bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Role of Histopathological Examination in the Diagnosis Psoriasiform Sarcoidosis (Clinical Case)
Authors: Алиев А.Ш. , Мухамедов Б.И. , Колдарова Э.В. , Пягай О.Г.
Published: October 2022

Саркоидоз – системное заболевание с хроническим течением, характеризующееся образованием специфических гранулем в различных органах и тканях. По современным представлениям, саркоидоз является болезнью нарушенной иммунореактивности с особой реакцией организма на воздействие различных факторов. В статье представлен клинический случай атипичной формы саркоидоза – псориазоподобный саркоид у пациентки 51 года. Данный клинический случай свидетельствует о трудностях диагностики из-за редкой встречаемости в практике врача-дерматолога, важности патогистологического исследования, которое позволяет проводить дифференциальную диагностику с другими заболеваниями кожи, имеющими сходную клиническую картину.

Sarcoidosis is a systemic disease with a chronic course, characterized by the formation of specific granulomas in various organs and tissues. According to modern concepts, sarcoidosis is a disease of impaired immunoreactivity with a special reaction of the body to the influence of various factors. A clinical case of an atypical form of sarcoidosis – psoriasis-like sarcoid in a 51-year-old patient is presented. This clinical case indicates the difficulties of diagnosis due to the rare occurrence in the practice of a dermatologist, the importance of histopathological examination, which allows differential diagnosis with other skin diseases that have a similar clinical picture.
Towards Real-Time Human Behavior Understanding: A Suboptimal Shape Descriptor
Authors: SONUGUR Güray , ÇAKI Elif Ebru , AKAN Simge Ayşe , GÖKÇE Celal Onur
Published: October 2022

In this study, two novel shape descriptors are proposed to be used in human behavior understanding problem. First is optimal shape descriptor, which has high performance but works very slow due to high algorithmic complexity. Second is suboptimal shape descriptor, performance of which is very close to optimal one, but works much more faster. Optimal means using minimum data to represent maximum knowledge. Algorithms are run on Weizmann dataset and results are shown both as figure and video link. Classification was performed using 12 statistical features extracted from the data sets' human silhouettes. An accuracy rating of 92 percent was obtained by using Euclidean distance in classification.
Ağ Topolojisi İlişkisi ile Bağlantı Tahmin Yöntemlerinin Performanslarının Keşfi
Authors: ORMAN Günce Keziban
Published: October 2022

Karmaşık ağ analizinde öne çıkan konulardan biri, ağ tabanlı öneri sistemlerinin veya eksik bağlantıların bulunmasının önemli bir bileşeni olan bağlantı tahminidir. Literatürde iki düğüm arasında bağlantı bulunma şansını ölçümlemeye dayanan birçok farklı bağlantı tahmini yöntemi vardır. Bu yöntemler ağın farklı topolojik özelliklerini kullanır. Çok farklı stratejiler kullanan yöntemler bulunmasına rağmen, önceki çalışmalar yalnızca yöntem başarısına odaklanmış ama bu yöntemlerin performansının ağın topolojisi ile ilişkisini yeteri kadar incelememiştir. Bu çalışmanın ana motivasyonu farklı ağ topolojilerininin bağlantı tahminindeki rolünü bir ortaya koymaktır. Böylece ağın topolojik özelliklerine göre bağlantı tahmin yöntemi seçimi özelleştirilebilir. Çalışmanın iki temel katkısı, ilk olarak, büyük bir deney düzeneğinde farklı topolojik özelliklere sahip sosyal, biyolojik ve bilgi ağlarında iyi bilinen performans ölçümleriyle farklı bağlantı tahmin yöntemlerini karşılaştırmak ve ikincisi, bağlantı tahmin yöntemlerinin performansı ile ağ topolojisi arasındaki olası ilişkinin incelenmesi olarak sıralanabilir. Sonuçlara göre, ağ topolojisine bakılmaksızın küresel yöntemlerin diğerlerinden daha başarılı olduğunu gördük. Ayrıca, ağda özvektör merkezileşmesinin yüksek olmasının eksik bağlantı tahmin performansını etkileyebileceği sonucuna ulaşıldı.
INDUSTRIAL PARKS - MODERN MODEL OF SPATIAL LOCALIZATION OF INDUSTRIAL PRODUCTION
Authors: Radygina S.V.
Published: October 2022

In this article, the spatial localization of industrial production is considered as a way of innovative development and achieving the sustainability of the country's economic system, the tools of internal and external localization and legally approved priorities in the field of industrial cooperation are highlighted. An effective mechanism for building cooperation chains and based on long-term cooperation between residents is the format of an industrial park. The peculiarities of the creation and functioning of such industrial sites are determined, the minimum requirements imposed by the state on industrial parks to receive subsidies from management companies and residents to create and modernize infrastructure and apply preferential tax rates. The article also analyzes the dynamics of industry development based on the number of existing and created industrial parks, their occupancy by residents, the volume of investments made in production and infrastructure, the growth rate of creating new jobs and the geographical distribution in the context of federal districts. It is concluded that there is a need for organized production sites with the necessary infrastructure managed by a professional organization that eliminates the need for companies to engage in non-core activities. The reasons for the demand for industrial parks are considered, including those related to obtaining various economic effects in the process of operating activities from interaction with other residents through cooperation and localization of production.
NEW INTERNATIONAL DIVISION OF LABOR AND RUSSIA's POSITION IN IT
Authors: Lukichev P.M.
Published: October 2022

