bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploitation of Advanced Deep Learning Methods and Feature Modeling for Air Quality Prediction
Authors: Parthiban ShreeNandhini , Amudha Palaniswamy , Sivakumari Subramaniam Pillai
Published: January 2023

Air pollution is a major issue because Particulate Matter (PM) has a substantially higher effect on human health than other pollutants. Air Quality (AQ) prediction has become critical recently to take action to reduce pollution. This research introduces a unique methodology for assessing the effectiveness of PM10 and PM2.5. Enhanced spatial, temporal sequence-Improved Sparse Auto Encoder with Deep Learning (EISAE-DL) has been proposed to predict AQ affected by the prolonged dependency of air pollution congregation. However, Long Short-Term Memory (LSTM) used in EISAE-DL has suffered from the learning of a long-term dependent sequence of the training dataset. In addition, it is hard to create very reliable AQ forecasts at higher periodic frequencies, such as daily, weekly, or even monthly. This paper proposes Transfer learning (TL) in a Stacked Bidirectional and Unidirectional LSTM to solve the learning issue in LSTM for long-term dependencies. So, EISAE-DL with TL and modified LSTM model is named as EISAE-Deep Transfer Learning (EISAE-DTL). TL with a modified structure can handle large-size datasets effectively. However, training time is increased more than twice for non-transfer learning way of modeling due to TL, Wasserstein Distance-based adversarial learning is proposed in EISAE-DTL to decrease the variances among AQ data collected from any two sites. The proposed work is named EISAE- Enhanced DTL (EISAE-EDTL). The developed EISAE-DTL and EISAE-EDTL models are compared and analyzed with the performance of existing algorithms EISAE-DL, ISAE-DL, TL-BLSTM, MMSL, and ST-DNN. The experimental findings demonstrate the accuracy, precision, sensitivity, specificity, Area Under Curve (AUC), and Matthew's correlation coefficient of the proposed model performs admirably and improves present condition approaches.
Monitoramento de Abelhas Africanizadas (Apis mellifera L.) usando tecnologia de rádio frequência (RFID) em Belém, Pará
Authors: Pereira Daniel Santiago , Oliveira Marcos Enê Chaves , Moura Max Jorge , Carvalho Welton de Andrade de , Arruda Helder Moreira , Costa Luciano , Deus Jessyca Camilly Silva de , Medeiros Aline Carla de , Silva Rosilene Agra da , Maracajá Patrício Borges , Holanda-Neto João Paulo de , Said Paulo , Xavier Carlos Fernandes , Carvalho Cláudio José Reis de , Fonseca Vera Lúcia Imperatriz , Souza Júnior Paulo Antônio de
Published: January 2023

Este trabalho objetivou acompanhar o comportamento das abelhas africanizadas (Apis mellifera L.), utilizando sensores de rádio frequência – RFID em Belém, Pará, Brasil. A metodologia empregada baseou-se na fixação de rastreadores às abelhas, passando a ser observadas por ondas eletromagnéticas, por meio de um condutor de metal ou carbono que funciona com antena, trocando informações com o sistema através de seus EPCs (Eletronic Product Code). A avaliação comportamental dessas abelhas com o uso da tecnologia RFID poderá trazer informações de grande importância para um melhor entendimento da biologia comportamental do inseto e suas relações com o bioma amazônico, as quais também poderão ser utilizadas na potencialização da polinização e da produção de mel para a geração de renda aos apicultores da região da Amazônia Oriental.
Psychometric assessment of the Persian version of the patient determined disease steps scale in patients with multiple sclerosis and neuromyelitis optica spectrum disorder
Authors: Mirmosayyeb Omid , Shaygannejad Vahid , Afsharzadeh Mahshad , Bataei Roozbeh , Nehzat Nasim , Mohammadi Aida , Ghajarzadeh Mahsa
Published: January 2023

Background: The purpose of this study was to evaluate the validity and reliability of the Persian version of Patient Determined Disease Steps (PDDS) in both patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD).
Methods: One hundred and forty-five patients were enrolled between May and September 2020 by consecutive sampling. Participants were asked to complete timed 25-foot walk (T25FW), 12-item Multiple Sclerosis Walking Scale (MSWS-12), and Multiple Sclerosis Quality of Life-54 (MSQOL-54). Patients also completed Timed Up and Go (TUG) and six-minute walk (6MW) tests. Construct validity was assessed by calculating correlation between PDDS and ambulatory and demographic items. The intra-class correlation coefficient (ICC) was used to evaluate reliability.
Results: One hundred and eleven patients with MS and 34 with NMOSD with disease duration of 7.6 ± 5.8 years were enrolled. Twenty-seven percent were men and mean Expanded Disability Status Scale (EDSS) was 1.8 ± 1.8. evident in MS subgroups and NMOSD [secondary progressive MS (SPMS): rho = 0.64, P < 0.001; relapsing-remitting MS (RRMS): rho = 0.47, P < 0.001; NMOSD: rho = 0.52, P = 0.001]. PDDS had also significant positive correlation with TUG, T25FW, and MSWS-12. PDDS had also significant negative correlation with 6MW test. PDDS had weak correlation with demographic variables. The ICC was calculated as 0.99 for PDDS.
Conclusion: The Persian version of PDDS provides valid and reliable instrument to assess MS/NMOSD-related disability.
Assessment of COVID-19 vaccine attitude in people with multiple sclerosis, its correlation with demographic factors, and fear of coronavirus: A cross-sectional survey
Authors: Fattahi Mohammad Reza , Iranmehr Arad , Saeedi Roghayyeh , Sahraian Mohammad Ali , Doosti Rozita , Moghadasi Abdorreza Naser
Published: January 2023

