bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating levels of Interferon regulatory Factor-5 correlates with disease activity in Systemic Lupus Erythematosus Iraqi patients
Authors: Dahham Zainab M. , Haddad Namir I. A.
Published: January 2023

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a diversity of the phenotypes among the patients. SLE is still one of the great challenges due to the lacking of specific biomarkers for diagnosis, assessing disease activity, and prediction of response to therapy. This study aimed to investigate the role of circulating levels of IRF5 protein in sample of SLE Iraqi patients and its correlation with disease activity, to identify a potential immunological biomarker to mirror disease activity.

Methods: Blood samples were taken from 59 participants diagnosed with SLE cases classified according to the American College of Rheumatology (ACR) criteria. They were scored through the SLE disease activity index 2000 (SLEDAI-2K) to estimate the disease activity, and according to it they were subdivided into “SLE-1 group” (SLEDAI-2k ≤5), and “SLE-2 group” (SLEDAI-2k >5), as well as age and gender matched healthy control group. Circulating levels of IRF5 protein were measured in sera samples by ELISA method.

Results: Our result revealed that the circulating levels of IRF5 protein were significantly higher in the SLE-2 group rather than control group (p<0.01), while there was a non-significant difference between SLE-1 group and control group (p>0.05), as well as between both SLE patient groups. Moreover, the circulating IRF5 protein levels were found to be correlated positively and significantly with disease activity index in both SLE patient groups. The correlation between the circulating levels of IRF5 protein with other parameters revealed that a significant positive correlation was found in SLE-1 group with ESR and globulins, and negative correlation with Hb and (albumin/ globulin) ratio, while in SLE-2 group were positively correlated with urea, creatinine, and uric acid. The analysis of receiver operator curves (ROC) for circulating levels of IRF5 protein in SLE-1 and SLE-2 groups showed a good accuracy to distinguish SLE patients from healthy individuals (AUC=0.758, sensitivity=65.5%, and specificity=69%,), and (AUC=0.788, sensitivity=77.3%, and specificity=72.0%,), respectively.

Conclusions: The circulating levels of IRF5 protein correlate with disease activity in SLE patients reflects the possibility of using it as a potential immunological biomarker for diagnosis, and monitoring the disease activity.
Placas aislantes de EPS reciclado: factores críticos y potencialidades para la viabilidad productiva de un emprendimiento en el Partido de La Plata
Authors: Reynoso Laura Elena , Viegas Graciela Melisa , San Juan Gustavo Alberto
Published: January 2023

Previous research has allowed developing and characterizing an expanded polystyrene waste (EPS) based insulation material that can be used to manufacture plates, providing job opportunities to unemployed or vulnerable social groups. By working together with a local recycling cooperative, the production processes needed for their manufacture on a scale suitable for commercialization were determined. The goal of this research is to analyze these production processes and identify the critical aspects that make the technology’s implementation and management viable. The methodology used involves i. the product’s adaptation; ii. determining supplies and resources for its feasibility; iii. detecting the most critical production processes; and, iv. adapting to the particular case of application. A set of minimum requirements is obtained to develop a productive venture. In addition, the most critical processes related to the separation and obtaining of the EPS and its continuous supply over time, are identified. The results summarize contributions to replicate and make this experience sustainable.
Structural risk minimization for quantum linear classifiers
Authors: Gyurik Casper , Vreumingen, van Dyon , Dunjko Vedran
Published: January 2023

Quantum machine learning (QML) models based on parameterized quantum circuits are often highlighted as candidates for quantum computing's near-term “killer application''. However, the understanding of the empirical and generalization performance of these models is still in its infancy. In this paper we study how to balance between training accuracy and generalization performance (also called structural risk minimization) for two prominent QML models introduced by Havlíček et al. \cite{havlivcek:qsvm}, and Schuld and Killoran \cite{schuld:qsvm}. Firstly, using relationships to well understood classical models, we prove that two model parameters – i.e., the dimension of the sum of the images and the Frobenius norm of the observables used by the model – closely control the models' complexity and therefore its generalization performance. Secondly, using ideas inspired by process tomography, we prove that these model parameters also closely control the models' ability to capture correlations in sets of training examples. In summary, our results give rise to new options for structural risk minimization for QML models.
Extending the fair sampling assumption using causal diagrams
Authors: Gebhart Valentin , Smerzi Augusto
Published: January 2023

Discarding undesirable measurement results in Bell experiments opens the detection loophole that prevents a conclusive demonstration of nonlocality. As closing the detection loophole represents a major technical challenge for many practical Bell experiments, it is customary to assume the so-called fair sampling assumption (FSA) that, in its original form, states that the collectively postselected statistics are a fair sample of the ideal statistics. Here, we analyze the FSA from the viewpoint of causal inference: We derive a causal structure that must be present in any causal model that faithfully encapsulates the FSA. This provides an easy, intuitive, and unifying approach that includes different accepted forms of the FSA and underlines what is really assumed when using the FSA. We then show that the FSA can not only be applied in scenarios with non-ideal detectors or transmission losses, but also in ideal experiments where only parts of the correlations are postselected, e.g., when the particles' destinations are in a superposition state. Finally, we demonstrate that the FSA is also applicable in multipartite scenarios that test for (genuine) multipartite nonlocality.
Bilingualism as an independent variable in the education of national minorities in the example of Slovakian national minority in Vojvodina
Authors:   University of Novi Sad Faculty of Education in Sombor,Serbia, Černak Ruženka Šimonji , Beljanski Mila ,   University of Novi Sad Faculty of Education in Sombor,Serbia
Published: January 2023

