bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model
Authors: Othman Zaidatul Akmal , Zakaria Zaida , Suleiman Joseph Bagi , Ghazali Wan Syaheedah Wan , Mohamed Mahaneem
Published: February 2021

Obesity is typically linked to oxidative stress and inflammation, which lead to vascular damage and initiate the progression of atherosclerosis. The aim of this study was to determine the anti-atherosclerotic effect of orlistat on obesity-induced vascular oxidative stress in obese male rats. Twenty-four male Sprague–Dawley rats were categorized into two groups: normal (Normal group, n = 6) and high-fat diet (HFD group, n = 12). After six weeks, obese rats in the HFD group were administered either with distilled water (OB group) or orlistat 10 mg/kg/day (OB/OR group) for another six weeks. The OB group had a significant increase in lipid profiles (total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL)) and decrease in high-density lipoprotein (HDL) level compared to the Normal group. The aortic antioxidants enzymes activities (superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and catalase (CAT)) as well as total glutathione (GSH) and total antioxidant capacity (TAC) of the OB group were significantly decreased compared to the Normal group. Furthermore, pro-inflammatory atherosclerotic markers (tumour necrosis factor-alpha (TNF-α), vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1)) expressions were increased significantly, and anti-inflammatory marker (interleukin-10 (IL-10)) was decreased significantly in the OB group compared to the Normal group. Treatment with orlistat significantly improved lipid profile, increased antioxidant enzymes and expression of anti-inflammatory markers, and decreased the expression of the pro-inflammatory marker compared to the OB group. These findings may suggest the therapeutic effect of orlistat in attenuating the progression of the atherosclerotic stage in obesity.
Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study
Authors: Pincemail Joël , Cavalier Etienne , Charlier Corinne , Cheramy–Bien Jean-Paul , Brevers Eric , Courtois Audrey , Fadeur Marjorie , Meziane Smail , Goff Caroline Le , Misset Benoît , Albert Adelin , Defraigne Jean-Olivier , Rousseau Anne-Françoise
Published: February 2021

Background: A key role of oxidative stress has been highlighted in the pathogenesis of COVID-19. However, little has been said about oxidative stress status (OSS) of COVID-19 patients hospitalized in intensive care unit (ICU). Material and Methods: Biomarkers of the systemic OSS included antioxidants (9 assays), trace elements (3 assays), inflammation markers (4 assays) and oxidative damage to lipids (3 assays). Results: Blood samples were drawn after 9 (7–11) and 41 (39–43) days of ICU stay, respectively in 3 and 6 patients. Vitamin C, thiol proteins, reduced glutathione, γ-tocopherol, β-carotene and PAOT® score were significantly decreased compared to laboratory reference values. Selenium concentration was at the limit of the lower reference value. By contrast, the copper/zinc ratio (as a source of oxidative stress) was higher than reference values in 55% of patients while copper was significantly correlated with lipid peroxides (r = 0.95, p < 0.001). Inflammatory biomarkers (C-reactive protein and myeloperoxidase) were significantly increased when compared to normals. Conclusions: The systemic OSS was strongly altered in critically ill COVID-19 patients as evidenced by increased lipid peroxidation but also by deficits in some antioxidants (vitamin C, glutathione, thiol proteins) and trace elements (selenium).
Bay Leaf (Laurus Nobilis L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status
Authors: Brinza Ion , Boiangiu Razvan Stefan , Hancianu Monica , Cioanca Oana , Erdogan Orhan Ilkay , Hritcu Lucian
Published: February 2021

Bay leaf (Laurus nobilis L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activity, anticonvulsant activity, antimutagenic activity, and analgesic and anti-inflammatory activity. The present study aimed to investigate whether the bay leaf incense (BL) elicits the memory formation via the action on the cholinergic system using a scopolamine (Sco)-induced rat model. Rats were exposed to BL over 5 min in a smoking chamber apparatus once daily for 22 days, whereas memory impairment was induced by Sco (0.7 mg/kg), a muscarinic receptor antagonist, delivered 30 min before each behavioral test. The phytochemical composition of BL was achieved by gas chromatograph–mass spectrometry (GCMS). Behavioral effects in rats were assessed by Y-maze, radial arm maze (RAM), and novel object recognition (NOR) paradigms. Additionally, the acetylcholinesterase (AChE) activity and the oxidative stress markers in the rat hippocampus were also evaluated. Exposure to BL significantly ameliorated Sco-induced cognitive impairment and oxidative stress in the rat hippocampus. The obtained results suggested that BL-induced ameliorative cognitive effects are mediated by enhancement of the cholinergic system and antioxidant activities.
Characteristics of the Oxidative Status in Dairy Calves Fed at Different Milk Replacer Levels and Weaned at 14 Weeks of Age
Authors: Seibt Katharina Diana , Ghaffari Morteza Hosseini , Scheu Theresa , Koch Christian , Sauerwein Helga
Published: February 2021

