bluuebunny/crossref_metadata_2025 huggingface dataset:
Gait Pathology in Subjects with Patellofemoral Instability: A Systematic Review
Authors: Habersack Andreas , Kraus Tanja , Kruse Annika , Regvar Katharina , Maier Michael , Svehlik Martin
Published: August 2022

Identifying potential gait deviations in patellofemoral instability (PI) can help with the development of effective rehabilitation strategies. The purpose of this systematic review was to examine whether there are specific gait alterations in subjects with PI. The present review followed the PRISMA guidelines and was initially registered at PROSPERO (CRD42021236765). The literature search was carried out in the databases of PubMed, the Cochrane library, Web of Science, ClinicalTrials.gov, and Medline. The search strategy resulted in the identification of seven relevant publications. Subjects with PI show decreased walking speed, stride length, and cadence. Some studies reported changes not only in knee kinematics and kinetics but also in hip and ankle kinematics and kinetics. There is evidence that most subjects with PI walk with a quadriceps avoidance gait and show increased genu valgum posture, but there is still great variability in the coping responses within individuals with PI. The discrepancy among the study results might underpin the fact that PI is a multifactorial problem, and subjects cope with the different underlying morphological as well as functional deficits using a variety of gait strategies, which makes the interpretation and understanding of the gait of subjects with PI a clinically challenging task.
Acute Effects of Facial Coverings on Anaerobic Exercise Performance in College-Aged Adults
Authors: Conners Ryan T. , Whitehead Paul N. , Skarp Thomas , Waller Briana , Richard Mark , Bain Carrington , Monks Megan , Faghy Mark A.
Published: August 2022

The use of facial coverings has been amplified during the COVID-19 pandemic as a means to minimize the spread of disease. However, facial coverings may impede ventilation during high-intensity activity, leading to a reduction in cardiopulmonary exercise capacity. Thus, the purpose of this study was to determine the acute impact of different facial coverings on exercise performance in college-aged individuals during a 300-yard shuttle. It was hypothesized that the lowest heart rate (HR), completion time (CT), and rate of perceived exertion (RPE) would occur with no mask. Furthermore, it was hypothesized the SHEMA97 mask would have lower HR, CT, and RPE compared to surgical and fabric masks. Results showed the use of the fabric mask resulted in significantly higher HR compared to no mask (p = 0.006). The SHEMA97 mask resulted in faster CT and lower RPE compared to both the fabric and surgical masks (p < 0.001). All mask conditions yielded significantly higher levels of perceived discomfort than wearing no mask (p < 0.05). While the use of facial coverings can help prevent the spread of disease, their use during exercise may pose limitations to performance; however, the ability of the SHEMA97 to provide minimal changes to CT and RPE provides a promising option.
Heavy Metals in River Sediments: Contamination, Toxicity, and Source Identification—A Case Study from Poland
Authors: Sojka Mariusz , Jaskuła Joanna
Published: August 2022

This study investigated the spatial distribution, contamination, potential ecological risks and quantities of pollutant sources of six heavy metals (HMs) in sediments of 47 rivers. The catchments of the investigated rivers are situated in Poland, but some of them are located in Slovakia, the Czech Republic, and Germany. Cluster analysis was applied to analyze the spatial distribution of Cd, Cr, Cu, Ni, Pb, and Zn in river sediments. Moran I and Getis-Ord Gi* statistics were calculated to reveal the distribution pattern and hotspot values. Principal component analysis (PCA) and positive matrix factorization (PMF) were used to identify pollution sources. Furthermore, geochemical indices and sediment quality guidelines allowed us to assess sediment contamination and potential toxic effects on aquatic biota. The results showed that in 1/3rd of the rivers, the HM pattern and concentrations indicate sediment contamination. The EF, PLI, and MPI indices indicate that concentrations were at a rather low level in 2/3rd of the analyzed rivers. Only in individual rivers may the HMs have toxic effects on aquatic biota. Spatial autocorrelation analysis using the Moran I statistic revealed a random and dispersed pattern of HMs in river sediments. PCA analysis identified two sources of HMs’ delivery to the aquatic environment. Cr, Cu, Ni, Pb, and Zn originate from point and non-point sources, while Cd concentrations have a dominant natural origin. The PMF identified three sources of pollution. Among them, urban pollution sources are responsible for Cu delivery, agricultural pollution for Zn, and industrial pollution for Ni and Cr. Moreover, the analysis showed no relationship between catchment land-use patterns and HM content in river sediments.
Family Perspectives Related to Caring for Mental Health Care Users: A Case Study in the Long-Term Mental Health Institutions of Limpopo Province, South Africa
Authors: Mabunda Nkhensani F. , Mangena-Netshikweta Mutshinyalo L. , Lebese Rachel T. , Olaniyi Foluke C.
Published: August 2022

