bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro and in vivo evaluation of anti-inflammatory activities of ethanol extract from Lom-Am-Ma-Pruek remedy for pain relief
Authors: Itharat Arunporn , Thongmee Pun , Piwngam Krit , Inprasit Janjira , Makchuchit Sunita , Kuropakornpong Pranporn , Davies Neal M.
Published: December 2024

Background and purpose:

Lom-Am-Ma-Pruek (LAMP) remedy has been used in Thai traditional medicine to relieve pain associated with the inflammatory process. The anti-inflammatory activity and bioactivity of LAMP in an animal model have not been previously investigated. We evaluated the in-vitro and in-vivo anti-inflammatory activity of LAMP ethanol extract.

Experimental approach:

The anti-inflammatory activity of LAMP and its plant ingredients were investigated on lipopolysaccharide-stimulated NO, PGE2, and TNF-α release from RAW264.7 cells. Furthermore, the stability of LAMP under biological and chemical accelerated conditions was evaluated using the Griess reaction assay and HPLC. Lastly, rat models with ethyl phenylpropionate (EPP)-induced ear edema and carrageenan-induced paw edema were utilized to assess anti-inflammatory activity.

Findings/Results:

LAMP possessed potent inhibitory effects on NO, PGE2, and TNF-α production with IC50 values of 24.90 ± 0.86, 4.77 ± 0.03, and 35.01 ± 2.61 µg/mL, respectively. In addition, LAMP extract demonstrated stable biological activity, anti-inflammatory effects, and phytochemical content stability under stress conditions. Additionally, 0.5%, 1%, and 2% w/v LAMP significantly inhibited EPP-induced rat ear edema over time equivalent to 5% w/v phenylbutazone. LAMP at 180, 375, and 750 mg/kg also considerably reduced carrageenan-induced rat paw edema 2 h after carrageenan administration compared to phenylbutazone at 250 mg/kg.

Conclusion and implications:

LAMP has anti-inflammatory activity by inhibiting PGE2 formation. These findings are consistent with the efficacy and traditional use of the LAMP remedy in treating inflammatory diseases.
Exploring the inhibitory potential of xanthohumol on MEK1/2: a molecular docking and dynamics simulation investigation
Authors: Gholizadeh Siahmazgi Zohreh , Irani Shiva , Ghiaseddin Ali , Soutodeh Fereshteh , Gohari Zahra , Afifeh Jaber , Pashapouryeganeh Amirreza , Samimi Hilda , Naderi Mahmood , Fallah Parviz , Haghpanah Vahid
Published: December 2024

Background and purpose:

Xanthohumol (Xn), a small molecule found in Humulus lupulus, has shown promise as an anti-cancer compound. This in silico study was performed to understand the mechanism of action of Xn as a natural compound on MEK1/2 by simulation.

Experimental approach:

After ligand and protein preparation, the best binding energy was determined using Autodock 4.2. Additionally, molecular dynamics simulations of the MEK1/2-Xn and BRaf-MEK1/2-Xn complexes were conducted using GROMACS 2022.1 software and compared to the complexes of MEK1/2-trametinib (Tra) and BRaf-MEK1/2-Tra.

Findings/Results:

The docking results revealed that the best binding energies for MEK1-Xn (-10.70 Kcal/mol), MEK2-Xn (-9.41 Kcal/mol), BRaf-MEK1-Xn (-10.91 Kcal/mol), and BRaf-MEK2-Xn (-8.54 Kcal/mol) were very close to those of the Tra complexes with their targets, MEK1 and MEK2. Furthermore, Xn was found to interact with serine 222 at the active site of these two kinases. The results of the molecular dynamics simulations also indicated that Xn induced changes in the secondary structure of the studied proteins. The root mean square of proteins and the mean radius of gyration showed significant fluctuations.

Conclusion and implications:

The findings of the study suggested that Xn, as a novel bioactive compound, potentially inhibits the MEK1/2 function in cancer cells.
Mario Molina: Un científico socialmente comprometido
Authors: Velázquez de Castro González Federico
Published: December 2024

En el presente artículo se comenta la trayectoria de uno de los científicos más relevantes del siglo XX, el doctor Mario Molina. Oriundo de México, tras obtener allí su licenciatura, amplía sus estudios superiores en California, incorporándose a un grupo de trabajo sobre química atmosférica, en el que participó en una investigación trascendental: cómo unos productos de excelentes propiedades (incluida la ausencia de toxicidad) y utilizados en aplicaciones residenciales, comerciales e industriales, podían ser destructores del ozono estratosférico si alcanzaban las capas altas de la atmósfera. Este descubrimiento le llevó a recibir el Premio Nobel de Química, pero su mérito se amplió al implicarse socialmente para que fuera posible la prohibición de los productos responsables. También es destacable su retorno a México para trabajar por la mejora de su país. Este perfil profesional que rehúye el aislamiento y elige dar un objetivo social a sus conocimientos para que se reviertan en una mejora de la población (especialmente de los más desfavorecidos), es hoy sumamente necesario para abordar los importantes desafíos ambientales.
A feature selection and scoring scheme for dimensionality reduction in a machine learning task
Authors: UTEN EMMOH PHILEMON , Ifeanyi Eke Christopher , Moses Timothy
Published: December 2024

