bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy
Authors: Li Yana , Jiang Qiu , Ding Zhiwen , Liu Guijian , Yu Peng , Jiang Guoliang , Yu Ziqing , Yang Chunjie , Qian Juying , Jiang Hong , Zou Yunzeng
Published: January 2018

The molecular mechanisms underlying the development of ischemic cardiomyopathy (ICM) remain poorly understood. Gene expression profiling is helpful to discover the molecular changes taking place in ICM. The aim of this study was to identify the genes that are significantly changed during the development of heart failure caused by ICM. The differentially expressed genes (DEGs) were identified from 162 control samples and 227 ICM patients. PANTHER was used to perform gene ontology (GO), and Reactome for pathway enrichment analysis. A protein–protein interaction network was established using STRING and Cytoscape. A further validation was performed by real-time polymerase chain reaction (RT-PCR). A total of 255 common DEGs was found. Gene ontology, pathway enrichment, and protein–protein interaction analysis showed that nucleic acid-binding proteins, enzymes, and transcription factors accounted for a great part of the DEGs, while immune system signaling and cytokine signaling displayed the most significant changes. Furthermore, seven hub genes and nine transcription factors were identified. Interestingly, the top five upregulated DEGs were located on chromosome Y, and four of the top five downregulated DEGs were involved in immune and inflammation signaling. Further, the top DEGs were validated by RT-PCR in human samples. Our study explored the possible molecular mechanisms of heart failure caused by ischemic heart disease.
Short-Range Prediction of the Zone of Moving Vehicles in Arterial Networks
Authors: Forouzandeh Jonaghani Rouzbeh , Honarparvar Sepehr , Khademi Navid
Published: January 2018

In many moving object databases, future locations of vehicles in arterial networks are predicted. While most of studies apply the frequent behavior of historical trajectories or vehicles’ recent kinematics as the basis of predictions, consideration of the dynamics of the intersections is mostly neglected. Signalized intersections make vehicles experience different delays, which vary from zero to some minutes based on the traffic state at intersections. In the absence of traffic signal information (red and green times of traffic signal phases, the queue lengths, approaching traffic volume, turning volumes to each intersection leg, etc.), the experienced delays in traffic signals are random variables. In this paper, we model the probability distribution function (PDF) and cumulative distribution function (CDF) of the delay for any point in the arterial networks based on a spatiotemporal model of the queue at the intersection. The probability of the presence of a vehicle in a zone is determined based on the modeled probability function of the delay. A comparison between the results of the proposed method and a well-known kinematic-based method indicates a significant improvement in the precisions of the predictions.
Thermodynamic Alloy Design of High Strength and Toughness in 300 mm Thick Pressure Vessel Wall of 1.25Cr-0.5Mo Steel
Authors: Na Hye-sung , Kim Byung-hoon , Lee Sang-hoon , Kang Chung-yun
Published: January 2018

In the 21st century, there is an increasing need for high-capacity, high-efficiency, and environmentally friendly power generation systems. The environmentally friendly integrated gasification combined-cycle (IGCC) technology has received particular attention. IGCC pressure vessels require a high-temperature strength and creep strength exceeding those of existing pressure vessels because the operating temperature of the reactor is increased for improved capacity and efficiency. Therefore, high-pressure vessels with thicker walls than those in existing pressure vessels (≤200 mm) must be designed. The primary focus of this research is the development of an IGCC pressure vessel with a fully bainitic structure in the middle portion of the 300 mm thick Cr-Mo steel walls. For this purpose, the effects of the alloy content and cooling rates on the ferrite precipitation and phase transformation behaviors were investigated using JMatPro modeling and thermodynamic calculation; the results were then optimized. Candidate alloys from the simulated results were tested experimentally.
Dating Ore Deposit Using Garnet U–Pb Geochronology: Example from the Xinqiao Cu–S–Fe–Au Deposit, Eastern China
Authors: Zhang Yu , Shao Yongjun , Zhang Rongqing , Li Dengfeng , Liu Zhongfa , Chen Huayong
Published: January 2018

The large Xinqiao Cu–S–Fe–Au deposit in the Tongling ore district, Eastern China, is characterized by a large-scale stratiform orebody, in which garnet is widely distributed as the main gangue mineral associated with mineralization. Xinqiao garnet can be divided into early (Grt1) and late (Grt2) generations based on extensive back-scattered electron (BSE) imaging observations. Laser ablation (LA)-ICP-MS trace element and U–Pb isotope composition analyses indicate that uranium occurs homogeneously within the Xinqiao garnet, and Grt1 and Grt2 have weighted average 207Pb-corrected 206Pb/238U ages of 137.0 ± 7.8 Ma (Mean standard weighted deviation (MSWD) = 4.9) and 129.6 ± 7.1 Ma (MSWD = 1.6), respectively, similar to the zircon U–Pb age (139.6 ± 1.5 Ma) of the Jitou intrusion. These garnet U–Pb ages, combined with the low MnO content and various Y/Ho ratios, suggest that the Xinqiao garnet is likely to have a magmatic hydrothermal replacement origin associated with the Jitou stock. Based on previous studies of the Xinqiao deposit, we infer that the Xinqiao stratiform orebody may have formed from the Early Cretaceous magmatic hydrothermal fluids associated with the Jitou stock, and may have been generated by the Early Cretaceous tectono-thermal event in Eastern China.
Tamm–Horsfall Protein is a Potent Immunomodulatory Molecule and a Disease Biomarker in the Urinary System
Authors: Wu Tsai-Hung , Li Ko-Jen , Yu Chia-Li , Tsai Chang-Youh
Published: January 2018

