bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Keragaman Pendapatan Usahatani Sayur dan Jagung Hibrida (Studi Kasus Kelompok Tani di Desa Ababi Kecamatan Abang, Kabupaten Karangasem, Provinsi Bali)
Authors: WIRYASTI I DEWA AYU DEVI SAVITRI , ARTINI NI WAYAN PUTU , DEWI NI LUH MADE INDAH MURDYANI
Published: October 2022

Vegetable and Corn Farming (Case Study: Farmer Group in Ababi Village, Abang District, Karangasem Regency, Bali Province). Hybrid vegetable and corn farming is one type of farming activity carried out by the Baja Tani group. In general, farmers do not know how much influence the type of commodity has on their farm income, therefore it is important to observe whether diversity affects their farm income. This study aims to determine the farm income of cultivated hybrid vegetables and corn, this study also aims to determine what constraints affect farming activities and maize and whether the choice of commodity types affect farm income. The results showed that the type of commodity had an effect on farm income. From the results of the ANOVA analysis, it was obtained that the F statistic value of 27,742 > 2,911 and a significance value of < 0.05 where the highest income was obtained by hybrid corn farmers compared to farmers cultivating mustard greens, long beans, and eggplant so that the farmer's choice to cultivate corn was considered appropriate. As for the obstacles faced by farmers, as many as 43% of farmer group members who originally cultivated vegetables experienced problems related to capital and farming cultivation techniques. Marketing constraints 70% of vegetable farmers experienced problems related to marketing channels because one of the vegetable distribution places, namely hotels and villas, had to close due to the pandemic. Changes in price are one of the obstacles felt by all farmers because they experience a decline in prices due to large harvests.
Analisis Pendapatan dan Nilai Tambah Agroindustri Keripik Ayam di Desa Kesiman Petilan, Denpasar Timur
Authors: WIDIANTARI PUTU DEWI , ANTARA MADE , DJELANTIK A.A.A. WULANDIRA SAWITRI
Published: October 2022

Analysys of Income and Added-Value of Chicken Chips Agroindustry in Kesiman Petilan Village, East Denpasar. Covid-19 Pandemic has many impacts on all business actors, either large-scale, small-scale, or medium-scale. The business actors of chicken chips agroindustry are also impacted by the pandemic in terms of production processes and income. This study aims to: (1) Analyze the income of the business actors involved in the chicken chips agroindustry in Kesiman Petilan Village, East Denpasar, (2) Analyze the added-value of the chicken chips products in the agroindustry in Kesiman Petilan Village, East Denpasar, and (3) Identify the problems that have been experienced by the business actors in the chicken chips agroindustry during Covid-19 Pandemic. The analysis technique used was income analysis, added-value analysis, and qualitative descriptive. The results of the study show that: (1) The amount of income in chicken chips agroindustry in Kesiman Petilan Village before Pandemic was IDR 2,785,853.90 while during the Pandemic was IDR 2,066,123.90, (2) The added-value of chicken chips before Pandemic was IDR 10,369.40 while during the Pandemic was IDR 10,114.85, and (3) The agroindustry have faced several problems, including the difficulties to obtain raw materials, the increase of raw materials prices, declining sales, and marketing.
Peningkatan Pendapatan Rumah Tangga Petani melalui Pemanfaatan Pekarangan (Studi Kasus di KWT Madu Serati, Desa Mambang, Kecamatan Selemadeg Timur Tabanan)
Authors: SAVITRI IDA AYU TRISNAYANTI , SUAMBA I KETUT , DEWI IDA AYU LISTIA
Published: October 2022

Increasing household income of farmers through the utilization of yards (Case study of Madu Serati Women Farmer Group, Mambang Village, East Selemadeg District, Tabanan). Food is a basic need and has an important role in life. The government seeks to improve food security through various programs, such as the Sustainable Food House Program that utilizes house yards. This study aims to: (1) calculate the income of female farmers from the sustainable food house program, (2) calculate the contribution of female farmers' income from the sustainable food house program to the total income of farmer households, and (3) determine the motivation of female farmers to manage his yard.This research was conducted in Mambang Village, East Selemadeg District, Tabanan Regency, Bali Province from July to August 2020. The data collected were quantitative and qualitative data with primary and secondary data sources. The collected data were analyzed using both descriptive quantitative and qualitative methods. The determination of 30 samples of members of the women farmer group was conducted using non probability technique with census method. The variables measured in this study were income, contribution of income from yard and the motivation of members of the women farmer group in farming. The result shows that the average income that resulted from yard farming is IDR 2,666,196.67 with a very low contribution to total income, namely 2.75% and the motivation of the women farmer group members in working is to meet physiological needs, security needs, social needs, and appreciation needs. It is necessary to increase the number and types of vegetable crops that have high economic value.
Persepsi Petani terhadap Penggunaan Rice Transplanter di Subak Guama Kecamatan Marga, Kabupaten Tabanan
Authors: PUTRA KETUT ADI WAHYU , ANGGRENI I G A LIES , WINDIA I WAYAN
Published: October 2022

