bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil clínico-epidemiológico de pacientes com Paralisia Cerebral assistidos pelo serviço de ortopedia pediátrica de um hospital de referência na região Norte do Brasil
Authors: Assunção Ruan Rotondano , Ribeiro Tiago de Aguiar Andrade , Nunes Giovanna Gilioli da Costa , Souza Isabela de Nazaré Tavares Cardoso , Lucena Caio César Chaves de , Miranda Edson Gabriel Rodrigues , Cecim Paulo Eugênio Santos , Brito João Amaury Francês
Published: December 2024

Objetivo: Descrever o perfil clínico e epidemiológico de pacientes com paralisia cerebral espástica assistidos pelo serviço de ortopedia pediátrica em hospital de referência no Norte do Brasil. Métodos: Trata-se de um estudo de caráter observacional, retrospectivo, transversal, descritivo e analítico, no qual serão analisados os prontuários dos pacientes, em busca da associação entre o perfil epidemiológico e os casos de paralisia cerebral. Resultados: Foram incluídos 103 pacientes diagnosticados com paralisia cerebral espástica, a maioria dos pacientes eram do sexo masculino (60,2%), idade média de aproximadamente 9 anos. Cerca de 32% dos pacientes conseguem se comunicar verbalmente, mas com dificuldade, e 38,8% não conseguem deambular, e necessita do uso exclusivo de cadeira de rodas. A maioria das mães tiveram um pré-natal adequado (64,1%), porém a maior parte das crianças nasceram pré-termo (57,3%), o que justifica as principais intercorrências associadas a PC no presente estudo: prematuridade, hipóxia e anóxia fetal. 83,5% dos pacientes usam a Toxina Botulínica tipo A (TBA), e os membros inferiores são os mais acometidos. Conclusão: Ao final do estudo, conclui-se que o cuidado se inicia antes do período gestacional e se estende aos cuidados específicos pós diagnósticos, e quando feito de forma precoce, os déficits são atenuados.
Oil and gas perspective of the eastern border of the Siberian platform based on recent exploration data
Authors: Pogodaev A. V. , Sevostianova R. F. , Sleptsova M. I. , Zharkov A. M. , Pavlova K. A.
Published: December 2024

As a result of a thorough analysis of geophysics data and deep drilling, it was established that the most likely zones for the discovery of new oil and gas reserves are localized in the north and center of the Pre-Verkhoyansk trough, as well as in the southeastern part of the Siberian platform along the Aldan-Maya trough. The high content of hydrocarbons in the formation waters of productive layers indicates large-scale processes of gas formation and active vertical and horizontal migration, which contributes to the creation of a favorable environment for the formation of free gas. Particular attention is drawn to deposits in Jurassic deposits, formed due to the secondary capture of gas ﬂows during intense vertical and inter-reservoir movement. The key reservoirs for future discoveries are the sandy-clayey Permian deposits under the clayey strata of the Lower Triassic Nedzhelin Formation. Most proven gas reserves are associated with large, high-amputation swell-like uplifts. Modern geological structures and the hydrodynamic potential of the region determine optimal conditions for the migration of hydrocarbons. It is proposed to designate the Kitchanskaya, Yakutskaya and Munskaya zones of expected oil and gas accumulation as priority objects in the central part of the Pre-Verkhoyansk trough and adjacent territories of the Vilyui syneclise. The article examines the oil and gas potential prospects of the Aldan-Maya trough. Here, buried landforms play a key role in geological structures and determine the prospects for the generation and migration routes of hydrocarbons, in the structure of lithological-stratigraphic traps. The industrial signiﬁcance of deposits contained in Riphean sediments has been conﬁrmed in adjacent territories, in particular within the Berezovskaya depression.
Taiga landscapes of the Maya River basin
Authors: Gerasimova D. I. , Zakharov M. I. , Golovanov A. O.
Published: December 2024

The paper contains the results of the study for taiga landscapes in the Maya River basin, obtained during ﬁeld surveys, by describing facies, and using cartographic materials. For the ﬁrst time a map on landscape facies of the Maya River basin was compiled. As a result, a landscape map of the Maya River basin was compiled with the allocation of 10 mapped landscape units by combinations of plant association groups. A map of landscape facies was drawn up for the key site of the Krestyakh area and facies in the vicinity of the Ust-Yudoma settlement were described. The ecological framework of the study area is deﬁned by typical medium taiga larch shrub-greenmoss forests. The Maya River basin is characterised by a high resource signiﬁcance of the valley-river part of the basin geosystem, which experiences a high anthropogenic load. The obtained materials may become the basis for more detailed landscape analysis of taiga geosystems of Central Yakutia and the foothills of the Dzhugdzhur Ridge, for planning decisions on territorial development.
Иноконфессиональные музыкальные цитаты в литургических и светских жанрах второй половины XVI — первой половины XIX в. и Credo Мессы h-moll И. С. Баха
Authors: Денисов А.В.
Published: December 2024