Tamm–Horsfall protein (THP), or uromodulin (UMOD), is an 80–90-kDa phosphatidylinositol-anchored glycoprotein produced exclusively by the renal tubular cells in the thick ascending limb of the loop of Henle. Physiologically, THP is implicated in renal countercurrent gradient formation, sodium homeostasis, blood pressure regulation, and a defense molecule against infections in the urinary system. Investigations have also revealed that THP is an effective binding ligand for serum albumin, immunoglobulin G light chains, complement components C1 and C1q, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and interferon-γ through its carbohydrate side chains for maintaining circulatory and renal immune homeostasis. Thus, THP can be regarded as part of the innate immune system. UMOD mutations play crucial roles in congenital urolithiasis, hereditary hyperuricemia/gout, and medullary cystic kidney diseases. Recent investigations have focused on the immunomodulatory effects of THP on immune cells and on THP as a disease biomarker of acute and chronic kidney diseases. Our studies have suggested that normal urinary THP, through its epidermal growth factor (EGF)-like domains, binds to the surface-expressed EGF-like receptors, cathepsin G, or lactoferrin to enhance polymorphonuclear leukocyte phagocytosis, proinflammatory cytokine production by monocytes/macrophages, and lymphocyte proliferation by activating the Rho family and mitogen-activated protein kinase signaling pathways. Furthermore, our data support both an intact protein core structure and carbohydrate side chains are important for the different protein-binding capacities of THP. Prospectively, parts of the whole THP molecule may be used for anti-TNF-α therapy in inflammatory diseases, autoantibody-depleting therapy in autoimmune disorders, and immune intensification in immunocompromised hosts.
Molecular Characterization and Expression Profiles of Sp-uchl3 and Sp-uchl5 during Gonad Development of Scylla paramamosain
Authors: Han Kunhuang , Dai Yanbin , Zhang Ziping , Zou Zhihua , Wang Yilei
Published: January 2018

Ubiquitin C-terminal hydrolases (UCHLs) are a subset of deubiquitinating enzymes, and are involved in numerous physiological processes. However, the role of UCHLs during gonad development has not been studied in crustaceans. In this study, we have first cloned and analyzed expression profiling of Sp-uchl3 and Sp-uchl5 genes from mud crab Scylla paramamosain. The full-length cDNA of Sp-uchl3 is of 1804 bp. Its expression level in the ovary was significantly higher than in other tissues (p < 0.01), and during gonadal development, its expression in both O1 and O5 stages was significantly higher than in the other three stages of ovaries (p < 0.05), while in T3 it was higher than in the former two stages of testes (p < 0.05). Meanwhile, the full-length cDNA of Sp-UCHL5 is 1217 bp. The expression level in the ovary was significantly higher than in other tissues (p < 0.01). Its expression in ovaries was higher than in testes during gonadal development (p < 0.05). The expression level in the O5 stage was the highest, followed by the O3 stage in ovarian development, and with no significant difference in the testis development (p > 0.05). These results provide basic data showing the role of Sp-UCHL3 and Sp-UCHL5 in the gonad development of the crab.
Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia Solanacearum
Authors: Song Shihao , Fu Shuna , Sun Xiuyun , Li Peng , Wu Ji’en , Dong Tingyan , He Fei , Deng Yinyue
Published: January 2018

Ralstonia solanacearum is a causative agent of bacterial wilt in many important crops throughout the world. How to control bacterial wilt caused by R. solanacearum is a major problem in agriculture. In this study, we aim to isolate the biocontrol agents that have high efficacy in the control of bacterial wilt. Three new bacterial strains with high antimicrobial activity against R. solanacearum GMI1000 were isolated and identified. Our results demonstrated that these bacteria could remarkably inhibit the disease index of host plant infected by R. solanacearum. It was indicated that strain GZ-34 (CCTCC No. M 2016353) showed an excellent protective effect to tomato under greenhouse conditions. Strain GZ-34 was characterized as Escherichia coli based on morphology, biochemistry, and 16S rRNA analysis. We identified that the main antimicrobial compounds produced by E. coli GZ-34 were cyclo(l-Pro-d-Ile) and cyclo(l-Pro-l-Phe) using electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) analysis. The two active compounds also interfered with the expression levels of some pathogenicity-contributors of R. solanacearum. Furthermore, cyclo(l-Pro-l-Phe) effectively inhibited spore formation of Magnaporthe grisea, which is a vital pathogenesis process of the fungal pathogen, suggesting cyclic dipeptides from E. coli are promising potential antimicrobial agents with broad-spectrum activity to kill pathogens or interfere with their pathogenesis.
From Extraction of Local Structures of Protein Energy Landscapes to Improved Decoy Selection in Template-Free Protein Structure Prediction
Authors: Akhter Nasrin , Shehu Amarda
Published: January 2018

