bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression Analysis and Nuclear Import Study of Full-length Isoforms Importin α as 6x Histidin-tagged Fusion Protein on the Intracellular Localization of Recombinant HBV Core Protein
Authors: Haryanto Aris
Published: April 2018

Isoform importin α molecules play a central role in the classical nuclear import pathway, that occurs throughthe nuclear pore complex (NPC) and typically requires a specific nuclear localization signal (NLS). In this study,it was investigated the role of isoforms importin α in the nuclear import of wild type recombinant hepatitis B viruscore protein (WT rHBc), phosphorylated recombinant HBV core (rHBc) and recombinant HBV core without NLSby co-immunoprecipitation. Four recombinant full-length isoforms importin α as 6x histidin-tagged fusion proteinwere expressed and analysed from expression plasmid vectors Rch1, pHM 1969, pHM 1967 and pHM 1965. Theresults indicated that importin α-1, importin α-3, importin α-4 and importin α-5 can be expressed and isolatedfrom E. coli transformed recombinant DNA plasmid as protein in size around 58-60 kDa. By the nuclear transportstudy shown that isoforms importin α are involved in the nuclear import of WT rHBc, phosphorylated rHBc andrHBc without NLS. It also indicated that they have an important role for nuclear transport of from cytoplasm intothe nucleus.Keywords: NPC, NLS, importin α, importin β, isoforms importin α as 6x histidin-tagged fusion protein, WTrHBc, SV40 Tag, co-immunoprecipitation, westernblotting.
Production of Poly-α-hydroxybutyrate (PHB) from Sago Starch by The Native Isolate Bacillus megaterium PSA10
Authors: Yanti Nur Arfa , Sembiring Langkah , Margino Sebastian
Published: April 2018

A new bacterial strain that produces amylase and poly-α-hidroxybutyrate (PHB) using sago starch as carbon source was characterized and identified to be member of the Bacillus megaterium group based on phenotypic characteristics and 16S rDNA gene sequences. Amylase activity was determined spectrophotometrically on the basis of substrate concentration reduction. PHB production was quantified with UV spectrophotometer. The polymer produced by B. megaterium PSA10 was identified by Fourier Transform Infrared spectroscopy (FTIR). The result of the study showed that the amylase specific activity B. megaterium PSA10 was 593,61 DUN/mg protein and PHB production from sago starch was 52,28 % of cell dry weight (CDW). FTIR analysis of the polymer indicated that the strain B.megaterium PSA10 was a potent PHB producer.
Effect of Probiotic Lactobacillus sp. Dad13 on Humoral Immune Response of Balb/C Mice Infected with Salmonella typhimurium
Authors: Kusumawati Ika Dyah , Harmayani Eni , Asmara Widya
Published: April 2018

An indigenous strain of lactic acid bacterium (LAB) identified as Lactobacillus spp. Dad13 (Dad13), isolatedfrom traditional fermented buffalo milk, was found to be potential as probiotic. The aim of this research was to studythe effect of probiotic Dad13 on humoral immune response of Balb/C mice infected with Salmonella typhimurium. Thespecific objective was to find out the effect of different Dad13 consumption time (before and along with infection of S.typhimurium) on the humoral immune response of Balb/C mice. The experiment was conducted by in vivo trial on 20males of Balb/C mice, age of 6-8 weeks, fed with AIN-93 standard diet. The mice were assigned into 4 groups. Eachgroup received the following treatments, ie. Dad13 only, Dad13 before infection, Dad13 along with infection andSalmonella infection only. A volume of 100 μl Dad13 cell suspensions (1010 CFU/ml) were given by oral forced feedingdaily for a week, at week 3 for group before infection and at week 4 for group of Dad13 only and Dad13 along withinfection. Salmonella infection (109 CFU/ml) was given once orally at week 4 to all groups except group treated withDad13 only. The humoral immune response of Balb/C mice was detected 2 weeks after infection by measuring thetiters of IgG and IgA specific from serum and mucosal intestinal liquid samples using Enzyme-linked ImmunosorbentAssay (ELISA) method. The result indicated that humoral immune response of Balb/C mice consuming Dad13 beforeand along with Salmonella infection were significantly different (p<0.05). Dad13 consumption along with Salmonellainfection increased circulated IgG and IgA as well as secretory IgA. It can be concluded that Dad13 probiotic feedingalong with infection increased humoral immune response more significantly compared to that before infection.Key words : Probiotic, Lactobacillus sp. Dad13, Immune response, Salmonella typhimurium
In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives
Authors: Mustofa M. , Mallié Michèle , Valentin Alexis , Lewin Guy
Published: April 2018

An indole alkaloid with aspidospemane structure possessing a potential antiplasmodial activity,vincadifformine, has been isolated from Aspidosperma pyrifolium Mart. Moreover, 10 derivatives were preparedfrom the vincadifformine. The study was conducted to evaluate the in vitro antiplasmodial and cytotoxic activity ofthe vincadifformine and their semisynthetic derivatives. The in vitro antiplasmodial activity was evaluated onPlasmodium falciparum chloroquine-resistant (FcM ) and –sensitive (Nigerian) strains after 24-h and 72-h incubation, 29while cytotoxic activity was estimated on Hela cells and Cytotoxicity Index (CI = IC on HeLa cells/IC on FcM strain) 50 50 29was calculated to evaluate the safety of tested compounds. Experiment results showed that two compounds (4 and 8)exhibited good antiplasmodial activities in comparison with parent compound, vincadifformine and other testedcompounds with IC ranging from 5.3 to 12.8 μM on FcM strain and 11.4 to 24.0 μM on Nigerian strain. In addition, 50 29the CI of two compounds were also lower after 24-h incubation (CI, 2.0 and 4.8) than that of after 72-h incubation (CI,9.5 and 11.5). Further study will be conducted to evaluate quantitative structure-activity relationship (QSAR) in orderto design new antimalarial drugs.Keywords : vincadifformine - antiplasmodial – Plasmodium falciparum – cytotoxic - HeLa
Apoptosis and Phagocytosis Activity of Macrophages Infected by Mycobacterium tuberculosis Resistant and Sensitive Isoniazid Clinical Isolates
Authors: Rachmawaty Farida J. , Wibawa Tri , Soesatyo Marsetyawan H.N.E.
Published: April 2018

