bluuebunny/crossref_metadata_2025 huggingface dataset:
Indicative Planning and France's Backstage Contribution to Eurozone Governance
Authors: Lovering Ian Alexander
Published: April 2023

This article examines the history of indicative planning in France to challenge conceptions of Eurozone governance. French planning is seen as a road not taken in Europe. Instead, the Eurozone is conceptualised through planning's antagonist – German ordoliberalism. Key features of this are rules‐based austerity and price stability pursued by an independent central bank. Scholars have, however, recognised that Eurozone governance exceeds ordoliberalism through a logic of integration oriented towards coordination rather than convergence and a governance rationality of performance management rather than legal enforcement. I analyse the historiography of indicative planning to argue that it provides a useful conceptual vantage point to understand these features of Eurozone governance. Highlighting the legacy of planning provides an alternative perspective on Eurozone politics. It shifts attention from the German‐led legal constraints imposed on national governments to how techniques of planning have suited French state desires for international coordination without supranational domination.
The acute effects of community violence on young children's regulatory, behavioral, and developmental outcomes in a low‐income urban sample in Brazil
Authors: McCoy Dana C. , Dormal Marta , Cuartas Jorge , Carreira dos Santos Angélica , Fink Günther , Brentani Alexandra
Published: April 2023

Background

Existing research on the impacts of adversity on young children's psychological well‐being has largely focused on household‐level risk factors using observational methods in high‐income countries. This study leverages natural variation in the timing and location of community homicides to estimate their acute effects on the regulatory, behavioral, and developmental outcomes of Brazilian 3‐year‐olds.

Methods

We compared the outcomes of children who were assessed soon after a recent neighborhood homicide to those of children from the same residential neighborhoods who had not recently experienced community violence. Our sample included 3,241 3‐year‐olds (Mage = 41.05 months; 53% female; 45% caregiver education less than middle school; 26% receiving a public assistance program) from seven neighborhoods in São Paulo, Brazil. Child outcome measures included parent reports of effortful control and behavior problems as well as direct assessments of children's developmental (cognitive, language, and motor) skills. Community homicides were measured using police records.

Results

Recent exposure to community homicides was associated with lower effortful control, higher behavior problems, and lower overall developmental performance for children (d = .05–.20 standard deviations; p = ns – <.001). Effects were consistent across subgroups based on sociodemographic characteristics and environmental supports, but generally largest when community violence exposure was geographically proximal (within 600 m of home) and recent (within 2 weeks prior to assessment).

Conclusions

Results highlight the pervasive effects that community violence can have on young children as well as the need to expand support to mitigate these effects and prevent inequities early in life.
Effects of preservation by ethanol on δ13C and δ15N of three tissues of the critically endangered European eel Anguilla anguilla
Authors: Boardman Rose M. , Pinder Adrian C. , Piper Adam T. , Gutmann Roberts Catherine , Wright Rosalind M. , Britton John Robert
Published: April 2023

The temporal effects of ethanol preservation on the δ13C and δ15N values of tissues excised from European eel Anguilla anguilla were assessed. Preservation significantly enriched 13C values of fin and mucus but not dorsal muscle. The 13C enrichment occurred in the initial 15 days of preservation and was independent of initial eel mass. Tissue preservation effects on δ15N values were negligible. These tissue‐specific isotopic shifts should be considered when ethanol‐preserved eel samples are used.
Emotional eating among adults with healthy weight, overweight and obesity: a systematic review and meta‐analysis
Authors: Vasileiou V. , Abbott S.
Published: April 2023

Background

Emotional eating (EE) is a disordered eating behaviour which may lead to overeating. It is not clear whether EE presents to an equal degree among adults, regardless of their body mass index (BMI) status. The aim of this study was to assess whether there is a difference in degree of EE between adults with healthy weight, overweight and obesity.

Methods

MEDLINE and APA PsycINFO databases were searched from inception up to January 2022 for studies that reported EE scores from validated questionnaires. The quality of all included studies was assessed using the AXIS tool. Meta‐analysis used random effects and standardised mean difference (SMD). Heterogeneity was investigated using I2 statistics and sensitivity analyses.

Results

A total of 11 studies with 7207 participants were included in the meta‐analysis. Degree of EE was greater in adults with a BMI above the healthy range, compared to adults with a healthy BMI (SMD 0.31, 95% CI 0.17 to 0.45; I2 = 85%). However, subgroup analysis found that degree of EE was greater only in adults with obesity (SMD 0.61, 95% CI 0.41 to 0.81; I2 = 62%), and there was no difference in degree of EE between adults with overweight and those with a healthy BMI.

Conclusions

Degree of EE is greater among adults living with obesity, compared to adults with a healthy BMI, indicating a need for behavioural support to support EE among people living with obesity seeking weight management. Future research should examine the long‐term effectiveness of interventions for EE.
Abstraction and analogy in AI
Authors: Mitchell Melanie
Published: April 2023

The abilities to form concepts and abstractions, and to make analogies, are key to human intelligence, but AI systems have a long way to go before they can match the abilities of humans in these areas. To develop machines that can abstract and analogize, researchers typically focus on idealized problem domains that are meant to capture the essence of human abstraction abilities without having to deal with the complexity of real‐world situations. This commentary describes why solving problems in these domains remains difficult for AI systems, and discusses how AI researches can make progress on imbuing machines with these essential abilities.
Undiversity, inequity, and exclusion in supply chains: The unintended fallout of economic sanctions and consumer boycotts
Authors: Shalpegin Timofey , Kumar Ajay , Browning Tyson R.
Published: April 2023

