bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Multivariate Integral Operators Incorporating Trigonometric Transformations
Authors: Chesneau Christophe
Published: April 2024

The creation of new nonlinear multivariate integral operators is motivated by the need for mathematical tools that can handle the complex interdependencies that naturally arise in contemporary applications. From an abstract scientific point of view, it is also necessary to develop new operator theories beyond existing ones to offer original research perspectives. This article contributes to these complementary aspects. We present two nonlinear multivariate integral operators that have the particularity of incorporating trigonometric transformations of the main function. Thanks to their trigonometric nature, they completely stand out from existing operators, offering a new and complete framework. Therefore, we take advantage of advanced mathematical techniques for trigonometric functions to address the challenges they pose. In particular, we show that they have manageable integrals and series expansions, that they are solutions of specific differential and functional equations, and that they are involved in general inequalities of various types (Hölder-type, convex-type, etc.). In the application part, we use some of these properties to propose a wide collection of trigonometric inequalities that are both original and precise. Figures are produced to illustrate them for a direct visual check.
Leray Schauder Type Fixed Point Theorems in RWC-Banach Algebras and Application to Chandrasekhar Integral Equations
Authors: Amara Khaled Ben
Published: April 2024

In this paper, the existence of fixed point results of Leray Schauder type for the sum and the product of nonlinear operators acting on RWC-Banach algebras under weak topology is proved. Our results are formulated in terms of a sequential characterization of the RWC-Banach algebra and the De Blasi measure of weak noncompactness. Application to Chandrasekhar Integral equations is also given.
New Institutional Economics as a Lacatosian Scientific Research Programm
Authors:   Lomonosov Moscow State University, Izmaylov Alexander
Published: April 2024

The monograph is devoted to the subject identification of the new institutional economics (NIE) as a Lakatosian scientific research program. The first chapter compares the methodology of scientific research programs with competing approaches and justifies its use for systematizing the achievements of the NIE. The second chapter characterizes NIE as a progressive research program: its hard core and protective belt are identified, and the methodological status of NIE among other research programs of economic science is determined. The third chapter establishes promising areas of research within the protective belt of NIE, identifies opportunities for expanding the boundaries of the distribution of its tools and opportunities for interaction with other scientific research programs both in the field of economics and in related fields of science.
Control cinemático para el seguimiento de trayectorias de un manipulador 3R
Authors: Domínguez-Prado Alan Fernando , Hernández-Montalvo Ángel Isaí , Santiaguillo-Salinas Jesús , García-Lozano Hiram Nezahualcóyotl , González-Zárate Rafael Fernando
Published: April 2024

En este trabajo se presenta el diseño de una estrategia de control para lograr el seguimiento de trayectorias por parte del efector final de un robot manipulador 3R. El diseño de la estrategia de control está basado en el modelo cinemático del robot, haciendo uso del Jacobiano. Los resultados teóricos son validados numérica y experimentalmente. La implementación se realiza sobre una plataforma con un sistema de cámaras Optitrack para obtener la posición del efector final y utilizando Matlab/Simulink para el cálculo de las señales de control en tiempo real.
RELATIONSHIP BETWEEN MOTHER'S ATTITUDE AND SOCIO-CULTURE WITH THE INCIDENCE OF LACK NUTRITION IN UNDER-FREE (12-59 MONTHS)
Authors: , Kamelia , Parellangi Andi , Sinaga Elisa Goretti
Published: April 2024

Nutrition is crucial for supporting the growth and development of toddlers. The government program aimed at preventing undernutrition is the Supplementary Feeding Program (SFP). The nutritional status can be determined through laboratory tests and anthropometric measurements. The rapid developmental stage of children aged 1-5 years makes them vulnerable to undernutrition if not supported by balanced nutrition. The objective of this study was to examine the relationship between maternal attitudes, socio-cultural factors, and the occurrence of undernutrition in toddlers (12-59 months) in the village of Karangan Seberang. This research employed a descriptive correlational survey design with a cross-sectional approach. The total population of toddlers aged 12-59 months was 100 individuals, with a sample size of 86. The sampling technique used was accidental sampling. The univariate analysis revealed that 31 (36%) respondents experienced undernutrition, while 55 (64.0%) respondents did not. The bivariate analysis using the chi-square test showed a p-value of 0.000 < α value of 0.05, indicating a significant relationship between maternal attitudes, parental education, economic factors, and parental knowledge with undernutrition in toddlers (12-59 months) in the village of Karangan Seberang. There is a significant relationship between maternal attitudes, parental education, economic factors, and parental knowledge with undernutrition in toddlers (12-59 months) in the village of Karangan Seberang. Close collaboration among the government, healthcare institutions, education sector, and the community is needed to address the issue of undernutrition in children. Effective coordination and synergy between these sectors can help enhance awareness, knowledge, and effective actions in combating undernutrition.
The Adolescent’s sexual behavior and its correlates: A Systematic Review
Authors: Hastuti Puji , Yunitasari Esti , Triharini Mira , Saidah Qoriila
Published: April 2024

Abstract

 

Adolescents aged 13-15 years are a group vulnerable to risky sexual behavior. Many studies have been conducted to find the factors that influence it. This paper aims to analyze scientific evidence of factors that influence adolescent sexual behavior from various research results. The study design was a literature review on the adolescent population. Researchers conducted a literature search from empirical studies spanning the years 2017-2022 identified through the Scopus, Ebscohost, Science direct, Sage, Proquest, Springer Link and Google Scholar databases. The initial search found 8399 articles, which were narrowed down to 14 articles through inclusion criteria and exclusion criteria. The study includes research with various quantitative and qualitative designs taken from several countries. The data were analyzed using a qualitative synthesis approach. The results of the analysis show that there are many factors related to risky sexual behavior in adolescents. These factors are grouped into 4 major groups. Interpersonal factors (the role of peers), social environmental factors (economic activities, tourist interests, social norms,), individual factors (biological responses, ignorance, knowledge, lack of information, religious understanding, attitudes, self-esteem, motivation, use of social media), family factors (social economy, closeness of parents, communication between parents and children).

