bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Dividend Payout Ratio, Firm Size, dan Corporate Social Responsibility terhadap Price Book Value Pada Perusahaan Subsektor Food And Beverage yang Terdaftar di BEI Periode 2018-2023
Authors: Evitrah Faza Maulia , Hasanudin Hasanudin
Published: January 2025

Tujuan penelitian ini untuk mengetahui pengaruh Dividend Payout Ratio, Firm Size, dan Corporate Social Responsibility terhadap price book value pada perusahaan subsektor food and beverage yang terdaftar di BEI periode 2018-2023. Metode yang digunakan dalam penilitian ini adalah metode kuantitatif. Teknik pengambilan sampel menggunakan purposive sampling dan diperoleh 11 perusahaan sebagai sampel penelitian. Penelitian ini dilakukan pada periode 2018-2023 sehingga diperoleh data observasi sebanyak 66 data observasi. Metode anlisis yang digunakan yaitu uji regresi data panel. Hasil penelitian menunjukkan bahwa Dividend Payout Ratio secara parsial tidak berpengaruh signifikan terhadap Price Book Value dengan nilai t-hitung sebesar -0,857088 < 1,99897 dengan nilai signifikansi  0,3953  > 0,05. Firm Size secara parsial berpengaruh negatif dan  signifikan terhadap Price Book Value dengan nilai t-hitung sebesar -3,587656 > 1,99897 dengan nilai signifikansi 0,0007  > 0,05. Corporate Social Responsibility tidak berpengaruh signifikan terhadap Price Book Value dengan nilai t-hitung sebesar -1,195581 < 1,99897 dengan nilai signifikansi 0,2373 > 0,05. Berdasarkan pengujian secara simultan Dividend Payout Ratio, Firm Size , dan Corporate Social Responsibility secara simultan berpengaruh signifikan terhadap Price Book Value dengan nilai F-hitung sebesar 23,60896 > 2,75 dan tingkat signifikansi sebesar 0.00000 < 0,05.
Enhancing NVMe SSD Performance through Intelligent Data Placement: An Analysis of Implementation and Benefits
Authors: Kasthuri Theja Peduru
Published: January 2025

Storage systems increasingly rely on NVMe SSDs for their superior performance characteristics, yet traditional static data placement strategies often fail to leverage their capabilities across diverse application workloads fully. This article comprehensively analyzes application-aware data placement in NVMe SSDs, exploring how workload-specific optimization can enhance storage performance. The core components of this article include workload characterization through read/write pattern analysis, strategic data placement optimization for both hot and cold data, and dynamic adaptation mechanisms for evolving workloads. This article addresses key implementation challenges such as processing overhead, protocol compatibility, and system scalability while highlighting potential benefits including improved I/O performance, reduced latency, and enhanced resource utilization. This article suggests that application-aware data placement represents a promising direction for optimizing NVMe SSD performance. However, careful consideration must be given to practical implementation constraints within existing NVMe standards and protocols.
Nível de endividamento das famílias agricultoras de Juta e Malva da zona rural da microrregião de Manaus: o caso de Manacapuru no Amazonas
Authors: Carvalho Débora da Costa , Almeida Neuler André Soares de
Published: January 2025

Nosso país sempre contou com as atividades agrícolas em sua economia, a exportação de commodities é uma grande geradora de renda, e em nosso Estado, que apresenta grandes recursos naturais, a realidade não é diferente. A produção agrícola é responsável pelo sustento de quase todas as famílias da Zona Rural do Amazonas e, nas áreas de várzea, se destacam dois produtos: a juta e a malva. Mas essa atividade continua com as mesmas técnicas de execução arcaicas desde quando se iniciou em nosso estado, há mais de oitenta anos. Além disso, surgiram produtos concorrentes com maior produtividade, o que encareceu os rendimentos e a produção – que é afetado também pelas condições climáticas, comprometendo a renda das famílias que dependem dessa atividade e elevando o seu nível de endividamento. Esta pesquisa avaliou o quanto a queda nesse mercado influenciou o nível de endividamento dessas famílias, tomando por base o caso de famílias em uma comunidade do interior de Manacapuru, onde a maior parte da renda é proporcionada por esses dois produtos. Os procedimentos metodológicos levaram em conta a realização de entrevistas e a aplicação de questionários em uma amostra de mais de 20 famílias. Os resultados obtidos mostram que cerca de um terço dessas famílias possuem entre 61 e 90% da sua renda comprometidos com dívidas, e 60% das famílias se consideram muito endividadas, além de um aumento na inadimplência junto a órgãos de fomento da ordem de 60%, segundo nossas estimativas, o que comprova a hipótese inicial da pesquisa.
ЗАГАЛЬНИЙ ІННОВАЦІЙНИЙ МЕХАНІЗМ УПРАВЛІННЯ ЕФЕКТИВНІСТЮ ДІЯЛЬНОСТІ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: Харенко Дмитро , Левченко Сергій
Published: January 2025

У статті описані деякі аспекти, які є важливими у контексті функціонування закладів вищої освіти – а саме поняття вимірювання ефективності, яке може бути необ’єктивним показником ефективності, якщо буде підпадати під дії закону Кемпбелла та Гудхарта, в результаті яких заклад вищої освіти (ЗВО) буде прагнути досягти саме формальних показників ефективності замість реальних. Також, у статті обґрунтовано важливість інноваційної діяльності у контексті ефективності діяльності ЗВО, оскільки вона дає додаткові конкурентні переваги та джерела для фінансування. На основі цього, у статті запропонований загальний механізм управління інноваційною діяльністю ЗВО. Також, у статті розглянуто інноваційний механізм протидії спротиву до змін, метою якого є покращення комунікацій в ЗВО шляхом активного залучення та роз’яснення необхідності змін.
The Craft of Poetry: A Stylistic Study of Jamal Assadi's Verse
Authors: Nassim Assadi
Published: January 2025

