bluuebunny/crossref_metadata_2025 huggingface dataset:
Metagenomics coupled with biogeochemical rates measurements provide evidence that nitrate addition stimulates respiration in salt marsh sediments
Authors: Bulseco Ashley N. , Vineis Joseph H. , Murphy Anna E. , Spivak Amanda C. , Giblin Anne E. , Tucker Jane , Bowen Jennifer L.
Published: October 2019

High‐throughput sequencing has enabled robust shotgun metagenomic sequencing that informs our understanding of the genetic basis of important biogeochemical processes. Slower to develop, however, are the application of these tools in a controlled experimental framework that pushes the field beyond exploratory analysis toward hypothesis‐driven research. We performed flow‐through reactor experiments to examine how salt marsh sediments from varying depths respond to nitrate addition and linked biogeochemical processes to this underlying genetic foundation. Understanding the mechanistic basis of carbon and nitrogen cycling in salt marsh sediments is critical for predicting how important ecosystem services provided by marshes, including carbon storage and nutrient removal, will respond to global change. Prior to the addition of nitrate, we used metagenomics to examine the functional potential of the sediment microbial community that occurred along a depth gradient, where organic matter reactivity changes due to decomposition. Metagenomic data indicated that genes encoding enzymes involved in respiration, including denitrification, were higher in shallow sediments, and genes indicative of resource limitation were greatest at depth. After 92 d of nitrate enrichment, we measured cumulative increases in dissolved inorganic carbon production, denitrification, and dissimilatory nitrate reduction to ammonium; these rates correlated strongly with genes that encode essential enzymes in these important pathways. Our results highlight the importance of controlled experiments in linking biogeochemical rates to underlying genetic pathways. Furthermore, they indicate the importance of nitrate as an electron acceptor in fueling microbial respiration, which has consequences for carbon and nitrogen cycling and fate in coastal marine systems.
An ultrawideband and conformal antenna for wireless capsule endoscopy
Authors: Shang Jiangli , Yu Ying
Published: October 2019

In this article, a conformal antenna with ultrawideband performance is presented for wireless endoscopy applications, operating in industrial scientific, and medical (ISM, 433.1‐434.8 MHz) band. Rigid materials with high dielectric constants are typically used as substrates for implantable inverted‐F antennas (IFAs), but they are not suitable for conformal configurations. In contrast to this, the proposed antenna adopts flexible polyimide as its substrate. The original IFA is designed with a fundamental resonance in the lower band. By embedding an open‐slot between the short point and the feeding point, an additional resonance is excited, simultaneously moving toward the fundamental resonance, thereby achieving a simulation bandwidth of 100%. Finally, the proposed antenna is measured in pork.
Bidirectional evolutionary structural optimization for nonlinear structures under dynamic loads
Authors: Shobeiri Vahid
Published: October 2019

This study aims to develop efficient numerical optimization methods for finding the optimal topology of nonlinear structures under dynamic loads. The numerical models are developed using the bidirectional evolutionary structural optimization method for stiffness maximization problems with mass constraints. The mathematical formulation of topology optimization approach is developed based on the element virtual strain energy as the design variable and minimization of compliance as the objective function. The suitability of the proposed method for topology optimization of nonlinear structures is demonstrated through a series of two‐ and three‐dimensional benchmark designs. Several issues relating to the nonlinear structures subjected to dynamic loads such as material, geometric, and contact nonlinearities are addressed in the examples. It is shown that the proposed approach generates more reliable designs for nonlinear structures.
ToF‐SIMS depth profiling of oral drug delivery films for 3D visualization of active pharmaceutical particles
Authors: Muramoto Shin , Gillen Greg , Collett Cayla , Zeissler Cynthia J. , Garboczi Edward J.
Published: October 2019

The size, shape, and spatial distribution of active pharmaceutical ingredient (API) are important physical characteristics of drug delivery systems that can affect the performance, stability, appearance, and even bulk properties of the end product. This study explores the feasibility of using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) for the 3D characterization of API particles in two commercially available oral dissolvable drug delivery films. It was found that ToF‐SIMS imaging with argon gas cluster ion beam (GCIB) sputtering allowed production of 3D chemical maps that could be utilized to obtain size distributions of buprenorphine particles whose effective diameters ranged from approximately 6 μm to 41 μm, with shapes that were generally spherical with a few nonspherical structures. The particles were heterogeneously distributed both laterally and as a function of depth in the film. In addition, ToF‐SIMS was able to differentiate between different oral drug delivery films based on differences in the spatial distribution of buprenorphine; in one case, the particles were distributed throughout the depth of the film, whereas the particles in the other case were localized close to the surface. Preliminary studies suggest that ToF‐SIMS with argon GCIB sputtering may also allow us to provide a very rough estimate of the concentration of the APIs (factors of 2 to 4), namely buprenorphine and naloxone, at pharmacologically relevant concentrations inside organic drug delivery systems with a thickness of hundreds of micrometers.
An investigation on requirement and objective allocation strategies using a principal–agent model
Authors: Vermillion Sean D. , Malak Richard J.
Published: October 2019

