bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMULATION AND IN VITRO EVALUATION OF MIRABEGRON EXTENDED RELEASE TABLETS
Authors: Kumar V. Suresh , Munija P. , Tejaswini A.
Published: December 2023

IN the present study extended-release tablets of Mirabegron were successfully prepared by using various polymers likeHPMC K 100M, carbopol 940, and xanthan gum by “direct compression method. Based on the pre-formulation studiesfor drug excipients, compatibility was observed and there were no compatibility problems with the excipients used in thestudy. Evaluation parameters like weight variations friability, hardness, thickness, and drug content were found to bewithin the limits. Among all the developed formulations F7 was selected as the best formulation, [XR (OR) ER]formulations have the longer period of time when compared with other formulations. The drug in zero order modelbased on the pharmacokinetics, extended-release formulation suitable for drug concentration at steady state, isdetermined by elimination half-life & dosing interval. The drug with short half-lives with a clear relationship between theconcentration & response indicate decreasing toxicity by slowing drug absorption therapeutic compounds with short halflives.These are excellent candidates for extended-release preparation because these can decrease dose frequency.
PREVALENCE AND CURRENT TREATMENT STANDARDS IN THE MANAGEMENT OF DISTURBED FUNCTION OF THE PANCREAS - A PHYSICIAN-BASED CROSS-SECTIONAL
Authors: Hariharan M. , Shankar B. Ravi , Pal Sandip
Published: December 2023

Acute pancreatitis (AP), chronic pancreatitis (CP) and cystic fibrosis are frequent causes of disturbed function of thepancreas. Currently, there is insufficient data on the prevalence of disturbed function of the pancreas and its managementwith pancreatic enzyme replacement therapy in Indian clinical practice. A questionnaire-based survey was conductedacross 8 Indian cities involving 63 gastroenterologists who provided their opinions by completing 30-question surveyforms based on their experience with treating 15 patients each with disturbed function of the pancreas. Data werecollected, compiled, analyzed, and presented as frequency and percentage of physicians. According to 50% of thegastroenterologists, 5%-15% of patients presented with symptoms of disturbed pancreatic function every month in theirclinical practice, with common symptoms being abdominal pain (61.9%) and indigestion (38.1%). Pancreatic enzymereplacement therapy (PERT) was the most preferred treatment with 87.3% of specialists recommending it. Acombination of amylase, protease, and lipase was prescribed for patients with symptoms like steatorrhea, indigestion, andabdominal pain by 30.2%, 27.0%, and 25.4% of gastroenterologists, respectively, with 46.0% of the specialistsprescribing them for an average duration of 4-12 weeks. Most gastroenterologists (65.1%) opined that 15,000 units oflipase dosing were very beneficial as compared to 10,000 units. In conclusion, findings from this survey indicate that acombination of amylase, protease, and lipase may be beneficial in patients with disturbed function of the pancreas,especially in those with symptoms of steatorrhea or indigestion; nevertheless, counseling, diet, economic assistance,lifestyle modification, and regular follow-up of patients are warranted.
PREPARATION AND QUALITY EVALUATION OF A POLYHERBAL FORMULATION: KARKATI BEEJ CHURNA.
Authors: Dalal Ketaki Pravin
Published: December 2023

Herbal medicines, made up of different plants materials are used world wide to treat various disorders and are widely accepted by large number of population. But due to climatic changes and lack of knowledge w.r.t identification and preparation of the drugs, it is essential that quality evaluation of herbal medicines must be carried out to manifest the drug as potent and safe. Karkatibeej churna is an ayurvedic herbal formulation which is used in the treatment of urinary disorders. The present study focusses on the quality evaluation of Karkati beej churna w.r.t. parameters like organoleptic chracteristics, physicochemical parameters, microscopic evaluation, phytochemical screening and chromatographic profiling. A Thin layer chromatographic profile was obtained for saponins as saponins are considered as one of the plant diuretics. The results thus obtained for all the above mentioned parameters can be used for future references.
AN OBSERVATIONAL STUDY ON CLINICAL SAFETY AND EFFICACY OF ANTIVIRAL MEDICATIONS USED IN CHRONIC HEPATITIS-B VIRUS INFECTION
Authors: Anusha Aakula , Balaji K. , Chandana Asawar Sai , Sri Bandaripalli Navya , K.N. Chandan Kumar
Published: December 2023

Hepatitis B is serious liver illness that is brought on by hepatitis B virus. It is classified into two types- acute and chronic hepatitis. Antivirals are the best choice of treatment for Hepatitis-B. Tenofovir (25mg and 300mg) and Entecavir (0.5mg) are currently used medications to control viral replication and suppress viral DNA levels. The study was a single centered, observational study that included 60 chronic hepatitis-B patients. They were split into two groups of patients prescribed with Tenofovir and Entecavir. Our study was conducted on 60 patients out of which 81.66% were found to be males and 18.33% were found to be females. Among them, most of the patients belonged to the age group 41-60 years (51.66%). In 51 patients taking Tenofovir monotherapy, 41 patients (80.40%) were having ≤2000 IU/mL. In 6 patients taking Entecavir monotherapy, 3 patients (50%) were having ≤2000 IU/mL. In 3 patients taking Dual therapy, 2 patients (66.67%) were having ≤2000 IU/mL. Among 60 patients, ADRs were reported in 41 patients (68.33%). Commonly reported ADRs were weakness, headache, dizziness, abdominal pain. These are mild and occasional. 73.40% patients reported ADRs while using Tenofovir and 83.33% patients reported ADRs while using Entecavir.

