bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between dietary total flavonoids and thyroid function in U.S.adults, NHANES 2007–2010
Authors: Wu Jie , Jia Chuyu , Zhang Zirui , Hou Zebin , Cui Yanhua
Published: May 2024

Background

Although small studies have shown that flavonoids can affect thyroid disease, few epidemiological studies have explored the relationship between dietary total flavonoids (TFs) intake and serum thyroid function. The aim of this research was to evaluate the relationship between TFs and serum thyroid function.

Methods

Our study included 4,949 adults from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Multivariable linear regression, subgroup analyses, and interaction terms were used to explore the relationships between TFs and thyroid function. And we also used restricted cubic splines (RCS) to investigate possible nonlinear relationships.

Results

After adjusting for covariates, we found that log10-transformated dietary total flavonoids intake (LgTFs) was negatively associated with total thyroxine (TT4) (β = -0.153, 95% CI = -0.222 to -0.084, P<0.001). Subgroup analyses revealed a stronger and statistically supported association in subjects with high annual family income (β = -0.367, P<0.001, P for interaction = 0.026) and subjects with high poverty to income ratio (PIR) (β = -0.622, P<0.001, P for interaction = 0.042). And we found a U-shaped curve association between LgTFs and free triiodothyronine (FT3) (inflection point for LgTFs: 2.063).

Conclusion

The results of our study demonstrated that a higher intake of total flavonoids in the diet was negatively associated with a lower TT4. Furthermore, the associations were more pronounced in high annual family income and high PIR adults. And we found a U-shaped relationship between LgTFs and FT3. These findings provided guidance for future thyroid dysfunction diet guidelines.
Comparison of the finishing shot and ending zone of points in Grand Slam matches of women’s doubles tennis: A cross-sectional study
Authors: Borderias Marcos , Iglesias Xavier , Martínez-Gallego Rafael , Baiget Ernest
Published: May 2024

Despite the importance of doubles tennis, there is little research on this modality of the game, especially in women’s tennis. The aim of this study was to analyse the finishing shot, the ending zone and shot by ending zone of women´s doubles matches during three Grand Slams (GS), and to observe the differences among surfaces. Twenty-one women’s doubles matches from three GS, each played on a different surface were analysed. 56.4 ± 2.3% of the points were finished from the baseline and mid court zone (BMZ), 36.1 ± 2.3% from the net zone (NZ) and 7.5 ± 4.2% from the service zone (SZ). The shot with which the points ended primarily was the forehand volley (FV) (18.2 ± 3.5%), followed by the forehand (F) (17.4 ± 4.2%), the backhand (B) (15.8 ± 4.8%), the backhand volley (BV) (12.8 ± 3.6%), the forehand return (FRT) (11.7 ± 2.7%), the backhand return (BRT) (11.4 ± 2.6%), the service (S) (7.5 ± 4.2%) and the overhead (O) (5.2 ± 3.0%). The results showed a higher percentage of F played from the BMZ in Roland Garros (RG) than in Wimbledon (W) (p = 0.011). In addition, the results also showed a higher percentage in overall F in RG than in W (p = 0.023). The FRT percentage was higher in the Australian Open (AUS) compared to RG (p = 0.026), and the O shots played from the BMZ were higher in W than RG (p = 0.038). These results suggest that in professional women’s doubles tennis the net game is a determinant factor, as well as the volley (V) and F shots. Playing aggressive and close to the net may have a positive effect on the result.
Single trial Bayesian inference by population vector readout in the barn owl’s sound localization system
Authors: Fischer Brian J. , Shadron Keanu , Ferger Roland , Peña José L.
Published: May 2024

Bayesian models have proven effective in characterizing perception, behavior, and neural encoding across diverse species and systems. The neural implementation of Bayesian inference in the barn owl’s sound localization system and behavior has been previously explained by a non-uniform population code model. This model specifies the neural population activity pattern required for a population vector readout to match the optimal Bayesian estimate. While prior analyses focused on trial-averaged comparisons of model predictions with behavior and single-neuron responses, it remains unknown whether this model can accurately approximate Bayesian inference on single trials under varying sensory reliability, a fundamental condition for natural perception and behavior. In this study, we utilized mathematical analysis and simulations to demonstrate that decoding a non-uniform population code via a population vector readout approximates the Bayesian estimate on single trials for varying sensory reliabilities. Our findings provide additional support for the non-uniform population code model as a viable explanation for the barn owl’s sound localization pathway and behavior.
Tissue distribution of Coxiella burnetii and antibody responses in macropods co-grazing with livestock in Queensland, Australia
Authors: Tolpinrud Anita , Tadepalli Mythili , Stenos John , Lignereux Louis , Chaber Anne-Lise , Devlin Joanne M. , Caraguel Charles , Stevenson Mark A.
Published: May 2024

Coxiella burnetii, the causative agent of Q fever, is a zoonotic bacteria of global public health significance. The organism has a complex, diverse, and relatively poorly understood animal reservoir but there is increasing evidence that macropods play some part in the epidemiology of Q fever in Australia. The aim of this cross-sectional survey was to estimate the animal- and tissue-level prevalence of coxiellosis amongst eastern grey (Macropus giganteus) and red (Osphranter rufus) kangaroos co-grazing with domestic cattle in a Q fever endemic area in Queensland. Serum, faeces and tissue samples from a range of organs were collected from 50 kangaroos. A total of 537 tissue samples were tested by real-time PCR, of which 99 specimens from 42 kangaroos (84% of animals, 95% confidence interval [CI], 71% to 93%) were positive for the C. burnetii IS1111 gene when tested in duplicate. Twenty of these specimens from 16 kangaroos (32%, 95% CI 20% to 47%) were also positive for the com1 or htpAB genes. Serum antibodies were present in 24 (57%, 95% CI 41% to 72%) of the PCR positive animals. There was no statistically significant difference in PCR positivity between organs and no single sample type consistently identified C. burnetii positive kangaroos. The results from this study identify a high apparent prevalence of C. burnetii amongst macropods in the study area, albeit seemingly with an inconsistent distribution within tissues and in relatively small quantities, often verging on the limits of detection. We recommend Q fever surveillance in macropods should involve a combination of serosurveys and molecular testing to increase chances of detection in a population, noting that a range of tissues would likely need to be sampled to confirm the diagnosis in a suspect positive animal.
TGF-β signaling molecules in Hydra: role of BMP and BMP inhibitors during pattern formation
Authors: Krishnapati Lakshmi-Surekha , Ghaskadbi Surendra
Published: May 2024

