bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepção de estudantes e merendeiras do Programa Nacional de Alimentação Escolar sobre o comer na escola
Authors: Santos Franciele Nascimento dos , Carneiro Everton Nery
Published: March 2023

O Programa Nacional de Alimentação Escolar (PNAE) é um dos programas mais consistentes no que se refere à alimentação e nutrição e tem se configurado como uma importante estratégia de segurança alimentar e nutricional para milhões de estudantes brasileiros. Nesse sentido, para além de atender as necessidades biológicas dos beneficiários, a alimentação escolar também assume uma função sociocultural. Portanto, o estudo tem como objetivo compreender a percepção dos estudantes e merendeiras do Território do Sisal, Bahia, sobre o comer na escola a partir do PNAE. Para o desenvolvimento do estudo foi utilizada a pesquisa aplicada, descritiva, do tipo participante, com abordagem qualitativa, a partir do método fenomenológico. Foram entrevistados 11 estudantes e 7 merendeiras e os dados foram analisados através do percurso gerativo de sentido da perspectiva semiótica. A partir da análise foi possível observar que tanto as merendeiras como os estudantes percebem a alimentação escolar principalmente no seu sentido biológico de satisfazer a fome, mas também compreendem os sentidos simbólicos da alimentação, sobretudo quando relacionam as preferências alimentares aos hábitos regionais.
Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance
Authors: Butti Ramesh , Khaladkar Ashwini , Bhardwaj Priya , Prakasam Gopinath
Published: March 2023

The context-dependent reciprocal interaction between the cancer cells and surrounding fibroblasts is imperative for regulating malignant potential, metabolic reprogramming, immunosuppression, and ECM deposition. However, recent evidence also suggests that cancer-associated fibroblasts induce chemoresistance in cancer cells to various anticancer regimens. Because of the protumorigenic function of cancer-associated fibroblasts, these stromal cell types have emerged as fascinating therapeutic targets for cancer. However, this notion was recently challenged by studies that targeted cancer-associated fibroblasts and highlighted the underlying heterogeneity by identifying a subset of these cells with tumor-restricting functions. Hence, it is imperative to understand the heterogeneity and heterotypic signaling of cancer-associated fibroblasts to target tumor-promoting signaling processes by sparing tumor-restricting ones. In this review, we discuss the heterogeneity and heterotypic signaling of cancer-associated fibroblasts in shaping drug resistance and also list the cancer-associated fibroblast-targeting therapeutics.
Acyl transfer-enabled catalytic asymmetric Michael addition of α-hydroxy-1-indanones to nitroolefins
Authors: Xu Zhi-Hua , Li Na , Chang Zhe-Ran , Hua Yuan-Zhao , Xu Li-Ping , Jia Shi-Kun , Wang Min-Can , Mei Guang-Jian
Published: March 2023

We report herein an enantioselective acyl transfer protocol via electrophile activation. The reaction cascade sequence encompasses dinuclear zinc-catalyzed asymmetric Michael addition, intramolecular cyclization, and retro-Claisen reaction, which leads to a step- and atom-economic approach to a variety of protected cyclic tertiary α-hydroxyketones in good yields with excellent enantioselectivities (24 examples, 56%-82% yield, 1.5-13 dr and 79%-96% ee). Besides, the large-scale synthesis and further transformation of the products demonstrate the effectiveness of this method for organic synthesis.
Performance Comparison of the Cogent Confabulation Classifier with Other Commonly Used Supervised Machine Learning Algorithms for Bathing Water Quality Assessment
Authors: Ivanda Antonia , Šerić Ljiljana , Braović Maja , Stipaničev Darko
Published: March 2023

The purpose of this study was to implement a reliable model for bathing water quality prediction using the Cogent Confabulation classifier and to compare it with other well-known classifiers. This study is a continuation of a previously published work and focuses on the areas of Kaštela Bay and the Brač Channel, located in the Republic of Croatia. The Cogent Confabulation classifier is a thorough and simple method for data classification based on the cogency measure for observed classes. To implement the model, we used data sets constructed of remote sensing data (band values) and in situ measurements presenting ground-truth bathing water quality. Satellite data was retrieved from the Sentinel-3 OLCI satellite and it was atmospherically corrected based on the characteristics and specifications of band wavelengths. The results showed that the Random Forest, K-Nearest Neighbour, and Decision Tree classifiers outperformed the Cogent Confabulation classifier. However, results showed that the Cogent Confabulation classifier achieved better results compared to classifiers based on Bayesian theory. Additionally, a qualitative analysis of the four best classifiers was conducted using spatial maps created in the QGIS tool.
Risk Prediction of Digital Human Resource Management Based on Artificial Intelligence
Authors: Hu Yongda
Published: March 2023

The latest information technologies have greatly accelerated the digitalization progress of Human Resource Management (HRM) and many useful techniques and tools have been developed for that purpose. However, in terms of risk management, effective enough tools and methods are still insufficient. Existing studies generally fail to give a turnkey solution to the operational risks in digital HRM system, and the macro measurement models are not suitable for dealing with the risks in the digital HRM system of each single enterprise. In view of these defects, this paper studied the prediction of risks in digital HRM systems based on Artificial Intelligence (AI). Firstly, the paper outlined the functions of a digital HRM system, defined the risk management mechanism of a HRM system, and built a conceptual model for it. Then, this paper proposed a novel method for predicting the risks in the digital HRM system, which innovatively integrates the digital HRM risk event chains with the risk event graph. After that, the paper elaborated on the structures and building principles of the risk event representation layer, risk event chain module, risk event graph module, and attention fusion module. At last, experimental results verified that the proposed model has obvious advantages in digital HRM risk prediction in terms of both stability and accuracy.
Production and Nutritive Value of Indigofera zollingeriana and Leucaena leucocephala in Peatland
Authors: Ali A , Abdullah Luki , Karti P.M.D.H , Chozin M.A. , Astuti D.A.
Published: March 2023

