bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Marketing Trends
Authors: Mendonça Pedro , Teixeira Sandrina
Published: May 2022

The pandemic has accelerated the digital transformation, although it has already been underway in recent years. Currently, digitalization can be observed in several sectors, from services to industry, as well as from micro to large companies. Consequently, digital transformation increasingly assumes an essential role in the development of new business models and business growth. The Digital Economy and Society Index (DESI) shows Portugal in 19th place in 2020 which is structurally lower than the European average (within a Europe of 28 countries). Also, a report from the Strategy and Studies Office of the Ministry of Economy and Digital Transition reinforces the lower position of Portugal in the Internet usage rate (71% against 84% of the European Union average). Therefore, Portugal urgently needs to enhance the digital capacity of people and the digital transformation of companies. To face this strategic challenge and take the opportunities and trends that the digital world offers, companies must pay attention to the digital trends. In this respect, following digital trends is essential, namely, to help assess and define the way forward for business digitalization. In fact, technological and digital marketing developments, generally dictate the success of new digital marketing strategies. Although it is difficult to make accurate conjectures in this unpredictable environment (with a pandemic that insists on not ending and with an absurd war underway), the present book aims to point out and analyse some digital marketing trends that might impact the activity of the companies in the digital world in the near future. In practice, the objective of this book is to share with digital marketing specialists a set of different analyses from researchers with distinct backgrounds on the main digital marketing directions that will shape the strategies of the companies. The editors gratefully acknowledge the collaboration of the various authors and the support of the Centre for Social and Organizational Studies (CEOS) and supported by national funds through FCT - Fundação para a Ciência e Tecnologia.
"Look Out the Window": The View of Kyiv
Authors: Zaplatynskyi Vasyl
Published: May 2022

""Look Out the Window": The View of Kyiv" is a feuilleton presenting the reflection of an author experienced during the current Russian-Ukrainian war.
Determination of total protein content in biologicals using biuret method
Authors: Huyen Trang Canh , Thi Cam Le Duong , Thi Lieu Dam , Quang Minh Pham
Published: May 2022

Biuret is one of the methods of protein quantification with many advantages: fast, simple, accurate, suitable for samples with high protein content and purity. In order to convert the method of determining total protein content in biological products with high protein content from Lowry to Biuret method, from April to December 2018, at the Department of Physical Chemical – National Institute for Control of Vaccine and Biologicals, we have conducted an experimental laboratory research methods to evaluate the suitability of the procedure for determining total protein content by Biuret method on two biologicals: IV Globulin and SAR with satisfactory accuracy, precision, robustness, specificity, linearity, limit of quantification LOQ = 0,613 mg; and evaluate the uncertainty (U) of method as required by ISO/IEC 17025:2017, the uncertainty of the IV Globulin sample is 1.78 mg and the SAR sample is 1.85 mg.
The residual H5N1 antibody results and epidemiological characteristics involved on the volunteer group in Ninh Hoa distric
Authors: Van Be Le , Chinh Chien Vien , Huu Thai Duong , Thi Thu Huong Vu , Tan Loc Huynh , Ngoc Nhon Tran , Quynh Chau Ton Nu , Tuong Van Ta Nguyen , Quoc Viet Phu
Published: May 2022

Non-controlled longitudinal study were carry on 185 subjects who received 2 doses of 15µg IVACFLU-A / H5N1 vaccine 21 days apart to determine persistent of antibody-H5N1 and some Epidemiological characteristics involved, the results showed that: 18 months after IVACFLU-A / H5N1 vaccination, the rate of antibody protection (titre ≥ 1/40) still reached 61.6%; GMTs of the injection group reached 49.2. No statically differences on age, gender and epidemiological characteristics related persistent of anti-H5N1 antibody after vaccination. The research is still ongoing until 36 months after vaccination.
Establishment of the national reference for heamophilus influenza type b vaccine
Authors: Thi Kieu Nguyen , Huu Thien Doan , Tuan Dat Do , Thi Cam Le Duong , Huyen Trang Canh , Hoang Long Le , Thi Phuong Do
Published: May 2022

Vietnam still lacks the national standard Hib vaccine to determine the content of Polyribosyl Ribitol Phosphate, an indicator to assess the protective ability of vaccines against the diseases caused by Heamophilus influenza type b (Hib) bacteria. National Institute for Control of Vaccines and Biologicals has developed the specifications of the national standard Hib vaccine, produced a candidate batch, calibrated the candidate to the international standards to determine its value. The results show that the candidate meets the requirements, has been recognized as a national reference standard, namely MCQG.Hib.01, with a content of (5.00 - 5.74) mg PRP/vial.
SUVREMENE NEURORADIOLOŠKE METODE PRIKAZA INTRAAKSIJALNIH TUMORA MOZGA
Authors: Karlović-Vidaković Marijana
Published: May 2022