Background: Despite special global considerations which have been made to prioritize vaccination of people with multiple sclerosis (MS), some are reluctant to get vaccinated. This study was aimed to evaluate the attitude toward coronavirus disease-2019 (COVID-19) vaccine and its probable correlations.
Methods: Considering the study objectives, two valid questionnaires including Fear of COVID-19 Scale (FCV-19S) and attitude questionnaires were administered pre and post COVID-19 vaccination among people with MS.
Results: The questionnaires were administered among 349 people with MS pre and post vaccination. The mean age of participants was 38.78 ± 8.68 (range: 19 to 64) years. They all received the first dose of COVID-19 vaccine (Sinopharm). Although about 90% of participants felt satisfied after getting vaccinated and respected the preventive actions like social distancing and wearing face mask after vaccination, about 40% of them did not recommend vaccination to other patients. None of the demographic data was predictor of attitude score in COVID-19 vaccine and the only effective factor regarding fear of COVID-19 among people with MS was gender (P = 0.001). the more he/she felt satisfied after vaccination. Those patients who had got the influenza vaccine last year felt more satisfied with the vaccine and accepted the COVID-19 vaccine easier than others.
Conclusion: This study revealed that there was an inverse correlation between fear of coronavirus and less trust in the vaccine in patients with MS. However, it should be mentioned that the patients felt more satisfied after COVID-19 vaccination.
Frequency of Kell and Rh alloantibodies in Iranian Thalassemia Patients in Khorasan Razavi Province, Iran
Authors: Foomani Farzad Mollahoseini , Sadeghian Mohammad Hadi , Bagheri Saeede , Badiee Zahra , Bazargani Reihane , Aryanpour Zahra , Hallajiayan Saeid , Shams Seyyede Fatemeh
Published: January 2023

Background:  Thalassemia is an inheritance disease with anemia and hemolysis. Blood transfusion is a routine treatment for thalassemia patients; alloimmunization is one of the complications of blood transfusion, which is very serious for these patients, especially girls and young women.   
Materials and Methods: In this cross, sectional study 446 thalassemia patients were examined. Demographic information of patients was extracted and recorded. The phenotype of ABO, Rh and Kell antigens (tube method) with antisera from IMMUNDIANOSTICA Company (Germany) and frequency of alloantibodies was determined.
Results: 55.8% of studied individuals were male and 44.2% were female. Mean age of studied patients was 19.94±10.63.  The alloantibodies were detected in 7.5% of pack cell receivers. The most prevalent phenotype of ABO system was O blood group (37.4%), and the most abundant antigen of Rh group was ‘e’, which was found in 99.8% of studied population. The most frequent detected alloantibody was Anti K (38.2%); concerning kell phenotype, (K_k+) and (K+k+) were found in 99.3% and 0.7% of patients, respectively. The frequency of Anti-D, Anti-C, Anti-c and Anti-E was 23.5%, 14.7%, 2.9% and 14.7%, respectively.
Conclusion: According to the results of this paper, finding the compatible pack cells in terms of Kell and Rh systems antigens in addition to ABO blood group is recommended to decrease the rate of alloantibodies in thalassemia patients.
The Involvement of Canonical NFκB Pathway in Megakaryocyte Differentiation Induction by Nanocurcumin
Authors: Mortazavi Farsani Seyedeh Sahar , Sadeghizadeh Dina , Babashah Sadegh , Rad Fariba , Sadeghizadeh Majid
Published: January 2023

Background: Megakaryopoiesis is characterized by progressive polyploidization and the expression of megakaryocytic markers. Numerous transcription factors and physiological signaling pathways regulate this phenomenon. Megakaryocyte differentiation induction in the K562 cell line and hematopoietic stem cells via nanocurcumin drug has been identified in our previous study. K562 cells are typical Chronic Myelogenous Leukemia (CML) cells that are resistant to apoptosis and express the bcr-abl fusion gene. These cells have the potential to differentiate into erythrocytes and megakaryocytes. Curcumin is well known as a component with strong potential to alter NFκB activity in various cells. NFκB pathway regulates various genes such as apoptotic and immune response genes. The aim of the current study is to evaluate the possible role of nanocurcumin in NFκB pathway regulation during the megakaryopoiesis process in the K562 cell line.
Materials and Methods: Megakaryocyte markers expression and phenotype alteration of nanocurcumin-treated K562 cells have been detected by flow cytometry and microscopy imaging. The nuclear level of the RelA (p65) subunit of NFκB was determined by western blot test in K562 cells during megakaryopoiesis induction via nanocurcumin treatment at different times. The expression of NFκB target genes including c-MYC, BAX, and NQO1 was also analyzed in nanocurcumin-treated K562 cells by quantitative RT-PCR assay at different times.
Results: It was demonstrated that nanocurcumin leads to an increase in NFκB activity transiently during megakaryocyte differentiation, which is followed by a change in the expression of c-MYC, BAX, and NQO1 target genes.
Conclusion: The NFκB pathway can be considered a new pathway for inducing megakaryocyte differentiation by nanocurcumin for the purposes of in vitro and in vivo megakaryopoiesis experiments.
The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave
Authors: VURAL Asli , DİKBAS Oguz , VURAL Selahattin , BOZOĞLAN Hümeyra , SÖNMEZ Bircan
Published: January 2023