In this paper, we investigate the dichotomy between system design delegation driven by requirement allocation and delegation driven by objective allocation. Specifically, we investigate this dichotomy through the lens of agency theory, which addresses cases where an agent makes decisions on behalf of another, that is, a principal. In current practice, design delegation largely involves requirement allocation as a means to inform agents of the desirable system characteristics. The value‐driven design paradigm proposes replacing requirements with objective, or trade‐off, functions to better guide agents toward optimal systems. We apply and adapt the principal–agent mathematical model to the design delegation problem to determine if a principal, that is, the delegator, should communicate using requirements or objectives with her agent. In this model, we assume the case of a single principal and single agent where the agent has certain domain knowledge the principal does not have and the agent accrues costs while solving a delegated design problem. Under the assumptions of the mathematical model, we show that the requirement allocation paradigm can yield greater value to the principal over objective despite limitations requirement allocation places on the principal to learn information from the agent. However, relaxing model assumptions can impact the value proposition of requirement allocation in favor of objective allocation. Therefore, a resolution to the requirement–objective dichotomy may be context dependent. The results and the analytical framework used to derive them provide a new, foundational perspective with which to investigate allocation strategies.
Role of pyrophosphate on the degradation of sulfamethoxazole by permanganate combined with different reductants: Positive or negative
Authors: Liu Weifan , Yin Daqiang , Guan Xiaohong , Rao Dandan , Cao Guomin , Sun Yuankui
Published: October 2019

Activating permanganate with reductants has gained increasing attention recently for efficient organic contaminants abatement via reactive intermediate Mn species. However, few studies have been conducted to explore the role of pyrophosphate (PP), a typical complexing agent for intermediate Mn species, in activated permanganate systems. In this study, taking sulfamethoxazole (SMX) as a probe compound, the influences of PP on SMX degradation by permanganate/thiosulfate and permanganate/hydroxylamine were extensively studied. It was found that both thiosulfate and hydroxylamine were able to activate permanganate for oxidation of SMX in the absence of PP. However, upon the introduction of PP, opposite effects were observed in the two systems where PP further improved the activation of permanganate by thiosulfate but dampened the performance of permanganate/hydroxylamine markedly. For permanganate/hydroxylamine system, MnO2 was determined to be the only reactive oxidative species accounting for SMX degradation in the absence of PP, and its generation could be completely inhibited by PP. While in permanganate/thiosulfate system, both Mn(V) and MnO2 were responsible for SMX oxidation, and the introduction of PP could strengthen the oxidative ability of Mn(V). These results could shed some insights on the suitability of applying PP to explore the kinetics and mechanisms of manganese involved redox reactions.

Practitioner points

Both Na2S2O3 and NH2OH·HCl can activate KMnO4 for SMX removal without PP.

MnO2 is the reactive oxidative species involved in KMnO4/NH2OH·HCl system.

Mn(V) and MnO2 account for the SMX oxidation by KMnO4/Na2S2O3 system.

PP could inhibit the formation of MnO2 but enhance the oxidative ability of Mn(V).
Cover Image, Volume 11, Issue 6
Authors: Chen Liang , Zhou Xiaojun , He Chuanglong
Published: October 2019

The cover image is based on the Advanced Review Mesoporous silica nanoparticles for tissue‐engineering applications, by Liang Chen, Xiaojun Zhou, Chuanglong He. https://doi.org/10.1002/wnan.1573

image
A note on inhomogeneous ground states at large global charge
Authors: Hellerman Simeon , Kobayashi Nozomu , Maeda Shunsuke , Watanabe Masataka
Published: October 2019

Abstract

In this note we search for the ground state of the D = 3 Wilson-Fisher conformal O(4) model, at nonzero values of the two independent charge densities ρ
1,2, on the torus spatial slice. Using an effective theory valid on scales longer than the scale defined by the charge density, we show that the ground-state configuration is inhomogeneous for generic ratios ρ
1/ρ
2. This result confirms, within the context of a well-defined effective theory, a recent no-go result of [1]. We also show that any spatially periodic ground state solutions have an energetic preference towards longer periods, within some range of ρ
1/ρ
2 containing a neighborhood of zero. This suggests that the scale of variation of the ground state solution in finite volume will be the infrared scale, and that the use of the effective theory at large charge in finite volume is self-consistent. Note added: the statements in this paper are true for arbitrary ratio of ρ
1/ρ
2, which we proved after we uploaded this paper. See [2].
Seeking help for sexual difficulties: findings from a study with older adults in four European countries
Authors: Hinchliff Sharron , Carvalheira Ana Alexandra , Štulhofer Aleksandar , Janssen Erick , Hald Gert Martin , Træen Bente
Published: October 2019

