bluuebunny/crossref_metadata_2025 huggingface dataset:
Transforming Growth Factor-β1 and Laminin-111 Cooperate in the Regulation of Expression of Interleukin-6 and Interleukin-8 in Synovial Fibroblasts
Authors:   Center for Regenerative Biology and Medicine (ZRM), Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany, Aicher Wilhelm K. , elka Tino F , Warstat Katrin ,   Center for Regenerative Biology and Medicine (ZRM), Center for Medical Research, University of Tubingen Medical School, Tubingen, Germany, Kluba Torsten , Mittag Falk ,   Department of Orthopaedic Surgery, University of Tubingen Medical Center (UKT), Tubingen, Germany, Hoberg Maik ,   Department of Orthopaedics and Trauma Surgery, KRI, Technical University, Munich, Germany, Klein Gerd ,   Section for Transplanation Immunology and Immunohematology, Center for Medical Research, University of Tubingen, Germany
Published: September 2023

In a recent study we showed that binding of synovial fibroblasts (SF) to laminin-111 (LM-111) in the presence of TGF-β1 induced a significant production of IL-16. Here we go on to investigate the regulation of IL-6 and IL-8 in SF by LM-111 and TGF-β1. Changes in steady state mRNA levels encoding the interleukins were investigated by quantitative RT-PCR. We screened for interleukin production by a multiplexed immunoarray and quantified it with ELISA. The biological activity of IL-6 and IL-8 was corroborated by B-lymphocyte proliferation and cell migration assays, respectively. Growth of SF on LM-111 in presence of TGF-β1 induced significant mRNA responses for IL-6 (mean 3.72-fold increase, ± 1.6, p<0.003) and IL-8 (mean 4.5-fold increase, ± 1.6, p<0.001). In the supernatants significantly elevated concentrations of IL-6 (mean 7.9 ± 5 ng/mL, p<0.005) and IL-8 (mean 73.0 ng/mL ± 51, p<0.05) were detected, and they were shown to be biologically active. Binding to LM-111 in the presence of TGF-β1 activates SF for expression of IL-6 and IL-8 and thus may contribute to synovial inflammation and to infiltration of leukocytes.
Application of Spatially Distributed Field of Electric Impulses for Correction of Angiogenesis in Ischemic Muscular Tissue
Authors:   Ural Federal University, Ekaterinburg, Russia, Kublanov V. S. ,   Institute of Medical Cell Technology, Ekaterinburg, Russia, Danilova I. G. , Goette I. F. ,   Institute of Immunology and Physiology of Ural Branch of Russian Academy of Sciences, Ekaterinburg, Russia, Shalyagin M. A. ,   Ural State Medical Academy, Ekaterinburg, Russia, Brykina I. A. ,   Institute of Medical Cell Technology, Ekaterinburg, Russia
Published: September 2023

Influence of spatially distributed field of electric impulses in a projection to cervical ganglions of the sympathetic nervous system on angiogenesis in ischemic muscular tissue of a rat's shin has been studied. It is revealed that blood supply of animals, influenced by the field, is restored through increase in quantity of capillaries in ischemic tissues, and number of products of endogenous intoxication is reduced.
Treatment of the Posterolateral Tibial Plateau Fractures using the Anterior Surgical Approach
Authors:   Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan (ROC), Hsieh Chih-Hsin
Published: September 2023

Background: Fracture of the posterolateral tibial plateau is relatively uncommon. While surgical treatment by the posterior approach is theoretically ideal, this approach is associated with numerous complications. We describe a series of fractures of the posterolateral tibial plateau treated by the anterior surgical approach. Methods: Fifteen patients with posterolateral tibial plateau fractures were included in this study. All patients were treated operatively using the anterior approach. The quality of fracture reduction was evaluated and functional results were estimated by the Hospital for Special Surgery knee scoring system. Results: The most common cause of fracture was a motor scooter accident (86%, 13 of 15 patients), which may have resulted in the protective front plate of the scooter hitting the knee in the flexion position, causing an axial compression and valgus force, resulting in the fracture of the posterolateral tibial plateau. The average knee motion after surgery was 0-124° of flexion and 14 out of 15 patients (93%) experienced satisfactory articular reduction. There were no postoperative neural or vascular injuries and no wound complications. The average Hospital for Special Surgery knee score was 92 (range, 74-98). Conclusions: In our series, with careful preoperative planning, the anterior approach for the surgical treatment of posterolateral tibial plateau fractures had no complications and was associated with satisfactory outcomes.
Socioeconomic and Demographic Factors Affecting Body Mass Index of Adolescents Students Aged 10-19 in Ambo (a Rural Town) in Ethiopia
Authors:   School of Public Health, Addis Ababa University, Ethiopia, Haidar Jemal , Yetubie Mesert ,   Oromia Health Bureau, Ethiopia, Kassa Hailu ,   Bowling Green State University, Bowling Green, Ohio, USA, Fallon Jr L. Fleming ,   Bowling Green State University, Bowling Green, Ohio, USA
Published: September 2023

