bluuebunny/crossref_metadata_2025 huggingface dataset:
New Directions for Suicide Prevention Centers*
Authors: Kiev Ari
Published: November 2023

ABSTRACT: This paper considers a number of questions regarding the epidemiology of suicidal phenomena and discusses some of the efforts of the Cornell Program in Social Psychiatry to study these questions and to explore new directions for suicide prevention work. Particular attention is paid to high suicide risk groups that are outside the network of existing medical services. Strategies for extending the clinical picture differentiating between syndromes assessing individual risk, clarifying etiological factors, and improving the working of the health services are considered.
Suicide in Ibsen's Plays
Authors: Lester David
Published: November 2023

ABSTRACT: The suicides and homicides in Ibsen's plays are examined in relation to Hendin's hypotheses about Scandinavian suicide. In general, the suicides had dependency loss characteristics; the victim‐precipitated homicides had characteristics of guilt over transgression, as expected. However, elements of suicide as a vehicle for preserving or restoring an ideal self‐image were also present in many of the characters, suggesting that Hendin's conclusions about the Scandinavians may be oversimplifications.
The Chrysanthemum versus the Sword in Suicide: Yasunari Kawabata and Yukio Mishima
Authors: Iga Mamoru , Yamamoto Joe
Published: November 2023

ABSTRACT: Within the last few years, two world‐famous Japanese writers have committed suicide. Kawabata represents the chrysanthemum aspect of Japanese culture and resignation‐despair. Mishima symbolizes the sword aspect and aggression. Kawabata described loneliness‐helplessness and Mishima an ecstasy under the threat of imminent death. Their different childhood experiences produced an “orphan” complex in Kawabata and the problem of sexual identity with an inferiority complex in Mishima. The former sublimated his complex in literature, the latter overreacted to it. For both, an immediate cause of suicide was the conflict between their ideal and the postwar reality. For Mishima, there were also occasions that gave vital blows to his extremely narcissistic temperament.
Is There a Biochemical Predictor of Suicide?
Authors: Krieger George
Published: November 2023

ABSTRACT: There is a need for additional instruments to alert the clinician more effectively to the high self‐destructive potential of some of his suicide‐risk patients. In this study it was found that suicides‐to‐be tended to have higher plasma cortisols than suicidal patients who did not subsequently commit suicide within two years of the test. The article discusses the possible mechanisms involved and reviews some of the literature indicating that there may be a biochemical substratum that may play a significant role in some suicides.
“Shalom” Means Peace
Authors: Cowan Candace
Published: November 2023

ABSTRACT: This paper is based on firsthand information learned through observation‐participation and speaking with individuals directly involved with postwar activities in Israel. Contacts with psychologists, social workers, and military personnel involved in postwar activities were the sources for much of the information. My personal experiences in Israel during the last 5 years (1969–1974) were the basis for my speculations.
Starting A Therapy Group in a Suicide Prevention and Crisis Center
Authors: Motto Jerome A.
Published: November 2023

ABSTRACT: This report outlines the experience of one center in establishing a group therapy program, discussing the “readiness” of the center, reservations of the governing board, qualifications and number of group leaders, composition of the group, time‐place‐duration of meetings, “open” versus “closed” structure, vagaries of obtaining participants, integration with the 24‐hour telephone crisis service, problems of confidentiality, and dealing with the suicide of a group member.
Acetylshikonin induces apoptosis through the endoplasmic reticulum stress‐activated PERK/eIF2α/CHOP axis in oesophageal squamous cell carcinoma
Authors: Yuan Ya‐Jiao , Liu Shanshan , Yang Hong , Xu Jian‐Ling , Zhai Jing , Jiang Han‐Ming , Sun Beibei
Published: November 2023

Acetylshikonin (AS) is an active component of Lithospermum erythrorhizon Sieb. et Zucc that exhibits activity against various cancers; however, the underlying mechanisms of AS against oesophageal squamous carcinoma (ESCC) need to be elusive. The research explores the anti‐cancer role and potential mechanism of AS on ESCC in vitro and in vivo, providing evidences for AS treatment against ESCC. In this study, we firstly demonstrated that AS treatment effectively inhibits cell viability and proliferation of ESCC cells. In addition, AS significantly induces G1/S phage arrest and promotes apoptosis in ESCC cell lines. Further studies reveal that AS induces ER stress, as observed by dose‐ and time‐dependently increased expression of BIP, PDI, PERK, phosphorylation of eIF2α, CHOP and splicing of XBP1. CHOP knockdown or PERK inhibition markedly rescue cell apoptosis induced by AS. Moreover, AS treatment significantly inhibits ESCC xenograft growth in nude mice. Elevated expression of BIP and CHOP is also observed in xenograft tumours. Taken together, AS inhibits proliferation and induces apoptosis through ER stress‐activated PERK/eIF2α/CHOP pathway in ESCC, which indicates AS represents a promising candidate for ESCC treatment.
Long‐term glucocorticoids in relation to the metabolic syndrome and cardiovascular disease: A systematic review and meta‐analysis
Authors: Kuckuck Susanne , Lengton Robin , Boon Mariëtte R. , Boersma Eric , Penninx Brenda W. J. H. , Kavousi Maryam , van Rossum Elisabeth F. C.
Published: November 2023

