bluuebunny/crossref_metadata_2025 huggingface dataset:
Endocrine Toxicity of Cancer Immunotherapy Targeting Immune Checkpoints
Authors: Chang Lee-Shing , Barroso-Sousa Romualdo , Tolaney Sara M , Hodi F Stephen , Kaiser Ursula B , Min Le
Published: September 2018

Immune checkpoints are small molecules expressed by immune cells that play critical roles in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) with inhibitory antibodies has demonstrated effective and durable antitumor activity in subgroups of patients with cancer. The US Food and Drug Administration has approved several immune checkpoint inhibitors (ICPis) for the treatment of a broad spectrum of malignancies. Endocrinopathies have emerged as one of the most common immune-related adverse events (irAEs) of ICPi therapy. Hypophysitis, thyroid dysfunction, insulin-deficient diabetes mellitus, and primary adrenal insufficiency have been reported as irAEs due to ICPi therapy. Hypophysitis is particularly associated with anti-CTLA-4 therapy, whereas thyroid dysfunction is particularly associated with anti-PD-1 therapy. Diabetes mellitus and primary adrenal insufficiency are rare endocrine toxicities associated with ICPi therapy but can be life-threatening if not promptly recognized and treated. Notably, combination anti-CTLA-4 and anti-PD-1 therapy is associated with the highest incidence of ICPi-related endocrinopathies. The precise mechanisms underlying these endocrine irAEs remain to be elucidated. Most ICPi-related endocrinopathies occur within 12 weeks after the initiation of ICPi therapy, but several have been reported to develop several months to years after ICPi initiation. Some ICPi-related endocrinopathies may resolve spontaneously, but others, such as central adrenal insufficiency and primary hypothyroidism, appear to be persistent in most cases. The mainstay of management of ICPi-related endocrinopathies is hormone replacement and symptom control. Further studies are needed to determine (i) whether high-dose corticosteroids in the treatment of ICPi-related endocrinopathies preserves endocrine function (especially in hypophysitis), and (ii) whether the development of ICPi-related endocrinopathies correlates with tumor response to ICPi therapy.
Membrane remodeling in clathrin-mediated endocytosis
Authors: Haucke Volker , Kozlov Michael M.
Published: September 2018

Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition to control processes ranging from cell signaling to adhesion, migration and morphogenesis. The formation of endocytic vesicles and tubules involves extensive protein-mediated remodeling of the plasma membrane that is organized in space and time by protein–protein and protein–phospholipid interactions. Recent studies combining high-resolution imaging with genetic manipulations of the endocytic machinery and with theoretical approaches have led to novel multifaceted phenomenological data of the temporal and spatial organization of the endocytic reaction. This gave rise to various – often conflicting – models as to how endocytic proteins and their association with lipids regulate the endocytic protein choreography to reshape the plasma membrane. In this Review, we discuss these findings in light of the hypothesis that endocytic membrane remodeling may be determined by an interplay between protein–protein interactions, the ability of proteins to generate and sense membrane curvature, and the ability of lipids to stabilize and reinforce the generated membrane shape through adopting their lateral distribution to the local membrane curvature.
Meeting report – Cellular gateways: expanding the role of endocytosis in plant development
Authors: Qi Xingyun , Pleskot Roman , Irani Niloufer G. , Van Damme Daniël
Published: September 2018

The occasion of The Company of Biologists' workshop ‘Cellular gateways: expanding the role of endocytosis in plant development’ on 22–25 April 2018, at Wiston House, an Elizabethan mansion in West Sussex, England, witnessed stimulating and lively discussions on the mechanism and functions of endocytosis in plant cells. The workshop was organized by Jenny Russinova, Daniël Van Damme (both VIB/University of Ghent, Belgium) and Takashi Ueda (National Institute for Basic Biology, Okazaki, Japan), and aimed to bridge the gap in knowledge about the endocytic machinery and its cargos in the plant field.
Reproductive performance of asian catfish ( Hemibagrus wyckii Bleeker, 1858), a candidate species for aquaculture
Authors: Aryani Netti , Suharman Indra , Syandri Hafrijal
Published: September 2018

Background: Hemibagrus wyckii Bagridae is one of the important economic fish species that lives in the rivers and reservoir in Riau Province, Indonesia. The present study aimed to determine the reproductive performance of H.wyckii under culture conditions.

Method s: A total of 10 female and 10 male fish were selected, and weight, length, characteristics of egg and sperm, and hatchery performance were measured. Eggs were fertilized using the dry method. Egg weight and egg diameters were measured for 50 eggs per female. Egg size (50 eggs for each fish) was measured using Labo microscope model  L-711 using software camera 3. Then, saline solution was added over the eggs, followed by the addition of pooled sperm from 10 males.

Results: Average relative fecundity, egg weight and egg diameter were 2060±512 eggs/kg fish, 29.86±1.21 mg and 2.67±0.26 mm, respectively. The fertilization rate and hatching rate were 60.91±4.68% and 42.91±2.92% respectively. Sperm characteristics such as volume per fish (mL), pH, concentration (per mL), motility (%) and duration of motility (second) were 0.82±0.20, 7.15±0.12, 3.68±0.15, 72.77±1.46 and 47.5±4.84, respectively.

