bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis Stock Return on Manufacture Sector Post-Covid-19 Pandemic
Authors: . Fathihani , Randyantini Vely , Puji Saputri Ika , Hikmah Perkasa Didin , Al Faruq Abdullah Muhamad , Purwanto Setiyo
Published: July 2023

Manufacturing companies in Indonesia support the government’s role in the development of the economic growth in the country. However, the Covid-19 pandemic has caused problems in making a profit. Therefore, the main problem of this study is to find out and analyze how net profit margin and earning per share affect stock return. Second, knowing and analyzing capital structure as an intervening variable that relates the effect of net profit margin and earning per share to stock return. This study explores the theoretical model and empirical results of how net profit margin and earning per share affects stock return through capital structure. The sampling method was carried out using the purposive sampling method, a data source collection technique that determines the sample with certain considerations. There were 25 companies that were sampled in this study. The data processing was done by multiple linear regression analysis. From various empirical results, there is still little research on the ability of capital structure as a intervening variable to analyze manufacturing companies listed on the Indonesia Stock Exchange. This research is expected to contribute to further research and facilitate the government to approach the development of manufacturing companies to encourage the economy. Meanwhile, investors can be informed about the company’s stock return. The importance of this research can be useful for companies in providing solutions on how to increase net profit margin and earning per share by increasing stock return through capital structure factors.
Keywords: net profit margin, earning per share, capital structure, stock return
Generation X and Millennials: Perception Toward Pay for Individual Performance
Authors: Pitaloka Endang , Naibaho Hastuti , Prasetio Teguh , Kayla Putri Agustono Shula
Published: July 2023

Generational differences will cause different effects on the way employees view and perceive the policies designed by their organizations to motivate them, one of which is performance pay. The study aims to examine the differing perceptions of pay for performance between employees from Generations X and Millennials. This study was conducted by using a survey of which the respondents were from private and public sector organizations. The total number of respondents in this research is 355 employees, which are made up of 156 respondents from Generation X and 199 Millennial respondents. In this study, t-test and Linear regression models were used for hypotheses testing. Results of the t-test showed that there are differences in perceptions of pay for performance between Generations X and Millennials (p < 0.05). Generation X gives a higher positive evaluation on pay for performance compared with Generation Millennials. Results of the regression test showed that pay for performance had a significant effect on employee work motivation for both Generations X and Y (p < 0.05). The results of this study provide insights to organizations into designing appropriate compensation programs based on the demographics of their employees.
Keywords: generation differences, motivation, external regulation, performancecontingent rewards
News Framing on Actors of National Capital City (IKN) Through Cultural Communication of `Tanah' and `Air' Unity in Online Media
Authors: . Dwinarko , Yasya Wichitra , Widodo Aan
Published: July 2023

Against the backdrop of historical communicative actions, the news is the outcome of knowledge in the reality of everyday life. The homo sociological communication model consists of behaviors that refer to collective norms and values, especially laws that declare a requirement, a social order which is then ensured by normative conventions. Through actors and cultural symbols, social action, transcendence, and objectivity become communication acts in the form of news framing. The State Capital or Ibu Kota Negara (IKN) has been the subject of news in the media. This study then aimed to determine news context on the unity of land and water (Tanah dan Air) as a metaphor for the State Capital’s relocation from Jakarta to East Kalimantan Alfred Schutz’s Communicative Action theory. The research used qualitative methodology, while analysis was done using narrative analysis. The findings of this research are the symbols of land and water in the discourse of framing the news of the transfer of the State Capital (IKN) since the administrations of President Sukarno to President Jokowi became a reality of communicative acts with historical significance and cultural communication through land and water rituals. The discourse frame is a value that contributes to profound political and cultural dialogue and equal growth. Sociologically, communicative behavior in new framing results from integrating players historical, cultural, and political interests. Based on the research findings, the recommendation put forward is policy analysis on the transfer of IKN, which must continue to investigate history via cultural communication and social action of players on homo sociologicus and history who possess strategic collective values and norms for sustainable cultural and economic development.
Keywords: news framing, communicative action theory, cultural communication
Use of Social Media in Building Brand Identity Among Young Entrepreneurs
Authors: Yuwono Imam
Published: July 2023

Increasing the number of social media users is a potential for entrepreneurs or young entrepreneurs, especially to develop their businesses on social media. The business world has a potential target of 191 million active social media users. Optimum utilization of social media for business can benefit business people and improve their welfare and the people involved, such as expanding employment opportunities to contribute to community welfare and reduce poverty. One effort that can be made is to build a brand identity on social media by young entrepreneurs. As it is well known, social media users in Indonesia, especially Instagram, are young people. The large number of young entrepreneurs doing business on social media is a challenge in itself to be able to compete to attract the attention of consumers; therefore, the products offered must have an identity so that they are easily recognized among competitors. The research method used is descriptive; the research subjects are young entrepreneurs who had used social media for business for at least 1 year and were selected purposively.
Keywords: brand identity, social media, young entrepreneurs
Is your budget your guide? The willingness to pay for a more sustainable experience in Jericoacoara
Authors: Oliveira Laís Vieira Castro , Romero Cláudia Buhamra Abreu , Silva Clayton Robson Moreira da , Fontenele Raimundo Eduardo Silveira
Published: July 2023

