bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES
Authors: Ragino Yu. I. , Striukova E. V. , Murashov I. S. , Polonskaya Ya. V. , Volkov A. M. , Kashtanova E. V. , Kurguzov A. V. , Chernjavskii A. M.
Published: September 2018

Objective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1, monocyticchemoattractant protein type 1, MCP-1, lipoprotein (a), LP (a), adhesive molecules sVCAM-1, asymmetric dimethylarginin, ADMA, homocysteine), inflammation (interleukins, IL-6, IL - 8, C-reactive protein, CRP) and with unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis.

Material and methods. In 93 men with coronary atherosclerosis without acute coronary syndrome, blood coagulation factors concentrations (factor II, factor VII, factor XII, antithrombin III) were studied in the blood with goal to find their associations with biomarkers of endothelial dysfunction (endothelin 1, MCP-1, LP(a), adhesion molecules sVCAM-1, ADMA, homocysteine), of inflammation (IL-6, IL-8, CRP) and with the presence of unstable plaques in the coronary arteries.

Results. In men with unstable atherosclerotic plaques in the coronary arteries, the blood levels of factor VII and factor XII were 1.3 and 1.3 times higher, respectively, compared to men who had stable plaques in the coronary arteries. Correlation links between the blood levels of factor II and factor XII and the presence of unstable atherosclerotic plaques in the coronary arteries (r=0.239 and r=0.250, p <0.05, respectively) have been revealed, as well as between coagulation factors and blood levels of LP(a), sVCAM-1, IL-6 and CRP. Results of logistic regression analysis showed that the relative risk of present of unstable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII (OR=1.008, 95 % CI 1.000-1.017, p=0.048).

Conclusion. Our results indicate that elevated blood levels of the Hageman factor may be a new biomarker of probability of unstable atherosclerotic plaques presence in the coronary arteries.
ASSOCIATION OF MOLECULAR GENETIC FACTORS WITH THE SIGNS OF ATEROSCLEROTIC PLAQUES INSTABILITY
Authors: Balatsky A. V. , Samokhodskaya L. M. , Boytsov S. A. , Tkachuk V. A.
Published: September 2018

Aim. Analysis of possible associations of polymorphisms of the urokinase system and matrix metalloproteases genes with criteria of atherosclerotic plaques instability.

Material and methods. Totally, 50 patients were investigated, with carotid atherosclerosis (32 males and 18 females). Inclusion criteria were carotid stenosis ≥70% and carotid endarterectomy. Patients were selected to groups according to macroscopic signs of instability of the lesions and thickness of fibrous cap. The groups were compared by the rates of mononucleotide polymorphisms С(-1306)Т (rs243865) gene MMP2, С(-1562)T (rs3918242) and A855G (Gln279Arg, rs17576) gene MMP9, Pro141Leu (C7240T, rs2227564) and С/T 3′-UTR (rs4065) gene PLAU, Lys220Arg (A659G, rs2302524) and T(-516)C (rs344781) gene PLAUR, (-675)4G/5G (rs1799768)gene SERPINE1.

Results. Monofactorial analysis showed the association of the variants 279Gln/Gln of gene MMP9 and 141Leu/Leu gene PLAU with development of macroscopically stable plaques. By multifactorial analysis, only the carriage of genotype 141Leu/Leugene PLAU was associated with development of stable plaques. For the group of genotype carriers 141Pro/Leu and 141Leu/Leu odds ratio is 0,22 (95% confidence interval 0,05-0,93). With the development of plaques with capsule less than 65 mcm, by monofactorial analysis, the associated variants are 3′-UTR C/T gene PLAU and (-516)T/C gene PLAUR, and normal body mass. Presence of obesity and the carriage of allele (-516) C gene PLAUR are protective against the thin cap plaques development. In patients with absent obesity and genotype (-516)T/T gene PLAUR odds ratio for the thin cap plaque occurrence is 10,16 (95% confidence interval 2,5740,16).

Conclusion. In the work, an association is shown of the polymorphism of urokinase system gene (urokinase plasminogen activator and receptor) with criteria of atherosclerotic lesion instability. Also, an association demonstrated of obesity with more stable plaques.
THE INFLUENCE OF HYPOLIPIDEMIC THERAPY ON THE LEVEL OF MODIFIED LOW DENSITY LIPOPROTEIDES
Authors: Lankin V. Z. , Tikhaze A. K. , Konovalova G. G.
Published: September 2018

Aim. To assess the influence of coronary heart disease patients (CHD) therapy with statins or PCSK9 inhibitors influence on the level of oxidatively modified low density lipoproteides (LDL) and activity of erythrocyte Se-glutathione peroxidase (GSH-Px).

Material and methods. To the study, CHD patients were included (9-10 males per group), who during 6 months were undergoing statin therapy — 40 mg per day of pravastatin (group 1) or 0,4 mg per day of cerivastatin (group 2), as the therapy with PCSK9 inhibitor — 420 mg per month evolocumab (group 3) during 1 year. The level of lipohydroperoxide in LDL (LOOH-LDL) was measured in the groups 1 and 2 with the modified method and usage of Fe-xilenolorange; content of oxidized LDL (oxLDL) in the group 3 — with immune chemistry method (assays Mercodia, Sweden). Activeness of GSH-Px in all groups was assessed with the modified methods bound with glutathione reductase system and tret-buthyl hydroperoxide as a substrate.

Results. Simultaneously with the decrease of LDL cholesterol in the groups 1 and 2 there was significant increase (in the group 2 — 6-7 times in 3-6 months of therapy) of the level of LOOH-LDL. In the group 2 there was marked significant decrease of GSH-Px activity beginning from the month 3. In the group 3, with decreased LDL cholesterol there was significant decline in oxLDL with changed activity of GSH-Px.

