bluuebunny/crossref_metadata_2025 huggingface dataset:
Overcoming the Hurdles of Autologous T-Cell-Based Therapies in B-Cell Non-Hodgkin Lymphoma
Authors: van Bruggen Jaco A. C. , Martens Anne W. J. , Tonino Sanne H. , Kater Arnon P.
Published: December 2020

The next frontier towards a cure for B-cell non-Hodgkin lymphomas (B-NHL) is autologous cellular immunotherapy such as immune checkpoint blockade (ICB), bispecific antibodies (BsAbs) and chimeric antigen receptor (CAR) T-cells. While highly successful in various solid malignancies and in aggressive B-cell leukemia, this clinical success is often not matched in B-NHL. T-cell subset skewing, exhaustion, expansion of regulatory T-cell subsets, or other yet to be defined mechanisms may underlie the lack of efficacy of these treatment modalities. In this review, a systematic overview of results from clinical trials is given and is accompanied by reported data on T-cell dysfunction. From these results, we distill the underlying pathways that might be responsible for the observed differences in clinical responses towards autologous T-cell-based cellular immunotherapy modalities between diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL). By integration of the clinical and biological findings, we postulate strategies that might enhance the efficacy of autologous-based cellular immunotherapy for the treatment of B-NHL.
G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181
Authors: Park Shin Young , Kim Ki Yun , Jun Do Youn , Hwang Su-Kyeong , Kim Young Ho
Published: December 2020

In vitro antitumor activity of the CDK7 inhibitor BS-181 against human T-ALL Jurkat cells was determined. Treatment of Jurkat clones (JT/Neo) with BS-181 caused cytotoxicity and several apoptotic events, including TRAIL/DR4/DR5 upregulation, c-FLIP down-regulation, BID cleavage, BAK activation, ΔΨm loss, caspase-8/9/3 activation, and PARP cleavage. However, the BCL-2-overexpressing Jurkat clone (JT/BCL-2) abrogated these apoptotic responses. CDK7 catalyzed the activating phosphorylation of CDK1 (Thr161) and CDK2 (Thr160), and CDK-directed retinoblastoma phosphorylation was attenuated in both BS-181-treated Jurkat clones, whereas only JT/BCL-2 cells exhibited G1 cell cycle arrest. The G1-blocker hydroxyurea augmented BS-181-induced apoptosis by enhancing TRAIL/DR4/DR5 upregulation and c-FLIP down-regulation. BS-181-induced FITC–annexin V-positive apoptotic cells were mostly in the sub-G1 and G1 phases. BS-181-induced cytotoxicity and mitochondrial apoptotic events (BAK activation/ΔΨm loss/caspase-9 activation) in Jurkat clones I2.1 (FADD-deficient) and I9.2 (caspase-8-deficient) were significantly lower than in A3 (wild-type). Exogenously added recombinant TRAIL (rTRAIL) markedly synergized BS-181-induced apoptosis in A3 cells but not in normal peripheral T cells. The cotreatment cytotoxicity was significantly reduced by the DR5-blocking antibody but not by the DR4-blocking antibody. These results demonstrated that the BS-181 anti-leukemic activity is attributed to extrinsic TRAIL/DR5-dependent apoptosis preferentially induced in G1-arrested cells, and that BS-181 and rTRAIL in combination may hold promise for T-ALL treatment.
Mechanisms of Immunosuppression in Colorectal Cancer
Authors: Zhang Yang , Rajput Ashwani , Jin Ning , Wang Jing
Published: December 2020

CRC is the third most diagnosed cancer in the US with the second-highest mortality rate. A multi-modality approach with surgery/chemotherapy is used in patients with early stages of colon cancer. Radiation therapy is added to the armamentarium in patients with locally advanced rectal cancer. While some patients with metastatic CRC are cured, the majority remain incurable and receive palliative chemotherapy as the standard of care. Recently, immune checkpoint blockade has emerged as a promising treatment for many solid tumors, including CRC with microsatellite instability. However, it has not been effective for microsatellite stable CRC. Here, main mechanisms of immunosuppression in CRC will be discussed, aiming to provide some insights for restoring immunosurveillance to improve treatment efficacy in CRC.
Prospective Study of Intensity-Modulated Radiation Therapy for Locally Advanced Breast Cancer
Authors: Bataille Benoît , Raoudha Bennadji , Le Tinier Florence , Basson Laurent , Escande Alexandre , Langin Hélène , Tresch Emmanuelle , Crop Frederik , Darloy Franck , Carlier Damien , Lartigau Eric , Pasquier David
Published: December 2020

