bluuebunny/crossref_metadata_2025 huggingface dataset:
Distance Learning Model Innovation for Early Childhood during COVID-19 Pandemic
Authors: Musyafa Ali  , Samiaji Mukhamad Hamid , Cesilia Prawening
Published: September 2021

Purpose – The COVID-19 pandemic has changed many lives, especially in the field of education. These changes start from the level of early childhood education, elementary education, to higher education. The learning process initially done conventionally in early childhood education has now been transformed into distance-learning or online. This sudden transformation of learning is essential to present an innovative distance learning model in the early childhood education environment. This study describes the distance learning model innovation for early childhood, implemented by PAUD Wadas Kelir, South Purwokerto, during the COVID-19 pandemic. Teachers designed this learning model at PAUD Wadas Kelir by combining fun and unique online and offline learning.

Design/methods/approach – This type of research is field research with a descriptive qualitative method. In collecting data, researchers used three methods, i.e., observation, interviews, and documentation. The data analysis technique used, i.e., reducing data, presenting data, and drawing conclusions. Moreover, the validity of the data is tested using triangulation techniques.

Findings – The results of this study show that there are ten learning model innovations implemented by ECE Wadas Kelir, i.e., learning with parental involvement, work projects, study visits, quizzes, online learning, creativity competitions, films and videos, creative and interactive stories, recording materials, and learning appreciation.

Research implications/limitations – This case study focuses on Early Childhood Education (ECE) learning models applied to early childhood education institutions during the pandemic in PAUD Wadas Kelir, South Purwokerto, but it is unlikely that the situation is different elsewhere because the pandemic is Indonesia and global.

Practical implications – This case study demonstrated how the application learning models of ECE during the pandemic are effective for children's growth and development.

Originality/value – This paper contributes to knowledge and understanding of applying several learning models for ECE during the pandemic as reference material in implementing the learning process for early childhood.

Paper type Case study
Science-Learning Strengthening Model in Islamic Educational Institution: Case Study at MAN 1 Yogyakarta
Authors: Taufik Opik Abdurrahman , Sumarni Sumarni , Suprapto Suprapto
Published: September 2021

Advances in science and technology continue to develop and have a broad impact on various aspects of human life, including in the world of education. In order for students to be able to compete in the global world, educational institutions need to strengthen science learning to students. This study aims to explore the advantages of the science-learning strengthening model in Madrasa Aliyah in terms of context, input, process, and output aspects. This study uses a qualitative approach with a qualitative descriptive method. The results of this study indicate that in terms of context, the program for strengthening science learning already exists in the vision and mission of the madrasa, which is to have the advantage of science and technology, which is followed up by madrasa policy to develop KTSP Research and science for local contents and extracurricular activities. From the input side, all were fulfilled except for the laboratory staff who were temporarily carried out by the KIR Trustees. From the process side, science learning strengthening has been carried out well and the output is also quite satisfiying. This can be seen from the score of the National Examination and the number of student achievements, especially in the fields of science and research both in the national and international levels.
Learning the Yellow Book in Al-Fitroh Jejeran Boarding School, Wonokromo Pleret Bantul: Study of Learning Materials in Philosophical Perspective
Authors: Mujahid Mujahid
Published: September 2021

Many studies on boarding school have been carried out before by researchers. But most of these studies are more descriptive by describing what happened in the boarding. While studies about boarding school analyzed with philosophical theory are still rarely conducted. The subjects of this study were caregivers and some students who were selected purposively. The data collection uses observation, interview and documentation. This paper aims to reveal the philosophical perspective of the learning materials of the Yellow Book in al-Fitroh Jejeran Boarding school, Wonokromo  Pleret  Bantul. The philosophical framework used as a reference for the analysis of this study is the Religious-Conservative tradition (al-Diniy al-muhafidz). Religious -Rational (al-Dini al-' Aqliy) and Pragmatic-Instrumental (al-Darai'i) traditions. The results showed that philosophically learning the Yellow Book in that boarding school uses religious-conservative tradition (al-Diniy al-muhafidz). The source of the material taught refers to the yellow books produced by scholars in the Middle Ages. The reason Kyai refers in the classical books because the books were written by salafiyyin scholars closer to its existence with the Prophet, to allow the truth is more assured. According to his beliefs getting closer to the existence of the prophet, the value of truth is more authentic. While the Religious-Rational School (al-Dini al-'Aqliy) has not got an adequate place in the Boarding School.  The existence of general science is not given to students so that the students are not affected by outside influences that will slowly erode and keep students away from religious sciences. While the instrumental pragmatic tradition (al-Darai'i) which is characterized by accommodating a variety of tangible sciences related to the direct needs of humans, both spiritual needs and material needs, must be recognized not all can be organized by the boarding school completely.
Automation of the mechanical tensile and three-point flexural test
Authors: Hernández-Gómez Zaida Margelly , Castillo-Robles Edgar Mauricio , Campo-Ceballos Diego Andrés
Published: September 2021

