bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity
Authors: Chen Cheng-Yu , Chen Chien-Chang , Wang Chen-Ying , Lee Alvin Kai-Xing , Yeh Chun-Liang , Lin Chun-Pin
Published: June 2020

Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Therefore, we drafted a plan to accelerate bone regeneration via VEGF released from the hydroxyapatite/calcium sulfate (HACS) scaffold. Herein, HACS will gradually degrade and provide a suitable environment for cell growth and differentiation. In addition, HACS scaffolds have higher mechanical properties and drug release compared with HA scaffolds. The drug release profile of the VEGF-loaded scaffolds showed that VEGF could be loaded and released in a stable manner. Furthermore, initial results showed that VEGF-loaded scaffolds could significantly enhance the proliferation of human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVEC). In addition, angiogenic- and osteogenic-related proteins were substantially increased in the HACS/VEGF group. Moreover, in vivo results revealed that HACS/VEGF improved the regeneration of the rabbit’s femur bone defect, and VEGF loading improved bone tissue regeneration and remineralization after implantation for 8 weeks. All these results strongly imply that the strategy of VEGF loading onto scaffolds could be a potential candidate for future bone tissue engineering.
l-Arginine Grafted Poly(Glycerol Sebacate) Materials: An Antimicrobial Material for Wound Dressing
Authors: Wang Chia-Chun , Shih Ting-Yu , Hsieh Yi-Ting , Huang Jie-Len , Wang Jane
Published: June 2020

This study focuses on the development and evaluation of a novel wound dressing material. l-arginine grafted poly(glycerol sebacate) materials (PGS-g-Arg) are developed by chemical conjugation of l-arginine on poly(glycerol sebacate) chains and the mechanical property, water vapor transmission rate, antimicrobial functions and biocompatibility are investigated. At various l-arginine grafting ratio, the mechanical properties are tunable. It was found that between 7–13% l-arginine grafting ratios, the tensile strengths of PGS-g-Arg were similar to that of natural skin. These materials are shown with a low water vapor transmission rate, 6.1 to 10.3 g/m2/h, which may form a barrier and assist in the closure of wounds. Inhibition in the growth of Pseudomonas aeruginosa and Staphylococcus aureus was observed on PGS-g-Arg, and a series of experiments were conducted to confirm its biocompatibility. In summary, l -arginine grafted poly(glycerol sebacate) may offer a novel option for wound dressing.
Interpolymer Complexes of Eudragit® Copolymers as Novel Carriers for Colon-Specific Drug Delivery
Authors: Bukhovets Aleksandra V. , Fotaki Nikoletta , Khutoryanskiy Vitaliy V. , Moustafine Rouslan I.
Published: June 2020

Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v) and tetrahydrofuran). According to the data of elemental analysis, FTIR-spectroscopy, X-ray photoelectron spectroscopy and thermal analysis these IPCs have excess of anionic copolymer (Eudragit® S100) in their structure; they are stabilized by hydrogen and ionic intermacromolecular bonds and do not include free copolymer domains. IPC have pH-independent swelling properties in the media mimicking gastrointestinal tract (GIT) conditions and provide colon-specific delivery of indomethacin in buffer solutions (pH 1.2; 5.8; 6.8; 7.4) and in biorelevant media (fasted state simulated gastric fluid, fasted state simulated intestinal fluid—version 2 and fasted stated simulated colonic fluid).
Anti-Bacterial and Anti-Fouling Capabilities of Poly(3,4-Ethylenedioxythiophene) Derivative Nanohybrid Coatings on SUS316L Stainless Steel by Electrochemical Polymerization
Authors: Hsu Chuan-Chih , Cheng Yu-Wei , Liu Che-Chun , Peng Xin-Yao , Yung Ming-Chi , Liu Ting-Yu
Published: June 2020

We have successfully fabricated poly(3,4-ethylenedioxythiophene) (PEDOT) derivative nanohybrid coatings on flexible SUS316L stainless steel by electrochemical polymerization, which can offer anti-fouling and anti-bacterial capabilities. PEDOT derivative nanohybrids were prepared from polystyrene sulfonates (PSS) and graphene oxide (GO) incorporated into a conducting polymer of PEDOT. Additionally, the negative charge of the PEDOT/GO substrate was further modified by poly-diallyldimethylammonium chloride (PDDA) to form a positively charged surface. These PEDOT derivative nanohybrid coatings could provide a straightforward means of controlling the surface energy, roughness, and charges with the addition of various derivatives in the electrochemical polymerization and electrostatically absorbed process. The characteristics of the PEDOT derivative nanohybrid coatings were evaluated by Raman spectroscopy, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle, and surface potential (zeta potential). The results show that PEDOT/PSS and PEDOT/GO nanohybrid coatings exhibit excellent anti-fouling capability. Only 0.1% of bacteria can be adhered on the surface due to the lower surface roughness and negative charge surface by PEDOT/PSS and PEDOT/GO modification. Furthermore, the anti-bacterial capability (7 mm of inhibition zone) was observed after adding PDDA on the PEDOT/GO substrates, suggesting that the positive charge of the PEDOT/GO/PDDA substrate can effectively kill bacteria (Staphylococcus aureus). Given their anti-fouling and anti-bacterial capabilities, PEDOT derivative nanohybrid coatings have the potential to be applied to biomedical devices such as cardiovascular stents and surgical apparatus.
The Role of Reduced Graphene Oxide in the Suspension Polymerization of Styrene and Its Effect on the Morphology and Thermal Properties of the Polystyrene/rGO Nanocomposites
Authors: Sieradzka Marta , Fabia Janusz , Biniaś Dorota , Fryczkowski Ryszard , Janicki Jarosław
Published: June 2020

