bluuebunny/crossref_metadata_2025 huggingface dataset:
İKİNCİ MEŞRUTİYET SONRASI TÜRK KADINININ SOSYAL VE KÜLTÜREL HAYATI
Authors: Yüce Sefa
Published: August 2024

Türk kadını, Tanzimat dönemi ile başlayan değişim sürecinde önemli ilerlemeler kaydeder. Bu süreç, II. Meşrutiyet sonrası daha da hızlanır. Bu dönemde, sosyal ve kültürel hayat yeni bir boyut kazanır ve kadından söz eden süreli yayınlar çoğalır. Kamuoyunda, kadınının eğitim durumu ve statüsü tartışılmaya başlanır. Kadın dernekleri kurulur ve zamanla kadınlar örgütlenir ve hak talebinde bulunurlar. Balkan ve Birinci Dünya Harbi, Türk toplumunda büyük tahribata yol açar. Memleket işgal edilir. Mütareke yıllarında, iş gücü açığını gidermek için kadınlara ihtiyaç duyulur. Kadınlar, çalışma hayatının aslî unsuru hâline gelir. Millî Mücadele döneminde, ordunun levazım ihtiyacını karşılamada önemli sorumluluklar üstlenir. Ayrıca Türk kadını, ilk kez posta hizmetinde görev alarak kamusal alana adım atmış olur. Mustafa Kemal, İstiklâl Harbi’nin en kritik aşamasında öğretmenlerle yaptığı toplantıda kadının eğitimi ve gelecekteki konumu üzerinde durur. Cumhuriyet’in ilanı birlikte Türk kadını sosyal-kültürel ve kamusal alanda önemli kazanımlar elde eder. Mustafa Kemal, Türkiye’nin inşasında kadını lokomotif unsur olarak görür ve onu geniş haklarla donatır. Bu çalışmada, II. Meşrutiyet sonrası Türk kadınının konumu ele alınmaya çalışıldı.
THE IMPACT OF VIRTUAL COMMUNITIES AND ETWINNING ACTION ON THE EDUCATION SYSTEM AND THEIR IMPLEMENTATION IN CLASSROOMS
Authors: Döğer Mehmet Fatih
Published: August 2024

This article is a part of a doctoral dissertation title with “Teachers in Social Networks” supervised by Prof. Dr. Mustafa Sever. This study aims to discuss the role of virtual communities and social networks in the future of education, aiming to uncover their usage in education. The quantitative aspect of the research, conducted through a mixed-method approach, includes an online survey directed at 6,005 teachers actively engaged in social networks. Data collected through the survey were analyzed using frequency distributions, mean scores, and percentages. In the qualitative component of the study, online interviews were conducted with twenty-five teachers serving in different regions of Turkey, across various subject areas and grade levels. The findings of this study indicate a vital role of social networks in helping teachers stay current, track changing and evolving trends, and enhance their personal and professional development. Teachers perceive these networks as valuable resources for disseminating information acquired from social networks and colleagues to their classrooms. However, the research also highlights teachers' concerns regarding security and privacy issues on social networks. It is anticipated that the proposed digital platform will serve as a source of inspiration and guidance for academics, practitioners, and existing literature alike.
Effects of interactive learning module technology on Kazakh as a second language learners’ achievement and communication skills
Authors: Yermekbayeva Gulmira , Kuzembayeva Gulzhana , Maydangalieva Zhumagul , Spulber Diana
Published: August 2024

This study aimed to investigate the effectiveness of interactive learning module technology (ILMT) in teaching Kazakh as a second language in secondary schools in the Republic of Kazakhstan. This research was carried out at Russian-medium secondary schools during the academic year 2021-2022. There were two groups in the sample: the experimental (n=63) and control (n=61). The experimental group received an education based on the ILMT while the control group received an education based on the curriculum's traditional technique. The study used a mixed research design and was divided into two sections: quantitative and qualitative. A semi-experimental pre- and post-test control group design was adopted in the quantitative section. The qualitative section employed phenomenology. The quantitative data were acquired using the students' knowledge assessment test and analyzed using comparative analysis. An interview questionnaire and observations were used to obtain qualitative data which was then evaluated using content analysis. The experimental group outperformed the control group in terms of mean post-test knowledge assessment test scores. The ILMT in teaching Kazakh as a second language is efficient in improving the quality of mastering Kazakh language by Russian-speaking students. Content analysis showed that the ILMT helps to reduce students' anxiety and increase independence which is necessary for the development of students' communication skills.
Single nucleotide polymorphisms: A paradigm in oral disease research
Authors: Ummer Hiba , Santosh Arvind Babu Rajendra , Surboyo Meircurius Dwi Condro , Chitipothu Mani Deepthi , Sivanandham Shamala
Published: August 2024

Background: A higher occurrence of oral cancer is observed in South Asian and Southeast Asian countries when compared with other countries in the world. Cancer, a disease with complex pathophysiology, has been linked to chronic inflammation. Inflammation has been considered an important component of tumor initiation and progression. This is supported by the fact that many cancers arise at the sites of chronic inflammation, but the exact mechanism by which inflammation influences cancer is unknown. Purpose: This review article correlates single nucleotide polymorphisms (SNPs), chronic inflammation, and oral cancer. The article emphasizes the critical role that SNPs play in oral cancer susceptibility, progression, and prognosis. This involves discussing the impact of specific SNPs on oral cancer risk and patient outcomes. Review: Gene polymorphism has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. Genetic variation has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. SNPs have been documented in inflammatory conditions as well as in various diseases. Conclusion: SNPs have phenotypic consequences and therefore can serve as genetic fingerprints. The upregulation or downregulation of genes is able to drive oral carcinogenesis.
Improving the Value of Major Courses for Graduating Quantitative Versus Qualitative Business Major Students
Authors: Blau Gary , Chitturi Pallavi
Published: August 2024

