bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of natural raw rubber and silica/NR composites with low generation heat through aqueous silane flocculation
Authors: Diao Pengfei , Xiao Yao , Gong Zheng , Yang Shenglong , Wang He , Wang Chuansheng , Bian Huiguang
Published: January 2025

An aqueous aminosilane oligomer, Crosile® 8150 (hereinafter referred to as 8150) was introduced to flocculate natural rubber latex, realizing the preparation of natural raw rubber and natural rubber composites. Compared with smoked rubber, the natural raw rubber flocculated with 2, 4, and 6 phr 8150 exhibited lower glass transition temperatures, enhancing the flexibility of the molecular chain, improving the plasticity retention rates by 18.32%, 1.75%, and 22.18%, respectively, and increasing the resistance to thermo-oxidative aging. The silica/natural rubber composites prepared from natural dry rubber prepared by 8150 flocculation had superior rolling resistance properties compared to smoked rubber. The application of 8150 in the preparation of natural rubber composites eliminates the acid and salt flocculants. This reduction in the generation of waste gases and equipment corrosion during the flocculation process enhances the preparation quality of natural dry rubber. The research provides significant theoretical and practical implications for realizing high-quality natural dry rubber.
Multi-scenario territorial spatial simulation and dynamic changes: A case study of Jilin Province in China from 1985 to 2030
Authors: Shi Dan , Liu Xuan , Jin Jing , Wan Daiji , Chen Baolong , Liu Jiping
Published: January 2025

Territorial spatial resource changes play an irreplaceable role in the human development process, providing the necessary dependency conditions and ecosystem services for human production and life. This article takes Jilin Province, China, as the study area, analyzes the characteristics of the dynamic evolution of territorial spatial in Jilin Province from 1985 to 2020, and simulates the spatial and temporal changes of land space in Jilin Province under three different scenarios in 2030. The results show that: (1) From 1985 to 2020, the productive space (PS) and living space (LS) show a gradual increase trend; the ecological space (ES) shows a decrease trend. The LS is scattered except in the Changbai Mountain area; the PS is mainly concentrated in the west and expands year by year; the ES is mainly in the east, and its scope shrinks year by year. (2) From 1985 to 2020, the center of gravity of PS changes more slowly and moves northward as a whole. The change of the center of gravity of LS is mainly concentrated in Changchun, and its center of gravity is shifting southward. The center of gravity of ES moves more sharply, first to the northwest and then gradually to the southeast. (3) Under the natural development scenario in 2030, the territorial spatial area fluctuation is mainly in the north of Songyuan City, central Jilin City, and the north of Changchun City. Under the ecological protection scenario, the area dynamics of Changchun City, Songyuan City, and the northwestern part of Baicheng City change significantly. Under the economic development scenario, the hotspot areas of spatial area change are mainly in the western part of Jilin Province.
Apitherapy for diabetes mellitus: mechanisms and clinical implications
Authors: Jagua-Gualdrón Andrés , García-Reyes Nicolai Andrés , Fernández-Bernal Roger Edwin
Published: January 2025

Introduction

Diabetes mellitus is a complex disease in terms of its causes and pathophysiological processes, it produces a significant impact on health and leads to complications that are difficult to manage.

Content

This review summarizes and analyzes recent advances in the understanding of the mechanisms of diabetes mellitus and how apitherapy affects them. Also present the available clinical evidence on its application.

Apitherapy (complementary-integral use of beehive products) is a potentially useful therapeutic system with a significant level of evidence. This review shows and analyzes the preclinical and clinical evidence on the use of apitherapy in diabetes mellitus.

Outlook

Apitherapy shows significant effects on epigenetics, chronic inflammation, oxidative stress, metabolic control, dysbiosis, premature cell death and tissue remodeling. Clinical evidence shows an impact on these mechanisms. Apitherapy is a very useful complementary medicine in the treatment of diabetes mellitus.
Abrocoma bennettii (Rodentia: Abrocomidae): new records and range extension of its altitudinal distribution
Authors: Riveros-Riffo Edvin , González-Pinilla Francisco J. , Palma R. Eduardo
Published: January 2025

Bennett’s chinchilla rat (Abrocoma bennettii) is an hystricomorph rodent endemic to Chile inhabiting semi-arid and meditarranean regions below 2,000 m above sea level, from northern and central Chile. Using various lines of evidence, including camera traps, skulls, middens, and DNA, this study reports two new records of A. bennettii discovered during the course of a baseline fauna survey. These new records expand their current altitudinal limit up to 3,500 m above sea level and reveal an unprecedented potential sympatry with Abrocoma cinerea in the Andes of the Atacama Region, highlighting the ecological versatility of this common yet elusive rodent.
Optical Assay of the Functional Impact of Cuprizone-Induced Demyelination and Remyelination on Interhemispheric Neural Communication in the Anterior Cingulate Cortex via the Corpus Callosum
Authors: Tsukuda Kyoka , Tominaga Yoko , Taketoshi Makiko , Miwa Michiko , Nakashima Kentaro , Tominaga Takashi
Published: January 2025

