bluuebunny/crossref_metadata_2025 huggingface dataset:
“The Way We Were”
Authors: Zubrzycki GeneviÈve
Published: July 2023

This chapter examines the experience of loss through a study of Rafał Betlejewski's project and his description of it, as well as through an analysis of statements by participants in the “I Miss You, Jew” project. The website provided a venue where Poles could post remembrances of specific Jewish individuals or vanished communities, of places and encounters. The analysis of these testimonies offers a glimpse of how Poles who are invested in the new mnemonic awakening speak of Jews—how they explain Jewish absence from Poland, how they experience that absence, what it means to them, and what that says about them and their vision of Poland. Their discourse shows how the experience of loss may be cast in the genre of nostalgia, even for a time that many of these participants cannot recall because they were not yet born. However romanticized the Jewish past they recall and suffer the “loss” of, these imaginative renderings nevertheless open space for new ways of thinking about history in relation to the Polish future, and they derail the Catholic Right juggernaut, if only for a while and in part. Moreover, some of these discourses engage in genuine historical reckoning with Polish antisemitism.
Reforming Campaigns
Authors: Mares Isabela
Published: July 2023

This chapter examines efforts to adopt electoral reforms that limit the ability of candidates to politicize state resources during campaigns. It considers proposals to adopt such electoral reforms in France and Germany, two countries where this irregularity was pervasive, going back to the authoritarian period. In the initial stages of reforms, legislators affiliated with the governmental majorities opposed these proposals and used their sizable electoral majorities in the parliaments of the period to block the introduction of such reforms. The chapter then looks at the consequences of an elite split in the dominant coalition in both France and Germany for the introduction of these electoral reforms. It documents how considerations about the rising electoral costs of these illicit strategies contributed to a partisan realignment during the period when reforms were considered by parliaments. While Imperial Germany did not adopt new legislation that limited the electoral use of state resources, the chapter highlights important changes in electoral jurisprudence adopted during the decade before World War I that imposed stronger sanctions on this electoral malfeasance.
A case of supernumerary derivative chromosome 22 syndrome in a child
Authors: Olennikova R. V. , Rytenkova O. I. , Volkov A. N.
Published: July 2023

Here we describe a rare case of an abnormal karyotype with a supernumerary derivative chromosome der(22)t(11;22), associated with Emanuel syndrome, in a boy aged 1 year. Familial cytogenetic analysis revealed the maternal origin of the anomaly from reciprocal translocation t(11;22) (q23;q11.2). At the time of the examination, the child had numerous anomalies of development, facial dysmorphia, and a small size of the external genitalia. In addition, there was a pronounced delay in psychomotor development because of the brain damage. We made an attempt to perform a comprehensive analysis of the risks to the patient's health by generalizing the cases of Emanuel syndrome described in the literature.
The effect of fucoxanthin on the development of CCl4-induced liver fibrosis
Authors: Slautin V. N. , Grebnev D. Yu. , Maklakova I. Yu. , Sazonov S. V. , Gavrilov I. V. , Gavrilova E. I.
Published: July 2023

Background. According to current concepts regarding hepatic fibrosis, myofibroblast differentiation from stellate cells, regulated by transforming growth factor-β (TGF-β), is a key step in its pathogenesis. Hence, inhibition of TGF-β-dependent activation of hepatic stellate cells has been suggested as a promising strategy for preventing the disease development.

Aim. To explore whether the administration of fucoxanthin at a dose of 30 mg/kg is efficient in suppressing hepatic fibrosis.

Materials and Methods. The experiments were carried out on 30 outbred ICR/CD1 mice which have been divided into three groups: intact animals, animals with untreated hepatic fibrosis which has been induced by intraperitoneal injections of CCl4 (2 μl/g, 6 weeks, twice per week), and animals which received fucoxanthin per os (30 mg/kg daily for 5 weeks) after inducing hepatic fibrosis as described above. Histological examination was performed by Sirius Red staining using the METAVIR fibrosis and activity score. Immunohistochemical analysis was performed by quantitation of α-SMA-positive myofibroblasts, CD45-positive leukocytes, and TIMP-1-positive regions. Further, we quantified TGF-β in liver homogenate as well as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the serum by means of enzyme-linked immunosorbent assay. An assessment of liver function was conducted by measuring serum alanine aminotransferase, aspartate aminotransferase, and albumin levels.

Results. Fucoxanthin decreased the number of myofibroblasts and leukocytes, the volume of connective tissue and TIMP-1-positive regions, and the level of TGF-β in the liver homogenate, altogether indicative of ameliorated hepatic fibrosis. In accord, treatment with fucoxanthin reduced serum IL-1β, TNF-α, alanine aminotransferase and aspartate aminotransferase, and increased serum albumin.

Conclusion. Treatment with fucoxanthin at a dose of 30 mg/kg has an antifibrotic effect and diminishes liver fibrosis.
Predictors of ischemic and hemorrhagic complications in patients with myocardial infarction at 18-month follow-up: a single-center registry study
Authors: Kashtalap V. V. , Velieva R. M. , Sedykh D. Yu. , Barbarash O. L.
Published: July 2023

