bluuebunny/crossref_metadata_2025 huggingface dataset:
Motion Panoramas
Authors: Bartoli Adrien , Dalal Navneet , Horaud Radu
Published: November 2004

In this paper we describe a method for analysing video sequences and for representing them as mosaics or panoramas. Previous work on video mosaicking essentially concentrated on static scenes. We generalize these approaches to the case of a rotating camera observing both static and moving objects where the static portions of the scene are not necessarily dominant, as it has been often hypothesized in the past. We start by describing a robust technique for accurately aligning a large number of video frames under unknown camera rotations and camera settings. The alignment technique combines a feature‐based method (initialization and refinement) with rough motion segmentation followed by a colour‐based direct method (final adjustment). This precise frame‐to‐frame alignment allows the dynamic building of a background representation as well as an efficient segmentation of each image such that moving regions of arbitrary shape and size are aligned with the static background. Thus a motion panorama visualizes both dynamic and static scene elements in a geometrically consistent way. Extensive experiments applied to archived videos of track‐and‐field events validate the approach. Copyright © 2004 John Wiley & Sons, Ltd.
A comparison of four stent designs on arterial injury, cellular proliferation, neointima formation, and arterial dimensions in an experimental porcine model
Authors: Taylor Allen J. , Gorman Patrick D. , Kenwood Bruce , Hudak Craig , Tashko Gerti , Virmani Renu
Published: November 2004

The stent‐artery interactions of different stent designs have implications for their clinical effects. We studied four different stent designs to compare their effects on arterial injury, cellular proliferation, neointima formation, and arterial dimensions. Eighteen nonatherosclerotic miniswine underwent random placement of 52 coronary stents (3.0 mm), including self‐expanding nitinol stents (no postdilation; Radius, n = 13) and balloon‐expandable stents (8 atm × 45 sec; Palmaz‐Schatz, n = 13; BX, n = 12; and Multilink, n = 14). Cellular proliferation was determined by S‐phase labeling with BrdU at 7, 14, and 28 days. Proliferation, injury scores, and arterial morphometry were blindly evaluated. All four stent designs had similar injury scores, cellular proliferation indexes (neointimal and medial), and adventitial areas. Nitinol stents resulted in a twofold increase in neointimal area and thickness in 28‐day vessels (P = 0.002). However, lumen area was similar for all stent designs because of an offsetting expansion in vessel area in nitinol stents (20% greater than balloon‐expandable stents) occurring between 7 and 14 days after stent deployment (P = 0.03). Reduced neointimal cell density in nitinol stents (20% less than balloon‐expandable stents, P = 0.012) suggests that extracellular matrix expansion accounts for the larger neointima in nitinol stents. Self‐expansion of nitinol stents within normal porcine arteries results in a similar degree of arterial injury compared to balloon‐expandable stent designs. Progressive enlargement of nitinol stents between 7 and 14 days after deployment is associated with the development of a larger, matrix‐rich neointima, with a preserved lumen area. Cathet Cardiovasc Intervent 2001;53:420–425. Published 2001 Wiley‐Liss, Inc.
Cutting balloon angioplasty for treatment of calcified coronary lesions
Authors: Karvouni Evangelia , Stankovic Goran , Albiero Remo , Takagi Takuro , Corvaja Nicola , Vaghetti Marco , Di Mario Carlo , Colombo Antonio
Published: November 2004