Cuprizone (CPZ) is a widely used toxin that induces demyelinating diseases in animal models, producing multiple sclerosis (MS)-like pathology in rodents. CPZ is one of the few toxins that triggers demyelination and subsequent remyelination following the cessation of its application. This study examines the functional consequences of CPZ-induced demyelination and the subsequent recovery of neural communication within the anterior cingulate cortex (ACC), with a particular focus on interhemispheric connectivity via the corpus callosum (CC). By employing wide-field, high-speed, voltage-sensitive dye imaging, we were able to provide real-time mapping of neural activity in the ACC of CPZ-fed mice. Although we could not record physiological signals from the CC, the results demonstrated a notable impairment in interhemispheric connections within the ACC via the CC, with the most pronounced loss observed in a specific coronal slice among a series of slices examined. Notably, the latency of neural signal propagation remained largely unaltered despite connectivity loss, indicating that demyelination affects the extent, rather than the temporal dynamics, of neural communication. It is noteworthy that while functional connectivity appeared to recover fully after the cessation of CPZ, histological analysis revealed only partial recovery of myelination, indicating a discrepancy between functional and structural recovery. These findings enhance our understanding of how demyelination affects the ACC's role in orchestrating neural activity, particularly in light of the slice-specific nature of interhemispheric communication impairments. These findings offer new insights into MS pathology, particularly regarding the role of the CC in interhemispheric communication and potential therapeutic strategies.
Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep
Authors: Furman Katherine L. , Baron Lorelei , Lyons Hannah C. , Cha Timothy , Evans Jack R. , Manna Jayeeta , Zhu Limei , Mattis Joanna , Burgess Christian R.
Published: January 2025

Regulation of food intake and energy balance is critical to survival. Hunger develops as a response to energy deficit and drives food-seeking and consumption. However, motivations to eat are varied in nature, and promoted by factors other than energy deficit. When dysregulated, non-homeostatic drives to consume can contribute to disorders of food intake, adding to the increasing prevalence of restrictive eating disorders and obesity. Melanin-concentrating hormone (MCH) neurons have been implicated in the regulation of feeding behavior, in addition to a number of other fundamental behaviors including sleep, anxiety, and maternal behavior. Several studies suggest that MCH peptide increases food consumption, while studies of MCH neurons show effects only on cued feeding, and others show no effect of MCH neuron manipulation on feeding. MCH neurons have widespread projections to diverse downstream brain regions yet few studies have investigated the function of specific projections or differentiated the behaviors they regulate. Here we use optogenetics, in combination with different behavioral paradigms, to elucidate the role of MCH projections to the nucleus accumbens (NAc) in sleep and feeding behavior. We show that MCH neurons projecting to the NAc do not induce changes in baseline feeding or REM sleep, but do enhance the preference for a food paired with optogenetic stimulation. Furthermore, this effect is diminished in female mice relative to males, in line with previous results suggesting sex differences in the functional role of MCH neurons. These results suggest that MCH projections to the NAc can enhance the rewarding value of consumed food.

Significance StatementWhile feeding is often driven by hunger, there are non-homeostatic reasons why animals consume food. Melanin-concentrating hormone (MCH) neurons have been implicated in the regulation of many fundamental behaviors, including feeding, sleep and reward. They project broadly throughout the brain, suggesting that they may mediate this diverse set of behaviors independently via specific projections to downstream regions. We used optogenetic activation of MCH neurons and their projections to the nucleus accumbens (NAc) in combination with complex behavioral paradigms to demonstrate that MCH projections to the NAc do not induce baseline feeding or increases in REM sleep but do enhance the value of a paired food. These results suggest that MCH neurons contribute to non-homeostatic consumption via projections to the NAc.
Are Brenda, Juanita, and Latoya More Feminine Than Jia and Neha? Gendered Evaluations of Racialized Names
Authors: Goh Jin Xun
Published: January 2025

Names are frequently used in social science research to manipulate identities such as race and gender. However, past research has shown that racialized names (i.e., names that are associated with particular racial-ethnic groups) could signal identities that researchers did not intend, such as social class. This research tested another methodological issue concerning names in which identities intended by researchers are not signaled clearly. Three studies (N = 1,100 US participants from Prolific and CloudResearch Connect) examined the perceived femininity and masculinity of names from five racial groups: Chinese, Indian, Black, Hispanic, and White. Studies 1 and 2 consistently found that Chinese and Indian female names were perceived as less feminine and more masculine than the three other racialized female names, which contradicts extant findings using Asian female faces. Chinese and Indian male names, on the other hand, were considered more feminine and less masculine than the other racialized male names. Study 3 found that participants expressed greater uncertainty in categorizing the gender and lower confidence in knowing the gender of Chinese and Indian names compared to other racialized names. This research raises potential methodological concerns regarding the effectiveness of racialized names in signaling the gender of Asian ethnic groups.
PERJANJIAN-PERJANJIAN ANTARA BRITISH DAN KERAJAAN PAHANG 1887-1948
Authors: Hussiin Hasnah , Nordin Mardiana
Published: January 2025

