bluuebunny/crossref_metadata_2025 huggingface dataset:
Aquaponics planning to management: Guide book
Authors: Tadesse Abebe
Published: September 2023

Aquaponics is a sustainable and innovative farming method that combines aquaculture (fish farming) and hydroponics (soilless plant cultivation). This system creates a symbiotic relationship between fish and plants, where the fish waste provides nutrients for the plants, and the plants filter and purify the water for the fish. This guidebook provides a comprehensive overview of aquaponics planning and management. It covers the benefits of aquaponics, key components of a system, different types of aquaponics systems, and how to choose the right system for specific needs. The guidebook also delves into system design and construction, including determining system size and scale, setting up the fish tank, designing grow beds, and establishing water circulation. It provides step-by-step instructions for system setup, ensuring proper water quality, and optimizing nutrient cycling. Additionally, the guidebook offers insights into planting and cultivating various crops in aquaponics, including vegetables, herbs, and fruits. It covers essential aspects like seed selection, transplanting, crop care, and pest management. Furthermore, the guidebook provides guidance on monitoring system performance, conducting routine maintenance, and troubleshooting common issues. It addresses challenges related to water quality, nutrient balance, pests, diseases, and equipment maintenance. Lastly, the guidebook highlights the importance of harvesting and utilizing the produce in aquaponics. It discusses proper harvesting techniques, utilizing the harvested produce in culinary endeavors, sharing or selling surplus produce, creating value-added products, and seed saving. By following the guidance presented in this guidebook, individuals and communities can successfully plan, construct, and manage their own aquaponics systems. This resource aims to empower readers with the knowledge and tools to cultivate fresh, sustainable, and nutrient-rich produce through aquaponics.
A Study on Suspension Geometry for Personal Mobility Vehicles (PMVs) with Inward Tilt Mechanism
Authors: Haraguchi Tetsunori , Kaneko Tetsuya
Published: September 2023

Since the concept of a Personal Mobility Vehicle (PMV) that tilts inward while turning is relatively new, there is currently a lack of theoretical considerations regarding the suspension mechanism. Therefore, this study aims to explore the theoretical relationship between suspension geometry and the pitching posture during turning in a PMV with two front wheels and one rear wheel that tilts inward during turns. Our findings suggest that a combination of a front telescopic suspension and a rear full trailing arm (swing arm) suspension is suitable for minimizing both the squatting pitching of the vehicle body during turns and the disturbances caused by changes in tread and tire camber angles during wheel strokes in the upright driving position from a static force balance perspective. From a dynamic perspective, there is no significant concern about pitching occurring even in cases where there may be a delay in active tilt angle tracking (PID) control when using the combination of front telescopic suspension and rear full trailing arm suspension. However, it is essential to note that a large sprung roll moment of inertia can still induce the squatting pitching.
Hodgkin Lenfoma
Authors: Erkut Nergiz
Published: September 2023

Hodgkin lenfoma (HL), lenfatik sistemin nadir görülen malign bir neoplazisidir. Tüm lenfomaların yaklaşık %10’unu oluşturmaktadır. Sıklıkla gençlerde izlenmekle birlikte, daha az oranda yaşlılarda da gözlenmektedir. HL, germinal merkez B lenfositlerden kaynaklanan ve tümöral mikroçevrede belirgin inflamatuvar hücre artışı ile karakterize bir malignensidir. Klinik ve patolojik özellikleri farklı olan klasik HL ve nodüler lenfosit-predominant HL (NLPHL) olmak üzere iki tipi mevcuttur. Klasik HL vakaların %90-%95’ini, NLPHL ise %5-10’unu oluşturmaktadır. Kemoterapi ve/veya radyoterapi ile hastaların yaklaşık %80’inde kür sağlanmaktadır. Bu derlemede HL’nin epidemiyoloji, etiyoloji, patobiyoloji, klinik, tanı ve tedavisi üzerinde durulacaktır.
Comparative Study on the Efficiency of Using Pulsed and Direct Current Electrochemotherapy in Treating Ehrlich Tumor
Authors:   MedicalBiophysics Department, Medical Research Institute, Alexandria University, Egypt, Elblbesy Mohammed A. , Shawki Mamdouh M. , Shalaby Thanaa E. , Qotb Metwali A. , Youssef Youssef S.
Published: September 2023

The Electrochemotherapy (ECT) is an effective treatment of cutaneous and subcutaneous solid tumors. Electric field is applied to tumor nodules to enhance the delivery/distribution of a non-permeable or poorly permeable chemotherapeutic agent into the tumor cells thereby increasing local concentration of anticancer drugs. The aim of this study was to evaluate the effectiveness of using two types of electric fields in ECT, pulsed sine waves and direct current (DC) application in addition to intra-tumoral injection of bleomycin (BLM), a cytotoxic drug for treating Ehrlich tumor. The electric fields were delivered through six stainless steel needle electrodes inserted into the tumor. Tumor volume, tumor mass, percentage of fragmented DNA in the tumor tissue, relative spleen mass/total body mass, mortality rate, histological and ultrastructural examinations were investigated in each group. There were 40% complete response (CR) and 60% partial response (PR) in the group treated with DC as the electric field source of ECT, while 0% (CR) and only 25% (PR) were found in the group treated with pulsed sine wave ECT. We concluded that the utilization of low dose DC for ECT gives better results than the low voltage pulsed sine waves in treating Ehrlich tumor which may be due to the dual effects of electrochemical reactions evoked by DC application and the anti-cancer activity ofBLM.
Reconstruction and Visualization of Human Gastrointestinal Tract
Authors:   School of medical instrument and food engineering, University of Shanghai for Science and Technology, Shanghai, China, Yan Rong-guo , Xu Changqing ,   Shidong hospital of Shanghai, Shanghai, China, Guo Xu-dong ,   School of medical instrument and food engineering, University of Shanghai for Science and Technology, Shanghai, China
Published: September 2023

