bluuebunny/crossref_metadata_2025 huggingface dataset:
An Updated Overview of Non-Dairy Probiotic Beverages
Authors: Kilci Zeynep
Published: March 2023

Recently, there has been increased interest in the adoption of healthy diets that aid in disease prevention, and as a result, the research and development of new functional foods has gained great importance. Food additives such as probiotics and prebiotics can have positive effects on the composition of the gut microbiota and have therefore been the subject of intense research for a long time. There are many studies with the positive opinions of health professionals on the positive effects of adding beneficial microorganisms to food in live form and consuming these foods on health. Both economic and health reasons have triggered the search for alternative matrices other than milk for probiotic microorganisms. In particular, individuals who have health problems such as lactose intolerance and milk protein allergy experience various problems when they consume fermented milk and products. In addition, consumers who have ethical concerns about the environment and animal rights in developed countries are turning to vegetarian diets. All these reasons and factors combined encourage the idea of reducing the use of dairy ingredients as vehicles for probiotic agents. It is predicted that beverages such as fruit and vegetable juices or grain-based beverages will be the next food research category to be dominated by healthy probiotic bacteria in the near future. Within the scope of this information, it is aimed to make a general evaluation of some non-dairy probiotic beverages in this study.
Investigation of the Effects of Different Cooling/Lubrication Conditions and Cutting Parameters on Energy Consumption During Milling of Hybrid Aluminum Composites
Authors: Değirmenci Ünal
Published: March 2023

In the developing technological world, energy consumption is increasing day by day. Reducing energy consumption on a sectoral basis is very important for sustainable resource use and the improvement of environmental health. The manufacturing sector is one of the sectors where energy consumption is intense. Therefore, even a small improvement in the energy consumption in the machining sector will significantly affect the overall energy consumption, costs, and environmental performance of production systems. Since hybrid aluminum metal matrix composites (AMMC) are difficult to process due to their complex microstructure, energy consumption values during processing are high. For this reason, it is important to determine the most appropriate values by examining the cutting parameters and cooling lubrication conditions during processing to reduce energy consumption. In this article, Al-Gr reinforced hybrid composites containing different proportions of WC and Al2O3 reinforcements were produced. The focus is on the energy consumption when milling these composites under different cooling/lubrication conditions and different machinability parameters such as the dry, minimum amount of lubrication (MQL), and cryogenic-LN2. Taguchi statistical analysis was also used in the experiments. As a result, it was determined that the most effective parameter on the energy consumption values among the control parameters was the feed rate, with a contribution rate of 75.37%. In addition, for minimum energy consumption values, it was observed that the best cutting speed was 150 m/min, the best feed rate was 0.300 mm/rev, and the best cooling/lubrication medium was cryo-LN2 cooling medium.
Digital Twin in Agriculture
Authors: Durgun Mahmut
Published: March 2023

The agricultural sector is a fundamental sector for meeting the nutritional needs of people and is the livelihood of many people around the world. However, the agricultural sector, like other sectors, needs development. With the rapid development of technology, the use of digital technologies in the agricultural sector is also increasing. These technologies are used to increase the productivity of the agricultural sector, to ensure sustainability and to reduce costs. Digital twin technology is among these technologies. Digital twin technology is the creation of a virtual copy of a real object. This technology can be used in many areas such as plants, animals, land and production in the agricultural sector. The innovations brought by this technology to the agricultural sector have been the subject of many academic studies. In this article, the innovations brought by digital twin technology in agriculture in terms of plants, animals, land and production will be discussed and the results of academic studies will be included.
İpek Yolunun Yeniden Canlandırılması: Teorik Zorluklar ve Politika Uygulamaları
Authors: Çetin Canan
Published: March 2023

Mackinder tarafından 'Dünyanın Kalbi' olarak adlandırılan Orta Asya, dünyanın güç dinamikleri üzerinde önemli bir etkiye sahiptir. Eski İpek Yolu'nun yeniden canlandırılması avantajıyla Rusya, Amerika Birleşik Devletleri, Avrupa Birliği, Çin ve Türkiye, karmaşık karşılıklı bağımlılık çerçevesindeki politika çıkarımlarıyla farklı sonuçlara sahiptir. Devletlerin farklı pazarlık güçleri, kırılganlıkları ve amaçları nedeniyle her güç bölgeye farklı bir şekilde odaklanmıştır. Dolayısıyla bu çalışma, İpek Yolu'nun yeniden canlandırılması yoluyla bölgedeki güç dinamiklerini karmaşık karşılıklı bağımlılık kavramı üzerinde analiz etmeyi amaçlamaktadır. Seçilen makaleler ve dergiler içinde, teorik çerçeve için literatür taramaları ve politika çıkarımları için politika belgeleri analizi derinleştirmek için kullanılır. Bunu yapmak için, karmaşık karşılıklı bağımlılık modeli, ekonomik boyut, enerji güvenliği bölümü ve insan hakları ve demokratikleşme konuları gibi bölge üzerindeki politika sonuçlarını açıklamak için üç farklı açıdan analiz edilecektir.
Tarihi Perspektifte İnovasyondan Günümüz İnovatif Okuryazarlığına
Authors: Yüksel Asiye
Published: March 2023

