bluuebunny/crossref_metadata_2025 huggingface dataset:
Precautions for Pneumo-Orbital in Cases of Maxillofacial Trauma: Data Mining for Artificial Inteligence of Air Localization on CT-Scan
Authors: Kalua Karla , Hanafi Muchtar , Rahayu Rachmi Fauziah
Published: April 2023

Along with rapid mobility, the incidence of traffic accidents is increasing. Maxillofacial trauma often accompanies traffic accidents. Facial bone fractures need serious concern, considering that the face contains several important organs and an important aesthetic aspect daily. Pneumo-orbital, in which air is found in the orbital cavity, is a threat to vision. The development of diagnostic modalities for maxillofacial trauma is developed continuously for determining the accuracy and improving rapid diagnosis. A radiologist is greatly facilitated by the presence of a CT scan that is able to detect certain abnormalities through artificial intelligence (AI) features. The data of this study are preliminary data showing the incidence of pneumo-orbital that was often missed in maxillofacial trauma cases. The maxillofacial trauma cases (classified as Le Fort fractures) were collected from January 2022 to July 2022 consecutively and determined into Le Fort fractures with pneumo-orbital and without pneumo-orbital. From 19 cases, 13 cases (68%) were accompanied by pneumo-orbital, while 6 cases (32%) were not. Multiple pneumo-orbitals with relatively visible sizes are detected easily on CT scan but a single and relatively small pneumo-orbital has potentially not to be seen on CT scan. It is concluded that CT scan nowadays is not only used to see anatomical abnormalities, but also equipped with AI-based features; such as the intracranial bleeding volume calculation and calcium score estimation on cardiac CT. It is possible that a CT scan can also detect the presence of air particles. Thus, the sensitivity of pneumo-orbital detection can be increased.
Septic Cavernous Sinus Thrombosis (CST) with Blindness Caused by Odontogenic Infection – A Case Report
Authors: Valentine Putri Permata , Adrianto Yudhi , Setyowatie Sita
Published: April 2023

Introduction: Septic cavernous sinus thrombosis (CST) is a rare thrombosis, but severe, causing damage to all nerves inside the cavernous sinus. The incidence rate of CST is estimated at two to four per million people per year. The symptom usually varies, gradually worsening, making diagnosis harder and potentially making permanent disability. Early detection and prompt treatment are very important to lower the morbidity rate. Case: Tn. M had complained of multiple headaches attacks since 8 months ago before being admitted followed by diplopia. Complaints had worsened 3 months before with the loss of vision in the left eye. MRI showed left thrombosis sinus cavernous. The terrible headache was scaled 8-9 with VAS score. The patient’s left eye was found proptosis palpebra, with anisocoria and mydriasis followed by no direct light reflex also indirect light reflex, visual acuity of the left eye is no light response, whereas the patient’s right eye is normal. On the patient’s left eye was found gaze palsy sinistra. The abnormal blood result was leucocytosis and thrombocytosis. The patient was given fondaparinux once a day with a dose of 6000 units subcutaneously for 5 days. After that, the headache was decreased significantly. The patient underwent 5 tooth extraction done by mouth surgeon after being discharged. The patient was given 20 mg rivaroxaban per day for three weeks, then 10mg per day for three months, and evaluated with MRV again. Conclusion: CST is still very rare but very lethal and makes permanent disability on the patient. Through this case, we demonstrate the potential of tooth infection which leads to septic CST and caused ophthalmoplegia and blindness.
Pengaruh Pemanfaatan Media Sosial, Kreativitas, dan Kecerdasan Emosional terhadap Minat Berwirausaha Mahasiswa di Jakarta
Authors: Maharani Anisa , Corry Yohana  , Aditya Pratama
Published: April 2023

The purpose of this study is to ascertain the effect of social media utilization, creativity, and emotional intelligence on student’s entrepreneurship interest in Jakarta. The type of data used in quantitative. The sampling technique was purposive sampling to 150 respondents who were included in the research criteria. The data was obtained usimg a survey method with Likert Type. The data anlysis technique used is multiple linear regression analysis using SPSS version 25. Based on the test results, it was stated that the utilization of social media had a positive and significant effect on interest in entrepreneurship, creativity had a positive and significant effect on interest in entrepreneurship and emotional intelligence had a positive and significant effect on interest in entrepreneurship. The coefficient of determination in this study was 47,4% which showed the social media utilization, creativity and emtional intelligence on student’s entrepreneurship interest in Jakarta while unstudied additional factors affected the remainder.

