bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFICACY OF PHACOEMULSIFICATION AND PHACOEMULSIFICATION COMBINED WITH GONIOSYNECHIALYSIS IN SURGICAL TREATMENT OF CHRONIC ANGLE-CLOSURE GLAUCOMA: 2-YEARS STUDY
Authors: Novytskyy Igor , Lopadchak Rostyslav
Published: November 2022

Aim. To study the degree of angle opening and the decrease of intraocular pressure in primary angle-closure glaucoma (PACG) after cataract phacoemulsification and cataract phacoemulsification with goniosynechialysis (phaco + GLS).

Materials and Methods. The study involved 28 patients (28 eyes) with primary chronic angle-closure glaucoma. The patients were divided into two groups, group 1 of 15 patients undergoing phaco with posterior chamber IOL implantation, and group 2 of 13 patients undergoing phaco with IOL implantation and GLS. The patients were followed for 24 months. Phaco was indicated in cases with IOP above 22 mmHg, appositional anterior chamber angle closure, and optic neuropathy; Phaco with GSL was indicated in cases of synechial angle closure and IOP above 22 mmHg

Results. In group 1 after Phaco, postoperative anterior chamber angle opening was >20° in all quadrants. Postoperative IOP after 24 month follow-up it decreased by 32,6 % from the preoperative levels. In group 2 after Phaco+GSL, anterior chamber angle opened at least to 20° in three or more quadrants in all cases. Postoperative IOP after 24 month follow-up it decreased by 33.0% from the preoperative levels.

Conclusions. Thus, phacoemulsification is an efficient procedure for PACG and appositional angle closure, leading to reopening of the anterior chamber angle with significant IOP reduction. Phacoemulsification alone does not lead to reopening of anterior chamber angle in cases with synechial angle closure, necessitating a combined surgery of phacoemulsification with GSL.
METHODICAL APPROACH TO THE DETERMINATION OF THE ANTIOXIDANT ACTIVITY OF THE ECHINACEA PURPUREA AND MONARDA FISTULOSA TINCTURES AS A QUALITY CRITERION OF THE DEVELOPMENT OF THEIR COMPOSITION AND LABORATORY TECHNOLOGY
Authors: Yezerska Oksana , Hudz Nataliia , Kobylinska Lesya , Filipska Anna , Turkina Vira , Brindza Jan , Wieczorek Piotr Pawel
Published: November 2022

Aim. The aim of the study was to develop the methodical approach to determine the antioxidant activity of the tinctures of Monarda fistulosa herb and flowers and roots of Echinacea purpurea, as well as to develop their technology in  laboratory conditions.

Materials and Methods. The following methods were used: analysis, synthesis, systematization, and comparison for processing of published scientific data on antioxidant activity; method for measuring the particle size of raw herbal materials; maceration and remaceration methods for obtaining the tested tinctures; DPPH test for the valuation of the antioxidant activity of the developed tinctures.

Results and Discussion.

The methodical approach to determining the antioxidant activity of the tinctures of Monarda fistulosa herb and flowers and roots of Echinacea purpurea was elaborated, the essence of which consisted in the selection of the appropriate dilution of the tinctures. Tinctures were prepared with the help of maceration or/and remaceration in laboratory conditions. The ratios of herbal raw materials (HRM) to the final tincture were close to ratios that are widely employed in the pharmaceutical industry, namely 1 to 5 and 1 to 10. The coefficients of alcohol absorption for the roots of Echinacea purpurea (size 2-5 mm), flowers of Echinacea purpurea (size 1-3 mm), herb of Monarda fistulosa (size 0.5-3 mm) were measured. They were measured as 1.2, 2.25, and 5.0 ml/g, respectively, for 70% ethanol. The studies revealed that Echinacea purpurea tinctures are a valuable source of antioxidant compounds. The antioxidant activity of these tinctures was 254.8-815.8 mg rutin-equivalents in 1 L of the tinctures or 1.12-4.43 mg rutin-equivalents in 1 g of the HRM depending on the part of the plant, particle size and extraction type. The antioxidant activity of the tinctures of the Monarda fistulosa herb was equal to 2203.6 mg eq-rutin/L and 20.3 mg eq-rutin/g for the tincture and HRM at a ratio of 1 to 9.5 and 2119.4 mg eq-rutin/L and 9.7 mg eq-rutin/g for the tincture at a ratio of 1 to 4.5.

Conclusions. The approach to the determination of the antioxidant activity of the tested tinctures was elaborated, namely the dilutions of the tinctures were established for the analytical procedure of the determination of the antioxidant activity. Our studies demonstrated that tinctures of Echinacea purpurea contained compounds with antioxidant activity. The tinctures of Monarda fistulosa herb are very rich in compounds with antioxidant properties. The laboratory technology of six tinctures was elaborated. Further studies will be directed at laboratory studies on microorganisms and animals.
CHROMATOGRAPHIC ANALYSIS OF CARBOXYLIC ACIDS IN THE FLOWERING SHOOTS OF SOME Vitex L. SPECIES
Authors: Shanaida Mariia , Holenko Alina
Published: November 2022

Introduction. The genus Vitex L. counts more than 200 species of shrubs and trees common to subtropical areas of the Earth. Only fruits of Vitex agnus-castus L. are used in official medicine.

The aim of our study was to perform the chromatographic analysis of carboxylic acids in the flowering shoots of three Vitex representatives under their cultivation in Ukraine.

Materials and Methods. Gas chromatography with mass spectrometry (GC/MS) was applied for the analysis of composition and contents of carboxylic acids in the Vitex agnus-castus L., Vitex negundo L. and Vitex negundo var. cannabifolia (Siebold & Zucc.) Hand.-Mazz. flowering shoots.