Objectives: Despite strong evidence regarding the impact of radioactive iodine (RAI) on the hematopoietic, genitourinary, and gastrointestinal systems, its role in the cardiovascular system needs to be clarified. We hypothesized that the presence of a presystolic wave could be predictive for cardiovascular dysfunction in subjects receiving RAI. Thus, we investigated presystolic wave presence in differentiated thyroid cancer (DTC) patients with and without RAI therapy after undergoing total thyroidectomy.
Methods: Patients were included in the study within 1-5 years after thyroidectomy or thyroidectomy and RAI treatment. Participants were divided into three groups as follows: the first group included patients with DTC who received RAI following total thyroidectomy (Group 1; n = 33), the second group included patients with DTC who did not receive RAI following total thyroidectomy (Group 2; n = 34). The third group of age-matched subjects who underwent total thyroidectomy with suspicion of DTC and resulted in benign pathologies was also selected (Group 3; n = 37). All subjects underwent transthoracic echocardiography. The presence of a presystolic wave was assessed with Doppler imaging of the left ventricular outflow tract.
Results: Presystolic wave was more common in subjects receiving RAI (Group 1) compared to Group 2 (those without RAI) (90.9% vs. 61.8% respectively, p = 0.003), and its prevalence in Group 3 was 54.1%. Multiple logistic regression analysis revealed that receiving RAI (OR: 4.922, 95% CI: 1.640 – 20.022, p = 0.004) was independently associated with a 5-fold higher risk for the presence of a presystolic wave.
Conclusions: RAI following total thyroidectomy in patients with DTC is associated with a five-fold increase in the presence of the presystolic wave, as a proxy marker for subclinical left ventricular dysfunction.
Of Monsters, Myths and Marketing: The Case of the Loch Ness Monster
Authors: Moir James
Published: January 2023

This paper examines the status of the Loch Ness Monster within a diverse body of literature relating to Scotland. Within cryptozoology this creature is considered as a source of investigation, something to be taken seriously as a scientific or quasi-scientific object to be studied and known, particularly in light of its elusive nature. In terms of mythology the creature is bound up with Scottish cultural identifications through references to a rugged wilderness landscape and to iconic, if stereotypical, images of tartanry, bygone castles, and folklore. Both sets of ideas have been used with great effect to generate a diversity of literature: from books and scientific papers that chronicle the sightings and “hunt” for the creature as well the possible case for it being a line of long-surviving plesiosaurs, through to children’s literature that deals with the mythic element that is so often used to appeal to childhood imagination, and on to a plethora of tourist marketing booklets and brochures.
Breaking the Hard Limits: Romance, Pornography, and the Question of Genre in the Fifty Shades Trilogy
Authors: McAlister Jodi
Published: January 2023

The Fifty Shades series has brought erotic fiction to a broader and more mainstream audience than ever before. In its wake, a number of erotic romance series have achieved unprecedented popularity, such as Sylvia Day’s Crossfire series and Lisa Renee Jones’ Inside Out series. These books do not fit comfortably into the genres of romance or pornography: rather, they fuse the romantic and pornographic together. This locates the multiple climaxes of pornography within the overarching emotional climax of romance and creates a structure that is both finite and infinite, allowing the books to create both instant and delayed gratification. This article examines The Sheik as a textual forebear to Fifty Shades before moving on to examine the ways in which romance and pornography are fused, overcoming the limits of serialization in romance, and creating a romantic “pornotopia.”
The American Dream and American Greed in Fanny Fern’s Ruth Hall: Sentimental and Satirical Christian Discourse in the Popular Domestic Tale
Authors: Van Nyhuis Alison
Published: January 2023

Although Fanny Fern’s Ruth Hall: A Domestic Tale of the Present Time originally was a widely popular book in the nineteenth century, Fern and Ruth Hall were criticized after readers learned about the similarities among Fern’s life and book. Contemporary critics have recovered Ruth Hall from the literary margins and situated Ruth’s story in the context of the popular American dream story while emphasizing the book’s satirical elements. Reexamining the novel’s originally popular sentimental elements alongside the novel’s more recently popular satirical elements expands the literary critical focus from Ruth’s sentimental struggles and Fern’s satirical accomplishments to Ruth Hall’s equally important critique of American greed, especially among wealthy and socially-conscious Christians.
The Transformational Leadership and School Culture on The Learning Organization Capacity in Vocational Schools
Authors: Masbirorotni Masbirorotni , Pratama Robin , Fajaryani Nunung , Abrar Mukhlash
Published: January 2023

This study aimed to examine the direct and indirect effects of principals' transformational leadership with school culture as a moderator variable on the capacity of learning organizations. By proposing and testing a conceptual model, this study examined the two main variables as determinants of Learning Organization (LO) capacity with the target respondents were teachers in State Vocational High Schools in Jambi City. This study used a quantitative approach with a cross sectional survey design. A total of 599 state vocational high school teachers in Jambi City were involved in this research survey. Of 599 teachers, there were only 365 data acceptable to be analyzed. Partial Least Square – Structural Equational Model (PLS-SEM) was used at the stage of model measurement and hypothesis testing. The study indicated that leadership implementation and school culture that had been applied to increase organizational learning is in progress.
The Prototype of ACCDR Model: M-Learning Multimedia Development Design Model Stem-Based for the Online Science Learning
Authors: Sari Dian Ratna , Muhaimin Muhaimin , Sukmono Tedjo
Published: January 2023