Primarni tumori mozga predstavljaju aproksimativno 2% od ukupnog broja tumora s godišnjom incidencijom 6-7/100.000 stanovnika u Europi. Najčešći su u dobi 45-70 godina života. U dječjoj dobi čine do 25% od ukupnog broja tumora. Incidencija intraaksijalnih tumora mozga je 2-3/100.000 od kojih su najčešći gliomi, koji čine oko 50% svih gliomskih tumora. Višeslojna kompjuterizirana tomografija (MSCT) prva je dijagnostička metoda izbora kada postoji sumnja na tumor mozga radi njezine široke dostupnosti i kratkog vremena trajanja snimanja. Superiorna je u mogućnosti prikaza intratumorskih kalcifikata kao i destrukcije okolnog koštanog tkiva. Sukladno recentnoj klasifikaciji tumora centralnog nervnog sustava (CNS), karakteristike i stupanj malignosti tumora izravno su povezane s molekularnom biologijom tumorskog tkiva. Stoga je magnetna rezonancija (MR) neuroradiološka metoda izbora u suvremenoj dijagnostici intraaksijalnih tumora mozga koja se koristi upotrebom standardnih i naprednih tehnika snimanja. Mogućnost visoke tkivne diferencijacije i prostorne rezolucije komparativna je prednost MR pretrage, čija je uloga pouzdana dijagnostika i klasifikacija tumora. Uređaji visoke rezolucije poput 3 Tesla MR uređaja, omogućavaju detaljnu analizu tumora, točnu lokalizaciju, identifikaciju granica i anatomskih odnosa tumora s okolnim strukturama, uključujući prikaz vaskulariziranosti tumora i prekida integriteta krvno-moždane barijere, te nazočnost nekroze tumorskog tkiva, intratumorskog krvarenja i intrakranijskog kompresijskog učinka. U novije se vrijeme posebno ističe uloga metaboličkih i funkcijskih dijagnostičkih pretraga poput MR spektroskopije, MR perfuzije,diffusion- weighted imaging (DWI) i diffusion tensor imaging (DTI) koje su sve više zastupljene u prosudbi stupnja malignosti tumorskog tkiva. Navedene neuroradiološke dijagnostičke metode predstavljaju značajan doprinos u planiranju neurokirurškog i onkološkog liječenja i prognozi tumorske bolesti.
IMIDŽING MAGNETNOM REZONANCOM U EVALUACIJI INTRADURALNIH TUMORA KIČME
Authors: Bulja Deniz , Vegar-Zubović Sandra
Published: May 2022

Uvod: Spinalni tumor predstavlja patološku tkivnu masu smještenu unutar kičmene moždine, kičmenog kanala ili vertebralne kolumne. Incidenca primarnih spinalnih tumora je mala i prema navodima iz literature iznosi oko 0,58 do 0,71 na 100.000 pacijenta u godini. Preko dvije trećine svih primarnih spinalnih tumora otpada na tumore intraduralne ekstramedularne lokacije, a ostatak na intraduralne intramedularne tumore. Uvođenjem MRI u kliničku praksu došlo je do revolucije u karakterizaciji spinalnih tumora kroz detaljnu i direktnu vizualizaciju koštane srži i kičmene moždine u više ravni, čime je omogućeno ranije otkrivanje i liječenje kako ekstraduralnih tako i intraduralnih tumora. Iako imidžing putem CT-a daje pouzdane informacije u pogledu procjene matriksa tumora i koštanih promjena kod ekstraduralne lokacije, MRI je metod izbora u procjeni mekotkivne ekstenzije tumora, infiltracije koštane srži i eventualne intraspinalne propagacije. Ciljevi: 1. Prikazati ulogu imidžinga magnetnom rezonancom kod evaluacije intraduralnih spinalnih tumora evaluiranih na Klinici za radiologiju Kliničkog centra Univerziteza u Sarajevu putem predavanja u vidu slikovnog eseja. 2. Klasificirati primarne i sekundarne spinalne tumore u odnosu na njihovo porijeklo iz ekstraduralnog, intraduralnog ekstramedularnog i intraduralnog intramedularnog kompartmenta uz razmatranje dijagnotičkog pristupa u kliničkoj obradi pacijenata s intraduralnim spinalnim tumorima. 3. Pružiti pregled MRI karakteristika različitih primarnih spinalnih tumora intraduralne lokalizacije.
ULOGA MAGNETNE REZONANCE U MENADŽMENTU METASTAZA MOZGA
Authors: Jefić Svjetlana , Marić Daliborka , Kecman Biljana
Published: May 2022

Magnetna rezonanca (MR) je inkorporirana u sve aspekte menadžmenta metastaza mozga. Suprotno klasičnom konceptu koji metastaze mozga tretira kao jedan patološki entitet, novija iskustva pokazuju da se radi se o heterogenoj grupi tumora koji se međusobno razlikuju prema imunohistohemijskoj građi, a posljedično i prema terapijskom odgovoru i u prognostičkom aspektu. Poznavanje puteva širenja, vodećih uzroka metastaza mozga, najčešćih lokalizacija, manje čestih formi (duralne mestastaze, leptomeningealne metastaze, milijarne metastaze, intravaskularna karcinomatoza, “tumor-to-tumor” metastaze), ali i dijagnostičko-terapijskih opcija doprinosi višem stepenu pouzdanosti u definisanju karakterističnog patomorfološkog profila metastaza mozga čime se stvaraju mogućnosti za bolju kontrolu metastatske bolesti. MR je jedinstvena dijagnostička metoda koja omogućava in vivo prikaz strukturalnih, metaboličkih, biohemijskih i funkcionalnih promjena u mozgu. Standardni MR protokol uz aplikaciju paramagnetnog kontrastnog sredstva i takozvane napredne MR tehnike: MR perfuzija (PW-MRI), difuzioni tenzor imaging (DTI), MR spektroskopija (MRS) i funkcionalni MR imaging (fMR) su MR tehnike koje se koriste ne samo za identifikaciju ekspanzivnih masa mozga, već i za procjenu stepena oštećenja tkiva, procjenu rizika kod potencijalne primjene određenih terapijskih procedura kao i za prepoznavanje postterapijskih komplikacija. Intraoperativna upotreba MR za navođenje minimalnih invazivnih procedura daje joj mjesto i na polju terapije. Uloga MR je nezamjenljiva u dijagnostičkom pristupu, u procjeni i odabiru terapijskih procedura, u monitorisanju bolesti i analizi terapijskog odgovora, kao i u prognostičkom postupku.
ZNAČAJ NOVE HISTOMORFOLOŠKE KLASIFIKACIJE TUMORA MOZGA I PRIMJENA U KLINIČKOJ PRAKSI
Authors: Iljazović Ermina
Published: May 2022

