bluuebunny/crossref_metadata_2025 huggingface dataset:
Brain-Protective Mechanisms of Transcription Factor NRF2: Toward a Common Strategy for Neurodegenerative Diseases
Authors: Cuadrado Antonio
Published: October 2021

Neurodegenerative diseases are characterized by the loss of homeostatic functions that control redox and energy metabolism, neuroinflammation, and proteostasis. The transcription factor nuclear factor erythroid 2–related factor 2 (NRF2) is a master controller of these functions, and its overall activity is compromised during aging and in these diseases. However, NRF2 can be activated pharmacologically and is now being considered a common therapeutic target. Many gaps still exist in our knowledge of the specific role that NRF2 plays in specialized brain cell functions or how these cells respond to the hallmarks of these diseases. This review discusses the relevance of NRF2 to several hallmark features of neurodegenerative diseases and the current status of pharmacological activators that might pass through the blood-brain barrier and provide a disease-modifying effect.
The Diverse Physiological Functions of Mechanically Activated Ion Channels in Mammals
Authors: Poole Kate
Published: October 2021

Many aspects of mammalian physiology are mechanically regulated. One set of molecules that can mediate mechanotransduction are the mechanically activated ion channels. These ionotropic force sensors are directly activated by mechanical inputs, resulting in ionic flux across the plasma membrane. While there has been much research focus on the role of mechanically activated ion channels in touch sensation and hearing, recent data have highlighted the broad expression pattern of these molecules in mammalian cells. Disruption of mechanically activated channels has been shown to impact ( a) the development of mechanoresponsive structures, ( b) acute mechanical sensing, and ( c) mechanically driven homeostatic maintenance in multiple tissue types. The diversity of processes impacted by these molecules highlights the importance of mechanically activated ion channels in mammalian physiology.
Somatic Mosaicism in Biology and Disease
Authors: Ogawa Hayato , Horitani Keita , Izumiya Yasuhiro , Sano Soichi
Published: October 2021

Contrary to earlier beliefs, every cell in the individual is genetically different due to somatic mutations. Consequently, tissues become a mixture of cells with distinct genomes, a phenomenon termed somatic mosaicism. Recent advances in genome sequencing technology have unveiled possible causes of mutations and how they shape the unique mutational landscape of the tissues. Moreover, the analysis of sequencing data in combination with clinical information has revealed the impacts of somatic mosaicism on disease processes. In this review, we discuss somatic mosaicism in various tissues and its clinical implications for human disease.
Optimization and Matching Scheme of Public Management Resources for Industry 4.0 and Smart City
Authors: Fan Jinglin , Shi Lei
Published: October 2021

With the development of Big Data, Industry 4.0, and other technologies, the concept of smart city has become a new goal, new concept, and new practice of many urban developments. It provides a method to solve the problem that public management cannot optimize resources in China’s urban development and puts forward a supporting scheme more in line with the optimization of public management resources. Effective use of relevant supporting schemes can improve urban public management capacity, optimize resources, and promote the city to embark on the road of scientific development. This paper starts with the multiobjective optimization algorithm to optimize the matching of public resources and realize the effective utilization of public management resources. Using particle swarm optimization algorithm, the optimal allocation management of 8 kinds of resources in this paper is carried out, and the optimization analysis is carried out from the performance indexes, such as resource allocation time and configuration complexity. Finally, the weights of the eight resources in importance, complexity, and resource demand are 0.4, 0.4, and 0.2, respectively. The proposed method realizes the classification of resources and the optimal matching of resources.
The Critical Role of Oxidative Stress in Sarcopenic Obesity
Authors: Gonzalez Andrea , Simon Felipe , Achiardi Oscar , Vilos Cristian , Cabrera Daniel , Cabello-Verrugio Claudio
Published: October 2021

Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function. SO relates to metabolic syndrome and an increased risk of morbimortality. The prevalence of SO varies because of lacking consensus criteria regarding its definition and the methodological difficulty in diagnosing sarcopenia and obesity. SO includes systemic alterations such as insulin resistance, increased proinflammatory cytokines, age‐associated hormonal changes, and decreased physical activity at pathophysiological levels. Interestingly, these alterations are influenced by oxidative stress, which is a critical factor in altering muscle function and the generation of metabolic dysfunctions. Thus, oxidative stress in SO alters muscle mass, the signaling pathways that control it, satellite cell functions, and mitochondrial and endoplasmic reticulum activities. Considering this background, our objectives in this review are to describe SO as a highly prevalent condition and look at the role of oxidative stress in SO pathophysiology.
[Retracted] Data Research on Tobacco Leaf Image Collection Based on Computer Vision Sensor
Authors: Su Huadong
Published: October 2021

