bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and Drug Consumption Habits at the 2011 Peninsula Festival in Tîrgu Mureș
Authors: L Domokos , Z Ábrám , Sz Sebesi , Hajnal Finta
Published: March 2014

Introduction: In 2010 Romania was ranked fourth in the European Union regarding the prevalence of ethnobotanical drug use with psychotropic effect. The main purpose of our survey was to collect data on substance use and assess drug consumption habits among participants at the 2011 Peninsula Music Festival in Tîrgu Mureș, Romania. Material and method: The study was carried out as a cross-sectional survey in a sample of 256 persons, using an anonymous, self-administered structured questionnaire, containing questions about the consumption patterns of illegal psychoactive drugs, as well as sociodemographic data which could influence drug consumption (age, gender, educational level, marital status of parents). Results: Ethnobotanical drug consumption had the highest lifetime prevalence (37.7%), the second most often used drug was cannabis (marijuana) with a lifetime prevalence of 35.2%. Males and females differed significantly in the use of marijuana (p = 0.023) and ethnobotanical drugs (p = 0.008) in the last 12 months, male respondents used more of these psychoactive substances. In the case of children with divorced parents the last 12 months marijuana use (p = 0.032) and ethnobotanical drug use (p = 0.013) was significantly higher than in the case of children whose parents were not divorced. Conclusions: The survey results show the importance of the development of health education programs and drug-prevention strategies for vulnerable goups (festival visitors, minors, children with divorced parents)
Assessing the Patient with Abdominal Obesity: Metabolic and Nutritional Factors
Authors: Raluca Pop , M Pop , G Dogaru
Published: March 2014

Background: Abdominal obesity is a confirmed cardio-vascular risk factor and the elements influencing it are subject for research and intervention. The available nutritional evaluation methods are time consuming, subjective and a standardized approach is missing. Aim: Standardized evaluation of patients with abdominal obesity. Material and methods: Cross-sectional study on a convenience sample of 85 subjects who presented in the Endocrinology Outpatient Clinic of the Emergency Mures County Hospital between February - April 2013. Variables: age, sex, environment, BMI, waist, blood glucose, triglycerides, HDL-Cholesterol, blood pressure. Each patient filled a food frequency questionnaire. Results: None of the subjects had a “normal” food pyramid. Sex has no influence on the food pyramid. The meat and protein food group is the only one significantly influenced by the environment (p = 0.04). Patients with dyslipidemia consume lower amounts of sweets (1.13 vs. 1.83 servings, p = 0.007). Patients requiring metabolic treatment have significant higher waist values (101.32 vs. 93.07 cm, p=0.03). Patients with simple abdominal obesity consume significant lower amounts of meat and protein and higher amounts of fruit and vegetables. Conclusions: A standardized approach to the patient with abdominal obesity using nutritional assessment tools and metabolic evaluation helps to identify those at risk and to give more tailored recommendations
Correlations Between Regional Accumulation of Calcium in the Culprit Arteries and Plaque Burden in Acute Coronary Syndromes
Authors: Beáta Jakó , Theodora Benedek , Zsuzsanna Suciu , I Benedek
Published: March 2014

Introduction: The association between a high calcium score at the level of the unstable coronary lesions and the different characteristic of culprit lesions which result in an acute coronary syndrome (ACS) has not been described yet. We aimed to study the correlation between the accumulation of calcium within the vessel wall of a coronary artery and the plaque burden of culprit lesions that develop an acute coronary event. Material and methods: A total of 45 patients with ACS (22 unstable angina, 23 nonST elevation myocardial infarction) underwent 64-slice CCTA. In all patients a complex CT analysis of the culprit plaques was performed and the calcium score for each coronary artery was computed. Results: We found a significant correlation between a calcium score higher than 100 and the plaque volume (r = 0.85. p = 0.01). Selecting a cut-off value of 100 HU for regional calcium score at the level of the coronary artery, we found that those arteries with Ca score higher than 100 presented significantly larger plaque volumes than the ones with calcium score below 100 (110.8 ml vs 82.4 ml, p <0.0001 for left anterior descending artery, 111.09 ml vs 82.5 ml, p = 0.0005 for circumflex artery, and 132.78 ml vs 76.23 ml for right coronary artery). Conclusion: Our data shows that in ACS, the severity of the culprit lesions correlates with regional accumulation of calcium within the vessel wall.
Surrogate Measures of Insulin Resistance in Middle-aged Non-diabetic Subjects
Authors: Katalin Csép
Published: March 2014