The COVID-19 pandemic and the subsequent politicization of the solution of economic problems have created a new economic reality. This article is devoted to the consideration of the possibilities and problems of the formation of a new international division of labor. The scientific and practical works of Russian and foreign scientists in the field of the international division of labor and global trade were used as the methodological basis of the study. The division in the analysis into the short term and the long term is necessary to study the sequence of steps in the formation of a new international division of labor. The author identifies the following manifestations of the new international division of labor: the crisis of "supply chains", the deformation of the global and national labor markets, the politicization of the solution of economic issues at the international level, the significant lag of economic theory from real business processes, the impact of climate change on the formation of a new international division of labor and the transition from a "free trade" policy to a "fair trade" policy. The "supply chain" crisis has shown that the order of supply in international trade, based on the "just in time" system, could not withstand the external shock, causing shortages and inflation. The deformation of labor markets is manifested in COVID-motivated automation, in the "migration trap", in the increased polarization of employment. The countries of the “golden billion”, having been defeated in competition in the global market, are striving for a political solution to economic problems. The EU is trying to play the game of European super monopoly and super monopsony. The possibility of a political solution to the problems of global economic competition is based on the fact that changes in the real economy that have taken place in recent decades have not adequately changed the international financial sphere. Regardless of the current geopolitical situation, in the long term, the expansion of the use of new technologies and artificial intelligence creates the basis for the international division of labor of the next level. To maintain and potentially improve its place in the international division of labor of the Russian Federation, a consistent transition from the “inertial” to the “innovative” path of development is necessary.
COMPUTER USER IDENTIFICATION POSSIBILITIES FOLLOWING THE KEYPAD DISPLAYS
Authors: Kaminsky A.M. , Rubtsov V.G.
Published: October 2022

Identification of a computer user in modern conditions allows not only to ensure the protection of information, but also has a special forensic significance. The developed systems of user authentication by keyboard handwriting, based on the identification of an individual dynamic stereotype of working with the keyboard (the intervals between keystrokes and the time of holding the keys), make it possible to identify the user only during data entry. When investigating crimes using computer technology, in most cases it is necessary to install the user after a considerable time after using the computer. The conducted pilot study found that the individual features of the dynamic stereotype of working with the keyboard are manifested in stable traces-displays on the keyboard keys. The features of the stereotype are manifested in the area where the keys are touched. At the same time, the touch area can be different for different keys: top, bottom, right, left, center, one of the corners. This creates a high variability, individuality of working with the keyboard. With prolonged use, micro-damages of the surface are formed in these areas - scuffs, scratches. With relatively short-term use, the areas with the greatest stratification of the fatty substance can be used as traces. To solve the problem of user identification, it is necessary to solve the problem of distinguishing the traces of several users on the same keyboard.
ON THE ISSUE OF THE MOMENT OF THE END OF INDIVIDUAL CRIMES IN THE SPHERE OF FOREIGN ECONOMIC ACTIVITY
Authors: Nikiforova A.A.
Published: October 2022

In the presented article, the author, based on the analyzed examples of investigative and judicial practice, studied the approach of the law enforcement officer within the description of the signs of the subjective side, as a result of which the facts of disclosure of such signs through the attitude of the guilty person to socially dangerous consequences when committing crimes in the field of foreign economic activity (art. 193, 193, 194, 200, 200, 226, 229 The Criminal Code of the Russian Federation); at the same time, attention is drawn to the fact that these elements of crimes are designed as formal, that is, the objective side includes only a socially dangerous act, and the moment of completion is associated with the moment of the commission of the act, therefore the author proves and comes to the conclusion that the indication of socially dangerous consequences and the attitude of the perpetrator to them the guilty verdict does not seem to comply with the provisions of the criminal law; based on the conducted research, the author states that such a conclusion is, first of all, necessary for competent law enforcement when solving the issue of bringing to criminal responsibility persons who have committed crimes in the field of foreign economic activity.
QUESTIONS OF QUALIFICATION OF CYBER-EXTORTION
Authors: Styazhkina S.A.
Published: October 2022

The problem of ensuring information security today comes to the fore. Information is becoming an increasingly valuable object that requires special protection. Society, transforming into a digital one, is becoming increasingly dependent on information resources and information and telecommunication networks. Recently, cases of the use of encryption programs for information have become widespread, with subsequent demands for the payment of large sums of money for the preservation of data and their decryption. To date, "cyber extortion" falls under the signs of crimes in the field of computer information, such as unauthorized access to computer information (Article 272 of the Criminal Code of the Russian Federation) and the creation, use and distribution of malicious computer programs (Article 273 of the Criminal Code of the Russian Federation). In our opinion, this is not enough. It is proposed to supplement Article 163 of the Criminal Code with additional objective signs aimed at protecting computer information.
Photo Collages and Near-Peer Interviewing: Scaffolding Data Collection in Youth Participatory Action Research Projects With Children
Authors: Baggett Hannah Carson , Anderson Amy J. , Andrzejewski Carey E.
Published: October 2022

