bluuebunny/crossref_metadata_2025 huggingface dataset:
The Predictive Value of Sepsis Scores for In-Hospital Mortality in Patients with Left-Sided Infective Endocarditis
Authors: Almeida Bianca Leal de , Strabelli Tania Mara Varejao , Bittencourt Marcio Sommer , Oliveira Vítor Falcão de , Gualandro Danielle Menosi , Mansur Alfredo Jose , Tarasouchi Flavio , Pocebon Lucas , Paixão Milena , Goldemberg Flora , Salomão Reinaldo , Siciliano Rinaldo Focaccia
Published: January 2024

Background: As infective endocarditis has particular characteristics compared to other infectious diseases, it is not clear if sepsis scores are reported with good accuracy in these patients. The aim of this study is to evaluate the accuracy of the qSOFA and SOFA scores to predict mortality in patients with infective endocarditis. Methods: Between January 2010 and June 2019, 867 patients with suspected left-sided endocarditis were evaluated; 517 were included with left-sided infective endocarditis defined as “possible” or “definite” endocarditis, according to the Modified Duke Criteria. ROC curves were constructed to assess the accuracy of qSOFA and SOFA sepsis scores for the prediction of in-hospital mortality. Results: The median age was 57 years, 65% were male, 435 (84%) had pre-existing heart valve disease, and the overall mortality was 28%. The most frequent etiologies were Streptococcus spp. (36%), Enterococcus spp. (10%), and Staphylococcus aureus (9%). The sepsis scores from the ROC curves used to predict in-hospital mortality were qSOFA 0.601 (CI95% 0.522–0.681) and SOFA score 0.679 (CI95% 0.602–0.756). A sub-group analysis in patients with and without pre-existing valve disease for SOFA ≥ 2 showed ROC curves of 0.627 (CI95% 0.563–0.690) and 0.775 (CI95% 0.594–0.956), respectively. Conclusions: qSOFA and SOFA scores were associated with increased in-hospital mortality in patients with infective endocarditis. However, as accuracy was relatively lower compared to other sites of bacterial infections, we believe that this score may have lower accuracy when predicting the prognosis of patients with IE, because, in this disease, the patient’s death may be more frequently linked to valvular and cardiac dysfunction, as well as embolic events, and less frequently directly associated with sepsis.
Radar Observations of Liquid Water in the South Polar Region of Mars: Indications from Astrobiology Perspectives
Authors: Zhou Junyi , Ding Chunyu , Xiong Siting , Su Yan , Li Jiawei , Chen Mengna , Dai Shun
Published: January 2024

In recent decades, extensive research has led to the understanding that Mars once hosted substantial liquid-water reserves. While the current Martian landscape boasts significant water-ice deposits at its North and South poles, the elusive presence of liquid-water bodies has remained undetected. A breakthrough occurred with the identification of radar-echo reflections at the base of the Martian South Pole, using MARSIS (Mars Advanced Radar for Subsurface and Ionospheric Sounding) in 2018. These radar echoes strongly suggest the presence of a highly concentrated liquid-water body. However, a counter-narrative has emerged, contending that the subterranean conditions beneath the ice cap, encompassing factors like temperature and pressure, may be inhospitable to liquid water. Consequently, alternative hypotheses posit that the observed bright echoes could be attributed to conductive minerals or water-absorbing clay-like materials. The ongoing discourse regarding the presence of liquid water beneath the southern polar ice cap is a hot topic in the realm of Martian exploration. The primary focus of this paper is to provide a comprehensive overview of Martian radar detection, the recent controversies regarding liquid water’s existence in the Martian South Pole, and the implications regarding the potential existence of Martian life forms in the water on Mars. The revelation of liquid water on Mars fundamentally suggests an environment conducive to the viability of Martian life, consequently furnishing invaluable insights for future exploratory endeavors in the pursuit of Martian biospheres. In addition, this paper anticipates the forthcoming research dedicated to Martian liquid water and potential life forms, while also underscoring the profound significance of identifying liquid water on Mars in propelling the field of astrobiology forward.
Comparisons of Different Machine Learning-Based Rainfall–Runoff Simulations under Changing Environments
Authors: Li Chenliang , Jiao Ying , Kan Guangyuan , Fu Xiaodi , Chai Fuxin , Yu Haijun , Liang Ke
Published: January 2024

