bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Based Reactivity Prediction of Fly Ash Type F Produced from South Korea
Authors: Park Woo-Young , Moon Juhyuk
Published: November 2023

Fly ash (FA) is the most commonly used supplementary cementitious material in the world. However, the reactivity of FA varies substantially. In this study, new machine learning (ML) model has been developed to efficiently predict the amorphous content in FA type F. Compared to the existing ML model using types F and C of FA from different countries, this study more focused on the improved prediction of FA type F only produced from South Korea. It was found that the contents of CaO and SiO2 impact high in predicting the amount of aluminosilicate glass. However, the contribution of Al2O3 and Fe2O3 are ranked differently. The improved model algorithm was proposed as a combination of three ensemble techniques of bagging, boosting, and stacking. As a result of the test, the final model shows $${R}^{2}$$

R

2

of 0.80 in predicting the amount of aluminosilicate glass in FA type F.
New aspects of the upper atmospheric disturbances caused by the explosive eruption of the 2022 Hunga Tonga–Hunga Ha’apai volcano
Authors: Shinbori Atsuki , Otsuka Yuichi , Sori Takuya , Nishioka Michi , Septi Perwitasari , Tsuda Takuo , Nishitani Nozomu , Kumamoto Atsushi , Tsuchiya Fuminori , Matsuda Shoya , Kasahara Yoshiya , Matsuoka Ayako , Nakamura Satoko , Miyoshi Yoshizumi , Shinohara Iku
Published: November 2023

The Hunga Tonga–Hunga Ha’apai (HTHH) undersea volcanic eruption that occurred at 04:15 UT on 15 January 2022 is one of the most explosive events in the modern era, and a vertical plume reached approximately 55 km, corresponding to a height of the lower mesosphere. The intense explosion and subsequent plume generated acoustic and atmospheric gravity waves detected by ground-based instruments worldwide. Because a global-scale atmospheric and ionospheric response to the large volcanic eruption has not yet been observed, it provides a unique opportunity to promote interdisciplinary studies of coupling processes in lithosphere–atmosphere–ionosphere with ground-based and satellite observations and modeling. Further, this event allows us to elucidate the propagation and occurrence features of traveling ionospheric disturbances, the generation of equatorial plasma bubbles, the cause of electron density holes around the volcano, and the magnetic conjugacy of magnetic field perturbations. The most notable point among these studies is that the medium-scale travelling traveling ionospheric disturbances (MSTIDs) have magnetic conjugacy even in the daytime ionosphere and are generated by an external electric field, such as an E-region dynamo field, due to the motions of neutrals in the thermosphere. This advocates a new generation mechanism of MSTIDs other than the neutral oscillation associated with atmospheric gravity waves and electrified MSTIDs, which are frequently observed during daytime and nighttime, respectively. This paper reviews the recent studies of atmospheric and ionospheric disturbances after the HTHH volcanic eruption and summarizes what we know from this extreme event analysis. Further, we analyzed new datasets not shown in previous studies to give some new insights to understanding of some related phenomena. As a result, we also found that 4-min plasma flow oscillations caused by the acoustic resonance appeared with the amplitude of approximately 30 m/s in the northern hemisphere a few hours before the initial arrival of the air pressure waves. The propagation direction was westward, which is the same as that of the daytime MSTIDs with a magnetic conjugate feature. This result suggests that the 4-min oscillations are generated by an external electric field transmitted to the northern hemisphere along magnetic field lines.

Graphical Abstract
Pneumo-mediastinum, pneumoperitoneum, and pneumo-scrotum with extensive increasing subcutaneous emphysema: a rare presentation of colonic perforation
Authors: Haldeniya Kulbhushan , Krishna S. R. , Raghavendra Annagiri , Singh Pawan Kumar
Published: November 2023

Background

Colonic perforation usually presents with classical signs of peritonitis. However, isolated retroperitoneal colonic perforation can present with varied clinical signs and symptoms and pose diagnostic challenges. Pneumo-mediastinum and abdominal subcutaneous emphysema can be one of the presenting signs of colonic perforation.

Case report

A 33-year-old male presented with abdominal distension and extensive subcutaneous emphysema over the abdomen, pneumo-mediastinum, and pneumo-scrotum secondary to sigmoid colon perforation from a foreign body. The patient did not have classical signs of peritonitis.

Conclusion

Being vigilant about the potential of colonic perforation is crucial when observing a significantly increasing subcutaneous emphysema across different parts of the body. Attending clinicians should always keep intraabdominal pathology in mind when a direct cause for these symptoms cannot be found and the patient’s symptoms become progressive.
Time-lapse attenuation variations using distributed acoustic sensing vertical seismic profile data during CO2 injection at CaMI Field Research Station, Alberta, Canada
Authors: Wang Yichuan , Lawton Donald C.
Published: November 2023

For seismic monitoring of geologic [Formula: see text] storage, it is useful to measure time-lapse (TL) variations of seismic attenuation. Seismic attenuation directly connects to different petrophysical parameters within the [Formula: see text] storage complex. We have developed an approach to derive smooth time-variant amplitude spectra from seismic signals by using the sparse strongest signal peaks, and then measuring two different attributes (conventional Q factor and its “geometric” counterpart) characterizing the path effects of seismic attenuation from the smooth spectra. This approach is straightforward and does not require sophisticated algorithms or parameterization schemes. We apply this approach to TL distributed acoustic sensing (DAS) vertical seismic profile (VSP) data from the Field Research Station (FRS) [Formula: see text] injection project in southern Alberta, Canada. High-quality stacked reflection records are obtained from the baseline and monitor DAS VSP surveys at the FRS and TL attenuation-attribute differences are derived from these reflection records. TL variations of attenuation are observed within the injection zone at the FRS, which are interpreted as being related to the injected [Formula: see text]. Although there is always a significant trade-off between the accuracy and temporal resolution of the measured attenuation parameters, reliable attenuation measurements around the injection zone are still achieved with an in-use reflection signal of a sufficient length and bandwidth. Attenuation attributes measured from this approach can be an advantageous tool for monitoring the distribution and migration of [Formula: see text] plumes.
Predictive Value of Minimal Residual Disease for Efficacy of Rituximab Maintenance in Mantle Cell Lymphoma: Results From the European Mantle Cell Lymphoma Elderly Trial
Authors: Hoster Eva , Delfau-Larue Marie-Hélène , Macintyre Elizabeth , Jiang Linmiao , Stilgenbauer Stephan , Vehling-Kaiser Ursula , Salles Gilles , Thieblemont Catherine , Tilly Hervé , Wirths Stefan , Feugier Pierre , Hübel Kai , Schmidt Christian , Ribrag Vincent , Kluin-Nelemans Johanna C. , Dreyling Martin , Pott Christiane ,   on behalf of the European MCL MRD Working Group and the European MCL Network
Published: November 2023