This article provides a detailed analysis of the stylistic features in thirteen selected poems by Professor Jamal Assadi . Through an examination of both phonetic and syntactic structures, the study identifies key elements such as external and internal rhythm, rhyme patterns, repetition, alliteration, and antithesis, which contribute to the musicality and flow of Assadi’s poetry. The article explores various grammatical elements, such as vocative expressions, imperatives, hyperbole, and techniques for emphasis, which amplify the emotional and expressive impact of the poems. Additionally, it emphasizes Assadi’s skillful incorporation of metaphor, simile, and symbolism, illustrating how these literary devices enrich his poetry with layers of meaning and nuance. The study also examines the interplay between classical Arabic poetic structures and contemporary themes, highlighting the harmony he achieves between tradition and modernity, this article offers valuable insights into what distinguishes Assadi’s poetic voice and contributes to the broader understanding of contemporary Arabic poetry.
PROMOTING SUSTAINABLE TEACHER DEVELOPMENT: THE IMPACT OF ONLINE LESSON STUDIES ON REFLECTIVE PRACTICES
Authors: Sasaya Takayoshi , Isshiki Reiko , Nawanidbumrung Witchayada
Published: January 2025

Reflective practice is essential in teacher education, enabling pre-service teachers to engage in meaningful professional development and continuously improve their teaching skills. However, barriers such as time constraints, geographic isolation, and crises like COVID-19 often hinder consistent engagement in reflective practices. This study developed and evaluated an online lesson study platform within a university-based teacher education program to address these challenges and support pre-service teachers’ professional growth. Using a mixed-methods approach, the study analyzed reflective engagement among 115 pre-service teachers in the Faculty of Education through reflection reports and surveys. The theoretical framework, based on Darling-Hammond’s reflective perspective, focused on student learning processes, teaching effectiveness, classroom atmosphere, personal educational philosophy, and continuous growth through reflective dialogue. Qualitative analysis revealed varying levels of engagement in reflective practices, with significant improvements in reflections on teaching methods and student learning. However, challenges remained in reflecting on students’ cognitive processes. Quantitative analysis using the McNemar test confirmed statistically significant increases in reflective practice engagement. These findings suggested that online lesson study platforms can provide accessible and practical opportunities for pre-service teacher professional development, overcoming barriers related to location and logistics and supporting global educational goals, particularly Sustainable Development Goals 4 (Quality Education) and 10 (Reduced Inequalities).
Keywords: lesson study, peer collaboration, professional development, reflective practices, teacher education
Time budgets of employees in different countries: structure, dynamics, new ratios of time expenditures
Authors: Minat Valerij N.
Published: January 2025

The stated problem of changes in spending the time budget of a modern economically active person is relevant in terms of the relationship between work and rest time through the dynamics and structure of time expenditures, which determines the quality of the human potential of the national economic system. Using national statistical groupings of a number of countries having the prominent positions in the cluster of high-tech industries, with the help of traditional methods of correlation analysis, some new ratios of time expenditures were revealed, distinguished by optimality in the structure and dynamics of spending the time budget of workers in the context of specific sections. General trends and differences of the compared countries in time budget sections, the share of time spent on work; non-working time associated with work; free time and leisure time of employees of high-tech cluster companies are shown. Particular attention is paid to the mutual influence of the division of the time budget of different countries, which is determined by fluctuations in time expenditures in the matrix of paired correlation coefficients. The results obtained reflect the influence of technologization and value socio-cultural transformation of workers in the studied cluster of economic sectors of the compared countries on the dynamics and structure of time budget spending, which reflects the change in social relations in the context of changing social structures.
PENGEMBANGAN BUKU SAKU MATEMATIKA MENGGUNAKAN PjBL UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIS SISWA
Authors: Solisa Tazkia Aulia Cahya , Syafmen Wardi , Kumalasari Ade
Published: January 2025

Kemampuan pemecahan masalah matematis di Indonesia masih tergolong rendah, hal ini dapat dilihat melalui hasil survey PISA dan TIMSS bahwa Indonesia tingkat kemampuan pemecahan masalah matematis peserta didiknya rendah. Upaya meningkatkan kemampuan pemecahan masalah matematis siswa dapat dilakukan melalui penggunaan buku saku matematika menggunakan PjBL untuk meningkatkan kemampuan pemecahan masalah matematis yang ditinjau dari kevalidan, kepraktisan, dan efektivitas. Penelitian ini menggunakan metode Resarch and Development dengan model ADDIE (Analysis, Desaign, Development, Implementation, and Evaluation). Ha yang diperoleh pada aspek kevalidan diperoleh penilaian validasi oleh ahli materi adalah 80% dengan kategori “sangat valid”, serta hasil validasi desain diperoleh adalah 90,6% dengan kategori “sangat valid”. Pada aspek kepraktisan, adapun perolehan nilai dari respon guru adalah 94,78% dengan kategori “sangat praktis”. Adapun hasil dari uji coba kelompok kecil terhadap Buku Saku Matematika yang dikembangkan adalah 90,37% dengan kategori “sangat praktis”. Pada aspek efektivitas perolehan nilainya sebesar 89,6% dengan kategori “sangat efektif”. Selanjutnya pada tes kemampuan pemecahan masalah matematis yang diberikan berupa pretest dan posttest didapatkan hasil dari uji N-Gain adalah nilai N-Gain dari semua siswa adalah sebesar 0,635 dengan kategori “sedang”.
IMPLEMENTASI MODEL PROBLEM BASED LEARNING UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA PESERTA DIDIK KELAS IV
Authors: Ayuningtyas Syafira Karenina , Damayanti Aries Tika , Wigati Trinil , Suyoto Suyoto
Published: January 2025

