bluuebunny/crossref_metadata_2025 huggingface dataset:
When rudeness goes home: the impact of supervisor incivility on employees’ work–family conflict
Authors: Imam Hassan , Bilal Naveed , Sekiguchi Tomoki
Published: January 2025

This study uses the frustration-aggression theory to examine how supervisor incivility relates to employee interpersonal incivility toward customers and co-workers and work–family conflict. Work–family conflict refers to the incompatibility between the demands and responsibilities of an individual’s work role and their family role. Service employees from the banking industry (N = 750) participated in the study’s daily multisource questionnaires over a continuous two-week period. The study’s findings, based on multilevel structural equation modeling, show that supervisors’ hostility toward subordinates increases employee interpersonal deviance toward customers and co-workers, as well as work–family conflict. Additionally, the study found in a parallel mediation that the association between supervisor-initiated incivility and work–family conflict is mediated by employee interpersonal deviance toward co-workers and customers. These findings indicate the detrimental effects of incivility from supervisors on both the workplace and employees’ personal lives. The study suggests that workplace incivility causes a negative spiral of mistreatment where a target of incivility may respond by mistreating other, resulting in a toxic work environment. However, organizations can mitigate the negative effects of incivility and promote productivity and success for employees and organization by investing in employee well-being and creating a respectful work culture.
Measuring STEM Instructors’ Learning of and Growth in Inclusive Teaching: Development and Evaluation of the STEM Faculty Inclusive Teaching Survey (FITS)
Authors: Johnson-Ojeda Vanessa , Hill Lucas B. , Shin SuYeong , York Alessandra M. , Frey Regina F.
Published: January 2025

The Faculty Inclusive Teaching Survey (FITS) was developed and evaluated for STEM higher education. The FITS (awareness and impact of identity, confidence in, reflection on, and likelihood to implement inclusive teaching) can be used as one measurement approach by instructors, departments, and faculty developers to improve inclusive STEM teaching.
First-Line Mobocertinib Versus Platinum-Based Chemotherapy in Patients With
EGFR
Exon 20 Insertion–Positive Metastatic Non–Small Cell Lung Cancer in the Phase III EXCLAIM-2 Trial
Authors: Jänne Pasi A. , Wang Bin-Chao , Cho Byoung Chul , Zhao Jun , Li Juan , Hochmair Maximilian , Peters Solange , Besse Benjamin , Pavlakis Nick , Neal Joel W. , Kato Terufumi , Wu Yi-Long , Nguyen Danny , Lin Junjing , Lin Jianchang , Vranceanu Florin , Szumski Annette , Lin Huamao M. , Fram Robert J. , Mok Tony S.K.
Published: January 2025

PURPOSE

Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets
EGFR
exon 20 insertion (ex20ins) mutations in non–small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier:
NCT04129502
) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of
EGFR
ex20ins+ advanced/metastatic NSCLC.

METHODS

Patients with treatment-naive
EGFR
ex20ins+ locally advanced/metastatic NSCLC were randomly assigned 1:1 to mobocertinib 160 mg once daily or pemetrexed plus cisplatin or carboplatin every 3 weeks for four cycles followed by maintenance pemetrexed. The primary end point was progression-free survival (PFS) by blinded independent central review (BICR), with planned interim analysis (IA) after approximately 70% of 227 expected PFS events.

RESULTS

A total of 354 patients were randomly assigned (mobocertinib: n = 179; chemotherapy: n = 175). Baseline characteristics were balanced between arms. At IA (cutoff: April 4, 2023), the median PFS per BICR was 9.6 months in each treatment arm (hazard ratio [HR], 1.04 [95% CI, 0.77 to 1.39];
P
= .803). The primary end point crossed the prespecified futility boundary (HR > 1). The confirmed objective response rate (95% CI) per BICR was 32% (26 to 40) with mobocertinib versus 30% (24 to 38) with chemotherapy; the median duration of response was 12.0 versus 8.4 months. Quality-of-life assessments indicated clinically meaningful delays in time to deterioration of lung cancer symptoms, cognitive function, and constipation with mobocertinib versus chemotherapy. Grade ≥3 adverse events in >5% of patients (mobocertinib, chemotherapy) were diarrhea (20%, 1%), anemia (6%, 10%), increased lipase (6%, 0%), and decreased neutrophil count (1%, 7%).