The Slovakian people in Vojvodina are an autochthonous minority with command of both Slovakian and Serbian language. The Constitution of the Republic of Serbia enables them to receive education in their mother tongue. The task of this paper is to analyse how the SlovakSerbian bilingualism affects the process of education in children whose mother tongue is Slovakian. The starting point is the fact that education of children who belong to national minorities is specific due to choice of their official medium of instruction, change of the medium of instruction, adapting to the majority language, learning of the majority language and development of intercultural competences. Within these specific aspects, throughout this paper, we have showcased various research conducted in the past 20 years. These research deal with the choice of the medium of instruction, influence of the change of the medium of instruction on academic achievement, adaptation to Serbian language in the secondary school, learning the majority language as core subject and research on bilingualism as a factor of developing interculturality of children. Based on the results we can attempt answer to a question of how Slovakian-Serbian bilingualism affects the educational path of the Slovak national minority in Vojvodina
Self-regulation and Tolerance for Uncertainty as Resources for the Subjective Well-being of Modern Youth: A Cross-cultural Aspect
Authors: Banshchikova Tatiana N. , Sokolovskii Maksim L. , Korosteleova Tatiana V.
Published: January 2023

The study of the socio-cultural specifics of subjective well-being, its determinants and resources are an important task of modern psychology. The authors present the results of an empirical study, the purpose of which is to identify the features of the relationship between conscious self-regulation and tolerance for uncertainty and subjective well-being in young people of different ethnic groups. The study involved 1435 respondents aged 18-35 from five regions of Russia (Karachay-Cherkess Republic, Kabardino-Balkarian Republic, Republic of North Ossetia - Alania, Stavropol Territory, Moscow and the Moscow Region), belonging to the dominant ethnic groups in them. The design of the empirical study included an assessment of differences in indicators of subjective well-being, tolerance or intolerance for uncertainty and conscious self-regulation among various representatives of ethnocultural groups, as well as an analysis of the relationship between these indicators, in particular, using structural modeling. The results obtained confirm the influence of the cultural context of income on the level of subjective well-being. Less prosperous, as they consider themselves, are young people from ethnic groups where the socio-economic situation of the region does not provide opportunities for self-realization of the individual. The study has revealed two types of regulatory profiles: (1) a profile with a harmonious structure with a relatively pronounced general level of self-regulation, which is observed among the Russian respondents from Moscow and the Moscow region; and (2) a relatively accentuated profile, characteristic of Karachays, Circassians, Ossetians, and Russians (from the Stavropol Territory), expressed in the desire for a clear programming of their actions, their compliance with certain norms. It has been established that young people from the southern republics are less tolerant of uncertainty: they tend to solve problems in a situation of uncertainty in a ‘ready-made’ algorithm determined by traditions. Finally, the authors reveal the structure of relationships between the predictors of subjective well-being, which are presented in the form of models. The central place in these models belongs to conscious self-regulation and its basic cognitive-regulatory processes and personal-regulatory properties, which, both directly and indirectly, due to the mediator role of tolerance or intolerance for uncertainty, affect the subjective well-being of young people. The results of the study contribute to a deeper understanding of the ethno-regional specificity of the predictors of the subjective well-being of today’s youth and can serve as a basis for assisting in constructing interaction with representatives of other cultures and developing strategies for actively overcoming difficulties in a situation of uncertainty.
Objective Methods in the Assessment of Child Language Development in Natural Settings and Using Testing
Authors: Zhukova Marina A. , Manasevich Victoria A. , Golovanova Irina V. , Letyagin Pavel I. , Ulianova Taisia A. , Tikhonova Sofia S.
Published: January 2023

The authors describe the application of various approaches to the assessment of child language development reviewing the methods most widely used in research and clinical practice. The review outlines the benefits and some limitations of longitudinal method of assessment using language recordings, language corpus analysis and transcripts of speech samples. Technical aspects of the linguistic environment recordings using LENA technology, which allows to achieve ecologic validity in the assessment of children’s language environment, are considered. Analysis of the corpus data through the transcription of the dialogues between children and adults are discussed, as well as the study of linguistic parameters of child speech in comparison to a normative group of peers. The authors offer a review of the most widely known parent reports, questionnaires, and maximum performance testing of children’s language development. Among the assessment tools available for Russian-speaking populations McArthur-Bates CDI and PLS-5 are reviewed. The authors note an importance of integration of Russian research into the international scientific knowledgebase through the adaptation of methods for assessment of language development in children.
ACTUALIZATION OF CUSTOMER IMPRESSION FORMATION IN THE HOSPITALITY INDUSTRY
Authors:   Южный федеральный университет, Павел Евгеньевич Будаев , Вероника Сергеевна Власова ,   Южный федеральный университет
Published: January 2023

