bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of third-generation EGFR-TKIs in advanced NSCLC with different T790M statuses tested via ddPCR and NGS
Authors: Xu Ziyi , Li Yan , Wang Lin , Hao Xuezhi , Ying Jianming , Li Junling , Xing Puyuan
Published: January 2023

Objective
Third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibiors (TKIs) is the standard strategy for T790M-positive non-small cell lung cancer (NSCLC). We hypothesize that ddPCR, with a higher sensitivity than NGS, would optimize the treatment strategies in EGFR-TKIs relapsed patients. In this study, we compared the efficacy of third-generation TKIs with various T790M statuses via these two assays.
Methods
NGS was performed on blood samples of patients progressed from previous EGFR-TKIs treatment for resistance mechanism. T790M-negative patients received a further liquid biopsy using ddPCR for T790M status detection. The analysis of efficacy and survival for subsequent third-generation EGFR-TKIs was carried out.
Results
A cohort of 40 patients were enrolled from Sept, 2020 to Dec, 2021, with 30.0% (12/40) tested T790M-positive via NGS (Group A). In another 28 T790M-negative patients by NGS, 11 (39.3%) were T790M-positive (Group B) and 17 (60.7%) were T790M-negative (Group C) via ddPCR. After a median follow-up period of 13.7 months, a relatively longer progression-free survival (PFS) was observed in group A (not reached) and group B (10.0 months, 95% CI 7.040-12.889) than in group C (7.0 months, 95%CI 0.000-15.219), with no significant difference across all three groups (P = 0.196), or between group B and Group C (P = 0.412). The detection of EGFR-sensitive comutations correlated with an inferior mPFS (P = 0.041) and objective response rate (p = 0.326), and a significantly lower disease control rate (P = 0.033) in T790M-negative patients via NGS (n = 28).
Conclusion
This study indicates that ddPCR may contribute as a supplement to NGS in liquid biopsies for T790M detection in EGFR-TKIs relapsed patients and help to optimize the treatment strategies, especially for those without EGFR-sensitive comutations.
Cuproptosis-related gene DLAT is a prognostic and immunological biomarker in pan-cancer
Authors: Liping Zeng , Fang Xianlei , Xiaomin Lu , Long Heng , Feng Zhen-Bo
Published: January 2023

Dihydrolipoamide S-acetyltrans-ferase (DLAT), a mitochondrial protein involved in glucose metabolism, has been identified as a key gene associated with cuproptosis recently. However, studies on DLAT in pan-cancer have not been found. Aim of this study is to explore the expression profiles and clinical value of DLAT in pan-cancer. DLAT expression profiles were obtained from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), UALCAN and the Human Protein Atlas (HPA) websites. The prognostic and diagnostic values of DLAT and its relationship with immune cell infiltration were analyzed based on TCGA data. cBioPortal and UALCAN websites were used to search gene alteration and methylation status of DLAT in tumors, respectively. CancerSEA database was used to investigate the biological functions of DLAT at the single-cell level. Finally, STRING, GAPIA2.0 and TIMER databases were used to construct protein-protein interaction (PPI) networks and functional enrichment analyses. High DLAT expression was found in most cancers and predicted poor prognosis in patients with several tumors, such as breast cancer, esophageal cancer, head and neck squamous cell carcinoma. DLAT showed early diagnostic value in 17 tumors, especially in acute myeloid leukemia (LAML). Abnormal gene alterations and DNA methylation of DLAT were verified in pan-cancer. Single cell RNA sequencing (scRNAseq) analysis reflected that DLAT could regulate various biological functions of cancer cells. Abnormal expression of DLAT regulated infiltration of multiple immune cells in a variety of tumors. Gene enrichment analysis showed that DLAT was involved in mitochondrial matrix, coated vesicle and ribonucleoprotein granule. DLAT can be used as an important indicator of early diagnosis, prognosis and immunotherapy for a variety of tumors.
An assessment on the interplay of digital proximity app use and vaccine uptake for SARS-CoV-2 transmission mitigation in Switzerland
Authors: Daniore Paola , Moser André , Höglinger Marc , Hensch Nicole Probst , Imboden Medea , Vermes Thomas , Keidel Dirk , Bochud Murielle , Herrero Natalia Ortega , Baggio Stéphanie , Chocano-Bedoya Patricia , Rodondi Nicolas , Tancredi Stefano , Wagner Cornelia , Cullati Stéphane , Stringhini Silvia , Nusslé Semira Gonseth , Veys-Takeuchi Caroline , Zuppinger Claire , Harju Erika , Michel Gisela , Frank Irène , Kahlert Christian , Albanese Emiliano , Crivelli Luca , Levati Sara , Amati Rebecca , Kaufmann Marco , Geigges Marco , Ballouz Tala , Frei Anja , Fehr Jan , Von Wyl Viktor
Published: January 2023