Mycobacterium tuberculosis (M.tb) is the main causative pathogen that cause the pulmonary tuberculosis.Intracellular M.tb was reported able to induce macrophages apoptosis, which may have crucial role in the regulationof immun response against M.tb infection. As an intracellular bacteria, M.tb able to live and replicate withinmacrophages. Phagocytosis is the first step to achieved this condition. The induction of macrophages apoptosis byINH resistant and sensitive M.tb clinical isolates, and H37Rv was studied. The macrophages apoptosis level weremeasured using an Ag-capture ELISA for histone and fragmented DNA (Cell Death Detection ELISAplus, RocheDiagnostic GmBH). Phagocytosis activity also analyzed, after staining using fluorescence dye (AcriFluorTM, ScientificDevice Lab.). The results showed that there was no significantly different between INH resistant and sensitive M.tbclinical isolates in respect their ability to induce apoptosis. The phagocytosis activity among the clinical isolates wasshown to be strain dependent, and undistinguishable between the Mtb clinical isolates. There was no associationbetween macrophages apoptosis level and the phagocytosis activity. These data suggested that among the virulentMtb clinical isolates, the ability to induce macrophages apoptosis and phagocytosis were consistently in comparablelevelKeywords: Mycobacterium tuberculosis, apoptosis, phagocytosis, macrophages, isoniazid
Effect of Culture Medium Supplementation with b-mercaptoethanol and Amino Acid on Canine Intergeneric Embryo Development with Porcine Oocyte Cytoplasm Recipient
Authors: Fibrianto Yuda Heru
Published: April 2018

The present study investigated the effect of culture medium supplementation with mercaptoethanol ( ME)and amino acid (AA) on canine intergeneric embryo development with porcine oocyte cytoplasm. Porcine cumulusoocyte complexes (COCs) were collected from slaughterhouse and matured in TCM-199 supplemented with 26.2mM NaHCO, 3.05 mM glucose, 0.91 mM sodium pyruvate, 0.57 mM L-cysteine, 75 mg/l kanamycin, 10 ng/ml 3epidermal growth factor, equine chorionic gonadotropin (eCG), 10 IU/ml human chorionic gonadotropin (hCG),and 10% (v/v) porcine follicular fluid (pFF) at 39 °C in a humidified atmosphere of 5% CO for 42-44 h and donor cell 2collected from ear skin afghanhound male dog. After somatic cell nuclear transfer (SCNT), embryo developmentwere examined for cleavage rate and 144 hr for final development after cultured in media. The result shows that,amino acid and mercapoethanol addition in culture medium (NCSU-23) have no effect on embryo development.The development rate of embryo until 16 cell stage in NCSU and NCSU supplement are 4.67% and morula stage are3.73% and 4.67%.Key words : intergeneric clone embryo, canine, ( amino acid (AA)
Field Report: Implementing a Social Science Capability in a Marine Corps Organization
Authors: Fosher Kerry B.
Published: April 2018

In 2010 the Marine Corps started a small, experimental capability, the Translational Research Group (TRG), to help the organization more effectively integrate social science and scientists into decision-making. In contrast to other recent military social science programs, TRG focuses inward, on Marines and Marine Corps organizations. The group houses fieldwork-focused social scientists within a military organization so they can understand the problem-framing context and implementation processes, but provides significantly greater academic freedom and protection from over-tasking than is the norm in military research settings. Researchers conduct independently designed projects, support curriculum development, and provide social science advice to a broad scope of military organizations. Although leadership support for the group has been strong, there have been significant impediments to fully institutionalizing the capability. This field report provides an outline of the background and design of the group and examines some of the key challenges encountered during implementation.
Prevalencia de enfermedades crónicas no transmisibles, Trinidad-Casanare, 2012-2014
Authors: Castañeda Porras Oneida , Segura Omar , Parra Rodríguez Aida Yadira
Published: April 2018

Objetivo. Establecer la prevalencia de las enfermedades crónicas no transmisibles (ECNT) en el municipio de Trinidad-Casanare durante 2012-2014.Métodos. Estudio descriptivo, transversal, retrospectivo a partir de datos consignados en los Registros Individuales de Prestación de Servicios (RIPS). Análisis realizado mediante estadística descriptiva con Epi-Info 7.2.0.Resultados. El 11,6%(1.032/8.934) de registros fueron ECNT, en 2012(317; 30,7%), 2013(299; 29,0%) y 2014(416 (40,3%); área urbana 757(73,3%), rural 230(22,2%), sin datos 45(4,3%); hombres 466(45,2%) y mujeres 566(54,8%); edad promedio 40 ±25,8(rango=0,2-106); razón hombre/mujer 4:5. Prevalencia por sistema: respiratorio 301(29,1%), digestivo 253(24,5%), circulatorio 186(18,0%), endocrino 57(5,5%), genitourinario 155(15,0%), trastornos mentales/orgánicos 29(2,8%), osteomuscular/tejido conectivo 20(1,9%); hematológico/anemia 11(1,1%), nervioso 10(1,0%), oncológico/neoplasias 6(0,6%), genético 4(0,4%).Conclusiones. Se evidencia un incremento en el número de personas atendidas durante el período a estudio con predominio del sexo femenino. Se recomienda la vigilancia de estas condiciones en aras de definir prioridades a mediano y largo plazo para la Salud Pública local.
An efficient synthesis of novel triazoles incorporating barbituric motifs via [3+2] cycloaddition reaction: An experimental and theoretical study
Authors: Darroudi Mahdieh , Sarrafi Yaghoub , Hamzehloueian Mahshid
Published: April 2018