From our study, it was observed that Tenofovir is having good safety and efficacy (80.40%) whereas Entecavir is having 50% efficacy. Tenofovir safety and efficacy is much more when compared to safety and efficacy of Entecavir.
SIGNIFICANCE OF EARLY DIAGNOSIS OF PSYCHIATRIC DISORDERS IN SLEEP APNEA PATIENTS
Authors: Banerjee Anwesha , Pandya Divya , Maitra Arpita , Basu Snehasish , Rao Ashish , Dausage Priyanka
Published: December 2023

Obstructive Sleep Apnea (OSA) is a debilitating condition stemming from disruption to the respiratory system during sleep. At present, the nature of the relationship between OSA and mood, specifically depression and anxiety, is still unclear. The purpose of this paper is to shed some light on this relationship. There is an urgent need to better understand the roles of psychological illness in OSA. Well-designed longitudinal studies are needed to examine temporal  relationships between the OSA, and psychological diseases and further research is needed to establish the role of confounders, and effect modifiers such as gender, in any apparent relationship. Sleep clinicians are advised to consider psychological diseases a likely cause of sleepiness and fatigue. Several possible causal mechanisms linking OSA, and depression have been proposed but not established. Patients who have depression as well as OSA appear worse off than those with OSA only, and depressive symptoms persist in at least some patients in short term studies of treatment forOSA. Direct treatment of psychological diseases in OSA might improve acceptance of therapy, reduce sleepiness, and fatigue and improve quality of life, but intervention trials are required to answer this question.
HISTOPATHOLOGICAL EFFECT OF CHLORPYRIFOS PESTICIDE ON LIVER AND KIDNEY OF FRESH WATER FISH CATLA CATLA
Authors: Rani K. Usha
Published: December 2023

All the natural water bodies are continuously being contaminated with toxic chemicals from industrial, agricultural and domestic activities. Chlorpyrifos is one of the most widely used organophosphate pesticides. Excessive application of pesticides from agricultural fields contaminate aquatic medium, resulting in serious damage to non-target species, including fish. The fish as a bioindicator of aquatic medium plays an important role in the monitoring of water pollution. Histopathology is an important tool for evaluating the action of any toxicant at tissue level. The focus of the present study is to measure the histological changes in liver and kidney of the fresh water fish Catla catla exposed to sub lethal concentrations of chlorpyrifos 1/15th of the 96 hour LC50 values for the period of 10 and 20 days. The fish exposed to chlorpyrifos showed mild vacuolar hepatocytes, dilation of central vein, vaculor degenerative changes, mild hyperaemia and severe hyperaemia of central vein in the liver tissue slide. The changes observed in kidney slide due to the impact of chlorpyrifos toxicity are hemorrhage, degenerative changes in between tubules, constriction of primary tubule, vacuolardegenerative changes, necrosis in epithelial lining of proximal tubules, chlorpyrifos compound induced.
Justification of the conservative treatment of intestinal intussusception in children without age and disease duration considerations
Authors: Karaseva O. V. , Golikov Denis Е. , Kharitonova A. Y. , Gorelik A. L. , Timofeeva A. V. , Frolov E. A. , Lukyanov V. I.
Published: December 2023

Introduction. Since the middle of the last century, the conservative treatment of ileocecal intussusception (ICI) has dominated in children. However, questions on choosing a technique for conservative treatment and indications for surgical treatment remain open.
Purpose. To assess the effectiveness of hydroechocolonoscopy (HEC) for ICI in children regardless of their age and disease duration.
Material and methods. 160 children with confirmed ICI were enrolled in the study. All children, who had developed uncomplicated ICI for the first time, had HEC regardless of their age and disease duration. Failed hydrostatic disinvagination and disease relapse after HEC were indications for surgical management (laparoscopy, colonoscopy, laparotomy). To evaluate the effectiveness of conservative treatment at different age groups and at different terms of disease duration, two comparable trials were performed: 1 – stratification of patients by age: main group (n=130) - children older than one year, comparison group (n=30) – children younger than one year; 2 – stratification of patients by disease duration: main group (n=107) – more than 12 hours, comparison group (n=53) – up to 12 hours. To assess outcomes, the following parameters were analyzed: HEC effectiveness and complications, incidence of early relapses after HEC, causes of HEC failure and relapses after HEC, frequency and surgical techniques applied for treating ICI.
Results. In the groups stratified by age, HEC effectiveness was 95.4% in the main group and 93.3% in the comparison group, p=0.216. Early relapses occurred in 10.3% in the main group and in 3.3% in the comparison group, p=0.128. In the groups stratified by the disease duration, HEC effectiveness was 93.5% in the main group and 98.1% in the comparison group, p=0.204. Early relapses occurred in 10.3% (11) in the main group and in 11.3% (6) of cases in the comparison group, p=0.841. There were no any complications during HEC procedure. Basic reasons for the conservative treatment failure were anatomical ones; for relapses – lymphoid hyperplasia of the abdominal cavity and anatomical reasons. Thus, HEC was effective in 95% of cases; relapses after HEC amounted up to 10.6%. Surgical interventions ( in 15.6%) were started with laparoscopy; laparoscopic disinvagination was effective in 68% of cases. Colonoscopy after successful laparoscopic disinvagination was performed in 5.6%, conversion to laparotomy was in 5% of the total number of observations.
Conclusion. HEC is a highly effective and safe option for HEC conservative management in children regardless of child’s age and disease duration. Indications for surgical treatment for uncomplicated ICI are hydrostatic disinvagination failure and disease relapse.
A successful thoracoscopic treatment of bilateral congenital false diaphragmal hernia in a newborn
Authors: Akselrov M. A. , Razin Maxim P. , Sergienko T. V. , Sudareva D. I. , Tanzybaev A. V.
Published: December 2023