Introduction
Adherence to digital proximity tracing apps and preventive measures leading up to and following widespread SARS-CoV-2 vaccine rollout remains unclear. Our study aims to evaluate the relative effect of digital proximity tracing app use, SARS-CoV-2 vaccine uptake and adherence to additional preventive measures in a localized context of the pandemic.
Methods
We report findings from two population-based longitudinal cohorts in Switzerland, the Corona Immunitas Digital Follow-up eCohort (CI-DFU) and the COVID-19 Social Monitor (CSM) studies in 2021. Failure time analyses were conducted for each study cohort, stratified by age group. Cox proportional hazards regression models with time-varying covariates were used to estimate adjusted hazard ratios (aHR). The analyses assessed vaccine uptake and SwissCovid app uninstalling outcomes, with the outcomes interchanging as the exposures in two separate substudies.
Results
We observed a dichotomy of individuals who did not use the app during the study period and did not get vaccinated, and who used the SwissCovid app during the study period and got vaccinated during the study period. We found an increased uptake of the vaccine associated with SwissCovid app use (aHR, 1.51; 95% CI: 1.40–1.62 [CI-DFU]; aHR, 1.79; 95% CI: 1.62–1.99 [CSM]) or adherence to preventive measures (aHR, 1.44; 95% CI: 1.28–1.62 [CI-DFU]; aHR, 1.82; 95% CI: 1.52–2.18 [CSM]). Decreased SwissCovid uninstallation risk was observed for participants who received their first vaccine dose throughout the study period (aHR, 0.55; 95% CI: 0.38–0.81 [CI-DFU]; aHR, 0.45; 95% CI: 0.27–0.78 [CSM]).
Conclusion
In evolving pandemic contexts, these findings can assist public health authorities in designing evidence-based communication strategies to enable adoption of preventive measures and novel health technologies across all population groups.
To analyse the greenness change in Dehradun city over the last 5 years using Machine Learning
Authors: Tiwari Rudra
Published: January 2023

This research paper focuses on analyzing the change in greenness in the city of Dehradun over the last 5 years using machine learning techniques. The study utilizes the high-resolution imagery and information provided by the Sentinel-2 satellite, which is part of the European Space Agency's Copernicus program. The Sentinel-2 satellite is equipped with a multispectral imaging instrument that captures images in 13 different spectral bands, including visible and near-infrared bands that are useful for monitoring vegetation. The paper utilizes the Normalized Difference Vegetation Index (NDVI) to assess the health and productivity of vegetation in Dehradun over the last 5 years. Machine learning algorithms are applied to the NDVI data to analyze the greenness change in the city. The study provides insights on the temporal changes in the greenness of Dehradun and its impact on urban planning, regional development, and natural resource management.
Mapping endemic freshwater fish richness to identify high priority areas for conservation: an ecoregion approach
Authors: Yousefi Masoud , Jouladeh-Roudbar Arash , Kafash Anooshe
Published: January 2023

Freshwater ecosystems are among the most threatened ecosystems. Thus, knowing where these unique ecosystems’ species richness reaches a peak can facilitate their conservation planning. By hosting 289 freshwater fishes, Iran is a major freshwater fish hotspot in the Middle East. Considering the accelerating rate of biodiversity loss, there is an urgent need to identify species rich areas and understanding of the mechanisms driving biodiversity distribution. In this study, we gathered distribution records of all endemic freshwater fishes of Iran (85 species) to develop their richness map and determine the most critical driver of their richness pattern with an ecoregion approach. We performed a generalized linear model (GLM) with quasi-Poisson distribution to identify contemporary and historical determinants of endemic freshwater fish richness. We also quantified endemic fish similarity among the 15 freshwater ecoregions of Iran. Results showed that endemic freshwater fish richness is highest in the Zagros Mountains and moderate level of richness was observed between Zagros and Alborz Mountains. High, moderate and low richness of endemic freshwater fish match with Upper Tigris & Euphrates, Namak, and Kavir & Lut Deserts ecoregions respectively. Precipitation and precipitation change velocity since the Last Glacial Maximum were the most important predictor of freshwater fish richness. Areas identified to have the highest species richness have high priority for the conservation of freshwater fish in Iran, therefore, should be considered in future protected areas development.
PRAKTIK DOMINASI TOKOH ANTAGONIS MELALUI KEKERASAN SIMBOLIK DALAM FILM BETTER DAYS《少年的你》
Authors: Masrur Muhammad Farhan
Published: January 2023

When language is used in communication events, there also as an ideological distiction and a desire to dominate each other among its users. Because language is never separated from ideological motives, including domination motives. Domination occurs due to the existence of a strong group as the dominating party and a weak group as the dominated party with language as an instrument to achieve it. Symbolic violence marked by language forms that represent language crimes is a realization of the practice of domination. Through symbolic violence, the dominant party imposes its ideological influence on the dominant group. The practice of domination through symbolic violence can be found in the dialogue text of the antagonist in the film Better Days《少年的你》by Derek Tsang which is used as a data source. The patterned language forms used by the antagonist to attack the main character are used as data. After the data is identified and classified, it is analyzed through a qualitative approach using the concept of Bourdieu's theory of symbolic violence. The results of the analysis are presented through a descriptive method to obtain a detailed and concrete picture of the practice of domination of antagonist characters through symbolic violence. The results of the analysis show that symbolic violence, which represents the practice of domination, is realized through forms of language that have functioned as the language of punishment, the language of intimidation, the language of prohibition, the language of accusation, the language of insults, and language of command. Cultural capital (attitudes and lifestyles) is the most dominant capital that represents the attitudes and behavior of antagonists to produce and reproduce texts to legitimize their domination. Based on the frequency of occurrence, forbidden language is the most productive form of language, and accusation language is the language form with the least frequency of occurrence.
Terveyshistoria. Näkökulmia ja lähestymistapoja keskiajalta nykypäivään
Authors: Kananoja Kalle
Published: January 2023