Climate change and human activities have a great impact on the environment and have challenged the assumption of the stability of the hydrological time series and the consistency of the observed data. In order to investigate the applicability of machine learning (ML)-based rainfall–runoff (RR) simulation methods under a changing environment scenario, several ML-based RR simulation models implemented in novel continuous and non-real-time correction manners were constructed. The proposed models incorporated categorical boosting (CatBoost), a multi-hidden-layer BP neural network (MBP), and a long short-term memory neural network (LSTM) as the input–output simulators. This study focused on the Dongwan catchment of the Yiluo River Basin to carry out daily RR simulations for the purpose of verifying the model’s applicability. Model performances were evaluated based on statistical indicators such as the deterministic coefficient, peak flow error, and runoff depth error. The research findings indicated that (1) ML-based RR simulation by using a consistency-disrupted dataset exhibited significant bias. During the validation phase for the three models, the R2 index decreased to around 0.6, and the peak flow error increased to over 20%. (2) Identifying data consistency transition points through data analysis and conducting staged RR simulations before and after the transition point can improve simulation accuracy. The R2 values for all three models during both the baseline and change periods were above 0.85, with peak flow and runoff depth errors of less than 20%. Among them, the CatBoost model demonstrated superior phased simulation accuracy and smoother simulation processes and closely matched the measured runoff processes across high, medium, and low water levels, with daily runoff simulation results surpassing those of the BP neural network and LSTM models. (3) When simulating the entire dataset without staged treatment, it is impossible to achieve good simulation results by adopting uniform extraction of the training samples. Under this scenario, the MBP exhibited the strongest generalization capability, highest prediction accuracy, better algorithm stability, and superior simulation accuracy compared to the CatBoost and LSTM simulators. This study offers new ideas and methods for enhancing the runoff simulation capabilities of machine learning models in changing environments.
Risk factors for malignant oral mucosal lesion development (literature review). Part 2. Exogenous factors
Authors: Lunitsyna Yu. V. , Lazarev A. F. , Tokmakova S. I. , Bondarenko O. V.
Published: January 2024

Relevance. Cancer stands as a prominent cause of untimely mortality in young and middle-aged individuals (aged 20-64 years). The inquiry into the extent of influence exerted by external risk factors on the emergence of oral mucosal oncopathology remains pertinent. Equally crucial is understanding the intricate interplay among different groups of factors and their effects.

Research objective. To determine the extent of influence exerted by various endogenous and exogenous risk factors on the development of malignant oral mucosal lesions, based on contemporary literature data, and to assess their interrelationships.

Materials and methods. The research material was the analysis of literary data from bibliographic sources – Elsevier, PubMed, Elibrary, Google Academy, Medline, Cyberleninka. The study included literature sources in Russian and English. The second part of the review combines studies devoted to the study of the influence of exogenous controlled factors on the risk of developing malignant neoplasms of the oral mucosa.

Results. Through contemporary literature analysis, the potential and scale of influence attributed to controllable exogenous risk factors in the development of malignant oral mucosal lesions have been established. Notably, significant impact has been associated with smoking and alcohol consumption. Additionally, adverse socio-economic conditions, environmental factors, and dietary habits have been identified as contributors to an elevated cancer risk. Throughout this investigation, it became evident that literature sources frequently highlight the influence of individual factors without adequately considering potential synergies, antagonistic effects, or interactions with endogenous factors. Moreover, certain factors pivotal to the carcinogenesis of oral cavity tumors remain inadequately researched.

Conclusion. To facilitate efficient primary and secondary prevention measures, it is imperative to advance and refine a multidisciplinary research methodology. This approach should aim to comprehensively identify the collective impact of diverse groups of risk factors on the progression of malignant oral mucosal lesions.
Quelques réflexions sociolinguistiques sur les canons des conciles mérovingiens (VIe-VIIe siècles)
Authors: Plocharz Piotr
Published: January 2024

This article analyses canons of the Merovingian synods of the sixth and seventh century. Our sociolinguistic analysis confirms that early medieval Gaul was a full Latin-speaking country. Taking into account the history of medieval French literature, the analysis of these canons might suggest that the sources of medieval goliards date back much earlier than we thought, as early as the sixth century.
Novità lessicali nel Codice Diplomatico Barese (secoli X – XIII)
Authors: D'Argenio Elisa
Published: January 2024

Il Codice Diplomatico Barese è una delle raccolte documentarie più importanti dell’Italia meridionale e costituisce una preziosa fonte per arricchire e completare le informazioni disponibili nei dizionari del latino medievale. Il presente contributo segnala e analizza alcune novità lessicali dei primi due volumi del Codice Diplomatico Barese non registrate nei dizionari della latinità medievale. Si tratta di nuove grafie di termini già noti (alubnus, aurileria, berzarum, condaky, cossobrinus, cossoprinus, piziolum, pumettus), di neologismi semasiologici (ralla, trofa) e di neologismi semantici (addoator, azza, caditizzus, casanatizza, cocibelina, critazzina, crudia, cutizza, gayfus, naranginus, pellictionum, prekium, quartararus, scarparius, spurgator, termitosus).
Bartolomeo Anglico, «the English Pliny» ?
Authors: Lonati Elisa
Published: January 2024

Il presente contributo si propone di condurre un’analisi esaustiva delle riprese che il De proprietatibus rerum del francescano Bartolomeo Anglico († dopo il 1245) trasse dalla Naturalis historia di Plinio il Vecchio, soprattutto in ambito zoologico e botanico. Rivelando un ampio numero di passi erroneamente attribuiti a Plinio, l’inchiesta spinge ad interrogarsi sulle ragioni dello scambio con auctoritates

concorrenti, nonché a risalire alle vere fonti di determinate riprese, solo alla lontana dipendenti dalla Naturalis historia. Il confronto sistematico con il testo di quest’ultima offre inoltre l’occasione di identificare un piccolo gruppo di manoscritti pliniani, cui il modello di Bartolomeo presumibilmente apparteneva, e solleva numerose problematiche metodologiche soprattutto in merito a sezioni del De proprietatibus rerum ancora prive di un’edizione critica.
Le manuscrit Paris, BnF, lat. 2306 des Sententiae de Taion de Saragosse : étude d’un exemplaire de la bibliothèque de Jacques-Auguste de Thou
Authors: Aguilar Miquel Julia
Published: January 2024

