bluuebunny/crossref_metadata_2025 huggingface dataset:
Ruxolitinib shows activity against Hodgkin lymphoma but not primary mediastinal large B-cell lymphoma
Authors: Kim Seok Jin , Yoon Dok Hyun , Kang Hye Jin , Hong Jung Yong , Lee Ho Sup , Oh Sung Yong , Shin Ho-Jin , Kong Jee Hyun , Yi Jun Ho , Sakamoto Kana , Ko Young Hyeh , Huh Jooryung , Lee Seung-Sook , Takeuchi Kengo , Shin Dong-Yeop , Suh Cheolwon , Kim Won Seog
Published: July 2019

Background

The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). Based on the hypothesis that JAK2 is a therapeutic target, we performed a prospective pilot study using ruxolitinib.

Methods

Relapsed or refractory patients with HL or PMBCL were eligible for this study, and JAK2 amplification was assessed by fluorescence in situ hybridization. Ruxolitinib was administered orally at a dose of 20 mg twice daily for a 28-day cycle. Treatment was continued for up to 16 cycles or until progressive disease or intolerability. The primary objective was to assess the overall disease control rate comprising complete response (CR), partial response (PR), or stable disease (SD).

Results

We analyzed 13 HL patients and six PMBCL patients. All responders (one CR, five PR, and one SD) had HL whereas all cases of PMBCL progressed after first or second cycle. The disease control rate for HL was 54% (7/13) with median response duration of 5.6 months. JAK2 amplification was present in six of nine patients tested (four HL, two PMBCL), and three of these HL patients showed PR (n = 2) or SD (n = 1). None of the three HL patients shown to not have JAK2 amplification responded to ruxolitinib. Most treatment-related adverse events were grade 1 or 2 and manageable.

Conclusions

Ruxolitinib has single-agent activity against HL but does not act against PMBCL with or without JAK2 amplification.
Phytoremediation of Cadmium-, Copper-, and Lead-contaminated Soil by Salix mucronata (Synonym Salix safsaf)
Authors: El-Mahrouk El-Sayed Mohamed , Eisa Eman Abdel-Hakim , Hegazi Mahmoud Abdelnaby , Abdel-Gayed Mohamed El-Sayed , Dewir Yaser Hassan , El-Mahrouk Mohammed Elsayed , Naidoo Yougasphree
Published: July 2019

Phytoremediation is an environmentally friendly and effective method of reducing contaminating ions to very low levels. In this study, the effects of different concentrations of cadmium (Cd), copper (Cu), and lead (Pb) on vegetative growth and the chemical and biochemical compositions of Salix mucronata as well as the potential for phytoextraction of these metals by plant organs were investigated. S. mucronata had the highest survival percentage (100%) in the presence of CdCl2, CuCl2, and Pb acetate up to 80, 200, and 850 mg·kg−1 in soil, respectively. A negative influence of these metals on vegetative and chemical parameters was observed relative to the control plants. The potential role of antioxidant enzymes in protecting plants from oxidative injury was examined by analyzing the antioxidant enzyme activities of plants grown in contaminated and control soils. Enzymatic activities and electrolyte leakage were higher in the plants grown in soil with increasing heavy metals than in the control plants. The bioconcentrating efficiency of Cd, Cu, and Pb in plant organs was estimated to be medium [bioconcentration factor (BCF) of 1–0.1]; an exception was the BCF of Cu in the roots, which was estimated to be intensive (BCF < 1). Concentrations of 60 mg·kg−1 CdCl2, 50 mg·kg−1 CuCl2, and 650 mg·kg−1 Pb acetate caused significantly higher translocation compared with other levels of each pollutant. The biomass tolerance index was less than 1. Additionally, S. mucronata accumulated Cd, Cu, and Pb in the following order: roots > stems > leaves. Therefore, the risk of contamination through leaf fall can be minimized. Therefore, S. mucronata could be a good candidate for phytoremediation of Cd-, Cu-, and Pb-contaminated soil.
Analysis and evaluation of consequences of emergency situations in Russia
Authors:   Irkutsk National Research Technical University, Garmyshev Vladimir V. , Timofeeva Svetlana S. ,   Irkutsk National Research Technical University, Dubrovin Dmitry V. ,   Department of the Emercom of Russia in Irkutsk region
Published: July 2019

The research object is man-made, natural, biological and social emergencies, and terrorism acts committed in the Russian Federation. The classification and quantitative assessment of emergencies by their type and scale were provided. Using the methods of social and mathematical statistics, a short-term comparative review of all types of emergencies in Russia for 2002-2017 was presented. Basic indicators (the number of ES, material damage, the number of deaths and injuries) were estimated. The comprehensive assessment of socio-economic impacts of emergency situations in Russia was presented. Taking into account the number of deaths and the number of the population, individual risks for all types of emergencies in Russia were estimated.
Possible directions for the development of bio-economy in Irkutsk region
Authors:   Irkutsk National Research Technical University, Panasenkova Elena Y. , Timofeev Semen S. ,   Irkutsk National Research Technical University
Published: July 2019