The aim of the study was to evaluate the feasibility, safety, and efficacy of cutting balloon angioplasty in treatment of angiographically moderate and severe calcified coronary lesions. Thirty‐seven calcified coronary lesions (29 patients) detected by angiography were dilated with cutting balloon. Predilatation with plain balloon was performed in 27 (73.0%) lesions and stent was implanted in 23 (62.2%) lesions following cutting balloon. Acute gain following cutting balloon in predilated lesions was compared to the acute gain following plain balloon predilatation. For predilated lesions, acute gain after cutting balloon was significantly greater compared with plain balloon predilatation (1.51 ± 0.49 vs. 0.77 ± 0.42; P = 0.01). This result was achieved with larger size and lower pressure of cutting balloon compared with plain balloon (3.28 ± 0.46 vs. 2.94 ± 0.55, P = 0.01; 10.38 ± 1.64 vs. 13.19 ± 3.63, P = 0.001, respectively). The final gain following cutting balloon dilatation was significantly higher than the expected gain obtained by using a plain balloon of the same size (1.51 ± 0.49 vs. 0.93 ± 0.48; P < 0.0001), which was inflated at significantly higher pressure compared with cutting balloon. When we compared acute gain following cutting balloon in lesions with and without predilatation, we found no significant difference (P = 0.31). Angiographic success was achieved in 36 (97.3%) lesions and procedural success in 33 (89.1%) lesions. In‐hospital major adverse cardiac event (MACE) occurred in three (10.3%) patients. Follow‐up MACE was reported from three (10.3%) patients. In conclusion, cutting balloon angioplasty is feasible and safe in treatment of angiographically moderate and severe calcified lesions. Dilating efficiency of cutting balloon seems to be greater compared with a plain balloon of the same size, which was inflated at significantly higher pressure compared with cutting balloon. These results can be achieved with low in‐hospital MACE and are associated with a good long‐term outcome. Cathet Cardiovasc Intervent 2001;54:473–481. © 2001 Wiley‐Liss, Inc.
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzyme
Authors: Meunier Bernard , de Visser Samuel P. , Shaik Sason
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Recent Developments in Automated Structure Elucidation of Natural Products
Authors: Steinbeck Christoph
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Solid Solution of Ni in ErB4 and Its Crystal Structure.
Authors: Babizhetskyy V. S. , Veremchuk I. V. , Chaban N. F. , Kuz'ma Yu. B.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Phase Transition in the Cd6M Intermetallics.
Authors: Tamura R. , Edagawa K. , Aoki C. , Takeuchi S. , Suzuki K.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Thermodynamics and Equilibrium Phase Diagrams of the Zinc Halide + Silver Halide Systems
Authors: Wojakowska Alina , Gorniak Agata , Wojakowski Andrzej
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Formation of a Novel Type of Reverse Microemulsion System and Its Application in Synthesis of the Nanostructured La0.95Ba0.05MnAl11O19 Catalyst.
Authors: Teng Fei , Xu Jinguang , Tian Zhijian , Wang Junwei , Xu Yunpeng , Xu Zhusheng , Xiong Guoxing , Lin Liwu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Pentasupertetrahedral Clusters as Building Blocks for a Three‐Dimensional Sulfide Superlattice.
Authors: Zheng Nanfeng , Bu Xianhui , Feng Pingyun
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
New Aluminate with a Tetrahedral Structure Closely Related to the C84 Fullerene.
Authors: Boudin S. , Mellenne B. , Retoux R. , Hervieu M. , Raveau B.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Properties of Azoles and Their Derivatives. Part 52. Periselectivity of [2 + 3] Cycloaddition of Nitrones to trans‐β‐Cyanonitroethylene in the Light of FMO Theory.
Authors: Jasinski R. , Ciezkowska A. , Baranski A.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A New Class of Chiral P,N‐Ligands and Their Application in Palladium‐Catalyzed Asymmetric Allylic Substitution Reaction.
Authors: Lyle Michael P. A. , Narine Arun A. , Wilson Peter D.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Zn(Salen)‐Catalyzed Asymmetric Alkynylation of Ketones.
Authors: Saito Bunnai , Katsuki Tsutomu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Chiral BINOL‐Zinc Complex as a Novel Catalyst for the Enantioselective Epoxidation of α,β‐Enones.
Authors: Minatti Ana , Doetz Karl H.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Reactions of Cyclopropyl Aryl Ketones with Sulfonamides Mediated by Zr(OTf)4: Cascade Preparation of 5‐Aryl‐3,4‐dihydro‐2H‐pyrrole.
Authors: Shi Min , Yang Yong‐Hua , Xu Bo
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Heterobimetallic Rhodium(I)—Ruthenium(II) Catalyst for the Oppenauer‐Type Oxidation of Primary and Secondary Alcohols under Mild Conditions.
Authors: Gauthier Sebastien , Scopelliti Rosario , Severin Kay
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Chromium(VI) Catalyzed Oxidation of N‐Alkylamides to Imides with Periodic Acid.
Authors: Xu Liang , Zhang Suhong , Trudell Mark L.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Development of DIOP Derivatives as Efficient Ligands for Asymmetric Hydrogenation: Factors Controlling the Reactivities and Enantioselectivities.
Authors: Liu Duan , Li Wenge , Zhang Xumu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Efficient Oxidative ipso‐Fluorination of para‐Substituted Phenols Using Pyridinium Polyhydrogen Fluoride in Combination with Hypervalent Iodine(III) Reagents.
Authors: Karam Omar , Martin‐Mingot Agnes , Jouannetaud Marie‐Paule , Jacquesy Jean‐Claude , Cousson Alain
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Reformatsky Reaction of α‐Chloroesters with Carbonyl Compounds with Commercially Available Zinc.
Authors: Chavan Subhash P. , Shivasankar K. , Sivappa R.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Unsymmetrical Unsaturated Ketones from Lactones and Carboxylic Acids in One Step.
Authors: Giersch Wolfgang , Naef Ferdinand
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Development of Highly Diastereo‐ and Enantioselective Direct Asymmetric Aldol Reaction of a Glycinate Schiff Base with Aldehydes Catalyzed by Chiral Quaternary Ammonium Salts.
Authors: Ooi Takashi , Kameda Minoru , Taniguchi Mika , Maruoka Keiji
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of α‐Ketoamides from a Carbamoylsilane and Acid Chlorides.
Authors: Chen Jianxin , Cunico Robert F.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Thiophenol‐Mediated Hydrogen Atom Abstraction: An Efficient Tin‐Free Procedure for the Preparation of Cyclopentane Derivatives.
Authors: Beaufils Florent , Denes Fabrice , Renaud Philippe
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
