bluuebunny/crossref_metadata_2025 huggingface dataset:
Airport Disaster Planning — A Different Approach
Authors: Eaton C. John
Published: May 2019

The Disaster Planning for Stansted Airport, which' it is proposed will become London's third airport, with expansion to handle up to 50 million passengers per annum by the end of the decade, poses a unique problem because, unlike most other major airports, it is relatively isolated and some distance from the medical facilities required to handle a major disaster. The airport is situated about halfway between London and Cambridge, each 30 miles away, in the heart of the countryside in North Western Essex, close to its border with Hertfordshire.

In the past, the number of survivors from aircraft accidents involving narrow-bodied jets has been very small but, with the advent of the wide-bodied jets such as the Boeing 7k7, this has changed and survival rates in excess of 50% have been found. This gives a potential of more than 250 survivors from an aircraft with 500 seats, many of whom might be expected to have major injuries.

The nearest hospital is k miles away which, in the event of a major disaster, could take up to 6 seriously injured and 12 walking wounded within the first 4 h. Twelve miles away is another hospital which could take the same number, and 20 miles away is a further hospital which could handle up to 8 seriously injured and 20 walking wounded. The nearest hospitals with major accident departments are in North East London and Cambridge, each of which could take up to 10 seriously injured and 50 walking wounded initially.
The Organization and Alert of Medical Aid at Italian Airports
Authors: Mezzetti M.G. , Serra G.C. , Romano R. , Bianchi F.
Published: May 2019

In the event of a disaster, all personnel present in the airport area must modify their own everyday rules to ensure the best response to the emergency situation. For medical aid there are two main objectives: (a) organization of rescue operation; and (b) mustering medical resources. The initiators of the rescue operation must be the control tower staff and each Italian airport is provided with emergency plans which have been carefully studied.

Information systems between the accident site and the centers of available medical resources, however, are less well organized. These can be simplified by the use of a video terminal, connected with a data system elaborator. The Lombardy region plans to install a video-terminal in every Regional Hospital in order to be able to present the airport with the up-to-date situation of vacant beds and of medical staff present in the hospital for emergency tasks.

It is proposed that the alert from the accident site should be in two phases. Initially, a general alert must be given, followed after a short time by a more detailed specific alert. The first phase must be addressed to those departments that, independently of the type of the disaster, will always be involved in any critical situation, e.g., Ambulance Headquarters, ICUs, Blood Centers, Emergency Departments. The second phase will be used to inform hospital departments specializing in treating the pathology prevailing in the particular disaater. In airport disasters, the pathology which prevails will include major and multiple injuries with blood loss and burns.
Triage in Airplane and Airport Disasters
Authors: deSinner F.
Published: May 2019

Triage or sorting means recognition and selection of the injured for treatment and transport. It is a very important and difficult task and has the aim of saving as many lives as possible, ensuring the best possible treatment, leading to the best possible recovery. Triage requires judgment, courage to assume responsibility and determination to act rapidly. The examination of a patient to assess his priority includes his vital functions, his specific injuries and his environment. Triage leads to the following priorities:

(1) immediate, compulsory treatment;

(2) early treatment, within hours;

(3) delayed treatments; and

(4) slightly injured and hopeless cases.

Although triage is primarily a physician's job, trained paramedical personnel or firstaiders may be the first to arrive at the scene and should to able to recognize and treat casualties requiring immediate care on the spot.

The first physician at the disaster site may not be well qualified in emergency medicine, and indeed may have little or no experience in handling casualties. He may be a passenger involved in the emergency landing of an airplane. Let us therefore examine three possible situations:
The Potential of Emulsified Fluorocarbon Blood Substitutes in Treating Disaster Victims
Authors: Geyer Robert P.
Published: May 2019

As with many manmade and natural disasters, those involving airports and aircraft give rise to a number of emergency medical situations that require prompt and sometimes drastic responses. The number of casualties can be very large and adequate hospital facilities can be quite distant from the disaster site, even when the latter is at an airport. Obviously, the situation is compounded when the accident has occurred at a remote place or involves a landing on water. Emergency measures are therefore of great importance to minimize loss of life and reduce exacerbations of initial injuries. Fortunately, major disasters are infrequent. This very fact, however, makes it even more impractical at most airports to have on hand at all times a large supply of blood and the facilities for typing and cross-matching rapidly and accurately. No supply of blood, of course, exists on any ordinary aircraft. There are therefore good reasons why artificial preparations capable of carrying oxygen and carbon dixoide and maintaining blood volume have potential usefulness in airport and airplane disasters.

These disasters can involve one or more forms of bodily injury including physical trauma, burns, and asphyxiation (Table 1). All can lead to shock, and some form of emergency treatment is often required to restore blood volume and oxygenation levels. Since any delay in initiating treatment must be avoided, the required materials should be on hand and in a form which allows their being used without delay. Artifical blood replacement preparations (1-4) based on liquid perfluorochemicals have a number of desirable attributes in this regard.
The Application of Entonox for Pain Relief
Authors: Baskett Peter J.F.
Published: May 2019

Pain relief is important — not only for humane reasons — but also for protection of the circulation and tissue perfusion which suffer as a result of the enormous secretion of catecholamines which occur. In the operating room during anesthesia we take care to combat this trend by giving adequate analgesics, and it is logical that we should attempt to take similar steps in the prehospital care phase.

