bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction of iron deficiency in patients with abnormal uterine bleeding
Authors: Ozolinya Lyudmila A. , Savchenko Tat’yana N. , Golovko Elizaveta D.
Published: September 2022

INTRODUCTION: Iron deficiency (ID) occurring latently or as iron deficiency anemia (IDA) is common in gynecology, particularly in patients with abnormal uterine bleeding (AUB).
AIM: We aimed at exploring the efficiency of a medication containing ferrous sulfate and multivitamins for the correction of latent ID and treatment of mild IDA in AUB patients.
MATERIALS AND METHODS: We performed a comprehensive clinical, laboratory, and instrumental examination of 60 women aged 35 to 50 years with AUB, revealing many gynecological pathologies (endometrial polyps or hyperplasia, ade nomyosis, and uterine myoma). The examined patients with AUB were divided into two groups: women with latent ID (group 1, n=38) and women with IDA (group 2, n=22). Moreover, all the patients had extragenital pathology in addition to gynecological diseases. As a treatment, ferrous sulfate with multivitamins was prescribed for 13 months.
RESULTS: Before treatment, the hemoglobin level in the examined patients ranged from 95 to 130 g/L, with an average of 127.11.8 g/L in group 1 and 100.32.1 g/L in group 2. Serum iron concentrations in the examined groups were 9.80.2 and 6.91.3 mol/L, respectively. After treatment, the average levels of hemoglobin and serum iron increased significantly and reached normal levels in all those examined. Hemoglobin was 143.31.8 g/L in group 1 and 122.51.5 g/L in group 2, whereas serum iron was 14.90.2 mol/L in group 1 and 13.51.0 mol/L in group 2. Furthermore, a significant increase to normal values was observed in other indicators of complete blood count and biochemical analysis.
CONCLUSIONS: The results of the study reveal a high clinical efficiency of ferrous sulfate and multivitamins in the treatment of ID in patients with AUB.
A social-cognitive research on metaphor and metonymy: Taking age appellations in Chinese as an example
Authors: Zheng Yan
Published: September 2022

The process from individual language to communal language, from individual experience to communal embodiment, and from individual cognition to collective cognition is based on human embodiment and social interactions. Metaphor and metonymy are two basic cognitive approaches to the world. Thus, human cognition is metaphorical and metonymic in essence, and metaphonymy is embodied and social in nature. In the perspective of social embodied cognition, this paper, taking social metaphonymy as a theoretical foundation and the Chinese age appellations as the corpus, demonstrates that Chinese age appellation has eight metaphonymic categories, namely, physiology, gender, wisdom, accessories, raising, behavior, animal and plant, and number. The paper, by expounding the embodiment and metaphonymy, aims to reveal metaphonymic cognitive mechanism of Chinese age appellations.
The developmental trajectory of mandarin Chinese-speaking children’s pure metonymy comprehension ability
Authors: Xie Songqiao
Published: September 2022

This empirical study investigates Chinese children’s developmental trajectory of pure metonymy comprehension. In the light of the experiment design in Jiang’s (2019) and Köder and Falkum’s (2020) studies, the present study, adopting a quantitative approach, employed a modified behavioral experiment and an eye-tracking experiment. Drawing on the experimental data, the study finds that: a) children’s metonymy comprehension performance showed a tendency towards the U-shape in the behavioral experiment tasks; b) children’s target (metonymy) fixation proportion, however, developed with age in the eye-tracking tasks; c) children’s metonymy comprehension not only developed with age but also showed different features in different difficulty levels of metonymies. Thus, this study explains the U-shape by arguing that age-4 and -5 children’s pure metonymy comprehension ability can be masked not only by a literal preference reported in Köder and Falkum’s (2020) study but also by the high randomness of task results of the age-3 participants and the high level of difficulty of culture-related metonymies. Moreover, the study also argues that year six is a crucial stage for children’s metonymy comprehension development, which provides implications for children’s early figurative language education.
A semantic contrastive study of Chinese and English verb “跑/run” from the perspective of cognitive semantics
Authors: Fang Peiyao , Liu Qi
Published: September 2022

Based on corpus data, this paper finds that the semantics of “跑/run” have similarities, which lie in the consistency of the central meanings and common usages. The differences are: 1) the meanings of “run” are significantly more than those of “跑”, resulting in a great divergence in the numbers of meanings; 2) compared with “跑”, the implications of “run” display a higher level of specificity. On the basis of cognitive theories, the paper has yielded the following findings. The semantic overlaps of “跑/run” root in their identical prototypical meanings. The semantic differences are generated by the following factors: 1) the image-schema distribution of “run” is wider with more abstract representations than that of “跑”, due to which many unique semantic items come into being; 2) semantic systems of “跑/run” adopt different metaphorical methods, contributing to more comprehensive cognitive domains of the semantic mapping and closer semantic interrelations of “run” than those of “跑”.
The L3 acquisition of English tense-aspect system by Uygur speakers with L2 Mandarin Chinese
Authors: Gu Qianping , Adil Muradil
Published: September 2022

