bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBADANAN HUKUM FINTECH SEBAGAI INSTRUMEN PENGATURAN PERSAINGAN USAHA YANG SEHAT
Authors: Handayani Otih , Sulistiyono Adi
Published: July 2020

Revolusi Industri 4.0. melahirkan Financial Technology (Fintech) sebagai paradigma baru di bidang jasa keuangan merupakan akselerasi pemberian pinjaman dana dengan memanfaatkan proses otomatis dan menyederhanakan proses pinjaman. Penelitian ini bertujuan untuk membadankan Hukum Fintech sebagai instrumen pengaturan persaingan usaha yang sehat. Penelitian ini adalah penelitian hukum doktrinal/normatif dengan pendekatan perundang-undangan. Data dikumpulkan dengan studi kepustakaan, dianalisis secara kualitatif. Hasil Penelitian mendeskripsikan fenomena Asosiasi Fintech yang beranggotakan 78% menetapkan bunga pinjaman 0,8 persen per hari yang mengakibatkan konsumen kurang memiliki pilihan apabila menggunakan Fintech. Lemahnya instrumen hukum berdampak pada terjadinya persaingan usaha yang tidak sehat yang salah satunya berbentuk kartel. Pembadanan hukum Fintech akan mampu meniadakan kartel Fintech dan memberikan perlindungan hukum bagi konsumen mendapatkan perlakuan yang fair sehingga dapat mendorong pertumbuhan ekonomi dan bekerjanya ekonomi pasar yang wajar.
URGENSI PENEGAKAN HUKUM PROGRESIF UNTUK MENGEMBALIKAN KERUGIAN NEGARA DALAM TINDAK PIDANA KORUPSI
Authors: Mahmud Ade
Published: July 2020

Tindak pidana korupsi telah menimbulkan kerugian negara cukup besar. Indonesia perlu menerapkan cara berhukum yang khusus untuk memerangi korupsi agar aset hasil korupsi yang dikuasai pelaku dapat dikembalikan. Realitas menunjukan nilai kerugian negara jauh lebih besar dibandingkan dengan uang yang berhasil dikembalikan ke negara. Perkembangan modus operandi tindak pidana korupsi dalam menyembunyikan aset hasil korupsi mendorong urgensi menerapkan strategi penegak hukum progresif dengan melaksanakan 2 (dua) langkah strategis yaitu: (1) melakukan tindakan rule breaking dalam bentuk tindakan penyitaan terhadap aset terdakwa untuk jaminan pembayaran kerugian negara; (2) hakim memberikan putusan contra legem berupa kewajiban membayar uang pengganti tanpa subsider yang didahului dengan sita jaminan sehingga akan menutup ruang terdakwa untuk lepas dari pembayaran uang pengganti.
Dwujęzyczność u progu edukacji szkolnej – interdyscyplinarny projekt badawczy
Authors: Otwinowska Agnieszka , Banasik Natalia , Białecka-Pikul Marta , Kiebzak-Mandera Dorota , Kuś Katarzyna , Miękisz Aneta , Szewczyk Jakub , Cywińska Maria , Kacprzak Agnieszka , Karwala Magda , Kołak Joanna , Łuniewska Magda , Mieszkowska Karolina , Wodniecka Zofia , Haman Ewa
Published: July 2020

The paper describes a Polish research project which aims at creating a cognitive and linguistic profile of the Polish-English bilingual child at the school entrance age. With the increase in the number of bilingual children due to economic migrations, researchers, educators and practitioners are often faced with diagnostic dilemmas which arise from similarities in bilingual language acquisition in natural settings and Specific Language Impairment (SLI). The study, which aims at disentangling the effects of bilingualism from those of SLI, is a part of European cooperation programme COST Action IS0408/Bi-SLI. The aim of the Polish team is to create and test a set of tools which can be used for developing norms of typical bilingual development for Polish-English children entering school education.
Chloride-Induced Stress Corrosion Cracking Tester for Austenitic Stainless Steel
Authors: Jeong Jae-Yoon , Lee Myeong-Woo , Kim Yun-Jae , Lam Poh-Sang , Duncan Andrew J.
Published: July 2020

In this paper, a new experimental tester was designed to improve the stability in load measurement and imposed environment for chloride-induced stress corrosion cracking (CISCC) testing of austenitic stainless steels that are used to construct spent nuclear fuel dry storage canisters. By fabricating compact tension specimens using the UNS S30400 stainless steel, the test is conducted by immersing the specimen in 5 % salinity artificial seawater at 50°C. From the measured load, the stress intensity factor is calculated and the crack length is measured by an optical microscope. The present experimental data confirm the existing findings that the CISCC growth rate is insensitive to the stress intensity factor but is dominantly affected by the specimen surface temperature. The crack growth rate also confirms the existing model.
Advances in IgG4-related Hepatobiliary Disease
Authors: Moon Sung-Hoon
Published: July 2020

