bluuebunny/crossref_metadata_2025 huggingface dataset:
Fear of receiving less effective care: A barrier to effective cancer care cost communication.
Authors: Kang Sokbom , Yu Ye Lee
Published: October 2019

8

Background: Increasing financial burden in cancer care promoted cost communication as an intervention to the problem. We explored patients’ attitudes and concerns for the physician-patient communication of the costs of cancer care. Methods: From an oncology outpatient clinic, patients were recruited and interviewed using a 29-item questionnaire. The questionnaire includes basic and financial characteristics, attitudes toward cost-communication, and experience of cost-communication with oncologists. Results: Among 292 patients with gynecologic cancer, 68% were found to have an income below the nation’s average households income. Although the majority (81%) of patients have a positive attitude toward patient-physician cancer care cost-communication, however, only 19% of them wanted to discuss the cost with their physicians - 33% of them did not want to disclose their financial status to health care providers and 48% wanted to discuss the cost with other providers than their physicians. In addition, while 87% preferred to be informed about costs for various treatment options, 86% of them did not want to receive cost-effective treatment and preferred to receive the most effective treatment regardless of their financial status. Compared with non-cancer patients (n = 83), significantly more patients had a negative attitude to disclosing their financial status especially to their physician (22% vs. 11%, P = 0.024). Conclusions: A considerable proportion of cancer patients had concerns that cost communication with their physician may interfere with their opportunity to access the best care options. To facilitate cost communication, oncologists should understand such concerns and making a thoughtful effort to relieve the concern during cost communication.
Clinical study of gefitinib maintenance therapy after concurrent radiotherapy and chemotherapy for locally advanced NSCLC with EGFR sensitive mutations.
Authors: Xin Ying
Published: October 2019

87

Background: To investigate the value of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in the maintenance therapy of locally advanced NSCLC after concurrent radiotherapy and chemotherapy. Methods: From Jan 2010 to Jan 2015, 166 patients with locally advanced NSCLC were treated in JCH. Total 86 patients with no progress after concurrent radiotherapy and chemotherapy were selected. Within 2 to 6 weeks after therapy, eligible patients received TKI (Gefitinib 250mg/day) or were observed for 1 year. If disease progresses or intolerable adverse reactions occur, the treatment should be discontinued. Chest and abdomen CT exam were performed 2 weeks before TKI treatment, and every 2 months thereafter. The same assessment techniques were used throughout the study. Therapeutic evaluation refers to the RECIST. SPSS 19.0 was used for data analysis and processing. Survival analysis was performed by Kaplan-Meier method. Results: In TKI drug group, CR 6 cases, PR 18 cases, SD 12 cases, PD 7 cases; in observation group, CR 3 cases, PR 11 cases, SD 13 cases, PD 16 cases. The CR + PR were 54.5% and 31.8% respectively, P = 0.031. The CR + PR + SD were 81.8% and 61.4% respectively, P = 0.033. The objective remission rate and disease control rate of TKI group were higher than those of observation group. The TTP in TKI group was 13.6 months (CI: 12.88-14.32 months) and that in observation group was 10.8 months (CI: 9.87-11.73 months), P = 0.001. The median OS of TKI group was 34.5 months (CI: 32.12-36.88 months) and that of observation group was 30.3 months (CI: 28.64-31.96 months), P = 0.029. Conclusions: 1. The objective remission rate and disease control rate of TKI group were higher than those of placebo group. 2. Ohitinib was not on the market in China at the time of this study and economic reason, so palliative chemotherapy was the main way to treat condition, and no third-generation TKI drugs were used. This may be one of the reasons why the total OS in this study was not long. 3. TKI drugs can improve the disease control rate and prolong the survival time of patients with locally advanced NSCLC after concurrent radiotherapy and chemotherapy, and have less side effects.
Preliminary results of endoscopic submucosal dissection in Vietnamese patients with gastric pre-neoplasia lesion.
Authors: Duc Canh Tran , Tuyet Bui Anh , Dat Pham Quoc , Chu Nguyen Van
Published: October 2019

