bluuebunny/crossref_metadata_2025 huggingface dataset:
Stevens–Johnson syndrome induced by toripalimab in a previously EGFR-TKI-treated advanced lung adenocarcinoma patient harboring EGFR mutations 19 del/T790M/C797S in trans and cis: a case report
Authors: Chen Yang , Hong Hanhan , Bao Shujun , Tang Hao
Published: November 2023

Background: The treatment paradigm for advanced non-small-cell lung cancer (NSCLC) is rapidly changing. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and anti-programmed death-1 (PD-1) antibodies have increasingly been incorporated into routine care for nearly all patients with NSCLC. Toripalimab was recently approved as the first-line treatment for advanced non-squamous NSCLC in combination with chemotherapy. Stevens–Johnson syndrome (SJS) is a rare but potentially fatal complication of TKI and anti-PD-1 therapy. We reported a case of SJS after sequential use of EGFR-TKIs and toripalimab in an NSCLC patient with EGFR mutations 19 del/T790M/C797S in trans and cis.

Case presentation: A 58-year-old man with stage IV NSCLC received gefitinib because next-generation sequencing (NGS) revealed an EGFR 19del, followed by osimertinib and pemetrexed with the emergence of EGFR T790M. Four EGFR mutations 19 del/T790M/C797S in trans and cis were detected after osimertinib resistance. The combination of toripalimab and docetaxel was administered as a third-line treatment. The patient developed SJS at 21 days, and toripalimab was discontinued. After treatment with methylprednisolone and prednisolone, the skin toxicity of the patient gradually decreased and eventually disappeared. The patient received osimertinib and anlotinib after recovery, and SJS has not recurred. The ongoing treatment is still effective and results in stable disease.

Conclusion: We reported the first case of SJS induced by toripalimab in a patient with lung adenocarcinoma harboring multiple EGFR mutations. The TKI treatment after SJS was well tolerated and effective.
PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes
Authors: Benzoni Patrizia , Da Dalt Lorenzo , Elia Noemi , Popolizio Vera , Cospito Alessandro , Giannetti Federica , Dell’Era Patrizia , Olesen Morten S. , Bucchi Annalisa , Baruscotti Mirko , Norata Giuseppe Danilo , Barbuti Andrea
Published: November 2023

Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide; however, the underlying causes of AF initiation are still poorly understood, particularly because currently available models do not allow in distinguishing the initial causes from maladaptive remodeling that induces and perpetuates AF. Lately, the genetic background has been proven to be important in the AF onset. iPSC-derived cardiomyocytes, being patient- and mutation-specific, may help solve this diatribe by showing the initial cell-autonomous changes underlying the development of the disease. Transcription factor paired-like homeodomain 2 (PITX2) has been identified as a key regulator of atrial development/differentiation, and the PITX2 genomic locus has the highest association with paroxysmal AF. PITX2 influences mitochondrial activity, and alterations in either its expression or function have been widely associated with AF. In this work, we investigate the activity of mitochondria in iPSC-derived atrial cardiomyocytes (aCMs) obtained from a young patient (24 years old) with paroxysmal AF, carrying a gain-of-function mutation in PITX2 (rs138163892) and from its isogenic control (CTRL) in which the heterozygous point mutation has been reverted to WT. PITX2 aCMs show a higher mitochondrial content, increased mitochondrial activity, and superoxide production under basal conditions when compared to CTRL aCMs. However, increasing mitochondrial workload by FCCP or β-adrenergic stimulation allows us to unmask mitochondrial defects in PITX2 aCMs, which are incapable of responding efficiently to the higher energy demand, determining ATP deficiency.
Hyperspectral estimation of chlorophyll content in jujube leaves: integration of derivative processing techniques and dimensionality reduction algorithms
Authors: Tuerxun Nigela , Zheng Jianghua , Wang Renjun , Wang Lei , Liu Liang
Published: November 2023

The leaf chlorophyll content (LCC) of vegetation is closely related to photosynthetic efficiency and biological activity. Jujube (Ziziphus jujuba Mill.) is a traditional economic forest tree species. Non-destructive monitoring of LCC of jujube is of great significance for guiding agroforestry production and promoting ecological environment protection in arid and semi-arid lands. Hyperspectral data is an important data source for LCC detection. However, hyperspectral data consists of a multitude of bands and contains extensive information. As a result, certain bands may exhibit high correlation, leading to redundant spectral information. This redundancy can distort LCC prediction results and reduce accuracy. Therefore, it is crucial to select appropriate preprocessing methods and employ effective data mining techniques when analyzing hyperspectral data. This study aims to evaluate the performance of hyperspectral data for estimating LCC of jujube trees by integrating different derivative processing techniques with different dimensionality reduction algorithms. Hyperspectral reflectance data were obtained through simulations using an invertible forest reflectance model (INFORM) and measurements from jujube tree canopies. The least absolute shrinkage and selection operator (LASSO) and elastic net (EN) were employed to identify the important bands in the original spectra (OS), first derivative spectra (FD), and second derivative spectra (SD). Support vector regression (SVR) was used to establish the estimation model. The results show that compared with full-spectrum modeling, LASSO and EN algorithms are effective methods for preventing overfitting in LCC machine learning estimation models for different spectral derivatives. The LASSO/EN-based estimation models constructed using FD and SD exhibited superior R2 compared to the OS. The important band of SD can best reveal the relevant information of jujube LCC, and SD-EN-SVR is the most ideal model in both the simulated dataset (R2 = 0.99, RMSE=0.61) and measured dataset (R2 = 0.89, RMSE=0.91). Our results provided a reference for rapid and non-destructive estimation of the LCC of agroforestry vegetation using canopy hyperspectral data.
Integrating spectral and image information for prediction of cottonseed vitality
Authors: Li Qingxu , Zhou Wanhuai , Zhang Hongzhou
Published: November 2023

