bluuebunny/crossref_metadata_2025 huggingface dataset:
Russian Size Adjectives Analyses by Corpus Linguistics Methods
Authors: Gizatullina Azaliya Rishatovna , Lutfullina Gulnara Firdavisovna , Yulievna Tameryan Tatiana
Published: June 2023

The paper analyzes the functioning of size adjectives, exact as well as average size adjectives in Russian. Accurate measurement requires a numeral and also an adjective corresponding to the unit of measure. A parametric adjective is non-obligatory, while the designated parameter is derived from the semantics of the defined noun. The parametric noun in the required case form is included in the noun group, which performs the function of the attribute. Average size adjectives with abstract parameter nouns form complex attributes, taking pre and post positions to the defined noun. The adjective cредний /average is mainly combined with height and length parameters with the dominance of the noun size. Size adjectives короткий / short and длинный / long have a 2.4 asymmetrical ratio index of their functioning. It should be noted that roads and streets are more often characterized by positive and negative parameters, in turn. Adjectives of a positive width parameter dominate in garment characterization. This survey's primary objective is a qualitative analysis of the structure and semantics of size adjectives of exact measurement.
Risks of Small and Medium-Sized Businesses Attracting to Government and Municipal Procurement and Economic Growth
Authors: Khayrullova A.I. , Sabitova N.M. , Khafizova A.R. , Nasyrova V. I.
Published: June 2023

One of the strategic goals in the Russian Federation is to relieve social tension by increasing the number of people employed in the segment of small and medium enterprises (hereinafter - SMEs) up to 25 million people by 2024. In order to stimulate the development of this segment, the Government of the Russian Federation sets the task of expanding the access for SMEs to the procurement system. That’s why the analysis of the existing mechanism for attracting SMEs to procurement is of interest. The primary purpose of the study is to investigate the peculiarities of SME involvement in procurement within the framework of two main laws operating in the sphere of procurement activity and problems arising in the procurement’s organization and economic growth. The practice of procurement activity is accompanied by the emergence of risks that affect the procurement result. These risks are inherent both to customers and suppliers of procurement activities. In the article risks are classified by stages of procurement activity. In particular, risks of poor-quality performance of the contract arise long before the stage of its conclusion. In the conclusion, recommendations are made which can be directed to solving the issues of SMEs access to procurement.
Use of Economic and Mathematical Modeling Tools in Planning Investments in Fixed Assets
Authors: Kulikova Lidiya , Aminova Diana , Lyzhova Anna
Published: June 2023

In order to maximize the effectiveness of fixed assets use it is necessary to assess the impact of organizational factors on capital productivity of fixed assets, and also to assess the feasibility of capital investment in fixed assets. The purposes of the study are to design an economic-mathematical model that makes it possible to predict a value of capital productivity knowing the values of different factors, as well as to calculate the effectiveness of capital investment in fixed assets on the example of the regional branch of Tatarstan Energy Company. During the correlation and regression analysis of the Tatarstan energy company branch, the authors found that the cost of the active part of fixed assets has the greatest impact on the capital productivity of fixed assets, so the company is recommended to increase the active part of fixed assets. The proposed approach to scenario forecasting of capital investments in fixed assets allows to assess the prospects for changes in the company's financial performance as a result indicator of the company's performance.
Turkish World and Literary Relations of the East
Authors: Minnegalieva Aigul Ildusovna , Mingazova Liailia Ihsanovna , Ibrayeva Aigerim Tarbinovna , Kayumova Gelyusya Faridovna
Published: June 2023

All Turkic literature has a common cultural framework. A substantial confirmation of this fact comes from the national spiritual heritage, which has become the basis for the further development and flourishing of the verbal art of Turkic peoples. First of all, these are Китабы Деде Коркут of the Oghuz, the Kyrgyz heroic epos Манас (Manas), Идегей (Idegei) – the variants of which were widespread among the Kazakhs and the Tatars, the famous Чура батыр (Chura Batyr) among the Tatars, etc. The works such as A Thousand Nights and a Night (Мың бір түн), Shakhname or Shakh-Name (Шахнама), Kalila and Dimna (Кәлила мен Димна), Leili and Majnun (Ләйлі-Мәжнүн), Zhusip-Zylikha (Жүсіп-Зылиха), Takhir-Zukhra, Farkhad-Shyryn or Khosrov-Shyryn (Хұсрау-Шырын) have exerted a significant influence on the development of literature. The article concludes that, despite the national differences of the Turkic peoples, they are united by common literary background, common goals, and interests, moral, spiritual, and cultural values. It is proved out again that the literature of the Turkic peoples is abundant in authors and works, characterized by a variety of genres and poetic forms, ideological and thematic wealth, and a high artistic level. Emphasis is also put on the fact that in the eastern tradition, there are many samples of word-of-mouth literature of the general plot and cultural heritage of the Turkic peoples who had inhabited the eastern lands since ancient centuries.
Mythological Thinking and Philosophy
Authors: Vladimirovich Kondratiev Konstantin
Published: June 2023