In this brief report, we describe photo collages generated by youth researchers as a photo-elicitation technique in youth participatory action research focused on food (in)security. The approach was implemented with 11 high school students over the course of one semester in an agriscience class at a K-12 alternative school. Student researchers used photo collages as data collection scaffolds within near-peer interviews with elementary students to prompt sharing about food experiences and inequality. This report illustrates how youth-led photo collages are a useful approach to engaging youth as co-creators of knowledge by scaffolding research capacity for high school students and engaging elementary students in research.
Programming and Researching With Youth in Cultural Institutions – a Brief Reflection on a Cross-Institutional Youth Advisory Board
Authors: Silva Carolina
Published: October 2022

This brief report describes the operational processes and participatory methods involved in setting up, managing and mediating a cross-institutional youth advisory board. Youth advisory boards in museums give young people opportunities to co-program with and for their peers, as well as to have an active and visible role inside institutions. Framed by the research project Youth in Museums, the youth advisory board Listening Lab – Youth, Culture, Participation, was co-organized and developed with five cultural institutions in Lisbon, Portugal. These included the Museum of Art, Architecture and Technology (MAAT), BoCA – Biennal of Contemporary Art, Casa da Cerca – Contemporary Art Centre, LU.CA – Luís de Camões Theatre and the Municipal Galleries. Young people, aged 15 to 25, were invited to participate in group roundtables to discuss specific issues related to youth arts programs. In the sessions with the youth advisory board I combined a semi-structured approach with participatory methods that activated collective processes of meaning making.
Effects of electron charging and magnetization configuration on the electronic properties of Ni/C60/Ni single molecule transistors
Authors: Yoshida Kenji , Hamada Ikutaro , Hirakawa Kazuhiko
Published: October 2022

We report charge-state-dependent electron transport through single C60 molecule transistors with ferromagnetic Ni electrodes. We have found that the addition of an extra electron onto the C60 molecule in its equilibrium state leads to strong enhancement in the coupling between the C60 molecule and the Ni electrodes. Furthermore, even the magnetization configuration of the Ni electrodes modulates the hybridization in this strong coupling region, giving rise to a very large conductance change upon magnetization reversal. This work demonstrates great potentiality of ferromagnetic metal electrodes in controlling transport characteristics of single molecule transistors through modulation of charge states and/or magnetization configurations.
Contrasting aspects of the physical and physiological dormancy shown by seeds from different peach rootstocks
Authors: Menegatti Renata Diana , Lima Marcos Aurélio C. , Souza Aline G. , Smiderle Oscar José , Bianchi Valmor João
Published: October 2022

Considering that cultivars of peach rootstocks selected to be propagated by seeds show variation in the degree of physiological dormancy and peculiarities regarding the limitation imposed by the endocarp, it is essential to define the cold stratification period and the ideal temperature to be used during the pre-germination treatment. Isolated for each cultivar, knowledge of these variables which will provide viability in the production of peach rootstocks via seeds, in the presence of the endocarp, at a larger scale. Two germination tests were carried out, in a completely randomized experimental design and 4 x 3 factorial scheme, with four replications, each one consisting of 25 endocarps. The first experiment was performed with four cultivars (Aldrighi, Capdebosq, Okinawa Roxo and Tsukuba 1) and three stratification temperatures (1°C, 4°C and 7°C) for a period of 90 days. For the second experiment, the same cultivars were used, two temperatures (7°C for ‘Aldrighi’ and ‘Capdebosq’ and 4°C for ‘Okinawa Roxo’ and ‘Tsukuba’) and three stratification periods (40, 80 and 120 days), followed by sowing in substrate under greenhouse conditions for a period of 45 days, with subsequent endocarp breaking and re-sowing. The pre-germination treatment at 7°C for 90 days is sufficient to obtain high germination percentage of ‘Aldrighi’ and ‘Capdeboscq’ seeds in the presence of the endocarp. Under the stratification conditions tested, the seeds of ‘Okinawa Roxo’ and ‘Tsukuba 1’ require rupture of the endocarp to reactivate the germinative embryonic process.
Genetic and ampelographic characterization of grapevine accessions maintained in the Lebanese national collection
Authors: Chehade Ali , Chalak Lamis , Merheb Joe , Elbitar Ahmad , Rmeily Elie , Madi Nagham , Massaad Mark
Published: October 2022