PURPOSE

The outcome of older patients with mantle cell lymphoma (MCL) has improved by the introduction of immunochemotherapy, followed by rituximab (R)-maintenance. Assessment of minimal residual disease (MRD) represents a promising tool for individualized treatment decisions and was a prospectively planned part of the European MCL Elderly trial. We investigated how MRD status influenced the efficacy of R-maintenance and how MRD can enable tailored consolidation strategies.

PATIENTS AND METHODS

Previously untreated patients with MCL age 60 years or older have been randomly assigned to R versus interferon-alpha maintenance after response to rituximab, fludarabine, cyclophosphamide (R-FC) versus rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP). MRD monitoring was performed by real-time quantitative polymerase chain reaction (qPCR) following EuroMRD guidelines.

RESULTS

A qPCR assay with a median sensitivity of 1 × 10−5 could be generated in 80% of 288 patients in an international, multicenter, multilaboratory setting. More extensive tumor dissemination facilitated the identification of a molecular marker. The efficacy of R-maintenance in clinical remission was confirmed for MRD-negative patients at the end of induction in terms of progression-free survival (PFS; hazard ratio [HR], 0.38 [95% CI, 0.21 to 0.63]) and overall survival (OS; HR, 0.37 [95% CI, 0.20 to 0.68]), particularly in R-CHOP–treated patients (PFS-HR, 0.23 [95% CI, 0.10 to 0.52]; OS-HR, 0.19 [95% CI, 0.07 to 0.52]). R-maintenance appeared less effective in MRD-positive patients (PFS-HR, 0.51 [95% CI, 0.26 to 1.02]) overall and after R-CHOP induction (PFS-HR, 0.59 [95% CI, 0.28 to 1.26]). R-FC achieved more frequent and faster MRD clearance compared with R-CHOP. MRD positivity in clinical remission after induction was associated with a short median time to clinical progression of approximately 1-1.7 years.

CONCLUSION

The results confirm the strong efficacy of R-maintenance in patients who are MRD-negative after induction. Treatment de-escalation for MRD-negative patients is discouraged by our results. More effective consolidation strategies should be explored in MRD-positive patients to improve their long-term prognosis.
Rate of Pathogenic Germline Variants in Patients With Lung Cancer
Authors: Sorscher Steven , LoPiccolo Jaclyn , Heald Brandie , Chen Elaine , Bristow Sara L. , Michalski Scott T. , Nielsen Sarah M. , Lacoste Alix , Keyder Emil , Lee Hayan , Nussbaum Robert L. , Martins Renato , Esplin Edward D.
Published: November 2023

PURPOSE

Germline genetic testing (GGT) is now recommended for all patients diagnosed with ovarian or pancreatic cancer and for a large proportion of patients based solely on a diagnosis of colorectal or breast cancer. However, GGT is not yet recommended for all patients diagnosed with lung cancer (LC), primarily because of a lack of evidence that supports a significant frequency of identifying pathogenic germline variants (PGVs) in these patients. This study characterizes GGT results in a cohort of patients with LC.

METHODS

We reviewed deidentified data for 7,788 patients with GGT (2015-2022). PGV frequencies were compared to a control cohort of unaffected individuals. GGT results were stratified by genomic ancestry, history of cancer, and PGV clinical actionability per current guidelines.

RESULTS

Of all patients with LC, 14.9% (1,161/7,788) had PGVs. The rate was similar when restricted to patients with no cancer family history (FH) or personal history (PH) of other cancers (14.3%). PGVs were significantly enriched in BRCA2, ATM, CHEK2, BRCA1, and mismatch repair genes compared with controls. Patients of European (EUR) genomic ancestry had the highest PGV rate (18%) and variants of uncertain significance were significantly higher in patients of non-EUR genomic ancestry. Of the PGVs identified, 61.3% were in DNA damage repair (DDR) genes and 95% were clinically actionable.

CONCLUSION

This retrospective study shows a LC diagnosis identifies patients with a significant likelihood of having a cancer-predisposing PGV across genomic ancestries. Enrichment of PGVs in DDR genes suggests that these PGVs may contribute to LC cancer predisposition. The frequency of PGVs among patients with LC did not differ significantly according to FH or PH of other cancers.
Targeted Approaches to Treatment of Pleural Mesothelioma: A Review
Authors: Dagogo-Jack Ibiayi
Published: November 2023

Pleural mesothelioma is an aggressive disease that is enriched for inactivating alterations in tumor suppressor genes. Systemic therapeutic strategies for pleural mesothelioma generally involve chemotherapies and immunotherapies that are chosen without consideration of the tumor's molecular profile. As this generalized approach to treatment rarely yields durable responses, alternative therapeutic regimens are urgently indicated. Preclinical studies have identified synthetic lethal protein and metabolic interactions, recurrently overexpressed proteins, and frequent pathway perturbations that may be therapeutically exploited in mesothelioma. This review discusses the mechanism of action of emerging investigational therapies and summarizes findings from phase I-II clinical trials exploring selective, biomarker-driven therapeutic strategies for mesothelioma, with a focus on five common targets. Finally, using lessons learned from these clinical trials, imperatives for successful implementation of targeted therapy in mesothelioma are discussed.
Improvement of Pulmonary Function and Reconstructed 3-Dimensional Lung Volume After Halo-Pelvic Traction Combined With Posterior Correction for Severe Rigid Spinal Scoliosis: A Multicenter Study
Authors: Liu Zhiming , Zhong Junlong , Ma Shengbiao , Yang Cao , Wan Wenbing , Wan Zongmiao , Mamat Mardan , Wang Yingsong , Ge Zhaohui , Cao Kai
Published: November 2023