İnovasyon bugün her yerde karşımıza çıkmaktadır. Kuruluşlar beyanlarında inovasyon terimini kullanmakta, politikacılar ko-nuşmalarında düzenli olarak inovasyon teriminden bahsetmekte-dir. İnovasyonun ne olup ne olmadığını belirlemek için öncelikle onu tanımlamak önemlidir. İnovasyonun günümüzdeki tanımla-rına geçmeden anlam yolculuğunu gözden geçirmek güncel san-dığımız kavramın önemini daha pekiştirecektir. Kavramın tarihsel yolculuğuna bakıldığında anlamının negatiften pozitife yol aldı-ğını söylemek doğru olacaktır. Bu bölümde inovasyonun anlam-sal yolcuğu tarihi perspektiften ele alınarak günümüzde ulaştığı manaya dair literatürel bir analiz yapılmıştır. Kavramın anlamının hem kelimesel hem de bilimsel anlamdaçok geliştiği görülmüştür.
Establishing a standard-basis for the characterization of marine microp lastic-pellets
Authors: Almeida Clara Cabral , Cavalcante Willame de Araújo , Brito Camila Dourado Alves , Silva Lucas Nogueira Guerra , Bochow Mathias , Santaella Sandra Tédde
Published: March 2023

Plastic pellets are small granulated microplastics (diameter ranging from 1-5 mm), which are considered as emerging pollutant in aquatic environment. Currently, the literature provides a poor database for classification and standardization of plastic pellets, impairing the comparison of environmental impacts assessed by several studies. Thus, in this work, a classification related to pellet characteristics was proposed in order to establish a standard of identification. Four sampling surveys were carried out in the Pecém-CE port area in the year of 2017 (northeastern coast of Brazil). The pellets were characterized according to its size, shape, transparency, and color. From the characterization of the 1,411 pellets collected, granules with different morphologies were observed. Most classes of pellets had light colors (white 37%, yellow 22% and amber 12%). The classification of the granules resulted in a catalog with 155 classes, divided into four blocks. The standardization of the characteristics of the pellets in classes, provided a documentation of the types of granules produced and found near the port area, making it possible to quantify and characterize the granules manually and with the naked eye. This type of classification can be used anywhere in the world as a tool to assist research on the presence of pellets in the marine environment and the impacts caused by them.
Interview | African Water Cities: Embedding Local Knowledge for Sustainable Coexistence between Humanity and the Environment
Authors: Donkor Carlien , D'Agostino Matteo
Published: March 2023

This interview highlights the extensive research project African Water Cities by architectural studio NLÉ, which explores intersections of rapid urbanization and climate change in the African context. NLÉ proposes new strategies for addressing water, culture and heritage management in Africa as Sub-Saharan Africa experiences the second-fastest rates of urbanization and population growth in the world. The discussion also addresses whether and how these strategies fit within the scope of the UN SDGs.
Indirect somatic embryogenesis in sweet orange cv. “Mosambi”
Authors: Prusty Reena , Awasthi O. P. , Singh S.K. , Bharadwaj C.
Published: March 2023

This study was carried out for standardization of a reliable protocol by using different explants (epicotyl,cotyledon, and root), plant bioregulators (PBRs), and carbon sources on indirect embryogenesis during 2019-2022. Among the treatments tested, T4 (MS + 2,4-D (1.5 mg L-1) + BAP (1.0 mg L-1) + ME (500 mg L-1)) proved bestfor callusing (90.89 %), callus fresh weight (0.83 g), turgid weight (0.84 g) and dry weight (0.08 g) as comparedto others. In terms of callusing (83.72%), callus fresh weight (0.67 g), turgid weight (0.68 g), dry weight (0.05g) and callus water content (11.28 %), explants epicotyl (E) showed its superiority over others. Similarly, thetreatment combination T4 × E surpassed others in callusing potential. Embryogenesis (59.09%) and germination(33.61%) were best in T7 (MS + BAP (2 mg L-1) + NAA (0.1 mg L-1) + ME (500 mg L-1)). Among the different carbonsources, 5% glycerol supplemented with T7 proved best in inducing the highest number of somatic embryos/callus mass (73.26), embryogenesis (65.27%), and plantlet formation (68.77%). The standardized protocol canbe used for indirect embryogenesis for different genotypes of sweet orange.
"TECHNISCHES DEUTSCH FÜR STUDIERENDE. ENTWICKLUNG VON SPRACHKOMPETENZEN"
Authors:   Politehnica University Timişoara, Dejica-Carțiș Anca
Published: March 2023

Aktuelle Tendenzen im Fremdsprachenunterricht assoziieren die Sprachkompetenzen mit kommunikativen Fähigkeiten, mit Fachwissen und mit der Fachsprache. Sprachkompetenzen sind Fähigkeiten, die kognitive, lexikalische und soziolinguistische Kompetenzen erweitern. Man unterscheidet im Curriculum für Fremdsprachen nicht nur alltäglich-kommunikative Kompetenzen, sondern auch fachlich-kommunikative Kompetenzen. Der Fremdsprachenunterricht ist diesbezüglich von wesentlichen Themen aus dem Studienbereich begleitet. Technisches Deutsch ist sowohl auf regionaler als auch auf nationaler Ebene notwendig. Das setzt zukünftige Ingenieure in der Position sich mit Fachbegriffen und Themen aus dem beruflichen Umfeld auseinanderzusetzen, um kommunikative Sprachkompetenzen zu beweisen.
"STRATEGIES EFFICACES POUR BIEN INTERPRETER LES EXPRESSIONS FORMELLES "
Authors:   Lucian Blaga University of Sibiu, Nechita Maria Larisa , Milcu Maria Elena ,   Lucian Blaga University of Sibiu
Published: March 2023

https://dspace.upt.ro/jspui/handle/123456789/5328#:~:text=L%E2%80%99interpr%C3%A9tation%20de%20conf%C3%A9rence,les%20diff%C3%A9rences%20culturelles.
CRITICAL THINKING, ACTIVISM AND APPLIED ETHICS
Authors:   Politehnica University Timişoara, Băiaș Cosmin-Constantin
Published: March 2023