The attention to the presented research topic is based on the growing dominance of the individual's needs in getting an impression in all sectors of the economy and, especially, in the hospitality industry. However, the absence of a developed discourse on this problem emphasizes the existence of a real contradiction between the theoretical understanding of the problem and a person’s growing interest in satisfying his emotional needs. In this regard, the subject of analysis in this context is the peculiarities of perception as a psychological phenomenon of consumers of the hospitality industry. The goal is an unconditional requirement to reveal the instrumental significance of impressions in the development of the competitive ability of the hospitality industry as one of the flagships of the domestic economy. The methodological resource should include a number of methods used, such as analytical, descriptive, the method of gestalt psychology, instrumental, in general, which allowed reconstructing the ways of creating and managing the impression of individuals. The source material used in the article can be conditionally differentiated in two directions: psychological and material on the economics of impressions. Of particular importance for the realization of the goals were the works described below, relating to the analysis of open and closed gestalt images, as well as to the description of the features of self-expression and self-presentation of the individual, her interest in the game as one of the ways of life. It can be considered a new promising scientific direction with multidimensional aspects of impression economics. This direction should include the monographs "The Economy of Impressions" by authors Pine and Gilmort, the work of A. Slivotsky "Migration of values", the article by V. Pekar "Introduction to the economy of Impressions", etc. In the context, the emphasis is placed on the statement of the emergence of a new value, which is the impression, prevailing in the scientific body of literature on a tourist destination. This statement, from the point of view of the authors, is debatable. The argumentation given here against this statement, of course, cannot be assessed as absolute truth, but only as the initial moment of scientific controversy. The article presents psychological techniques, the use of which can greatly increase the interest of individuals in obtaining new impressions by an individual in a tourist destination. The practical value consists in demonstrating techniques, the creative understanding of which can enable the hospitality industry to increase its economic status.
SOCIAL ENTREPRENEURSHIP AS A MECHANISM FOR ESG-TRANSFORMATION IN THE CONTEXT OF SUSTAINABLE DEVELOPMENT
Authors:   Гомельский государственный университет им. Ф. Скорины, Гомель, Беларусь, Наталья Федоровна Кадол
Published: January 2023

In modern conditions the problem of searching new effective mechanisms for solving social and economic problems, leveling of social differentiation, achievement of sustainable development goals becomes actual. In this connection the article considers the questions connected with the role of social entrepreneurship in achievement of sustainable development and ESG-transformation of business processes. The tendencies connected with changes in hierarchy of importance of strategic goals of corporate management are noted, showing the importance of interaction and development of new forms of partnership in solving social problems. In particular, the importance of involvement of subjects of social entrepreneurship in the practice of such interaction as the S-factor of ESG-triad of business process transformation is noted.
ARTIFICIAL INTELLIGENCE AS A FACTOR OF INCREASING THE INTERNATIONAL COMPETITIVENESS OF A COMPANY (ON THE EXAMPLE OF ALPHABET)
Authors:   Национальный исследовательский университет «Высшая школа экономики» (НИУ ВШЭ), Москва, Россия, Татьяна Георгиевна Философова
Published: January 2023

Over the past 5 years, such areas of company development as high technology have become increasingly popular. Companies are increasingly using blockchain, augmented reality, robotics, artificial intelligence, and other innovations in their activities. It is worth noting that there are already many studies aimed at studying the relationship between high technology and the growth of the company's performance. This paper investigates the impact of the use of artificial intelligence on improving the competitiveness of the company. For a more accurate understanding, the Alphabet case was taken. The work used company data before and after the introduction of artificial intelligence. In addition, data from leading companies in the high-tech market for a certain period of time were also considered to build a regression. Furthermore, we will obtain findings which show the dependence of the company's high competitiveness on the use of artificial intelligence in its activities. Since we will consider the causal factors of such dependence, our results can be useful for novice startups, as well as large market players to understand trends and benefits from the development of artificial intelligence in their enterprise.
DIGITALIZATION AS A RISK FACTOR FOR THE DEVELOPMENT OF SOCIAL INSTITUTIONS AND COMMUNICATIVE PRACTICES
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Виктория Георгиевна Громакова , Елена Александровна Узенцова ,   Технологический институт (филиал)Донского государственного технического университета в г. Азове, Азов, Россия, Ольга Николаевна Шевченко ,   Ростовский государственный медицинский университет, Ростов-на-Дону, Россия
Published: January 2023

The article focuses on the risks of destabilization of social institutions due to the expansion of the digital environment and its penetration into all spheres of society. The main categories of threats arising from the redundancy of information flows, as well as the widespread distribution of content that has disinforming, aggressive, and sometimes clearly extremist content are highlighted. Possible mechanisms of the influence of such Internet practices on the processes of transformation and self-organization in the social system are discussed.
INTERDISCIPLINARITY OF OBJECTIVITY AND METHODOLOGY OF RESEARCH OF POLITICAL ELITES
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Евгений Сергеевич Слива
Published: January 2023

