bluuebunny/crossref_metadata_2025 huggingface dataset:
Alberoni y el gobierno de la Monarquía española
Authors: Martínez Navas Isabel
Published: April 2019

Entre 1717 y 1719 Felipe V contó con un "Ministro principal", Giulio Alberoni. La difusa naturaleza del poder ejercido por este Ministro, hace necesario el establecimiento de contornos precisos -cronológicos, institucionales y, en alguna medida también, materiales- a su intervención en el gobierno de la Monarquía española.
Jornada en conmemoración del 30º aniversario de la Ley Orgánica General Penitenciaria
Authors: Ruidiaz García Carmen
Published: April 2019

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Un apunte crítico sobre la responsabilidad social corporativa (RSC/RSE)
Authors: Ruiz Muñoz Miguel
Published: April 2019

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Delación forzosa, preterición y legítima asistencial: análisis en los ordenamientos cubano y español (II)
Authors: Alfaro Guillén Yanet
Published: April 2019

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Temeridad y malicia procesales al banquillo: crónica de dos lacras jurídicas que retenden consolidarse
Authors: Torres Manrique Jorge Isaac
Published: April 2019

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Prueba de elasticidad del concepto «ciudadanía».Comentarios al libro Donaldson, Sue y Kymlicka, Will, Zoopolis. A Political Theory of Animal Rights, Oxford University Press, Nueva York, 2011, 329 págs.
Authors: San Martín Segura David
Published: April 2019

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El derecho a las relaciones personales entre los nietos y sus abuelos. Una aproximación socio-jurídica
Authors: Gracia Ibáñez Jorge
Published: April 2019

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Semblanza de Miguel Servet, reformador y defensor de la libertad de conciencia
Authors: Martínez de Pisón Cavero José María
Published: April 2019

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El manantial de las víctimas. Una lectura desde la Victimología de «El manantial de la doncella» (Jungfrukällan, 1960) de Ingmar Bergman.
Authors: Gracia Ibáñez Jorge
Published: April 2019

En este texto proponemos una guía de lectura, a partir de la Victimología, de la película «El manantial de la doncella» (Jungfrukällan, 1960) dirigida por Ingmar Bergman. Se analizan, en primer lugar, las características de la obra que la convierten en un material docente óptimo para la enseñanza universitaria de la Victimología. En segundo lugar se realiza una síntesis crítica de la emergencia de la victimología como disciplina científica y del proceso de redescubrimiento de las víctimas en el Derecho penal y la justicia criminal analizando algunas de sus paradojas y contradicciones. En tercer y último lugar se aborda el análisis concreto de algunos temas presentes o sugeridos por la película en una lectura en clave victimológica conectándolos con tres emociones: la compasión, el deseo de venganza y el sentimiento de pérdida.
Argumentos de Derecho comparado para extenderlas tasas judiciales al orden social
Authors: Liébana Ortiz Juan Ramón
Published: April 2019

El presente trabajo analiza la semejanza de la regulación legal de las tasas judiciales en los ordenamientos jurídicos español e inglés, con especial referencia al orden jurisdiccional laboral, teniendo como referencia fundamental los pronunciamientos del Tribunal Europeo de Derechos Humanos y el Tribunal de Justicia de la Unión Europea. El trabajo constata que enfrentan las mismas críticas desde al menos el siglo XVIII, y que los pronunciamientos jurisdiccionales nacionales son también muy similares. Utilizando argumentos de Derecho comparado, el trabajo concluye con una defensa de las ventajas de extender las tasas judiciales al orden jurisdiccional social.
Yo, Robot: de la biología a la singularidad. ¿Nuevas preguntas para la Filosofía del Derecho?
Authors: Martínez de Pisón Cavero José María
Published: April 2019

La evolución científica y el progreso de la sociedad han ido siempre acompañadas de un replanteamiento de las categorías jurídicas y políticas sobre las que se fundamenta. En la actualidad, se está anticipando una nueva revolución tecnológica, impulsada por los avances en la genética, la robótica y la nanotecnología. De modo invariable, esta nueva transformación de la humanidad está implicando una nueva revisión de dichas categorías. La ciencia ficción, en el cine –con películas como Yo, robot–, en la literatura, en las series de TV, ya están exponiendo un nuevo relato del futuro y, por tanto, un nuevo significado de esos conceptos. ¿Podrá la reflexión iusfilosófica adaptarse a estos nuevos tiempos y anticipar e, incluso, orientar y encauzar el debate del siglo XXI?
Presentación
Authors: Susín Betrán Raúl
Published: April 2019

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El valor educativo de la Constitución
Authors: Muñoz Arnau Juan Andrés
Published: April 2019

La Constitución española tiene un valor educativo que puede deducirse de la totalidad de su articulado. Ofrece una imagen de la persona que puede deducirse principalmente del principio de dignidad humana y de los derechos fundamentales y proclama el libre desarrollo de la personalidad, que en lo que se refiere a la educación se convierte en desarrollo pleno, con lo que establece el fundamento y el fin de la educación. Los principios democráticos de convivencia se constituyen en valores que deben informar la actividad educativa. La misma estructura del derecho positivo puede servir de imagen para el comportamiento de la persona.
A clinical study of hyperreactive airway disease with wheeze in children aged five to twelve years with special reference to pulmonary function test
Authors: Reddy Arjun , Patel Abhishek , Chetty Sanjeev
Published: April 2019

