bluuebunny/crossref_metadata_2025 huggingface dataset:
TINDAK TUTUR DALAM WACANA KOMIK PETUALANGAN NOBITA DI LUAR ANGKASA
Authors: Dharma Putra Ida Bagus Gede , Maulana I Putu Ari Putra
Published: April 2024

Artikel yang berjudul “Tindak Tutur dalam Wacana Komik Petualangan Nobita di Luar Angkasa” merupakan hasil pendekatan ilmu pragmatik yang menitikberatkan pada jenis tindak tutur dan kategori tindak ilokusi dalam dialog (percakapan) komik Petualangan Nobita di Luar Angkasa (PNDLA). Tujuan penelitian ini adalah untuk mendeskripsikan jenis tindak tutur lokusi, ilokusi, dan perlokusi, serta untuk mengetahui jenis kategori tindak ilokusi yang muncul pada pada dialog (percakapan) komik PNDLA. Adapun hasil akhir dalam penelitian ini didapatkan dari mengetahui penilaian komik PNDLA berdasarkan perhitungan data tindak tutur lokusi, ilokusi, dan perlokusi. Berdasarkan lima belas data percakapan yang memiliki konteks percakapan yang bervariatif, ditemukan bahwa semua tuturan yang dituturkan oleh tokoh mengindikasi adanya jenis tindak tutur yang menggambarkan tindak lokusi, ilokusi, dan perlokusi. Untuk jenis kategori tindak ilokusi ditemukan tindak tutur asertif sebanyak 52 tuturan, tindak tutur direktif sebanyak 32 tuturan, tindak tutur komisif 1 tuturan, tindak tutur ekspresif sebanyak 10 tuturan, dan tindak tutur deklaratif sebanyak 4 tuturan. Berdasarkan perhitungan keseluruhan data yang dihimpun, ditemukan bahwa data lokusi modus pernyataan sebanyak 67%, kategori tindak ilokusi asertif sebanyak 53%, dan daya tindak tutur perlokusi verbal-nonverbal sebanyak 85%. Data ini menunjukkan bahwa komik PNDLA mengandung fungsi kerja sama (collaborative) karena dilihat dari segi sopan santun cenderung bersifat netral sehingga komik ini layak untuk dibaca oleh anak-anak hingga dewasa.
CODE MIXING USED BY ONE-PIECE ANIME LOVERS ON SOCIAL MEDIA COMMENTS
Authors: Karimah Syahadah Albaqiyatul
Published: April 2024

Code mixing is a common practice in communication both in formal or informal situations. The use of code mixing is not only limited to everyday oral conversations, nowadays, code mixing can also be found in posts of comments on social media. The study analyses the code mixing used by One Piece anime lovers on social media. This is a descriptive quantitative study gathered data from the comments uploaded by the anime lovers on social media namely YouTube, Instagram, and TikTok. The data gathered were analysed by using Muysken’s theory (2000) for the types of code-mixing and Hoffman’s theory (1991) for the reasons of code mixing. The results showed that in the One-Piece anime lovers’ community on social media, the most dominant type of code mixing used is insertion and the reasons for using code mixing are to talk about particular topic and creating familiar interactions in conversations only. Social factors that influence the use of code mixing include fan age demographics, trends, and language style. In addition, code mixing is also used to facilitate the understanding of a word context.
Using Artificial Intelligence to Improve Poultry Productivity – A Review
Authors: Taleb Hassan M. , Mahrose Khalid , Abdel-Halim Amal A. , Kasem Hebatallah , Ramadan Gomaa S. , Fouad Ahmed M. , Khafaga Asmaa F. , Khalifa Norhan E. , Kamal Mahmoud , Salem Heba M. , Alqhtani Abdulmohsen H. , Swelum Ayman A. , Arczewska-Włosek Anna , Świątkiewicz Sylwester , Abd El-Hack Mohamed E.
Published: April 2024

A recent study investigated the potential applications of artificial intelligence (AI) in poultry farming. One area where AI can be helpful is in the early detection of diseases. By analyzing data from various sources, such as sensor readings and health records, AI algorithms can identify potential disease outbreaks or health risks in flocks, allowing farmers to take timely preventive measures. Another area where AI can be applied is in controlling the environmental conditions of farms. By analyzing data from sensors that monitor temperature, humidity, ventilation, and lighting conditions, AI algorithms can help farmers create a comfortable and healthy environment for birds, improving their growth and reducing their stress. AI can also optimize the management of healthcare supplies for poultry. By analyzing the nutritional requirements of birds and the availability and prices of different ingredients, AI algorithms can help farmers optimize feed formulations, reducing waste and environmental impacts. Finally, the study explored the use of robots in poultry care. Robots can be used for cleaning, feeding, and monitoring individual birds. By automating these tasks, farmers can reduce labor costs and improve the efficiency of their operations. Overall, the study highlights the potential benefits of using AI and robotics in poultry farming, including early disease detection, improved environmental conditions, optimized feed formulations, and increased automation.
The treatment of severe class II division 2 patients with deep overbites and gummy smiles using lingual appliances: a case series
Authors: Anh Nguyen Viet , Ninh Dinh Vinh
Published: April 2024

The treatment of Class II division 2 patients with palatally inclined upper incisors using lingual appliances is generally challenging due to difficulties in achieving upper incisor torque control. The present case series aims to describe a simple method combining lingual appliances and mini-screws for the non-surgical management of two severe Class II division 2 patients presenting with deep overbites and gummy smiles. The treatment plans involved initial bite opening and upper incisor torque recovery, followed by distalisation of the entire upper arch using mini-screw anchorage. In one case, additional anterior labial mini-screws were necessary to assist incisor intrusion and complete upper arch levelling. Favourable treatment results suggest that lingual appliances, when combined with mini-screws and pre-torqued arch wires, may offer an effective approach for the non-surgical management of severe Class II division 2 patients with deep overbites and gummy smiles.
An Empirical Assessment of Microfinance and its Associated Socio-Economic Development
Authors: Goel Vishal
Published: April 2024

