bluuebunny/crossref_metadata_2025 huggingface dataset:
Indication and short term outcome of Mechanical Ventilation in Neonates in a tertiary care hospital
Authors: Jahan Nasim , Haque Zabrul SM , Mannan Md Abdul , Nasrin Mahmuda , Afroz Farhana , Parvez Anwar , Rahman Taifur , Islam Manjurul
Published: January 2017

Background: Mechanical ventilation of newborn has been practiced for several years with advances in many ways. As compared to the western world, neonatal ventilation in our country started in recent years.Subjects, Methods and Results: A retrospective chart review was conducted to analyze the common indications and outcome of neonates requiring mechanical ventilation in neonatal intensive care unit at Ad-Din Medical College Hospital from January 2012 to July 2013. Fifty eight neonates were ventilated over a period of 19 months of whom 39 (67.24%) survived. Respiratory distress syndrome was the commonest indication for ventilation (32.75%), followed by Perinatal asphyxia (18.96%), Pneumonia (13.79%), Neonatal Sepsis (13.79%), Meconium aspiration syndrome 6(10.16%) & Pneumothorax 6 (10.16%). Among the babies who survived, 35(89.74%) were managed solely with conventional ventilator and 4 babies required both conventional and High Frequency Oscillatory (HFOV) ventilation. Survival rate was higher where birth weight >2500gm (76.19%) and gestational age 34-37 weeks (88.88%). Survival rates was (69.23%) in <30 weeks and 60% in <1000 g. Prolong ventilator support was needed for Respiratory Distress Syndrome without surfactant (mean 254 hrs), Perinatal asphyxia (mean 187hrs) and Neonatal sepsis (mean 187hrs). Common complications were Pneumonia (12.06%), Pneumothorax (10.34%), sepsis (8.6%) & Pulmonary hemorrhage (3.4%). Survival rate was higher in babies requiring mechanical ventilation for respiratory distress syndrome (84.21%).Conclusion: Use of surfactant could decrease the duration of ventilation and mortality further in babies with respiratory distress syndrome.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.24-28
Prompt Response to single injection of Bevacizumab in a case of Fibrinous Central Serous Choroidopathy (CSC).
Authors: Khan Balbir , Kaur Rajwinder , Anand Vartika , Matreja Prithpal S
Published: January 2017

Purpose: Central Serous Choroidopathy (CSC) is a disease of young and middle aged adults as a localized detachment of the neurosensory retina. Though the cause of CSC remains unknown, it is believed that abnormalities in choroidal circulation make overlying retinal pigment epithelium dysfunctional, resulting in development of a serous retinal detachment. Subretinal fibrin accumulation is rare but vision threatening association of CSC.Methods: A young 31 years female with acute central serous chorioretinopathy received an Intravitreal bevacizumab (1.25 mg/0.05 ml) injection. At baseline and follow-up visits, patients had best corrected visual acuity (BCVA), IOP assessment, dilated fundus examination, fundus photography, fluorescein angiography (FA), and Optical Coherence Topography(OCT) imaging.Results: Patient showed resolution of fibrin, resolution of intraretinal or subretinal fluid promptly, and improvement in visual symptoms and acuity within 1 month. At 6 months patient is maintaining 20/20 vision without any recurrence.Conclusions: Intravitreal bevacizumab injection for acute fibrinous central serous choroidopathy may result in prompt resolution of neurosensory detachment and reduction of angiographic leakage. These short-term results suggest that Intravitreal bevacizumab injection may constitute a promising therapeutic option in fibrinous central serous chorioretinopathy.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.157-160
Kernel Clustering with a Differential Harmony Search Algorithm for Scheme Classification
Authors: Feng Yu , Zhou Jianzhong , Tayyab Muhammad
Published: January 2017

This paper presents a kernel fuzzy clustering with a novel differential harmony search algorithm to coordinate with the diversion scheduling scheme classification. First, we employed a self-adaptive solution generation strategy and differential evolution-based population update strategy to improve the classical harmony search. Second, we applied the differential harmony search algorithm to the kernel fuzzy clustering to help the clustering method obtain better solutions. Finally, the combination of the kernel fuzzy clustering and the differential harmony search is applied for water diversion scheduling in East Lake. A comparison of the proposed method with other methods has been carried out. The results show that the kernel clustering with the differential harmony search algorithm has good performance to cooperate with the water diversion scheduling problems.
A Temperature Sensor Clustering Method for Thermal Error Modeling of Heavy Milling Machine Tools
Authors: Li Fengchun , Li Tiemin , Wang Haitong , Jiang Yao
Published: January 2017