The growth of scientific interest in the study of political elites is accompanied by the expansion of theoretical and methodological discussions. The variety of methodological apparatus and methodological approaches used in elitological research requires a comprehensive analysis. Based on the study of an array of publications, the interdisciplinarity of elitology in general and the phenomenon of political elites in particular is determined. It is shown that the subjectivity of political elites, their properties, development trends are revealed through the application of interdisciplinary methodology. The levels of interdisciplinary methodology are highlighted in order to ensure the completeness and consistency of the study of political elites. The proposed approach can be used to study various aspects of the formation and functioning of political elites.
PROPOSALS FOR OPTIMIZING THE MECHANISM OF EVALUATION MONITORING OF THE ACTIVITIES OF LOCAL SELF-GOVERNMENT BODIES BY REGIONAL AUTHORITIES: ORGANIZATIONAL ASPECT
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Владимир Антонович Сологуб , Алексей Сергеевич Куреневский ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

State policy and the state as a whole can be built in different ways, relying on different methods, functions and management style, but they all have the same basis - they were all formed by consolidating local communities, creating a request from the bottom up to protect the property and rights of each individual representative of these communities. So, within the framework of this study, the main idea is to analyze the methodologies of foreign and domestic evaluation of the effectiveness of local self-government bodies as a grassroots level of government, from which management begins, which best knows and understands the needs of the population and can respond to them, and, as a result, the formation of a different, more perfect and effective from the point of view of organizational and process aspect of the monitoring system.
PREPARATION OF PROPOSALS FOR THE INTRODUCTION OF PROMISING INFO-COMMUNICATION CUSTOMER SERVICES IN THE REPRESENTATION OF STATE AND MUNICIPAL SERVICES IN THE ROSTOV REGION: COMPARATIVE ANALYSIS OF THE BEST EXPERIENCE OF THE SUBJECTS OF THE RUSSIAN FEDERATION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Светлана Львовна Нужнова , Светлана Львовна Нужнова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: January 2023

The article discusses issues related to the introduction of a new concept of interaction between the state and citizens and business on the basis of omnichannel, proactivity of services within the framework of the policy of digital transformation of all spheres of society. Infocommunication client services are becoming a new stage in the development of the provision of state and municipal services. The purpose of the research is to develop proposals for the development of client services in the Rostov region. For this purpose, a comparative analysis of infocommunication services of the leading regions in this matter was carried out: Moscow, St. Petersburg, the Republic of Tatarstan. It is noted that for the development of such services and their distribution, its own regional portal is needed, despite the fact that the services exist separately from the main platform. Proposals for the creation of infocommunication services in the provision of state and municipal services in the Rostov region have been formulated, and the possibility of their integration into existing regional projects is shown.
Pre-market individual investors’ sentiment and IPO initial performance of the emerging market
Authors: Che-Yahya Norliza , Saleh Siti Shahirah , Md-Elias Nura Lina
Published: January 2023

The volatility of the initial return and trading volume is evident from early observations of the Malaysian initial public offering (IPO) market on the first trading day. Making informed investment decisions is essential for a more accurate assessment of businesses and capital security. Investors should therefore be aware of what influences IPO initial return and trading volume. However, only a few amounts of prior research on the initial return and trading volume on the first trading day of an IPO has focused on the issue of investors’ reaction. Specifically, previous studies have not taken into consideration how individual investors feel about IPO companies as the primary influence. In this study, the sentiment of individual investors is measured using the Google Search Volume Score (GSVS), a practical approximation (Da et al., 2011). This is because most people who use Google to look up information, particularly about recently released equities, are individual investors. Between 2004 and 2020, 271 initial public offerings (IPOs) listed on Bursa Malaysia’s Main Market and Access, Certainty, Efficiency (ACE) Market made up the study sample. This study demonstrated that pre-market investor sentiment significantly and favourably effects IPO initial return and trading volume on the first trading day based on ordinary least square regression (OLS) models.
Switching antifungals drugs within the triazole drug class: a potential treatment approach to drug-related hepatotoxicity
Authors: Silvester Eloise , Plover Christine , Gwee Amanda
Published: January 2023

There are limited data on the best approach to managing azole-induced
hepatotoxicity. One described approach is switching between different
triazole agents to prevent the need for intravenous therapy. This case
series describes the outcomes of this approach in seven children. The
most common azole switch was voriconazole to fluconazole (3/7), followed
by fluconazole to voriconazole (2/7). One child each switched from
voriconazole to itraconazole, and posaconazole to fluconazole. Of the
seven cases, five had Grade 3 liver injury and two had Grade 2 liver
injury. These LFT abnormalities were deemed as ‘possibly’ in four cases,
and ‘probably’ in three cases to be related to the first azole
antifungal as per the Naranjo criteria. All had improvement in their LFT
abnormalities after the switch to an alternative azole antifungal. These
data suggest that switching azole antifungals offers a potential
treatment approach to azole-induced hepatotoxicity.
Gain of regularity for a coupled system of generalized nonlinear Schrödinger equations
Authors: Cortés Mauricio Sepúlveda , Mollisaca Raul Nina , Asem Rodrigo Véjar , Villagran Octavio Vera
Published: January 2023