Objective: Insulin resistance has been shown to be a risk factor for type 2 diabetes and cardiovascular disease. The assessment of insulin sensitivity in the clinical practice, however, faces several difficulties. The study proposes to analyze surrogate measures of insulin resistance based on fasting insulin levels in central Romania, and check whether the diagnosis of the metabolic syndrome is an adequate strategy to identify middle-aged persons with reduced insulin sensitivity. Methods: Anthropometric measurements, metabolic profile, and surrogates measures of insulin sensitivity (GIR, HOMA, QUICKI, FIRI, Belfiore, Bennett, Raynaud, McAuley index) based on fasting insulin levels were assessed in 233 non-diabetic middle aged subjects. Results: Cutoff values, determined as the lowest quartile of insulin sensitivity for fasting insulin, HOMA, IRI (1/QUICKI), FIRI and Belfiore's, Bennett's, Raynaud's and McAuley's insulin sensitivity indices were 10.49 mU/L, 2.1, 3.01, 2.32, and 0.03, 1.34, 3.81, 6.29, 5.82. Components of the metabolic syndrome showed moderate but significant correlations with the surrogate measures of insulin resistance (r = 0.22-0.56, p <0.05). HOMA-IR and McAuley indices were the best predictors of clustered cardiometabolic risk factors (AUC - 0.83, 0.81 and 0.82). The metabolic syndrome diagnosis performed well in identifying patients with reduced insulin sensitivity (McAuley 2: sensitivity - 0.78, specificity - 0.84). Conclusion: Fasting insulin derived insulin sensitivity indices may help the recognittion of insulin resistant states predicting cardiometabolic disorders. Actively looking for insulin resistance by these simple indices, or by diagnosing the metabolic syndrome, those at increased risk can be recognized
Considerations Regarding Age at Surgery and Fistula Incidence Using One- and Two-stage Closure for Cleft Palate
Authors: Simona Stoicescu , Dm Enescu
Published: March 2014

Introduction: Although cleft lip and palate (CLP) is one of the most common congenital malformations, occurring in 1 in 700 live births, there is still no generally accepted treatment protocol. Numerous surgical techniques have been described for cleft palate repair; these techniques can be divided into one-stage (one operation) cleft palate repair and two-stage cleft palate closure. The aim of this study is to present our cleft palate team experience in using the two-stage cleft palate closure and the clinical outcomes in terms of oronasal fistula rate. Material and methods: A retrospective analysis was performed on medical records of 80 patients who underwent palate repair over a five-year period, from 2008 to 2012. All cleft palate patients were incorporated. Information on patient’s gender, cleft type, age at repair, one- or two-stage cleft palate repair were collected and analyzed. Results: Fifty-three (66%) and twenty-seven (34%) patients underwent two-stage and one-stage repair, respectively. According to Veau classification, more than 60% of them were Veau III and IV, associating cleft lip to cleft palate. Fistula occurred in 34% of the two-stage repairs versus 7% of one-stage repairs, with an overall incidence of 24%. Conclusions: Our study has shown that a two-stage cleft palate closure has a higher rate of fistula formation when compared with the one-stage repair. Two-stage repair is the protocol of choice in wide complete cleft lip and palate cases, while one-stage procedure is a good option for cleft palate alone, or some specific cleft lip and palate cases (narrow cleft palate, older age at surgery)
Cardiac Computed Tomography Angiography for Imaging Coronary Arteriovenous Malformation: a Case Report
Authors: Zsuzsanna Suciu , Beáta Jakó , Theodora Benedek , I Benedek
Published: March 2014

Background: Coronary arteriovenous malformation is a rare congenital disease consisting mainly in a direct communication between a coronary artery and any one of the four cardiac chambers, coronary sinus, pulmonary arteries or veins. This disease can lead to various cardiovascular events, their severity depending on the degree of the malformation. Case report: We present the case of a 56-year-old male patient, who was admitted to our institution with dyspnea, palpitation and chest pain, having a history of hypertension and hyperlipidemia, and an abnormal electrocardiogram. Physical examination did not reveal any alterations and the cardiac enzymes were in normal ranges. Cardiac computed tomography was performed before any other invasive studies, with a 64-row scanner (Somatom Sensation multislice 64 equipment, Siemens) after intravenous administration of non-ionic contrast material. CT scan revealed a large (2-2.5 mm) coronary fistula originating from the LAD to the main pulmonary artery, and multiple significant atherosclerotic coronary lesions. Coronary angiography confirmed the arteriovenous malformation between LAD and pulmonary artery, associated with three vascular coronary artery disease. Conclusions: Cardiac computed tomography angiography can help for a non-invasive diagnosis of the coronary artery malformations, in the same time revealing anatomic details which can be particulary useful for choosing the appropriate management strategy (surgical planning, interventional treatment or optimum medical treatment)
Effects of nonlinearity on determination of bolt forces for the operational state of a bolted flange connection
Authors: Grzejda R.
Published: March 2014

Modelling and calculations of an asymmetrical bolted flange connection at the operational stage are presented. The physical model of the joint is based on a flexible flange element that is connected with a rigid support by means of hybrid elements, which substitute bolts. Between the flange element and the support, the linear Winkler model of a contact layer is taken into account. The bolted flange connection is preloaded and then subjected to an eccentric normal load. The influence of nonlinearity of the contact layer between the joined elements on computational values of bolt forces has been investigated. Results of calculations for several different values of the joined element’s thickness are described
A derivation of the generalized model of strains during bending of metal tubes at bending machines
Authors: Śloderbach Z.
Published: March 2014

