bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-regulating arousal via pupil-based biofeedback
Authors: Meissner Sarah Nadine , Bächinger Marc , Kikkert Sanne , Imhof Jenny , Missura Silvia , Carro Dominguez Manuel , Wenderoth Nicole
Published: October 2023

The brain’s arousal state is controlled by several neuromodulatory nuclei known to substantially influence cognition and mental well-being. Here we investigate whether human participants can gain volitional control of their arousal state using a pupil-based biofeedback approach. Our approach inverts a mechanism suggested by previous literature that links activity of the locus coeruleus, one of the key regulators of central arousal and pupil dynamics. We show that pupil-based biofeedback enables participants to acquire volitional control of pupil size. Applying pupil self-regulation systematically modulates activity of the locus coeruleus and other brainstem structures involved in arousal control. Furthermore, it modulates cardiovascular measures such as heart rate, and behavioural and psychophysiological responses during an oddball task. We provide evidence that pupil-based biofeedback makes the brain’s arousal system accessible to volitional control, a finding that has tremendous potential for translation to behavioural and clinical applications across various domains, including stress-related and anxiety disorders.
A systematic review and meta-analysis of the global prevalence and determinants of COVID-19 vaccine acceptance and uptake in people living with HIV
Authors: Sulaiman Sahabi Kabir , Musa Muhammad Sale , Tsiga-Ahmed Fatimah Isma’il , Sulaiman Abdulwahab Kabir , Bako Abdulaziz Tijjani
Published: October 2023

People living with HIV (PLHIV) are at higher risk of poor outcomes of SARS-CoV-2 infection. Here we report the pooled prevalence of COVID-19 vaccine acceptance/uptake and determinants among this vulnerable population of PLHIV based on a systematic review and meta-analysis of studies published by 25 August 2023. Among the 54 included studies (N = 167,485 participants), 53 (N = 166,455) provided data on vaccine acceptance rate, while 27 (N = 150,926) provided uptake data. The global prevalences of COVID-19 vaccine acceptance and uptake were 67.0% and 56.6%, respectively. Acceptance and uptake rates were 86.6% and 90.1% for the European Region, 74.9% and 71.6% for the Region of the Americas, 62.3% and 78.9% for the South-East Asian Region, 64.6% and 19.3% for the Eastern Mediterranean Region, 58.0% and 35.5% for the African Region, and 57.4% and 44.0% for the Western Pacific Region. The acceptance rate increased from 65.9% in 2020 to 71.0% in 2022, and the uptake rate increased from 55.9% in 2021 to 58.1% in 2022. Men, PLHIV aged ≥40 years and those who had recently received the influenza vaccine were more likely to accept and receive the COVID-19 vaccine. Factors associated with lower uptake included Black race, other races (Latinx/Hispanic/mixed race), low education level and being unemployed. Vaccine-related factors associated with higher acceptance included belief in vaccine effectiveness, vaccine trust, perceived high susceptibility to SARS-CoV-2 infection and fear of potential COVID-19 effect in PLHIV. Sustained efforts and targeted interventions are needed to reduce regional disparities in COVID-19 vaccine uptake among PLHIV.
Time lag effect on malaria transmission dynamics in an Amazonian Colombian municipality and importance for early warning systems
Authors: Gonzalez-Daza William , Vivero-Gómez Rafael Jose , Altamiranda-Saavedra Mariano , Muylaert Renata L. , Landeiro Victor Lemes
Published: October 2023

Malaria remains a significant public health problem worldwide, particularly in low-income regions with limited access to healthcare. Despite the use of antimalarial drugs, transmission remains an issue in Colombia, especially among indigenous populations in remote areas. In this study, we used an SIR Ross MacDonald model that considered land use change, temperature, and precipitation to analyze eco epidemiological parameters and the impact of time lags on malaria transmission in La Pedrera—Amazonas municipality. We found changes in land use between 2007 and 2020, with increases in forested areas, urban infrastructure and water edges resulting in a constant increase in mosquito carrying capacity. Temperature and precipitation variables exhibited a fluctuating pattern that corresponded to rainy and dry seasons, respectively and a marked influence of the El Niño climatic phenomenon. Our findings suggest that elevated precipitation and temperature increase malaria infection risk in the following 2 months. The risk is influenced by the secondary vegetation and urban infrastructure near primary forest formation or water body edges. These results may help public health officials and policymakers develop effective malaria control strategies by monitoring precipitation, temperature, and land use variables to flag high-risk areas and critical periods, considering the time lag effect.
Comparative effectiveness of two intravenous immunoglobulin products in children with Kawasaki disease, a nationwide cohort study
Authors: Kuo Ni-Chun , Lin Ching-Heng , Lin Ming-Chih
Published: October 2023