Background: Converting the two-dimensional (2D) cross-sectional photographs into an intuitive three-dimensional (3D) model is a basic task for medical imaging data for auxiliary disease-linked diagnosis purpose. Methods: Reconstruction and visualization process of gastrointestinal cross-sectional photographs includes image preparation, image registration, image segmentation, 3D surface-rendering reconstruction, and implementation of 3D digital visualization. Results: Using the visualization toolkit (VTK), we implemented 3D digital reconstruction and visualization of gastrointestinal tract, whose visualized model can be zoomed, paned, and rotated, including the stomach, the small intestine, and the large intestine.
Validated Densitometric TLC-Method for the Simultaneous Analysis of (R)- and (S)-Citalopram and its Related Substances using Macrocyclic Antibiotic as a Chiral Selector: Application to the Determination of Enantiomeric Purity of Escitalopram
Authors:   National Organization for Drug Control and Research (NODCAR), Egypt, Soliman Suzan Mahmoud
Published: September 2023

A novel economic procedure for the simultaneous stereospecific separation and analysis of (R)- and (S)-citalopram and its related substances or impurities has been developed and validated. Chromatography was performed on silica gel 60 F254 plates with acetonitrile: methanol: water (15:2.5:2.5: v/v/v) as a mobile phase containing 1.5 mM norvancomycin or 2.5 mM vancomycin as a selector at ambient temperature. (R)- and (S)-citalopram enantiomers in presence of its related substances; citalopram citadiol and citalopram N-oxide were well separated with significant Rf values of 0.33 ± 0.02, 0.85 ± 0.02, 0.45 ± 0.02 and 0.22 ± 0.02, respectively. The spots were detected with either iodine vapor, or by use of a UV lamp followed by densitometric measurement at 239 nm. All variables affecting the resolution, such as concentration of chiral selectors, mobile phase system at different temperatures and pH-values were investigated and the conditions were optimized. Calibration plots for analysis of (R)- and (S)-enantiomers were linear in the range of 0.2-16.8 µg/10 µl (R≥0.9994, n-6) with acceptable precision (%RSD<2.0) and accuracy (99.70 ± 0.85% and 99.51 ± 0.61% for (S)-citalopram and escitalopram, respectively). The limit of detection and quantification were 0.08 µg/10 µl and 0.25 µg/10 µl, respectively, for (R)- and (S)-citalopram. The proposed method is simple, selective, and robust and can be applied for quantitative determination of enantiomeric purity of (R)- and (S)-citalopram (escitalopram) as well as the related impurities in drug substances and pharmaceutical preparations. The method can be useful to investigate adulteration of pure isomer with the cheep racemic form.
The Predominant Proteins that React to the MC-20 Estrogen Receptor Alpha Antibody Differ in Molecular Weight between the Mammary Gland and Uterus in the Mouse and Rat
Authors:   Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA, Liao D. Joshua , Sun Yuan ,   Hormel Institute, University of Minnesota, Austin, MN 55912, USA, Bollig-Fischer Aliccia , Thakur Archana , Wu Jiusheng ,   Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Published: September 2023

There are many estrogen receptor α(ERα) antibodies available but few of them target a rodent ERα. Using the MC-20 antibody raised against the C-terminus of mouse ERα, we show in this communication that in the mammary gland of female mice and rats, the wild type (wt) ERα was detected on immunoblots as a dominant protein only during lactation, and the protein was lactating specific as it migrated slightly faster than the 67-kD wt ERα in the uterus, likely due to a different phosphorylation status. In contrast, in the nulliparous, pregnant, involuting and involuted mammary glands, the dominant protein recognized by MC-20 was about 61-kD, which is dubbed herein as "MC-20 reactive protein" or MC20RP in abbreviation as its identity is unknown. Our results showed that it was not derived from proteolysis or de-phosphorylation of the 67-kD ERα and was unlikely to be translated from an ERα mRNA variant. Ovariectomy decreased the lactating specific wt ERα but increased the 61-kD MC20RP in the mammary tumors from MMTV-c-myc transgenic mice but these two proteins in the uterus were unaffected. The 61-kD MC20RP was decreased in the mammary tumors, compared with proliferating mammary glands, in estrogen-treated ACI rats. These results suggest that while the lactating specific wt ERα alone or together with the MC20RP may sustain lactation, the MC20RP may support proliferation of the mammary gland and some mammary tumors.
Histological and Demographic Characteristics of the Distribution of Brain and Central Nervous System Tumors' Sizes: Results from SEER Registries Using Statistical Methods
Authors:   Department of Mathematics and Statistics, University of South Florida, USA, Pokhrel Keshav P. , Vovoras Dimitrios , Tsokos Chris P.
Published: September 2023

