bluuebunny/crossref_metadata_2025 huggingface dataset:
Echocardiographic and electrocardiographic findings in client-owned ferrets: 95 cases (1994–2009)
Authors: Malakoff Rebecca L. , Laste Nancy J. , Orcutt Connie J.
Published: November 2012

Objective—To characterize echocardiographic and ECG findings in ferrets (Mustela putorius furo) evaluated at a clinical practice.

Design—Retrospective case series.

Animals—95 client-owned ferrets.

Procedures—Medical records of all ferrets that had a cardiac evaluation (echocardiogram with or without ECG) performed between January 1994 and November 2009 were reviewed. Data analyzed included signalment; primary clinical sign or physical examination finding that prompted cardiac evaluation; echocardiographic diagnosis; ECG diagnosis; radiographic diagnosis (if radiographs were obtained within 1 month before or after the echocardiogram); presence of congestive heart failure (CHF) defined as pulmonary edema, pleural effusion, or ascites determined to be of cardiac origin; and any available follow-up echocardiographic or ECG diagnoses.

Results—Valvular regurgitation (VR) was the most common abnormal echocardiographic finding and was diagnosed in 49 of 95 ferrets, of which 44 had aortic VR, 24 had mitral VR, and 23 had > 1 valve affected. Congestive heart failure was diagnosed in 17 of 95 ferrets, which included all 4 ferrets that had dilated cardiomyopathy. Of the 65 ferrets with ECG results, 26 had atrioventricular block, of which 7 had third-degree atrioventricular block and 6 had CHF, syncope, or weakness.

Conclusions and Clinical Relevance—The most frequent echocardiographic abnormality found in ferrets was VR, most commonly affecting the aortic and mitral valves. Dilated cardiomyopathy was infrequently diagnosed but was generally associated with CHF. The most frequent ECG abnormality was atrioventricular block, and third-degree atrioventricular block was often associated with CHF, weakness, or syncope.
Insulin glargine treatment of a ferret with diabetes mellitus
Authors: Hess Laurie
Published: November 2012

Case Description—A 7.5-year-old spayed female ferret was evaluated because of weight loss despite a good appetite. Pancreatic insulinoma had been diagnosed at another animal hospital on the basis of detection of low blood glucose concentration on 1 occasion; however, concurrent determination of blood insulin concentration was not performed. The ferret had been treated SC with methylprednisolone acetate (unknown dosage) every 30 days for 2 years. No follow-up data regarding blood glucose concentration were available.

Clinical Findings—On physical examination, the ferret was thin (weight, 0.619 kg [1.36 lb]) and bruised easily. Serum biochemical analysis revealed hyperglycemia (blood glucose concentration, 855 mg/dL; reference range, 63 to 134 mg/dL).

Treatment and Outcome—Glucocorticoid injections were discontinued, and the ferret was administered prednisolone (1.13 mg/kg [0.51 mg/lb], q 12 h for 14 days, then 0.56 mg/kg [0.25 mg/lb], q 12 h for 7 days) orally. After prednisolone administration was discontinued, hyperglycemia and weight loss persisted. The ferret was administered insulin glargine (0.5 U) SC; blood glucose concentration was monitored every 2 hours for 24 hours, at which time the value had decreased to nearly within reference range. The owner continued insulin glargine administration at that dose every 12 hours; after 77 days of treatment, the ferret's weight was 0.731 kg (1.61 lb), which was considered normal, and blood glucose concentration was within reference range.

Clinical Relevance—Regular SC administration of insulin glargine was successful in the treatment of diabetes mellitus in the ferret of this report and may be effective for other diabetic ferrets.
The efficacy of diode laser removal of leukoplakias on the tongue and in lower buccal cavity compared to other buccal cavity locations. A two-year study
Authors: Vlk Marek , Smucler Roman
Published: November 2012

Introduction. Leukoplakias of the buccal cavity are premalignant lesions with a significant 0–20% potential for malignant transformation. In addition to active follow-up screening procedures, a number of surgical interventions are recommended for their removal. One of the preferred procedures is laser ablation with consecutive histopathology using one of the many types of lasers. The efficacy of such procedure with respect to the lesion location is, however, unclear. Many studies are contradictory. Some shows laser ablations as prevention of malignisation other see it as increased risk. Aim of this is to test treatment in different locations for two years. Material and method. An outpatient ablation by a 980mm diode laser of lesions on the tongue and in the lower buccal cavity (Group A) and lesions in other parts of the buccal cavity (Group B) were performed under local anaesthesia. In total, 76 lesions were treated in 66 patients. Recurrence after 1, 3, 6, 9, 12, and 24 months were followed up. Initially, all lesions were histopathologically tested. Concurrently, the subjective tolerance of the procedure was monitored, using a 1 (ideal) to 5 (worst) scale. Results. Clearing rate of lesions was of 84.6% for Group A and of 94.7% for Group B. In two patients (3% of Group A) malignant transformation occurred which was not observed in Group B. Patient toleration in various time intervals was always higher in Group B, but generally was very high in both groups. Conclusion. Malignant transformation of leukoplakias does occur even after laser ablation, and for this reason it is necessary to subject the patients to systematic follow-ups. It is significantly higher risk of recurrences and malign transformation in tongue and oral base. Laser ablation is a simple and well-tolerated procedure with high clearing rate.
Design calculations of an extractor for aromatic and aliphatic hydrocarbons separation using ionic liquids
Authors: Graczová Elena , Steltenpohl Pavol , Šoltýs Martin , Katriňák Tomáš
Published: November 2012

