bluuebunny/crossref_metadata_2025 huggingface dataset:
Downstaging and laparoscopic hepatectomy plus intraoperative radiofrequency ablation for the treatment of initially unresectable multifocal hepatocellular carcinomas
Authors: Wang Jianjun , Luo Hua , Yi Long , Yang Pei , Zeng Xintao
Published: January 2024

Background

Using TKIs plus anti-PD-1 antibodies combined with TACE in the treatment of patients with initially unresectable multiple HCCs has a high tumour response rate, and using laparoscopic hepatectomy (LH) combined with intraoperative RFA for radical treatment of multiple HCCs after successful downstaging treatment has not been reported.

Methods

Consecutive patients with multiple HCCs (≤4 lesions) who were downstaged with TKIs plus anti-PD-1 antibodies combined with TACE were analysed. Imaging examinations were performed monthly, and RECIST v1.1 criteria were used to evaluate treatment effect and resectability.

Results

Forty-five consecutive patients with multiple HCCs who met the inclusion criteria received downstaging treatment with TKIs plus anti-PD-1 antibodies combined with TACE. Nine patients were successfully downstaged and met the R0 resection criteria, and 8 patients underwent surgery. Among the patients, 5 patients had BCLC stage C, and 3 patients had BCLC stage B. There were 2 lesions in 5 patients, 3 lesions in 2 patients, and 4 lesions in 1 patient. The average size of the main HCC was 8.5 cm (range: 5.4–9.1 cm), and the diameter of the remaining HCCs was 1.6 cm (range: 0.8–2.9 cm). The average time from the start of downstaging therapy to surgery was 81 days (range: 60–210 days). All 8 patients underwent LH of the main HCC, and the remaining HCCs were targeted with RFA. The mean operation time was 220 min (range 150–370 min), the average intraoperative blood loss was 260 ml (range 100–750 ml), there was no case conversion to laparotomy, and the average postoperative hospital stay was 9 days (range 7–25 days). The incidence of postoperative complications was 37.5% and there were no deaths. The average follow-up time was 18.2 months (range 6.1–22.4 months), 5 patients survived tumour-free, 2 patients had tumour recurrence, and 1 patient died.

Conclusions

After successful downstaging of multiple HCCs by treatment with TKIs plus anti-PD-1 antibodies and TACE, LH combined with RFA for radical surgery is safe and feasible, and the treatment effect is satisfactory. It is worthy of clinical reference, and its long-term effects require further research for confirmation.
Maternal exposure to zinc oxide nanoparticles causes cochlear dysfunction in the offspring
Authors: Campagnolo Luisa , Lacconi Valentina , Bernardini Roberta , Viziano Andrea , Pietroiusti Antonio , Ippoliti Lorenzo , Moleti Arturo , Sisto Renata
Published: January 2024

Introduction: Zinc oxide nanoparticles (ZnO NPs) have been engineered and are largely used in material science and industry. This large and increasing use justifies a careful study about the toxicity of this material for human subjects. The concerns regard also the reproductive toxicity and the fetotoxicity.

Materials and methods: The effect of the exposure to ZnO NPs on the cochlear function was studied in a group of pregnant CD1 mice and in their offspring. This study is part of a larger toxicological study about the toxicity of ZnO NPs during pregnancy. Four groups were analyzed and compared, exposed and non-exposed dams and their offspring. The cochlear function was quantitatively assessed by means of Distortion Product Otoacoustic Emissions (DPOAEs).

Results and discussion: A large statistically significant difference was found between the non-exposed dams offspring and the exposed dams offspring (p = 1.6 · 10−3), whose DPOAE levels were significantly lower than those of non-exposed dams offspring and comparable to those of the adults. The DPOAE levels of the exposed and non-exposed dams were very low and not significantly different. This occurrence is related to the fact that these mice encounter a rapid aging process.

Conclusion: Our findings show that maternal exposure to ZnO NPs does not reflect in overt toxicity on fetal development nor impair offspring birth, however it may damage the nervous tissue of the inner ear in the offspring. Other studies should confirm this result and identify the mechanisms through which ZnO NPs may affect ear development.
Antimicrobial resistance of commensal Escherichia coli and Enterococcus faecalis isolated from clinically healthy captive wild animals in Seoul zoo
Authors: Kim Minsu , Kim Myeongsu , Yeo Yong-Gu , Lee Young-Tae , Han Jae-Ik
Published: January 2024

Despite the importance of antimicrobial resistance, only a few studies on the antimicrobial susceptibility on wild animals have been conducted owing to their population, accessibility, and characteristics. The objective of this study was to investigate the prevalence and characteristics of antimicrobial resistance pattern in Escherichia coli and Enterococcus faecalis isolated from the feces of captive wild animals in a zoo. A total of 61 captive wild animals were included in this study. E. coli was isolated from 58 of the 61 animals and E. faecalis was isolated from 29 animals. Among the isolated E. coli strains, ampicillin exhibited the highest resistance rate (27/29, 93.1%). Of these, 18 strains (18/29, 62%) showed multidrug resistance. The multilocus sequence typing (MLST) test showed that only ST155 was detected twice, while the other 16 strains showed different ST types. Among the E. faecalis strains, two were susceptible to all tested antimicrobials, whereas the remaining 27 strains showed resistance to one or more antimicrobials. Nine strains (9/27, 31%) showed multidrug resistance. Among the E. faecalis strains, resistance to quinupristin/dalfopristin was the highest at 96.3% (26/27), while the MLST of the nine MDR strains showed no predominant ST. Genetic association with human isolates or livestock products was observed in the isolated ST types. This indicates that antibiotic resistance in the zoo is responsible for the use of antibiotics and the partial horizontal transmission between humans and animals through feeding or contact.
No Reason to Use Mesh in Groin Hernia Repair in Adolescents
Authors: Reistrup Hugin , Fonnes Siv , Rosenberg Jacob
Published: January 2024