Understanding the evolution of body plans has been one of the major areas of investigation in developmental and evolutionary biology. Cnidaria, the sister group to bilaterians, provides an opportunity to elucidate the origin and evolution of body axes. Hydra, a freshwater cnidarian, is a useful model to study signaling pathways governing pattern formation, which are conserved up to vertebrates including humans. The transforming growth factor β (TGF-β) signaling pathway is one of the fundamental pathways that regulate axis formation and organogenesis during embryonic development. In this article, we discuss the TGF-β pathway members identified in Hydra along with other cnidarians with an emphasis on bone morphogenetic proteins (BMPs) and their inhibitors. TGF-β members, especially those involved in BMP signaling pathway, are mainly involved in maintaining the Organizer region and patterning the body axis in Hydra. Identification of other members of this pathway in Hydra and fellow cnidarians would provide insights into the evolution of body axes and pattern formation in more complex metazoans.
Termelő testek
Authors: Borbíró Aletta
Published: May 2024

A tanulmányban Veres Attila A valóság helyreállítása (Agave, 2022) című kötetének „Tranzisztor” című novelláját vizsgálom a kötet másik szövegéhez, a „Kapcsolattartásra kijelölt személy”-hez kötődő intertextuális kapcsolatainak tükrében. Veres kötete a valóság fogalmát kérdőjelezi meg, egymással versengő, illetve párhuzamosan létező, valóságokat és Magyarországokat mutat be a fantasztikum eszköztárával. Ebben a multiplikálódott (szöveg)világban a „Tranzisztor” című novella azt a kisebbségi és kiszolgáltatott helyzetet teszi hangsúlyossá, amely a marginalizált, kizsákmányolt és kitörésre (szinte) képtelen társadalmi csoportokat jellemzi. A történet szerint a mélyszegénységben élők számára az egyedüli „kitörési lehetőséget” a gyári munka jelenti. A munkások egy sárszerű anyagot esznek, amelyet a szervezetük átalakít és tesz a világok közötti kapcsolat létrehozására alkalmas termékké. A főszereplő nő nem csak erre a termelésre képes, hanem arra is, hogy megteremtse a különböző világok közötti kapcsolatot. Elemzésem azt mutatja be, hogy a főszereplő nő teste miként kerül kizsákmányolásra, miként válik szó szerint termelő testté természetes anyagcsere funkciói révén. Illetve azt vizsgálom, milyen társadalmi mobilitási, átalakulási lehetőségek adottak a mélyszegénységből való kitörésre. A másik novella segítségével pedig megmutatom, milyen a hatalmi gépezet működését, a társadalmi és önkizsákmányolás elrejtésének módozatait, melyek eredményeként a kapitalizmust szolgáló matériává alakul át a szubjektum.
Interszekcionalitás és szociálpszichológia: Roma LMBTQ+ emberek identitáskrízisei és megküzdési stratégiái Magyországon
Authors: Géczy Dorottya
Published: May 2024

Számos hazai és nemzetközi összehasonlító kutatásból tudhatjuk, hogy Magyarországon a romák is és az LMBTQ+ emberek is nagyfokú előítéletnek és diszkriminációnak vannak kitéve. Azzal azonban, hogy mi történik akkor, ha valaki roma LMBTQ+ személy, már jóval kevesebben foglalkoznak magyar kutatásokban. Az ilyen típusú „halmozottan hátrányos helyzet” jelentőségére először az 1970-es és 80-as évek feminista kritikája világított rá (Crenshaw, 1989; 2001; Hooks & Lutz 1993), szakított a fősodor feminizmusának nőket homogenizáló felfogásával és mutatott rá a nők között meglévő egyenlőtlenségekre (Sebestyén, 2016; Kóczé, 2009). Az esettanulmányban arra vállalkozom, hogy integráljam az interszekcionalitás elméletét a szociálpszichológia néhány alapvető fogalmával, a társadalmi identitás (Tajfel, 1981), előítélet (Allport, 1999), társadalmi reprezentáció (Moscovici, 1961), fenyegetett identitás, és a megküzdési stratégiák (Breakwell, 1986) fogalmaival. A tanulmányban hat, magát roma LMBTQ+ személynek valló résztvevővel történt interjúkat elemzem. Azt tárom fel, , hogy a résztvevők hogyan élik meg a „többszörös” kisebbségi helyzetet, s milyen megkűzdési stratégiákat tudnak alkalmazni.
Mit akar a nő?
Authors: Szélpál Lívia
Published: May 2024

Zadie Smith The Wife of Willesden (2021) című színdarabjában Geoffrey Chaucer A bath-i asszonyság előbeszéde és meséje című történetét gondolja újra, amely Chaucer XIV. század végén írott Canterbury mesék című művében található. Mivel a darab magyarul még nem érhető el, a tanulmány céljai között szerepel Smith írói stílusának bemutatása a magyar olvasóközönségnek. A színdarab bevezetőjében önreflexív módon elmeséli az adaptáció születését, amely egy véletlen félreértésből keletkezett egy Twitter-bejegyzés és gyenge reptéri Wi-Fi-kapcsolat révén, miként lett ez a helyzet kreatív alkotómunkafolyamattá a Covid19-pandémia idején. A tanulmányban azt vizsgálom, hogyan alakult át Chaucer eredeti története Smith szövegévé, s milyen korabeli társadalmi viszonyról árulkodik a Smith által megváltozott történet főszereplőjének, Alvitának az élete. A modern kori Kilburn városrészben, egy kocsmában meséli el történetét Alvita. Önmagához és a férfiakhoz való viszonyát, identitását gondolj újra: mit akar(hat) az élettől egy nő és mi a nő szerepe a házasság intézményében. A színdarab vegyes kritikákat kapott, amely eltérő kritikai értelmezésekre a tanulmányomban is kitérek.
„Emlékezet és diszkurzivitás transzformációi Marga Minco műveiben
Authors: Gera Judit
Published: May 2024