Family involvement in long-term mental health care is a significant therapeutic aspect in managing mentally ill patients. This study aimed to determine the perspectives of family members about caring for mental health care users at selected long-term mental health institutions in Limpopo Province. A qualitative explorative and contextual descriptive design was used. Purposive sampling was used to select family members with mental health care users admitted in long-term health institutions in Limpopo Province. Data were collected with in-depth individual interviews aided by an audio recorder and field notes. Data were qualitatively analysed. Trustworthiness and ethical considerations were ensured. Two themes yielded from the interviews: Perspectives of family members about their involvement in the care of mental health care users and difficulties in caring for mental health care users at home when granted leave of absence or discharged. Sub-themes: Caring for mental health care users leads to an understanding of mental illness; Lack of skill and inability to monitor mental health care users at home; Mental health care users abuse substances during leave of absence which makes family reluctant to request them for visit; Caring for mental health care users at home viewed as a difficult task and stigma from the community. The challenges experienced by family members contribute to poor interaction with mentally ill patients. We recommend that family members of mental health care users be educated about mental illnesses and encouraged to participate in the care of the patients.
Connexins Signatures of the Neurovascular Unit and Their Physio-Pathological Functions
Authors: Vicario Nunzio , Parenti Rosalba
Published: August 2022

Central nervous system (CNS) homeostasis is closely linked to the delicate balance of the microenvironment in which different cellular components of the neurovascular unit (NVU) coexist. Intercellular communication plays a pivotal role in exchanges of signaling molecules and mediators essential for survival functions, as well as in the removal of disturbing elements that can lead to related pathologies. The specific signatures of connexins (Cxs), proteins which form either gap junctions (GJs) or hemichannels (HCs), represent the biological substrate of the pathophysiological balance. Connexin 43 (Cx43) is undoubtedly one of the most important factors in glia–neuro–vascular crosstalk. Herein, Cxs signatures of every NVU component are highlighted and their critical influence on functional processes in healthy and pathological conditions of nervous microenvironment is reviewed.
Genetic Insight into Disease Resistance Gene Clusters by Using Sequencing-Based Fine Mapping in Sunflower (Helianthus annuus L.)
Authors: Ma Guojia , Song Qijian , Li Xuehui , Qi Lili
Published: August 2022

Rust and downy mildew (DM) are two important sunflower diseases that lead to significant yield losses globally. The use of resistant hybrids to control rust and DM in sunflower has a long history. The rust resistance genes, R13a and R16, were previously mapped to a 3.4 Mb region at the lower end of sunflower chromosome 13, while the DM resistance gene, Pl33, was previously mapped to a 4.2 Mb region located at the upper end of chromosome 4. High-resolution fine mapping was conducted using whole genome sequencing of HA-R6 (R13a) and TX16R (R16 and Pl33) and large segregated populations. R13a and R16 were fine mapped to a 0.48 cM region in chromosome 13 corresponding to a 790 kb physical interval on the XRQr1.0 genome assembly. Four disease defense-related genes with nucleotide-binding leucine-rich repeat (NLR) motifs were found in this region from XRQr1.0 gene annotation as candidate genes for R13a and R16. Pl33 was fine mapped to a 0.04 cM region in chromosome 4 corresponding to a 63 kb physical interval. One NLR gene, HanXRQChr04g0095641, was predicted as the candidate gene for Pl33. The diagnostic SNP markers developed for each gene in the current study will facilitate marker-assisted selections of resistance genes in sunflower breeding programs.
C10Pred: A First Machine Learning Based Tool to Predict C10 Family Cysteine Peptidases Using Sequence-Derived Features
Authors: Malik Adeel , Mahajan Nitin , Dar Tanveer Ali , Kim Chang-Bae
Published: August 2022

Streptococcus pyogenes, or group A Streptococcus (GAS), a gram-positive bacterium, is implicated in a wide range of clinical manifestations and life-threatening diseases. One of the key virulence factors of GAS is streptopain, a C10 family cysteine peptidase. Since its discovery, various homologs of streptopain have been reported from other bacterial species. With the increased affordability of sequencing, a significant increase in the number of potential C10 family-like sequences in the public databases is anticipated, posing a challenge in classifying such sequences. Sequence-similarity-based tools are the methods of choice to identify such streptopain-like sequences. However, these methods depend on some level of sequence similarity between the existing C10 family and the target sequences. Therefore, in this work, we propose a novel predictor, C10Pred, for the prediction of C10 peptidases using sequence-derived optimal features. C10Pred is a support vector machine (SVM) based model which is efficient in predicting C10 enzymes with an overall accuracy of 92.7% and Matthews’ correlation coefficient (MCC) value of 0.855 when tested on an independent dataset. We anticipate that C10Pred will serve as a handy tool to classify novel streptopain-like proteins belonging to the C10 family and offer essential information.
The Neurobiological Links between Stress and Traumatic Brain Injury: A Review of Research to Date
Authors: Zheng Lexin , Pang Qiuyu , Xu Heng , Guo Hanmu , Liu Rong , Wang Tao
Published: August 2022

Neurological dysfunctions commonly occur after mild or moderate traumatic brain injury (TBI). Although most TBI patients recover from such a dysfunction in a short period of time, some present with persistent neurological deficits. Stress is a potential factor that is involved in recovery from neurological dysfunction after TBI. However, there has been limited research on the effects and mechanisms of stress on neurological dysfunctions due to TBI. In this review, we first investigate the effects of TBI and stress on neurological dysfunctions and different brain regions, such as the prefrontal cortex, hippocampus, amygdala, and hypothalamus. We then explore the neurobiological links and mechanisms between stress and TBI. Finally, we summarize the findings related to stress biomarkers and probe the possible diagnostic and therapeutic significance of stress combined with mild or moderate TBI.
Circulating miR-200 Family and CTCs in Metastatic Breast Cancer before, during, and after a New Line of Systemic Treatment
Authors: Fischer Chiara , Turchinovich Andrey , Feisst Manuel , Riedel Fabian , Haßdenteufel Kathrin , Scharli Philipp , Hartkopf Andreas D. , Brucker Sara Y. , Michel Laura , Burwinkel Barbara , Schneeweiss Andreas , Wallwiener Markus , Deutsch Thomas M.
Published: August 2022