Due to the essential role that the three-dimensional conformation of a protein plays in regulating interactions with molecular partners, wet and dry laboratories seek biologically-active conformations of a protein to decode its function. Computational approaches are gaining prominence due to the labor and cost demands of wet laboratory investigations. Template-free methods can now compute thousands of conformations known as decoys, but selecting native conformations from the generated decoys remains challenging. Repeatedly, research has shown that the protein energy functions whose minima are sought in the generation of decoys are unreliable indicators of nativeness. The prevalent approach ignores energy altogether and clusters decoys by conformational similarity. Complementary recent efforts design protein-specific scoring functions or train machine learning models on labeled decoys. In this paper, we show that an informative consideration of energy can be carried out under the energy landscape view. Specifically, we leverage local structures known as basins in the energy landscape probed by a template-free method. We propose and compare various strategies of basin-based decoy selection that we demonstrate are superior to clustering-based strategies. The presented results point to further directions of research for improving decoy selection, including the ability to properly consider the multiplicity of native conformations of proteins.
5-Bromo-4′,5′-bis(dimethylamino)fluorescein: Synthesis and Photophysical Studies
Authors: Hwang Jun , Lee Jung-Yean , Cho Chang-Woo , Choi Wonjun , Lee Yejin , Shim Sangdeok , Hwang Gil
Published: January 2018

In this study, three new fluorescein derivatives—5-bromo-4′,5′-dinitrofluorescein (BDNF), 5-bromo-4′,5′-diaminofluorescein (BDAF), and 5-bromo-4′,5′-bis(dimethylamino)fluorescein (BBDMAF)—were synthesized and their pH-dependent protolytic equilibria were investigated. In particular, BBDMAF exhibited pH-dependent fluorescence, showing strong emission only at pH 3–6. BBDMAF bears a bromine moiety and thus, can be used in various cross-coupling reactions to prepare derivatives and take advantage of its unique emission properties. To confirm this, the Suzuki and Sonogashira reactions of BBDMAF with phenylboronic acid and phenylacetylene, respectively, were performed, and the desired products were successfully obtained.
Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists
Authors: Karoutzou Olga , Kwak Seung-Hwa , Lee So-Deok , Martínez-Falguera Daina , Sureda Francesc , Vázquez Santiago , Kim Yong-Chul , Barniol-Xicota Marta
Published: January 2018

Multi-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer’s Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein—which is open to further optimization—represents the first member of a new class of MTDLs.
Pseudotype Neutralization Assays: From Laboratory Bench to Data Analysis
Authors: Ferrara Francesca , Temperton Nigel
Published: January 2018

Pseudotype neutralization assays are powerful tools to study functional antibody responses against viruses in low biosafety laboratories. However, protocols described in the literature differ widely with respect to material, reagents, and methods used to perform these assays and to analyse the raw data generated. This could result in discrepancies between the results of different laboratories even when the same pseudotypes and the same samples are analysed. Here, we describe, in detail, an experimental protocol to perform pseudotype neutralization assays using lentiviral pseudotypes bearing influenza haemagglutinin and expressing firefly luciferase. We also present the steps necessary to analyse the data and calculate the half maximal inhibitory concentration of the sera analysed. This protocol will provide support for the validation and the standardization of the pseudotype neutralization assay for influenza virus serology. Additionally, it will provide a starting point for the development of pseudotype neutralization assays using pseudotypes bearing other viral envelope proteins.
Investigating Binge Eating Using Ecological Momentary Assessment: The Importance of an Appropriate Sampling Frequency
Authors: Kockler Tobias , Santangelo Philip , Ebner-Priemer Ulrich
Published: January 2018

With great interest, we read the recently published review on emotion regulation in binge eating disorder (BED) by Dingemans et al. [1].[...]
Photoluminescence Enhancement of Poly(3-methylthiophene) Nanowires upon Length Variable DNA Hybridization
Authors: Huang Jingyuan , Choi Jinho , Lee Gil , Chen Fengchun , Cui Chunzhi , Jin Long , Park Dong
Published: January 2018

The use of low-dimensional inorganic or organic nanomaterials has advantages for DNA and protein recognition due to their sensitivity, accuracy, and physical size matching. In this research, poly(3-methylthiophene) (P3MT) nanowires (NWs) are electrochemically prepared with dopant followed by functionalization with probe DNA (pDNA) sequence through electrostatic interaction. Various lengths of pDNA sequences (10-, 20- and 30-mer) are conjugated to the P3MT NWs respectively followed with hybridization with their complementary target DNA (tDNA) sequences. The nanoscale photoluminescence (PL) properties of the P3MT NWs are studied throughout the whole process at solid state. In addition, the correlation between the PL enhancement and the double helix DNA with various lengths is demonstrated.
Social Acceptance for Reclaimed Water Use: A Case Study in Bengaluru
Authors: Ravishankar Chaya , Nautiyal Sunil , Seshaiah Manasi
Published: January 2018