A paradigm shift in the way of rearing heifer calves from restricted feeding and early weaning towards greater feed allowances and later weaning ages is ongoing. We aimed at characterizing the oxidative status in Holstein heifer calves fed with milk replacer (MR) at either a restrictive (RES) or a high (HIGH) level for 14 weeks. We compared two groups: HIGH (10 L MR/d, n = 18) and RES (5.7 L/d, n = 19) from day five until week 14 of life. In blood samples collected at birth, and then fortnightly from week 8–16, and in week 20, the antioxidative capacity measured as ferric reducing ability of plasma (FRAP), oxidative damage of lipids measured as thiobarbituric acid reactive substances (TBARS) and oxidative damage of proteins measured as advanced oxidation products of proteins (AOPP), free radicals measured as reactive oxidative metabolites (dROM), and the glutathione peroxidase (GSH-Px) activity, as well as leptin, adiponectin and haptoglobin were assessed. The time course of these variables during the first 20 weeks of life showed characteristic patterns; group differences were limited to adiponectin, AOPP, and FRAP. RES calves had lower growth rates, showed signs of hunger, but did not differ from HIGH in their intake of solid starter feed and in health status. This work characterizes the changes in oxidative status of dairy calves with increasing age and confirms the benefits of a high feeding plane with regard to welfare and development.
Nutraceuticals against Oxidative Stress in Autoimmune Disorders
Authors: Mannucci Carmen , Casciaro Marco , Sorbara Emanuela Elisa , Calapai Fabrizio , Di Salvo Eleonora , Pioggia Giovanni , Navarra Michele , Calapai Gioacchino , Gangemi Sebastiano
Published: February 2021

Antioxidant mechanisms are constituted of enzymes, endogenous, and non-enzymatic, exogenous, which have the role of counterbalancing oxidative stress. Intake of these compounds occurs in the diet. Vegetables, plants, and fruits contain a wide range of alkaloids, polyphenols, and terpenoids which are called “phytochemicals”. Most of these substances are responsible for the positive properties of fruits and vegetables, which are an essential part of a healthy life with roles in ameliorating chronic illnesses and favoring longevity. Nutraceuticals are substances contained in a food or fragment of it influencing health with positive effects on health helping in precenting or treating disorders. We conducted a review illustrating the principal applications of nutraceuticals in autoimmune disorders. Literature reported several studies about exogenous dietary antioxidant supplementation in diverse autoimmune diseases such as rheumatoid arthritis, lupus, diabetes, and multiple sclerosis. In these pathologies, promising results were obtained in some cases. Positive outcomes were generally associated with a reduction of oxidative stress parameters and a boost to antioxidant systems, and sometimes with anti-inflammatory effects. The administration of exogenous substances through food derivates or dietary supplements following scientific standardization was demonstrated to be effective. Further bias-free and extended studies should be conducted that include ever-increasing oxidative stress biomarkers.
Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans
Authors: Li Pan , Wang Zehua , Lam Sin Man , Shui Guanghou
Published: February 2021

Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C. elegans. The beneficial effects of Reb A were principally mediated via reducing the level of cellular reactive oxygen species (ROS) in response to oxidative stress and attenuating neutral lipid accumulation with aging. Transcriptomics analysis presented maximum differential expression of genes along the target of rapamycin (TOR) signaling pathway, which was further confirmed by quantitative real-time PCR (qPCR); while lipidomics uncovered concomitant reductions in the levels of phosphatidic acids (PAs), phosphatidylinositols (PIs) and lysophosphatidylcholines (LPCs) in worms treated with Reb A. Our results suggest that Reb A attenuates aging by acting as effective cellular antioxidants and also in lowering the ectopic accumulation of neutral lipids.
Stiffness Estimation and Equivalence of Boundary Conditions in FEM Models
Authors: Huňady Róbert , Lengvarský Pavol , Pavelka Peter , Kaľavský Adam , Mlotek Jakub
Published: February 2021

The paper deals with methods of equivalence of boundary conditions in finite element models that are based on finite element model updating technique. The proposed methods are based on the determination of the stiffness parameters in the section plate or region, where the boundary condition or the removed part of the model is replaced by the bushing connector. Two methods for determining its elastic properties are described. In the first case, the stiffness coefficients are determined by a series of static finite element analyses that are used to obtain the response of the removed part to the six basic types of loads. The second method is a combination of experimental and numerical approaches. The natural frequencies obtained by the measurement are used in finite element (FE) optimization, in which the response of the model is tuned by changing the stiffness coefficients of the bushing. Both methods provide a good estimate of the stiffness at the region where the model is replaced by an equivalent boundary condition. This increases the accuracy of the numerical model and also saves computational time and capacity due to element reduction.
Experimental Study on Backflow Patterns Induced by a Bilateral Groin Pair with Different Spacing
Authors: Kuang Cuiping , Zheng Yuhua , Gu Jie , Zou Qingping , Han Xuejian
Published: February 2021