Online learning is learning carried out without face-to-face but supports the development of virtual academic mobility. It can be integrated with multimedia either in e-learning or m-learning. M-learning is a learning paradigm that takes advantage of developments in wireless and mobile technology. It is flexible, independent, and accessible anywhere and anytime. Integration of science and technology in multimedia m-learning becomes more comprehensive when combined with the principles of Science, Technology, Engineering, and Mathematics. STEM-based multimedia m-learning is developed using a specific development design model. The multimedia m-learning development design model is a structured framework or reference for developing multimedia m-learning. Some of the existing m-learning multimedia development design models do not fully cover the criteria for a suitable model for developing STEM-based multimedia m-learning. One solution that can be given is to develop a new model concept using the F2-O1-S1-A2 type model development procedure through literature studies. The instrument consisted of the model development matrices. Afterward, a STEM-based multimedia m-learning development design model for science learning consisted of five syntaxes, namely: analysis, concepting, design, development, and review. The ACDDR model is a linear diagrammatic-narrative procedural model which is then shortened to the ACDDR model and presented in a prototype form. The ACDDR prototype model is expected to be able to be used for the development of STEM-based multimedia m-learning in the 21st century learning.
Afeminados, agresivos y peligrosos sexualmente
Authors: Camino Alejandro
Published: January 2023

A finales del siglo XIX y en las primeras décadas de la centuria siguiente, los sectores anticlericales en España desplegaron un doble discurso sobre los hombres católicos, en especial los eclesiásticos. Les presentaron como personas afeminadas, mansas, cobardes y sumisas y, a la vez, como peligrosas sexualmente (solo en el caso de los eclesiásticos), irracionales y agresivas. A pesar de la apariencia, ambas caracterizaciones no solo no eran contradictorias, sino que eran complementarias. Respondían al objetivo de desvalorizar la figura del hombre católico y de la masculinidad católica y, a la vez, de alertar de sus peligros. La principal preocupación que tenían los sectores anticlericales era que los curas controlasen la voluntad de las mujeres de su familia, pues entendían que, si eso ocurría, lo que estaban haciendo en realidad era poner coto a su autoridad como cabezas de familia.
El Carlismo de base que permaneció en retaguardia y la limpieza política en Navarra en 1936-1937
Authors: Mikelarena Fernando
Published: January 2023

En este artículo se analiza la participación del carlismo de base que permaneció en retaguardia en el proceso de limpieza política registrado en Navarra en 1936-1937. No todos los carlistas marcharían inmediatamente el frente, sino que por medio de diversa documentación (el Fichero de Excombatientes, información de prensa y bibliográfica) se advierte que una parte de ellos permanecería durante días, semanas o meses en los pueblos del sur de la provincia y en Pamplona en labores de control y vigilancia, tomando parte en batidas y formando parte del Tercio Móvil, la unidad represiva requeté. La documentación de la Junta Central Carlista de Guerra de Navarra y los expedientes de depuración del magisterio muestran indicios del trasfondo de su mentalidad represora.
Protestas ecologistas urbanas en la transición española
Authors: Brito Díaz Juan Manuel
Published: January 2023

En este artículo se analizan los impactos políticos de las protestas ecologistas y su relación con los procesos de transformación urbana y cambio político que se produjeron en el final del Franquismo y la Transición. A partir del estudio de caso de Las Palmas de Gran Canaria se caracterizan los principales actores, temas, campañas de movilización y repertorios de protesta ambiental, y se propone una interpretación del papel del asociacionismo ecologista urbano como agente democratizador durante la Transición española.
“Mitigar los males que la revolución en la península había causado en América”
Authors: Rodríguez Tapia Andrea
Published: January 2023

Este artículo analiza el modo en que en 1823 la Regencia y los gobiernos absolutistas retomaron la gestión de los territorios de ultramar. Se indaga en los discursos que responsabilizaban al gobierno constitucional de la pérdida de la América continental, y en las prácticas desplegadas al momento de hacer frente a una nueva realidad americana, donde una cantidad importante de provincias se habían declarado independientes. Se estudian las disposiciones administrativas y de gobierno que ejecutaron tanto la Regencia y el Consejo de Indias, como los ministros del gobierno, particularmente, los oficios de Víctor Damián Sáez. Con lo anterior, este trabajo busca contribuir a la comprensión de la segunda restauración absolutista de Fernando VII y al estudio de la política americana desarrollada por un gobierno que creía contar con el apoyo de las potencias de la Restauración.
Justiça alimentar
Authors: Carvalho Karina de Paula
Published: January 2023