This study seeks to evaluate the willingness of tourists to pay for a more sustainable experience in Jericoacoara, Ceará in Brazil. It consists of a survey of 386 tourists. The data was collected from an online questionnaire administered on location. We used the Contingent Valuation Method (CVM), a descriptive method of analysis, and multiple linear regressions. The results indicate that, on average, tourists are willing to pay R$8,51 in addition to the Sustainable Tourism Fee charged by the Municipality of Jijoca de Jericoacoara (28.4% more). We identified that the variables age, income and dependents influenced their Willingness to Pay (WTP).
New Hybrid MCDM Approach for an Optimal Selection of Maintenance Strategies: Results of a Case Study
Authors: Khanfri N. E. H. , Ouazraoui N. , Simohammed A. , Sellami I.
Published: July 2023

Industrial systems are becoming more sophisticated, and their failure can result in significant losses for the company in terms of production loss, maintenance costs, fines, image loss, etc. Conventional approaches to modeling and evaluating the failure mechanisms of these systems do not consider certain important aspects, such as the interdependencies between failure modes (FMs) with information and data containing uncertainties as they are generally collected from experts’ judgments. These restrictions may lead to improper decision-making. The use of more advanced techniques to model and assess the interdependencies among components’ failures under uncertainties seems to be more than necessary to overcome these deficiencies.

It is in this context that the proposed approach fits. It consists of proposing a hybrid multicriteria decision-aking (MCDM) approach that combines several techniques for a better selection of maintenance strategies. Using the failure mode and effects analysis (FMEA) technique, the potential FMs of components, along with their causes and effects, are identified. The relative importance (or weight) of these FMs is determined using the fuzzy simple additive weighing (FSAW) method based on how they affect the system’s goals. The causal relationships between FMs and their final weights are determined by the fuzzy cognitive maps (FCM) method and the nonlinear Hebbian learning and differential evolution (NHL-DE) algorithm. Finally, based on the final FM weights provided by the FCM, the simple additive weighing (SAW) method is used to select the optimal maintenance strategies. The results of applying the proposed approach to an operating compressor lubrication and sealing oil system demonstrate its importance and usefulness in assisting system operators to efficiently allocate the optimal maintenance strategies, considering the strong correlation between FMs and their effects on system performance while accounting for the uncertainties associated with experts’ judgments. These correlation effects have led to changes in the assigned weights of the selected FMs. Specifically, the FM related to the low output of the lube/seal oil pump, which was initially assigned a lower priority, and with the correlation effects has become the first critical FM. This shift in prioritization emphasizes the need to address this particular FM promptly. By focusing on addressing these high-priority FMs, maintenance efforts can be optimized to prevent or mitigate more severe consequences. Among the various maintenance strategies evaluated, it was determined that the combination of condition-based maintenance (CBM) and precision maintenance (PrM) yields the most favorable outcome in terms of mitigating the impact of accidental failures and undesired events on the selected system.
Comparing Traditional Methods for Rock Masses Volume Estimation and Those Assisted by UAV’s
Authors: Gava Joao Pedro Corona , Souza Felipe Ribeiro , Destro Elton
Published: July 2023

Unmanned Aerial Vehicles (UAVs), Remotely Piloted Aircraft (RPA) or simply Drones, were first utilized for military purposes prior to World War I. With the popularity of its technology, UAVs are now being utilized for photography, cinema, sports, precision agriculture, and mining. UAVs in mining allow professionals to collect data from wide territories that are typically difficult to access, with outstanding cost/benefit ratio, operational time and reduced manpower. The aircraft’s capabilities include reconnaissance of the area, generation of Digital Terrain and Elevation Models (MDTs and MDEs), and monitoring of mining operations. Despite all of the advantages provided by UAVs, there is tremendous space for technological advancement. It is still a new tool that is heavily reliant on ideal climatic conditions, and without an RTK (Real Time Kinematic) station, the error in the coordinates can approach the magnitude of dozens of meters. For these reasons, more conservative miners and government agencies continue to be skeptical of UAV use. This study showed that, when combined with appropriate processing, data gathered with UAVs can produce results comparable to traditional approaches in less time and at comparable prices.
The biogenesis of large extracellular vesicles occurs in mitosis
Authors: Patel Smit , Park Sungjin , Torr Elizabeth , Zhu Dantong , Dureke Ashley-Grace , McIntyre Alina , Severson Jackson , Muzyka Nadiya , Skop Ahna
Published: July 2023

Cells communicate with neighboring cells through shedding and uptake of extracellular vesicles (EVs). EVs are small packages of nucleic acid and protein enclosed in a lipid bilayer. Despite being broadly studied since 2010, the biogenesis of EVs remains elusive. Currently, cells in interphase are thought to shed the bulk of EVs. Given that cancer cells shed more EVs than non-cancerous cells, we hypothesized that the primary origin of large EVs may be mitosis. Here, we demonstrate that the biogenesis of large EVs occurs in mitosis. We found that the canonical EV markers, CD9, CD63, CD81, flotillin-1, and dsRNA, localize to the spindle midzone microtubules, midbody, and midbody remnant (MBR) during mitosis. These EV markers co-localized with the master regulator of cytokinesis, MKLP1, throughout mitosis, suggesting that large EV assembly and packaging occur during mitosis. Next, we showed that standard, commercial, and our newly developed EV isolation methods all isolate MBRs, evidenced by the presence of CD9 and MKLP1 double-positive vesicles. We developed two new methods of large EV isolation utilizing 1.5% PEG 6000 and PEGylated gold nanoparticles. Regardless of the isolation method, EVs are characterized using markers for transmembrane proteins called tetraspanins (CD9, CD63, and CD81), and found that ~99% of all isolated MKLP1-labeled vesicles were also CD9 positive, suggesting that large EVs are MBRs, not a separate class of EVs. Additionally, all isolation methods tested suggest that large EV have translation capacity, distinct from other EV classes. Our results demonstrate that mitotic cells give rise to the bulk of large EVs commonly researched in the field. Importantly, we show that all commercial isolation methods for EVs actually isolate MBRs, suggesting that experiments performed in the EV field are of mitotic origin. This work has broad implications for the assembly and packaging of large EVs, specifically for engineering drug therapeutics and isolation of large EVs, or MBRs, for cancer diagnosis.
Maximizing Wheat Productivity: Synergizing Urine versus Urea Treated Poultry Manure Compost with Zinc and Beneficial Microbes in Semiarid Climates
Authors: Amanullah  , Ali Syed Ashfaq
Published: July 2023