Selection of important features is very vital in machine learning tasks involving high-dimensional dataset with large features. It helps in reducing the dimensionality of a dataset and improving model performance. Most of the feature selection techniques have restriction in the kind of dataset to be used. This study proposed a feature selection technique that is based on statistical lift measure to select important features from a dataset. The proposed technique is a generic approach that can be used in any binary classification dataset. The technique successfully determined the most important feature subset and outperformed the existing techniques. The proposed technique was tested on lungs cancer dataset and happiness classification dataset. The effectiveness of the proposed technique in selecting important features subset was evaluated and compared with other existing techniques, namely Chi-Square, Pearson Correlation and Information Gain. Both the proposed and the existing techniques were evaluated on five machine learning models using four standard evaluation metrics such as accuracy, precision, recall and F1-score. The experimental results of the proposed technique on lung cancer dataset shows that logistic regression, decision tree, adaboost, gradient boost and random forest produced a predictive accuracy of 0.919%, 0.935%, 0.919%, 0.935% and 0.935% respectively, and that of happiness classification dataset produced a predictive accuracy of 0.758%, 0.689%, 0.724%, 0.655% and 0.689% on random forest, k-nearest neighbor, decision tree, gradient boost and cat boost respectively, which outperformed the existing techniques.
Calidad de la gestión de enseñanza bajo la modalidad b-Learning: Realidad desde la formación en la carrera ingeniería electrónica
Authors: Rivero Rodríguez Enma Carolina
Published: December 2024

A lo largo de la historia, las instituciones de educación han sufrido transformaciones debido no únicamente a los cambios socioeconómicos, sino también a las diversas posturas científicas y pedagógicas de cada momento histórico. Sin embargo, ahora más que nunca, en tiempos actuales y ante una sociedad creciente, fluctuante y cada vez más exigente, las instituciones educativas enfrentan retos que indudablemente implican variaciones, si es que se desea dar respuesta a tan diversas necesidades y desafíos que afrontan las sociedades del siglo XXI.

Es esta creciente rapidez e impredecibilidad de los cambios en el entorno y, por ende, los consiguientes desafíos que demanda actualmente el gerenciamiento de las organizaciones, lo que las orienta hacia la competitividad y, especialmente hacia la innovación. En consecuencia, la implementación de modalidades educativas creativas es considerada como un recurso destinado a elevar la capacidad y habilidad de las instituciones para desempeñar una acción o actividad, que facilita la adquisición, construcción y utilización de acciones innovadoras.

Por consiguiente, una alternativa responsable por parte de las instituciones de educación superior en su calidad de organizaciones sociales, en abordar esta metamorfosis mediante la adopción de modernas modalidades de enseñanza, específicamente la educación a distancia con la llamada educación virtual, en la cual se han incorporado las Tecnologías de la Información y Comunicación (TIC) que permiten una comunicación más fluida entre el docente y el participante, con las correspondientes mejoras en el proceso educativo.

En particular, en la educación superior, tanto a nivel nacional como mundial, se observa una tendencia a la incorporación de las TIC que va desde el soporte y uso de las tecnologías como apoyo en los cursos presénciales hasta la virtualización total de programas de formación, donde la fusión de ambas conforma una de las modalidades más acogidas, la semipresencial.
Devenir geográfico e histórico de Urachiche. Homenaje por su cuatricentenario
Authors: Paradas Pérez Luis Alberto
Published: December 2024

El libro que se presenta al público lector interesado tiene el propósito de mostrar los más relevantes elementos de geografía descriptiva y clásica que caracterizan al Municipio Urachiche del Estado Yaracuy, como también la sucesión de acontecimientos históricos de mayor representatividad en esta comunidad yaracuyana del Centro Occidente de Venezuela, ordenados y presentados en estricto orden cronológico. Para su organización y presentación se procedió a una minuciosa revisión de fuentes documentales en donde la información se clasificó y procesó atendiendo la delimitación cognitiva de cada una de las dos disciplinas a las cuales se circunscribe el trabajo, la geografía y la historia, seleccionado en esta oportunidad, a pesar de que existe en Venezuela un enfoque interdisdisciplinario propuesto por el equipo de investigadores encabezados por Ramón Tovar, la geohistoria, con el que se ha trabajado en investigaciones anteriores.
Se conocen las diferentes escuelas de pensamiento por las que ha travesado la geografía, como lo son, determinismo, posibilismo, el enfoque cuantitativo, geografía radical y geografía humanística, como también las tendencias historiográficas, entre ellas anecdótica, romántica, positivista, del materialismo histórico, historia total y la subjetividad en historia, cada una con un relevante soporte epistemológico, pero el propósito de esta obra, es presentar una aproximación a la geografía y la historia general del lugar, pues de esto adolece la mayoría de las comunidades venezolanas, siempre impregnadas de una visión centralista y capitalina. Se les ha asignado un papel de simples receptoras de sucesos y hechos, lo cual no es así.
Sosyo-Psikolojik Açıdan Kur’an’da Uyma Davranışı Bağlamında İtaat Kavramı
Authors: Karakullukçu Şevval
Published: December 2024

Sosyal bir varlık olan insan, diğer insanlar ile etkileşim içinde olmaya, grup içinde yaşamaya ve o grup tarafından kabul görmeye ihtiyaç duyar. Bu ihtiyaç, sosyal etkinin bir sonucu olarak kendini gösterir; bireyler, diğerlerinin düşünceleri, davranışları veya inançları tarafından etkilenerek kendi davranışlarını değiştirebilirler. Uyma davranışı da bu etkileşimin bir yansımasıdır. Uyma davranışının benimseme, özdeşleşme ve itaat gibi farklı tezahürleri vardır. Bu çalışmada itaat kavramı, uyma davranışı bağlamında Kur’an-ı Kerim’de yer alan çeşitli kıssa ve ayetlerle ilişkilendirilerek incelenmiştir. Çalışmanın amacı, itaati etkileyen üç faktörün Kur’an-ı Kerim’deki karşılıklarını ileri sürmektir. Bu çalışmada doküman inceleme tekniği kullanılmaktadır. Çalışmanın amacı doğrultusunda uyma davranışı incelenmiş, itaat kavramı farklı tanımlar ile açıklanmış, sonra Stanley Milgram’ın deneyine değinilmiş ve bu deneyden hareketle itaate etki eden temel faktörlerden a) fiziksel yakınlık b) otorite kaynağı c) grup etkisi başlıkları açıklanmış ve son olarak bu başlıklar Kur’an-ı Kerim’den bazı ayetler ile ilişkilendirilerek açıklanmıştır. Sonuç olarak insanın itaatine etki eden faktörler Kur’an-ı Kerim’deki ayetler bağlamında da incelendiğinde Kur’an-ı Kerim’de de fiziksel yakınlık, otorite kaynağı ve grubun itaat üzerindeki etkisi ile karşılaşılmıştır. İtaatin sosyolojik ve psikolojik olarak incelenmesi, toplumsal huzur ve düzen için önemlidir.
Mu‘tezile’de Tövbenin Kamu Hukukuna Yansıyan Boyutu
Authors: Maraz Hüseyin
Published: December 2024