Kawasaki Disease (KD) is the most common acquired pediatric heart disease in the developed world. Rapid infusion of high-dose intravenous immunoglobulin is the standard therapy. Different manufacturing processes of IVIG may influence their efficacy. This study aims to conduct a head to head comparison of two IVIGs, TBSF and Privigen, from a nationwide perspective. The main data source was the National Health Insurance Research Database (NHIRD) of Taiwan. A total of 3368 KD cases involving children under 2 years of age were enrolled from January 2015 to November 2020. The primary endpoint was IVIG resistance, which we defined as the total amount exceeding 26 g in one admission. The secondary endpoints encompassed two distinct criteria: coronary involvement, which was defined as the prolonged use of aspirin or anti-coagulation agents between 180 and 360 days after the index date, and recurrence, which was defined as readmission for IVIG therapy occurring more than 30 days after previous KD index day and continuing until the end of the follow-up period. Privigen demonstrated a lower IVIG resistance rate at 9.4% in comparison to TBSF, which exhibited a rate of 9.7% (odds ratio 0.72, 95% CI 0.52–0.99). Privigen had a lower odds of coronary involvement (odds ratio 0.38, 95% CI 0.18–0.82). There is no difference in recurrence rate (odds ratio 0.60, 95% CI 0.22–1.68). Privigen might have a lower rate of IVIG resistance and reduced coronary artery involvement. The discrepancy may be due to the concentration, the stabilizers, or the source of plasma. Further investigation is needed to compare the effectiveness of different IVIGs in the large randomized controlled clinical trial.
Network meta-analysis of comparative efficacy and safety of intubation devices in children
Authors: Ming Yu , Chu Shujuan , Yang Kai , Zhang Zhao , Wu Zhouyang
Published: October 2023

To evaluate the comparative efficacy and safety of different intubation devices on intubation outcomes in pediatric intubation. We identified relevant studies from previous meta-analyses and literature retrieval in PubMed, EMBASE, and Cochrane Library. The primary outcome was the first-pass success (FPS), and the secondary outcome included the time to intubation (TTI) and the risk of local complications (LC). Network meta-analysis was performed using STATA 14.0. Twenty-three randomized comparative trials (RCTs) including 12 devices were included. Compared with Macintosh, Airtraq (odds ratio [OR] = 13.05, 95% confidence interval [CI] = 4.68 to 36.38), Miller (OR = 4.77, 95%CI = 1.32 to 17.22), Glidescope (OR = 2.76, 95%CrI = 1.60 to 4.75) and McGrath (OR = 4.61, 95%CI = 1.18 to 17.99) obtained higher PFS. Meanwhile, Airtraq was superior to Glidescope (OR = 0.21, 95%CI = 0.07 to 0.65) for PFS. For TTI, Canada was superior to other intubation devices, as well as CMAC was superior to TruViewEVO2, Glidescope, and StorzDCI. Airtraq lowered the risk of LC compared with Macintosh and Pentax but there was no statistical difference between Airtraq and KingVision. Airtraq may be the optimal option for FPS, Canada for TTI, and KingVision for LC in pediatric intubation.
Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization
Authors: Yu Feiyan , Yang Yang , Wu Dongchao , Chang Minjing , Han Chong , Wang Qianqian , Li Yi , He Dongning
Published: October 2023

Inflammatory bowel disease (IBD) and periodontitis are reported to be closely associated; however, whether there is a causal association between them remains unclear. To explore the existence of this causality, this study applied a bidirectional two-sample Mendelian randomization (MR). The genetic variants were obtained from the summary statistics of genome-wide association studies of IBD, including its subtypes CD and UC, and periodontitis. 175, 148, 113, and six single-nucleotide polymorphisms were selected as instrumental variables for IBD, CD, UC, and periodontitis, respectively. In MR analysis, random-effects inverse-variance weighted was used as the primary method, and weighted median and MR Egger regression were applied as the complementary method. A series of sensitivity analyses were also conducted to ensure the reliability of the results. None of these analyses found a significant effect of genetically proxied IBD and its subtypes on periodontitis, and vice versa. Subsequent sensitivity analyses did not detect any horizontal pleiotropy and heterogeneity. Caution should be exerted when it comes to clinical relevance and further studies are needed to clarify the relationship between IBD and periodontitis.
Combining ultrasonic guided wave and low-frequency electromagnetic technology for defect detection in high-temperature Cr–Ni alloy furnace tubes
Authors: Du Chenyang , Li Xiaowei , Liu Chang , Song Ce , Yuan Jun , Xin Yanchao
Published: October 2023

Cracking furnaces, operating under high temperatures and in a hydrocarbon medium, subject their tubes to complex stresses such as internal pressure, self-weight, fatigue, and thermal shock during start-up and shutdown. As a result, these furnace tubes frequently experience failures characterized by cracks and corrosion perforation. The high-temperature environment, constantly evolving structure of the tubes, and the close arrangement of the cracks within the tube box hinder detecting the cracks using conventional single-detection methods is challenging. This paper breaks through the limitations of the traditional single detection method and studies the effectiveness of the combination of ultrasonic-guided wave and low-frequency electromagnetic detection methods. The experiment was carried out by deliberately making cracks and thinning defects caused by corrosion on the cracking furnace tube of Cr35Ni45Nb after two years of service. The experimental results show that the ultrasonic guided wave detection technology can quickly detect the defects running through the whole furnace tube and effectively identify the manufacturing defects. On the other hand, low-frequency electromagnetic detection makes it possible to scan suspicious local defects and make qualitative and quantitative analyses of defect signals. The combination of ultrasonic guided wave and low-frequency electromagnetic detection can realize the rapid location and comprehensive qualitative and quantitative analysis of furnace tube defects, thus making up for the defects missed detection caused by the lack of effectiveness of single detection and the resulting safety problems. The research results have great popularization value in practical engineering applications.
Role of sex in lung cancer risk prediction based on single low-dose chest computed tomography
Authors: Simon Judit , Mikhael Peter , Tahir Ismail , Graur Alexander , Ringer Stefan , Fata Amanda , Jeffrey Yang Chi-Fu , Shepard Jo-Anne , Jacobson Francine , Barzilay Regina , Sequist Lecia V. , Pace Lydia E. , Fintelmann Florian J.
Published: October 2023

