bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure-activity relationship of inositol thiophosphate analogs as allosteric activators of Clostridioides difficile toxin B
Authors: Cummer Rebecca , Grosjean Félix , Bolteau Raphaël , Vasegh Seyed Ehsan , Veyron Simon , Keogh Liam , Trempe Jean-François , Castagner Bastien
Published: June 2024

Clostridioides difficile is a bacterium that causes life-threatening intestinal infections. Infection symptoms are mediated by a toxin secreted by the bacterium. Toxin pathogenesis is modulated by the intracellular molecule, inositol-hexakisphosphate (IP6). IP6 binds to a cysteine protease domain (CPD) on the toxin, inducing auto-proteolysis, which liberates a virulence factor in the cell cytosol. We developed second-generation IP6 analogs designed to induce auto-proteolysis in the gut lumen, prior to toxin uptake, circumventing pathogenesis. We synthesized a panel of thiophosphate-/sulfate-containing IP6 analogs, and characterized their toxin binding affinity, auto-proteolysis induction and cation interactions. Our top candidate was soluble in extracellular cation concentrations, unlike IP6. The IP6 analogs were more negatively charged than IP6, which improved affinity and stabilization of the CPD, enhancing toxin auto-proteolysis. Our data illustrate the optimization of IP6 with thiophosphate biomimetics which are more capable of inducing toxin auto-proteolysis than the native ligand, warranting further studies in vivo.
Chemically transferable electronic coarse graining for polythiophenes
Authors: Yu Zheng , Jackson Nicholas
Published: June 2024

Recent advances in machine-learning-based electronic coarse graining (ECG) methods have demonstrated the potential to enable electronic predictions in soft materials at mesoscopic length scales. However, previous ECG models have yet to confront the issue of chemical transferability. In this study, we develop chemically transferable ECG models for polythiophenes using graph neural networks. Our models are trained on a dataset that samples over the conformational space of random polythiophene sequences generated with 15 different monomer chemistries and three different degrees of polymerization. We systematically explore the impact of coarse-grained (CG) representation at multiple resolutions on ECG accuracy, highlighting the significance of preserving the C-beta coordinates in thiophene. We also find that integrating unique polymer sequences into training enhances model performance more efficiently than augmenting conformational sampling for sequences already in the training dataset. Moreover, our ECG models, developed initially for one property and one level of quantum chemical theory, can be efficiently transferred to related properties and higher levels of theory with minimal additional data. The chemically transferable ECG model introduced in this work will serve as a foundation model for new classes of chemically transferable ECG predictions across a broader chemical space.
A Surface-Driven Polyelectrolyte Reaction Network capable of Signal Modulation
Authors: Wong Albert , Koyuncu Aliye , Allegri Giulia , Moazzenzade Taghi , Huskens Jurriaan , Lindhoud Saskia
Published: June 2024

Biochemical communication is ubiquitous in life. The efficient means by which biology use feedback mechanisms to dynamically regulate concentrations myriad signaling molecules have inspired chemists to design chemical reaction networks (CRNs). Strategies to encode, transmit, and process information in CRNs, however, is still in its infancy. Here, we designed a microfluidic flow setup wherein a polyelectrolyte reaction network is maintained under out-of-equilibrium conditions using pH gradients. The network, comprises two weakly charged polyelectrolytes (polyallylamine, PAH, and polyacrylic acid, PAA) in solution and one immobilized on the surface (poly-L-lysine, PLL). We chose PAH and PAA as their complexation process is known to be history dependent (i.e., the preceding state of the system can determine the next state). Surprisingly, we found that the hysteresis diminished as the PLL-coated surface supported rather than perturbed the formation of the PAH-PAA complex. The role of the surface is further exploited to demonstrate that the network can enable event-driven processing. Overall, this work established that reversible switching between the assembled and disassembled state of polyelectrolytes can exploited to modulate signals encoded in the frequency and duration of pH pulses. We envision that the strategy employed to process information in this polyelectrolyte reaction network could open novel routes to modulate signals of many other biologically relevant reactions.
A Paramagnetic Nickel–Zinc Hydride Complex
Authors: Perez-Jimenez Marina , Geoghegan Blaise , Collauto Alberto , Roessler Maxie , Crimmin Mark
Published: June 2024

Reaction of a molecular zinc–hydride [{(ArNCMe)2CH}ZnH] (Ar = 2,6-di-isopropylphenyl) with 0.5 equiv. of [Ni(CO)Cp]2 led to the isolation of a nickel–zinc hydride complex containing a bridging 3-centre,2-electron Ni–H–Zn interaction. This species has been characterized in the solid-state by single crystal X-ray diffraction. DFT calculations are consistent with its formulation as a -complex derived from coordination of the zinc–hydride to a paramagnetic nickel(I) fragment. Continuous wave and pulse EPR experiments suggest that this species is not stable in solution and hint that the coordination event may well be dynamic. Further experiments show that in the presence of catalytic quantities of nickel(I) precursors, zinc–hydride bonds can undergo either H/D-exchange with D2 or dehydrocoupling to form Zn–Zn bonds. In combination, the data support the activation and functionalisation of zinc–hydride bonds at nickel(I) centres.
FRETting about CRISPR-Cas assays: Dual-channel reporting lowers detection limits and times-to-result
Authors: Lesinski Jacob , Khosla Nathan , Paganini Carolina , Verberckmoes Bo , Vermandere Heleen , deMello Andrew , Richards Daniel Ashley
Published: June 2024