Reduced graphene oxide (rGO) was used to obtain Polystyrene (PS)/rGO nanocomposites via in-situ suspension polymerization. The main goal of the article was to determine how rGO influences the morphology and thermal properties of PS beads. The obtained samples were studied by means of a scanning electron microscope (SEM), and calorimetric and thermogravimetric analysis (DCS, TGA). It was proven that the addition of rGO, due to the presence of polar functional groups, causes significant changes in bead sizes and size distribution, and in their morphology (on the surface and in cross-section). The increasing amount of rGO in the polymer matrix increased the size of beads from 0.36 to 3.17 mm for pure PS and PS with 0.2 wt% rGO content, respectively. PS/rGO nanocomposites are characterized by distinctly improved thermostability, which is primarily expressed in the increase in their decomposition temperature. For a sample containing 0.3 wt% rGO, the difference is more than 12 °C in comparison to pure PS beads.
Polymethyl Methacrylate-Based Bone Cements Containing Carbon Nanotubes and Graphene Oxide: An Overview of Physical, Mechanical, and Biological Properties
Authors: Soleymani Eil Bakhtiari Sanaz , Bakhsheshi-Rad Hamid Reza , Karbasi Saeed , Tavakoli Mohamadreza , Razzaghi Mahmood , Ismail Ahmad Fauzi , RamaKrishna Seeram , Berto Filippo
Published: June 2020

Every year, millions of people in the world get bone diseases and need orthopedic surgery as one of the most important treatments. Owing to their superior properties, such as acceptable biocompatibility and providing great primary bone fixation with the implant, polymethyl methacrylate (PMMA)-based bone cements (BCs) are among the essential materials as fixation implants in different orthopedic and trauma surgeries. On the other hand, these BCs have some disadvantages, including Lack of bone formation and bioactivity, and low mechanical properties, which can lead to bone cement (BC) failure. Hence, plenty of studies have been concentrating on eliminating BC failures by using different kinds of ceramics and polymers for reinforcement and also by producing composite materials. This review article aims to evaluate mechanical properties, self-setting characteristics, biocompatibility, and bioactivity of the PMMA-based BCs composites containing carbon nanotubes (CNTs), graphene oxide (GO), and carbon-based compounds. In the present study, we compared the effects of CNTs and GO as reinforcement agents in the PMMA-based BCs. Upcoming study on the PMMA-based BCs should concentrate on trialing combinations of these carbon-based reinforcing agents as this might improve beneficial characteristics.
Polymer Brush Coating and Adhesion Technology at Scale
Authors: Buhl Kristian Birk , Agergaard Asger Holm , Lillethorup Mie , Nikolajsen Jakob Pagh , Pedersen Steen Uttrup , Daasbjerg Kim
Published: June 2020

Creating strong joints between dissimilar materials for high-performance hybrid products places high demands on modern adhesives. Traditionally, adhesion relies on the compatibility between surfaces, often requiring the use of primers and thick bonding layers to achieve stable joints. The coatings of polymer brushes enable the compatibilization of material surfaces through precise control over surface chemistry, facilitating strong adhesion through a nanometer-thin layer. Here, we give a detailed account of our research on adhesion promoted by polymer brushes along with examples from industrial applications. We discuss two fundamentally different adhesive mechanisms of polymer brushes, namely (1) physical bonding via entanglement and (2) chemical bonding. The former mechanism is demonstrated by e.g., the strong bonding between poly(methyl methacrylate) (PMMA) brush coated stainless steel and bulk PMMA, while the latter is shown by e.g., the improved adhesion between silicone and titanium substrates, functionalized by a hydrosilane-modified poly(hydroxyethyl methacrylate) (PHEMA) brush. This review establishes that the clever design of polymer brushes can facilitate strong bonding between metals and various polymer materials or compatibilize fillers or nanoparticles with otherwise incompatible polymeric matrices. To realize the full potential of polymer brush functionalized materials, we discuss the progress in the synthesis of polymer brushes under ambient and scalable industrial conditions, and present recent developments in atom transfer radical polymerization for the large-scale production of brush-modified materials.
Designing the Next Generation of Fe0-Based Filters for Decentralized Safe Drinking Water Treatment: A Conceptual Framework
Authors: Yang Huichen , Hu Rui , Ndé-Tchoupé Arnaud Igor , Gwenzi Willis , Ruppert Hans , Noubactep Chicgoua
Published: June 2020