The article's primary purpose is to analyze the problems of the emergence of philosophy against the background of myth and the correlation of mythical and philosophical styles of thinking. The author substantiates the question of myth theories that do not consider the bearer's inner conviction of mythological thinking in the absolute reality of events and characters described in myths. The main features of the myth as the most ancient form of social consciousness are revealed: absolute subjective certainty, anonymity, which is expressed in an unconscious type of authorship, as well as a specific explanatory function, the essence of which is to implement the solution for a cognitive task before this task itself can be set and consciously formulated. Myth cannot be considered pre-scientific thinking, as an early form of folk art, or as primitive forms of religious worship. The crisis of mythology, which consists of its inability to perform its explanatory function, in turn, generates three new types of social consciousness: epic and other types of the poetry of personal authorship, religious teachings as a system of dogmas and organized cult actions, propagated by the prophets and supported by the priests, and philosophical thinking as a form of conscious intellectual creativity, the reliability of the results of which is supported by the personal wisdom of its author.
Tendency of Investment Economy Formation
Authors: Battalova Alina R. , Tukhvatullin Ruslan Sh. , Mukhametgaliev Farit N. , Mukhametgalieva Farida F. , Sitdikova Landish F.
Published: June 2023

The relevance of the topic is caused by the need to identify trends and characteristics of the investment economy formation in the face of the external economic environment new challenges. The article’s main aim is to develop recommendations for optimizing the directions of the state economic policy in the field of investment activity development. The research is based on an analysis of the current situation and the identification of trends in the formation of Russia's investment economy and its regions. The study's novelty is to identify trends and characteristics in the investment economy formation in the regions of Russia and formulate development sectors in the Republic of Tatarstan. The main results of the study are as follows: issues of the preconditions for the formation of investment activity in the country's economy are examined, as well as macroeconomic indicators that form the financial foundations of the investment economy, the main directions for improving investment attractiveness are identified and proposed, including the use of the advantages of geographical and geopolitical position, increasing the economic, social and political level of development, improving the state of the environmental situation and demographic situation.
Deviation of Phraseological Unit Semantic Stability as a Means of Phraseological Transformation
Authors: Mirgalimova Liliia Marselevna , Arsenteva Elena Fridrikhovna , Nikulina Elena Aleksandrovna
Published: June 2023

The article is devoted to discussing transformed phraseological units based on the American government blog materials. The theoretic part of the work touches upon the question of terminology. The authors study the existing approaches to fixedness (stability, irregularity, occasional use, modifications) of phraseological units. We seek to analyze the modified variants of phraseological units, describe mechanisms of transformations, and provide their translations. Special attention is devoted to deviations of semantic stability within the structure of phraseological units and modifications that appear when deviations occur. The analysis of the examples will provide a better understanding of the process which is being discussed. Among the mechanisms that trigger transformations, we distinguish between metonymy, polysemy, and context, making modifications within the principle of semantic fixedness, among them reconsideration of phraseological unit meaning and literalization of meaning. Finally, in terms of semantic fixedness, we will define two possible variants of phraseological units' transformations.
Technical and Economic Indicators of Strategic Management Accounting in the Development Companies Based on the Life Cycle of the Produce
Authors: Akhmetzianov Ainur A. , Sokolov Andrew Y.
Published: June 2023

This article discusses the issues of technical and economic indicators of strategic management of a development company and the application of modern management accounting methods. We have analyzed various scientific studies of scientists in the field of product life cycle management and it was found that now this area is very popular and there is a demand for it from modern companies. In that reason for effective control and project planning, it has been proposed to use the Life Cycle Costing method, which can be successfully applied to development. This system was supplemented by the method of Target Costing, which is used for the target cost management. Using this method, the target price was determined, which was used to determine the acceptable margin of the development project at the planning stage. An interaction scheme of responsibility centers was proposed in order to achieve the implementation and effective operation of these systems, which allowed to reduce costs and accelerate sales. Using this proposal, it was possible to reduce design errors that led to significant additional costs.
Modern Trends in Mediatisation of Culture in a Digital Society
Authors: Baigozhina Dana O. , Ibrayeva Elmira E. , Duisengazy Serikzat M. , Takhan Serik Sh. , Zhanysbayeva Akniyet P.
Published: June 2023

The establishment of a new dominant technological order is caused by the growth dynamics of the digital media space – an important component of the global media space, the development of which is a natural stage in the era of electronic communications. The media space is a sophisticated self-organising system and is a part, a subsystem of the information and communication universe as a set of all systems, one way or another related to communication processes. The novelty of the study is determined by the postulate that the media space constitutes a component of the global space of social life of people, generates and organises the production and consumption of information in various forms of social communication; this is a special reality. The authors show that its development is facilitated by the growth of the variety of communication technologies that accompanied the historical and cultural development of society. The paper shows that the media space is described by several components that determine social life: the technosphere built on information and communication technology; an infosphere based on information network highways; socio-infosphere, which includes information flows and organised structures that control the processes of their creation and consumption and affect the state of social intelligence. The practical significance of the study is that the media space is not only a retransmitter of information, but also its producer, in connection with which it acts as a complex, global system that contains all socio-cultural components capable of developing information prerequisites and requests and catering to the information needs by all possible communication means.
Equity in Admissions Policies of Undergraduate Students in Post Democracy in Selected South African Universities
Authors: Matsepe David , Cross Michael , Fenyane Samuel
Published: June 2023