This paper presents the design and implementation of Mechanical system testing for tensile and three-point flexural test for both metallic and polymeric materials. A control and monitoring system was adapted to the data, using specialized equipment for industrial automation, i.e. PLC system. Main Parameters to perform the tensile and three point flexural tests, and the functional and technical specifications according to the ASTM (American Society of Testing Materials) standards were defined. Conceptual design, mathematical calculations and CAD designs were developed using Solidworks. Graphical user interfaces (GUI) were designed to interact with the user. Human machine interface (HMI) was implemented in proprietary software and includes rules for the supervision and manipulation of core variables for the user according to the ASTM standard. The HMI was interconnected with a programmable logic controller (PLC) where the process selection rules was implemented in GRAFCET diagram, following the ASTM protocols. The system has a test capacity of 500 Kgf both for the tensile test and for the three-point flexural test, with an accuracy of ± 2%, under the ASTM E177 standard, and the HMI interface as an innovative monitoring and control system.
La comunicación y el aprendizaje universitario: la necesidad del cambio institucional
Authors: Santana  Borrego Osvaldo Pedro
Published: September 2021

La calidad de los programas de estudios que se imparten en la enseñanza superior es uno de los temas que se debate por diferentes disciplinas, investigadores y profesionales de la ciencia de la educación. Su impronta en la dirección de la actividad del aprendizaje en los estudiantes, meritan su atención para las políticas de desarrollo a partir de modelos educacionales con una comunicación vertical, asimétrica y autoritaria que para nada se corresponden con la misión de la institución social en el siglo XXI. A partir de esta problemática social, el presente trabajo persigue como objetivo general, analizar los factores que inciden en la comunicación y el aprendizaje universitario como necesidad para el cambio institucional. Transformación que se genera por los pedagogos y educandos en la institución docente como responsabilidad y compromiso con su tiempo. En este sentido, el estudio coloca la mirada a las múltiples estrategias que pueden como beneficio social, asumir la nueva universidad dentro del perfeccionamiento educacional que se desarrolla en la sociedad en este contexto. Asimismo, se exponen un conjunto de dinámicas sobre estas categorías centradas en iniciativas y creatividad, las cuales pueden constituir un punto de reflexión para compartir y enriquecer otras concepciones teóricas metodológicas, que contribuyan a la formación de un pensamiento crítico para la transformación de la realidad. Del mismo modo, se suscita tener en cuenta algunos matices a adjudicarse por la comunicación cada vez más significativa, y lograr el aprendizaje auténtico que permita construir espacios de intercambio de saberes en la actualidad.
Effect of P ect of Passive Tobacco Smoking Exposur obacco Smoking Exposure on the P e on the Periodontal eriodontal Status of Turkish Children
Authors:   Department of Periodontology, Faculty of Dentistry, Canakkale Onsekiz Mart University, 17100, Canakkale, Turkey, ALAN Raif , GEZGİN Onur ,   Department of Pediatric Dentistry, Faculty of Dentistry, Baskent University, Konya, Turkey, KORKUT Emre ,   Department of Pediatric Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey, TÜRKOĞLU Şükriye ,   Department of Pediatric Dentistry, Faculty of Dentistry, Sağlık Bilimleri University, İstanbul, Turkey, ÇELİK Esra ,   Department of History of Veterinary Medicine and Deontology, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey
Published: September 2021

Objective: This study aimed to assess the effect of passive tobacco smoking (PTS) through the comparison of the periodontal status and the C-reactive protein (CRP) and cotinine levels in the biologic fluids in children who are exposed and unexposed to PTS. Methods: A total of 148 participants, whom had smokers (PTS-exposed, n=82) and non-smokers (PTS-unexposed, n=66) in their families, respectively, were included in the study. Gingival index, plaque index, probing depth, and bleeding on probing were recorded. Moreover, saliva, urine, and gingival crevicular fluid samples were collected. CRP and cotinine levels in the biological fluids were determined by the enzyme-linked immunosorbent assay method. Results: Both groups exhibited similar values for periodontal parameters and salivary CRP levels were higher in PTS-exposed group but not significant. The mean urinary cotinine level was significantly higher in children exposed to PTS than in unexposed children. Conclusions: There was no evidence for causative role of PTS in periodontal disease in this study. Longitudinal studies including large populations should be conducted to provide stronger evidence for the causative role of PTS in periodontal disease. Also, further epidemiological studies on the social context of smoking should be performed to improve the quality of life and lifespan of the society
Approaches of General and Specialist Dentists to Deep Caries Management: A Cr Management: A Cross-Sectional Study fr oss-Sectional Study from Turkey
Authors:   Department of Pediatric Dentistry, Faculty of Dentistry, Nuh Naci Yazgan University, Kayseri, Turke, Delikan Ebru , Tuğba Ertürk-Avunduk Ayşe ,   Department of Restorative Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey, Aksu Seçkin ,   Department of Pediatric Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey
Published: September 2021