Introduction. Congenital diaphragmatic hernia (CDH) occurs with frequency of 1:2000 to 1:4000 live births. False CDH are more common. Out of unilateral diaphragm defects, left-sided ones predominate (9–24 times more often depending on hernia type). Bilateral diaphragmatic hernia is an extremely rare malformation which accounts for no more than 1% of all diaphragmatic hernias.
Description of observation. The authors present their own experience in treating a rare clinical case of bilateral false diaphragmatic hernia in a newborn with the left-sided component manifested immediately after the birth and with the right-sided one – in 2 weeks after the correction of the first one, as well as its successful thoracoscopic treatment.
Conclusion. The authors consider that one of the possible reasons for not detecting this pathology at ultrasound examination is translocation of the abdominal organs to the chest (which can occur antenatally, intra- and postnatally).
Laparoscopic treatment of hydronephrosis in children with the horseshoe kidney: description of a case series
Authors: Kozlov Yury A. , Poloyan S. S. , Marchuk A. A. , Rozhanski A. P. , Byrgazov A. A. , Kovalkov K. A. , Ochirov Ch. B. , Kapuller V. M. , Narkevich A. N.
Published: December 2023

Introduction. The present research is a case series of laparoscopic treatment of pyeloureteral obstruction in 3 patients with a horseshoe kidney.
Material and methods. Laparoscopic treatment of hydronephrosis in three patients with the horseshoe kidney was performed by one surgeon (2 boys, 1 girl). Preoperative computed tomography confirmed the diagnosis and found a source of hydronephrosis – obstruction of the pyeloureteral segment. At laparoscopy, the horseshoe kidney anatomy was finally defined and the cause of the obstruction of the pyeloureteral segment was found too - high ureteral transposition from the pelvis or an aberrant vessel. Pyeloplasty performed by Anderson-Hynes technique was a final stage of the treatment.
Results. The lesion of the left kidney half was noted in 2 cases, of the right one – in 1 case. All three interventions were successfully performed laparoscopically without conversion to open surgery. Duration of surgical intervention varied from 60 to 90 minutes. Mean operative time was 75.0±15.0 min (median – 75.0 [67.5; 82.5] min). Average stay in ICU was 19.3±4.2 hours (median – 18.0 [17.0; 21.0] hours) with the longest interval being 24 hours in a younger patient due to tracheal decannulation problems .
The anteroposterior diameter of the pelvis was measured before surgery and 6 months after surgery. It was found that all patients had reduction in the pelvis size in average from 43.3±11.5 mm to 8.0±2.0 mm (median – 50.0 [40.0; 50.0] mm and 8.0 [7.0; 9.0] mm, respectively). Patients also showed a positive trend in the restoration of blood flow in the affected segment of the kidney. Resistance index changes were in averaged from 0.70±0.02 to 0.62±0.02 (median – 0.71 [0.70; 0.72] and 0.62 [0.61; 0.63], respectively).
Conclusion. Surgical treatment of hydronephrosis in patients with the horseshoe kidney is a complex problem, mainly because of the altered renal anatomy and variety of triggers that may cause hydronephrosis. Laparoscopic pyeloplasty is obviously a universal way to treat the discussed pathology.
Surgical treatment of multiple bilateral brain abscesses and subdural empyas in a 6-year-old child with purulent rhinosinusitis
Authors: Asadov Ruslan N. , Tekoyev A. R. , Tumanyan L. R. , Indereykin M. V. , Vrublevskaya Е. N. , Krapivkin A. I. , Vrublevskiy S. G. , Romanov P. A. , Prokopev G. G. , Sarafanova M. E.
Published: December 2023