The main source of water to the peri-urban areas of Bengaluru is groundwater. Access to groundwater is through tankers, private borewells, Bruhat Bengaluru MahanagaraPalike (Urban Local Body) borewells, and public stand posts. All modes other than tankers provide water to the community free of charge. Reclaimed water from sewage treatment plants (STPs) is in use by industries and some gated communities and multistoried apartments for toilet flushing and landscaping. For individual households in peri-urban areas of Bengaluru, it could be an additional water source replacing expensive water supply through tankers; reducing demand for groundwater (a finite resource); improving the sanitation system by providing drainage systems and preventing groundwater contamination from black and grey water. Consequently, this research paper investigates the willingness of residents in peri-urban areas of Bengaluru to use reclaimed water for non-potable end uses. To investigate residents’ willingness and key motivations for the use of reclaimed water, a survey of residents in the peri-urban ward of Bellandur was conducted. In this region, the sewerage board had prepared a media advertisement to create awareness of—and to sell—reclaimed water to other users, including local residents. This advertisement was shown to respondents, asking if they were willing to accept and buy the reclaimed water at 15 Indian Rupees (INR) per kiloliter. Sixty-seven percent of residents who were household owners were willing to buy reclaimed water, 20% were concerned about hygiene, and 33% of respondents lacked trust in the public agency with respect to water quality standards. The study concludes that public awareness from key stakeholders is essential for the reuse of reclaimed water. It also recommends stringent regulation by levying fees for groundwater extraction in addition to making reclaimed water readily available and supplied free of charge to the consumers. In addition, the quality of reclaimed water should meet international standards to gain the confidence of the people.
Christian Ethical Boundaries of Suicide Prevention
Authors: Liégeois Axel , De Schrijver Stefaan
Published: January 2018

In Western countries the general rule is that caregivers do everything possible to prevent suicide. The aim of this essay is to critically reflect on that position along three questions: is there an unconditional obligation to live, how far does the duty reach to safeguard life, and how does one deal with the tension between suicide prevention and euthanasia? The study material consists of Christian theological and ethical literature and relevant legislation, while the method is a religious ethical reflection, clarified by means of a case study. We consider suicide as an expression of an existential search for meaning and interwoven with psychiatric problems. After discussing the three ethical arguments against suicide, we conclude that the inviolability of life is a generally recognized and fundamental value, but that there is no unconditional obligation to live. Nevertheless, there is a legal duty to safeguard life. In practice however, restriction of freedom and coercion are counterproductive in the search for meaning and require a proportional assessment between inviolability of life and autonomy. Finally, the legal possibility of euthanasia in mental suffering or medically assisted suicide brings caregivers in a confusing situation. Good companionship of the euthanasia request may help finding a new life perspective and hence may contribute to suicide prevention.
Psychiatry, a Secular Discipline in a Postsecular World? A Review
Authors: Damberg Nissen Ricko , Gildberg Frederik , Hvidt Niels
Published: January 2018

Postsecular theory is developing in academic circles, including the psychiatric field. By asking what the postsecular perspective might imply for the secular discipline of psychiatry, the aim of this study was to examine the postsecular perspective in relation to the secular nature of psychiatry, by way of a narrative review. In a systematic search for literature, relevant articles were identified and analyzed thematically. Thirteen articles were included, and three intertextual themes were identified, which represented ongoing international dialogues in relation to psychiatry and religion—such as intervention, integration, identity, the religious or irreligious psychiatrist, and the multicultural setting of the discipline. Furthermore, the postsecular perspective reveals a (potential) bias against the religious worldviews inherent in the secular. Postsecular theory can contribute to the ongoing discussions of how psychiatry, as a secular discipline, approaches the religious in the lives of patients and psychiatrists.
Impacts on the Urban Environment: Land Cover Change Trajectories and Landscape Fragmentation in Post-War Western Area, Sierra Leone
Authors: Gbanie Solomon , Griffin Amy , Thornton Alec
Published: January 2018

An influential underlying driver of human-induced landscape change is civil war and other forms of conflict that cause human displacement. Internally displaced persons (IDPs) increase environmental pressures at their destination locations while reducing them at their origins. This increased pressure presents an environment for increased land cover change (LCC) rates and landscape fragmentation. To test whether this hypothesis is correct, this research sought to understand LCC dynamics in the Western Area of Sierra Leone from 1976 to 2011, a period including pre-conflict, conflict, and post-conflict eras, using Landsat and SPOT satellite imagery. A trajectory analysis of classified images compared LCC trajectories before and during the war (1976–2000) with after the war (2003–2011). Over the 35-year period, the built-up land class rapidly increased, in parallel with an increase in urban and peri-urban agriculture. During the war, urban and peri-urban agriculture became a major livelihood activity for displaced rural residents to make the region food self-sufficient, especially when the war destabilised food production activities. The reluctance of IDPs to return to their rural homes after the war caused an increased demand for land driven by housing needs. Meanwhile, protected forest and other forest declined. A significant finding to emerge from this research is that landscape fragmentation increased in conjunction with declining forest cover while built-up areas aggregated. This has important implications for the region’s flora, fauna, and human populations given that other research has shown that landscape fragmentation affects the landscape’s ability to provide important ecosystem services.
Aerosol Optical Depth Retrieval over East Asia Using Himawari-8/AHI Data
Authors: Zhang Wenhao , Xu Hui , Zheng Fengjie
Published: January 2018