One of the reasons why the provision of analgesia is so poor in practice is that the usual parenteral agents — the opiates — are accompanied by side effects which are particularly dangerous in the seriously ill or injured patient. The introduction of low dose ketamine, however, has altered this position somewhat, offering, as it does, good analgesia without significant depression of respiration or the circulation.

A major practical difficulty in providing analgesia outside hospital lies in the fact that the majority of the patients are being cared for by personnel who are not physicians. We, therefore, need an agent which can be administered by an ambulance attendant or trained rescuer. In many countries the opiates and ketamine may only be administered by a physician and therefore they are effectively ruled out for the majority of patients.

Let us look at the properties of an ideal analgesic for use outside hospital. It should be: 1) effective but safe; 2) have no undesirable side effects; 3) have a rapid onset and short duration of action; 4) be easy to administer; and 5) be capable of being used by paramedical personnel.
Simple Oxygen Supply
Authors: Serra G.C. , Mezzetti M.G. , Romano T. , Bianchi F. , Parabiaghi R.
Published: May 2019

The use of oxygen in emergency situations outside hospitals is limited by difficulties in supply. Low capacity cylinders (100-120 1) weigh 3-4 kg, and have cumbersome mechanisms for pressure and flow reduction. Disposable cylinders of oxygen from a chemical source create the possibility of the contents running out, and are fragile. Particularly when exposed to high pressures or temperature.

Mouth-to-mouth remains most rational and effective. Problems include aesthetic concern and exhaustion in rescuer. It is possible, however, to adapt a Brooke or a Safar airway for use with oxygen, by attaching a tube with tape near the proximal outlet of the airway. This apparatus has been tried on 4 patients during general anesthesia with thiopentone-succinylcholine-neuroleptics—for appendectomies using controlled ventilation with expired air with oxygen added. Tidal volumes of 350-500 ml of air/oxygen were delivered at a frequency of 6-8 breaths per minute. The nose was closed by a clip. Sellik's maneuver could prevent gastric inflation. The color of blood was normal, arterial pressure and pulse did not change, and skin was dry. No fatigue or other effects were reported by the anesthesiologist-“rescuer”. In outdoor use, where oxygen from a chemical source is used, the problems associated with the exothermic reaction can be limited by cylinder lagging with openings to disperse heat. A flow of O2 6-7 1/min is sufficient to support a critical situation. It allows O2 enrichment for mouth-to-mouth, mouth-to-mask, mouth-to-airway, or bag valve ventilation. Modest cost, and low weight allow large numbers to be stored for airport disasters, when resuscitation is performed on a large scale for many victims.
Tanning Procedures in the Management of Burn Disasters
Authors: Hettich R.
Published: May 2019

The protective effect of an artificial tanning scab seems to be greater than that of the physiologic eschar, in controlling the invasion by micro-organisms and the loss of water, electrolytes and plasma. Allgöwer, et al. confirmed a reduced toxicity in burns, using experimental tanning procedures. Applying mercurochrome 2%, tannic acid 5% and silver nitrate 10% is a simple and most effective local treatment, especially when large numbers of patients are involved. No further topical agents are necessary for days, and infusion therapy may consist simply of water and electrolytes for the first 2k h, and the patients are stabilized for transport. A most important advantage of this procedure, which was obvious in all our patients, is the reduction of pain. Resorption of the applied substances must be considered. Toxic side-effects have not been seen with the use of tannic acid 5% nor with silver nitrate 10%. Increased blood levels of mercury have been found, however, but they have not caused toxic complications in more than 200 monitored patients. Betadine may be used instead of mercurochrome as a local antiseptic. The antiseptic effect of betadine was found to be greatly prolonged after tanning, as compared to 100 patients with comparable burns without tanning—with septic complications having been reduced in the tannic acid group.
Comments on the Social Dimension of Airplane Disasters
Authors: Clausen Lars
Published: May 2019

There are different social actors (or “collective social actors”) in a disaster who may have differing ideas on the “ideal passenger in a disaster”.

This is an euphemism; it includes a gang of hijackers. Any suggested human failure in a complicated technical environment might be threatened or committed deliberately. Some attitudes of the ideal passenger, as seen from the point of view of the pirate, show that: i) the passenger ought to keep quiet, should not panic and should readily obey orders of the hijackers and must be easily persuaded by bullying tactics; and ii) the passenger must be selective in observing his situation —neither apparently looking at anybody nor recognizing anything, except to obey the commands he might receive from the hijackers.

This one did not want the disaster to happen, e.g., a rescue team. It also has an “ideal passenger” in mind: i) he should not panic, and should keep quiet, after having given a signal that he is alive and needs help; ii) he should follow orders and should place his trust in personnel; and iii) he should do his best to help himself and identify emergency situations in his co-passengers and help them. The moment rescuers arrive he has to change his role and follow orders.