Sexual well-being is an important part of life for many people aged 60 and older. However, older adults often face barriers to seeking and receiving help for sexual difficulties. This study used data from a probability survey (n = 3820) on sexuality and ageing to examine help-seeking in 60–75-year-olds in Norway, Denmark, Belgium, and Portugal. More men (12.2%) than women (6.8%) had sought professional help for a sexual difficulty in the past 5 years. The main reason for help-seeking was that sex was important to the participant and/or their relationship. The main source of professional help was the primary care physician. Of those who had sought professional help, 48% were satisfied or very satisfied with the help received, 31.6% were neither satisfied nor dissatisfied, and 20.4% were dissatisfied or very dissatisfied. Others had sought help from informal sources, particularly partners, friends, or websites. The main reasons for not seeking professional help included not being distressed by the symptoms, and thinking that the difficulty would clear up on its own. Multivariable regression analysis revealed that significant correlates of seeking professional help for women and men were level of distress about the sexual difficulty. With regard to women, those who were married, and/or from Portugal were more likely to have sought help. And regarding men, those who attended religious services were more likely to have sought professional help. These results have important implications for healthcare and can be used to inform the development and delivery of services for older adults who experience sexual difficulties.
Influence of Technological Parameters on the Isomerization of Geraniol Using Sepiolite
Authors: Fajdek-Bieda Anna , Wróblewska Agnieszka , Miądlicki Piotr , Szymańska Alicja , Dzięcioł Małgorzata , Booth Andy M. , Michalkiewicz Beata
Published: October 2019

In the current study, the isomerization of geraniol over a natural sepiolite as a catalyst was investigated and optimized. Prior to application in the isomerization process, the physical and chemical properties of sepiolite were characterized using a battery of instrumental techniques, including XRD, nitrogen adsorption at 77 K, SEM, EDXRF, UV–Vis and FT-IR. Results indicated that geraniol isomerization is very complicated due to the large number of reactions taking place. The catalytic studies showed that the main reaction products were β-pinene, ocimenes, linalool, nerol, citrals, thunbergol and isocembrol; all chemical products with commercial applications. The quantity of each of these products depended on the temperature, catalyst content and reaction time employed in the isomerization process. During the current study, these parameters were varied in a step-wise approach over the ranges 80–150 °C (temperature), 5–15 wt% catalyst content and reaction time of 15–1440 min. As linalool is one of the most commercially important reaction products, the geraniol isomerization method was studied to identify conditions producing the highest selectivity for this compound. The most beneficial conditions for geraniol conversion and linalool formation were established as a temperature of 120 °C, catalyst content of 10 wt% and a reaction time of 3 h.

Graphic Abstract
Cultural models of and for urban sustainability: assessing beliefs about Green-Win
Authors: Thornton Thomas F. , Mangalagiu Diana , Ma Yuge , Lan Jing , Yazar Mahir , Saysel Ali Kerem , Chaar Abdel Maoula
Published: October 2019

Green-Win is the proposal where that government, society, and business can all reap benefits while at the same time playing a vital role in the transition to sustainable development and lower carbon futures. We argue that, while the Green-Win proposition is central to many state and expert models of sustainability transitions, as a construction, it belies more complex trade-offs and cognitive models of sustainability and societal transitions. Cultural models are cognitive representations shared by a community which provide bothmodels ofthe world, which aid in interpreting what is in the world, how it works, what is possible (or not) and why, andmodels forthe world, which suggest how to act in it to bring about desired outcomes (cf. Geertz 1973). We surveyed 225 respondents in Shanghai, China, Istanbul, Turkey, and Beirut, Lebanon to assess their basic beliefs about sustainability, specifically whether it is possible to implement concrete practices that realize environmental sustainability goals in conjunction with economic development—the Green-Win proposition. We found important similarities and differences among urban stakeholders’ cultural models of sustainable development. For example, Chinese and Lebanese respondents displayed a strong belief that economic growth and environmental sustainability are compatible, while Turkish respondents showed significant disagreement with this proposition. We argue that such basic notions about the possibility of Green-Win opportunities between environmental sustainability and economic development are important to understand in the context of mitigating and adapting to climate change in critical urban environments. Cultural modelsofandforgreen development may either enable or inhibit transformations in urban systems according to local conditions. Finally, we discuss the potential implications of cultural models’ research for targeting communications and engendering collaborations among diverse stakeholders in order to align perspectives and overcome barriers that may otherwise limit successful visioning, planning, and implementation for transformation towards sustainable development.
Multiscale stochastic optimization: modeling aspects and scenario generation
Authors: Glanzer Martin , Pflug Georg Ch.
Published: October 2019

