bluuebunny/crossref_metadata_2025 huggingface dataset:
A percepção do usuário em relação à qualidade do atendimento na atenção primária à saúde
Authors: Morais Isabella Cristina Oliveira , Padilha Leticia Aparecida Resende , Vaz Nathália Resende Pereira , Nogueira Renata Licursi
Published: June 2020

Objetivo: Avaliar os atributos referenciados pelos princípios e diretrizes do Sistema Único de Saúde (SUS) sob a perspectiva dos usuários para mensurar a qualidade dos serviços oferecidos, evidenciando assim, o nível de conhecimento sobre o assunto. Métodos: Estudo analítico, transversal, cujos dados foram colhidos pela aplicação do questionário PCATool – Brasil, em usuários aleatórios nas salas de espera de cinco Unidades Básicas de Saúde da cidade de Franca-SP, totalizando 100 entrevistados. Resultados: Nas unidades avaliadas, o número de mulheres entrevistadas foi maior do que o de homens e a idade predominante variou em torno de 38 anos. Em relação aos atributos, não foram encontradas diferenças significativas entre os escores. O pior escore encontrado foi a Integralidade - dimensão serviços prestados- e o único atributo orientado para Atenção Primária à Saúde (APS) foi o acesso de primeiro contato. Conclusão: Há necessidade de melhorar o acesso da população aos serviços de saúde e reforçar a importância da educação e conscientização sobre o funcionamento da APS, para que os usuários tenham melhor entendimento desta como porta de entrada do SUS, fortalecendo, assim, os objetivos fundamentais deste sistema: promover saúde e prevenir doenças.
La música dentro de las cortes europeas del siglo XVI. El modelo de Il Cortegiano y el papel de las damas en su consolidación. El ejemplo de las cortes italianas
Authors: Comellas Solé Jordi
Published: June 2020

Durante el siglo XVI las élites nobiliarias tomaron como modelo de comportamiento al gentiluomo descrito por Baldassare de Castiglione en su Cortegiano. Según este ideal, la música jugaba un papel esencial en la formación de príncipes y cortesanos. El soberano humanista debía conjugar la doble faceta de intérprete y patrón. Paradójicamente y bajo este prisma, en las cortes italianas de Mantua y Ferrara la figura de la mujer adquirió una relevancia especial en dos ámbitos, por un lado en el intenso patronazgo musical ejercido por las princesas de las familias gobernantes, y por otro en la importancia de las cortesanas y profesionales como intérpretes. Todo ello posibilitó el desarrollo de un estilo de canto de gran refinamiento y de un virtuosismo extremo, explicitado en el concerto delle dame de la corte estense de Ferrara de finales del siglo XVI.
Encarar el miedo: Don Francisco Fernández de la Cueva, VIII duque de Alburquerque (1619-1676), Virrey de Nueva España y de Sicilia; sobre su estancia en Flandes y su retrato por los hermanos Michaelina y Charles Wautier.
Authors: Sanzsalazar Jahel
Published: June 2020

El presente artículo desvela la identidad y autoría de un Retrato de Caballero desconocido que estuvo atribuido al círculo de Velázquez. En base a la peculiar fisionomía del retratado y al parecido con otros retratos conocidos, se identifica al personaje con Don Francisco Fernández de la Cueva, VIII duque de Alburquerque (1619-1676), Virrey de Nueva España (1653-1660) y de Sicilia (1668-1670). Alburquerque estuvo en Flandes entre 1640 y 1643, periodo durante el cual habría sido retratado por los hermanos Michaelina y Charles Wautier, a quienes se restituye la pintura tanto por razones estilísticas e históricas como por la evidencia de los restos de una firma en la parte superior izquierda del lienzo. El texto traza la carrera de este personaje ligado a la historia de España, Flandes, México y Sicilia, destacando su inclinación a las Bellas Artes y adentrándose en su polémica participación en la Batalla de Rocroi en 1643.
Un lienzo inédito de Francisco Barrera (1595-1658): apuntes sobre pintura ridícula en la España del siglo XVII
Authors: Hervás Crespo Gonzalo
Published: June 2020

El presente artículo da a conocer una pintura ridícula de Francisco Barrera, que ayuda a contextualizar otro tipo de obras anónimas de similar factura, y comprender mejor las estrategias comerciales que algunos artistas siguieron en el Madrid de la primera mitad del siglo XVII.
Kontribusi Peran Orangtua dan Guru dalam Pembentukan Karakter Islami Anak Usia Dini
Authors: Wahyuni Ida Windi , Putra Ary Antony
Published: June 2020