This is the company operating the flight, as presented by the pilot and his crew: i) this party is interested in a quiet and non-panicking passenger; ii) expect him to follow their advice on trust; and iii) require him to take precautions seriously; i.e., reading the emergency regulations put in front of his seat, without unduly worrying about them, but remembering them when disaster strikes.
Lessons from a DC10 Crash, American Airlines, Flight 191, Chicago, Illinois
Authors: Baker Frank J. , Franaszek Jacek B.
Published: May 2019

With the development and deployment of commercial jet aircraft in the mid 1950's, airline travel has become commonplace throughout the world. A rapid increase in the numbers of aircraft, airline routes, and flying time has occurred. New technology has added sophisticated and complicated gear to aircraft and their support systems. Every new system has the potential for failure and to some extent additional components increase the risk of technological breakdown. The increased chance of technological breakdown favors an increase in aircraft accidents. Fortunately, development and utilization of sophisticated redundant electronic and mechanical improvements aimed specifically at improving safety have also occurred. The results of these changes over the past twenty-five years has been a decreasing rate of accidents per mile flown. Due to the tremendous increase in flying, however, the absolute numbers of accidents associated passenger morbidity and mortality have risen (1). For the health care system, the major impact has resulted from the absolute increase in aircrash victims.

Aircraft accidents have regularly produced mass casualty incidents with the number of victims ranging from a few to several hundred. Aircraft accidents can be divided into essentially four types: mid-air crashes (so called “hard impact”); crashes on takeoff; crashes on landing; and on-ground accidents (“soft impact”). Mid-air accidents are frequently away from population centers and usually there are no survivors. The medical impact therefore is minimal. Accidents occurring on takeoff, landing, and on the ground, occur at or close to airports, and the nature of the accident is such that there may be many victims (1).
Pulmonary Trapping of Platelets and Fibrin after Musculoskeletal Trauma — A Model to Detect and Quantify Post-Traumatic Pulmonary Microembolism
Authors: Jansson I. , Lovén L. , Rammer L. , Lennquist S.
Published: May 2019

In discussions of the pathogenesis of posttraumatic respiratory distress syndrome (adult respiratory distress syndrome, ARDS), thromboembolism or microembolism (6) is the most frequently suggested mechanism. Embolic material released from the site of injury and/or intravascularly formed aggregates of platelets and fibrin are thought to plug the pulmonary capillaries, giving rise to diffuse pulmonary damage. Pulmonary trapping of platelets and fibrin has been studied in various animal models in which intravascular aggregation was induced pharmacologically, without trauma (2). Studies in patients with ARDS are difficult to standardize, and the results therefore are often inconclusive. We have evolved an experimental model (5) by means of which changes identical to ARDS can be induced from reproducible musculoskeletal trauma in anesthetized pigs. The pigs are observed under anesthesia for three days after the trauma under standardized and carefully controlled conditions. The aim of the present study was to use this model for registration and monitoring of pulmonary trapping of platelets and fibrin in animals with ARDS following standardized trauma, without adding any pharmacologic substance that could influence platelet aggregation or fibrinolysis. Pulmonary trapping was determined by external detection of 51Cr-labeled homologous platelets and 125I-labeled human fibrinogen, intravenously administered before anesthesia and trauma.
Importance of Early Fracture Stabilization in Preventing Post-Traumatic Pulmonary Changes
Authors: Jansson I. , Eriksson R. , Liljedahl S.O. , Lovén L. , Rammer L. , Lennquist S.
Published: May 2019

Adult respiratory distress syndrome (ARDS) is the most fatal complication after severe trauma (1,3). ARDS is seen in multiple injured patients with fractures and the risk for ARDS increases with the number of fractures (9). One of the theories concerning the etiology in ARDS is, that tissue thromboplastine from the site of the fracture and surrounding soft tissue activates the coagulation system resulting in pulmonary microembolism (6). Riska (8) has noticed by clinical experience that increased frequency of early fracture stabilization by internal fixation in multiply injured patients has dramatically reduced the frequency of post-traumatic respiratory insufficiency. The aim of the present study was to investigate the effect of primary fracture immobilization on post-traumatic pulmonary changes in pigs. We used a model in which anesthetized pigs can be subjected to trauma and then observed for several days, while still under anesthesia, under careful respiratory and circulatory control, by means of repeated chest x-rays and postmortem macroscopic and microscopic examination of lung tissue.

Twenty-six pigs (Swedish Landrace), weight 17–23 kg were used. Chest x-rays were done in all animals before the experiment excluding those pigs with any pulmonary changes. The pigs were anesthetized with pentobarbital and pethidine, and tracheostomy, carotid artery cateterization and cystostomy were performed.
Noninvasive Core Rewarming in Hypothermia (Abstract)
Authors: Kristensen G. , Gravesen H. , Jortening H.
Published: May 2019

Profound hypothermia has a high mortality if not treated with active rewarming. Most successful is central core rewarming. Many methods have been designed for this purpose: mediastinal irrigation, colon irrigation, peritoneal dialysis, and warm water via a Sengstaken-Blakemore esophageal tube.

A new esophageal tube was constructed for this study. The tube consists of a small, stiff and narrow inner tube, placed inside a larger thinwalled outer tube. Warm water (41-42°C) is circulated from a waterbath via the inner tube to the outer tube and then back to the waterbath. Five healthy mongrel dogs were anesthetized, intubated and made hypothermic. All dogs were paralyzed with pancuronium to eliminate shivering. The only fluid given was isotonic saline to compensate urine loss (50-75 ml/hour). At a core temperature below 30°C the esophageal tube was inserted, and rewarming started when temperatures had reached 27.1-24.7°C. Rectal and peripheral temperatures were monitored, and in 3 dogs blood temperature was also followed.