Despite the global importance of wheat production, semiarid regions face significant challenges in achieving high yields. In Pakistan, where wheat cultivation is crucial for food security, addressing these challenges becomes even more critical.This study focuses on improving wheat productivity in semiarid regions, specifically in Pakistan, where water scarcity and nutrient deficiencies pose challenges. The research investigates the effects of poultry manure composts (PMC) and Zn levels on wheat (cv. Khaista 2017) yield and yield components. The aim is to explore sustainable alternatives to chemical fertilizers and maximize the benefits by incorporating beneficial microbes. The field experiment conducted in Harichand Charsadda, Pakistan, employed a randomized complete block design with three replications. The results reveal that wheat crops treated with BMO,, a beneficial microbe, exhibited delayed physiological maturity, taller plants, increased leaf area, more grains per spike, and higher yields. Among the poultry manure sources, urea treated poultry manure (UTPMC) had the most significant effects, while applying 15 kg Zn ha-1 resulted in favorable outcomes. The findings highlight the potential of combining UTPMC and zinc application to enhance wheat productivity in semiarid climates, contributing to sustainable agriculture practices and food security, particularly in Pakistan.
Metagenome-validated Parallel Amplicon Sequencing and Text Mining-based Annotations for Simultaneous Profiling of Bacteria and Fungi: Vaginal Microbiota and Mycobiota in Healthy Women
Authors: Virtanen Seppo , Saqib Schahzad , Kanerva Tinja , Ventin-Holmberg Rebecka , Nieminen Pekka , Holster Tiina , Kalliala Ilkka , Salonen Anne
Published: July 2023

Background
Amplicon sequencing of kingdom-specific tags such as 16S rRNA gene for bacteria and internal transcribed spacer (ITS) region for fungi are widely used for investigating microbial communities. So far most human studies have focused on bacteria while studies on host-associated fungi in health and disease have only recently started to accumulate. To enable cost-effective parallel analysis of bacterial and fungal communities in human and environmental samples, we developed a method where 16S rRNA gene and ITS1 amplicons were pooled together for a single Illumina MiSeq or HiSeq run and analysed after primer-based segregation. Taxonomic assignments were performed with Blast in combination with an iterative text-extraction based filtration approach, which uses extensive literature records from public databases to select the most probable hits that were further validated by shotgun metagenomic sequencing.
Results
Using 50 vaginal samples, we show that the combined run provides comparable results on bacterial composition and diversity to conventional 16S rRNA gene amplicon sequencing. The text-extraction-based taxonomic assignment guided tool provided ecosystem specific bacterial annotations that were confirmed by shotgun metagenomic sequencing (VIRGO, MetaPhlAn, Kraken2). Fungi were identified in 39/50 samples with ITS sequencing while in the metagenome data fungi largely remained undetected due to their low abundance and database issues. Co-abundance analysis of bacteria and fungi did not show strong between-kingdom correlations within the vaginal ecosystem of healthy women.
Conclusion
Combined amplicon sequencing for bacteria and fungi provides a simple and cost-effective method for simultaneous analysis of microbiota and mycobiota within the same samples. Conventional metagenomic sequencing does not provide sufficient fungal genome coverage for their reliable detection in vaginal samples. Text extraction-based annotation tool facilitates ecosystem-specific characterization and interpretation of microbial communities by coupling sequence homology to microbe metadata readily available through public databases.
Pengaruh Likuiditas, Profitabilitas, Leverage dan Ukuran Perusahaan Terhadap Financial Distress Pada Perusahaan Pertambangan yang Terdaftar di Bursa Efek Indonesia Periode Tahun 2015-2018
Authors: Oktavianti Bela , Hizazi Achmad , Mirdah Andi
Published: July 2023