Исследование иноконфессиональных музыкальных цитат связано с решением ряда вопросов, среди которых на первом плане оказываются религиозно-этический и эстетический. Отдельно следует учитывать функциональный аспект: в ка ком контексте автор предполагал исполнение подобных сочинений. Показана историческая изменчивость обращения композиторов к иноконфессиональным цитатам: в XIX в. они все чаще стали возникать в светских жанрах (на первом месте — хорал “Dies Irae”). На конкретных примерах проанализированы причины, объясняющие их появление: внешние обстоятельства (заказ) — “Lauda Sion” Ф. Мендельсона; сочувственное / толерантное отношение автора к другой религии — “Veni Domine” Б. Гуаюля; решение определенных художественных задач — «Гугеноты» Дж. Мейербера; интерес к различным художественным / культовым традициям — фантазии на темы псалмов гугенотов Э. дю Корруа, ряд псалмов из “Estro poetico-armonico” Б. Марчелло, “Dixit Dominus” Г. Генделя; функционирование музыкального материала в «чужой» литургической практике — Траурный антем памяти королевы Каролины Г. Генделя. У композиторов, связанных с немецкой культурой, цитаты выполняли риторические функции; особое положение в этом плане занимает Credo из Мессы h-moll И. С. Баха. В статье рассматриваются первоисточник использованных в нем цитат, особенности их трактовки, а также соотношение с религиозной и художественной концепцией Мессы.

The study of interconfessional musical quotations is linked to the resolution of a number of questions, the most important of which are religious-ethical and aesthetic. The functional aspect should be considered separately: in what context did the author intend such works to be performed? The historical variability of composers’ recourse to interconfes sional quotations is shown: in the 19th century they began to appear more frequently in secu lar genres (first and foremost the chorale Dies Irae). Various examples are analysed to explain the reasons for the appearance of interconfessional quotations: external circum stances — Lauda Sion by F. Mendelssohn; sympathetic/tolerant attitude of the author towards another religion — Veni Domine by B. Hoyoul; solution of specific artistic tasks (for example, the depiction of another confession in the opera) — The Huguenots by G. Meyerbeer; interest in various artistic / cultic traditions — fantasies on the themes of Huguenot psalms by E. du Caurroy, a number of psalms from Estro poetico-armonico by B. Marcello, Dixit Dominus by G. Handel; functioning of musical material in foreign liturgical practice — Funeral Anthem in Memory of Queen Caroline by G. Handel. At the same time, for composers associated with German culture, quotations fulfilled rhetorical functions; the Credo from the Mass h-moll by J. S. Bach occupies a special place in this respect. The primary source of the quotations used in it, the peculiarities of their interpretation in the Mass and their correlation with its religious and artistic concept are examined.
Teachers’ Attitudes Towards AI Integration in Foreign Language Learning: Supporting Differentiated Instruction and Flipped Classroom
Authors: Christina Rapti , Panagiotidis P.
Published: December 2024

The use of Artificial Intelligence (AI) in education is rapidly gaining traction as research in technology has produced a growing number of cutting-edge applications. Indeed, the latest possibilities presented by AI require innovative and alternative methodological approaches to be integrated into the learning process. Within the educational community, and especially among foreign language educators, there is a clear desire and interest in adopting these new tools to enhance and maximise learning outcomes. However, there is also some scepticism regarding potential issues that may arise from their introduction into the learning process. This study presents a survey that examines the utilization of AI by 116 foreign language educators as well as their attitudes towards the utilization of AI in the context of the Greek public and private primary and secondary educational system. The research also explores how differentiated instruction and flipped classroom models can be enhanced by AI. Data was collected through an online survey on Facebook using a structured questionnaire, designed to capture quantitative insights into educators’ AI attitudes. Findings showed that teachers have adopted a positive attitude towards incorporating AI in teaching foreign languages. Indeed, a considerable number of educators employ AI as part of their curriculum, utilizing it also as a means for facilitating differentiated instruction where each student is taught according to his unique abilities and needs. Factors such as age, years of teaching experience and familiarity with AI technologies played a crucial role in shaping teachers’ attitude toward AI. However, the study revealed that one area that has been largely overlooked by researchers is how artificial intelligence could be utilised within flipped classroom settings; this lack of investigation into pedagogical applications represents a significant gap within current knowledge about AI in education thus necessitating further training and support on AI applications to language education.
Perception and preferences of the doctors from the Health Centers towards the use of antibiotics in Prishtina, Kosovo
Authors: Degjoni Rudina , Haxhiu Leunora Brika , Jaha Rabishe Kurti
Published: December 2024

Background: Resistance to antibiotics is a global public health problem with economic, social and political implications, especially in underdeveloped countries. Over the last few years, this challenge has been of particular importance at the global level seriously endangering the effective treatment of many diseases. Purpose: The purpose of this study is to assess the level of use of antibiotics and practices followed by Pristina primary doctors in Kosovo and to educate and educate as many as possible the population of Pristina regarding the use of antibiotics in order to ensure the quality of their lives. Method: A survey was conducted with a random sampling, attended by about 120 doctors of KPSH to indicate whether they have antibiotics with whom they are familiar, as well as antibiotic access and preference, which is the same regardless of the type of specialization staff at the KPSH. Participants were recruited into one of the 12 Main Family Medicine Centers (KPSH) in Prishtina for the period June - July - August 2017. Results: Of the 120 doctors surveyed at KPSH, on the question of whether you have antibiotics with whom you are familiar with, more than half (55%) do not have any favorite antibiotics, while 40% of them have some antibiotics with whom they are familiar. Though 6 (8.1%) of family doctors have reported that they are familiar with many of the antibiotics, there is no significant difference between Chi-square = 4.76; Df = 4; p = 0.313 after testing. About a quarter of the respondents describe antibiotics without antibiograms, and over half of them sometimes and only 10.8% do not prescribe antibiotics without antibiograms, regardless of the type of specialization of staff at SPC. Patient advise on side effects has been performed by most doctors of SCC and only 5 doctors or 4.2% do not give advice to their patients for side effects, but without significant difference depending on the type of specialization. Over 80% of respondents in their daily practice have encountered a known case of resistance to any antibiotic, but without significant difference depending on the type of specialization
Violation of the International Legal Framework on Rescue at Sea
Authors: Elezi Alketa
Published: December 2024