Cilj: Tumori mozga predstavljaju intrakranijalne neoplazme unutar samog moždanog parenhima ili centralnog spinalnog kanala. Dobno standardizirana stopa učestalosti ovih tumora bilježi globalan porast od 17,3% između 1990-2016, sa dobno standardiziranom stopom u 2016. od 4,63 na 100 000 osoba godišnje. Zbog brojnih specifičnosti, poput smještaja unutar kranijuma, dobi javljanja, načina rasta, diobe, istraživanje ove vrlo heterogene kategorije i interpretacija samih rezultata nije nimalo jednostavna. Pozadina: Od 1926.g. klasifikacija i terminologija tumora mozga se bazirala prije svega na ćelijskom tipu od koje je tumor nastao te stepenu njene diferencijacije. Od maja 2016. Svjetska zdravstvena organizacija je objavila novu reklasifikaciju tumora mozga koja integrira molekularnu osnovu i informaciju sa histologijom što obezbjeđuje tačniju dijagnozu, bolju prognozu i tretman pacijenta i odgovor na terapiju. U najvećem broju slučajeva, tumori mozga predstavljaju difuzne gliome, različitog histološkog gradusa i uglavnom nepovoljne prognoze zbog njihovog infiltrativnog rasta. Zaključak: Uprkos brojnim pomacima u istraživanju, poboljšanju razumijevanja tumorske biologije, genetskih interakcija, progresije, otkrića onkogenih puteva relativno je malo promjena u cjelokupnoj prognozi i terapijskim opcijama ovog tipa tumora.
ADULT CONGENITAL HEART DISEASE – NEW GUIDELINES AND CLINICAL CARE PERSPECTIVE
Authors: Naser Nabil , Kušljugić Zumreta
Published: May 2022

To date, the prevalence of CHD worldwide is ∼9 per 1000 newborns, with substantial geographic variation. The latest knowledge in the world for the last 50 years about their origin, diagnosis and therapy has contributed to their care. Since adult patients with CHD now present increasing numbers at advanced ages, including the elderly, the term grown-up CHD no longer appears appropriate and was therefore replaced with adult CHD (ACHD) according to the ESC guidelines published in 2020 year. Due to medical, surgical, and technological evolutions over the past decades, >90% of individuals who are born with CHD now survive into adulthood. ACHD represent a challenge for clinicians. Despite optimal medical and surgical treatment, many will experience a progressive decline in cardiopulmonary function leading to advanced heart failure. Severe ventricular dysfunction and/or pulmonary hypertension may not be amenable to corrective repair. Their early recognition and follow-up in adolescence will contribute to better care for these patients. Importantly, the care for ACHD patients is a lifelong process and requires advance care planning strategies.
SISTEMA DE COMPARTILHAMENTO DE DADOS GEOESPACIAIS: SisGEO
Authors: Alvarenga Sylvester Henrique , Vieira Guilherme Souza , Latuf Marcelo de Oliveira , Pagliares Rodrigo Martins
Published: May 2022

O compartilhamento de dados geoespaciais esbarrava, nas décadas passadas, na ineficiente ou até mesmo inexistente infraestrutura de tecnologia de informação. Com o desenvolvimento e a popularização de novos componentes de hardware e software em computadores pessoais, aliados ao investimento na infraestrutura de comunicações, o tráfego de dados obteve um expressivo incremento. Entretanto, diversos dados produzidos por instituições de governo, pesquisa e ensino são de difícil acesso à sociedade até os dias atuais e, com o foco na disponibilização destes, foi desenvolvido o Sistema de Compartilhamento de Dados Geoespaciais, que objetiva compartilhar dados geoespaciais produzidos pelo curso de Geografia da Universidade Federal de Alfenas. A plataforma foi desenvolvida a partir do código-fonte da plataforma TerraBrasilis, desenvolvida pelo Instituto Nacional de Pesquisas Espaciais, que gentilmente colaborou na transferência de tecnologia. As tecnologias utilizadas nesta plataforma são baseadas em softwares de código aberto e seguem as especificações do Open Geospatial Consortium. Passadas as fases de desenvolvimento e implantação, foi possível dar funcionalidade a um WebGIS com desempenho satisfatório, tornando-se públicos, de forma gratuita, dados geoespaciais que servirão à sociedade no suporte à tomada de decisões.
DIFUSÃO ESPACIAL DA COVID-19 EM PEQUENAS CIDADES: MOBILIDADES E RURALIDADES COTIDIANAS
Authors: Cordova Vitor Sartori , Polito Jéssica de Almeida , Marandola Jr Eduardo
Published: May 2022

A difusão espacial da Covid-19 apresenta diferentes proporcionalidades entrelaçadas em relações não lineares, dificultando análises engessadas sobre a pandemia. A prevalência das escalas superiores, no entanto, atravanca a identificação de fatores em âmago local como os modos de vida relacionados a distintas regionalidades. Assim, até que ponto os padrões de densidade demográfica e potencial construtivo de grandes cidades conformam a leitura dos dados sobre os atuais riscos da difusão pandêmica? Desta forma, almeja-se contra argumentar estes padrões através da relevância dos fatores ligados aos modos de vida de populações em contextos regionais além da mobilidade pendular. Se a difusão da Covid-19 está atrelada fortemente à mobilidade, o artigo mostra como esta se apresenta distintamente em pequenas cidades, mesmo consideravelmente urbanizadas, nas quais há significativa presença do modo de vida rural. Serão analisados os municípios de Iracemápolis e Mogi Mirim relacionando-os com as especificidades atreladas à mobilidade cotidiana e a sua reverberação na vulnerabilidade ao vírus.
INSEGURANÇA URBANA E ESTIGMAS SOCIOESPACIAIS EM ARAGUAÍNA-TO
Authors: Sodré Reges
Published: May 2022