Background: Pulmonary function test is the easiest and most cost-effective method to evaluate respiratory functions. PFT can be measured by a simple instrument spirometer. Measuring PFT has been suggested as an important tool in understanding HRAD and its complications and management by all international guidelines.  The objectives of this study were to clinically diagnose the hyperreactive airway disease in children coming to Navodaya Medical College, Raichur, of age group 5 to 12 years. And to perform pulmonary function test before and after the use of a bronchodilator.Methods: PFT was measured in 100 children who came with HRAD with wheeze using Spiro lab III spirometer. The child was given then nebulization with salbutamol and PFT was performed again after 30 min.Results: A total of 100 clinically diagnosed cases of HRAD of age group 5 to 12 years of both the gender was taken into the study, of which more than 44% of the children showed more than 20% improvement in parameters FEV1, PEF, FVC and marginal improvement in EV1/FVC post bronchodilator compared to their prebronchodilator parameters. The young children of both the gender showed better improvement than elder children.Conclusions: Spirometry is the best tool to assess HRAD even in younger children, early diagnosis and regular follow up with PFT helps to understand and prevent the progression of the disease with prompt treatment.
O PERSONALISMO: UMA RE-LEITURA DO PENSAMENTO FILOSÓFICO DE MOUNIER
Authors: Ribeiro João Francisco Cócaro , Junges Fábio César
Published: April 2019

O presente texto tem como escopo realizar uma re-leitura a partir do pensamento filosófico de Emmanuel Mounier imbricado, principalmente, na obra O Personalismo. A admoestação de Mounier tem ênfase na liberdade da pessoa humana, a qual a presente analítica investigará, auscultando também as diversas concepções e interpretações da mesma ao longo da história e da tradição.
Фейковая экономика: истина где-то рядом
Authors: Степанова Татьяна Евгеньевна , Манохина Надежда Васильевна
Published: April 2019

В статье раскрывается феномен современной экономики, которую называют фейковой, экономикой намеренного обмана. Авторы, признавая правомерность данного подхода и исследуя фейк–индустрию как реально существующий сектор экономики, обосновывают собственную научную позицию и считают фейковую экономику экономикой непреднамеренного искажения, это другая, более глубинная ее сторона, обусловленная объективными причинами и факторами - информационной асимметрией, доминантой интернета как источника получения данных в современном мире, экспоненциальным увеличением информации и ее неоднородным рассредоточением между различными субъектами, асимметрией знаний и ограниченностью и дифференциацией когнитивных способностей субъектов. В качестве прогноза авторы рассматривают расширение пространства фейковой экономики, поскольку это выгодно определенным субъектам во всех странах, включая и Россию.
Prevalence of new-onset migraine in patients with idiopathic intracranial hypertension in comparison to the general population
Authors: Togha Mansoureh , Shirbache Kamran , Rahmanzadeh Reza , Ghorbani Zeinab , Yari Zahra , Refaeian Farshid , Behbahani Shirin , Panahi Parsa
Published: April 2019

Background: Idiopathic intracranial hypertension (IIH) encompasses patients with elevated intracranial pressure (ICP). Generally, it is difficult to make a differential diagnosis between IIH and co-existing migraine headaches. Thus, this article intends to estimate the prevalence of migraine in patients with IIH and explain the occurrence of new-onset migraine after the diagnosis of IIH. 
Methods: The case group included 108 patients with IIH referred to the neurology wards of three university hospitals. A random sample of controls (n = 103) were recruited from patients hospitalized in the surgery and orthopedics ward. A checklist for migraine diagnosis was filled out. Cerebrospinal fluid (CSF) pressure and presence or absence of papilloedema (PE) in the patients and any necessary data were also recorded from the inpatient medical documents. All statistical analyses were done by SPSS software.
Results: There were 70 (64.80%) and 22 (21.40%) migraineurs in the case and control groups, respectively, and the difference was found to be 
significant (P < 0.001). In 26 (37.14%) migraine cases in the IIH group, the disorder was diagnosed after developing IIH. Also, there was a past medical history of having migraine in 44 (62.85%) migraineurs. In the fully adjusted regression models, the odds of being affected by migraine in patients with IIH was 6.17 times greater than the controls [odds ratio (OR) = 7.15, 95% confidence interval (CI) = 3.56-14.36, P < 0.010]. The patients’ mean CSF opening pressure was 32.10 ± 1.03 cmH2O and 93 (81.60%) subjects were found to have PE.
Conclusion: It was demonstrated that subjects with IIH might have about a 6-time higher likelihood of developing migraine headache than the general population. These considerations can help prevent misdiagnosis of migraine headache as the recurrence of IIH or uncontrolled IIH and subsequent inappropriate management.
portrayal of a young woman in 16th century Islamic art: Does she have anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis?
Authors: Kondziella Daniel , Bech Sara
Published: April 2019

Abstract not available.
longitudinally extensive myelitis as first presentation of renal cell carcinoma
Authors: Ansari Behnaz , Okhovat Ali Asghar , Ashtari Fereshteh
Published: April 2019

Abstract not available.
A Systematic Review: Impact of Caesarean Rate after Implementation of Robson’s Criteria at Secondary and Tertiary Hospital
Authors: Octavianty P
Published: April 2019

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Analysis of Compliance Appendectomy Integrated Care Pathway (ICP) and Evaluation of Its Implementation at Awal Bros Batam Hospital Year 2016
Authors: Sari Suciati S , Yulianty Permanasari V
Published: April 2019

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Internal Factors Approach to Improve Hospital Nurse Performance in Developing Countries: Systematic Review
Authors: Zefrial Y
Published: April 2019

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The Importance of Implementation of Hand Hygiene Practice in Reducing Healthcare-associated Infections: A Systematic Review
Authors: Andriani Y , Nadjib M
Published: April 2019

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Work Stress Among Nurses in a Private Hospital in Lumajang Indonesia
Authors: Dewanto A
Published: April 2019

