bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension
Authors: D’Amico Reid , Faley Shannon , Shim Ha-na , Prosser Joanna , Agrawal Vineet , Bellan Leon , West James
Published: August 2018

Endothelial dysfunction is a known consequence of bone morphogenetic protein type II receptor (BMPR2) mutations seen in pulmonary arterial hypertension (PAH). However, standard 2D cell culture models fail to mimic the mechanical environment seen in the pulmonary vasculature. Hydrogels have emerged as promising platforms for 3D disease modeling due to their tunable physical and biochemical properties. In order to recreate the mechanical stimuli seen in the pulmonary vasculature, we have created a novel 3D hydrogel-based pulmonary vasculature model (“artificial arteriole”) that reproduces the pulsatile flow rates and pressures seen in the human lung. Using this platform, we studied both Bmpr2R899X and WT endothelial cells to better understand how the addition of oscillatory flow and physiological pressure influenced gene expression, cell morphology, and cell permeability. The addition of oscillatory flow and pressure resulted in several gene expression changes in both WT and Bmpr2R899X cells. However, for many pathways with relevance to PAH etiology, Bmpr2R899X cells responded differently when compared to the WT cells. Bmpr2R899X cells were also found not to elongate in the direction of flow, and instead remained stagnant in morphology despite mechanical stimuli. The increased permeability of the Bmpr2R899X layer was successfully reproduced in our artificial arteriole, with the addition of flow and pressure not leading to significant changes in permeability. Our artificial arteriole is the first to model many mechanical properties seen in the lung. Its tunability enables several new opportunities to study the endothelium in pulmonary vascular disease with increased control over environmental parameters.
Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
Authors: Sabol Maja , Trnski Diana , Musani Vesna , Ozretić Petar , Levanat Sonja
Published: August 2018

GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.
Tracking of Adipose-Derived Mesenchymal Stromal/Stem Cells in a Model of Cisplatin-Induced Acute Kidney Injury: Comparison of Bioluminescence Imaging versus qRT-PCR
Authors: Schubert Ralf , Sann Julia , Frueh Jochen T. , Ullrich Evelyn , Geiger Helmut , Baer Patrick C.
Published: August 2018

Determining the cell fate and the distribution of mesenchymal stromal/stem cells (MSCs) after transplantation are essential parts of characterizing the mechanisms of action and biosafety profile of stem cell therapy. Many recent studies have shown that MSCs migrate into injured tissues, but are only detectable at extremely low frequencies. We investigated the cell fate of MSCs after transplantation in an acute kidney injury (AKI) mouse model using in vivo bioluminescence imaging (BLI) and subsequent verification of cell migration using quantitative real-time polymerase chain reaction (qRT-PCR). The AKI was induced by a single injection of cisplatin (8 or 12 mg/kg). One day later, adipose-derived mesenchymal stromal/stem cells isolated from luciferase transgenic mice (Luc+-mASCs, 5 × 105) were intravenously transplanted. Migration kinetics of the cells was monitored using BLI on day 1, 3, and 6, and finally via quantitative real-time PCR at the endpoint on day 6. Using BLI, infused Luc+-mASCs could only be detected in the lungs, but not in the kidneys. In contrast, PCR endpoint analysis revealed that Luc-specific mRNA could be detected in injured renal tissue; compared to the control group, the induction was 2.2-fold higher for the 8 mg/kg cisplatin group (p < 0.05), respectively 6.1-fold for the 12 mg/kg cisplatin group (p < 0.001). In conclusion, our study demonstrated that Luc-based real-time PCR rather than BLI is likely to be a better tool for cell tracking after transplantation in models such as cisplatin-induced AKI.
Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy
Authors: Johnson Benjamin W. , Achyut Bhagelu R. , Fulzele Sadanand , Mondal Ashis K. , Kolhe Ravindra , Arbab Ali S.
Published: August 2018

Recent evidence suggests that myeloid cells are critical in cancer development and therapy resistance processes. Pharmacological targeting of tumor-associated myeloid cells is an emerging approach among upcoming immune therapies. Surprisingly, myeloid cells are heterogeneous, including a subset of the myeloid cell displaying angiogenic properties in solid tumors. There is an urgent need to delineate angiogenic myeloid cell populations in order to facilitate specific targeting of protumor myeloid cells among heterogeneous pool. This review article is intended to compile all the relevant information in the literature for improved understanding of angiogenic myeloid cells and their role in tumor refractoriness to cancer therapy.
Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors
Authors: García María del Carmen , Pazos Patricia , Lima Luis , Diéguez Carlos
Published: August 2018