In the process of tobacco silk making, how to better improve the quality of stem and leaf separation has become an issue of concern. His research mainly discusses the data collected from tobacco leaf images based on computer vision sensors. In LM (Levenberg‐Marquarelt) as a training function, the algorithm uses threshing effect samples for training and learning. This paper is aimed at extracting the shape characteristic parameters of tobacco leaves and obtains the shape parameters of the length, width, area, circumference, and roundness of the tobacco leaves. In this paper, boundary tracking is used to obtain the coordinate and direction information of the tobacco leaf boundary pixels in the image, which provides a basis for obtaining the subsequent extraction of tobacco leaf characteristic parameters. In the tobacco leaf grading system, the tobacco leaf feature parameter extraction module displays the geometric characteristics of tobacco leaf, such as length, width, area, aspect ratio, rectangularity, and color characteristic, hue H, saturation S, A channel, and B channel in detail through the computer vision sensor. Finally, the subjective and objective combination weighting method is used to combine and weight the indicators of the threshing effect of the first‐level threshing machine, which not only considers the quantity of information provided by the indicators but also takes into account the subjective view of the experts, which increases the weight of the indicators, accuracy, and scientificity. The approximation accuracy of the training samples of the threshing effect prediction model based on the BP neural network LM algorithm is 99.495%, the approximation accuracy of the validation set is 96.535%, and the approximation accuracy of the test set is 98.392%. This research will greatly improve production efficiency and meet the enterprise’s requirements for high efficiency and low cost.
The First 24 h Hemodynamic Management in NICU after Revascularization Surgery in Moyamoya Disease
Authors: Song Jie , Lei Yu , Chen Long , Gao Chao , Ni Wei , Wu Xing , Wu Gang , Mao Ying , Hu Jin , Gu Yuxiang
Published: October 2021

Objective. To evaluate whether hemodynamic factors are risk factors for prognosis in moyamoya disease (MMD). Materials and Methods. The retrospective study reviewed a single-center MMD cohort in Huashan Hospital from August 2017 to January 2020. Stroke events in 30 days and follow-up modified Rankin Scale (mRS) grade were recorded. Systematic assessments with perioperative mean arterial pressure (MAP), red blood cell (RBC) parameters, and fluid management were also conducted. Logistic regressions were applied to evaluate the predictors of worse outcomes. Data was analyzed using SPSS 24.0. Results. Admission to neurological intensive care unit (NICU) totalled about 347 after revascularization surgery. The result showed that the higher the postoperative MAP level (favorable group

95.7
±
11.4

 mmHg vs. unfavorable group

103.6
±
10.4

 mmHg,

p
<
0.001

) and the greater the MAP variability (favorable group

0.26
±
13.2

vs. unfavorable group

7.2
±
13.5

,

p
=
0.006

) were, the higher the patient’s follow-up mRS grade was. What is more, a higher early postoperative Hb level also seemed to predict a worse long-term clinical outcome (favorable group

116.9
±
17.1

 g/L vs. unfavorable group

123.7
±
13.0

 g/L,

p
=
0.03

), but the difference disappeared after adjusting sex and age. Logistic regression analyses showed that a higher level of postoperative MAP (

β
=
0.024

, 95% CI (0.004, 0.044), and

p
=
0.02

) within the first 24 h in NICU might be the short-term risk factor. For long-term outcome, a higher level (

β
=
1.058

, 95% CI (1.022, 1.096), and

p
=
0.001

) and a greater variability (

β
=
30.982

, 95% CI (2.112, 454.414), and

p
=
0.01

) of postoperative MAP might be the negative predictors of mRS grade. Conclusions. The early postoperative hemodynamic management might be extremely critical for patients with MMD. Both high postoperative MAP levels and large MAP variability might affect the prognosis. What is more, we also found that a higher postoperative Hb level might be related with a worse outcome.
Development of Coriandrum sativum Oil Nanoemulgel and Evaluation of Its Antimicrobial and Anticancer Activity
Authors: Eid Ahmad M. , Issa Linda , Al-kharouf Omamah , Jaber Raghad , Hreash Fatima
Published: October 2021

This study is aimed at developing coriander oil into a nanoemulgel and evaluating its antimicrobial and anticancer effects. Coriander (Coriandrum sativum) oil was developed into a nanoemulgel by using a self‐nanoemulsifying technique with Tween 80 and Span 80. Hydrogel material (Carbopol 940) was then incorporated into the nanoemulsion and mixed well. After this, we evaluated the particle size, polydispersity index (PDI), rheology, antimicrobial effect, and cytotoxic activity. The nanoemulsion had a PDI of 0.188 and a particle size of 165.72 nm. Interesting results were obtained with the nanoemulgel against different types of bacteria, such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and methicillin‐resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 2.3 μg/ml, 3.75 μg/ml, and 6.5 μg/ml, respectively. In addition, the half‐maximal inhibitory concentration (IC50) of the nanoemulgel when applying it to human breast cancer cells (MCF‐7), hepatocellular carcinoma cells (Hep3B), and human cervical epithelioid carcinoma cells (HeLa) was 28.84 μg/ml, 28.18 μg/ml, and 24.54 μg/ml, respectively, which proves that the nanoemulgel has anticancer effects. The development of C. sativum oil into a nanoemulgel by using a self‐nanoemulsifying technique showed a bioactive property better than that in crude oil. Therefore, simple nanotechnology techniques are a promising step in the preparation of pharmaceutical dosage forms.
An Analytical Solution for the Interaction of Waves with Arrays of Circular Cylinders
Authors: Mi Zhao , Pengzhen Long , Piguang Wang , Chao Zhang , Xiuli Du
Published: October 2021