Abstract. This study was aimed to determine and compare the dry matter yield and nutrient content of Indigofera and Leucaena grown in peatland. This experiment was conducted in peatland type soil (type sapric) in Pekanbaru city, DM yield and nutrient contents data were analyzed by 2x3 factorial design with 3 replication. Two treatments compared were Indigofera zollingeriana (Indigofera) and Leucaena leucocephala (Leucaena). Indigofera was proven significantly higher than Leucaena in all harvest regarding dry matter (DM) of leaf and stem of 29.9% and 25%, respectively, crude protein (CP) of 23.1% and 17.6%, respectively. While neutral detergent fibre (NDF) and acid detergent fibre (ADF) content of Indigofera leaf (35.9% and 25.1%, respectively) was significantly lower than those of Leucaena leaf (40.9% and 29.3%, respectively). It was concluded that the production and nutritive value of Indigofera zollingeriana was superior to Leucaena leucocephala in peatland (type sapric). Key words: Legume tree, Sapric, nutrient content, In vitro digestibiliy              Abstrak.  Penelitian ini bertujuan menentukan dan membandingkan bahan kering dan kandungan nutrisi Indigofera dan Leucaena yang tumbuh di lahan gambut. Percobaan ini dilakukan di lahan gambut di Pekanbaru menggunakan pola faktorial 2x3 dengan ulangan 3 kali. Dua perlakuan yang dibandingkan adalah Indigofera zollingeriana (Indigofera) dan Leucaena leucocephala (Leucaena). Indigofera terbukti secara nyata lebih tinggi daripada Leucana di semua periode panen, berkaitan dengan kandungan BK (bahan kering) daun dan batang berturut-turut 29,9% dan 25%, dan protein kasar (PK) 23,1% dan 17,6%. sedangkan neutral detergent fibre (NDF) dan acid detergent fibre (ADF) daun indigofera berturut-turut 35,9% dan 25,1%, lebih rendah secara nyata daripada daun Leucaena, yaitu 40,9% dan 29,3%. Disimpulkan bahwa produksi dan nilai nutrisi Indigofera zollingeriana lebih tinggi dari Leucaena leucocephala di lahan gambut (jenis saprik) Kata kunci: Pohon legume, Saprik, Kandungan Nutrisi, Kecernaan in vitro
The Effect of Turmeric (Curcuma domestica) Extract on Water Holding Capacity, Cooking Loss, pH Values and Tenderness of Broiler Chicken Meat
Authors: Negari Indira Putri , Isroli Isroli , Nurwantoro Nurwantoro
Published: March 2023

Abstract.  This study was aimed to determine the influences of turmeric extract supplementation on water holding capacity, cooking loss, pH value and tenderness of broiler chicken meat Data analysis was subject to completely randomized design 5 treatments namely T0, T1, T2, T3 and T4 containing non-turmeric extract, 100 mg/kgBW/day, 200 mg/kgBW/day, 300 mg/kgBW/day and 400 mg/kgBW/day, respectively. Each unit of experiment administered 3 heads with four replications. The results indicated no effect from turmeric extract supplementation on water holding capacity, cooking loss, pH value and tenderness of broiler chicken meat. The average treatments of T0, T1, T2, T3, T4 had water holding capacities of  39.86, 37.58, 36.41, 36.94, respectively; cooking losses of 26.00, 27.58, 27.57, 27.11, and 27.49%, respectively; tenderness of 1.97, 1.95, 1.63, 1.77 and 1.99 Nmm, respectively, and final Body weights of 1,618.5, 1,568, 1,692.5, 1,651.75 and 1,462 g/head, respectively. However, a highly significant influence was observed on the pH values of 6.46, 6.04, 6.21, 6.08 and 5.98. The results indicated that none of the turmeric extract supplementation increased water holding capacity, cooking losses, tenderness and body weight. Key words: broiler, cooking loss, pH values, tenderness, water holding capacity, turmeric Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak kunyit terhadap daya ikat air, susut masak, nilai pH dan keempukan daging ayam broiler. Manfaat penelitian yaitu tersedianya informasi ilmiah tentang ekstrak kunyit terhadap danging ayam broiler. Perlakuan yang diterapkan adalah T0 tanpa ekstrak kunyit, T1 100, T2 200, T3 300, dan T4 400 mg/kgBB/hari. Data analisis yang digunakan adalah rancangan acak lengkap yang terdiri dari 5 perlakuan dan 4 replikasi. Setiap unit percobaan terdiri dari 3 ekor. Hasil penelitian menunjukkan tidak ada pengaruh pemberian ekstrak kunyit terhadap daya ikat air, susut masak, dan keempukan daging ayam broiler. Rataan untuk perlakuan T0, T1, T2, T3, T4 pada Daya Ikat Air masing–masing 39,86; 37,58; 36,41; 36,94; 34,78%; susut masak 26,00; 27,58; 27,57; 27,11; 27,49%, keempukan 1,97; 1,95; 1,63; 1,77; 1,99 Nmm, dan bobot badan akhir 1.618,5; 1.568; 1.692,5; 1.651,75; 1.462g/ekor. Namun, memberikan pengaruh sangat nyata pada nilai pH 6,46; 6,04; 6,21; 6,08; 5,98. Hasil  menunjukkan bahwa pemberian ekstrak kunyit  tidak meningkatkan daya ikat air, susut masak, keempukan dan bobot badan. Kata Kunci : Broiler, Susut Masak, pH, Keempukan, Daya Ikat Air, Kunyit
Farmers’ Perception to The Role of Extension Workers on Kaligesing Goat Farm Management in Kaligesing, Purworejo
Authors: Guntoro Budi , Wahyudi Wahyudi , Sulastri Endang
Published: March 2023