 

Penelitian ini bertujuan untuk mengetahui pengaruh pemanfaatan media sosial, kreativitas, dan kecerdasan emosional terhadap minat berwirausaha mahasiswa di Jakarta. Metode yang digunakan pada penelitian ini adalah metode kuantitatif. Teknik pengambilan sampel secara purposive sampling kepada 150 responden yang termasuk kedalam kriteria penelitian. Data didapatkan menggunaka metode survei dan instrumen kuesioner dengan skala likert. Dengan teknik analisis regresi linear berganda menggunakan bantuan aplikasi SPSS versi 25.0. Berdasarkan hasil pengujian hipotesis dinyatakan bahwa pemanfaatan media sosial berpengaruh secara positif dan signifikan terhadap minat berwirausaha, kreativitas berpengaruh secara positif dan signifikan terhadap minat berwirausaha serta kecerdasan emosional berpengaruh positif dan signifikan terhadap minat berwirausaha. Koefisien determinasi pada penelitian ini adalah 48,5% yang menunjukkan pemanfaatan media sosial, kreativitas dan kecerdasan emosional memengaruhi minat berwirausaha, sedangkan sisanya dipengaruhi faktor lain yang tidak diteliti.
Faktor-faktor yang Mempengaruhi Online Shopping Intention pada Produk Vitamin di DKI Jakarta
Authors: Herdina Ekky Octavianty  , Andi Muhammad Sadat  , Dewi Agustin Pratama Sari
Published: April 2023

Penelitian ini bertujuan untuk menguji faktor-faktor yang mempengaruhi online shopping intention produk vitamin di DKI Jakarta selama pandemi Covid-19. Ada enam tiga variabel yang digunakan yaitu online shopping anxiety, perceived ease of use, dan perceived benefit. Peneliti menggunakan metode kuantitatif dengan menyebarkan kuesioner melalui Google Form. Peneliti menggunakan sampel sebanyak 250 responden yang pernah melakukan belanja produk vitamin di e-commerce minimal dua kali selama pandemi, berdomisili di DKI Jakarta, dan berusia ≥17 tahun. Data diolah menggunakan IBM SPSS Statistics 22 dan AMOS versi 21. Hasil penelitian menunjukkan bahwa pengaruh online shopping anxiety terhadap online shopping intention adalah signifikan negatif, pengaruh perceived ease of use terhadap online shopping intention adalah signifikan positif, pengaruh perceived benefit terhadap online shopping intention adalah signifikan positif dan pengaruh online shopping anxiety terhadap perceived ease of use adalah signifikan negatif.

Kata Kunci: Online Shopping Anxiety, Perceived Ease of Use, Perceived Benefit, Online Shopping Intention, Produk Vitamin, E-Commerce
Application of Group Method of Data Handling via a Modified Levenberg-Marquardt Algorithm in the Prediction of Compressive Strength of Oilwell Cement with Reinforced Fly Ash Based on Experimental Data
Authors: Nyakilla Edwin E. , Jun Gu , Charles Grant , Ricky Emanuel X. , Hussain Wakeel , Iqbal Sayed Muhammed , Kalibwami Daud C. , Alareqi Ahmed G. , Shaame Mbarouk , Ngata Mbega Ramadhani
Published: April 2023

The experimental design of well cement with durable compressive strength (CS) is challenging and time-consuming. The current research predicts CS using the enhanced group method of data handling via a modified Levenberg-Marquardt algorithm (GMDH-LM) with experimental data. Class F fly ash (CFFA) is used as a supplementary material to cement at various proportions. Experimental tests of CS, thermogravimetric (TG) analysis, rheology, and scanning electron microscopy (SEM) are applied. Experimental findings revealed that the addition of fly ash (FA) enhances CS with curing time as an outcome of pozzolanic action. CS for 20% FA reinforcement after curing for 28 days was 42.95 MPa, compared with 41.53 MPa for 50%. This indicates that a higher addition of FA lowers CS. The rheological findings revealed that FA enhanced the viscosity of the cement slurry. The SEM images demonstrated that the incorporation of CFFA with cement modified the contexture of hardened cement. Cement, water, oilwell cement (OWC), curing time, dispersant, and FA were assigned as input variables for GMDH-LM while CS from the experimental analysis was set as output. Machine learning (ML) findings indicated that GMDH-LM can effectively estimate the CS of OWC. GMDH-LM performed better than backpropagation neural network (BPNN), support vector machine (SVM), and normal GMDH models in predicting CS; it provided higher linearity during training as GMDH-LM gave R2 = 0.958, GMDH = 0.946, SVM = 0.925, BPNN = 0.897, and the least loss functions of mean square error (MSE) = 0.238, MSE = 1.685, MSE = 2.567, and MSE = 4.032, respectively. Similarly, good results were ascertained during testing GMDH-LM provided R2 = 0.928, GMDH = 0.907, SVM = 0.895, BPNN = 0.878, and the lowest loss functions of MSE = 0.304, MSE = 2.650, MSE = 3.494, and MSE = 5.678, respectively. Therefore, the comparative results of all experiments and predictions reveal that GMDH-LM can be deployed as an advanced approach for the estimation of cement hydration in oil and gas wells.
The use of evidence to guide decision-making during the COVID-19 pandemic: Divergent perspectives from a qualitative case study in British Columbia, Canada
Authors: Brubacher Laura Jane , Lovato Chris Y , Sri Veena , Cheng Michael , Berman Peter
Published: April 2023

