bluuebunny/crossref_metadata_2025 huggingface dataset:
High Schoolers’ Usage Intensity of Mobile Social Media and Nomophobia: Investigating the Mediating Role of Flow Experience
Authors: KARA Mehmet
Published: November 2020

This study aimed to investigate the relationship between high schoolers’ usage intensity of mobile social media and nomophobia through the mediation of flow experience. By adopting flow as a multidimensional construct; skill, machine interaction, and social interaction were included in the analysis as the conditions while concentration, enjoyment, and playfulness were included as the dimensions. A total of 584 adolescent mobile social media users participated in the study. The proposed model was tested through ordinary least-squares regression analysis and bootstrap methods. The findings showed that the usage intensity of the favorite mobile social media significantly predicts both conditions and dimensions of flow experience and nomophobia. In addition, the dimensions of flow experience together with skill significantly mediate the relationship between the usage intensity and nomophobia while the other conditions do not. These findings imply that as students spend more time on their favorite mobile social media, their nomophobic behaviors increase with the mediation of the dimensions and skill; but not the other conditions. The current study contributes to the relevant literature by associating nomophobia with flow experience on multiple mobile social media platforms. It also has implications for parents, school counselors, and educators of high school students.
El aula como laboratorio de experimentación visual
Authors: Lara Osuna Rocío
Published: November 2020

El presente ensayo visual trata de mostrar algunas soluciones a dos problemáticas relacionadas con la tríada ‘Arte - Educación - Tecnología’. La primera es la desconexión existente entre los contenidos que se imparten en las asignaturas de Educación Artística en relación a las nuevas visualidades o formas de creación artística vinculadas a las nuevas tecnologías. La segunda es la falta de aprovechamiento de los recursos tecnológicos disponibles en las aulas en relación a la enseñanza de las artes visuales.

El punto de partida para resolver estas carencias se sitúa en los proyectores como recursos tecnológicos eminentemente visuales que se pueden en contrar en la mayoría de los centros educativos y que a su vez son la base de las creaciones contemporáneas que utilizan la Projection-Based Augmented Reality (PBAR) [Realidad Aumentada Basada en la Proyección].

Tomando como referencia algunas ideas didácticas del cineasta granadino José Val del Omar (1904-1982), se detallan seis ejemplos que proponen la adopción de estrategias educativas basadas en la experimentación con estas tecnologías en la formación inicial del profesorado, transformando el aula en un laboratorio en el que el aprendizaje se acerca a los procesos creativos de las y los artistas profesionales.

Por último, es importante destacar que las imágenes que poseen un marco con línea discontinua gris contienen un hipervínculo que permiten acceder a once videoensayos que amplían la información visual de cada apartado.
GÊNERO E DIREITO: DEBATES TEÓRICOS E POSSIBILIDADES EMPÍRICAS
Authors: Nichnig Claudia Regina
Published: November 2020

As propostas epistemológicas dos estudos feministas e de gênero pensam uma nova perspectiva para os estudos das ciências, ao criticarem a suposta neutralidade, universalidade e objetividade da ciência tradicional. O direito como uma tecnologia que visa regrar as relações sociais não é neutro ou imparcial, pois a partir das lentes dos estudos de gênero podemos perceber uma moral generificada que valora e posiciona diferentemente homens e mulheres na sociedade.
APRESENTAÇÃO
Authors: Kress Tricia , Amorim Simone
Published: November 2020

Critical Pedagogy and Educational Research

Scholar‐practitioners of critical pedagogy and critical research on and extend a number of theories and methods but have the common goal of giving education and research a humanized approach in contemporary society, through Critical Pedagogy. This special issue aims at providing a broad overview of why researchers embrace critical pedagogy and critical research. Inspired by critical theory and other philosophies, Critical Pedagogy seeks to develop awareness and help question beliefs and practices that are alleged to dominate.
ESTUDO EXPLORATÓRIO DAS TAXAS DE EVASÃO DISCENTE DO CST EM AUTOMAÇÃO INDUSTRIAL DO IFS/CAMPUS LAGARTO
Authors: Santos José Osman dos , Espínola  JR José , Pereira Telma Amélia Santos , Reis Igor Adriano de Oliveira , Schetine Danyelle Cruz
Published: November 2020

Atualmente, é crescente a demanda por profissionais qualificados, sobretudo para ocupação de postos ligados às Engenharias. No Brasil, a oferta de tais profissionais constitui um gargalo que tem dificultado o crescimento econômico brasileiro. Assim, o governo brasileiro tem desenvolvido ações para expansão da educação tecnológica. Entretanto, vários estudos têm evidenciado que os índices de evasão no ensino superior são significativos e de causa multifatorial. Isto posto, é importante que sejam investigados os índices de evasão e a identificação dos fatores causadores da evasão no âmbito das diversas instituições e cursos. Dessa forma, esse artigo apresenta os números relativos às taxas de evasão discente a partir do Curso Superior de Tecnologia (CST) em Automação Industrial do IFS/Campus Lagarto e identifica algumas motivações. Dessa forma, esse trabalho contribui com indicadores para orientar políticas internas para redução das taxas.
MedioTec: Concepção de Educação Profissional no Programa Nacional de Acesso ao Ensino Técnico e Emprego
Authors: Mendes Raquel De Oliveira , Santos Elza Ferreira , Nascimento Reinaldo Vasconcelos , Mota Marize da Silva Martins , Lobão Fabiana de Oliveira
Published: November 2020