Results and Discussion. The Vitex agnus-castus raw material contained the most significant amount of short-chained aliphatic acids (2454 mg/kg). Malonic, oxalic, citric, and malic acids noticeably prevailed in all the raw materials. The largest amount of aromatic acids was found in the Vitex negundo var. cannabifolia (3926 mg/kg) flowering shoots. p-Hydroxybenzoic acid dominated among the aromatic acids in the plant raw materials of all species. The most noticeable total content of unsaturated fatty acids was in the Vitex negundo var. cannabifolia (4793 mg/kg).

Conclusions. To summarize the contents of valuable carboxylic acids, the obtained results provide the evidence for the development and further pharmacological study of herbal preparations from the flowering shoots of three Vitex species.
STRUCTURAL AND FUNCTIONAL CONDITION OF THE KNEE JOINT IN PATIENTS WITH MONOGONARTHROSIS IN THE STAGE OF EXACERBATION
Authors: Khanyk Taras
Published: November 2022

The goal is to study the structural changes of the elements of the knee joint and their functional consequences in patients with monogonarthrosis of the 1st-2nd grade in the stage of exacerbation according to the data of a complex clinical and arthroscopic study.

Materials and Methods. Materials - protocols of clinical, radiological and arthroscopic examination of 125 patients (54 (43.2%) men; 71 (57.8%) women), aged 18 - 79 years, with a previous diagnosis: Monoarthrosis of the knee joint in the stage of exacerbation. Research methods: questionnaire, orthopedic examination, X-ray diagnostics, arthroscopy, laboratory diagnostics of blood (determination of C-reactive protein (CRP) as a serological marker of inflammation), synovial fluid (analyses of physical properties, biochemical, cytological, bacteriological), statistical.

Results and Discussion. According to the results of the comprehensive examination, the presence of primary monoarthrosis was confirmed in 118 (94.4%) patients (group A). Based on the definition of CRP, subgroups were distinguished: A1 (n=71; 56.8%) with a normal level and A2 (n=47; 37.6%) with elevated CRP. In 7 (5.6%) patients diagnosed seropositive unspecified rheumatoid monoarthritis with hypertrophic synovitis (group B). A significant predominance of women compared to men insubgroup A2 was revealed (p<0.05). It was investigated that the features of complaints, nature of pain sensations and indicators of orthopedic status in patients from subgroups A1 and A2 did not reliably differ in groups of patients with different levels of CRP. A significant predominance of normal contours of the affected knee joint was found in subgroups A1 (p<0.001) and A2 (p<0.01). Structural changes in knee joint elements according to X-ray and arthroscopic examination have no significant differences in subgroups of patients A1 and A2.

Conclusions. The structural and functional state of the knee joints in patients with monogonarthrosis of the 1st-2nd grade according to the Kellgren-Lawrence classification is characterized by degenerative changes in almost all elements of the knee joint with moderate pain syndrome and functional disorders.
A retrospective analysis of surgical techniques and outcomes of hydatid disease in Wasit, Iraq
Authors: Qassid Al Harbawi Layth ,   Department of Anesthesiology, College of Medical Technology, AL-Kitab University, Kirkuk, Iraq,   Department of Surgery, College of Medicine, University of Nineveh, Nineveh, Iraq,   Layth Qassid Al Harbawi, Department of Surgery, College of Medicine, University of Nineveh, Nineveh, Iraq. E-mail: layth.q.alharbawi@uoalkitab.edu.iq, Kadhim Jawad Naseer ,   AL-Karama Teaching Hospital, College of Medicine, University of Wasit, Wasit, Iraq, Jawad AL-Dhahiry Kadhim ,   AL-Karama Teaching Hospital, College of Medicine, University of Wasit, Wasit, Iraq, Sakran Abass Kasim ,   Department of Pharmacology and Toxicology, College of Pharmacy, University of Kirkuk, Kirkuk, Iraq
Published: November 2022

Echinococcosis is a parasitic infestation with high prevalence in Iraq. Surgical treatment remains the standard gold method for treating this disease. The selection of surgical approach depends on the general condition of the patient and characters of the cyst, e.g., size, location, number of cysts, intraoperative findings, and complications such as adhesion, bile leakage, and bleeding. Our study aimed (1) to summarize the most common surgical approaches for treating liver hydatid cyst (HC) in our locality, and (2) to highlight common intraoperative and postoperative complications and the duration of hospital stay. We analyzed the clinical data of 42 patients operated for liver HC. We found that the highest incidence rate of HC was anatomically in the right hepatic lobe with or without synchronous cysts in other organs. The most frequent type of surgery was partial pericystectomy with external tube drainage (ETD) or simple endocystectomy with omentoplasty and ETD. The most important intraoperative finding was cystic-biliary communication. The majority of patients had uneventful postoperative recovery. There is no standardized surgical procedure for hepatic HC. The surgical technique should be modified according to the cyst size, anatomic location of cyst/cysts, number of cysts, cystobiliary communications, cystic infection, and the presence of extrahepatic hydatid cyst or cysts. The surgeon’s experience plays a vital role in selecting the surgical technique for hepatic hydatid cystectomy.
The role of cytokines, adhesion molecules, and toll-like receptors in atherosclerosis progression: the effect of Atorvastatin
Authors: Saud Ali ,   1 Department of Pharmacology and Therapeutics, College of Medicine, University of Kufa, Najaf, Iraq, Ali Nabeel AJ ,   2 Department of Pharmacology, College of Medicine, University of Basra, Basra, Iraq, Gali Fadil ,   1 Department of Pharmacology and Therapeutics, College of Medicine, University of Kufa, Najaf, Iraq, Hadi Najah ,   1 Department of Pharmacology and Therapeutics, College of Medicine, University of Kufa, Najaf, Iraq,   Najah Riesh Hadi, Department of Pharmacology and Therapeutics, College of Medicine, University of Kufa, Najaf, Iraq. E-mail: drnajahhadi@yahoo.com
Published: November 2022