This paper presents a new algorithm to retrieve the aerosol optical depth (AOD) from a Himawari-8 Advanced Himawari Imager (AHI). Six typical aerosol models that derived from the long-term ground-based observations of East Asia are used in AOD retrieval. To accurately determine the surface reflectance, improved channel relationships between red, blue, and shortwave infrared (SWIR) are built up according to the infrared Normalized Difference Vegetation Index (NDVISWIR). Based on the new derived aerosol models and improved channel relationships, AOD over East Asian is retrieved by using the AHI data. The results are compared with Moderate Resolution Imaging Spectroradiometer (MODIS) aerosol products (MOD04 and MYD04) and yielded a correlation coefficient lager than 0.8 (R = 0.87 and 0.92, respectively). In addition, the retrieved AOD values are also validated by ground-based measurements at 12 Aerosol Robotic Network (AERONET) locations and revealed a good agreement between them (R = 0.86).
Dependence of C-Band Backscatter on Ground Temperature, Air Temperature and Snow Depth in Arctic Permafrost Regions
Authors: Bergstedt Helena , Zwieback Simon , Bartsch Annett , Leibman Marina
Published: January 2018

Microwave remote sensing has found numerous applications in areas affected by permafrost and seasonally frozen ground. In this study, we focused on data obtained by the Advanced Scatterometer (ASCAT, C-band) during winter periods when the ground is assumed to be frozen. This paper discusses the relationships of ASCAT backscatter with snow depth, air and ground temperature through correlations and the analysis of covariance (ANCOVA) to quantify influences on backscatter values during situations of frozen ground. We studied sites in Alaska, Northern Canada, Scandinavia and Siberia. Air temperature and snow depth data were obtained from 19 World Meteorological Organization (WMO) and 4 Snow Telemetry (SNOTEL) stations. Ground temperature data were obtained from 36 boreholes through the Global Terrestrial Network for Permafrost Database (GTN-P) and additional records from central Yamal. Results suggest distinct differences between sites with and without underlying continuous permafrost. Sites characterized by high freezing indices (>4000 degree-days) have consistently stronger median correlations of ASCAT backscatter with ground temperature for all measurement depths. We show that the dynamics in winter-time backscatter cannot be solely explained through snow processes, but are also highly correlated with ground temperature up to a considerable depth (60 cm). These findings have important implications for both freeze/thaw and snow water equivalent retrieval algorithms based on C-band radar measurements.
On Statistical Approaches to Generate Level 3 Products from Satellite Remote Sensing Retrievals
Authors: Zammit-Mangion Andrew , Cressie Noel , Shumack Clint
Published: January 2018

Satellite remote sensing of trace gases such as carbon dioxide (CO2) has increased our ability to observe and understand Earth’s climate. However, these remote sensing data, specifically Level 2 retrievals, tend to be irregular in space and time, and hence, spatio-temporal prediction is required to infer values at any location and time point. Such inferences are not only required to answer important questions about our climate, but they are also needed for validating the satellite instrument, since Level 2 retrievals are generally not co-located with ground-based remote sensing instruments. Here, we discuss statistical approaches to construct Level 3 products from Level 2 retrievals, placing particular emphasis on the strengths and potential pitfalls when using statistical prediction in this context. Following this discussion, we use a spatio-temporal statistical modelling framework known as fixed rank kriging (FRK) to obtain global predictions and prediction standard errors of column-averaged carbon dioxide based on Version 7r and Version 8r retrievals from the Orbiting Carbon Observatory-2 (OCO-2) satellite. The FRK predictions allow us to validate statistically the Level 2 retrievals globally even though the data are at locations and at time points that do not coincide with validation data. Importantly, the validation takes into account the prediction uncertainty, which is dependent both on the temporally-varying density of observations around the ground-based measurement sites and on the spatio-temporal high-frequency components of the trace gas field that are not explicitly modelled. Here, for validation of remotely-sensed CO2 data, we use observations from the Total Carbon Column Observing Network. We demonstrate that the resulting FRK product based on Version 8r compares better with TCCON data than that based on Version 7r, in terms of both prediction accuracy and uncertainty quantification.
A Real-Time Ultraviolet Radiation Imaging System Using an Organic Photoconductive Image Sensor
Authors: Okino Toru , Yamahira Seiji , Yamada Shota , Hirose Yutaka , Odagawa Akihiro , Kato Yoshihisa , Tanaka Tsuyoshi
Published: January 2018