Malaysian history is filled with various recordings of events. Among the biggest topics in talking about the country's history is the episode of British occupation in Malaya. Although this country has been invaded by foreign powers such as the Portuguese, the Dutch, the British and finally Japan, the British power is more dominant because it left more of an impact on Malaya from the past until now. Question that is still a question is about the status of the British occupation in this country whether they colonized or sheltered this country. However, many previous writings saw it as colonization, so the community saw Malaya as having been colonized. But there are parties who see Malaya as not colonized. This statement is still a debate among historians and intellectuals until now. The objective of this study is to record and analyze the agreements made between the British and the Government of Pahang and conclude at the end of the discussion whether the British occupation in Pahang was in the form of colonization or protectorate. This study uses a qualitative methodology based on primary sources such as reports, agreements and documents found in the national archives of Malaysia.
Pengisian sejarah Malaysia dipenuhi dengan pelbagai rakaman peristiwa. Antara topik yang paling besar dalam membicarakan tentang sejarah negara adalah episod pendudukan British di Tanah Melayu. Meskipun negara ini telah dimasuki oleh kuasa asing seperti Portugis, Belanda, British dan akhir sekali Jepun, kuasa British lebih dominan kerana ia meninggalkan lebih banyak kesan ke atas Tanah Melayu dari dahulu sehingga kini. Satu persoalan yang masih lagi menjadi tanda tanya ialah tentang status pendudukan British di negara ini sama ada mereka menjajah atau menaungi negara ini. Namun, banyak penulisan sebelum ini melihat ia sebagai penjajahan, maka masyarakat melihat Tanah Melayu telah dijajah. Tetapi ada pihak melihat Tanah Melayu tidak dijajah. Pernyataan ini masih menjadi perdebatan dalam kalangan sejarawan dah intelektual sehingga kini. Objektif kajian ini bertujuan untuk merekodkan dan menganalisis perjanjian-perjanjian yang dibuat antara British dan Kerajaan Pahang dan membuat kesimpulan di akhir perbincangan sama ada pendudukan British di Pahang adalah berbentuk penjajahan atau penaungan. Kajian ini menggunakan metodologi kualitatif berdasarkan sumber primer seperti laporan, perjanjian dan dokumen yang terdapat di arkib negara Malaysia.
EXPLORING THE MALAYSIAN CHINESE BUSINESS: A REVIEW
Authors: Ku Halim Ku Hasnan , Abdullah Mohd. Ainuddin Iskandar Lee , Haji Damin Zahrul Akmal , Yusof Yusri , Razali Jamal Rizal , Mohammad Aslam Mohd Mizan
Published: January 2025

The paper will explore  the momentum of the  Chinese business in Malaysia into a consistent and competitive performance thereby making it possible to continue to lead the domestic business environment despite the many challenges before and after independence of Malaya. This paper employed the historical views conducted through literature content analysis. As a result, the study discovered that the business strategy used, particularly the maneuver capability factors in Chinese-owned companies before and after independence. Business maneuver methods were common strategies applied by the Chinese enterprises to increase the number of firm size during the period of the implementation of NEP era. The companies responded to the government’s call in opening up the ownership of shares for the Malay-Bumiputera investors without affecting their performance. Innovation to the preservation of Chinese-owned businesses in the era of NEP indicates that the companies practiced a partnership especially the small and medium enterprises and family businesses. Overall, it has proved that the dynamics of the company's business in the Chinese business based on the concept of maneuver allowed Chinese owned companies not only to survive, but to compete successfully and expand tremendously during the NEP era.
PEMBANGUNAN DAN KEBERKESANAN MODUL KECERDASAN SPIRITUAL BAGI KESEJAHTERAAN PELAJAR B40 IPT DI MALAYSIA
Authors: Abdul Rani Anita , Abidin Imaduddin , Mat Jusoh Mohd Suhardi , Abdul Aziz Abdul Rashid , Tengku Sulaiman Tengku Intan Nabilah
Published: January 2025

Spiritual intelligence has an impact on individuals and even various studies show it as a positive influence on the well-being of workers and students. Their lives are found to be calmer and able to solve problems well. A module for B40 students was developed based on the ADDIE model to improve the spiritual intelligence of these B40 students. For the development of this module, a preliminary study was conducted on 44 B40 students to study their level of spiritual intelligence by using survey and interview methods to study the needs of the module. The module produced has undergone a content validation process from experts and its implementation to students. The development of this module is expected to provide comprehensive well-being to students as a whole and to B40 students in particular.
Kecerdasan spiritual memberi impak kepada individu malah pelbagai kajian memperlihatkan ianya sebagai pengaruh yang positif terhadap kesejahteraan pekerja maupun pelajar. Kehidupan mereka didapati akan lebih tenang dan dapat menyelesaikan masalah dengan baik. Satu modul kepada pelajar B40 dibangunkan berasaskan model ADDIE bagi meningkatkan kecerdasan spiritual pelajar B40 ini. Bagi pembangunan modul ini satu kajian awal telah dilakukan kepada 44 pelajar B40 untuk mengkaji tahap kecerdasan spiritual mereka dengan menggunakan kaedah tinjauan dan temubual untuk mengkaji keperluan modul. Modul yang dihasilkan telah menjalani proses kesahan kandungan daripada pakar dan pelaksanaannya kepada pelajar. Pembangunan modul ini diharapkan dapat memberi kesejahteraan yang menyeluruh kepada pelajar keseluruhannya dan kepada pelajar B40 khususnya.
PENGGUNAAN AIR DAN LIMAU NIPIS SEBAGAI BAHAN ASAS MERAWAT PESAKIT GANGGUAN JIN: TINJAUAN PENGALAMAN PENGAMAL DALAM PERUBATAN TRADISIONAL MELAYU
Authors: Syed Omar Syed Zaidi , Mat Said Mohamad Hilmi
Published: January 2025