In this paper we study the smoothness properties of solutions to a
one-dimensional coupled nonlinear Schrödinger system equations that
describes some physical phenomena such as propagation of polarized laser
beams in birefringent Kerr medium in nonlinear optics. We show that the
equations dispersive nature leads to a gain in regularity for the
solution. In particular, if the initial data ( u 0 , v 0 ) possesses
certain regularity and sufficient decay as |
x|→∞ , then the solution ( u( t)
, v( t)) will be smoother than ( u 0 , v 0 ) for 0 ≤
T where T is the existence time of the solution.
Toward High-Efficiency Photovoltaics-Assisted Electrochemical and Photoelectrochemical CO2 Reduction: Strategy and Challenge
Authors: Cho Jin Hyuk , Ma Joonhee , Kim Soo Young
Published: January 2023

The realization of a complete techno-economy through a significant
carbon dioxide (CO2) reduction in the atmosphere has been explored in
various ways. CO2 reduction reactions (CO2RRs) can be induced using
sustainable energy, including electric and solar energy, using systems
such as electrochemical (EC) CO2RR and photoelectrochemical (PEC)
systems. This study summarizes various fabrication strategies for
non-noble metal, copper-based, and metal-organic framework-based
catalysts with excellent FE for target carbon compounds, and for noble
metals with low overvoltages. Even though EC and PEC systems exhibit
high energy-conversion efficiency using excellent catalysts, they are
not completely bias-free operations because they require external power.
Therefore, photovoltaics, which can overcome the limitations of these
systems, have been introduced. The utilization of silicon and perovskite
solar cells for photovaltaics-assisted EC (PV-EC) and
photovaltaics-assisted PEC (PV-PEC) CO2RR systems are cost efficient,
and the III-V semiconductor photoabsorbers achieved high solar-to-carbon
efficiency. This review focuses on all the members composed of PV-EC and
PV-PEC CO2RR systems and then summarizes the special cell
configurations, including the tandem and stacked structures. Moreover,
current problems such as a low energy conversion rate, expensive PV,
theoretical limitations, and scale-up to industrialization are discussed
with the suggested direction.
Morphological examination of hard palate in the Tabby cats
Authors: CAN Mehmet , ERMİŞ Ayşe Gizem
Published: January 2023

The aim of this study was to investigate the morphology of the Tabby cat
hard palate by light and scanning electron microscopy (SEM), in addition
to gross and morphometric analysis. A total of 20 Tabby cat heads used.
The materials was provided from the Balıkesir Metropolitan Municipality
Street Animals Temporary Nursing Home and Rehabilitation Center,
Balıkesir, Turkey. Adult, regardless of gender difference, died from
variety of reasons and 20 Tabby cat cadavers which weigh approximately
3-4 kilograms were brought to the laboratory in accordance with the
procedure. Hard palates were subjected to gross examination,
morphometric analysis, light and scanning electron microscopy. The tabby
cats hard palate was split up rostral and caudal parts and incisive
papilla (papilla incisiva), rugae palatina (palatine rugae) and with
gutter between them, the presence of palatine raphe (raphe palatina) and
secondary (palatine rugae) rugae palatina were observed. The rostral and
caudal parts of hard palate were determined to have a smooth appearance
with SEMx540 50 μm magnification and the presence of epithelial
desquamations was found.out. It was determined that rostral and caudal
part of the tabby cat’s hard palate had a honeycomb appearance of the
microplicae of the x6000 5 μm magnification hard palate epithelium with
SEM. Round islets were detected with the SEM at the magnification of
x600 50μm of the incisive papilla, the x270 100 μm of the rostral-caudal
parts, and the x440 50 μm of the gutter between the palatine rugae.
These adaptations of the Tabby cat’s hard palate might increase its
efficiency during ingestion and mastication of hard food and in
directing the food backwards. The study shows the detailed anatomical
description of the hard palate of the Tabby cat with light and scanning
electron microscopy.
Characterization of Obesity-associated Long Noncoding RNAs in Lung
Authors: Fu Xiaoying , Huang Qinmiao , Lin Yancheng , Ling Lin , Ho Kuoting
Published: January 2023