CRISPR-Cas systems have evolved several mechanisms to specifically target foreign DNA. These properties have made them attractive as biosensors. The primary drawback associated with contemporary CRISPR-Cas biosensors is their weak signaling capacity, which is typically compensated for by coupling the CRISPR-Cas systems to nucleic acid amplification. This adds time and complexity to the diagnostic process, limiting the practicality of these assays for many clinical applications. An alternative strategy to improve signaling capacity is to engineer the reporter, i.e., design new signal-generating substrates for Cas proteins. Unfortunately, due to their reliance on custom synthesis or specialized analytical equipment, most of these engineered reporter substrates are inaccessible to many researchers. Herein, we present a substrate for Cas12a that functions as a seamless “drop-in” replacement for existing reporters, without the need to change any other aspect of a CRISPR-Cas12a-based assay. The reporter is readily available and employs a FRET pair to produce two signals upon cleavage by Cas12a. Use of both signals in a ratiometric manner provides for improved assay performance and a decreased time-to-result for several CRISPR-Cas12a assays. We comprehensively characterize this reporter to better understand the reasons for the improved signaling capacity and benchmark it against the current standard CRISPR-Cas reporter. Finally, to showcase the real-world utility of our reporter, we apply it to the analysis of Human papillomavirus in clinical samples
Surface modified ZnONFs with Oleic acid to fabricate nanobiosensors for uric acid detection
Authors: Dutta Priyanka , Raza Md Ramiz
Published: June 2024

In the present study, we employed an ex-situ process to modify the surface of zinc oxide nanoflowers (ZnONFs). Initially, we synthesized ZnONFs using the hydrothermal method. Subsequently, we capped the synthesized ZnONFs using the ultra-sonication method. The capped ZnONFs were then extensively characterized using various techniques, including UVvisible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and scanning and transmission electron microscopy. We then electrophoretically coated the synthesized capped ZnONFs onto bare ITO electrodes to create uric acid biosensors. The bioelectrode, UOx/Oleic acid-ZnONFs/ITO, was formed by applying EDC-NHS to the Oleic acid ZnONFs/ITO electrode and then chemically immobilizing the Uricase enzyme. We evaluated the performance of the UOx/Oleic acid-ZnONFs/ITO bioelectrode by measuring its ability to detect uric acid concentrations in a linear range from 0.005 to 1.0 mM. The bioelectrode demonstrated a low limit of detection (LOD) of 0.0044 µA/mM and an outstanding sensitivity of 685.4 µA/mM/cm². The fabricated uric acid biosensors exhibited a shelf life of over 30 days with a single interval.
Managing limited resources in emergency care: striking a balance between ethics, triage, and fairness
Authors: Shafiq Ur Rahman , Uzma Akhtar
Published: June 2024

"During my previous job, when I was working at a tertiary care hospital in Bannu, Khyber Pakhtunkhwa, once, I found myself working in the Emergency Department of a hospital that served as the only tertiary care facility for three neighboring districts. It is the only tertiary care hospital in the vicinity, especially during the current military operations against terrorists in North Waziristan. We consistently faced a high patient turnover and struggled with a severe staffing shortage due to the lack of resources and opportunities. On one occasion, we received a group of patients who had suffered multiple fractures in a road traffic accident. While I was already attending to one of these patients, the attendant of another patient approached me, insisting that their loved one's condition was equally critical due to severe pain and multiple fractures. It placed me in a challenging dilemma as both patients were in urgent need of care. I took a moment to assess the situation and continued providing care to the patient I was already attending to. My decision was based on the utilitarian principle of justice. That is a benefit for the greater maximum, in our case, I continued providing care to the same patient as that patient has a greater prognosis and needs immediate attention."
ОСОБЛИВОСТІ РОЗВИТКУ ЖИТТЄСТІЙКОСТІ ТА АДАПТИВНОСТІ ВЧИТЕЛЯ ФІЗИЧНОЇ КУЛЬТУРИ В УМОВАХ ЗМІН І КРИЗ
Authors: Варіна Г. Б. , Проценко А. А.
Published: June 2024