The examination of brain tumor growth and its variability among cancer patients is an important aspect of epidemiologic and medical data. Several studies for tumors of brain interpreted descriptive data, in this study we perform inference in the extent possible, suggesting possible explanations for the differentiation in the survival rates apparent in the epidemiologic data. Population based information from nine registries in the USA are classified with respect to age, gender, race and tumor histology to study tumor size variation. The Weibull and Dagum distributions are fitted to the highly skewed tumor sizes distributions, the parametric analysis of the tumor sizes showed significant differentiation between sexes, increased skewness for both the male and female populations, as well as decreased kurtosis for the black female population. The effect of population characteristics on the distribution of tumor sizes is estimated by quantile regression model and then compared with the ordinary least squares results. The higher quantiles of the distribution of tumor sizes for whites are significantly higher than those of other races. Our model predicted that the effect of age in the lower quantiles of the tumor sizes distribution is negative given the variables race and sex. We apply probability and regression models to explore the effects of demographic and histology types and observe significant racial and gender differences in the form of the distributions. Efforts are made to link tumor size data with available survival rates in relation to other prognostic variables.
Biosimilars and Generics: A New Class Needed for Hormonal and Herbal Preparations
Authors: Sanjay Kalra  , Megha Sharma  , Nitin Kapoor
Published: September 2023

Strict regulations are in place for the manufacture and approval of pharmaceutical products. Specific drugs such as biological products are governed by specific rules, which take cognizance of the extra diligence required for their production. This communication describes two classes of drugs: hormones and herbal products, which should be subject to stringent regulations. It explains the rationale behind this, and calls for added vigilance in regulatory oversight.
GOOD CORPORATE GOVERNANCE AND FINANCIAL PERFORMANCE: A CASE OF INDONESIAN CONSUMER GOODS INDUSTRY
Authors: Ameraldo Fedi
Published: September 2023

The purpose of this study is to determine the effect of the board of directors, independent board of commissioners and audit committee on the financial performance of manufacturing companies in the consumer goods industry sector listed on the Indonesia Stock Exchange in 2021. This study uses a quantitative approach with a population of 51 companies. The sample was taken using purposive sampling technique and obtained a sample of 44 companies. The data used in this study are secondary data. The analysis technique in this study uses multiple linear regression. The results of this study indicate that the independent board of commissioners has an effect on financial performance while the board of directors and audit committee have no effect on financial performance.
Antropología Arquetípica y Simbólica Latinoamericana: Transculturación, Aculturación Interculturación, Mirada Científico Administrativo Empalabrada de Miguel Barnet
Authors: Gómez Romero Danny Francis
Published: September 2023

El presente ensayo abierto al dialogo transcomplejo,   su propósito objeto de estudio   establecerá las bases filosóficas, ontológicas, sociales del paradigma hermenéutico simbólico  latinoamericano  sirviendo de soporte para el establecimiento del conocimiento  latinoamericano, basado en andamiajes,  cortes considerados arquetípicos  la  presente reflexión hermenéutico simbólico  que dan cuenta de cómo ha sido el proceso de construcción  epistemológico científico administrativo empalabrada  en frases romanas "iuris tantum",   presunción absoluta. Se utilizó   método hermenéutico etnohistórico arquetípico, como categoría de análisis: mentalidad, propuesto por C. G. Jung para la interpretación de los datos, fuentes, textos, revistas, manuscritos,  otros documentos oficiales  sirvieron de soporte para establecer fundamentos e importancias.  Se concluye en sintonía con el autor Jacksic, en el contexto discursivo antropológico  latinoamericano, en particular el venezolano se retrató a Miguel Barnet, junto a Monsonyi y Madden concebido como un arquitecto de la independencia hispanoamericana, logrando con su pluma más logros que los guerreros con las armas.
Enseñanza de la metodología de la investigación en la educación universitaria.
Authors: Marcano de Blanco Eladia
Published: September 2023

El propósito de este producto intelectual de investigación es presentar el Estado del Arte sobre la enseñanza de la metodología de la investigación en la educación universitaria, por cuanto este conocimiento que cosifica los hechos a investigar, pareciera que se convierte, gracias a esta manera de ver el método, en uno de los obstáculos epistemológicos más comunes y preocupantes en el fracaso del estudiante universitario, en su construcción de sus productos de investigación. Para ello transitamos en un ejercicio  heurístico e interpretativo-crítico en diversas fuentes documentales. Primeramente  se toman algunas fuentes importantes, a saber, las estadísticas de la  Unesco,  en cuanto a la cantidad de investigadores por región del mundo, se consultaron tesis doctorales desde el año 2016 hasta los actuales momentos en las distintas páginas web de las universidades nacionales donde se dicta el programa de Doctorado en Ciencias de la Educación, tales como: La UNESR, ULA, UPEL, UCV, UCAB, USM, URBE, donde no se encontraron antecedentes al respecto, se consultaron universidades internacionales. Se consultaron 25 libros de metodología de la investigación, con el objeto de obtener el concepto de metodología, dando como resultados únicamente tres libros, así como las semejanzas y diferencias de la forma de desarrollar el problema y el proceso de investigación, también se consultaron libros relacionados con la formación investigativa y la Ciencias, entre la búsqueda se seleccionaron 20 artículos de revistas científicas, obteniendo información de la enseñanza de la metodología de la investigación, los obstáculos para investigar. Se puede concluir, que la enseñanza de la metodología debe ser complementada con los distintos enfoques, métodos y paradigmas.
The Influence Of Science Dichotomy On Islamic Religious Education Curriculum
Authors: Wahyu Aji  , Ziyah  , Mahwiyah
Published: September 2023