Conclusion. Statins, effectively decreasing the level of LDL cholesterol, simultaneously induce the oxidation of LDL and decrease the activity of GSH-Px. Inhibitor PCSK9 not only does effectively decrease the level of LDL cholesterol, but also the content of oxLDL, not leading to decreased GSH-Px activity.
CLINICAL ECONOMY EFFICACY OF TARGETED APPROACH TO ACUTE CORONARY SYNDROME PATIENTS MANAGEMENT WITH PERCUTANEOUS INTERVENTION
Authors: Shukil L. V. , Korennova О. Yu. , Podolnaya S. P. , Prikhodko E. P.
Published: September 2018

Aim. Clinical economical grounding of necessity for continuation of a “State Managed Program of Omsk Region “Development of Healthcare in Omsk Region” (the Program) in allowance granted supply with life saving medications of patients after endovascular treatment of acute coronary syndrome.

Material and methods. To the study, by a continuous sampling method, 255 patients included, after endovascular treatment of coronary arteries in acute coronary syndrome during July 1 to December 31 2015, who monthly attended cardiologists office and received free acetylsalicylic acid, clopidogrel and atorvastatin for 12 months. Method of clinical and economical analysis was applied “Increment efficacy of expenses”, and a threshold for self-payment by patients was evaluated.

Results. One-year mortality of the Program participants was 1,2% versus 3,5% in non-participants. Hospitalization rate for repeated acute coronary syndrome was 3,5% versus 9% in non-participants; serious adverse event hospitalization rate was less than 1%. All economically active patients were discharged “to work”.

Calculated parameter of increment efficacy of expenses with the technology “stenting of coronary arteries and drug supply in 2018 (statin, acetylsalicylic acid, clopidogrel or ticagrelor)” was 215906,93 Rub for every additional survived patient with no hospitalizations for repeated acute coronary syndrome during one year after stenting.

Conclusion. Technology of medication supply with life saving drugs of patients underwent endovascular interventions on coronary arteries for acute coronary syndrome is an advantageous investment of budget funds to life quality of patients. The results of the analysis have grounded the necessity to continue program targeted method in acute coronary syndrome patients management after percutaneous intervention taken current clinical guidelines.
THE INFLUENCE OF ATORVASTATIN AND ROSUVASTATIN IN ATHEROSCLEROSIS ON THE PARAMETERS OF CELLULAR IMMUNITY AND IN VITRO LEUCOCYTE ACTIVATION
Authors: Filatova A. Yu. , Potekhina A. V. , Ruleva N. Yu. , Radyukhina N. V. , Arefieva T. I.
Published: September 2018

Aim. To compare the influence of “lipophilic” atorvastatin and “hydrophilic” rosuvastatin on the parameters of cellular immunity in atherosclerosis patients.

Material and methods. Totally, 35 participants included, mean age 62 [57;68] y.o., 18 males and 17 females, directed for follow-up to Myasnikov Cardiovascular Center with preliminary diagnosis coronary heart disease, atherosclerosis of coronary and carotid arteries, and with indications for intensified statin therapy. In 17 patients the dosage of atorvastatin was increased from 20 to 80 mg, in 18 — dosage of rosuvastatin from 10 to 40 mg. All patients at baseline and in 1 month, by the methods of direct immune fluorescence and cytofluometry underwent the measurement of content of monocytes and lymphocyte populations in peripheral blood, incl. regulatory and effectory subpopulations of the latter. Under the circumstances of cellular culture the influence studied, of atorvastatin and rosuvastatin on CD4+ T-lymphocytes populations, as the lipopolysaccharideinduced synthesis of cytokines by monocytes of donors blood.

Results. At the background of atorvastatin, there was marked increase of relative content of circulating regulatory T-lymphocytes (Treg), increase of the relation of Treg/Thelper 17 (Th17) and changes of cellular immunity parameters. Statins did not influence subpopulations of blood monocytes. There was dose-dependent inhibition by statins of CD4+ T-lymphocytes proliferation: atorvastatin action was noted in 10 nM/L, rosuvastatin — in 10 times higher concentration. Introduction ofstatins, 10-100 nM/L, to the culture of monocytes did not influence neither spontaneous, nor endotoxin induced secretion of cytokines.

Conclusion. In therapeutic dosages atorvastatin shows immune modulating activity presenting with an increase of relative content of regulatory T-lymphocytes subpopulations that might be determined by suppression of effectory cells proliferation.
TYPE 2 DIABETES AND CARDIOVASCULAR COMPLICATIONS: IS IT POSSIBLE TO IMPROVE PROGNOSIS BY GLUCOSE LOWERING THERAPY?
Authors: Kobalava Zh. D. , Kiyakbaev G. К.
Published: September 2018

Regardless the fact that type 2 diabetes (DM2) is related to higher risk of cardiovascular diseases (CVD) development and complications, incl. heart failure (HF), usage of the most of glucose lowering drugs (GLD) does not only improve life prognosis, but might increase the risk of HF. Inhibitors of SGLT2 (gliflozines), a novel group of GLD with a unique non-insulin dependent mechanism of action, in a range of large randomized trials passed not only the obligatory test on cardiovascular safety, but have demonstrated ability to decrease the risk of combination endpoint development (cardiovascular mortality, non-fatal MI and strokes) and possibility for HF hospitalization. The conclusions of randomized trials are confirmed by real clinical practice of DM2 patients management, analyzed in large multicenter trials CVD-REAL, CVD-REAL-2. Inthese trials, first time prescribed SGLT2 inhibitors (in Europe, in most cases dapagliflozin) showed significant benefits for other classes of firstly prescribed GLD in a matter of hospitalization risks for HF or all-cause mortality. However, the total period of the gliflozines usage is not that long, so an answer to the question on stability of their effects in broader perspective is expected by the end of ongoing trials in patients with high cardiovascular risk and in HF patients, including those with no DM2.
Unsaturated shear strength of soil with bimodal soil-water characteristic curve
Authors: Satyanaga Alfrendo , Rahardjo Harianto
Published: September 2018