Using two independent academic cohorts, i.e., Fall 2021-Spring 2022 (n = 356) and Fall 2022-Spring 2023 (n = 180) of graduating business students, the relationship of an open item, “what do you believe could have improved the value of your major course experience?”, was asked to both quantitative majors and qualitative majors. Individual majors were coded into broader quantitative and qualitative major categories. The Fall 2021-Spring 2022 sample was broken down into n = 219 quantitative business majors and n = 137 qualitative business majors. The Fall 2022–Spring 2023 sample was broken down into n = 112 quantitative business majors and n = 68 qualitative business majors. Analysis across this open item for both samples of quantitative majors revealed that curriculum improvement was more desired over employment applicable skills. However, the opposite result was found for both samples of qualitative majors, increased employment applicable skills over curriculum improvement. Having improved instruction, e.g., more engaged professors, was a common theme across both majors in both years.
The toxic legacy of artisanal and informal mining: XRF and gis analysis of soil contamination by Hg, Pb and As in the Secocha annex, Camaná, Peru
Authors: Vargas Fernández Carlos Eduardo , Minaya Lizárraga Armando Adolfo , Málaga Cornejo Miriam Vilma María
Published: August 2024

Hg, used as the main input in the gold amalgamation process in artisanal mining, along with lead Pb and As present in the toxic waste resulting from mining activity, cause serious effects on the environment and human health, as it occurs in the Secocha annex (Camaná, Peru). The objectives of the present study were to determine the concentrations of Hg, Pb, and As in the soil of the Secocha annex, evaluate the level of contamination of the site, determine the spatial distribution of contamination and the concentrations of the evaluated elements, and determine the origin of these contaminants. To achieve these objectives, satellite imagery, field sampling, X-ray fluorescence techniques, soil quality environmental regulations, geo-accumulation indices (Igeo), and geographic information system techniques were used. The results revealed maximum concentrations of 350 and 176.6 mg/kg for Hg and Pb, respectively. Of the 72 soil samples collected, the concentrations of Hg located within the urban/industrial area, where gold recovery activities are carried out, exceeded environmental regulations to a greater extent. In turn, the calculated Igeo revealed extreme soil contamination (5 < Igeo) due to the presence of Hg in most of the study area (95%), followed by moderate to heavy contamination (2 < Igeo < 3) due to the presence of Pb and As (0.5 and 5%, respectively). To reduce contamination and the concentrations of the evaluated elements, it is recommended to carry out studies to reuse inputs, change gold processing methodologies, and/or relocate the generated waste.
Orthopaedic Injury Patterns in Intimate Partner Violence: Defensive Wounds and Fracture Patterns
Authors: Willson Roan , Roddy Erika , Martinson Holly , Skelton Caitlin Farrell , Taitsman Lisa
Published: August 2024

Background:

Intimate partner violence (IPV) is a prevalent issue in the United States, despite universal screening measures for women of reproductive age. Orthopaedic surgeons have a unique opportunity to intervene in cases of IPV as musculoskeletal injuries, including fractures, are the second most common type of injury seen in IPV patients. This systematic literature review aims to identify patterns in musculoskeletal injuries caused by IPV to increase identification of patients afflicted by IPV.

Methods:

A comprehensive search of PubMed, PsycINFO, and Web of Science yielded 316 articles. Included were cohort studies and literature reviews of patients with an IPV-associated orthopaedic injury. Excluded were case studies, perspective articles, material predating 2003, and studies with pediatric or elderly populations. Sixteen articles met criteria.

Results:

Data supported historical findings that musculoskeletal injury is the second most common injury in patients with IPV, with upper extremity fractures prevailing. Minimally displaced phalanges fractures were most common (9.9%-64%), and isolated ulnar fractures had significant relative risk of IPV association (8.5-12.8). Patients with multiple fractures of varying chronicity were more likely to be victims of IPV (sensitivity 25.2%, specificity 99.2%, positive predictive value 96.2%), and these chronic fractures matched patterns of acute injury caused by IPV. New findings in male victims included a higher proportion of lower extremity and pelvic fractures seen in male cohorts.

Conclusion:

This study synthesizes evidence of IPV-related orthopaedic injuries, offering objective criteria for identifying victims. Despite limitations in fracture descriptions, the findings aid various physicians in recognizing IPV victims. Considering ongoing IPV prevalence and screening challenges, further research on injury patterns is recommended.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
From Cement to Bismuth: Perfecting the Perforation Wash Technique
Authors: Kuyken C. , Carragher P. , Spurr J. , Alves B. , Talapatra Didhiti , Ezani F. S. , Kumar A. , Razak M. , Hamid A. , Lau Chee hen
Published: August 2024

This SPE contribution provides a comprehensive explanation of the optimization of well performance through an innovative approach, refining the conventional Perforating, Wash, and Cement Technique by introducing an alternative metal-to-metal seal with a Bismuth Alloy plug. This pioneering method offers a transformative approach towards future Plug and Abandonment strategies.