91

Background: Gastric cancer is in the top three most common cancers in Vietnam and the disease is mainly detected in late stage. There is a lack of evaluation of the pre-neoplasia stage of gastric cancer and selection an appropriate and effective treatment remains still in debate. Hence, the study aims to evaluate, for the first time, the safety and efficacy of the application of endoscopic submucosal dissection (ESD) technique on Vietnamese patients with pre-neoplasia lesion in stomach. Methods: We included all patients diagnosed with lower or high-grade gastric dysplasia and hopitalized in the Department of Endoscopic and Functional Exploration in K Hospital from March 2018 to June 2019. Eligible patients were applied by the ESD technique as the standard treatment. We evaluated the efficacy and safety of after the intervention of ESD by the neoplasia recurrence rate after 3 months and the occurrence of adverse events during and after the ESD procedure described in frequency and percentage. Results: During the investigational period, we chose 65 pre-neoplasia gastric patients for the application of ESD technique. The male/female ratio was 1.09 and the mean age of patients was 58.07 years. The duration of hospitalization was about 3 days. We found 57 patients (87.69%) with location of the lesions in pylorus. The average of tumor sizes was 20.46 mm. All patients were treated with curative en bloc resection and no case was found as failure. Out of 65 patients, we found 2 patients (3%) with bleeding complication, no perforation and other post-surgery complication were identified. The average of procedure time was short (67.53 minutes). The histopathological specimen results revealed that 20 patients (30.76%) were diagnosed as cancer and 40 patients (61.53%) were diagnosed as high-grade dysplasia, all patients had a margin negative after ESD. After 3 months of treatment, all patients have no pre-neoplastic recurrence. Conclusions: Our result showed that the ESD technique is relatively safe and effective for Vietnamese patients with pre-neoplasia at stomach.
Consolidation chemoradiation improves survival in responders to first-line chemotherapy (CT) in locally advanced GBC (LA-GBC).
Authors: Agrawal Sushma , Alam Md Nawed , Rastogi Neeraj , Das KJ Maria
Published: October 2019

97

Background: CT is the standard of care in advanced GBC [LA-GBC and metastatic GBC (M-GBC)]. The survival rates with CT are better in LA-GBC than M-GBC. Should responders to CT with good performance status (PS) be offered consolidation chemo-radiation (cCTRT) to delay progression and improve survival? There is scarcity of literature on this approach in the literature. We present our experience with this approach in LA-GBC which presents in endemic proportions in this region. Methods: We reviewed the records of consecutive GBC patients over 3 year period (2014-2016) after ethics approval. Out of 550 patients, 145 were LA-GBC who were treated with radical intent. Patients with good PS and responders to CT (partial and stable disease) but unresectable, were treated with cCTRT. Radiotherapy was given to GB bed, peri-portal, common hepatic, coeliac, superior mesentric and para aortic lymph-nodes (upto L2 vertebra) upto a dose of 45-54 Gy in 25 to 28 fractions along with concurrent capecitabine @ 1250 mg/m2. Response to treatment was categorised according to RECIST criteria based on CECT abdomen. Treatment toxicity, OS and factors affecting OS were computed by Cox-Regression analysis. Results: Burden of disease was [T3 (55%), T4 (45%), N1 (30%), N2 (70%)]. 65% patients underwent CT alone and 35% received CT followed by cCTRT. 10 patients underwent Radical Surgery ( 6 after CT and 3 after cCTRT). The incidence of grade 2 toxicity were: gastritis (10%) and diarrhoea (5%). 65% patients achieved partial response (PR), 12% static disease (SD), 10% progressive disease (PD) and 13% were non-evaluable (NE) [ did not complete 6 cycles CT or lost to follow-up]. At a median follow-up of 8 months (IQR 5-15 months), the median OS was 9 months for all, 7 months with CT and 14 months with cCTRT arm (p=0.04).The median OS was 57 months for CR, 12 months for PR and SD, 7 months for PD and 5 months for NE (p=0.008). OS was 10 months for KPS >80 and 5 months for KPS <80 (p=0.008). Type of treatment and response to treatment were retained as independent prognostic factors affecting OS. Conclusions: CT followed by cCTRT doubles survival in responders with good PS. This innovative approach should be tested in a randomised study.
Systematic Approach to Selecting and Preparing a Medical Power of Attorney in the Gynecologic Oncology Center
Authors: Zhukovsky Donna S. , Soliman Pamela T. , Mathew Boby , Mills Sarah , Bodurka Diane , Frumovitz Michael , Meyer Larissa A. , Westin Shannon , Nowitz Marisa , Archie LaShan , Fenton Shauna , Lang Kai , Williams Janet L. , Boving Valentine , Bruera Eduardo
Published: October 2019

PURPOSE:

Advance care planning (ACP) supports national priorities of patient engagement, person-centered care, and safety. A systematic approach is uncommon in most care settings. Our institution offers all patients with cancer new to the institution an opportunity to select and prepare a medical decision maker (MDM) after social work counseling. The goals of this study were to determine the success of a systematic institutional process for selecting a prepared MDM. The primary objectives were that (1) 70% or more of new patients would have one or more documented social work ACP discussions by the third office visit within 4 months, and (2) there would be a two-fold increase in scanned medical power of attorney (MPOA) documents available in the electronic health record (EHR). The secondary objectives were (1) improved surrogate preparedness for medical decision making, and (2) to determine whether patients with metastatic disease demonstrated greater readiness for selection of an MDM than those with localized disease.

MATERIALS AND METHODS:

We conducted a retrospective chart review of consecutive gynecology oncology outpatients.