A clustering method is an effective way to select the proper temperature sensor location for thermal error modeling of machine tools. In this paper, a new temperature sensor clustering method is proposed. By analyzing the characteristics of the temperature of the sensors in a heavy floor-type milling machine tool, an indicator involving both the Euclidean distance and the correlation coefficient was proposed to reflect the differences between temperature sensors, and the indicator was expressed by a distance matrix to be used for hierarchical clustering. Then, the weight coefficient in the distance matrix and the number of the clusters (groups) were optimized by a genetic algorithm (GA), and the fitness function of the GA was also rebuilt by establishing the thermal error model at one rotation speed, then deriving its accuracy at two different rotation speeds with a temperature disturbance. Thus, the parameters for clustering, as well as the final selection of the temperature sensors, were derived. Finally, the method proposed in this paper was verified on a machine tool. According to the selected temperature sensors, a thermal error model of the machine tool was established and used to predict the thermal error. The results indicate that the selected temperature sensors can accurately predict thermal error at different rotation speeds, and the proposed temperature sensor clustering method for sensor selection is expected to be used for the thermal error modeling for other machine tools.
High Energy-Efficient Windows with Silica Aerogel for Building Refurbishment: Experimental Characterization and Preliminary Simulations in Different Climate Conditions
Authors: Buratti Cinzia , Moretti Elisa , Zinzi Michele
Published: January 2017

The paper deals with the potential of high energy-efficient windows with granular silica aerogel for energy saving in building refurbishment. Different glazing systems were investigated considering two kinds of granular silica aerogel and different glass layers. Thermal transmittance and optical properties of the samples were measured and used in building simulations. The aerogel impact on heat transfer is remarkable, allowing a thermal transmittance of 1.0–1.1 W/(m2·K) with granular aerogel in interspace only 15 mm in thickness. A 63% reduction in U-value was achieved when compared to the corresponding conventional windows, together with a significant reduction (30%) in light transmittance. When assembled with a low-e glass, the U-value reduction was lower (31%), but a moderate reduction in light transmittance (about 10%) was observed for larger granules. Energy simulations for a case study in different climate conditions (hot, moderate, and cold) showed a reduction in energy demand both for heating and cooling for silica aerogel glazing systems, when compared to the conventional ones. The new glazings are a suitable solution for building refurbishment, thanks to low U-values and total solar transmittance, also in warm climate conditions.
Carbon Nanostructures for Tagging in Electrochemical Biosensing: A Review
Authors: Yáñez-Sedeño Paloma , Campuzano Susana , Pingarrón José
Published: January 2017

Growing demand for developing ultrasensitive electrochemical bioassays has led to the design of numerous signal amplification strategies. In this context, carbon-based nanomaterials have been demonstrated to be excellent tags for greatly amplifying the transduction of recognition events and simplifying the protocols used in electrochemical biosensing. This relevant role is due to the carbon-nanomaterials’ large surface area, excellent biological compatibility and ease functionalization and, in some cases, intrinsic electrochemistry. These carbon-based nanomaterials involve well-known carbon nanotubes (CNTs) and graphene as well as the more recent use of other carbon nanoforms. This paper briefly discusses the advantages of using carbon nanostructures and their hybrid nanocomposites for amplification through tagging in electrochemical biosensing platforms and provides an updated overview of some selected examples making use of labels involving carbon nanomaterials, acting both as carriers for signal elements and as electrochemical tracers, applied to the electrochemical biosensing of relevant (bio)markers.
Chitosan–Collagen Coated Magnetic Nanoparticles for Lipase Immobilization—New Type of “Enzyme Friendly” Polymer Shell Crosslinking with Squaric Acid
Authors: Ziegler-Borowska Marta , Chelminiak-Dudkiewicz Dorota , Siódmiak Tomasz , Sikora Adam , Wegrzynowska-Drzymalska Katarzyna , Skopinska-Wisniewska Joanna , Kaczmarek Halina , Marszałł Michał
Published: January 2017

This article presents a novel route for crosslinking a polysaccharide and polysaccharide/protein shell coated on magnetic nanoparticles (MNPs) surface via condensation reaction with squaric acid (SqA). The syntheses of four new types of collagen-, chitosan-, and chitosan–collagen coated magnetic nanoparticles as supports for enzyme immobilization have been done. Structure and morphology of prepared new materials were characterized by attenuated total reflectance Fourier-transform infrared (ATR-FTIR), XRD, and TEM analysis. Next, the immobilization of lipase from Candida rugosa was performed on the nanoparticles surface via N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC)/N-hydroxy-succinimide (NHS) mechanism. The best results of lipase activity recovery and specific activities were observed for nanoparticles with polymer shell crosslinked via a novel procedure with squaric acid. The specific activity for lipase immobilized on materials crosslinked with SqA (52 U/mg lipase) was about 2-fold higher than for enzyme immobilized on MNPs with glutaraldehyde addition (26 U/mg lipase). Moreover, a little hyperactivation of lipase immobilized on nanoparticles with SqA was observed (104% and 112%).
Barriers to Energy Efficiency in Swedish Non-Energy-Intensive Micro- and Small-Sized Enterprises—A Case Study of a Local Energy Program
Authors: Backman Fredrik
Published: January 2017