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Compliance of the Nurse for Fall Risk Assessment as a Procedure of Patient Safety: A Systematic Review
Authors: Nadia P , Yulianty Permanasari V
Published: April 2019

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Analyzing Patient Education Methods to Improve Patient Care in Hospital: A Systematic Review
Authors: Ridwan Hasyim M A , Junadi P
Published: April 2019

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Occurrence and Preventability of Adverse Drug Events in Hospitalized Patients: A Systematic Review
Authors: . Suherman , Nurwahyuni A
Published: April 2019

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石油机械中O形密封圈的动密封特性分析
Authors: 浩瀚 薛
Published: April 2019

随着我国社会经济的发展，我国石油机械行业也在随之不断的发生改变，近年来，随着我国针对石油机械行业研究的不断深入，虽然已经能够在基础环节满足时代发展对石油机械的需求，但是，就目前来说针对O形密封圈的动密特性分析仍旧相对较少，这种情况的存在不仅仅会使得在实际的石油机械运行环节密封情况存在一定的恶劣影响同时影响实际的运行，由此，本文通过对以往石油机械运行问题进行研究，构建了O形密封圈有限元的模式，分析其中可能存在的问题并针对其影响因素进行研究，从而以期能够在一定程度上帮助我国未来的石油机械行业发展。
千米深井长距离贯通测量技术与实践
Authors: 燕 钟
Published: April 2019

本文说明了千米深井长距离贯通测量的具体做法，基本要求和确保精准贯通的一些技术措施。
Book reviews
Authors: Stewart Michelle , Frigerio Gill
Published: April 2019

Creative Career Coaching: Theory into practice by Liane Hambly and Ciara Bomford;  
The Career Coaching Toolkit by Julia Yates; 
Career Guidance for Social Justice: Contesting Neoliberalism, edited by T. Hooley, R.G. Sultana and R. Thomsen.
Performance Comparing and Analysis for Slot Allocation Model
Authors: Ye ZhiJian , Li YanWei , Bai JingTing , Zheng Xinxin
Published: April 2019

The purpose of this study is to ascertain the effect of weight setting of objectives on displacement and implementation difficulty in slot allocation model. Therefore, a linear integer programming model including three kinds of evaluation objectives with different weights is designed to compare and analyze displacement and implementation difficulty. Test results show that the difficulty of implementation can be significantly reduced to a certain extent by weight setting with a little increase of displacement under the condition of specific capacity setting. In addition, whether the movements are listed in order of descending priority or not has a great impact on displacement and implementation difficulty in the model. Capacity is surely a key factor affecting displacement and implementation difficulties. This study contributes to proposing an index of implementation difficulty for comparing and selecting suitable weights of evaluation objectives which can help decision makers to upgrade slot allocation policies.
Confronting Urban Planning Challenges in Chipata District, Zambia: Notes from the Field
Authors: Tuason Mata Camille
Published: April 2019

Since the public inauguration of the URP (Urban and Regional Planning) Bill in 2009, which is now law (The Urban and Regional Planning Act No. 3 of 2015), urban planning in Zambia has undergone changes. In partnership with the Volunteer Service Overseas (VSO) Federation, the Zambian parliament put into effect pilot urban planning assistance programs to assist districts around the country, including Chipata District in 2011, transition to a more decentralized, integrated and locally-defined approach to urban planning. However, the presence of discrimination, corruption, and negative attitudes towards urban planning engagement, social maladies prominently displayed in Zambian society, pose challenges to implementing the ideal goals of the 2009 URP Bill. The extreme, widespread poverty in Zambia merely exacerbates the propensity towards corrupt and discriminatory behavior, and influences poor attitudes toward urban planning engagement. This paper describes the projects undertaken by the VSO volunteer from the USA between 2011 and 2012 in the light of the specific urban problems facing Chipata District, and discusses the ways the social maladies play out in Zambian society to pose challenges to implementing the recommended changes to the planning system scribed in the 2009 URP Bill.
Supply Chain Systems Architecture and Engineering Design: Green-Field Supply Chain Integration
Authors: Radanliev Petar
Published: April 2019

This paper developed a new theory for supply chain architecture, and engineering design that enables integration of the business and supply chain strategies. The architecture starts with individual supply chain participants and derives insights into the complex and abstract concept of green-field integration design. The paper presented a conceptual system for depicting the interactions between business and supply chain strategy engineering. The system examines the decisions made when engineering the business strategy, with regards to the supply chain design. The system derived with a new understanding of how strategies are integrated, and what are the implications for engineering successful strategies. The study revealed that supply chain design is not considered in great detail before architecting the business strategies. Thus, companies consequentially experience supply chain problems that are likely to be detrimental to the growth potentials. The paper also derived with the findings that proactive and pre-emptive involvement of supply chain participants in the strategy engineering process, would lead to a more robust strategic design.
Place of Birth Inequalities in Dental Care Use Before and After the Economic Crisis in Spain
Authors: Rodriguez-Alvarez Elena , Lanborena Nerea , Borrell Luisa N.
Published: April 2019

