bluuebunny/crossref_metadata_2025 huggingface dataset:
PACIENTES ONCOLOGICOS: CASOS ATENDIDOS NO HOSPITAL ESTADUAL DE URGÊNCIA E EMERGÊNCIA NA 2ª MACRORREGIÃO DE SAÚDE DE RONDÔNIA NO QUATRIÊNIO DE 2019 – 2022
Authors: Holanda Bruna Tainá Aparecida da Silva , Machado Yargo Alexandre de Farias , Chamma Abrahim Merino , Hespanhol Tamiris Tissianel , Borba Mario Nonato , Rosa Ledne Luiz Dalla , Moreno Haroldo Júnior Bianchini , Poche Dierry Weliton Jacob
Published: January 2024

O câncer é caracterizado como doença crônica não transmissível que é uma das causas de morte mais frequentes no Brasil, constituindo um problema de saúde pública na Rede Brasileira de Saúde. O objetivo deste estudo é quantificar e identificar o perfil dos pacientes acometidos pelo CA na macrorregião II que deram entrada na sala vermelha de um hospital referência em urgência e emergência da Amazônia Ocidental. Trata-se de um estudo analítico de dados secundários, revisão bibliográfica com abordagem quantitativa e descritiva exploratória e documental, a amostra foi composta por pacientes admitidos na sala vermelha no HEURO, 41 meses de atendimentos realizados, com total de 3.022 pacientes que deram entrada na sala vermelha com o diagnóstico de CA, 59 foram pacientes com diagnóstico de CA, dentre eles 52,5% eram do sexo masculino, na faixa etária entre 21-75 anos.  2020 foi o ano com mais internações (40,7%) e o ano com menor índice foi o ano 2022 (13,6%). Os tipos de câncer que mais afetam a população rondoniense são os de pulmão, traqueia, cólon, reto e pele não melanoma. Através desses resultados é possível planejar ações preventivas como campanhas de prevenção que é uma educação em saúde realizada ao longo dos anos, a fim de detectar precocemente através de sinais, sintomas e lesões, melhorando também a qualidade de atendimento desses pacientes cometidos por essa patologia, ou efeitos colaterais decorrentes da quimioterápicos ou da própria patologia.
PROBLEMS OF INDUSTRIAL ECONOMIC RESILIENCE ANALYSIS USING FUZZY LOGIC
Authors:   Russian State University named after A. N. Kosygin, Moscow, Russia, Malyukov Yury A.
Published: January 2024

During the analysis of economic resilience of enterprises and industries within existing scientific approaches based on fuzzy sets and soft computing methodology, a number of problems have arisen that require solutions, namely: a) making adjustments to existing linguistic norms of resilience factors; b) incorporating mechanisms of intelligent filtering when forming industry indices; c) improving the accuracy of decision models embedded in the corresponding strategic map. This article describes a series of problematic cases that can be improved within the proposed approaches, including by: a) transitioning from interval membership functions in the classifier to trapezoidal ones; b) excluding noise-contaminated context from the sample that has been rejected based on formal criteria; c) phasifying decision parameters on the strategic map as part of a 4х6 matrix. In the latter case, the technology of pairwise comparison of fuzzy numbers is applied to assess the risk of inefficiency in the decision-making process. It can be formulated that in solving problems related to fuzzy descriptions, we have proposed a series of solutions using the same fuzzy descriptions, but in a more advanced version. In fact, we suggest upgrading a number of previously proven approaches for analyzing economic resilience within the fuzzy scientific paradigm.
OPPORTUNITIES AND CHALLENGES OF ROBOTICS
Authors:   Baikal State University, Irkutsk, Russia, Tatarinov Konstantin A. , Anikienko Nikolai N. ,   Irkutsk State Agrarian University named after A. A. Yezhevsky, Irkutsk district, Russia, Savchenko Inna A. ,   Irkutsk State Agrarian University named after A. A. Yezhevsky, Irkutsk district, Russia, Muzyka Sergei M. ,   Irkutsk State Agrarian University named after A. A. Yezhevsky, Irkutsk district, Russia
Published: January 2024

The increase in labor costs, the shortage of qualified employees, the reduction in the cost of acquiring advanced technologies and the need to find technical solutions to increase competitiveness and strengthen the market position of companies leads to the fact that automation and robotization have become considered by entrepreneurs as business strategies. Opportunities to compete in international markets due only to cheap labor will soon disappear, so the dynamics of global demand for robots and other components of industrial automation in the next few years will remain in double digits. The unemployment rate and the aging of the population are already causing difficulties in finding workers. In some cases, the small scale of production, the wide variety of assortment and the simplicity of the products produced lead to the fact that automation of technological chains does not have sufficient economic justification. However, robotization should not be associated exclusively with mass monotonous production. It can be successfully used in the production of even single products, with a high degree of personalization and higher quality. Mental barriers are a significant obstacle to making a decision on the robotization of production. The article focuses on modern technological changes, as well as the identification of positive and negative consequences of the robotization of the economy.
TRADE AND ECONOMIC COOPERATION OF CHINA OF CHINA WITH RUSSIA. OPPORTUNITIES FOR REALIZING THE POTENTIAL OF IMPORT SUBSTITUTION IN THE ECONOMY OF THE RUSSIAN FEDERATION
Authors:   Senior Researcher, Institute of China and Modern Asia, Russian Academy of Sciences, Professor of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation, Doctor of Military Sciences, Professor, Moscow Russian Federation, Gordienko Dmitry V.
Published: January 2024