Marga Minco (1920–2024), holokauszttúlélő holland írónő „A lakcím” (1957/2003) című rövidtörténetén, a Keserű fű (1957/1979) című kisregényén és a Kijk ’ns in de la [Kukkants csak be az asztalfiókba] (1963) című meséjén mutatom be, hogyan, milyen transzformációk aktiválásával forgatja az írónő személyes életének elemeit előbb önéletrajzi ihletettségű irodalommá, majd milyen további transzformációkra van szükség ahhoz, hogy ugyanezekből az elemekből humorral teli, abszurd mesét konstruáljon. Ehhez többek között Ernst van Alphen „Symptoms of Discursivity: Experience, Memory and Trauma” című, 1999-ben megjelent cikkét használom fel, melyben azt állítja, hogy a tapasztalat, az emlékezet és a trauma diszkurzív alapú. A diszkurzivitás négy szimptómáját, a holokauszt négy reprezentációs problémáját különbözteti meg: a szubjektum- és objektumpozíció összemosódását, a szubjektumpozíció teljes tagadását, a narratív keretek hiányos mivoltát és a narratív keretek teljes tagadását. Ezeket mutatom ki „A lakcím” című rövidtörténetben, majd ehhez kapcsolódva vizsgálom a szubjektumpozíciót és a narratív keretet a Keserű fű című kisregényben. Végül azt a helyreállítási folyamatot vizsgálom, amelynek eredményeképpen a mesében a diszkurzívitás szimptómái felszámolódnak.
Utilization of high fly ash dosage to reduce cement consumption in concrete formulations
Authors: Davidová Vendula , David Tomáš , Reiterman Pavel
Published: May 2024

The concrete production is responsible for high proportion of total carbon dioxide emission due to enormous consumption of Portland cement. This traditional binder system is due to high autogenous emission during calcination the main carrier of such negative environmental impact. The effective way to reduce the use of Portland cement is to replace that this binding material exhibiting lower energy demandingness. This paper deals with the utilization of fly ash as Portland cement replacement, which is frequently applied in concrete industry. The paper deals the highest replacement level in accordance with valid regulations. The experimental program was focused on the properties of fresh concrete mixture and basic physical and mechanical properties of hardened concrete. The attained results confirmed good potential of this approach, however the increase of plasticizer dosage was necessary to maintain a similar consistency of fresh mixture. That is why the fresh mixture exhibited lower level of air content.
Development of hydration temperatures on cement pastes
Authors: Meruňka Milan , Šperling Petr , Hela Rudolf
Published: May 2024

This article deals with the possible combination of high temperature fly ash with fluidised bed fly ash. The main objective of the experiment is to verify the effect of the combination of these two energy by-products on simpler systems – cement pastes. In the experimental part, the evolution of hydration temperatures and the time course of volume changes were monitored. The results obtained indicate that the addition of fluid fly ash to the mixture intensifies the hydration reaction, despite the increase in the value of the water to cement ratio of the mixture. At the same time, there is a slight increase in volume changes, which can be considered as a very valuable contribution to technical practice, taking into account possible ecological or economic aspects.
The carbonation resistance of concrete on the basis of blended binders containing milled limestone
Authors: Reiterman Pavel , Davidová Vendula , David Tomáš
Published: May 2024

The current building industry is essentially changing due to implementation of new approach, which is predominantly motivated by the need to reduce its negative environmental impact. The paper is focused on the experimental evaluation of carbonation resistance in terms of accelerated tests performed on the concrete on the basis of blended binding system incorporating milled limestone. The used commercially produced cement was additionally modified by the limestone powder. The obtained results confirmed, that currently used design standards are convenient to real carbonation process, however further clinker replacement by the milled limestone causes significant loss of the durability of the hardened concrete.
Rol de la participación comunitaria en el abordaje de condiciones nutricionales asociadas a vulnerabilidad
Authors: Speziale Pablo , Araujo Catalina , Cabañas Haydee , Costa Lucas , Kuttel Yelena , Rodríguez Rostan María Laura
Published: May 2024

La participación comunitaria cumple un rol fundamental en la identificación de problemáticas sociosanitarias en distintos contextos. En el presente artículo se analizan los datos brindados por la Liga Infantil de los Barrios, agrupación que convoca a distintas familias de barrios populares con fines lúdicos y se realizan medidas antropométricas a fin de detectar situaciones de vulnerabilidad. En los hallazgos se destacan el estado de riesgo de sobrepeso y obesidad en los niños, así como la aparición de desnutrición crónica en esta misma población. En tanto en adultos se constata un aumento porcentual de la masa corporal de las mujeres que asisten a esta liga.
Gender Gap in Business Angel Financing
Authors: Bellucci Andrea , Gucciardi Gianluca , Locatelli Rossella , Schena Cristiana-Maria
Published: May 2024