Cotton plays a significant role in people’s lives, and cottonseeds serve as a vital assurance for successful cotton cultivation and production. Premium-quality cottonseeds can significantly enhance the germination rate of cottonseeds, resulting in increased cotton yields. The vitality of cottonseeds is a crucial metric that reflects the quality of the seeds. However, currently, the industry lacks a non-destructive method to directly assess cottonseed vitality without compromising the integrity of the seeds. To address this challenge, this study employed a hyperspectral imaging acquisition system to gather hyperspectral data on cottonseeds. This system enables the simultaneous collection of hyperspectral data from 25 cottonseeds. This study extracted spectral and image information from the hyperspectral data of cottonseeds to predict their vitality. SG, SNV, and MSC methods were utilized to preprocess the spectral data of cottonseeds. Following this preprocessing step, feature wavelength points of the cottonseeds were extracted using SPA and CARS algorithms. Subsequently, GLCM was employed to extract texture features from images corresponding to these feature wavelength points, including attributes such as Contrast, Correlation, Energy, and Entropy. Finally, the vitality of cottonseeds was predicted using PLSR, SVR, and a self-built 1D-CNN model. For spectral data analysis, the 1D-CNN model constructed after MSC+CARS preprocessing demonstrated the highest performance, achieving a test set correlation coefficient of 0.9214 and an RMSE of 0.7017. For image data analysis, the 1D-CNN model constructed after SG+CARS preprocessing outperformed the others, yielding a test set correlation coefficient of 0.8032 and an RMSE of 0.9683. In the case of fused spectral and image data, the 1D-CNN model built after SG+SPA preprocessing displayed the best performance, attaining a test set correlation coefficient of 0.9427 and an RMSE of 0.6872. These findings highlight the effectiveness of the 1D-CNN model and the fusion of spectral and image features for cottonseed vitality prediction. This research contributes significantly to the development of automated detection devices for assessing cottonseed vitality.
Cultural universality and specificity of teacher-student relationship: a qualitative study in Belgian, Chinese, and Italian primary school teachers
Authors: Xu Canmei , Huizinga Mariëtte , De Luca Giuseppe , Pollé Sophie , Liang Ruwen , Sankalaite Simona , Roorda Debora L. , Baeyens Dieter
Published: November 2023

Extensive evidence highlights the significant influence of dyadic, emotional teacher-student relationship (TSR) on students’ cognitive functioning, socio-emotional development, and overall well-being. However, it remains unclear whether the TSR construct and its manifestations can be generalized across cultures. This qualitative study investigated TSR among 60 primary school teachers in Belgium, China, and Italy (i.e., countries with varying positions on the collectivistic-individualistic continuum of culture). Through semi-structured interviews and metatheme analysis, the study examined the similarities and differences in TSR across these countries, revealing a nuanced and diverse picture in various cultural contexts. The findings align with the existing TSR model by including dimensions of closeness, conflict, and dependency, while also extending the model to identify additional dimensions such as authority, balance, distance, fairness, increasing student motivation, patience, and strictness. Regarding cultural perspective, teachers from these three countries exhibited similar conceptualizations of closeness, conflict, fairness, increasing student motivation, patience, and strictness, whereas the conceptualization of dependency, authority, balance, and distance may be influenced by (collectivistic versus individualistic) culture. Moreover, the manifestations of TSR varied across countries, highlighting the influence of cultural factors such as cultural norms, collectivistic versus individualistic values, and the perceived legitimacy of teacher authority. These findings shed light on the complexities of TSR across countries and emphasize the significance of culturally sensitive approaches in fostering positive TSR in education.
How much does HIV self-testing cost in low and middle income countries? A systematic review of evidence from economic studies
Authors: Empringham Brianna , Karellis Angela , Kashkary Abdulhameed , D’Silva Olivia , Carmona Sergio , Suarez Marta Fernandez , Addae Angelina , Pai Nitika Pant , Zwerling Alice Anne
Published: November 2023

Objectives

HIV self-testing (HIVST) has been proposed as an innovative strategy to diagnose human immunodeficiency virus (HIV). While HIVST offers the potential to broaden accessibility of early HIV diagnosis and treatment initiation, this testing strategy incurs additional cost and requires confirmatory testing and treatment. We have conducted the first systematic review to summarize the current economic literature for HIVST in low- and middle-income countries (LMICs).