Conclusion: The study results and scientific observations regarding reproductive performance suggest that H. wyckii can be considered a new candidate species for aquaculture.
Structural-Functional Approach to Determining the Content of Managerial Competence of the Head of Educational Organization
Authors: Тарасенко В. , Tarasenko V.
Published: September 2018

The article presents the results of a study of the management staff of educational organizations, in which it was revealed a contradiction between the need for the education system in the heads of educational organizations with the current level of managerial competence and the presence of systematic professional difficulties in the activities of these leaders in the implementation of management functions. To resolve the revealed contradiction, the author clarifi es the essence of the concepts of «competence», «management competence of the head of the educational organization». A structural and functional model of the educational organization management system is developed as a basis for determining the content of management functions and competence of the head of the educational organization. Clarifi cation of management functions in the context of the structural and functional model of the management system allowed to determine the content of the managerial competence of the head of the educational organization. In the structural and content relation managerial competence is presented as interpenetration of administrative knowledge, skills, experience of administrative activity, motives, values, professional and personal qualities; respectively, set of cognitive, activity and motivational–personal components.
Avaliando a sustentabilidade alcançada por meio de entregas noturnas: o caso da distribuição de combustíveis na cidade do Rio de Janeiro
Authors: Silva Diego Marques da , Bandeira Renata Albergaria de Mello , Campos Vania Barcelos Gouvêa
Published: September 2018

Este trabalho tem como objetivo analisar o impacto que a implantação de iniciativas para aumentar o desempenho do transporte de carga pode gerar na distribuição de combustíveis em áreas urbanas, em relação à sustentabilidade ambiental e econômica, bem como à eficiência da operação. Desta forma, o artigo propõe uma metodologia a ser ­ das iniciativas com maior potencial, em termos de custo e eficiência, para contribuir para o processo de distribuição de combustíveis em áreas urbanas, bem como para a avaliação do impacto de sua implantação, em termos econômicos e ambientais. O resultado apontou a entrega noturna como a prática com maior potencial de ganhos para o setor, de modo que a metodologia proposta é aplicada para avaliar os resultados de um experimento de entregas noturnas de combustíveis na zona Sul da cidade do Rio de Janeiro, em uma das maiores distribuidoras do Brasil. Os resultados do período de teste de entregas noturnas foram comparados em relação às entregas diurnas, prática padrão da empresa. Foram observados diversos resultados positivos durante o processo de entrega noturna, tais como:, 9% de redução no consumo de combustível; 66% de aumento na velocidade média operacional dos caminhões; redução média de 31% no tempo de viagem, possibilitando o aumento do número de viagens diárias por veículo com a utilização de um mesmo motorista; além da redução média de 13% na emissão de poluentes atmosféricos e gases de efeito estufa no meio ambiente.
Estratégia de utilização da folga de tração de trens para planejamento da distribuição de vagões vazios
Authors: Louzada Patricia Costa , Rosa Rodrigo Alvarenga , Foletto Matheus Batista , Pimenta Lucas De Barros
Published: September 2018

No transporte ferroviário, o planejamento da distribuição de vagões vazios é importante porque a maioria dos vagões nas ferrovias brasileiras retornam vazios do pátio de descarga para o pátio de carregamento não gerando receita para a ferrovia e gerando mais custos com maquinista e combustível. Assim, este artigo propõe um modelo matemático de Programação Inteira que se baseia numa estratégia para distribuição de vagões vazios, onde esses são transportados utilizando a folga na capacidade de tração dos trens que circularão com vagões carregados já programados para atendimento às demandas dos pátios. Para avaliar o modelo proposto, foram criadas instâncias baseadas em dados reais da Ferrovia Centro-Atlântica (FCA) que foram resolvidas de forma ótima utilizando o solver CPLEX 12.6. O modelo matemático utilizando a estratégia proposta apresentou redução na formação de trens exclusivos de vagões vazios quando comparada com o planejamento manual da ferrovia.
A case of combination of two autoimmune diseases: type 1 diabetes mellitus and systemic scleroderma in a 13-year-old girl
Authors: Titovich Elena V. , Andrianova Ekaterina A.
Published: September 2018

Systemic scleroderma is an autoimmune disease of the connective tissue of unknown etiology. It is characterized by skin induration, lesions in the musculoskeletal system and the internal organs, and the Raynaud syndrome. An important component in pathogenesis of systemic scleroderma is disturbance of microcirculation involving endothelial proliferation and destruction, wall thickening and narrowing of the microvessel lumen, vasospasm, hemocyte aggregation, stasis, deformation and reduction of the capillary network (obliterating microangiopathy). Two main forms of the disease are distinguished: the diffuse and localized ones. The systemic nature of the diffuse form of systemic scleroderma is most obvious in the skin, but the digestive tract, respiratory organs, kidneys and the cardiovascular, endocrine, musculoskeletal and genitourinary systems are also affected. The incidence rate of systemic scleroderma is 6.3—12 cases per million population. Single case reports on scleroderma combined with other autoimmune diseases, including type 1 diabetes mellitus, in children and adolescents are available in literature. A rare case of a combination of two autoimmune diseases, type 1 diabetes mellitus and systemic scleroderma, in a 13-year-old girl is reported in this paper.
Health status of children conceived by assisted reproductive technologies: endocrinologist’s position
Authors: Zyuzikova Zinaida S. , Volevodz Natalya N. , Grigoryan Olga R. , Degtyareva Elena I. , Dedov Ivan I.
Published: September 2018