The article analyzes the trends in trade and economic cooperation of the People’s Republic of China in the 14th Five-Year Plan (2021 – 2025). China is the world leader in foreign trade. In 2022, the volume of trade between China and Russia in dollar terms increased by 29.3% and reached $190.8 billion, including Russian exports to China of $114.2 billion (43.4% annual growth) and Chinese imports to Russia $76.1 billion (12.8% annual growth). An analysis of the possibilities of the People’s Republic of China to realize the potential of import substitution of all types of products in the economy of the Russian Federation in the future until 2030 suggests that Russian imports from China may increase up to 2025 to 80.82 billion dollars, and up to 2030 – up to 85, 08 billion dollars, which will ensure the implementation of the commodity potential of import substitution in the Russian economy by 84.79% and 89.26%, respectively. At the same time, the accumulated foreign direct investment from China may increase up to 20 billion dollars by 2025, and up to 30 billion dollars by 2030, which will ensure the realization of the investment potential of import substitution in the Russian economy by 12.12% and 18.18% respectively.
ANALYSIS OF CHINESE EXPORTS TO RUSSIA IN 2022–2023
Authors:   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Yuanyuan Fu , Demidenko Daniil S. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Zhaoqun Yu ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia
Published: January 2024

China remains a key trading partner in the context of sanctions against the Russian economy. Chinese brands have seen unprecedented growth, many of them have localized production in Russia to varying degrees. China continues to actively work with the Russian Federation, bypassing sanctions and, largely thanks to Chinese partners, many industries managed to replace the production of certain nodes, which for various reasons Russian manufacturers could not organize. The purpose of this article is to analyze China’s exports to Russia in 2022 and 2023. To achieve this goal, Chinese, Russian and foreign analytical materials and various expert opinions were analyzed.
THE INSTITUTIONAL AND ECONOMIC MECHANISM FOR STRATEGIZING THE DEVELOPMENT OF FINANCIAL LITERACY OF THE POPULATION
Authors:   State organization of Higher professional Education Donetsk National University of Economics and Trade named after Mikhail Tugan-Baranovsky, Donetsk, Bessarabov Vladislav O. , Ilchenko Aleksander A. ,   State organization of Higher professional Education Donetsk National University of Economics and Trade named after Mikhail Tugan-Baranovsky, Donetsk
Published: January 2024

The article proposes an institutional and economic mechanism for strategizing the development of financial literacy of the population, the elements of which are combined into three logically interrelated blocks (theoretical, methodological, practical), suggest two directions of implementation. The first is institutional, related to the development of normative legal acts, recommendations, standards, methods for the development of financial literacy of the population; the creation of institutions and the formation of institutions for the development of financial literacy of the population; the development of financial market infrastructure. The second is economic, it contributes to the formation of a sound system of incentives and motives for the development of financial literacy of the population; providing appropriate resources for the implementation of normative legal acts, recommendations, standards, methods for the development of financial literacy of the population; creating equal conditions for access to the financial market and products sold on it. The process of implementing the proposed mechanism is supported by the proposed structure of the Draft Strategy for the development of financial literacy of the population, the provisions of which consistently reveal the features of its implementation.
МАРКЕТИНГОВЕ ЗАБЕЗПЕЧЕННЯ ДІЯЛЬНОСТІ ПІДПРИЄМСТВ МАЛОГО БІЗНЕСУ
Authors: Морохова Валентина  , Бойко Ольга
Published: January 2024

У статті досліджено особливості маркетингового забезпечення діяльності підприємств малого бізнесу. Встановлено, що найважливішим фактором успішного функціонування та забезпечення конкурентоспроможності вітчизняних підприємств є використання маркетингової концепції управління, яка орієнтує виробників на оперативне реагування на потреби споживачів і їх задоволення ефективніше порівняно з конкурентами. Визначено завдання розширення засобів реалізації маркетингової політики з урахуванням специфіки діяльності підприємств малого бізнесу та актуального стану зовнішнього середовища. Систематизація літературних джерел засвідчила, що розвиток малих підприємств сприяє економічному зростанню, насиченню ринку необхідними якісними товарами, створенню нових робочих місць та вирішенню економічних і соціальних проблем. Узагальнено дослідження щодо зміни умов функціонування малих підприємств та виділено три основні напрями їх розвитку: маркетинг як основа управлінського мислення, маркетинг як управлінська функція та маркетинг як набір спеціалізованого інструментарію. Головною причиною недостатніх маркетингових зусиль малого бізнесу є обмеженість бюджету та інших ресурсів, які можуть бути використані в управлінні маркетинговою діяльністю. Для підвищення ефективності діяльності підприємств малого бізнесу представлено і розглянуто інструменти малобюджетного маркетингу, які є пріоритетними для малого бізнесу. Аргументовано, що «партизанський маркетинг» є економічно ефективною складовою маркетингової стратегії і сприяє зниженню витрат на просування продукції завдяки використанню нестандартних рекламних методів. Дослідження засвідчили: основними особливостями управління маркетингом підприємств малого бізнесу є обмеженість ресурсів та маркетингових функцій, акцент на конкуренцію, креативність та розробку індивідуальних пропозицій для клієнтів. Особливу увагу, на думку авторів, слід приділити питанню організації маркетингової діяльності на малих підприємствах, оскільки вона дозволяє їм встановлювати і підтримувати ефективні контакти зі своїми клієнтами при мінімальних витратах. Основним напрямком швидкої адаптації підприємств малого бізнесу до змін зовнішнього середовища визначено формування ефективної маркетингової стратегії і тактики на базі новітніх маркетингових концепцій і технологій.
Delayed Presentation of Button Battery Ingestion in a 6-year-old Girl – A Case Report
Authors: - M N Hanif Arifin , - S Retinasekharan
Published: January 2024