Aim. To identify predictors of ischemic and hemorrhagic events in patients with myocardial infarction (MI) after 18 months of follow-up.Material and Methods. The single-center prospective study included 478 patients with MI. The exclusion criteria were as follows: age < 18 years; MI as a complication of myocardial revascularization; atrial fibrillation; intake of anticoagulants after MI. During inpatient treatment, the risk of ischemic and hemorrhagic events was calculated according to the PRECISE-DAPT score, GRACE hospital discharge risk score, CRUSADE bleeding score. After 18 months, we evaluated the rate of ischemic (cardiovascular death, unstable angina, life-threatening arrhythmia, non-fatal MI and stroke, acute decompensated heart failure, elective repeated and/ or emergency revascularization) and haemorrhagic events and the amount of corresponding therapy.Results. At 18 months post-MI, patients were at high risk of developing both ischemic events (cardiovascular death: 32.0%; recurrent MI: 16.3%; repeated myocardial revascularization: 18.5%; unstable angina: 13.8%; stroke: 3.6%) and hemorrhagic events (bleeding rate of 39.7% according to the TIMI score), most of which occurred during the first 12 months post-MI. Double antiplatelet therapy (DAPT) was prescribed to 86.5% patients upon discharge (including a triple antithrombotic therapy in 8.6% patients). Patient adherence to treatment was 66.7% and 60.6% at 6 and 12 months of follow-up, respectively. After 18 months, DAPT was prescribed exclusively to patients suffered from recurrent ischemic events or those who underwent repeated myocardial revascularization (17.4% patients in total). The main reason to cancel DAPT was bleeding, although it was minor in most cases. Predictors of ischemic events (fatal and non-fatal) at 18 months of follow-up were PRECISE- DAPT score (odds ratio (OR) = 1.108, 95% confidence interval (CI) = 1.054-1.164, р < 0.001), GRACE score (OR = 1.032, 95% CI = 1.016-1.048, р < 0.001), left ventricular ejection fraction (LVEF) < 40% (OR = 4.256, 95% CI = 1.510-12.001, р = 0.006). Predictors of hemorrhagic events at 18-month follow-up were PRECISE-DAPT score (OR = 1.025, 95% CI = 1.009-1.041, р = 0.002), peripheral artery disease (PAD) (OR = 2.459, 95% CI = 1.365-4.428, р = 0.003), intake of sulfonylurea for diabetes mellitus (OR = 2.523, 95% CI = 1.266-5.028; р = 0.009), unsuccessful percutaneous coronary intervention (PCI) or conservative treatment of MI (OR = 3.792, 95% CI = 1.799-7.996, р < 0.001).Conclusion. Predictors of ischemic events (fatal and non-fatal) in the long-term period after MI include PRECISE-DAPT and GRACE scores, and LVEF below 40%. Predictors of hemorrhagic events at 18-month follow-up were PRECISE- DAPT scores, PAD, taking sulfonylurea for diabetes mellitus, unsuccessful PCI or conservative treatment of MI.
Pengaruh Perilaku Body Shaming terhadap Tingkat Kepercayaan Diri pada Mahasiswa Psikologi di Universitas
Authors: Nurfitri Aldila Dyas , Putri Anindita Retya , Khikmawati Astriana , Rafli Muhammad Akmal , Fahmy Zulfa
Published: July 2023

Body shaming has emerged as a prevalent phenomenon, particularly among student populations. It involves the act of insulting individuals based on their perceived physical differences. This detrimental behavior significantly impacts one's self-confidence. The present study aims to investigate the influence of body shaming on the self-confidence levels of students at UIN Walisongo Semarang. The research specifically focuses on students enrolled in the psychology study program at UIN Walisongo Semarang. The research methodology employed the scale method and utilized random sampling for data collection. The findings of this study reveal a significant relationship between body-shaming behavior and self-confidence levels among students at UIN Walisongo Semarang. The statistical analysis yielded a significance value of 0.000 < 0.05, indicating that the body shaming variable (X) indeed affects the self-confidence variable (Y).
Inferiority Feeling Serta Aktivitas Fisik Siswa Obesitas dan Implikasi Pelayanan Bimbingan dan Konseling
Authors: Arrahman Iqbal , Firman Firman , Netrawati Netrawati
Published: July 2023

This study aims to find out how to accept Class IX students. The purpose of this study was to increase students' low self-acceptance compared to their classmates. This study used case study methods. which means that the actual conditions that are evident in a situation and the conditions for this study to collect data are by interviewing, In addition, the role of guidance and counseling teachers in handling problems of students with low self-acceptance is to spread AUM (Problem Revealing Tool) to find out the problems that students are experiencing as early as possible. Six of the students who have low self-acceptance have slowly shown the results of their blending in with their friends and starting to participate in activities held both at school and around the residence.
Pengembangan Rencana Pelaksanaan Pembelajaran Tematik Berbasis Strategi Quantum Learning Tipe Tandur Untuk Madrasah Ibtidaiyah
Authors: Afriana Santy , Khoirunisa Khoirunisa , Ajizah Rif’atul , Nugraheni Aninditya Sri Nugraheni
Published: July 2023

This research starts from learning materials that are packaged without using learning strategies. The implementation of the quantum learning strategy is more meaningful because it pays attention to the surrounding environment. This study aims to develop a learning plan that is adapted to the steps of the TANDUR-type quantum learning strategy. The subjects in this study found first grade students at MI Normal Islam Rakha. This study uses research and development (RnD) with a 4D model define, design, develop, dessiminate. Feasibility trials at the development stage were carried out by experts and linguists. The results of research by material experts obtained an average percentage score of 87% with a very decent category. Based on the assessment of linguists obtained an average percentage score of 76.5% with a decent category. This shows that the development of thematic learning plans using the TANDUR type of quantum learning strategy is feasible to be used.
Pendidikan Islam Perspektif Muzayyin Arifin dan Relevansinya Terhadap Pendidikan Islam Kontemporer
Authors: Amini Sofi Alawiyah
Published: July 2023

This research is motivated by Muzayyin Arifin's thoughts about Islamic education. According to Muzayyin Arifin, Islamic education is an educational process that covers all aspects of human life, both worldly and hereafter, guided by Islamic teachings. Seeing today's modernity that is developing rapidly, of course Islamic education plays an important role in becoming a stronghold for society to avoid negative things in the midst of today's modernity. The purpose of this study is to find out Muzayyin Arifin's thoughts about Islamic education and their relevance to contemporary Islamic education. This study used descriptive qualitative research, using library research as a type of research. The results of this study indicate that, Muzayyin Arifin is a rational religious figure in the world of Islamic education who has several works that discuss Islamic education. There are several thoughts of Muzayyin Arifin concerning the nature of Islamic education, the goals of Islamic education, the processes and products of Islamic education, the goals of Islamic education and Islamic education methodology.
Overview Motivasi Belajar Pendidikan Agama Islam: Analisis Menggunakan Bibliometrik
Authors: Nofmiyati Nofmiyati , Miftahuddin Miftahuddin , Darmawati Darmawati
Published: July 2023