In this work, the synthesis of novel triazole derivatives with barbituric motifs in good yields is described. The alkyne was prepared through the Knoevenagel reaction of barbituric derivatives with ortho and para O-propargylated hydroxybenzaldehyde. The mechanism and regioselectivity of this [3+2] cycloaddition reaction were investigated using the density functional theory at the B3LYP/6-31+G(d) level of theory. The computational studies revealed that a di-copper catalyzed stepwise mechanism, involving six-membered ring intermediate, is the preferred pathway. The regioselectivity was explained in terms of frontier molecular orbital (FMO) interactions, local and global electrophilicity and nucleophilicity indices. Accordingly, the favored interactions for di-copper acetylide are in good agreement with the observed regioselectivity, while completely opposite results were obtained for a possible uncatalysed reaction.
Prediction of mandibular movement and its center of rotation for nonsurgical correction of anterior open bite via maxillary molar intrusion
Authors: Kim Kyunam , Choy Kwangchul , Park Young-Chel , Han Seo Yeon , Jung Heekyu , Choi Yoon Jeong
Published: April 2018

Objectives:

To evaluate quantitatively the relationship between molar intrusion (change [Δ] maxillary first molar [U6]–palatal plane [PP]) and changes in vertical and sagittal cephalometric parameters and to determine the center of mandibular autorotation.

Materials and Methods:

Twenty-one patients diagnosed with anterior open bite and successfully treated with molar intrusion (overbite [OB] > 0 mm) were retrospectively enrolled. Lateral cephalograms taken before and after molar intrusion were used to measure changes in vertical and sagittal cephalometric parameters. The center of mandibular autorotation was calculated by measuring displacement of gonion (Go) and pogonion (Pog). Paired t-tests were used to compare variables, and linear regression analysis was used to examine the relationship between ΔU6-PP and other variables.

Results:

The mandible exhibited counterclockwise rotation after maxillary molar intrusion, which led to closure of anterior open bite. Strong linear relationships, in descending order, between ΔU6-PP and ΔOB, Δanterior facial height (AFH), Δvertical reference plane (Pog), and Δsella-nasion to Go-menton (SN-GoMe), were observed. When the maxillary molar was intruded 1 mm, OB increased by 2.6 mm, AFH decreased by 1.7 mm, Pog moved forward by 2.3 mm, and SN-GoMe decreased by 2°. The center of mandibular autorotation was located 7.4 mm behind and 16.9 mm below condylion after molar intrusion.

Conclusions:

The mandible exhibited counterclockwise rotation after maxillary molar intrusion; the center of mandibular autorotation was located behind and below condylion with individual variations.
PELATIHAN KOMPETENSI LINTAS BUDAYA DAN KETAHANAN BAGI PASUKAN PENJAGA PERDAMAIAN PBB: SEBUAH USULAN
Authors: Indrawan Raden Mas Jerry
Published: April 2018

Does culture pose significant threat to UN Peacekeeping Forces in their line of duty in conflict areas? Does it affect their role as peacekeepers in midst of conflicts? Peacekeeping is not an ordinary military assignment, like in war. Peacekeeping Operation requires certain skills, such as cross-culture competence and high cultural resilience. Hence, peacekeeping work must be understand as an activity that rely more on cooperation, integration from all related stakeholders, and coordination between UN Peacekeeping Mission with other parties, like civilians, government, police, humanitarian workers, mass media, etc. nowadays, the complexity of UN missions requires variation in their training methods. This paper will discuss several of training programs involving the entire component of peacekeeping forces, including their family, regarding to cross-cultural competence and cultural resilience.
Lingua e Sociedade en Galicia
Authors: Monteagudo Henrique
Published: April 2018

O artigo ofrece unha ampla revisión da situación social da lingua galega, comezando cunha breve historia do seu contacto co castelán e centrada especialmente nos cambios sociolingüísticos das últimas décadas, despois da súa oficialización como “lingua propia” da Comunidade Autónoma de Galicia. O traballo presenta e analiza datos estatísticos sobre as variables sociolingüísticas e sociais máis relevantes (lingua inicial, competencia lingüística, lingua habitual), presenta unha síntese do proceso de estandarización e comentarios sobre as controversias normativas e os seus efectos sociais, a diversidade de prácticas e as representacións que xurdiron como consecuencia do contacto co castelán neste complexo escenario de intervencións políticas sobre o status e corpus da lingua galega.
Situando o galego no terreo da investigación lingüística: os traballos de fonética e fonoloxía
Authors: Fernández Rei Elisa , Regueira Xosé Luís
Published: April 2018