Background: Body mass index (BMI) is a commonly used anthropometric measurement to estimate the level of nutritional indices (underweight/overweight) of adolescents and adults. Knowledge of the factors affecting BMI is essential for developing intervention programs. This study was conducted to measure BMI and determine the socioeconomic and demographic factors affecting the relative weight of adolescents living in rural districts in Ethiopia. Methods: A randomized cross-sectional study of 425 adolescent students living in the Ambo region of Ethiopia was conducted. A pre-tested questionnaire was used to collect the socioeconomic and demographic status of the participants. BMI (weight/height2, kg/m2) was measured and used as index of relative weight. Data were analyzed using SPSS version 15. A stepwise backward logistic regression analysis was applied to identify the major determinant abnormal weight of the adolescents while controlling for co-linearity. Results: The prevalence of underweight was 27.2% with male preponderance. The proportion of normal weight females was higher than that of males. There was no significant difference in the proportion of overweight males and females. Age, number of meals, parental education level, source of food, and number of cattle owned were correlated with being underweight. After adjusting for confounding variables only being a member of the younger age group (AOR=1.99; 95% CI=1.01 to 3.57), source of food (AOR=2.4; 95% CI=1.24 to 4.74), and a greater number of cattle owned (AOR=4.9; 95% CI=1.27 to 19.28 were positively correlated with being underweight. Conclusion: Younger age adolescents, those who come from homes with no or few cattle, and their parents purchased food were likely to be underweight. This study will help local governments, educators and community groups develop programs to assist underweight adolescents attending schools.
Lexis in Chinese-English Translation of Drug Package Inserts: Corpus-based Error Analysis and Its Translation Strategies
Authors:   Department of Foreign Languages, the Fourth Military Medical University, Xi'an, China, Yumei Zhou , Ying Lin
Published: September 2023

Error analysis (EA) has been broadly applied to the researches of writing, speaking, second language acquisition (SLA) and translation. This study was carried out based on Carl James' error taxonomy to investigate the distribution of lexical errors in Chinese-English (C-E) translation of drug package inserts (DPIs), explore the underlying causes and propose some translation strategies for correction and reduction of lexical errors in DPIs. A translation corpus consisting of 25 DPIs translated from Chinese into English was established. Lexical errors in the corpus and the error causes were analyzed qualitatively and quantitatively. Some examples were used to analyze the lexical errors and their causes, and some strategies for translating vocabulary in DPIs were proposed according to Eugene Nida's translation theory. This study will not only help translators and medical workers reduce errors in C-E translation of vocabulary in DPIs and other types of medical texts but also shed light on the learning and teaching of C-E translation of medical texts.
Upaya Meningkatkan Hasil Belajar Matematika Dengan Menggunakan Model Pembelajaran Kooperatif Tipe Example Non Example Pada Siswa Kelas XII SMAS Guppi Samata Gowa
Authors: Nur Aisyah  , Azwan Anwar
Published: September 2023

This research is classroom action research (PTK) carried out at SMAS GUPPI Samata, Gowa Regency which aims to improve mathematics learning outcomes by using the Example Non Example type cooperative learning model. The subjects of this research were class XII students with a total of 26 students. Data collection was carried out using learning outcomes tests. The collected data was analyzed using quantitative and qualitative analysis. The research results showed that the average score of student learning outcomes in cycle I reached an average of 82.38 and in cycle II reached an average of 86.15. The standard deviation in cycle I was 5.721 and in cycle II was 4.315. Based on the category of completeness of learning outcomes used, the score obtained for students' mathematics learning outcomes which were categorized as complete in cycle I was 73.07% and in cycle II it increased to 100%. From these results it can be concluded that there has been an increase in mathematics learning outcomes by using the Example Non Example type cooperative learning model.
Penerapan PSAK No 16 Dalam Perlakuan Akuntansi Aset Tetap Pada Sekolah Smk Pariwisata Imelda Medan
Authors: HUTAGALUNG DINA MARGARETHA , Rajagukguk Thetty Surienty , Fauziah Fauziah
Published: September 2023

Aset tetap merupakan aset berwujud yang mempunyai masa atau periode manfaat lebih dari satu tahun, yang digunakan untuk kelancaran operasional sekolah. Dalam hal memaksimalkan peran tersebut sangat dibutuhkan kebijakan yang benar dan tepat pada pengelolaan aset tetap sekolah. Maka saat mengambil keputusan akan sangat membutuhkan alat informasi mengenai aset tetap salah satunya yaitu berdasarkan PSAK No.16. Tujuan penelitian ini yaitu untuk mengetahui Penerapan PSAK No.16 Dalam Perlakuan Akuntansi Aset Tetap Pada Sekolah Smk Pariwisata Imelda Medan.

            Penelitian ini menggunakan metode kualitatif deskriptif. Data yang didapat dalam penelitian ini berdasarkan wawancara, dokumentasi dan studi pustaka. Sumber data yang digunakan yaitu sumber data primer dan sekunder. Dari hasil yang disimpulkan bahwa SMK Pariwisata Imelda Medan dalam pengelolaan aset tetap tidak sesuai dengan PSAK No.16, yang dimana sekolah belum menerapkan salah satu metode penyusutan pada setiap aset tetap yang dimiliki sekolah. cara perolehan nya yaitu dengan pembelian tunai tetapi sekolah belum pernah membuat pencatatan atas pembelian tunai tersebut. Sekolah dalam menghentikan aset tetap dengan cara di biarkan dan diperbaiki kembali, namun sekolah tidak mencatat keuntungan dan kerugian aset tetap, sehingga hal ini tidak sesuai dengan PSAK No.16. Serta dalam hal penyajian sekolah belum membuat neraca atau menyajikan laporan keuangan.
PERBANDINGAN PERHITUNGAN HARGA POKOK PRODUKSI DENGAN MENGGUNAKAN METODE FULL COSTING DAN VARIABLE COSTING
Authors: Natasha Syarifah
Published: September 2023