The selection of the Bismuth alloy plug, rather than opting for a conventional plug barrier, stemmed from a meticulous evaluation of the specific project requirements and challenges while emphasizing the unique advantages and capabilities offered by this alternative approach. Bismuth alloy plug effectively addresses the complex and dynamic needs of the operation as well as serves as an innovative solution to sealing off the gas leaks from one of the offshore platforms in the Southeast Asia region.

The implementation of the Bismuth alloy plug has demonstrated a paradigm shift in the P&A process and integrity of the well barrier system. Not only that, it has also heralded a significant transformation by reducing the required P&A plug length.

Not only were operations expedited, but a substantial reduction in operational complexities was achieved. This transformative approach effectively addressed challenges and intricacies traditionally associated with conventional methods, streamlining the process while upholding the highest standards of safety and performance.
Successful Implementation of Barrier Device Glass Plug Technology for Enhancement of Well Barriers Assurance Process
Authors: Tleulin Artur , Alromaithi Khaled Butti Suhail Manea , Hussain Mohamed Qassem , Marzouqi Muna Al , Iglesias Danilo
Published: August 2024

This technical paper presents valuable insights and recommendations related to Barrier Devices, commonly known as Glass Plugs, which have been extensively utilized by the largest UAE Oil and Gas Operator to enhance well integrity assurance.

In 2019, the Operator revised its internal Company procedures for verifying completion barriers during well construction. These revisions aligned the practices with international industry standards. As part of this enhancement, the use of Barrier Devices (specifically Glass Plugs) became mandatory during the installation of upper completions in wells capable of establishing natural flow. The decision to adopt Barrier Devices was driven by the need to address challenges associated with conventional slickline operations, including stuck plugs and limitations in depth accessibility due to high inclination angles.

From the beginning of 2023 Operator successfully completed over 400 wells, utilizing Barrier Devices for setting production packers and conducting inflow tests on downhole safety valves. Notably, the Operator emerged as a major global consumer of Barrier Devices, not just within the Middle East.

Access to Barrier Device technologies from various vendors allowed the Operator to accumulate extensive experience with different types of Barrier Devices—ranging from mechanically removed to remotely activated options, each with varying metallurgies and sizes. These Barrier Devices were effectively integrated into Upper (Cased Hole) Completions, serving as an alternative to traditional slickline plugs.

The extensive use of Barrier Devices led the Operator to compile a comprehensive database of lessons learned and practical recommendations. This knowledge is invaluable for future deployments of this novel technology. Additionally, close collaboration with Barrier Device vendors facilitated operational efficiency improvements, enhanced equipment reliability, and ensured alignment with the Operator's Drilling Plan, meeting HSE and well integrity requirements.

Despite a long term existence of glass plug technology on the market, comprehensive details on the selection and efficient usage of these completion tools remain scarce. By sharing insights into technology principles and best practices based on end-user experiences, this paper should benefit other industry professionals.
Mechanical Behavior and Comprehensive Optimization Design of Drill String with Drag Reduction Oscillators in Horizontal Drilling
Authors: Shi Xiaolei , Huang Wenjun , Huang Jincheng , Gao Deli , Ren Qianying
Published: August 2024

The efficiency and safety of drilling operations have increasingly been limited by the friction and torque of the drill string in horizontal wells. Drag reduction oscillators have shown in practice to efficiently lower the drill string's friction force, accelerate rate of penetration, and raise the extension limit. Nonetheless, there is still more to explore on the drill string with drag reduction oscillators’ mechanical behavior and thorough optimization design.

The primary objectives of this paper are stick-slip suppression efficiency and drag reduction efficiency. Taking into account the strong nonlinearity of the friction force and introduction of definite conditions, the model of drill string with drag reduction oscillators is established. Taking into account the torque loss and rotary speed control, the stick-slip vibration model with oscillators is also established. By using an orthogonal test design, the key determinants influencing the stick-slip suppression efficiency and drag reduction efficiency were identified, along with the propagation distance model and the optimal installation location model. Furthermore, the optimal drag reduction parameters and stick-slip suppression parameters are recommended, taking into account drill string buckling, fatigue failure, and hydraulic loss. All the above approaches were utilized in China Jimsar oilfield.

The results demonstrate that the oscillator can efficiently decrease friction force while improving the WOB. The proximity of the oscillator to the drill bit directly correlates with the efficiency of drag reduction. The efficiency of drag reduction is mostly affected by the number of oscillators and the corresponding amplitude, while stick-slip suppression performance is primarily influenced by the rotational speed and WOB. Increasing the rotational speed has greater impact on preventing stick-slip than decreasing the WOB. In this case, it is advisable to install three oscillators with an amplitude of 40 kN, which increases the efficiency of drag reduction by 37.5%. When the optimum rotation speed is 162 r/min and the WOB is 171 kN, the efficiency of the stick-slip suppression is improved by 12.1 %. This study has significant implications for the risk control in horizontal drilling operations and the optimal design of oscillators.
Engineering Design Solutions of Drilling Fluid and Cement Slurry for a Challenging Deep HPHT Carbonate Appraisal Well in Malaysia
Authors: Ong G. S. H. , Chan L. , Ho A. , Udin R. , Kunjirama M. , Nilpetploy V. , Thanasarnpisut V. , Duong A. , Azwar C.
Published: August 2024

Well construction in deep high-pressure, high-temperature (HPHT) carbonate wells typically impose the most restrictive restraints and essential requirements for drilling fluid and cementing design and application. This type of well presents specific challenges and difficult technical concerns that must be addressed not only in the drilling phase of the well but also on the long term well integrity. Drilling exploration or an appraisal well accentuates these challenges as formation details may not be fully understood.