Microfinance institutions (MFIs) provide support for the sustainability of livelihood and financial inclusion through social development. Micro-enterprises helps in empowering the communities especially marginalized section worldwide. The MFIs attempt to transform the lives of poor people, through different interventions. It revolved around the social development of marginalized people. In recent decades, microfinance played a vital role in alleviating poverty and involved empowering low-income earners socially and economically. The present study intended to highlight the role of MFIs located in Jabalpur (Madhya Pradesh) in enhancing the social and economic status of beneficiaries. This study also acknowledges the significance of MFIs in eradicating poverty, through financial services. In this research, questionnaire responses were gathered and analyzed from 150 beneficiaries of three MFIs (Credit Access Grameen, ESAF, and Fusion Micro-finance) in Jabalpur. The exploratory data analysis reveals diverse findings, regarding the impact of microfinance on the socio-economic conditions of beneficiaries through improving their savings, supporting the employment generation, and as a whole improving life standards as well as eradicating poverty. Alternatively, MFI programs also assist beneficiaries in employment generation, to a certain extent. The conclusion of the research prioritizes that MFI programs ought to be accelerated more by the Government through different schemes and can be easily accessed to even remote areas for economic expansion and social development of low-privileged people.
Use of State Information Systems in Anti-Corruption Activities of Executive Authorities
Authors: Kuptsova I. V. , Lashkevich N. S.
Published: April 2024

The article reveals the most relevant direction of the state anti-corruption policy defined by the national anti-corruption plan, which consists in the use of digital and information tools that are united within the framework of state information systems. The first part of the article substantiates the use of these digital tools due to the low efficiency of preventing modern forms of corruption offences using traditional methods of anti-corruption activities. As part of the digital direction of Russia’s modern anti-corruption policy, the Ministry of Labour is charged with the collection of effective regional and federal practices in the use of information systems. The best practices selected by the Ministry were also used in the creation of the state anti-corruption information system Poseidon, which is currently the basic system for all executive authorities. The final part of the article concludes with a study of the organization of the authorities’ anti-corruption work using digital tools.
Authors: Damanik Veni Jean Gabriella , Kencana I Putu Eka Nila , Gautama I Putu Winada
Published: April 2024

Kemajuan teknologi memengaruhi kehidupan manusia, salah satunya dalam bidang perdagangan, yaitu adanya sistem jual beli secara online melalui e-commerce. Hasil riset yang dilakukan oleh Ipsos pada akhir tahun 2021 terhadap persaingan beberapa e-commerce membuktikan bahwa Shopee menjadi e-commerce yang paling diminati dan banyak digunakan oleh masyarakat Indonesia. Hal tersebut terbukti dari kualitas layanan Shopee dinilai baik oleh para konsumen sehingga meningkatkan minat dan motivasi konsumen untuk berbelanja di Shopee serta loyalitas konsumen terhadap Shopee. Oleh karena itu, penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh kualitas layanan Shopee terhadap motivasi berbelanja dan loyalitas konsumen. Untuk menjawab tujuan penelitian ini, maka digunakan metode structural equation modeling (SEM) berhierarki. Variabel laten/konstruk dalam penelitian ini adalah kualitas layanan, motivasi berbelanja, dn loyalitas konsumen yang akan dibuat dalam model persamaan struktural untuk mengetahui hubungan antarkonstruk. Berdasarkan rancangan model penelitian dan hasil analisis model struktural dalam penelitian, dibuktikan bahwa konstruk kualitas layanan mampu menjelaskan konstruk motivasi berbelanja sebesar 46,3%, sedangkan konstruk kualitas layanan mampu menjelaskan konstruk loyalitas konsumen sebesar 36,5%. Dengan demikian, dapat disimpulkan bahwa kualitas layanan memengaruhi motivasi berbelanja dan loyalitas konsumen.
Rare cause of laringeal mass
Authors: Peixoto Maria Conceição
Published: April 2024

Background:

Inflammatory, hemorrhagic, or tumoral laryngeal mass lesions can be found, but some of these lesions can be very rare, which makes the diagnosis a real challenge.

Case Presentation:

We report a case of a laryngeal/hypopharynx lesion in a 69-year-old man with a submucosal bulging in the right piriform sinus. The only notable symptom was a mild foreign body sensation. Computed tomography scan confirms the presence of an expansive lesion, with lobulated contours, cystic/with necrosis, comprising the right lateral wall of the hypopharynx, involving the piriform sinus circumferentially. Differential diagnosis with schwannoma, paraganglioma, hemangioma, or other rare laryngeal lesions has to be made.

Conclusion:

In this case, the option for the diagnostic tool was an excisional biopsy using an intralaryngeal approach. Histologic results showed a nodular fragment with hyaline replacement and central cavitation, with hematic fibrin clots, suggesting a clot/thrombus.
Prehospital airway management by health workers in Riyadh City: A local survey
Authors: Al-Rajeh Hatun , Alshehri Faisal , Alhaqbani Rayyan , Almalki Alwaleed , Barakah Nora , Albaqami Nuha , Alhasoun Saud , Alafandi Fawaz , Nawab Azzam
Published: April 2024