This paper examines the role of Lexical Aspect Hypothesis (LAH) and linguistic typological similarity in the L3 acquisition of English tense and aspect among Uygur speakers with L2 Mandarin Chinese (Chinese hereafter). LAH asserts that the emerging verbal inflections at the early stage of language acquisition primarily function as markers of the lexical aspect and thus predicts universality for acquisition of tense and aspect. However, with an assumption of language transfer, the typological closer relationship of Uygur with English in terms of the tense and aspect system was expected to trigger L1 transfer in L3 acquisition. The study analyzed the English tense and aspect forms used by the participants (N = 25) for verbs of four distinct lexical aspects (50 target items) in contexts of past. The result shows that the lexical aspect influences the appropriate use of past tense—past tense marker aligned with telic predicates (achievements and accomplishments), -ing with activities (for inappropriate uses), and nonpast with states (for inappropriate uses), and the influence is observed at each proficiency level. The results show little evidence for language transfer in the acquisition of the English past tense, either from L1 Uygur or L2 Chinese; instead, the data suggest that L3 acquisition of tense and aspect is more subject to acquisitional universality (LAH).
The development of Chinese university students’ intercultural competence in a short-term study-abroad program
Authors: Zuo Hongshan , Hu Yaning
Published: September 2022

With increasing internationalization in higher education, more and more Chinese universities are providing students with exchange programs in cooperation with foreign universities. Hitherto, however, research about Chinese university students’ intercultural competence in a study-abroad context has been relatively rare. The present study, adopting a mixed-method research design, examines the development of Chinese students’ intercultural competence in a short-term study-abroad program, as well as the factors that might have a role to play in the process. It is found that the students made significant progress in intercultural competence after participating in the program and factors such as attitudes towards intercultural communication, cultural knowledge storage, English language proficiency and engagement in intercultural communication are important contributors to the development of intercultural competence in a short-term study-abroad context.
3D-Printed Gelatin-Alginate Hydrogel Dressings for Burn Wound Healing: A Comprehensive Study
Authors: Fayyazbakhsh Fateme , J. Khayat Michael , C. Leu Ming
Published: September 2022

Burn wound treatment is still a clinical challenge due to the severity of tissue damage and dehydration. Among various wound dressings, hydrogel materials have gained significant attention for burn wound treatment in clinical practice due to their soothing and moisturizing activity. In this study, 3D-printed dressings were fabricated using clinically relevant hydrogels for deep partial-thickness burn (PTB) wounds. Different ratios of gelatin and alginate mixture were 3D-printed and examined in terms of rheological behavior, shear thinning behavior, mechanical properties, degradation rate, and hydration activity to tune the hydrogel composition for best functionality. The cell-laden dressings were bioprinted to evaluate the effect of the gelatin: alginate ratio on the proliferation and growth of human dermal fibroblasts. The present findings confirm that the higher alginate content is associated with higher viscosity and Young’s modulus, while higher gelatin content is associated with faster degradation and higher cell viability. Together, the 3D-printed dressing with 75% gelatin and 25% alginate showed the best tradeoff between mechanical properties, hydration activity, and in vitro biological response. Findings from in vivo test using the most effective dressing showed the positive effect of 3D-printed porous pattern on wound healing, including faster wound closure, regenerated hair follicles, and non-traumatic dressing removal compared to the non-printed hydrogel with the same composition and the standard of care. Results from this research showed that 3D-printed dressings with an adequate gelatin: alginate ratio enhanced wound healing activity for up to 7 days of moisture retention on deep PTB wounds.
¿Es posible el arbitraje de consumo para resolver las controversias entre empresas prestadoras de servicios públicos de telecomunicaciones y los consumidores?
Authors: Moscol Salinas Alejandro
Published: September 2022

El procedimiento administrativo de reclamación ha prevalecido como mecanismo de solución de las controversias entre las empresas operadoras de servicios públicos de telecomunicaciones y sus usuarios. Sin embargo, según la política pública de protección del consumidor establecida en el Código de Protección y Defensa del Consumidor, se pueden implementar mecanismos alternativos para una mejor tutela de los consumidores. En el presente trabajo se explora la posibilidad de que se implemente el arbitraje de consumo para resolver estas controversias, y se identifican las ventajas y las desventajas del modelo actual de reclamación administrativa y del arbitraje de consumo. Se abre un espacio académico cuyo objeto es mostrar que el modelo procedimental actual puede revisarse y que existen otras formas de solución de conflictos y tutela del consumidor.
An approach based on tf-idf metrics to extract the knowledge and relevant linguistic means on subject-oriented text sets
Authors:   Yaroslav-the-Wise Novgorod State University, Mikhaylov D. , Kozlov A. ,   Yaroslav-the-Wise Novgorod State University, Emelyanov G. ,   Yaroslav-the-Wise Novgorod State University
Published: September 2022

In this paper we look at a problem of extracting knowledge units from the sets of subject-oriented texts. Each such text set is considered as a corpus. The main practical goal here is finding the most rational variant to express the knowledge fragment in a given natural language for further reflection in the thesaurus and ontology of a subject area. The problem is of importance when constructing systems for processing, analysis, estimation and understanding of information represented, in particular, by images. In this paper, by applying the TF-IDF metrics to classify words of the initial phrase in relation to given text corpora we address the task of selecting phrases closest to the initial one in terms of the described fragment of actual knowledge or forms of its expression in a given natural language.
La Gestión Empresarial en el Marco de las Ideas Sobre Sostenibilidad, RSE y Grupos de Interés
Authors: Volpentesta Jorge Roberto
Published: September 2022