BACKGROUND AND OBJECTIVES:

Severe rigid spinal scoliosis (SRSS) leads to severe restrictive ventilation dysfunction. Currently, the reports about the influence of preoperative halo-pelvic traction (HPT) combined with correction surgery on pulmonary function in patients with SRSS were relatively few. This study aims to investigate (1) the influence of preoperative HPT on lung volume and pulmonary function, (2) the further influence of the following correction surgery on lung volume and pulmonary function, and (3) the relationship among deformity correction, pulmonary function test outcomes, and computed tomography–based lung volume.

METHODS:

A total of 135 patients with SRSS who underwent preoperative HPT and followed low-grade osteotomy correction surgery were reviewed. Spinal parameters, including proximal thoracic curve, main thoracic curve (MTC), lumbar curve, coronal balance, thoracic kyphosis, lumbar lordosis, sagittal vertical axis, pulmonary function test outcomes (forced vital capacity [FVC], the percentage of predicted forced vital capacity [FVC%], forced expiratory volume in 1 second [FEV1], total lung capacity [TLC]), and lung volume (Vin), were analyzed before, after HPT and at the final follow-up, respectively.

RESULTS:

The mean FVC, FVC%, FEV1, and TLC increased from 1.67 L, 51.13%, 1.47 L, and 2.37 L to 1.95 L, 64.35%, 1.75 L, and 2.78 L, respectively, after HPT and further improved to 2.22 L, 72.14%, 1.95 L, and 3.15 L, respectively, at the final follow-up. The mean Vin increased from 1.98 L to 2.42 L after traction and further increased to 2.76 L at the final follow-up. The variation of MTC was correlated with the improvement of FVC (r = 0.429, P = .026), FVC% (r = 0.401, P = .038), FEV1 (r = 0.340, P = .043), and TLC (r = 0.421, P = .029) and the variation of Vin (r = 0.425, P = .015) before HPT and after surgery.

CONCLUSION:

Preoperative HPT can improve preoperative pulmonary function and enhance the preoperative lung volume. There were significant correlations among the variations of MTC, pulmonary function indexes, and lung volume before HPT and after surgery in patients with SRSS.
Does aquatic performance predict terrestrial performance: a case study with an aquatic frog, Xenopus laevis
Authors: Araspin Laurie , Measey John , Herrel Anthony
Published: November 2023

The physical properties of the environment impose strong selection on organisms and their form–function relationships. In water and on land, selective pressures differ, with water being more viscous and denser than air, and gravity being the most important external force on land for relatively large animals such as vertebrates. These different properties of the environment could drive variation in the design and mechanics of the locomotor system of organisms. Animals that use multiple environments can consequently exhibit locomotion conflicts between the demands imposed by the media, leading to potential trade-offs. Here, we tested for the presence of such locomotor trade-offs depending on the environment (water or land) in a largely aquatic frog, Xenopus laevis. We focused on terrestrial and aquatic exertion capacity (time and distance swum or jumped until exhaustion) and aquatic and terrestrial burst capacity (maximal instantaneous swimming velocity and maximal force jump) given the ecological relevance of these traits. We tested these performance traits for trade-offs, depending on environments (water versus air) and locomotor modes (i.e. exertion and burst performance). Finally, we assessed the contribution of morphological traits to each performance trait. Our data show no trade-offs between the performance traits and between the environments, suggesting that X. laevis is equally good at swimming and jumping thanks to the same underlying morphological specialisations. We did observe, however, that morphological predictors differed depending on the environment, with variation in head shape and forelimb length being good predictors for aquatic locomotion and variation in hindlimb and forelimb segments predicting variation in jumping performance on land.
Ο φυτικός κόσμος της Αιγύπτου υπό το φως των ελληνικών παπύρων
Authors: Δράκος Ιωάννης
Published: November 2023

Η παρούσα διδακτορική διατριβή διερευνά τον ρόλο που διαδραμάτιζαν τα ανθοφόρα φυτά τριανταφυλλιά (ῥόδον; Rosa spp.), παπαρούνα (μήκων; Papaver spp.), ατρακτυλίδα (κνῆκος; Carthamus tinctorius), κρόκος (κρόκος; Crocus sativus L.) και μαύρο κύμινο (μελάνθιον; Nigella spp.), σε διάφορες πτυχές της ζωής των κατοίκων της χώρας του Νείλου από τα ελληνιστικά έως τα όψιμα βυζαντινά χρόνια υπό το φως των ελληνικών παπύρων. Η έρευνα - desideratum στον χώρο της Παπυρολογίας, καθώς καλύπτει ένα ερευνητικό κενό - στηρίζεται κυρίως στη μελέτη και αξιοποίηση των δημοσιευμένου αρχειακού υλικού (ελληνικών παπυρικών εγγράφων και οστράκων), παραφιλολογικών και μαγικών παπύρων, που συνεξετάζονται όμως με τις πηγές της αρχαίας ελληνικής Γραμματείας καθώς και με αρχαιολογικές και αρχαιοβοτανικές μελέτες. Ειδικότερα, η διδακτορική διατριβή διαρθρώνεται σε πρώτο επίπεδο με βάση τα πέντε εξεταζόμενα φυτικά είδη και σε δεύτερο επίπεδο θεματικά (ορολογία, καλλιέργεια κ. ο. κ.). Στη θεματική ενότητα της ‘Ορολογίας’ συγκεντρώνεται και εξετάζεται αναλυτικά η παπυρική ορολογία του εξεταζόμενου φυτικού είδους. Η ενότητα ‘Καλλιέργεια’ επικεντρώνεται σε ζητήματα που αφορούν στην καλλιέργεια των φυτών, ενώ δίνει παράλληλα έμφαση στην προέλευσή τους (ενδημικά ή εξωτικά φυτά) αλλά και τον καλλιεργητικό τους κύκλο. Η ενότητα ‘Οικονομία-Φορολογία’ πραγματεύεται την εμπορική σημασία κάθε φυτού στο πλαίσιο της αγροτικής οικονομίας της Αιγύπτου. Θέμα του κεφαλαίου των ‘Χρήσεων στην καθημερινή ζωή’ είναι η μελέτη των πρακτικών εφαρμογών τόσο των συγκεκριμένων φυτών όσο και των μεταποιητικών προϊόντων τους στον καθημερινό βίο των Ελληνοαιγυπτίων. Η ενότητα ‘Ιατρική’ αναδιφά στις φαρμακευτικές ιδιότητες των υπό εξέταση βοτάνων και τον τρόπο αξιοποίησής τους στα σκευάσματα των ιατρικών παπύρων. Στην ενότητα της ‘Θρησκείας’ παρουσιάζεται ο θρησκευτικός και τελετουργικός ρόλος των φυτών στο πλαίσιο του σύνθετου θρησκευτικού υποβάθρου της ελληνορρωμαϊκής και βυζαντινής Αιγύπτου. Η ενότητα ‘Μαγεία’ επικεντρώνεται στα παπυρικά corpora PGM και PDM, με σκοπό να εξετάσει τις ‘μαγικές’ ιδιότητες των υπό εξέταση βοτάνων σε συγκεκριμένα μαγικά εγχειρίδια και συνταγές. Τέλος, επιχειρείται μία συγκριτική εξέταση των πέντε φυτών.
Γραφή και εικόνα
Authors: Μελή Άννα
Published: November 2023