Design

A search strategy was developed including key terms for HIV, self-testing and cost-effectiveness and was conducted in Medline and Embase databases. Studies were included that reported costs per outcome and included both cost-effectiveness and cost-utility outcome measures. The search strategy identified publications up until August 15, 2023 were included. Abstract and full text screening was conducted and a standardized data abstraction form was used for included studies. Costs are reported in USD, 2020.

Results

Our search strategy identified 536 total titles from the search strategy, which were screened down to 25 relevant studies that provided both cost and outcome data on HIVST. There was significant heterogeneity in the HIVST intervention, study population, costs and outcomes reported among included studies. Cost per person tested ranged from $1.09–155. Cost per case diagnosed ranged from $20–1,277. Cost-utility estimates ranged from cost-saving to $1846 per DALY averted. Higher cost-effectiveness estimates were associated with more expensive testing algorithms with increased support for linkage to care and post-test counseling.

Conclusion

All studies considered HIVST cost-effective although major drivers were identified included underlying HIV prevalence, testing cost and linkage to care. HIVST is likely to be cost-effective in a LMIC context, however policy makers should be aware of the drivers of cost-effectiveness when implementing HIVST programs as these underlying factors can impact the overall cost-effectiveness of HIVST.
Empowerment-based nutrition interventions on blood pressure: a randomized comparative effectiveness trial
Authors: Moreira-Rosário André , Ismael Shámila , Barreiros-Mota Inês , Morais Juliana , Rodrigues Catarina , Castela Inês , Mendes Inês Curvelo , Soares Maria Inês , da Costa Luís Soares , Oliveira Catarina Batista , Henriques Tiago , Pinto Patrícia , Pita Débora , de Oliveira Catarina Marques , Maciel Janaína , Serafim Thaina , Araújo João , Rocha Júlio César , Pestana Diogo , Silvestre Marta P. , Marques Cláudia , Faria Ana , Polonia Jorge , Calhau Conceição
Published: November 2023

Introduction

Empowerment lifestyle programs are needed to reduce the risk of hypertension. Our study compared the effectiveness of two empowerment-based approaches toward blood pressure (BP) reduction: salt reduction-specific program vs. healthy lifestyle general program.

Methods

Three hundred and eleven adults (median age of 44 years, IQR 34–54 years) were randomly assigned to a salt reduction (n = 147) or a healthy lifestyle program (n = 164). The outcome measures were urinary sodium (Na+) and potassium (K+) excretion, systolic (SBP) and diastolic (DBP) blood pressure, weight, and waist circumference.

Results

There were no significant differences in primary and secondary outcomes between the two program groups. When comparing each program to baseline, the program focused on salt reduction was effective in lowering BP following a 12-week intervention with a mean change of −2.5 mm Hg in SBP (95% CI, −4.1 to −0.8) and − 2.7 mm Hg in DBP (95% CI, −3.8 to −1.5) in the intention-to-treat (ITT) analysis. In the complete-case (CC) analysis, the mean change was −2.1 mm Hg in SBP (95% CI, −3.7 to −0.5) and − 2.3 mm Hg in DBP (95% CI, −3.4 to −1.1). This effect increases in subjects with high-normal BP or hypertension [SBP − 7.9 mm Hg (95% CI, −12.5 to −3.3); DBP − 7.3 mm Hg (95% CI, −10.2 to −4.4)]. The healthy lifestyle group also exhibited BP improvements after 12 weeks; however, the changes were less pronounced compared to the salt reduction group and were observed only for DBP [mean change of −1.5 mm Hg (95% CI, −2.6 to −0.4) in ITT analysis and − 1.4 mm Hg (95% CI, −2.4 to −0.3) in CC analysis, relative to baseline]. Overall, improvements in Na+/K+ ratio, weight, and Mediterranean diet adherence resulted in clinically significant SBP decreases. Importantly, BP reduction is attributed to improved dietary quality, rather than being solely linked to changes in the Na+/K+ ratio.

Conclusion

Salt-focused programs are effective public health tools mainly in managing individuals at high risk of hypertension. Nevertheless, in general, empowerment-based approaches are important strategies for lowering BP, by promoting health literacy that culminates in adherence to the Mediterranean diet and weight reduction.
Case report: Adjuvant therapy with toceranib for an incompletely resected renal cell carcinoma with suspected pulmonary metastasis in a dog
Authors: Lee Da-Eun , Nam Chang-Hoon , Yoon Hun-Young , Bae Kieun , Yoon Kyong-Ah , Kim Jung-Hyun
Published: November 2023