Assisted reproductive technologies (ART) are currently widely used around the world because of the increased prevalence of infertility (presently, about 15% of married couples suffer from infertility), as well as the increased access to treatment and public funding for this method. Hence, the number of children conceived by ART is steadily increasing every year.
This review focuses on the pressing problem of the health status of children conceived by assisted reproductive technologies (ART) by analyzing modern publications on the state of physical, gonadal and psychosomatic development, features of the endocrine system and cardiometabolic diseases, the risk of imprinting changes, congenital malformations and oncological disorders.
The data presented that there is no increased risk of childhood cancer or deterioration in quality of life. However, it is expected that the cardiovascular and metabolic risk factors found in childhood can worsen in later life and may ultimately be responsible for chronic cardiometabolic disease. Furthermore, the issue of fertility, especially in the male population conceived by ART, remains open, thus requiring additional longer-term research.
RELEVANSI ASPEK KEMISKINAN DAN FISIK LINGKUNGAN KUMUH PADA PENENTUAN LOKASI PENERIMA PROGRAM KOTAKU (Studi Kasus Kecamatan Pamekasan Kabupaten Pamekasan)
Authors: Andriana Lia , Manaf Asnawi
Published: September 2018

Kemiskinan menyebabkan seseorang tidak bisa memenuhi kebutuhan dasarnya, serta keterbatasan terhadap akses pendidikan, kesehatan, air bersih, sanitasi yang baik serta perumahan yang layak huni. Hal tersebut yang merupakan penyebab munculnya permukiman kumuh. Kabupaten Pamekasan sebagai salah satu Kabupaten yang mendapatkan program KOTAKU dengan 7 (tujuh) Kelurahan/Desa yang menjadi prioritas penanganan untuk mewujudkan perbaikan kualitas hidup masyarakat miskin melalui penataan permukiman yang baik dan sehat. Tujuan penelitian ini adalah mengkaji apakah ada relevansi antara kemiskinan dan permukiman kumuh pada lokasi penerima program KOTAKU di Kecamatan Pamekasan Kabupaten Pamekasan. Penelitian ini menggunakan metode penelitian kombinasi dimana metode penelitian kualitatif menggunakan deskriptif kualitatif dan metode penelitian kuantitatif menggunakan Sistem Informasi Geografi (SIG) dengan metode overlay. Hasil penelitian diharapkan dapat menggambarkan sebaran kawasan kumuh yang nantinya dapat membantu pemerintah dan stakeholder terkait dalam mengambil keputusan guna merencanakan penataan kawasan perumahan dan permukiman kumuh.
IMPLIKASI PERILAKU PERJALANAN PELAJAR PENGGUNA SEPEDA MOTOR TERHADAP KESELAMATAN BERLALU LINTAS (Studi Kasus: Pelajar Sekolah Menengah Atas di Pusat Kota Semarang)
Authors: Anas Nafisah , Manullang Okto Risdianto
Published: September 2018

Movement in Semarang City has dependence on motorcycle, evidenced by the domination of motorcycle that reach 79%. It causes the highest percentage of accident rates by motorcycle users, reaching 66% of 5,378 incidents and 18.4% of them are high school students. Based on that problem, conducted research that aims to understand travel behavior of high school students motorcycle users in Semarang Central City and understand how dependence on motorcycles and safety riding awareness on the student. This research is use mix approach research to combine quantitative and qualitative method. The method of data analysis used in this study are descriptive statistics, network analysis and phenomenology analysis. The results show that social demographic aspects as measured by student participation in additional activities after school affect the student's travel behavior. Schedule and location of activities after school will form student travel pattern and then shaping the student travel behavior. It causes the motorcycle become the main mode of student travel. Besides travel behaviour, motorcycle dependence is caused by accumulation negligence by various parties. Such negligence is the provision of school parking following the demand growth, lack of integration of public transportation modes, and the permission of students to use motorcycles without driver license. Unfortunately, motorcycle dependence has not been accompanied by safety riding, it is evidenced by the percentage of causes of the highest accidents caused by driver factor, which reached 96%. 98% of students had committed traffic violations and 96% of them were deliberate. This is happened because students feel tired due to increased hours of activity from full day school system and additional activities after school so that students become unaware and not obey. These problems cause both well-informed and uninformed students ignore smart riding method.
Banyumas People’s Characteristics Symbolically Reflected on Calung Banyumasan Performance
Authors: Suharto S.
Published: September 2018