Obesity rates and the burden of metabolic associated diseases are escalating worldwide Energy burning brown and inducible beige adipocytes in human adipose tissues (ATs) have attracted considerable attention due to their therapeutic potential to counteract the deleterious metabolic effects of nutritional overload and overweight. Recent research has highlighted the relevance of resident and recruited ATs immune cell populations and their signalling mediators, cytokines, as modulators of the thermogenic activity of brown and beige ATs. In this review, we first provide an overview of the developmental, cellular and functional heterogeneity of the AT organ, as well as reported molecular switches of its heat-producing machinery. We also discuss the key contribution of various interleukins signalling pathways to energy and metabolic homeostasis and their roles in the biogenesis and function of brown and beige adipocytes. Besides local actions, attention is also drawn to their influence in the central nervous system (CNS) networks governing energy expenditure.
PsCor413pm2, a Plasma Membrane-Localized, Cold-Regulated Protein from Phlox subulata, Confers Low Temperature Tolerance in Arabidopsis
Authors: Zhou Aimin , Liu Enhui , Li He , Li Yang , Feng Shuang , Gong Shufang , Wang Jingang
Published: August 2018

Low temperature stress adversely affects plant growth and development. Isolation and characterization of cold response genes from cold-tolerant plants help to understand the mechanism underlying low temperature tolerance. In this study, PsCor413pm2, a cold-regulated (COR) gene isolated from Phlox subulata, was transferred to Arabidopsis plants to investigate its function. Real-time quantitative PCR analysis revealed that PsCor413pm2 expression was induced by cold. Subcellular localization revealed that the PsCor413pm2-green fluorescent protein (GFP) fusion protein localized to the plasma membrane in tobacco and Arabidopsis plants. Furthermore, overexpression of PsCor413pm2 in Arabidopsis plants enhanced tolerance to low temperature stress. Transgenic Arabidopsis roots had more influx of Ca2+ after a cold shock than wild-type plants, as shown using non-invasive micro-test technology (NMT). Moreover, the transcription abundance of five COR and two C-repeat (CRT) binding factor (CBF) genes in transgenic Arabidopsis plants was higher than that in the wild-type plants under cold stress. Taken together, our results suggest that overexpression of PsCor413pm2 enhances low temperature tolerance in Arabidopsis plants by affecting Ca2+ flux and the expression of stress-related COR and CBF genes.
Evaluation of Eosin-Methylene Blue as a Photosensitizer for Larval Control of Aedes aegypti by a Photodynamic Process
Authors: Lima Alessandra R. , Silva Cicera M. , Caires Cynthia S. A. , Prado Esmael D. , Rocha Luciana R. P. , Cabrini Isaias , Arruda Eduardo J. , Oliveira Samuel L. , Caires Anderson R. L.
Published: August 2018

Aedes aegypti (Ae. aegypti) is a competent vector for transmitting important viral diseases such as yellow fever, dengue, chikungunya, and Zika. Several strategies have been applied to avoid Ae. aegypti proliferation by using environmental management, biological, and chemical approaches. However, the development of new methods for effective control of the insect vector population is still needed. Photodynamic control is an alternative way to control the vector population by using a physical approach based on the larval phototoxicity of a photosensitizer. In this context, the present study evaluated the use of eosin-methylene blue (EMB) as a new photosensitizer for photodynamic control of Ae. aegypti larval populations. The photodynamic assays were performed submitting Ae. aegypti third-instar larvae to different EMB concentrations (0.0, 0.5, 1.0, 5.0, 10.0, 50.0, and 100.0 µg mL−1) in combination of three different light doses (24.3, 48.6, and 97.2 J cm−2) under either white-light radiation from RGB LEDs or sunlight. The results demonstrated that EMB presented a rapid internalization into the larvae and was phototoxic. The photodynamic action induced 100% of larval mortality after about 40 min of sunlight irradiation even using low EMB concentration (0.5 µg mL−1). The findings reveal EMB as an effective photoactive compound to control larval populations of Ae. aegypti by photodynamic process induced by either sunlight or white-light from RGB LEDs.
Protection of Service-Oriented Environments Serving Critical Infrastructures
Authors: Kyriazis Dimosthenis
Published: August 2018

The emergence of service-oriented architectures has driven the shift towards a service-oriented paradigm, which has been adopted in several application domains. The advent of cloud computing facilities and recently of edge computing environments has increased the aforementioned paradigm shift towards service provisioning. In this context, various “traditional” critical infrastructure components have turned to services, being deployed and managed on top of cloud and edge computing infrastructures. However, the latter poses a specific challenge: the services of the critical infrastructures within and across application verticals/domains (e.g., transportation, health, industrial venues, etc.) need to be continuously available with near-zero downtime. In this context, this paper presents an approach for high-performance monitoring and failure detection of critical infrastructure services that are deployed in virtualized environments. The failure detection framework consists of distributed agents (i.e., monitoring services) to ensure timely collection of monitoring data, while it is enhanced with a voting algorithm to minimize the case of false positives. The goal of the proposed approach is to detect failures in datacenters that support critical infrastructures by targeting both the acquisition of monitoring data in a performant way and the minimization of false positives in terms of potential failure detection. The specific approach is the baseline towards decision making and triggering of actions in runtime to ensure service high availability, given that it provides the required data for decision making on time with high accuracy.
A Differentiated Spatial Assessment of Urban Ecosystem Services Based on Land Use Data in Halle, Germany
Authors: Arnold Janis , Kleemann Janina , Fürst Christine
Published: August 2018