This paper investigates the policy pathways that inform and regulate student selection and admission at three selected universities in South Africa, namely the University of the Witwatersrand, the University of Cape Town and the University of KwaZulu-Natal. We argue that these universities have progressed a long way in addressing the race problem in their enrolment strategies. However, their main target group remains students from rich or affluent communities, to the exclusion of potentially good students from marginalised groups, particularly those from under-resourced township and rural schools. As a result, their main challenge in the context of formal access to higher education in South Africa has largely shifted from a race problem to one of social class. This is due to an overemphasis on narrow conceptions of merit that cannot be reconciled with equity and social justice concerns. The paper suggests that current notions of merit warrant reconceptualization in order to embrace these missing dimensions. While there is plenty of evidence that most institutions agree on the need to embrace a particular form of affirmative action to address current social imbalances, given the fierce contestation of redress policies within the South African higher education sector, they find it difficult to develop and implement adequate admission strategies in practice.
Climate Change, Environment and Armed Conflicts in Nigeria
Authors: Kelechi Johnmary Ani Kelechi , Emmanuel Uwizeyimana Dominique
Published: June 2023

Climate change has become a major cause of conflicts in Nigeria, which directly causes multiple forms of insecurity in the country. In different parts of the globe, it manifests as earth quake, hurricane, tsunami, etc. Nigeria has received its share of climate change both in two opposite forms. In the southern coastal states of Lagos, Bayelsa, and Rivers State, the ocean and overflowing waters continually threatens to wipe away the people. However, this study focuses on the north and parts of southern Nigeria, where the impact of climate change has generated armed conflict. The study which used qualitative methodology traced how climate change and the emergence of drought, famine and other forms of environmental changes leads to resource competition over land, mineral resource, water ways and by extension generating armed conflicts in many parts of Nigeria. It found that climate change caused mass migration and the settler versus non-settler conflicts that manifested in different as herdsmen-farmer conflict, as well as the armed conflict among the Ezza and her neighbours and also contributed to the Ife-Modakeke crisis in the country. Finally, the study documents multi-dimensional road-map to environmental peace and adaptations for sustainable societal development.
The Influence of National Economy Specifics on the Interaction between Universities and Corporations in the Field of Innovation
Authors: G. Gribov Pavel , L. Lomakin Andrey , Ya. Kurganskaya Marina , Z. Kumelashvili Maria
Published: June 2023

Questions of the influence of national economy features on innovation activity do not lose their relevance at the beginning of the XXI century. In different countries of the world, new approaches to stimulating innovation are emerging that take into account the peculiarities of national economies. However, the main problem of such activities remains the speed of movement of new technologies from universities to corporations and the further creation of new products and technologies. The number of patents obtained by various organizations is becoming one of the main indicators of the development of the national economy. It is noted that the relationship between research costs and the number of patents obtained is not as linear as it seems in theory. The practical implementation of diffuse processes in an innovative environment also does not have a linear dependence on the "investment – result".
The use of statistical analysis methods allowed us to identify the facts that signal that the model of stimulating innovation activity, formed in the 1980s of the XX century, is losing its advantages. The article examines in detail the progress of higher education reform in the EU countries and identifies the key features of combining scientific organizations to create large multidisciplinary research centers. The authors conclude that the experience of such a reform in France is very interesting to study in Russia. It is noted that since the 2000s. in the United States and the European Union, questions are raised about the revision of the University tax system, as well as changes in the legal status of educational organizations. Similar trends occur in Russia, however, due to historical and social processes, they have their specifics. According to the authors, the regulation of taxation of scientific activities leads to the formation of unique elements of the economic mechanism for stimulating innovation.
The Impact of Gender Identity on In-Group Trust
Authors: Danyliuk Ivan , Trofimov Andrii , Vovk Mariia , Zelenko Oleksandr , Kutsenko Yana , Prosina Olha
Published: June 2023

The article discusses the problem of the influence of gender identity on intra-group trust. Various scientific views on the category of trust are examined. Attention is also paid to the socio-psychological function of trust. Trust, in turn, is the foundation of the relationship between people and a factor in the effectiveness of cooperation. Having defined gender identity, we can say which form of identification positively affects internal group trust, and therefore the effectiveness of cooperation in a sports team. The article describes what type of gender identification (masculinity, femininity, androgyny) positively affects internal group trust, and does this have any connection with the success of a sports team. Also in the article to answer our tasks: 1) conduct a theoretical analysis of foreign and domestic theories of the formation of gender identity; 2) to study the theoretical foundations of the phenomenon of trust and analyze the importance of trust as a component of interpersonal communication in a sports team; 3) conduct a study to determine the gender identity of the person and determine the level of trust in the sports team; 4) analyze the relationship between gender identity and trust in a sports team; 5) to trace the influence of these factors on the success of a football team.
Tips for Writing a Research Protocol
Authors: Faiman, PhD, MSN, APRN-BC, AOCN, BMTCN, FAAN, FAPO Beth
Published: June 2023

