bluuebunny/crossref_metadata_2025 huggingface dataset:
Report on the 13th Italian Information Retrieval Workshop (IIR 2023)
Authors: Faggioli Guglielmo , Ferrara Antonio , Nardini Franco Maria , Tonellotto Nicola
Published: January 2024

The 13th Italian Information Retrieval Workshop is the thirteenth edition of the annual conference of the Italian information retrieval and recommender systems communities. The two days of the conference gathered interesting studies and research work on a wide range of topics on information retrieval, recommender systems, and natural language processing, such as Search and Ranking, Recommendation, Content Analysis, and Classification, Artificial Intelligence, NLP, Semantics, and Dialog, Domain-Specific Applications, Human Factors and Interfaces, and Evaluation. It was hosted by the National Research Council (CNR) of Italy and the University of Pisa in a conference facility in Pisa, Italy.

Date
: 8--9 June 2023.

Website
: http://iir2023.isti.cnr.it/.
Report on the 46th ACM SIGIR Conference on Research and Development in Information Retrieval (SIGIR 2023): Reflections from the Program Co-Chairs
Authors: Kato Makoto P. , Mothe Josiane , Poblete Barbara
Published: January 2024

The ACM SIGIR Conference on Research and Development in Information Retrieval has been experiencing significant growth over the past few years. In 2023, SIGIR received a total of 822 full paper submissions and 1,787 papers/proposals. This has brought several challenges to the conference program organization. This article reports some of the main aspects of the work conducted by the program committee (PC) co-chairs for SIGIR 2023, and discusses emergent issues of the review process and program design. We expect that this document serve as a reference for future PC co-chars and as a starting point for further discussions towards improving the review process and overall conference experience.

Date
: 23--27 July 2023.

Website
: https://sigir.org/sigir2023/.
Report on The Web Search Revolution: Symposium
Authors: Sanderson Mark , Lobato Ramon , Hegarty Kieran , Given Lisa M. , Shah Chirag
Published: January 2024

This report describes a one-day symposium held at RMIT University that celebrated two milestone anniversaries in Web search: the launch in 1993 of JumpStation, the first modern web search engine; and the 25
th
anniversary since Google was incorporated as a company in 1998. The report describes the keynote presentations from Microsoft Research leader, Susan Dumais and University of Washington professor, Chirag Shah as well as three panel sessions involving leading researchers across Australia in both academia and industry. The symposium explored the impact and future directions of the web search revolution.

Date
: 17 August 2023.

Website
: https://www.admscentre.org.au/event/web-search-revolution/.
Report on the Workshop on Learning and Evaluating Recommendations with Impressions (LERI) at RecSys 2023
Authors: Dacrema Maurizio Ferrari , Castells Pablo , Basilico Justin , Cremonesi Paolo
Published: January 2024

The
Workshop on Learning and Evaluating Recommendations with Impressions
(LERI) was held in conjunction with the 17th ACM Conference on Recommender Systems (RecSys 2023). The program included a keynote, a panel discussion and 7 paper presentations. The proceedings of the workshop are available online.1 The LERI workshop focused on all aspects related to the use of impressions for recommendation with the aim to bring the community together and share experience and perspectives. Recommender systems typically rely on past user interactions as the primary source of information for making predictions. Impressions are an important source of information that indicate the items displayed on screen when the user interacted (or not) with them, and have the potential to impact the field of recommender systems in several ways. Impressions present new research questions and opportunities, but also bring new challenges.

Date
: 19 September 2023.

Website
: https://recsyspolimi.github.io/leri2023/.
Global Talent Management: A Critical Review and Research Agenda for the New Organizational Reality
Authors: Caligiuri Paula M. , Collings David G. , De Cieri Helen , Lazarova Mila B.
Published: January 2024

Global talent management (GTM) refers to management activities in a multinational enterprise (MNE) that focus on attracting, motivating, deploying, and retaining high performing and/or high potential employees in strategic roles across a firm's global operations. Despite the critical importance for individual and firm outcomes, scholarly analysis and understanding lack synthesis, and there is limited evidence that MNEs are managing their talent effectively on a global scale. In this article, we review the GTM literature and identify the challenges of implementing GTM in practice. We explore how GTM is aligned with MNE strategy, examine how talent pools are identified, and highlight the role of global mobility. We discuss GTM at the macro level, including the exogenous factors that impact talent management and the outcomes of GTM at various levels. Finally, we identify some emerging challenges and opportunities for the future of GTM.
A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo
Authors: Pettinato Mariateresa , Aghajan Mariam , Guo Shuling , Bavuso Volpe Letizia , Carleo Rossana , Nai Antonella , Pagani Alessia , Altamura Sandro , Silvestri Laura
Published: January 2024

This study uncovers a previously unrecognized mechanism of hepcidin and BMP-SMAD pathway regulation in hepatocytes mediated by the immunophilin FKBP12 and the transmembrane serine protease TMPRSS6.
Role of ZIP kinase in development of myofibroblast differentiation from HPMCs
Authors: Choo Young-Yeon , Sakai Tsuyoshi , Ikebe Reiko , Jeffers Ann , Idell Steven , Tucker Torry A. , Ikebe Mitsuo
Published: January 2024