Inflammatory cytokines, cell adhesion molecules, and toll-like receptors (TLRs) play an important role in atherosclerosis. The aim of this study was to further evaluate the role of inflammatory cytokines, cell adhesion molecules, and toll-like receptors in atherosclerosis. Forty local breed domestic male rabbits were divided randomly into 4 groups, 10 rabbits each. Group I was the control group, group II received a high cholesterol diet, group III received the drug solvent dimethyl sulfoxide (DMSO), and group IV received Atorvastatin (3.5 mg/kg/day). Blood samples were collected at 0 times, 5 weeks, and at the end of 10 weeks. TLRs expression on monocyte was measured by flow cytometry, IL-10, IL-17, IL-1β, intracellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) were measured by ELISA. In group II, a high cholesterol diet led to a statistically significant elevation of lipids profile (TC, TG, and LDL) at both 5 weeks and 10 weeks compared to the control. The expression of TLRs was also increased compared to the control (13.53±2.5 to 25.79±6.5). The intimal thickness increased from 103.46±13.85 to 248.43±11.11. IL-17 increased significantly from 3.4±0.4 to 7.7±1.00, and IL-1β increased from 1.04±0.19 to 9.66±1.4 (P 0.05) at 10 weeks. ICAM and VCAM increased from 1.7±0.16 to 8.2±0.74 and from 0.89±0.07 to 5.2±0.45, respectively. Atorvastatin significantly reduced TLRs at 10 weeks to 21.98±3.4 and intimal thickness to 191.6±15.59. IL-17, IL-1β, ICAM, and VCAM were significantly reduced by Atorvastatin. Cytokines, cellular adhesion molecules, and probably TLRs have a role in the pathogenesis of hyperlipidemia and atherosclerosis.
Vitamin D deficiency in young children with iron deficiency in Misan province, Iraq
Authors: Hashim AL-Zuhairy Salah ,   Department of Pediatrics, College of Medicine, University of Misan, Amarah, Iraq,   Salah Hashim AL-Zuhairy, Department of Pediatrics, College of Medicine, University of Misan, Amarah, Iraq. E-mail: salahalzuhairy@uomisan.edu.iq, Abed Darweesh Mohammed ,   Department of Pediatrics, College of Medicine, University of Misan, Amarah, Iraq, Abdul-Mounther Othman Mohammed ,   Department of Biochemistry, College of Medicine, University of Misan, Amarah, Iraq, AL-Huda Salah AL-Zuhairy Noor ,   Department of Pharmacy, Al-Manara College for Medical Sciences, Amara, Iraq
Published: November 2022

This study aimed to assess vitamin D status and its association with iron status in young Iraqi children. A total of 95 infants and toddlers with iron deficiency (ages ranging from 6 to 24 months) and an equal number of 95 healthy subjects with normal hemoglobin (Hb) and sufficient ferritin level with matching age were included as a control group. A specially designed questionnaire was used to collect data. The cases were classified into iron deficiency (ID) and iron deficiency anemia (IDA) according to hemoglobin and ferritin levels. The cases and control groups were subdivided into vitamin insufficiency (VDI), vitamin D deficiency (VDD), and vitamin D sufficiency groups according to 25-hydroxyvitamin D [25(OH)D] levels. Young children with IDA have significantly lower serum levels of 25(OH) D compared with ID and control groups (p<0.05). According to iron status, VDI and VDD were present in 20% and 70% of IDA, 25.7% and 60%of ID, and 26.3% and 30.5% of control groups, respectively, with a significant difference in vitamin D level (p<0.05) among studied groups. A significant positive correlation (p=0.000) was found between serum ferritin level and 25(OH) D level in studied patients. Young children with severe iron deficiency have a higher prevalence of vitamin D deficiency, and there was a significant positive correlation between serum ferritin level and 25(OH) D levels among studied children.
Comparison of TNF-α and IL-19 concentrations at different stages of breast cancer
Authors: Mohammed Amera Kamal ,   1 Clinical Laboratory Sciences Department, College of Pharmacy, University of Kirkuk, Kirkuk, Iraq,   Amera Kamal Mohammed, Clinical Laboratory Sciences Department, College of Pharmacy, University of Kirkuk, Kirkuk, Iraq. E-mail: dr.amera.k@uokirkuk.edu.iq
Published: November 2022

This study investigated the alteration of tumour necrosis factor (TNF-α) and interleukin-19 (IL-19) at different clinical disease stages, lymph node metastasis, and ductal carcinoma in women with breast cancer. Serum samples were collected from 90 individuals with an age range of 25–61 years. These individuals were divided into a control group (healthy people), consisting of 31 individuals, and a breast cancer patients (BCP) group, consisting of 59 individuals. The pathological data (tumour stage, lymph node metastasis, and ductal carcinoma) was obtained from the medical record of patients and confirmed by experienced histopathology. Enzyme-linked immunosorbent assay (ELISAs) technology was used to measure the serum concentrations of IL-19 and TNF-α. The results showed significant differences (P≤0.002) in the mean of BMI, interleukin-19, and TNF-α in BCP compared to controls, while the age factor did not play an important role. The stages of breast cancer caused clear differences in the levels of TNF-α and IL-19. According to the findings, BCPs had a greater level of TNF-α in lymph node metastases than healthy persons. The concentration of serum IL-19 in BCP with lymph node metastasis was significantly different in non-lymph node metastasis patients and healthy people. Additionally, BCP with ductal carcinoma showed significant differences in the mean levels of IL-19 and TNF-α in comparison with healthy people.
Perception and attitudes of dentists regarding the complications of conventional acrylic dentures and overdentures supported by teeth or implants
Authors: Teodorescu Cristian ,   Department of Complete Denture, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Cristian Teodorescu, Department of Complete Denture, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. E-mail: cristian.teodorescu@drd.umfcd.ro, Preoteasa Elena ,   Department of Complete Denture, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Preoteasa Cristina Teodora ,   Department of Scientific Research Methods-Ergonomics, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Murariu-Măgureanu Cătălina ,   Department of Complete Denture, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Teodorescu Ioana Monica ,   Department of Complete Denture, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