RESULTS:

Of 133 patients, 93 (70%) had metastatic disease. The median number of visits was two (one to three). Forty-seven patients (39.3%) met with social work by visit 3. Review of ACP notes suggested that most patients were in the early stages of selecting a prepared MDM. At visit 1, 39 (29.3%) reported having an advance directive document; 14 (10.5%) had an MPOA in the EHR. There was no increase by visit 3. Fewer patients with metastatic disease than those with localized cancer (32.3% v 67.5%; P = .001) had three visits; no other parameter, including presence of MPOA documents in the EHR, achieved statistical significance between groups.

CONCLUSION:

Current processes fail to engage patients in selecting and preparing an MDM.
System of means of individualization of individuals as subjects of civil law
Authors: Лукашевич Светлана , Lukashevich Svetlana
Published: October 2019

In the monograph the complex scientific representation about system of means of individualization of subjects of civil law - physical persons is formulated. the place of Institute of civil-legal means of individualization of the physical person in system of civil law is Defined. The possibility of using methods of forensic identification in civil relations is considered. The necessity of such use and, as a consequence, the need for its legislative consolidation in the framework of civil, business and family law is substantiated. Legal definition of "individualization of physical persons" and "means of individualization", considered the possible classification of such assets and the problems of their application subjects of civil relations, and proposes the main ways to improve this tool.
Designed for legal scholars, as well as graduate students, students of educational institutions, practitioners in the field of law and public services. May be of interest to employees of legislative authorities and state bodies.
Fundamentals of municipal management organization
Authors: Наумов Сергей , Naumov Sergey , Ведяева Екатерина , Vedyaeva Ekaterina , Гребенникова Анна , Grebennikova Anna
Published: October 2019

The textbook reveals the main topics in the disciplines of the municipal block and is designed to form the level of training of students, defined by both state standards and additional requirements established by educational institutions.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
For students-bachelors of educational institutions of higher education and students of organizations of additional professional education, as well as for teachers, state and municipal employees, deputies and all interested in the formation and development of the system of state and municipal government in Russia.
The Use and Value of Social Information in Selective Selling of Exclusive Products
Authors: Momot Ruslan , Belavina Elena , Girotra Karan
Published: October 2019

We consider the use and value of social-network information in selectively selling goods and services whose value derives from exclusive ownership among network connections or friends. Our model accommodates customers who are heterogeneous in their number of friends (degree) and their proclivity for social comparisons (conspicuity). Firms with information on either (or both) of these characteristics can use it to make the product selectively available and to personalize prices. We find that firms’ preferred customers are low degree and high conspicuity, with the conspicuity threshold nondecreasing in degree. Interestingly, although both degree and conspicuity levels are relevant to curating the desired customer base, we find that firms do not need conspicuity information to do so; its absence can be substituted by incentivizing customers to self-select. There is no such recourse for the absence of degree information. As a result, degree information is typically more valuable than conspicuity information. Our analysis suggests that there are two canonical categories of social information—less valuable “consonant” information on characteristics where firm and customer preferences are aligned and more valuable “competing” information where preferences are misaligned. Customers can be incentivized to act in a way that their actions are a perfect substitute for consonant information, making it less valuable.

This paper was accepted by Gad Allon, operations management.
Research roundup: October 2019
Authors: Poole Patricia , Odd Dawn
Published: October 2019

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to provide an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
Newly qualified health visitor: Discussing vaccinations with families through health visiting contacts
Authors: Boddy Bethany
Published: October 2019

Bethany Boddy considers the important role health visitors have in discussing vaccinations with families through mandated contacts and sharing evidence-based research to promote vaccination uptake
Extracurricular Environmental Activities in Moroccan Middle Schools: Opportunities and Challenges to Promoting Effective Environmental Education
Authors: El-Batri Bouchta , Alami Anouar , Zaki Moncef , Nafidi Youssef
Published: October 2019

The study aims to promote relevant and effective environmental education (EE) through extracurricular clubs. For this, we studied the state of play of environmental activities (EA) carried out by 48 environmental clubs belonging to urban and rural areas of the Regional Academy of Education Fez-Meknes, Morocco. These extracurricular environmental clubs remain so far without formal environmental education programs. In this study, we identified the bulk of programs offered by extracurricular environment clubs, including types of scheduled activities and percentages of achievement and student beneficiaries in urban and rural settings. In addition, we have identified the main barriers to achieving certain environmental activities. The significant correlations detected between some of the variables studied allowed us to better explain the achievements and the weaknesses of these clubs. Finally, we have made recommendations to promote relevant and effective extracurricular environmental education.
The Stress Problems and the Needs for Stress Counseling of High School Students in Vietnam
Authors: Son Huynh Van , Vu Giang Thien , Thien Do Tat , Luong Tran , Hoi Dinh Duc
Published: October 2019