The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long‐term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether the findings from the extreme glucocorticoid overabundance observed in Cushing's syndrome could be translated into more subtle variations in long‐term glucocorticoid levels among the general population, for example, due to chronic stress. Here, we performed a systematic review (PROSPERO: CRD42023425541) of evidence regarding the role of subtle variations in long‐term biological stress, measured as levels of scalp hair cortisol (HairF) and cortisone (HairE), in the context of MetS and CVD in adults. We also performed a meta‐analysis on the cross‐sectional difference in HairF levels between individuals with versus without CVD. Seven studies were included regarding MetS, sixteen regarding CVD, and one regarding both. Most articles indicated a strong, consistent cross‐sectional association of higher HairF and HairE levels with CVD, which was confirmed by our meta‐analysis for HairF (eight studies, SMD = 0.48, 95% confidence intervals [CIs]: 0.16–0.79, p = 0.0095). Moreover, these relationships appear largely independent of standard risk factors. Age seems relevant as the effect seems stronger in younger individuals. Results regarding the associations of HairF and HairE with MetS were inconsistent. Altogether, long‐term biological stress, measured as HairF and HairE, is associated with the presence of CVD, and less consistently with MetS. Prospective studies need to evaluate the directionality of this relationship and determine whether HairF and HairE can be used in addition to standard risk factors in predicting future cardiometabolic deterioration.
Effect of recombinant bovine somatotropin on the reproductive efficiency of beef cows subjected to differently timed‐artificial insemination protocols
Authors: Gasseferth Grassiele , Gaievski Francisco Romano , Bergstein‐Galan Tácia Gomes , Júnior Adalberto Gassenferth , Bragato Angelo , Valle Vitor Mohad , Rosa Gabriela Volf Andrade , Souza Fernando Andrade , de Pauli Thomaz Marina , Kozicki Luiz Ernandes
Published: November 2023

This study aimed to verify the reproductive efficiency of beef cows treated with recombinant bovine somatotropin (rbST). Study 1, Bos indicus cows were distributed (three groups). The control group (CG) was subjected: on day zero (d0), the animals received a CIDR and oestradiol benzoate (EB); on (d8, CIDR was removed, and PGF2α and oestradiol cypionate (EC) were administered; on d10, timed Artificial Insemination (TAI) was performed; on d45, pregnancy diagnosis was made. The rbST on d0 group (bST0G) was subjected to an identical protocol as CG, except for the addition of 250 mg rbST on d0. The rbST on d8 group (bST8G) was subjected to the same protocol as bST0G, except that the rbST was administered on d8 rather. In study 2, the animals followed the same design which was used in Bos taurus cows. The follicular growth rate (FGR) was calculated between d8 and d10. In study 1, pregnancy/artificial insemination (P/AI) did not differ among the treatments. FGR in bST8G was higher than in other groups. In study 2, bST0G showed higher Pregnancy/Artificial Insemination (P/AI) (p < .05) when compared with other groups. bST0G showed a different FGR (p < .0001) than the other groups. In conclusion, rbST (Bos indicus cows) did not increase P/AI, but it did promote follicular growth when administered on d8; the rbST administered on d0 improved P/AI (p < .05) and the FGR in Bos taurus cows.
An effective strategy for identifying autogenous regulation of transcription factors in filamentous fungi
Authors: Qin Longguang , Guo Shuhui , Li Ang , Fan Lu , Tan Kaeling , Wong Koon Ho
Published: November 2023

Transcription factors (TFs) play a crucial role in regulating gene expression in living organisms, and any malfunction in their functions can lead to severe physiological consequences. The regulation of TFs occurs at multiple levels, with autogenous regulation being a common mode of regulation where the expression of a TF gene is dependent on its own function. Although bioinformatics analysis of promoter sequences is frequently used to predict autogenous regulation events, it is not entirely reliable. In this study, we present a simple yet effective strategy to identify the autogenous regulation of a TF. We have demonstrated the effectiveness of this method on three fungal TFs (the Carbon Catabolite Repressor CreA and two uncharacterized TFs of secondary metabolism) and have generated a set of plasmids to facilitate the construction of experimental strains in fungi. Our method can be applied to both positive and negative-acting TFs and generalized for other organisms. Hence, this work provides a reliable and straightforward method for identifying autogenous regulation events, which is useful for understanding TFs’ functions.

IMPORTANCE

Transcription factors (TFs) play a crucial role in deciphering biological information from the DNA of living organisms. Improper regulation of their functions can disrupt cellular physiology and lead to diseases in humans. As one of the key regulatory mechanisms, some TFs control their own expression levels through autogenous regulation. However, identifying autogenous regulation events of TFs has been a tedious task. In this study, we present a straightforward approach that provides a reliable means to identify TF autogenous regulation events. Our method provides a valuable means for understanding the function of this important class of proteins in cells.
Supplemental Material: An experimental investigation of the characteristics of cataclastic bands in high-porosity sandstones
Authors: Jiang Mingming , Fu Xiaofei , et al.
Published: November 2023

The main content of the Supplemental Material encompasses the data related to the thickness of deformation bands, particle diameter of host rock and deformation bands, host rock porosity, and the figure related to the 3D models.
Supplemental Material: Origin of Early Cretaceous mafic volcanic rocks from the Erlian Basin west of the Great Xing’an Range of North China: Implications for the tectono-magmatic evolution of East Asia
Authors: Tang Jianzhou , Zhang Zhicheng , et al.
Published: November 2023