Le manuscrit Paris, BnF, lat. 12265 des Sententiae de Taion de Saragosse (VIIe siècle) a été copié dans le scriptorium de Saint-Germain-des-Prés dans la seconde moitié du XVIIe siècle ; l’editio princeps de l’Epistula ad Quiricum Barcinonensem antistitem (prologue des Sententiae), de son côté, a été préparé par Luc d’Achery et Jean Mabillon dans la même institution en 1669. Ces deux témoins semblent avoir utilisé comme modèle le même exemplaire : un manuscrit carolingien appartenant à la célèbre bibliothèque de Jacques-Auguste de Thou (1553-1617), qui n’était pas identifié jusqu’à présent. L’étude du texte permet d’affirmer que ce manuscrit est en fait le manuscrit Paris, BnF, lat. 2306. Ce travail fournit des preuves textuelles, codicologiques et historiques permettant de démontrer cette hypothèse et de déterminer quelles sont les relations exactes de ces deux manuscrits (lat. 2306 et lat. 12265) et l’édition de Mabillon.
Una nuova ipotesi su bannita (sillaba) nel latino medievale
Authors: Spangenberg Elena Yanes
Published: January 2024

The first part of the paper focuses on the word bannita, which occurs in some early medieval Latin grammatical works with the meaning of ‘ syllable’. In 1976 Bernhard Bischoff explained the uncertain origin of this term conjecturing that it resulted from the wrong separation of the words in a Greek phrase transliterated into Latin and corrupt in book 1 of Isidorus’ Etymologiae. This explanation has been accepted for a long time, but now the first complete collation of the medieval manuscripts of Sergius’ Commentarium de litteris reveals that bannita occurs as a self-standing word already in the majority of Sergius’ early medieval witnesses. It is therefore possible to identify in Sergius’ manuscript tradition rather than in that of Isidorus the source for such medieval neologism. The second part of the paper investigates the peculiar use of bannita as “ letter” in the Tractatus super Donatum by Erchanbert of Freising, placing it in the context of the Irish scholarly circles and scriptoria in Carolingian Europe.
O transporte escolar rural na cidade de Santana do Livramento –RS
Authors: Figueroa Adílio , Rigon Algacir José , Bucco Nádia Fátima dos Santos , Moraes Maria Silvana Aranda , Rodrigues Renato Machado , Brum Alexandre Antunes , Brum Aline Neutzling
Published: January 2024

O presente trabalho busca discutir as problemáticas da terceirização do transporte escolar por parte do Estado do Rio Grande do Sul da linha que liga o Centro de Santana do Livramento - RS a uma Escola Estadual de Ensino Médio, que está localizada em uma área que abrange a Educação do Campo. Para isso, foram entrevistados os usuários (professores, alunos e responsáveis pelos alunos) do serviço com o objetivo de evidenciar o grau de satisfação dos mesmos. Para a coleta dos dados, foi realizado questionário semiestruturado, com perguntas abertas e fechadas. Nesse sentido, o presente estudo baseia-se nas ideias de Almeida (1992), Oliveira e Barvin (2010) e Soares e Calda (2018), que discutem a validez da terceirização do transporte escolar. Com isso, a partir da análise das respostas obtidas, pode-se entender os benefícios e os prejuízos da terceirização do transporte escolar da linha mencionada anteriormente.
Integrated marketing communication through digital channels in context of Generation Z in Slovakia
Authors: Drábik Peter , Škerlíková Dominika , Ožvoldová Katarína , Korčoková Marína , Kuchta Martin
Published: January 2024

Generation Z represents a significant part of today’s society and therefore understanding their buying behavior is a key point of companies’ marketing strategies. The main objective of this paper is to investigate selected aspects of Generation Z’s behavior in the online environment as well as to explore the differences in this behavior due to gender. Based on descriptive and inductive statistics, it was possible to identify important factors of Generation Z’s purchasing behavior as well as their perception of the benefits of online shopping itself. An important outcome is also the design of a Generation Z customer journey map that describes the customer journey of their online purchase. The study deepens previous research on the application of the models to a selected segment of customers and at the same time, its limitations create scope for exploring intergenerational differences in consumer behavior in both online and offline environment.
Using A. I. for the generation of visual references in digital audio games from the perspective of sound design
Authors: Farkaš Tomáš , Schwarz Martin
Published: January 2024

The aim of this article is to examine the application of artificial intelligence in producing visual references during the development of a digital game. These references are a standard inclusion in Game Design Documents or Art Design Documents and are typically displayed as mood boards. In this article, we will discuss sound design and how artificial intelligence, mainly Bing utilizing Dall-E and Midjourney, can produce images that cater to the requirements of a particular game. One of the primary issues we will explore is the efficiency of using artificial intelligence in this creative process in terms of speed, accuracy, efficacy, creativity and how the resulting content compares with human-generated content. One objective is to examine how artificial intelligence can produce visual references that exemplify more detailed sound groups, such as ambiences or interactive sounds linked with specific in-game activities. These visual references will undergo testing within a digital game presently under development, thus achieving validation through real-world application. The game’s genre is an audio game with no standard graphics or interface, tailored to the needs of players with visual impairments. For that reason, generating visual references remains the sole approach to comprehending the actual game environment.
AI in radio: The game changer you did not hear coming
Authors: Furtáková Lucia , Janáčková Ľubica
Published: January 2024