La responsabilidad social empresaria (RSE), concepto centenario, asume actualmente un importante papel en el mundo empresarial. Luego de que a sus contenidos fundamentales se les incorporasen conceptos de la teoría de los stakeholders y del desarrollo sostenible, se acrecentó su complejidad, así como también su interés académico y empresarial. Este trabajo refleja una investigación que busca analizar la evolución conceptual de los cuatro conceptos mencionados mediante revisión bibliográfica, complementándola con reflexiones sobre resultados de cuatro investigaciones de campo realizadas en empresas de la República Argentina. Luego de examinar las ideas iniciales desde sus orígenes y de constatar su mutua interrelación e interacción, se concluye que su combinación expresa una nueva orientación en la conducción de las empresas y representa el sustrato esencial que contiene las directrices clave de un nuevo paradigma de gestión socioambientalmente responsable y sostenible.
Effect of Tocilizumab Use on Mortality in COVID-19 Patients Admitted to Intensive Care Unit
Authors: TOSUN Mustafa , ÖLMEZ Hasan
Published: September 2022

Aim: Coronavirus disease 2019 (COVID-19) mostly proceeds with mild respiratory symptoms, but sometimes severe pneumonia, cytokine storm, and acute respiratory distress syndrome can develop. Anti-cytokine treatments are being tried for cytokine storm. In this study, we aimed to examine the effect of tocilizumab on mortality associated with COVID-19.
Material and Methods: The study included 146 patients with moderate-to-severe acute respiratory distress syndrome diagnosed with COVID-19. The patients were divided into two groups, receiving only standard treatment (ST group, n=44), and tocilizumab treatment in addition to standard treatment (TCZ group, n=102). Groups were compared in terms of demographic, clinic, and laboratory data. Also, mortality rates were determined to detect the effect of tocilizumab on mortality.
Results: Overall, 36.3% (n=53) of the patients were female, 63.7% (n=93) were male, and the mean age was 69.5±14.2 years. The mortality rate was 29.4% (n=30) in the TCZ group and 52.3% (n=23) in the ST group (p=0.009). While C-reactive protein, fibrinogen, and lactate levels on admission to the intensive care unit (ICU) were similar across the groups, the TCZ group had higher ferritin levels (p=0.006). On discharge from ICU, the TCZ group had a significant decrease in C-reactive protein (p<0.001), while their ferritin levels decreased to levels in the ST group (p=0.134). The absence of tocilizumab in the treatment regimen was associated with a 2.63-fold increase in the mortality risk.
Conclusion: Tocilizumab reduces the mortality in COVID-19 patients in ICU. However, further studies are warranted to better elucidate the efficacy and side effects of tocilizumab.
The Effect of Combination of Aerobic and Strengthening Exercise on Muscle Strength, Balance, and Sleep Quality in Individuals with Type 2 Diabetes
Authors: YILMAZ MENEK Merve , BUDAK Miray
Published: September 2022

Aim: The aim of this study was to determine the effects of aerobic and strengthening exercise combination on glycosylated hemoglobin (HbA1c), muscle strength, balance, and sleep quality in individuals diagnosed with type 2 diabetes mellitus (DM). Material and Methods: Fifty individuals aged between 30 and 65 years and diagnosed with type 2 DM were included in this study. Anthropometric measurements, HbA1c, quadriceps and hamstring muscle strength, balance, and sleep quality of the included individuals were evaluated. Aerobic and strengthening exercises were applied to the participants 3 days a week for 12 weeks. All evaluation measurements were repeated at the end of 12 weeks. Results: Of the 50 individuals included in this study and diagnosed with type 2 DM, 64% (n=32) were male and 36% (n=18) were female. The mean age of the participants was 50.12±10.81 years, the mean body mass index was 29.97±3.12 kg/m2, the waist/hip ratio was 0.91±0.08, and the mean HbA1c was 9.19±2.39. When the pre and post-treatment HbA1c, muscle strength, balance, and sleep quality measurements of all participants were compared, there were statistically significant differences (p<0.001). Conclusion: It was determined that the combination of long-term aerobic and strengthening exercise decreased the HbA1c value and also significantly improved muscle strength, balance, and sleep quality in individuals with type 2 DM. A structured exercise program that includes strengthening and aerobic exercises would be beneficial in developing the most effective and appropriate exercise prescriptions in terms of exercise efficiency and sustainability for individuals with type 2 DM.
Risk factors for surgical site infection following craniotomy: a 10-year retrospective cohort study
Authors: Rowbottom Hojka , Hribernik Borut , Ravnik Janez
Published: September 2022

Namen: Kraniotomija je osnovni nevrokirurški pristop, ki je povezan z zapleti, med katere spada okužba kirurške rane, za pojav katere so dejavniki tveganja še vedno nepopolno definirani. Namen raziskave je bil prepoznati dejavnike tveganja za pojav okužbe kirurške rane pri odraslih bolnikih, operiranih na Oddelku za nevrokirurgijo Univerzitetnega kliničnega centra v Mariboru.

Metode: Izvedli smo retrospektivno kohortno študijo, v kateri smo analizirali podatke za obdobje od januarja 2009 do avgusta 2019. Primerjali smo podatke bolnikov, ki so razvili okužbo kirurške rane, s podatki tistih, ki okužbe niso razvili. 66 bolnikov je razvilo okužbo kirurške rane, v kontrolno skupino smo naključno uvrstili 70 bolnikov brez omenjene rane. V raziskavo smo vključili  le bolnike, ki so po opravljeni elektivni kraniotomiji potrebovali kirurško zdravljenje okužene kirurške rane.