Improved energy efficiency has become a strategic issue and represents a priority for European competitiveness. Countries adopt various energy policies on local and national levels where energy audit programs are the most common energy end-use efficiency policy for industrial small- and medium-sized enterprises (SMEs). However, studies indicate that cost-efficient energy conservation measures are not always implemented, which can be explained by the existence of barriers to energy efficiency. This paper investigates how Swedish municipalities can support local micro- and small-sized enterprises with improved energy efficiency and the existence of different barriers to the implementation of energy efficiency. Relating this empirical case study to the theoretical barriers outlined in the text, this study found that the major explanatory factors related to non-implementation of cost-effective energy efficiency measures among micro- and small-sized industrial enterprises were bounded rationality (lack of time and/or other priorities), split incentives (having other priorities for capital investments), and imperfect information (slim organization and lack of technical skill). This study also found that information in the form of a report was the main thing that companies gained from working on the project “Energy-Driven Business”. Notably, the study involved companies that had participated in a local energy program and, still, companies face major barriers inhibiting implementation, indicating a need to further study other alternative policy models and how knowledge transfer can be improved.
Association of School Environment and After-School Physical Activity with Health-Related Physical Fitness among Junior High School Students in Taiwan
Authors: Lo Kai-Yang , Wu Min-Chen , Tung Shu-Chin , Hsieh City , Yao Hsueh-Hua , Ho Chien-Chang
Published: January 2017

The relationship between students’ school environment and exercise habits is complex, and is affected by numerous factors. However, the few studies that have been conducted on this relationship have reported inconsistent results, especially regarding Taiwanese students. We conducted this cross-sectional study to investigate the association of school environment and after-school physical activity with health-related physical fitness in Taiwanese adolescents. Data were drawn from a national survey conducted by the Ministry of Education in Taiwan in 2008 of health-related physical fitness measurements among junior high school students (649,442 total) in grades seven to nine.School environment (level of urbanization, school size, presence of sports field or gymnasium) and after-school physical activity were assessed for their association with adolescents’ physical fitness measurements (body mass index (BMI), bent-leg sit-ups, 800-/1600-m run, sit-and-reach, standing long jump). Urban boys and girls perform significantly better in muscle strength and endurance, cardiorespiratory endurance, flexibility, and explosive power; girls from rural areas exhibited significantly worse scores in body composition. Boys from large-size schools performed the worst in cardiorespiratory endurance, flexibility, and explosive power; whereas girls from large-size schools performed the worst in muscle strength, muscle endurance, and explosive power, but had the best score for body composition. However, the differences in body composition of boys from large-, medium-, and small- size schools did not reach a statistically significant level. Adolescents of both genders in schools with a sports field or gymnasium exhibited significantly better in muscle strength and endurance, cardiorespiratory endurance, and explosive power. Boys in schools with a sports field or gymnasium had significantly better body composition; girls in schools with sports field or gymnasium differed significantly in flexibility. Adolescents of both genders who participated in physical activity after school had significantly better body composition, cardiorespiratory endurance, and flexibility. Boys who participated in physical activity after school significantly differed in explosive power, whereas girls who participated in physical activity after school exhibited significantly better flexibility. Thus, the current study demonstrated that some factors, including urbanization (school location in rural or urban areas), school size, school facility provision (school with or without sports fields or gymnasiums), and after-school physical activity participation are more important than others in shaping adolescents’ physical fitness in Taiwan; meanwhile, these association patterns differed by gender.
Antibacterial Activities and Possible Modes of Action of Acacia nilotica (L.) Del. against Multidrug-Resistant Escherichia coli and Salmonella
Authors: Sadiq Muhammad , Tarning Joel , Aye Cho Tay , Anal Anil
Published: January 2017

Medicinal plants are frequently used for the treatment of various infectious diseases. The objective of this study was to evaluate the antibacterial activity and mode of action of Acacia nilotica and the antibiogram patterns of foodborne and clinical strains of Escherichia coli and Salmonella. The mechanism of action of acacia extracts against E. coli and Salmonella was elucidated by observing morphological damages including cell integrity and cell membrane permeability, as well as changes in cell structures and growth patterns in kill-time experiments. The clinical isolates of E. coli and Salmonella were found resistant to more of the tested antibiotics, compared to food isolates. Minimum inhibitory concentration and minimum bactericidal concentration of acacia leaf extracts were in the ranges of 1.56–3.12 mg/mL and 3.12–6.25 mg/mL, respectively, whereas pods and bark extracts showed somewhat higher values of 3.12–6.25 mg/mL and 6.25–12.5 mg/mL, respectively, against all tested pathogens. The release of electrolytes and essential cellular constituents (proteins and nucleic acids) indicated that acacia extracts damaged the cellular membrane of the pathogens. These changes corresponded to simultaneous reduction in the growth of viable bacteria. This study indicates that A. nilotica can be a potential source of new antimicrobials, effective against antibiotic-resistant strains of pathogens.
Hair Growth Promoting and Anticancer Effects of p21-activated kinase 1 (PAK1) Inhibitors Isolated from Different Parts of Alpinia zerumbet
Authors: Taira Nozomi , Nguyen Binh , Tawata Shinkichi
Published: January 2017

