bluuebunny/crossref_metadata_2025 huggingface dataset:
Soil Legacy Phosphorus Transformation in Long-term Fertilized Phaeozems Soil under Maize/Soybean Intercropping
Authors: Li Yang , Zhao Yuhang , Chen Tianwen , Zhou Junfeng , Ma Hanying , Chen Yuanquan , Sui Peng
Published: February 2024

Root exudate could improve crop productivity and phosphorus (P) acquisition in maize/soybean intercrops. However, the synergistic effects between intercropped plants, the regulation of soil phosphatase activity, and P transformation corresponding to it remain elusive. Three kinds of root separation treatments, solid barrier (SB), mesh barrier (MB), and no barrier (NB), using pot experiment, were conducted to quantify the effects of plants, rhizosphere exudates exchange and the complete root interaction. Sequential extraction and 31P-NMR spectroscopic analysis methods complement each other, which can better explain the combination forms of P elements. This work suggests that maize under NB stimulated a decrease in NH4F-inorganic P (Pi, 7.91%) and occluded Pi (7.46%) compared to those under SB. In the presence of maize signaling chemicals (MB treatment), the percentage of mononucleotides was enriched, while neo-inositol hexakisphosphate, β-glycerophosphate, and phosphocholine declined in the soybean rhizosphere compared to SB. Under both two plants, phosphodiesterase (PDE) activity was negatively correlated with pyrophosphate. The activity of alkaline phosphatase (ALP) was the highest in the MB treatment of maize and soybean, which increased from 33.80 to 44.5 and 41.92 (ug g− 1 h− 1) compared with bulk soil. Maize under monocropping mainly mobilizes acid phosphatase (ACP), but it is converted to ALP and PDE when intercropping with soybean. Knowledge of P species in P-rich soils helps assess P potential transfer and provides new evidence for the value of cereal-legume intercrops in reducing fertilizer input.
Ambient Air Quality Monitoring of Sankari Crystalline Mining Areas in Salem District Tamil Nadu India
Authors: Sakthivel Chinnadurai , Thirunavukkarasu Arisiappan
Published: February 2024

To access the Ambient Air Quality monitoring of Sankari crystalline Limestone Mining areas in Salem District of Tamil Nadu, India, this study was conducted during the year 2018 to 2019. A total of ten (10) locations were selected in the study area for ambient air quality monitoring for five pollutants mainly particulate Matter less than 10 µ sizes (PM10), Particulate Matter less than 2.5 µ size (PM2.5), Nitrogen dioxide (NO2), sulfur dioxide (SO2) and Ozone (O3). The study revealed that the average concentration of gaseous pollutants i.e. NO2, SO2, and O3 in ambient air are well within standard limits at all selected locations however particulate matter (PM10, PM2.5) levels were found to exceed national Ambient Air Quality Standards 2009 at all monitoring locations. The Air Quality Index was poor (Alathur-209.56 and Karumapurathanur-203.39) at two locations, moderate (Virachipalayam-198.12, Pallakkapalayam-137.46, Chinnagundanur-165.45, Devannagoundanur − 174.24, Sanniyasipatti 142. 61, Arasiramani 184.41) at six locations and satisfactory (Padaiveedu-95.02, Sankari − 68.37) at two locations in the Sankari areas. Overall ambient Air Quality monitoring of Sankari areas was observed to be moderate during this study span.
An analytic derivation of the galaxy halo density profile
Authors: Booth Robin Anthony James
Published: February 2024

We examine some of the consequences of the exochronous (timeless) metric and the associated $\Sigma$GR cosmological model for the formation of galaxies, and in particular, their characteristic rotation curves. We show how the cumulative curvature from the multiple spatial hypersurfaces in this model leads to a modified version of the Poisson equation in which the gravitational potential is computed over 4D space.Using this new form of the Poisson equation, we derive an analytic expression for gravitational potential as a function of radial distance for a uniform gas cloud undergoing gravitational collapse. We show that this results in a radial velocity profile that provides an excellent fit with commonly observed galaxy rotation curves, and hence fully accounts for the effects previously ascribed to dark matter. An expression can be derived for the equivalent matter density profile corresponding to the $\Sigma$GR gravitational potential, from which it is evident that this is very similar in form to the well known Navarro-Frenk-White profile.
As a further illustration of the consequences of adopting the exochronous metric, we show how the principle can readily be incorporated into particle-mesh N-body simulations of large scale structure evolution, using a relaxation solver for the solution to the Poisson equation and the evolution of the gravitational potential. Examples of the use of this simulation model are shown for the cases of: (a) initial evolution of large scale structure, and (b) galaxy formation from a gravitationally collapsing gas cloud. In both cases is is possible to directly visualise the build up of the gravitational potential in 3D space as the simulation evolves, and note how this corresponds to what is currently assumed to be dark matter.
Ten Years after the Implementation of the Risk Management Plan in Japan: The Impact of Risk Management Plan on Package Insert Revision
Authors: Kameyama Natsuko , Hosaka Aoi , Maeda Hideki
Published: February 2024