The objective of this study was to evaluate the acute and medium-term toxicities, the quality of life, and aesthetic results of patients with breast cancer (BC) treated with tomotherapy. This was a prospective study, including patients with BC treated by tomotherapy. Radiation therapy delivered 50 Gy in 25 fractions to the breast or chest wall and to lymph node areas, with a simultaneous integrated boost at a dose of 60 Gy at the tumor bed in cases of breast conservative surgery. We included 288 patients, 168 and 120 treated with breast-conserving surgery and mastectomy respectively. Two hundred sixty patients (90.3%) received lymph node irradiation. Median follow-up was 25 months (6–48). Acute dermatitis was observed in 278 patients (96.5%), mostly grade 1 (59.7%). The aesthetic aspect of the breast at one year was reported as “good” or “excellent” in 84.6% of patients. The patients’ quality of life improved over time, especially those treated with chemotherapy. The two-year overall survival and disease-free survival were 97.8% (95% confidence interval (CI): 94.1–99.2%), and 93.4% (95% CI: 89.2–96.0%) respectively. Tomotherapy for locally advanced BC has acceptable toxicity, supporting its use in this indication; however, longer follow-up is needed to assess long-term outcomes.
Etiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research
Authors: Deva Anand K. , Turner Suzanne D. , Kadin Marshall E. , Magnusson Mark R. , Prince H. Miles , Miranda Roberto N. , Inghirami Giorgio G. , Adams William P.
Published: December 2020

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a CD30-positive, anaplastic lymphoma kinase-negative T-cell lymphoma. Where implant history is known, all confirmed cases to date have occurred in patients with exposure to textured implants. There is a spectrum of disease presentation, with the most common occurring as a seroma with an indolent course. A less common presentation occurs as locally advanced or, rarely, as metastatic disease. Here we review the immunological characteristics of BIA-ALCL and potential triggers leading to its development. BIA-ALCL occurs in an inflammatory microenvironment with significant lymphocyte and plasma cell infiltration and a prominent Th1/Th17 phenotype in advanced disease. Genetic lesions affecting the JAK/STAT signaling pathway are commonly present. Proposed triggers for the development of malignancy include mechanical friction, silicone implant shell particulates, silicone leachables, and bacteria. Of these, the bacterial hypothesis has received significant attention, supported by a plausible biologic model. In this model, bacteria form an adherent biofilm in the favorable environment of the textured implant surface, producing a bacterial load that elicits a chronic inflammatory response. Bacterial antigens, primarily of Gram-negative origin, may trigger innate immunity and induce T-cell proliferation with subsequent malignant transformation in genetically susceptible individuals. Although much remains to be elucidated regarding the multifactorial origins of BIA-ALCL, future research should focus on prevention and treatment strategies, recognizing susceptible populations, and whether decreasing the risk of BIA-ALCL is possible.
Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment
Authors: Campaner Elena , Zannini Alessandro , Santorsola Mariangela , Bonazza Deborah , Bottin Cristina , Cancila Valeria , Tripodo Claudio , Bortul Marina , Zanconati Fabrizio , Schoeftner Stefan , Del Sal Giannino
Published: December 2020

Tumor organoids are tridimensional cell culture systems that are generated in vitro from surgically resected patients’ tumors. They can be propagated in culture maintaining several features of the tumor of origin, including cellular and genetic heterogeneity, thus representing a promising tool for precision cancer medicine. Here, we established patient-derived tumor organoids (PDOs) from different breast cancer subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched, and triple negative). The established model systems showed histological and genomic concordance with parental tumors. However, in PDOs, the ratio of diverse cell populations was frequently different from that originally observed in parental tumors. We showed that tumor organoids represent a valuable system to test the efficacy of standard therapeutic treatments and to identify drug resistant populations within tumors. We also report that inhibitors of mechanosignaling and of Yes-associated protein 1 (YAP) activation can restore chemosensitivity in drug resistant tumor organoids.
Dark Matter of Primate Genomes: Satellite DNA Repeats and Their Evolutionary Dynamics
Authors: Ahmad Syed Farhan , Singchat Worapong , Jehangir Maryam , Suntronpong Aorarat , Panthum Thitipong , Malaivijitnond Suchinda , Srikulnath Kornsorn
Published: December 2020

A substantial portion of the primate genome is composed of non-coding regions, so-called “dark matter”, which includes an abundance of tandemly repeated sequences called satellite DNA. Collectively known as the satellitome, this genomic component offers exciting evolutionary insights into aspects of primate genome biology that raise new questions and challenge existing paradigms. A complete human reference genome was recently reported with telomere-to-telomere human X chromosome assembly that resolved hundreds of dark regions, encompassing a 3.1 Mb centromeric satellite array that had not been identified previously. With the recent exponential increase in the availability of primate genomes, and the development of modern genomic and bioinformatics tools, extensive growth in our knowledge concerning the structure, function, and evolution of satellite elements is expected. The current state of knowledge on this topic is summarized, highlighting various types of primate-specific satellite repeats to compare their proportions across diverse lineages. Inter- and intraspecific variation of satellite repeats in the primate genome are reviewed. The functional significance of these sequences is discussed by describing how the transcriptional activity of satellite repeats can affect gene expression during different cellular processes. Sex-linked satellites are outlined, together with their respective genomic organization. Mechanisms are proposed whereby satellite repeats might have emerged as novel sequences during different evolutionary phases. Finally, the main challenges that hinder the detection of satellite DNA are outlined and an overview of the latest methodologies to address technological limitations is presented.
HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3–miR124 Axis
Authors: Thakuri Bal Krishna Chand , Zhang Jinyu , Zhao Juan , Nguyen Lam N. , Nguyen Lam N. T. , Schank Madison , Khanal Sushant , Dang Xindi , Cao Dechao , Lu Zeyuan , Wu Xiao Y. , Jiang Yong , El Gazzar Mohamed , Ning Shunbin , Wang Ling , Moorman Jonathan P. , Yao Zhi Q.
Published: December 2020