Background: The challenges of evidence-based decision-making in a public health emergency have never been so notable as during the COVID-19 pandemic. Questions about the decision-making process, including what forms of evidence were used, and how evidence informed – or did not inform – policy have been debated.
Methods: We examined decision-makers' observations on evidence-use in early COVID-19 policy-making in British Columbia (BC), Canada through a qualitative case study. From July 2021- January 2022, we conducted 18 semi-structured key informant interviews with BC elected officials, provincial and regional-level health officials, and civil society actors involved in the public health response. The questions focused on: 1) the use of evidence in policy-making; 2) the interface between researchers and policy-makers; and 3) key challenges perceived by respondents as barriers to applying scientific evidence to COVID-19 policy decisions.
Data were analyzed thematically, using a constant comparative method. Framework analysis was also employed to generate analytic insights across stakeholder perspectives.
Results: Overall, while many actors’ impressions were that BC's early COVID-19 policy response was evidence-informed, an overarching theme was a lack of clarity and uncertainty as to what evidence was used and how it flowed into decision-making processes. Perspectives diverged on the relationship between 'government' and public health expertise, and whether or not public health actors had an independent voice in articulating evidence to inform pandemic governance. Respondents perceived a lack of coordination and continuity across data sources, and a lack of explicit guidelines on evidence-use in the decision-making process, which resulted in a sense of fragmentation. The tension between the processes involved in research and the need for rapid decision-making was perceived as a barrier to using evidence to inform policy.
Conclusions: Areas to be considered in planning for future emergencies include: information flow between policy-makers and researchers, coordination of data collection and use, and transparency as to how decisions are made—all of which reflect a need to improve communication. Based on our findings, clear mechanisms and processes for channeling scientific evidence into decision-making need to be identified, and doing so will strengthen preparedness for future public health crises.
Quantifying Preferences for Urea Cycle Disorder Treatments Using a Discrete Choice Experiment
Authors: Edelblut Josiah , Skaar Jeffrey R , Hilton John , Seibt Matthew , Martin Kyle , Hadker Nandini , Quartel Adrian , Steiner Robert
Published: April 2023

Background Urea cycle disorders (UCDs) are rare, inherited metabolic disorders that can lead to central nervous system toxicity due to ammonia accumulation. Nitrogen-binding medications can be efficacious in the treatment of UCDs but may be associated with attributes that negatively impact adherence. This study sought to quantify the attributes of these medications influencing overall prescription and patient adherence. Results A web-based, quantitative survey including discrete choice experiment (DCE) methodology captured responses from health care providers for patients with UCDs. In the DCE, respondents were presented with a series of hypothetical treatment profile sets that described treatment attributes such as route of administration, taste/odor, preparation instructions, packaging, dose measurement, and weight use restrictions. From 16 choice sets, with 3 hypothetical product profiles, respondents evaluated the product attributes most preferred for overall treatment selection or for patient adherence. A total of 51 respondents completed the survey. Respondents reported dissatisfaction with current treatments [mean rating (SD) = 5.4 (1.7); Likert scale with 1 = not at all satisfied through 9 = extremely satisfied]. Using DCE methodology, four attributes achieved relative importance (RI) scores > 16.67% [i.e., 100/6 (number of attributes), the value if all attributes were considered of equal importance] indicating higher overall preference: taste/odor (24%), weight restrictions (21%), preparation instructions (18%), and route of administration (17%). When considering adherence, three attributes achieved RI scores > 16.67%: taste/odor (28%), preparation instructions (21%), and route of administration (17%). Within the taste/odor attribute, preference weights for “taste/odor masked” were higher than “not taste/odor masked” for overall preference for prescribing [mean (SD); 1.52 (1.10) vs -1.52 (1.10)] and preference for treatment adherence [mean (SD); 73.8 (55.2) vs -73.8 (55.2)]. Conclusions Taste/odor was the most important attribute influencing overall preference for both prescribing and for patient adherence and compliance, with taste/odor masking preferred. Optimizing nitrogen-binding medications to encourage increased patient adherence through masking taste/odor may support improved outcomes in UCDs.
The Design and Implementation of a Novel Pharmacogenomic Assay to Genotype the CYP3A53 (rs776746) and CYP3A51E (rs4646453) Genetic Variants
Authors: Sameem Reema , Noordeen Nafeesa , Praveenan Somasundaram , Wetthasinghe Tithila Kalum , Dissanayake Vajira Harshadeva Weerabaddana
Published: April 2023

Background The cytochrome P450 3A5 CYP3A5 enzymes are important for metabolizing the drug tacrilomus, an immunosuppressive agent used in solid organ transplantation. Genetic variants in the CYP3A5 gene are significant determinants of tacrolimus efficacy. The present study was undertaken to design a novel pharmacogenetic assay (Single step-Tetra Arms Polymerase Chain Reaction) to study the distribution of the CYP3A5*3 (rs776746) and CYP3A5*1E (rs4646453) variants by genotyping a cohort of healthy individuals.Results The CYP3A5*3 variant was the most frequent allele detected at 82% and the CYP3A5*1E C allele was found in 66.5% of the samples. The allele frequencies of CYP3A5*3 (rs776746) and CYP3A5*1E (rs4646453) were statistically significant (p < 0.05) when compared with the Asian ethnic group. The observed CYP3A5 genotype frequency distributions for the CYP3A5*3 (rs776746) and CYP3A5*1E (rs4646453) variants in the study population were consistent with the Hardy–Weinberg equilibrium (P > 0.05). For the CYP3A5*3 variant the frequency of the T/T [extensive metabolizer], C/T [intermediate metabolizer] and C/C [poor metabolizer] variants were 4%, 28% and 68% respectively. Furthermore, a significant linkage disequilibrium among rs4646453 and rs776746 was identified (p < 0.05).Conclusions A novel tetra-primer ARMS PCR assay was successfully designed and implemented for genotyping of the CYP3A5 variants CYP3A5*3 (rs776746) and CYP3A5*1E (rs4646453). These pharmacogenomic assays could be offered to patients to predict their response to tacrolimus.
WITHDRAWN: The Difference in Fine Motor Performance Between Saudi Boys and Girls in Preschool Age: A Pilot Study
Authors: Alsakhawi Reham , Aleidi Jasmine , Almutairi Renad , Alrifaei Sara , Alnutifi Abeer , Almutiri Rawan
Published: April 2023