Here, we highlight that ZIP kinase is responsible for di-phosphorylation of myosin light chain, which facilitates stress fiber formation and actomyosin-based cell contraction during mesothelial to mesenchymal transition in human pleural mesothelial cells. This transition has a significant impact on tissue remodeling and subsequent stiffness of the pleura. This study provides insight into a new therapeutic strategy for the treatment of pleural fibrosis.
Unveiling the Hidden Burden: Estimating All‐Cause Mortality Risk in Older Individuals with Type 2 Diabetes
Authors: Pan Dikang , Wang Hui , Wu Sensen , Wang Jingyu , Ning Yachan , Guo Jianming , Wang Cong , Gu Yongquan
Published: January 2024

Background. The mortality rate among older persons with diabetes has been steadily increasing, resulting in significant health and economic burdens on both society and individuals. The objective of this study is to develop and validate a predictive nomogram for estimating the 5‐year all‐cause mortality risk in older persons with T2D (T2D). Methods. We obtained data from the National Health and Nutrition Survey (NHANES). A random 7 : 3 split was made between the training and validation sets. By linking the national mortality index up until December 31, 2019, we ensured a minimum of 5 years of follow‐up to assess all‐cause mortality. A nomogram was developed in the training cohort using a logistic regression model as well as a least absolute shrinkage and selection operator (LASSO) regression model for predicting the 5‐year risk of all‐cause mortality. Finally, the prediction performance of the nomogram is evaluated using several validation methods. Results. We constructed a comprehensive prediction model based on the results of multivariate analysis and LASSO binomial regression. These models were then validated using data from the validation cohort. The final model includes four independent predictors: age, gender, estimated glomerular filtration rate, and white blood cell count. The C‐index values for the training and validation cohorts were 0.748 and 0.762, respectively. The calibration curve demonstrates satisfactory consistency between the two cohorts. Conclusions. The newly developed nomogram proves to be a valuable tool in accurately predicting the 5‐year all‐cause mortality risk among older persons with diabetes, providing crucial information for tailored interventions.
Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver Histopathology
Authors: Anbardar Mohammad Hossein , Soleimani Neda , Kazemi Kourosh , Jafarpour Zahra , Hasani Mahsa , Mohammadzadeh Sahand , Torfehnezhad Parnia , Jafarian Sedighe , Farhadi Mahsa , Sardari Mina Salari
Published: January 2024

Background. In spite of the scientific evidence supporting health advantages of mushrooms, some of them are seriously poisonous. The clinical picture of mushroom intoxication ranges from minor gastrointestinal symptoms to organ failure, such as liver failure and death. Method. We provided demographics, clinicopathological characteristics, applied treatments, and outcomes of mushroom poisoning by Lepiota species in a series of 18 cases that were referred from Kermanshah and Lorestan provinces to Abu-Ali-Sina Hospital, Shiraz, Iran. Clinical and paraclinical data were collected by taking history and reviewing of medical documents. Pathologic findings were extracted through a review of hematoxylin and eosin pathologic slides. Results. The patients were between the ages of 18 and 67 years, composed of ten females and eight males. The most frequent clinical manifestations were nausea and vomiting followed by abdominal pain. Four cases presented decreased consciousness on admission. One of them passed away. Three other cases underwent liver transplantation, two of them died after transplantation, and one fully recovered without any major issues. All instances had elevated ALT levels, which ranged from 44 to 9,140 IU/L (mean: 3259±2476), with most of them also having concurrent AST elevations (mean: 1,361±1,532). Only few patients had modest elevations in alkaline phosphatase. Total and direct bilirubin elevations up to 47.6 and 24 mg/dL, respectively, were found in most cases. Decreased total protein and albumin concentrations and increased BUN and creatinine levels were observed in some patients. In addition, some instances revealed increased LDH, increased WBC, decreased hemoglobin, and decreased platelet count. Most patients had increased prothrombin time; hematuria and positive stool occult blood were observed in few patients. Histopathologic examination of three explanted livers revealed massive necrosis with moderate to severe macrovesicular steatosis, significant ductular reaction, and parenchymal inflammation. Other patients followed a recovery process with a considerable drop in liver enzymes, especially ALT, during hospitalization utilizing conservative treatment. They had no liver problems or relevant issues after a two-year follow-up. Conclusion. In our study, highly elevated liver enzymes with a significantly high ALT/AST ratio were observed in cases of mushroom poisoning by Lepiota species, leading to fulminant liver failure and death in some cases. These laboratory findings were correlated with liver necrosis and macrovesicular steatosis in explanted livers.
Prediction Model for Safe Operation of Pumping Stations Optimized by the Sparrow Search Algorithm and BP Neural Network
Authors: Yu Ziwei , Yu Jinhuang , Liu Jinjie , Hu Chenglong , Hu Shengsheng , Wang Junjie , Zhang Hehe , Lu Huiting
Published: January 2024