Наукова стаття присвячена аналізу факторів і предикторів, що впливають на процес активізації життєстійкості й адаптивності вчителя фізичної культури в умовах кризи та невизначеності. Аналіз літературних джерел інформації дав змогу визначити життєстійкість як систему переконань особистості, яка має змогу сприяти розвитку готовності особи із зацікавленістю брати участь у ситуаціях підвищеної для неї складності, тримати контроль над ними та керувати, вміти сприймати навіть негативні події як досвід і успішно справлятися з ними. Проведене дослідження дало змогу визначити чотири фактори суб’єктивно значущих психологічних загроз для вчителя фізичної культури в освітньому середовищі (суспільного характеру, інтенсивності праці, міжособистісних відносин, цифровізації освіти). Виявлено прямі взаємозв’язки задоволеності вчителя фізичної культури значущими характеристиками освітнього середовища, його референтною значимістю, психологічною захищеністю із самопочуттям і життєстійкістю; зворотні взаємозв’язки між загрозами суспільного характеру та самопочуттям педагога, життєстійкістю, психологічною безпекою та референтною значимістю. Встановлено, що основними предикторами життєстійкості вчителя фізичної культури в освітньому середовищі є його референтність і суб’єктивно значущі для вчителя загрози суспільного характеру. З огляду на виявлені предиктори життєстійкості вчителя фізичної культури, стає очевидним, що до завдань школи має входити створення більш емоційно сприятливої для вчителя освітньої екосистеми, яка заохочувала б почуття особистої цінності з боку її суб’єкта, зменшуючи тенденцію до відчуження, підтримуючи референтність середовища. Визначено, що для сприяння більш ефективному розвитку життєстійкості вчителя фізичної культури доцільно проводити навчання навичок міжособистісного спілкування, яке допоможе підготувати фахівців до участі в ефективній взаємодії зі школярами, максимізуючи почуття досягнення та зводячи до мінімуму почуття емоційного виснаження та знеособлення.
An Analysis of the Path of Digital Transformation of Knowledge in Higher Education
Authors: Huang Chen
Published: June 2024

The strategy of education digitization must be adapted to meet the challenge of the digital age and achieve the goal of education modernization. With the extensive use and deepening of information technology in the field of education, the progress of technology has made more and more obvious contributions to promoting the transformation of educational forms, expanding educational opportunities, redefining the campus environment, and optimizing learning methods. At present, global research on the digital reform of university education is still in its infancy, and more innovative thinking is needed to guide its development direction. It is foreseeable that the digital transformation of universities will revolutionize the education system, make education suitable for everyone, and make education fairer, higher quality, and more inclusive, thus improving the quality of higher education.
Discussion on the Teaching Reform of Basic Science of Traditional Chinese Medicine
Authors: Wu Lixia , Wang Jin , Quan Ruiguo , Xu Jiyan
Published: June 2024

This paper discusses the two major problems in the teaching process of the basic science of traditional Chinese medicine. One of the problems is that most of the students have learned the course of traditional Chinese medicine in previous colleges and universities, and they are familiar with the theoretical knowledge of traditional Chinese medicine. Students who follow the traditional teaching model will encounter many repetitive teaching contents, which will make the students feel unmotivated. The second problem is that the students come from different majors, different grades, and different regions, so their background and foundation of traditional Chinese medicine are uneven. According to the above problems, combined with the characteristics of students’ learning conditions, this study discusses the reform of the teaching of the basic science of Chinese medicine, including the integration of teaching materials, improving teaching methods, and putting forward some reform ideas such as hierarchical teaching guidance, which is of great significance for improving the quality of education.
Research on the Practice of the Long-Term Digital Evaluation for Chemistry Students and Field Engineer Training Path based on Intelligent Teaching
Authors: Li Caifang , Padua Shirley A.
Published: June 2024

This study takes the long-term training of chemical field engineers under the framework of digital competence in higher vocational colleges as the research object. The study combines domestic and foreign, macro and micro, qualitative and quantitative, in the investigation and problem analysis of the current situation of applied talent training in higher vocational colleges in China. Based on the successful experience of applied talent training locally and abroad, the study tries to build a talent training system with the core goal of long-term training of field engineers with the guidance of the government, colleges, and enterprises, by exploring the implementation path and reform strategy of the long-term training of field engineers.
Research on the Current Situation of Chinese Character Teaching in International Chinese Education: Based on Foreign Chinese Teaching Cases
Authors: Li Meirong
Published: June 2024

Chinese character teaching is one of the difficulties in international Chinese education. This paper analyzes the cases of international Chinese character teaching, compares the outstanding problems of each case, summarizes the common points among the cases, finds the difficulties in Chinese character teaching, and puts forward improvement measures.
Population Dynamics of the White-fronted Goose Anser albifrons (Scopoli, 1769) in the Winter Period in Western Manych in 2018–2023
Authors: Lebedeva N.
Published: June 2024

This publication is dedicated to the analysis of fluctuations in the population size of the white-fronted goose Anser albifrons (Scopoli, 1769) depending on weather and climatic conditions in winter period in Western Manych. The white-fronted goose is an Arctic species, a part of the West Siberian population of which migrates through the Kuma-Manych Depression. The study was carried out in vicinity of the Veselovsky Reservoir (Western Manych) from 2018 to 2023. Global warming led to an increase in air temperatures in the winter period in the region where the species makes migratory stopovers. Consequently, the duration of the frosty period decreased there. The average winter daily temperature (calendar winters 2018–2023) was 3 °C higher (-0.3 ± 0.1 °C) compared to the average winter temperature in the 20th century (-4.6 °C). The analysis of air temperature data made it possible to identify the alternation of “cold” and “warm” winters. The winter seasons of 2018/2019, 2020/2021 and 2022/2023 were relatively cold with negative average monthly temperatures in December – February, except for December 2022. These winters, however, were, on average, warmer than winters in the 20th century. The reservoir did not freeze completely, and the polynyas remained. The winters of 2019/2020, and 2021/2022 were warm, with positive average monthly temperatures for three months. The snow cover formed for a short time and was shallow, which facilitated geese feeding in the fields. During these winters, the population of white-fronted geese increased compared to the 1980s and 2010–2013. The maximum concentration of 30 000 individuals was recorded in December 2022. In cold winters, the number of individuals in the wintering group did not exceed 200–500 individuals. In contrast, during warm winters, between 1000 and 4000 geese stayed in the area. During most of the winter period, between 2 and 53 % of the migrants observed in early December remained at the reservoir. The study revealed that the warming climate and improved food availability in the Western Manych region in recent years resulted in the longer migratory stopovers of white-fronted geese within the area. It reduced the need for geese to travel long distances and saved them energy.
Spiders (Aranei) of Sevastopol
Authors: Prokopenko E.
Published: June 2024