This study explores the impact of gender on entrepreneurial finance, analyzing both the supply and demand sides of early-stage equity financing through Business Angel (BA) investments. The research investigates the probability of men and women-owned businesses securing BA investments and assesses whether the gender of BA investors influences financial transaction magnitudes, potentially disadvantaging women-owned businesses. Additionally, the study explores the intersection between the gender of BA investors and investees to test for the presence of any potential heterogenous behaviors in terms of average invested amounts by men (women) Business Angels towards women-(men-) owned target companies. Results reveal that women entrepreneurs receive less equity financing than men, with a lower probability of securing larger investments from men BAs. Notably, this bias is absent when women BAs invest in men-owned businesses. These patterns persist regardless of information availability and consideration of unobservable factors, suggesting a connection between this disadvantage and taste-based prejudice among men BAs.
The analytical assessment of metal contamination in industrial soils of Saudi Arabia using the inductively coupled plasma technology
Authors: Alnuwaiser Maha Abdallah
Published: May 2024

In response to significant demand for evaluating the presence of heavy elements in diverse industrial areas of Saudi Arabia, the study sought to analyze the concentration ratios of 16 elements across 11 different artificial soil types in the industrial zones situated in Riyadh, Sudair, and Al-Ahsa. To achieve this objective, the research utilized the wet digestion technique and employed an ICPE-9000 spectrophotometer for quantifying element concentrations. The study had a dual focus: initially, it sought to gauge the pollution attributed to heavy metals arising from enrichment processes, and second, it evaluated the geographical accumulation of pollutants in the soil. The results revealed varying concentration levels of heavy metals across the industrial areas under study. Specifically, the soil in the Yanbu region exhibited the highest concentration values for iron, manganese, zinc, chromium, nickel, copper, cobalt, cadmium, and beryllium. In contrast, the soil in the industrial area of Riyadh had the highest concentration values for lead, mercury (Hg), molybdenum (Mo), selenium (Se), and arsenic (As). Furthermore, the highest concentration of Cd was recorded in the soil of the Jubail region. Conversely, the soil in the Al-Ahsa region displayed the lowest concentration levels for these heavy metals. The conductivity of the synthetic soil ranged from 0.47 to 6.07 μS·cm−1, accompanied by a pH range of 6.6–8.6. The results emphasized the fluctuations in element concentrations, indicating significant implications for both environmental and human health. Notably, around 20% of the gathered samples showed concentrations of heavy elements like Mo, As, Hg, and Se that surpassed the allowable limits.
Airlift bioreactors for bioremediation of water contaminated with hydrocarbons in agricultural regions
Authors: Sandoval-Herazo Elber José , Rodríguez-Torres Israel , Espinosa-Reyes Guillermo , Lizardi-Jiménez Manuel Alejandro
Published: May 2024

The superficial gas velocity (Ug) values of 1.0, 1.5 and 2.0 cm s−1 showed a diesel consumption of 59.70, 58.20 and 65.20 %, respectively. The productivity of the airlift bioreactors (ALBs) was 0.030, 0.026 and 0.034 g L−1 d−1, respectively. During 10 days of operation, the emulsification index (E
24 %) values for Ug 1.0, 2.0 and 2.0 cm s−1 were 15.79, 15.07 and 12.85 %, respectively. Likewise, an increase in the degradation and suspended solids was observed when increasing the Ug from 1.0 to 2.0 cm s−1 of the ALBs, whereas a decrease in emulsification index E
24 % was observed for an Ug of 2.0 cm s−1. According to the results, the Ug of 2.0 cm s−1 was the most effective for increasing the degradation of diesel and growth of the consortium among the Ug evaluated. Furthermore, the reduction of E
24 % in this Ug suggests that the consortium uses a mixed form of hydrocarbon consumption, both by direct contact and in emulsified form.
Mark Ups and Pass-Through in Small and Medium Retailers for Rice, Tomato Sauce and Oil
Authors: Blanchard Pablo
Published: May 2024

In this paper, we recover and decompose markups, and estimate the pass-through rates from cost to prices in small and medium retail stores for oil, tomato sauce, and rice in Uruguay using a structural model of demand and assumptions about the competitive behavior of producers. The market power for these products has been under study by the Commission of Promotion and Defense of Competition since 2016, and the proposed methodology allows for a deeper exploration of the measurement and understanding of the origin of that market power. In addition to providing a fundamental input for competition defense policies in Uruguay, this study enhances the international academic literature by contributing evidence on cost-to-price pass-through in a developing economy with potentially greater market power than that found in developed countries. About 65 % of the market power under the Nash Bertrand assumption is explained by the ability of firms to differentiate products and 35 % by the ownership structure in the case of oil and sauce. In the case of rice, 49 % is explained by differentiation and 51 % for ownership structure. Finally, the pass-through rates are low for the three products, being under both behavioral assumptions lower than 55 % for the three products.
Mediation analyses for the effect of antibodies in vaccination
Authors: Fay Michael P. , Follmann Dean A.
Published: May 2024

We review standard mediation assumptions as they apply to identifying antibody effects in a randomized vaccine trial and propose new study designs to allow the identification of an estimand that was previously unidentifiable. For these mediation analyses, we partition the total ratio effect (one minus the vaccine effect) from a randomized vaccine trial into indirect (effects through antibodies) and direct effects (other effects). Identifying

λ

\lambda

, the proportion of the total effect due to an indirect effect, depends on a cross-world quantity, the potential outcome among vaccinated individuals with antibody levels as if given placebo, or vice versa. We review assumptions for identifying

λ

\lambda

and show that there are two versions of

λ

\lambda

, unless the effect of adding antibodies to the placebo arm is equal in magnitude to the effect of subtracting antibodies from the vaccine arm. We focus on the case when individuals in the placebo arm are unlikely to have the needed antibodies. In that case, if a standard assumption (given confounders the potential mediators and potential outcomes are independent) is true, only one version of

λ

\lambda

is identifiable, and if not neither is identifiable. We propose alternatives for identifying the other version of

λ

\lambda

, using experimental design to identify a formerly cross-world quantity. Two alternative experimental designs use a three-arm trial with the extra arm being passive immunization (administering monoclonal antibodies), with or without closeout vaccination. Another alternative is to combine information from a placebo-controlled vaccine trial with a placebo-controlled passive immunization trial.
Increases in drug-related infant mortality in the United States
Authors: Kitsantas Panagiota , Densley Sebastian , Rao Meera , Sacca Lea , Levine Robert S. , Hennekens Charles H. , Mejia Maria C.
Published: May 2024

Objectives

We explored temporal trends in drug-related infant deaths in the United States (U.S.) from 2018 to 2022.