At the present stage of economic development, considerable attention is paid to the bioeconomy in order to ensure sustainable development. Bioeconomics is an economic mechanism for modernizing and building the post-industrial economy, including preservation and development of the bio-resource potential of the Russian Federation. The purpose of this work was to assess possibilities of bioeconomic development in Irkutsk region in terms of the use of renewable forest resources and its contribution to the gross regional product. Irkutsk region has unique forest resources and is one of the most densely forested among the subjects of the Russian Federation. Therefore, the most important specialization of Irkutsk region is the forest industry represented by timber logging, the production of deep processing products (lumber, fibreboard, chipboard, plywood), pulp-and-paper industry. In addition to large timber reserves, the forests of Irkutsk region have a high potential for the use of non-timber resources which can be a significant factor in bioeconomy. This is the preparation of resin; production of non-timber forest resources; preparation of food forest resources and collection of medicinal plants; implementation of activities in the field of hunting; farming; implementation of recreational activities; cultivation of forest fruit, berry, ornamental plants, medicinal plants, etc. The paper analyzed non-timber forest resources of Irkutsk region and determined their contribution to the gross regional product by the example of picking berries, ferns, mushrooms, etc. It is established that approximately 20% of the sale of forest is contribution of non-timber forest resources to the regional economy.
Current aspects of the cryptocurrency recognition in Ukraine
Authors: Fomina Olena , Moshkovska Olena , Avhustova Olena , Romashko Olha , Holovina Daria
Published: July 2019

Various mechanisms for implementation, and at the same time contradictory approaches to the essence, evaluation, reflection, and regulation, led to the need to consider and improve approaches to the recognition of cryptocurrency.
Based on the critical analysis of the legal provisions in Ukraine and the approaches of scientific experts, practitioners and international experience, the economic essence of cryptocurrency is substantiated. The legal, economic and accounting aspects of cryptocurrency recognition in developed and transformational economies are revealed. In order to meet the information needs of users, the peculiarities of the application of methods for estimating cryptocurrency commodities and the influence of the chosen method on the reflection of such an asset in the financial statements have been identified. The necessity to clarify and harmonize existing national accounting standards for recognizing and reporting on cryptocurrency transactions has been identified.
The proposed approach to the identification and recognition of cryptocurrency goods will improve the relations between the owners of cryptocurrency and the state, legalize cryptocurrency transactions and form an effective system for managing such transactions in Ukraine.
Household of the Special Settlers of Chechen Ethnicity in Semipalatinsk Region: Historical Sources Obtained from the Documentation Center of Contemporary History of Eastern Kazakhstan (Semey)
Authors: Atantaeva Bakyt Zh. , Mamayeva Gulnara Y.
Published: July 2019

The present paper features various sources obtained from the Documentation Center of Contemporary History of Eastern Kazakhstan (the city of Semey). The research objective was to draw a detailed picture of the resettlement and economic conditions that special immigrants from the North Caucasus had to face in the Semipalatinsk region of the Kazakh Republic during World War II. A source study analysis of the archive documents revealed various aspects of the subject in question. The documents were divided into several blocks: (1) information on the number and geography of the resettlement; (2) complex characteristics of the labor and economic household; (3) education and social security. The analysis of the documents showed that the placement of Chechens as special settlers led to extremely negative social and demographic consequences, causing an irreparable damage to their material and spiritual culture. Despite various economic, household, and labor measures, the deported people had to live in hard conditions.
The Little Entente in Russian Historiography
Authors: Martyushev Alexander V.
Published: July 2019

The research studies the Little Entente – the alliance formed by Czechoslovakia, Rumania, and Yugoslavia – and the impact it existed on the European politics during the Interbellum. The present paper focuses upon the way the Little Entente was described in domestic historiography. The author believes that Soviet historians concentrated mainly on the final stage of the alliance's existence. In that period, Germany was strengthening its positions in Central and South-Eastern Europe. Soviet historians paid attention to the growing disagreement between the members of the alliance associated with the activities of Germany, the USSR, and France in the region. After the collapse of the Soviet Union, Russian historians continued to develop the topics but gave more attention to the period of the formation of the Little Entente as a military bloc. Russian historians were more positive in their assessments of the alliance's activities related to its class characteristics and anti-Soviet character.
Method of Synchronized Fractal and Musical Dynamics as a Means to Achieve Altered States of Consciousness
Authors: Kabrin Valery I. , Vyskochkov Vladimir S. , Prudovikov Igor O. , Tkachenko Anatoly Y.
Published: July 2019

This paper continues the cycle of interdisciplinary studies that feature a new technology of audiovisual induction of altered states of consciousness. The technology is based on a combination of models, methods, and approaches of psychology, mathematics, and computer science. The research objective was to prove that the technology can induce relaxation states. The authors conducted two experiments with a specific configuration of synchronized fractal and musical sequences. The study involved 47 people, who were presented with audiovisual stimulation. Before and after the procedure, the panelists were presented with two sets of questionnaires to define their mental and emotional state. The results demonstrated significant negative changes on the demobilizing components: mental anxiety or resentment (N), mental depression and exhaustion (D) and depressed mood (S). The data analysis confirmed the hypothesis: the method can induce states of relaxation. The data obtained are can be used in further experiments, e.g. to reveal creative potential by means of audiovisual stimulation.
Psychical Process in Social Perception
Authors: Panferov Vladimir N. , Miklyaeva Anastasia V. , Bezgodova Svetlana A.
Published: July 2019

The research features the theoretical construct of the psychical process in social perception in line with the integrative approach to human psychology and social interaction. The author believes that psychical processes can be described as an integrative phenomenon of social perception. The psychical process is a multi-level system of mental activity, determined by mutual awareness of people in the process of joint activity and communication. There are three levels of the psychical process in social perception: gnoseological, semiotic, and phenomenological. The gnoseological level is described through the categories "reflection", "representation", "expression", and "experience"; semiotic level is presented by the categories "sign", "value", "meaning", and "relation"; the phenomenological level is indicated by the categories "identification", "apperception", "interpretation", and "portrait". The methodological value of the construct of psychical process realizes the principle of integrity in the learning of human psychology. The author outlines some prospects for future studies of ways and methods of the human psychological qualities and their refraction in the human individual psychology in the course of social interaction. The paper illustrates the prospective use of the construct in interpersonal perception studies.
Subjective Comfort, Coping-Strategies, and Types of Accentuations of Personality of Russian and Indonesian University Students
Authors: Yashchenko Elena F. , Lashchenko Daria A. , Lazorak Olga V.
Published: July 2019