This study evaluates inequalities in the use of dental services according to place of birth before and after the economic crisis in Spain. A cross-sectional study was performed in the population aged 18 to 65 years in Spain. We used data from three Spanish National Health Surveys for years 2006 (before the crisis), 2014 and 2017 (after the crisis). Log-binomial regression was used to quantify the association between region of origin and use of dental care services before and after controlling for the selected covariates. In 2006, we found a greater probability of not using dental care services in immigrants from Asia (PR:1.36, 95% CI:1.10–1.67) and Africa (PR:1.16; 95% CI:1.05–1.28) compared to the natives. For 2014, the probability of not using dental care services was greater for all immigrants compared to the natives, with the greatest odds for those from Africa (PR:1.71; 95% CI:1.46–2.01) and Asia (PR:1.3; 95% CI:1.23–1. 47). The associations for 2017 were weaker in magnitude than the ones observed for 2014, although stronger than for 2006. This study suggests that the economic recovery did not have the same impact for natives and immigrants regardless of regions of origin, given the observed inequalities in use of dental services.
A novel nitric oxide-donor-ferulic acid hybrid inhibits proliferation and metastasis of human lung cancer A549 cells via regulation of multiple signaling pathways
Authors: Yue Shi-Jun , Zhang Peng-Xuan , Zhu Yue , Li Nian-Guang , Chen Yan-Yan , Li Jia-Jia , Zhang Sai , Jin Ru-Yi , Yan Hao , Shi Xu-Qin , Tang Yu-Ping , Duan Jin-Ao
Published: April 2019

Lung cancer is one of the most common malignancies as well as an increasing cause of cancer-related deaths. Nitric oxide (NO)-donor-ferulic acid (FA) hybrids, in our previous study, were designed and synthesized, which exhibited positive anti-cancer activities, especially one compound labelled as FXS-3. In this study, an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were performed and revealed the inhibitory effect of FXS-3 on the proliferation and metastasis of human lung cancer A549 cells. The further flow cytometry assay showed that FXS-3 induced apoptosis of A549 cells by inducing cell cycle arrest at the G0/G1 phase. The trans-well migration and Matrigel invasion assays revealed that FXS-3 inhibited the migration and invasion of A549 cells. By the western blotting analysis, FXS-3 increased the expression of B-cell lymphoma-2 (Bcl-2) associated X protein (Bax)/Bcl-2 ratio, inhibited matrix metalloproteinase (MMP)-2 and MMP-9, and suppressed the mitogen-activated protein kinase (MAPK), AKT/mechanistic target of rapamycin (mTOR), as well as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathways. The subsequent A549 xenograft-bearing mouse model and tail vein injection of A549 cells induced pulmonary tumor metastasis model showed that FXS-3 significantly restrained the tumor growth and metastasis. In conclusion, FXS-3 might inhibit proliferation and metastasis of human lung cancer A549 cells by inhibiting MAPK, AKT/mTOR and MEK/ERK signaling pathways, which provides important scientific basis for the development of anti-cancer drugs about NO-donor-FA hybrids.
Quantum Entropic Gravity with Quantum Field Theory and General Relativity : A First Approach with Bijective Physics
Authors: Baudrimont Roman
Published: April 2019

The purpose of this paper is to find a quantum formulation of entropic gravity, incorporating the bijective theory. In a first part, we will describe the basis of the bijective theory. In a second part, we will incorporate the stress energy quantum tensor defined in the linear approximation of the Einstein’s equation in its quantum version to entropy. In the third part, we will integrate the bijective theory with the newly created relativistic quantum entropy. This will lead us four part where we will formalize quantum entropic gravity.
Optimasi Kapasitas Baterai Dinamis Asam Timbal (Redox Flow Battery)
Authors: Khairati Nur , Ghufron Muhammad , Pranata Kurriawan Budi
Published: April 2019

Baterai dinamis atau yang dikenal dengan Redox Flow Battery (RFB) merupakan jenis baterai sekunder yang banyak dikembangkan karena kemampuannya untuk menyimpan energi dalam jumlah besar. Pada penelitian ini, dikembangkan baterai dinamis berbasis asam timbal dimana timbal (Pb) dan timbal dioksida (PbO2) digunakan sebagai elektroda baterai dengan luas permukaan pelat (13,5 x 7,5) cm2. Baterai dinamis asam timbal diuji sehingga diketahui pengaruh perbedaan konsentrasi H2SO4 terhadap karakteristik baterai. Variasi konsentrasi H2SO4 yang digunakan adalah 20% dan 30%. Pengujian siklus pengisian-pengosongan dilakukan dengan alat BMS (Battery Management System) yaitu Turnigy Accucell-6 sebanyak 3 siklus dengan arus pembebanan 1 A. Berdasarkan hasil penelitian, kapasitas baterai dinamis asam timbal meningkat dengan meningkatnya konsentrasi H2SO4. Baterai dinamis asam timbal 30% menghasilkan kapasitas rata-rata tertinggi yaitu 4.657 mAh dengan efisiensi rata-rata 82,90%. Baterai dinamis 30% diuji masing-masing 1 siklus dengan variasi waktu pengisian untuk mengetahui waktu pengisian optimal baterai. Variasi waktu pengisian yang digunakan adalah 0,5; 1; 1,5; 2; 2,5 jam serta pengisian hingga titik cut-off . Hasil penelitian menunjukkan bahwa kapasitas baterai meningkat dengan meningkatnya waktu pengisian baterai, dengan efisiensi tertinggi baterai dinamis 30% adalah pada pengisian 2 jam.
Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression
Authors: Long Pan , Yan Weiming , He Mengshan , Zhang Qianli , Wang Zhe , Li Manhong , Xue Junhui , Chen Tao , An Jing , Zhang Zuoming
Published: April 2019