The pumping station is one of the critical parts of the hydraulic structure in China. Traditional forecasting methods are limited in accuracy, time‐consuming, and high cost, resulting in limited data availability. Therefore, simulation model analysis based on soft computation is a realistic and valuable alternative. This article intends to use the BP neural network to predict the safe operation status of pump stations and optimize the initial threshold and weight information of the BP network using the sparrow search algorithm (SSA) to improve the accuracy and generalization ability of the model. In addition, to more accurately reflect the correlation between various influencing factors and the safe operation status of the pumping station, the entropy weight method and the analytic hierarchy process were used to obtain the comprehensive weights of each main influencing factor. The experimental results show that the SSA‐BP model can accurately predict the safe operation status of pumping stations, and compared with other traditional models, the SSA‐BP model has better convergence and higher accuracy. This model provides a new approach for predicting the safe operation of pumping stations and has particular reference significance for predicting the safe operation of other pumping stations.
Fabrication of Silk Fibroin Film with Strong Anticoagulant Property from the Synergy of Deep Eutectic Solvents and UV-Light Irradiation
Authors: Yu Chunyan , Pu Meiling , Chen Qiuyang , Yu Shitao , Li Lu
Published: January 2024

As a biological macromolecule, silk fibroin (SF) has great application potential in anticoagulant. However, its complex molecular structure leads to its poor solubility, which limits the application of SF. In this study, a novel SF film with strong anticoagulant properties was fabricated through the synergistic effect of LiBr deep eutectic solvents (DESs) and UV-light irradiation. Under the optimum conditions, the plasma recalcification time of SF film was 182 s, the hemolysis rate was 3.93%, and the dynamic coagulation time remained at a high level up to 60 min. The synergistic effect of UV-light and DES can promote the enhancement of hydrophilicity and the decrease of surface roughness of SF films, and thus the anticoagulant properties of the films were enhanced. The structure change, wettability, and roughness of SF films were characterized by XRD, FTIR, contact angle, and AFM. In the meantime, the wavelength of the UV-light and the irradiation time have an effect on the anticoagulant properties of the SF films. Furthermore, the improvement of the anticoagulant properties of SF films exhibits good universality for different LiBr DESs. The study provides a new direction for the preparation of strong anticoagulation SF films, as well as its application in life sciences.
Seizures, Psychosis, and Cerebral Vascular Malformation: A Rare Chain of Events
Authors: Hanine Ismail , Benallel Khadija , Benjelloun Roukaya , Kadiri Mohamed
Published: January 2024

Background. In psychiatry, anatomical abnormalities are sometimes forgotten, and this can mislead doctors into thinking that the diagnosis is purely psychiatric. A physical examination is important whenever it is possible. Even though cerebral arteriovenous malformations (cAVMs) are rare and can go unnoticed, in some cases they can cause clinical symptoms, which is a complication. Case Presentation. In this case, we describe a patient with no prior medical or psychiatric history having a cAVM diagnosed after showing psychotic symptoms (delusion and disorganized thoughts and behavior). The deep 4 × 5 cm cAVM was discovered after admitting the patient to psychiatric ward, the neurological cause has been considered after a recorded seizure, which brings the following question: Is the clinical presentation a direct result of the cAVM or is it postictal? Conclusions. An abnormality leading to another, here is how we could describe our patient’s psychopathology leading to psychotic symptoms. The two hypotheses explaining this case report have a low rate of occurring making this a rare case. Either way, neurological cause cannot be overlooked even if the clinical presentation is typical.
Preliminary Study of Subsurface Geological Setting Based on the Gravity Anomalies in Karangrejo-Tinatar Geothermal Area, Pacitan Regency, Indonesia
Authors: Puspita Mayang Bunga , Aprilla Arga Nanda , Maryanto Sukir , Sari Rendi Pradila Hab
Published: January 2024

As per the Geothermal Potential Book published by the Ministry of Energy and Mineral Resources (MEMR) in 2017, Pacitan Regency in East Java Province, Indonesia, has the potential for geothermal energy. Two hot spring manifestations, namely, Karangrejo and Tinatar, located in the Arjosari and Punung districts of Pacitan Regency, respectively, have a combined resource of 25 MWe. We acquired ground-gravity data and evaluated gravity anomalies to explore the underlying geological structure in order to understand the geothermal system behind these manifestations. The results of the study show that the gravitational anomaly in the Karangrejo-Tinatar region ranges from 163 to 176 mGal. Additional analysis of the complete Bouguer anomaly (CBA) map, first horizontal derivative (FHD) map, and field observations points to the existence of three NW-SE trending faults. Two of the faults, which are the Karangrejo fault and the Tinatar fault, may be the flow paths for the manifestation of Karangrejo and Tinatar hot springs.
Data from Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages
Authors: Stewart Delisha A. , Yang Yinmeng , Makowski Liza , Troester Melissa A.
Published: January 2024