A recent appraisal well located in offshore Malaysia, presents many challenges especially on the drilling and cementing into its carbonate formation. Among the challenges of completing this HPHT well are high CO2 and H2S exposure, tight equivalent circulating density (ECD) concerns during drilling and cementing, losses from weak interbedded sands and severe losses concerns across its carbonate sections (Karst formation). In the HPHT section of this well, HPHT non-aqueous fluid (NAF) system was designed to meet the criteria for drilling and well test. Also, specially designed self-healing, high temperature flexible and expandable cement was engineered due to concerns of formation subsidence. This set cement design provides flexible properties to cater stress induced by formation movements, coupled with self-healing properties ensuring long term well integrity with its self-repair capabilities. A comprehensive and collaborative approach between drilling fluid and cementing design was among the pivotal factor ensuring the successful well construction of this appraisal well.

This paper presents the complete engineering process from coherent well construction planning, drilling fluids and cement slurries design, rigorous laboratory validation, drilling and cementing hydraulic modeling, preventive and collective loss circulation control to successful well drilling execution. It also summarizes the lessons learnt from the operation and recommendations to drill and construct future wells under HPHT environment in this field.
Coiled Tubing Downlines Corrosion and Preservation Experience from Extended Riserless Light Well Intervention Campaigns
Authors: Mammadli R. , Charles E. , Duenas J. , Ramnath L. , Adilov R. , Law M. , Elliott K. J. , Smith R. W.
Published: August 2024

Riserless Light Well Intervention (RLWI) is becoming a more prevalent means to complete needed intervention scopes in deepwater subsea well environments. This is enabled by application of coiled tubing (CT) as downline in a marine environment to facilitate fluid pumping operations versus conveyance through a riser-based system. However, this technique introduces additional factors that affect CT corrosion and service life.

In collaboration with CT supplier Halliburton, bp decided to implement a conservative 6-month CT replacement schedule. The objective of this study was to inspect CT recovered from recent campaigns to evaluate if the 6-month frequency of replacement was fit for purpose.

A coiled tubing (CT) downline inspection was performed on strings recovered from RLWI operations in deepwater Gulf of Mexico (GoM). The CT was sent to the manufacturer for both visual and Electromagnetic Inspection (EMI) analysis to understand the life degradation due to corrosion from exposure to the marine environment. The entire length of coiled tubing was run through the EMI inspection sensor to measure wall thickness and determine the pitting severity.

The visual inspection indicated severe external pitting and corrosion at various sections of CT. Therefore, the pipe was taken out of service and sent for inspection. The initial assessment suggested the marine environment was primarily responsible for the degraded condition. Based on the results and comparison with other CT downline applications from RLWI operations in North Sea and West Africa, the CT replacement and inspection frequency was reevaluated for deepwater GoM. Additionally, improvement opportunities for CT preservation were considered.

CT life degradation during unconventional and consistent use in open water is not widely understood in the industry. As of now, guidelines are not available for application as downline in RLWI operations. The results help to improve understanding, pursue improvement opportunities, and investigate currently conservative approaches while ensuring CT integrity and prevention of RLWI operational failures.
The Efficacy of Rapamycin in Spinal Cord Injury: A Systematic Review and Meta-Analysis of preclinical studies
Authors: Zarei Hamed , Azimi Amir , Ramawad Hamzah Adel , Hajisoltani Razieh , Yousefifard Mahmoud
Published: August 2024

Background
Rapamycin has shown a potential role in functional and neurological recovery after neurodegenerative disease. The current study evaluates the efficacy of Rapamycin in preclinical spinal cord injury (SCI).
Methods
A systematic literature search was conducted in Medline, Embase, Scopus, and Web of Science databases until April 2023. Inclusion criteria were preclinical studies comparing Rapamycin treatment to a control group in animal models of SCI and reporting outcomes including locomotion, apoptosis, autophagy, inflammation, astrogliosis, neuronal counts, and signaling proteins related to the mechanistic target of Rapamycin in Akt/mTOR/p70S6K pathway. Two independent reviewers performed study screening and data extraction. For meta-analyses, a standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated for each experiment and a pooled effect size was reported. The risk of bias and certainty of evidence was assessed using SYRCLE and GRADE tools, respectively.
Results
18 papers were included in the study. Rapamycin significantly decreased apoptosis (TUNEL: SMD − 3.44, 95% CI -5.41 to -1.47; Caspase-3: SMD − 3.85, 95% CI -7.57 to -0.13), inflammation (TNF-α: SMD − 3.26, 95% CI -5.56 to -0.97), astrogliosis (GFAP: SMD − 0.76, 95% CI -1.28 to -0.25), and inhibited Akt/mTOR/p70S6K signaling pathway (SMD − 3.74, 95% CI -6.31 to -1.18). It increased autophagy markers (Beclin-1: SMD 1.42, 95% CI 0.51 to 2.33; LC3-II: SMD 1.09, 95% CI 0.35 to 1.82) and neuronal counts (SMD 1.18, 95% CI 0.44 to 1.91). Locomotion was not significantly influenced by the short-term effects of Rapamycin. However, treatment had significant long-term improvements in locomotion (SMD 0.74–1.54 from 1–6 weeks).
Conclusion
The current study indicates Rapamycin provides neuroprotection, reduces inflammation, enhances autophagy, and improves long-term locomotion in rodent SCI models.
Measurement of Systemic Risk Based on the QRDCCNN Model
Authors: LI JUCHAO , SHENG JILIANG , HUANG YI
Published: August 2024