The results of expeditionary studies of spider fauna in the State Nature Landscape Reserves (SNLR) Karansky, Laspi, Cape Aya and Baidarsky, located within the territory of the federal city of Sevastopol, are presented. There are no data available on spiders in these protected areas, except for three species described earlier by Yu. Semenko, M. Fedoriak and E. Zhukovets for the SNLR Cape Aya. The research material was collected in July 2023 using soil traps, entomological sweeping nets, and manual methods. The researcher surveyed areas of oak and beech forests, glades, forest edges, juniper woodlands, petrophytic steppes, meadow and wetland vegetation, stony scree, and rocky outcrops, as well as external and internal elements of buildings. Additionally, the material from the city of Inkerman provided by V.V. Martynov was analysed. In total, 70 species of spiders from 22 families were recorded as a result of the research. Twenty-eight species were found in Karansky SNLR, 29 species were identified in both Cape Aya and Laspi SNLRs, 9 species were recorded in Baidarsky SNLR, and 12 species in Inkerman. The largest number of species belonged to the families Gnaphosidae (12 species), Thomisidae (11 species), Salticidae (7 species) and Theridiidae (6 species). Eleven families were represented by a single species. The highest number of spider species was found in juniper sparse woodland. This habitat is also characterised by a high diversity of species composition — 18 species were recorded only there. Taking into account the literature data, the spider species list of Sevastopol currently includes 208 species from 33 families. The article presents an annotated list of identified spider species.
Toxic effects of drilling fluid on the embryos and prelarvae of Ruissian sturgeon Acipenser guelenstaedtii
Authors: Rudneva I. , Shaida V. , Medaynkina M.
Published: June 2024

The active development of oil and gas production on the sea shelf negatively affects aquatic organisms, leading to deterioration of their existence and reduced viability. The early stages of development of marine organisms are particularly sensitive to pollutants, which disrupt their survival rate, growth, and development. The researchers studied the impact of a drilling fluid component (an aqueous solution of hemicellulase) at concentrations of 0.1, 0.5, 1, 5, and 10 mg/L on the survival of embryos and prelarvae of the Russian sturgeon, Acipenser gueldenstaedtii (Brandt & Ratzeberg, 1833), in a saline environment (salinity 5 ‰). No differences were observed in the survival of embryos in solutions containing a toxicant at a concentration of 0.1–1 mg/l. However, when the concentration increased to 5 mg/l and higher, there was a significant (p<0.01) decrease in survival rate and delayed hatching of prelarvae. An average correlation (r=0.53) between embryo survival and substance concentration was found. The hatching of larvae in the control groups was the highest and it did not differ significantly in fresh and salty water. A concentration of 1 mg/L of the substance had no effect on fish embryos survival. Various mechanisms of the negative impact of drilling fluid on developing fish embryos are considered, including habitat deterioration, sedimentation of solid particles on the surface of eggs leading to delayed hatching, and direct toxic effects caused by the presence of toxicants, especially heavy metals, in the composition of the drilling fluid. The potential use of fish eggs to assess the ecological status of coastal marine areas in the regions of intensive oil and gas production is discussed.
Spontán lépruptúra - a repülőorvosi döntéshozatal szempontjai
Authors: Szabó Sándor András , Kuti Norbert
Published: June 2024

A spontán lépruptúra előzetes trauma vagy manifeszt vírusfertőzés által előidézett splenomegalia okozta instabilitás hiányában extrém ritka. Megítélése különösen nehéz a katonai repülőkiképzésben részt vevő pilótanövendéknél, akinél az alapbetegség vagy provokáló tényező hiánya, a lép összetett funkciója miatti terápiaválasztás okozta kompromisszum, a hirtelen cselekvőképtelenség bizonytalan kockázata és a hosszú távú munkavégző képesség (speciális harcképesség!) megőrzésének vonzata repülőorvosi szakmai, orvosetikai és katonaorvosi (alkalmassági minősítési) problémákat is felvet. A magyar légierőben előforduló eset elemzésével, saját döntéshozatali algoritmusunk kifejtésével, a rendkívül korlátozott nemzetközi szakirodalmi adatok bemutatásával egy egyedi eset bemutatásával szemléltetjük a repülőorvosi (mint speciális foglalkozás-egészségügyi) kockázatértékelés kulcskérdéseit és lehetséges buktatóit.
A csádi misszió katona-egészségügyi kihívásai
Authors: Fejes Zsolt Dezső , Mihók Sándor
Published: June 2024