Background
Fine motor skills in form of grasping and visual motor integration are essential to social and emotional adaptation in preschool age, it may different in age and gender which affect the performance of the child in school.
Methods
Three hundred children aged three to six years old were recruited at public and private preschools in Riyadh, Saudi Arabia. The 150 boys and 150 girls were divided into three groups each by age: (1) three to four years, (2) four to five years and (3) five to six years. Fine motor skills were assessed one time using the grasping and visual-motor integration subtests of the Peabody Developmental Motor Scales, Second Edition (PDMS-2). The raw scores and age equivalences of the subtests were evaluated.
Results
There were no significant gender differences in the mean raw scores or age equivalence results on either set of subtests. The youngest group had significantly lower mean visual-motor integration, grasping and age equivalence scores than either of the other age groups (separately for boys and girls).
Conclusion
In a sample of Saudi preschool children, there were no significant gender differences in grasping or visual-motor integration fine motor skills, and age differences seemed to be developmentally appropriate
Loss of PINK1 promotes the expansion of hematopoietic cells via upregulating autophagy
Authors: Yi Zhen-Ni , Chen Xiang-Ke , Ma Alvin Chun-Hang
Published: April 2023

PTEN-induced putative kinase 1 (PINK1) is a well-characterized regulator of mitochondrial quality control through mitophagy and its mutations are associated with recessive Parkinson’s disease. However, little is known about its functions in normal and malignant hematopoiesis in vertebrates. Here we aim to unravel the roles of PINK1 in definitive hematopoiesis and its underlying mechanisms using zebrafish (Danio rerio). In this study, we utilized CRISPR/Cas9 system to generate pink1 knockout zebrafish model and PINK1-deficient leukemia cell line. We found that pink1 deficiency activated autophagy in hematopoietic cells and promoted definitive hematopoiesis in zebrafish embryos, which can be alleviated by canonical autophagy inhibition. Further, the proteomic and metabolic analysis revealed an elevated expression of cell proliferation markers and enhanced respiration in pink1-deficient zebrafish embryos. On the other hand, PINK1 deficiency also induced autophagy and cell proliferation in human leukemic cells. Therefore, our findings demonstrated that PINK1 functions as a negative regulator of normal and malignant hematopoiesis through the autophagy-mediated pathway.
Distribution and Frequency of Parotid Gland Tumors in the Anhui Province: A Retrospective Multicenter Study of 758 Cases
Authors: Yin Xinghong , Liu Yehai , Duan Maoli
Published: April 2023

Background: Parotid gland tumors are rare with complex histopathology and no early clinical symptoms. There are no reports of epidemiological and pathological features of parotid gland tumors in the Anhui province of China. We aimed to retrospectively analyze the distribution and histopathological characteristics of parotid gland tumors in the Anhui province.
Methods: We analyzed clinical data of 758 patients with parotid gland tumors who were admitted to three hospital centers between January 2018 and January 2022.
Results: The most frequent neoplasms were pleomorphic adenoma and mucoepidermoid carcinoma. There were 641 patients with benign tumors and 117 with malignant tumors. The most common benign tumors were pleomorphic adenoma, and the most frequent malignant tumor was mucoepidermoid carcinoma. Warthin tumor was the second most common benign tumor. In Hefei, squamous cell carcinoma was the second most common malignant tumor, which is inconsistent with other literature.
Conclusions: The distribution and frequency of most parotid gland neoplasms in the Anhui province were similar to those described worldwide. The historically significant male predilection of the Warthin tumor was confirmed. Future multicenter studies can serve as an epidemiological baseline to better characterize these tumors.
Case-control study on IL-1RAcP rs16865597 gene polymorphism and susceptibility to essential hypertension in a Chinese Han population
Authors: Wu Fangqin , Liu Dongchen , Xia Xin , Yang Xinlei , Huang Suli , Jiang Xinghua , Li Lu
Published: April 2023