Age and geochemical data of the mafic volcanic rocks from the Erlian Basin west of the Great Xing’an Range of North China.
Supplemental Material: Landscape inversion episodes in SE China during the Mesozoic– early Cenozoic: Constrained by trace-element contents, Nd isotope geochemistry, and detrital zircon U-Pb geochronology of sedimentary basins
Authors: He Anbei , YAN Yi , et al.
Published: November 2023

Table S1: Information of samples from Yong’an basin. Table S2: Analysis results of trace elements from Yong’an basin. Table S3: Lithology and Nd isotopic compositions of samples from Yong’an basin. Table S4: Detrital zircon U-Pb geochronology of samples from Yong’an basin. Table S5: Element ratios of samples from Yong’an basin. Table S6: Calculation of denudation rates based on low-temperature thermochronology data.
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Authors: Mak Jonathan K L , McMurran Christopher E , Hägg Sara
Published: November 2023

Background

Many common neurological disorders are associated with advancing chronological age, but their association with biological age (BA) remains poorly understood.

Methods

We studied 325 870 participants in the UK Biobank without a diagnosed neurological condition at baseline and generated three previously-described measures of BA based on 18 routinely measured clinical biomarkers (PhenoAge, Klemera-Doubal method age (KDMAge), homeostatic dysregulation age). Using survival models, we assessed the effect of advanced BA on incident neurological diagnoses, including all-cause and cause-specific dementia, ischaemic stroke, Parkinson’s disease and motor neuron disease.

Results

During a mean follow-up of 9.0 years, there were 1397 incident cases of dementia and 2515 of ischaemic stroke, with smaller case numbers of other diagnoses. The strongest associations with a 1 SD in BA residual were seen for all-cause dementia (KDMAge HR=1.19, 95% CI=1.11 to 1.26), vascular dementia (1.41, 1.25 to 1.60) and ischaemic stroke (1.39, 1.34 to 1.46). Weaker associations were seen for Alzheimer’s disease and motor neuron disease, while, in contrast, HRs for Parkinson’s disease tended to be <1. Results were largely consistent after adjustment for disease-specific covariates including common cardiometabolic risk factors.

Conclusions

Advanced BA calculated from routine clinical biomarker results increases the risk of subsequent neurological diagnoses including all-cause dementia and ischaemic stroke.
Factors associated with bacterial sexually transmitted infections among people of South Asian ethnicity in England
Authors: Dhairyawan Rageshri , Shah Ammi , Bailey Julia , Mohammed Hamish
Published: November 2023

Objectives

Despite being the largest ethnic minority group in England, South Asians have historically had low levels of utilisation of sexual health services (SHS) and sexually transmitted infection (STI) diagnoses, although recent data suggests this may be changing. This study aimed to investigate factors associated with a bacterial STI diagnosis among South Asians attending SHS in England.

Methods

Using data from the GUMCAD STI Surveillance system, a descriptive analysis of South Asians attending SHS in England in 2019 was carried out. Factors associated with a bacterial STI diagnosis were examined using univariate and multivariable logistic regression models adjusted for age, Asian ethnic subgroup, HIV status, patient’s region of residence and Index of Multiple Deprivation quintile. Analyses were stratified by gender and sexual orientation (heterosexual male versus gay, bisexual and other men who have sex with men (GBMSM) versus women of any sexual orientation). Crude and adjusted associations were derived using binary logistic regression.

Results

There were 121 842 attendances by South Asians to SHS in England in 2019. Compared with heterosexual South Asian men, GBMSM had a higher odds of being diagnosed with a bacterial STI (adjusted odds ratio (aOR) 2.32, 95% CI 2.19 to 2.44) and South Asian women had a lower odds (aOR 0.83, 95% CI 0.78 to 0.87). For women and heterosexual South Asian men, a diagnosis was associated with younger age, being of any other Asian background other than Bangladeshi, Indian or Pakistani and not being HIV positive. For heterosexual South Asian men, there was an association with increasing socioeconomic deprivation. For GBMSM, a bacterial STI diagnosis was associated with known HIV-positive status and living in London.

Conclusion

People of South Asian ethnicity in England are heterogeneous with regard to their sexual health needs, which should be explored further through focused research and policy.
Impact of the SARS-CoV-2 pandemic on lung cancer survival in England: an analysis of the rapid cancer registration dataset
Authors: Morgan Helen , Gysling Savannah , Navani Neal , Baldwin David , Hubbard Richard , O’Dowd Emma
Published: November 2023

Early changes in lung cancer care can affect survival. Given the decrease in diagnosis during lockdowns, we calculated their impact on survival using National Lung Cancer Audit data. Percentage survival and HRs for death were compared between 2019 and lockdown periods of 2020. Decreased survival was observed from the first national lockdown onwards and within 90 days of diagnosis. HRs were highest for people diagnosed at the end of 2020 at 1.26 (95% CI 1.20 to 1.32) for death within 90 days and 1.51 (95% CI 1.42 to 1.60) for death between 91 and 270 days. Further work is needed on measures to mitigate this impact.
Variation in spatiotemporal activity may reduce competitive interactions between invasive wild pigs (Sus scrofa) and native mammal species
Authors: Carswell B.M. , Boyle S.P. , Brook R.K. , van Beest F.M. , Vander Wal E.
Published: November 2023