Many research works have been carried out to develop equations for shear strength of unsaturated soil. However, most of the equations are limited to soils with unimodal soil-water characteristic curves (SWCC). The objective of this study is to propose an equation for estimating the unsaturated shear strength of soils with bimodal SWCCs. Several series of unsaturated consolidated drained triaxial tests were carried out on statically compacted sand–kaolin specimens to evaluate the proposed equation. The experimental results indicated that the ϕb angle of the soil with bimodal SWCC at suctions between the first air-entry value (AEV1) and the second air-entry value (AEV2) was less than the ϕb angle at suctions below AEV1. However, the relationships between shear strength and suction at suctions between AEV1 and AEV2 were still linear. At suctions beyond AEV2, the ϕb angle of the soil with bimodal SWCC started to decrease non-linearly. The evaluation results showed that the estimated bimodal shear strength using the proposed equation in this study had good agreement with the shear strength data from the experimental works.
Assessment of Perfusion and Oxygenation of the Human Renal Cortex and Medulla by Quantitative MRI during Handgrip Exercise
Authors: Haddock Bryan Thomas , Francis Susan T. , Larsson Henrik B.W. , Andersen Ulrik B.
Published: September 2018

Background

Renal flow abnormalities are believed to play a central role in the pathogenesis of nephropathy and in primary and secondary hypertension, but are difficult to measure in humans. Handgrip exercise is known to reduce renal arterial flow (RAF) by means of increased renal sympathetic nerve activity.

Methods

To monitor medullary and cortical oxygenation under handgrip exercise–reduced perfusion, we used contrast- and radiation-free magnetic resonance imaging (MRI) to measure regional changes in renal perfusion and blood oxygenation in ten healthy normotensive individuals during handgrip exercise. We used phase-contrast MRI to measure RAF, arterial spin labeling to measure perfusion, and both changes in transverse relaxation time (T2*) and dynamic blood oxygenation level–dependent imaging to measure blood oxygenation.

Results

Handgrip exercise induced a significant decrease in RAF. In the renal medulla, this was accompanied by an increase of oxygenation (reflected by an increase in T2*) despite a significant drop in medullary perfusion; the renal cortex showed a significant decrease in both perfusion and oxygenation. We also found a significant correlation (R
2=0.8) between resting systolic BP and the decrease in RAF during handgrip exercise.

Conclusions

Renal MRI measurements in response to handgrip exercise were consistent with a sympathetically mediated decrease in RAF. In the renal medulla, oxygenation increased despite a reduction in perfusion, which we interpreted as the result of decreased GFR and a subsequently reduced reabsorptive workload. Our results further indicate that the renal flow response’s sensitivity to sympathetic activation is correlated with resting BP, even within a normotensive range.
O trabalho de mulheres na reciclagem: ambiguidades, fronteiras e representações
Authors: Silva Luciana Codognoto da
Published: September 2018

Esta pesquisa visa destacar algumas das representações presentes no cotidiano de trabalho e vida de mulheres sócias da Associação de Reciclagem de Presidente Epitácio - ARPE, localizada no interior do Estado de São Paulo - SP. Utiliza-se a metodologia em história oral, com o emprego de entrevistas semiestruturadas, em paralelo às contribuições teóricas elencadas pelos estudos históricos, culturais e pós-coloniais. Evidenciou-se que, devido às escassas possibilidades de emprego em outros setores laborais do município, muitas mulheres acabaram sendo dirigidas para o trabalho com os recicláveis como forma de gerir o sustento de si e de suas famílias, demarcando, assim, um local de ambiguidades e de fronteiras entre a atuação e a participação feminina em uma atividade profissional considerada honesta, porém, ainda hoje, marginalizada por muitos na sociedade.
Adolescências e judicialização da conduta juvenil
Authors: Cunha Kelita Rejanne Machado Gonçalves , Lopes de Oliveira Maria Claudia Santos
Published: September 2018

A recente retomada da proposição do rebaixamento da idade penal no parlamento brasileiro, em meio a um cenário de crise política e avanço de ideologias conservadoras, se articula com outros fatores, tais como a realização de megaeventos esportivos no Brasil – Copa do Mundo (2014) e Olimpíadas (2016), de forma a interferir no próprio caráter das leis. A admissibilidade da Proposta de Emenda Constitucional (PEC 171/93), em abril de 2015, aqueceu o debate sobre a imputabilidade penal tanto no meio acadêmico, quanto no âmbito da sociedade. É interesse desse estudo discutir tanto as formulações legais que afirmam ou restringem direitos sociais dos adolescentes na sociedade capitalista contemporânea, quanto das políticas públicas propostas para a sua aplicação, ambas entranhadas por concepções de adolescência construídas historicamente, no sentido de pensar os efeitos judicializantes produzidos com a execução de legislações. Neste percurso, apresenta as áreas em análise neste texto, quais sejam: o contexto histórico e os marcos legais para crianças e adolescentes no Brasil; os significados culturais e os valores sociais relacionados à adolescência em uma perspectiva semiótico-cultural, considerando a interdependência entre os movimentos de reforma dos marcos legais e fatores históricos, culturais e econômicos; e, por fim, analisa-se como a criminalização juvenil e a judicialização das relações humanas na contemporaneidade conferem primazia às ações coercitivas e correcionais, em detrimento das ações educacionais.
Variations in the number of genital setae in Raphignathus hecmatanensis species (Acari: Raphignathidae)
Authors: Akyol Mustafa
Published: September 2018