Pembelajaran belum berpusat pada peserta didik. Peserta didik kesulitan dalam mengidentifikasi masalah dan menghubungkan dengan konsep matematika, sehingga hasil belajar matematika rendah. Penelitian tindakan kelas ini bertujuan untuk meningkatkan hasil belajar peserta didik melalui implementasi model problem based learning pada mata pelajaran matematika. Penelitian dilakukan dalam dua siklus, setiap siklus terdiri dari tahap perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian ini adalah 29 peserta didik kelas IV SD Negeri Panggung Lor Semarang, yang terdiri dari 12 perempuan dan 17 laki-laki. Objek penelitian ini adalah hasil belajar matematika peserta didik. Data hasil belajar dianalisis menggunakan statistik deskriptif kuantitatif. Data hasil belajar matematika peserta didik kelas IV ketika pra siklus menunjukkan rata-rata 62,9 dengan persentase ketuntasan sebesar 41,4%, pada kategori sedang. Pada siklus I menunjukan rata-rata 71,2 dengan persentase ketuntasan sebesar 55,2%, pada kategori sedang. Sedangkan pada siklus II menunjukkan rata-rata 76,7 dengan persentase ketuntasan sebesar 79,3%, pada kategori tinggi. Jadi dapat disimpulkan bahwa model problem based learning dapat meningkatkan hasil belajar matematika peserta didik kelas IV.
PENGEMBANGAN MEDIA APLIKASI TRIMATH DENGAN PENDEKATAN CTL (CONTEXTUAL TEACHING AND LEARNING) PADA MATERI TRIGONOMETRI
Authors: Eriyan Deni , Yazidah Nok Izatul
Published: January 2025

Penelitian ini dilatarbelakangi oleh kurang efektifnya pembelajaran matematika di kelas X MA Al Hidayah Wajak dimana proses pembelajaran yang mayoritas masih menggunakan teknik pengajaran konvensional yang hanya mengandalkan buku teks dan papan tulis sehinhgga kurang memotivasi siswa, sering kali siswa merasa jenuh dan bosan ketika belajar matematika. Kurangnya media pembelajaran yang digunakan didalam kelas juga menjadi salah satu faktor kurangnya motivasi belajar siswa. Selain itu juga didukung oleh faktor SDM guru pengajar, dimana guru yang mengajar matematka termasuk guru senior namun terkesan jadul karena selain faktor usia juga lulusan sudah lama sehingga kebanyakan dari mereka kurang menguasai IT. Dengan demikian peneliti melakukan penelitian ini bertujuan untuk mendeskripsikan media aplikasi Trimath dengan pendekatan CTL (Contextual Teaching and Learning) pada materi trigonometri yang valid, praktis, dan efektif yang dapat digunakan untuk menunjang pembelajaran di dalam kelas. Peneliti menggunakan model pengembangan ADDIE dengan lima tahapan yaitu: analysis (analisis kebutuhan dan analisis kerja), design (desain produk), development (pengembangan produk), implementation (implementasi produk dengan uji coba kelompok kecil dan kelompok besar), dan evaluation (mengevaluasi produk).  Pada tahap implementasi semua rancangan media yang telah dikembangkan diterapkan setelah dilakukan revisi. Dengan melakukan uji coba kelompok kecil pada 7 siswa kelas X-2 MA-Al Hidayah Wajak dan uji coba kelompok besar pada 15 siswa kelas X-2 MA-Al Hidayah Wajak. Berdasarkan uji tanggapan peserta didik pada uji coba kelompok kecil diperoleh bahwa produk media aplikasi Trimath dengan pendekatan CTL pada materi trigonometri mendapatkan kategori layak dengan persentase sebesar 76%. Sedangkan hasil tanggapan peserta didik pada uji coba kelompok besar diperoleh bahwa produk media aplikasi Trimath dengan pendekatan CTL pada materi trigonometri sangat layak dengan persentase 85%.
EKSPLORASI PEWARNAAN GRAF DALAM IDENTIFIKASI DESTINASI KULINER MENGGUNAKAN ALGORITMA WELCH POWELL DI KOTA SERANG
Authors: Lubis Hirawati , Nuraini Siti
Published: January 2025