Background: Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to evaluate the effecacy of hydrogen gas on the BRVO rat model.
Methods: Twenty-four BRVO rats were randomly divided into two groups: the hydrogen gas (H) group (42% H2, 21% O2, 37% N2) and the model (M) group (21% O2, 79% N2). Rats in the H group inhaled hydrogen gas for 8 h every day up to 30 d post-occlusion. Twelve age-matched healthy rats served as the control (C) group. Retinal function and morphology were detected at 1, 7, 14 and 30 d post-occlusion. Furthermore, the expression of vascular endothelial growth factor (VEGF-α) was detected by immunofluorescent staining.
Results: Full-field electroretinography (ffERG) revealed that the amplitude of the b-wave (dark-adaptation 3.0 response), the amplitude of the OPs2 wave and the light-adapted flicker response in the H group were all higher than those in the M group at 7 d post-occlusion (all p<0.05). The reopen time of occlusive retinal vessels in the H group was 2.235 ± 1.128 d, which was shorter than that in the M group (4.234±2.236 d, p<0.05). The rats in the H group had a thinner IPL+GCL+NFL and an increased total retina compared with those in the M group at 3 d post-occlusion (p<0.05), while the rats in the H group had a thicker INL, IPL+GCL+NFL and total retina compared with those at 7, 14 and 30 d post-occlusion (p<0.05). Moreover, the flow velocity of ear vein blood was increased in the H group compared with that in the M group (p<0.05). The expression of VEGF-α in the H group was dramatically decreased compared with that in the M group at 1, 7 and 14 d post-occlusion (p<0.05), while the expression kept in similar level at 30 d post-occlusion (p>0.05).
Conclusions: Our findings demonstrate that inhalation of hydrogen gas could alleviate retinal oedema, shorten reopen time and improve retinal function, and the potential mechanism might be related to a decrease in VEGF-α expression.
Protocol for aquaphotomics monitoring of water molecular structure in leaves of resurrection plants during desiccation and recovery
Authors: Muncan Jelena , Kuroki Shinichiro , Moyankova Daniela , Morita Hiroyuki , Atanassova Stefka , Djilianov Dimitar , Tsenkova Roumiana
Published: April 2019

Plant stress responses are complex phenomena encompassing an array of changes at molecular and cellular level. They leave imprint on the molecular structure of water in the plant tissues which can be measured in vivo, in a completely non-destructive and reagent-free way, using aquaphotomics near infrared spectroscopy. Analysis of the near infrared spectrum regions, where water absorbs, provides indirect insight into the dynamics and functionality of the whole biological system.In our efforts to perform Responsible Research and Innovations (RRI) practices, we display openly the details of our approach showing the advantages and the eventual difficulties. The protocol described here is developed for non-destructive monitoring of plant response to desiccation stress, particularly focused on the extreme desiccation tolerance of resurrection plants. With alterations in plant material and experimental conditions, the methods described allow detection, monitoring and analysis of plant response to stress in general - abiotic and biotic.
Exploration of candidate serum biomarkers potentially related to the chronic pain condition in Medication Overuse Headache (MOH)
Authors: Pellesi Lanfranco , Bellei Elisa , Guerzoni Simona , Cainazzo Maria Michela , Baraldi Carlo , Monari Emanuela , Pini Luigi Alberto
Published: April 2019

Background

Medication Overuse Headache (MOH) is a prevalent and disabling disorder resulting from the overuse of analgesic drugs, triptans or other acute headache medications. In previous proteomic studies, several proteins have been found at high concentrations in the urine of MOH patients and in the serum of rats with neuropathic pain. The aim of this study was to compare the serum levels of lipocalin-type Prostaglandin D2 synthase (L-PGDS), Vitamin D-binding protein (VDBP), apolipoprotein E (APOE) and apolipoprotein A1 (APOA1) in MOH patients and healthy individuals, further exploring their relationship with cutaneous pain thresholds (CPTs) in the territories innervated by the trigeminal nerve.

Methods

69 MOH patients and 42 age- and sex-matched healthy volunteers were enrolled in the study. Von Frey-like filaments were applied to the skin territories innervated by the trigeminal nerve, to determine the CPTs. L-PGDS, VDBP, APOE and APOA1 were quantified in the serum by Enzyme-linked Immunosorbent Assay (ELISA). Clinical and laboratory data were collected. Comparisons between MOH patients and healthy individuals were performed using independent t test or χ2 test. To correlate serum proteins with CPTs, Pearson correlation coefficient or Spearman's rank correlation coefficient were used.

Results

CPTs were lower among MOH patients. L-PGDS, VDBP and APOE had significantly different serum concentrations between groups (p < 0.01), but no correlation was found with CPTs. APOA1 serum concentrations did not differ between patients and healthy individuals.

Conclusions

L-PGDS, VDBP and APOE had abnormal serum levels in MOH patients, confirming their alteration in some conditions of chronic headache and neuropathic pain. The in-depth study of target proteins represents a promising approach for a better understanding of MOH, as well as the detection of candidate biomarkers for chronic headache or the risks associated with overuse medications.
On Rare Variants in Principal Component Analysis of Population Stratification
Authors: Ma Shengqing , Shi Gang
Published: April 2019

Background

Population stratification is a known confounder of genome-wide association studies, as it can lead to false positive or false negative results. Principal component analysis (PCA) method is widely applied in the analysis of population structure with common variants. It is still controversial whether this method is effective when using rare variants to distinguish population stratification.

Results

In this work, we derive a mathematical expectation of the genetic relationship matrix. Variance and covariance elements of the expected matrix depend explicitly on allele frequencies of the genetic markers used in the PCA analysis. We show analytically that inter-population variance is contained in K principal components (PCs) and mostly in the largest K-1 PCs, where K is the number of populations in the samples. When allele frequencies become small, the ratio of the inter-population variance in the K PCs to the intra-population variance abates, the portion of variance explained by the K PCs decreases, and the distance among populations diminishes. As a result, the PCA of population stratification performs worse with rare variants than with common ones. The results are validated in the analysis of the 1000 Genomes Project data. The ratio of the two variance components is 93.85, variance explained by the largest five PCs is 17.09%, and population distance is 444.38 when using with common variants with allele frequencies between 0.4 and 0.5. However, the ratio, percentage and distance decrease to 1.83, 0.74% and 17.83, respectively, with rare variants of frequencies between 0.0001 and 0.01.