The correlation between the stress problems and the needs for high school students’ stress counseling in Vietnam is an unspecified issue that deserves attention. This study was conducted to test the hypothesis that there was no correlation between the stress problems and the needs for counseling of high school students in Vietnam. Survey of 1,200 high school students in Vietnam from grades 6 to 12 with questionnaires, the results show that the mean score of stress problems in high school students is 2.67 - corresponding to moderate level. Different levels of learning and living conditions are encountered in different student’s stress problems. The mean score for high school students' stress needs of counseling is 3.18 - corresponding to the optional level. Different levels of education have different needs for stress counseling. There is a strong correlation between high school students' problems and needs for stress counseling. The more problematic high school students experience in stress, the more they need to be counseled on this issue.
An Emotional Literacy Improvement (ELI) Program for EFL Teachers: Insiders’ Views
Authors: Eraldemir-Tuyan Seden
Published: October 2019

If the challenges of today's world are to be met, then there is a need to give more prominence to emotion in education, i.e.  indulging the personal, emotional and spiritual aspects of teaching, and promoting the teachers’ social-emotional competencies along with the schooling influence. In this respect, structuring the contents of in-service programs has gained vital importance in all fields of education including English Language Teaching (ELT). This action research study involved 17 EFL instructors to enhance their emotional literacy regarding learning in self and in others and consequently develop behaviors that would be caused by finding out about emotional intelligence. Relatedly, it was aimed to set up a framework of a teacher development program that the instructors at a foreign language school at a state university in Turkey improve their emotional literacy skills and create opportunities to impart these skills to their students as well as to people in their personal lives. The article reports on the participants’ and the researcher’s views regarding the maturation of an emotional literacy improvement program for in-service professional development purposes in ELT context.
Chinese Learning Anxiety on Foreign Students
Authors: Basith Abd. , Musyafak Nur , Ichwanto M. Aris , Syahputra Andi
Published: October 2019

The purpose of this study is to investigate the level of anxiety in learning Chinese, discover the dominant factors of anxiety in learning Chinese language and analyze differences in Chinese language anxiety based on gender, year of study and HSK in foreign students in Wuhan, China. The research method used was quantitative using a survey approach. There are 250 foreign students as the samples, consisting of 108 male and 142 female students. The data collection technique used is questionnaire called CLAS (Chinese Learning Anxiety Survey) adapted from FLCAS (Foreign Language Classroom Anxiety Survey). The data were analyzed using SPSS with descriptive statistical techniques and Multivariate Analysis. The results showed that Chinese language anxiety among foreign students is on a moderate level, with communication anxiety as the most dominant aspect. The male and female students have the same anxiety level in learning Chinese. The foreign students who had longer duration of learning Chinese and had higher HSK tend to have lower level of anxiety in learning Chinese. This showed that years of study and HSK were two factors that determine the high or low level of anxiety in learning Chinese for foreign students.
Leading Change in Teacher Education: Balancing on the Wobbly Bridge of School-University Partnership
Authors: Heinz Manuela , Fleming Mary
Published: October 2019

Initial teacher education (ITE) programmes have been critiqued widely for failing to connect educational theory with everyday practices in schools. More meaningful collaborations between schools and teacher education providers have featured prominently among key recommendations addressing the traditional theory-practice divide. This paper traces and critically analyses one ‘simplex’ story of initiating and leading a large-scale school-university partnership (SUP) network in the Republic of Ireland. Using a narrative approach, the protagonists and researchers of this SUP story bring their ‘simplex’ journey of doing and shaping SUP to life. Analysis of the Irish case study emphasizes the authentic transformation of teacher educators’ institutional identities as a powerful enabler of meaningful collaboration while also highlighting ethical dilemmas that arose for university tutors in the context of deeper relational engagement in the school-university cross-boundary space. Constrained in their ITE praxis by power relations and a disequilibrium of responsibilities, tutors’ doubts, discomfort and, at times, disillusionment led them to readjust their expectations with regard to SUP while also refocusing their energy and hopes in student teachers as collaborative future change agents.
Examining an English as a Foreign Language Teacher Education Program (EFLTEP)’s Curriculum: A Case Study in an Indonesian University
Authors: Sulistiyo Urip , Wiryotinoyo Mujiyono , Wulan Retno
Published: October 2019

This study aims to examine the English as A Foreign Language Teacher Education Program (EFLTEP)‘s curriculum of one state university in Jambi Province, Indonesia. This research employed a qualitative research design with case study involving 8 participants comprising of 4 beginner teachers and 4 teacher educators. This study used document analysis and interview as its instruments of data collection. The data revealed that beginner teachers perceived they need more practical aspects of pedagogical-related courses than theoretical aspects of teaching. Furthermore, a number of courses were overlapped and need to be redesigned, teaching and learning in large classes seems to be a crucial barrier to the effective implementation of the curriculum in the classroom, and the duration of the EFLTEP to completion is considerably longer than other pre-service teacher education programs. Based on the research findings, several recommendations have been provided. A curriculum should be able to balance the theory and pedagogical skill practice. Teachers, administrative, and other relevant stakeholders should deliberate and design the curriculum together considering other courses or credits to avoid overlapping subjects, eliciting the subjects, and integrated the similar subjects into one would be best choice to optimize the teacher education program, teachers and other stakeholders should allocate much time on Teaching English as Foreign Language (TEFL) practice and classroom management courses. At last, the curriculum should be in line with pre-service teachers’ needs to better prepare them with knowledge and skills for their teaching career in the future.
A Comparison between the Fifth Grade Intensive English Language Curriculum and the Fifth Grade English Language Curriculum: Students’ Achievement in Speaking
Authors: Kaya Suat
Published: October 2019