Methods

We used data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (WONDER). A total of 295 drug-involved infant deaths were identified from 2018 to 2022 (provisional mortality data for year 2022) based on the underlying cause of death.

Results

In the U.S. from 2018 to 2022, there was a significant 2.2-fold increase in drug-involved infant mortality. The observed increases were higher in non-Hispanic White and Black infants. The findings show that drug-involved infant deaths were more likely to occur in the postneonatal period, defined as ages 28–364 days (81.4 %) compared to the neonatal period. The most prevalent underlying causes of death included assault (homicide) by drugs, medicaments and biological substances (35.6 %) followed by poisoning due to exposure to narcotics and psychodysleptics (hallucinogens) (15.6 %). The most common multiple causes of drug-involved infant deaths were psychostimulants with abuse potential of synthetic narcotics.

Conclusions

Drug-related infant mortality has increased significantly from 2018 to 2022. These increases are particularly evident among White and Black infants and occurred predominantly in the postneonatal period. These findings require more research but also indicate the need to address drug-involved infant deaths as preventable clinical and public health issues. Effective strategies to reduce drug-involved infant deaths will require preventing and treating maternal substance use disorders, enhancing prenatal care access, and addressing broader social and behavioral risk factors among vulnerable maternal and infant populations.
Cost-effectiveness of ambroxol in the treatment of Gaucher disease type 2
Authors: Milosavljević Miloš N. , Gutić Medo , Janjić Vladimir , Veselinović Slađana , Djordjić Milan , Ivanović Radenko , Milosavljević Jovana , Janković Slobodan M.
Published: May 2024

Objective

Our aim was to compare the costs and efficacy of ambroxol in combination with imiglucerase with the costs and efficacy of imiglucerase only in the treatment of Gaucher disease type 2 (GD2) in the socio-economic settings of the Republic of Serbia, an upper-middle-income European economy.

Methods

The perspective of the Serbian Republic Health Insurance Fund was chosen for this study, and the time horizon was 6 years. The main outcomes of the study were quality-adjusted life years gained with ambroxol + imiglucerase and comparator, and direct costs of treatment. The study was conducted through the generation and simulation of the Markov chain model. The model results were obtained after Monte Carlo microsimulation of a sample with 1,000 virtual patients.

Results

Treatment with ambroxol in combination with imiglucerase was cost-effective when compared with imiglucerase only and was associated with positive values of net monetary benefit regardless of the onset of the disease. Such beneficial result for ambroxol and imiglucerase combination is primarily driven by the low cost of ambroxol and its considerable clinical effectiveness in slowing the progression of neural complications of GD2.

Conclusion

If ambroxol and imiglucerase are used in combination for the treatment of GD2, it is more cost-effective than using imiglucerase alone.
Trajectory mapping of renal clear cell carcinoma transcriptomes identifies stage-independent predictors of favorable prognosis
Authors: Sheng Jie , Zheng Zihan , Li Xuejuan , Li Meijing , Zheng Feng
Published: May 2024

Objectives

The prognosis of clear cell renal cell carcinoma (ccRCC) is typically based on clinical stage, but it can vary for some patients. Transcriptomic analysis is vital for understanding ccRCC progression, though its correlation with the clinical stage in predicting prognosis is uncertain. We aim to employ trajectory inference to study ccRCC’s molecular progression and identify potential new markers for judging disease progression and prognosis.

Methods

Using a trajectory inference approach, we characterize the molecular progression profile of ccRCC based on transcriptome profiling. Additional pathway activity, immune response, and miRNA profiling scoring were integrated to identify possible drivers of trajectory progression.

Results

Scoring based on the trajectory demonstrates a significant improvement in patient prognosis prediction and identifies 10 risk factors in patients with low-grade tumors, and nine protective factors in patients with high-grade tumors. Mechanistically, we demonstrate an association between solute light carrier transporters are associated with ccRCC progression, with SLC7A5 expression being validated through immunohistochemistry to increase in metastatic patients.

Conclusions

Trajectory analysis of ccRCC transcriptomes can be used to model the molecular progression of disease and may assist in ccRCC prognosis. SLC7A5 is aberrantly expressed in ccRCC and may be a risk factor for poor prognosis.
Was wissen wir über die psychische Gesundheit von Studierenden in Deutschland?
Authors: Gusy Burkhard , Lesener Tino , Opper Felix , Wolter Christine
Published: May 2024

Bundesweite, belastbare Daten zum Thema Gesundheit bei Studierenden gibt es seit dem Projekt „Gesundheit Studierender in Deutschland 2017“. Weitere aktuellere hochschulübergreifende Befragungen lassen folgenden Trend erkennen: Der Anteil Studierender mit (sehr) guter Gesundheit hat sich deutlich verringert, die Anteile Studierender mit depressiven Symptomen sowie hoher (emotionaler) Erschöpfung sind größer geworden. Ob diese Entwicklungen (ausschließlich) der COVID-19-Pandemie zuzuschreiben sind, ist offen.
Studierendengesundheit und das Potenzial der Gesundheitsressource Naturerfahrung
Authors: Laemmert Pia , Laemmert Philipp , Tittlbach Susanne
Published: May 2024

Unterschiedliche Herausforderungen im Studienalltag bewirken, dass sich Studierende psychisch belastet fühlen. Auf Basis des salutogenetischen Ansatzes müssen Ressourcen identifiziert werden, die bei der Belastungsbewältigung unterstützen. Die Ergebnisse der Gesundheitsumfrage an der Universität Bayreuth zeigen, dass Frauen und Studierende im zweiten Studienjahr besonders belastet sind. Naturaufenthalte werden von den Studierenden als mögliche Belastungsbewältigung wahrgenommen und eingesetzt.
Studierende mit gesundheitlicher studienerschwerender Beeinträchtigung
Authors: Gerdes Frederike , Schwabe Ulrike , Steinkühler Julia , Kroher Martina
Published: May 2024