Health History. Viewpoints and Approaches from the Middle Ages to the Present This book deals with approaches, sources, and methods in health history from the middle ages to the twentieth century. Individual chapters demonstrate how historians of medicine and health choose their methodological approaches and form interpretations from primary sources. They discuss the practices of writing and show how obstacles in the research process can be overcome. Practical examples of source materials, used methods and research challenges give tools to students for carrying out projects independently and help them to understand different possibilities in the field of health history. In this book, history of health includes but is not limited to medical science. Emphasising medical pluralism, it places (public) health in a cultural and social field encompassing official and unofficial practitioners, medical institutions, and patients. Individual case studies highlight themes in Finnish, European, and African history.
Pyhän Mechtildin ilmestykset
Authors: Kauko Mikko
Published: January 2023

Saint Mechthild’s Revelations Mechthild of Hackeborn represents medieval mysticism. Her Revelations were written down in the 1290s in Helfta, Germany. The oldest surviving versions are in Latin, but in the Middle Ages, the Revelations were translated at least into Dutch, English, Swedish, and German. The text was translated into Swedish in 1469 by Jöns Budde, a Bridgettine brother from Naantali. Budde made few omissions but many additions in the text, mainly explanations to meet the needs of the Bridgettine sisters. Budde’s translation is faithful to the original text, and he made few mistakes. My Finnish translation of the text follows Budde’s version where possible. However, Budde translated an abridged version that omitted some chapters, and the only surviving copy of Budde’s translation is incomplete. I have therefore translated the missing sections from Latin and incorporated them in the text. My translation also includes editorial comments on the language, the contents, and the historical and theological contexts of the Revelations.
ANALYSIS THE OUTCOME OF COVID POSITIVE DELIVERIES IN TERTIARY CARE HOSPITAL IN RURAL INDIA
Authors: Ghogare Shweta , Hol Kishorkumar
Published: January 2023

Aims And Objective:To evaluate the effect of coronavirus disease 2019(COVID19) on maternal perinatal and neonatal outcomes.The clinical characteristics and outcomes in pregnancy and the vertical transmission potential of SARS-COV-2 infection.
TENEURS EN NITRATES DANS LES AQUIFERES DISCONTINUS DU SOCLE DU DAMAGARAM MOUNIO (EST DU NIGER)
Authors:   Universite Andre Salifou (UAS), Faculte des Sciences et Techniques (FST), Departement des Sciences Geoloqiues et Environnementales (SGE), Zinder, Niger., Hamidou Abdou , Adede Ibrahim ,   Direction Regionale de lHydraulique et de lAssainissement de Zinder (DRHA/Z). Laboratoire de chimies des eaux de la Direction Regionale de lHydraulique et de lAssainissement, Zinder, Niger., Habou Issa ,   Direction Regionale de lHydraulique et de lAssainissement de Zinder (DRHA/Z). Laboratoire de chimies des eaux de la Direction Regionale de lHydraulique et de lAssainissement de Zinder, Niger.
Published: January 2023

The basement of Damagaram Mounio, study area, outcrops in the eastern part of the Zinder region. It is a very populated area and where the problem of water resources is acute. In addition to the low availability of this water resource, its quality remains questionable in several areas. Thus, the contents of certain chemical parameters, including nitrates in particular, greatly exceed the drinking water standards for human consumption, hence the present study, which has as its main objective, the determination of the percentages of boreholes whose the waters have nitrate levels above the WHOstandard. The methodological approach based on the sampling of hydraulic structures capturing the aquifers of the basement, the analysis of the physicochemical and isotopic parameters of the waters of several boreholes, the determination of the characteristics of the nitrates, made it possible to lead to several interesting results.Thus, the nitrate contents of the waters of the Damagaram Mounio basement aquifers vary from 0.22 to 313.3 mg/L, with an average of 72.23 mg/L, and a standard deviation of 62.23. This study made it possible to show that 32% of the modern structures sampled have nitrate levels above the admissible limit value for drinking water, set at 50 mg/L, according to the standards of the World Health Organization (WHO) these waters are unfit for human consumption. The spatial distribution of nitrate levels in groundwater in the area showed that these are more accentuated between the towns of Damagaram Takaya and Birni Kazoe, which are characterized by values â€‹â€‹above 100 mg/l. The relation between nitrate contents and water electrical conductivity values â€‹â€‹showed that the mineralization of groundwater in the area is controlled by nitrate ions. Furthermore, the isotopic levels of Nitrogen 15 (15N), obtained in the waters of the area, vary from 0 to 7.2, thus showing that these nitrates could come from the nature of the soil (quagmire around water points) and chemical fertilizers (ureas and fertilizers used in the study area).
CASE REPORT: TUBERCULOUS SCLERITIS A CHALLENGING DIAGNOSTIC
Authors:   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco., Ouail Hassimi , Soukaina Bouziane ,   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco., Ahmed Bennis ,   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco., Fouad Chraibi ,   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco., Meriem Abdellaoui ,   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco., Andaloussi Idriss Benatiya ,   Department of Ophthalmology, University Hospital Center Hassan II, Omar Drissi Hospital, Fez, Morocco.
Published: January 2023