Background
Essential hypertension (EH) is a complex cardiovascular disorder involving multiple genetic and environmental factors. The IL-33/ST2 pathway was originally identified as a key player in type 2 immunity, which is involved in EH development. The current study was established to explore the relationship between EH and genetic variants within the IL-33/ST2 pathway in the Chinese Han population.
Methods
1151 EH patients and 1135 controls were enrolled in this study. Sixteen single nucleotide polymorphisms (SNPs) in IL-33 and IL-1RAcP genes were genotyped using the Sequenom MassArray and TaqMan assay. Genotype and allele frequencies were compared between the patients and controls using logistic regression analysis.
Results
Our results demonstrated that the SNP rs16865597 in IL-1RAcP gene was associated with EH risk, where the number of C alleles of rs16865597 negatively correlated with EH susceptibility in both the additive model (P = 0.014, OR = 0.75, 95% CI = 0.59–0.94) and the recessive model (P = 0.011, OR = 0.72, 95% CI = 0.56–0.93). In addition, rs16865597 was associated with decreased EH risk in males (OR add = 0.73, 95% CI = 0.56–0.94, P = 0.015), nonsmokers (OR add = 0.72, 95% CI = 0.54–0.96, P = 0.023), nondrinkers (ORadd = 0.70, 95% CI = 0.53–0.93, P = 0.013), and those with low BMI (OR add = 0.69, 95% CI = 0.51–0.92, P = 0.013).
Conclusion
We identified an EH associated genetic polymorphism rs16865597. Our study might provide a clue to identify potential causal factors in the development of EH.
Tropical and Subtropical South American Intraseasonal Variability: A Normal-Mode Approach
Authors: Mayta Victor C , Teruya Andre , Raphaldini Breno , Dias Pedro Silva , Sapucci Camila
Published: April 2023

Instead of using the traditional space-time Fourier analysis of filtered specific atmospheric fields, a normal-mode decomposition method is used to analyze the South American intraseasonal variability (ISV). Intraseasonal variability is examined separately in the 30-90-day band, 20-30-day band, and 10-20-day band. The most characteristic structure in the intraseasonal time-scale, in the three bands, is the dipole-like of convection between the South Atlantic Convergence Zone (SACZ) and the central-east South America (CESA) region. In the 30-90-day band, the convective and circulation patterns are modulated by the large-scale Madden-Julian Oscillation (MJO). In the 20-30-days and 10-20-day bands, the convection structures are primarily controlled by extratropical Rossby wave trains. The normal-mode decomposition of reanalysis data based on 30-90-day, 20-30-day, and 10-20-day ISV show that the tropospheric circulation and CESA--SACZ convective structure observed over South America are dominated by rotational modes (i.e., Rossby waves, mixed Rossby-gravity waves). A considerable portion of the 30-90-day ISV has also been associated with the inertio-gravity (IGW) modes (e.g., Kelvin waves), prevailing mainly during the austral rainy season.The proposed decomposition methodology demonstrated that a realistic circulation can be reproduced, giving a powerful tool for diagnosing and studying the dynamics of waves and the interactions between them in terms of their ability to provide causal accounts of the features seen in observations.
The Sense of Coherence scale (SOC-13): Psychometric properties in the Czech adult population and general recommendations for the advancement of the scale
Authors: Tušl Martin , Šípová Ivana , Máčel Martin , Cetkovská Kristýna , Bauer Georg Friedrich
Published: April 2023

Our study examines the psychometric properties of the short version of the Sense of Coherence scale (SOC-13) in a representative sample of the Czech adults (N = 498). In the introduction, we describe the general characteristics of the scale summarizing existing evidence about its psychometric properties in other populations and provide a brief overview of SOC-related research in the Czech Republic. We then examine the factorial structure of the SOC-13 and SOC-12 scales using confirmatory factor analysis. Further, we examine the differences in SOC-13 based on sociodemographic characteristics, and we test the convergent validity of the scale using the short form of the mental health continuum scale as a positive mental health outcome and the general anxiety disorder scale as a negative mental health outcome. SOC-13 showed an acceptable fit for a second order three-dimensional model with a specified residual covariance between items 2 and 3. SOC-12 showed an acceptable fit for a one-dimensional model and a second order three-dimensional model. SOC-12 models were superior to SOC-13. Based on our results and on the existing evidence, we make general recommendations for future advancement of the SOC addressing the heterogeneity in the formulation of the SOC items. Specifically, we recommend transforming the SOC scale into an inventory so that all items are formulated as statements rather than a mix of questions and statements. Further, we recommend using a single Likert-type scale response anchor with ascending format rather than multiple response anchors with altering regular and reverse-coded format. We apply our recommendations to the full SOC-29 scale and we provide its English and Czech versions to the researchers for further use and testing.
Non-volatile reconfigurable magnetic domain logic gates in a two-channel hall bar by spin-orbit torque current and read current direction
Authors: Hong JinPyo , Shin Jeonghun , Seo JeongWoo , Song SaeGyoung
Published: April 2023

A long-standing goal of CMOS-based logic devices is to meet the needs of key markets, including ultralow-power operation, suitable scalability, and extremely high operation speed, along with the continuing miniaturization of the architecture. However, despite significant progress in their development, conventional CMOS-based devices still suffer from drawbacks such as introducing large unintended leakage currents and volatile behavior. Thus, reconfigurable logic gates based on magnetic domains (MD) have emerged as a highly promising option because they offer fast operation speeds, nonvolatility, and diverse logic functions in a single-device configuration. Here, we address multiple reconfigurable MD logic gates in a single two-channel Hall bar device by varying the voltage-driven read-current directions in W/CoFeB/MgO/Ta stacks. The nonvolatile MD switching behavior induced by spin–orbit torque (SOT)-driven spin currents significantly affects our logic gate functions, which are not necessarily synchronized to a single clock. By adapting diverse circuit connections and anomalous Hall voltage outputs, we identified eight reconfigurable logic gates, including AND, NAND, NOR, OR, INH, Converse INH, Converse IMP, and IMP, in a single device. Thus, these experimental findings represent a significant step forward in a wide range of spin-logic applications in the near future.
Reproductive behaviors, socioeconomic status and risk for postpartum depression: A Mendelian randomization study
Authors: Han xinyu , wu tianqiang , Feng xiaoling
Published: April 2023