Critical thinking as attitude and current activity is a practice of everyday argumentation. At the same time, critical thinking is a tool for training young people in a democratic society. It is a modality of education in the spirit of individual freedom. We are in favor of choosing some critical themes for which the researcher has a strong implication. The analysis and evaluation of arguments often leads to positive effects insofar as the neutral researcher turns into an informed activist. We argue that the subjects of applied ethics can be an excellent framework of analysis in which critical thinking skills can be developed both for the benefit of the individual and for the benefit of contemporary society.
Optimalisasi Kewenangan Desa dalam Pembangunan dan Kesejahteraan Masyarakat Desa Dongko Melalui Legislasi Desa
Authors: Muhammad Daffa Arya Wardhana  , Muhammad Rizqi Hilal Ilham Ramadhan  , Yana Indawati
Published: March 2023

Kewenangan di desa mencakup kekuasaan yang didelegasikan dari tingkat pemerintahan yang lebih tinggi (seperti tingkat federal, provinsi, atau kabupaten/kota) dan kekuasaan berdasarkan hak asal usul tradisional dan kewenangan lokal di tingkat desa. Menurut Undang-Undang Nomor 6 Tahun 2014 tentang Desa, desa merupakan badan hukum tersendiri yang memiliki wilayah hukum, tugas, dan perlindungan tersendiri. Negara Kesatuan Republik Indonesia memberikan unit wilayah terkecil, desa, otonomi penuh di bawah kerangka hukum dan peraturan yang mengatur negara. Oleh karena itu, desa memiliki pemerintahan sendiri dalam hal mengatur urusan pemerintahan, melaksanakan hak dan kewajiban desa melalui penyelarasan kelembagaan desa dan kelompok masyarakat dengan kepentingan dan masyarakat desa, serta menjalankan kewenangan desa untuk pembangunan dan kesejahteraan masyarakat desa.
Pelatihan Media Terbarukan Berbasis Virtual Reality Bagi Tenaga Kependidikan, Laboran dan Pustakawan di SMPN 3 Mranggen Demak
Authors: Siti Kholifah  , Achmad Buchori
Published: March 2023

Tahun 2022 merupakan era perubahan yang besar dan mendadak karena pandemic Covid-19. Sektor pendidikan mengalami dampaknya. Salah satu solusi bagi tenaga kependidikan dalam mempromosikan sekolahnya dan paraktek di laboratoratorium atau perpustakaan adalah dengan menggunakan teknologi Virtual Reality sebagai media alternatifnya. Dengan memanfaatkan media Virtual Reality ini, tentu akan membuat pembelajaran dan pelayanan akademik lebih menarik, inovatif, dan memberikan imajinasi lebih baik bagi siswa dalam belajar baik pada waktu jam belajar atau diluar jam belajar. Tentu saja kombinasi-kombinasi kegiatan lanjut dengan pemanfaatan media ini perlu disiapkan oleh karyawan atau tenaga kependidikan.

Kegiatan Pengabdian Kepada Masyarakat (PKM) ini bertujuan untuk; (1) memberikan pengenalan kepada tenaga kependidikan di SMPN 3 Mranggen mengenai media Virtual Reality sebagai alternative media pembelajaran, media promosi sekolah, media perpustakaan, dan (2) melatih tenaga kependidikan SMPN 3 Mranggen untuk mampu memanfaatkan media terbarukan di laboratorium, Tata Usaha maupun perpustakaan. Metode yang diterapkan dalam program pengabdian ini, yaitu metode presentasi, metode demonstrasi, dan metode praktik. Metode presentasi diterapkan dalam pengenalan software hypermedia menggunakan aplikasi millealab, kemanfaataannya, dan penerapannya dalam pembuatan media berbasis virtual reality, metode demonstrasi mengenai pengoperasionalisasian program dan metode praktik dimana tenaga kependidikan mempraktikkan secara langsung pembuatan media pembelajaran sesuai kebutuhan masing-masing dengan pemanfaatan media berbasis virtual reality.
Caracterização morfométrica das micro bacias hidrográficas inseridas no município e Itaporanga (PB)
Authors: Peruzzo Jeremias de Sousa , Silvino Guttemberg da Silva , Araújo Maria Cristina Pereira de , Leon Mauricio Javier de , Arruda Filho Nivaldo Timóteo de , Lisboa Fabiana Donato Soares
Published: March 2023

Este trabalho teve como objetivo realizar a Caracterização Morfométrica das microbacias hidrográficas do rio Piancó inseridas no município de Itaporanga-PB com auxílio de um Sistema de Informação Geográfica, no sentido de gerar uma base de dados para o planejamento ambiental, permitindo o estabelecimento de diretrizes para projetos e implantação de políticas públicas municipais. A base de dados utilizada foi obtida através de imagens SRTM disponibilizadas pela NASA, o processamento e gerenciamento dos dados foram realizados em um ambiente de SIG de uso livre (QGIS v 3.16). Na área de estudo foram delimitadas 19 (dezenove) micro bacias hidrográficas onde as áreas das mesmas variaram de 4,12 km² a 65,92 Km². Para a relação de relevo foi obtido uma média de 127,51 m/km, fator que tende a favorecer escoamento rápido. No que diz respeito a forma da bacia, fator primordial a possíveis enchentes, destacam-se, a saber, o coeficiente de compacidade (Kc) que teve variação entre 1,22 e 1,70 com valor médio de 1,52; o índice de circularidade (Ic) variando entre 0,32 a 0,66 com valor médio de 0,44; o fator de forma (Kf) variando entre 0,18 a 0,76 com uma média de 0,37. Em relação a densidade hidrográfica das microbacias, a área de estudo apresentou uma média de 3,22 canais/km². Outro fator de relevância calculado foi a densidade de drenagem que variou de 1,46 a 1,91 km/ km², ficando com uma média de 1,66 km/ km².
Evaluation of a residential project in light steel framing according to leed for homes
Authors: Morselli Luiza Beatriz Gamboa Araújo , Knop Stífany , Faria Osvaldo Luis Vieira , Quadro Maurízio Silveira , Andreazza Robson
Published: March 2023