The ambitious United Nations Sustainable Development Goal for 2030 to “leave no one behind” concerning safe drinking water calls for the development of universally applicable and affordable decentralized treatment systems to provide safe drinking water. Published results suggest that well-designed biological sand filters (BSFs) amended with metallic iron (Fe0-BSFs) have the potential to achieve this goal. Fe0-BSFs quantitatively remove pathogens and a myriad of chemical pollutants. The available data were achieved under various operating conditions. A comparison of independent research results is almost impossible, especially because the used Fe0 materials are not characterized for their intrinsic reactivity. This communication summarizes the state-of-the-art knowledge on designing Fe0-BSFs for households and small communities. The results show that significant research progress has been made on Fe0-BSFs. However, well-designed laboratory and field experiments are required to improve the available knowledge in order to develop the next generation of adaptable and scalable designs of Fe0-BSFs in only two years. Tools to alleviate the permeability loss, the preferential flow, and the use of exhausted filters are presented.
Influence of Electrostatic Interactions During the Resorcinol-Formaldehyde Polymerization on the Characteristics of Mo-Doped Carbon Gels
Authors: Morales-Torres Sergio , Jirglová Hana , Pastrana-Martínez Luisa M. , Maldonado-Hódar Francisco J.
Published: June 2020

The resorcinol (R)-formaldehyde (F) polymerization was carried out in different experimental conditions to obtain RF/Mo doped carbon xerogels with different morphology, porosity and nature and dispersion of metal. Attractive or repulsive electrostatic interactions were forced in the starting aqueous solution of RF-monomers using different synthesis conditions, namely, combinations of cationic or anionic surfactants, Mo-precursors and pH values. The results showed that when both cationic surfactant and Mo-precursor were used at neutral pH, attractive interactions with the anionic RF-macromolecules are favored during polymerization and the final carbon xerogel exhibited the most developed porosity and the strongest Mo-organic phase interaction, leading to deeper Mo-phase reduction during carbonization and the formation of highly-dispersed crystalline nanoparticles of Mo2C. On the contrary, the use of both anionic surfactant and Mo-precursor leads to repulsive interactions, which generates less porous carbon gels with a Mo-phase formed by large MoO3 platelet structures and low Mo-surface contents. RF/Mo-doped gels with intermediate properties were obtained by combining cationic and anionic surfactants, metal precursors or both. After carbonization, the obtained materials would be suitable to be used directly as catalysts with different physicochemical properties and active phases.
Geological Risk Calculation through Probability of Success (PoS), Applied to Radioactive Waste Disposal in Deep Wells: A Conceptual Study in the Pre-Neogene Basement in the Northern Croatia
Authors: Malvić Tomislav , Pimenta Dinis Maria Alzira , Velić Josipa , Sremac Jasenka , Ivšinović Josip , Bošnjak Marija , Barudžija Uroš , Veinović Želimir , Sousa Hélder Fernando Pedrosa e
Published: June 2020

The basic principles of geological risk calculation through probability of success (PoS) are mostly applied to numerical estimation of additional hydrocarbon existence in proven reservoirs or potential hydrocarbon discoveries in selected geological regional subsurface volumes. It can be adapted and validated for a comprehensive input dataset collected in the selected petroleum province, by dividing up geological events into several probability categories and classes. Such methodology has been widely developed in the last decades in the Croatian subsurface—mostly in the Croatian Pannonian Basin System (CPBS). Through the adaptation of geological categories, it was also applied in hybrid, i.e., stochastic, models developed in the CPBS (Drava Depression), mostly for inclusion of porosity values. As the robustness of this methodology is very high, it was also modified to estimate the influence of water-flooding in increasing oil recovery in some proven Neogene sandstone reservoirs in the CPBS (Sava Depression). This new modification is presented to be applied to geological risk calculation, intending to assess the safety of geological environment storage in deep wells, where spent nuclear fuel (SPN) would be disposed, a subject of great importance. The conceptual study encompassed the magmatic and metamorphic rocks in the pre-Neogene basement of the CPBS, intended to be used for such purpose. Regionally distributed lithologies are considered for nuclear waste disposal purpose, in order to detect the safest ones, considering petrophysical values, water saturation, recent weathering and tectonic activity.
Thermal Performance Enhancement in Flat Plate Solar Collector Solar Water Heater: A Review
Authors: Shamsul Azha Nurril Ikmal , Hussin Hilmi , Nasif Mohammad Shakir , Hussain Tanweer
Published: June 2020