Neste artigo, discute-se a concepção de educação profissional no contexto do MedioTec, que representa uma ação do Ministério da Educação no Programa Nacional de Acesso ao Ensino Técnico e Emprego (Pronatec). A proposta é refletir sobre o sistema econômico vigente e a crescente demanda por mão-de-obra especializada, além de analisar o processo de implementação do MedioTec no Instituto Federal de Educação, Ciência e Tecnologia de Sergipe. Esta ação foi efetivada com o objetivo de fortalecer as políticas de educação profissional, promover a ampliação da oferta de vagas em cursos técnicos concomitantes ao ensino médio para alunos regularmente matriculados nas redes públicas de educação articulando-a ao setor produtivo. A Educação Profissional brasileira, permeada por entendimentos divergentes acerca do trabalho, tem coexistido com as mais variadas concepções educacionais. Neste cenário, o MedioTec surge como mais uma proposta de formação voltada para o atendimento imediato das necessidades do mercado de trabalho, caracterizada por sua formação unidirecional, fragmentada e aligeirada, explicitada pelas perspectivas de formação técnica para o mundo do trabalho e renda.
MÉTODOS ATIVOS DE APRENDIZAGEM NO ENSINO ONLINE: A OPINIÃO DE UNIVERSITÁRIOS DURANTE A PANDEMIA DE COVID-19
Authors: Dosea Giselle Santana , Santos do Rosário Renan Wesley , Andrade Silva Elisangela , Reis Firmino Larissa , Dos Santos Oliveira Ana Maria
Published: November 2020

Frente à situação da pandemia do COVID-19, as modalidades não presenciais de ensino sofreram ascensão, tornando-se alternativa para dar continuidade à formação acadêmica. Diante disso, esta pesquisa teve como objetivo analisar a opinião de universitários acerca dos métodos ativos de aprendizagem no ensino online. O método utilizado foi a pesquisa de opinião através do aplicativo Google Forms, entre os meses de março e abril de 2020, com estudantes de um curso de fisioterapia de uma instituição privada de ensino. Os resultados apontam que 85% dos acadêmicos consideram o processo de aprendizagem significativo, sendo esse pautado em metodologias ativas de ensino. Todavia, essa modalidade não presencial conta com fragilidades, que são decorrentes de problemas com a internet, ambiente de estudo e dificuldades com as plataformas online. Conclui-se que o papel de centralidade do discente na modalidade de ensino online favorece a aquisição de conhecimentos, no entanto, há interferências que atrapalham o desenvolvimento autônomo do estudante.
A TEORIA DE BERNSTEIN: ESTADO DO CONHECIMENTO EM ARTIGOS PUBLICADOS NO BRASIL NO PERÍODO 2000-2016
Authors: Bezerra Débora Silveira Barros , Eugenio Benedito
Published: November 2020

Este artigo tem como objetivo apresentar o estado do conhecimento sobre a teoria do sociólogo Basil Bernstein, tomando por base os artigos publicados em revistas brasileiras, no portal Scielo, no período 2000-2016. Realizamos um estudo bibliométrico e localizamos 45 artigos, dentre os quais 11 tiveram seus resumos analisados. Os resultados podem ser úteis para futuras análises que empreguem a teoria do Bernstein como base teórica para questões relacionadas ao currículo e às práticas pedagógicas.
O ESCUTAR DO SILÊNCIO – O QUE ESTÁ POR TRÁS DA MUDEZ DA BNCC SOBRE AS ESTRUTURAS DE GÊNERO
Authors: Ramalho Carla Chagas , Vieira José Jairo
Published: November 2020

As políticas públicas educacionais surgem com o propósito de naturalizar fenômenos sociais com consentido pelo Estado. Logo, são políticas que buscam não uma revolução social, mas que buscam amenizar crises que são produzidas, muitas vezes pelo próprio sistema político e ideológico que nos baseia. Assim, este artigo objetivou analisar o que o silêncio sobre a temática gênero na Base Nacional Comum Curricular (BNCC) tem a nos dizer. Para alcançarmos este objetivo, utilizamos como metodologia a análise documental, nos embasamos naia BNCC. Alcançamos como resultados a confirmação da ausência da temática sobre a estrutura de gênero na sociedade na BNCC, mas confirmamos que este silêncio não significa um negligenciamento sobre o assunto, e sim uma confirmação e apoio para a naturalização das estruturas atuais sobre as desigualdades de gênero. Confirmando como essas desigualdades baseiam e fortificam a nossa sociedade capitalista, que tem como propósito a exploração de uma classe ou grupo de pessoas sobre outras. Concluímos que esta visão das questões de gênero deve ser enaltecida e ampliada, com o intuito de um olhar panorâmico sem segmentações sobre gênero e as demais estruturas sociais.
FILTRAGEM DE SINAIS CARDÍACOS UTILIZANDO FILTROS FIR
Authors: Ribeiro da Silva Victor Gabriell , Narayana Duarte Dami Dória
Published: November 2020

A atividade elétrica cardíaca ao ser captada pelo eletrocardiógrafo (ECG), pode conter ruídos indesejáveis. Neste trabalho é proposto a aplicação de um filtro passa-baixas, seguido de dois filtros rejeita banda para recuperação de sinais cardíacos contaminados com ruídos. É utilizado o filtro FIR com método das janelas, este é previamente modelado para que se adeque aos requisitos estabelecidos para a filtragem de sinais cardíacos. Em seguida é realizada a filtragem do sinal com auxílio do programa Matlab utilizando a janela Kaiser. O filtro foi aplicado em três bancos de dados diferentes e avaliados através da relação sinal-ruído, os resultados indicam que a filtragem foi capaz de atenuar consideravelmente os ruídos além de possuir desempenho superior ao filtro de média móvel.
PLANO DE IMPLANTAÇÃO DE ÁREAS VERDES PARA AS ESCOLAS MUNICIPAIS DE UNIÃO DOS PALMARES/AL
Authors: Lopes Ariana Barbosa , Alcides Melissa Mota
Published: November 2020