Bu makale, sosyo-ahlakî yasal yönleriyle tövbe konusunu Mu’tezilî bakış açısıyla konu edinmektedir. Makalede tövbenin Allah’ın hukukuna taalluk eden yönünden ziyade insan hak ve onurunu ilgilendiren boyutu incelenecektir. Özellikle birey ve kamuya sirayet eden ihlâller nedeniyle gerekli olan tövbenin ahlakî, dinî ve hukukî kaideleri irdelenecektir. Mu‘tezilî teolojide tövbe fiilinde gerekli unsurlar, tövbe etmeyi gerektiren koşullar ve günaha karşı zorunlu yaptırımlar analitik bir yöntemle tahlil edilecektir. Makalede detaylı kavram analizlerine yer verilmeyecek ana tema Mu‘tezile’ye özgü görüşlerle sınırlandırılacaktır. Fakat güncel ile bağıntıyı sağlama gayesiyle kamu hakları ve menfaatini konu edinen modern dönem çalışmalarından da istifade edilecektir. Makalenin özgünlüğü tövbe konusunu bireysel dinî bir tercihin ötesine taşıyarak kamu ahlakı çerçevesinde yasal boyutlarıyla ele alacak olmasıdır. Böylece mesele, salt dinî içeriğiyle ele alınmayacak özellikle kamu hukuku dikkate alınarak sosyo-ahlakî bir boyut da eklenmiş olacaktır. Sonuç olarak kamu hukuku ve menfaatine yönelik ihlâl durumlarında tövbenin ahlakî ve yasal yaptırımı gerektiren bir ödev olduğu vurgulanarak onarıcı ve yapıcı yönü belirtilecektir.
Yaşlı Bireylerin Hayat, Din ve Değer Algıları ile Başa Çıkma Süreçleri Üzerine Bir Araştırma: Ömür Dediğin Programı Örneği
Authors: Özler Abdullah , Tokur Behlül
Published: December 2024

Bu araştırma, “Ömür Dediğin” programı özelinde yaşlı bireylerin hayat, din ve değer algıları ile başa çıkma süreçlerini anlamak amacıyla gerçekleştirilmiştir. Bu kapsamda yaşlı bireylerin konuk olarak yer aldığı "Ömür Dediğin" programı doküman olarak ele alınmış ve incelenmiştir. Nitel araştırma deseninde kullanılan amaçlı örneklem tekniği ile ilgili program bölümleri tespit edilmiştir. Bu doğrultuda çalışmanın grubunu “Ömür Dediğin” programının 20.10.2023 tarihi itibariyle yayınlanan 315 bölümünün tamamı, örneklemini ise “Ömür Dediğin” programının 43 bölümü içerisinde yer alan toplam 45 katılımcı oluşturmaktadır. Çalışmada elde edilen görüşlerin analizinde ise tematik içerik analizi ve betimsel analiz tercih edilmiştir. Araştırma sonuçlarına göre yaşlı bireylerin hayat ve değer algılarına kaynaklık etmesi açısından dinin merkezi bir konumda olduğu görülmüştür. Yaşlılık döneminin kendine has gelişim özelliklerine bağlı olarak yaklaşmakta olan ölüm bireyin zihninde ahiret düşüncesini baskın bir konuma getirirken fiziksel gücün azalmasının da etkisiyle bireyin ihtiyaçlarının karşılanması açısından dua da önemli bir yer tutmaktadır. Yaşlı bireyler açısından şükür, sevgi ve yardımseverlik öne çıkan değerlerdendir. Yaşlı bireylerin karşılaştıkları sıkıntılı ve zorlu süreçler karşısında öncelikle dini başa çıkma stratejilerinden yararlandıkları görülmekle birlikte seküler başa çıkma stratejilerine de başvurdukları tespit edilmiştir.
Ortaokul Öğrencilerinde Deprem ve Tanrı Algısı (Gaziantep İli Örneği)
Authors: Turgut Mehmet
Published: December 2024