It has been 10 years since the Japanese Risk Management Plan (RMP) was implemented in 2013. However, the impact of the Japanese RMP (J-RMP) system on drug safety measures is unclear. Herein, we investigated the impact of the J-RMP system on package insert (PI) revision, focusing on the rapidity of identification of clinically significant adverse reactions (ARs) as an effect indicator of the J-RMP system in drug safety measures. We created an original database from public information of the Pharmaceuticals and Medical Devices Agency and investigated the speed of adding clinically significant ARs to PIs. Comparing the time lapse from drug approvals to PI revisions after the implementation of the J-RMP system to that before implementation, the median value was 32 months vs. 32 months (149 vs. 318 cases), and no significant difference was observed. We also compared the time lapse from drug approvals to PI revisions when additional ARs had been included as safety specifications at the time of drug approvals and when they had not been included, and the median value was 35 months vs. 32 months (14 cases vs. 126 cases, p = 0.7820), and no statistically significant difference was observed. Therefore, it was suggested that the J-RMP system did not affect PI revision and its speed. It should be considered how to effectively utilize J-RMP for safety measures in Japan.
Is there some predictive factors for isolated brain PROgression in patients with CErebral metastatic MElanoma after treatment with stereotactic brain radiotherapy ? a retrospective, single-center study. PROCEME
Authors: CROIX Manuel , LEQUESNE Justine , GEFFRELOT Julien , DOMPMARTIN Anne , L’ORPHELIN Jean Matthieu
Published: February 2024

Purpose Melanoma is a skin cancer with an excellent prognosis if diagnosed at an early stage. Melanoma has a high potential for brain metastasis, making the prognosis considerably poorer despite the development of local and systemic treatments. In current practice, we observe discordant responses and progression profiles at cerebral and extra-cerebral levels. The aim of this study was to identify predictive factors of isolated brain progression after treatment with stereotactic brain radiotherapy, with or without systemic treatment.Methods Between January 2014 and December 2020, 121 patients treated with stereotactic brain radiotherapy in context of melanoma stage IV were included. Radiotherapy was associated to systemic treatment in the major of cases (Targeted Therapies, Immunotherapy, or Chemotherapy).Results In our cohort, 83 patients showed progression after stereotactic brain radiotherapy: 38 in brain only, 45 in brain and at distance. The study showed a double increase in the risk of isolated brain progression in BRAF V600 mutated patients compared with BRAF V600 WT patients (OR = 2.29; CI 95 [0.94; 5.72] p-value 0.071), but not confirmed after adjustment on confounding factors. BRAF V600 WT patients treated with immunotherapy have a 4-fold greater risk of multi-site progression, compared to BRAF V600 mutated treated with targeted therapies (OR: 0.233 IC95% [0.58 ;0.847]).Conclusion BRAF V600 mutated melanomas seems more at risk of isolated brain escape in our cohort we therefore need to develop new local therapies for these patients in the future, and clarify the mechanisms of intrinsic and extrinsic resistance.
Benchmarking the use of Dimensional Reduction Techniques: A Case Study of Oesophageal Cancer Image Analysis
Authors: Nath Shekhar Jyoti , Panda Satish K. , Kar Rajiv K.
Published: February 2024

The dimensionality reduction method is one of the most popular approaches for handling complex data characterised by numerous features and variables. In this work, we benchmarked the application of different techniques to interpret cancer-based in vivo microscopic images. We focus on several dimensionality reduction methods, including PCA, LDA, t-SNE, and UMAP, to evaluate the performance of the image dataset analysis (5043 images). The benchmarking study establishes the efficacy of traditional machine learning algorithms for biomedical image analysis. Model descriptions based on logistic regression, support vector, K-means clustering, K-nearest neighbour, random forest, gradient boosting, and adaboost classifiers were employed. The study also evaluates the importance of visualisation techniques relevant for identifying hidden patterns, anomalies, and trends that are not readily discernible in high-dimensional data. The benchmarking study uses approaches like random splits and K-fold cross-validation. Further evaluation metrics such as accuracy, sensitivity, specificity, and ROC-AUC score are employed to assess the performance of the employed dimensionality reduction methods. Their relevance for data visualisation as well as predictive modelling is demonstrated. Overall, the study is useful for understanding the relevance of effective data classification and visualisation problems, thereby enhancing the interpretability and analysis of biomedical images.
Effect of Solid Waste Generation on Soil Quality Dynamics
Authors: Udoh Ubong Godswill
Published: February 2024

The consequences of solid waste on soil quality were carried out by collecting Soil samples taken in triplicate from different soil layers (0-15cm, 15-30cm, and 30-45cm) and analyzed to determine the effect of solid waste on the physical and chemical parameters of the soil surrounding the research area, to ascertain the level of heavy metals in the soil and to compare values with the National Environmental Standards and Regulation Enforcement Agency and the World Health Organization recommended standards. The elemental composition of selected heavy metals from the dumpsite was done using an atomic absorption spectrophotometer. The mean values of soil pH ranged from 5.50–4.72 in the dumpsite and 7.51–6.99 in the control site in all three soil depths (0–15, 15–30, 30-45em) this indicates that the soil at the dump site was moderately acidic at 5.50 (0-15cm soil depth) and very strongly acidic at 4.72 (30-45cm soil depth), while that of the control was almost neutral at 6.77 (0–15 soil depth) and slightly alkaline at 7.51 (30–45 soil depth). The organic matter level of the soil varied significantly (P = 0.05), with the topsoil (0-15cm) having the highest concentration. The topsoil organic matter at the dumpsite soil was 14.72%, compared to 17.55% at the control site. This study found that the concentration of heavy metals such as cadmium, cobalt, copper, lead, manganese, nickel, and zinc in the dumpsite was substantially greater (p 0.05) than in the control site.
The potential of SCUBE-1 levels as a biomarker for placental malfunction in preeclampsia
Authors: ALTINCI Halil İbrahim , YÜCEL Neşe , ADIGÜZEL Fikriye Işıl , KÜKRER Sadık
Published: February 2024