Penelitian ini bertujuan untuk memberikan bukti empiris pengaruh likuiditas, profitabilitas, leverage dan ukuran perusahaan terhadap financial distress pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia periode tahun 2015 – 2018. Pemilihan variabel di dalam penelitian ini didasarkan pada hasil jurnal-jurnal penelitian terdahulu yang menunjukkan hasil yang inkonsisten terhadap faktor  –  faktor yang mempengaruhi financial distress. Pengukuran variabel likuiditas dalam penelitian ini diukur dengan current ratio. Pengukuran variabel profitabilitas dalam penelitian ini diukur dengan return on assets. Pengukuran variabel leverage dalam penelitian ini diukur dengan debt to asset ratio. Pengukuran variabel ukuran perusahaan dalam penelitian ini diukur dengan Ln total aset. Pengukuran variabel financial distress dalam penelitian ini diukur dengan metode Altman Z-Score modifikasi. Populasi dalam penelitian ini adalah perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia periode tahun 2015-2018. Teknik penentuan sampel dalam penelitian ini menggunakan metode purposive sampling dengan kriteria sampel yaitu: 1). Perusahaan pertambangan yang terdaftar di BEI tahun 2015-2018; 2). Perusahaan pertambangan yang tidak mengalami delisting dari Bursa Efek Indonesia dari tahun 2015-2018; dan 3). Perusahaan pertambangan yang menerbitkan laporan keuangan tahunan secara lengkap untuk tahun pelaporan dari tahun 2015-2018. Metode analisis data yang digunakan dalam penelitian ini adalah analisis regresi linear berganda dengan menggunakan software SPSS 22.0. Hasil penelitian menunjukkan bahwa likuiditas, profitabilitas, dan leverage memiliki pengaruh signifikan terhadap financial distress, sedangkan ukuran perusahaan tidak memiliki pengaruh signifikan terhadap financial distress.
PENGARUH PENDIDIKAN, UKURAN USAHA DAN PENGETAHUAN SAKA EMKM TERHADAP KUALITAS LAPORAN KEUANGAN
Authors: A Dwi Annisa , Wiralestari Wiralestari , Tiswiyanti Wiwik
Published: July 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pengaruh pendidikan, ukuran usaha dan pengetahuan SAK EMKM terhadap kualitas laporan keuangan UKM. Populasi dari penelitian ini yaitu UMKM di Kota Jambi yang terdaftar di Dinas Perindustrian dan Perdagangan Kota Jambi periode 2019 dengan sampel 98 UMKM yang dipilih menggunakan random sampling dengan rumus slovin. Metode analisis yang digunakan adalah analisis linear berganda dengan menggunakan program SPSS versi 22. Hasil pengujian menunjukkan bahwa pendidikan, ukuran usaha, dan pengetahuan SAK EMKM berpengaruh secara simultan terhadap kualitas laporan keuangan. Secara parsial variabel pendidikan tidak berpengaruh terhadap kualitas laporan keuangan, sedangkan variabel ukuran usaha dan pengetahuan SAK EMKM berpengaruh positif signifikan terhadap kualitas laporan keuangan.
Pre-clinical and randomized clinical trial with bromhexine and N-acetylcysteine for COVID-19
Authors: Clementino Marco , Neto Roberto da Justa Pires , Mesquita Rafael F. , Lima Mariana S. , Martins Ronaldo , Ferreira Iasmin , Clementino M. , Gondim Rafhaella Nogueira Della Guardia , Magalhães Lyvia Maria Vasconcelos Carneiro , Cavalcante Karene Ferreira , Viana Vania Angelica Feitosa , Mello Liana Perdigão , Souza José K. , Fonseca Xhaulla M.Q.C. , Santos Armênio Aguiar dos , Magalhães Pedro Jorge Caldas , Havt Alexandre , Arruda Érico Antônio Gomes de , Souza Juliano P. , Pontelli Marjorie , Castro Italo A. , Lima Thais M. , Viana Rosa , Jorge Daniel Macedo de Melo , Marcato Priscyla D. , Monteiro Hugo P. , Arruda Eurico , Lima Aldo
Published: July 2023

Treatment options for mild to moderate COVID-19 is limited.
N-acetylcysteine and bromhexine have antiviral activity and show
potential as treatment options against SARS-CoV-2 infections. This study
evaluates the in vitro antiviral effect of bromhexine (BMX) for
SARS-CoV-2 and determines the efficacy of treatment with BMX in
combination with N-acetylcysteine (NAC) to reduce clinical scores in
patients with mild to moderate COVID-19. Upon evidence from pre-clinical
studies, a single center randomized trial of BMX + NAC
(ClinicalTrials.gov Identifier: NCT04928495) with 420 participants in
total took place in Fortaleza, CE, Brazil. Out of the 420 participants
140 received placebo, 140 received NAC alone, and 140 received NAC +
BMX. Patients were monitored for 10-14 days, where physicians recorded
all signs and symptoms reported. Nasopharyngeal swabs and blood samples
were collected for SARS-CoV-2 RNA testing during the first visit, as
well as 3 and 10 days after. Blood samples were collected at first visit
and 10 days after for immuno-inflammatory biomarkers measurements.
Treatment with NAC+BMX reduced clinical scores and symptoms when
compared to placebo group (2/26; 8% vs 7/18; 39%; p < 0.05).
Fever (≥37.8°C) was reduced by NAC + BMX treatment when compared to
treatment with NAC alone and placebo. This study was limited by a
largely vaccinated population. Our analysis showed that BMX reduces
SARS-CoV-2 infection in vitro. Clinical trial results suggested
that combinatory treatment with NAC + BMX is beneficial in mild to
moderate COVID-19.
Ya es hora de desarrollar políticas y prácticas para las personas extuteladas: Primeros comienzos en Portugal
Authors: Cordeiro Pimentel Ana Francisca , Matias Antão Joana , Marceneiro Gaspar João Pedro
Published: July 2023