Neste artigo preséntase unha visión panorámica dos estudos de fonética e fonoloxía galegas. Se aínda nos anos 1960 a fonética galega era practicamente descoñecida, os avances experimentados desde entón pretenden situar os estudos destas especialidades no ámbito da investigación lingüística internacional. Debido ás prioridades que ocuparon a axenda da investigación durante as décadas de 1970 e 1980, relacionadas fundamentalmente coa planificación do corpus e coa estandarización, os traballos sobre fonética galega non empezan a desenvolverse ata os anos 1990, e fano fundamentalmente no seo do Instituto da Lingua Galega. Desde entón levouse a cabo un certo número de traballos de corte experimental, tanto no estudo da fonética segmental coma na suprasegmental (fundamentalmente, a entoación). Non obstante, os recursos limitados que se dedican a esta rama da lingüística galega fai que aínda existan importantes lagoas. No tocante á fonoloxía, dentro de Galicia domina a perspectiva estruturalista, marcada pola obra de Amable Veiga. Mais desde os anos 1990 un importante número de traballos realizados desde a teoría xenerativa e dentro do marco teórico da optimidade, levados a cabo sobre todo en universidades norteamericanas, abordou a interpretación dalgúns dos aspectos máis elusivos da fonoloxía galega, que presentan implicacións teóricas de relevancia. A pesar das limitacións mencionadas, na actualidade están a desenvolverse traballos en liñas e marcos teóricos innovadores, que abren interesantes camiños para o estudo de aspectos aínda pouco tratados, como son a variación entre falantes e entre variedades ou o contacto co español, coa incorporación de perspectivas innovadoras, como o estudo da percepción relacionado coa produción.
Panorama actual da lingüística histórica galega
Authors: Varela Barreiro Xavier , Pichel Ricardo
Published: April 2018

Os estudos de lingüística histórica galega gozan de boa saúde na actualidade e é numeroso o grupo de investigadores que, desde lugares e países moi distantes entre si, participan no seu desenvolvemento. Neste artigo os autores ofrecen unha breve panorámica das achegas recentes a esta disciplina filolóxica, focando o obxectivo principalmente na produción bibliográfica, nos recursos de investigación accesibles na Internet, nos proxectos de investigación en andamento e nos encontros e eventos científicos centrados nesta área da lingüística galega.
Fitazlar: Çevreye Etkisi, Beslenme ve Biyoteknolojideki Önemi
Authors: BERİKTEN Derya , KIVANÇ Merih
Published: April 2018

Hayvanlar

alemi için önemli besin kaynaklarından olan tahıllarda, baklagillerde ve yağlı

tohumlarda fosfatın temel depo formu fitik asittir. Basit mideli hayvanlar ve

insanlar gastrointestinal fitaz enziminden yoksun oldukları için fitatı tam

olarak parçalayamaz ve fitat fosfatından yararlanamazlar. Ayrıca, fitik asit

beslenme karşıtı bir etki de göstermektedir, çünkü bazı metal iyonları ve

proteinlerle fizyolojik pH değerlerinde çözünmeyen kompleksler oluşturarak

bunların biyolojik kullanımını engellemektedir. Beslenme karşıtı etkisi, yapısındaki

fosforun kullanılamayıp atılmasıyla oluşan çevresel kirlilik ve gıdalara ekstra

fosfor ekleme gereksinimini ortaya çıkartması sebebiyle fitik asitin fitaz

enzimleri tarafından defosforilasyonu oldukça önemlidir. Fitazlar endüstriyel

olarak özellikle yem ve gıda sanayi olmak üzere çok çeşitli alanlarda kullanıma

sahiptirler. Farklı kaynaklardan elde edilebilen fitaz enzimleri içerisinde

endüstriyel ve biyoteknolojik uygulamalar için en uygun olanları mikrobiyal

fitazlardır. Termofilik fungusların ürettiği fitazlar, geniş pH aralığında

aktif olma, yüksek spesifik aktivite ve özellikle endüstriyel proseslerde

uygulanan yüksek sıcaklıklarda aktivitesini kaybetmemesini sağlayan

termostabilite gibi özelliklere sahiptirler. Bu yüzden mikrobiyal fitazlar

arasında oldukça önemli bir yere sahiptirler. Bu derlemede, fitaz enziminin

özellikleri, beslenme, insan sağlığı, çevresel açıdan önemi ve fitaz

kaynakları, kullanıldığı alanlar ele alınmıştır.
Particularismo histórico en una orientación metodológico relacional
Authors: Roth Senef Andrew
Published: April 2018

Reflexión sobre la obra de Alban Bensa
Implikasi corporate governance, investment opportunity set, firm size, dan leverage terhadap earnings quality
Authors: Nariman Augustpaosa , Ekadjaja Margarita
Published: April 2018

Profit of a company is used by creditor and investor to evaluate the performance of the management, estimate earnings power, and to predict future profit. Earning qualityis measured from the accrual. A company with high accrual is indicating that the quality of company profit is low, and vice versa. According to Chan,et al. (2001) profit quality in the financial report will increase company value which is reflected in the stock return. Purpose of the this research is to understand the impact of variable ofinstitutional shareholding, board size, board independence, investment opportunity set, firm size, and leverageto theearnings quality.  This research is using manufacturing industry that listed in the Indonesian stock exchange during the period of 2013-2016,sample is taken using purposive samplin technique.Based on analysis result and research is done using double linear regression with the eviews 9.0 software, we can conclude that there is a significant positive influence between institutional shareholding, board size, board independence, investment opportunity set, firm size, and leverageto the earnings quality. While leverage has insignificant influence to the earnings qualitymeasured with Discretionary Accruals (DACCR).
Pengaruh profitabilitas, ukuran perusahaan dan ukuran dewan komisaris terhadap pengungkapan tanggung jawab sosial perusahaan pada perusahaan manufaktur yang terdaftar di bursa efek indonesia
Authors: Chelsya Chelsya
Published: April 2018