According to the postulate concerning a local change of the “actual active radius” with a bending angle in the bend zone, a generalized model of strain during metal tube bending was derived. The tubes should be subjected to bending at tube bending machines by the method of wrapping at the rotating template and with the use of a lubricated steel mandrel. The model is represented by three components of strain in the analytic form, including displacement of the neutral axis. Generalization of the model during bending metal tubes at the tube bending machines as compared with the existing papers (Śloderbach, 1999; Śloderbach and Rechul, 2000) consists in including the neutral axis displacement and possibility of determination of strains at each point along the thickness of the wall of the bent tube in the bending and bend zone. The derived scheme of strain satisfies initial and boundary kinematic conditions of the bending process, conditions of continuity and inseparability of strains. The obtained analytic expressions can be classified as acceptable from the kinematic point of view
The north atlantic oscillation and winter precipitation totals in Slovakia
Authors: Lívia Labudová , Šťastný Pavel , Trizna Milan
Published: March 2014

The North Atlantic Oscillation (NAO) is the most important circulation phenomenon in the Northern Atlantic which impacts climate in Europe in various ways. Precipitation is a basic climatic element which affects the landscape significantly. Therefore in this paper, the relationship between the NAO and winter precipitation in Slovakia is analysed. A Spearman’s correlation analysis was used, which detected the impacts of NAO on the above-mentioned seasonal precipitation in different regions of Slovakia. The correlation coefficients obtained positive values in the region of Orava and Kysuce and changed to negative ones in a southward direction. The detected zonal configuration can be explained by the topographic barrier effect of the Carpathians
Development of an effective extraction process for coenzyme Q10 from Artemia
Authors: Rujiralai Thitima , Raekasin Nirundorn , Cheewasedtham Wilairat , Cheewasedtham Chonlatee
Published: March 2014

A method for extracting coenzyme Q10 (CoQ10) from Artemia was developed. 1 g of fresh Artemia was incubated with 75 % acetic acid at (30 ± 2)°C for 24 h, followed by three consecutive extractions with a mixture of 5 mL of hexane and 5 mL of ethanol, then analysis by a validated high-performance liquid chromatography with a diode-array detector. The calibration curve for CoQ10 was linear in a range of 1–50 μg mL−1. The limits of detection and quantification were 0.3 μg mL−1 and 1.1 μg mL−1, respectively. Mean recoveries were 94–100 % with a high precision of below 10 %. The method developed was found to be simple, efficient and the time required for releasing CoQ10 from Artemia was short. The method provides not only low energy consumption but is also practical for industrial applications.
Candida albicans isolated from post-operative penetrating keratoplasty patient: Case report
Authors: Chandra Abhishek , Gupta Munesh Kumar , Tilak Ragini
Published: March 2014

We report a case report of Candida albicans suture infiltrate on 3rd post-op day in a 53 year female operated for penetrating keratoplasty. Candida albicans was identified by KOH mount, Gram Staining, germ tube, growth at 450C, chlamydospore formation and light green color on CHROMagar with sugar assimilation and culture characteristics. Despite being susceptible to Fluconazole by broth microdilution, patient did not respond to 0.3% fluconazole eye drops. On antifungal susceptibility testing by CLSI44A, it was susceptible to only Amphotericin B (100units). Patient was then started on 0.15% fortified amphotericin B eye drops resulting in complete resolution of infiltrates. Asian Journal of Medical Science, Volume-5(3) 2014: 116-119 http://dx.doi.org/10.3126/ajms.v5i3.8669
Pulmonary hamartoma, a rare benign tumour of the lung - Case series
Authors: Tyagi Ruchita , Bal Amamjit , Mahajan Divyesh , Nijhawan Raje , Das Ashim
Published: March 2014

Introduction - Pulmonary hamartoma, with incidence of 0.25-0.32%, accounts for 6% of solitary pulmonary nodules. The role of radiology is limited as only 10-30% of cases show characteristic ‘popcorn’ calcification and Computed Tomography can detect approximately  50% of hamartomas. Hence cytological and/or histopathological examination is required to make a definitive diagnosis and exclude malignancy. Objective – As pulmonary hamartoma is a rare entity detected serendipitously on radiography and requires cytological and histopathological examination for confirmation of diagnosis, we present nine cases of solitary pulmonary nodules which were diagnosed as pulmonary hamartoma.  Methods - We retrospectively screened departmental records and slides and found nine cases of pulmonary hamartoma in our tertiary care institute. Three cases were diagnosed on CT guided Fine Needle Aspiration Cytology and four cases were diagnosed on histopathological examination of surgical specimens, over a period of 16 years (1997-2012). Two cases were incidentally discovered to have pulmonary hamartoma at autopsy.  Observations – The age of the patients ranged from 17-63 years (mean-46.3), with male to female ratio being 3.5:1. The size of the hamartoma varied from 0.4 – 1.3 cm, with mean diameter of 1 cm. Cytology showed mixture of bronchial epithelial cells, adipocytes and stromal fragments in fibromyxoid and chondroid background. Histopathology demonstrated lobules of cartilage and adipose tissue with intervening clefts lined by respiratory epithelium and mesenchymal stroma. Conclusion – Every solitary pulmonary nodule is not malignant. It is important to correctly diagnose pulmonary hamartoma, a rare, yet benign neoplasm presenting as a solitary lung nodule and distinguish it from malignancy.Asian Journal of Medical Science, Volume-5(3) 2014: 112-115 http://dx.doi.org/10.3126/ajms.v5i3.9243
Ringed sideroblasts in HIV infection - A rare phenomenon
Authors: Madan Neha Kawatra
Published: March 2014