CONCLUSION

The EXCLAIM-2 trial did not meet its primary end point. The efficacy of mobocertinib was not superior to platinum-based chemotherapy for first-line treatment of patients with
EGFR
ex20ins+ advanced/metastatic NSCLC.
Natural History of Cytologically Low-Risk Indeterminate Thyroid Nodules
Authors: Teliti Marsida , Chytiris Spyridon , Coperchini Francesca , Cerutti Matteo , Grillini Beatrice , Gallo Maria , Calì Benedetto , Arpa Giovanni , Rotondi Mario , Magri Flavia
Published: January 2025

Context

Thyroid nodules classified cytologically as low-risk indeterminate lesions (TIR3A) on fine-needle aspiration biopsy (FNAB) present a clinical challenge due to their uncertain malignancy risk.

Objective

This single-center study aimed to evaluate the natural history of TIR3A nodules.

Methods

FNABs performed between July 2017 and December 2019 were retrospectively retrieved and patients, with TIR3A nodules were evaluated at baseline and throughout a follow-up based on ultrasound (US) parameters and clinical data.

Results

The final study group encompassed 371 patients with an initial TIR3A cytological result. Among them, 102 were directed to surgery after the first endocrinological evaluation, and 269 were directed to conservative follow-up. Repeat FNAB was performed in 120 out of 269 and 13 further patients underwent surgery following FNAB repetition. The malignancy rate among TIR3A nodules was 16.5%, with most interventions being performed for reasons unrelated to the TIR3A result. Repeat FNAB provided a more definitive diagnosis in 40% of cases, with a 5% increase in malignancy risk. The remaining patients were monitored with clinical and US follow-up. Among all patients with TIR3A cytology managed conservatively (149 without FNAB repetition and 66 with at least one FNAB repetition), no significant changes in nodule size and/or US pattern were observed during a median follow-up of 3.3 years.

Conclusion

These findings suggest that active surveillance is a safe option for managing TIR3A nodules, particularly when no additional risk factors are present. The study highlights the role of repeat FNAB in reducing unnecessary surgeries and underscores the generally indolent nature of TIR3A nodules.
Adrenal Insufficiency Due to Adrenal Insult Following Acute Pancreatitis in a Child
Authors: Sasidharan Pillai Sabitha , Robilliard Renee , Fredette Meghan E , Topor Lisa Swartz , Della Grotta Lynn , Serrano-Gonzalez Monica
Published: January 2025

We report an 8-year-old girl who developed primary adrenal insufficiency (AI) in the setting of severe acute pancreatitis. Symmetrically thickened centrally hypoenhancing adrenal glands were incidentally noted on computed tomography (CT) of the abdomen obtained for evaluation for pancreatitis. Laboratory studies included a low morning cortisol level (1.5 µg/dL [41.4 nmol/L], reference range, 5.5-20 µg/dL [151.7-551.7 nmol/L]) on day of hospitalization (DOH) 5. Cortisol did not rise following administration of 250 µg of cosyntropin. She had elevated adrenocorticotropin (ACTH), low aldosterone and dehydroepiandrosterone sulfate levels, normal very long-chain fatty acid levels, and negative 21-hydroxylase autoantibody. Follow-up CT of the abdomen on DOH 9 demonstrated bilateral adrenal gland enlargement with central hypoenhancement and slightly shaggy appearance at the margins. A diagnosis of AI due to adrenal gland injury in the setting of acute pancreatitis was made. The adrenal injury was attributed to ischemic injury, as there were no findings to suggest substantial hemorrhage. Hydrocortisone and fludrocortisone therapies were initiated. Magnetic resonance imaging of the abdomen obtained 8 months later showed diminutive adrenal glands with a marked decrease in size compared to the initial CT scan finding. She has continued to require replacement doses of hydrocortisone and fludrocortisone.
Preoperative Diffusion Tensor Imaging and Neurite Dispersion and Density Imaging in Isocitrate Dehydrogenase-Mutant Grade 2 and 3 Gliomas: Definition of Tumor-Related Epilepsy and Predictive Factors of Seizure Outcomes Based on a Single-Center Retrospective Case Series
Authors: Bono Beatrice C. , Grimi Alessandro , Di Toro Artem Emanuele , Ninatti Gaia , Franzini Andrea , Rossini Zefferino , Tropeano Maria Pia , Navarria Pierina , Bellu Luisa , Simonelli Matteo , Dipasquale Angelo , Savini Giovanni , Levi Riccardo , Politi Letterio S. , Pessina Federico , Riva Marco
Published: January 2025