Der Beitrag nimmt Studierende mit gesundheitlicher studienerschwerender Beeinträchtigung an deutschen Hochschulen in den Blick. Mit Daten von „Die Studierendenbefragung in Deutschland: best: Studieren mit gesundheitlicher Beeinträchtigung“ werden Ergebnisse zur Zusammensetzung, zur Studienabbruchintention sowie zu Diskriminierungserfahrungen von Studierenden vorgestellt. Innerhalb dieser Gruppe zeigen sich beachtenswerte Unterschiede nach Art und Ausmaß der studienerschwerenden Beeinträchtigung.
Ansatzpunkte und Herausforderungen für ein ganzheitliches studentisches Gesundheitsmanagement an Hochschulen
Authors: Schäfer Markus , Dietz Pavel , Reichel Jennifer
Published: May 2024

Studierende sind eine wichtige Zielgruppe der Prävention und Gesundheitsförderung und als zukünftige Führungskräfte zentrale Multiplikatoren für das Thema Gesundheit in der Gesellschaft. Der Beitrag gibt einen Überblick über wichtige Gesundheitsaspekte bei Studierenden und deren Einflussfaktoren und zeigt Ansatzpunkte und Herausforderungen für ein evidenzbasiertes, ganzheitliches studentisches Gesundheitsmanagement an Hochschulen auf.
Digitale Inklusion an Hochschulen
Authors: Fisseler Björn
Published: May 2024

Digitale Inklusion an Hochschulen ist mehr als nur digitale Barrierefreiheit. Der Beitrag beleuchtet daher vier Dimensionen digitaler Inklusion. Technisch barrierefreie digitale Bildungsangebote sind für Studierende mit Behinderungen ebenso wichtig wie die Berücksichtigung unterschiedlicher Zugangs- und Erfahrungsniveaus der Studierenden. Zusätzlich zur hochschuldidaktischen Gestaltung müssen Hochschulen eine Strategie mit klaren Standards und gezielter Personalentwicklung erarbeiten.
Gesunde Hochschullehre – ein Paradigmenwechsel
Authors: Rupp Robert , Bucksch Jens
Published: May 2024

Gesundheitsförderung in der Hochschullehre wird traditionell nicht über einen didaktisch-pädagogischen Ansatz gewählt und geht mit einem Zusatzaufwand und Zeitverlust für den Bildungsauftrag einher. Im Paradigma einer guten gesunden Hochschullehre bleibt der Bildungsauftrag zentral und integriert Gesundheit beiläufig. Gesundheit wird in didaktischen Überlegungen zielführend eingebunden. Konzepte wie Stealth Interventions und Bedürfnisorientierte Hochschullehre bieten einen Orientierungsrahmen.
Präventionsbedarfe von Studierenden nach dem Gesundheitsstatus
Authors: Arnold Julia , Hollederer Alfons
Published: May 2024

In der Literatur ist wenig über die Bedarfe zur Gesundheitsförderung von Studierenden mit Gesundheitsbeeinträchtigung bekannt. Im März 2022 wurden Studierende mit und ohne gesundheitliche Beeinträchtigungen an der Universität Kassel zu verhaltens- und verhältnispräventiven Bedarfen befragt. Sie wünschen verstärkt Angebote zur psychischen Gesundheit sowie Verbesserung struktureller Bedingungen. Es empfiehlt sich der Aufbau eines studentischen Gesundheitsmanagements unter Berücksichtigung von beeinträchtigungsspezifischen Bedarfen.
Bewegungsaktivierung und Sitzzeitreduzierung im Hochschulalltag
Authors: Möckel Juliane , Wallmann-Sperlich Birgit , Rupp Robert , Bucksch Jens
Published: May 2024

Studierende sind durch langes Sitzen im Hochschulalltag gesundheitlichen Risiken ausgesetzt. Die Hochschullehre stellt einen vielversprechenden Ansatz für eine Reduzierung der Sitzzeiten und gleichzeitiges Fördern des Lernens durch bewegte Lehre und Studienzeiten dar. Interventionen sollten individuelle mit umwelt- und organisationsbezogenen Ansätzen koppeln. Projekte wie das Heidelberger Modell der bewegten Lehre und das Forschungskolleg Corpus zeigen innovative Ansätze im Bildungskontext auf.
PREGNANCY RATE AND NUMBER OF FETUSES OF WHITE-TAILED DEER RELATED TO BODY MEASUREMENTS AND SERUM METABOLITES
Authors: Rodríguez-Huerta Francisco A. , García José E. , Angel-García Oscar , Contreras Viridiana , Mellado Jesús , Mellado Miguel
Published: May 2024

This study aimed to assess the association between fertility and the number of fetuses of free-ranging concentrate-supplemented white-tailed deer (Odocoileus virginianus, texanus, Mearns 1898) from northern Mexico (27 °N) with body measurements and serum metabolites indicative of nutritional status. We studied 119 female deer (31 yearlings and 88 adults) captured in January 2021 using a net gun fired from a helicopter. Ultrasound scanning showed 100 and 97.8 % pregnancy rate and 1.52 ± 0.51 and 1.50 ± 0.59 fetuses/pregnant doe for yearlings and adult does, respectively, with no difference (p > 0.05) between age classes Thoracic circumference (cm) was higher (85.9 ± 4.9 vs. 84.1 ± 4.2; p = 0.039) for does carrying twins vs. singles. None of the serum metabolites indicative of nutritional status affected the fetal number of pregnant does. It was concluded that free-ranging white-tailed deer receiving concentrate supplementation in winter on a semi-arid rangeland has a high reproductive potential. Also, these results indicate that variation in maternal age within this population was not a significant driver of reproductive metrics of white-tailed deer. The plane of nutrition used in the present study was reflected in adequate serum metabolites indicative of nutritional status. Also, thoracic circumference may have prognostic value as a physical marker of multiple fetuses in female white-tailed deer.
WING PHENOTYPIC DIVERSITY IN STINGLESS BEES GENERA (APIDAE: MELIPONINI) FROM ECUADOR AMAZONIA
Authors: Bonilla Farinango Karen Vanessa , Liria Salazar Jonathan , Rasmussen Claus
Published: May 2024