Up to the cardiac safety temperature (31°C) the blood temperature increased 4.6°C ± 0.79 (SD) (Fig. 1, whereas the rectal temperature rose 3.74°C ± 0.76 (SD) (Fig. 2). The peripheral temperature showed only a minor increase below a central core temperature of 30°C. This means that a secondary temperature decrease is eliminated with this method. No cardiac arrhythmias or other complications were noted. these results correspond to those with peritoneal dialysis (1), and show a greater temperature rise than with use of a modified Sengstaken-Blakemore tube (2). (Supported by the Danish Medical Research Council.)
Rationale for Open-Chest Cardiopulmonary Resuscitation
Authors: Alifimoff J.K. , Stajduhar K. , Safar P. , Bircher N. , Steinberg R. , Sotosky M. , McNulty P. , Stezoski W.
Published: May 2019

Present national and international guidelines for resuscitation call for open-chest cardiopulmonary resuscitation (CPR) instead of standard external CPR under the following circumstances associated with pulselessness:

1) chest already open;

2) penetrating thoracic trauma;

3) suspected intrathoracic hemorrhage;

4) suspected pulmonary embolism (thoracotomy permits disruption or removal of emboli);

5) deep hypothermia (open chest allows direct warming of the heart for defibrillation); and

6) no palpable artificial pulse during standard external CPR basic life support, as is sometimes encountered in cases of barrel chest or spine deformities.

We will present evidence in support of a 7th indication, that is when standard external CPR advanced life support efforts do not result in the prompt restoration of spontaneous circulation, as may be the case after prolonged unwitnessed cardiac arrest or in patients with severe myocardial disease.

Historically, open-chest CPR has been used effectively to reverse cardiac arrest in laboratory animals since the 1980s and in patients since 1900. We conducted interviews with Drs. DelGuercio, Johnson, Stephenson and Leighninger (for Beck), who have had extensive experience with open-chest CPR. All confirmed personal experience of one of us (PS) with open-chest CPR in the 1950s, and anecdotal reports, that during direct cardiac massage, the heart usually regained color, spontaneous breathing returned, survivors had a very low incidence of neurologic deficit, and complications were almost non-existent. Stephenson's review of 1200 cases of open-chest CPR hospital-wide between 1900 and 1950 (1) report an overall recovery rate of 30%. However, after Kouwenhoven's report on closed-chest CPR in 1960 (2), open-chest CPR became a forgotten art.
Effect of Methylprednisolone and Reduced Glutathione on Survival in Mice and Hepatic Energy Metabolism in Rats with Endotoxin Shock
Authors: Kosugi I. , Tajimi K. , Okada K.
Published: May 2019

Reduced glytathione (GSH) is the tripeptide of glycine, cysteine and glutamic acid and is widely distributed in the body. FSH has been reported to comprise at least 90% of the nonprotein sulfhydryl (NPSH). Although the role of GSH in the tissue has not been clearly established, it is known to be a cofactor for enzymes, a substrate in detoxifications, and a free radical scavenger.

Several investigators have reported that the level of NPSH, mainly GSH, in the tissue was decreased in several types of shock and that exogenous administration of GSH has beneficial effects on shock (1,2). This study was designed to evaluate the effects of GSH on the survival rate in mice and the hepatic energy metabolism in rats after administration of endotoxin. These results were compared with those of methylprednisolone sodium succinate (MP), since many investigators have reported that the large doses of glucocorticoid have beneficial effects in several types of shock in experimental animals and in man (3,4).
Emergency and Disaster Medicine: Assignments and Perspectives
Authors: Koslowski L.
Published: May 2019

Eugene Ionesco once remarked that an excess of politics and an exaggeration of sports are characteristics of our contemporary civilization. The excess of politization affects all parts of our public life, including medicine and its specialty Disaster Medicine. Political ideologies try to usurp a field that has solely humanitarian objectives, that depends on providing for and applying relief to many people in acute distress. There are already many relief organizations and ambulance services, physician staffed emergency medical services systems and first aid trained laymen. There are state and federal disaster relief authorities. Why then was it necessary to add another organization to this sometimes confusing manifold, the German Society on Disaster Medicine?