We have developed a real time ultraviolet (UV) imaging system that can visualize both invisible UV light and a visible (VIS) background scene in an outdoor environment. As a UV/VIS image sensor, an organic photoconductive film (OPF) imager is employed. The OPF has an intrinsically higher sensitivity in the UV wavelength region than those of conventional consumer Complementary Metal Oxide Semiconductor (CMOS) image sensors (CIS) or Charge Coupled Devices (CCD). As particular examples, imaging of hydrogen flame and of corona discharge is demonstrated. UV images overlapped on background scenes are simply made by on-board background subtraction. The system is capable of imaging weaker UV signals by four orders of magnitude than that of VIS background. It is applicable not only to future hydrogen supply stations but also to other UV/VIS monitor systems requiring UV sensitivity under strong visible radiation environment such as power supply substations.
The Effect of Absorptive Capacity on Green Customer Capital under an Organizational Unlearning Context
Authors: Martelo-Landroguez Silvia , Albort-Morant Gema , Leal-Rodríguez Antonio , Ribeiro-Soriano Belén
Published: January 2018

Environmental management is becoming increasingly important within organizations and forms an essential part of their strategies. As customers are more concerned with the care of the environment, companies are required to be more aware of their actions. Consequently, companies must ignore their historical mindsets and assumptions to be able to adopt green-oriented practices and processes. Our specific research questions are: (i) How can firms become (more) green-oriented? and (ii) how can knowledge-based organizational capabilities drive this shift into greener companies, which may enhance green customer capital? The research model describes how the complementary roles of absorptive capacity (direct effect) and the fostering of an organizational unlearning context (moderating effect) affects green customer capital within the Spanish automotive component manufacturing sector. Empirical results reveal that to create green customer capital, companies should absorb new knowledge and build a context of organizational unlearning. In today’s competitive environment, knowledge rapidly becomes obsolete, so companies need to encourage unlearning to make space for new knowledge that meets environmental needs and keeps pace with changing customer preferences. The research hypotheses were tested using partial least squares (PLS) path-modeling.
Zone-Aware Service Platform: A New Concept of Context-Aware Networking and Communications for Smart-Home Sustainability
Authors: Byun Jinsung , Park Sanguk , Cho Keonhee , Park Sehyun
Published: January 2018

Recent advances in networking and communications removed the restrictions of time and space in information services. Context-aware service systems can support the predefined services in accordance with user requests regardless of time and space. However, due to their architectural limitations, the recent systems are not so flexible to provide device-independent services by multiple service providers. Recently, researchers have focused on a new service paradigm characterized by high mobility, service continuity, and green characteristics. In line with these efforts, improved context-aware service platforms have been suggested to make the platform possible to manage the contexts to provide the adaptive services for multi-user and locations. However, this platform can only support limited continuity and mobility. In other words, the existing system cannot support seamless service provision among different service providers with respect to the changes of mobility, situation, device, and network. Furthermore, the existing context-aware service platform is significant reliance on always-on infrastructure, which leads to great amounts of energy consumption inevitably. Therefore, we subsequently propose a new concept of context-aware networking and communications, namely a zone-aware service platform. The proposed platform autonomously reconfigures the infrastructure and maintains a service session interacting with the middleware to support cost- and energy-efficient pervasive services for smart-home sustainability.
Supply Chain Management and Business Sustainability Synergy: A Theoretical and Integrated Perspective
Authors: Rezaee Zabihollah
Published: January 2018

Global business organizations face the challenges of adapting proper sustainability strategies and practices to effectively respond to social, ethical, environmental, and governance issues while improving financial performance in creating value for their shareholders. Business sustainability enables the integration of financial economic sustainability performance and non-financial environmental, social, ethical, and governance sustainability performance dimensions into the corporate culture, supply chain management and business models in creating shared value for all stakeholders. Business literature has provided mixed evidence of the tension, and possible link, between financial and non-financial sustainability performance dimensions and sustainability theories have yet to sufficiently address this tension. This paper attempts to fill this void by shedding light on the link between various dimensions of sustainability performance, their integrated effect on creating shared value for all stakeholders and their implications for supply chain sustainability. This paper examines the synergy between business sustainability and supply chain management by presenting a framework consisting of sustainability theories, sustainability performance dimensions, sustainability shared value concept, and sustainability best practices. Companies can use the suggested framework in integrating both financial and non-financial sustainability initiatives into their supply chain sustainability from production design, purchasing and inbound logistics, and manufacturing process to distribution and outbound logistics.
The Sustainable Role of the E-Trust in the B2C E-Commerce of Vietnam
Authors: Choi Yongrok , Mai Do
Published: January 2018