Aim of study: In this study, in 32 females species of the Raphignathus hecmatanaensis Khanjani and Ueckermann, 2003, were found from the samples collected from different of the same date and localities, variations in genital setae numbers were determined in 10 species.Area of study: This study was conducted at the Zoology Research Laboratory, Department of Biology Faculty of Arts and Sciences, Manisa Celal Bayar University. The soil and litter samples were found from Emirdağları, 1300 m a.s.l., Büyükkarabağ village, Bolvadin district, Afyonkarahisar, Turkey.Material and Methods: Soil samples and litter taken from under Crataegus sp., Astragalus sp., Euphorbia sp., Rosacanina sp. in research area were brought to the laboratory in PVC bags and extracted in Berlese funnels for 7 days. Mites accumulating in collection bottles with 70% alcohol, were selected from the samples under a stereomicroscope, left to clear into lactophenol and then embedded in Hoyer's solution. 32 females species of the R. hecmatanaensis were determined and examined.Main results: In Turkish (Afyonkarahisar) specimens, R. hecmatanaensis in 32 females, while 22 females have 6 genital setae (3 pairs), 9 females have abnormal 7 genital setae and one female have abnormal 5 genital setae.Research highlights: It is very interesting, about one-third of the R. hecmatanaensis species have been found to have an abnormal number of genital setae. In this case, genital setae number used for key to the species of Raphignathus is debate.
The plant species used as edge elements and their usage types: The case of KTU campus
Authors: TARAKÇI EREN Emine , DÜZENLİ Tuğba , ALPAK Elif Merve
Published: September 2018

Aim of study: Planting is a landscape arrangement that best integrates aesthetic, functional, ecological and symbolic influences. There are various organization styles, these styles can be generally classified as formal and naturalistic styles. Plants could be used to create borders, for architectural purposes, to create spaces, to screen bad views, for aesthetic purposes, to create emphasis, to compliment buildings, for erosion control, to direct movements, to screen light, to control noise, to provide shade and for climate control. The present study aims to identify the types of plants used as border elements, the space and purposes of their use.Area of study: This study was conducted at the Karadeniz Technical University, located on the Trabzon city.Material and Methods: The main material of the study is planting border elements and Karadeniz Technical University, Kanuni Campus. In the study, observation, data collection, analysis and evaluation were used. At the stage of observation, KTU Kanuni Campus, which is a study area, visited the situation of planting border elements and photographs were taken of the samples that could best represent themMain results: Accordingly, it was determined that the plant border elements at KTU Kanuni campus were used to separate the buildings with the garden, to create spaces, to screen bad views, for aesthetic purposes, to create emphasis, to complement the buildings, to cover the elevation differences, to direct movement, to form borders, to screen the light, and to control the noise.Research highlights: The aim of the present study was to reveal the functions of plant border elements formed with the abovementioned species. In the present study, the adaptation, aesthetic and functional effects of the observed plant border elements on the landscapes they surround and the environment were also investigated.
In vitro α-amylase and α-glucosidase inhibitory assay v1
Authors: Rubí Segura-Campos Maira
Published: September 2018

Diabetes mellitus is an endocrine disease characterized by hyperglycemia that affects the metabolism of carbohydrates, proteins, and fats. The unique approach to decreasing postprandial hyperglycemia is to reduce or slow down dietary carbohydrate digestion. The inhibition of α-amylase and α-glucosidase enzymes is a strong therapeutic goal of controlling the postprandial glycemic reaction. This protocol describes the anti-hyperglycemic activity of aqueous extracts measuring the in vitro inhibition of these enzymes.
Hasselt University protocol for maternal hemodynamic profiling v1
Authors: Gyselaers Wilfried , Tomsin Kathleen , Anneleen Staelens , Sharona Vonck
Published: September 2018

A maternal cardiovascular profile was assessed in every pregnant woman combining three non-invasive techniques to obtain information about arteries, veins, heart and body fluid content (Table 1). A standardized protocol was used as reported in previous studies, as enlisted below.
untitled protocol v1
Authors: Gyselaers Wilfried , Tomsin Kathleen , Anneleen Staelens , Sharona Vonck
Published: September 2018

Normal reference ranges of maternal impedance cardiography, bioimpedance spectrum analysis and venous combined ECG-Doppler sonography, as applied in the protocol for Maternal Cardiovascular Profiling published as10.17504/protocols.io.tffejjn
4% PFA v1
Authors: Ramlugun Girish
Published: September 2018

This protocol makes 100ml 4% PF
ORTA GELİR TUZAĞI: YAPISAL KIRILMALAR ALTINDA E7 ÜLKELERİ İÇİN AMPİRİK BİR İNCELEME
Authors: TIRAŞOĞLU Muhammed , KARASAÇ Fatih
Published: September 2018

İktisat literatürünün yeni ve ilgi çeken konularından biri orta gelir tuzağıdır. Orta gelir tuzağı, genel olarak orta gelirli ülkelerin yavaş büyüme performansı sergileyerek belirli gelir seviyesinde sıkışması ve yüksek gelir grubuna geçememesi olarak tanımlanabilir. Bu çalışmanın amacı, gelişmekte olan ülkeler arasında önemli yere sahip E7 (Gelişen 7) ülkelerinin orta gelir tuzağında olup olmadığını araştırmaktır. Bu kapsamda Robertson ve Ye (2013) yaklaşımı dikkate alınmıştır. Ampirik analizler tek ve iki yapısal kırılmalı birim kök testleri kullanılarak yapılmıştır. Yapılan analizler sonucunda E7 ülke grubunu oluşturan ülkelerden Endonezya, Meksika ve Rusya’nın orta gelir tuzağında olduğu yönünde kanıtlara ulaşılmıştır. Brezilya, Çin, Hindistan ve Türkiye’nin ise genel olarak orta gelir tuzağında olmadığı bulgularına ulaşılmıştır.
Bir ve Çok Âmirî Felsefesinde Tanrı ve Âlem
Authors: Bayır Taşdemir Sümeyye
Published: September 2018