Η παρούσα έρευνα αφορά στην εξέταση του ψηφιακού υποστρώματος στο οποίο εντάσσεται η γραφή ως μέσο αφήγησης. Διερευνώνται οι σύγχρονες δυνατότητες γραφής στο τρισδιάστατο ψηφιακό περιβάλλον: σε χώρους που επαυξάνουν την όψη της πραγματικότητας, και σε τρισδιάστατους εμβυθιστικούς χώρους. Η έρευνα αναπτύσσεται μέσα από συγκριτική μελέτη της εξέλιξης της επιφάνειας της γραφής, και των βασικών ιδιοτήτων που αξιοποιούν οι άνθρωποι για να τοποθετήσουν αράδες κειμένου σε κάθε νέο «μηχανισμό». Καταγράφονται ορισμένες δομές που μπορεί να ορίσει ο γραφέας πάνω σε μια δεδομένη επιφάνεια, οι οποίες με τη σειρά τους επιβάλλουν αντίστοιχους τρόπους ανάγνωσης. Εντοπίζονται και αναλύονται σημαντικά στοιχεία της σχέσης «γραφέα-αναγνώστη-υποστρώματος» μέσα σε ένα τρισδιάστατο ψηφιακό περιβάλλον, όπως είναι ο προσανατολισμός των γραμμάτων, η ευαναγνωσιμότητα και η προοπτική, η κλίμακα, η κίνηση, το τρισδιάστατο πλαίσιο κειμένου, και η σωματικότητα που απαιτείται για την ανάγνωση. Η ένταξη των παραπάνω στοιχείων σε πειραματικές μελέτες διαφορετικών περιπτώσεων γραφής σε διαβαθμίσεις ψηφιακών περιβαλλόντων, που έγιναν για τις ανάγκες της διατριβής, ανέδειξε την ανάγκη ορισμού ενός ολοκληρωμένου νέου μηχανισμού επεξεργασίας κειμένου στον τρισδιάστατο χώρο, ο οποίος να αξιοποιεί το σύνολο των ειδικών χαρακτηριστικών του. Πρόκειται για ένα σύγχρονο εργαλείο γραφής και ανάγνωσης, το οποίο θα εντάσσει πλήρως τόσο τον γραφέα όσο και τον αναγνώστη, μέσω εμβύθισης, δημιουργώντας ένα τρισδιάστατο περιβάλλον αφήγησης. Η έρευνα δεν εξαντλεί τα στοιχεία, σε σχέση με το μεγάλο εύρος δυνατοτήτων, αλλά ανοίγει ένα πεδίο για μελλοντική έρευνα και πειραματισμό προς πολλούς χώρους που έχουν σχέση με μια εξελιγμένη μορφή εγγραφής λόγου.
Η ιατρική στη Θράκη
Authors: Κυρκούδης Θεόδωρος
Published: November 2023