İnsan, doğanın karşısındaki çaresizliğini zaman zaman unutur. Mevcut teknolojik ilerlemeler ve maddi güçler bu unutuşu besleyen unsurlar arasında yer alır. Ancak doğanın kendini hatırlatması genellikle acı ve üzüntüyle doludur. Bu bağlamda, doğal felaketlerin en yıkıcı olanlarından biri de depremlerdir. Depremler, yer altındaki fay hatlarının hareket etmesi sonucu ortaya çıkar ve yeryüzünde büyük tahribatlar ve can kayıpları yaratır. Bu tür olaylar insanlar üzerinde derin etkilere sahiptir. Öyle ki maddi ve manevi birçok konu zihin süzgecinden geçirilerek sorgulanmaya başlanır. Depremler yalnızca fiziksel yıkımlara neden olmakla kalmaz, aynı zamanda psikolojik travmalara da yol açar. Özellikle bahse konu olan bireyler, bu tür sorunlardan doğrudan etkilenir. Ergenlik öncesi (Preadolescence) dönemde çocuklar; yeni bir kimlik arayışı içindedirler ve yaşadıkları deprem deneyimlerinden biçimlenirler. Bu dini gelişimin bir aşaması olarak kabul edilen süreçte, böyle bir tecrübenin nasıl bir yönlendirme sağlayacağı merak konusudur. Bu çalışma, depremin bahsi geçen çocuklar üzerindeki Tanrı algısını incelemeyi amaçlamaktadır. Doğal afetlerin, depremin, algının ve Tanrı imajının yanı sıra konuya dair psikolojik yaklaşımlar ve ön ergenlik döneminin dini gelişim özellikleri ele alınmıştır. Teorik çerçeve ışığında yapılan yarı yapılandırılmış görüşme formu eşliğinde nitel mülakatlarla öğrencilerin deprem ve Tanrı algısına ilişkin düşünceleri ortaya konulmuştur. Öğrenciler, Tanrı’nın mutlak güce ve her şeyi yaratma yetisine sahip olduğunu vurgulamışlardır. Ayrıca, depremin Allah tarafından insanlara bir uyarı veya ceza olarak algılandığını belirtmişlerdir. Deprem sonrasında ibadetlerin artması, çalışmanın dikkat çekici sonuçlarından biridir.
Gençlerde Din ve Hayat Algısı: Hallyu Örneği
Authors: Tamer Büşra , Tokur Behlül
Published: December 2024

Kültür zaman içinde değişir ve diğer kültürleri etkileyebilir, dönüştürebilir. Bunlardan birisi olan ve “Kore dalgası” olarak bilinen Hallyu’nun (한류) kültürel etkisi 90’ların sonundan itibaren Asya’nın ötesinde kendisini göstermeye başlamıştır. Türkiye’de Hallyu, TRT’de yayınlanan Güney Kore dizileri ile gençler arasında etkisini artırmıştır. Ergenlik ve ilk yetişkinlik döneminin bireyin din ve hayat algısını şekillendirmedeki yeri göz önüne alındığında bu dönemde gençlerin Hallyu’ya olan ilgilerinin din ve hayat algıları üzerindeki etkisini incelemek oldukça önemlidir. Nitel araştırma yöntemleri kullanılarak Türkiye’deki 14-28 yaş arası genç bireylerle gerçekleştirilen bu çalışmada, liseden yüksek lisansa, farklı seviyelerde eğitim alan 25 kişiden yarı yapılandırılmış mülakat tekniği ile veri toplanmış ve halka açık etkinlikler ile çevrim içi platformlarda katılımcı gözlem gerçekleştirilmiştir. Araştırma süreci boyunca elde edilen gözlem ve mülakat verileri tematik içerik analizi ile incelenmiş ve bulgular bilimsel açıdan yorumlanmıştır. Çalışma kapsamında gençlerin genel olarak Hallyu’yu bir sosyal destek ve başa çıkma mekanizması olarak kullandıkları, kapsayıcı bir hayat anlamına sahip olmadıkları, aynı zamanda din ve Tanrı algılarının güven ve huzur arayışlarını desteklediği görülmüştür. Öte yandan gençlerin, Hallyu öğeleri aracılığı ile sosyal aidiyet ve duygusal destek buldukları, dinî algılarında ise hem pozitif hem de negatif duygular yaşadıkları, çoğunlukla çevresel faktörlerden dolayı bireysel bir dindarlık yaşamayı tercih ettikleri gözlemlenmiştir.
EXPERIMENTAL EVALUATION OF THE COMPARATIVE EFFECTS OF PANASA (ARTOCARPUS HETEROPHYLLUS LAM.) PAKWA PHALA AND BEEJA MAJJA ON SPERMATOGENESIS IN WISTAR ALBINO RATS.
Authors: K.V Greeshma , Faisal Mohammed , Bhat Sudhakar
Published: December 2024

Ayurveda is a holistic medicinal system from India that emphasises the balance of mind, body, and spirit for health maintenance. It heavily relies on local flora, herbs, and natural remedies, focusing on personalised treat-ments. One significant plant in Ayurvedic medicine is Artocarpus heterophyllus Lam, commonly known as jackfruit or ‘Panasa’ in Sanskrit. This plant is widely utilised for its culinary and medicinal properties, including applications such as Brmhana, Mamsavardhaka, Balya, Sukrala, and Vrana Ropana. Jackfruit is rich in pro-teins, fats, iron, carbohydrates, minerals, calcium, thiamine, niacin, riboflavin, vitamin C, and vitamin A.
Moreover, many classical texts have documented the Vrshya action of Panasa Pakwa Phala and Beeja Majja. This study aimed to conduct a comparative experimental evaluation of the Vrshya effects of Panasa Pakwa Phala and Beeja Majja on spermatogenesis. Objective: Comparative Experimental study to evaluate Spermato-genic activity of Pakwa Phala (Fruit) and Beeja Majja (Seed) of Panasa (Artocarpus heterophyllus Lam.).Materials and method: The collection of Artocarpus heterophyllus fruits and seeds was done from the natural habitat of the Udupi district and authenticated. The experimental study assessed the comparative sper-matogenic activity of Panasa Pakwa Phala and Beeja Majja upon internal administration. Result and Discus-sion: In the experimental study, rats given Panasa Pakwa Phala exhibited a significant increase in body weight, a non-significant increase in sperm count, sluggish motility, and a decrease in non-motile sperm. Notably, there was a substantial reduction in amorphous head sperm and a non-significant rise in hookless sperm.
Conversely, rats treated with Panasa Beeja also showed increased body weight but had different results in sperm motility and morphology, with a significant decrease in normal sperm morphology. This activity profile indicates the presence of a spermatogenesis effect more in the test drug Panasa Pakwa Phala than in Panasa Beeja. Con-clusion: The experimental study demonstrated statistically significant results regarding the internal use of Panasa Pakwa Phala and Beeja Majja, showing positive effects on various parameters. The spermatogenesis effect is more important with the Panasa Pakwa Phala test drug than Panasa Beeja.
A PHARMACEUTICO-ANALYTICAL EVALUATION OF DWIBHUJA RASA
Authors: K Namitha , A K Muraleedharan
Published: December 2024