PAUD Sekato merupakan lembaga PAUD dengan kurikulum umum, namun lingkungan daerah tersebut penduduknya mayoritas beragama Islam, materi pendidikan agama Islam hanya diberikan dalam materi umum untuk menunjang pemahaman siswa secara sederhana. Tujuan penelitian adalah untuk mengetahui kontribusi peran orang tua dan guru dalam pembentukan karakter Islami serta faktor-faktor yang mempengaruhinya. Penelitian ini menggunakan metode penelitian deskripstif kualitatif. Subyek penelitian yaitu orang tua, guru dan kepala sekolah PAUD Sekato Desa Mandiangin, Kecamatan Minas Kabupaten Siak. Penelitian ini memaparkan hasil wawancara, observasi dan dokumentasi yang mendalam untuk dibuat kesimpulan. Hasil penelitian menunjukkan bahwa kontribusi peran orang tua dan guru dalam pembentukan karakter Islami siswa PAUD Sekato dengan mengajarkan menerapkan nilai-nilai karakter yang berlandaskan Islam, dan memantau perkembangan siswa, (2) Faktor yang mempengaruhinya adalah dukungan orang tua, kedisiplinan, profesionalisme guru, keteladanan, dan media sosial. Sedangkan faktor penghambatnya, adalah media massa, belum terselenggaranya program parenting, ada sebagian siswa yang lingkungannya tidak menceriminkan karakter Islami.
Transport Mechanisms Underlying Ionic Conductivity in Nanoparticle-Based Single-Ion Electrolytes
Authors: Kadulkar Sanket , Milliron Delia , Truskett Thomas , Ganesan Venkat
Published: June 2020

Recent studies have demonstrated the potential of nanoparticle-based single-ion conductors as battery electrolytes. In this work, we introduce a coarse-grained multiscale simulation approach to identify the mechanisms underlying the ion mobilities in such systems and to clarify the influence of key design parameters on conductivity. Our results suggest that for the experimentally studied electrolyte systems, the dominant pathway for cation transport is along the surface of nanoparticles, in the vicinity of nanoparticle-tethered anions. At low nanoparticle concentrations, connectivity of cationic surface transport pathways and conductivity increase with nanoparticle loading. However, cation mobilities are reduced when nanoparticles are in close vicinity, causing conductivity to decrease for suffciently high particle loadings. We discuss the impacts of cation and anion choice as well as solvent polarity within this picture and suggest means to enhance ionic conductivities in single-ion conducting electrolytes based on nanoparticle salts.
An Alternating Quark Sequence Subnucleonic Structure of Stable Light Nuclei H-1 Through C-13
Authors: Walsh Raymond
Published: June 2020

The proposed structures of stable nuclei of H-1 through C-13 incorporate an alternating up and down quark sequence (AQS) of equally spaced quarks around regular geometries. AQS nuclear models represent quark positions in the same way molecular ball and stick models represent the relative positions of atoms. In AQS, the ball identifies the center of quark mass and the stick length is constant and equal to the most recent radius of the proton (0.8414 fm). AQS radius predictions use current quark masses, and predictions for H-1 to C-13 demonstrate 99.3% average agreement (SD 4%) and statistical correlation of ρ = 0.96, p<0.001, with accepted RMS charge radii. These results compare favorably to a close-packed nucleons model and a spherical nucleus model. A set of AQS parameters is included. Light nuclei tend to form ring structures corresponding to regular polyhedra, the smallest of which is the dodecagon structure of helium-4. Opposite quarks link nucleons to maintain a continuous sequence of alternating equally spaced quarks. Quark sequences may overlap so that protons overlap with neutrons. The more regular polyhedron structures of light nuclei yield better AQS radius predictions, whereas larger nuclei tend to be less regular and are thus less predictable (with the exception of the double overlapping octadecagon structure for the 36 quarks of C-12). The relative certainty in the accepted radius of helium-4, and its geometric relationship to the proton radius, allow a geometric solution to the “proton puzzle” yielding an AQS prediction for the proton radius of 0.8673±0.0014 fm.
NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy
Authors: sun zhihong , Deng Guanjun , Peng Xinghua , Xu Xiuli , Liu Lanlan , Xu Zhen , Ma Yifan , Zhang Pengfei , Gong Ping , Cai Lintao
Published: June 2020

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.
A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely
Authors: Suhail Mohd.
Published: June 2020

It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. Thispositive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemicsituation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquineand (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.
Benchmark Assessment of Molecular Geometries and Energies from Small Molecule Force Fields
Authors: Lim Victoria T. , Mobley David
Published: June 2020

Force fields are used in a wide variety of contexts for classical molecular simulation, including studies on protein-ligand binding, membrane permeation, and thermophysical property prediction. The quality of these studies relies on the quality of the force fields used to represent the systems. Focusing on small molecules of fewer than 50 heavy atoms, our aim in this work is to compare six force fields: GAFF, GAFF2, MMFF94, MMFF94S, SMIRNOFF99Frosst, and the Open Force Field version 1.0 (Parsley) force field. On a dataset comprising over 26,000 molecular structures, we analyzed their force field-optimized geometries and conformer energies compared to reference quantum mechanical (QM) data. We show that most of these force fields are comparable in accuracy at reproducing gas-phase QM geometries and energetics, but that GAFF/GAFF2/Parsley do slightly better in reproducing QM energies and that MMFF94/MMFF94S perform slightly better in geometries. Parsley shows considerable improvement over its predecessor SMIRNOFF99Frosst, and we identify particular outlying chemical groups for further force field improvement.
Degradation of Pharmaceuticals Through Sequential Photon Absorption and Photoionization – the Case of Amiloride Derivatives
Authors: Jorner Kjell , Rabten Wangchuk , Slanina Tomas , Proos Vedin Nathalie , Sillén Sara , Wu Ludvigsson Jufang , Ottosson Henrik , Norrby Per-Ola
Published: June 2020