The emergence of the new disease entity of steroid responsive immunoglobulin G4 (IgG4)-related hepatobiliary disease has generated considerable interest among hepatobiliary society. IgG4-related hepatobiliary disease refers to mainly IgG4-related sclerosing cholangitis (IgG4-SC), and includes a small number of IgG4-related hepatopathy. As IgG4-SC responds well to glucocorticoid therapy, IgG4-SC should be differentiated from cholangiocarcinoma and primary sclerosing cholangitis. Timely diagnosis of IgG4-SC can lead clinicians to prescribe adequate glucocorticoid treatment that can reverse bile duct strictures and cholestatic liver function. Differentiation of IgG4-SC from primary sclerosing cholangitis is sometimes challenging because serum IgG4 and tissue IgG4 have demonstrated low positive predictive value in this setting. Recent research suggested that blood IgG4/IgG RNA ratio by quantitative polymerase chain reaction can be used for differentiation. Although most patients with IgG4-SC/autoimmune pancreatitis respond to glucocorticoid therapy, they frequently experience relapse of disease. The suggested relapse factors included very high serum IgG4, diffuse enlargement of the pancreas, proximal IgG4-SC, and multi-organ involvement. This review discusses the recent advances in the pathogenesis, diagnosis, management, disease relapse, and monitoring disease activity of IgG4-SC.
A Serous Cystic Neoplasm of the Pancreas with Synchronous Pancreatic Ductal Adenocarcinoma
Authors: Park Hyun Jin , Hwang Jun Seong , Ko Sung Woo , So Hoonsub , Kwon Jae Woo , Song Tae Jun
Published: July 2020

Serous cystic neoplasm (SCN) represents 10–16% of cystic pancreatic lesions, first classified by Compagno and Oertel at 1978. In contrast to mucinous cystic neoplasm or intraductal papillary mucinous neoplasm of pancreas which have malignant potential, SCN is thought to be exclusively benign as solitary lesion in nearly all cases. There has been rare reported association between the SCN and pancreatic ductal adenocarcinoma, and few cases were documented their coexistence. In this report, we present the case of SCN of the pancreas with literature review in which synchronous pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasm coexist together.
Cholangitis Caused by Hereditary Spherocytosis in Adulthood Treated by Endoscopic Retrograde Cholangiopancreatography
Authors: Park Tae Yeong , Jun Jae Hyuck , Kang Huapyong , Doh Young Seok , Jang Ji Woong , Baek Il Hyun , Jung Sung Hee
Published: July 2020

Hereditary spherocytosis is a disease caused by deficiency of erythrocyte lipid membrane protein. Hereditary spherocytosis shows hemolysis of erythrocyte, and it leads to anemia, jaundice by elevation of indirect bilirubin. Almost of patients are diagnosed in their infancy, and can be cured by splenectomy about their age 6–7. Herein, we report a rare case of 33-year-old male was suffered from gallbladder stone and cholangitis those are thought to be the late complications of hereditary spherocytosis. We performed endoscopic retrograde cholangiopancreaticography to remove common bile duct stones. After he got cholecystectomy and splenectomy, there was no recurrence of choledocholithiasis. This is the first case in Korea who didn’t undergo splenectomy until grown up, shows cholangitis as a late disease manifestation of hereditary spherocytosis.
The Screening and Early Detection of Pancreatic Cancer: Who, When, and How?
Authors: Chang Jae Hyuck
Published: July 2020

More than 80% of patients with pancreatic ductal adenocarcinoma (PDA) present with symptomatic, surgically unresectable disease. If a “stage shift” from the current 20% resectable proportion to greater by early detection can be achieved, it will unequivocally lead to improved survival in this otherwise dismal disease. Although the goal of early detection of PDA is laudable, the relatively low prevalence PDA renders general population screening infeasible. To avoid the perils of overdiagnosis and to focus early detection efforts on individuals deemed to be at higher-than-average risk, we need to define those subsets of individuals, such as familial kindred and patients with precursor cystic lesions, chronic pancreatitis, and new-onset diabetes. The next step is to determine when and how often to conduct surveillance in the atrisk individuals and the modalities (biomarkers and imaging) that will be used in the surveillance and diagnostic settings, respectively. Nonetheless, vast challenges still remain in terms of validated blood-based biomarkers, imaging modality, and when and how often the surveillance.
EFFECT OF COMPRESSION SOCKS ON POSTURAL BALANCE AMONG UNIVERSITY NETBALL PLAYERS
Authors: Hasan Hosni
Published: July 2020

The purpose of this study was to observe the effects of wearing compression socks on postural balance in university netball players. Fourteen advanced learners' netball players performed three trials (20 seconds for each trial) of dynamic postural balance test on Biodex Stability System, in two socks conditions, (a) Normal Socks and (b) Compression Socks.  Data on overall, anterior/posterior and medial/lateral stability indexes were analyzed using Paired Sample T-tests. Results revealed that wearing compression materials significantly enhanced static and dynamic postural balance among the university netball players. The improvement in the key variables is likely to have occurred through enhanced somatosensory feedback information that was received the lower limbs to regulate better postural stability. It is suggested that compression socks can be used by netball players to improve their postural stability possibly during shooting performance.
Infiltrative lymphocytic hypophysitis successfully treated with rituximab and mycophenolate mofetil
Authors: Lin Mike , Tsang Venessa , Brewer Janice , Clifton-Bligh Roderick , Gild Matti L
Published: July 2020

Lymphocytic hypophysitis is a rare neuroendocrine disease characterised by an autoimmune inflammatory disorder of the pituitary gland. We report a 50-year-old woman who presented with headaches and bilateral sixth cranial nerve palsies. MRI of the pituitary revealed extensive fibrosis involving the sellar and extending into both cavernous sinuses causing bilateral occlusion of the internal carotid arteries (ICA). Transphenoidal biopsy confirmed the diagnosis of infiltrative fibrotic lymphocytic hypophysitis. Symptoms resolved with high dose of oral steroids but relapsed on tapering, requiring several treatments of i.v. pulse steroids over 8 months. Rituximab combined with mycophenolate mofetil was required to achieve long-term symptom relief. Serial MRI pituitary imaging showed stabilisation of her disease without reduction in sellar mass or regression of ICA occlusion. The patient’s brain remained perfused solely by her posterior circulation. This case demonstrates an unusual presentation of a rare disease and highlights a successful steroid-sparing regimen in a refractory setting.