This paper presents an analytical method to investigate the multiple scattering problem within arrays of vertical bottom-mounted circular cylinders subjected to linear incident waves. Based on the Laplace equation and boundary conditions on the seabed and surface, a formulation of a two-dimensional multiple scattering problem is first obtained by using the variable separation method. Furthermore, the analytical solution of the wave forces on multiple circular cylinders is derived, which consists of the incident wave force due to the linear incident wave and the scattered wave forces considering multiple scattering waves. The presented analytical solution is validated by comparing its results with a numerical method, and the result shows that the analytical solution is in good agreement with the numerical one. Finally, the multiple scattering analysis is conducted on arrays of cylinders with different incident wave numbers, distances between cylinders, and quantities.
Fuzzy Comprehensive Evaluation Model of M&A Synergy Based on Transfer Learning Graph Neural Network
Authors: Zhu Mingxun , Meng Zhigang
Published: October 2021

With the rapid development of modern China and the influx of capital, the number of companies has gradually increased. However, most companies cannot operate for a long time due to various reasons. Therefore, mergers and acquisitions have occurred. Large companies merge small companies to some extent. The number of employees can be guaranteed, and the market can be stabilized. However, mergers and acquisitions also have higher risks. As the pace of mergers and acquisitions accelerates, there are more and more cases of failed mergers and acquisitions. The synergy effect of mergers and acquisitions is an important indicator to judge the performance of mergers and acquisitions. This article measures the synergy obtained by the main enterprise from the perspective of performance changes, establishes an evaluation model through the rate of change of financial indicators and migration learning, estimates it through a neural network model, and conducts an empirical analysis on it. The transfer learning neural network has been studied in depth. The research of this article is to accurately assess the synergy effect obtained after mergers and acquisitions and to analyze whether the company can profit from mergers and acquisitions, so as to provide a reference for subsequent mergers and acquisitions between companies.
Levels of Serum sST2, MMP-3, and Gal-3 in Patients with Essential Hypertension and Their Correlation with Left Ventricular Hypertrophy
Authors: Wang Xueling , Han Wei , Han Lin , Yang Jiyuan , Li Kehui , Fan Yun
Published: October 2021

Essential hypertension (EH) is a clinically frequent cardiovascular disease, with insidious onset, causing increased pressure load and neuroregulation disorders in patients. Long-term EH can cause left ventricular hypertrophy (LVH), which can lead to arrhythmia and even death. The soluble suppression of tumorigenicity 2 (sST2), matrix metalloproteinase-3 (MMP-3), and galectin-3 (Gal-3) in serum plays an important role in the occurrence, development, and prognosis of cardiovascular diseases. In our study, we divided EH patients into 3 levels and groups with or without LVH, according to their condition. The levels of sST2, MMP-3, and Gal-3 in the serum were measured in different groups of patients. Our results showed that the levels of sST2, MMP-3, and Gal-3 in the serum increased progressively with the level in different EH groups. The levels of sST2, MMP-3, and Gal-3 in the serum of the LVH group were higher than those of the NLVH group, and it is positively correlated with LVH-related indexes. The risk of developing and progressing to LVH in patients with EH can be determined by the method of measuring three indicators.
Research on Interactive Art Online Teaching System Based on BS Mode and Internet of Things
Authors: Ying Yang , Hongyan Wang
Published: October 2021

Traditional online art teaching system has problems such as poor score improvement and low system throughput. Therefore, this paper designs an interactive online art teaching system based on BS mode and IoT. Design the overall structure of the art teaching system according to THE B/S structure, build the interactive art online teaching model according to the system role use cases, introduce the RFID technology in the Internet of Things to control the information transmission of the interactive art online teaching system, and complete the code development of interactive art online teaching function. Complete the interactive art online teaching system based on BS mode and the Internet of Things. The experimental results show that the designed system can improve the scores of students in art colleges and improve the throughput of the system.
Mathematical Analysis of a Fractional‐Order Predator‐Prey Network with Feedback Control Strategy
Authors: Zhang Wei , Fei Yu , Li Zhouhong , Huang Chengdai
Published: October 2021

This paper examines the bifurcation control problem of a class of delayed fractional‐order predator‐prey models in accordance with an enhancing feedback controller. Firstly, the bifurcation points of the devised model are precisely figured out via theoretical derivation taking time delay as a bifurcation parameter. Secondly, a set comparative analysis on the influence of bifurcation control is numerically studied containing enhancing feedback, dislocated feedback, and eliminating feedback approaches. It can be seen that the stability performance of the proposed model can be immensely heightened by the enhancing feedback approach. At the end, a numerical example is given to illustrate the feasibility of the theoretical results.
Research on Hysteretic Models for Prestressed and Non‐Prestressed Steel Reinforced Concrete Frames
Authors: Luo Huihui , Wang Kun
Published: October 2021

The beam‐column fibre model is used to simulate the entire hysteretic process of the prestressed and non‐prestressed steel reinforced concrete frame, and the results are compared with the test results. Based on the analysis of a large number of parameters, the hysteretic curve characteristics of this kind of composite frame are discussed, and the load‐displacement hysteretic models of single‐storey and single‐span composite frame are established. The models can comprehensively consider the influence of axial compression ratio and column slenderness ratio and can predict the hysteretic behaviour of this kind of composite frame under horizontal loads. The load‐displacement hysteretic models are consistent with the numerical simulation results. Relevant research can provide reference for simplifying the elastic‐plastic dynamic analysis of structures.
Composite Score of Healthy Lifestyle Factors and the Risk of Pancreatic Cancer in a Prospective Cohort Study
Authors: Luu Hung N. , Paragomi Pedram , Wang Renwei , Jin Aizhen , Brand Randall E. , Koh Woon-Puay , Yuan Jian-Min
Published: October 2021

