bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum levels of tumour necrosis factor (TNF-α) and interleukin-17 (IL-17) in patients with nail psoriasis: A cross-sectional study
Authors: Bhoi Anil Kumar , Grover Chander , Singal Archana , Kashyap Bineeta , Dibyashree Dibyashree
Published: May 2024

Background

Psoriasis is a common chronic inflammatory disorder affecting all aspects of a patient’s life. Nail involvement is frequent, but little is known about its associated inflammatory biomarker profile, including similarities or differences from cutaneous disease.

Aims

We conducted this cross-sectional study to evaluate serum levels of inflammatory cytokines [tumour necrosis factor-alpha (TNF-α) and interleukin -17 (IL-17)] in patients with nail psoriasis and compared these to psoriasis patients without nail involvement, as well as in non-psoriatic healthy controls.

Methods

Adult psoriasis patients with (Group I, n = 30) and without nail involvement (Group-II, n = 30) were sequentially recruited. In addition, non-psoriatic healthy controls (Group-III, n = 20) were recruited. The nail disease severity by NAPSI score was determined for patients in Group I. Cutaneous disease severity (by PASI score) and presence of psoriatic arthritis (through CASPAR criteria) were evaluated for patients in Groups I and II. Serum levels of TNF-α, IL-17, erythrocyte sedimentation rate (ESR), rheumatoid factor (RA factor), and anti-cyclic citrullinated peptide antibody (Anti-CCP) were evaluated for all three groups.

Results

The median age was significantly higher for Group I as compared to Group II patients (41 ± 12.6 years vs 30 ± 12.4 years, p = 0.017). Group I patients also had higher median PASI score than Group II patients, although the difference was not statistically significant (10 ± 11.41 vs 6.50 ± 5.46, p = 0.275). The mean serum IL-17 levels were significantly higher for Group-I (113.39 ± 251.30 pg/mL) than Group II (27.91 ± 18.22 pg/mL, p = 0.002) and Group III (25.67 ± 12.08 pg/mL, p = 0.005). A weak positive correlation was found between NAPSI and serum IL-17 levels (Spearman’s Rho = 0.355) though not statistically significant (p = 0.054). Correlation between serum IL-17 and PASI was poor for Group-I patients (Spearman’s Rho = 0.13, p = 0.944) and strongly negative for Group-II patients (Spearman’s Rho = −0.368, statistically significant with p = 0.045). The mean serum levels of TNF-α were below the detection threshold of the assay kit, hence no meaningful comparison could be made.

Limitations

A small sample size and low sensitivity of TNF-α assay kit.

Conclusion

Our study showed that nail psoriasis could be independently associated with an elevation of IL-17. This can help choose appropriate drugs and estimate drug response in patients with nail psoriasis.
Identification and benchmarking of Myokinasib-II as a highly selective and potent chemical probe for exploring MLCK1 inhibition
Authors: Kumar Gautam , Agarwala Prema Kumari , Srivatsav Aswin T. , Ravula Ashok , Ashmitha G. , Balakrishnan Sreenath , Kapoor Shobhna , Narayan Rishikesh
Published: May 2024

Deciphering functional relevance of every protein is crucial to developing a better (patho)physiological understanding of human biology. Discovery and use of quality chemical probes propel exciting developments for developing drugs in therapeutic areas with unmet clinical needs. Myosin Light Chain Kinase (MLCK) serves as a possible therapeutic target in a plethora of diseases, including inflammatory diseases, cancer etc. Recent years have seen substantial increase in interest in exploring MLCK biology. However, there is only one widely used MLCK modulator, namely ML-7, that too with a narrow working concentration window and high toxicity profile leading to limited insights. Herein, we report the identification of a potent and highly selective chemical probe, Myokinasib-II, from the synthesis and structure-activity relationship studies of a focussed indotropane-based compound collection. Notably, it is structurally distinct from ML-7 and hence, meets the need for an alternative inhibitor to study MLCK biology as per the recommended best practices. Moreover, our extensive benchmarking studies demonstrate that Myokinasib-II displays better potency, better selectivity profile and no non-specific interference in relevant assays as compared to other known MLCK inhibitors.
Size Onset of Metallic Behavior in Neutral Aluminum Clusters
Authors: Rottener Chase , Jarman Carter , Sutton Shaun , Sayres Scott
Published: May 2024

The excited state lifetimes of neutral (Al)n clusters up to ~1 nm in diameter in size, where n ≤ 43, are systematically measured with femtosecond time-resolved mass spectrometry. The onset of metallic behavior is identified as a distinct change in the relaxation behavior initiated with single ultraviolet (400 nm) photon excitation. The experimentally measured excited state lifetimes gradually decrease with size for small molecular scale clusters (n < 10) before becoming indistinguishable for larger clusters (n > 9), where the measurements are comparable to electron-lattice relaxation time of bulk Al (~300 fs). Particularly intense, or magic, Aln clusters do not exhibit any significant excited state lifetime behavior. Time-dependent density functional theory quantify the excited state properties and are presented to show that dynamics are strongly tied to the excited state charge carrier distributions and overlap, rather than detailed changes related to changes in the cluster’s electronic and geometric structure. The consistency in excited state lifetimes for clusters larger than n = 9 is attributed to the hybridization of the s- and p- orbitals as well as increasing delocalization. Al3 exhibits unique temporal delay in its transient behavior that is attributed to a transition from triangular ground state to linear structure upon excitation.
Energy transfer-induced polymerization of acrylates
Authors: Liu Jian , Wei Yaxiong , Ma Liangwei , Sun Siyu , Xu Xinsheng , Tian He , Ma Xiang
Published: May 2024