Safeguarding grapevine biodiversity is one of the main concerns in viticulture today. Management of ex situ collections requires a comprehensive characterization of the conserved germplasm to provide basic material for selection and breeding programs. In this study, the local grapevine germplasm conserved at the national collection of the Lebanese Agricultural Research Institute and composed of 43 accessions was submitted to a genetic and ampelographic study. Nine ISSR primers, previously developed in grapevine, were used in this study. These primers generated a total of 51 bands, of which 77.7% were polymorphic allowing the differentiation of 41 genetic profiles vs. one case of synonymy that was recorded among three accessions. Ampelographic characterization was conducted using a set of 33 descriptors established by the International Office of Vine and Wine and related to leaf, bunch, and berry. Principal component analysis identified 12 descriptors i.e. veraison date, maturity date, berry length, upper and lower vein pigmentation, bunch density, bunch weight, sugar content at harvesting, flesh of juiciness, berry weight, flesh firmness, and color skin, as being the most discriminating descriptors. The correlation between the ISSR clustering and the ampelographic one was not significant (r=0.26) because of the divergence of accessions groups, except for the three accessions synonymy case which was confirmed in both dendrograms. Finally, this comprehensive evaluation of the existing local gene pool of grapevine revealed a substantial diversity. It would further allow the promotion of the valuable accessions directly through multiplication schemes, and their sustainable utilization in genetic improvement programs.
Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice
Authors: Mohamed Idriss H.
Published: October 2022

Abstract: The study was conducted to evaluate the toxic effect of different concentrations of cyclophosphamide (CTX) by inducing leukopenia. Adult female Swiss albino mice weighting (20±4g) arranged in three groups of six animals each housed. A control mice saline PBS solution (group I), mice treated with 200 mg/Kg (4mg/mouse) cyclophosphamide, High dose (group II) and mice treated with treated 100 mg/kg (2mg/mouse) body weight Low dose (group III) for three weeks. Cyclophosphamide causes a significant decrease (P < 0.01) in total leukocyte count (TLC), total erythrocyte count (TEC), and red blood cell distribution (RDW) in all groups compared to the control group of mice. Observed leukopenia inform marked reduced in the absolute numbers of lymphocytes, monocytes, and neutrophils in comparison to the control group of mice. The results indicate that cyclophosphamide alters the blood profile only after high doses while low doses had the least impact on blood pictures. Cyclophosphamide causes a significant increased (P < 0.01) in activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum after CTX treatment with no effect on the serum albumin level compared to the control group. While lower doses had less effect on liver enzymes.
Hematological Parameters and Blood Smear Effects of Tramadol on Male Rabbits
Authors: Khaled Fayrouz A. , Younus Amaal A. , Sale Rui M.
Published: October 2022

Abstract: Analgesics are a bunch of drugs that act totally different ways on the central apprehensive framework to absense of pain and alleviation from torment. It is in this manner imperative to ponder the impacts of organization these analgesics to decide the side impacts for them utilize. Hence we decided to study the hematological effects of tramadol on male rabbits. Tenth rabbits were arbitrarily partitioned into two break even with bunches (each bunch five rabbits). The primary gather was utilized as a control. The moment gather was utilized to consider the impact of tramadol (50 mg/kg body weight) for six weeks. Hemoglobin (Hb) substance, ruddy blood cells (RBCs) number and hematocrit (Hct) esteem diminished, whereas white blood cells (WBCs) and platelets tallies expanded after tramadol organization. Verbal organization of tramadol induced significant changes within the morphology of erythrocytes. In rabbit treated with tramadol the cells were appeared change in typical shape from star molded to sickle cells. The ponder appeared the destructive impacts of tramadol on the hematological parameters and blood spread on mail rabbits.
Predicting ICU Length of Stay in COVID-19 Patients Using a Multivariable Model Incorporating Clinical, Laboratory, and Imaging Features
Authors: Azadbakht Javid , Lajevardi Zahra sadat
Published: October 2022

Abstract: Objective: To predict ICU length of stay (LOS) using a multivariable model incorporating clinical, and laboratory and imaging features in hospitalized COVID-19 patients, thereby stratifying patients and allocating resources accordingly. Methods: In this retrospective cohort study, 139 hospitalized patients (Aged between 3 to 99) with rRT-PCR confirmed COVID-19 pneumonia requiring intensive care, which had been discharged or deceased, were enrolled. Demographic, clinical, and laboratory findings of eligible patients were all extracted from electronic medical records and, if needed, through phone calls. Semi-quantitative CT severity score (CTSS) was calculated and assigned to each encoded patient independently and blindly. We used cox regression model to investigate the prognostic role of semi-quantitative CTSS, clinical and laboratory features to anticipate ICU-LOS. Results: 139 patients with rRT-PCR confirmed COVID-19 pneumonia (including 60 females and 79 males) with a mean age of 58.52 ± 20.58 (ranging from 3 to 99) were included. CTSS was not predictive of ICU-LOS. Additionally, CTSS of more than 11 was predictor of mortality (sensitivity, 60.3%; specificity, 58%; AUC, 0.605; 95% confidence interval, 0.508-0.702; P-value, 0.034), and CTSS of above 10 was predictor of oxygen therapy dependency (sensitivity, 70.2%; specificity, 68%; AUC, 699 /0; 95% confidence interval, 0.580-0.818; P-value, 0.002). CTSS was not significantly associated with respiratory rate and on-admission dyspnea, while it was inversely related to air-room SpO2 on the first day of admission (P <0.0001, r = -0.341). Conclusion: CTSS is capable of anticipating mortality rate and the chance of undergoing supportive oxygen therapy during ICU hospitalization, while it does not predict ICU-LOS, rate of mechanical ventilation, or corticosteroid therapy.
Chlorogenic Acid a Potent Anti-inflammatory Agent: In-Silico Molecular Docking approach
Authors: Bano Shayara , Malik Jitender K.
Published: October 2022