Obesity often increases the risk of cancer and worsens the prognosis.
Unlike most types of cancer, several studies concluded that obesity had
an inverse influence on LUAD survival. Increasing evidence showed that
obesity-related and adipocyte-derived lncRNAs were associated with
cancer initiation, progression, drug resistance, and the tumor
microenvironment in lung cancer. In the present study, we identified two
BMI-associated lncRNAs (LINC01500 and lnc-MAFB-1) that could potentially
regulate tumor progression in LUAD. Both lncRNAs downregulated
significantly in the obese lung. The increased expression level of
LINC01500 could be observed in LUAD tumors and predict poorer survival.
In addition, through estimation from bulk RNA-seq and profiling in
single-cell sequencing, we found that the expressions of both
BMI-associated lncRNAs were associated with macrophages. The
downregulation of BMI-associated lncRNAs could create a less
immunosuppressive microenvironment, leading to a more efficient response
toward immunotherapy. To our knowledge, this is the first study to
investigate BMI-associated lncRNAs in lung. We believe our findings can
expand the understanding of obesity and the immune microenvironment in
lung cancer.
Features and significance of the recent enormous COVID-19 epidemic in China
Authors: Chen Ji-Ming , Gong Huan-Yu , Chen Rui-Xu , Liu Si-Tong , Sun Ming-Hui , Li Guo-Hui , Yang Ting-Ting , Chen Ji-Wang
Published: January 2023

1. A survey on the recent COVID-19 epidemic in China was conducted. 2.
The epidemic likely made over 85% of people in China sick in December
2022. 3. The epidemic likely ended in early January 2023. 4. The
epidemic had the features of spreading more rapidly and widely and
having a higher symptomatic rate than previously thought. 5. The above
features could lead to many severe cases and deaths due to the shortages
of medical resources. 6. The above features greatly enhanced the
population immunity in China, which will accelerate the end of the
COVID-19 pandemic and reduce the emergence of risky variants of
SARS-CoV-2 in China.
Calibration of an expeditious terramechanics model using a higher-fidelity model, Bayesian inference, and a virtual bevameter test
Authors: Negrut Dan , Hu Wei , Li Pei , Unjhawala Huzaifa Mustafa , Serban Radu
Published: January 2023

The soil contact model (SCM) is widely used in practice for off-road
wheeled vehicle mobility studies when simulation speed is important and
highly accurate results are not a main concern. In practice, the SCM
parameters are obtained via a bevameter test, which requires a complex
apparatus and experimental procedure. Here, we advance the idea of
running a virtual bevameter test using a high-fidelity terramechanics
simulation. The latter employs the “continuous representation model”
(CRM), which regards the deformable terrain as an elasto-plastic
continuum that is spatially discretized using the smoothed particle
hydrodynamics (SPH) method. The approach embraced is as follows: a
virtual bevameter test is run in simulation using CRM terrain to
generate “ground truth” data; in a Bayesian framework, this data is
subsequently used to calibrate the SCM terrain. We show that (i) the
resulting SCM terrain, while leading to fast terramechanics simulations,
serves as a good proxy for the more complex CRM terrain; and (ii) the
SCM-over-CRM simulation speedup is roughly one order of magnitude. These
conclusions are reached in conjunction with two tests: a single wheel
test, and a full rover simulation. The SCM and CRM simulations are run
in an open-source software called Chrono. The calibration is performed
using PyMC, which is a Python package that interactively communicates
with Chrono to calibrate SCM. The models and scripts used in this
contribution are available as open source for unfettered use and
distribution in a public repository.
The application of carbon dots in tumor immunotherapy: researches and prospects
Authors: Bi Hong , Cai Hao , Abbas Khurram , Yang Yuxiang , Li Zijian
Published: January 2023

Since the rapid development of nanomedicine in oncotherapy, multiple
nanomaterials are adopted to regulate the immune system in cancer
individuals. Tumor immunotherapy enhances the immune function of
patients to achieve the purpose of killing tumor cells by utilizing the
organism immune mechanism. As emerging inorganic carbon nanoparticles,
carbon dots (CDs) have been found as photosensitizers, vaccines,
immunoadjuvants, and so on for cancer treatment due to their unique
structure and property, such as effective platforms for drug delivery,
immunomodulation, and phototherapy. In this review, we mainly discuss
the recent application of CDs in tumor immunotherapy and the prospects
of CDs in the field of immune medicine. By assessing the achievements
and challenges of CDs in tumor immunotherapy, our review would provide
mechanistic insights into the evolution of future nanomedicine.
Converter Transformer Winding Mechanical Condition Detection Using Online Vibration Frequency Response Analysis Method
Authors: Wu Shuyu
Published: January 2023

The harmonic current and vibration of the converter transformer are
effective information for detecting winding mechanical faults. This
paper proposes an online vibration frequency response analysis (VFRA)
method and constructs a novel vibration frequency response function
(VFRF), where the VFRF is defined as the ratio of vibration acceleration
to current squared. A harmonic loading system simulating the actual
operating situation of the converter transformer is established, and it
is verified by numerical analysis and experimental methods that online
VFRA is a simpler and more convenient method for winding mechanical
condition detection than offline VFRA. The effects of different factors
such as current magnitude and harmonic content on the online VFRA are
investigated, and the converter transformer winding mechanical condition
is detected by combining the VFRF trace with two numerical indices of
relative factor and improved expectation. Laboratory experiments
demonstrate that the online VFRA has high stability and successfully
identify winding looseness faults of different degrees. Compared with
the traditional frequency response analysis (FRA) and short-circuit
impedance (SCI) methods, the online VFRA has higher sensitivity and
detection capability for winding mechanical faults, and is a better
method for online monitoring of winding mechanical condition.
Fabrication of oxygen carrying microparticles functionalized with liver ECM-proteins to improve phenotypic three-dimensional in vitro liver assembly, function, and responses
Authors: Leipzig Nic , Mansouri Mona , W.D Imes , O.S Roberts
Published: January 2023