A validated open-source deep-learning algorithm called Sybil can accurately predict long-term lung cancer risk from a single low-dose chest computed tomography (LDCT). However, Sybil was trained on a majority-male cohort. Use of artificial intelligence algorithms trained on imbalanced cohorts may lead to inequitable outcomes in real-world settings. We aimed to study whether Sybil predicts lung cancer risk equally regardless of sex. We analyzed 10,573 LDCTs from 6127 consecutive lung cancer screening participants across a health system between 2015 and 2021. Sybil achieved AUCs of 0.89 (95% CI: 0.85–0.93) for females and 0.89 (95% CI: 0.85–0.94) for males at 1 year, p = 0.92. At 6 years, the AUC was 0.87 (95% CI: 0.83–0.93) for females and 0.79 (95% CI: 0.72–0.86) for males, p = 0.01. In conclusion, Sybil can accurately predict future lung cancer risk in females and males in a real-world setting and performs better in females than in males for predicting 6-year lung cancer risk.
Copper and chromium removal from industrial sludge by a biosurfactant-based washing agent and subsequent recovery by iron oxide nanoparticles
Authors: Subsanguan Tipsuda , Jungcharoen Phoomipat , Khondee Nichakorn , Buachan Pantita , Abeyrathne Buddhika Prabath , Nuengchamnong Nitra , Pranudta Antika , Wannapaiboon Suttipong , Luepromchai Ekawan
Published: October 2023

Industrial wastewater treatment generates sludge with high concentrations of metals and coagulants, which can cause environmental problems. This study developed a sequential sludge washing and metal recovery process for industrial sludge containing > 4500 mg/kg Cu and > 5000 mg/kg Cr. The washing agent was formulated by mixing glycolipid, lipopeptide, and phospholipid biosurfactants from Weissella cibaria PN3 and Brevibacterium casei NK8 with a chelating agent, ethylenediaminetetraacetic acid (EDTA). These biosurfactants contained various functional groups for capturing metals. The optimized formulation by the central composite design had low surface tension and contained relatively small micelles. Comparable Cu and Cr removal efficiencies of 37.8% and 38.4%, respectively, were obtained after washing the sludge by shaking with a sonication process at a 1:4 solid-to-liquid ratio. The zeta potential analysis indicated the bonding of metal ions on the surface of biosurfactant micelles. When 100 g/L iron oxide nanoparticles were applied to the washing agent without pH adjustment, 83% Cu and 100% Cr were recovered. In addition, X-ray diffraction and X-ray absorption spectroscopy of the nanoparticles showed the oxidation of nanoparticles, the reduction of Cr(V) to the less toxic Cr(III), and the absorption of Cu. The recovered metals could be further recycled, which will be beneficial for the circular economy.
Feedback between megathrust earthquake cycle and plate convergence
Authors: Martin de Blas Juan , Iaffaldano Giampiero , Tassara Andrés , Melnick Daniel
Published: October 2023

Over million years, convergence between the Nazca and South America tectonic plates results in Andean orogeny. Over decades/centuries, it fuels the earthquake cycle of the Andean megathrust. It is well recognised that, over the geologically-long term of million years, Andean orogeny feeds back onto plate convergence rates, generating temporal changes documented throughout the Neogene. In contrast, no feedback mechanism operated over the geologically-short term by the earthquake cycle is currently contemplated. In fact, it is commonly assumed that the rates of contemporary convergence, which are accurately measured via geodesy, remain steady during the megathrust earthquake cycle. Here we investigate whether the contemporary Nazca/South America plate motion varies over year-/decade-long periods in response to megathrust stress variations associated with the earthquake cycle. We focus on the decade preceding the three largest and most recent $${\varvec{M_w > 8}}$$

M
w

>
8

earthquakes (2010 $${\varvec{M_w = 8.8}}$$

M
w

=
8.8

Maule, 2014 $${\varvec{M_w = 8.1}}$$

M
w

=
8.1

Iquique, 2015 $${\varvec{M_w = 8.3}}$$

M
w

=
8.3

Illapel), and find slowdowns of both Nazca and South America whole-plate motions that exceed the impact of data uncertainty or noise. We show that the torque variations required upon Nazca and South America to generate the slowdowns are consistent with that arising from the buildup of interseismic stress preceding the earthquakes.
Proteomic profile of naturally released extracellular vesicles secreted from Leptospira interrogans serovar Pomona in response to temperature and osmotic stresses
Authors: Techawiwattanaboon Teerasit , Phanchamnan Eakalak , Iadsee Nutta , Makjaroen Jiradej , Pisitkun Trairak , Patarakul Kanitha
Published: October 2023