A maneira pela qual as cidades são apropriadas no cotidiano é cada vez mais influenciada pela insegurança urbana. Nesse cenário, a cidade é recortada em fragmentos, aos quais são atribuídos sentidos de segurança e insegurança, sendo que os fragmentos percebidos como inseguros são estigmatizados e sobre eles se estabelecem toda sorte de evitamento, distanciamento socioespacial e controle. Nesse trabalho, a partir de entrevistas, levantamento de dados secundários, revisão bibliográfica, visita in loco e mapeamento, discute-se a perversidade do estigma da insegurança em lugares e práticas espaciais de citadinos araguainenses que residem na periferia pobre da cidade. O estigma é constituinte desse espaço, interditando praticas espaciais, aprofundando a segregação e a fragmentação socioespacial, reduzindo a auto-estima e amplificando o individualismo, ancorado, às vezes, a medidas autoritárias, como o endosso a execuções de suspeitos de crimes.
TERMOGRAFIA INFRAVERMELHA EM SOBREVOO OBLÍQUO PARA INDICAR EFEITOS DA VEGETAÇÃO URBANA NA REGULAÇÃO TÉRMICA EM BELÉM, PARÁ
Authors: Costa Anderson Silva , Franco Irving Montanari , Martorano Lucieta Guerreiro , Moraes José Reinaldo da Silva Cabral de
Published: May 2022

Os centros urbanos demandam de maior aporte energético para manter as habitações em conforto térmico em decorrência de alterações atribuídas ao processo de urbanização. O objetivo foi analisar padrões termográficos no Bairro do Marco, na cidade de Belém como estratégia de apontar efeitos da arborização e/ou não em duas avenidas. As imagens termográficas foram obtidas em sobrevoo oblíquo que possibilitou a medição de temperaturas e a observação de padrões de distribuição de calor. Foram analisados alvos nas avenidas mais arborizadas e menos arborizadas. Verificou-se que a diferença entre a temperatura (ΔT) na Av. Almirante Barroso e na Av. Rômulo Maiorana foi de 2,9°C, mas nas duas avenidas foram detectadas diferenças da ordem de 7,4°C. Ao simular na Av. Almirante Barroso sob cenário “de avenida arborizada” considerando-se a diferença média (ΔT) de 2,9°C, os valores obtidos foram inferiores as simulações na Av. Rômulo Maiorana “sem arborização. Conclui-se que a vegetação presta importantes serviços ambientais às populações. Os diagnósticos termográficos apontam indicadores de concentração de calor e/ou áreas com maior atenuação dos raios solares pela vegetação. Os indicadores de regulação térmica pela arborização na Av. Rômulo Maiorana reforçam a importância em manter e/ou adotar canteiros com vegetação arbórea em avenidas de Belém.
Investigando os métodos de avaliação de usabilidade para sistemas colaborativos: uma revisão sistemática da literatura
Authors: Cordova Karine Alessandra , Santos Maria Teresa Silva , Pimentel Claudia , Gasparini Isabela
Published: May 2022

A partir de um mapeamento sistemático da literatura, este artigo busca identificar o cenário atual de métodos de avaliação de usabilidade para sistemas colaborativos. Esse tipo de avaliação torna-se um desafio, pois pode haver problemas que só são identificados em situações de colaboração, uma vez que os métodos utilizados para avaliar sistemas não colaborativos não conseguem explorar esses aspectos. 0 mapeamento foi realizado por meio das bibliotecas digitais totalizando 90 artigos encontrados, e após a aplicação dos critérios de inclusão e exclusão, 15 artigos foram analisados. Os resultados descrevem os métodos alcançados mais utilizados nas avaliações.
Impactos do Isolamento Social provocado pela pandemia de COVID-19 na Relação entre Comunicação Informal e Proximidade Física
Authors: Cardoso Reinaldo , Perin Marcelo G. , Machado Leticia , de Souza Cleidson
Published: May 2022

Este trabalho visa analisar como a relação entre a comunicação informal e a proximidade física foi afetada no contexto da pandemia de COVID-19. A pesquisa foi realizada através de um survey com profissionais de tecnologia da informação com 188 respostas válidas. A análise dos dados mostrou que a proximidade física existente anteriormente à pandemia favoreceu a existência de interações sociais entre os envolvidos, contudo esta proximidade não foi capaz de manter sua relação com a comunicação informal de forma significativa durante a pandemia.
Grupos formados por estudantes ou pelo professor? Uma análise do ponto de vista dos alunos em relação a grupos de estudo
Authors: Gomes Genildo , Conte Tayana , Gadelha Bruno
Published: May 2022

No contexto educacional, e comum que professores utilizem trabalhos em grupo como prática pedagógica para desenvolver nos alunos habilidades sociais que são importantes requisitos no mercado de trabalho. Assim, algumas estratégias de formação de grupos são comuns, como: grupos formados pelos próprios alunos, que podem ser por afinidades ou interesses, e; grupos formados pelo próprio professor de acordo com critérios e objetivos educacionais diversos. Nesse contexto, este artigo apresenta uma análise que considerou essas duas estratégias no contexto de uma disciplina de engenharia de software realizada de modo remoto. Os alunos trabalharam em duas equipes distintas e responderam a um questionario sobre a experiência. Como resultado, verificou-se que apesar dos alunos não terem problemas em trabalhar em grupos formados pelo professor, os maiores níveis de entusiasmo e confiança são observados em membros das equipes formadas pelos próprios alunos.
Die Geburt der Philosophie bei den Griechen
Authors: Held Klaus
Published: May 2022