Farmers' Perceptions on the Use of Rice Transplanters in Subak Guama, Marga District, Tabanan Regency. Farmers in Subak Guama are still planting rice manually with human labor. The shortage of rice planting workers began to occur in several rice production centers. Most rice lands can still be planted manually, but the completion is usually not on time. The use of rice transplanter has the potential to solve this problem. Farmers' perceptions of rice transplanter technology need to be known in advance so that the implementation of the rice transplanter program can be sustainable. This study aims to identify the perceptions of Subak Guama farmers in Marga District, Tabanan Regency on the use of transplanters. The analytical method used is descriptive qualitative. Based on the results of research and discussion, it can be concluded that most farmers agree with the use of rice transplanters with a percentage of 76.46 percent. Based on indicators of the nature of using rice transplanter technology, 77.18 percent of farmers agreed; based on indicators of target or rice transplanter users, 75.76 percent of farmers agreed; based on indicators of target attitudes or rice transplanter users, 75.67 percent of farmers agreed; and based on indicators of target or user behavior 76.78 percent of farmers agreed. attitude indicator or rice transplanter users was 75.67 percent included in the agree category and the target behavior indicator or rice transplanter users with 76.78 percent achievement fall into the agree category.
Partisipasi Kelompok Wanita Tani Sedana Amerta Sari pada Program Pekarangan Pangan Lestari (Studi Kasus Desa Angantaka, Kecamatan Abiansemal, Kabupaten Badung)
Authors: SARI NI KADEK AYU PUTRI DITA , PITANA I GDE , SARJANA I MADE
Published: October 2022

Participation of Members of Sedana Amerta Sari Women Farmer Group in Sustainable Food Yard Program: Case Study of Angantaka Village, Abiansemal District, Badung Regency. The Sustainable Food Yard Program has the potential to achieve food self-sufficiency. The development of the program requires active participation of farmers. This study aims to analyze the level of participation, describe the forms of participation and the obstacles faced by the Sedana Amerta Sari Women Farmer Group (KWT). The research was conducted in the village of Angantaka and involved 30 respondents who are members of KWT. Data collection was carried out using a combination of in-depth interview techniques, observation and documentation to describe the forms and constraints of participation. Survey was carried out to determine the level of KWT participation. The data were then analyzed using descriptive qualitative methods. The result shows that the participation of KWT members is at a moderate level in all indicators of research variables such as participation in decision making, program implementation, program monitoring and utilization of results (56.16%). In terms of technical aspect, participation constraints faced by KWT include the lack of management time, the presence of pests and diseases, the unavailability of electricity and clean water on the demonstration plot. Economically, KWT members are facing capital constraints for the maintenance and development of agrotourism. Finally, the KWT lacks solidarity and internal group communication in terms of social aspects.
Analisis Usaha Pengolahan Indutri Batu Bata dan Dampaknya terhadap Penyusutan Lahan Sawah di Desa Nyitdah Kecamatan Kediri Kabupaten Tabanan
Authors: DEWI NI KOMANG NITA , ANTARA MADE , WIDHIANTINI WIDHIANTINI
Published: October 2022

Analysis of Brick Processing Business and Its Impact on Rice Lands Conversion in Nyitdah Village, Kediri District, Tabanan Regency. The brick industry includes a production process that converts clay into other products that have more usability. This study aims to identify the brick production process, analyze the income and feasibility of the brick processing business, and the impact of brick processing business on rice land conversion. The research location was determined purposely, namely Nyitdah Village, Kediri District, Tabanan Regency. Most people in the village work in the brick processing business and the business could be considered as a small industry. The 61 samples were determined by using simple random sampling method. The data used in this study are primary and secondary data. The results show that the brick processing business is efficient and modern. Total net income from the brick industry is IDR 9,274,499.00 / month. The brick processing business seems feasible, considering the R / C Ratio > 1 and the BEP is less than the amount of production and the price in Nyitdah Village. However, the business has an impact on rice land conversion due to the construction of brick processing plants in rice cultivated lands. The average rice land conversion that occurs in Nyitdah Village is 0.4 ha / year.
Faktor- Faktor yang Berpengaruh terhadap Produksi Selada Daun (Lactuca sativa var. crispa L) di Desa Baturiti, Kecamatan Baturiti, Kabupaten Tabanan
Authors: DEWI NI PUTU RAHAYU CHANDRA , DEWI RATNA KOMALA , SARJANA DEWA GEDE RAKA
Published: October 2022

Factors Affecting the Production of Lettuce (Lactuca sativa var.crispa L) in Baturiti Village, Baturiti District, Tabanan Regency. Lettuce (Lactuca sativa L) is a horticultural commodity that has high economic value. Lettuce can grow well if planted in an environment that suits its variety. Baturiti District is known as a lettuce-producer region. However, lettuce production has fluctuated due to inefficiency problems that are related with production inputs. This study aims to determine the factors that influence the lettuce production and the allocative efficiency to determine whether the use of production input factors is efficient or not in terms of price. The research was conducted in Baturiti Village by analyzing production factors such as arable land, seeds, manure, liquid pesticides, and labor using the Cobb-Douglass production function. Analysis was conducted by using data from the September to November 2019 planting season. The result shows that production factors such as arable land, manure and pesticides have a significant effect on lettuce production. The factors of seed production and labor do not have a significant effect on lettuce production. The use of manure and liquid pesticides is not efficient yet and must be added. The addition must meet the principles of “five right” for manure and “six right” for liquid pesticides in order to produce maximum profit.
Kinerja Finansial Usaha Distribusi Sayur (Studi Kasus: Wijaya Vegetables di Kecamatan Baturiti Kabupaten Tabanan Provinsi Bali)
Authors: WIJAYAKUSUMA I PUTU YUDHI ARTA , ANTARA I MADE , SUTARI NI WAYAN SRI
Published: October 2022