Emergency medicine is for the individual. It must provide optimal care for each single injured or sick person — except for the shortterm management of multiple casualties. Emergency medical missions are limited by time and locality. These missions are hospital services extended to the scene of the accident and work in connection with hospitals. Disaster medicine is for the masses. Its task is to do the best possible for the largest number of people at the right time and at the right place. This implies that in a disaster situation, optimal care for every single individual can and should not be the goal, but rather the best possible care for the largest number. Disaster medicine has to work in large areas, supraregional and long-term. It needs numerous treatment facilities and several steps or levels of treatment. Therefore it requires a firm medical coordination of lay help, primary professional help, transportation, and specialized hospital treatment with maximal efficiency.
Emergency Health Services Plan for the Tuscan Region
Authors: Galanti Claudio , Stratini Piero , Boncinelli Sergio , Marsili Massimo , Lorenzi Paola , Fontanari Paolo , Pezzati Silvia
Published: May 2019

The aim of this planning project is to ensure prompt and efficient emergency health services to all people in the regional territory of Tuscany, and to establish suitable conditions for an efficient intervention by the National Health Service in situations brought about by unforeseen events which may have serious, often disastrous, consequences. This effort — quite demanding from an organizational and economic point of view — may be successful only if we assume that the time-space unpredictability of emergencies cannot be understood in absolute terms, but in relation to a series of conditions and situations present in everyday reality. Only by reducing to the minimum the unpredictability factor both quantitatively and qualitatively this purpose can be achieved. Risk factors should thus be accurately related to the territory's population distribution, geomorphology, and socio-health conditions.

Since emergency medical care must be carried out without delay, each response must involve all components, concomitantly or in sequence so that the intervention is not regarded as concluded at any one stage. It must be open to integration best suited to the situation. There is need for a multidisciplinary approach to emergencies from the first response to definitive care.

The model of health services planning necessary to achieve all this envisages a series of interventions — 1) to develop interconnections between intramural medicine and health services carried out in the field in order to allow rational use of existing structures, such as the emergency department; 2) to establish coordination focal points which can ensure, outside a hospital, the same level of treatment in emergency situations that will be carried out intramurally, despite the unavoidable changes in methodology; and 3) to activate information and self-training programs designed to encourage the development of a cultural and operative relationship between the health services and the needs of the community.
Organization of Hospital for Intra-Hospital Emergencies
Authors: Tresalti E. , Cicchetti A. , Rossi G. , Contegiacomo P.
Published: May 2019

The need to arrange the assistance beforehand and therefore prepare for the prevention of damage to people and property that may result from accidents or events of considerable magnitude occurring inside the University Hospital, “A. Gemelli,” has led to several laws of the Constitution of the Italian Republic (Article 35), the Criminal Code (Articles 437 and 451), and the Civil Code (Article 2087): The law of Feb 12, 1955, #51 (Official Gazette 54, March 7, 1955); Decree 547 of April 27, 1955 “Regulations for the prevention of industrial accidents” and Decree 302 of March 19, 1956.

The study of these assistance procedures has led to the formulation of an emergency plan divided into two basic parts: prevention of accidents, and rescue operations.

By prevention we mean: a) The training of all staff and Managing Bodies of our Faculty/Staff to take effective action in the case of an intra-hospital accident, b) The need for detailed information on the various procedures to be used depending on the gravity of the event, c) Awareness of the civil and criminal responsibilities relating to the various management and non-management levels in case of emergency.

The training plan for the whole staff, approved by the management administrative, technical and medical bodies, consists of theoretical and practical courses. These courses, which started in June 1983 are “modular.” The staff will take part in them as homogeneous groups, for a period of time which will vary, in regard to the number of hours and kind of instruction, and in relation to what each group has to learn about work safety, fire prevention and emergency measures.
Transplant Team in Mass Casualties
Authors: Agnes S. , Magalini S.C. , Castagneto M.
Published: May 2019

The topic of this paper is not only of concern to people interested in transplantation. The organization described stemmed from the experience of the earthquake in southern Italy in 1980, in which physicians of our transplant center participated only as surgeons. We feel that a tranaplant team could be useful in a mass casualty situation with the intent to help in the triage of the seriously injured, select patients with brain death, and transport selected donors to transplant centers.

The problem of triage in mass casualties is by itself a difficult and complex ethical and practical issue (1). The first hours after any disaster has occurred are crucial in dividing patients into different categories and in putting them into the care of specialized physicians, according to their primary lesions. Often severely traumatized people are discovered late and do not get the primary intensive assistance which will allow them to stabilize their clinical condition (2).

According to the type of disaster, the percentage of head trauma patients varies greatly, reaching its peak in case of earthquakes (approximately 4% of victims died of head trauma), air crashes and building destructions (3). It is reasonable to think that often head trauma is associated with multiple traumas and that in some cases (direct trauma of the most important organs, crush lesions, etc.) this may represent a contraindication to considering the patient as a donor. Generally, however, head trauma with brain death, even associated with different lesions but without metabolic, septic or cardiovascular alterations, must at least be considered for organ donation (4).
Life history, development and behaviour ofEldana saccharinaWalker on sugar-cane in southern Ghana
Authors: Sampson M. A. , Kumar R.
Published: May 2019