Scleritis is a severe painful inflammatory process localized in the sclera. Scleritis may be the revealer of many systemic diseases so that it is important to exclude multisystem disease. We present a case of non-necrotizing antero-posterior scleritis revealing a systemic tuberculosis which is an uncommon manifestation of tuberculosis. Diagnosing and managing the disease can be difficult. However, a good anamnesis, a careful clinical evaluation, an adequate interpretation of the investigations and an appropriate management allow a good prognosis.
PREVALENCE, DIAMETER AND FURRING OF MANDIBULAR INCISIVE CANAL IN NORTH INDIAN SUBPOPULATION: A CBCT STUDY
Authors:   Post Graduate Student, Departmentof Conservative Dentistry and Endodontics Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India., Rohilla Smriti , Negi Shabnam ,   Reader, Departmentof Conservative Dentistry and Endodontics Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India., Makkar Sameer ,   Professor and Head, Department of Conservative Dentistry and Endodontics Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India., Garg Nisha ,   Professor, Department of Conservative Dentistry and Endodontics, Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India., Gupta Sandeep ,   Reader, Department of Conservative Dentistry and Endodontics Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India., Sikri Jyotsana ,   Reader, Department of Conservative Dentistry and Endodontics Bhojia Dental College and Hospital, Baddi, Himachal Pradesh, India.
Published: January 2023

Objective: The Mandibular Incisive Canal (MIC) carries mandibular neurovascular bundle and it is necessary to determine the presence of MIC & its relation to adjacent anatomical landmarks to avoid any potential damage to neurovascular bundle during various surgical procedures. So, this study was planned to determine the prevalence, canal diameter and its relation with adjacent anatomic structures using CBCT and to find their associations with age, gender and laterality. Methods: CBCT scans of 61 patients (33 M, 28 F) were evaluated in sagittal sections. Results: The overall prevalence of MIC on the right side was found to be 65.6% while it was 73.8% on the left side. The MIC was more prevalent in females as compared to males between the 30-50 years of age. The mean diameter on the right and left side was found to be 0.85 Â± 0.25 mm & 0.93 Â± 0.27 mm respectively. The mean distance of MIC from buccal cortex was (3.5 Â± 1.3 & 3.6 Â± 1.8 mm), lingual cortex (4.8 Â± 1.6 & 4.8Â± 2.0 mm) & inferior border of the mandible (10.1 Â± 3.7 &10.4 Â± 3.3 mm) on right and left side respectively. Conclusions: The preoperative assessment of CBCT is advocated especially in middle age, females and left side for MIC evaluation &the findings of this study will help in identifying safe area during surgical procedures in inter-foraminal region. Periapical surgery, implants, genioplasty etc. can be planned in a better manner by avoiding potential danger areas.
PUBLIC SPACE AND MONUMENTAL ARCHITECTURE
Authors:   Associate Professor, Faculty Of Architecture, Research Center of Territory, Architecture and Design, Lusiada University., Patricia D. , Teresa P. ,   Auxiliar Professor, Faculty Of Architecture, Research Center of Territory, Architecture and DesignLusiada University.
Published: January 2023

The Belem Tower was initiated in 1515, thus being built the last fortress, a military defence mechanism strategically placed on Tagus, but it also served as a protection to the biggest monastery built, the Monastery and Church of Jeronimos. Paulo Pereira emphasises that this reason explains the morphology of the Tower and its ornamental opulence, which both accorded with current taste and was suited to its location on the bank of the river.
A SYSTEMATIC REVIEW OF SOFTWARE AND RESOURCES AVAILABLE IN THE PHARMACEUTICAL SECTOR
Authors:   Department of Pharmacy Practice, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Kalaivani R. , Muthu P. ,   Bachelor of Pharmacy, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Nelavanbu M. ,   Bachelor of Pharmacy, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Sathyamoorthi R. ,   Bachelor of Pharmacy, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Kasi Viswanathan S. ,   Bachelor of Pharmacy, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India., Rajamohamed H. ,   Department of Pharmacy Practice, Thanthai Roever College of Pharmacy (affiliated with The Tamil Nadu Dr.M.G.R Medical University), Perambalur, Tamil Nadu, India.
Published: January 2023