Economic sanctions and consumer boycotts are common tools to punish organizations for undesirable behavior and attempt to coerce them to change their actions. However, these tools occasionally spill over beyond the intended recipients and affect guiltless supply chain members, jeopardizing the principles of diversity, equity, and inclusion in supply chains. This study identifies four channels through which sanctions and boycotts propagate through supply chains. In particular, supply chain members can be affected by direct relationships with targeted organizations, disruptions in accessing foreign markets, inability to access technology, and logistics failures. Potential solutions include mapping supply chains, proactive cooperation, network analysis, and shortening supply chains. While the work provides a general framework for research and practitioners, it also identifies areas for further studies, such as the role of new technologies and the effect of sanctions and boycotts on supply chain sustainability.
How does information technology capabilities affect business sustainability? The roles of ambidextrous innovation and data‐driven culture
Authors: Lee Voon‐Hsien , Dwivedi Yogesh K. , Tan Garry Wei‐Han , Ooi Keng‐Boon , Wong Lai‐Wan
Published: April 2023

This research investigates explicitly how Information technology capability (ITC) can be tailored to achieve business sustainability via ambidextrous innovation in a turbulent environment. Moreover, the moderating factor of a data‐driven culture (DDC) is also being investigated. The research model was built on the theoretical foundations of the resource‐based view (RBV), dynamic capabilities view and existing IT capabilities literature. Through a close‐ended survey questionnaire from approximately 254 IT personnel in managerial positions working in the manufacturing industry, partial least squares‐structural equation modelling‐artificial neural network (PLS‐SEM‐ANN) is applied. Notably, the result indicated that ITC positively influences IT‐enabled dynamic capabilities (ITDC), which positively impacts ambidextrous innovations and helps manufacturing firms achieve business sustainability. Meanwhile, the moderating role of DDC between ITDC and exploitative innovation was also found. The results showed that ANN models A, B, C and D are consistent for both analysis. This study provides several novel additions to the literature on operations management and information systems (IS) researchers. IS researchers should focus on leveraging ITC to enable and support organisational capabilities rather than the direct effects of IT expenditures. Additionally, the importance of a DDC has seldom been explored together previously. Thus, this study fills gaps in existing knowledge, along with significant insights, specifically for future IT implementation. As for practical implications, this study provides corporate leaders and executives with insights about how to leverage their resources and customise their ITC in an unpredictable and volatile business environment.
Special care dentistry education during the COVID‐19 pandemic: The impact of online peer‐assisted learning
Authors: Mohd Suria Tun Yasmin Iffah , Omar Aminda Faizura , Wan Mokhtar Ilham , Rahman Aida Nur Ashikin Abdul , Kamaruddin Azwin Assilah , Ahmad Mas Suryalis
Published: April 2023

Objectives

This study aims to analyze the impact and students’ perceptions of online peer‐assisted learning (OPL), developed as an alternative and innovative approach to Special Care Dentistry (SCD) training during the COVID‐19 pandemic. Online peer‐assisted learning (OPL) is an alternative pedagogical approach that combines online education and peer‐assisted teaching.

Methods

The OPL session was conducted by two postgraduate students in SCD (as teachers), to final year undergraduate dental students (as learners) (n = 90), supervised by two specialists in SCD‐related areas (as supervisors). Vetted online pre‐ and post‐intervention quizzes were conducted before and after the session, respectively, followed by an online validated feedback survey of the students’ learning experiences. Meanwhile, a reflective session was conducted between the postgraduate students and supervisors to explore their perceptions of OPL. Quantitative data was analyzed via paired t‐test (significance level, P < .05). Qualitative data was analyzed via thematic analysis.

Results

Overall, 68 (response rate = 75.6%) and 81 (response rate = 90.0%) undergraduate students completed the quiz and feedback survey, respectively. There was a significant difference in total mean scores, and mean scores of 7 (out of 10) individual items on the quizzes. Most students offered positive reviews of multiple aspects of OPL. They acknowledged the benefit of OPL for its content and preparation process, technology utilized, and experts’ roles. Postgraduate students perceived that OPL encourages knowledge‐recall and utilization of technology‐based educational tools, while improving their teaching skills.

Conclusion

Students provided positive responses toward the implementation of OPL as an innovative approach to the teaching and learning of SCD during the COVID‐19 pandemic.
Federalism and development in Nigeria
Authors: Arowosegbe Jeremiah O.
Published: April 2023

The federal solution has been widely discussed in relation to political systems where the articulation of major cleavages, differences, and pluralities threatens political integration and stability. The relationship between conflict, development, and federalism, however, has been poorly accounted for in the literature on federalism. Existing theories about the utilitarian value of federalism thus face serious challenges, especially with respect to post‐colonial Africa. The relationship between conflict, economic development, and federalism in the African context needs to be carefully examined from the perspective of governance, as well as the impact they have on society‐state relations. This article discusses the impact of ethno‐linguistic, ethno‐regional, and ethno‐religious conflicts on economic development in Nigeria – informed by the inequalities, insecurity, and poverty prevalent in the country – and examines the relevance of the federal solution for mitigating such centrifugal pressures as well as other divisive and violent tendencies.
Risk factors of cytomegalovirus infection after pediatric liver transplantation and effectiveness of preemptive therapy
Authors: Chanburanavah Nopparak , Boonsathorn Sophida , Apiwattanakul Nopporn , Lertudomphonwanit Chatmanee , Getsuwan Songpon , Tanpowpong Pornthep , Treepongkaruna Suporn
Published: April 2023

Background

Cytomegalovirus (CMV) infection is the most common infection following pediatric liver transplantation (LT). Preemptive therapy (PET) is an approach to initiate antiviral treatment for asymptomatic early CMV viremia detected by surveillance testing. However, data on CMV infection after PET are scarce, and the optimal cut‐off remains controversial. This study aimed to evaluate the incidence, risk factors, and consequences of CMV infection in pediatric LT using 2 different viral load (VL) cut‐offs.