Abstract
Basal-like breast cancer (BBC) is an aggressive subtype of breast cancer that has no biologically targeted therapy. The interactions of BBCs with stromal cells are important determinants of tumor biology, with inflammatory cells playing well-recognized roles in cancer progression. Despite the fact that macrophage–BBC communication is bidirectional, important questions remain about how BBCs affect adjacent immune cells. This study investigated monocyte-to-macrophage differentiation and polarization and gene expression in response to coculture with basal-like versus luminal breast cancer cells. Changes induced by coculture were compared with changes observed under classical differentiation and polarization conditions. Monocytes (THP-1 cells) exposed to BBC cells in coculture had altered gene expression with upregulation of both M1 and M2 macrophage markers. Two sets of M1 and M2 markers were selected from the PCR profiles and used for dual immunofluorescent staining of BBC versus luminal cocultured THP-1s, and cancer-adjacent, benign tissue sections from patients diagnosed with BBCs or luminal breast cancer, confirming the differential expression patterns. Relative to luminal breast cancers, BBCs also increased differentiation of monocytes to macrophages and stimulated macrophage migration. Consistent with these changes in cellular phenotype, a distinct pattern of cytokine secretion was evident in macrophage–BBC cocultures, including upregulation of NAP-2, osteoprotegerin, MIG, MCP-1, MCP-3, and interleukin (IL)-1β. Application of IL-1 receptor antagonist (IL-1RA) to cocultures attenuated BBC-induced macrophage migration. These data contribute to an understanding of the BBC-mediated activation of the stromal immune response, implicating specific cytokines that are differentially expressed in basal-like microenvironments and suggesting plausible targets for modulating immune responses to BBCs. Mol Cancer Res; 10(6); 727–38. ©2012 AACR.
Data from Dominant-Negative Features of Mutant TP53 in Germline Carriers Have Limited Impact on Cancer Outcomes
Authors: Monti Paola , Perfumo Chiara , Bisio Alessandra , Ciribilli Yari , Menichini Paola , Russo Debora , Umbach David M. , Resnick Michael A. , Inga Alberto , Fronza Gilberto
Published: January 2024

Abstract
Germline TP53 mutations result in cancer proneness syndromes known as Li-Fraumeni, Li-Fraumeni-like, and nonsyndromic predisposition with or without family history. To explore genotype/phenotype associations, we previously adopted a functional classification of all germline TP53 mutant alleles based on transactivation. Severe deficiency (SD) alleles were associated with more severe cancer proneness syndromes, and a larger number of tumors, compared with partial deficiency (PD) alleles. Because mutant p53 can exert dominant-negative (DN) effects, we addressed the relationship between DN and clinical manifestations. We reasoned that DN effects might be stronger in familial cancer cases associated with germline TP53 mutations, where mutant alleles coexist with the wild-type allele since conception. We examined 104 p53 mutant alleles with single amino acid substitutions described in the IARC germline database for (i) transactivation capability and (ii) capacity to reduce the activity of the wild-type allele (i.e., DN effect) using a quantitative yeast-based assay. The functional classifications of p53 alleles were then related to clinical variables. We confirmed that a classification based on transactivation alone can identify familial cancer cases with more severe clinical features. Classification based on DN effects allowed us to highlight similar associations but did not reveal distinct clinical subclasses of SD alleles, except for a correlation with tumor tissue prevalence. We conclude that in carriers of germline TP53 mutations transactivation-based classification of TP53 alleles appears more important for genotype/phenotype correlations than DN effects and that haplo-insufficiency of the TP53 gene is an important factor in cancer proneness in humans. Mol Cancer Res; 9(3); 271–9. ©2011 AACR.
Data from EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/CDKN1A Expression
Authors: Fan Tao , Jiang Shunlin , Chung Nancy , Alikhan Ali , Ni Christina , Lee Chyi-Chia Richard , Hornyak Thomas J.
Published: January 2024

Abstract
Polycomb group (PcG) proteins such as Enhancer of zeste homolog 2 (EZH2) are epigenetic transcriptional repressors that function through recognition and modification of histone methylation and chromatin structure. Targets of PcG include cell cycle regulatory proteins which govern cell cycle progression and cellular senescence. Senescence is a characteristic of melanocytic nevi, benign melanocytic proliferations that can be precursors of malignant melanoma. In this study, we report that EZH2, which we find absent in melanocytic nevi but expressed in many or most metastatic melanoma cells, functionally suppresses the senescent state in human melanoma cells. EZH2 depletion in melanoma cells inhibits cell proliferation, restores features of a cellular senescence phenotype, and inhibits growth of melanoma xenografts in vivo. p21/CDKN1A is activated upon EZH2 knockdown in a p53-independent manner and contributes substantially to cell cycle arrest and induction of a senescence phenotype. EZH2 depletion removes histone deacetylase 1 (HDAC1) from the CDKN1A transcriptional start site and downstream region, enhancing histone 3 acetylation globally and at CDKN1A. This results in recruitment of RNA polymerase II, leading to p21/CDKN1A activation. Depletion of EZH2 synergistically activates p21/CDKN1A expression in combination with the HDAC inhibitor trichostatin A. Since melanomas often retain wild-type p53 function activating p21, our findings describe a novel mechanism whereby EZH2 activation during tumor progression represses p21, leading to suppression of cellular senescence and enhanced tumorigenicity. Mol Cancer Res; 9(4); 418–29. ©2011 AACR.
Data from Low-Dose Valproic Acid Enhances Radiosensitivity of Prostate Cancer through Acetylated p53-Dependent Modulation of Mitochondrial Membrane Potential and Apoptosis
Authors: Chen Xufeng , Wong Jeffrey Y.C. , Wong Patty , Radany Eric H.
Published: January 2024

Abstract
Histone deacetylase inhibitors (HDI) have shown promise as candidate radiosensitizers for many types of cancers, including prostate cancer. However, the mechanisms of action are not well understood. In this study, we show in prostate cancer cells that valproic acid (VPA) at low concentrations has minimal cytotoxic effects yet can significantly increase radiation-induced apoptosis. VPA seems to stabilize a specific acetyl modification (lysine 120) of the p53 tumor suppressor protein, resulting in an increase in its proapoptotic function at the mitochondrial membrane. These effects of VPA are independent of any action of the p53 protein as a transcription factor in the nucleus, since these effects were also observed in native and engineered prostate cancer cells containing mutant forms of p53 protein having no transcription factor activity. Transcription levels of p53-related or Bcl-2 family member proapoptotic proteins were not affected by VPA exposure. The results of this study suggest that, in addition to nuclear-based pathways previously reported, HDIs may also result in radiosensitization at lower concentrations via a specific p53 acetylation and its mitochondrial-based pathway(s). Mol Cancer Res; 9(4); 448–61. ©2011 AACR.
Table S2 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