Keywords: Systematic review, sexual behavior, adolescents
Pembinaan Ibu Nifas Sebagai Upaya Peningkatan Keberhasilan Pemberian Asi Eksklusif Dengan Pemberian Edukasi Dan Ketrampilan Tentang Manajemen Laktasi
Authors: Kusniyati Etik , Purwati Heni
Published: April 2024

Kegagalan dalam pemberian ASI Eksklusif di pengaruhi oleh faktor internal dan factor eksternal. Faktor internal meliputi rendahnya pengetahuan dan sikap ibu, pendidikan ibu, pekerjaan ibu, pendapatan keluarga dan penyakit ibu.  Adapun factor eksternal meliputi kurangnya dukungan keluarga, masyarakat, petugas kesehatan maupun pemerintah, gencarnya promosi susu formula, faktor sosial budaya serta kurangnya ketersediaan fasilitas pelayanan kesehatan ibu dan anak. Keberhasilan menyusui ditunjang salah satunya dengan manajemen laktasi. Tujuan kegiatan pengabdian ini untuk meningkatkan pemahaman masyarakat khususnya ibu nifas tentang Manajemen laktasi dalam upaya peningkatan keberhasilan pemberian asi eksklusif. Metode yang dilakukaan pada kegiatan pengabdian ini adalah dengan melakukan penyuluhan dan pemutaran video kepada 18 ibu nifas di TPMB Fifin N.I.S., Amd.Keb. Berdasarkan hasil pre-test menunjukkan rata-rata skor nilai adalah74,00. Post test dilakukan setelah ibu nifas diberikan edukasi, hasil post test menunjukkan bahwa rata-rata skor nilai 88,22. Hasil uji statistik dengan menggunakan uji Wilcoxon Signed Rank Test, diketahui nilai ?-value = 0,000 (?-value <0,05) yang berarti terdapat perbedaan skor yang signifikan sebelum dan sesudah dilakukan pendidikan kesehatan tentang manajemen laktasi. Ada selisih 14,220 antara pre test dan post test. Pendidikan Kesehatan salah satunya adalah dengan penyuluhan perlu ditingkatkan sebagai upaya untuk mendukung keberhasilan program laktasi.
THE IMPROVING THE QUALITY OF LIFE OF THE ELDERLY THROUGH SMART MOVEMENT EFFORTS (Healthy, Independent, Active and Productive)
Authors: Triwibowo Heri
Published: April 2024

Realizing "Smart" Elderly, elderly people are closely related to various changes such as changes in anatomy/physiology, various diseases or pathological conditions as a result of aging as well as psychosocial influences on organ function. Decreased physical and psychological conditions can cause problems for the elderly. The aim of community service is to improve the quality of life of the elderly through the efforts of the SMART (Healthy, Independent, Active and Productive) movement. Preparation, implementation and reporting methods. The results of the implementation of the program to improve the quality of life of the elderly through the efforts of the SMART (Healthy, Independent, Active and Productive) movement include the formation of elderly cadres from the RT community and youth organizations and the implementation of elderly training. Community Service Activities (PKM) have been carried out in the form of education and training for elderly cadres. As well as activities for the elderly at the elderly Posyandu. The follow-up to these activities is preparing education and training for elderly cadres towards SMART elderly.
LEGAL PROTECTION FOR CONSUMERS IN ONLINE BUYING AND BUYING TRANSACTIONS OF GOODS THAT ARE NOT IN ACCORDANCE WITH THOSE OFFERED THROUGH THE LAZADA APPLICATION REVIEWED FROM AN ISLAMIC LEGAL PERSPECTIVE
Authors: Maulida Zikra
Published: April 2024

Consumer protection refers to the various measures put in place to ensure that consumers are provided with legal certainty and safeguarded from potential harm. In the context of Indonesia, consumer protection specifically pertains to online buying and selling transactions conducted through the Lazada application. These transactions involve goods that do not align with what is advertised on the platform, and are governed by the provisions outlined in Article 9 of Law Number 19 of 2016 concerning Information and Electronic Transactions. The objective of this study is to examine how consumer protection measures can be applied within the framework of Islamic law to address the issue of inappropriate goods being sold on the Lazada application. Additionally, the research aims to identify the factors contributing to consumer protection concerns in this context, as well as explore the various efforts undertaken to protect consumers when making purchases through the Lazada application. To achieve these goals, a qualitative research approach will be adopted, employing a descriptive analytical methodology and utilizing primary legal, secondary legal, and tertiary legal data sources.The findings of this study suggest that the level of consumer protection offered in online transactions for buying and selling goods through the Lazada application does not align with Islamic legal principles. Specifically, it fails to adequately consider the seller's credibility, the quality of the goods being sold, and the overall permissibility of the transaction according to Islamic law, unless there is a specific prohibition. This lack of attention to these factors can potentially expose consumers to misleading information and harm. Additionally, there are several factors and challenges that hinder the protection of consumers when using the Lazada application for shopping. These include difficulties in comparing products, navigating the shopping process, and locating specific items. Ultimately, customer complaints play a significant role in expressing dissatisfaction with the goods or services provided by the company and may cause customers to perceive online shopping on the Lazada application as ineffective.
Confiscation Of Assets In Corruption Cases Without Court Decision Through Implementation Of Deponering (Case Set-Aside) (A Study In Legal Philosophy Stream)
Authors: Syaifudin Lalu
Published: April 2024