Στην παρούσα διατριβή καταγράφηκε η άσκηση της ιατρικής στην ενιαία Θράκη από τον 18ο αιώνα μέχρι τα μέσα του 20ου. Έγινε αναφορά των σπουδαιότερων θρακών ιατρών της Κωνσταντινούπολης και της Θράκης: Ανατολικής, Δυτικής και Βόρειας. Σε κάθε θρακική πόλη και χωριό αναφέρθηκαν ενδελεχώς οι επιστήμονες, που άσκησαν την ιατρική. Για τους πλέον διακεκριμένους εξ’ αυτών, περιγράφηκε το ιατρικό και συγγραφικό τους έργο, η κοινωνική τους προσφορά και τα επιτεύγματά τους στους τομείς της επιστήμης, της τέχνης και της πολιτικής. Καταγράφηκαν λεπτομέρειες από τις σπουδές τους στα ευρωπαϊκά και εγχώρια πανεπιστήμια της εποχής. Οι καταγεγραμμένοι ιατροί υπήρξαν επιφανείς και ξεχώρισαν στις ιδιαίτερες πατρίδες τους για τις ιατρικές πράξεις τους όπως και για τις δωρεές και ευεργεσίες τους. Ιδιαίτερα κεφάλαια υπάρχουν για εξαιρετικά γεγονότα και εξέχουσες προσωπικότητες μεταξύ των οποίων περιγράφονται και γυναίκες με ιδιαίτερη προσφορά, παρά τις δύσκολες κοινωνικές συνθήκες της εποχής για τη θέση της γυναίκας. Για την έρευνα και τον εντοπισμό όλων των στοιχείων αυτών, χρησιμοποιήθηκαν ιστορικά αρχεία, ιδιωτικά κυρίως, που μετά από την παραχώρηση των ιδιοκτητών τους αποτελούν πρωτότυπα και άγνωστα στοιχεία για την έρευνα μέχρι σήμερα. Σπάνια και μοναδικά τεκμήρια (αδημοσίευτα έγγραφα, φωτογραφίες, βιβλιάρια σπουδών, αναλυτικές βαθμολογίες, βεβαιώσεις) καταγράφηκαν και αναδείχθηκαν για πρώτη φορά. Από αυτά, σταχυολογήθηκαν διακόσιες μία (201) εικόνες, εκ των οποίων οι ογδόντα τέσσερις (84) είναι αδημοσίευτες και κάποιες μοναδικές στο είδος τους. Η πληθώρα των στοιχείων που συγκεντρώθηκαν, μελετήθηκαν και παρουσιάσθηκαν στην παρούσα διατριβή, στο πλαίσιο της καταγραφής της ιστορίας της ιατρικής στη Θράκη, αποτελεί καινοτόμα προσφορά και δικαιώνει τον σκοπό της.
Case Report: Disseminated hydatid cyst: Unusual presentation and therapeutic challenges
Authors: Mohamed Babiker Anas , Abdelrahman Amro , Abdalkarim Asmaa , Algaly Gufran , Sanosi Amin , Mohamed Abdalla Elhassan , Zaki Hany A , Elgassim Moayad , Abdeen Muhnad , Elgassim Mohamed
Published: November 2023

Introduction: Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu lato, is a parasitic disease prevalent in endemic regions. CE frequently leads to the formation of hydatid cysts in various organs, with the liver being the most commonly affected site. Involvement of the spleen has been rarely reported in the literature. Managing disseminated hydatid cyst disease presents significant diagnostic and therapeutic challenges. Case presentation: A 40-year-old female with a past medical history of hypothyroidism presented with sudden onset shortness of breath, dry cough, and chest pain for 3 days. She had a recent travel history to Egypt. Physical examination revealed mild right upper quadrant tenderness. Laboratory findings showed elevated white blood cell count with eosinophilia and increased inflammatory markers. Chest X-ray and pan-computed tomography (Pan-CT) scans identified multiple cystic lesions in the lung, liver and spleen. Serological tests confirmed the presence of anti-Echinococcus antibodies, leading to a diagnosis of disseminated hydatid cyst disease. The patient was managed medically and surgically by a multidisciplinary team. Conclusion: Disseminated hydatid cyst disease, though rare, presents complex diagnostic and management challenges. Timely recognition, supported by clinical, radiological, and serological assessments, is essential. Surgical intervention should be considered in a patient when multiple extrahepatic cysts are present, and rupture is evident, as this approach can significantly reduce patient morbidity and mitigate life-threatening complications.
INFANCIA, MODERNIDAD, ARQUITECTURA Y ACCIÓN
Authors: Añón Abajas Rosa María , Ramos-Carranza Amadeo
Published: November 2023

Se indaga sobre la capacidad de la infancia para orientar a la arquitectura hacia su misión social y educadora. También se aborda el potencial educativo de la acción arquitectónica. Las investigaciones tratadas presentan casos que incluyen a la infancia como sujeto activo. Se exponen experiencias recientes que trabajan aplicando la metodología crítica de la creatividad arquitectónica para propiciar una educación general en capacidades artísticas, sociales, espaciales y políticas. Estas prácticas es-tán proliferando incentivadas desde instituciones internacionales decisivas para la cooperación y el desarrollo; en cierto modo son novedosas, pero encontraremos precedentes admirables de este tipo de actividades que, consideradas utópicas en su momento y, como tales, ignoradas, ahora demuestran su pertinencia. Podemos concluir que los modelos educativos evolucionan como conse-cuencia de las crisis y carencias que marcan a la sociedad propiciando las utopías que definen sus ciclos. PALABRAS CLAVE educación; casa; jardín; ciudad; juegos; teatro
LUGARES PARA LA AVENTURA: TRES ACCIONES INCIDENTALES
Authors: Tuset Davó Juan José
Published: November 2023

En los años sesenta del siglo xx, el concepto de aventura se asoció a un tipo de parques de juegos infantiles que se creía la solución idónea para dotar de un lugar propio a los niños en la ciudad moderna. Hoy este concepto vuelve a resurgir al valorar la importancia del juego no estructurado en el desarrollo del niño y su vinculación con el entorno natural. El objetivo de esta investigación es revisar tres parques infantiles de aventura de aquellos años que son variantes del juego creativo del niño al aire libre. El parque de acción de Høje Gladsaxe (Dinamarca) es una reivindicación del lugar propio del niño realizado con restos y desechos de construcción. El parque de aventuras Lollard (Gran Bretaña) es una experiencia anárquica que se consideró un pequeño experimento de vida en democracia. Y el parque Robinson (Suiza) es una agrupación de actividades para el tiempo de ocio que pretendía el fomento de la comunidad. La metodología empleada es el análisis crítico y descriptivo de estos ejemplos para deducir tres acciones incidentales que puedan orientarnos en la significación de la arquitectura de lugares para la aventura. Se concluye señalando que el juego libre y creativo del niño en estos lugares nos puede aleccionar sobre las potencialidades de interaccionar con la tierra y sobre la atención y cuidado que le prestamos a la naturaleza. Estos lugares son un recurso que desencadena el aprendizaje tácito de acciones incidentales.
JUGAR LA CIUDAD. INFANCIA, JUEGO Y ESPACIO EN LAS IMÁGENES MANIFIESTO DEL TEAM 10
Authors: Albanelli Michele
Published: November 2023