Supplementary Table S2 shows the antibodies used in this study.
Figure S2 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

Supplementary Figure S2 shows the effect of the inhibitors of different cell uptake pathways on marker uptake. Lung fibroblasts were pre-treated with 50 μM EIPA, 10 μM CPZ, or 200 μM Genistein for 24 h and then incubated with FITC-transferrin, Alexa488-BSA or FITC-dextran for 6 h in the continuous presence of the inhibitor (n=3 wells per group; 5 images per well). Data are presented as mean ± SD. *, p<0.05; **, p<0.01; ***, p<0.001; ns, not significant.
Figure S1 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

Supplementary Figure S1 shows characterization of EVs. (A) Western blots of whole cell lysates (WCL) and EVs from MDA-MB-231 showing EV markers and a Golgi marker (GM130, as a negative control for EV-specific proteins). (B) Nanoparticle tracking analysis (NTA) of MDA-MB-231 EVs showing size distribution (n=3 biological replicates). Data are presented as mean ± standard error of the mean (SEM).
FIGURE 6 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

MDA-MB-231 EV uptake by lung fibroblasts requires MEK2 but not MEK1. A, Fibroblasts were transfected with siRNAs against MEK1 or MEK2 (two independent siRNAs used for each gene), or with a control siRNA, at 48 hours before EVs were added for an incubation of 6 hours (n = 3 wells per group). B, Western blots of cells transfected with indicated siRNAs showing the gene knockdown efficiency of MEK1/2. C, Representative images of untreated cells and cells transfected with indicated siRNAs. Images were captured at 10 ×. Green, CFSE; yellow, DiI; blue, Hoechst 33342. Scale bar, 100 µm. D, Fibroblasts were transfected with an overexpression plasmid encoding wild-type (WT) or catalytically inactive (K101A) MEK2, or with the empty vector. Forty-eight hours later, cells were incubated with MDA-MB-231 EVs for 6 hours (n = 3 wells per group). E, Western blots of cells transfected with indicated overexpression plasmids. Data are presented as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ns, not significant.
FIGURE 3 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

Screening of a targeted library of oncology drugs by high-content microscopy identifies compounds suppressing EV uptake. A, Cells were pretreated with drugs (200 nmol/L final concentration) for 24 hours and then either assayed for viability or incubated with 10 µg/mL EV for 6 hours and assayed for EV uptake. Dynasore (80 µmol/L) was also included as a control treatment. For both MTS assay and EV uptake assay, n = 2 wells per drug were tested. For EV uptake assay, 5 images per well were captured and analyzed. Each dot represents the mean value of two replicates. Drugs resulting in >75% cell viability and <75% EV uptake efficiency were indicated in red. B, Representative images of untreated cells and cells treated with selected drugs. Images were captured at 10 ×. Green, CFSE; yellow, DiI; blue, Hoechst 33342. Scale bar, 100 µm. C, Dose-dependent analysis of the effect of Trametinib and Copanlisib. Experiments were carried out as in A using indicated concentrations of the drug. Data are represented as mean ± SD (n = 3 wells per group; 5 images per well). The best-fit IC50 of each drug is indicated. D, Validation of the effect of Trametinib and Copanlisib by flow cytometry. Experiments were carried out as in A but scaled up to a 6-well plate format. Data are represented as mean ± SD (n = 3 wells). ***, P < 0.001.
Blood Eosinophil Count and Its Determinants in a Chinese Population-Based Cohort
Authors: Yang Mei , Lv Yao , Tang Shijie , Xu Dan , Li Diandian , Liao Zenglin , Li Xiaoou , Chen Lei
Published: January 2024

Introduction: Blood eosinophil count has been shown markedly variable across different populations. However, its distribution in Chinese general population remains unclear. We aimed to investigate blood eosinophil count and its determinants in a Chinese general population. Methods: In this population-based study, general citizens of Sichuan province in China were extracted from the China Pulmonary Health study. Data on demographics, personal and family history, living condition, lifestyle, spirometry, and complete blood count test were obtained and analyzed. A stepwise multivariate binary logistic regression analysis was performed to identify determinants of high blood eosinophils (>75th percentile). Results: A total of 3,310 participants were included, with a mean age (standard deviation) of 47.0 (15.6) years. In total population, the median blood eosinophil count was 110.0 (interquartile range [IQR]: 67.2–192.9) cells/μL, lower than that in smokers (133.4 cells/μL, IQR: 79.3–228.4) and patients with asthma (140.7 cells/μL, IQR: 79.6–218.2) or post-bronchodilator airflow limitation (141.5 cells/μL, IQR: 82.6–230.1), with a right-skewed distribution. Multivariate analyses revealed that oldness (aged ≥60 years) (odds ratio [OR]: 1.66, 95% confidence interval [CI]: 1.11–2.48), smoking ≥20 pack-years (OR: 1.90, 95% CI: 1.20–3.00), raising a dog/cat (OR: 1.72, 95% CI: 1.17–2.52), and occupational exposure to dust, allergen, and harmful gas (OR: 1.58, 95% CI: 1.15–2.15) were significantly associated with high blood eosinophils. Conclusion: This study identifies a median blood eosinophil count of 110.0 cells/μL and determinants of high blood eosinophils in a Chinese general population, including oldness (aged ≥60 years), smoking ≥20 pack-years, raising a dog/cat, and occupational exposure to dust, allergen, and harmful gas.
Asymmetric Dimethylarginine Is Associated with the Phenomenon of Coronary Slow Flow in Patients with Nonvalvular Atrial Fibrillation
Authors: Du Zhaona , Jiang Wenbo , Yu Chengyun , Lu Xiuyan , Xia Wei
Published: January 2024