Groin hernias are common and hernia repair is one of the most frequent surgical procedures performed worldwide. Despite this, there is no international guideline on the management of groin hernias in adolescents. Mesh reinforcement is used for repair in adults but not in young children. Adolescents, positioned between these age groups, pose unique challenges for surgeons due to their varying growth patterns. Placing a synthetic mesh in growing patients is a concern, particularly in relation to chronic pain. Traditionally, the hernia literature has defined adults as individuals aged 18 years and above. Considering that growth can continue until age 19, this review proposes a revised definition of adolescence for patients with groin hernias encompassing ages 10 to 19. Symptomatic groin hernias in adolescents should be repaired with an open non-mesh technique because of acceptable recurrence rates and the desire to avoid introducing synthetic foreign materials into young patients with ongoing growth potential. Watchful waiting is suggested for asymptomatic groin hernias, postponing repair until the adolescent has become a fully grown adult and symptoms from the hernia develop. Most groin hernias in adolescents are lateral hernias, but before pursuing a watchful waiting strategy in females, an ultrasound or magnetic resonance imaging scan is suggested to rule out the presence of a femoral hernia that may need repair.
AG-YOLO: A Rapid Citrus Fruit Detection Algorithm with Global Context Fusion
Authors: Lin Yishen , Huang Zifan , Liang Yun , Liu Yunfan , Jiang Weipeng
Published: January 2024

Citrus fruits hold pivotal positions within the agricultural sector. Accurate yield estimation for citrus fruits is crucial in orchard management, especially when facing challenges of fruit occlusion due to dense foliage or overlapping fruits. This study addresses the issues of low detection accuracy and the significant instances of missed detections in citrus fruit detection algorithms, particularly in scenarios of occlusion. It introduces AG-YOLO, an attention-based network designed to fuse contextual information. Leveraging NextViT as its primary architecture, AG-YOLO harnesses its ability to capture holistic contextual information within nearby scenes. Additionally, it introduces a Global Context Fusion Module (GCFM), facilitating the interaction and fusion of local and global features through self-attention mechanisms, significantly improving the model’s occluded target detection capabilities. An independent dataset comprising over 8000 outdoor images was collected for the purpose of evaluating AG-YOLO’s performance. After a meticulous selection process, a subset of 957 images meeting the criteria for occlusion scenarios of citrus fruits was obtained. This dataset includes instances of occlusion, severe occlusion, overlap, and severe overlap, covering a range of complex scenarios. AG-YOLO demonstrated exceptional performance on this dataset, achieving a precision (P) of 90.6%, a mean average precision (mAP)@50 of 83.2%, and an mAP@50:95 of 60.3%. These metrics surpass existing mainstream object detection methods, confirming AG-YOLO’s efficacy. AG-YOLO effectively addresses the challenge of occlusion detection, achieving a speed of 34.22 frames per second (FPS) while maintaining a high level of detection accuracy. This speed of 34.22 FPS showcases a relatively faster performance, particularly evident in handling the complexities posed by occlusion challenges, while maintaining a commendable balance between speed and accuracy. AG-YOLO, compared to existing models, demonstrates advantages in high localization accuracy, minimal missed detection rates, and swift detection speed, particularly evident in effectively addressing the challenges posed by severe occlusions in object detection. This highlights its role as an efficient and reliable solution for handling severe occlusions in the field of object detection.
Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells
Authors: Kurihara Shunjiro , Suzuki Kotaro , Yokota Masaya , Ito Takashi , Hayashi Yuki , Kikuchi Ryo , Kageyama Takahiro , Meguro Kazuyuki , Tanaka Shigeru , Iwata Arifumi , Goto Yoshiyuki , Suto Akira , Nakajima Hiroshi
Published: January 2024

Oral tolerance has been defined as the specific suppression of immune responses to an antigen by prior oral administration of the antigen. It has been thought to serve to suppress food allergy. Previous studies have shown that dendritic cells (DCs) and regulatory T cells (Tregs) are involved in the induction of oral tolerance. However, the detailed mechanisms of Treg induction in oral tolerance remain largely unknown. Eosinophils have been recognized as effector cells in allergic diseases, but in recent years, the diverse functions of tissue-resident eosinophils have been reported. Eosinophils in the intestine have been reported to induce Tregs by releasing TGF-β, but the role of eosinophils in oral tolerance is still controversial. In this study, we analyzed the roles of eosinophils in oral tolerance using eosinophil-deficient ΔdblGATA mice (mice lacking a high-affinity GATA-binding site in the GATA1 promoter). ΔdblGATA mice showed impaired antigen-induced oral tolerance compared to wild-type mice. The induction of RORγt+ Tregs in mesenteric lymph nodes (MLNs) by oral tolerance induction was impaired in ΔdblGATA mice compared to wild-type mice. An increase in RORγt+ antigen-presenting cells (APCs), which are involved in RORγt+ Treg differentiation, in the intestine and MLNs was not seen in ΔdblGATA mice. Notably, the expansion of group 3 innate lymphoid cells (ILC3s), a subset of RORγt+ APCs, by oral tolerance induction was seen in wild-type mice but not ΔdblGATA mice. These results suggest that eosinophils are crucial in the induction of oral tolerance, possibly via the induction of RORγt+ APCs and RORγt+ Tregs.
The Impact of Different Self-Selected Walking Speeds on Muscle Synergies in Transfemoral Amputees during Transient-State Gait
Authors: Mehryar Pouyan , Shourijeh Mohammad , Rezaeian Tahmineh , Khandan Aminreza , Messenger Neil , O’Connor Rory , Farahmand Farzam , Dehghani-Sanij Abbas
Published: January 2024