Az Országgyűlés 2023. november 6-án hozzájárulását adta ahhoz, hogy a Magyar Honvédség egy – legfeljebb 200 (váltási időszakban 400) fős, a szükséges technikai eszközökkel, fegyverzettel, felszereléssel ellátott – katonai kontingense a Csádi Köztársaság területén – tanácsadási, támogatási és harctéri mentorálási feladatok ellátása, az ott tartózkodó magyar állampolgárok és a helyben lévő magyar érdekeltségek oltalmazása, továbbá a terrorizmus elleni küzdelem támogatása érdekében – 2025. december 31-ig állomásozzon és szükség szerint alkalmazásra kerüljön. Magyarország a katonai jelenlét mellett magán-, illetve állami szereplők bevonásával kíván részt vállalni Csád agráriumában, külkereskedelmében és társadalmi stabilizációjában. Cikkünkben a Magyar Honvédség Egészségügyi Központja által a magyar kontingens egészségügyi biztosítása tervezéséhez, illetve annak szervezéséhez szükséges, nyílt forrásokból származó adatokat elemezzük. Áttekintjük és a művelettervezés egészségügyi szempontjai alapján elemezzük a Csádi Köztársaság egészségügyi ellátórendszerét, valamint felhívjuk a figyelmet azokra az Európában megszokottól szinte minden dimenziójában eltérő jellemzőire, amelyek alapvetően határozzák meg az MH Egészségügyi Központ feladatait a csádi katonai misszióban.
LIKE THE STAR, LIKE THE PRODUCT? ANALYSIS OF CELEBRITY ENTREPRENEURSHIP PRODUCTS’
Authors: Mayangsari Duwi Sindi , Iqbal Daulay Muhammad  Yaser
Published: June 2024

Recently, many celebrities have started their businesses. By calling them celebrities, they become popular figures. This research seeks to offer novel perspectives and enhance comprehension regarding the correlation between celebrities functioning as entrepreneurs and the commodities they generate. The design methodology uses a questionnaire survey, this research took a sample of 321 respondents using a purposive sampling technique. The collected data was analyzed using SmartPLS software. The research findings suggest that the factors of brand love and credibility have a significant and positive influence on both brand attitude and purchase intention. Likewise, the variables of brand attitude and social media contact have a significant and favorable influence on the variable of purchase intention. The social media interaction variable does not exert any influence on the brand attitude variable, distinguishing it from this variable. Furthermore, the mediating variables demonstrate that both brand love and credibility variables have a significant and positive influence on the purchase intention variable through the brand attitude variable. However, the social media interaction variable does not have any influence on the purchase intention variable through the brand attitude variable. This research is different from previous research. Researchers explore and add to the independent variables studied. In previous research, we only examined the credibility variable, whereas in this research the researchers used 3 independent variables, namely love of the brand, credibility, and social media interaction.
MODEL OF TOURIST SATISFACTION IN VISITING MANGROVE TOURISM OBJECTS
Authors: Nur Inayah Hanum Salsabila , Isa Muzakar
Published: June 2024

This study aims to analyze the effect of tourist attraction, accessibility, facilities, and environment on tourist satisfaction at the Kertomulyo Beach Mangrove Tourism Object in Pati Regency. This study uses a quantitative approach with a questionnaire as data collection material. The sample taken was 339 tourist respondents who visited the Kertomulyo Beach mangrove tourist attraction. Sampling technique using Non- non-probability Sampling with Purposive Sampling method. The results of this study indicate that partially the variables of tourist attraction, accessibility, facilities, and environment have a positive and significant effect on tourist satisfaction at the Kertomulyo Beach mangrove tourist attraction in Pati Regency.
EXAMINING THE ROLE OF SOCIAL MEDIA INTERACTIONS AND PARA-SOCIAL INTERACTION ON CELEBRITY PURCHASE INTENTION
Authors: Damayanti Saskia , Iqbal Daulay Muhammad Yasser
Published: June 2024

Presently, social media exerts a profound influence on creating customer impressions of both celebrities and product companies. Moreover, the existence of emotional connections with celebrities often has a significant impact on consumers' intentions to buy. This study examines the relationship between social media interactions, para-social interactions, and celebrity attachment, and how these influence purchase intentions through brand attractiveness as a mediator. A total of 254 participants were selected for this study using the purposive sample strategy, and questionnaires were distributed to collect data. The data analysis technique uses Smart PLS with validity and reliability test analysis and t-test. The research findings indicate that brand attractiveness, celebrity attachment, and para-social interaction have a substantial and favorable impact on the purchase intention variable. Similarly, the factors of celebrity attachment and para-social contact exert a substantial positive impact on the variable of brand appeal. The social media interaction variable, in contrast, does not exert any influence on the variables of brand attractiveness and purchase intention. Furthermore, the mediating variables demonstrate that both para-social interaction and celebrity attachment variables have a substantial and favorable influence on the purchase intention variable via the brand attractiveness variable. Nevertheless, the variable of social media involvement does not exert any influence on the variable of purchase intention through the variable of brand attractiveness. This research is slightly different from previous research which examined brand credibility. Researchers explore and transform variables into brand attractiveness. Researchers also found that celebrity-endorsed purchase intentions increase brand appeal. In previous research two variables acted as mediation, namely para-social interaction and brand attractiveness, whereas in this study the mediating variable used was only brand attractiveness, para-social interaction acted as an independent variable.
HUMAN RESOURCES IN THE DIGITAL TRANSFORMATION ERA : A LITERATURE REVIEW STUDY
Authors: Rustanti Dika , Lestari Kartawijaya Merry Ayu , Iqbaal Maulana Muhammad , Yuniawan Ahyar
Published: June 2024