Financial Performance Of Vegetable Distribution Business (Case Study: Wijaya Vegetables In Baturiti District, Tabanan Regency, Bali Province). One of the current problems in the agricultural sector is unjust trade caused by long supply chains. Wijaya Vegetables has succeeded in innovating to shorten the market chain so that its business model and financial analysis are important to be understood. Wijaya Vegetables is a sociopreneurship that distributes fresh vegetables directly from farmers in Baturiti District, Tabanan Regency, Bali Province. Financially, Wijaya Vegetables has a relatively increased profit. Asset composition which is dominated by current assets shows good business activity. The R/C ratio value of 1.28 indicates that the business is financially viable, and the average monthly profit margin of 40% indicates that the business has healthy growth. The allocation of profits used for social aspects should be reconsidered considering the amount is quite large. Utilization of debt should also be maximized. Further research that discusses the social aspects and business model of Wijaya Vegetables is important to do.
Isolated deep femoral artery plasty in the management of peripheral arterial disease
Authors: Kebriakov A. V. , Svetlikov A. V. , Gamzatov T. Kh. , Shapovalov A. S. , Khubulava G. G. , Kashchenko V. A. , Ratnikov V. A.
Published: October 2022

In chronic lower limb ischemia, the deep femoral artery plays a significant role in compensating for blood circulation due to the developed collateral branches providing the blood supply to the entire limb when a superficial femoral artery occluded. Surgical plasty of the deep femoral artery, profundaplasty, has been established as a technique having long-term patency results, significantly superior to bypass operations on the femoral-popliteal-tibial segment, as well as endovascular operations. However, the clinical effectiveness of isolated deep femoral artery is often questioned, especially in patients with critical ischemia. Nowadays there are no instrumental methods to reliably assess the quality of collaterals preoperatively. The article provides an overview of published data concerning different methods of profundaplasty improving effectiveness of surgical strategy through various technical modifications. Also it is introduced the role of the plain balloon angioplasty and stenting of the deep femoral artery. It also describes existing methods for isolated profundoplasty effectiveness preoperative evaluation.
Morphofunctional state of microglia and hippocampal neurons in aged rats after anesthesia with chloral hydrate
Authors: Shcherbak N. S. , Yukina G. Yu. , Gurbo A. G. , Sukhorukova E. G. , Sargsian A. G. , Thomson V. V. , Galagudza M. M.
Published: October 2022

Introduction. Successful translating of the fundamental research results into clinical practice is determined by a sufficiently large number of components, including the age of experimental animals and the anesthesia used. Chloral hydrate is often used as an anesthetic in preclinical studies, while its effect on the morphofunctional characteristics of the hippocampus in aged animals remains unexplored, which can lead to significant distortion and incorrect interpretation of the obtain results. Objective – morphofunctional assessment of the neurons and microglia in the layers of CA1, CA2, CA3 and CA4 fields of the hippocampus in aged rats anesthetized with chloral hydrate. Materials and methods. Male Wistar rats at the age of 24 months were anesthetized with chloral hydrate (400 mg/kg). In the early (2 days) period after chloral hydrate anesthesia, the morphofunctional state of neurons and the reaction of microglia were qualitatively and quantitatively assessed by histological, immunohistochemical, and morphometric analysis in the marginal, pyramidal, and molecular layers of fields CA1, CA2, CA3, and CA4 of the hippocampus. Results. 48 hours after 24-month-old Wistar rats were anesthetized with chloral hydrate, changes in the morphofunctional state of the pyramidal layer of the hippocampus were shown to be characterized by a significant decrease in the number of neurons in fields CA1 and CA3 with two nucleoli by 42 and 54 %, respectively, and a decrease in the width of the layer of fields CA1 and CA3 and CA4 by 27, 29 and 21 %, respectively, compared with similar indicators in the control group (P<0.05). In all layers of fields CA1, CA2, CA3 and CA4 of hippocampus, microglia reacted by the transformation of Iba-1-positive microgliocytes body and processes and a significant increase of the Iba-1 protein expression compared to the animals without administration of chloral hydrate (P<0.05). Conclusions. A single chloral hydrate dose administration necessary to anesthetized the aged Wistar rats without model surgery leads to morphofunctional changes in neurons in the most vulnerable fields of the hippocampus with simultaneous activation of microglia in all fields. This circumstance must be taken into account when conducting basic research and preclinical studies.
Pemeriksaan SDIDTK sebagai Skrining Kejadian Stunting
Authors: Suraida Salat Sri Yunita , Andrian Maulana Widi
Published: October 2022

Stunting adalah kondisi dimana anak mengalami gangguan pertumbuhan jika dibandingkan dengan ukuran normal berdasarkan usianya. Kejadian stunting saat ini di Indonesia masih cukup tinggi. Prevalensi di Jawa Timur sampai pada April 2018, sebanyak 26,7 % kejadian stunting. Angka tersebut dapat memberikan arti bahwa di jawa timur masih cuukup banyak balita yang mengalami stunting. Dan wilayah kabupaten Sumenep memiliki peringkat ke-dua tertinngi di jawa timur dengan jumlah prevalensi kejadian stuntingnya adalah 52,44 %. Selanjutnya Belum ada data terbaru tentang kejadian stunting di Kabupaten Sumenep sampai di akhir tahun 2018. Oleh karena itu, perlu adanya pencegahan serta skrinig terhadap kejdian stunting. Tujuan dilakukannya kegiatan pemeriksaan ini sebagai salah satu bentuk skrining pendeteksian kejadian stunting di Kabupaten Sumenep. Metode pelaksanaan yang digunakan dalam pengabdian kepada masyarakat ini yaitu melakukan pemeriksaan SDIDTK secara langsung kepada anak-anak TAUD SAQU cabang Sumenep sejumlah 71 anak. Dari hasil pemeriksaan tidak ditemukan anak yang mengalami stunting, namun ada 3 orang anak dalam katagori sangat kurus sehingga diperlukan adanya perhatian khusus dari wali murid terhadap asupan nutrisi anak tersebut agar tidak mengarah pada stunting. Hasil pemeriksaan dapat dijadikan refrensi tentang status tumbuh kembang anak-anak TAUD SAQU cabang Sumenep.
Social Determinants of Health and Psychosocial Stressors in the Control of Arterial Hypertension in the Elderly in Countries with Medium and Low Economic Income
Authors:   Universidad Del Valle, Galvis-Acevedo Sebastian
Published: October 2022