Foreign body ingestion is a common presentation to Otorhinolaryngology Department (ORL) especially among pediatrics population. Foreign body can be food or non-food related substances. Button battery ingestion is a life-threatening emergency which can cause injuries such as oesophageal strictures, perforations, tracheoesophageal fistulas, mediastinitis and aortoesophageal fistulas. The extent of damage increases with the duration the button battery remains lodged, underscoring the importance of promptly identifying ingestion. We present a case of a child with a delayed presentation of battery ingestion and a complication of esophageal injury.
Podocalyxin Urine sebagai Biomarker Prediktor Nefropati Diabetik
Authors: Orno Theosobia Grace , Pelu Jusni Ekasari
Published: January 2024

Diabetes melitus tipe 2 (DMT2) merupakan penyebab terbanyak dari diabetes, terdiri atas sekitar 85% kasus. Nefropati Diabetik (ND) merupakan salah satu komplikasi dari penyakit diabetes melitus yang dapat berakhir sebagai gagal ginjal. Podocalyxin (PDX) merupakan protein yang diekspresikan dalam podosit ginjal yang berperan dalam menjaga struktur glomeruli. Desain penelitian ini dilakukan dengan metode observasional analitik dengan desain cross sectional. Jumlah sampel sebanyak 25 subjek DMT2 dengan ND dan 25 subjek DMT2 tanpa ND yang diperoleh dengan teknik sampling probability purposive sampling. Penelitian ini dilakukan di Poliklinik Endokrin, Laboratorium Patologi Klinik, Laboratorium Hasanuddin University Medical Research Center (HUM-RC) Rumah Sakit Universitas Hasanuddin Makassar. Subjek DMT2 dengan dan tanpa ND dikategorikan berdasarkan kadar Albumin/Creatinine Ratio (ACR) yang diukur menggunakan metode imunoturbidimetri dan kadar podocalyxin urine diukur menggunakan metode Enzyme-linked Immunosorbent Assay. Hasil penelitian menunjukkan Area Under Curve validitas PDX terukur pada 0,779 dengan derajat kepercayaan 0,685-0,913 (p<0,05). Nilai cut off point sebesar 0,175 ng/mL dengan sensitivitas sebesar 66,7%, spesifisitas sebesar 64,3%. Disimpulkan bahwa PDX dengan nilai kadar 0,175 ng/mL dapat digunakan sebagai biomarker prediktor ND.
MAIN MODELS OF SOCIAL POLICY OF THE STATE
Authors:   Institute of Economics and Management, «Ukraine» University, Kyiv, Ukraine, Poberezhny Oleg
Published: January 2024

The article is devoted to the basic models of social policy of the modem state. It was determined that the functioning of industrialization-type economies objectively required clear regulation of labor relations and corresponding state social policy, which, in turn, determined the need to regulate the social life of society. It is established that in modem conditions one of the priorities of the state social policy is the formation of an effective model of it, which will allow to strike a balance between monetary income of the population and commodity resources, create conditions for solving the housing problem, meeting the demand of the population, increasing its spirituality, education and culture. The implementation of this model of social policy in Ukraine requires not only the tremendous efforts of the state, but also the broad support of the civil society itself. The task of implementing an active model of social policy in our country should be solved today in the interests of ensuring effective social policy, prosperity of our state and citizens in the future. The article states that the level of effectiveness of any model of social policy is expressed only with an appropriate organizational and financial base. Funding of social programs and measures affecting social policy directly depends on the specific weight of expenditures for this industry in the GDP, as well as on the amount of public income. It is shown that the European model of social policy is also distinguished by the importance of the middle class, which is the basis of social stability, the reduction of social tension and the sustainable development of society. In recent years, in European countries, more than 2/3 of the social budget is directed to health care and education, which are especially important for this class. At the same time, the rate of growth of expenses for such purposes is usually quite high. Thus, comparing the social models of modern states, the author emphasizes the choice of the optimal social model for Ukraine.
GLOBALIZATION OF THE LABOR MARKET: DYNAMICS OF MIGRATION FLOWS IN THE CONTEXT OF INTERNATIONAL AGREEMENTS
Authors:   ", Druhova Yevheniia ,   European University",   , Kyiv, Ukraine
Published: January 2024