This study sought to determine the perception of healthcare workers (HCWs) about pre-hospital airway management and their experiences.
Methods:
This cross-sectional study was conducted among health workers at the emergency department of King Fahad Medical City in the capital of Saudi Arabia, Riyadh City. This study targeted physicians, nurses, paramedics, and respiratory therapists. Data were collected using an online questionnaire. The questionnaire included demographic characteristics, training, and experiences in airway management and a 5-item questionnaire to measure the perception of HCWs about airway management.
Results:
Of the 100 HCWs, 39% were doctors, and 37% were nurses. Approximately 23% had a poor experience with intubation. Traumatic injuries were the major difficulties involving airway management (44%). The overall perception of HCWs about prehospital airway management was good (68%), 31% were moderate, and only 1% were considered poor perception levels. No significant differences were observed between perception scores in relation to the demographic characteristics and experiences of HCWs in airway management (all p>0.05).
Conclusion:
Despite HCWs\' good perception of prehospital airway management, some gaps have been identified mainly through intubation skills and experiences. This study provided evidence that perception towards prehospital airway management was not affected by profession, years of experience, regular practice of intubation, and airway management. Regular training should be implemented, with equipment and resources should be available to improve airway management and patient quality of care.
Apropriação dos resultados das avaliações da aprendizagem para fins de reorientação da prática pedagógica
Authors: Rosa de Souza Valderlice , Borges Regilson Maciel
Published: April 2024

O artigo analisa como os professores se relacionam com os resultados das avaliações da aprendizagem de seus alunos. O referencial teórico fundamenta-se nos estudos de Vasconcellos, Hoffmann, Luckesi, Gatti, entre outros. Metodologicamente, trata-se de uma pesquisa de campo, da qual participaram professores de duas escolas estaduais do município de Pouso Alegre, Minas Gerais. Os dados foram coletados por meio de um questionário e pela realização de uma roda de conversa. Conclui-se que nem sempre os resultados da avaliação da aprendizagem são apropriados pelos docentes para a reorientação de suas práticas pedagógicas, muitas vezes, são usados para fins burocráticos, para classificar os aprovados e reprovados, e, algumas vezes, servem de base para uma intervenção pedagógica.
Palavras-chave: Avaliação da Aprendizagem. Apropriação de resultados. Prática Pedagógica.
DESAFIOS DE ENFERMEIROS(AS) NA ASSISTÊNCIA EM SAÚDE MENTAL AOS PACIENTES COM CÂNCER: UMA REVISÃO INTEGRATIVA
Authors: Pinheiro Vanessa , Ramos Lílian , Dullius Willian Roger
Published: April 2024

Este artigo tem o objetivo de reunir e resumir evidências na literatura sobre os desafios encontrados pelos enfermeiros ao prestar assistência em saúde mental em pacientes com câncer. Trata-se de uma revisão integrativa da literatura, foram selecionados artigos publicados entre 2019 e 2023, em revistas revisadas por pares e indexadas, textos disponíveis na íntegra, em português, publicados nacionalmente e classificados como acesso aberto. Artigos duplicados nas bases de dados e materiais que não referiam a temática abordada foram excluídos. A busca abrangeu o período de janeiro/2019 até março/2023, nas respectivas bases de dados: BDENF, BVSalud, LILACS, Google Acadêmico e a biblioteca Scielo. Foram utilizados os descritores neoplasias, enfermagem, assistência à saúde mental, estresse psicológico, cuidados paliativos, e o operador booleano AND. Foram eleitos quatro artigos para compor a análise qualitativa. Os artigos evidenciam que o enfermeiro apresenta restrições ao desenvolver assistência em saúde mental ao paciente oncológico e seu familiar, uma vez que há uma lacuna no processo de formação, bem como, na educação permanente deste profissional. Também, profissionais que atuam em um curto período possuem maior dificuldade na área de assistência em saúde mental, ao comparar com os profissionais com uma jornada profissional maior. O ensino e capacitação dos enfermeiros nesta área é um mecanismo de minimizar as lacunas existentes e promover melhor assistência aos pacientes oncológicos e seus familiares.
Confirmatory Factor Analysis of Sleep Quality among Grandparents Raising Grandchildren
Authors:   Southern University College Of Nursing And Allied Health, KC Clark
Published: April 2024

This study examined the factor structure of the Pittsburgh Sleep Quality Index (PSQI) and the sleep quality of custodial grandparents during the Coronavirus pandemic (COVID-19). A convenience sample of custodial grandparents (N=102) between the ages of 31 and 78 completed the Pittsburgh Sleep Quality Index (PSQI) tool.
Aspectos sintáctico-semánticos de la adquisición del inglés como segunda lengua
Authors: Oviedo A. Tito Nelson
Published: April 2024

Resumen
الأداء الوظيفي لدى عينة من الكوادر التعليمية في المدارس الثانوية
Authors: عبد غيداء وعد
Published: April 2024

يهِدف الــبحث الحالي الـتعرف على الأداء الوظيفي لدى عينة من الكوادر الثانوية ، وكذلك التعرف على الفروق الاحصائية تبعا لمتغيري الجنس والـتخصص ، وقد تحدد الــبحث الحالي بكوادر المدارس الثانوية في المدارس التابعة لقسم تربية تكريت إحدى اقسام التربية التابعة للمديرية العامة للتربية في صلاح الدين, إذ تكونت عينة البحث الحالي من (140) مدرس ومدرسة بفرعيهِا العلمي والادبي وللعام الدراسي (2021ــ2022)  اختيرت عينة الــبحث الحالي من الــمجتمع الاصلي الــمتمثل بالكوادر الثانوية الــمدارس الحكومية الـتابعة لقسم تربية تكريت والبالغة (30) مدرسة والــبالغ عددهِم (722) مدرسا ومدرسة ، وقامت الــباحثة ببناء مقياس الاداء الوظيفي بعد اطلاعها على  الادبيات الدراسات الـسابقة .
وتوصلت الــباحثة الى الـنتائج الاتي :
 1ـ لدى المدرسين والمدرسات مستوى عالِ من الاداء الوظيفي .
2ـ لا توجد فروق دالة احصائيا للأداء الوظيفي تبعا لمتغير الجنس (ذكور ـ اناث).
3ـ لا توجد فروق دالة احصائيا للأداء الوظيفي تبعا للتخصص الدراسي(علمي ـ ادبي)
Environmental Analysis of System-Wide Implementation of Delayed Deceleration Approach Procedures
Authors: Pellerito Victoria R. , Huynh Jacqueline L.
Published: April 2024