Abstract. The aims of this research were to describe the characteristics of Kaligesing goat farmers; to analyze the farmers’ perceptions on the role of extension workers as conduit of information, as mentors, organizers and dynamic factor, technicians and liaisons; to discover the relationship between the farmers’ characteristics with farmers’ perceptions; and to investigate the relationship between farmers’ perceptions to goat maintenance management. The respondents were goat farmers in Kaligesing, Purworejo, Central Java Province. Data were obtained from questionnaire survey method. Determining location, the research applied combination of stratified sampling method with purposive random sampling. Total respondents were 159 farmers with nine farmer groups as samples. Analysis was subject to Spearman Rank, resulting that age, education level and farming experience were not significant to the farmers’ perceptions to the role of extension workers, but the ownership of livestock had a very significant relationship with a correlation coefficient of 0.240, group classes had also very significant relationship with a correlation coefficient of 0.414, and frequency of meeting with extension workers have a significant relationships with a correlation coefficient of 0.202. Farmers’ perceptions to the role of extension workers had very significant relationships to the maintenance management with a correlation coefficient of 0.393. Key words : farmers’ characteristics, farmers’ perceptions, Kaligesing goat, role of extension workers Abstrak. Penelitian ini bertujuan untuk mengetahui karakteristik peternak, persepsi peternak terhadap peran penyuluh, hubungan antara karakteristik peternak dengan persepsi, dan hubungan antara persepsi peternak dengan manajemen pemeliharaan. Responden penelitian adalah peternak Kambing Kaligesing di Kecamatan Kaligesing Kabupaten Purworejo Jawa Tengah dengan metode penelitian survei kuesioner. Penentuan lokasi penelitian dengan kombinasi cara stratified sampling dan purposive random sampling. Jumlah kelompok tani sebagai sampel penelitian sebanyak sembilan kelompok dan jumlah total responden sebanyak 159 peternak. Analisis Rank Spearman digunakan untuk analisis data.  Hasil analisis menunjukkan  bahwa umur, tingkat pendidikan dan lama beternak tidak secara nyata memiliki hubungan dengan persepsi peternak terhadap peran penyuluh, sedangkan kepemilikan ternak memiliki hubungan sangat nyata (P<0,01) dengan nilai koefisien korelasi 0,240. Kelas kelompok memiliki hubungan sangat nyata (P<0,01) dengan nilai koefisien korelasi 0,414 dan frekuensi bertemu penyuluh memiliki hubungan nyata (P<0,05) dengan nilai koefisien korelasi 0,202. Persepsi peternak terhadap peran penyuluh memiliki hubungan sangat nyata (P<0,01) terhadap manajemen pemeliharaan dengan nilai koefisien korelasi 0,393Kata kunci:  karakteristik peternak, persepsi peternak, kambing Kaligesing, peran penyuluh
Quality Evaluation of Complete Feed with Ramie Waste Added With Different Protein Source in Nutrient Composition and Ensilage Parameter
Authors: Susanti Emmy , Agus Ali , Suraningdyah Yuni , Suhartati FM
Published: March 2023

Abstract.  The objective of this research was to evaluate the effect of ensilage technology (with and without ensilage) and protein sources (plant and animal) in complete feed with ramie-waste on nutrient composition and ensilage parameter. Ensilage process decreased significantly dry matter (DM), organic matter (OM) and neutral detergent fiber (NDF), but it increased  ensilage parameter i.e. acetate acid (C2), propionic acid (C3), butyric acid (C4), lactic acid (LA), and decreased pH. It also had non-significant effect on crude fibre (CP), acid detergent fiber (ADF) and ammonia (NH3-N). Animal protein source in silage making decreased nutrient composition i.e. OM and CP and ensilage parameter i.e. C2, but it increased NH3-N.  Interaction between ensilage treatment and protein sources affected CP and pH also ensilage parameter of C2 and C3. In conclusion, plant protein used in silage of complete feed with ramie waste was better than animal protein, despite that both ensilage were not better due to pH over 4.5. Key words: ramie, ensilage technology, protein source, nutrient composition, ensilage parameter Abstrak. Penelitian ini bertujuan mengevaluasi pengaruh teknologi ensilage (dengan dan tanpa ensilage) dan sumber protein (nabati dan hewani) pada complete feed menggunakan limbah rami terhadap komposisi nutrien dan parameter ensilage. Perlakuan teknologi ensilage menurunkan komposisi nutrien pada bahan kering (BK), bahan organik (BO) dan neutral detergent fiber (NDF, meningkatkan kuantitas parameter ensilage pada asam asetat (C2), asam propionat (C3), asam butirat (C4) dan asam laktat (LA) dan menurunkan pH serta tidak nyata pada protein kasar (PK), acid detergent fiber (ADF) dan ammonia (NH3-N).  Perlakuan sumber protein menurunkan nutrien BO dan PK dan C2 serta meningkatkan konsentrasi NH3-N secara sangat nyata pada complete feed dengan protein hewani. Interaksi kedua perlakuan berpengaruh pada PK dan pH serta C2 dan C3. Kesimpulannya adalah penggunaan protein nabati pada silage complete feed menggunakan limbah rami lebih baik dari pada yang menggunakan protein hewani meskipun kedua jenis silage tidak lebih baik karena pH lebih dari 4,5. Kata kunci: rami, teknologi ensilage, sumber protein, komposisi nutrien, parameter ensilage
The Diversity and Productivity of Indigenous Forage in Former Limestone Mining Quarry in Karst Mountain of Southern Gombong, Central Java Indonesia
Authors: Sarwanto Doso , Prayitno Caribu Hadi
Published: March 2023