Kuliner menjadi salah satu daya tarik utama bagi wisatawan saat mengunjungi suatu daerah dan merupakan elemen penting dari pengalaman wisata. Setiap daerah menawarkan beragam pilihan kuliner, mulai dari hidangan tradisional hingga variasi modern. Namun, banyaknya pilihan sering kali membuat wisatawan kesulitan menentukan destinasi kuliner yang tepat. Oleh karena itu, diperlukan metode yang dapat membantu dalam pemilihan makanan dan tempat makan secara efisien. Penelitian ini menerapkan metode pewarnaan graf dengan menggunakan algoritma Welch-Powell untuk mempermudah identifikasi dan pemetaan destinasi kuliner. Algoritma ini akan Menghasilkan bilangan kromatik yaitu memberikan warna pada simpul-simpul graf  untuk merepresentasikan tempat makan yang tidak terhubung, sehingga mempermudah analisis keterkaitan dan struktur antar destinasi. Penerapan metode ini diharapkan dapat memberikan wawasan eksplorasi pewarnaan graf tentang pola kunjungan kuliner dan mendukung pengembangan strategi pariwisata kuliner yang lebih efektif dan berkelanjutan.
PENGEMBANGAN MEDIA PEMBELAJARAN STORYBOARD PADA MATERI BANGUN DATAR MATEMATIKA SD
Authors: Jusniani Nia , Monariska Erma , Rosdianti Neneng Kartika , Lestari Resti
Published: January 2025

Kurangnya penggunaan alat bantu konkret atau media manipulatif dalam pembelajaran matematika merupakan masalah yang sering muncul dalam pembelajaran. Penggunaan media visual atau alat manipulatif seperti geoboard, balok geometri, atau potongan kertas dapat membantu siswa membangun pemahaman spasial yang lebih baik. Penelitian ini menggunakan pendekatan kualitatif. Penelitian ini berfokus pada proses pengembangan media Storyboard yang digunakan untuk mengajarkan bangun datar di SD. Tujuan utamanya adalah untuk merancang, mengembangkan, dan menguji keefektifan media pembelajaran tersebut. Penggunaan storyboard dalam pembelajaran matematika terbukti efektif dalam meningkatkan pemahaman siswa terhadap konsep-konsep matematika yang abstrak. Storyboard dapat menjadi salah satu alat yang efektif dalam membantu siswa belajar matematika secara interaktif dan aplikatif, meningkatkan keterampilan berpikir kritis dan pemecahan masalah matematis.
MAKAM ADIPATI WIRASABA DALAM PERSPEKTIF ETNOMATEMATIKA
Authors: Fertikawati Ratna , Kusno Kusno
Published: January 2025

Makam Adipati Wirasaba adalah cagar budaya yang berlokasi didesa WIrasaba di kabupaten Purbalingga yang selama ini dimanfaatkan oleh masyarakat sekitar sebagai tempat wisata religi dan sejarah. Pelaksanaan penelitian ini memiliki tujuan menguraikan objek – objek matematika yang ada pada makam Adipati Wirasaba. Penelitian ini adalah studi kualitatif yang mengaplikasikan pendekatan etnografi. Dalam menganalisis data yang digunakan adalah analisis deskriptif model Miles dan Huberman yaitu pengumpulan data dari berbagai sumber (wawancara, observasi dan dokumen), reduksi data dengan cara menyaring dan mengolah data untuk menekankan informasi yang penting, menyajikan data dalam format yang mudah dimengerti, serta menarik kesimpulan dengan cara menginterpretasikan data dan membuat kesimpulan berdasarkan analisis yang dilaksanakan. Objek dalam penelitian ini adalah artefak – artefak yang ada pada makam Adipati Wirasaba, sedangkan subjek dalam penelitian ini adalah juru kunci makam dan masyarakat sekitar. Penelitian ini memberikan hasil bahwa terdapat berbagai artefak di makam Adipati Wirasaba yang merupakan situs cagar budaya antara lain nisan makam, hiasan kaligrafi, hiasan plafon, tiang bangunan utama, bagian atap, papan informasi, lipatan pada tiang, pagar utama dan lantai yang menerapkan konsep matematika seperti bentuk persegi, persegi panjang, segitiga sama sisi, trapesium, lingkaran, sektor, bentuk kubus, balok, limas dan transformasi geometri (refleksi dan dilatasi).
PENERAPAN MODEL PEMBELAJARAN TGT BERBANTUAN BAAMBOOZLE UNTUK MENINGKATKAN KEMAMPUAN PEMAHAMAN DAN SELF CONFIDENCE SISWA
Authors: Nisa Miftahul , Musriandi Riki , Aryani Irma
Published: January 2025

Penelitian ini bertujuan untuk mengetahui Peningkatan kemampuan pemahaman  dan self confidence siswa yang diajarkan mengunakan model pembelajaran Teams Games Tournament (TGT) dengan berbantuan Baamboozle, juga untuk mengetahui perbedaan peningkatan kemampuan pemahaman dan perbedaan peningkatan self confidence siswa dengan menggunakan model pembelajaran Teams Games Tournament  berbantuan Baamboozle dengan model pembelajaran konvensional. Jenis penelitian yang digunakan adalah kuantitatif dengan metode Quasi Eksperimen  dengan desain two group pre-test dan post-test. Populasi terdiri dari 81 siswa, sampel dalam penelitian ini siswa kelas VIII A dan VIII B SMP Negeri 2 Ingin Jaya, kabupaten Aceh Besar. Sampel dipilih dengan teknik Purposive Sampling, dimana sampel pada penelitian ini dipilih oleh guru disekolah sesuai dengan kebutuhan peneliti. Hasil penelitian menunjukkan adanya perbedaan peningkatan kemampuan pemahaman dan self confidence siswa dengan menggunakan model pembelajaran Kooperatif Tipe Teams Games Tournament  berbantuan Baamboozle dibandingkan dengan menggunakan model konvensional, hal ini dibuktikan dengan hasil uji independent Sampel t-test yang memperoleh nilai signifikan 0,05. kemampuan pemahaman siswa dengan menggunakan Model Pembelajaran Teams Games Tournament berbantuan Baamboozle meningkat signifikan dengan nilai N-Gain = 0,7, dan terdapat peningkatan self confidence siswa dengan menggunakan Model Pembelajaran Teams Games Tournament berbantuan Baamboozle walaupun tidak signifikan dengan nilai N-Gain 0,4 0,7.
A utilização de ferramentas da qualidade no desenvolvimento do projeto terapêutico singular psicomotor de crianças com autismo: Uma revisão sistemática
Authors: Oliveira Laís Pereira de , Hékis Hélio Roberto , Almeida Mariana Rodrigues de , Lira Neto Roberto Eider , Araújo Ranih Pegado de , Montenegro Adriane Chaves Lima
Published: January 2025