The study concentrates on the separation of aromatic hydrocarbons from aliphatic hydrocarbon mixtures using ionic liquids as a new alternative of extraction solvents. Influence of the phase equilibrium description accuracy on the separation equipment design using different thermodynamic models was investigated. As a model system, a heptane-toluene binary mixture was chosen, employing 1-ethyl-3-methylimidazolium ethyl sulfate (EMIES) ionic liquid as an extractive solvent. Liquid-liquid equilibrium (LLE) data of the ternary system were calculated using NRTL equations with different quality model parameters. Model 1 corresponds to the NRTL equation with the original binary parameters evaluated independently from the respective binary equilibrium data. Model 2 is represented by an NRTL equation extended by the ternary correction term (with the original binary parameters and ternary correction term parameters evaluated from the ternary tie-lines). Model 3, i.e. the NRTL equation with binary model parameters determined via ternary LLE data regression using ASPEN Plus, was taken from Meindersma et al. (2006). Continuous-flow liquidphase extraction was simulated considering a cascade of mixer-settler type extractors according to the Hunter-Nash scheme (Hunter & Nash, 1934). Based on the simulation results, for a preset separation efficiency criterium, different accuracies of the equilibrium description caused serious discrepancies in the separation equipment design, e.g. in the number of theoretical stages, solvent to feed ratio, and product purity.
Salvaging a tooth by hemisection
Authors: Vikram M , Pai AR Vivekananda
Published: November 2012

Introduction : Hemisection may be a valuable form of treatment for molar teeth when caries has progressed to the furcation, or where there is an extensive carious lesion extending subgingivally in one area of the root, making it impossible to place an adequate restoration in that area and the root is considered unrestorable. Case Presentation : When one of the roots of a multirooted teeth is beyond the scope of restoration, it becomes imperative to remove the diseased root. This case report is about the use of hemisection procedure which was carried out to salvage the mesial portion of the mandibular right first molar.Conclusion : The use of the procedure of hemisection can successfully eliminate the need for extraction of the whole tooth if only a part of it is unrestorable. Health Renaissance; September-December 2012; Vol 10 (No.3);251-253DOI: http://dx.doi.org/10.3126/hren.v10i3.7057
Lymphangioma circumscriptum - rare site
Authors: Kar S , Mohankar A , Krishnan A
Published: November 2012

22 year old male came to Skin department with grouped vesicles over sternal region since birth along with serous discharge. The biopsy taken from site showed histopathologically Lymphangioma circumscriptum. It was treated with CO2 Laser, and response was good. Health Renaissance; September-December 2012; Vol 10 (No.3);256-257 DOI: http://dx.doi.org/10.3126/hren.v10i3.7059
Experimental and numerical investigation of the microstructural influence on the deformation behavior of notched cp-titanium specimens
Authors: Ruffing Christoph , Grad Patrick , Klassen Markus , Müller Ralf , Kerscher Eberhard
Published: November 2012

Notches lead to a decrease in the strength of machine parts in comparison to unnotched structures. The strength reduction is caused by stress concentration at the notch base. In static or dynamic calculations this effect is considered by the notch stress concentration factor. In this paper, simulations with a titanium single-crystal were carried out to analyze the dependence of the notch-stress concentration factor on the orientation of the anisotropic single-crystal material. Furthermore, numerical simulations and experiments with notched commercially pure titanium specimens have been performed to compare the stress–strain relationships until the ultimate tensile stress. The strain rate and grain size have been varied to identify dependencies on the microstructural situation which may influence the strength during the tests. After the tests, interrupted at ultimate tensile stress, metallographic sections were taken to reveal possible changes in microstructure. In the present investigation it is shown that for the single-crystal the notch-stress concentration factor depends strongly on the crystal orientation. Evidence is found that the grain size affects the strength of a notched specimen negatively, when the grain size is of the same size as the notch radius.
Referral Criteria for Assessment and Treatment: In an Ambulatory Dysphagia Clinic
Authors: Lorinczi Klara , Denheyer Vanessa , Pickard Amanda , Lee Alice , Mager Diana R.
Published: November 2012

Dysphagia is highly prevalent in patients with chronic neurological disorders and can increase the risk for comorbidities such as aspiration pneumonia and malnutrition. Treatment includes timely access to interdisciplinary health care teams with specialized skills in dysphagia management. A retrospective chart review (n=99 of 125 charts screened) was conducted to evaluate the effectiveness of referral criteria to identify and triage patients with suspected dysphagia to an ambulatory dysphagia clinic. Variables collected included demographic information (age), anthropometric information (body mass index [BMI], each patient’s sex), reason for referral, primary medical diagnosis, symptomatology (e.g., pneumonia, chest congestion), nutrition and swallowing interventions, clinic wait times, missed/cancelled appointments, and referring health care professional. The mean age and mean BMI ± standard deviation of patients reviewed were 68.7 years ± 18.4 years and 25.2 kg/m2 ± 6.7 kg/m2, respectively. Average clinic wait times were 158 days (13 to 368 days) for routine and 52 days (0 to 344 days) for urgent assessments (p<0.001). The most common reason(s) for referral was/were related to dysphagia (n=83), surgery (n=50), and/or gastrointestinal symptomatology (n=28); 80% to 90% of patients received varying diagnostic and treatment services for dysphagia. Development of effective referral criteria is critical to ensure that clients with dysphagia receive timely diagnostic, treatment, and nutrition interventions by interdisciplinary health care teams specializing in dysphagia.
Presentation, management, and outcome of newly diagnosed glioblastoma in elderly patients
Authors: Tanaka Shota , Meyer Fredric B. , Buckner Jan C. , Uhm Joon H. , Yan Elizabeth S. , Parney Ian F.
Published: November 2012

Object

Optimum management for elderly patients with newly diagnosed glioblastoma (GBM) in the temozolomide (TMZ) era is not well defined. The object of this study was to clarify outcomes in this population.