PAK1 (p21-activated kinase 1) is an emerging target for the treatment of hair loss (alopecia) and cancer; therefore, the search for PAK1 blockers to treat these PAK1-dependent disorders has received much attention. In this study, we evaluated the anti-alopecia and anticancer effects of PAK1 inhibitors isolated from Alpinia zerumbet (alpinia) in cell culture. The bioactive compounds isolated from alpinia were found to markedly promote hair cell growth. Kaempferol-3-O-β-d-glucuronide (KOG) and labdadiene, two of the isolated compounds, increased the proliferation of human follicle dermal papilla cells by approximately 117%–180% and 132%–226%, respectively, at 10–100 μM. MTD (2,5-bis(1E,3E,5E)-6-methoxyhexa-1,3,5-trien-1-yl)-2,5-dihydrofuran) and TMOQ ((E)-2,2,3,3-tetramethyl-8-methylene-7-(oct-6-en-1-yl)octahydro-1H-quinolizine) showed growth-promoting activity around 164% and 139% at 10 μM, respectively. The hair cell proliferation induced by these compounds was significantly higher than that of minoxidil, a commercially available treatment for hair loss. Furthermore, the isolated compounds from alpinia exhibited anticancer activity against A549 lung cancer cells with IC50 in the range of 67–99 μM. Regarding the mechanism underlying their action, we hypothesized that the anti-alopecia and anticancer activities of these compounds could be attributed to the inhibition of the oncogenic/aging kinase PAK1.
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
Authors: Fasching Patrizia , Stradner Martin , Graninger Winfried , Dejaco Christian , Fessler Johannes
Published: January 2017

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases.
Development of a Topical Resveratrol Formulation for Commercial Applications Using Dendrimer Nanotechnology
Authors: Pentek Tyler , Newenhouse Eric , O’Brien Brennin , Chauhan Abhay
Published: January 2017

Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms. We have also developed a high performance liquid chromatography method to measure the resveratrol within the final product. PAMAM dendrimers increased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore, this product would be water based ‘green’ formulation devoid of harsh organic solvents and oils and can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to increase overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation was successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation in anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex could also be added to other product forms for additional purposes and applications.
Intrinsic Dynamics Analysis of a DNA Octahedron by Elastic Network Model
Authors: Hu Guang , He Lei , Iacovelli Federico , Falconi Mattia
Published: January 2017

DNA is a fundamental component of living systems where it plays a crucial role at both functional and structural level. The programmable properties of DNA make it an interesting building block for the construction of nanostructures. However, molecular mechanisms for the arrangement of these well-defined DNA assemblies are not fully understood. In this paper, the intrinsic dynamics of a DNA octahedron has been investigated by using two types of Elastic Network Models (ENMs). The application of ENMs to DNA nanocages include the analysis of the intrinsic flexibilities of DNA double-helices and hinge sites through the calculation of the square fluctuations, as well as the intrinsic collective dynamics in terms of cross-collective map calculation coupled with global motions analysis. The dynamics profiles derived from ENMs have then been evaluated and compared with previous classical molecular dynamics simulation trajectories. The results presented here revealed that ENMs can provide useful insights into the intrinsic dynamics of large DNA nanocages and represent a useful tool in the field of structural DNA nanotechnology.
Investigation of Drug–Polymer Compatibility Using Chemometric-Assisted UV-Spectrophotometry
Authors: Mohamed Amir , Abd-Motagaly Amr , Ahmed Osama , Amin Suzan , Mohamed Ali Alaa
Published: January 2017

A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios with different sets of drug concentrations were prepared. These were UV scanned initially and after three and seven days of storage at 25 °C. Using the calibration model, the drug recovery percent was estimated and a decrease in concentration of 10% or more from initial concentration was considered to indicate instability. PLS models with PC3 (for Ag) and PC2 (for Ch) showed a good correlation between actual and found values with root mean square error of cross validation (RMSECV) of 0.00284 and 0.01228, and calibration coefficient (R2) values of 0.996 and 0.942, respectively. The average drug recovery percent after three and seven days was 98.1 ± 2.9 and 95.4 ± 4.0 (for Ag), and 97.3 ± 2.1 and 91.4 ± 3.8 (for Ch), which suggests more drug compatibility with an Ag than a Ch polymer. Conventional techniques including DSC, XRD, FTIR, and in vitro minimum inhibitory concentration (MIC) for (1:1) drug–polymer mixtures were also performed to confirm clindamycin compatibility with Ag and Ch polymers.
Stochastic Spatio-Temporal Models for Analysing NDVI Distribution of GIMMS NDVI3g Images
Authors: Militino Ana , Ugarte Maria , Pérez-Goya Unai
Published: January 2017