M. Cüneyt Kaya, Bir ve Çok Âmirî Felsefesinde Tanrı ve Âlem, İstanbul: Klasik Yayınları, 2017, 195 s.
Superior mesenteric artery injury during laparoscopic radical nephrectomy
Authors: Kruglov E. A. , Narkevich A. I. , Babich A. I. , Pobedintseva Y. A. , Kudlachev V. A. , Filimonov E. V. , Goncharov A. N. , Unguryan V. M.
Published: September 2018

The authors present to your a en on a rare clinical case of complete intersec on of the superior mesenteric artery in laparoscopic radical nephrectomy. This complica on emerged in the process of learning the technique of laparoscopic radical nephrectomy, before reaching the “plateau” of the learning curve, in condi ons of poor vision and in the interposi on of tissues due to paratumorous inﬁtiltra on. This type of injury has a high risk of total necrosis of the small intestine. However, due to the concerted ac ons of the surgical service and the readiness of surgeons to complete the vascular suture of the main vessels, a successful reimplanta on of the superior mesenteric artery into the aorta was performed. This is conﬁ rmed by postopera ve observa on and examina on, which included CT angiography. It should be noted that descrip ons of cases of aor c reimplanta on of the superior mesenteric artery are extremely rare in the world and national literature, except for cases of mesenteric ischemia. This case contributes to the description of rare cases of aor c reimplanta on of the superior mesenteric artery and shows the correctness of the selected surgical tactics.
Epidemiological aspects of scrotal and testicle trauma in modern metropolis
Authors: Yarovoy S. K. , Khromov R. A. , Voskanyan Sh. L.
Published: September 2018

The article analyzes the data of 414 patients with scrotal and testicular injuries treated in 2008–2017 by the forces of urgent andrologic service in Moscow.More than 90% of patients who applied for injury to the scrotum and testicle were under the age of 60 years. In peacetime, in the conditions of the metropolis (Moscow) in the vast majority of cases there is a blunt (without breaking the integrity of the skin) injury of the scrotum and testicle (a total of 89.4%). Of these, 77.3% are blunt sports and domestic injury of the testicle of varying severity with a pronounced predominance of relatively light injuries, in particular, the bruise of the testicle. Open injuries are relatively rare-a total of 10.6%. Among open injuries, ruptures of the scrotum without damage to its organs are predominate (63.6% of the total number of patients who applied for open wounds of the scrotum and its organs).The need for emergency surgical interventions in scrotal injury was unexpectedly low-53.1%, which is due to the predominance of mild trauma options – scrotal injury and testicular injury (a total of 61.4% in the frequency of urological care), in certain situations allowing the possibility of conservative treatment or even dynamic observation.
Cough Hypersensitivity Syndrome – A Major Advance in the Understanding of Chronic Cough
Authors: Chung Kian Fan ,   National Heart & Lung Institute, Imperial College London & Royal Brompton & Harefield NHS Trust, London, UK
Published: September 2018

Cough is a common complaint that often necessitates a visit to a primary care provider,1 but tpically resolves spontaneously within a few weeks. Chronic cough, which is a cough that has lasted for more than 8 weeks, is a more difficult condition to manage and satisfactory control is not achieved in a substantial number of patients.2 It has been suggested that many cases of chronic cough may share a common mechanism: that of a hypersensitive cough response.3 This has led to the definition of a new disease entity: cough hypersensitivity syndrome (CHS).4–6 In an expert interview, Professor Kian Fan Chung of the National Heart & Lung Institute, Imperial College and the Royal Brompton & Harefield NHS Trust, London, UK, discusses CHS and the recent advances in our understanding of this condition that is leading to the development of novel treatment approaches.
Comunidades indígenas, tierra y recursos naturales frente a las políticas públicas del Estado Colombiano
Authors: Pavajeau Rico Gina Bibiana
Published: September 2018

El objetivo de este estudio se concentro en identificar porque los gobiernos han ignorado los preceptos constitucionales y las normas supranacionales al expedir políticas de estado para las comunidades indígenas que menoscaban los derechos que ostentan sobre sus tierras y recursos naturales, Para tal efecto, se hizo uso del método analítico crítico descriptivo, arrojando como resultado que en la nación no existen políticas públicas indigenistas en esta materia como tal. Concluyendo que es necesario dar aplicación a la consulta previa, libre e informada estipulada en el Convenio Internacional 169 de la OIT en la implementación de políticas públicas que los involucren.
Enfoque Cluster: Una Herramienta de Emergencia y Vínculo para el Desarrollo
Authors: Blanco Alvarado Paula Jimena
Published: September 2018

El artículo se centra en el impacto de los mecanismos de coordinación de la acción humanitaria, a partir de la Reforma Humanitaria (2005); teniendo como centro de análisis el Enfoque de Clusters, como una herramienta de liderazgo y coordinación. Tiene la finalidad de analizar el estado de la cuestión, estudiar el desajuste entre los mecanismos de coordinación, y elaborar una propuesta de reajuste a través de la conexión entre el Enfoque de Cluster y el Enfoque VARD. Se enmarca bajo la actual Reforma Humanitaria, y tiene como centro de análisis los enfoques mencionados anteriormente y una propuesta basada en la necesidad de alinear el Enfoque VARD con el Enfoque Cluster; con la finalidad de convertir a este último, en una herramienta que facilita la transición de la fase de emergencia a la de desarrollo y mejora de la acción humanitaria en su aportación al desarrollo de la comunidad.
El sindicalismo docente en el contexto socio laboral de Colombia
Authors: Bocanegra Acosta Henry
Published: September 2018