The irregular migration routes are largely organized by smuggling and trafficking networks. Taking advantage of international obligations and human rights law, these criminalized networks have become innovative and strategic. The Central Mediterranean Sea is infamously connoted with the irregular migration phenomenon travelling in irregular means in overcrowded unseaworthy vessels often resulting in fatalities of deaths at sea. The smugglers’ innovative strategy is to first cross the irregular migrants’ boats from the territorial sea of Libya and then leave them stranded at sea, waiting to be rescued by Member States patrol boats or private vessels. Once stranded at sea for days or weeks, the irregular migrants have suffered from starvation, dehydration, suffocation and even violence from human smugglers. In accordance with the international legal framework on Search and Rescue (SAR), captains of vessels have the obligation to rescue them. This research argues that Italy has adopted a new irregular migrant containment strategy in the form of SAR activity discouragement. Their objective is to disengage these smuggling and trafficking networks. To discourage the irregular migrant crossing, the Italian strategy is to prevent and thus stop captains of private vessels or SAR NGOs from responding to rescue calls at sea through criminalizing SAR operations without prior authorization of the disembarking coastal state.. This paper argues that the criminalization measures against captains of vessels is argued to violate the international legal framework on search and rescue, international obligations and international human rights law. This research analysis how border enforcement measures and closed border policies under the pretense of the pandemic have negatively impacted upon the rights of refugees and asylum seekers travelling in an irregular manner by sea.
High Intensity Lipid Lowering Drugs Further Than Statins
Authors:   School of Life Sciences, Devi Ahilya Vishwavidyalya, Takshila Campus, Khandwa Road, Indore-452001 (M.P.), India, A Vyas , K Hajela ,   School of Life Sciences, Devi Ahilya Vishwavidyalya, Takshila Campus, Khandwa Road, Indore-452001 (M.P.), India
Published: December 2024

Lipid-lowering therapies are crucial in reducing the risk of Atherosclerotic Cardiovascular Disease (ASCVD), and statins are the primary drugs used for this purpose. However, statins come with some side effects such as muscle symptoms, liver dysfunction, renal insufficiency, eye conditions, and an increased risk of Type 2 diabetes mellitus. The risk of developing Type 2 diabetes mellitus is dependent on the dose and duration of statin use. Long-term use of statins (= 5 years) has been associated with a significant increase in the risk of diabetes. In this review, we will discuss several new therapies for lipid-lowering, including Ezetimibe, Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors, Bempedoic acid, Lomitapide, Pemafibrate, and angiopoietin-like 3 inhibitor Evinacumab. In addition to durgs, there are several plant-based agents and dietary strategies such as plant sterols, soluble and dietary fiber, nuts, red yeast rice, and a plant-based diet that have shown promise in reducing cholesterol levels. Furthermore, supplementation with Bergamot has also shown benefits in managing cardio-metabolic risk in dyslipidemic subjects. These natural compounds and dietary approaches offer a complementary and natural way to manage cholesterol levels. It’s important to note that while these agents can contribute to lowering cholesterol levels, they are not meant to replace prescribed medications for individuals with high cholesterol.
Linking CD spectra to solution conformational dynamics in miRNA via an integrated experimental and computational approach
Authors: Michaelis Monika , Santos-Carballal Beatriz , Thiessen Laura , Delle Piane Massimo , Colombi Ciacchi Lucio
Published: December 2024

Understanding the structural dynamics of RNA is essential for deciphering its biological functions and advancing the design of RNA-based therapeutics. MicroRNAs (miRNAs), such as hsa-miR-145, present unique challenges due to their conformational heterogeneity and dynamic behavior in solution. Here, we introduce a data-driven approach combining synchrotron CD spectroscopy, enhanced sampling simulations, and computational CD spectra calculations to elucidate the structural dynamics of the hsa-miR-145 duplex and its single-stranded components. By leveraging thousands of computed spectra and structural conformers, we apply an unsupervised classification framework that systematically maps conformational states to their spectroscopic features. Experiments reveal that the duplex adopts an A-form RNA helical structure with a cooperative melting transition, while the single strands remain highly disordered. Clustering methods, based on spectral similarity and eRMSD metrics, identify structural motifs such as hybridization, mismatches, and non-canonical interactions, uncovering the relationships between RNA conformations and CD signal variations. This integration of experimental and computational methodologies highlights the power of data-driven strategies to analyze high-dimensional structural and spectral datasets, offering a pathway for understanding RNA dynamics and guiding the rational design of RNA-based therapeutics.
Precision labeling of proteins in live cells illustrated by in-cell 19F-NMR spectroscopy
Authors: Su Xun-Cheng , Guo Shu-Li , Zhang Xing , Li Bin , Cui Chao-Yu , Li Mo-Han , Pan Bin-Bin , Zhao Jia-Long
Published: December 2024