No abstract available.Asian Journal of Medical Science, Volume-5(3) 2014: 123-124 http://dx.doi.org/10.3126/ajms.v5i3.9349
Incidental mucosal abnormalities of paranasal sinus in patients referred for MRI brain for suspected intracranial pathology in Eastern Nepal
Authors: Gupta Mukesh Kumar , Rauniyar Raj Kumar , Ahmad Kaleem , Ansari Sajid , Pant Ashok Raj
Published: March 2014

Background: Mucosal abnormalities of the paranasal sinuses are frequently encountered as incidental findings during MRI evaluation of brain, however, little is known about their magnitude and spectrum in the Nepalese population. The purpose of this study was to analyze the spectrum of incidental mucosal abnormalities of paranasal sinuses in patients who had undergone MRI of brain for suspected intracranial pathologies. Methods: A retrospective cross-sectional study was conducted on 600 consecutive patients referred for brain MRI with suspicion of intracranial pathologies over a period of two years. The mucosal abnormalities of paranasal sinuses were evaluated and the findings were categorized according to the anatomic location and the imaging features of the abnormality seen on MRI. Results: Of total 600 cases, sinus abnormality was seen in 349(58.2%) patients. The spectrum of sinus abnormalities in 349 patients was as follows: mucosal thickening - 313(89.7%), polyp/retention cyst - 139(39.8%), sinus opacification - 114(32.7%), and fluid level - 23(6.6%). Maxillary sinus was involved in 291(83.4%) followed by ethmoid in 257(73.6%), frontal in 169(48.4%) and sphenoid sinus in 115(33.0%) cases. Conclusion: Incidental mucosal abnormalities of paranasal sinus are common findings on MRI performed for evaluation of intracranial pathologies. Mucosal thickening is the commonest abnormality and the maxillary sinus is the most commonly affected sinus. Such a high prevalence of incidental abnormality suggests some unidentified subtle environmental allergens in this part of Nepal and the condition may reflect initial findings of allergic rhinosinusitis before it progresses to the full-fledged symptomatic stage. Asian Journal of Medical Science, Volume-5(3) 2014: 40-44 http://dx.doi.org/10.3126/ajms.v5i3.9929
Female Age at Marriage and Their Fertility in Tharu Community
Authors: Yadav Rajkumar
Published: March 2014

The main objective of this article is to study the age at marriage and their fertility (CEB) based on secondary data. The data were collected by M.A. Population Studies student Mr. Pramanand Chaudhary. He had selected the Tharu community of ward no.5,6 and 8 of Sundarpur VDC of Sarlahi district as a study area in 2006. This article tries to deal with age group, educational status, occupational status, types of family of respondents and their mean age at marriage. Similarly age at marriage educational status, occupational status of respondents and their mean children ever born (CEB) from the selected respondents. Household and respondents were selected with the help of purposive method where the prevalence of the female age at marriage in Tharu community was high. Collected data were analyzed on the basis of table, frequency distribution, percentage and simple statistics.Academic Voices, Vol. 3, No. 1, 2013, Pages 33-39   DOI: http://dx.doi.org/10.3126/av.v3i1.9982
Insecticidal and Antimicrobial Activity of Triaryl Antimony(V) Derivatives
Authors: Yadav Ram Nath Prasad
Published: March 2014

This paper is devoted to the biological activity of the triaryl antimony(V) derivatives which deals with insecticidal and antimicrobial activity of tris(pentafluorophenyl)antimony(V) amides, (Rf)3SbL2 (Rf = C6F5; L = NR2: and triaryl antimony(V) carboxylates, Ar3SbL2 (Ar = C6H5, p-CH3C6H4; L = OCOR. All the compounds were found to exhibit moderate to significant biological activity against P. americana (insect), P. auriginosa, S. Aurens and K. Pneumoniae (bacteria), Synnhemp Rosette (virus), Tobacco Mosaic (Virus) and A. niger, A. flavus and E. moniliforme (Fungus). The compounds with fluoro and amide groups are highly active than that of compounds with phenyl, tolyl and carboxylate groups.Academic Voices, Vol. 3, No. 1, 2013, Pages 40-45 DOI: http://dx.doi.org/10.3126/av.v3i1.9983
Students' Conflict in Schools
Authors: Thapa Tara Bahadur
Published: March 2014

This paper is focused on students' conflict in schools and its main propose is to explore the causes and effects of students' conflict in school level. The result revealed that the majority of the students' are included by any types of the conflicts. Reasons for such conflict were: interest of opposite sex, aggressive behavior, teaching learning process and other activities like difference in individual capabilities, difference in their socio-economic backgrounds at home. It was also noted that bulling factors also cause of conflicts and girls are more victimized. The study would help students, teachers, school administrators and academicians as well as policy makers.Academic Voices, Vol. 3, No. 1, 2013, Pages 76-80   DOI: http://dx.doi.org/10.3126/av.v3i1.9991
Topographic and geometric controls on glacier changes in the central Tien Shan, China, since the Little Ice Age
Authors: Li Yanan , Li Yingkui
Published: March 2014