Primary renal neoplasia is rare in humans and dogs, with renal cell carcinoma (RCC) being the most common form of this cancer. As RCC is often diagnosed at an advanced stage, pulmonary metastasis is frequently observed. Tyrosine kinase inhibitors (TKIs) are the standard adjuvant treatments for metastatic RCC in humans. Similarly, in veterinary medicine, recent trials have employed TKIs for early-stage RCC patients who underwent complete surgical resection and showed no distant metastasis. However, the use of TKIs has not yet been reported commonly in cases of advanced RCC with metastasis. This case study presents the first clinical outcomes of TKI therapy in a dog with incompletely resected RCC and metastasis. A 5-year-old spayed female Chihuahua was referred to our hospital with a right renal mass and multiple pulmonary nodules suspected to be metastases. A portion of the renal mass was surgically removed, and histopathological examination revealed RCC with a high mitotic index. Adjuvant chemotherapy was administered, owing to incomplete resection with suspected pulmonary metastasis. An anticancer drug response prediction test was conducted using patient tissues. Since toceranib showed the most favorable responsiveness, it was selected as a therapeutic agent. Toceranib was orally administered at a dosage of 2.27 mg/kg every 48 h. Regular medical records for potential adverse effects were obtained, including systemic blood pressure, complete blood count, serum biochemical examination, and urinalysis. After 2 weeks of toceranib therapy, partial remission of pulmonary nodules continued for 2 months. The patient did not experience any adverse effects of the anticancer drug during the 4-month follow-up period. However, the patient died from an unidentified cause 6 months after the initial detection of the renal mass. This report describes the use of toceranib in dogs with RCC. In the present case, the patient showed an initial response to chemotherapy, and despite the presence of several poor prognostic factors, the dog survived beyond the expected 3-month lifespan to 6 months. Notably, no adverse events were observed during treatment.
Trends in E-Cigarette and Tobacco Cigarette Purchasing Behaviors by Youth in the United States, Canada, and England, 2017–2022
Authors: Roberson Avery , Cummings K. Michael , Reid Jessica L. , Burkhalter Robin , Gravely Shannon , East Katherine , Thrasher James F. , Hammond David
Published: November 2023

Objectives: This paper describes trends in youth e-cigarette (EC) and tobacco cigarette (TC) purchasing behaviors in Canada, England, and the United States (US) in relationship to changing minimum legal age (MLA) laws.

Methods: Data are from eight cross-sectional online surveys among national samples of 16- to 19-year-olds in Canada, England, and the US conducted from 2017 to 2022 (N = 104,467). Average wave percentage change in EC and TC purchasing prevalence and purchase locations were estimated using Joinpoint regressions.

Results: EC purchasing increased between 2017 and 2022, although the pattern of change differed by country. EC purchasing plateaued in 2019 for the US and in 2020 for Canada, while increasing through 2022 for England. TC purchasing declined sharply in the US, with purchasing from traditional retail locations declining, while purchasing from social sources increased. Vape shops were the most common location for EC purchasing, although declining in England and the US.

Conclusion: Trends in EC and TC purchasing trends in the US are consistent with the expected impact of the federal MLA law increasing the legal age to 21 years in December 2019.
Exploring the Use of Hydroxytyrosol and Some of Its Esters in Food-Grade Nanoemulsions: Establishing Connection between Structure and Efficiency
Authors: Freiría-Gándara Josefa , Martínez-Senra Tamara , Bravo-Díaz Carlos
Published: November 2023

The efficiency of HT and that of some of its hydrophobic derivatives and their distribution and effective concentrations were investigated in fish oil-in-water nanoemulsions. For this purpose, we carried out two sets of independent, but complementary, kinetic experiments in the same intact fish nanoemulsions. In one of them, we monitored the progress of lipid oxidation in intact nanoemulsions by monitoring the formation of conjugated dienes with time. In the second set of experiments, we determined the distributions and effective concentrations of HT and its derivatives in the same intact nanoemulsions as those employed in the oxidation experiments. Results show that the antioxidant efficiency is consistent with the “cut-off” effect—the efficiency of HT derivatives increases upon increasing their hydrophobicity up to the octyl derivative after which a further increase in the hydrophobicity decreases their efficiency. Results indicate that the effective interfacial concentration is the main factor controlling the efficiency of the antioxidants and that such efficiency strongly depends on the surfactant concentration and on the oil-to-water (o/w) ratio employed to prepare the nanoemulsions.
The Menopausal Transition: Is the Hair Follicle “Going through Menopause”?
Authors: Rinaldi Fabio , Trink Anna , Mondadori Giorgia , Giuliani Giammaria , Pinto Daniela
Published: November 2023

This article explores the link between menopause and changes in the hair follicle (HF) lifecycle, focusing on hormonal and metabolic dynamics. During menopause, hormonal fluctuations and aging can impact the HF, leading to phenomena such as thinning, loss of volume, and changes in hair texture. These changes are primarily attributed to a decrease in estrogen levels. However, not all women experience significant hair changes during menopause, and the extent of transformations can vary considerably from person to person, influenced by genetic factors, stress, diet, and other elements. Furthermore, menopause mirrors the aging process, affecting metabolism and blood flow to the HFs, influencing the availability of vital nutrients. The article also discusses the key role of energy metabolism in the HF lifecycle and the effect of hormones, particularly estrogens, on metabolic efficiency. The concept of a possible “menopause” clinically independent of menopause is introduced, related to changes in HF metabolism, emphasizing the importance of individual factors such as estrogen receptor responses, genetics, and last but not least, the microbiota in determining these dynamics.
Association between Diabetes and Levels of Micronutrients in Qatar—A Case–Control Study
Authors: Soliman Nada , Almishal Ruba , Elsayed Basant , Ahmed Ayaaz , Al-Amri Sara , Al-Kuwari Aisha , Al-Muhannadi Shaikha , Nadeer Muhammed , Chivese Tawanda
Published: November 2023