We recently published a secondary analysis of a population survey conducted among the elderly population in Colombia between 2015 and 2016, in which we found that age over 74 years and residence in a rural area were variables associated with poorer control of diabetes. Blood pressure in non-institutionalized older adults in Colombia
ألواح فخارية غير منشورة من المتحف العراقي من العصر البابلي القديم
Authors: Mahmoud Al- Juma'a Rasha Abdel Wahab , Daoud Al-Hayali Ali Ghanem Hussein
Published: October 2022

يدرُس البحث ألواحا فخارية غير منشورة من المتحف العراقي تعود بتاريخها إلى العصر البابلي القديم، وهي أربعة ألواح، إذ تناولت مشاهد دينية بحتة مع اختلاف المضمون، تمثل اللوح الأول امرأة عارية متعبدة، واللوح الثاني الآلهة أنثوية (الداعية)، واللوح الثالث يدل على رجل متعبد أما اللوح الرابع فان المشهد يدل على رجل يقدم القرابين.
تعد هذه الألواح نوعا من ضروب الفن، يضم في ثناياه مفاهيم وعقائد تحلى بها سكان بلاد الرافدين ولاسيما أن الغاية من صناعتها لم تكن غاية جمالية مثلما هي لدينا في الوقت الحاضر من امتلاك قطع فنية، بل كان الوازع الاساسي في اقتنائها هو أشبه بالتميمة أو الحرز الذي يمنح الفرد نوعاً من الطمأنينة والراحة النفسية من وجهة نظر مالكها.
Ischiogluteal bursitis: A not to be forgotten differential of gluteal lesions with fluid-fluid levels
Authors: Prakash Adity , Verma Ashish , Singh Pramod K. , Kumar Ishan
Published: October 2022

Ischiogluteal bursitis, also called “weaver’s bottom,” arises due to chronic irritation of the soft tissues overlying the ischial tuberosity. Here, we report a case, in which multiple fluid-fluid levels were seen in a patient with bilateral ischiogluteal bursitis. The previous studies have suggested that ischiogluteal bursitis presents as a cystic lesion at its characteristic location. However, the presence of multiple fluid-fluid levels within the inflamed bursa may confuse young radiologists. To make things worse, a list of differentials for soft-tissue lesions with fluid-fluid levels often omits this common yet often overlooked condition.
Dampak Pembelajaran Kewirausahaan, Media Sosial Terhadap Minat Berwirausaha Siswa SMK Trunojoyo Jember
Authors: Andrie Wijaya Shendy , Neviyani Neviyani , Masari Ervin Nurah
Published: October 2022

Penelitian ini dilatarbelakangi adanya pembelajaran kewirausahaan dan media sosial yang dilakukan oleh pihak sekolah. Adanya hal tersebut menunjukkan adanya peningkatan pada minat berwirausaha siswa. Sehingga tujuan penelitian menganalisis dampak pembelajaran kewirausahaan, media sosial terhadap minat berwirausaha siswa. Dari data primer yang diperoleh dari kuesioner yang dibagikan kepada siswa kelas XII SMK Trunojoyo Jember. Sampel yang digunakan berjumlah 75 responden siswa kelas XII BDP. Jenis pendekatan kuantitatif serta metode analisis regresi linear berganda. Uji t dan uji f dengan taraf nilai α = 5% digunakan untuk menguji hipotesis penelitian. Dari hasil penelitian uji t pembelajaran kewirausahaan terhadap minat berwirausaha memiliki nilai 10,610 > 1,6660, sedangkan media sosial terhadap minat berwirausaha memiliki nilai 15,826 > 1,6660. Serta taraf signifikansinya 0,000, sehingga ada pengaruh secara signifikan secara parsial.  Selanjutnya secara simultan variabel independen (pembelajaran kewirausahaan dan media sosial) dalam penelitian ini memiliki nilai 20,145 > 3,12 sehingga terdapat pengaruh signifikan terhadap variabel dependen yaitu minat berwirausaha pada siswa
Flood Hazard and Risk Assessment of Deoha River Basin, Central Ganga Plain, India: An GIS approach
Authors: Gautam Pawan Kumar , Singh Dhruv Sen
Published: October 2022

Flood is a natural disaster worldwide and it occurs primarily in any plain area due to geological and environmental phenomena like geomorphological process, monsoonal effect, lithology etc. Such plains are also severely affected often by catastrophic flooding and are currently recommended to be the worst flood-affected region in the world. This research aims to classify the flood-prone areas of the Deoha River basin based on the weighted overlay assessment method using Arc-GIS-10 and ERDAS-14. by multi-criteria assessment, in which weights are assigned for each class based on multi parameters with restricted variables to prepare a map of the flood-prone areas. The average annual rainfall (80-200 cm), stream frequency (0.0001 to 0.3563 stream number/km2), slope (0-50-350), drainage density (0-545.94 magnitude/m2), channel gradient (0.27-22.52 m/km), landuse/landcover (cropland>water bodies>built-up>scrubland >forest.) and soil type (loam>sand>clay) prefer the susceptibility of flood-prone in the basin area. The weighting maps are generated by providing ranks and weights to these thematic maps. As a result, the flood hazard risk zonation map would show the total area vulnerable to hazards as very medium, low, moderate, high and very high-risk regions. By creating a risk zonation map, we will recommend measures to reduce the danger of these hazards in Deoha basin.
Nouvelle observation de Geoica mimeuri (Gaumont 1930) et description de Forda riccobonii (Stefani 1899) sur Pistacia atlantica Desf. en Algérie
Authors: Louzabi Siham , Belhadj Safia , Merbah Kamel Zinel Abidine , Brague Nadia Bouragba
Published: October 2022