Purpose
The aim of the study is to compare the plasma levels of SCUBE-1, a marker of vascular injury and endothelial dysfunction, between preeclamptic and normotensive pregnant women.
Methods
The current study was carried out at Health Sciences University Adana City Training and Research Hospital, implementing a prospective research design. The study included 46 pregnancies diagnosed with preeclampsia and an equal number of pregnancies with normal blood pressure, serving as control subjects.
Results
There were no statistically significant differences observed in age, gravidity, parity, or BMI as demographic features among the groups. A significant increase in the concentrations of SCUBE-1 levels was observed in pregnancies that presented with preeclampsia (p < 0.001).
Conclusions
The potential of SCUBE-1 as a prognostic indicator for vascular damage in pregnancy is worth considering. Our research is the initial investigation to demonstrate elevated levels of SCUBE-1 in preeclampsia, indicating impaired function of the endothelial cells in the placenta.
Fracture Mechanics Modeling of Aortic Dissection
Authors: Yeerella Ram Hemanth , Cai Shengqiang
Published: February 2024

Aortic dissection, a critical cardiovascular condition with life-threatening implications, is distinguished by the development of a tear and its propagation within the aortic wall. A comprehensive comprehension of the initiation and progression of these tears, or cracks, is essential for accurate diagnosis and effective treatment. This paper undertakes a fracture mechanics approach to delve into the mechanics of tear propagation in aortic dissection. Our objective is to elucidate the impact of geometric and material parameters, providing valuable insights into the determinants of this pivotal cardiovascular event. Through our investigation, we have gained an understanding of how various parameters influence the energy release rate for tear propagation in both longitudinal and circumferential directions, aligning our findings with clinical data.
Features of germination, emergence modeling, longevity, and persistence in Bidens pilosa seed bank
Authors: Zandoná Renan Ricardo , Goulart Francisco de Assis Pujol , Puntel Simone , Ulguim André Da Rosa , Agostinetto Dirceu
Published: February 2024

To develop models capable of predicting the emergence of hairy beggarticks and assist integrated management, it is fundamental to have knowledge of the environmental factors that influence the germination of the species. The objective of this study was to estimate temperature and water potential cardinals for hairy beggarticks germination, the longevity of its seed bank, and to develop a model of its emergence in the field. Experiments were carried out in the laboratory to determine the temperature and water potential base for seed germination. Eight different temperatures (10.0, 15.0, 20.0, 25.0, 30.0, 35.0, 40.0, and 45.0°C), and 10 different water potentials (0, -0.05, -0.1, -0.2, -0.4, -0.6, -0.9, -1.2, -1.5, and − 2.0 MPa) were tested. The field experiments were conducted between 2014 and 2019 using three monitoring seedling emergences. To evaluate the longevity and persistence of the seed bank, a factorial experiment was conducted with three burial depths (0, 3, and 6 cm) and five seed retrieval moments (0, 1, 4, 10, and 16 months). Base, optimal, and maximum temperatures for hairy beggarticks germination are 10.4°C, 24.7°C, and 41.8°C, respectively. The base water potential for the emergence of hairy beggarticks is -0.85 MPa. The thermal and hydrothermal time models are adequate to predict the emergence of hairy beggarticks in different soybean sowing dates. The species has a transient seed bank, however, the greater the seed burial depth, the greater the longevity of the soil seed bank.
AI in Education: A Cross-National Study of Open Schooling Using the CARE-KNOW-DO Framework for Sustainable Development Goals.
Authors: Okada Alexandra , Sherborne Tony , Panselinas Giorgos , Kolionis Georgios
Published: February 2024

This cross-national mixed-methods study examines transversal skills views of 330 underserved secondary school students from the UK, Greece, and Brazil. This work validates a new self-reported instrument with AI-based open schooling activities within the CARE-KNOW-DO framework. This study combines quantitative and qualitative analyses to evaluate pedagogical strategies' effectiveness in nurturing vital 21st-century skills. The findings highlight seven key components: proactive exploration, problem solving, scientific citizenship, science connection, affective engagement, science participation, and future prospects. This study emphasizes the importance of customized educational approaches to suit cultural and age differences, promoting flexible curricula and innovative teaching methods. This research aligns with Agenda 2030, aiming to enhance global educational strategies through open schooling initiatives for sustainable and inclusive education.
Fast Complete Algorithm for Multiplayer Nash Equilibrium
Authors: Ganzfried Sam
Published: February 2024

We describe a new complete algorithm for computing Nash equilibrium in multiplayer general-sum games, based on a quadratically-constrained feasibility program formulation. We demonstrate that the algorithm runs significantly faster than the prior fastest complete algorithm on several game classes previously studied and that its runtimes even outperform the best incomplete algorithms.
A rapid LAMP assay for the diagnosis of oak wilt with the naked eye
Authors: Novi Vinni Thekkudan , Aboubakr Hamada A. , Moore Melanie J. , Juzwik Jennifer , Abbas Abdennour
Published: February 2024