Islamic religious education is defined as a conscious effort to prepare students to believe, understand, live, and practice the Islamic religion through activities, guidance, teaching, and training by taking into account the demands to respect other religions and relations between religious communities in society in order to realize national unity. Integrated Islamic Education is an alternative to overcome the occurrence of educational dichotomy. But this Integrated Islamic education can be carried out with the condition that the two existing education systems in Muslim countries can be merged into one system, as long as the philosophical basis remains Islamic. The style of integrated Islamic education is the integration or combination of various existing education systems, without the dichotomy of religious knowledge and general science. So that it can give birth to an education system that is inspired by Islam. Islam has never considered the dichotomy of science and religion. Science and religion are an integral totality that cannot be separated from one another.
Quality Improvement Of Islamic Education
Authors: Ali Akbar
Published: September 2023

Education has a very big role and at the same time is a very important resource. Especially for developing countries. Because education is a very important requirement for human life. Education will help shape personality in the future as well as having the function of developing capabilities and improving the quality of life and human dignity in Indonesia in order to realize national goals. Efforts made by teachers in overcoming strategic obstacles in improving the quality of Islamic religious education learning include improving the quality of student learning to study Islamic religious education subjects, procuring guidebooks or literature on Islamic religious education subjects, mastering learning methodologies for teachers on subjects Islamic education
Application of the Assignment Method in Enhancing Student Learning Enthusiasm in the Subject of Jurisprudence
Authors: Sri Sulastri
Published: September 2023

The objectives to be obtained from this research are: Want to know the effect of applying the recitation method in increasing student learning enthusiasm in fiqh subjects at mts Darul Falah Bongas Indramayu, want to know the obstacles faced in applying the recitation method (assignment assignments) in subject areas Jurisprudence study at Mts Darul Falah Bongas Indramayu, wanted to find out how effective the application of the recitation method (assignment assignments) was in increasing student enthusiasm for the subject of Fiqh study at MTs Darul Falah Bongas Indramayu. This type of research is field research that uses a descriptive qualitative method approach which uses the results obtained using the data collection method using the interview and documentation methods obtained when the researcher conducts research in class, and to obtain the results of the data needed the researcher conducts interviews and takes documentation. from students and teachers there. There is also a conclusion from this research that this method is very interesting where teachers and students not only do assignments in class but can be done anywhere, and children are quite enthusiastic about this method in their class when it is implemented.
Acceso abierto y revistas científicas en la UNA
Authors: Achinelli Báez Marcela Fernanda , Villagra Ferreira Mirtha Graciela , Duarte Caballero Alicia
Published: September 2023

La ciencia abierta plantea el acceso abierto de los diferentes elementos que componen la ciencia, para que esto sea posible, es necesario una transformación en la manera tradicional de hacer ciencia. Si bien los conceptos de ciencia abierta estuvieron tácitamente presentes a lo largo de la evolución, con la aparición de internet se considera como un producto de ello, debido a la capacidad de generar la desintermediación en los procesos de acceso y divulgación de la información. El objetivo de este trabajo fue describir la situación de las revistas científicas de la Universidad Nacional de Asunción a partir de los principales indicadores del acceso abierto disponibles. Para ello se desarrolló una investigación documental-bibliográfica con enfoque cuantitativo, a partir de los datos los resultados mostraron que, si bien existen 25 revistas dentro de la Universidad Nacional de Asunción, solo 18 de ellas están en el portal de revistas científicas, siendo todas arbitradas e indizadas. El manejo de redes sociales es incipiente, no obstante, denota una mayor cantidad de citaciones en artículos provenientes del área de ciencias de la salud. Paraguay está transitando hacia la ciencia abierta, y para avanzar en los diferentes desafíos es necesario que las acciones puedan ser acordadas entre todas las partes que las integran: la academia, los centros e institutos de investigación, así como los órganos rectores del área científica.
Os semicondutores na América Latina: a fábrica de Chips CEITEC no Brasil
Authors: Villaverde Adão , Amaral Livio
Published: September 2023

Estão em curso mudanças e transformações não apenas nos ativos tangíveis, mas sobretudo na forma como os indivíduos trabalham, vivem e se relacionam em sociedade. Neste contexto é que temos que compreender a importância da microeletrônica e a produção de semicondutores. Este trabalho analisa políticas, instrumentos, planejamento, governança, gestão e resultados da fábrica de chips CEITEC, Centro de Excelência em Tecnologia Eletrônica Avançada, localizada em Porto Alegre, RS, Brasil, única de solução completa na América Latina. Resultado de fundamentais políticas públicas, associados à academia e ao setor empresarial, estudo investiga o passo-a-passo do domínio e capacidade de pesquisar, desenvolver, prototipar, fabricar e comercializar chips, propondo sugestões e ajustes aos seus impasses. E além da importância na superação do déficit tecnológico do país e da região no campo dos semicondutores, onde seu conhecimento, saber e expertise no tema, são os principais ativos intangíveis para transformar a inovação tecnológica em valor às organizações e à sociedade.
Educación superior en la región: heterogeneidades, desafíos y transformaciones
Authors: Giudice Jacqueline , González Inés
Published: September 2023