Em um cenário global em que o Transtorno do Espectro Autista (TEA) consiste em um imperativo clínico e social o qual necessita de novas estratégias para intervenções terapêuticas de crianças, destaca-se a psicomotricidade como importante aliada na promoção do desenvolvimento motor e na melhoria da comunicação e interação social. Contudo, estudos mostram a falta de ferramentas determinísticas na elaboração do Projeto Terapêutico Singular (PTS) durante os tratamentos. Considerando o conhecimento em engenharia da qualidade e do uso de suas ferramentas no âmbito da saúde, com destaque ao ciclo PDCA, a Failure Mode and Effect Analysis (FMEA), a Matriz GUT e a 5w1h, este estudo tem como objetivo investigar a interseção entre as ferramentas da qualidade, psicomotricidade e o autismo, através de uma revisão sistemática da literatura. Utilizou-se as bases de dados scopus e pubmed para buscar artigos utilizando as palavras-chave “autismo”, “ferramentas da qualidade”, “psicomotricidade”, entre outras variantes. Os resultados revelam baixos indicadores de publicações sobre a temática principalmente no Brasil revelando um campo pioneiro para pesquisas futuras de aplicação dentro desse assunto.
Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men.
Authors: Šulcová J , Hill M , Hampl R , Mašek Z , Nováček A , Češka R , Stárka L
Published: January 2025

In order to ascertain the kinetics of absorption and metabolism of transdermally administered dehydroepiandrosterone (DHEA), 10 men 29-72 years old (mean 52.4±14.5) received 50 mg DHEA/day in a gel applied onto the skin of the abdomen for 5 consecutive days. The objective was to establish the extent to which DHEA influences the levels of gonadotropins, sex hormone-binding globulin and lipids. It was found that DHEA is well absorbed and rapidly metabolized to its sulfate (DHEAS), androstenedione, and consequently to testosterone and estradiol. The DHEA levels that markedly increased after the first doses gradually declined already during the application, and this decline proceeded even after it was discontinued, reaching levels significantly lower than the original ones. On the other hand, the levels of DHEA metabolites (with the exception of DHEAS) rose during the application and reached values significantly higher than the basal ones within 5 weeks. This effect was accompanied by significantly decreased levels of LH. The serum levels of lipids, namely of cholesterol (both HDL and LDL cholesterol), triglycerides, apolipoproteins A-I and B and lipoprotein(a) after DHEA application were not changed significantly, and the atherogenic index (AI) remained unaltered. However, some correlations between hormones and lipids were found. Negative correlations concerned the following indices: DHEA/Lp(a); DHEAS/cholesterol; DHEA, DHEAS, testosterone/TG; testosterone/AI. On the other hand, LH, FSH/cholesterol, FSH, SHBG/LDL cholesterol, FSH/Apo B, Lp(a) correlated positively. It can be concluded that transdermal short-time application of DHEA results in a decrease of endogenous DHEA after finishing the treatment, with a parallel marked increase in the levels of sex hormones. Using this application protocol, exogenous DHEA neither altered the lipid spectrum, nor did it influence the atherogenic index.
Stesys2: extended Stesys software for MS Windows.
Authors: Tomori Z , Matis L , Karen P , Kubínová L , Krekule I
Published: January 2025

The STESYS2 software is a new version of the IBM PC software supporting interactive stereological measurements. In comparison with the previous STESYS, it is enhanced by a number of useful options, e.g. on-line image input via a TV camera coupled with a microscope operating under MS Windows OS. The main advantage, when compared with other such software packages, is the design of the STESYS2 as a module of the freeware image processing system Image Tool which provides a user-friendly environment including a number of image processing and preprocessing routines. Capabilities of the STESYS2 are illustrated by a practical example: estimation of the surface area of capillaries in the terminal villi of human placenta by the Sandau spatial grid method.
What Am I Reading? How Teaching Genre Improves Civic Skills
Authors: Knutson Katherine , Flynn Rachel
Published: January 2025

This paper explores an effort to improve information literacy within an undergraduate political science course by teaching students about the related concepts of genre and rhetorical context (purpose, audience, and context), how to look for the subtle cues that indicate genre, and how to identify the genre and rhetorical context of the things they read and use as sources in their own work. Assessment data is used to explore the impact of this type of pedagogical intervention. We argue that the ability to notice, identify, and interpret the genre of various texts is an important component of information literacy, which contributes to the development of civic skills.
National Commissariat of Automobile Transport in 1941—1943
Authors:   Russian University of Transport (MIIT), Moscow, Russia, Medvedev Sergey V.
Published: January 2025