This research aims to determine the factors that influence the level of Corporate Social Responsibility Disclosures by testing the effect of corporate size, profitability, and board of director size on corporate social responsibility disclosures index. Sample used are manufactur sector companies that listed on Indonesia Stock Exchange. The sources of the data were taken from audited financial reports and annual reports and sustainability report, if any. This research uses quantitative approach with multiple linier regression analysis. The results show that profitability, firms’ size and board of director size have a positive effect on corporate social responsibility disclosures.
Viticulture Biodiversity in Van Province
Authors: Gazioğlu Şensoy Ruhan İlknur , Doğan Adnan , Uyak Cuneyt , Keskin Nurhan
Published: April 2018

Viticulture preserved its significance from the past to the present that have been ruled in all civilization the region of Van. The presence of carbonized grape seeds in the remains of the Early Iron Age tombs and cities gives information about the history of grape cultivation in Van and its vicinities. However, many of the local varieties described by the elderly are now unfortunately not seen in large areas. Some of the genotypes are no longer encountered, while many genotypes are observed in a few vineyards with a few vines. The grape genetic resources except Erciş variety in the region are threatened with extinction. In spite of many ecological factors that restrict crop production in the region, vineyard has existed for thousands of years and urgent precautions have to be taken to protect this genetic heritage bearing grape landraces close to standard genotypes. The region has been investigated by many researchers for many years and the determined local varieties have been investigated in detail in terms of morphological and pomological characteristics, chemical contents and nutrients and defined in terms of molecular or ampelographic aspects in different studies. With this review, it is aimed to recover the knowledge of these genotypes in a single study in using scientific studies made up to this day in the region. So that it is aimed to lead the steps to be taken in the establishment of a gene pool composed of these local varieties which are under the risk of extinction is increasing day by day. The study also includes information on local adaptations of some standard grape cultivars that have been planted in previous years.
SEGURANÇA JURÍDICA, BOA-FÉ E TERRAS DEVOLUTAS
Authors: Nakamura Andre Luiz dos Santos
Published: April 2018

O presente trabalho pretende conceituar terras devolutas, o processo de discriminação, os efeitos da declaração de devolutividade e a necessidade de observância aos princípios da boa-fé e segurança jurídica pelo Estado.
O PRINCÍPIO DA VEDAÇÃO AO RETROCESSO SOCIAL E AS ALTERAÇÕES DOS REQUISITOS PARA A OBTENÇÃO DO BENEFÍCIO DO SEGURO-DESEMPREGO
Authors: Randal Pompeu Mota Beatriz , Rocha Dias Eduardo , Studart Leitão André
Published: April 2018

O presente estudo visa analisar as alterações nas regras para a concessão do benefício do seguro-desemprego trazidas pela Lei nº 13.134/2015, bem como verificar se as referidas mudanças ferem ou não o princípio da vedação ao retrocesso social. O desemprego involuntário é uma das contingências sociais prevista no inciso III do artigo 201 da Constituição Federal. Essa referência topográfica leva à interpretação de que o seguro-desemprego possui natureza de benefício previdenciário, enquadrando-se, portanto, no âmbito dos direitos sociais. Essas garantias, para serem concretizadas, necessitam de uma postura ativa do Estado, ou seja, o cumprimento desses preceitos constitucionais dar-se-á mediante a criação de políticas públicas, bem como legislação condizente, além do fornecimento de prestações. O princípio da vedação ao retrocesso social refere-se, por sua vez, à impossibilidade de o Estado alterar ou excluir direitos sociais já devidamente adquiridos pela sociedade. Sob essa perspectiva, o presente estudo pretende examinar se as novas regras para a concessão do benefício do seguro-desemprego conspurcam (ou não) o princípio da proibição do retrocesso social. Referida análise levará em consideração a situação econômica vivenciada no Brasil, assim como a dinâmica do mercado de trabalho formal brasileiro. No que se refere à metodologia aplicada, realizou-se pesquisa do tipo bibliográfica, uma vez que a investigação foi embasada em trabalhos publicados sob diversas formas, em especial, livros e artigos científicos.
A COMPATIBILIDADE ENTRE O EXERCÍCIO DE TRABALHO REMUNERADO PELO FILHO DEFICIENTE MENTAL E A PERCEPÇÃO DE PENSÃO POR MORTE NA ATUALIDADE
Authors: Paz Samuel Mota de Aquino
Published: April 2018

O presente artigo visa a perscrutar qual a implicação da supressão do §4° do Art. 77 da Lei 8.213/91 pela Lei 13.135/15, notadamente no intuito de analisar, na atualidade, a questão da compatibilidade do exercício do trabalho remunerado pelo maior deficiente mental/intelectual com a percepção do benefício de pensão por morte. A questão é de elevada importância na luta pela inclusão social do indivíduo portador de deficiência. Neste trabalho, buscou-se demonstrar que o atual estágio evolutivo de proteção ao deficiente parece não comportar intepretação condizente com um retrocesso nessa seara. A metodologia de trabalho baseou-se em pesquisa legal e bibliográfica.
A ARBITRAGEM NO DIREITO ADMINISTRATIVO
Authors: Aragão Alexandre Santos de
Published: April 2018