Facing above-knee amputation poses a significant hurdle due to its profound impact on walking ability. To overcome this challenge, a complex adaptation strategy is necessary at the neuromuscular level to facilitate safe movement with a prosthesis. Prior research conducted on lower-limb amputees has shown a comparable amount of intricacy exhibited by the neurological system, regardless of the level of amputation and state of walking. This research investigated the differences in muscle synergies among individuals with unilateral transfemoral amputations during walking at three different speeds of transient-state gait. Surface electromyography was recorded from eleven male transfemoral amputees’ intact limbs (TFA), and the concatenated non-negative matrix factorization technique was used to identify muscle synergy components, synergy vectors (S), and activation coefficient profiles (C). Results showed varying levels of correlation across paired-speed comparisons in TFA, categorized as poor (S1), moderate (S3 and S4), and strong (S2). Statistically significant differences were observed in all activation coefficients except C3, particularly during the stance phase. This study can assist therapists in understanding muscle coordination in TFA during unsteady gait, contributing to rehabilitation programs for balance and mobility improvement, and designing myoelectric prosthetic systems to enhance their responsiveness to trips or falls.
An Explainable AI System for the Diagnosis of High-Dimensional Biomedical Data
Authors: Ultsch Alfred , Hoffmann Jörg , Röhnert Maximilian A. , von Bonin Malte , Oelschlägel Uta , Brendel Cornelia , Thrun Michael C.
Published: January 2024

Typical state-of-the-art flow cytometry data samples typically consist of measures of 10 to 30 features of more than 100,000 cell “events”. Artificial intelligence (AI) systems are able to diagnose such data with almost the same accuracy as human experts. However, such systems face one central challenge: their decisions have far-reaching consequences for the health and lives of people. Therefore, the decisions of AI systems need to be understandable and justifiable by humans. In this work, we present a novel explainable AI (XAI) method called algorithmic population descriptions (ALPODS), which is able to classify (diagnose) cases based on subpopulations in high-dimensional data. ALPODS is able to explain its decisions in a form that is understandable to human experts. For the identified subpopulations, fuzzy reasoning rules expressed in the typical language of domain experts are generated. A visualization method based on these rules allows human experts to understand the reasoning used by the AI system. A comparison with a selection of state-of-the-art XAI systems shows that ALPODS operates efficiently on known benchmark data and on everyday routine case data.
Numerical Investigation of Dimensionless Parameters in Carangiform Fish Swimming Hydrodynamics
Authors: Macías Marianela Machuca , García-Ortiz José Hermenegildo , Oliveira Taygoara Felamingo , Brasil Junior Antonio Cesar Pinho
Published: January 2024

Research into how fish and other aquatic organisms propel themselves offers valuable natural references for enhancing technology related to underwater devices like vehicles, propellers, and biomimetic robotics. Additionally, such research provides insights into fish evolution and ecological dynamics. This work carried out a numerical investigation of the most relevant dimensionless parameters in a fish swimming environment (Reynolds Re, Strouhal St, and Slip numbers) to provide valuable knowledge in terms of biomechanics behavior. Thus, a three-dimensional numerical study of the fish-like lambari, a BCF swimmer with carangiform kinematics, was conducted using the URANS approach with the k-ω-SST transition turbulence closure model in the OpenFOAM software. In this study, we initially reported the equilibrium Strouhal number, which is represented by St∗, and its dependence on the Reynolds number, denoted as Re. This was performed following a power–law relationship of St∝Re(−α). We also conducted a comprehensive analysis of the hydrodynamic forces and the effect of body undulation in fish on the production of swimming drag and thrust. Additionally, we computed propulsive and quasi-propulsive efficiencies, as well as examined the influence of the Reynolds number and Slip number on fish performance. Finally, we performed a vortex dynamics analysis, in which different wake configurations were revealed under variations of the dimensionless parameters St, Re, and Slip. Furthermore, we explored the relationship between the generation of a leading-edge vortex via the caudal fin and the peak thrust production within the motion cycle.
The miR-19a/Cylindromatosis Axis Regulates Pituitary Adenoma Bone Invasion by Promoting Osteoclast Differentiation
Authors: Lei Zhuowei , Wang Quanji , Jiang Qian , Liu Huiyong , Xu Linpeng , Kang Honglei , Li Feng , Huang Yimin , Lei Ting
Published: January 2024