Tujuan penelitian ini yaitu untuk mengetahui analisis perhitungan harga pokok produksi dengan menggunakan metode full costing dan variable costing pada CV. Berkat jaya baru Medan. Dengan pendekatan deskriptif berdasarkan karakteristik masalah yang diangkat oleh peneliti, maka penelitian ini diklasifikasikan sebagai penelitian kuantitatif deskriptif. Hasil penelitian menunjukkan bahwa perhitungan harga pokok produksi yang dibuat oleh perusahaan dengan metode variable costing perhitungannya hampir setara. Sementara pada perhitungan menggunakan metode full costing seluruh unsur biaya dimasukkan kedalamnya sehingga hasilnya jauh lebih akurat. Harga pokok produksi yang dihitung menggunakan metode  Perusahaan pada bulan April sebesar Rp 2.911.000. Harga pokok produksi yang dihitung menggunakan metode full costing pada bulan April sebesar Rp 2.927.000. Dan harga pokok produksi yang dihitung menggunakan meteode variable costing pada bulan April Rp 2.911.000. Selisih dari ketiga metode tersebut juga tidak jauh berbeda. Maka dari itu, metode full costing lebih baik jika digunakan oleh perusahaan untuk menentukan harga jual produk karena lebih mencakup seluruh unsur biaya dan sudah sesuai dengan perhitungan kaidah akuntansi biaya. Sehingga harga pokok produksi akan lebih tepat dan tentunya harga jual akan lebih tetap pula, serta hal ini dapat lebih meningkatkan laba atau keuntungan bagi perusahaan CV. Berkat Jaya Baru Medan.
Analisa Penerapan Psak No 16 Tentang Akuntansi Aset Tetap Pada Dinas Ketenaga Kerjaan Provinsi Sumatera Utara
Authors: Maranatha Silaban Mustika , Surienty Rajagukguk Thetty , Fauziah Fauziah
Published: September 2023

Aset adalah harta atau kekayaan yang ada di suatu perusahaan maupun Pemerintahan.Dinas Ketenagakerjaan Provinsi Sumatera Utara memiliki banyak asset yang digunakan dalam kegiatan operasional sebagai sarana dan prasarana dalam melayani masyarakat umum.Dilakukannya penelitian ini bertujuan untuk mengetahui apakah aset tetap yang ada di Dinas Ketenagakerjaan Provinsi Sumatera utara sesuai Dengan Psak No 16.Perhitungan penyusutan yang dilakukan Dinas Ketenagakerjaan Provinsi Sumatera Utara menggunakan metode garis lurus.Melakukan penelitian dengan pendekatan deskriptif berdasarkan karakteristik penerapan aset tetap sesuai psak no 16,maka penelitian ini dikelompokkan sebagai penelitian kuantitatif deskriptif.Data yang dipakai untuk penelitian ini yaitu data primer dimana data dikelola langsung dari Dinas Ketenagakerjaan Provinsi Sumatera Utara dalam bentuk observasi, dokumentasi dan wawancara dan data yang telah didapatkan diolah terlebih dahulu untuk menjadi informasi penelitian.

Hasil dari penelitian yang dilakukan yaitu Aset tetap yang ada di Dinas Ketenagakerjaan Provinsi Sumatera Utara jelas sesuai dengan Psak No 16. Disnaker Provinsi Sumatera Utara telah membuat pencatatan asset tetap,perolehan,pengakuan,pengeluaran,penyusutan,penghentian,dan penyajian asset tetap kedalam laporan CaLk.Maka dari itu dilakukan perbandingan (analisa) antara Dinas Ketenagakerjaan Provinsi Sumatera Utara yang di harapkan sesuai dengan psak no 16.namun, Dinas Ketenagakerjaan Provinsi Sumatera Utara tidak menyajikan secara jelas laporan CaLk dan tidak terjadi pelelangan asset.
Analisis Perhitungan Harga Pokok Produksi Dalam Menentukan Harga Jual
Authors: Maimuna Yuni , R Rusmayanti , Supriaddin Nofal
Published: September 2023

Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis perhitungan harga pokok produksi dalam menentukan harga jual. Variabel dalam penelitian ini terdiri dari Perhitungan Harga Pokok Produksi dan Harga Jual. Teknik pengumpulan data dalam penelitian ini melalui wawancara dan dokumentasi. Informan dalam penelitian ini yaitu Bendahara dan Bagian Kepala Produksi CV Fariz Karya Mandiri. Analisis data yang digunakan adalah deskriprif kualitatif. Hasil penelitian menunjukkan bahwa Perhitungan harga pokok produksi dengan menggunakan metode full costing memperoleh hasil yang sama dengan metode perusahaan Sedangkan dengan menggunakan metode variable costing memperoleh nilai yang lebih rendah dibandingkan metode perusahaan dan full costing. Menurut perhitungan metode perusahaan dan metode full costing sebesar Rp1.734.381.200, sedangkan metode variable costing sebesar Rp1.158.967.200. Perbedaan perhitungan harga pokok produksi tentu akan berpengaruh dalam penentuan harga jual produk. Dimana harga jual es balok dengan metode perusahaan sebesar Rp17.000 perbalok dengan melihat yang ada dipasaran dan harga jual metode full costing sebesar Rp15.471 perbalok sedangkan harga jual metode variable costing sebesar Rp10.337 perbalok.
Sistem Aplikasi Perpustakaan pada Politeknik Ganesha Medan
Authors: Hasibuan Riski
Published: September 2023

Sistem di perpustakaan Politeknik Ganesha Medan menggunakan Microsoft Excel. Kelemahan dalam sistem pepustakaan sekarang yaitu pustakawan kesulitan dalam pencarian buku, pemeriksaan buku ketika pengembalian, pembuatan laporan dan lain sebagainya.

Metode penelitian yang digunakan oleh penulis yaitu dengan observasi dan wawancara tidak terstruktur. Dalam melakukan observasi, penulis mengambil sample data di tempat penelitian yaitu perpustakaan Politeknik Ganesha Medan berupa contoh laporan daftar buku, peminjaman dan pengembalian. Wawancara tidak terstruktur yang penulis lakukan yaitu menanyakan data yang diperlukan dalam penyimpanan buku, pengembalian, peminjaman, aturan dalam peminjaman, sanksi bila terlambat mengembalikan buku dan pembuatan laporan.