The act of confiscation of assets is a solution to eradicate criminal acts of corruption which is used as a sanction against perpetrators of criminal acts of corruption in terms of efforts to return the proceeds of crime. The the study aims to examine legal issues related to the absence of regulations and/or norms regarding confiscation of assets without criminal prosecution which is not clearly regulated in Indonesian law and seeks solutions to the above problems in the process of reforming criminal law in Indonesia. Therefore, the title of the study is " confiscation of assets in corruption cases without court decision through implementation of deponering (case set-aside) (a study in legal philosophy stream)
A COMPARATIVE STUDY BETWEEN ISLAMIC BANKS AND ISLAMIC PAWNSHOPS
Authors: Nurlela Nurlela , Dewi Sukma
Published: April 2024

Islamic banks are banks that operate in accordance with Sharia Principles. Islamic Banking aims to support the implementation of national development in order to increase justice, togetherness, and equitable distribution of people's welfare. Pegadaian is a place where people who need cash can come to borrow money with personal items as collateral. Pawn in fiqh is called Rahn, which is a debt and credit agreement between two or more parties regarding the issue of objects and holding something as collateral or he can take some of the benefits of the goods. The benefit of this research is that it is expected to be used as input for all parties concerned to know and understand about the comparative between Islamic banks and Islamic pawnshops.
THE EFFECT OF TAX AVOIDANCE, DIVIDEND POLICY AND INCOME SMOOTHING ON THE VALUATION OF A COMPANY
Authors: Indrayani Lioni
Published: April 2024

The aim of this study is to empirically demonstrate how avoidance, dividend policy and income smoothing impact the valuation of a company. This research employs a quantity approach, utilizing purposive sampling to select samples. Hypothesis testing is conducted through panel data regression, employing E-views 9 software. The study focuses on 84 companies in the property and real estate sector listed on the Indonesian Stock Exchange (IDX) from 2017-2021. Out of these, 7 companies were selected as samples for analysis. The findings reveal the collectively, tax avoidance, dividend policy and income smoothing do not significantly impact firm value, whereas dividend policy demonstrates a positive effect on firm value
Report of 27 lichenicolous fungi species and three genera new to Finland
Authors: Puolasmaa Arto , Kuusisto Inka
Published: April 2024

Abstract: We studied systematically herbaria lichen specimens collected from Finland and from former Finnish parts of Russia to detect lichenicolous fungi. In total, 3355 lichen specimens were found with lichenicolous fungi from 160 taxa. We report here 27 species and three genera that are new to Finland. Three of these, Cercidospora epithamnolia, Cyclothyrium sp. and Roselliniella stereocaulorum, are reported as also new to Scandinavia. Three taxa are reported from a new host.
MÉTODOS UTILIZADOS PARA IDENTIFICAR PACIENTES EM CRISES PSIQUIÁTRICAS
Authors: Melo Mateus Leal De , Inacio Welligton De Souza
Published: April 2024

Introdução: A emergência psiquiátrica é identificada pelo risco iminente de vida, seja através do suicídio ou de tentativa de autolesão, bem como pela possibilidade de causar danos graves ao próprio p
PERFIL EPIDEMIOLÓGICO DE PACIENTES VÍTIMAS DE ÓBITO POR TRAUMA INTRACRANIANO NA REGIÃO NORTE
Authors: Lelis Pedro Henrique Cometti , Chagas Pedro Tiago Maia , Bastos Jorge Luiz Junior , Batista Matheus de Oliveira , Costa Marcelo Ciro Rosario da
Published: April 2024

Este estudo retrospectivo analisou dados de óbitos por traumatismo intracraniano na região norte do Brasil de 2015 a 2023. Os resultados mostraram que o traumatismo intracraniano é mais prevalente em
Manual Pratico para fundações
Authors: Paulo Junior José Marinho
Published: April 2024

O presente manual busca orientar todos os que trabalham em fundações de direito privado e não apenas os operadores de Direito. Elaborado fielmente com base nos entendimentos e convicções ministeriais com que rotineiramente trabalham as Provedorias de Fundações da Capital, do Ministério Público do Estado do Rio de Janeiro, é escrito em linguagem simples e coloquial, descomplicando os fluxos rituais e os posicionamentos jurídicos dos órgãos de execução responsáveis pelo velamento de fundações de direito privado em território fluminense, por suas sedes, subsedes, unidades de representação ou filiais. Consiste, portanto, em um guia rápido e seguro de pesquisa para os dirigentes fundacionais.
Institucionalização da arte moderna brasileira
Authors: Gonçalves Lisbeth Rebollo , Vale Fábio do , Melo Carolina Barbosa de , Teixeira Júnior João Carlos , Boaventura Maria Carolina Rodrigues , Targino Alexandre Nepomuceno , Crubelatti Vitor , Façanha Astrid Sampaio , Nastari Danielle Misura , Costa Robson Xavier da , Rascov Eduardo Cesar , Marques Cristiélen Ribeiro , Abraços Gabriela Borges , Fazzolari Claudia , Bedtche Araceli Barros da Silva Jellmayer , Marziale Nicole Palucci , Fatio Carla Francisca , Marques Helena de Madureira , Mura Cristina
Published: April 2024