Native stingless bees, Meliponini, are the only social bees that produce honey in addition to honeybees. These bees have been managed in meliponiculture and for crop pollination. In Ecuador, meliponiculture studies are scarce and limited by the lack of species recognition. Traditionally the taxonomic recognition of the species is based on morphological characteristics. In Hymenoptera, the wing shape has proven to be a valuable tool in combination with traditional characters. Due to this, the wing shape was evaluated for discriminating morphospecies in Ecuador’s Amazonian meliponaries. A total of 127 specimens grouped into six genera were analyzed: Melipona (Melikerria) sp., Melipona (Michmelia) sp1., Melipona (Michmelia) sp2., Tetragonisca sp., Paratrigona sp., Nannotrigona sp., Scaura sp., and Plebeia sp. The most significant differences are located at the vein intersection: cubital and cubital 1 (Cu + Cu1), posterior margin of the marginal cell (r and Rs), and basal and posterior marginal cell (M and Rs).
METODOLOGÍAS PARA EL ESTUDIO DE LAS INTERACCIONES PROTEICAS Y APLICACIONES EN EL CASO DE LA RELACIÓN PLANTA-BACTERIA
Authors: López Carrascal Camilo Ernesto
Published: May 2024

La maquinaría que permite el correcto funcionamiento celular involucra principalmente proteínas. Para cumplir con sus actividades, las proteínas establecen interacciones entre ellas. Para su estudio se han empleado principalmente las técnicas de doble híbrido de levaduras, co-immunoprecipitación, GST pull-down, localización celular, BiFC y FRET. En esta revisión se presenta una descripción de estas metodologías. Además se presenta, a manera de caso de estudio, una breve descripción de cómo la aplicación de estas metodologías ha permitido ahondar en el conocimiento de los mecanismos que se activan durante la relación que establecen las plantas con las bacterias fitopatógenas.
Ablation reduces androgyny and improves flowering and bunch production in palms of Coarí x La Mé hybrid (Elaeis oleifera x Elaeis guineensis)
Authors: Rodríguez Rivera Daniel David , Contreras Baños Ángel , Restrepo-Díaz Hermann , Cayón Salinas Daniel Gerardo
Published: May 2024

The first inflorescence in OxG hybrids after transplant to the field is often androgynous and should be removed to stimulate the initial vegetative growth of palms. The objective of this study was to evaluate the effects of early inflorescence ablation on later inflorescence emission and normal bunch development. The experimental design was completely randomized with two treatments (with early ablation and without ablation), four replicates, and 16 palms per replicate. The emission of female, male, and androgynous inflorescences, the number of leaflets, leaf area and dry weight of leaf 17, number of normal bunches formed, and annual production were estimated. The emission of normal female inflorescences increased with total ablation, while androgynous inflorescences increased without ablation. Ablated palms increased their leaf area, leaf dry weight, and annual bunch production.
Producción científica sobre el abordaje de la fricción en ortodoncia. Estudio de revisión con indicadores bibliométricos
Authors: Jaimes–Monroy Gustavo , Castro-Uribe Michelle Yesenia , Beltrán-Otero Brenda
Published: May 2024

Objetivo: analizar la producción de literatura científica respecto a la fricción en ortodoncia en los últimos 10 años, a través del estudio de indicadores bibliométricos, tales como: producción anual de artículos, revistas; autores, cooperación entre autores, países que cooperan, instituciones asociadas a las investigaciones, análisis de citas y co-ocurrencia. Métodos: se realizó un estudio bibliométrico descriptivo, retrospectivo de las bases de datos Web of Science y Pubmed, con una ventana de tiempo de 2010 a 2019. Luego de identificar todos los artículos sobre fricción en ortodoncia, se revisaron las variables de producción anual de artículos, revistas, autores, cooperación, países, instituciones, análisis de citas y co-ocurrencia. Para el análisis se utilizó Excel 2013 y VOSviewer 1.6.15, este último es un software gratuito para el análisis de datos bibliométricos. Resultados: para ambas bases de datos, el año de mayor producción en el tema fue 2015; la revista identificada con mayor cantidad de artículos fue Angle Orthodontics; Bourauel Christoph es el principal autor. Brasil fue el país con más publicaciones asociadas a este tema. Las instituciones que más publicaron para Web of Science y Pubmed fueron la Universidad de Bonn y la Universidad Nacional de Seoul. Respecto al análisis de co-ocurrencia, en ambas bases se encontró como variable común el bracket de autoligado, movimiento, tratamiento, sistema, y superficie. Conclusión: la actual producción de publicaciones sobre la fricción en ortodoncia indica una pobre producción de publicaciones en la temática. De esta manera, se destaca que la investigación en fricción sigue en desarrollo gracias a un grupo mínimo de científicos productivos que abordan aspectos que podrían ser de interés para otros investigadores.
Impacto socioeconómico de la COVID-19 en el escenario mexicano
Authors: Orellana-Centeno José Eduardo , Guerrero–Sotelo Roxana Nayeli
Published: May 2024

