bluuebunny/crossref_metadata_2025 huggingface dataset:
Desafios do Desenvolvimento Nacional Sustentável em licitações públicas
Authors: Carvalho Amanda Bezerra de , Silva Heibe Santana da
Published: March 2023

O presente artigo apresenta uma revisão do tipo integrativa, sobre a produção científica brasileira, a respeito da temática sustentabilidade em licitações públicas. A busca foi realizada em periódicos científicos indexados nas bases SciELO e Google Scholar, publicadas durante os anos de 2015 a 2021 em língua portuguesa, empregando os descritores “desenvolvimento sustentável”, “sustentabilidade”, “compras públicas” e “licitações públicas” com o auxílio do conectivo “AND”. Para o tratamento dos dados, utilizou-se o software Iramuteq. As análises reafirmam a necessidade de maiores aprofundamentos sobre o plano prático da implementação dos princípios e dimensões que objetivam o Desenvolvimento Sustentável em licitações públicas, diante da constante emergência por mudanças.
Sputum Interleukin-32 in childhood asthma: correlation with IL-1β
Authors: Louhaichi Sabrine , Cherif Tarak , Hamdi Besma , Hamzaoui Kamel , Hamzaoui Agnes
Published: March 2023

_Background:_ Asthma is an airway disorder where inflammatory cytokines are partly responsible for exacerbating the disease. Interleukin (IL)-32, generally referred to as natural killer cell (NK4) transcript 4, is described as an immunoregulator involved in the stimulation of anti-/pro-inflammatory cytokines. The abnormal presence of IL-32 has been observed during inflammatory diseases, particularly in asthma. This study aims to characterize IL-32 in the inflammatory process in patients with severe asthma.
_Methods:_ IL-32 and IL-1β levels in the supernatant of induced sputum obtained from 59 asthma patients (mild: 20 patients; moderate: 20 patients; severe: 19 patients) were measured using ELISA. Sputum IL-32 mRNA expression was measured by RT- PCR.
_Results:_ Sputum IL-32 was significantly elevated at the protein (_p= 0.00019_) and mRNA expression (_p < 0.0001_) in asthmatics compared to non-asthmatic controls. IL-32 was elevated in severe asthmatic patients (_p < 0.0001_) compared to mild-moderate asthma. Severe asthmatics allergic to house dust mites expressed higher sputum IL-32 levels than severe asthmatics without allergy (_p = 0.0001_). A significant association was found between sputum IL-32 and IL-32 mRNA (r =0.531_; p = 0.0159_) in severe asthma. In the same way, sputum IL-1β and IL-32 were significantly correlated (r = 0.476; _p = 0.0337_).
_Conclusion:_ The level of IL-32 in induced sputum may be associated with asthma severity.
Bell's theorem is an exercise in the statistical theory of causality
Authors: Gill Richard
Published: March 2023

In this short note, I derive the Bell-CHSH inequalities as an elementary result in the present-day theory of statistical causality based on graphical models or Bayes' nets, defined in terms of DAGs (Directed Acyclic Graphs) representing direct statistical causal influences between a number of observed and unobserved random variables. I show how spatio-temporal constraints in loophole-free Bell experiments, and natural classical statistical causality considerations, lead to Bell's notion of local hidden variables, and thence to the CHSH inequalities. The word “local” applies to the way that the chosen settings influence the observed outcomes. The case of contextual setting-dependent hidden variables (thought of as being located in the measurement devices and dependent on the measurement settings) is automatically covered, despite recent claims that Bell's conclusions can be circumvented in this way.
Studies of the physical and mechanical properties of the composition obtained on the basis of polyvinyl chloride, synthetic rubber ethylene propylene terpolymer, and plasticizer
Authors: Shixaliyev Kerem
Published: March 2023

The properties of mixtures and vulcanizates of polyvinyl chloride (PVC) and synthetic rubber of ethylene-propylene terpolymer (SREPT) have been studied. The physical and mechanical properties of vulcanizates have been studied. Thus, a vulcanizate based on a mixture of PVC with synthetic rubber of ethylene propylene terpolymer has a higher oil and petrol resistance than a vulcanizate based on unmodified SREPT. It became known that 10 mass. spare parts in synthetic rubber ethylene-propylene terpolymer PVX are optimal for modification. synthetic rubber-based ethylene propylene terpolymer. 30 mass parts and when turned on, the degree of swelling of the vulcanizate decreases in gasoline by 2.7 times, in a mixture of gasoline-benzene (3:1) by 2.3 times, and in Avtol-10 oil by 3.2 times
TOLERANCE OF MARANDU GRASS TO EXCESS IRON AND MANGANESE
Authors: Caione Gustavo , Marques Campos Luana , Tsuyoshi Kume Willian , Ferreira Ferbonink Guilherme , De Oliveira Caione Daniele Fátima
Published: March 2023