Photodegradation of pharmaceutical and agrochemical compounds is an important concern for health and the environment. Amiloride derivatives undergo clean photosubstitution in protic solvents. We have studied this apparent photo-SNAr reaction with a range of experimental and computational techniques. Available evidence points to a mechanism starting with photoexcitation followed by absorption of a second photon to eject an electron to give a radical cation intermediate. Subsequent substitution reaction with the protic solvent is assisted by a general base, possibly strengthened by the proximal solvated electron. Final recombination with the solvated electron generates the observed product. Quantum chemical computations reveal that excited state antiaromaticity is relieved when an electron is ejected from the photoexcited molecule by the second photon, leading to a weakly aromatic radical cation. The mechanism indicated here could have wide applicability to photoinduced degradation of similar heteroaromatic compounds in the environment as well as in protic solvents. There are also strong similarities to a class of increasingly popular synthetic photoredox methods.
A Fluorogenic Heparan Sulfate Disaccharide for the Measurement of Heparanase Activity
Authors: Wu Liang , Wimmer Norbert , Ferro Vito , Davies Gideon J.
Published: June 2020

The endo-β-glucuronidase heparanase mediates mammalian heparan sulfate catabolism, and is of considerable medical interest due to its prominent role in cancer aggression and metastasis. Biochemical studies of heparanase are currently hampered by a lack of suitable chromogenic or fluorogenic assay substrates, instead relying on lengthy multistep procedures to measure activity. Herein, we demonstrate that N’,6-O’-bis-sulfated 4-methylumbelliferyl heparan sulfate disaccharide is a competent fluorogenic heparanase substrate. Despite somewhat slow turnover, the high sensitivity of 4-methylumbelliferyl fluorescence provides a wide signal window that enables both enzyme turnover and inhibition kinetics measurements. Crystal structures with heparanase also provide the first ever observation of a substrate in an activated 1S3 conformation, highlighting previously unknown interactions involved in turnover. Our results pave the way for the design of further improved HPSE substrates that may enable rapid assessment of enzyme activity, which in turn will drive development of new heparanase inhibitors for therapeutic use.
Pengembangan sistem otomatisasi pembangkitan kasus uji dengan algoritma genetika dan test case generation method
Authors: Setyawan Moh Arsyad Mubarak , Pradana Fajar , Priyambadha Bayu
Published: June 2020

Pengujian perangkat lunak merupakan salah satu bagian penting dari pembuatan perangkat lunak. Pada pengujian perangkat lunak terdapat pengujian unit. Pengujian unit merupakan proses pengujian komponen yang berfokus untuk memverifikasi unit terkecil pada perancangan perangkat lunak. Pada tahap pengujian unit terdapat proses pembangkitan kasus uji. Selama ini, pembangkitan kasus uji dari suatu kode program dilakukan secara manual se-hingga membutuhkan waktu yang lama. Hal ini dikarenakan banyaknya kemungkinan jalur pada kode sumber yang akan diuji.  Dalam penelitian ini dibangun suatu sistem otomatis untuk membangkitkan kasus uji. Alur kerja sistem dimulai dari analisa kode sumber dengan Spoon Library, selanjutnya dibentuk CFG (Control Flow Graph) dan DDG (Dynamic Directed Graph). Dari DDG tersebut akan dibangkitkan jalur layak yang terdapat pada DDG, dengan menggunakan algoritma genetika diharapkan dapat mengoptimalkan penentuan jalur independen. Dari masing-masing jalur independen akan dibangkitkan kasus ujinya dengan metode test case generation. Pengujian akurasi sistem pada sistem otomatisasi pembangkit kasus uji dengan jumlah populasi 5, 10 dan 15 serta jumlah maksimum generasi 50, 100, 200 dan 250 dihasilkan jumlah populasi paling optimal yaitu 10 dan maksimum generasi optimal yaitu 200 dengan akurasi 93,33%. Pada jumlah populasi dan maksimum generasi sesudahnya tidak terjadi peningkatan akurasi yang signifikan. Tiap peningkatan jumlah populasi dan maksimum generasi dapat meningkatkan akurasi sistem.  Software testing is one of the most important part of making software. On the software testing there are unit testing. Unit Testing is a process for verifying component, focusing on the smallest unit of software design. In the unit testing phase contained test case generation process. During this time, the generation of test cases of a program code is done manually. In this study, constructed an automated system to generate test cases. The workflow system starts from the analysis of the source code with the library spoon and then create CFG (Control Flow Graph) and DDG (Dynamic Directed graph). From the DDG will be raised feasible path using a genetic algorithm. Furthermore, from fea-sible path sought independenth path which is a path base d on the level of uniqueness of the path to the other path. From each independenth path raised the test case with a test case generation method. Testing accuracy of the system on the automation system generating test cases with populations of 5,10 and 15 as well as the maximum number of generations 50, 100, 200 and 250 produced the most optimal population number is 15 and the most optimal maximum generation is 200 with accuracy 93.33%. Each increase in the number of population and maximum generation can improve the accuracy of the system. Level accuracy with population number over 10 and maximum generation over 200 has no increace accuracy significant.
Party Foot-Soldiers, Quasi-Militias, Vigilantes, and the Spectre of Violence in Zimbabwe’s Opposition Politics
Authors: Moyo Charles
Published: June 2020