Groins are one of the popular manmade structures to modify the hydraulic flow and sediment response in river training. The spacing between groins is a critical consideration to balance the channel-depth and the cost of construction, which is generally determined by the backflow formed downstream from groins. A series of experiments were conducted using Particle Image Velocimetry (PIV) to observe the influence of groin spacing on the backflow pattern of two bilateral groins. The spacing between groins has significant effect on the behavior of the large-scale recirculation cell behind groins. The magnitude of the wake flow induced by a groin was similar to that induced by another groin on the other side, but the flow direction is opposite. The spanwise velocity near the groin tip dictates the recirculation zone width behind the groins due to the strong links between the spanwise velocity and the contraction ratio of channel cross-sections between groins. Based on previous studies and present experimental results, quantitative empirical relationships are proposed to calculate the recirculation zone length behind groins alternately placed at different spacing along riverbanks. This study provides better understanding and a robust formula to assess the backflow extent of alternate groins and identify the optimum groins array configuration.
Influence of Edentulous Conditions on Intraoral Scanning Accuracy of Virtual Interocclusal Record in Quadrant Scan
Authors: Lee Ye-Chan , Kim Jong-Eun , Nam Na-Eun , Shin Seung-Ho , Lim Jung-Hwa , Lee Keun-Woo , Shim June-Sung
Published: February 2021

Reproduction of the exact interocclusal relationship using digital workflow is crucial for precise fabrication of accurate prostheses. Intraoral scanner is known to be valid for the measurement of quadrants, however, the role of missing area in the quadrant scan on the virtual interocclusal record (VIR) is uncertain. This study aimed to evaluate the accuracy of VIR in quadrant scans using an intraoral scanner (IOS) under four different edentulous conditions. Eight scans per group were obtained using a laboratory scanner and three IOSs (Trios3, CS3600, i500). Based on trueness and precision, Trios3 had the best results, followed by CS3600 and i500. The trueness and precision were affected by edentulous conditions. The three IOSs showed deviation in the posterior region during assessment of VIR for the missing area with posterior support. CS3600 and i500 showed deviation in the short-span edentulous area without support. In extended edentulous condition without support, Trios3 showed overclosure, while i500 showed an angular deviation. In some groups scanned with Trios3 and i500, the tilting effect was observed. Based on the edentulous condition and type of IOS used, local or general deviations in occlusion were seen. The accuracy of VIR was dependent on accurate scan data. Thus, registration of the occlusal relationship in an edentulous area with more than two missing teeth using IOSs may be clinically more inaccurate than that with a laboratory scanner.
Towards Phase Change Materials for Thermal Energy Storage: Classification, Improvements and Applications in the Building Sector
Authors: Podara Christina V. , Kartsonakis Ioannis A. , Charitidis Costas A.
Published: February 2021

The management of energy consumption in the building sector is of crucial concern for modern societies. Fossil fuels’ reduced availability, along with the environmental implications they cause, emphasize the necessity for the development of new technologies using renewable energy resources. Taking into account the growing resource shortages, as well as the ongoing deterioration of the environment, the building energy performance improvement using phase change materials (PCMs) is considered as a solution that could balance the energy supply together with the corresponding demand. Thermal energy storage systems with PCMs have been investigated for several building applications as they constitute a promising and sustainable method for reduction of fuel and electrical energy consumption, while maintaining a comfortable environment in the building envelope. These compounds can be incorporated into building construction materials and provide passive thermal sufficiency, or they can be used in heating, ventilation, and air conditioning systems, domestic hot water applications, etc. This study presents the principles of latent heat thermal energy storage systems with PCMs. Furthermore, the materials that can be used as PCMs, together with the most effective methods for improving their thermal performance, as well as various passive applications in the building sector, are also highlighted. Finally, special attention is given to the encapsulated PCMs that are composed of the core material, which is the PCM, and the shell material, which can be inorganic or organic, and their utilization inside constructional materials.
A Novel Methodology for Hydrocarbon Depth Prediction in Seabed Logging: Gaussian Process-Based Inverse Modeling of Electromagnetic Data
Authors: Daud Hanita , Mohd Aris Muhammad Naeim , Mohd Noh Khairul Arifin , Dass Sarat Chandra
Published: February 2021

Seabed logging (SBL) is an application of electromagnetic (EM) waves for detecting potential marine hydrocarbon-saturated reservoirs reliant on a source–receiver system. One of the concerns in modeling and inversion of the EM data is associated with the need for realistic representation of complex geo-electrical models. Concurrently, the corresponding algorithms of forward modeling should be robustly efficient with low computational effort for repeated use of the inversion. This work proposes a new inversion methodology which consists of two frameworks, namely Gaussian process (GP), which allows a greater flexibility in modeling a variety of EM responses, and gradient descent (GD) for finding the best minimizer (i.e., hydrocarbon depth). Computer simulation technology (CST), which uses finite element (FE), was exploited to generate prior EM responses for the GP to evaluate EM profiles at “untried” depths. Then, GD was used to minimize the mean squared error (MSE) where GP acts as its forward model. Acquiring EM responses using mesh-based algorithms is a time-consuming task. Thus, this work compared the time taken by the CST and GP in evaluating the EM profiles. For the accuracy and performance, the GP model was compared with EM responses modeled by the FE, and percentage error between the estimate and “untried” computer input was calculated. The results indicate that GP-based inverse modeling can efficiently predict the hydrocarbon depth in the SBL.
Bioengineered Skin Substitutes: Advances and Future Trends
Authors: Tavakoli Shima , Klar Agnes S.
Published: February 2021