Background: The presence of bone invasion in aggressive pituitary adenoma (PA) was found in our previous study, suggesting that PA cells may be involved in the process of osteoclastogenesis. miR-19a (as a key member of the miR-17-92 cluster) has been reported to activate the nuclear factor-кB (NF-кB) pathway and promote inflammation, which could be involved in the process of the bone invasion of pituitary adenoma. Methods: In this work, FISH was applied to detect miR-19a distribution in tissues from patients with PA. A model of bone invasion in PA was established, GH3 cells were transfected with miR-19a mimic, and the grade of osteoclastosis was detected by HE staining. qPCR was performed to determine the expression of miR-19a throughout the course of RANKL-induced osteoclastogenesis. After transfected with a miR-19a mimic, BMMs were treated with RANKL for the indicated time, and the osteoclast marker genes were detected by qPCR and Western Blot. Pit formation and F-actin ring assay were used to evaluate the function of osteoclast. The TargetScan database and GSEA were used to find the potential downstream of miR-19a, which was verified by Co-IP, Western Blot, and EMSA. Results: Here, we found that miR-19a expression levels were significantly correlated with the bone invasion of PA, both in clinical samples and animal models. The osteoclast formation prior to bone resorption was dramatically enhanced by miR-19, which was mediated by decreased cylindromatosis (CYLD) expression, increasing the K63 ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6). Consequently, miR-19a promotes osteoclastogenesis by the activation of the downstream NF-кB and mitogen-activated protein kinase (MAPK) pathways. Conclusions: To summarize, the results of this study indicate that PA-derived miR-19a promotes osteoclastogenesis by inhibiting CYLD expression and enhancing the activation of the NF-кB and MAPK pathways.
Common Misconceptions about Diet and Breast Cancer: An Unclear Issue to Dispel
Authors: Lalioti Anastasia , Verzeletti Laura , Tiberio Paola , Gerosa Riccardo , Gaudio Mariangela , Saltalamacchia Giuseppe , Pastore Manuela , Zambelli Alberto , Santoro Armando , De Sanctis Rita
Published: January 2024

Breast cancer (BC) constitutes a prevalent health condition among women. Recent years have witnessed the identification of dietary proto-oncogenic factors that deserve attention. Besides the well-known role of alcohol and red and processed meat in BC development, the impact of other dietary components remains unclear. Our narrative review aims to explore the diet-BC relationship, focusing on sugar, dairy, and soy consumption. We conducted a PubMed literature search covering the last decade (2013–2023) and included 35 papers. We found limited evidence on the association between high sugar intake and BC incidence. On the other hand, dairy and soy consumption displayed a protective effect in the majority of the analyzed papers. However, a significant degree of heterogeneity was reported among the results. Menopausal status and the specific BC molecular subtypes were the main factors influencing the interpretation of the results. Exploring dietary factors and BC revealed inconsistencies: high glycemic index post-menopause may be a risk factor, while sugar-sweetened drinks and artificial sweeteners yielded conflicting results; fermented dairy showed potential benefits, non-fermented dairy presented inconsistent findings; soy impact on BC varied according to molecular subtype, with some studies suggesting a positive association in luminal-like BC. Hence, further investigation is crucial to obtain a uniform consensus on the diet-BC relationship.
Histopathological Spectrum and Molecular Characterization of Liver Tumors in the Setting of Fontan-Associated Liver Disease
Authors: Francalanci Paola , Giovannoni Isabella , Tancredi Chantal , Gagliardi Maria Giulia , Palmieri Rosalinda , Brancaccio Gianluca , Spada Marco , Maggiore Giuseppe , Pietrobattista Andrea , Monti Lidia , Castellano Aurora , Giustiniani Maria Cristina , Onetti Muda Andrea , Alaggio Rita
Published: January 2024

Purpose: Univentricular heart is corrected with the Fontan procedure (FP). In the long term, so-called Fontan-associated liver diseases (FALDs) can develop. The aim of this study is to analyze the molecular profile of FALDs. Methods: FALDs between January 1990 and December 2022 were reviewed for histology and immunohistochemistry, laboratory data, and images. Targeted next generation sequencing (NGS), performed on the DNA and RNA of both neoplastic and non-lesional liver tissue, was applied. Results: A total of 31/208 nodules > 1 cm in diameter were identified on imaging, but a liver biopsy was available for five patient demonstrating the following: one hepatocellular adenoma (HA), two hepatocellular carcinomas (HCCs), one fibrolamellar carcinoma (FLC), and one intrahepatic cholangiocarcinoma (ICC). Molecular analysis showed a copy number alteration involving FGFR3 in three cases (two HCCs and one ICC) as well as one HCC with a hotspot mutation on the CTNNB1 and NRAS genes. Tumor mutational burden ranged from low to intermediate. A variant of uncertain significance in GNAS was present in two HCCs and in one ICC. The same molecular profile was observed in a non-lesional liver. A DNAJB1-PRKACA fusion was detected only in one FLC. Conclusions: Neoplastic FALDs show some unusual molecular profiles compared with non-Fontan ones. The presence of the same alterations in non-lesional cardiac cirrhosis could contribute to the development of FALD.
Importance of Diversity, Equity, and Inclusion in the Hepatopancreatobiliary Workforce
Authors: Rengers Timothy A. , Warner Susanne G.
Published: January 2024