The construction industry is responsible for high energy consumption, high carbon dioxide emissions, high extraction of non-renewable materials, and large generation of solid waste in the world. The use of prefabricated, industrialized, and technological construction methods can reduce environmental impacts generated. Aiming to confirm its environmental benefits, the research proposal was to analyze the sustainability of a residential project in Light Steel Framing (LSF), according to the requirements of the environmental certification Leadership in Energy and Environmental Design (LEED) for Homes of the Green Building Council (GBC) Brazil Homes. For this, it was necessary to apply the Technical Quality Regulation for the Energy Efficiency Level for Homes, achieving the A-level classification in this analysis, with 5.06 final points. Therefore, it was considered the constitution of the building wrap in LSF, the energy efficiency of the materials used, the water heating and lighting systems. In order to obtain the highest level of LEED certification, the project has received suggestions for improvements. The project obtained 60 final points in the analysis, which would allow the achievement of the gold certification seal. The total score in the Materials and Resources topic demonstrates the great benefit of the system in LSF in environmental preservation.
Potencial biotecnológico de Chromobacterium subtsugae: uma breve revisão voltada ao manejo biológico de artrópodes-praga
Authors: Cavalcante Jéssica Karina Guedes , Conte Helio , Daquila Bruno Vinicius , Caleffe Ronaldo Roberto Tait
Published: March 2023

Chromobacterium subtsugae é uma bactéria gram-negativa que vem sendo utilizada na agricultura, nos últimos anos, no manejo de diversas espécies de artrópodes-pragas, devido aos seus metabólitos tóxicos. Apesar de avanços na sua utilização, são escassas as informações acerca de sua patogenicidade no Brasil. Desse modo, a presente revisão bibliográfica objetiva compilar os dados mais recentes (2011-2021) sobre as características gerais de C. subtsugae, seu modo de ação e os resultados no manejo biológico de diferentes artrópodes-praga. O levantamento bibliográfico foi realizado nas plataformas Google Scholar, Periódicos Capes e Science Direct, com um filtro para o período de 2011-2021, utilizando a combinação de palavras: Chromobacterium subtsugae, bactéria entomopatogênica (entomopathogenic bacteria) e controle biológico (biological control). C. subtsugae evidencia vários efeitos em insetos-praga como toxicidade oral, repelência, redução da fecundidade em fêmeas e oviposição e, inibição da alimentação em indivíduos das ordens Hemiptera, Thysanoptera, Coleoptera, Diptera e Acari (ácaros fitófagos), sendo seu mecanismo de ação considerado complexo, podendo sintetizar no decurso da fermentação, três fatores inseticidas: cromamida A, violaceína e um composto não identificado. Perante tais elucidações, constata-se a importância da referida bactéria no desenvolvimento de novos produtos direcionados ao manejo de diversos insetos-praga, principalmente, pelo seu amplo espectro de ação. Ademais, espera-se que os dados levantados sirvam de referencial para pesquisas futuras com C. subtsugae, tanto em experimentos em campo quanto laboratoriais no Brasil, posto que não há inseticida comercial contendo a referida bactéria como ingrediente ativo.
Uso sustentável da cinza de eucalipto no cultivo de Beta vulgaris
Authors: Margonar Gabriela Magdalena Sartorelli da Silva , Paccola Edneia Aparecida de Souza , Gasparotto Francielli , Schmidt Filho Edison , Santos Fabiana Maestá dos
Published: March 2023

A preocupação com a origem e o modo de produção agrícola sustentável tem despertado interesse na realização de pesquisas com produtos oriundos da agroindústria, que gera grande volume de resíduos orgânicos. A cinza produzida pelos processos agroindustriais é um destes resíduos, estimando que sua produção mundial seja de 750 milhões de toneladas por ano e apenas metade deste volume tem reutilização de uma forma sustentável. O objetivo deste trabalho foi analisar a interação da cinza de cavaco de eucalipto em solo argiloso e arenoso através da análise química e avaliar o desenvolvimento da beterraba sob diferentes dosagens de cinza. O delineamento experimental foi realizado em blocos inteiramente casualizados, com arranjo fatorial de 2X6, sendo dois tipos de solo e seis tratamentos, tendo sete repetições cada arranjo. Os atributos físicos e químicos dos dois solos e da cinza de eucalipto foram avaliados. As variáveis analisadas foram números de folhas, diâmetro da raiz, comprimento da raiz, massa verde da parte aérea, massa seca da parte aérea, massa verde da raiz, massa seca da raiz de beterraba. Os resultados foram submetidos a análise de variância (5%) , ao teste de Tukey (5%) e teste de regressão de probabilidade a 5%. A cinza utilizada apresentou quantidade razoável de nitrogênio (N) e cálcio (Ca) e apenas traços de magnésio (Mg), com alta relação Ca/Mg e pH alcalino. Observou-se um aumento nos teores dos nutrientes no solo, assim como reduziu a disponibilidade de alumínio, elevando o pH, deixando os nutrientes essenciais em melhor disponibilidade para serem absorvidos no sistema radicular da planta. Os teores de MO, P, K, Ca, Mg no solo elevaram-se, de acordo com o aumento das doses aplicadas, melhorando o pH, CTC, SB e V%, proporcionando melhor desenvolvimento do sistema radicular e da parte aérea da planta de beterraba. O solo argiloso foi o que demonstrou melhores respostas com a incorporação da cinza vegetal, tanto nas características químicas do solo, quanto no desenvolvimento da beterraba. Os resultados indicaram que a cinza vegetal como corretivo e fertilizante melhora as características químicas do solo. A dose de cinza vegetal que proporcionou melhores características biométricas e acarretou em maior produção de beterraba foi de 28 g/dm3. O fornecimento de cinzas no solo contribuiu para o desenvolvimento destas raízes.
Teores de macro e micronutrientes em plantas de jambu cultivadas em ambiente protegido
Authors: Emerique Camila Borges de Lima , Lima Luana Cruz , Carmo Andreza Sousa , Lima Michelane Silva Santos , Carvalho Felipe Souza , Ponce Franciely da Silva , Alves Gustavo Antonio Ruffeil , Borges Luciana da Silva
Published: March 2023