Este livro, traz, portanto, a você leitor(a) pesquisador(a) ou leigo(a) da academia científica, desdobramentos responsivos cuja intelectualidade das pesquisas apresenta um desvendar de paisagens, ações que estiveram, até este momento, adormecidas pela transmissão – por parte – equívoca de muitos veículos parciais. Com a crescente das pesquisas, nosso Grupo de Pesquisas em Recepção Estética e Crítica de Arte organizou um seminário integralmente gratuito e aberto à comunidade cuja finalidade foi apresentar e disseminar aos participantes a credibilidade dos notáveis dados e informações que estávamos angariando. A inscrição e divulgação do seminário contou com o sólido Jornal da USP que nos concedeu ampla divulgação e detalhamento do cronograma do seminário que foi altamente acessível e exitoso.
Este livro traz - como produto final - a conclusão de pesquisa do pós-doutorado do pesquisador Prof. Dr. Fábio do Vale sob a orientação da professora Dra. Lisbeth Rebollo confluído com a pesquisa de outros(as) 17 pesquisadores(as) imbuídos em (re)apresentar dados da arte brasileira.
VINTE ARTISTAS BRASILEIROS NAS RELAÇÕES DIPLOMÁTICAS BRASILAMÉRICA LATINA: exposições de arte como intercâmbio cultural e político
Authors: Marques Cristiélen Ribeiro
Published: April 2024

Este artigo se concentra na exposição “20 artistas brasileños” realizada na Argentina, no Uruguai e no Chile, no contexto sociopolítico das aproximações culturais na América Latina no século XX e de um conjunto de exposições coletivas brasileiras no exterior no período de 1930 a 1945, integrado ao programa denominado Missão Cultural Brasileira, durante a “Era Vargas”. O estudo se desenvolveu com base em levantamento bibliográfico interdisciplinar e análises em torno às iniciativas de integração regional e do desenvolvimento de uma diplomacia cultural entre os países latino-americanos, bem como do cenário artístico brasileiro e das exposições no domínio das relações culturais internacionais. A partir disso, se por um lado observa-se a instrumentalização e institucionalização da produção e dos discursos artísticos em prol dos interesses geopolíticos supranacionais, também identifica-se a consolidação de um espaço de circulação e trocas artístico-culturais e de uma redes de relações cooperativas no sentido de um fortalecimento da recorrente utopia de união regional.
FORA DO EIXO: as artes visuais na Paraíba nas décadas de 1940 e 1950.
Authors: Costa Robson Xavier da
Published: April 2024

Durante as décadas de 1940 e 1950, as artes visuais na Paraíba foram marcadas pela atuação de instituições culturais e grupos de artistas que mobilizaram a cena local, seguindo na esteira das tendências modernistas, que chegaram à região durante o final da década de 1920 e na década de 1930. O objetivo desta investigação é analisar as influências modernistas nas artes visuais da Paraíba nas décadas de 1940 e 1950. Utilizamos a pesquisa qualitativa, com revisão bibliográfica e do estado da arte, partindo de textos, teses e dissertações desenvolvidas sobre o tema. Trabalhamos com a base teórica da história das exposições, abordando a temática a partir da dimensão da cena das artes visuais como reflexo do pensamento da época e como registro das ações desenvolvidas pelos artistas, grupos e instituições culturais locais, que foram fundamentais para implantar o ensino, a formação e a circulação das produções das artes visuais produzidas na Paraíba durante as décadas abordadas. A partir da análise dos dados coletados, inferimos que a produção das artes visuais na Paraíba nas décadas de 1940 e 1950, foram fundamentais para sedimentar a base necessária para as gerações seguintes de artistas visuais no estado da Paraíba.
Analysis of Modernization Readiness of Irrigation in The Downstream Brantas River Basin Under The Authority of The Central Government
Authors: Monique Adriana Swandani  , Mahendra Andiek Maulana  , Yang Ratri Savitri
Published: April 2024