Com o ritmo acelerado da vida atual, os indivíduos têm cada vez menos contato com áreas verdes. Crianças e jovens em idade escolar passam pelo menos 5 horas diárias na escola. Pensando nisso, ofertar espaços verdes nesses ambientes favorece a interação entre usuários e meio ambiente. Assim, o presente estudo teve como objetivo geral elaborar uma cartilha de paisagismo para escolas municipais a partir do estabelecimento de diretrizes que contribuirão para a implementação de áreas verdes escolares. Busca-se ainda considerar aspectos sociais, ambientais e econômicos destas unidades, através da promoção de práticas que auxiliarão na implantação e manutenção dos espaços verdes inseridos nas escolas. A metodologia adotada buscou obter resultados qualitativos através de levantamentos bibliográficos. O diagnóstico teve como fonte de dados as escolas municipais de União dos Palmares. Foram realizadas análises críticas em relação ao projeto PDDE Sustentável, mostrando que é possível melhorar a qualidade do ensino permitindo contato do aluno com a natureza. A partir dos problemas encontrados, foi possível definir as diretrizes que nortearam este estudo e assim, foi construída a cartilha Paisagismo na Escola, proporcionando um subsídio acessível para que gestores e comunidade escolar possam aplicar na implantação e cuidado com as áreas verdes escolares.
Potencial produtivo e precocidade de linhagens de amendoim em Ribeirão Preto na safra 2019/2020
Authors: Moraes Andrea Rocha Almeida de , Betiol Olavo , Bolonhezi Denizart , Dos Santos João Francisco , De Godoy Ignácio José
Published: November 2020

O estudo teve como objetivo avaliar a produtividade e o grau de maturação de vagens, em linhagens de amendoim rasteiro, para selecionar cultivares com ciclo reduzido. A avaliação da maturação foi realizada em duas datas de amostragem antes da colheita. O experimento foi conduzido no município de Ribeirão Preto, SP, Brasil, em blocos ao acaso, utilizando-se dez linhagens e duas cultivares controles, com os genótipos sendo avaliados aos 119 e 125 dias após a semeadura. Em cada uma das épocas de avaliação, colheram-se amostras de 0,5 m de plantas por linha, para se obter a maturação das vagens com base na tabela de classificação de coloração de maturação de vagens, variando de classe branca a classe preta. Aos 125 DAS realizou-se a colheita total de uma linha das parcelas dos genótipos, para obtenção da produtividade. Realizaram-se também avaliações de porcentagem do número de vagens maduras aos 119 e 125 DAS e porcentagem do ganho no número de vagens maduras do DAS 119 para 125. Com base nos resultados obtidos, pode-se concluir que a linhagem 13.24 apresentou a maior produtividade (7.625 kg ha-1) entre as linhagens avaliadas. A linhagem 13.34 apresentou a maior valor em porcentagem de vagens maduras formadas aos 119 DAS (56,1%). Os maiores acréscimos de porcentagem de ganho no número de vagens maduras em uma semana de plantio foram verificados nas linhagens 13.15 e 13.24. E há linhagens promissoras que serão avaliadas em mais ambientes visando à obtenção de cultivares produtivas de ciclo curto.
WEIGHT SYSTEMS OF CIVILIZATIONS IN SOUTH-EAST ASIA
Authors: Zubko Andrii
Published: November 2020

During the 1st millennium BC, states began to emerge in South-East Asia. But in the beginning, no uniform weight measures have been created there. Development of maritime trade with India in the first centuries of Common Era and the resulting cultural influence from India led to the advent of the Indian-type statehood there, which used Indian weight systems along with local measures. In the 15th – 16th centuries, this region was involved in Chinese maritime trade. As a result, the Chinese or the mixed Chinese-Malayan system of weight measures was used in trade.

This work determines the mass of weight units used by civilizations in South-East Asia, recreates the structure of weight systems, and establishes their correlations and interrelations between various weight systems. The origins of certain weight units and the changes in the structure of weight systems and weight norms over a long period have been traced.
HEN-PARTY IN THE UKRAINIAN TRADITION: HISTORY AND MODERNITY
Authors: Latysheva Daria , Honcharenko Dmytro
Published: November 2020

This article discusses one of the main rites of the wedding cycle – hen-party. He played a significant role in changing the social status of both the girl and the boy. In traditional Ukrainian society, it consisted of six basic elements: «untying and combing the braid of the bride», «wedding invitations», «decorating the wedding branch», «making a sword», «exchanging gifts» and «the first «seat» of the young». However, over the time, under the influence of various factors, it has transformed into a modern «party». In this research, the authors show the evolution of this transformation and contrast the history and modernity of the rite known to all.
Critical role of high-mobility-group proteins in kidney development/cross-talk Wnt/β-catenin signaling pathway
Authors: Ann S. Arndt Mary , D. Wheaton William
Published: November 2020