The potential of system-wide implementation of delayed deceleration approaches is presented through modeling a day of operations. Conventional approach procedures may involve early deceleration in the flight trajectory, resulting in early high-lift device deployment. Alternatively, delayed deceleration approaches involve delaying high-lift device deployment, thus maintaining higher airspeeds for longer and lowering thrust requirements, which reduces fuel burn and community noise. When implementing delayed deceleration approach procedures within traffic, the primary challenge is accrued from the variability of deceleration rates, which can significantly impact approach timing and thus separation among aircraft. In this work, a framework was developed that constructs delayed deceleration approach models based on observed radar data. This framework was then implemented on an average day at Boston Logan Airport to assess the feasibility of implementing delayed deceleration approaches on commercial traffic. The results indicate that delayed deceleration approaches can be implemented for 92.2% of the evaluated traffic without separation concerns, providing an average approach fuel burn savings of 10.27% and reducing exposure of configuration noise along the flight path by an average of 8.10 N miles of ground track distance. Therefore, implementing the delayed deceleration approach on a commercial traffic may provide environmental benefits.
Development of Multi-particulate Formulation of Glabridin with L-Phenylalanine and Its Pre-clinical Evaluation for Anti-obesity Activity
Authors: UB Vyas , KS Khobragade , PU Vyas
Published: April 2024

Obesity is a chronic condition that is defined by pathophysiological mechanisms that lead to an increase in adipose tissue mass as a result of positive energy balance. Obesity is a multi-factorial disorder involving different mechanisms of action like humoral and neurogenic actions. Hypertrophied and hyperplastic adipocytes are indicative of pathological obesity. In the current treatment regimen, the drugs used mainly focus on a single mechanism of action. Herbal medicines are reported to have anti-obesity activity but due to the presence of multiple phytoconstituents its very difficult for one to finalize the dose and issue of palatability. So the best solution is to focus on usage of active phytoconstituent as an anti-obesity medicine. A high protein diet proved to have anti-obesity activity, the main constituent responsible for this activity is L-phenylalanine which is an essential amino acid that produces its activity by stimulating the satiety centre and thus decreases food intake. In this study, we are combining glabridin from Glycyrrhiza glabra and L-phenylalanine as both show anti-obesity activity through different action mechanisms, which may result in synergism. The study aims to prepare multi-particulate system (granules) of glabridin with L-phenylalanine and evaluate their anti-obesity and hypo-lipidemic action in HFD-treated rats.
Adverse Drug Reactions at Primary Health Centres in Malaysia
Authors: Jaiprakash Heethal , Krishnaswamy Gauri , Sornam Sharmila V , Patil Ameeta , Govindaraja Chitra
Published: April 2024

Background: Adverse drug reactions can lead to a substantial economic burden on patients and the country. This study aims to analyze the pattern of adverse drug reactions and assess the causality of the adverse events and severity of adverse drug reactions in primary health centers in Malaysia. Methodology: This retrospective study used case series analysis and data from six Malaysian primary health centers. The patients were analyzed for gender, age, class of drugs involved, organ system involved in the adverse reaction, severity using Hartwig’s severity assessment scale and causality using the Naranjo ADR probability scale. Data were analyzed using descriptive statistics. Results: In 113 adverse drug reactions were reported. Cardiovascular drugs commonly caused adverse drug reaction (38%), followed by anti-infective agents (20%), skin and subcutaneous disorders were the common adverse drug reactions encountered (23%). The severity of the adverse reaction was level 2 in most patients (69. 9%). Adverse drug reaction was mostly found to be probable (48.7%), and 64% of the patients recovered from the adverse drug reaction. Conclusion: Cardiovascular drugs commonly cause adverse drug reactions. Level 2 and mild reactions were widely observed. The causality assessment was probable in most of the patients.
Development, Standardization and Evaluation of Antimicrobial Syrup
Authors: Lad Vishal , Ahmad Sufiyan
Published: April 2024

Ayurveda states that it takes more than just herbs to accomplish a medicinal impact. Optimizing its composition as a combination of herbs in a certain ratio improves its medicinal impact while reducing toxicity. The purpose of this research was to make a polyherbal syrup using aqueous extracts of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum tenuiflorum, and Punica granatum in varying proportions in order to provide such an intervention. The agar well diffusion technique was used to screen the formulation for antimicrobial and antifungal activity against various organisms, including Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus niger, which are representative of gram-positive and gram-negative bacteria, respectively. The syrup underwent review and standardization for multiple assessment criteria. Additionally, this formulation was subjected to an expedited stability test. Research demonstrated that the tested formulation outperformed the gold standard in terms of zone of inhibition. The formulation that has been produced meets all of the requirements, however, additional in-vitro and in-vivo investigations are needed to confirm its effectiveness.
Formulation and Evaluation of Lipid-based Nanoformulation of Itraconazole
Authors: Sinhal Amit , Wagh Rajendra
Published: April 2024

