ itself). However, this kind of gender has an older history. The study opens with a consideration of what might be included within the umbrella of nonbinary history in New Zealand, including an overview of gender diversity from pre-colonial gender diverse takatāpui to present figures, concluding that an oral history methodology is best suited to researching nonbinary history in Aotearoa. Three subsequent chapters on the different life-stages of the research participants—childhood, younger adulthood and older adulthood—outline what nonbinary life has looked like for them from the middle of the twentieth century to the present day. The first chapter highlights how in childhood, participants (narrators) encountered both the violence of gender hegemony and greater space for gender nonconformity than might be expected in settings like rural New Zealand and the postwar period. The second chapter follows the narrators’ first interactions with lesbian, gay, bisexual and takatāpui communities and shows how these could be safe spaces for expression but how they could also be limited in their acceptance of ‘non-normative’ gender and sexuality. The third chapter investigates the narrators’ engagement with trans and nonbinary models of identity from around the turn of the century onward, as well as what challenges they currently face and what community looks like for them today. This thesis contributes to a growing body of research on trans history in Aotearoa. It shows that nonbinary people have a past here beyond the twenty-first century, and that despite gender dogma, they have lived full and rewarding lives.
Ucing Corona: Modifikasi Permainan Tradisional pada Era Adaptasi Kebiasaan Baru
Authors: Harini Yostiani Noor Asmi , Zenab Ai Siti
Published: September 2023

Pada era pandemi covid, permainan Ucing-ucingan tidak lagi dimainkan padahal permainan tersebut memiliki fungsi penting bagi perkembangan motorik, kognitif, bahasa, dan afektif anak. Tujuan artikel ini menawarkan permainan Ucing Corona yang merupakan modifikasi dari permainan Ucing-ucingan yang cocok dimainkan pada era adaptasi kebiasaan baru. Ucing Corona dikembangkan melalui perspektif ilmu folklor dan transformasi. Ucing Corona diciptakan melalui tahapan identifikasi pola permainan, identifikasi irisan permainan, dan transformasi permainan yang disesuaikan dengan kebutuhan adaptasi kebiasaan baru. Hasil penelitian ini menghasilkan struktur permainan Ucing Corona dan fungsinya. Hasil penelitian ini diharapkan dapat memberikan alternatif permainan yang sesuai dengan kebutuhan adaptasi kebiasaan baru.Kata kunci: adaptasi kebiasaan baru, folklor, modifikasi, Ucing Corona.
gamificación en el aprendizaje de Segundas Lenguas Extranjeras. FLE y su aprendizaje en la Enseñanza Pública de España
Authors: Santos González Denis
Published: September 2023

En el sistema educativo español uno de los objetivos claves curriculares es el aprendizaje de lenguas extranjeras. Por ello, se deben revisar los procedimientos, concretamente las metodologías, que se utilizan para mejorar la eficiencia y calidad de su enseñanza. Dentro del aprendizaje de segundas lenguas extranjeras, el francés tiene una importancia fundamental, debido a la cercanía geográfica a España y a la importancia del idioma.

Su sistema de enseñanza debe ser foco de continua renovación por lo que se deben investigar diferentes metodologías, herramientas y recursos para su enseñanza. Es una época de revolución digital, en la que el uso de nuevas tecnologías está a la orden del día. La gamificación es una metodología que se ha viene utilizando desde años, si bien, en la última década ha cobrado un nuevo sentido debido a su relación con las nuevas tecnologías. Se trata de enseñar jugando lo que produce una alta motivación para el alumnado.

La aplicación de esta metodología a la enseñanza de la segunda lengua extranjera, en este caso, francés, no se trata de un campo que haya sido ampliamente investigado; sin embargo, en este artículo se va a realizar una revisión bibliográfica acerca de las ventajas de esta metodología para este ámbito educativo, así como los resultados educativos que se han obtenido en diferentes programas en donde se ha utilizado.
Le développement des compétences plurilingue et linguistique à la lumière de la LOMLOE
Authors: Nuñez Nadine
Published: September 2023

Notre proposition didactique interdisciplinaire, relève de la relation entre plusieurs disciplines. Nous aborderons une approche du plurilinguisme s´inscrivant dans une perspective communicative et interculturelle. Le site TV5 monde, souvent utilisé para les professeurs de français pour réviser certains contenus en classe, va nous offrir l´opportunité de découvrir la langue française tout en approfondissant aussi les connaissances linguistiques et culturelles de notre langue maternelle, dans ce cas concret, l´espagnol. Ceci sera envisageable dans une classe de 3ºESO, dans les matières de Français et Langue espagnole et dont les objectifs spécifiques seront traités de manière parallèle et les registres de langue sont l´un des exemples que nous allons travailler.
Diseño de un recurso TIC como refuerzo del Francés Lengua Extranjera para alumnado con dificultades de aprendizaje
Authors: Baquedano Morales Teresa , Castrillo de Larreta Azelain Mª Dolores
Published: September 2023

El presente trabajo es un estudio preliminar cuyo principal objetivo es el diseño de un recurso tecnológico creado especialmente para alumnado con dificultades de aprendizaje que está adquiriendo el francés como lengua extranjera, mediante un modelo de trabajo con un enfoque multimodal. El estudio se contextualiza en un colegio bilingüe español-francés de Educación Primaria en Aragón que es, asimismo, centro de atención preferente para el trastorno del espectro autista. Tras la intervención se concluye que la combinación de texto, pictogramas y realidad aumentada podría contribuir a la mejora de algunos aspectos de lectoescritura de la lengua extranjera en alumnado con dificultades o necesidades educativas, sirviendo igualmente de refuerzo en este proceso para el resto del alumnado.