BACKGROUND AND OBJECTIVES:

Understanding and managing seizure activity is crucial in neuro-oncology, especially for highly epileptogenic lesions like isocitrate dehydrogenase (IDH)-mutant gliomas. Advanced MRI techniques such as diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) have been used to describe microstructural changes associated with epilepsy. However, their role in tumor-related epilepsy (TRE) remains unclear. This study aims to investigate the role of DTI and NODDI tumor-derived metrics in defining TRE and predicting postoperative seizure outcomes in patients undergoing surgical resection for IDH-mutant grade 2 and 3 gliomas.

METHODS:

This was a single-center retrospective study. Preoperative DTI parameters included fractional anisotropy and mean diffusivity. NODDI parameters included neurite density index (NDI), orientation dispersion index, and free-water fraction (FWF). These metrics were calculated within three volumes of interest (fluid-attenuated inversion recovery [FLAIR] tumor volume, FLAIR peripheral zone, and FLAIR central zone [Fcz]) and correlated with seizure presentation, type, and postoperative control, which was reported according to the Engel classification system.

RESULTS:

Fifty-seven patients were included in this study. Increased NODDI-derived FWF-Fcz (P = .031) and NDI-Fcz (P = .046) values correlated with preoperative generalized seizure presentation, although only the FWF-Fcz confirmed its statistical significance (P = .047) in the multivariate analysis. Lower mean diffusivity-FLAIR tumor volume correlated with poor postoperative seizure control both in the univariate (P = .015, P = .026) and multivariate analyses (P = .024, P = .036), while a trend toward significance was found between higher NDI-FLAIR peripheral zone and worse seizure control (P = .055).

CONCLUSION:

DTI and NODDI tumor-derived quantitative parameters may define TRE and predict postoperative seizure outcomes in patients with IDH-mutant gliomas. Notably, DTI metrics were found to be independent predictors of postoperative seizure outcomes, while preoperative NODDI parameters correlated with seizure presentation. Further research is warranted to validate our findings and to better understand the underlying mechanisms driving TRE.
Dietary fat quantity and composition influence hepatic lipid metabolism and metabolic disease risk in humans
Authors: Srnic Nikola , Westcott Felix , Caney Eleanor , Hodson Leanne
Published: January 2025

The excessive accumulation of intrahepatic triglyceride (IHTG) in the liver is a risk factor for metabolic diseases, including type 2 diabetes and cardiovascular disease. IHTG can excessively accumulate owing to imbalances in the delivery, synthesis, storage and disposal of fat to, in and from the liver. Although obesity is strongly associated with IHTG accumulation, emerging evidence suggests that the composition of dietary fat, in addition to its quantity, plays a role in mediating IHTG accumulation. Evidence from human cross-sectional and interventional studies indicates that diets enriched with saturated fat compared to other fat types and carbohydrates produce divergent effects on IHTG content. However, the mechanistic reasons for these observations remain unknown. Given the challenges of investigating such mechanisms in humans, cellular models are needed that can recapitulate human hepatocyte fatty acid metabolism. Here, we review what is known from human studies about how dietary fat, its quantity and composition contribute to IHTG accumulation. We also explore the effects of fatty acid composition on hepatocellular fat metabolism from data generated in cellular models to help explain the divergences observed in in vivo studies.
Global Giants and Local Stars: How Changes in Brand Ownership Affect Competition
Authors: Alviarez Vanessa , Head Keith , Mayer Thierry
Published: January 2025