AI technologies are becoming more accessible to the public, leading to an increase in their use. This trend can also be observed in radio, where artificial intelligence is gradually finding its application in various forms and radio professionals are increasingly trying it out in practice. This study provides an overview of the use of AI in radio in Slovakia and abroad in different contexts. So far, AI has only been used to a limited extent in the generation of texts in Slovak, which leaves room for further development in this direction, but also for the need for constant control of documents and materials created for broadcasting. Radio stations use artificial intelligence to automate processes in the preparation of broadcasts, from the selection of songs to the generation of news. Despite these capabilities, there is still a need for human control and creativity in content creation. Radio is looking to use AI to improve the listener experience, although there are challenges such as language barriers and maintaining human authenticity in moderation. The study also discusses radio professionals’ perspectives on the use of AI and its future in radio.
Brand dilemmas in the context of changes in consumer behaviour related to market crises
Authors: Galera Matúšová Jana
Published: January 2024

The current macroeconomic environment poses major challenges for brands and their communications. Consumer buying behaviour is changing, pressures on marketing budgets are mounting, the question of the meaningfulness of brand campaigns at the expense of performance is much more open in uncertain times. At the same time, brands are trying to work more with price to respond to the cooling of consumer behaviour. Pandemics, the war in Ukraine, high inflation, the conflict in Israel – all bring new challenges for brands and their marketing/communications budgets. At the same time, Generation Z is becoming economically active, which research says is very different from previous generations. Both in terms of consumer behavior and media consumption, but it is also a challenge for employers, as their work expectations are also different than they were for previous generations. Thus, the paper raises several communication dilemmas for brands in a dynamic environment based on an analysis of secondary research, relevant scholarly and professional sources, insights from Marketing Rulezz conferences and brand examples. The article is based on the topic of the VEGA project.
Opinion balance of news in the time of mistrust in media and democratic institutions
Authors: Greguš Ľuboš , Škvareninová Simona
Published: January 2024

The paper deals with the opinion balance of news in television broadcasting. In the context of ever-increasing mistrust in traditional media and democratic systems and the polarization of society, we try to point out the current state of media production in this specific area, considering its possible consequences for the perception of the media by the recipients. They are increasingly turning to alternative or even disinformation media to obtain information other than mainstream. In our research part, we are looking for a current state of the balance of opinions, which should be part of well-functioning and objective reporting and should inspire people’s trust in television broadcasting. The article offers the results of research carried out on a sample of 374 television contents broadcast by the public broadcaster RTVS and the authorized broadcaster TV Markíza in the period from February 12th, 2023, to March 25th, 2023. From the data, it is possible to conclude that there are deficiencies in television news from the point of view of maintaining impartiality in broadcasting
The effect of visual smog on the buying behaviour of the millenial generation
Authors: Havíř David , Kaňovská Lucie
Published: January 2024

Visual smog is the pollution of public space by aggressive advertising that is not adapted to the character of the environment. In a broader context, it is anything that negatively affects a person’s visual experience in a public space. At the same time, the visual smog created by a particular company may contribute to a reduced intention to buy its products, as these companies may be perceived as too aggressive and not respecting the character of urban areas. The aim of the paper was to determine the effect of visual smog on the buying behavior of the millennial generation. 210 respondents took part in the survey. The results show that almost three quarters of respondents report that they do not shop according to outdoor advertising. Almost a quarter of respondents report that they do not purchase from companies that use outdoor advertising. Just under 30% of respondents would stop buying from a company that contributes to outdoor advertising overload, showing so far relatively little impact of visual smog on brand perception in terms of reduced purchase tendencies. Visual smog is a trending topic in relation to outdoor spaces in cities, but in terms of visual experience, it is not just about the physical environment. We can also see advertising overload in the online space. The rise of augmented reality, virtual worlds and the metaverse is creating new spaces that can be used for advertising purposes. In addition, however, ad space providers will be able to obtain detailed data on the perception and impact of ads at the individual level, giving them an even greater advantage over those who believe they are not influenced by advertising.
Time to say goodbye: A neuromarketing perspective
Authors: Jukić Dinko
Published: January 2024

Study research neuromarketing from the aspect of consumer emotions. It starts from the analysis of the phenomenon of neuromarketing and brand image. Unconscious reactions and the role of emotions in purchasing decisions are considered. The aim of the study is to research and show the influence of neuromarketing in the context of consumer choices from the aspect of emotions and AI. The study compares Keller’s theory of brand image and Damasio’s theory of emotions. The use of AI accelerates and expands the development of neuromarketing because it directs the consumer to his desires, offering him what he searches, watches, reads, and does. In the study, the ethical questions of neuromarketing are opened, because knowledge about the consumer’s desires is revealed on an unconscious level, which, using neuroscientific methods, is displayed in the brain. The role of emotions is extremely important when choosing a brand because consumers do not always react rationally. This means that emotions come to the surface as a result of triggers that we often do not consciously recognize. And precisely such feelings represent the private thing that neuromarketing detects and AI connects. The reference to the song Time to Say Goodbye is a metaphor for marketing that is put to the test of neuroscience and ethics by exposing the hidden desires of consumers. This study provides a theoretical framework about neuromarketing, AI, emotions, and ethics.
Challenges and opportunities of AI in individual marketing communication tools
Authors: Galera Matúšová Jana , Kusá Alena , Pátík Ladislav
Published: January 2024

