bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation of Circulating Plasma Cells in Multiple Myeloma on a Novel Automated System
Authors: Sa Silin , Hsu Faye , Oaks Jean , Spiteri Liz , Williams Jesse , Yu Liping
Published: February 2023

Multiple myeloma is a cancer of disordered plasma cells. The disease poses significant challenges for clinical management where cytogenetic analysis, such as FISH (fluorescent in situ hybridization), was commonly used for diagnosis and prognosis. Beads based enrichment of plasma cells are widely used to enhance FISH sensitivity and specificity. However conventional beads-based methods often require time-consuming sample preparation and results in low cell recovery.

Here we present an easy and automated method to positively isolated CD138+ plasma cells from bone marrow samples. The method is developed on a novel designed magnetic separation system, MARS®. MARS® is matrix-free magnetic separation platform providing high purity, high recovery, and high capacity for cell isolation. Magnetic bead labeled CD138+ cells are isolated directly from bone marrow and peripheral blood without centrifugation. In the pilot study, U266 cells were spiked into peripheral blood from 0.5% to 2.0% of white blood cells frequency range. In addition, healthy donor bone marrow cell sample with 0.04% plasma cells were processed on MARS®. Plasma cells were isolated at 1mL/min flow rate followed by automated rinsing and releasing on MARS®. 48% to 80% recovery of the plasma cells were obtained. Results show our method has advantage in fast (<30 minutes), easy process with high recovery. Our next objective will be to validate the method on Multiple Myeloma patient specimens and compared to conventional beads-based enrichment methods. Enriched plasma cells will be analyzed by FISH to prove the enhanced sensitivity with better enrichment method.
Frozen CyTOF panel enables robust and consistent longitudinal assessment of the SARS-CoV-2 immune landscape
Authors: Acosta-Vega Carolina , Skibinski David , Kus Anna , Speak Cate , Long Alice , Malhotra Uma , Buckner Jane H , Wiedeman Alice
Published: February 2023

During the Coronavirus Disease 2019 (COVID-19) outbreak, a robust and consistent strategy was required for assessing the immune landscape. Our rapid research response to COVID-19 was enabled by use of standardized assays. The assays included a 33-marker mass cytometry (CyTOF) panel that characterized major immune cells subsets in fresh whole blood including both innate and adaptive cells. Intraassay variation, determined by staining of the same fresh whole blood sample independently by two technicians on the same day, was CV<20% for populations with a frequency >5%. However, technical consistency was crucial to accurately capture and compare immune changes. Thus, we tested the stability of an antibody cocktail stored at −80C to limit inherent variability in daily panel preparation. Using lyophilized whole blood and cryopreserved R848-stimulated PBMC as controls encompassing the breadth of cell subsets and markers, we assessed the panel performance 7 times (at days 0, 16, 33, 42, 56, 72 and 96 after freezing). We found stability of staining over time: variability of the frozen cocktail was comparable to repeated cocktail preparations as seen in rare plasmablasts (CV<25% frozen vs 13.1% repeat fresh), but also CD4 T cells (CV<13% vs 10.6%), and neutrophils (CV<4% vs 9.8%). Applying the highly-consistent frozen cocktail to study of 59 COVID-19 subjects revealed changes in common subsets (CD4 central memory T cells increased >30% with severe disease), but also in rare plasmablasts (increased 6% of CD19), and more subtle neutrophil changes (increased 15% of CD45). Thus, freezing a high-content CyTOF panel cocktail provides a reliable method to control variability of staining in assays where sample collection is variable.
B-cell lymphoma 6 protein modulates function of human tonsillar innate lymphoid cells
Authors: Ohayon David E , Clay Gwendolyn M. , Forney Carmy , Seelamneni Harsha , Sestito Alexandra , Duggins Angela , Fitzpatrick Sarah , Guilliams Harmon , Kottyan Leah C. , Smith David F. , Miraldi Emily R. , Waggoner Stephen N
Published: February 2023

Innate lymphoid cells (ILC) play a fundamental role in mucosal homeostasis and immunity via expression of cytokines such as IL-22, IL-17A and IFN-γ. However, the transcriptional network that controls ILC functional identity is incompletely defined. Previously, we demonstrated that BCL6 plays a key role in transcriptional regulation in mouse intestinal ILC1 and ILC3. Here, we performed in vitro cultures of ILCs isolated from human tonsil in the presence of cytokines that promote ILC1 or ILC3 in order to assess the role of BCL6 in functional plasticity of ILCs. ILCs were treated with IL-2 and IL-12/IL-1β or IL-23/IL-1β in the presence or absence of the BCL6 inhibitor FX-1. In the context of IL-12/IL-1β ILC1-promoting culture, FX-1 inhibition of BCL6 reduced expression of Tbet and IFN-γ. In contrast, BCL6 inhibition in the context of IL-23/IL-1β ILC3-inducing conditions had no effect on Tbet, IFN-γ, or RORγt. In either context, FX-1 resulted in reduced IL-22 but increased IL-17A expression in comparison to vehicle treated cultures. Thus, our data emphasizes the role of BCL6 as a regulator of human tonsil ILC functional identity.
Epidemiology and psychosocial assessment of COVID-19 among workersof the Nigeria Centre for Disease Control infected with COVID-19
Authors: Saleh Fatima , Olatunji David Idowu , Ofeimun Ehichioya , Okpokoro Evaezi , Crawford Emily , Dalhat Mahmood , Igumbor Ehimario , Eziechina Sunday , Inweregbu Stella , Ochu Chinwe Lucia , Chikwe Ihekweazu
Published: February 2023