This research aims at examining how Banyumas people’s characteristics are symbolically expressed in Calung Banyumasan performance. This qualitative research employs a hermeneutic approach to examine any symbolic meanings in calung performance. The data are collected by literary study, document study, observation and interview, which are then analyzed using content analysis and interactive analysis of Miles and Huberman. The research results show that some song lyrics identify Banyumas people’s images and characteristics such as equality and honesty (cablaka) just like the ngoko level language they use. The performance consists of opening, Lenggeran, Badhudan, and Baladewan acts in the process of illustrating the character of Banyumas people who love jokes and crowd. Some aspects arising in performance reflect Banyumas people as an egalitarian, straightforward, like-to-gather, and syncretic society.
Kvantinės sąmonės teorija tarptautiniuose santykiuose – tarp iliuzijos ir mokslo
Authors: Skurdauskaitė Ieva
Published: September 2018

[only abstract in English; full article, abstract in Lithuanian]

Since the 19th century, social sciences have been dominated by positivist thinking, which is based on the Newtonian worldview and implies mechanistic, deterministic, materialistic and atomistic methodological tools for conducting researches. However, this Newtonian worldview can not explain the phenomenon of consciousness and thus leaves the scientists with the unresolved body-mind problem. The solution has been recently offered by quantum theory, which challenges the classical thinking by completely changing its ontology, or, to be more precise, which aims at unifying social and physical ontology and laying the ground for the minded matter. In one of the most recent and prominent scholarly books, written by A. Wendt and titled Quantum Mind and Social Science: Unifying Physical and Social Ontology, the author claims that consciousness is a quantum mechanical phenomena and that all of us are in fact a walking wave function. If that is true, then human society must also have quantum qualities. Even though A. Wendt offers a solution to one of the long-lasting questions of social science, he leaves us without any explanations of how the theory might impact the discipline of international relations.Therefore, this paper is focused on 3 questions: 1) How does quantum mind theory challenge positivist thinking in international relations? 2) How does it broaden/narrow our current understanding of international relations – namely, what is the relationship between quantum mind theory and other postpositivism theories? 3) How does quantum mind theory impact international relations? An analysis of the challenges posed to classical thinking and a comparison of the differences and similarities with critical theory, postmodernism and constructivism revealed that quantum mind theory is not yet a new social sciences paradigm or a valid independent theory, but that it could be used as a theoretical tool of postmodernism. The main reasons involve a lack of empirical researches, scholarly supporters and consistent epistemological logic. On the other hand, there are a variety of objects and discussions in international relations that can be analyzed using quantum mind theory: quantum entanglement through language, global society and the collective mind, terrorism and the impact it has on global conflicts and communication, quantum diplomacy and others. The implementation of quantum theory principles – quantum coherence, superposition, quantum entanglement, wave and particle duality and uncertainty – into researches of international relations provides scholars with the perspectives of explaining the changing nature of a global world, new unpredictable threats and global commu­nication.
O PRINCÍPIO DO DESENVOLVIMENTO SUSTENTÁVEL E SUAS IMPLICAÇÕES JURÍDICO-SOCIAIS
Authors: Nunes Anelise Coelho , Schimdt Cíntia
Published: September 2018

Todo princípio, como fonte do Direito, fundamenta o sistemajurídico a fim de mantê-lo como um todo lógico e coeso, organizadoa partir da hierarquia axiológica das fontes. A partir disso, infere-se que o princípio do desenvolvimento sustentável tem apresentação não só como fonte do Direito brasileiro - mais precisamente no Direito ambiental - mas também como norma constitucional, e, assim, embasa tanto o sistemaquanto o ordenamento jurídico, já que encontra-se insculpidona norma do artigo 225 da Lei Maior. Como norma constitucional, detém posição hierarquicamente superior em relação às demais normas do ordenamento jurídico, gozando do status da supremacia das normas constitucionais, pela lição kelseniana.
Optimisasi Perencanaan Produksi Pupuk Menggunakan Firefly Algorithm
Authors: Rahmalia Dinita , Rohmah Awawin Mustana
Published: September 2018

In Indonesia, there are many farmers as a livelihood because of fertile soil for agriculture and the demand for food. Production planning is the important part of managing cost spent by the company. In production planning, there are many constraints which have to be satisfied such as the number of productions, the number of workers, and the number of inventory. In previous research, constrained optimizations have been solved by exact method or heuristic method. In this research, production planning optimization will be solved by Firefly Algorithm (FA). FA works as a behavior of Firefly. One of firefly behavior used is less bright firefly will move toward brighter firefly. The simulation results show that FA method can find an approaching optimal solution of production planning like production cost, worker cost, and inventory holding cost satisfying the constraints of the number of productions, workers, and inventory.
Identifikasi Citra Daging Ayam Berformalin Menggunakan Metode Fitur Tekstur dan K-Nearest Neighbor (K-NN)
Authors: Amin Faris Muslihul
Published: September 2018

The research aimed to create a fresh chicken meat identification system to detect differences between formalin and non-formalin chicken meat based on the image of raw chicken meat. Feature extraction method used is the Feature Texture method which is included in the statistical method where the statistical calculation uses a gray degree distribution (histogram) by measuring the level of contrast, granularity, and roughness of an area from the neighboring relationships between pixels in the image then feature extraction, results feature extraction is then classified by K-NN. With the classification using K-NN results obtained high classification accuracy. The K-NN method is a very good method of dealing with the problem of recognizing complex patterns in the form of data training and processing calibration, based on very fast and high accurate literature methods more than other methods. Observation images will be carried out at various distances between the smartphone camera and chicken meat samples.
Subsurface deformation mechanisms beneath a flexible pavement using image correlation
Authors: Bowman April J. , Haigh Stuart K.
Published: September 2018