Introduction: Coronary slow flow phenomena (CSFP) are associated with endothelial and blood component abnormalities in coronary arteries. Asymmetric dimethylarginine (ADMA) can damage the endothelium of the heart or blood vessels in patients with non-valvular atrial fibrillation (NVAF), causing changes in levels of biological indicators. Our aim was to analyze the relationship between ADMA and CSFP in NVAF patients. Methods: We consecutively enrolled 134 patients diagnosed with NVAF and underwent coronary angiography, 50 control patients without a history of atrial fibrillation and with normal coronary angiographic flow were included at the same time. Based on the corrected TIMI frame count (CTFC), the NVAF patients were categorized into two groups, CTFC ≤27 frames and CTFC >27 frames. Plasma ADMA, P-selectin (p-sel), von Willebrand factor (vWF), D-dimer (D-Di), plasminogen activator inhibitor 1 (PAI-1), and nitric oxide (NO) were detected by ELISA in the different groups. Results: We found that plasma ADMA levels were significantly higher among NVAF patients in the CTFC >27 grade group compared with the control or CTFC ≤27 group. In addition, the levels of blood cells and endothelium-related biomarkers (NO, P-selectin, vWF, D-Di, and PAI-1) were significantly altered and correlated with ADMA levels. Multifactorial analysis showed that plasma ADMA (odd ratio [OR; 95% CI]: 1.65 [1.21–2.43], p < 0.001) and left atrial internal diameter (OR [95% CI]: 1.04 [1.02, 1.1], p < 0.001) could be used as independent risk factors for the development of CSFP in patients with NVAF. The ROC curves of ADMA can predict the development of CSFP in NVAF patients. The minimum diagnostic concentration for the development of CSFP in patients was 2.31 µmol/L. Conclusion: Our study demonstrated that CSFP in NVAF patients was associated with high levels of ADMA and left atrial internal diameter. Therefore, aggressive preoperative detection and evaluation of ADMA and left atrial internal diameter can help deal with the intraoperative presence of CSFP.
Artificial Intelligence in Surgery: The Future is Now
Authors: Guni Ahmad , Varma Piyush , Zhang Joe , Fehervari Matyas , Ashrafian Hutan
Published: January 2024

Background
Clinical Artificial intelligence (AI) has reached a critical inflection point. Advances in algorithmic science and increased understanding of operational considerations in AI deployment are opening the door to widespread clinical pathway transformation. For surgery in particular, the application of machine learning algorithms in fields such as computer vision and operative robotics are poised to radically change how we screen, diagnose, risk-stratify, treat and follow-up patients, in both pre- and post-operative stages, and within operating theatres.

Summary
In this paper, we summarise the current landscape of existing and emerging integrations within complex surgical care pathways. We investigate effective methods for practical use of AI throughout the patient pathway, from early screening and accurate diagnosis to intraoperative robotics, post-operative monitoring and follow-up. Horizon scanning of AI technologies in surgery is used to identify novel innovations that can enhance surgical practice today, with potential for paradigm shifts across core domains of surgical practice in the future.

Any AI-driven future must be built on responsible and ethical usage, reinforced by effective oversight of data governance, and of risks to patient safety in deployment. Implementation is additionally bound to considerations of usability and pathway feasibility, and the need for robust healthcare technology assessment and evidence generation. While these factors are traditionally seen as barriers to translating AI into practice, we discuss how holistic implementation practices can create a solid foundation for scaling AI across pathways.

Key Messages
The next decade will see rapid translation of experimental development into real-world impact. AI will require evolution of work practices, but will also enhance patient safety, enhance surgical quality outcomes, and provide significant value for surgeons and health systems. Surgical practice has always sat on a bedrock of technological innovation. For those that follow this tradition, the future of AI in surgery starts now.
Effectiveness of the 30-Degree Lateral Sleeping Position on Sleep Quality in Elderly Individuals Post-Stroke
Authors: Priastana I Ketut Andika , Agustini Ni Rai Sintya
Published: January 2024

Background: Post-stroke conditions can have an impact on the sleep quality of the elderly. Sleep disorders are a common health problem for the elderly, requiring serious attention. Poor sleep quality in the elderly is caused by increased sleep potential, reduced sleep efficiency, and early awakenings due to the ageing process.

Objective: This research aims to determine the effectiveness of a 30-degree lateral sleeping position compared to a supine sleeping position on the sleep quality of elderly individuals post-stroke.