In carrying out the management of the irrigation system has obstacles are inadequate infrastructure conditions caused, the irrigation infrastructure has exhausted its technical age which causes the decline in the performance function of the irrigation network. Government to farmers has not been carried out intensively. In an effort to overcome these obstacles, in addition to the operation, maintenance and rehabilitation required a renewal thoroughly, both institutional, technical, managerial, and human resources. Modernization irrigation is an effort to realize a participant irrigation management system that is oriented toward fulfilling irrigation service levels in an effective, efficient, and sustainable. Limited time, cost and human resources are obstacles in the implementation of irrigation modernization, so an assessment is needed to measure the level of readiness of an irrigation area in carrying out irrigation modernization activities. This result of analyze the readiness of irrigation modernization show that Mrican Kanan area is ready for irrigation modernization with IKMI value 81,69%. Meanwhile DI. Mrican Kiri, DI. Siman, DI. Menturus, DI, Delta Brantas needs maintenance around 1- 2 years. DI. Mrican Kanan can start from the Peterongan Secondary Channel. SI. Pare Peterongan, SI. Tunggorono, SS. Melik dan SS. Sentul.
High-temperature treatment of functional Heusler alloy Ni46Mn41In13 thin foils for microsystem devices and electronics
Authors:   Kotelnikov IRE RAS, 125009, Russia, Moscow, Kuznetsov D.D. , Kuznetsova E.I. ,   M.N. Mikheev Institute of Metal Physics of Ural Branch RAS, 620108, Russia, Ekaterinburg, Danilov D.V. ,   IRC for Nanotechnology of the Science Park of St. Petersburg State University, 199034, Russia, St. Petersburg, Musabirov I.I. ,   Institute for Metals Superplasticity Problems RAS, 450001, Russia, Ufa, Prokunin A.V. ,   Kotelnikov IRE RAS, 125009, Russia, Moscow, Koledov V.V. ,   Kotelnikov IRE RAS, 125009, Russia, Moscow, Shavrov V.G. ,   Kotelnikov IRE RAS, 125009, Russia, Moscow
Published: April 2024

In this study, the high-temperature transformation in a thin foil of non-stoichiometric Heusler alloy based on Ni-Mn-In is investigated using in-situ TEM. The highly ordered cubic L21 phase undergoes decomposition upon heating, forming a phase with a composition close to Ni75Mn25, which is identified as disordered FCC-Ni3Mn and secondary phases, mainly manganese oxides and sulfides. All phases formed upon heating to a temperature of 1173 K are preserved during the in-situ cooling experiment to a temperature of 123 K.
A clinical case of a severe course of the COVID-­19 in a patient with primary progressive multiple sclerosis
Authors: GOLUBOVSKA O.A. , BEZRODNA O.V. , MELNYK V.S. , SHOLOMON S.M.
Published: April 2024

Coronavirus disease-2019 (COVID-19), despite the emergence of new pathogen variants, remains the leading cause of acute respiratory viral infections and can be severe in patients with concomitant chronic diseases, including multiple sclerosis (MS). Increased risks of complicated COVID-19 were more often observed in elderly MS patients, males, those with significant physical activity limitations, and progressive disease. While the majority of patients in this category, according to the literature, were characterised by a mild course of COVID-19, even compared to the general population. There are reports that the prolonged quarantine that accompanied the coronavirus pandemic had a negative impact on patients with progressive MS by reducing patients’ physical activity, increasing body weight, and increasing the incidence of depression. Primary progressive MS patients account for about 15 % of all MS patients. They are characterised by a relatively rapid increase in disability and limitation of motor activity. The article presents a clinical case of severe coronavirus disease in an elderly patient with primary progressive MS. The authors note the wave-like course of the immunopathological stage of COVID-19, which was characterised by both the increase in signs of intoxication, fever and respiratory failure, and the prolonged preservation of elevated markers of the inflammatory process (C-reactive protein). Positive dynamics was obtained after prescribing intravenous immunoglobulins, but the patient’s motor activity was significantly limited, general weakness and fatigue increased, and the ability to care for oneself in bed remained. The patient lost the ability to independently move from the bed to the wheelchair.
Overview of the Lipid Peroxidation Measurements in Patients by the Enzyme-Linked Immunosorbent Assay Specific for the 4-Hydroxynonenal-Protein Adducts (4-HNE-ELISA)
Authors: Žarković Neven , Gęgotek Agnieszka , Łuczaj Wojciech , Jaganjac Morana , Šunjić Suzana Borović , Žarković Kamelija , Skrzydlewska Elzbieta
Published: April 2024

Oxidative stress often affects the structure and metabolism of lipids, which in the case of polyunsaturated free fatty acids (PUFAs) leads to a self-catalysed chain reaction of lipid peroxidation (LPO). The LPO of PUFAs leads to the formation of various aldehydes, such as malondialdehyde, 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, and 4-oxo-2-nonenal. Among the reactive aldehydes, 4-HNE is the major bioactive product of LPO, which has a high affinity for binding to proteins. This review briefly discusses the available information on the applicability of assessment options for 4-HNE and its protein adducts determined by immunosorbent assay (the 4-HNE-ELISA) in patients with various diseases known to be associated with oxidative stress, LPO, and 4-HNE. Despite the differences in the protocols applied and the antibodies used, all studies confirmed the usefulness of the 4-HNE-ELISA for research purposes. Since different protocols and the antibodies used could give different values when applied to the same samples, the 4-HNE-ELISA should be combined with other complementary analytical methods to allow comparisons between the values obtained in patients and in healthy individuals. Despite large variations, the studies reviewed in this paper have mostly shown significantly increased levels of 4-HNE-protein adducts in the samples obtained from patients when compared to healthy individuals. As with any other biomarker studied in patients, it is preferred to perform not only a single-time analysis but measurements at multiple time points to monitor the dynamics of the occurrence of oxidative stress and the systemic response to the disease causing it. This is especially important for acute diseases, as individual levels of 4-HNE-protein adducts in blood can fluctuate more than threefold within a few days depending on the state of health, as was shown for the COVID-19 patients.
Female Type 1 Diabetic Akita Mice Demonstrate Increased Bladder Contractility via FP Receptor Activation due to NLRP3-Mediated Inflammation
Authors: Odom Michael R. , Hughes. Francis M. , Pope NiQuava , Jin Huixia , Purves J. Todd
Published: April 2024