The powdered form of itraconazole is white, flavorless, and stable, but it dissolves slowly in water. In comparison to palmitic acid, stearic acid has a stronger affinity (2.57), as shown by the partition coefficient test. UV-visible spectra analysis reveals critical compound insights. Fourier-transform infrared (FTIR) identifies significant peaks in itraconazole and related compounds. tween 80 is selected for solid lipid nanoparticles (SLN) based on their appearance. Optimization using 0.5% w/v tween 80 yielded better particle capture. Thermal analyses display distinctive characteristics of itraconazole, palmitic acid, and polyvinyl alcohol. Viscosity studies mirror tear film behavior. Transmission electron microscope (TEM) images demonstrate SLN’s potential ocular application without irritation. Antifungal studies exhibit effective inhibition of Candida albicans and Aspergillus flavus growth. SN-7 reveals strong encapsulation efficiency, mean vesicle size, and sustained drug release over 12 hours. Pharmacokinetic studies shed light on SLNs’ influence on drug absorption and distribution, indicative of potential in drug delivery systems. These findings offer promising prospects in formulating enhanced drug delivery mechanisms and understanding their impact on drug pharmacokinetics. High-performance liquid chromatography (HPLC) analysis confirmed SN-7’s singular peak at 6.59 minutes. Both formulations showcased skin penetration and stability over three months under varied conditions. Skin irritation tests on rats indicated minimal reactions, affirming low irritancy, which is crucial for patient comfort and acceptance in topical drug delivery. These assessments ensure safety and effectiveness in treating fungal infections.
Antidiabetic Drug-loaded Solid Lipid Nanoparticle and Its Importance in Drug Delivery
Authors: P Vijayakumar , P Balaji
Published: April 2024

The global health challenge of diabetes mellitus continues to escalate, affecting millions of people worldwide. Managing this chronic condition necessitates lifelong treatment to control hyperglycemia and prevent complications. The delivery of antidiabetic medications can be improved by solid lipid nanoparticles (SLNs). This review provides an overview of current research on antidiabetic-loaded SLNs, summarizing their efficacy, safety, and challenges. Various antidiabetic agents, including insulin, metformin, sulfonylureas, and GLP-1 agonists, have been successfully encapsulated into SLNs, offering improved pharmacokinetic profiles and therapeutic outcomes. Despite their potential, optimization of SLN formulations, scale-up challenges, and translation to clinical practice remain areas requiring further investigation. With ongoing advancements in nanotechnology and drug delivery, antidiabetic-loaded SLNs hold promise for revolutionizing diabetes therapy and improving patient care
IDENTIFICATION OF SALMONELLA TYPHIMURIUM AND SALMONELLA ENTERITIDIS IN THE IMPORTED FROZEN POULTRY
Authors: Ibrahim Mohammed M.
Published: April 2024

Salmonellosis, a zoonotic illness caused by Salmonella spp., is mostly transmitted to humans through the consumption of raw animal products, particularly poultry meat. Salmonella enterica serovar Typhimurium and Salmonella enterica serovar Enteritidis are the predominant strains responsible for human infection. This study aimed to assess the prevalence of S. Enteritidis and S. Typhimurium infection in frozen imported poultry using a triplex PCR technique. A total of 110 samples were chosen using the cluster sampling technique from the Ibrahim Khalil border throughout the summer and autumn of 2023. Following the cultivation of the meat samples in enrichment and selective media, suspicious colonies were obtained. Subsequently, DNA extraction was conducted, and the Salmonella isolates were identified using triplex PCR. Three (3) sets of primer pairs were utilised to target the invA gene for the Salmonella genus, the prot6 gene for the S. enteritidis serovar, and the fliC gene for the S. typhimurium serovar. The prevalence of Salmonella infection in frozen poultry meat was 12% (13 out of 110 samples). Among the contaminated samples, 38% (5 out of 13) were recognised as S. enteritidis and 30% (4 out of 13) were recognised as S. typhimurium. The findings of this finding suggest that frozen poultry meat pose a significant danger for zoonotic infections caused by S. typhimurium. and S. enteritidis.
Micrognaţia – diagnostic prenatal
Authors: Maier Calina , Folea Diana , Vlădăreanu Radu , Tocariu Raluca , Şerban Marcela , Mitran Mihai , Brătilă Elvira
Published: April 2024

Early detection of micrognathia during prenatal care is crucial to mitigate the associated risks and prevent un­fore­seen emergencies requiring invasive procedures, like tracheo­stomy. It enables proper planning for delivery in spe­cia­lized tertiary care centers staffed with experienced teams in managing such cases. This proactive approach en­hances cli­ni­cian readiness, facilitates decision-making re­gar­ding ma­nage­ment strategies in advance, and fosters im­proved fa­mily education and support. The primary goals of this pa­per are to provide a comprehensive review of diverse diag­nos­tic techniques for micrognathia and to suggest a clear and pragmatic prenatal approach to ad­dres­sing this con­di­tion. Furthermore, we present relevant ultra­so­no­gra­phic pictures of fetal micrognathia from our personal data­base.
Peptide Macrocyclization via Intramolecular Interception of Visible-Light-Mediated Desulfurization
Authors: Smith Frances , Meehan Declan , Griffiths Rhys , Knowles Harriet , Zhang Peiyu , Williams Huw , Wilson Andrew , Mitchell Nicholas
Published: April 2024

Synthetic methods that enable the macrocyclisation of peptides facilitate the development of more effective therapeutic and diagnostic tools. Herein we report a peptide cyclisation strategy based on intramolecular interception of visible-light-mediated cysteine desulfurisation. This method allows cyclisation of unprotected peptides in an aqueous solution via the installation of a hydrocarbon linkage. We explore the limits of this chemistry using a range of model peptides of increasing length and complexity, including peptides of biological/therapeutic relevance. The method is applied to replace the native disulfide of the peptide hormone, oxytocin, with a proteolytically/redox-stable hydrocarbon, and internal macrocyclisation of an MCL-1-binding peptide.
A guidebook for sustainability in laboratories
Authors: Freese Thomas , Kat Renate , Lanooij Suzanne D. , Böllersen Tanja C. , De Roo C. Maurits , Elzinga Nils , Beatty Meagan , Setz Brian , Weber Roza R. , Malta Irene , Gandek Timea B. , Krikken Arjen , Fodran Peter , Pollice Robert , Lerch Michael M.
Published: April 2024