Real-world multistage stochastic optimization problems are often characterized by the fact that the decision maker may take actions only at specific points in time, even if relevant data can be observed much more frequently. In such a case there are not only multiple decision stages present but also several observation periods between consecutive decisions, where profits/costs occur contingent on the stochastic evolution of some uncertainty factors. We refer to such multistage decision problems with encapsulated multiperiod random costs, as multiscale stochastic optimization problems. In this article, we present a tailor-made modeling framework for such problems, which allows for a computational solution. We first establish new results related to the generation of scenario lattices and then incorporate the multiscale feature by leveraging the theory of stochastic bridge processes. All necessary ingredients to our proposed modeling framework are elaborated explicitly for various popular examples, including both diffusion and jump models.
Optimum processing parameters for coating polyester with silica nanoparticles using gravity sedimentation
Authors: Lu Zihan , Owens Huw
Published: October 2019

Gao et al. have proposed a facile method of silica nanoparticle synthesis called the solvent varying technique (SVT). Silica nanoparticles (SNPs) have been synthesized using the SVT. The diameters of the SNPs produced by these recipes are sensitive to drying temperature especially when they are used to form photonic crystal films on the surface of textiles. The colour appearance of the coated fabrics can be affected by unused reactants from the colloidal suspensions. These form a thin layer on the surface of the SNPs, which can adversely affect the constructive interference of light from the photonic crystal. In this paper, the original SNP solutions have been processed using a centrifuge and solvent replacement technique in order to reduce this problem. A TEM was used to record the morphology of the surface of the original and centrifuged particles. The resultant images show that there were fewer impurities present on the surface of the centrifuged SNPs than that of the original SNPs. DLS was used to measure the diameters and dispersion of the original and the centrifuged particles. A spectrophotometer was used to measure the reflectance of the samples. The chromaticities of the coated fabrics using both the original and centrifuged SNPs dried at a range of temperatures (40 °C, 60 °C, 80 °C and 100 °C) have been compared. It was determined that the centrifuged SNPs could be dried at higher temperatures than previously reported with little effect on the colour appearance of the photonic crystals.
Fracking and infant mortality: fresh evidence from Oklahoma
Authors: Apergis Nicholas , Hayat Tasawar , Saeed Tareq
Published: October 2019

This paper explores the impact of shale gas and oil fracking wells on infants’ health at birth across Oklahoma counties. The empirical analysis makes use of the Dumitrescu-Hurlin causality test, as well as the (long-run) Pooled Mean Group method. The results clearly document that there is a unidirectional relationship between fracking activities and three alternative indexes of infants’ health at birth, as well as a significant impact of fracking on infants’ health indicators. In addition, the results illustrate the substantial role of fracking through the drinking water quality channel.
Pathologies of Between-Groups Principal Components Analysis in Geometric Morphometrics
Authors: Bookstein Fred L.
Published: October 2019

Good empirical applications of geometric morphometrics (GMM) typically involve several times more variables than specimens, a situation the statistician refers to as “highp/n,” wherepis the count of variables andnthe count of specimens. This note calls your attention to two predictable catastrophic failures of one particular multivariate statistical technique, between-groups principal components analysis (bgPCA), in this high-p/nsetting. The more obvious pathology is this: when applied to the patternless (null) model ofpidentically distributed Gaussians over groups of the same size, both bgPCA and its algebraic equivalent, partial least squares (PLS) analysis against group, necessarily generate the appearance of huge equilateral group separations that are fictitious (absent from the statistical model). When specimen counts by group vary greatly or when any group includes fewer than about ten specimens, an even worse failure of the technique obtains: the smaller the group, the more likely a bgPCA is to fictitiously identify that group as the end-member of one of its derived axes. For these two reasons, when used in GMM and other high-p/nsettings the bgPCA method very often leads to invalid or insecure biological inferences. This paper demonstrates and quantifies these and other pathological outcomes both for patternless models and for models with one or two valid factors, then offers suggestions for how GMM practitioners should protect themselves against the consequences for inference of these lamentably predictable misrepresentations. The bgPCA method should never be used unskeptically—it is always untrustworthy, never authoritative—and whenever it appears in partial support of any biological inference it must be accompanied by a wide range of diagnostic plots and other challenges, many of which are presented here for the first time.
The future of in-store technology
Authors: Grewal Dhruv , Noble Stephanie M. , Roggeveen Anne L. , Nordfalt Jens
Published: October 2019

This paper introduces a conceptual framework for understanding new and futuristic in-store technology infusions. First, we develop a 2 × 2 typology of different innovative and futuristic technologies focusing on their level of convenience and social presence for the consumer. Next, we offer a series of propositions based on the idea that convenience and social presence can trigger vividness by enhancing consumer involvement, imagery, and elaboration, which ultimately leads to enhanced sales. Finally, the paper then focuses on four moderating areas—consumer traits, product/service dimensions, mental models and social networks—to understand how they might impact the vividness experienced via the technology.
Effects of direct stray current on the performance of cathodic disbonding epoxy powder coatings
Authors: Cui Yan-Yu , Bu Rui-Tao , Wang De-You , Wang Yu-Jun
Published: October 2019