The extracellular circulating microRNA (miR)-200 regulates epithelial-mesenchymal transition and, thus, plays an essential role in the metastatic cascade and has shown itself to be a promising prognostic and predictive biomarker in metastatic breast cancer (MBC). Expression levels of the plasma miR-200 family were analyzed in relationship to systemic treatment, circulating tumor cells (CTC) count, progression-free survival (PFS), and overall survival (OS). Expression of miR-200a, miR-200b, miR-200c, miR-141, and miR-429, and CTC status (CTC-positive ≥ 5 CTC/7.5 mL) was assessed in 47 patients at baseline (BL), after the first completed cycle of a new line of systemic therapy (1C), and upon the progression of disease (PD). MiR-200a, miR-200b, and miR-141 expression was reduced at 1C compared to BL. Upon PD, all miR-200s were upregulated compared to 1C. At all timepoints, the levels of miR-200s were elevated in CTC-positive versus CTC-negative patients. Further, heightened miR-200s expression and positive CTC status were associated with poorer OS at BL and 1C. In MBC patients, circulating miR-200 family members decreased after one cycle of a new line of systemic therapy, were elevated during PD, and were indicative of CTC status. Notably, increased levels of miR-200s and elevated CTC count correlated with poorer OS and PFS. As such, both are promising biomarkers for optimizing the clinical management of MBC.
Classical and Non-Classical HLA Alleles as Supplementary Markers in Indirect Kinship Parentage Testing
Authors: Kouniaki Diamanto , Tsirogianni Alexandra
Published: August 2022

A civil paternity investigation involving the parents of the deceased alleged father in order to establish a family relationship is presented. On the basis of the 23 autosomal short tandem repeat (aSTR) genotyping results, conclusive proof of paternity was not achieved, as the probability of paternity (W) was calculated to 0.99988. Additional genetic data of 17 classical and non-classical human leukocyte alleles (HLA) typing by next-generation sequencing (NGS) at a high-resolution level supported the hypothesis of grandpaternity over the hypothesis of coincidental paternal obligate allele (POA) sharing (total WaSTR&HLA = 0.9999998). The present study demonstrates the utility of 17 HLA genetic markers-typing in the solution of deficiency cases of disputed parentage.
A New Deep Learning Algorithm with Activation Mapping for Diabetic Retinopathy: Backtesting after 10 Years of Tele-Ophthalmology
Authors: Pareja-Ríos Alicia , Ceruso Sabato , Romero-Aroca Pedro , Bonaque-González Sergio
Published: August 2022

We report the development of a deep learning algorithm (AI) to detect signs of diabetic retinopathy (DR) from fundus images. For this, we use a ResNet-50 neural network with a double resolution, the addition of Squeeze–Excitation blocks, pre-trained in ImageNet, and trained for 50 epochs using the Adam optimizer. The AI-based algorithm not only classifies an image as pathological or not but also detects and highlights those signs that allow DR to be identified. For development, we have used a database of about half a million images classified in a real clinical environment by family doctors (FDs), ophthalmologists, or both. The AI was able to detect more than 95% of cases worse than mild DR and had 70% fewer misclassifications of healthy cases than FDs. In addition, the AI was able to detect DR signs in 1258 patients before they were detected by FDs, representing 7.9% of the total number of DR patients detected by the FDs. These results suggest that AI is at least comparable to the evaluation of FDs. We suggest that it may be useful to use signaling tools such as an aid to diagnosis rather than an AI as a stand-alone tool.
Migraine Prevention through Ketogenic Diet: More than Body Mass Composition Changes
Authors: Valente Mariarosaria , Garbo Riccardo , Filippi Francesca , Antonutti Alice , Ceccarini Veronica , Tereshko Yan , Di Lorenzo Cherubino , Gigli Gian Luigi
Published: August 2022

The ketogenic diet (KD) is gaining attention as a preventive treatment for migraine, which is sustained by many pre-clinical and clinical data. KD is also used for weight loss, and there is a relation between migraine and weight excess, but it is speculated that KD efficacy on migraine may go beyond this effect. We conducted a retrospective observational study on 23 migraine patients who received a KD and were evaluated at the baseline and then after 3 months both from a neurological and a nutritional point of view, including body mass composition analysis. We observed a reduction in monthly headache days (12.5 ± 9.5 vs. 6.7 ± 8.6; p < 0.001) and in days of acute medication intake (11.06 ± 9.37 vs. 4.93 ± 7.99; p = 0.008). We also observed a reduction in patients’ weight (73.8 ± 15.2 vs. 68.4 ± 14.6; p < 0.001) and BMI (26.9 ± 6.2 vs. 23.7 ± 8.1; p < 0.001) with a decrement of the fat mass (28.6 ± 12.5 vs. 20.6 ± 9.8; p < 0.001). Patients who responded to KD and those who did not had no differences with respect to weight or fat mass loss. These data corroborate the utilization of KD as a preventive treatment for migraine and suggest that the efficacy of such an intervention is not only due to weight or fat mass loss but probably relies on other mechanisms specific to KD.
Recent Developments and Current Challenges of Heparin-Grafted Hemodialysis Membranes
Authors: Abdelrasoul Amira , Kalugin Denis , Shoker Ahmed
Published: August 2022