Methods

The authors retrospectively reviewed 105 consecutive cases involving elderly patients (age ≥ 65 years) with newly diagnosed GBM who were treated at the Mayo Clinic between 2003 and 2008.

Results

The patients' median age was 74 years (range 66–87 years), and the median Karnofsky Performance Status (KPS) score was 80 (range 40–90). Half of the patients underwent biopsy and half underwent resection. Patients with deep-seated lesions (19 patients [18%]) or multifocal lesions (34 patients [32%]) were more likely to have biopsy than resection (p = 0.0001 and 0.0009, respectively). New persistent neurological deficits developed in 7 patients (6.7%). Postoperative hemorrhage occurred in 6 patients (5.7%), all of whom underwent biopsy. Complete follow-up data regarding adjuvant treatment was available in 84 patients. Forty-one (49%) were treated with chemotherapy (mostly TMZ) and radiation therapy (RT), and 23 (27%) with RT alone. Nineteen (23%) received only palliative care after surgery (more common with biopsy, p = 0.03). Chemotherapy complications occurred in 28.6% (Grade 3 or 4 hematological complications in 11.9%). The median values for progression-free survival (PFS) and overall survival (OS) were 3.5 and 5.5 months. In a multivariate analysis, younger age (p = 0.03, risk ratio [RR] 0.34, 95% CI 0.13–0.89), single lesion (p = 0.02, RR 0.51, 95% CI 0.30–0.89), resection (p = 0.04, RR 0.54, 95% CI 0.31–0.94), and adjuvant treatment (p = 0.0001, RR 0.24, 95% CI 0.11–0.49) were associated with better OS. Only adjuvant treatment was significantly associated with prolonged PFS (p = 0.0007, RR 0.27, 95% CI 0.13–0.57). With combined therapy with resection, RT, and chemotherapy, the median PFS and OS were 8 and 12.5 months, respectively.

Conclusions

The prognosis for GBM worsens with increasing age in elderly patients. With important risks, resection and adjuvant treatment are associated with prolonged survival. Although selection bias cannot be excluded in this retrospective study, advanced age alone should not necessarily preclude optimal resection followed by adjuvant radiochemotherapy.
Treatment of subacute thoracic spine fracture-dislocation by total vertebrectomy and spine shortening
Authors: Barcelos Alecio C. E. S. , Botelho Ricardo V.
Published: November 2012

Vertebral resection with spine shortening has been primarily reported for the treatment of demanding cases of nontraumatic disorders. Recently, this technique has been applied to the treatment of traumatic disorders. The current treatment of vertebral fracture-dislocation when there is partial or total telescoping of the involved vertebrae is a combined anterior-posterior approach with corpectomy, anterior support implant, and further posterior instrumentation. These procedures usually require 2 surgical teams, involve longer operating times and greater risk of surgical complications related to the anterior approach, and commonly entail longer postoperative care before discharge. The authors report on 2 patients with high thoracic fracture-dislocations with telescoping (T-2 and T-4) who were treated in the subacute phase with total spondylectomy (T-3 and T-5, respectively) and spine shortening by using only a posterior approach. Complete recovery of the sagittal balance was achieved with this technique and the postoperative periods were clinically uneventful. One patient presented with asymptomatic hemothorax that did not require drainage. In paraplegic patients with anterior thoracic dislocation fractures in which one vertebral body blocks the reduction of the other, total spondylectomy and spine shortening seem to be a reasonably safe and effective technique.
Pastoral Elegy in the 1820s:The Shepherd's Calendar
Authors: Stafford Fiona
Published: November 2012

‘Adonais’ is often discussed in relation to other poems by Shelley or to other English elegies. This essay suggests that it may also illuminate other writings from the 1820s, by emphasising the traditional association of elegy with the pastoral mode. Both John Clare and James Hogg published collections entitled The Shepherd's Calendar in the 1820s and, though very different from ‘Adonais’, each can fruitfully be read as new versions of pastoral elegy. Although neither Clare's poems nor Hogg's prose stories commemorate the loss of an individual poet, both have strongly elegiac elements and explore questions often regarded as defining characteristics of the elegy, including the workings of memory and melancholy, inheritance and legacy, loss and renewal, the nature of poetry and responsibilities of the poet. The essay focuses on the poet-shepherds of the 1820s, who inherited the pastoral innovations of the later eighteenth century and contributed to the Romantic transformation of the ancient mode. Far from representing the tail-end of tradition, Hogg and Clare were following the examples of their predecessors by demonstrating the recuperative powers intrinsic to true pastoral. The Shepherds Calendars of the 1820s offer an alternative version of pastoral to Shelley's self-conscious neoclassical, post-Miltonic elegy. They adopt Gray's extension of the country elegy to an entire community and draw energy from Burns and Wordsworth, who adopted plainer language and local settings for their influential Romantic versions of pastoral. Hogg's stories drew on his local environment, but far from presenting a sentimental idyll, they exposed the presence of death in the sheep-farming communities of the Scottish Borders, even as they celebrated the distinctive way of life and thriving oral culture. Clare's poems similarly celebrate the rural world of his native Northamptonshire, but his vivid poems are intensified by a recurrent sense of loss and irreversible change. Both poet-shepherds offer a lament for a world under threat from modernity but, in doing so, they develop exciting new literary styles which are perfectly suited to the demands of a modern, predominantly urban reading public. The essay concludes with brief reference to the infusion of pastoral into the Victorian novel and the early work of one of the most significant heirs to Romantic pastoral, Thomas Hardy.
‘Hail England old England my country & home’: Englishness and the Local in John Clare's Writings
Authors: Higgins David
Published: November 2012