The treatment of severe acute kidney injury with dialytic support for renal replacement therapy can be life sustaining and permit recovery from critical illness. The high-mobility-group (HMG) proteins are the most abundant non-histone chromatin-associated proteins. HMG proteins are present at high levels in various undifferentiated tissues during embryonic development and reduced in the corresponding adult tissues. We used used in study C57BL/6, HMG+/− and HMG−/− mice and found that HMG is expressed in the mouse embryonic kidney at the cortex area. HMG knockout led to enhanced Wnt/β-catenin signaling pathway. Analysis of siRNA-mediated loss-of-function experiments in embryonic kidney culture confirmed the role of HMG as a key regulator of cortex epithelium differentiation.
Measurement and Influencing Factors of Industrial Water Resource Utilization Efficiency in Yangtze River Economic Belt
Authors: Qi Qi , Song Shengbang
Published: November 2020

The governance of industrial water environment in the Yangtze River Economic Belt (YREB), the demonstration zone of ecological civilization in China, has attracted a growing attention. In this paper, an evaluation index system (EIS) with undesired output is established for industrial water resource utilization efficiency (IWRUE). Next, the stochastic block model (SBM) was adopted to measure the IWRUEs of the 11 YREB provinces in 2003-2017. After that, the Tobit model was employed to examine the influencing factors of the IWRUE. The results show that the YREB provinces differed sharply in IWRUE through the sample period; the downstream provinces achieved relatively satisfactorily IWRUEs, while most provinces in the upstream and midstream performed unsatisfactorily. The downstream of the YREB realized the highest IWRUE, followed in turn by the upstream, and the midstream. The YREB is significantly promoted by economic development, ownership structure, and opening-up, and significantly suppressed by water endowment, technological progress, and government influence.
Diabetes mellitus and COVID-19: current issues of pathogenesis, clinic and therapy. Literature review
Authors: В. І. Цимбалюк  , М. Д. Тронько  , Ю. Г. Антипкін  , В. В. Попова
Published: November 2020

Currently, due to the rapid spread of COVID-19 with the manifestation of severe acute respiratory syndrome, extensive discussions are underway on a number of topical issues related to the best optimal ways to treat patients with diabetes mellitus (DM) during coronavirus pandemic, including problems of susceptibility to this new infection, presence of comorbid pathology, the disease severity and its course, the risks of complications and mortality, as well as the role of drugs used to control glycemia. The coronavirus pandemic is a severe acute respiratory syndrome SARS-CoV2 (COVID-19) dictates the need for immediate study and deep fundamental understanding of the general pathophysiology of the new disease, potentially determines the choice of therapeutic strategy in patients with DM, affected by coronavirus infection.Currently available epidemiological data on COVID-19 do not support the hypothesis that patients with diabetes are at increased risk of infection compared to the general population. To date, it has been established that decompensated DM is an independent factor that aggravates coronavirus infection and significantly increases the risk of fatal disease outcome. Thus, there are the scientific and clinical needs to obtain new data on the methods of treatment currently used in patients with DM infected with COVID-19 to determine their effectiveness and select the optimal treatment strategy, provide a less severe course and better prognosis of disease.Our knowledge of the new coronavirus infection is deepening day by day and the lessons dealing with this new pandemic around the world are extremely important and very valuable in determining the best approach to fighting against this disease. This review provides a brief summary of the general characteristics of COVID-19, and also based on the literature data provides an analytical characteristics of the relationship between this new infectious disease and DM in order to promote a better understanding of the pathogenetic and clinical aspects of this pathological combination, as well as the selection of the most effective therapeutic strategies for patients with COVID-19 and DM
Supplement Usage Pattern in a Group of COVID- 19 Patients in Tehran
Authors: Bagheri Maryam , Haghollahi Fedyeh , Shariat Mamak , Jafarabadi Mina , Aryamloo Parastoo , Rezayof Elahe
Published: November 2020

Objective: The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection, causes severe acute respiratory syndrome and was spread throughout the world in early 2020. The effects of vitamin and micronutrient supplements on the prevention and treatment of COVID- 19 seems challenging in scientific considerations. On the other side generally, experts warn against over-consumption of these supplements.
Materials and methods: This study aimed to investigate the vitamin and micronutrient supplementation usage pattern in past history of patients with COVID-19 via a cross-sectional inquiry. Totally 510 patients referring to the infectious disease clinic of Imam Khomeini Hospital in Tehran from March 2020 to May 2020 were recruited. The inclusion criterion was suspected patients for COVID-19 based on clinical findings and CT scans of the lung. The infected patients included both inpatients (171) and outpatients (339). Demographic information, clinical signs, and the supplement pattern use were collected through a questionnaire and the data were statistically analyzed.
Results: Vitamin D3 intake was reported in 30% (103 patients) of outpatients and 16.5% (28 patients) of hospitalized patients, which is statistically significant (P=0.001). It shows that, the frequency of vitamin D3 consumption in the outpatient group was higher than inpatient group. This significant difference has also been shown in zinc consumption, in 29 patients (9%) outpatients versus 4 patients (2%) inpatients were reported (P=0.007). Multi nominal regression showed that vitamin D3 intake has a supportive effect and reduces the risk of exacerbation and worsening of the disease. (OR=0.291; 95% CI 0.102-.0834, P=0.022).
Conclusion: According to the results of the present study and the findings of other studies, considering the supportive effect of vitamin D3 in reducing the severity of infectious diseases; Clinical trials with an appropriate sample size are recommended to investigate the functional role of this vitamin in improving viral diseases of the respiratory tract.
Effect of Shared Decision-making on Anxiety of Women Recommended for Prenatal Screening Tests in Southeast of Iran
Authors: Moudi Zahra , Jam Raheleh , Ansari Hossein , Montazer Zohour Mostafa
Published: November 2020