The normalized difference vegetation index (NDVI) is an important indicator for evaluating vegetation change, monitoring land surface fluxes or predicting crop models. Due to the great availability of images provided by different satellites in recent years, much attention has been devoted to testing trend changes with a time series of NDVI individual pixels. However, the spatial dependence inherent in these data is usually lost unless global scales are analyzed. In this paper, we propose incorporating both the spatial and the temporal dependence among pixels using a stochastic spatio-temporal model for estimating the NDVI distribution thoroughly. The stochastic model is a state-space model that uses meteorological data of the Climatic Research Unit (CRU TS3.10) as auxiliary information. The model will be estimated with the Expectation-Maximization (EM) algorithm. The result is a set of smoothed images providing an overall analysis of the NDVI distribution across space and time, where fluctuations generated by atmospheric disturbances, fire events, land-use/cover changes or engineering problems from image capture are treated as random fluctuations. The illustration is carried out with the third generation of NDVI images, termed NDVI3g, of the Global Inventory Modeling and Mapping Studies (GIMMS) in continental Spain. This data are taken in bymonthly periods from January 2011 to December 2013, but the model can be applied to many other variables, countries or regions with different resolutions.
Rapid Transfer Alignment of MEMS SINS Based on Adaptive Incremental Kalman Filter
Authors: Chu Hairong , Sun Tingting , Zhang Baiqiang , Zhang Hongwei , Chen Yang
Published: January 2017

In airborne MEMS SINS transfer alignment, the error of MEMS IMU is highly environment-dependent and the parameters of the system model are also uncertain, which may lead to large error and bad convergence of the Kalman filter. In order to solve this problem, an improved adaptive incremental Kalman filter (AIKF) algorithm is proposed. First, the model of SINS transfer alignment is defined based on the “Velocity and Attitude” matching method. Then the detailed algorithm progress of AIKF and its recurrence formulas are presented. The performance and calculation amount of AKF and AIKF are also compared. Finally, a simulation test is designed to verify the accuracy and the rapidity of the AIKF algorithm by comparing it with KF and AKF. The results show that the AIKF algorithm has better estimation accuracy and shorter convergence time, especially for the bias of the gyroscope and the accelerometer, which can meet the accuracy and rapidity requirement of transfer alignment.
Low Cost and Flexible UAV Deployment of Sensors
Authors: Sørensen Lars , Jacobsen Lars , Hansen John
Published: January 2017

This paper presents a platform for airborne sensor applications using low-cost, open-source components carried by an easy-to-fly unmanned aircraft vehicle (UAV). The system, available in open-source , is designed for researchers, students and makers for a broad range of exploration and data-collection needs. The main contribution is the extensible architecture for modularized airborne sensor deployment and real-time data visualisation. Our open-source Android application provides data collection, flight path definition and map tools. Total cost of the system is below 800 dollars. The flexibility of the system is illustrated by mapping the location of Bluetooth beacons (iBeacons) on a ground field and by measuring water temperature in a lake.
Experimental Validation of a Wave Energy Converter Array Hydrodynamics Tool
Authors: Mercadé Ruiz Pau , Ferri Francesco , Kofoed Jens
Published: January 2017

This paper uses experimental data to validate a wave energy converter (WEC) array hydrodynamics tool developed within the context of linearized potential flow theory. To this end, wave forces and power absorption by an array of five-point absorber WECs in monochromatic and panchromatic waves were measured from a set of deep-water wave basin experimental tests. Unlike the few other examples of WEC array experimental campaigns, the power take-off (PTO) system of each WEC was simulated by means of advanced equipment capable of accurately reproducing linear control strategies and, thereby, reducing the uncertainty in the physical model. Experimental measurements are then compared with numerical predictions showing reasonable agreement; the measured trends are, in the same way, well captured by the numerical predictions. Further analysis demonstrates that the developed tool can predict, on the safe side, wave forces and power absorption with less than 17.5% and 23.0% error, respectively, for more than 68% of the predictions.
Sprawl Dynamics in Rural–Urban Territories Highly Suited for Wine Production. Mapping Urban Growth and Changing Territorial Shapes in North-East Italy
Authors: Rizzo Luca , Smerghetto Filippo , Lucia Maria , Rizzo Raffaela
Published: January 2017

In Italy, large-scale changes in the structure of land use can be observed. These are caused primarily by socio-economic pressures, generally determining the conversion of agricultural land into artificial surfaces. Our aim was to investigate if and how sprawl dynamics influence viticultural landscapes (that is, if they result in scattered, intermediate, or compact urban developments). We focused on selected territories in North-East Italy, where vine-growing provides almost uninterrupted land cover, as case study areas. Using GIS-based techniques, we documented the processes of land use, analyzing the resulting changes of urban-rural forms and in territorial shapes. Results at the Provincial level showed decreasing dispersed artificial surfaces and increasing clustered urban developments. This trend is also detected in areas under vine, but in general is more modest. Our research indicates that typical agricultural productions can determine resistance to the alienation of land, maintaining a sufficient consistency for areas to develop in a more varied and articulated (for example touristic) manner.
Value Chain Structures that Define European Cellulosic Ethanol Production
Authors: Gregg Jay , Bolwig Simon , Hansen Teis , Solér Ola , Ben Amer-Allam Sara , Pladevall Viladecans Júlia , Klitkou Antje , Fevolden Arne
Published: January 2017