Objective: To determine the differences in treatment strategies and material preferences for deep dentine carious lesions (DDCLs) management among general and specialist dentists. Methods: Dentists working in universities, oral and dental health centers, or private practice were administered a 14-item web-based questionnaire regarding demographic and occupational characteristics, approaches to DDLCs, pulp capping methods, and preferences for restorative materials. The data were examined using descriptive statistical analysis and Pearson’s chi-square tests. Results: The study enrolled 298 general and 265 specialist dentists among whom 67.1% were female and 73.3% were aged 25 to 35 years. Total excavation and permanent restoration of DDCLs were the commonly preferred treatments (67.0%), although the pediatric dentists tended toward selective caries removal in these lesions. Mineral trioxide aggregate was used more regularly by the pediatric dentists and endodontists. The pediatric dentists exhibited statistically significantly lower preference for canal treatment than general dentists and endodontists as treatment option for mature teeth with DDCLs (p<0.05). Conclusion: Conservative treatment approaches and material preferences of specialists and general dentists in DDCLs are generally different. The age of dentists, the time since their graduation, place of work and the number of patients they have seen daily may affect the approaches and preferences.
The Relationship between Leadership Factors and Successful Technopreneur through the Mediator Role of Digital Enabler
Authors: Alkhoori Ahmed Abdulqader , AL-shami Samer Ali , Sedik Safiah
Published: September 2021

The business digitalization wave has changed the entrepreneurship landscape globally. The existing digital enabler practices and thinks differently through making an item or arrangement that utilizes the ability of innovation to change the way was customarily done, especially in UAE. The power of technology completely changed the economics of an industry, where entrepreneurial venture aims to meet a marketplace or a platform that require them to transform into digital enablers as a successful technopreneur. This research aims to develop a new leadership model for successful technopreneur in the UAE. Adapting the theory of planned behaviors to predict a person's goal to participate in technology behavior and the transformational leadership theory that focuses on a leader towards identifying technology needs for better performance. A survey approach as a primary data collection was applied to test concepts and reflect the attitude of 323 respondents among technopreneur from the Innovation and Entrepreneur Centre located in Abu Dhabi. The data were analyzed through SmartPLS software for Structural Equation Modelling (SEM) using the Partial Least Squares (PLS) path modeling method that indicates that leadership factors of authenticity, devolved decision making, agility, collaborative achievement, and purpose and direction have a positive relationship towards successful technopreneur in UAE. The mediation outcomes of digital enablers indicate a positive relationship between leadership factors and successful technopreneur in UAE.
Comparison of Antibacterial Activity of Sambiloto (Andrographis paniculata) Ethanol and Water Stem Extract Against Methicillin-Resistant Staphylococcus aureus (MRSA) ATCC 3351 In Vitro
Authors: Arini Ni Wayan Sinta Devi , Satriyasa Bagus Komang , Jawi I Made , Indrayani Agung Wiwiek
Published: September 2021

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is penicillin and cephalosporine resistant Staphylococcus aureus which is a major cause of nosocomial infection. Various studies have been conducted for resistant cases, especially herbs which have antibacterial activity. Sambiloto (Andrographis paniculata) is an example of herb which has antibacterial activity due to the presence of andrographolide. Andrographolide soluble in ethanol and poorly in water, while extraction with alcohol causes andrographolide’s degradation. This study aimed to investigate the antimicrobial activity of ethanol and water stem extract and compare them against MRSA ATCC 3351 in vitro.Methods: This is an experimental study with a post-test only control group design and conducted by disc diffusion technique to obtain an inhibition zone against MRSA.Result: The result of this study showed the mean inhibitory zone of ethanol stem extract was 5,87mm, 6,77mm, 7,87mm respectively for 25%, 50%, and 100% concentrations, while 1% concentration did not show antibacterial activity. Water stem extract at 1%, 25%, 50%, and 100% concentrations showed mean inhibitory zone was at 4,57mm, 7,17mm, 8,67mm, and 9,67mm respectively.Conclusion: Ethanol and water stem extract showed antibacterial activity against MRSA. The independent sample t-test didn’t show a difference between ethanol and water stem extract of Andrographis paniculata toward MRSA (p>0,05).
Toxoplasmosis and Cerebral Toxoplasmosis in HIV/AIDS Patients in Kariadi Hospital, Semarang
Authors: Sanni Hassana Dauda , Hadisaputro Suharyo , Sofro Muchlis Achsan Udji
Published: September 2021

Background: Toxoplasmosis is an infection caused by Toxoplasma gondii which affects the central nervous system resulting to a fatal situation in HIV patients especially at the advanced stage. Cerebral toxoplasmosis (CT) is the clinical presentation of toxoplasmosis in individuals with HIV/AIDS. The study was carried to describe the prevalence of toxoplasmosis and cerebral toxoplasmosis in HIV/AIDS patients attending the hospital setting used in the study.Methods: Patients medical records were checked and analyzed for demographic characteristics as well as to determine the results of toxoplasma IgG tests for HIV/AIDS patients as well as those who had cerebral toxoplasmosis. The study was a descriptive study.Results: Out of the 158 HIV/AIDS patients tested, 129 (81.6%) were positive for T. gondii. A 62.0% prevalence rate was recorded for the male subjects while 19.6% prevalence rate was recorded for the female subjects although there was no significant difference (X2=0.58, P > 0.05). 69.3% of the total population studied had cerebral toxoplasmosis with a prevalence rate of 74.3% and 25.3%) in male and female respectively. A higher prevalence was recorded from the age group >30years without significant difference (X2=0.74, P > 0.05).Conclusion: More research is required to know the exact prevalence of the parasite in this group of individuals since not all the patients were tested.
Correlation Between Total Cholesterol Level with Blood Pressure of Hypertensive Patients in Kalidoni, Palembang
Authors: Umar Tungki Pratama , Mariana Mariana
Published: September 2021