Background
Oak wilt disease, caused by Bretziella fagacearum is a significant threat to oak (Quercus spp.) tree health in the United States and eastern Canada. Without management the disease may cause dramatic changes to natural and urban ecosystems. Early and accurate diagnosis followed by timely treatment increases the level of disease control success.
Results
A rapid assay based on loop mediated isothermal amplification (LAMP) was first developed with fluorescence detection of the target fungus after 30-minute reaction time. Six different primers were designed to specifically bind and amplify the pathogen’s DNA. To simplify the assay for “point of care” (i.e., field) use, gold nanoparticles (AuNPs) were designed to bind to the amplified DNA (amplicon) obtained from the LAMP reaction. Upon inducing precipitation, the AuNP-amplicons settle as a red pellet visible to the naked eye, indicative of pathogen presence. Both infected and healthy red oak samples were tested using this visualization method. The sensitivity and specificity of the assay were calculated to be 100%. Moreover, the developed assay was able to detect the pathogen in crude DNA extracts of diseased oak wood samples, which further reduced the time required to process samples.
Conclusions
In summary, the LAMP assay coupled with oligonucleotide-conjugated gold nanoparticle visualization is a promising method for accurate and rapid molecular-based diagnosis in field settings. The new method can be adapted to other forest and plant diseases by simply designing new primers.
Developmental odontogenic cysts with special focus on the occurrence of multiple cysts: a single-centre retrospective study from the Czech Republic
Authors: Szaraz David , Ksinan Albert J. , Machacek Ctirad , Linhartova Petra Borilova
Published: February 2024

Background
This retrospective study aims to evaluate the relative representation of individual types of developmental odontogenic cysts (DOCs), especially from the perspective of syndromic and non-syndromic multiple DOCs in the Czech population. In addition, we also summarize the previous studies on the occurrence of multiple DOCs as well as provide a literature review of case reports and case series on non-syndromic multiple DOCs, mainly dentigerous cysts and odontogenic keratocysts.
Methods
The study included histologicaly confirmed DOCs retrieved between January 1, 2012, and August 8, 2023, at the Clinic of Maxillofacial Surgery, University Hospital Brno, Czech Republic. All specimens were re-classified according to the fifth edition of the World Health Organization Classification of Head and Neck Tumors, 2022. Patients with an uncertain histological diagnosis were excluded from the study.
Results
Of a total of 377 patients, 286 had dentigerous cysts (DCs), 85 odontogenic keratocysts (OKCs), 5 orthokeratinizing odontogenic cysts (OOCs), 1 botryoid cyst and 1 calcifying odontogenic cyst. 19 multiple cysts were observed in the DC group, all without any association with a syndrome. Among the OKCs, 6 patients were diagnosed with the Naevoid Basal Cell Carcinoma Syndrome (NBCCS) and 3 were non-syndromic. Recurrence of OKCs was associated with NBCCS (p < 0.05). OKCs appeared more frequently in younger patients and predominantly in women, while the opposite was observed in DCs (p < 0.05 for all). Both these lesions affected the mandible in the vast majority of cases. Only one patient presented with bilateral OOCs, without any association with a syndrome.
Conclusion
Multiple OKCs are more likely to develop in syndromic patients, while none of the multiple DCs were associated with a syndrome. The incidence of multiple OOCs and other DOCs is extremely rare.
Delineation of Groundwater Potential and the Susceptibility to Surface Contaminants
Authors: Ango Abubakar , Emmanuel Jaiyeoba , Ekwu Mary T
Published: February 2024

Groundwater remains an essential natural resource that is found in every part of the Earth’s subsurface. However, the high level of borehole failures due to inadequate subsurface information about the regional hydrogeological nature has led to significant water scarcity in both rural and semi-urban regions. This study applies the vertical electrical sounding method to delineate regional aquifer potential alongside the vulnerability to the agrochemical activities in a rapidly emerging agricultural development at Kujama Farmland for groundwater development. Information obtained was used to construct the soil depth section and the groundwater potential as well as its protective capacity. The depth section shows that the study area is underlain by four distinctive geo-electric layers. The weathered/fractured unit was delineated as the water-bearing unit of the study area for groundwater development. The aquifer parameters such as resistivity and depth values vary between 21 Ωm – 328 Ωm and 19 m – 42 m, respectively. However, the observed thick aquifer with low resistivity values was considered as the region of the rich aquifer and it could supply sustainable water for drinking, domestic use and irrigation. Consequently, the siting of industrial/public/domestic boreholes should sunk to at least a depth of 30/20/10m respectively. On the other hand, the computed aquifer parameters show that the study is considered 75% highly protective, 22% moderately protective and 2% weakly protective from the possible surface contaminants emanating from the emerging agricultural activities at Kujama Multipurpose Farmland.
Phosphorus Fertilization Can Improve Young Almond Tree Growth in Multiple Replant Settings
Authors: Gordon Phoebe E. , Ott Natalia J. , Brar Raman K. , Holtz Brent A. , Browne Greg T.
Published: February 2024

Young almond (Prunus amygdalus) orchards replanted where old orchards of stone fruits (Prunus sp.) have been removed are subject to physical, chemical, and biotic stressors. Among biotic challenges, for example, is almond/stone fruit replant disease (ARD; formally known as Prunus replant disease), which specifically suppresses the growth and yields of successive almond and other stone fruit plantings and is caused, in part, by a soil microbial complex. During four orchard trials representing different almond replant practices and scenarios in the San Joaquin Valley in California, we examined the impacts of phosphorus (P) fertilization on the growth of replanted almond. During all trials, P was applied to tree root zones just after replanting, and the impact was assessed according to trunk cross-sectional area (TCSA) growth for 2 years. Expt. 1 was performed where a previous almond orchard was cleared using whole orchard recycling (i.e., the old orchard was “chipped” and then turned into the soil). The land was replanted without preplant soil fumigation. We tested separate fertilizer treatments based on various P, nitrogen, micronutrient, and “complete” formulations. Expt. 2 was also performed where an old almond orchard was recycled, but the soil was preplant-fumigated before replanting. Here, we tested only P fertilization. Expts. 3 and 4 were conducted where an old peach (Prunus persica) orchard was removed. Here, P and nitrogen fertilizer treatments were tested among additional factors, including preplant soil fumigation (Expts. 3, 4) and whole orchard recycling chips (Expt. 4). During all four trials, P fertilization (P at 2.2 to 2.6 oz/tree within a few weeks after planting) significantly increased TCSA growth. The growth benefit was nuanced, however, by almond cultivar, date of replanting, rootstock, and other site-specific factors. Although P fertilization did not match the benefit of preplant soil fumigation for the management of ARD, our data indicated that P fertilization can improve the growth of young almond orchards in diverse replant settings with or without preplant soil fumigation and should be considered by California almond producers as a general best management practice.
Сравнительный анализ эффективности режимов мобилизации аутологичных гемопоэтических стволовых клеток у больных множественной миеломой
Authors: Кострома Иван Иванович , Чубукина Ж. В. , Юдина В. А. , Романенко Н. А. , Степченкова Е. И. , Бессмельцев С. С. , Сидоркевич С. В. , Грицаев С. В.
Published: February 2024