Motivation is closely related to the individual's self; positive motivation will give birth to positive things, as well as vice versa. Learning motivation can change one's mindset, success, and interest. Whereas in Islamic religious education, learning motivation is more closely related to religion. The purpose of this study was to look at the motivation for learning Islamic education using bibliometric analysis of years, keywords, and countries. While the method used was searching for data from Scopus with the keywords "motivation to learn" OR "Islamic religious education," it obtained 878 documents after being limited, then entered the Openrefine and Vosviewer stages by storing literature on Mendeley. Research results show that the most documented year is 2022 with 246 documents, while the most commonly used keyword is motivation and the most heavily criticized state has 143 documents.
Differences in Cell Death and BMP-2 Expression in Core Biopsy Specimens of Malignant Bone Tumors Given Hydrogen Peroxide Compared to Liquid Nitrogen
Authors: Kenji Arnaya Agung , Suyasa I Ketut , Wiratnaya I Gede Eka , Sumadi I Wayan Juli
Published: July 2023

Introduction: Malignant bone tumors have a global prevalence of 1% of the overall malignancy case, with a very low 5-year survival rate and high local recurrence. The limb-salvage surgery with bone recycling is widely developed in the management of malignant bone tumors. Hydrogen peroxide and liquid nitrogen are bone recycling mediator agents destroying the malignant tumor cells while preserving healthy bones as much as possible. The purpose of this study was to compare the effectiveness of hydrogen peroxide and liquid nitrogen with the number of tumor cell deaths using the Huvos score and BMP-2 expression in malignant bone tumors.

Materials and Method: In vitro experimental research was performed on 30 core needle biopsy samples of bone malignant tumors divided into 2 groups of hydrogen peroxide and liquid nitrogen. The parameters measured are Huvos score and BMP-2 level.

Results: Based on this study, the characteristics of malignant bone tumors were dominated by primary tumors (83.9%), in female patients (53.3%) with an average age of 30 years. Liquid nitrogen gave better results than hydrogen peroxide, marked by a lower Huvos score (average 12.13 vs. 18.87, p=0.033) and a higher BMP-2 (average 39.53 ± 26.59 vs. 63.87 ± 27.61, p=0.020).

Conclusion: Liquid nitrogen is an effective bone recycling agent for the management of malignant bone tumors.
Comparative Efficacy of Combined Formulation of Andrographis paniculata, Lagerstroemia speciosa and Tribulus terrestris with Glimepiride on Renal and Pancreatic Injury in Alloxan Induced Type-1 Diabetic Mice
Authors: Hazra Popy , Istiak Abu Saleh Md Efad , Koly Kamrun Nahar , Akter Fatema , Ferdous Md. Faisal , Das Shila Rani , Hasan Mohammad Izmal , Haque Azizul , Hayat Sajedul , Sultana Nasrin , Rafiq Kazi
Published: July 2023

Many medicinal plants are becoming increasingly popular for the treatment of various ailments, including diabetes, all around the world. This study was designed to elucidate the comparative efficacy of Tribulus terrestris, Andrographis paniculata, and Lagerstroemia speciosa on glucose intolerance, lipid profile, renal and pancreatic injury in alloxan induced type-1 diabetic mice. In this study, four-week-old male Swiss Albino mice were divided into six groups of five each. To assess toxicity, Group-X was given saline water, while Group-Y was given a combination herbal formulation at a high dose (1 g/kg bwt). No adverse effect of combined formula on body weight and blood glucose was observed in normal healthy mice. The other four groups were labeled as Group-A, healthy normal mice; Group-B, Diabetic mice; Group-C, Diabetic mice treated with Andrographis paniculata, Tribulus terristris @ 200 mg/kg and Lagerstroemia speciosa @ 0.5ml/animal; and Group-D, Diabetic mice treated with Amaryl®@ 800 g/kg bwt. The combined formulation improved body weight loss significantly (P<0.001) compared to diabetic control group after 8 weeks of treatment. Combined formulation and Amaryl® decreased non-significantly total cholesterol, plasma triglyceride and plasma creatinine level compared to diabetic control. However, HDL and LDL levels remained unchanged by the treatment. Consistent with these findings, histopathological evaluation revealed that combined formulation partially improved renal glomerular sclerosis and hypertrophy, tubular damage and pancreatic β-cells damage reflected its renal and pancreatic damage curative property. The obtained results suggest that combined use of Andrographis paniculata, Tribulus terrestris and Lagerstroemia speciosa as antidiabetic herbal formulation, synergizing its therapeutic value in treating hyperglycemia and diabetes related complications mainly renal and pancreatic injury.
Pengaruh Personality Traits dan Literasi Keuangan terhadap Intensi Berwirausaha Mahasiswa
Authors: Hasanah Nesi - , Friyatmi Friyatmi
Published: July 2023