Learning points:

Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. In exceptional cases, there is infiltration of the cavernous sinus with subsequent occlusion of the internal carotid arteries.

First-line treatment of lymphocytic hypophysitis is high-dose glucocorticoids. Relapse after tapering or discontinuation is common and its use is limited by long-term adverse effects.

There is a paucity of data for treatment of refractory lymphocytic hypophysitis. Goals of treatment should include improvement in symptoms, correction of hormonal insufficiencies, reduction in lesion size and prevention of recurrence.

Steroid-sparing immunosuppressive drugs such as rituximab and mycophenolate mofetil have been successful in case reports. This therapeutic combination represents a viable alternative treatment for refractory disease.
Desafios ao encontro: contribuições de Moreno e Freire para a educação de jovens e adultos
Authors: Amaral Mara Solange da Silva , Costa-Renders Elizabete Cristina
Published: July 2020

O fazer docente das professoras e dos professores da Educação de Jovens e Adultos (EJA) apresenta em seu cotidiano múltiplos desafios relacionados a questões socioeconômicas, de saúde pública, de bem-estar, cognitivas e de relacionamento. Carrega, ainda, todo o legado histórico do combate ao analfabetismo, das desigualdades sociais e das fragilidades das políticas públicas educacionais desta modalidade de ensino. Neste cenário desafiador, aproximações teóricas entre Jacob Levy Moreno e Paulo Freire contribuem para uma leitura crítica das situações-limite presentes no dia a dia do trabalho docente. O Sociodrama, como método desta pesquisa, aponta a espontaneidade-criatividade como possibilidade para superação das densas conservas culturais instaladas e da possibilidade do Encontro.
The applications of psychodrama in the PANDEMIC COVID-19 in preprint publications
Authors: Fleury Heloisa Junqueira
Published: July 2020

A troca de informações é essencial para o desenvolvimento da ciência. Com a eclosão da pandemia COVID-19 e consequente isolamento social, psicoterapeutas e profissionais que trabalham com grupos buscaram informações para uma rápida adaptação à telepsicologia ou telepsicodrama. O compartilhamento de experiências com o psicodrama on-line tornou-se urgente. Apesar de estarmos testemunhando inúmeros sociodramas, aulas e supervisões on-line, utilizando webinars e outras plataformas em rede social, consideramos que informações são insuficientes, precisamos de recursos para a seleção e a identificação do conhecimento científico. Todo manuscrito submetido para publicação em periódico científi co passa por um processo de revisão por pareceristas duplo-cego, ou seja, o sistema garante o anonimato de autores e pareceristas. Esse processo pode levar meses, atrasando o compartilhamento de estudos relevantes. A necessidade de compartilhar resultados de pesquisa criou, imediatamente, a tendência do preprint (pré-publicação).
The Impact of DNA Methylation Dynamics on the Mutation Rate During Human Germline Development
Authors: Zhou Yijia , He Funan , Pu Weilin , Gu Xun , Wang Jiucun , Su Zhixi
Published: July 2020

DNA methylation is a dynamic epigenetic modification found in most eukaryotic genomes. It is known to lead to a high CpG to TpG mutation rate. However, the relationship between the methylation dynamics in germline development and the germline mutation rate remains unexplored. In this study, we used whole genome bisulfite sequencing (WGBS) data of cells at 13 stages of human germline development and rare variants from the 1000 Genome Project as proxies for germline mutations to investigate the correlation between dynamic methylation levels and germline mutation rates at different scales. At the single-site level, we found a significant correlation between methylation and the germline point mutation rate at CpG sites during germline developmental stages. Then we explored the mutability of methylation dynamics in all stages. Our results also showed a broad correlation between the regional methylation level and the rate of C > T mutation at CpG sites in all genomic regions, especially in intronic regions; a similar link was also seen at all chromosomal levels. Our findings indicate that the dynamic DNA methylome during human germline development has a broader mutational impact than is commonly assumed.
Phylogenomic Analyses of Non-Dikarya Fungi Supports Horizontal Gene Transfer Driving Diversification of Secondary Metabolism in the Amphibian Gastrointestinal Symbiont, Basidiobolus
Authors: Tabima Javier F , Trautman Ian A , Chang Ying , Wang Yan , Mondo Stephen , Kuo Alan , Salamov Asaf , Grigoriev Igor V , Stajich Jason E , Spatafora Joseph W
Published: July 2020

Research into secondary metabolism (SM) production by fungi has resulted in the discovery of diverse, biologically active compounds with significant medicinal applications. The fungi rich in SM production are taxonomically concentrated in the subkingdom Dikarya, which comprises the phyla Ascomycota and Basidiomycota. Here, we explore the potential for SM production in Mucoromycota and Zoopagomycota, two phyla of nonflagellated fungi that are not members of Dikarya, by predicting and identifying core genes and gene clusters involved in SM. The majority of non-Dikarya have few genes and gene clusters involved in SM production except for the amphibian gut symbionts in the genus Basidiobolus. Basidiobolus genomes exhibit an enrichment of SM genes involved in siderophore, surfactin-like, and terpene cyclase production, all these with evidence of constitutive gene expression. Gene expression and chemical assays also confirm that Basidiobolus has significant siderophore activity. The expansion of SMs in Basidiobolus are partially due to horizontal gene transfer from bacteria, likely as a consequence of its ecology as an amphibian gut endosymbiont.
Impacto do soco e do chute dos esportes de combate: uma revisão sistemática
Authors: Marques Junior Nelson Kautzner
Published: July 2020