This paper examines the topographic and geometric controls on glacier changes in area and equilibrium-line altitude (ELA) in the central Tien Shan, China, since the Little Ice Age (LIA). We delineate the extents of 487 modern glaciers and their corresponding maximum LIA glacial advances using satellite imagery in Google Earth, and analyze the relationships between the magnitude of glacier changes and a set of local topographic/geometric factors including glacier area, slope, aspect, shape, hypsometry and mean elevation. Our results show that: (1) glacier area decreased from 460.2 km2 during the LIA to 265.6 km2 in the 2000s (a loss of 42.3%), with an average ELA increase of ~100m; (2) relative area changes of glaciers are strongly affected by two of these local factors (glacier area and mean elevation); and (3) ELA change does not show a strong relationship with local factors, suggesting that it may be controlled mainly by climatic factors. This study provides important insights into the local controls on glacier changes at the centennial timescale, which are of critical importance to assess future glacier changes in this arid and semi-arid region.
Analysis of Solar Neutrino Data from Super-Kamiokande I and II
Authors: Haubold Hans , Mathai Arak , Saxena Ram
Published: March 2014

We are going back to the roots of the original solar neutrino problem: the analysis of data from solar neutrino experiments. The application of standard deviation analysis (SDA) and diffusion entropy analysis (DEA) to the Super-Kamiokande I and II data reveals that they represent a non-Gaussian signal. The Hurst exponent is different from the scaling exponent of the probability density function, and both the Hurst exponent and scaling exponent of the probability density function of the Super-Kamiokande data deviate considerably from the value of 0.5, which indicates that the statistics of the underlying phenomenon is anomalous. To develop a road to the possible interpretation of this finding, we utilize Mathai’s pathway model and consider fractional reaction and fractional diffusion as possible explanations of the non-Gaussian content of the Super-Kamiokande data.
Spatial Point Pattern Analysis of Human Settlements and Geographical Associations in Eastern Coastal China — A Case Study
Authors: Zhang Zhonghao , Xiao Rui , Shortridge Ashton , Wu Jiaping
Published: March 2014

Understanding the spatial point pattern of human settlements and their geographical associations are important for understanding the drivers of land use and land cover change and the relationship between environmental and ecological processes on one hand and cultures and lifestyles on the other. In this study, a Geographic Information System (GIS) approach, Ripley’s K function and Monte Carlo simulation were used to investigate human settlement point patterns. Remotely sensed tools and regression models were employed to identify the effects of geographical determinants on settlement locations in the Wen-Tai region of eastern coastal China. Results indicated that human settlements displayed regular-random-cluster patterns from small to big scale. Most settlements located on the coastal plain presented either regular or random patterns, while those in hilly areas exhibited a clustered pattern. Moreover, clustered settlements were preferentially located at higher elevations with steeper slopes and south facing aspects than random or regular settlements. Regression showed that influences of topographic factors (elevation, slope and aspect) on settlement locations were stronger across hilly regions. This study demonstrated a new approach to analyzing the spatial patterns of human settlements from a wide geographical prospective. We argue that the spatial point patterns of settlements, in addition to the characteristics of human settlements, such as area, density and shape, should be taken into consideration in the future, and land planners and decision makers should pay more attention to city planning and management. Conceptual and methodological bridges linking settlement patterns to regional and site-specific geographical characteristics will be a key to human settlement studies and planning.
Metallocene Based Polyolefin Nanocomposites
Authors: Kaminsky Walter
Published: March 2014

One of the most efficient and versatile ways to synthesize polyolefin nanocomposites is the in-situ polymerization of olefins in the presence of nano particles by metallocene catalysts. Metallocene/methylaluminoxane (MAO) catalysts are soluble in hydrocarbons and therefore they can be absorbed perfectly in solution onto the surface of particles or fibers and after addition of ethene or propene they can then catalyze a polyolefin film on the surface. Metallocene/MAO and other single site catalysts allow the synthesis of polymers with a precisely defined microstructure, tacticity, and stereoregularity as well as new copolymers with superior properties such as film clarity, high tensile strength and lower content of extractables. The polymer properties can be enlarged by the incorporation of nanofillers. The resulting polyethylene or polypropylene nanocomposites give a tremendous boost to the physical and chemical properties such as dramatically improved stiffness, high gas barrier properties, significant flame retardancy, and high crystallization rates.
Assessment of Circulating microRNAs in Plasma of Lung Cancer Patients
Authors: Fortunato Orazio , Boeri Mattia , Verri Carla , Conte Davide , Mensah Mavis , Suatoni Paola , Pastorino Ugo , Sozzi Gabriella
Published: March 2014

Lung cancer is the most common cause of cancer deaths worldwide and numerous ongoing research efforts are directed to identify new strategies for its early detection. The development of non-invasive blood-based biomarkers for cancer detection in its preclinical phases is crucial to improve the outcome of this deadly disease. MicroRNAs (miRNAs) are a new promising class of circulating biomarkers for cancer detection and prognosis definition, but lack of consensus on data normalization methods for circulating miRNAs and the critical issue of haemolysis, has affected the identification of circulating miRNAs with diagnostic potential. We describe here an interesting approach for profiling circulating miRNAs in plasma samples based on the evaluation of reciprocal miRNA levels measured by quantitative Real-Time PCR. By monitoring changes of plasma miRNA-ratios, it is possible to assess the deregulation of tumor-related miRNAs and identify signatures with diagnostic and prognostic value. In addition, to avoid bias due to the release of miRNAs from blood cells, a miRNA-ratios signature distinguishing haemolyzed samples was identified. The method described was validated in plasma samples of lung cancer patients, but given its reproducibility and reliability, could be potentially applied for the identification of diagnostic circulating miRNAs in other diseases.
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
Authors: Santoro Domenico , Gagliostro Giorgia , Alibrandi Angela , Ientile Riccardo , Bellinghieri Guido , Savica Vincenzo , Buemi Michele , Caccamo Daniela
Published: March 2014