Diversity is a catalyst for progress that prevents institutional stagnation and, by extension, averts descent to mediocrity. This review focuses on the available data concerning hepatopancreatobiliary (HPB) surgical workforce demographics and identifies evidence-based strategies that may enhance justice, equity, diversity, and inclusion for HPB surgeons and their patients. We report that the current United States HPB surgical workforce does not reflect the population it serves. We review data describing disparity-perpetuating hurdles confronting physicians from minority groups underrepresented in medicine at each stage of training. We further examine evidence showing widespread racial and socioeconomic disparities in HPB surgical care and review the effects of workforce diversity and physician–patient demographic concordance on healthcare outcomes. Evidence-based mitigators of structural racism and segregation are reviewed, including tailored interventions that can address social determinants of health toward the achievement of true excellence in HPB surgical care. Lastly, select evidence-based data driving surgical workforce solutions are reviewed, including intentional compensation plans, mentorship, and sponsorship.
Improving the Quality of Ceramic Products by Removing the Defective Surface Layer
Authors: Metel Alexander S. , Volosova Marina A. , Mustafaev Enver S. , Melnik Yury A. , Okunkova Anna A. , Grigoriev Sergey N.
Published: January 2024

The surface of ceramic products manufactured using diamond grinding is replete with shallow scratches, deep grooves and other defects. The thickness of the defective layer amounts to 3–4 µm and it must be removed to increase wear resistance of the products when exposed to intense thermomechanical loads. In this study, removal of the defective layers from samples made of ZrO2, Al2O3 and Si3N4 with a beam of fast argon atoms was carried out with a stripping rate of up to 5 µm/h. To prevent contamination of the source of fast argon atoms by the sputtered dielectric material, the beam was compressed and passed to the sample through a small hole in a wide screen. Due to the removal of the defective layer, abrasive wear decreased by an order of magnitude and the adhesion of coatings deposited on the cleaned ceramic surfaces improved significantly.
Psychometric Evaluation of the School Climate and School Identification Measure—Student on Chilean Students: A Bifactor Model Approach
Authors: Gálvez-Nieto José Luis , Trizano-Hermosilla Ítalo , Polanco-Levicán Karina
Published: January 2024

School climate is a relevant construct for understanding social relations at school. The SCASIM-St has been widely defined as a multidimensional construct; however, new factor structures have not been explored through evidence that allows for interpreting school climate scores from an approach that respects the multidimensionality of the scale and, at the same time, allows for identifying the degree of essential unidimensionality in the data. Consequently, the objective was to analyze the psychometric properties of the SCASIM-St from a bifactor model approach, evaluating the influence of a general school climate factor versus five specific factors. The study involved 1860 students of both sexes (42% males and 58% females), with an average age of 16.63 years (SD = 0.664), from 17 secondary schools in Chile. The results obtained by a confirmatory factor analysis provided evidence that the best model was the bifactor model for the 38 items, with one general factor and five specific factors. The Explained Common Variance (ECV) values and reliability levels by hierarchical omega accounted for a strong general school climate factor with high levels of reliability. Evidence of external criterion validity, assessed through the attitude toward authority scale (AIA-A), showed a theoretically expected and significant relationship between the factors of both instruments. This study confirmed the psychometric robustness of the SCASIM-St scale by means of a bifactor model, allowing for a new, essentially unidimensional interpretation of the scale scores and providing an instrument to measure school climate in Chile.
How Do Children “Think outside the Box”? Fluid Intelligence and Divergent Thinking: A Moderated Mediation Study of Field Dependent-Independent Cognitive Style and Gender
Authors: Giancola Marco , Palmiero Massimiliano , Pino Maria Chiara , Sannino Marta , D’Amico Simonetta
Published: January 2024

The interplay between fluid intelligence (Gf) and divergent thinking (DT) has widely characterized current research in the psychology of creativity. Nevertheless, the evidence on the main factors involved in this association during childhood remains a matter of debate. Present research has addressed the interplay between Gf and DT, exploring the mediating role of a field dependent-independent cognitive style (FDI) and the moderating effect of gender in 101 children (Mage = 8.02; SDage = 1.43). Participants carried out Raven’s Colored Progressive Matrices, the Children Embedded Figure Test, and the Alternative Uses Task. The results revealed the mediating effect of FDI in the association between Gf and DT, providing evidence that this cognitive style represents a function of controlled mental processes underpinned by Gf, which are useful to thinking divergently. In addition, the findings reported that the interplay between FDI and DT was moderated by gender, suggesting that the impact of FDI on DT was stronger among boys. Through a multidimensional approach, these current research findings provide further insight into the primary children’s factors involved in the ability to find alternative solutions and think divergently.
Navigating the Complex Landscape of Economic Research Concerning Commodities
Authors: Baek Jungho
Published: January 2024

As we delve into the realm of economic research concerning commodities, it becomes increasingly evident that the contemporary world is marked by constant change and evolving dynamics [...]
Adaptive Forecasting in Energy Consumption: A Bibliometric Analysis and Review
Authors: Jaramillo Manuel , Pavón Wilson , Jaramillo Lisbeth
Published: January 2024