Objective: The objectives of this study were to investigate associations between micronutrient levels and diabetes and to explore the association in individuals with controlled and uncontrolled diabetes. Methods: A case–control study, matched on age and gender, was performed on participants with (cases) and without diabetes (controls), who were Qatari or long-term residents (≥15 years of residence). Participants with diabetes were divided into those with controlled and uncontrolled diabetes using an HbA1c cutoff of 7%. Levels of micronutrients were measured from serum and categorized into normal and abnormal levels. Results: A total of 1118 participants (374 cases and 744 controls) were included with a mean age of 41.7 years (SD 9.9), of whom 53.9% were female. Of those with diabetes, 229 had controlled diabetes and 145 had uncontrolled diabetes. Compared to those without diabetes, participants with diabetes had significantly lower mean magnesium (0.80 mmol/L (SD 0.07) vs. 0.84 mmol/L (SD 0.06), respectively, p < 0.001). Lower magnesium and iron were observed in participants with uncontrolled compared to participants with controlled diabetes. After multivariable logistic regression, diabetes was associated with hypomagnesemia (OR 3.2, 95% CI 3.4–213.9) and low iron (OR 1.49, 95% CI 1.03–2.15). Uncontrolled diabetes showed stronger odds of association with hypomagnesemia (OR 5.57, 95% CI 3.65–8.52). Conclusion: In an affluent setting in the MENA region, diabetes was associated with low magnesium and low iron, and this association was stronger in individuals with uncontrolled diabetes.
The Impact of Modern Anti-Diabetic Treatment on Endothelial Progenitor Cells
Authors: Altabas Velimir , Marinković Radošević Jelena , Špoljarec Lucija , Uremović Stella , Bulum Tomislav
Published: November 2023

Diabetes is one of the leading chronic diseases globally with a significant impact on mortality. This condition is associated with chronic microvascular and macrovascular complications caused by vascular damage. Recently, endothelial progenitor cells (EPCs) raised interest due to their regenerative properties. EPCs are mononuclear cells that are derived from different tissues. Circulating EPCs contribute to regenerating the vessel’s intima and restoring vascular function. The ability of EPCs to repair vascular damage depends on their number and functionality. Diabetic patients have a decreased circulating EPC count and impaired EPC function. This may at least partially explain the increased risk of diabetic complications, including the increased cardiovascular risk in these patients. Recent studies have confirmed that many currently available drugs with proven cardiovascular benefits have beneficial effects on EPC count and function. Among these drugs are also medications used to treat different types of diabetes. This manuscript aims to critically review currently available evidence about the ways anti-diabetic treatment affects EPC biology and to provide a broader context considering cardiovascular complications. The therapies that will be discussed include lifestyle adjustments, metformin, sulphonylureas, gut glucosidase inhibitors, thiazolidinediones, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide 1 receptor analogs, sodium-glucose transporter 2 inhibitors, and insulin.
The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma
Authors: Gołąbek Karolina , Hudy Dorota , Gaździcka Jadwiga , Miśkiewicz-Orczyk Katarzyna , Nowak-Chmura Magdalena , Asman Marek , Komosińska-Vassev Katarzyna , Ścierski Wojciech , Golusiński Wojciech , Misiołek Maciej , Strzelczyk Joanna Katarzyna
Published: November 2023

MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse the expression of the MDM2 target miRNA candidates (miR-3613-3p, miR-371b-5p and miR-3658) and the MDM2 gene in oral squamous cell carcinoma tumour and margin samples and their association with the selected socio-demographic and clinicopathological characteristics. The study group consisted of 50 patients. The miRNAs and MDM2 gene expression levels were assessed by qPCR. The expression analysis of the miRNAs showed the expression of only one of them, i.e., miR-3613-3p. We found no statistically significant differences in the miR-3613-3p expression in tumour samples compared to the margin samples. When analysing the effect of smoking on miR-3613-3p expression, we demonstrated a statistically significant difference between smokers and non-smokers. In addition, we showed an association between the miR-3613-3p expression level and some clinical parameters in tumour samples (T, N and G). Our study demonstrates that miR-3613-3p overexpression is involved in the tumour progression of OSCC. This indicates that miR-3613-3p possesses potential prognostic values.
First-Time Parents’ Bonding with Their Baby: A Longitudinal Study on Finnish Parents during the First Eight Months of Parenthood
Authors: Toivo Jessica , Tulivuo Noora , Kanzaki Mitsuko , Koivisto Anna-Maija , Kylmä Jari , Paavilainen Eija
Published: November 2023

