bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19, Long COVID Syndrome, and Mental Health Sequelae in a Mexican Population
Authors: Villalpando Jesús Maximiliano Granados , Forcelledo Humberto Azuara , Castillo Jorge Luis Ble , Sastré Alejandro Jiménez , Rojop Isela Esther Juárez , Hernández Viridiana Olvera , Canabal Fernando Enrique Mayans , Priego Crystell Guadalupe Guzmán
Published: June 2022

The COVID-19 pandemic is currently a worldwide threat and concern, not only because of COVID-19 itself but its sequelae. The aim of this study was to evaluate whether a relation between COVID-19, Long COVID, and the prevalence of mental health disorders exist. A total of 203 people from Tabasco were included in this study, answering a survey integrated by three dominions: General and epidemiological data, the DASS-21 test (to determine the presence of signs or symptoms suggestive of depression, anxiety, and/or stress) and an exploratory questionnaire about Long COVID syndrome. A descriptive and inferential statistical analysis was made via Microsoft Excel and Graphpad Prism software, evaluating differences through the Mann–Whitney U test and considering p < 0.05 as statistically significant. Of the 203 people surveyed, 96 (47.29%) had had COVID-19 and 107 (52.71%) had not; from the ones that had COVID-19, 29 (30.21%) presented mental health disorders and 88 (91.66%) presented at least one symptom or sign of Long COVID syndrome; meanwhile, 31 (32.29%) presented 10 or more symptoms or signs. From the comparison between the population with previous mental health disorders and COVID-19 and those without background disorders or COVID-19, the results were the following: 27.58% vs. 16.82% presented severe depression, 48.27% vs. 17.75% presented severe anxiety, and 27.58% vs. 20.56% presented severe stress. A high prevalence of mental health effects was observed in patients without COVID-19 and increased in the population with Long COVID syndrome and previous mental health disorders.
Differences in Unfavorable Lifestyle Changes during the COVID-19 Pandemic between People with and without Disabilities in Finland: Psychological Distress as a Mediator
Authors: Holm Marja Eliisa , Sainio Päivi , Suvisaari Jaana , Sääksjärvi Katri , Jääskeläinen Tuija , Parikka Suvi , Koskinen Seppo
Published: June 2022

We investigated whether people with disabilities—cognition, vision, hearing, mobility, or at least one of these disabilities—report more COVID-19-related negative lifestyle changes than those without disabilities, and whether psychological distress (MHI-5) mediates the association between disabilities and negative lifestyle changes. Information about COVID-related lifestyle changes among people with disabilities is scarce. We analyzed population-based data from the 2020 FinSote survey carried out between September 2020 and February 2021 in Finland (n = 22,165, aged 20+). Logistic regressions were applied to investigate the effect of the COVID-19 pandemic and related restrictions on negative lifestyle changes—sleeping problems or nightmares, daily exercise, vegetable consumption, and snacking. To test for a mediation effect of psychological distress, the Karlson–Holm–Breen method was used. People with all disability types reported increased sleeping problems or nightmares, and decreased vegetable consumption during the pandemic more frequently than those without. People with mobility and cognitive disabilities more frequently reported decreased daily exercise. People with cognitive disabilities more often reported increased snacking. Psychological distress mediated associations between disabilities and negative lifestyle changes, with the highest association between cognitive disabilities and increased sleeping problems or nightmares (B = 0.60), and the lowest between mobility disabilities and decreased daily exercise (B = 0.08). The results suggest that strategies to promote healthy lifestyles should consider people with disabilities. Alleviating their psychological distress during crisis situations could be one approach.
Digitally Inclusive, Healthy Aging Communities (DIHAC): A Cross-Cultural Study in Japan, Republic of Korea, Singapore, and Thailand
Authors: Aung Myo Nyein , Koyanagi Yuka , Nagamine Yuiko , Nam Eun Woo , Mulati Nadila , Kyaw Myat Yadana , Moolphate Saiyud , Shirayama Yoshihisa , Nonaka Kumiko , Field Malcolm , Cheung Paul , Yuasa Motoyuki
Published: June 2022

One out of three people in Japan will be an older person before 2040. Half of those currently do not utilize the internet, smartphone apps, or digital technology. On the other hand, more than 70% of seniors in Republic of Korea use the internet, and 55% in Singapore had access to it in 2019. The use of digital technology for health promotion has the potential to promote individual and community empowerment, advocating for healthy, active aging. Maintaining equity in health promotion practice requires the digital inclusion of every senior. Therefore, we propose a cross-cultural study to explain the contextual influences of digital inclusion and its consequences on healthy aging in Japan, Korea, Singapore, and Thailand. Quantitatively: digital skills, e-health literacy, participation in health promotion, and quality of life will be analyzed in structural equation models. Qualitatively: thematic analysis will be developed to identify cultural patterns and contextual factors, making sense of what older persons in different countries materialize, say, do, think, and feel to reveal deeper beliefs and core values about digital inclusion and healthy aging. Logics and methods from this protocol would be useful to replicate the study in many countries globally. Evidence from this study is expected to pave the way to digitally inclusive, healthy aging communities (DIHAC) across Japan and Asia.
“Sehat Sahulat Program”: A Leap into the Universal Health Coverage in Pakistan
Authors: Hasan Syed Shahzad , Mustafa Zia Ul , Kow Chia Siang , Merchant Hamid A.
Published: June 2022