This article rethinks John Clare's connection to place, as well as the concepts of ‘place’ and ‘the local’ themselves. It argues that the localism of his work was enabled by potential alienation and displacement and was connected to a sense of wider national community. Clare's writings attempt to think of England in two related ways: as a political community brought together at times of threat, and as a community of taste brought together by a way of apprehending the natural world. His early patriotic verse is often strained and unconvincing, but poems such as ‘The Flitting’ present an idea of ‘native poesy’ that embodies the local and the national through careful description of the natural world. However, this idea was itself mediated through metropolitan attempts to reclaim the customs and literature of ‘merry England’. Thus Clare's localism and nationalism are shown to be ambivalent and uncanny.
Writing the Untimely: Thomas Hardy and The Well-Beloved
Authors: Fox Paul
Published: November 2012

Thomas Hardy's final novel, The Well-Beloved, is both structurally and thematically distinct from his previous ‘Wessex novels’ and has suffered critically in relationship to them. This essay argues that any consequent critical rehabilitation of this text must be predicated upon an appreciation of the late-Victorian aesthetic that the novel itself narratively portrays but equally and formally embodies. The protagonist of The Well-Beloved, Jocelyn Pierston, is examined as a failed aesthete because of his inability to realise the Ideal in his art and life. It is this disjunction between his aesthetic desire and achievement that affords the narrative moment of Hardy's novel, but the structuring of the text into three distinct ‘moments’ in Pierston's life is a successful formal rendition of the same aesthetic that the protagonist fails to achieve within the story.
A Greek Lyric Metre as Vector of the Self in the Poetry of Arthur Symons and Christopher Brennan
Authors: Buhagiar Michael
Published: November 2012

Arthur Symons was a major influence on the Australian poet Christopher Brennan (1871–1932). For his long poem The Wanderer, Brennan took from Symons's poetry of the fin de siècle the theme of longing for a lost love, and much of its associated imagery and rhythms. Chief among the latter is the dochmial rhythm of the Aeschylean drama, which expresses, in shorter irregular lines, the spasmodic emotional ejaculations of the common people, and stands in contrast to the measured iambic rhythm and longer lines of the great speeches of the nobles. Eros was highly problematic for both writers, contributing to Symons's breakdown of 1908, and Brennan's ongoing psychological crises of the 1890s. I propose that both writers’ employment of the dochmial rhythm in longer, measured lines, was to ennoble the Self as a subject worthy of respect and study, in a way typical rather of modernism than Decadence.
The Challenge of Managing Marine Biodiversity: A Practical Toolkit for a Cartographic, Territorial Approach
Authors: Bianchi Carlo , Parravicini Valeriano , Montefalcone Monica , Rovere Alessio , Morri Carla
Published: November 2012

An approach to the management of marine biodiversity was developed based on two levels of environmental diagnostics: (1) the characterization (to identify types), and (2) the evaluation (to define status and values). Both levels involve the production of maps, namely: (i) morphobathymetry and sedimentology; (ii) habitats; (iii) natural emergencies; (iv) degradation and risk; (v) weighted vulnerability; (vi) environmental quality; and, (vii) susceptibility to use. A general methodological aspect that must be stated first is the need of dividing the mapped area in territorial units corresponding to submultiples of the UTM grid and having different sizes according to the scale adopted. Territorial units (grid cells) are assigned to one of five classes of evaluation, ranging from high necessity of conservation or protection to non-problematic, unimportant or already compromised (according to the specific map) situations. Depending on the scale, these maps are suited for territorial planning (small scales, allowing for a synoptic view) or for administration and decision making (large scales, providing detail on local situations and problems). Mapping should be periodically repeated (diachronic cartography) to assure an efficient tool for integrated coastal zone management.
Fabrication of an Electrically-Resistive, Varistor-Polymer Composite
Authors: Ahmad Mansor , Fatehi Asma , Zakaria Azmi , Mahmud Shahrom , Mohammadi Sanaz
Published: November 2012

This study focuses on the fabrication and electrical characterization of a polymer composite based on nano-sized varistor powder. The polymer composite was fabricated by the melt-blending method. The developed nano-composite was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission scanning electron microscopy (FeSEM), and energy-dispersive X-ray spectroscopy (EDAX). The XRD pattern revealed the crystallinity of the composite. The XRD study also showed the presence of secondary phases due to the substitution of zinc by other cations, such as bismuth and manganese. The TEM picture of the sample revealed the distribution of the spherical, nano-sized, filler particles throughout the matrix, which were in the 10–50 nm range with an average of approximately 11 nm. The presence of a bismuth-rich phase and a ZnO matrix phase in the ZnO-based varistor powder was confirmed by FeSEM images and EDX spectra. From the current-voltage curves, the non-linear coefficient of the varistor polymer composite with 70 wt% of nano filler was 3.57, and its electrical resistivity after the onset point was 861 KΩ. The non-linear coefficient was 1.11 in the sample with 100 wt% polymer content. Thus, it was concluded that the composites established a better electrical non-linearity at higher filler amounts due to the nano-metric structure and closer particle linkages.
The Pharmacological NF-κB Inhibitor BAY11-7082 Induces Cell Apoptosis and Inhibits the Migration of Human Uveal Melanoma Cells
Authors: Hu Shuiqing , Luo Qingqiong , Cun Biyun , Hu Dan , Ge Shengfang , Fan Xianqun , Chen Fuxiang
Published: November 2012