This guidebook aims to improve lab users’ everyday practices to become more sustainable. Specifically, this guidebook provides practical suggestions on how to effectively use lab instruments and resources and on how to acquire data. We provide advice to labs covering disciplines such as biology, chemistry, computational science, engineering, life sciences, materials sciences, medicine, pharmacy, and physics. As every lab is different, it may occur that alternative measures are required, advice may be outdated or not applicable, and sometimes laboratories may not be able to comply with measures of other laboratories.
Design of Experiments-Based Optimization of an Electrochemical Decarboxylative Alkylation using a Spinning Cylinder Electrode Reactor
Authors: Petrović Nikola , Cumming Graham R. , Hone Christopher A. , Nieves- Remacha María José , García-Losada Pablo , de Frutos Óscar , Kappe C. Oliver , Cantillo David
Published: April 2024

A design of experiments model has been developed to optimize an electrochemical protocol for the decarboxylative N-alkylation of pyrazole in a spinning cylinder electrode reactor. The electrochemical reaction requires the incorporation of molecular sieves as an additive to ensure the absence of moisture and prevent potential electrode corrosion issues. The spinning cylinder electrode reactor proved to be an idea platform to scale up this transformation, involving a suspension of solid particles, to multigram scales. The reaction model, which showed an excellent fitting with the experimental data, provided insights on the effect of important electrolysis parameters unique to this reactor design, such as the electrode spinning speed, on the reaction conversion and selectivity. Furthermore, the design of experiments also supplied optimal electrolysis parameters for this complex multivariable reaction system, resulting in full conversion of the substrate and excellent selectivity for a 600 mL volume reaction in recirculation flow mode, with 94% isolated yield for the target N-alkylated product.
Modelo EFQM y TQM, ¿es uno mejor que el otro?... Un análisis bibliométrico.
Authors: Puebla Manuel Alfonso , Alvarez Aros Erick Leobardo
Published: April 2024

El objetivo de este estudio es mostrar la conexión que existe en torno a la Excelencia del Negocio con la Administración Total de la Calidad y el modelo de la Fundación Europea para la Administración de la Calidad, basado en una perspectiva de similitud, exclusión o complementariedad entre ambos. Para contrastar los propósitos anteriores, se realizó un estudio bibliométrico en publicaciones relevantes, que dieron como resultado similitud entre ambos, pero lo más importante, se observa una evolución del concepto de Administración Total de la Calidad a transformarse en el concepto Excelencia del Negocio, al cual se le adhiere el modelo de modelo de la Fundación Europea para la Administración de la Calidad.
También se encontró que el modelo EFQM muestra la evolución del concepto de Administración de la Calidad que ha sido generada por el ambiente VUCA (por sus siglas en inglés: volátil, incierto, complejo y ambiguo) en el que se desempeñan las organizaciones actúales, resultando este estudio una guía para las organizaciones, estudiantes y académicos interesados en explorar los atributos del modelo EFQM para la operación organizacional.
Prácticas sostenibles en el desempeño financiero de empresas mexicanas
Authors: Arango Herrera Eduardo , De la Garza Cárdenas Manuel Humberto , Doria Mendoza Francisco Javier
Published: April 2024

Las prácticas sustentables representan para las compañías una opción para mantener un nivel de competitividad en el mercado y (finanzas saludables) un estado financiero saludable. Mantener un desempeño financiero sostenible permite un crecimiento adecuado bajo acciones de responsabilidad social empresarial (RSE). El objetivo principal de la investigación es analizar el efecto de las prácticas de RSE en el desempeño financiero en empresas de la Bolsa Mexicana de Valores (BMV); para lograr lo anterior, se recolectó, de fuentes secundarias, datos de 109 empresas que cotizan en la Bolsa Mexicana de Valores entre el 2011 al 2018; finalmente, se efectuó un análisis de datos de panel. Los resultados muestran un efecto positivo y significativo de las prácticas sostenibles conjuntas (ESG scores) en el desempeño financiero, manteniendo el mismo efecto en su score individual. Este hallazgo refuerza el impacto positivo de las prácticas de responsabilidad social corporativa como prácticas sostenibles para las corporaciones mexicanas, así como la creación de valor para ser consideradas a los intereses de los inversionistas.
ESTADO DA QUESTÃO: NEUROCIÊNCIA E PESQUISA-AÇÃO NA FORMAÇÃO CONTÍNUA DE PROFESSORES
Authors: Da Silva Jean Evren Ney
Published: April 2024

Este artigo corresponde a um estudo sobre a interlocução entre os conceitos da neurociência e da pesquisa-ação e suas contribuições para a formação contínua de professores. A pesquisa bibliográfica foi a abordagem teórico-metodológico que situou e fundamentou o objeto de investigação. O software StArt foi a ferramenta usada para realizar a revisão bibliográfica. A pesquisa teve o intuito de fazer um levantamento das produções científicas disponíveis no Portal de Periódicos da Capes, por meio da base de dados Scopus e Web of Science, no período de 2011 a setembro de 2022. Para a análise e discussão dos resultados aqui apresentados, contou-se com os aportes teóricos de autores, como: Nóbrega-Therrien e Therrien (2004), Menezes, Nóbrega-Therrien e Luz (2018), Silva e Morino, (2012), Cosenza e Guerra (2011), Ghedin e Franco (2015). Com base na leitura dos trabalhos encontrados nas bases de dados pesquisadas, conclui-se que a neurociência, nos cursos de formação contínua de professores, pode ser considerada uma realidade. Assim, os avanços que a neurociência tem alcançado podem servir para embasar, teoricamente, os cursos de formação de professores e, consequentemente, contribuir nos processos de ensino e de aprendizagem nas escolas.
APROXIMAÇÕES TEÓRICAS ENTRE O SOCIOCONSTRUTIVISMO VYGOTSKIANO E O CONHECIMENTO ESPECIALIZADO NA ÁREA DE EDUCAÇÃO EM CIÊNCIAS E MATEMÁTICA
Authors: Marques Marcela , Mello Irene Cristina de'
Published: April 2024