In soaked soils there is an increase in the availability of iron and manganese. Thus, it becomes important to investigate the tolerance levels of plants to excess of these nutrients. The objective was to evaluate the tolerance of Urochloa brizantha cv. Marandu cultivated in nutrient solution with different levels of iron and manganese. The experimental design was completely randomized with seven treatments and four replications. The treatments consisted of a nutrient solution and consisted of: 1- adequate concentration of Fe (8.22 mM) and Mn (2.05 mM); 2– Fe, four times the adequate concentration; 3– Fe, eight times the adequate concentration; 4– Mn, four times the adequate concentration; 5– Mn, eight times the adequate concentration; 6– Fe and Mn, four times the appropriate concentration, and; 7– Fe and Mn, eight times the appropriate concentration. The variables evaluated were visual diagnosis (symptomatology), shoot height, root volume, Fe and Mn content in shoots and dry mass production. Grass plants were not tolerant to excess Fe and Mn. The excess of nutrients promoted less development of the root system, with a reduction in volume and dry mass, and the treatment with the highest dose of nutrients resulted in the lowest values. Grass plants were sensitive to the increase in nutrient concentrations, showing reductions in total dry mass production of 55% for treatment with the application of the highest concentration of nutrients in relation to the adequate dose of Fe and Mn.
Pengelolaan tanaman dan konservasi tanah menentukan tingginya tingkat bahaya erosi di Ujoh Bilang, Mahakam Ulu
Authors: Kamarati Kiamah Fathirizki Agsa , Azwari Fachruddin
Published: March 2023

Kajian ini dilakukan di Kampung Ujoh Bilang, Kecamatan Long Bagun, Kabupaten Mahakam Ulu. Peningkatan jumlah penduduk yang semakin cepat akan berpengaruh pada peningkatan kebutuhan hidup baik secara kuantitas maupun kualitas terhadap penggunaan tanah. Hal tersebut juga berpengaruh terhadap kebutuhan akan lahan untuk berbagai kepentingan manusia yang semakin lama semakin meningkat sehingga terjadi perubahan fungsi lahan. Penelitian ini dilakukan untuk memprediksi nilai erosi dengan menggunakan Metode USLE. Metode tersebut digunakan untuk menilai kehilangan tanah akibat erosi. Parameter yang dianalisis terdiri dari faktor erosivitas limpasan (R), erodibilitas tanah (K), panjang dan kemiringan (LS), pengelolaan tanaman dan konservasi tanah (CP). Berdasarkan data analisis diketahui bahwa Tingkat Bahaya Erosi lokasi penelitian memiliki kategori sangat berat dengan nilai 75,55 ton/ha/th. Perencanaan konservasi pada kawasan tersebut dengan mempertahankan kondisi tanaman penutup tanah dan tetap melakukan penanaman tanaman penutup tanah, sistem penanaman tumpang sari, pembuatan teras gulud searah garis kontur serta pembuatan teras saluran.
Gengibre (Zingiber officinale) no Manejo de Náuseas e Vômitos Induzidos por Quimioterapia em Pacientes com Câncer: Revisão Integrativa da Literatura
Authors: Ferreira Wagner Andrade , Neves Vivian dos Santos , Fiut Maria Angélica , Franco Emília Delesderrier , Rodrigues Cláudia dos Santos Cople
Published: March 2023

Introdução: Náuseas e vômitos induzidos por quimioterapia (NVIQ) são importantes efeitos colaterais dos tratamentos antineoplásicos. Algumas plantas medicinais vêm sendo estudadas no manejo desses efeitos, como o gengibre (Zingiber officinale). Objetivo: Realizar uma revisão acerca do uso via oral do gengibre no manejo de NVIQ em pacientes com câncer. Método: Revisão integrativa da literatura realizada na base de dados MEDLINE, em setembro de 2022, adotando a combinação das palavras-chave “Zingiber officinale” e “Cancer”. Foram também aplicados filtros na seleção para incluir ensaios clínicos aleatórios publicados entre 2012 e 2022. Resultados: Ao todo, foram analisados nove estudos. O gengibre apresenta potencial de reduzir NVIQ em pacientes com câncer, refletindo positivamente na qualidade de vida e na melhora do apetite e da fadiga. Os estudos não observaram efeitos adversos da administração do gengibre. Conclusão: O uso por via oral do gengibre demonstra ser uma estratégia segura para o manejo de NVIQ em pacientes com câncer, na dose de 1 g/dia do gengibre em pó, podendo ser utilizado como terapia complementar juntamente com regimes antieméticos padrões.
Religião e política: a influência da política no voto do religioso
Authors: Silva Samuel Antonio da
Published: March 2023

Nos últimos anos, tem-se observado o estreitamento da relação entre a política e a religião, sob diversas perspectivas. Primeiramente, verifica-se o aumento significativo de religiosos ocupando cargos políticos. As lideranças religiosas, quando ocupam cargos políticos, baseiam seus discursos em certa tradição bíblica, cuja moral separa o certo e o errado, o bem e o mal e, com isso, conquistam o voto dos religiosos. Nesse cenário, o presente artigo tem a finalidade de compreender a relação entre política e religião e como esta influencia os religiosos em suas decisões partidárias. Buscou-se, ainda, através de pesquisa documental, entender quais são os critérios de escolha do candidato por parte dos religiosos, analisando quais são os fatores que os influenciam a fazer a opção política. Utilizou-se, no artigo, a pesquisa bibliográfica, na qual foram buscados e selecionados materiais pertinentes ao tema, de forma embasar teoricamente a discussão proposta. Concluiu-se que, nos últimos anos, houve o crescimento da presença pública de evangélicos no país a partir da entrada na política de candidatos religiosos ou que representavam os interesses religiosos, com fortes nomes como Anthony Garotinho, evangélico que despontou com práticas sociais no Rio de Janeiro, em 1989, onde foi governador, em 1999, e candidato à presidência da República, em 2002, fato que pode ter influenciado diretamente no voto e predileção dos religiosos a candidatos que os representassem, demonstrando o estreitamento da religião e da política no Brasil.
Números s-perfeitos ímpares
Authors: Fernandes Hiller Alves
Published: March 2023