Urban ecosystem services (ES) contribute to the compensation of negative effects caused by cities by means of, for example, reducing air pollution and providing cooling effects during the summer time. In this study, an approach is described that combines the regional biotope and land use data set, hemeroby and the accessibility of open space in order to assess the provision of urban ES. Hemeroby expresses the degree of naturalness of land use types and, therefore, provides a differentiated assessment of urban ES. Assessment of the local capacity to provide urban ES was conducted with a spatially explicit modeling approach in the city of Halle (Saale) in Germany. The following urban ES were assessed: (a) global climate regulation, (b) local climate regulation, (c) air pollution control, (d) water cycle regulation, (e) food production, (f) nature experience and (g) leisure activities. We identified areas with high and low capacity of ES in the urban context. For instance, the central parts of Halle had very low or no capacity to provide ES due to highly compact building styles and soil sealing. In contrast, peri-urban areas had particularly high capacities. The potential provision of regulating services was spatially limited due to the location of land use types that provide these services.
Mechanical Behavior of Liquid Nitrile Rubber-Modified Epoxy Resin under Static and Dynamic Loadings: Experimental and Constitutive Analysis
Authors: Xu Xiao , Gao Shiqiao , Ou Zhuocheng , Ye Haifu
Published: August 2018

Quasi-static and dynamic compression experiments were performed to study the influence of liquid nitrile rubber (LNBR) on the mechanical properties of epoxy resin. The quasi-static experiments were conducted by an electronic universal machine under strain rates of 0.0001/s and 0.001/s, while a Split Hopkinson Pressure Bar (SHPB) system was adopted to perform the dynamic tests for strain rates up to 5600/s. The standard Zhu-Wang-Tang (ZWT) nonlinear viscoelastic model was chosen to predict the elastic behavior of LNBR/epoxy composites under a wide range of strain rates. After some necessary derivation and data fitting, a set of model parameters for the tested materials were finally obtained. Meanwhile, the incremented form of the ZWT nonlinear viscoelastic model were deduced and implemented into the user material program of LS-DYNA. A simulation-test contrast had been performed to verify the validity and feasibility of the algorithm. The results showed that the viscoelastic behavior of epoxy resin can be effectively simulated.
Energy Transfer from Photosystem I to Thermally Reduced Graphene Oxide
Authors: Sulowska Karolina , Wiwatowski Kamil , Szustakiewicz Piotr , Grzelak Justyna , Lewandowski Wiktor , Mackowski Sebastian
Published: August 2018

The energy transfer from photosynthetic complex photosystem I to thermally reduced graphene oxide was studied using fluorescence microscopy and spectroscopy, and compared against the structure in which monolayer epitaxial graphene was used as the energy acceptor. We find that the properties of reduced graphene oxide (rGO) as an energy acceptor is qualitatively similar to that of epitaxial graphene. Fluorescence quenching, which in addition to shortening of fluorescence decay, is a signature of energy transfer varies across rGO substrates and correlates with the transmission pattern. We conclude that the efficiency of the energy transfer depends on the number of rGO layers in the flakes and decreases with this number. Furthermore, careful analysis of fluorescence imaging data confirms that the energy transfer efficiency dependence on the excitation wavelength, also varies with the number of rGO flakes.
Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives
Authors: Vasconcelos Ariana A. , Sucupira Isabela D. , Guedes Alessandra L. , Queiroz Ismael N. , Frattani Flavia S. , Fonseca Roberto J. , Pomin Vitor H.
Published: August 2018

The anticoagulant and antithrombotic properties of three structurally correlated sea urchin-derived 3-linked sulfated α-glycans and their low molecular-weight derivatives were screened comparatively through various in vitro and in vivo methods. These methods include activated partial thromboplastin time, the inhibitory activity of antithrombin over thrombin and factor Xa, venous antithrombosis, the inhibition of platelet aggregation, the activation of factor XII, and bleeding. While the 2-sulfated fucan from Strongylocentrotus franciscanus was observed to be poorly active in most assays, the 4-sulfated fucan from Lytechinus variegatus, the 2-sulfated galactan from Echinometra lucunter and their derivatives showed multiple effects. All marine compounds showed no capacity to activate factor XII and similar low bleeding tendencies regardless of the dose concentrations used to achieve the highest antithrombotic effect observed. The 2-sulfated galactan showed the best combination of results. Our work improves the background about the structure-function relationship of the marine sulfated glycans in anticoagulation and antithrombosis. Besides confirming the negative effect of the 2-sulfated fucose and the positive effect of the 2-sulfated galactose on anticoagulation in vitro, our results also demonstrate the importance of this set of structural requirements on antithrombosis in vivo, and further support the involvement of high-molecular weight and 4-sulfated fucose in both activities.
Photosensitive Organic-Inorganic Hybrid Materials for Room Temperature Gas Sensor Applications
Authors: Rumyantseva Marina , Nasriddinov Abulkosim , Vladimirova Svetlana , Tokarev Sergey , Fedorova Olga , Krylov Ivan , Drozdov Konstantin , Baranchikov Alexander , Gaskov Alexander
Published: August 2018