A importância da quantificação dos nutrientes acumulados nas plantas se dá para avaliar a real necessidade da planta realizando as recomendações de adubação de maneira adequada. Com o objetivo de avaliar os teores de macro e micronutrientes na cultura do jambu cultivado em ambiente protegido, bem como quantificar sua necessidade em relação aos elementos ao longo do seu ciclo. Os experimentos foram conduzidos em ambiente protegido na área experimental de horticultura da Universidade Federal Rural da Amazônia, campus Paragominas/PA, no período de fevereiro a março de 2016. Utilizou-se o delineamento experimental inteiramente casualizados. Para obtenção das amostras, inicialmente foi realizada a semeadura, em bandeja de polietileno expandido de 128 células contendo o substrato comercial Turfa fértil, em seguida as bandejas foram levadas para o viveiro, após 24 dias foi realizado o transplante manual das mudas de jambu ao qual foram utilizados 25 vasos de polietileno que foram totalmente preenchidos com substrato obtido de uma mistura de Latossolo Amarelo (50%) e areia preta (50%), ambos foram peneirados e incorporados junto à 50g NPK (10-28-20). O jambu cultivado em ambiente protegido responde como as demais hortaliças em relação a níveis de exigência nutricional em folha demonstrando os teores em ordem decrescente de concentração: K > N > Ca > Mg > P > S, diferentemente da raiz onde foram encontrados na seguinte ordem: K > Mg > N > Ca > P > S. O nutriente encontrado em concentrações expressivamente maiores foi o K, atingindo o pico nos 24 DAT com as concentrações de 90 g/kg. Já os micronutrientes apresentaram-se diferentemente em relação aos níveis de exigência nutricional, apresentando na folha: Fe > Na > B > Mn > Zn > Cu, e na raiz Fe >Na > Mn > B > Zn > Cu. O Fe oscilou os valores dos teores de acúmulo, mas no geral mantém resultados maiores que 600 mg/kg.
Molecular docking and dynamics simulation analysis of the human FXIIa with compounds from the Mcule database
Authors: Odhar Hasanain Abdulhameed
Published: March 2023

The human factor XIIa is a serine protease enzyme that is implicated in the pathological thrombosis. This coagulation factor represents an interesting molecular target to design safer antithrombotic agents without adversely influencing physiological hemostasis. Therefore, it is of interest to virtually screen the human factor XIIa crystal with millions of compounds in Mcule database in order to identify potential inhibitors. For this purpose, both molecular docking and dynamics simulation were employed to identify potential hits. Also, various predictive approaches were utilized to estimate chemical, pharmacokinetics and toxicological features for the top hits. As such, we report here that compound 4 (1‐(4‐benzylpiperazin‐1‐yl)‐2‐[5‐(3,5‐dimethylpyrazol‐1‐yl)‐1,2,3,4‐tetrazol‐2‐yl]ethanone) may be a potential ligand against the human factor XIIa for further consideration in the design and development of novel antithrombotic agents.
Oral Streptococcus mutans load among Indian children with cerebral palsy
Authors: Gandhi Aniruddh
Published: March 2023

The motor impairments of cerebral palsy (CP) are typically accompanied by subsequent musculoskeletal issues, seizures, and abnormalities of sensation, intelligence, communication, and behaviour. These kids have a lower capacity for regulating oral health because of their poor voluntary movements. Poor oral hygiene brought on by insufficient brushing and flossing, increased use of sugary foods, and orally administered drugs puts people at risk for periodontal disorders and dental caries. Poor dental health and rising therapy demands establish a sadistic cycle that affects patient overall health and wellbeing. The purpose of this investigation was comparing kids with CP against healthy kids of comparable age group and demographic situation in order to evaluate status of oral heath, current caries behavior using measurement of Streptococcus mutans concentrations in saliva, and treatment required. 204 study participants were divided into two categories: Category A and category B. Both categories consisted of 102 study participants. Category A consisted of study participants having CP while category B consisted of healthy normal controls with same age of same demographic features. Malocclusion, trauma, DMFS/defs, gingival index, and Oral hygiene score (OHI), and were recorded for oral examinations of al study participants However, no radiological assistance was utilized since minimal patient compliance existed in CP patients. When compared with the control category, the CP category had a higher detection of the DMFS index in the permanent teeth. The estimated defs for the CP category did not differ noticeably from the control category. In the CP category, status of hygiene of oral cavity was discovered to be substantially subpar. In comparison to the control category, the gingival condition of the CP category was noticeably worse. Treatment requirements were seen to require greater preventative care in the control category while, stainless steel crowns, pulpectomy and extractions were needed in the CP category. S. mutans was found in high concentrations in the salivary specimens of the CP category compared to the control category, indicating active dental caries and greater probability of further development.
Implant abutment using hand drivers versus torque wrench
Authors: Singh Himani
Published: March 2023