Introduction. Bacterial brain abscesses and subdural empyema are often rare complications of rhinosinusitis, which is especially important in pediatric practice. Intracranial purulent clusters are life-threatening diseases which require urgent, and as a rule, surgical management.
Purpose. To illustrate successful surgical treatment of a patient with multiple bilateral brain abscesses and subdural empyemas as a result of purulent inflammation - paranasal sinusitis, which had not been diagnosed at the prehospital stage.
Material and methods. A case of a 6-year-old boy with multiple bilateral brain abscesses and subdural empyemas is described in the article. The patient had antibacterial therapy; paranasal sinuses were sanitized; all intracranial purulent foci were removed with minimally invasive approaches and accurate calculations based on findings of MRI examination.
Results. It had been confirmed that abscesses and subdural empyemas in the described patient was a complication of purulent inflammation in paranasal sinuses. To control treated foci and to exclude development of new purulent intracranial clusters in dynamics, multiple MRI examinations of the brain were performed. For successful management of purulent foci, the technique of incision, drainage, sanitation with antiseptic solutions and intraoperative exudate aspiration was applied.
Conclusion. Abscesses and empyemas of children’s brain are serious, life-threatening pathologies that always require hospitalization and emergency measures. Multiple abscesses and subdural empyemas is, as a rule, complication of rhinosinusitis. Multiple dynamic CT/MRI examinations of the brain is of a key importance, both for controlling removed foci and for excluding development of new purulent intracranial clusters. Active surgical tactics in the combination with antibacterial therapy leads to successful outcomes in patients with intracranial purulent lesions complicating the course of rhinosinusites.
Assessment of the Impact of Outdoor Classrooms in Environmental Education in Nigeria
Authors: Joy Okah-Tim Elegant
Published: December 2023

This opinion paper examines the impact of outdoor classrooms in environmental education in Nigeria. With the increasing concern about the environment and the need for effective educational approaches, outdoor classrooms have gained popularity as a promising tool for engaging students in hands-on, immersive learning experiences. This paper assesses the advantages and challenges associated with outdoor classrooms and investigates their effectiveness in promoting environmental awareness and stewardship among students. Drawing on empirical studies and expert opinions, it argues that outdoor classrooms provide unique opportunities for students to connect with nature, enhance their understanding of ecological concepts, and develop a sense of responsibility towards the environment. Furthermore, this paper explores the potential barriers to implementing outdoor classrooms, such as logistical constraints and limited resources, and proposes strategies to overcome them. By critically examining the impact and potential of outdoor classrooms in environmental education, this paper aims to promote the adoption and integration of this innovative approach into mainstream educational practices, ultimately fostering a society of environmentally conscious individuals.
A Study on Role of Rural Women of District Anantnag of Kashmir Valley in Natural Resource Management
Authors: Bhat Bilal Ahmad , Aushiq Samreena
Published: December 2023

A natural resource is a material that comes from the natural environment and in its raw or “natural” state is of value for support and sustenance of life on earth with its ecological value and diverse resources. The natural resource management is the taking care of natural resources like land, water. It has been noticed that use and abuse of natural resources is a key issue that has been caused by mankind. The misuse of natural resources directly or indirectly refers to excessive use, destructive use or achieving imbalance between natural resources either individually or in combination. The purpose of current study was to investigate the role of Rural women in natural resources management and utilization in Anantnag, J&K. The role of women in natural resource management is crucial for sustainable development. This abstract explores the multifaceted contributions of women of this domain, including their roles as farmers, forest users, and water managers women”s local knowledge and expertise often lead to effective resource conservation and community resilience .Despite their significant contributions ,women often face barriers such as limited access to resources and decision making power and empowering women in natural resource management can enhance conservation efforts and promote equitable and inclusive development. In the current study quantitative as well as qualitative data was collected from 100 rural women selected at random using simple random sampling technique. The data collected were analyzed using appropriate statistical tools. The study revealed that the respondents understudy in majority have limited access of latest technology, skill training, education, extension services and current information. In order to strengthen the women’s participation in resources management and sustainable uses, the researchers suggest that suitable measures should be taken to empower women in decision making, skill training, education and extension activities.
Can Governments Still Get Things Done?
Authors: de Winter Paulien , Winter Heinrich
Published: December 2023

Can governments still get things done?

Governments seem to be struggling in a high-tech and at the same time fragmenting society. Think, for example, of the Child Care Benefit Scandal in the Netherlands. In this special issue the central question is “Can governments still get things done?” Different paradigms can be distinguished around government and governance: bureaucracy, new public management and public value. In studying the central question, three perspectives are distinguished: macro, meso and micro. The different contributions to this special issue cover various phases in the policy process. This special issue shows a shift from general arrangements to tailor-made solutions and from screen bureaucracy to a more human-sized approach. It also illustrates the importance of recognizing system characteristics in cases of policy failure.
Blame or Karma?
Authors: van Thiel Sandra , Migchelbrink Koen
Published: December 2023

Blame or Karma? The attribution of Blame in the Childcare Benefits Affair

The childcare benefits affair refers to a period between 2005 and 2019 in which an estimated 30,000 families were deliberately put into serious financial and personal harm by the tax administration because of often unjustified suspicions of fraudulent behaviour. Inquiries into the political and administrative causes and consequences led to a restructuring of the tax administration and the resignation of the cabinet at the beginning of 2021. By reconstructing the affair, we analyse what role politics and politicians played and how they attempted to avoid blame for the affair. Several strategies were used to avoid blame, including tasking a committee to write a report, restructuring the tax administration and promising swift compensation to the victims. The only party that seems to have avoided blame is parliament, despite multiple indications that members of parliament played an important role in the emergence of the affair.
System failure in the digital welfare state
Authors: Bouwmeester Maarten
Published: December 2023

