bluuebunny/crossref_metadata_2025 huggingface dataset:
Martwicze zapalenie tkanek twarzoczaszki (tzw. rak wodny, noma) w obozie Auschwitz
Authors: Ciesielska Maria
Published: February 2024

Necrotizing facial tissue also known as water cancer or noma is a devastating opportunistic infection which destroys the tissues of the face. The risk factors are poverty, malnutrition, poor oral hygiene, diabetes, alcohol abuse and smoking, low birth weight, Acquired Immune Deficiency Syndrome (HIV). Without appropriate treatment, the mortality rate from noma is 70-90% especially among children. It evolves from a necrotizing gingivostomatitis to widespread orofacial gangrene causing deformation. From the end of May 1943 to August 1944, SS-Hauptsturmführer Dr. Josef Mengele held the post of head physician in the „Gypsy camp” in Auschwitz. At the behest of the Institute for Anthropological and Biological-Race Research at the Kaiser Wilhelm Institute in Dahlem, he undertook anthropological studies of various racial groups, mostly Sinti and Roma and also of twins, especially identical twins. A disease known as water cancer, appeared in the Zigeunerlager. Previously unknown among prisoners, it attacked children and young people especially. Mengele began experiments on its causes and treatment. Most of the noma patients died. The research lasted from autumn 1943 to June 1944, i.e. until the dissolution of the hospital in the Romani camp, which was closed down soon afterwards. Five thousand Romani prisoners were killed in the gas chambers and the remaining Romani were sent to other concentration camps.
Rectal examination in a patient with faecal incontinence
Authors: Bielecki Krzysztof
Published: February 2024

The paper presents the key elements of clinical examination in patients with symptoms of faecal incontinence. After ensuring positive atmosphere and intimacy, a thorough interview to collect medical history and physical examination should be performed in accordance with the principles of general medical diagnosis. In a medical history examination, it is particularly important to obtain information on past diseases and operations, current ailments and medications used. A physical examination includes viewing, manual examination, percussion and auscultation. During the entire examination, we give the patient a chance to express himself, and the doctor listens carefully to what the patient says. Their findings are as important in the diagnosis and treatment of faecal incontinence as specialist tests.
Gastrointestinal obstruction in the course of incarcerated Richter’s hernia in the peritoneal drainage catheter tunnel – a case report
Authors: Nycz Michał , Krawczyk Wiktor , Mietła Mateusz , Święch Michał , Lorenc Zbigniew
Published: February 2024

Gastrointestinal obstruction is a condition in which the passage of contents through the intestine is arrested. Thorough physical examination as well as imaging and laboratory diagnosis are needed for a correct diagnosis. Richter’s hernia is a rare form of abdominal hernia in which a part of the intestinal wall is entrapped in the hernial sac. A female patient reported to the Emergency Department (ED) with symptoms of gastrointestinal obstruction. After performing all necessary investigations, Richter-type hernia was found in the peritoneal drainage catheter tunnel, which was surgically treated. Incarcerated abdominal hernias are one of the most common causes of gastrointestinal obstruction. Richter’s hernia, which poses diagnostic difficulty despite overt clinical symptoms, and may be found even in small defects in the abdominal wall, is one of them.
Rola odruchów prymitywnych i posturalnych u dziecka
Authors: Smoleń-Kowalska Magdalena
Published: February 2024

In this article I describe primitive and postural reflexes and their role and importance in development. A child’s primitive reflexes develop already in the womb. They appear between 9 and 12 weeks after conception, but become fully mature much later. The development of technology has made it possible to observe the child’s development in the womb. Thanks to modern ultrasound examinations we can observe the child’s reflexes during prenatal life. A child coming into the world leaves an environment that fulfills his needs automatically. Postural reflexes appear after birth, within the first year of a child’s life. They develop as the baby grows and acquires new skills. Their formation is mediated by the midbrain and the cerebral cortex. Postural reflexes are automatic reactions to maintain balance, stability and flexibility of the body. The article contains 7 photos of a little girl during examination her reflexes. The following article presents how to check individual reflexes, the time when they should occur and the time when they should disappear. Persistent reflex problems are not limited to childhood. If problems resulting from pathological primitive reflexes are not corrected in childhood, they will mature with the child. Difficulties can manifest themselves in many ways for example as school difficulties or emotional difficulties.
Influence of the COVID-19 pandemic on access to dental benefits for children – a questionnaire parent’s study
Authors: Grzesiak-Gasek Iwona , Dębska-Łasut Katarzyna , Herman Katarzyna
Published: February 2024

Introduction. The COVID-19 pandemic has caused difficulties in the functioning of healthcare. Dental procedures performed in the oral cavity and generating a potentially infectious aerosol were considered to be particularly risky in terms of spreading infection. This has resulted in significant reductions in the work of dental offices during the pandemic. Aim. Getting to know the opinions of parents regarding the dental treatment of children during the pandemic, considerate the availability of dental offices, their epidemic protection and concerns about infection during the visit. Material and methods. A survey study was conducted among 146 parents of children visiting the Pediatric Dentistry Clinic at the Department of Pediatric Dentistry and Preclinical Dentistry of the Medical University in Wroclaw. Results. 45% of respondents assessed the availability of dental services at level similar to that before the pandemic, 51% experienced difficulties (21% – need to postpone the appointment, 18% – help only in emergency cases, 8% – no possibility of treatment, 3% – only continuation of treatment, 1% – teleconsultation only). Securing office against the transmission of infection was considered sufficient by 88% of the respondents. Concerns about the infection of the child during visit were reported by 35% of the respondents. 19% of parents felt that difficulties in accessing treatment had negative impact on their children’s oral health. Conclusions. Procedures should be developed to minimize the risk of infection in dental facilities during an epidemy, while maintaining optimal access to treatment.
Artist V.N. Elizarov and his collection in the collection of the Minusinsk Museum of Local Lore. N.M. Martyanova
Authors: Akhremchik Olga Gennadyevna
Published: February 2024