In this work, the hybrids based on nanocrystalline SnO2 or In2O3 semiconductor matrixes and heterocyclic Ru(II) complex are studied as materials for gas sensors operating at room temperature under photoactivation with visible light. Nanocrystalline semiconductor oxides are obtained by chemical precipitation with subsequent thermal annealing and characterized by XRD, SEM and single-point BET methods. The heterocyclic Ru(II) complex is synthesized for the first time and investigated by 1H NMR, 13C NMR APT, MALDI-MS analysis, and UV-Vis spectroscopy. The HOMO and LUMO energies of the Ru(II) complex are calculated from cyclic voltammetry data. The hybrid materials are characterized by TGA-MS analysis and EDX mapping. The optical properties of hybrids are studied by UV-Vis spectroscopy in the diffuse reflection mode. The investigation of spectral dependencies of photoconductivity of hybrid samples demonstrates that the role of organic dye consists in shifting the photosensitivity range towards longer wavelengths. Sensor measurements demonstrate that hybrid materials are able to detect NO2 in the concentration range of 0.25–2 ppm without the use of thermal heating under periodic illumination with even low-energy long-wavelength (red) light.
Charge Transport in Trap-Sensitized Infrared PbS Quantum-Dot-Based Photoconductors: Pros and Cons
Authors: Maulu Alberto , Navarro-Arenas Juan , Rodríguez-Cantó Pedro J. , Sánchez-Royo Juan F. , Abargues Rafael , Suárez Isaac , Martínez-Pastor Juan P.
Published: August 2018

Control of quantum-dot (QD) surface chemistry offers a direct approach for the tuning of charge-carrier dynamics in photoconductors based on strongly coupled QD solids. We investigate the effects of altering the surface chemistry of PbS QDs in such QD solids via ligand exchange using 3-mercaptopropionic acid (MPA) and tetrabutylammonium iodide (TBAI). The roll-to-roll compatible doctor-blade technique was used for the fabrication of the QD solid films as the photoactive component in photoconductors and field-effect phototransistors. The ligand exchange of the QD solid film with MPA yields superior device performance with higher photosensitivity and detectivity, which is due to less dark current and lower noise level as compared to ligand exchange with TBAI. In both cases, the mechanism responsible for photoconductivity is related to trap sensitization of the QD solid, in which traps are responsible of high photoconductive gain values, but slow response times under very low incident optical power (<1 pW). At medium–high incident optical powers (>100 pW), where traps are filled, both MPA- and TBAI-treated photodevices exhibit similar behavior, characterized by lower responsivity and faster response time, as limited by the mobility in the QD solid.
Lutein Intake and Blood Lutein Concentration Are Positively Associated with Physical Activity in Adults: A Systematic Review
Authors: Cooke Madeline C. , Coates Alison M. , Buckley Elizabeth S. , Buckley Jonathan D.
Published: August 2018

Lutein is a carotenoid that reduces the risk of some chronic diseases, possibly by altering physical activity behavior. The objective of this study was to conduct a systematic review of studies examining the relationship between lutein status (dietary intake/blood concentration) and physical activity. Peer-reviewed studies published in Medline, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and Embase were included if they reported a measure of association between lutein status and physical activity. Seventeen studies met the inclusion criteria. Eleven reported positive associations, three reported mixed results, and three reported no association. Two studies used objective measures of lutein status (blood concentration) and physical activity (accelerometry) and reported positive associations, with correlations of ≥0.36 and differences of ≥57% in physical activity between upper and lower tertiles. Studies using self-report measures reported weaker correlations (r = 0.06 to 0.25), but still more physical activity (18% to ≥600% higher) in those with the highest compared with the lowest lutein status. Higher lutein status may be associated with higher levels of physical activity, which may contribute to a reduced risk of chronic disease.
Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol
Authors: Cho Pil Joung , Paudel Sanjita , Lee Doohyun , Jin Yun Ji , Jo GeunHyung , Jeong Tae Cheon , Lee Sangkyu , Lee Taeho
Published: August 2018

Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously. The metabolic pathway of osthenol was partially confirmed in rat osthole studies, and 11 metabolic products were identified in rat urine. However, the metabolic pathway of osthenol in human liver microsomes (HLM) has not been reported. In this study, we elucidated the structure of generated metabolites using a high-resolution quadrupole-orbitrap mass spectrometer (HR-MS/MS) and characterized the major human cytochrome P450 (CYP) and uridine 5′-diphospho-glucuronosyltransferase (UGT) isozymes involved in osthenol metabolism in human liver microsomes (HLMs). We identified seven metabolites (M1-M7) in HLMs after incubation in the presence of nicotinamide adenine dinucleotide phosphate (NADPH) and uridine 5′-diphosphoglucuronic acid (UDPGA). As a result, we demonstrated that osthenol is metabolized to five mono-hydroxyl metabolites (M1-M5) by CYP2D6, 1A2, and 3A4, respectively, a 7-O-glucuronide conjugate (M6) by UGT1A9, and a hydroxyl-glucuronide (M7) from M5 by UGT1A3 in HLMs. We also found that glucuronidation is the dominant metabolic pathway of osthenol in HLMs.
Adsorption Separation of Analgesic Pharmaceuticals from Ultrapure and Waste Water: Batch Studies Using a Polymeric Resin and an Activated Carbon
Authors: Coimbra Ricardo N. , Escapa Carla , Otero Marta
Published: August 2018