This study aimed to assess the perception of dentists on the complications associated with prosthodontic treatments with acrylic dentures and overdentures in partially or complete edentulous patients. The study analyzed the complications of acrylic dentures and overdentures using a questionnaire with 24 open or closed questions, with single or multiple answers. The participants were 63 dentists, mostly women (77.8%), aged between 30 and 39 years old (52.4%), more than half of them with a clinical experience of less than 15 years. The main complications encountered were: lesions of the oral mucosa (52.4%), lack of maintenance (44.4%) or stability of dentures (39.7%), fracture of acrylic bases (14.3%), and detachment of attachment systems (44.4%). The complete maxillary acrylic dentures fractured most often (38.1%), frequently on the midline (58.7%), the main causes being accidental fall, masticatory stress, or lack of stability of the dentures. The most common intervention to correct the complications of dentures was the repair of fractured acrylic bases (33.3%). The study exposed that dentists are aware of the possible complications of acrylic dentures, which they correlate with the peculiarities of oral structures, but also with some deficiencies of prosthodontic restorations, materials and technologies. Maxillary acrylic dentures, overdentures, and partial acrylic dentures have a high risk and fracture rate, but the use of new technologies and materials can reduce the complications rate of acrylic dentures and overdentures.
Vocal fold injury models in rats: a literature review on techniques and methodology
Authors: Laszlo Ujvary Peter ,   Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Maria Blebea Cristina ,   Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Cristina Maria Blebea, Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. E-mail: cristina_blebea@yahoo.com, Aurelia Maniu Alma ,   Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Pop Sever ,   Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Sarpataki Orsolya ,   Department of Physiology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania, Cosgarea Marcel ,   Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: November 2022

This study reviewed the current literature on technical aspects regarding controlled vocal fold injuries in the rat model. Data from PubMed, Embase, and Scopus database for English language literature was collected to identify methodological steps leading to a controlled surgical injury of the rat vocal fold. Inclusion criteria: full disclosure of anesthesia protocol, positioning of the rat for surgery, vocal fold visualization method, instrumentation for vocal fold injury, vocal fold injury type. Articles with partial contribution were evaluated and separately included due to the limited number of original methodologies. 724 articles were screened, and eleven articles were included in the analysis. Anesthesia: ketamine hydrochloride and xylazine hydrochloride varied in dose from 45 mg/kg and 4.5 mg/kg to 100 mg/kg and 10 mg/kg. Visualization: The preferred method was the 1.9 mm, 25–30 degree endoscopes. The widest diameter endoscope used was 2.7 mm with a 0 or 30 degree angle of view. Instruments for lesion induction range from 18 to 31G needles, microscissors, micro forceps to potassium titanyl phosphate, and blue light lasers. Injury types: vocal fold stripping was the main injury type, followed by vocal fold scarring and charring. One article describes scaffold implantation with injury to the superior aspect of the vocal fold. Rats are good candidates for in vivo larynx and vocal folds research. A more standardized approach should be considered regarding the type of vocal fold injury to ease data comparison.
Repetitive transcranial magnetic stimulation (rTMS) as a therapeutic option in paraneoplastic cerebellar ataxia – a case report
Authors: Jemna Nicoleta ,   1 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   Nicoleta Jemna, RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania. E-mail: nicoleta.jemna@ssnn.ro, Zdrenghea Ana Calina ,   1 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   2 Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Frunza Georgiana ,   1 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   2 Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Demea Anca ,   1 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   2 Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Muresanu Dafin Fior ,   1 RoNeuro Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania,   2 Department of Neurosciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: November 2022

Paraneoplastic cerebellar ataxia is a paraneoplastic neurological syndrome (PNS) that can be the first clinical manifestation of underlying cancer. It is usually associated with onco-neuronal antibodies and has no other specific paraclinical feature. After the surgical and oncologic treatment of the primary cancer, the remaining neurological symptoms have limited therapeutic options. We describe a case of severe ataxia as the primary manifestation of ovarian cancer, with a significant clinical and paraclinical improvement of the neurological symptoms after 20 sessions of rTMS intervention.
Síndrome alcoólica fetal no contexto de pós-pandemia da COVID-19
Authors: Silva Maria Letícia Santos Carnaúba da , Magnabosco Amanda Rodrigues dos Santos , Cadena Pabyton Gonçalves
Published: November 2022

Objetivo: Traçar relação entre as consequências secundárias do pós-pandemia da COVID-19 e fatores de risco para o desenvolvimento dos transtornos do espectro alcoólico fetal (TEAF) e da síndrome alcoólica fetal (SAF). Revisão bibliográfica: No contexto atual de pós-pandemia é correto afirmar que houve um crescimento de alguns dos principais fatores que influenciam em um maior risco do desenvolvimento do TEAF. Dentre eles se tem um aumento do estresse e da ansiedade, que empobreceram a saúde mental e aumentaram o consumo de álcool, as taxas de desemprego aumentaram a insegurança alimentar e o impacto nos serviços de saúde diminuíram a realização de serviços básicos. Todos esses fatores já existiam, mas foram exacerbados pela pandemia, podendo ser considerados consequências secundárias dela. Considerações finais: A pandemia da COVID-19 certamente trouxe maior dificuldade para as gestações e aumentou fatores associados ao desenvolvimento de agravos do desenvolvimento como o TEAF e a SAF. Pesquisas a respeito da relação desses fatores, em contexto de pós-pandemia, relacionados a um crescimento de casos do TEAF e da SAF ainda são escassas, embora a relação exista. Isso deve ser avaliado, pois estes são agravos que comprometem permanentemente a vida das pessoas afetadas, mas são previsíveis e evitáveis.
Metodologias ativas no processo de educação permanente: experiência do Curso Especialização em Saúde Pública
Authors: Sant' Ana Leila Auxiliadora José de , Jerônimo Eliane Barbosa
Published: November 2022