Photopolymerization of acrylate monomers has been the focus of research for quite a long time, but most of the researches concentrated on using exogenous radical species as means to achieve photo-induced polymerization. Herein, we exploit the energy transfer process between the luminescent molecule and the acrylate monomer to accomplish a two-component photoinduced polymerization reaction, and explored the universality of this strategy. Via the choice of thiochromanone as a template for the study, the photochemistry processes involved were explored in depth. The effect of radical polymerization processes was also excluded by time-resolved electron paramagnetic spectrum. As a result, it provides inspiration for further discussions on the roles played by monomers in photo-induced polymerization.
An Open-Shell IrII/IrIV Redox Couple Outperforms the Conventional IrI/IrIII Pair for the Catalytic Isomerization of Olefins
Authors: Pita-Milleiro Alejandra , Hidalgo Nereida , Moreno Juan J. , Fernandez Israel , Campos Jesus
Published: May 2024

The chemistry of mononuclear open-shell complexes of precious transition metals is largely underdeveloped, which contrasts with that of first-row transition metals and their catalytic applications. This is particularly true for IrII complexes and its almost inexistent participation in catalysis. Here we report the synthesis and characterization of a small family of mononuclear IrII metalloradicals constructed around a POCOP pincer ligand (POCOP = C6H3-2,6-(OP(tBu)2)2) and explore their performance as catalysts for olefin isomerization, a fundamental process for alkane metathesis. These paramagnetic species are up to 20 times more active than their diamagnetic IrI analogues. Strikingly, the elementary steps involved in the catalytic action of both IrI and IrII are virtually identical according to our computational investigations. However, the proposed unprecedented IrII/IrIV redox cycle presents faster kinetics than the traditional IrI/IrIII route due to much lower barriers for the key oxidative addition and reductive elimination events, a feature that we rationalize by means of the Activation Strain Model-Energy Decomposition Analysis-approach. In essence, we report the first example of a catalytic system based on a mononuclear IrII/IrIV redox couple, a fundamental contribution to the underexplored chemistry of IrII compounds that stresses the necessity to broaden the catalyst search and design guidelines beyond conventional redox cycles, including those based on platinum-group metals.
Teatro e música para todos - o Laboratório de Dramaturgia da Universidade de Brasília (1998-2021)
Authors: Mota Marcus
Published: May 2024

Este livro apresenta o pioneiro esforço do Laboratório de Dramaturgia da Universidade de Brasília (Ladi-UnB) em correlacionar pesquisa universitária e produção artística em alto nível, tendo produzido, além de processos criativos que reinterpretam obras do repertório operístico e textos literários clássicos, publicações em anais de eventos e revistas nacionais e internacionais. A isto adicione-se a orientação de dezenas de teses e dissertações, e realização de diversos projetos financiados pelo CNPq. O esforço de redigir este livro objetivou integrar o campo das Artes na celebração e mesmo memória de nossa Universidade: na fundação da Universidade de Brasília, no rol de seus objetivos essenciais, lá estava: “congregar mestres, cientistas, técnicos e artistas e lhes assegurar os necessários meios materiais e as indispensáveis condições de autonomia e de liberdade para se devotarem à ampliação do conhecimento, ao cultivo das artes e a sua aplicação a serviço do homem”. O know-how em dramaturgia musical do Ladi-UnB é o foco desta obra: trazer para o público espetáculos dramático-musicais elaborados e realizados no consórcio entre professores, alunos do Instituto de Artes da UnB, artistas da cidade, e que foram apresentados na comunidade do Distrito Federal. Teatro e Música para todos!
Public Communication Strategy in Increasing Community Involvement in Central Java
Authors: Putra Muhammad Amril Pratama , Rusdi Muhammad
Published: May 2024

The role of public communication is of utmost significance in changing the dynamics of society, encompassing social, political, and economic aspects. This research analyzes the public communication strategy through social media, particularly Twitter, conducted by Ganjar Pranowo, the Governor of Central Java. The research method used in this study is content analysis with social media.  Hashtags, as a key element in the communication strategy, play an important role in building a positive image of Central Java. Hashtag analysis reveals Ganjar Pranowo's focus on promoting comfort, infrastructure and handling COVID-19 in his region. Interaction patterns with official government and media accounts show strong collaboration in disseminating transparent information and increasing public engagement. Governor Ganjar Pranowo's active engagement on social media reflects an effective strategy to build trust and increase public engagement in modern governance. The results of this study provide insights into the potential and role of social media in strengthening public communication in the realm of government.
Political Relations: Political Identity and Social Media in Elections in Indonesia
Authors: Candra Ade , Fauzi Anwar , Rahmadhani Marissa Laila
Published: May 2024

This research examines the role of social media in shaping political identity and political participation in contemporary Indonesia. Utilizing document analysis, the study explores how individuals and societal groups use social media as a tool to influence and participate in political discourse. The method employed in this research is qualitative descriptive. The findings reveal that social media facilitates a framework for personal action, enabling widespread participation in various political and social issues, and integrating personal lifestyle values into political dialogue. The study also pays attention to the challenges faced by political parties in Indonesia in attracting voters, especially the younger generation who are highly engaged with social media, in the lead-up to the 2024 simultaneous elections. Lastly, it is found that social media has deepened social interaction and information for the millennial generation, particularly during the Covid-19 pandemic, affecting their views on politics and religion. The conclusion of this research emphasizes the importance of social media in shaping the political landscape in Indonesia, providing significant insights into how digital technology affects political participation and social identity.
Educational Policy Dilemma: New Student Admissions Policy Based on The Zoning System
Authors: Mustari Nuryanti
Published: May 2024