El artículo ofrece un panorama actualizado de la Educación Superior latinoamericana, con foco en el MERCOSUR, desarrollando procesos influyentes en la expansión de la matrícula. En ese sentido, se analiza la evolución e impacto de los 14 años de escolaridad obligatoria en la región; el notable incremento de la participación femenina en todos los niveles educativos y el grado de compromiso en el financiamiento educativo de los países parte. Se focalizan experiencias innovadoras implementadas para lograr mayores tasas de cobertura en regiones y sectores de la población más desfavorecidos, y que permitieron la aparición en Educación Superior de sujetos antes poco representados. También se ofrecen datos de la incidencia de la educación privada, especialmente en Argentina. Se destacan grandes avances aunque también dificultades para que sectores vulnerables asistan a una educación obligatoria de calidad y accedan a la Educación Superior. Gracias a datos actualizados de las tasas de cobertura y permanencia en la Educación Superior en el MERCOSUR, se focaliza en el ingreso de sectores más desfavorecidos de la población.  Se ofrece entonces un panorama heterogéneo en el que se destacan análisis que apuntan a las particularidades de los sujetos que hoy constituyen los estudiantes de la Educación Superior. El trabajo concluye con los desafíos pendientes y algunas propuestas en pos de cubrir la tasa de escolarización obligatoria, acortar la brecha según el origen urbano-rural y entre  los alumnos de quintiles más desfavorecidos con respecto a los de mejores recursos, para incrementar su representación en ese sector educativo
Reseña. Tendencias recientes en las políticas científicas de Ciencia Abierta y Acceso Abierto en Iberoamérica
Authors: González Ana Luna
Published: September 2023

La publicación se estructura en cinco apartados. El primero introduce la fundamentación del estudio, y en los capítulos siguientes se presentan los resultados de la investigación. En el segundo apartado, se encuentran los antecedentes internacionales y regionales del movimiento de acceso abierto y los avances en materia de datos abiertos de investigación y ciencia abierta. El tercer apartado sistematiza los casos de los países de Argentina, Brasil, Colombia, Costa Rica, Cuba, Chile, España, México y Perú sobre los avances y los proyectos de acceso abierto, datos abiertos y/o ciencia abierta -según corresponda-. El cuarto capítulo aborda la discusión internacional y regional en materia de evaluación de ciencia y difunde la propuesta de Declaración de Principios del Foro Latinoamericano sobre Evaluación Científica (FOLEC), a fin de transformar los sistemas de evaluación vigentes y alinearlos con los principios y valores de la ciencia abierta. Por último, se despliega un apartado de consideraciones finales en la que se presentan las conclusiones y comparten experiencias valiosas de ciencia abierta y horizontes de políticas en la temática.
Debate sobre ensino, pesquisa e extensão na América Latina
Authors: Da Penha dos Santos Aparecida
Published: September 2023

Dos dias 25 a 27 de Abril de 2023, a Unespar – Universidade Estadual do Paraná– Brasil, realizou o I Congresso Latino-Americano de Ensino, Pesquisa e Extensão (CONLAPE), juntamente com o V Seminário dos Cursos de Ciências Sociais Aplicadas (SECISA). O CONLAPE/SECISA teve como objetivo gerar e divulgar conhecimento, além de oferecer espaço para apresentação de resultados de ações e projetos de ensino, pesquisa e extensão, desenvolvidos no Brasil e em outros países, nas mais variadas áreas do conhecimento. O evento ocorreu na modalidade virtual e sua estrutura foi composta por palestras, mesas-redondas e simpósios temáticos com apresentações de comunicações orais. A abrangência do evento foi além do nível regional, sendo também nacional e global, com ênfase especial para a América Latina.
Expertise of Digital Reality as a Factor of Achieving Society Stability Under Stochastic Conditions (Uncertainty, Instability, Bifurcation)
Authors: Voronkova Valentyna , Oleksenko Roman , Nikitenko Vìtalina
Published: September 2023

Since we all live in a complex, interconnected, and interdependent world, in which the volumes of exponential information growth are increasing; since many leaders realize they are operating under conditions of stochasticity and uncertainty, the relevance of the analyzed problem remains extremely significant. The purpose of the article is to conceptualize the study of digital reality in matters of stochastic ambiguity based on system methodology and computer modeling. This conceptual and categorical apparatus aims to expose digital reality as a social phenomenon and a dynamic process. The principal approach to the research problem is a synergetic methodology that includes methods of consistency, structuredness, reasoning, and makes it credible to unveil the essence of the analysis of digital reality as a factor in achieving societal stability in circumstances of stochasticity, which is an integral process. The article demonstrates that through the ability to predict, mistakes can be avoided, success can be achieved, and the prosperity of organizations can be multiplied. The article explains that the synergetic methodology, as a methodology of complexity, meets the conditions of globalization 4.0, Industry 4.0, technological progress 4.0, digital society, Enlightenment 2.0, and Agile management. It is for these complex requirements that a synergistic complexity methodology can be applied. The materials presented in the article hold practical value for experts, scientists, and leaders. Implementation of this expertise will benefit society, the state, international partners, and future generations by promoting sustainable growth. The practical significance of the article lies in solving the problems of acquiring a conceptual framework for analyzing digital reality as a factor in achieving the efficiency and sustainability of society in circumstances of stochasticity. This approach enables the formulation of national, regional, local, and other indicators of sustainability and contributes to overcoming crises. All indicators mentioned can be manifested in absolute and relative dimensions, including indicators in the social sphere, such as health status, quality of life, social activity, demographics, and others.
Rural Farmers’ Use of Indigenous Crop Management Practices for Climate Variability Adaptation in Imo State, Nigeria
Authors:   Department of Agricultural Extension, School of Agriculture and Agricultural Technology, Federal University of Technology, Owerri, Imo State, Nigeria, CC Godson-Ibeji , GO Aminu , JU Chikaire
Published: September 2023