In contemporary times, Rasaushadhis are increasingly becoming the drug of choice for effectively managing
chronic ailments, reflecting their importance and potential in modern healthcare. Rasa preparations are tasteless,
adequate in small doses, fast-acting, and have a long shelf life, making them easy to handle and highly valuable in
therapeutic applications. Here is a pharmaceutical-analytical evaluation of Dwibhuja Rasa, explained in
Rasayogasagara which indicates Navajwara. To date, no scientific studies have been carried out on this
formulation. Suddha Hingula and Jayapala are given Mardana in Jambeera Swarasa for time duration and made
into pills. The final formulation was bright red and in fine powder form, which was later rolled into pills using
Nimbu Swarasa. The pills had a spicy taste, croton-like smell, and smooth texture, producing no sound when
touched. Physico-chemical parameters, along with instrumental analysis results, supported its potential antipyretic
activity.
REVITALIZING SKIN : A REVIEW ON TARUNYAPIDIKAHARA LEPA
Authors: Purohit Medha , Sharma Usha , Mitra Shuchi , Chand Sharma Khem
Published: December 2024

Skin is the first line of defence against external chemical and microbial threats, being the most exposed
organ to the external environment. It harbours a microbial habitat and varies considerably across the
body surface.1 Alongwith the several factors affecting skin integrity, the changing lifestyle patterns also
influence skin health. Ayurvedic classics enumerate many oral and topical formulations for various skin
conditions. Among them, one such topical formulation named Tarunyapidikahara Lepa has been studied
in this paper. An enhanced understanding of the properties of its ingredients is necessary to gain insight
into their way of functioning in dermal care and to enable novel therapeutic approaches for the same.
IMPACT OF COVID-19 ON DIAGNOSTIC ANALYSIS OF MYOCARDITIS
Authors: Hysenaj Klara , Qyra Shpetim , Stena Rezarta , Bani Blerina
Published: December 2024

Introduction: Myocarditis is a disease caused by inflammation of the heart muscle, the myocardium. The myo-cardium is responsible for contracting and relaxing to pump blood in and out of the heart and the rest of the body. When this muscle becomes inflamed, its ability to pump blood becomes less effective. This causes prob-lems such as abnormal heartbeat, chest pain, or breathing disorders. In extreme cases, it can also cause blood clots that lead to heart attack, stroke, and even death.
Purpose: To study the aggravating factors of COVID-19 that caused myocarditis and its prevention. Despite the distinctive clinical signs of patients with COVID-19, there are still elements that remain undiscovered, such as the prognostic factors of COVID-19, which include external factors, such as viral load and internal factors, which include the health conditions of the individual, the incidence rate of myocarditis and distinguishing signs.
Materials and Methods: This is a retrospective study highlighting the clinical and radiographic signs of the above cases diagnosed with COVID-19. Demographic, epidemiologic, radiologic, and laboratory data collected from medical record reviews of adult patients diagnosed with COVID-19 provided the basis for their follow-up. Measurement of the cycle threshold value (Ct), real-time PCR (RT-PCR), electrocardiogram (ECG), and meas-urement of pulmonary inflammation index (PII) values were among the most frequent examinations performed in these patients.
Results: In the study, 75 adult patients diagnosed with COVID-19 admitted to QSUNT were included, of which 15 cases were severe and 60 were in stable condition. The viral load of severe cases was significantly higher than that of stable patients, regardless of PCR values. Typical Ct abnormalities were more likely to exist in the severe group than in the non-severe group, associated with consolidation and thickening of the interlobular sep-tum and increased PII values. Of the 75 patients, 12 patients were noted to have an abnormal ECG and elevated serum myocardial enzyme levels, and five were clinically diagnosed with SARS-COV-2-induced myocarditis.
Conclusion: During the patient study, three independent risk factors of COVID-19 were identified, which in-cluded age, PII, and Ct value. The Ct value is closely related to the severity of COVID-19 and may act as a pre-dictor of the clinical severity of early-stage COVID-19. Oxygen pressure, along with laboratory tests, are ele-ments that should not be neglected as they are also closely related to the severity of COVID-19.
REVIEW ON TRIVIKRAMA RASA: A HERBOMINERAL FORMULATION FOR ASHMARI
Authors: Arya Anjali , Mitra Shuchi , Sharma Usha , Chand Sharma Khem
Published: December 2024

Trivikrama Rasa, a herbomineral formulation used in Ashmari, is the subject of this comprehensive review. The
term 'herbomineral' refers to a combination that contains both herbs and minerals as main ingredients. These
formulations have a longer shelf life than herbal formulations and when taken internally are more readily
absorbed because of the extensive trituration done during preparation. The manufacturing process includes
Shodhana (Purification), Mardana (Trituration), Marana (Incineration), and more. This article presents
Trivikrama Rasa and its likely modes of action using modern and Ayurvedic modalities. The review is
meticulously compiled from classical references, provides a reliable source of information. The available data is
presented systemically, offering a general introduction of ingredients, preparation method of formulation, dose
and its probable mode of action. Trivikrama Rasa has been reported in all classical texts as an effective means of
managing Ashmari quickly.
ANALYTICAL PROFILING OF KUPIPAKVA RASAYANA – A REVIEW
Authors: Reddy D Radhakrishna , Medikeri Surekha
Published: December 2024