This research aims to explain the challenges faced by human resources in the digital transformation era and what strategies can be used to face these challenges. The research method in this study utilized a systematic literature review. Data from this research was obtained through several international journal articles with the keywords human resources in the digital transformation era. Data analysis in this research utilized qualitative data analysis. The research results show several challenges faced by human resources in the digital transformation era, including technology-induced unemployment, platform work, work polarization, and non-standard work. Apart from that, some strategies can be utilized to overcome these various challenges, including talent selection, training and development, evaluative functions, and digital employee services.
DETERMINATION OF THERMAL ENERGY AND WASTES GENERATION RESULTING FROM INCINERATION OF ONE TON OF CRUDE OIL CONTAMINATED SOILS OF QURNA OIL FIELDS IN BASRA, IRAQ
Authors: Hadi Ahmed H. , Ahmed Ahmed Hatif , Hussain Basim A. , Abd AL Razak Abdullah F.
Published: June 2024

A theoretical study is presented to calculate the thermal energy and wastes generated from complete combustion of (1 ton/h) of Qurna crude oil contaminated soil in Basra city south of Iraq. Practical values which are valid in the literature are taken for the constituents of the soil and the crude oil. A multi chamber incinerator with capacity of (1 ton/h) is designed to incinerate the crude oil contaminated soils using diesel fuel to reach to (1200˚C) burning temperature. The resulted thermal energy was found to be (5.59 MW) which is sufficient to evaporate (9918.449 liter/h) of industrial wasted water using many of Shore VAP water evaporators systems. The resulting hazardous flue gases and wastes obtained were (CO2=1773.46 kg/h, SO2 = 13.58kg/h, H2SO4 =0.643125kg/h (350 ml/h)) using excess air ratios of 150% for solid wastes burning and 20% for diesel fuel burning.
EXAMINING THE MULTIFACETED GENIUS: KISHORE KUMAR'S ENDURING INFLUENCE ON INDIAN CINEMA
Authors: Rohit
Published: June 2024

Kishore Kumar's captivating voice and multifaceted artistry transcended generations, leaving an enduring impact on Indian cinema and society. This mixed-methods study delves into his multifaceted impact. Through surveys, expert interviews, and critical analysis, the research reveals how Kishore Kumar revolutionized playback singing with his unique vocal range, emotional delivery, and innovative techniques like yodeling. His significant contributions to acting and filmmaking are also examined. The study further explores his lasting influence on contemporary artists (76.9% acknowledging his inspiration) and a significant portion of the audience (84.6%) who believe his music resonates across generations, shaping social and cultural identity. By understanding Kishore Kumar's multifaceted impact, we gain a deeper appreciation for his artistry and its enduring legacy on the evolution of Indian cinema and the cultural fabric of Indian society.
Muscle Tissue Use Prospects of Freshwater Fish of the Amur Region to Develop Innovative Food Products
Authors: Derzhapolskaja Yuliya I. , Reshetnik Ekaterina I. , Gribanova Svetlana L. , Pashina Lubov L. , Pakusina Antonina P.
Published: June 2024

The muscle tissues of freshwater fish are a valuable source of protein, essential fatty acids, vitamins and minerals. In recent years, a man has actively explored the possibility of using these fabrics to develop innovative food products meeting the needs of modern consumers. The research aimed at studying the biological potential of the muscle tissue of Amur catfish Parasilurus asotus and Amur pike Esox reichertii. The object was frozen fish. The authors determined the nutritional value of freshwater fish of the Amur region water basin: the protein content in the muscle tissue of Amur catfish is 17.2 g/100 g, Amur pike is 18.4 g (22.6 and 24.2% of the daily protein requirement, respectively). The researchers specified amino acid protein composition of the muscle tissue of freshwater fish of the Amur region water basin and the amino acid score. They demonstrated that this muscle tissue contained an insufficient amount or an incorrect ratio of amino acids necessary to maintain health and normal functioning of the body. A man revealed the biological value of the lipid component and the fatty acid composition balance of the muscle tissue of the studied freshwater fish species of the Amur region water basin. The fatty acid composition analysis of lipids showed the prevalence of polyunsaturated fatty acids in them. Its content exceeded the value of the “ideal lipid” for the muscle tissue of catfish by 2 times and pike by 2.5 times.
Ciborgue das Trincheiras
Authors: Thomaz Giullia , Curzi Yasmin
Published: June 2024

O ensaio propõe discutir a mediação técnica por meio de dispositivos móveis, em particular celulares, e seu impacto na comunicação de jovens militares dentro das trincheiras da guerra na Ucrânia. Tal mediação por smartphones e novas mídias formam um contexto ímpar para pensar a auto exposição a partir de um cenário de vigilância já distópico, porém agravado pelas condições de sobrevivência. Explora-se a oposição humano/tecnológico, incluindo críticas à objetividade científica e, assim, introduz o conceito de ciborgue conforme Haraway (2016). Destaca-se a contribuição crítica Haraway aos imaginários sociotécnicos que buscam se opor às dicotomias e binarismos que predominam na epistemologia ocidental. O ensaio propõe uma nova ontologia humana que abarque as contradições próprias do ser humano, em contraposição aos purismos do renascimento cristão e demais promessas da civilização moderna.
Understanding the factors that influence visitor perceptions regarding wildlife tourism with Amazon River dolphins
Authors: Vidal Marcelo Derzi , Santos Priscila Maria da Costa , Chaves Maria do Perpétuo Socorro Rodrigues , Moreira Jasmine Cardozo , Burns Robert Clyde
Published: June 2024