This article introduces a comparative study of subjective comfort, coping-strategies, and types of accentuations of the personalities of Russian and Indonesian university students. The research employed the scale of subjective comfort assessment by A. Leonova, coping-test by R. Lazarus, and a test-questionnaire by G. Schmieschek and K. Leonhard. The experiment included 30 Russian and 30 Indonesian students (mean age – 20,5). The research revealed general qualities and differences between indicators of types of personality accentuations and ways of mastering stress. The students appeared to have no significant distinctions on the level of subjective comfort, which was normal. The Indonesian students distanced themselves and used self-control while facing stress more than Russian students. The most expressed types of personality accentuation of the Russian students were emotivity, demonstrativeness, and exaltation. As for the Indonesian students, it was pedantry. The subjective comfort of the Russian students had four interrelations with types of personality aссentuation, i.e. direct interrelations with emotive personality aссentuation and demonstrative and negative interrelations with obsessive and dysthymic personality aссentuations. There were three connections with coping-strategies, i.e. direct interrelations with "planning" and "positive reevaluation" strategies and an inverse one – with "fleeing" strategy. The subjective comfort of the Indonesian students had four interrelations with types of personality aссentuations: direct interrelations with hyperthymic and demonstrative aссentuations and an inverse one – with excitable and emotive. They had two interrelations with coping-strategies: inverse interrelations with "distancing" and "fleeing" strategies. The results proved the interdependence of subjective comfort and personal traits and the formed ways of mastering stress. The data obtained can be used in programs for coping-resource development in students.
Helmet, Shield, and Sword as Symbolic Signs of the Warrior Concept
Authors: Bodrikov Alexei B.
Published: July 2019

Attitude to Motherland plays an important role in Russian linguistic culture. The sphere is formed by a number of concepts, such as Fatherland, home, family, children, warrior, etc. The concept voin (warrior) has not been studied in modern linguistics, which adds relevance to the present research. Military concepts bear a large cultural load and make up an important component of the society. In Russian linguistic culture, a warrior is a defender, the one who protects the peace of the family, relatives, friends, and Motherland as a whole. Military concepts are just beginning to attract the attention of modern researchers. The present paper features the symbolic signs of the concept voin (warrior). The analysis is based on the constructions with the lexeme voin (warrior) from the Russian National Corps. One of the most common symbols of a warrior is weapon. The article focuses on the symbolic equipment signs of the concept, i.e. helmet, shield, and sword. The research employed conceptual, descriptive, and static analysis methods. The following symbolic stereotypical signs were especially frequent: helmet (24 %), armament (23.7 %), shield (22.8 %), and sword (10 %). The average degree of frequency was observed in such cognitive signs as chainmail (5.2 %), armor (4.7 %), spear (2.3 %), armor (2.1 %), and bow (1.6 %). Other signs demonstrated a low degree of frequency.
Emotional Concept "Ekel" (Disgust) and its Functional Properties in the Modern German Language
Authors: Korogodina Izabella V.
Published: July 2019

The present research reveals functional properties of emotional concept "Ekel" (disgust) and its linguistic representations in the modern German language. The emotion "disgust" can be defined as a basic emotion that introduces negative personal attitude to the fragments of reality. The mental representation of this emotion is an emotional concept with negative subjective assessments in its structure. The paper describes linguistic representations of disgust, defines its denomination, and outlines the paradigmatic relations of the lexeme Ekel and its linguistic contexts. The author believes that the emotion behind the lexeme "Ekel" fulfils three functions: biological, social, and protective. The biological function is aimed at removal of the object of disgust. The social function lies in the negative characterization of events and the actions of agents. The protective function is in the rejection of potentially dangerous fragments of reality.
The Pragmatics of Complimentary Speech Acts: Aspects of Regional Identity
Authors: Kurakina Natalia A.
Published: July 2019

The research on the pragmatics of complimentary speech acts should be carried out with due account for such social dimensions as gender, status-marked, age-related, and regional constituent parts. The aim of the study at hand is to elaborate on complimentary speech acts in the light of what will be termed as 'regional identity' within the framework of this article. Notwithstanding many studies of regional identity [1], few have revealed evident account of the representation of the interlocutor's regional identity in the language. This investigation concentrates on the theory of regional identity. The aim of the study is to consider the impact of the place where people live in on the production of complimentary speech acts in the British and American linguacultures. This scientific paper analyzes the significant features of compliments produced by people of urban-related identity and rural-related identity. Therefore, the paper focuses on answering the following research questions: What is the definition of complimentary speech act? What does regional identity mean? How is regional identity reflected in the compliments paid by the British and the Americans? Following the critical analysis of current works [1] on the theory of regional identity, this paper presents complimentary speech acts collected from English and American fiction of the XX and XXI centuries: Fowles J., Jardine Q., Salinger, Smith Z., Stockett K., Yates R., in the prospect of investigation the reflection of regional identity in language.
Argentina ¿bastión regional de la separación entre Seguridad y Defensa?
Authors: Calderón Emilse Eliana
Published: July 2019