Introduction: Though the Ayurvedic formulations are time tested for their promising and reliable therapeutic efficacy, there is a need for standardisation of the same in the current era to meet the global standards followed by global acceptance. A formulation must pass all the analytical tests before it enters the market, regardless of the system of medicine and dosage form, for the safe use of the drug. Analytical profiling in Kupipakva Ra-sayana (herbo-mineral preparations cooked in glass flasks under controlled heat) is essential for ensuring the safety, efficacy, and quality of these potent formulations used in Ayurveda, particularly Rasashastra. The com-plex processes and materials involved in Kupipakva Rasayana require a robust analytical assessment to validate their therapeutic use. Aim and Objectives: The study's main aim is to emphasise the importance of Analytical profiling in Kupipakva Rasayana. Materials and Methods: Concept of Kupipakva Rasayana, Instrumentation and SOP of each Analytical test for Kupipakva Rasayana, Impact of Analytical profiling in safety aspects, Need of Analytical profiling for Kupipakva Rasayana. Discussion: Though designing a formulation is the prime step in developing pharmaceutics, the analytical standardisation of the designed formulation encourages further prod-uct movement. Conclusion: Analytical profiling of Kupipakva Rasayana is essential because it decides the Pharmacodynamics and pharmacokinetics of the Drug thereby playing a significant role in therapeutic applica-tions
PHILOSOPHICAL AND PRACTICAL ASPECTS OF AYURVEDA AS DISCUSSED IN AGNIPURANA
Authors: Mithra JY Beena
Published: December 2024

Objectives
Ayurvedic blends our modern lifestyle and health-oriented habits with the ancient wisdom of using natural substances, medicines and herbs to help us lead a healthy, happy, stress-free, disease-free life. Ayurveda is the science of life. Ayurveda has two main goals. The first is to maintain the health of a healthy person by following
Dinacharya, Rithucharya, and Sathvrithi. Another is to treat diseases of the sick.,
Review Method Ayurveda in Puranas and Upapuranas a study
A CRITICAL REVIEW ON DANTODBHEDAGADANTAKA RASA
Authors: Anuja Samindar Pawar , Jithesh Chowta
Published: December 2024

Oral health is a good indicator of overall well-being and quality of life. The mouth is considered a window into the
health of the body because it is a gateway to the alimentary canal. Teething is a natural physiology and development
stage that all children experience and generally commences from 6 months to 3 years.
A recent literary review showed that the global prevalence of dental caries in primary teeth was 46.2% and for
permanent teeth 53.8%.
Aacharya Kashyapa has devised a complete description of Danta Shaarira, which is evidenced by the particular
chapter Dantajanmika Adhaya. He has detailed explanations about Dantajanma, Sakrutajata and Dwija danta, and
danta bheda.
Dantodbheda gadantaka rasa is an Ayurvedic medicine in the tablet form having predominantly katu-tikta rasa,
laghu-ruksha guna, ushna virya and katu Vipaka. It treats disorders such as jwara and Atisara during teeth eruption
in children.
AN AYURVEDIC APPROACH TO ARDITA (BELL’S PALSY): A CASE REPORT
Authors: K Chandana , Hullur Yaseen , A S Prashanth
Published: December 2024

Ardita (Bell's palsy) is considered as one of the 80 Vataja Nanatmaja Vyadhis in Ayurvedic classics. In modernday science, it could be correlated with the disorder of Unilateral facial paralysis. Bell’s palsy, additionally termed
as Idiopathic facial paralysis (IFP), is the common cause of unilateral facial paralysis. Facial palsy is a neurological ailment wherein the 7th cranial nerve gets affected. The facial nerve conveys sensory and motor fibres with
parasympathetic nerve fibres. Damaged facial nerve (VII) consequences are functional loss of facial muscle, resulting in facial impairment. The current study has been performed to discover the effective Ayurvedic management of Bell’s palsy in a 16-year-old male patient who approached Ayurveda Mahavidyalaya and Hospital, Hubballi. He was diagnosed with Ardita (Bell's palsy) – Left-sided Bell's Palsy and managed with
Karpasasthyadi taila mukhabhyanga(Facial oil massage),Panasa patra sweda(Jackfruit leaf sudation) followed
by nasya(nasal drops) with Ksheera bala taila 101 for 10days and confirmed well-sized development in the signs
and symptoms with no adverse effects. The house-Brackmann facial nerve grading system was used for the
patient's pre-test and post-test assessment.
Book review: Identity theory (2023) by Peter J. Burke and Jan E. Stets
Authors: Mohammed-Azizi Rym Lina
Published: December 2024

A book review of Identity theory (2023) by Peter J. Burke and Jan E. Stets
Identities at the dinner table: Commensality, self-perception, and relationships in Anne Cherian’s A Good Indian Wife
Authors: George Nayana
Published: December 2024

Food studies is rapidly gaining ground as a multidisciplinary area of research. Within it, literary food studies brings an interdisciplinary perspective as works of literature are viewed through the lens of food that is informed by frameworks and concepts that are rooted in a variety of fields including cultural anthropology, sociology, and more. One such concept that is in focus here is that of commensality that is associated with food and food practices. Commensality, drawing from notions of conviviality, refers to the practice of sharing a table and consuming food together. Deeper meanings of communal identities come to the fore in this social practice, leading it to shape how identities are understood and projected. Commensality can be a complex site of belonging and alienation depending on the context, and this paper seeks to explore the representation of the same in Anne Cherian’s A Good Indian Wife (2008). Leila, the titular Indian wife in the novel, moves to the US from India after her marriage to Neel and grapples with finding her place in the foreign land. With this displacement comes the endeavor to reaffirm her new identity, which now includes the role of being a wife and the aspect of being an immigrant. Neel also deals with complicated feelings towards the projection of his identity. With food playing a crucial role in the everyday experiences of their lives, commensality becomes a point of enquiry into how they see themselves and how their relationships with each other and themselves evolve through the course of the narrative.
Fantastic names and how to translate them
Authors: Stoyanova-Georgieva Irina
Published: December 2024