Este trabalho apresenta algumas ideias conceituais para fazer apontamentos que visam auxiliar nos estudos de seus desdobramentos no tempo e no espaço diante de questões contra-hegemônicas que se colocam capazes de contribuir para pensar caminhos de transição justas dos sistemas alimentares e a promoção do Direito Humano à Alimentação Adequada e Saudável. O objetivo é fazer uma reflexão de elementos teóricos que corroboram a ação pública, evidenciando as dimensões da desigualdade, iniquidades e ideais de justiça que fundamentam pensar na ordem dos enquadramentos nos processos de transição, em várias dimensões de determinantes sistêmicos.  A análise teórica recorre a uma leitura da justiça alimentar, por uma perspectiva multiescalar e relacional, ao considerar que os critérios de justiça social e de direitos vêm sendo incorporados nas proposições de transformações nos sistemas alimentares atuais. Os resultados apresentam que o conceito de justiça alimentar, como vem sendo construído, avança ao considerar os entrelaçamentos sistêmicos que promovem desigualdades e iniquidades por incorporar questões para além dos alimentos no socio-espaço.
Erosão e gestão costeira em praias protegidas por recifes no litoral sul de Pernambuco
Authors: Câmara Isaias Farias da , Holanda Tiago Fernando de , Costa Mirella Borba
Published: January 2023

Praias protegidas por recifes estão presentes em grande parte do litoral do nordeste brasileiro. O padrão de alternância entre baías e pontais, típicos dessas regiões, criam condições de peculiaridades no que diz respeito aos processos erosivos. Nesse contexto, este trabalho tem como objetivo avaliar variações espaço-temporal da linha de costa (LC) entre 2003-2020 utilizando o software DSAS como subsídio para o gerenciamento costeiro no município de Tamandaré, sul de Pernambuco. Os resultados encontrados mostram a heterogeneidade da distribuição dos valores de erosão e acreção. O trecho protegido ao sul, controlado pela dinâmica do Rio Mamucabas, apresenta somente taxas de erosão; o trecho exposto (Baía de Tamandaré), apresenta taxas erosivas ao sul e progradantes ao norte, sendo classificada como instável; e o trecho protegido urbanizado apresentou-se como mais heterogêneo, possuindo alternância de taxas de erosão/recuo e acreção/avanço. Neste, as ocupações estão mais densamente presentes e mais próximas da LC, em detrimento das ocupações na baía. O estudo de taxas erosivas anuais e do padrão de ocupação aplicado a legislação vigente são ótimos instrumentos para subsidiar decisões do Poder Público, sobretudo, no que diz respeito a uma boa gestão da zona costeira.
Attitude and acceptance toward COVID-19 vaccines among Kabul city’s residents: A cross sectional study
Authors: SAMADİ Assadullah , ABDALİ Sayed Sharif , SANGARY Mohammad , ALİZADA Mohammad Naiem , NEYAZİ Abdul Jawid , FARAHMAND Mohammad Yosuf
Published: January 2023

Objective: The present study aimed to assess the attitude and perception of Kabul city’s residents toward COVID-19 vaccines hesitancy and acceptance.

Methods: Applying a cross-sectional study design, the data was collected from 665 participants in Kabul city using a predesigned validated questionnaire. For statistical analysis, Spearman correlation, chi-square, and logistic regression techniques were used.

Results: Although the vaccine availability was limited for the public during the survey period, 70.5% of the participants were willing to receive COVID-19 vaccines. Meanwhile, 49.2% participants were concerned about the COVID-19 vaccines side effects. The presence of positive COVID-19 cases among family members and friends (OR: 2.7), presence of fears during COVID-19 pandemic (OR: 4.4) and beliefs that vaccine has important and vital role in people’s protection against COVID-19 (OR: 5.3), increase the likelihood of vaccine acceptance among the participants. On the other hand, participant’s mistrust of the safety of COVID-19 vaccines (OR: 0.21) and disbelief on ministry of public health “MoPH” advice about COVID-19 vaccine safety and efficiency (OR: 0.27) decrease the odds of COVID-19 vaccine acceptance among the respondents. In addition, a strong correlation was found between vaccine attitude and vaccine acceptance scales (Spearman ρ=0.52, p<0.001).

Conclusion: Although majority of the participants were willing to receive the COVID-19 vaccines, due to high level of participant’s concerns about COVID-19 vaccines-related side effects, a great proportion of the respondents were hesitate to receive the COVID-19 vaccines. Accordingly, public awareness about COVID-19 vaccines must be increased to counteract incorrect and misleading propaganda about vaccination and immunization.
Fracture of Be and its Alloys - Webb Space Telescope Revisited
Authors: Rafique Muhammad Musaddique Ali
Published: January 2023

NASA/ESA/CSA joint venture James Webb Space Telescope is about to be launched. It is hypothesized to operate in near-infrared range. It is also hypothesized to unveil early star formation, galaxies, and universe due to its orbit, point in orbit and orbital motion. It has been under manufacturing for over 20 years at a staggering cost of 10 billion US dollars (most expensive scientific experiment in history). Beryllium (Be) is chosen to be element for construction of its main mirrors due to its high stiffness, low density, low linear coefficient of thermal expansion (α) in cryogenics and high thermal conductivity. It is followed by gold (Au) layer deposition on its (Be) surface to enhance its sensitivity towards infrared radiation as later is hypothesized to bear superior properties. However, serious mistakes have been made in selecting this material for this application. Owing to its crystal structure (hexagonal close packed (hcp)), slip planes (basal, prismatic and pyramidal) and mechanisms of their activation, Be necessitates easy fracture at cryogenic temperature. It has anisotropic properties and prone to transverse fracture under tensile loading. Furthermore, its ductile to brittle transition temperature is very low making it entirely unsuitable for such an application. It is one of most expensive metals on planet. This study constitutes revisiting these fundamental properties and mechanisms which were entirely ignored during materials selection thus rendering whole project useless.
A Comparative Analysis of Human Hepatic Lesions in Dengue, Yellow Fever, and Chikungunya: Revisiting Histopathological Changes in the Light of Modern Knowledge of Cell Pathology
Authors: Ribeiro Yasmin , Falcão Luiz Fábio Magno , Smith Vanessa Cavaleiro , Sousa Jorge Rodrigues , Pagliari Carla , Franco Edna Cristina dos Santos , Cruz Ana Cecília Ribeiro , Chiang Jannifer O. , Martins Lívia Caricio , Nunes Juliana Abreu Lima , Vilacoert Felipe Souza da Silva , Santos Lais Carneiro dos , Furlaneto Matheus Perini , Fuzii Hellen Thaís , Bertonsin Filho Marcos Virgilio , Da Costa Luccas Delgado , Duarte Maria Irma Seixas , Furlaneto Ismari Perini , Martins-Filho Arnaldo Jorge , Aarão Tinara , Vasconcelos Pedro F.C. , Quaresma Juarez Antônio Simões
Published: January 2023