Background
There is a growing body of evidence showing an association between women's reproductive behavior (RB) and socio-economic status (SES) with the incidence of postpartum depression (PPD). However, the causal relationship between these factors and PPD remains unclear. To facilitate timely screening and effective prevention of maternal emotional disorders, we conducted a Mendelian randomization (MR) study to assess causality between RB/SES and PPD. This study aims to provide new insights into the etiology of PPD and inform public health strategies for its prevention and management.
Methods
A two-sample Mendelian randomization (MR) study was conducted to investigate the causal effects of reproductive behavior (RB) and socio-economic status (SES) on postpartum depression (PPD). Strongly associated genetic variants for each phenotype were selected as instrumental variables using a predetermined threshold. The primary analysis was conducted using inverse variance weighted method, with additional MR methods including MR-Egger, weighted median, and weighted mode estimate. Potential pleiotropy of instrumental variables (IVs) was evaluated using the MR pleiotropy residual sum and outlier (MR-PRESSO) test and MR-Egger regression methods, and outliers were identified by MR-PRESSO. Heterogeneity among IVs was assessed using Cochran's Q statistic. Leave-one-out sensitivity analysis was performed to identify SNPs that significantly impacted the results. This study aims to provide a better understanding of the causal relationship between RB/SES and PPD and inform future prevention and intervention strategies.
Result
We found a statistically significant association between age of first sexual intercourse , age at first birth, lifetime number of sexual partners, age completed full-time education, Townsend deprivation index at recruitment, and PPD. However, after Bonferroni correction, only earlier age of first sexual intercourse and age completed full-time education remained significantly associated with an increased risk of PPD. These results were reliable and stable and sensitivity analysis showed no violation of the MR assumptions. This study provides important insights into the causal relationship between RB and SES on PPD and highlights the need for targeted interventions to address risk factors for PPD.
Conclusions.
MR study provides robust evidence that SES/RB play broad impacts on PPD.
Safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis and cerebral microbleeds
Authors: Zhihui Yu , Jun Ma , Ke Shen , Jianguang Chen
Published: April 2023

Background: Intracranial atherosclerotic stenosis (ICAS) is one of the important causes of occurrence and recurrence of ischemic stroke worldwide. Combined antiplatelet therapy may increase the risk of intracerebral hemorrhage, especially in patients with intracerebral microhemorrhage,Objective The aim of this study is to investigate the safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) and cerebral microbleeds(CMBs).
Methods and Results: 305 patients with sICAS were divided into two groups: 215 patients without CMBs and 90 patients with CMBs. All patients were treated with dual antibody therapy for 3 months according to the existing treatment, and were followed up for half a year. The NIHSS and modified Rankin score (mRS) before and after treatment were compared between the two groups, and the incidence of adverse reactions and bleeding conversion were observed. At the same time, the two groups were compared. Moderate to severe CMBs (>6) increased the risk of bleeding in sICAS.
Conclusion For patients with sICAS, it is necessary to conduct head MRI SWI sequence examination to screen out high load CMBs.
Extreme Partitioning of Relic and Contemporary Waters in Arid Environments
Authors: Moran Brendan , Boutt David , Munk LeeAnn , Fisher Joshua
Published: April 2023

Deciphering the dominant controls on groundwater-surface water-climate connections is critical to understanding water cycles in arid environments, yet persistent uncertainties remain. The growing demand for critical minerals such as lithium and associated water demands has amplified the urgency to address these unknowns. We present an integrated hydrological analysis of the Dry Andes utilizing a uniquely large and comprehensive set of tracer data (3H, 18O/2H) and physical observations. We find two strongly decoupled hydrological systems which interact only under specific hydrogeological conditions where preferential conduits have developed. These conduits which efficiently transport contemporary water (wks to yrs old) in the system control the interplay between modern hydroclimate variations and groundwater aquifers. Contemporary waters account for a small portion of basin budgets but are critical to sustaining surface waters, as a result, these systems are sensitive to short-term climate and anthropogenic perturbations. This framework describes a new understanding of dominant controls on natural water cycles intrinsic to these arid mountain systems.
Formation mechanisms, interrelationships, and effects of cognitive factors on diet and physical activity during the post-bariatric surgery period: a cross-sectional study based on compensatory carry-over action model
Authors: Zhao Kang , Zhu Hanfei , Huang Lidong , Yang Ningli , Othman Saleh Mohammed Alhaj , Shi Wenbing , Hua Hongxia , Liang Hui , Xu Qin
Published: April 2023