The most frequent instrument used to begin tightening screws is a manually regulated screwdriver. Regarding manually regulated screwdrivers, predicted margins of error vary between fifteen percent to forty eight percent. Mechanical Torque restricting devices can consistently produce the requisite torques. As a result, devices like wrenches are needed to achieve the desirable values of torque. Hence, the present study was designed to evaluate the torque difference between handheld drivers and torque wrench and thereby its effect on the internal threads of implant surface.120 blocks was prepared from an autopolymerizing type of acrylic material each with a dimension of 1 inch. The centre of each block was affixed with analogue of dental impalnts with dimensions of 3.5 mm width and 13 mm length. With 60 specimens each, these models were split into two categories: hand torque specimens category and torque wrench specimens category. A stereomicroscope was used to look at the implant analog's internal threading architecture at a magnification of 100. At the bottom and top, four threads were spaced apart by a certain amount. Biowizard software was used for the assessment, and the results were recorded. Threads on the internal surface of dental implants were produced once more following torquing the implant's impression, and the stereomicroscope was used to quantify the separation between the 4 threads. Statistics were used to correlate the readings. All study participants' hand torque as well as torque wrench measurements were documented and statistical analysis was performed on them. When there was statistical analysis of the measurements then it was observed that mean values of torque in specimens included category of manual torque application was found out to be 33.6 ± 6.510 Ncm. On the other hand the mean values of torque in specimens included in category of torque application by torque wrench were found out to be 33.57 ± 3.472 Ncm. The outcome showed operator heterogeneity for both categories and operator variance when using a manual driver to generate torque. One independent - sample t test was used to contrast the mean data between the two categories, and P< 0.05 was chosen to determine whether the intergroup difference was meaningful. Because the torque values obtained with hand tightening were uneven, it may be concluded that different levels of hand torquing skill caused the torque to fluctuate. The torque wrench device displayed the desired torque data in the range that the manufacturer had advised. However, utilising manual drivers and a mechanical torque instrument did not cause any modifications to thread on the internal surface, and it rarely underwent significant deformation during the preliminary tightening torque readings. Thus, given that manually hand regulated drivers create a range of torques, it may be inferred that the employment of mechanical torque restricting instruments should be required.
Faculty development: the need to ensure educational excellence and health care quality
Authors: Shin Hyekyung , Kim Min-Jeong
Published: March 2023

The definition of faculty development has been refined and expanded over the past few decades, and various definitions have been used in higher education. Initially, faculty development was defined as activities that help teachers improve teaching skills, design better curricula, and improve the organizational environment for education. Since then, as the focus of faculty development has shifted from individual professors to institutional needs, faculty development is now defined as the personal and professional development of professors, clinicians, researchers, and managers to meet institutional goals, visions, and missions in social terms and moral responsibility to the community. Faculty development in medical education is universally needed to recognize and cope with widespread changes in education, including the traditional role of professors, advances in pedagogical theory, changes in learning styles, innovative curriculum models, and evaluation philosophy. However, critics have pointed out that most universities could not actively implement faculty development or accept professors’ various demands. In this paper, various reports related to faculty development are reviewed to summarize how faculty development has progressed and present future directions for accepting various opinions to improve educational excellence and the quality of health care.
L’ethos dramaturgique de Catherine de Médicis dans La Guisiade de Pierre Matthieu
Authors: Desrosiers Diane
Published: March 2023

Dans cet article, je me propose d’analyser la construction textuelle de l’ethos discursif de Catherine de Médicis à travers les prises de parole attribuées à ce personnage dans La Guisiade (1589) de Pierre Matthieu, hostile à Henri III. Je montrerai de façon plus spécifique comment les procédés rhétoriques mis en oeuvre dans cette tragédie de la fin du XVIe siècle informent l’élaboration de l’ethos de la reine mère dans les discours épidictiques de blâme qu’elle prononce.
Ethos royal et pouvoir féminin : Laodamie, reine d’Épire (1689) de Catherine Bernard
Authors: Frappier Louise
Published: March 2023

Cet article s’intéresse à la construction de l’ethos, tout à la fois féminin et royal, du personnage éponyme dans la tragédie Laodamie, reine d’Épire de Catherine Bernard, créée en 1689 à la Comédie-Française, de même qu’à la tension générée par le conflit entre cet ethos et le pathos. Si ce pathos perturbe la « tranquillité » de la reine tout au long de l’action dramatique, celle-ci n’en parvient pas moins à le tenir en bride – mais au prix d’un immense effort – au profit de la raison, qui lui dicte de contrôler des passions qui entrent en contradiction avec les exigences de sa fonction.
Les représentations de Tullie au XVIIIe siècle : au carrefour des genres
Authors: Gladu Kim
Published: March 2023

Le personnage de Tullie, fille de Cicéron, a été représenté par plusieurs auteur·trices au XVIIIe siècle, en vertu d’un engouement qui tient sans doute autant à l’estime dont jouit le souvenir de son père qu’à un phénomène de mode selon lequel on s’intéresse aux femmes illustres de l’Antiquité. Ce sont les différentes modalités de ces représentations et de leur mise en discours qui ont retenu notre attention, dans une étude qui prend plus précisément pour objets trois oeuvres où intervient le personnage de Tullie : le roman de la marquise de Lassay, Histoire de Tullie, fille de Cicéron (1726), la tragédie Catilina (1748) de Crébillon père et enfin, le dialogue des morts de Voltaire intitulé « Les Anciens et les Modernes ou la toilette de Mme de Pompadour » (1761). Nous verrons en quoi la représentation du personnage et sa prise de parole sont tributaires de contingences liées au genre littéraire auquel appartient l’oeuvre, dans une perspective à la fois générique et dialogique.
Le système kyriarkal à l’épreuve de l’abjection chez Tahar Ben Jelloun et Assia Djebar
Authors: Scarlaken Justine , Viselli Antonio
Published: March 2023