Objective: To study the effect of shared decision-making (SDM) on the anxiety of women who were recommended for prenatal screening tests.
Materials and methods: This quasi-experimental study was conducted on a total of 200 pregnant women who referred to the health centers of Zahedan, Iran, for prenatal care within April 7 to September 7, 2019. The control group received routine care, and the intervention group attended a session based on SDM. The demographic characteristics form and Spielberger Six-item State-Trait Anxiety Inventory were filled out before and immediately after the counseling, as well as before receiving the results of maternal serum biochemical markers.
Results: No statistically significant effect of SDM on anxiety was reported between the control and intervention groups immediately after the counseling session (P=0.46). However, the obtained data showed that the mean value of anxiety scores (16.52±3.06) was higher among the women in the intervention group than that reported for the control group (13.80±3.55) on the day before receiving the results of the blood tests (P<0.001). Nevertheless, logistic regression analysis showed only women with a university level of education were likely to have higher anxiety scores than women with lower educational levels (AOR=10.60; 95% CI: 2.07-54.24; P=0.005).
Conclusion: Offering prenatal screening can cause a slight increase in the level of anxiety among women with a university level of education. Therefore, it is required to implement supportive strategies to help high-risk pregnant women in coping with anxiety.
Importance and Motives of Preferential Trade Agreements in the EU's External Trade
Authors: Kawecka-Wyrzykowska Elżbieta
Published: November 2020

As a result of previous multilateral negotiations tariff rates are generally low and cannot explain the reasons for recent proliferation of preferential trade agreements (PTAs). The aim of the paper is to look for other motivations of EU PTAs and to assess their importance for the EU. The main research methods are statistical, review and assessment of WTO documents and critical analysis of literature. First, the present level of tariff protection on selected import markets was estimated. This level illustrates the scale of countries’ interest in their elimination of the existing tariffs. Also the share of preferential imports in the EU extra-trade was calculated and compared with trade on MFN basis. Next, reasons for PTAs were identified. The conclusions prove that 21st century PTAs are mainly motivated not by a reduction of tariffs but by the willingness to reduce the regulatory barriers (contained in rules on public procurement, environmental protection, etc.). The most dynamic trade nowadays involves flows of accessories and services. In this situation the importance of PTAs results from the fact that they serve as instruments eliminating national regulatory barriers faced by exporters of goods and resources on foreign markets. Thus PTAs support production and sales abroad. In the EU political motivations of PTAs are important as well.
The Effect of Board of Directors Characteristics on Risk and Bank Performance: Evidence from Turkey
Authors: Doğan Berna , Ekşi İbrahim Halil
Published: November 2020

A bank, particularly in developing countries like Turkey, is one of the most important institutions in the financial sector. Therefore knowing the factors affecting the performance of banks is important for the development of the sector. One of the factors affecting the risk and profitability of banking sector is the internal factors of the banks. The aim of this paper is to investigate the board of directors’ characteristics and its effect on risk level measured by non-performing loans and on bank performance measured by asset profitability using the Generalized Method of Moments (GMM) estimator. Data from nineteen deposit banks for the period 2012–2018 were used. The result of the study determined that the board size, foreign board members and the independent board members have an effect on both non-performing loans and the return on assets.
Pemberian Jamu Daun Ashitaba pada Ayam Kampung yang Divaksin Tetelo Memperkecil Diameter dan Menekan Jumlah Pulpa Putih Limpa
Authors: Kurnia Ida Ayu Gintan Aristi , Sudira I Wayan , Winaya Ida Bagus Oka
Published: November 2020

Pemberian tanaman herbal diharapkan dapat meningkatkan respons imun sehingga meningkatkan jumlah antibodi. Salah satu tanaman herbal yang dapat meningkatkan respons imun adalah daun ashitaba. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jamu daun ashitaba terhadap perubahan histopatologi limpa ayam kampung. Penelitian ini menggunakan 25 ekor DOC ayam kampung jantan yang terdiri dari lima perlakuan dan masing-masing perlakuan menggunakan lima ekor ayam. Perlakuan P0 (kontrol) divaksin vaksin galur La Sota penyakit tetelo atau Newcastle Disease dan hanya diberikan air minum sedangkan perlakuan P1, P2, P3, dan P4 divaksin tetelo dan diberikan jamu daun ashitaba dengan dosis berturut-turut 250; 500; 1000; 2000 mg/100 mL/hari per oral selama 14 hari. Minggu pertama ayam kampung diberikan air minum kemudian dilanjutkan dengan pemberian jamu daun ashitaba yang dicampurkan ke dalam air minum pada hari ke-7 sampai hari ke-20. Semua kelompok perlakuan divaksinasi tetelo pada hari ke-21, kemudian hari ke-35 ayam kampung penelitian dikorbankan nyawanya dan dilakukan nekropsi serta diambil organ limpa untuk diproses menjadi preparat histopatologi dengan pewarnaan Hematoksilin-Eosin (HE). Hasil penelitian menunjukkan terdapat perubahan histopatologi limpa yang berbeda nyata antara perlakuan P0 (kontrol) dengan perlakuan yang diberikan jamu daun ashitaba. Hasil penelitian dapat disimpulkan bahwa pemberian jamu daun ashitaba menyebabkan penurunan jumlah dan diameter pulpa putih limpa.
A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2
Authors: Xi Cecy , Arianna Di Fazio Arianna , Nadvi Naveed , Patel Karishma , Xiang Michelle , Zhang Hui Emma , Deshpande Chandrika , Low Jason , Wang Xiaonan Trixie , Chen Yiqian , McMillan Christopher , Isaacs Ariel , Osborne Brenna , Vieira de Ribeiro Ana Julia , McCaughan Geoffrey , Mackay Joel , Church Bret , Gorrell Mark
Published: November 2020

Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles in steatosis, insulin resistance, cancers and inflammatory and fibrotic diseases. In addition, DPP4 binds to the spike protein of MERS virus, causing it to be the human cell surface receptor for that virus. DPP4 has been identified as a potential binding target of SARS-CoV-2 spike protein, so this question requires experimental investigation. Understanding protein structure and function requires reliable protocols for production and purification. We developed such strategies for baculovirus generated soluble recombinant human DPP4 (residues 29-766) produced in insect cells. Purification used differential ammonium sulphate precipitation, hydrophobic interaction chromatography, dye affinity chromatography in series with immobilised metal affinity chromatography, and ion exchange chromatography. The binding affinities of DPP4 to the SARS-CoV-2 full-length spike protein and its receptor binding domain (RBD) were measured using surface plasmon resonance and ELISA. This optimised DPP4 purification procedure yielded 1 to 1.8 mg of pure fully active soluble DPP4 protein per litre of insect cell culture with specific activity >30 U/mg, indicative of high purity. No specific binding between DPP4 and CoV-2 spike protein was detected by surface plasmon resonance or ELISA. In summary, a procedure for high purity high yield soluble human DPP4 was achieved and used to show that, unlike MERS-CoV, SARS-CoV-2 does not bind human DPP4.
Association Between Dietary Inflammatory Index and Periodontitis: A Cross-Sectional and Mediation Analysis
Authors: Machado Vanessa , Botelho João , Viana João , Pereira Paula , Lopes Luísa , Proença Luís , Delgado Ana Sintra , Mendes José João
Published: November 2020

Background: We aimed to assess the association between DII and PD and the mediation effect of DII in the association of PD with systemic inflammation. Using the National Health and Nutrition Examination Survey (NHANES) 2009-2010, 2011-2012 and 2013-2014, participants that received periodontal exam and provided dietary recall data were included. The inflammatory potential of diet was calculated via DII. Periodontitis was defined according to the 2012 case definition. The clinical outcomes of interest were mean periodontal probing (PPD), mean clinical attachment loss (CAL) and thresholds of PPD and CAL. White blood cells (WBC), segmented neutrophils and C-reactive protein (CRP) were used as proxies for systemic inflammation. The periodontal measures were regressed across DII values using adjusted multivariate linear regression. Adjusted mediation analysis appraised the influence of DII in the association of periodontitis and systemic inflammation. 10,178 participants were included. DII was significantly correlated with mean PPD, mean CAL, thresholds of PPD and CAL, WBC, segmented neutrophils and DII (p<0.01). A linear regression logistic adjusted for multiple confounding variables confirmed the association between DII and mean PPD (B = 0.02, Standard Error [SE]: 0.02, p<0.001) and CAL (B = -0.02, SE: 0.01, p<0.001). The association of mean PPD and mean CAL with both white blood cells and segmented neutrophils were mediated by DII (from 2.1 to 3.5%, p<0.001). In the 2009-2010 subset, the association of mean CAL with serum CRP was mediated by DII (52.0%, p<0.01). In conclusion, inflammatory diet and PD may be associated. Also, the inflammatory diet significantly mediated the association of leukocyte counts and systemic inflammation with periodontitis.
A New Lorentz Violating Model with Particle’s "Maximum Energy"
Authors: Hu Jinwen , Hu Huan
Published: November 2020

In Lorentz violating models, the rainbow model or theories of Quantum Gravity are usually discussed, and a common feature of these models is that they assume the particle’s energy have a limited value rather than be infinite derived from the Lorentz model. The introduction of "maximum energy" is considered to be necessary in the combination of Quantum theory and Gravity. However, this paper shows that if we just follow the next three principles: (1)we can define the time in the whole space with a prescribed clock synchronization, (2)the time-space is uniform and the space is isotropic and (3)all the inertial systems are equivalent, then we can totally construct a general coordinate transformation to meet the symmetry of inertial systems, and with a special assumption on the speed of light, we can also construct a non-Lorentz transformation between inertial systems to make the particle’s energy have a limited value. Similar to the usual Lorentz violating models, the non-Lorentz transformation in this paper lead to a new modified disperse relation. We applied the obtained disperse relation to analyze the photon’s arrival time lag effect and found that the "maximum energy" derived in our model is somewhat related to the "maximum energy" assumed in the rainbow model.
Pulmonary Arteriovenous Malformation as a Cause of Exercise Intolerance in Children: A Case Report
Authors: Morreale Pierluigi , Notarbartolo Veronica , Allegro Giancarlo , Finazzo Francesca , Vallone Mario Giuseppe , Sanfilippo Maria Fiorella , Comparato Calogero
Published: November 2020