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.
Dietary, Lifestyle and Socio-Economic Correlates of Overweight, Obesity and Central Adiposity in Lebanese Children and Adolescents
Authors: Nasreddine Lara , Naja Farah , Akl Christelle , Chamieh Marie , Karam Sabine , Sibai Abla-Mehio , Hwalla Nahla
Published: March 2014

The Eastern Mediterranean region is characterized by one of the highest burdens of paediatric obesity worldwide. This study aims at examining dietary, lifestyle, and socio-economic correlates of overweight, obesity, and abdominal adiposity amongst children and adolescents in Lebanon, a country of the Eastern Mediterranean basin. A nationally representative cross-sectional survey was conducted on 6–19-year-old subjects (n = 868). Socio-demographic, lifestyle, dietary, and anthropometric data (weight, height, waist circumference) were collected. Overweight and obesity were defined based on BMI z-scores. Elevated waist circumference (WC) and elevated waist to height ratio (WHtR) were used as indices of abdominal obesity. Of the study sample, 34.8% were overweight, 13.2% were obese, 14.0% had elevated WC, and 21.3% had elevated WHtR. Multivariate logistic regression analyses showed that male gender, maternal employment, residence in the capital Beirut, sedentarity, and higher consumption of fast food and sugar sweetened beverages were associated with increased risk of obesity, overweight, and abdominal adiposity, while regular breakfast consumption, higher intakes of milk/dairies and added fats/oils were amongst the factors associated with decreased risk. The study’s findings call for culture-specific intervention strategies for the promotion of physical activity, healthy lifestyle, and dietary practices amongst Lebanese children and adolescents.
Flexural Behavior of RC Members Using Externally Bonded Aluminum-Glass Fiber Composite Beams
Authors: Hong Ki-Nam , Cho Chang-Geun , Lee Swoo-Heon , Park Yeonho
Published: March 2014

This study concerns improvement of flexural stiffness/strength of concrete members reinforced with externally bonded, aluminum-glass fiber composite (AGC) beams. An experimental program, consisting of seven reinforced concrete slabs and seven reinforced concrete beams strengthened in flexure with AGC beams, was initiated under four-point bending in order to evaluate three parameters: the cross-sectional shape of the AGC beam, the glass fiber fabric array, and the installation of fasteners. The load-deflection response, strain distribution along the longitudinal axis of the beam, and associated failure modes of the tested specimens were recorded. It was observed that the AGC beam led to an increase of the initial cracking load, yielding load of the tension steels and peak load. On the other hand, the ductility of some specimens strengthened was reduced by more than 50%. The A-type AGC beam was more efficient in slab specimens than in beam specimens and the B-type was more suitable for beam specimens than for slabs.
A Synergetic Algorithm for Mid-Morning Land Surface Soil and Vegetation Temperatures Estimation Using MSG-SEVIRI Products and TERRA-MODIS Products
Authors: Zhao Wei , Li Ainong , Bian Jinhu , Jin Huaan , Zhang Zhengjian
Published: March 2014

Land surface is normally considered as a mixture of soil and vegetation. Many applications, such as drought monitoring and crop-yield estimation, benefit from accurate retrieval of both soil and vegetation temperatures through satellite observation. A preliminary study has been conducted in this study on the estimation of land surface soil and vegetation component temperature using the geostationary satellite data acquired by Spinning Enhanced Visible and Infrared Imager (SEVIRI) onboard the Meteosat Second Generation (MSG) and TERRA-MODIS data. A synergetic algorithm is proposed to derive soil and vegetation temperatures by using the temporal and spatial information in SEVIRI and MODIS products. The approach is applied to both simulation data and satellite data. For simulation data, the component temperatures are well estimated with root mean squared error (RMSE) close to 0 K. For satellite data application, reasonable spatial distributions of the soil and vegetation temperatures are derived for eight cloud-free days in the Iberian Peninsula from June to August 2009. An evaluation is performed for the estimated vegetation temperature against the near surface air temperature. The correlation analysis between two datasets is found that the R-squareds are from 0.074 to 0.423 and RMSEs are within 4 K. Considering the impact of fraction of vegetation cover (FVC) on the validation, the pixels with FVC less than 30% are excluded in the total data comparison, and an obvious improvement is achieved with R-squared from 0.231 to 0.417 and RMSE from 2.9 K to 2.58 K. The validation indicates that the proposed algorithm is able to provide reasonable estimations of soil and vegetation temperatures. It is a potential way to map soil and vegetation temperature for large areas.
Recent Advances in Gas and Chemical Detection by Vernier Effect-Based Photonic Sensors
Authors: La Notte Mario , Troia Benedetto , Muciaccia Tommaso , Campanella Carlo , De Leonardis Francesco , Passaro Vittorio
Published: March 2014