Background. COVID-19 is a global health crisis. By 2021, Nigeria had 230,000 cases. As the national public health institute, NCDC leads the COVID-19 response. Due to constant contact with infected patients, agency employees are at high-risk. Here, we describe the transmission and psychosocial effects of COVID-19 among infected NCDC workers as a learning curve for minimizing occupational transmission among frontline public health workers in future outbreaks.Methods. We approved and enrolled all NCDC COVID-19-infected personnel from November to December 2020. We collected data using SurveyMonkey. STATA 14 analyzed the data.Results. 172 of 300 afflicted NCDC staff participated in this study. One-third were between 30 and 39; most were male (104, 60.5%). Most participants worked in the lab (30%) or surveillance (24%). Only 19% (33/172) of participants confirmed pandemic deployment. Most reported interaction with a confirmed case (112/65.1%). Most people (78, 45.3%) felt unhappy when diagnosed. Anger, worry, and low motivation also ranked high (19). The majority reported adequate financial, moral, or psychosocial assistance (26, 70.6%).Conclusions. NCDC staff had a high SARS-CoV-2 infection rate and emotional damage. We urge stricter infection control methods when sending staff for outbreaks response to prevent additional transmission, as well as ongoing psychosocial and economic assistance for afflicted workers.
Study of coronavirus disease 2019 cases at the isolation department of el-dakhla general hospital
Authors: Tageldein Mohamed A. , Mohamed Mahmoud M. , Ibrahim Mai M.
Published: February 2023

Background

Coronavirus disease 2019 (COVID-19) infection is currently the greatest atypical pneumonia outbreak, causing widespread anxiety and fear.

Objectives

To study cases with clinical manifestations that have been identified as COVID-19 according to the Egyptian Ministry of Health’s criteria, their management protocol, and outcome data at the isolation department of El-Dakhla General Hospital.

Patients and methods

This work was performed upon 106 patients with clinical symptoms of COVID-19 at the isolation department of El-Dakhla General Hospital.

Results

Mortality was associated with older age. No patients within the died group had been vaccinated. Vaccination was significantly associated with decreased severity of chest affection, admission to the ICU, and duration of admission. Mortality was associated with severity of chest affection. All died patients were admitted to the ICU. This study also revealed that abnormal vital and laboratory data were significantly associated with mortality. On using binary regression analysis of factors to be significantly associated with mortality, lower duration of admission and not being admitted to ICU decreased the risk of mortality among the studied patients, yet was statistically nonsignificant (P>0.05), whereas higher C-reactive protein on admission increased the risk by 1.186 folds.

Conclusion

Age, vaccination state, severity of chest affection, ICU admission and duration, use of some medications, vital data, and laboratory data are important factors to assess the prognosis and severity of COVID infection.
Endobronchial inflammatory polyps
Authors: Joshi Sharad , Tayal Nitesh , Gupta Rajesh , Bhatia Ankit
Published: February 2023

Endobronchial inflammatory polyps are one of the rarest benign bronchial tumors. Tumors of benign etiology are even rare. Inflammatory bronchial polyps are frequently solitary although rarely can be multifocal. We are presenting a rare case of multiple endobronchial inflammatory polyps presenting as pneumonia.
The effect of coronavirus disease 2019 severity on male sexual functions among patients on follow-up after hospital discharge
Authors: Mousa Mohamed S. , Elshazly Mostafa , El Salam Mohamed A.A. , Ahmed Salwa H. , Tantawy Ahmed A.
Published: February 2023

Objectives

Severe acute respiratory syndrome coronavirus 2 has infected millions of people worldwide with extensive affection and damage to body systems and organs; hence, the study of post-coronavirus disease (COVID) sequences is mandatory. Till now, reports are upcoming on the considerable effects of COVID-19 on male sexual health with no final data.

Patients and methods

Our cohort study included 76 male COVID-19-infected patients, confirmed positive via nasopharyngeal PCR swab. The rationale of this study was to estimate the influence of clinical, laboratory, and radiological severity parameters of COVID-19 on male erectile dysfunction based on erectile scores and male sex hormones (follicle-stimulating hormone, luteinizing hormone, testosterone, and estradiol).

Results

Our results have demonstrated a highly statistically significant correlation between COVID-19 severity (mild, moderate, and severe cases) and both erectile scores (erection hardness score and International Index of Erectile Dysfunction-5) and testosterone hormones at first and third month after COVID (P<0.001), except for testosterone level at third month and COVID-19 severity, which showed a statistically significant difference, with P value of 0.031.

Conclusions

The current study correlated the effect of COVID-19 severity in the terms of clinical, laboratory, and radiological presentations on male sexual dysfunction (erectile scores and testosterone hormone) at first and third month after hospital discharge, with statistical significance being highly affected in severe rather than moderate and mild cases. This strengthens the obvious effect of COVID-19 infection on male sexual dysfunction.
Reactivation of retinopathy of prematurity after intravitreal bevacizumab monotherapy in aggressive posterior retinopathy of prematurity
Authors: Verma Ritesh , Rathi Manisha , Phogat Jitender , Sodhi Amita , Lochab Sakshi
Published: February 2023

Aims:

The aim of the study was to identify the risk factors and timing for the reactivation of retinopathy of prematurity (ROP) after intravitreal bevacizumab (IVB) in aggressive posterior retinopathy of prematurity (APROP).