One‐Pot Synthesis of Monosubstituted Aryl(hetaryl)acetylenes by Direct Introduction of the CCH Residue into Arenes and Hetarenes.
Authors: Vasilevsky Sergei F. , Klyatskaya Svetlana V. , Elguero Jose
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Direct Preparation of Allylic Indium(III) Reagents from Allylic Alcohols via a Reductive Transmetalation of π‐Allylnickel(II) with Indium(I) Iodide.
Authors: Hirashita Tsunehisa , Kambe Shinya , Tsuji Hiromitsu , Omori Hideki , Araki Shuki
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Solvent‐Dependent Diastereoselectivities in Reductions of β‐Hydroxyketones by SmI2.
Authors: Chopade Pramod R. , Davis Todd A. , Prasad Edamana , Flowers Robert A. II
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Carboxylation and Mitsunobu Reaction of Amines to Give Carbamates: Retention vs Inversion of Configuration Is Substituent‐Dependent.
Authors: Dinsmore Christopher J. , Mercer Swati P.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Enzyme Catalyzed Hydroxymethylation of Aromatic Aldehydes with Formaldehyde. Synthesis of Hydroxyacetophenones and (S)‐Benzoins.
Authors: Demir Ayhan S. , Ayhan Peruze , Igdir A. Cigdem , Duygu A. Nese
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of α‐Iminoimidates by Palladium‐Catalyzed Double Isonitrile Insertion.
Authors: Whitby Richard J. , Saluste C. Gustaf , Furber Mark
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Nitrile Anion Cyclization with Epoxysilanes Followed by Brook Rearrangement/Ring Opening of Cyclopropane Nitriles/Alkylation.
Authors: Okugawa Seigo , Takeda Kei
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Improved Preparation and Structural Investigation of 4‐Aryl‐4‐oxo‐2‐hydroxy‐2‐butenoic Acids and Methyl Esters.
Authors: Maurin Cedric , Bailly Fabrice , Cotelle Philippe
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Facile Conversion of Aryl Alkyl Ketones into Methyl 2‐Arylalkanoates Using Poly[4‐(diacetoxyiodo)styrene].
Authors: Sheng Shou‐Ri , Zhong Ming‐Hua , Liu Xiao‐Ling , Luo Qiu‐Yan , Chen Hui‐Zong
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Aryl Perfluoroalkyl Sulfides from Aromatic Disulfides.
Authors: Sipyagin A. M. , Enshov V. S. , Kashtanov S. A. , Potemkin V. A. , Thrasher J. S. , Waterfeld A.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Chloromethyl Sulfones from Sulfonyl Chlorides via a One‐Pot Procedure.
Authors: Antane Schuyler , Bernotas Ronald , Li Yanfang , McDevitt Robert , Yan Yinfa
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Straightforward Anionic Coupling for the Synthesis of ortho‐Bromobiaryls.
Authors: Becht Jean‐Michel , Ngouela Silvere , Wagner Alain , Mioskowski Charles
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Platinum(II)‐Catalyzed 1,6‐Diene Cycloisomerizations: Turnover in the Absence of β‐Hydride Elimination.
Authors: Kerber William D. , Koh Jeong Hwan , Gagne Michel R.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Methylsulfonyl and Hydroxyl Substituents Induce Z‐Stereocontrol in the McMurry Olefination Reaction.
Authors: Uddin Md. Jashim , Rao P. N. Praveen , Knaus Edward E.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Pressure Control of Diastereodifferentiating [2 + 2] Photocycloaddition of (E)‐Stilbene to Chiral Fumarate upon Direct and Charge‐Transfer Excitation.
Authors: Saito Hideaki , Mori Tadashi , Wada Takehiko , Inoue Yoshihisa
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
First Tandem Free‐Radical Cyclization Reaction of Alkylenecyclopropanes: A Novel and Efficient Method for the Preparation of 2‐(3,4‐Dihydronaphthalen‐2‐yl)malonic Acid Diethyl Esters.
Authors: Zhou Hongwei , Huang Xian , Chen Wanli
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Benzofurans from Isovanillin via C‐Propenylation‐o‐Vinylation and Ring‐Closing Metathesis.
Authors: Tsai Tzu‐Wei , Wang Eng‐Chi , Huang Keng‐Shiang , Li Sie‐Rong , Wang You‐Feng , Lin Yu‐Li , Chen Yung‐Hua
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Pyrroles from 1‐Dialkylamino‐3‐phosphoryl(or phosphanyl)allenes Through 1,5‐Cyclization of Conjugated Azomethine Ylide Intermediates.
Authors: Reisser Martin , Maas Gerhard
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Antiproliferative Activity of 3‐Aryl‐2‐[1H(2H)‐benzotriazol‐1(2)‐yl]acrylonitriles Variously Substituted. Part 4.
Authors: Carta Antonio , Palomba Michele , Boatto Gianpiero , Busonera Bernardetta , Murreddu Marta , Loddo Roberta
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
A Synthesis of 10‐Aryl‐2,7‐dimethyl‐4,5‐dioxo‐3,6,9‐trioxa‐3,4,5,6,9,10‐hexahydroanthra cene Catalyzed by KF‐Alumina.
Authors: Feng Youjian , Gao Yuan , Zhu Songlei , Li Tuanjie , Zhang Xiaojing , Tu Shujiang , Shi Daqing
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Bismuth Triflate Catalyzed One‐Pot Synthesis of Tetrahydrochromanoquinolines.
Authors: Babu K. Suresh , Raju B. China , Rao A. Sridhar , Kumar S. Praveen , Rao J. Madhusudana
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Oxamides as Novel NR2B Selective NMDA Receptor Antagonists
Authors: Domany Gyoergy , et al. et al.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Photochemically Catalyzed Diels—Alder Reaction of N‐Arylimines by 2,4,6‐Triphenylpyrylium Salt: Synthesis of Furo‐ and Pyranoquinoline Derivatives.
Authors: Zhang Wei , Guo Yanping , Yang Li , Liu Zhong‐Li
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Efficient Synthesis of 2‐ and 3‐Substituted‐2,3‐dihydro[1,4]dioxino[2,3‐b]pyridine Derivatives.
Authors: Lazar S. , Soukri M. , Leger J. M. , Jarry C. , Akssira M. , Chirita R. , Grig‐Alexa I. C. , Finaru A. , Guillaumet G.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
10‐Hydroxy‐10,9‐boroxarophenanthrenes: Versatile Synthetic Intermediates to 3,4‐Benzocoumarins and Triaryls.
Authors: Zhou Q. Jean , Worm Karin , Dolle Roland E.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Unusual Sesquiterpene Lactones from Ligularia virgaurea spp. oligocephala.
Authors: Wu Quan‐Xiang , Shi Yan‐Ping , Yang Li
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Triterpene Saponins from Knautia integrifolia var. bidens
Authors: Alankus‐Caliskan Oezgen , Emirdag Safiye , Bedir Erdal , Avunduk Sibel , Anil Hueseyin
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Diterpenes from the Heartwood of Chamaecyparis obtusa var. formosana.
Authors: Kuo Yueh‐Hsiung , Chen Chia‐Hsien , Chien Shih‐Chang , Lin Hsiu‐Chuan
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Convergent Formal Synthesis of (.+‐.)‐Heliannuols A, K, and L from a Common Intermediate.
Authors: Lecornue Frederic , Ollivier Jean
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Synthesis of (+)‐Nuciferal, (+)‐(E)‐Nuciferol and (+)‐α‐Curcumene by Chiral Hydrogenesterification Reaction.