Deciphering protein activity in living cells, especially at atomic resolution, remains a challenge. Nuclear magnetic resonance (NMR) spectroscopy is a unique tool to provide atomic-resolution information of proteins in live cells, but most currently modification methods for proteins are not suitable for in-cell NMR. Here we introduce a new strategy for site-precise labeling of proteins via a reversible Michael addition reaction-triggered neighbor group participation (RAT-NGP), where the NGP reaction stabilizes the reversible Michael addition product. The RAT-NGP labeling shows high performance in precision labeling of two engineered solvent-exposed cysteines without perturbations on the native cysteines in the target proteins. This labeling strategy causes no significant structural perturbations in the target proteins as examined by NMR and CD spectroscopy. In-cell 19F NMR shows that the RAT-NGP labeling method enables site-precise labeling of target proteins in live cells and effectively avoids the over consumption and interference of intracellular glutathione (GSH).
Targeting SARS-CoV-2 Main Protease Variants: Investigating the Role of the P132H Mutation in Ligand Binding and the Potential of Withania somnifera Phytochemicals
Authors: Mishra Vibha , Malik Divya , Agrawal Shivangi , Bhavya Bhavya , Pathak Ekta , Mishra Rajeev
Published: December 2024

Mutations in viral proteins, especially at allosteric sites, can profoundly influence therapeutic strategies by altering protein dynamics, stability, and ligand interactions. This study investigates how the P132H mutation in SARS-CoV-2 Main protease (Mpro), an allosteric mutation distal to the catalytic pocket, reshapes the protein’s dynamics and ligand-binding properties. Our findings provide compelling evidence that such allosteric mutations can introduce structural plasticity, altering therapeutic responses and posing both challenges and opportunities for drug design. Phytoconstituents from Withania somnifera emerge as promising candidates, with compounds like Coagulin Q and Withanolide J showing potential to exploit allosteric changes for effective inhibition. By unraveling the interplay between allosteric regulation and protein-ligand dynamics, our work offers an effective framework for understanding mutation-driven structural adaptations in viral proteins. Here, the binding dynamics of Withania somnifera phytoconstituents with both wild-type (WT) and P132H mutant (MT) Mpro was explored using molecular docking, 10.2 µs MD simulations, MM-GBSA energy decomposition, PCA, DCCM analysis, Global Community Analysis, residue-residue interaction network analysis and solvent-accessible surface area (SASA) analysis. The potential of phytoconstituents from Withania somnifera as antiviral agents offers promising avenues for therapeutic development against SARS-CoV-2 variants and other rapidly evolving pathogens. This study emphasizes the importance of integrating allosteric mechanisms into antiviral design strategies, presenting insights that could inform the development of therapeutics against not only SARS-CoV-2 but also other rapidly mutating pathogens.
Cloud Synthesis: A Global Close-Loop Feedback Powered by Autonomous AI-Driven Catalyst Design Agent
Authors: Zhang Di , Jia Xue , Liu Heng , Wang Yuhang , Ye Songbo , Jiang Qiuling , Wang Yuan , Zhang Linda , Wei Li , Yang Weijie , Xu Haoxiang , Cheng Daojian , Hashimoto Yusuke , Tomai Takaaki , Li Hao
Published: December 2024

The Digital Catalysis Platform (DigCat) pioneers a revolutionary framework for cloud-based synthesis and global closed-loop feedback, redefining catalyst research through advanced automation and collaboration. By integrating >400,000 experimental and >400,000 structural data points with cutting-edge AI tools, DigCat streamlines catalyst discovery and optimization into a seamless, automatic, and data-driven workflow. Through its five-step process—ranging from material design to pH-dependent microkinetic modeling—the platform delivers unparalleled accuracy and efficiency. Accessible globally via the cloud, DigCat enables researchers worldwide to leverage its robust computational capabilities, driving the development of next-generation catalysts with enhanced stability and performance.
Advancing Multiscale Molecular Modeling with Machine Learning-Derived Electrostatics
Authors: Semelak Jonathan A. , Ignacio Pickering , Huddleston Kate K. , Olmos Justo , Grassano Juan S , Clemente Camila , Drusin Salvador I. , Marti Marcelo , Gonzalez Lebrero Mariano C. , Roitberg Adrian E. , Estrin Dario A.
Published: December 2024

We introduce an innovative machine learning (ML)-based framework for multiscale molecular modeling, in which the ML subsystem is treated as an electrostatic entity interacting with its molecular mechanics (MM) environment through classical electrostatics. The integration of ML accuracy with multiscale modeling is accomplished by leveraging the capabilities of the ANI neural networks to predict geometry-dependent atomic partial charges at the Minimal Basis Iterative Stockholder (MBIS) level, going beyond static mechanical embedding. This ML/MM approach can closely approximate state-of-the-art multi-scale quantum-classical (QM/MM) methods while significantly lowering computational requirements, thereby facilitating more efficient and precise simulations in computational chemistry. The method requires no additional training beyond the initial model setup and is integrated into Amber, one of the most widely used software suites for molecular modeling, ensuring accessibility to the broader community. We validate its performance across a variety of challenging applications, including solvation structure, vibrational spectra, torsion free energy profiles, and protein-ligand interactions, achieving excellent agreement with QM/MM benchmarks. This framework not only advances the frontiers of multiscale modeling but also showcases the potential of machine learning to achieve quantum-level accuracy with exceptional efficiency for complex chemical systems.
Capturing the sol and gel states of thermoresponsive polyoxazoline / -oxazine hydrogels by ambient and subambient solid-state NMR
Authors: Zorn Theresa , Bachmann Stephanie , Polzin Lando , Greiner Johannes , Luxenhofer Robert , Pöppler Ann-Christin
Published: December 2024