The purpose of this study is to determine the implementation of a new student admission policy based on the zoning system. This study was conducted in East Luwu Regency, South Sulawesi, Indonesia because the implementation of a new student admission policy based on the zoning system caused several problems, such as ineffective socialization. This was carried out by the East Luwu Region Provincial Education Office Branch to the community which caused the parents or guardians and students not to understand the technical instructions for registration. Furthermore, this study used a descriptive qualitative method and data obtained are analyzed using the help of Nvivo12 Plus software. The result showed that policies are implemented based on the indicators of inter-organizational relationship behavior. This makes the East Luwu Region XII Provincial Education Office Branch and Senior High Schools to maintain mutual relationship with each other. Furthermore, it helps them to carries out organizational control and they are even professionals in completing their tasks. Meanwhile, based on these indicators, there have been many positive responses from the target group community but still, have a negative one. This is because of less optimal things from the implementation of new student admission policy based on the zoning system.
Successes and failures of conflict governance: Lessons from Aceh, Indonesia and Moro, Philippines
Authors: Badu Muhammad Nasir , Syafhendry Syafhendry , Tenorio Christine B.
Published: May 2024

The purpose of this study is to analyze ethnic conflict management in Aceh (Indonesia) and Moro (Philippines) conflicts. The Aceh conflict was considered resolved after the signing of the Helsinki agreement, which was mediated by the Crisis Management Initiative (CMI), an international NGO based in Finland, on 15 August 2005 between Indonesian government and the Free Aceh Movement (Gerakan Aceh Merdeka, GAM). Meanwhile, the Moro (Philippines) conflict is still ongoing despite the TRIPOLI agreement signed and mediated by the OIC (Organization of Islamic Conference) between the Philippine government and the Moro National Liberation Front (MNLF) on 23 December 1976 and also with the MILF in 2001. This research method uses a qualitative approach. Primary data was obtained through interviews with figures who were considered competent in the Aceh conflict and the Moro conflict. The results of this study show that CMI in Aceh has succeeded in changing the situation of ethnic conflict into a situation that can reduce and reduce escalation and direct conflict actors towards conflict resolution. Peacemaking, peacekeeping and peace building have been played well by CMI involving the international community such as ASEAN and the European Union to manage the conflict. Meanwhile, in Moro the OIC failed to bring the conflict actors to solve their problems. The Philippine government lacks a robust vision, framework, and the necessary political will to effectively address the Moro conflict, which is of concern to the Organization of Islamic Cooperation (OIC).
Research on Sports Public Service Supply in the Chengdu–Chongqing Twin-City Economic Circle under the Background of Regional Economic Development
Authors: Yang Yiming , Liu Yun , Huang Yu
Published: May 2024

Using literature, questionnaires, interviews, and mathematical statistics to investigate the current situation of sports public services in the Chengdu–Chongqing Twin-city Economic Circle. The results show that there are some problems in Chengdu–Chongqing sports public services, such as big difference in the development level of supply between urban and rural areas, low supply level, low efficiency, supply mechanism defect, lack of social sports instructors, an outstanding contradiction between the quality of sports public service and residents’ demand. To address the problems, government departments should accelerate the transformation of government functions, improve the relevant regulations and systems, increase the investment in sports public services, improve the quality of supply, cultivate the backbone team, integrate resources, and combine the national characteristics with regional characteristics, take into account the personalized needs of the residents, combine the sports public services with intelligence, and build the service system of “Internet + Fitness.”
Research on the Impact of China’s Foreign Trade Technology Spillover on Green Total Factor Productivity of Countries Along the “Belt and Road”: Based on the Institutional Quality Threshold Effect
Authors: Chai Li , Ma Longnan , Meng Lingwei
Published: May 2024

China’s growing trade with countries along the “Belt and Road” Initiative is accompanied by a focus on green development. Based on the panel data from 2007 to 2018, this paper establishes a threshold regression model to empirically analyze the institutional quality threshold effect of China’s foreign trade technology spillover on the GTFP of countries along the “Belt and Road.” The results show that China’s foreign trade technology spillover has a significant institutional quality double threshold effect on the green total factor productivity of the countries along the “Belt and Road.” As the institutional quality of the countries along the “Belt and Road” crosses a specific threshold value, the impact of China’s foreign trade technology spillover on the green total factor productivity of the countries along the “Belt and Road” has a significant positive promoting effect, and corresponding suggestions are put forward.
Research on College Network Information Security Protection in the Digital Economy Era
Authors: Zhang Libin
Published: May 2024

In the era of the digital economy, the informatization degree of various industries is getting deeper and deeper, and network information security has also come into people’s eyes. Colleges and universities are in the position of training applied talents, because of the needs of teaching and education, as well as the requirements of teaching reform, the information construction of colleges and universities has been gradually improved, but the problem of network information security is also worth causing people to ponder. The low security of the network environment will cause college network information security leaks, and even hackers will attack the official website of the university and leak the personal information of teachers and students. To solve such problems, this paper studies the protection of college network information security against the background of the digital economy era. This paper first analyzes the significance of network information security protection, then points out the current and moral problems, and finally puts forward specific countermeasures, hoping to create a safe learning environment for teachers and students for reference.
SWOT Analysis and Recommendations for Enhancing Sino-Russian Agricultural Trade Cooperation
Authors: Fang Huilan
Published: May 2024