El artículo indaga la capacidad del juego de producir espacio colectivo, con el objetivo de poner en evidencia su relevancia y potencial en el ámbito de la arquitectura. La lectura interpretativa de imágenes y diagramas producidos en el marco de las últimas tres ediciones del CIAM (1953, 1956 y 1959) por los integrantes del Team 10, Aldo van Eyck y Alison y Peter Smithson, sirve de premisa para colocar el objetivo mencionado en el contexto disciplinar. A través de una metodología de investigación histórico-comparativa que conecta los principales objetos de estudio con referentes y experiencias de diversos campos disciplinares (con particular énfasis en el ámbito de la educación), se procede en el análisis de las imágenes, identificando y proponiendo cuatro ejes conceptuales que puedan transferirse al quehacer contemporáneo de arquitectas y arquitectos: la celebración de lo cotidiano, el uso del lenguaje participativo de la fotografía urbana, la comprensión de la calle como escenario de la vida, el valor del juego en la producción del espacio colectivo. Bajo las premisas mencionadas, el texto abre la posibilidad y el debate hacia la integración del juego como índice de valoración y de proyección del espacio construido, poniendo en evidencia, a 70 años del CIAM (1953), la vigencia de las ideas del Team 10 y la relevancia disciplinar de las múltiples formas de hacer arquitectura que el grupo de vanguardia propone a través de su operar individual y colectivo.
A Unifying Framework for the Capacitated Vehicle Routing Problem Under Risk and Ambiguity
Authors: Ghosal Shubhechyya , Ho Chin Pang , Wiesemann Wolfram
Published: November 2023

New Framework Unifies Capacitated Vehicle Routing Problem Under Risk and Ambiguity

In the study titled “A Unifying Framework for the Capacitated Vehicle Routing Problem Under Risk and Ambiguity,” the authors propose a comprehensive and versatile framework that addresses the challenges posed by demand uncertainty in the capacitated vehicle routing problem (CVRP). This framework is able to consider and incorporate various risk measures, satisficing measures, and disutility functions, providing a unified approach to tackle different variants of the CVRP under uncertainty. By offering a unified treatment of the CVRP under risk and ambiguity, this framework enables decision makers to optimize routing decisions, accounting for the associated risks and uncertainties. One of the key advantages of this framework is its practicality for implementations. The authors demonstrate that an existing branch-and-cut algorithm can effectively solve all variants of the uncertainty-affected CVRP with minimal modifications. This scalability and adaptability make the framework applicable in practical settings.
DESIGUALDADES REGIONAIS E FUTEBOL: uma análise da primeira divisão do campeonato brasileiro entre 2003 e 2019
Authors: Cavalcante Luiz Ricardo
Published: November 2023

As desigualdades regionais que marcam o país refletem-se também no desempenho esportivo e, em particular, no futebol. Neste trabalho, empregam-se dados relativos ao desempenho das unidades da federação e das macrorregiões brasileiras na série A do campeonato brasileiro entre 2003 e 2019 para analisar essas desigualdades. Os resultados indicam que o desempenho das macrorregiões brasileiras mantém uma forte correlação com o produto interno bruto (PIB). No conjunto das 15 unidades da federação que estiveram representadas na série A do campeonato brasileiro também se observa, de modo geral, uma forte correlação entre desempenho e PIB. A presença de eventuais outliers (região Sul e Rio de Janeiro, por exemplo) sugere que fatores adicionais (como a tradição e o número de torcedores) podem contribuir para explicar o desempenho das regiões no campeonato brasileiro, embora dificuldades de aferição e sua colinearidade com outras variáveis imponham dificuldades adicionais para sua inclusão nos modelos.
UMA SISTEMÁTICA PARA CLASSIFICAÇÃO DE MODELOS DE NEGÓCIOS E ESTRATÉGIAS
Authors: Gomes Jaqueline , Okano Marcelo Tsuguio
Published: November 2023

O objetivo desta pesquisa é ampliar o conceito das relações entre modelos de negócios eestratégias de negócios, bem como desenvolver uma tabela de classificação entre assobreposições das relações. A metodologia utilizada foi abordagem qualitativa do tipoexploratória descritiva e o estudo de múltiplos casos foi aplicado para identificar assemelhanças e dissemelhanças nos modelos de negócios e suas estratégias para construção dosindicadores. Dentre os resultados pode-se destacar que as unificações das estratégiasindividuais de cada pilar do modelo de negócio, quando agrupadas representam as relaçõesentre modelos de negócios e estratégias de negócios de diversos sistemas produtivos
AMBIÊNCIA DOS TRABALHADORES QUE LIDAM COM A MORTE: uma investigação com Necrotomistas do Rio Grande do Norte
Authors: Dos Santos de Freitas Julia Maria , De Oliveira Agostinha Mafalda Barra , De Sousa Juliana Carvalho
Published: November 2023

Este estudo objetivou compreender as dimensões de contexto de trabalho, à luz da Psicodinâmica do Trabalho, na perspectiva dos necrotomistas. Trata-se de uma pesquisa qualitativa de caráter descritivo, realizada com sete necrotomistas de um Instituto Médico-Legal localizado no Rio Grande do Norte. Utilizou-se um roteiro semi-estruturado de perguntas baseado na Escala de Contexto de Trabalho (EACT). A estratégia utilizada para o tratamento dos dados adquiridos foi a análise de conteúdo. Com base nos dados encontrados no construto de contexto de trabalho, ambiente social   onde operam a organização, condições laborais e as relações socioprofissionais, identificou-se categorias que envolvem: falta de materiais e equipamentos adequados, insalubridade, divisão de tarefas, autogestão, sobrecarga, relações estritamente profissionais, diálogo aberto e conflitos internos. Espera-se que essa pesquisa se constitua como instrumento de discussão reflexivas e debates acerca da percepção e atribuição de sentido  ao trabalho para esse grupo ocupacional.
EROS E ERÓTICA COMO POÉTICA DE ENCANTAMENTO
Authors: Freire Machado Adilbênia
Published: November 2023

RESUMO: Este texto tem o intuito de dialogar partindo de filosofias africanas tecidas pelos saberes ancestrais femininos e pelo encantamento. Desse modo, o eros e a erótica apresentam-se como metodologias e movimentos ancestrais encantados de contracolonização, posto dialogarmos partindo de saberes orgânicos tecidos desde o centro da terra. Assim, dialogamos com sabedorias pautadas no movimento de pertencimento, de resistências e re-existências, de ética amorosa para potencialização de nossas vidas, de reconhecimento e reescrita de nossas histórias, cujo feminino é essa energia co-criadora que permite a própria vida. Movimentos afropindomâmicos de resistências ancestrais encantadas femininas.