Arboviruses such as yellow fever virus (YFV), dengue virus (DENV), and chikungunya virus (CHIKV) presenting wide global dissemination and the pathogenic profile developed in infected individuals, which develop from nonspecific clinical conditions to severe forms, characterized by the promotion of significant lesions in different organs of the harborer, culminating in multiple organ dysfunction. To characterize, quantify, and compare the patterns of histopathological alterations in human liver samples from patients with yellow fever (YF), dengue fever (DF), and chikungunya fever (CF). Analytical cross-sectional study by histopathological analysis with 70 samples of liver patients, collected from 2000 to 2017, with confirmed laboratory diagnosis who died due to infection and complications by the YF, DF, and CF. Of the histopathological findings in human liver samples there was a significant difference between the control and infection groups, with a predominance of alterations in the midzonal area of the three cases analyzed, among the arboviruses studied, the hepatic involvement in cases of YF showed greater intensity of histopathological changes. Among the alterations evaluated, cell swelling, microvesicular steatosis and apoptosis were classified as degree of tissue damage from severe to very severe. The pathological abnormalities associated with infection by YFV, DENV, and CHIKV showed predominance of changes in the midzonal area. We also noted that in among of the arboviruses studied, liver involvement in cases of YFV infection was more intense.
Breaking the Continuity and Uniformity of Cancer In The Worst Case of Full Connections With Extreme Failed SuperHyperClique In Cancer's Recognition Applied in (Neutrosophic) SuperHyperGraphs
Authors: Garrett Henry
Published: January 2023

In this research, assume a SuperHyperGraph. Then a ``Failed SuperHyperClique'' $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum cardinality of a SuperHyperSet $S$ of SuperHyperVertices such that there's a SuperHyperVertex to have a SuperHyperEdge in common. Assume a SuperHyperGraph. Then an ``$\delta-$Failed SuperHyperClique'' is a \underline{maximal} Failed SuperHyperClique of SuperHyperVertices with \underline{maximum} cardinality such that either of the following expressions hold for the (neutrosophic) cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)| > |S\cap (V\setminus N(s))|+\delta,~|S\cap N(s)| < |S\cap (V\setminus N(s))|+\delta.$ The first Expression, holds if $S$ is an ``$\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is an ``$\delta-$SuperHyperDefensive''; a``neutrosophic $\delta-$Failed SuperHyperClique'' is a \underline{maximal} neutrosophic Failed SuperHyperClique of SuperHyperVertices with \underline{maximum} neutrosophic cardinality such that either of the following expressions hold for the neutrosophic cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)|_{neutrosophic} > |S\cap (V\setminus N(s))|_{neutrosophic}+\delta,~ |S\cap N(s)|_{neutrosophic} < |S\cap (V\setminus N(s))|_{neutrosophic}+\delta.$ The first Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperDefensive''. A basic familiarity with Extreme Failed SuperHyperClique theory, Extreme SuperHyperGraphs theory, and Neutrosophic SuperHyperGraphs theory are proposed.
Astrovirology: how viruses will enhance our understanding of life in the universe
Authors: Trubl Gareth , Stedman Kenneth , Bywaters Kathryn , Matula Emily , Sommers Pacifica , Roux Simon , Merino Nancy , Yin John , Kaelber Jason , Avila-Herrera Aram , Johnson Peter , Johnson John , Borges Schuyler , Weber Peter , Pett-Ridge Jennifer , Boston Penelope
Published: January 2023

Viruses are the most numerically abundant biological entities on Earth. As ubiquitous replicators of information molecules and agents of community change, viruses have potent effects on life on Earth and may play a critical role in human spaceflight missions, life detection missions to other planetary bodies, and in planetary protection. However, major knowledge gaps constrain our understanding of the Earth’s virosphere: 1) the role viruses play in biogeochemical cycles, 2) the origin(s) of viruses, and 3) the involvement of viruses in the evolution, distribution, and persistence of life. As viruses are the only replicators that span all known types of nucleic acids, an expanded experimental and theoretical toolbox built for Earth’s viruses will be pivotal for detecting and understanding life on Earth and beyond. Only by filling in these knowledge and technical gaps will we obtain an inclusive assessment of how to distinguish and detect life on other planetary surfaces. Meanwhile, space exploration requires life-support systems for the needs of humans, plants, and their microbial inhabitants. Viral effects on microbes and plants are essential for Earth’s biosphere and human health, but virus-host interactions in spaceflight are poorly understood. Viral relationships with their hosts respond to environmental changes in complex ways which are difficult to predict by extrapolating from Earth-based proxies. These relationships must therefore be studied in space to fully understand how spaceflight will modulate viral impacts on human health and life-support systems, including microbiomes. This review addresses key questions that must be examined to incorporate viruses into Earth system models, life-support systems, and life detection. Further, the results of tackling these questions will help in our efforts to develop planetary protection protocols and further our understanding of viruses in astrobiology.
Neutrosophic Version Of Separates Groups Of Cells In Cancer's Recognition On Neutrosophic SuperHyperGraphs
Authors: Garrett Henry
Published: January 2023