Materials and Methods:

A retrospective study to analyze the outcome of 24 eyes of 12 infants treated with IVB monotherapy (0.625 mg) was done. Data were analyzed regarding the initial response to IVB, the incidence of ROP reactivation, timing, location, and stage of reactivation. Gestational age, postmenstrual age, and other neonatal comorbid risk factors were compared between the reactivation and those without reactivation after IVB.

Results:

The mean follow-up time was 50.2 ± 1.4 weeks after IVB. Reactivation was identified in 8 (33.3%) eyes. Reactivation in zone I was seen in only two eyes and zone II reactivation was present in six eyes. The mean postmenstrual age at the time of recurrence was 44.0 ± 1.15 weeks (range: 43–45). The mean time between initial treatment and treatment-requiring recurrence was 11.8 ± 0.9 weeks. Multiple pregnancy, low birth weight, sepsis, and necrotizing enterocolitis were significantly associated with ROP reactivation. None of our patients progressed to retinal detachment after laser treatment for reactivation.

Conclusions:

Although IVB treatment is effective in inducing the regression of APROP, the effect may be transient. The recurrence of ROP should be carefully watched in a long-term follow-up after IVB monotherapy, particularly in the first 12 weeks after IVB.
Correlation of the activities of antioxidant enzymes superoxide dismutase and glutathione reductase with micronuclei counts among areca nut chewers of Manipuri population using exfoliative cytology
Authors: Sanjeeta Ngairangbam , Banerjee Sumita , Mukherjee Saikat , Devi T. Premlata , Nandini D. B. , Aparnadevi P.
Published: February 2023

Context:

Areca nut (AN) is a potent cytotoxic and genotoxic agent. Oxidative stress-induced by chewing of AN can cause DNA damage leading to nuclear anomalies such as micronuclei (MN) and also alters antioxidant defense mechanisms, leading to genomic instabilities and the development of oral cancer.

Aims:

The aim of this study is to study the correlation between the levels of glutathione reductase (GR) and superoxide dismutase (SOD) in exfoliated buccal mucosal cells and the genotoxicity levels (MN count) in chronic AN chewers.

Materials and Methods:

The present study was conducted with the approval of the Research Ethics Board in 60 individuals; 40 cases (Group I–20 raw AN chewers, Group II–20 dried areca with tobacco chewers), and 20 controls as Group III in the age group of 18–68 years who attended the outpatient department of our college. Estimation of SOD and GR and MN assessment was done using buccal exfoliated cells.

Statistical Analysis Used:

Statistical analysis was performed using the Student's t-test and one-way ANOVA.

Results:

Antioxidant levels were found to be significantly reduced in both Group I and Group II in comparison to the control group. Group II showed significantly reduced level of GR in comparison to Group I. The MN count was significantly increased in Group II in comparison to Group I. The MN counts showed an inverse correlation to the activities of the antioxidant enzymes. Greater activities of antioxidant enzymes correlated with decreased MN counts.

Conclusions:

Detection of MN in AN chewers with or without tobacco can be a useful biomarker for clinical screening procedures that may be used as a risk marker for oral cancer. It is important to increase the awareness programs to educate the public about the deleterious effects of AN chewing, emphasize on early intervention of AN chewing habit and thus prevent the development of oral cancer.
Artificial intelligence in brachytherapy for cervical cancer
Authors: Tian Xiufang , Li Cuihua , Hou Yong , Xie Jian , Song Meijuan , Liu Kun , Zhou Jing
Published: February 2023

Brachytherapy (BT) consists in the insertion of radioactive implants directly into the tissue through an applicator, in order to kill tumor cells. This is for the tumor tissue to receive a higher dose, whereas the surrounding normal tissues receive a lower dose of radiation because of the rapid fall of the dose. Because of the special anatomical position of the cervix, smaller organ mobility, and higher tolerable doses of radiotherapy in the vagina and uterus, BT has been most widely used to treat cervical cancer and is an important part of radical radiotherapy for this type of cancer. Furthermore, it is closely related to the prognosis of patients. However, the treatment process, including target area delineation, applicator reconstruction, plan design, and optimization, is time-consuming, which may lead to changes in patient's bladder filling or gastrointestinal peristalsis. Therefore, this not only yields a poor patient experience, but may also affect the accuracy of the treatment and prognosis. With the development of computer hardware, deep learning has been gradually applied in different fields and different networks have been developed to solve various problems. By combining deep learning technology with three-dimensional BT technology, the automation of BT planning can be realized, which, in turn, can significantly shorten the treatment time, alleviate the pain of the patient, and improve treatment efficacy. This article summarizes and gives the prospects of the application of artificial intelligence in the context of BT for cervical cancer.
Chinese expert consensus on the nursing management of the totally implantable venous access device
Authors: Xu Yin , Fei Xiao-yan , Xue You-hua , Wang Xue-mei , Wang Xiao-yan , Zheng Yu-ting , Chen Ke , He Jing-jing , Ren Xiu-hong , Pan Lei , Wang Ling , Qian Duo , Li Wei-feng , Liang Yan , Fang Yan , Huang Xu-fang , Li Chun-hong , Chen Dong-ping , Wang Yang , Wen Li-hong , Zhang Yong-hui , Zheng Yan , Song Hui , Lin Ying-chun , Zhang Qi , Yang Ru-mei , Wang Zhong-min
Published: February 2023