FemaleEldana saccharinaWalker was found to lay 327 ± 17.1 eggs within a period of 4 days and required three surfaces to lay eggs which were mainly deposited on the inner side of leaf sheaths fitting tightly on to the sugar-cane stalk. The mated females laid more eggs per female (327.0 ± 17.1) than virgin females (212.3 ± 5.5). The incubation period of the eggs ofE. saccharinawas found to be 5.64 ± 0.01 (5–7) days in the laboratory and 5.82 ± 0.03 (5–7) days in the field. The mean larval duration was 31 days and pre-pupal period lasted 2.05 ± 0.05 days. Larvae were found to exude a brownish liquid from their mouth in the direction of the invading predators. The newly hatched larvae spread out in 1–3 days of hatching. The mean growth ratio of the larval instars was 1.54 ± 0.05. Pupae frequently occurred very close to the exit hole (less than 5 cm) and the pupal period varied from 7 to 13 (9.76 ± 0.05) days. The life cycle ofE. saccharinawas completed in 49 (36–62) days. The pre-oviposition period was 2 days and the female reproductive life lasted 4 days. It takes about 53 days for a succeeding generation to be produced. Adults ofE. saccharinasurvived from 6 to 13 days. Adults reared from field collected larvae snowed a sex ratio of 42:51 which was significantly different from 1:1 in the laboratory bred stock, at the 5% level of probability. A comparison of the life cycle ofE. saccharinapopulations in Ghana and Uganda suggests the existence of two biotypes of the pest.
Occurrence of Coelomomyces indicus, a fungal pathogen of malaria mosquito vector, Anopheles gambiae complex along the Kenya coast
Authors: Otieno W. A. , Odindo M. O. , Sabwa D. M.
Published: May 2019

A survey of the natural enemies of the main malaria vector in Kenya, Anopheles gambiae Giles, revealed the occurrence of a fungal pathogen in field populations of mosquito larvae. Light and scanning electron microscopy was used in the examination of sporangia of the fungus in determining its identity as Coelomomyces indicus Iyengar (Order: Blastocladiales; Family: Coelomomycetaceae). The resting sporangia were found in the thoracic and abdominal cavities of the larvae. A mortality of 63% or higher was found to occur among the larvae of A. gambiae in a two season observation along the Kenyan coast. The authors stress the need for more intensified ecological and laboratory studies aimed at developing C. indicus as a biocontrol agent.
The performance of selected rice varieties for relative resistance to stem-borer, Maliarpha separatella (Rag.), attack under field conditions
Authors: Malinga Y. W. K.
Published: May 2019

The relative resistance of rice varieties to Maliarpha separatella was studied during 1981 and 1982 long rain seasons. The observations covered the laying of egg masses, tiller infestation, incidence of “whiteheads” and, in some cases, the grain yield.

The results indicated that the varieties BG 34™8 and BG 90™2 received the highest egg masses per plot which apparently caused “whiteheads”. The remaining 10 varieties only indicated moderate response. The 1982 long rain season under no control and carbofuran 5G application regimes showed reduced tiller infestation only in BG 90™2 and Basmati 217. The five tested varieties did not show any marked difference in tiller infestation under the two regimes. Hence, BG 90™2 and Basmati 217 showed some susceptibility of M. separatella, while the rest of the varieties remained moderately resistant.

Moth population varied according to the growth stages of the rice crop in the field, with the peak occurring during the booting to maturation stages.
Schmerzen im Bereich der Vulva
Authors: Hastert Laurent , Frey Tirri Brigitte
Published: May 2019

Zusammenfassung. Viele Frauen werden das ein oder andere Mal im Leben mit Schmerzen im Intimbereich konfrontiert. So unterschiedlich diese Schmerzen in ihrer Art und Lokalisation sein können, so multipel sind die ihnen zugrundeliegenden Ursachen. Neben Infektionen und Entzündungen, die oft einfach zu behandeln sind, gibt es allerdings auch viel komplexere, oft verkannte Krankheiten wie die Vulvodynie. Mit diesem Artikel möchten wir Ihnen einen Einblick in die verschiedenen Arten dieser Schmerzen, deren Ursachen, deren mögliche Therapien und deren Bedeutung für die tägliche Praxis geben.
When the Fun Is Over
Authors: Cardini Brian B. , Freund Alexandra M.
Published: May 2019

Abstract. How do we know when an activity has exhausted us or helped us recover? In this paper, we present a motivational approach to exhaustion and recovery that takes into account the multidimensional nature of the constructs. The account details three psychological processes that may – individually and in interaction – underlie exhaustion and recovery. Specifically, we propose that changes in mood, subjective time perception, and opportunity costs experienced during an ongoing effortful or relaxing activity indicate a person’s momentary degree of exhaustion and recovery and impact the decision of whether the person should continue or disengage from the activity at hand. Addressing developmental changes across adulthood, we present two opposing hypotheses on how younger and older adults may differ in their experiences of exhaustion and recovery: (i) Older adults may experience an accelerated subjective time perception compared to younger adults and may thus feel less exhausted (more recovered) than younger adults after spending an identical amount of time engaged in an effortful (relaxing) activity. (ii) Older adults may be more sensitive toward increasing opportunity costs experienced during an effortful or relaxing activity and may therefore feel exhausted or recovered faster than younger adults.
Comprehensive Assessment of Models and Events Using Library Tools (CAMEL) Framework: Time Series Comparisons
Authors: Rastätter Lutz , Wiegand Chiu P. , Mullinix Richard E. , MacNeice Peter J.
Published: May 2019