This paper addresses the challenges in forecasting electrical energy in the current era of renewable energy integration. It reviews advanced adaptive forecasting methodologies while also analyzing the evolution of research in this field through bibliometric analysis. The review highlights the key contributions and limitations of current models with an emphasis on the challenges of traditional methods. The analysis reveals that Long Short-Term Memory (LSTM) networks, optimization techniques, and deep learning have the potential to model the dynamic nature of energy consumption, but they also have higher computational demands and data requirements. This review aims to offer a balanced view of current advancements and challenges in forecasting methods, guiding researchers, policymakers, and industry experts. It advocates for collaborative innovation in adaptive methodologies to enhance forecasting accuracy and support the development of resilient, sustainable energy systems.
Enhancement of Fatigue Life of Polylactic Acid Components through Post-Printing Heat Treatment
Authors: Jimenez-Martinez Moises , Varela-Soriano Julio , Carrera-Espinoza Rafael , Torres-Cedillo Sergio G. , Cortés-Pérez Jacinto
Published: January 2024

To reduce the carbon footprint of manufacturing processes, it is necessary to reduce the number of stages in the development process. To this end, integrating additive manufacturing processes with three-dimensional (3D) printing makes it possible to eliminate the need to use tooling for component manufacturing. Furthermore, using 3D printing allows the generation of complex models to optimize different components, reducing the development time and realizing lightweight structures that can be applied in different industries, such as the mobility industry. Printing process parameters have been studied to improve the mechanical properties of printed items. In this regard, although the failure of most structural components occurs under dynamic load, the majority of the evaluations are quasistatic. This work highlights an improvement in fatigue strength under dynamic loads in 3D-printed components through heat treatment. The fatigue resistance was improved regarding the number of cycles and the dispersion of results. This allows 3D-printed polylactic acid components to be structurally used, and increasing their reliability allows their evolution from a prototype to a functional component.
Optical Genome Mapping for Chromosomal Aberrations Detection—False-Negative Results and Contributing Factors
Authors: Xu Yiyun , Zhang Qinxin , Wang Yan , Zhou Ran , Ji Xiuqing , Meng Lulu , Luo Chunyu , Liu An , Jiao Jiao , Chen Hao , Zeng Huasha , Hu Ping , Xu Zhengfeng
Published: January 2024

Optical genome mapping (OGM) has been known as an all-in-one technology for chromosomal aberration detection. However, there are also aberrations beyond the detection range of OGM. This study aimed to report the aberrations missed by OGM and analyze the contributing factors. OGM was performed by taking both GRCh37 and GRCh38 as reference genomes. The OGM results were analyzed in blinded fashion and compared to standard assays. Quality control (QC) metrics, sample types, reference genome, effective coverage and classes and locations of aberrations were then analyzed. In total, 154 clinically reported variations from 123 samples were investigated. OGM failed to detect 10 (6.5%, 10/154) aberrations with GRCh37 assembly, including five copy number variations (CNVs), two submicroscopic balanced translocations, two pericentric inversion and one isochromosome (mosaicism). All the samples passed pre-analytical and analytical QC. With GRCh38 assembly, the false-negative rate of OGM fell to 4.5% (7/154). The breakpoints of the CNVs, balanced translocations and inversions undetected by OGM were located in segmental duplication (SD) regions or regions with no DLE-1 label. In conclusion, besides variations with centromeric breakpoints, structural variations (SVs) with breakpoints located in large repetitive sequences may also be missed by OGM. GRCh38 is recommended as the reference genome when OGM is performed. Our results highlight the necessity of fully understanding the detection range and limitation of OGM in clinical practice.
An Optimization Method for the Distributed Collaborative Operation of Multilateral Entities Considering Dynamic Time-of-Use Electricity Price in Active Distribution Network
Authors: Liang Gang , Wang Yu , Sun Bing , Zhang Zheng
Published: January 2024

More and more microgrids, energy storage systems, and other emerging entities are integrated into active distribution networks. However, a microgrid is characterized by autonomous operation and privacy protection. The rapid development of equipment such as shared energy storage brings strong uncertainty to a traditional dispatcher. The observability and controllability of the distribution system decrease, and traditional regulatory methods are no longer applicable. To deal with the above challenges, a distributed collaborative operation optimization method of multilateral participants is proposed. Guided by the dynamic time-of-use electricity price, the collaborative operation of multilateral participants can be realized. Firstly, the cooperative operation architecture is established considering the dynamic time-of-use electricity price. In this architecture, the residual capacity of shared energy storage is used for arbitrage by storing electricity at low electricity prices and generating electricity at high electricity prices. Then, the optimization operation models of a microgrid alliance, shared energy storage, and an active distribution network are established. The final operation scheme and the dynamic time-of-use price of the distribution network are formulated through the cyclic iteration among the three participants. Finally, a case study is carried out to analyze the optimization effect of each participant with the proposed method. It is found that the overall interests and the interests of each participant can be taken into account effectively and the consumption of renewable energy can be promoted by the method proposed in the paper. In addition, an oscillation phenomenon is found during the distributed collaborative operation, and the strategy to eliminate the oscillation phenomenon is given.
Problems during the Design and Testing of Instrument, Special and Power Transformers: The Outlook
Authors: Lesniewska Elzbieta , Witczak Pawel
Published: January 2024

In 1831, Michael Faraday discovered the phenomenon of electromagnetic induction, which allowed for the construction of previously unknown electrical devices and significantly impacted economic and social development [...]
Restoration of Aegiceras corniculatum Mangroves May Not Increase the Sediment Carbon, Nitrogen, and Phosphorus Stocks in Southeastern China
Authors: Hu Naxu , Wei Long , Zhou Yi , Wu Meilin , Feng Jianxiang
Published: January 2024