Interactions between sympatric species influence the ecology and behaviour of individuals and species. Invasive species can often alter community dynamics by generating novel pressures that native species are less able to respond to. The scope of these pressures may depend on the ecology and life history of the invasive species. We used remote camera traps to investigate how native mammals’ spatiotemporal activity patterns were altered by the presence of invasive wild pig ( Sus scrofa Linnaeus, 1758). By analyzing patterns of daily activity and implementing Cox proportional hazard models, our results suggest that (a) temporal partitioning may play a role in ameliorating competition between native mammals and wild pigs and (b) native species may be avoiding wild pigs by prolonging their return times to particular sites. We provide an example for monitoring the ecological changes wild pigs may create within ecosystems as they become more abundant in non-traditional ranges.
A Systematic Literature Review on Multimodal Image Fusion Models With Challenges and Future Research Trends
Authors: Ravi Jampani , Narmadha R.
Published: November 2023

Imaging technology has undergone extensive development since 1985, which has practical implications concerning civilians and the military. Recently, image fusion is an emerging tool in image processing that is adept at handling diverse image types. Those image types include remote sensing images and medical images for upgrading the information through the fusion of visible and infrared light based on the analysis of the materials used. Presently, image fusion has been mainly performed in the medical industry. With the constraints of diagnosing a disease via single-modality images, image fusion could be able to meet up the prerequisites. Hence, it is further suggested to develop a fusion model using different modalities of images. The major intention of the fusion approach is to achieve higher contrast, enhancing the quality of images and apparent knowledge. The validation of fused images is done by three factors that are: (i) fused images should sustain significant information from the source images, (ii) artifacts must not be present in the fused images and (iii) the flaws of noise and misregistration must be evaded. Multimodal image fusion is one of the developing domains through the implementation of robust algorithms and standard transformation techniques. Thus, this work aims to analyze the different contributions of various multimodal image fusion models using intelligent methods. It will provide an extensive literature survey on image fusion techniques and comparison of those methods with the existing ones. It will offer various state-of-the-arts of image fusion methods with their diverse levels as well as their pros and cons. This review will give an introduction to the current fusion methods, modes of multimodal fusion, the datasets used and performance metrics; and finally, it also discusses the challenges of multimodal image fusion methods and the future research trends.
Model Self-Adaptive Display for 2D–3D Registration
Authors: Zhang Peng , Miao Yangyang , Shan Dongri , Li Shuang
Published: November 2023

In the 2D–3D registration process, due to the differences in CAD model sizes, models may be too large to be displayed in full or too small to have obvious features. To address these problems, previous studies have attempted to adjust parameters manually; however, this is imprecise and frequently requires multiple adjustments. Thus, in this paper, we propose the model self-adaptive display of fixed-distance and maximization (MSDFM) algorithm. The uncertainty of the model display affects the storage costs of pose images, and pose images themselves occupy a large amount of storage space; thus, we also propose the storage optimization based on the region of interest (SOBROI) method to reduce storage costs. The proposed MSDFM algorithm retrieves the farthest point of the model and then searches for the maximum pose image of the model display through the farthest point. The algorithm then changes the projection angle until the maximum pose image is maximized within the window. The pose images are then cropped by the proposed SOBROI method to reduce storage costs. By labeling the connected domains in the binary pose image, an external rectangle of the largest connected domain is applied to crop the pose image, which is then saved in the lossless compression portable network image (PNG) format. Experimental results demonstrate that the proposed MSDFM algorithm can automatically adjust models of different sizes. In addition, the results show that the proposed SOBROI method reduces the storage space of pose libraries by at least 89.66% and at most 99.86%.
Metaheuristic-Assisted Contextual Post-Filtering Method for Event Recommendation System
Authors: Nithya B. N. , Evangelin Geetha D. , Kumar Manish
Published: November 2023

In today’s world, the web is a prominent communication channel. However, the variety of strategies available on event-based social networks (EBSNs) also makes it difficult for users to choose the events that are most relevant to their interests. In EBSNs, searching for events that better fit a user’s preferences are necessary, complex, and time consuming due to a large number of events available. Toward this end, a community-contributed data event recommender framework assists consumers in filtering daunting information and providing appropriate feedback, making EBSNs more appealing to them. A novel customized event recommendation system that uses the “multi-criteria decision-making (MCDM) approach” to rank the events is introduced in this research work. The calculation of categorical, geographical, temporal, and social factors is carried out in the proposed model, and the recommendation list is ordered using a contextual post-filtering system that includes Weight and Filter. To align the recommendation list, a new probabilistic weight model is added. To be more constructive, this model incorporates metaheuristic reasoning, which will fine-tune the probabilistic threshold value using a new hybrid algorithm. The proposed hybrid model is referred to as Beetle Swarm Hybridized Elephant Herding Algorithm (BSH-EHA), which combines the algorithms like Elephant Herding Optimization (EHO) and Beetle Swarm Optimization (BSO) Algorithm. Finally, the top recommendations will be given to the users.
The interplay between tumor and nodal microenvironments for the formation of nodal premetastatic niche in head and neck cancer
Authors: Mastronikolis Nicholas S. , Spyropoulou Despoina , Kyrodimos Efthymios , Piperigkou Zoi , Giotakis Evangelos , Delides Alexander , Karamanos Nikos K.
Published: November 2023