Methods

We retrospectively reviewed patients aged 0–18 years who underwent LT at Ramathibodi Hospital between March 2001 and August 2020. Demographic data, CMV infection, CMV treatment, and consequences of CMV infection were collected. CMV viremia was monitored by a quantitative nucleic acid amplification test. Clinical outcomes were compared after starting antiviral therapy at a low (>400 but <2000 IU/mL) and a high VL cut‐off (≥2000 IU/mL).

Results

A total of 126 patients were included. CMV infection was 71% (90/126), with an incidence rate of 5.5 per 1000 patient‐day. Higher tacrolimus and prednisolone dosages were associated with CMV infection with an adjusted hazard ratio of 1.2 (95%CI 1.0–1.4, p = .02) and 2.4 (95%CI 1.9–3.4, p < .001), respectively. The consequences of CMV infection did not differ significantly for the low and high CMV VL cut‐off groups.

Conclusion

CMV infection in LT recipients is common and is associated with higher tacrolimus and corticosteroid dosage. Additionally, using the CMV VL cut‐off at 2000 IU/mL to initiate antiviral therapy is practical and effective in preventing CMV disease.

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Identification of protein kinase A signalling molecules in renal collecting ducts
Authors: Ando Fumiaki , Hara Yu , Uchida Shinichi
Published: April 2023

Body water homeostasis is maintained by the correct balance between water intake and water loss through urine, faeces, sweat and breath. It is known that elevated circulating levels of the antidiuretic hormone vasopressin decrease urine volume to prevent excessive water loss from the body. Vasopressin/cAMP/protein kinase A (PKA) signalling is the canonical pathway in renal collecting ducts for phosphorylating aquaporin‐2 (AQP2) water channels, which leads to the reabsorption of water from urine via AQP2. Although recent omics data have verified various downstream targets of PKA, crucial regulators that mediate PKA‐induced AQP2 phosphorylation remain unknown, mainly because vasopressin is usually used to activate PKA as a positive control. Vasopressin is extremely potent and phosphorylates various PKA substrates non‐specifically, making it difficult to narrow down the candidate mediators responsible for AQP2 phosphorylation. The intracellular localization of PKA is tightly regulated by its scaffold proteins, also known as A‐kinase anchoring proteins (AKAPs). Furthermore, each AKAP has a target domain that determines its intracellular localization, enabling the creation of a local PKA signalling network. Although vasopressin activates most PKAs independently of their intracellular localization, some chemical compounds preferentially act on PKAs localized on AQP2‐containing vesicles while simultaneously phosphorylating AQP2 and its surrounding PKA substrates. Immunoprecipitation with antibodies against phosphorylated PKA substrates followed by mass spectrometry analysis revealed that the PKA substrate in proximity to AQP2 was lipopolysaccharide‐responsive and beige‐like anchor (LRBA). Furthermore, Lrba knockout studies revealed that LRBA was required for vasopressin‐induced AQP2 phosphorylation.

image
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction
Authors: Bowin Carl-Fredrik , Kozielewicz Pawel , Grätz Lukas , Kowalski-Jahn Maria , Schihada Hannes , Schulte Gunnar
Published: April 2023

Frizzleds (FZDs) are G protein–coupled receptors (GPCRs) that bind to WNT family ligands. FZDs signal through multiple effector proteins, including Dishevelled (DVL), which acts as a hub for several downstream signaling pathways. To understand how WNT binding to FZD stimulates intracellular signaling and influences downstream pathway selectivity, we investigated the dynamic changes in the FZD
5
-DVL2 interaction elicited by WNT-3A and WNT-5A. Ligand-induced changes in bioluminescence resonance energy transfer (BRET) between FZD
5
and DVL2 or the isolated FZD-binding DEP domain of DVL2 revealed a composite response consisting of both DVL2 recruitment and conformational dynamics in the FZD
5
-DVL2 complex. The combination of different BRET paradigms enabled us to identify ligand-dependent conformational dynamics in the FZD
5
-DVL2 complex and distinguish them from ligand-induced recruitment of DVL2 or DEP to FZD
5
. The observed agonist-induced conformational changes at the receptor-transducer interface suggest that extracellular agonist and intracellular transducers cooperate through transmembrane allosteric interaction with FZDs in a ternary complex reminiscent of that of classical GPCRs.
FtsE, the Nucleotide Binding Domain of the ABC Transporter Homolog FtsEX, Regulates Septal PG Synthesis in
E. coli
Authors: Mallik Sunanda , Dodia Hiren , Ghosh Arup , Srinivasan Ramanujam , Good Liam , Raghav Sunil Kumar , Beuria Tushar Kant
Published: April 2023

The peptidoglycan (PG) layer is an essential component of the
E.coli
envelope that is required to maintain cellular shape and integrity. Thus, coordinating PG synthesis and hydrolysis at the mid-cell (septal PG) is crucial during bacterial division.
Approaches to improving patient safety in integrated care: a scoping review
Authors: Lalani Mirza , Wytrykowski Sarah , Hogan Helen
Published: April 2023

Objectives

This scoping review aimed to establish the approaches employed to improving patient safety in integrated care for community-dwelling adults with long-term conditions.

Design

Scoping review.

Setting

All care settings.

Search strategy

Systematic searches of seven academic and grey literature databases for studies published between 2000 and 2021. At the full-text review stage both the first and second reviewer (SW) independently assessed full texts against the eligibility criteria and any discrepancies were discussed.

Results

Overall, 24 studies were included in the review. Two key priorities for safety across care boundaries for adults with long-term conditions were falls and medication safety. Approaches for these priorities were implemented at different levels of an integrated care system. At the micro-level, approaches involved care primarily in the home setting provided by multi-disciplinary teams. At the meso-level, the focus was on planning and designing approaches at the managerial/organisational level to deliver multi-disciplinary care. At the macro-level, system-wide approaches included integrated care records, training and education and the development of care pathways involving multiple organisations. Across the included studies, evaluation of these approaches was undertaken using a wide range of process and outcome measures to capture patient harm and contributory factors associated with falls and medication safety.