Bacterial extracellular vesicles (EVs) are generally formed by pinching off outer membrane leaflets while simultaneously releasing multiple active molecules into the external environment. In this study, we aimed to identify the protein cargo of leptospiral EVs released from intact leptospires grown under three different conditions: EMJH medium at 30 °C, temperature shifted to 37 °C, and physiologic osmolarity (EMJH medium with 120 mM NaCl). The naturally released EVs observed under transmission electron microscopy were spherical in shape with an approximate diameter of 80–100 nm. Quantitative proteomics and bioinformatic analysis indicated that the EVs were formed primarily from the outer membrane and the cytoplasm. The main functional COG categories of proteins carried in leptospiral EVs might be involved in cell growth, survival and adaptation, and pathogenicity. Relative to their abundance in EVs grown in EMJH medium at 30 °C, 39 and 69 proteins exhibited significant changes in response to the temperature shift and the osmotic change, respectively. During exposure to both stresses, Leptospira secreted several multifunctional proteins via EVs, while preserving certain virulence proteins within whole cells. Therefore, leptospiral EVs may serve as a decoy structure for host responses, whereas some virulence factors necessary for direct interaction with the host environment are reserved in leptospiral cells. This knowledge will be useful for understanding the pathogenesis of leptospirosis and developing as one of vaccine platforms against leptospirosis in the future.
The use of a Mamdani-type fuzzy model for assessing the performance of a boom stabilization systems in a field sprayer
Authors: Kaliniewicz Zdzisław , Szczyglak Piotr , Lipiński Adam , Markowski Piotr , Lipiński Seweryn
Published: October 2023

Fuzzy logic models are increasingly used to control simple and complex devices, as well as entire operating systems. In this study, a fuzzy logic model was applied to assess the performance a boom stabilization system in a field sprayer. The model was tested on a field sprayer with a trapezoid system for stabilizing the sprayer boom with a length of 21 m. Measuring cables for registering the displacement of the boom's terminal segments (right and left) in the vertical and horizontal plane were installed on the sprayer. The field sprayer was connected to a tractor. The model was based on two linguistic variables: "absolute displacement of the boom's terminal segments" and "boom stability index". It was assumed that the sprayer boom was stable when the displacement of the boom's terminal segments did not exceed 0.25% of boom length. The study demonstrated that the proposed model can be reliably used to assess boom stability in real time (during field operations). The time required to achieve boom stability was more than 2.5 times shorter in the vertical than in the horizontal plane, which can be attributed mainly to the structure of the stabilization system. The proposed model is universal, and it can be applied to evaluate other boom stabilization systems in field sprayers.
Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Authors: Mandal Kamal , Wicaksono Gianina , Yu Clinton , Adams Jarrett J. , Hoopmann Michael R. , Temple William C. , Izgutdina Adila , Escobar Bonell Patiño , Gorelik Maryna , Ihling Christian H. , Nix Matthew A. , Naik Akul , Xie William H. , Hübner Juwita , Rollins Lisa A. , Reid Sandy M. , Ramos Emilio , Kasap Corynn , Steri Veronica , Serrano Juan Antonio Camara , Salangsang Fernando , Phojanakong Paul , McMillan Melanie , Gavallos Victor , Leavitt Andrew D. , Logan Aaron C. , Rooney Cliona M. , Eyquem Justin , Sinz Andrea , Huang Benjamin J. , Stieglitz Elliot , Smith Catherine C. , Moritz Robert L. , Sidhu Sachdev S. , Huang Lan , Wiita Arun P.
Published: October 2023

Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis that tumor cells express cancer-specific surface protein conformations that are invisible to standard target discovery pipelines evaluating gene or protein expression, and these conformations can be identified and immunotherapeutically targeted. We term this strategy integrating cross-linking mass spectrometry with glycoprotein surface capture ‘structural surfaceomics’. As a proof of principle, we apply this technology to acute myeloid leukemia (AML), a hematologic malignancy with dismal outcomes and no known optimal immunotherapy target. We identify the activated conformation of integrin β2 as a structurally defined, widely expressed AML-specific target. We develop and characterize recombinant antibodies to this protein conformation and show that chimeric antigen receptor T cells eliminate AML cells and patient-derived xenografts without notable toxicity toward normal hematopoietic cells. Our findings validate an AML conformation-specific target antigen and demonstrate a tool kit for applying these strategies more broadly.
Global shortfalls of knowledge on anuran tadpoles
Authors: Vera Candioti Florencia , Baldo Diego , Grosjean Stéphane , Pereyra Martín O. , Nori Javier
Published: October 2023

Despite the amount of data on different aspects of biodiversity, such as species distributions, taxonomy, or phylogenetics, there are still significant gaps and biases in the available information. This is particularly true for life history traits, with fragmentary data for most taxa, especially those with complex life cycles. Anurans (frogs and toads) show larval (premetamorphic) stages that are in general radically decoupled from adult forms in most biological aspects. Our understanding of this group is highly uneven, as the main wide-scope investigations focus on adult specimens and larval stages remain unknown for a significant part of the anuran tree. The main purpose of this work was to estimate the extent of knowledge gaps regarding the diversity of tadpoles, interpret their biological and geographical patterns, and discuss possible explanations and implications for other large-scale analyses. Our findings show that more than half of the anuran species described to date still lack information on their embryonic/larval stages. Furthermore, knowledge varies among taxonomic groups, larval ecomorphological guilds, and world ecoregions. Description percentages generally decrease in lineages with a higher proportion of species known or suspected to have endotrophic development. Also, geographic areas with the highest levels of ignorance in larval biology (Tropical Andes and New Guinea) coincide with the highest diversity of endotrophic guilds. Among exotrophic larvae, generalized lentic-lotic tadpoles have the widest distribution and levels of knowledge, whereas specialized lotic, fossorial, and terrestrial forms are more taxonomically and geographically restricted. Further large-scale analyses on tadpole biology are crucial for their impact in varied scientific disciplines including anuran conservation. At a conceptual level, the discussion of the anuran biphasic life cycle is pertinent in the context of shortfalls of biodiversity knowledge and their interrelationships.
N-doped molybdenum oxide quantum dots as fluorescent probes for the quantitative detection of copper ions in environmental samples
Authors: Ma Ting , Liu Mingzhu , Sun Jingran , Wu Jin , Zhao Zunquan , Bai Jialei , Fang Yanjun , Jin Xiaoyong
Published: October 2023