Universal Health Coverage (UHC), initiative from the World Health Organization (WHO), is a means to provide the human right to health by providing essential health services to everyone, enabling disease prevention, treatment, rehabilitation, and palliative care. In line with the WHO recommendations, the UHC was first introduced in Pakistan in Khyber Pakhtunkhwa (KP) province under the name ‘Sehat Sahulat Programme’ (SSP), literally ‘Health Facility Program’ in 2015. The provincial Government in Punjab approved a similar initiative in Punjab, the largest province (by population) of the country, and the program was later rolled out in Islamabad Capital Territory (ICT), Azad and Jammu Kashmir (AJK), Gilgit Baltistan (GB), Sindh, and Baluchistan provinces leaping into the nation-wide coverage. This article provides a current overview of the UHC initiative in Pakistan, analyses its progress in appraising key milestones, and makes recommendations to achieve a robust universal health coverage across Pakistan.
Usability Evaluation and Classification of mHealth Applications for Type 2 Diabetes Mellitus Using MARS and ID3 Algorithm
Authors: Gupta Kamaldeep , Roy Sharmistha , Altameem Ayman , Kumar Raghvendra , Saudagar Abdul Khader Jilani , Poonia Ramesh Chandra
Published: June 2022

The rapid growth of mHealth applications for Type 2 Diabetes Mellitus (T2DM) patients’ self-management has motivated the evaluation of these applications from both the usability and user point of view. The objective of this study was to identify mHealth applications that focus on T2DM from the Android store and rate them from the usability perspective using the MARS tool. Additionally, a classification of these mHealth applications was conducted using the ID3 algorithm to identify the most preferred application. The usability of the applications was assessed by two experts using MARS. A total of 11 mHealth applications were identified from the initial search, which fulfilled our inclusion criteria. The usability of the applications was rated using the MARS scale, from 1 (inadequate) to 5 (excellent). The Functionality (3.23) and Aesthetics (3.22) attributes had the highest score, whereas Information (3.1) had the lowest score. Among the 11 applications, “mySugr” had the highest average MARS score for both Application Quality (4.1/5) as well as Application Subjective Quality (4.5/5). Moreover, from the classification conducted using the ID3 algorithm, it was observed that 6 out of 11 mHealth applications were preferred for the self-management of T2DM.
Personality Traits and Sociodemographic Factors Associated with the Use of E-Cigarettes, Waterpipe and Conventional Cigarettes among Medical University Students
Authors: Yew Shen Yap , Ramzi Nurul Hanis , Gopinath Divya
Published: June 2022

This study aimed to investigate the prevalence and sociodemographic characteristics of smokers in a private medical university in Malaysia and to examine whether there is an association between personality traits and various smoking types. There were 468 participants in this study and the mean age was 20.97 years (±2.743). The prevalence of conventical cigarette users, e-cigarette users, and water pipe users was 4.7%, 6.4%, and 4.0%, respectively. Parents’ annual income (p = 0.001) and ethnicity (p < 0.001) were significantly associated with the current smoker group. Binary logistic regression modelling revealed that study participants with either Malay (OR 4.23, 95% CI 1.73, 10.34) or Chinese (OR 4.16, 95% CI 1.98, 8.73) ethnicity were approximately four times more likely to use tobacco products compared with study participants with Indian and Other ethnicities. Lower parents’ annual income was almost four times more likely to be associated with smoking behaviour (OR 3.82, 95% CI 1.58, 9.27). Significant differences in mean personality traits score of Openness (p = 0.018) and Extraversion (p = 0.004) were observed between never-smoker and current smoker study participants. In addition, cigarette users scored higher in Conscientiousness personality traits compared with non-cigarette whereas e-cigarette users and waterpipe users scored lower in Extraversion (p = 0.02). Post-hoc analysis revealed that the never-smoker group scored higher in Extraversion compared with the dual tobacco user group (p = 0.03). In addition, the single tobacco user group scored higher in Agreeableness personality trait compared with the never-smoker group (p = 0.01). Deeper understanding of the different cognitive dimensions, ethnicities, and educational backgrounds can potentially impact smoking prevention and cessation programs.
Cascading Risks for Preventable Infectious Diseases in Children and Adolescents during the 2022 Invasion of Ukraine
Authors: Maggioni Andrea , Gonzales-Zamora Jose A. , Maggioni Alessandra , Peek Lori , McLaughlin Samantha A. , von Both Ulrich , Emonts Marieke , Espinel Zelde , Shultz James M.
Published: June 2022