Understanding the factors that influence the visitor’s perceptions regarding wildlife tourism is essential to management of its potential negative impacts. This article presents the profile, and visitor perception, regarding tourism with Amazon River dolphins in the Anavilhanas National Park, Brazil. Using a semi-structured script, interviews were carried out with 175 visitors of the “Flutuante dos Botos”, enterprise where the interactions with cetaceans occur. The interviewees hailed from 12 countries from North and South America and Europe. Most interviewees reported an age within a range from 18-27 years, a higher education degree and a high monthly household income. The main feeling aroused by the interactions with dolphins was that of happiness/excitement yet many visitors have expressed dissatisfaction with the enterprise staff. Although the model of how the activity is carried out, based on food supply, harms the cetaceans’ natural behaviour based on hunting, most interviewees believe that tourism helps to preserve the species by promoting people's awareness and making people acquire important knowledge. Our results provide important information for managers of the enterprise and the Protected Area, so they can better understand tourism and develop adequate management strategies for interactions between the tourist and the Amazon River dolphin.
Feasibility of Web-based Digital Arabic Gamification Media for Islamic Junior High School Students
Authors: Shiddiq Jamaluddin , Zubaidi Ahmad , Nur Kholis Muhammad , Rokhani Rokhani
Published: June 2024

This research aimed to determine the feasibility of web-based digital Arabic language gamification media from experts and users. Specifically, the research investigated the feasibility analysis of web media with the URL: https://belajararabonline14.wordpress.com/ containing Plotagon, Wordwalls, and Genially apps in learning Arabic at the Junior High School level. Generally, Arabic language instruction remains conventional and lacks interactivity. Consequently, students may experience boredom and reduced motivation to learn. Creating interactive materials using gaming principles could be one approach to solving this issue. This research was a type of quantitative descriptive research. This research involved 37 users and 4 validators. Data collection was carried out by distributing questionnaires to validators and users of this media and was analysed using descriptive statistics. The findings showed that web-based digital Arabic language gamification media received very valid responses from experts and users with details: a score of 4.53 from material experts, a score of 4.41 from media experts, a score of 4.93 from teacher responses, and a score of 4.06 from students. These findings suggest to Arabic teachers the potential benefit of incorporating this media as an auxiliary resource in Junior High School-level Arabic language instruction.
Code-Mixing of Language in Student's Daily Conversations at Islamic boarding school
Authors: Kirom Abdul , Ainin Moh , Wijaya Mualim , Hasanah Uswatun , Qibtiyah Luthfatul
Published: June 2024

This research aimed to describe the types of linguistic interference in the conversations of students at the Al-Amien Islamic boarding school Prenduan of Sumenep Madura, and to describe the linguistic methods for correcting errors in their linguistic interference. In this study, the researchers used a descriptive qualitative approach. The study relied on interviewing some professors at the institute, observation, and documentation of all data. The researchers arrived at several results, including: The types of linguistic overlap that occurred during students’ conversations in Arabic at the Al-Amien Islamic Boarding School Prenduan of Sumenep Madura were represented by morphological overlap from the Madurese language to the Arabic language, morphological overlap from the Indonesian language to the Arabic language, semantic overlap from the Madurese language to the Arabic language, and semantic overlap from the Indonesian language to the Arabic language. Al-Amien Islamic Boarding School Prenduan of Sumenep Madura employed methods for teaching the Arabic language through daily conversation expressions to rectify linguistic overlaps among students. This approach was documented in booklets authored by KH. Mohammad Marzuki Ma’ruf, who held the primary responsibility for Arabic language instruction. The booklets included: A book on correcting errors in the Language Week Arabic, a book of terminology and error correction, a book of common terms, a book of daily conversation, and a book of daily terms and methods. From these mentioned books, materials for the error correction program for linguistic interference were extracted, and activities were conducted throughout the Al-Amien Islamic Boarding School, encompassing both formal and informal activities spanning twenty-four hours.
Integration of Maqashid Syaria in Nurcholish Madjid’s Thingking about Principles for Effective Good Governance
Authors: Syamsuar Syamsuar , Chapakia Ahmad Omar , Hamsa Amrizal , Amelia Amelia
Published: June 2024