Conclusions

For integrated care initiatives to fulfil their promise of improving care for adults with long-term conditions, approaches to improve patient safety need to be instituted across the system, at all levels to support the structural and relational aspects of integrated care as well as specific risk-related safety improvements.
Association between low blood selenium concentrations and poor hand grip strength in United States adults participating in NHANES (2011–2014)
Authors: Pei Jingjing , Yan Lailai , Wu Yuwan , Zhang Xi , Jia Huan , Li Huajun
Published: April 2023

The trace element selenium, which is found in selenoproteins, plays an antioxidant role in preventing muscle tissue injury. A positive association between selenium concentrations and hand grip strength has been reported in older adults; however, the evidence of this association is scarce in general adults. In this study, we aimed to evaluate the association between blood selenium concentrations and low hand grip strength using the data from the National Health and Nutrition Examination Survey 2011–2012 and 2013–2014 in the United States (US). Logistic regression was used to calculate the odds ratio (OR) of low hand grip strength, with blood selenium level adjusted for potential confounders. Among 8158 adults (women: 51.59%) with a mean age of 47 (range: 18–80) years, women and non-Hispanic Blacks tended to have low blood selenium concentrations. Notably, participants with high blood selenium concentrations (range, 178.1–192.5 µg/L) were more likely to have a low risk of low hand grip strength after adjusting for the potential covariates (OR: 0.60, 95% confidence interval (CI): 0.38–0.95) than those with low blood selenium concentrations. After excluding participants with chronic diseases, high blood selenium concentrations were found to be associated with a low risk of low hand grip strength (OR: 0.30, 95% CI: 0.14–0.65). A J-shaped relationship was found between selenium concentrations and low hand grip strength ( P for nonlinear trend <0.0001). Subgroup analyses revealed a significantly consistent relationship among women, non-Hispanic Whites and others, and individuals with overweight or obesity ( P < 0.05). Our study suggests that blood selenium concentrations are inversely associated with hand grip strength in general US adults. However, further prospective studies are required to confirm the causality between selenium concentrations and hand grip strength.
Measurement of total and partial cross sections of the $$^{90}$$Zr(p,$$\gamma $$)$$^{91}$$Nb reaction with in-beam $$\gamma $$-ray spectroscopy
Authors: Erbacher Philipp , Heftrich Tanja , Endres Anne , Glorius Jan , Netterdon Lars , Just David , Göbel Kathrin , Krtička Milan , Reifarth René , Sonnabend Kerstin , Thomas Benedikt , Weigand Mario , Zilges Andreas
Published: April 2023

The origin of many p-nuclei remains an unsolved problem in nuclear astrophysics. While photo-dissociation reactions in the $$\gamma $$
γ
-process can explain the production of many p-nuclei, some, notably $$^{92,94}$$

92
,
94

Mo and $$^{96,98}$$

96
,
98

Ru are underproduced in network calculations. The $$^{90}$$

90

Zr(p,$$\gamma $$
γ
)$$^{91}$$

91

Nb reaction is part of a possible (p,$$\gamma $$
γ
) reaction chain for the production of the p-nucleus $$^{92}$$

92

Mo. Available data show a large disagreement between the different reported cross sections measurements for the $$^{90}$$

90

Zr(p,$$\gamma $$
γ
)$$^{91}$$

91

Nb reaction. We measured proton capture cross sections with an enriched $$^{90}$$

90

Zr target using in-beam $$\gamma $$
γ
-ray spectroscopy for proton energies between 2.75 MeV and 5.1 MeV. The emitted $$\gamma $$
γ
-rays were detected using the HORUS (High efficiency Observatory for $$\gamma $$
γ
-Ray Unique Spectroscopy) detector array at the University of Cologne, Germany. To account for the possible contribution of the $$^{91}$$

91

Zr(p,n) reaction, an enriched $$^{91}$$

91

Zr was irradiated. We measured production cross sections for the ground and isomeric state of $$^{91}$$

91

Nb as well as partial cross section for up to ten high-energy primary transitions. The results are in good agreement with a former in-beam $$\gamma $$
γ
-ray spectroscopy measurement by Laird et al.. We provide a possible explanation for the discrepancies between our data and other available measurements.
The Hubble constant from galaxy cluster scaling-relation and SNe Ia observations: a consistency test
Authors: Bora Kamal , Holanda R. F. L.
Published: April 2023

In this paper, we propose a self-consistent test for a Hubble constant estimate using galaxy cluster and type Ia supernovae (SNe Ia) observations. The approach consists, in a first step, of obtaining the observational value of the galaxy cluster scaling-relation $$Y_{SZE}D_{A}^{2}/C_{XSZ}Y_X = C $$

Y

SZE

D

A

2

/

C

XSZ

Y
X

=
C

by combining the X-Ray and SZ observations of galaxy clusters at low redshifts ($$z < 0.1$$

z
<
0.1

) from the first Planck mission all-sky data set ($$0.044 \le z \le 0.444$$

0.044
≤
z
≤
0.444

), along with SNe Ia observations and making use of the cosmic distance duality relation validity. Then, by considering a flat $$\Lambda $$
Λ
CDM model for $$D_A$$

D
A

, the constant C from the first step and the Planck prior on $$\Omega _M$$

Ω
M

parameter, we obtain $$H_0$$

H
0

by using the galaxy cluster data with $$z>0.1$$

z
>
0.1

. As a result, we obtain $${ H_0=73.014^{+7.435}_{-6.688}}$$

H
0

=
73
.