This study investigates the traditional Malay medical practices involving water and lime as fundamental ingredients in treating patients believed to be afflicted by supernatural beings called Jin. The researcher is an experienced nurse specializing in Jin affliction treatment. Jin refers to creatures created by Allah from fire that can resemble angels. Nowadays, there are often reports of treatments associated with Jin disturbances in society. Unfortunately, some of these treatments don't comply with Islamic law and show signs of worrying false teachings. Therefore, the aim of this study is to identify the methods of using water and lime for Jin affliction treatment. The study's methodology is qualitative, based on the researcher's nursing experience and relevant literature review. The study's findings will explain the advantages of water and lime as treatment ingredients and the methods used in the treatment. Additionally, it will share the researcher's experiences in using these ingredients for treatment and their effectiveness with Allah's permission.
Kajian ini  merupakan satu penyelidikan berkaitan cara atau kaedah perubatan tradisi orang Melayu yang menggunakan air dan juga limau nipis sebagai bahan asas dalam rangka merawat pesakit yang diganggu oleh Jin. Pengkaji adalah merupakan seorang perawat yang berpengalaman dalam bidang rawatan gangguan Jin. Jin membawa makna makhluk Allah swt yang diciptakan daripada api yang boleh menyerupai malaikat. Dewasa ini kerap kedengaran banyak kes-kes rawatan yang dikatakan mempunyai kaitan dengan gangguan Jin dalam masyarakat. Malangnya terkadang  didapati rawatan yang digunakan tidak menepati kehendak syarak dan mempunyai tanda-tanda ajaran sesat yang membimbangkan. Justeru itu tujuan kajian ini dilakukan adalah untuk mengenalpasti kaedah penggunaan air dan limau nipis untuk rawatan gangguan Jin. Manakala metodologi kajian ini ialah kajian kualitatif. Ia berdasarkan kepada kajian lapangan iaitu pengalaman pengkaji sebagai seorang perawat dan  kajian kepustakaan yang merujuk dokumen-dokumen yang berkaitan. Hasil dari kajian ini akan menjelaskan kelebihan air dan limau nipis yang dijadikan bahan rawatan dan kaedah yang digunakan dalam rawatan di atas. Kajian ini juga akan akan berkongsikan pengalaman pengkaji yang merawat menggunakan bahan tersebut dan keberkesanannya atas izin dari Allah.
HUBUNGAN MAQASID SYARIAH, USUL FIQH & QAWAED FIQHIYYAH DALAM PENETAPAN HUKUM FEKAH SEMASA: ANALISIS BEBERAPA PANDANGAN HUKUM DAN FATWA TERPILIH DALAM ISU-ISU HALAL
Authors: Hasanuddin Ismail , Tuan Muda Tuan Sidek
Published: January 2025

Usul Fiqh, Qawaed Fiqhiyyah and Maqasid Shariah are three branches of knowledge which are usually associated with the process in determining a certain Islamic ruling. In relation to that, this paper is presented to discuss roles of these three branches and their relationship in the determination of contemporary Islamic rulings. There are similarities and differences among those three and often in term of application, misunderstandings arose. There is also a view that views opinions in the Syafie school are quite strict and need to be evaluated from the point of view of achieving maqasid shariah. Therefore, a relationship analysis was made on Islamic rulings in Malaysia in halal issues to see the extent to which the relationship of the three branches is implemented  This study was conducted qualitatively. Data were collected and analyzed using the document analysis approach. The study found that these three branches have a close relationship particularly on Islamic rulings in halal issues in Malyasia. In fact, they complement each other. Every issued Islamic ruling must be in accordance with the principles and methods that have been outlined in those three branches. From the study, it is also noted that earlier jurists have established a well-organized methodology as a guide in the process of determination of certain Islamic law.
Tiga cabang ilmu yang biasa dihubungkan dengan penetapan hukum-hukum fekah ialah ilmu Usul Fiqh, Qawaed Fiqhiyyah dan Maqasid Syariah. Tulisan ini dikemukan bagi membincangkan hubungan antara ketiga-tiga ilmu tersebut dalam penetapan hukum fekah semasa. Terdapat persamaan dan perbezaan antara ketiga-tiganya dalam penetapan hukum fekah. Terdapat juga juga salah faham dalam aplikasi ketiga-tiganya. Di samping itu, terdapat juga kata-kata yang menyebut pendapat dalam mazhab Syafie agak ketat dan perlu dinilai kembali dari sudut pencapaian maqasid syariah. Sehubungan dengan itu, analisis hubungan juga dibuat terhadap pandangan hukum semasa di Malaysia dalam isu-isu halal untuk melihat aplikasi hubungan antara ketiga-tiga cabang ilmu ini. Kajian ini dijalankan secara kualitatif. Data-data dikumpul dan dianalisis menggunakan pendekatan analisis dokumen. Kajian mendapati bahawa ketiga-tiga disiplin ilmu ini mempunyai hubungan yang rapat antara satu sama lain serta saling melengkapi dalam penetapan hukum fekah termasuk dalam penetapan pandangan hukum dalam isu-isu halal semasa. Setiap hukum fekah yang dikeluarkan perlu selaras dengan prinsip dan kaedah yang telah digariskan oleh ketiga-tiga ilmu terbabit. Kaedah yang digunakan oleh ahli-ahli fekah terdahulu telah meninggalkan suatu tradisi yang tersusun dan kukuh sebagai panduan dalam proses pengeluaran hukum.
Machining performance of SS 304 steel with hybrid nanocutting fluids using Taguchi-based gray relational analysis
Authors: Manikanta Javvadi Eswara , Ambhore Nitin , Nikhare Chetan , Gurajala Navin Kumar
Published: January 2025

Traditional cutting fluids are often insufficient in managing the heat, friction generated during machining and environmental issues. The use of hybrid nanocutting fluids contributes to green manufacturing by reducing the need for excessive coolant flow and minimizing environmental impact. This study investigates the machining performance of SS 304 steel using hybrid nanocutting fluids and evaluates the results through Taguchi-based Gray Relational Analysis (GRA). The hybrid nanocutting fluids were formulated by dispersing a combination of nanoparticles into a conventional cutting fluid. A series of turning experiments were conducted using Taguchi L27 design of experiment. The results demonstrated that the neem oil with 1.5% alumina and graphene inclusion observed significantly improved the machining efficiency of SS 304 steel, offering reduced tool temperature, cutting forces, tool vibrations and surface roughness. A notable reduction of cutting temperature, cutting force, tool vibration, and surface roughness by 35%, 18%, 27%, and 34% respectively is observed. From GRA, outstanding results is obtained at cutting speed 900 rpm, a feed rate of 40 mm/min, a depth of cut of 0.6 mm, and a 1.5 vol % concentration of hybrid nanofluid. The optimal cutting condition helps in reducing the cutting temperature, tool vibrations cutting forces and improves surface roughness.
Advancement of human-machine collaboration in manufacturing: A review on industry 1.0 - 6.0
Authors: Oladele Isiaka Oluwole , Okoro Christian , Falana Samuel , Olanrewanju Olajesu  Favour , Adelani Samson Oluwagbenga , Onuh Linus Nnubuike
Published: January 2025