Conclusions

Although the vast majority of rare variants are population-specific and may have richer ancestry information than common ones, new methods must be developed to exploit the information effectively.
Phospholipid Fatty Acid Profiles of Soils under Variable Handling and Storage Conditions
Authors: Veum Kristen S. , Lorenz Todd , Kremer Robert J.
Published: April 2019

Core Ideas

Sample handling had profound and disproportionate effects on PLFA biomarkers.

Gram positive and actinobacteria were not significantly affected by storage.

Gram negative and fungal biomarkers were dramatically affected by storage.

PLFA ratios significantly changed as a result of sample handling and storage.

Interpretation of PLFA profiles is highly sensitive to sample handling.

Phospholipid fatty acid (PLFA) analysis is an increasingly popular method for estimating microbial biomass and assessing microbial community structure in soils. In particular, there is a strong interest in the use of PLFA microbial group ratios as benchmarks for soil health assessment and interpretation. Due to the sensitivity of PLFA biomarkers, the recommended procedure for sample handling involves immediate analysis of fresh, field‐moist soil, immediate lyophilization with freezer storage, or storage at –80°C. This protocol may not be practical under all circumstances, yet the effects of handling and storage conditions, and the implications for interpretation of PLFA biomarkers, are not fully understood. The primary objective of this study was to evaluate the effects of multiple sample handling and storage conditions on quantification and interpretation of PLFA biomarkers. A suite of soil properties were measured on 17 prairie soil samples, including PLFA analysis. Multiple processing and handling procedures were evaluated by splitting the soil samples and comparing PLFA profiles from (i) fresh soil, (ii) soil stored air‐dry for 7 and 14 d, (iii) soil stored field‐moist at room temperature for 7 and 14 d, and (iv) soil oven‐dried for 24 h at 105°C. All handling and storage procedures resulted in significant losses of PLFA biomarkers relative to fresh, lyophilized samples and microbial groups were disproportionately affected, leading to significant shifts in biomarker ratios. Overall, this study highlights the sensitivity of PLFA biomarkers, the importance of proper sample handling for PLFA analysis, and the potential for error and misinterpretation of PLFA data.
Statistical Analysis of Non‐Replicated Experiments in Farmers’ Fields. A Case of Balanced Fertilization Trials for Bean in Burundi
Authors: Sanabria Joaquin , Wendt John
Published: April 2019

Core Ideas

Often agronomic experiments in farmers’ fields do not allow replications.

Between‐fields spatial variability can be used to model the error variance.

The modeled error variance in a GLMM is used to test treatment‐related hypotheses.

Using fields as replications can end in biased results due to fields’ autocorrelation.

Very often agricultural experiments in smallholder farms are conducted without actual replications due to land restrictions. Using fields as replications and performing the ANOVA with a randomized complete block design (RCBD) model can result in misleading conclusions about treatment’s performance due to a biased error variance matrix estimated under the wrong assumption of independence between fields. A better alternative is using the spatial variability modeling features of the GLMM to generate an error term to perform unbiased hypothesis tests. Non‐replicated trials to estimate bean response to three fertilization treatments were conducted across 175 farmers’ fields in Burundi. Yields were used to compare the performance of an ANOVA using a GLMM where the exponential autocorrelation pattern of the residuals was used to model the error variance‐covariance matrix against an ANOVA following a RCBD model where the fields are handled as blocks. The fields were grouped in three clusters prior to the ANOVA. AIC and the Generalized Chi‐Sq./DF ratio values for the model involving spatial modeling were 165.3 and 1, respectively. The same fit statistic values from the RCBD model were 330.1 and 0.1, respectively. The near‐half magnitude of AIC in the spatial model relative to the RCBD model indicates higher model goodness of fit for the spatial model. The 0.1 value for the Generalized Chi‐Sq./DF ratio in the RCBD model suggests underdispersion and violation of the independence‐between‐fields assumption. Detection of a significant CLUSTER*TREATMENT by the spatial model corroborates the superiority of the ANOVA model involving spatial variability.
Spatial and Temporal Variation in Soil Nitrous Oxide Emissions from a Rehabilitated and Undisturbed Riparian Forest
Authors: De Carlo N. D. , Oelbermann M. , Gordon A. M.
Published: April 2019

Riparian zones enhance water quality and provide wildlife habitat, but high nutrient input in agricultural landscapes causes nitrous oxide (N2O) emissions, potentially negating their benefits of C sequestration. The objectives of this study were to quantify spatiotemporal N2O emissions in a rehabilitated and undisturbed natural riparian forest. We also determined soil and vegetation characteristics, and their role in driving spatiotemporal N2O emissions. Mean N2O‐N emissions were not significantly (p < 0.05) different between rehabilitated (7.62 μg m−2 h−1) and undisturbed (5.93 μg m−2 h−1) riparian forests. The greatest (p < 0.05) N2O‐N emissions in both riparian forests were observed during the summer. Soil moisture, temperature, and N were significantly correlated to N2O‐N emissions. Our results show that soil and vegetation characteristics varied between the two riparian forests, but differences in N2O‐N emissions were negligible. We also found that N2O emissions were influenced by soil characteristics and seasonality, rather than vegetation characteristics or spatial position.

Core Ideas

N2O emissions are influenced temporally rather than spatially in riparian zones.

Rehabilitated and undisturbed riparian forests have similar N2O emissions.