Abstract: Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound of the hydroxycinnamic acid family. This polyphenol has many health-enhancing properties, most of which are relevant for the treatment of metabolic syndrome, including antioxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive effects. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation and prebiotic activity of other bioactive compounds present in foods. In addition, chlorogenic acid has antioxidant properties, especially against lipid oxidation. Protective properties against degradation of other bioactive compounds present in food and prebiotic activity. Methods: Molecular docking of COX2, NF-κB inducing kinase (NIK) & PhospholipaseA2 (PLA2) with chlorogenic acid was carried out by AutoDock. Result: The molecular docking result revealed that chlorogenic acid showed encouraging docking score. The docking score found to be -6.71, -6.31 & -4.43 kcal mol–1 respectively.
Are Economics Learning Outcomes Influenced by Learning Motivation and Active Learning?
Authors: Dwi Candra Fahrul Aditya Wahyu Hidayat  , Kamalia Putri Ulfa
Published: October 2022

Education aims to educate students to become human beings who are knowledgeable, creative, independent, capable, noble and responsible, these goals can be achieved with learning motivation and active learning in learning so that the learning outcomes obtained are good, especially in economic subjects. The purpose of this study was to determine 1) the partial effect of learning motivation variables on economic learning outcomes, 2) the effect of learning activities on economic learning outcomes, 3) the simultaneous influence of learning motivation variables and learning activities on economic learning outcomes in class X IPS SMAN 1 Cerme. The sampling method used was purposive sampling so that a sample of 86 students was obtained. This study uses primary data obtained from questionnaires. The results of this study indicate that there is a partially significant positive effect between learning motivation on economic learning outcomes, and there is a significant positive influence on learning activity variables on learning outcomes variables. Also simultaneously there is a significant positive effect between learning motivation and learning activity on economic learning outcomes and with an Adjusted R-squared value of 0.380 the contribution of the independent variable is 38%
Implementation of Teacher Certification in Improving the Quality of Education in MAN 1 Bogor Regency
Authors: Rini Nurbaiti Dwi Sulistiya
Published: October 2022

The teacher is a determining factor for the success and quality of learning. A learning that is not qualified can come from the low competence of a teacher and the teacher's inability to adjust the situation, that is what lowers the value of the quality of education in Indonesia. Due to the low quality of teachers, it will have an impact on the understanding and learning outcomes of students. Therefore, the government makes regulations for educators to have teacher certification in the hope that the quality of education in Indonesia can increase. The purpose of this study was to determine the implementation of teacher certification in improving the quality of education at MAN 1 Bogor Regency. In this study, the researcher used a field research approach and a type of qualitative method. From the results of this study, it can be concluded that implementing teacher certification is a real effort for MAN 1 Kab Bogor to improve the quality of education. Because with the provision of competent educators, they are able to provide good results on the quality of education.
Treatment Patterns of Follicular Lymphoma in the United States: A Claims Analysis
Authors: Huntington Scott , Appukkuttan Sreevalsa , Wang Wenyi , Du Yuxian , Hopson Sari , Babajanyan Svetlana
Published: October 2022

Background: A consensus is lacking on optimal treatment sequencing for follicular lymphoma (FL), the most common indolent lymphoma. FL is incurable, and many patients require multiple lines of therapy for successive relapses. Guidelines provide numerous recommendations for first-, second-, and third-line therapy; however, treatment patterns in the real world remain poorly understood. Objectives: The primary objective of this study is to evaluate real-world treatment patterns among commercially insured patients with FL in the United States. Methods: A retrospective cohort of patients with newly diagnosed FL was identified from June 2008 to September 2016 using the IBM MarketScan® database. Treatment pattern measures, including time to treatment from diagnosis, days from previous line of therapy, duration of therapy, and distribution of treatment regimens among lines of therapy, were assessed. Descriptive statistics were reported for baseline characteristics, primary outcome, and treatment pattern measures. Results: In total, 4232 patients were identified from the database and 2111 patients received at least 1 line of treatment. The most common first-line treatments included bendamustine + rituximab (39%), rituximab + cyclophosphamide + doxorubicin + vincristine (20%), and rituximab monotherapy (19%). Rituximab monotherapy was the most common second-line (34%) and third or greater line (57%) treatment. The median time from FL diagnosis to initiation of treatment was 50 days (interquartile range [IQR]: 28-191) for first-line treatment, 577 days (IQR: 312-1146) for second-line, and 776 days (IQR: 603-1290) for third-line. Discussion: At a median follow-up of 3.6 years, most patients had 1 or fewer lines of therapy. The use of combination therapy decreased with each line of therapy and the numbers of patients receiving third- or fourth-line therapy were small in this study, potentially due to the short follow-up. Rituximab as monotherapy or in combination was utilized most frequently; however, the variety of other therapies used demonstrates that the standard management of FL remains unclear. Conclusions: Consensus on optimal treatment sequencing is currently lacking, and patients receive a variety of active regimens during routine practice. In this contemporary cohort of patients diagnosed with FL in the United States, rituximab therapy predominated both in monotherapy and in combination.
PENENTUAN RUTE DISTRIBUSI MAKANAN RINGAN (SNACK) DENGAN METODE VEHICLE ROUTING PROBLEMS (Studi kasus pada UD. NNR JAYA di Bojonegoro)
Authors: Nugroho Rifqi Wahyu , Abdulrahim Musimin
Published: October 2022