Background: Hypertension is the main problem worldwide. It has strong relationship with other component of metabolic syndrome, namely dyslipidemi. Authors are analyzing the correlation between total cholesterol level and blood pressure in the hypertensive patient at Kalidoni Primary Health Center, Palembang, Indonesia.Methods: This was a cross-sectional study involving 82 adult hypertensive patients. Data were collected from the medical record of patients who are visiting Kalidoni Primary Health Center in December 2019-January 2020. Demographic data, blood pressure, and total cholesterol level were gained. Obtained data are analyzed descriptively (frequency distribution) and analytically (correlation using Pearson or Spearman method).Result: Significant positive correlations were observed between total cholesterol level and systolic blood pressure (r=0.509, p=0.000) in addition to body weight and diastolic blood pressure (r=0.279; p=0.011).Conclusion: Blood cholesterol level had a significant correlation with moderate strength for determining systolic blood pressure level in hypertensive patients.
Gambaran Profil dan Infeksi Cacing Usus pada Pekerja di Tiga Rumah Potong Hewan Provinsi Riau
Authors: Maryanti Esy , Zenia Yola , Aldi Afrinaldi , Mulia Fadly , Linda Mislindawati
Published: September 2021

Background: Intestinal worm infestation is still a health problem in Indonesia that is often neglected. This disease is chronic in nature and is strongly influenced by factors of environmental hygiene and sanitation. Slaughterhouses are places where animals in the form of cows, goat/ sheep and pigs are slaughtered to be distributed to meat sellers or to reataurants. This study aims to determine the profil description and incidence of intestinal worm infestations in workers in three slaughterhouses in Riau Province.Methods: This study was a cross-sectional descriptive study in August – October 2020 in three slaughterhouses in Riau Province ( Pekanbaru, Duri and Dumai city). Stool examination was carried out using the Kato Katz Method at the Parasitology Laboratory Medical Faculty, Universitas Riau. Result: Do A total 37 workers who were examined found 35 men, age range 21 – 30 yo as much as 38% with latest education 46% was high school, length of work 1 – 5 years as much as 57% and as much as 41% have normal nutriotional status. Six workers found positive for intestinal worm infections (16%), there were three hookworm infections and one each to Trichuris trichiura, Oxyuris vermicularis and Hymenolepis diminuta.Conclusion : There were still intestinal worm infections among workers in the three slaughterhouses. Intestinal worm infection usually occurs in children and rarely occurs in adults and if it occurs in adults this may be due to poor hygiene and sanitation of the slaughterhouse workers.
Pengaruh Konsumsi Air dan Keberadaan Fasilitas Sanitasi terhadap Angka Diare pada Anak-Anak di Indonesia
Authors: Fahira Nadia Nasyia , Sihaloho Estro Dariatno , Siregar Adiatma Yudistira Manogar
Published: September 2021

Background: As a developing country, Indonesia maintains a low level of welfare for hygiene, as exemplified by Indonesia’s poor access facilities to clean water and lack of proper sanitation for households. Meanwhile, a proper supply of water and sanitation will help in reducing morbidity and mortality rates of diarrhea in children. Other risk factors such as socio-economic and socio-demographic conditions, helps improving the quality of life of households, thus lowering the risk of various diseases, including diarrhea.Methods: This study uses a Logistic Regression Analysis (Logit) model with Cross-sectional design using data collected from the 5th wave of the Indonesian Family Life Survey (IFLS-5) in 2014. The study population was children aged 2-10 years with a total of 2446 observations.Result: The result shows that there was a relationship between father's education in elementary school level (p=0.013), father's education in junior high school level (p=0.015), father's education in high school level (p=0.001), father's education at the university level (p=0.012), income (p=0.051), children’s age (p=0.000), and children’s gender (p=0.033) with the rate of diarrhea in children.Conclusion: This research concludes that water consumption factors (sources of drinking water, drinking water boiling process before consumption) and sanitation facilities factors (household toilet types) have insignificant results on the diarrhea rate of children in urban areas of Indonesia. However, socio-economic factors (fathers' education and household income) and socio-demographic factors (children’s gender and children’s age) have a significant effect on the diarrhea rates of children in urban areas of Indonesia.
Managing The COVID-19 Pandemic in The Community-Based Mountain Eruption Zone, Cangkringan Sub-District, in Yogyakarta
Authors: Maryanto Maryanto , Tambunan Mangapul Parlindungan , Putra Isranto Handoyo
Published: September 2021