Rezultati: Med 1192 bolniki, ki so v opazovanem obdobju imeli opravljeno kraniotomijo, je 66 (5,5 %) bolnikov razvilo okužbo kirurške rane. Najpogosteje je prišlo do razvoja osteomielitisa (66,7 %) in epiduralnega abscesa (63,6 %), najpogosteje izoliran povzročitelj pa je bil Propionibacterium acnes (54,5 %). V raziskavi so se kot dejavniki, povezani s pojavom okužbe kirurške rane, izkazali uporaba izdelka Surgicel® (p = 0,0019, Fisherjev natančni test), duralni nadomestki (p = 0,0028, Fisherjev natančni test), samolepilna dura (p = 0,0274, Fisherjev natančni test), zapiranje kože s šivi (p = 0,0001, Fisherjev natančni test), opravljena frontalna kraniotomija (p = 0,0328, Fisherjev natančni test) in pooperativno predpisovanje glukokortikoidov (p = 0,04, Fisherjev natančni test).

Zaključek: Z našo študijo smo prepoznali določene dejavnike tveganja, povezane s pojavi okužbe kirurške rane, ki jih lahko odpravimo in tako znižamo pojavnost tovrstnega operativnega zapleta oz. zaplet hitreje prepoznamo.
Understanding the molecular biology of avian viruses and their role in poultry health
Authors:   Mississippi State University, USA, Banda Alejandro
Published: September 2022

Different molecular aspects of avian viruses are presented such as the role and importance of capsid proteins and viral glycoproteins in viral pathogenesis, in development of diagnostic methods and the creation of recombinant vaccines is discussed. Mechanisms of viral evolution such as mutation, recombination and reassortment are included, and their role in the origin of diverse influenza, infectious bursal disease, avian reovirus is commented.
Energetyka obywatelska jako nowy etap rozwoju prawa energetycznego
Authors: Lissoń Piotr
Published: September 2022

Przedmiotem artykułu jest prawne wyodrębnienie energetyki obywatelskiej jako nowego podsektora energetycznego. Stworzenie odpowiednich warunków do jej rozwoju ma się przyczynić do osiągnięcia unijnych i krajowych celów związanych z transformacją energetyczną. Niniejsze opracowanie wyjaśnia pojęcie energetyki obywatelskiej, ukazuje jej cele, formy organizacyjne, przedmiot działalności, prawną niezależność od tradycyjnych przedsiębiorstw energetycznych oraz miejsce przepisów dotyczących tej dziedziny energetyki w aktach prawnych określających zasady funkcjonowania systemu energetycznego.
Quantos "modernismos" cabem numa modernidade?
Authors: Medeiros Afonso
Published: September 2022

Nas intenções deste breve texto, que pretende sublinhar algumas das concepções de moderno visíveis no recente debate sobre os modernismos, configura-se a hipótese de que alguns modernismos do início do século XX, inclusive aqueles aludidos pelo Manifesto Antropófago, fundam suas raízes numa anacronia identitária que atravessa a própria figuração da modernidade euro-ocidental desde o século XVI. Consequentemente, o presente (nos dois sentidos) do modernismo brasileiro seria uma tomada de consciência sobre nosso ser antropofágico, então considerado como herança indígena. Esse ser/estar modernista naquele presente teve, como veremos, um caráter tanto histórico quanto filosófico e estético, o que nos autorizaria a tentativa de compreender a modernidade do outro (europeu) a partir das entranhas da (anti)colonialidade de si. Para tanto, recorre-se a autores que teorizaram o moderno, tais como Oswald de Andrade, Benedito Nunes, Philadelpho Menezes e Philippe Dagen, dentre outros.
O monumento do “guerreiro guarani”
Authors: Lima da Silva Francislei Lima da
Published: September 2022

No dia 22 de abril de 1825, no quarto ano da Independência e do Império, o povoado de Conceição do Serro (Mato Dentro), Minas Gerais, inaugurou o chafariz coroado pela escultura de um indígena – “gênio do Brasil”. Tal monumento da água transformava o aspecto da praça pública daquele povoado ao reforçar e inserir no imaginário local a sua adesão ao jovem Império que se conformava a partir da Independência política em 1822. A presença do indígena alegorizado em gestos triunfantes e que enaltecia determinadas virtudes cívicas coexistia com as tensões e a violência imposta aos nativos que habitavam os campos de cerrado que davam nome àquele lugar. Entre os festejos da Independência e da adesão a d. Pedro enquanto monarca legítimo, os povos originários representavam um desafio a ser superado para a expansão do projeto “civilizador” imposto sobre aqueles que deveriam se submeter ao imperador. É preciso, portanto, perscrutarmos com maior cuidado aquela figura do indígena idealizado, alçado à símbolo da nação, feito de pedra adornada de plumas, brincos, colar e manto; um nativo imaginado tal qual o fora o Brasil que se conformava naquele momento, em meio a tantas guerras e disputas simbólicas sobre a antiga colônia que se fazia independente.
Notas sobre a encruzilhada
Authors: Porfírio Iago
Published: September 2022