Introduction. The article deals with the activities of the People's Commissariat of Automobile Transport in the early years of the Great Patriotic War. The source base of the study was the orders of the People's Commissar of Automobile Transport A. N. Kurshev, transcripts of meetings of the board of the Commissariat, statistical information. Methods. The work was carried out using the following methods: retrospective and content analysis. Results and Discussion. As a result of
the study it was revealed that the solution of problems of wartime road
transport was characterized by extensive nature. The planned indicators
for equipping cars with gas-generator units, production and transportation of car parts, repair of trucks and cars were not fulfilled. Under the
conditions of acute shortage of cargo vehicles, some trusts of the People's Commissariat did not ensure the safety of vehicles under repair.
The management of automobile transportation for A. N. Kurshev was
complicated by a conflict with the head of the trust “Rosavtoglavsnab”
subordinate to the People's Commissariat, who was fired a few months
after the beginning of the Great Patriotic War. At the same time, the leadership of the People's Commissariat of Automobile Transport ensured
the commissioning of new workshops, organized the active sale of
gas-generator units, and encouraged the employees of the best automobile repair plants with bonuses. If in 1941 some motor transport offices
had absolutely no gasoline, in 1942 and 1943 such situations occurred
much less frequently. The trusts of the People's Commissariat “GARO”
and “Rosavtoremont”, which caused dissatisfaction of the Commissar in
1941-1942, in 1943 qualitatively improved the realization of planned indicators. The article also analyzes the “human dimension” of the research
topic. In addition to the already mentioned awards, one can note the
Commissar's concern for female employees of the Commissariat who
had children under 8 years of age (they were not called for the collection
and transportation of firewood), as well as the desire not to involve teenagers in the work of automobile departments. Conclusion. The work of
the NCAT trusts was evaluated according to the criteria of compliance
with the planned indicators. The management of the National Commissariat of Automobile Transport encouraged the initiative of rationalization proposals in conditions of resource shortage. The bottleneck in the
direction of NCAT activity remained automobile repair. Many automobile
departments and repair stations subordinated to the NCAT carried out
their activities in close proximity to the front line.
The Great Siberian Route: the Origins and Progress of the Russian Empire's Last Construction Project
Authors:   Russian University of Transport, Moscow, Russia, Cherepanov Vsevolod D.
Published: January 2025

Introduction. The article contains an assessment of the significance and
prospects of the Trans-Siberian Railway given by the President of the
Russian Federation Putin, reveals the main reasons for the start of construction, its geopolitical, socio-economic and cultural necessity, shows
the historical significance of the construction. Methods. The applied general scientific and special historical methods are briefly presented in
a systemic methodological context. Results and Discussion. The main
part, showing in detail the author's view and assessment of the objective and subjective reasons for the start of construction of the Great
Siberian Route, its course emphasizing the importance of the personal
contribution of all those involved in the birth of the colossal transport
infrastructure project — from the emperor and the crown prince, statesmen who held ministerial and other posts, to engineers and other direct
creators of the transport railway artery between the two parts of the
world. Conclusion. Contains conclusions about the political, social and
economic significance of the colossal, last construction project of the
empire, completed several months before the collapse of the country.
Its role in the present and future of modern Russia is indicated.
GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells
Authors: Ito Fumiya , Iwata Wakiko , Adachi Yoshihiro , Sesaki Hiromi , Iijima Miho
Published: January 2025

Epidermal growth factor receptor (EGFR) is a major oncogenic protein, and thus EGFR-targeting therapies are widely used in patients with various types of cancer, including lung cancer. However, resistance to EGFR inhibitors, such as erlotinib, presents a significant challenge in treating lung cancer. In this study, we established an EGFR-independent, erlotinib-resistant (ER) phenotype in lung cancer A549 cells by exposing them to erlotinib for an extended period. The resulting ER cells exhibited a dramatic increase in erlotinib resistance, a decreased EGFR protein level, and enhanced tumor growth, suggesting a robust mechanism bypassing EGFR inhibition. RNA sequencing identified the transcription factor GRHL2 as a critical player in this resistance. GRHL2 was upregulated in ER cells, and its knockdown and knockout significantly reduced erlotinib resistance. Further analysis revealed that GRHL2 upregulates the receptor tyrosine kinase HER3, and that HER3 knockdown similarly decreases the IC50 for erlotinib. Additionally, ER cells showed increased cell-cell adhesion, linked to upregulated E-cadherin. E-cadherin was found to be vital for erlotinib resistance, largely independent of GRHL2, highlighting multiple parallel pathways sustaining resistance. These findings provide a novel mechanism of drug resistance and suggest that combination therapies targeting both GRHL2-HER3 and E-cadherin-mediated pathways may be necessary to overcome erlotinib resistance in lung cancer.
In silico identification of the anticataract target of βB2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment
Authors: Onikanni Sunday Amos , Fadaka Adewale Oluwaseun , Dao Tran Nhat Phong , Munyembaraga Valens , Nyau Vincent , Sibuyi Nicole Remaliah Samantha , Ajayi Morenike Grace , Nhung Nguyen Thi Ai , Ejiofor Emmanuel , Ajiboye Basiru Olaitan , Le Minh Hoang , Chang Hen-Hong
Published: January 2025

Introduction

Severe protein clumping in the lens can block light and lead to vision issues in cataract patients. Recent studies have linked β-crystallins, which are key proteins in the lens, to the development of cataracts. Specifically, the S175G/H181Q mutation in the βB2-crystallin gene plays a major role in cataract formation.

Methods

To understand how this mutation can be activated, we utilized computational methods to predict activators from Phaseolus vulgaris. The Schrödinger platform was employed to screen bioactive compounds and simulate molecular interactions in order to analyze binding and structural changes.