The performance of a polymeric resin (Sepabeads SP207, from Resindion, Binasco, Italy) was compared with that of an activated carbon (GPP20, from Chemviron Carbon, Feluy, Belgium) in the adsorption of acetaminophen and ibuprofen from either ultrapure or waste water. Kinetic and equilibrium adsorption experiments were carried out under batch operation conditions, and fittings of the obtained results to different models were determined. The kinetic experimental results fitted the pseudo-first and -second order equations, and the corresponding kinetic rates evidenced that the pharmaceuticals adsorption was faster onto GPP20 than onto Sepabeads SP207, but was mostly unaffected by the aqueous matrix. The equilibrium results fitted the Langmuir-Freundlich isotherm model. The corresponding maximum adsorption capacity (Qm, mg−1) was larger onto GPP20 (202 mg g−1 ≤ Qm ≤ 273 mg g−1) than onto the polymeric resin (7 mg g−1 ≤ Qm ≤ 18 mg g−1). With respect to the parameter KLF (mg g−1 (mg L−1)−1/n), which points to the adsorbent-adsorbate affinity, greater values were determined for the pharmaceuticals adsorption onto GPP20 than onto Sepabeads SP207. For both adsorbents and pharmaceuticals, neither Qm or KLF were affected by the aqueous matrix.
Preparation of Polypropylene Micro and Nanofibers by Electrostatic-Assisted Melt Blown and Their Application
Authors: Pu Yi , Zheng Jie , Chen Fuxing , Long Yunze , Wu Han , Li Qiusheng , Yu Shuxin , Wang Xiaoxiong , Ning Xin
Published: August 2018

In this paper, a novel electrostatic-assisted melt blown process was reported to produce polypropylene (PP) microfibers with a diameter as fine as 600 nm. The morphology, web structure, pore size distribution, filtration efficiency, and the stress and strain behavior of the PP nonwoven fabric thus prepared were characterized. By introducing an electrostatic field into the conventional melt-blown apparatus, the average diameter of the melt-blown fibers was reduced from 1.69 to 0.96 μm with the experimental setup, and the distribution of fiber diameters was narrower, which resulted in a filter medium with smaller average pore size and improved filtration efficiency. The polymer microfibers prepared by this electrostatic-assisted melt blown method may be adapted in a continuous melt blown process for the production of filtration media used in air filters, dust masks, and so on.
Benefits of the Successive GPM Based Satellite Precipitation Estimates IMERG–V03, –V04, –V05 and GSMaP–V06, –V07 Over Diverse Geomorphic and Meteorological Regions of Pakistan
Authors: Satgé Frédéric , Hussain Yawar , Bonnet Marie-Paule , Hussain Babar M. , Martinez-Carvajal Hernan , Akhter Gulraiz , Uagoda Rogério
Published: August 2018

Launched in 2014, the Global Precipitation Measurement (GPM) mission aimed at ensuring the continuity with the Tropical Rainfall Measuring Mission (TRMM) launched in 1997 that has provided unprecedented accuracy in Satellite Precipitation Estimates (SPEs) on the near-global scale. Since then, various SPE versions have been successively made available from the GPM mission. The present study assesses the potential benefits of the successive GPM based SPEs product versions that include the Integrated Multi–Satellite Retrievals for GPM (IMERG) version 3 to 5 (–v03, –v04, –v05) and the Global Satellite Mapping of Precipitation (GSMaP) version 6 to 7 (–v06, –v07). Additionally, the most effective TRMM based SPEs products are also considered to provide a first insight into the GPM effectiveness in ensuring TRMM continuity. The analysis is conducted over different geomorphic and meteorological regions of Pakistan while using 88 precipitations gauges as the reference. Results show a clear enhancement in precipitation estimates that were derived from the very last IMERG–v05 in comparison to its two previous versions IMERG–v03 and –v04. Interestingly, based on the considered statistical metrics, IMERG–v03 provides more consistent precipitation estimate than IMERG–v04, which should be considered as a transition IMERG version. As expected, GSMaP–v07 precipitation estimates are more accurate than the previous GSMaP–v06. However, the enhancement from the old to the new version is very low. More generally, the transition from TRMM to GPM is successful with an overall better performance of GPM based SPEs than TRMM ones. Finally, all of the considered SPEs have presented a strong spatial variability in terms of accuracy with none of them outperforming the others, for all of the gauges locations over the considered regions.
Simultaneous Ship Detection and Orientation Estimation in SAR Images Based on Attention Module and Angle Regression
Authors: Wang Jizhou , Lu Changhua , Jiang Weiwei
Published: August 2018