Uveal melanomas are highly metastatic and have high rate of recurrence due to the lack of effective systemic therapy. The identification of important survival pathways in uveal melanomas provides novel therapeutic targets for effective treatment. In the present study, we found that the NF-κB signaling pathway was constitutively and highly activated in uveal melanoma cells. Treatment with the pharmacological NF-κB specific inhibitor BAY11-7082 markedly decreased the nuclear translocation of NF-κB. In a dose-dependent setting, BAY11-7082 inhibited the proliferation and growth of uveal melanoma cells by inducing apoptosis without effect on cell cycle. The migration capacity of uveal melanoma cells was also significantly suppressed by BAY11-7082 treatment. Mechanistically, BAY11-7082 increased the activity of caspase 3 and reduced the expression of anti-apoptotic protein Bcl-2, but did not influence the expression of pro-apoptotic protein Bax. Furthermore, BAY11-7082 induced uveal melanoma cell apoptosis and inhibited xenograft tumor growth in vivo. Collectively, the present study identified NF-κB as an important survival signal for uveal melanoma cells and suggested that administration of specific NF-κB inhibitor BAY11-7082 could serve as an effective treatment for patients with uveal melanoma.
A Facile Synthesis of New Monoazo Disperse Dyes Derived from 4-Hydroxyphenylazopyrazole-5-amines: Evaluation of Microwave Assisted Dyeing Behavior
Authors: Al-Etaibi Alya , El-Apasery Morsy , Ibrahim Maher , Al-Awadi Nouria
Published: November 2012

A series of new monoazo disperse dyes containing pyrazolopyrimidine moieties was synthesized by coupling malononitrile or 3-aminocrotononitrile with 4-hydroxy- benzenediazonium chloride. Treatment of the resulting products with hydrazine hydrate yields the corresponding 4-arylazoaminopyrazoles, which then react with either 2,4-pentanedione and enaminonitriles or aryl-substituted enaminoketones to give the target pyrazolopyrimidine monoazo disperse dyes. Structural assignments of the dyes were made using both NMR spectroscopic and X-ray crystallographic methods. A high temperature dyeing method, by microwave irradiation, was employed with polyester fabrics. Most of the dyed fabrics tested displayed moderate light fastness and excellent washing and perspiration fastness levels.
Increases of Quadriceps Inter-Muscular Cross-Correlation and Coherence during Exhausting Stepping Exercise
Authors: Chang Ya-Ju , Chou Ching-Chieh , Chan Hsiao-Lung , Hsu Miao-Ju , Yeh Ming-Yuh , Fang Chia-Ying , Chuang Yu-Fen , Wei Shun-Hwa , Lien Hen-Yu
Published: November 2012

The aim of this study was to examine the change of the intermuscular cross-correlation and coherence of the rectus femoris (RF), vastus medialis (VM) and vastus lateralis (VL) during exhausting stepping exercise. Eleven healthy adults repeated the stepping exercise up to their individual endurance limits (RPE score reached 20), and the cross-correlation and coherence were assessed by surface electromyography (EMG) recordings. The coefficient and time lag of cross-correlation and the coherence areas in the alpha (8–12 Hz), beta (15–30 Hz), gamma (30–60 Hz) and high-gamma (60–150 Hz) bands among the three muscle pairs (RF-VM, RF-VL and VM-VL) were calculated. As muscle fatigue, RF-VM and VM-VL showed increases of coefficients and the shortening of time lags. RF-VM and RF-VL showed increases of beta-band coherence in the ascent and descent phases, respectively. The increased intermuscular cross-correlation and beta-band coherence may be a compensatory strategy for maintaining the coordination of knee synergistic muscles during fatigue due to the fatigue-related disturbance of the corticospinal transmission. Therefore, the intermuscular cross-correlation and beta-band coherence may be a potential index for assessing muscle fatigue and monitoring the central control of motor function during dynamic fatiguing exercise.
The Impact of TV Drama Attributes on Touristic Experiences at Film Tourism Destinations
Authors: Kim Sangkyun
Published: November 2012

The nature of film tourism phenomena has a close relationship with visual, aural, and textual media representations and aesthetic values of media program production. However, little research has explored how and to what extent such production values or attributes of media program influence,
shape, and contextualize tourists' experiences at filmed locations. This current research addresses this paucity, and aims to empirically investigate the dimensions of production values and on-site film tourists' experiences and examine their relationships. Adopting a structured quantitative
survey, the exploratory factor analysis identifies two salient dimensions to represent the production values of a TV drama, namely Story and Character and Locations and Aesthetic Effects. While previous research suggested that spectacular scenery and natural backdrop was considered
as a major motivational driver in influencing audience's visit to film tourism destinations, the results of this study indicated that the dimension of Story and Character played the most significant role in explaining the level of on-site film tourists' experiences. Findings offer important
implications for destination marketers and researchers in relation to better understanding of film tourism and its touristic experiences.
« La langue », concept clinique
Authors: Toboul Bernard
Published: November 2012