Head and neck cancer (HNC) encompasses a number of malignancies originating in the head and neck area. In patients with HNC, cervical lymph nodes constitute metastatic sites for cancer cells that escape primary tumors. The premetastatic niche (PMN) is a crucial concept in understanding metastatic disease. PMN refers to the microenvironment resulting mainly from primary tumor cells to foster metastatic tumor cell growth at a distant organ. Tumor microenvironment (TME) plays an important part in the pathogenesis of PMN. A significant prognostic factor is the close association between metastases of lymph nodes and organ dissemination in many different malignancies. The nodal premetastatic niche (NPMN) is a particular type of PMN located within the lymph nodes. NPMN formation is specifically important in HNC as regional lymph node metastasis commonly occurs. The formation happens when tumor cells create a supportive microenvironment within lymph nodes, facilitating their survival, growth, spread, and invasion. This complex mechanism involves multiple steps and cellular interactions between the primary tumor and tumor microenvironment. Several extracellular matrix (ECM) macromolecules, cytokines, and growth factors are implicated in this process. The aim of this article is to present the most recent data on the regulation of the lymph node PMN at molecular and cellular levels in HNC, as well as insights with respect to the relationship between primary tumor cells and the microenvironment of lymph nodes, and the formation of NPMN. We also critically discuss on potential targets for preventing or disrupting nodal metastases and identify potential biomarkers for predicting HNC outcomes.
Usefulness of Sarilumab in Patients with Rheumatoid Arthritis after Regression of Lymphoproliferative Disorders
Authors: Tada Yoshifumi , Maeyama Akira , Hagio Tomonobu , Sakai Mariko , Maruyama Akihito , Yamamoto Takuaki
Published: November 2023

Lymphoproliferative disorders (LPDs) are serious complications associated with rheumatoid arthritis (RA) treatment that mostly occur during methotrexate (MTX) treatment. Cessation of MTX may induce regression of LPDs but is often followed by a flare of RA. Here, we describe two patients with RA flares after the discontinuation of MTX due to LPDs and sarilumab was useful for the treatment of RA without a relapse of LPDs. Patient 1 was an 84-year-old woman, who developed an LPD in the pharyngeal region after 7 years of MTX treatment. Discontinuation of MTX induced regression of LPD but RA flared within 6 months. Administration of sarilumab, in addition to salazosulfapyridine and prednisolone, reduced the RA activity without LPD relapse. Patient 2 was a 76-year-old man, who developed LPD in the pharyngeal region after 5 years of MTX treatment. Discontinuation of MTX induced regression of LPD, but soon RA flared. Although treatment with tocilizumab (TCZ) was effective in controlling RA, it flared again after 2 years. TCZ was switched to sarilumab and RA was in remission. LPD did not recur during these periods.
Dynamic Q-Learning-Based Optimized Load Balancing Technique in Cloud
Authors: Muthusamy Arvindhan , Dhanaraj Rajesh Kumar
Published: November 2023

Cloud computing provides on-demand access to a shared puddle of computing resources, containing applications, storage, services, and servers above the internet. This allows organizations to scale their IT infrastructure up or down as needed, reduce costs, and improve efficiency and flexibility. Improving professional guidelines for social media interactions is crucial to address the wide range of complex issues that arise in today’s digital age. It is imperative to enhance and update professional guidelines regarding social media interactions in order to effectively tackle the multitude of intricate issues that emerge. In this paper, we propose a reinforcement learning (RL) method for handling dynamic resource allocation (DRA) and load balancing (LB) activity in a cloud environment and achieve good scalability and a significant improvement in performance. To address this matter, we propose a dynamic load balancing technique based on Q-learning, a reinforcement learning algorithm. Our technique leverages Q-learning to acquire an optimal policy for resource allocation in real-time based on existing workload, resource accessibility, and user preferences. We introduce a reward function that takes into account performance metrics such as response time and resource consumption, as well as cost considerations. We evaluate our technique through simulations and show that it outperforms traditional load balancing techniques in expressions of response time and resource utilization while also reducing overall costs. The proposed model has been compared with previous work, and the consequences show the significance of the proposed work. Our model secures a 20% improvement in scalability services. The DCL algorithm offers significant advantages over genetic and min-max algorithms in terms of training time and effectiveness. Through simulations and analysis on various datasets from the machine learning dataset repository, it has been observed that the proposed DCL algorithm outperforms both genetic and min-max algorithms. The training time can be reduced by 10% to 45%, while effectiveness is enhanced by 30% to 55%. These improvements make the DCL algorithm a promising option for enhancing training time and effectiveness in machine learning applications. Further research can be conducted to investigate the potential of combining the DCL algorithm with a supervised training algorithm, which could potentially further improve its performance and apply in real-world application.
Incidental Vascular Lesion in Explanted Liver: A Rare Case Report and Review of the Literature
Authors: Kazemimood Rossana , Eliaszadeh Shohreh , Wind Kenneth
Published: November 2023