Vietnam, as a new emerging market, especially in e-business, has been promoting its emerging e-commerce market in Southeast Asia using aggressive players such as Lazada. Nonetheless, Vietnam has strong cultural background of risk-averse attitudes, like other developing countries, thereby deferring sustainable transformation into the e-business revolution. Therefore, it is necessary to examine the factors leading to the sustainable performance of e-commerce businesses, because highly risk-avert attitudes still cause many problems due to low levels of trust. In this perspective of trust, this research may contribute to promoting Vietnamese online shopping trends and suggesting ways for sustainable business to achieve success in B2C e-commerce. The purpose of this research is to examine whether or not the characteristics of e-service quality (usefulness, convenience, security, responsiveness, and assurance) have a positive influence on customer loyalty, one of the sustainable success factors in this growing e-commerce industry in Asian markets. Using questionnaires and structural equation modelling, we concluded that it is crucial to promote e-trust as a vital element, because it lacks, in the short-run, an initial e-trust.
Responses of Oat Grains to Fusarium poae and F. langsethiae Infections and Mycotoxin Contaminations
Authors: Martin Charlotte , Schöneberg Torsten , Vogelgsang Susanne , Mendes Ferreira Carla , Morisoli Romina , Bertossa Mario , Bucheli Thomas , Mauch-Mani Brigitte , Mascher Fabio
Published: January 2018

Recent increases of Fusarium head blight (FHB) disease caused by infections with F. poae (FP) and F. langsethiae (FL) have been observed in oats. These pathogens are producers of nivalenol (NIV) and T-2/HT-2 toxin (T-2/HT-2), respectively, which are now considered major issues for cereal food and feed safety. To date, the impact of FP and FL on oat grains has not yet been identified, and little is known about oat resistance elements against these pathogens. In the present study, the impact of FL and FP on oat grains was assessed under different environmental conditions in field experiments with artificial inoculations. The severity of FP and FL infection on grains were compared across three field sites, and the resistance against NIV and T-2/HT2 accumulation was assessed for seven oat genotypes. Grain weight, β-glucan content, and protein content were compared between infected and non-infected grains. Analyses of grain infection showed that FL was able to cause infection on the grain only in the field site with the highest relative humidity, whereas FP infected grains in all field sites. The FP infection of grains resulted in NIV contamination (between 30–500 μg/kg). The concentration of NIV in grains was not conditioned by environmental conditions. FL provoked an average contamination of grains with T-2/HT-2 (between 15–132 μg/kg). None of the genotypes was able to fully avoid toxin accumulation. The general resistance of oat grains against toxin accumulation was weak, and resistance against NIV accumulation was strongly impacted by the interaction between the genotype and the environment. Only the genotype with hull-less grains showed partial resistance to both NIV and T-2/HT-2 contamination. FP and FL infections could change the β-glucan content in grains, depending on the genotypes and environmental conditions. FP and FL did not have a significant impact on the thousand kernel weight (TKW) and protein content. Hence, resistance against toxin accumulation remains the only indicator of FHB resistance in oat. Our results highlight the need for new oat genotypes with enhanced resistance against both NIV and T-2/HT-2 to ensure food and feed safety.
The Rise of Imported Dengue Infections in Victoria, Australia, 2010–2016
Authors: Rowe Stacey L. , Thevarajan Irani , Richards Jack , Gibney Katherine , Simmons Cameron P.
Published: January 2018

Dengue notifications have increased dramatically over the past seven years in Victoria, Australia—a trend which has been seen nationally and reflects increased cases internationally. We reviewed the epidemiology of dengue among Victorian travellers, changes in diagnostic methods and describe the burden placed on local health systems resulting from this disease of public health importance. Cases of dengue notified to the Department of Health and Human Services in Victoria, Australia, between 1 January 2010 and 31 December 2016 were included in this review. Demographic, clinical, diagnostic methods, and risk factor data were examined using descriptive epidemiological analyses. Cases of dengue increased on average by 22% per year, with a total of 2187 cases (5.5 cases/100,000 population) notified over the 7-year reporting period. The most frequently reported country of acquisition was Indonesia (45%) followed by Thailand (14%). The use of multiple diagnostic methods, including the non-structural protein 1 antigen (NS1Ag) detection test, increased over time. The median time between onset of illness and diagnosis diminished from 9 days (IQR: 2–15) in 2010 to 4 days (IQR: 2–7) in 2016. Proportionally more cases were discharged directly from emergency departments in recent years (10% in 2010 to 28% in 2016, p < 0.001).The increasing incidence of dengue in Australia is reflective of its growing prominence as a travel medicine problem in western countries. For travellers with non-severe dengue, the improved timeliness of dengue diagnostics allows for consideration of best practice ambulatory management approaches as used in endemic areas.
The COUNTDOWN Study Protocol for Expansion of Mass Drug Administration Strategies against Schistosomiasis and Soil-Transmitted Helminthiasis in Ghana
Authors: Campbell Suzy , Osei-Atweneboana Mike , Stothard Russell , Koukounari Artemis , Cunningham Lucas , Armoo Samuel , Biritwum Nana-Kwadwo , Gyapong Margaret , MacPherson Eleanor , Theobald Sally , Woode Maame , Khan Jahangir , Niessen Louis , Adams Emily
Published: January 2018