A novel, sensitive, and selective fluorescence sensor based on N-doped Mo oxide quantum dots (N-MoOx QDs) was fabricated for the detection of Cu2+ ions in water.
Construction of a MAPbBr3/BiFeO3 Z-scheme heterojunction with enhanced piezo-photocatalytic performance
Authors: Zhou Dan-Yang , Zhou Yi-Ou , Fang Su-Yan , Pan Guang-Yu , He Xiong , Xu Mei-Ling , Liu Fu-Tian , Li Kui
Published: October 2023

Based on the large visible light absorption coefficient and tunable band gap of MAPbBr3, weakening the strong photogenerated carrier recombination tendency to exploit the CO2 reduction potential is a worthy research topic.
Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice
Authors: Guo Shasha , Shi Yuxuan , Xu Anan , Wang Yuefei , Xu Ping
Published: October 2023

LBTE inhibits airway hyper-reactivity and inflammation in OVA-induced asthmatic mice. Gut microbiota mediates prevention of LBTE in OVA-induced asthmatic mice.
Multifunctional liposomes Co-encapsulating epigallocatechin-3-gallate (EGCG) and miRNA for atherosclerosis lesion elimination
Authors: Li Dandan , Liu Danni , Wang Yaoqi , Sun Qi , Sun Ran , Zhang Jie , Hong Xiaoxuan , Huo Ran , Zhang Shuang , Cui Chunying
Published: October 2023

A liposome co-loaded with an antioxidant and anti-inflammatory drug EGCG and a lipid-efflux-promoting gene miR-223 is constructed to eliminate AS plaques effectively, and provide a novel strategy for the safe and efficient management of AS.
Self-powered broadband photodetection enabled by facile CVD-grown MoS2/GaN heterostructures
Authors: Liang Bor-Wei , Chang Wen-Hao , Huang Chun-Sheng , Huang You-Jia , Chen Jyun-Hong , Li Kai-Shin , Simbulan Kristan Bryan , Kumar Harshvardhan , Su Ching-Yuan , Kuan Chieh-Hsiung , Lan Yann-Wen
Published: October 2023

This study shows a facile wafer-scale MoS2/ GaN heterojunction photodetectors array with self-powered broadband photoresponse (404 nm to 808 nm). The outstanding performance is attributed to the direct CVD growth of MoS2, resulting in low lattice mismatch with GaN.
Strategic sampling with stochastic surface walking for machine learning force fields in iron's bcc–hcp phase transitions
Authors: Wang Fang , Yang Zhi , Li Fenglian , Shao Jian-Li , Xu Li-Chun
Published: October 2023

A machine learning force field for predicting the bcc–hcp phase transitions of iron, demonstrates good performance with DFT calculations, offering new insights and approaches for materials science and solid-state physics research.
Electrospun VO2/carbon fibers for aqueous zinc-ion batteries
Authors: Yin Liying , Xu Zenglong , Yang Guangxu , Guo Fuhai , Guo Wenhui , Zhao Songfang , Yang Shuhua
Published: October 2023

The electrospun VO2/carbon fibers (VO2@CPAN) consisted of 3D carbon fibers and flake-like VO2 is developed, showing high specific capacity, improved rate capacity, and superior cycle performance for aqueous Zn-ion batteries.
Synthesis and evaluation of potent (iso)ellipticine-based inhibitors of MYLK4 accessed via expeditious synthesis from isoquinolin-5-ol
Authors: Lee Szu , Chao Min-Wu , Wu Yi-Wen , Hsu Chia-Min , Lin Tony Eight , Hsu Kai-Cheng , Pan Shiow-Lin , Lee Hsueh-Yun
Published: October 2023

The K2S2O8-mediated generation of p-iminoquinone contributed to the regioselective substitution of isoquinolin-5,8-dione.
Bioinformatics-guided discovery of biaryl-linked lasso peptides
Authors: Saad Hamada , Majer Thomas , Bhattarai Keshab , Lampe Sarah , Nguyen Dinh T. , Kramer Markus , Straetener Jan , Brötz-Oesterhelt Heike , Mitchell Douglas A. , Gross Harald
Published: October 2023

Genome mining enabled the discovery of a series of unique lasso peptides. They contain a P450-mediated C–N-based biarylic crosslink at the lasso ring and can in addition bear a unique sulfonium residue.
Observation of parallel intersystem crossing and charge transfer-state dynamics in [Fe(bpy)3]2+ from ultrafast 2D electronic spectroscopy
Authors: Lee Angela , Son Minjung , Deegbey Mawuli , Woodhouse Matthew D. , Hart Stephanie M. , Beissel Hayden F. , Cesana Paul T. , Jakubikova Elena , McCusker James K. , Schlau-Cohen Gabriela S.
Published: October 2023

Ultrafast two-dimensional electronic spectroscopy, in conjunction with DFT calculations, revealed parallel pathways for the earliest stages of charge transfer-state evolution in the prototypical first-row transition metal complex [Fe(bpy)3]2+.
Integration of plasma and electrocatalysis to synthesize cyclohexanone oxime under ambient conditions using air as a nitrogen source
Authors: Jia Shunhan , Tan Xingxing , Wu Limin , Ma Xiaodong , Zhang Libing , Feng Jiaqi , Xu Liang , Song Xinning , Zhu Qinggong , Kang Xinchen , Sun Xiaofu , Han Buxing
Published: October 2023