RUNX1 overlapping RNA (RUNXOR) is a long non-coding RNA and plays a pivotal role in the differentiation of myeloid cells via targeting runt-related transcription factor 1 (RUNX1). We and others have previously reported that myeloid-derived suppressor cells (MDSCs) expand and inhibit host immune responses during chronic viral infections; however, the mechanisms responsible for MDSC differentiation and suppressive functions, in particular the role of RUNXOR–RUNX1, remain unclear. Here, we demonstrated that RUNXOR and RUNX1 expressions are significantly upregulated and associated with elevated levels of immunosuppressive molecules, such as arginase 1 (Arg1), inducible nitric oxide synthase (iNOS), signal transducer and activator of transcription 3 (STAT3), and reactive oxygen species (ROS) in MDSCs during chronic hepatitis C virus (HCV) infection. Mechanistically, we discovered that HCV-associated exosomes (HCV-Exo) can induce the expressions of RUNXOR and RUNX1, which in turn regulates miR-124 expression via STAT3 signaling, thereby promoting MDSC differentiation and suppressive functions. Importantly, overexpression of RUNXOR in healthy CD33+ myeloid cells promoted differentiation and suppressive functions of MDSCs. Conversely, silencing RUNXOR or RUNX1 expression in HCV-derived CD33+ myeloid cells significantly inhibited their differentiation and expressions of suppressive molecules and improved the function of co-cultured autologous CD4 T cells. Taken together, these results indicate that the RUNXOR–RUNX1–STAT3–miR124 axis enhances the differentiation and suppressive functions of MDSCs and could be a potential target for immunomodulation in conjunction with antiviral therapy during chronic HCV infection.
Endothelial Protease Activated Receptor 1 (PAR1) Signalling Is Required for Lymphocyte Transmigration across Brain Microvascular Endothelial Cells
Authors: Dragoni Silvia , Papageorgiou Anna , Araiz Caroline , Greenwood John , Turowski Patric
Published: December 2020

Lymphocyte transendothelial migration (TEM) relies on ICAM-1 engagement on the luminal surface of the endothelial cells (ECs). In blood–brain barrier (BBB) ECs, ICAM-1 triggers TEM signalling, including through JNK MAP kinase and AMP-activated protein kinase (AMPK), which lead to the phosphorylation and internalisation of the adherens junction protein VE-cadherin. In addition to ICAM-1, G protein-coupled receptors (GPCRs) are also required for lymphocytes TEM across BBB ECs. Here, we investigated the role of protease activated GPCRs (PARs) and found a specific role for PAR1 in support of lymphocyte TEM across BBB ECs in vitro. PAR1 requirement for TEM was confirmed using protease inhibitors, specific small molecule and peptide antagonists, function blocking antibodies and siRNA-mediated knockdown. In BBB ECs, PAR1 stimulation led to activation of signalling pathways essential to TEM; notably involving JNK and endothelial nitric oxide synthase (eNOS), with the latter downstream of AMPK. In turn, nitric oxide production through eNOS was essential for TEM by modulating VE-cadherin on Y731. Collectively, our data showed that non-canonical PAR1 activation by a lymphocyte-released serine protease is required for lymphocyte TEM across the BBB in vitro, and that this feeds into previously established ICAM-1-mediated endothelial TEM signalling pathways.
Exploratory Sampling of Spalting Fungi in the Southern Peruvian Amazon Forest
Authors: Vega Gutierrez Sarath M. , Illescas Guevara Javier F. , Andersen Claudia C. , Koechlin von Stein Jose , Robinson Seri C.
Published: December 2020

Most of the research related to Peruvian Amazon fungi is focused on edible mushrooms and pathogens. Other important fungi, such as the spalting type (decay fungi that pigment wood internally), are not broadly studied, as most of them do not produce fruiting bodies and can be difficult to locate. Spalting fungi, however, are of broad economic importance due to their ability to produce pigments that enhance wood aesthetics, resulting in an increased economic value. In order to begin understanding the diversity of spalting fungi within certain regions of the Amazon, a sampling of downed trees and branches (through the opening of the xylem to identify potential pigmenting and zone line producing fungi) was done in the district of Las Piedras, Madre de Dios, Peru. Fungi suspected of causing internal pigment and zone lines were collected, cultured, isolated, and sequenced. The species found belonged to the orders Helotiales, Xylariales, Hypocreales, Russulales, Polyporales, Botryosphaeriales and two specimens of the class Leotiomycetes. The fungi collected produced pigments or zone lines in wild conditions and all of them were capable of wood decomposition. Interestingly, these are the same orders and genera as North American spalting fungi, which may indicate a correlation within species that pigment wood. The results obtained start a specific database of spalted fungi in the Amazon and, with it, help support an effort to increase the forest value of ecosystems primarily used for a few high-valued tree species.
Laser Shock Induced Deformation of Copper Foil on Diverse Molds and the Cross-Sectional Microstructure Changes
Authors: Huang Di , Man Jiaxiang
Published: December 2020