Lalangue, néologisme de Lacan à la fin de son enseignement, est une avancée nouvelle de la théorie de l’inconscient, l’affranchissant du modèle linguistique. C’est aussi un concept clinique efficace pour la psychanalyse d’enfant, autour de l’acquisition du langage par l’enfant et de son accès au symbolique.
La réticence de l'enfant autiste
Authors: Rey-Flaud Henri
Published: November 2012

L’autisme n’est ni un handicap ni une maladie. Il exprime la position d’impuissance d’un enfant qui a fait le choix paradoxal de s’avancer dans la vie à l’économie du symbolique, c’est-à-dire en court-circuit du procès pulsionnel qui impose au sujet du langage d’échanger des morceaux de corps contre des signes. Cette position est celle d’une réticence, exprimée in principio à travers la rétention du regard et de la voix. Le thérapeute se doit de respecter ce retrait vital pour l’enfant (ce qui invalide d’entrée les techniques de forçage comportementalistes), en renonçant à l’attirer dans son propre monde pour l’appeler à lui-même.
L'enfant rêvé : clinique d'un changement d'adresse
Authors: Bulat-Manenti Gorana
Published: November 2012

Il arrive que l’enfant à qui l’on s’adresse ne soit pas tout à fait celui qu’on imagine... La cure avec une jeune femme démontre dans les détails de son déroulement qu’un travail analytique peut aboutir à un changement d’adresse. Un éclairage progressif d’un « angle mort », cause d’une adresse erronée, peut produire un changement d’angle d’approche et réduire l’écart entre l’enfant « rêvé » et l’enfant réel. Dans un va-et-vient entre l’universel de la théorie et le singulier de la clinique, la cure va valider ou invalider des hypothèses diverses et avancer grâce à la place faite au sujet, toujours singulier, différent de tout ce qui le précède.
Un vent d'ailleurs et d'ici
Authors: Chiang-Laluc Magnolia
Published: November 2012

Le fait d’entrer dans un univers linguistique étranger induit chez certains enfants mutisme et inhibition. À travers une vignette clinique, nous assistons à la naissance du sujet à la parole par le travail de l’analyste en tant que « truchement » entre la mère et l’enfant.
Enfance et institutions en Tunisie : quelle place pour la psychanalyse ?
Authors: Ben Smaïl Nédra
Published: November 2012

À partir du cas clinique d’un enfant de six ans diagnostiqué autiste et en passe d’être déscolarisé, Nédra Ben Smaïl analyse la violence subie par les enfants tunisiens et leurs familles, confrontés à la précarité, aux carences des politiques sociale et de santé et au déclin des formes traditionnelles des liens sociaux. La souffrance psychique des enfants impose une réflexion sur la prise en charge de la santé mentale en Tunisie. En outre, ce texte est une réflexion sur les conditions de diffusion de la pensée psychanalytique ainsi que son articulation au politique, et avance des hypothèses sur la transmission et la réceptivité de la psychanalyse dans une Tunisie post-révolutionnaire.
Usages idéologiques et fantasmatiques du signifiant « équipe »
Authors: Henri Alain-Noël
Published: November 2012

Résumé À partir d’une longue expérience de formation et de supervision auprès de praticiens de la régulation sociale, l’article aborde l’emploi du signifiant « équipe » dans sa double fonction idéologique et fantasmatique de masquage de contradictions spécifiques. Une brève enquête sur sa filiation sémantique, à partir du vocabulaire naval, montre un basculement entre la représentation d’un équipement humain, qui ne se distingue pas à l’origine d’un équipement matériel, vers celle d’un groupe coordonné de sujets de pratique. Ce qui renvoie à la contradiction entre modèles de sociabilité proto-industriels et néo-industriels. S’y ajoutent des contradictions inconscientes, plus nettement perceptibles dans les pratiques non productives : l’équipe est investie comme idéal du moi de la pratique, mais le paradoxe de l’appartenance – ce « nous » qui est à la fois pour chacun « moi » et « non-moi » – conduit à des arbitrages compliqués, qu’on éclaire de la comparaison avec le rapport entre les membres d’un couple parental et l’entité « couple ».
Le rôle du sport durant la Grande Guerre en Italie ou la mise en place d'un consensus nationaliste
Authors: Favero Jean-Pierre
Published: November 2012

Résumé La pratique sportive durant la Grande Guerre en Italie est mise au service d’un nationalisme exacerbé par les interventionnistes et la presse sportive, en particulier La Gazzetta dello Sport . Le sport au début du conflit est pratiqué par la classe dirigeante, les officiers. Les paysans et les ouvriers jetés dans la tourmente découvrent la pratique sportive, notamment le football, en zone de guerre dès 1915. Suite aux mouvements insurrectionnels liés à la défaite de Caporetto en octobre 1917, les conditions de vie des soldats sont améliorées. La Gazzetta dello Sport aidée par les autorités militaires envoie des ballons de football et des gants de boxe au front, multiplie les rencontres sportives entre régiments mais aussi entre les nations de l’Entente. L’arditisme sportif s’inspirant des valeurs des corps francs : sang-froid, intrépidité, sens du sacrifice, est mis au service du nationalisme sportif lors des rencontres internationales, notamment les Jeux Interalliés de 1919. C’est un homme nouveau qui est mis en scène à la fin du conflit préfigurant la politique fasciste où le corps symbolise la virilité et l’action.
Autour des « Maries-Louises »
Authors: Largeaud Jean-Marc
Published: November 2012