Production of cellulosic ethanol (CE) has not yet reached the scale envisaged by the literature and industry. This study explores CE production in Europe to improve understanding of the motivations and barriers associated with this situation. To do this, we conduct a case study-based analysis of CE production plants across Europe from a global value chain (GVC) perspective. We find that most CE production plants in the EU focus largely on intellectual property and are therefore only at the pilot or demonstration scale. Crescentino, the largest CE production facility in Europe, is also more interested in technology licensing than producing ethanol. Demonstration-scale plants tend to have a larger variety of feedstocks, whereas forestry-based plants have more diversity of outputs. As scale increases, the diversity of feedstocks and outputs diminishes, and firms struggle with feedstock provisioning, global petroleum markets and higher financial risks. We argue that, to increase CE production, policies should consider value chains, promote the wider bio-economy of products and focus on economies of scope. Whereas the EU and its member states have ethanol quotas and blending targets, a more effective policy would be to seek to reduce the risks involved in financing capital projects, secure feedstock provisioning and support a diversity of end products.
Evaluating the Potential of Variable Renewable Energy for a Balanced Isolated Grid: A Japanese Case Study
Authors: Inoue Mai , Genchi Yutaka , Kudoh Yuki
Published: January 2017

There is a global push to develop renewable energy to further a low-carbon society. However, the nature of variable renewable energy (VRE) sources such as wind power and solar photovoltaic (PV) systems may create problems because electricity grids require a stable power supply to match demand. To evaluate the potential capacity of VREs that may be installed, we develop an optimized model that balances power supply and demand and also considers grid balancing by battery storage and load frequency control. The model was applied to a case study of an isolated grid on a remote Japanese island. When set to optimize the grid in terms of lowest cost, the model suggested that, compared with the base case, the capacity of wind power should be increased by a factor of 1.7 and 15.8 for situations without and with battery storage, respectively. Since it was always considered to be more expensive than wind power, no change in solar PV capacity was observed. These approaches resulted in a decrease in the total power generation cost of 2% and 24%, respectively, while total CO2 emissions fell by 3% and 52%, primarily driven by decreased used of the existing fossil-fueled thermal plant.
The Impact of Morphological Features on Summer Temperature Variations on the Example of Two Residential Neighborhoods in Ljubljana, Slovenia
Authors: Fikfak Alenka , Kosanović Saja , Konjar Miha , Grom Janez , Zbašnik-Senegačnik Martina
Published: January 2017

The study conducted in this paper is focused on a predominantly residential area of the City of Ljubljana—Koseze, which is characterized by generally favorable (bio)climatic conditions. Nonetheless, thermal satellite images showed that residential neighborhoods within the Koseze district display unexpected variations in summer temperatures. This observation called into question the benefits of existing bioclimatic features and indicated the need to investigate and compare two neighborhoods with similar urban parameters, with the aim to identify morphological differential characteristics impacting urban heat island (UHI) intensity. By applying the study methodology based on a literature review, surveys of key precedents, detailed mapping in two Koseze locations, in situ measurements, observations and recordings, thermal imagery, and the analyses of statistical data, as well as by defining the four main categories of morphological urban parameters—structure, cover, fabric and metabolism, it was concluded that both neighborhoods have common morphological elements mitigating the UHI effect. Additionally, it was found that the neighborhood with higher UHI intensity has several less favorable features, such as busier roads, larger surface of parking corridors, and the existence of underground parking space. The traffic as an element of urban morphology hence represents the main cause of differences among UHI levels in the two Koseze neighborhoods.
Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez
Authors: Fox Jay , Gutiérrez José
Published: January 2017

Jay W. Fox and José María Gutiérrez recently finished editing a Special Issue on the topic “Snake Venom Metalloproteinases” in Toxins. The Special Issue covers a wide range of topics, including the molecular evolution and structure of snake venom metalloproteinases (SVMPs), the mechanisms involved in the generation of diversity of SVMPs, the mechanism of action of SVMPs, and their role in the pathophysiology of envenomings, with implications for improving the therapy of envenomings. In this interview, we discussed with Jay W. Fox and José María Gutiérrez their research on the SVMPs and their perspectives on the future trends and challenges for studying snake venoms.
Design and Testing of Recharge Wells in a Coastal Aquifer: Summary of Field Scale Pilot Tests
Authors: Guttman Joseph , Negev Ido , Rubin Genadi
Published: January 2017