En un contexto de debate sobre la separación entre la seguridad pública y la defensa nacional, el presente artículo tiene como objetivo responder al interrogante acerca de si Argentina continúa siendo un bastión regional en lo que respecta a la separación de tales ámbitos. Mediante un estudio cualitativo, desarrollado especialmente a través del análisis de fuentes primarias, el escrito examina los cursos de acción desplegados durante los gobiernos de Cristina Fernández de Kirchner y el mandato de Mauricio Macri en cuanto al combate del narcotráfico. Se argumenta que, desde una perspectiva fáctica, Argentina dejó de ser el bastión regional de la separación entre seguridad y defensa, dada la situación de erosión continua que impacta en la implementación del esquema normativo vigente.
Las cartas apócrifas de Salustio y la tradición clásica republicana
Authors: Martín Alvarado Helver
Published: July 2019

Se reconstruyen los planteamientos generales de la tradición clásica republicana y las causas históricas de crisis social y política que dieron origen a la reflexión sobre la constitución. Luego se examina su influencia al hilo de los hechos descritos por dos cartas apócrifas de Salustio a César, antes y después de que este se impusiera militarmente como dictador en Roma. La intención es revisar la construcción ideológica de la concordia civil para la res publica. Mediante tal análisis contextual y sus antecedentes teóricos, se arroja una nueva luz sobre el modo en que las cartas no solo dan forma a los tratados sobre el arte de gobernar, sino que conciben la posibilidad constitucional de una “monarquía republicana” para salvar el bien común ante los peligros de la guerra civil.
Implementasi Metode Inquiry Discovery untuk Pembentukan Kreativitas Mahasiswa dalam Seni Penyajian Makanan
Authors: Komariah Kokom
Published: July 2019

Kreativitas  dapat dikembangkan  melalui berbagai cara, sementara ini implementasi inquiry dan descovery  pada  praktek seni penyajian makanan  belum pernah dikaji.  Melalui tulisan ini ingin diketahui  apakah penggunaan metode inquiry. Discovery berdampak pada pembentukan kreativitas seni penyajian makanan. Penelitian ini dilakukan  melalui penelitian tindakan kelas, metode  penelitian dimodifikasi dari Kemmis, setiap siklus  dibagi 3 tahap yaitu perencanaan, observasi dan tindakan serta refleksi.  Subjek penelitian adalah  39 orang mahasiswa. Pengumpulan data melalui observasi, angket dan wawancara, Analisis data dilakukan secara deskiptif kuantitatif. Hasil penelitian    menemukan  metode  inquiry discovery  menunjukkan kreativitas  proses  sangat baik (3,44) dan kreativitas  produk  baik (3,97), dan  kreativitas  individu  secara  rerata sangat baik (3,33). Dengan demikian  proses inquiry  dapat membentuk  peserta didik  untuk  berkreasi  pada  aktivitas  seni penyajian makanan, hal ini dapat dibuktikan dengan  produk yang dihasilkan  lebih bervariasi tidak terpancang pada contoh yang diberikan oleh dosen, dan  gambar atau model yang di dapatkan melalui  internet.
Pengembangan Video Pembelajaran Mata Kuliah Pengujian Bahan Pangan Materi Sifat Telur
Authors: Anggraeni Andian Ari , Nugraheni Mutiara , Rinawati Wika
Published: July 2019

Tujuan penelitian ini: mengembangkan dan menilai kelayakan video pembelajaran mata kuliah Pengujian Bahan Pangan untuk materi telur oleh ahli materi, ahli media dan calon pengguna. Penelitian ini merupakan penelitian pengembangan. Pengembangan video pembelajaran dilakukan dengan pendekatan 4D (Define, Design, Develop dan Dissemination). Video pembelajaran ini menjelaskan sifat fisik dan emulsi telur. Metode pengumpulan data menggunakan angket penilaian kelayakan media. Uji coba terbatas video pembelajaran dilakukan pada 30 orang mahasiswa Pendidikan Teknik Boga, Universitas Negeri Yogyakarta. Hasil penelitian menunjukkan bahwa: 1) video pembelajaran mata kuliah Pengujian Bahan Pangan untuk materi sifat fisik dan emulsi telur telah dikembangkan dengan format mp4, durasi 11 menit, dan terdiri dari 5 bagian yaitu pembukaan, persiapan alat dan bahan, eksperimen, evaluasi hasil dan penutupan. Video diunggah dalam YouTube channel Pendidikan Teknik Boga Universitas Negeri Yogyakarta dengan URL https://youtu.be/l0b_F_2pAQU. 2) nilai kelayakan video pembelajaran berdasar ahli materi 96% kategori sangat layak, ahli media 88% sangat layak dan calon pengguna 83% sangat layak, sehingga video pembelajaran ini sangat layak digunakan sebagai media pembelajaran.
Tata Rias Fantasi Lionfish Lepu Dalam Pergelaran Drama Musikal Sabda Raja Mutiara
Authors: Novita Elok , Nadilah Shabrina
Published: July 2019