Artificial Intelligence is nowadays being discussed in several directions, but as far as the fields are concerned, the most discussed are its use in marketing, banking, journalism or education sector. Marketing is mainly included in this direction in terms of textual and visual forms of AI, such as ChatGPT, Jasper, Copy.ai, Writesonic, Midjourney, DALL-e or Bart. It is the development or expansion of these tools that dates in our country from the end of 2022 and is mainly associated with the debate whether and to what extent artificial intelligence will replace some positions. And this also in marketing. Today, in this area, we are talking more about the streamlining of some activities, which we will address in our article. However, we understand that this area requires further research in order to verify the implementation of AI tools in marketing from a scientific point of view. However, it is important to understand that AI tools have a dynamic evolution and thus what applies to them today changes over time. At the same time, new tools are constantly being added and are also entering new areas (for example, a tool for composing music).
The role of artificial intelligence in neuromarketing research: Insights and applications
Authors: Kusá Alena , Beličková Patrícia
Published: January 2024

Conventional marketing research tools, such as surveys and focus groups, assess customer reactions to different product aspects. However, these methods often fall short of capturing the intricacies of the customer’s mindset, as responses may not always be entirely truthful. This is where the neuromarketing proves valuable. The paper explores how AI-driven algorithms and technologies have revolutionized the understanding of consumer behaviour and decision-making processes, offering insights into the subconscious processes governing decisionmaking. AI’s integration enables real-time feedback through technologies such as facial recognition, eyetracking, and sentiment analysis. This immediacy empowers marketers to optimize strategies dynamically, enhancing campaign efficacy. The paper addresses the ethical considerations arising from this integration, emphasizing the importance of responsible AI use in neuromarketing research. The synthesis of AI and neuromarketing not only revolutionizes data interpretation but also navigates the ethical dimensions of consumer privacy and consent. This research provides a comprehensive overview of the symbiotic relationship between AI and neuromarketing, offering valuable insights into the future of consumer engagement and marketing strategies. By harnessing AI’s capabilities, this research showcases the novel avenues for enhancing consumer experiences and optimizing marketing strategies. The paper offers a comprehensive overview of the applications of AI in neuromarketing and underscores its potential to unlock deeper insights into consumer behavior and preferences.
The importance of relationship marketing in the process of electronic commerce
Authors: Štofejová Lenka , Fedorko Richard , Kráľ Štefan
Published: January 2024

Presently, the customer takes center stage in the realm of sales, playing a pivotal role in the establishment of enduring relationships and loyalty. This shift implies a transformation in the dynamics between sellers and customers, with sellers increasingly incorporating elements of relationship marketing. This paper offers an overview of issues related to relational marketing within the context of electronic commerce, highlighting its significance in fostering relationships between online sellers and customers in the digital environment. The advent of the digital age has also brought about changes in how sellers engage with customers. There is a growing emphasis on relationship marketing, a strategy used to cultivate and sustain long-term connections with customers. There is also a growing prominence of artificial intelligence systems. Artificial intelligence is widely used in customer relationship management. The surge in e-commerce has amplified interest in relationship marketing, prompting a deeper understanding of fundamental aspects in forming online relationships with consumers. It is imperative for sellers to formulate and execute relational marketing strategies and to implement artificial intelligence systems within sales and communication processes, ultimately providing them with a competitive edge and fostering consumer loyalty. E-commerce plays a pivotal role in this evolving landscape.
The impact of cinacalcet on the serum phosphorus, calcium and PTH levels in dialysis patients; a systematic review and meta-analysis
Authors: Yarahmadi Mehdi , Moonesan Mohammad Reza
Published: January 2024

Introduction: Cinacalcet is a medication prescribed to manage hypercalcemia and hyperparathyroidism in patients with chronic kidney diseases. The present study aims to evaluate the impact of cinacalcet on serum levels of calcium, phosphorus, and parathyroid hormone (PTH) in patients undergoing dialysis using a systematic review and meta-analysis approach. Materials and Methods: This study was conducted based on the PRISMA guidelines. A literature search without time restriction was performed on international databases, including Cochrane, Web of Science, Scopus, and PubMed. Data were analyzed using STATA 14 software at a significance level of P<0.05 for all tests. Results: The present meta-analysis involved twelve studies with a sample size of 1131 patients. A reduction was noted in the serum levels of calcium [SMD: -1.32 (95% CI: -2.64, -0.01)], PTH [SMD: -3.95 (95% CI: -6.53, -1.37)], phosphorus [SMD: -1.61 (95% CI: -3.01, -0.20)] and Ca×P [SMD: -5.33 (95% CI: -10.16, -0.49)] after cinacalcet use in dialysis patients. However, the variations in serum levels of alkaline phosphatase were non-significant [SMD: -0.09 (95% CI: -0.94, 0.77)]. In addition, the effectiveness of cinacalcet use on calcium serum level reduction in dialysis patients was verified at a daily dose of 30-60 mg [SMD: -0.83 (95% CI: -1.25, -0.42)] and consumption duration of 24 months [SMD: -1.26 (95% CI: -1.66, -0.87)]. Conclusion: The administration of cinacalcet significantly decreased the serum calcium, phosphorous, PTH, and Ca×P product in dialysis patients. The lowest and highest effects of cinacalcet were found for calcium and Ca×P products, respectively. The prescription of this drug appears more effective in improving hypercalcemia in dialysis patients. Registration: This investigation has been conducted in accordance with the PRISMA checklist, and its protocol was registered on the PROSPERO platform (ID: CRD42023428774).
The Determination of Development Priorities Road Infrastructure at “Dinas Pekerjaaan Umum dan Penataan Ruang Kabupaten Balangan” Using AHP and Bayes Methods
Authors: Haderiansyah Haderiansyah , Mahdiana Deni , Wiranata Ade Davy , Sutrisno Mirza
Published: January 2024