Aim. To compare the efficacy of mobilization regimens (MR) differing in their composition and intensity, with the purpose of defining the criteria to personalize the choice of MR based on clinical and hematological characteristics of multiple myeloma (MM) patients.

Materials & Methods. A retrospective analysis of the autologous hematopoietic stem cell (HSC) mobilization and autograft harvesting results was performed in 177 patients with newly diagnosed MM. The patients were divided into 4 groups. Group 1 included 62 patients with the median age of 53 years who were treated with single injection of cyclophosphamide (CF) dose 3 g/m2 as MR. Group 2 consisted of 71 patients with the median age of 58 years who received vinorelbine 35 mg/m2. Granulocyte colony-stimulating factor (G-CSF) as a monoregimen was administered to group 3 consisting of 33 patients with the median age of 55 years. Group 4 included 11 patients with the median age of 57 years who received G-CSF enhanced by plerixafor administration. G-CSF 10 µg/kg was used as MR. In all chemomobilization cases, daily G-CSF 10 µg/kg started on Day 4 from the administration of the chemotherapy drug prescribed as MR.

Results. In the analyzed groups, the median time from MR start to the first leukocyte apheresis session was 11, 8, 5, and 5 days, respectively. On the first leukocyte apheresis day, the median CD34+ cell collection in group 3 was significantly lower than in groups 1, 2, and 4: 2.2 × 106/kg vs. 3.79 × 106/kg, 7.22 × 106/kg, and 3.9 × 106/kg, respectively. The total CD34+ cell collection after two leukocyte apheresis sessions was also the lowest in group 3 compared with groups 1, 2, and 4: 3.22 × 106/kg vs. 5.2 × 106/kg, 4.95 × 106/kg, and 7.5 × 106/kg, respectively. In the analyzed groups, the rate of mobilization with CD34+ cell collection < 2.0 × 106/kg was 6.5 %, 5.6 %, 18.2 %, and 9.1 %. The evaluation of the results in all patients showed a direct correlation of CD34+ cell collection with lenalidomide administered before autologous HSC mobilization. A significant difference in CD34+ cell collection in lenalidomide recipients vs. non-recipients was reported when vinorelbine as MR and G-CSF as monoregimen (р = 0.001 and р = 0.022, respectively) were used. No significant differences were observed either with CF or G-CSF combined with plerixafor treatment.

Conclusion. Based on the findings, age of a MM patient, comorbidities, and prior lenalidomide administration can be regarded as key criteria for choosing one of 4 MRs.
Медикаментозная защита яичников в период проведения программной противоопухолевой лекарственной терапии у больных с классической лимфомой Ходжкина и неходжкинскими лимфомами
Authors: Антух И. Е. , Шпирко Валерия Олеговна , Назаренко Т. А. , Мартиросян Я. О. , Бирюкова А. М. , Хохлова С. В. , Тумян Г. С.
Published: February 2024

Aim. To assess the efficacy of ovarian protection and options for fertility preservation with the use of gonadotropin-releasing hormone agonists (a-GnRH) in patients with classical Hodgkin lymphoma (cHL) and non-Hodgkin lymphomas (NHLs) during program drug chemotherapy.

Materials & Methods. The study enrolled 247 female patients (187 with cHL and 60 with NHLs) undergoing program drug chemotherapy from 2019 to 2023. The patients were aged 13–42 years (median 24 years). Prior to chemotherapy and after it was completed, the serum anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol levels were measured. Besides, antral follicle count was estimated by pelvic ultrasound. To provide ovarian protection during chemotherapy, a-GnRH was administered to 67 (27 %) out of 247 patients. Ovarian reserve was assessed based on ultrasound and AMH, FSH, and estradiol levels in 2–3 months after completing the program of drug chemotherapy or after spontaneous menstrual recovery.

Results. Menstrual cycle recovered in 194 (78.5 %) out of 247 patients, regardless of lymphoid malignancy variant. Among them, there were 79.7 % (n = 149) of cHL patients and 75 % (n = 45) of NHL patients. Accordingly, ovarian function was lost in 20.3 % (n = 38) of cHL patients and 25 % (n = 15) of NHL patients. Predictors of ovarian function recovery appeared to be age ≤ 28 years and AMH level > 2.45 ng/mL. Pharmacological protection of ovaries did not impact the probability of menstrual cycle recovery. Regardless of immunomorphological variant of lymphoid malignancy, a regular menstrual cycle was completely restored in 48 (71.6 %) out of 67 a-GnRH recipients and in 146 (81.1 %) out of 180 patients without a-GnRH treatment.