We propose a sustainable strategy to efficiently synthesize cyclohexanone oxime using air as the N source. The process is carried out through an integrated strategy including plasma-assisted air-to-NOx and co-electrolysis of NOx and cyclohexanone.
Anti-Arrhenius behavior of electron transfer reactions in molecular dimers
Authors: Lin Neo , Mani Tomoyasu
Published: October 2023

The degree of torsional hindrance can significantly contribute to anti-Arrhenius behavior of charge recombination, wherein recombination rates decrease as temperature increases.
Gold-catalyzed alkenylation and arylation of phosphorothioates
Authors: Urvashi  , Mishra Sampoorna , Patil Nitin T.
Published: October 2023

Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides.
Photochemical halogen-bonding assisted carbothiophosphorylation reactions of alkenyl and 1,3-dienyl bromides
Authors: Piedra Helena F. , Gebler Victoria , Valdés Carlos , Plaza Manuel
Published: October 2023

The photochemical halogen-bonding assisted alkenylation and dienylation of phosphoro(di)thioate diesters under batch and continuous flow is disclosed. Mechanistic studies support the formation of the halogen-bonding complex and the radical pathway.
Correction: Prussian blue and its analogues as functional template materials: control of derived structure compositions and morphologies
Authors: Bornamehr Behnoosh , Presser Volker , Zarbin Aldo J. G. , Yamauchi Yusuke , Husmann Samantha
Published: October 2023

Correction for ‘Prussian blue and its analogues as functional template materials: control of derived structure compositions and morphologies’ by Behnoosh Bornamehr et al., J. Mater. Chem. A, 2023, 11, 10473–10492, https://doi.org/10.1039/D2TA09501G.
Determining an Effective Language Sample Elicitation Strategy for Early Language Learners Who Speak Using Augmentative and Alternative Communication
Authors: Trevino Courtney T. , Lund Emily A.
Published: October 2023

Purpose:

This study evaluates three different language sample elicitation strategies to determine a valid elicitation strategy for early language learners who speak using augmentative and alternative communication (AAC).

Method:

Ten children who speak using AAC participated in this study. Language samples were elicited from each participant using three strategies: the Communication and Symbolic Behavior Scales (CSBS), a generic play-based elicitation strategy, and automatic data logging. Samples were transcribed and coded. Additionally, each participant's school speech-language pathologist completed a Communication Matrix. Data from coded language samples were correlated with Communication Matrix results to determine the elicitation strategy that yielded the most valid language sample in comparison to Communication Matrix results.

Results:

Both the CSBS and the play-based strategy yielded clinically relevant information. Because the log lacked communicative context, resulting data from the log was limited. An analysis of variance revealed significant differences in the amount of information elicited from each elicitation strategy. The CSBS repeatedly elicited the most data, followed by the play-based strategy and then the log. Generic play-based strategy results yielded the most correlations with Communication Matrix data.

Conclusions:

This preliminary data suggest that the play-based elicitation strategy elicited the most valid language sample when compared to the Communication Matrix from early language learners who speak using AAC. Additionally, results suggest that the CSBS may be an effective tool to measure the limits of this population's expressive language abilities.
The CMB Cold Spot as predicted by foregrounds around nearby galaxies
Authors: Lambas Diego Garcia , Hansen Frode K. , Toscano Facundo , Luparello Heliana E. , Boero Ezequiel F.
Published: October 2023

Context. The non-Gaussian Cold Spot surrounded by its hot ring is one of the most striking features of the cosmic microwave background (CMB) and has generated significant attention in the literature. It has been speculated that either new physics or the Integrated Sachs-Wolfe effect induced by the presence of a cosmic void at relatively high redshift could account for the observations.

Aims. Here, we investigate if the newly discovered systematic decrease in the CMB temperature in the neighbourhood of nearby galaxies may create such a strong temperature depression. In particular, we note that the largest galaxy group complex in the local Universe, the Eridanus super-group with its neighbouring groups, is in the Cold Spot area. Our goal is to analyse observational galaxy data to characterise the neighbourhood of the Cold Spot, explore the properties of these galaxies, and thereby make a prediction of the galaxy induced CMB temperature decrement in this region.

Methods. We used the Planck SMICA maps, and as foreground tracers, galaxies from the publicly available observational catalogues: 2MRS, 6dF, and HIPASS, which include information on redshifts, positions, magnitudes, and other astrophysical characteristics. We applied previously explored mean temperature profile shapes to model the expected temperature decrement from the galaxies in the Cold Spot area.

Results. Even after correcting for the mean low temperature of the Cold Spot region, we find that the temperature decrement around galaxies is significantly stronger than the mean decrement in other parts of the sky. We discuss whether this could be attributed to the fact that the Cold Spot area coincides with one of the regions populated by the most HI deficient galaxies. Modeling the foreground temperature profile that is mainly associated with spiral galaxies in this location, we find a particularly strong temperature decrement due to the presence of the late-type overabundant largest group complex in the nearby universe. A Cold Spot shape that largely overlaps with the CMB Cold Spot is observed.