The subject of the research is the creative biography of Valery Elizarov, a Tuvan artist who currently lives in Abakan. Valery Nikolaevich Elizarov in 2022 donated 36 his works to the Martyanovsky Museum. The artist works in painting, graphics, arts and crafts. The basis for this study was personal meetings, conversations, interviews with the artist, his autobiography, published in a single copy by his wife, Marina Mikhailovna Elizarova, and works stored in the MBUK MKM. It is concluded that the artist's work is based on the historical and cultural heritage of the region, that his biography is not a chain of random events, but a spiritual path of knowing creativity.
The Impact of Artificial Intelligence Banking and Personal Interaction Quality towards Customer Retention with Customer Satisfaction as an Intervening Variable
Authors: Chintasi Angreani  , Nur Afifah  , Barkah
Published: February 2024

Number of digital banking transactions Indonesia based on katadata.com in August 2023 grew by 169,9% throughout the last five years in five years and the amount of third-party banking funds in Indonesia increased by 12.3% according to Indonesian Banking Statistics data for 2020-2022. Number of digital transactions at Bank Maybank Indonesia in 2022 increased by 28% and the number of accounts increased in 2022 by 34%, however the amount of funds raised by Bank Maybank Indonesia decreased by 1.19%.  It is alleged that the acquisition of accounts is not followed by customers who retain. This study was conducted to explore the effect of artificial intelligence banking and personal interaction quality on customer retention with customer satisfaction as an intervening variable. The research sample was 215 customer respondents using questionnaires and interviews. The analysis method uses Structural Equation Models Partical Least Square (SEMPLS) based on Smart Partial Least Square (Smart PLS) 3.2.9. The results of the study are artificial intelligence banking has a significant effect on customer retention, personal intelligence banking does not have a significant effect on customer retention. When mediated by customer satisfaction, artificial intelligence banking still has a significant effect on customer retention and personal intelligence banking has a significant effect on customer retention through customer satisfaction as an intervening variable.
Relokacje w łódzkiej rewitalizacji w kontekście międzynarodowej debaty na temat przesiedleń
Authors: Audycka Barbara
Published: February 2024

Celem artykułu jest analiza przypadku relokacji prowadzonych w ramach Rewitalizacji Obszarowej Centrum Łodzi w kontekście międzynarodowej debaty na temat przesiedleniom. W pierwszej części artykułu opisano przebieg debaty poświęconej przesiedleniom, z jednej strony koncentrując się na paradygmacie „prawa do pozostania”, z drugiej podsumowując aktualny stan badań w krajach Europy Zachodniej. W drugiej części opisano uwarunkowania przesiedleń w łódzkiej rewitalizacji, wynikające z aktów prawa krajowego i miejscowego oraz praktyki wdrożenia, przeanalizowano także deklaracje lokatorów dotyczące zaplanowanych powrotów. Wyniki analizy wskazują na to, że w przypadku łódzkiej rewitalizacji większość lokatorów nie korzysta z możliwości powrotu do mieszkań po remoncie; koncentracja na prawie do powrotu powinna więc ustąpić miejsca dokładnemu zdefiniowaniu i zagwarantowaniu takich warunków przeprowadzek, które będą satysfakcjonujące dla mieszkańców.
POLITYKA ZORIENTOWANA TERYTORIALNIE JAKO METODA ADAPTACJI DO ZMIAN KLIMATU
Authors: Kamińska Klaudia , Nowakowska Aleksandra
Published: February 2024

W obliczu postępujących zmian klimatu konieczne jest podjęcie działań w zakresie prowadzonej polityki rozwoju terytorialnego. Celem pracy jest pokazanie, w jaki sposób miasta wykorzystują idee place-based policy w ramach Zintegrowanych Inwestycji Terytorialnych do kształtowania działań na rzecz adaptacji do zmian klimatu. Przy wykorzystaniu metody case study oraz analizy komparatywnej pokazane zostały rozwiązania z trzech europejskich obszarów – Kornwalii i wysp Scilly w Anglii, aglomeracji ołomunieckiej Republiki Czeskiej oraz aglomeracji miejskiej Rijeka w Chorwacji. Opisane jednostki w bardzo wąskim stopniu wykorzystują mechanizm ZIT na rzecz adaptacji do zmian klimatu. Realizują głównie działania o charakterze infrastrukturalnym dotyczącym sektora transportu i energetyki. Teoretyczne założenia mechanizmu ZIT mogą być podstawą do opracowania narzędzia wdrażającego skuteczniejszą adaptację do zmian klimatu.
Higher Order Thinking Skill (HOTS) Students in Indonesia and Saudi Arabia (Comparative Study of Assessment Application in Schools)
Authors: Yarun Ayuningtias , Moch. Zainal Arifin Hasan  , Syahri Syahri , Markus Markus
Published: February 2024