Indonesia is a country that has a lot of limestone mountains, covering 15.4 million hectares. Limestone mountains have strategic functions as limestone is used as building materials and as raw material in cement industry. Therefore, limestone mining quarry in various areas of limestone mountains in Indonesia is increasingly widespread. The biggest negative impact of limestone mining is the formed open land which is abandoned and unutilized. Changes in the ecosystem will lead to the reduced levels of diversity and productivity of indigenous forage which will ultimately reduce the performance and development of ruminants livestock kept by farmers in the mountainous region of limestone. This study aims to determine the diversity and productivity of indigenous forage on former limestone mining quarry in limestone mountains of southern Gombong. The research was conducted through survey by identifying and measuring the forage production of sample plots assigned purposively. Location of the study was divided into three categories, mild, moderate and heavy mining. Results showed that soil fertility levels in open fields of former limestone mining in southern Gombong mountains are low with total N content of 0.049 - 0.141%, total P2O5 of 0.067 - 0.133% and total K2O of 0.086 - 0.100%. The diversity of indigenous forage on mild mining was more diverse than that of moderate and heavy mining, i.e. 13 species comprising 7 grass species, 2 legumes species, and 4 species of shrubs. The most dominant species in all mining categories are Cynodon dactylon, Imperata cylindrica, Ageratum conyzoides and Mikania micrantha. The results also showed that in the open land of mild mining had the highest production of fresh and dry matter compared to that of moderate and severe mining
Grazing Behavior and Itineraries of Kacang Goat with Different Coat Color under Semi Intensive Management
Authors: Kiswanto Slamet Heri , Baihaqi Muhammad , Prihantoro Iwan
Published: March 2023

The objective of this research was to analyze the effect of coat color on behavior and itineraries of kacang goat during grazing time. This research used 9 females and 3 males kacang goat. Behavior observed by one zero sampling method and analyzed using t-Test at level 5%. The result indicated that ingestion and browsing of brown goat (30.91±2.87%; 8.75±3.10%) higher than black goat (28.57±2.69%; 6.07±4.78%), while black goat showed more locomotion (33.26±4.50%) than brown goat (29.70±4.63%). Grazing, panting, and resting behaviors, and distance traveled of black goat (22.56±2.63%; 4.48±4.02%; 2.34±2.97%; 483.48±133.16 m) were not different with brown goat (22.16±2.90%; 4.59±3.71%; 2.64±1.52%; 392.29±81.19 m). Result also  indicated that goat showed more grazing than browsing with high preference in you ng grass than old grass,  legume, and weed.
The Efficacies of Banana Stem Extract as a Candidate of Coccidiostat Against Rabbit Eimeria Stiedaio Ocysts: an in Vitro Analysis
Authors: Indrasanti Diana , Indradji Mohandas , Hastuti Sri , Wihadmadyatami Hevi , Ismoyowati Ismoyowati
Published: March 2023

The objective of this research was to investigatethe ability of banana stem (Musa paradisiaca) to inhibitsporulation of Eimeria stiedaioocystsderived fromrabbit by in vitroanalysis.Analyze the active substance proximate analysis and active substancesin this research were performed too. Banana stem extract were used in this experiment andsulfaquinoxalline(Coxy ®)was run as acontrol. The Eimeria stiedaioocystswere incubated prior the presence of  different concentration from banana stem extract  0%, 1%, 2%, 4%, 8%for 1, 2 and 3 daysat 26°C. In addition,Factorial patterned Completely Randomized Design (CRD) with five replicates wasapplied on the experiment. Result analysis was performed by using Analysis of Variance and following by Honestly Significant Difference (HSD) post hoc test. Here, we identified that banana stem extract contain different type of active substance such as tannin, saponin, and alkaloid. Banana stem extract significantly affected the oocysts sporulation included the amount of sporulatedoocysts (P<0.01), unsporulatedoocysts (P<0.01), and transformed oocysts (P<0.01). In conclusion banana stem could inhibit the development of Eimeria stiedaioocysts on in vitroexperiment. HSD test showed that the optimum potential efficacy of banana stem toinhibit sporulation was at 4% and 8% concentration during three days incubation.
Particle Size's Effect of Application Forage Processing Technology on Consumption Efficiency, Palatability and Digestibility of Local Goat
Authors: Iswarin Retno , Fani Furiska , Pambudi Andre Wira
Published: March 2023

Livestock's digestible feed ability is affected by the physical and chemical quality of the feed given. Study feed processing application on a local goat feed particle size needs to be done for efficiency of feeding patterns. This study aimed to evaluate the best forage particle size on efficiency consumption, palatability and digestibility of the local goat. The experimental method was done with randomized completely block design with 3x2x3 factorial. Goats are grouped by weight, the first factor is the form of feed (fresh, dried) with particle feed size of 3 - 5 - > 7 cm as the second factor. The results showed that particle size of > 7 cm gives the optimal feed consumption and palatability. Dry and organic materials digestibility provided the best on the particle size of 3 cm. Forms of dry feed has a positive correlation with consumption, palatability and digestibility of feed. Conclusion of the study recommended dried forage given to the local goats with a particle size of 3 cm is able to provide efficiency in consumption and palatability of the feed with the most excellent digestibility.
Chemical Properties and Characteristics of Cow Milk Yogurt with Different Additional Fruit and Storage Time
Authors: Wulansari Putri Dian , Kusmayadi Andri
Published: March 2023