Embora a Lei nº 13.129/2015 tenha garantido, aos entes políticos e entidades administrativas em geral, a possibilidade de resolverem os seus conflitos por meio da arbitragem, ainda permanecem dúvidas relevantes e grande controvérsia, inclusive na jurisprudência, a respeito das matérias administrativas que podem ser apreciadas em instância arbitral. Além de delimitarmos, com a maior precisão possível, o campo de arbitrabilidade objetiva para as lides da Administração, examinaremos neste trabalho a arbitrabilidade das sanções e poderes contratuais unilaterais da contraparte pública (diferenciando tais prerrogativas ex contractu do poder de polícia), bem como a possibilidade de levar à arbitragem os efeitos meramente pecuniários de direitos indisponíveis ou extrapatrimoniais. Por fim, analisaremos a possibilidade (e a conveniência) de se densificar, por meio de atos normativos regulamentares ou dos próprios contratos, o que se deve entender por “direitos patrimoniais disponíveis” para fixação das matérias que podem ou não ser apreciadas em arbitragens envolvendo o Estado.
A CONSTITUCIONALIDADE DO ART. 30, INCISO IX, DA LEI 8.212/91 QUE PREVÊ HIPÓTESE DE RESPONSABILIDADE TRIBUTÁRIA DE MEMBROS DE UM MESMO GRUPO ECONÔMICO POR DÉBITO PARA COM A SEGURIDADE SOCIAL
Authors: Noger Renata Melo
Published: April 2018

RESUMOÉ notória a necessidade de se assegurar a eficiência na arrecadação tributária do país, tendo em vista principalmente o fato de que é dos seus orçamentos que os Entes da Federação retiram verba para custear políticas públicas que visem a implementar direitos e garantias individuais na área da saúde, previdência e assistência social, tal qual preconiza o art. 195 da Constituição Federal.O presente trabalho se propõe a analisar a constitucionalidade do inciso IX do art. 30 da Lei nº 8.212/61, que autoriza a atribuição de responsabilidade tributária solidária a pessoas jurídicas de um mesmo grupo econômico por débitos de qualquer de seus membros para com a Seguridade Social e amplia a eficiência da arrecadação tributária, na medida em que amplia os sujeitos passivos da obrigação e, conseqüentemente, o universo patrimonial penhorável.
A IDEIA DE RESPONSABILIDADE CRIMINAL INDIVIDUAL INTERNACIONAL PRESENTE NO ESTATUTO DE ROMA
Authors: Da Cunha Soares Júnior Wolney
Published: April 2018

Os crimes internacionais surgem de tratados celebrados entre os Estados que condenam a prática de determinado ato e se comprometem a combatê-los. Para tanto, o direito penal interno é de grande importância, pois ele regulamenta essa repressão aos crimes internacionais no âmbito de cada Estado. Pode, no entanto, ocorrer essa repressão por meio de tribunais internacionais, como é o caso do Tribunal Penal Internacional, cujo Estatuto de Roma institui uma verdadeira responsabilidade criminal individual internacional. A vedação à utilização de imunidades perante o TPI reflete a tendência do Direito Internacional de dar primazia à responsabilidade criminal individual no caso de crimes internacionais, não podendo ser esses últimos entendidos como tendo sido praticados dentro da capacidade oficial de um agente do Estado. Não subsistem as alegações de ilegalidade do TPI diante da possibilidade de exercer a sua jurisdição sobre nacionais de Estados que não ratificaram o Estatuto de Roma, inexistindo qualquer violação ao Direito costumeiro e ao princípio do pacta tertiis, segundo o qual um tratado não poderia criar obrigações para terceiros Estados. Afinal, aquele tribunal internacional julga pessoas e não Estados.
MEIO AMBIENTE E REDUÇÃO DAS DESIGUALDADES E DA POBREZA
Authors: Henrique Lisiane Aguiar , Bizawu Sébastien Kiwonghi
Published: April 2018

O artigo discorre sobre a questão social da pobreza e da desigualdade, a partir da percepção do próprio meio ambiente e seus elementos, interações e relações. Numa abordagem solidária, o entrelaçamento de todos os seres, povos e gerações, na preservação da existência sadia, traz a concepção da sustentabilidade. A complexidade ambiental que se verá abarca tanto as mudanças ecossistêmicas quanto os desafios sociais, não podendo haver negligência ambiental ou miserabilidade consentida. Os problemas socioambientais são resultado de práticas depredadoras lucrativas, à custa dos sistemas naturais e sociais. Intrinsecamente ao meio ambiente, surge a problemática social, na verdade, sob duas vertentes, aquela que no  processo de escolha gera a degradação ambiental e aquela que lhe é produto. Utilizando-se o método dedutivo, com ênfase na pesquisa exploratória, ver-se-á a preocupação de se devolver a dignidade aos empobrecidos, excluídos, famélicos, a partir do momento em que se vê a necessidade de se revivificar os direitos humanos a partir do próprio direito ambiental. A qualidade de vida digna, abordada na temática da pobreza, pressupõe repensar valores, inclusive, para além do fisicalismo estritamente material, trazendo a atenção para a autonomia, integração, diversidade e respeitabilidade, nos processos de relações sociais. O desafio é enfrentar a desigualdade possibilitando a participação dos marginalizados nas discussões e propalando uma cultura ambiental.
BREVES APONTAMENTOS SOBRE A PRINCIPAL OBRA DE HANS-GEORG GADAMER: A VERDADE NÃO É QUESTÃO DE MÉTODO
Authors: Paula Ana Cláudia Fagundes Oliveira Nobre Zanoni de
Published: April 2018