O objetivo da revisão sistemática foi apresentar o impacto do soco e do chute de alguns esportes de combate. Os artigos foram identificados na internet durante setembro de 2018 a agosto de 2019. A coleta de artigos foi praticada no Google Scholar, no Research Gate e no PubMed. A revisão sistemática teve 19 artigos científicos. O maior impacto de soco do lutador masculino foi o direto do boxe com 4800±601 newtons (N). A lutadora do sexo feminino o maior impacto foi o jab do boxe com 1170,7±165,3 N. O impacto do chute no taekwondo feminino (TKD) teve um resultado maior do que tui tchagui com 2490,3 ± 846,2 N e no masculino teve um resultado de maior impacto do bandal tchagui do TKD de 6400 ± 898 N. Em conclusão, o impacto do soco e do chute dos esportes de combate é um conteúdo importante para o atleta conhecer o ataque mais eficaz.
IC & OI The impact of intellectual capital on organizational innovation
Authors: El-Gamal Fouad
Published: July 2020

Intellectual capital can generate value for organizations and improve organizational innovation. This study aims to investigate the effects of intellectual capital on corporate innovation. Mixed research methodology approach has been used by combining both qualitative and quantitative analysis to explore and empirical examine the research model. The targeted population of interest is the licensed pharmaceutical manufactures, 90 organizations in the Egyptian pharmaceutical industry throughout its three main sectors (11 public, 70 local private and 9 MNCs). Statistical analyses are employed based on the questionnaires gathered from 39 pharmaceutical manufactures’ companies (44% response rate). In addition, sixty-three “63” in depth interviews have been conducted with both top and middle managers. The research findings indicate that all dimensions of intellectual capital (human, structural, and relational capital) have positive significant effects on organizational innovation of pharmaceutical manufactures’ companies. The study clarifies that the most dominant dimension is structural capital, which provides the largest and strongest support to pharmaceutical manufactures’ companies. The deep realization of the importance intellectual capital and its impact on innovation helps leaders to adopt accurate system to run organizational innovation in a better way, which lead to sustainable competitive advantage for organizations.
Confirmation of the presence of Vanilla hartii Rolfe (Orchidaceae, Vanilloideae) in Brazil
Authors: Ferreira Alessandro Wagner Coelho , Pereira Franken Evelyn , Pansarin Emerson Ricardo
Published: July 2020

We confirm the occurrence of Vanilla hartii Rolfe in Brazil. This species was collected in FLONA Carajás, Amazonia, at the municipality of Parauapebas, state of Pará. This work contributes to the knowledge of the geographical distribution of this rare vanilla.
STATISTICAL PROCESSING OF BRAKE PADS WEAR PARAMETERS OF FREIGHT CARS
Authors: V. G. Ravlyuk  , M. G. Ravliuk  , I. K. Kirichenko
Published: July 2020

Purpose. This study is aimed at the statistical processing of the geometric parameters of pad wear of the modernized brake systems of freight cars` bogies. Methodology. A statistical approach to the construction of the graphical dependence of the brake pad wear on the car run was applied based on the previously collected wear data at checkpoints, which is regulated by the requirements of routine preventive repair. In this sense, theoretical and operational studies concerning the reduction of the non-standard wear of the brake pads were performed according to the regression analysis method based on the experimental data of the experimental operation of the upgraded devices of the brake systems of freight car bogies. The palliative approach to solution of this task is substantiated. Findings. It has been established that in practice there are cases when the pads do not provide their regulated run, as a result of which they are replaced prematurely for reasons of wedge-shaped wear. From the point of view of the economy and safety of their use, it leads to a decrease in brake efficiency in triangular brake systems. Experimental and scientific studies have found that when performing freight transportations plan, up to 95% of the car brake pads at standard braking devices have harmful double friction wear. This requires pads replacement in the warranty inter-repair period. It is established that during the inspection in the conditions of operation of brake shoe wear phenomena for the upgraded bogie devices based on the regression analysis, the prediction of the residual life of the pads was performed, the result of which is their use for the whole inter-repair period of freight cars. Originality. For the first time, the model of brake pad wear for upgraded devices of the bogie brake systems, depending on the car run, is adapted to build the regression dependence. Based on the results of the full-scale experiment, processing of the collected data on the pads wear in the absence of a normal law of statistical distribution was performed. Correspondence check of experimental and theoretical calculations according to the measurements of the pads wear was evaluated by Kochran's test. A «palliative» approach is proposed for statistical analysis regarding the wear of pads in the operating conditions, allowing to predict the residual life of the brake pads for their use for the whole inter-repair period of freight wagons operation. Practical value. The results of the studies were tested on experimental rolling stock with upgraded devices for uniform wear of brake pads in the bogies. A patent for an invention was obtained, which is recommended for implementation during the design of new and modernization of the existing brake systems for freight car bogies.
INVESTIGATION OF GEOMETRICAL DETERIORATION OF TRAMWAY TRACKS
Authors: Jover V. , Gaspar L. , Fischer S.
Published: July 2020