A teoria dos números é um campo da matemática que possui diversos problemas em aberto. Um número natural N é dito S-perfeito se a soma de todos os seus divisores positivos for igual a SN, isto é, em notação matemática σ(N)=SN. Um problema muito antigo é o da existência de números perfeitos ímpares. De modo geral, se sabe pouco sobre números S-perfeitos ímpares. Então, o intuito deste artigo é demonstrar e investigar certas propriedades sobre os números S-perfeitos ímpares, em especial, com S ímpar. Inicialmente, será realizada uma breve introdução sobre o tema. Em seguida, há 4 lemas que visam dar suporte e entendimento ao leitor para demonstrações posteriores. Logo após, será apresentado um teorema que é a pedra angular do artigo. Por fim, tem-se duas consequências em forma de corolários e uma breve conclusão da discussão.
ОРГАНІЗАЦІЙНА КУЛЬТУРА В СИСТЕМІ ЛІДЕРСТВА УНІВЕРСИТЕТУ
Authors: Каленюк Ірина , Цимбал Людмила
Published: March 2023

В статті розглядається сутність та форми прояву організаційної культури університету. Доведено важливість забезпечення університетської автономії для формування організаційної культури. Проаналізовано взаємозв’язок між організаційною культурою та досягненням лідерства університетами.
The Earth’s natural carbon cycle – Carbon reservoir ocean: How the sea absorbs carbon dioxide
Authors:   CDRmare
Published: March 2023

In the past decades, the world ocean has absorbed around 25 percent of the carbon dioxide emissions caused by humans, thus significantly slowing down climate change. Mankind could boost this natural climate service of the ocean by increasing its carbon uptake in a variety of ways.
RECENT ADVANCES IN COMPUTED TOMOGRAPHY RADIATION DOSIMETRY
Authors: Sarhan Hatan Ghazi , Noor Noramaliza Mohd  Noor , Mohamed Saini Suraini , Bahari Norafida
Published: March 2023

Computer tomography (CT) has proved fundamental in image evaluation throughout the past three decades. By combining rapid scanning with high-quality data sets, multi-detector technology continues to influence practice patterns. This has led to new applications and improved use in conventional applications. However, the increased use of CT has generated significant concern regarding the high radiation doses received by patients during CT scans compared to traditional radiography examinations. Many studies have been undertaken on minimizing patient dose and adhering to the as low as reasonably achievable (ALARA) principle. A total of 40 English articles from PubMed, Science Direct and Google Scholar were systematically summarized in this review paper to introduce the growth of CT scan from single-slice to multi-slice technology from 2000 until December 2020 as well as dual-energy and multi-detector CT technologies. The important role of utilizing CT radiation dosimeters for CT dose measurement is defined included CT dose reduction techniques.
Breaking down microbial hierarchies
Authors: Sulheim Snorre , Mitri Sara
Published: March 2023

Microbial communities that degrade natural polysaccharides are thought to have a hierarchical organization and one-way positive interactions from higher to lower trophic levels. Daniels et al. have recently shown that reciprocal interactions between trophic levels can occur and that these interactions change over the duration of a batch culture.
Rancang Bangun Sistem Informasi Wedding Archive Management pada KUA Sukadiri Tangerang
Authors: Maulani Giandari , Hia Era Era , Annisa Ufairotul
Published: March 2023

The Wedding Archive Management Information System at the KUA Sukadiri Tangerang is currently very much needed so that in managing the archiving of wedding document data for Sukadiri residents it can be more organized and easy to find. Previous problems occurred when filing arrangements related to Wedding Archive Management were not properly regulated, causing problems in the form of slow search of the required wedding document data until the data was scattered. The purpose of this study is to design and build a Wedding Archive Management information system for KUA Sukadiri Tangerang so that the arrangements for archiving marriage document data are well organized. This study applies data collection methods, PIECES system analysis methods, system design methods with UML diagrams, Visual paradigm, Black Box Testing, Laravel Framework and PHP programming language. The results of the research are in the form of a Web-based Wedding Archive Management Information System that can search wedding document data in a short time and has been implemented at KUA Sukadiri Tangerang.
Media Video Company Profile Sebagai Sarana Informasi Dan Promosi Pada PT Putra Karya Jasa Usaha
Authors: Sunarya Lusyani , Febrianto Mochammad , Salsabil Qathrunnada
Published: March 2023

Video media is the most important part for entrepreneurs, one of which is video media that can describe a company's identity, such as a company profile. This video simultaneously provides information and promotions to the market the company wants. One company that requires a company profile is PT. Putra Karya Jasa Usaha, namely an autobus company with a head office named Putra KJU, which is headquartered in the Commercial Lot, Jl. Citra Raya Boulevard No. 4, Tangerang Regency. The problem is, previously the media only used social media and print media, the concept of which was very simple. Since the 2020 pandemic, there has been a decrease in relations by 18.8% and the number of passengers has decreased by 61.6%. In contrast, the company had 16 associations in the previous year, as well as 751,463 passengers in a year. This motivated Putra KJU to make a company profile video as a promotional and information medium to provide an overview of the profile and services they offer to prospective passengers or clients. The method for making a company profile video is data collection, media design, and the Media Production Concept (KPM). Through this company profile video, Putra KJU can introduce corporate identity and help with marketing so that it is better known to many people.
Pembuatan Aplikasi Toko Thriftsans Berbasis Web Menggunakan PHP Dan MySQL
Authors: Handayani Indah Tri , Hati Kusuma , Pratama Muhammad Rio
Published: March 2023

Thriftsans is a clothing store that offers a wide variety of clothing styles. Thriftsans stores have customers ranging from the middle class to the upper class, with an average of thirty customer visits per day. Currently the sales system used is still manual, causing obstacles for the company including manual sales reporting, lack of marketing reach around the thriftsans store area, customers having difficulty getting the latest product information and lack of opportunity to get new customers, this has an impact on the company's revenue which not increasing. Therefore a website was created that can provide convenience in selling clothing products using the programming language PHP and MySQL as the database. This website only contains clothing products sold by Thriftsans, product installation history and payment confirmation using the transfer method. This website can be accessed at www.thriftsans.thriftsans.xyz. This application can be run on a browser and can make it easier for business owners to market clothing products at Thriftsans stores and can make it easier for customers to purchase products because it can save time and make it easier for customers without having to come to the store in person, of course it is very helpful for customers who are busy working and during a pandemic like today.