            Berdasarkan hasil penelitian, sistem aplikasi perpustakaan ini dapat mempermudah pustakawan dalam melakukan pekerjaannya seperti pencarian data buku lebih cepat, informasi mengenai peminjaman dan pengembalian buku cepat diperoleh dan laporan yang dihasilkan lebih akurat. Sistem ini masih memiliki keterbatasan-keterbatasan seperti tidak tersedianya layanan untuk backup database dan pembuatan laporan yang tidak menggunakan grafik.
Perancangan Dan Pembuatan Website Forum Lembaga Dakwah Kampus Al-Hikmah
Authors: Sundari Sundari
Published: September 2023

Setelah terbentuknya LDK Al-Hikmah, semua kegiatan tanya jawab antara mahasiswa dan masyarakat tentang Agama islam dan Komputer dilakukan melalui pertemuan di suatu tempat yang telah ditentukan. Hal ini kurang efektif karena masih banyak mahasiswa maupun masyarakat tidak hadir dikarenakan terbentur oleh waktu mereka.

            Metode penelitian yang digunakan oleh penulis yaitu dengan observasi dan wawancara tidak terstruktur. Dalam melakukan observasi, penulis mengambil sample data di tempat penelitian yaitu perpustakaan Politeknik Ganesha Medan berupa contoh laporan daftar buku, peminjaman dan pengembalian. Wawancara tidak terstruktur yang penulis lakukan yaitu menanyakan data yang diperlukan dalam penyimpanan buku, pengembalian, peminjaman, aturan dalam peminjaman, sanksi bila terlambat mengembalikan buku dan pembuatan laporan.

            Berdasarkan hasil penelitian, website forum yang akan di bangun ini diharapkan seluruh mahasiswa maupun masyarakat dapat berkomunikasi melalui media elektronik tanpa harus tatap muka langsung dan dapat dilakukan dimana saja.
Pembuatan Website Tanaman Hias UD. Rose Medan
Authors: Irwansyah Irwansyah
Published: September 2023

Hasil penelitian ini merupakan hasil penelitian yang membahas mengenai Pembuatan Website Tanaman Hias UD. ROSE MEDAN.Permasalahan dalam penelitian ini adalah pihak toko masih menggunakan cara manual dalam penyampaian informasi baik dilingkungan sekolah maupun ke masyarakat banyak, sehingga kemungkinan akan terjadi kesalahan-kesalahan yang kecil maupun besar. Sehingga dengan adanya permasalahan-permasalahan tersebut di atas dapat dirumuskan bagaimanakah membuat suatu Website dengan sistem komputerisasi yang dapat membantu pihak sekolah dalam penyampaian informasi. Jenis data yang digunakan adalah data primer dan sekunder. Metode pengumpulan data meliputi wawancara, observasi dan kepustakaan. Secara umum penelitian ini bertujuan untuk membantu pihak toko untuk membuat Website secara komputerisasi untuk meminimalisasikan kesalahan-kesalahan yang mungkin terjadi pada proses manual. Dari hasil penelitian ini dapat disimpulkan bahwa suatu  website ini dapat membantu pihak toko dalam penyampaian informasi sehingga menghasilkan informasi yang efektif dan efesien.
Perancangan Sistem Informasi Forum Lembaga Dakwah Pesantren Ibadurrahman
Authors: Guntur Surya
Published: September 2023

Perkembangan teknologi dari masa ke masa akan semakin canggih dan menjadi berita yang menarik untuk terus di ikuti. Dengan adanya perkembangan teknologi ini di gunakan manusia dalam memenuhi kebutuhannya seperti penggunaan gadget untuk komunikasi jarak jauh dan sebagai hiburan, internet yang berguna untuk mengetahui informasi luar dan berbagai pengetahuan, dan lain sebagainya. Bagaimana membuat suatu sistem agar dapat mempermudah proses diskusi atau tanya jawab antara santri dan masyarakat yang membahas tentang agama islam. Hasil penelitian di lapangan pada saat ini fasilitas website tidak hanya digunakan untuk memberikan informasi-informasi dari perusahaan, organisasi, pemerintah dan personal tetapi lebih dari itu website saat ini digunakan untuk sebagai tempat kegiatan forum tanya-jawab antar pemakai website. Dengan mengunakan Aplikasi Adobe Dreamweaver CS3 berbasis PHP, kita dapat membuat web forum sesuai yang kita inginkan dengan cepat dan mudah. Melalui website forum inilah Lembaga Dakwah Pesantren (LDP) ‘Ibadurrahman dapat mengembangkan Metode dakwah dengan bentuk yang interaktif dan berbeda dari sebelumnya.
Development of a Solar-Powered Integrated Wireless Soil Moisture Meter
Authors: Nwogwu Nathaniel A. , Chukwurah Gabriel E. , Ngerem Olivia M. , Ajala Oluwaseyi A. , Opafola Omobolaji T. , Ajibade Fidelis O. , Okereke Ngozi Anthony A.
Published: September 2023

In this study, we developed a solar-powered integrated wireless soil moisture meter that can easily measure in situ soil moisture, soil temperature, and hydrogen potential (pH) using nature's solar energy. Knowledge of soil moisture content and other relevant soil-specific parameters is essential for irrigation scheduling, fertilizer selection, and fertigation. Also, considering that the electricity supply in some developing countries is either erratic or unavailable, this research aims to bridge the gap in electricity availability and ease of measurement and integrate more soil-specific parameters. The sensor system was developed using the frequency domain (FD) technique for fast response. These parameters were measured sequentially at an interval of about 5 seconds, with the readings displayed simultaneously on a Bluetooth-connected device (e.g., an Android phone) located about 50 meters away from the developed system. The different sensors are classified and adequately labeled to identify the parameter to be measured. The performance evaluation carried out indicated a reasonably functioning device that is cost-effective. The results obtained showed that the system was resourceful as it not only measured the parameters of interest (soil moisture, temperature, and pH) but also gave a prompt response in measurement and transmission. Overall, the developed wireless soil moisture meter provides instantaneous data on pH, moisture, and temperature circulation across soil layers. The system is promising as it can be integrated into large-scale automated irrigation systems for agricultural lands.
Sustainable Use of Waste Banana Peel (Musa × sapientum L.) Powder for Enhancement of Nutritional Properties of Dark Chocolate
Authors: Singh Rattan , Deshpande Avadhoot Sanjay , Pallavi Anushka , Kamboj Vishal
Published: September 2023