In fact, the HOTS assessment is intended for students who are capable of higher-order thinking. However, the reality that occurs in Indonesia and Saudi Arabia in international competition, such as the PISA ranking, is still at level 1. This study aims to compare the application of HOTS assessments in schools between Indonesia and Saudi Arabia. This study uses a systematic review through review of students' Higher Order Thinking Skill (HOTS) journals in Indonesia and Saudi Arabia. The study's results found (1) The application of HOTS assessments in Indonesia is more of an assessment in the form of questions and reading literacy activities. Meanwhile, in Saudi Arabia, to improve students' higher-order thinking skills, they must pay more attention to learning approaches and strategies. (2) The type of assessment that exists in Indonesia today is the formative assessment to improve the learning process while summative after the learning process ends. Whereas in Saudi Arabia the assessment is more of an evaluation than a test in the realm of summative, formative and computer-assisted assessment. This research is beneficial for student achievement because there are assessment practices that suit student needs. In addition, this comparison can be a reference for further research to find similarities and differences in understanding the application of the assessment.
Penggunaan Artificial Intelligence (AI) dalam Pembelajaran: Fenomena Transformasi Otoritas Pengetahuan di Kalangan Mahasiswa
Authors: Djakfar Musthafa Fera Andriani
Published: February 2024

Currently, the use of artificial intelligence has become widespread, especially among students. However, there is a consensus that artificial intelligence brings about some changes in students' intellectual lives, particularly when used excessively. One of the tangible transformations is related to the authorithy of knowledge, where students prefer to complete assignments with the assistance of artificial intelligence without seeking other authoritative sources. This research aims to find answers to the following questions: How has the use of artificial intelligence spread among students? What significant changes in students' intellectual lives as the impact of excessive use of artificial intelligence, particularly concerning the transformation in the authority of knowledge? This study is a qualitative research with a phenomenological approach to investigate a variety of phenomena surrounding the research topic directly from the field. The research was conducted in the Department of Arabic Language Education at STAI Syaichona Moh. Cholil Bangkalan. This research found that: students use AI in learning, such as ChatGPT, chatbots, and AI-based electronic dictionaries, primarily because their lectures are related to language translation. Furthermore, this research also found that a transformation in the authority of knowledge has occurred, transitioning from lecturers and authoritative books to reliable websites, opinions of intellectual figures, and journals published by universities.
The correlation of folic acid and homocysteine serum with vascular density and retinal non-perfusion area in diabetic retinopathy
Authors: Guna Dharma Andhika , Wildan Arief , Maharani Maharani , Prihatningtias Riski , Luthfia Rahmi Fifin , Nugroho Trilaksana , Novitasari Saubig Arnila , Rikiandraswida Zahira
Published: February 2024

Background : Diabetic Retinopathy (DR) is the most common microvascular complication of Diabetes Mellitus (DM). Homocysteine has been studied as a biomarker in DR, while folic acid exhibits anti-proliferative effects in DR.

Objective : To analyze the correlation between folic acid and homocysteine serum with vascular density and retinal non-perfusion area in healthy individuals and patients with diabetic retinopathy.

Methods : This is an observational study with a cross-sectional design, conducted in Dr. Kariadi Hospital and GAKI laboratory in Semarang in January 2023. This study included 60 samples: 15 healthy individuals, 15 patients with DM but no DR, 15 patients with Non-Proliferative Diabetic Retinopathy (NPDR), and 15 patients with Proliferative Diabetic Retinopathy (PDR). Patients were examined for serum folic acid and homocysteine using blood laboratory tests, vessel density and retinal non-perfusion areas using optical coherence tomography angiography (OCTA).

Results : There was a negative correlation with weak strength between folic acid levels and retinal non-perfusion area of the retina in all samples (Folic acid levels vs retinal non-perfusion area, p = 0.009, Spearman correlation = -0.335). There was a positive correlation with weak strength between folic acid levels and vascular density in all samples (Folic acid levels vs vascular density, p = 0.009, Spearman correlation = 0.337). There was a positive correlation with moderate strength between homocysteine levels and retinal non-perfusion area in all samples (Homocysteine levels vs non–perfusion area of the retina, p = 0.001, Spearman correlation = 0.426). There was a positive correlation with moderate strength between homocysteine levels and vascular density in all samples (Homocysteine levels vs vascular density, p = 0.001, Spearman correlation = -0.414).

Conclusion : There was a correlation between folic acid and homocysteine serum with vascular density and retinal non-perfusion areas.
Engajando pacientes e acompanhantes para cirurgia segura: relato de experiência
Authors: Cruz Camille Mascena da , Lopes Michelle Mota , Santos Laryssa Noia Dias dos , Marques Patrícia Figueiredo , Queiroz Joseneide Santos , Rodrigues Urbanir Santana , Rodrigues Eder Pereira , Berhends Jamille Sampaio , Nobre Vera Patrícia Carneiro Cordeiro
Published: February 2024

Objetivo: Relatar a atividade extensionista para engajamento de pacientes e acompanhantes para prevenção de eventos adversos em situação pré e pós cirurgia. Relato de experiência: As estudantes de enfermagem intérpretes do jogo “campo minado”, com a temática da segurança do paciente sobre as metas: Comunicação efetiva, Cirurgia Segura e Prevenção de quedas, aplicaram a dinâmica em toda enfermaria cirúrgica geral e neurológica do hospital com todos os pacientes, acompanhantes e visitantes que estavam presentes no período da extensão universitária. Este jogo interativo foi acolhido de forma notável e contribuiu na capacitação destes participantes para construção da cultura de segurança nas unidades de internação. Considerações finais: A atividade favoreceu o desenvolvimento de estratégias para melhoria da segurança do paciente, contribuindo para o desenvolvimento de condutas que potencializam a assistência qualificada. Mais uma vez, a enfermagem contribuiu de forma significativa na segurança do paciente, por meio da adoção de práticas educativas, estimulando o desenvolvimento da cultura da qualidade em saúde.
Conhecimentos e vivências de mulheres sobre contracepção
Authors: Borba Keylla Gonzales , Prates Lisie Alende , Gomes Natália da Silva , Gomes Bruna Cristiane Furtado , Cherubim Daiani Oliveira , Lipinski Jussara Mendes
Published: February 2024