Large beer and spirits makers expanded abroad mainly by acquiring local brands. Exploiting market share data in 76 countries and changes in brand ownership from 2007 to 2018, we estimate that owners matter little for brand performance, except via a negative consumer response to foreign ownership. Counterfactuals indicate that market power increases were large enough to yield higher profits for most mergers without relying on fixed-cost savings. Emulating procompetition policies used by the United States and European Union could have saved South American consumers up to 18 percent. US beer prices would be 3–4 percent higher without DOJ-enforced divestitures. (JEL F23, G34, K21, L13, L25, L66)
A Random Dictator Is All You Need
Authors: Arieli Itai , Babichenko Yakov , Talgam-Cohen Inbal , Zabarnyi Konstantin
Published: January 2025

We study information aggregation with a decision-maker aggregating binary recommendations from symmetric agents. Each agent’s recommendation depends on her private information about a hidden state. While the decision-maker knows the prior distribution over states and the marginal distribution of each agent’s recommendation, the recommendations are adversarially correlated. The decision-maker’s goal is choosing a robustly optimal aggregation rule. We prove that for a large number of agents for the three standard robustness paradigms (maximin, regret, and approximation ratio), the unique optimal aggregation rule is “random dictator.” We further characterize the minimal regret for any number of agents through concavification. (JEL D81, D82, D83)
Ο ρόλος των αδιποκινών SFRP5 (Secreted Frizzled Related Protein) και WNT5A (Wingless-Related Integration Site 5A) στην παχυσαρκία κατά την παιδική και εφηβική ηλικία
Authors: Κουτάκη Διαμάντω
Published: January 2025

ΕΙΣΑΓΩΓΗ: Ένα νέο δίδυμο αδιποκινών, η αντιφλεγμονώδης Sfrp5 (secreted frizzled-related protein 5) και η προφλεγμονώδης Wnt5a (Wingless-related integration site 5A) φαίνεται να διαδραματίζουν βασικό ρόλο στην παθογένεση της παχυσαρκίας και τις μεταβολικές της επιπλοκές. Παρόλο που έχουν διεξαχθεί αρκετές μελέτες σε ενήλικες, υπάρχουν περιορισμένα δεδομένα σε παιδιά και εφήβους, ειδικά σε σχέση με την υπερβαρότητα και την παχυσαρκία. ΣΚΟΠΟΣ: Η διερεύνηση της επίδρασης ενός δομημένου, εξατομικευμένου προγράμματος παρέμβασης στον τρόπο ζωής, διατροφής, ύπνου και σωματικής άσκησης στη συγκέντρωση των Wnt5a και Sfrp5 σε παιδιά και εφήβους με παχυσαρκία, υπερβαρότητα και φυσιολογικό δείκτη μάζας σώματος (ΔΜΣ). ΑΣΘΕΝΕΙΣ ΚΑΙ ΜΕΘΟΔΟΙ: Στην παρούσα μελέτη, διερευνήσαμε τις συγκεντρώσεις των Sfrp5 και Wnt5a, το ολικό οξειδωτικό (TOS) και αντιοξειδωτικό (TAS) status, την υψηλής ευαισθησίας C-αντιδρώσα πρωτεΐνη (hs-CRP), και τις κυτοκίνες IL-1α, IL-1β, IL-2, IL-6, IL-8, IL-12 και TNF-α σε 120 παιδιά και εφήβους (μέση ηλικία± SE: 11,48±0,25 έτη, 48 προεφηβικά και 72 εφηβικά, 74 αγόρια και 46 κορίτσια) πριν και 1 χρόνο μετά την εφαρμογή ενός δομημένου, εξατομικευμένου προγράμματος παρέμβασης στον τρόπο ζωής, διατροφής, ύπνου και σωματικής άσκησης. ΑΠΟΤΕΛΕΣΜΑΤΑ: Με βάση τα κριτήρια της International Obesity Task Force, οι συμμετέχοντες ταξινομήθηκαν στις εξής ομάδες: νοσογόνος παχυσαρκία (n=63, 52,5%), παχυσαρκία (n=21, 17,5%), υπερβαρότητα (n=22, 18,33%) ή φυσιολογικός ΔΜΣ (n=14,11,67%). Μετά το πρόγραμμα παρέμβασης στον τρόπο ζωής για 1 έτος, υπήρξε σημαντική βελτίωση στις ανθρωπομετρικές παραμέτρους (ΔΜΣ, ΔΜΣ-z score, διαστολική αρτηριακή πίεση, περίμετρο μέσης/περίμετρο ισχίων), στις παραμέτρους σύστασης του σώματος, στα ηπατικά ένζυμα, στο προφίλ λιπιδίων, στους δείκτες φλεγμονής και στο προφίλ ευαισθησίας στην ινσουλίνη (HbA1C, δείκτης HOMA) σε όλους τους ασθενείς. Η αδιποκίνη Sfrp5 μειώθηκε σε άτομα με παχυσαρκία (p<0,01), ωστόσο, αυξήθηκε σημαντικά (p<0,05) σε ασθενείς με νοσογόνο παχυσαρκία. Η ανάλυση γραμμικής παλινδρόμησης έδειξε ότι ο TNF-α και η συστολική αρτηριακή πίεση ήταν οι καλύτεροι θετικοί προγνωστικοί δείκτες και η hs-CRP ήταν ο καλύτερος αρνητικός προγνωστικός δείκτης για την αρχική συγκέντρωση του Sfpr5, η συγκέντρωση γλυκόζης για τη μεταβολή του Sfrp5 (ΔSfrp5), ενώ οι TNF-α και TAS ήταν οι καλύτεροι θετικοί προγνωστικοί δείκτες για την συγκέντρωση του Sfpr5 κατά την ετήσια αξιολόγηση. Οι συγκεντρώσεις του Wnt5a ήταν κάτω από το όριο ανίχνευσης (0.057ng/mL) στο 96% του πληθυσμού της μελέτης και αποκλείστηκαν από περαιτέρω αναλύσεις. ΣΥΜΠΕΡΑΣΜΑΤΑ: Αυτά τα ευρήματα υποδηλώνουν ότι ο Sfrp5 σχετίζεται με την νοσογόνο παχυσαρκία και αυξάνεται μετά την απώλεια βάρους σε παιδιά και εφήβους με νοσογόνο παχυσαρκία. Σχετίζεται επίσης με τη μεταβολική ομοιόσταση, καθώς και με τη φλεγμονή και την οξειδωτική κατάσταση.
Θέση, αντίληψη και χρήση της αξιολόγησης στο πλαίσιο των αναπτυξιακών παρεμβάσεων στην Ελλάδα
Authors: EEA Ελληνική Εταιρεία Αξιολόγησης
Published: January 2025