The microscale structures prepared on copper foil by laser shock deformation was introduced in the paper. The various sizes of hexagonal structures were successfully fabricated on copper foil with different molds. The influence of laser energy on the deformation depth of a hexagonal structure was studied using experiments. The morphology of the hexagonal structures on copper foil was observed by a three-dimensional profilometer, and mechanical property were characterized by a nanoindenter. A finite element model was established in order to describe the copper foil forming mechanism on mold and calculate the residual stress distribution. The microstructures and cross-section deformation of copper foil on different molds were also observed. The results indicated that the depth of hexagonal structures on 50# mold was higher than that of the structures on 100# mold and 230# mold, and the depth of hexagonal structures increased with the increasing of pulse laser energy. The copper foil above the mold hexagon side was bent and thinned after laser shock, and the grains of copper foil were also refining. The mechanical properties of copper foil were improved after laser shock was performed on the mold.
Junction-Producing Algorithm Connecting Carbon Nanotube to Carbon Nanocone to Obtain Funnel-Like Nanostructure: Nanochimney Generator
Authors: Muraru Sorin
Published: December 2020

This study aims to provide a computational algorithm which contributes to the understanding and implementation of carbon nanochimneys. The structure resembles a tube ending with an inverted funnel, with a connection region that uses non-hexagonal rings as defects in order to match the boundaries of the two linked nanostructures. They are important for applications such as thermal transport, gas storage, or separation. The algorithm is written in Python 3.7 and provides a .pdb file with the coordinates of all the atoms included in the system. The parameters that can be specified are the carbon nanotube dimensions, for either armchair or zigzag conformations, five levels of disclination for the carbon nanocone along with the base diameter of the latter.
Effects of the Domain Wall Conductivity on the Domain Formation under AFM-Tip Voltages in Ion-Sliced LiNbO3 Films
Authors: Gainutdinov Radmir , Volk Tatyana
Published: December 2020

The specified domain patterns were written by AFM-tip voltages in LiNbO3 films composing LNOI (LiNbO3-on-insulator). The domain wall conductivity (DWC) was estimated in the written patterns. This estimate was based on the effects of load resistors RL inserted between DWs and the ground, on the features of occurring domains. In this case, the domain formation is controlled by the ratio between RL and the DWs’ resistance RDW. Starting from the comparison of patterns appearing at different RL, the value of RDW in a specified pattern was estimated. The corresponding DWC is of σDW ≈ 10−3 (Ohm cm)−1 which exceeds the tabular bulk conductivity of LiNbO3 by no less than twelve orders of magnitude. A small DW inclination angle of (10−4)0 responsible for this DWC is not caused by any external action and characterizes the domain frontal growth under an AFM-tip voltage.
Chiral Photoresponsive Liquid Crystalline Materials Derived from Cyanoazobenzene Central Core: Effect of UV Light Illumination on Mesomorphic Behavior
Authors: Poryvai Anna , Bubnov Alexej , Kohout Michal
Published: December 2020

One of the most frequently utilized liquid crystalline (LC) materials is a rod-like (calamitic) compound 4-cyano-4′-pentylbiphenyl (5-CB). The main objective of this work is to enhance its functionality by introducing a photoresponsive diazenyl spacer in the aromatic core and replace the non-chiral pentyl chain with various chiral alkyl carboxylate units. The mesomorphic properties of the prepared materials have been studied using polarizing optical microscopy and differential scanning calorimetry. It has been found that materials with an extended aromatic system possess the liquid crystalline behavior. The studied LC materials have shown mesophases at lower temperatures than previously reported analogous substances. Furthermore, one of them exhibits a chiral orthogonal frustrated twist grain boundary smectic phase, which has not been previously observed for this structural type of materials. We also investigated photoresponse of the mesophases under illumination with UV-light (365 nm) using a polarizing optical microscope. A non-conventional photoresponse of the prepared materials in a crystalline phase is presented and discussed.
Data Science: Measuring Uncertainties
Authors: de Braganca Pereira Carlos Alberto , Polpo Adriano , Rodrigues Agatha Sacramento
Published: December 2020

With the increase in data processing and storage capacity, a large amount of data is available [...]
Analytical-Numerical Approach to the Skin and Proximity Effect in Lines with Round Parallel Wires
Authors: Jabłoński Paweł , Kusiak Dariusz , Szczegielniak Tomasz
Published: December 2020

Power and communication lines with round wires are often used in electrical engineering. The skin and proximity effects affect the current density distribution and increase resistances and energy losses. Many approaches were proposed to calculate the effects and related quantities. One of the simplest approximate closed solutions neglects the dimensions of neighboring wires. In this paper, a solution to this problem is proposed based on the method of successive reactions. In this context, the solution with substitutive filaments is considered as the first approximation of the true solution. Several typical arrangements of wires in single-phase communication lines or three-phase bus ducts are considered to detect the limits of applicability of the first approximation. The error of the first approximation grows with wire radius to skin depth ratio and wire radius to wire spacing ratio. When the wire radius to skin depth ratio is up to 1, and the gap between the wires is above the wire radius, the error is at a level of 1%. However, lowering the distance and/or skin depth leads to a much larger error in the first approximation.
Reducing Rotor Temperature Rise in Concentrated Winding Motor by Using Magnetic Powder Mixed Resin Ring
Authors: Sato Mitsuhide , Takazawa Keigo , Horiuchi Manabu , Masuda Ryoken , Yoshida Ryo , Nirei Masami , Bu Yinggang , Mizuno Tsutomu
Published: December 2020