It is aimed, in this study, to compare the achievement level of the students taught with the fifth grade intensive English language curriculum (IELC) and the ones taught with the fifth grade English language curriculum (ELC) in terms of their speaking skills. With this aim, it is also intended to find out the failure behind the students’ speaking skills. Sequential explanatory strategy, which is one of the mixed-methods research designs, was used for this study as the aim was to further explain the quantitative findings. There were two groups of participants in this study. The first group included 64 fifth grade students selected from two different schools though simple random sampling, while the second group consisted of the five teachers teaching the fifth grade IELC. Two instruments developed by the researcher were utilized to collect data. The first instrument was an achievement test developed to measure students’ success in speaking skills, while the second instrument was a semi-structured interview schedule developed to collect data from the teachers implementing the fifth grade IELC. The quantitative data collected through the achievement test were analyzed with descriptive statistics including means and standard deviations and inferential statistics through independent samples t-test which was used to compare the two groups of students’ achievement levels, while the qualitative data gathered through the semi-structured interviews were analyzed with content analysis. The findings indicated that only one objective was attained by the students, the results of independent samples t-test indicated that there was not a significant difference in the achievement levels of the students taught with the fifth grade IELC and the ones taught with the fifth grade ELC. The reasons behind this failure was found to be resulting from teacher-related, student-related, and Ministry of National Education (MoNE)-related factors referring to implementation problems rather than curriculum design.
Democratic care ‘for all’ and trade-offs: the public solution, civil society and the market
Authors: Stensöta Helena Olofsdotter
Published: October 2019

Scholarly discussions on the political power of care and care ethics have considered democratic notions such as how care recipients can make their voices heard, but the problem has recently been expanded to include how care needs can be met in a manner consistent with democratic commitments to justice, equality and freedom for all, which addresses equal access to care. Assessing the possibilities to meet this requirement shows different trade-offs in civil society, the market and publicly funded solutions. It seems that the ideals of care ethics, such as democratic access to care, sit more comfortably with publicly funded care.
Incidence of thyroid cancer and epidemiologic determinants of the condition: Role of ionizing radiation
Authors: Tronko N. D. , Boguslavsky V. P. , Prisyazhnyuk A. Ye. , Bolshova Ye. V.
Published: October 2019

As a result of the Chernobyl accident, a significant part of Ukraine was contaminated with radionuclides. According to UNSCEAR, the activity of material released into the environment from the destroyed active zone of the reactor was about 50 MKi, among which the share of radionuclides of iodine, cesium and tellurium was 10-20%. Despite the fact that the prompt implementation of iodine prophylaxis made it possible to reduce the dose load on the thyroid gland, nevertheless, a significant part of the child and adult population received radiation doses of the thyroid gland, which pose a serious danger in the development of possible long-term oncological consequences. Based on dose calculations according to the most conservative model of single dose of radioactive iodine, the number of children living in the 8 most affected areas of Ukraine affected by iodine radionuclides and exposed to doses in excess of 200 cGy is estimated to be 12,000 or more, in the dose range up to 200 cGy - 79 500, up to 30 cGy - 38 000.

Available information on thyroid doses in Ukraines population, on the one hand, and information on the carcinogenic effects of this organs radiation, accumulated to date in the world, on the other hand, indicate the need for carefully planned epidemiological studies aimed at assessing the risk of this pathology in victims. At the same time, the effectiveness of such studies, and, consequently, the development of preventive measures to reduce the effects of radiation in the future, will largely depend on taking into account the characteristics of the epidemiological study of the role of the radiation factor in the development of thyroid cancer.

In connection with the foregoing, the aim of this work was to generalize the information accumulated to date in the world, reflecting deficiencies in the study of the epidemiology of radiation-induced thyroid cancer, as well as confirming the need for further development and improvement of these studies.
Workshop on «Essential» Phospholipids in the Treatment of Diabetes Mellitus and Dyslipidemias
Authors: Bespalova V. A. , Kundurovich M.
Published: October 2019

A scientific and practical symposium Essential phospholipids in the treatment of diabetes mellitus and dyslipidemia organized by RON-PULENK RORER (Cologne, Germany) was held at the State Central Scientific Medical Library of the Ministry of Health of Russia.