With the outbreak of the Russian–Ukraine conflict, the changes in agricultural trade between China and Russia are receiving more and more attention. This study analyzes the current status of Sino-Russian agricultural trade and employs a SWOT analysis to explore the strengths, weaknesses, opportunities, and threats within their agricultural trading activities. The findings suggest there are opportunities for further optimization and enhancement in the Sino-Russian agricultural trade. Based on this, suggestions proposed include accelerating the development of transportation hubs, facilitating agricultural trade, refining legal frameworks for agricultural exports, and expediting the establishment of economic cooperation zones.
Micro, Small, and Medium Enterprises’ Cross-Border Business Strategies
Authors: Chen Xuan , Xia Yijun , Hou Tian
Published: May 2024

This paper explores the operational strategies of cross-border micro, small, and medium enterprises (MSMEs). Against the backdrop of globalization and digitalization, cross-border trade has become one of the important pathways for many MSMEs to achieve growth and competitive advantage. Firstly, the paper outlines the concept and characteristics of cross-border MSMEs, as well as the analysis of their operational environment in the context of globalization, including political, economic, social, technological, environmental, and legal factors. Secondly, the paper proposes operational strategies for cross-border MSMEs, including international market selection and positioning, cross-border marketing strategies, supply chain management, cross-border financial management, and cross-border risk management. Finally, the paper summarizes the importance of effectively implementing these strategies for cross-border MSMEs to seize international market opportunities, reduce operational risks, and enhance competitiveness and profitability.
A FORMAÇÃO INICIAL E CONTINUADA DE PROFESSORES PARA O USO PEDAGÓGICO DE TECNOLOGIAS DIGITAIS NO ENSINO MÉDIO
Authors: Soares Marijane , Teixeira Porto Ana Paula
Published: May 2024

No momento em que a sociedade busca o enfretamento de desafios, como é o caso de qualificar os processos de ensino e aprendizagem no ambiente escolar, o uso das TDs ganha um novo capítulo no contexto das práticas pedagógicas, ao mesmo tempo em que a formação dos professores para esse fazer auxiliado pelos instrumentos tecnológicos. Assim, o objetivo do presente estudo foi levantar as características da formação inicial e formação continuada dos professores, no que se refere a capacitação desses profissionais para o uso das tecnologias digitais em suas práticas pedagógicas para o ensino médio. Para o alcance do objetivo traçado foi desenvolvida uma pesquisa descritiva, com caráter metodológico indutivo e análise qualitativa, com a coleta de dados primários em 8 (oito) escolas públicas de Rondonópolis-MT, tendo como público participante 74 (setenta e quatro) professores. A partir dos dados coletados conclui-se que a formação inicial dos professores ofereceu maior nível de conhecimento na elaboração e execução de práticas pedagógicas, no entanto, a formação tecnológica desses mesmos professores foi maior na formação continuada, o que evidencia os benefícios da busca por formação continuada para qualificar os professores gerando competências e habilidades para trabalhar com as TDs nas práticas pedagógicas.
O POTENCIAL FORMATIVO DA PESQUISA NARRATIVA NA FORMAÇÃO CONTINUADA DO DOCENTE UNIVERSITÁRIO
Authors: Souza Mauro José de , Monteiro Filomena Maria de Arruda , Flores José Ignacio Rivas
Published: May 2024

A reflexão sobre a experiência na formação continuada de docentes ingressantes na educação superior e a pesquisa narrativa constituem o foco prioritário de discussão desta investigação. Face a uma política educacional obscura e omissa, a educação superior sofre com o empresariamento que tem orientado os sistemas educacionais em escala mundial, o qual reverbera na institucionalização de programas formativos destinados aos docentes universitários. Considerando o cenário da institucionalização de ações formativas, questionamos qual o potencial formativo da investigação narrativa na formação continuada de docentes universitários? Desse modo, nosso objetivo foi refletir sobre o papel da pesquisa narrativa na formação continuada do docente universitário, analisando seu potencial formativo em acessar o conhecimento, necessidades e experiências dos docentes envolvidos. Tomando a pesquisa narrativa como fenômeno e método investigativo, aportamos narrativas de docentes universitários provenientes dos cenários brasileiro e espanhol, que evidenciaram, por meio da reflexão sobre suas experiências, a potencialidade da pesquisa narrativa na formação continuada de docentes universitários e nos permitiram concluir ser esta uma possibilidade formativa e emancipatória ímpar e necessária a orientar os programas formativos institucionalizados destinados ao docente universitário.
UMA VIAGEM ERRANTE: O DESVIO COMO MÉTODO EM PESQUISAS NARRATIVAS E (AUTO)BIOGRÁFICAS – CONTRIBUIÇÕES DE WALTER BENJAMIN
Authors: Petrucci dos Santos Rosa Camila , Carvalho Koyama Adriana , Ferreira de Souza Bragança Inês
Published: May 2024

O presente artigo convida à reflexão sobre o desvio como método em pesquisas narrativas e (auto)biográficas, a partir das contribuições de Walter Benjamin, por meio da socialização de lampejos de uma viagem errante, vivida em uma pesquisaformação que tematizou as infâncias, na relação com as memórias, as narrativas e os cotidianos escolares. Em um contexto em que a aceleração desenfreada faz com que as experiências sejam cada vez mais esfiapadas, soterradas e dadas como ruínas, o pensamento benjaminiano potencializa o inusitado dos cotidianos que se fazem presentes na vida, na formação, na pesquisa, na produção de conhecimentos em educação. O entrecruzamento dialógico de narrativas (auto)biográficas de múltiplas infâncias, escritas em mônadas, faz emergir potencialidades da racionalidade estética e das relações entre a memória e narração. O texto convida a um voltar-se para as nossas experiências vividas na pesquisa, sempre de novo, com uma alteridade renovada, assim como as crianças fazem cotidianamente em suas relações, em movimentos que subvertem caminhos antes fixados. Ao mesmo tempo que o desvio como método pode parecer um risco, ao nos perdermos, podemos produzir, juntos, conhecimento e (trans)formações preciosas, instituintes, sem pretensão de intencionalidade pautada na racionalidade instrumental.  A imersão no cotidiano escolar da educação infantil na companhia das crianças, de Benjamin e da escrita de mônadas apontou, assim, para reflexões que podem nos inspirar no que tanto desejamos, modos outros de habitar a Terra, a escola, a universidade.
IDENTIDADE NARRATIVA DE PROFESSORAS DA EDUCAÇÃO INFANTIL
Authors: Ferreira de Moura Jónata , Mendes Nacarato Adair
Published: May 2024