Conclusions. We conclude that the coincidence of the only nearby spiral-rich group complex located in the Cold Spot region, and the success of the modelling performed, adds strong evidence to the existence of a local extragalactic foreground that may account for the observed temperature depression, alleviating the tension with the Gaussian field that is otherwise expected in the CMB.
Mise en place de projets industriels pour des élèves ingénieurs
Authors: Laffont Jacques , Lengagne Sébastien
Published: October 2023

Ce document présente l’enseignement de projet dispensé aux étudiants de niveau Bac+4 et Bac+5 du département Génie Electrique de Polytech Clermont. Ces activités de projet représentent plus de deux cents heures par étudiant et sont menées en lien avec des clients industriels, des tuteurs industriels et académiques dans le but de développer les compétences des étudiants afin de les préparer au métier d’ingénieur.
Développement d’une interface utilisateur interactive pour l’enseignement du traitement de signal
Authors: Smagin N. , Chehami L.
Published: October 2023

Dans l'apprentissage de traitement du signal, les connaissances formelles (théorèmes et lois) se fait généralement en lien avec la pédagogie dans le souci de mieux les faire appréhender et assimiler par les étudiants. Ces concepts fondamentaux sont parfois difficiles à enseigner dans le schéma classique des exposés magistraux, et des travaux dirigés. Il est parfois alors nécessaire d'illustrer ces ressources théoriques à l'aide des animations et des schémas plus interactifs. De plus, la pédagogie moderne nous impose de revoir nos pratiques d'enseignement et nous oblige de plus en plus à utiliser des outils informatiques pour enseigner. Il est donc essentiel de s'adapter à ce mode d'enseignement qui privilégie les technologies récentes pour mieux préparer nos étudiants à leur futur emploi. C'est dans cette logique que nous avons initié depuis septembre 2022 l'élaboration d'une interface graphique sur le traitement de signal destiné aux étudiants en master et aux doctorants. Ayant comme support Matlab, cette dernière offre la possibilité d'acquérir, de traiter et de consolider les concepts de base en traitement du signal.
Retour d’expérience sur l’utilisation d’un jumeau numérique pour l’enseignement de l’automatisme
Authors: Gellot François , Lecasse Stéphane , Riera Bernard , Philippot Alexandre
Published: October 2023

Dans le cadre d’un enseignement progressif de l’automatisme, nous verrons dans cet article qu’il est intéressant d’utiliser un jumeau numérique d’un système réel pour aller vers la programmation de systèmes complexes industriels. Nous utilisons pour cela trois logiciels Siemens communiquant ensemble à savoir NX MCD, pour le jumeau numérique, PLC SIM Advanced pour le simulateur d’automate et TIA Portal pour la partie programmation. Les TP utilisant le jumeau numérique pour réaliser la commande d’un poste de notre cellule flexible ayant été réalisés par deux profils d’élèves ingénieurs en apprentissage de niveau bac+4, un questionnaire leur a été soumis afin de récupérer leur retour et leur perception du jumeau numérique. Globalement les retours sont bons même s’il faut distinguer dans l‘analyse du questionnaire les profils automaticiens, des profils plus maintenance.
Instrumentation à bas coût pour l’électrotechnique en TBT
Authors: Le Bras Yannick
Published: October 2023

Avec le développement des énergies renouvelables, de nombreuses formations sont amenées à proposer des enseignements pratiques en électrotechnique pour, par exemple, étudier des panneaux photovoltaïques ou des moteurs électriques. Ainsi, dans le cadre du nouveau BUT Mesures Physiques parcours Mesures et Analyses Environnementales, des enseignants sont chargés de monter de nouveaux travaux pratiques d’électrotechnique sans pour autant utiliser de salle spécialisée en basse tension avec du matériel onéreux. On présente dans cet article l’instrumentation développée pour des travaux pratiques d’électrotechnique en très basse tension et mise en œuvre à l’ENSIM et à l’IUT du Mans (LE MANS Université). Ce matériel est notamment mis en œuvre pour étudier des moteurs électriques.
Retour d’expérience de l’utilisation de jumeaux numériques dans la formation d’ingénieurs autour de l'industrie 4.0
Authors: Saddem Ramla
Published: October 2023

L'industrie 4.0, caractérisée par l'intégration des technologies de l'information et de la communication (TIC) dans les processus de production, a conduit à l'émergence des jumeaux numériques comme une solution clé pour améliorer la productivité et l'efficacité. Les jumeaux numériques sont des répliques virtuelles des objets ou des processus du monde réel qui permettent une analyse approfondie, une optimisation et une meilleure compréhension des systèmes industriels. La formation des ingénieurs aux défis de l'industrie 4.0 devient donc essentielle pour assurer la compétitivité et l'innovation dans le monde de demain. Dans cet article, nous présentons un retour d’expérience sur l'utilisation des jumeaux numériques pour la formation des futurs ingénieurs aux défis de l'industrie 4.0. Les utilisateurs sont deux groupes d’étudiants, en deuxième année de cycle ingénieur, un groupe en formation initiale et un groupe en formation continue, au sein de l’École d'ingénieurs en Sciences Industrielles et Numérique (EiSINe) de l’Université de Reims Champagne-Ardenne.
IEC 61499 : Retour d’expérience sur l’application de la norme en pédagogie
Authors: Parant Alexandre , Lecasse Stéphane , Gellot François , Philippot Alexandre
Published: October 2023