Surplus water from seawater desalination plants along the Israeli Coast can be injected underground for seasonal storage. Two pilot projects were established to simulate the movement of air bubbles and changes in the well hydraulic parameters during pumping and recharging. The study showed that it is impossible to remove the smaller air bubbles (dissolved air) that are created during the injection process, even when the injection pipe is fully saturated. The pumping tests showed that there were large differences in the well hydraulic parameters between the pumping and the recharge tests despite that they were conducted at the same well. Two mechanisms are responsible for the reduction in the aquifer coefficients during the recharge event. The first mechanism is the pressures that the injected water needs to overcome; the aquifer pressure and the pore water pressure it is supposed to replace at the time of the injection. The second mechanism is the pressure that the injected water needs to overcome the clogging process. It is expressed as the high water level inside the recharge well in comparison to the small rising of the water level in the observation wells. This research gives good insight into the injection mechanism through wells and is essential for any further development of injection facilities and for the operation and management protocols.
Detection and analysis of hazardous locations on roads: a case study of the Croatian motorway A1
Authors: Cvitanić Dražen , Vukoje Biljana
Published: January 2017

The present paper describes research undertaken to identify causes underlying single-vehicle accidents (in terms of road design, driver behaviour and vehicle handling characteristics), which continuously happen in one specific section of Croatian motorway A1. The research resulted in a proposed procedure for a detection of hazardous locations on motorways and analysis of possible causes of single-vehicle accidents. The main part of the procedure involves test-rides with a vehicle equipped with devices (a ball bank indicator and a GPS data logger), which collect data on driver’s behaviour and vehicle handling characteristics (position, speed, longitudinal and lateral acceleration, heading, path radius, etc.). Despite the fact that the motorway was designed in accordance with the design guidelines, test rides performed by higher operating speeds identified two locations with a lateral acceleration change a few times higher than the design value. The collected data are then used for analysing hypotheses about the possible causes of accidents by using a vehicle dynamic model. The hypothesis that a sudden change in lateral acceleration could result in a driver’s inadequate manoeuvre like braking and cause a vehicle accident was analysed with a transient bicycle model. The results of test rides and the transient bicycle model indicate that speed, intensity of deceleration and underinflated tires significantly affect the probability of a single-vehicle accident.
Use of high intensity reflective sheeting in lieu of external lighting of overhead roadway signs
Authors: Ye Fan , Carlson Paul J. , Jackson Mike N.
Published: January 2017

Overhead guide sign lighting has been used by many agencies to improve visibility. However, the availability of newer and more efficient retroreflective materials has created a new challenge for state transportation agencies going through sign sheeting upgrade programs and considering the need for using sign lighting, as there is no existing answer regarding whether upgraded sign sheeting itself can meet drivers’ nighttime visibility demands without external sign lighting. The purpose of the paper is to investigate whether high intensity reflective sheeting can be used to replace overhead guide sign lighting. The conclusion of the study provided a guidance for agencies to adopt their current sign lighting policy. A luminance computation model is used in the paper to calculate overhead guide sign legend luminance under various situations, including different sign lighting technologies, different geometrics and overhead guide sign locations, and different amounts of sign dirt and sign aging. By comparing the calculated luminance of a specific overhead guide sign at a specific situation with the legibility luminance levels required by older drivers, sign lighting needs are assessed. In addition, a life-cycle cost spreadsheet is developed and used to calculate the cost of replacing the current sign sheeting with high reflective sheeting and the cost of installing/upgrading sign lighting. Eventually, the most cost effective approach to maintain overhead guide luminance is discussed.
GAPS IN PROTOPLANETARY DISKS AS SIGNATURES OF PLANETS. III. POLARIZATION
Authors: Jang-Condell Hannah
Published: January 2017

Polarimetric observations of T Tauri and Herbig Ae/Be stars are a powerful way to image protoplanetary disks. However, interpretation of these images is difficult because the degree of polarization is highly sensitive to the angle of scattering of stellar light off the disk surface. We examine how disks with and without gaps created by planets appear in scattered polarized light as a function of inclination angle. Isophotes of inclined disks without gaps are distorted in polarized light, giving the appearance that the disks are more eccentric or more highly inclined than they truly are. Apparent gap locations are unaffected by polarization, but the gap contrast changes. In face-on disks with gaps, we find that the brightened far edge of the gap scatters less polarized light than the rest of the disk, resulting in slightly decreased contrast between the gap trough and the brightened far edge. In inclined disks, gaps can take on the appearance of being localized “holes” in brightness rather than full axisymmetric structures. Photocenter offsets along the minor axis of the disk in both total intensity and polarized intensity images can be readily explained by the finite thickness of the disk. Alone, polarized scattered light images of disks do not necessarily reveal intrinsic disk structure. However, when combined with total intensity images, the orientation of the disk can be deduced and much can be learned about disk structure and dust properties.
THE EFFECT OF AGN FEEDBACK ON THE INTERSTELLAR MEDIUM OF EARLY-TYPE GALAXIES: 2D HYDRODYNAMICAL SIMULATIONS OF THE LOW-ROTATION CASE
Authors: Ciotti Luca , Pellegrini Silvia , Negri Andrea , Ostriker Jeremiah P.
Published: January 2017

We present two-dimensional hydrodynamical simulations for the evolution of early-type galaxies containing central massive black holes (MBHs), starting at an age of