Cet article examine ce que nous caractérisons comme l’abject carcéral (abject kyriarkal) dans Cette aveuglante absence de lumière (2001) de Tahar Ben Jelloun et « La femme en morceaux » (1997), conte tiré d’Oran, langue morte d’Assia Djebar. Ces deux ouvrages francophones, sous le paradigme théorique ultra-contemporain du système kyriarkal tel qu’il se manifeste dans la fiction théorique de Behrouz Boochani (No Friend but the Mountains, 2018) et dans les travaux de son traducteur Omid Tofighian, nous permettent de nous interroger sur la relation entre l’indicible et l’abject, sur la contamination de l’abjection à l’instance générique de ces deux ouvrages, ainsi que le rapport espace-temps chez Djebar et Ben Jelloun. Il sera particulièrement question de la manière dont l’indicible se positionne vis-à-vis de la langue coloniale ; de la textualité de l’abject—et d’une tentative de création d’un texte-prison—ainsi que du territoire ambigu que partagent la prison et l’abjection où être et non-être se confrontent, et où l’espace liminal entre la subjectivité et l’altérité domine.
Self-coalition graphs
Authors: Haynes Teresa W. , Hedetniemi Jason T. , Hedetniemi Stephen T. , McRae Alice A. , Mohan Raghuveer
Published: March 2023

A coalition in a graph \(G = (V, E)\) consists of two disjoint sets \(V_1\) and \(V_2\) of vertices, such that neither \(V_1\) nor \(V_2\) is a dominating set, but the union \(V_1 \cup V_2\) is a dominating set of \(G\). A coalition partition in a graph \(G\) of order \(n = |V|\) is a vertex partition \(\pi = \{V_1, V_2, \ldots, V_k\}\) such that every set \(V_i\) either is a dominating set consisting of a single vertex of degree \(n-1\), or is not a dominating set but forms a coalition with another set \(V_j\) which is not a dominating set. Associated with every coalition partition \(\pi\) of a graph \(G\) is a graph called the coalition graph of \(G\) with respect to \(\pi\), denoted \(CG(G,\pi)\), the vertices of which correspond one-to-one with the sets \(V_1, V_2, \ldots, V_k\) of \(\pi\) and two vertices are adjacent in \(CG(G,\pi)\) if and only if their corresponding sets in \(\pi\) form a coalition. The singleton partition \(\pi_1\) of the vertex set of \(G\) is a partition of order \(|V|\), that is, each vertex of \(G\) is in a singleton set of the partition. A graph \(G\) is called a self-coalition graph if \(G\) is isomorphic to its coalition graph \(CG(G,\pi_1)\), where \(\pi_1\) is the singleton partition of \(G\). In this paper, we characterize self-coalition graphs.
Mechanism of runaway electron generation in nanosecond pulsed plate-plate discharge at atmospheric-pressure air
Authors: Xiao Jiang-Ping , Dai Dong , Victor F. Tarasenko , Shao Tao ,   School of Electric Power, South China University of Technology, Guangzhou 510641, China,   Institute of High Current Electronics, Russian Academy of Sciences, Tomsk 634055, Russia,   Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China
Published: March 2023

Classical discharge theory (Townsend theory and streamer theory) has limitations in explaining nanosecond pulsed gas discharge. In recent years, the research on nanosecond pulsed gas discharge theory based on the high-energy runaway electrons has attracted extensive attention. But so far, there have been few studies of the generation mechanism of runaway electrons in atmospheric-pressure-air nanosecond pulsed plate-to-plate discharge, which seriously hinders the application and development of nanosecond pulse discharge plasma. In this paper, a one-dimensional implicit particle-in-cell/Monte Carlo collision (PIC/MCC) model is developed to investigate the mechanism of runaway electron generation and breakdown in a 1 mm-long atmospheric-pressure-air gap between the plate electrode and plate electrode driven by a negative nanosecond pulse voltage with an amplitude of 20 kV. The results show that under the influence of space charge dynamic behavior, the electric field enhancement region appears between the plate electrode and plate electrode, so that electrons can satisfy the electron runaway criteria and behaves in the runaway mode. In addition, it is also observed that the pre-ionization effect of the runaway electrons in front of the discharge channel can cause the secondary electron avalanches. As the secondary electrons avalanche and the discharge channel continues to converge, the discharge is guided and accelerated, eventually leading to the breakdown of the air gap. This study further reveals the mechanism of nanosecond pulsed plate-plate discharge, expands the basic theory of nanosecond pulsed gas discharge, and opens up new opportunities for the application and development of nanosecond pulsed discharge plasma.
Exudate Flavonoids of Primula veris Leaves and Their Inhibitory Activity on Lolium perrene Seed Germination
Authors: Nikolova Milena , Yankova-Tsvetkova Elina , Stefanova Tatyana , Berkov Strahil
Published: March 2023