The construction industry is a significant part of the gross domestic product of any country, and its success can lead to the long-term economic and social development of lives in general. Many studies have found a positive link between public infrastructure and the economy. Infrastructure investment directly affects economic growth. Well-designed infrastructure will have long-term financial benefits. The Ministry of Public Works and Housing (Pekerjaan Umum dan Perumahan Rakyat / PUPR) has played an essential role in strengthening the monitoring and evaluation of the implementation of infrastructure development by local authorities, including making the right policies in determining infrastructure development priorities. The Analytical Hierarchy Process (AHP) and Bayes method were used in this study. First, we used AHP to derive independent weights for criteria. Then, we determined the closeness between priorities to produce a sequence of infrastructure development priorities. Based on the results, using Analytical Hierarchy Process (AHP) and Bayes Method showed that Lampihong-Panaitan, Halong-Tabuan, and Bihara-Tariwin roads are Priorities for development. Then the Wangkili-Pudak road, and finally, the Awayan-Bihara. Decision support systems using the AHP and Bayes methods can determine priorities for road infrastructure development at the Office of Public Works and Public Housing in Balangan Regency.
The Potential of Human Mesenchymal Stem Cells in the Treatment of Immune Thrombocytopenia
Authors: Фролова Р.Л. , Исайкина Я.И. , Углова Т.А. , Жерносеченко А.А. , Лях Е.Г. , Новикова М.А. , Савич Ю.В.
Published: January 2024

Представлен обзор опубликованных фундаментальных исследований роли иммунных механизмов в патогенезе ИТП и иммуномодулирующего действия мезенхимальных стволовых клеток (МСК), а также результаты первых клинических испытаний применения МСК для лечения взрослых пациентов с ИТП. Последние данные подтверждают способность МСК подавлять аутореактивные иммунные процессы, лежащие в основе ИТП, в экспериментах in vitro и in vivo. Клеточная терапия МСК уже показала свою безопасность и эффективность для лечения рефрактерной ИТП в исследованиях с небольшим числом взрослых пациентов, но существует необходимость в проведении проспективных рандомизированных клинических испытаний для подтверждения терапевтического эффекта этого нового метода лечения ИТП как у взрослых, так и у детей.

The latest data confirm the ability of allogeneic mesenchymal stem cells (MSCs) to downregulate autoreactive immune processes underlying the ITP, both in vitro and in vivo experiments. The safety and efficacy of the MSCs transplantation have been demonstrated in studies that included a small number of adult patients with refractory immune thrombocytopenia. In the future, large randomized clinical trials are needed to confirm the efficacy of MSCs application for ITP therapy in adult and children.
Features of c.1934dupG Mutation in ASXL1 Gene in Myelodysplastic Syndrome
Authors: Липилкин П.В. , Кулаева Е.Д. , Арамова О.Ю. , Корниенко И.В. , Рябикина Е.В. , Дегтерева Е.В. , Шатохин Ю.В.
Published: January 2024

Мутация c.1934dupG в гене ASXL1 при миелодиспластическом синдроме связана с плохим прогнозом и низкой общей 5-летней выживаемостью, а также с высоким риском трансформации в острый миелоидный лейкоз. Большинство исследований этой мутации при миелодиспластическом синдроме проводилось в основном с помощью секвенирования, которое имеет ограниченную ценность в клинической практике из-за сложности рутинного использования. Хотя c.1934dupG является наиболее распространенной мутацией ASXL1 в гематологических опухолях, она мало изучена при миелодиспластическом синдроме с точки зрения ее влияния на тяжесть заболевания. Поэтому мы провели пилотное исследование, в котором рассмотрели субъективные и объективные критерии течения миелодиспластического синдрома в зависимости от мутационного статуса c.1934dupG. Мы использовали модифицированную аллель-специфическую ПЦР и секвенирование по Сэнгеру для исследования мутации в различных вариантах миелодиспластического синдрома. Наше исследование показало, что мутация c.1934dupG встречается чаще у мужчин с миелодиспластическим синдромом, но не влияет на общую выживаемость и другие клинические, биохимические или иммунофенотипические параметры. Мы ставим под сомнение влияние c.1934dupG, как наиболее частой мутации в гене ASXL1, на прогноз миелодиспластического синдрома.