PALAVRAS-CHAVE: Filosofias da Ancestralidade e do Encantamento; Ética Amorosa; Contracolonização; Sabedorias Afrorreferenciadas; Feminino.

 

ABSTRACT: This text intends to dialogue based on African philosophies woven by female ancestral knowledge and enchantment. In this way, eros and erotica are presented as methodologies and enchanted ancestral movements of counter-colonization, as we dialogue based on organic knowledge woven from the center of the earth. Thus, we dialogue with wisdom based on the movement of belonging, resistance and re-existence, of loving ethics to enhance our lives, of recognition and rewriting of our stories, whose feminine is this co-creating energy that allows life itself. Afropindomamic movements of female enchanted ancestral resistances.

KEYWORDS: Philosophies of Ancestry and Enchantment; Loving Ethics; Countercolonization; Afroreferenced Wisdoms; Feminine.
Do consentimento informado à tomada de decisão compartilhada e a urgência de sua implementação no contexto brasileiro
Authors: Carvalho Gonçalves Eler Kalline
Published: November 2023

O presente artigo expõe um panorama geral da Tomada de Decisão Compartilhada (TDC), considerada cada vez mais como a melhor forma para envolver os pacientes no processo de decisão sobre seus cuidados em saúde. Contudo, a despeito do amplo reconhecimento internacional, a TDC ainda não se encontra amplamente implementada na prática clínica brasileira, sendo o consentimento informado o modelo de tomada de decisão mais comumente adotado pelos profissionais de saúde. Assim, este trabalho, após esclarecer as definições em torno da TDC, apresenta instrumentos para sua aplicação e as razões pelas quais essa nova forma de tomar decisões deve ser preferível ao consentimento informado.
Digitalización de la comunicación y atención a personas LGBTIQ+: dos conflictos éticos emergentes para la Psicología en la Atención Primaria de Salud chilena
Authors: Pérez-Ayala Antonio
Published: November 2023

El artículo analiza los conflictos éticos detectados por Psicólogas/os en la Atención Primaria de Salud en Chile, centrando la descripción y análisis en los percibidos como emergentes, a través de un estudio cualitativo, tipo exploratorio-descriptivo. Dos fueron los principales conflictos identificados: a) resguardo de información sensible en ficha clínica electrónica y b) atención a personas LGBTIQ+ sin capacitación correspondiente. El estudio transparenta la importancia de visibilizar demandas incipientes en salud pública a través de las perspectivas de los propios profesionales, dotándoles de notoriedad para avanzar en su priorización y resolución. Explorar la dimensión ética es relevante para el ejercicio de la psicología contemporánea, porque da cuenta de las necesidades de la sociedad, permitiendo incluso anticiparse a ellas.
Heinz Janisch: Author–Austria
Authors: Janisch Heinz
Published: November 2023

Abstract: "Nothing is too small for literature."
Helga Bansch: Illustrator–Austria
Authors: Bansch Helga
Published: November 2023

Abstract: "A life without humor is unimaginable for me."
Bart Moeyaert: Author–Belgium
Authors: Moeyaert Bart
Published: November 2023

Abstract: "In this world, we are too often focused on the grand gestures and the loud voices. Instead, I prefer to consider one small morsel of thought at a time. The thoughts of a child are a splendid microcosm when you examine them under a microscope."
Marina Colasanti: Author–Brazil
Authors: Colasanti Marina
Published: November 2023

Abstract: "Wonderful tales are not, as so many people still believe, alienating and politically incorrect. On the contrary, they have a great social function, either by getting us familiarized with the symbolic language, the only one used by the unconscious, or by taking us out of our narrow reality, which makes us more permeable to diversity and allows empathy."
Nelson Cruz: Illustrator–Brazil
Authors: Cruz Nelson
Published: November 2023

Abstract: "Each story will act on my senses in a different way. As an illustrator, I must define the characters and settings so that the reader clearly understands and views the illustrations."
Sydney Smith: Illustrator–Canada
Authors: Smith Sydney
Published: November 2023

Abstract: "Illustrations can control how the story is read and can add weight to words or flip them upside down. There's a lot of power there."
Triunfo Arciniegas: Author–Colombia
Authors: Arciniegas Triunfo
Published: November 2023

Abstract: "Books, painting, and cinema have been a fundamental part of my education and my happiness in this no man's land. I have drunk of life, its most precious fruits. Writing is nothing more than giving back so many privileges."
Dora Oronti: Illustrator–Cyprus
Authors: Oronti Dora
Published: November 2023

Abstract: "In art classes, we are always faced with the question whether we are trying to teach future artists or shape future art lovers. I personally believe that these two views are not mutually exclusive.."
Affaf Tobbala: Author–Egypt
Authors: Tobbala Affaf
Published: November 2023

Abstract: "From my perspective, literature that exclusively appeals to children is no good. My respect for children means that I never underestimate them. We must provide them with real literature, a well-planned plot, well-developed characters, proper use of vocabulary."
Angeliki Darlasi: Author–Greece
Authors: Darlasi Angeliki
Published: November 2023

Abstract: "So I try to be honest, I cannot help but be honest and respectful when I write for children, hoping that my truths, my fears, my concerns, my dreams, my hopes, seen through their perspective in my writing might move them and connect with them even a little."
Beatrice Alemagna: Illustrator–Italy
Authors: Alemagna Beatrice
Published: November 2023

Abstract: "This is why I don't know how to illustrate texts that don't touch me personally and also why my books don't tend to resemble one another. I look back on each book as representing and reflecting a stage of my personal evolution."
Ryoji Arai: Illustrator–Japan
Authors: Arai Ryoji
Published: November 2023