A brilliant advanced practitioner colleague, whose article you will find in this issue, asked whether JADPRO would publish her successfully funded grant application. When I asked about her motivation to become a researcher and seek grant funding after years of a successful clinical career, she had the most astonishing reply. “Physicians can be physician scientists, and I wanted to be a nurse practitioner scientist.” Her motivation made me wonder how many other advanced practitioners (APs) share the same desire: To strike a balance between conducting innovative research and maintaining patient care responsibilities. Indeed, her career path seemed remarkably similar to mine.
Research Strategy for the Development of a Quality-of-Life Decision-Making Model for Older Patients With Acute Myeloid Leukemia
Authors: M. Tinsely-Vance, PhD, APRN, AOCN Sara
Published: June 2023

Acute myeloid leukemia (AML) is a deadly cancer, especially for patients over 60 years of age who face the dilemma of choosing the best treatment during a time of crisis. Current research in the older AML population is focused on survival without addressing quality of life (QOL). Survival and QOL data are essential for patients to decide which treatment best aligns with their goals, whether for survival or improved QOL. Research aims: The aims of this study are to: (1) Describe differences in QOL among newly diagnosed older AML patients receiving intensive chemotherapy compared with nonintensive chemotherapy (at baseline, and days 30, 60, 90, and 180 post treatment); (2) Identify the individual clinical disease characteristics and patient factors of newly diagnosed AML patients that predict QOL among those receiving two treatment intensities; and (3) Design a patient decision-making model that integrates the significant clinical disease and patient factor predictors of QOL for newly diagnosed older AML patients. Methods: An exploratory observational design will be used to address aims 1 and 2. Data will be collected from 200 patients ≥ 60 years of age with newly diagnosed AML. Subjects will complete the Functional Assessment of Cancer Therapy-Leukemia, Brief Fatigue Inventory, and Memorial Symptom Assessment Short Form within 7 days of beginning new treatment and at days 30, 60, 90 and 180. Clinical disease characteristics will be completed by the health-care team. A patient decision-making model will be developed to provide survival and quality-of-life data for intensive and nonintensive chemotherapy.
Management of Patients With Advanced Gastrointestinal Stromal Tumor: Emphasis on Fourth-Line Treatment With Ripretinib
Authors: Brackert, NP Sandra , Polson, NP Kathleen
Published: June 2023

Gastrointestinal stromal tumors (GISTs) are considered rare, yet they represent the most common sarcomas of the gastrointestinal tract. The development of tyrosine kinase inhibitors (TKI) for the treatment of GISTs changed the way we treat patients and has greatly impacted outcomes. However, most patients who initially benefit from TKIs eventually develop disease progression and require subsequent therapies. Ripretinib is a switch-control TKI approved for the treatment of adult patients with advanced GIST who received prior treatment with three or more TKIs, including imatinib. Our objective was to review existing treatment options for patients with advanced GIST, focusing on management optimization for heavily pretreated patients receiving ripretinib. With the integration of ripretinib as a fourth-line therapy, the GIST treatment landscape continues to evolve. As the treatment paradigm becomes increasingly complex, successful management of adverse events and individualized supportive care remain crucial to maintaining effective treatment and patient quality of life. Additionally, we present a detailed case study of a heavily pretreated patient with advanced GIST who received ripretinib as fourth-line therapy. The information provided here should help inform advanced practitioners on the effective management of patients with GIST who have progressed on multiple therapies. Advanced practitioners are well positioned to provide the necessary supportive care to achieve optimal outcomes and drug compliance.
Efectos del ayuno intermitente sobre el rendimiento y la composición corporal de los deportistas. Revisión sistemática
Authors: Tejada-Medina Virginia , Domínguez Ramírez Daniel , Martín-Moya Ricardo
Published: June 2023

The practice of intermittent fasting is a current topic that has been making its way into the dietary landscape in recent years. The purpose of this literature review was to analyse the effects of intermittent fasting in conjunction with physical activity on the performance and body composition of athletes. The search was carried out in the Web of Science and Scopus databases, using the descriptors «intermittent fasting» y «intermittent dietary intake». Of the 246 results initially obtained, 20 met the inclusion criteria and were selected for this study. The articles analysed focus mainly on the use of intermittent fasting and physical exercise to improve performance and body composition. Upon analysis, we found findings consistent with national and international literature regarding the benefits of intermittent fasting. In conclusion, intermittent fasting, together with physical activity, favours the loss of fat mass and, consequently, body weight, as well as improving health-related biomarkers. However, all the scientific literature reviewed suggests the need for further studies to reinforce these conclusions.