Objetivo: Analisar os resultados do Curso de Especialização em Saúde Pública, na prática profissional dos egressos dos anos 2016 e 2017 da Escola de Saúde Pública do Mato Grosso. Métodos: Pesquisa qualitativa, desenvolvida com egressos do curso de pós-graduação em Saúde Pública, de forma avaliativa, utilizou-se do questionário estruturado em variáveis socioeconômicas, práticas profissionais e, resultados do curso. Participaram da pesquisa egressos certificados das turmas ofertadas; que aceitaram participar voluntariamente e concordaram com o Termo de Consentimento Livre e Esclarecido. Resultados: A maioria é mulher (81,25%), formação em enfermagem (31,25%), Serviço Social (18,74%), Odontologia (15,62%) e com outra pós-graduação (59,38%), trabalha em órgãos municipais e estadual (59,09%), continua na mesma função (56,24%), não atua com o mesmo gestor (90,62%) e nem mesma equipe (59,37%). Considerações finais: O estudo mostrou que, embora com outra pós-graduação, os profissionais mostraram interesse na saúde pública. A metodologia do curso se dá na relação ensino-serviço, direcionado às reflexões e ações das necessidades locais, proporcionando contribuições para melhoria dos processos de trabalho no fazer e atitude professional.  O estudo poderá subsidiar no processo de avaliação, de propostas e estratégias na implementação da política de educação permanente no Mato Grosso
A influência do exercício físico sob o estresse oxidativo em idosos: uma revisão narrativa
Authors: Silva Everton Claudio da , Silva Antônio Paulo Nunes Azevedo da , Malta Weslan Vieira , Lima Bruno Basílio Cardoso de , Gomes Aline da Silva , Cavalcanti Pablo Renato José Lima , Silva Maria Clara da , Lira Miriam Cibele de , Ferreira Erik Henrique de Melo
Published: November 2022

Objetivo: Discorrer sobre a prática de exercícios físicos realizados por idosos e sua influência no estresse oxidativo. Revisão bibliográfica: Dependendo da modalidade do exercício físico, bem como a frequência em que é praticado, intensidade da sessão de treinamento, via energética predominante, entre outros, o sistema antioxidante é influenciado de maneira positiva, impactando diretamente na produção de Espécies Reativas de Oxigênio (EROs), e em biomarcadores de estresse oxidativo, como a peroxidação lipídica e na produção e expressão de proteínas atreladas ao estresse oxidativo em indivíduos idosos, levando-se em consideração a individualidade biológica, hábitos alimentares e a qualidade do sono. Considerações Finais: O exercício físico impacta de forma positiva no sistema antioxidante indicando que em algumas modalidades de exercício existe o aumento de enzimas que pertencem ao sistema antioxidante como catalase (CAT), Superóxido Dismutase (SOD) dentre outras, que intervêm no estresse oxidativo em idosos. Entretanto, são necessários mais estudos aprofundados que se voltem de forma específica para abordar essa temática.
Câncer de mama triplo negativo: avanços e perspectivas nos aspectos epidemiológicos, clínicos e terapêuticos
Authors: Gusmão Letícia Cruz , Rocha Thaiala Silva , Luz Nicolly Barbosa Neves , Freitas Aline Reis , Oliveira Gabriel Lédo Pereira de
Published: November 2022

Objetivo: Analisar os avanços e perspectivas dos aspectos epidemiológicos, clínicos e terapêuticos do Câncer de Mama Triplo Negativo (CMTN). Métodos: Trata-se de uma revisão integrativa da literatura, entre 2017-2021, a partir das bases de dados PubMed, SciELO e LILACS por meio de descritores nos idiomas português, inglês e espanhol, com texto completo disponível. Foram identificados 801 artigos, destes, 366 artigos obedeceram aos critérios de inclusão e exclusão. Após leitura e análise crítica, foram elegidos 35 artigos para o universo amostral desta revisão. Resultados:  O tratamento padrão atual para o CMTN inicial baseia-se em quimioterapias principalmente a base de antraciclinas e taxanos, inibidores da Poli (adp-ribose) Polimerase (PARP) para mulheres com CMTN Metastático (mCMTN) com mutação do Breast Cancer Gene (BRCA) e uso de imunoterapias. No entanto, novas propostas inovadoras surgiram, como vacinas, biomarcadores inéditos e terapias antiangiogênicas que ainda estão em desenvolvimento. A prevalência desse tipo neoplásico foi maior em mulheres com faixa etária em torno de 50 anos; raça negra; com presença da mutação BRCA1. Considerações finais: Constatou-se que apesar de alguns estudos trazerem propostas com ganhos relevantes (>10 meses) em Sobrevida Global (SG), ainda se faz necessário alcançar novos avanços em aspectos clínicos e terapêuticos no CMTN.
Abscesso cerebral como manifestação de neoplasia cerebral: relato de caso
Authors: Souza Bruna Lyandra Portela Sena de , Freitas Juliana Barroso de , Silva Soraya Souto da , Cruz Ketllyn de Oliveira , Coriat Junior Apaestegui , Queiroz Ann Karla Corrêa , Carneiro Bárbara Seabra , Oliveira Tamiris Silva de , Teixeira Carlos Eduardo Garcez , Oliveira Filho Wilson de
Published: November 2022