O presente artigo é fruto de uma pesquisa biográfic0-narrativa, em que seis professoras de uma pré-escola da Educação Infantil da zona urbana da rede pública municipal de uma cidade do interior do Maranhão narram suas experiências pessoais e profissionais e apresentam indícios de identidade narrativa. O objetivo é compreender a identidade narrativa dessas professoras. Usa-se a entrevista narrativa como dispositivo para a produção de dados, e a análise é realizada a partir da proposta de Fritz Schütze. Os dados revelam que as narrativas autobiográficas representam, expressam e constituem o eu; ajudam a encontrar o fio condutor que estabelece as relações necessárias entre o que a professora da Educação Infantil era e o que é hoje. Pode-se dizer que a narrativa estabelece a mediação entre o passado, o presente e o futuro, entre as experiências e o significado que agora vão adquirindo na relação de seus projetos futuros, constituindo a identidade docente. No ato de narrar, toma-se consciência dessa constituição. As professoras, ao se incorporarem ao grupo de docentes dessa etapa da Educação Básica, vão construindo seus pensares e saberes, as maneiras de pensar e falar do grupo, vão constituindo suas identidades profissionais. A identidade narrativa não é só o que uma pessoa faz ou como os outros a veem, mas é a envergadura para construir uma crônica particular da vida, uma história contínua de si.
Mekânsal kalite unsuru ve kullanıcı beklentileri: Taksim Meydanı ve çevresi
Authors: Ulusay Alpay Bilge
Published: May 2024

Kentin kamusal mekânlarındaki deneyimler ve sosyal ilişkiler, kent kültürünün üretimini oluşturmaktadır. Kentin geçmişine dair izler taşıyan bu mekânlar toplumun hafızasıdır. Ancak, hızlı kentleşme ve artan taşıt kullanımına ilişkin düzenlemelerle birlikte yayalar ikinci plana atılmış ve bu sorunun çözümüne yönelik yayalaştırma çalışmaları dünya çapında ivme kazanmıştır. Bu süreçte, yaya mekânlarında tasarım ilkeleri belirlenerek yayaların fiziksel, algısal ve sosyo-psikolojik sorunlarının giderilmesi hedeflenmiştir. İnsanların mekân içinde kendilerini daha iyi hissetmeleri ve geçirdikleri zamanın kaliteli olması için mekânın yaya odaklı olması önemlidir. Çalışmada, meydanların ve yaya akslarının tasarımına yön veren faktörleri, kalite kriterlerini, donatı elemanlarının tasarım ilkelerini inceleyerek Taksim Meydanı ve yakın çevresinin kullanıcılar tarafından nasıl algılandığını, hangi mekânsal elemanların ön plana çıktığını araştırmak amaçlanmıştır. Bu kapsamda, nitel  verileri elde etmek ve mekânsal kalite için araştırma yöntemi olan literatür taraması yoluyla veri analizi yapılmış, nicel verileri elde etmek için ise gözlem ve anket (sorgulama) yöntemi kullanılmıştır. Bu doğrultuda, kullanıcı memnuniyetini etkileyen faktörler araştırılmış ve mekâna yönelik kullanıcı algılarını ölçmek adına açık uçlu sorular sorulmuştur. Sonuç olarak, Taksim Meydan  ve yakın çevresi kentsel tasarım ilkeleri mekânsal kalite açısından değerlendirilmiştir. Dolayısıyla, yayaların hem fiziksel, hem algısal, hem de psiko-sosyal açıdan olumsuz etkilendiği gözlemlenmiş ve elde edilen veriler dikkate alınarak donatı unsurlarının yetersiz olduğu tespit edilmiştir. Bu çalışmanın bölgede yapılması planlanan, yaşam ve mekân kalitesinin iyileştirilmesine yönelik kentsel tasarım projelerine katkı olabileceği düşünülmektedir.
ENDOVASCULAR TREATMENT BEFORE OPERATIONS IN CLINIC OF TRAUMATOLOGY AND ORTHOPAEDICS
Authors: Prozorov S. , Ivanov P. , Zadneprovsky N.
Published: May 2024

The surgical treatment of arterial injury due to blunt trauma, heterotopic ossification, hemangiomas, aneurysmal bone cysts of skeleton, primary and metastatic bone tumors can lead to uncontrolled life-threating haemorrhage and blood loss. The aim of the present review is to analyze reports of the use and effectiveness of endovascular methods – preoperative embolization and stent graft implantation to reduce surgery risks in clinic of traumatology and orthopaedics.
Endothelial dysfunction in a general practitioner’s work
Authors: Svetlichnaya E. , Skvortsov V. , Levitan B. , Rodionova I. , Shtonda D.
Published: May 2024