The industrial revolutions have significantly influenced global production and manufacturing strategies in recent times. This was made possible due to the pivotal function of emerging technologies such as cyber-physical systems, artificial intelligence, machine learning, and the internet of things. The integration of these technologies in Industry 4.0 facilitates the establishment of smart factories, distinguished by enhanced connection, automation, and data-driven decision-making. These systems have applied cyber-physical systems in real-time interaction between physical and computer processes while artificial intelligence and machine learning enhanced production via intelligent automation and predictive maintenance. Hence, this review offers a comprehensive examination of the conceptualization of historical revolutions from Industry 1.0 to 5.0 and a futuristic outlook for Industry 6.0. The findings indicate a transformative path in human-machine interaction that showcase seamless collaboration between humans and intelligent machines. The review revealed a progression that advanced unparalleled efficiency, adaptability and customization in manufacturing processes. Thus, the review highlights the transformation from automation-centric models to a human-centric approach. The possible present and future benefits for researchers, practitioners, and policymakers in advancing technology and manufacturing as well as future outlooks were enumerated. Hence, the socio-economic impact of these trends in revolution cannot be overemphasized and, therefore, require more attention. Conclusively, available and needed materials were noticed to be part of the driving force for industrial revolution in agreement with trends in material ages.
Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor management
Authors: Karam Elias , Hollenbach Marcus , Heise Christian , Ali Einas Abou , Gulla Aiste , Auriemma Francesco , Terris Benoît , Souche François R , de Ponthaud Charles , Hank Thomas , Caillol Fabrice , Rhaiem Rami , Sauvanet Alain , Napoléon Bertrand , Regner Sara , Gaujoux Sébastien
Published: January 2025

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET), previously called ampullary gangliocytic paragangliomas, is a rare entity, with only few reported cases in the literature. This is a multicentric retrospective cohort study of patients treated with endoscopy or surgery for ampullary CoGNET. A literature review of ampullary CoGNET was also performed. Fifteen patients were included, mostly female (n = 10) with a median age of 50 years. Patients were asymptomatic in seven cases. Four patients were treated with pancreatoduodenectomy, four with transduodenal ampullectomy, and eight with endoscopic papillectomy. Clavien–Dindo III–IV complications occurred in 2 of the 8 surgical cases, but no fatal adverse events were registered. There was only one moderate endoscopic adverse event. The median length of stay was 9 days. The median tumor size was 20 mm, the R0 resection rate was 93.8%, and two patients had nodal involvement. After a median follow-up of 29 months, there was no local or distant recurrence nor death from disease. The literature review confirmed the clinical presentation and excellent outcomes of ampullary CoGNET management, especially regarding survival, even for patients with nodal or distant metastases. Overall, ampullary CoGNET are rare tumors with excellent prognosis, even with incomplete resection or nodal involvement. Treatment should be as minimally invasive as possible, and a long-term follow-up is needed.
Phenotypic and Molecular Detection of Carbapenemase-Producing Acinetobacter baumannii Strains from Clinical Specimens in Dezful Teaching Hospital
Authors: Deihim Behnaz , Khorramizadeh Maryam
Published: January 2025

Nowadays, antibiotic resistance in bacteria has become a global problem. Therefore, the identification of resistant strains of bacteria has attracted special attention in a pursue to choose more effective treatment solutions. One of the most common mechanisms of resistance is the production of carbapenemase enzyme in Acinetobacter baumannii. This present study aimed to detect carbapenemase-producing strains by phenotypic and molecular methods in clinical specimens collected in Ganjavian Hospital of Dezful between June 2021 and May 2022. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion and Etest assay, while the extended-spectrum beta-lactamase production (ESBLs) and Metalobetalactamases (MBLs) were detected by combined disk method using ceftazidime and ceftazidime/clavulanic acid disks and imipenem and imipenem /EDTA disks, respectively. Molecular detection of blaIMP, blaSPM, blaOXA-23, and blaOXA-24, blaOXA-58, blaGES genes was performed. Of a total of 54 strains, the highest resistance rate was for cephalosporins (98.1%), and ciprofloxacin (94.2%), in contrast to minocycline (13%). ESBL and MBL producers were 26% and 80%, respectively. All isolates had intermediate resistance against colistin. The most prevalent gene in the carbapenem-resistant A. baumannii (CRAB) was blaOXA-23, followed by blaOXA-24, blaGES, blaIMP, and blaOXA-58 genes. Present report highlights the existence of CRAB and intermediate resistance to colistin and also the co-existence of several genes from different carbapenemase classes in this region. Therefore, resistant strains should be identified promptly and specific treatment protocols should be devised to control the dissemination of resistance genes in therapeutic settings.
Yurii Heorhiiovych Kolosov (to the 100th Anniversary of His Birth)
Authors:   the Institute of Archaeology, the National Academy of Sciences of Ukraine, Stepanchuk V. M.
Published: January 2025