System failure in the digital welfare state: Exploring parliamentary and judicial control in the Dutch childcare benefits scandal

In recent years, there have been multiple policy fiascos (large-scale policy failures) in the digitalized enforcement of social security across welfare states. Besides similarities in outcomes, these cases have exposed far-reaching consequences of ‘rule of law system weaknesses’ in the form of deficits in parliamentary and judicial control. While there has been increasing attention for the vulnerability of benefit recipients in the digital welfare state, the importance of parliamentary and judicial control and the problematic nature of deficits in these control mechanisms has remained largely overlooked. This article takes a first step towards an understanding of this issue. It (a) examines the linkages between parliamentary and judicial control and policy failure and (b) analyses the role of deficits in these control mechanisms in the Dutch childcare benefits scandal. The results demonstrate the combined relevance of a variety of control deficits related to the legislative process, parliamentary scrutiny and judicial review. Moreover, interdependencies between parliamentary and judicial control highlight the importance of holistically analysing their combined influence. All in all, the article facilitates a deeper understanding of system failure in the digital welfare state and provides recommendations for future research.
The Murky Waters of Algorithmic Profiling
Authors: Haitsma Lucas Michael
Published: December 2023

The Murky Waters of Algorithmic Profiling: Examining discrimination in the digitalized enforcement of social security policy

In the Netherlands, organizations tasked with investigating and sanctioning social security fraud often use algorithmic profiling technologies. Despite the potential benefits, such technologies are not immune to risks, such as discrimination. A lack of clarity in the translation of non-discrimination legislation into practice entails that organizations are tasked with engaging and operationalizing this legislation ex-ante through the identification and mitigation of risks of discrimination. This paper explores the question: How does the use of algorithmic profiling technologies lead to discrimination and can social security organizations mitigate these risks? In order to answer this question, the theoretical framework of the algorithmic lifecycle is used to identify risks of discrimination in the design, implementation, and use of algorithmic profiling technologies. In particular, semi-structured interviews with experts and the Dutch Childcare Benefits Scandal case are used to identify risks of discrimination and examine how they interact to produce discriminatory outcomes in practice. The findings demonstrate that discrimination is the result of a complex interaction of unmitigated risks throughout the algorithmic lifecycle of profiling technologies. This highlights the importance of taking a lifecycle approach to the identification and mitigation of risks of discrimination.
Legal Consciousness and the Implementation of Equality and Human Rights Law in England and Wales
Authors: Barrett David
Published: December 2023

Legal Consciousness and the Implementation of Equality and Human Rights Law in England and Wales

Increasingly, Western governments need not only get things done, but get things done well. In this regard, equality and human rights standards provide a significant framework for governments to improve the quality of their performance. Regulators, inspectorates and ombuds (RIOs) are particularly important in this regard as they are in a privileged position to monitor and assess the implementation of equality and human rights standards by governments. However, as yet, the performance of RIOs has been underwhelming. To investigate this underperformance, this article explores the legal consciousness (i.e. understandings and perceptions of the law) of the individuals responsible for the implementation of equality and human rights laws within a sample of RIOs in England and Wales. Two different types of legal consciousness are identified: law as sacrosanct and law as malleable. The article then explores how these different types of legal consciousness influence implementation. It concludes by highlighting factors that influence an individual’s legal consciousness and ways that these can be enhanced to improve the quality of implementation in the future.
Transitivity in Pope Francis’ Speech in Morocco: A Systemic Functional Linguistic Analysis
Authors: EL Hadifi Mohammed
Published: December 2023

The way we speak and the words we choose to convey a certain message are not neutral. They are overloaded with certain meanings that represent our worldview, namely when delivered by most influential people like religious leaders and used in contexts which are ideologically constructed like that of the speech of Pope Francis with his symbolic power and role in religious diplomacy. The main aim of this study is to investigate the construction of experiential meanings in Pope Francis' historical speech during his apostolic journey to Morocco on March 19, 2019, by examining the specific linguistic choices employed. This study employs the transitivity model within the framework of systemic functional linguistics (SFL) as its theoretical foundation for analysis. Precisely, using quantitative analysis, this paper endeavors to address two key questions: Firstly, what distributions and patterns of transitivity has Pope Francis utilized in constructing experiential meanings in his speech in Morocco? Second, what functions do the transitivity processes and each participant involved have in the delivered speech text, aiding the speaker in conveying their intention? The dataset comprises 182 clauses extracted from the aforementioned speech. The results of this study showed that Pope Francis employed six types of transitivity processes, totaling 186 processes. Yet, material processes, constituting 62%, and mental processes, comprising 15%, were identified as dominant, suggesting their significant roles in conveying vibrant information in his speech that aimed to enhance dialogue and foster friendly relations between Catholicism and Islam, promoting cooperation in the construction and establishment of a world characterized by sincere, courageous, and essential collaboration. The findings therefore indicate that transitivity choices play a crucial role in conveying implicit meanings.
PENGEMBANGAN UMKM PIA“KUE CIPTA RASA”
Authors: Luh Desi Utami  , Gusti Putu Eka Kusuma  , Anak Agung Ngurah Restu Gautama
Published: December 2023