This research was aimed to evaluate the composition (total solids, water content, fat and protein), qualitative properties (color, aroma, and texture) and quantitative properties (free fatty acid and lactic acid) of cow milk yogurt with different fruits addition and storage time. Experimental method applied Completely Randomized Design with five treatments namely control, dragon fruit, mango, apple and banana (20% v/v), each with 5 replicates. Qualitative characteristic assessment was conducted on 0, 5, 10 and 15 days of storage. Result showed that fruit addition significantly affected the composition and characteristics, while storage time significantly affected quantitative characteristics of yogurt. Apple and banana increased 13% total solids of plain yogurt, while the highest fat content (4,516%) was observed in control yogurt which had the lowest protein content (2,564). The highest free fatty acid  was in control yogurt ripen for 15 days (22,885%) while the lowest free fatty acid was in mango yogurt ripen for 10 days (13,915%). Fruit addition in yogurt ripen for 15 days at 5C resulted in a safe consumed product.
Raw Semen Characteristics of Three Different Indonesian Local Roosters
Authors: Hambu Emilia Kamung , Arifiantini Raden Iis , Purwantara Bambang , Darwati Sri
Published: March 2023

Indonesia has agreat variety of roosters, either indigenous type as well as exotic and cross breed. The purpose of this experiment was to study the characteristics of semen from three types of Indonesian local roosters such as Merawang, Kampung and crosses Sentul Kampung with Kedu (SK Kedu). A total of 15 roosters consist of  Merawang roosters,  Kampung, and SK Kedu roosters were 5 each. The semen was collected 3 times a week by dorso-abdominal and cloaca massage method. The parameters evaluation was macroscopic characteristics consist of volume, color, consistency, and pH. Microscopic evaluation of semen such as a mass movement, sperm motility, live sperm, sperm abnormality and sperm concentration. Results of this experiment showed that semen volume of  Merawang  (0.40±0.26 mL) was higher (p<0.05) compare to Kampung (0.24±0.12 mL) or  SK Kedu (0.16±0.10 mL) but no difference on semen color, consistency and semen pH. There were no difference in the mass movement, sperm motility and live sperm as well as on sperm abnormality among three types of roosters.  Sperm  concentration of Merawang (4490 million mL-1) was significantly higher than Kampung (3245 million mL-1) and the SK Kedu roosters (3751 million mL-1). Its was conclude that Merawang roosters had good semen quality better than Kampung and SK Kedu roosters
Ointment Formulation of Arumanis Mango (Mangifera indica L.) Leaf Extract with Chitosan Tripoliphosphate Matrix as Antibacterial
Authors: Ningsih Dian Riana , Riapanitra Anung , Zusfahair Zusfahair , Sulaeman Uyi , Khoeriyah Istinganatun
Published: March 2023

This report presented the synthesis of Arumanis mango (Mangifera indica L.) leaf extract with chitosan tripolyphosphate matrix and its antibacterial activity. This research aimed to obtain an ointment formulation from mango leaf extract with chitosan tripolyphosphate matrix, to figure out the characteristics, including the particle morphology, and to determine the optimum formulation and the characterization of the antibacterial ointment. The research showed that extract morphology with chitosan tripolyphosphate was uneven-edge aggregates. Antibacterial tests were conducted on P. acnes and E. coli bacteria. The formula giving the greatest antibacterial activity was further utilized for the ointment preparations and then was characterized for 16 days. Formula C (chitosan and NaTPP  1: 0.0992(%)) gave the most excellent inhibition zone for P. acnes and E. Coli bacteria, at 7.94 mm and 10.02 mm, respectively. The obtained ointment preparation was white color homogeneous semi-solid with protective properties. The spreading power of the ointment was 5.25 – 6.25 cm, with the adhesive power of 1 – 5 seconds and pH of 6.0 – 6.4. The ointment's antibacterial activity was tested against P. acnes and E. coli bacteria using the formation of  inhibition zone method. The activity of ointment prepared on day one against P. acnes and E. coli was at 14.03 mm and 14.24 mm, respectively, while the activity on day 16 against P. acnes and E. coli was at 9.33 mm and 9.98 mm, respectively.
Bioactivity of Endophytic Fungi Isolated from Branch of Jambu Mawar (Syzygium jambos (L.) Alston)
Authors: Aini Kurratul , Elfita Elfita , Widjajanti Hary , Setiawan Arum
Published: March 2023

Endophytic fungi isolated from medicinal plants have high diversity and the secondary metabolites produced have biological activity. Endophytic fungi isolated from medicinal plants have been the subject of many studies on their diversity and biological activity, one of which is jambu mawar (Syzygium jambos (L.) Alston). S. jambos has long been used as a traditional medicine to treat infections caused by pathogenic bacteria in many parts of the world, including South Sumatra. This study purposed to explore the diversity of endophytic fungi isolated from the branches of S. jambos, the antibacterial activity of endophytic fungi extracts, the determination of the structure of the compounds, and the activity of the active compounds of the selected endophytic fungi. Observations of the morphological characteristics of endophytic fungi were macroscopically and microscopically. The endophytic fungal extracts were then tested for antimicrobial activity against test bacteria Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, and Escherichia coli using the Kirby-Bauer paper disk diffusion method. Isolation of pure compounds using a gravity chromatography column, the determination of the structure of the compound is determined based on 1H-NMR, 13C-NMR, HMQC, and HMBC spectroscopy. Four endophytic fungi, code SJC1–4, were isolated from a branch of S. jambos. The results of macroscopic and microscopic morphological characterization showed three genera of Botryosphaeria, Trichothecium, and Aspergillus. The endophytic fungal isolate SJC1 exhibited strong activity against Gram-positive bacteria and moderate activity against Gram-negative bacteria, while SJC2–4 showed moderate activity against the four bacteria. Molecular identification of SJC1 revealed that it was Botryosphaeria mamane. Isolation of SJC1’s pure compound yielded compound 1, which was identified as 5-acetyl-6-hydroxy-3-methyl-2H-pyran-2-one. This compound is thought to have antibacterial properties.
An Insight of Cryptocarya Secondary Metabolites as Anticancer P388: Study of Molecular Docking and ADMET Properties
Authors: Rasyid Herlina , Mardiyanti Riska , Arief Ihsanul , Saputri Wahyu Dita
Published: March 2023