Purpose. The authors’ aim is to demonstrate their results of analysis of deterioration of tramway tracks’ geometry. Methodology. This article is a start of a PhD research. At first, the superstructure systems and the used instrument were summarized, after that the examination of running track, tramway stops, crossings and turnouts. Findings. The authors examined separately the running track, tramway stops, level crossings and turnouts. In case of examination of running track, we evaluated the measurement results according to two methods. To clarify the superstructure systems’ deterioration factor the authors had to do further measurements on other tramway lines too. Originality. The fulfilled analysis is the first step to the complex method that can consider and determine the optimisation of life-cycle costs of tramway superstructures. For this goal a lot of parameters, factors have to be taken into consideration in the future. There are available methods and models for different civil engineering areas, e.g. there is very complex methodology related to road pavements, but there is no special one related neither to railway tracks, nor tramway tracks. Practical value. The authors tried to construct a calculation and evaluation method that can assess the examined 6 different tramway superstructure types on the tramway line No. 1 in Hungarian capital (Budapest). It is a very new reconstructed tramway line that is the second longest one in Budapest. The authors showed which type of superstructure system is the «best» and the «worst» based on own made measurements and calculation-evaluation methods. The next aim of the authors is to start a PhD research in the Multidisciplinary Doctoral School at Szechenyi Istvan University (Győr, Hungary) with the continuation of this topic.
Diagonal compression testing of masonry panels with irregular texture strengthened with inorganic composites
Authors: Del Zoppo Marta , Di Ludovico Marco , Balsamo Alberto , Prota Andrea
Published: July 2020

Inorganic composites for enhancing the in-plane shear capacity of masonry walls with irregular texture were investigated on twenty-one panels under diagonal compression tests. Three specimens were used as control and twelve specimens were strengthened with two Fibre Reinforced Mortars (FRM-A and FRM-B), characterized by a different content of fibres embedded in the lime-based matrix. The remaining six specimens were strengthened with Fabric Reinforced Cementitious Mortars (FRCM), consisting in a GFRP grid embedded in a fibre reinforced matrix (the same used for FRM-A). The influence of single-side and double-side strengthening configurations on the capacity of strengthened panels was also investigated, to point out the reduction in strengthening effectiveness in case of single-sided applications. The results showed that all the inorganic composites adopted for the strengthening techniques provided a substantial increase of shear capacity. The grid in FRCM strengthened panels played an important role in both strength and deformation capacity at peak. The different fibres content (lower than 50% in weight) in FRM systems slightly affected the overall performance of panels. Finally, analytical predictions of experimental results were reported and discussed and a preliminary analytical model for estimating the FRM shear contribution was proposed, obtaining a good agreement with test results.
Environmental regulation and green productivity of the construction industry in China
Authors: Zhang Jingxiao , Pu Si , Philbin Simon P , Li Hui , Skitmore Martin , Ballesteros-Pérez Pablo
Published: July 2020

There are few studies analysing whether different types of environmental regulation have differential impacts on the efficiency of the construction industry. Using 2012–2016 panel data from 30 provinces in China, the green total factor productivity (GTFP) of the construction industry is measured with a global Malmquist–Luenberger productivity index based on the epsilon measure model. Thereafter, a panel tobit regression model is proposed to explore the relationship between three types of environmental regulation and the GTFP of the construction industry. The results show that (a) from 2012 to 2016, the GTFP of the Chinese construction industry grew slowly at an average annual rate of 0.14%; (b) both one-phase lagged command-and-control and current phase market-based environmental regulation had a positive linear relationship with GTFP, while one-phase lagged voluntary environmental regulation, on the other hand, had an inverted U-shaped relationship with GTFP; (c) the three types of environmental regulation can be combined to establish a suitable environmental regulation system. The findings of this study provide guidance for the sustainable development of the construction industry by combining the actions of different types of environmental regulation.
Scapuloperoneal Myopathy and Cardiomyopathy with a Novel MYH7 Mutation: A Case Report
Authors: Hooshmand Sara , Govindarajan Raghav
Published: July 2020

Introduction:

Myosin heavy chain 7 (MYH7)-related myopathies have variable clinical features and onsets and are emerging as a group of muscle diseases that affect a wide range of age groups. While individuals with (MYH7)-related myopathies will present with cardiac or skeletal involvement, it is less common to see cardiac and skeletal involvement occurring in a single individual. 

Case Report:

A 66-year old right-handed woman presented to the clinic for progressive ascending weakness, weight loss, and severe dysphagia. Symptoms first arose when the patient was in her 20s when she reported lower extremity weakness. Over the years, the weakness has ascended, and today the patient is unable to raise her arms. The patient has a family history of muscle disease, but testing has not been done. Neurological examination of mental status and cranial nerve were intact. Shoulder abduction, flexion, and extension was 2/5 bilaterally. Hip flexion was 3/5, and foot dorsiflexion was 2/5 bilaterally. There was no elevation of serum creatinine, and EMG showed myopathic process. Muscle biopsy of the deltoid revealed a myopathic changes with mini cores. EKG reveals first degree AV block with anterior ischemia and echocardiogram showing features of dilated cardiomyopathy. The genetic panel revealed c.4522_c.4524del (p.Glu1508del) resulting in pathogenic mutation of MYH7 leading to scapuloperoneal myopathy.

Discussion:

This case report illustrates the variability in clinical presentation of adult-onset MYH7 myopathy. MYH7 gene-related myopathies have notable clinical variability that can lead to the missed or late diagnosis of this progressive myopathy. While our case highlights the pertinent family history and co-existing cardiac involvement that is strongly associated with MYH7 related myopathy, it also illustrates further cases of MYH7 mutations causing both cardiac and skeletal muscle disease.
Myasthenia Gravis Mimicking Acute Cerebrovascular Events
Authors: Digala Lakshmi , Bailey Emily , Govindarajan Raghav
Published: July 2020

Background and Objective: Myasthenia gravis (MG) is an immune-mediated disorder that can sometimes present acutely with a focal neurological deficit and thus mimic a cerebrovascular event. The objective of this study was to describe the clinical characteristics in a large cohort of patients who were initially misdiagnosed with an acute vascular event and later diagnosed with MG.