This research aims to analyze the effect of 1) Personality Traits on Financial Literacy of Economic Education Students 2) Personality Traits on Entrepreneurial Intentions of  Economic Education Students 3) Financial Literacy on Entrepreneurial Intentions of Economics Education Students. This is a  quantitative research with a causative approach. The  technique of sampling is proportional random sampling and the number of  sample is  85 students economic education . The data used are secondary and primary data. The data was collected using documentation and questionnaires. It analyzed using path analysis, t test and coefficient of determination with SPSS aplication and alpha 0.05. The results shown that 1) Personality Traits has a impact in  poitive on Financial Literacy but it is insignificant  2) Personality Traits has a positive impact and significant on Entrepreneurial Intentions 3) Financial Literacy has a negative and insignificant on intentions of  entrepreneurial.
Ricuh Skandal Laporan Keuangan : Bagaimana Menilai Kinerja Keuangan PT. Garuda Indonesia,Tbk Menggunanakan Analisis Du Pont?
Authors: Fitriyani Yuniar
Published: July 2023

PT Garuda Indonesia, Tbk is the government's largest airline company, experienced irregularities in its 2018 financial statements which were published stating a profit, while the previous quarter's financial statements reported a loss. This irregularity reaped a polemic which ended with a sanction from the OJK in the form of a fine and the need to restate financial statements. The purpose of this study is to determine the financial performance of PT Garuda Indonesia, Tbk after the restatement using the Du Pont System analysis so that the causes of the ups and downs of the ROE, ROI, NPM and TATO variables as components of the analysis are known, so that the company can prepare the type of strategy taken to avoid severity. The results of the study found that the financial performance of PT Garuda Indonesia Tbk is in an unhealthy condition.
Pengaruh Adversity Quotient dan Personal Attitude Terhadap Minat Berwirausaha Mahasiswa
Authors: Marna Jean Elikal , Putri Dianita Dwi
Published: July 2023

The aims of this research is to investigate the influence of Adversity Quotient and Personal Attitude on Entrepreneurship Interest in Economics Education students. This study's population consisted of 216 students enrolled in Economics Education at Padang State University's Faculty of Economics in 2018, 2019, 2020, and 2021. This study employed Proportionate Stratified Random Sampling as its sampling method. The data used are both primary and secondary. The data gathering tool used is a questionnaire. Descriptive analysis, analysis precondition test, multiple regression, T test, F test, and determinant coefficient were employed in data analysis. The sesult of this research is student's interest in entrepreneurship will be high if student has a positive view of what they are doing, this view will lead someone to be able to maintain or continue his interest in entrepreneurship.
Analisis Confirmatory Faktor Pembentuk Suksesi Family Bisnis UMKM di Kota Payakumbuh
Authors: Kumala Hikmil , Yulhendri Yulhendri
Published: July 2023

The study aims to analyze how the influence of succession on the sustainability of family businesses in Payakumbuh City. This type of research is a quantitative descriptive study that uses primary and secondary data with data sources coming from people who have family businesses in Payakumbuh City. The analytical method used is Confirmatory Factor Analysis (CFA).The results of the analysis show that the social responsibility variable has no significant effect on the sustainability of the family business in Payakumbuh city. The succession variable has no significant effect on the sustainability of the family business in Payakumbuh. This happens because the sample in this study is still a lot of family businesses or new SMEs in Payakumbuh City.
Peningkatan Kemampuan Mengetik Siswa Melalui Penggunaan Aplikasi Typing Master Sebagai Media Pembelajaran
Authors: Marwan Marwan , Wardani Mira Wira
Published: July 2023

This study aims to find out to determine increase students' speed before using the application and after using the Typing Master application in the OTKP major at SMK Nusatama Padang, and improving students' typing accuracy before using the application and after using the Typing Master application in the OTKP major at SMK Nusatama Padang. This type of research is class action research (CAR). The research design used consisted of several cycle stages starting from the Pretest, Cycle I, Cycle II, and Posttest. This research was conducted on 19 students of class X OTKP 2 SMK Nusatama Padang. The instruments used are observation sheets and assessment sheets. Data collection techniques use observation, tests, and documentation. The data analysis technique used is data reduction, data presentation, and drawing conclusions. The criterion for success in this research was the total number of students who passed the specified typing target, namely 70%, or as many as 14 students graduated from a total of 19 students with a speed of 80 cpm and 90% accuracy. Based on the results of each cycle there was an average increase in the number of students who reached the target, namely in Cycle I 73.68%, Cycle II 68.42%, Cycle III 73.68%, and Posttest 78.94%. That way it can be concluded that the use of the Typing Master application to increase the typing speed of class X OTKP 2 students is declared acceptable.
Analisis Keputusan Pedagang Nasi Kuning Dalam Menetapkan Waktu Berdagang Serta Dampaknya Terhadap Pendapatan
Authors: Putra Agung Darmansyah , Rosdiana Rosdiana
Published: July 2023

The objective of the study was to determine the effect of business location, age of workforce and working hours on the trading decisions of Nasi kuning traders wanting to sell in the morning and at night and whether there is a significant difference in income between the two types of Nasi kuning traders. The method used is associative and comparative methods. The collection techniques were observation, interviews and distribution of questionnaires which were distributed to 60 respondents where 30 respondents were selling in the morning and 30 respondents were selling at night. The analytical tools in this study are SEM-PLS and t-test analysis. The results showed that the age of the workforce did not have a significant effect on the trading decisions of Nasi kuning traders, business location and hours of work had a significant effect on the trading decisions of Nasi kuning traders, meanwhile there was a difference in income between Nasi kuning traders who sold in the morning and Nasi kuning traders who sold selling at night, where the net income of Nasi kuning traders who sell in the morning is greater than the Nasi kuning traders who sell at night.
Pengembangan Media Pembelajaran Talking Head Video Beranimasi
Authors: Hidayat M Topit , Syofyan Rita
Published: July 2023