Penelitian  ini adaptasi dari penulisan proyek akhir mahasiswa D3 Tata Rias& Kecantikan yang menggelar acara drama musikal sabda raja mutiara. Adapun tujuan pembuatannya  untuk memperlihatkan proses hasil rias fantasi mulai dari merancangtata  rias fantasi, merancang  kostum dan kelengkapanya sampai aplikasi rias fantasi  dan menata kostum dengan kelengkapannya pada tokoh Lionfish Lepu dan mempergelarkan drama musikal Sabda Raja Mutiara yang terdapat tokoh Lionsfish Lepu. Metode yang digunakan untuk endapatkan hasil rias fantasi tokoh Lionfish Lepu menggunakan R&D dengan model pengembangan 4D, yaitu: 1) define; 2) design; 3) develop; 4) disseminate. Waktu penelitian dilakukan di lab tata rias dan kecantikan lt 2 program studi Tata Rias& Kecantikan , jurusan PTBB, FT-UNY. Hasil yang diperoleh dari proyek akhir ini, yaitu: 1) rancangan tata rias fantasi dan rancangan kostum serta kelengkapannya; 2) terwujudnya aplikasi tata rias fantasi berupa ; 3) terselenggara penampilan tokoh Lionfish Lepu dalam sebuah pergelaran di auditorium UNY 26 Januari 2017 pukul 13.00 wib yang dihadiri 850 penonton.
Pengembangan Video Pembelajaran Dodot Pengantin Puteri Gaya Solo Basahan
Authors: Juniastuti Eni , Yuswati Yuswati , Tritanti Asi
Published: July 2019

Tujuan dari penelitian ini adalah: 1) untuk mengembangkan naskah program video pembelajaran Dodot Pengantin Putri Gaya Solo Basahan, 2) untuk menguji kelayakan video pembelajaran Dodot Pengantin Putri Gaya Solo Basahan. Penelitian ini merupakan penelitian pengembangan (research and development). Subyek penelitian adalah mahasiswa semester 3 dan semester 5 prodi D3 Tata Rias dan kecantikan FT UNY tahun angkatan 2008 yang sudah mengambil Mata Kuliah Pengantin Indonesia II dan angkatan 2009 yang belum mengambil Mata Kuliah Pengantin Indonesia II. Data penelitian dianalisis dengan teknik deskriptif kuantitatif secara sederhana, yakni dengan membandingkan nilai rerata. Hasil penelitian menunjukkan bahwa: 1) Pengembangan Video Pembelajara Dodot pengantin gaya solo basahan terdiri dari beberapa tahapan antara lain: a)Terdapat perencanaan dalam merumuskan tujuan, disesuaikan dengan kebutuhan mahasiswa agar dapat tercapai kompetensi dibidang Tata Rias Pengantin.b) Pembuatan produk Video Pembelajara Dodot pengantin gaya Solo Basahan dengan prosedur yang direncanakan.c) Uji coba Video untuk memvalidasi produk, dengan validasi ahli materi,dan  ahli media yang berkompeten di bidang Tata Rias Pengantin Terutama penganti Gaya Solo Basahan . d) Merevisi hasil produk dan memperbaiki sebelum dilakukan uji coba dilapangan.e) Uji coba produk dilapangan atau pada pengguna produk tersebut.f) membuat laporan hasil sesuai dengan data yang diperoleh dilapangan baik dari ahli materi, ahli media dan pengguna Video Dodot pengantin gaya Solo Basahan 2) penelitian Video Pembelajaran Dodot Pengantin Putri Gaya Solo Basahan Puteri ini dalam kategori sangat layak sebagai sumber belajar menurut ahli media dan ahli materi, dan baik berdasarkan hasil uji coba di lapangan.
A importância do médico de atenção primária no rastreamento e diagnóstico precoce da doença renal crônica
Authors: Maciel de Oliveira Camila , Dos Santos Eli Basílio Alves , Bermude Beatriz Elizabeth Bagatin Veleda , Ferreira Lucille Ribeiro , Tizzot Edison Almeida , Mourão Júnior Carlos Alberto
Published: July 2019

A Doença Renal Crônica - definida como deterioração da função renal de forma persistente, gradual e progressiva (perda da capacidade de excretar água, concentrar urina e conservar eletrólitos) - é detectada comumente por medidas laboratoriais no sangue (creatinina) e urina (albumina). Esta é uma doença com múltiplas complicações, alta mortalidade, qualidade de vida comprometida e representa alto custo para o sistema de saúde um modo geral, tanto público quanto privado. Assim, sugere-se ter como foco a identificação dos vários estágios da doença e de seus fatores de risco, intervindo principalmente nos estágios precoces, em especial em pacientes de alto risco.
Perfil de pacientes e a ocorrência de complicações após cirurgia cardiovascular em hospital quaternário
Authors: Pereira Karen Thalita , Silva Bárbara Santucci da , Soares Naury de Jesus Danzi , Hueb Alexandre Ciappina
Published: July 2019

Introdução:As complicações no pós-operatório de cirurgia cardiovascular podem aumentar o tempo de internação, a taxa de mortalidade e os custos hospitalares. Objetivo: Conhecer as características dos pacientes submetidos à cirurgia cardiovascular e identificar as complicações ocorridas no pós-operatório, durante o tempo de internação, em hospital quaternário. Métodos: Estudo unicêntrico, retrospectivo, transversal e quantitativo. Foram analisados 90 prontuários de pacientes submetidos a cirurgia cardiovascular, de junho de 2014 a julho de 2017. Resultados: Maior prevalência de pacientes do sexo masculino (67,8%), média de idade de 63,8 ± 3,4 anos e hipertensos (90%). O procedimento mais realizado foi a revascularização do miocárdio e o óbito entre esses pacientes foi de 3,33%. A circulação extracorpórea foi utilizada em 78% das cirurgias. Maioria dos pacientes ficou internada por menos de 24 h até a realização do procedimento. No pós-operatório, o tempo de ventilação mecânica foi inferior a 24 h e a droga mais utilizada foi o cloridrato de dobutamina. A complicação arrítmica foi a mais comum, com frequência de 22%. Conclusão:Não foi possível observar associação entre a pre-sença de fatores de risco e a ocorrência de com-plicações intra-hospitalares nos pacientes em pós-operatório de cirurgia cardiovascular.
Епідуральне введення кортикостероїдів у лікуванні хронічного дискогенного болю в нижній частині спини
Authors: Smolanka V.I. , Fedurtsia V.M. , Pavlov B.B.
Published: July 2019