Authors: Du Zhenting , Yue Guoren , Ma Junying , She Xuegong , Wu Tongxing , Pan Xinfu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel Routes to the Kainates: Stereoselectivity in Addition Reactions to Pyrrole[1,2c]‐oxazol‐3‐one
Authors: Murray A. J. , Parsons P. J. , Greenwood E. S. , Viseux E. M. E.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of Quaternary α‐ and β‐Amino Acids and β‐Lactams via Proline‐Catalyzed Mannich Reactions with Branched Aldehyde Donors.
Authors: Chowdari Naidu S. , Suri Jeff T. , Barbas Carlos F. III
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Polymer‐Bound Diphenylphosphane Hydrobromide, a Mild Acid for the Activation of Enol Ethers: Applications in Polymer‐Assisted Glycosidations.
Authors: Jaunzems Janis , Kashin Dmitri , Schoenberger Andreas , Kirschning Andreas
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Daphniglaucins D—H, J, and K, New Alkaloids from Daphniphyllum glaucescens.
Authors: Takatsu Hiroshi , Morita Hiroshi , Shen Ya‐Ching , Kobayashi Jun'ichi
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Concise Asymmetric Synthesis of (‐)‐Halosaline and (2R,9aR)‐(+)‐2‐Hydroxy‐quinolizidine by Ruthenium‐Catalyzed Ring‐Rearrangement Metathesis.
Authors: Lesma Giordano , Crippa Sergio , Danieli Bruno , Passarella Daniele , Sacchetti Alessandro , Silvani Alessandra , Virdis Andrea
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Structure—Affinity Relationships of 5′‐Aromatic Ethers and 5′‐Aromatic Sulfides as Partial A1 Adenosine Agonists, Potential Supraventricular anti‐Arrhythmic Agents.
Authors: Morrison Christopher F. , et al. et al.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Total Synthesis, Structure Revision, and Absolute Configuration of (+)‐Yatakemycin.
Authors: Tichenor Mark S. , Kastrinsky David B. , Boger Dale L.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Total Synthesis of (+)‐Eupenoxide and (+)‐Phomoxide: Revision of Structures and Assignment of Absolute Configuration.
Authors: Mehta Goverdhan , Roy Subhrangsu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Determination of the Absolute Structure of (+)‐Cystothiazole B.
Authors: Sasaki Takamitsu , Kato Keisuke , Akita Hiroyuki
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Two New Galloylglucosides from the Leaves of Mallotus furetianus.
Authors: Wei Kun , Li Wei , Koike Kazuo , Liu Lijuan , Fu Xiaowen , Lin Lianbo , Chen Yingjie , Nikaido Tamotsu
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Sodium‐Doped LaMnO3 Thin Films: Influence of Substrate and Thickness on Physical Properties.
Authors: Malavasi Lorenzo , Mozzati Maria Cristina , Alessandri Ivano , Depero Laura E. , Azzoni Carlo B. , Flor Giorgio
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Novel δ2‐Isoxazolines as Group II Phospholipase A2 Inhibitors.
Authors: Basappa Basappa , Kumar M. Satish , Swamy S. Nanjunda , Mahendra M. , Prasad J. Shashidhara , Viswanath B. S. , Rangappa K. S.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Estrogen Receptor Ligands. Part 5. The SAR of Dihydrobenzoxathiins Containing Modified Basic Side Chains.
Authors: Tan Qiang , et al. et al.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Nanostructures and Nanotechnology: Perspectives and New Trends
Authors: Tsakalakos Thomas
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Recent Advances in the Liquid‐Phase Syntheses of Inorganic Nanoparticles
Authors: Cushing Brian L. , Kolesnichenko Vladimir L. , O'Connor Charles J.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Crystallographic Group‐Subgroup Relations and Their Use in Crystal Chemistry
Authors: Mueller Ulrich
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Structure—Property Relations
Authors: several authors several authors
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
On the Way to “Solid Nitrogen” at Normal Temperature and Pressure? Binary Azides of Heavier Group 15 and 16 Elements
Authors: Knapp Carsten , Passmore Jack
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Ionic Liquids for the Convenient Synthesis of Functional Nanoparticles and Other Inorganic Nanostructures
Authors: Antonietti Markus , Kuang Daibin , Smarsly Bernd , Zhou Yong
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Metal‐Directed Self‐Assembled Systems
Authors: Costisor Otilia , Linert Wolfgang
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Coordination Polymers: Infinite Systems
Authors: Kitagawa S. , Noro S.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Homooxacalixarenes. Part 1. Structure, Synthesis, and Chemical Reactions
Authors: Shokova E. A. , Kovalev V. V.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Cyclizations of Organolithiums onto Aromatic Rings
Authors: Clayden Jonathan , Kenworthy Martin N.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Development of the Ti‐Catalyzed Intermolecular Hydroamination of Alkynes
Authors: Doye Sven
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Physiologically Potent β‐Amino Alcohols
Authors: Lee Hee‐Seung , Kang Sung Ho
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Radical Cyclization of Haloacetals: The Ueno—Stork Reaction
Authors: Salom‐Roig Xavier J. , Denes Fabrice , Renaud Philippe
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Towards Perfect Catalytic Asymmetric Synthesis: Dual Activation of the Electrophile and the Nucleophile
Authors: Ma Jun‐An , Cahard Dominique
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Chemistry of Selenabenzenes and Related Compounds
Authors: Honda Eiji , Kataoka Tadashi
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
New Cyclic and Polymeric Phosphazenes Derived from N‐Silylphosphoranimines
Authors: Wang Bin , Klaehn John R. , Neilson Robert H.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Chemical Reactivity of Alumazene
Authors: Pinkas Jiri , Loebl Jiri , Roesky Herbert W.
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Zwitterionic Phospholide Derivatives: New Ambiphilic Ligands
Authors: Gudat Dietrich
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Geminal Dithiols
Authors: Voronkov Mikhail , Shagun Lyudmila , Ermolyuk Larisa , Timokhina Lyudmila
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Multiple Channel Reaction Dynamics Using Universal Crossed Molecular Beam Techniques
Authors: Yang Xueming
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Theoretical Dynamics Treatment of Chemical Reactions
Authors: Zhang J. Z. H. , Li Yi M. , Wang Ming L. , Xiang Yun
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Electronic Structure and Chemical Reaction in Solution
Authors: Sato Hirofumi
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Field‐Cycling NMR Relaxometry
Authors: Kimmich Rainer , Anoardo Esteban
Published: November 2004