Hemodialysis (HD) is a life-sustaining extracorporeal blood purifying treatment for end-stage renal disease (ESRD) patients. However, this membrane-based therapy is associated with acute side effects, life-threatening chronic conditions, and unacceptably high morbidity and mortality rates. Numerous surface coatings have been developed to improve the blood compatibility of biomaterials. Heparin is a widely used anticoagulant substance that increases the clotting time and increases the membrane hemocompatibility in terms of platelet adhesion and protein adsorption and anti-clotting activity. However, using heparin is challenging due to its severe or life-threatening side effects such as heparin-induced thrombocytopenia (HIT), in addition to heparin induced thrombocytopenia and thrombosis (HITT). In addition, heparin is strongly electronegative and exhibits a binding affinity for the positive active sites of human serum proteins, which is an additional challenge. Consequently, covalently immobilized heparin would create a more charged surface to induce more blood–membrane interactions, and consequently more adsorbed human serum proteins and biochemical pathway activations, which can negatively affect dialysis patients. Therefore, the current critical review has thoroughly focused on different heparin HD membrane systems, the challenges of heparin-coated dialysis membranes, and the factors affecting its hemocompatibility, in addition to the methods that can be used to enhance its hemocompatibility. Furthermore, this review summarizes the advantages and disadvantages of heparin-grafted methods. Furthermore, the influence of the heparin-immobilization method on the hemocompatibility and performance of the HD membrane was comprehensively analyzed. Finally, we conclude with the future perspectives for the strategies toward the heparinization and heparin-like/mimicking modification of membrane surfaces.
Development of Improved Flexural and Impact Performance of Kevlar/Carbon/Glass Fibers Reinforced Polymer Hybrid Composites
Authors: Rout Sonali , Nayak Ramesh Kumar , Patnaik Suresh Chandra , Yazdani Nezhad Hamed
Published: August 2022

The present investigation focuses on developing cost-effective Carbon/Glass/Kevlar fiber-reinforced polymer hybrid composite laminates for achieving its synergistic effect on flexural and impact performance. It investigates the effect of stacking sequence induced by the use of different fiber types (Kevlar = K, glass = G, and carbon = C) on the flexural and impact performance of the composites. Five hybrid composites (labelled as A = [G2K3G2], B = [KG2CG2K], C = [CKGCGKC], D = [CGKCKGC], E = [CK2CK2C]) and three plain (i.e., non-hybrid) composites (F = [K]7, G = [G]7, H = [C]7) have been fabricated through manual pre-preg lay-up manufacturing techniques. The flexural strength and modulus, hardness, and Izod impact strength have been evaluated for the fabricated composites and compared. The results showed that the D-type hybrid composite achieves the maximum positive hybrid effect as compared to other hybrid composites, possesses a hardness of 59 BHN, a flexural strength of 380 MPa, and modulus of 36 GPa, and impact strength of 80 KJ/m2. The fracture surfaces of the hybrid composite specimen have been analysed using scanning electron microscopy, and compared against the properties achieved for enabling correlations. Furthermore, the cost-efficiency of the hybridization in terms of flexural strength/cost, modulus/cost, and impact strength/cost ratio were evaluated for potential engineering and design applications.
Primary Composition and Pigments of 11 Red Seaweed Species from the Center of Portugal
Authors: Freitas Marta V. , Inácio Leonardo G. , Martins Mendelson , Afonso Clélia , Pereira Leonel , Mouga Teresa
Published: August 2022

Macroalgae have been regarded as a natural food source since ancient times, their nutritional value being not only proven by recent studies, but also triggering further in-depth research efforts on the matter. The present study aims to provide an insight into the nutritional potential of selected red seaweed species collected in central Portugal by specifically comparing the moist yield and ash content, crude protein, total lipids, carbohydrates and pigment content between species and, ultimately, finding out if there are differences between taxa. The results obtained highlighted the most nutritionally appealing species, namely, Plocamium cartilagineum with respect to protein content (23.18% dw) and Sphaerocococcus coronopifolius with respect to carbohydrate content (40.23% dw), while none of the species studied showed a lipid content higher than 1.80% dw. Regarding pigment content, the highest concentrations of phycoerythrin, carotenoid and chlorophyll a were obtained, respectively, from P. cartilagineum (0.09 mg.mL−1), Porphyra umbilicalis (1.88 µg.g−1 fw) and Jania rubens (38.41 µg.mL−1). We concluded that there are significant differences between the species studied regarding their nutritional profile, with a marked difference between Corallinales and all other species not belonging to this order; regarding pigment content, this variation between orders was not observed. Nevertheless, all the studied species may act as promising complements in a human healthy diet.
Characterisation of Pythium aristosporum Oomycete—A Novel Pathogen Causing Rice Seedling Blight in China
Authors: Liu Jinxin , Zhang Ruisi , Xu Chuzhen , Liu Chunlai , Zheng Yanyan , Zhang Xue , Liu Shasha , Li Yonggang
Published: August 2022