Artículo de investigación en el que se presenta el estado del arte sobre el sindicalismo docente en Colombia. Se hace un inventario de los trabajos que han abordado sistemáticamente el tema, se sintetizan los hallazgos y sus aportes teóricos y empíricos, en la línea de valorar el estado actual de la investigación. Se pretendió darle respuesta a un problema de investigación ¿Cuál es el estado de la investigación sobre el sindicalismo docente en Colombia? Desde el análisis documental y de texto se logró elaborar el trabajo de síntesis que registra este documento.
Dos conceptos de modernidad
Authors: Baquero Sergio Angel
Published: September 2018

Al tomar como referencia el proyecto mundial de liberalización de Enrique Dussel, según el cual se debe dejar a un lado el proyecto de realización habermasiano y se debe emprender el camino hacia la transmodernidad, el presente escrito se propone indagar acerca del concepto de modernidad en orden a reivindicar una mirada desde América Latina sobre el pensamiento político. Por ello, se parte de la premisa de que el mito fundacional de la modernidad no es la ilustración sino el descubrimiento de América, en la medida en que allí aparece la matriz colonial en la que Europa se convierte en el centro del mundo. Bajo este presupuesto, el escrito termina con un análisis propedéutico sobre el pensamiento periodístico de Antonio Nariño desde la perspectiva de la modernidad-alteridad en la que se defiende una lectura no ilustrada del personaje. Metodológicamente se tomarán los principales trabajos de Enrique Dussel en los que se defiende la teoría de los dos conceptos de modernidad, para luego analizar el pensamiento de Antonio Nariño a través de algunos de sus principales textos periodísticos.
Le lien de causalité et la responsabilité des hôpitaux publics à l’époque de la révolution médicale. Une étude de la jurisprudence administrative française à la fin du XXe si&
Authors: Calle Meza Melba Luz
Published: September 2018

Dans cet article le traitement de la causalité est analysé dans la jurisprudence du Conseil d’État et de tribunaux administratifs français sur la responsabilité des hôpitaux publics, au cours de la période dite de la révolution médicale, à la fin du XXe siècle. Ce furent des années de grands changements liés aux progrès de la science médicale, et des services de santé publique. De même, ce furent les années de la réforme du contentieux administratif. Et on a constaté que, en plus des difficultés d’établir le lien de causalité, les dits progrès ont pu intervenir au développement d’outils juridiques innovateurs, tels comme, la présomption de faute et la présomption de causalité, entre autres. Cette inclination du juge administratif peut être considérée justifiée parce que à ces formes juridiques la condition requise de certitude absolue est réduite en matière du lien causal. Cela pourrait découler, de même, de la considération, de la part du juge, de la gravité extrême des dommages d’habitude causés aux victimes par les déficiences dans la prestation du service de santé publique. De la même façon, ladite orientation jurisprudentielle pourrait être interprétée comme une position avancée du juge administratif français de principes des années quatre-vingt-dix sur les méthodes d’évaluation de la causalité. Une ligne peut-être progressiste du juge administratif français qui peut lancer des lumières, depuis une perspective comparée et historique, sur les actuelles études qui dans cette matière sont réalisées dans les pays dont la jurisprudence s’est traditionnellement inspirée du Droit français, comme il est arrivé en Colombie. De même, au XXIe siècle certain degré d’incertitude se reconnaît dans cette question dans laquelle la causalité probabilistique est acceptée. Dans nos jours, la tendance semble être la consolidation d’une distinction nette entre le lien de causalité et l’imputation de la responsabilité administrative.
Neoliberalismo, neoconstitucionalismo y democracia
Authors: Matias Camargo Sergio Roberto
Published: September 2018

El artículo trata sobre el neoliberalismo, el neoconstitucionalismo y su impacto en la democracia, en el contexto nacional e internacional de las últimas cuatro décadas y sus cambios ideológicos, políticos, económicos y sociales. Las inevitables y necesarias reacciones al modelo hegemónico mundial, que enfrentan sus efectos negativos para el desarrollo económico social y para el bienestar de los pueblos. En el territorio nacional, el ascenso intensivo de movimientos sociales opuestos al aperturismo, a los tratados de libre comercio, a las privatizaciones y a la entrega de lo público y del mercado nacional al capital transnacional, por la defensa de la producción agraria e industrial nacional, la soberanía alimentaria, la educación y la salud como derechos fundamentales y por el rechazo masivo a su mercantilización. Se cuestiona la naturaleza del neoliberalismo, del neoconstitucionalismo y su impacto en la democracia. Se aplica un enfoque socio jurídico e interdisciplinario. Se integran los métodos histórico y lógico, el análisis y la síntesis y se utilizan las fuentes primarias y las secundarias.
Constitucionalismo Andino y su desarrollo en las Constituciones de Bolivia, Ecuador, Perú, Colombia y Venezuela
Authors: Fajardo Sánchez Luis Alfonso
Published: September 2018

El Derecho constitucional suramericano ha estado, desde sus inicios, enmarcado por fuentes europeas. Sin embargo, con el surgimiento de los movimientos sociales indígenas, se han iniciado procesos de reflexión sobre las fuentes del derecho propio o derecho ancestral indígena y se cambiado paulatinamente el concepto constitucional de corte occidental introduciendo principios basados en el pluralismo jurídico y la recuperación histórica de las culturas autóctonas. Uno de los pilares del nuevo movimiento constitucionalista, llamado Constitucionalismo Andino, es la inclusión y protección de las culturas jurídicas indígenas, además uno de sus avances ha surgido con la inclusión de principios ancestrales de la cultura incaica como el derecho al “buen vivir” y los orígenes, fundamentos y fuentes de este sistema jurídico. El presente artículo efectúa un estudio comparativo de los países que han desarrollado estos principios mostrando los avances en cada uno de los casos, cambiado la perspectiva del derecho constitucional y la visión de las sociedades.
poder, la guerra y las instituciones:
Authors: Vela Orbegozo Bernardo
Published: September 2018