The Comprehensive Assessment of Models and Events using Library Tools (CAMEL) framework leverages existing Community Coordinated Modeling Center services: Run‐on‐Request postprocessing tools that generate model time series outputs and the new Community Coordinated Modeling Center Metadata Registry that describes simulation runs using Space Physics Archive Search and Extract metadata. The new CAMEL visualization tool compares the modeled time series with observational data and computes a suite of skill scores such as Prediction Efficiency, Root‐Mean‐Square Error, and Symmetric Signed Percentage Bias. Model‐data pairs used for skill calculations are obtained considering a user‐selected maximum difference between the time of observation and the nearest model output. The system renders available data for all locations and time periods selected using interactive visualizations that allow the user to zoom, pan, and pick data values along traces. Skill scores are reported for each selected event or aggregated over all events for all participating model runs. Separately, scores are reported for all locations (satellites or stations) and for each location individually. We are building on past experiences with model‐data comparisons of magnetosphere and ionosphere model outputs from GEM2008, GEM‐CEDAR Electrodynamics Thermosphere Ionosphere, and the SWPC Operational Space Weather Model challenges. The CAMEL visualization tool is demonstrated using three validation studies: (a) Wang‐Sheeley‐Arge heliosphere simulations compared against OMNI solar wind data, (b) ground magnetic perturbations from several magnetosphere and ionosphere electrodynamics models as observed by magnetometers, and (c) electron fluxes from several ring current simulations compared to Radiation Belt Storm Probes Helium Oxygen Proton Electron instrument measurements, integrated over different energy ranges.
Fast‐Forward to Perturbed Equilibrium Climate
Authors: Saint‐Martin D. , Geoffroy O. , Watson L. , Douville H. , Bellon G. , Voldoire A. , Cattiaux J. , Decharme B. , Ribes A.
Published: May 2019

The equilibrium climate sensitivity, that is, the global‐mean surface‐air temperature change in response to a doubling of the carbon dioxide concentration is a widely used metric in climate change studies. Its exact value is rarely known because its estimation requires a long integration time of several thousand years. We propose a method to estimate an accurate value of the equilibrium response from fully coupled climate models at a reasonable computational cost. Using this method, our state‐of‐the‐art climate model CNRM‐CM6‐1 reaches a stationary state after only few hundred of years of integration. This “Fast‐Forward” method consists of an optimal two‐step forcing pathway designed using the framework of a two‐layer energy balance model. It can be applied easily to any coupled climate model.
Velocity Rotation Events in the Outer Magnetosphere Near the Magnetopause
Authors: Matsui H. , Farrugia C. J. , Goldstein J. , Torbert R. B. , Argall M. R. , Vaith H. , Russell C. T. , Strangeway R. J. , Giles B. L. , Pollock C. J. , Taguchi S. , Hosokawa K.
Published: May 2019

We report velocity rotation events with amplitudes more than a few tens of kilometers per second observed by the Magnetospheric Multiscale mission. The events are detected in the outer magnetosphere near the magnetopause at approximately noon magnetic local time. When we examine one event, velocity and magnetic field variations are correlated. Accelerated electrons >100 eV are present. The azimuthal propagation direction is opposite to that of the background convection, implying that the structure and the background have different sources. The magnetic field variation can be approximately fitted to that of the line current. It is inferred that bundles of magnetic field lines with the same helicity propagate with the Alfvén velocity along the background magnetic field. One possible source is a flux transfer event. In addition, the variation in the solar wind dynamic pressure may also affect the velocity rotation. We have found 18 events during the first 2 years of Magnetospheric Multiscale operations. The derived properties are generally similar to those from the event study. For some events, we have identified a flux transfer event as a possible source. Again, the dynamic pressure variation may be the cause as well. The events reported resemble in some respects crewcuts and midday auroral brightening sequence, as measured by ground‐based optical instruments.
A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian influenza viruses in Vietnam
Authors: Nguyen Lam Thanh , Firestone Simon M. , Stevenson Mark A. , Young Neil D. , Sims Leslie D. , Chu Duc Huy , Nguyen Tien Ngoc , Van Nguyen Long , Thanh Le Tung , Van Nguyen Hung , Nguyen Hung Nam , Tien Tien Ngoc , Nguyen Tho Dang , Tran Bich Ngoc , Matsuno Keita , Okamatsu Masatoshi , Kida Hiroshi , Sakoda Yoshihiro
Published: May 2019

This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014–2017. Epidemiologically, H5 HPAIVs were frequently detected in apparently healthy domestic and Muscovy ducks and therefore these are preferred species for H5 HPAIV detection in active surveillance. Virologically, clade 2.3.2.1c and 2.3.4.4 H5 HPAIVs were predominant and exhibited distinct phylogeographic evolution. Clade 2.3.2.1c viruses clustered phylogenetically in North, Central and South regions, whilst clade 2.3.4.4 viruses only detected in North and Central regions formed small groups. These viruses underwent diverse reassortment with existence of at least 12 genotypes and retained typical avian-specific motifs. These H5 HPAIVs exhibited large antigenic distance from progenitor viruses and commercial vaccines currently used in poultry. Bayesian phylodynamic analysis inferred that clade 2.3.2.1c viruses detected during 2014–2017 were likely descended from homologous clade viruses imported to Vietnam previously and/or preexisting Chinese viruses during 2012–2013. Vietnamese clade 2.3.4.4 viruses closely shared genetic traits with contemporary foreign spillovers, suggesting that there existed multiple transboundary virus dispersals to Vietnam. This study provides insights into the evolution of Vietnamese H5 HPAIVs and highlights the necessity of strengthening control measures such as, preventive surveillance and poultry vaccination.
Temporally Resolved Intensity Contouring (TRIC) for characterization of the absolute spatio-temporal intensity distribution of a relativistic, femtosecond laser pulse
Authors: Haffa Daniel , Bin Jianhui , Speicher Martin , Allinger Klaus , Hartmann Jens , Kreuzer Christian , Ridente Enrico , Ostermayr Tobias M. , Schreiber Jörg
Published: May 2019