Research on the labor market within the context of globalization and migration flows remains pertinent in today's globalized world. This article aims to analyze changes in migration processes, particularly their dynamics, directions, and volumes, considering the influence of international agreements. The study illuminates the key trends in migration, taking into account economic, social, and political factors shaping these flows. The investigation elucidates the interplay between globalization, migration, and international agreements, unveiling how global processes impact the development of the labor market. The analysis draws upon a wide spectrum of theoretical sources, ranging from statistical data to scholarly research and documents from international organizations pertaining to migration regulation and agreement formulation. It is crucial to note that the impact of international agreements on migration processes spans various aspects, encompassing human rights, labor migration, and refugee protection. These agreements define rules for border crossings, the status of individuals crossing borders, and the regulation of their employment. In particular, the article scrutinizes the latest trends in migration and their influence on the labor market, specifically within the framework of formulating and executing international agreements related to migration. The article aims to uncover key aspects that aid in a better understanding of globalization's impact on the labor market and in defining strategies for optimal management of migration processes within the context of global economics and regulation through international agreements. Thus, examining migration processes in the context of international agreements allows for comprehension not only of migration dynamics but also of factors influencing these processes, fostering the development of effective migration management strategies. However, it's crucial to acknowledge that the realization of agreements requires joint efforts from countries and partners in the international community to achieve stability and fairness in the migration market.
Forest sector entrepreneurship in Europe – summary of country studies of COST Action E30
Authors: Niskanen Anssi
Published: January 2024

What is COST action E30? COST is an intergovernmental framework for European co-operation in the field of scientific and technical research, allowing the co-ordination of nationally funded research on a European level. COST is formed of Actions, which cover basic and precompetitive research as well as activities of public utility. COST action E30 “Economic integration of urban consumers’ demand and rural forestry production” is one of the largest COST actions thus far under the domain on forests and forestry products. COST action E30 has 21 participating countries: Austria, Bulgaria, Croatia, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Lithuania, the Netherlands, Norway, Poland, Portugal, Romania, Sweden, Switzerland and United Kingdom.
Finland
Authors: Aarne Martti , Hänninen Riitta , Kallio Maarit , Kärnä Jari , Karppinen Heimo , Ollonqvist Pekka , Packalen Katja , Rimmler Thomas , Toppinen Anne , Kajanus Miika , Matilainen Anne , Rutanen Juha , Kurki Sami , Peltoniemi Jukka , Saarinen Jarkko
Published: January 2024

Expanded domestic wood product consumption: The recent increases in apparent consumption of wood products in Finland have occurred in plywood and sawn wood, where the domestic consumption has doubled over the last decade. This is partly due to macroeconomic recovery but the parallel promotion programs on wood use in house construction and repair have also contributed to the development. | Diversified non-industrial forest land tenure and commercial timber production: Private ownership is diversified into small ownership units in Finland. The size distribution of private forest holdings is polarised: fragmentation and parcellisation is going on along with consolidation. The major ownership transfers are through bequests and in recent years only about 10% of the holdings have been sold on the free market. The latter restricts effectively the formation of large-scale ownership and the accompanied possibilities on scale economics in commercial forestry as well as the possibilities of effective timber management investments. Joint efforts have been frequently been applied in silvicultural activities, such as road construction and ditching, to achieve positive scale economics. There are some joint owned forests by non-industrial private forest owners (NIPFs) and these forests are managed commercially by experts.
The Netherlands
Authors: Hoogstra Marjanke , Willems Arno
Published: January 2024

In the Netherlands, all forestry can be considered to be small-scale forestry, irrespective of ownership category and holding size. Therefore, this paper describes current issues in forestry in the Netherlands. Special attention is given to the country’s specific characteristics: great pressure on land from the large population, intensive use of different functions of forests, a high level of public awareness of environmental issues, much detail in the scale of forestry operations, and an intensive public debate on forestry.
Switzerland
Authors: Seeland Klaus , Ballesteros Nicolas , Berger Till
Published: January 2024

Competitiveness of Swiss public forest enterprises is hampered by the fact that there is, by and large, little economic dependence on timber and wood production. Crossfinancing and alternative or other sources of income are more important. Private forest enterprises do well if they are big enough to be economically viable. High level of wages and the low prices in the forest and timber market as compared to other countries is a limiting factor to entrepreneurship. The uncertain development of the forestry sector is not a rewarding perspective for the younger generation to embark on the establishment of forest enterprises. Other sectors of the economy offer better economic alternatives to entrepreneurs. Innovations in the forestry sector bear high uncertainties of success and profit. Externalities of the societal demands in the spheres of recreation, landscape aesthetics and climatic services are taken for granted and are likely not be adequately compensated in future.
CRISIS OF CIVIL DEFENSE IN POLAND. INSTITUTIONAL PERSPECTIVE
Authors: PAWŁUSZKO Tomasz
Published: January 2024

Problemem badawczym podjętym w niniejszym artykule jest kryzys instytucji ochrony ludności na przykładzie Obrony Cywilnej we współczesnej Polsce. Instytucje ochrony ludności stały się ważnymi ogniwami bezpieczeństwa niemilitarnego państw europejskich, szczególnie w obliczu kryzysów migracyjnych oraz pandemii COVID-19. Tymczasem Obrona Cywilna RP pod koniec drugiej dekady XXI wieku uległa marginalizacji. Celem autora jest znalezienie odpowiedzi na pytanie o przyczyny tej nietypowej sytuacji. Chcąc osiągnąć ten cel problem ukazano z perspektywy teorii instytucjonalnej, która ma długą tradycję wyjaśniania procesów zmian instytucjonalnych na gruncie nauk społecznych.
THE FORMATION OF THE PRODUCTIVITY OF MAIZE HYBRIDS DEPENDS ON THE BIOLOGY OF THE FERTILIZER SYSTEM IN THE CONDITIONS OF THE FOREST STEPPE OF THE RIGHT BANK
Authors: Didur Ihor , Tsyhanskyi Viacheslav , Televatyuk Bohdan
Published: January 2024