Este texto tem por objetivo traçar uma reflexão sobre a exposição Encruzilhada, com curadoria do artista visual baiano Ayrson Heráclito e de Daniel Rangel, realizada no Museu de Arte Moderna da Bahia (MAM-BA), entre 18 de abril e 14 de agosto de 2022. Dedicada a Exu, a exposição nos oferece um percurso pelas encruzilhadas desse orixá, mensageiro entre o céu e a terra, e pela ancestralidade e imagens negro-africanas. O caminho argumentativo do texto baseou-se na visita à exposição, no catálogo da mostra e no diálogo com pesquisadores para uma leitura crítica acerca da potência política e fabulativa da imagem e de obras artísticas. Para tratar do trânsito exuístico entre mundos que a exposição convoca a participar, proponho uma reflexão acerca do modo como opera a noção de “encruzilhada-das-imagens”, que, tal como Exu, oscila entre a regra e o desvio, no diálogo com o regime estético e político da arte e sua forma inventiva de constituir cenas de dissenso e de “contra-história”.
Hubungan antara Asertivitas dengan Kekerasan dalam Pacaran pada Wanita Dewasa Awal
Authors: Pratita Hanindha Syasti , Herdiana Ike
Published: September 2022

Penelitian ini dilakukan untuk menguji secara signifikan hubungan antara asertivitas dengan kekerasan dalam pacaran pada wanita dewasa awal. Kekerasan dalam pacaran pada penelitian ini mengacu pada korban, baik kekerasan fisik, seksual, dan emosional atau verbal. Terdapat 104 responden dengan kriteria wanita, usia 18–25 tahun, pernah mengalami kekerasan dalam pacaran yang berpartisipasi dalam kuesioner online. Metode survei yang dilakukan dalam penelitian ini menggunakan Skala Asertivitas untuk mengukur asertivitas dan Skala The Revised Conflict Tactics Scale (CTS2) yang telah diadaptasi ke dalam bahasa Indonesia untuk mengukur kekerasan dalam pacaran. Hasil dari penelitian ini menunjukkan terdapat hubungan antara asertivitas dengan kekerasan dalam pacaran pada wanita dewasa awal. Hubungan antara kedua variabel menunjukkan nilai yang negatif, sehingga semakin tinggi asertivitas maka semakin menurunnya kekerasan dalam pacaran, dan semakin rendah asertivitas maka semakin meningkatnya kekerasan dalam pacaran.
Hubungan Kekerasan dalam Pacaran dengan Self-esteem pada Korban Wanita Dewasa Awal
Authors: Ramadhani Devia Putri , Herdiana Ike
Published: September 2022

Masa perkembangan pada dewasa awal sering kali menjalin hubungan berpacaran. Namun banyaknya kasus kekerasan dalam pacaran yang dapat memberikan dampak perasaan tidak berdaya menghadapi kekerasan dari pasangannya, merasa tidak berarti, dan memiliki self-esteem yang rendah. Penelitian ini bertujuan untuk mengetahui hubungan kekerasan dalam pacaran dengan self-esteem pada korban wanita dewasa awal. Sampel penelitian ini merupakan wanita dewasa awal korban kekerasan dalam pacaran (18-25 tahun). Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei yang melibatkan 106 responden. Data dikumpulkan menggunakan metode survei daring yang disebarkan melalui media sosial. Instrumen yang digunakan adalah CTS2 dan RSES. Hasil penelitian ini menunjukkan adanya hubungan yang negatif dan kuat antara kekerasan dalam pacaran dengan self-esteem pada korban wanita dewasa awal.
Hubungan antara Kecerdasan Emosional dengan Work-life Balance pada Karyawan Startup
Authors: Nugraha Gistha , Adiati Rosatyani Puspita
Published: September 2022

Tujuan dari penelitian ini adalah untuk mengetahui apakah kecerdasan emosional memiliki hubungan dengan work-life balance pada karyawan startup. Startup memiliki jam kerja yang fleksibel dan fast paced, sehingga waktu karyawan banyak dihabiskan untuk bekerja. Maka dari itu dibutuhkan kecerdasan emosional untuk dapat menentukan peran sesuai dengan situasi yang dibutuhkan. Meskipun begitu, terdapat penelitian lain yang memiliki hasil berlawanan. Metode yang digunakan adalah metode survei dengan teknik non-probability sampling dengan kriteria partisipan Warga Negara Indonesia, berdomisili di Indonesia, rentang usia 18 – 54 tahun serta bekerja di perusahaan startup. Alat ukur yang digunakan adalah The Assessing Emotions Scale (33 item) dan Work-life Balance Scale (17 item). Data dianalisis menggunakan Uji Korelasi Pearson product-moment. Hasil yang didapat adalah tidak terdapat hubungan yang signifikan antara kecerdasan emosional dengan work-life balance pada karyawan startup.
Hookworm in Stray Cats (Felis silvestris catus) as Cutaneous Larva Migrant Agent (CLM) in Humans
Authors: Mahendra Fadhil Ihsan , Soebaktiningsih Soebaktiningsih , Prabawati Risma Karlina
Published: September 2022

Highlights :

Risk factors that can increase the incidence of CLM in humans include male sex, children aged <15 years, low-income people, and daily behaviour of walking outdoors without using footwear, especially on the sand.
Risk factors that play the most role in increasing the incidence of CLM in humans are walking outdoors without using footwear, especially on the sand.

 
Abstract :
Cats arethe host of a wide variety of microorganisms including ectoparasites and endoparasites.One of theendoparasites that infect cats is hookworm. The hookworms consists of two groups, the animal hookworms, and the human hookworms. The manifestation that can be caused by animal hookworms to humans is Cutaneous Larva Migrant (CLM). This study aimed to discover whether hookworm in stray cats (Felis silvestris catus) can cause CLM in humans. We performed a systematic search in Pubmed/Medline and Cochrane published between 2016 and 2021 with no restrictions by language, research country, or type of research design . The results of the analysis showed that the high level of hookworms infection in stray cats could increase the risk of CLM in humans. Based on the study, we could conclude that the high prevalence of hookworm infection in cats plays an important role in the increased risk of zoonoses in humans which in turn could also increase the prevalence of CLM in humans.
Bacterial and Antibiogram Profile of Urinary Tract Infection Patients in Tertiary Hospital, Surabaya, Indonesia
Authors: Utami Mahrumi Dewi Tri , Wahyunitisari Manik Retno , Mardiana Nunuk , Setiabudi Rebekah Juniati
Published: September 2022

Highlights:

Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria.
Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem.
Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline,  teicoplanin, and ampicillin.