The demand for high-speed servomotors is increasing, and minimal losses in both high-speed and high-torque regions are required. Copper loss reduction in permanent magnet motors can be achieved by configuring concentrated winding, but there are more spatial harmonics compared with distributed winding. At high-speed rotation, the eddy current loss of the rotor increases, and efficiency tends to decrease. Therefore, we propose a motor in which a composite ring made from resin material mixed with magnetic powder is mounted on the stator to suppress spatial harmonics. This paper describes three characteristic motor types, namely, open-slot motors, composite-ring motors, and closed-slot motors. Spatial harmonics are reduced significantly in composite-ring motors, and rotor eddy current loss is reduced by more than 50% compared with open-slot motors. Thermal analysis suggests that the saturation temperature rise value is reduced by more than 30 K. The use of a composite ring is effective in reducing magnet eddy current loss during high-speed rotation. Conversely, the torque characteristics in the closed-slot motor are greatly reduced as well as the efficiency. Magnetic circuits and simulations show that on electrical steel sheets with high relative permeability, the ring significantly reduces the torque flux passing through the stator, thus reducing the torque constant. To achieve reduced eddy current loss during high-speed rotation while ensuring torque characteristics with the composite ring, it is necessary to set the relative permeability and thickness of the composite ring according to motor specifications.
Modeling Study on Heat Transfer in Marangoni Dropwise Condensation for Ethanol-Water Mixture Vapors
Authors: Wang Jinshi , Ma Ziqiang , Li Yong , Liu Weiqi , Li Gen
Published: December 2020

In this paper, a model was developed to predict the heat transfer characteristics of Marangoni dropwise condensation. In accordance with the feature of Marangoni condensation, condensation was treated as dropwise condensation of mixture vapors. The condensation space was divided into two parts: the vapor diffusion layer and the condensate layer. For the condensate layer, the classical heat transfer calculation method of dropwise condensation was imitated to obtain the heat transfer characteristics. For the vapor diffusion layer, the heat transfer characteristics were achieved by solving the conservation equations. These heat transfer characteristics were coupled through the conjunct boundary, which was the vapor-liquid interface. The model was applied to the condensation of water-ethanol mixture vapors. A comparison with the existing experimental data showed that the developed model could basically reflect the influences of vapor-to-surface temperature difference, vapor concentration, vapor pressure, and vapor velocity on heat transfer characteristic of Marangoni condensation. Results showed that some differences existed between the calculation results and experimental results, but the prediction deviation of the model could be acceptable in the range of vapor-to-surface temperature difference where the condensation heat transfer coefficients reached peak values.
Small Hydropower in the Baltic States—Current Status and Potential for Future Development
Authors: Kasiulis Egidijus , Punys Petras , Kvaraciejus Algis , Dumbrauskas Antanas , Jurevičius Linas
Published: December 2020

Small hydropower (SHP) plays an important role in the Baltic States as a reliable and efficient source of electricity from renewable sources. This study presents the historical development, current status, and possible trends for the future development of SHP in the Baltic States with insights into the legal background and development policies for SHP in Estonia, Latvia and Lithuania. For the assessment of hydraulic structures in the Baltic States, the historical data was used supplemented with data from hydropower associations, the national departments of statistics, electricity transmission systems operators, etc. The currently recommended best practice for SHP development is the utilisation of existing sites with available infrastructure. These include old water mill sites and existing dam sites, which, in the Baltic States, number more than 1500. The majority of these sites have their power potential attributed to micro-hydro (<100 kW). In this study the potential of the hydropower capacity at historic, currently nonpowered dams is evaluated and the distribution of the micro-hydro sites within the EU network of protected areas under Natura 2000 and nationally designated areas is presented. The potential electricity generation from such historic sites in the Baltic States is more than 200 GWh/year.
Investigation of the Physico-Chemical Properties of the Products Obtained after Mixed Organic-Inorganic Leaching of Spent Li-Ion Batteries
Authors: Urbańska Weronika , Osial Magdalena
Published: December 2020

Lithium-ion batteries are currently one of the most important mobile energy storage units for portable electronics such as laptops, tablets, smartphones, etc. Their widespread application leads to the generation of large amounts of waste, so their recycling plays an important role in environmental policy. In this work, the process of leaching with sulfuric acid for the recovery of metals from spent Li-ion batteries in the presence of glutaric acid and hydrogen peroxide as reducing agents is presented. Experimental results indicate that glutaric-acid application improves the leaching performance compared to the use of just hydrogen peroxide under the same conditions. Obtained samples of leaching residues after mixed inorganic-organic leaching were characterized with Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, and X-ray diffraction.
Combined Multi-Layer Feature Fusion and Edge Detection Method for Distributed Photovoltaic Power Station Identification
Authors: Jie Yongshi , Ji Xianhua , Yue Anzhi , Chen Jingbo , Deng Yupeng , Chen Jing , Zhang Yi
Published: December 2020