Se identifican a nivel europeo varias lagunas relativas a la preparación de las personas que abandonan el acogimiento familiar o residencial. La mayoría de estas brechas están relacionadas con la falta de preparación de las personas extuteladas para vivir de manera independiente y con la falta de desarrollo de metodologías y procedimientos de apoyo comunes. En Portugal, la situación es especialmente preocupante ya que, entre los países europeos, tiene uno de los porcentajes más altos de niños en acogimiento residencial. Además, ha habido una inversión mínima en el apoyo a las personas extuteladas en varios niveles: la investigación nacional en el área es limitada, el apoyo para preparar a los jóvenes para abandonar el acogimiento es mínimo y no existe una legislación específica posterior al acogimiento para este colectivo. El “Proyecto OUTogether – Promoviendo la Autonomía de los Niños en Cuidados Alternativos de Salida” fue desarrollado para abordar algunos de estos problemas. El proyecto tenía tres áreas específicas y poblaciones objetivo: 1) abogar por políticas y legislación donde profesionales y jóvenes extutelados trabajaron juntos; 2) desarrollar un programa de capacitación para el personal del acogimiento residencial y 3) desarrollar servicios de apoyo para jóvenes. En este capítulo, los autores se centran en la primera área de acción. El trabajo de promoción implicó que los participantes trabajaran juntos para analizar, discutir y desarrollar recomendaciones para el contexto de lo acogimento y el cuidado posterior. Aunque todavía queda mucho camino por recorrer, esta labor de defensa ha dado lugar a avances en los cambios legislativos y de prácticas. El capítulo comienza con un resumen del proyecto OUTogether y luego se enfoca en la metodología utilizada para el trabajo de incidencia. Esto se analiza como un ejemplo de cómo mejorar la política y la práctica en un país con poco apoyo para los jóvenes que abandonan el acogimiento.
DELTA-9 TETRAHYDROCANNABINOID AND GEMSITABIN COMBINATION ON NON-SMALL CELL (SQUAMOUS CELL, SK-MES-1) LUNG CANCER CELL LINE
Authors: Kalkan Fatih , Özler Mehmet
Published: July 2023

Squamous cell carcinoma falls within the category of non-small cell lung cancers, presenting a considerable challenge in terms of treatment management. There has been growing interest in the potential anti-cancer properties of Delta-9 tetrahydrocannabinol. Gemcitabine, a nucleoside analog, has shown effectiveness against diverse cancer types. This study aimed to assess the combined efficacy of Delta-9 tetrahydrocannabinol and Gemcitabine in treating cancer. The squamous lung cancer cell line required for our study was provided by the stem cell unit. The doses were determined as 5µm/L and 10µm/L for Delta-9 tetrahydrocannabinol, 20 and 40 µm/Lfor Gemcitabine by performing a literature review. In our study, CellViabilityAnalysis by MTT, Xcelligence Real-Time Cell Analysis, Annexin V Apoptosis Flow Cytometry Analysis, Total Oxidant, Antioxidant Status, and Caspase-3 Detection Analysis was performed. Upon evaluating the rates of apoptotic cell death, it was observed that the THC 5 and THC 10 treatment groups exhibited a 30% and 60% increase, respectively, compared to the alcohol group. A significant difference in cytotoxic effect, as determined by MTT, was found between the control group and the Gemsitabin 20, Delta-9 Tetrahydrocannabinol 5µm/L, and Gemsitabin 20+Delta-9 Tetrahydrocannabinol 5µm/L groups (p<0.001). There was a statistically significant difference between the groups regarding TOS (p<0.001). All experimental groups exhibited a higher level of caspase 3 activations, in comparison to the control group. We observed a significant cytotoxic effect of Gemcitabine on squamous cell lung cancer cells. Delta-9 tetrahydrocannabinol, when used alone, exhibited a relatively low cytotoxic effect. However, no significant difference was observed in the groups where Delta-9 tetrahydrocannabinolwas combined with Gemcitabine.
PERTURBATIONS OF IL-10 LEVELS IN THE HYPOPHARYNGEAL CANCER: AN UPDATE
Authors: Saharia Violina , Ahmad Ausaf
Published: July 2023

Hypopharyngeal cancer (HPC) is a disease in which malignant cancer cells accumulated in the tissues of the hypopharynx. Certain viruses are known to exert a significant impact on hypopharyngeal carcinogenesis; however, numerous other factors thought to influence its tumor proliferation and metastasis. Among numerous factors, Interleukin 10 (IL-10) is a prominent anti-inflammatory agent known to evade the immune system via an immunosuppressive condition. Role of IL-10 in the neoplasm is still debatable and inadequately comprehended, but it is one of the many cytokines involved in the growth and maintenance of cancer. In the present review, we explored and highlighted the dual role of IL-10, its secretion level in HPC sufferers, and its role in metastasis and development. We examined the literature focusing on the research that looked into the IL-10 secretion level in the serum and tissues related to the HPC individuals. The advanced clinical stage of hypopharyngeal neoplasm is on the rise and concurrently associated with IL-10 levels. The existing research on IL-10 related to HPC showed differential effects and hence, no clear inference can be attained. The discrepancies observed could be related to variations in sample selection-plasma, tissue, or serum, and differences in assays, variable stage of cancer, comorbidities etc.Although, the higher likelihood of IL-10 detection linked to more advanced tumor stages does imply that the tumor is at least partially attributable to the IL-10 perturbations. This finding still has to be verified by prospective studies on cancer patients in various stages, but the available data are convincing enough to support a viable working theory.
Modified hemipelvectomy techniques in dogs and cats appear well tolerated with good functional outcomes
Authors: Griffin Maureen A. , Altwal Johnny , Culp William T.N. , Seguin Bernard , Wustefeld-Janssens Brandan
Published: July 2023

OBJECTIVE

To describe the clinical characteristics, procedural techniques, complications, and outcomes of dogs and cats undergoing any of the following modified hemipelvectomy techniques: concurrent partial sacrectomy and/or partial vertebrectomy, osseous excision crossing midline, and reconstruction without the use of local musculature.

ANIMALS

23 client-owned animals (20 dogs and 3 cats) that underwent modified hemipelvectomy techniques. Animals that underwent traditional (nonmodified) hemipelvectomy techniques were excluded.

PROCEDURES

The medical records of 3 academic institutions were reviewed, and data were recorded and analyzed.