While the associations between individual lifestyle factors and risk of pancreatic cancer were studied extensively, their combined impact has not been examined. We evaluated the association of a composite score of healthy lifestyle factors, including body mass index, cigarette smoking, the Alternative Healthy Eating Index-2010 (AHEI-2010), sleep duration, and physical activity with pancreatic cancer risk in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63,257 Chinese aged 45 to 74 years at enrollment in 1993 to 1998 with up to 25 years of follow up. Cox proportional hazard regression method was used to estimate HR and its 95% confidence interval (CI) with adjustment for multiple potential confounders. We identified 316 incident pancreatic cancer cases among the cohort participants after a mean 17 years of follow up. Individuals with higher composite scores representing healthier lifestyle were at significantly lower risk of pancreatic cancer. The multivariate-adjusted HRs (95% CIs) of pancreatic cancer incidence for the composite scores 2, 3, 4, 5, 6 to 7 were 0.60 (0.50–0.91), 0.48 (0.32–0.71), 0.45 (0.31–0.67), 0.41 (0.27–0.62), and 0.38 (0.24–0.62), respectively, compared with the scores 0 to 1 (Ptrend < 0.0001). The inverse association was more apparent among participants without diabetes history and was robust in men and women as well as in alcohol drinkers and nondrinkers. In summary, the association for pancreatic cancer risk was stronger for the aggregated than individual healthy lifestyle factors. These findings suggest that a more comprehensive lifestyle modification strategy would be more effective for prevention of pancreatic cancer than the change of a single lifestyle factor.

Prevention Relevance:

In this large prospective Asian study, we calculated a composite score of healthy lifestyle factors, including body mass index, cigarette smoking, the Alternative Healthy Eating Index-2010 (AHEI-2010), sleep duration, and physical activity and found this composite score was associated with a significant reduction in pancreatic cancer risk, by as much as 62%. This finding suggests that public health programs emphasizing comprehensive lifestyle modification strategy would be more effective for prevention of pancreatic cancer than the change of a single lifestyle factor.
Juzentaihoto Exerts Anti-Allergic Effects by Inhibiting Effector T-Cell Activation and Inducing and/or Activating Regulatory T Cells in a Murine Model of Contact Hypersensitivity
Authors: Tsuge Atsushi , Yonekura Sho , Watanabe Satomi , Kurosaki Yuta , Hisaka Shinsuke , Nose Mitsuhiko
Published: October 2021

Background: Juzentaihoto (JTT) is a Kampo prescription that has been used clinically for treating skin diseases such as atopic dermatitis in Japan. We have previously studied the anti-allergic effects of JTT on 2,4,6-trinitrochlorobenzene (TNCB)-induced contact hypersensitivity (CHS) in mice and demonstrated that it significantly suppresses ear swelling in a dose-dependent manner. However, the mechanism underlying the anti-allergic actions of JTT is obscure. Methods: We investigated the mechanism underlying the anti-allergic effects of JTT using a TNCB-induced murine CHS model and adoptive cell transfer experiments. Results: We showed that the anti-allergic effects of JTT are due to inhibition of effector T-cell activation and induction and/or activation of regulatory T cells. Furthermore, ex vivo experiments confirmed the effect of JTT on the activation of effector T cells and regulatory T cells, as interferon-γ production decreased, whereas interleukin (IL)-10 production increased, in the cultured lymphocytes obtained from 5% TNCB-sensitized mice treated with anti-CD3ε and anti-CD28 monoclonal antibodies. Flow cytometry showed that the CD4+CD25+Foxp3+, CD4+CD25+Foxp3−, and CD8+CD122+ cell population increased after oral administration of JTT. Finally, the anti-allergic effect of JTT by inducing and/or activating regulatory T cells (Tregs) was confirmed to be mediated by IL-10 through in vivo neutralization experiments with anti-IL-10 monoclonal antibodies. Conclusion: We suggested that JTT exerts anti-allergic effects by regulating the activation of effector T cells and Tregs involved in murine CHS model.
Clinical-Diffusion Mismatch Is Associated with Early Neurological Improvement after Late-Window Endovascular Treatment
Authors: Kim Bum Joon , Lee Yoojin , Kwon Boseong , Chang Jun Young , Song Yun Sun , Lee Deok Hee , Kwon Sun U. , Kim Jong S. , Kang Dong-Wha
Published: October 2021