Objetivo: Analisar os conhecimentos e vivências de mulheres sobre contracepção.  Métodos: Trata-se de uma pesquisa qualitativa, descritiva e exploratória, desenvolvida entre os meses de julho e outubro de 2022, com 16 mulheres, em uma Estratégia de Saúde da Família, localizada na Fronteira Oeste do Rio Grande do Sul. Utilizou-se entrevista semiestruturada e análise de conteúdo temática. Resultados: As mulheres apresentam conhecimento limitado sobre o mecanismo de ação dos métodos contraceptivos, bem como sobre a sua disponibilidade no Sistema Único de Saúde. A maioria demonstrou preferência pelos métodos hormonais, apresentando receio e desconhecimento sobre outras opções. A maioria acredita que a contracepção é responsabilidade do casal. Conclusão: Conclui-se que é preciso ofertar espaços para a troca de conhecimentos sobre assuntos ligados ao planejamento reprodutivo, contribuindo para a garantia dos direitos sexuais e reprodutivos. Ainda, considera-se fundamental a necessidade de responsabilidade compartilhada acerca dos métodos contraceptivos pelos casais e maior empoderamento feminino.
Catalyst Lifetime Analysis for High-Temperature Shift Converter (104-D1) at Urea Factory
Authors: Rahmatullah Rahmatullah , Putri Rizka Wulandari , Mahendra Bobi , Arofi Hegar Tifal , Hadi Cecep Sumiratna
Published: February 2024

High Temperature Shift (HTS) Converter (104-D1) have a function to convert CO gas into CO2 in the ammonia unit. The presence of CO could be poisoning the catalyst in the ammonia converter. The performance of HTS (104-D1) was ideal if the percentage of CO outlet is above 3.41 mol % dry basis. The performance of HTS (104-D) was influenced by operating conditions (pressure and temperature) and the ratio of steam to carbon. The increase in temperature in HTS (104-D1) can increase in the reaction rate and a decrease in CO conversion due to a decrease in catalyst performance. The research aims to find out how the performance of HTS (104-D1) after Turn Around process (catalyst replacement) that reviewed based on the operating conditions and the resulting CO conversion. The analysis was carried out by comparing the CO conversion from the actual data with the CO conversion from the design data by using the regression equation method to predict the lifetime of the catalyst. CO conversion obtained from the design data is 69.42 %. Conversion of actual data in June, July, August, September and October was 67.43 %; 78.32 %; 77.93 %; 77.75 %; and 77.40 %. The lifetime of the HTS catalyst (104-D1) PUSRI-IIB was estimated to be used up to 5 years after Turn Around process.
Inspiring Students to Explore Science Topics Since 2011
Authors: Kastner Sabine , Flüeler Thomas
Published: February 2024

To succeed in Science on the Move, the nationwide competition for Swiss high school classes, students are requested to work as a team on relevant research topics. The project shapes their notion of science as one of the foundations of our society and as a possible professional field for themselves.
الترتيب الحجمي لعواصم مناطق المملكة العربية السعودية دراسة تحليلية عبر قاعدة الرتبة والحجم المعدلة وفقاً لتعداد 2022م
Authors: أبكر مصطفى محمد علي
Published: February 2024

عالج هذ البحث قضية ترتيب حواضر الإقليم الجغرافي بناء على الخصائص الحضرية ، ووفقاً لذلك تناول عواصم مناطق المملكة العربية السعودية بما فيها الرياض ، وتعلقت التحليلات بالترتيب الجغرافي الفعلي والنظري لعواصم المناطق السعودية بناء على تطبيق قاعدة الرتبة والحجم المعدلة ، حيث تعتمد القاعدة على خاصية الحجم السكاني للحاضرة باعتباره مقياساً أساسياً، وكان هدف البحث هو الكشف عن الرتب الحقيقية لعواصم مناطق المملكة حسب المؤثرات الحضرية المختلفة ، واستخدم الباحث الأسلوب الجغرافي الإحصائي والمنهج الإقليمي إضافة إلى قاعدة الرتبة والحجم المعدلة بجانب الأدوات التي شملت الخرائط والمعادلات الرياضية وبرنامج Excel 2016 و Map Distance و earth.google.com ، وخلصت الدراسة إلى: أن المنحنى النظري بعيد عن محور الخط المستقيم المفترض لقاعدة زيف Zipf وأنه يقاطع المنحنى الفعلي مدللاً على انعدام التوازن الحجمي بين عواصم مناطق المملكة ، وكانت توصيات الدراسة: ضبط التوسعات المتزايدة في المدن المليونية واتخاذ سياسة سكانية لتقريب أحجام الحواضر وتعزيز دور العوامل الجاذبة للسكان في الحواضر الصغيرة.
أهم النقاط المشتركة والمختلفة بين دوافع الإلحاد القديم والجديد
Authors: القحطاني البندري غانم سعد
Published: February 2024