Early positive bonding between parents and babies promotes the development of parenting skills and parents’ sensitivity to their infant’s needs. Positive bonding has been suggested to decrease the risk of maltreatment. There is less research into the differences between primiparae’s and their spouses’ bonding with their baby and changes in the parent-to-infant bonding during the first year of the baby’s life. The aim of this study was to describe bonding with one’s baby and related differences and changes within first-time parents. The data were collected from nine maternal health clinics in 2019–2021 in one city in Finland. The Mother-to-Infant Bonding Scale (MIBS) and the Edinburgh Postnatal Depression Scale (EPDS) were used. The data were collected during pregnancy (T1) and when the baby was aged 1–2 months (T2) and 6–8 months (T3). The questionnaire was completed separately by the primiparae (n = 81 at T1) and their spouses (n = 79 at T1). The findings demonstrated that both parents had positive feelings for their baby. The primiparae’s and their spouses’ MIBS scores were relatively low at T2 and T3. The change between time points or the difference in the parents’ bonding was not statistically significant when examining MIBS total scores. The present study identified a positive weak-to-moderate correlation between the MIBS and EPDS. This association was highlighted in the group of primiparae. The results of this study can be used to develop maternity and child health clinic services, and to promote parents’ equal growth in parenthood.
Valorisation of Madagascar’s Wildlife Trade and Wildlife Tourism: What Are the Conservation Benefits?
Authors: Carpenter Angus I. , Andreone Franco
Published: November 2023

Wildlife tourism and wildlife trade may appear juxtaposed, but are two, potentially aligning, income generators that could benefit conservation in developing countries. Utilising data sets collated from Madagascar’s Ministère du Tourisme and CITES, respectively, for the period 2007 to 2018, this study estimated levels of income from wildlife tourism and wildlife trade for Madagascar. Between 2007 and 2018, tourism reported yearly incomes ranging from a low of USD 1.4 million up to a high of USD 15.7 million. However, it was unclear what percentage of this figure flowed to benefit local communities. Alternatively, using reported networks for the live wildlife trade, the estimated economic value reaching collectors and/or intermediaries in Madagascar was USD 72,299.80 for the period 2007 to 2018. Both revenue generators operated within different geographical areas, with tourism opportunities presenting themselves to communities adjacent to national parks, while wildlife trade networks were not restricted to protected areas and operated sporadically across Madagascar. Hence, the economic benefits reached different Malagasy participants across the country. The management of both activities needs great care to ensure that environmental impacts and sustainability are core measures on any such activities. Whilst this study shines a light on economic values and novel perspectives regarding these two trade types, it also highlights knowledge gaps, thus indicating where much greater research attentions are required to allow a better understanding of the specific benefits and risks from engaging with both trade types for local Malagasy people and their environments.
Evaluation of the Effectiveness of Staphylococcus Phages in a Skincare Serum against Staphylococcus spp.
Authors: Pelyuntha Wattana , Yingkajorn Mingkwan , Narkpao Thamonwan , Saeaui Supanida , Promkuljan Khemapsorn , Vongkamjan Kitiya
Published: November 2023

The emergence of multidrug-resistant (MDR) Staphylococcus spp. has resulted in the reduced use of antibiotics in many skincare cosmetic products. Alternative treatments using natural bioactive compounds and chemical agents can be replaced. However, these compounds have induced negative side effects among users and are not environmentally friendly. Phage therapy is an alternative to antibiotics for the treatment of specific pathogenic bacteria including Staphylococcus spp., without harmful effects on human skin cells and microflora. Phages can be potentially used in cosmetic products. The direct application of phage-based cosmetic products on skin can reduce the chance of skin infection caused by pathogenic Staphylococcus spp. In the present work, we isolated 17 Staphylococcus phages from sewage and soil samples. Phage A1 showed the highest lytic ability at 50% (B1 profile), covering 13 tested Staphylococcus isolates including Staphylococcus aureus (SA), methicillin-resistant S. aureus (MRSA), S. capitis (SC), and S. epidermidis (SE). Phage A1 reduced the representative S. aureus ATCC 25923 and S. capitis SC1 by 2.0 ± 0.1 and 4.1 ± 0.3 log units at a multiplicity of infection (MOI) of 104 and by 4.2 ± 0.2 and 4.4 ± 0.5 log units at a MOI of 105 after 6 h of post-phage treatment. The transmission electron microscope revealed that phage A1 was classified in the order Caudovirales of the family Myoviridae based on its appearance. Phage A1 showed optimal survival in the presence of a 0.125% (v/v) solidant DMH suspension after 3 h of post-treatment. Under a phage skincare serum formulation, the titers of phage A1 were reduced by 0.46 and 0.85 log units after storage at 4 and 25 °C, whereas a reduction of 2.96 log units was also observed after storage at 37° for 90 days. This study provides strong evidence for the effectiveness of phage application in cosmetic skincare serum for the treatment of skin diseases caused by MDR and pathogenic Staphylococcus spp. The concept of this study could be advantageous for cosmetic and/or cosmeceutical industries searching for new bioactive ingredients for cosmetic/cosmeceutical products.
A 150-Year Debate over Surnames vs. Patronymics in Iceland
Authors: Willson Kendra
Published: November 2023