In the 2022 marketing year, grain prices in Ukraine fell due to port blockades and limited export opportunities. Almost 20% less of the planned volume of corn was exported. Export problems have significantly reduced the price of corn. The opening and continuation of the (grain) corridor stabilized export prices. Instead, the internal price of corn, which, for example, was uniform in Ukraine in 2021, had a wide range in the 2022 season. In addition, the price of seeds, plant protection products and especially mineral fertilizers have increased significantly, which in turn has caused a significant increase in production costs for cultivation, which in turn has encouraged farmers to use alternative elements in the plant nutrition system and the widespread use of biological preparations and biofertilizers different mechanism of action. This article defines the main aspects of optimization of the corn fertilization system due to the combination of soil biological fertilizer Groundfix with mineral fertilizers in the full norm and under the conditions of its reduction by 30%. The production necessity and relevance of the implementation of such technological solutions and the search for optimal options for the maximum economic efficiency of corn cultivation in view of the peculiarities of the conditions that have developed today have been proven. On the basis of the two-year research conducted, it was established that the maximum yield of corn grain in the experiment of 11,48 t/ha in the P8834 hybrid and 11,77 t/ha in the P9074 hybrid was formed on the variant of the experiment where mineral fertilizers were applied at the rate of N120P60K60 (100%) and in pre-sowing cultivation, soil biological fertilizer Groundfix was applied at the rate of 6 l/ha, the yield increase compared to the control in these variants was 0,74 t/ha and 0,89 t/ha. Under the condition of reducing the rate of mineral fertilizers by 30% (N80P40K40) and applying the Groundfix biofertilizer at the rate of 6 l/ha, a fairly high level of corn grain yield was formed at the level of 10,35 t/ha in the P8834 hybrid and 10,83 t/ha in the P9074 hybrid, which has a high positive effect from an economic point of view.
The Conflict Between Palestine and Israel: the Dynamics of International Legal Qualification
Authors:   MGIMO University of the Ministry of Foreign Affairs of Russia, Tolstykh Vladislav L. , Kudinov Aleksey S. ,   MGIMO University of the Ministry of Foreign Affairs of Russia
Published: January 2024

International law has played an ambiguous role in resolving the conflict between Palestine and Israel: on the one hand, the UN General Assembly and Security Council assessed Israel’s activities in the occupied Palestinian territories by applying its rules; on the other hand, it de facto authorised the formation of the state of Israel and the occupation of Palestine in violation of the Palestinians’ right to self-determination. This article is a continuation of other articles published in 2018 in the Russian Law Journal. After summarising the main stages of the conflict’s development and highlighting its elements, the author identifies the features of international law which influence the qualification of the conflict, describes the main instruments used for the qualification, identifies the peculiarities of the legal rhetoric of the both parties, and focuses on the three most important problems of the qualification. He then assesses the prospect of the judicialisation of the conflict (its referral to international courts) and the application of the law of international responsibility to it. In the author’s view, the real regulators of the conflict are military power and political calculations; this conflict therefore reveals two important features of contemporary nternational law: first, it reveals the inherent inefficiency of the secondary rules of international law and its institutional mechanisms, unable to ensure the high values proclaimed by the primary norms; second, it confirms K. Marx’s famous thesis – “Between Equal Rights the Force Decides”. Indeed, the principle of formal equality, which is the very essence of the international order, does not exclude but presupposes recourse to force to resolve conflicts in which each party is able to formulate arguments based on international law.
The Concept of the Economic Basis of the Levy
Authors:   Pepeliaev Group, Zaripov Vadim M.
Published: January 2024

The author proposes that the economic basis of the levy (sbor) should be understood as the need to cover the aggregate costs of authorised persons performing legally significant actions. Meanwhile, the author points to the dual nature of certain payments: a number of levies have elements of both levies and taxes (fiscalisation of levies).
Visual Fake Created Through a Neural Network: Socio-Legal Risks and Problems of Legal Assessment
Authors:   Penza State University, Kapitonova Elena A.
Published: January 2024

The article provides current examples (as of August 2023) of the spread of visual fakes created as a result of using a neural network. Among the socio-legal risks associated with this phenomenon, the following are considered the presence of an effective tool for creating disinformation; the relative ease of using a neural network; the uncontrolled dissemination of the product; undermining of public confidence in the reliability of images and news; a threat to the honour, dignity, and reputation of individuals. The commitment of many national governments to the idea of prohibitions and restrictions on the dissemination of deliberately false information on the Internet, as opposed to the Network Neutrality movement formed in Western society, is stated. The author describes the difference between two basic approaches to countering fakes, conventionally designated as public-legal and private-legal. Russian legislation combines elements of both approaches – state coercion in the form of punishment with the possibility of filing defamation lawsuits. The analysis of the envisaged measures of civil, administrative and criminal liability is supplemented by an indication of gaps in relation to visual fakes created with the help of a neural network. The author presents her own vision of the formulation of the most important issues in this area and outlines possible vectors for their further analysis.
Exploring Relationships Among Cultural Ecosystem Service Values, Spiritual Well-Being, and Life Satisfaction: Implications for the Postpandemic Era
Authors: Choe Yunseon , Lee Woojin , Lin Boyu
Published: January 2024