Keywords—Website, Ordering, PHP, MYSQL, Thriftsans

 

Thriftsans adalah toko pakaian yang menawarkan berbagai macam gaya pakaian. Toko Thriftsans memiliki pelanggan mulai dari kelas menengah hingga kelas atas, dengan rata-rata tiga puluh kunjungan pelanggan per hari. Saat ini sistem penjualan yang digunakan masih manual sehingga menimbulkan kendala bagi perusahaan antara lain pelaporan penjualan secara manual, kurangnya jangkauan pemasaran di sekitar area toko thriftsans, pelanggan kesulitan mendapatkan informasi produk terbaru dan kurangnya kesempatan untuk mendapatkan pelanggan baru,  hal ini berdampak pada pendapatan perusahaan yang tidak meningkat. Maka dari itu dibuatlah website yang dapat memberikan kemudahan dalam menjual produk pakaian dengan menggunakan bahasa pemrograman PHP dan MySQL sebagai databasenya. Website ini hanya berisi produk pakaian yang dijual oleh Thriftsans, riwayat pemasangan produk dan konfirmasi pembayaran menggunakan metode transfer. Website ini dapat diakses di www.thriftsans.thriftsans.xyz. Aplikasi ini dapat dijalankan pada browser dan dapat mempermudah pemilik usaha dalam memasarkan produk pakaian pada toko Thriftsans serta dapat mempermudah pelanggan dalam melakukan pembelian produk karena dapat menghemat waktu dan mempermudah pelanggan tanpa harus datang ke toko secara langsung, tentunya sangat membantu bagi pelanggan yang sibuk bekerja dan pada masa pandemi seperti saat ini.

Kata Kunci—Website, Pemesanan, PHP, MySQL, Thriftsans
Model Sistem Informasi Eksekutif Sebagai Pendukung Keputusan di RSUD Dr. Moewardi
Authors: Gunawan Gugun , Henderi Henderi , Azizah Nur
Published: March 2023

Rumah sakit mempunyai tujuan agar tercapai pelayanan Kesehatan yang optimal pada pasien secara cepat dan tepat serta terpadu dalam penanganan penyakit yang diderita oleh pasien. Beragamnya jenis penyakit dan kondisi pasien, serta banyaknya kunjungan yang datangbersamaan ke rumah sakit telah mengakibatkan kepadatan di wilayah rumah sakit. Kepadatan ini ketika permintaan untuk layanan melebihi kapasitas dari perawat, ruangan, pengetahuan serta pengobatan untuk memberikan perawatan yang berkualitas dalam kerangka waktu yang tepat maka pelayanan harus cepat. Tujuan dari penelitian ini adalah untuk mengetahui hubungan respontime pelayanan dengan sistem pendukung keputusan di RSUD Dr. Moewardi dengan membuat suatu model sistem informasi eksekutif sebagai pendukung keputusan.
Perancangan Sistem Informasi Geografis Badan Usaha di LPJK Provinsi Banten
Authors: Nuryani Ely , Budiman Ramdani , Fernando Iqbal
Published: March 2023

LPJK Provinsi Banten merupakan organisasi yang mengimplementasikan peranmasyarakat jasa konstruksi dalam melaksanakan pengembangan jasa konstruksi. Prosespengembangan layanan jasa konstruksi di LPJK Provinsi Banten banyak dilakukan olehperusahaan konstruksi di seluruh Indonesia. Banyaknya perusahaan jasa konstruksi yangtersebar di berbagai daerah di Propinsi Banten harus diketahui dan mudah ditemukan.Permasalahan yang terjadi saat ini adalah sulitnya membuat pemetaan data Perusahaan JasaKonstruksi. Pemetaan tersebut meliputi data perusahaan jasa konstruksi, aset yang dimiliki danlokasi atau tempat dimana perusahaan jasa konstruksi beroperasi. Untuk mengatasipermasalahan tersebut dibangunlah sistem informasi geografis Perusahaan Jasa Konstruksi.Agar dapat diakses secara online, sistem ini dibangun pada sistem berbasis web dengan menggunakan bahasa pemrograman PHP dan My SQL sebagai databasenya. Pemodelan sistem yang digunakan dalam pembangunan sistem ini adalah Data Flow Diagram (DAD). Metodeyang digunakan dalam mengembangkan sistem ini adalah metode waterfall. Sistem yang dibangun menyediakan fasilitas pencarian identitas atau profil perusahaan dan lokasinya pada sistem. Dengan adanya sistem informasi geografis ini dapat membantu pihak pemerintah maupun swasta yang membutuhkan jasa konstruksi untuk mencari, menemukan dan melihat identitas perusahaan jasa konstruksi dengan mudah.
Penerapan Algoritma K-Nearest Neighbor Untuk Prediksi Mahasiswa Berpotensi Dropout
Authors: Nurwati Nurwati , Azizah Nur , Santoso Yudi
Published: March 2023