Seasonality and soil characteristics had a greater influence on N2O emissions than vegetation.

Riparian systems generated hot moments rather than hot spots of N2O emissions.
Evaluation of Arsenic Leaching Potential in Gold Mine Tailings Amended with Peat and Mine Drainage Treatment Sludge
Authors: Rakotonimaro T. V. , Guittonny M. , Neculita C. M. , Trépanier F. , Pépin G.
Published: April 2019

Peat and mine drainage treatment sludge can be valorized as amendments on mine sites to stabilize gold mine tailings and reduce the potential leaching of contaminants in pore water. However, the influence of organic amendments on the mobility of metalloids and/or metals in the tailings must be validated, as the leached contaminants may vary according to their type, nature, and origin. The objective of the present study was to evaluate over time the effect of peat‐ and/or Fe‐rich sludge amendments on the mobility of As and metallic cations in the drainage water of tailings potentially producing contaminated neutral drainage. Ten duplicated weathering cell experiments containing tailings alone or amended with peat and/or Fe‐rich sludge (5–10% dry weight) were performed and monitored for 112 d. The results showed that as low as 5% peat amendment would promote As mobility in tailings’ pore water, with As concentrations exceeding Quebec discharge criteria (>0.2 mg L−1). In addition, As(III), the most mobile and toxic form, was predominant with 10% peat, whereas organic species were negligible in all cells. The use of peat alone as organic amendment for the stabilization of tailing contaminants could increase the risk of generating As‐rich contaminated neutral drainage. Conversely, the mix of only 5% Fe‐rich sludge with or without peat decreased As concentrations in leachates by 65 to 80%. Further studies on the use of “peat” or “peat + Fe‐rich sludge” as cover or amendment should be conducted with a focus on Fe/As and Ca/As ratios.

Core Ideas

Peat amendments enhanced the leaching of As from gold mine tailings.

Amendments of 5% peat promoted As(V) leaching, whereas 10% peat increased As(III) leaching.

As(III) was predominant at ≥20 mg L−1 dissolved organic C from peat.

Mine drainage treatment sludge could decrease As concentrations by 65 to 80% in tailings’ pore water.
Compressibility of synthetic Mg-Al tourmalines to 60 GPa
Authors: Berryman Eleanor J. , Zhang Dongzhou , Wunder Bernd , Duffy Thomas S.
Published: April 2019

High-pressure single-crystal X-ray diffraction patterns on five synthetic Mg-Al tourmalines with near end-member compositions [dravite NaMg3Al6Si6O18(BO3)3(OH)3OH, K-dravite KMg3Al6Si6O18(BO3)3(OH)3OH, magnesio-foitite □(Mg2Al)Al6Si6O18(BO3)3(OH)3OH, oxy-uvite CaMg3Al6Si6O18(BO3)3(OH)3O, and olenite NaAl3Al6Si6O18(BO3)3O3OH, where □ represents an X-site vacancy] were collected to 60 GPa at 300 K using a diamond-anvil cell and synchrotron radiation. No phase transitions were observed for any of the investigated compositions. The refined unit-cell parameters were used to constrain third-order Birch-Murnaghan pressure-volume equation of states with the following isothermal bulk moduli (K0 in GPa) and corresponding pressure derivatives (K0′ = ∂K0/∂P)T: dravite K0 = 97(6), K0′ = 5.0(5); K-dravite K0 = 109(4), K0′ = 4.3(2); oxy-uvite K0 = 110(2), K0′ = 4.1(1); magnesio-foitite K0 = 116(2), K0′ = 3.5(1); olenite K0 = 116(6), K0′ = 4.7(4). Each tour-maline exhibits highly anisotropic behavior under compression, with the c axis 2.8–3.6 times more compressible than the a axis at ambient conditions. This anisotropy decreases strongly with increasing pressure and the c axis is onlŷ14% more compressible than the a axis near 60 GPa. The octahedral Y- and Z-sites' composition exerts a primary control on tourmaline's compressibility, whereby Al content is correlated with a decrease in the c-axis compressibility and a corresponding increase in K0 and K0′. Contrary to expectations, the identity of the X-site-occupying ion (Na, K, or Ca) does not have a demonstrable effect on tourmaline's compression curve. The presence of a fully vacant X site in magnesio-foitite results in a decrease of K0′ relative to the alkali and Ca tourmalines. The decrease in K0′ for magnesio-foitite is accounted for by an increase in compressibility along the a axis at high pressure, reflecting increased compression of tourmaline's ring structure in the presence of a vacant X site. This study highlights the utility of synthetic crystals in untangling the effect of composition on tourmaline's compression behavior.
The single-crystal elastic properties of the jadeite-diopside solid solution and their implications for the composition-dependent seismic properties of eclogite
Authors: Hao Ming , Pierotti Caroline E. , Tkachev Sergey , Prakapenka Vitali , Zhang Jin S.
Published: April 2019