UD. NNR Jaya merupakan usaha yang bergerak di bidang produksi makanan ringan yang memproduksi Mie Lidi, Makaroni, Kedelai di Desa Sumuragung, Kabupaten Bojonegoro. Pada penelitian ini penulis menentukan rute dengan menggunakan pendekatan algoritma sweep yang digunakan untuk mengelompokkan semua pelanggan kemudian membuat rute dari hasil tersebut (cluster) untuk mencari total jarak minimum menggunakan model matematika dengan konsep MILP (mixed integer linear programming ) menggunakan perangkat lunak Lingo 17.0x64. Yang digunakan untuk meminimalkan biaya dengan mencari rute terbaik tanpa melebihi kapasitas kendaraan yang ada, pendekatan model program linier integer campuran dapat menghemat biaya sebesar Rp. 368.707 atau hemat 5,46%. Sedangkan untuk jarak alternatif menghemat 5,42% dan menghemat waktu 4,51%.
Laminar separation bubbles on the transitional flow around airfoils
Authors: Montenegro- Montero Mariana , Richmond- Navarro Gustavo
Published: October 2022

The purpose of this work is to apply the γ-Re θ turbulence model, which is one of the numerical methods of shear stress transport (SST) applicable to transient flow, to examine if it shows the expected laminar separation cells or bubbles. This condition is key in the way to guarantee that the numerical modeling of lift and drag forces in aerodynamic profiles is more faithful to corresponding experimental data. For this, several two-dimensional simulations implemented with OpenFOAM, a well-known Finite Volume Method (FVM) package, were carried out for a Reynolds number range between 1x10 4 and 5x10 , with the airfoils NACA0012, SG6043 and S826, in which the laminar separation bubbles usually form. Numerical results of lift and drag coefficients show correct prediction of experimental results and error is reduced by 3% when compared to other simulations. In particular, adequate performance of the model is observed for regions close to or greater than the angle of attack for which the aerodynamic profile stalls. On the other hand, the geometric footprint of the flow simulated with this γ-Re 5 transition SST model shows great improvement compared to previous studies regarding the formation of laminar separation bubbles, which in turn means better performance when calculating lift and drag coefficients. It is also concluded that laminar separation occurs in the three studied airfoils, being symmetric or asymmetric profiles.
An IoT architecture for smart cities based on the FIWARE platform
Authors: Berbes Villalón Dalia M. , Sánchez Jiménez Laura , de la Iglesia Campos Manuel , Díaz Aguirre María E. , Delgado Fernández Tatiana
Published: October 2022

The Internet of Things (IoT) is a concept that has been gaining considerable popularity today. It attempts to represent everyday things that are connected to the internet, but in reality it is much more than that. The overall aim is to interconnect the physical with the digital world, as the physical world is measured by sensors which translates into actionable data, and also the data can be translated into commands to be executed by actuators.
Currently, the number of designed IoT architectures has increased considerably as a result of different approaches, standards and use cases. This leads to difficulties in understanding, selecting and using these architectures. In this work, an IoT architecture based on the FIWARE platform is proposed with the aim of facilitating the development of smart cities. With the proposal made, it was possible to integrate the main elements to be considered in this technology, thus offering a basis that serves as a guide, both for developing IoT systems and for creating more specific architectures that respond to the particular characteristics of a given application.
Urban Solid Waste Characterization of the Misiones Metropolitan Area
Authors: Sambiasi Cesar G. , Pascual Barrera Alina E. , Sambiasi Maria A.
Published: October 2022

This paper reports the behaviour of solid urban waste generation in the Metropolitan Area of Misiones, during a period of seven days. The waste analysed came from collection routes by household sampling points determined according to the land use and socioeconomic level of the population in the study area. The methodology consisted of visualising the sample universe, selecting the household waste collection routes and then classifying and analysing their composition according to ASTM D5231-92 (2016). This strategy was considered valid, given that the habits and customs of the population are closely related to the socioeconomic levels that directly affect consumption and consequently the quality of waste. Organic matter (51.80%) was the most representative, followed by materials with recycling potential, such as plastic (13.90%), glass (7.90%), paper and cardboard (7.80%), metals/aluminium (2.20%) and tetrabrik (2.60%). The quality of MSW was not uniform between cities, with Garupá (61.50%) being the city that generated the most organic waste, followed by Posadas (57.50%) and ending with Candelaria (29.00%) with a marked decrease. As a limitation of the method, it was determined that the results are representative of each city and of the winter season.
Extraction of Stevioside and Rebaudioside A from Stevia rebaudiana by percolation with ethanol-water solvents
Authors: Celaya Liliana , Ferreyra Darío , Kolb Eugenio , Kolb Koslobsky Nicolás
Published: October 2022