Mit Denkmitteln der Phänomenologie bei ihrem Begründer E. Husserl und ihrem einflussreichsten Reformer M. Heidegger entwickelt der erste Teil des Buches eine neue Interpretation des Anfangs der Philosophie. Sie bildet das Zentrum eines umfassenden Aufbruchs des Denkens bei den Griechen der Antike und wird begleitet von den ersten Schritten der Wissenschaft und der Einführung der Demokratie. Leitfaden der Interpretation ist die Selbstabgrenzung der frühen Philosophie, deren Grundthema die Welt ist, von der „Doxa“, der vorphilosophischen Denk- und Verhaltensart des Menschen. Vom heutigen ökologischen Interesse an der natürlichen Lebenswelt geleitet erklärt der zweite Teil des Buches phänomenologisch die Entstehung der alteuropäischen Lehre von den vier Elementen.
Die Flüchtlingsthematik in den Medien
Authors: Schenk Michael
Published: May 2022

Using content analyses, this work examines the media tenor in the established print media, the most important TV news programmes and on social media in relation to the topic of refugees, while also investigating the opinions of the population in this respect. It addresses a series of research questions which it answers by means of its empirical analyses. The depiction and accommodation of refugees along with refugee policy are important topics in the study. Moreover, the author examines news frames in the media’s coverage of this issue and, in doing so, identifies their tendency to portray it negatively.
The Quest for a Feasible Utopia
Authors: Guentzel Ralph P.
Published: May 2022

In the wake of Bernie Sanders’ remarkable performance in the 2016 U.S. presidential primaries, democratic socialism captivated the hearts and minds of many voters on both sides of the North Atlantic. Less than a decade later, however, the enthusiasm is gone, and democratic socialism faces an intellectual crisis. This book asks which insights the history of democratic socialism may render to resolve this crisis. For this purpose, it investigates the theories and practices of four democratic-socialist movements: the cooperative one of the 1830s–50s, the collectivist one of the 1900s–20s, the neo-collectivist one of the 1960s–80s, and the participatory one of the 1990s–2010s.
State-of-the-Art Knowledge about 2,4,6-Trichloroanisole (TCA) and Strategies to AvoidCork Taintin Wine
Authors: Tarasov Andrii , Cabral Miguel , Loisel Christophe , Lopes Paulo , Schuessler Christoph , Jung Rainer
Published: May 2022

Cork stoppers have been used for many centuries to seal wine in various vessels. Therefore, corks have become a traditional part of wine packaging in many countries and still play an important role for the entire wine industry. Nowadays, there is a wide option of bottle cork stoppers on the market, such as natural corks, agglomerated and technical stoppers (1 + 1), etc. These cork closures have a number of advantages, including positive sustainable and ecological aspects. Natural cork material can also be responsible for cork taint, which imparts musty/moldy or wet cardboard off-odors to the wine. However, corks are not the only source of cork taint in wine, as will be shown in the present chapter. Over the past decades, a number of compounds have been detected that can contribute to the cork taint. Among them, haloanisoles play a major role, in particular 2,4,6-trichloroanisole (TCA), which has been shown to be responsible for 50–80% or more of musty defect cases in wine. Currently, the cork and wine industries have developed a number of tools and technologies to effectively prevent cork tait in wine or to remove it if the wine is already contaminated. These practical as well as analytical questions about the TCA defects are the subject of the actual chapter.
Revision of the Eurasian species of Aegilips Haliday, 1835 (Hymenoptera: Figitidae: Anacharitinae)
Authors: Mata-Casanova Noel , Selfa Jesús , Pujade-Villar Juli
Published: May 2022

The knowledge of Aegilips in Eurasia is updated. One new species is described: Aegilips insularis Mata-Casanova and Pujade-Villar sp. nov., from Portugal (Madeira). The genus is also cited for the first time in the Indomalayan region with specimens of A. atricornis found in Northern India and Pakistan. Aegilips curvipes Giraud, 1860, Aegilips gemellus Belizin, 1961, Aegilips laevis (Hedicke, 1914), Aegilips montanus Belizin, 1951 and Aegilips punctatus Belizin, 1951 are synonymized with A. nitidulus (Dalman, 1823). Aegilips vena Fergusson, 1985 is synonymized with Aegilips zaitzevi Kovalev, 1974. Aegilips notatus Belizin, 1951, and Aegilips punctulatus Hedicke, 1928 are designated as incertae sedis. The known distributions of A. atricornis, A. kozlovi, A. nitidulus and A. romseyensis are expanded. Morphological differences are discussed and a key for Eurasian Aegilips species is also given.
Comparison of Mid-turbinate Nasal Swabs, Saliva, and Nasopharyngeal Swabs for SARS-CoV-2 Reverse Transcription–Polymerase Chain Reaction Testing in Pediatric Outpatients
Authors: Vos Miriam B. , Gonzalez Mark D. , Stone Cheryl , Cleeton Rebecca , Figueroa Janet , Jerris Robert , Park Sunita I. , Heilman Stacy , Nayee Risha , Chahroudi Ann , Schoof Nils , Mavigner Maud , Morris Claudia R. , Leong Traci , Grindle Amanda , Westbrook Adrianna , Lam Wilbur , Rogers Beverly B.
Published: May 2022

Context.—

Diagnostic testing for SARS-CoV-2 in symptomatic and asymptomatic children remains integral to care, particularly for supporting return to and attendance in schools. The concordance of SARS-CoV-2 detection in children, using various specimen types, has not been widely studied.

Objective.—

To compare 3 sample types for SARS-CoV-2 polymerase chain reaction (PCR) testing in children, collected and tested at a single facility.

Design.—

We prospectively recruited 142 symptomatic and asymptomatic children/young adults into a sample comparison study performed in a single health care system. Each child provided self-collected saliva, and a trained health care provider collected a mid-turbinate nasal swab and nasopharyngeal (NP) swab. Specimens were assayed within 24 hours of collection by using reverse transcription–polymerase chain reaction (RT-PCR) to detect SARS-CoV-2 on a single testing platform.