In the present study exudate flavonoids from P. veris leaves were identified and their potential as inhibitors on L. perrene seed germination was evaluated. Leaves of P. veris were collected from natural population. Leaf exudate was obtained by dipping whole leaves into acetone for 2--3 min. Chemical composition of the exudate was analysed by GC/MS. The seed germination test was done in Petri dishes. Flavonoid aglycones were found as main components of the exudate (over 50% of all compounds). Unsubstituted flavone, 2'-methoxyflavone, 3'-methoxyflavone, 3',4'-dimethoxyflavone, 2',5'-dimethoxyflavone, 5,6,2',6'- tetramethoxyflavone were identified. Complete inhibition on Lolium perenne seed germination and root elongation by aqueous solution of the exudate at concentration 7 mg/mL was found. This is the first report about inhibitory activity of P. veris leaf exudate on seed germination.
Higher Expression Levels of miR-1246 in Advanced Laryngeal Carcinoma Are Associated with Elevated Risk of Locoregional Metastasis
Authors: Stancheva Gergana , Kyurkchiyan Silva , Petkova Veronika , Marinov Tzvetomir , Belitova Maya , Skelina Sylvia , Kaneva Radka , Popova Diana , Popov Todor
Published: March 2023

Worldwide, laryngeal squamous cell carcinoma (LSCC) is the second most common head and neck cancer (HNC). Advanced forms of LSCC, especially HPV-negative types, frequently involve locoregional lymph node metastasis, which are associated with treatment failure. Despite recent development and improvement in treatment protocols [1], still advanced LSCC is a global oncological burden, associated with challenges and complications. The study group included 60 cases of predominantly HPV-negative tumours with all patients having history of long-term smoking. We found that miR-1246 was significantly dysregulated in advanced LSCC – almost 72% of the patients in the study group showed overexpression of miR-1246 in tumour tissue above relative quantity of 2 (RQ > 2). Additionally, miR-1246 showed significant heterogeneity in expression levels between tumour depth and surface and moreover higher expression levels of the molecule correlated with higher chance of locoregional metastasis. In conclusion, we explored the expression levels of miR-1246 in advanced LSCC and adjacent normal tissue, revealing new tumour heterogeneity characteristic. We demonstrated potential association between miR-1246 expression levels and presence of locoregional lymph nodal metastasis.
Hybrid hyper-Fibonacci and hyper-Lucas numbers
Authors:   Selcuk University, Alp Yasemin
Published: March 2023

Different number systems have been studied lately. Recently, many researchers have considered the hybrid numbers which are generalization of the complex, hyperbolic and dual number systems. In this paper, we define the hybrid hyper-Fibonacci and hyper-Lucas numbers. Furthermore, we obtain some algebraic properties of these numbers such as the recurrence relations, the generating functions, the Binet’s formulas, the summation formulas, the Catalan’s identity, the Cassini’s identity and the d’Ocagne’s identity.
Disciplinary and Move Analyses of Hedging in Abstracts of DIPES II Dissertations of the Higher Teachers’ Training college of Maroua
Authors: Demanou Galbert , Arundie Tabe Camilla
Published: March 2023

This paper examines hedging as a rhetorical resource employed by fifth year (DIPES II) students of the Higher Teacher Training College of Maroua in Cameroon to show politeness, respect, humility and tentativeness in presenting their arguments or stating facts and subjective opinions. A specialized corpus of 46.368 tokens was used and hedges were retrieved using AntConc 3.4.4. Data were analyzed both quantitatively and qualitatively. The analysis shows that there is generally an unsatisfactory representation of hedges in the abstracts. The findings further reveal that markers of intentional vagueness, accuracy hedges and writer-oriented hedges are the most common hedging strategies. Students seemingly rely on relatively simpler types of hedging like some, few, may, could, a number of. Conversely, more complicated constructions such as it appears that, it is possible that seem virtually inexistent. Students in the Department of Bilingual Letters were found to be more tentative than their counterparts of other disciplines. It is equally observed that more hedging strategies are used in stating research findings than in any other communicative purpose of the abstracts. In substance, the innovation in this paper may lie on its artful combination of disciplinary investigation with move analysis of hedging in a seemingly ‘marginalized’ academic genre, and its exclusive focus on novice writing in a non-native professional academic institution. This has led to the conclusion that the use of hedging can now be regarded as not only discipline-specific but also move-specific.
Plant-exuded chemical signals induce surface attachment of the bacterial pathogen Pseudomonas syringae
Authors: O’Malley Megan R. , Kpenu Eyram , Peck Scott C. , Anderson Jeffrey C.
Published: March 2023

Many plant pathogenic bacteria suppress host defenses by secreting small molecule toxins or immune-suppressing proteins into host cells, processes that likely require close physical contact between pathogen and host. Yet, in most cases, little is known about whether phytopathogenic bacteria physically attach to host surfaces during infection. Here we report that Pseudomonas syringae pv. tomato strain DC3000, a Gram-negative bacterial pathogen of tomato and Arabidopsis, attaches to polystyrene and glass surfaces in response to chemical signals exuded from Arabidopsis seedlings and tomato leaves. We characterized the molecular nature of these attachment-inducing signals and discovered that multiple hydrophilic metabolites found in plant exudates, including citric acid, glutamic acid, and aspartic acid, are potent inducers of surface attachment. These same compounds were previously identified as inducers of P. syringae genes encoding a type III secretion system (T3SS), indicating that both attachment and T3SS deployment are induced by the same plant signals. To test if surface attachment and T3SS are regulated by the same signaling pathways, we assessed the attachment phenotypes of several previously characterized DC3000 mutants, and found that the T3SS master regulator HrpL was partially required for maximal levels of surface attachment, whereas the response regulator GacA, a negative regulator of T3SS, negatively regulated DC3000 surface attachment. Together, our data indicate that T3SS deployment and surface attachment by P. syringae may be co-regulated by the same host signals during infection, possibly to ensure close contact necessary to facilitate delivery of T3SS effectors into host cells.