Mangrove ecosystems play important roles in mitigating climate change but are suffering from an area decrease. The sediment in a mangrove ecosystem is a crucial component in estuarine carbon and nutrient cycles. However, it is unclear whether the restoration of mangroves enhances their sediment carbon sequestration and nutrient storage. To investigate the restoration effects of native Aegiceras corniculatum mangrove forests, the contents and density of sediment organic carbon (SOC), total nitrogen (TN), and total phosphorus (TP) were quantified in an unvegetated mudflat (MF), an area with mature A. corniculatum (AC), and two restored A. corniculatum mangroves planted in 2002 (02AC) and 2008 (08AC) in Quanzhou, southeastern China. Compared with the MF, mangrove restoration increased the SOC and TN contents in the sediment, primarily at the 0–40 cm depth for SOC and 0–20 cm for TN, while the TP content was not impacted by restoration. The sediment under AC showed a higher SOC content only at the 0–10 cm and 20–40 cm depths compared to restored 02AC and 08AC. The restoration of A. corniculatum mangroves did not significantly increase the stock of sediment SOC, TN, and TP relative to the MF, which might be attributed to the decrease in bulk density and the relatively short restoration period. Thus, further continuous monitoring is needed to verify whether the sediment carbon pool can be promoted on a longer-term scale by the restoration of A. corniculatum.
Revealing Three-Dimensional Variations in Fuel Structures in Subtropical Forests through Backpack Laser Scanning
Authors: Kang Ping , Lin Shitao , Huang Chao , Li Shun , Wu Zhiwei , Sun Long
Published: January 2024

Wildfire hazard is a prominent issue in subtropical forests as climate change and extreme drought events increase in frequency. Stand-level fuel load and forest structure are determinants of forest fire occurrence and spread. However, current fuel management often lacks detailed vertical fuel distribution, limiting accurate fire risk assessment and effective fuel policy implementation. In this study, backpack laser scanning (BLS) is used to estimate several 3D structural parameters, including canopy height, crown base height, canopy volume, stand density, vegetation area index (VAI), and vegetation coverage, to characterize the fuel structure characteristics and vertical density distribution variation in different stands of subtropical forests in China. Through standard measurement using BLS point cloud data, we found that canopy height, crown base height, stand density, and VAI in the lower and middle-height strata differed significantly among stand types. Compared to vegetation coverage, the LiDAR-derived VAI can better show significant stratified changes in fuel density in the vertical direction among stand types. Among stand types, conifer-broadleaf mixed forest and C. lanceolata had a higher VAI in surface strata than other stand types, while P. massoniana and conifer-broadleaf mixed forests were particularly unique in having a higher VAI in the lower and middle-height strata, corresponding to the higher surface fuel and ladder fuel in the stand, respectively. To provide more informative support for forest fuel management, BLS LiDAR data combined with other remote sensing data were advocated to facilitate the visualization of fuel density distribution and the development of fire risk assessment.
Blockchain-Based Implementation of National Census as a Supplementary Instrument for Enhanced Transparency, Accountability, Privacy, and Security
Authors: Rasheed Sana , Louca Soulla
Published: January 2024

A national population census is instrumental in offering a holistic view of a country’s progress, directly influencing policy formulation and strategic planning. Potential flaws in the census system can have detrimental impacts on national development. Our prior research has pinpointed various deficiencies in current census methodologies, including inadequate population coverage, racial and ethnic discrimination, and challenges related to data privacy, security, and distribution. This study aims to address the “missing persons” challenge in the national census population and housing system. The integration of blockchain technology emerges as a promising solution for addressing these identified issues, enhancing the integrity and efficacy of census processes. Building upon our earlier research which examined the national census system of Pakistan, we propose an architecture design incorporating Hyperledger Fabric, performing system sizing for the entire nation count. The Blockchain-Based Implementation of National Census as a Supplementary Instrument for Enhanced Transparency, Accountability, Privacy, and Security (BINC-TAPS) seeks to provide a robust, transparent, scalable, immutable, and tamper-proof solution for conducting national population and housing censuses, while also fostering socio-economic advancements. This paper presents a comprehensive overview of our research, with a primary focus on the implementation of the blockchain-based proposed solution, including prototype testing and the resulting outcomes.
Explosive Characteristics Analysis of Gasoline–Air Mixtures within Horizontal Oil Tanks
Authors: Jiang Xinsheng , Zhou Dongliang , Zhang Peili , Cai Yunxiong , Chen Ri , He Donghai , Qin Xizhuo , Lin Keyu , Wang Sai
Published: January 2024