The study analyzed indigenous crop management practices employed by farmers to ensure adaptation in the face of climate variability in Imo State, Nigeria. A total of 360 farmers were randomly selected from the three agricultural zones of the State. Interview schedule was used to elicit information from the respondents. Percentage, mean and Standard deviation were used to describe data collected. Results showed that the farmers were fully aware of climate variability as indicated by a high percentage score of the various prediction signs; erratic rainfall pattern (86.1%), heavy flooding (94.4%), long rainfall (88.8%) among others. Climate variability affects crop production in the following ways ; crop infestation by pests and diseases (M=3.26), leads to death of farmers (M-3.01), heavy presence of armyworms (M=2.76) among others effects. The farmers used the following indigenous crop management practices use of indigenous grains (94.4%), crop rotation (91.6%), multiple cropping (93.1%) among others. The following are benefits of indigenous crop management practices- practices are cheap and cost free (M=3.32), not harmful to human health (M=3.95), practices have no side effects (M=3.27), readily available domestically (M=3.75), and practices have no expiry date. The above practices are safe and have proved successful for centuries and we recommend that they should be integrated into the modern practices of agriculture.
Professor Dr. Orsos Ferenc - Legally Innocent
Authors:   Health Human International Environment Foundation, Budapest, Hungary, Vincze Janos , Vincze-Tiszay Gabriella ,   Health Human International Environment Foundation, Budapest, Hungary
Published: September 2023

Today it is known that the mass murdering known as the Katyn massacre, was carried out on orders of the Political Bureau of the Central Committee of the Bolshevik Soviet Communist Party, a decision that was made on 5th March 1940. In 1943 the Germans have published an extensive statement that among other things established that the killings have been carried out with 7.65 mm calibre cartridges, produced by Germany. The works of the international committee were carried out by the following scientists: professor Orsos (Hungary), Speelers (Belgium), professor Markov (Bulgaria), Dr. Tamsen (Denmark), professor Saxen (Finland), professor Miloslavic (Croatia), professor Palmieri (Italy), professor Hajek (Czechoslovakia), professor Naville (Switzerland), professor Subik (Slovakia) and as observer Dr. Costedoat (France). The unanimous conclusion of the experts was that the corpses have been buried for approximately three years. Professor Orsos had personally examined 150 corpses. In 1945 the Hungarian Academy of Sciences excluded him, then in 1946 the People’s Tribunal declared him a criminal of war. In November 2012 - after 66 years - the Tribunal of Budapest abolished the proceedings started in 1946 by the Pazmany Peter University. The Court left 8 (eight) days for appeals. Conclusion: Professor Dr. Orsos Ferenc is not a war criminal and there are no operative legal proceedings concerning his person.
Hamstring Injury Rehabilitation in the Female Athlete. A Clinical Case
Authors:   Family Medicine, No Primary Affiliation, Antwerp, Belgium, T Lamens , J Kersschot
Published: September 2023

Hamstring injury is a common sports injury in the female athlete. Both rehabilitation and preventive measures are crucial but not standardized yet. In this article we present a female athlete with a fresh hamstring injury which was treated with both physiotherapeutic treatment as well as with regional sugar water injections into the muscular lesion. The goal of this paper is to share this experience with other physical therapists and sports doctors. This case is also an invitation to the medical community to design randomized trials to confirm our clinical experience with this dual management.
Den danske langsigtede vækstproces
Authors: Dalgaard Carl-Johan
Published: September 2023

Over de sidste 100 år er den danske levestandard blevet forøget markant, overvejende som konsekvens af en evne til at tilegne sig ideer udefra. Det har ikke alene gjort Danmark absolut rigere, men også relativt til de fl este andre lande. Siden 1990’erne er udviklingen imidlertid »slået bak«. Artiklen diskuterer mulige årsager hertil samt potentielle politikanbefalinger.
Det specialiserede socialområde på modificerede markedsvilkår
Authors: Madsen Mogens Ove
Published: September 2023

I 2007 blev det specialiserede socialområde overdraget til kommunerne, hvor køb og salg af tilbud skulle følge en markedslignende model. Dette har undervejs været udsat for meget kritik og evalueringen af socialreformen har derfor været imødeset med stor spænding.
Markederne, økonomerne og moralen
Authors: Kærgård Niels
Published: September 2023

I artiklen diskuteres styringen af samfundet, og det understreges, at moral, etik, religion og traditioner har en vigtig plads i regulering af borgernes adfærd, og at denne funktion langtfra altid kan erstattes af markedsstyring og økonomiske incitamenter.
Handel med kropsdele – Kommercialiseringens etiske grænse?
Authors: Ploug Thomas , Halsnæs Kirsten
Published: September 2023