Актуальність. Біль у нижній частині спини залишається однією з найпоширеніших проблем хребетного стовпа та хронічних больових синдромів взагалі. Вона є частою причиною втрати працездатності, а витрати на неї вражають значністю сум. На сьогодні існують три напрямки лікування дискогенного болю — фізіотерапевтичний, медикаментозний і хірургічний. Інтервенційне лікування дискогенного болю шляхом уведення лікарських препаратів у епідуральний простір однаковою мірою можна віднести як до малоінвазивної хірургії, так і до активної таргетной терапії. Мета дослідження — вивчити динаміку больового синдрому в пацієнтів, які страждають від хронічного дискогенного болю в нижній частині спини, при використанні в їх лікуванні епідуральних стероїдних ін’єкцій. Матеріали та методи. У ретроспективне дослідження включено 74 пацієнти віком від 25 до 83 років (середній вік — 53,86 ± 14,27 року), пролікованих із 2015 по 2017 рік у клініці «Нейромед» м. Києва та Ужгородському обласному центрі нейрохірургії та неврології. У всіх досліджуваних після комплексного обстеження діагностовано терапевтично-резистентний хронічний дискогенний біль у нижній частині спини. Нами застосовувалося інтерламінарне та трансфорамінальне введення кортико­стероїдів під радіологічним контролем С-дуги. Всього було виконано 35 (47 %) трансфорамінальних епідуральних ін’єкцій, або блокад, і 39 інтерламінарних епідуральних блокад. За локалізацією проведені маніпуляції було розподілено наступним чином: на рівні L5-S1 — 36 (48 %), на рівні L4-L5 — 17 (23 %), на рівні L3-L4 — 12 (16 %) і на рівні L2-L3 — 9 (12 %). Больовий синдром оцінювався за 10-бальною візуально-аналоговою шкалою (ВАШ) перед маніпуляцією, через 7 і 30 днів після її проведення. Результати. Ускладнень не зареєстровано. Абсолютно всі пацієнти відзначали зниження больового синдрому. Більшість пацієнтів до маніпуляції характеризували свій біль як «дуже сильний, на межі з нестерпним» (7,01 ± 0,86 за ВАШ), а через тиждень після процедури більшість вже описували больові відчуття як «легкі, часом помірні» (3,68 ± 0,87 за ВАШ). Така тенденція зберігалася і через місяць після маніпуляції (1,98 ± 1,01 за ВАШ). Висновки. Епідуральне уведення кортикостероїдів є безпечним і ефективним способом лікування хронічного болю в нижній частині спини. Ця інтервенційна методика дозволяє істотно знизити інтенсивність страждання.
Investigation of antiscalant dosing influence on scaling process in reverse osmosis facilities and membrane surface adsorption
Authors: Frenkel Val S. , Pervov Alexey G. , Andrianov Alexey P. , Golovesov Vladimir A.
Published: July 2019

Introduction. Understanding of crystal growth mechanism enables to develop efficient tools to control scaling and improve the process of treatment using membranes and increasing the amount of filtrate output. This investigation is aimed at studying an antiscalant behaviour in reverse osmosis (RO) process when treating ground water. Experimental dependences of calcium carbonate scaling efficiency on antiscalant dosage were found. Rates of adsorption on crystal surface of scaling deposit and on membrane surfaces were compared. Dependences of rates of inhibitor adsorption on crystal surface versus scaling rates were determined. Inhibitor adsorption on RO membrane surfaces was studied. New approaches to studying crystal growth mechanism in the presence of polymeric inhibitors are presented.

Materials and methods. In the course of experiments conducted with using inhibitor dissolved in distilled water, inhibitor sorption on membrane surface was observed in the absence of calcium ions. As to experiments with dosing the inhibitor in tap water, the inhibitor sorption on the membrane did not occur: the inhibitor was adsorbed on the surface of the scaling crystals.

Results. Experimental relationships are obtained that show dependencies of calcium carbonate deposit growth rates versus RO facility filtrate output values in the presence of different antiscalants with their dose values of 3, 5 and 7 mg/l. The article shows that antiscalant dose value does not provide substantial influence on antiscalant efficiency when natural water with low hardness is treated in the RO facility. This permits substantial reduction of operational costs. It was also proved that inhibitor is not adsorbed on membrane surface during natural water treatment that also confirms efficiency of low antiscalant dosing.