The 13 single-crystal adiabatic elastic moduli (Cij) of a C2/c jadeite sample close to the ideal composition (NaAlSi2O6) and a natural P2/n diopside-rich omphacite sample have been measured at ambient condition by Brillouin spectroscopy. The obtained Cij values for the jadeite sample are: C11 = 265.4(9) GPa, C22 = 247(1) GPa, C33 = 274(1) GPa, C44 = 85.8(7) GPa, C55 = 69.3(5) GPa, C66 = 93.0(7) GPa, C12 = 84(1) GPa, C13 = 66(1) GPa, C23 = 87(2) GPa, C15 = 5.4(7) GPa, C25 = 17(1) GPa, C35 = 28.7(6) GPa, C46 = 14.6(6) GPa. Voigt-Reuss-Hill averaging of the Cij values yields aggregate bulk modulus KS = 138(3) GPa and shear modulus G = 84(2) GPa for jadeite. Systematic analysis combing previous single-crystal elasticity measurements within the diopside-jadeite solid solution indicates that the linear trends are valid for most Cij values. The νp and νs of omphacite decrease with diopside content, though the velocity changes are small as diopside component exceeds 70%. We also found that both the isotropic νp and νs, as well as the seismic anisotropy of eclogite, changed strongly with the bulk-chemical composition. The relationship between the anisotropic velocities of eclogite and the chemical composition can be a useful tool to trace the origin of the eclogitic materials in the Earth's mantle.
The effect of sustainability accounting disclosures on financial performance: an empirical study on the Jordanian banking sector
Authors: Hel Al-Dhaimesh Othman , Kamel Al Zobi Mo’taz
Published: April 2019

This study aims to examine the effect of sustainability accounting disclosure on the financial performance of banks operating in Jordan during the period of 2013–2017. The study focused on the effect of economic, environmental and social disclosures on financial performance. To achieve the study objective, the content analysis method was used. The dimensions of sustainability accounting disclosure were measured through indicators that have been developed for this purpose, which are in accordance with Global Reporting Initiative (GRI) (G4-2013). The study results revealed that there is a statistically significant effect of sustainability accounting disclosure on the financial performance. In addition, the study results revealed that the disclosure of the economic and social dimensions had a positive effect on return on equity (ROE). While the environmental dimension did not affect the return on equity (ROE). In addition, the results of the study revealed that the disclosure of sustainability dimensions (economic, social and environment) had a combined effect on the return on assets (ROA). This means that the banks operating in Jordan give more priority to the economic dimension disclosure, than to the social and environmental dimensions.In reviewing previous studies in the accounting literature, it has been found that there is a paucity of studies that examine the concept of sustainability accounting, especially in the Jordanian banking sector. Therefore, this study constitutes value to this field.
Excitation mechanism of hydroelastic oscillations in a pipeline
Authors: Ilgamov M.A. , Lukmanov R.L. , Zaripov D.M.
Published: April 2019

The article considers bending oscillations generated in the vertical plane of a horizontal liquid-filled pipe under the impact of a harmonic pressure wave in the liquid in the cases that the ends of the pipe are fixed in two different ways. The investigation is focused on the impact of the initially curved position of the pipe and the excitation frequency on the behaviour of forced and parametric oscillations. The conditions are reveled for the occurrence of nonlinear resonance and also the excitation of upper harmonics/ The oscillations of the system vary from periodic to chaotic depending on the parameters of the problem.
Nonlinear analog of the Plesset equation for nonspherical motion of a gas bubble
Authors: Ilgamov M.A. , Nasibullaeva E.Sh.
Published: April 2019

An equation analogous to Plesset's equation that describes the non-spherical motion of a gas bubble in an ideal incompressible fluid is derived. The terms containing the squares of the amplitude of the non-free perturbation were taken into account, whereas in the derivation of the Plesset equation only the linear terms are taken into account. On the basis of the obtained equations numerical calculations of the nonspherical oscillations of the bubble were carried out. A comparison of the obtained results and the Plesset equation showed that with a sufficient increase in the perturbation amplitude, the nonlinear terms begin to affect that is lead to solution limitation.
Modeling of pressure losses on friction in three-layer laminar flows
Authors: Ilyasov A.M.
Published: April 2019

In this paper we propose a model for determining the pressure loss due to friction in each phase in a three-layer laminar steady flow of immiscible liquid and gas flow in a flat channel.

This model generalizes an analogous problem for a two-layer laminar flow, proposed earlier. The relations obtained in the final form for the pressure loss due to friction in liquids can be used as closing relations for the three-fluid model.

These equations take into account the influence of interphase boundaries and are an alternative to the approach used in foreign literature. In this approach, the wall and interphase voltages are approximated by the formulas for a single-phase flow and do not take into account the mutual influence of liquids on the loss of pressure on friction in phases. The distribution of flow parameters in these two models is compared.
On the duality of the solution of the problem of finding the relative rigidity of the elastic edge edges of a cylindrical shell with respect to two eigenfrequencies of its axisymmetric oscillations
Authors: Akhtyamov A.M. , Safina G.F.
Published: April 2019

We consider the inverse problem of finding the relative rigidity of elastic edge edges of a cylindrical shell that is inaccessible to visual inspection, by two natural frequencies of its axisymmetric vibrations. A theorem on the duality of the solution of this inverse problem is proved. The corresponding counterexamples are given.
The effect of a pressure wave on a rigid wall covered with a porous layer
Authors: Lukin S.V.
Published: April 2019

The influence of the non-stationary Basset-Boussinesq forces on the reflection of a step-type pressure wave from a solid surface coated with a porous layer, a saturated liquid or a gas is investigated. The study of wave processes is carried out within the framework of the multi-velocity continuum model. A comparative analysis of the properties of porous screens saturated with a liquid or gas is carried out. The degree of influence of the non-stationary Basset-Boussinesq force on reflection of a wave from a solid wall covered with a porous substance is established.
Página Legal del No. 18 de la Revista de El Colegio de San Luis, Nueva Época
Authors: El Colegio de San Luis Revista de
Published: April 2019

Se presentan en este documento los datos y nombres de las autoridades de El Colegio, así como el número y fecha de publicación de este ejemplar. Se incluye también información de los integrantes del Consejo Editorial.Se incluye además información del Director de la Revista y nombres de contacto de algunos de los colaboradores de la misma, algunos datos de impresión y el tiraje de los ejemplares impresos.