Endothelial dysfunction (ED) is a pathological condition that is impairment in the synthesis of endothelial factors and is a major component in the pathogenesis of many diseases, including those of a therapeutic profile. Many specialists now consider ED as a universal component in the development of cardiovascular and respiratory diseases. The paper contains information about the main functions of the endothelium and their impact on the organs and systems of the body, the state of microhemocirculation, and the entire internal environment. It also considers ED that affects vasomotor, hemostatic, adhesive, and angiogenic functions and the main markers of endothelial damage. The possibilities of preventive measures and pharmacological correction of ED are discussed.
Psychodynamic aspects of some cardiac diseases: a cardiologist’s opinion
Authors: Eremeev A.
Published: May 2024

The review considers the psychodynamic aspects of the most common diseases of the cardiovascular system. It analyzes the interrelation of biological, psychological, and social prerequisites during the manifestation of these nosology entities. Particular attention is paid to the dynamic relationship between psychogenesis and somatogenesis within the framework of a psychosomatic continuum of the disease.
The features of clinical and anamnestic indicators, cognitive function, quality of life, and psychological status in patients with various stages of chronic lower extremity ischemia
Authors: Makarov S. , Smirnov K. , Danilchenko Ya.
Published: May 2024

Objective. To estimate the frequency of risk factors and the features of the psychosocial status in patients with atherosclerosis of the lower extremity arteries. Subjects and methods. The investigation prospectively included 198 patients with atherosclerosis of the lower extremity arteries. The patients’ mean age was 67.9±8.0 years. Data copying, questioning, instrumental and analytical methods were used to study the patients’ clinical and anamnestic indicators. The survey was conducted using the SF-36 questionnaire and the SpielbergerKhanin test, Mini-Mental State Examination (MMSE), and Morisky-Green scales. Depending on the stage of ischemia, according to the Pokrovsky-Fontaine classification, the investigators formed two investigation groups: 1) 127 patients with Stage 0–IIA ischemia; 2) 71 patients with Stage IIB-IV ischemia. Results. There was a male preponderance in both groups: 106 men in Group 1 (p=0.03) and 52 in Group 2 (p=0.026). The number of smokers was statistically significantly higher in Group 2 than in Group 1 (37.0 and 49.0%, respectively; p=0.05). No statistically significant differences in diabetes were found between the groups. Systolic blood pressure was also higher in Group 2 than in Group 1 (136.3±15.3 and 130.7±12.9 mm Hg, respectively; p=0.0015). Analysis of physical (p = 0.00019) and psychosocial (p=0.0415) states revealed lower rates in Group 2. Conclusion. The findings suggest that Group 2 patients had more severe clinical, physical, and psychosocial conditions, which indicates the need to attract a psychologist for patients with more severe ischemia, as well as that to more carefully monitor hemodynamic parameters and to correct modifiable risk factors in both groups.
A clinical case of amiodarone- and statin-induced neuropathy with a manifestation of chronic inflammatory demyelinating polyneuropathy
Authors: Zaslavskii L. , Zaslavskaya E. , Petrov M. , Skornyakova E.
Published: May 2024

The paper analyzes the data available in the scientific literature on the frequency and manifestations of the neurotoxic effect of amiodarone and statins on the peripheral nervous system. It shows the need for a differential diagnosis with immune-mediated polyneuropathies. The authors provide a rationale for the early identification of the neurotoxicity of the drugs to minimize neurological complications. The paper describes a clinical case of a 72-year-old male patient who received amiodarone and statins and developed demyelinating polyneuropathy. Amiodarone discontinuation led to a significant regression of neurological complaints.
Implementasi Pelaksanaan Merdeka Belajar-Kampus Merdeka (Studi Pada Mahasiswa Program Studi Pendidikan Akuntansi Universitas Negeri Makassar)
Authors: Amartika Christine Delia , Tikollah M. Ridwan , Azis Muhammad
Published: May 2024

Penelitian ini bertujuan untuk menganalisis implementasi pelaksanaan merdeka belajar-kampus mengajar. Variabel dalam penelitian ini adalah pelaksanaan merdeka belajar-kampus mengajar. Populasi dalam penelitian ini adalah mahasiswa Kampus Mengajar angkatan 3, 4, dan 5 dengan teknik purposive sampling. Pengumpulan data dilakukan dengan menggunakan wawancara dan dokumentasi. Analisis data dilakukan dengan deskriptif kualitatif dengan pendekatan teknik analisis konten. Hasil penelitian ini menunjukkan bahwa: (1) Pendaftaran Asistensi Mengajar di Satuan Pendidikan terdapat dua jenis persyaratan pendaftaran yaitu syarat umum dan syarat berkas. Namun pada pendaftaran angkatan ke 5 terdapat syarat dokumen tambahan yaitu mahasiswa wajib memiliki surat persetujuan dari dosen pembimbing akademik untuk pengkonversian mata kuliah. Adapun kendala yang sering dihadapi selama melaksanakan pendaftaran Asistensi Mengajar di Satuan Pendidikan ialah website yang tidak dapat diakses. (2) Pembekalan Asistensi Mengajar di Satuan Pendidikan diberikan kepada mahasiswa untuk mempersiapkan dirinya sebelum melaksanakan proses penugasan. (3) Pelaksanaan Asistensi Mengajar di Satuan Pendidikan terkandung tugas yang harus dilaksanakan oleh dosen pembimbing lapangan dan guru pamong selama mahasiswa melaksanakan penugasan, terdapat juga ide-ide kreatif yang dilaksanakan mahasiswa selama masa penugasan yang dituangkan dalam program kerja yang mereka kerjakan di sekolah penugasan. (4) Pelaporan hasil kegiatan terdapat jenis dan fungsi laporan kegiatan yang harus dikerjakan oleh mahasiswa. Terdapat juga kendala yang sering dihadapi selama proses pengunggahan laporan kegiatan Asistensi Mengajar di Satuan Pendidikan ialah laman SIM MBKM UNM yang tidak dapat diakses dan error. (5) Penghargaan Asistensi Mengajar di Satuan Pendidikan diperoleh persyaratan pengkonversian mata kuliah dan kendala yang di hadapi mahasiswa selama melaksanakan konversi mata kuliah. Adapun kendala yang sering dihadapi mahasiswa selama melaksanakan pengkonversian mata kuliah yaitu kurangnya informasi dari pihak program studi terkait konversi mata kuliah. Adapun pelaksanaan asistensi mengajar di satuan pendidikan yang dilaksanakan oleh mahasiswa dirasakan adanya factor-faktor pendukung dan penghambat selama kegiatan asistensi mengajar di satuan pendidikan.
MODELOS DE CUIDADO CENTRADOS NO PACIENTE COM EQUIPES MULTIPROFISSIONAIS
Authors: GOMES PATRICK GOUVEA , LOBO EMANUELY VITÓRIA MARQUES , PAIVA SAMARA MACHADO , SILVA LUZINETE COSTA SAMPAIO , ANDRADE JENNYFER SOUZA , BARBOSA CARLOS CESAR , MARTINS DEYLLYSE ALVES FERNANDES , ALVES ERIKA GOMES , GALINDO WICTOR HUGO ALVES , DARIO LARISSA DA SILVA
Published: May 2024