¿Puede el Estado, cuyo origen está asociado al mantenimiento del status quo, propiciar las reformas necesarias para afrontar los dilemas propios de nuestra sociedad, en los tiempos críticos de la globalización, en aras de posibilitar la reconciliación social en medio de la guerra? En este artículo se estudian algunos de los dilemas propios de la sociedad colombiana que se proponen de manera sistemática desglosando esa cuestión general, así: ¿puede el Estado realizar acuerdos que le permitan imponer el monopolio de la fuerza en todo el territorio y alcanzar con éxito la desmovilización para poner fin a los males de la guerra?, ¿puede el Estado frente a los retos generados por el posconflicto y las demandas del proceso de justicia transicional, garantizar los derechos de las víctimas de la guerra y propiciar el derecho de la sociedad entera a la verdad histórica? Y, considerando que la reconciliación social va mucho más allá del fin del conflicto y la guerra, ¿puede el Estado luchar contra las causas de la violencia y las inercias de la guerra, como los odios y las venganzas que se prolongan en los contextos del posconflicto, haciendo prevalecer los intereses públicos sobre los privados?
An assessment of prescribing skills among dental students in the eastern province, Saudi Arabia, University of Dammam
Authors: Alali Hassan Ayesh , Alali Hassan Abdulmohsen , Alghamdi Abdulrahman Abdullah , Al Ali Abdulaziz Ibrahim , Alkhalaf Ahmed Hassan , Jaffar Balgis
Published: September 2018

Background: The objectives of the study were to assess knowledge and prescription skills of medications among dental student in Dammam University and evaluate the efficiency of an online application in improving their knowledge.Methods: A cross sectional pre-post study was conducted, a total of 96 students from 4th year to interns were enrolled. A formulated questionnaire was distributed to the students. An application that contained the most common drugs used in dentistry was made by the research team with help of the IT department and then launched. The same questionnaire was distributed again after one month from the time they got the application to evaluate its efficiency.Results: Overall knowledge about medications was poor. Fifth year students reported better knowledge than their colleagues. All students have better knowledge about antibiotics compared to other drugs. Overall knowledge about therapeutic agents improved significantly after the web application (p˂0.001).Conclusions: Students have poor knowledge about medications. Using technology is an effective way to improve prescribing skill among dental students.
Clinical profile and risk factors of dermatophytoses: a hospital based study
Authors: Hosthota Abhineetha , Gowda Trupthi , Manikonda Rajini
Published: September 2018

Background: Dermatophytoses are superficial mycoses which represents most common community health problem across the globe. Surveillance studies are required to understand the changing epidemiology and prevalence of causative agents to decide on appropriate therapy. This study aims to evaluate the clinical types, etiological agents and probable risk factors of dermatophytoses.

Methods: It was a cross sectional study of 150 clinically suspected cases of dermatophytoses during six months. Sociodemographic details, clinical history and detailed examination were collected from all the subjects. Skin scrapings were sent to microbiology for direct microscopy and fungal culture.

Results: Among the 150 subjects enrolled, males outnumbered females. Infection was mostly prevalent in the age group of 21-30 years (37.3%). Tinea cruris was the commonest clinical type (50%) followed by Tinea corporis (18.4%) and Tinea unguium (11.9%). Tricophyton rubrum was the aetiological agent isolated in majority (33%), followed by Tricophyton mentagrophytes (20%). The major risk factors of dermatophytoses were poor hygiene (32.1%), topical steroid usage (23.9%) and diabetes mellitus (20.1%).

Conclusions: The present study has provided recent data on etiological agents of dermatophytoses and risk factors in our area. It is essential to develop measures for prevention, control of dermatophyte infections and establishment of therapeutic strategies.
Requerimiento de paquetes eritrocitarios en neonatos: una revisión cualitativa
Authors: Jaramillo Jaramillo Laura Isabel , Villegas Alzate Juan Diego , Ruiz Mejía Camilo , Álvarez Hernández Luis Felipe , Martínez Sánchez Lina María
Published: September 2018

ANTECEDENTES: La trasfusión de hemoderivados, sobre todo de glóbulos rojos, es una de las intervenciones más comunes en la práctica médica diaria. En las unidades de neonatología la población objetivo de esta intervención suelen ser recién nacidos pretérmino, en particular los de alto riesgo con prematurez extrema y con bajo peso al nacer.OBJETIVO: Exponer los aspectos más relevantes de la indicación de hemoderivados a neonatos y la evidencia disponible al respecto: indicaciones, complicaciones, aspectos técnicos y medidas para reducir los riesgos asociados con el procedimiento, como las alícuotas de donante único.DESCRIPCIÓN: Las transfusiones de productos sanguíneos a los neonatos son un procedimiento asociado con múltiples desenlaces desfavorables, como: enterocolitis necrosante, retinopatía del prematuro, hemorragia intraventricular, enfermedad pulmonar crónica, entre otros. La decisión de efectuar este procedimiento debe tomarse con base en las indicaciones establecidas y las posibles complicaciones.CONCLUSIONES: El uso de alícuotas de donante único es uno de los nuevos desarrollos dirigido a disminuir los riesgos asociados y las complicaciones de incompatibilidad.
Serviço Social global em um contexto político: perspectivas radicais
Authors: Uchoa Roberta
Published: September 2018