Russia’s military incursion into Ukraine triggered the mass displacement of two-thirds of Ukrainian children and adolescents, creating a cascade of population health consequences and producing extraordinary challenges for monitoring and controlling preventable pediatric infectious diseases. From the onset of the war, infectious disease surveillance and healthcare systems were severely disrupted. Prior to the reestablishment of dependable infectious disease surveillance systems, and during the early months of the conflict, our international team of pediatricians, infectious disease specialists, and population health scientists assessed the health implications for child and adolescent populations. The invasion occurred just as the COVID-19 Omicron surge was peaking throughout Europe and Ukrainian children had not received COVID-19 vaccines. In addition, vaccine coverage for multiple vaccine-preventable diseases, most notably measles, was alarmingly low as Ukrainian children and adolescents were forced to migrate from their home communities, living precariously as internally displaced persons inside Ukraine or streaming into European border nations as refugees. The incursion created immediate impediments in accessing HIV treatment services, aimed at preventing serial transmission from HIV-positive persons to adolescent sexual or drug-injection partners and to prevent vertical transmission from HIV-positive pregnant women to their newborns. The war also led to new-onset, conflict-associated, preventable infectious diseases in children and adolescents. First, children and adolescents were at risk of wound infections from medical trauma sustained during bombardment and other acts of war. Second, young people were at risk of sexually transmitted infections resulting from sexual assault perpetrated by invading Russian military personnel on youth trapped in occupied territories or from sexual assault perpetrated on vulnerable youth attempting to migrate to safety. Given the cascading risks that Ukrainian children and adolescents faced in the early months of the war—and will likely continue to face—infectious disease specialists and pediatricians are using their international networks to assist refugee-receiving host nations to improve infectious disease screening and interventions.
Symptoms of Anxiety, Depression, and Post-Traumatic Stress Disorder in Health Care Personnel in Norwegian ICUs during the First Wave of the COVID-19 Pandemic, a Prospective, Observational Cross-Sectional Study
Authors: Stafseth Siv Karlsson , Skogstad Laila , Ræder Johan , Hovland Ingvild Strand , Hovde Haakon , Ekeberg Øivind , Lie Irene
Published: June 2022

Background: The COVID-19 pandemic has induced demanding work situations in intensive care units (ICU). The objective of our study was to survey psychological reactions, the disturbance of social life, work effort, and support in ICU nurses, physicians, and leaders. Methods: From May to July 2020, this cross-sectional study included 484 ICU professionals from 27 hospitals throughout Norway. Symptoms of anxiety and depression were measured on Hopkins Symptom Checklist-10 (HSCL-10). Symptoms of post-traumatic stress disorder (PTSD) were measured on the PCL-5. Results: The study population were highly educated and experienced professionals, well prepared for working with COVID-ICU patients. However, 53% felt socially isolated and 67% reported a fear of infecting others. Probable cases of anxiety and depression were found in 12.5% of the registered nurses, 11.6% of the physicians, and 4.1% of the leaders. Younger age and <5 years previous work experiences were predictors for high HSCL-10 scores. Reported symptom-defined PTSD for nurses 7.1%; the leaders, 4.1%; and 2.3% of physicians. Conclusions: ICU health care professionals experienced talking with colleagues as the most helpful source of support. The COVID-ICU leaders reported a significantly higher mean score than physicians and nurses in terms of pushing themselves toward producing high work effort.
Speech Impaired by Half Masks Used for the Respiratory Tract Protection
Authors: Nowacki Krzysztof , Łakomy Karolina , Marczak Wojciech
Published: June 2022

Filtering half masks belong to the group of personal protective equipment in the work environment. They protect the respiratory tract but may hinder breath and suppress speech. The present work is focused on the attenuation of sound by the half masks known as “filtering facepieces”, FFPs, of various construction and filtration efficiency. Rather than study the perception of speech by humans, we used a generator of white noise and artificial speech to obtain objective characteristics of the attenuation. The generator speaker was either covered by an FFP or remained uncovered while a class 1 meter measured sound pressure levels in 1/3 octave bands with center frequencies 100–20 kHz at distances from 1 to 5 m from the speaker. All five FFPs suppressed acoustic waves from the octave bands with center frequencies of 1 kHz and higher, i.e., in the frequency range responsible for 80% of the perceived speech intelligibility, particularly in the 2 kHz-octave band. FFPs of higher filtration efficiency stronger attenuated the sound. Moreover, the FFPs changed the voice timbre because the attenuation depended on the wave frequency. The two combined factors can impede speech intelligibility.
Functionality of Apps for People with Autism: Comparison between Educators from Florence and Granada
Authors: Gallardo-Montes Carmen del Pilar , Rodríguez Fuentes Antonio , Caurcel Cara María Jesús , Capperucci Davide
Published: June 2022

Background: Studies on the potential of smartphone apps for people with autism are currently increasing in number, given the large digital supply available and the benefits they offer. We analyzed the opinion of educators from Florence (Italy) and Granada (Spain) regarding the benefits and applicability of apps, frequency of their use, and the type of apps used for people with autism. Methods: The study involved 1261 professionals, of whom 286 worked with apps, using a non-experimental quantitative design, descriptive and frequency statistics, parametric inferential analyses (Student’s t and one-factor ANOVA), and calculation of the effect size (Cohen’s d and eta squared) and intrafactorial correlations. Results: Statistically significant differences were observed in respect of city, sex, age, years of experience, place of work, and type of teacher. The teachers from Granada found more benefits and applicability in apps, and revealed a slightly higher usage than those from Florence. Conclusions: It is an arduous but worthy task for professionals from schools and associations that work with people with autism to acquire the necessary knowledge to apply methodologies based on information and communication technology (ICT), as this will help achieve the integrated development of people with different capabilities.
Agave Syrup: Chemical Analysis and Nutritional Profile, Applications in the Food Industry and Health Impacts
Authors: Saraiva Ariana , Carrascosa Conrado , Ramos Fernando , Raheem Dele , Raposo António
Published: June 2022