Cultural ecosystem services significantly affected human well-being in the COVID-19 era. This study investigates visitors’ cultural ecosystem service values at Saguaro National Park (US) and how those values affect tourists’ spiritual well-being and life satisfaction in
the postpandemic era with an exploratory mixed-methods approach. In a qualitative phase using a netnographic analysis of Instagram data (N = 449), seven themes emerged: national environment, learning, socialization, escape and solitude, mental well-being, outdoor recreation during
COVID-19, and tourism during COVID-19. Subsequently, these themes were used to develop and test the proposed hypotheses on data collected from 316 participants of an online survey using partial least squares structural equation modeling. The results disclosed that cultural ecosystem service
values can significantly affect different dimensions of spiritual well-being. This study emphasizes the mediating role of personal and communal spiritual well-being between cultural ecosystem service values and life satisfaction. Further, it bridges the application of real-time social media
surveillance with a content analysis of text and images and a quantitative analysis of qualitative results. The managerial implications provide suggestions for promoting small/medium national parks in the postpandemic era.
Scoping review on remote disease monitoring in rheumatoid arthritis: does it actually help the patient?
Authors: Mruthyunjaya Prakashini , Ahmed Sakir , Danda Debashish
Published: January 2024

Remote monitoring technologies (RMTs) are an emerging tool for assessing, monitoring, and following up on patients with chronic diseases including autoimmune rheumatic diseases (AIRDs). The best use of these exponentially expanding technologies warrants optimum evidence. Rheumatoid arthritis (RA) is a chronic inflammatory process that requires close monitoring of disease activity, response to treatment, and the potential adverse effects. Though there are several studies that have explored RMTs in RA, there is little head-to-head comparison between the individual technologies or the standard of care. Before investing in potentially high-cost strategies like RMTs, it is prudent to estimate their pragmatic role in the management and potentially with long-term follow-up including drug titration. A thorough search of the literature was conducted across PubMed/MEDLINE, Scopus, and WebOfScience databases for recent and relevant literature looking at the acceptance, practical utility, and outcomes in RA using RMTs. This scoping review aims to summarize the current level of evidence in favor of RMTs, estimate real-world benefits and costs, potential hazards and limitations, and finally, identify future studies needed before endeavoring to mainstream RMTs. It emphasizes randomized trials using RMTs, patients reported outcomes and disparities in the usage of RMTs.
Multifaceted aspects of chronic disease: do diffuse idiopathic skeletal hyperostosis affect the quality of life?
Authors: Pellegrino Greta , Giorgi Valeria , Sarzi-Puttini Piercarlo
Published: January 2024

Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition that affects the spine and peripheral joints, characterized by the progressive ossification of ligaments and tendons. It is a non-inflammatory degenerative disease that affects predominantly the elderly population. It has been associated with reduced mobility and chronic pain, which can have a significant impact on patients’ quality of life (QOL). Although DISH has always been considered a benign condition, patients with DISH report higher levels of pain, stiffness, and disability compared to the general population. It can affect their ability to perform daily activities and participate in social and recreational activities. In addition, extra-spinal manifestations such as enthesopathy and involvement of peripheral joints, but still dysphagia and airway obstruction have been described in DISH. These, although not as common, when present result in signs and symptoms significantly impacting the patient’s QOL. The objective of this review is to assess the QOL in individual with DISH. This involves an examination of various facets of the condition, including pain, spinal and extraspinal manifestations, fractures, and metabolic syndrome.
Features of the influence of the antioxidant ethylmethylhydroxypyridine malate and the drug ubidecarenone on plasma concentrations of ubiquinone, ubiquinol and the redox state of coenzyme Q10
Authors: Zozina V. I. , Kondratenko S. N. , Shikh E. V. , Krasnykh L. M. , Melnikov E. S. , Kukes V. G.
Published: January 2024

Relevance. Coenzyme Q10 is one of the main components that maintain the balance of the body's redox regulatory system. Although some studies have examined plasma concentrations of CoQ10 in various diseases, the distribution of ubiquinol and ubiquinone, as well as the redox state of CoQ10, remain largely unexplored. The purpose of the study. The purpose of the study was to study the ratio of ubiquinone and ubiquinol concentrations in patients with chronic heart failure (CHF) administrating the antioxidant ethylmethylhydroxypyridine malate and the domestic drug ubidecarenone (CoQ10 drug). Methods. The study included 58 patients with functional class (FC) of CHF 0−III (according to NYHA), who were divided into 2 groups for subsequent assessment of the effect of ethylmethylhydroxypyridine malate and ubidecarenone on endogenous plasma concentrations of total CoQ10, ubiquinol and ubiquinone. The concentrations of the studied substances were determined by HPLC-MS/MS in the multiple reaction monitoring mode. Results. The study revealed that with additional administration of the drug ubidecarenone, there was an increase in the concentration of coenzyme Q10 (+25.0 Δ%), a significant increase in the concentration of ubiquinol (+43.4 Δ%), as well as a sharp increase in redox state (+74.6 Δ%) compared to the control group. During administration of ethylmethylhydroxypyridine malate in addition to standard therapy, patients experienced a statistically significant increase in the concentration of coenzyme Q10 (+20.22 Δ%), a significant increase in the concentration of ubiquinol (+25.0 Δ%) and ubiquinone (+17.7 Δ%) according to compared with a control group receiving standard therapy. Conclusion. With the additional administration of ethylmethylhydroxypyridine malate and ubidecarenone to standard therapy, a statistically significant increase in the concentration of total CoQ10 is observed. However, when administrating ubidecarenone, a sharp increase in the redox state of CoQ10 is observed due to its reduced form — ubiquinol. While during administration of ethylmethylhydroxypyridine malate, it is observed an unreliable but positive trend towards an increase in the redox state of CoQ10 due to a statistically significant increase in the concentration of both ubiquinone and ubiquinol.
Acute toxicity study of a new dibenzofuran oxime derivative GIZH-272 in mice
Authors: Alekseeva S. V. , Sorokina A. V. , Volkova A. V. . , Miroshkina I. A. , Kachalov K. S. , Alekseev I. V. , Zakharov A. D. , Durnev A. D.
Published: January 2024