Résumé L’armée napoléonienne repose sur le principe de la conscription mais en 1813-1814 les pertes subies à partir de la campagne de Russie et l’infériorité numérique de la Grande Armée obligent à une levée massive de classes d’âge de plus en plus jeunes ; on désignera sous l’épithète « Maries-Louises » les jeunes recrues de l’année 1815, mais dans quelles limites d’âge et dans quelle proportion ? Jean-Marc Largeaud donne un compte rendu détaillé des sources historiographiques disponibles, des variations départementales et de l’engagement réel de ces jeunes soldats sur le terrain. De fait, l’appellation elle-même est tardive, même si elle est attestée une première fois sous la plume du colonel Fabvier en 1819. Ce sont les romans d’Erckmann-Chatrian, l’ Histoire d’un conscrit de 1813 (1864) et Waterloo (1865), puis ceux d’Edward Montier Les Marie-Louises (1911) et d’Henri Houssaye 1814 (1888) qui lui donnent forme dans la littérature et c’est la guerre de 1914-1918 qui donnera un statut définitif à la représentation de la jeunesse en armes, héroïque et défenseur de la patrie.
Jus ad bellum, jus in bello , l'enfance meurtrie
Authors: Poizat Denis
Published: November 2012

Résumé La souffrance ou la mort de l’enfant outrepassent tout droit de la guerre ou toute régulation morale ou politique de la violence, au cours des guerres et au-delà. La prise d’otages d’enfants dans une école, le massacre d’enfants sous des bombardements invalident l’idée même de guerre “juste”. Pour argumenter son propos, l’auteur fait appel au Dostoïevski des Frères Karamazov , à la monstruosité criminelle d’un Gilles de Rais ou au spectre de la guerre chimique. De la violence et de la cruauté inacceptable de la guerre, l’enfant devient à la fois le témoin irrévocable et l’ultime arbitre, et corrélativement le plus bel étendard de la protestation pacifiste.
Students Connecting Critical Appraisal to Evidence-Based Practice: A Teaching–Learning Activity for Research Literacy
Authors: Jakubec Sonya L. , Astle Barbara J.
Published: November 2012

This article describes the implementation of an innovative research literacy teaching–learning activity. The Research in Practice Challenge activity promoted the importance and relevance of evidence-based practice with second-year nursing students in an undergraduate research course. Students appraised the evidence within policies and practice guidelines identified by managers in practice. Collaboration among students, faculty, managers, and the librarian enabled completion of the activity. Essential skills of identifying research problems in practice, searching the literature, and critically evaluating evidence were applied. Ultimately, students were asked to respond to the question: “Does this policy or guideline need revision, and how, based upon current evidence?” Effectiveness of this activity was garnered from the students’ responses to course evaluations and analysis of teaching notes. Course evaluation revealed that students valued how the activity highlighted the relevance of research literacy for their practice. Further recommendations for research literacy teaching and learning are suggested.
Determining water quality parameters of aquifers in the Vientiane Basin, Laos, using geophysical and water chemistry data
Authors: Perttu Nils , Wattanasen Kamhaeng , Phommasone Khamphouth , Elming Sten‐Åke
Published: November 2012

The aim of this study is to test the possibility of using magnetic resonance sounding (MRS) and vertical electrical sounding (VES) together with groundwater chemistry data from shallow and deep wells to distinguish freshwater aquifers from salt affected groundwater and moreover determine water quality parameters directly from geophysical data. Three study areas within the Vientiane Basin, including 46 sites and 38 sampled wells, have been chosen for the study. The main water quality parameters affecting the water conductivity in the Vientiane Basin are total dissolved solids (TDS) and hardness and to a minor extent chloride, which all have shown to have fairly high correlation to the electrical conductivity of groundwater. The resistivity of the aquifers is highly variable but is most often above 4 Ωm, suggesting fresh water. No wells in the investigated areas have water quality parameters exceeding the limit for unacceptable drinking or irrigation water. There is a fairly strong relationship between the conductivity of water from deep wells and the conductivity of the main water bearing layer determined by VES, where the best fit is obtained using: , . However, due to equivalence in the VES interpretation and the difficulty to estimate the resistivity contribution from finer sediments, the equation may be seen and used as guidance to good water quality only within the Vientiane Basin area or in other areas with similar geology. The MRS results have been used to identify water layers in the VES inversion results to decrease the uncertainty in the interpretation The combination of MRS and VES techniques has been successful in distinguishing high conductive clay and mudstone from water bearing layers and moreover freshwater aquifers from salt affected water. Altogether, this makes MRS and VES very promising tools for guidance of future drilling and water quality estimation.
Revision of the Canadian species ofAmauromyzaHendel (Diptera: Agromyzidae)
Authors: Boucher Stéphanie
Published: November 2012

The Canadian fauna of the genusAmauromyzaHendel (Diptera: Agromyzidae) is revised and contains 11 species:Amauromyza abnormalis(Malloch),A. angulicornisZlobin,A. flavifrons(Meigen),A. karli(Hendel),A. luteiceps(Hendel),A. nevadensisSpencer,A. pleuralis(Malloch),A. ripariaSehgal,A. scleriticaSpencer,A. shepherdiaeSehgal, andA.subinfumata(Malloch). Among these, three species (A. luteiceps,A. nevadensis, andA. scleritica) are here newly recorded in Canada andA. angulicornisnewly recorded in the United States of America. Other species are significantly more widespread in Canada than previously recorded. All species are redescribed and a new identification key to Canadian species is provided.
The effect of sex and maturation on cuticular semiochemicals in Monochamus scutellatus (Coleoptera: Cerambycidae)
Authors: Brodie Bekka S. , Wickham Jacob D. , Teale Stephen A.
Published: November 2012