Methods: This is a retrospective chart review of patients who were initially diagnosed with an acute cerebrovascular event but subsequently found to have MG. The chart review was done for the period from January 2013 to December 2017, and patients with at least one-year follow-up included.  Data are reported as means ± SEM, and the results reported using prevalence rates.

Results: Twenty-one patients met our inclusion criteria. Among them, 13 (61.9%) were female with a mean age of 56.7 ± 4.07 years. Ten were MGFA class 3a; seven were MGFA class 2b, 3 were MGFA 3b. Eighteen patients were acetylcholine receptor antibody positive; one was MuSK positive, and the rest two seronegative. Slurred speech (8 patients, 38.1%) was the most common symptom that resulted in misdiagnosis, followed by hemibody weakness (7 patients, 33.3%) and dysphagia (3, 14.3%). Smoking (12, 57.1%) and hypertension (11, 52.4%) were common risk factors for cerebrovascular disease. Small vessel disease was suspected the most common etiology (15, 71.4%) of the vascular event.  Ten patients had received thrombolytic therapy, and 16 patients were on antiplatelets. 4 patients who presented recurrent symptoms placed on anticoagulants.

Conclusion: Acute presentation of bulbar symptoms and hemibody weakness resulted in the misdiagnosis of MG.
Efficiency in Internal Auditing: A Study of Turkish Public Administration
Authors: Aydın Murat , TAYTAK Mustafa
Published: July 2020

With the development of the modern state approach, rational use of public resources has become particularly important for public institutions. In this context, the terms efficient, economical, and productive are considered important instruments in the effectiveness of public institutions. One of the necessary elements in the effectiveness of public institutions is the presence of an effective system of internal audit. The effectiveness of internal auditing generally depends on the existence of elements such as independence and impartiality of internal audits. In this study, internal audit perceptions of public servants who have financial responsibility were measured. Furthermore, the impact levels of elements that are effective in internal auditing were analyzed using the “Structural Equation Model.” This model showed that the high level of perception of value added to internal auditing is the most important factor affecting effective internal audits.
Industry 4.0-Related Digital Divide in Enterprises: An Analysis for The European Union-28
Authors: ATİK Hayriye , ÜNLÜ Fatma
Published: July 2020

Digital divide has been measured using various indicators in the literature so far. In contrast from the literature, this paper addresses the digital divide within European Union member states according to Industry 4.0-related indicators that have been used for the first time in empirical literature. While Finland, the UK and Germany are among the countries with economic development levels above the EU average, Cyprus, Bulgaria, and Romania are among the countries that are below the Union average in terms of Industry 4.0-related development. It is clear that an Industry 4.0-related digital divide is observable within EU member countries. The European Union should try to decrease the digital gap between member countries by developing and supporting special Industry 4.0 policies, especially for members below the EU average. Therefore, the results of this article will help policy makers in the EU and in member countries.
İhracata Dayalı Büyüme Hipotezinin Türkiye’de Bölgesel Düzeyde Test Edilmesi
Authors: KARA Mehmet Akif
Published: July 2020

İhracatın ekonomik büyümenin açıklanmasında kilit bir unsur olduğuna yönelik ihracata dayalı büyüme hipotezini test etmek amacıyla çeşitli ülkeler için çeşitli yöntemlere dayalı uygulamalı çalışmalar söz konusu iken, bu çalışma sonuçlarındaki farklılıklarda dikkati çekmektedir. Ancak bu çalışmaların büyük çoğunluğu ulusal düzeydedir. Türkiye ekonomisinde ihracata dayalı büyüme hipotezini bölgesel düzeyde test etmeyi amaçlayan bu çalışmada 2004-2017 Düzey-2 verileri Sistem-GMM yöntemiyle tahmin edilmiştir. Çalışma sonuçlarına göre, bölgesel ihracat bölgesel gelire pozitif katkı sağlamakta ve bu hipotez Türkiye’de bölgesel düzeyde desteklenmektedir.
Twitter ile Hisse Senetleri Oynaklığı Tahmin Edilebilir mi?
Authors: BOZMA Gürkan , KUL Sinan
Published: July 2020

Tweetlerin duygu analizi ile hisse senedi fiyat hareketleri arasında ilişki olduğu hatta hisse senedi fiyatlarının bu yolla tahmin edilebildiği yapılan çalışmalarla ortaya konmuştur. Tweetlerin, hisse senetlerinin oynaklığına etkisinin tahmin edilmesi üzerine yapılan bu çalışmada ayrıca, hisse senetlerinin birbirleri arasındaki ve duygu puanlarının hisse senetleri arasındaki oynaklık geçişkenlikleri de ortaya çıkarılmıştır. Çalışma kapsamında, ürünlerinin Türkiye’de satışı yapılan ve Borsa İstanbul’da faaliyet gösteren 3 telefon markası (Alcatel, Turkcell ve Vestel) hakkında paylaşılan Türkçe tweetler üzerinde Naive Bayes ile duygu analizi yapılmıştır. Analiz sonuçlarına göre Turkcell ve Vestel için elde edilen duygu puanlarının Arcatel’in koşullu varyansını istatistiki olarak anlamlı bir şekilde artırdığı tespit edilmiştir.
construct a taro linkage map using onemap v1
Authors: Michael Kantar not provided , Renee Bellinger M , Paudel Roshan
Published: July 2020