For Abstract see ChemInform Abstract in Full Text.
Intratumoral administration of a 1,2‐dimyristyloxypropyl‐3‐ dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine formulation of the human interleukin‐2 gene in the treatment of metastatic renal cell carcinoma
Authors: Galanis Evanthia , Burch Patrick A. , Richardson Ronald L. , Lewis Bradley , Pitot Henry C. , Frytak Stephen , Spier Catherine , Akporiaye Emmanuel T. , Peethambaram Prema P. , Kaur Judith S. , Okuno Scott H. , Unni Krishnan K. , Rubin Joseph
Published: November 2004

BACKGROUND

Leuvectin (Vical Inc., San Diego, CA) is a gene transfer product in which a plasmid encoding the human interleukin‐2 (IL‐2) gene is complexed with the cationic lipid 1,2‐dimyristyloxypropyl‐3‐dimethylhydroxyethyl ammonium bromide/dioleoylphosphatidylethanolamine (DMRIE/DOPE). In the current study, the authors investigated the safety and efficacy of in situ vaccination with Leuvectin in patients with metastatic renal cell carcinoma.

METHODS

Thirty‐one patients with metastatic renal cell carcinoma were treated with intratumorally administered Leuvectin at doses ranging from 0.75 to 4 mg. These patients subsequently were evaluated for response and for treatment‐related toxicity.

RESULTS

Treatment was well tolerated: no Grade 3 or 4 toxicities were observed in association with the study agent. Documented side effects included Grade 1 pain at the injection site (20%); mild (i.e., Grade 1 or 2) constitutional symptoms, including malaise/myalgia, low‐grade fever, and chills (74%); Grade 1 fatigue (19%); Grade 1 or 2 nausea (10%); and Grade 2 allergy (1 occurrence). Two patients experienced partial responses, which endured for 32 months and 6 years, respectively, and 1 patient currently is experiencing a pathologic complete response, which, to date, has persisted for 50 months; thus, the overall response rate was 10%. In addition, 7 patients (23%) experienced disease stabilization for a median of 8 months (range, 4–48 months). The median duration of survival from the start of Leuvectin treatment was 11 months (range, 2–72 months), with a 1‐year survival rate of 48% and a 3‐year survival rate of 19%. Laboratory analysis of tumor samples revealed the presence of IL‐2 plasmid DNA in six of eight patients posttreatment, increased IL‐2 expression in tumor cells in four of eight patients posttreatment, and increased tumor infiltration by CD8‐positive lymphocytes in five of eight patients posttreatment.

CONCLUSIONS

Immunotherapy with intratumorally administered Leuvectin is safe and can lead to durable objective responses in patients with metastatic renal cell carcinoma. Cancer 2004. © 2004 American Cancer Society.
Expression of the pro‐apoptotic protein ARTS in astrocytic tumors
Authors: Gottfried Yossi , Voldavsky Eugene , Yodko Lena , Sabo Edmond , Ben‐Itzhak Ofer , Larisch Sarit
Published: November 2004

BACKGROUND

Apoptosis (i.e., programmed cell death) plays a major role in the development of astrocytic tumors, which are the most common tumors of the central nervous system. ARTS, a proapoptotic protein that is localized in the mitochondria, promotes apoptosis by functioning as an XIAP antagonist and a caspase activator.

METHODS

To investigate the role of ARTS in astrocytoma, the authors examined protein expression and apoptotic activity in 72 astrocytic tumors, which included low‐grade astrocytomas, anaplastic astrocytomas, and glioblastomas.