Background Diet and physical activity (PA) are the two most important behaviors to control energy balance after bariatric surgery, post-bariatric patients need dual behavioral management, and these behaviors are jointly affected by various cognitive factors. This study applied compensatory carry-over action model (CCAM) to investigate the effects of cognitive factors on behaviors, and the effects of behaviors on subjective health outcomes.
Methods This cross-sectional study was conducted among patients at the third month after bariatric surgery in China. We collected patients’ data of status of diet and PA, behavioral cognitive factors (intention, self-efficacy, compensatory belief, transfer cognition), and subjective health outcomes (perceived stress, well-being, quality of life). Structural equation model (SEM) were established to test the hypotheses in CCAM and the mediation relationships.
Results A total of 239 patients data were collected. The results of SEM analysis showed: (1) Among the antecedent cognitive factors, only compensatory belief had a significant effect on diet (P<0.001). (2) Both intention and self-efficacy formed direct associations with their corresponding behaviors, compensatory belief exerted significant effects on intention, transfer cognition exerted significant effects on self-efficacy(P<0.05), which were consistent with the original hypotheses in CCAM. (3) PA demonstrated significant influence only on perceived stress (P=0.004), diet demonstrated significant effects on all subjective health outcomes (P<0.05). (4) The results of mediation analysis showed intention exerted partial mediating effects on the relationship between compensatory belief and diet and exerted complete mediating effects on the relationship between compensatory belief and PA, self-efficacy exerted complete mediating effects on the relationship between transfer cognition and diet and between transfer cognition and PA.
Conclusion Among the antecedent cognitions, the carry-over effect of transfer cognition did not directly affect the behaviors, and interventions should mainly focus on improventment of diet through inhibition of compensatory belief. The associations between behaviors and subjective health outcomes showed that diet exerted more critical effects on the overall health than PA. Overall, based on the analysis of CCAM and from the perspective of joint promotion of behaviors after bariatric surgery, dietary intervention had a higher priority than PA intervention.
Correlation analysis of lumbar disc herniation with lumbar lordosis, intervertebral angle and lumbosacral angle in young patients
Authors: Zhan Zihao , Li Ran , Fu Dongming , Han Hao , Meng Bin
Published: April 2023

Background: It is generally believed that lumbar disc herniation is more common in the elderly population. But with the continuous change of life and working style, more and more young people are suffering from lumbar disc herniation due to their long hours at the desk and poor posture.
Purpuse: To analyze the characteristics of lumbar lordosis (LL), intervertebral angle (IVA) and lumbosacral angle (LSA) in young patients with low back pain and their relationship with lumbar disc herniation.
Material and Methods: 148 young patients with low back pain underwent lumbar magnetic resonance (MR) and digital radiography (DR). According to the results, they were divided into non-lumbar disc herniation group (NLDH group) and lumbar disc herniation group (LDH group). LL, IVA and LSA were measured on the lateral plainradiographs. Then we compare and analyze the characteristics of LL, IVA and LSA of the two groups and their relationship with lumbar disc herniation.
Results: In both groups, IVA gradually increased from L1-L2 to L5-S1, and it reached the maximum at L5-S1. IVA of each segment and the mean LL in LDH group were both smaller than those in NLDH group, but the mean LSA was larger in LDH group, and the differences were all statistically significant (P<0.05). Lumbar disc herniation was negatively correlated with IVA from L1-L2 to L5-S1 and LL, but positively correlated with LSA. Young patients with lower LL and IVA and higher LSA are more likely to develop lumbar disc herniation.
Conclusion: LL, IVA and LSA measured on the lateral plain radiographs can be used as important reference indexes to reflect the condition of lumbar disc herniation.
Position Dependent Formula for the Effect of Opening in Infilled Frame
Authors: Tabeshpour Mohammad Reza , Arasteh Arash Mahdipour
Published: April 2023

Infills can have both positive and negative effects on structures. If designers neglect infills in their design, they may face problems such as over-designing of the main elements of the structure due to not utilizing the stiffness and strength of infills. Moreover, problems like soft-story or short-columns may occur during an earthquake. There are several equations available for calculating the effects of infill stiffness. This article aims to calculate the reduction factor in stiffness when there is an opening in the infill. Furthermore, the present paper considers various parameters that can affect the reduction factor, which have not been addressed by many researchers. These parameters include the location, area, width, and height of the opening, as well as the frame section. For this reason, over 500 different models were analyzed, each varying in at least one parameter from the others. Based on these models, a new formula for calculating the reduction factor of stiffness in perforated infills is introduced. This new formula is more precise and comprehensive than the previous formulas.
Impact of urban‒rural medical insurance integration on the health of the elderly: Evidence from China
Authors: Zhao Jianguo , Liu Ziqiong
Published: April 2023