Pia adalah lini usaha bidang industri makanan. UMKM kue cipta rasa ini memproduksi Pia yang diwariskan turun-temurun dan berdiri sejar 1990. Kue cipta rasa ini menjual pia dengan berbagai varian mulai dari rasa kacang ijo, durian dan susu. Kegiatan pengabdian masyarakat ini mengarah pada pengembangan pembuatan Pia cipta rasa. Tujuan dari kegiatan ini adalah memberikan pembinaan dalam aspek pemasaran yaitu memberikan penjelasan pentingnya promosi dalam suatu usaha serta memberikan pembinaan tentang penyusunan laporan keuangan. Adapun kesimpulan yang dapat diuraikan bahwa pembinaan ini menghasilkan benefit berupa pengetahuan bagi pemilik Kue Cipta Rasa yang berorientasi pada pemahaman konsep pemasaran serta keuangan melalui penyusunan laporan keuangan. Adanya program pembinaan UMKM ini melalui aspek pemasaran dan keuangan pemilik usaha kue ipta rasa mulai memisahkan keuangan pribadinya dengan uang usahanya, selain itu sudah mulai mempromosikan produknya melalui media social guna menarik minat konsumen yang mana di harapkan dapat meningkatkan penjualan dari produk pia yang di jual oleh kue cipta rasa.
Efeitos de um programa de intervenção, através da telerreabilitação, para pacientes com dor lombar crônica: um protocolo clínico
Authors: Sarchis Anna Paula Campos , Fonseca Diogo Simões , Freitas Lucas Magalhães de , Mármora Cláudia Helena Cerqueira
Published: December 2023

Introdução: a dor lombar é um dos mais difundidos problemas de saúde pública enfrentados no mundo e, dessa forma, o acesso aos tratamentos baseados em evidências – como educação em neurociência da dor e exercícios terapêuticos – é frequentemente limitado devido a inúmeras barreiras. Objetivo: desenvolver um protocolo de intervenção que utilize um programa estruturado de educação em dor associado ao exercício terapêutico para o tratamento da dor lombar crônica, por meio de telerreabilitação. Método: este protocolo descreve um delineamento experimental do tipo ensaio clínico controlado, aleatorizado com avaliador e estatístico mascarados. Discussão: a hipótese aqui apresentada é a de que o programa de telerreabilitação beneficiará pacientes com dor lombar crônica, reduzindo a intensidade da dor, melhorando a função e fatores psicológicos.
Diferencial de peso de bezerros desmamas Nelore Convencional e Senepol
Authors: Freitas Michel Pedro Vieira de , Costa Caroline Pereira da
Published: December 2023

O agronegócio brasileiro representa uma importante atividade econômica do país, responsável por grande parte da geração de riquezas e se destacando também na geração de emprego e renda (FERRAZZA; CASTELANNI, 2021). As raças abordadas no estudo trazem benefícios importantes para o pecuarista. Se tratando da raça Nelore, conhecida por suas características distintivas, incluindo um rápido ganho de peso, uma notável resistência às doenças, longevidade reprodutiva tanto em machos quanto em fêmeas, excelentes habilidades maternas nas fêmeas, além de produzir carne de alta qualidade, caracterizada por sua baixa quantidade de gordura e um sabor acentuado. Além disso, também é reconhecida por sua carcaça de qualidade (STAMOULIS, 2020). A heterose é a medida da superioridade média da geração F1 em relação à média dos pais, expressa em termos de características como peso ou comprimento. É uma indicação de quão superior é a média da geração F1 em relação à média das raças parentais (ELER, 2015). De acordo com Carvalho (2018), ao utilizar o sistema de cruzamento industrial, é importante levar em consideração diversos fatores. Alguns desses fatores incluem a demanda do mercado, o ambiente em que os animais serão criados, o nível gerencial disponível, a viabilidade do uso de inseminação artificial, o sistema de produção adotado, os objetivos do empreendimento, o número de vacas disponíveis e o tamanho e número de pastos. O cruzamento entre raças emerge como uma alternativa eficaz, rápida e economicamente vantajosa na busca por uma maior produtividade em rebanhos de cria. Essa abordagem se destaca pelos ganhos obtidos através da heterose e complementaridade genética (AZAMBUJA. 2013). Os resultados evidenciam um desempenho superior no lote de cruzamento Senepol em comparação ao lote de Nelore.
Grupos de Lie e Equações de Riccati
Authors: Pinto Alisson da Silva , Da Silva Patrícia Nunes , De Faria Cristiane Oliveira , Dos Santos André Luiz Cordeiro
Published: December 2023

Equações diferenciais são frequentes em diversas áreas do conhecimento. Existem diversas técnicas para encontrar a solução de uma equação diferencial ordinária (EDO). O matemático norueguês Sophus Lie desenvolveu uma teoria que unifica os métodos de solução de EDOs utilizando grupos de simetrias. Tal método consiste em encontrar um grupo de simetrias da EDO e associar a ele um sistema de coordenadas canônicas no qual a EDO é expressa de maneira bastante simples. Após breve apresentação da teoria degrupos de Lie, concluímos apresentando um exemplo com uma EDO de Riccati.
Adjusting Labor Sublease Activities In The Current Labor Code In Vietnam
Authors: Diep Dao Mong
Published: December 2023

Objectives: Research the legal status of labor subleasing and practical implementation in Vietnam, thereby proposing solutions to improve the provisions of the Labor Code on labor subleasing activities in the current period.