The influence of the direction and magnitude of direct (DC) stray current on the disbonding performance of epoxy powder coating was studied by using electrochemical impedance spectroscopy and scanning electron microscopy technology. The results show that the application of DC stray current could accelerate the anodic dissolution. The peeling degree of the coating increases as the magnitude of positive DC stray current interference increases in the range of 2–8 V. With 16 V positive stray current disturbance, the degree of coating disbonding decreases. With the application of negative stray current, the coating peeling becomes more serious, and the degree of peeling increases as the DC stray current increases.
Acute tubulointerstitial nephritis and IgM deposits on glomerular capillary walls after immunotherapy with nivolumab for metastatic renal cell carcinoma
Authors: Irifuku Taisuke , Satoh Ayaka , Tani Hiroki , Mandai Kouichi , Masaki Takao
Published: October 2019

Nivolumab is an anti-programmed cell death-1 antibody that is utilized as an immune checkpoint inhibitor for several malignancies. However, this agent is associated with immune-related adverse events (irAEs), mainly in the spectrum of autoimmune disease including interstitial pneumonia, colitis, type 1 diabetes, and renal impairment. We herein present the case of a 59-year-old man with renal cell carcinoma who developed worsening renal function approximately 4 months after initiation of nivolumab. Urinalysis showed proteinuria and microscopic hematuria along with increase levels of N-acetyl-β-d-glucosaminidase. Renal biopsy revealed acute tubulointerstitial nephritis and thickening of the glomerular basement membranes. Immunofluorescence showed granular IgM deposits in capillary loops. We initiated high-dose prednisolone therapy with nivolumab, which improved renal function and achieved complete remission of proteinuria. Although renal irAEs are considered to be rare and glomerulonephropathy is not typical presentation, physicians need the close monitoring of renal function and urinalysis in patients under immunotherapy with this agents. In addition, our case provides a possible link between nivolumab and immune-mediated glomerulonephropathy.
Two-Stage Stochastic Variational Inequalities: Theory, Algorithms and Applications
Authors: Sun Hai-Lin , Chen Xiao-Jun
Published: October 2019

The stochastic variational inequality (SVI) provides a unified form of optimality conditions of stochastic optimization and stochastic games which have wide applications in science, engineering, economics and finance. In the recent two decades, one-stage SVI has been studied extensively and widely used in modeling equilibrium problems under uncertainty. Moreover, the recently proposed two-stage SVI and multistage SVI can be applied to the case when the decision makers want to make decisions at different stages in a stochastic environment. The two-stage SVI is a foundation of multistage SVI, which is to find a pair of “here-and-now” solution and “wait-and-see” solution. This paper provides a survey of recent developments in analysis, algorithms and applications of the two-stage SVI.
Crack
Authors: Farber David
Published: October 2019

A shattering account of the crack cocaine years from award-winning American historian David Farber, Crack tells the story of the young men who bet their lives on the rewards of selling 'rock' cocaine, the people who gave themselves over to the crack pipe, and the often-merciless authorities who incarcerated legions of African Americans caught in the crack cocaine underworld. Based on interviews, archival research, judicial records, underground videos, and prison memoirs, Crack explains why, in a de-industrializing America in which market forces ruled and entrepreneurial risk-taking was celebrated, the crack industry was a lucrative enterprise for the 'Horatio Alger boys' of their place and time. These young, predominately African American entrepreneurs were profit-sharing partners in a deviant, criminal form of economic globalization. Hip Hop artists often celebrated their exploits but overwhelmingly, Americans - across racial lines -did not. Crack takes a hard look at the dark side of late twentieth-century capitalism.
Facilitating collaborative animal research: The development and implementation of a Master Reciprocal Institutional Agreement for Animal Care and Use
Authors: Holthaus Kathryn , Goldberg David , Connelly Carolyn , Corning Brian , Nascimento Christina , Witte Elizabeth , Bierer Barbara E.
Published: October 2019

Ensuring appropriate review, approval, and oversight of research involving animals becomes increasingly complex when researchers collaborate across multiple sites. In these situations, it is important that the division of responsibilities is clear and that all involved parties share a common understanding. The National Institutes of Health Office of Laboratory Animal Welfare and the United States Department of Agriculture Animal Plant Health Inspection Service require an Institutional Animal Care and Use Committee (IACUC) to review the care and use of animals in research, and both agree that it is acceptable for one IACUC to review the work taking place at multiple institutions. With this in mind, several Harvard-affiliated hospitals and academic centers developed the Master Reciprocal Institutional Agreement for Animal Care and Use (Master IACUC Agreement) to support collaboration, decrease administrative burden, increase efficiencies, reduce duplicative efforts, and ensure appropriate protections for animals used in research. Locally, the Master IACUC Agreement has fostered greater collaboration and exchange while ensuring appropriate review and oversight of research involving animals. As multisite animal protocols become more prevalent, this Agreement could provide a model for a distributed, national network of IACUC reliance.
Numerical study of a turbulent separation bubble with sweep
Authors: Coleman G. N. , Rumsey C. L. , Spalart P. R.
Published: October 2019