Contact pheromones are a subset of a complex mixture of hydrocarbons secreted on the cuticle and play an important role in the mating behaviour of several cerambycid species (Coleoptera: Cerambycidae). In this study, we investigated the relationship between maturation (newly eclosed and sexually mature) adult Monochamus scutellatus (Say) beetles and sex and the composition of the cuticular hydrocarbon blend to determine if this information is encoded in the blend and potentially available for communication purposes. Whole-body extracts of unfed females, and both mature females and males were analysed by gas chromatography mass spectrometry to identify and quantify the components of the cuticular hydrocarbons. There were no unique compounds present in any of the three groups, but discriminant analysis indicated that the relative proportions of the cuticular hydrocarbon components were unique for each group.
Molecular Characterization of the Early B Cell Response to Pulmonary Cryptococcus neoformans Infection
Authors: Rohatgi Soma , Pirofski Liise-anne
Published: November 2012

The role of B cells in host defense against fungi has been difficult to establish. We quantified and determined the molecular derivation of B-1a, B-1b, and B-2 B cell populations in C57BL/6 mice after pulmonary infection with Cryptococcus neoformans. Total B-1 and B-2 cell numbers increased in lungs and peritoneal cavity as early as day 1 postinfection, but lacked signs of clonal expansion. Labeled capsular (24067) and acapsular (Cap67) C. neoformans strains were used to identify C. neoformans–binding B cell subsets by flow cytometry. Peritoneal cavity B-1a B cells exhibited the most acapsular and capsular C. neoformans binding in C. neoformans–infected mice, and C. neoformans–selected B-1 B cells secreted laminarin- and C. neoformans–binding IgM. Single-cell PCR-based sequence analysis of B-1a, B-1b, and B-2 cell IgH V region H chain (VH) genes revealed increased usage of VH11 and VH12, respectively, in acapsular and capsular C. neoformans–selected B-1a cells. Germline VH segments were used, with capsular C. neoformans–selected cells having less junctional diversity than acapsular C. neoformans–selected cells. Further studies in B-1 B cell–depleted mice showed that these mice had higher brain and lung fungal burdens and less alveolar macrophage phagocytosis of C. neoformans than did control and B-1a B cell–reconstituted mice. Taken together, these results establish a mechanistic role for B-1 B cells in the innate B cell response to pulmonary infection with C. neoformans and reveal that IgM-producing B-1a cells, which express germline VH genes, bind C. neoformans and contribute to early fungal clearance. Thus, B-1a B cells provide a first line of defense during pulmonary C. neoformans infection in mice.
Contribution of BCR-ABL Kinase Domain Mutations to Imatinib Mesylate Resistance in Philadelphia Chromosome Positive Malaysian Chronic Myeloid Leukemia Patients
Authors: Elias Marjanu Hikmah , Baba Abdul Aziz , Husin Azlan , Abdullah Abu Dzarr , Hassan Rosline , Sim Goh Ai , Wahid S. Fadilah Abdul , Ankathil Ravindran
Published: November 2012

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as BCR-ABL dependent or BCR-ABL independent pathways. BCR-ABL dependent mechanisms are most frequently associated with point mutations in tyrosine kinase domain (TKD) of BCR-ABL1 and also with BCR-ABL gene amplification. Many different types and frequencies of mutations have been reported in different studies, probably due to the different composition of study cohorts. Since no reports are available from Malaysia, this study was undertaken to investigate the frequency and pattern of BCR-ABL kinase domain mutations using dHPLC followed by sequencing, and also status of BCR-ABL gene amplification using fluorescence in situ hybridization (FISH) on 40 IM resistant Malaysian CML patients. Mutations were detected in 13 patients (32.5%). Five different types of mutations (T315I, E255K, Y253H, M351T, V289F) were identified in these patients. In the remaining 27 IM resistant CML patients, we investigated the contribution made by BCR-ABL gene amplification, but none of these patients showed amplification. It is presumed that the mechanisms of resistance in these 27 patients might be due to BCR-ABL independent pathways. Different mutations confer different levels of resistance and, therefore, detection and characterization of TKD mutations is highly important in order to guide therapy in CML patients.
Die mooi drome van burgerlike teologie verander toe in kerklike nagmerries
Authors: Van Wyk G.M.J.
Published: November 2012

The sweet dreams of civil theology then became ecclesiastical nightmares. With the 69th General Assembly of 2010 the Netherdutch Reformed Church reached a fork in the road. The Church is still hesitating, unsure which road it should take at the fork. But she can not hesitate much longer. History will not wait infinitely for those who find it difficult to make choices on political and ecclesiastical matters. This article reflects on the recent history of the Church that brought her to this fork in the road, the different choices that are on the table for the Church at this stage and how she will shape her own future by the choices she will have to make in the near future. Rather than presenting a systematic argument on the matter at hand, the article reflects from different perspectives on the problems the Church is facing. Politics, ecclesiastical renewal, the role of tradition and heritage in ecclesiastic reflection, Church unity and the role of confessions of faith as a binding factor in the ecclesiastical community are used as points of reference to reflect on the current crisis in the Church. Church leaders are called upon to break with a tradition of civil obedience serving the interests of the politicians in power. The Church should rather bravely fulfil her calling to practise prophetic criticism in society so that she can help to promote justice for all in the most efficient way possible.