O Socioconstrutivismo é uma abordagem teórica fundamentada na ideia de que o conhecimento é construído socialmente por meio da interação entre os indivíduos e o ambiente, desempenhando um papel fundamental na compreensão das características de aprendizagem no âmbito educacional. Por este atributo, aproxima-se a teoria Socioconstrutivista de Vygotsky à teoria do Conhecimento Especializado de Professores, que se refere à compreensão única e profunda de que os professores têm (ou devem ter) sobre o conteúdo que ensinam e sobre como ensiná-lo eficazmente aos discentes. Este tipo de conhecimento vai além do conhecimento acadêmico do conteúdo e inclui uma série de elementos que são essenciais para uma prática educativa. Alguns desses elementos compõem o Conhecimento das Características de Aprendizagem dos modelos teóricos do Conhecimento Especializado de Professores de Matemática e das Ciências (Biologia e Física). São esses elementos que foram apropriados para se aproximar as duas teorias, a fim de se embasar epistemologicamente as propostas dos paradigmas dos conhecimentos necessários à profissão docente. Posto isso, a aproximação entre as teorias permitiu identificar elementos das Características de Aprendizagem dos três modelos teóricos do Conhecimento Especializado presentes no Socioconstrutivismo Vygotskiano, destacando-se, principalmente, a congruência de elementos que potencializam a aprendizagem, como os conhecimentos sobre os processos cognitivos, as potencialidades positivas e negativas, a compreensão e construção de significados a partir das informações apresentadas, o uso de estratégias pedagógicas para atender às necessidades dos discentes, oportunizando, assim, o alcance de um nível mais avançado de conhecimento.
Research Status and Frontier Topics of Chinese Film and Television in 2023
Authors: 胡 智锋 , 兰 健华
Published: April 2024

本文对2023年中国影视剧研究主要学术议题进行了分 析､综述｡相关议题既有影视剧基础理论研究,包括影视剧本体､美
学､文化等;也有影视剧创作与传播研究,包括叙事风格､类型结构､人 物塑造､地域形象､对外传播等;还有影视剧产业与运营以及影视剧与
新媒体等研究｡不过,相关研究在研究方法､理论与视野方面尚存在 一定局限性,需要进一步创新｡
Primary dysmenorrhea: pathophysiology, improvement of diagnostic and treatment possibilities
Authors: Fartushok T.V. , Fartushok N.V.
Published: April 2024

Primary dysmenorrhea is one of the types of gynecological pathology, the frequency of which is 45-53% in girls and young women aged 13 to 45 years, which is not given enough attention in diagnosis and treatment.The pathogenesis takes into account the increased secretion of prostaglandins F2α and E2 in the period from the beginning of pregnancy to birth, which cause pelvic pain.The diagnosis is based on the patient's history, symptoms, examination, the treatment is aimed at improving the quality of life by prescribing nonsteroidal anti-inflammatory drugs, hormonal contraceptives and the use of non-medicinal means. Purpose: to specify some links in the pathogenesis of primary dysmenorrhea and, taking into account its multicomponent nature, to evaluate the effectiveness of the proposed treatment. Under observation there were 68 women who were divided into 2 groups: 34 women with primary dysme­norrhea (main group) and 34 healthy women (control group).The diagnosis of primary dysmenorrhea was established on the basis of complaints of patients about painful menstruation and accompanying symptoms during consultations with a gynecologist and endocrinologist.Treatment of patients in the main group was carried out with the drug, which includes Vitex agnus castus L, indinol-3-carbinol, 3,3-diindolyl-methane, extract of passionflower, California Eschscholzia. In women with typical symptoms, dysmenorrhea can be diagnosed on the basis of medical information without physical pelvic examination, empirical treatment should be initiated, including nonsteroidal anti-inflammatory drugs and/or oral contraceptives, because it is a functional condition resulting from an imbalance in the hormonal regulation of myometrial contraction. As a result of the proposed treatment, pain disappeared completely in 70% of patients (23/34), as well as vegetative-vascular (from 18 to 2% of patients), vegetative (from 10 to 1% of patients), metabolic and endocrine disorders (from 15 to 2% female patients), disorders of the emotional and mental sphere (from 25 to 10% of patients). Improvement in quality of life was noted by 80% (26/34) of patients, improvement in working capacity – by 70% (23/34) of patients, after 2 months – by 95% (31/34) and 85% (28/34), respectively, after 3 months all examined patients with primary dysmenorrhea noted an improvement in the quality of life and an increase in work capacity. Sexually active women with symptoms of inflammatory processes of the genital tract, severe dysmenorrhea should undergo pelvic examination. In view of safety and high therapeutic efficiency, the drug based on Vitex agnus castus can be offered for the treatment over the period lasting at least for3 months for girls and young women aged 13 to 45 years with primary dysmenorrhea.
Prediction of risks and odds of rehospitalization of patients with eating disorders in anxiety-depressive disorders
Authors: Ogorenko V.V. , Kokashynskyi V.O.
Published: April 2024