Η κ.Μιράντα Θεοδωροπούλου είναι αριστούχος κάτοχος πτυχίου Κοινωνιολογίας από το Πάντειο Πανεπιστήμιο (1993) και μεταπτυχιακού τίτλου "Ευρωπαϊκή Οργάνωση και Διπλωματία" από το Πανεπιστήμιο Αθηνών, Τμήμα Πολιτικής Επιστήμης και Δημόσιας Διοίκησης (1996) . Από το 1996 έως το 2000 εργάστηκε στην εταιρεία Συμβούλων ΤΕΚΜΩΡ και για μικρό διάστημα στο Ελληνικό Συμβούλιο για τους Πρόσφυγες, ενώ από το 2002 έως σήμερα είναι στέλεχος της ΜΟΔ ΑΕ και υπηρετεί στη Μονάδα Αξιολόγησης της Ειδικής Υπηρεσίας Συντονισμού και Παρακολούθησης Δράσεων Ευρωπαϊκού Κοινωνικού Ταμείου (ΕΥΣΕΚΤ) – η οποία ανήκει στην Εθνική Αρχή Συντονισμού του ΕΣΠΑ - . Ασχολείται με το συντονισμό μελετών αξιολόγησης ΕΚΤ (σύνταξη προδιαγραφών και παρακολούθηση μελετών, σύνταξη τεχνικών οδηγιών και υποστήριξη Διαχειριστικών Αρχών σε θέματα αξιολόγησης και δεικτών ΕΚΤ). Κατά την τρέχουσα προγραμματική περίοδο 2014-2020 ασχολείται με τα θέματα συντονισμού του σχεδιασμού και της παρακολούθησης/μέτρησης των δεικτών ΕΚΤ σε όλα τα Επιχειρησιακά Προγράμματα του ΕΣΠΑ.
Caregivers’ self-medication practices for perceived febrile illnesses among under-five children in central river region, the Gambia
Authors: Ndimballan Haita , Adebowale Ayo , Ajayi Ikeoluwapo
Published: January 2025