Kolosov Yurii Heorhiiovych — prehistorian, Palaeolithic archaeologist, Doctor of History, born on March 21, 1924 in Kyiv, died on March 1, 2002. Participant of the World War II, lieutenant major, artilleryman, fought on the Baltic and 2nd Ukrainian fronts, was repeatedly wounded. He was awarded the Orders of the Patriotic War, I and II class, and many medals. He graduated from the Faculty of History of Kyiv University (1949). Since 1949, he had worked in the Crimea and the Urals, at the Integrated Research Karst and Speleological Station (KNIKSS) at Moscow State University (later the Crimean Branch of the USSR Academy of Sciences). Since 1952, he had worked at the Department of History and Archaeology of the Crimean Branch of the USSR Academy of Sciences, and from 1954 to 1998 — at the Prehistory department of the Institute of Archaeology of the Ukrainian SSR Academy of Sciences (later — the Department of Stone Age Archaeology of the IA NAS of Ukraine). He is a specialist in the Palaeolithic of Ukraine, a recognised expert on the Palaeolithic of the Crimea, and a discoverer and researcher of many dozens of Palaeolithic sites. The multilayered Neanderthal sites of Zaskelna V, Zaskelna VI, Sary-Kaya, Chervona Balka, Alioshyn Grot, Prolom I and II, Kabazi II and V and others discovered and explored in the 1970s and 1980s by the Crimean Palaeolithic Expedition led by him are part of the golden fund of national and European Palaeolithic studies. He made a significant contribution to the enrichment of the source base on the prehistory of Ukraine, in particular to the study of the Middle Palaeolithic of the Crimea, worked fruitfully in the field of cultural differentiation and periodisation of the Middle Palaeolithic sites of the peninsula, technology and typology of lithic artefacts, and developed the issues of interaction between early man and the environment. He is the author of 110 scientific works, including monographs on topical issues of Palaeolithic studies. Kolosov’s research largely determined the direction of studies of the Crimean Palaeolithic in the second half of the 20th — first quarter of the 21st centuries and undoubtedly represents a separate independent chapter in the history of Eastern European Palaeolithic studies. Zaskelna VI (Kolosovskaya), one of the sites he spent many years of his life researching, is named in his honour.
Presence of Children in Household Is Associated With Increased Health-Related Social Need Burden
Authors: Vest Joshua R. , Mendonca Eneida A.
Published: January 2025

INTRODUCTION

Health-related social needs (HRSNs) are critical determinants of well-being. Children’s HRSNs are largely defined by the social status and needs of their households and caregivers. The increasing practice of HRSN screening may offer an opportunity to better assess the risks facing households with children and the risks facing pediatric patients. This study compared HRSNs between households with children and those without children.

METHODS

Adult primary care patients in Indianapolis, Indiana, completed an in-person survey between January 2022 and June 2023. The survey was comprised of instruments that measured HRSNs and identified the number of children living in their household. X2, t tests, and a series of negative binomial regressions compared the self-reported occurrence of 5 HRSNs among respondents with and without children.

RESULTS

Those with children in the household tended to be female, younger, and from racial and ethnic minority groups. The average number of HRSNs was higher for those with child in the household (1.9 vs 1.6; P = .004). Controlling for other factors, each additional child aged under 1 year increased the average number of HRSNs by 24.3% (incident rate ratio, 1.17; 95% CI, 1.03–1.33; P = .014), and with each additional child aged 1 to 4 years, the average number of HRSNs increased by 17.7% (incident rate ratio, 1.12; 95% CI, 1.01–1.25; P = .036).

CONCLUSION

These findings suggest that HRSN questionnaires completed by adults, if combined with household composition information, could be a supplementary path for health care organizations to identify the needs of pediatric patients or better understand overall needs facing their adult patients.
APPLICATION OF FUZZY PRINCIPAL COMPONENT ANALYSIS FOR THE BEST ALTERNATIVE TOURIST ATTRACTION IN YOGYAKARTA
Authors: Karjawan Aditya Rizq Herlandy , Muhajir Muhammad
Published: January 2025

One of the regions in Indonesia that depends on the tourism sector is the Special Region of Yogyakarta Province. The Province of the Special Region of Yogyakarta itself every year becomes a tourist destination province for vacations, many tourists do not know which places are the best choices for tourists. Therefore, this research aims to make it easier for tourists to obtain information on the best tourist spots in the Province of the Special Region of Yogyakarta. Based on the data obtained from the results of distributing online questionnaires during June 2022 – July 2022. The results of the study using the Fuzzy Principal Component Analysis method, it was found that the best tourist attraction is the Prambanan Temple tourist attraction with a PCA score of 0.677057 which means that Prambanan Temple becomes a tourist attraction. The most sought after by tourist visitors, followed by the Malioboro Street Area with a PCA score of 0.48146 and Parangtirtis Beach with a PCA score of 0.369162. The results of this study are expected to help tourists determine
PENERAPAN PENUGASAN MULTI-OBJECTIVE UNTUK MENGOPTIMALKAN BIAYA, WAKTU DAN KUALITAS MENGGUNAKAN METODE HUNGARIAN
Authors: Basriati Sri , Safitri Elfira , Rizki Muhammad
Published: January 2025

Various problems be facing by the company to get optimal results. One of them in this research is to optimize cost, time and quality simultaneous to get a minimal solution. The optimization of these problems uses the Hungarian method by applying multi-objective assignments. Based on the of the optimal solution results from one-objective, two-objective and three-objective assignments, these third-objective assignment is the best result. So that in the case example, the optimal solution is obtaining where the total cost incurred is Rp. 24,950,000. The total time required is 96 days. While the quality of the rattan flower vase is very good, the decorative lighting is very good and the mat is very good, the shelf is very good, the table is very good, the wardrobe is very good and the guest chair is very good.
PENGARUH PENURUNAN HARGA KELAPA SAWIT TERHADAP HARGA MINYAK GORENG PERKILOGRAM DI SUNGAI BANGEK TAHUN 2022
Authors: Sitompul Suhaimah , Faruqi Nabila Zahra , Ningsih Octavia , Gustian Yalmi , Azizah Wafiq , Cancelia Cindy , Efendy Ikhwanul Ihsan
Published: January 2025