The article represents the results of a study aimed on predicting the risks and odds of rehospitalization among patients with eating disorders in anxiety-depressive disorders. In total, 147 patients with anxiety and depressive disorders were examined. Patients were divided into a main group of 82 and a comparison group of 65 patients. The main group consisted of 21 (26%) men with a mean age of 38.33 (SD 11.53) and 61 (74%) women with a mean age of 43.15 (SD 11.44). The comparison group consisted of 19 (29%) men, mean age 37.53 (SD 9.75) and 46 (71%) women, mean age 45.22 (SD 12.17). At the time of the initial examination in the main group, 35 (43%) patients were hospitalized for the first time, 47 (57%) – rehospitalized; in the comparison group, 23 (35%) patients – for the first time hospitalized, and 42 (65%) – rehospitalized. It was found that 27  patients were rehospitalized within the next year after the intervention and treatment. Clinical-anamnestic, clinical-psychopathological and psychodiagnostic study supplemented by psychometric scales (PHQ-9 health questionnaire, Dutch Eating Behaviour Questionnaire (DEBQ), State-Trait Anxiety Inventory (STAI; C.D. Spielberger), Methodology for assessing the integrative Quality of Life Index (QLI; J.E. Mezzich)) was conducted. As a result of the study, it was found that patients in the main group had a 3.6 times lower risk of rehospitalization over the next year than patients in the comparison group. When constructing a unipolar regression model, the best predictive power and discriminative ability was demonstrated by the number of previous hospitalizations (p<0.01, AUC 0.75 (0.67-0.82)) and the intervention in the main group, which reduced the odds of rehospitalization over the next year by 4.8 times. The highest discriminative ability was demonstrated by the multiple logistic regression model (AUC 0.83 (0.76-0.88)), according to which intervention in the main group reduced the odds of rehospitalization in the next year by 5.9 times. The results of the study became the basis for the development of differentiated treatment and correctional measures for eating disorders in patients with anxiety-depressive disorders to improve the quality of care, prevent psychosocial maladjustment and improve the quality of life of this population.
ФОРМУВАННЯ МЕДІАГРАМОТНОСТІ МАЙБУТНІХ ПЕДАГОГІВ У КОНТЕКСТІ ПРОТИДІЇ НЕБЕЗПЕЦІ ІНФОРМАЦІЙНОГО НАСИЛЛЯ: КОНЦЕПТУАЛЬНІ ЗАСАДИ
Authors: Глінчук Ю. О.
Published: April 2024

Звертається увага на те, що побічним наслідком тотальної інформатизації стало стрімке поширення інформаційного насильства, яке часто реалізується через засоби масової інформації – пресу, інтернет, телебачення, радіо тощо. Акцентується, що ця проблема актуалізувалася під час війни, адже московська пропаганда постійно використовує мас-медіа для поширення панічних і антидержавницьких настроїв в українському суспільстві. Стверджується, що дієвим механізмом протидії інформаційному насильству, яке реалізується через засоби масової інформації, є медіаграмотність, яка дозволяє свідомо сприймати та критично тлумачити інформацію, отриману з різних медіа, відділяти реальність від її віртуальної симуляції. Підкреслюється важливість формування медіаграмотності майбутніх педагогів, зважаючи на їхню соціальну роль. Зазначається двовекторність формування медіаграмотності майбутніх педагогів: по-перше, вони самі повинні бути медіаграмотними, по-друге, вони повинні бути готовими до формування медіаграмотності тієї вікової категорії здобувачів освіти, з якою працюватимуть. Аналізується досвід формування медіаграмотності студентів педагогічних спеціальностей, на основі чого робиться висновок про провідну роль у формуванні медіаграмотності майбутніх педагогів загальноуніверситетських дисциплін. Водночас вказується на невикористання потенціалу безпекових дисциплін. Окреслюється низка проблем організаційно-методичного характеру у викладанні загальноуніверситетських дисциплін, які знижують ефективність формування медіаграмотності майбутніх педагогів. Робиться висновок про те, що формування медіаграмотності майбутніх педагогів повинне передусім починатись із планування відповідної змістовно-процесуальної «траєкторії», яка за законами логіки та цілісності наскрізно пройде через відповідні освітні програми, навчальні плани та плани виховної роботи. Окреслюються перспективи подальших наукових розвідок.
ВНЕСОК СЛОВАЦЬКОЇ МОВИ У ВИХОВАННЯ МУЛЬТИЛІНГВАЛЬНОГО СВІТОГЛЯДУ НАСЕЛЕННЯ ЗАКАРПАТТЯ
Authors: Фельцан І. М. , Бедевельська М. В.
Published: April 2024

Статтю присвячено дослідженню проблематики виховання мультилінгвального світогляду громадян за допомогою мов національних меншин як інтегрального компонента полікультурного середовища. Актуальність вибору словацької мови як засобу підтримки мультилінгвізму в області зумовлена сучасними тенденціями в засобах масової інформації, сфері освіти, суспільним запитом на її вивчення як другої чи третьої іноземної мови. Бібліографічний огляд засвідчив інтерес вітчизняних науковців до проблематики становлення всебічно розвиненої особистості на основі мультилінгвальної концепції розвитку лінгвістичного простору з ознаками глобалізації. В умовах активної міграції мови національних меншин відіграють важливу роль у підтримці мультилінгвізму. Встановлено, що головними формами та методами виховання мультилінгвального світогляду є освіта та засоби масової інформації, які володіють необхідним інструментарієм для створення інклюзивного іншомовного контенту, здатні охоплювати широке коло слухачів та різні категорії населення на всіх етапах розвитку. Словацька меншина Закарпаття є однією з найбільш активних у прагненні зберегти власну культурну спадщину, примножити її внесок у розвиток міжкультурної комунікації в області. З’ясовано, що, незважаючи на переваги мультилінгвального середовища, актуальними у такому соціумі стають питання щодо державного регулювання мовного процесу, співвідношення норм, стандартів, вимог до знання державної мови та застосування мов національних меншин. Наукові пошуки за темою дослідження дали можливість розкрити сутність понять «мультилінгвальний світогляд» і «гуманітарна роль мови»; можуть зацікавити менеджерів освіти, педагогів, мовознавців, культурологів і тих, хто цікавиться проблематикою розвитку мультилінгвізму в полікультурному соціумі.