Today’s high-power laser systems are capable of reaching photon intensities up to 1022 W cm−2, generating plasmas when interacting with material. The high intensity and ultrashort laser pulse duration (fs) make direct observation of plasma dynamics a challenging task. In the field of laser-plasma physics and especially for the acceleration of ions, the spatio-temporal intensity distribution is one of the most critical aspects. We describe a novel method based on a single-shot (i.e. single laser pulse) chirped probing scheme, taking nine sequential frames at frame rates up to THz. This technique, to which we refer as temporally resolved intensity contouring (TRIC) enables single-shot measurement of laser-plasma dynamics. Using TRIC, we demonstrate the reconstruction of the complete spatio-temporal intensity distribution of a high-power laser pulse in the focal plane at full pulse energy with sub-picosecond resolution.
Herbivore-induced volatile emission from old-growth black poplar trees under field conditions
Authors: McCormick Andrea Clavijo , Irmisch Sandra , Boeckler G. Andreas , Gershenzon Jonathan , Köllner Tobias G. , Unsicker Sybille B.
Published: May 2019

Herbivory is well known to trigger increased emission of volatile organic compounds (VOCs) from plants, but we know little about the responses of mature trees. We measured the volatiles emitted by leaves of old-growth black poplar (Populus nigra) trees after experimental damage by gypsy moth (Lymantria dispar) caterpillars in a floodplain forest, and studied the effect of herbivory on the transcript abundance of two genes involved in the biosynthesis of VOCs, and the accumulation of defence phytohormones. Herbivory significantly increased volatile emission from the experimentally damaged foliage, but not from adjacent undamaged leaves in the damaged branches (i.e., no systemic response). Methylbutyraldoximes, 4,8-dimethyl-1,3,7-nonatriene (DMNT), (Z)-3-hexenol and (E)-β-ocimene, amongst other compounds, were found to be important in distinguishing the blend of herbivore-damaged vs. undamaged leaves. Herbivory also increased expression of PnTPS3 (described here for the first time) and PnCYP79D6-v4 genes at the damaged sites, these genes encode for an (E)-β-ocimene synthase and a P450 enzyme involved in aldoxime formation, respectively, demonstrating de novo biosynthesis of the volatiles produced. Herbivore-damaged leaves had significantly higher levels of jasmonic acid and its conjugate (−)-jasmonic acid-isoleucine. This study shows that mature trees in the field have a robust response to herbivory, producing induced volatiles at the damaged sites even after previous natural herbivory and under changing environmental conditions, however, further studies are needed to establish whether the observed absence of systemic responses is typical of mature poplar trees or if specific conditions are required for their induction.
Associations of physical activity and egg intake with hypertension among Chinese middle-aged and older population
Authors: He Haizhen , Zhang Ting , Zhou Jing , Zhu Zhu , Na Xiaona , Zhou Guirong , Zhuang Guoliang , Liu Aiping
Published: May 2019

To explore the independent and interaction associations of physical activity (PA) and egg intake with hypertension. A cross-sectional study of 2189 individuals (aged ≥50 years) selected using multi-stage stratified random sampling was conducted in Mentougou of Beijing, China. Data of PA and egg intake were obtained from questionnaire survey, and blood pressure from physical examination. Individuals were divided into four groups by the level of PA: low, medium, high level 1 and high level 2; and were also divided into three groups by daily amount of egg intake: <1 egg/day, 1 egg/day and >1 egg/day. Self-reported hypertension was defined if individual had a self-reported diagnosis of hypertension or use of antihypertensive medication; examined abnormal blood pressure was defined if individual didn’t belong to self-reported hypertension and mean blood pressure was above 130/80 mmHg measured during this examination. After adjusting demographic characteristics, health behavior, BMI, and family history of CVD, compared with medium level PA group, high level 2 group was associated with higher self-reported rate (OR: 1.5, 95% CI: 1.18–2.01) and examined abnormal rate (OR: 1.8, 95% CI: 1.21–2.20). The self-reported rate and examined abnormal rate in <1 egg/day group were both higher than 1 egg/day group (OR: 1.4, 95% CI: 1.06–1.91; OR: 1.4, 95% CI: 1.08–1.92). Compared with medium level PA and 1 egg/day group, high level 2 and >1 egg/day group with higher examined abnormal rate (OR: 2.3, 95% CI: 1.28–4.01), high level 2 and <1 egg/day group with higher self-reported rate and examined abnormal rate (OR: 2.5, 95% CI: 1.10–3.82; OR: 2.9, 95% CI: 1.54–4.96). In conclusion, excessive high level PA and inadequate egg intake were associated with hypertension, respectively, and the association further increased when both existed at the same time. Besides, moderate PA combined with reasonable egg intake was associated with the low examination rate of hypertension.