تهدف هذه الدراسة لتسليط الضوء على أهم النقاط المشتركة والمختلفة حول دوافع كلاً من الإلحاد القديم والإلحاد الجديد، ومعرفة الخلفية التاريخية، والمضمون الفكري لكلاً منهما، ولتحقيق هذا الهدف استخدمت الدّراسة عدّة مناهج؛ هي المنهج التاريخي، والوصفي، والتحليلي، والمقارن. وقد أظهرت الدّراسة جملة من النتائج، وهي أن تاريخ نشأة الإلحاد القديم ظهر كردّة فعل للقمع الذي حدث من الكنيسة في العصور القديمة، بينما نشأ الإلحاد الجديد بعد أحداث الحادي عشر من سبتمبر، الذي تم فيه نبذ الأديان ورفع الشعارات التي ترمي لنفيه. كما أن هناك فروق كبيرة بين المضمون الفكري للإلحاد القديم الذي كان يعتمد على الفلسفة كرغبة في إيجاد عدداً من التفسيرات حول الحياة والطبيعة، بينما الإلحاد الجديد تعمق بالعلوم التجريبية، والنظريات العلمية بشكل كبير بالرغم من وجود بعض المضامين الممتدة بينهما. وأيضا بالرغم من ظهور الفلسفات على الساحة في الإلحاد القديم إلا أن له تأثير بسيط ونوعي مقتصر تقريبا على هذه النخبة من الفلاسفة، بينما تأثير الإلحاد الجديد له حضور قوي على الأجيال المعاصرة وعلى جميع الأصعدة الدينية، والسياسية، والاقتصادية، والاجتماعية، والعلمية. ولذا توصي الباحثة بضرورة عمل دراسات بحثية واسعة تشمل الإلحاد القديم والإلحاد الجديد بجميع تجلياته، بحيث يكون مرجع شامل بصورة مكثفة لأهم مواضيع كلا النوعين، وكذلك الاهتمام بوجود جهات إعلامية، ومراكز بحثية تكون مخصصة لمواجهة هذا التيار الفكري العقدي الذي اجتاح الساحات بكافة أنواعها؛ نظرا للتوسع الكبير الذي أصبح له وجود بصورة منشرة بين شباب وفتيات الأمة الإسلامية اليوم.
Unlocking the Secrets of Porous Silicon Formation: Insights into Magnesiothermic Reduction Mechanism using In-situ Powder X-ray Diffraction Studies
Authors: Martell Sarah , Yan Maximilian , Coridan Robert , Stone Kevin , Patwardhan Siddharth , Dasog Mita
Published: February 2024

The magnesiothermic reduction of SiO2 is an important reaction as it is a bulk method that produces porous Si for a wide range of applications directly from SiO2. While its main advantage is potential tunability, the reaction behavior and final product properties are heavily dependent on many parameters including feedstock type. However, a complete understanding of the reaction pathway has not yet been achieved. Here, using in-situ X-ray diffraction analysis, we map for the first time, various pathways through which the magnesiothermic reduction reaction proceeds. Further, we identified the key parameters and conditions that determine which pathways are favored. We discovered that the reaction onset temperatures can be as low as 348 ± 7°C, which is significantly lower than previously reported values. The onset temperature is dependent on the size of Mg particles. Further, Mg2Si was identified as a key intermediate rather than a reaction byproduct during the reduction process. Its rate of consumption is determined by the reaction temperature which needs to be >535°C. These findings can enable process and product optimization of the magnesiothermic reduction process to manufacture and tune porous Si for a range of applications.
Enzymatically Catalyzed Molecular Aggregation
Authors: Wang Wen-Jin , Zhang Rongyuan , Zhang Liping , Hao Liang , Cai Xu-Min , Wu Qian , Qiu Zijie , Feng Jing , Wang Shaojuan , Alam Parvej , Zhang Guoqing , Zhao Zheng , Tang Ben Zhong
Published: February 2024

The dynamic modulation of the aggregation process of small molecules represents an important research objective for scientists. However, the complex and dynamic nature of internal environments in vivo impedes controllable aggregation processes of single molecules. In this study, we successfully achieved tumor-targeted aggregation of an aggregation-induced emission photosensitizer (AIE-PS), TBmA, with the catalysis of a tumor-overexpressed enzyme, γ-Glutamyl Transferase (GGT). Mechanistic investigations revealed that TBmA-Glu could be activated by GGT through cleavage of the -glutamyl bond and releasing TBmA. The poor water solubility of TBmA induced its aggregation, leading to an aggregation-enhanced emission and photodynamic activities of AIE-PS. The TBmA-Glu not only induced glutathione (GSH) depletion through GGT inhibition, but also triggered lipid peroxidation accumulation and ferroptosis in cancer cells through photodynamic therapy. The exceptional cancer-targeting ability and therapeutic efficiency demonstrated by this GGT activatable AIE-PS highlighted enzymatic-mediated modulation as an effective approach for regulating small molecule aggregation intracellularly, thereby advancing innovative therapeutic strategies for various diseases.
Preparation of tunable Cu-Ag nanostructures by electrodeposition in a deep eutectic solvent
Authors: Plaza-Mayoral Elena , Dalby Kim Nicole , Falsig Hanne , Chorkendorff Ib , Sebastian-Pascual Paula , Escudero-Escribano Maria
Published: February 2024

The green transition requires the preparation of clean, inexpensive, and sustainable strategies to prepare controllable bimetallic and multimetallic nanostructures. Cu-Ag nanostructures, for example, are promising bimetallic catalysts for different electrocatalytic reactions such as carbon monoxide and carbon dioxide reduction. In this work, we present the one-step preparation method of electrodeposited Cu-Ag with tunable composition and morphology from choline chloride plus urea deep eutectic solvent (DES), a non-toxic and green DES. We have assessed how different electrodeposition parameters affect the morphology and composition of our nanostructures. We combine electrochemical methods with ex-situ scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) to characterize the nanostructures. We have estimated the electrochemically active surface area (ECSA) and roughness factor (R) by lead underpotential deposition (UPD). The copper/silver ratio in the electrodeposited nanostructures is highly sensitive to the applied potential, bath composition, and loading. We observed that silver-rich nanostructures were less adherent whereas the increase in copper content led to more stable and homogenous films with disperse rounded nanostructures with tiny spikes. These spikes were more stable when the deposition rate was fast enough and the molar ratio of Cu and Ag no greater than approximately two to one.
Immobilization of Liposomes into Porous Anodized Aluminum Oxide and Intact and On-demand Release by Ultrasonic Irradiation
Authors: Okada Masahiro , Sato Yusuke , Ogura Toshihiko , Itoh Tetsuji , Nishizawa Seiichi
Published: February 2024