Background: First case in Indonesia was reported in March 2, 2020 and until November, it has infected more than 400.000 people, with more than 300.000 recovered and 15.000 deaths in total. Especially in Cangkringan District and surrounding area, the latest natural disaster is happening in the midst of a COVID-19 pandemic that is eruption of Mount Merapi which encourage local government and outposts to prepare camps for people nearby who suffered from Mount Merapi eruption. Meanwhile, in evacuation camp, the chance of infected by COVID-19 is high and it is a main problem and a purpose of this research.Methods: Methods that is conducted in this research by obtaining vulnerability level data against the outbreak and making a probability map of virus transmission mainly in the eruption red zone.Result: The outcome of this research is COVID-19 mitigation map within eruption red zone of this regency and recommendations about how to control the outbreak among refugees.Conclusion: Therefore, evacuation can be conducted in the midst of pandemic situation because the transmission case is low.
Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner
Authors: Swastika I Nengah Raka , Ristiani Ni Ketut , Gorintha Adrian Wiryanata , Indrayani Agung Wiwiek
Published: September 2021

Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.
The crystal structure of bis(2-oxidopyridin-1-ium-3-carboxylato-κ2
O,O′)-(phenantroline-κ2
N,N′)manganese(II) - methanol (1/3), C27H28N4O9Mn
Authors: Men Xiaoxia , Zhang Zhongyu , Li Xiaoli , Sun Weiqin
Published: September 2021

C27H28N4O9Mn, monoclinic, P21/n (no. 14), a = 10.0269(7) Å, b = 14.1702(10) Å, c = 20.0750(14) Å, β = 100.298(1)°, V = 2806.4(3) Å3, Z = 4, R

gt
(F) = 0.0403, wR

ref
(F
2) = 0.0985, T = 296.15 K.
Neuroscience meets cancer: networks and neuronal input to brain tumors
Authors: Venkataramani Varun , Karreman Matthia A. , Winkler Frank
Published: September 2021

The nervous system with its complex organizational features and functions is well-known for its impressive ability to process information and drive countless biological processes. It has come to the surprise of many that the nervous system can also be intimately involved in an unwelcome area of human life: the initiation and progression of cancer. For brain tumors, the parallels to neurodevelopment and nervous system function can be found on multiple levels. First, cancer cells of incurable gliomas interconnect with long cellular extensions to a large communicating multicellular network. Second, indirect and direct neuronal input can generate, activate, and control brain tumor growth. Third, it is becoming increasingly clear that those features not only drive brain tumor progression but also the notorious resistance of these tumors against standard antitumor therapies. Remarkably, these recent insights have already generated novel ideas for better antitumor therapies.
14N, 13C, and 119Sn solid-state NMR characterization of tin(II) carbodiimide Sn(NCN)
Authors: Jaworski Aleksander , Piątek Jędrzej , Mereacre Liuda , Braun Cordula , Slabon Adam
Published: September 2021

We report the first magic-angle spinning (MAS) nuclear magnetic resonance (NMR) study on Sn(NCN). In this compound the spatially elongated (NCN)2− ion is assumed to develop two distinct forms: either cyanamide (N≡C–N2−) or carbodiimide (−N=C=N−). Our 14N MAS NMR results reveal that in Sn(NCN) the (NCN)2− groups exist exclusively in the form of symmetric carbodiimide ions with two equivalent nitrogen sites, which is in agreement with the X-ray diffraction data. The 14N quadrupolar coupling constant

|

C
Q

|

$\vert {C}_{\text{Q}}\vert $

 ≈ 1.1 MHz for the −N=C=N− ion in Sn(NCN) is low when compared to those observed in molecular compounds that comprise cyano-type N≡C– moieties (

|

C
Q

|

$\vert {C}_{\text{Q}}\vert $

 > 3.5 MHz). This together with the information from 14N and 13C chemical shifts indicates that solid-state NMR is a powerful tool for providing atomic-level insights into anion species present in these compounds. The experimental NMR results are corroborated by high-level calculations with quantum chemistry methods.
DNA methylation profiling reveals new potential subtype‐specific gene markers for early‐stage renal cell carcinoma in Caucasian population
Authors: Liko Alvaro Filbert , Ciputra Edward , Sanjaya Nathaniel Alvin , Thenaka Priskila Cherisca , Agustriawan David
Published: September 2021

Background

Renal cell carcinoma (RCC) is among the top adult cancers worldwide, with a challenging management due to lack of early diagnosis, therapy resistance, and diverse molecular background. Aberrant DNA methylation has been associated with RCC development due to transcription deregulation. We discovered potential DNA methylation‐based biomarkers for stage I RCC in Caucasian population from The Cancer Genome Atlas (TCGA) database.

Methods

Patients’ clinical, methylation beta‐value, and mRNA expression data were retrieved. Differential methylation and expression analysis were conducted to obtain differentially methylated CpG‐gene pairs. Inversely correlated CpG‐gene pairs between their expression and methylation levels were selected using Pearson’s correlation test and then screened for any recorded somatic mutations. Their biomarker capacities were analyzed using the Kaplan‐Meier and receiver operating characteristic analysis, followed by protein network and functional enrichment analysis.

Results

We obtained differentially methylated CpGs in clear cell (KIRC) and papillary RCC (KIRP) but not chromophobe RCC (KICH). Six inversely correlated CpG‐gene pairs with no reported cancer‐associated mutations were selected. Prognostic values were found in ATXN1 and RFTN1 for KIRC, along with GRAMD1B and TM4SF19 for KIRP, while diagnostic values were found in VIM and RFTN1 for KIRC, along with TNFAIP6 and TM4SF19 for KIRP. Both subtypes showed enrichment of immune and metabolism‐related pathways.