The c.1934dupG mutation in the ASXL1 gene in myelodysplastic syndrome (MDS) is associated with a poor prognosis for overall 5-year survival and a high risk of transformation into acute myeloid leukemia (AML). Most studies of this mutation in MDS have been performed primarily with sequencing, which has a limited value in clinical practice because of the difficulty of routine use. Although c.1934dupG is the most common mutation in ASXL1 in hematologic tumors, it has been poorly studied in MDS in terms of its effect on the severity of the disease. Therefore, we conducted a pilot study that considers subjective and objective criteria for the course of MDS depending on the mutational status of c.1934dupG. We used modified allele-specific PCR and Sanger sequencing to investigate the mutation in different MDS variants. Our study found that the c.1934dupG mutation was associated with male sex, but not with the overall survival, other clinical, biochemical or immunophenotypic parameters. We cast doubt on the influence of C.1934dupG as the most frequent mutation in the ASXL1 gene on the MDS prognosis.
Diffusion-Weighted Magnetic Resonance Imaging for Non-Hodgkin’s Lymphomas. Literature Review and Own Clinical Experience
Authors: Алексеев С.А. , Троян В.Н. , Рукавицын О.А. , Троян Э.Р.
Published: January 2024

Данный литературный обзор посвящен анализу возможностей применения одного из современных доступных методов лучевой диагностики у пациентов с неходжкинскими лимфомами для оценки лечения и выявления рецидива заболевания. Это метод диффузионно-взвешенной магнитно-резонансной томографии всего тела (ДВ МРТ), который набирает популярность и является возможной альтернативой использующимся традиционным методам, таким как КТ и ПЭТ/КТ с 18F-ФДГ. В обзоре обсуждаются не только преимущества метода, но также недостатки и подводные камни, с которыми приходится сталкиваться врачу-диагносту.

This literature review is devoted to analyzing the possibilities of using one of the modern available methods of radiodiagnosis in patients with non-Hodgkin lymphoma to evaluate treatment and detect relapse of the disease. This is a whole-body diffusion-weighted magnetic resonance imaging (DWMRI) technique that is gaining popularity and is a possible alternative to current conventional techniques such as CT and 18F-FDG PET/CT. The review discusses not only the advantages of the method, but also the disadvantages and pitfalls that the diagnostician has to face.
Management of a Patient with Primary Mediastinal Large B-Cell Lymphoma Associated with Coronavirus Infection Caused by SARS-CoV-2: Own Clinical Case
Authors: Поляков Ю.Ю. , Барях Е.А. , Мисюрина Е.Н. , Желнова Е.И. , Мингалимов М.А. , Толстых Т.Н. , Чуднова Т.С. , Кочнева О.Л. , Иванова Д.Д. , Зотина Е.Н. , Гаглоева Д.Э. , Паршин В.В. , Лысенко М.А.
Published: January 2024

Коронавирусная инфекция (COVID-19) – это острое респираторное заболевание, вызванное вирусом SARS-CoV-2, впервые было отмечено в городе Ухань (Китай) и быстро распространилось по всему миру. В условиях пандемии COVID-19 проведение специфического противоопухолевого лечения у пациентов с агрессивными В-клеточными лимфомами стало одной из сложных задач. Проведение специфической противоопухолевой терапии пациентов с гемобластозами, в том числе с агрессивными лимфопролиферативными заболеваниями, требует безотлагательного начала. Отсрочка специфической терапии может привести к прогрессированию лимфомы. Выбирая протокол химиотерапевтического режима, необходимо учитывать риск реактивации COVID-19 на фоне миелотоксической аплазии костномозгового кроветворения, а также дополнительного присоединения бактериальной и грибковой инфекции. Подтвержденная коронавирусная инфекция не должна быть противопоказанием к химиотерапии. В данной публикации представлены собственное клиническое наблюдение течения COVID-19 у пациента с первичной медиастинальной В-клеточной лимфомой на этапе химиотерапевтического лечения, а также выбор режима противоопухолевой терапии.

Coronavirus disease (COVID-19) is an acute respiratory disease caused by the SARS-CoV-2 virus, was discovered first in Wuhan (China) and quickly spread throughout the world. Specific antitumor treatment in patients with aggressive B-cell lymphomas has become one of the most challenging issues in the context of the COVID-19 pandemic. An immediate start of specific antitumor therapy for patients with hematological malignancies including aggressive lymphoproliferative diseases (LPD) is required. The delay of specific therapy may lead to progression of lymphoma. It is necessary to consider the risk of reactivation of COVID-19 due to myelotoxic aplasia of bone marrow hematopoiesis, as well as further development of bacterial and fungal infections when choosing a chemotherapy regimen protocol. Confirmed COVID-19 infection should not be a contraindication for chemotherapy. This publication presents our own clinical experience of COVID-19 infection case in a patient with primary mediastinal B-cell lymphoma at chemotherapy treatment stage, as well as the choice of tactics for the antitumor therapy regimen.
Pengaruh Keragaman Gender Dewan Direksi Terhadap Kinerja Perusahaan yang Terdaftar Di BEI
Authors: Natalia Felisha , Chandra Budi , Ivone
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh keragaman gender dewan terhadap kinerja perusahaan finansial yakni perbankan & asuransi yang terdaftar di Indonesia pada periode antara 2017-2021. Variabel Dependen adalah ROA (Return on Assets), sedangkan variabel independen Female Director Blau Index, Umur, Foreign Women Directors, dan Masa Jabatan dengan variabel moderasi yaitu Accounting Expertise. Sampel penelitian Perusahaan yang terdaftar di Bursa Efek Indonesia, dipilih dengan metode purposive sampling, diperoleh 60 perusahaan yang memenuhi kriteria selama 5 tahun. Analisis untuk menguji pengaruh masing-masing variabel independen terhadap dependen adalah dengan menggunakan Regresi Data Panel. Fixed Effect Model  merupakan model regresi terbaik dalam penelitian ini. Hasil penelitian mencerminkan bahwa Female Director Blau Index memiliki pengaruh signifikan positif terhadap ROA (Return on Assets). Sementara itu, Umur, Foreign Women Directors, dan Masa Jabatan tidak memengaruhi ROA (Return on Assets).
A Crisis Caused by Confusion in the Concept of Essential
Healthcare
Authors: KIM Mijin
Published: January 2024