Synthetic anionic liposomes represent useful models of extracellular vesicles for understanding their biological functions. Their integration into nanomaterials holds a great potential for various applications including drug delivery systems, separation techniques and containers. In this study, we report that porous anodized aluminum oxide (AAO) membranes serve as useful platforms for the integration of synthetic anionic liposomes. The examination using fluorophore (NBD)-labelled liposomes (average diameter, 122 nm) revealed that liposomes were successfully immobilized into AAO pores with no leakage for one week. We demonstrated that the immobilized liposomes could be released from AAO pores rapidly and on-demand by only one-minute ultrasonic irradiation while they did not leak spontaneously during storage in the buffer solution. Significantly, the released liposomes were found to be intact by scanning electron-assisted dielectric microscopy (SE-ADM) and spectroscopic techniques, with their size and morphology remaining unchanged compared to the liposomes before immobilization into AAO. Systematic analysis of a series of liposomes suggested that the immobilization of anionic liposomes proceeded though an ion-exchange mechanism. Intactness of released liposomes would be ascribed to the relatively weak attraction with the pore surface due to the electrostatic repulsion. The utilization of AAO membranes as beneficial platforms for integrating liposomes is anticipated to expedite the development of functional composite materials incorporating liposomes for drug delivery systems.
Polysaccharide extraction from Myxopyrum smilacifolium trunk and its antioxidant capacity
Authors: Hieu Le Trung , Le Lam Son , Nguyen Dang Giang Chau , Nguyen Minh Nhung , Tran Thanh Minh , Ho Xuan Anh Vu , Le Thuy Trang , Nguyen Viet Thang , Nguyen Quang Man , Tran Thi Van Thi
Published: February 2024

As a traditional medicinal plant in Vietnam, Myxopyrum smilacifolium has been used for a long history to treat cough, nervous disorders, numbness, rheumatism, and cephalalgia. Nevertheless, reports on the antioxidant activity and extraction of M. smilacifolium polysaccharides are still very rare. This study was designed to extract a high yield of polysaccharides from the M. smilacifolium trunk and characterize it. As a result, the maximum yield of the polysaccharides of 5.13 ± 0.05% was obtained with an extraction time of three hours, extraction temperature of 100 oC, the ratio of water to sample of 1:50 as extraction solution, extraction number of times 3, and the ratio of ethanol to extract volume 5:1 (v/v). Polysaccharides was characterized by Fourier transform infrared spectroscopy (FT-IR) and high-performance gel-permeation chromatography (HPGPC). The average molecular weight of extracted polysaccharides was around 3.78 × 105 Da. In vitro assays dan impressive antioxidant activities of the extracted polysaccharides, containing 0.2423 ± 0.0028 mg GA/g or 0.2142 ± 0.0007 μmol AS/g. The IC50 values of polysaccharides in the DPPH and ABTS methods were 0.89 mg/mL and 3.85 mg/mL, respectively.  These findings exhibited the potential for application or further research and development of polysaccharides from Myxopyrum smilacifolium.
Accountability and Transparency of the Electronic Court and Litigation Systems in Indonesia
Authors: Mukhtar Mukhtar , Lailam Tanto
Published: February 2024

The research focuses on evaluating and strengthening the electronic justice system in Indonesia, with a particular emphasis on its accountability and transparency. It is motivated by the numerous challenges in the electronic justice system implementation related to regulations, human resources, case management, and other potential emerging problems. This research employed normative and empirical legal methods. The research results reveal that electronic justice systems may be classified within the appropriate category. The most important thing is to strengthen the accountability and transparency in it towards an independence and impartiality of the electronic judiciary system through strengthening the quality assurance of the electronic judiciary system, electronic administration of the judiciary system by a clerk court based on an electronic trial recording (e-records), data security guarantees in e-court and e-litigation processes, and unlimited access assurance to space and time.
Biofilm formation by pGFPuv labeled mutant Cronobacter sakazakii in the
absence and presence of other bacteria
Authors: Dewanti-Hariyadi R. , Pratomo Y.A. , Nuraida L.
Published: February 2024

Cronobacter sakazakii has been reported to form biofilm on food contact surfaces thus
could be a potential source of contamination in food industries. This study aimed to
investigate biofilm formation by pGFPuv labeled C. sakazakii local strains on stainless
steel (SS), Buna-N rubber (Buna-N) and polytetrafluorethylene (PTFE) surfaces at various
incubation times and compare biofilm formation by C. sakazakii pGFPuv on SS in the
presence and absence of Staphylococcus aureus and Lactobacillus rhamnosus. Two
pGFPuv labeled C. sakazakii isolates were inoculated separately into broth medium
containing SS, Buna-N or PTFE coupons and incubated for 24, 48 and 72 hrs at room
temperature. Formation of biofilm by these isolates was also investigated on SS in the
presence of S. aureus and L. rhamnosus. The biofilm density was enumerated by
swabbing followed by plating. The results showed that pGFPuv labeled mutants formed
biofilms (up to 5 Log CFU/cm2
) on all food contact surfaces. The highest biofilm density
was found on PTFE while the lowest was on Buna-N surfaces. The biofilm density of C.
sakazakii pGFPuv on SS was similar irrespective of the presence or absence of S. aureus
and L. rhamnosus. This study corroborates the ability of C. sakazakii to form biofilms on
food contact surfaces and provides evidence that the density of the biofilm is not affected
by the presence of S. aureus and L. rhamnosus.
Proyecto de innovación Pongamos los ODS en danza en el grado de Ciencias de la Actividad Física y del Deporte
Authors: Mayolas-Pi Carmen , Preciado-Azanza Gonzalo , Lamiquiz-Moneo Isabel , Calvo-Lluch África , Gimeno-Marco Fernando , Grimal-Tejero Yara , Romero-Martín M. Rosario
Published: February 2024