In this research, assume a SuperHyperGraph. Then a neutrosophic SuperHyperMatching $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of high neutrosophic cardinality neutrosophic SuperHyperEdges such that there's no neutrosophic SuperHyperVertex not to in a neutrosophic SuperHyperEdge and there's no neutrosophic SuperHyperEdge to have a neutrosophic SuperHyperVertex in a neutrosophic SuperHyperEdge; a neutrosophic SuperHyperMatching SuperHyperPolynomial $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the neutrosophic SuperHyperPolynomial contains the neutrosophic coefficients defined as the neutrosophic number of the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of high neutrosophic cardinality neutrosophic SuperHyperEdges such that there's no neutrosophic SuperHyperVertex not to in a neutrosophic SuperHyperEdge and there's no neutrosophic SuperHyperEdge to have a neutrosophic SuperHyperVertex in a neutrosophic SuperHyperEdge and the neutrosophic power is neutrosophicly corresponded to its neutrosophic coefficient; a neutrosophic R-SuperHyperMatching $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of high neutrosophic cardinality neutrosophic SuperHyperVertices such that there's no neutrosophic SuperHyperVertex not to in a neutrosophic SuperHyperEdge and there's no neutrosophic SuperHyperEdge to have a neutrosophic SuperHyperVertex in a neutrosophic SuperHyperEdge; a neutrosophic R-SuperHyperMatching SuperHyperPolynomial $\mathcal{C}(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the neutrosophic SuperHyperPolynomial contains the neutrosophic coefficients defined as the neutrosophic number of the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of high neutrosophic cardinality neutrosophic SuperHyperVertices such that there's no neutrosophic SuperHyperVertex not to in a neutrosophic SuperHyperEdge and there's no neutrosophic SuperHyperEdge to have a neutrosophic SuperHyperVertex in a neutrosophic SuperHyperEdge and the neutrosophic power is neutrosophicly corresponded to its neutrosophic coefficient. It's useful to define a ``neutrosophic'' version of a SuperHyperMatching . Since there's more ways to get type-results to make a SuperHyperMatching more understandable. For the sake of having neutrosophic SuperHyperMatching, there's a need to ``redefine'' the notion of a ``SuperHyperMatching ''. A basic familiarity with neutrosophic SuperHyperMatching theory, SuperHyperGraphs theory, and neutrosophic SuperHyperGraphs theory are proposed.
The Application of Structural Equation Modeling in Nursing Research: A Bibliometric Analysis
Authors: Yuan Qiuchen , Dai Zhenwei
Published: January 2023

ObjectivesThe present study is aimed at characterizing and identifying the important research trends of the application of structural equation modelling (SEM) in nursing research by bibliometric analysis, and further providing reference for nursing researchers to conduct SEM research.MethodsA descriptive bibliometric analysis of publications in the application of SEM in nursing research. Literatures were retrieved from the Web of Science (WoS) core collection database On April 30, 2022. CiteSpace 6.1.R1 and VOSviewer 16 software were used for visualization and bibliometric analysis.ResultsThe annual publication indicated an increasing trend in the future. The intellectual structures of the application of SEM in nursing researches included patient safety, cross-cultural comparison, compassion fatigue, benchmarking, patient discharge, China, psychometrics, and policy. The hotpots and development trends include job satisfaction, nursing home, and nursing student.ConclusionThe hotspots and development trends related to the application of SEM in nursing research mentioned in this study may be helpful for researchers to explore new directions in this field. The intellectual structures and development trends were found in the application of SEM in nursing researches in this study. The awareness of the clusters and bursts in this field can help nursing researchers avoid overlooking some important issues when conducting SEM, and provide nurse researchers with good practice guidelines for conducting SEM.
Comparison Two Methods between Injection Saline and External Fixator in Rat Tail Disc Degeneration
Authors: Khaleque Md Abdul , Choi Eun-Yong , Kim Young-Yul , Park Sang-Eun , You Hwang-Yong , Lee Woo-Jin
Published: January 2023