Background: Diabetic bladder dysfunction (DBD) is driven in part by inflammation which dysregulates prostaglandin release in the bladder. Precise inflammatory mechanisms responsible for such dysregulation have been elusive. Since prostaglandins impact bladder contractility, elucidating these mechanisms may yield potential therapeutic targets for DBD. In female Type 1 diabetic Akita mice, inflammation mediated by the nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) inflammasome is responsible for DBD. Here, we utilized female Akita mice crossbred with NLRP3 knock-out mice to determine how NLRP3-driven inflammation impacts prostaglandin release within the bladder and prostaglandin-mediated bladder contractions. Methods: Akita mice were crossbred with NLRP3-⁣/- mice to yield four groups of non-diabetics and diabetics with and without the NLRP3 gene. Females were aged to 30 weeks when Akitas typically exhibit DBD. Urothelia and detrusors were stretched ex vivo to release prostaglandins. Prostaglandin E2 (PGE2) and prostaglandin F2α (PGF2α) were quantified using enzyme linked immunosorbent assays (ELISA). In separate samples, ex vivo contractile force to PGE2 and PGF2α +/– the prostaglandin F (FP) receptor antagonist, AL8810, was measured. FP receptor protein expression was determined via western blotting. Results: Stretch-induced PGE2 release increases in urothelia but decreases in detrusors of diabetics. However, PGE2-mediated bladder contractions are not impacted. Conversely, diabetics show no changes in PGF2α release, but PGF2α-mediated contractions increase significantly. This is likely due to signaling through the FP receptors as FP receptor antagonism prevents this increase and diabetics demonstrate a four-fold increase in FP receptor proteins. Without NLRP3-mediated inflammation, changes in prostaglandin release, contractility, and receptor expression do not occur. Conclusion: NLRP3-dependent inflammation dysregulates prostaglandin release and prostaglandin-mediated bladder contractions in diabetic female Akita mice via FP receptor upregulation.
Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease
Authors: Hillan Sydney G. , Asp Anders J. , Pramanik Leena B. , Mukerjee Aarushi A. , Mulder Carter B. , Lujan Wendy D. , Silvernail Jodi L. , Chang Su-Youne , Boschen Suelen L. , Lujan J. Luis
Published: April 2024

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson’s disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and anxiety is one of the most common. The relationship between PD and anxiety is complex and can be a result of both pathological neural changes and the psychological and emotional impacts of living with a chronic progressive condition. Managing anxiety in PD is critical for improving the patients’ quality of life. However, patients undergoing STN DBS can occasionally experience increased anxiety. Methods: This study investigates changes in risk-avoidant behavior following STN DBS in a pre-motor animal model of PD under chronic and acute unilateral high frequency stimulation. Results: No significant changes in risk-avoidant behaviors were observed in rats who underwent STN DBS compared with sham stimulation controls. Chronic stimulation prevented sensitization in the elevated zero maze. Conclusions: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.
Exploring the Impact of Cardiac Rehabilitation Programs on Health-Related Quality of Life and Physiological Outcomes in Patients Post Coronary Artery Bypass Grafts: A Systematic Review
Authors: Subih Maha , Elshatarat Rami A. , Sawalha Murad A. , Almarwani Abdulaziz Mofdy , Alhadidi Majdi , Alrahahleh Mohammad , Elneblawi Nora H. , Saleh Zyad T. , Abdelkader Raghad , Almagharbeh Wesam T. , Eltayeb Mudathir M. , Mohamed Nermen A.
Published: April 2024

Background: This systematic review explores the impact of cardiac rehabilitation programs (CRPs) on health-related quality of life (HRQoL) and physiological outcomes post-coronary artery bypass graft (CABG) surgery. Acknowledging the increasing importance of CRPs in post-CABG care, the study emphasizes the need for a comprehensive evaluation of their effectiveness. The primary objective is to investigate how CRPs influence HRQoL and physiological outcomes in post-CABG patients, offering insights into the multifaceted impact of these rehabilitation programs. Methods: A systematic literature review approach was employed to identify relevant studies published between 2013 and 2023. Inclusion criteria encompassed clinical randomized trials and quasi-experimental studies, with a focus on CRP interventions and their impact on HRQoL and physiological parameters. Results: The review reveals a diverse array of CRP approaches, including exercise training, home-based programs, and telemonitored interventions. Despite methodological variations, a consistent positive impact on HRQoL and physiological outcomes is observed across studies. Noteworthy interventions, such as those incorporating family caregivers, demonstrate holistic benefits. However, limitations include methodological variability and the exclusion of qualitative studies. Conclusions: This systematic review underscores the substantial positive impact of CRPs on HRQoL and physiological outcomes in post-CABG patients. The diverse approaches and consistent improvements across studies provide a robust foundation for healthcare practitioners and researchers. Future efforts should focus on standardizing CRP interventions and conducting well-designed trials to further enhance the evidence base, facilitating more targeted and effective rehabilitation strategies for CABG patients.
Outcomes of Mitral Valve Repair for Posterior Leaflet Prolapse, Anterior Leaflet Prolapse, and Bileaflet Prolapse
Authors: Liu Kemin , Ye Qing , Zhao Yichen , Zhao Cheng , Song Li , Liu Yang , Bai Chen , Han Jie , Wang Shengyu , Wang Jiangang
Published: April 2024