Agave syrup (AS), a food product made from agave plant sap, is a vegan sweetener that has become popular for replacing conventional sweeteners such as sucrose. As the demand for naturally derived sweeteners has grown in the last decade, this review paper addresses and discusses, in detail, the most relevant aspects of the chemical AS analysis, applications in the food industry, sustainability issues, safety and quality control and, finally, nutritional profile and health impacts. According to our main research outcome, we can assume that the mid-infrared-principal components analysis, high-performance anion exchange chromatography equipped with a pulsed amperometric detector, and thin-layer chromatography can be used to identify and distinguish syrups from natural sources. The main agave–derived products are juice, leaves, bagasse, and fiber. In sustainability terms, it can be stated that certified organic and free trade agave products are the most sustainable options available on the market because they guarantee products being created without pesticides and according to specific labor standards. The Mexican government and AS producers have also established Mexican guidelines which prohibit using any ingredient, sugar or food additive that derives from sources, apart from agave plants, to produce any commercial AS. Due to its nutritional value, AS is a good source of minerals, vitamins and polyphenols compared to other traditional sweeteners. However, further research into the effects of AS on human metabolism is necessary to back its health claims as a natural sugar substitute.
Association between Bar Closing Time, Alcohol Use Disorders and Blood Alcohol Concentration: A Cross-Sectional Observational Study of Nightlife-Goers in Perth, Australia
Authors: Gilmore William , Symons Martyn , Liang Wenbin , Graham Kathryn , Kypri Kypros , Miller Peter , Chikritzhs Tanya
Published: June 2022

Introduction and aims: Associations between bar trading hours, a government lever for controlling alcohol availability, nightlife-goer intoxication levels and their likelihood of alcohol use disorder (AUD) have not been explored. We investigated whether: (i) participant AUD was associated with blood alcohol concentration (BAC); and, (ii) any association between AUD and BAC was moderated by participant preferred bar (i.e., venue spent most time at) closing time. Design and methods: A cross-sectional observational study using a sample of nightlife-goers who went out drinking in Perth, Western Australia, on weekends in 2015-16. Participants who reported alcohol use that night and spent most time in a bar (n = 667) completed street intercept surveys including AUDIT-C (n = 459) and provided a breath sample to estimate BAC (n = 651). We used gender-specific multinomial logistic regression models to explore associations between participant AUDIT-C score (1–4, lower risk; 5–7, hazardous; 8–12, active AUD), preferred bar type (standard vs. late closing time based on absence or presence of an extended trading permit) and BAC (male: 0–0.049, 0.05–0.099, ≥0.1 g/100 mL; female: 0–0.049, 0.05–0.079, ≥0.08 g/100 mL). Results: Males with active AUD (RR = 3.31; 95% CI 1.30–8.42; p = 0.01) and females with hazardous/active AUD (RR = 9.75; 95% CI 2.78–34.21; p < 0.001) were both more likely to have high-range BAC than their counterparts typically drinking at lower risk. We also found preferred bar type moderated the association between AUDIT-C score and BAC for some males but no females. Males with active AUD and high-range BAC were less likely to prefer late closing bars than males usually drinking at lower risk and high-range BAC (RR = 0.12; 95% CI 0.02–0.96; p = 0.046). Discussion and conclusions: Our study provides evidence of positive associations between AUD and acute intoxication among nightlife-goers and on the moderating effect of bar closing times among males.
Developing of Multidimensional Perspectives Checklist of Professionalism for Undergraduate Occupational Therapy Students in Assistive Technology Service: Delphi Study
Authors: Hung Chia-Hui , Wang Yu-Ming , Huang Cheng-Yi , Lin Chung-Hui
Published: June 2022

Professionalism is a critical attribute that occupational therapy students must establish throughout education, especially in the context of assistive technology (AT). This study aimed to construct a multidimensional perspectives checklist (MPC) from the stakeholders to reflect professionalism development in the AT service courses. Fifteen experts in AT clinical practice and educators (N = 15) consented to and completed three rounds of the Delphi survey. Data were qualitatively analyzed to form a preliminary checklist in the first round. In rounds two and three, participants rated their level of agreement with the MPC items. A descriptive analysis of consensus was performed. Thirty items were classified into five subscales (teachers, therapists, patients, peers, learners) and fit into a framework with three dimensions and seven categories. After the Delphi survey, the MPC achieved high consensus, convergence, and stability. Two additional categories of professionalism emerged in the study, namely aesthetic and personal characteristics and reflection. The MPC developed in this study reflects the perspectives of various stakeholders in occupational therapy practice, providing helpful information for students to prepare themselves. Therefore, the MPC could contribute to expanding and developing the scope of professionalism in occupational therapy, especially in AT service.
Validation Study of a Value-Based Digital Health Questionnaire
Authors: Nuño-Solinís Roberto , Urizar Elena , Merino Marisa , Del Barrio Jaime , Errea Rodríguez María
Published: June 2022