La práctica del ayuno intermitente es una temática actual que en los últimos años se está haciendo hueco en el panorama dietético. El propósito de esta revisión bibliográfica fue analizar los efectos del ayuno intermitente junto con la práctica de actividad física, sobre el rendimiento y la composición corporal de los deportistas. La búsqueda se realizó en las bases de datos Web of Science y Scopus, a partir de los descriptores «intermittent fasting» y «intermittent dietary intake». De los 246 resultados obtenidos inicialmente, 20 cumplieron con los criterios de inclusión y fueron seleccionados para este estudio. Los artículos analizados se centran principalmente en la realización de ayuno intermitente y ejercicio físico, para la mejora del rendimiento y la composición corporal. Tras el análisis, encontramos hallazgos coincidentes con la literatura nacional e internacional respecto a los beneficios de la práctica del ayuno intermitente. En conclusión, el ayuno intermitente junto con la práctica de actividad física, favorece la pérdida de masa grasa y, por consiguiente, del peso corporal, además de favorecer una mejora de los biomarcadores relacionados con la salud. No obstante, toda la literatura científica revisada, sugiere la necesidad de llevar a cabo más estudios para reforzar estas conclusiones.
Situated Agency in Digitally Artifacted Social Interactions
Authors: Ibnelkaïd Samira , Avgustis Iuliia
Published: June 2023

This special issue brings together video-based studies on the local accomplishment of human and non-human agency in digitally artifacted social interactions. It seeks to overcome the dual ontological approach to agency by observing its situated, multimodal, and dynamic enactment by interactants. This gathered body of research explores the notion of situated agency through various lenses. Contributions to this issue can be split into four groups: human-chatbot interactions (smart speakers and service telephone chatbots), human-robot interactions (social robots and robots in educational settings), interactions with digital technologies in specific contexts (autonomous cars and pedestrians, virtual reality and atypical users), and face-to-face human interactions involving the use of digital devices in mundane settings.
100 years of anthropogenic impact causes changes in freshwater functional biodiversity
Authors: Eastwood Niamh , Zhou Jiarui , Derelle Romain , Abdallah Mohamed Abou-Elwafa , Stubbings William A. , Jia Yunlu , Crawford Sarah E. , Davidson Thomas A. , Colbourne John K. , Creer Simon , Bik Holly , Holler Henner , Orsini Luisa
Published: June 2023

Despite efforts from scientists and regulators, biodiversity is declining at an alarming rate. Unless we find transformative solutions to preserve biodiversity, future generations may not be able to enjoy nature’s services.We have developed a conceptual framework that establishes the links between biodiversity dynamics and abiotic change through time and space using artificial intelligence. Here, we apply this framework to a freshwater ecosystem with a known history of human impact and study 100 years of community-level biodiversity, climate change and chemical pollution trends. We apply explainable network models with multimodal learning to community-level functional biodiversity measured with multilocus metabarcoding, to establish correlations with biocides and climate change records. We observed that the freshwater community assemblage and functionality changed over time without returning to its original state, even if the lake partially recovered in recent times. Insecticides and fungicides, combined with extreme temperature events and precipitations, explained up to 90% of the functional biodiversity changes. Community-level biodiversity reliably explained freshwater ecosystem shifts whereas traditional quality indices (e.g. Trophic Diatom Index) and physicochemical parameters proved to be poor metrics for these shifts.Our study advocates the advantage of high throughput systemic approaches on long-term trends over species-focused ecological surveys to identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
Authors: Kandola Tej , Venkatesan Shriram , Zhang Jiahui , Lerbakken Brooklyn , Schulze Alex Von , Blanck Jillian F , Wu Jianzheng , Unruh Jay , Berry Paula , Lange Jeffrey J. , Box Andrew , Cook Malcolm , Sagui Celeste , Halfmann Randal
Published: June 2023

A long-standing goal of amyloid research has been to characterize the structural basis of the rate-determining nucleating event. However, the ephemeral nature of nucleation has made this goal unachievable with existing biochemistry, structural biology, and computational approaches. Here, we addressed that limitation for polyglutamine (polyQ), a polypeptide sequence that causes Huntington’s and other amyloid-associated neurodegenerative diseases when its length exceeds a characteristic threshold. To identify essential features of the polyQ amyloid nucleus, we used a direct intracellular reporter of self-association to quantify nucleation frequencies as a function of concentration, conformational templates, and rational polyQ sequence permutations. We found that nucleation of pathologically expanded polyQ involves segments of three glutamine (Q) residues at every other position. We demonstrate using molecular simulations that this pattern encodes a four-stranded steric zipper with interdigitated Q side chains. Once formed, the zipper poisoned its own growth by engaging naive polypeptides on orthogonal faces, in a fashion characteristic of polymer crystals with intramolecular nuclei. We further show that preemptive oligomerization of polyQ inhibits amyloid nucleation. By uncovering the physical nature of the rate-limiting event for polyQ aggregation in cells, our findings elucidate the molecular etiology of polyQ diseases.
Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
Authors: Bernou Corentin , Mouthon Marc-André , Daynac Mathieu , Demaille Benjamin , Barroca Vilma , Couillard-Despres Sébastien , Dechamps Nathalie , Ménard Véronique , Bellenger Léa , Antoniewski Christophe , Chicheportiche Alexandra , D. Boussin François
Published: June 2023