Recently, the Vernier effect has been proved to be very efficient for significantly improving the sensitivity and the limit of detection (LOD) of chemical, biochemical and gas photonic sensors. In this paper a review of compact and efficient photonic sensors based on the Vernier effect is presented. The most relevant results of several theoretical and experimental works are reported, and the theoretical model of the typical Vernier effect-based sensor is discussed as well. In particular, sensitivity up to 460 μm/RIU has been experimentally reported, while ultra-high sensitivity of 2,500 μm/RIU and ultra-low LOD of 8.79 × 10−8 RIU have been theoretically demonstrated, employing a Mach-Zehnder Interferometer (MZI) as sensing device instead of an add drop ring resonator.
AN APPROXIMATE METHOD FOR THE ULTIMATE SHEAR STRENGTH OF HORIZONTALLY CURVED COMPOSITE PLATE GIRDERS
Authors: Shanmugam Nandivaram E. , Basher Mohammed A. , Rashid Khalim A.
Published: March 2014

The paper is concerned with the ultimate load capacity of horizontally curved composite plate girders. An approximate method to predict the ultimate shear strength of the girders is presented. The proposed method accounts for the tension field action in web panels, composite action between steel plate girder and reinforced concrete slab with full interaction and presence of web openings. The accuracy of the method is assessed by comparing the predicted values of ultimate shear strength with the corresponding results obtained by using the nonlinear finite element analyses through a computer package LUSAS. The comparisons show that the proposed method is capable of predicting the ultimate shear strength with an acceptable accuracy. Presence of web openings of different proportions and their effects on ultimate strength of the girders are examined. Girders with trapezoidally corrugated webs are also considered in the study.
VERTICAL CAPACITY OF BUCKET FOUNDATIONS IN UNDRAINED SOIL
Authors: Barari Amin , Ibsen Lars Bo
Published: March 2014

Offshore wind turbine structures are traditionally founded on gravity concrete foundations or mono-piles. Bucket foundations were developed for the offshore oil and gas industry and are now being used in wind turbine construction. The loading in this application is characterized by a vertical load due to the slender construction combined with horizontal forces inducing a large overturning moment. Field tests on bucket foundations were performed to gain insight into the vertical load response of bucket foundations in clay soils. The field tests were accompanied by finite element numerical simulations in order to provide a better understanding of the parameters influencing bucket foundation behaviour.
APPLICATION OF IMPORTANCE-SATISFACTION ANALYSIS AND INFLUENCE-RELATIONS MAP TO EVALUATE DESIGN DELAY FACTORS
Authors: Wang Wei-Chih , Lin Chia-Li , Wang Shih-Hsu , Liu Jang-Jeng , Lee Ming-Tsung
Published: March 2014

Design delays can negatively influence the total completion time of a facility construction project. Knowing the factors to which design delays are most sensitive supports the time management of designs. However, factors that cause design delays are several and interrelated. This study proposes a new model to identify key factors that drive design delays. The core of the model integrates importance-satisfaction analysis (ISA) and an influence-relations map (IRM). The ISA evaluates the performance of each delay factor, while the IRM captures the causal relationships among factors. Additionally, the IRM is generated using a decision making trial and evaluation laboratory technique (DEMATEL). The model is applied to a real-world high-tech facility construction project to indicate the strengths of the model. In this investigation, four first-level delay factors and 17 second-level delay sub-factors are derived. The factor of “organization's decision making and budget constraints” is identified as the key driver of design delays in the project of interest. The results support management in determining which problem factors should be given priority attention. The proposed model can be employed in other decision-making situations that involve interrelated factors.
ENHANCING THE DURABILITY OF CONCRETE MADE OF CONCRETE RECYCLATE BY ADDITIVES AND ADMIXTURES
Authors: Stehlík Michal
Published: March 2014

The aim of this research is to find an optimum combination of silicate admixtures and epoxy dispersion additives which would positively influence the durability and mechanical properties of concretes made of concrete recyclate. The durability of concrete is dependent on its cover layer permeability and also on the overall permeability of concrete recyclate. The cover layer permeability was evaluated by means of three methods, namely the air permeability method TPT and two methods of measuring water permeability, GWT and ISAT. Fine silicate admixtures and dispersion additives influence the air and water permeability of concrete made of concrete recyclate in different ways. The dose of 10% of microsilica or 30% of slag or fly ash decreases the air permeability of concrete. Water permeability, on the other hand, is decreased by adding a dose of 12% of pure epoxy dispersion. As regards improving the mechanical properties of concrete made of concrete recyclate, it seems to be promising to use a combination of 30% of slag admixture or 10% of microsilica admixture with 12% of epoxy dispersion additive. However, the price of admixtures and additives is relatively high. That is why additive enhanced concretes made of concrete recyclate are intended for special purposes.
EXPERIMENTAL STUDY ON INFLUENCE OF STACK EFFECT ON FIRE IN THE COMPARTMENT ADJACENT TO STAIRWELL OF HIGH RISE BUILDING
Authors: Shi Wen Xi , Ji Jie , Sun Jin Hua , Lo S. M. , Li Lin Jie , Yuan Xiang Yong
Published: March 2014