014

-
6.688

+
7.435

km/s/Mpc, in full agreement with the latest results from HST + SH0ES team. We also compare our method with that one where the C parameter is obtained from hydrodynamical simulations of massive galaxy clusters.
Hopf Structure for the q-Lévy-Meixner Oscillator Algebra
Authors: Riahi Anis , Rebei Habib , Ettaieb Amine , Alhussain Ziyad Ali , Elmonser Hedi Ben
Published: April 2023

The main purpose of this paper is to investigate a generalized oscillator algebra, naturally associated with the [Formula: see text]-Lévy-Meixner polynomials. We solve the problem of the Hopf algebraic structure for the [Formula: see text]-deformed Lévy-Meixner oscillator algebra based on the one-parameter deformation of canonical commutation relations.
Exploring the Limits of Controlled Markovian Quantum Dynamics with Thermal Resources
Authors: vom Ende Frederik , Malvetti Emanuel , Dirr Gunther , Schulte-Herbrüggen Thomas
Published: April 2023

Our aim is twofold: First, we rigorously analyse the generators of quantum-dynamical semigroups of thermodynamic processes. We characterise a wide class of gksl-generators for quantum maps within thermal operations and argue that every infinitesimal generator of (a one-parameter semigroup of) Markovian thermal operations belongs to this class. We completely classify and visualise them and their non-Markovian counterparts for the case of a single qubit. Second, we use this description in the framework of bilinear control systems to characterise reachable sets of coherently controllable quantum systems with switchable coupling to a thermal bath. The core problem reduces to studying a hybrid control system (“toy model”) on the standard simplex allowing for two types of evolution: (i) instantaneous permutations and (ii) a one-parameter semigroup of [Formula: see text]-stochastic maps. We generalise upper bounds of the reachable set of this toy model invoking new results on thermomajorisation. Using tools of control theory we fully characterise these reachable sets as well as the set of stabilisable states as exemplified by exact results in qutrit systems.
Atrio-Esophageal Fistula: A Rare Entity Complicating a Common Procedure
Authors: Sanoja I. A.
Published: April 2023

A 66-year-old female with a history of radiofrequency ablation for atrial fibrillation presented with hematemesis and fever. A CT chest revealed an atrio-esophageal fistula (AEF) and a CT head showed bilateral septic emboli. Blood cultures were positive for Streptococcus sanguinis. She underwent primary repair of the atrial defect on cardiopulmonary bypass where a large atrial vegetation was retrieved, followed by a right thoracotomy with the closure of the esophageal defect the next day. She was discharged to a rehabilitation facility after 18 days of hospital stay with a 6 weeks antibiotics plan. The incidence of AEF following ablation procedures has been estimated at 0.01 to 0.04%, and the pathogenesis is linked to direct tissue and vagus nerve injury. The most common clinical findings are fever and neurologic deficits. CT chest is the best diagnostic modality. CT head might demonstrate embolic phenomena and TTE can show vegetation. Early surgical intervention, even in an unstable patient, is paramount for survival.
MAGDM Model Using the Exponential Similarity Measure of Neutrosophic Confidence Cubic Sets in a Single-Valued Neutrosophic Multivalued Circumstance
Authors: Ye Jun , Zhang Zhenhan , Yong Rui , Du Shigui
Published: April 2023

Probability estimation of small sample data is a key tool to ensure the probability that sample data fall within the confidence interval at a certain confidence level and probability distribution, which shows its advantages in practical engineering applications. Then, regarding a group decision-making (GDM) problem in the situation of indeterminacy and inconsistency, several experts/decision makers will assign several true, false, and indeterminate fuzzy values to the evaluation values of each alternative over different attributes, and then form a single-valued neutrosophic multivalued set (SvNMVS) as their assessed information. To ensure some confidence level of the evaluation values in the circumstance of SvNMVSs and GDM reliability, this paper aims to propose a conversion technique from SvNMVS to a neutrosophic confidence cubic set (NCCS) and a GDM model using the exponential similarity measure of NCCSs in the circumstance of SvNMVSs. First, we give the definition of NCCS, which is transformed from SvNMVS in terms of average values and confidence intervals of true, false, and indeterminate fuzzy sequences subject to the conditions of the normal distribution and confidence levels. Second, we present the exponential similarity measure of NCCSs and the weighted exponential similarity measure of NCCSs and their characteristics. Third, a GDM model is developed by using the weighted exponential similarity measure of NCCSs in the circumstance of SvNMVSs. Fourth, the developed GDM model is applied to a choice case of landslide treatment schemes in the circumstance of SvNMVSs to reveal its usability and suitability in actual GDM problems. Compared with the existing GDM models, the developed GDM model indicates its superiorities in decision flexibility and credibility/reliability subject to 90%, 95%, and 99% confidence levels.
Experimental Study for the Effects of Different Factors on the Sand-Carrying Capacity of Slickwater
Authors: Peng Huan , Li Wenzhe , Liu Juncheng , Peng Junliang , Han Huifen , Liu Jiayi , Liu Dan , Yang Zhifan
Published: April 2023

With the continuous exploration and development of unconventional oil and gas reservoirs, volume fracturing technology becomes one of the necessary measures for developing shale gas and tight sandstone gas reservoirs effectively. Volume fracturing technology usually uses slickwater and drag-reducing agent as the core of the fracturing system. The composition of the fracturing system is the main factor determining its performance. Polyacrylamide has many amide groups in its main chain, high activity, and controllable performance, often in solid powder and liquid emulsion states. Furthermore, polyacrylamide which is the water-soluble drag-reducing agent is most widely used in applying current shale gas slickwater fracturing operations. Due to the low viscosity and poor sand-carrying capacity of slickwater, proppant easily settles at the bottom of hydraulic fractures. This phenomenon influences the stimulation effect of volume fracturing. Therefore, the law of sand carrying and placement of proppant in hydraulic fractures in volume fracturing plays an essential role in determining the success of the stimulation effect of volume fracturing. Through the visualization device of proppant transport in the fracture, the settlement of proppant in the fracture was studied experimentally. And through experimental equipment, the effects of different operation pumping rates, liquid viscosity, proppant type, and proppant pumping schedule on the stimulation effect were studied. The experimental results can provide strong support for volume fracturing into well material optimization and operation parameter optimization for unconventional oil and gas reservoirs.
Supplementary Table S2 from Identification of Kinase Inhibitor Targets in the Lung Cancer Microenvironment by Chemical and Phosphoproteomics
Authors: Gridling Manuela , Ficarro Scott B. , Breitwieser Florian P. , Song Lanxi , Parapatics Katja , Colinge Jacques , Haura Eric B. , Marto Jarrod A. , Superti-Furga Giulio , Bennett Keiryn L. , Rix Uwe
Published: April 2023