(1) Background: Current international policy for schistosomiasis and soil-transmitted helminthiasis (STH) control emphasises mass administration of deworming drugs in school-based programmes. However, this approach is insufficient to control the transmission of these diseases, and their burden in non-school cohorts is recognised, albeit under-researched. This research will investigate the feasibility and acceptability of expanding access to praziquantel (PZQ) against schistosomiasis, and albendazole (ALB) against STH, to communities in selected transmission settings in Ghana. (2) Methods: A three-site longitudinal study will be implemented to investigate the effectiveness of expanding treatment strategies for PZQ and ALB to community members. In the context of community mass drug administration (to preschool children, school non-attending children, and adults, including pregnant women), the intervention will be assessed in a random sample of community members, at baseline with follow-up at 6, 12, and 18 months. In each community, 658 participants will be enrolled, and 314 followed up at each time point. The primary outcome measure is the prevalence of infection of Schistosoma haematobium and/or S. mansoni at study endpoint, as assessed by longitudinal surveys. Secondary outcomes are to quantify the infection of schistosomiasis and STH infections in non-treated cohorts, reductions in prevalence of STH, and intensity of schistosomiasis and STH, and treatment coverage. Nested within this study will be qualitative, cost-benefit, and cost-effectiveness evaluations that will explore accessibility, feasibility, and economic impact of expanded treatment from different complementary perspectives. (3) Discussion: Using a multidisciplinary approach, this study will generate evidence for improved availability, acceptability, affordability, and accessibility to deworming drugs against schistosomiasis and STH to individuals and communities in Ghana. This is likely to have considerable research, programmatic, and political value to contribute evidence for national programme policy development within Ghana, and, more broadly, World Health Organization policy development.
Distinct Effects of Type I and III Interferons on Enteric Viruses
Authors: Ingle Harshad , Peterson Stefan , Baldridge Megan
Published: January 2018

Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and recent work has identified unique roles for IFN subtypes in regulating different aspects of infection. Currently emerging is a common theme that type III IFNs are critical in localized control of infection at mucosal barrier sites, while type I IFNs are important for broad systemic control of infections. The intestine is a particular site of interest for exploring these effects, as in addition to being the port of entry for a multitude of pathogens, it is a complex tissue with a variety of cell types as well as the presence of the intestinal microbiota. Here we focus on the roles of type I and III IFNs in control of enteric viruses, discussing what is known about signaling downstream from these cytokines, including induction of specific IFN-stimulated genes. We review viral strategies to evade IFN responses, effects of IFNs on the intestine, interactions between IFNs and the microbiota, and briefly discuss the role of IFNs in controlling viral infections at other barrier sites. Enhanced understanding of the coordinate roles of IFNs in control of viral infections may facilitate development of antiviral therapeutic strategies; here we highlight potential avenues for future exploration.
An Ameliorative Whale Optimization Algorithm for Multi-Objective Optimal Allocation of Water Resources in Handan, China
Authors: Yan Zhihong , Sha Jinxia , Liu Bin , Tian Wei , Lu Jipan
Published: January 2018

With the deepening discrepancy between water supply and demand caused by water shortages, alleviating water shortages by optimizing water resource allocation has received extensive attention. How to allocate water resources optimally, rapidly, and effectively has become a challenging problem. Thus, this study employs a meta-heuristic swarm-based algorithm, the whale optimization algorithm (WOA). To overcome drawbacks like relatively low convergence precision and convergence rates, when applying the WOA algorithm to complex optimization problems, logistic mapping is used to initialize swarm location, and inertia weighting is employed to improve the algorithm. The resulting ameliorative whale optimization algorithm (AWOA) shows substantially enhanced convergence rates and precision than the WOA and particle swarm optimization algorithms, demonstrating relatively high reliability and applicability. A water resource allocation optimization model with optimal economic efficiency and least total water shortage volume is established for Handan, China, and solved by the AWOA. The allocation results better reflect actual water usage in Handan. In 2030, the p = 50% total water shortage is forecast as 404.34 × 106 m3 or 14.8%. The shortage is mainly in the primary agricultural sector. The allocation results provide a reference for regional water resources management.
Gemini Surfactant-Modified Activated Carbon for Remediation of Hexavalent Chromium from Water
Authors: Zhou Yingying , Wang Zhenghua , Hursthouse Andrew , Ren Bozhi
Published: January 2018

Gemini surfactants, with double hydrophilic and hydrophobic groups, offer potentially orders of magnitude greater surface activity compared to similar single unit molecules. A cationic Gemini surfactant (Propyl didodecyldimethylammonium Bromide, PDDDAB) and a conventional cationic surfactant (Dodecyltrimethylammonium Bromide, DTAB) were used to pre-treat and generate activated carbon. The removal efficiency of the surfactant-modified activated carbon through adsorption of chromium(VI) was investigated under controlled laboratory conditions. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to investigate the surface changes of surfactant-modified activated carbon. The effect of important parameters such as adsorbent dosage, pH, ionic strength and contact time were also investigated. The chromium(VI) was adsorbed more significantly on the Gemini surfactant-modified activated carbon than on the conventional surfactant-modified activated carbon. The correlation coefficients show the data best fit the Freundlich model, which confirms the monolayer adsorption of chromium(VI) onto Gemini surfactant-modified activated carbon. From this assessment, the surfactant-modified (especially Gemini surfactant-modified) activated carbon in this study showed promise for practical applications to treat water pollution.