Rice seedling blight is a globally occurring seedling disease caused by multiple pathogens. It is currently the most common disease affecting rice production in northeast China; hence, determining the causal agents, including its biological characteristics, host range, and fungicide efficacy is vital for its effective management. The present study obtained 45 pathogenic isolates from diseased rice seedlings in Suihua, Heilongjiang Province, China. Of these, five pathogens were identified based on their morphology and molecular identification, while 10 oomycete isolates were identified as Pythium aristosporum—the first to be reported in rice seedling blight. Its optimum growth conditions include a temperature of 25 °C, pH 6, and photoperiod of 24 h. Except for soybean (Glycine max (L.) Merr.), black soybean (Glycine max var.), and cucumber (Cucumis sativus L.), P. aristosporum can potentially infect and cause seedling blight on other hosts, such as wheat (Triticum aestivum L.), maize (Zea mays L.), sorghum (Sorghum bicolor (L.) Moench), alfalfa (Medicago sativa L.), oats (Avena sativa L.), and white clover (Trifolium repens L.). Its isolates were found to be highly sensitive to metalaxyl + propamocarb (EC50 = 0.0138 μg/mL) with 84.1% efficacy at 313 μg/mL. These results can serve as the basis for controlling P. aristosporum.
Consultation and Displacement in Large-Scale Agriculture Investment: Evidence from Oromia Region’s Shashamane Rural District
Authors: Alemu Yideg , Tolossa Degefa
Published: August 2022

The Shashamane rural district was selected as a target area and corridor of large-scale agriculture investment (LSAI) to produce surplus agricultural products and ensure local development by the state and private (domestic and foreign) investors. Shalo–Melega private LSAI projects started operation in 2008 in the Shashamane rural district. This farm project comprises a crop production site, construction of a road, a crop storage facility, and developing irrigation in a total of about 24,710.51 acres of land along the central Rift Valley basin, for long-term leases. Little attention has been paid to how land ownership has changed and transaction transparency; how the community has been consulted; whether free, prior, and informed consent (FPIC) has been provided; and how local people have been displaced. This study sought to investigate the consultation process, land transaction transparency, the use of FPIC, and local community dis-placement as a result of LSAI in the Shashamane rural district. The study adopted multi-method qualitative and quantitative data collection tools including primary data, collected from a directly impacted population of 134 households, using systematic random sampling techniques; key and in-depth informant interviews; focus group discussions (FGD); and field visits. Through the use of qualitative and qualitative research paradigms, a systematic analysis was conducted. The result of the study shows that 86.6% of respondents (both interested and affected) expressed that both government and the proponents were not taking in account their concerns during the consultation processes. Lack of free, prior, and informed consent (FPIC) reduces local people’s sense of recognition and status. Moreover, LSAI displaced the rural people from their area of settlement and farmland, triggered a shortage of communal grazing and forest resources. Additionally, nonequivalent and unsatisfactory mitigation and compensation methods highly triggers the negative impacts. As a result of manipulation and therapy used during the consultation process, we assert that the local community had less decision-making authority and that the risk to the farm was thereby increased. The government, investors, and local communities are three actors whose respective roles need to be strengthened and transparent. It is crucial to strengthen the implementation of customary land tenure rights to benefit local and indigenous people and civil society organizations (CSOs).
Two-Dimensional Heterostructure of PPy/CNT–E. coli for High-Performance Supercapacitor Electrodes
Authors: Lee Kwang Se , Kim Jung Yong , Park Jongwook , Ko Jang Myoun , Mugobera Sharon
Published: August 2022

The nano-biocomposite electrodes composed of carbon nanotube (CNT), polypyrrole (PPy), and E. coli-bacteria were investigated for electrochemical supercapacitors. For this purpose, PPy/CNT–E. coli was successfully synthesized through oxidative polymerization. The PPy/CNT–E. coli electrode exhibited a high specific capacitance of 173 F∙g−1 at the current density of 0.2 A∙g−1, which is much higher than that (37 F∙g−1) of CNT. Furthermore, it displayed sufficient stability after 1000 charge/discharge cycles. The CNT, PPy/CNT, and PPy/CNT–E. coli composites were characterized by x-ray diffraction, scanning electron microscopy, and surface analyzer (Brunauer–Emmett–Teller, BET). In particular, the pyrrole monomers were easily adsorbed and polymerized on the surface of CNT materials, as well as E. coli bacteria enhanced the surface area and porous structure of the PPy/CNT–E. coli composite electrode resulting in high performance of devices.
Finite Element Analysis of Elastoplastic Elements in the Iwan Model of Bolted Joints
Authors: Wang Sheng-Ao , Zhu Min , Xie Xin , Li Biao , Liang Tian-Xi , Shao Zhao-Qun , Liu Yi-Long
Published: August 2022