 

Legal framework: The legal foundation of this study is based on the provisions of the 2019 Labor Code on labor subleasing and related legal documents.

 

Methodology: The methods used include analysis, synthesis, comparison, statistics, and commentary, combined with a review of legal regulations related to labor subleasing activities. This study also draws on secondary sources, including articles and academic commentaries, to gain a comprehensive understanding of the research topic.

 

Results and conclusions: The study proposes solutions to improve the effectiveness of implementing the law on labor subleasing in Vietnam. The research will be the legal basis for effectively regulating businesses that provide professional services for specific industries, improving business performance in recruiting and training human resources in order to respond to international economic integration. Besides, the research is also the basis for protecting employees in outsourcing businesses. At the same time, it improves the efficiency of state management of subleasing in the current period.
Litigation Guarantees in Fast-Track Lawsuits and One-Session Lawsuits - A Comparative Study
Authors: Flayyih Najlaa , Mallet Pierre , Abdijabar Zeana Ghanim
Published: December 2023

Objective: The UAE legislator has introduced a new mechanism within the judicial system aimed at achieving swift justice and preserving the right to litigation, with:  the objective of resolving cases quickly and fairly, providing reassurance and confidence to all parties involved, and ensuring their rights are secured through the most straightforward and expedited procedures.   Methods: the research methodology is in line with this, the United Arab Emirates has launched a judicial system known as the "One-Day Court," designed to simplify procedures and expedite the resolution of civil cases within a period of up to 15 days. This move is intended to enhance the country's competitiveness on both regional and global levels, with the aim of advancing the development of its legislative and judicial environment.   Result: Despite the effectiveness of the "One-Day Court" and the fast-track approach in achieving its intended goals, there are still challenges associated with various litigation guarantees, particularly those concerning the stages of notification, appeals, litigation at two instances, and maintaining the principle of open court hearings.   Conclusion: As a result, scholars and jurists have been contemplating innovative solutions to strike a balance between the speed and simplicity of procedures on one hand and safeguarding and preserving litigation guarantees on the other.
Environment and Human Health: Beyond Disciplinary Confinement
Authors: Kumari Nisha , Dubey Anubhuti
Published: December 2023

The human health results from the interplay of lifestyle, genetic, psychological, and other factors. In addition, humans are exposed to numerous environmental factors that affect their physical and mental health. In the present piece of work, the impact of environmental exposure on mental and physical health is understood in the broadest sense. The environment has direct and indirect effects on mental and physical health. High-rise housing and other constructions are detrimental to the psychological wellbeing of people. Residential overcrowding, these high-density areas, and noisy exterior noise sources increase psychological distress and may contribute to the development of mental and physical disorders. Air pollutants with a pungent odor amplify negative effects, and environmental pollutants have also been linked to behavioral disturbances. Lack of adequate daylight is reliably associated with melancholic dispositions and increased depressive symptoms. Consequently, environmental factors continue to negatively impact both mental and physical health. The environment has the potential to encourage or inhibit human interaction. Along with this, individuals’ personal control, social support, relationships, and restoration from tension and fatigue may all be affected by various aspects and properties of the built environment. Even during the COVID-19 pandemic, when work from home had become commonplace, environmental factors had a significant impact on the health outcomes of individuals. Hence, this article is trying to shed light on the environmental factors that affect the physical and mental health of its users in more than one way and what can be done to make it less stressful, safer, and better by improving the tangible environment.
Systemic capillary leak syndrome during cardiac surgery
Authors: Fatih Aşgün Halil , Oğuz Sonay
Published: December 2023

Systemic capillary leak syndrome is defined as excessive fluid and protein extravasation caused by microvascular hyperpermeability. It is a very rare condition, and may occur during or after any surgery without preceding symptoms or a suggestive history. It has been reported in pediatric cardiac surgery patients, and is not expected in adults. In this article, we present a 75-year-old female case of severe systemic capillary leak developed during coronary artery bypass grafting combined with dual valve replacement. To the best of our knowledge, this is the first adult case in the literature having an acute attack of systemic capillary leak syndrome during cardiac surgery.
The change of systemic inflammation response index in the treatment of patients with myasthenia gravis undergoing thymectomy: A retrospective, follow-up study
Authors: İlknur Ulugün Fatma , Özdemir Nezih
Published: December 2023

Background: This study aims to investigate the role of neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammation response index in patients with myasthenia gravis, thymomas and thymic hyperplasia and to identify the relationship between the inflammation response and disease activity.

Methods: Between January 2010 and December 2018, a total of 97 patients (71 males, 26 females; mean age: 36.7±16.3 years; range, 15 to 76 years) who underwent extended thymectomy with the diagnosis of myasthenia gravis were retrospectively analyzed. The patients were divided into two groups as the patient group (n=42) and the control group (n=55). Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyteto-lymphocyte ratio, and systemic inflammation response index were measured one day prior to and one month after surgery.