Background: Mitral valve repair (MVr) is an effective treatment for degenerative mitral regurgitation (DMR).And the outcomes and repair rates for posterior leaflet prolapse (PLP), anterior leaflet prolapse (ALP), and bileaflet prolapse (BLP) vary. This study aimed to compare the outcomes of mitral valve repair for patients with PLP, ALP, and BLP. Methods: From 2010 to 2019, 1192 patients with degenerative mitral valve regurgitation underwent surgery at our hospital. And 1069 patients were identified. The average age of all patients was (54.74 ± 12.17) years old for all patients. 273 patients (25.5%) had ALP, 148 patients (13.8%) had BLP, and 648 patients (60.6%) had PLP. All patients were followed up for an average duration of 5.1 years. We compared the outcomes of patients with ALP, PLP, and BLP. Results: Patients with ALP were the youngest of the 3 groups and had the highest prevalence of atrial fibrillation. Patients with PLP had the highest prevalence of hypertension, whereas patients with BLP and ALP had larger left ventricular end-diastolic and left ventricular end-systolic diameters. ALP and BLP repairs had a longer cardiopulmonary bypass and aortic cross-clamp time.10 patients dead in-hospital, 5 patients had PLP, 3 had ALP, and 2 had BLP. The 10-year survival cumulative incidences of reoperation among ALP, BLP, and PLP repairs were not significantly different. ALP repair still had higher cumulative incidences of recurrent mitral regurgitation (MR) compared to PLP. Conclusions: The rates of long-term survival and freedom from reoperation were not significantly different among patients with ALP, BLP, and PLP. ALP repair has higher cumulative incidences of recurrent MR compared to PLP.
MAINTENANCE STRATEGY REVIEW (MSR) BASED ON ISO 14224:2016 IN INDONESIA OIL AND NATURAL GAS COMPANIES
Authors: Setyoko Ajun Tri , Nurcahyo Rahmat , Adipraja Aulia Sena , Budiono Hendri Dwi Saptrioratri
Published: April 2024

The oil and gas industry is vital for Indonesia, and the safety and effectiveness of work in processing and exploring the oil and gas that operate in Indonesia must comply with existing regulations. This safety and effectiveness are inseparable from how the company maintains the assets and instruments used at the oil and gas production and exploration site. Maintenance of pipes and instruments for production is one of the company's most vital assets. In addition to having appropriate productivity, pipes and instruments must be maintained optimally so that maintenance costs do not exceed the value of the oil and gas production. This study's research subject is a natural gas refinery from an oil and gas company operating in the Madura Strait, East Java, Indonesia. The object of research limited to the company's piping system (pipeline system). This study uses a quantitative assessment using the calculated Mean Time Before Failure (MTBF) method and a qualitative assessment using the asset maintenance standard to  reveals how the maintenance cycle that has been implemented can be optimized. The author carried out a criticality assessment using Maintenance Strategy Review (MSR) to calculate the risk level of asset. This study found that 78 assets must be maintained in their maintenance cycle, two cash assets must be reduced in their maintenance cycle, and seven assets can be extended for their maintenance cycle. The two assets that need to be reduced in maintenance cycles are the shutdown valve asset that goes to the temporary pig receiver and the shutdown valve that goes to the HP flare header. An asset that can be extended its maintenance cycle is a transmitter for flow indicators.

 
Matters Arising: A Response to Loneliness and suicide mitigation for students using GPT3-enabled chatbots
Authors: Zimmerman Julia Witte , Ruiz Alejandro J.
Published: April 2024

In their recent paper, Maples et al. surveyed users of the Replika app. Among their results, they reported that participants were relatively lonely and used Replika for diverse purposes, and emphasized that "3% reported that Replika halted their suicidal ideation". However, important context about how Replika has been marketed and used was missing. We provide context about Replika's sexual component, and discuss the threat of industry interests to scientific integrity.
Measuring self-similarity in empirical signals to understand musical beat perception
Authors: Lenc Tomas , Lenoir Cédric , Keller Peter E. , Polak Rainer , Mulders Dounia , Nozaradan Sylvie
Published: April 2024

Experiencing music often entails the perception of a periodic beat. Despite being a widespread phenomenon across cultures, the nature and neural underpinnings of beat perception remain largely unknown. In the last decade, there has been a growing interest in developing methods to probe these processes, particularly to measure the extent to which beat-related information is contained in behavioral and neural responses. Here, we propose a theoretical framework and practical implementation of an analytic approach to capture beat-related periodicity in empirical signals using frequency-tagging. We highlight its sensitivity in measuring the extent to which the periodicity of a perceived beat is represented in a range of continuous time-varying signals with minimal assumptions. We also discuss a limitation of this approach with respect to its specificity when restricted to measuring beat-related periodicity only from the magnitude spectrum of a signal, and introduce a novel extension of the approach based on autocorrelation to overcome this issue. We test the new autocorrelation-based method using simulated signals and by re-analyzing previously published data, and show how it can be used to process measurements of brain activity as captured with surface EEG in adults and infants in response to rhythmic inputs. Taken together, the theoretical framework and related methodological advances confirm and elaborate the frequency-tagging approach as a promising window into the processes underlying beat perception and, more generally, temporally coordinated behaviors.
Hubungan Antara Volume Ambing Dan Panjang Puting Terhadap Produksi Susu Sapi Perah Friesian Holstein Di Desa Pesanggrahan Kota Batu
Authors: Marshaniswah Ignacia Farah , Surjowardojo Puguh
Published: April 2024