This research aims to integrate the concept of Maqasid Syaria with Nurcholish Madjid's framework of good governance. There exists a conceptual gap that requires deeper understanding, as Nurcholish Madjid's theories on good governance may hold perspectives, goals, or assumptions that differ from the principles of maqasid syaria. The study employed the content analysis method, a systematic approach to examining the fundamental aspects of the material under investigation, specifically literature on good governance and maqashid syaria, as initiated by Nurcholish Madjid. The study's findings reveal three main points. Firstly, Nurcholish Madjid emerges as a highly influential contemporary figure within Islam, particularly in Indonesia during the 20th-century transition period. His ideas underscore the necessity of renewing Islam in line with societal demands and contemporary knowledge. His philosophy emphasizes the elevation of human dignity, equality, religious freedom, and social maturity when confronting diversity. Secondly, the compatibility between the maqashid syaria and Nurcholish Madjid's ideologies stems from their shared sources—the Qur'an and Hadith. This relationship is further bolstered by the Qawa'id fiqhiyyah approach, which establishes principles of effective governance. Lastly, Nurcholish Madjid's principle of good governance is grounded in the principle of tawhid and resonates with the maqashid syaria (syaria objectives) framework, particularly concerning muhafadah al-din. Notably, the tawhid principle, concerning the types of maqashid syaria al-Syatibi, falls within the daruriyyah (fundamental) category. Conversely, the hajiyyah level comprises the supportive principles.
Unlocking The Puzzle: Locus of Control, Fintech and Financial Literacy in Shaping Financial Behavior
Authors: Kiswanti Hanny Mahasih , Khouroh Umu , Yuniarti Sari , Herdiyanti Indyah
Published: June 2024

This study is intended to analyze the financial management behavior of merchants in Pasar Besar, Malang City in terms of locus of control and fintech perspectives by presenting financial literacy as a mediation variable. The research design used is quantitative with explanatory research methods. The study population is merchants in Pasar Besar, Malang City with probability sampling techniques using the simple random sampling method. Data analysis techniques using partial least square-structural equation model (PLS-SEM). The results showed that locus of control and fintech have a significant positive effect on financial management behavior; Locus of control and fintech have a significant positive effect on financial literacy. The results also stated that financial literacy can mediate the influence of locus of control and fintech on financial management behavior.
The role of the AKT1 gene in the pathogenesis of type 2 diabetes mellitus and its complications
Authors: Kochetova O.V. , Shangareeva Z.A. , Avzaletdinova D.Sh. , Viktorova T.V. , Korytina G.F.
Published: June 2024

Introduction. Type 2 diabetes (T2D) is a chronic metabolic disorder. The number of diabetic people is increasing. AKT1 is a protein kinase and a participant in the PI3K/AKT/mTOR signaling pathway. The aim of the study was to analyze the association of polymorphic variants rs3803300 and rs2494732 of the AKT1 gene with the risk of developing type 2 diabetes and its complications. Methods. PCR-RFLP analysis was used to study polymorphic variants of two polymorphic loci of the AKT1 gene. DNA samples of 533 patients with T2D and 397 individuals of the control group were used in the work. Results. The association of the rs3803300 locus of the AKT1 gene with the risk of developing T2D, the effect allele T (р=0.02), and the risk genotypes of CT-CC of the rs2494732 locus of the AKT1 gene (р=0.042) were revealed. It was shown that carriers of the CT-CC genotypes of the rs2494732 locus of the AKT1 gene had an increased weight (р=0.026). An association of the rs3803300 locus of the AKT1 gene with the risk of developing diabetic retinopathy (р=0.021), polyneuropathy (р=0.0084), coronary heart disease (р=0.032) and diabetic encephalopathy (р=0.0064) was found. The rs2494732 locus of the AKT1 gene is associated with the development of diabetic nephropathy (р=0.024). Conclusion. The data obtained indicate the prospects of analyzing the PI3K/AKT/mTOR signaling pathway genes for the search for personalized predictors of T2D and its complications.
Occupational burnout in physicians after the COVID-19 pandemic
Authors: Khabibulina M. , Bazhenova O. , Shamilov M.
Published: June 2024

The COVID-19 pandemic has caused crises in almost all areas – healthcare, politics, economics, education, etc. Doctors who faced increased workload and higher stress in the workplace were at maximum risk of developing professional burnout. Purpose. To analyze the indicators of professional burnout syndrome among doctors of COVID hospitals, outpatient clinics and multidisciplinary hospitals 3 years after the COVID-19 pandemic. Materials and methods. 3 groups of doctors were included in the study: those who worked in COVID hospitals (n=103); outpatient doctors (n=108) and doctors of multidisciplinary hospitals (n=107), as well as the control group (n=109). A survey was conducted in all groups. To study the syndrome of professional burnout, the questionnaire Maslach Burnout was used. Results. Professional burnout rates were increased in all groups of doctors. COVID hospital doctors have significantly higher rates of “professional exhaustion” and “depersonalization" compared to doctors of multidisciplinary hospitals (p≤0.001) and outpatient doctors (p≤0.001) and a lower rate of "reduction of personal achievements". Risk factors that have the maximum impact on the psychological health of doctors during the COVID-19 pandemic: the risk of infection, social isolation, changes in the organization of working conditions. Conclusion. All groups of doctors demonstrate increased values in the direction of “professional burnout”. Thus, COVID hospital doctors have significantly higher rates of “professional exhaustion”, “depersonalization” and low rates of "reduction of personal achievements", compared with colleagues from multidisciplinary hospitals and outpatient clinics, even after 3 years. Treatment of patients with COVID-19 exposes health workers to specific risk factors: regular contacts with infected patients, significant changes in the organization of work and social distancing, which contributes to an increase in stress and emotional burnout.