Pulmonary arteriovenous malformation (PAVMs) in children are rare lesions characterized by abnormal low resistance vascular structures connecting a pulmonary artery to a pulmonary vein, resulting in an intrapulmonary right-to-left shunt. The insidious onset and variable signs and symptoms make diagnosis difficult, especially in children. PAVMs  can be single or multiple, congenital or acquired, and up to 47-80% of cases are associated with hereditary hemorrhagic telangiectasia (HHT).We present the  case of a 12-year-old female teenager referred to our center for epistaxis, headache, fatigue and weakness, with evidence of mild oxygen desaturation.  Bubble test showed a right-to-left shunt and pulmonary angio-CT confirmed the diagnosis. Percutaneous selective embolization was performed with full recovery of normal arterial oxygen saturation. When differentiating between mild oxygen desaturation and exercise intolerance in children and adolescents, physicians should be aware of the possibility of PAVMs as a cause. 
Low Grip Strength As a Predictor of Recovery From Total Hip Arthroplasty (THA)
Authors: Gong Long , Ping Yi , Mingsheng Tan
Published: November 2020

BACKGROUND: Some patients undergoing total hip arthroplasty(THA), continue to experience pain, limitations of activities of daily living, even when no specific prosthesis-related technical problem or failure can be identified, and mechanical or biologic problems have been ruled out. This study aims to assess whether low grip strength (GS) is predictive for the bad results after THA.METHODS: A prospective case-control study was designed to assess 202 cases of primary THA between Jan 1, 2018, to May 1, 2018, at an urban tertiary care hospital. Patients were placed into two cohorts based on preoperative GS levels. Differences in length of stay (LOS), 90-day postoperative complications, and hospital readmissions were compared. Besides, the correlations between GS and Harris hip score (HHS) and Short Form-12 (SF-12) score were tested. RESULTS: Eighty-two patients (40.6%) had low GS before THA. Patients with low GS were more likely to be female, older, fracture of femoral head or neck as the primary cause, albumin < 3.5 g/dL, and have a lower body mass index (BMI), higher ASA score, increased rates of the pressure sore, blood transfusion, and LOS compared to normal GS (all p<0.05). Besides, differences in 90-day postoperative complications and hospital readmissions and positive correlations between GS and HHS and SF-12 scores were detected (all p<0.05). CONCLUSION: GS can serve as a useful indicator for assessing muscle weakness before primary THA. Clinicians should be encouraged to include GS assessment in their evaluation of patients who planned to undergo THA in order to optimize the treatment of high-risk individuals.
In-Situ Electrochemical Behaviour of Biocathode Microbial Fuel Cell (MFC)
Authors: Ramana S. Venkata , Cordas Cristina M. , Matias Sara C. , Fonseca Luis Joaquim Pina da
Published: November 2020

In the present work the electrochemical behaviour of microbial cells from a biocathode microbial fuel cell (MFC) functioning with wastewater was evaluated by cyclic voltammetry. In-situ electrochemical assays were performed and, under the tested experimental conditions, the biocathode medium was found to be the most efficient for the cathodic catalysed electrochemical reduction of oxygen. Different controls using sterile media and membranes covering the electrodes were performed and compared with the regular biocathode results. In the biocathode chamber, the presence of bacteria was associated with the enhanced active redox processes and with the higher electrochemical reduction of oxygen activity. The present study is a contribution to the understanding of the viability and advantages of the biocathodes use in MFC.
A low RENAL Nephrometry Score Can Avoid the Need for the Intraoperative Insertion of a Ureteral Catheter in Robot-assisted Partial Nephrectomy
Authors: Nishimura Kenichi , Sawada Yuichi , Sugihara Naoya , Funaki Keisuke , Koyama Kanae , Noda Terutaka , Fukumoto tetsuya , Miura Noriyoshi , Miyauchi yuuki , Kikugawa Tadahiok , Saika Takashi
Published: November 2020

BackgroundIntraoperative urinary collecting system entry (CSE) in robot-assisted partial nephrectomy (RAPN) may cause postoperative urinary leakage and extend the hospitalization. Therefore, identifying and firmly closing the entry sites are important for preventing postoperative urine leakage. In RAPN cases expected to require CSE, we insert a ureteral catheter and inject dye into the renal pelvis to identify the entry sites. We retrospectively analyzed the factors associated with intraoperative CSE in RAPN and explored the indications of intraoperative ureteral catheter indwelling in RAPN.MethodsOf 104 Japanese patients who underwent RAPN at our institution from August 2016 to March 2020, 101 were analyzed. The patients were classified into CSE and non-CSE groups. The patients’ background characteristics, RENAL Nephrometry Score (RNS) and surgical outcomes were analyzed.ResultsIntraoperative CSE was observed in 41 patients (41%). The CSE group had a significantly longer operative time, console time ischemic time, and hospital stay than the non-CSE group. In a multivariable analysis, the N-score (odds ratio [OR]=3.9, P<0.05) and RNS total score excluding the L-score (OR=3.1, P<0.05) were associated with CSE. In a logistic regression analysis, CSE showed a moderate correlation with the RNS total score (area under the curve [AUC]: 0.818, cut-off: 7, sensitivity: 0.80, specificity: 0.68) and RNS total score excluding the L-score (AUC: 0.848, cut-off: 5, sensitivity: 0.83, specificity: 0.73). ConclusionA ureteral catheter should not be placed in patients with an RNS total score ≤6 or RNS total score excluding the L-score of 3 or 4.
Substance Use among Undergraduate Students at Mizan-Tepi University in Ethiopia: Prevalence, Associated Factors, and Its Effect on Health and Academic Performance
Authors: Yosef Tewodros , Getachew Dawit
Published: November 2020