Recently it was shown that ABA-type triblock copolymers with pPheOzi as central B-block undergo a cooling induced order-order transition from spherical to worm-like micelles accompanied by inverse thermogelation. Previous attempts to modulate the chemical structure of the pPheOzi block prevented worm-formation or even thermogelation. Here, two novel polymer variants were synthesized bearing -CH3 or -OCH3 at the para-position of the phenyl group of pMeOx-b-pPheOzi-b-pMeOx. Rheological, µDSC and AFM analyses proved thermogelation and formation of worm-like micelles of pMeOx-b-pMeOPheOzi-b-pMeOx, while pMeOx-b-pMePheOzi-b-pMeOx remains a sol of spherical micelles. In order to understand the macroscopic phenomena at the molecular level, a detailed NMR study has been carried out. NMR spectroscopy in solution was used to visualize the subset of mobile polymer moieties in the corona, whereas rigid moieties were analysed in-detail by solid-state NMR. Intermediate motions can interfere with classical solid-state NMR analyses, but freezing the samples successfully improved the visibility of moieties in this dynamic regime. Combining solid-state NMR of frozen samples with DSC revealed three types of water —non-freezable bound, freezable-bound, and free water— with indications for water also being present in the core of micelles and worms. Based on the complementary insights due to the additional frozen sol- and gel-state NMR experiments, the -OCH3 within the B-block could also be identified to stabilize the core-water interaction leading to prolonged thermal stability for the new pMeOx-b-pMeOPheOzi-b-pMeOx gels.
Enhanced Charge Transport Through Ion Networks in Highly Concentrated LiSCN-polyethylene Carbonate Solid Polymer Electrolytes
Authors: Kumbhakar Kajal , Palchowdhury Sourav , Pham Thuy Duong , Shin Seoeun , Chun So Yeon , Shim Joong Won , Lee Kyung-Koo , Cho Minhaeng , Kwak Kyungwon
Published: December 2024

Challenging the preference for bulky anions due to low binding energy with Li+ ion, the lithium thiocyanate-polyethylene carbonate (LiSCN-PEC) solid polymer electrolyte (SPE) demonstrates higher ionic conductivities (3.16x10-5 S cm-1) at polymer-in-salt concentration (100 mol%) compared to those with lithium bis(fluorosulfonyl)imide (LiFSI, 1.01x10-5 S cm-1) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, 1.72x10-7 S cm-1). Through the careful selection of PEC and LiSCN as components of SPE, the carbonyl stretching of PEC and the SCN⁻ stretching band as vibrational reporters provide detailed structural insights into the Li⁺ ion transport channel. Spectroscopic investigations reveal that enhanced ion aggregation alters the solvation structure around the Li+ and diminishes the interaction between Li+ and polymer (PEC) with increasing LiSCN concentrations, promoting faster segmental motion as a major transport mechanism. However, the transition observed from subionic to superionic behaviour in the Walden plot indicates the onset of segmental motion decoupled charge transport pathway. The SCN- vibrational spectrum elucidates the evolution from a Li--SCN--Li type chain-like structure to a Li2>SCN
Research on Digital Virtual Human Head Avatar Generation Technology with Cartoon Style
Authors:   School of Information Engineering, Guangzhou Vocational College of Technology & Business, Guangzhou 511442, China, Xiao Bin
Published: December 2024

This paper proposes a Generative Adversarial Network (GAN)-based approach for generating anime-style cartoon avatars, addressing the current limitations in cartoon avatar datasets, including their scarcity and copyright restrictions. Due to the limited availability of high-quality, diverse cartoon datasets, particularly for anime-style faces, obtaining large-scale labeled data for training deep learning models remains a significant challenge. To overcome these issues, we train a GAN model on a large collection of anime-style images to generate unique, high-quality cartoon faces. The generator learns to capture the distinctive features of anime art, such as exaggerated expressions, vibrant colors, and stylized facial proportions, while the discriminator ensures the realism and diversity of the generated avatars. Our experimental results demonstrate that the proposed method not only produces visually appealing avatars faithful to the anime aesthetic but also offers a scalable solution to the datasets limitations and copyright concerns. This approach opens up new possibilities for applications in digital art, gaming, and social media, where custom cartoon avatars are increasingly in demand.
Los videojuegos en el aprovechamiento educacional en estudiantes de cuarto año de EGB, de una institución de Ecuador, 2024
Authors: Carvajal Morales Jessica Mariela , Criollo Turusina Milton Alfonso , Ron Vargas María Elena
Published: December 2024