El proyecto multidisciplinar de innovación docente Pongamos los ODS en danza es una apuesta pedagógica para desarrollar los Objetivos de Desarrollo Sostenible (ODS) en el Grado de Ciencias de la Actividad Física y del Deporte. Se pretende que los estudiantes conozcan y reflexionen sobre los ODS y sean capaces de realizar propuestas para su consecución utilizando la danza, la expresión corporal y las habilidades gimnásticas como herramientas de comunicación. Se utiliza la metodología de aprendizaje basado en proyectos. Los estudiantes reciben información sobre los ODS y en grupos de entre cuatro a seis alumnos, realizan un montaje rítmico expresivo en el que presentan ideas o acciones para lograr su consecución. Las asignaturas que participan son: Sociología de la actividad física y el deporte, Deportes rítmico-gimnásticos, Actividades corporales de expresión y Psicología de la actividad física y el deporte. Los montajes se exponen en un escenario en una jornada de puertas abiertas, tras la cual se realiza un tiempo de evaluación, reflexión y compromiso individual con los ODS.
Se concluye que este proyecto ha sido útil para trabajar la competencia transversal de la sostenibilidad con los estudiantes del Grado y mejorar su conocimiento, su concienciación y su compromiso con los ODS.
Opiniones, aceptabilidad y usabilidad de una herramienta de escape room para promover la inclusión en el ámbito universitario
Authors: Monreal Bartolomé Alicia , Puebla Guedea Marta , Gaston Faci Diego , López-Del-Hoyo Yolanda
Published: February 2024

En el ámbito universitario una de las dificultades más relevantes que se puede observar en el alumnado es la inclusión, tanto en las dinámicas universitarias como en el grupo al que pertenece. Esta dificultad se asocia con el número de abandonos que se producen en los primeros años de universidad. Esta problemática se vio incrementada por la situación de pandemia, afectando a toda la comunidad universitaria, pero especialmente al alumnado de los primeros cursos. Debido a esta situación el aula fue dividida por la mitad, limitando así el contacto interpersonal entre compañeros. El objetivo de este proyecto fue evaluar la usabilidad y la aceptabilidad de una herramienta de escape room para minimizar los problemas de comunicación intra e inter grupo, desarrollar interacciones más colaborativas y positivas, fomentar el trabajo en equipo y favorecer la inclusión del estudiantado en el ámbito universitario. Los resultados indican que la actividad de escape room propuesta logró sus objetivos, fue considerada por el alumnado una herramienta original, interesante y útil, tuvo un gran impacto en el conocimiento entre los estudiantes y en su inclusión. Esta herramienta puede ser de gran utilidad en situaciones obligadas de baja presencialidad y en la inclusión de los primeros años de universidad.
Effect of Combinations of Quadriceps Exercise and Hip Abductor Exercise on Pain in Knee Osteoarthritis Patients in Orthopedic and Traumatology Outpatient Care
Authors: Metasari Dia , Sukartini Tintin , Qona’ah Arina
Published: February 2024

Background: Osteoarthritis is a disorder of the moving joints. Pain functioning are the main complaints of the disease osteoarthritis of the knee. The purpose of the study was to analyze the effect of a combination of quadricep exercise and hip abductor exercise on pain in knee among osteoarthritis patients.Subjects and Method: The study was carried out at the East Java Regional Hospital for the period of December 2022 to March 2023. The study population was knee joint osteoarthritis patients of degree 1 to degree 2. The sampling technique used in this study was purposive sampling, with inclusion and exclusion criteria. The number of samples in quantitative research was 60 respondents. The dependent variable is pain, while the independent variable is quadriceps exercise and hip abductor exercise. The instrument used is the WOMAC questionnaire. Analysis of the study was using the Wilcoxon test and the Mann Whitney test.Results: There was a significant difference in pain between the control and intervention groups after conducting a combination of quadriceps exercises and hip abductor exercises (p=0.043)Conclusion: The combination of quadriceps exercise and hip abductor exercise is effective on pain reduction in knee osteoarthritis patients.Keywords: quadriceps, hip abductor, osteoarthritis.Correspondence: Dia Metasari. Master of Nursing, Universitas Airlangga, Indonesia. Jl. Dr. Ir. H. Soekarno, Mulyorejo, Surabaya, East Java 60115. Email: dia.metasari-2021@fkp.unair.ac.id. Mobile: +628563040303.Indonesian Journal of Medicine (2023), 08(02): 186-193https://doi.org/10.26911/theijmed.2023.08.02.08
Epidemiological Analysis of Mental Health Disorders in Patients at Psychiatric Hospitals in the Special Region of Yogyakarta, Indonesia
Authors: Rokhmayanti Rokhmayanti , Rulianawati Viandika , Astuti Fardhiasih Dwi , Hastuti Siti Kunia Widi , Rosyidah Rosyidah , Desvita Widea Rossi
Published: February 2024