As the largest organ in the human body, the skin has the function of maintaining balance and protecting from external factors such as bacteria, chemicals, and temperature. If the wound does not heal in time after skin damage, it may cause infection or life-threatening complications. In particular, medical treatment of large skin defects caused by burns or trauma remains challenging. Therefore, human bioengineered skin substitutes represent an alternative approach to treat such injuries. Based on the chemical composition and scaffold material, skin substitutes can be classified into acellular or cellular grafts, as well as natural-based or synthetic skin substitutes. Further, they can be categorized as epidermal, dermal, and composite grafts, based on the skin component they contain. This review presents the common commercially available skin substitutes and their clinical use. Moreover, the choice of an appropriate hydrogel type to prepare cell-laden skin substitutes is discussed. Additionally, we present recent advances in the field of bioengineered human skin substitutes using three-dimensional (3D) bioprinting techniques. Finally, we discuss different skin substitute developments to meet different criteria for optimal wound healing.
Criticality Analysis for BWR Spent Fuel Based on the Burnup Credit Evaluation from Full Core Simulations
Authors: Detkina Anna , Litskevitch Dzianis , Peakman Aiden , Merk Bruno
Published: February 2021

This study performed criticality analysis for the GBC-68 storage cask loaded with boiling water reactor (BWR) spent fuel at the discharged burnups obtained from the full-core simulations. The analysis was conducted for: (1) different reloading scenarios; (2) target burnups; and (3) two fuel assembly types—GE14 and SVEA100—to estimate the impact each of the three factors has on the cask reactivity. The BWR spent fuel composition was estimated using the results of the nodal analysis for the advanced boiling water reactor (ABWR) core model developed in this study. The nodal calculations provided realistic operating data and axial burnup and coolant density profiles, for each fuel assembly in the reactor core. The estimated cask’s keff were compared with the fresh fuel and peak reactivity standards to identify the benefit of the burnup credit method applied to the BWR spent fuel at their potential discharge burnups. The analysis identified the significant cask criticality reduction from employing the burnup credit approach compared to the conventional fresh fuel approach. However, the criticality reduction was small compared to the peak reactivity approach, and could even disappear for low burnt fuel assemblies from non-optimal reloading patterns. In terms of cask manufacturing, the potential financial benefit from using the burnup credit approach was estimated to be USD 3.3 million per reactor cycle.
All-Optical Non-Inverted Parity Generator and Checker Based on Semiconductor Optical Amplifiers
Authors: Han Bingchen , Xu Junyu , Chen Pengfei , Guo Rongrong , Gu Yuanqi , Ning Yu , Liu Yi
Published: February 2021

An all-optical non-inverted parity generator and checker based on semiconductor optical amplifiers (SOAs) are proposed with four-wave mixing (FWM) and cross-gain modulation (XGM) non-linear effects. A 2-bit parity generator and checker using by exclusive NOR (XNOR) and exclusive OR (XOR) gates are implemented by first SOA and second SOA with 10 Gb/s return-to-zero (RZ) code, respectively. The parity and check bits are provided by adjusting the center wavelength of the tunable optical bandpass filter (TOBPF). A saturable absorber (SA) is used to reduce the negative effect of small signal clock (Clk) probe light to improve extinction ratio (ER) and optical signal-to-noise ratio (OSNR). For Pe and Ce (even parity bit and even check bit) without Clk probe light, ER and OSNR still maintain good performance because of the amplified effect of SOA. For Po (odd parity bit), ER and OSNR are improved to 1 dB difference for the original value. For Co (odd check bit), ER is deteriorated by 4 dB without SA, while OSNR is deteriorated by 12 dB. ER and OSNR are improved by about 2 dB for the original value with the SA. This design has the advantages of simple structure and great integration capability and low cost.
Biomechanics Perspective for the Design and Manufacture of Continuous Ambulatory Peritoneal Dialysis Connectors
Authors: Grave-Capistrán Mario Alberto , Aguilar-Pérez Luis Antonio , Paredes-Rojas Juan Carlos , De la Cruz-Alejo Carlos , Torres-SanMiguel Christopher René
Published: February 2021

Chronic kidney disease (CKD) progressively and irreversibly affects the kidneys and is considered a catastrophic disease on a global scale. Continuous ambulatory peritoneal dialysis (CAPD) is one of the most used methods of treatment, involving infusion and draining bags and a transfer line. Patients receiving this treatment have a catheter that is placed during surgery; this depends on having the same catheter supplies, as they are not compatible with other market brands. This research shows the comparison between connector brands used at the outlet of the Tenckhoff® catheter. The methodology shows the design of two connectors using the 3D printing technique. Numerical simulations were carried out to establish the flow patterns through each of the designs; the maximum values of velocity reached 74 mm/s inside the PISA to Baxter (PB) connector, while the pressure and vorticity were controlled and did not represent failures inside the connectors and threads connections. An experimental testbed was designed to verify the connections between the manufactured devices and the market brand elements. The results show numerical and experimental comparisons of the developed titanium-ELI connectors with no leaks at the connection points due to the lack of commercial supplies. These connectors can be used in the treatment of CAPD.
Flexible Job Shop Scheduling Problem with Sequence Dependent Setup Time and Job Splitting: Hospital Catering Case Study
Authors: Abderrabi Fatima , Godichaud Matthieu , Yalaoui Alice , Yalaoui Farouk , Amodeo Lionel , Qerimi Ardian , Thivet Eric
Published: February 2021