Secondary metabolites isolated from Cryptocarya was known to have various activity especially their cytotoxicity in P388 cell. There were two species of Cryptocarya studied in this research that were Cryptocarya konishii and Cryptocarya lucida. In both species, 8 isolate compounds had bioactivity as anticancer in P388 cells. This study aimed to know the binding affinity and ADMET properties of each isolated compound through P-glycoprotein substrate since this protein was reported to be responsible for the inhibition of P388 cells. Molecular docking was performed using AutoDock4 and AutoDockTools software to know the binding energy and interaction of isolate compounds against the P-glycoprotein substrate. ADMET properties calculation was done using the pkCSM web server for all compounds. Molecular docking results showed that Kurzichalcolactone B (7) isolated from C. lucida had the lowest binding energy. It resulted in the highest total intermolecular energy from the contribution of van der Waals and hydrogen bond energy. The lowest binding energy is indicating the stable interaction of ligand and substrate. Calculation of ADMET properties resulted that some of the isolate compounds fulfilling the minimum standard parameters in ADMET properties.
Photodegradation and Photoelectrodegradation of Methyl Orange and Methyl Violet Dyes using Graphite/PbTiO3 Composite under Visible Light Irradiation
Authors: Purnawan Candra , Wahyuningsih Sayekti , Saputra Ozi Adi , Yulianto Erick Ryan
Published: March 2023

The composite of Graphite/PbTiO3 has been synthesized for photocatalyst and photo-electrocatalyst of Methyl Orange (MO) and Methyl Violet (MV) degradation using a visible light source. The aims of the research were to study the influence of pH of the solution, iradiation time and kinetics study of MO and MV photodegradation, voltage of photoelectrodegradation of MO and MV. Composite of Graphite/PbTiO3 was synthesized by the sol-gel process with Titanium Tetraisopropoxide (TTIP) solution and Pb(NO3)2 powder as the precursors. Graphite/PbTiO3 composite was characterized using X-ray difractometer and FTIR spectrometer. The diffractogram of Graphite/PbTiO3 composite showed peaks at 2θ = 26.507o as a characteristic diffraction of Graphite, and at 2θ = 31.838o and 39.294o as those of PbTiO3. FTIR spectrum of Graphite/PbTiO3 composite exhibits vibration peaks of TiO2 at 609.5 – 420.5 cm-1 and those of Pb-O at 1337.66 cm-1 until 1395.56 cm-1. The photodegradation results showed that Graphite/PbTiO3 composite can degrade MO and MV optimally at a pH = 3. The photodegradation levels of MO and MV were 90.33% and 88.26% for 30 min of visible light radiation, respectively. The photodegradation of MO and MV were following the first-order reaction with a reaction rate constant of 0.4445 min-1 and 0.4244 min-1, respectively. Meanwhile, the photoelectrodegradation of MO was 96.50% at 10 volts and at pH 11, while the photoelectrodegradation of MV was 95.14% at 10 volts and at pH 7. When compared previous research, this result also shows excellent degradation MO and MV using Graphite/PbTiO3 under visible light irradiation. So that the use of visible lights provides an advantage over the use of UV light.
ULUDAĞ ÜNİVERSİTESİ FELSEFE BÖLÜMÜ ÖĞRENCİLERİNİN BÖLÜME YÖNELİK GÖRÜŞLERİ
Authors: ÇÜÇEN Abdulkadir , ŞENGÜL Ahmet Asım
Published: March 2023

Prof.Dr.Abdülkadir ÇÜÇEN

Prof.Dr | Prof.Dr. Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Felsefe Bölümü, Bursa, TR Bursa Uludağ University, Faculty of Arts and Sciences, Department of Philosophy, Bursa, TR ORCID:0000-0001-8092-1472 , kadir@uludag.edu.tr

Ahmet Asım ŞENGÜL

Doktora Öğrencisi | Phd. Candidate Uludağ Üniversitesi, Eğitim Bilimleri Enstitüsü, Fen Eğitimi A.B.D, Bursa, TR Uludag University, Institute of Education Sciences, Department of Science Education, Bursa, TR ORCID: 0000-0001-7555-441X, ahmetasimsengul@gmail.com

Uludağ Üniversitesi Felsefe Bölümü Öğrencilerinin

Bölüme Yönelik Görüşleri

ÖZ: Bu çalışmada, Uludağ Üniversitesi, Fen-Edebiyat fakültesi, Felsefe bölümü 4. Sınıf öğrencilerinden 86 öğrenci katılmıştır. Öğrencilere daha önce geliştirilen anket çalışması uygulanmış. Bu anket sonuçları SPSS ile analiz edilmiştir. Varyansların homojen dağıldığı saptanmış ve alt faktörler belirlenmiştir. 3 faktör elde edilmiştir. Bu faktörler; Kişilik özellikleri, Felsefe Eğitimi ve Meslek Bilgisi olarak kategorize edilmiştir. Bağımsız örneklemeler T testi kullanılarak Kişilik özellikleri ve felsefe eğitimi alt faktörlerinin cinsiyet değişkeni ile aralarında anlamlı bir farklılık bulunamamıştır. Fakat meslek bilgisi alt faktörü ile cinsiyet değişkeni arasından anlamlı bir fark olduğu sonucuna ulaşılmıştır (t=2,38; p,05) ve felsefe eğitimi f(3,82)=4,33 p>,05) alt faktörlerine ilişkin tercih sırası arasından anlamlı bir farklılık olmadığı ortaya çıkmıştır. Uludağ Üniversitesi’ni Tercih etme nedenine ilişkin bulguların analizinde, One Way ANOVA, Tukey testi kullanılmıştır. Bu test sonucuna göre, kişilik özellikleri (f(4,81)=2,22, p>,05) , felsefe eğitimi f(4,81)=,15 p>,05) ve meslek bilgisi f(4,81)=2,38, p>,05). Faktörleri ile Uludağ Üniversitesini tercih etme nedeni arasından anlamlı bir farklılık olmadığı ortaya çıkmıştır.