The totally implantable venous access device (TIVAD) has been widely used in clinical nursing work in China. The use of TIVAD has significantly improved the safety of venous access and reduced the pain caused by a repeated puncture; however, it may also bring with it varying degrees of complications associated with the long-term insertion of TIVAD and the maintenance quality of the venous access. Standard maintenance of the venous access for TIVAD is very important for reducing complications and improving the efficacy and patient's quality of life. This consensus briefly describes the fundamental knowledge and operating procedures of TIVAD while focusing on the evaluation and management of perioperative nursing, the observation and treatment of complications, the operation methods, and precautions for maintenance of venous access, as well as health education. This agreement seeks to standardize the nursing care of TIVAD patients in China.
Oncolytic virotherapy against the tumor microenvironment and its potential in pancreatic cancer
Authors: Zhang Yalei , Li Ye , Chen Kun , Qian Ling , Wang Peng
Published: February 2023

Emerging evidence has revealed the critical role of the tumor microenvironment (TME) in tumor progression, angiogenesis, metastasis, and immunosuppression. Oncolytic viruses (OVs), a versatile therapeutic agent that targets both cancer cells and the TME, have emerged as a promising candidate for antitumor therapy. Strategies of manipulating OVs against the TME include normalization of the tumor vasculature, decomposition of the tumor stroma, and reversion of the immunosuppressive microenvironment. In pancreatic cancer, desmoplastic stroma comprises up to 80% of the tumor mass, accompanied by hypovascularity and profound immunosuppression, conferring a particularly important role to TME-targeted oncolytic virotherapy. Mechanisms and supporting evidence of OVs reversing the tumor-privileged TME and applications of TME-targeted OVs for pancreatic cancer are summarized in this review.
Laparoscopic-assisted surgery versus open surgery for transverse colon cancer
Authors: Tamagawa Hiroshi , Numata Masakatsu , Aoyama Toru , Kazama Keisuke , Maezawa Yukio , Atsumi Yosuke , Hara Kentaro , Kano Kazuki , Komori Keisuke , Kawahara Shinnosuke , Yukawa Norio , Sawazaki Sho , Saeki Hiroyuki , Godai Teni , Rino Yasushi , Masuda Munetaka
Published: February 2023

Introduction:

Previous randomized controlled trials demonstrated similar oncological outcomes between laparoscopic-assisted (LA) and open (OP) colectomy; however, patients with transverse colon cancer were not analyzed. The aim of this study was to confirm the oncological safety and the advantages of the short- and long-term results of LA surgery for transverse colon cancer in comparison to OP surgery.

Materials and Methods:

The study data were retrospectively collected from the databases of four hospitals. Patients with transverse colon cancer who underwent LA or OP R0 or R1 resection were registered.

Results:

Among the 204 patients, 149 underwent OP colectomy and 55 underwent LA colectomy. The median follow-up period was 43 months. The rate of conversion to OP resection was 7.3%. The 5-year overall survival rate of the LA group was higher than that of the OP surgery group for all-stage patients (97.5% vs. 91.1%, P = 0.108), and it was similar in Stage II and Stage III patients (94.1% vs. 94.2%, P = 0.510). The LA group had significantly lower blood loss and a significantly longer operative time in comparison to the OP surgery group. Furthermore, the postoperative hospital stay was significantly shorter (9 vs. 13 days, P = 0.001) and the incidence of Grade ≥III complications was lower in the LA group (3.7% vs. 14.8%, P = 0.031).

Conclusion:

We concluded that LA surgery for transverse colon cancer is oncologically safe and yields better short-term results in comparison to OP surgery.
Formulation and Evaluation of Levofloxacin and Betamethasone Ophthalmic Emulgel
Authors: Sabry Hiba Sabah , Al-Shohani Athmar Dhahir Habeeb , Mahmood Sura Zuhair
Published: February 2023

Objective:

Drug delivery to ocular tissues is challenging due to rapid removal of instilled drug due to low resident time in ocular tissues. The aim of the study was to formulate an ophthalmic emulgel that delivers two drugs (betamethasone sodium phosphate [BSP] and levofloxacin). The new combination will allow the simultaneous administration and extended release of the two drugs which potentially improve resident time in ocular tissues, patient compliance, and adherence to treatment.

Materials and Methods:

Formulations containing different gelling agents at different concentrations were prepared to choose the optimum combination regarding physical properties and release. The emulgel formulations F1, F2, F3, and F4 were made using gelling agent 1% and 2% xanthan gum, 1% carbopole 934, and 2% methyl cellulose, respectively. F5 was formulated using 2% methyl cellulose with double the amount of poloxamer 188 as emulsifying agent. All the formulations were examined regarding their physical appearance, pH, viscosity, drug content, and in vitro drug release. The optimum formula was also examined for antibacterial activity.

Results:

The results demonstrated that F5 was the optimum formulation having a proper physical characteristics and release profile of both drugs, 96% and 90% for BSP and levofloxacin, respectively, compared to other formulations and commercial eye drops.