In this paper, to study the influence of stack effect on fire in the compartment adjacent to a stairwell, a set of experiments were conducted by varying the pool size, top vent state and bottom vent size in a 1/3 scaled 12-layer-stairwell configuration. The phenomenon of methanol flame tilting in the fire room was observed and studied. Results showed that the flame tilt angle increases with an increase of Ri-1. The temperatures of hot gases in the fire room decrease due to the cooling effect of fresh air induced by stack effect. The mass loss rate of methanol fuel is influenced by fresh air flow sucked into fire room due to stack effect. On the basis of the experimental results, we conclude that the velocity of air flow into fire room is proportional to 1/3 power of the heat release rate in the stairwell.
EFQM EXCELLENCE MODEL AS THE TQM MODEL OF THE CONSTRUCTION INDUSTRY OF SOUTHEASTERN EUROPE
Authors: Vukomanovic Mladen , Radujkovic Mladen , Nahod Maja Marija
Published: March 2014

Over the years the European Foundation for Quality Management Excellence model (EFQM) has become a popular performance management tool and representation of Total Quality Management (TQM) in Europe. Although the model has been tested and supported by many questionnaire surveys, EFQM has never been validated on real self-assessment scores obtained from companies. Therefore this study validates the model on scores from 34 construction companies in South Eastern Europe. The analysis shows that: a) there is an enabler excellence construct that is obtained by each enabler criteria; b) there is a result excellence construct that is obtained by each result criteria; and c) the EFQM model is most suitable for Contractor type organizations. Furthermore, we have found that the EFQM weights do not entirely correspond with the construction industry. Therefore we present new weights for the better use in the construction. Although this study proves EFQM to be a good representation of TQM in the construction industry, further improvements are needed. This is especially evident within investor and consultant type organization, where the criteria of Policy and Strategy, Leadership and Processes, People results and Client results showed certain limitations.
On the Moral Equality of Artificial Agents
Authors: Wareham Christopher
Published: March 2014

Artificial agents such as robots are performing increasingly significant ethical roles in society. As a result, there is a growing literature regarding their moral status with many suggesting it is justified to regard manufactured entities as having intrinsic moral worth. However, the question of whether artificial agents could have the high degree of moral status that is attributed to human persons has largely been neglected. To address this question, the author developed a respect-based account of the ethical criteria for the moral status of persons. From this account, the paper employs an empirical test that must be passed in order for artificial agents to be considered alongside persons as having the corresponding rights and duties.
Re-Visiting Democratic Pedagogy in the Context of Virtual Learning Communities
Authors: Oztürk Hayriye Tugba
Published: March 2014

The purpose of this research is two-fold. First, it provides an overview of the debates over whether technology facilitates democratic education. Second, from this emergent body of discussions in the literature, it critically examines the potential of a virtual learning community to materialise democratic education, both through its underpinning of ideal values such as autonomy, participation and mutuality and through the technological spaces which learners inhabit. Virtual learning communities (VLCs) are increasingly appearing in the field of open education and in that sense, these emerging virtual communities demand a new understanding of democratic pedagogy. With regard to this, drawing on the theoretical debates, it aims to discuss how technology can take place in re-exploring the democratic pedagogy under the scope of VLCs. In doing this, a critical in-depth literature review was undertaken in an emergent area of virtual communities by aiming to contribute to the discussions over conceptualizing the democratic VLCs.
Etiese perspektiewe op haatspraak in die lig van die derde gebod
Authors: Vorster Jakobus M.
Published: March 2014

Hierdie artikel fokus op die implikasies van die derde gebod met betrekking tot haatspraak in Suid-Afrika (SA) vandag. Die artikel gaan uit van die standpunt dat die name van God op sy wese dui. Die name van God soos dit in die bybelse openbaringsgeskiedenis ontwikkel word, druk die gemeenskapskarakter van God se verhouding met mense en die skepping uit. Die betekenis van die name kulmineer in die Nuwe-Testamentiese uitdrukkings Vader en God is liefde. Alle verbale gedrag wat hierdie gemeenskaps- en liefdesverhouding inhibeer, oortree die derde gebod. Die misbruik van die Naam van God vind onder andere plaas wanneer mense, wat na die beeld van God geskep is, gedegradeer word deur haatspraak, omdat sodanige degradering die gemeenskap en liefde tussen God en die mens skend. Ten slotte word sekere gevalle van haatspraak soos dit vandag in Suid-Afrika voorkom, teologies-eties belig teen die agtergrond van die betekenis van die derde gebod. Hierdie vorms sluit religieuse, rassistiese, xenofobiese, seksistiese en homofobiese haatspraak in.This article focuses on the implications of the third commandment for hate speech in modern-day South Africa. The article contends that the names of God are expressions of his Being. The names of God as they are developed in the biblical history of revelation express his creation of covenantal community and restored relations with humankind and creation. The meaning of the names of God culminates in the New Testament expressions Father and God is love. Verbal actions that inhibit the new community created by God or violate love transgress the third commandment. Misuse of the name of God occurs among others when people, created in the image of God, are verbally degraded by hate speech because such degradation violates the community of love between God and humankind. In conclusion, the article indicates forms of hate speech in South Africa that should be dealt with in the light of the third commandment. These are acts of racist, xenophobic, sexist, religious and homophobic hate speech.