The current paper presents an empirical research that studies the approaches governing the process of transformation from English into Bulgarian of elements in the source text which are heavily loaded with culture, symbolism and meaning. More precisely, the article pays attention to the transformation of personal names, titles, names of fantastic beasts (animals), names of objects and institutions, as well as geographical names excerpted from a beloved companion book of the Harry Potter series. The study examines the source text of Fantastic Beasts and Where to Find Them and its Bulgarian translation mapping and describing the translator’s treatment of these items, discussing the effectiveness of the different procedures and the motivation for their application. In the pursuit of a leading approach which governed the translator’s decisions (to domesticate or to foreignize), the study reaches to the conclusion that in the majority of the cases it is not the decision to read the text as an original or as a translation that governs the choice of translation techniques but the function and the role of the different denominations in the text.
Unlocking the potential of willingness to communicate on the Clubhouse application: Insights from the Heuristic Pyramid Theory
Authors: Az Zahra Fatimah , Yappy Shierly Novalita , Widodo J. Priyanto
Published: December 2024

Despite the growing popularity of digital language learning platforms, understanding the intricacies of communication willingness within these contexts remains limited. This study addresses the gaps in understanding the dynamics of willingness to communicate (WTC) on the “Smart and Easy English” Clubhouse Application through the lens of the Heuristic Pyramid Theory. The study adopts a case study design with three participants and employs a questionnaire encompassing Motivational Propensities (MP), Affective and Cognitive Context (ACC), and Social and Individual Context (SIC), complemented by an interview. The findings reveal both positive and negative insights into the participants’ communication experiences on the platform, shedding light on the multifaceted nature of WTC. The positive results highlight enhanced confidence and motivation, while negative aspects point to challenges in affective and cognitive dimensions. These findings have significant implications for optimizing communication experiences on Clubhouse and similar platforms, emphasizing the need for tailored interventions to address individual and social factors influencing WTC. This study contributes valuable insights to the intersection of language learning, communication willingness, and digital platforms, paving the way for improved user experiences and educational outcomes on Clubhouse.
Exploring an Indonesian EFL teacher’s identity development: A story of hybridity in liminality
Authors: Prabandari Carla Sih , Adi Badiozaman Ida Fatimawati , Turner Kristina
Published: December 2024

The Indonesian programme of Pendidikan Profesi Guru (PPG) or the Teacher Professional Education (TPE) best describes a liminal space where its participants transform from uncertified status to certified ones. This paper uses the lens of liminality theory to explore the experience of an Indonesian in-service EFL (English as a Foreign Language) teacher’s identity reconstruction during a liminal period of TPE. The participant’s liminality made her adopt a new identity as a teacher-student hybrid in becoming a certified EFL teacher. In this single case study, the data were collected from two interviews with Olga (a pseudonym), her reflective writings and lesson plans, and video observations of the teaching practicum. The findings reveal that being a teacher-student hybrid, Olga performed multiple roles simultaneously: as a teacher, student and novice researcher. Olga faced various professional identity tensions during the programme. By exercising agency, Olga transformed tensions into learning experiences and benefited from her hybridity in that it afforded her an opportunity for self-development of learning, cognition, emotion and agency. Thus, this study offered a new way of understanding hybridity in liminality experienced by an EFL teacher while attending an online professional education. The article concludes with implications for educational policies and practices, suggesting the need for continuous support, integration of hybridity, adjustments in teacher training, addressing identity tensions, and conducting future research to enhance teacher development and effectiveness.
Exploring the impact of form and content feedback on EFL writing proficiency: A quasi-experimental study
Authors: Çiçek Mevlüde , Kayaoğlu Mustafa Naci
Published: December 2024

With process-oriented approaches becoming the norm in writing classes, teacher-written feedback has gained significance in teaching, learning, and educational research. As a result, writing instructors dedicate a considerable amount of time to providing feedback. However, research on the impact of written feedback from teachers has produced inconsistent findings regarding its effectiveness. The primary objective of this study is to examine the effects of feedback targeting form and content on the writing proficiency of English as a Foreign Language (EFL) students in areas of content, organisation, vocabulary, grammar, and mechanics. For this study, we used a quasi-experimental design. We formed two groups: an experimental group that received feedback focused on content and a control group that received feedback focused on form. We collected both qualitative and quantitative data through writing tests as well as semi-structured interviews. The results showed significant improvement in writing for both groups. Qualitative analysis revealed that students still view grammar as important, strive for accuracy, and may resist feedback regarding the communication of information in their writing.
Comparative analysis of color connotations across translated versions of the Holy Quran
Authors: Almahasees Zakaryia , Albudairi Yousef
Published: December 2024

The Noble Quran, a rich source of color symbolism, uses colors to address various aspects of human existence and life after death. These colors convey positive and negative undertones, aesthetic or moral lessons, and symbolic implications. This paper compares the color connotations across the various translations of the Holy Quran; it shows how the linguistic and cultural differences hint at the varied interpretations that may differ in presenting the symbolic meanings or theological concepts to readers. This study delves into the intricate world of translation strategies, examining the approaches of four prominent translators in rendering the nuanced connotations of colors into English. The study compiled a corpus of Colors in the Holy Quran from Pickthall (1930) and Sahih International (1997) translations, representing Muslim Translation and non-Muslim translations by Arberry (1955) and Dawood (2014). The study highlighted the frequency of explicit colors in the Holy Quran and compared the four translations and the strategies used in rendering the connotations of colors. The study addressed the following question: How do different translation strategies impact Muslim and non-Muslim translators' rendering of color symbolism in the Noble Quran? It was found that white is the most frequent color, followed by green, black, yellow, blue, and red. Translators employed literal translation, addition, free translation, domestication, and omission. The study also revealed an intertextual reference to the Old Testament in Dawood's translation, adding another layer of complexity to the analysis. This paper contributes to understanding how translation strategies, including literal translation, domestication, and intertextual references, influence interpretation related to color symbolism in the Quran and bring cultural and religious nuance to the text.
The Role of Gender Norms in Shaping Political Leadership: A Critical Analysis on Bangladesh Perspective
Authors: Aziz, PhD M.M. Enamul
Published: December 2024