Results.—

Concurrently collected saliva and mid-turbinate swabs had greater than 95% positive agreement with NP swabs when obtained within 10 days of symptom onset. Positive agreement of saliva and mid-turbinate samples collected from children with symptom onset >10 days prior, or without symptoms, was 82% compared to NP swab samples. Cycle threshold (Ct) values for mid-turbinate nasal samples more closely correlated with Ct values from NP samples than from saliva samples.

Conclusions.—

These findings suggest that all 3 sample types from children are useful for SARS-CoV-2 diagnostic testing by RT-PCR, and that concordance is greatest when the child has had symptoms of COVID-19 within the past 10 days. This study provides scientific justification for using sample types other than the NP swab for SARS-CoV-2 testing in pediatric populations.
Protective personality factors for stress in the elderly during COVID-19 pandemic: A cross-sectional study
Authors: Kilibarda Tatjana , Sinanović Šćepan , Bubanj Saša , Trgovčević Sanja , Ivanović Sunčica , Milutinović Suzana
Published: May 2022

Background/Aim. One of the anti-epidemic measures in the COVID-19 pandemic in 2020 in Serbia was the mandatory complete ban on movement for people over 65 years of age. Two main stress factors affecting their health have been identified: intensive media coverage of the new disease and total physical and even social isolation of the elderly. The aim of this study was to assess the immediate impact of these anti-epidemic measures to combat the COVID-19 epidemic in Serbia on the health of people over 65 years old and to recognize protective factors for their health in the conditions of their obligatory isolation. Methods. The cross-sectional study was conducted on a 20‰ sample of inhabitants over 65 (184 in total) in the urban part of the city of Kruševac, in the central part of Serbia, during April and May 2020. Results. Anti-epidemic measures to combat the COVID-19 epidemic have been associated with deteriorating health in a significantly large proportion of the elderly in the sample (approximately 84%), such as unreasonable fatigue, tension, difficulties performing routine activities due to immobility, concerns, sleeping disorders, and hypertensive episodes. Gender, higher education, and material status were not related to protection and emotional well-being, but some personality factors are related to stress resilience. Conclusion. The protective personality factors for health are the respondents' inclination toward hope, having a purpose in life, faith, optimism, interest, as well a high appreciation of positive emotions in the respondent's life (love, joy, enthusiasm, closeness, and belonging) and having a fulfilled emotional life.
Metaheuristic applications in mechanical and structural design
Authors: Pavlović Goran , Jerman Boris , Savković Mile , Zdravković Nebojša , Marković Goran
Published: May 2022

The paper shows the significance of metaheuristic optimization algorithms through their application to specific engineering problems, especially in mechanical and civil engineering domains, where some significant publications are presented. Moreover, due to their nature, these algorithms are very convenient for application in various engineering examples, both with single-objective or multi-objective optimization problems. Also, they are successfully being applied for tasks with a great number of variables and constraint functions. Finally, the paper presents the comparison of the results of seven chosen metaheuristic optimization algorithms that were applied on the example of the canti-lever beam subjected to complex loading. The objective function was the cross-sectional area of the welded I-profile. In contrast, the constraint functions were the permissible stresses in the I-profile and the welded connection supporting a cantilever beam and one welding technology limitation. After comparing obtained optimum results, optimization time and convergence for all seven chosen algorithms, some conclusions and recommendations for an appropriate type choice and application were made.
Sensitivity of a simple earthquake nucleation model to small parameter perturbation: Conditions for the occurrence of deterministic chaos
Authors: Kostić Srđan , Vasović Nebojša , Trivan Jelena
Published: May 2022

A new mechanism that may account for the onset of chaotic dynamics of earthquake faults is proposed and analyzed. The concept is to build on the Burridge-Knopoff model, which integrates the spring-block setup with the Dieterich-Ruina's rate- and state-dependent friction law to interpolate for the key aspects of earthquake episodes, including the seismic nucleation, fracture propagation and arrest, as well as the rupture healing. Results obtained indicate that deterministic chaos occur in case frictional parameters exhibit small oscillations about their equilibrium values. Based on the construction of appropriate phase portraits, power spectra and the Lyapunov exponents it could be concluded that a single time-dependent parameter is sufficient for the chaotic behavior to emerge, while the fully developed chaos is found when two perturbed parameters are brought into play.
Corpo e (des) fragmentação do discurso
Authors:   Universidade do Estado de Santa Catarina, Santos Geisa Lima dos
Published: May 2022

O artigo discorre acerca de questões referentes ao corpo e a (des) fragmentação do discurso, a partir da leitura dos textos “A mortificação do corpo em é isto um homem? De Primo Levi” e “Surrealismo, mito e psicanálise”. Através dos conceitos sobre simulacro, fetiche, o mito de gradiva, a ideia da mulher como musa e artista, vão sendo realizadas problematizações mostrando que o corpo e principalmente o corpo feminino no campo da arte e da vida foi/é violado de várias formas; e que o debate sobre esse espaço é necessário para a construção/desconstrução de imaginários e discursos no âmbito social e artístico, ou seja, é preciso romper com a produção de signos e consequentemente de subjetividades falocêntricas, racistas, eurocêntricas, através de manobras e articulações artísticas pensando no corpo da mulher como produtor do corpo social.
Um olhar sobre o tempo: [Entre] coleções e fotografias
Authors:   Universidade do Estado de Santa Catarina, Silva Tharciana Goulart da
Published: May 2022

O ato de desenvolver coleções acompanha a condição humana. É a curiosidade e o desejo que move o seu fazer. Colecionar é salvaguardar, transpor o objeto escolhido para um novo contexto e ordem. A fotografia, como habitualmente conhecida, vai ao encontro da ideia de coleção, de algo que auxilia na permanência da memória.
A importância das Artes Visuais na aprendizagem das crianças
Authors: Fogliarini Moura Eliane Maria , Wolff Paim Marilane Maria
Published: May 2022