Dark chocolate is a very popular confectionary product among children, made by combining cocoa (55%) with cocoa butter (7.5%) and sugar (42%) has high antioxidant, anti-inflammatory, and free-radical scavenging properties. Chocolates also have a high concentration of cocoa and flavanols contents which is very beneficial for human health. The nutritional value of the dark chocolate samples prepared was further enhanced by using unripe banana peel powder. The peel of banana fruit is a waste material, but it also has antioxidant, antibacterial, and antibiotic properties which encourages its use in industries like pharmaceuticals. So, after considering the nutritional value of unripe banana fruit peel, the powder of unripe banana peel was added to the dark chocolate in the concentration of 1, 3, 5, 7, and 9% to increase the nutritional value of dark chocolate. The premix powder containing iron, folic acid, and vitamin B12 was also added to the dark chocolate samples in the concentration of 2% in all the variants. The nutritional value of chocolate samples made by using unripe banana peel powder and premix increased significantly but the color of the product decreased significantly as the concentration of banana powder increased.
Menace of Tomato Leaf Miner (Tuta absoluta [Meyrick,1917]): Its Impacts and Control Measures by Nepalese Farmers
Authors: Ghimire Sudip , Chhetri Bidhya Poudel
Published: September 2023

A multi-site study was conducted in Kathmandu, Bhaktapur, Kavre, and Pokhara, Nepal, to assess the impact of Tuta absoluta and identify effective control measures from the farmers' perspective. A total of 480 tomato-growing households were randomly selected for the study. The pest posed a significant threat to tomato production, resulting in increased labor requirements (29.96%), increased expenditures on crop protection and control measures (62.18%), and significant yield losses of up to 85%. The results showed that the pest was ranked as the most important pest of tomatoes by the majority of respondents (88%), with the flowering stage being highly susceptible (99.73%). The study highlighted that the overuse of chemical pesticides disrupts integrated pest management practices, while all the respondents affected by T. absoluta used chemical and cultural control methods without using biological control methods due to a lack of knowledge. About 77.27% of the respondents used physical control methods. Among the control methods used, tomato leaf miner (TLM) bait (0.764) was rated as the most effective, followed by chemical pesticides (0.586) and sanitation (0.502). The research highlights the importance of raising awareness of integrated pest management strategies, including the use of biological control methods, for effective and sustainable management of T. absoluta. These findings will help improve pest management practices and support the long-term sustainability of tomato production in Nepal.
A Study on Comparative Assessment of Water Quality of Dal and Nigeen Lakes of Jammu and Kashmir, India
Authors: Ahamad Faheem , Sharma Arun Kumar , Tyagi Sandeep Kumar
Published: September 2023

The lakes of the Kashmir valley, India are under continuous pressure due to increasing anthropogenic activities. In the present study, an attempt has been made to monitor the quality of two important lakes (Dal and Nigeen) of Jammu and Kashmir (J&K), India. These lakes hold significant ecological, cultural, and economic value, attracting many tourists and serving as vital sources of fresh water for local communities. Five sampling sites were selected in the study area, out of which three are in Dal Lake and two in Nigeen Lake. A comparison of the water quality of both lakes was made in the present investigation based on selected physicochemical parameters like water pH, conductivity (EC), dissolved oxygen (DO), biochemical oxygen demand (BOD), chemical oxygen demand (COD), chloride (Cl-), sulfate (SO42-), nitrate (NO3-) and phosphate (PO43-). The results revealed that the value of most of the parameters was higher in Dal Lake (BOD, EC, COD, and PO43-) while some parameters were found higher in Nigeen Lake (NO3-, DO, Cl- and SO42-). The student t-test showed significant differences (p < 0.05) between the means of most of the studied parameters of both the lake except EC and NO3-. Although all the parameters were within the limits if the trend of pollution continues, then the water quality of both lakes will become unfit for aquatic plants, animals, and tourist activities also. This study highlights the urgent need for effective water management strategies and conservation efforts to preserve the water quality of Dal and Nigeen Lakes.
DESAIN MEDIA PROMOSI COASTER UNTUK BERDAYA DALAM KETERBATASAN BERSAMA DIFABEL DI YAYASAN BUNGA BALI
Authors: Firdaus Adam , Arsa I Ketut Sida , Julianto I Nyoman Larry
Published: September 2023

Sebagai pusat rehabilitasi dan pemberdayaan sosial, Yayasan Bunga Bali memberikan pelatihan keterampilan seperti menjahit, memasak, melukis, pelatihan komputer, menari dan pelatihan lainnya. Namun salah satu bentuk usaha pelayanan tersebut adalah Yayasan Bunga Bali menyediakan sarana dan prasaran berupa rumah produksi kerajinan dari kayu, dan biasa digunakan sebagai tempat pelatihan keterampilan membuat kerajinan kayu sekaligus sebagai sarana pemberdayaan ekonomi bagi penyandang disabilitas, yang diberi nama Bunga Bali Craft. Meskipun pandemi COVID-19, pemberian pendampingan dari akademik masih diberi kesempatan untuk memberikan pelayanan pelatihan vokasional atau keterampilan dan pemberdayaan ekonomi di Bunga Bali Craft melalui kegiatan pelatihan keterampilan membuat coaster sebagai produk prototipe Bunga Bali Craft sebagai upaya untuk mempromosikan kembali produk-produk hasil tangan teman-teman difabel di Yayasan Bunga Bali. Coaster ini dibuat dengan tujuan untuk memperkenalkan bahwa teman-teman difabel di Bunga Bali Craft mampu membuat produk selain mainan kayu, tentunya dengan memperhatikan produk, cara promosi dan pemasaran, dan segmentasi pasar.
MENINGKATKAN KEMAMPUAN SISWA DALAM LITERASI DAN NUMERASI SERTA ADAPTASI TEKNOLOGI DI SMP NEGERI 2 AEK KUASAN MELALUI PROGRAM KAMPUS MENGAJAR ANGKATAN 3
Authors: Manalu Mega Ferawaty , Siahaan Mian , Pardede Sanggam , Marbun Yanti Maria Rosmauli , Yetti Yetti
Published: September 2023