Various studies to improve the thermal performance of flat plate solar collector (FPSC) solar water heater have been conducted, and more are currently in progress. This study aims to review existing methods on thermal performance enhancement for FPSC and discuss on heat-transfer enhancement using vibration and its potential application for FPSC. Ten methods for improving thermal performance are identified, which include applications of nanofluids, absorber coatings, phase change materials (PCM), thermal performance enhancers, FPSC design modifications, polymer materials, heat loss reduction, mini and micro channel and heat-transfer enhancement using vibration. An examination of heat-transfer enhancement using vibration in low frequency ranges for an evacuated-tube solar collector (ETSC) solar water heater system showed that it can potentially achieve heat-transfer enhancement of up to 78%. Nevertheless, there is still a lack of research on the applications of heat-transfer enhancement using vibration on FPSC to date.
A Comprehensive Energy and Exergoeconomic Analysis of a Novel Transcritical Refrigeration Cycle
Authors: Tashtoush Bourhan , Megdouli Karima , Elakhdar Mouna , Nehdi Ezzedine , Kairouani Lakdar
Published: June 2020

A comprehensive energy and exergoeconomic analysis of a novel transcritical refrigeration cycle (NTRC) is presented. A second ejector is introduced into the conventional refrigeration system for the utilization of the gas-cooler waste heat. The thermodynamic properties of the working fluid are estimated by the database of REFPROP 9, and a FORTRAN program is used to solve the system governing equations. Exergy, energy, and exergoeconomic analyses of the two cycles are carried out to predict the exergetic destruction rate and efficiency of the systems. The optimum gas cooler working pressure will be determined for both cycles. A comprehensive comparison is made between the obtained results of the conventional and the new cycles. An enhancement of approximately 30% in the coefficient of performance (COP) of the new cycle was found in comparison to the value of the conventional cycle. In addition, the results of the analysis indicated a reduction in the overall exergy destruction rate and the total cost of the final product by 22.25% and 6%, respectively. The final product cost of the proposed NTRC was found to be 6% less than that of the conventional ejector refrigeration cycle (CERC), whereas the optimum value of the gas cooler pressure was 10.8 MPa, and 11.4 MPa for the NTRC and CERC, respectively.
Modification of Conventional Sugar Juice Evaporation Process for Increasing Energy Efficiency and Decreasing Sucrose Inversion Loss
Authors: Chantasiriwan Somchart
Published: June 2020

The evaporation process, boiler, and turbine are the main components of the cogeneration system of the sugar factory. In the conventional process, the evaporator requires extracted steam from the turbine, and bled vapor from the evaporator is supplied to the juice heater and the pan stage. The evaporation process may be modified by using extracted steam for the heating duty in the pan stage. This paper is aimed at the investigation of the effects of this process modification. Mathematical models of the conventional and modified processes were developed for this purpose. It was found that, under the conditions that the total evaporator area is 13,000 m2, and the inlet juice flow rate is 125 kg/s, the optimum modified evaporation process requires extracted steam at a pressure of 157.0 kPa. Under the condition that the fuel consumption rate is 21 kg/s, the cogeneration system that uses the optimum modified evaporation process yields 2.3% more power output than the cogeneration system that uses a non-optimum conventional cogeneration process. Furthermore, sugar inversion loss of the optimum modified process is found to be 63% lower than that of the non-optimum conventional process.
Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda minima
Authors: Kim Byoung Ha , Lee Won-Yung , Trinh Tuy An , Pyo Jae Sung , Lee Sooyeun , Kim Chang-Eop , Lee Dong Hwan , Park Eun-Seok , Kang Ki Sung
Published: June 2020

Janus kinase 3 (JAK3) inhibitors have been used effectively in the treatment of several cases of alopecia universalis and its variants. Our study aims to evaluate whether the emulsion extract of brevilin A from Centipeda minima (CMX) stimulates hair regrowth in a clinical trial, as a JAK3 inhibitor, combined with network pharmacology-based analysis. CMX showed potent inhibition of JAK3 in a concentration-dependent manner. Significant differences in total hair count, terminal hair count, and anagen hair count from the baseline to 24 weeks were observed between the placebo and CMX subjects. The gene set enrichment analysis showed that the targets of CMX are mainly associated with the JAK-STAT signaling pathway, cytokine–cytokine receptor interactions, and the MAPK signaling pathway. This study suggests that the medicinal herbal extract CMX is useful in the treatment of mild to moderate vertex balding that contribute to the visible improvements in hair growth observed in treated patients.
Cell Factories for Industrial Production Processes: Current Issues and Emerging Solutions
Authors: Navarrete Clara , Jacobsen Irene Hjorth , Martínez José Luis , Procentese Alessandra
Published: June 2020

Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.
The Accra Confession as Dangerous Memory: Reformed Ecclesiology, the Ecological Crisis, and the Problem of Catholicity
Authors: Kuo Henry S.
Published: June 2020

This study presents the Accra Confession as a theological response to the ecological crisis from a Reformed perspective while also addressing its critical weakness, namely the problem of universality in both Reformed ecclesiology and global approaches to ecological destruction. Because of a fragile universality, both Reformed churches and global institutions find it difficult to agree on a concrete plan to address climate change. Theologically, this difficulty arrives not primarily from disagreement with the existence or causes of climate change but how Christian theological values translate concretely to acts of justice. This study proposes a way to ground these discussions on the concept of dangerous memory by resourcing the theology of Johann Baptist Metz. Dangerous memories allow stories of the suffering vanquished to be constitutive to the construction of caritas, which in turn serves as a suitable theological foundation for addressing differing approaches to engaging climate issues. Reading the Accra Confession as dangerous memory, then, provides a valuable resource to the Reformed community by allowing the testimonies of those affected adversely by climate change to substantially inform theological discourses on climate justice.
Mama, Keep Walking for Peace and Justice: Gender Violence and Liberian Mothers’ Interreligious Peace Movement
Authors: Shin Wonchul
Published: June 2020

Focusing on the understudied area of women, religion, and peacebuilding, this essay offers the case study of Liberian mothers’ actions in the interreligious peace movement to address multiple forms of violence in the midst and aftermath of Liberian civil wars. This essay examines three forms of gender violence and their impact on the lives of Liberian women: (1) sexual violence, (2) forced mobilization of child soldiers, and (3) structural poverty. Afterwards, the essay explores the journey of Liberian mothers to peace and justice and analyzes the role of religion(s) in organizing and sustaining the mothers’ interreligious peace movement. Specifically, this essay highlights the concept of motherhood rooted in Pan-African religious traditions as a key moral resource to empower the mothers as peacebuilders and to foster restorative justice in their war-torn nation.
Creating Interstitial Spaces: Muslim Network Organizations in the United Kingdom
Authors: Scott-Baumann Alison , Bunglawala Shenaz
Published: June 2020

This contribution describes the origin and activities of three organizations in the United Kingdom: the British Association for Islamic Studies (BRAIS), the Muslims in Britain Research Network (MBRN) and Muslim Engagement and Development (MEND), discussing them against the backdrop of a dominant government-led securitization agenda. Having each held leading positions in one of these initiatives, the authors analyze the attempts of these organizations to endorse bonds and bridges between stakeholders at universities, community-based organizations and media, in order to combat distorted views on Islam and Muslims in current British society. Constructive work has taken place as they created new interstitial spaces in which stakeholders have conversed and benefitted from each other’s insights. At the same time, these interstices are being constricted in such a way that the new spaces risk being squeezed by the ‘agenda of misrecognition’, a defensive closed fist. Based on their experiences, the authors define a possible agenda to consolidate the interstitial spaces that these organizations have managed to occupy.
Fire Blight Disease Detection for Apple Trees: Hyperspectral Analysis of Healthy, Infected and Dry Leaves
Authors: Skoneczny Hubert , Kubiak Katarzyna , Spiralski Marcin , Kotlarz Jan , Mikiciński Artur , Puławska Joanna
Published: June 2020

The effective and rapid detection of Fire Blight, an important bacterial disease caused by the quarantine pest E.amylovora, is crucial for today’s horticulture. This study explored the application of non-invasive proximal hyperspectral remote sensing (RS) in order to differentiate the healthy (H), infected (I) and dry (D) leaves of apple trees. Analysis of variance was employed in order to determine which hyperspectral narrow spectral bands exhibited the most significant differences. Spectral signatures for the range of 400–2500 nm were acquired with Thermo Scientific Evolution 220 and iS50NIR spectrometers. The selected spectral bands were then used to evaluate several RS indices, including ARI (Anthocyanin Reflectance Index), RDVI (Renormalized Difference Vegetation Index), MSR (Modified Simple Ratio) and NRI (Nitrogen Reflectance Index), for Fire Blight detection in apple tree leaves. Furthermore, a new index was proposed, namely QFI. The spectral indices were tested on apple trees infected by Fire Blight in a quarantine greenhouse. Results indicated that the short-wavelength infrared (SWIR) band located at 1450 nm was able to distinguish (I) and (H) leaves, while the SWIR band at 1900 nm differentiated all three leaf types. Moreover, tests using the Pearson correlation indicated that ARI, MSR and QFI exhibited the highest correlations with the infection progress. Our results prove that our hyperspectral remote sensing technique is able to differentiate (H), (I) and (D) leaves of apple trees for the reliable and precise detection of Fire Blight.
Dependent-Gaussian-Process-Based Learning of Joint Torques Using Wearable Smart Shoes for Exoskeleton
Authors: Yang Jiantao , Yin Yuehong
Published: June 2020