Results: The patients with thymoma were older with a higher mean pre-systemic inflammation response index value. Preoperative systemic inflammation response index, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly higher in patients with thymoma. A preoperative systemic inflammation response index value of less than 0.62 was accepted to indicate thymic hyperplasia and a postoperative systemic inflammation response index value higher than 2.94 was indicative of thymoma. In myasthenic patients whose steroid dose was increased and/or remained the same at the first month after surgery, postoperative monocyte-to-lymphocyte ratio and systemic inflammation response index values were found to be higher compared to preoperative values (p=0.006 and p=0.032, respectively). Patients whose pyridostigmine dose was increased and/or remained the same had significantly higher systemic inflammation response index values postoperatively (p=0.029).

Conclusion: The precise cut-off values of systemic inflammation response index may be helpful for the surgeon to predict the surgical outcome and post-systemic inflammation response index may be a predictive marker for estimating postoperative treatment changes.
ESTUDO SOBRE A OCORRÊNCIA E POTENCIAIS IMPACTOS DE FÁRMACOS NO MEIO AMBIENTE
Authors: Dos Santos Jéssica Torres , Pinheiro Caroline Menezes , Hoss Louise , Schoeler Guilherme Pereira , De Holanda Jéssica da Rocha Alencar Bezerra , Da Silva Julia Kaiane Prates , Mendes Julia , Morselli Luiza Beatriz Gamboa Araújo , Do Carmo Lara Alves Gullo , Quadro Maurizio Silveira , Andreazza Robson , De Escobar Cícero Coelho
Published: December 2023

Uma preocupação atual e emergente tem sido a contaminação de mananciais por resíduos de medicamentos, uma vez que a diversidade de fármacos existentes implica que esta classe de compostos químicos possui diferentes atividades biológicas, que podem ser mantidas mesmo após metabolização e excreção destes compostos para o meio ambiente. O aumento contínuo da presença destes compostos nos mananciais de abastecimento representa uma das problemáticas mundiais do comprometimento da qualidade das águas destinadas para o consumo humano e dos prejuízos inerentes sobre os ambientes aquáticos impactados por estes compostos. Dessa forma, esta revisão de literatura teve como objetivo discutir os conhecimentos sobre a problemática dos fármacos no meio ambiente, através da análise de diferentes trabalhos e estudos de caso que abordam essa temática. A pesquisa caracterizou-se como uma revisão bibliográfica, desenvolvida com base em materiais já elaborados, e tem como objetivo explorar um tema com base em referências teóricas publicadas em livros, revistas científicas, periódicos, entre outros. Na busca, foram definidas palavras-chave de modo a facilitar a procura dos artigos, sendo elas: "pharmaceuticals" AND "environmental"; bem como foi definido o período, conforme o ano de publicação, do ano de 2010 até 2020. Foram selecionados três artigos para compor a revisão bibliográfica deste trabalho. De forma geral, os três estudos selecionados apontam uma emergente preocupação, com diferentes abordagens, a qual é a questão da contaminação do ambiente com fármacos. Os dois primeiros investigam a ocorrência de fármacos em lugares pontuais, enquanto o terceiro, baseado em estudos e relatos destas ocorrências, estabelece uma lista prioritária visando o monitoramento e tratamento destes fármacos encontrados. A partir dos estudos apresentados pode-se perceber que, apesar dos medicamentos possuírem uma função vital e serem imprescindíveis para o tratamento de determinadas enfermidades, a sua ocorrência em esgotos sanitários e águas naturais é um importante tópico internacional. Pode-se concluir que é possível discutir as causas e formas de identificação de medicamentos no ambiente, porém, os efeitos para os organismos ainda são desconhecidos, principalmente quando são tratados ao longo de cadeias tróficas. Portanto, fica evidente a necessidade de mais estudos a fim de diagnosticar a situação dos corpos hídricos ao redor do mundo, bem como a investigação dos seus efeitos nocivos e os sistemas de tratamento, de forma a buscar um gerenciamento mais eficaz dos resíduos de fármacos.
CONTABILIDADE GERENCIAL: A IMPORTÂNCIA DAS FERRAMENTAS DE GESTÃO PARA MICRO E PEQUENAS EMPRESAS
Authors: Soares Brenna de Souza , Guedes Kleber Meireles , Da Fonseca Bruna Silva , Abensur Marcos André
Published: December 2023

O presente artigo tem como objetivo demonstrar a importância das ferramentas da contabilidade gerencial para os gestores, e qual seria a contribuição que elas trariam para a tomada de decisão nas entidades, bem como a necessidade de auxílio nas tomadas de decisões das empresas. Utilizou-se como metodologia para a realização do estudo de caso, através de um questionário e pesquisas bibliográficas em livros e artigos, por meio da qual foram coletados os dados de como essas ferramentas contribuem para a tomada de decisão. Conclui-se assim que a contabilidade gerencial trata de uma base para uma administração de gestão segura, dando informações de qualidade, mostrando como as ferramentas de contabilidade gerencial podem ajudar gestores em seus vários cargos gerenciais, pois permite controlar as atividades da empresa, para que as decisões possam ser tomadas com mais confiabilidade e segurança para que o gestor tenha uma visão mais completa de sua empresa.