Ship detection and angle estimation in SAR images play an important role in marine surveillance. Previous works have detected ships first and estimated their orientations second. This is time-consuming and tedious. In order to solve the problems above, we attempt to combine these two tasks using a convolutional neural network so that ships may be detected and their orientations estimated simultaneously. The proposed method is based on the original SSD (Single Shot Detector), but using a rotatable bounding box. This method can learn and predict the class, location, and angle information of ships using only one forward computation. The generated oriented bounding box is much tighter than the traditional bounding box and is robust to background disturbances. We develop a semantic aggregation method which fuses features in a top-down way. This method can provide abundant location and semantic information, which is helpful for classification and location. We adopt the attention module for the six prediction layers. It can adaptively select meaningful features and neglect weak ones. This is helpful for detecting small ships. Multi-orientation anchors are designed with different sizes, aspect ratios, and orientations. These can consider both speed and accuracy. Angular regression is embedded into the existing bounding box regression module, and thus the angle prediction is output with the position and score, without requiring too many extra computations. The loss function with angular regression is used for optimizing the model. AAP (average angle precision) is used for evaluating the performance. The experiments on the dataset demonstrate the effectiveness of our method.
Features of Invariant Extended Kalman Filter Applied to Unmanned Aerial Vehicle Navigation
Authors: Ko Nak Yong , Youn Wonkeun , Choi In Ho , Song Gyeongsub , Kim Tae Sik
Published: August 2018

This research used an invariant extended Kalman filter (IEKF) for the navigation of an unmanned aerial vehicle (UAV), and compared the properties and performance of this IEKF with those of an open-source navigation method based on an extended Kalman filter (EKF). The IEKF is a fairly new variant of the EKF, and its properties have been verified theoretically and through simulations and experiments. This study investigated its performance using a practical implementation and examined its distinctive features compared to the previous EKF-based approach. The test used two different types of UAVs: rotary wing and fixed wing. The method uses sensor measurements of the location and velocity from a GPS receiver; the acceleration, angular rate, and magnetic field from a microelectromechanical system-attitude heading reference system (MEMS-AHRS); and the altitude from a barometric sensor. Through flight tests, the estimated state variables and internal parameters such as the Kalman gain, state error covariance, and measurement innovation for the IEKF method and EKF-based method were compared. The estimated states and internal parameters showed that the IEKF method was more stable and convergent than the EKF-based method, although the estimated locations, velocities, and altitudes of the two methods were comparable.
On the Feasibility of Using an Ear-EEG to Develop an Endogenous Brain-Computer Interface
Authors: Choi Soo-In , Han Chang-Hee , Choi Ga-Young , Shin Jaeyoung , Song Kwang Soup , Im Chang-Hwan , Hwang Han-Jeong
Published: August 2018

Brain-computer interface (BCI) studies based on electroencephalography (EEG) measured around the ears (ear-EEGs) have mostly used exogenous paradigms involving brain activity evoked by external stimuli. The objective of this study is to investigate the feasibility of ear-EEGs for development of an endogenous BCI system that uses self-modulated brain activity. We performed preliminary and main experiments where EEGs were measured on the scalp and behind the ears to check the reliability of ear-EEGs as compared to scalp-EEGs. In the preliminary and main experiments, subjects performed eyes-open and eyes-closed tasks, and they performed mental arithmetic (MA) and light cognitive (LC) tasks, respectively. For data analysis, the brain area was divided into four regions of interest (ROIs) (i.e., frontal, central, occipital, and ear area). The preliminary experiment showed that the degree of alpha activity increase of the ear area with eyes closed is comparable to those of other ROIs (occipital > ear > central > frontal). In the main experiment, similar event-related (de)synchronization (ERD/ERS) patterns were observed between the four ROIs during MA and LC, and all ROIs showed the mean classification accuracies above 70% required for effective binary communication (MA vs. LC) (occipital = ear = central = frontal). From the results, we demonstrated that ear-EEG can be used to develop an endogenous BCI system based on cognitive tasks without external stimuli, which allows the usability of ear-EEGs to be extended.
Difference DV_Distance Localization Algorithm Using Correction Coefficients of Unknown Nodes
Authors: Sun Lijun , Chen Tianfei
Published: August 2018

Node localization is an essential requirement in the increasing prevalence of wireless sensor networks applications. As the most commonly used localization algorithm, the DV_Distance algorithm is more sensitive to ranging error, and also has lower localization accuracy. Therefore, this paper proposes a novel difference DV_Distance localization algorithm using correction coefficients of unknown nodes. Taking account of the fact that correction coefficients of unknown nodes should be different, the proposed method has employed the correction model based on unknown nodes. Some correction coefficients for different direction anchor nodes can be indirectly calculated using the known difference of actual Euclidean distance and corresponding accumulated hop distance between anchor nodes, and then the weighting factors for the correction coefficients of different direction anchor nodes are also computed according to their actual contribution degree, so as to make sure that the corrected distances from unknown nodes to anchor nodes, modified by the final correction coefficient, are closer to the actual distances. At last, the positions of unknown nodes can be calculated using multilateral distance measurement. The simulation results demonstrate that the proposed approach is a localization algorithm with easier implementation, and it not only has better performance on localization accuracy than existing DV_Distance localization algorithm, but also improves the localization stability under the same experimental conditions.
A Novel Acoustic Filtering Sensor for Real-Time Tension Monitoring of Hoist Wire Ropes
Authors: Zhang Xiaoguang , Song Zhenyue , Da Jianpu , Fu Jianbao
Published: August 2018