Table S2. Mass spectrometry data of chemical proteomics experiments with c-dasatinib and c-sunitinib in primary NSCLC tissue samples.
Supplementary Fig. 7 from Sunitinib Dose Escalation Overcomes Transient Resistance in Clear Cell Renal Cell Carcinoma and Is Associated with Epigenetic Modifications
Authors: Adelaiye Remi , Ciamporcero Eric , Miles Kiersten Marie , Sotomayor Paula , Bard Jonathan , Tsompana Maria , Conroy Dylan , Shen Li , Ramakrishnan Swathi , Ku Sheng-Yu , Orillion Ashley , Prey Joshua , Fetterly Gerald , Buck Michael , Chintala Sreenivasulu , Bjarnason Georg A. , Pili Roberto
Published: April 2023

Supplementary Fig. 7. EZH2 and E-cadherin mRNA expression in 786-0shRNA scramble, 786-0shEZH2 (clone a and d), and 786-0 treated with GSK126
Supplementary Figure 1 from An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models
Authors: Scales Suzie J. , Gupta Nidhi , Pacheco Glenn , Firestein Ron , French Dorothy M. , Koeppen Hartmut , Rangell Linda , Barry-Hamilton Vivian , Luis Elizabeth , Chuh Josefa , Zhang Yin , Ingle Gladys S. , Fourie-O'Donohue Aimee , Kozak Katherine R. , Ross Sarajane , Dennis Mark S. , Spencer Susan D.
Published: April 2023

Supplementary Figure 1: IHC validation of anti-mesothelin antibody 19C3.
Supplementary Figures 1-7 from Tumor-Penetrating iRGD Peptide Inhibits Metastasis
Authors: Sugahara Kazuki N. , Braun Gary B. , de Mendoza Tatiana Hurtado , Kotamraju Venkata Ramana , French Randall P. , Lowy Andrew M. , Teesalu Tambet , Ruoslahti Erkki
Published: April 2023

Supplementary Figures 1-7. Supplemental Figure 1: Metastatic burden and primary tumor weight after long term in vivo peptide treatment Supplemental Figure 2: In vitro and in vivo targeting of pancreatic tumor cells by iRGD and iNGR Supplemental Figure 3: Inhibition of tumor cell attachment to vitronectin by RGD peptides Supplemental Figure 4: In vitro cell toxicity of CendR peptides Supplemental Figure 5: Chemorepulsion assay design Supplemental Figure 6: Inhibition of NRP-1-dependent GFP-PC-3 cell attachment to fibronectin Supplemental Figure 7: Effects of CendR peptides on tumor cell attachment to collagen type-1 Legends of Supplementary Movies SM1 through SM5
Supplementary Figures S1-S7 and Table from The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR Inhibitor
Authors: Nakanishi Yoshito , Akiyama Nukinori , Tsukaguchi Toshiyuki , Fujii Toshihiko , Sakata Kiyoaki , Sase Hitoshi , Isobe Takehito , Morikami Kenji , Shindoh Hidetoshi , Mio Toshiyuki , Ebiike Hirosato , Taka Naoki , Aoki Yuko , Ishii Nobuya
Published: April 2023

Supplementary Figures S1-S7 and Table. S1: Determination of the binding mode of the FGFR inhibitor CH5183284/Debio 1347. S2: Effects of CH5183284/Debio 1347 and cediranib on in vitro VEGF-induced tube formation. S3: Kinase activity of FGFR2 WT, V564F, V564I, and V564L mutants. S4: Inhibition of cellular pY-FGFR2 WT, pY-FGFR2 V564F, pY-FGFR2 V564I, and pY-FGFR2 V564L. S5: Susceptibility of CH5183284/Debio 1347 against gatekeeper mutants of FGFR2. S6: Antitumor activity of CH5183284/Debio 1347 and AZD4547 in Ba/F3 TEL-FGFR2 WT-driven mouse model. S7: Kinase inhibition assay of FGFR2 WT or FGFR2 N549H mutant. Supplementary Table S1: Crystallographic data collection and refinement statistics for FGFR1 in complex with CH5183284/Debio 1347.
Supplementary Figure 5 from Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus
Authors: Huynh Hung , Hao Huai-Xiang , Chan Stephen L. , Chen David , Ong Richard , Soo Khee Chee , Pochanard Panisa , Yang David , Ruddy David , Liu Manway , Derti Adnan , Balak Marissa N. , Palmer Michael R. , Wang Yan , Lee Benjamin H. , Sellami Dalila , Zhu Andrew X. , Schlegel Robert , Huang Alan
Published: April 2023

Model of mTOR activation and everolimus sensitivity caused by TSC2 loss.
Figure S1 from HAb18G/CD147 Promotes Radioresistance in Hepatocellular Carcinoma Cells: A Potential Role for Integrin β1 Signaling
Authors: Wu Jiao , Li Yong , Dang Ya-Zheng , Gao Hong-Xiang , Jiang Jian-Li , Chen Zhi-Nan
Published: April 2023