The Iwan model is composed of elastoplastic elements and is widely used to represent the stiffness degradation of bolted joints under mixed-mode loading (normal and tangential loading). The latest static methods of parameter identification established the relationship between the elastoplastic elements and the contact pressure under normal loading. Under mixed-mode loading, the parameters of the Iwan model are dynamic for the evolution of contact conditions. Therefore, static parameter identification methods are not suitable for the dynamic Iwan model. A new technique was proposed to identify the parameters of the elastoplastic elements in this paper. Firstly, several different finite element models were established. The influence of the contact method and the thread structure were analyzed, and a reliable and efficient bolted-joint modeling method was proposed. Secondly, the evolution of contact conditions was studied. The dynamic elliptical contact model and the ellipticity discrete method were proposed. Finally, the residual stiffness of the Iwan model was analyzed to establish the mapping between the residual stiffness and the bending of the screw. The results can provide a technique for identifying the parameters of the dynamic Iwan model.
A Hybrid Stochastic Deterministic Algorithm for Solving Unconstrained Optimization Problems
Authors: Alshamrani Ahmad M. , Alrasheedi Adel Fahad , Alnowibet Khalid Abdulaziz , Mahdi Salem , Mohamed Ali Wagdy
Published: August 2022

In this paper, a new deterministic method is proposed. This method depends on presenting (suggesting) some modifications to existing parameters of some conjugate gradient methods. The parameters of our suggested method contain a mix of deterministic and stochastic parameters. The proposed method is added to a line search algorithm to make it a globally convergent method. The convergence analysis of the method is established. The gradient vector is estimated by a finite difference approximation approach, and a new step-size h of this approach is generated randomly. In addition, a set of stochastic parameter formulas is constructed from which some solutions are generated randomly for an unconstrained problem. This stochastic technique is hybridized with the new deterministic method to obtain a new hybrid algorithm that finds an approximate solution for the global minimization problem. The performance of the suggested hybrid algorithm is tested in two sets of benchmark optimization test problems containing convex and non-convex functions. Comprehensive comparisons versus four other hybrid algorithms are listed in this study. The performance profiles are utilized to evaluate and compare the performance of the five hybrid algorithms. The numerical results show that our proposed hybrid algorithm is promising and competitive for finding the global optimum point. The comparison results between the performance of our suggested hybrid algorithm and the other four hybrid algorithms indicate that the proposed algorithm is competitive with, and in all cases superior to, the four algorithms in terms of the efficiency, reliability, and effectiveness for finding the global minimizers of non-convex functions.
A Hybrid Encryption Scheme for Quantum Secure Video Conferencing Combined with Blockchain
Authors: Zhu Dexin , Zheng Jun , Zhou Hu , Wu Jianan , Li Nianfeng , Song Lijun
Published: August 2022

Traditional video conference systems depend largely on computational complexity to ensure system security, but with the development of high-performance computers, the existing encryption system will be seriously threatened. To solve this problem, a hybrid encryption scheme for quantum secure video conferencing combined with blockchain is proposed in this study. In the system solution architecture, first, the quantum key distribution network is embedded in the classic network; then, the “classical + quantum” hybrid encryption scheme is designed according to the secret level required for the video conference content. Besides, the real-time monitoring module of the quantum key distribution network is designed to ensure that users can check the running state of the network at any time. Meeting minutes can be shared by combining with blockchain. In order to quickly query meeting minutes, a cache-efficient query method based on B+ tree is proposed. The experimental results show that compared with the traditional video conference system, the quantum secure video conference system sufficiently integrates the technical advantages of the quantum key distribution to resist the security threats such as channel eavesdropping and high-performance computational attacks while ensuring the stable operation of the classic system, thus providing a video conference system with a higher security level. Meanwhile, the query time cost of blockchain with different lengths is tested, and the query efficiency of the proposed method is 3.15-times higher than the original query efficiency of blockchain.
Analysis of Stochastic State-Dependent Arrivals in a Queueing-Inventory System with Multiple Server Vacation and Retrial Facility
Authors: Nithya M. , Joshi Gyanendra Prasad , Sugapriya C. , Selvakumar S. , Anbazhagan N. , Yang Eunmok , Doo Ill Chul
Published: August 2022

This article analyses a four-dimensional stochastic queueing-inventory system with multiple server vacations and a state-dependent arrival process. The server can start multiple vacations at a random time only when there is no customer in the waiting hall and the inventory level is zero. The arrival flow of customers in the system is state-dependent. Whenever the arriving customer finds that the waiting hall is full, they enter into the infinite orbit and they retry to enter the waiting hall. If there is at least one space in the waiting hall, the orbital customer enters the waiting hall. When the server is on vacation, the primary (retrial) customer enters the system with a rate of λ1(θ1). If the server is not on vacation, the primary (retrial) arrival occurs with a rate of λ2(θ2). Each arrival rate follows an independent Poisson distribution. The service is provided to customers one by one in a positive time with the rate of μ, which follows exponential distribution. When the inventory level drops to a fixed s, reorder of Q items is triggered immediately under (s,Q) ordering policy. The stability of the system has been analysed, and using the Neuts matrix geometric approach, the stationary probability vectors have been obtained. Moreover, various system performance measures are derived. The expected total cost analysis explores and verifies the characteristics of the assumed parameters of this model. The average waiting time of a customer in the waiting hall and orbit are investigated using all the parameters. The monotonicity of the parameters is verified with its characteristics by the numerical simulation. The discussion about the fraction time server being on vacation suggests that as the server’s vacation duration reduces, its fraction time also reduces. The mean number of customers in the waiting hall and orbit is reduced whenever the average service time per customer and average replenishment time are reduced.
Using Machine Learning in the Prediction of the Influence of Atmospheric Parameters on Health
Authors: Ranđelović Dragan , Ranđelović Milan , Čabarkapa Milan
Published: August 2022