The real-time tension monitoring of wire ropes is a universal way to judge whether the hoist is overloaded in the special working environment of the coal mine. However, due to the strong drafts, unevenness of guide and flexible vibration of wire ropes, it is a challenge to monitor the tension with high accuracy. For this purpose, a new type of acoustic filtering sensor is designed in this study. To adapt to the violent vibration during the monitoring process, a structure with a cylindrical cavity and a narrow gap is designed in the sensor. The coupling between the internal fluid and sensor structure can greatly absorb the vibration energy. With the view of optimizing the filtering performance of the sensor, the influences on the filtering characteristics are presented and analyzed through employing different structural and acoustic parameters in simulations. Finally, acoustic filtering sensor prototypes based on optimized parameters are calibrated and tested in a real coal mine. The results have revealed that our acoustic filtering sensor can not only address the deficiencies of current pressure sensors in coal mining and achieve tension monitoring in real-time, but is also able to diagnose and forecast the occurrence of tension imbalance accidents.
Fully Bayesian Prediction Algorithms for Mobile Robotic Sensors under Uncertain Localization Using Gaussian Markov Random Fields
Authors: Jadaliha Mahdi , Jeong Jinho , Xu Yunfei , Choi Jongeun , Kim Junghoon
Published: August 2018

In this paper, we present algorithms for predicting a spatio-temporal random field measured by mobile robotic sensors under uncertainties in localization and measurements. The spatio-temporal field of interest is modeled by a sum of a time-varying mean function and a Gaussian Markov random field (GMRF) with unknown hyperparameters. We first derive the exact Bayesian solution to the problem of computing the predictive inference of the random field, taking into account observations, uncertain hyperparameters, measurement noise, and uncertain localization in a fully Bayesian point of view. We show that the exact solution for uncertain localization is not scalable as the number of observations increases. To cope with this exponentially increasing complexity and to be usable for mobile sensor networks with limited resources, we propose a scalable approximation with a controllable trade-off between approximation error and complexity to the exact solution. The effectiveness of the proposed algorithms is demonstrated by simulation and experimental results.
The Study of the Structure—Diuretic Activity Relationship in a Series of New N-(Arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo-[3,2,1-ij]quinoline-5-carboxamides
Authors: Ukrainets Igor V. , Golik Mykola Y. , Sidorenko Lyudmila V. , Korniyenko Valentina I. , Grinevich Lina A. , Sim Galina , Kryvanych Olga V.
Published: August 2018

In accordance with the principles of “me-too” technique, the preparative method for obtaining has been proposed, and the synthesis of a large series of new N-(arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamides as structurally close analogs of tricyclic pyrrolo- and pyridoquinoline diuretics has been carried out. All target compounds were obtained with high yields and purity by amidation of ethyl ester of the corresponding 2-methyl-pyrroloquinoline-5-carboxylic acid with arylalkylamines in boiling ethanol. Their structure was confirmed by the data of elemental analysis, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and polarimetry. Moreover, interpretations of their 1H and 13C-NMR spectra, their mass spectrometric behavior, as well as peculiarities of the polarimetric studies were discussed. The effect of N-(arylalkyl)-6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxamides on the urinary function of the kidneys was studied in white rats by the standard method of oral administration in the dose of 10 mg/kg compared to hydrochlorothiazide. According to the results of the primary pharmacological screening, the structural and biological regularities that were unexpected, but interesting for further studies were revealed. Among the substances studied, the samples, which by their diuretic effect are not inferior and even superior to both the known hydrochlorothiazide and the lead structure of the pyrroloquinoline group, have been found. On this basis, it can be argued that the introduction of the methyl group made by us in position 2 of pyrrolo[3,2,1-ij]quinoline nucleus can be considered as a successful and promising implementation of the “me-too” cloning of tricyclic 4-hydroxyquinoline-2-one diuretics.
Young Europeans: A New Political Generation?
Authors: Ross Alistair
Published: August 2018

Young people in Europe are often described as apolitical non-participants in the civic culture of their own states and the European Union (EU). Using empirical data based on group discussions (n = 324) in 29 European states (104 locations; 2000 young people aged between 11 and 19), this paper challenges this, and suggests that many young people have distinct political views and are motivated to participate in both political discussions and traditional and non-traditional forms of participation. They are particularly interested in a range of current issues, largely around human rights, migration and (anti-)nationalism, and the article illustrates this with examples from a range of countries. Human rights issues raised concerned their perception of contemporary injustices, which were constructed as European values and formed a significant element in their self-identification as Europeans, and a general unwillingness to be identified with ‘the nation’. This broad pan-European analysis suggests that young people see themselves in many ways as a politically distinct cohort, a generation with different political values than those of their parents and grandparents.
Disability Status, Housing Tenure, and Residential Attainment in Metropolitan America
Authors: Friedman Samantha , Hamer-Small Kaya , Choudary Wendie
Published: August 2018