The goal of this research is to create learning media product that are valid and to use. This type of research is known as R&D. Using a 4-D development model with four stages: define, design, develop, and disseminate. The feasibility of expert validators who are knowledgeable in their fields was taken into consideration when testing this research on class XI IPS students at SMAN 3 Pariaman. These are the conclusions reached by the research: First, the material experts' validation scored 93.6% in the very feasible category. In the meantime, the media experts' validation received a score of 97.1%, placing it in the very feasible category. So, in general, based on the assessment of the media and material validators, it can be stated that it is very feasible to be used in learning economics on employment materials. Second, the teacher's assessment received a score of 97.5%, while the student's assessment received a score of 88.5%, placing them both in the very practical category. The study's findings lead us to the conclusion that the animated Talking Head Video as a teaching tool for economics subjects is valid and practical to use.
Pemahaman Keberagaman Peserta Didik Berdasarkan Profil Peserta Didik Sebagai Upaya Pemenuhan Target Kurikulum Merdeka
Authors: Kurniawati Tri , Putri Nadia Ayu Rifani
Published: July 2023

The purpose of this study is to provide an understanding of the diversity of students in terms of learning styles and student profiles to fulfill the targets of the Kurikulum Merdeka. The research method used is descriptive quantitative research with a one-way ANOVA analysis. The object of this research is the X.E.5 students at SMAN 2 Padang. The teacher's understanding of learning styles and student profiles is expected to be able to assist teachers in determining appropriate learning strategies and methods so that Kurikulum Merdeka's targets can be achieved. The results show that: 1) Gender differences do not have a significant effect on student learning outcomes; 2) Differences in the work of parents do not influence student learning outcomes; and 3) Differences in learning styles affect student learning outcomes.
Hubungan Minat Mekanik Otomotif dengan Hasil Belajar Siswa SMK Negeri 1 Lintau Buo
Authors: Ismail Ismail , Maksum Hasan , Nasir M , Wagino Wagino
Published: July 2023

Banyak siswa yang belum mengenali minat yang dimilikinya ditunjukkan dengan minimnya perhatian dan keseriusan siswa dalam melakukan kegiatan praktek dan belajar. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana hubungan antara minat mekanik otomotif terhadap hasil belajar siswa pada mata pelajaran perawatan mesin kendaraan ringan kelas XI Teknik Kendaraan Ringan SMK Negeri 1 Lintau Buo. Penelitian ini menggunakan metode deskriptif jenis korelasional. Diketahui adanya hubungan yang positif antara minat mekanik otomotif dengan hasil belajar siswa, ditunjukkan dengan nilai sig nya 0.424 > 0.05 dengan nilai r tabel berdasarkan pedoman derajat hubungan sebesar 0.113 berada diantara 0.00-0.200 yang artinya sangat kurang. Berdasarkan rumus koefisien determinan didapatkan 12,57% yang artinya besarnya kontribusi minat mekanik otomotif terhadap hasil belajar siswa pada mata diklat pemeliharaan mesin kendaraan ringan adalah sebesar 12,57%. 
Many students who do not recognize their interests are shown by the lack of attention and seriousness of students in carrying out practical and learning activities. The purpose of this study is to find out how the relationship between automotive mechanical interest in student learning outcomes in the subject of light vehicle engine maintenance class XI Light Vehicle Engineering SMK Negeri 1 Lintau Buo. This study used a descriptive method of correlational type. It is known that there is a positive relationship between the interest of automotive mechanics and student learning outcomes, indicated by the sig value of 0.424 > 0.05 with the table r value based on the guidelines of the degree of relationship of 0.113 being between 0.00-0.200 which means it is very lacking. Based on the determinant coefficient formula, 12.57% was obtained, which means that the amount of contribution of automotive mechanical interest to student learning outcomes in the eyes of light vehicle engine maintenance training is 12.57%.
Pengumpul Harta Dalam Surat Al-Humazah (Tinjauan Semiotika Ferdinand De Saussure)
Authors: Hikmah Ismi Wakhidatul , Yusup Maulana , Alif Muhammad Nur
Published: July 2023

AbstractThis paper examines the wealth collector in Surah al-Humazah, where they frequently disregard their obligation to worship God and are continually focused on multiplying their riches until they believe all they acquire could make them eternal. They believe they have abundant wealth, so they easily belittle others. This study employed a literature review method based on Ferdinand de Saussure's semiotic theory approach. The stages of the approach are syntagmatic analysis, paradigmatic analysis, binary opposition, and history confirmation. According to the findings of this study, there is coherence between verses in the Surah al-Humazah when using syntagmatic analysis. Second, wealth collectors are those with immoral tendencies who like to curse and blame. Also, they believe that their fortune would be able to eternalize them, making them hesitant to share. Hence, they threatened with hell huthamah. Furthermore, Surah al-Humazah has a secret message for every Muslim to practice social charity to create harmony among individuals in society.Keywords: al-Humazah; Binary opposition; Paradigmatic; syntagmatic. AbstrakTulisan ini membahas pengumpul harta yang ada dalam surat al-Humazah di mana pengumpul harta sering lalai dengan kewajiban ibadah kepada Tuhan dan selalu terfokus pada cara memperbanyak harta hingga mereka mengira harta yang mereka kumpulkan dapat mengekalkannya, merasa memiliki harta yang banyak sehingga mereka dengan mudahnya merendahkan orang lain. Penelitian ini menggunakan metode studi pustaka dengan pendekatan teori semiotika dari Ferdinand de Saussure dengan langkah yang pertama analisis sintagmatik, kedua analisis paradigmatik, ketiga oposisi biner, keempat mengkonfirmasi sejarah. Hasil dari penelitian ini adalah dengan analisis sintagmatik dalam surat al-Humazah terdapat koherensi antar ayat. Kedua, pengumpul harta ialah mereka yang memiliki sifat amoral yang suka mengumpat dan mencela serta menganggap hartanya dapat mengekalkannya sehingga enggan berinfak akibatnya mereka diancam dengan neraka huthamah. Selain itu surat al-Humazah memiliki pesan tersembunyi, yaitu agar setiap muslim beramal sosial dalam kehidupan bermasyarakat sehingga dalam bermasyarakat terjalin kerukunan antar sesama. Kata Kunci: al-Humazah; Oposisi Biner; Paradigmatik; Sintagmatik.
Analisis Tafsir Maqāṣidī Muḥammad Ṭāḥir bin ‘Āsyūr Pada Ayat Qiṣāṣ
Authors: Rohman Abdul , Zulaiha Eni , Taufiq Wildan
Published: July 2023