Direct numerical simulation (DNS) is used to study a separated and rapidly reattached turbulent boundary layer over an idealized $35^{\circ }$ infinite swept wing. The separation and reattachment are induced by a transpiration profile at fixed distance above the layer, with the pressure gradient applied to a well-defined, fully developed, zero-pressure-gradient (ZPG) collateral state. To isolate the influence of the sweep, results are compared with one of our earlier DNS of an unswept flow, with the same chordwise transpiration distribution and appropriate upstream momentum thickness. The independence principle (IP) traditionally proposed for swept wings, which is exact for laminar flows, is found to be close to valid in some regions (bridging the separation/reattachment zone) and to fail in others (in the ZPG layers upstream and downstream of the separation). This is assessed primarily through the skin friction and integral thicknesses. The regions in which the IP is approximately valid correspond to regions of diminished Reynolds-stress divergence, compared to the pressure-gradient magnitude. The mean-velocity profiles exhibit significant skewing as the flow develops, while the velocity magnitude departs only slightly from the ZPG logarithmic profile, even above the separation zone. Implications for Reynolds-averaged turbulence modelling are discussed.
Let’s Talk: What FinReg Can Learn from New Governance (and Vice Versa)
Authors: Krawiec Kimberly D.
Published: October 2019

Lauren Edelman’sWorking Law: Courts, Corporation, and Symbolic Civil Rights(2016) is remarkably relevant to the study of financial regulation. In particular, three factors that Edelman identifies as contributing to legal endogeneity and symbolic compliance—ambiguous law, a lack of clear outcome measures, and the presence of legal intermediaries—are especially salient in this context. It has long been recognized that powerful financial institutions and the lawyers, lobbyists, and other agents who serve them have the ability to influence the law ex ante, through political lobbying. Edelman’s work reinforces the point that they may also do so ex post through an endogenous process of interpretation, implementation, and, ultimately, enshrinement of symbolic compliance with ambiguous law.
Status report of the Trondheim Radiocarbon Laboratory
Authors: Seiler Martin , Grootes Pieter M , Haarsaker John , Lélu Sylvie , Rzadeczka-Juga Izabela , Stene Sølvi , Svarva Helene , Thun Terje , Værnes Einar , Nadeau Marie-Josée
Published: October 2019

The Trondheim radiocarbon (14C) laboratory has evolved from a traditional radiocarbon decay counting laboratory to an accelerator mass spectrometry (AMS) facility primarily measuring 14C. This evolution required adjustments in sample preparation and data handling to match the capacity of the AMS system and reduction in sample sizes to about 1 mgC. We summarize here the steps involved in dating a sample at the National Laboratory for Age Determination in Trondheim, Norway. These include the structure of our sample database for information handling, sample cleaning procedures for different sample types, our reduction systems, both an automated EA-based system for regular use and a manual system for more challenging samples, and data evaluation. We will also briefly summarize the capabilities of our isotope-ratio mass spectrometer.
Tremoring transits: railways, the Royal Observatory and the capitalist challenge to Victorian astronomical science
Authors: GILLIN EDWARD J.
Published: October 2019

Britain's nineteenth-century railway companies traditionally play a central role in histories of the spread of standard Greenwich time. This relationship at once seems to embody a productive relationship between science and capitalism, with regulated time essential to the formation of a disciplined industrial economy. In this narrative, it is not the state, but capitalistic private commerce which fashioned a national time system. However, as this article demonstrates, the collaboration between railway companies and the Royal Greenwich Observatory was far from harmonious. While railways did employ the accurate time the observatory provided, they were also more than happy to compromise the astronomical institution's ability to take the accurate celestial observations that such time depended on. Observing astronomical transits required the use of troughs of mercury to reflect images of stars, but the construction of a railway too near to the observatory threatened to cause vibrations which would make such readings impossible. Through debates over proposed railway lines near the observatory, it becomes clear how important government protection from private interests was to preserving astronomical standards. This article revises our understanding of the role of railway companies in the dissemination of standard time and argues that state intervention was essential to preserving Victorian British astronomical science.
IgY antibody and human neurocysticercosis: a novel approach on immunodiagnosis usingTaenia crassicepshydrophobic antigens
Authors: Carrara Guilherme M. P. , Silva Gabriela B. , Faria Lucas S. , Nunes Daniela S. , Ribeiro Vanessa S. , Lopes Camila A. , Gonçalves-Pires Maria do Rosário F. , Santos Malu M. , Borges Isabela P. , Ferreira-Junior Álvaro , Ávila Veridiana M. R. , Costa-Cruz Julia M.
Published: October 2019