Conclusion:

Simultaneous and extended release of the two drugs was achieved using one formulation of emulgel. The ability to deliver hydrophilic and hydrophobic drug through the same formulation without the need to use two drops will improve patient compliance and hence patient adherence to treatment.
Effect of Pharmacist-Led Intervention on Progression of Diabetic Complications at Two Tertiary Care Hospitals of Malaysia
Authors: Iqbal Muhammad Zahid , Khan Amer Hayat , Sulaiman Syed Azhar Syed , Ibrahim Aznita , Azmi Nor Shaffinaz Binti Yusoff , Iqbal Muhammad Shahid , Al-Saikhan Fahad I. , Khan Salah-Ud-Din , Saad Eldowaik Mohamed Salah
Published: February 2023

Background and Objective:

Diabetes mellitus is a chronic disease which can lead to different complications in patients if not treated properly. An appropriate intervention from health care providers is needed to stop and decrease the progression of diabetic complication in diabetic patients. This study aimed to measure the effect of pharmacist intervention on improvement in sign and symptoms and progression of diabetic complications in diabetic patients.

Methodology:

Diabetic patients were randomly selected and divided into two groups from two tertiary care hospitals. Control group contained those 200 patients who were receiving usual treatment from hospitals. In contrast, the intervention group included those 200 patients who were receiving conventional treatment from hospitals together with separate counselling sessions with pharmacists from Diabetes Medication Therapy Adherence Clinic departments. The study continued for 1 year and two follow-up visits for both groups. A prevalidated data collection form was used to measure the improvement in sign and symptoms and progression of diabetic complication in diabetic patients. Statistical Package for the Social Sciences (SPSS) version 24 was used to analyze the data.

Results:

The average hemoglobin A1c (HbA1c) values decreased up to 1.43% in the control group and 2.82% in the intervention group. The intervention group showed significant improvement in HbA1c between groups (P < 0.05). The results of univariate and multivariate regression analysis showed that a statistically significant (P < 0.001) improvement was observed in all the predictors of diabetic complications among in the intervention group when compared with the control group.

Conclusion:

Statistically significant reduction in the sign and symptoms of diabetic complications was observed in the intervention group at the end of 1 year. The progression of diabetic neuropathy was significantly reduced in the pharmacist intervention group.
Quantitative homogenization for combustion in random media
Authors: Zhang Yuming Paul , Zlatoš Andrej
Published: February 2023

We obtain the first quantitative stochastic homogenization result for reaction–diffusion equations, for ignition reactions in dimensions

d\le 3

that either have finite ranges of dependence or are close enough to such reactions, and for solutions with initial data that approximate characteristic functions of general convex sets. We show an algebraic rate of convergence of these solutions to their homogenized limits, which are (discontinuous) viscosity solutions of certain related Hamilton–Jacobi equations.
Hopf monoids, permutohedral cones, and generalized retarded functions
Authors: Norledge William , Ocneanu Adrian
Published: February 2023

The commutative Hopf monoid of set compositions is a fundamental Hopf monoid internal to vector species, having undecorated bosonic Fock space the combinatorial Hopf algebra of quasisymmetric functions. We construct a geometric realization of this Hopf monoid over the adjoint of the (essentialized) braid hyperplane arrangement, which identifies the monomial basis with signed characteristic functions of the interiors of permutohedral tangent cones. We show that the indecomposable quotient Lie coalgebra is obtained by restricting functions to chambers of the adjoint arrangement, i.e., by quotienting out the higher codimensions. The resulting functions are characterized by the Steinmann relations of axiomatic quantum field theory, demonstrating an equivalence between the Steinmann relations, tangent cones to (generalized) permutohedra, and having algebraic structure internal to species. Our results give a new interpretation of a construction appearing in the mathematically rigorous formulation of renormalization by Epstein–Glaser, called causal perturbation theory. In particular, we show that operator products of time-ordered products correspond to the H-basis of the cocommutative Hopf monoid of set compositions, and generalized retarded products correspond to a spanning set of its primitive part Lie algebra.
The Arens-Michael envelopes of the Jordan plane and $U_q(\mathfrak{sl}(2))$
Authors: Pedchenko Dmitrii
Published: February 2023

The Arens-Michael functor in noncommutative geometry is an analogue of the analytification functor in algebraic geometry: out of the ring of “algebraic functions” on a noncommutative affine scheme, it constructs the ring of “holomorphic functions” on it when viewed as a noncommutative complex analytic space. In this paper, we explicitly compute the Arens-Michael envelopes of the Jordan plane and the quantum enveloping algebra

U_q(\mathfrak{sl}(2))

of

\mathfrak{sl}(2)

for

|q|=1

.
Homotopy Rota–Baxter operators and post-Lie algebras
Authors: Tang Rong , Bai Chengming , Guo Li , Sheng Yunhe
Published: February 2023

Rota–Baxter operators and the more general

\mathcal{O}

-operators, together with their interconnected pre-Lie and post-Lie algebras, are important algebraic structures, with Rota–Baxter operators and pre-Lie algebras instrumental in the Connes–Kreimer approach to renormalization of quantum field theory. This paper introduces the notions of a homotopy Rota–Baxter operator and a homotopy

\mathcal{O}

-operator on a symmetric graded Lie algebra. Their characterization by Maurer–Cartan elements of suitable differential graded Lie algebras is provided. Through the action of a homotopy

\mathcal{O}

-operator on a symmetric graded Lie algebra, we arrive at the notion of an operator homotopy post-Lie algebra, together with its characterization in terms of Maurer–Cartan elements. A cohomology theory of post-Lie algebras is established, with an application to 2-term skeletal operator homotopy post-Lie algebras.
Punctual characterization of the unitary flat bundle of weight one PVHS and application to families of curves
Authors: González-Alonso Víctor , Torelli Sara
Published: February 2023