RESULTS

Modified hemipelvectomy was performed with partial sacrectomy and/or vertebrectomy in 11 dogs, excision crossing pelvic midline with concurrent limb amputation in 5 dogs and 2 cats, and closure without use of native muscle or mesh in 4 dogs and 1 cat. Surgery was performed for tumor excision in all cases. Excision was reported as complete in 16 of 23, incomplete in 6 of 23, and not recorded in 1 of 23 animals. All animals survived to discharge. Only animals undergoing partial sacrectomy/vertebrectomy (4/11) experienced postoperative mobility concerns. Major intra- or post-operative complications (grades 3 and 4) occurred in 2 dogs that underwent partial sacrectomy/vertebrectomy, and 1 of these animals experienced a complication that resulted in death. The median time to death or last follow-up was 251 days (range, 3 to 1,642).

CLINICAL RELEVANCE

The modified hemipelvectomy techniques reported in this cohort were overall well tolerated with good functional outcomes. These findings support the use of these modified hemipelvectomy techniques in dogs and cats, and previous notions regarding tolerable hemipelvectomy procedures should be reconsidered. However, additional studies with larger numbers of patients undergoing modified hemipelvectomy techniques are needed to gain more information.
A retrospective review of cats with suspected false positive results in point-of-care feline leukemia virus tests and concurrent immune-mediated anemia
Authors: Robert Laura Izquierdo , Puig Jordi , Tumbarello Michele , Farigola Montserrat , Seth Mayank , Mesa Ignacio , Bernabe Luis Feo
Published: July 2023

OBJECTIVE

To describe clinical findings, diagnosis, treatment, and survival in 18 cats with anemia of suspected immune-mediated origin (ASIMO) and conflicting results using FeLV diagnosis tests, and to suggest an accurate way to assess their FeLV diagnosis.

ANIMALS

18 cats.

PROCEDURES

Medical records from 5 veterinary institutions were retrospectively reviewed to identify cats with ASIMO, positive results on p27 SNAP ELISA, and negative results on pro-virus PCR testing in peripheral blood, in the absence of other identified triggers. Follow-up was recorded from diagnosis to the time of writing, and survival analysis was performed to assess similarities with previous published data.

RESULTS

18 cats were enrolled from referral centers in Spain, Italy, and the United Kingdom. Both peripheral immune-mediated hemolytic anemia (IMHA; 12/18) and precursor targeted immune-mediated anemia (PIMA; 6/18) were described. When the SNAP ELISA test was rechecked in patients with disease control, SNAP ELISA positive results had become negative. Two cats had a relapse of the ASIMO, and the FeLV SNAP ELISA tested positive again. Other signs of FeLV disease did not appear in any of these patients despite immunosuppression. 14 cats (14/18 [78%]) were alive at the time of writing, and the mean estimated survival time was 769 days.

CLINICAL RELEVANCE

This study describes incongruent FeLV results in cats with ASIMO. It supports the necessity to confirm FeLV SNAP ELISA positive results using additional tools, such as pro-virus PCR testing, as different p27 point-of-care and external serological tests may be inconsistent.
Optimisation of surface characteristics of standard duplex stainless for bio-applications by using electrophoretic deposition: A brief review
Authors: Albaraqaawee Zainab , Abdulsada Shaymaa Abbas
Published: July 2023

There are still some challenges and issues related to the long-term usage of the material, despite the apparent and successful expansion in metallic orthopaedic applications and bone replacement. The goal of the current study is to use 2205 duplex stainless steels instead of 316L stainless steels in medical applications (DSS). The 2205 DSS is characterised by a decreased nickel content, which offers a benefit in medical applications by lowering the release of nickel ions in the body. It is made up of two-phase (austenite and ferrite) microstructures. Additionally, this alloy finds employment in a range of media due to its excellent mechanical strength, hardness, toughness, and corrosion resistance at an affordable price. There is a pertinent issue to take into account with these constraints because of the poor osteoconductivity and the risk of surface contact, which leads to severe corrosion of metallic implants due to the presence of body fluid. This review demonstrates how to modify the surface of DSS-2205 by coating it with hydroxyapatite/multi-wall carbon nanotubes using electrophoretic deposition (EPD) to enhance corrosion resistance, biocompatibility, and osseointegration. It also discusses the impact of the two most crucial EPD variables (potential and time) on the characteristics of the deposited layer in order to determine the best EPD variable values.
Approaches to teaching dialogic speech in English lessons
Authors: Амирханов Н.У. , Эльжуркаева М.Я.
Published: July 2023

Статья посвящена методике обучения диалогической речи учащихся общеобразовательной школы на уроках английского языка. В статье определены проблемы и трудности обучения диалогу, рассмотрены технологии подходов «сверху вниз» и «снизу вверх» в обучении. Данная статья исследует подходы, применяемые в обучении диалогической речи на уроках английского языка. Авторы рассматривают различные методы и стратегии, которые способствуют развитию навыков диалогической коммуникации у учащихся. В работе осуществляется теоретический обзор и практический анализ эффективных подходов, таких как ролевые игры, парные задания, дискуссии и другие. Более того, статья описывает примеры урочной и внеурочной деятельности, направленной на развитие диалогической речи. Исследование предоставляет ценную информацию для преподавателей, помогая им выбирать подходы, наиболее соответствующие целям и потребностям учащихся, и способствуя развитию их коммуникативных навыков на английском языке.