The whole pharmaceutical area (pharmacy industry, pharmacy billing, clinical trials, pharmacovigilance, and drug-drug interaction detection) needed various innovative and scientific solutions to solve the problems. A systematic review was performed on various software applications widely used in the pharmaceutical industry, including clinical trials, pharmacy billing, pharmacovigilance, the detection of drug interactions that assist the healthcare professional. Our review concluded that computer software has created a significant role in the pharmaceutical industry, pharmacy billing, and herbal industry. The computer software and programmes aid in reducing manufacturing costs, manufacturing errors, medical errors, and clinical errors.The software performs various safety functions, supplies on-screen access to pertinent drug and patient information, manages data, and assists in the product formulation process. The programmed safeguards can be modified to meet changing requirements.
A SINGLE-CENTER CROSS-SECTIONAL STUDY OF SEROPREVALENCE OF HEPATITIS B AND C IN MOGADISHU, SOMALIA
Authors:   Department of Infection ControlKalkaal Hospital, Mogadishu, Somalia., Abdullahi Hassa Sakariye , Abdullahi Mohammed Suleyman ,   Senior Consultant GI-Surgery Kalkaal Hospital, Mogadishu, Somalia., Kimutai Timothy ,   Statistics and InformationKalkaal Hospital, Mogadishu, Somalia.
Published: January 2023

Introduction: Chronic viral hepatitis continues to be a global problem responsible for significant morbidity and death and a substantial economic burden. The World Health Organization estimated 296 million and 58 million individuals to be infected with HBV and HCV in 2019. In Somalia, few studies reported on HBV and HCV have shown varying results. This study is conducted to give insights on prevalence in Somalia. Methods: This cross-sectional study was conducted on data collated from June 2019 to July 2022 among patients visiting Kalkaal Hospital, Mogadishu, Somalia. The Kolmogorov-Smirnov test was used to determine the datas normality, and the Chi-square test to determine the difference between categorical variables. A total of 24,017 people were included in the study, comprising 58.4% females and 41.6% men. The prevalence of hepatitis B was 4.2%, while the prevalence of hepatitis C was 0.3%. The HBV prevalence was highest among females aged 50 to 59 (10.1%). HCV prevalence was highest among males aged over 60(3.6%). Conclusion:The high prevalence of HBV and HCV across genders and its variation for different age groups in this study highlights a severe public health issue that requires rethinking vaccination strategy and policy.
BIO-ORGANIC FERMENTATION IMPROVED THE MORPHOPHENOTYPIC AND ECONOMIC ANALYSIS OF LETTUCE (LACTUCA SATIVA VAR. RED RAPID)
Authors:   College of Agriculture, Food Science, Business and Communication., D. Tangpos Marciano ,   Cebu Technological University Barili Campus.,   CagayBarili Cebu, Philippines.
Published: January 2023

This study was conducted to determine the effectivity of different organic concoctions for organically grown lettuce in a hydroponic system in one season only from 2020-2021. The organic material includes Fish Amino Acid, Fermented fruit Juice, Fermented Plant Juice, Indigenous Microorganism II, and Fermented Golden Apple Snail. Two tablespoons per liter of each organic concoction were added and applied at biweekly intervals. All treatments were in triplicate arranged in a complete randomized design and statistically analyzed with Duncans Multiple Range Test using STAR. The effect of FAA, FFJ, FPJ, IMO II, OHN, and GAS significantly had higher plant heights and leaf numbers. However, FFJ and GAS markedly higher shot weight, shoot-root ratio, and lesser root-shoot ratio, including the FPJ. Meanwhile, FFJ and GAS consistently had higher above-ground biomass, gross income, yield efficiency, income efficiency, and equilateral efficiency. All organic concoctions showed the potential to produce higher economic yield. However, the application of FFJ and GAS outstands yield and economic indicators compared to other organic concoctions, as reflected in the study.
ASPECTS OF WELL-BEING AND ACADEMIC ACHIEVEMENT OF COLLEGE STUDENTS DURING COVID-19
Authors:   Department of Digital Learning, SGT University, Budhera, Gurugram-Badli Road, Gurugram 122505, Haryana, India., C. Joshi Suresh , Aggarwal Dhruv ,   Jindal School of Psychology and Counselling, O.P. Jindal Global University, Sonipat, Haryana, 131001, India., Sejwal Sonali ,   Jindal School of Psychology and Counselling, O.P. Jindal Global University, Sonipat, Haryana, 131001, India., Gupta Vrinda ,   Jindal School of Psychology and Counselling, O.P. Jindal Global University, Sonipat, Haryana, 131001, India.
Published: January 2023

This article primarily focused on presenting a narrative review of the literature describing the aspects of the well-being of college students during the COVID-19 pandemic. Physical, emotional, social, and cognitive aspects of well-being were presented using various examples of the challenges faced by college students during COVID-19. The article further focused on highlighting the challenges faced by college students in fulfilling their academic goals during COVID-19. Implications of the outcomes were discussed with the potential recommendations for future research.
SEVERE HYPERTRIGLYCERIDEMIA IN CONGENITAL GENERALIZED LIPODYSTROPHY: A CASE REPORT
Authors:   Laboratoire de Biochimie Clinique, Centre Hospitalier Universitaire Mohammed VI, Marrakech. Faculte de Medecine et Pharmacie, Universite Cadi Ayyad, Marrakech, Maroc., Aboulmakarim Siham , Zahlane Kaoutar ,   Laboratoire danalyses medicales, HÃ´pital Ibn Tofail, Centre Hospitalier Universitaire Mohammed VI, Faculte de Medecine et Pharmacie, Universite Cadi Ayyad, Marrakech, Maroc.
Published: January 2023