Distributed photovoltaic power stations are an effective way to develop and utilize solar energy resources. Using high-resolution remote sensing images to obtain the locations, distribution, and areas of distributed photovoltaic power stations over a large region is important to energy companies, government departments, and investors. In this paper, a deep convolutional neural network was used to extract distributed photovoltaic power stations from high-resolution remote sensing images automatically, accurately, and efficiently. Based on a semantic segmentation model with an encoder-decoder structure, a gated fusion module was introduced to address the problem that small photovoltaic panels are difficult to identify. Further, to solve the problems of blurred edges in the segmentation results and that adjacent photovoltaic panels can easily be adhered, this work combines an edge detection network and a semantic segmentation network for multi-task learning to extract the boundaries of photovoltaic panels in a refined manner. Comparative experiments conducted on the Duke California Solar Array data set and a self-constructed Shanghai Distributed Photovoltaic Power Station data set show that, compared with SegNet, LinkNet, UNet, and FPN, the proposed method obtained the highest identification accuracy on both data sets, and its F1-scores reached 84.79% and 94.03%, respectively. These results indicate that effectively combining multi-layer features with a gated fusion module and introducing an edge detection network to refine the segmentation improves the accuracy of distributed photovoltaic power station identification.
Study on Process Derivation and Characteristic Analysis for BLDC Motor Design Using Dual Rotor Structure with High Torque Density
Authors: Lee Byeong-Chul , Song Cheon-Ho , Kim Do-Hyun , Kim Ki-Chan
Published: December 2020

In this paper, the design process of brushless DC (BLDC) motor adopting the dual rotor structure that can reduce the overall size of the motor while generating the same torque as the conventional permanent magnet BLDC motor is analyzed. A simple size is selected by obtaining the torque per rotor volume (TRV), and a method of matching the counter electromotive force by selecting the pole-arc of the magnet through a magnetic equivalent circuit is analyzed. Since the efficiency is low because the 120-degree commutation method is selected, the middle stator is optimized through detailed design through the experimental design method. Afterwards, it has the advantage of being able to shift without stopping due to the characteristic of a dual rotor. For this, an analysis of the driving characteristics for each mode is performed.
Evaluating the Economic Incentives of Biomass Removal on Site Preparation for Different Harvesting Systems in Australia
Authors: Berry Michael , Sessions John
Published: December 2020

Research Highlights: This study evaluated the impacts of biomass recovery on site preparation costs while proposing a mathematical model and framework to catalogue the benefits depending on harvesting system. Background and Objectives: Biomass as a viable product depends on the requisite costs of production compared to the price paid by relative markets. The removal of biomass directly impacts site preparation costs, and the operational and economic ramifications of this should inform the feasibility of biomass harvesting and market viability. The relative incentives for biomass removal depend on the quantity, presentation, and location of the residues and are thus a result of the commercial sawlog harvesting system. This incentive also largely depends on the required work to prepare a site for replanting. Materials and Methods: This study developed a mathematical model to connect the concepts of site preparation, harvesting, and biomass costs and revenues to determine the maximum net revenue. This work also developed a framework for understanding and calculating the key model inputs related to site preparation and the relative economic site preparation incentive for biomass harvesting. The framework was then illustrated by using industry data from plantations in Queensland, Australia. Results and Conclusions: The analysis identified a potential reduction in site preparation costs due to biomass harvesting of USD 75–450 ha−1, with a greater incentive when using cut-to-length harvesting systems compared with whole-tree harvesting due to the greater volume of residues after cut-to-length harvesting. For example, a removal of 20 t ha−1 of recoverable biomass after cut-to-length harvesting may equate to an economic incentive of USD 22 t−1. Depending on the biomass market, this incentive may represent a significant percentage (or even exceed) the biomass market price. The combination of biomass market price plus site preparation economic incentive may make biomass an attractive market opportunity, even in challenging biomarkets.
RAM-PGK: Prediction of Lysine Phosphoglycerylation Based on Residue Adjacency Matrix
Authors: Chandra Abel Avitesh , Sharma Alok , Dehzangi Abdollah , Tsunoda Tatushiko
Published: December 2020

Background: Post-translational modification (PTM) is a biological process that is associated with the modification of proteome, which results in the alteration of normal cell biology and pathogenesis. There have been numerous PTM reports in recent years, out of which, lysine phosphoglycerylation has emerged as one of the recent developments. The traditional methods of identifying phosphoglycerylated residues, which are experimental procedures such as mass spectrometry, have shown to be time-consuming and cost-inefficient, despite the abundance of proteins being sequenced in this post-genomic era. Due to these drawbacks, computational techniques are being sought to establish an effective identification system of phosphoglycerylated lysine residues. The development of a predictor for phosphoglycerylation prediction is not a first, but it is necessary as the latest predictor falls short in adequately detecting phosphoglycerylated and non-phosphoglycerylated lysine residues. Results: In this work, we introduce a new predictor named RAM-PGK, which uses sequence-based information relating to amino acid residues to predict phosphoglycerylated and non-phosphoglycerylated sites. A benchmark dataset was employed for this purpose, which contained experimentally identified phosphoglycerylated and non-phosphoglycerylated lysine residues. From the dataset, we extracted the residue adjacency matrix pertaining to each lysine residue in the protein sequences and converted them into feature vectors, which is used to build the phosphoglycerylation predictor. Conclusion: RAM-PGK, which is based on sequential features and support vector machine classifiers, has shown a noteworthy improvement in terms of performance in comparison to some of the recent prediction methods. The performance metrics of the RAM-PGK predictor are: 0.5741 sensitivity, 0.6436 specificity, 0.0531 precision, 0.6414 accuracy, and 0.0824 Mathews correlation coefficient.
The Impact of and Interaction between Diabetes and Frailty on Psychosocial Wellbeing and Mortality in Ireland
Authors: O’Donovan Mark , Sezgin Duygu , O’Caoimh Rónán , Liew Aaron
Published: December 2020