Handel med kropsdele kan ses som løsningen på en række problemer for køber og sælger og som en udfoldelse af ejendomsretten over kroppen. Artiklen problematiserer kommercialiseringen af kroppen med afsæt i overvejelser om værdighed og udnyttelse og om markeders forudsætninger og effekter.
Fattigdom blandt indvandrere og deres børn
Authors: Pedersen Peder J.
Published: September 2023

Artiklen giver en kort oversigt over udviklingen i relativ fattigdom i de senere år med fokus på børn af indvandrere fra ikke-vestlige lande. Fattigdomsandelen blandt indfødte børn og situationen i andre EU lande og i de nordiske lande inddrages som sammenligningsgrundlag.
Økonomisk styring: Kvantitet og kvalitet
Authors: Møller Pedersen Kjeld
Published: September 2023

Produktivitetskommissionens tre grundregler for økonomisk styring i den offentlige sektor diskuteres kritisk med vægt på DRG og den kommunale medfinansiering. To alternativer til DRG-systemet diskuteres: Et forsøg i Region Midtjylland og arbejdet med såkaldt værdibaseret afregning, hvor der tages hensyn til kvalitet.
Bureaukrati og produktivitet – en diskussion af Produktivitetskommissionens analyser og anbefalinger
Authors: Felsager Jakobsen Mads Leth , Mortensen Peter Bjerre
Published: September 2023

Produktivitetskommissionens analyse af afbureaukratisering i den offentlige sektor er baseret på en problematisk opgørelse af regeludviklingen, og dens anbefalinger tager ikke hensyn til de politiske aspekter af
Ulighed i velstand og velfærd – hele landet, regioner og ledighed
Authors: Bonke Jens
Published: September 2023

Ulighed i fordelingen af indkomster – velstand – og i tilfredsheden med livet i almindelighed – velfærd – diskuteres tillige med velfærdsforskellen mellem regioner, og mellem ledige og beskæftigede baseret på oplysninger fra Danmarks Statistik.
Uligheden, velfærdsstaten og globaliseringen
Authors: Kærgård Niels
Published: September 2023

De nordiske velfærdsstater har været en succes; stor lighed, rige lande og lykkelige folk. Men der er stadig forskel på rig og fattig i Danmark, og der er ingen sikkerhed for, at modellen kan overleve. En lang række tendenser trækker i retning af øget ulighed.
Investeringsbeskyttelse i en kommende frihandelsaftale mellem EU og USA
Authors: Mouyal Lone Wandahl
Published: September 2023

Det traktatbaserede regime til beskyttelse af udenlandsk investering har i de seneste år været genstand for kritik, der dækker over en grundlæggende juridisk problemstilling her omtalt som et stabilitets-fleksibilitets dilemma. Kritikken aktualiseres i forhandlingerne af en større handels- og investeringsaftale mellem EU og USA, the Transatlantic Trade and Investment Partnership (TTIP).
Nobelprismodtagere i makroøkonomi
Authors: Fink Nanna , Sandemann Rasmussen Bo
Published: September 2023

Denne artikel ser nærmere på hvilke makroøkonomer, der er tildelt Nobelprisen i økonomi. Giver en oversigt over hvilke fagområder prismodtagerne har repræsenteret, og hvilken indflydelse de har haft for eftertiden på de økonomiske teorier.
”Var det de rigtige, der fik prisen?”
Authors: Fink Nanna , Leth Haugaard Jens
Published: September 2023

Set fra dette skrivebord er der ingen grund til at føle mit forskningsområde overset. Feltet, der bredt kan betegnes som matematiskøkonomi, mikroøkonomi og spilteori, er velrepræsenteret på listen over Nobelprismodtagere i økonomi.
Nobelprisen i økonomi – til ikke-økonomer
Authors: Fink Nanna , Dreyer Lassen David
Published: September 2023

´Det første felt i kommentarsporet på en hvilken som helst artikel om den årlige Nobelpris i økonomi er ”Det er ikke en rigtig Nobelpris”. Alfred Nobel havde ikke samfundsvidenskaberne med i sine testamenterede tanker, hvilket ikke er så underligt, da samfundsvidenskaberne selv kun var ved at etablere sig som særlige og værdige forskningsfelter ved Nobels død. Det betyder selvfølgelig ikke en pind. Videnskabssociologer argumenterer undertiden for, at akademiske discipliner primært skal forstås som incitamentsstrukturer, og enhver incitamentsstruktur skal have en eller flere priser, som nyder generel anerkendelse. Hvad prisen hedder, er mindre vigtigt.
Dansk pelsdyravl i fortid, nutid og fremtid
Authors: Fink Nanna , Hansen Henning Otto
Published: September 2023

Den danske pelssektor befinder sig i en ofte turbulent verden - økonomisk og markedsmæssigt. Der har været en kraftig vækst og strukturudvikling med udgangspunkt i en stærk international konkurrenceevne. Fremtiden kan gå i meget forskellige retninger.
Debatindlæg: En fælles fremtid for dansk landbrug
Authors: Fink Nanna , Hougaard Nielsen Rasmus
Published: September 2023

Dansk landbrug befinder sig i en historisk unik situation; aldrig har gælden været så høj og jordejerskabet så koncentreret. Denne situation har gjort sektorens økonomiske problemer til et offentligt anliggende, som kræver offentlig indblanding.
Portrait des expériences de violences sexuelles intrafamiliales et extrafamiliales dévoilées par les femmes fréquentant des centres d’aide au Québec
Authors: Bergeron Manon , Lavoie Mongrain Catherine , Hébert Martine , Julien Marily
Published: September 2023