Scholarship tends to neglect the phenomenon of political violence in opposition parties in Zimbabwe. The prevailing narrative is that political violence is largely a monopoly of the state and the ruling party, Zimbabwe African National Union – Patriotic Front (ZANU-PF). However, an emerging trend implicates opposition political parties, particularly the Movement for Democratic Change (MDC). The MDC’s party’s foot-soldiers, especially the “Vanguard,” often exhibit violent tendencies. Accordingly, the present article explores the scourge of intra-party violence in the opposition party MDC between 2005 and 2019. The article conceptualises and contextualises MDC’s violence through the lenses of Zimbabwe’s political culture and socialisation in the context of the country’s pre-colonial, colonial, and postcolonial historical trajectories.
DESIGN OF KNOWLEDGE BASE FOR CYBER SECURITY SYSTEMS ON THE BASIS OF SUBJECT IDENTIFICATION METHOD
Authors: Lakhno Valerii , Kasatkin Dmytro , Misiura Maksym , Husiev Borys
Published: June 2020

The article presents the results of research performed in the process of designing an expert system (ES) designed to assess the threats to information security (IS) of critical information facilities (CIF). The approach to designing of expert system on the basis of syllogisms and logic of predicates, and also a method of meaningful identification of objects of knowledge base (KB) is offered. The essence of the method is that each object of the database of the projected EU, is matched by a tuple of keywords (ToK), the significance of which is determined by experts. Thus, each database object is placed in accordance with the element of the finite fuzzy topological space of the database objects. Meaningful identification takes place on the distance between the objects of the database. The approach proposed in the work, in comparison with the decisions of other authors, has a number of advantages. Namely, it allows: to model different variants of cyber threat scenarios for CIF and their consequences; determine the contribution of each of the factors or components of the architecture of the IS CIF to the overall picture of the probability of a cyber threat to the CIF; model the interaction of all IS factors and, if necessary, visualize this interaction; calculate and further rank the values of cyber threat probabilities for CIF for specific threat scenarios; automate the processes of threat modeling through the use of developed software and significantly reduce the time for audit of threats. It is shown that the use of the method of meaningful identification allows to increase the adequacy of the models of the selected subject area, as well as to prevent erroneous introduction of the same judgments of experts and goals in the EU database, in particular by combining hierarchies of goals formed by different expert groups. It is shown that the method can also be used to find the goals of the hierarchy, the exact wording of which, according to keywords, is unknown.
ARCHITECTURE SECURITY PRINCIPLES OF THE ANDROID APPLICATIONS-BASED INFORMATION SYSTEM
Authors: Drahuntsov Roman , Rabchun Dmytro , Brzhevska Zoreslava
Published: June 2020

In this article common attack vectors on the information systems, which are based on the Android client applications, are observed, analyzed and compared. The purpose of this analysis consists in creating the theoretical base for development the practical principles of securing the architecture level of such systems. To accomplish the aims set, there was conducted the categorization of attacks and vulnerabilities specific to the Android information infrastructure and environment. There were also conducted analysis of Android application functional components and typical underlying infrastructure which have possible impact on a system security. Available data about the widespread vulnerabilities of the described elements was analyzed in context of possible exploitation. Based on the Android application usage model there were figured out several adversary models and attack vectors related to the researched information system type. Developed adversary models were formed with a focus on technical possibilities and threat abstraction. Mentioned vectors can be used by an attacker to violate the confidentiality and integrity of critical information in the system. The carried out research was used to form the characteristic comparison of the mentioned vectors and adversary models to evaluate the attack surface on the different parts of information system represented as attack vectors. As a result, we have developed the theoretical principles for securing the architecture of Android applications-driven information systems. Achieved results can be used to form the threat and adversary model, create practical recommendations for the information risk reducing practices in Android-applications driven information systems and to develop the technical requirements for security testing and development.
Subsampled Rényi Differential Privacy and Analytical Moments Accountant
Authors: Wang Yu-Xiang , Balle Borja , Kasiviswanathan Shiva
Published: June 2020

We study the problem of subsampling in differential privacy (DP), a question that is the centerpiece behind many successful differentially private machine learning algorithms. Specifically, we provide a tight upper bound on the Renyi Differential Privacy (RDP) [Mironov, 2017] parameters for algorithms that: (1) subsample the dataset, and then (2) apply a randomized mechanism M to the subsample, in terms of the RDP parameters of M and the subsampling probability parameter.Our results generalize the moments accounting technique, developed by [Abadi et al. 2016] for the Gaussian mechanism, to any subsampled RDP mechanism.
Tek Nokta Enjeksiyonlu Buji ile Ateşlemeli Bir Motorda Motor Devri ve Yükünün Motor Titreşimleri ve Gürültüye Etkisinin Deneysel İncelenmesi
Authors: TOPGÜL Tolga , SARIDEMİR Suat , ZAMAN Çağatay
Published: June 2020