Ce travail porte sur la caractérisation morphologique des galles foliaires et des pucerons responsables de leur formation sur Pistacia atlantica. Des feuilles présentant des galles ont été prélevées sur des arbres adultes localisés dans un peuplement naturel de P. atlantica, situé à Ain Ousserra dans la région de Djelfa, en Algérie. Les galles échantillonnées ont été classées selon leur forme puis leurs fréquences relatives ont été calculées. Une étude morphométrique de ces galles a, également, été réalisée. Des pucerons ailés issus des galles ont été montés sur lames et lamelles puis observés sous microscope optique pour être déterminés puis mesurés (15 caractères). Deux formes de galle, une forme globuleuse provoquée par le puceron Geoica mimeuri (Gaumont 1930) (espèce signalée pour la première fois en Algérie) et une deuxième, en croissant, provoquée par Forda riccobonii (Stefani 1899) ont été déterminées. La fréquence des galles causées par G. mimeuri est environ trois fois plus élevée que celles induites par F. riccobonii. La longueur, le diamètre minimal et maximal des galles de G. mimeuri sont respectivement de 1,38 cm, 1,12 cm et 1,51 cm. La longueur et la largeur des galles de F. riccobonii sont respectivement de 3,37 cm et 0,93 cm. La description morphométrique des pucerons ailés est également précisée dans l’article.
La pratique de l’entomologie du terrain au conservatoire ou l’essentiel est de bien transmettre
Authors: Fagot Jean , Bortels Jeannine , Dekoninck Wouter
Published: October 2022

Les principes et conventions concernant la récolte, la mise à mort, le traitement, la préparation et le classement des insectes en collection sont abordés dans cette note. Une attention particulière pour l’étiquetage des insectes ainsi que des éléments s’y rapportant sont rappelés dans le but d’harmoniser les pratiques et de corriger les dérives observées au cours du temps.
PENGARUH E-LEARNING DENGAN TTS BERBASIS HOT POTATOES TERHADAP HASIL BELAJAR SISTEM EKSKRESI KELAS XI
Authors: Tri Nugraheni Angelina Vanny , Ningsih Kurnia , Wahyuni Eko Sri
Published: October 2022

The aim of this research is to find out the effect of online learning using HotPotatoes application based crossword puzzle on students learning outcomes onthe structure and function of the human excretory system in class XI SMA SantoFransiskus Asisi. The research’s form is Pre-Experimental Design with OneGroup Pretest-Posttest research design. The sample used in this research is XIMIA class in SMA Santo Fransiskus Asisi, which amounts to 13 students.Sampling using Saturated Sampling technique. Data collection was using pre-test and post-test questions in the objective form. The results showed that meanscore of student learning outcomes before using the Hot Potatoes applicationbased crossword puzzle was 14,46 and mean score of student learning outcomeafter using Hot Potatoes application based crossword puzzle of 18,15. The priceof Wilcoxon match pairs test with SPSS 22 programs is obtained 0,001 whichindicates that there is an effect of online learning using Hot Potatoesapplication based crossword puzzle on students learning outcomes on thestructure and function of the human excretory system in class XI SMA SantoFransiskus Asisi.Keywords: Crossword Puzzles, Excretory System, Hot Potatoes, LearningOutcomes, Online Learning.
Src kinase app: valid inhibitor generation and prediction with explanation using predictive model and selfies
Authors: Abd Elaleem Mohamed
Published: October 2022

Dealing with a small Experimental dataset using a generative model produces a model with underfitting and reduces its ability to generate a new valid compound. Even in the presence of free available chemical databases SMILES string has to use a complex and computationally intensive model to solve validation problems. SELFIES solve all validation problems but further activity optimization is needed with the absence of an app that records molecules generated. In this study, the author uses a predictive model to provide a dataset by a virtual screen of 3 million compounds from a chemical online database in addition to experimental active dataset. Data feed to a different model of one layer Recurrent Neural Network model using both SELFIES and SMILES for about 2-4 epochs. Structure-based drug design was used and Src Kinase as a target to validate both the predictive model and compounds produced by Recurrent Neural Network and further filtration happens using Molecular Dynamics Simulation. SELFIES outperform SMILES in producing valid molecules in all types of Recurrent Neural Network simple structures. Recurrent Neural Network can produce active compounds using the GRU layer without any activity optimization from just 4 runs 100 molecules each. The novelty of the result can be compared to the result coming from predictive model virtual screen data. Recurrent Neural Network can produce novel compounds with key interaction residue with the target protein. All Predictive Models were deployed and ExplainableAI is used to guide generated molecules. MERN stack app SaveMol is used to save molecules produced with substructure research ability and apps links provide here(https://github.com/phalem/Src).
Benchtop 19F nuclear magnetic resonance spectroscopy enabled kinetic studies and optimization of the synthesis of carmofur
Authors: Wang Xina , Vu Julia , Luk Charissa , Njoo Edward
Published: October 2022