In this paper, we consider the problem of pointwise determining the fibres of the flat unitary subbundle of a polarized variation of Hodge structures (PVHS) of weight one. Starting from the associated Higgs field, and assuming the base has dimension 1, we construct a family of (smooth but possibly non-holomorphic) morphisms of vector bundles with the property that the intersection of their kernels at a general point is the fibre of the flat subbundle. We explore the first one of these morphisms in the case of a geometric PVHS arising from a family of smooth projective curves, showing that it acts as the cup-product with some sort of “second-order Kodaira–Spencer class” which we introduce, and check in the case of a family of smooth plane curves that this additional condition is non-trivial.
Jezus kot coprnik
Authors: Bevc Benjamin
Published: February 2023

Tavmaturško in eksorcistično delovanje Jezusa iz Nazareta so nekateri nasprotniki krščanstva interpretirali kot čarovništvo. To velja zlasti za pamflet Resnični govor, nastal okoli leta 180, v katerem srednjeplatonski filozof Kels trdi, da naj bi bil Jezus γόης, se pravi coprnik, čarovnik najslabše vrste. Na osnovi ohranjenih fragmentov Resničnega govora članek najprej predstavi Kelsove obtožbe coprništva, nato pa se osredotoči na Ori­genovo zavrnitev teh obtožb v delu Zoper Kelsa. Medtem ko Kels čudodelniško delovanje istoveti s coprništvom, pa Origen predstavi vrsto kriterijev, ki omogočajo razločevanje med njima. Obstoj tovrstnih kriterijev po eni strani kaže, da Origen vsaj posredno priznava ambivalentnost čudodelniškega delovanja, po drugi strani pa razodeva, da je pojem čarovništva izrazito relacionalen.
Trash Streaming: Characteristics and Methodological Guidelines
Authors: Cyrek Barbara , Popiołek Malwina
Published: February 2023

Livestreaming is an opportunity to participate in digital social life, both for streamers and their audience. This participation is associated with the possibility of spreading content considered as socially harmful. Although trash streams have been popular in Central Europe for several years, they are still not fully characterized. Previous studies define them rather operationally – for the needs of a given analysis. This study fills that gap. Based on long-term observation of trash streamers activity and review of the literature and press reports, the authors provide a comprehensive description of trash streams pointing to differences in nomenclature used in Poland and worldwide. The article also provides methodological guidelines for the analysis of trash streams. The authors developed these guidelines on the basis of the analysis of the literature and their own research experience.

Słowa kluczowe: social pathology, online com
From Braille Code to Smart Book Readers: Technology as a Tool for Reading Emancipation of the Visually Impaired Persons
Authors: Albin Kamila
Published: February 2023

This paper illustrates how, over the course of the last two centuries, the autonomous access of the visually impaired to reading material has expanded. The author coins the term “reading emancipation” to describe these processes. She illustrates it by referring to her own research involving in-depth interviews with the visually impaired readers regarding the use of various forms of books, such as books printed in Braille, talking books and e-books. The author also traces the historical background of the transformation of alternative book formats, from the development and spread of Braille code to digital books. The description of the evolution of book formats is set against the background of the transformations taking place in Europe with a strong emphasis on the impact of these transformations on Poland.
¿Cómo se juzga a las chicas en el sistema de justicia juvenil español? Un estudio exploratorio a partir de datos primarios
Authors: Páez-Mérida Ana , Montero Molera Alicia
Published: February 2023

Algunos estudios apuntan que las mujeres reciben un trato benévolo por parte de los jueces, mientras que otros muestran una respuesta penal más dura contra ellas. No obstante, la mayoría de las investigaciones han sido realizadas en el ámbito internacional y abordan esta cuestión en el sistema de penal de adultos, desconociendo qué sucede en el sistema de justicia juvenil. El objetivo de este trabajo es conocer cuál es la respuesta penal que dan los jueces a esta delincuencia y si existen diferencias por sexo. Para ello, se ha llevado a cabo una investigación exploratoria en la que se han revisado los expedientes de reforma de 522 menores enjuiciados en tribunales españoles. Si bien se han encontrado algunas diferencias en el tipo y la duración de las medidas impuestas según el sexo de los menores, estas podrían ser legítimas debido a que las chicas cometen delitos leves y son menos reincidentes.
Pasteurellosis: A significant bacterial disease in rabbit production
Authors: Abd El-Ghany Wafaa A.
Published: February 2023

Rabbits are susceptible to various respiratory affections. Pasteurellosis, caused by P. multocida, is regarded as one of the most important bacterial diseases of rabbits. The disease is characterised by chronic mucopurulent respiratory affection (snuffles) or more acute and subacute bronchopneumonia leading to high mortality and severe devastating losses in rabbit production. Moreover, pasteurellosis is associated with septicaemia, abscesses, otitis media, and nervous and reproductive disorders. P. multocida is widely distributed worldwide and mostly affects rabbits from 4 to 8 weeks of life. Infection with P. multocida usually occurs by indirect or direct contact, chiefly via aerosol. Moreover, the presence of other stressors can aggravate the severity of infection. The gold standard for the diagnosis of pasteurellosis is traditional isolation and identification methods. However, molecular techniques are used now for rapid detection of P. multocida and its virulence genes. Prevention is based on the application of hygienic methods, vaccination, and treatment using various antimicrobials. This review article gives an overview of pasteurellosis in rabbits regarding disease incidence, susceptibility and transmission, signs and lesions, laboratory diagnosis, and the prevention and control methods.
SOCIO-PSYCHOLOGICAL CONSEQUENCES OF SOCIAL MEDIA ON RURAL ADOLESCENTS
Authors: Kaur Gurpreet
Published: February 2023