Malgré la forte prévalence de la violence sexuelle au Canada, les connaissances sur les caractéristiques de celle-ci demeurent limitées. Sur la base des données recueillies auprès de 1 824 femmes et adolescentes ayant fait une demande d’aide dans des Centres d’aide et de lutte contre les agressions à caractère sexuel du Québec (CALACS), cet article vise à fournir un portrait des expériences de victimisation sexuelle de ces femmes, de la recherche d’un soutien psychosocial, puis à comparer certaines caractéristiques des situations de violences sexuelles intrafamiliales et extrafamiliales. Les résultats révèlent un taux élevé de revictimisation sexuelle : près de 40 % des répondantes ont rapporté plus de deux situations de violence sexuelle au cours de leur vie. Les situations de violences sexuelles intrafamiliales subies avant l’âge de 18 ans perdurent sur une plus longue période et les personnes victimes les dévoilent plus tardivement que celles rapportant des situations de violences sexuelles extrafamiliales.
Expérience et vécu des parents d’enfants trans et de la diversité de genre vivant en région
Authors: Pullen Sansfaçon Annie , Dionne Natasha , Planchat Tommly , Dyer Jennifer , Picket Sarah , Temple-Newhook Julie , Manning Kimberley , James Julie , Davis Jennifer
Published: September 2023

De plus en plus de recherches démontrent l’importance du soutien parental comme facteur de protection face aux risques de santé mentale pour les jeunes trans et de la diversité de genre (TDG). Ces études sont primordiales pour l’accompagnement et le bien-être de ces jeunes. Toutefois, la perspective des parents vivant hors des grandes métropoles reste peu connue et leur vécu demeure mal compris. Cette recherche, la première sur le sujet, explore ainsi les expériences, les défis et les points plus positifs rencontrés en tant que parents de jeunes TDG vivant en région. Nous avons interviewé 9 parents vivant hors d’un grand centre urbain, dans différentes régions du Québec, et réalisé une analyse thématique. Les résultats montrent un vécu globalement positif pour les parents, qui toutefois rencontrent de gros défis quant à l’accessibilité aux services de santé et sociaux pour leurs enfants. Des recommandations sont discutées afin d’améliorer l’expérience des jeunes TDG vivant en région ainsi que de leurs parents.
Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases
Authors: Funabiki Hironori , Wassing Isabel E. , Jia Qingyuan , Luo Ji-Dung , Carroll Thomas
Published: September 2023

5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. The mammalian SNF2 family ATPase HELLS and its plant ortholog DDM1 are critical for maintaining 5mC. Mutations in HELLS, its activator CDCA7, and the
de novo
DNA methyltransferase DNMT3B, cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome, a genetic disorder associated with the loss of DNA methylation. We here examine the coevolution of CDCA7, HELLS and DNMTs. While DNMT3, the maintenance DNA methyltransferase DNMT1, HELLS, and CDCA7 are all highly conserved in vertebrates and green plants, they are frequently co-lost in other evolutionary clades. The presence-absence patterns of these genes are not random; almost all CDCA7 harboring eukaryote species also have HELLS and DNMT1 (or another maintenance methyltransferase, DNMT5). Coevolution of presence-absence patterns (CoPAP) analysis in Ecdysozoa further indicates coevolutionary linkages among CDCA7, HELLS, DNMT1 and its activator UHRF1. We hypothesize that CDCA7 becomes dispensable in species that lost HELLS or DNA methylation, and/or the loss of CDCA7 triggers the replacement of DNA methylation by other chromatin regulation mechanisms. Our study suggests that a unique specialized role of CDCA7 in HELLS-dependent DNA methylation maintenance is broadly inherited from the last eukaryotic common ancestor.
Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics
Authors: Walker Timothy J , Reyes-Alvarez Eduardo , Hyndman Brandy D , Sugiyama Michael G , Oliveira Larissa CB , Rekab Aisha N , Crupi Mathieu JF , Cabral-Dias Rebecca , Guo Qianjin , Dahia Patricia LM , Richardson Douglas S , Antonescu Costin N , Mulligan Lois M
Published: September 2023

Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be caused by activating mutations of the rearranged during transfection (RET) receptor tyrosine kinase, or inactivation of TMEM127, a transmembrane tumor suppressor implicated in trafficking of endosomal cargos. However, the role of aberrant receptor trafficking in PCC is not well understood. Here, we show that loss of TMEM127 causes wildtype RET protein accumulation on the cell surface, where increased receptor density facilitates constitutive ligand-independent activity and downstream signaling, driving cell proliferation. Loss of TMEM127 altered normal cell membrane organization and recruitment and stabilization of membrane protein complexes, impaired assembly, and maturation of clathrin-coated pits, and reduced internalization and degradation of cell surface RET. In addition to RTKs, TMEM127 depletion also promoted surface accumulation of several other transmembrane proteins, suggesting it may cause global defects in surface protein activity and function. Together, our data identify TMEM127 as an important determinant of membrane organization including membrane protein diffusability and protein complex assembly and provide a novel paradigm for oncogenesis in PCC where altered membrane dynamics promotes cell surface accumulation and constitutive activity of growth factor receptors to drive aberrant signaling and promote transformation.