Results

Our results indicated that these phytochemicals are stable near S175G/H181Q.

Discussion

These findings suggest novel approaches that could potentially be developed into effective anticataract medications through further refinement and additional testing, ultimately resulting in the creation of more potent agents for cataract treatment.
Akabane virus isolated from biting midges and its infection in local domestic animal, Yunnan, China: a field and laboratory investigation
Authors: Meng Jinxin , He Yuwen , Li Nan , Yang Zhenxing , Fu Si , Wang Dongmei , Xin Aiguo , Wang Jinglin , Liang Guodong
Published: January 2025

Introduction

We verified that Akabane virus (AKAV) is transmitted through biting midges and infects local domestic animals.

Methods

In 2013, viruses were isolate from biting midges in Yunnan, China, using BHK-21 and C6/36 cells. Two AKAV strains (No. 52 and 55) that induced cytopathogenic effects (CPE) in BHK-21, MDBK, and Vero cells were characterized.

Results

The complete genomic sequence of both viruses consisted three RNA segments (S, M, and L). The S segment (856 nucleotides) encoded a 233-amino-acid nucleocapsid protein and a 91-amino-acid nonstructural protein, while the M segment (4309 nucleotides) encoded a 1401-amino-acid polyprotein. The L segment (6869 nucleotides) encoded a 2511-amino-acid RNA-dependent RNA polymerase. Phylogenetic analysis revealed that specimen Nos. 52 and 55 clustered with AKAV genotype Ia viruses isolated from Asia. The AKAV strain (55) neutralizing antibody exhibited a total positive rate of 43.55% (202/466) against serum samples from cattle and goats collected in Yunnan Province. Specifically, the positive rates were 48.77% (139/285) for cattle and 34.81% (63/181) for goats. Neutralizing antibody titers in cattle (1:32–1:128) were higher than those in goats (1:4–1:16).

Discussion

This study represents the first isolation of AKAV from biting midges in China, along with the detection of high neutralizing antibody titers against AKAV in the serum samples of local cattle and goats. These findings suggested that biting midges are involved in AKAV transmission among domestic animals in Yunnan Province, China.
DMPNet: dual-path and multi-scale pansharpening network
Authors: Kaur Gurpreet , Malhotra Manisha , Singh Dilbag , Singhal Sunita
Published: January 2025

Introduction

Pansharpening is an important remote sensing task that aims to produce high-resolution multispectral (MS) images by combining low-resolution MS images with high-resolution panchromatic (PAN) images. Although deep learning-based pansharpening has shown impressive results, the majority of these models frequently struggle to balance spatial and spectral information, resulting in artifacts and a loss of detail in pansharpened images. Furthermore, these models may fail to properly integrate spatial and spectral information, leading to poor performance in complex scenarios. Additionally, these models face challenges such as gradient vanishing and overfitting.

Methods

This paper proposes a dual-path and multi-scale pansharpening network (DMPNet). It consists of three modules: the feature extraction module (FEM), the multi-scale adaptive attention fusion module (MSAAF), and the image reconstruction module (IRM). The FEM is designed with two paths, namely the primary and secondary paths. The primary path captures global spatial and spectral information using dilated convolutions, while the secondary path focuses on fine-grained details using shallow convolutions and attention-guided feature extraction. The MSAAF module adaptively combines spatial and spectral data across different scales, employing a self-calibrated attention (SCA) mechanism for dynamic weighting of local and global contexts and a spectral alignment network (SAN) to ensure spectral consistency. Finally, to achieve optimal spatial and spectral reconstruction, the IRM decomposes the fused features into low- and high-frequency components using discrete wavelet transform (DWT).

Results

The proposed DMPNet outperforms competitive models in terms of ERGAS, SCC (WR), SCC (NR), PSNR, Q, QNR, and JQM by approximately 1.24%, 1.18%, 1.37%, 1.42%, 1.26%, 1.31%, and 1.23%, respectively.

Discussion

Extensive experimental results and evaluations reveal that the DMPNet is more efficient and robust than competing pansharpening models.
Machine learning analysis of emerging risk factors for early-onset hypertension in the Tlalpan 2020 cohort
Authors: Martínez-García Mireya , Gutiérrez-Esparza Guadalupe O. , Márquez Manlio F. , Amezcua-Guerra Luis M. , Hernández-Lemus Enrique
Published: January 2025

Introduction

Hypertension is a significant public health concern. Several relevant risk factors have been identified. However, since it is a complex condition with broad variability and strong dependence on environmental and lifestyle factors, current risk factors only account for a fraction of the observed prevalence. This study aims to investigate the emerging early-onset hypertension risk factors using a data-driven approach by implementing machine learning models within a well-established cohort in Mexico City, comprising initially 2,500 healthy adults aged 18 to 50 years.

Methods

Hypertensive individuals were newly diagnosed during 6,000 person-years, and normotensive individuals were those who, during the same time, remained without exceeding 140 mm Hg in systolic blood pressure and/or diastolic blood pressure of 90 mm Hg. Data on sociodemographic, lifestyle, anthropometric, clinical, and biochemical variables were collected through standardized questionnaires as well as clinical and laboratory assessments. Extreme Gradient Boosting (XGBoost), Logistic Regression (LG) and Support Vector Machines (SVM) were employed to evaluate the relationship between these factors and hypertension risk.

Results

The Random Forest (RF) Importance Percent was calculated to assess the structural relevance of each variable in the model, while Shapley Additive Explanations (SHAP) analysis quantified both the average impact and direction of each feature on individual predictions. Additionally, odds ratios were calculated to express the size and direction of influence for each variable, and a sex-stratified analysis was conducted to identify any gender-specific risk factors.