Peramalan atau prediksi mahasiswa berpotensi dropout digunakan untuk memonitor jumlah mahasiswa aktif agar perkuliahan lancar dan lulus tepat waktu. Prediksi menggunakan algoritma K-NN digunakan karena salah satu kelebihannya yaitu tangguh terhadap training data yang noise dan efektifapabila data latih nya besar. Setelah didapat hasil dari proses K-NN lalu dilakukan pengujian menggunakan confusionmatrix menghasilkan nilai akurasi 0,83. Nilai presisi 1 dan nilai recall 0,78.
Psychology of home and Ukrainian migrants’ socio-psychological adaptation abroad
Authors: Korobanova Olha , Schulzhenko Neonila
Published: March 2023

Study goal and methods. Study of the course of socio-psychological adaptation of Ukrainian refugees abroad, their perceptions of home and host country, as well as intergroup interaction between Ukrainian refugees and the autochthonous population. The research was conducted within the framework of the scientific approach to intergroup interaction as the dynamics of conscious and unconscious. Case study of narratives of Ukrainian migrants as a form of representation of individual meanings and thematic construction of experience was conducted. Conclusions. A structured life world that integrates the experience associated with the evacuation of refugees from Ukraine and the new stage of life abroad, based on the construction of personal experience into meaningful event blocks, is a prerequisite for successful socio-psychological adaptation and acculturation in the host country. During integration into the host society migrants learn new relevant communicative and social roles. Group support provided to refugees by other Ukrainians in a similar situation as well as by representatives of the host country and volunteers is of great importance. The limitations of the study are related to the situational nature of narrative interviews, the variability of events and meanings that are significant for the individual at the moment. Prospects for further research include the study of age-specific features of socio-psychological adaptation abroad and the temporal dynamics of this process. Practical Importance. Data from the original descriptive study of the socio-psychological processes of acculturation indicate the importance of group support and experience construction in overcoming stress and can be used in the provision of psychosocial support to Ukrainian military migrants
Sabina and Me: How Thinking About Sabina Spielrein Accompanied Me Through The Early Pandemic
Authors: Sinsheimer Kathy
Published: March 2023

In 2020, the Covid-19 pandemic ushered in novel life circumstances of destruction and chaos. Couples and families struggled with isolation, fear, lack of human contact, and absence of resources, such as school and church. In 1911, Sabina Spielrein, an early psychoanalyst, wrote the paper "Death as the cause of becoming" in which she argued that creativity arises from the destruction of previously viable entities coming together in a newly formed creation. During this period of pandemic quarantine, the author, a couple and family therapist, turned to Sabina Spielrein, colleagues, nature, and writing to think about the isolation, fear, and destruction confronting her, her patients, and the world at large. In this process, the author found theory, memory, and fellow travellers to join her in the use of these ideas to confront the challenges of life during the pandemic.
Family and the Turbulent World
Authors: Levisky Ruth Blay
Published: March 2023

This article proposes an elaboration and extension of link psychoanalysis, via the concept of the link complex. It considers the impacts on the mind in the face of the contemporary world, including the diversity of linking configurations, the Covid-19 pandemic, and the different resources that have to be created to assure continuity of clinical care during the pandemic. It considers the impacts upon the analyst's mind in response to these strains, and proposes the link complex as a means of conceptualising how current realities alter the definition of what the contemporary family is.
Significance of breeding value indicators for prediction of milk yield
Authors: Shablia V. , Chaliy O. , Danilova T. , Zadorozhna I. , Krygina N.
Published: March 2023

A comparative assessment of the significance of various indicators of the breeding value of breeding bulls for predicting milk yield in the highly productive herd of the farm economy "Alfa" was carried out. The milk yield of cows, whose bulls-fathers were evaluated in Ukraine and abroad, was studied. It was established that in the period from 2009 to 2014, the milk yield of first-calf heifers increased by 23.9 % and reached 5894.3 kg. Accordingly, during the specified period, most of the quantitative indicators of the breeding value and milk productivity of the bulls' daughters also increased: the breeding value of the parent bulls in terms of milk yield increased from +245.3 kg in 2009 to +540.4 kg in 2014; the breeding value of parent bulls in terms of the total amount of milk fat per lactation increased from +10.2 kg to +29.7 kg. A correlation analysis of the relationships between various indicators of breeding value of parent bulls and the milk yield of their daughters was carried out. It was established that the actual milk yield of first-calf heifers in FE "Alfa" most (correlation coefficients r higher than 0.8) and most significantly (p<0.001) depended on the average milk yield and amount of milk fat yield of bull's daughters in the herds where the breeding value of these bulls was evaluated. The breeding value of the sire bulls by the amount of milk fat yield was also characterized by high (r=0.675) and significant (p<0.01) relationship with the actual milk yield of the first-calf heifers (daughters of these sires). The variance analysis of the influence of the breeding value estimation method of breeder bulls (BV, ETA, ZW, DRV, RPC) on the actual milk yield of their daughters during the first lactation established that this influence was significant (p=0.001), and the power of influence was η2=0,59. Significant differences were mostly observed between milk yields of first-calf heifers whose parent bulls were evaluated abroad and in Ukraine. The biggest difference in terms of actual milk yield was revealed between the daughters of bulls evaluated by the ETA method (Canada) and by the "daughter-of-the-same-age (DRV)" method (Ukraine). This difference was 2640 kg of milk (p<0.01) in favor of firstcalf heifers from Canadian bulls.