Abstract: "The word 'world' could mean 'my world' or 'everyone's world.' I have had 'my world' ever since I was a child, and it is something that is important to me. I have learned that cherishing my world means I have got everyone else's world in my mind too. That is how I like to think about it anyway."
Thé Tjong-Khing: Illustrator–Netherlands
Authors: Tjong-Khing Thé
Published: November 2023

Abstract: "I draw all day; I'd be bored to death if I didn't. It is an exciting activity; you never know in advance how a drawing will turn out. The reason I've been able to keep it up for such a long time is that I don't always do the same thing."
Iwona Chmielewska: Illustrator–Poland
Authors: Chmielewska Iwona
Published: November 2023

Abstract: "In my opinion, the most important and moving children's books are the ones that have an equal amount of joy and sadness. Children need this tension coming from balancing these two emotions. They learn that real life is not only about fun and play but also about obstacles, sadness, sickness, or even death."
Repetition, Ageing and End of Life in Liudmila Ulitskaia's The Body of the Soul
Authors: Sutcliffe Benjamin M.
Published: November 2023

Abstract: Liudmila Ulitskaia's 2019 volume of stories, The Body of the Soul ( O tele dushi ), humanizes the end of life and counters harmful mythologies about ageing as well as dying in Russian culture. Ulitskaia, one of the nation's most prominent living authors, was the first woman to receive the Russian Booker Prize. The Body of the Soul repeats scenes and images from her previous fiction to explore how telesnost´ (corporeality) is its own cosmos of meaning. This contradicts assumptions dominating Russian culture over the past century and connects her older characters to the intelligentsia, which struggled to survive in the Soviet era and its aftermath. The Body of the Soul represents how the individual, often apolitical lives of older characters quietly contradict state ideals.
Suicidal ideation, plan, and attempt among men who have sex with men in Nepal: Findings from a cross-sectional study
Authors: Paudel Kiran , Gautam Kamal , Bhandari Prashamsa , Wickersham Jeffrey A. , Dhakal Manisha , Sharma Sanjay , Poudel Krishna C. , Ha Toan , Shrestha Roman
Published: November 2023

Men who have sex with men (MSM) are at increased risk for suicide, with a much higher prevalence of suicidality than the general population. While there is a growing interest in the identification of risk factors for suicidal behaviors globally, the understanding of the prevalence and risk factors for suicidal behaviors among MSM in the context of low- and middle-income countries is almost non-existent. Therefore, this study aimed to investigate suicidal ideation, plan, and attempts, and related factors among MSM in Nepal. A cross-sectional respondent driven survey was conducted on 250 MSM between October and December 2022. Bivariate and multivariable logistic regression was used to evaluate independent correlates of suicidal behaviors of MSM. Overall, the lifetime prevalence of suicidal ideation, plans, and attempts among MSM in this study were 42.4%, 31.2%, and 21.6%, respectively. MSM with depressive symptoms (aOR = 5.7, 95% CI = 2.4–14.1), advanced education (higher secondary and above; aOR = 2.9, 95% CI = 1.4–6.1), and smoking habit (aOR = 2.5, 95% CI = 1.2–5.3) were at increased risk for suicidal ideation. Similarly, those with depressive symptoms (aOR = 2.2, 95% CI = 1.1–4.8) and advanced education (aOR = 2.7, 95% CI = 1.2–5.7) were more likely to plan suicide, whereas young MSM were significantly more prone to attempting suicide (aOR = 2.7, 95% CI = 1.3–5.8). Interestingly, MSM with moderate to severe food insecurity were 2–3 times more likely to think about, plan, or attempt suicide (ideation: aOR = 3.5, 95% CI = 1.6–7.7; plan: aOR = 3.7, 95% CI = 1.6–8.3; attempt: aOR = 2.2, 95% CI = 1.1–4.6). The results suggest the importance of early assessment of suicidal behaviors among MSM and the need for tailored interventions to simultaneously address mental health problems and food insecurity to reduce suicide-related problems among Nepalese MSM.
Assessing risk factors for malaria and schistosomiasis among children in Misungwi, Tanzania, an area of co-endemicity: A mixed methods study
Authors: Duguay Claudia , Mosha Jacklin F. , Lukole Eliud , Mangalu Doris , Thickstun Charles , Mallya Elizabeth , Aziz Tatu , Feng Cindy , Protopopoff Natacha , Mosha Franklin , Manjurano Alphaxard , Krentel Alison , Kulkarni Manisha A.
Published: November 2023

Malaria and schistosomiasis are two major parasitic vector-borne diseases that are a particular threat to young children in Sub-Saharan Africa. In the present study, we investigated factors that are associated with malaria, schistosomiasis, and co-infection among school-aged children, using an explanatory sequential mixed-methods approach. A cross-sectional study was conducted in January 2022 in Misungwi, Tanzania, that sampled 1,122 children aged 5 to 14 years old for malaria and schistosomiasis infection. Mixed-effect logistic regression models were used to assess the association between infection prevalence or seroprevalence, and environmental determinants that create favorable conditions for vectors and parasites and social determinants that relate to disease exposure. Community mapping combined with direct field observations were conducted in August 2022 in three selected villages from the cross-sectional study to understand specific water use behaviors and to identify potential malaria mosquito larval breeding sites and freshwater snail habitat. The prevalence of malaria, seroprevalence of schistosomiasis, and co-infection in this study were 40.4%, 94.3%, and 38.1%, respectively. Individual-level factors emerged as the primary determinants driving the association with infection, with age (every one-year increase in age) and sex (boys vs girls) being statistically and positively associated with malaria, schistosomiasis, and co-infection (P<0.05 for all). Community maps identified many unimproved water sources in all three villages that were used by humans, cattle, or both. We found that children primarily fetched water, and that unprotected wells were dedicated for drinking water whereas ponds were dedicated for other domestic uses and cattle. Although not identified in the community maps, we found hand pumps in all three villages were not in use because of unpleasant taste and high cost. This study improves our understanding of individual, social and environmental factors that are associated with malaria, schistosomiasis, and co-infection, which can inform potential entry points for integrated disease prevention and control.