Relevance. Acute toxicity testing is a common procedure for preclinical safety testing of potential agents. The purpose of this study was to study the acute toxicity of the compound GIZH-272, a new dibenzofuran oxime derivative with anti-ischemic and anticonvulsant effects. Methods. The compound was administered to mice intraperitoneally and orally once. Within 14 days, the condition of the animals was monitored, clinical manifestations of intoxication were recorded, and changes in the dynamics of body weight and its growth were recorded. Results. It was found that the test compound at maximum doses did not lead to the death of mice. Therefore, the data obtained according to the classification of Sidorov K.K. (1973), make it possible to attribute GIZH-272 to the 5th class of toxicity — "practically non-toxic substance". In accordance with GOST 12.1.007-76, the GIZH-272 compound belongs to the 4th hazard class (low-hazard substance) for oral administration.
In-vitro dissolution profiles comparison for various drugs with active ingredient Febuxostat commercially available on the Russian market
Authors: Denkina S. V. , Gadaev M. Y. , Grebenkin D. Yu. , Ryabova A. V. , Kislyakov I. V.
Published: January 2024

Introduction. Gout treatment drugs are widely represented on the pharmaceutical market of the Russian Federation, including those with INN febuxostat. These drugs differ in excipients composition, in the dosage form (tablets and capsules) and production technology. The Dissolution Kinetics Test was chosen to assess the rate and extent of active ingredient release for drugs with INN febuxostat for different manufacturers as in vitro test dissolution allows to suggest the release from the dosage form in vivo. The rate and percent of active substance release are factors that have a direct impact on the bioavailability of drugs. Drug release was studied in a phosphate buffer solution pH 6.8, sampling was carried out at time points 0 min, 5 min, 10 min, 15 min, 20 min, 30 and 45 min. The analysis of the obtained solutions was carried out using the UV spectrophotometry method at a wavelength of 317 nm. The comparison of dissolution profiles was carried out in accordance with the requirements of Decision of the Council of the Eurasian Economic Commission dated November 3, 2016 N 85 "On approval of the Rules for conducting bioequivalence studies of medicinal products within the framework of the Eurasian Economic Union". The purpose of the study. The purpose of this study was to compare the kinetics of the release of the active substance febuxostat from drugs registered in the territory of the Russian Federation in the form of tablets and capsules. Materials and methods. Drug release studies were performed using the Sotax dissolution tester AT Xtend, Switzerland. Each drug was analyzed in 12 repetitions in a pH 6.8 phosphate buffer dissolution medium, on a "Paddle apparatus", special sinkers were used for capsule dosage forms. The selected samples were analyzed on a Shimadzu UV 1800 UV spectrophotometer, Japan, at a wavelength of 317 nm. Results. Dissolution profile studies for three drugs with the active substance febuxostat were conducted in a phosphate buffer solution pH 6,8. For the studied drugs, the release of febuxostat was observed to be more than 85 % at 15 minutes. The release profiles can be recognized as equivalent without further mathematical processing. Conclusion. Based on the results of dissolution profile studies, no differences were found in dissolution profiles of febuxostat from drugs with different dosage forms (tablets and capsules).
MODERN UNDERSTANDING OF THE PATHOGENESIS OF PREECLAMPSIA
Authors: Dobrokhotova Yulia Eduardovna , Borovkova Ekaterina Igorevna , Klauschuk Vladislava Igorevna
Published: January 2024

Preeclampsia today remains one of the leading causes of adverse maternal and perinatal outcomes. The article highlights the main theories and new data on the pathogenesis of this formidable complication of pregnancy. Understanding the complex mechanisms of pathogenesis is a prerequisite for providing qualified assistance to the mother and fetus.
Tactile cues are more intrinsically linked to motor timing than visual cues in visual-tactile sensorimotor synchronization
Authors: Huntley Michelle K. , Nguyen An , Albrecht Matthew A. , Marinovic Welber
Published: January 2024