Discussion

This nested study provides evidence that sleep disorders, a sedentary lifestyle, consumption of high-fat foods, and energy drinks are potentially modifiable risk factors for hypertension in a Mexico City cohort of young and relatively healthy adults. These findings underscore the importance of addressing these factors in hypertension prevention and management strategies.
TEVAR for acute type B aortic dissection in pregnant women (35 weeks gestation) with Takayasu's arteritis after cesarean section: a rare case report and literature review
Authors: Bi Taiyu , Duan Xiaotian , Yin Yipeng
Published: January 2025

Background

Takayasu's arteritis (TA) is an autoimmune disease that invades large arteries and mostly occurs in women of childbearing age. It leads to thickening and loss of elasticity of the arterial wall, and eventually vascular occlusion, aneurysm or dissection formation. Type B aortic dissection (TBAD) during pregnancy is a rare disease, which is mostly caused by the increase of blood volume in circulation during pregnancy, the effect of estrogen and progesterone on the aorta, or congenital diseases. TBAD in TA pregnant women is very rare, and the condition is often complicated. It is necessary to make a multidisciplinary treatment plan and determine the timing and method of operation to save the life of mother and fetus.

Case description

We report a pregnant woman at 35 weeks of gestation who presented to the emergency department with sudden and continuously unrelieved chest pain. She had TA for five years. Thoracoabdominal aortic computed tomography with angiography (CTA) showed acute TBAD. Her blood pressure was 209/73 mmHg and could not be lowered with Urapidil, therefore she was diagnosed with complex Stanford type B aortic dissection. She underwent cesarean section under general anesthesia, and the tracheal tube was not removed after surgery. Thoracic endovascular aortic repair (TEVAR) was administered under anesthesia 8 h after cesarean section. Intraoperative aortography showed that the stent blocked the tear of the intima of the aorta, and the false cavity was reduced. Her blood pressure was reduced to the normal range (140/90 mmHg or less), and the baby's vital signs were stable. They were discharged five days later. Use steroids to control TA throughout treatment. One year after the operation, the mother was healthy and the baby developed well.

Conclusion

Early identification and accurate diagnosis should be made for acute TBAD in late pregnancy. Under the premise of stable hemodynamics, the fetus is delivered by cesarean section first and then TEVAR is the preferred treatment. The diagnosis and treatment plan of AD during pregnancy should be developed and implemented by multiple disciplines according to the vital signs of mother and fetus. TA pregnant women should take steroids during pregnancy, closely detect inflammatory indicators, and avoid pathogenic microbial infection, inflammatory state and complications. At the same time, the necessary follow-up is also the key to ensure the treatment effect.
Envelope and intelligent prediction of horizontal bearing capacity for offshore wind monopiles in sandy seabed under HM combined loading
Authors: You Xin-Yu , Qian Shi-Yi , Li Bin , Wang Jun , Xu Ling-Yu
Published: January 2025

This study presents a practical finite element model for evaluating laterally loaded monopiles embedded in sandy seabed, verified through comparison with field test data from the PISA project. The classical Mohr-Coulomb model, used for soil plasticity in this study, provides reliable predictions and required parameters that are straightforward to determine, enhancing its utility in engineering practice. The numerical model, combines with an artificial neural network (ANN), provides a feasible approach to predict the bearing capacity of monopiles in offshore wind applications, even under different seabed conditions and combined horizontal (H) and moment (M) loads. Results reveal that the horizontal bearing capacity significantly varies depending on slope direction, with increased capacity in the slope upward direction and decreased capacity in the slope downward direction. An elliptical equation is developed to represent the horizontal bearing capacity envelope in the HM plane, accurately predicting ultimate horizontal force (Hu) and bending moment (Mu) across different length-to-diameter (L/D) ratios and seabed slopes. To further enhance predictive capability, an ANN surrogate model is developed, trained on 288 scenarios. Using L/D ratio, seabed slope, horizontal displacement and rotation angle at the monopile head as inputs, the ANN successfully predicts the horizontal bearing capacity with error margins within ±10%. This research offers a practical, validated finite element and ANN-based approach for modeling and predicting the lateral bearing capacities of monopiles in complex offshore environments, making it a valuable tool for the construction and measurement of offshore wind turbine foundations under HM loading conditions.
Smart learning and the law: examining the case of the Dubai Judicial Institute and its inevitable transition towards a modern pedagogical paradigm
Authors: Al-Mazmi Hind , Alzouebi Khadeegha , Charles Tendai
Published: January 2025

Traditional classroom teaching remains the primary mode of learning at the Dubai Judicial Institute (DJI), a public entity educating aspiring judiciary members and legal professionals. However, the DJI faces specific challenges in transitioning to a smart learning model, including the potential loss of valuable personal interaction, significant financial and technological requirements, and the need for staff training to adapt to new systems. Despite these hurdles, both management and learners at the DJI express readiness and enthusiasm for this paradigm shift, driven by the benefits of flexibility, time efficiency, and increased learner autonomy. This study identifies core challenges in transitioning to smart learning, highlights key andragogical practices, and evaluates the institute’s organizational readiness for change. The findings indicate that while the transition requires a phased approach and careful planning, it presents a significant opportunity to enhance judicial training. By embracing smart learning, the DJI can align with Dubai’s broader smart government initiatives, ultimately fostering a more efficient, accessible, and innovative justice system.