Key words: breeding bulls, breeding value, milk productivity, daughters of bulls, milk yield, selection index, evaluation method.
Application of mineral carriers for immobilization of Trichoderma viride
Authors: Mitiohlo L. , Merzlov S. , Merzlova H. , Osipenko I.
Published: March 2023

There is no doubt in the fact that preparations containing Trichoderma as the main component are currently a real alternative to synthetic agrochemicals as antagonists of soil-borne plant diseases and growth stimulators. The use of this kind of drugs does not always give sufficiently stable results. In addition, technological problems can often arise, which are associated with the short shelf life of liquid preparations based on Trichoderma. The use of the solid form of the drug often causes the problem of self-inhibition of conidia germination. And therefore a more careful calculation of the optimal dose for each specific strain is required. The development of multifunctional bio-preparations that are more stable in their effectiveness, especially preparations that include Trichoderma, is one of the most important tasks in the system of biotechnology development, which determined the relevance of the research. The aim of the work is to establish the optimal carrier for the immobilization of Trichoderma viride cells and the effect of immobilization on the stability of drugs. It has been experimentally established that the growth and development of the immobilized fungus Trichoderma viride is influenced by the nature and method of modification of the carrier. It was established that when the fungus immobilized on native and modified carriers (particle size 0.5 μm – 2.5 mm) was seeded on a sterile nutrient medium, a decrease in the growth rate of Trichoderma viride was found, compared to the control one where the native fungus was used. It has been proven that the optimal amount of grinding of both native and modified media is – 150 μm – 1.5 mm. It has been found that saponite modified with starch is the optimal carrier for Trichoderma viride immobilization. It has been proven that upon immobilization of the fungus Trichoderma viride, the latter becomes more resistant to the negative factors of the growth environment (antagonistic action of the natural conglomerate of microorganisms residing on spoiled alfalfa hay).
Key words: fungi, cell immobilization, carriers, modified starch, humic acids, saponite, zeolite, zeolite-containing basalt tuff.
Effect of cerium dioxide nanoparticles on metabolic processes in the body of broiler chickens
Authors: Tsekhmistrenko O. , Bityutskyy V. , Tsekhmistrenko S. , Demchenko O. , Spivak M.
Published: March 2023

The scope of application of cerium dioxide and its special physical and chemical properties are considered in the work. The effect of the size factor on the properties of nanodispersed cerium dioxide determines the biological activity of the material, low toxicity and high oxygen non-stoichiometry. Specific properties of CeO2 include the ability to regenerate oxygen non-stoichiometry, which is expressed in the ability of cerium dioxide nanoparticles to return to their initial state after participating in the redox process in a relatively short period of time, which enables their repeated use. Nanoparticles, due to their small size, easily penetrate into the body through the respiratory, digestive, and skin organs and exhibit more pronounced biological activity due to the large surface area per unit mass. The change in the physical and chemical mechanisms of action of nanoparticles is due to the fact that most of the atoms are on the surface. Such an arrangement changes the physical, chemical, biological, toxicological properties of the substance and facilitates the interaction of nanoparticles with a living organism. Once inside a biological system, nanoparticles come into contact with a number of physical and chemical features of the organism, which affect their properties and can change the response. These features are largely due to the ability to pass through the redox cycle between two natural oxidation states (Ce3+ and Ce4+). The influence of cerium dioxide nanoparticles on metabolic processes in the body of broiler chickens has been established. Their introduction contributed to an increase in the content of total lipids in the blood by 24.6–31.3 %, albumins – by 16–22 %, and a decrease in the content of uric acid to the level of 63–67 % of the control. Non-toxicity of poultry meat treated with nano-cerium for consumers was established. The high degree of biocompatibility, low toxicity and catalytic activity of nanodispersed cerium dioxide make it possible to consider it as a promising nanobiomaterial for use in biology, medicine and agriculture.

Key words: nanobiotechnologies, nanoparticles, ceriumdioxide, layinghens, lipids.
Clinical practice guidelines and real-life practice in hepatocellular carcinoma: A Japanese perspective
Authors: Koga Hironori , Iwamoto Hideki , Suzuki Hiroyuki , Shimose Shigeo , Nakano Masahito , Kawaguchi Takumi
Published: March 2023

Striking advances in systemic therapy for unresectable advanced hepatocellular carcinoma (HCC) have improved the average prognosis of patients with HCC. As a result, the guidelines for the treatment of HCC have changed significantly. However, various issues have emerged in clinical practice. First, there is no established biomarker that can predict response to systemic therapy. Second, there is no established treatment regimen after primary systemic therapy, including combined immunotherapy. Third, there is no established treatment regimen for intermediate-stage HCC. These points make the current guidelines ambiguous. In this review, we present the Japanese guidelines for the diagnosis and treatment of HCC based on the latest evidence; introduce various efforts mainly in Japanese real-life practice to update these guidelines; and present our perspectives on future guidelines.
Post caesarian section surgical site infections. Review of current literature
Authors: Ziogou Afroditi , Kokolakis Ioannis
Published: March 2023