Conclusion. Most of cHL and NHL patients of early reproductive age (≤ 30 years) have a fair chance of menstrual cycle recovery after completing the program drug chemotherapy similar to BEACOPP, EACODD(PP)-14, R-CHOP, R-Da-EPOCH and other regimens. Ovarian reserve cannot be preserved by means of a-GnRH administration during chemotherapy. High baseline FSH and low baseline AMH levels indirectly indicate evidence of impaired ovarian reserve. Patients belonging to this category are those who, if intensive combined cytostatic therapy regimens are planned, should undergo prior oocyte/embryo retrieval with subsequent cryopreservation due to the risk of premature loss of ovarian function.
Molybdenum–Vanadium Oxide Clusters: Syntheses, Structures and Antibacterial Properties
Authors: AVCI ÖZBEK Hülya
Published: February 2024

The design and synthesis of polyoxometalates (POMs), a type of inorganic compounds, are of great interest due to their interesting structural properties as well as their extensive theoretical and practical applications in catalysis, electrical conductivity, magnetism, optics and medicine. Therefore, in this study two molybdovanadates [Cu(phen)2]3[Mo6V2O26]·4H2O and [Cu(bpy)2]3[Mo6V2O26]·4H2O have been prepared by the reaction of the [Mo6V2O26]6- anion with Cu(CH3COO)2 and 1,10-phenanthroline/2,2'-bipyridine in aqueous medium; characterized by Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (1H NMR), Inductively coupled plasma mass spectrometry (ICP-MS), Thermogravimetric Analysis (TGA) and elemental analysis. The compounds show antibacterial activity against Escherichia coli (E. Coli) and Staphylococcus aureus (S. Aureus).
Domestic Self-Sufficiency in Milk-Converting Enzymes
Authors: Musina Olga , Grishkova Anastasiya , Prosekov Alexander
Published: February 2024

Food security is part of national security, self-sufficiency in basic foodstuffs being its important indicator. The situation with cheese production raw materials in the Russian Federation is gradually improving. According to the Ministry of Agriculture, the production of raw milk is growing, which means that the level of self-sufficiency is gradually increasing. However, milk-converting enzymes can create a bottleneck situation since the entire rennet cheese production depends on them. The share of imported milk-coagulating enzyme preparations on the Russian market is 84.3 %. Recombinant milk-converting enzymes dominate both domestic and global cheese-making. However, Russia has neither microbial recombinant chymosins nor coagulants of its own. The domestic commercial production of milk-converting enzymes, especially of modern recombinant preparations, is one of the most relevant issues the domestic food industry will have to tackle in the nearest future.
Effect of Herbal Additives on the Microbiological Profile of Dairy Yoghurts
Authors: Bakin Igor , Korchuganova Anna , Bychkov Dmitry , Mustafina Anna
Published: February 2024

Increasing the survival time and count of viable lactic acid bacteria during storage is an important factor in the probiotic industry. Vegetable powders combined with Lactobacillus bulgaricus and Streptococcus thermophilus can inhibit the growth and reproduction of harmful bacteria in yogurt. This research featured the survival rate of lactic acid bacteria and the microbiological safety of dairy yoghurts fortified with vegetable powders. The research objective was to establish the effect of the additive on the total lactic acid bacterial count in yogurts in order to compare the microbiological indicators with the standards for fortified yogurts. The yoghurts were made by tank method at the municipal dairy plant in Yurga, Kemerovo region. A thermophilic YoFlex culture with Lactobacillus bulgaricus and Streptococcus thermophilus entered the product at the fermentation stage together with dry tomato, fenugreek, and basil powders. The quality tests were conducted at the production laboratory in line with GOST State Standard 31981-2013. All the measurements were done in triplicates, with a significance level of 95 % (p < 0.05). The combined effect of the lactic acid bacteria and the vegetable powders inhibited the growth of E. coli bacteria. The biggest count of viable lactic acid bacteria belonged to the samples fortified with tomato and basil powder. On storage day 1, this sample showed a 62 % higher quantity of mesophilic aerobic and facultative anaerobic microorganisms. Fenugreek and basil leaf powders also increased the viability of yogurt starter cultures compared to the control sample. The number of viable probiotic cells decreased on storage day 8 at 4 ± 2 °C, the recommended shelf life for the new fortified yogurt being 5 days.
Natural Antioxidants and Food Losses: Analysis and Prospects
Authors: Golubev Alexey , Dunchenko Nina , Kuptsova Svetlana
Published: February 2024

The article provides an analysis of food losses at the global level. The authors linked the level of economic well-being to dairy losses. They examined the effect of various aspects on the shelf-life of dairy products and highlighted the differences in the consumption of highfat dairy products in high-income countries. Natural antioxidants could provide an effective solution to the dairy spoilage problem.
Forecasting of water quality parameters of Sandia station in Narmada basin, Central India, using AI techniques
Authors: Tiwari Deepak Kumar , Singh K. R. , Kumar Vijendra
Published: February 2024

In addition to the influence of climate change on water availability and hydrological risks, the effects on water quality are in the early stages of investigation. This study aims to consolidate the latest interdisciplinary research in the application of artificial intelligence (AI) in the field of assessment of water quality parameters and its prediction. This research paper specifically explores the intricate relationship between climate change and water quality parameters at Sandia station, situated within the Narmada basin in Central India. As global climatic patterns continue to shift, the repercussions on water resources have gained prominence. In this work, electrical conductivity is predicted using the KERAS data processing environment on TensorFlow. The root-mean-square error (RMSE), coefficient of determination (R2), Nash–Sutcliffe efficiency (NSE), etc. are calculated between observed and predicted values to assess the model performance. A total of ten models are developed depending upon the input geometry from past monthly timelines. The results indicate that model 8, with ten inputs, performs the best based on the R2 value of 0.889. These results indicate that AI can be very helpful in analyzing the possible threats in the future for drinking water, livestock feeding, irrigation, and so on.
Greenhouse gas emissions from sanitation and wastewater management systems: a review
Authors: Lambiasi Layla , Ddiba Daniel , Andersson Kim , Parvage Masud , Dickin Sarah
Published: February 2024