L’objectif de cet enseignement est de présenter à des étudiants la norme IEC 61499 et son utilisation dans le développement et l’implémentation du système de commande d’un système automatisé de production. Cet enseignement inclut un cours magistral présentant les concepts de la norme IEC 61499 et les différences avec les langages de la norme IEC 61131-3 traditionnellement utilisés dans les enseignements de l’automatisme. Il incorpore également une séance de travaux pratiques où le logiciel EcoStruxure Automation Expert est utilisé pour développer l’application de commande et où le logiciel Factory I/O est utilisé pour simuler des systèmes automatisés de production. Un retour d’expérience est présenté dans cette communication sur l’enseignement de la norme IEC 61499.
ProGreSS 4.0 : Une plateforme mêlant recherche et enseignement
Authors: Marangé Pascale , Aubry Alexis , Derigent William , Levrat Eric , Duverger Loic , Pannequin Rémi , Collot Eric , Lombard Muriel , Masschelein Olivier , Mayo Jennifer , Metzger Jean-Luc , Nartz Olivier
Published: October 2023

L’industrie 4.0 pose de nouvelles problématiques de recherche qui doivent être abordées également en enseignement. Dans ce contexte, il est nécessaire de sensibiliser les étudiants à ces problématiques via des plateformes intégrant les derniers concepts abordés en recherche et aux dernières technologies aussi proches que possible de la réalité industrielle voire en avance de phase. Les problématiques traitées via cette plateforme portent sur le développement durable, plus particulièrement de régénération et l’utilisation des technologies de l’industrie 4.0. L’objectif de ce papier est de présenter d’une part une plateforme nommée ProGreSS 4.0 en cours de réalisation et d’autre part de montrer le transfert des travaux de recherche en enseignement. Cette plateforme est basée à l’AIP de Lorraine et elle est réalisée conjointement entre les ingénieurs du CRAN et de l’AIPL.
Mise en pratique de compétences en robotique à partir d'un robot réel et de sa simulation
Authors: Lengagne Sébastien
Published: October 2023

Dans le cadre des cours portant sur les robots manipulateurs, l'approche pédagogique s'est focalisée sur l'application à un système réel lors de séances de travaux pratiques et à la réalisation de challenge en autonomie en utilisant un environnement de simulation proche de l'environnement réel. La motivation de cette méthode est d'assurer la maitrise des concepts de base, (transformation entre repères, ...) lors de séance encadrée pour inciter les étudiants à appliquer ces concepts de manière autonome dans une application plus complexe.
The relation between apparent and true water colour for pond water
Authors: Prokop Kubinova Tereza , Brozová Katerina , Kyncl Miroslav
Published: October 2023

The colour of the water can be considered as apparent colour, which is determined by the amount of suspended matter such as clay, phytoplankton and colloidal particles, and true colour, which is the proportion of suspended matter passing through a membrane filter of pore size the 0.45 μm. This study aimed to investigate the apparent and true water colour of pond water and evaluate the impact of filtration on water colour. Using a spectrophotometer, measurements and analyses were conducted on pond water samples. The results of the study showed that filtration can significantly affect the water colour, with a clear difference observed between the apparent and true water colour. The research findings provide a deeper understanding of the factors that influence water colour.
Reliability of the grouting of tendons under consideration of uncertainties under on-site conditions
Authors: Muron Vlastimil , Klusacek Ladislav
Published: October 2023

This paper contributes to the body of knowledge from German research work Deutscher Ausschuss für Stahlbeton and from author’s experiences, to improve the reliability of cable ducts grouting. The complete and reliable filling of post-tensioned tendons with grout is necessary to protect the prestressing steel against corrosion and for bond between prestressing steel and the concrete structure, which is in both limit states applied. Diagnostics of bridges built in the last century showed the cases of faulty grouting of cable ducts. These faults are cause of corrosion prestressing steel often. Based on these diagnostics, bridges are after 35 to 70 years of service life demolished, although service life of these bridges was to 100 years declared. In the studied research work were investigated the effects of individual components, procedures and conditions of the grout and results of grouting investigated. Tests have been performed both on the experiment cable ducts and the real structures. Based on this paper, certain principles have been recommended that aim to prevent grouting faults and to improve the reliability of the grouting. In these recommendations are suggestions of controls of grouting included.
Interface parameters between strengthened flat slab and concrete overlay
Authors: Ceres Daniel , Gajdosova Katarina
Published: October 2023

This article aims to the comparison of different parameters for defining the interface characteristics between flat slab without transverse reinforcement and reinforced concrete overlay in non-linear analysis. The input parameters for the interface are stiffness, tensile strength, friction coefficient and cohesion. These coefficients represent uncertainties in non-linear modelling. Non-linear model was developed in ATENA 3D software and simulates punching shear of flat slab without shear reinforcement strengthened by concrete overlay. Two types of interfaces are considered: without reinforcement crossing the interface and with shear reinforcement crossing the interface. Parametric study shows, how different values of interface parameters influence the final punching shear capacity of representative model. Numerical models will be used as a prediction for experimental results of specimens.
The influence of the mass moisture content of the masonry on the choice of insulation system for historic buildings
Authors: Hutkai Kristian , Katunsky Dusan
Published: October 2023

When discussing the energy efficiency of historic structures, increased humidity of the perimeter wall is a crucial problem. It greatly affects the choice of insulation system, because if the drying of the structure becomes impossible, permanently increased humidity of the structure can lead to serious damage to the perimeter structure. The contribution focuses on the interior insulation design of historical structures with various types of elevated humidity with the use of dynamic simulation techniques to evaluate the appropriateness of several thermal insulation materials. The degree of drying and the thermal-humidity response of the buildings after the historic wall has been insulated from the inside will be assessed based on the findings of HAM simulations.