Carmofur, a 5-fluorouracil derivative, was initially developed as an antineoplastic agent to treat colorectal cancer. Through drug repurposing efforts, it has been identified as a potent covalent inhibitor of the main protease of SARS-CoV-2 (Mpro), making it a promising therapeutic agent against COVID-19. However, previous synthetic procedures suffer from low yields, or long reaction times. In this study, benchtop 19F nuclear magnetic resonance spectroscopy (NMR) enables the real-time quantitative monitoring and characterization of the synthesis of carmofur by providing kinetic insight. Furthermore, its proton lock capabilities no longer require the use of deuterated solvents, and has enabled convenient, and rapidly scalable synthesis of our compound. Here, we present the application of benchtop 19F NMR as an efficient method for optimizing the synthesis of carmofur and its future application in the synthesis of related 5-FU analogs.
Porphyrin Metalla-Assemblies Coupled to Cellulose Nanocrystals for PDT and Imaging Applications
Authors: Simões João , Wagnières Georges , Sarpaki Sophia , Sol Vincent , Therrien Bruno
Published: October 2022

Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer types. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactive oxygen species (ROS) inside cells, which leads to their destruction. In addition, the luminescence properties of photosensitizers can be exploited to develop imaging tools. Unfortunately, the cancer selectivity and homogeneity of most photosensitizers are frequently limiting the performances of PDT and cancer detection/characterization by luminescence imaging. Consequently, our study aims to use cellulose nanocrystals to transport and deliver radiolabeled photo-responsive metalla-assemblies to create a new generation of theranostic agents for PDT and imaging applications. The synthesis, structural characterization, cytotoxicity evaluation, and in vivo biodistribution imaging of the compounds are presented. The best candidates show excellent biological activity and selectivity towards ovarian carcinoma cell line (A2780), cisplatin resistant ovarian carcinoma cell line (A2780cis) versus normal human embryonic kidney cells (HEK293T), as well as efficient imaging properties, suggesting a potential use as multimodal theranostic agents.
Intrinsic Bond Strength Index as a halogen bond interaction energy predictor
Authors: Šivickytė Ona , Costa Paulo J.
Published: October 2022

Halogen bonds (XBs) have become increasingly popular over the past few years with numerous applications in catalysis, material design, anion recognition, and medicinal chemistry. To avoid a \textit{post factum} rationalization of XB trends, descriptors can be tentatively employed to predict the strength of potential halogen bonds. These typically comprise the electrostatic potential maximum at the tip of the halogen, ${V_{S, max}}$, or properties based on the topological analysis of the electronic density. However, such descriptors either can only be used with confidence for specific families of halogen bonds or require intense computations and, therefore, are not particularly attractive for large datasets with diverse compounds or biochemical systems. Therefore, the development of a simple, widely applicable, and computationally feasible descriptor remains a challenge as it would facilitate the discovery of new XB applications while also improving the existing ones. Recently, the Intrinsic Bond Strength Index (IBSI) has been proposed as a new tool to evaluate any bond strength, however, it has not been extensively explored in the context of halogen bonding. In this work, we show that IBSI values linearly correlate with the interaction energy of diverse sets of halogen-bonded complexes and therefore, can be used to quantitatively predict halogen bond strength. The linear fit models based on quantum-mechanics-based electron density provided MAEs typically below 1~kcal~mol$^{-1}$. Moreover, we also explored the exciting possibility to use a promolecular density approach (\pro{}), which only requires the complex geometry as an input which is computationally cheap. Surprisingly, the performance was comparable to the QM-based methods, thus opening the door for the usage of \pro{} as a fast, yet accurate, XB strength descriptor in large datasets but also in biomolecular systems such as protein--ligand complexes.
Solid-phase synthesis of cereblon-recruiting selective histone deacetylase 6 degraders (HDAC6 PROTACs) with anti-leukemic activity
Authors: Sinatra Laura , Yang Jing , Schliehe-Diecks Julian , Dienstbier Niklas , Vogt Melina , Gebing Philip , Bachmann Luisa M. , Sönnichsen Melf , Lenz Thomas , Stühler Kai , Schöler Andrea , Borkhardt Arndt , Bhatia Sanil , Hansen Finn K.
Published: October 2022

In this work, we utilized the proteolysis targeting chimera (PROTAC) technology to achieve the chemical knock-down of histone deacetylase 6 (HDAC6). Two series of cereblon-recruiting PROTACs were synthesized via a solid-phase parallel synthesis approach, which allowed the rapid preparation of two HDAC6 degrader mini libraries. The PROTACs were either based on an unselective vorinostat-like HDAC ligand or derived from a selective HDAC6 inhibitor. Notably, both PROTAC series demonstrated selective degradation of HDAC6 in leukemia cell lines. The best degraders from each series (denoted A6 and B4) were capable of degrading HDAC6 via ternary complex formation and the ubiquitin−proteasome pathway, with DC50 values of 3.5 and 19.4 nM, respectively. PROTAC A6 demonstrated promising antiproliferative activity via inducing apoptosis in myeloid leukemia cell lines. These findings highlight the potential of this series of degraders as effective pharmacological tools for the targeted degradation of HDAC6.
Research progress of electrospray ion source principle
Authors: luo jiehong
Published: October 2022