The article is dedicated to the methodology of teaching dialogic speech to secondary school students in English lessons. The article identifies the problems and difficulties of teaching dialogue, examines the technologies of the "top-down" and "bottom-up" approaches in teaching. The article is devoted to the methodology of teaching dialogic speech to secondary school students in English lessons. The article identifies the problems and difficulties of teaching dialogue, examines the technologies of the "top-down" and "bottom-up" approaches in teaching. This article explores the approaches used in teaching dialogic speech in English lessons. The authors consider various methods and strategies that contribute to the development of dialogic communication skills in students. The paper provides a theoretical review and practical analysis of effective approaches, such as role-playing games, paired tasks, discussions and others. Moreover, the article describes examples of scheduled and extracurricular activities aimed at the development of dialogic speech. The study provides valuable information for teachers, helping them to choose approaches that best meet the goals and needs of students, and contributing to the development of their communication skills in English.
Historical and pedagogical research of abbreviations in the Chinese language: review and analysis
Authors: Шуай Ян.
Published: July 2023

Сокращения являются распространенным языковым явлением в китайском языке, и исследования в этой области проводятся с древности до наших дней. В целом, исследования сокращений претерпели эволюцию от основанного на опытно-семантическом анализе к комбинированному изучению синтаксиса, семантики и прагматики, а также от статического анализа к комбинированному статическому и динамическому анализу. В данной статье кратко описывается история исследований сокращений в китайском языке, начиная с древних учений и периода начальной школы. Данное исследование представляет собой обзор и анализ истории и использования сокращений в китайском языке. Авторы проводят историко-педагогическое исследование, чтобы изучить процесс формирования и эволюции сокращений в китайском языке на протяжении времени. В статье рассматриваются основные причины и механизмы образования сокращений, их роль в повседневной коммуникации и в различных областях жизни китайского общества. Анализируются различные типы сокращений и их влияние на понимание и использование китайского языка. Исследование также обсуждает педагогические аспекты использования сокращений в преподавании китайского языка и выдвигает предложения для развития компетенции в обращении с сокращениями.

Abbreviations are a common linguistic phenomenon in Chinese, and research in this area has been conducted from antiquity to the present day. In general, studies of abbreviations have evolved from experimental semantic analysis based on a combined study of syntax, semantics and pragmatics, as well as from static analysis to combined static and dynamic analysis. This article briefly describes the history of research on abbreviations in the Chinese language, starting with ancient teachings and the period of elementary school. This study is a review and analysis of the history and use of abbreviations in the Chinese language. The authors conduct a historical and pedagogical study to study the process of formation and evolution of abbreviations in the Chinese language over time. The article examines the main causes and mechanisms of the formation of abbreviations, their role in everyday communication and in various areas of Chinese society. The various types of abbreviations and their impact on the understanding and use of the Chinese language are analyzed. The study also discusses the pedagogical aspects of the use of abbreviations in teaching Chinese and puts forward proposals for the development of competence in dealing with abbreviations.
EVALUATION OF DRAINAGE SYSTEM IN SIMOREJO SETTLEMENT AREA, SIMOMULYO VILLAGE, SUKOMANUNGGAL SUB-DISTRICT, SURABAYA CITY
Authors: Satriya M Gilang Ridwanafriansyah , Saves Faradlillah
Published: July 2023

Flooding frequently occurs in the Simorejo Settlement Area, Simomulyo Village, Sukomanunggal Sub-District, Surabaya City, Indonesia. Recent flooding revealed that the existing channel's capacity was insufficient to handle flood discharge. Therefore, an evaluation of the drainage channels was carried out to determine design and existing flood discharges and channel re-designing measures. Rain data from 2012 to 2021, for the last decade, was used in the evaluation. Maximum rainfall was calculated using the arithmetic method, while design and existing channel discharges were calculated based on the rational method with a maximum rainfall of 2 years, 5 years, and 10 years. The calculation results showed that the channel condition was unable to accommodate the planned flood discharge with a 2-year, 5-year, and 10-year return period. Consequently, re-designing was carried out using a trial and error method until the channel was able to accommodate the design of flood discharge. The re-designing process resulted in an enlarged drainage channel cross-section with dimensions of 1.2 m x 1 m x 1 m.
Management of mattresses in the prevention of healthcare-associated infection: a cross-sectional study
Authors: Giroti Alessandra Lyrio Barbosa , Ferreira Adriano Menis , Cury Elenir Rose Jardim , Rigotti Marcelo Alessandro , Carneiro Liliane Moretti , Diniz Maiara Oliveira
Published: July 2023

Introduction: Healthcare Associated Infection (HAI) threatens patient safety and can be associated with contamination of surfaces such as mattresses. This study aimed to identify the criteria for the acquisition and conservation of mattresses in hospitals and Homes for the Aged (HA) as an infection prevention strategy. Outlining: Cross-sectional study carried out with 18 institutions. Data were collected through a structured interview with the person responsible for administration, hospitality sector or the Hospital Infection Control Committee, using a validated instrument. Data analysis was performed using descriptive statistics. Results: Five HA and 8 Hospitals partook the study. Acquisition by direct purchase prevails (94.4%), with a periodicity of 1 to 5 years (50%). All mattresses purchased are foam ones, due to user comfort (44.4%) and resistance (38.9%). Waterproof cover is used by 83% of the services, made of “napa” (72.2%) and “corvin” (66.7%) for easy sanitizing (77.8%). “During the concurrent cleaning” is the most mentioned time to evaluate the integrity of the mattress (38.8%) and coating (50%). Implications: it was observed that there is no systematic management for the acquisition and maintenance of mattresses. This highlights the need to improve the care with patient bed in order to prevent healthcare-associated infections.
Theoretical substantiation of the design parameters of the rotating reflective cone of the sprinkler nozzle, providing increased wind resistance of rain
Authors: Kravchuk Alexey Vladimirovich , Rusinov Dmitry Alekseevich
Published: July 2023