Conclusion

We discovered novel potential DNA methylation‐based prognostic and diagnostic markers for early‐stage RCC in Caucasian population. Validation by wet laboratory analysis and adjustments for confounding variables might be needed, considering our study limitation to specific race.
Phytomanagement of a chromium-contaminated soil by a high-value plant: Phytostabilization of heavy metal contaminated site
Authors: Ye Li-Li , Chen Yong-Shan , Chen Yu-Dao , Qian Lian-Wen , Xiong Wen-Li , Xu Jing-Hua , Jiang Jin-Ping
Published: September 2021

Phytoremediation of metal-contaminated soil can be an eco-friendly technology. However, relatively long cultivation times impedes its popularization on a commercial scale. This study evaluated the effectiveness of lavender plants (Lavandula dentata L.) to remediate a highly chromium (Cr)-contaminated site through a pot experiment. The lavender growing soil was mixed both with and without biochar (2.5% w/w) + oyster shell waste (2.5% w/w) and biochar (2.5% w/w) + citrus peel waste (2.5% w/w). The results indicated that Cr(VI) accounted for 19.0% to 4.7% of the total soil Cr, while Cr(III) accounted for 81.0% to 95.3%, from the beginning to the end of the cultivation. The water-soluble Cr concentration decreased from 44.6 mg/kg to 7.5 mg/kg. The biomass of the lavender growing in the contaminated soil decreased by factors in the range between 4-fold and 6-found.The addition of soil amendments significantly reduced the (potential) bioavailable Cr (p < 0.05) in the range of 2 to 3 fold, consequently improving the growth of lavender in the highly toxic soil. In addition, the soil amendments significantly reduced the Cr bioaccumulation and the translocation from the roots to the shoots. These results showed that the cultivation of lavender with suitable amendments can effectively be used for phytomanagement techniques in highly contaminated soil.
Progressive disseminated histoplasmosis in idiopathic CD4 lymphocytopenia an underdiagnosed combination - a case report
Authors: Yadav Prakrati , Kumar Deepak , Bohra Gopal Krishana , Garg Mahendra Kumar , Bharti Jyotsna N , Purohit Abhishek HL , Meena Durga Shankar
Published: September 2021

Progressive disseminated histoplasmosis (PDH) usually presents as fever, anemia, leukopenia, hepatosplenomegaly, lymphadenopathy and pulmonary symptoms. There are few reports showed the association of Idiopathic CD4 lymphocytopenia (ICL) with histoplasmosis. We describe a 65-year-old female presented with history of fever, papulo-nodular rash and significant weight loss and diagnosed as progressive disseminated histoplasmosis. All immunocompromised conditions were ruled out.  In addition, her 2 consecutive CD4 counts were below 300. The patient was diagnosed with PDH associated with ICL. Patient showed significant improvement with liposomal amphotericin B and itraconazole. Absolute CD4 counts should be done in all cases of progressive disseminated histoplasmosis even in HIV negative individuals to rule out associated ICL.
Thyroid carcinoma associated with other primary neoplasms, a single center study
Authors: Gabora Katalin , Bălăcescu Ovidiu , Trifa Adrian , Morariu Ana Maria , Pop Bogdan , Vișan Simona , Fetica Bogdan , Piciu Andra , Piciu Doina
Published: September 2021

Background and aims. Thyroid carcinoma is the most frequent endocrine malignancy. It develops following a complex interaction of environmental and genetic factors. Its incidence is on the rise mostly due to the frequent diagnosis of microcarcinomas (tumor<1 cm ). In most cases, it has very good prognosis and survival rates. The incidence of a second primary malignancy in thyroid cancer patients is higher than in the general population. In this article, we focus on the role of BRAF V600E mutation in the development of other primary neoplasms associated with thyroid carcinoma.

Methods. This study was conducted in the department of Nuclear Medicine and Genetics of the "Prof. Dr. Ion Chiricuță” Institute of Oncology of Cluj-Napoca. We evaluated patients with thyroid carcinoma, who were diagnosed and treated for other malignancies such as breast, colorectal, lung cancer and malignant melanoma. In addition, we tested for the BRAF V600E mutation using paraffin samples of patients.

Results. We identified 17 patients that had thyroid carcinoma associated with other primary malignancies. Two of the patients included in the study had three associated primary cancers. The time interval between the diagnoses of two primary neoplasms in  the same patient was 6.15 years, with a standard deviation (SD) of 5.39 years. The most common primary tumor associated with thyroid carcinoma in this study was breast cancer. We applied genetic testing for the BRAF V600E mutation in 12 patients. The BRAF V600E mutation positivity rate was 26.9% and most of the cancer associations were metachronous (occurring at least 6 months after thyroid cancer).