Titreşim ve gürültü gerek günlük hayatta gerekse enerji üretim ve dönüşüm sistemlerinde istenmeyen etkilerdir. Bu çalışmada, motorun temel işletme parametrelerinden olan motor devri ve yükünün buji ile ateşlemeli bir motorda gürültü ve titreşime etkisi ele alınmıştır. Çalışma deneysel olarak iki aşamada gerçekleştirilmiştir. İlk olarak yüksüz motor şartlarında farklı motor devirlerinde deneyler yapılmıştır. İkinci aşamada sabit motor devrinde (1750 rpm) motor farklı yüklerde çalıştırılmıştır. Bu deney 2500 rpm motor devrinde de tekrarlanmıştır. Yapılan deneylerde elde edilen sonuçlar hem motor devrinin hem de motor yükünün titreşim ve gürültüyü arttırdığı görülmüştür.
Solidaridad y compromiso social en dermatología
Authors: Velásquez Margarita María
Published: June 2020

La solidaridad, entendida como la unión de diferentes voluntades para conseguir el bien común, es un valor de gran trascendencia, que permite superar situaciones críticas, resistir con firmeza la adversidad y asumir grandes desafíos (1). Es un factor de cambio que dignifica a los individuos y a la sociedad.
¿Reconoce esta clave diagnóstica? Parte 1
Authors: Ruiz Restrepo Juan David , Ospina Gómez Juan Pablo , Álvarez Alvarado Dellys Adriana , Gallo Echeverri Simón
Published: June 2020

Paciente de 74 años, ama de casa, residente de Bello, Antioquia, Colombia. Consultó por un cuadro clínico de lesión única en la mejilla derecha, de crecimiento lento y asintomática. Solamente ha usado antisolar como tratamiento. No tiene compromiso de otras zonas.
Psoriasis pustulosa anular: reporte de un caso y revisión de la literatura
Authors: Giraldo Melisa , Mosquera Elsa Stella , Seidel Ángela
Published: June 2020

La psoriasis pustulosa anular es una patología poco frecuente, variante de la psoriasis pustulosa generalizada, donde la respuesta a los tratamientos es más variable y cuya fisiopatología involucra la mutación de los genes IL-36RN y CARD14. En la actualidad, son pocos los casos clínicos reportados en la literatura científica.
Reportamos una paciente de 50 años con las características clínicas de esta enfermedad y su abordaje terapéutico. Se presenta una revisión de la literatura.
ANALISIS PENERAPAN AKUNTANSI PAJAK PENGHASILAN PASAL 23 PADA PERUSAHAAN JASA PERBANKAN
Authors: Hilendria Anggun , Lalu Takdir Jumaidy  , D. Tiallurra Della Nabila
Published: June 2020

This study aims to determine the application of income tax accounting article 23 in the business activities of Mataram BTN Bank. The results of the study explained that Mataram BTN Bank has approved the payment of income tax article 23 on vehicle rental in accordance with applicable tax regulations and has recorded accounting for vehicle rental costs and taxes on vehicle rental, calculates tax on vehicle rental, tax payment and tax reporting.
RELEVANSI NILAI AKUNTANSI AKRUAL VERSUS KAS
Authors: Fikri Muhammad Ali , Zuhrotul Isnaini  , Rahmi Sri Ramadhani
Published: June 2020

Value relevance specifically explains the relationship between the dependent variable, which is based on the price of a security, and the independent variable of accounting information. There are two common measurement methods used by investors to determine the value of accounting information, namely the profit and loss approach and the balance sheet approach which are both accrual-based. This study uses a qualitative approach, which employed respondents of lecturers of Capital Market subjects, Accountants/consultants, and members of the IAI of NTB Region. The results of the study generally states that the accrual approach has a small impact on changes in stock prices and different from the cash flow.
Avaliação da implementação da Política Nacional de Saúde Integral à população LGBT em um município da região Sudeste do Brasil
Authors: Guimarães Nilo Plantiko , Sotero Rafaela Lirio , Cola João Paulo , Antonio Suzana , Galavote Heletícia Scabelo
Published: June 2020

A população LGBT (Lésbicas, Gays, Bissexuais, Travestis e Transexuais), por não se encaixar nos padrões heteronormativos, recebe um tratamento pejorativo e excludente, o que limita o acesso aos serviços de saúde. Este estudo tem como objetivos avaliar a implementação da Política Nacional de Saúde Integral à População LGBT (PNAIPLGBT) na atenção básica de saúde e compreender o conhecimento de enfermeiros da Estratégia Saúde da Família acerca da diversidade sexual e da homofobia. Trata-se de um estudo descritivo, exploratório e de natureza qualitativa. Os participantes relatam ausência ou limitação de conhecimento sobre a PNAIPLGBT. Assim, a falta de conhecimento sobre o público LGBT e o despreparo dos profisionais de saúde para acolher o público em questão resultam na restrição do acesso da população LGBT aos serviços de saúde, o que afeta diretamente na realização da Política Nacional de Atenção Integral à População LGBT.
Diversidade e comunicação: percepções de surdos sobre atividade de educação em saúde realizada por estudantes de medicina
Authors: Yonemotu Bianca Pereira Rodrigues , Vieira Camila Mugnai
Published: June 2020