The lateral wall of the subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular profiling at the single cell level struggles to distinguish these different cell types. Here, we combined transcriptome analyses of FACS-sorted cells and single-cell RNAseq to demonstrate the existence of an abundant, clonogenic and multipotent population of immature neuroblasts (iNB or D cells) at the transition between TAP and migrating NB (mNB). iNB are reversibly engaged in neuronal differentiation. Indeed, they keep molecular features of both undifferentiated progenitors, plasticity and unexpected regenerative properties. Strikingly, they undergo important progressive molecular switches, including changes in the expression of splicing regulators leading to their differentiation in mNB subdividing them into 2 subtypes, D1 and D2. Due to their plastic properties, iNB could represent a new target for regenerative therapy of brain damage.
β-arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Authors: Daly Carole , Guseinov Akim Abdul , Hahn Hyunggu , Tikhonova Irina G. , Thomsen Alex Rojas Bie , Plouffe Bianca
Published: June 2023

The vasopressin type 2 receptor (V
2
R) is an essential GPCR in renal regulation of water homeostasis. Upon stimulation, the V
2
R activates Gα
s
and Gα
q/11
, which is followed by robust recruitment of β-arrestins and receptor internalization into endosomes. Unlike canonical GPCR signaling, the β-arrestin association with the V
2
R does not terminate Gα
s
activation, and thus, Gα
s
-mediated signaling is sustained while the receptor is internalized. Here, we demonstrate that this V
2
R ability to co-interact with G protein/β-arrestin and promote endosomal G protein signaling is not restricted to Gα
s
, but also involves Gα
q/11
. Furthermore, our data implies that β-arrestins potentiate Gα
s
/Gα
q/11
activation at endosomes rather than terminating their signaling. Surprisingly, we found that the V
2
R internalizes and promote endosomal G protein activation independent of β-arrestins to a minor degree. These new observations challenge the current model of endosomal GPCR signaling and suggest that this event can occur in both β-arrestin-dependent and -independent manners.
Collateral damage: has the COVID-19 pandemic more strongly impacted medical research than other scientific areas?
Authors: Farji-Brener Alejandro , Amador-Vargas Sabrina
Published: June 2023

The principle of resource allocation states that diversion of resources to attend a function may compromise others. The COVID-19 pandemic required a rapid response with a justifiable relocation of equipment, funds and human resources. Based on the ecological principle of allocation, we tested whether the relocation of resources to support COVID-19 research was more detrimental to medical research than to research in other scientific areas. We compared the yearly number of published articles from 2015 to 2021 using disease-related keywords and non-medical scientific keywords. Contrary to the expectation, we found an abrupt reduction in the publication rates in all research areas from 2019 to 2020 or 2021, compared to the pre-pandemic period (2015–2019). The allocation effect on medical research may be overshadowed by stronger effects of the pandemic, or it may become evident in the coming years. The drastic reduction in published papers could have negative consequences for scientific advancements, including understanding and curing diseases other than COVID-19 that strongly affect humanity.
Gestão de risco no setor público
Authors: Silva Junior Garcitylzo do Lago , Roberto José Carlos Alves , Da Cunha Edileuza Lobato , De Lima Orlem Pinheiro , De Araújo Paulo César Diniz , Maduro Márcia Ribeiro , De Oliveira Júnior Nilson José
Published: June 2023

Os riscos interferem em todos os níveis das atividades do negócio e, se não forem gerenciados de maneira correta, poderão resultar em perdas financeiras, deterioração da imagem e reputação ou desencadear uma crise. Gerenciar esses riscos denota o uso contínuo de políticas, procedimentos e práticas de gestão para as atividades de comunicação, consultas, estabelecimento do contexto, e na identificação, análise, avaliação, tratamento, monitoramento e análise crítica dos riscos. Este artigo buscou responder ao seguinte questionamento: Qual a importância do gerenciamento de risco para eficácia da administração pública? Tem como objetivo geral analisar a importância do gerenciamento de risco para a eficácia da administração pública e como específicos identificar os principais fatores de riscos utilizados nos projetos da  gestão pública; analisar a eficácia do gerenciamento de risco na administração pública e discutir a importância da eficácia do gerenciamento de risco com os  gestores públicos. Como metodologia o artigo optou quanto a natureza pela quantitativa, quanto aos fins por ser descritiva e quanto aos meios em utilizar a bibliográfica. Dentre os autores utilizados neste trabalho podemos citar Ávila (2013), Souza (2019), Santos (2020). Ao término da pesquisa concluimos que o setor público tanto na esfera municipal, estadual e federal deveria realizar a inclusão mais aprofundada e sistematica do gerenciamento de riscos por meio de uma mudança de cultura no que diz respeito a entrega com eficácia e eficiência de seus serviços a sociedade.
Gestão pública integrada e sustentabilidade organizacional
Authors: Pereira Ilmar Polary-Pereira , Da Costa Gustavo Pereira
Published: June 2023