 
Abstract:
Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was a retrospective study using urine culture and antibiotic susceptibility test results obtained from Clinical Microbiology Laboratory in a tertiary general hospital in Surabaya, Indonesia for a two-month period patients. Most aged more than and/or equal to 59 years, in both sexes. Gram-negative bacteria, particularly , was being the most between June to July 2019. There were 215 patients with significant urine culture results of 54.4% from Escherichia coli female bacteria were carbapenem antibiotics and amikacin, while teicoplanin and vancomycin were some antibiotics susceptible to gramcommon bacteria that caused UTI, followed by K. pneumoniae. Some antibiotics with the highest susceptibility to gram-negative positive bacteria. This study result indicated that there was an urge to conduct local antibiogram profile investigation due to the low susceptibilities shown in recent empirical therapy recommendations, such as trimethoprim sulfamethoxazole, fluoroquinolone, nitrofurantoin, and fosfomycin.
Vascular Dementia Patients Characteristics With a History of Stroke in a National Brain Center Hospital Jakarta, Indonesia
Authors: Hanifah Afifah Kusuma , Astari Riezky Valentina , Muktamiroh Hikmah , Saleh Arman Yurisaldi
Published: September 2022

Highlights:

Characteristics of vascular dementia patients with a history of stroke was aimed.
The most characteristics of vascular dementia patients with stroke history are men, post-ischemic stroke, hypertension grade 1,  and lesions in the basal ganglia.

Abstract:
Stroke patients increase each year. Stroke is a cerebrovascular disorder caused by disruption of cerebral blood flow, which could reason vascular lesions within the mind parenchyma to be a threat to significant   disorders. One of them is vascular dementia. Each affected person is prone to growing dementia after a stroke in three to five instances. Thisstudy aimed to decide the traits of patients with vascular dementia with a record of stroke. This study used a descriptive retrospective approach with a cross-sectional method. The samples were obtained from the total sampling technique. The sample of the study was vascular dementia patients with a stroke record at the National Brain Center Hospital Prof. Dr. dr. Mahar Mardjono Jakarta in the period of 2020 through the inclusion standards with 191 samples. This study found that the majority of patients were males as many as 129 (67.5%), age group of 55-64 were 67 patients (35.1%), post-ischemic strokes were 164 patients (85.9%), grade 1 hypertension as many as 70 patients (36.6%), and basal ganglia as many as 76 patients (29.23%). Characteristics of vascular dementia patients with the maximum stroke records in men, aged 55-64 years, post-ischemic stroke, grade 1 hypertension, and a majority of the lesions within the basal ganglia.
Knowledge on The Risk of The Ischemic Heart Disease Estimation by WHO Charts in Cempaka Baru, Indonesia
Authors: Fitriani Hasna Luthfiah , DA Ridwan Karina Ajeng
Published: September 2022

Highlights:

The risk estimation of ischemic heart disease.
High blood pressure and cholesterol levels affect Ischemic heart disease.

 
Abstract:
In 2018, Indonesia became the country with the second-highest number of deaths and disabilities (DALYs) due to ischemic heart disease. Based on Riskesdas data in 2018, Jakarta is one of the provinces with a high percentage (1.9%) of ischemic heart disease. Risk factors for ischemic heart disease that are not treated quickly will increase the severity of ischemic heart disease in the future. Therefore, this study was to provide education regarding the assessment of risk estimation for ischemic heart disease with WHO/ISH charts among participants in Cempaka Baru sub-district. This study used pre-test and post-test questionnaires. After the seminars, the interview and examination results were carried out as well as calculating the estimated risk of ischemic heart disease using the WHO chart. These charts were divided into low risk (<10%), moderate (10-20%), and severe (>20%). The evaluation was conducted by comparing the pre-test and post-test results, which indicated that the knowledge level increased significantly from the Paired T-Test with a p-value = 0.000 (p<0.05). The significant estimation of high risk of ischemic heart disease for high blood pressure was 72.7% (p=0.023) and total cholesterol level was 66.7% (p=0.049). The increasing knowledge of the stratification risk of ischemic heart disease with the WHO chart was expected to reduce the risk of ischemic heart disease in the future.
Discovering Patterns of Cardiovascular Disease and Diabetes in Myocardial Infarction Patients Using Association Rule Mining
Authors: Singh Anju , Singh Divakar , Sharma Shikha , Upreti Kamal , Maheshwari Manish , Mehta Vimal , Sharma Jitender , Mehra Pratishtha , Dabla Pradeep kumar
Published: September 2022

Highlights:

Association Rule Mining tools predict the association of early-onset Myocardial Infarction with Hypertension and Diabetes Mellitus.
Association Rule Mining tools using clinical and biochemical attributes can predict the development of Hypertension and Diabetes Mellitus in Myocardial Infarction patients.