Technological development has brought humanity to the era of an information society in which information is the main driver. This implies existing large amounts of data from which knowledge should be extracted. In this sense, artificial intelligence represents a trend applied in many areas of human activity. This paper is focused on ensemble modeling based on the use of several machine learning algorithms, which enable the prediction of the risk to human health due to the state of atmospheric factors. The model uses two multi-agents as a technique of emergent intelligence to make a collective decision. The first agent makes a partial decision on the prediction task by learning from the available historical data. In contrast, the second agent does the same from the data available in real-time. The proposed prediction model was evaluated in a case study related to the city of Niš, Republic of Serbia, and showed a better result than each algorithm separately. It represents a reasonable basis for further upgrading both in the scope of different groups of the atmospheric parameters and in the methodological sense, as well as technically through implementation in a practical web citizen service.
Ion Mobility-Derived Collision Cross-Sections Add Extra Capability in Distinguishing Isomers and Compounds with Similar Retention Times: The Case of Aphidicolanes
Authors: Xia Jinmei , Xiao Wenhai , Lin Xihuang , Zhou Yiduo , Qiu Peng , Si Hongkun , Wu Xiaorong , Niu Siwen , Luo Zhuhua , Yang Xianwen
Published: August 2022

The hyphenation of ion mobility spectrometry with high-resolution mass spectrometry has been widely used in the characterization of various metabolites. Nevertheless, such a powerful tool remains largely unexplored in natural products research, possibly mainly due to the lack of available compounds. To evaluate the ability of collision cross-sections (CCSs) in characterizing compounds, especially isomeric natural products, here we measured and compared the traveling-wave IMS-derived nitrogen CCS values for 75 marine-derived aphidicolanes. We established a CCS database for these compounds which contained 227 CCS values of different adducts. When comparing the CCS differences, 36 of 57 pairs (over 60%) of chromatographically neighboring compounds showed a ΔCCS over 2%. What is more, 64 of 104 isomeric pairs (over 60%) of aphidicolanes can be distinguished by their CCS values, and 13 of 18 pairs (over 70%) of chromatographically indistinguishable isomers can be differentiated from the mobility dimension. Our results strongly supported CCS as an important parameter with good orthogonality and complementarity with retention time. CCS is expected to play an important role in distinguishing complex and diverse marine natural products.
Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer
Authors: Ho Chang-Hsun , Chen Mei-Lin , Huang Hau-Lun , Lai Chih-Jen , Liu Chih-Hsin , Chuu Chih-Pin , Lin Yu-Hsin
Published: August 2022

The standard of care for prostate cancer (PCa) is androgen deprivation therapy (ADT). Although hormone-sensitive PCa is curable by ADT, most conditions progress to castration-resistant prostate cancer (CRPCa) and metastatic CRPCa (mCRPCa). Front-line docetaxel has been administered to patients with CRPCa and mCRPCa. Nevertheless, docetaxel resistance after half a year of therapy has emerged as an urgent clinical concern in patients with CRPCa and mCRPCa. We verified the mechanism by which docetaxel-resistant PCa cells (DU/DX50) exhibited significant cell migration and expression of malignant tumor-related proteins. Our study shows that the biological activity of fucoidan has an important application for docetaxel-resistant PCa cells, inhibiting IL-1R by binding to P-selectin and reducing the expression levels of NF-κB p50 and Cox2 in this metastasis-inhibiting signaling pathway. Furthermore, the combined treatment of fucoidan and docetaxel showed significant anticancer and synergistic effects on the viability of DU/DX50 cells, which is relevant for overcoming the current limitations and improving treatment outcomes. Overall, fucoidan-based combination chemotherapy may exert beneficial effects and facilitate the treatment of docetaxel-resistant PCa.
Coronary Artery Disease in Women: Lessons Learned from Single-Center SPECT Registry and Future Directions for INOCA Patients
Authors: Vitola Barbara , Trusinskis Karlis , Mintale Iveta , Kalnina Marika , Erglis Andrejs
Published: August 2022