Background
As the aging population continues to grow at an accelerating pace, it is crucial to pay attention to the impact of public medical insurance policies on the health of older adults. Therefore, based on the health status of older adults in China, we aim to evaluate the effectiveness of the implementation of the integrated policy of urban and rural medical insurance in China.
Methods
Data were obtained from China Health and Retirement Longitudinal Study (CHARLS) of 2015and 2018. we use the difference-in-differences model (DID) to investigate the impact of the urban‒rural medical insurance integration policy on the health status of elderly individuals, we further use Propensity score matching method-difference-in-differences (PSM-DID) and individual fixed effect method to conduct robustness checks on the benchmark regression results.
Results
The results indicate that the urban‒rural medical insurance integration policy effectively improved the health status of elderly individuals. Heterogeneity analysis confirms that the health promotion effect brought about by the urban-rural medical insurance integration policy is more significant among elderly individuals with chronic diseases, higher age and lower education levels. Furthermore, The mechanism test reveals that the implementation of the urban‒rural medical insurance integration policy can effectively improve the medical satisfaction of elderly individuals, which in turn benefits the health of elderly individuals.
Conclusion
The implementation of the integrated policy of urban and rural medical insurance has a significant positive effect on the health status of older adults, particularly for the vulnerable elderly population. This finding indicates that there is still room for further optimization of the current basic medical insurance policies and the level of medical security in China.
Icariside II targets in vitro MAPK and PI3K/Akt signaling in human nasopharyngeal carcinoma cells to induce apoptotic death and suppress proliferation
Authors: XIE Mao , TANG Shengping , LIAO Shijie , LIU Fangxian , WANG Renjun , GUO Zhaoliang , TAN Songhua , TANG Anzhou , LIU Yun , HE Guangyao
Published: April 2023

Background
Icariside II is a derivative of Herba Epimedii, which is a traditional Chinese medicine. While prior reports have demonstrated that this flavonoid exerts a diverse array of antitumor activities when used to treat different human tumor cells, its impact on nasopharyngeal carcinoma (NPC) cells remains to be rigorously investigated.
Methods
In this study, MTT assays and flow cytometry were used to examine the impact of icariside II treatment on the proliferative and apoptotic activity of NPC cells in vitro. In addition, changes in MAPK and PI3K/Akt pathway activation were examined via qPCR and Western immunoblotting.
Results
Together, these analyses suggested that icariside II was able to markedly suppress NPC proliferation in a dose- and time-dependent fashion. Mechanistically, exposure to this flavonoid promoted the apoptotic death of the CNE1 and CNE2 cell lines through the simultaneous downregulation of Bcl-2 and the upregulation of Bax. In addition, icariside II suppress ERK1/2 and Akt phosphorylation while enhancing p38 phosphorylation.
Conclusions
As such, icariside II is capable of inhibiting NPC cell proliferation and inducing apoptotic death at least in part by modulating MAPK and PI3K/Akt signaling.
Traditional pattern enhancement based on improved singular value decomposition and gamma function in the frequency domain
Authors: Dong Yingda , He Chunguang , Yuan Yunmei , yan Yanping , Gao Fan , Wang Ximing , Duo hua
Published: April 2023

Aiming at the problems of blurring and distortion of traditional patterns, an enhancement method to improve resolution and contrast is proposed.First, the discrete wavelet transform, stationary wavelet transform, and interpolation algorithm are used to obtain high-resolution images of traditional patterns. Then, the improved singular value matrix coefficients and the reconstructed gamma function are used to enhance the image contrast to obtain high-resolution and contrast-enhanced patterns. The experimental results show that the evaluation indexes such as mean square error, peak signal-to-noise ratio, and structural similarity corresponding to this method are improved compared with other comparison methods. It can effectively improve the quality of traditional patterns and is of great significance to the research on the restoration and protection of traditional patterns.
Association of lysophosphatidic acid molecules with liver fibrosis – different roles indicated
Authors: Tobita Hiroshi , Sakai Hiromichi , Yamaguchi Akane , Notsu Yoshitomo , Kataoka Masatoshi , Yazaki Tomotaka , Nabika Toru , Ishihara Shunji , Kobayashi Hironori
Published: April 2023

Aim: Lysophosphatidic acid (LPA), which is produced by autotaxin (ATX) known as a marker of liver fibrosis, is a member of the group of lysophospholipids that function as extracellular mediators to activate specific G‐protein‐coupled receptors. This lipid is composed of LPA molecules with varied chemical forms that may have different biological roles. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis.
Methods: Forty-six patients affected by various types of liver disease, including 16 with non-alcoholic fatty liver disease, who underwent an ultrasound-guided liver biopsy were recruited for this study. Liver fibrosis was evaluated using histological grading, as well as shear wave velocity (Vs) and serum level of type Ⅳcollagen 7S (T4c7s). Serum levels of LPA molecules were determined using liquid-chromatography tandem mass-spectrometry (LC-MSMS), while ATX in serum was measured by use of an immunoassay.
Results: Total LPA showed a significant positive association with fibrosis severity evaluated based on histological grading, Vs, and T4c7s used as parameters, following adjustment for other confounding factors, including disease type, age, gender, body mass index, and high-sensitivity C-reactive protein. This association was replicated when 16:0-LPA was substituted for total LPA. In contrast, when 20:4-LPA was substituted for total LPA, no significant association with liver fibrosis was observed. Additionally, 20:4-LPA did not demonstrate a significant correlation with serum ATX, in contrast to 16:0-LPA as well as total LPA.
Conclusions: Although total LPA concentration was shown to be associated with liver fibrosis, the degree of association varied among the different LPA molecule chemical forms, suggesting different pathophysiological roles of individual LPA molecules. The present findings indicate the importance of analyzing individual LPA molecules for determination of association with liver fibrosis and the usefulness of LC-MSMS for that purpose.