Oxygen and extracellular matrix (ECM)-derived biopolymers play vital
roles in regulating many cellular functions in both the healthy and
diseased liver. This study reveals the importance of synergistically
tuning the internal microenvironment to enhance oxygen availability
alongside phenotypic ECM ligand presentation to promote native metabolic
functions of human liver three-dimensional (3D) cell aggregates. First,
fluorinated (PFC) chitosan microparticles (MPs) were generated with a
microfluidic chip, then their oxygen transport properties were studied
using a custom ruthenium-based oxygen sensing approach. Next, to allow
for integrin engagements the surfaces of these MPs were functionalized
using liver ECM proteins including fibronectin, laminin-111,
laminin-511, and laminin-521. These MPs were used to assemble
heterogeneous composite spheroids composed of human hepatocytes and
human hepatic stellate cells. After in vitro culture,
liver-specific functions and cell adhesion patterns were compared
between groups and cells showed enhanced liver phenotypic responses in
response to laminin-511 and 521 as evidenced via enhanced E-cadherin and
vinculin expression as well as albumin and urea secretion. Furthermore,
hepatocytes and stellate cells arranged in more phenotypic arrangements
when cocultured with laminin-511 and 521 modified MPs providing clear
evidence that specific ECM proteins have distinctive roles in the
phenotypic regulation of liver cells in engineering 3D spheroids. This
study advances efforts to create more physiologically relevant organ
models allowing for well-defined conditions and phenotypic cell
signaling which together improve the relevance of 3D spheroid and
organoid models.
Trajectory tracking control based on prescribed performance and fractional-order state observer for unmanned helicopters with unmeasurable states
Authors: Shao Shuyi , Wang Liwen , Zhao Qijun , CHEN Hongtian
Published: January 2023

The tracking control problem of trajectory planning is studied in this
paper based on prescribed performance method (PPM) for the small-scale
unmanned autonomous helicopter (UAH) with wind-gust disturbances (WGDs)
and unmeasurable states. For the purpose, the nonlinear model with
flapping dynamics is established, and the transformation performance
function is used to ensure that the errors of trajectory tracking
satisfy the corresponding performance. The fractional-order observers
are investigated to estimate the longitudinal and lateral flapping
angles that are treated as unmeasurable states, and estimate the WGDs,
respectively. Based on PPM and the designed observers, the
fractional-order theory-based backstepping trajectory tracking control
scheme is developed for the UAH system, and the three-dimensional
trajectory is planned by the improved wolf pack algorithm. Then the
stability of the entire system is proven through strict theoretical
analysis. Finally, the simulation analysis on the UAH are presented to
demonstrate the efficiency of the designed method.
Estrategia de comunicación para la salud mental: prevención del suicidio en la comunidad universitaria
Authors: Quintero-Cárdenas Katia Lorena , Herrera-Matías Anyi Tatiana , Mateus-Castiblanco Laura Ximenao , Bernal-Villanueva Zulma Nayiber , Acosta-Sabogal Belky Dayana , Acosta-Agudelo Yalixa , Falla-Bermúdez Tania Valentina
Published: January 2023

Introducción: se estima que cada año 700.000 personas cometen suicidio, es decir, un suicidio cada 40 segundos. Esta es la tercera causa de muerte en los jóvenes entre 20 y 24 años, y representa la tasa más alta de muerte en la región de las Américas en el grupo poblacional entre los 45 y 59 años. Objetivo: orientar hacia la prevención del suicidio a la población en general de la Universidad de los Llanos en Villavicencio, Meta. Materiales y métodos: intervenciones colectivas con base en el contenido temático del curso virtual Prevención de la autolesión y el suicidio: empoderamiento de los profesionales de atención primaria de salud, del Campus Virtual de Salud Pública de la Organización Panamericana de la Salud. Resultados: participaron 74 personas, a las que se les aplicó una encuesta pre y pos intervenciones, en la que se encontró que el 62 % reconoció los factores de riesgo frente al suicidio, el 55 % los síntomas frecuentes, el 61 % las señales de alerta y el 76,2 % aprendió estrategias de prevención. Conclusiones: el predominio de participación de adolescentes interesados en la prevención del suicidio supone la necesidad de más estudios de esta índole en espacios académicos o universitarios.
Can the Novel Coronavirus be found in the Ocular Tissues and Secretions? An Opinion
Authors: AV Prabhu
Published: January 2023