This research was conducted in Bangek River. The purpose of this study was to determine whether there was an effect of a decrease in the price of palm oil on the price of cooking oil per kilogram in Sungai Bangek. The data that the writer uses is data obtained from interviews with cooking oil traders in Bangek River. To describe or see an overview of the object of research using descriptive statistical analysis. Cooking oil price analysis was carried out using information on the price of Fresh Fruit Bunches (FFB). To determine the relationship and influence of the independent variable (palm oil price) on the dependent variable (cooking oil price) a hypothesis test was carried out using statistical analysis with Microsoft Excel tools. Based on the results of the research and testing of the hypothesis, it can be concluded that it is true that there is an effect of a decrease in the price of palm oil on the price of cooking oil.
PENERAPAN ALGORITMA HIERARCHICAL CLUSTERING DALAM PENGELOMPOKKAN KABUPATEN/KOTA DI PAPUA BERDASARKAN INDIKATOR KEMISKINAN
Authors: Putra Fachrian Bimantoro , Dani Andrea Tri Rian , Wigantono Sri
Published: January 2025

Papua merupakan provinsi paling timur Indonesia yang memiliki kekayaan alam yang melimpah, khususnya kekayaan alam mineral. Namun hal tersebut, tidak serta merta melepaskan masyarakat Papua dari belenggu kemiskinan. Dari sudut pandang ekonomi, kemiskinan berkaitan dengan rasio ketergantungan, pendidikan, dan Kesehatan. Oleh karena itu, dalam upaya pengentasan kemiskinan di Papua, di rasa menjadi hal yang menarik dan perlu untuk melihat pengelompokkan wilayah mana saja yang perlu diprioritaskan. Pengelompokkan kabupaten/kota dilakukan dengan menggunakan algoritma hierarchical clustering, diantaranya single linkage, complete linkage, dan average linkage. Berdasarkan hasil analisis, diperoleh algoritma yang terbaik adalah complete linkage dengan jumlah klaster optimal yaitu 3 klaster. Pada klaster 1, terdapat 12 Kabupaten/Kota, klaster 2 terdapat 13 Kabupaten/Kota, dan klaster 3 terdapat 4 Kabupaten/Kota.
ANALISIS DATA LONGITUDINAL DENGAN RESPON BINER MENGGUNAKAN GENERALIZED ESTIMATING EQUATION (GEE)
Authors: Musthofa Syarto , Hasibuan Lilis Harianti , Putri Darvi Mailisa , Jannah Miftahul , Rianjaya Ilham Dangu
Published: January 2025

Data longitudinal adalah data yang diperoleh dari hasil pengukuran sejumlah individu secara berulang dalam beberapa waktu yang berbeda. Data longitudinal menunjukkan bagaimana perubahan nilai pada individu yang diamati relatif terhadap waktu dan beberapa kovariat yang menjadi perhatian. Variabel respon pada data longitudinal dimungkinkan dalam bentuk biner. Data dengan respon biner pada dasarnya bisa dianalisis dengan regresi logistik. Namun, regresi logistik tidak mempertimbangkan korelasi antar pengamatan yang mungkin terjadi pada satu individu. Dalam penelitian ini Generalized Estimating Equation (GEE) digunakan dalam melakukan estimasi parameter pada model data longitudinal. GEE memberi ruang pembahasan pada adanya kemungkinan korelasi antar pengamatan pada satu individu untuk data longitudinal yang memiliki variabel respon biner. Studi kasus dalam penelitian ini menganalisis probabilitas terjadinya kondisi suhu di atas normal berdasarkan lamanya penyinaran matahari (X_1). Estimasi parameter yang dilakukan menghasilkan model
π_i=1/(1+e^(-(-2.427+0.553x_1i)) ) dengan struktur korelasi exchangeable (α=0,607) yang menunjukkan bahwa semakin lama penyinaran matahari akan semakin memperbesar probabilitas kondisi suhu di atas normal.
Kata Kunci: Data Longitudinal, Regresi Logistik, Generalized Estimating Equation (GEE)
PENGELOMPOKAN STUNTING MENGGUNAKAN METODE K-MEDOIDS DI DAERAH ISTIMEWA YOGYAKARTA (DIY)
Authors: Cahyani Amalia Rizki , Muhajir Muhammad , Puspita Ersa Riga , Pratiwi Lathifah Aliya
Published: January 2025

Stunting, or the condition of short stature in toddlers, is a problem caused by prolonged insufficient nutrition intake. This issue arises from inadequate feeding practices that do not meet the nutritional needs of a toddler. Stunting can begin during fetal development and becomes apparent around the age of two. Several factors contribute to stunting, including high-risk levels, lack of adequate housing, lack of proper sanitation facilities, lack of access to safe drinking water, and inadequate family income. This study employs k-medoids cluster analysis to identify the grouping of sub-districts in the Yogyakarta Special Region (DIY Province) based on stunting risk factors. The research findings indicate that Cluster 1 has the highest rates of stunting and lack of family income, Cluster 4 has the highest instances of inadequate access to safe drinking water and housing, and Cluster 5 has the highest rates of inadequate sanitation facilities.
PERHITUNGAN PREMI LANJUTAN (RENEWAL PREMIUM) PADA ASURANSI KESEHATAN KUMPULAN MENGGUNAKAN METODE EXPERIENCE RATING DI PT ABC
Authors: Clarissa Putri Rumondang , Hikmah Yulial , Hikmah Ira Rosianal
Published: January 2025