This paper aims to study a real case of an optimization problem derived from a hospital supply chain. The present work focuses on developing operational decision support models and algorithms for production process scheduling in hospital catering. The addressed production system is considered as a flexible job shop system. The objective is to minimize the total flow time. A novel mathematical model and two metaheuristics for the production scheduling of multi-product and multi-stage food processes are developed. These methods have proven their effectiveness for the scheduling of operations of the food production processes and allowed significant improvements in the performance of the studied production system.
Improvement in the Convolutional Neural Network for Computed Tomography Images
Authors: Manabe Keisuke , Asami Yusuke , Yamada Tomonari , Sugimori Hiroyuki
Published: February 2021

Background and purpose. This study evaluated a modified specialized convolutional neural network (CNN) to improve the accuracy of medical images. Materials and Methods. We defined computed tomography (CT) images as belonging to one of the following 10 classes: head, neck, chest, abdomen, and pelvis with and without contrast media, with 10,000 images per class. We modified the CNN based on the AlexNet with an input size of 512 × 512. We resized the filter sizes of the convolution layer and max pooling. Using these modified CNNs, various models were created and evaluated. The improved CNN was evaluated to classify the presence or absence of the pancreas in the CT images. We compared the overall accuracy, which was calculated from images not used for training, to that of the ResNet. Results. The overall accuracies of the most improved CNN and ResNet in the 10 classes were 94.8% and 89.3%, respectively. The filter sizes of the improved CNN for the convolution layer were (13, 13), (7, 7), (5, 5), (5, 5), and (5, 5) in order from the first layer, and that of max-pooling was (7, 7). The calculation times of the most improved CNN and ResNet were 56 and 120 min, respectively. Regarding the classification of the pancreas, the overall accuracies of the most improved CNN and ResNet were 75.75% and 58.25%, respectively. The calculation times of the most improved CNN and ResNet were 36 and 55 min, respectively. Conclusion. By optimizing the filter size of the convolution layer and max-pooling of 512 × 512 images, we quickly obtained a highly accurate medical image classification model. This improved CNN can be useful for classifying lesions and anatomies for related diagnostic aid applications.
Mapping Spatial Distribution of Pores in an Additively Manufactured Gold Alloy Using Neutron Microtomography
Authors: Ghasemi-Tabasi Hossein , Trtik Pavel , Jhabvala Jamasp , Meyer Michael , Carminati Chiara , Strobl Markus , Logé Roland E.
Published: February 2021

A crucial criterion for the quality of the additively manufactured parts is the porosity content for achieving an acceptable final relative density. In addition, for jewelry applications, visible pores are unacceptable at or in the vicinity of the surface. In this study, non-destructive 3D neutron microtomography is applied to map the spatial distribution of pores in additively manufactured red-gold samples. The 3D imaging assessment underlines the high relative density of the printed red-gold sample and indicates residual pore sizes are predominantly below the limit of concern for jewelry applications. The 3D maps of pores within printed samples highlight the effect of the scanning strategy on the final quality and location of pores in the printed samples. These results confirm that neutron microtomography is a novel and precise tool to characterize residual porosity in additively manufactured gold alloys and other higher-Z materials where such investigation using other non-destructive methods (such as X-rays) is challenging due to the limited penetration depth.
Optical Technology for NFV Converged Networks
Authors: Iovanna Paola , Bigongiari Alessandra , Bianchi Alberto , Menezo Sylvie , Romagnoli Marco , Sorianello Vito , Cavaliere Fabio
Published: February 2021

5G and its evolution towards 6G is unlocking new use cases that will require the reconsideration of the existing network architectures and its operation. As the network will be required to support new service types and radio protocol splits, the traditional physical point to point connections will need to be replaced with a transport network up to the antenna site to guarantee low latency services and high bandwidth. Optical based transport is a key enabler to realize such a convergent network, where the traditional fixed infrastructure in use for mobile services and mobile infrastructure should also support enterprises services. The Software Defined Network (SDN) and Network Function Virtualization (NFV) technology plays a key role to evolve towards digitalization. It allows to simplify the creation of new services and to implement a real decoupling between the infrastructure and the network functions that run virtually, on generic processing units located everywhere in the network. Supporting automation is a key requirement that traditional optical technology is not able to meet. In this paper the reference scenarios for the access network are presented with the analysis of their requirements and the enabling optical solutions based on integrated silicon photonics.
Effect of Cellulose Characteristics on the Properties of the Wet-Spun Aerogel Fibers
Authors: Rostamitabar Matin , Seide Gunnar , Jockenhoevel Stefan , Ghazanfari Samaneh
Published: February 2021