Today, social media is an inseparable part of individual’s life. It is capable of transforming behavior, beliefs, skills, social insects and other things. Social media offers new skills and ways to participate in the world. This paper explores the psychological effects of social media on rural adolescents in Sri Muktsar Sahib and Mansa District of Punjab. The total sample size comprised of 120 respondents from all the eight villages were selected randomly. This paper shows that more than half (52.5%) of the respondents demanded expensive phones, tablets from their parents to playing video games. Most of the respondents (49.16%) used social media when nobody around them, ninety five percent of the respondents were used smart phone, Teenagers mostly use social media for entertainment.
REGULATION OF LEGAL MIGRATION FROM GEORGIA TO EU COUNTRIES AND INTEGRATION INTO THE LABOR MARKET
Authors: Dudauri Tamar
Published: February 2023

Migration processes have become not only an important factor in modern international relations, but also have a serious impact on the state's domestic policy. In addition to combating illegal migration, protecting borders and providing asylum, an integral part of migration policy is also regulation of legal migration channels, including labor migration. Effective management of legal migration is in the common interest of EU member states and the EU as a Union. The paper presents a comprehensive analysis of the stages and principles of the formation of the supranational component of the regulation of legal migration in the European Union. The author pays special attention to the political and legal component, methods and tools of migration regulation in the European Union. The assessment of the current situation of the common migration policy of the European Union is of interest for the integration processes and the future development of the European Union.
Software Defect Prediction Using Machine Learning Techniques
Authors: Cauvery G , DhinaSuresh D
Published: February 2023

Software defect prediction provides development groups with observable outcomes while contributing to industrial results and development faults predicting defective code areas can help developers identify bugs and organize their test activities. The percentage of classification providing the proper prediction is essential for early identification. Moreover, software- defected data sets are supported and at least partially recognized due to their enormous dimension.
Incorporating Social Justice Education into Teacher Education: A Book Review of Communicating Social Justice in Teacher Education: Insights from a Critical Classroom Ethnography
Authors: Hidayat Angga
Published: February 2023

Aubrey Huber's book is of great value to aspiring and current educators alike, providing a comprehensive analysis of how qualitative critical classroom ethnography can be applied to support social justice in the field of education. Through this text, readers will gain an understanding of the unique opportunity that classroom ethnography provides in terms of utilizing it as an actionable mechanism to respond to social injustices while balancing intertwined multiple perspectives. Teacher educators who use this text will obtain a deeper appreciation for the instrumental role qualitative research such as classroom ethnography plays in improving and reforming education. All in all, Huber’s text is an apt resource for anyone looking to integrate a critical lens and create meaningful social change in teacher education.
Improved Median Survival for Glioblastoma Multiforme Following Introduction of Adjuvant Temozolomide Chemotherapy
Authors: Back Michael F , Ang Emily LL , Ng Wai-Hoe , See Siew-Ju , Lim CC Tchoyoson , Chan SP , Yeo Tseng-Tsai
Published: February 2023

Introduction: The use of adjuvant temozolomide (TMZ) in patients managed with surgery and adjuvant radiation therapy (RT) for glioblastoma multiforme (GBM) has been demonstrated to improve median and 2-year survival in a recent large international multicentre study. To confirm this result in routine clinical practice, an audit of the management and outcome of patients with GBM at The Cancer Institute Radiation Oncology was performed.

Materials and Methods: All patients with GBM managed radically at The Cancer Institute Radiation Oncology from May 2002 to 2006 were entered into a prospective database. Patient, tumour and treatment factors were analysed for association with the outcome of median survival (MS). Survival was calculated using the Kaplan-Meier technique and correlation was assessed using Cox proportional hazards regression.

Results: Forty-one patients with GBM were managed with radical intent over the 4year period. The median age was 54 years and 66% were Eastern Cooperative Oncology Group (ECOG) 0-1 performance status. Macroscopic, subtotal and biopsy alone procedures were performed in 61%, 29% and 10% of patients, respectively. The median time from surgery to RT was 26 days. Adjuvant TMZ was used in 44% of patients (n = 18). The MS of the total group was 13.6 months, with a 24% 2-year overall survival. The use of TMZ was associated with improved MS (19.6 versus 12.8 months; P = 0.035) and improved 2-year survival (43% versus 0%). A requirement of dexamethasone dose greater than 4 mg at the end of RT (P = 0.012) was associated with worse survival, but there was no association of MS with age, ECOG, tumour size or extent of surgery.

Conclusion: The median and 2-year survival outcomes are comparable to the results of the European Multicentre Study and justify the continued use of TMZ in routine clinical practice.