Lipodystrophic syndromes represent a heterogeneous group of very rare diseases inherited or acquired, characterized by altered body fat amount and/or repartition and metabolic alterations including marked insulin resistance and dyslipidemias. We report the case of severe hypertriglyceridemia at 96 g/L in 28-year-old Moroccan women admitted for decompensated diabetes mellitus and generalized lipodystrophy. This case illustrates the value of hypertriglyceridemia in the diagnosis and monitoring of lipodystrophic syndromes whose diagnosis is made by clinical assessment and laboratory findings.
UNDERSTANDING TRANSGENDER PEOPLE (HIJRA) IDENTIFICATION AND EMPOWERMENT STATUS IN BANGLADESH
Authors: Mawa Jannatul
Published: January 2023

This research aims to explore the factors that suppress the empowerment of transgender people in Bangladesh and will examine how Bangladesh can ensure gender equality through the empowerment of transgender people. Additionally, it will help to provide some recommendations to amend the gender policy strategies of the country.
SYNTHESIS AND CHARACTERIZATION NOVEL EMERALDINE-SALT@PORANGCOMPOSITES THIN FILM:CONDUCTIVITY STUDIES
Authors:   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., a Busroni , Prasanty Arum ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Wicaksono Anggoro ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Irfan Efendi Moh ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Aullia Intan Mawarni Safna ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Hidayat Bambang ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Nalita Devi ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Piluharto Bambang ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Indarti Dwi ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Jember University Jl. Kalimantan 37, Jember 681752., Anwar Chairil ,   Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Gadjah Mada University Jl. Sekip Utara, Yogyakartan 55281.
Published: January 2023

A synthesis of the emeraldine salt@porangcomposite was synthesized using the in situ chemical polymerization method to form the ES@Porang composite. Polymerization using ammonium peroxodisulphate as an initiator in the aniline oxidative polymerization process and using H2SO4 doping. The composite films were prepared with variations in dopant concentration and variations in the amount of glucomannan. Characterization of the ES@Porang composite using FTIR and conductivity testing using an LCR-meter. The optimum conductivity values â€‹â€‹of the ES@Porangcomposite thin film with variations in dopant concentration and amount of glucomannan were 24.3 x 10-3, 58.2 x 10-3, and 84,3 x 10-3 S/cm respectively.
TUMEURS GRELIQUES QUELLES DIVERSITES HISTOLOGIQUE ?
Authors:   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Driouiche S. , Mernissi A. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Attar A. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Lahlali M. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Lamine A. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Lahmidani N. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Elmekkoui A. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Elyoussfi M. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Benajah D. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Labkari M.E ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Ibrahimi A. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc., Abid H. ,   Service dHepato-Gastroenterologie, CHU HASSAN II, Fes ,Maroc.
Published: January 2023

Primary malignant tumors of the small intestine are rare tumors. They represent 1 to 5% of all tumors of the digestive tract. The multiplicity of histological types associated with the rarity of these tumors. The small intestine is considered as a clinically silent area and this results in a delay in diagnosis and therefore a non-optimal treatment and a severe prognosis. The objective of our work is to report the epidemiological, diagnostic characteristics of patients with small bowel tumors as well as their endoscopic and histological aspects collected in the hepato-gastroenterology department of the Hassan II University Hospital of Fez. Patient and method:We retrospectively analyzed the clinical records of 8 patients with the diagnosis of small bowel malignancies admitted to our training over a period of 11 years. Results: The average age of our patients was 42 years,The sex ratio M/F was 3, the tumor was revealed by an upper GI hemorrhage in 50%(N: 4) followed by abdominal pain in 37%(N: 3) and koening syndrome in 12%(N: 1). The CT scan showed a parietal thickening in all the cases, of which 1 case showed a mass. Double balloon enteroscopy was performed in 8 patients (100%), the endoscopic aspect revealed an ulcerating process in 75% (N: 6), a tumor of sub-mucosal appearance in 12% (N: 1). An ulcerated jejunal stenosis that could not be crossed in 12% (N:1).the biopsy by enteroscopy had allowed to make the diagnosis in 100% of the cases (N: 8).the histological examination had objectified: lymphomas in 37%( N: 3), GIST in 25% cases (N: 2), adenocarcinomas in 25% cases (N: 2) and neuroendocrine tumor in 12% (N: 1). The evolution was unfavorable in all our cases with a median survival rate of 10 months. Conclusion: Small bowel tumors are rare but interesting because of their great histological diversity. The diagnosis is difficult because of the non-specific symptomatology, In our study the couple imaging -enteroscopy had allowed to establish the diagnosis in all our cases, with predominance of the anatomopathological aspect of lymphoma in 37% of the cases.
SUICIDAL INGESTION OF MASSIVE COLCHICINE OVERDOSE WITH RECOVERY
Authors:   Departmet of Internal Medicine, ArAr Central Hospital, ArAr, Northern Region, Kingdom of Saudi Arabia., Khan Abullah , Altaf Nusrat ,   Departmet of Internal Medicine, ArAr Central Hospital, ArAr, Northern Region, Kingdom of Saudi Arabia., Zainab Nisma ,   Departmet of Internal Medicine, ArAr Central Hospital, ArAr, Northern Region, Kingdom of Saudi Arabia., Sani Abdullah ,   Departmet of Internal Medicine, ArAr Central Hospital, ArAr, Northern Region, Kingdom of Saudi Arabia., Aljasir Saud ,   Departmet of Internal Medicine, ArAr Central Hospital, ArAr, Northern Region, Kingdom of Saudi Arabia.
Published: January 2023

Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multiple organ failure, whether directly from colchicine toxicity or due to ensuing sepsis. We report an extreme case of colchicine ingestion (200 tablets, 0.5 mg ,1.6mg/kg) which is the largest reported non fatal colchicine overdose.Early implementation of a targeted therapeutic plan directed at the predicted multi organ failure which included aggressive use of activated charcoal, timely supportive measures including broad spectrum antibiotics and G-CSF for sepsis, ventilatory support, renal replacement therapy as well as as transfusion of blood and blood products resulted in complete recovery and discharge of the of patient off dialysis.
Sin mujeres no hay democracia: mujeres indígenas y los procesos de consulta previa en el Perú
Authors: De La Cruz Huamán Rosario Betzabeth
Published: January 2023

El presente artículo analiza la participación de las mujeres indígenas en el Perú, específicamente en los procesos de consulta previa. Cabe indicar que este es un derecho específico de los pueblos indígenas reconocidos en el marco normativo internacional y nacional, que tiene como principal fin establecer acuerdos con el Estado ante cualquier medida de carácter legislativo o administrativo que afecte los derechos colectivos de estos pueblos. A pesar de ello, se advierte una serie de dificultades generales en su aplicación y particulares en lo que se refiere a la participación de las mujeres indígenas, quienes experimentan múltiples brechas de desigualdad que afectan su desarrollo. Igualmente, estas barreras constituyen una vulneración al principio de igualdad y no discriminación así como obstruyen el camino de edificar un Estado con una actuación democrática que contribuya a la interculturalidad y a la igualdad de género.
Development and Optimization of Guggal Extract Loaded Ultradeformable
Vesicles using Central Composite Design for Improving Antioxidant
Potential
Authors: Mittal Vineet , Dhankar Neha , Verma Ravinder , Kumar Manish , Hooda Anil , Kaushik Deepak
Published: January 2023

Background:

After almost 30 years of study, it is a scientific fact that inflammation is the
root cause of arthritis.

Objective:

Guggul has a beneficial role in arthritis because of its ability to neutralize the NF-kappa
factor. A topical drug delivery system is beneficial to overcome the problems associated with oral
drug delivery and offers several potential advantages. Ultra-deformable vesicles (UDVs) are a special
type of liposome made up of phospholipids and surfactants, and they are highly flexible.

Methods:

In the present investigation, 20 formulations were suggested by Design Expert® 10 software
(Central Composite Design) which were prepared using film hydration method with lecithin (70-90
mg), tween 80 (10–30 mg), Guggul extract (3 mg) and sonicated for 5–15 minutes. The formulation
was optimized based on particle size (R₁) and maximum entrapment efficiency (R2).

Results:

The optimized formulation consists of 78.92 mg soya phosphatidyl choline (lecithin), 22.08
mg Tween 80, and 3 mg Guggul with a sonication time of 12.74 minutes that resulted in a particle size
of 375.5 ±15.1 nm and entrapment efficiency of 80.3 ± 3.1%. Guggul UDVs showed more antioxidant
activity compared to Guggul extract, control and standard. Similar results were obtained in the case of
anti-arthritic activity, which was measured by egg albumin denaturation, bovine serum albumin denaturation,
proteinase inhibitory action, and anti-lipoxygenase activity. The data of both activities were
analyzed using an unpaired t-test to determine significant values (p < 0.05).

Conclusion:

These results demonstrate the potential of UDVs in the treatment of all arthritis diseases.
Mechanistic Study on the Possible Role of Embelin in Treating Neurodegenerative Disorders
Authors: Anika  , Arora Rimpi , Virendra Sharma A. , Chawla Pooja A.
Published: January 2023

Embelin (EMB) (2,5-Dihydroxy-3-undecyl-1,4-benzoquinone) is a natural benzoquinone extracted mainly from Embelia ribes (ER) and appear as vivid orange dots beneath the fruit's pericarp. It is being used to treat various diseases since ancient times in India. It has been ascribed as one of the 32 ayurvedic drugs of national importance in the National Medicinal Plant Board set up by the Government of India under the Ministry of Indian System of Medicine and Homeopathy. Embelin prevents neuronal oxidative damage by decreasing the peroxidation of lipids. Along with having antioxidant properties, it also prevents the production of amyloid-protein-related fibrils and blocks the progression of inflammatory cascades. Due to embelin's ability to cross the blood-brain barrier, its neuroprotective effects have been studied in the past using in vitro models of neuronal disorders such as convulsion and epilepsy, Alzheimer's disease, anxiety and depression, traumatic brain injury, cerebral ischemia, Huntington's disease, and multiple sclerosis. In addition to its neuroprotective effects, its role as an antitubercular, anti-cancer, antioxidant, astringent, anti-inflammatory, anti-bacterial, contraceptive, carminative, diuretic, and anthelmintic agent has also been studied. With docking studies and recent advancements in formulations of embelin including polyethylene and embelin micelles and embelin noisome preparations, embelin can prove to be a promising compound for its therapeutic actions in a wide range of diseases and disorders. The findings of docking studies suggest the binding ability of embelin to be similar to the standard drug in their respective disorders. In this review and docking analysis, we bring an outline of scientific evidence concerning the neuroprotective actions of embelin, still, further research is required for its prospective as a chief compound in clinical approaches.
Current State of Application of Formal Thought Disorder
Screening Methods in First-Degree Relatives of Patients With
Schizophrenia: A Narrative Review
Authors: Völker Jes Sebastian , Micluția Ioana Valentina , Hanga Adela-Melania
Published: January 2023