Program Kampus Mengajar Angkatan III yang merupakan salah satu bentuk pelaksanaan Merdeka Belajar Kampus Merdeka (MBKM) yang berupa asistensi mengajar untuk memberdayakan mahasiswa dalam membantu proses pembelajaran di Sekolah Dasar dan Sekolah Menengah  di berbagai Desa/Kota, salah satunya adalah  di SMP Negeri 2 Aek Kuasan yang beralamat di Desa Alang Bonbon, Kecamatan Aek Kuasan, Kabupaten Asahan, Sumatera Utara. Pada program ini, mahasiswa yang terlibat memiliki tanggung jawab dalam membantu pihak sekolah pada proses mengajar dalam hal meningkatkan kedisplinan siswa dalam belajar, membantu adaptasi teknologi, dan membantu administrasi. Selain itu, mahasiswa memiliki tanggungjawab dalam memperbaiki karakter siswa dan meningkatkan minat belajar siswa selama masa pandemi ini.  

Hasil dari Program ini yakni sebagai penanaman empati dan kepekaan sosial pada diri mahasiswa terhadap permasalahan kehidupan masyarakat yang ada di sekitarnya; mengasah keterampilan berpikir dalam bekerja bersama lintas bidang ilmu dan ragam asal mahasiswa dalam menyelesaikan masalah yang dihadapi; mengembangkan wawasan, karakter dan soft skill mahasiswa; mendorong dan memacu pembangunan nasional dengan menumbuhkan motivasi masyarakat untuk berpartisipasi dalam pembangunan; serta meningkatkan peran dan kontribusi nyata perguruan tinggi dan mahasiswa dalam pembangunan nasional.
PEMBINAAN SENI TARI, TABUH, DAN MUSIK DI DESA BUWIT, KECAMATAN KEDIRI, KABUPATEN TABANAN
Authors: Widiastuti Ni Made Dian , Iriani Ni Wayan , Adipurwa A.A. Trisna Ardanari , Haryati Ni Made , Putra I Gede Gunadi , Kusuma Ni Putu Sandra Devindriati , Hartini Ni Putu
Published: September 2023

Tujuan kegiatan ini untuk mengajak generasi muda melestarikan seni tradisi di kalangan generasi muda, sekaligus sebagai terapi dalam menghindari pengaruh gawai digital yang menghambat kemampuan berkomunikasi generasi dini. Kegiatan dilakukan dalam jangka waktu enam minggu, dengan pertemuan tatap muka langsung. Teknik pengajaran dilakukan dengan pemberian contoh gerak dari pengajar yang kemudian ditirukan oleh peserta. Hasilnya generasi muda di Desa Buwit, menguasai tari Pendet, tari Rejang Dewa, tari Wirayuda, dan gamelan pengiring tari Pendet. Kemudian untuk anak-anak usia dini, telah berani untuk berkomunikasi dan mengungkapkan emosinya melalui kegiatan musik dan bernyanyi bersama. Kegiatan ini memberi semangat positif bagi masyarakat di Desa Buwit. Bagi orang tua, mereka sangat senang anak-anak mereka dapat melakukan kegiatan positif dan jauh dari gawai. Lalu yang terpenting adalah seni tradisi Bali dapat terus berlanjut.
PENDAMPINGAN PENCATATAN KEUANGAN PADA UMKM MIE ACEH SABANG MENGGUNAKAN APLIKASI CREDIBOOK
Authors: Prameswari Ardhia , Aisyah Siti , Occtavia Dindy Rizka , Bayani Luthfiah Nur , Rafli Mhd
Published: September 2023

Salah satu kunci kesuksesan UMKM yakni tidak terlepas dari bagaimana cara mereka melakukan pencatatan laporan keuangnnya. Jika pencatatan laporan keuangan dilakukan dengan baik dan tepat maka sangat mempermudah UMKM untuk memeriksa, mencegah dan melakukan evaluasi terhadap pencatatan transaksi yang telah dilakukan. Masih begitu banyak pelaku usaha UMKM yang melakukan pencatatan laporan keuangannya secara manual dikarenakan masih banyak pelaku UMKM yang buta teknologi atau tidak paham terhadap pengoperasian aplikasi yang ada di android. Tujuan dari kegiatan pengabdian yang dilakukan adalah untuk memperkenalkan kepada umkm mengenai aplikasi pencatatan keuangan yang dapat memudahkan para pelaku umkm sekaligus mengajarkan kepada mereka bahwa teknologi yang ada saat ini dapat membantu kegiatan usaha yang sedang dilakukan. Metode yang digunakan dalam kegiatan pengabdian kepada masyarakat ini adalah dengan memberikan penjelasan dan sosialisasi kepada UMKM Mie Aceh Sabang yaitu kepada owner usaha ini sendiri, penyampaian materi dilakukan oleh mahasiswa yang menjadi tim pelaksana pada penerapan aplikasi ini yang dimulai dari menjelaskan langkah awal menginstal software CrediBook serta menjelaskan fitur-fitur yang terdapat pada aplikasi CrediBook. Berdasarakan dari kegiatan pengabdian yang telah dilaksanakan maka didapatkan hasil yaitu: Pelaku Usaha Mie Aceh Sabang dapat melakukan pencatatan penjualan, pemasukan, pengeluaran, serta utang piutang dengan memanfaatkan aplikasi CrediBook, Pelaku Usaha Mie Aceh Sabang dapat mengoperasikan aplikasi pembukuan dengan mudah, dimana saja dan kapan saja, Pelaku Usaha Mie Aceh Sabang dapat memanfaatkan HP Android untuk melakukan pencatatan penjualan
The Investigation of Competitive Strategic Orientations of Export Companies in Suzhou City, China
Authors: Xu Xiwen , Kamkankaew Pongsiri , Thanitbenjasith Phithagorn , Wei Yu-Chen
Published: September 2023