The Purpose of this study was to determine the relationship between udder volume and teats length with milk production in Friesian Holstein dairy cows in Pesanggrahan Village, Batu City, East Java. The research was conducted for one month from August to September 2023. The materials used were 30 Friesian Holstein dairy cows in lactation phase 2-3 and lactation month 2-3. The method used was case study method. Parameters measured included udder volume, teats length and milk production. Analysis of the relationship between research variables using correlation analysis and simple linear regression, where udder volume and teats length as independent variables (X) and milk production as the dependent variable (Y). The results showed that there was a relationship between udder volume and milk production and a very weak relationship between teats length and milk production. The conclusion of this study is that udder volume has a relationship with milk production, while teats leght has a insignificant relationship with milk production so that teats leght only affects milking effectiveness. Thus, udder volume is a considered more relevant as a variable in predicting the amount of milk produced by dairy cows.   Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara volume ambing dan panjang puting dengan produksi susu pada sapi perah Friesian Holstein di Desa Pesanggrahan, Kota Batu, Jawa Timur. Penelitian dilakukan selama satu bulan dari bulan Agustus hingga September 2023. Materi yang digunakan adalah 30 ekor sapi perah Friesian Holstein periode laktasi II-III dan laktasi bulan ke 2-3. Metode yang digunakan adalah metode studi kasus. Parameter yang diukur meliputi volume ambing, panjang puting dan produksi susu. Analisis hubungan antar variabel penelitian menggunakan analisis korelasi dan regresi linier sederhana, dimana volume ambing dan panjang ambing sebagai variabel bebas (X) dan produksi susu sebagai variabel terikat (Y). Hasil penelitian menunjukkan bahwa terdapat hubungan antara volume ambing dengan produksi susu dan terdapat hubungan yang sangat lemah antara panjang ambing dengan produksi susu. Kesimpulan dari penelitian ini adalah volume ambing memiliki hubungan dengan produksi susu, sedangkan panjang ambing memiliki hubungan yang tidak signifikan dengan produksi susu sehingga panjang ambing hanya berpengaruh terhadap efektivitas pemerahan. Dengan demikian, volume ambing dianggap lebih relevan sebagai variabel dalam memprediksi jumlah susu yang dihasilkan oleh sapi perah
Association of Fuchs Heterochromic Iridocyclitis with Multiple Sclerosis
Authors: Brichová Michaela , Lízrová Preiningerová Jana , Heissigerová Jarmila , Jeníčková Dagmar , Klímová Aneta , Svozílková Petra
Published: April 2024

Purpose: To draw attention to the higher proportion of Fuchs heterochromic iridocyclitis (FHI) cases in patients with multiple sclerosis (MS).

Materials and Methods: Retrospective study of data collected at the Center for the Diagnosis and Treatment of Uveitis.

Results: An analysis of the medical records of 3016 patients with uveitis (in the years 2003–2020) was performed with a focus on MS. MS-associated uveitis was diagnosed in 90 patients (3%): anterior uveitis (n = 7), intermediate uveitis (n = 23), retinal vasculitis (n = 24), and panuveitis (n = 36). A clinical examination revealed signs of FHI in the anterior segment in 11 out of 90 cases (12%). Atypical manifestations of FHI included a higher incidence of bilateral involvement (45%), retinal vasculitis (27%), and vitreous snowballs (18%). The diagnosis of FHI preceded the diagnosis of MS in 4 cases. The median latency was 10.5 (range 8–15) years. In 4 patients, the diagnosis of demyelinating disease was established within one year of the diagnosis of FHI. We recommended a neurological examination for optic neuritis (n = 1), paresthesia (n = 3), relapse of motor deficit (n = 1), and screening of etiology in cases with involvement of the posterior segment (n = 3). In the other 3 cases, the diagnosis of MS preceded the diagnosis of FHI, with a median latency of 13 (range 8–19) years.

Conclusion: We detected clinical symptoms of FHI in 12% of uveitis cases associated with MS, more often in bilateral manifestations of intraocular inflammation. Based on our experience, we recommend an investigation of the medical history of patients with FHI for manifestations of sensitive, sensory and motor deficits, especially in bilateral cases.
The embodiment of the heroic deed of the Soviet people in the Great Patriotic War on a postal miniature
Authors: Orekhova Svetlana Evgenevna
Published: April 2024

The article deals with a practical justification for the affiliation of postage stamps to written sources. The experience of using the means of political agitation, among which special importance was assigned to postage stamps, in order to mobilize the Soviet people to fight the enemy, is analyzed. The methodological essence of this problem corresponds to the principles of historicism, objective reflection of reality, dialectical, which are implemented using chronological, comparative methods, as well as quantitative analysis. Postal miniatures of the USSR are marked by high cognitive and artistic and aesthetic advantages.
Lymphadenopathy Presenting as Rosai- Dorfman- Destombes Disease: A Rare Case Report
Authors: Hashim AlBedwawi Moaza
Published: April 2024

Rosai-Dorfman-Destombes disease is a very rare benign disorder of histiocyte proliferation with unknown etiology. We report the case of a 41 years old man diagnose with this disease, having had long standing cervical lymphadenopathy increasing in size. This case is presented given the difficulty in diagnosis and surgical management on skin involvement.