Flexible pavement structures are widely used in road construction, especially in circumstances where very high traffic volumes are not expected. These structures comprise multiple layers of granular material, which generally have decreasing strength with depth. Failure of these systems is typically observed as rutting on the ground surface, but the failure instigates at depth. In this research, for the first time, observations can be directly made of the progressive failure of these deeper layers under repeated wheel loading due to the combination of a new test apparatus, the Cambridge accelerated pavement tester (APT) and digital image correlation (DIC) technology. The use of a window allowing observation of soil displacements at depth during repeated wheel loading cycles allows the progressive failure to be observed and the changes in soil displacements and strains with different layer thicknesses to be quantified. It was observed that the critical failure mechanisms for thin and thick surficial layers are different, resulting in changes in the rates of surface rutting. Understanding these deformation mechanisms potentially allows savings to be made in road or airfield construction by using correctly sized structural layers.
Fumigant activity of some plant essential oils and their consustent against to Stegobium paniceum and Lasioderma serricorne (Coleoptera:Anobidae)
Authors: Karakoç Ömer Cem , Alkan Mustafa , Şimşek Şeyda , Gökçe Ayhan , Çam Halit
Published: September 2018

In this study, fumigant activity of essential oils obtained from five plants (Mentha piperita (Lamiaceae), Micromeria fruticosa (Lamiaceae), Anethum graviolens (Apiaceae), Salvia officinalis (Lamiaceae) and Mentha spicata (Lamiaceae)) were tested against Stegobium paniceum  and Lasioderma serricorne (Coleptera: Anobidae) in the laboratory condition. For this purpose, essential oils obtained by using Neo-Clavenger
apparatus were applied at 20% (v/v) concentration, dead and live
individuals were recorded at the end of 24 hours. Also, fumigant
activities of plant essential oils at different temperatures
(10-15-20-25-30°C) was determined.
In addition, fumigant activities of eight essential oil components
(Menton, Eugenol, Carvone, Limonene, Menthol, Diapiol, Methyl-eugenol, Linolol) were tested against S. paniceum. At the end of the study, A. graviolens and M. spicata essential oils showed the highest activity for L. serricorne with 97.63% activity and the highest activity was found in M. spicata essential oil with a mortality rate of 97.76% for S. paniceum. Among the essential oil components, Eugenol has the highest fumigant activity of with 60.79% mortality rate. These results indicate that the M. spicata essential oil and eugenol could have significant potential as fumigant in the control of L. serricorne and S. paniceum.
Apuntes para pensar una ecología política de los territorios fronterizos
Authors: Moncada Paredes Martha
Published: September 2018

Al reconocer el avance de las geografías de la extracción sobre territorios que hasta hace poco eran considerados marginales y subalternizados, como las regiones fronterizas, este artículo discute, desde el prisma de la ecología política, las características que adopta este renovado proceso en las áreas fronterizas en América Latina. La internacionalización de las fronteras, el crecimiento de los niveles de seguridad y el vaciamiento social y cultural de estos espacios serían tres características de este nuevo redescubrimiento de los territorios fronterizos, con implicaciones sobre la soberanía y la continuidad de los pueblos que históricamente han habi-tado en estas áreas.
Salidas del laberinto capitalista. Decrecimiento y postextractivismo de Alberto Acosta y Ulrich Brand
Authors: López Terán Héctor Rubén
Published: September 2018

Reseña de "Salidas del laberinto capitalista. Decrecimiento y postextractivismo"
La planificación estatal en el interjuego entre desarrollo y democracia de Patricio Moncayo
Authors: Ojeda Segovia Lautaro
Published: September 2018

Reseña de "La planificación estatal en el interjuego entre desarrollo y democracia"
¡Costureros carajo! Trayectorias de lucha y autogestión en las economías populares argentinas
Authors: Castronovo Alioscia
Published: September 2018

El propósito de este artículo es aportar a la conceptualización de las economías populares, dialogando con autores y perspectivas críticas en las ciencias sociales a partir de un trabajo de investigación etnográfica en Buenos Aires. Se trata de un recorrido en el tiempo y espacio de las tramas sociales, productivas y políticas de la cooperativa Juana Villca, protagonizado por trabajadores y trabajadoras migrantes de Bolivia, que nos introduce en el heterogéneo entramado de las economías populares. Reconstruyendo una genealogía de los procesos que llevan a la conformación de la cooperativa, se reflexiona en torno a los desafíos, potencialidades y límites de la autogestión como experimentación productiva y articulación de una nueva institucionalidad comunitario-popular.
La humillación como una forma socialmente tolerada del mal moral
Authors: Molina Liliana
Published: September 2018