Hans-Georg Gadamer é essencial no desenvolvimento da hermenêutica no século XX. Influenciado por Martin Heidegger, ele demonstrou, na obra em apreço, a natureza da compreensão humana, e que a linguagem passa a ser vista, com o giro linguístico, como meio para a compreensão do indivíduo no mundo. Ele se apoia nos ensinamentos de Heidegger no sentido do sujeito estar imerso em um contexto histórico-linguístico, que molda e fornece um horizonte de sentidos para se chegar a verdade em um ato interpretativo. Para tanto, Gadamer diz que a interpretação se dá a partir da existência de pré-juízos, e é em função da tradição que o intérprete fala o Direito e do Direito, formando, assim, interpretações mais adequadas.
CONSIDERAÇÕES JURISPRUDENCIAIS DO SUPERIOR TRIBUNAL DE JUSTIÇA SOBRE A IMPENHORABILIDADE DO BEM DE FAMÍLIA LEGAL À LUZ DOS PRINCÍPIOS DA DIGNIDADE DA PESSOA HUMANA E DA PROTEÇÃO À MORADIA
Authors: Batista Fernando Natal
Published: April 2018

O presente artigo tem como proposta abordar o tema da impenhorabilidade do bem de família legal (Lei n.º 8.009/1990) sob o prisma da Constituição Federal de 1988, mormente à luz dos princípios da dignidade da pessoa humana, da proteção à família e à moradia, restringindo, todavia, para fins metodológicos, em sua análise, ao âmbito da construção jurisprudencial gradualmente estabelecida pelo Superior Tribunal de Justiça - STJ. A partir do exame jurisprudencial do bem de família legal, mediante a indicação e o estudo de julgados daquela Corte, percebe-se o movimento de constitucionalização do direito civil (verticalização dos direitos fundamentais nas relações privadas), surgido após a promulgação da Carta Política de 1988, no intuito de proteger o patrimônio existencial digno do indivíduo nas relações civis, em detrimento de direitos creditórios.
O PRINCÍPIO DO NÃO-CONFISCO EM MATÉRIA TRIBUTÁRIA, DIREITOS FUNDAMENTAIS E O POSICIONAMENTO DO SUPREMO TRIBUNAL FEDERAL
Authors: Simini Danilo Garnica , Vezzani Camila Saran , Henrique Machado Carlos
Published: April 2018

O presente trabalho buscou demonstrar a importância do citado princípio, especialmente, no que diz respeito à sua relação com os direitos e garantias fundamentais do cidadão. Sendo assim, foi apresentada a conceituação do princípio do não-confisco, seus desdobramentos e a sua cronologia histórica dentro de nosso ordenamento jurídico. Constatou-se que o princípio carece de certa precisão, competindo ao Poder Judiciário fixar os devidos limites e parâmetros, especialmente, o Supremo Tribunal Federal. Por isso, mostrou-se importante investigar o posicionamento da Suprema Corte em relação citado princípio. Foi realizada uma revisão da bibliografia e pesquisa de jurisprudência junto ao Supremo Tribunal Federal, tendo se concluído que a atuação do Supremo Tribunal Federal é importante em relação à fixação de limites e parâmetros para a aplicação prática do princípio, mas também os mesmos parâmetros adotados pelo Tribunal acabam por prejudicar a análise da violação ou não ao princípio do confisco em determinadas matérias.
US Security Concerns in Africa: An Afrocentric Perspective
Authors: Shai Kgothatso Brucely , Sodi Tholene , Molapo Rachidi R.
Published: April 2018

This qualitative article employs an Afrocentric perspective as an alternative theoretical and/or contextual lens to provide an overview of the national security challenges facing the United States of America (US) within the context of its engagement in Africa. It also demonstrates the reactions of the US to African security threats (real or imagined) to its national well-being. At the centre of the discussion of this article is the articulation of the main issues about the US National Security Strategy in relation to Africa. The objective is to unravel the myth that Africa is a threat to the US national security and the reality about its dismissed importance to US within the context of the current global discourse on security. In order to provide a wider context for understanding the security dimension of the US foreign policy as it relates to Africa and to foster epistemic justice, it is important to address this subject from the viewpoint of Africans and others whose fate is tied to this continent.Â Â
The Effects of Intrastate War and Reintegration on Liberian Child Soldiers: Part II
Authors: Ferreira Rialize , Mutiti Alfred
Published: April 2018

The main focus of this article is on the effects of intrastate war and the reintegration of Liberian child soldiers into their families and former communities. In this context, legal frameworks for the protection of children, types of recruitment (forced, persuasive, and â€œvoluntaryâ€), reasons for recruitment, and the need for personal protection are dealt with. Also discussed are disarmament, demobilisation and reintegration processes, roles of communities, provision of psycho-social support and care to reintegrated child soldiers, the physical, social and emotional effects they experience, their reintegration into communities, social networks, the disengagement of children from former commanders, and the skills training options provided to these children. In this empirical, qualitative study, primary data was obtained from focus group discussions and semi-structured interviews, and secondary data was obtained from documentary sources. Some of the primary data substantiated the secondary data, confirming the finding that war caused profound damage and heartache but that it also helped children to become resilient. The study found that the brutal effects of war, culminating in the reintegration of child soldiers into communities, manifested themselves over many years.
Real-time capable virtual NOx sensor for diesel engines based on a two-Zone thermodynamic model
Authors: Vihar Rok , Baškovič Urban Žvar , Katrašnik Tomaž
Published: April 2018