AbstractThis paper discusses the concept of maqāṣidī Ibn 'Asyūr's interpretation and its implementation in qiṣāṣ verses. The purpose of this paper is to find out the construction of maqāṣidī Ibn 'Āsyūr's interpretation and the implementation of the interpretation of the qiṣāṣ verses in the Qur'an. The method used is descriptive analysis with literature study. The analytical approach used is the Jasser Audah systems approach. The result obtained is that the maqāṣidī interpretation constructed by Ibn 'Āsyūr is generally oriented towards achieving benefit and rejecting damage. Its achievement is based on the realization of safeguarding the five most basic things, namely protecting religion, soul, lineage, property, and mind; This benefit is realized in three forms of maqāṣid, namely maqāṣid 'ām (general), maqāṣid khāṣṣ (special) and maqāṣid juziyyah (partially); Implementation of the interpretation of the maqāṣidī Ibn 'Āsyūr concept in the verse qiṣāṣ results in an interpretation that qiṣāṣ law has five main objectives (maqāṣid), namely enforcing fair laws, preventive goals, nuanced equality, protecting life and creating stability and security of society.Keywords: Ibn ‘Āsyūr; Interpretation of Maqāṣidī; Qiṣāṣ. AbstrakTulisan ini membahas tentang konsep tafsir maqāṣidī Ibn 'Asyūr dan implementasinya pada ayat-ayat qiṣāṣ. Tujuan dari tulisan ini adalah untuk mengetahui konstruksi tafsir maqāṣidī Ibn 'Āsyūr dan implementasi penafsiran pada ayat-ayat qiṣāṣ dalam Al-Qur’an. Metode yang digunakan adalah deskriptif-analisis dengan studi pustaka. Pendekatan analisis yang digunakan adalah pendekatan sistem Jasser Audah. Hasil yang didapatkan adalah bahwa tafsir maqāṣidī yang dikonstruksikan oleh Ibn 'Āsyūr pada umumnya berorientasi pada pencapaian kemaslahatan dan penolakan pada kerusakan. Pencapaiannya didasarkan pada terjaganya lima hal yang paling mendasar, yaitu menjaga agama, jiwa, keturunan, harta dan akal; kemaslahatan ini diwujudkan dalam tiga bentuk maqāṣid, yaitu maqāṣid 'ām (umum), maqāṣid khāṣṣ (khusus) dan maqāṣid juziyyah (sebagian); Implementasi penafsiran konsep maqāṣidī Ibn 'Āsyūr dalam ayat qiṣāṣ menghasilkan tafsir bahwa hukum qiṣāṣ memiliki lima tujuan utama (maqāṣid), yaitu menegakkan hukum yang berkedilan, tujuan preventif, bernuansa persamaan hukum, melindungi kehidupan serta menciptakan stabilitas dan keamanan masyarakat. Kata Kunci: Ibn ‘Āsyūr; Qiṣāṣ; Tafsir Maqāṣidī.
Aplikasi Semiotika Roland Barthes terhadap Makna Takwa dalam QS. al-Hajj [22]: 37
Authors: Falah Zulfikar , Rohmah Miftahur
Published: July 2023

AbstractThis article examines how Roland Barthes' semiotics can be used to understand the meaning of piety in QS. Al-Hajj: 37. The author's background involves the application of the definition of piety as it pertains to the role of the physical and spiritual as it has existed in humans. This study aims to ascertain the true meaning of the word "piety" as it appears in QS. Al-Hajj: 37 from a semiotic standpoint. The descriptive analysis used in this article's research was discovered through library research. Before helping one comprehend how Roland Barthes' semiotics can be applied to the meaning of piety in QS. Al-Hajj: 37. Following a description of Roland Barthes' semiotic theory, the author then discusses the meaning of "piety" in the Qur'an. When Roland Barthes' semiotics are applied to parse the meaning of piety in QS, it leads to the conclusion that there are two levels of the signification of Al-Hajj: 37. In summary, the relational interpretation between the signifiers lafaz al-taqwa and al-wiqayah has been known to be central to the denotative and connotative meanings of piety.Keywords: QS. al-Hajj: 37; Roland Barthes; Semiotics; The meaning of piety. AbstrakArtikel ini menganalisa tentang aplikasi semiotika Roland Barthes terhadap makna takwa dalam QS. al-H{ajj: 37. Latar belakang yang diambil penulis adalah implementasi makna takwa yang disebutkan telah melibatkan peran jasmani dan rohani sebagaimana telah bersemayam dalam diri manusia. Penelitian ini bertujuan untuk mengetahui makna hakiki terma takwa pada QS. al-H{ajj: 37 perspektif semiotika Roland Barthes. Metode penelitian dalam artikel ini menggunakan deskriptif analisis yang diperoleh melalui library research. Sebelum mengarah kepada pemahaman perihal aplikasinya semiotika Roland Barthes terhadap makna takwa dalam QS. al-H{ajj: 37, penulis memaparkan dahulu terkait teori semiotika Roland Barthes, dilanjutkan pembahasan terma takwa dalam al-Qur’an. Sehingga menghasilkan bahwa terdapat dua tingkatan signifikasi pada pengaplikasian semiotika Roland Barthes dalam mengurai makna takwa dalam QS. al-H{ajj: 37. Singkatnya, makna denotatif dan konotatif makna takwa telah diketahui terfokus pada interpretasi relasional antara lafaz al-taqwa sebagai penanda dan al-wiqayah sebagai petanda. Kata Kunci: Makna takwa; QS. al-H{ajj: 37; Roland Barthes; Semiotika.
Tafsir Kesedihan: Solusi Al-Qur’an Terhadap Problem Al-Huzn dalam Kehidupan
Authors: Zulfikar Eko , Iskandar Iskandar
Published: July 2023