The paradigm of value-based health care is spreading worldwide; however, Value-Based Digital Health (VBDH) is still an emerging concept. VBDH is understood as the use of digital tools to facilitate the generation of value in health. It is accelerated by technological change, cultural, and organizational factors. An accurate diagnosis of the organizational VBDH maturity is crucial to define and implement strategic actions to progress with VBDH transformation. This study aimed to validate a VBDH questionnaire, which measures the degree of maturity of VBDH from the perspective of managers (N = 146) in Spanish healthcare organizations. Results show good internal consistency of the questionnaire. Factor analysis identified seven dimensions to measure VBHC maturity: (1) Resources, incentives, and financing; (2) Knowledge and participation of patients and workers in the strategy of progress towards VBDH; (3) Training of professionals and tool knowledge for advancement in VBDH; (4) Innovation initiatives; (5) Information and its quality; (6) Leadership, strategy and governance; and (7) Knowledge of the fundamentals and objectives, as well as access to relevant VBDH information. The questionnaire presents good validity and internal consistency and meets the requirements to be an instrument for routine use to assess VBDH organizational maturity.
Influence of Information Sources on Chinese Parents Regarding COVID-19 Vaccination for Children: An Online Survey
Authors: Li Kai , Zhou Fen
Published: June 2022

(1) Aims: This study explored the mechanism by which exposure to different information sources on social media influences Chinese parents’ intention to vaccinate their children against COVID-19. (2) Methods: We developed a research framework based on the Stimulus–Organism–Response (SOR) theory to illustrate how exposure to information sources on social media increases vaccine confidence and, as a result, parents’ intentions regarding pediatric vaccination. The partial least square structural equation modeling (PLS-SEM) method was used to test the data collected through an online survey (687 valid samples). (3) Results: The government approval of vaccines fuels vaccination confidence and acts as a mediator between (a) mass media, government new media, and key opinion leaders, and (b) perceived effectiveness and side effects (safety) of vaccines. (4) Conclusions: The mass media, government new media, and key opinion leaders are crucial sources for encouraging parents to vaccinate their children since they boost the vaccination trust. The focus of COVID-19 vaccination promotion should be to strengthen parents’ trust in the government, combined with publicizing the effectiveness and side effects (safety) of vaccines.
Hesitancy towards the Third Dose of COVID-19 Vaccine among the Younger Generation in Japan
Authors: Khan Mostafa Saidur Rahim , Nguyen Trinh Xuan Thi , Lal Sumeet , Watanapongvanich Somtip , Kadoya Yoshihiko
Published: June 2022

The younger generation’s hesitancy towards the COVID-19 vaccine in Japan received significant attention during the early stages of vaccination. However, there is a lack of a comprehensive study in Japan that analyzes the apprehension towards the third dose of vaccine, commonly known as the booster dose, and its underlying causes. Using data from an online panel survey conducted by the Hiroshima Institute of Health Economics Research at Hiroshima University, we examined the severity of booster dose aversion among youths of different ages. Our findings indicate that a sizeable proportion of the Japanese population, particularly younger men, are hesitant to receive the booster dose. Furthermore, an inter-age group difference in booster dose aversion exists only among men. According to the probit regression results, subjective health status and future anxiety are associated with the booster vaccine hesitancy of men and women of various age groups. Moreover, few socioeconomic and behavioral factors like marital status, having children, household income and assets, and having a myopic view of the future, are also associated with the booster dose aversion among youths of certain ages. Given the diverse attitude of the younger generation, our findings suggest that public health authorities should develop effective communication strategies to reduce vaccine apprehension in the society.
Motivations and Personal Traits Can Predict Self-Efficacy of the Clown Therapist: A Descriptive Study
Authors: Diotaiuti Pierluigi , Mancone Stefania , Corrado Stefano
Published: June 2022

The individual and collective perception of self-efficacy in clown therapists is fundamental in order to be able to be active, restrained, energetic and defocused, if necessary, without being overwhelmed by any problems patients might have. The present study evaluated both the incidence of motivational and dispositional functions on the level of perceived self-efficacy with a sample of 259 Italian clown therapists who were administered The Volunteer Self-Efficacy Scale, the Volunteer Process Model and the Italy Personality Inventory. The significance of a hierarchical linear regression model of perceived self-efficacy was tested. The results showed that the value orientation of the operators mainly influenced the level of perceived self-efficacy, that is, the search for actions with a high social meaning, rather than the orientation towards situations and experiences that allow one to expand one’s knowledge and promote one’s own person. Profiles with higher perceived self-efficacy were associated with the trait of dynamism and conscientiousness, while a person’s vulnerability was found to be a significant negative predictor of self-efficacy. An additional significant predictor was the experience of the clown therapist. The results of the study also showed a positive and functional role of the synergy conferred by teamwork. The group mitigates the emotional difficulties of the individual and supports him/her by orienting him/her technically and compensating for any inexperience in the field of animation in sensitive contexts, such as hospital wards with serious and vulnerable patients, such as children.
Transcultural Validation of a Spanish Version of the Quality of Life in Epidermolysis Bullosa Questionnaire
Authors: Villar Hernández Alvaro , Molero Alonso Fernando , Aguado Marín Álvaro , Posada de la Paz Manuel
Published: June 2022