Conclusions. Low hardness values of natural water (3–5 mill equivalents per liter) demonstrate that antiscalant efficiencies do not depend on its dose. Rate of inhibitor adsorption on crystal surface during calcium carbonate deposition also increases with scaling rate increase. Rates of antiscalant consumption increase with antiscalant dose values. In natural water the dissolved antiscalant molecules are bonded with calcium ions therefore antiscalant does not react with membranes and is not adsorbed on membrane surface.
NEW INFORMATION TECHNOLOGIES FOR ANALYSIS SKELETON PLANAR SCINTIGRAMMS OF PATIENTS WITH BREAST CANCER
Authors: Kang Xinmei , Kosykh N. E. , Levkova E. A. , Razuvaev V. A. , Savin S. Z.
Published: July 2019

In work is described practical approach to the expert system building for the analysis skeleton planar scintigramms. The aim is to analyze the numerical characteristics of bone metastases by scintigraphy. Objective. Progress in the development of bioinformatics and mathematical methods in biomedicine, as well as the development of computer and telecommunications systems and networks determines the look of the present and future of oncology technology and of medicine in general. At last years of one of the directions of high-tech-medicine development is a processing the digital image: improvement of quality of image, recovering image, its recognition of separate elements. Recognition of pathological processes is one of the most important problems of processing the medical image. Methods and results. Method of computer-aided analysis of planar osteostsintigrammy studied the skeleton of patients with breast cancer are in complete remission and in the phase progression of the disease with metastases to the skeleton. As analyzed parameter was used brightness of images. The study of the physiological accumulation of radiopharmaceuticals in patients without metastasis to the skeleton indicates a wide variation in the brightness values of the scintigram in some areas of the skeleton. At the same anatomical areas of the skeleton there are significant differences in the values of the index of average brightness. In almost all areas of the skeleton averages of the brightness lesions hyperfixation RFP for scintigram significantly prevail over those of «physiological» lesions hyperfixation. Thus, there is a direct relationship between the levels of accumulation of the radiopharmaceutical in areas of the skeleton without metastatic lesion and bone metastases occurring in these zones. Consider methodological approaches to studies of quality of qualifier at the expert system building for the analysis skeleton planar scintigramms, as well as results of conducting calculations.
THE EFFECTIVENES OF COMPLEX DRUG “BIFIDUM BAG” FOR STATUS CORRECTION OF LARGE INTESTINE MICROBOICENOSIS AND ANTIOXIDANT PROPERTIES OF COLONOCYTES IN EXPERIMENTAL DYSBIOSIS
Authors: Medvedeva O. A. , Korolev V. A. , Verevkina N. A. , Riadnova V. A.
Published: July 2019

The effectiveness of complex drug “Bifidum BAG” for status correction of large intestine microbiocenosis and antioxidant properties of colonocytes in experimental dysbiosis has been studied. Acomplex drug was administered to experimental animals, which includes Bifidobacterium and Dihydroquercetin. Quantitative and qualitative study of large intestine was done in mices by bacteriological method. The state of lipid peroxidation system was evaluatedaccoding to the content of acylhydroperoxide and malonic dialdehyde. The state of antioxidant protective system was reached by means of catalase and superoxide dismutase activity. Experimental dysbiosis was shown as significant changes in mucosal microflora, changes colonocytes antioxidant properties. The use of the complex preparation “Bifidum BAG”, led to the normalization of the colon microbiota (11 of 16 microorganisms were recovered). After correction gentamicin-associated dysbiosis with a complex probiotic, a positive effect of the drug on the colonocytes antioxidant defense was noted. So the activity of catalase increased 1.1 times, compared with the determined index in the group “dysbiosis”. The activity of superoxide dismutase increased 2 times in comparison with the group “dysbiosis”, exceeding the value of the control group. The concentration of LPO products in colonocytes of experimental animals decreased significantly. The content of malonicdialdehyde and acylhydroperoxide decreased 1.6 times and 5.6 times in comparison with the determined index of the group “dysbiosis”, respectively.
Psychosocial Status of Patients with Chronic Heart Failure Awaiting Heart Transplantation
Authors: Shindrikov Roman Yu. , Shchelkova Olga Yu. , Demchenko Elena A. , Sitnikova Mariya Yu.
Published: July 2019

A pilot study of psychosocial status of 80 patients (85% males) with terminal chronic heart failure (CHF), during the preparation for heart transplantation (HT) has been carried out in the Almazov National Medical Research Centre. The correlation of psychological, medical, biological and socio-demographic characteristics of patients as well as the dynamics of patients’ emotional state (anxiety and depression) during a long cardiology hospital stay (4 measurements over half a year) has been studied. The authors’ structured interview and a set of psychodiagnostic methods (“Index of General Well-being”, “Brief neuropsychological examination of cognitive sphere”, depression scale (SDS), scale of anxiety (STAI), personality questionnaire BIG-V) have been used in the study. For mathematical and statistical data processing the following methods included in the software package SPSS v. 20.0 have been used: the Pearson’s chi-squared test (χ2), the Mann - Whitney U test, the Spearman and Pearson correlations, and ANOVA. The results revealed the absence of clinically significant signs of depression, cognitive impairment, personality and system of significant relationships in the majority of patients at the first stage of the study (upon admission into hospital). The exception was the increased level of situational anxiety (M ± m = 43.2 ± 7.1). The study of the dynamics of the emotional state of patients reflected a systematic increase in the average group indices of the depression scale (upon admission M ± m = 46.9 ± 6.7; after 2 months M ± m = 48.9 ± 7.4; after 4 months M ± m = 51.1 ± 7.6; after 6 months M ± m = = 52.6 ± 7.5), as well as a decrease in the level of situational anxiety at the second stage of the study compared with the first and a further increase starting from the second period: after 2, 4, 6 months of the stay in hospital, respectively: M ± m = 41.3 ± 5.2; M ± m = 46.7 ± 6.8; M ± m = 50.8 ± 7.9). It was revealed that the level of situational anxiety at the second (F = 6.18; p < 0.05) and the third (F = 4.11; p < 0.05) stages of treatment is significantly higher in the patients after myocardial infarction(s). Also, the level of situational anxiety is higher at the first (F = 4.00; p < 0.05) and third (F = 3.68; p < 0.05) stages of hospitalization of the patients who have rare meetings with relatives as compared to the patients who are often visited by their relatives. The results reflect the psychosocial potential of patients waiting for HT, and may have a prognostic significance in relation to adherence to treatment in the postoperative period, which, in turn, largely determines the survival of patients.
How Psi Chi Became the International Honor Society in Psychology
Authors: Davis John M.
Published: July 2019