El mal moral se define como un conjunto de acciones intencionales por medio de las cuales se lesiona la dignidad humana y, por tanto, se explica por la negación de derechos. Sin embargo, el mal moral no consiste solo en una negación de derechos, sino también en una experiencia que involucra, entre sus estrategias, la humillación: ésta puede entenderse como una experiencia compleja que implica también al cuerpo. Este artículo afirma que la humillación, como práctica social, es una forma socialmente tolerada del mal moral que incita a la deshumanización de otras personas, produciendo sufrimiento moral. Además plantea la necesidad de pensar la dignidad desde el cuerpo y considerar el sufrimiento como un criterio indispensable para resistir ante prácticas deshumanizadoras.
La solución de Wittgenstein al problema del "concepto caballo", o de cómo hablar acerca de la estructura del lenguaje según el Tractatus
Authors: Chica Pérez Víctor Hugo
Published: September 2018

El artículo propone interpretar la distinción que ofrece Wittgenstein en el Tractatus entre conceptos ordinarios y conceptos formales como una respuesta a las dificultades que se originan en la distinción fregeana entre concepto y objeto, a las cuales la tradición se ha referido como las dificultades del “concepto caballo”. Se mostrará que las expresiones contradictorias y paradójicas que surgen tanto del ataque a dicha distinción (v. g. “el concepto caballo es un objeto”), como de su defensa (v. g. “el concepto caballo no es un concepto”), tienen su origen en la pretensión ilegítima de describir o caracterizar la estructura lógica de la proposición usando para ello otras proposiciones. La distinción entre conceptos ordinarios y formales permite aclarar, primero, en qué sentido esas expresiones son absurdos; segundo, que la distinción entre concepto y objeto solo puede reconocerse en el simbolismo por las características de los signos, pero no puede constituir objeto de descripción.
Las relaciones entre la filosofía y la teoría literaria
Authors: Garrido Miñambres Germán
Published: September 2018

El artículo aborda el potencial que ofrece la filosofía para la renovación de los presupuestos críticos manejados por la teoría literaria indagando en dos aspectos fundamentales. Por un lado, cuestiona que la identificación de la filosofía con la literatura auspiciada por la deconstrucción excluya otras formas de relación entre sus respectivos ámbitos competenciales. Por el otro, propone una forma de hacer productiva la filosofía para la teoría que pasa no tanto por la ampliación de los referentes textuales ya consagrados por la poética como por la plena exploración de sus contextos originales. En lugar de promover la especulación en torno a nuevas referencias filosóficas, se trata de devolver esas referencias a sus entornos textuales de procedencia para obtener nuevas implicaciones de antiguas formulaciones teóricas.
Preparation of aqueous extracts of plants v1
Authors: Mónica Rodríguez García Cecilia , LPE Peraza Echeverría Leticia
Published: September 2018

Aqueous extracts of plants are a simple, economical and eco-friendly alternative to use as a source of antifungal activity. Here is a protocol for extracting any type of plant material (leaves) with water using a simple blender to grind the dried leaves with water and then a series of centrifuges to eliminate the solid waste, finally a series of filtrations to have an aqueous extract sterile. This aqueous extract can be stored at 4 ° C and depending on the plant the activity can be maintained for a fixed period of time.After this process the aqueous extract is ready to be used in bioassays of antifungal activity.
Compounds derived from flavonoids for photovoltaic applications. Computational chemical investigations
Authors: KACİMİ Rachid , ABRAM Tayeb , BEJJİT Lahcen , BOUACHRINE Mohammed
Published: September 2018

In this paper, we present a quantum chemical analysis of geometries and optoelectronic properties of a series of flavonoids and derivatives with the aim to research new molecules for applications in the fields of chemical physics and materials science. The calculations are based on the functional density theory (DFT) level of the B3LYP with 6-31G (d, p). This method was used to calculate the energy of HOMO and LUMO level, the Egap (gap energy), the Voc open circuit voltage). The DFT (TD-B3LYP /6-31G (d, p)) was used to calculate (λmax maximum of absorption) as well as other quantum parameters. The study of organic solar cells cannot be effective unless accompanied by a thorough understanding electronic distribution on the HOMO and LUMO energy levels of the components, so the researchers calculated and discussed the HOMO, LUMO, energy gap, and Voc of the test compounds. The result shows that these studied molecules are good candidates for application in the fields of optoelectronic devices such as OLED, conducting devices and organic solar cells.
Selfie at a museum: Defining a paradigm for an analysis of taking (self-portrait) photographs at museum exhibitions
Authors: Chlebus-Grudzień Patrycja
Published: September 2018

Due to the development of social media, posting one's photos is becoming increasingly popular; they often take the form of, so called, ‘selfie’. The phenomenon of photographing oneself has also occurred in cultural institutions, including museums. The museums are implementing various strategies of reacting to people taking pictures of themselves with exhibits at the background. The article presents an analysis of these reactions, and, based on that, various ways of defining the functions and role of the contemporary museum. The author also attempts to provide an answer to the following question: is posting photographs by visitors an element of creating their own image (‘the Culture of Narcissism’), or is it rather a form of interaction with heritage, of a dialogue with the presented contents (‘remix culture’)?
LEARNING ACTIVITIES IN HIGHER ORDER THINKING SKILL (HOTS) ORIENTED LEARNING CONTEXT
Authors: Nofrion N , Wijayanto Bayu
Published: September 2018