Horizontal oil tanks, like other oil storage containers, carry the risk of explosion when gasoline–air mixtures are ignited. With the widespread application of horizontal oil tanks in the petrochemical industry, attention to safety risks is increasing. However, currently, a limited amount of experimental research on such tanks exists. To explore the characteristics of gasoline–air mixtures combustion within the confined space of horizontal oil tanks, this study constructed a medium-scale simulated horizontal oil tank (L/D = 3, V = 1.0 m3) platform. By investigating the effects of different initial gasoline–air mixture volume fractions and ignition positions on explosion overpressure characteristic parameters, an analysis of the combustion characteristics was conducted. It was found that the most dangerous gasoline–air mixture volume fraction is 1.9% when ignited at the top position and 2.1% at the middle. It was also observed that the ignition position has a significant impact on the variation in explosion overpressure characteristic parameters, with ignition at the middle position resulting having a greater explosive force compared to ignition at the top position. Furthermore, using ignition at the middle position as an example, a study was conducted on the flame morphology characteristics at initial gasoline–air mixture volume fractions of 1.1%, 1.9%, and 2.7%. The conclusions from this research deepen our understanding of the explosion characteristics of different containers, providing theoretical insights for the safe storage and transportation of oil materials in horizontal oil tanks.
Calibration of Thixotropic and Viscoelastic Shear-Thinning Fluids Using Pipe Rheometer Measurements
Authors: Cayeux Eric
Published: January 2024

Some non-Newtonian fluids have time-dependent rheological properties like a shear stress that depends on the shear history or a stress overshoot that is a function of the resting time, when fluid movement is started. The rheological properties of such complex fluids may not stay constant while they are used in an industrial process, and it is therefore desirable to measure these properties frequently and with a simple and robust device like a pipe rheometer. This paper investigated how the time-dependent rheological properties of a thixotropic and viscoelastic shear-thinning fluid can be extracted from differential pressure measurements obtained at different flowrates along a circular pipe section. The method consists in modeling the flow of a thixotropic version of a Quemada fluid and solving the inverse problem in order to find the model parameters using the measurements made in steady-state conditions. Also, a Maxwell linear viscoelastic model was used to reproduce the stress overshoot observed when starting circulation after a resting period. The pipe rheometer was designed to have the proper features necessary to exhibit the thixotropic and viscoelastic effects that were needed to calibrate the rheological model parameters. The accuracy of rheological measurements depends on understanding the effects that can influence the observations and on a proper design that takes advantage of these side effects instead of attempting to eliminate them.
Facile Synthesis of Carbon-Based Inks to Develop Metal-Free ORR Electrocatalysts for Electro-Fenton Removal of Amoxicillin
Authors: Valencia-Valero Laura Carolina , Fajardo-Puerto Edgar , Elmouwahidi Abdelhakim , Bailón-García Esther , Carrasco-Marín Francisco , Pérez-Cadenas Agustín Francisco
Published: January 2024

The electro-Fenton process is based on the generation of hydroxyl radicals (OH•) from hydroxide peroxide (H2O2) generated in situ by an oxygen reduction reaction (ORR). Catalysts based on carbon gels have aroused the interest of researchers as ORR catalysts due to their textural, chemical and even electrical properties. In this work, we synthesized metal-free electrocatalysts based on carbon gels doped with graphene oxide, which were conformed to a working electrode. The catalysts were prepared from organic-gel-based inks using painted (brush) and screen-printed methods free of binders. These new methods of electrode preparation were compared with the conventional pasted method on graphite supports using a binder. All these materials were tested for the electro-Fenton degradation of amoxicillin using a homemade magnetite coated with carbon (Fe3O4/C) as a Fenton catalyst. All catalysts showed very good behavior, but the one prepared by ink painting (brush) was the best one. The degradation of amoxicillin was close to 90% under optimal conditions ([Fe3O4/C] = 100 mg L−1, −0.55 V) with the catalyst prepared using the painted method with a brush, which had 14.59 mA cm−2 as JK and a H2O2 electrogeneration close to 100% at the optimal voltage. These results show that carbon-gel-based electrocatalysts are not only very good at this type of application but can be adhered to graphite free of binders, thus enhancing all their catalytic properties.
Agar and Chitosan Hydrogels’ Design for Metal-Uptaking Treatments
Authors: Cuvillier Luana , Passaretti Arianna , Guilminot Elodie , Joseph Edith
Published: January 2024

In the field of cultural heritage, the use of natural gels is rising for the application of active agents. Here, two natural polymers are assessed: agar, a pioneer hydrogel for conservation treatments, and chitosan, a rather novel and metal-binding gel. For chitosan, a state-of-the-art based formulation (CS–ItA–LCys) is evaluated as it was reported for silver-complexing properties. It is evaluated whether these polymers can withstand the addition of the chelating compound deferoxamine, which is a bacterial siderophore. This allows for the obtainment of completely bio-sourced gel systems. A Fourier-transformed (FT) infrared spectroscopy characterization is performed, completed with rheological measurements and Cryo-Scanning Electron Microscopy (cryo–SEM) to investigate the physico–chemical properties of the gels, as well as their interaction with deferoxamine. Both polymers are also tested for their inherent complexing ability on silver ions using FT–Raman spectroscopy. A multi-analytical comparison shows different microstructures, in particular, the presence of a thick membrane for chitosan and different mechanical behaviors, with agar being more brittle. Neither hydrogel seems affected by the addition of deferoxamine; this is shown by similar rheological behavior and molecular structures in the presence or absence of the chelator. The intrinsic abilities of the chitosan formulation to make silver complex are demonstrated with the observation of two peaks characteristic of Ag–S and Ag–O bonds. Agar and chitosan are both proven to be reliable gels to act as carriers for bio-based active agents. This paper confirms the potential asset of the chitosan formulation CS–ItA–LCys as a promising gel for the complexation of soluble silver.