Objetivo: Relatar um caso clínico de uma paciente que apresentou abscesso cerebral secundário à presença de uma neoplasia cerebral. Detalhamento de caso: Paciente do sexo feminino, com 50 anos, foi admitida em Hospital Universitário, com histórico de cefaleia diária, com início há 3 semanas, de caráter progressivo, que não cedia com uso de sintomáticos. O quadro evoluiu com perda de força, parestesia, paralisia facial e prejuízo da fala. Foi realizada tomografia computadorizada do crânio que revelou lesão circunscrita com edema perilesional em região temporoparietal esquerda. Em cirurgia para biópsia da lesão constatou-se a presença de abscesso, sendo drenado. Comprovada neoplasia pelo resultado da biópsia, a paciente foi encaminhada para tratamento em centro especializado em oncologia do Estado. Considerações finais: O acompanhamento do presente caso mostrou-se interessante por sua raridade, tendo em vista a presença do abscesso em decorrência da existência de uma neoplasia no mesmo local, sendo uma ocorrência dificilmente encontrada na literatura, principalmente devido ao fato de a bactéria colonizadora ser o Staphylococcus aureus, que é uma bactéria da pele.
Qualidade de vida, após operação de Fontan, em crianças e adolescentes portadores de cardiopatias congênitas
Authors: Camargo Matheus Pileggi , Marchi Carlos Henrique de , Godoy Moacir Fernandes de , Barufi Alexandra Regina Siscar , Avona Fabiana Nakamura , Bodini André Luis de Andrade , Policarpo Rafael da Silva , Borim Bruna Cury , Croti Ulisses Alexandre
Published: November 2022

Objetivo: Avaliar a qualidade de vida de crianças e adolescentes portadores de cardiopatias congênitas com fisiologia univentricular após operação de Fontan. Métodos: Aplicado o módulo cardíaco do questionário Pediatric Quality of Life Inventory TM (PedsQLTM 3.0) em indivíduos de 8 a 18 anos e que haviam realizado a operação de Fontan. Realizada análise estatística descritiva e inferencial utilizando-se dos testes exato de Fisher, t não pareado e Mann-Whitney. Admitiu-se erro alfa de 5%. Resultados: O questionário foi aplicado em 10 indivíduos com a operação de Fontan e em 27 sem cardiopatia (grupo controle). A média de idade geral foi de 12,7 anos. Foi detectada qualidade de vida reduzida de forma geral no grupo Fontan em relação ao controle. Destaque para o eixo que avaliou autoimagem e aparência perante a sociedade na qual obteve-se notas muito próximas e, em alguns critérios, até maiores para o grupo Controle. Também relevante o excesso no uso de anticoagulantes de difícil manejo no grupo Fontan. Conclusão: A qualidade de vida das crianças e adolescentes portadoras de cardiopatias congênitas de fisiologia univentricular após operação de Fontan mostrou-se reduzida e as medidas a nível multidisciplinar podem ser aperfeiçoadas a fim de impactar positivamente de uma forma geral.
Idosos que cuidam de seus idosos na família
Authors: Garcia Deomara Cristina Damasceno , Piveli Maria Lúcia Silveira Batista , Corrente José Eduardo , Jacinto Alessandro Ferrari
Published: November 2022

Objetivo: Analisar os resultados do acompanhamento psicológico, pela escuta psicanalítica, de idosos que cuidam de familiares idosos. Métodos: Intervenção e acompanhamento psicológicos individuais oferecidos a 51 idosos familiares que cuidam de idosos. Resultados: Dos 51, apenas cinco idosas cuidadoras (65-79 anos) demonstraram interesse no acompanhamento psicológico. Essas idosas cuidam dos maridos (68-85 anos) ou de suas mães (90-95 anos). Buscamos uma reflexão quanto às idosas ficarem na posição de submissão, de reclamações, de sofrimentos trazidos em seus discursos, com relação às desvantagens advindas do cuidar de dependentes exigentes, autoritários ou controladores. Identificamos que, inconscientemente, havia um algo a mais e, propusemos a ideia do “avantajamento”, que se refere a um processo inconsciente do idoso cuidador de reconhecer-se numa posição vantajosa frente ao familiar dependente. Conclusão: O acompanhamento psicológico das idosas cuidadoras possibilitou, por meio de uma escuta diferenciada, estímulo à implicação em seus sintomas e, inclusive, no propósito do cuidar. Com a abertura dessa chave inconsciente e da continuidade no processo analítico, cada idosa caminhou na busca de um reinvestimento em si e numa nova relação com o outro; de permitir-se ser um sujeito, que tem desejos, e não somente um idoso que cuida.
FINER criteria – What does it mean?
Authors: Mohanan Saritha , Parameswaran Narayanan
Published: November 2022

The formulation of a research question in the appropriate scientific “syntax” is one of the vital steps in preparing a research proposal. Every research question should ideally have certain essential attributes which are represented by the FINER acronym. FINER stands for feasible, interesting, novel, ethical, and relevant. Ensuring that his/ her research question meets these attributes is useful to the investigator, especially for those starting out in their research career. This article is a brief overview of these attributes which may assist an investigator to strengthen his/her research plan or idea.
Öğrenci Toplulukları Üyelerinin Boş Zaman Tutumları ve Örgütsel Bağlılıklarının İncelenmesi
Authors: KAYA Cengiz , EKİCİ Sümmani , ÖNTÜRK Yavuz
Published: November 2022