O estudo objetiva apontar os impactos da Gestão Pública Integrada na Sustentabilidade Organizacional. Investigou “qual o impacto da Gestão Pública Integrada e das tecnologias nas organizações e no desenvolvimento social?”. No método, pesquisas na literatura e de campo em organizações industriais, com amostras aleatória estratificada e por acessibilidade em organizações púbicas. Como contribuições teóricas, pontua avanços para a academia em termos de gestão pública e privada, e das tecnologias que favorecem a sustentabilidade organizacional, visando debates na comunidade acadêmica e de investigação empírica nas organizações. Nas contribuições gerenciais e sociais, apontam que o uso de tecnologias de gestão nas organizações, dentre elas, a Gestão por Sustentabilidade Integrada, fundamentada na Teoria do Empreendedorismo, impacta no desenvolvimento gerencial e social sustentável. Dentre os resultados e conclusões, sugerem que Gestão Pública Integrada, aliada às tecnologias de gestão, impactam na sustentabilidade organizacional, no desenvolvimento sustentável e na sociedade.
Análise dos indicadores financeiros das instituições filantrópicas operadoras de planos de assistência à saúde
Authors: Gomes Wekslei Cordeiro , De Souza Antônio Artur , De Abreu Daniel Pereira Alves , Fonseca Simone Evangelista
Published: June 2023

Entre as operadoras de planos de saúde (OPS), têm-se as operadoras filantrópicas, as quais possuem papel fundamental para auxílio do setor público para a prestação de serviços de saúde. Dado que estudos anteriores apontam uma dificuldade para gestão de OPS, o presente trabalho visa analisar as OPS filantrópicas para verificar sua saúde financeira. Foram calculados 17 indicadores financeiros acompanhados pela ANS das OPS de 2010 a 2018. Além disso, a amostra foi segregada de acordo com seu porte para que os resultados pudessem ser comparados. Entre os principais resultados, destaca-se a dificuldade de gestão financeira, sobretudo das OPS de pequeno e médio porte, devido ao aumento dos custos de serviços somados com dificuldades de gestão de capital de giro. Isso acaba por impulsionar a utilização de passivos de curto prazo para financiar ativos de longo prazo, o que prejudica sua liquidez como também as deixa mais propensas a risco de falência. Considerando que a manutenção deste serviço é de grande importância, especialmente para a população mais carente do país, são necessárias políticas públicas de fomento, bem como bons gestores, para que esse quadro possa ser revertido e para que a viabilidade desse serviço possa ser alcançada.
Isolation and Screening of Agriculturally Important Bacteria (PGPR) from Organic Sources of Nutrient (Panchgavya, Jeevamrit and Farm Yard Manure) for Future Use
Authors: Dhiman Meenakshi , Rana Neerja , Ghabru Arti
Published: June 2023

Agriculture is an essential component to maintain the human health but due to sudden increase in population the demand has increased and to meet the requirement the use of chemical fertilizer has also increase. The continuous use of chemical fertilizer and pesticides degrade the quality and fertility of soil and also reduce the yield of various crops. The organic sources such as panchgavya, jeevamrit and Farm Yard Manure consists load of beneficial microorganisms that promote the plant growth, yield and promote natural resources. The present study was carried out by isolating the bacteria from organic sources (panchgavya, jeevamrit and FYM) because minute amount of bacterial culture is suffient to prepare large one according to need and can be stored for longer time as compare to organic input. The samples of panchgavya, jeevamrit and FYM were collected from different location of Himachal Pradesh. A total of 32 bacterial isolates from panchgavya, 43 from jeevamrit and 59 from FYM were isolated and screened for multiple plant growth promoting traits. Only 4 bacterial isolates from panchgavya, 2 from jeevamrit and 2 from FYM were preferred on the basis of maximum plant growth promoting traits like P-solubilization, Nitrogen fixer, Siderophore production, HCN production, IAA production and Antifungal activity. From the selected bacterial isolates 67.78% were P- solubilizers, 60.37% were Nitrogen fixer, 62.37% were Siderophore producer, 34.29% HCN producer, 45.88% IAA producer and 78.22% show antagonism against Pythium graminicolum and 74.81% show antagonism against Collectotrichum capsici. Hence these bacterial isolates have potential to act as biofertilizer for environment friendly sustainable agriculture systems and alternative to harmful chemicals.
The Development Model of Ecotourism Management in Gunung Botak, the South of Manokwari Regency, West Papua Province, Indonesia
Authors: Inden Jemmy , Kaber Yuanike , Pakage Stepanus , Bawole Roni , Sirami Eliezer V. , Raharjo Syafrudin
Published: June 2023