Method: The design of this research uses a quasi-experiment design with a non-equivalent control group design approach. The study will be conducted in 2023 in Ekasari Village, Jembrana Regency, Bali. The total research population is 126 elderly individuals, and the sample size meeting the criteria is 64 respondents, divided into 32 respondents in the intervention group and 32 respondents in the control group. Data analysis in this study uses the Mann-Whitney U Test.

Results: The Mann-Whitney U Test shows a difference between the intervention and control groups (p = 0.000, Z score = -4.830), which means that the 30-degree lateral sleep position is better at helping older people who have had a stroke sleep better than the supine sleep position.

Conclusion: Post-stroke elderly individuals tend to experience an improvement in sleep quality when they sleep in the lateral position of 30 degrees. Therefore, elderly people who are having sleep quality issues can adopt this sleeping position to improve their sleep.
Diferença de renda entre mulheres empreendedoras e assalariadas
Authors: Rosa Samanda Silva da , Orellana Vívian dos Santos Queiroz , Menezes Gabrielito Rauter
Published: January 2024

O objetivo desse artigo é investigar o diferencial de rendimentos entre mulheres empreendedoras e assalariadas usando a Pesquisa Nacional por Amostra de Domicílios (PNAD) de 2015. Para tanto, é aplicada a decomposição detalhada de Oaxaca-Blinder e o método heckit para contornar o problema de autosseleção amostral. Os resultados encontrados sugerem que a empreendedora autônoma recebe R$11,39 por salário-hora, enquanto amulher assalariada apresenta rendimentos de R$13,51 de salário-hora. Esse cenário se altera quando analisada a situação da empregadora, que aufere R$36,70 de salário-hora. Os principais fatores que explicam essas diferenças de renda são os não observados: idade, escolaridade e viver com cônjuge.
Haroldo de Campos e Mário Laranjeira: primeiros leitores da poética do traduzir de Henri Meschonnic
Authors: Faleiros Ávaro Silveira
Published: January 2024

O objetivo deste estudo é refletir sobre aquelas que são, muito provavelmente, as duas primeiras leituras brasileiras da poética do traduzir do pensador francês de origem judaica Henri Meschonnic. Trata-se do diálogo estabelecido com ele por Haroldo de Campos e Mário Laranjeira, no qual a obra de Roman Jakobson ocupa lugar de destaque. Salientamos que esse diálogo permite compreender algumas dinâmicas importantes na invenção de uma tradição de tradução poética no Brasil.
Ainda o ritmo: Meschonnic e a tradução de Homero
Authors: Flores Guilherme Gontijo
Published: January 2024

Este breve texto busca pensar algumas condições para dar continuidade ao pensamento de Henri Meschonnic, considerando as contradições e desafios que constituem sua obra, sobretudo no que diz respeito às relações entre poesia, métrica e música. Se, como defende o poeta, teórico e tradutor francês, o ritmo não é o metro, o que o metro e a música fazem com o ritmo da linguagem? Não há resposta definitiva; e é por isso que a questão pede retornos e tensionamento. O que apresento aqui é uma reflexão sobre como Meschonnic optou por traduzir dois versos da Ilíada de Homero, para daí pensar a implicação do metro traduzido e sua relação com o ritmo.
Apontamentos preliminares para a tradução cabalística da letra Aleph
Authors: Ketzer Estevan de Negreiros
Published: January 2024

O presente trabalho aponta para alguns elementos que dizem respeito a concepção da letra Aleph na tradição hebraica. Esta letra parâmetro para pensarmos a tradução a partir da crítica do ritmo desenvolvida por Henri Meschonnic, com as contribuições de Walter Benjamin e Gershom Scholem, acerca de elementos da linguagem de difícil expressão. O som e sua repercussão como posição anterior ao arcabouço dos signos pretensamente cognoscíveis já nos dão um bom prognóstico do quanto a linguagem é mais ampla do que a língua em sua expressão vernacular. O trabalho se divide em três partes e sua conclusão versa sobre a herança dos estudos de Meschonnic para a teoria da tradução em línguas antigas.
Pensar Meschonnic e a historicidade radical da linguagem
Authors: Martins Maria Sílvia Cintra
Published: January 2024

Este artigo versa sobre a teorização do poeta, linguista e tradutor Henri Meschonnic. Levo em consideração várias obras de cunho científico do autor, sendo uma delas póstuma. Com base em resultados de pesquisa financiada pela FAPESP (2019/07879-4), proponho pensar e continuar Meschonnic na medida da compreensão e da discussão aprofundada de alguns de seus conceitos-chave, quais sejam: o signo, o sujeito do poema, historicidade, poética, modernidade e modernidade da modernidade.
Continuar a pensar Henri Meschonnic
Authors: Flores Valdir do Nascimento
Published: January 2024

Este texto apresenta uma reflexão sobre a teoria da linguagem de Henri Meschonnic tomando como categoria central a ideia do “pensar”, entendida como uma posição crítica sobre a teoria da linguagem, que dá lugar ao descontínuo da linguagem em contraposição à defesa do contínuo, o que se configura em um ponto essencial da virada epistemológica oriunda das ideias de Meschonnic. Explicitam-se, por fim, os efeitos dessa noção de “pensar” sobre os trabalhos a respeito da linguagem desenvolvidos pelo autor deste texto.
Ritmos sem número: encontros entre Henri Meschonnic e Samuel Beckett
Authors: Goldfeder André
Published: January 2024