Background: Clinical-diffusion mismatch (CDM) and perfusion-diffusion mismatch (PDM) are used to select patients for endovascular thrombectomy (EVT) in the late-window period. As CDM well reflects true penumbra, we hypothesized that patients with CDM and PDM would respond better to EVT than those with PDM only at the late-window period. Methods: Acute ischemic stroke patients who received EVT 6–24 h after stroke onset were included. PDM (perfusion-/diffusion-weighted image (DWI) lesion volume >1.8) was used to select candidates for EVT in this time-period in our center. CDM was defined according to the DAWN trial criteria. Response to EVT was compared between patients with and without CDM. Early neurological improvement (ENI) was defined as improvement >4 points on National Institutes of Health Stroke Scale (NIHSS) score 1 day after EVT. Multivariable analysis was performed to investigate independent factors associated with ENI. The correlation between DWI lesion volume and NIHSS score was investigated in those with and without CDM. Results: Among 94 patients enrolled, all patients had PDM and 44 (46.3%) had CDM. Forty-eight patients (51.1%) showed ENI. The prevalence of hypertension, initial NIHSS score, improvement in NIHSS score after EVT, and prevalence of ENI were greater in patients with CDM than those without. ENI was independently associated with onset-to-door time (odds ratio [95% confidence interval]: 0.998 [0.997–1.000]; p = 0.042), complete recanalization (23.912 [2.238–255.489]; p = 0.009), initial NIHSS score (1.180 [1.012–1.377]; p = 0.034), and the presence of CDM (5.160 [1.448–18.386]; p = 0.011). The correlation between DWI lesion volume and initial NIHSS score was strong in patients without CDM (r = 0.731) but only moderate in patients with CDM (r = 0.355). Conclusion: Patients with both CDM and PDM had a better response to late-window EVT than those with PDM only.
Atypical Perfusion Manifestation in Migraine with Aura
Authors: Lester Jacobo , Bustamante Jesús Carlos , García-Moreno Carla , Klériga Enrique
Published: October 2021

Migraine with aura may be confused with a stroke. Magnetic resonance imaging is an important tool for the differential diagnosis. Cerebral hypoperfusion has been described in classic migraine, mainly during the aura. A 47-year-old male had an unremarkable past medical history. After sneezing, he developed a left hemi hypoesthesia, bitemporal vision loss, photopsia, and some distortion in the position of letters and words. This lasted <1 h, and it was followed by a severe headache. A magnetic resonance angiography was performed during the headache. It showed a left hemispheric hypoperfusion that did not correlate with the symptoms described by the patient. It is believed that during the aura, cerebral blood flow decreases, leading to hypoxia and decreased cellular energy generation, and these metabolic alterations define the symptoms of the patient. In our case, we documented brain hypoperfusion during the headache in the ipsilateral brain hemisphere to the symptoms, which has no clinical correlation. This condition could be due to spasm in the capillary arteries, and it may persist and influence the clinical manifestations during the headache phase in migraine with aura. A state of generalized cerebral hyperperfusion has been suggested, and there may be a coexistence of both phenomena for some period. This may open a new line of research regarding the pathophysiology and vascular changes of migraine with aura.
Is Additional Gastrectomy Required for Elderly Patients after Endoscopic Submucosal Dissection with Endoscopic Curability C-2 for Early Gastric Cancer?
Authors: Hatta Waku , Gotoda Takuji , Koike Tomoyuki , Uno Kaname , Asano Naoki , Imatani Akira , Masamune Atsushi
Published: October 2021

Background: With the ongoing growth of the aged population, the number of elderly patients suffering from gastric cancer has increased in Japan. Since the frequency of lymph node metastasis (LNM) in patients after endoscopic submucosal dissection (ESD) with endoscopic curability (eCura) C-2 for early gastric cancer (EGC) is relative low, the following question can be raised: “Is additional gastrectomy required for elderly patients with such criteria for ESD?” Summary: For therapeutic decision-making after ESD with eCura C-2, the risk of all-cause mortality and impaired quality of life (QoL) should thus be evaluated. Risk stratification of LNM and gastric cancer-specific mortality was established by the eCura system; however, it remains unclear how much these categories and treatment selection affect all-cause mortality. The contribution of prognostic tools for predicting all-cause mortality was noted to vary across the studies of patients with EGC; thus, further studies that investigate comprehensive geriatric assessment (CGA) may be required. Regarding the QoL, studies on elderly patients remain to be lacking. Furthermore, one of the issues with CGA and QoL tools is that they are time consuming. Key Messages: Combined evaluation of risk stratification of gastric cancer-specific mortality by the eCura system and risk of nongastric cancer-related mortality and impaired QoL may be the current optimal method to decide treatment strategy after ESD with eCura C-2 for EGC among elderly patients. A large-scale prospective study that investigates CGA domains is required to identify predictors of all-cause mortality and impaired QoL, and a more easily usable tool should be developed.
Impact of Legislation on Opioid Prescribing following Hysterectomy and Hysteroscopy in Arizona and Florida
Authors: Carrubba Aakriti R. , Glasgow Amy E. , Habermann Elizabeth B. , Stanton Amanda P. , Wasson Megan N. , DeStephano Christopher C.
Published: October 2021