Trata-se de resenha do livro Global Social Work in a Political Context: Radical perspectives. Além do suporte da economia política, o livro é marcado pelo internacionalismo. Os autores trazem mais de 20 anos de experiências colaborando com práticas do serviço social crítico em países como Grã-Bretanha, Irlanda, Grécia, Canadá, Estados Unidos (particularmente, Boston), Suécia, Hungria, Hong Kong, Espanha, África do Sul, Nova Zelândia e vários países da América Latina, inclusive o Brasil. Aliás, o Brasil aparece em todos os capítulos que estruturam o livro, com destaque à parte que trata do presente e do passado do serviço social no mundo. As contribuições do serviço social brasileiro, em especial no movimento de reconceituação latino americano nas décadas de 1960 e 1970 e na discussão contemporânea sobre a definição da profissão globalmente, evidenciam que os autores mantêm grande interesse no Brasil e estreita colaboração com profissionais e grupos de pesquisas no campo do serviço social crítico brasileiro desde aquele encontro em Estocolmo.
Öz-Yeterlik Algısı ve Örgütsel Sinizm İlişkisi: Algılanan Yönetici Desteğinin Aracılık Rolü
Authors: Ece Süreyya , Kurban Zuhal , Gültekin Selma
Published: September 2018

Bu
çalışmada, çalışanların öz-yeterlik algıları ve örgütsel sinizm arasındaki
ilişki araştırılmıştır. Ayrıca bu ilişki üzerinde algılanan yönetici desteğinin
aracılık etkisi incelenmiştir. Çalışma kapsamında farklı kamu kuruluşlarında
görev yapan 150 kişiyle anket yapılmıştır. Araştırma modelini test etmek için
korelasyon analizi, doğrusal regresyon analizi ve hiyerarşik regresyon analizi
uygulanmıştır. Araştırma sonucunda, öz-yeterlilik algısı ile çalışanların
örgüte karşı sinik tutumları arasında aynı yönde ilişki olduğu ve bu ilişki
üzerinde algılanan yönetici desteğinin tam aracılık etkisine sahip olduğu
bulunmuştur.
Çalışanlarda Erteleme Davranışı (İşyeri Prokrastinasyonu) Gelişiminde Zaman Tuzaklarının Etkisi
Authors: AYDEMİR Sibel
Published: September 2018

Bu
çalışmanın amacı, çalışanlarda erteleme davranışı eğilimi ile zaman tuzaklarını
saptamak, erteleme davranışı ile zaman tuzakları arasında anlamlı bir ilişki
olup olmadığını araştırmak, eğer anlamlı bir ilişki var ise kişi ve iş kaynaklı
zaman tuzaklarının erteleme davranışına etkisini belirlemek ve çalışanların
erteleme davranışının demografik faktörlere göre anlamlı bir farklılık gösterip
göstermediğini incelemektir. Bu amaca bağlı olarak Zonguldak ilinde faaliyet
gösteren özel bir işletmede çalışan 170 kişiden yüz yüze anket yöntemiyle veri
elde edilmiştir. Elde edilen bu veriler SPSS ve AMOS programları ile
değerlendirilmiş, güvenirlik, geçerlilik, frekans, korelasyon, çoklu regresyon,
Mann-Whitney U ve Kruskal Wallis H testleri ile analiz edilmiştir.
Gerçekleştirilen analizler sonucunda; zaman tuzaklarının erteleme davranışına
etki eden önemli bir faktör olduğu, özellikle de kişi kaynaklı zaman
tuzaklarının erteleme davranışı üzerinde baskın bir etkisi olduğu sonucuna
varılmıştır.
Türkiye’de Dijital Vatandaşlıkla İlgili Yapılan Yüksek Lisans ve Doktora Tezlerinin İncelenmesi
Authors: SARİ İsmail , TAŞER Seyit
Published: September 2018

Bu
çalışmanın amacı, Türkiye’de dijital vatandaşlık konusuyla ilgili hazırlanmış
yüksek lisans ve doktora tezlerinin genel eğilimlerini ortaya çıkarmaktır.
Araştırma, tarama modeline dayalı olarak yapılmıştır. Dijital vatandaşlığa
yönelik tezler, Yükseköğretim Kurulu Ulusal Tez Merkezi Veri Tabanından
faydalanılarak elde edilmiştir. Bu doğrultuda, 2004-2017 yılları arasında
hazırlanan 16 adet izinli tez, içerik analizi yöntemine dayalı olarak
incelenmiştir. “Tez Çözümleme Formu” aracılığıyla elde edilen veriler, frekans
ve yüzde hesaplamalarıyla tablolaştırılarak yorumlanmıştır. Araştırma
sonucunda, dijital vatandaşlıkla ilgili tezlerin çoğunluğunun eğitim bilimleri
enstitüsü bünyesinde ve yüksek lisans seviyesinde çalışıldığı saptanmıştır.
Ayrıca tezlerde en çok ilkokul ve ortaokul öğrencilerinin örneklem grubu olarak
tercih edildiği, çalışmaların çoğunlukla karma (nicel + nitel) ve nicel
araştırma yöntemine dayalı olarak yapıldığı ve veri toplama aracı olarak en çok
ölçeklerden faydalanıldığı saptanmıştır.
Machismo and Homosociality in Mamet’s Glengarry Glen Ross
Authors: KALAY Faruk
Published: September 2018

One of
the distinctive persons of American literature and cinema, David Mamet has
written a great number of plays and scripts and many of which are produced or
directed by Mamet himself. Glengarry Glen
Ross consisting of all male characters deals with four real estate salesmen
who do not want to be the bottom name on the board in their office for fear of
dismissal. This fear leads them to manipulation, falsehood and even illegality.
The most conspicuous thing in the play is characters’ relationships to each
other. Characters have a lack of morality and principle. The homosocial office
turns into a macho arena where characters endeavor to survive. Mamet satirizes
a dog-eat-dog society in the play, which has also a reference to American
dream. The characters’ interaction to each other seems primitive and
manipulative despite modern age. In this sense, the play also reveals male’s
inner psychology because human’s instinctual aims such as surviving and potency
are unearthed in the play. In this study David Mamet’s distinctive play Glengarry Glen Ross will be argued with
machismo, homosociality, man’s psychology.