Human neurocysticercosis (NCC) is a worldwide neglected disease caused byTaenia soliummetacestode and responsible for various complications and neurological disorders. This study aimed to evaluate the use of specific immunoglobulin Y (IgY) produced by laying hens immunized with a hydrophobic fraction ofTaenia crassicepsmetacestodes (hFTc) in NCC diagnosis. Egg yolk IgY antibodies were fractionated, purified and characterized. Enzyme-linked immunosorbent assay (ELISA) was carried out to evaluate the production kinetics and avidity maturation of anti-hFTcIgY antibodies throughout the IgY obtention process. Antigen recognition tests were carried out by Western blotting and immunofluorescence antibody test using purified and specific anti-hFTcIgY antibodies for detection of parasitic antigens ofT. crassicepsandT. soliummetacestodes. Sandwich ELISA was performed to detect circulating immune complexes formed by IgG and parasitic antigens in human sera. The results showed high diagnostic values (93.2% sensitivity and 94.3% specificity) for immune complexes detection in human sera with confirmed NCC. In conclusion, specific IgY antibodies produced from immunized hens with hFTcantigens were efficient to detectT. soliumimmune complexes in human sera, being an innovative and potential tool for NCC immunodiagnosis.
The Illustrated Dioskourides Codices and the Transmission of Images during Antiquity
Authors: Thomas Joshua J.
Published: October 2019

A parchment codex of the early sixth centurya.d., now in Vienna, contains a remarkable series of nearly 400 full-page illustrations of individual botanical species. These illustrations accompany an alphabetical recension of a pharmacological treatise on the medicinal properties of plants written by Dioskourides of Anazarbos, a Greek author of the first centurya.d. Both the date of the codex and the style of its botanical illustrations have encouraged suggestions that the latter were modelled somehow on classical archetypes. This article presents new observations in support of the classical archetypes theory, but questions the traditional view that these archetypes were transmitted by ‘illustrated texts’ or ‘pattern books’ executed in papyrus or parchment. What follows is a new hypothesis concerning the nature of the artistic intermediaries used by painters, mosaicists and sculptors during antiquity.
Inequalities in older LGBT people's health and care needs in the United Kingdom: a systematic scoping review
Authors: Kneale Dylan , Henley Josie , Thomas James , French Robert
Published: October 2019

The hostile environment that older lesbian, gay, bisexual and transgender (LGBT) people faced at younger ages in the United Kingdom (UK) may have a lasting negative impact on their health. This systematic scoping review adds to the current knowledge base through comprehensively synthesising evidence on what is known about the extent and nature of health and care inequalities, as well as highlighting gaps in the evidence which point the way towards future research priorities. We searched four databases, undertook manual searching, and included studies which presented empirical findings on LGBT people aged 50+ in the UK and their physical and mental health or social care status. From a total of 5,738 records, 48 papers from 42 studies were eligible and included for data extraction. The synthesis finds that inequities exist across physical and mental health, as well as in social care, exposure to violence and loneliness. Social care environments appeared as a focal point for inequities and formal care environments severely compromised the identity and relationships that older LGBT people developed over their lifecourse. Conversely, the literature demonstrated how some older LGBT people successfully negotiated age-related transitions,e.g.emphasising the important role of LGBT-focused social groups in offsetting social isolation and loneliness. While there exist clear policy implications around the requirement for formal care environments to change to accommodate an increasingly diverse older population, there is also a need to explore how to support older LGBT people to maintain their independence for longer, reducing the need for formal care.
KVLTER than KVLT: ‘True (Norwegian) black metal’ and the satanic politics of Bataillean ‘authenticity’
Authors: Bujalka Eva
Published: October 2019

Although there has recently been significant work published on the relationship between twentieth-century French (anti-)philosopher Georges Bataille's theories of religion and violence, and the sound and politics of black metal, little has been done to address Bataille's and black metal's shared concern with the problem of ‘authenticity’. Their concern, determined by their complicity with ‘evil’, is centred on a critique of modernity. I will read, with a specific focus on the second wave of Norwegian black metal, black metal's connivance with evil through Bataille's notion of authentic literature. Although two very different mediums – literature and music – Bataille's concept is applicable to a reading of black metal because of his invocation of evil and the Luciferian in his interpretation of authenticity. Bataille argues that authentic literature is necessarily diabolical because of the Nietzschean form of sovereignty that the author momentarily attains at the conception of the modern world – that is, in the wake of the death of God. The authenticity that Bataille and black metal seek is therefore bound up both with godlessnessandthe satanic.
Cues for word-learning during shared book-reading and guided play in preschool
Authors: HADLEY Elizabeth Burke , DICKINSON David K.
Published: October 2019

The present study examines the perceptual, linguistic, and social cues that were associated with preschoolers’ (4;11) growth in word-learning during shared book-reading and guided play activities. Small groups of three preschoolers (n= 30) and one adult were video-recorded during an intervention study in which new vocabulary words were explicitly taught. Adult use of taught words was coded for perceptual and linguistic cues and type of social interaction. Hearing taught words used in the book text and learning information about words’ meanings during play was positively associated with growth in word-learning. Adult use of words in responsive, or child-initiated, interactions was positively associated with word-learning growth in both book-reading and play, while adult-initiated use of words was negatively associated with word-learning growth in both settings.
Enhanced function-means modeling supporting design space exploration
Authors: Müller Jakob R. , Isaksson Ola , Landahl Jonas , Raja Visakha , Panarotto Massimo , Levandowski Christoffer , Raudberget Dag
Published: October 2019