. The code contains accurate and physically consistent radiative and mechanical active galactic nucleus (AGN) wind feedback, with parsec-scale central resolution. Mass input comes from stellar evolution; energy input includes Type Ia (SNIa) and II supernovae and stellar heating; star formation (SF) is included. Realistic, axisymmetric dynamical galaxy models are built solving the Jeans’ equations. The lowest mass models (

) develop global outflows sustained by SNIa heating, ending with a lower amount of hot gas and new stars. In more massive models, nuclear outbursts last to the present epoch, with large and frequent fluctuations in nuclear emission and from the gas (

). Each burst lasts

years, during which cold, inflowing, and hot, outflowing gas phases coexist. The

relation for the gas matches that of local galaxies. AGN activity causes positive feedback for SF. Roughly half of the total mass loss is recycled into new stars (

), just ≃3% of it is accreted on the MBH, the remainder being ejected from the galaxy. The ratio between the mass of gas expelled to that in new stars, the load factor, is

. Rounder galaxy shapes lead to larger final MBH masses,

, and

. Almost all of the time is spent at very low nuclear luminosities, yet one quarter of the total energy is emitted at an Eddington ratio

. The duty-cycle of AGN activity is approximately 4%.
ALMA MEASUREMENTS OF CIRCUMSTELLAR MATERIAL IN THE GQ LUP SYSTEM
Authors: MacGregor Meredith A. , Wilner David J. , Czekala Ian , Andrews Sean M. , Dai Y. Sophia , Herczeg Gregory J. , Kratter Kaitlin M. , Kraus Adam L. , Ricci Luca , Testi Leonardo
Published: January 2017

We present Atacama Large Millimeter/submillimeter Array observations of the GQ Lup system, a young Sun-like star with a substellar-mass companion in a wide-separation orbit. These observations of 870 μm continuum and CO J = 3–2 line emission with beam size ∼0.″3 (∼45 au) resolve the disk of dust and gas surrounding the primary star, GQ Lup A, and provide deep limits on any circumplanetary disk surrounding the companion, GQ Lup b. The circumprimary dust disk is compact with an FWHM of 59 ± 12 au, while the gas has a larger extent with a characteristic radius of 46.5 ± 1.8 au. By forward-modeling the velocity field of the circumprimary disk based on the CO emission, we constrain the mass of GQ Lup A to be M
* = (1.03 ± 0.05) ∗ (d/156 pc) M
⊙, where d is a known distance, and determine that we view the disk at an inclination angle of 60.°5 ± 0.°5 and a position angle of 346° ± 1°. The 3σ upper limit on the 870 μm flux density of any circumplanetary disk associated with GQ Lup b of <0.15 mJy implies an upper limit on the dust disk mass of <0.04 M
⊕ for standard assumptions about optically thin emission. We discuss proposed mechanisms for the formation of wide-separation substellar companions given the non-detection of circumplanetary disks around GQ Lup b and other similar systems.
HARMONIC SPACE ANALYSIS OF PULSAR TIMING ARRAY REDSHIFT MAPS
Authors: Roebber Elinore , Holder Gilbert
Published: January 2017

In this paper, we propose a new framework for treating the angular information in the pulsar timing array (PTA) response to a gravitational wave (GW) background based on standard cosmic microwave background techniques. We calculate the angular power spectrum of the all-sky gravitational redshift pattern induced at the Earth for both a single bright source of gravitational radiation and a statistically isotropic, unpolarized Gaussian random GW background. The angular power spectrum is the harmonic transform of the Hellings & Downs curve. We use the power spectrum to examine the expected variance in the Hellings & Downs curve in both cases. Finally, we discuss the extent to which PTAs are sensitive to the angular power spectrum and find that the power spectrum sensitivity is dominated by the quadrupole anisotropy of the gravitational redshift map.
THE MOUNT WILSON OBSERVATORY S-INDEX OF THE SUN
Authors: Egeland Ricky , Soon Willie , Baliunas Sallie , Hall Jeffrey C. , Pevtsov Alexei A. , Bertello Luca
Published: January 2017

The most commonly used index of stellar magnetic activity is the instrumental flux scale of singly ionized calcium H & K line core emission, S, developed by the Mount Wilson Observatory (MWO) HK Project, or the derivative index

. Accurately placing the Sun on the S scale is important for comparing solar activity to that of the Sun-like stars. We present previously unpublished measurements of the reflected sunlight from the Moon using the second-generation MWO HK photometer during solar cycle 23 and determine cycle minimum

, amplitude

, and mean

. By establishing a proxy relationship with the closely related National Solar Observatory Sacramento Peak calcium K emission index, itself well correlated with the Kodaikanal Observatory plage index, we extend the MWO S time series to cover cycles 15–24 and find on average

,

,

. Our measurements represent an improvement over previous estimates that relied on stellar measurements or solar proxies with non-overlapping time series. We find good agreement from these results with measurements by the Solar-Stellar Spectrograph at Lowell Observatory, an independently calibrated instrument, which gives us additional confidence that we have accurately placed the Sun on the S-index flux scale.