Abstract:
Cardiovascular diseases (CVDs) are a major cause of mortality in diabetic patients. Hypertensive patients are more likely to develop diabetes and hypertension contributes to the high prevalence of CVDs, in addition to dyslipidemia and smoking. This study was to find the different patterns and overall rules among CVD patients, including rules broken down by age, sex, cholesterol and triglyceride levels, smoking habits, myocardial infarction (MI) type on ECG, diabetes, and hypertension. The cross-sectional study was performed on 240 subjects (135 patients of ST-elevation MI below 45 years and 105 age matched controls). Association rule mining was used to detect new patterns for early-onset myocardial infarction. A hotspot algorithm was used to extract frequent patterns and various promising rules within real medical data. The experiment was carried out using "Weka'', a tool for extracting rules to find out the association between different stored real parameters. In this study, we found out various rules of hypertension like “Rule 6” says that if levels of BP Systolic > 131 mmHg, LpA2 > 43.2 ng/ml, hsCRP > 3.71 mg/L, initial creatinine > 0.5 mg/dl, and initial Hb ≤15 g/dl (antecedent), then the patient will have 88% chance of developing hypertension (consequent). Similarly for diabetes mellitus with finding their lift and confidence for different support like “Rule 6”, if MI type on ECG = ’Inferior Wall MI’ with STATIN=No, and levels of Triglycerides ≤325 (antecedent), then the patient had a 67% chance of developing diabetes mellitus. We concluded that early-onset myocardial infarction is significantly associated with hypertension and diabetes mellitus.Using association rule mining, we can predict the development of hypertension and diabetes mellitus in MI patients.
Risk Factors of Central Obesity in Indonesian Men: A Cross-Sectional Data Study of The Indonesia Family Life Survey 5 (IFLS 5)
Authors: Dahlia  , Pribadi Gracia Satyawestri , Martini Santi , Yi-Li Chung
Published: September 2022

Highlights:

Low levels o physical activity are the major risk factor of central obesity among Indonesian men.
There was a relationship between smoking status,  smoker type, cigarette type, physical activity, and meat consumption frequency and the incidence of central obesity.

 
Abstract:
Obesity is one of the leading health problems in both developed and developing countries. Central obesity can be defined as a condition where excess fat has accumulated in the abdominal area. There are several risk factors that may cause central obesity in men such as smoking habits, physical activity, and dietary habits. This study aimed to analyse the risk factors of central obesity in Indonesian men. This was an analytical observational study using a cross-sectional design. It used secondary data from the Indonesia Family Life Survey (IFLS 5) with a sample size of 4,648 respondents. The variables studied here were smoking status, type of smoker, type of cigarette, physical activity, and meat consumption frequency. Logistic regression analysis was used. The results of this study showed that the mean age of the respondents was 51 years old. There was a relationship between smoking status (p=0.000), type of smoker (p=0.002), type of cigarette (p=0.000), physical activity (p=0.000), and meat consumption frequency (p=0.024) and the incidence of central obesity. The conclusion of the study was that there was a relationship between smoking status, type of smoker, type of cigarette, physical activity, meat consumption frequency, and the incidence of central obesity, all of which were risk factors of central obesity in Indonesian men. A low level of physical activity was the most prominent risk factor associated with central obesity among Indonesian men. From this study, we suggested controlling the risk factors of central obesity by providing education on the dangers of smoking and the importance of physical activity and a balanced nutritional diet.
Durability of S-RBD IgG Antibody Levels after Sinovac Vaccination in Healthcare Workers
Authors: Nugraha Jusak , Permatasari Cynthia Ayu , Fitriah Munawaroh
Published: September 2022

Highlights:

The effectiveness of vaccination through the kinetics of the antibody response to the SARS-COV-2 vaccine administration by examining IgG S-RBD levels was aimed.
Two doses of the Sinovac vaccine formed antibodies in healthy individuals in the first 3rd month after vaccination.
An S-RBD IgG antibody in the 6th-month post-vaccination was significantly different between groups without a history and groups with a history of infection with COVID-19.

 
Abstract:
Since it was declared a pandemic in early 2020, Coronavirus Disease 2019 (Covid-19) has caused high morbidity and mortality in the world. In view of the urgency of the situation, vaccination efforts are needed to break the chain of disease transmission. Various types of vaccines have been successfully developed and obtained approval for emergency use. However, the effectiveness of these vaccines, both in the short and long term, has not been fully known. This study aimed to examine the effectiveness of vaccination through the kinetics of the antibody response to the administration of the SARS-COV-2 vaccine by examining IgG S-RBD levels. This study was an observational analytic study with a prospective cohort approach carried out between January and November 2021 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Fifty health workers who received Sinovac vaccination in as many as 2 doses underwent venous blood taking and measurement of quantitative S-RBD antibody level. Then, quantitative S-RBD IgG antibody levels were measured and recorded in each subject. The mean S-RBD IgG antibody was found to have fluctuation. The titer was found to significantly increase on day 14 and dropped significantly in month 3 (p <0.001). There was a significant difference in S-RBD IgG levels 6 months after vaccination between Covid-19 uninfected groups and Covid-19 infected groups (p <0.001). In a conclusion, two doses of the Sinovac vaccine formed antibodies, although humoral immunity obtained tended to decrease in 3rd month after vaccination to healthy individuals. The average level of S-RBD IgG antibody in the sixth month post-vaccination was found to be significantly different between groups without history and groups with a history of with infection COVID-19.
Spike-Receptor Binding Domain (SRBD) Antibodies Secretion in COVID-19 Survivors and Non-Survivors Post-Pre-Endemic Vaccination
Authors: Museyaroh  , Woelansari Evy Dyah , Kriharyani Dwi
Published: September 2022