O processo de construção da arte avançou muito até chegar às salas de aula como expressão da linguagem e papel fundamental de transformação humana para então contribuir significativamente para o desenvolvimento cognitivo, motor e afetivo da criança, além de possibilitar a sua expressão e a percepção de mundo. A importância de se trabalhar com as Artes Visuais na rotina escolar: desenho, pintura, modelagem, recorte e colagem, contribui para a caracterização das diferentes linguagens no processo de aprendizagem, possibilitando o desenvolvimento das emoções e a estrutura para a escrita. Para tanto, o desenho traz em seu conteúdo a expressão do pensar e do sentir da criança, o desenvolvimento motor e aquisições do seu relacionamento com o meio social. Assim, é importante compreender de que maneira a linguagem artística contribui para a aprendizagem da criança, identificar as possíveis metodologias que podem ser trabalhadas e relacionar a interação da criança com o mundo que a cerca.
Família, educação artística e contrato natural: o valor da arte e da família na educação do património natural
Authors: Caeiro Rodríguez Martín
Published: May 2022

Há o que tem sido chamado de "défice de natureza" nas gerações actuais devido à falta de contacto com os ambientes naturais. Ligados a isto, encontramos conceitos como "inteligência naturalista" e "património natural". O objectivo deste trabalho é analisar as implicações que a família tem na educação dos seus filhos e como parte activa do sistema educativo na sensibilização para o património natural e o ambiente. Com base na Investigação Educativa Baseada nas Artes e na Pedagogia Andante, educação patrimonial e autoetnografia visual, apresentamos diferentes experiências que sensibilizam para o valor da família na educação patrimonial natural e no que Michel Serres chamou de "contrato natural": um compromisso que todos devemos assumir ao nascer para o planeta que habitamos. Estas experiências familiares para a educação do património natural são realizadas a partir da dupla condição do investigador de ser pai e educador artístico numa Faculdade de Educação, e de ter a responsabilidade de educar futuros professores para trabalharem com os seus alunos no respeito pelo ambiente, apreciação pelos espaços naturais e pelo património natural.
Radikaliseringens religiøse dimensioner
Authors: Larsen Jeppe Fuglsang , Jensen Sune Qvotrup
Published: May 2022

Empirisk forskning i radikal islamisme viser, at radikale islamister oftest selv forstår deres verdenssyn, handlinger og motiver som dybt religiøse. Alligevel har forskere ofte nedtonet de religiøse dimensioner af radikalisering. Denne artikel argumenterer for, at der ikke er nogen vej uden om at forsøge at forstå de religiøse dimensioner af radikal islamisme, da det er dem, der giver radikale islamister en følelse af meningsfuldhed og retning i livet, hvorfor de er centrale i deres radikaliseringsprocesser. For at forstå de religiøse dimensioner af radikaliseringsprocesser præsenterer og diskuterer artiklen to teoretiske perspektiver som hidtil ikke har været anvendt i radikaliseringsforskningen, nemlig everyday religion-perspektivet og sociology of religious emotions. Det er perspektiver på religion, der kan være med til at belyse de religiøse dimensioner af radikalisering ved at fokusere på aktørernes subjektive selvforståelser og følelser. Artiklen viser gennem interviews med tidligere radikale islamister, at religion spillede en central rolle i deres hverdag og selvforståelse, mens de var en del af radikale islamistiske grupper. Dermed illustreres frugtbarheden af de to anvendte teoretiske perspektiver.
Mönster i rappakaljan
Authors: Svensson Jonas
Published: May 2022

Föreliggande artikel är resultatet av ett test som undersöker om det går att använda ett högst bristfälligt resultat av automatisk transkribering via Googles tjänst Speech-to-Text av 208 inspelade föreläsningar hämtade från den svenska salafistiska hemsidan Islam.nu för att finna återkommande mönster. Syftet är att få en översikt över innehållet i ett material som är både omfattande och i sitt ursprungsformat svåröverskådligt. Artikeln är en genomgång steg för steg av en process som kombinerar datorassisterade metoder för fjärrläsning och nätverksanalys. Experimentets resultat tyder på att datorassisterad analys av automatiskt transkriberade texter kan fylla en funktion framför allt som en del i en process att identifiera relevant material för djupstudier.
Retail Sales Forecasting Using Deep Learning: Systematic Literature Review
Authors:   Institute of Applied Computer Systems, Riga Technical University,  Meza 1 k1, Riga, LV-1048, Latvia, Eglite Linda , Birzniece Ilze ,   Institute of Applied Computer Systems, Riga Technical University,  Meza 1 k1, Riga, LV-1048, Latvia
Published: May 2022

This systematic literature review examines the deep learning (DL) models for retail sales forecast. The accuracy of a retail sales forecast is a prevalent force for uninterrupted business operations. Accuracy for retailers means limiting supply chain and storage costs, ensuring no product is out of stock, and facilitating smooth promotional operations. The study analyses the DL frameworks used in reviewed literature. Tested DL models are listed, as well as other machine learning and linear models used for the evaluation comparison. Additionally, the review presents the metrics used by the authors for the model evaluation. This article concludes by describing the benefits and limitations of DL models for sales forecasting.
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies
Authors: Hwang Justin H , Arafeh Rand , Seo Ji-Heui , Baca Sylvan C , Ludwig Megan , Arnoff Taylor E , Sawyer Lydia , Richter Camden , Tape Sydney , Bergom Hannah E , McSweeney Sean , Rennhack Jonathan P , Klingenberg Sarah A , Cheung Alexander TM , Kwon Jason , So Jonathan , Kregel Steven , Van Allen Eliezer M , Drake Justin M , Freedman Matthew L , Hahn William C
Published: May 2022