Iceland stands out in today’s Europe due to the fact that most Icelanders use patronymics rather than surnames. However, a small percentage of Icelanders do have surnames inherited in a fixed form. The first surnames were adopted in the 17th and 18th centuries. In the late 19th and early 20th centuries, increasing numbers of Icelanders were taking up surnames, often Danicized or Latinized versions of Icelandic patronymics or place names. The practice became controversial with the rise of the independence movement, which was closely connected to linguistic purism. The use of surnames in Iceland has been debated since the 19th century. Whereas the other Nordic countries introduced legislation requiring citizens to have surnames, Iceland went in the opposite direction, forbidding new surnames starting in 1925. However, the surnames that were already in use were allowed to remain in circulation. This created an inequality which has haunted Icelandic name law discourse since. Having a surname in Iceland has often been linked with social prestige, and surnames have been perceived as a limited good. Since the 1990s, the fraction of Icelanders with surnames has increased through immigration and some liberalizations in the rules regarding the inheritance of existing Icelandic surnames. In the name of gender equity, surnames can be inherited along any line, not only patrilineal. Since 1996, immigrants seeking Icelandic citizenship are no longer required to change their names, and their children can inherit their surnames. The category of millinöfn (middle name), surname-like names that are not inflected for gender, was introduced in the 1996 law; some Icelanders with millinöfn use them as surnames in daily life even if they officially have patronymics. Despite the expansion in eligibility to take surnames, the basic principle that no new Icelandic surnames are allowed remains in the law and remains a point of contention. Many of the same themes—individual freedom vs. the preservation of cultural heritage, national vs. international orientation, gender equity—have recurred in the discourse over more than a century, reframed in the context of contemporary cultural values at any given time.
Study of the Chemical Composition of Carica papaya L. Seed Oils of Various Geographic Origins
Authors: Goriainov Sergey , Orlova Svetlana , Nikitina Elena , Vandishev Viktor , Ivlev Vasiliy , Esparza Cesar , Vasil’ev Vasiliy , Platonov Evgeniy , Sheremeta Anzhelika , Kalabin Gennadiy
Published: November 2023

The papaya plant (Carica papaya L.) is tree-like fruit plant cultivated throughout the tropics and subtropics. The aim of this study was to compare the physicochemical properties, fatty acid, sterols, and triterpenic alcohols composition of Carica papaya L. seed oils grown in a typical geographical location and Carica papaya L. seed oils grown in an untypical geographical location in greenhouse conditions (Saratov Region, Russia). The oils were extracted from the seeds of Carica papaya L. fruits collected in Kenya, the Dominican Republic, Angola, Ghana, and Brazil, as well as from the seeds of fruit plants grown in a similar environment (Russian Federation, Saratov). Parameters such as the oil yield, refractive index, peroxide value, iodine value, saponification value, and acid value of the extracted Carica papaya L. seed oils were determined. The qualitative and quantitative chemical compositions of the seed oils were determined by a combination of mass spectrometry and NMR spectroscopy. The profiles as well as the content of fatty acids, sterols, triterpenic alcohols, and benzyl isothiocyanate were established. The saponifiable fraction of the oils is mainly represented by triglycerides (98.7–99.4%), while di-(0.4–1.1%) and monoglycerides (0.1–0.3%) are also present but in smaller amounts. The content of sterols and triterpene alcohols was (537.5–918.2) mg/100 g of oil (0.54–0.92%), and up to 75% of the fraction was represented by β-sitosterol (55.9–66.7%) and its saturated analogue-sitostanol (11.0–15.7%). The physicochemical properties and the fatty acid, sterol, and triterpenic alcohol composition of seed oils from Carica papaya L. fruits, cultivated in Russia, is in the quantitative range of other samples, which suggests that Carica papaya L. can be grown in Russia for obtaining the seed oil.
Comprehensive Evaluation Model and Methodology for Offshore Wind Farm Collection and Transmission Systems
Authors: Song Yuanyuan , Chang Xiqiang , Wang Haiyun
Published: November 2023

With the gradual development of offshore wind farms toward large-scale and long-distance trends, economically efficient methods for correcting and transmitting offshore wind energy have garnered increasing attention. The rational and effective evaluation of offshore wind power collection and transmission methods has become an urgent issue. To address this, a comprehensive evaluation model for collection and transmission systems, considering factors such as network losses, lifecycle costs, and reliability, was established. This proposed model was applied to multiple sets of typical collection and transmission scenarios, utilizing an improved TOPSIS comprehensive evaluation method based on dynamic combination weighting to achieve the comprehensive optimization of collection and transmission schemes. Case studies have validated the feasibility of the comprehensive evaluation model. The results indicate that with an increase in offshore distance, the AC/DC collection and transmission system is superior to the all-AC collection and transmission system, and the all-DC collection system exhibits potential cost advantages.
Mucosal Immunity to Gut Fungi in Health and Inflammatory Bowel Disease
Authors: Carlson Sean L. , Mathew Liya , Savage Michael , Kok Klaartje , Lindsay James O. , Munro Carol A. , McCarthy Neil E.
Published: November 2023