There is growing awareness of the contribution of sanitation systems to greenhouse gas (GHG) emissions globally, and hence to climate change. However, there is a lack of comprehensive insight into emission sources disaggregated across the entire sanitation chain. This study presents a detailed review and analysis of emission sources from both sewer-based and non-sewered sanitation systems, with a focus on both fugitive emissions and those related to system operation. Our analysis highlights evidence gaps in several areas in the literature: quantifying emissions from non-sewered sanitation systems, with particular gaps related to technologies like biogas toilets and composting toilets; oversight of contextual factors such as environmental conditions and infrastructure operational status in GHG accounting; a dearth of holistic GHG emission studies across the entire sanitation chain comparable to those in the solid waste management sector; and inconsistencies in GHG measurement methods. By pinpointing these gaps, this review provides a robust reference for planning climate mitigation strategies for sanitation and wastewater management systems, emphasizes the urgent need for the incorporation of climate-smart solutions in the sector, e.g. in the design of new and retrofitted infrastructure, and aims to bridge the sustainable development goals related to sanitation and climate action.
ANÁLISE SOBRE O ESTADO DE CONSERVAÇÃO DO LIVRO ESCOLAR EM ESCOLAS PRIMÁRIAS DA CIDADE DE LICHINGA-MOÇAMBIQUE
Authors: Teimoso Agostinho Rosário , Ánica José Marcelo , Naciaia Arlindo Pichesse , Santos João António dos , Gomundanhe Almeida Meque
Published: February 2024

O livro escolar é um material didático de grande importância para transmissão e aquisição de conhecimentos, capacidades e habilidades aos alunos no processo de ensino - aprendizagem. Com este estudo, objetiva-se analisar o estado de conservação do livro escolar em Escolas Primárias da cidade de Lichinga, Província de Niassa, em Moçambique. Metodologicamente, o estudo teve uma abordagem de natureza qualitativa, seguindo o paradigma descritivo. Para a efectivação deste estudo optou-se pela revisão bibliográfica associada a análise de conteúdo. Os resultados obtidos demostram que a conservação do livro escolar é extremamente fulcral para dinamizar a actividade pedagógica e, continua a ser um desafio tendo em conta que os mecanismos usados pelas escolas para a conservação do livro escolar não têm surtido efeitos satisfatórios, uma vez que as escolas não têm armazéns ou locais específicos para conservação do livro escolar, daí que, o envolvimento de todos segmentos da sociedade no sistema educativo é basicamente determinante. Todavia, somos de opinião que se faça uma reflexão profunda sobre a estratégia ou formas de conservação do livro escolar nas escolas com vista a garantir a disponibilidade desse material didático e a melhoria da qualidade de ensino e aprendizagem dos alunos em Moçambique.
Analisis Posisi dan Strategi Pemasaran Buah Naga di Kabupaten Timor Tengah Utara
Authors: Bria Lambertus Nesi , Naif Genoveva Afoan , Funan Anselma Ose
Published: February 2024

Kabupaten Timor Tengah Utara merupakan salah satu kabupaten di daerah tertinggal yang memproduksi buah naga cukup baik. Buah naga telah diusahakan sejak tahun 2017. Tujuan penelitian ini untuk menganalisis posisi dan strategi pemasaran buah naga di Kabupaten Timor Tengah Utara. Penelitian ini merupakan penelitian survei secara langsung dengan memilih jumlah petani buah naga yang tersebar di dua wilayah yaitu Kecamatan Insana, dan Kecamatan Kota Kefamenanu. Pengumpulan data penelitian ini berupa data primer dan sekunder. Hasil penelitian juga menunjukan posisi buah naga berada pada kuadran II bintang (Star) pada tahun 2020 dan 2021. Tahun 2020 buah naga memiliki tingkat pertumbuhan pasar sebesar 15,53 dan pangsa pasarnya sebesar 3,23. Sedangkan pada tahun 2021 tingkat pertumbuhan pasar sebesar 11,93 dan pangsa pasarnya sebesar 1,46. Posisi ini mengindikasikan bahwa buah naga memiliki tingkat pertumbuhan pasar dan pangsa pasar relatif tinggi. Sedangkan strategi pemasaran menunjukan bahwa terdapat empat strategi yaitu produk itu sendiri, harga jual, promosi, dan tempat/lokasi.
Analisis Pendapatan dan Kelayakan Usahatani Jagung Nasa 29 di Kecamatan Pamona Puselemba Kabupaten Poso
Authors: Pamusu Sherley Siseraf , Paelo Yunus
Published: February 2024