The novel coronavirus outbreak has reached pandemic proportions in a short time, like other respiratory viruses. Respiratory droplets transmit the virus; various body fluids and secretions such as nasopharyngeal swabs, stool, digestive tract, urine, saliva; few anecdotal reports indicate that the virus may be present in ocular secretions and possibilities of transmission by the lacrimal-pump mechanism through tears, thus posing a transmission risk. An exposed ocular surface acts as a gateway for various respiratory viruses. Looking at the nasolacrimal system anatomical and physiological aspects, it bridges the eye and respiratory tissues. Moreover, it can also share some common viral binding receptors. The eye is less frequently involved in SARS-CoV, and conjunctivitis is the only reported complication so far. The positivity of CoV RNA in conjunctival swabs tested by RT-PCR assay in confirmed SARS-CoV patients is low. The ocular route of coronavirus transmission and its detection in the ocular secretions is still controversial. In this narrative analysis, we reviewed the latest literature and explored an in-depth understanding of the ocular consequences of coronaviruses recorded up to now. The search took place for the corresponding journal through the use of the PubMed, PubMed Central (PMC), Daily situations reports, IPC (Invention Prevention Control) guidelines, WHO (World health organization), and from other Internet Sources. To avoid community transmission risk, the general public must also take precautionary measures in relation to the pandemic COVID-19.
Pattern of Eye Diseases in Dhaka City District Level and Village Areas in Bangladesh
Authors: Z Jabbar
Published: January 2023

Background: Ocular morbid conditions are responsible for partial or total blindness. Ocular morbidities by its sheer magnitude form an enormous problem, not only in human suffering, but also in terms of economic loss and social burden. Objective: The aim of this study is to determine the pattern of eye Diseases. Methods: This was a cross sectional study. This study was done in Dhaka city, different districts of Dhaka Division and different Upazilla of Dhaka district. From these three sites 3124 patients were randomly selected. All the members of a family were cross-examined and then diseased individuals were isolated for detail history taking and clinical assessment. Results: The results revealed that 3124 study subjects were had ocular morbidity. Common ocular morbidity was 1153 had Refractive error (36.9%), 105 had Cataract, 15(0.5) had Glaucoma, 63(2.0) had Chronic Dacryocystitis, 14(0.4) had Pterygium, 6(0.2) had Diabetic Retinopathy, 56(0.2) had Retinitis pigmentosa and 1763 (56.4) others. Males were more affected as compared to females. It was observed that as the age increases the prevalence of ocular morbidity increases. Conclusion: The leading cause of eye diseases in this study was Refractive error, Cataract, Glaucoma, Chronic Dacryocystitis, Pterygium, Diabetic Retinopathy, Retinitis pigmentosa and others etc.
Visual Status among Nepalese Civilian Pilots
Authors: Sanjeev Bhattarai
Published: January 2023

Introduction: Vision assessment is a part of medical examination for pilots. Visual acuity and refraction are performed routinely but binocular vision assessment is rarely performed. The aim of this study was to evaluate the visual status of Nepalese civilian pilots, including binocular vision assessment. Methods: It was a descriptive, cross sectional study conducted among Nepalese pilots. Thirty pilots operating domestic flights and twenty operating international flights, from 7 different airline companies participated in this study. A detailed ophthalmic examination of the pilots was performed by an investigator under the guidance of an Optometrist from January to August 2006. Examinations were conducted at Nepal Airlines Corporation, head office and domestic terminal at Tribhuwan international airport (TIA). The data collected were analyzed to determine presenting visual acuity, refractive error and binocular vision of pilots. Results: Among 50 pilots, 88% of pilots had presenting visual acuity within normal limits (6/6 binocularly) as normal requirement set by Civil Aviation Authority of Nepal (CAAN). Pilots having significant refractive errors were 32%. Other visual symptoms related were present in 16% of pilots. Only one case had intermittent exotropia (IXT) and exophoria was present in 15 (30%) pilots among which 3 (6%) had deviation between 4-8 prism diopters. Conclusion: About 90% of Nepalese civilian pilots had normal visual acuity as defined by civil aviation authority of Nepal (CAAN). However, few pilots had some form of binocular vision disorders which could easily be im3proved by vision therapy.
Penggunaan media flashcard pada pembelajaran kosakata bahasa inggris di sekolah dasar
Authors:   Program Studi Pendidikan Guru Sekolah Dasar, Universitas Pendidikan Indonesia Indonesia, Hamidah Nisa , Saputra Erwin Rahayu ,   Program Studi Pendidikan Guru Sekolah Dasar, Universitas Pendidikan Indonesia Indonesia, Indihadi Dian ,   Program Studi Pendidikan Guru Sekolah Dasar, Universitas Pendidikan Indonesia Indonesia
Published: January 2023

English as an international language has an important role in communication in the international sphere. This research is motivated by the lack of motivation to learn English in elementary school students and the difficulty of learning English vocabulary. The purpose of this study is to describe the use of flashcard media in learning English vocabulary. In this study, a qualitative descriptive method was used with a sample of 28 students at Public Elementary School 3 Banjarwangi, Garut, West Java. Data collection was carried out using observation techniques, interviews, and a literature review. From this research, data was generated that the use of flashcard media in learning professional vocabulary could increase students' motivation to learn and improve their understanding of professional vocabulary material. Nonetheless, learning motivation and increased understanding of English vocabulary needs to be in line with interesting and effective learning strategies. Keyword: flashcards, vocabulary, English language, Elementary school