Background and Aim: Exporting has different productivity effects on Chinese firms depending on their competitive strategic orientations. This research aims to investigate the opinion level of competitive strategic orientations of export companies in Suzhou City, China, and to study the guidelines of competitive strategic orientations of export companies in Suzhou City, China.
Materials and Methods: The quantitative research approach is going to be followed for this paper's investigation. 109 enterprises in Suzhou City that are involved in exporting will make up the entire sample size for the research. To collect information for this inquiry, a questionnaire was used as the primary tool of data collection. To do data analysis and determine the data that was given, statistical characteristics such as the mean and standard deviation were utilized.
Results: The study examines export enterprises in Suzhou, China, and finds moderate degrees of technology, learning, and market orientations. The aim is to improve these companies' competitive strategic orientations. Market orientation focuses on customer requirements, while competitive orientation fulfills competitors' dormant requirements. A learning orientation fosters a culture of learning, expansion, and innovation, with core values of commitment, open-mindedness, and shared goals.
Conclusion: The study analyzes Suzhou export enterprises' technology, learning, and market orientations, aiming to enhance competitive strategic orientations, customer requirements, and innovation through a learning culture. Suzhou City export companies should differentiate, educate employees, reduce costs, and implement quality manufacturing. Prioritize technological, product, process, and communication innovation, while focusing on long-term future growth and market-demanding strategies.
Research on the Construction of Technology-rich Classroom Learning Environment to Develop English Language Learning and Higher-order Thinking
Authors: Lei Juan , Phongsatha Thanawan
Published: September 2023

Background and Aim: Applying emerging technologies to explore new learning ecology has become the focus of current education reform. Foreign language majors in China were once criticized for their lack of critical thinking abilities. This paper aims to construct a technology-rich classroom learning environment and explore its impact on participants’ English learning and higher-order thinking.
Materials and Methods: This research is a quasi-experimental research design using a quantitative research approach. English language teaching experiment was conducted on 60 samples selected by using the purposive sampling method. Participants were university second-year business English majors, and their English listening, speaking and higher-order thinking skills were pre- and post-tested. Data were collected through tests and quantitative questionnaires. Descriptive statistics and paired-sample T-tests on the hypothesis were conducted by using the statistical software Jamovi.
Results: Participants showed a high evaluation of the constructed technology-rich classroom learning environment. Their English listening skills and speaking competency have been efficiently improved, especially listening comprehension, speaking content, and language use. Their higher-order thinking was also improved, especially their analytical ability and cognitive maturity. Meanwhile, participants demonstrated a high level of cognitive engagement and learning satisfaction.
Conclusion: This study proposed a model for technology-rich learning environment design, as well as a constructivist instructional design model, revealing the mechanism of technology promoting learning and providing relevant methods. The study also demonstrated that the simultaneous development of foreign language learning and higher-order thinking could be achieved in a technology-rich environment. This paper also puts forward suggestions for further enriching instructional design and technology-rich learning environment design.
Preparing for Tomorrow's Challenges: Integrating Future Thinking into Crisis Management in Thai Higher Education
Authors: Thanitbenjasith Phithagorn , Kamkankaew Pongsiri
Published: September 2023

Background and Aim: Thailand's higher education institutions have several problems arising from demographic shifts, digital disruptions, geopolitical transformations, and environmental vulnerabilities. These circumstances call for the implementation of strategic foresight and flexible crisis management strategies, particularly in light of the ongoing COVID-19 pandemic. The objective of this review article is to provide a comprehensive understanding of the importance of maintaining continuity in future thinking as a proactive strategy for crisis management in the context of higher education in Thailand.
Materials and Methods: The current paper serves as an academic platform that consolidates articles, books, and additional resources sourced from several online libraries. The previously mentioned scholarly essay effectively achieved its objectives by employing the methods of analysis and synthesis. The organization of the content in this academic work has been meticulously arranged to present an appropriate level of detail and depth to the research objectives outlined.
Results: This academic article found that the application of forward-looking strategies in the management of crises within the Thai higher education system has the potential to bolster both resilience and sustainability. The essential components encompass proactive strategic planning, comprehensive scenario analysis, the integration of technical breakthroughs, and fostering collaborative efforts. This method guarantees the expansion and achievement of the sector within the dynamic higher education environment.
Conclusion: Forward-looking strategies in Thai higher education management can enhance resilience and sustainability, involving proactive planning, scenario analysis, technical breakthrough integration, and collaborative efforts. To establish themselves as proactive agents of change, Thai higher education institutions must undergo a paradigm shift in their approach to crisis management. This necessitates dedication, cooperation, and embracing the inherent unpredictability. The benefits encompass a robust and future-oriented educational ecosystem that flourishes through challenges, influencing the trajectory of the industry.
Effect of machine learning prediction on surgical decision making for shoulder arthroplasty: a multi-surgeon study
Authors: Shukla Dave R. , Rebolledo Brian J. , Aleem Alexander W. , Jacquot Adrien , Werthel Jean-David , Villacis Diego , Urvoy Manuel
Published: September 2023

Background

Machine learning algorithms for surgical decision making in shoulder arthroplasty has not been reported. Though there are recommendations based on available literature regarding the selection of anatomic versus reverse shoulder replacement, there are no clear guidelines on how this decision should be made. Our aim was to assess the viability of machine learning for this application by evaluating the agreement of the algorithm’s recommendation on type of arthroplasty versus that recommended by six shoulder surgeons.