Cellulose aerogels (CAs) from plant or bacterial-derived cellulose have advantages such as low density, high porosity, and high specific surface area and have been used in various applications including biomedical fields. One limiting factor in developing CAs is their demanding shaping process since it involves several steps of dissolution/dispersion of cellulose, geometry configurations using molds or nozzles, coagulation and washing of the gel body, and drying techniques. CA fibers can be converted into textiles and enhance the design ability, stiffness, and flexibility of the CAs. This study aims to understand the correlations between the initial cellulose characteristics, aerogel’s internal structure, and its prospective biomedical application. Wet-spun CA fibers were obtained by supercritical CO2 drying from low and high molecular weight microcrystalline cellulose in calcium thiocyanate tetrahydrate solution. Fiber spinning, thermal behavior, textural properties, and biological assessments of the CA fibers were inspected. The CA microfibers from high molecular weight cellulose proved to have a higher surface area (~197 m2/g), denser structure, and finer nanofibrils (~2 nm) with better thermal stability in comparison with the fibers produced from low molecular weight cellulose. The fibers were nontoxic, and cell proliferation was observed over time. CA fibers showed promising results to be used for biomedical applications such as tissue engineering and wound care.
Editorial for Special Issue “Virtual Reality and Its Application in Cultural Heritage”
Authors: Fidas Christos , Sylaiou Stella
Published: February 2021

Recent advancements in Virtual Reality (VR) technologies provide new opportunities for Cultural Heritage (CH) organizations to attract, engage, and support end-users more efficiently and effectively [...]
Purely Gain-Coupled Distributed-Feedback Bragg Semiconductor Laser Diode Emitting at 770 nm
Authors: Ruan Chunkao , Chen Yongyi , Qin Li , Jia Peng , Zeng Yugang , Song Yue , Lei Yuxin , Zhang Zhijun , Zhang Nan , Li Zaijin
Published: February 2021

The transition lines of Mg, K, Fe, Ni, and other atoms lie near 770 nm, therefore, this spectral region is important for helioseismology, solar atmospheric studies, the pumping of atomic clocks, and laser gyroscopes. However, there is little research on distributed-feedback (DFB) semiconductor lasing at 770 nm. In addition, the traditional DFB semiconductor laser requires secondary epitaxy or precision grating preparation technologies. In this study, we demonstrate an easily manufactured, gain-coupled DFB semiconductor laser emitting at 770 nm. Only micrometer scale periodic current injection windows were used, instead of nanoscale grating fabrication or secondary epitaxy. The periodically injected current assures the device maintains single longitudinal mode working in the unetched Fabry–Perot cavity under gain coupled mechanism. The maximum continuous-wave output power reached was 116.3 mW at 20 °C, the maximum side-mode-suppression ratio (SMSR) was 33.25 dB, and the 3 dB linewidth was 1.78 pm.
Using Domain-Specific Models to Facilitate Model-Based Systems-Engineering: Development Process Design Modeling with OPM and PROVE
Authors: Shaked Avi , Reich Yoram
Published: February 2021

Model-based Systems Engineering (MBSE) approaches are a step forward in the evolution of computer-aided engineering, and yet, they often incorporate deficiencies that may jeopardize their practical utility and usability, as well as the validity of the resulting models. We demonstrate how a domain-specific modeling approach can relieve some hurdles in adopting MBSE, and how it can be used in tandem with a general-purpose modeling approach to augment and introduce rigor to models. Specifically, we demonstrate the consequences of theoretical issues that were previously identified in Object Process Methodology and suggest an approach to solve them. We use a generalized case-study—derived from extensive process modeling in both academia and industry—to show that a domain-specific model can significantly relax the user’s modeling effort. This demonstration is based on two quantitative metrics: the number of representational elements and available modeling tactics. We discuss the contribution of our approach to model quality, particularly with respect to its rigor and communicability.
Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection
Authors: De Tollenaere Morgane , Chapuis Emilie , Auriol Pascale , Auriol Daniel , Scandolera Amandine , Reynaud Romain
Published: February 2021

One of the most visible signs of hair ageing is greying of the hair, also known as canities. This hair disorder is mainly caused by oxidative stress. In preliminary work, we designed various models mimicking the impact of oxidative stress on hair pigmentation, showing an accumulation of reactive oxygen species (ROS) production and a decrease in the presence of melanocytes and melanoblasts, resulting in a decrease in hair pigmentation. A proteomic study on skin scalp explants was performed to identify the dysregulated biological pathways related to canities. We developed a smart active ingredient which has been tested on these biological pathways. We demonstrated that these negative effects were rectified in the presence of the ingredient, showing a reduction of ROS, protection of melanocyte reservoirs and reactivation of hair pigmentation. Finally, a clinical study was carried out on a panel of 44 male volunteers with grey hair. After 4 months, we evidenced a reduction in the proportion of grey hair and in the number of grey hairs/cm2 relative to Day 0. In conclusion, we clearly evidenced that oxidative stress is a key factor in triggering a cascade of events leading to a loss of hair pigmentation. We developed this active ingredient which is capable of restoring all the disrupted mechanisms and of providing hair repigmentation within only 4 months.
Effects of Low-Intensity Resistance Exercise with Slow Movement and Tonic Force Generation on Short-Term Glycemic Variability in Healthy Subjects: A Randomized Controlled Study
Authors: Shoji Takuro , Hamasaki Hidetaka , Kawaguchi Akiko , Waragai Yoko , Yanai Hidekatsu
Published: February 2021