Hepatic small vessel neoplasm (HSVN) is a rare vascular hepatic lesion that is usually an asymptomatic incidental finding. Here we present a case of a 66-year-old male with HSVN who was discovered to have a lesion presenting as a small nodule in an explanted liver. HSVN is a recently described hepatic vascular lesion that has been previously underdiagnosed. It has an uncertain long-term malignant potential, so close follow-up is recommended.
Approximate Solution of a Class of Highly Oscillatory Integral Equations Using an Exponential Fitting Collocation Method
Authors: Khudhair Abbas S. , Sohrabi S. , Ranjbar H.
Published: November 2023

This paper deals with the numerical solution of a class of highly oscillatory Volterra integral equations by collocation methods based on the exponential fitting technique. By reviewing the oscillatory structures of solutions of these problems, we construct an exponential fitting collocation method which is best tuned to capture the qualitative behaviour of the solution of these equations. We also investigate the convergence properties of the proposed collocation solution based on the interpolation remainder. Some numerical examples are provided which illustrate the efficiency and accuracy of the proposed method and confirm its superiority over the polynomial collocation methods.
Reconocimiento y medición de los derechos y obligaciones relacionados en los contratos de concesión portuaria en Colombia, con base en normas internacionales de Contabilidad (NICS-IFRS)
Authors: Ferrer De la Hoz Angélica María
Published: November 2023

En el presente trabajo se proponen lineamientos para el reconocimiento y medición de los derechos y obligaciones relacionados en el contrato de concesión portuaria en Colombia, tomando como caso a la Sociedad Portuaria Regional de Santa Marta S.A. Los lineamientos propuestos, comprenden políticas contables, directrices y parámetros a seguir, al efectuar los procesos de reconocimiento y medición antes mencionados. De este modo, se da respuesta a la necesidad del sector de contar con referentes prácticos al respecto, debido a que el Estado Colombiano, mediante la Ley 1314 de 2009, manifestó la decisión de tomar la vía de la convergencia en lo relacionado con la aplicación de normas internacionales de contabilidad.
Metodología para valorización de calidad de las estimaciones en la aplicación de las IFRS en Chile
Authors: Aravena Tapia Luis Alberto
Published: November 2023

Este artículo aborda la problemática que las empresas chilenas enfrentan en el proceso de convergencia a las normas internacionales de contabilidad (IFRS), específicamente en los elementos que se deben considerar al valorizar las estimaciones requeridas por las IFRS. Por medio de una revisión del marco de referencia de las IFRS y utilizando el método de caso del proceso de convergencia de una empresa chilena, regulada por la Superintendencia de Valores y Seguros, se fundamenta el problema, identificado el aumento del riesgo de fraude contable en la aplicación de las IFRS. En base al marco de referencia de las IFRS y los hallazgos del método de caso desarrollado, se propone una metodología para la gestión y valorización de calidad de las estimaciones necesarias en la aplicación de la norma contable internacional, con el objetivo de mitigar el riesgo de fraude contable.
Resúmenes analíticos de las tesis del programa de Magíster en Contabilidad y Auditoría, segunda parte
Authors: Caiceo Escudero Jaime
Published: November 2023

Se continúa con la difusión de las tesis realizadas en el Programa de Magíster en Contabilidad y Auditoría de la Universidad de Santiago de Chile, iniciada en el número anterior de Summa de Arithmetica, a través de resúmenes analíticos para que sirvan de fuente para investigaciones futuras, tanto para alumnos como también para la comunidad científica en general. En esta ocasión se presentan 36 resúmenes analíticos de una parte de las tesis realizadas entre los años 2003 y 2011, correspondiendo la mayoría a los últimos tres años. La novedad es que en esta oportunidad se encuentran varias tesis de las dos versiones que se han dado del Programa de Estudiantes de Colombia. Se agrupan en seis áreas: Auditoría (15), Contabilidad (7), Control de Gestión (10), Finanzas (2), Investigación (1) y Sistemas de Información (1); la cantidad en cada área revela el peso que tiene el control -base de la Auditoría-, dentro del Programa, puesto que si se suman las áreas de Auditoría y Control de Gestión se obtiene un 69.4% con ese enfoque.
Radiographic Signs of Advanced Cerebral Venous Thrombosis Negatively Modulate the Effectiveness of Endovascular Treatments
Authors: Chen Huanwen , Khunte Mihir , Colasurdo Marco , Singh Paul , Malhotra Ajay , Gandhi Dheeraj
Published: November 2023

Introduction: Endovascular treatment (EVT) is a therapeutic option for cerebral venous thrombosis (CVT); however, its benefit over conservative medical management has not been proven. Whether the current patient selection practices are appropriate for EVT is unclear. Methods: This was a nationwide study of the 2016–2020 National Inpatient Sample database. Adult CVT patients and EVT treatments were identified. Patient demographics, medical comorbidities, CVT risk factors, and CVT manifestations were identified. Presence of radiographic signs of advanced and severe CVT (venous infarction, cerebral edema, and intracranial hemorrhage) was recorded. Primary and secondary outcomes were good discharge outcomes and in-hospital mortality, respectively. Results: A total of 17,130 CVT patients were identified, and 56.7% had good discharge outcomes, while 4.6% died during hospitalization. 945 (5.5%) received EVT, and EVT patients were more likely to have cerebral infarction (35.4 vs. 21.8%, p < 0.001), edema (35.4 vs. 20.1%, p < 0.001), and hemorrhage (37.6 vs. 19.7%, p < 0.001). After multivariable adjustments, EVT for patients without infarction, edema, or hemorrhage was moderately associated with higher odds of good outcomes (OR 1.86 [95% CI 0.98–3.53], p = 0.059) and resulted in zero deaths. However, with the increasing burden of radiographic signs of advanced CVT measured by the cumulative presence of infarction, edema, and hemorrhage, EVT was associated with decreasing odds of good outcomes and increasing odds of in-hospital mortality compared to medical management (interaction p = 0.046 and 0.029, respectively). Conclusions: EVT may lead to higher rates of favorable hospitalization outcomes in patients who have not yet developed overt parenchymal manifestations of backpressure changes; presence of infarction, edema, and hemorrhage may diminish the short-term effectiveness of EVT.
Governança de plataforma no YouTube: estudo das transmissões ao vivo do Clubinho do King
Authors: Pochmann Pâmela da Silva , Montardo Sandra Portella
Published: November 2023