Measuring and preventing systemic risk have always been core issues in finance. To accurately capture systemic risk, this is the first introduction of the Quantile Regression Dilated Causal Convolution Neural Network (QRDCCNN) model for assessing systemic risk. This model focuses on the causal consistency of financial time series and effectively expands the model's receptive field by increasing the dilation rate layer by layer. The study selects the daily closing prices of the S\&P 500 index and 38 US financial institutions as subjects. The QRDCCNN model is employed to measure the VaR of each financial institution and the CoVaR of the financial system when these institutions are in extreme risk conditions. This paper compares the results of the QRDCCNN model with those from the DCC-GARCH, quantile regression, QRNN, and QRCNN models using the Kupiec test. The research results show that the QRDCCNN model has the highest accuracy, followed by QRNN and QRCNN models, while the DCC-GARCH model has the lowest accuracy.
Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis
Authors: Li Meng , Li Jun , Wang Ying , Jiang Guancheng , Jiang Hanguo , Li Mengdi , Zhu Ziying , Ren Fangli , Wang Yinyin , Yan Muyang , Chang Zhijie
Published: August 2024

Background
Idiopathic Pulmonary Fibrosis (IPF) is a type of interstitial lung disease characterized by chronic inflammation due to persistent lung damage. Mesenchymal stem cells (MSCs), including those derived from the umbilical cord (UCMSCs) and placenta (PLMSCs), have been utilized in clinical trials for IPF treatment. However, the varying therapeutic effectiveness between these two MSC types remains unclear.
Methods
In this study, we examined the therapeutic differences between UCMSCs and PLMSCs in treating lung damage using a bleomycin-induced pulmonary injury mouse model.
Results
We showed that UCMSCs had a superior therapeutic impact on lung damage compared to PLMSCs. Upon cytokine stimulation, UCMSCs expressed higher levels of inflammation-related genes and more effectively directed macrophage polarization towards the M2 phenotype than PLMSCs, both in vitro and in vivo. Furthermore, UCMSCs showed a preference for expressing CCL2 and CXCL1 compared to PLMSCs. The expression of SPP1, Trem2, and Cebpb in macrophages from mice with the disease treated with UCMSCs was significantly reduced compared to those treated with PLMSCs.
Conclusions
Therefore, UCMSCs demonstrated superior anti-fibrotic abilities in treating lung damage, potentially through inducing a more robust M2 polarization of macrophages than PLMSCs.
Barriers and facilitators to using feedback from clinical quality registries: A systematic scoping review protocol
Authors: Al-Qarni Hussein , Allida Sabine , McDonagh Julee , Ferguson Caleb
Published: August 2024

Background
A clinical quality registry (CQR) is a structured database that systematically collects data to monitor clinical quality and improve healthcare outcomes. The aims of CQRs are: to improve treatment plans, assist in decision-making, increase healthcare value, enhance care quality, and reduce healthcare costs by providing feedback to healthcare providers. Feedback to clinicians is used as a quality improvement tool. It provides data to clinicians about their performance, which may contribute to improvement in healthcare outcomes. To the best of our knowledge, previous research on CQRs has primarily focused on factors affecting their use and their impact on healthcare outcomes. In this study, a systematic scoping review is conducted to understand the barriers to and facilitators of using feedback systems from clinical quality registries in acute healthcare settings.
Methods
For this review, Arksey and O’Malley’s framework for scoping reviews will be applied. The following electronic databases (MEDLINE via Ovid, CINAHL, and Scopus) and grey literature (Google Scholar) will be systematically searched for qualitative and mixed-method studies (only including qualitative findings) published after 2000 in the English language. Two reviewers will independently screen the articles and extract the data which, subsequently, will be mapped against the COM-B model.
Discussion
This review is conducted with the aim of providing valuable insights into the factors that influence the utilisation of feedback from Clinical Quality Registries, which in the context of quality improvement, may have significant implications for clinical research, registry science, health policy, and clinical practice.
Systematic review registration:
This protocol has been registered prospectively with the Open Science Framework (OSF) (https://osf.io/fhm4n/ ).
Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial
Authors: Al-Husseini Ali , Tegner Yelverton , Blennow Kaj , Zetterberg Henrik , Marklund Niklas
Published: August 2024