El fin del estudio es determinar la incidencia de los videojuegos en el aprovechamiento educacional en los estudiantes de cuarto de EGB de una institución de Ecuador durante el año 2024, empleando una metodología cuantitativa básica, no experimental descriptiva. La población fue conformada por la totalidad de estudiantes de cuarto año de una institución educativa situándose en una muestra de 30, tomada por el muestreo no probabilístico por conveniencia, del mismo modo, se empleó la encuesta mediante el uso de un cuestionario compuesto por 24 preguntas cerradas. Estas preguntas permitieron recopilar datos relevantes sobre el aprovechamiento educacional de los estudiantes y su posible incidencia relacionada con la utilización de videojuegos. También, se llevó a cabo una exhaustiva revisión bibliográfica que incluyó la búsqueda de artículos, libros y revistas científicas que aborden la problemática en aras del objeto de estudio. En base a los resultados mostraron que el 40.14% de los educandos muestra un nivel alto de interés en los videojuegos que a su vez promueve el desarrollo personal y social denotando que el conocimiento y comprensión del mundo influye en la percepción de la realidad, es decir; el rendimiento académico está influenciado altamente con el entorno en dichos estudiantes, mientras que, el 41.67% se sitúa en nivel medio de influencia, y el 18.19% muestra nivel bajo. De esta manera se concluye que los videojuegos y el rendimiento académico proporcionan experiencias, resuelven problemas, y desarrollan habilidades prácticas. Esto a su vez contribuye al conocimiento autónomo y al desempeño académico.
Towards a Ribā-Free Pakistan: 26th Constitutional Amendment and the Way-Forward
Authors: Jamil Syed Hassan
Published: December 2024

The elimination of ribā (interest) has been a longstanding aspiration of the people of
Pakistan. This goal is rooted in the nation's desire to align its financial system with Islamic
principles. Earlier, Article 38 (f) of the Constitution provided a policy principle to
“eliminate Riba as early possible”. However, the interest-free system could not be adopted
despite the passage of 50 years. While the Federal Shariat Court (FSC) reiterated in its
judgment of February 2022 that interest is ribā and must be eliminated from the economy
th by December, 2027, 26 amendment provided a clear timeline mandating the State of
Pakistan to eliminate the ribā from the country by January 01, 2028. This landmark
amendment in the Constitution requires the government and the regulators of banking and
nonbanking business and finance institutions to take urgent and well-thought-out steps for
the transition of the economy to ribā-free bases.
Impact of Islamic and Conventional Microfinance on Poverty Alleviation: A Comparative Study
Authors: Asif Nadeem Muhammad , Akhter Waheed , Akhtar Sherani Muhammad
Published: December 2024

Purpose: This study investigates the impact of microfinance on poverty alleviation and compares the effects of both Islamic and conventional microfinance for poverty alleviation. Design/Methodology/Approach: This cross-sectional research has adopted a quantitative research design, and a survey research strategy has been used for collecting data from microfinance clients. The data are analyzed through SPSS and AMOS software. Findings: Both Islamic and conventional microfinance are found to be helpful in poverty alleviation, wherein Islamic microfinance is found to be more suitable for poverty alleviation than the conventional microfinance. Originality/Significance: This study represents the initial attempt to comprehensively compare the efficacy of Islamic and conventional microfinance in alleviating poverty, based on the available knowledge. Additionally, it emphasizes the significant impact of Islamic microfinance on poverty alleviation. Research Limitations/Implications: This study provides useful implications to policymakers and practitioners for improving microfinance strategies aiming to fulfill the objective of poverty alleviation. Further, it provides policy recommendations for microfinance institutions, donors in the microfinance sector, and the government.
O ENSINO DE QUÍMICA NA PERSPECTIVA CTS ARTICULADO COM AS INFLUÊNCIAS FREIREANAS
Authors: Oliveira Ana Laura dos Santos , Ferreira Francisca Rayssa Freitas , Vasconcelos Ana Karine Portela
Published: December 2024

O Ensino de Ciências no Brasil, mais especificamente o Ensino de Química, é muito marcado pela cultura de planejar aulas pautadas em conceitos e conteúdos. Uma possibilidade de se modificar isso, seria através das influências do movimento Ciência, Tecnologia e Sociedade (CTS) trazendo um novo olhar para os currículos de ensino de Química, utilizando um outro tipo de abordagem, a Abordagem Temática (AT), balizada nas ideias de Paulo Freire. Realizou-se então, uma Revisão Sistemática da Literatura (RSL) de natureza qualitativa descritiva com o objetivo de tecer reflexões sobre como a Abordagem Temática de Paulo Freire aliada ao Enfoque CTS pode favorecer o Ensino de Ciências e o Ensino de Química. A RSL foi dividida em três fases: Planejamento, Execução e Análise dos Resultados, que serão detalhadas na metodologia. A busca foi realizada em três bases de dados: Scientific Electronic Library Online (SciELO), Scopus e CAPES. Após a triagem, formou-se um compilado de 10 artigos que foram revisados seguindo duas categorias: A construção de um currículo pautado na Abordagem Temática e a Formação de Professores numa perspectiva humanística e crítica. Podemos perceber nos artigos revisados, que a Abordagem Temática, articulada com o enfoque CTS viabilizam o desenvolvimento de temas de relevância social, em uma perspectiva crítica e transformadora.
ESTRATÉGIAS PARA ENSINO DA MATEMÁTICA NA EDUCAÇÃO INFANTIL V
Authors: Paiva Ana Angélica Nunes , Becker-Ritt Arlete Beatriz
Published: December 2024