Methods

There were 84 cases of patients with glenohumeral osteoarthritis planned using a three-dimensional CT-based software. Half of the cases were planned without any ML algorithm-based recommendation available, and half were planned with the recommendation available, and kappa coefficients were calculated to determine agreement.

Results

In 78% of cases, the software’s surgical recommendation on arthroplasty type completely aligned with that of the surgeons. The Cohen’s kappa coefficients for surgeons’ versus software’s recommendations were 0.56 and 0.61 for rounds 1 and 2, respectively, while the Fleiss kappa coefficients (inter-surgeon agreement) were 0.87 and 0.77.

Discussion

Machine learning for the application of guiding surgeons on which type of shoulder arthroplasty to select has demonstrated viability in this study, with further research needed to refine this system.
Effect of ascorbic acid on cellular respiration with mitochondrial reductase in gingival fibroblast
Authors:   Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India, Kumar Raghunandha
Published: September 2023

Vitamin C or L-ascorbic acid has diverse functions in the body, especially healing promotion in tissue injury via participating in the hydroxylation reactions required for collagen formation. Systemic administration of vitamin C plays an important role on gingival fibroblast proliferation and functions. Whether local or rinsing administration of vitamin C alters gingival fibroblast wound healing behavior remains unclear. Therefore, it is of interest to investigate the effect of vitamin C on gingival fibroblast behavior utilizing cell culture. Primary human gingival fibroblasts isolated from gingival tissue were rinsed with medium containing various concentrations of vitamin C. Cell migration, cell viability was assessed using MTT assay. The viability assay showed >95% live cells, and no significant (P > 0.05) difference in these values was observed at different concentrations at 24 hrs. The levels of cell proliferation were not significantly different among the control and experimental groups in 24 hrs experimental time-points (p > 0.05). Vitamin C is nontoxic and can be used for further experiments to validate for clinical application. This was further confirmed with morphological examination after 24hrs incubation on control and experimental group drugs observed under the phase contrast microscope.
Molecular docking analysis of MCL-1 inhibitors for breast cancer management
Authors:   Molecular Genomics and Precision Medicine Department, ExpressMed Diagnostics and Research, Block, 359, Zinj, Kingdom of Bahrain, Alam Qamre
Published: September 2023

Myeloid leukemia 1 (MCL-1), a BCL-2 protein family member, acts as an anti-apoptotic protein by interacting with pro-apoptotic BCL-2 proteins. Its overexpression is frequently observed in numerous cancer types including breast cancer, and is closely linked to the initiation and progression of tumors as well as poor prognosis and resistance to therapeutic interventions. Here, a database of 3402 chemicals with established therapeutic activity against various diseases was chosen and systematically screened against the MCL-1 protein. Visual inspection and binding energy analysis revealed that the compounds OSU-03012, Raltitrexed, Ostarine (MK-2866), Dovitinib (TKI-258), and Varespladib (LY315920) had strong binding affinity for the MCL-1 protein. Notably, their binding affinity was higher than that of the control compounds. These compounds exhibited strong interactions with critical amino acid residues of the MCL-1 protein. Furthermore, these compounds shared several common amino acid residue interactions with the control compounds. These findings suggest that these compounds may be useful as MCL-1 inhibitors in the treatment of breast cancer. However, additional experimental validation is required to confirm these findings.
Molecular docking analysis of natural compounds as TNF-α inhibitors for Crohn’s disease management
Authors:   Medical Technology Department, Faculty of Applied Medical Sciences, University of Tabuk, Saudi Arabia, Moawadh Mamdoh S.
Published: September 2023

Crohn's disease (CD) is a type of inflammatory bowel disease that is immune-mediated and affects the gastrointestinal tract. The chronic and severe nature of this condition leads to diminished health-related life quality, and frequent hospitalization. While medications such as sulfasalazine, corticosteroids, and immuno-suppressants are used to manage the condition, there are no definite treatments for pain and inflammation associated with CD. TNF-α is a prominent target, and medicines such as infliximab and adalimumab have pharmacological efficacy; however, they also have significant toxicity. Here, the natural compound library (2706 compounds) was screened against TNF-α to find natural TNF-α inhibitors to combat CD. The compounds namely ZINC5223934, ZINC6482465, ZINC4098633, ZINC1702729, and ZINC4649679 had higher binding affinity and interaction with the TNF-α protein than the positive control. Furthermore, these compounds had promising drug-like properties, indicating their potential for future exploration and optimization as TNF-α inhibitors for the treatment of CD.
Pre and post-operative self-care management among women undergoing hysterectomy
Authors:   Graphic Era College of Nursing, Graphic Era Deemed to be University, Dehradun, Uttrakhand -248002, India, Gottlieb Amita Shilpa
Published: September 2023

Surgery is a major part in the field of Gynecology. Hysterectomy is the removal of the uterus which is leading non-obstetric surgery worldwide, after caesarean sections. The objective of the current study was to determine how well women undergoing hysterectomy surgery managed their pre-operative and post-operative self-care. A quasi experimental single group pre-test and posttest design was used for this inquiry. Pre - and post-operative self-care management questionnaires were used to collect data from 60 women. Utilizing descriptive and inferential statistics like mean, standard deviation, and chi-square test, data were gathered and examined. Data analysis revealed, the mean post-test knowledge score (23.81) was greater than the mean pre-test knowledge score (10.33). The average disparity was (13.48) with the estimated "t" value (16.003), which was more than the table value (1.67) at 0.05 level of significance, showing that the self-care management education program was successful in increasing women's understanding on hysterectomy. The study concluded that pre- and post-operative self-care management education program had significantly improved health status among women underwent hysterectomy.