Nos sistemas de saúde contemporâneos, os Modelos de Cuidado Centrados no Paciente
(MCCP) desempenham um papel vital na entrega de serviços de saúde eficazes e
humanizados. Esses modelos reconhecem o paciente como o epicentro do cuidado,
considerando não apenas suas necessidades médicas, mas também seus valores,
preferências e contexto social. No entanto, a implementação bem-sucedida desses
modelos depende crucialmente da colaboração entre profissionais de saúde de diversas
especialidades, conhecida como equipes multiprofissionais. Demonstrar a importância
dos modelos de cuidados aos pacientes e atenção multiprofissional Foi realizada um
revisão integrativa de literatura, com base nos bancos de dados SCIELO E PUBMED, no
recorte temporal de 4 anos, As equipes multiprofissionais representam uma abordagem
interdisciplinar para a prestação de cuidados de saúde, envolvendo médicos, enfermeiros,
fisioterapeutas, assistentes sociais, psicólogos e outros profissionais. Essa diversidade de
especialidades permite uma avaliação abrangente das necessidades do paciente e a
formulação de planos de tratamento holísticos e personalizados. No entanto, embora os
MCCP com equipes multiprofissionais ofereçam inúmeras vantagens, sua implementação
pode enfrentar desafios significativos. A coordenação entre diferentes profissionais e
serviços de saúde pode ser complexa, requerendo sistemas eficazes de comunicação e
compartilhamento de informações. Além disso, as barreiras organizacionais e culturais
podem dificultar a colaboração interprofissional, exigindo um compromisso institucional
e liderança eficaz. Modelos de Cuidado Centrados no Paciente com Equipes
Multiprofissionais desempenham um papel essencial na promoção de cuidados de saúde
de alta qualidade, personalizados e integrados.
TRABALHO MULTIPROFISSIONAL EM ACIDENTES POLITRAUMÁTICOS NOS SERVIÇOS DE URGÊNCIA
Authors: MOURA LORENA CARINE DANTAS , SILVA JUAN VICTOR DA , CARVALHO CAMILA MENDES COSTA , LEONEL LUCIANE RESENDE DA SILVA , LOPES ALINE COSTA , ALVES RODRIGO CABRAL , REIS PEDRO FELIPE MENEZES DOS , JOTER KELCIONE PINHEIRO LIMA , SANTOS THAYNAN DE SOUZA , NASCIMENTO FRANCISCO DIAI SOUSA DO
Published: May 2024

A abordagem multiprofissional visa não apenas tratar as lesões físicas, mas também
considerar aspectos emocionais, psicológicos e sociais do paciente. Médicos,
enfermeiros, fisioterapeutas, psicólogos e outros especialistas trabalham em conjunto
para avaliar, estabilizar e tratar eficazmente as múltiplas lesões, garantindo uma
abordagem holística e centrada no paciente, bem como a atuação destes nos serviços de
urgência e emergência. Demonstrar a relevância do politraumatismo em urgência e
emergência. Trata-se de uma revisão bibliográfica de literatura, com base nos bancos de
dados SCIELO e PUBMED, utilizando os descritores ‘Multiprofissionalismo' e
‘Traumatologia', No contexto do politraumatismo, o trabalho multiprofissional começa
frequentemente nos serviços de emergência, onde a rápida intervenção é crucial. Cada
profissional desempenha um papel específico, desde o diagnóstico preciso até a
administração de tratamentos adequados. A comunicação eficaz entre os membros da
equipe é fundamental para garantir a coordenação e a tomada de decisões rápidas e
precisas. O politraumatismo demanda uma abordagem integrada e coordenada, na qual
profissionais de diversas áreas colaboram para fornecer cuidados abrangentes e
personalizados. O trabalho multiprofissional não apenas trata as lesões físicas imediatas,
mas também considera o impacto emocional e social, contribuindo para a recuperação
completa e a qualidade de vida a longo prazo dos pacientes afetados. Sendo essencial a
visão integrada desses profissionais no atendimento aos pacientes
Palavras-chave: Equipe de saúde, Multiprofissionalismo Politraumatismo.
Transmulticulturalidade na amazônia
Authors: Paixão Shigeaki Ueki Alves da
Published: May 2024