Background: Worldwide, substance use among undergraduate students is a major public health problem and over 29 million people worldwide suffer from substance-related disorders. The use of substances is a growing concern in Ethiopia, in a particular college and university students are the most at risk of substance use and their impacts on the younger generation have become a great concern. Despite some shreds of evidence are available regarding substance use, the problem is not well studied among these groups of the population. Therefore, this study aimed to assess the prevalence, associated factors, and health and academic effects of substance use among undergraduate students at Mizan-Tepi University in Ethiopia.Methods: A cross-sectional study was conducted among 544 regular undergraduate students of Mizan-Tepi University in Ethiopia. Data were collected using a pre-tested self-administered structured questionnaire. The data analysis was done using SPSS version 20. The level of significance in the multivariable logistic regression analysis was declared at a p-value < 0.05.Results: Of the 544 respondents interviewed, the lifetime and current prevalence of substance use among students in Mizan-Tepi University was 62.5% and 27.9% respectively. The most common reported lifetime and current substance use was alcohol drinking with 42.6% and 23% respectively. The study also found that being male (AOR=3.01, 95% CI [1.64-5.53]), being Muslim (AOR=3.13, 95% CI [1.64-5.96]), from urban residence (AOR=3.12, 95% CI [3.01-5.31]), having divorced/separated parents (AOR=3.08, 95% CI [1.64-5.79]), having family substance use (AOR=7.98, 95% CI [5.52-11.6]) and peer substance use (AOR=4.33, 95% CI [2.68-7.26]) were the factors significantly associated with current substance use.Conclusion: The current prevalence of substance use was substantially higher. We can say that substance use is a public health problem among university students in Ethiopia. Higher education institutions should consider designing programs to control substance use among students to improve their student's health and academic performance. Parents should closely monitor the behavior of their children by communicating with teachers.
Time-saving effects using helicopter transportation: comparison to a ground transportation time predicted using a social navigation software
Authors: Jang Ji Young , Kwon Woo-Keun , Moon Jong Ha , Hwang Jun Seong , Kim Yoon Jic , Kim Jang Hun
Published: November 2020

BackgroundPrevious comparison studies regarding two types of transportation, helicopter (HEMS) versus ground emergency medical services (GEMS), have shown underlying heterogeneity as these options have completely different routes and consequent times with reference to one patient. To compare the two types of transportation on a case-by-case basis, we analyzed the retrospectively reviewed HEMS and predicted GEMS data using an open-source navigation software.MethodsPatients transferred by military HEMS from 2016 to 2019 were retrospectively enrolled. The HEMS records on the time of notification, injury point and destination addresses, and time required were reviewed. The GEMS data on distance and the predicted time required were acquired using open-source social navigation systems. Comparison analyses between the two types of transportation were conducted. Further, linear logistic regression analyses were performed on the distance and time of the two options.ResultsA total of 183 patients were enrolled. There was no statistical difference (p=0.3021) in the distance between the two types of transportation, and the HEMS time was significantly shorter than that of GEMS (61.31 vs. 116.92 minutes, p<0.001). The simple linear curves for HEMS and GEMS were separately secured, and two graphs presented the statistical significance (p) as well as reasonable goodness-of-fit (R2). In general, the HEMS graph demonstrates a more gradual slope and narrow distribution compared to that of GEMS.ConclusionIdeally, HEMS is identified as a better transportation modality because it has a shorter transportation time (56 minutes saved) and a low possibility of potential time delays (larger R2). With a strict patient selection, HEMS can rescue injured or emergent patients who are “out of the golden hour.”
A Cambodian-Norwegian Competence Building Program in Child Mental Health: A Qualitative Focus-Group Study
Authors: Hafting Marit , Pat Puthy , Aadland Gunn , Fjermestad Krister , Jegannathan Bhoomikumar
Published: November 2020

BackgroundThe prevalence of mental health and neurodevelopmental disorders in young people is high in low- and middle-income counties, such as Cambodia, as risk factors in the perinatal period, malnutrition, infections and adverse childhood experiences can be abundant due to poverty and/or conflict. Collaboration between institutions from high-income countries and institutions in resource-poor settings for professional development can improve service providers’ knowledge and skills, which is key to bridging the gap between service needs and the ability to meet those needs. The aim of the present article is to describe some significant aspects of a transcultural capacity-building program in child mental health.MethodsA Norwegian team comprised of a pediatrician, a child and adolescent psychiatrist and a child psychologist implemented a program for competence building at Centre for Child and Adolescent Mental Health (Caritas-CCAMH) in Cambodia two weeks per year over a 14-year period. Herein, we explore some aspects of this collaboration from the perspective of the Caritas-CCAMH staff with a qualitative approach using thematic analysis of the transcripts from a focus-group interview with 11 staff members at the end of the 14-year period. Results The multidisciplinary team at Caritas-CCAMH described a learning process characterized by collaboration in planning and implementation. Mixing theory and practice in clinical case discussions with a bio-psycho-social perspective was perceived as the cornerstone of the pedagogical process. Learning by observation and supervision from the Norwegian team led to mastering skills and enhancing self-confidence and job satisfaction. A pedagogical strategy that involved constant reflection back and forth enabled the customization of the content and method of capacity building despite the differences in socio-economic conditions and learning styles that were unfamiliar to the mental health professionals from a high-income country.ConclusionsBuilding knowledge and skills within a dialogic partnership over a significant period of time contributed to learning across cultures. This model of continuity, low-investment and low-intensity capacity-building may enrich the child and adolescent mental health settings in low- and middle-income countries. Furthermore, the model appears feasible for Western professionals with an ambition to support.