A comunidade surda possui cultura e linguagem próprias, desconhecidas pela maioria dos ouvintes, o que a exclui de vários processos da sociedade. As barreiras na comunicação e o preconceito difiultam seu acesso a serviços de saúde. Analisou-se a vivência de uma atividade prática de Educação em Saúde com 19 surdos feita por 20 estudantes do primeiro ano de um curso de medicina. Após um curso de Língua Brasileira de Sinais, os estudantes realizaram uma atividade junto aos surdos, na qual apresentaram palestras sobre temas de saúde e interagiram em ações como aferição da pressão e cálculo do Índice de Massa Corporal. Posteriormente, os surdos participaram de dois grupos focais para relatarem sua experiência. A análise dos dados deu-se pelo Discurso do Sujeito Coletivo. Os surdos fiaram satisfeitos com a interação, relataram preocupação com prevenção e autocuidado e expectativas positivas quanto à formação de médicos humanizados e qualifiados para seu atendimento.
A rede de desinformação e a saúde em risco: uma análise das fake news contidas em 'As 10 razões pelas quais você não deve vacinar seu filho'
Authors: Fernandes Carla Montuori , Montuori Christina
Published: June 2020

Este artigo tem por objetivo contrapor o conjunto de argumentos em que se apoiaram as fake news contidas em 'As 10 razões pelas quais você não deve vacinar seu fiho', divulgadas na página do Facebook Pensadores contra o sistema, com pesquisas científias publicadas na literatura da área de vacinação e imunização. Pretende-se, ainda, apresentar dados que apontam o decréscimo dos indicadores de vacinação no Brasil e no mundo, estabelecendo possível associação dessa diminuição com o avanço das notícias falsas que têm sido propagadas no ambiente virtual. Observou-se ao longo da pesquisa que a nova ambiência midiática propiciou a expansão de informações falsas sobre vacinação, apoiadas em dados que parecem se estruturar em argumentos científios, mas não resultam da aplicação de experimentações e de métodos seguros.
Medio Ambiente y Comunicación: una mirada de la producción científica en América Latina
Authors: Nepote Ana Claudia , Massarani Luisa , Rocha Mariana
Published: June 2020

Este artigo faz parte de um estudo mais amplo que visou mapear a produção acadêmica no campo da divulgação científia na América Latina, em particular artigos publicados em periódicos científios revisado por pares. A coleta do material foi realizada em um período de seis meses, entre março e setembro de 2016, mas se referiu a todos os artigos identifiados, portanto, desde a década de 1980. A busca foi realizada em revistas acadêmicas da América Latina e de outras regiões do mundo que publicam artigos na área. Neste trabalho, analisamos especifiamente os artigos relacionados à divulgação científia e meio ambiente. Os resultados mostram que a produção acadêmica na região tem pouco mais de 20 anos. A maioria dos artigos foi publicada em revistas brasileiras (62%). Grande parte (92%) da contribuição para pesquisa e conhecimento nesse campo vem do Brasil e México. Cerca de um terço dos artigos publicados referemse a museus e centros de ciências, destacando o papel educacional que esses espaços têm para questões ambientais. É discutida a importância de promover maior pesquisa colaborativa e que envolvam outras disciplinas sobre questões ambientais na região.
Measurement of Instantaneous Wave-free Ratio through a Diagnostic Catheter: Comparison of the Results between 4Fr and 5Fr
Authors: Masuda Shinichiro , Uemura Ryota , Saiki Yoshiyuki , Haraki Tatsuo , Lee Takeshi
Published: June 2020

Background

Clinical evidence of coronary pressure assessment through a diagnostic catheter is limited. The aim of this study was to assess the difference, safety, and rate of successful measurement of Instantaneous Wave-free Ratio (iFR) through 4Fr and 5Fr diagnostic catheters.

Methods

This single-centre prospective study included 32 lesions among 24 patients exhibiting intermediate coronary stenosis on coronary angiography. iFR measurements were performed through 4Fr and 5Fr diagnostic catheters for each lesion. The primary outcome was the reliability, as assessed by a Bland—Altman plot, for comparison of the mean differences [mean ± 2 Standard Deviations (SDs)], and the agreement on the Kappa coefficient, using a threshold iFR value of 0.89. The secondary outcome was the rate of successful iFR measurement. Safety was assessed by procedural complications and in-hospital Major Adverse Cardiac Events (MACE).