A coletânea Diálogos interdisciplinares apresenta mais uma obra de relevância intitulada Transmulticulturalidade na Amazônia. O conceito de transmulticulturalidade, que busca compreender as dinâmicas culturais da Amazônia a partir de uma perspectiva transdisciplinar, transnacional e transcultural, propõe uma abordagem que reconhece a complexidade, a pluralidade e a interação das culturas na Amazônia, bem como os seus desafios e potencialidades para o desenvolvimento sustentável da região. A transmulticulturalidade também implica em uma postura ética e política de respeito à diversidade cultural e de promoção dos direitos humanos, especialmente dos povos tradicionais e minoritários.
Ao mergulhar nas páginas deste livro, convidamos você a refletir sobre como a esse importante e atual conceito, uma vez que a presente obra desafia as fronteiras tradicionais entre os diversos campos do saber. É uma obra que nos incentiva a olhar para além, uma verdadeira jornada intelectual que nos convida à reflexão sobre a nossa riqueza e diversidade cultural e como ela nos une, nos tornando únicos e ao mesmo tempo múltiplos, plurais, exímios representantes da transmulticulturalidade amazônica.
Neste novo volume, reunimos resultados de pesquisas nos campos da Educação, do direito, do meio ambiente, da sustentabilidade, da interculturalidade, da migração, da formação de professores indígenas e não indígenas, das linguagens, do sistema da informação e outros subcampos com enfoques diversos, que contribuem para o desenvolvimento da pesquisa e da ciência na Amazônia
Trabalho, Sindicalismo e Imigração na Fronteira: Multi-Nacionalidades e Direitos Humanos no Espaço Guyanense
Authors: Batista Ramiro Esdras Carneiro , Domingos Katia Cilene Neres , Lima Gilberto Silva , Jadjesky Izaionara Cosmea
Published: May 2024

A obra que ora apresentamos começou a ser resenhada há uma década, mas, em função do acúmulo de instabilidades como crises políticas e institucionais, pandêmia e sindêmias e, claro, a deblaque do movimento sindical brasileiro experimentado no governo Bolsonaro – jamais foi levada a prelo. Isto acabou por ensaiar o silenciamento de uma memória do movimento social, tido e havido dentre diferentes sujeitos históricos transfronteiriços, que não podemos e não devemos admitir que se materialize no egoísmo de manuscritos, ou em papéis e imagens perdidas em arquivos empoeirados.
Dito isto, cumpre considerar (também) que prevalecem entre os organizadores muitas dúvidas sobre – como e qual – seria o melhor formato para democratizar uma memória e uma história, que possa ser tida como uma tradução didática, cultural e esteticamente adequada, em relação aos eventos e as pessoas neles/as envolvidos/as. Sem conseguirmos dar termo ao dilema, e, sabendo que o formato científico pode não dar conta da necessidade de tradução de uma realidade socialmente produzida e historicamente situada, a partir e com diferentes classes de sujeitos fronteiriços, resolvemos por proceder o registro de experiências da/na realidade em tela a partir de uma publicação de formato livre, híbrido, em alguma medida descolado do formato acadêmico, o que – mal comparando – pode coincidir com os estilos, as vivências e os contructos sociais dos povos e populações que compõem e (re)significam seus arranjos vivênciais de forma não linear.
Agradecemos a todas / todos / todes que conosco colaboraram na organização/consolidação da referida memória, e esperamos que o formato de comunicação aqui proposto atravesse os meandros do inter, do trans e do multicultural, encontrando acolhida nos perfis pluriétnicos e multilíngues que tanto caracterizam as pessoas, os viveres e os fazeres guianenses.

Fronteira Uyapkun, dezembro de 2023.
Os organizadores.
A IMPLEMENTAÇÃO DA COMUNICAÇÃO AUMENTATIVA E ALTERNATIVA COM RECURSOS DE BAIXO CUSTO EM CRIANÇA COM A SÍNDROME DE ANGELMAN
Authors: Rodrigues Luzimara Vieira , Silva Maria Sofia Santos da , Lima Raffaela Silva de , Costa Maria de Fátima Góes da
Published: May 2024

A Síndrome de Angelman (SA), descoberta pelo neurologista
britânico Harry Angelman, é apontada na literatura pela primeira vez em 1965, sendo descrita como uma desordem rara que compromete significativamente todas as áreas que abarcam o desenvolvimento infantil (Silva, 2020). No entanto, as características clínicas que apontam para o
diagnóstico precoce da SA não costumam se manifestar antes do primeiro ano de vida, fato este que tende a adiar o diagnóstico. E, somado a isso, o diagnóstico envolve um processo complexo baseado em análises neurológicas, clínicas e genéticas que perduram por longos períodos (Álvarez; Pico; Vargas, 2022).
Forensic Aspects and Dilemmas in Gynecological Laparoscopy
Authors: Rajko Fureš , Dora Fureš , Žana Stanić , Miroslav Kopjar , Sanja Malinac Malojčić , Martin Gredičak , Tomica Kukina Žvigač
Published: May 2024

Gynecological laparoscopy has to be analyzed also in the context of complications that occur during the surgical procedures. Complications occur daily. For this reason, emphasis should be placed on lifelong continuous education and training. Given the risks and complications we face, we must be trained to deal with them. This improves the safety of laparoscopic operations. Without such certainty, gynecological laparoscopy would not be the method of choice in a minimally invasive approach. This requires significant commitment, effort, and responsibility. In this way, we provide our patients with the best and highest quality healthcare service. Likewise, with such an approach, the frequency of complications is reduced to a minimum. New perspectives and possibilities are associated with the application of robotic surgery.