Anahtar Kelimeler: Felsefe Eğitimi, Uludağ Üniversitesi, Anket, Meslek Bilgisi, Kişilik Özellikleri
Evaluation of 11 properties at Fort Hunter Liggett, California for eligibility to the National Register
Authors: Adams Sunny , Smith Adam , Story Madison
Published: March 2023

The US Congress codified the National Historic Preservation Act of 1966 (NHPA), the nation’s most effective cultural resources legislation to date, mostly through establishing the National Register of Historic Places (NRHP). The NHPA requires federal agencies to address their cultural resources, which are defined as any prehistoric or historic district, site, building, structure, or object. Section 110 of the NHPA requires federal agencies to inventory and evaluate their cultural resources, and Section 106 requires them to determine the effect of federal undertakings on those potentially eligible for the NRHP. Fort Hunter Liggett is in Central California, entirely within Monterey County. It was first established as the Hunter Liggett Military Reservation in 1941. The post was renamed Fort Hunter Liggett in 1975. This report provides a determination of eligibility for nine properties (Buildings 172, 179, 196, 197, 291, 2199, 723, and 914 and facilities 0301BS and radio-controlled aerial target [RCAT]) constructed between 1956 and 1972 and recommends that none are eligible under the NRHP and the California Register of Historic Resources (CRHR) criteria. Two other properties (Buildings 177 and 178) were found to be covered by the Unaccompanied Personnel Housing (UPH) Program Comment of 2006. In consultation with the California State Historic Preservation Officer (CASHPO), this work fulfills Section 110 requirements for these buildings.
Deeplearning-based vehicular channel estimator in high mobility environments
Authors: Abderrahim mountaciri , youssefi my abdelkader , elmostafa makroum
Published: March 2023

In recent years, deeplearning has almost invaded the world of telecom electronics and other fields, given the spectacular results it achieves in terms of improving the performance of digital processing chains. Wireless Access in Vehicle Environments (WAVE) technology has been developed, and IEEE 802.11p defines the Physical Layer (PHY) and Media Access Control (MAC) layer in the WAVE standard. However, the IEEE 802.11p frame structure, which has a low pilot density, makes it difficult to predict wireless channel properties in a vehicle environment with high vehicle speeds (high Doppler frequency), thus system performance are degraded in realistic vehicle environments. The motivation of this article is to improve channel estimation and tracking performance without modifying the IEEE 802.11p frame structure. Therefore, we propose a channel estimation technique based on deeplearning that can perform well over the entire range of SNR values, the effects of ISI and ICI interference remain inescapable phenomena. The improvement brought by the LS channel estimation methods, MMSE and linear equalizers, cubic spline, linear DFT ET and cubic spline DFT interpolation are reviewed, these interpolation techniques contribute to the reduction of the BER in the chain. The different vehicular channel environment scenarios are split, simulations of the new estimation DNN method are performed on examples of high mobility channels, and compared to the LS and MMSE methods. A strong immunity of the proposed estimator against the high mobility of the channels is observed.
Rhinocerebral mucormycosis secondary to acute lymphoblastic leukemia: a case report
Authors: Li Chunmiao , Yi Huanhuan , Wei Bei , Song Dandan , Han Fugen , Seng Dongjie , Zhao Jing
Published: March 2023

Case presentation
An 8-year-old boy was admitted to the Department of Hematology and Oncology of Henan Children’s Hospital on January 25, 2021, with generalized fatigue and pallor for 3 weeks. He was diagnosed with rhinocerebral mucormycosis (RCM) secondary to childhood acute lymphoblastic leukemia. He was put on medication, and a surgical debridement was performed. The patient was followed up for treatment.
Objective: This study aimed to improve the understanding of RCM secondary to childhood acute lymphoblastic leukemia (ALL).
Methods: The clinical data of a patient with RCM secondary to ALL admitted to Henan Children’s Hospital in January 2021 were analyzed, and relevant literature was reviewed.
Result: RCM secondary to ALL is rare and difficult to diagnose and has a suboptimal prognosis.
Conclusions: For fever, nasal mucosal ulceration, and formation of black scab skin in the nasal cavity and oral mucosa in ALL, the possibility of hair mold infection should be considered. Antifungal drugs and surgical treatment should be started as soon as possible.
Histopathologic patterns of salivary gland lesions and associated factors in Jimma university medical center, Jimma, South West Ethiopia
Authors: Ulfata Roba Elala , Getahun Habtamu Abebe , Kedir Abdo
Published: March 2023

Background: Tumors of salivary gland are morphologically and clinically diverse group of neoplasms, which may present considerable diagnostic and management of challenges to the pathologist or surgeons.It account’s about 4% of all epithelial neoplasms in head and neck region. These comprise a wide variety of benign and malignant neoplasms, and non-neoplastic lesions which exhibit a difference in biological behaviors. Therefor it is important to study the morphological patterns of salivary gland neoplastic and non-neoplastic lesions.
Methods and Materials: A retrospective cross-sectional study design was applied for Salivary gland lesions patients diagnosed at Jimma university medical center from September 2016 to August 2020.
Results: from the total of 176 patients 135(76.7%) were neoplastic and the remaining 41(23.3%) were non-neoplastic lesions. Being in the age group of 21-40[odds ratio=5.172, 41-60[odds ratio =4.534], and having the lesions for duration >24 months [odds ratio 12.479] and the size of the mass >5 cm [odds ratio =19.486]were associated increased odds of neoplastic lesions, while the site of the lesions being in major groups of salivary glands [odds ratio=0.056] was associated with decreased likelihood of neoplastic Salivary gland lesions.
Conclusion: The prevalence of neoplastic salivary lesions was three times more common than non-neoplastic ones and malignancies were slightly more common than benign lesions. Mucoepidermoid carcinoma was the commonest malignant while Pleomorphic adenoma was the commonest benign Salivary gland lesions both in females and males. The neoplastic Salivary gland lesions were highly associated with age, duration, tumor size and minor groups of salivary glands.
p53 isoform expression promotes a stemness phenotype and inhibits doxorubicin sensitivity in breast cancer
Authors: Reinhardt Luiza Steffens , Groen Kira , Zhang Xiajie , Morten Brianna , Wawruszak Anna , Avery-Kiejda Kelly
Published: March 2023