Objectives: This study aimed to determine the oral morphine equivalents (OMEs) prescribed and refill rates following hysterectomy and hysteroscopy in the setting of opioid prescribing practice changes in 2 states. Design: This is a retrospective cohort analysis consisting of 2,916 patients undergoing hysterectomy or hysteroscopy between July 2016 and September 2019 at 2 affiliated academic hospitals in states that underwent legislative changes in opioid prescribing in 2018. Methods: Participants were identified using the Current Procedural Terminology procedure codes in Arizona and Florida. Hysterectomy was chosen as the most invasive gynecologic procedure, while hysteroscopy was chosen as the least invasive. Medical records were abstracted to find opioid prescriptions from 90 days before surgery to 30 days after discharge. Patients with opioid use between 90 and 7 days before surgery were excluded. Prescriptions were converted to OMEs and were calculated per quarter year. Statistical analysis included Wilcoxon rank sum t tests for OMEs and χ2 t tests for refill rates. Interrupted time-series analysis was used to determine significant change in OMEs before and after legislative change. Statistical analysis was performed using SAS version 9.4 (SAS Institute, Cary, NC, USA). Results: In Arizona, 1,067 hysterectomies were performed; 459 (43%) vaginal, 561 (52.6%) laparoscopic/robotic, and 47 (4.4%) abdominal. There were 530 hysteroscopies. Overall median OMEs decreased from 225 prior to July 2018 to 75 after July 2018 (p < 0.0001). The opioid refill rate remained unchanged at 7.4% (p = 0.966). In Florida, there were 769 hysterectomies; 241 (31.3%) vaginal, 476 (61.9%) laparoscopic/robotic, and 52 (6.8%) abdominal. There were 549 hysteroscopies. Overall median OMEs decreased from 150 prior to July 2018 to 0 after July 2018 (p < 0.0001). The opioid refill rate was similar (7.8% before July 2018 and 7.3% after July 2018; p = 0.739). Limitations: Limitations include involvement of a single hospital institution with a total of 10 fellowship-trained surgeons and biases inherent to retrospective study design. Conclusions: Legislative and provider-led changes coincided with decreases in opioid prescribing after 2018 in both states without increasing rates of refills and showed actual data reflected in the medical record. Gynecologists must actively participate in safe prescribing practices to decrease opioid dependence and misuse.
The 2021 European Training Requirements in Paediatric Endocrinology and Diabetes
Authors: Busiah Kanetee , Peet Aleksandr , Tornese Gianluca , Weintrob Naomi , Schulga John , Hamza Rasha T. , Koletzko Berthold , Russell Rob Ross , Felice Arthur , Patel Leena
Published: October 2021

The aims of the 2021 European Training Requirements (ETR) in Paediatric Endocrinology and Diabetes (PED) are to (1) provide standards to harmonize training programmes in PED between different European countries, (2) establish clearly defined standards of knowledge and skills required to practice PED at the tertiary care level, (3) foster the development of a network of competent tertiary care centres for PED in Europe and globally, and (4) improve the quality of care for children and adolescents requiring PED services. This ETR in PED specifies the requirements for training institutions, trainers, and trainees. It also provides the detailed syllabus/core content that trainees are expected to achieve in order to become competent independent clinicians in PED. References to consensus guidelines produced and/or endorsed by ESPE are included. The target users are trainees in PED, trainers, and all involved with quality assurance and accreditation. The process to develop and approve this 2021 ETR has been rigorous and involved trainees and consultants in paediatric and adult Endocrinology, ESPE (Syllabus Task Force, Education and Training Committee, Council), European Academy of Paediatrics (Tertiary Care Council, Assembly), European Board of Paediatrics, and Union of European Medical Specialists. Implementing the ETR will complement professional regulatory requirements for postgraduate training in PED in different countries and allow harmonizing standards across Europe. ETR is publicly available at www.eurospe.org/education/education-training-syllabus and at https://www.uems.eu/__data/assets/pdf_file/0007/133990/UEMS-2021.17-European-Training-Requirement-in-Paediatric-Endocrinology.pdf.
Candida Pneumonia: An Innocent Bystander or a Silent Killer?
Authors: Meena Durga Shankar , Kumar Deepak
Published: October 2021

Invasive candidiasis is predominantly seen in immunosuppressed patients and carries a significant mortality. The clinical spectrum of invasive candidiasis encompasses candidemia and disseminated infection (intra-abdominal abscess, osteomyelitis, endophthalmitis, and Candida meningitis). The existence of Candida pneumonia has been largely debated over the years due to its rarity and presence of frequent colonization. Demonstration of Candida species by lung biopsy along with evidence of inflammation is the only way to confirm this entity. The interpretation of Candida in respiratory specimens and the decision to initiate antifungal therapy is controversial due to the lack of clinical evidence. In this mini-review, we discuss the currently available clinical data from the literature on Candida pneumonia and future perspectives regarding the need for antifungal therapy in such patients.
Efficiency improvement of dual three-phase permanent magnet synchronous motor using modified switching table DTC for electric ship propulsion
Authors: Afia Aziz El , Hasoun Mhammed , Khafallah Mohamed , Benkirane Karim
Published: October 2021

A direct torque control using a classical switching- table ST-DTC can be used to control the torque and thus the speed of Dual Three-Phase Permanent Magnet Synchronous Motor (DTP-PMSM). The principle is based on direct application of control sequence by using two hysteresis regulators and a switching table. A large stator current containing low order harmonics is produced during the application of the classic ST-DTC technique, this leads to higher losses affecting the efficiency of the machine. To allow a reduction of these harmonics a modified switching-table approach based DTC technique is examined. Indeed, an improved ST-DTC strategy, which consist of replacing the vectors of the classical table with synthetic vectors, is discussed. The simulation results confirm the validity of the selected strategy.
Stator flux in direct torque control using a speed and torque variation-based sector rotation approach
Authors: Tarusan Siti Azura Ahmad , Jidin Auzani , Jamil Mohd Luqman Mohd , Karim Kasrul Abdul
Published: October 2021