Este artigo aborda a governança na plataforma YouTube, especificamente nas transmissões ao vivo do Clubinho do King. Seu objetivo é compreender os aspectos de governança da plataforma YouTube que guiam o processo de produção de conteúdo nas transmissões ao vivo do referido clube de leitura. Para isso, mobilizam-se os conceitos de live, plataformas digitais, plataformização e governança no YouTube. O método de pesquisa utilizado é o bibliográfico, com aplicação de questionário junto a duas booktubers responsáveis pelo objeto de estudo. Como resultados, identifica-se que a moderação, o bloqueio e a monetização foram funcionalidades utilizadas e que as lives consistiram em uma estratégia de aproximação das booktubers com o público leitor em relação aos seus próprios canais, e não à iniciativa de leitura conjunta do clubinho.
Rupi Kaur: criação poética em meio às affordances da plataforma Instagram
Authors: Caldeira Júnior Helvio de Araújo , Martins Bruno Guimarães
Published: November 2023

Tomando como base a chamada instapoesia — fenômeno composto por poetas que investem no Instagram para produzir literatura —, o seguinte artigo, parte de uma pesquisa de mestrado na Universidade Federal de Minas Gerais, tem por intuito central analisar a criação poética da artista Rupi Kaur a partir de sua relação com as affordances da plataforma. Interessados nas dinâmicas que envolvem os usos previstos pela mídia social e sua apropriação para fins literários, traçamos uma linha investigativa que passa pela revisão teórica de conceitos como instapoesia e affordance, bem como pelo acompanhamento das postagens de Kaur entre janeiro e fevereiro de 2022. No geral, esperamos ver como a lógica que rege as demais relações no Instagram recai sobre o trabalho de poetas digitais.
“Tu não está sozinho ali”: categorização das dinâmicas de consumo de lives
Authors: Valiati Vanessa Amália Dalpizol , Portolan Cândida Marlei
Published: November 2023

O estudo aborda as práticas relacionadas ao consumo de lives em plataformas digitais, suas implicações individuais e coletivas, sob a ótica da teoria da prática. Busca identificar, analisar e classificar as dinâmicas de consumo relatadas em pesquisa qualitativa, considerando seus aspectos materiais, as competências de uso e a produção de significados. Observa-se o consumo de significados com propósito, a transferência do consumo nos aparelhos culturais para o meio digital, a reconfiguração das capacidades de consumo e a apropriação da live como espaço personalizado de interação. Como resultado, é possível vislumbrar um mapa de práticas atravessadas e recalculadas a todo o momento pelos processos espontâneos, tendo a experiência da liveness como elemento integrador dos eixos.
António: o cartoonista
Authors: Morais-Alexandre Paulo Jorge
Published: November 2023

António Antunes é um dos mais relevantes cartoonistas mundiais. Apresenta uma produção com características muito próprias e com uma extensão significativa, quer nacional, onde colabora com o importante semanário Expresso, quer internacionalmente, com a publicação em periódicos de grande difusão e o averbamento de vários prémios. Ao longo da sua carreira não tem escapado a grandes polémicas, como a havida com Donald Trump, mas lutando sempre por causas que considera justas através da sua Arte.
Comunicação, midiatização e virtualização da vida: domínio e poder na liberdade ilusória
Authors: Nogueira Silas
Published: November 2023

O impulso inicial do artigo veio de uma solicitação para a produção de um texto, com conteúdo, formato e linguagem que pudessem ser trabalhados com alunos de graduação e pesquisadores iniciantes. Deriva dessa solicitação o caráter de rápida revisão de aspectos das teorias da comunicação – entre algumas das mais conhecidas no país – com um encaminhamento destinado a rever alguns autores e linhas de pesquisa no intuito de retomar discussões e conteúdos localizados em um campo crítico e, ao mesmo tempo, ressaltar posturas epistemológicas portadoras de elementos capazes de contribuir para uma leitura também crítica da complexidade que, de forma inseparável, comunicação e sociedade atingiram na atualidade. Assim, comunicação, tecnologias, mídia, midiatização, (tecno)cultura e virtualização aparecem como conceitos (re)vistos e entendidos como necessários para a continuidade da postura crítica na atualidade.
Articulações entre economia criativa, turismo e plataformização
Authors: Cunha Karina Poli Lima da
Published: November 2023