RESULTS

Whereas normal astrocytes did not express the ARTS protein, astrocytoma cells strongly expressed ARTS, and the expression of this protein increased with increasing tumor grade. Furthermore, increased levels of ARTS were significantly associated with higher rates of apoptosis (as measured using the terminal deoxynucleotidyltransferase–mediated deoxyuridine triphosphate nick end‐labeling [TUNEL] assay as well as an immunohistochemical staining assay for active caspase‐3) in these tumors. Levels of two other apoptosis‐related proteins, p53 and Bcl‐2, also were examined using immunohistochemical methods; ARTS expression was found to be positively correlated with expression of the former and negatively correlated with expression of the latter, which is known to possess antiapoptotic activity.

CONCLUSIONS

The results of the current study suggest that ARTS levels reliably reflect the ability of cells to undergo apoptosis, which serves as a defense mechanism against the development and progression of astrocytoma. Furthermore, ARTS expression, when taken into consideration in combination with tumor grade, was the only independent predictor of survival identified in the current analysis. Thus, the authors conclude that ARTS may possess utility as a prognostic marker, as well as a therapeutic tool, for patients with astrocytoma. Cancer 2004. © 2004 American Cancer Society.
Loss of GM1 surface expression precedes annexin V‐phycoerythrin binding of neutrophils undergoing spontaneous apoptosis during in vitro aging
Authors: Sheriff Ahmed , Gaipl Udo S. , Franz Sandra , Heyder Petra , Voll Reinhard E. , Kalden Joachim R. , Herrmann Martin
Published: November 2004

Background

Apoptosis of neutrophil granulocytes is an important determinant of the resolution of inflammation. Apoptotic neutrophils undergo specific alterations in their receptor profiles. These alterations are likely to contribute to the characteristic functional silencing of the dying cells.

Methods

By flow cytometry and fluorescence microscopy, we analyzed the ganglioside GM1, a lipid raft marker, with respect to its surface expression on neutrophil and eosinophil granulocytes. Apoptosis was monitored by morphological changes and by the binding of annexin V‐phycoerythrin (AxV‐PE).

Results

GM1, which was stained by the cholera toxin subunit B, was found only on neutrophil granulocytes; eosinophil granulocytes did not bind cholera toxin subunit B. GM1 was lost from the surfaces of neutrophils before AxV‐PE binding (early apoptosis). Surprisingly, GM1 reappeared during the late stages of apoptosis, although without functional consequences. GM1 was found on the cell surface and in intracellular membranes, whereas CD16 was found only at the cell surface.

Conclusions

Loss of surface GM1 is a new marker for the detection of the aging of neutrophils. Its loss precedes the binding of AxV‐PE of neutrophils. © 2004 Wiley‐Liss, Inc.
Bioconversion of D,L‐tert‐leucine Nitrile to D‐tert‐leucine by Recombinant Cells expressing Nitrile Hydratase and D‐selective Amidase
Authors: Brandão P.F.B. , Verseck S. , Syldatk C.
Published: November 2004

This project is aimed at studying the feasibility of producing D‐tert‐leucine (D‐Tle) from racemic tert‐leucine‐nitrile (Tle‐nitrile) using nitrile‐transforming enzymes. For the conversion of Tle‐nitrile to D‐Tle, a bacterial strain, previously recovered from a deep‐sea sediment, Rhodococcus erythropolis 870‐AN019, was used, which expresses a nitrile hydratase (NHase)/amidase system for nitrile metabolism. This strain was able to perform the sequential conversion of the nitrile to the acid, via the intermediate racemic tert‐leucine amide (Tle‐amide). However, the activities of both enzymes were low and the amidase was found to be L‐selective. A developed recombinant E. coli strain, expressing the NHase of R. erythropolis 870‐AN019, showed a 10‐fold increase in activity, compared to the wild type strain. A second recombinant E. coli expressing the D‐selective amidase from Variovorax paradoxus 19–3 was used to complete the conversion of the racemic amide into D‐Tle. The optimal pH and temperature ranges for the enzymes activities were, 7–9 and 30–40 °C, respectively, for the NHase, and 7–9.5 and 47–49 °C, respectively, for the D‐amidase. Thus, a compromise between the optimal biotransformation temperatures was necessary in order to achieve satisfactory activities for both enzymes in one pot reactions. In addition, the D‐amidase activity towards Tle‐amide was 10‐fold lower than the recombinant NHase towards Tle‐nitrile, indicating that a higher concentration of the first enzyme was necessary during biotransformations. The sequential conversion to produce D‐Tle was achieved using a whole cell mixture of both recombinant strains in one pot reactions at different temperatures. A temperature of 35 °C appeared to be the best compromise to obtain good activity of both enzymes in the same reaction. A fed‐batch biotransformation of Tle‐nitrile produced 700 mg of D‐Tle in 4.5 h, however, unconverted nitrile and L‐amide were still present. The accumulation of unconverted amide resulted in the inhibition of the NHase that lead to the accumulation of nitrile, which further inhibited both NHase and D‐amidase. Since both enzymes were inhibited by Tle‐nitrile and Tle‐amide, a continuous process, which would control the concentration of these compounds in the reactor, was investigated. Alginate co‐immobilized whole cells were used in a continuous stirred tank reactor biotransformation to attempt the production of D‐Tle from Tle‐nitrile, but this procedure did not improve the productivity.
Identification and Expression in E. coli of Novel Nitrile Hydratases from the Metagenome
Authors: Liebeton K. , Eck J.
Published: November 2004