Korean society is currently experiencing a crisis in essential healthcare. While
the government has expanded essential healthcare, it has been unable to provide
essential medical services through private medical institutions due to a
shortage of public medical institutions. Legislators have proposed a bill to
resolve the shortage of medical personnel, but the obscurity of some of the key
concepts contained in the bill has so far prevented it from becoming law. One
fundamental problem in solving the current crisis is that there seems to be no
agreement on what essential healthcare is. Widely understood concepts help form
the basis for communication and empathy, reduce conflicts, and lead to efficient
discussions on policymaking. This commentary argues that to overcome the current
crisis all relevant parties must come to an agreement on what essential
healthcare is.
Medical Professionalism Version 2.0
Authors: LEE Kyungdo
Published: January 2024

In the article “The crisis in the essential healthcare system and medical
professionalism,” the author suggests that discussions about how to solve the
crisis in the South-Korean essential healthcare system should be grounded in
medical professionalism, which is itself based on the individual doctor-patient
relationship. The author claims that restoring medical professionalism will
mitigate the negative consequences of the current crisis by preventing doctors
from prescribing unnecessary treatments and therefore restraining medical
consumerism and the rapid expansion of the private health insurance system. This
commentary raises questions about how medical professionalism, of which the
primary focus lies in the individual doctor-patient relationship, could be
applied in the macro-level. It is argued that in order to address macro-level
healthcare issues, the conventional concept of medical professionalism needs to
be revised and strengthened.
A Proposal for a Virtue-based Medical Ethics Education Model for
Health Professionalism
Authors: MOK Kwangsu
Published: January 2024

This commentary argues that although the author of the target article correctly
characterizes the contemporary understanding of medical professionalism as
guideline-driven, he errs in classifying negative guidelines as ‘normative
ethics’ and proposing ‘positive ethics’ as an alternative. The problem with what
the author calls ‘guideline-driven’ medical professionalism is that it
understands ethics only in terms of its ‘institutional tier,’ which is one of
three recognized tiers in ethics terminology. To respond to this problem, it is
necessary to complement the ‘individual tier” of ethics, which internalizes the
normativity of the first-person perspective and motivates ethical practice, with
other elements. To this end, this commentary proposes to construct a
virtue-based medical ethics education model, one that is analogous to the
scientific virtue model. The construction of this virtue-based medical ethics
education model involves three steps: (a) developing a list of medical virtues,
(b) exploring how medical virtues can be taught, and (c) holding medical virtue
education workshops. Just as the scientific virtue model has proven its
practical effectiveness through three steps, it is expected that the
virtue-based medical ethics education model proposed in this article will play
an important role in overcoming the crisis in Korean healthcare.
Hubungan Dukungan Ayah ASI Terhadap Pemberian ASI Eksklusif
Authors: Fatimah  , Roza Adila Dian , Niriyah Sekani
Published: January 2024

Father's support for breastfeeding is one of the factors that influence a mother to breastfeed exclusively. This study aims to find out the relationship between father's support and exclusive breastfeeding. This type of research is quantitative using a descriptive correlational design and a cross-sectional approach. The sample for this study consists of 50 respondents who are mothers with babies aged 0-6 months who are registered at the Langsat Health Center. Sampling uses random sampling techniques. Data collection using questionnaires. Analysis in this study uses bivariate with the Chi-Square test. The result of the study on the characteristics of respondents aged 26-35 years is a total of 29 respondents (58%), the average number of respondents who are multiparous is 33 respondents (66%), the average ethnicity of the mother is Malay is 26 people. respondents (52%), the average mother's education, i.e. secondary education, was obtained by 34 respondents (68%), the average mother's occupation, i.e. not working, was obtained by 35 respondents (70%), while the father's education, i.e. secondary education, was obtained by 35 respondents (70%) and the average occupation of the father is self-employment. There are 21 respondents (42%). The results of the study showed that exclusive breastfeeding was obtained by 37 respondents (74%), and good breastfeeding father support was obtained by 25 respondents (50%). Bivariate analysis using the Chi-Square test showed a P value of 0.107 (P>0.05), meaning that there is no relationship between breastfeeding father support and exclusive breastfeeding. The community health center is expected to educate the community about the importance of the family's role in the influence of exclusive breastfeeding.
Keyword : Exclusive Breastfeeding, Breastfeeding Father