Estimating the joint torques of lower limbs in human gait is a highly challenging task and of great significance in developing high-level controllers for lower-limb exoskeletons. This paper presents a dependent Gaussian process (DGP)-based learning algorithm for joint-torque estimations with measurements from wearable smart shoes. The DGP was established to perform data fusion, and serves as the mathematical foundation to explore the correlations between joint kinematics and joint torques that are embedded deeply in the data. As joint kinematics are used in the training phase rather than the prediction process, the DGP model can realize accurate predictions in outdoor activities by using only the smart shoe, which is low-cost, nonintrusive for human gait, and comfortable to wearers. The design methodology of dynamic specific kernel functions is presented in accordance to prior knowledge of the measured signals. The designed composite kernel functions can be used to model multiple features at different scales, and cope with the temporal evolution of human gait. The statistical nature of the proposed DGP model and the composite kernel functions offer superior flexibility for time-varying gait-pattern learning, and enable accurate joint-torque estimations. Experiments were conducted with five subjects, whose results showed that it is possible to estimate joint torques under different trained and untrained speed levels. Comparisons were made between the proposed DGP and Gaussian process (GP) models. Obvious improvements were achieved when all DGP r2 values were higher than those of GP.
Social Investment in Aotearoa/New Zealand: Meaning and Implications
Authors: O’Brien Michael
Published: June 2020

Social investment has been the leit motif for the development of a range of social service provisions in Aotearoa/New Zealand for the last decade. It involves a particular approach, using data to target decisions and inform directions for such key areas as social security, care and protection of children and delivery of social services. There are serious questions about the statistical base which informs the approach and the implications for disadvantaged, marginalised and targeted populations, while poverty is neglected, sidelined and/or treated as resulting from individual failure. The Aotearoa/New Zealand model of social investment represents a significant departure from needs based, equity informed welfare provision.
Assessment of Diversity Outcomes in American Medical School Admissions: Applying the Grutter Legitimacy Principles
Authors: Baugh Aaron , Baugh Reginald F.
Published: June 2020

In the last 30 years, except for female participation, the enrollment of Latinx, African Americans, Native Americans, Alaskan natives, and disadvantaged students in medical school has been constant; however, increasing enrollment of these minority populations is feasible, if admissions committees make two changes in approach. First, the traditional belief that matriculation merit is a linear function of past academic performance must be rejected. Second, once the threshold needed to complete medical school in four years and to pass licensing examinations at the first attempt has been met, all candidates are equally qualified, and matriculation decisions must be based, in part, on societal interests. In Grutter vs. Bollinger, the United States Supreme Court determined that graduate admission committees can and should consider societal interests. Each admission decision represents a substantial government investment in each student, as the Medicare Act directly subsidizes much of the cost of medical education. As Grutter explained, there is a societal interest in the public having confidence in, and access to, the medical school training that will prepare tomorrow’s medical, professional, and political leaders. Our analysis suggests that medical school admissions are biased towards academic achievement in matriculants, beyond acceptable thresholds for graduation and licensure. We believe medical schools must shift their admissions strategies and consider noncognitive factors in all candidates as determinative once minimum acceptable academic standards have been met.
How Energy Retrofit Maintenance Affects Residential Buildings Market Value?
Authors: Mecca Umberto , Moglia Giuseppe , Piantanida Paolo , Prizzon Francesco , Rebaudengo Manuela , Vottari Antonio
Published: June 2020

By now, it is clear the built environment could play an important role in fighting climate change, since it accounts for around 39% of global energy-related carbon emissions. Generally speaking, Italian residential stock is over 50 years old and around 16% of that needs large interventions due to its poor maintenance condition. So, the maintenance in this context can play a pivotal role in acheiving both energy efficiency and asset valorization. Introduced by a reference framework for the question in the title, this paper presents the case study: a portion of a working-class neighborhoods near the metropolitan city of Turin, marked by very recurrent typologies for the period (early seventies). The local real estate market is discussed to investigate the extraordinary maintenance impact on the property values: the paper considers the market value increase due to the energy class upgrade and the external look improvement. Individual owners putting money on this group of works get a very cost-effective investment and take advantage of Italian legislation supporting these kinds of interventions: the whole is greater than the sum of its parts and in turn greater than the cost assumed for the renovation work.
Towards a Sustainable and Adaptive Groundwater Management: Lessons from the Benalup Aquifer (Southern Spain)
Authors: Vélez-Nicolás Mercedes , García-López Santiago , Ruiz-Ortiz Verónica , Sánchez-Bellón Ángel
Published: June 2020