The development of 21st century life requires the higher-level thinking ability developmental for learners. HOTS learning is characterized by; 1) Analysis, Evaluation and Creating, 2) Logical reasoning, 3) Consideration and critical thinking, 4) Problem Solving and Creative Thinking. One effort that can be done by educators to develop higher-level thinking ability for learners is by facilitating learners to do Advanced Learning Activities (ABL) that include: 1) processing/ analyzing, 2) Communicating/ dialogue, 3) discuss/ collaborate, 4) presents/ constructs. ABL is a continuation of Basic Learning Activities which includes; 1) Observing (combination of seeing and hearing), 2) trying/ questioning, 3) searching/ collecting. Therefore, in learning, educators should be more focused on giving learners space to do ABL while still allowing time for ABD as a warm-up activity or initial activity (Schaffolding). The way that can be done as a trigger of Advanced Learning Activities is to present more questions/ tasks/ problems on high cognitive level that is C4, C5, and C6 in every learning. High-level questions/ tasks/ problems will also encourage learners to dialogue and discuss so that collaboration in learning will be created.

Keywords: Basic Learning Activity/ABD, Advanced Learning Activities/ ABL, HOTS oriented Learning

 

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Mudança de paradigma no planejamento dos recursos hídricos por meio da abordagem MCDA: avaliação da bacia do ribeirão Anhumas, em Campinas [São Paulo], Brasil
Authors: Fantinatti Pedro Augusto Pinheiro , Zuffo Antonio Carlos
Published: September 2018

A água é um elemento essencial para a vida. No entanto, o desenvolvimento industrial e o crescimento urbano têm provocado a concentração da população e, consequentemente, de uma quantidade considerável de lixo, causando a degradação dos rios e suas nascentes. Este processo predatório é ainda mais concentrado na América Latina. Consolidam-se as ocupações ilegais em áreas de proteção ambiental. Ações devem ser tomadas para tornar mais eficientes os programas de uso e ocupação do solo, dentro de padrões reconhecidos de sustentabilidade. Devem ser integrados os processos de planejamento, implantação, ocupação e conservação nos projetos de parcelamento do solo, tendo em conta os conflitos e interesses entre os atores, visando à sustentabilidade das bacias hidrográficas. Este trabalho apresenta os resultados da aplicação da metodologia multicritério de auxílio à decisão na avaliação da situação atual e de cenários futuros da bacia do ribeirão Anhumas, em Campinas, São Paulo. O método proposto levou em consideração a sustentabilidade da bacia não apenas em relação às dimensões econômica e ambiental, mas, também, à dimensão social. Os resultados permitiram medir o grau de sustentabilidade da referida bacia a partir dos valores dos atores. Apresentaram-se indicadores inéditos – de sustentabilidade – no uso e ocupação do solo; e, também inédita, a consideração da indicadores de sustentabilidade social em empreendimentos de engenharia. Os atores participantes do processo corroboraram a abordagem MCDA como robusta e flexível, sugerindo sua aplicação em outras áreas da engenharia ou outros setores da sociedade em busca de soluções mais legítimas e duradouras, de fato, sustentáveis.
Kandungan Peroksida Minyak Goreng Pada Pedagang Gorengan Di Wilayah Kecamatan Tembalang Kota Semarang
Authors: Pangestuti Dina Rahayuning , Rohmawati Siti
Published: September 2018

Background: The repeated use of cooking oil can affect the quality of the oil and the nutrient composition in it. The presence of peroxides can be used as an indicator of oil deterioration. Fritter food is snacks by using flour dough which was prepared by deep fat frying method and sold on the street lot.Purpose: This study aimed to describe and analyze the amount of peroxide value of cooking oil used by fritter traders in Tembalang Sub-district, Semarang City.Methods: This is an observational descriptive research which analyzed 25 samples of used cooking oil of 25 fritter traders. Univariate analysis data was used to describe frequency distribution and mean. Analysis of peroxide value was established according to SNI 3741-2013.Results: Research shows that 28% of traders use branded oil, while the rest use bulk oil. Bulk purchased oil has an average peroxide of 8.77 mEq O2 /kg, while the branded 11.71 mEq O2 /kg.Conclusions: Forty-four percent of cooking oil exceeds the maximum peroxide amount (> 10 mEq O2 /kg, SNI 3741-2013). Bulk oil has a lower average peroxide content than branded oils.ABSTRAKLatar Belakang: Penggunaan minyak goreng secara berulang dapat mempengaruhi kualitas minyak dan komposisi zat gizi di dalamnya. Keberadaan peroksida dapat digunakan sebagai indikator kerusakan minyak. Gorengan merupakan makanan jajanan dengan menggunakan adonan tepung yang digoreng dengan minyak berlebih (deep fat frying) dan dijual di tepi jalan.Tujuan: Penelitian ini bertujuan mendeskripsikan dan menganalisis jumlah nilai peroksida minyak goreng yang digunakan pedagang gorengan di Kecamatan Tembalang, Kota Semarang.Metode: Jenis penelitian ini adalah deskriptif observasional. Sampel dalam penelitian ini sebanyak 25 yang didapatkan dari 25 pedagang gorengan. Data analisis univariat digunakan untuk menggambarkan distribusi frekuensi dan rerata. Analisis bilangan peroksida ditetapkan sesuai SNI 3741-2013.Hasil: Penelitian menunjukkan bahwa 28% pedagang menggunakan minyak bermerek, sisanya berupa minyak curah. Minyak yang dibeli secara curah memiliki rerata peroksida 8,77 mEq O2/kg, sedangkan bermerk 11,71 mEq O2/kg.Kesimpulan: Sebesar 44% minyak goreng melebihi jumlah peroksida maksimum (>10 mEq O2/kg, SNI 3741-2013). Minyak curah mempunyai rerata nilai peroksida lebih rendah dibandingkan minyak bermerek.
DUKUNGAN PEMERINTAH DALAM MENCEGAH PENYALAHGUNAAN NARKOBA DI KOTA SURABAYA
Authors: Pina Nuri , Soedirham Oedojo
Published: September 2018