Key words: Adjuvant, Glioblastoma, Temozolomide
Association between Utilization of Personal Protective Equipment and Prevalence of Road Traffic Injuries amongst Motorcycle Users in Kibera Constituency, Nairobi County Kenya
Authors:   Mount Kenya University, A. Senaji Franklin Mike , Muhonja Dr. Faith ,   Mount Kenya University, Maathai Dr. Ronald ,   Mount Kenya University
Published: February 2023

Throughout the world, road traffic injuries (RTIs) are a vastly silent encroaching public health problem. Motorcyclists and pillion passengers are two of the most vulnerable road users worldwide. In Kenya, the annual incidence reports on RTIs amongst these groups had been on the rise in recent years. In 2017, 1,270 injuries were recorded while 2018 had 1,587 RTIs amongst these two groups. In 2019, 2,911 injuries were reported and 4,575 injuries in 2020. The purpose of the study was to assess the association between the utilization of Personal Protective Equipment (PPE) and the prevalence of Road Traffic Injuries (minor and major) amongst motorcycle riders in Kibera constituency, Nairobi County, Kenya. Specific objectives were to determine the prevalence of RTIs amongst motorcycle riders, to determine the level of PPE utilization amongst the motorcycle riders, to evaluate the association between the utilization of PPE and the severity of injury sustained by the riders, and to evaluate the effect size of the association between the utilization of PPE and the type of injury sustained by motorcycle riders. A cross-sectional analytical study design was used to gather both qualitative and quantitative data from the motorcycle riders in Kibera constituency. Questionnaires were used to gather information on injuries sustained from the local hospitals and clinics visited by the motorcycle riders in Kibera constituency. A checklist was used to gather data on the utilization of personal protective equipment by motorcycle users in Kibera constituency. The total number of registered motorcycles (2956) was subjected to Slovin’s formula (n)=N/(1+Ne^2) to obtain a representative sample of 353 motorcycle riders who participated in the study. Data was analyzed using SPSS V22 and MS-excel software. Data was subjected to bivariate analysis with crosstabs for case classification, Chi square to evaluate the association, and Cramer’s V to measure the effect size of the association. A 95 percent confidence level was used for the whole analysis of this study. The 0.05 level of significance was used throughout the study to test the significance of the association between PPE utilisation and severity of injury when an accident occurred. Utilisation of PPE was negatively associated with severity of injury. Further, while Helmet, Jacket, Heavy trousers and Gloves reduced severity of injury, Reflective vest and Boots were not significantly associated with severity of injury sustained by the Motorcycle riders.
LIFTING POTENTIAL DIFFICULTIES AMONG STUDENTS IN FOREIGN LANGUAGE CLASSES
Authors: Volnakova M.V.
Published: February 2023

A foreign language is a compulsory subject in all universities of our country, since in the modern world specialists in various activity fields need to work with documentation in a foreign language, study relevant content on the Internet relevant to the profession, and interact with foreign colleagues. Therefore, the problem of the effectiveness of teaching a foreign language is relevant for future specialists in completely different areas of activity. The overwhelming majority of students of Russian universities belong to the age category of "students", which is characterized by its own psychological characteristics. The object of the research are second-year students at the age of about 20, since it is at this age that the stage of maturation ends and the transition of personality to adulthood takes place. The success of mastering educational material is influenced by various individual characteristics, including character accentuations. A description of ways to remove such difficulties will improve the quality of teaching a foreign language and ensure the progress of all students. The purpose of the research is to describe methodological techniques. Using them a teacher will be able to remove potential difficulties in the classroom and increase the effectiveness of the educational process in student groups learning a foreign language. The research methods used are a theoretical analysis of scientific publications on the topic of research and monitoring of potential difficulties in the educational activities of students. In the process of teaching a foreign language to second-year students, several methodological techniques have been identified that make it possible to implement a differentiated approach in the classroom and achieve consistently high rates and positive grades at the end of the course. According to the author of the article, the removal of potential difficulties contributes to the development of professional competencies by students in a foreign language, and also creates a situation of success in the classroom and helps to overcome difficulties in the learning process.
Association of muscles length and strength with balance and functional status among children with diplegic spastic cerebral palsy
Authors: Afnan Zavata , Malik Arshad Nawaz , Jahan Saira , Ali Arshad
Published: February 2023

Objective: To determine the correlation of muscle length and muscle strength with balance and functional status among children with diplegic spastic cerebral palsy.
Method: The cross-sectional study was conducted from February to July 2021 at the Physical Therapy Department of Chal Foundation and Fatima Physiotherapy Centre, Swabi, Pakistan, and comprised children aged 4-12 years with diplegic spastic cerebral palsy. The strength of back and lower limb muscles was assessed through manual muscles testing. Lower limb muscle’s length, indicating tightness, was assessed using goniometer. Paediatric balance scale and gross motor function measure scale-88 were used to assess balance and gross motor function. Data was analysed using SPSS 23.
Results: Of the 83 subjects, 47(56.6%) were boys and 36(43.4%) were girls. The overall mean age was 7.31±2.02 years, mean weight was 19.71±5.45kg, mean height was 105.5±14cm and mean body mass index was 17.32±1.64 kg/m2. There was a positive and significant correlation of all the lower limb muscles’ strength with balance (p<0.01) and functional status (p<0.01). The correlation between the tightness of muscles and balance was significant and negative for all lower limb muscles (p<0.005). The correlation between the muscles’ tightness and functional status was negative and significant for all lower limb muscles (p<0.005).
Conclusion: Good muscle strength and appropriate flexibility of lower limb muscles enhanced functional status and good balance in children with diplegic spastic cerebral palsy.
Key Words: Balance, Cerebral palsy, Diplegic cerebral palsy, Functional status, Muscle length, Muscle strength.