Reversing the chemical and quantitative impacts derived from human activity on aquifers demands a multidisciplinary approach. This requires, firstly, to update the hydrogeological knowledge of the groundwater systems, which is pivotal for the sustainable use of this resource, and secondly, to integrate the social, economic and administrative reality of the region. The present work focuses on the Benalup aquifer, whose exploitation plays a major role in the economy of the area, based mainly on irrigated agriculture. This activity has had negative consequences for the aquifer in quantitative and chemical terms, leading to its declaration as in poor condition. The study presented here shows the results obtained from the application of hydrogeological techniques, remote sensing and citizen participation tools, which have allowed us to deepen and improve the current knowledge of the system’s hydrogeological, geometric, administrative and social aspects. Additionally, the lessons learned from this case study are analyzed. The deficiencies detected are discussed, and alternatives aimed at the sustainable use of groundwater are proposed, such as the possibility of a joint use of surface and groundwater resources, the creation of a Water User Association responsible for the management of groundwater and the need for greater efforts aimed at educating and raising awareness of water conservation among citizens.
Summer Farmers, Diversification and Rural Tourism—Challenges and Opportunities in the Wake of the Entrepreneurial Turn in Swedish Policies (1991–2019)
Authors: Rytkönen Paulina , Tunón Håkan
Published: June 2020

Since the 1990s Swedish authorities have increasingly treated summer farms as businesses, expecting them to generate profits like any other firm. However, in addition to being financially independent, summer farms are expected to provide a number of services, to help maintain biological heritage, provide beautiful landscapes for tourists, and much more. Summer farmers are also forced to co-exist with other local stakeholders that base their activities on the same resources, e.g., adventure and nature-based tourism, agriculture, and other businesses. All of this creates a number of entrepreneurial challenges but can also open new windows of opportunity. The response of summer farmers has been to diversify activities to cope with shrinking income and the seasonal character of their trade. Most new business strategies include tourism or increasing the number of cattle rationalizing animal husbandry. The strategies have partly been influenced by policies and partly by new market opportunities. Departing from a business, spatial and institutional contextual analysis we identified five main entrepreneurial strategies, three of which are related to rural tourism, one is related to increasing the animal herd and the fifth is a no-strategy, maintaining status quo. This article analyses the reality of summer farms from a business perspective. The main questions to be answered are: How have summer farmers responded to the entrepreneurial turn in regional development policies? Which are their main business challenges and opportunities?
A Social Network Analysis of the Spanish Network of Smart Cities
Authors: Serrano Ivan , Calvet-Mir Laura , Ribera-Fumaz Ramon , Díaz Isabel , March Hug
Published: June 2020

This paper explores the relations of centrality and hierarchy between cities and firms implementing Smart City strategies in the context of the Spanish Network of Smart Cities (RECI). While the literature has usually focused on the global dimension of cities and firms networks, exploring a national case offers interesting insights about the presence of multinational firms in these contexts and the role played by medium-sized cities in their market expansion. The analysis is based on a two-mode network of cities and firms participating in Smart City projects with the usual measures of betweenness, in-degree and closeness, as well as computing the Gini index for each of them to assess the levels of inequality. We then explore whether the structural advantages of participating in these networks have a leveling effect or rather reinforce existing hierarchies of cities. Second, we explore how firms are intertwined in Smart City projects and whether medium-sized local firms have a relevant presence. Our findings suggest these networks become a regional gateway for multinational firms to expand their presence in Smart City national markets, rather than empowering medium-sized cities and small national firms.
The Role of Renewable Energy Resources in Sustainability of Water Desalination as a Potential Fresh-Water Source: An Updated Review
Authors: Ahmadi Esmaeil , McLellan Benjamin , Mohammadi-Ivatloo Behnam , Tezuka Tetsuo
Published: June 2020

Desalination is becoming a practical option to meet water demand in an increasing number of locations that are facing water scarcity. Currently, more than 150 countries in the world are already using desalination technologies, which account for about one percent of the world’s drinking water. Although for specific regions, desalination is the only feasible solution to close the supply–demand gap (for example the production of desalinated seawater in the Middle East is predicted to rise almost fourteen-fold by 2040), the sustainability of desalination systems is still remarkably under question. This review aims first to investigate the technical and economic trends and environmental and social aspects of desalination systems and then, in the second stage, to give an overview of the role of renewable energy technologies in the sustainability of the future water systems with an increasing share of desalination.
Relationship between Psychological Capital and Quality of Life: The Role of Courage
Authors: Santisi Giuseppe , Lodi Ernesto , Magnano Paola , Zarbo Rita , Zammitti Andrea
Published: June 2020