Drugs are a serious problem that need to be solved together. Based on the data from City Narcotics Agency (BNNK) the number of drug abusers in Surabaya is increased. The city of Surabayahas issued local law (Perwali) Number 65 of 2014 about policies and strategies for the area in the field of prevention, Combating Drug Abuse and Illicit Drugs (P4GN). The regulation has been in accordancewith the healthy public policy. The aim of this study is to determine the government’s support in preventing drug abuse. The special purpose is to determine the achievement of the target, implementationconstraints, prevention, and the responsiveness of the community. The research methods was qualitative approach. Collecting the data through in-depth interviews, documentation, and observation. Informants from SKPD that is related to the prevention of drug abusers, employee from BNN Surabaya, and a third resident of drug abusers in Surabaya had selected by purposive sampling. The results in phase to the target is not in accordance with the Perwali, because it still has obstacles ie outreach to street children, and the commitment in activities. The government’s efforts in implementing prevention programs of drug abusers were in conformity with Perwali, including socialization, curriculum integration on antidrug, TOT, the establishment of peer counselor, and the establishment of the youth anti-drug cadre. Responsiveness of people have started going well. People have the awareness and courage to report drug abuse related to BNN city of Surabaya to be rehabilitated.Keywords: government suport, drug prevention, Surabaya
PERILAKU SEKSUAL BERISIKO PENULARAN HIV PADA TENAGA KERJA BONGKAR MUAT DI PELABUHAN KALIMAS SURABAYA
Authors: Margawati Kurnia , Hargono Arief
Published: September 2018

HIV is a disease attacking immune system with sexual behaviors as one of its transmission media, especially for those categorized as high-risk groups. The result of Integrated Survey on Biological Behaviors (STBP) defines the TKBM (informal dockworkers) as one of these high-risk groups. The aim of this study is to identify the correlations between characteristics, knowledge, and behaviors of the dockworker on the transmission of HIV through risky sexual behaviors at Kalimas Dock, Surabaya. This study was conducted based on Cross sectional design and quantitative approach. Interview on the 52 respondents of this study was carried out by using questionnaire. This research used Simple random sampling method to chose responden on dockworkers at PT “X”, located at Kalimas Dock, Surabaya. The analysis of the research used Chi Square analysis on the collected data with signifi cance value α < 0.05. The findings of this study show dockworkers coming home frequency (p-value = 0.026; PR= 2.13), knowledge (p-value = 0.013; PR = 3.04), and attitude (p-value = 0.05, PR =2.05) correlate with transmission of HIV at Kalimas Dock. Meanwhile, other factors, such as educational background (p-value = 0.162), marital status (p-value = 0.705), and access towards HIV transmission relatedcounseling (p-value = 1) do not correlates. These findings imply several recommended that public health officers conduct counseling on preventing HIV transmission for dockworkers in order to improve theirknowledge and attitude on HIV. PT “X” should implement weekly working shift for the dockworkers so that the dockworkers could spend more time with their family.Keywords: HIV, Sexual Behavior, Dockworkers
Apoptosis index of cerebrum and cerebellum neuronal cells in Rattus norvegicus neonates born from mothers treated with 50% food restriction during gestation
Authors: Hapsari Andita , Joewono Hermanto Tri , Widjiati Widjiati
Published: September 2018

Objective: To analyze the difference of neuronal apoptotic index on Rattus norvegicus offspring in cerebrum and cerebellum between food restriction 50% group and control.Materials and Methods: An analytical experimental study with single blind randomized post test only control group using animals subjects Rattus norvegicus. This study was conducted at animal laboratory, Veterinary Faculty, Universitas Airlangga. Animal subjects were divided into food restriction 50% group and control. The apoptotic index was analyzed using comparison test, with significancy p<0.05.Results: There was significant difference of neuronal apoptotic index on Rattus norvegicus offspring between FR 50% group and control in cerebrum with p= 0.002 (mean 6,12±3,51 in FR 50% group, 2,81±2,16 in control group), and cerebellum with p= 0.026 (mean 5,56±3,03 in FR group, 3,43±2,58 in control group).Conclusions: Food restriction 50% during gestation has signifi-cant influence on neuronal apoptotic index in cerebrum and cerebellum of Rattus norvegicus offspring.