Psi Chi, the National Honor Society in Psychology, was founded in 1929 during the Ninth International Congress of Psychology at Yale University, the first convened in the United States. Eighty years later, in 2009, Psi Chi officially became the International Honor Society in Psychology. Now, on the tenth anniversary of that change, it seems fitting to tell the story of how Psi Chi became the International Honor Society in Psychology. Several former leaders contributed significantly to this international expansion. My involvement began when I was elected to the position of Vice-President for the Southwestern Region. During my two terms as VP, I advocated for an international perspective whenever possible. After completing my second term as VP, I was elected to the position of PresidentElect and began writing short articles for Eye on Psi Chi that suggested a more international perspective. As President, I continued the effort to encourage Psi Chi to become international. I developed ten proposed amendments to the Psi Chi Constitution that, if approved, would transition Psi Chi from a national to an international society. During the last business meeting of my term as Past-President in August 2008, the Council approved all ten amendments. The final step, a national vote by the Psi Chi chapters in April of 2009, also approved all ten amendments and made the changes official. Now, in 2019, Psi Chi celebrates the tenth anniversary of the transition from a national to an international society with 23 chapters in 15 countries or U.S. territories.
Transforming Psi Chi and Psychology Through Internationalization
Authors: Domenech Rodríguez Melanie M.
Published: July 2019

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The How and Why of Creating the First Psi Chi Video
Authors: Karlin Nancy J.
Published: July 2019

In 1998, Psi Chi produced its first video, under the guidance of Vice President Nancy Karlin. This nine-minute video offers detailed information featuring leading psychologists like Albert Bandura, Michael Wertheimer. Here, Dr. Karlin describes the back-story on how she crafted this stillunique video, which has been translated into Russian and is often used for chapter induction ceremonies the past 20 years. In English: https://www.youtube.com/watch?v=a8Y8m2qxhS4 In Russian: https://www.youtube.com/watch?v=1t63fKZ1OPY
Penyelesaian Sengketa Perkebunan Antara Perusahaan Perkebunan Sawit PT. Asiatic Persada dengan Suku Anak Dalam Batin IX di Desa Bungku Kecamatan Bajubang Kabupaten Batanghari
Authors: Fitria Fitria
Published: July 2019

Penelitian ini bertujuan untuk mengetahui dan menganalisis Mekanisme penyelesaian sengketa perkebunan antara perusahaan perkebunan sawit PT. Asiatic Persada dengan Suku Anak Anak Dalam Batin 9 Desa Bungku dan mengetahui dan meganalisis Perananan Pemerintah Daerah terhadap penyelesaian sengketa perkebunan antara perusahaan perkebunan sawit PT. Asiatic Persada dengan Suku Anak Anak Dalam Batin 9 Desa Bungku. Pendekatan yang digunakan bersifat yuridis empiris, secara yuridis melihat peraturan perundang-undangan yang mengatur tentang Penyelesaian  sengketa Perkebunan Antara Perusahaan Perkebunan Sawit PT. Asiatic Persada dengan Suku Anak Dalam Batin 9 Di Desa  Bungku  Kecamatan Bajubang Kabupaten Batanghari. Penelitian ini diharapkan bahwa Sengketa yang terjadi diantara Suku Anak Dalam dengan PT.Asiatic dan latar belakang kasus yang terjadi adalah sengketa pertanahan dan perkampungan masyarakat Suku Anak Dalam (SAD) Kelompok 113 tiga dusun (Tanah Menang, Pinang Tinggi, Padang Salak) yang berada di areal HGU  sebuah perusahaan kelapa  sawit yang belum dibebaskan. Akan tetapi, hingga saat ini, kesepakatan tersebut belum dilaksanakan oleh pihak perusahaan.
Model Pengelolaan Pertambangan Batubara Berbasis Penguatan Kelembagaan Masyarakat Adat di Kabupaten Bungo
Authors: Syarif Afif
Published: July 2019

Pertambangan batubara sebagai kekayaan alam yang tak terbarukan, pengelolaannya harus dilakukan seoptimal mungkin, efesien, transparan, berkelanjutan dan bewawasan lingkungan, serta berkeadilan agar memperoleh manfaat sebesar-besarnya kemakmuran rakyat secara berkelanjutan. Untuk itu kepastian hukum pengelolaan pertambangan batubara dapat memberikan kontribusi dalam mewujudkan keadilan bidang pertambangan batubara di Kabupaten Bungo.  Desain yang akan dilakukan dalam penelitian ini adalah menggunakan metode penelitian hukum normatif dengan pendekatan deskriptif analitis yang bertujuan untuk : (1) mencari konsep dan/atau model pengelolaan pertambangan batubara berbasis penguatan kelembagaan masyarakat adat dan hak-asasi manusia atas lingkungan hidup; (2) mengkaji konsep keadilan terhadap pengelolaan pertambangan batubara sebagai sumber daya alam; serta (3) melihat kewenangan pemerintah daerah terhadap pengelolaan pertambangan batubara di kabupaten Bungo. Untuk itu perlu dikaji model pengelolaan pertambangan batubara yang dapat memberikan konstribusi kongkrit dalam rangka terciptanya pembangunan berkelanjutan yang berkeadilan terhadap sumber daya alam batubara di Kabupaten Bungo.