The basic concept of the development of dyslipidemia (DLP) and the working classification of this metabolic state were presented in a report by Yu. A. Knyazev (Moscow). In the message K. Gundermann et al. (Cologne, Germany) the mechanism of action of essential phospholipids (EPL) at the molecular level, the level of insulin receptor and postreceptor interactions in cytomembranes, as well as in lipolytic and cholinesterizing enzyme systems was described.

The feasibility of using EPL preparations for the prevention of diabetic angiopathies (AP) by transplanting pancreatic incretory cell cultures, with conservative and surgical treatment of AP with the aim of stabilizing or even reversing the development of atherosclerotic vascular lesions, was substantiated in a report by A. A. Chirkin et al. (Vitebsk, Belarus). The results of the study of intravascular microcirculation in patients with diabetes with clinical signs of AP made it possible to evaluate lipostabil (a drug containing EPL and prescribed together with hypoglycemic agents) as an effective tool in the plasma-cell type of microcirculatory disorders in patients with diabetes aged 19 to 68 years (I. M Kakhnovsky et al., Moscow).

Under the influence of lipostabil forte, an increase in insulin sensitivity is possible (L. L. Vakhrusheva et al., Moscow), which underlies a decrease in the need for exogenous insulin and a tendency to normalize indicators of carbohydrate and fat metabolism, the level of counterinsulin hormones. 6 months after the start of lipostabil forte administration, an inhibition of AP progression was noted against the background of an adequate dose of insulin.
The national register of diabetes mellitus: incidence of noninsulin-dependent diabetes and its complications (communication 1)
Authors: Dedov I. I. , Suntsov Yu. I. , Kudryakova S. V. , Ryzhkova S. G. , Volkov V. S. , Inyakina T. I. , Lisitsyn V. Yu. , Baslerova Yu. A. , Gubanov N. V.
Published: October 2019

The organizational structure of the National Register of Diabetes Mellitus (NRDM) is discussed, and results of the analysis for one of the territorial centers of NRDM in the Central Administrative District of Moscow are presented. The data indicate that the organization of NRDM appreciably improves the level and quality of medical statistical monitoring of the epidemiological situation as regards the above disease, extends the scope of available information needed for planning and economic validation of diabetologic service in public health, and helps develop the strategy of primary and secondary prophylaxis of diabetes and outline the main trends in epidemiological research. The register data may be used as the database for drug and food plants when planning antidiabetic agents and dietetic foodstuffs.
Pituitary prolactotropic function in patients with "inactive" pituitary adenoma
Authors: V. Vax V. V. , Marova Ye. I. , Goncharov N. P. , Kasumova S. Yu. , Kadashev B. A.
Published: October 2019

Pituitary prolactotropic function was retrospectively analyzed in 23 patients with "inactive" pituitary adenoma (8 oncocytomas and 15 zero-cell adenomas) verified by electron microscopy. Before surgery basal prolactin level, prolactin concentrations in tests with thyrotropin-releasing hormone (TRH) and Parlodel, and daily fluctuations in prolactin levels in the blood were measured in all the patients. Moderate hyperprolactinemia was detected in 11 (47.8%) patients, which was often associated with galactorrhea-amenorrhea in women and with sexual dysfunction in men and was related to disturbed hypothalamo-pituitary relationships in cases with large adenomas. Irrespective of the basal level of prolactin, its secretion in response to TRH was abnormal: the reaction was reduced, particularly in patients in whom the tumors were associated with hyperprolactinemia. Acute loading with Parlodel led to a reliable reduction of prolactin concentration in the blood both in controls and in patients with normo- and hyperprolactinemia. A reduction of prolactin level by more than half in patients with inactive pituitary adenomas and moderate hyperprolactinemia in response to Parlodel loading, similarly as in normal subjects, confirms the functional type of hyperprolactinemia in such patients. Daily fluctuations of prolactin level were revealed in patients with large or giant adenomas.
Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation
Authors: Bezerra Wanessa da Silva Peres , Ferreira Júnior Marcos Antonio , Azevedo Isabelle Campos de , Cardoso Mayk Penze , Cardoso Andreia Insabralde de Queiroz , Frota Oleci Pereira , Ivo Maria Lúcia , Flores Vanessa Giavarotti Taboza , Gonçalves Elenilda de Andrade Pereira
Published: October 2019

The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia.
Diversity and population dynamic of Tabanidae (Diptera) in the cerrado-pantanal ecotone
Authors: Barros Antonio Thadeu Medeiros de , Koller Wilson Werner , Teodoro Paulo Eduardo
Published: October 2019