Frailty in middle-aged and older adults is associated with diabetes-related complications. The impact of and interaction between diabetes and frailty on psychosocial wellbeing and mortality in Ireland for adults aged ≥50 years were assessed using data from the Survey of Health, Ageing and Retirement in Europe. Measures included diabetes status (self-reported), frailty phenotype (≥3/5 criteria), low self-rated health (“fair” or “poor”), depression screening (EURO-D index score ≥4), and low quality of life (QoL) (CASP-12 index score < 35). Among the 970 participants, those with diabetes (n = 87) were more likely to be frail (23% vs. 8%; p < 0.001), have low self-rated health (46% vs. 19%; p < 0.001), depression (25% vs. 17%; p = 0.070), and low QoL (25% vs. 18%, p = 0.085). Adjusting for diabetes, age and sex, frailty independently predicted low self-rated health (OR: 9.79 (5.85–16.36)), depression (9.82 (5.93–16.25)), and low QoL (8.52 (5.19–13.97)). Adjusting for frailty, age and sex, diabetes independently predicted low self-rated health (2.70 (1.63–4.47)). The age-sex adjusted mortality hazard ratio was highest for frailty with diabetes (4.67 (1.08–20.15)), followed by frailty without diabetes (2.86 (1.17–6.99)) and being non-frail with diabetes (1.76 (0.59–5.22)). Frailty independently predicts lower self-reported wellbeing and is associated with reduced survival, underpinning its role as an integral part of holistic diabetes care.
Incidence and Survival Trends of Pancreatic Cancer in Girona: Impact of the Change in Patient Care in the Last 25 Years
Authors: García-Velasco Adelaida , Zacarías-Pons Lluís , Teixidor Helena , Valeros Marc , Liñan Raquel , Carmona-Garcia M. Carmen , Puigdemont Montse , Carbajal Walter , Guardeño Raquel , Malats Núria , Duell Eric , Marcos-Gragera Rafael
Published: December 2020

(1) Background: We investigated the incidence and survival trends for pancreatic cancer (PC) over the last 25 years in the Girona region, Catalonia, Spain; (2) Methods: Data were extracted from the population-based Girona Cancer Registry. Incident PC cases during 1994–2015 were classified using the International Classification of Diseases for Oncology Third Edition (ICD-O-3). Incidence rates age-adjusted to the European standard population (ASRE) and world standard population (ASRW) were obtained. Trends were assessed using the estimated annual percentage of change (EAPC) of the ASRE13. Observed and relative survivals (RS) were estimated with the Kaplan–Meier and Pohar Perme methods, respectively; (3) Results: We identified 1602 PC incident cases. According to histology, 44.4% of cases were exocrine PC, 4.1% neuroendocrine, and 51.1% malignant-non-specified. The crude incidence rate (CR) for PC was 11.43 cases-per-100,000 inhabitants/year. A significant increase of incidence with age and over the study period was observed. PC overall 5-year RS was 7.05% (95% confidence interval (CI) 5.63; 8.84). Longer overall survival was observed in patients with neuroendocrine tumours (5-year RS 61.45%; 95% CI 47.47; 79.55). Trends in 5-year RS for the whole cohort rose from 3.27% (95% CI 1.69–6.35) in 1994–1998 to 13.1% (95% CI 9.98; 17.2) in 2010–2015; (4) Conclusions: Incidence rates of PC in Girona have increased in the last two decades. There is a moderate but encouraging increase in survival thorough the study period. These results can be used as baseline for future research.
Depressed Mood after Stroke: Predictive Factors at Six Months Follow-Up
Authors: López-Espuela Fidel , Roncero-Martín Raúl , Canal-Macías Maria de la Luz , Moran Jose M. , Vera Vicente , Gomez-Luque Adela , Lendinez-Mesa Alejandro , Pedrera-Zamorano Juan Diego , Casado-Naranjo Ignacio , Lavado-García Jesus
Published: December 2020

We aimed to know the prevalence of post-stroke depression (PSD) in our context, identify the variables that could predict post-stroke depression, by using the Hamilton Depression Rating Scale, occurring within six months after stroke, and identify patients at high risk for PSD. Methods: descriptive, cross-sectional and observational study. We included 173 patients with stroke (transient ischemic attack (TIA) included) and collected sociodemographic and clinical variables. We used the Hamilton Depression Scale (HDS) for depression assessment and Barthel Index and modified Rankin Scale (mRS) for functional assessment. The neurological severity was evaluated by the National Institutes of Health Stroke Scale (NIHSS). Results: 35.5% were women, aged 71.16 (±12.3). Depression was present in 42.2% patients (n = 73) at six months after stroke. The following variables were significantly associated with PSD: diagnosis of previous depression (p = 0.005), the modified Rankin Scale at discharge (p = 0.032) and length of hospital stay (p = 0.012). Conclusion: PSD is highly prevalent after stroke and is associated with the severity, left location of the stroke, and the degree of disability at discharge. Its impact justifies the evaluation and early treatment that still continues to be a challenge today.
A Study on the Current Situation of Prearranged Shelter Management in Japan for Making a Standard Operation Procedure
Authors: Yasui Arisa , Numada Muneyoshi , Bando Makoto , Nakano Shintaro , Krishna Chaitanya
Published: December 2020