One problem in incremental product development is that geometric models are limited in their ability to explore radical alternative design variants. In this publication, a function modeling approach is suggested to increase the amount and variety of explored alternatives, since function models (FM) provide greater model flexibility. An enhanced function-means (EF-M) model capable of representing the constraints of the design space as well as alternative designs is created through a reverse engineering process. This model is then used as a basis for the development of a new product variant. This work describes the EF-M model's capabilities for representing the design space and integrating novel solutions into the existing product structure and explains how these capabilities support the exploration of alternative design variants. First-order analyses are executed, and the EF-M model is used to capture and represent already existing design information for further analyses. Based on these findings, a design space exploration approach is developed. It positions the FM as a connection between legacy and novel designs and, through this, allows for the exploration of more diverse product concepts. This approach is based on three steps – decomposition, design, and embodiment – and builds on the capabilities of EF-M to model alternative solutions for different requirements. While the embodiment step of creating the novel product's geometry is still a topic for future research, the design space exploration concept can be used to enable wider, more methodological, and potentially automated design space exploration.
Mortuary Pottery and Sacred Landscapes in Complex Hunter-gatherers in the Paraná Basin, South America
Authors: Loponte Daniel , Ottalagano Flavia , Pérez Maricel , Malec Laura , Ramos Cinthia , Bozzano Patricia , Iribarren Manuel , Pérez Rodolfo , Leiva Graciela , Domínguez Silvia , Alí Sheila , Acosta Alejandro
Published: October 2019

Tubular pottery comprises certain peculiar artifacts that were produced by late Holocene complex hunter-gatherer societies in southeastern South America for unknown purposes. Some authors have related them to mortuary behaviour which has also been suggested by historical sources, while others have considered domestic use. In this paper, the technical, compositional and functional properties of these artifacts are explored in order to contrast both hypotheses, given an example of how technical analysis allows the identification of special pottery within archeological contexts. This analysis includes a study of the fabrics involved using low and high magnification, thin sections, Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy, Mössbauer Spectroscopy, Laser Induced Breakdown Spectroscopy and fatty acid profiles. The results show that these tubular artifacts are not fit structurally for utilitarian purposes and show no evidence of domestic use. Based on these results and on historical data, it can be postulated that they were used as part of mortuary rituals, thus becoming part of the select global group of pottery manufactured exclusively for mortuary purposes.
Utica’s urban centre from Augustus to the Antonines
Authors: Ben Jerbania Imed , Dufton J. Andrew , Fentress Elizabeth , Russell Ben
Published: October 2019

Since 2010, a team from the Tunisian Institut National du Patrimoine and the University of Oxford1 has been investigating Utica’s monumental centre, located at the tip of the promontory on which the city is built (fig. 1). The range and scale of architectural elements littering this area were remarked upon by most antiquarian investigators of the site. Nathan Davis, working at the site in 1858, noted that, despite the fact that it “had been ransacked for building materials”, this part of the city was covered with “marble and granite shafts, capitals, and cornices, of every order, size, and dimension”.2 Alfred Daux even observed that local residents referred to the largest building of the zone as the “Dar Es Sultan” (Palace of the Sultan), such was its magnificence.3 Aerial photographs commissioned by A. Lézine in the 1950s (fig. 2) show the area at the head of the promontory almost completely robbed out during and immediately after the Second World War, giving it a rather desolate aspect.
Towards a cultural biography of Roman painting
Authors: Bragantini Irene
Published: October 2019

Using a term drawn from economic anthropology1 and pushing the boundaries of this type of analysis, I would like to describe an attempt to trace in time and space the roots of the technical, stylistic and iconographic know-how that gave form to Roman painting. Considering the fragmentary nature of the evidence at our disposal, the argumentation set forth here cannot follow a linear path containing various steps that can all be neatly demonstrated. I believe that the time is right, however, to tackle Roman painting — and particularly painting in the domestic setting — with more conviction. Although understanding the rôle and nature of the patrons and painters remains an objective that is still far off, it is probably worth investigating the traditions that enjoyed some level of continuity in Roman painting and the concrete ways and contexts in which the process unfolded. The aim is to achieve a deeper understanding of the rôle that this artistic technique played in a society that made ample use of it during a fundamental phase of its history. In the 1st c. B.C. and 1st c. A.D., in the brief period that saw the transition from Republic to Empire, the domestic ideology of Roman society found expression in a decorative system marked by a continuous stream of innovations with respect to themes, schemes and ornament that were adopted consistently by a broad spectrum of patrons. Indeed, beyond simply protecting and covering the walls of dwellings, figurative painting — especially of such a complex nature as we are dealing with here — added a wide range of elements which I believe it is useful to investigate.