Tabanid (Diptera) species are associated with the mechanical transmission of several pathogens to both domestic and wild animals around the world. The aim of this study was to evaluate the diversity, abundance, and seasonal dynamic of tabanids in the Cerrado-Pantanal ecotone in Miranda, state of Mato Grosso do Sul, Brazil. Tabanids were collected once a month, from June 2001 to May 2003, for seven consecutive days per collection, using canopy and nzi type traps baited with a chemical attractant (1-octen-3-ol). A total of 6,492 individuals from 39 species and 18 genera was collected, which increases from 25 to 34 the number of tabanid species reported for the studied region. Tabanus occidentalis Linnaeus, 1758 (62.21%) was the most abundant species throughout the collection period, followed by Lepiselaga crassipes (Fabricius, 1805) (7.19%) and Tabanus sorbillans Wiedemann, 1828 (5.68%). The peak of the tabanid population was reached during the rainy season, which is the period of the highest potential risk of mechanical transmission of pathogens by these insects in the studied region.
Schinus terebinthifolius essential oil and fractions in the control of Aedes aegypti
Authors: Bortolucci Wanessa de Campos , De Oliveira Herika Line Marko , Silva Eloísa Schineider , Campo Caio Franco de Araújo Almeida , Gonçalves José Eduardo , Piau Junior Ranulfo , Colauto Nelson Barros , Linde Giani Andrea , Gazim Zilda Cristiani
Published: October 2019

Several technologies have been developed to control Aedes aegypti, mainly studies on isolated plant molecules. The Schinus terebinthifolius (Raddi) (Anacardiaceae), popularly known as pink pepper is a plant widely used in reforestation of degraded areas and its fruits are used as condiments. The objective of this work was to investigate the potential of essential oils (EOs) and fractions (FRs) obtained from fresh fruits and leaves of S. terebinthifolius. The EOs were obtained by hydrodistillation (2 hours), fractionated on a chromatographic column using as the stationary phase silica gel 60 (0.063-0.2mm), mobile phases: n-hexane, dichloromethane, ethyl acetate and methanol and chemically evaluated by gas chromatography coupled to mass spectrometer (GC/MS). EOs and FRs were tested against larvae of the third stage and pupae of  Ae. aegypti by Immersion Test at concentrations ranging from 500.00 to 0.003 mg mL-1 (v/v). The hexane FRs obtained from fruits and leaves were the ones that showed the greatest activity on the larvae (LC99.9= 0.60 mg mL-1 and LC99.9 0.64 mg mL-1, respectively) and pupae (LC99,9 = 2.51 mg mL-1 and 2.61 mg mL-1, respectively). These results were confirmed by the anticholinesterase activity where the hexane (fruit and leaf) FRs presented the highest inhibitory potential on the acetylcholinesterase enzyme (0.156 mg mL-1 and 0.312 mg mL-1, respectively), suggesting the likely mechanism of action. The larvicidal potential can be explained by the presence of the major compounds bicyclogermacrene and germacrene D in the hexane FRs, indicating in this way that they may replace or even act in synergisms with conventional chemical larvicides. In this way the present study opens the field for new researches, aiming the development of products with the compounds bicyclogermacrene and germacrene D, as an alternative in the control of this culicide.
Phytochemical screening and toxicity of Crambe abyssinica Hochst extracts on Solanum lycopersicum L., Euphorbia heterophylla L., Bidens pilosa L. and Glycine max (L.) Merril
Authors: Spiassi Ariane , Fortes Andréa Maria Teixeira , Guedes Luciana Pagliosa Carvalho , Lima Gislaine Piccolo de , Meira Rennan Oliveira , Valmorbida Raquel , Mendonça Lorena Camargo de
Published: October 2019

This study aimed to identify the main groups of secondary compounds from Crambe abyssinica and evaluate the bioactivity of the hexane, ethyl acetate and methanol extracts on the seed germination and seedling development of tomato, wild poinsettia, hairy beggartick and soybean. The phytochemical screening considered the presence or absence of total saponins, triterpenoids, flavonoids, coumarins, tannins, phenols and alkaloids. In the seeds it was evaluated: germination percentage, germination velocity index, average germination time, index of allelopathic effects, shoot and root length and seedlings dry matter. In the phytochemical screening it was observed that each solvent extracted different compounds. Flavonoids were found only in the ethyl acetate extract and saponin only in the methanol extract. A high allelopathic effect of hexane, ethyl acetate and methanolic extracts of crambe on the bio-indicator species tomato was observed. The hexane and ethyl acetate extracts also showed inhibitory effect on the weed hairy beggartick and did not present negative effects on soybean. There is the possibility of isolating the bio-active compounds of crambe and use them as a bio-herbicide to the alternative control of the weed hairy beggartick.
Yield and quality of cherry tomato fruits in hydroponic cultivation
Authors: Dias Nildo da Silva , Diniz Adriana Araújo , Morais Patrícia Ligia Dantas de , Pereira Gledyson Dos Santos , Sá Francisco Vanies da Silva , Souza Bruno Goulart de Azevedo , Cavalcante Lourival Ferreira , Ferreira Neto Miguel
Published: October 2019