Este texto pretende apresentar algumas reflexões sobre as articulações entre Economia Criativa, Turismo e Plataformização com o objetivo de problematizar a relação entre a participação social na produção e no consumo cultural em duas perspectivas, a produção e consumo cultural local, e a produção de consumo cultural turístico. Partindo de uma contextualização sobre a economia criativa enquanto política pública multifuncional e transversal, procuraremos demonstrar como as articulações entre turismo e desenvolvimento urbano foram sendo incorporadas às políticas culturais e de que forma a plataformização tangenciou esse processo. Em seguida apresentaremos uma breve discussão sobre a participação social na organização do trabalho cultural e criativo e na criação de espacialidades culturais locais que dão origem a novas centralidades urbanas e seus desafios no contexto da economia criativa, para assim discutir a participação social do turista na promoção de centralidades urbanas.
As relações entre ciência e cultura: vinte anos da espiral da cultura científica
Authors: Barata Germana Fernandes , Hafiz Mariana , Oliveira Monique
Published: November 2023

A interação entre os diferentes atores sociais que produzem e consomem a informação científica, que codificam e decodificam essas linguagens para que a comunicação seja efetiva, além das especificidades dessas relações, estão representadas na Espiral da Cultura Científica, um modelo de comunicação da ciência desenvolvido pelo linguista Carlos Vogt há 20 anos. Repensar a espiral a partir da emergência de uma nova doença respiratória causadora de uma crise de saúde pública mundial nos faz refletir sobre a relevância, não só da circulação das informações científicas na esfera pública, mas também do modo com que se deu a apropriação desse conhecimento e seu desenvolvimento contínuo a partir de interações ciência e sociedade. Vogt atua há três décadas fomentando a Divulgação Científica no Brasil. Aos 80 anos completados em fevereiro deste ano, ele tem sido incansável em projetos ambiciosos e pioneiros voltados para ampliar o acesso público ao conhecimento científico. Nesta entrevista, Vogt retoma o conceito da Espiral da Cultura Científica à luz das novas conexões estabelecidas entre ciência e sociedade com a pandemia de Covid-19 quando houve uma ampliação ao acesso público ao conhecimento científico.
Abstract 12523: A Case of Mesalamine Induced Myopericarditis
Authors: El-Mais Ibrahim , Nabil Sultani , Nona Paul
Published: November 2023

Myopericarditis is a condition characterized by concurrent pericarditis and myocarditis, typically with evidence of myocardial involvement detected through elevated cardiac biomarkers or imaging studies indicating abnormal systolic function. Mesalamine is a well-established first-line IBD therapy. It can pose a rare yet serious risk of cardiotoxicity that may be difficult to distinguish from myocarditis presenting as an extra-intestinal manifestation of IBD. We report a case of myopericarditis in an 18-year-old male with newly diagnosed ulcerative colitis who was recently initiated on mesalamine. He presented with chest pain exacerbated by deep inspiration, shortness of breath, fever, palpitations, and elevated troponin levels. In addition to clinical presentation, an echocardiogram indicating left ventricular systolic dysfunction, and CMR revealing edema and late epicardial gadolinium uptake aided in the diagnosis. Prompt recognition and management of cardiovascular side effects associated with mesalamine use is crucial to prevent disease progression and development of complications. Clinicians should educate patients on the possible cardiovascular side effects of mesalamine and instruct them to seek medical attention if they experience any cardiac symptoms.
Abstract 13812: Daily Marijuana Use is Associated With Incident Heart Failure: “All of Us” Research Program
Authors: Bene-Alhasan Yakubu , Osei Albert D , Tammara Anita , Almaadawy Omar , Dwumah-Agyen Matthew , Mensah Samuel , Woldu Bethel
Published: November 2023

Background:
With the increasing state-level legalization of marijuana across the United States, its use has increased exponentially, especially among the youth. However, a lot remains unknown concerning its cardiovascular health implications. We sought to assess the association between the frequency of marijuana use and new-onset heart failure (HF).

Methods:
Using the NIH-sponsored “All of Us” Research Program, we performed a prospective analysis of participants’ survey data and Electronic Health records (EHR). We excluded patients with a baseline EHR diagnosis of HF. Marijuana use was defined as any unprescribed use or if prescribed, use beyond prescribed doses, and was collected using the NM ASSIST instrument. We determined the association between the frequency of marijuana use and incident HF using Cox proportional hazards models adjusted for demographic and socioeconomic factors, diabetes mellitus, hypertension, hyperlipidemia, BMI, alcohol use and smoking status.

Results:
From a final population of 156,999, there were 2958 events within a median follow-up time of 45 months. Compared to never users, daily marijuana users had an increased risk of incident HF (aHR - 1.34, 95% CI 1.04-1.72). In subgroup analyses, frequency of marijuana use was not associated with incident HFrEF nor HFpEF. There was no evidence of effect modification by age, sex at birth nor smoking status. The relationship was attenuated after addition of coronary artery disease diagnosis as a time varying covariate in our main model (aHR - 1.27, 95% CI 0.99-1.62).

Implication:
Data on the cardiovascular effects of marijuana use is limited. To our knowledge this is the first prospective analysis on the association of marijuana use and HF. Our study suggests daily marijuana use is associated with HF. More research into the cardiovascular effects of marijuana is needed to enable clinicians provide the public with high quality information on the health implications of marijuana and to guide policies.