Highlights

The research this for determine the presence of immune response post-vaccine
The results of this study indicate that there are differences in immune responses, in survivors patients have higher SRBD antibody levels than non-survivors

 
Abstract :
The development of a vaccine for SARS-COV-2 began in mid-2020 with the aim of stimulating an individual's immune response against SARS-CoV-2 infection. The purpose of this study was to determine the levels of post-vaccine SRBD antibody secreted in COVID-19 survivors and non-survivors. Antibodies are considered to play a more important role in evaluating immunity because antibody tests may provide information about a person's immune status against SARS-CoV-2. The study was conducted at Husada Utama Hospital, Surabaya, Indonesia, in April – May 2021. The samples were taken prospectively with a total sample of 60 patients, consisting of 40 non-survivors and 20 survivors of COVID-19 who had received Sinovac vaccine doses 1 and 2. Examination of Sars-CoV-2 SRBD antibody was conducted by using CL series of Mindray device by means of CLIA method. The average level of antibody was assessed in each sample group and the results were subjected to the Mann Whitney test. The mean SRBD antibody level in female patients was 428.24 ± 271.25, while in male patients it was 310.40 ± 113.71 U/mL. The results of the Mann Whitney test revealed a P-Value of 0.09 > 0.05, indicating no difference in post-vaccine SRBD antibody levels between females and males, but there were differences in SRBD antibody levels in COVID-19 survivors and non-survivors with a P-Value of <, i.e. 0.00 < 0.05 There was no difference in post-vaccine SRBD antibody levels between females and males in COVID-19 survivors and non-survivors, but there were differences in post-vaccine antibody levels between COVID-19 survivors and non-survivors.
Intervensi Analisis Lirik: Mengatasi Ruminasi Kognitif Remaja Akhir Perempuan dengan Lirik Lagu BTS
Authors: Yuniswara Ernestine Oktaviana , Hartini Nurul
Published: September 2022

Kecenderungan remaja perempuan melakukan ruminasi kognitif meningkat pada masa pandemi COVID-19, yang pada akhirnya dapat memunculkan gangguan kecemasan dan depresi. Intervensi Analisis Lirik dalam kelompok untuk mengarahkan pemikiran dan memperkenalkan mekanisme koping yang lebih efektif dapat menjadi salah satu metode Terapi Kognitif Perilaku dalam mengatasi ruminasi kognitif. Dalam laporan ini, karakteristik anggota kelompok intervensi sebagai penggemar musisi Korea Selatan BTS (Bangtansonyeondan) melandasi pemilihan lagu. Mendiskusikan lagu “Permission to Dance” dengan lirik yang optimis memberikan tilikan (insight) mengenai strategi koping positif dan efektif yang dapat dilakukan alih-alih melakukan ruminasi kognitif. Hasil penelitian ini menyarankan bahwa kombinasi Intervensi Analisis Lirik dengan psikoedukasi dan penugasan pengamatan diri secara mandiri dapat menurunkan gejala depresi, kecemasan, dan stres partisipan.
Cancer stem cell-mediated therapeutic resistance in hepatocellular carcinoma
Authors: Li Mei-Mei , He Yi-Ti , Liang Jie-Kai , Guan Xin-Yuan , Ma Ning-Fang , Liu Ming
Published: September 2022

Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing evidence indicates that cancer stem cells (CSCs) are the major source of tumor heterogeneity. Hence, uncovering the resistance mechanisms associated with CSC properties is essential for developing effective therapeutics. CSCs resemble embryonic stem cells. Embryonic development-related genes and signaling pathways are usually abnormally active and function as oncofetal drivers in HCC. Multiple strategies have been applied to identify oncofetal drivers. The mechanisms of CSC resistance could also provide reliable biomarkers to predict treatment failure. Precisely targeting these specific CSC properties may be effective in preventing or annihilating therapy resistance. This review provides an overview of drug resistance mechanisms associated with CSC traits and summarize therapeutic strategies against drug resistance.
Preliminary Analysis of the Utilization of PET Plastic Waste in Tourism Areas for Energy Recovery
Authors: Septiariva Iva Yenis , Suhardono Sapta , Sari Mega Mutiara , Suryawan I Wayan Koko
Published: September 2022

Waste management at tourist sites is an unavoidable problem due to the massive number of visitors. One of the types of waste is polyethylene terephthalate (PET) plastic bottles. This study aims to analyze the potential use of PET for waste to energy in tourist areas. This research was conducted in a tourist area in Klungkung Regency, Bali Province. This study only uses grab sampling in measuring waste generation and composition. This research was conducted by proximate analysis and thermal gravimetry analysis (TGA). The measurement of waste generation shows that the PET produced is 1.24 kg/day, or about 43.5% of the total waste generation. Proximate analysis measurements show the value of moisture, ash, volatile, and fixed carbon content, which are 1.53, 0.14, 95.92, and 2.42, respectively. Meanwhile, the caloric value of PET waste is 22.71 MJ/kg. The residue from the TGA results showed 2.575%. The thermal degradation process starts at a temperature of 280ᵒC, and the initial temperature of degradation starts at 406 – and ends at 468ᵒC. Utilization of PET waste at this tourist location can also help the purpose of waste management in Klungkung Regency, namely by implementing the Waste to Energy concept at the Local Waste Processing Facility (TOSS).