Conclusions. The BRAF V600E mutation is an important prognostic factor in the neoplasms included in this study, but its presence is not a predictive factor for the appearance of a metachronous or synchronous associated primary neoplasm to thyroid cancer.
Nebaigtų sakinių metodas jaunesniųjų moksleivių tyrimui ir auklėjimui
Authors: Dereškevičius Pranas
Published: September 2021

Straipsnyje aprašoma nebaigtų sakinių metodika – viena iš dažniausiai taikomų vertinant asmenybę ir nuostatas. Analizuojamas metodikos rengimas ir taikymas bandomajame tyrime. Atsižvelgdami į bandomojo tyrimo duomenų preliminarią analizę teigiama, jog nebaigtų sakinių metodas – jautrus instrumentas mokinių nuotaikoms, asmenybei, jos ypatumams tirti – gali būti taikoma kaip papildoma priemonė ir jaunesniųjų moksleivių tarpusavio santykiams, požiūriui į mokyklą, mokytojus ir mokymąsi atskleisti. Nebaigtų sakinių metodas turi tiek diagnostinio lankstumo ir interpretacinės vertės, kiek tyrėjas turi kiekybinės bei kokybinės analizės ir lyginimo, taip pat abiejų procesų vertinimo patirties. Reakcijų į nebaigtus sakinius interpretavimas reikalauja visų pirma gilaus testo psichometrinių ribotumų supratimo, antra, patvirtinančios informacijos iš kitų šaltinių (kaip antai, kiti testai, rašiniai, pokalbiai, stebėjimai), trečia, jautraus sveiko proto tyrėjo praktiko, kuris supranta pašalinių veiksnių ypatumus atsakinėjančiam individui ir tyrimo aplinkai, pripažįsta ir savo paties teorinį šališkumą, o tai gali inicijuoti neteisingas interpretacijas ir veikimo rekomendacijas. Formuluoti teisingas išvadas, remiantis nebaigtų sakinių metodu, galima tada, jei tyrėjas yra įgijęs praktinių įgūdžių daryti pagrįstus sprendimus pagal subjektyvias nuomones.
Mineralogical justification for potentiality of producing marketable hematite products
Authors: Mazhanov Oleh M. , Evtekhov Valeriy D. , Demchenko Oleh S. , Voloshyn Volodymyr M. , Kulyk Yevhen M.
Published: September 2021

Hematite quartzites are a product of weathering of magnetite quartzites, which make up the ferruginous horizons of deposits of the Precambrian banded-iron formation. They occur all over the planet. The largest deposits are found in the iron-producing areas and basins of Central Kazakhstan, the Kursk magnetic anomaly, the Karelian-Kola region, Western Australia, Southeastern India, Brazil, the United States, and Canada. The geological and mineralogical issues of hematite quartzites as raw materials for producing concentrate and sinter ore have been studied most deeply and comprehensively for the deposits of the Kryvyi Rih basin and Central Kazakhstan. However, when developing an effective scheme for producing high-quality metallurgical raw materials, the mineralogical features of hematite ores have been taken into account insufficiently. The aim of the authors of the present work was to study the localization, structure of deposits and mineral composition of hematite quartzites as raw materials for sinter ore and concentrate production. Data from geological observations and mineralogical studies were used as source material. Proven geological, mineralogical, petrochemical methods were used. In accordance with the obtained results, the hematite quartzites are composed of ore-forming (quartz, hematite) and secondary (relict and newly formed) minerals. The total content of the hematite and quartz exceeds 90 mass %. The peculiarity of Ushkatyn III deposit ores is the high content of manganese oxides. The depth of distribution of the weathering crust composed of hematite quartzites varies from 200 to 1000 m. The hematite quartzites’ bodies are characterized by a zonal structure. Their central parts are represented by martite-micaceous hematite, micaceous hematite- martite quartzites; intermediate ones by martite quartzites; peripheral parts – by dispersed hematite-martite, kaolinite-martite-dispersed hematite quartzites. The horizons differ in the quantitative ratio of these varieties. The quantitative ratio of mineral varieties of hematite quartzites, morphology of individuals and aggregates of ore-forming and secondary minerals, their chemical composition and physical properties must be taken into account when developing the optimal technology for the production of high-quality hematite concentrate.
International youth migration: features, tendencies, regulation prospects
Authors: Sardak Sergii E. , Shymanska Kateryna V. , Girman Alla P. , Krupskyi Oleksandr P.
Published: September 2021

The article examines the global and regional issues of international youth migration. The obtained results are most interesting for those regions where the population is shrinking and aging with a rising need to involve youth for educational services and local labor markets, or vice versa, for those losing youth due to their emigration. It is emphasized that youth create an economically active social group, which volume and quality significantly affect the country’s development. During the global migration trends identification, the authors identified the international youth migration flows’ differences and features. The paper notes that the global trends in the international youth migration development include: increase in volume and percentage of youth in the overall number of migrants and the local population; growth of youth migrants in more developed regions and high-income countries; the dominance of migratory centers for youth in Oceania, North America, and Europe; formation of powerful centers of migration of intellectual young labor resources in the UAE, Canada, the USA, Australia, and New Zealand. The available formational policy in youth migration regulation, on the example of India, China, Taiwan, Japan, USA, and Western Europe, is studied. The impact of the COVID-19 pandemic on international migration flows is considered, including changes in international migration in 2020. Based on the UN data analysis on age groups of migrants within geographical regions, it was determined that the prerequisite for such a structure of migration centers is a high level of migratory attractiveness. Such migration-center structure is also explained by the significant level of cross-regional migration, as in the localized regions, their factors of «attraction-repulsion» are formed. It is stressed out that increas- ing military and political instability has led to the uphill of forced youth migrants. The paper proposes the flow optimization directions of international youth migration by formulating the link between migration policy and elements of other integration policies on migrant youth (employment policy, social, educational, information and security policies).
Geoinformation technologies as a basis for research of the optimal location of general secondary education institutions (on the example of Chernivtsi city territorial community)
Authors: Zayachuk Myroslav D. , Kostashchuk Ivan I. , Darchuk Kostiantyn V. , Bilous Yurii O.
Published: September 2021