R script for taro linkage mapping using program onemap. This script was applied to create a linkage map for a taro mapping population resistant to taro leaf blight. The genotype file was constructed by calling SNPs using genotyping by sequencing data set using a taro genome reference genome available from NCBI's genbank under Bioproject PRJNA567267.
Olfactory Response as a Marker for Alzheimer’s Disease: Evidence from Perceptual and Frontal Oscillation Coherence Deficit v1
Authors: Javad Sedghizadeh Mohammad , Hojjati Hadi , Ezzatdoost Kiana , Aghajan Hamid , Vahabi Zahra , Tarighatnia Heliya
Published: July 2020

High-frequency oscillations of the frontal cortex are involved in functions of the brain that fuse processed data from different sensory modules or bind them with elements stored in the memory. These oscillations also provide inhibitory connections to neural circuits that perform lower-level processes. Deficit in the performance of these oscillations has been examined as a marker for Alzheimer’s disease (AD). Additionally, the neurodegenerative processes associated with AD, such as the deposition of amyloid-beta plaques, do not occur in a spatially homogeneous fashion and progress more prominently in the medial temporal lobe in the early stages of the disease. This region of the brain contains neural circuitry involved in olfactory perception. Several studies have suggested that olfactory deficit can be used as a marker for early diagnosis of AD. A quantitative assessment of the performance of the olfactory system can hence serve as a potential biomarker for Alzheimer's disease, offering a relatively convenient and inexpensive diagnosis method. This study examines the decline in the perception of olfactory stimuli and the deficit in the performance of high-frequency frontal oscillations in response to olfactory stimulation as markers for AD. Two measurement modalities are employed for assessing the olfactory performance: 1) An interactive smell identification test is used to sample the response to a sizable variety of odorants, and 2) Electrophysiological data are collected in an olfactory perception task with a pair of selected odorants in order to assess the connectivity of frontal cortex regions. Statistical analysis methods are used to assess the significance of selected features extracted from the recorded modalities as Alzheimer's biomarkers. Olfactory decline regressed to age in both healthy and mild AD groups are evaluated, and single- and multi-modal classifiers are also developed. The novel aspects of this study include: 1) Combining EEG response to olfactory stimulation with behavioral assessment of olfactory perception as a marker of AD, 2) Identification of odorants most significantly affected in mild AD patients, 3) Identification of odorants which are still adequately perceived by mild AD patients, 4) Analysis of the decline in the spatial coherence of different oscillatory bands in response to olfactory stimulation, and 5) Being the first study to quantitatively assess the performance of olfactory decline due to aging and AD in the Iranian population.
Total Nucleic Acids Extraction from Soil v5
Authors: Angel Roey , Petrova Eva , Lara-Rodriguez Ana
Published: July 2020

The following protocol is intended for the simultaneous extraction of DNA and RNA (total nucleic acids, or TNA) from various soil and sediment samples. The protocol was designed based on two protocols published by Henckel et al. (1999) and Griffiths et al. (2000), with several critical modifications. Recently, we have added option to include an ammonium aluminium sulfate salt for soils with high humic content (Braid et al., 2003). The result is a highly flexible and streamlined protocol, which delivers high yields of nucleic acids with quality suitable for all downstream molecular applications from most types of soil and sediment samples. Please cite Angel et al. (2012).
A step by step guide to using Visual Field Analysis v1
Authors: Josserand Mathilde , S Lemaire Bastien
Published: July 2020

In this protocol, we provide a step by step guide to using Visual Field Analysis (VFA) successfully. VFA is a python program based on DeepLabCut toolbox (Nath et al., 2019). Using our program, it is possible to score reliably the eye use, activity, and time spent in different zones of different animal species and experimental paradigms for more reproducible research.
16S Bacteria 338F-516P-805R BSA v1
Authors: Angel Roey , Petrova Eva
Published: July 2020

Universal 16S rRNA probe-based-qPCR assay for bacteria. The primers and probe are taken from Yu et al. (2005).
A Formação docente e suas implicações na inclusão escolar
Authors: Nunes Camila da Cunha , Manrich Nadine , Alexssandra Vailate Fidelis Amanda
Published: July 2020

Este estudo objetiva analisar a percepção de professores (regentes e auxiliares) da Rede Pública de Ensino do município de Brusque – SC sobre a inclusão de estudantes que apresentam algum tipo de deficiência, mental, física, visual ou auditiva. Para tanto, foi realizada uma pesquisa qualitativa de caráter exploratório e documental, com entrevista semiestruturada e observação livre. A amostra foi composta por cinco professores (regentes e auxiliares) que ministravam aulas para turmas que possuíam estudantes com deficiência. Os resultados indicam que a formação propiciada durante a graduação contribui para se (re)pensar atitudes, mas, por ser insuficiente, não oportuniza mudanças de fato efetivas na prática pedagógica. Existe, portanto, uma necessidade de articular teoria e prática pedagógica, e uma das possibilidades poderia ser a realização de estágios supervisionados norteados pelas demandas e por propostas de inclusão, além da ampliação da oferta de disciplinas que estimulem a articulação entre o conhecimento científico e as práticas de inclusão.
Potencial Alelopático de Espécies da Família Fabaceae Lindl
Authors: Oliveira Ykaro Richard , Silva Paulo Henrique da , Abreu Maria Carolina de , Leal Cledinaldo Borges , Oliveira Lauana Pereira de
Published: July 2020