The aim of this study was to analyze the optimum temperature and percentage of ethanol to extract steviol glycosides (Stevioside and Rebaudioside A) from stevia leaves in a percolation extractor. The experiments were performed in broad ranges of binary solvent (0-100 % ethanol) and temperature (30–70 °C) in order to investigate their effects on steviol glycosides recovery and purity. The optimal extraction conditions, which gave a best steviol glycosides extraction kinetic were 70 °C and 35% of ethanol. In addition, the optimal extraction condition giving maximum purity was 70% of ethanol between 30 and 70°C.
Masa parotídea de rápido crecimiento, representando un dilema diagnóstico
Authors: Duque-Fisher Carlos Simón , Sánchez Erika Marcela , Martelo Alfredo , Hidron Alicia , Agudelo Miguel
Published: October 2022

La toxoplasmosis es una infección parasitaria con distribución mundial, cuyo huésped definitivo son los felinos. Se presenta con un cuadro clínico sintomático difuso solo en el 20 % de los pacientes inmunocompetentes. Además del malestar general,fiebre y adinamia, el hallazgo más importante lo constituye la presencia de adenopatías a nivel cervical. Describimos un caso poco común de un paciente masculino con masa parotídea izquierda de crecimiento rápido, en quien se practicó parotidectomía, a fin de descartar la enfermedad linfoproliferativa. Se comprobó compromiso porToxoplasma gondii luego de múltiples análisis.
Evaluation of Correlation between Diabetic Retinopathy and Hearing Impairment in Type 2 Diabetes Mellitus
Authors: Farooq Mashhood uz Zafar , Inamullah Syed , Mashhood Shama
Published: October 2022

Objective: Diabetic retinopathy is one of the leading causes of blindness that occurs secondary to diabetesmellitus. Besides having serious effects on the retina, diabetes has also been found to affect the hearing sense.The aim of our study was to identify any correlation of hearing impairment with diabetic retinopathy in patientssuffering from Type 2 diabetes mellitus.Study Design: A Retrospective study.Place and Duration of Study: The study was carried out at the outpatient Otorhinolaryngology andOphthalmology clinics of Mohsin Family Health Clinic, Federal B Area of Karachi, Pakistan, from July 2016 toJune 2019.Materials and Methods: Retrospective data analysis was performed using non-probability purposive sampling.The demographic data, diabetic retinopathy and Hearing status were collected and analyzed using SPSS 20.0 inpatients suffering from type 2 diabetes mellitus.Results: The mean age of patients was 60.65±7.35 and the duration of diabetes was 6.76±3.52. Diabeticretinopathy was evident in 235 patients (52.2%), and hearing impairment was found in 108(24%) patients. Age(p=0.024), duration of diabetes (p=<0.001), and diabetic retinopathy (p=<0.001) were significantly correlatedwith hearing impairment in type 2 DM patients.Conclusion: Hearing impairment is correlated with diabeticretinopathy in patients with type 2 diabetesmellitus. Monitoring of auditory function is advised in patients with retinopathy and vice versa, as timelymanagement of the condition can prevent further disability.

How to cite this: Farooq MZ, Inamullah S, Mashhood S. Evaluation of Correlation between Diabetic Retinopathy and Hearing Impairment in Type 2 Diabetes Mellitus. Life and Science. 2022; 3(4): 183-187 . doi: http://doi.org/10.37185/LnS.1.1.236
Neutralizing antibodies for SARS-CoV-2 infection
Authors: Berenguer Juan
Published: October 2022

The COVID-19 pandemic has boosted significant research in developing monoclonal antibodies (mAbs) to treat and prevent SARS-CoV-2 infection. Clinical trials have shown that mAbs are safe and effective in preventing hospitalization and death in patients with mild to moderate COVID-19 risk factors for progression. mAbs have also been effective for treating severe disease in seronegative patients and preventing COVID-19. So far, studies have been carried out in a largely unvaccinated population at a time when the omicron variant was not described. Future research should address these limitations and provide information on specific population groups, including immunosuppressed and previously infected individuals.
Current treatment of nosocomial pneumonia and ventilator-associated pneumonia
Authors: Plata-Menchaca Erika P. , Ferrer Ricard
Published: October 2022

Hospital-acquired pneumonia and ventilator-associated pneumonia are severe nosocomial infections leading to high morbidity and mortality. Broad-spectrum antibiotics with coverage against all likely pathogens are recommended by the international guidelines. Inappropriate empirical treatment is one of the most important prognostic factors. Knowledge of local epidemiology and continuous microbiological surveillance is crucial for improving clinical approaches to empirical antimicrobial treatment. The development of protocols and policies for training healthcare professionals on preventive strategies, such as the “Pneumonia Zero” project, and improved implementation of antimicrobial stewardship practices, will aid early de-escalation of antibiotics and prevent resistance.
Optimization of antimicrobial treatment in sepsis
Authors: Azanza Perea José Ramón
Published: October 2022