Background
Head impacts are common in contact sports such as boxing and occur at times of elevated core body and brain temperatures induced by the exercise. Following impact, elevated brain temperature may lead to the development of exacerbated brain injury that can be monitored by blood biomarkers. We hypothesized that acute head-and-neck cooling, recently shown to shorten return-to-play in concussed ice hockey players, applied acutely following a boxing bout is associated with an attenuated release of blood biomarkers and improved symptom rating.
Methods
The trial is academically driven and funded by external and hospital research funds. Young, healthy elite boxers ≥ 18 years old are recruited. Prior to, and immediately after a competitive boxing bout over 3x2 or 3x3 minutes, blood samples are drawn. Boxers are randomized to intervention or control management by 1:1 allocation prior to baseline testing. After the initial post-fight blood sample is drawn and symptom rating using the sports concussion assessment tool-5 (SCAT-5) has been collected, the boxers receive either acute selective head-and-neck cooling for 45 min, or routine post-fight management. The number of head impacts are counted in all boxers on match video recordings. In both groups, blood samples are drawn 45 minutes after the initial post-bout blood sample, as well as 3 and 6 days post-fight. At all time points for blood sampling, the number of symptoms (NOS) and symptom severity score (SSS) are assessed using the symptom rating part of the SCAT-5. The primary endpoint is the difference in biomarker levels (GFAP, NF-L, tau, UCH-L1, neuronal-specific enolase) between immediately post-fight and pre-intervention levels, to those obtained at 6 days post-fight. The post-fight SCAT-5 NOS and SSS are secondary endpoints.
Discussion
There is no treatment available for boxing-induced brain injury. Biomarkers are surrogate yet objective marker of brain injury, and the head-and-neck cooling treatment may attenuate the release of brain injury-related biomarkers as well as reduce symptoms induced by head impacts attained during a boxing fight. Potentially, head-and-neck cooling is a treatment option acutely following a boxing bout.
Trials registration
ClinicalTrials.gov, ClinicalTrials.gov Identifier NCT06386484. Registered April 23, 2024.
Dual functional In2O3-PANI-PEDOT Hybrid for Sensing Gallic Acid and Photocatalytic Degradation of Methylene Blue
Authors: Settu Munusamy , Govindhan Gnanamoorthy , Thirugnanam Bavani , Vengidusamy Narayanan
Published: August 2024

In this study, we have investigated the electrocatalytic properties of a nanohybrid composed of In2O3 nanoparticles and a copolymer of PEDOT-PANI. In2O3 nanoparticles, synthesized at 20 and 50 nm sizes, were combined with PANI-PEDOT to form a nanocomposite. The electrocatalytic activity of the nanohybrid was evaluated through catalytic studies using gallic acid (GA) as a model analyte and employing differential pulse voltammetry (DPV). The modified glassy carbon electrode (GCE) exhibited linear responses towards GA in the concentration range of 0.2×10−8 to 1.2×10−9 M, with a sensitivity of 3.102 µA/µM cm−2. The detection limit (DL) and quantification limit (QL) were determined to be 1.108×10-9 and 2.1810×10-9 M µA-1, respectively, indicating the suitability of the nanohybrid for electrochemical sensing applications. Additionally, the nanocomposite demonstrated promising photocatalytic activity, with a maximum efficiency of 98.9% towards methylene blue (MB) degradation within 60 minutes. The interference of reactive hydroxide ions (OHo) formed during the degradation process was observed but did not significantly affect the overall performance. This study highlights the potential of In2O3-PANI-PEDOT nanocomposite for use in electrochemical sensing and photocatalytic applications, with opportunities for further optimization and development of hybrids.
Enhancing Embedding Capacity of Linguistic Steganography Using Arabic Calligraphy
Authors: hamzah Ali A.
Published: August 2024

The limited quantity of redundancy bits in text and the ease with which little alterations may be detected make text a difficult medium for steganography. Linguistic steganography involves hiding data using linguistic characteristics. A language's capability for change increases opportunities to hide information. Many Arabic language elements are currently underutilized in text steganography while being abundant. An assortment of typefaces and forms are used for the Arabic alphabet, for instance in Arabic calligraphy. In this paper, we use the Arabic language's feature extension character (Kashida) with Arabic letter shapes and white space to hide secret bits. This modification uses a linguistic steganography framework that utilizes Arabic calligraphy (AC-STEGA). It tweaks a string-matching algorithm and produces Arabic stego text by a hidden message. In the presented work, a Kashida letter, white space, and multiple shapes of letters based on Arabic font (Naskh) as a case study are employed to hide secret information and increase the capacity of hiding data. The evaluation showed an improvement of 67.3% in capacity compared to 65.4% and 25.4% presented in previous and other similar works. On the security side, the cover represents the secret message itself, so there is no cover used.
YY1 downregulation underlies therapeutic response to molecular targeted agents
Authors: Zhuang Guanglei , Zhou Shichao , Zang Jingyu , Cai Meichun , Ye Kaiyan , Liu Jin , Ma Pengfei , Wu Jie , Dai Chenyang , Lu Haijiao , Zhang Qing , Chu Тianqing , Shen Ying , Tan Li , Zhao Xiaojing , Zhuang Yu , Fu Yujie
Published: August 2024