To establish a standard operation procedure (SOP) for shelter management, this research analyzed current situations about shelter management in Japanese local governments, focusing on designation of shelters, operation manager and information sharing. The results indicate that some have non-designated shelters, which might lead to differences of support with designated shelters, local governments ask residents to operate shelters mainly, but this requirement is not shared among them, and system of information sharing is not developed primarily with the department of health and welfare. Besides, this research shows the importance of including the closing and after the closing of the shelters.
Development and Validation of Breadcrumbing in Affective-Sexual Relationships (BREAD-ASR) Questionnaire: Introducing a New Online Dating Perpetration
Authors: Rodríguez-García Mª Carmen , Márquez-Hernández Verónica V. , Granados-Gámez Genoveva , Aguilera-Manrique Gabriel , Martínez-Puertas Helena , Gutiérrez-Puertas Lorena
Published: December 2020

New technologies are changing people’s lifestyles and in turn, their way of relating to and interacting with others. Breadcrumbing is one of the new 2.0 concepts linked to the virtual relationship paradigm. This study aimed to design and psychometrically test the Breadcrumbing in Affective-Sexual Relationships (BREAD-ASR) Questionnaire to explore breadcrumbing perpetration in adolescent relationships online. A total of 247 adolescents participated in a paper-and-pencil survey carried out from March to June 2019 in a high school in southeastern Spain. Psychometric analysis showed a satisfactory content and construct validity for the instrument. The ordinal alpha coefficient was 0.83, indicating the BREAD-ASR questionnaire had good internal consistency. The BREAD-ASR questionnaire constitutes a valid and reliable instrument which can be used by health professionals in screenings for breadcrumbing perpetration and to design effective prevention and intervention programs in the community, which may help and support adolescents and families to deal with new forms of online relationships and perpetration successfully.
Keeping Low Reproductive Number Despite the Rebound Population Mobility in Korea, a Country Never under Lockdown during the COVID-19 Pandemic
Authors: Kim Soyoung , Kim Yae-Jean , Peck Kyong Ran , Ko Youngsuk , Lee Jonggul , Jung Eunok
Published: December 2020

Nonpharmaceutical intervention has been one of the most important strategies to prevent the spread of the SARS-CoV-2 in the communities during the COVID-19 pandemic. Korea has a unique experience that we had the first large outbreak during the early pandemic and could flatten the epidemic curve without lockdown. In this study, the effective reproductive numbers were calculated for the entire nation and Seoul (the capital city) Metropolitan Area from February 16–15 July, where 60% of the population reside. We compared the changes in population mobility data and reproductive number trends according to the changes in the government’s nonpharmaceutical intervention strategy. The total daily mobility decreased when Korea had the first wave of a large outbreak in February–March 2020, which was mainly caused by the decrease of daily noncommuting mobility. However, daily commuting mobility from 16 February to 30 June 2020 was maintained at a similar level since there was no national lockdown for workers who commute between home and work. During the first half-year of 2020, Korea could control the outbreak to a manageable level without a significant decrease in daily public mobility. However, it may be only possible when the public follows personal hygiene principles and social distancing without crisis fatigue or reduced compliance.
Changes in the Electrical Activity of the Brain in the Alpha and Theta Bands during Prayer and Meditation
Authors: Dobrakowski Paweł , Blaszkiewicz Michal , Skalski Sebastian
Published: December 2020

Focused attention meditation (FAM) is a category of meditation based on an EEG pattern, which helps the wandering mind to focus on a particular object. It seems that prayer may, in certain respects, be similar to FAM. It is believed that emotional experience correlates mainly with theta, but also with selective alpha, with internalized attention correlating mainly with the synchronous activity of theta and alpha. The vast majority of studies indicate a possible impact of transcendence in meditation on the alpha wave in EEG. No such reports are available for prayer. Seventeen women and nineteen men aged 27–64 years with at least five years of intensive meditation/prayer experience were recruited to participate in the study. We identified the two largest groups which remained in the meditation trend originating from the Buddhist system (14 people) (Buddhist meditators) and in the Christian-based faith (15 people) (Christian meditators). EEG signal was recorded with open eyes, closed eyes, during meditation/prayer, and relaxation. After the EEG recording, an examination was conducted using the Scale of Spiritual Transcendence. Buddhist meditators exhibited a statistically significantly higher theta amplitude at Cz during meditation compared to relaxation. Meanwhile, spiritual openness favored a higher theta amplitude at Pz during relaxation. Our study did not reveal statistically significant differences in frontal areas with regard to alpha and theta, which was often indicated in previous studies. It seems necessary to analyze more closely the midline activity in terms of dispersed neural activity integration.