Gender norms play a crucial role in shaping the dynamics of political leadership across the world. This study examines the role of gender norms in shaping political leadership in Bangladesh, focusing on the representation and participation of women in political institutions, the challenges posed by gender norms, the impact of gender equality policies, and the comparison of leadership styles between male and female leaders. Using a qualitative approach, the study relied on secondary data sources, including policy reports, academic literature, and historical documents. The analysis focuses on content analysis of the evolution of gender norms and their impact on political leadership, as well as the effectiveness of gender equality initiatives. The findings reveal that, despite progress in women’s representation, traditional patriarchal norms continue to limit women’s full participation in political leadership. Male leaders typically adopt an authoritative, transactional leadership style, emphasizing power and control, whereas female leaders tend toward a more inclusive, transformational style, focusing on social welfare and long-term policy planning. women face significant barriers, including societal scrutiny and the expectation to conform to both leadership and traditional gender roles. Gender equality policies, while present, have had limited impact due to deeply rooted societal norms and structural challenges. This study highlights the need for more effective policies and initiatives to address these gender-based barriers, encouraging a more inclusive political landscape and contributes to the broader discourse on gender and leadership, offering insights into how gender norms shape political leadership in developing countries like Bangladesh.
Validation and Reliability of the Revised Manipal Inventory of Academic Stress (MIAS) among Higher Secondary Students in Karnataka, India
Authors: Ramesh Anirudh , Sureshramana Mayya Shreemathi , Martis Maxie , Mayya Arun
Published: December 2024

The Manipal Inventory of Academic Stress (MIAS) is designed to assess academic stress among higher secondary students in Karnataka, India. This study aims to validate an updated version of the MIAS, refined to an 18-item scale from its original 19-item format. A cross-sectional survey was conducted among 533 students (189 males and 344 females) from commerce and science streams. Exploratory and confirmatory factor analyses supported a unidimensional model of the MIAS, explaining 40.3% of the variance. The MIAS demonstrated high internal consistency (Cronbach’s alpha = 0.923) and significant positive correlations with the Perceived Stress Scale (r= 0.789, p<0.001) and the stress subscale of the Depression Anxiety Stress Scales-21(r=0.707, p<0.001), along with a negative correlation with the Rosenberg Self-Esteem Scale (r=-0.751), indicating good concurrent and convergent validity. These findings underscore the MIAS’s efficacy as a screening tool for academic stress in the Indian educational context. Its application can facilitate timely interventions, such as counseling or stress management programs, potentially mitigating adverse mental health outcomes in this demographic.
Sexual Identity Development of Sexual-and-Gender Minority Among Malay Women in Malaysia
Authors: Syed Jaapar Sharifah Zubaidiah , Muhamad Rosediani , Ab Razak Asrenee , Bakar Mujahid , Mokhtar Rafidah Hanim , Ishak Azlina
Published: December 2024

Understanding the sexual identity development of the sexual and gender minority among Malay women (SGMMW) is necessary for providing them with appropriate services. However, owing to a paucity of studies on this subject, the present study thus explores the sexual identity development of SGMMW. A phenomenology study was performed on 30 SGMMW. In-depth, semi-guided virtual interviews were conducted, each lasting 45–90 min. Recordings of the interviews were transcribed verbatim. Subsequently, all transcriptions were added to ATLAS.ti 8 for analysis and coding. Three themes were elucidated from the study: awareness of incongruence, exploration of self-identity, and consolidation in the L Community. These three themes represent three phases of the sexual identity development of SGMMW. In Phase 1, SGMMW becomes aware of their sexual orientation toward females. In Phase 2, SGMMW explored information, community, and partners that could affirm their identities. In Phase 3, SGMMW consolidated itself into a new community that aligned with its new identity, also known as the L Community. Sexual identity development is influenced by environmental factors such as family, friends, institutions, and social media; personal factors such as a belief that men are bad; and behavioral factors such as behaving like a man to protect the self and others. In conclusion, SGMMW identity development involves three phases and is influenced by environmental, personal, and behavioral factors.
Swiftlet Farming Industry—A White Gold in the Malaysian Housing Market?
Authors: Adi Maimun Nurul Hana , Choon Yeong Ka
Published: December 2024

The swiftlet farming industry is fast-growing and contributes to Malaysia’s economic growth. Nonetheless, dirty and noisy surroundings caused by bird droppings and audio systems are unattractive and may adversely impact the housing market. Hence, this study seeks to ascertain the price impacts of the swiftlet farming industry. The first objective defines the hedonic model by reviewing its definition, theoretical framework, methodological process, and house price applications. The second objective explores factors influencing house prices, including the animal farming industry, through a literature review. The third objective evaluates the impact of the swiftlet farming industry on house prices. Ten-year house transaction data and spatial data provided by the Valuation and Property Services Department and Municipal District of Bentong are used to construct the Hedonic model. The result is evaluated based on its logical, statistical and predictive performance. The study found that swiftlet farming in Bentong has a negative impact on house prices, with an inverse price impact that increases with distance from the farming area. Buyers are reluctant to pay for houses near farming due to noise pollution and obstruction. This study supports international and national agendas relating to environment and health sustainability.