Jagung merupakan komoditas tanaman pangan yang dapat dipergunakan sebagai pengganti padi, selain itu juga dapat dipergunakan sebagai pakan ternak. Pengembangan jagung nasa 29 merupakan suatu program akselerasi pengembangan komoditas unggulan daerah Sulawesi Tengah khususnya Kabupaten Poso yang dirancang sebagai suatu upaya terobosan yang diyakini mampu memberikan kontribusi yang tinggi pada peningkatan pendapatan masyarakat khususnya pelaku agribisnis jagung dari hulu sampai hilir, hal ini sesuai dengan program Kementerian Pertanian.  Penelitian ini bertujuan sebagai berikut: 1. Untuk mengetahui besarnya pendapatan pada usahatani jagung satu kali musim tanam di Kecamatan Pamona Puselemba Kabupaten Poso, 2. Untuk mengetahui besarnya R/C pada usahatani jagung satu kali musim tanam di Kecamatan Pamona Puselemba Kabupaten Poso. Sampel petani yang digunakan sebanyak 55 responden dan pengumpulan data menggunakan teknik random sampling method.  Hasil penelitian menunjukkan bahwa rata-rata pendapatan petani  jagung dalam satu musim tanam sebesar Rp 16.554.666, 00 dan R/C ratio usahatani sebesar 3,33 hal ini menunjukkan bahwa usahatani jagung nasa 29 di Kecamatan Pamona Puselemba Kabupaten Poso layak diusahakan untuk mencapai kesejahteraan petani.

 

 

Kata Kunci: jagung nasa 29, pendapatan, analisis lelayakan, usahatani

 
Resistensi Perempuan terhadap Kegiatan Pertambangan Emas di Gunung Tumpang Pitu Kabupaten Banyuwangi
Authors: Mariati Tia , Yuliati Yayuk , Sukesi Keppi
Published: February 2024

Desa Sumberagung merupakan kawasan yang memiliki potensi  wisata laut dan sumberdaya alam berupa emas yang terletak di Gunung Tumpang Pitu. Pertambangan mulai tahun 2015 sampai tahun 2022 berada dibawah anak perusahaan PT Indo Multi Niaga yaitu PT BSI. Permasalahan penelitian :  resistensi masyarakat Desa Sumberagung terhadap IUP PT BSI dan PT. DSI dalam kegiatan eksploitasi Gunung Tumpang Pitu. Tujuan Penelitian melihat resistensi yang dilakukan masyarakat Desa Sumberagung terkait usaha mencabut IUP PT. BSI dan PT. DSI. Rumusan masalah penelitian 1) Bagaimana dampak kegiatan penambangan emas bagi masyarakat Desa Sumberagung? (2) Bagaimana proses munculnya konflik antara masyarakat dengan pihak perusahaan (3) Bagaimana resistensi perempuan terhadap kegiatan eksplotasi tambang emas di Gunung Tumpang Pitu? Penelitian ini mengunakan pendekatan kualitatif deskriptif dengan menggunakan metode studi kasus. Penentuan informan menggunakan Snowball sampling. Analisis data menggunakan komponen analisis Milles and Huberman 2014 model interaktif. Hasil penelitian 1) )Kerusakan diberbagai sector: lingkungan yaitu hilangnya hutan lindung Gunung Tumpang Pitu,, hilangnya endemic hewan dan tumbuhan dan pencemaran air yang mengandung sianida, banjir lumpur, hilangnya sungai katakana, degdradasi tanah.  Sector ekonomi : gagal panen akibat banjir lumpur yang masuk kedalam pertanian, hasil tangkapan nelayan yang mulai berkurang sehingga nelayan harus jauh melaut sampai Bali dan Jember untuk mendapatkan hasil yang maksimal. Sektor sosial  kebising, konflik masyarakat dengan pemerintah dan perusahaan 2) Munculnya konflik dimulai dari diizinkanya PT Hakman Metalindo untuk melakukan tinjauan kandungan emas mulai dari Jember sampai Banyuwangi selama 1 tahun 3) resitensi berupa : Demonstrasi, kayuh sepeda sampai Surabaya, aksi istigosah, aksi pengahadangan alat berat, pembangunan posko penghadangan di pintu masuk Desa Pancer
Seberapa Elastis Permintaan Bawang Putih Indonesia? Sebuah Analisis Regresi Linier Berganda
Authors: Noviaranti Shavira Putri , Zainuddin Ahmad
Published: February 2024

Bawang putih (Allium sativum) merupakan salah satu komoditas pertanian yang sangat dibutuhkan di Indonesia. Bawang putih merupakan salah satu komoditas yang memiliki banyak manfaat. Bawang putih bukan hanya dimanfaatkan sebagai bumbu masak namun juga sebagai obat-obatan.  Permintaan bawang putih di Indonesia selama ini terus mengalami peningkatan. Tujuan penelitian ini yaitu untuk mengetahui faktor-faktor apa saja yang mempengaruhi permintaan bawang putih di Indonesia dan bagaimana proyeksi permintaan bawang putih di Indonesia pada 10 tahun yang akan datang (tahun 2022-2031). Variabel yang digunakan pada penelitian yaitu permintaan bawang putih, jumlah penduduk, pendapatan nasional perkapita, harga riil bawang putih dan harga riil bawang merah di tingkat konsumen. Data yang digunakan dalam penelitian merupakan data time series dari tahun 1985-2020. Metode analisis yang digunakan yaitu analisis regresi berganda dan metode analisis ARIMA (Autoregressive Integrated Moving Average). Hasil penelitian menunjukkan faktor-faktor yang mempengaruhi permintaan bawang putih di Indonesia yaitu pendapatan nasional perkapita dengan koefisien elastisitas 9,14 dan harga riil bawang putih di tingkat konsumen dengan koefisien elastisitas -2,65. Elastisitas permintaan bawang putih di Indonesia dapat dikatakan Elastis. Hasil proyeksi permintaan bawang putih di Indonesia pada 10 tahun yang akan datang (tahun 2022-2031) mengalami perkembangan yang meningkat atau trend positif. Rata-rata pertumbuhan proyeksi permintaan yaitu  1,81% per tahun.