Because of the food and industrial importance of tomato, it holds great significance, and is one of the most produced species using the hydroponic cultivation systems. The objective of this study was to evaluate the effects of different concentrations of nutrient solution on the production and quality of cherry tomatoes (Lycopersicon esculentum ‘Samambaia’) grown in a hydroponic system in protected conditions. The experiment was conducted in pots filled with coconut fiber substrate using a randomized complete block design with four replications and six plants per plot. Five concentrations of nutrients were evaluated (50, 75, 100, 125, and 150% of the standard nutrient solution); the solutions produced the following electrical conductivities: 1.8, 2.0, 2.6, 3.4, and 3.9 dS m-1, respectively. At 90 days after transplanting, the tomato fruits were harvested, at which time the production variables and post-harvest quality of mature fruits were determined. The best production and post-harvest quality indexes of cherry tomatoes (‘Samambaia’) were found when using 111% of the standard nutrient solution, corresponding to the concentrations of 9.44, 2.44, 2.22, 6.44, 4.11, 2.44, and 2.78 mmolc L-1, of NO3-, NH4+, P, K, Ca, Mg, and S, respectively; and 66.6, 55.5, 14.4, 1.89, 0.56, and 0.44 mmolc L-1, of Fe, B, Mn, Zn, Cu, and Mo, respectively. Nutrient solutions with electrical conductivity above 2.89 dS m-1 severely reduced the fruit yield of cherry tomatoes.
Adaptability and stability of soybean cultivars in four sowing seasons
Authors: Bicalho Thaís Ferreira , Nogueira Ana Paula Oliveira , Hamawaki Oswaldo Toshiyuki , Costa Solange Celestino , Morais Júnior Ivair José de , Silva Nathália Salgado , Hamawaki Raphael Lemes , Hamawaki Cristiane Divina Lemes
Published: October 2019

In recent decades, the expansion of soybean production in Brazil has been observed. This advance was motivated by the search of environments with better cultivation conditions, as well as the development of genotypes with wide adaptation. The diversity of "environments" hinders the process of selection and recommendation of cultivars, since the productive potential of a cultivar is given as a function of the sum of the genotype effect, the environment and the interaction between the latter two (G x E). In the case of this G x E interaction, regional studies are necessary in order to detail the differential behavior of the cultivars. Thus, the objective of this work was to evaluate the genotype interaction by environments, adaptability and phenotypic stability for grain yield, of fifteen soybean cultivars, in four sowing seasons, in order to identify cultivars that combine high productive potential, predictability of behavior and adaptation to the edaphoclimatic conditions of Uberlândia-MG. The trials were conducted at the Experimental Farm Capim Branco, in Uberlândia-MG. Fifteen soybean cultivars were evaluated in four sowing seasons (October 23, 2016, November 19, 2016, December 10, 2016 and January 14, 2017), in relation to grain yield. The experimental design was of randomized complete blocks, with three replications, in each season. Data were submitted to individual and joint analyzes. The G x E interaction was decomposed by the method proposed by Cruz and Castoldi (1991). The differential behavior of the genotypes was detailed by the adaptability and phenotypic stability by the methods of Eberhart and Russell (1966), Lin and Binns (1988) modified by Carneiro (1998), AMMI and Centroid. By the analysis of joint variance, it was observed the existence of the cultivar interaction by sowing times (C x E), for the grain yield trait, at the 5 % probability level by the F test. The C x E was predominantly complex in nature. The cultivar CD 2737 RR presented satisfactory results for the four sowing seasons in Uberlândia-MG, with high grain yield and predictability of behavior, by the evaluated methods. The cultivar NS 6909 IPRO was classified into favorable environments by the methods of Eberhart and Russell (1966) and Lin and Binns (1988) modified by Carneiro (1998). Considering Lin and Binns (1988) modified by Carneiro (1998) and Centroid the cultivar that is also classified for this cultivation condition is UFUS 8301. By AMMI, UFUS 7415, CD 2737 RR and UFUS Milionária are considered stable and adaptable.
Saline stress effect on cowpea beans growth under biofertilizer correction
Authors: Pereira Ednangelo Duarte , Marinho Albanise Barbosa , Ramos Elísia Gomes , Fernandes Chrislene Nojosa Dias , Borges Francisca Robevania Medeiros , Adriano Jilson de Nazaré José
Published: October 2019

New strategies to increase growth and food crops productivity in saline soils are priorities in the research. The experiment was carried out in a pot to investigate the growth of cowpea cv. Canapu in response to saline stress under the correction of a mixed biofertilizer. Five irrigation water salinity levels and three doses of the mixed biofertilizer were tested, with four replicates at each level. The increase in salinity level resulted in reductions in stem diameter, leaves number, shoot biomass and roots. The mixed biofertilizer use was able to minimize the effect of salinity in all analyzed variables, improving the cowpea growth and development, protecting from saline stress negative impacts. In addition, the mixed biofertilizer use may be an option to improve crop growth and productivity in salt affected soils.