AbstractThis article aims to find out the solutions offered by the Qur’an in overcoming al-H{uzn (sadness) that afflicts human life. But before revealing it, the author explains in advance the factors that led to the emergence of al-H{uzn according to the Qur’an. By using a descriptive analytical thematic method, the author concludes that the meaning of al-H{uzn in the Qur'an is a feeling of sadness experienced by a person that can have a positive or negative effect on his life. The factors that cause the emergence of al-H{uzn according to the Qur’an are feelings of fear, misfortune and poverty. The Qur'an also provides a solution to eliminate the sadness that permeates human life, namely by being patient, establishing prayer, always istiqamah, fearing Allah, dhikr to Him, and multiplying infaq. These five solutions can be used as guidelines as well as normative foundations by Muslims so that in life they avoid sadness and worryKeywords: Al-H{uzn, al-Qur'an, life, solution, interpretation AbstrakArtikel ini bertujuan untuk mengetahui solusi yang ditawarkan al-Qur’an dalam mengatasi al-H{uzn (kesedihan) yang menghinggapi kehidupan manusia. Namun sebelum mengungkapnya, penulis menerangkan terlebih dahulu faktor-faktor yang menyebabkan munculnya al-H{uzn menurut al-Qur’an. Dengan menggunakan metode tematik secara deskriptif analitis, penulis menyimpulkan bahwa makna al-H{uzn dalam al-Qur’an adalah perasaan sedih yang dialami seseorang yang dapat berpengaruh positif maupun negatif dalam kehidupannya. Adapun faktor yang menyebabkan munculnya al-H{uzn menurut al-Qur’an adalah perasaan takut, mendapat musibah dan kemiskinan. Al-Qur’an juga memberikan solusi untuk menghilangkan kesedihan yang menyelami kehidupan manusia, yaitu dengan bersabar, mendirikan shalat, senantiasa istiqamah, bertakwa kepada Allah, berzikir kepada-Nya, dan memperbanyak infak. Lima solusi ini dapat dijadikan pedoman sekaligus landasan normatif oleh umat Islam agar dalam menjalani hidup terhindar dari kesedihan dan kerisauan.Kata Kunci: Al-H{uzn, al-Qur’an, kehidupan, solusi, tafsir
Pulmonary Autograft Dilatation and its Risk Factors After Classical Ross Procedure: a Retrospective Single Center Study
Authors: Chernov I. I. , Enginoev S. T. , Ekimov S. S. , Rashidova T. K. , Abdulmedzhidova U. K. , Guliyev M. A. , Ziankou A. A. , Gamzaev A. B.
Published: July 2023

Introduction. Aortic valve replacement with pulmonary autograft (Ross procedure) demonstrated excellent immediate and long-term results. Dilation of the pulmonary autograft in the long-term period is the main reason for repeated surgery. Aim: to study the prevalence of pulmonary autograft dilatation and its risk factors.

   Materials and methods. From April 2009 to December 2022, 158 patients underwent classical Ross surgery. Inclusion criteria: patients aged 18 and older, patients who underwent classical surgery. Exclusion criteria: patients under 18, modifi ed methods of Ross procedure. Follow-up period: 104 (49–124) months.

   Results and discussion. The median age of patients was 33 (25–43) years. Hospital mortality accounted for 0.6 %. Perioperative myocardial injury was 3.8 %, conduction disorder requiring permanent pacemaker implantation accounted for 1.9 %, the incidence of strokes and acute kidney injury requiring hemodialysis was 0.6 %. Ten-year freedom from autograft reoperation was 88.4. Ten-year freedom from reoperation for aortic aneurysm accounted for 92 %. Predictors of autograft dilatation in the long-term period were: age (OR: 0.942; 95% CI: 0.901–0.984, p = 0.008) and the initial size of sinuses of Valsalva (OR: 1.18; 95% CI: 1.027–1.215, p = 0.01).

   Conclusion. Ten-year freedom from autograft reoperation due to aortic dilatation and freedom from aortic dilatation ≥ 45 mm was 92 % and 37.2 %, respectively. The main predictors of autograft dilatation in the postoperative period are the age and the initial diameter of the sinuses of Valsalva.
Atezolizumab and Bevacizumab in Therapy for Patients with Hepatocellular Carcinoma in Real Clinical Practice
Authors: Serebrennikov G. A. , Menshikov К. V. , Sultanbaev A. V. , Musin Sh. I. , Menshikova I. A. , Sultanbaeva N. I. , Lipatov D. O. , Rezyapova A. Sh.
Published: July 2023

Randomized clinical trials and actual clinical practice differsignificantly. Evidence-based medicine develops new agents referring to, primarily, pharmaceutical findings, preclinical studies and, most importantly, randomized clinical trials. Hepatocellular carcinoma is the most common primary malignancy of the liver, and one of the main causes of fatal outcomes among cancer patients worldwide, including in the Asia-Pacific region, with an estimated 800,000 deaths annually. For more than 10 years, sorafenib, a tyrosine kinase inhibitor, was the only authorized treatment for advanced hepatocellular carcinoma. The next stage in the development of drug therapy for hepatocellular carcinoma involved immune checkpoint inhibitors. The combination of atezolizumab with bevacizumab in the phase III trial (IMbrave150) improved outcomes of advanced hepatocellular carcinoma, such as overall survival and progression-free survival (6.8 versus 4.3). The paper presents the trials of atezolizumab and bevacizumab combination, demonstrates comparable data on the treatment of patients with HCC in real clinical practice and data on the phase III IMbrave150. To further analyze the efficacy of the combination of atezolizumab and bevacizumab, prospective clinical trials should include heterogeneous patient groups.
Review of Small Molecule Anticancer NF-κB Inhibitors
Authors: Kzyrgalin Sh. R. , Yamidanov R. S. , Nazmieva K. A. , Gantsev Sh. Kh.
Published: July 2023