Results

The mean difference was −0.0003 ± 0.058, according to the Bland–Altman plot. One lesion was out of the range of 2 SDs. There was good agreement (Kappa coefficient = 0.85), and the correlation coefficient between the 4Fr and 5Fr catheters was 0.948 (p < 0.001). The success rate was not significantly different between the 4Fr and 5Fr catheters (90.6% vs. 96.9%, p = 0.09), although the 4Fr catheter had a lower success rate. No procedural complications or in-hospital MACE occurred.

Conclusion

Our findings suggest that iFR measurements could be safely performed, with similar reliability and success rate, through either the 4Fr or 5Fr diagnostic catheter.
Molecular Genetic Testing of Stability and Identification of Vnukovo-32 Strain Used for Production of the Cultural Concentrated Purified Inactivated Dry Rabies Vaccine
Authors: Ignatyev G. M. , Oksanich A. S. , Antonova L. P. , Samartseva T. G. , Mosolova S. V. , Mefed K. M. , Gmyl L. V. , Netesova N. A.
Published: June 2020

Rabies is an acute viral disease caused by a virus of the Rhabdoviridae family of the Lyssavirus genus, which affects the central nervous system and is characterised by absolute mortality. Vaccination is the only way to prevent the disease in humans. One of the products used for vaccination is a cultural concentrated purified inactivated dry rabies vaccine produced by the Federal State Budgetary Institution of Science “Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences” (hereinafter—Chumakov Center).

The aim of the study was to examine the structure of the working virus seed of Vnukovo-32 strain used by the Chumakov Center for rabies vaccine production, to assess its genetic stability during production, to explore the possibility of using molecular genetic methods for identification of the production strain in the finished dosage form, and to study the nucleotide sequence of the CVS strain.

Materials and methods: Vnukovo-32 rabies virus production strain, working virus seeds, finished batches of the rabies vaccine, CVS fixed rabies virus strain used in the assessment of specific immunity. The molecular genetic study was performed using RT-PCR followed by restriction and sequencing.

Results: the paper presents the results of nucleotide sequence analysis of the G gene fragment obtained from the Vnukovo-32 production strain, batches of the working virus seed, and finished batches of the rabies vaccine produced in 2012, 2018, and 2019, and the CVS fixed rabies virus strain used in the assessment of the vaccine’s specific immunity. The study demonstrated that restriction analysis could be used for Vnukovo-32 strain identification at all production stages, including the finished dosage form.

Conclusion: Vnukovo-32 and CVS strains used by the Chumakov Center are rabies viruses. Analysis of the nucleotide sequence of the G gene fragment showed that the Vnukovo-32 strain remains stable throughout different production stages. The obtained nucleotide sequence of gene G of the Vnukovo-32 strain was deposited in GenBank (accession number MN116503). The study demonstrated that restriction analysis could be used for Vnukovo-32 strain identification at all production stages, including the finished dosage form.
Prospects for Improving Quality Evaluation of the Live Brucellosis Vaccine in Terms of Specific Activity
Authors: Kasina I. V. , Alekseeva S. A. , Nemirovskaya T. I.
Published: June 2020

Prophylactic immunisation against brucellosis is part of the National Immunisation Schedule for Epidemic Settings. The immunisation is performed with a live vaccine—a lyophilized suspension of the Brucella abortus strain 19 BА in a stabilizing medium. The paper presents the results of quality evaluation of 9 batches of live brucellosis vaccine that were submitted to the Testing Centre for Evaluation of Medicinal Immunobiological Products’ Quality of the Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation for assessment of the product’s compliance with the established specifications. The paper also presents the results of evaluation of the passport information provided by the manufacturer for these batches. There is no doubt about the need for objective quality evaluation of brucellosis vaccines as well as about the significance of its improvement.

The aim of study was to assess the prospects for improving quality evaluation of live brucellosis vaccines in terms of Specific activity (concentration of microbial cells, number of living microbial cells, number of cutaneous doses).

Materials and methods: specific activity (concentration of microbial cells and number of living microbial cells) was determined by visual and microbiological methods using the industrial reference standard of brucellosis vaccine OSO 42-28-396-2018, batch 6 and the bacterial suspension of the Brucella abortus strain 19 BА acquired from the joint stock company Scientific and Production Association “Microgen” in 2016. The number of cutaneous doses in the brusellosis vaccine was determined by the calculation method. Statistical processing of the results was performed using Microsoft Excel.

Results: there was a mismatch between the brucella concentration coefficient of 1.7×109 microbial cells/mL determined by comparison with the industrial reference standard of bacterial suspension turbidity, 10 IU and the actual concentration of microbial cells obtained in the study. According to preliminary results, the brucella concentration coefficient corresponding to the industrial reference standard of bacterial suspension turbidity, 10 IU can reach 3.0×109 microbial cells/mL.