The article deals with the theoretical question of substantiating the design parameters of a rotating deflector cone providing the creation of a rain cloud with increased wind resistance. The optimal geometric parameters of the rotating deflector cone are determined. The results of laboratory studies are presented, during which the effect of changing the angle of departure of a raindrop descending from a rotating deflector cone on the amount of rain loss on evaporation and wind drift, as well as the irrigation radius, was investigated. It has been found that the use of sprinkler nozzles with a rotating deflector cone can increase the wind resistance of the rain created while maintaining the irrigation radius and reduce water loss by evaporation up to 9.8% compared with rain nozzles with a non-rotating smooth deflector cone.
PENGARUH FRAKSI VOLUME TERHADAP KEKUATAN BENDING PADA KOMPOSIT BERPENGUAT SERAT DAUN SISAL MENGGUNAKAN RESIN BQTN 157-EX
Authors: Zulmiardi Zulmiardi , Abubakar Abubakar , Meriatna Meriatna , Yudistira Yudistira
Published: July 2023

Penelitian ini bertujuan untuk membuat prototipe komposit plastik berpenguat serat daun sisal, dengan variasi fraksi volume (Vf) 5%, 10%, 15% dengan perlakuan alkali sebesar 5% . Komposisi serat disusun didalam cetakan dengan arah memanjang (00) dengan orientasi laminat acak, menggunakan metode Vacuum Assisted Resin Infusion (VARI). Dari penggunaan metode ini dapat mengeluarkan udara yang terperangkap masuk pada spesimen komposit maka diharapkan nilai dari kekuatan uji bending menjadi lebih besar. Hasil dari proses pengujian bending diharapkan nilai kekuatan uji bending terbesar dengan fraksi volume 15% dengan nilai rata-rata yaitu 153,76 Newton, untuk pengujian bending terendah pada fraksi volume 5% dengan nilai rata-rata 78,45 Newton.. Bisa disimpulkan, untuk komposit berpenguat serat dari daun sisal menggunakanResin BQTN 157-EX mempunyai kemampuan yang cukup besar kalau diaplikasikan sebagai material struktural.
Pengaruh Perbandingan Waktu Delignifikasi Dan Konsentrasi NaOH Dalam Pembuatan Gula Reduksi Dari Kulit Kopi Arabika (coffea Arabica)
Authors: Masrullita Masrullita , Suryati Suryati , Rozah Tiara , Safriwardy Ferri
Published: July 2023

Kopi  adalah  salah  satu  tanaman  yang  menghasilkan  produk  samping dalam  proses  pengolahannya yakni  kulit  kopi. Tujuan penelitian ini adalah untuk mengkaji pengaruh waktu delignifikasi dan konsentrasi NaOH pada hasil gula reduksi. Penelitian ini sudah banyak dilakukan sebelumnya menggunakan pelarut etanol dan asam kuat, yang belum dilakukan adalah menggunakan pelarut basa kuat. Penelitian ini menggunakan pelarut NaOH untuk mendegradasi lignin yang terdapat pada bahan baku. Pada proses pretreatment fisika kulit kopi dibersihkan lalu dimasukkan kedalam oven selama 24 jam, tujuannya untuk menghilangkan kadar air, kemudian dihaluskan menggunakan blender agar diperoleh hasil berbentuk serbuk. Proses delignifikasi menggunakan metode organosolv dengan variasi konsentrasi NaOH 1%, 3%, 5% dan 7% dengan variasi waktu delignifikasi 30 menit, 60 menit, 90 menit dan 120 menit. Proses hidrolisis menggunakan katalis H2SO4 1% pada suhu 100oC  selama 4 jam, kemudian diuji yield, densitas dan kadar gula reduksi menggunakan metode luff schrool untuk mengetahui berapa banyak kadar gula reduksi pada kulit kopi arabika. Kadar gula reduksi tertinggi terdapat pada konsentrasi NaOH 7% dan waktu delignifikasi 120 menit sebesar 68,28%. Yield tertinggi terdapat pada konsentrasi NaOH 7% dan waktu delignifikasi 120 menit sebesar 60,98%. Densitas tertinggi terdapat pada konsentrasi NaOH 7% dan waktu delignifikasi 120 menit sebesar 0,985 g/cm3. Hasil penelitian menunjukkan semakin besar konsentrasi NaOH dan lama waktu delignifikasi maka kadar gula reduksi yang dihasilkan akan semakin banyak.
Posesión de animales exóticos como mascotas en México
Authors: Carpio Domínguez José Luis
Published: July 2023

La posesión de animales exóticos es un fenómeno en incremento y una de las principales causas de tráfico legal e ilegal de fauna, por lo que es necesaria una aproximación criminológica del fenómeno para analizar los contextos sociales, económicos y políticos del fenómeno. Este articulo explora los casos de posesión de animales exóticos en México, a través de la consulta en medios hemerográficos y su relación con fenómenos sociopolíticos en el país durante el periodo 2008-2018. Encontramos que la posesión de animales exóticos tiene implicaciones sociales, de seguridad, políticas y económicas, y a través de los años ha ido incrementando, incluso frente los esfuerzos de las autoridades por atenderla y regularla, además se encuentra relacionado con otras formas de criminalidad en el país, por lo tanto, sigue siendo un tema pendiente en la investigación criminológica sobre tráfico ilegal de vida silvestre en México.