Bu araştırma, öğrenci toplulukları üyesi öğrencilerin boş zaman tutumları ve örgütsel bağlılıklarını belirlemek amacı taşımaktadır. Araştırmanın çalışma evrenini, Muğla Sıtkı Koçman Üniversitesi öğrenci topluluklarına bağlı üye öğrenciler oluşturmaktadır. Örneklem grubunu ise, araştırma evreni içerisinden gönüllü katılım sağlayan 362 üye öğrenci oluşturmaktadır. Veri toplama aracı olarak, kişisel bilgi formu, Akgül ve Gürbüz (2011) tarafından Türkçe uyarlaması yapılan “Boş Zaman Tutum Ölçeği” ile Ergün ve Çelik (2019) tarafından Türkçe uyarlaması yapılan “Örgütsel Bağlılık Ölçeği” kullanılmıştır. Araştırmada, iki bağımsız değişken arasındaki farkın ortaya konmasında T-Testi ve ikiden fazla değişkenler arası farkın belirlenmesinde ise One-Way ANOVA testleri yapılmıştır. Ayrıca değişkenler arasındaki ilişkinin belirlenmesinde ise Korelasyon testi kullanılmıştır. Araştırmada elde edilen bulgulara göre, kadınların erkeklere göre bilişsel tutum alt boyut puanının daha yüksek olduğu görülmektedir. Sağlık bilimleri alanında öğrenim gören öğrencilerin fen bilimlerinde öğrenim gören öğrencilere göre bilişsel tutum alt boyut puanının daha yüksek olduğu tespit edilmiştir. Araştırmaya katılan erkek üyelerin kadın üyelere göre zoraki bağlılıklarının daha yüksek olduğu görülmektedir. Üye öğrencilerin boş zamana yönelik tutumları bilişsel, duyuşsal ve davranışsal alt boyutlar ile örgütsel bağlılık alt boyutlarından çıkarcı ve ahlaki alt boyut ile pozitif yönde ilişki görülürken, bilişsel ve duyuşsal alt boyut ile zoraki bağlılık alt boyutunda ise negatif yönde ilişki tespit edilmiştir. Sonuç olarak, öğrenci topluluklarına katılarak faaliyette bulunan öğrencilerin üniversite eğitimi ve öğretimi döneminde boş zamana yönelik farkındalıklarının arttığı, kişisel gelişim, sosyalleşme ve gönüllülük faaliyetlerine yönelmelerine katkı sağladığı söylenebilir.
Alt ve Üst Gövde Statik Germe Egzersizlerinin Postüral Kontrole Etkisi
Authors: KOCAOĞLU Yağmur , ÇALIŞKAN Ömer , ARGUZ Abdullah , KORKUSUZ Furkan , OĞUZ Ahmet Gürsel , ERKMEN Nurtekin
Published: November 2022

Bu araştırmada 11-13 yaş basketbolcularda üst gövde, alt gövde ve tüm gövdeye uygulanan statik germe egzersizlerinin postüral kontrole etkisini tespit etmek amaçlandı. Çalışmaya yaş ortalaması 11,44 ± 0,89 yıl, boy uzunluğu 158,25 ± 7,79 cm, vücut ağırlığı 54,19 ± 12,30 kg ve spor deneyimi 2,34 ± 1,17 yıl olan 16 erkek basketbol oyuncusu gönüllü olarak dahil edildi. Katılımcılar farklı günlerde 4 ayrı deney koşulunda araştırmaya dahil edildi: 1) Üst Gövde Germe Egzersiz Grubu (ÜGGE), 2) Alt Gövde Germe Egzersiz Grubu (AGGE), 3) Karışık Germe Egzersiz Grubu (KGE), 4) Kontrol Grubu (K). Rastgele olarak çalışma koşullarına dahil edilen katılımcılar her biri 30 sn süren ve aralarında 15 sn dinlenme verilen statik germe egzersizlerini yaklaşık 12 dk uyguladılar. Statik germe egzersizleri öncesi ve sonrasında postüral kontrol ölçümleri Denge Hata Puanlama Sistemi (DHPS) kullanılarak gerçekleştirildi. Köpük zemin DHPS puanları hem ön testte hem de son testte gruplar arasında anlamlı düzeyde farklı değildi (p>0,05). Köpük zemin ÜGGE ön test – son test fark puanları AGGE’den yüksekti, KGE fark puanları ise AGGE’den ve Kontrol grubundan daha yüksekti (p<0,05). Köpük zeminde ÜGGE, AGGE ve K gruplarının ön test – son test karşılaştırmalarında anlamlı farklılık bulunmadı (p>0,05), ancak KGE son test DHPS puanları ön testten daha düşüktü (p<0,05). Toplam DHPS puanları incelendiğinde; ön testte, son testte ve fark puanlarının araştırma grupları arasında anlamlı düzeyde farklı olmadığı bulundu (p>0,05). ÜGGE, AGGE ve K gruplarının ön test – son test toplam DHPS puanlarında farklılık görülmezken (p>0,05) KGE’nin toplam DHPS puanlarının son testte anlamlı düzeyde azaldığı tespit edildi (p<0,05). Sonuç olarak; üst ve alt vücuda yönelik statik germe egzersizleri postüral kontrolü etkilemedi, buna karşın tüm vücuda yönelik statik germe egzersizleri postüral salımın performansını artırdı.
Optimization of vitamin c extraction of roselle petals (Hibiscus sabdariffa)
assisted with microwaves using response surface methodology
Authors: Purbowati I.S.M. , Maksum A. , Ritonga A.M. , Kurniawan R.E.K.
Published: November 2022