A Educação Infantil, conforme a Base Nacional Comum Curricular (BNCC), deve respeitar dois eixos estruturantes: interações e brincadeiras. Abordar conceitos matemáticos, nesse nível de ensino, mostra que é preciso buscar estratégias para direcionar o trabalho dos professores, principalmente, no que diz respeito à aprendizagem mais significativa e contextualizada. Este estudo compreende as estratégias para o ensino da matemática na Educação Infantil V e apresenta uma proposta para este de forma mais atrativa e clara para crianças do Ensino Básico. Foi aplicada e analisada uma estratégia para a aprendizagem dos conceitos de quantidade na Educação Infantil, utilizando a modelagem matemática, envolvendo brincadeiras com massa de modelar. Trata-se de uma pesquisa qualitativa que, para coleta de dados, lançou mão de pesquisas documental, bibliográfica e participativa. A partir de uma sequência didática para a Educação Infantil, elaborada com massa de modelar e relacionando conceitos matemáticos, os dados foram coletados. Apontamentos no diário de campo também auxiliaram a análise dos resultados. A pesquisa foi realizada em uma escola municipal de Fortaleza, no Ceará, com estudantes de uma turma do Ensino Infantil V. Concluiu-se que a matemática desempenha um papel fundamental no desenvolvimento das crianças, quando ensinada de maneira apropriada. Ao longo desta pesquisa, constatou-se a importância de abordagens que buscam superar possíveis resistências ao aprendizado dessa disciplina, as quais podem prejudicar, significativamente, o desempenho acadêmico das crianças. Diante disso, espera-se oportunizar ampliação de saberes discente, desde a educação infantil, preparando esse sujeito para o protagonismo crítico, autônomo e letrado no mundo da matemática.
PRÁTICA DE ASSESSORAMENTO PEDAGÓGICO EM TECNOLOGIA EDUCACIONAL EM PROGRAMAS DE FORMAÇÃO CONTINUADA DE PROFESSORES DA EDUCAÇÃO BÁSICA
Authors: Câmara Aldemira de Araújo , Azevedo Rosa Oliveira Marins
Published: December 2024

Este estudo tem como objetivo apresentar um panorama das produções acadêmicas que tratam a respeito do assessoramento pedagógico em tecnologia educacional em programas de formação continuada de professores da educação básica.  Foi realizada uma Revisão Integrativa (RI), em dissertações e teses disponíveis no portal da CAPES e BDTD, sem período definido, por meio de um protocolo com base em Mendes e Pereira (2020), em quatro etapas:  I – Objetivo e pergunta; II – Busca dos trabalhos; III – Seleção dos trabalhos; e IV – Análise dos trabalhos selecionados.  A partir de critérios qualitativos, os trabalhos selecionados foram analisados na perspectiva da Espiral de Creswell (2014), sendo evidenciadas quatro categorias: 1) O assessoramento pedagógico em tecnologia educacional como espaço de formação mútua proporciona a troca de experiências e a partilha de saberes; 2) O Assessoramento Pedagógico em tecnologia educacional como etapa de um programa de formação continuada de professores orienta o planejamento e a implementação de projetos no contexto escolar; 3) O assessoramento pedagógico em tecnologia educacional é importante na criação de redes de formação de professores para compartilhamento de experiências; e 4) O assessoramento pedagógico em tecnologia educacional contribui com a formação continuada e prática pedagógica de professores. Os resultados indicaram a importância da prática de assessoramento pedagógico em tecnologia educacional como estratégia formativa, alinhada às ações dos programas de formação continuada de professores da educação básica, para inserção das Tecnologias Digitais da Informação e Comunicação (TDICs) na prática pedagógica do professor com intencionalidade pedagógica.
ENSINO DE BOTÂNICA: PRODUÇÃO NA PÓS-GRADUAÇÃO DO NORTE DO BRASIL
Authors: Magalhães Thales Pessoa , Martins Aurinéia Claudio , Teles Nayana Cristina Gomes
Published: December 2024

O ensino de Botânica tem sido visto como desinteressante pelos estudantes, potencializando um fenômeno chamado “cegueira botânica”. Posto isto, o presente estudo realizou uma revisão sistemática de dissertações e teses defendidas entre 2002 e 2022 em Instituições de Ensino Superior da região Norte utilizando a base de dados da Biblioteca Digital Brasileira de Teses e Dissertações. Com base em dois descritores, “Ensino de Botânica” e “Ensino de Botânica na Amazônia”, buscou-se identificar a expressividade das pesquisas na região e compreender quais estados mais contribuíram com pesquisas, possibilitando a percepção dos grupos vegetais mais favorecidos nesses estudos. Foram encontradas 12 dissertações, representando 5,5% da produção nacional, apontando para o desinteresse em compreender o ensino de Botânica na região amazônica.
METODOLOGIAS ATIVAS NO ENSINO DE CIÊNCIAS: OS DESAFIOS DA PRÁTICA NA PERSPECTIVA DOCENTE
Authors: Pepino Lorena Vargas Soares , Mackedanz Luiz Fernando
Published: December 2024

As metodologias ativas de ensino são estratégias pedagógicas cujo objetivo central é promover o protagonismo dos estudantes no processo de aprendizagem. No contexto do ensino de Ciências, essas metodologias são promissoras, pois contribuem para uma formação integral e científica dos estudantes. No entanto, apesar de suas contribuições, a aplicação das metodologias ativas não está isenta de desafios. Diante disso, este artigo faz parte de uma investigação realizada em uma dissertação de mestrado no Programa de Pós-Graduação em Educação em Ciências na Universidade Federal do Rio Grande. O objetivo deste trabalho é apresentar e discutir os desafios associados à utilização de metodologias ativas no ensino de Ciências, a partir da perspectiva dos professores de Ciências dos Anos Finais do Ensino Fundamental da rede municipal de ensino do Rio Grande. Para a coleta de dados, foram utilizados questionários e entrevistas, envolvendo a participação de 29 professores de Ciências. A análise de dados foi conduzida utilizando a metodologia da Análise Temática e revelou uma série de obstáculos em relação à aplicação de metodologias ativas, tais como a falta de motivação dos estudantes, conhecimento dos professores e limitações de tempo e recursos. Portanto, apesar do potencial enriquecedor das metodologias ativas para o ensino de Ciências, sua implementação requer conhecimento e adaptação dos professores para superar os desafios da prática, os quais podem ser abordados a partir de diferentes perspectivas formativas e pedagógicas.
The Role of Perceived Social Support on Loneliness in Predicting the Level of Depression in Social Media Users
Authors: Octaviane Rita , Roswiyani Roswiyani
Published: December 2024