Introduction: Epidermolysis bullosa (EB) is a relatively infrequent genodermatosis for which there is still no cure, and which impacts the quality of life of those that are affected by it. The Quality of Life evaluation in Epidermolysis Bullosa (QoLEB) questionnaire was specifically developed for English-speaking persons with EB. Objectives: To undertake the transcultural adaptation and analysis of the psychometric properties of a Spanish version of the QoLEB questionnaire. Method: We designed an observational study to implement the process of translation and validation of the scale in accordance with World Health Organisation guidelines. We assessed the content validity of the Spanish version with the participation of 33 adult patients who presented with four principal subtypes of EB. The subjects were examined and evaluated using the QoLEB and Short Form-36 (SF-36) questionnaires. Results: The Spanish version of the QoLEB displayed excellent internal consistency and content validity, α = 0.91. Test–retest reliability was likewise excellent (ps = 0.93), as was the reliability among subtypes (range ps = 0.82–0.93). The functional part of the QoLEB correlated well with the SF-36 physical component summary (ps = 0.70). The emotional QoLEB was moderately correlated with the SF-36 mental component summary (ps = 0.49). Significant discriminant validity existed between the global score of the questionnaire (p = 0.033) and the functional scale (p = 0.003). Conclusions: The Spanish version of the QoLEB questionnaire can be recommended for use in any subsequent studies seeking to assess the efficacy of possible treatments and care programmes in this group.
Unintentional Tobacco Smoke Exposure in Children
Authors: Zhang Caseng , Lam Kaden , Hicks Patrick , Hicks Matt , Brennan Lesley , Buka Irena , Hicks Anne
Published: June 2022

Secondhand smoke (SHS) exposure increases the prevalence and severity of sinopulmonary diseases in children. The primary source of SHS exposure in children is through adults who live in the same house; however, the level of exposure may vary based on the adult smoking habits at home. This prospective cross-sectional study in Alberta, Canada, investigated the relationship between self-reported caregiver smoking, location, outdoor temperature and children’s’ urine cotinine: creatinine ratio (CCR), a marker of nicotine metabolism. Participants aged 0–9 were recruited from the Child Health Clinics at the Misericordia Community Hospital in Edmonton, Alberta, from 8 January to 24 February 2016 and 30 June to 18 August 2016. Participant CCR levels were compared to caregiver-reported smoking location and environmental factors such as temperature and season. Of the 233 participants who reported smoking status, 21% reported smoking, in keeping with local smoking rates. More participants smoked indoors during the winter than the summer; however, some families limited indoor smoking to a garage. Of the 133 parent–child dyads who provided smoking information and a child urine sample, 18 had an elevated cotinine:creatinine ratio, suggestive of significant tobacco smoke exposure, 15 of whom were from homes that reported smoking. Age < 1 year and number of cigarettes smoked in the home weekly were risks for significant exposure while season, outdoor temperature and smoking location in the home did not reach significance. Smokers should be counseled to protect children, particularly infants, from exposure by limiting the number of cigarettes smoked and isolating smoking to outside the home. Segregated areas such as a garage may provide a useful harm mitigation strategy for indoor smokers, provided the garage does not share ventilation or is not in close proximity to high-traffic areas of the home.
Positive Effect of Air Purifier Intervention on Baroreflex Sensitivity and Biomarkers of Oxidative Stress in Patients with Coronary Artery Disease: A Randomized Crossover Intervention Trial
Authors: Eom Sang-Yong , Kim Aryun , Lee Ju-Hee , Kim Sang Min , Lee Sang-Yeub , Hwang Kyung-Kuk , Lim Hyun-Joung , Cho Myeong-Chan , Kim Yong-Dae , Bae Jang-Whan , Kim Jun Hyung , Lee Dae-In
Published: June 2022

Exposure to fine particulate matter increases the risk of cardiovascular morbidity and mortality. Few studies have tested the beneficial effect of indoor air filtration intervention in patients with cardiovascular disease. The aim of this study is to investigate the effect of air filtration on mitigating cardiovascular health in patients with coronary artery disease. This randomized, double-blind, crossover study is conducted with 38 coronary artery disease patients. The intervention consists of the following three periods: two-week active and sham air filtration interventions, with a two-week washout period. The indoor PM2.5 concentration is continuously monitored during the entire study period. We measure the blood pressure, heart rate variability, baroreflex sensitivity, autonomic function test results, and endothelial function. The two-week active air filtration intervention for two weeks reduces the average indoor concentration of PM2.5 by 33.9%. The indoor PM2.5 concentration is significantly correlated to cross-correlation baroreflex sensitivity. Active air filtration is significantly associated with a decrease in the indicator of oxidative stress represented as 8-hydroxy-2′-deoxyguanosine. This study shows that a short-term air filtration intervention improved baroreflex sensitivity and might reduce oxidative stress in coronary artery disease patients. These findings suggest that the use of an air purifier could mitigate the recurrence of cardiovascular disease events in patients with coronary artery disease.
Cardiovascular Disease Mortality Attributable to Low Whole-Grain Intake in CHINA: An Age-Period-Cohort and Joinpoint Analysis
Authors: Chen Fangyao , Zhang Yuxiang , Chen Shiyu , Si Aima , Hu Weiwei
Published: June 2022