A typical problem of traditional DTCs is that the stator flux fails to regulate at low running speeds. The regulation of stator flux in DTC is disrupted because of the unavoidable voltage drop across the stator resistance. As a result, one of the solutions to the problem is to use a fixed sector rotation technique. The concept is based on decreasing stator flux droop, a simple technique for changing the flux locus sector at a certain angle. This method, however, is only effective at low working speeds at one value of torque. As a result, the stator flux droop effect at various speeds as well as torque must be studied. The study is carried out in this paper using simulation (MATLAB/Simulink) and a practical setup (dSPACE board) where both have performed similar outcomes. The comparison is done between the conventional method (without a strategy) and the proposed method (with strategy). In summary, the effect of stator flux droop has been found to have an inverse linear relationship to the speed and torque variation.
Real time implementation of anti-windup PI controller for speed control of induction machine based on DTC strategy
Authors: Ouboubker Lahcen , Lamterkati Jawad , Khafallah Mohamed , El Afia Aziz
Published: October 2021

This paper presents simulation and experimental results of anti-windup PI controller to improve induction machine speed control based on direct torque control (DTC) strategy. Problems like rollover can arise in conventional PI controller due to saturation effect. In order to avoid such problems anti-windup PI controller is presented. This controller is simple for implementation in practice. The proposed anti-windup PI controller demonstrates better dynamic step changes response in speed in terms of overshoots. All simulation work was done using Simulink in the MATLAB software. The experimental results were obtained by practical implementation on a dSPACE 1104 board for a 1.5 KW induction machine. Simulation and experimental results have proven a good performance and verified the validity of the presented control strategy.
An efficient dynamic power management model for a stand-alone DC Microgrid using CPIHC technique
Authors: Sharmila N. , Nataraj K. R. , Rekha K. R.
Published: October 2021

The power generation using solar photovoltaic (PV) system in microgrid requires energy storage system due to their dilute and intermittent nature. The system requires efficient control techniques to ensure the reliable operation of the microgrid. This work presents dynamic power management using a decentralized approach. The control techniques in microgrid including droop controllers in cascade with proportional-integral (PI) controllers for voltage stability and power balance have few limitations. PI controllers alone will not ensure microgrid’s stability. Their parameters cannot be optimized for varying demand and have a slow transient response which increases the settling time. The droop controllers have lower efficiency. The load power variation and steady-state voltage error make the droop control ineffective. This paper presents a control scheme for dynamic power management by incorporating the combined PI and hysteresis controller (CPIHC) technique. The system becomes robust, performs well under varying demand conditions, and shows a faster dynamic response. The proposed DC microgrid has solar PV as an energy source, a lead-acid battery as the energy storage system, constant and dynamic loads. The simulation results show the proposed CPIHC technique efficiently manages the dynamic power, regulates DC link voltage and battery’s state of charge (SoC) compared to conventional combined PI and droop controller (CPIDC).
Hybrid nonlinear control strategies for performance enhancement of a doubly-fed induction aero-generator: design and DSP implementation
Authors: Rached Bouchaib , Elharoussi Mustapha , Abdelmounim Elhassane
Published: October 2021

This paper reports on the design and implementation in DSP as hardware in the loop of a nonlinear control strategy for a grid-connected variable speed wind turbine using a doubly fed induction generator (DFIG). The objective of this work is to build a real-time nonlinear hybrid approach combining Backstepping control and sliding mode control strategies for DFIG used in wind energy conversion systems (WECS). The results of the DSP implementation are discussed and qualitative and quantitative performance evaluations are performed under various disturbed conditions. The implementation is performed using the TMS320F28335 DSP combined with the MATLAB/Simulink (2016a) environment. The experimental results have been satisfactorily achieved, which implies that the proposed strategy is an efficient and robust approach to monitor the WECS.
Active cooling photovoltaic with IoT facility
Authors: Kamarudin Muhammad Nizam , Rozali Sahazati Md. , Jamri Mohd Saifuzam
Published: October 2021

Harvesting energy from the sun makes the photovoltaic (PV) power generation a promising technology. To obtain a consistent state of charge (SOC), consistent energy must be harvested and efficiently directed to the battery. Overcharging or undercharging phenomena decreases the lifetime of the battery. Besides, the effect of irradiance toward solar in term of sunlight intensity effects the efficiency and hence, sluggish the SOC. The main problem of the solar panel revealed when the temperature has increased, the efficiency of solar panel will also be decreased. This manuscript reports the finding of developing an automatic active cooling system for a solar panel with a real time energy monitoring system with internet-of-things (IoT) facility. The IoT technology assists user to measure the efficiency of the solar panel and SOC of the battery in real time from any locations. The automatic active cooling system is designed to improve the efficiency of the solar panel. The effectiveness of the proposed system is proven via the analysis of the effect of active cooling toward efficiency and SOC of photovoltaic system. The results also tabulate the comparative studies of active-to-passive cooling system, as well as the effect of cooling towards SOC and efficiency of the solar panel.
Modeling and design of an adaptive control for VSC-HVDC system under parameters uncertainties
Authors: Kazi Mohamed Amine , Majdoul Radouane , Machkour Nadia
Published: October 2021