Resistance exercise improves daily glycemic control. Low-intensity resistance exercise with slow movements and tonic force generation (LST) is a resistance exercise protocol that can increase skeletal muscle mass and strength without considerable physical burden; however, its effect on glycemic variability is unknown. The aim of this study was to investigate the effect of LST on short-term glycemic variability, expressed as the M-value, in healthy individuals. We recruited 20 healthy subjects (mean age: 27.9 ± 3.9 years) with normal glucose tolerance, and subjects were randomly assigned to the control (n = 10) or LST (n = 10) groups. Subjects in the LST group performed the resistance exercise with 40–50% of the one-repetition maximum for 40 min. All subjects wore a subcutaneous continuous glucose monitoring system and a triaxial accelerometer, and their daily glycemic variability and physical activity were measured. One hour after the intervention, in the LST group, the variability of blood glucose levels was significantly decreased compared to the control group (M-values in the LST group: pre 3.5 ± 6.2, post 2.7 ± 2.7, p = 0.575; M-values in the control group: pre 0.4 ± 0.7, post 2.7 ± 2.0, p = 0.017). However, there were no differences in total physical activity and daily glycemic control between groups. The findings of this study suggest that LST improves short-term glycemic variability in healthy subjects.
Effects of Bulk Flow Pulsations on Film Cooling with Two Sister Holes
Authors: Baek Seung Il , Ahn Joon
Published: February 2021

In a triple-hole system comprising a primary hole and two sister holes, when the sister holes are positioned slightly downstream of the main hole under steady flow conditions, their jets generate an anti-counter-rotating vortex pair. Vortex interactions between the jets increase the effectiveness of adiabatic film cooling. In this study, a series of large-eddy simulations were conducted to understand how pulsations in the main flow affect film cooling in a triple hole. To understand the effects of pulsations on film cooling performance is important for better cooling design of the gas turbine engines. The numerical simulations were carried out on a flat plate geometry with a triple cylindrical hole system at 35° injection angle. The pulsations were approximately sinusoidal, and their effect on film cooling was investigated at several frequencies (2, 16, and 32 Hz) and Strouhal numbers (Sr = 0.1005, 0.8043, and 1.6085) at an average blowing ratio of 0.5. The results for the triple-hole system were compared with those for a single hole for the same amount of cooling air and the same cross-sectional area of the holes. Increasing the Strouhal number of the main flow decreased η in both systems. However, at each Strouhal number, η was higher in the triple hole. Furthermore, the triple-hole system was found to be better for film cooling than a single-hole system for higher values of the pulsation Strouhal number. Contours of time-averaged film cooling effectiveness and dimensionless temperature, instantaneous film cooling effectiveness contours on a test plate, mean velocity magnitude contours in the hole, and Q-contours for the triple holes under the application of pulsations to the flow were investigated.
Coordinated Control Strategy of CU-MTDC under Abnormal Conditions Considering Power Supply Security
Authors: Wang Zhuodi , Li Kejun , Liang Jun , Sun Kaiqi , Wang Jinyu , Liu Zhijie
Published: February 2021

The coastal urban multi-terminal DC (CU-MTDC) is a prospective solution for enhancing the power supply security of the coastal urban power (CUP) grid and integrating the large-scale offshore wind farm. However, the large DC disturbances may significantly impact the CUP power supply security. The existing DC unbalanced power distribution methods are difficult to be applied in the CU-MTDC because of the complicated optimization process and the expansion of the influence range of a DC fault. To solve the above problems, this paper proposes a coordinated control strategy of CU-MTDC under abnormal conditions. First, calculation principles for the active power reference of center coastal urban power (CCUP) grid converters are proposed. Second, a DC unbalanced power coordinated distribution strategy under abnormal conditions is used based on the dynamic priority control to ensure power supply security of the critical AC lines. Third, the controller parameters of CCUP grid converters are calculated. Through a simple control process, the number of the regulation converters is dynamically scheduled according to the DC unbalanced power. The DC fault influence range on the urban power grid can be limited in a sufficiently small area. Simulation verified the effectiveness of the proposed control strategy.
Design and Evaluation of a Web- and Mobile-Based Binaural Audio Platform for Cultural Heritage
Authors: Comunità Marco , Gerino Andrea , Lim Veranika , Picinali Lorenzo
Published: February 2021