Metastatic castration-resistant prostate cancers (mCRPCs) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ARTs). Our previous work identified CREB5 as an upregulated target gene in human mCRPC that promoted resistance to all clinically approved ART. The mechanisms by which CREB5 promotes progression of mCRPC or other cancers remains elusive. Integrating ChIP-seq and rapid immunoprecipitation and mass spectroscopy of endogenous proteins, we report that cells overexpressing CREB5 demonstrate extensive reprogramming of nuclear protein–protein interactions in response to the ART agent enzalutamide. Specifically, CREB5 physically interacts with AR, the pioneering actor FOXA1, and other known co-factors of AR and FOXA1 at transcription regulatory elements recently found to be active in mCRPC patients. We identified a subset of CREB5/FOXA1 co-interacting nuclear factors that have critical functions for AR transcription (GRHL2, HOXB13) while others (TBX3, NFIC) regulated cell viability and ART resistance and were amplified or overexpressed in mCRPC. Upon examining the nuclear protein interactions and the impact of CREB5 expression on the mCRPC patient transcriptome, we found that CREB5 was associated with Wnt signaling and epithelial to mesenchymal transitions, implicating these pathways in CREB5/FOXA1-mediated ART resistance. Overall, these observations define the molecular interactions among CREB5, FOXA1, and pathways that promote ART resistance.
Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells
Authors: Beon Jiyoon , Han Sungwook , Yang Hyeokjun , Park Seung Eun , Hyun Kwangbeom , Lee Song-Yi , Rhee Hyun-Woo , Seo Jeong Kon , Kim Jaehoon , Kim Seyun , Lee Daeyoup
Published: May 2022

Inositol polyphosphate multikinase (IPMK), a key enzyme in inositol polyphosphate (IP) metabolism, is a pleiotropic signaling factor involved in major biological events, including transcriptional control. In the yeast, IPMK and its IP products promote the activity of the chromatin remodeling complex SWI/SNF, which plays a critical role in gene expression by regulating chromatin accessibility. However, the direct link between IPMK and chromatin remodelers remains unclear, raising the question of how IPMK contributes to transcriptional regulation in mammals. By employing unbiased screening approaches and in vivo/in vitro immunoprecipitation, here we demonstrate that mammalian IPMK physically interacts with the SWI/SNF complex by directly binding to SMARCB1, BRG1, and SMARCC1. Furthermore, we identified the specific domains required for IPMK-SMARCB1 binding. Notably, using CUT&RUN and ATAC-seq assays, we discovered that IPMK co-localizes with BRG1 and regulates BRG1 localization as well as BRG1-mediated chromatin accessibility in a genome-wide manner in mouse embryonic stem cells. Together, these findings show that IPMK regulates the promoter targeting of the SWI/SNF complex, thereby contributing to SWI/SNF-meditated chromatin accessibility, transcription, and differentiation in mouse embryonic stem cells.
FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells
Authors: Zhang Yanchun , Xiong Xuexue , Zhu Qi , Zhang Jiali , Chen Shengmiao , Wang Yuetong , Cao Jian , Chen Li , Hou Linjun , Zhao Xi , Hao Piliang , Chen Jian , Zhuang Min , Li Dake , Fan Gaofeng
Published: May 2022

Tyrosine phosphorylation, orchestrated by tyrosine kinases and phosphatases, modulates a multi-layered signaling network in a time- and space-dependent manner. Dysregulation of this post-translational modification is inevitably associated with pathological diseases. Our previous work has demonstrated that non-receptor tyrosine kinase FER is upregulated in ovarian cancer, knocking down which attenuates metastatic phenotypes. However, due to the limited number of known substrates in the ovarian cancer context, the molecular basis for its pro-proliferation activity remains enigmatic. Here, we employed mass spectrometry and biochemical approaches to identify insulin receptor substrate 4 (IRS4) as a novel substrate of FER. FER engaged its kinase domain to associate with the PH and PTB domains of IRS4. Using a proximity-based tagging system in ovarian carcinoma-derived OVCAR-5 cells, we determined that FER-mediated phosphorylation of Tyr779 enables IRS4 to recruit PIK3R2/p85β, the regulatory subunit of PI3K, and activate the PI3K-AKT pathway. Rescuing IRS4-null ovarian tumor cells with phosphorylation-defective mutant, but not WT IRS4 delayed ovarian tumor cell proliferation both in vitro and in vivo. Overall, we revealed a kinase-substrate mode between FER and IRS4, and the pharmacological inhibition of FER kinase may be beneficial for ovarian cancer patients with PI3K-AKT hyperactivation.
Method for Aerosol Particle and Gas Analyses based on Dual-channel Mid-infrared Sensor
Authors: Kim Soocheol , Park Soyoung , Lee Kangbok
Published: May 2022

Although researchers are actively investigating methods to improve fire detector performance, few studies have investigated fire detectors that detect the type of fire. Fire type detection serves a key role in quickly extinguishing fires and preventing their spread. We present a non-dispersive infrared (NDIR)-based dual-channel mid-infrared (mid-IR) method that can detect and classify aerosol particles and gases. 4.2 μm and 4.7 μm mid-IR light emitting diodes (LEDs) light sources with strong absorption for CO2 and CO are employed. and, and the mid-IR LEDs are modulated with 900 Hz and 1,000 Hz, respectively to increase the signal-to-noise ratio and reduce interference between the light sources. The modulated lights pass through the lenses and sample, and are acquired by a photodetector. The transmittances of the 4.2 μm and 4.7 μm lights are measured to detect the aerosol particles and gases, and the aerosol particles and gases are classified via hierarchical clustering using the measured transmittances and the ratio between the measured transmittances. Various aerosol particles and gases are detected by measuring the transmittance, and the aerosol particles and gases are classified by calculating the distance between clusters. Spectral transmittances analysis of different wavelength bands will enable the detection of various aerosol particles and gases, and further improve the classification accuracy. Furthermore, this method can be applied to fire detection to develop a highly useful technique that can detect and classify fire smoke and rapidly detect the type of fire.