Conclusions: the obtained results can serve as a basis for amending the data on the brucella concentration coefficient in the Passport and the Instructions for use of the industrial reference standard of bacterial suspension turbidity, 10 IU, as well as the Specific activity section (concentration of microbial cells, number of living microbial cells, number of cutaneous doses) of the established specifications for the brucellosis vaccine. Before amending the information on the brucella concentration corresponding to 10 IU in the Passport and the Instructions for use of the reference standard of bacterial suspension turbidity (OSO 42-28-85P), additional studies should be performed with other types of brucella.
Bioethical Aspects of Improving the Production of Rabies Immunoglobulin in Russia
Authors: Generalov S. V. , Abramova E. G. , Gavrilova Yu. K.
Published: June 2020

The main objective of the present research was to review the studies that look into ways of improving production of anti-rabies immunoglobulin in terms of bioethical principles: ensuring patients’ right to receive quality pharmaceutical care, and compliance with the 3R principles. At the same time, compliance with bioethical principles should contribute to the improvement of production technology and the product quality, which is especially important for antirabies immunoglobulin due to the existing high demand for it. The paper analyses the current trends in avoidance of animal use in the production of rabies immunoglobulin. It summarises the main methods of production of serum products for post-exposure prophylaxis of rabies. The example of heterologous rabies immunoglobulin is used to substantiate the need to improve quality control of drugs by following the 3R principles. The paper highlights the potential use of cell cultures for determination of rabies immunoglobulin specific activity. The authors formulated the objectives that include development and use of pyrogen detection methods which do not involve animal use and are consistent with the current pharmacopoeial standards. They assessed the possibility and feasibility of removing Abnormal Toxicity Test for heterologous rabies immunoglobulin in accordance with the current international trends. The formulated objectives imply optimisation of production of heterologous rabies immunoglobulin in Russia in order to improve the quality of antirabies measures. The objectives include higher production volumes to ensure the availability of the product to patients, reduction of the product reactogenicity by using cell-culture technologies for obtaining rabies antigen, as well as development and implementation of in vitro test methods for product quality control in terms of Specific activity, Pyrogenicity, and Abnormal toxicity
Determinación del factor forma (FF): el caso del Área Metropolitana de Mendoza
Authors: Arboit Mariela E. , Maglione Dora S. , Mutani Guglielmina
Published: June 2020

El trabajo estudia el Factor de Forma (FF), en el Área Metropolitana de Mendoza (AMM) y sus seis jurisdicciones político-administrativas (denominadas departamentos), como parte de la problemática del desarrollo ambiental y energéticamente sostenible del sector edilicio en ciudades de la región árida del centro-oeste de Argentina.

Metodológicamente se calculó la superficie de envolvente y volumen para los edificios construidos en el área de estudio, en sistemas de información geográfica (SIG), que permitieron obtener resultados y analizar estadísticamente la variable FF (considerando para su cálculo una o dos superficies horizontales de pérdida), categorizada en función de una escala de valores en tres categorías. La evaluación indica, para todos los departamentos, predominancia de construcciones en la Categoría 2. Los resultados han permitido desarrollar información significativa disponible para estudios futuros de estrategias y prospectivas de carácter energético. Las conclusiones del estudio espacial evidencian que es posible elaborar estrategias energéticas, basadas en los edificios existentes, identificando construcciones con valores de FF superiores a 1.20 y departamentos que requieren una prioridad de intervención.
Urbanización de la pobreza en el aglomerado Gran Salta (Noroeste Argentino). Sus manifestaciones actuales
Authors: Del Castillo Alejandra Carolina
Published: June 2020

El presente trabajo se propone analizar la urbanización de la pobreza en el aglomerado Gran Salta y sus manifestaciones actuales desde una perspectiva histórica. Los interrogantes que orientan su desarrollo son: ¿cuáles son los principales procesos que incidieron en la urbanización de la pobreza en el aglomerado Gran Salta?; ¿cómo se manifestó espacialmente dicho proceso?; ¿qué magnitud adquiere la pobreza en los inicios del siglo XXI?; ¿cuáles son las características sociodemográficas de la población que reside en las áreas de mayor pobreza?

Los resultados evidencian que la urbanización de la pobreza tiene más de un siglo de desarrollo, pero desde la década de 1960 adquiere un desarrollo disruptivo. En la periferia de la ciudad se multiplican villas de emergencia y barrios de loteos económicos precarios. En los inicios del siglo XXI se observa un crecimiento sostenido de la pobreza, con el crecimiento de numerosos asentamientos informales, y un proceso de acumulación de desventajas para las poblaciones afectadas.
De “Barracas al fondo” al barrio auténtico: un análisis de dos casos de patrimonialización al sur de la ciudad de Buenos Aires, Argentina
Authors: Hernández Silvia
Published: June 2020

Este artículo analiza la patrimonialización de un sector al oeste del barrio sureño de Barracas (Buenos Aires, Argentina), alejado de las zonas más comerciales y céntricas, a partir de dos casos geográficamente próximos: el Pasaje Lanín y el café y bodegón La Flor de Barracas. El propósito es mostrar cómo los actores implicados en estos dos casos traducen mediante estrategias heterogéneas aspectos del pasado y del presente barriales al discurso del patrimonio, en el cual la autenticidad y la identidad locales aparecen como valores centrales. El cambio de imagen del área a través del patrimonio se articula con una recualificación urbana más amplia. Se analizan entrevistas, material hemerográfico, sitios de internet y redes sociales de los actores implicados y otros documentos relevantes, producidos desde 1998.