Many tasks require precise synchronization with external sensory stimuli, such as driving a car. This study investigates whether combined visual-tactile information provides additional benefits to movement synchrony over separate visual and tactile stimuli and explores the relationship with the temporal binding window for multisensory integration. In Experiment 1, participants completed a sensorimotor synchronization task to examine movement variability and a simultaneity judgment task to measure the temporal binding window. Results showed similar synchronization variability between visual-tactile and tactile-only stimuli, but significantly lower than visual only. In Experiment 2, participants completed a visual-tactile sensorimotor synchronization task with cross-modal stimuli presented inside (stimulus onset asynchrony 80 ms) and outside (stimulus-onset asynchrony 400 ms) the temporal binding window to examine temporal accuracy of movement execution. Participants synchronized their movement with the first stimulus in the cross-modal pair, either the visual or tactile stimulus. Results showed significantly greater temporal accuracy when only one stimulus was presented inside the window and the second stimulus was outside the window than when both stimuli were presented inside the window, with movement execution being more accurate when attending to the tactile stimulus. Overall, these findings indicate there may be a modality-specific benefit to sensorimotor synchronization performance, such that tactile cues are weighted more strongly than visual information as tactile information is more intrinsically linked to motor timing than visual information. Further, our findings indicate that the visual-tactile temporal binding window is related to the temporal accuracy of movement execution.
Texture congruence modulates perceptual bias but not sensitivity to visuotactile stimulation during the rubber hand illusion
Authors: Lanfranco Renzo C. , Chancel Marie , Ehrsson H. Henrik
Published: January 2024

The sense of body ownership is the feeling that one’s body belongs to oneself. To study body ownership, researchers use bodily illusions, such as the rubber hand illusion (RHI), which involves experiencing a visible rubber hand as part of one’s body when the rubber hand is stroked simultaneously with the hidden real hand. The RHI is based on a combination of vision, touch, and proprioceptive information following the principles of multisensory integration. It has been posited that texture incongruence between rubber hand and real hand weakens the RHI, but the underlying mechanisms remain poorly understood. To investigate this, we recently developed a novel psychophysical RHI paradigm. Based on fitting psychometric functions, we discovered the RHI resulted in shifts in the point of subjective equality when the rubber hand and the real hand were stroked with matching materials. We analysed these datasets further by using signal detection theory analysis, which distinguishes between the participants’ sensitivity to visuotactile stimulation and the associated perceptual bias. We found that texture incongruence influences the RHI’s perceptual bias but not its sensitivity to visuotactile stimulation. We observed that the texture congruence bias effect was the strongest in shorter visuotactile asynchronies (50–100 ms) and weaker in longer asynchronies (200 ms). These results suggest texture-related perceptual bias is most prominent when the illusion's sensitivity is at its lowest. Our findings shed light on the intricate interactions between top-down and bottom-up processes in body ownership, the links between body ownership and multisensory integration, and the impact of texture congruence on the RHI.
Gıda İşleme ve Üretiminde Yenilikçi Teknolojiler
Authors: Aydın Ebru , Karacabey Erkan , Küçüköner Erdoğan , Özkan Gülcan , Buzrul Sencer , Baltacıoğlu Hande , Coruk Katibe Sinem , Doğanay Gözde , Yetişen Mehmet , Yavuzer Emre , Uslu Hasan , Gündoğan Büşra Nur , Alagöz Eda , Sarıçoban Cemalettin , Alagöz Eda , Var Ganime Beyzanur , Özer Cem Okan , Demir Özer Ezgi , Babaoğlu Ali Samet , Ünal Kübra , Çetin Babaoğlu Hümeyra , Demirci Talha , Yetişen Mehmet , Tangüler Hasan
Published: January 2024

OHMİK Isıtma Tekniğinin Gıda Teknolojisi İçerisindeki Yeri ve GeleceğiEbru AYDINErkan KARACABEYErdoğan KÜÇÜKÖNERGülcan ÖZKAN
Gıda Sanayinde Vurgulu Elektrik Alan UygulamalarıSencer BUZRUL
Gıda Analizinde FTIR Spektroskopisinin KullanımıHande BALTACIOĞLUKatibe Sinem CORUKGözde DOĞANAY
Gıda Kalite Belirlemede Elektronik Burunlar ve Makine ÖğrenmesiMehmet YETİŞENEmre YAVUZERHasan USLU
Balığın Tazelik Kalite Özelliklerini Değerlendirmede Bazı Yeni TekniklerBüşra Nur GÜNDOĞANEda ALAGÖZCemalettin SARIÇOBAN
Deniz Ürünleri İşleme Teknolojisinde Yenilikçi EğilimlerEda ALAGÖZBüşra Nur GÜNDOĞANCemalettin SARIÇOBAN
Et ve Et Ürünlerinde Ultrases TeknolojisiGanime Beyzanur VARCem Okan ÖZER
Gıda Tasarımında Üç Boyutlu (3D) Baskı UygulamalarıEzgi DEMİR ÖZER
Et Endüstrisine Güncel Alternatifler: Et Analogları ve Yapay EtAli Samet BABAOĞLUKübra ÜNAL
Modifiye Bitkisel Protein İzolatlarının ÜretimiHümeyra ÇETİN BABAOĞLU
Yeni Nesil Probiyotiklerin Üretim ve Uygulamalarında Karşılaşılan Zorluklar ve Çözüm YollarıTalha DEMİRCİ
Bazı Geleneksel Türk Fermente Ürünleri ve Yenilikçi YaklaşımlarMehmet YETİŞENHasan TANGÜLER
Nanoteknolojinin Gıda Ürünleri Üzerindeki KatkısıMehmet YETİŞENCem BALTACIOĞLUHasan USLU