A PCR‐based screening procedure using degenerate consensus primers was employed to identify nitrile hydratase (NHase) encoding genes in libraries of cloned environmental DNA. Screening of about 3 Gbp of metagenomic DNA led to the identification of twelve novel and highly diverse NHase α‐subunits, ten β‐subunits, and three NHase activator proteins. The disruption of the natural arrangement of the genes encoding the NHase subunits and a reduced temperature proved to be beneficial for the soluble expression in E. coli. Of nine NHases investigated, six were produced in an active conformation. The co‐expression of corresponding activator proteins resulted in the activation of a previously inactive enzyme and a marked increase in activity of another enzyme. Thus, the sequence‐homology based screening approach led to the identification and finally the production of novel and diverse NHase enzymes.
Fish as bioindicators to assess the effects of pollution in two southern Brazilian rivers using the Comet assay and micronucleus test
Authors: de Andrade Vanessa Moraes , da Silva Juliana , da Silva Fernanda R. , Heuser Vanina D. , Dias Johnny F. , Yoneama Maria Lúcia , de Freitas Thales R.O.
Published: November 2004

Industrial effluents, agricultural runoff, and municipal wastewaters contain unknown substances and complex mixtures that are released into the environment and can lead to contamination of surface and subsurface waters. In the present report, we have used the alkaline Comet assay and the micronucleus (MN) test to detect the genotoxicity due to multiple sources of pollution in the peripheral blood of two native estuarine fish (mullet and sea catfish) and evaluated possible interactive genotoxic effects from multiple contaminants and the seasonal variation of the genotoxicity. Mullet and sea catfish were captured in the Tramandaí and Mampituba Rivers in the southern Brazilian state of Rio Grande do Sul. Reference animals were obtained from the Armazém lagoon. Fish captured in the two estuaries during the four seasons over a period of 2 years had increased levels of DNA damage and MN frequencies relative to the reference fish. In general, the alkaline Comet assay was more sensitive to the genotoxicity of the river contaminants than the MN test. The Comet assay demonstrated significant differences in fish captured at different seasons and at the two river sites, while the MN test showed significant differences only for the annual average for mullet from both sites and fish from the control site. The increases in DNA damage appear to be related to the increase in the number of people in the towns close to the study areas during the warm spring and summer seasons. Although no specific cause‐effect relationships were established, comparison of the chemical contaminants and physical variations in the rivers with the genotoxicity data indicate that there may be some association between hydrocarbons, metals, pH, and water temperature and the level of damaged cells observed in mullet and sea catfish from the Tramandaí and Mampituba estuaries. Environ. Mol. Mutagen. 2004. © 2004 Wiley‐Liss, Inc.
Household‐level determinants of survey nonresponse
Authors: Couper Mick P. , Groves Robert M.
Published: November 2004

A theoretical framework is presented that addresses the influence of household‐level factors on survey cooperation.
A template for assessing the organizational base for program implementation
Authors: Scheirer Mary Ann
Published: November 2004

This chapter details use of a template for examining the factors and processes underlying program implementation and delivery; it provides methods and practical advice for using a template to guide implementation.
Defining and describing the paradigm issue in mixed‐method evaluation
Authors: Greene Jennifer C. , Caracelli Valerie J.
Published: November 2004

Current stances on mixing methods and paradigms are described and critiqued. Ideas are offered for advancing mixed‐method evaluation beyond age‐worn paradigm debates.
The landscape of values in evaluation: Charted terrain and unexplored territory
Authors: Schwandt Thomas A.
Published: November 2004

Examining ethical questions about practice can make evaluators more critical of what they are doing: What is it to be a good evaluator? In whose interests should we be acting and to what purpose?
Advances in quantitative evaluation, 1987–1996
Authors: Rossi Peter H.
Published: November 2004

Advances in quantitative methods enable evaluators to collect and analyze data more efficiently, more cost‐effectively, and with greater precision and sensitivity.
Developing the Guiding Principles
Authors: Shadish William R. , Newman Dianna L. , Scheirer Mary Ann , Wye Christopher
Published: November 2004

This chapter presents some history relevant to the American Evaluation Association Guiding Principles for Evaluators, the processes used to create them, and some of the issues considered and controversies examined in the process.
Unemployment variation over the business cycles: a comparison of forecasting models
Authors: Moshiri Saeed , Brown Laura
Published: November 2004

Asymmetry has been well documented in the business cycle literature. The asymmetric business cycle suggests that major macroeconomic series, such as a country's unemployment rate, are non‐linear and, therefore, the use of linear models to explain their behaviour and forecast their future values may not be appropriate. Many researchers have focused on providing evidence for the non‐linearity in the unemployment series. Only recently have there been some developments in applying non‐linear models to estimate and forecast unemployment rates. A major concern of non‐linear modelling is the model specification problem; it is very hard to test all possible non‐linear specifications, and to select the most appropriate specification for a particular model.
Artificial neural network (ANN) models provide a solution to the difficulty of forecasting unemployment over the asymmetric business cycle. ANN models are non‐linear, do not rely upon the classical regression assumptions, are capable of learning the structure of all kinds of patterns in a data set with a specified degree of accuracy, and can then use this structure to forecast future values of the data. In this paper, we apply two ANN models, a back‐propagation model and a generalized regression neural network model to estimate and forecast post‐war aggregate unemployment rates in the USA, Canada, UK, France and Japan. We compare the out‐of‐sample forecast results obtained by the ANN models with those obtained by several linear and non‐linear times series models currently used in the literature. It is shown that the artificial neural network models are able to forecast the unemployment series as well as, and in some cases better than, the other univariate econometrics time series models in our test. Copyright © 2004 John Wiley & Sons, Ltd.
CO Desorption Rate Dependence on CO Partial Pressure over Platinum Fuel Cell Catalysts
Authors: Davies J. C. , Nielsen R. M. , Thomsen L. B. , Chorkendorff I. , Logadóttir Á. , Lodziana Z. , Nørskov J. K. , Li W. X. , Hammer B. , Longwitz S. R. , Schnadt J. , Vestergaard E. K. , Vang R. T. , Besenbacher F.
Published: November 2004