In 2010, 18.7 percent of the U.S. non-institutionalized population had a disability. Despite the existence of the Fair Housing Amendments Act (FHAA), which prohibits housing discrimination on the basis of disability, recent research has found that individuals and/or families with disabilities live in poorer quality housing and neighborhoods than those without disabilities. However, no research has examined such disparities in residential attainment separately by housing tenure; our research seeks to fill this gap. The findings suggest that residential disadvantage among households with people with disabilities is worse in the sales market compared to the rental market. These findings are discussed as they relate to theories on residential attainment. The implications of our study suggest that more attention should be given to people with disabilities as they navigate the housing market, particularly in the sales market, and that greater enforcement of the FHAA is warranted in the sales market.
The Valorization of Ammonia in Manure Digestate by Means of Alternative Stripping Reactors
Authors: Baldi Marco , Collivignarelli Maria Cristina , Abbà Alessandro , Benigna Ilaria
Published: August 2018

The proper recovery of resources such as nitrogen and phosphorus present in the manure from intensive livestock farming is essential in order to allow environmental sustainable zootechny especially in densely populated areas where these activities are historically prevalent. The experiences at full-scale established that the ammonia stripping allows recovery from 35% to 50% of nitrogen depending on the type of substrate treated with anaerobic digestion and on the nitrogen content/form in the digestate. This study focuses on the ammonia stripping on digestate derived from anaerobic digestion of livestock manure and corn silage. Two different full-scale plants are studied including a packed column and an air bubble reactor without filling material with the aim to reduce fouling issues due to the content of suspended solids in digestate. The main results suggest that the use of an air bubble reactor could treat digestate with high concentration of suspended solids. A deeper study based on a two-level factorial experiment highlights that the temperature is an important parameter that influences the ammonia removal yields. Thus, a proper management of available thermal energy is very important.
Proposing a Value-Based Digital Government Model: Toward Broadening Sustainability and Public Participation
Authors: Lee Jungwoo , Kim Byoung Joon , Park SeonJu , Park Sungbum , Oh Kangtak
Published: August 2018

It has generally been well-established, by a number of studies, that the rapid advance and global diffusion of information and communication technology (ICT) is impacting the milieu of governance along with a socio-technical transformation of society at all levels. With a growing interest in digital government, the inquiry concerning a common digital model has been raised. To assist public administrators in thinking about new digital government for their organizations, a new developmental model framework is proposed in this article. This model is drawn from value-based analysis contained in developmental policies, and a subsequent policy development process is also proposed. In doing so, the new model would represent accelerated socio-technical transformation with intelligent technologies, escalating wicked problems appearing despite technological advances. The limitations of the current finite state model are also discussed.
Impacts of Financial Inclusion on Non-Performing Loans of Commercial Banks: Evidence from China
Authors: Chen Feng-Wen , Feng Yuan , Wang Wei
Published: August 2018

Non-performing loans of commercial banks have long hampered the development of the banking sector, and directly reflect the credit risk and asset quality. With the continuous development of the financial industry, the introduction of financial inclusion has greatly eased the shortage of funds, and narrowed the gap between poor and rich. However, whether the promotion of financial inclusion in the financial industry could affect the non-performing loans of commercial banks has not been verified. Therefore, this paper discusses the possible associations between financial inclusion and non-performing loans of commercial banks on the regional level, constructs a panel data model by selecting the data of 31 provinces (including 4 municipalities) in China from 2005 to 2016, and uses the fixed effect model for empirical test. The empirical results (from an overall national sample) reveal a negative impact of the financial inclusion on non-performing loans. Moreover, the development of the banking sector and the regional consumption could enhance the impact of financial inclusion, while government intervention and unemployment could reduce the impact of financial inclusion. From the analysis of the regional sample, when the development of financial inclusion reaches a high level, the lagged financial inclusion promote the non-performing loans of commercial banks; however, when the financial inclusion is underdeveloped, the development of commercial banks act as a disincentive to non-performing loans. Therefore, the local governments should pay more attention to the influences of financial inclusion on the financial industry, in order to maintain the stability of banking asset quality. In addition, the negative impact of financial inclusion on non-performing loans of commercial banks is significant in China central region, while its impacts in China eastern and western regions are not significant. This indicates that the development of the financial industry and economy can hamper the effects of financial inclusion. It is necessary to adjust the financial resource allocation according to the characteristics of different regions in China, so that the financial inclusion can effectively promote the regional financial industry upgrade, improve regional capital flow efficiency, and fundamentally reduce the non-performing loans of commercial banks. According to the sample analysis by time, there is a significant negative impact relationship between inclusive finance and commercial banks’ non-performing loans after the financial crisis, while the impacts before and during the financial crisis are not significant. This demonstrates that the impact of the global financial crisis on China’s regional economy has further enhanced the inefficiency of the inclusive financial system on credit risk, which in turn, helps commercial banks better maintain asset quality stability.