Cardiovascular disease (CVD) is the leading cause of death worldwide. Low whole-grain intake is found to be one of the most important risk factors for cardiovascular disease development and progression. In this study, we focused on exploring the long-term trends of low whole-grain intake attributed to cardiovascular disease mortality in China during 1990–2019 and relative gender differences. Study data were obtained from the Global Burden of Disease (GBD) 2019 study. We used the age-period-cohort model to estimate the adjusted effect of age, period, and cohorts. Annual and average annual percentage changes were estimated by joinpoint regression analysis. We observed an increasing trend with a net drift of 1.208% for males and 0.483% for males per year. The longitudinal age curve suggested that the attributed rate increased for both genders. Period and cohort effects all suggested that the risk for males showed an increased trend that was higher than that of females. Our findings suggest that males and senior-aged people were at a higher risk of cardiovascular disease mortality attributed to low whole-grain intake. Effective strategies are needed to enhance people’s health consciousness, and increasing whole-grain intake may achieve a better preventive effect for cardiovascular disease.
Analysis of Domestic and International Green Infrastructure Research Trends from the ESG Perspective in South Korea
Authors: Lee Eunjoung , Kim Gunwoo
Published: June 2022

Government-level ESG (environmental, social, and governance) institutionalization and active ESG activation in the private sector are being discussed for the first time this year in Korea, spurred by increased national interest since the COVID-19 pandemic crisis and the declaration of a carbon-neutral society by 2050, and ESG discussion in many fields is spreading rapidly. In addition, global awareness of the crisis caused by environmental pollution and natural disasters has highlighted the importance of green infrastructure (GI) as a new conceptual alternative to improve public value. Based on sustainability, which is a common goal of ESG and green infrastructure, this study aimed to examine the research targets and techniques of green infrastructure from the perspective of ESG. This study selected and analyzed 98 domestic and international academic journal papers published over the past 10 years in the Web of Science academic journal database literature collection. Focusing on the research subjects, the focus on green infrastructure, and research keywords, we examined the aspects of the green infrastructure plan that have been focused on from the ESG perspective and compared domestic and international research trends. In addition, implications for how each research topic is connected to the concept of ESG according to its function and purpose were derived. By examining the domestic and international research trends of green infrastructure from the ESG perspective, we identified the need for a wider range of research on the diversity and relationship between humans and the ecological environment; policies and systems; and technical research that does not focus only on a specific field. In this regard, we intend to increase the contribution to ESG management in the public sector through the establishment of green infrastructure plans and policies in the future, as they account for a large portion of public capital.
Investigation of Synergistic Effects and Kinetics on Co-Pyrolysis of Alternanthera philoxeroides and Waste Tires
Authors: Shujaa Aldeen Awsan , Wang Jiapeng , Zhang Bo , Tian Shuying , Xu Zhixiang , Zhang Huiyan
Published: June 2022

A thermogravimetric analysis is used to analyze the thermal kinetics and investigate the synergistic effects between Alternanthera philoxeroides (AP) and waste tires (WTS) in a temperature range of 50–900 °C under three heating rates (15, 25, and 35 °C/min). Two model-free methods (FWO and KAS) and a model-fitting method (CR) were applied to calculate the activation energy. Results revealed that heating rates had no significant effect on the pyrolysis operation. The addition of WTS improved the thermal degradation of the samples as the samples had more than one stage during the main reaction period. A promoting synergistic effect was found in the blend 75A25WT and obtained the lowest activation energy among all the blends without a catalyst, while the blend 50A50WT exhibited an inhibiting effect. On the other hand, the addition of HZSM-5 accelerated the reaction time and obtained the lowest activation energy among all the blends without a catalyst. Furthermore, ΔW of 75A25WT+C was the lowest, indicating that the blend with a catalyst exhibited the strongest synergistic effect. This research confirmed that the addition of WTS improved the thermal parameters of the samples and clarified the capacity of HZSM-5 to reduce the activation energy.
Alteration of Inflammatory Parameters and Psychological Post-Traumatic Syndrome in Long-COVID Patients
Authors: Clemente Irma , Sinatti Gaia , Cirella Antonio , Santini Silvano Junior , Balsano Clara
Published: June 2022

The aim of our study is to evaluate the correlation between the psychological status of patients recovered from SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection (long-COVID patients) and their inflammatory status. Three months after hospital discharge, ninety-three patients were recruited and categorized into two distinct populations: control and long-COVID (COrona VIrus Disease) group. Patients belonging to the control group presented with an entering diagnosis of cardiovascular, metabolic, or respiratory disease and a negative history of SARS-CoV-2 infection, whereas the long-COVID population presented with a severe SARS-CoV-2 infection treated in the sub-intensive Care Unit. Psychological evaluation was performed through the administration of the Symptom Checklist-90 (SCL90) and LDH (Lactate dehydrogenase), ferritin, CRPhs (C-high sensitivity Reactive Protein), NLR (Neutrophil-to-lymphocyte ratio), PLR (Platelet-to-lymphocyte ratio), and SII (systemic immune-inflammation index) were investigated. We highlighted that beyond the first three months after contagion, patients recovered from SARS-CoV-2 infection are characterized by the persistence of a systemic inflammatory state and are at high risk for developing somatization, depression, anxiety, and sleep disturbances. Interestingly, ferritin value was strongly correlated with sleep disorders (p < 0.05). Our study emphasizes how COVID-19 strategies for risk stratification, prognosis, and therapy management of patients should be implemented with a psychological follow-up.
The Association between Differentiation of Self and Life Satisfaction among Chinese Emerging Adults: The Mediating Effect of Hope and Coping Strategies and the Moderating Effect of Child Maltreatment History
Authors: Guo Xiamei , Huang Jingwen , Yang Yuexia
Published: June 2022