O objetivo deste artigo foi realizar uma pesquisa de caráter bibliográfico acerca dos estudos desenvolvidos com representantes da família Fabaceae e destacar quais efeitos alelopáticos tais espécies desempenharam sobre outras plantas. Foram listadas 24 espécies de Fabaceae, sendo o gênero Anadenanthera o mais representativo neste artigo, com três espécies estudadas. A partir da análise dos arquivos, foi evidenciado que os representantes da família Fabaceae investigados apresentam em sua composição química substâncias responsáveis por gerar um efeito alelopático sobre outras espécies, caracterizando, dessa forma, uma função ecológica desses vegetais para a constituição dos ecossistemas em que se incluem. Além disso, tal característica pode despontar uma provável utilização desses seres no controle de plantas daninhas, que representam um grande problema para os agricultores. Também foram percebidos com maior frequência estudos voltados ao uso de bioensaios laboratoriais com o uso da espécie Lactuca sativa, noticiando a carência de estudos mais complexos sobre a ação dos aleloquímicos, quando lançados em condições naturais no ambiente.  

Palavras-chave: Aleloquímicos. Germinação de Sementes. Leguminosae.

 

Abstract

The objective of this paper was to perform a bibliographic research about the studies carried out with representatives of the Fabaceae family and stress out what  allelopathic effects such species develop on other plants. Twenty-four Fabaceae species were listed, being the Anadenanthera genus the most representative in this article, with three species studied. It was noticed in the studies analysis that certain Fabaceae species contain  in their chemical composition, substances responsible for an allelopathic effect on other species, characterizing an ecological role of these plants for the  ecosystems establishment. This feature can suggest the use of these species in weed control, which represent a problem to farmers. It was seen more often studies focused on the use of laboratory bioassays with Lactuca sativa, reporting the lack of more complex studies on the action of allelochemicals when launched in natural conditions in the environment.

Keywords: Allelochemicals. Seed Germination. Leguminosae.
Литературные и литературно-юмористические журналы в лагерях интернированных воинов Армии УНР в Польше (1921 – 1923 гг.): тематическая наполненность и специфика издания
Authors: Holubnycha-Shlenchak Yuliia
Published: July 2020

Tematem artykułu jest jakościowa i ilościowa charakterystyka czasopism, wydawanych przez internowanych Ukraińców w polskich obozach w latach 1921–1923. Przebywający w trudnych warunkach oficerowie i żołnierze Armii URL potrzebowali zarówno wsparcia psychicznego, jak i informacji o sytuacji panującej w pozostałych obozach. Zadanie to z powodzeniem wypełniały liczne wydawnictwa ciągłe. Jednym z rodzajów były czasopisma literackie i humorystyczne. Tego typu wydania zawierały utwory literackie, wiersze, opowiadania, sztuki teatralne, wspomnienia żołnierzy, omówienia i recenzje, humoreski, anegdoty i inne. Artykuł jest oparty na źródłach archiwalnych, prasie obozowej oraz pracach historyków polskich i ukraińskich.
MICROPLASTICS IN OUR PLANET: SOURCE, DISTRIBUTION, EFFECTS AND BIODEGRADATION
Authors: AHAMADA RACHID Nahdhoit , DOĞRUÖZ GÜNGÖR Nihal
Published: July 2020

In this last decade, the environmental problems of microplastics have been occupied a large place in the world scientific researches. The unbreakable property of these particles causes their rapid accumulation in the environment. Their micro and millimetric sizes let them to be distributed over the world in a way almost uncontrollable. Works are still multiplying in identification of the source and nature, in the fate and effects of the microplastics on the different ecosystems. The accumulation of these debris in our ecosystem is a serious problem in the way of their distribution and migration: from the aquatic to the terrestrial ecosystem, all food web class will be affected. Different solutions for escaping their over distribution in the world have been studied. However, the biodegradation of this tiny particles seems the perfect solution of their disappearance from our environments. Studies seem slowly progressed because of different types of microplastics and the unknown mechanism of most of microorganisms on the surface of microplastics. This review is a synthesis of works done in microplastics by offering a good comprehension in microplastics source, effects and biodegradation both in aquatic and terrestrial ecosystems. Researchers will have to expand their working fields by approaching to the extreme ecosystems such as caves in the hope of finding microorganisms capable of producing enzymes that will serve in a complete degradation of these debris.
“Just a Job?” An Assessment of Precarious Employment Trajectories by Gender Among Young People in the U.S.
Authors: Allmang Skye , Franke Todd
Published: July 2020

Precarious employment is on the rise in the United States. Research suggests that young workers are more likely than older workers to be in precarious work. Yet much remains unknown regarding the precarious nature of employment experienced by young workers, despite evidence of the importance of this period for long-term employment opportunities. To address this gap in knowledge, this study used a nationally-representative, longitudinal dataset to create a multi-dimensional measure of precarious employment, and assessed precarious employment trajectories over time for young women and men. Findings revealed that, while there were significant shifts in levels of precarity over time for both males and females, patterns differed by gender. Overall, higher percentages of females than males remained concentrated at the semi-precarious level over time—meaning that they did not move further into or out of precarious employment—while higher percentages of males became either much more precarious or much less precarious over time. These findings challenge the common assumption that young people generally move out of low-wage or otherwise “bad” jobs over time, and suggest that there is a need for additional attention to gendered patterns in job quality among young people. Social workers have an important role to play in helping young people enter non-precarious jobs, and in engaging in advocacy to improve the quality of jobs available.