The South of Manokwari Regency has many kinds of tourism objects with specifications characteristic of natural landscapes i.e., coastal ecotourism (marine ecotourism), and high land ecotourism (i.e., Gunung Botak areas and Arfak Mountains). This article is a review based on the research and the justification of scientific writing with purposed: to review and analyze the potential of Gunung Botak Ecotourism, the suitability and carrying capacity, the performance of regional of tourism social-economic in The South of Manokwari Regency that could be developed as the ecotourism object in national and international’s class and to designed the Development Model of Ecotourism Management in Gunung Botak. The determination of the ecotourism object has done based on the exploration assessment about the object and attractions in a score determination. The assessment of suitability and carrying capacity with scientific justifications i.e.  (1) natural ability to tolerate human disturbance or distress, and (2) standard the authenticity of natural resources. The quality of natural scenery (lanscape) there would be the degree of quality Gunung Botak Ecotourism categories scores >19 (Clas A, High Quality). Ecotourism activity in Gunung Botak consists of recreation, sports tourism in a natural hollow and camping, with wide areas is 5063.5 m2. The projections of potential regional income in entrance fee tariff from foreign tourist is Rp. 35.550.000,-/day and domestic tourism is Rp.1.135.000,-/day. The management strategy of development Gunung Botak ecotourism in South Manokwari Regency could be done with determined the segmentation of ecotourism marketing.
Bioactivity of Hibbertia scandens – an Australian Aboriginal Traditional Medicinal Plant
Authors: Alreemi Roaa M. , Alkatabi Hind A.
Published: June 2023

The First Australian Community is one of the ancient civilizations which has been dependent upon the available surrounding natural resources for their clothing, nutrition and healing of disease. Unfortunately, some of their traditional medicines and / or their practical applications are lost because of poor written documentation. Plants form parts of ancient remedies used by Aboriginal peoples to heal several ailments due to their therapeutic activities. One of these medicinal plants is Hibbertia scandens (Snake Vine), which has been used by Aboriginal Communities as a traditional medicine to treat sores and rashes due to antibacterial and antiseptic properties of this plant.
Nano Nitrogen for Increasingyield of Maize (Zea mays L.)
Authors: Krishna Murali , Chhabra Vandna
Published: June 2023

Nitrogen fertilizers play an important role in the cultivation of crops, excessive and improper usage of fertilizers cause severe issues with respect to human and environment. It is essential to go for alternative sources of nitrogen like nano nitrogen with slow and controlled release of nitrogen.An experiment was conducted at Agriculture Research Farm, Lovely Professional University, Phagwara, during kharif 2022 by using the nano source of nitrogen in maize crop.The experiment was laid out in the randomized block design with eight treatments replicated thrice.Among the different combinations of recommended dose of fertilizers along with nano urea the treatment applied with 100% N+Nano N applied twice at 30 and 60 days after sowing(T6) was thebest treatmentin terms of growth and yield (7.2 t/ha).
Investigating the Influence of Rhizome Size and Treatment on Turmeric Crop Productivity (Curcuma longa L.)
Authors: Barad A. V. , Viradiya Y. A.
Published: June 2023

The experiment was conducted during the Kharif season of 2021-22 at the Department of Seed Technology, Sardarkrushinagar Dantiwada Agricultural University in Sardarkrushingar. It followed a Randomized Complete Block Design (Factorial concept) with three replications, utilizing the GNT 2 variety. The study aimed to investigate the effects of seven treatments and four rhizome sizes on various characteristics of turmeric. The results indicated that both the rhizome size R4 (mother rhizome) and treatment T4 (Chiller treatment at 4°C for 2 hours) significantly influenced all the measured traits. The mother rhizome (R4) exhibited the highest values for germination percentage (80.48%), plant height (64.52 cm), leaf length (36.96 cm), leaf width (13.50 cm), tillers per plant (3.21), mother rhizomes per plant (2.32), primary fingers per plant (7.33), secondary fingers per plant (7.94), rhizome length (14.89 cm), rhizome width (15.54 cm), and rhizome weight (185.25 g). Furthermore, among the different treatments, the chiller treatment (T4) at 4°C for 2 hours yielded significantly higher results for germination percentage (85.98%), plant height (65.35 cm), leaf length (34.51 cm), mother rhizomes per plant (2.38), primary fingers per plant (6.70), secondary fingers per plant (7.95), rhizome length (14.13 cm), rhizome width (15.58 cm), and rhizome weight (187.23 g). The sodium hypochloride treatment (T5) at 4% for 2 hours resulted in the maximum leaf width (12.96 cm) and the number of tillers per plant (3.24). In conclusion, these findings emphasize the potential benefits of pre-sowing rhizome treatment for enhancing turmeric crop cultivation, leading to improved crop performance.