In breast cancer, dysregulatedTP53expression signatures are a better predictor of chemotherapy response and survival outcomes thanTP53mutations. Our previous studies have shown that high levels of Δ40p53 are associated with worse disease-free survival and disruption of p53-induced DNA damage response in breast cancers. Here, we further investigated thein vitroandin vivoimplications of Δ40p53 expression in breast cancer. We have shown that genes associated with cell differentiation are downregulated whilst those associated with stem cell regulation are upregulated in invasive ductal carcinomas expressing high levels of Δ40p53. In contrast to p53, endogenous ∆40p53 co-localised with the stem cell markers Sox2, Oct4, and Nanog in MCF-7 and ZR75-1 cell lines. ∆40p53 and Sox2 co-localisation was also detected in breast cancer specimens. Further, in cells expressing a high ∆40p53:p53 ratio, increased expression of stem cell markers, greater mammosphere and colony formation capacities, and downregulation ofmiR-145andmiR-200(p53-target microRNAs that repress stemness) were observed compared to the control subline.In vivo, a high ∆40p53:p53 ratio led to increased tumour growth, Ki67 and Sox2 expression, and blood microvessel areas in the vehicle-treated mice. High expression of ∆40p53 also reduced tumour sensitivity to doxorubicin compared to control tumours. Enhanced therapeutic efficacy of doxorubicin was observed when transiently targeting Δ40p53 or when treating cells with OTSSP167 with concomitant chemotherapy. Taken together, high Δ40p53 levels induce tumour growth and may promote chemoresistance by inducing a stemness phenotype in breast cancer; thus, targeting Δ40p53 in tumours which have a high Δ40p53:p53 ratio could enhance the efficacy of standard-of-care therapies such as doxorubicin.
Lattice gauge theory and topological quantum error correction with quantum deviations in the state preparation and error detection
Authors: Zhao Yuanchen , Liu Dong
Published: March 2023

Quantum deviations or coherent noise are a typical type of noise when implementing gate operations in quantum computers, and their impact on the performance of quantum error correction (QEC) is still elusive. Here, we consider the topological surface code, with both stochastic noise and coherent noise on the multi-qubit entanglement gates during stabilizer measurements in both initial state preparation and error detection. We map a multi-round error detection protocol to a three-dimensional statistical mechanical model consisting of Z_2 gauge interactions and related the error threshold to its phase transition point. Specifically, two error thresholds are identified distinguishing different error correction performances. Below a finite error threshold, in stark contrast to the case with only stochastic errors, unidentifiable measurement errors can cause the failure of QEC in the large code distance limit. This problem can only be fixed at the perfect initial state preparation point. For a finite or small code with distance d, we find that if the preparation error rate is below a crossover scale ~1/log(d), the logical errors can still be suppressed. We conclude that this type of unavoidable coherent noise has a significant impact on QEC performance, and becomes increasingly detrimental as the code distance increases.
Indole-3-methanol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway
Authors: Zhu Fengyu , Li Fangfang , Hu Huiqing , Wang Siyuan , Chen Jiaqi , He Zhuoying , Kang Yumiao , Li Xuqing , Li Hongyan , Zhong Fei
Published: March 2023

Background Ovarian injury is one of the side effects of chemotherapy in female patients, which seriously endangers female reproductive health. Indole-3-carbinol (I3C), a natural substance abundant in cruciferous vegetables, has been reported to attenuate tissue damage. This study aimed to investigate whether I3C could prevent from ovarian damage induced by chemotherapy.
Methods A mouse model of ovarian damage was established by intraperitoneal injection of cisplatin or co-treatment with I3C. Then the ovarian index and estrous cycle was assessed. Meanwhile, follicles counting was conducted to evaluate the effect of I3C in follicular development. Also, we performed the TUNEL and IHC staining to analyze the level of apoptosis and fibrosis, respectively. Western blot and qRT-PCR was used as quantitative methods to evaluate the expression of relative markers and TGF-β1/Smad pathway. Hela cells and Caski cells was used to investigate the anti-tumor activity of I3C by cell counting kit-8, the wound healing assay and colony formation assay in vitro.
Results Our results showed that administration of I3C restored the ovary index and improved estrous cycle disorders. Follicle counting results showed that I3C is able to inhibit primordial follicles over-activation caused by cisplatin treatment, and maintained primordial follicle pool. We also found that I3C can down-regulate the levels of Bax and γH2ax, and inhibit the apoptosis of ovarian granulosa cells. In addition, I3C also reduced ovarian fibrosis and inhibited α-SMA and Collagen I expression levels. Further research revealed that I3C treatment significantly down-regulated the activity of the TGF-β1/smad signaling pathway. Finally, we demonstrated that I3C could inhibit the proliferation, migration and colony formation of cervical cancer cells in vitro.
Conclusions In summary, I3C alleviates primordial follicular over-activation, granulosa cell apoptosis and ovarian fibrosis induced by cisplatin, and exhibits antitumor activity. Our study provides an innovative therapeutic strategy for preventing ovarian function from chemotherapy in female cancer patients.