The gut microbiome is a diverse microbial community composed of bacteria, viruses, and fungi that plays a major role in human health and disease. Dysregulation of these gut organisms in a genetically susceptible host is fundamental to the pathogenesis of inflammatory bowel disease (IBD). While bacterial dysbiosis has been a predominant focus of research for many years, there is growing recognition that fungal interactions with the host immune system are an important driver of gut inflammation. Candida albicans is likely the most studied fungus in the context of IBD, being a near universal gut commensal in humans and also a major barrier-invasive pathogen. There is emerging evidence that intra-strain variation in C. albicans virulence factors exerts a critical influence on IBD pathophysiology. In this review, we describe the immunological impacts of variations in C. lbicans colonisation, morphology, genetics, and proteomics in IBD, as well as the clinical and therapeutic implications.
The Indeterminacy of Social Meaning Linked to ‘Mexico’ and ‘Texas’ Spanish: Examining Monoglossic Language Ideologies among Heritage and L2 Spanish Listeners
Authors: Regan Brendan , Martinez Jazmyn L.
Published: November 2023

This study examines how implied speaker nationality, which serves as a proxy for bilingual/monolingual status, influences social perception and linguistic evaluation. A modified matched-guise experiment was created with the speech of eight bilingual U.S. Spanish speakers from Texas talking about family traditions; the speech stimuli remained the same, but the social information provided about the speakers–whether they were said to be from Mexico (implied monolingual) or from Texas (implied bilingual)–varied. Based on 140 listeners’ responses (77 L2 Spanish listeners, 63 heritage Spanish listeners), quantitative analyses found that overall listeners evaluated ‘Mexico’ voices as more able to teach Spanish than ‘Texas’ voices. However, only heritage listeners perceived ‘Mexico’ voices as being of higher socioeconomic status and of more positive social affect than ‘Texas’ voices. Qualitative comments similarly found that heritage listeners evaluated ‘Mexico’ voices more favorably in speech quality and confidence than ‘Texas’ voices. The implications are twofold: (i) the social information of implied monolingualism/bilingualism influences listeners’ social perceptions of a speaker, reflecting monoglossic language ideologies; and (ii) there exists indeterminacy between language and social meaning that varies based on differences in lived experiences between L2 and heritage Spanish listeners. Extending on previous findings of indeterminacy between linguistic variants and meaning, the current study shows this also applies to (implied) language varieties, demonstrating the role of language ideologies in mediating social perception.
Cº realizations along the left edge across English and Spanish
Authors: Villa-García Julio
Published: November 2023

This paper investigates the lexicalization of the complementizer that/que in English and Spanish varieties in different contexts along the left edge of the clause. This is performed through discussion of a range of constructions traditionally attributed to the CP domain/left periphery, primarily (but not only) in certain embedded clauses. The ubiquity of that/que, that is, the lexical realization of that/que in subordinating environments, exclamative clauses, interrogative contexts, and subjunctive clauses, amongst others, sheds light not only on the characterization of the relevant constructions but also on the make-up of the left edge of the clause. The fact that such realizations can be obligatory, optional, or, on occasion, impossible, sometimes depending on the variety in question, furthers our understanding of head lexicalizations while contributing to macro and microvariation studies in syntactic theory. In so doing, this paper paves the way for holistic investigations devoted to complementizer realization in the head position of different left-edge-related constructions and in different linguistic varieties.
Effects of Search Strategies on Collective Problem-Solving
Authors: Cao Shun
Published: November 2023

In today’s dynamic and complex social environments, collaborative human groups play a critical role in addressing a wide range of real-world challenges. Collective problem-solving, the process of finding solutions through the collaboration of individuals, has become imperative in addressing scientific and technical problems. This paper develops an agent-based model to investigate the influence of different search strategies (simple local search, random search, and adaptive search) on the performance of collective problem-solving under various conditions. The research involves simulations on various problem spaces and considers distinct search errors. Results show that random search initially outperforms other strategies when the search errors are relatively small, yet it is surpassed by adaptive search in the long term when the search errors increase. A simple local search consistently performs the worst among the three strategies. Furthermore, the findings regarding adaptive search reveal that the speed of adaptation in adaptive search varies across problem spaces and search error levels, emphasizing the importance of context-specific parameterization in adaptive search strategies. Lastly, the values of Ps=0.9 and Pf=0.2 obtained through human subject experiments in adaptive search appear to be a favorable choice across various scenarios in this simulation work, particularly for complex problems entailing substantial search errors. This research contributes to a deeper understanding of the effectiveness of search strategies in complex environments, providing insights for improving collaborative problem-solving processes in real-world applications.
On Bilevel Monotone Inclusion and Variational Inequality Problems
Authors: Ofem Austine Efut , Abuchu Jacob Ashiwere , Nabwey Hossam A. , Ugwunnadi Godwin Chidi , Narain Ojen Kumar
Published: November 2023

In this article, the problem of solving a strongly monotone variational inequality problem over the solution set of a monotone inclusion problem in the setting of real Hilbert spaces is considered. To solve this problem, two methods, which are improvements and modifications of the Tseng splitting method, and projection and contraction methods, are presented. These methods are equipped with inertial terms to improve their speed of convergence. The strong convergence results of the suggested methods are proved under some standard assumptions on the control parameters. Also, strong convergence results are achieved without prior knowledge of the operator norm. Finally, the main results of this research are applied to solve bilevel variational inequality problems, convex minimization problems, and image recovery problems. Some numerical experiments to show the efficiency of our methods are conducted.