El SARS-CoV-2, causante de la infección viral y la enfermedad por coronavirus que ha provocado una pandemia, ha dejado, después de 18 meses, casi 230 mil muertes en México, el cuarto país más afectado en términos de mortalidad absoluta después de Estados Unidos, Brasil e India (1). A su vez, América Latina ha sido una región duramente golpeada, países como Brasil y México encabezan la lista en términos de mortalidad. El reporte de datos clínicos de estos países es aún incompleto. Por lo tanto, este ensayo tiene como objetivo presentar el impacto socioeconómico de la COVID-19 en el escenario mexicano. Los hallazgos demostraron que se requiere implementar modelos de interconexión para poder detectar vulnerabilidad y fuentes de resiliencia, un mecanismo que activaría la ayuda y las redes de apoyo. En ese sentido, es relevante desarrollar la capacidad para ver por los demás y la capacidad de ser solidarios. En conclusión, el resultado de las muertes en México no refleja solamente la acción del gobierno, la población o algún otro. Cada uno de los componentes que conforman el país son responsables de esta pandemia y cada quien deberá ejercer corresponsabilidad. Corregir, mejorar y ser solidario es el camino para superar la pandemia.
Somatic embryogenesis, plant regeneration and acemannan detection in aloe (Aloe barbadensis Mill.)
Authors: Garro-Monge Giovanni , Gática-Arias Andrés M. , Valdez-Melara Marta
Published: May 2024

La presente investigación tuvo como objetivo la regeneración de plantas de aloe (Aloe barbadensis Mill.) vía embriogénesis somática. Para la desinfección de los explantes se evaluó 2, 3, 4, 5, 10 y 15 min de sonicación en combinación con 4% v/v de NaOCl. El mayor porcentaje de sobrevivencia (85%) y de menor contaminación (15%) se logró con 5 min de sonicación. Se obtuvo callos embriogénicos friables a partir de meristemos apicales, bases de hojas jóvenes y embriones cigóticos. El mejor explante para la inducción de callos embriogénicos fue la base de hojas jóvenes con 89%, cultivadas en el medio complementado con 2,5 mg.l-1 de 2,4-D, 2 mg.l-1 de BAP y 40 mg.l-1 de sulfato de adenina. El mayor número de brotes se obtuvo a partir de callos embriogénicos producidos de embriones cigóticos, en el medio con 0,05 mg.l-1 de 2,4-D y 2 mg.l-1 de BAP. El análisis de cromatografía líquida de alta resolución (HPLC) reveló que la concentración de acemanan en callos embriogénicos (0,8-2,1 mg.ml-1) fue menor en comparación con la de hojas frescas (85 mg.ml-1). El protocolo de cultivo establecido en la presente investigación puede ser utilizado tanto para la propagación como para la transformación genética.
Effect of BAP and IAA on shoot regeneration in cotyledonary explants of Costa Rican melon genotypes
Authors: Valdez-Melara Marta , Gatica-Arias Andrés M.
Published: May 2024

Efecto del BAP y el AIA en la regeneración de brotes a partir de explantes cotiledonares de genotipos de melón costarricense. Para establecer una metodología para la regeneración del melón criollo (Cucumis melo L), se investigó la influencia del genotipo (OSO-1, OSO-2, OSO- 3, PQRG-1, PQRG-2, PQRG-3, y EM-1) y la interacción de N6-bencilaminopurina (BAP) (0,1, 0,5 y 1,0 mg.l-1) con ácido indolacético (AIA) (0, 0,05 y 0,5 mg.l-1) en la inducción de brotes y regeneración de plantas. Independientemente de la concentración de BAP y AIA, el mayor porcentaje de formación de brotes se obtuvo en EM-1>OSO- 1>PQRG-3>OSO-2>PQRG-2>PQRG-1>OSO-3. Por otra parte, independientemente del genotipo, el mayor porcentaje de formación de brotes se obtuvo con 0,5 mg.l-1 BAP y 0,05 mg.l-1 AIA o 1 mg.l-1 BAP y 0 mg.l-1 AIA. El protocolo de cultivo in vitro establecido puede ser utilizado para la micropropagación de genotipos “criollos” de melón.
La Regencia Agropecuaria en Costa Rica
Authors: Rojas-Cabezas Edgar
Published: May 2024

Hace más de 40 años el Colegio de Ingenieros Agrónomos de Costa Rica realiza una importante contribución al desarrollo del modelo costarricense de Regencias Agropecuarias, que se refleja, a nivel nacional, en aspectos como legislación, capacitación, implementación, seguimiento y fiscalización del proceso. El análisis del sistema de la "Regencia Agropecuaria Costarricense", representa una excelente oportunidad para examinar y comprender no sólo el proceso que lleva a cabo el Colegio de Ingenieros Agrónomos, sino también la figura técnica del Regente, encargada de velar porque las actividades del establecimiento regentado se sujeten a la normativa vigente en su relación con la sociedad. En el sistema Regencial Costarricense hay inscritos 791 establecimientos, que agrupados en 7 categorías regenciales diferentes brindan empleo a 533 profesionales, en quienes recae la responsabilidad técnica del regentado. En Costa Rica, el tema de Regencias Agropecuarias, corresponde a un modelo consolidado a lo largo del tiempo, que es mejorable, y que también se desea difundir, para que otros países del área lo tomen como guía, que adaptada a sus necesidades sirva para subsanar vacíos técnicos y legales presentes en la actividad agropecuaria local, para lo cual el Colegio de Ingenieros Agrónomos de Costa Rica pone a disposición regional su experiencia, de más de 4 décadas en la implementación del sistema.
Strange a construction: The “A egy N” in Hungarian
Authors: Fejes László , Molnár Cecília Sarolta , Sass Bálint
Published: May 2024

The paper gives a detailed description of the “A egy N” construction in Hungarian based on a thorough investigation of carefully collected corpus data. Utterances containing this construction express a speaker-related (mostly derogatory, but sometimes appreciative) value judgement. The morphological, syntactic, and pragmatic characteristics of the construction are presented. Furthermore, some formally and pragmatically similar constructions are also discussed and some misleading pieces of information in the earlier literature are debunked.