During targeted treatment, oncogene-addicted tumor cells often evolve from initial drug-sensitive state through a drug-tolerant persister bottleneck towards the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory is not completely elucidated. Here, we employed a multifaceted approach and implicated a convergent role of transcription factor Yin Yang 1 (YY1) in the course of diverse targeted kinase inhibitors. Specifically, pharmacological perturbation of receptor tyrosine kinase (RTK)/mitogen-activated protein kinase (MAPK) pathway resulted in the downregulation of YY1 transcription, which subsequently resumed upon therapeutic escape. Failure to decrease YY1 subverted cytotoxic effects, whereas eliminating residual YY1 maximized anticancer efficacy and forestalled the emergence of drug resistance. Mechanistically, YY1 was uncovered to dictate cell cycle and autophagic programs. Immunohistochemical analysis on a wide spectrum of clinical specimens revealed that YY1 was ubiquitously expressed across lung adenocarcinomas and exhibited anticipated fluctuation in response to corresponding RTK/MAPK inhibition. These findings advance our understanding of targeted cancer management by highlighting YY1 as a determinant node in the context of genotype-directed agents.
One-step synthesis of Schiff base polymer doped with MWCNTs as electrode material for supercapacitors
Authors: He Mengyuan , Yu Min , Li Jieying , Zhang Mengjie , Xue Lili , Wang Wei
Published: August 2024

Schiff base polymer (TPB) and carbon nanotubes doping Schiff base polymers (TPB/MWCNTs-X, X = 2, 5, 8) were prepared by one-step synthesis method from 2,4,6-triamino-5-nitrosopyrimidine and 4,4'-biphenyldicarboxaldehyde. Scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy and Fourier transform-infrared spectroscopy were used to characterize the morphology and phase compositions. Sample TPB/MWCNTs-2 possess the optimal electrochemical performance, measurement results reveal that the specific capacitance of TPB/MWCNTs-2 electrode is 714 F g− 1 at a current density of 0.5 A g− 1 in the three-electrode system, and the capacity retention rate is still 76.6% in 5000 cycles with 10 A g− 1 current density. Furthermore, the asymmetric supercapacitor battery hybrid device (TPB/MWCNTs-2//AC) was established in 6 M KOH electrolyte with TPB/MWCNTs-2 and activated carbon (AC) serving as the positive and negative electrodes, respectively. The TPB/MWCNTs-2//AC device have the maximum energy density of 94.06 Wh kg− 1 with 0.5 A g− 1 current density, at the same time the device possesses 371.87 kg− 1 power density. Carbon nanotubes disrupted the π-π stacking of polymer molecular links and some microcosmic pore structures formed in the nanotubes doping process, and the carbon nanotubes are suitable for channeling of electrolyte ion diffusion from electrolyte solution body to the center of conductive polymer bulk.
Humic Acid Attenuates DSS-Induced Colitis, Increases MUC-2 Expression, and Restores Colonic Histoarchitectural Damage in Adult Male Wistar Rats
Authors: Omolaso Blessing Oluwagbamila , Adeniran Adeoti Gbemisola , Ogunmiluyi Oluwafunmbi Ebenezer , Adesanwo Julius Kayode , Akinwumi Adetutu , Ewonowo Kehinde , Akinsola Oluwatomiwa , Olorunnusi Temitope Abosede
Published: August 2024

This study investigates the role of humic acid (HA) in attenuating Dextran sulfate sodium (DSS)-induced UC in male Wistar rats. Twenty male Wistar rats were randomly assigned to groups (n = 5). Group 1 served as controls; Group 2 received 5% DSS alone; Group 3 received 5% DSS followed by humic acid (30 mg/kg); and Group 4 received 5% DSS followed by sulfasalazine (200 mg/kg). DSS was administered orally to induce colitis in Groups 2, 3, and 4. Colitis was induced for five days and drug treatment done for another 5 days Disease activity index was assessed on days 1, 3, 5, and 10. Animals were euthanized by cervical dislocation, colon specimens harvested for macroscopic assessment, histological and biochemical assays. Data were analyzed using one way ANOVA (p < 0.05). Results show humic acid treatment significantly attenuated DSS-induced colitis by reducing inflammation markers (TNF-α, interleukin-6, interleukin-1β, and arginase), lipid peroxidation (MPO) and restoring colonic histological integrity. Significant improvements were observed in colonic tissue nitrite levels and Muc-2 expression. Conclusively, HA shows promise as an alternative therapeutic for UC, offering antioxidant, anti-inflammatory, and mucosal barrier-protective effects.
Tumor Cell-Intrinsic Circular RNA CircFNDC3B Attenuates CD8+ T Cells Infiltration in Non-Small Cell Lung Cancer
Authors: Qiong Zhou , shan Wei , Xuan Xiang , lei Wang , hao Wang , jie Xing , bei Peng , lin Ye , Yue Qu , Long Chen , han Yang , yu Zhang , qian Xue , qi Ai , Ke Jiang
Published: August 2024