Background and objectives: Myocardial perfusion imaging with cardiac single-photon emission tomography (SPECT) is widely available for the detection of coronary artery disease (CAD) with high diagnostic and prognostic accuracy for women. A large proportion of symptomatic women with true myocardial perfusion defects in SPECT referred to coronary angiography have an absence of CAD—a condition named INOCA (ischemia with nonobstructive CAD). Additionally, the INOCA endotypes are rarely correctly diagnosed, and therefore, no tailored therapy is prescribed. Materials and methods: The cardiac SPECT for women was performed from 2018 to 2021. Patients with perfusion defect were analyzed according to further prescribed diagnostic tests used to diagnose CAD. According to the diagnostic criteria, patients with INOCA were selected as candidates for invasive microvascular physiology measurements. The correlation was calculated between SPECT results and clinical characteristics, symptoms, and risk factors. Results: A total of 726 women with suspected CAD were analyzed. True myocardial perfusion defects were detected in 125 patients (17.2%). During coronary angiography in 70 (56.0%) women, atherosclerosis in epicardial arteries was not observed. In 17 (20.9%) patients, obstructive CAD was present. Correlation was found between perfusion defect in SPECT and cardiovascular risk factors, including overweight, obesity, arterial hypertension, and dyslipidemia. Women with typical angina were more likely to have INOCA, but with “noncardiac” symptoms—CAD. In total, 68 female patients met three inclusion criteria for INOCA and were selected as candidates for invasive diagnostic testing. Conclusions: The created registry proves the important role of cardiac SPECT and great need for the development of invasively detected physiological measurements. The combination of both interventions could significantly change the future directions for INOCA patients, improving treatment strategies and clinical outcomes, especially knowing the number of risk factors and varying clinical presentation. The study will be continued by performing invasive testing of coronary microvascular function to expand the competence about what is known about INOCA patients.
High Versus Low Ligation of the Inferior Mesenteric Artery in Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis
Authors: Kim Kwangmin , An Sanghyun , Kim Myung Ha , Jung Jae Hung , Kim Youngwan
Published: August 2022

Background and Objectives: This study aimed to compare the effects of high ligation (HL) versus low ligation (LL) in colorectal cancer surgery. Materials and Methods: We performed a comprehensive search using multiple databases (trial registries and ClinicalTrials.gov), other sources of grey literature, and conference proceedings, with no restrictions on the language or publication status, up until 10 March 2021. We included all parallel-group randomized controlled trials (RCTs) and considered cluster RCTs for inclusion. The risk of bias domains were “low risk,” “high risk,” or “unclear risk.” We performed statistical analyses using a random-effects model and interpreted the results according to the Cochrane Handbook for Systematic Reviews of Interventions. We used the GRADE guidelines to rate the certainty of evidence (CoE) of the randomized controlled trials. Results: We found 12 studies (24 articles) from our search. We were very uncertain about the effects of HL on overall mortality, disease recurrence, cancer-specific mortality, postoperative mortality, and anastomotic leakage (very low CoE). There may be little to no difference between HL and LL in postoperative complications (low CoE). For short-term follow-up (within 6 months), HL may reduce defecatory function (constipation; low CoE). While HL and LL may have similar effects on sexual function in men, HL may reduce female sexual function compared with LL (low CoE). For long-term follow-up (beyond 6 months), HL may reduce defecatory function (constipation; low CoE). There were discrepancies in the effects regarding urinary dysfunction according to which questionnaire was used in the studies. HL may reduce male and female sexual function (low CoE). Conclusions: We are very uncertain about the effects of HL on survival outcomes, and there is no difference in the incidence of postoperative complications between HL and LL. More rigorous RCTs are necessary to evaluate the effect of HL and LL on functional outcomes.
Acute Obturator Externus Injury in Professional Soccer Players: A Case Series
Authors: Rhim Hye Chang , Gureck Ashley E. , Jang Ki-Mo
Published: August 2022

When patients present with hip or groin pain, proximal quadriceps or adductor injuries are often initially suspected. In this case report, however, we present three cases of professional soccer players who were found to have obturator externus injury. A 30-year-old player and a 24-year-old player complained of pain in the left side after long distance shooting during an in-season training session and a match, respectively. Another 24-year-old player complained of pain in the right side after long distance passing during a preseason training session. On physical examination, active hip external rotation and passive hip internal rotation and extension elicited pain in all three players. All three players underwent magnetic resonance imaging (MRI) which found obturator externus grade II injuries for two players and grade I injury for one player. Rehabilitation protocols included relative rest, cryotherapy, and electrotherapy over a period of one week. All patients were able to return to play after 10 days. Correct identification of obturator externus injury afforded our players a favorable prognosis and a relatively quick return-to-sport compared with quadricep or adductor injury.
Introduction, Spread and Impact of the SARS-CoV-2 Omicron Variants BA.1 and BA.2 in Cyprus
Authors: Richter Jan , Koptides Dana , Tryfonos Christina , Alexandrou Denise , Christodoulou Christina
Published: August 2022

The aim of this study was to investigate and obtain insights into the appearance, spread and impact of the Omicron variants and their sub-lineages in Cyprus by analyzing 611 high-coverage full-genome sequences for the period from November 2021 until April 2022. All viruses sequenced were identified to belong to either Delta (B.1.617.2) or Omicron (lineage BA.1 and BA.2, respectively), with a variety of different sub-lineages. A detailed analysis of the mutational profile is presented and discussed. The Omicron variant BA.1 was shortly followed by BA.2; despite emerging against a background of high vaccination (81% of adult population) and pre-existing natural immunity, they gave rise to the largest waves of infection, with daily numbers rising dramatically, highlighting their increased ability for immune evasion. Within a period of only five months, the percentage of the Cypriot population with a confirmed infection increased from ~15% of the total population to >57%. Despite unprecedented case numbers, a significant reduction in hospital burden and mortality was observed. Our findings highlight the role of the importation of new variants through travel and demonstrate the importance of genomic surveillance in determining viral genetic diversity and the timely identification of new variants for guiding public health intervention measures.