Prolonged social media use can increase loneliness and potentially affect mental health, including depression. This study explored the effect of perceived social support on loneliness in predicting depression in 134 early adult social media users (18-34 years old) who used social media more than 3 hours per day and experienced mild depression (PHQ-9). Instruments included the UCLA Loneliness Scale version 3, MSPSS, and BDI-II. Regression analysis with moderation showed that perceived social support did not significantly moderate the relationship between loneliness and depression (p > 0.05). However, social support from family had a significant direct effect in reducing depression (p < 0.05), while the dimensions of friends and significant others were not significant. These results indicate that although perceived social support is not strong enough as a moderator in the loneliness-depression relationship, the family dimension still plays an important role directly in reducing depression. The direct results indicate a direct contribution to depression through the family dimension. Thus, although perceived social support as a whole does not moderate this relationship, certain dimensions still have a direct effect.
Keywords: Depression; Early adulthood; Loneliness; Social media; Social support
The Role of Self-Concept and Self-Compassion on the Body Image Adolescent Fans of K-Pop Idols
Authors: Parasari Anak Agung Istri Miranda , Suarya Luh Made Karisma Sukmayanti
Published: December 2024

Adolescent of K-Pop fans tend to set the appearance of K-Pop idols as the ideal body standard, thus potentially causing body dissatisfaction and forming a negative body image. The aim of this research is to be able to find out the role of self-concept and self-compassion with the body image adolescent fans of Korean Pop (K-Pop) idols through a quantitative approach with multiple linear regression analysis. The research respondents were 131 adolescent K-Pop fans aged 15-22 years in the city of Denpasar. The research results show that self-concept and self-compassion together contribute to five dimensions of body image (appearance evaluation (R2=49,1%), appearance orientation (R2=18,7%), body area satisfaction (R2=32,1%), overweight occupation (R2=8,9%), and self-classified weight (R2=40,5%)). Self-concept partially contributes in appearance evaluation, appearance orientation, body area satisfaction, and self-classified weight, while self-compassion contributes to overweight occupation (p<0,05). This study underscores the significance of cultivating a positive self-concept and self-compassion as an effort for adolescent of K-Pop fans to be aware, accept their body condition, and start taking care of themselves to get a healthy body.
Keywords: Adolescent, Body Image; K-Pop; Self-compassion; Self-concept
Analysis of Determinants of Exclusive Breastfeeding in Breastfeeding Mothers
Authors: Purwaningsih Dewi , Sudarmi Sudarmi
Published: December 2024

Exclusive breastfeeding for babies aged 0-6 months, which continues until the age of 2 years accompanied by adequate complementary feeding, has an essential meaning, especially regarding the fulfillment of nutritional needs and other substances to form the body's immunity to disease, because at that age the baby's condition is still precarious. This study uses an analytic survey research cross-sectional design. The aim was to analyze the relationship between determinants of exclusive breastfeeding. The population of all mothers with babies aged 6-12 months amounted to 127, using a purposive random sampling technique. Sample calculation, according to Slovin, obtained a sample of 84. Data collection using a questionnaire. Univariate analysis with percentages, bivariate analysis with chi-square test. There is a relationship between knowledge (p-value=0.026), Early initiation breastfeeding (EIBF) history (p-value=0.005), breastfeeding self-efficacy (p-value=0.042), breastfeeding motivation (p-value=0.016), cultural customs (p-value=0.012), and family support (p-value=0.036) with exclusive breastfeeding in mothers who have babies aged 6-12 months at the Tanjung Sari Health Center, South Lampung Regency in 2024. A relationship exists between breastfeeding self-efficacy knowledge, motivation, and exclusive breastfeeding. There is a relationship between breastfeeding self-efficacy knowledge, breastfeeding motivation, cultural customs, and family support with exclusive breastfeeding. Suggested improving IEC (Communication, Information, and Education), implementing lactation management programs, making behavioral changes, and providing support for exclusive breastfeeding.
The Impact of Internet Finance and Diversified Financing Models on the Development of the Sports Industry
Authors: Che Yijiahui
Published: December 2024

With the growth of the sports industry, the demand for financing has been increasing, while traditional financing channels are facing limitations. The emergence of Internet finance has provided new opportunities for the sports sector. This paper focuses on the diversified financing pathways for the sports industry, supported by internet finance, exploring its impact through theoretical analysis, constructing a regression model for empirical research, and conducting case analysis. The study finds that the development scale of Internet finance and the crowdfunding financing model significantly influence the income of the sports industry. Accordingly, the paper offers relevant policy and application suggestions, aiming to provide a reference for optimizing financing within the sports industry through Internet finance.