Quality of life is a multidimensional concept, a construct influenced by objective and subjective factors that include the evaluation of functional, physical, social, and emotional aspects of the person. The recent contributions of positive psychology present the quality of life as a fundamental indicator for health promotion and prevention strategies. In the recent psychological studies about this topic, courage demonstrated to positively affect several work behavioral outcomes, personal identity, and prosocial actions. Courage promotes change, innovation, and coping skills to achieve aims, and it correlates positively with many individual resources. The aim of the study was to investigate, according to the positive psychology approach, the relationships between psychological capital and two dimensions of quality of life—life satisfaction and flourishing—with particular attention to the mediation function performed by courage. The research was attended by a convenience sample of 807 Italian workers, balanced by gender, belonging to public, private, and non-profit organizations, and recruited on a voluntary basis. Participants responded to a structured online questionnaire containing the following measures: Psychological Capital Questionnaire, Courage Measure, Satisfaction with Life Scale, and Flourishing Scale. Cronbach’s alpha on each scale showed very good internal consistency. The collected data were analyzed according to a model of linear structural equations. In the first step, we conducted a confirmatory factor analysis (CFA) to test the model fit of the measurement model; in the second step, we verified the mediation hypothesis through Process v.3.1. Finally, the correlations were implemented using SPSS 20.0. The results showed that, in general, psychological capital predicts life satisfaction and flourishing, with an indirect mediation effect of courage only on flourishing. Two main conclusions emerged from the study: flourishing and life satisfaction are representative indicators of the quality of life; courage emerges as an important psychological resource that supports the individual to face and manage the uncertainties of the risk society.
Revealing Motives for Car Use in Modern Cities—A Case Study from Berlin and San Francisco
Authors: von Behren Sascha , Bönisch Lisa , Niklas Ulrich , Chlond Bastian
Published: June 2020

Car use in modern cities with a well-developed public transit is more sophisticated to explain only through hard factors such as sociodemographic characteristics. In cities, it is especially important to consider motives for car use. Therefore, we examined two modern cities with a high modal share of non-motorized modes and public transit to answer the question: How do the affective and instrumental motives influence car use in such cities? The used data set was collected in Berlin and San Francisco. To investigate the role of motives, we applied an ordered hybrid choice model (OHCM) with a probit kernel. Based on the OHCM we explained more than 14% of the overall heterogeneity and gave further insights to the decision-making process. The affective motive had a strong influence on car use frequency, whereby the instrumental aspects did not matter. Furthermore, an effect resulting from age could not be determined for the affective motives in these cities. Results suggest people are more likely to use cars for affective motives despite the city’s adversities. For these people it is difficult to achieve a shift to alternative means of transport. The only way to intervene here is through regulatory intervention.
Implementing Water Policies in China: A Policy Cycle Analysis of the Sponge City Program Using Two Case Studies
Authors: Liang Xiao , Liang Yuqing , Chen Chong , van Dijk Meine Pieter
Published: June 2020

This study carries out an in-depth analysis of urban water policy implementation in China through a policy cycle analysis and case study of Sponge city program. The policy cycle analysis articulates discrete steps within the policy formulation and implementation process, while the case studies reflect the specific problems in water project implementation. Because of the principal–agent relation between central and local government, a ‘‘double wheel’’ policy cycle model is adopted to reflect the policy cycles at central level and at local level. Changde city and Zhuanghe city, two demo cities in the Sponge city program, are chosen for the analysis. The policy cycle analysis shows that the central government orders local government to implement policy without clear direction on how to attract private sector participation. The evaluation of central government did not include private sector involvement, nor the sustainability of the investments. This promotes the local government’s pursuit of project construction completion objectives, without seriously considering private sector involvement and operation and maintenance (O&M) cost. The local governments do not have political motivation and experiences to attract private investments into project implementation. The case study in the two demo cities shows that local government subsidies are the main source of O&M funding currently, which is not sustainable. The water projects are not financially feasible because no sufficient revenue is generated to cover the high initial investments and O&M cost. The lack of private sector involvement makes it difficult to maintain adequate funding in O&M, leading to the unsustainability of the water projects. It is not easy to achieve private sector involvement, but it could be the key to realizing urban water resilience in a more sustainable way.
Sustainable Value Co-Creation and Digital Health: The Case of Trentino eHealth Ecosystem
Authors: Botti Antonio , Monda Antonella
Published: June 2020

This paper aims to develop a theoretical framework based on recent service theories, such as service-dominant logic and service science, and on the concept of service ecosystems. The identification of the main elements of service ecosystems allows for pinpointing the main drivers for sustainable value co-creation, which is intended as the creation in the long run of new service solutions set up with and for end-users to guarantee a better service for the whole society. Given the high interactivity required in the relationship between players involved in digital health services, we decided to apply the developed framework to eHealth, to re-read the eHealth sector as a service ecosystem. The model is tested through a case study represented by digital healthcare in the Autonomous Province of Trento, which represents a best practice in this sector. The results confirm the presence of the main elements of the service ecosystem (actors, resource integration, technology, institutions) in the eHealth sector and show how their integration favours the creation of new resources, new uses of technology and new institutions that produce innovation and sustainable value co-creation. The originality of the work lies in the reconceptualization of the digital health sector from a new perspective based on the assumptions of service-dominant logic, that allow us to analyze the eHealth ecosystem in a holistic and system view.