Background:  Mental disorder is a condition of decreasing all psychiatric conditions that result in deviant behavior. WHO estimates that one in eight people in the world lives with a mental disorder in the world. The COVID-19 pandemic that has occurred since 2019 has had an impact and has had a major impact on the mental health of people in the world and in Indonesia. The Special Region of Yogyakarta is the province with the highest cases of mental disorders in Indonesia based on the results of the 2013 and 2018 Basic Health Research (Riskesdas) surveys. The purpose of this study was to determine the epidemiological description of mental disorders per classification in inpatients at Mental Hospitals in the Special Region of Yogyakarta in 2019-2021.Subjects and Method:  This study used a quantitative descriptive method, sourced from secondary data from Mental Hospitals in the Special Region of Yogyakarta for the period 2019 - 2021. The population in this study was 4,413, with a total sample of 3,919. The inclusion criteria are data of inpatients with mental disorders recorded in the recapitulation of medical records of inpatients at the Mental Hospital for the period 2019 to 2021. Exclusion criteria are incomplete data. The sampling technique used is total sampling. The person variable consists of a classification of mental disorders, age, gender, education level, occupation, marital status, health insurance, and end of care. The instrument used in this research is a dummy table. Data from this study were analyzed descriptively by looking at the frequency and proportion of each variable studied.Results:  The results showed that the highest disease classification was F20-F29 (schizophrenia, schizotypal disorder, and delusional disorder) 76.72%. Most of them were aged 25-44 years (55.60%), male (61.55%), graduated from high school or equivalent (46.54%), did not work (66.90%), and were not married (57.29%). Most of them use national health insurance (62.95%), end of treatment with doctor's approval (97.86%), and length of stay ≤ 42 days (95.1%). Most of the patients came from Sleman Regency (37.25%) and from urban areas (71.37%).Conclusion:  Most patients with mental disorders are in productive age. People with mental disorders are an economic burden that must be borne by their families and the government. So there is a need for comprehensive prevention efforts to reduce the incidence of mental disorders in the community.Keywords:  mental disorders, epidemiological studies, schizophreniaCorrespondence: Siti Kurnia Widi Hastuti, Faculty of Public Health Universitas Ahmad Dahlan. Jl Prof Dr Soepomo Warungboto Umbulharjo, Special Region of Yogyakarta, Indonesia. Email: kurnia.widihastuti@ikm.uad.ac.id. Mobile: +62813-2843-3256.Indonesian Journal of Medicine (2023), 08(02): 204-218https://doi.org/10.26911/theijmed.2023.08.02.10
The Effect of Ambon Banana Juice (Musa paradisiaca var. Sapientum Linn) and Sweet Starfruit Juice (Averrhoa carambola L) on Changes in Blood Pressure in the Elderly Men in the Community Health Center Work Area Tarus, Kupang Regency
Authors: Manek Nusthen Aries , Datta Frans Umbu , Refli Refli , Lalel Herianus J.D. , Manongga Stefanus P.
Published: February 2024

Background: Hypertension is a health problem that often occurs in society. Uncontrolled hypertension can trigger degenerative diseases such as heart disease and kidney failure. One of the therapies used to lower blood pressure is Ambon banana and sweet star fruit therapy.
Subjects and Method: Research on elderly men suffering from hypertension in the Tarus Community Health Center working area used a Quasi-Experimental pretest–posttest with a Control Group research design. The number of samples in this study was 20 elderly men using a simple random sampling method. The dependent variable in this study was blood pressure, while the independent variable was the administration of Ambon banana juice, sweet star fruit juice, and a combination of Ambon banana juice and sweet star fruit juice. The measuring instrument used in this research is a questionnaire. The data analysis used in this research is Anova and Post hoc.
Results: The average blood pressure in the elderly decreased after being given Ambon Banana Juice, Sweet Starfruit Juice, and a combination of Juices. The greatest reduction in blood pressure occurred in the group given Ambon banana juice (Mean= 140 mmHg; p=0.002), compared to sweet starfruit juice (Mean= 148 mmHg; p= 0.036), and these results were statistically significant. The juice combination also reduced the average blood pressure, but the results were not statistically significant (Mean= 156 mmHg; p= 0.454).
Conclusion: The average blood pressure in the elderly decreased after being given Ambon Banana Juice, Sweet Starfruit Juice, and a combination of Juices.
Keywords: hypertension, Ambon banana juice, sweet star fruit juice
Correspondence: Nusthen Aries Manek. Universitas Negri Nusa Cendana Kupang. Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur. Email: Nusthen2503@gmail.com. Mobile: 082144927619.
Occurrence of Salmonella spp. in fattening pigs at a slaughterhouse in the Czech Republic
Authors: Veselá Helena , Dušková Marta , Furmančíková Petra , Karpíšková Renáta , Kameník Josef
Published: February 2024

The aim of this study was to evaluate the occurrence of Salmonella spp. in fattening pigs in a slaughterhouse in the Czech Republic. Tonsils, mesenteric lymph nodes, and caecal contents were sampled from 120 pigs originating from eight farms. A total of 360 samples were examined. Cultivation methods were used to detect Salmonella. Suspect isolates were subjected to phenotypic identification. Serotyping was performed by slide agglutination method. The multiplex polymerase chain reaction (PCR) was used to detect genes encoding flagellar proteins. Salmonella spp. was isolated in 3 out of 360 samples (0.83%). The results proved the presence of serovars S. Typhimurium, S. Derby, and monophasic S. Typhimurium. Although our study found a relatively low prevalence of Salmonella in fattening pigs at the Czech slaughterhouse, consistent implementation of Salmonella control program during pork production is critical in order to ensure the protection of consumer health.