The theory of ion source is of great significance to the design and development of ion source, the slow development of this restricts the design and development of ion source, which makes the ion source meet many bottlenecks from laboratory to commercialization. By introducing ion evaporation model (IEM), charged residue model (CRM), chain ejection theory, Zhu yixin's experiment and theory, ion migrate and transport, the paper summarizes the recent research progress in this field, and looks forward to the development of this kind research.
Crystallographic and Computational Analysis of Solid Form Landscape of Three Structurally Related Imidazolidine-2,4-dione Active Pharmaceutical Ingredients: Nitrofurantoin, Furazidin and Dantrolene
Authors: Trimdale-Deksne Aija , Kons Artis , Orola Liāna , Mishnev Anatoly , Stepanovs Dmitrijs , Mazur Liliana , Skiba Magdalena , Dudek Marta K. , Fantozzi Nicolas , Virieux David , Colacino Evelina , Bērziņš Agris
Published: October 2022

We present a crystallographic and computational study of three hydantoin-based active pharmaceutical ingredients nitrofurantoin, furazidin, and dantrolene aimed at identifying factors resulting in different propensities of these compounds to form polymorphs, hydrates, solvates, and solvate hydrates. This study is a continuation of our research towards understanding how small structural differences in closely related compounds affect their propensity to form different crystal phases, as all three compounds contain an imidazolidine-2,4-dione scaffold and a N-acyl hydrazone moiety and all form multiple crystalline phases. Crystallographic and computational analysis of the already known and newly obtained nitrofurantoin, furazidin and dantrolene crystal structures was performed by dissecting the properties of individual molecules and searching for the differences in tendency to form hydrogen bonding patterns and characteristic packing features. The propensity to form solvates was found to correlate with the relative packing efficiency of neat polymorphs and solvates and the ability of molecules to pack efficiently in several different ways. Additionally, the differences in propensity to form solvate-hydrates were attributed to the different stability of the hydrate phases.
Modelamiento de tópicos utilizando mensajes de Twitter relacionados al cáncer cervical
Authors: Reátegui Rojas Ruth María
Published: October 2022

El cáncer cervical es un problema de salud mundial que genera una gran cantidad de información que circula por las redes sociales. El modelado de tópicos permite automáticamente identificar aquellos que tratan sobre un tema en un conjunto de documentos. En el presente trabajo se ha aplicado el modelamiento de tópicos para identificar los tópicos de un conjunto de tuits que tratan sobre al cáncer cervical. Se aplicó el algoritmo LDA y la métrica de la coherencia para la evaluación. Se identificaron siete tópicos relacionados con el efecto de las vacunas contra el VPH, la relación que existe entre el VPH y otras enfermedades, las formas de prevención como vacunas y test de Papanicolaou, programas que prestan servicios médicos para la prevención y eliminación de esta enfermedad, historias de mujeres que han padecido de cáncer cervical y estudios dirigidos a mujeres latinas.
EFFECT OF FOLIAR FERTILIZING ON THE YIELD OF SOME ALMOND CULTIVARS GROWN IN NORTH MACEDONIA
Authors: Stojanova Marina Todor , Djukic Dragutin , Stojanova Monika , Ivanovski Igor , Şatana Aziz
Published: October 2022

The aim of this study was to determine the effect of foliar fertilizing with different fertilizers on the yield of feranjez, texas and primorski almond cultivar, grown in Valandovo region, North Macedonia. The variants were: 1. Control (untreated); 2. Ever green with Me (55% organic matter, 2% w/w Mg, 2% w/w Fe, 2% w/w Zn, 2% w/w Mn, 0.5 % w/w Cu, 0.5% w/w B); 3. Biolinfa (34% organic matter 3% N, 5.80% K2O); 4. Oligomix (1.20% B, 0.10% Cu, 4% Fe, 1.50% Mn, 0.10% Mo, 2% Zn). Total 240 plants per cultivar were included. At the end, soil fertilizing with the fertilizer Polyfeed 11-44-11+ME (Fe, B, Zn, Mn, Co, Mo) was done (450 kg/ha). Before setting up the experiment, soil agrochemical analyses were done and good fertility with nitrogen and potassium, while medium fertility with phosphorus was determined. The foliar fertilizing had a positive influence on the yield of analyzed almond cultivars. The highest average content of fruit yield (2794 kg/ha for feranjez cultivar, 2699 kg/ha for texas cultivar and 2781 kg/ha for primorski cultivar) and the highest average kernels yield (1079 kg/ha for feranjez cultivar, 1333.50 for texas cultivar and 1257.30 kg/ha for primorski cultivar) were determined in the variant 2 treated with the fertilizer Ever green with Me. This study explored and determined how to achieves minimization of economic losses, but also ecological production and preservation of the environment, on the other hand, and all of that with proper use of foliar fertilizers.
THE EFFECT OF ORGANIC AND INORGANIC FERTILIZER ON THE GROWTH AND QUALITY OF PEPPERMINT
Authors: Olumide Joel Kayode
Published: October 2022

The purpose of this study is to examine the effects of organic and inorganic fertilizers on the growth and quality of peppermint (Mentha piperita). The field experiment was carried out in randomized complete block design with 3 treatments and 4 replicates in the Federal University of Agriculture, Abeokuta in 2017. Treatments were: 1- control, 2- sunshine organic fertilizer, 3- urea. Peppermint vine cuttings of 10cm were planted into 12 tilled beds (8m2) with Sunshine organic fertilizer applied two weeks before planting on four beds and Urea applied two weeks after planting on four beds and four beds devoid of any fertilizer application. The result showed that the Application of Sunshine organic fertilizer and Urea significantly enhanced vegetative growth parameters. The effect was maximal with the application of Sunshine organic fertilizer with respect to the number of leaves, the number of tendrils, fresh weight, and dry weight as compared with the application of Urea and Control. The result also showed that Control produced better proximate content as compared with the application of Sunshine organic fertilizer and Urea. However, the application of Urea and Control produced better mineral content as compared with the application of Sunshine organic fertilizer. Application of Sunshine organic fertilizer produced better phytochemical content in the peppermint leaves as compared with the application of Urea and Control. The effect was maximal with the application of Sunshine organic fertilizer with respect to Tannin, Flavonoids, and Saponin as compared with the application of Urea and Control.
EFFECT OF DIFFERENT CONCENTRATION OF ETHREL ON GERMINATION OF SUNFLOWER SEEDS (Helianthus annuus L.) AT BHARATPUR, CHITWAN, NEPAL
Authors: Shahi Keshar Bahadur , Dhakal Suman
Published: October 2022