Vitamin C contained in roselle petals acts as an antioxidant that provides health benefits.
In order to make it easier to use, vitamin C needs to be extracted out of the roselle petal
cells in the form of extracted raw roselle juice. The commonly used conventional method
has disadvantages that can damage heat-sensitive compounds such as vitamin C. An
alternative extraction method used was microwave-assisted extraction. The success of this
method in extracting vitamin C was influenced by a few factors, such as the ratio of the
roselle petals-water, microwave power, and extraction time. The purpose of this study was
to determine the optimum conditions for microwave-assisted extraction of vitamin C in
roselle extract and to determine the physical and chemical characteristics of roselle extract
produced in the optimum conditions. This study utilized response surface methodology
(RSM) in a central composite design (CCD). The optimized factors included the roselle
petals-water ratio (5 - 10%), microwave power (150 - 350 W), and extraction time (3 - 7
mins). The parameter response tested in this study was vitamin C. While the extract
produced under optimum conditions was also characterized by the total anthocyanin
content, total phenols, antioxidant activity, pH value and colour (L, a* and b*). The results
showed that the recommended optimum conditions were a 5% roselle petals-water ratio,
250 W of microwave power, and 6.09 mins of extraction time. The verification results
show that this optimum condition produced vitamin C higher than the conventional
method. The characteristics of roselle extract produced by microwave-assisted extraction
at optimum conditions were vitamin C at 9.973±0.508 mg/g, total anthocyanins at
1.771±0.124 mg/100 g, phenol at 30.848±1;899 m/g, IC50 at 6.699±0.627 ppm, pH at
2.133±0.057, colour with an L value of 31.033±0.404, a* value of 1.066±0.155, and b*
value of 18.100±0.458.
Effects of roasted defatted sesame seed (Sesamum indicum) flour addition on the
nutritional quality, dietary fibre, and glycaemic index of malted amaranth grain
(Amaranthus hybridus) flour
Authors: Ogundele O.M. , Ojedokun F.O. , Fasogbon B.M. , Bamidele O.P.
Published: November 2022

This study determined the effects of the addition of roasted defatted sesame seed flour to
malted amaranth flour at different ratios on the nutritional quality, dietary fibre, and
glycaemic index of composite flour. The proximate composition of the composite flour
increased with an increase in the percentage of roasted sesame seed flour added. Although
the amino acid profile of the flour blends did not significantly change in the composite
flour, the pasting properties were significantly reduced with the addition of roasted
defatted sesame flour. The dietary fibre increased with the addition of roasted defatted
sesame seed flour and the estimated glycaemic index was significantly reduced. The
composite flour containing 50% malted amaranth flour and 50% roasted defatted sesame
seed flour has the lowest glycaemic index. The addition of roasted defatted sesame flour
to malted amaranth flour up to 50% may be good raw material in further processing of
flour for complementary or breakfast foods.
The effect of high protein milk supplementation on satiety in normal weight
subjects
Authors: Muliadi R.D. , Kartawidjaja F. , Antono L.
Published: November 2022

Obesity has become a serious problem in the world. Protein is known for giving higher
satiety rather than other macronutrients. However, most studies conducted their research
on, either overweight or obese subjects, whereas the satiety response might be different.
The objective of the study was to evaluate the effect of high protein milk (HPM)
supplementation on self-reported satiety and energy intake in healthy adult men with
normal BMI (18.5 – 22.9 kg/m2
). In a controlled single-blind cross-over study, 17 healthy
adult men (age 27±5 years; BMI 21.4±1.13 kg/m2
) attended 2 sessions 1 week apart. In
each session, all participants consumed a drink of 200 mL HPM (12 g protein, 2.5 g fat,
12 g carbohydrate, 120 kcal) or standard protein milk (SPM) (4g protein, 2.5 g fat, 20 g
carbohydrate, 120 kcal) together with standardized breakfast±4 hours before ad libitum
lunch. The result showed that fullness and hunger ratings were significantly greater on
HPM supplementation than SPM (P = 0.031, P = 0.043, respectively). However, there was
no significant effect on the rating of the desire to eat (P = 0.123) and energy intake during
lunch (P = 0.926). The results support the hypothesis that supplementation of HPM could
improve satiety in healthy adult men with normal BMI.
Curriculum Advisors’ and Teachers’ Perceptions of Teaching Reading in Foundation Phase Classrooms
Authors: Khosa Martha
Published: November 2022

This article aims to examine curriculum advisors’ and teachers’ perceptions of teaching early reading in Foundation Phase classrooms. It also aims to provide recommendations to alleviate overlaps based on the findings. A qualitative approach was used to gather data through semi-structured interviews. Purposeful convenience sampling was used to study two curriculum advisors and five Grade 1 teachers from five schools in the Mopani district of Limpopo Province. Data collected were analysed using thematic analysis. The findings showed that the curriculum advisors and teachers vary in their perceptions of early reading. Both curriculum advisors perceived that teachers change slowly, teach early reading unsystematically, and show superficial compliance, but do not really abide by guidelines, while teachers say the National Curriculum does not give them enough time to teach properly or attend to struggling learners. Teachers also expressed their frustration in managing large classes. This research article contributes to the body of knowledge in creating an awareness that new curriculum requirements are tools used for aligning teachers with change.
A Case Study on the Impact of Digital Relationships on Unaccompanied Minors during the COVID-19 Lockdown
Authors: Coin Francesca , Banzato Monica
Published: November 2022

The exploratory study investigates how unaccompanied minors (UAMs) in Italy dealt with social isolation at the time of the outbreak of the COVID-19 pandemic. Have they suffered from the effects of the lockdown? How did their relationships change? What feelings characterised their experience? What factors helped them? Did ICT help them, or did it increase their social and economic marginalisation? Very little research has investigated the issues of UAMs, socialisation, technologies, and pandemics together. The data were collected through a purpose-built questionnaire that obtained an excellent Cronbach Alpha index (0.91) for internal consistency, which was administered to the migrant students of a school in North-East Italy. The answers indicated that they perceived the change in their social relations; but they coped with it, thanks to their internal resources, such as resilience and self-efficacy, and external ones, including digital devices and social support from family and teachers. Their friendship networks are regrettably fragile, and the youths do not rely much on them. On the other hand, the results show the crucial role of adults for the UAMs’ well-being: everyone, from the developers of policies to teachers, should take this aspect into account. Providing teenagers with appropriate communication technologies, ensuring the support of caregivers and teachers, and organising activities that strengthen peer networks are the actions of paramount importance, to ensure their welfare.