The growing demand for electricity and the increasing integration of clean energies into the electrical grids requires the multiplication and reinforcement of high-voltage direct current (HVDC) projects throughout the world and demonstrates the interest in this electricity transmission technology. The transmitting system of the voltage source converter-high-voltage direct current (VSC-HVDC) consists primarily of two converter stations that are connected by a dc cable. In this paper, a nonlinear control based on the backstepping approach is proposed to improve the dynamic performance of a VSC-HVDC transmission system, these transport systems are characterized by different complexities such as parametric uncertainties, coupled state variables, neglected dynamics, presents a very interesting research topic. Our contribution through adaptive control based on the backstepping approach allows regulating the direct current (DC) bus voltage and the active and reactive powers of the converter stations. Finally, the validity of the proposed control has been verified under various operating conditions by simulation in the MATLAB/Simulink environment.
LCL filter design for grid-connected single-phase flyback microinverter: a step by step guide
Authors: Yaakub Muhamad Faizal , Radzi Mohd Amran Mohd , Azri Maaspaliza , Noh Faridah Hanim Mohd
Published: October 2021

Recently, LCL has become amongst the most attractive filter used for grid-connected flyback inverters. Nonetheless, the switching of power devices in the inverter configuration creates harmonics that affect the end application behavior and might shorten its lifetime. Furthermore, the resonance frequencies produced by the LCL network contribute to the system instability. This paper proposes a step-by-step guide to designing an LCL filter by considering several key aspects such as the resonance frequency and maximum current ripple. A single-phase grid-connected flyback microinverter with an LCL filter was designed then constructed in the MATLAB/Simulink environment. Several different parameter variations and damping solutions were used to analyze the performance of the circuit. The simulation result shows a promising total harmonic distortion (THD) value below 5% and harmonic suppression up to 14%.
The new approach minimizes harmonics in a single-phase three-level NPC 400 Hz converter for airplanes
Authors: Quy Do Ngoc , Ba Phu Do , Kien Trung Nguyen
Published: October 2021

This paper provides a new approach to reducing high-order harmonics in 400 Hz inverter using a three-level neutral-point clamped (NPC) converter. A voltage control loop using the harmonic compensation combined with NPC clamping diode control technology. The capacitor voltage imbalance also causes harmonics in the output voltage. For 400 Hz inverter, maintain a balanced voltage between the two input (direct current) (DC) capacitors is difficult because the pulse width modulation (PWM) modulation frequency ratio is low compared to the frequency of the output voltage. A method of determining the current flowing into the capacitor to control the voltage on the two balanced capacitors to ensure fast response reversal is also given in this paper. The combination of a high-harmonic resonator controller and a neutral-point voltage controller working together on the 400 Hz NPC inverter structure is given in this paper.
Prospect of renewable energy resources in Bangladesh
Authors: Rahman Mohammad Mafizur , Begum Feroza
Published: October 2021

The objective of this paper is to provide an overview of the current state of renewable energy resources in Bangladesh, as well as to examine various forms of renewable energies in order to gain a comprehensive understanding of how to address Bangladesh's power crisis issues in a sustainable manner. Electricity is currently the most useful kind of energy in Bangladesh. It has a substantial influence on a country's socioeconomic standing and living standards. Maintaining a stable source of energy at a cost that is affordable to everyone has been a constant battle for decades. Bangladesh is blessed with a wealth of natural resources. Bangladesh has a huge opportunity to accelerate its economic development while increasing energy access, livelihoods, and health for millions of people in a sustainable way due to the renewable energy system.
Antiplatelet Use and Ischemic Stroke Risk in Minor Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the POINT Trial
Authors: Anadani Mohammad , de Havenon Adam , Henninger Nils , Kuohn Lindsey , Mac Grory Brian , Furie Karen L. , Kim Anthony S. , Easton J. Donald , Johnston S. Claiborne , Yaghi Shadi
Published: October 2021

Background and Purpose:

Dual antiplatelet therapy has been shown to reduce the risk of recurrent stroke in patients with minor stroke or transient ischemic attack. However, whether the effect of dual antiplatelet therapy is modified by pretreatment antiplatelet status is unclear.

Methods:

This is a post hoc analysis of the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke). Patients were divided into 2 groups based on pretreatment antiplatelet use. The primary outcome was ischemic stroke within 90 days of randomization.

Results:

We included 4881 patients of whom 41% belonged to the no pretreatment antiplatelet. Ischemic stroke occurred in 6% and 5% in the antiplatelet pretreatment and no antiplatelet pretreatment, respectively. Antiplatelet pretreatment was not associated with the risk of ischemic stroke (adjusted hazard ratio, 1.05 [95% CI, 0.81–137]) or risk of major hemorrhage (hazard ratio, 1.10 [95% CI, 0.55–2.21];
P
=0.794). The effect of dual antiplatelet therapy on recurrent ischemic stroke risk was not different in patients who were on antiplatelet before randomization (adjusted hazard ratio, 0.69 [95% CI, 0.50–0.94]) as opposed to those who were not (adjusted hazard ratio, 0.75 [95% CI, 0.50–1.12]),
P
for interaction = 0.685.

Conclusions:

In patients with minor stroke and high-risk transient ischemic attack, dual antiplatelet therapy reduces the risk of ischemic stroke regardless of premorbid antiplatelet use.