GIS technologies allow an analyzis of large data sets at the lowest cost. To  date, when forming a network of secondary schools, almost no geographic information  systems have been used. GIS plays a special role in the study of transport and walking  accessibility to GSEI. The article analyzes the theoretical, methodological and practical  problems of using geographic information systems in studies of walking accessibility to general secondary schools of Chernivtsi city  territorial community and describes the general secondary education institutions of the studied community. Based on geoinformation  systems developed in Open Route Service and QGIS, the areas of the community with the best and worst walking accessibility to  secondary schools were identified, which is certainly of great practical importance in creating pivotal institutions, their service zone  and overcoming the problem of overcrowding in some schools. The most convenient location of the general secondary education  institutions of Chernivtsi city territorial community was observed in the central part of the city, as well as in microdistricts Prospect and  Boulevard, where there is a fairly dense arrangement of general secondary education institutions. There are also areas in the community  that are outside the 2-kilometer walking accessibility zone and require transportation for students. Such areas are the Shantsi, Tsetsyno  and Slobidka and Rohizna microdistricts, which have a cottage type accommodations. In general, most of the community is within  walking accessibility. An important aspect of the location of GSEI is the availability indicator, which ranges 0.2 to 0.81. The average  rate of accessibility to GSEI in the Chernivtsi city territorial community is 0.65. It should be noted that in the community there is a  relevant problem of providing students with places in GSEI in those areas, where today the construction of new residential areas is  actively carried out, while educational institutions are not expanding and not being built.
On maintaining the stability of the equilibrium of nonlinear oscillators under conservative perturbations
Authors: Kosov Alexander A.
Published: September 2021

Abstract. The problem of Yu.N. Bibikov on maintaining the stability of the equilibrium position of two interconnected nonlinear oscillators under the action of small, in a certain sense, conservative perturbing forces is considered. With different methods of reducing the system to the Hamiltonian form, some features are revealed for the case when the perturbing forces of the interaction of two oscillators are potential. The conditions for preserving the stability and instability of the equilibrium of two oscillators for the case of sufficiently small disturbing forces are obtained. The problem of maintaining the stability of the equilibrium under conservative perturbations is also considered in the more general situation of an arbitrary number of oscillators with power potentials with rational exponents, which leads to the case of a generalized homogeneous potential of an unperturbed system. The example given shows the applicability of the proposed approach in the case when the order of smallness of the perturbing forces coincides with the order of smallness of the unperturbed Hamiltonian.
A Note on Generating a Power Basis over a Dedekind Ring
Authors: Deajim Abdulaziz , El Fadil Lhoussain
Published: September 2021

In this note, we show that the result [1, Proposition 5.2] is inaccurate. We further give and prove the correct modification of such a result. Some applications are also given.
Heegaard Floer Homology, Degree-One Maps and Splicing Knot Complements
Authors: Bagherifard Narges , Eftekhary Eaman
Published: September 2021

Suppose that K and K' are knots inside the homology spheres Y and Y', respectively. Let X = Y (K, K') be the 3-manifold obtained by splicing the complements of K and K' and Z be the three-manifold obtained by 0 surgery on K. When Y' is an L-space, we use the splicing formula of [1] to show that the rank of

(X ) is bounded below by the rank of

(Y ) if τ(K 2) = 0 and is bounded below by rank(

(Z)) − 2 rank(

(Y)) + 1 if τ(K') ≠ 0.
Dowód z opinii biegłego w postępowaniu uproszczonym ze szczególnym uwzględnieniem nowelizacji k.p.c. wprowadzonej ustawą z dnia 4 lipca 2019 r.
Authors:   Uniwersytet Wrocławski, Polska, Niedźwiecki Mateusz
Published: September 2021

The text presents the issue related to the expert evidence in simplified proceedings. It takes into account the latest amendment to the Code of Civil Procedure introduced by the Act of 4 July 2019 amending the Code of Civil Procedure and certain other acts. Pursuant to the above Act, it was allowed to appoint experts in simplified proceedings by rewording article 505 7 of the Code of Civil Procedure. There are three paragraphs in it, each of which concerns various issues related to obtaining an expert opinion or, with reference to § 1 and § 2, with the resignation from seeking such an opinion. The author analyzes the introduced regulation, referring to the advantages and disadvantages of new solutions. The article also refers to the views expressed in the literature and judicature regarding the discussed issues.