Fused PET-CT images of the mice bearing irradiated 7721-GFP or K7721-GFP cells. PET showed an increased 18F-FDG uptake in the irradiated 7721-GFP-bearing mouse. L=liver, U=urinary bladder.
Supplementary Figure S7 from Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer
Authors: Willuda Jörg , Linden Lars , Lerchen Hans-Georg , Kopitz Charlotte , Stelte-Ludwig Beatrix , Pena Carol , Lange Claudia , Golfier Sven , Kneip Christoph , Carrigan Patricia E. , Mclean Kirk , Schuhmacher Joachim , von Ahsen Oliver , Müller Jörg , Dittmer Frank , Beier Rudolf , El Sheikh Sherif , Tebbe Jan , Leder Gabriele , Apeler Heiner , Jautelat Rolf , Ziegelbauer Karl , Kreft Bertolt
Published: April 2023

Mean relative body weights of NCI-H292 human NSCLC tumor-bearing mice treated with vehicle, C4.4A-ADC, cisplatin, or combination of cisplatin and C4.4A-ADC.
Supplementary Figure S11 from Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer
Authors: Willuda Jörg , Linden Lars , Lerchen Hans-Georg , Kopitz Charlotte , Stelte-Ludwig Beatrix , Pena Carol , Lange Claudia , Golfier Sven , Kneip Christoph , Carrigan Patricia E. , Mclean Kirk , Schuhmacher Joachim , von Ahsen Oliver , Müller Jörg , Dittmer Frank , Beier Rudolf , El Sheikh Sherif , Tebbe Jan , Leder Gabriele , Apeler Heiner , Jautelat Rolf , Ziegelbauer Karl , Kreft Bertolt
Published: April 2023

Anti-tumor efficacy of C4.4A-ADC in NSCLC PDX models in mice.
Supplementary Figure S1 from Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer
Authors: Willuda Jörg , Linden Lars , Lerchen Hans-Georg , Kopitz Charlotte , Stelte-Ludwig Beatrix , Pena Carol , Lange Claudia , Golfier Sven , Kneip Christoph , Carrigan Patricia E. , Mclean Kirk , Schuhmacher Joachim , von Ahsen Oliver , Müller Jörg , Dittmer Frank , Beier Rudolf , El Sheikh Sherif , Tebbe Jan , Leder Gabriele , Apeler Heiner , Jautelat Rolf , Ziegelbauer Karl , Kreft Bertolt
Published: April 2023

Synthesis of C4.4A-ADC (A), Active metabolites resulting from intracellular degradation of C4.4A-ADC (B), Activity of the C4.4A-ADC metabolites (C), Range of drug-to-antibody ratio (D), and Purity and aggregate content of the ADC (E).
Supplementary Figures S1-S2 from Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer
Authors: Takehara Kiyoto , Tazawa Hiroshi , Okada Naohiro , Hashimoto Yuuri , Kikuchi Satoru , Kuroda Shinji , Kishimoto Hiroyuki , Shirakawa Yasuhiro , Narii Nobuhiro , Mizuguchi Hiroyuki , Urata Yasuo , Kagawa Shunsuke , Fujiwara Toshiyoshi
Published: April 2023

Supplementary Fig. S1: Schematic diagrams of the structures of replication-deficient and conditionally; Supplementary Fig. S2: The GFP fluorescence intensity of metastatic lymph nodes in HCT116-GFP-bearing mice after treatment with TelomKiller and laser irradiation. replicating adenovirus vectors; Supplementary Fig. S2: The GFP fluorescence intensity of metastatic lymph nodes in HCT116-GFP-bearing mice after treatment with TelomKiller and laser irradiation.
Supplementary Figure 6 from Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma
Authors: Seystahl Katharina , Papachristodoulou Alexandros , Burghardt Isabel , Schneider Hannah , Hasenbach Kathy , Janicot Michel , Roth Patrick , Weller Michael
Published: April 2023

TGF-β3 gene silencing does not affect TGF-β1 and TGF-β2 protein levels
Supplementary Figure 5 from Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma
Authors: Seystahl Katharina , Papachristodoulou Alexandros , Burghardt Isabel , Schneider Hannah , Hasenbach Kathy , Janicot Michel , Roth Patrick , Weller Michael
Published: April 2023

TGF-β3-targeted oligonucleotides: effects on viability and proliferation
Supplementary Materials and Methods. Supplementary Figure 1. from 7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action
Authors: Perlíková Pavla , Rylová Gabriela , Nauš Petr , Elbert Tomáš , Tloušťová Eva , Bourderioux Aurelie , Slavětínská Lenka Poštová , Motyka Kamil , Doležal Dalibor , Znojek Pawel , Nová Alice , Harvanová Monika , Džubák Petr , Šiller Michal , Hlaváč Jan , Hajdúch Marián , Hocek Michal
Published: April 2023

Supplementary Materials and Methods. Figure S1: MALDI-TOF spectrum of the single-stranded oligonucleotide products of primer extension experiment with human DNA polymerase γ, AB61-TP, primer Prim248 and template (bio)-OligoAterm.
Supplementary Figure 1 from Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation
Authors: Ang Joo Ern , Pandher Rupinder , Ang Joo Chew , Asad Yasmin J. , Henley Alan T. , Valenti Melanie , Box Gary , de Haven Brandon Alexis , Baird Richard D. , Friedman Lori , Derynck Mika , Vanhaesebroeck Bart , Eccles Suzanne A. , Kaye Stan B. , Workman Paul , de Bono Johann S. , Raynaud Florence I.
Published: April 2023