The research was carried out on “Effect of different concentrations of ethrel on germination of sunflower seed at the Agronomy laboratory in Nepal Polytechnic Institute, Bharatpur, Chitwan from December 2015 to January 2016. The experiment was laid out in Completely Randomized Design (CRD). In the present investigation, seed samples of sunflower (Helianthus annuus) variety viz. Modern Dwarf was collected from the National Oil Research Program (NORP) Nawalpur, Sarlahi for the experiments. Soaking of seeds in water, seed treatment with ethrel (@0.3ml/lit and 0.4ml/lit concentration), hot water treatment, mechanical clipping and control (without treatment) were done to see their effect on the germination of sunflower seed. The recorded parameters among the sampled seeds were germination percentage, root length, shoot length, fresh weight and dry weight. The seeds soaked for 12 hours germinated maximum (100.00%) and seeds that are boiled in water for 15 minutes germinated minimum (4.8%) on the 3rd, 6th and 9th days of observation. Maximum root and shoot length of germinated seed was found in seeds without treatment i.e. 8.5cm & 5.575 cm and minimum root and shoot length was found in seeds boiled in water for 15 minutes i.e. 0cm. Similarly, seeds without treatment and seeds boiled in water for 15 minutes showed the maximum fresh and dry weight (2.790gm & 0.488gm respectively) and seeds boiled in water for 15 minutes & seeds without treatment showed the minimum and dry weight (0.913gm & 0.289gm respectively) on the 9th day of observation. The results also showed that the seeds treated with ethrel (@0.3ml/lit) germinated (91%) with significant root & shoot length and fresh weight (4.55cm, 5.25cm and 2.537gm respectively).
EFFECT OF BIOFERTILIZER (AZOTOBACTER CHROOCOCUM) AT DIFFERENT NITROGEN LEVEL ON GROWTH AND YIELD OF CAULIFLOWER IN PALUNG, MAKWANPUR
Authors: Shrestha Sandesh , Devkota Durga , Paudel Bibechana
Published: October 2022

The main objective of this study is to evaluate the effect of nitrogen-biofertilizer Azotobacter chroococcum on the growth and yield of Brassica oleracea var botrytis; White Top under open field conditions. The study was done by planting 480 cauliflower seedlings distributed into six treatments; T1-control (without treatment), T2- 25% N and Azotobacter, T3- 100 N only, T4- 100 Nitrogen with Azotobacter, T5- 75% Nitrogen with Azotobacter and T6- 50% nitrogen with Azotobacter. The treatments were replicated four times. After 75 days and through cauliflower growth parameters; plant height, leaf number, leaf area, and yield parameter; curd height, curd diameter, curd weight, and yield were measured. The result depicted that the growth parameter of cauliflower increased its productivity of cauliflower. Plant height (20.69 cm), leaf number (13.5), and total leaf area (1035 cm2) were observed highest in treatment full dose of nitrogen along with Azotobacter inoculation. The shortest plant height (14.49 cm), lowest leaf number (10.00), and total leaf area (602 cm2) were observed in the control. The curd weight was found to be maximum in treatment full dose of nitrogen with inoculation (1.12 kg) whereas minimum curd weight was observed in control. Furthermore, the highest yield (43.08 Mt/ha) was obtained with treatment; the full dose of nitrogen along with biofertilizer inoculation followed by 75% nitrogen with biofertilizer and 100 full doses of nitrogen without biofertilizer had statistically similar yields showing the inoculation of biofertilizer can reduce the need of nitrogen through inorganic source by about 25%. Biofertilizer has been identified as an alternative to chemical fertilizer to increase soil fertility and crop production in sustainable farming. The use of biofertilizers is steadily increased in agriculture and offers an attractive way to replace chemical fertilizers, pesticides, and supplements.
A REVIEW ON EFFECTS OF HEAT STRESS ON MAIZE
Authors: Himani Chand , Barsha KC , Biddhya Pandey , Preeti Kayastha , Pawan Lamichhane , Janak Bhandari , Roka Magar Bimal , Prakash Baduwal , Ram Poudel Mukti
Published: October 2022

Maize is one of the most commonly grown cereal crops in the world and Nepal and remains a reliable source of staple food and food security. The term “Climate change” is mostly associated with the rise in air temperature of the earth simply signifies high temperature resulted due to anthropogenic greenhouse gas emissions. According to IPCC 6th Assessment report, if climate change is not opted to control then the yield projections of corn are driven to decrease with the multiplication of pests and weeds increasing costs for the production of major crops including maize. Before the climate-based impact gets vulnerable, a possible solution like breeding technologies and other management strategies need to be utilized for developing heat-tolerant varieties. Heat stress affects overall performance from germination to maturity but the effect on the reproductive stage results in the severe yield loss of the maize crop. This review provides a slight view of the effects of heat stress on maize productivity.