Cancer is one of the most common diseases in the world. Th e transcription factor NF-κB plays a key role in various physiological processes including immune response, cell proliferation, cell apoptosis and inflammation. Due to participation of NF-kappa B signaling pathways in carcinogenesis, angiogenesis, and tumor resistance to chemo- and radiotherapy, the factor is considered to be the ideal target for pharmacological treatment of cancer. Th e paper presents a literature review of the RSCI, PubMed, Scopus, Web of Science, Chemical Abstracts NCCN databases and other open access data. The carcinogenesis inhibitors were selected from all NF-κB inhibitors found. Inhibitors with antitumor activity of analytical interest include Bruton tyrosine kinase (BTK) inhibitors, cellular inhibitors of apoptosis proteins (c-IAP), proteasome inhibitors, and one inhibitor of NF-κB translocation to the nucleus. Th e authors analyzed products of diff erent development stages with recorded antitumor activity to varying degrees. NF-κB inhibitors are promising drug candidates, but since NF-κB is involved in most biological processes and the broad spectrum of action can cause side eff ects, the selective action of these compounds is to be explored.
Immunogenicity of full-length and multi-epitope mRNA vaccines for M. Tuberculosis as demonstrated by the intensity of T-cell response: a comparative study in mice
Authors: Vasileva OO , Tereschenko VP , Krapivin BN , Muslimov AR , Kukushkin IS , Pateev II , Rybtsov SA , Ivanov RA , Reshetnikov VV
Published: July 2023

Development of the new tuberculosis vaccines that would be effective in adults is an urgent task: worldwide, the annual death toll of this disease exceeds 1.5 million. In the recent decades, the matter has been addressed in numerous studies, but none has yielded an effective vaccine so far. There are many factors to resistance against tuberculosis; this study focuses on the T-cell response, a mechanism that enables elimination of intracellular pathogens, such as M. tuberculosis. We aimed to develop an mRNA vaccine capable of triggering a pronounced T-cell response to the M. tuberculosis antigens. The in silico analysis allowed us to select epitopes of the M. tuberculosis secreted protein ESAT6 (Rv3875) and design a multi-epitope mRNA vaccine thereon. We assessed the intensity of T-cell response in mice immunized with mRNA vaccines that encode a full-length or multi-epitope antigen. The results of this study in mice show that immunization with a multi-epitope mRNA vaccine produces twice as many IFNγ-secreting splenocytes in response to specific stimulation than immunization with an mRNA vaccine encoding the full-length protein. Thus, the developed multi-epitope mRNA vaccine can be an effective M. tuberculosis prevention agent the mode of action of which involves formation of a pronounced T-cell response.
Redkij sluchaj sochetaniya trihorinofalangeal'nogo sindroma i sindroma Majera-Rokitanskogo-Kyustera-Hauzera
Authors: Батырова З. К. , Большакова А. С. , Кумыкова З. Х. , Кругляк Д. А. , Уварова Е. В. , Чупрынин В. Д. , Мамедова Ф. Ш. , Саделов И. О. , Трофимов Д. Ю.
Published: July 2023

Vydelyayut dva varianta sindroma Majera–Rokitanskogo–Kyustera–Hauzera (MRKKH): tip I, pri kotorom nablyudaetsya izolirovannaya aplaziya matki i vlagalishcha, i tip II, pri kotorom imeyut mesto soputstvuyushchie ekstragenital'nye poroki razvitiya, v ramkah nekotoryh sindromal'nyh sostoyanij. Sindrom Langera–Gideona ili trihorinofalangeal'nyj sindrom (TRPS) — redkoe autosomno-dominantnoe zabolevanie, harakterizuyushcheesya licevym dicmorfizmom i anomaliyami kozhi, nogtej i volos. Vydelyayut dva tipa trihorinofalangeal'nogo sindroma: TRPSI, obuslovlennyj patogennym variantom gena TRPSI, i TRPSII, obuslovlennyj deleciej s vovlecheniem genov TRPS1, RAD21 i EXT. Kak pravilo, poroki razvitiya polovyh organov vstrechayutsya pri tipe II. Predstavleno klinicheskoe nablyudenie TRPSII v sochetanii s MRKKH. Otsrochennaya diagnostika poroka razvitiya polovyh organov privela k dlitel'nomu bolevomu sindromu u pacientki s krajne otyagoshchennym anamnezom i provedeniyu neodnokratnyh hirurgicheskih vmeshatel'stv. Svoevremennoe obnaruzhenie sochetaniya anomalij polovyh organov u devochek s TRPS pozvolyaet ne tol'ko ustanovit' diagnoz, no i okazat' kvalificirovannuyu pomoshch' s uchastiem ginekologa detej i podrostkov, s cel'yu minimizacii vozmozhnyh oslozhnenij.
Current non–price factors of consumer behavior
Authors: Palchikova U. V. , Sazanova S. L.
Published: July 2023

The economic theory of consumer behavior is one of the key theories of modern economic science in general and microeconomic theory in particular. The theoretical and methodological apparatus for studying consumer behavior has evolved along with the development of economic theory, on the one hand, and with changes in its empirical base, on the other. Consumer behavior at the beginning of the 21st century is characterized by complexity, a combination of rational and irrational motives, social and economic values, various non–price factors that form consumer behavior trends. Of greatest interest to the authors of the article were non–price factors that influenced the behavior of Russian consumers in the last thirty years and have an impact at the present stage. On the basis of empirical research, the authors identified a number of new trends in the behavior of modern consumers, established the relationship between non–price factors of demand, trend, demand and purchase decisions.