Carbon monoxide adsorption on high area platinum fuel cell catalysts was investigated. Isotopic exchange experiments were performed to determine the exchange rate (k) of CO under different partial pressures of CO (pCO) in argon. A linear dependence of ln(k) with ln(pCO) was observed. This pressure dependence of the rate of exchange is explained by considering a change in surface coverage of CO with different CO pressures and a subsequent reduction in the CO binding energy as demonstrated by Density Functional Theory (DFT) calculations. High Pressure Scanning Tunneling Microscopy (HP STM) studies on the Pt(111) surface have also displayed a pressure dependency of the coverage consistent with this data. The relevance of these observations to the Polymer Electrolyte Membrane Fuel Cell (PEMFC) anode reaction is discussed.
Turbulent heat transfer of natural convection between two vertical parallel plates
Authors: Inagaki Terumi , Maruyama Shinji
Published: November 2004

We measure heat transfer coefficients of natural convection between two vertical smooth parallel plates heated uniformly in the laminar, transition, and turbulent regions. The heat transfer characteristics are experimentally investigated with changing width, δ, between the vertical parallel plates, wall heat flux, qw, overall watercourse length, L,of the vertical parallel plate and heating conditions. For natural convection between the vertical parallel plates, in the turbulent region of $Ra_{x}^{*} > 10^{14}$, the heat transfer is strongly suppressed owing to the effect of combined convection. On the contrary, the heat transfer in the laminar region is enhanced due to the tunnel effect. These tendencies become pronounced with decreasing δ and increasing L.The location of the heat transfer reduction shifts downstream with increasing qw under a fixed δ. Furthermore, under smaller δ, we cannot clearly distinguish the transition process in accordance with both the heat transfer enhancement in the laminar region and the heat transfer reduction in the turbulent region. © 2001 Scripta Technica, Heat Trans Asian Res, 31(1): 56–67, 2002
Role of AKT/PKB signaling in fibroblast growth factor‐1 (FGF‐1)‐induced angiogenesis in the chicken chorioallantoic membrane (CAM)
Authors: Forough Reza , Weylie Brian , Patel Chirag , Ambrus Sandy , Singh Ugra S. , Zhu James
Published: November 2004

Transfection of chicken chorioallantoic membranes (CAMs) with a chimeric secreted version of fibroblast growth factor‐1 (sp‐FGF‐1) gene construct leads to a significant increase in vascularization. Though FGF‐stimulated angiogenesis has been extensively studied, the molecular mechanisms regulating FGF‐1‐induced angiogenesis are poorly understood in vivo. This study was designed to investigate the role of the AKT (PKB) kinase signaling pathway in mediating sp‐FGF‐1‐induced angiogenesis in the chicken CAM. The involvement of the AKT pathway was demonstrated by up‐regulation of AKT1 mRNA expression in sp‐FGF‐1 compared to vector alone control transfected CAMs as demonstrated by real‐time RT‐PCR. Western analysis using an antibody specific to the activated AKT (phosphorylated AKT), demonstrated an increase in AKT activity in sp‐FGF‐1 compared to vector control transfected CAMs. More importantly, the AKT inhibitor ML‐9 significantly reduced sp‐FGF‐1‐induced angiogenesis in CAMs. These results indicate that AKT signaling plays a role in FGF‐1‐stimulated angiogenesis in vivo and the AKT pathway may serve as a therapeutic target for angiogenesis‐associated diseases. © 2004 Wiley‐Liss, Inc.
Doxycycline‐ and tetracycline‐regulated transcriptional silencer enhance the expression level and transactivating performance of rtTA
Authors: Lai Jen‐Feng , Cheng Hsin‐Yuan , Cheng Tzu‐Ling , Lin Yu‐Yu , Chen Li‐Chieh , Lin Mau‐Ting , Jou Tzuu‐Shuh
Published: November 2004

Background

The tetracycline‐regulated transcriptional silencer (tTS) has been demonstrated to mitigate leaky expression of the tetracycline‐inducible promoter under uninduced condition, and, when conjugated with reverse‐type tetracycline‐controlled transactivator (rtTA), shows great promise for gene therapy. This effect was attributed to the effectiveness of tTS as a repressor of transcription at the tetracycline‐regulated promoter. However, we observed an unexpected increase in transactivational activity by rtTA in the presence of tTS under inducible condition.

Methods

To explore the nature of this co‐activational effect of tTS on rtTA, we examined the expression patterns of rtTA by Western blotting analysis of total cellular lysates or an enriched ubiquitinated pool of proteins under various conditions, including the one when proteasomal degradation is inhibited.

Results

We demonstrate tTS, in addition to its established role as a transcriptional silencer, can enhance rtTA expression level by salvaging rtTA from the ubiquitin‐dependent proteasomal degradation pathway. Along with this finding, we also demonstrate that doxycycline, a commonly used tetracycline analogue, inhibits the susceptibility of rtTA to ubiquitin/proteasome‐mediated degradation and enhances the expression level of rtTA.

Conclusions

Taken together, our data establish an unappreciated role of doxycycline and tTS in tetracycline‐regulated gene expression and the functionality of rtTA, and should shed light on the design of gene therapy vectors based on tetracycline‐controlled transcriptional regulation systems. Copyright © 2004 John Wiley & Sons, Ltd.