This paper presents a control-oriented thermodynamic model capable of predicting nitrogen oxides (NOx) emissions in diesel engines. It is derived from zero-dimensional combustion model using in-cylinder pressure as the input. The methodology is based on a two-zone thermodynamic model which divides the combustion chamber into a burned and unburned gas zone. The original contribution of proposed method arises from: (1) application of a detailed two-zone modeling framework, developed in a way that the thermodynamic equations could be solved in a closed form without iterative procedure, which provides the basis for achieving high level of predictiveness, on the level of real-time capable models and (2) introduction of relative air-fuel ratio during combustion as a main and physically motivated calibration parameter of the NOx model. The model was calibrated and validated using data sets recorded in two different direct injection diesel engines, i.e. a light and a heavy-duty engine. The model is suitable for real-time applications since it takes less than a cycle to complete the entire closed cycle thermodynamic calculation including NOx prediction, which opens the possibility of integration in the engine control unit for closed-loop or feed-forward control.
Effect of pH and Ageing Time in the Preparation of A Ceramic Drug Delivery Carrier
Authors: Swamiappan Sasikumar
Published: April 2018

Hydroxyapatite is the inorganic constituent present in the bone and it is used as a drug delivery carrier in hard tissue regeneration applications. Hydroxyapatite was prepared by simple precipitation technique and the effect of experimental parameters on the phase formation was studied. Calcium nitrate tetra hydrate and diammonium hydrogen phosphate were taken as the calcium and phosphate source. The calcined powders were characterized by Fourier - Transform Infrared spectroscopy to identify the functional groups present in the product and also analyzed by powder X-ray diffraction to identify the phases present in the product. Results showed that the product formed is pure hydroxyapatite and it confirms that aging time and pH of the system plays a significant role in the phase formation.Keywords: Hydroxyapatite, Aging time, pH, Precipitation technique, Powder XRD; Ceramic Drug Delivery Carrier.
Transformation of Library Space: Opinion of Urban Citizens
Authors: Kuchmurukova Ekaterina A. , Rinchinova Yulia S.
Published: April 2018

The role of libraries in the urban cultural landscape is determined. The authors consider the problem of city branding, analyse the main publications on the studied subject, describe the major factors influencing the formation of urban space, define the specific features of the urban culture, in formation of which the important role play the cultural institutions which are responsible for the leisure activities sphere.

Indicating the problem of no demand of the services provided by cultural institutions, there are characterized the normative documents that determine the directions and prospects for the development of public libraries. It is emphasized that in modern conditions there is a discrepancy between the needs of young citizens and the services offered in the information market. This leads to the outflow of readers from libraries and to the lack of interest to the events arranged by them.

Using the example of Ulan-Ude city, the capital of the Republic of Buryatia, there are analysed operating procedures of city libraries and considered the questions of space organization of the modern library.

There are presented the results of survey, where the main objective is studying the opinion of citizens about the place of libraries in modern society. There are summarized the results of the Round table devoted to the problems of organization of library space, the culture of reading of urban citizens and professional growth of library personnel, held by the Ulan-Ude Central City Library named after I.K. Kalashnikov and the East-Siberian State Institute of Culture.
To the Question of the Balanced Scorecard System Modelling in the Context of Libraries (Using the Example of the Republican Medical Library-Information Center)
Authors: Dresher Julia N. , Kosolapova Evgenia A.
Published: April 2018

Balanced scorecard (BSC) is widely used to achieve strategic objectives, ensure the efficient operation and successful development of enterprises, institutions and organizations. Multiple information sources describe different approaches to BSC design and models created on the basis of these approaches. Introduction and subsequent functioning of the Quality management system in the Republican Medical Library-Information Center (RMLIC) in Kazan (Republic of Tatarstan) has led to the need for such BSC in the institution, which would have ensured the proper quality of its products and services. However, the analysis of publications revealed the absence of the models for bibliographic and information activities suitable for practical use at the moment.

It was decided to develop the conceptual model of BSC, basing on the international and own experience and considering specific features of RMLIC area. The article describes the advantages and disadvantages of a number of models and approaches to the construction of BSC, the basic provisions and main principles of designing conceptual model of such system for bibliographic and information activities. The opinion is expressed that synergetic approach allows to create a model, providing fine and well-tuned strategy, formation of key performance indicators that contributes to improve the activities of institution engaged in the provision of library-bibliographic and information services.

The author’s conceptual model of the balanced scorecard is presented graphically and described in detail. It meets the needs of RMLIC and logically fits into the control system of the institution operating in the conditions of continuous improvement of the Quality management system.
Seminar “Information Provision of Science: New Technologies” and the History of Library Automation
Authors: Kalenov Nikolay Е.
Published: April 2018

The first professional standing Seminar “Information Provision of Science: New Technologies” has been held regularly since 1985. It is the platform for the library personnel, information workers and programmers to discuss the questions of development of the modern computer technologies for solution of library-information problems. Collections of materials of all seminars are published in printed form and presented on the website of the Library for Natural Sciences of the Russian Academy of Sciences (BEN RAS).

The article considers the situation in the field of the development of computer technology, existed in the mid-1980-ies that caused the need to organize the Seminar. There are presented the results of the analysis of Seminar proceedings published in 1985—2017, allowing to trace the development of library automation in the country. There is estimated the frequency of usage in the headings of reports of different terms related to this problem, that characterizes the dynamics of changes of its main priorities. Thus, the term ECM was widely used in 1980-ies, since 1991 ceased to be used; the term “electronic library”, which appeared in the proceedings of Seminar in 1999, reached its peak use in the late 2000-s, and then became quite “usual”; now in the titles of reports it appears much less frequently.