PlugSonic is a suite of web- and mobile-based applications for the curation and experience of 3D interactive soundscapes and sonic narratives in the cultural heritage context. It was developed as part of the PLUGGY EU project (Pluggable Social Platform for Heritage Awareness and Participation) and consists of two main applications: PlugSonic Sample, to edit and apply audio effects, and PlugSonic Soundscape, to create and experience 3D soundscapes for headphones playback. The audio processing within PlugSonic is based on the Web Audio API and the 3D Tune-In Toolkit, while the mobile exploration of soundscapes in a physical space is obtained using Apple’s ARKit. The main goal of PlugSonic is technology democratisation; PlugSonic users—whether cultural institutions or citizens—are all given the instruments needed to create, process and experience 3D soundscapes and sonic narratives; without the need for specific devices, external tools (software and/or hardware), specialised knowledge or custom development. The aims of this paper are to present the design and development choices, the user involvement processes as well as a final evaluation conducted with inexperienced users on three tasks (creation, curation and experience), demonstrating how PlugSonic is indeed a simple, effective, yet powerful tool.
Metamaterial Based Design of Compact UWB/MIMO Monopoles Antenna with Characteristic Mode Analysis
Authors: Jabire Adamu Halilu , Ghaffar Adnan , Li Xue Jun , Abdu Anas , Saminu Sani , Alibakhshikenari Mohammad , Falcone Francisco , Limiti Ernesto
Published: February 2021

In this article, a novel metamaterial inspired UWB/multiple-input-multiple-output (MIMO) antenna is presented. The proposed antenna consists of a circular metallic part which formed the patch and a partial ground plane. Metamaterial structure is loaded at the top side of the patches for bandwidth improvement and mutual coupling reduction. The proposed antenna provides UWB mode of operation from 2.6–12 GHz. The characteristic mode theory is applied to examine each physical mode of the antenna aperture and access its many physical parameters without exciting the antenna. Mode 2 was the dominant mode among the three modes used. Considering the almost inevitable presence of mutual coupling effects within compact multiport antennas, we developed an additional decoupling technique in the form of perturbed stubs, which leads to a mutual coupling reduction of less than 20 dB. Finally, different performance parameters of the system, such as envelope correlation coefficient (ECC), channel capacity loss (CCL), diversity gain, total active reflection coefficient (TARC), mean effective gain (MEG), surface current, and radiation pattern, are presented. A prototype antenna is fabricated and measured for validation.
Simple Approach for Evaluation of Abrasive Mixing Efficiency for Abrasive Waterjet Rock Cutting
Authors: Cha Yohan , Oh Tae-Min , Hwang Hyun-Joong , Cho Gye-Chun
Published: February 2021

The abrasive mixing variables, such as the abrasive and water flow rates and the focus geometry parameters, determine the profitability of an abrasive waterjet system. In this study, the mixing efficiency characteristics in abrasive waterjet rock cutting were investigated. To demonstrate comprehensively the efficiency reduction due to collision during abrasive mixing, the chance of collision was expressed as the distance between the abrasive particles in the focus. The mixing efficiency was then assessed by utilizing the empirical relationship between the experimental results and the developed model. Based on the particle density and the velocity, the closer particles showed higher chances of collision, thus yielding a reduced cutting performance. Using the distance between particles model, the optimum abrasive flow rate and the cutting performance of abrasive waterjet systems can be estimated. This developed model can be used for the design selection of abrasive flow rate and systems for the cost-effective use of abrasive waterjets.
Comparative Study of Anti-Inflammatory Effect on DSS-Induced Ulcerative Colitis Between Novel Glycyrrhiza Variety and Official Compendia
Authors: Kang Sa-Haeng , Song Young-Jae , Jeon Yong-Deok , Kim Dong-Keun , Park Jeong-Hyang , Soh Ju-Ryoun , Lee Jong-Hyun , Kitalong Christopher , Kim Wonnam , An Hyo-Jin , Chang Jae-Ki , Lee Jeonghoon , Jin Jong-Sik
Published: February 2021

Glycyrrhizae radix (GR), a plant commonly referred to as licorice, is used as a medicine and food worldwide. However, the utilization of GR from wild areas has caused desertification and a depletion of natural resources. Environmental restrictions and low productivity have limited plant cultivation. For this reason, an improved Glycyrrhiza variety, Wongam (WG), in cultivation and quality has been developed by Korea Rural Development Administration. To evaluate the equivalence of efficacy, several comparative studies between already-registered species and new cultivars have been conducted. This study evaluated the anti-inflammatory effect of WG extracts in a dextran sulfate sodium (DSS)-induced colitis model, in comparison to that of GR extracts. WG extract significantly improved the clinical signs of DSS-induced ulcerative colitis, including disease activity index, body weight loss, and colon length shortening, which was equivalent to the effect of GR. Furthermore, the fecal microbiota was analyzed by terminal restriction fragment length polymorphism. The composition of the fecal microbiota did not show a specific pattern based on experimental groups; however, a tendency toward an increase in the proportion of Lactobacillales was observed. These findings showed an equivalence of efficacy and the possible utilization of WG as a medicinal resource with already-registered species.