Tumor-infiltrating CD8+ T cells are related with a satisfactory immunotherapy efficacy and a survival benefit. However, the mechanisms underlying differential infiltration levels are largely unknown, especially the role of circular RNAs (circRNAs) involving in CD8+ T cells infiltration remain poorly understood. Here, we identify 9912 distinct circRNAs from four paired normal and tumorous tissues of non-small cell lung cancer (NSCLC). We discover that circFNDC3B, derived from exons 2 and 3 of the FNDC3B gene, is significantly upregulated in NSCLC. TFⅡ-I interacting with STAT1 could function as an activator of transcription, facilitating CXCL10 and CXCL11 expression. However, circFNDC3B could bind to TFⅡ-I forming an RNA-protein complexus, thereby competitively inhibited the interaction between TFⅡ-I and STAT1, decreased the level of CXCL10 and CXCL11, and restricted infiltration of CD8+ T cells eventually. Meanwhile, the mouse circFndc3b ortholog is also inversely correlated with the infiltration of CD8+ T cells, attenuating the PD-1 blockade therapy’s effectiveness. These results demonstrate a pivotal role of tumor cell-intrinsic circRNA in immune infiltration and validate circFNDC3B as a potential target to develop a better effective immunotherapy strategy of NSCLC.
Dynamic Compressive Behavior of Steel Fiber Reinforced Recycled Aggregate Concrete
Authors: Wei Fangfang , Chen Zhuoran , Shi Yilei , Luo Hao
Published: August 2024

Steel Fiber Reinforced Recycled Aggregate Concrete (SFRRAC) presents an innovative and sustainable alternative to promote environmental sustainability and resource efficiency.This paper reports an experimental study of the dynamic compressive behavior of SFRRAC with different volume contents under high strain rates (23.9 ~ 96.3s-1) .The Split Hopkinson Pressure Bar (SHPB) was applied for dynamic impact compression tests at different strain rates and indicated a significant strain rate strengthening effect on the dynamic compressive strength which demonstrated an increase ranging from 10–80% to prove that an increase in steel fiber contents can improve the material compressive behavior. Based on the improved Z-W-T model, the fitting error of the stress-strain curve of recycled concrete under impact load under different steel fiber content and different strain rate was only within 10%, which proved that the model has better fitting ability and can accurately describe the mechanical behavior of steel fiber recycled concrete under dynamic impact. The numerical simulation conducted using ANSYS/LS-DYNA offered a superior representation of the dynamic behavior and performance characteristics of concrete which proved the tendency of internal stress of recycled and the effectiveness and accuracy of impact simulation.
Sema4D Deficiency Enhances Glucose Tolerance Through Acceleration of GLUT2 Synthesis in Hepatocytes
Authors: Zhang Yanling , Jiang Xiaomei , Wu Dongsong , Huang Hao , Jia Guiqing , Zhao Gaoping
Published: August 2024

The glucose transporter 2 (GLUT2) is constitutively expressed in pancreatic beta cells and hepatocytes in mice. It is the most important receptor in glucose-stimulated insulin release and hepatic glucose transport. The Sema4D is a signaling receptor on cell membranes. The correlation between Sema4D and GLUT2 has not been reported previously. We investigated whether knockdown of Sema4D could exert a hypoglycemic effect based on the increased GLUT2 expression in Sema4D -/- mice hepatocytes. First, Sema4D -/- male mice exhibited significantly greater glucose tolerance than wild-type mice in a hyperglycemic environment. Secondly, Sema4D -/- mice had more retained GLUT2 in liver membranes after streptozotocin (STZ) injection according to an immunofluorescence assay. After STZ injection, Sema4D -/- male mice did not exhibit fasting hyperinsulinemia like wild-type mice. Finally, analysis of metabolomic and immunohistochemical data also revealed that Sema4D -/- mice produce hypoglycemic effects by enhancing the pentose phosphate pathway, but not glycogen synthesis. Thus, Sema4D may play an important role in the regulation of glucose homeostasis by affecting GLUT2 synthesis.
Synthesis of novel zeolite-supported zinc-cobalt bimetallic catalyst by co-precipitation-calcination method for efficient activation of persulfate to degrade tetracycline hydrochloride
Authors: Tang Chengjiao , Ren Dajun , Zhang Shuqin , Zhang Xiaoqing
Published: August 2024

Addressing the challenges posed by the high cost and limited efficiency of traditional Chinese medicine wastewater treatment, the development of a cost-effective and highly efficient catalyst for activating persulfate (PMS) to degrade organic pollutants holds significant practical importance. This research successfully synthesized a zinc-cobalt bimetallic catalyst supported on sepiolite (Zn-Co@SEP) using a straightforward co-precipitation-calcination method. Various characterization techniques, including scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy, validated the synthesis process. The introduction of sepiolite as a carrier provided additional active sites, facilitating the redox cycling of Co2+/Co3+ and Zn2+/Zn3+, which continuously generated reactive species. Zn-Co@SEP exhibited remarkable catalytic activity towards PMS, achieving a degradation efficiency of over 93% for TC (50 mg/L) within just 30 minutes in the Zn-Co@SEP/PMS system. The study systematically investigated the influence of Zn-Co@SEP dosage, PMS dosage, TC concentration, pH, and temperature on the degradation efficiency of the catalytic system. Notably, the Zn-Co@SEP/PMS system maintained high degradation rates for TC across a wide pH range (3–11) and demonstrated robust stability and recyclability, retaining a degradation rate of 89.56% after four cycles of reuse. Further experimental evidence from free radical quenching studies, electron paramagnetic resonance (EPR) experiments, and oxidative capacity potential (OCPT) results underscored the involvement of multiple radicals (1O2, SO4−•, O2−•, •OH) and electron transfer pathways in promoting TC degradation. In conclusion, this research contributes new insights into the synthesis of efficient PMS catalysts tailored for the degradation of antibiotic wastewater, addressing a critical need in environmental remediation.