Historically, formal thought disorder (FTD) has been considered one of the distinctive
key symptoms of schizophrenia and is still regarded as an important early warning sign
and a marker of illness severity with solid predictive value. Recent studies are able to found
that the presence of FTD is predictive of the subsequent diagnosis of schizophrenia and often
precedes the frank clinical picture by several months. Much effort has been put into developing
scales that can reliably detect FTD and can be readily applied in routine clinical practice. This
narrative review investigated the use of FTD as a screening tool to assess risk in first-degree
relatives of patients with schizophrenia. The results show that the use of these scales in firstdegree
relatives of schizophrenic individuals during clinical contact and counseling is still an
exception, despite their uniquely heightened vulnerability profile. To our knowledge, this is the
first time that the application of FTD screening methods in first-degree relatives of schizophrenic
individuals has been reviewed in a structured way.
Implementing Sukuk Financing in Indonesia: Policy Actions to Improve and Support Development Research and Development Infrastructure (RDI)
Authors: Putera Prakoso Bhairawa , Widianingsih Ida , Rianto Yan , Ningrum Sinta , Suryanto Suryanto
Published: January 2023

The Indonesian government realizes that developing alternative instruments for financing the state budget needs to continue—one of them with financing instruments based on sharia principles. This study examines the response of the Indonesian government in policy actions to seek financing for research and development infrastructure through Sukuk financing. This study uses a qualitative method with a narrative approach. This study uses three data collection techniques: regulatory survey, secondary data research, and Expert Elicitation with Experts' Judgments. Meanwhile, the data analysis technique uses content analysis, stakeholder analysis matrix, 're-analysis,' and digital discourse analysis. The results of this research reveal that the policy actions taken by the Indonesian government are through 1) regulatory in the form of policies related to the Sukuk financing policy in Indonesia, by issuing one regulation in the form of a law, one rule in the form of a Government Regulation of the Republic of Indonesia, and four rules at the level of ministerial regulations. On the other hand, the results of the mapping of stakeholders show that there are four clusters of actors, namely decision makers, project initiators, support partners, and civil society - media. 2) applicative action in the form of budget allocation related to infrastructure financing Sukuk in the research and development sector, during 2018-2022, financed 41 projects from 10 ministries/agencies. In the end, this research provides recommendations; namely, it is necessary to diversify the types of infrastructure that can be financed from Sukuk financing so that they follow the needs of Ministries/Agencies and Local Governments.
Pd-Ni-B/C Nanocatalysts for Electrochemical Oxidation of Ethanol in Alkaline Media
Authors: Ribeiro Jamylle , Silva Ronaldo , Salazar-Banda Giancarlo , Eguiluz Katlin
Published: January 2023

This paper describes the synthesis of Pd0.70-Nix-By nanoparticles (x:y = 0.30:0, 0:0.30, 0.25:0.05, 0.20:0.10, 0.15:0.15, and 0.10:0.20) supported on carbon Vulcan XC-72 R by the chemical reduction method using ethylene glycol as a reducing agent for the study of the electrochemical oxidation of ethanol in alkaline media. Neither surfactants nor templates were used during the syntheses. The catalysts were physically characterized by transmission electron microscopy that showed the formation of nanoparticles with diameters of approximately 3 nm. Analyses of X-ray dispersive energy spectroscopy coupled with scanning electron microscopy identified the presence of the synthesized metals in concentrations close to the nominal ones. The electrochemical study was performed by CO-stripping, cyclic voltammetry, chronoamperometry, and steady-state polarization curves. The catalytic efficiency was also evaluated against the oxidation of CO, which is the principal intermediate adsorbed on the surface of catalysts during ethanol oxidation. The Pd0.70Ni0.15B0.15/C catalyst showed the lowest oxidation onset potentials for both CO (0.37 V) and ethanol oxidation (0.51 V) compared with the Pd/C catalyst (0.63 V and 0.64 V). Chronoamperometric tests also revealed that the Pd0.70Ni0.15B0.15/C catalyst displayed current densities four times higher than those of the Pd/C catalyst, probably because of the electronic and geometric effect that favors the removal of intermediate species from the catalyst surface. The synthesized ternary catalysts were more efficient toward the electrochemical oxidation of ethanol in alkaline media than Pd0.7Ni0.3/C and Pd/C catalysts. Thus, the synergistic effect of boron on the structure of binary nanoparticle catalysts supported on carbon for use in direct alcohol fuel cells was demonstrated for the first time.