Purpose: Intervertebral disc is a leading avascular organ in the body. Hence, it may utilize autophagy and apoptosis to alive in unfavorable condition like stress and mechanical force. But excessive force and stress is a key cause to intervertebral disc degeneration (IVDD). Purpose of this study is to identify, external fixator (EF) and saline injection (SI) may induce autopahgy and apoptosis mediated nucleus pulposus (NP) cells death in rat tail’s disc and which method is better for studying autophagy and apoptosis. Methods: Sixteen 9-week-old male Sprague–Dawley rat tails were treated with 0.9% saline and EF (two-cross kirschner wires) for 6 weeks and 12 weeks as well. Treated discs were dissected for checking out participation of autopahgy and apoptosis to intervertebral disc degradation (IVDD). For identifying them, we performed H&E staining, Masson’s trichrome staining, and Immunohistochemistry (IHC) for LC3, Beclin-1and P62 as well as MMP-2, MMP-3 and TIMP-1.Furthermore, we performed quantitative polymerase chain reaction (qPCR)to check out autophagy related gene expression (beclin-1, LC3 and P62) and apoptosis related gene expression (MMP-2, MMP-3 and TIMP-1) respectively. Results: More insidious nucleus pulposus (NP) cell degeneration was indentified in (EF) group than in (Ctrl) control group. And rate of degradation was elevated with increasing duration of compression, but SI group cannot distinguish the margin of AF and NP cells. Highest along with lateral expression was found for LC3, Beclin-1, and P62 of both groups. Up-regulated and central expression was observed for MMP-2, MMP-3 and TIMP-1 of both groups, although SI group cannot recognize the margin between NP and AF cells. Utmost autophagy related gene expression was identified in EF group than in SI group. Besides, maximum autophagy accumulating materials was found in EF group than in SI group. And it was amplified along with increasing the duration of compression. Highest, apoptotic gene expression was observed in SI group, whereas, EF group showed lowest expression. Conclusion: External fixator (EF) method was better to study autophagy and apoptosis because it enhanced IVDD after compression which is actively linked with autophagy and apoptosis. Degeneration process was conversely proportional along with duration of compression. On contrary, saline injection (SI) could not distinguish AF and NP cell border.
Diagnosis of Labor and Human Evolution: Why Is It so Difficult to Diagnose Labor in Humans?
The Contribution of Metabolomics
Authors: Ragusa Antonio , Matta Maria , Rinaldo Denise , Meloni Alessandra
Published: January 2023

The difficulty in the clinical diagnosis of labor is due to an evolutionary mismatch. The ability to hide the signs and symptoms of labor is an evolutionary trait that was once advantageous, but became maladaptive due to environmental changes. Prospective diagnosis of labor is not possible with certainty using only clinical criteria; however, by analyzing the urinary metabolome of women in labor, this diagnosis is likely possible in all cases. In this review, we explain why the two methods (clinical and metabolomic) differ in efficacy and sensitivity, and we try to fit this difference into an evolutionary framework that explains these discrepancies considering evolutionary mismatch. The study of metabolomics allows the truth to emerge from the past, and the diffusion of metabolomic techniques and their application to clinical reality in the form of POC (Point of Care) could change the management of labor and childbirth in the future.
Rodent Proliferation in Urban and Agricultural Settings of Sub-Saharan Africa – Part 2. Towards Integrated Management Strategies.
Authors: Dalecky Ambroise , Garba Madougou , Ibrahim Danzabarma Abdoul Aziz , Etougbetche Jonas , Badou Sylvestre , Dossou Henri-Joël , Sow Ibrahima , Niang Cheikh Tidiane , Diene Ousmane , Diallo Idrissa , Saghiri Mohamed Seyidna Ali , Sidatt Mohamed El Hady , Van Steenbergen Frank , Bal Amadou Bocar , Bosma Luwieke , Houemenou Gualbert , Ag Atteynine Solimane , Hima Karmadine , Dobigny Gauthier , Meheretu Yonas
Published: January 2023

The use of synthetic chemical rodenticides is the most commonly practiced rodent management method in sub-Saharan Africa which results in health and environmental risks without any significant improvement in terms of reducing rodent pest populations sustainably. In this paper, which is a second part of a diptych, we advocate for better control of the use of synthetic chemical rodenticides in urban and agricultural settings in sub-Saharan Africa, as well as a shift towards more sustainable and environment-friendly rodent management approaches, such as the Ecologically-Based Rodent Management (EBRM), as a realistic alternative to synthetic rodenticides. The EBRM approach relies on a solid knowledge of pest rodent biology, ecology and behavior as well as the use of a pool of rodent management actions implemented through community-based interventions to ensure sustained reduction of rodent pest populations down to economically and sanitary acceptable levels. EBRM is expected not only to ensure reducing the social impacts of pest rodents in cost-beneficial ways, but also the risks of rodents and synthetic rodenticides to human health and the environment.
Religion Influence on Disaster Risk Reduction: A case study of Serbia
Authors: Cvetković Vladimir M. , Romanić Saša , Beriša Hatidža
Published: January 2023

Human perception of nature and God have always been inextricably linked. In order to understand nature and its inherent processes, including various natural hazards, the reasons for their origin were often attributed to God's will, suffering for sin and the similar. Fear of material and human losses prompted a man to pray and offer sacrifices/gifts and other rituals to appease the "wrath of the gods". The progress of civilization and technology has not alleviated the destruction and trauma that natural disasters inflict on all aspects of social life. A major obstacle to this is the exponential population growth in vulnerable areas. The frequency of natural disasters and the fatalistic attitudes that limit the effective fight against them have motivated religious communities and individuals to cooperate with international and international organizations and institutions to reduce the risk of local disasters. Believers thus receive the necessary psychological and financial assistance and support from religious communities during all phases of disaster management. Therefore, the subject of this paper is a comprehensive examination relationship between the degree of religiosity of the population and how this connection impacts the policy of reducing disaster risk. The aim of the research is to scientifically describe the nature of the relationship between the degree of religiosity of citizens and different segments of disaster risk reduction.