Background: Differentiation of self (DoS) is a core construct in Bowen family systems theory. At the interpersonal level, it represents the capacity to maintain rational thinking rather than reacting emotionally, especially while under stress. Previous studies have demonstrated the positive association between DoS and life satisfaction. The current study aims to investigate the mediating roles of hope and coping strategies on this association, and whether the mediation mechanism was moderated by participants’ experience of child maltreatment. Methods: The current sample consisted of 447 Chinese college students recruited from three Chinese universities. DoS, life satisfaction, hope and coping strategies, as well as childhood maltreatment history, were measured via self-report. Structural equation modeling was used to test the proposed mediation and moderation effect. Results: Participants who were maltreated in childhood (n = 149) exhibited significantly lower levels of DoS, hope, and positive coping strategies than the comparison group (n = 298) at baseline and lower life satisfaction at the 3-month follow-up. Structural equation modeling analysis showed that coping strategies mediated the association between DoS and life satisfaction for both the maltreated and comparison groups. Hope appeared to have a significant mediating effect only among those in the comparison group. Conclusions: The current findings lend support to Bowen’s theoretical statement regarding the role of DoS on psychological well-being, with an incorporated viewpoint of Snyder’s hope theory.
A Scoping Review of Available Tools in Measurement of the Effectiveness of Conservative Treatment in Lipoedema
Authors: Czerwińska Monika , Teodorczyk Jacek , Hansdorfer-Korzon Rita
Published: June 2022

(1) Background: Due to insufficient knowledge of lipoedema, the treatment of this disease is undoubtedly challenging. However, more and more researchers attempt to incorporate the most effective lipoedema treatment methods. When assessing a new therapeutic method, choosing correct, objective tools to measure the therapeutic outcome is very important. This article aims to present possible instruments that may be used in the evaluation of therapeutic effects in patients with lipoedema. (2) Methods: The data on therapeutic outcome measurements in lipoedema were selected in February 2022, using the Medical University of Gdansk Main Library multi-search engine. (3) Results: In total, 10 papers on this topic have been identified according to inclusion criteria. The tools evaluating the therapeutic outcomes used in the selected studies were: volume and circumference measurement, body mass index, waist-to-hip ratio, ultrasonography and various scales measuring the quality of life, the level of experiencing pain, the severity of symptoms, functional lower extremity scales, and a 6 min walk test. (4) Conclusion: The tools currently used in evaluating the effectiveness of conservative treatment in women with lipoedema are: volume and circumference measurement, waist-to-hip ratio, body fat percentage, ultrasonography, VAS scale, quality of life scales (SF-36, RAND-36), symptom severity questionnaire (QuASiL), Lower Extremity Functional Scale and 6 min walk. Choosing a proper tool to measure the treatment outcome is essential to objectively rate the effectiveness of therapeutic method.
Risk Measurement of Perinatal and Neonatal Morbidity Characteristics and Applicability of GAIA Case Definitions: Results and Lessons Learnt of a Hospital-Based Prospective Cohort Study in the Valencia Region (2019–2020)
Authors: Carmona Antonio , Latorre Tejerina María , Martínez Sebastián Alicia , Dobreva Dafina , Jurca Cristina P. , Huerta Barberá Sergio , Bernat Montoya Vicente , Aristoy Zabaleta Mercedes , Pineda Caplliure Ana , Mansilla Roig Beatriz , Navío Anaya María , Tosca-Segura Ricardo , Tortajada-Girbés Miguel , Díez-Domingo Javier , Orrico-Sánchez Alejandro
Published: June 2022

Post-marketing safety surveillance of new vaccines aimed to be administered during pregnancy is crucial to orchestrate efficient adverse events evaluation. This is of special relevance in the current landscape of new vaccines being introduced in the pregnant women population, and particularly due to the recent administration of COVID-19 vaccines in pregnant women. This multi-center prospective cohort study, nested within the WHO-Global Vaccine Safety-MCC study, involved two hospitals in the Valencia region. Hereby, the incidence rates of seven perinatal and neonatal outcomes in the Valencia region are presented. The pooled data analysis of the two Valencian hospitals allowed the estimation of incidence rates in the Valencia Region (per 1000 live births): 86.7 for low birth weight, 78.2 for preterm birth, 58.8 for small for gestational age, 13 for congenital microcephaly, 0.4 for stillbirth, 1.2 for neonatal death and 6.5 for neonatal infection. These figures are in line with what is expected from a high-income country and the previously reported rates for Spain and Europe, except for the significantly increased rate for congenital microcephaly. Regarding the data for maternal immunization, the vaccination status was collected for 94.4% of the screened pregnant women, highlighting the high quality of the Valencian Vaccine Registry. The study also assessed the Valencian hospitals’ capacity for identifying and collecting data on maternal immunization status, as well as the applicability of the GAIA definitions to the identified outcomes.