Sepsis represents a serious risk to the life of any patient, which is why it is crucial to start an effective treatment in all its extremes as soon as possible, that is, the chosen antibiotics must have activity against the pathogen that produces the condition and, in addition, they must be dosed considering the patient’s situation in all its extremes. It should be considered that it will be necessary to adjust the dose when there is edema (drugs with reduced volume of distribution), hypoproteinemia (drugs bound to proteins in a high proportion), obesity, and also when they require the use of external techniques such as ECMO or any of the different types of hemodialysis and hemofiltration.
Current management of CMV infection in cancer patients (solid tumors). Epidemiology and therapeutic strategies
Authors: García-Bustos Víctor , Salavert Miguel , Blanes Rosa , Cabañero Dafne , Blanes Marino
Published: October 2022

Little evidence is available regarding the incidence of CMV disease in patients with solid cancers. Latest data show that approximately 50 % of these patients with CMV PCR positivity developed clinically relevant CMV-viremia, and would require specific therapy. In the clinical arena, CMV reactivation is an important differential diagnosis in the infectological work up of these patients, but guidelines of management on this subject are not yet available. CMV reactivation should be considered during differential diagnosis for patients with a severe decline in lymphocyte counts when receiving chemoradiotherapy or immunochemotherapy with lymphocyte-depleting or blocking agents. Monitoring of CMV reactivation followed by the implementation of preemptive strategies or the establishment of early antiviral treatment improves the prognosis and reduces the morbidity and mortality of these patients.
Rapid techniques for therapeutic optimization. Diagnostic stewardship
Authors: Cercenado Emilia
Published: October 2022

Rapid microbiologic methods provide clinicians with information regarding the causative organisms of infections and their resistance to antimicrobials to optimize patient outcomes and antimicrobial use. Diagnostic stewardship requires that appropriate tests are requested and information is translated into appropriate management. The implementation of rapid techniques also provides collaborative opportunities between antimicrobial stewardship and diagnostic stewardship programs contributing to limiting the spread of antimicrobial resistance, and decreasing mortality, hospital length of stay, and healthcare costs.
Exhibition Event Evaluation Revisited: An Individual Value Approach
Authors: Mitchell Vincent Wayne , Makri Katerina , Schlegelmilch Bodo , Blaha Patrick
Published: October 2022

Studies looking at how millions of people attending exhibition events evaluate these events have identified many event characteristics. Using Means–End Chain Theory we categorize them into an overarching inputs–processes–outputs–outcomes model. Focusing on value-in-use as an end outcome, we devise a new measure of non-economic exhibition value using a multimethod set of studies. Study 1 uses qualitative interviews to identify the outcomes attendees value. Study 2 develops a scale for measuring the eight value dimensions, which include new values (e.g., inspirational value), unmeasured values (e.g., self-esteem), and underexplored values (e.g., social vs. relationship value). Study 3 deploys this scale across a series of exhibitions to predict 43%–61% of event satisfaction, loyalty, and word of mouth. The new model adds conceptual clarity to exhibition characteristics, and the new scale enhances the accountability and importance of exhibitions.
STRATEGIC ASPECTS OF RISK RESISTANCE MANAGEMENT OF A RETAIL ENTERPRISE
Authors: Grosul Victoria , Usova Marуna
Published: October 2022

Purpose. The aim of the article is substantiation of the methodology of strategic management of risk resistance of a retail enterprise.

Methodology of research. The works of domestic and foreign scientists on strategic risk management in the enterprise are the theoretical and methodological basis of the study. The tasks set in the work were solved using the following methods: analysis and generalization - when analysing models of strategic risk management; a systematic approach, an abstract and logical one - when determining the main stages of strategic management of the risk resistance of a retail enterprise, developing a “bow tie” diagram for assessing the risks of a retail enterprise; economic and mathematical modelling - when developing a tuple of structural elements of an information system for managing the risk resistance of a retail enterprise.

Findings. Scientific approaches to the formation of a strategic enterprise risk management system were studied. The key aspects of the methodology “Risk management of the organization. Integrated Model” were considered. A PPRR-model of strategic management of the risk resistance of a retail enterprise was developed. The main stages of strategic management of the risk resistance of a retail enterprise are determined. A tuple of structural elements of the information system for managing the risk resistance of a retail enterprise was formed. A methodical approach to the construction of a “bow tie” diagram for risk assessment of a retail enterprise is substantiated. This approach takes into account the relationship between the sources of risk and the consequences of its implementation.

Originality. An organizational and methodological approach to the formation of a strategic management system for the risk resistance of a retail enterprise has been developed, unlike existing ones, it creates the opportunity to quickly and timely respond to changes in the external environment, identify sources of risk, establish cause-and-effect relationships between risk factors and its consequences, analyse and prove relevant information at risk for strategic decision makers.

Practical value. Practical implementation of the results of the study lies in the development of applied tools that can be used to make informed strategic decisions to mitigate the consequences of the onset of risk events, increase the level of risk resistance of retail enterprises under resource and time constraints, while contributing to the achievement of the set targets for the activities of a trading enterprise.
Key words: risk, risk resistance, strategic management, PPRR model, information system, assessment, “bow tie” diagram.