Caesarean delivery rates have increased globally during the past three decades. Caesarean delivery is the most important obstetrical procedure performed with complications that consist of postpartum hemorrhage, endometritis, thromboembolic events or incision infections. While surgical site infections (SSIs) complicate 1.9% of all surgeries performed, the incidence of SSIs after caesarean delivery is significantly higher, almost 7-10%, constituting an important cause of increased morbidity, mortality, readmission, prolonged hospitalization and increased health care costs worldwide. Incisional infection after caesarean delivery happens in 2-7% of cases, necrotizing fasciitis in 0.18% and endometritis in 2-16%. Many risk factors for SSIs have been described. This review includes the several risk factors that have been identified in women who developed post-caesarean section surgical site infections. We also provide an overview of strategies for prevention of postoperative infections including antibiotic prophylaxis, surgical techniques, management of wound infections. Criteria of diagnosis for SSIs are also given, as well as current treatment regimens. Given the impact of maternal post-caesarean infection, it is important for gynecologists to understand how to prevent these postoperative infections, as well as recognize and treat them.
Euglycaemic ketoacidosis during pregnancy: More common than you think
Authors: Sapantzoglou I. , Psarris A. , Perros P. , Varthaliti A. , Antsaklis P. , Theodora M. , Syndos M. , Daskalakis G.
Published: March 2023

Background: Euglycaemic ketoacidosis is a rare type of metabolic acidosis, with increased production of ketonic bodies and normal serum glucose. When it occurs during pregnancy, it might lead to adverse maternal and fetal outcomes. Pregnancy itself is a diabetogenic state that might predispose the patient to develop ketoacidosis following even relatively short periods of starvation and as such, a high index of suspicion is required for the diagnosis to be made and for the management plan to be established. Case presentation: We present a case of euglycaemic ketoacidosis in a twin pregnancy, which occurred in the second trimester, necessitating prompt and aggressive management, that eventually required early delivery due to the development of preeclampsia. Discussion/Conclusion: The physiology and pathology of euglycaemic ketoacidosis during pregnancy and the management required to avoid the potential maternal and fetal risks that such a condition might be complicated with.
Rereading Paul B. Preciado’s An Apartment on Uranus through Latin American Decolonial Transfeminism(s)
Authors: Michalak M.
Published: March 2023

What can be learnt from Paul B. Preciado’s ecological framing of trans* and migrant world-making in An Apartment on Uranus? How might trans* and migrant solidarities affirm life in the context of capitogenic climate catastrophe and what Françoise Vergès has named the ‘racial capitalocene’? Through these guiding questions, I connect recent calls to ‘decolonize trans* imaginaries’ with translocal hispanophone knowledges that reaffirm the plurality of gender/sexuality in las Amé ricas before the conquest by braiding together strands of Preciado’s writing with Latin American decolonial transfeminists such as María Lugones and Gloria Anzaldúa, among others. Reviewing recent debates on how ‘border imperialism’ unevenly shapes and restricts trans* and migrant mobility, I address criticisms of Preciado’s analogies between trans* and migrant experiences, by considering how his writings on these themes offer an intersectional reflection on the multiple cracks of the nation-state, the fictions of race and regimes of binary gender to reveal the cracks of capitalism.
Faecalibacterium prausnitzii Improves Lipid Metabolism Disorder and Insulin Resistance in Type 2 Diabetic Mice
Authors: Xuan Wenting , Ou Yijing , Chen Wenting , Huang Lishan , Wen Chuangyu , Huang Guangying , Tang Wenting , Zeng Daidi , Huang Suran , Xiao Lijuan , Li Zhongjun
Published: March 2023

Purpose: Additional effective therapeutic strategies for Type 2 diabetes (T2D) patients are urgently needed. Gut microbiota plays an important role in T2D development and is a promising treatment strategy for T2D patients. Faecalibacterium prausnitzii (F. prausnitzii) is regarded as one of the most important bacterial indicators for a healthy gut, but the mechanisms of its anti-diabetic properties are still unclear.

Methods and Results: The abundance of F. prausnitzii in feces of patients with T2D was detected by using qPCR. The effects of F. prausnitzii on glucose homeostasis, insulin resistance (IR), dyslipidemia, hepatic steatosis and inflammation were investigated in type 2 diabetic (T2D) db/db mice. We also investigated F. prausnitzii in people. Our results showed that the abundance of F. prausnitzii was significantly lower in T2D patients compared to healthy subjects. In T2D mice, we found that F. prausnitzii treatment significantly decreased fasting blood glucose and IR index, indicating improved glucose intolerance as well as IR. Furthermore, based on evaluation of lipid-regulating enzyme activities and proinflammatory cytokine levels, F. prausnitzii was not only able to improve inflammation in both adipose tissue and liver, but also ameliorate hepatic steatosis through inhibiting the activity of hepatic lipogenic enzymes.

Conclusion: These results suggested that F. prausnitzii might serve as a therapeutic option for T2D by improved IR, lipid metabolism and inflammation.
CCAT 1- A Pivotal Oncogenic Long Non-Coding RNA in Colorectal Cancer
Authors: Liau Xiew Leng , Salvamani Shamala , Gunasekaran Baskaran , Chellappan Dinesh Kumar , Rhodes Anthony , Ulaganathan Vaidehi , Tiong Yee Lian
Published: March 2023