Heat map of changes (relative to vehicle control) in candidate plasma and tumor metabolite biomarkers at 8 hours post-dosing of mice bearing U87MG xenografts with pictilisib 75mg/kg or buparlisib 60mg/kg (a, acyl; aa, acyl-acyl; ae, acyl-alkyl; Cx:y, where x is the number of carbons in the fatty acid side chain; y is the number of double bonds in the fatty acid side chain; AC, acylcarnitine; DC, decarboxyl; M, methyl; OH, hydroxyl; PC, phosphatidylcholine)
Supplementary Figure S3 from Synergy between Androgen Receptor Antagonism and Inhibition of mTOR and HER2 in Breast Cancer
Authors: Gordon Michael A. , D'Amato Nicholas C. , Gu Haihua , Babbs Beatrice , Wulfkuhle Julia , Petricoin Emanuel F. , Gallagher Isela , Dong Ting , Torkko Kathleen , Liu Bolin , Elias Anthony , Richer Jennifer K.
Published: April 2023

RPPA heatmap all significant proteins by ANOVA
Supplemental Figure 6 from Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors
Authors: Goglia Alexander G. , Delsite Robert , Luz Antonio N. , Shahbazian David , Salem Ahmed F. , Sundaram Ranjini K. , Chiaravalli Jeanne , Hendrikx Petrus J. , Wilshire Jennifer A. , Jasin Maria , Kluger Harriet M. , Glickman J. Fraser , Powell Simon N. , Bindra Ranjit S.
Published: April 2023

Results for each of the 16 identified hits in the GFP-based DSB repair assay panel.
Supplementary Table 1 from Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer
Authors: Choudhary Alka , Zachek Brittany , Lera Robert F. , Zasadil Lauren M. , Lasek Amber , Denu Ryan A. , Kim Hyunjung , Kanugh Craig , Laffin Jennifer J. , Harter Josephine M. , Wisinski Kari B. , Saha Sandeep , Weaver Beth A. , Burkard Mark E.
Published: April 2023

This file contains Supplementary Table 1 and provides hazard ratios for recurrence free survival and overall survival for polyploidy and clinical variables using a Cox proportional hazard model.
Supplementary Figures S1 through S4 from Optimizing the Sequence of Anti-EGFR–Targeted Therapy in EGFR-Mutant Lung Cancer
Authors: Meador Catherine B. , Jin Hailing , de Stanchina Elisa , Nebhan Caroline A. , Pirazzoli Valentina , Wang Lu , Lu Pengcheng , Vuong Huy , Hutchinson Katherine E. , Jia Peilin , Chen Xi , Eisenberg Rosana , Ladanyi Marc , Politi Katerina , Zhao Zhongming , Lovly Christine M. , Cross Darren A.E. , Pao William
Published: April 2023

Fig. S1: Schematic of derivation 'lineages' for drug-sensitive and -resistant cell lines used in this study Fig. S2: Characterization of T790M+ cell lines Fig. S3: Characterization of A+C-resistant cell lines Fig. S4: Characterization of AZD9291-resistant cell lines
Figure S1 from Immune Effector Functions of Human IgG2 Antibodies against EGFR
Authors: Rösner Thies , Kahle Steffen , Montenegro Francesca , Matlung Hanke L. , Jansen J.H. Marco , Evers Mitchell , Beurskens Frank , Leusen Jeanette H.W. , van den Berg Timo K. , Valerius Thomas
Published: April 2023

The Figure S1 shows: A) Maximal EGFR binding of different EGFR antibodies B) Complement factor binding and deposition by combinations of EGFR IgG1/IgG1, IgG1/IgG2 and IgG2/IgG2 antibodies C) EGFR expression of A431 ctrl and A431 CD47 Ko cells D) Target antigen binding and growth inhibition induced by different Matuzumab variants
Figure S5 from Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma
Authors: Kizilbash Sani H. , Gupta Shiv K. , Chang Kenneth , Kawashima Ryo , Parrish Karen E. , Carlson Brett L. , Bakken Katrina K. , Mladek Ann C. , Schroeder Mark A. , Decker Paul A. , Kitange Gaspar J. , Shen Yuqiao , Feng Ying , Protter Andrew A. , Elmquist William F. , Sarkaria Jann N.
Published: April 2023

TAL mediated potentiation of TMZ efficacy in GBM12 flank xenografts
Figure S1A,B from Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts
Authors: Noto Fallon K. , Adjan-Steffey Valeriya , Tong Min , Ravichandran Kameswaran , Zhang Wei , Arey Angela , McClain Christopher B. , Ostertag Eric , Mazhar Sahar , Sangodkar Jaya , DiFeo Analisa , Crawford Jack , Narla Goutham , Jamling Tseten Y.
Published: April 2023

Karyotype analysis for Spermatogonia at passage 16, before transfection with XTNs demonstrating a normal male 40, XY karyotype.
Supplementary Methods and Tables S1-S3 from Phage Display-Derived Peptide-Based Dual-Modality Imaging Probe for Bladder Cancer Diagnosis and Resection Postinstillation: A Preclinical Study
Authors: Peng Li , Shang Wenting , Guo Pengyu , He Kunshan , Wang Hongzhi , Han Ziyu , Jiang Hongmei , Tian Jie , Wang Kun , Xu Wanhai
Published: April 2023

Table S1. Enrichment of phages for each round of selection from the phage display peptide library. Table S2. Patient characteristics and histopathological diagnosis. Table S3. Comparison of PLSWT7-DMI-based NIR-imaging analysis with histopathological diagnosis.
Figure S1 from Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma
Authors: Kizilbash Sani H. , Gupta Shiv K. , Chang Kenneth , Kawashima Ryo , Parrish Karen E. , Carlson Brett L. , Bakken Katrina K. , Mladek Ann C. , Schroeder Mark A. , Decker Paul A. , Kitange Gaspar J. , Shen Yuqiao , Feng Ying , Protter Andrew A. , Elmquist William F. , Sarkaria Jann N.
Published: April 2023

Evaluation of sensitizing effects of TAL in GBM cell lines