O artigo discute afinidades e relações oblíquas entre Henri Meschonnic e Samuel Beckett, a partir de um percurso analítico por textos da coletânea Têtes-mortes (1972) representativa da ficção beckettiana tardia. Para tanto, mobiliza discussões de Meschonnic em torno das questões do ritmo, da significância, do sujeito e da “modernidade da modernidade” e aponta diálogos e contrastes entre leituras de obras de Beckett por Meschonnic, Wolfgang Iser e Theodor Adorno.
Paraísos perdidos e reconquistados na ficção científica
Authors: Morais Gabriele Cristina Borges de
Published: January 2024

O presente artigo se dispõe a analisar a influência do poema épico Paraíso perdido, de John Milton, sobre romances do gênero ficção científica. Os temas da criação artificial e da rebelião contra o criador, bem como suas consequências, serviram de fonte para diversas obras, destacando-se aqui os romances Frankenstein (Mary Shelley), A ilha do Doutor Moreau (H. G. Wells) e Flores para Algernon (Daniel Keyes). Mais do que o diálogo com o poema de Milton, exploraremos também as transformações sociais e científicas que ocorriam no período em que os textos foram escritos e que suscitaram os questionamentos éticos de seus autores.
"Floresta é o nome do mundo", de Ursula K. Le Guin: um romance de alegoria etnográfica
Authors: Rodrigues Raquel Mayne
Published: January 2024

RESUMO (RESENHA): GUIN, Ursula K. Le. Floresta é o nome do mundo. São Paulo: Morro Branco, 2020. 158 p. Tradução de Heci Regina Candiani.
Psychological Adaptation of Adults with Different Levels of Dispositional Optimism to the Risks of Digitalization in Professional Activity
Authors: Karabanova О.А. , Tikhomandrtitskaya О.А. , Molchanov S.V.
Published: January 2024

Background. The rapid pace of digitalization of economy and professional spheres as well as the necessity to identify possible psychological risks of digitalization of professional activity, predictors, conditions, and factors for successful psychological adaptation defined the relevance of the study. Objective. The goal of the study is to investigate the individual psychological adaptation to the risks of digitalization in professional activity. The tasks included studying personality adaptation to the risks associated with changes in professional activities due to digitalization as well as individual’s dispositional optimism as a predictor of adaptation to digitalization in professional activity. Methods. The author's questionnaire of psychological adaptation to digitalization in the professional field, the test of dispositional optimism (TDO-P) in the version of Gordeeva T.O., Osin E.N. and Sycheva O.A.; test of socio-psychological adaptation of Rogers — Diamond in the adaptation of A.K. Osnitsky were applied in the study. Sample. The sample consisted of 311 subjects aged 17 to 49 years. Results. The reliability and construct validity of the author's questionnaire were confirmed. Positive acceptance of digitalization of professional activity by respondents was revealed. The predominance of low adaptation signs associated with the image of professional future in its semantic and target content was found, as compared to the signs of the operational side of digitalization in the profession — mastering new technologies and forms of cooperation. Three types of adaptation to digital risks have been empirically identified and described. Conclusions. The risks of digitalization in professional activity are associated with the uncertainty of the image of the professional future, difficulties in adapting to changes and a sense of professional incompetence. Dispositional optimism, as the basis for a positive perception of the future, can be considered as a predictor for the success of an individual's adaptation to digitalization in professional sphere.
Aggressive Behaviour of Adolescents in Teachers’ Mental Representations: Risk Factors Assessment
Authors: Rean Artur A. , Konovalov Ivan A. , Kuzmin Roman G. , Linkov Anton L.
Published: January 2024

Background. The article regards the assessment of teachers' ideas about various risk factors for aggressive behaviour in adolescents. Teachers' perceptions of the factors influencing adolescents' aggressive behaviour allow us to understand how it is conceptualized, what contributes to the study of the phenomenology of adolescents' aggressive behaviour and, thus, is important for modern prevention programmes. Objective. The purpose of this article is to make a theoretical and empirical review and to identify risk factors for aggressive behaviour in adolescents assessed by teachers. Methods. The article analyzes the answers to the questions “What external and internal factors do you think to be the causes of aggressive behaviour in adolescents?” The questions were asked separately about older (15–19 years old) and younger (11–14 years old) adolescents. Spearman correlation analysis and nonparametric Wilcoxon criterion were used to assess the relationship between the indicators concerning the assessments of external and internal risk factors. Sample. The study was implemented in the form of an anonymous online survey for teachers from five federal gegions of Russian Federation. The overwhelming majority of respondents are female (94%). The average age of respondents is 44.5 (SD = 11.7). A sample of 5728 teachers was used for the analysis. Results. The analysis reveals that educators rate the significance of both external and internal factors higher in relation to the older adolescents compared to the younger ones. An inverse correlation between the teacher's age and the assessment of the significance of risk factors was revealed. Conclusion. In the course of the study we obtained results indicating the specificity in assessing the significance of risk factors for aggressive behaviour of adolescents in the teachers' perception. External and internal factors are perceived by teachers of different ages heterogeneously, which may be due to both individual characteristics of teachers and the social situation of the development of modern adolescents. This contributes to the study of the phenomenology of aggression in adolescence. The obtained results can help develop professional development programmes aimed at correct identification of risk factors on the part of teachers in order to form strategies of educational work with younger and older adolescents.