Colorectal cancer (CRC) is ranked as the third most common cancer and second deadliest cancer in both men and women in the world. Currently, the cure rate and 5-year survival rate of CRC patients remain relatively low. Therefore, discovering a novel molecular biomarker that can be used to improve CRC screening, diagnosis, prognosis, and treatment would be beneficial. Long non-coding RNA colon cancer-associated transcript 1 (CCAT 1) has been found overexpressed in CRC and is associated with CRC tumorigenesis and treatment outcome. CCAT 1 has a high degree of specificity and sensitivity, it is readily detected in CRC tissues and is significantly overexpressed in both premalignant and malignant CRC tissues. Besides, CCAT 1 is associated with clinical manifestation and advanced features of CRC, such as lymph node metastasis, high tumor node metastasis stage, differentiation, invasion, and distant metastasis. In addition, they can upregulate oncogenic c-MYC and negatively modulate microRNAs via different mechanisms of action. Furthermore, dysregulated CCAT 1 also enhances the chemoresistance in CRC cells while downregulation of them reverses the malignant phenotypes of cancer cells. In brief, CCAT 1 serves as a potential screening, diagnostic and prognostic biomarker in CRC, it also serves as a potential therapeutic marker to treat CRC patients.
Rumen biogeographical regions and their impact on microbial and metabolome variation
Authors: Soltis Macey P. , Henniger Madison T. , Egert-McLean Amanda M. , Voy Brynn H. , Moorey Sarah E. , Schnieder Liesel G. , Shepherd Elizabeth A. , Christopher Courtney , Campagna Shawn R. , Smith Joe S. , Mulon Pierre-Yves , Anderson David E. , Myer Phillip R.
Published: March 2023

The rumen microbiome is a complex microbial network critical to the health and nutrition of its host, due to their inherent ability to convert low-quality feedstuffs into energy. In rumen microbiome studies, samples from the ventral sac are most often collected because of the ease of access and repeatability. However, anatomical musculature demarcates the rumen into five sacs (biogeographical regions), which may support distinct microbial communities. The distinction among the microbes may generate functional variation among the rumen microbiome, thus, specialized tasks within different sacs. The objective of this study was to determine the rumen liquid metabolome and epimural, planktonic, and fiber-adherent bacterial communities among each rumen biogeographical region. It was hypothesized that differences in bacterial species and metabolome would occur due to differing anatomy and physiology associated with the respective regions. To assess this variation, epithelial and content microbial-associated communities were evaluated, as well as the metabolites among various rumen biogeographical regions. A total of 17 cannulated Angus cows were utilized to examine the fiber-adherent (solid fraction), planktonic (liquid fraction), and epimural microbial communities from the cranial, dorsal, caudodorsal blind, caudoventral blind, and ventral sacs. Metagenomic DNA was extracted and sequenced from the hypervariable V4 region of the 16S rRNA gene. Reads were processed using packages ‘phyloseq’ and ‘dada2’ in R. Untargeted metabolomics were conducted on rumen liquid from each sac using UHPLC-HRMS and analyzed in MetaboAnalyst 5.0. An analysis of variance (ANOVA) revealed 13 significant differentially abundant metabolites with pairwise comparisons against the five rumen sacs (P < 0.05). Within the bacterial communities, neither alpha nor beta diversity determined significance against the rumen sacs (P > 0.05), although there was significance against the fraction types (P < 0.05). Utilizing multivariable association analysis with MaAslin2, there were significant differential abundances found in fraction type × location (P < 0.05). Knowledge of similarities among fiber-adherent microbial communities provides evidence that single sac sampling is sufficient for this fraction. However, future projects focusing on either planktonic or epimural fractions may need to consider multiple rumen sac sampling to obtain the most comprehensive analysis of the rumen. Defining these variabilities, especially among the rumen epimural microbiome, are critical to define host-microbiome interactions.
Gelatin-based anticancer drug delivery nanosystems: A mini review
Authors: Jiang Xianchao , Du Zhen , Zhang Xinran , Zaman Fakhar , Song Zihao , Guan Yuepeng , Yu Tengfei , Huang Yaqin
Published: March 2023

Drug delivery nanosystems (DDnS) is widely developed recently. Gelatin is a high-potential biomaterial originated from natural resources for anticancer DDnS, which can effectively improve the utilization of anticancer drugs and reduce side effects. The hydrophilic, amphoteric behavior and sol-gel transition of gelatin can be used to fulfill various requirements of anticancer DDnS. Additionally, the high number of multifunctional groups on the surface of gelatin provides the possibility of crosslinking and further modifications. In this review, we focus on the properties of gelatin and briefly elaborate the correlation between the properties and anticancer DDnS. Furthermore, we discuss the applications of gelatin-based DDnS in various cancer treatments. Overall, we have summarized the excellent properties of gelatin and correlated with DDnS to provide a manual for the design of gelatin-based materials for DDnS.
Extracellular vesicles: A dive into their role in the tumor microenvironment and cancer progression
Authors: Lopez Kassandra , Lai Seigmund Wai Tsuen , Lopez Gonzalez Edwin De Jesus , Dávila Raúl G. , Shuck Sarah C.
Published: March 2023

Extracellular vesicles (EVs) encompass a diverse set of membrane-derived particles released from cells and are found in numerous biological matrices and the extracellular space. Specific classes of EVs include apoptotic bodies, exosomes, and microvesicles, which vary in their size, origin, membrane protein expression, and interior cargo. EVs provide a mechanism for shuttling cargo between cells, which can influence cell physiology by transporting proteins, DNA, and RNA. EVs are an abundant component of the tumor microenvironment (TME) and are proposed to drive tumor growth and progression by communicating between fibroblasts, macrophages, and tumor cells in the TME. The cargo, source, and type of EV influences the pro- or anti-tumoral role of these molecules. Therefore, robust EV isolation and characterization techniques are required to ensure accurate elucidation of their association with disease. Here, we summarize different EV subclasses, methods for EV isolation and characterization, and a selection of current clinical trials studying EVs. We also review key studies exploring the role and impact of EVs in the TME, including how EVs mediate intercellular communication, drive cancer progression, and remodel the TME.