Asuransi Kesehatan merupakan suatu perlindungan keuangan untuk memberikan jaminan atas biaya pengobatan dan perawatan medis yang dibutuhkan seseorang ketika sakit. Asuransi Kesehatan dibagi menjadi dua kategori, yaitu Asuransi Kesehatan Individu dan Asuransi Kesehatan Kumpulan. Asuransi Kesehatan Kumpulan ditujukan untuk para karyawan dengan Perusahaan Pemberi Kerja sebagai pemegang polisnya. Pada umumnya, Asuransi Kesehatan Kumpulan memiliki kontrak polis yang berjangka satu tahun, dimana ketika polis tersebut sudah berakhir, maka akan dilakukan evaluasi ulang untuk menentukan premi lanjutan (renewal premium). Terdapat beberapa metode yang dapat digunakan untuk menetapkan tarif premi lanjutan pada Asuransi Kesehatan Kumpulan, diantaranya manual rating, experience rating, dan blended rating. Umumnya, perusahaan asuransi menggunakan metode experience rating untuk menghitung premi lanjutan karena metode ini menggunakan data pengalaman klaim dan biaya-biaya yang terjadi di masa lalu. Pada penelitian ini dijelaskan bagaimana proses perhitungan premi lanjutan menggunakan metode experience rating dengan loss ratio. Hasil menunjukkan bahwa proses perhitungan dapat dilakukan dengan empat tahap, yaitu: menghitung loss ratio, menghitung permissible loss ratio, menghitung gross rate, dan terakhir menghitung premi lanjutan (renewal premium). Berdasarkan studi kasus di PT ABC, akan diberikan dua kemungkinan dalam penentuan besar premi lanjutan. Kemungkinan pertama yaitu besar premi lanjutan akan naik (meningkat) dari premi awal. Sementara, kemungkinan keduanya yaitu besar premi lanjutan akan tetap sama pada premi awal sebelumnya. Semakin tinggi besar klaim daripada besar premi pada suatu polis, maka akan semakin tinggi juga kemungkinan premi lanjutan (renewal premium) pada polis tersebut.
ANALISIS DINAMIK MODEL MATEMATIKA PENYEBARAN PENYAKIT KECANDUAN GAME ONLINE DENGAN MEMPERHATIKAN FAKTOR EDUKASI
Authors: Wigantono Sri , A'yun Qonita Qurrota , Sandariria Hardina , Dani Andrea Tri Rian , Fauziyah Meirinda
Published: January 2025

Kecanduan bermain game online adalah bentuk penggunaan aplikasi permainan yang kurang bijak. Dampak buruk dan banyak masalah sosial muncul akibat dari kecanduan bermain game online.  Pada penelitian ini dibahas model matematika penyebaran penyakit kecanduan bermain game online dengan memperhatikan faktor edukasi. Model ini bertipe SEAR yang terdiri atas empat kompartemen, yaitu Susceptible (rentan), Exposed (terpapar), Addicted (kecanduan), dan Recovered (sembuh). Kemudian, pada penelitian ini ditentukan titik setimbang, bilangan reproduksi dasar, dan dilakukan analisis kestabilan titik setimbang yang sudah diperoleh. Berdasarkan hasil analisis kestabilan titik setimbang, didapat bahwa titik setimbang bebas penyakit model bersifat stabil asimtotis jika bilangan reproduksi dasar bernilai kurang dari satu dan titik setimbang endemik bersifat stabil asimtotis jika bilangan reproduksi dasar bernilai lebih dari satu. Berdasarkan hasil simulasi numerik didapat bahwa ilustrasi kestabilan lokal titik setimbang sesuai dengan hasil analisis yaitu konvergen ke titik setimbangnya. Selain itu, dari hasil numerik juga menunjukkan keefektivitasan faktor edukasi pada model yaitu semakin tinggi tingkat edukasi, maka akan menurunkan populasi yang terpapar dan populasi kecanduan bermain game online.
MODEL PENGARUH SEKTOR PERIKANAN TERHADAP PERTUMBUHAN EKONOMI PERIKANAN PROVINSI-PROVINSI DI KAWASAN TIMUR INDONESIA
Authors: Situmeang Radian Januari , Titalessy Pisi Bethania
Published: January 2025

Objektifitas dari penelitian ini adalah mengetahui pengaruh jumlah nelayan, jumlah pembudidaya,angka konsumsi ikan, nilai tukar nelayan dan pembudidaya, nilai produksi perikanan tangkap dan budidaya, serta ekspor perikanan dari masing-masing provinsi di Kawasan Timur Indonesia (KTI) terhadap pertumbuhan ekonomi perikanan selama tahun 2018-2022. Data yang digunakan pada penelitian ini adalah data sekunder dari Statistik Kelautan Perikanan, Kementerian Kelautan dan Perikanan Indonesia. Provinsi yang diamati merupakan Provinsi di Kepualauan Papua, Maluku, Sulawesi dan Nusa Tenggara. Alat analisis yang digunakan adalah regresi data panel dengan pendekatan Common Effect Model (CEM), Fixed Effect Model (FEM), dan Random Effect Model (REM). Hasil penelitian mengarah bahwa bahwa model terbaik dalam penelitian ini yaitu FEM dengan R-sq. 99,25%. Faktor yang berpengaruh signifikan terhadap PDRB Perikanan yaitu Angka Konsumsi Ikan dan Nilai Tukar Nelayan. Selain memperoleh model terbaik, penelitian ini memberikan pandangan dalam interpretasi model serta saran peningkatan PDRB KTI.