Background Drug use for under-five children by their caregivers without professional advice constitutes a public health challenge due to its potential for drug-drug interactions, overdose, and antimicrobial resistance. In the Gambia, there are only a handful of programs that control self-medication despite its harmful effects on children. Self-medication of under-five children has been rarely reported in rural areas of the Gambia. Therefore, we assessed the knowledge, practices, and reasons for the self-medication of under-five children for perceived febrile illnesses by their caregivers in the Central River Region, the Gambia. Methods This cross-sectional study was conducted between September and October 2023 among caregivers (n=406) of under-five children from the Central River Region, The Gambia. A mixed-method approach was used to collect data. Knowledge of childhood febrile illnesses was assessed using 9-item questions. Focus group discussions and In-depth interviews were conducted using question guides. Data were analyzed using descriptive statistics, Chi-square test, and binary logistic regression (α=5%). Qualitative data were analyzed using Atlas Ti. Results The caregivers' mean age (SD) was 31.1±9.6 years and most 330(81.3%) were females. The prevalence of self-medication was 21.43% and 165(40.6%) of the caregivers had good knowledge of childhood febrile illnesses. Respondents who received information from friends (aOR=2.564; p=0.002) and those who got advice from neighbours (aOR=7.008; p=0.011) on childhood febrile illnesses were likelier to self-medicate than those who did not. Long waiting hours, lack of drugs at health facilities, and experience in self-medication were the reasons promoting self-medication in under-five children. Conclusions The prevalence of self-medication among caregivers of under-five children is low, and more than half of them had poor knowledge of childhood febrile illnesses. The practice of self-medication for under-five children was more common among younger caregivers. Caregivers of under-five children should be sensitized on the health implications of self-medication in The Gambia.
The genome sequence of the plant pathogen, Mucor piriformis A. Fisch.
Authors: Buddie Alan , Kermode Anthony , Gaya Ester ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: January 2025

We present a genome assembly from a specimen of Mucor piriformis (Mucoromycota; Mucoromycetes; Mucorales; Mucoraceae). The genome sequence spans 34.90 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 43.89 kilobases in length.
SOCIAL PROTECTION IN THE CONTEXT OF CLIMATE CHANGE
Authors: Eyvazova Tutu R.
Published: January 2025

The article is devoted to the analysis of current social protection measures applied in the context of climate change. The subject of the analysis is the forms of implementation of social protection.
Purpose. The author sets the task of identifying the optimal ways of implementing social protection measures as an important area of social security.
Methodology. The study is based on a systems approach, structural-functional and comparative-historical analysis, as well as general scientific and special scientific methods.
Results. In accordance with climate change, it is proposed to make appropriate changes to social policy in the field of health care and promotion of healthy lifestyles. Disease prevention is based primarily on compliance with the basic provisions of social security, including those related to the ecological environment.
Practical significance. The results of the study can be used in the sphere of socio-political planning and forecasting.
The concept of ambiguous loss: couples therapy in the context of life-threatening illness
Authors: Janusz Bernadetta , Dejko-Wańczyk Karolina
Published: January 2025

Celem niniejszej pracy jest omówienie zjawiska antycypowanej utraty oraz przedstawienie propozycji pracy terapeutycznej z parą w kontekście przewlekłej lub zagrażającej życiu choroby jednego z partnerów. W pierwszej części artykułu wprowadzamy antropologiczną koncepcję stanów liminalnych, to jest sytuacji przejściowych związanych ze zmianą życiowego statusu. Jest ona punktem wyjścia do omówienia psychologicznej sytuacji pary, która pojawia się w reakcji na diagnozę choroby u jednego z partnerów. Następnie prezentujemy koncepcję niejednoznacznej utraty (ang. ambiguous loss) autorstwa Pauline Boss, amerykańskiej badaczki i terapeutki rodzinnej. Koncentrujemy się na przedstawieniu zjawiska w relacyjnej i emocjonalnej przestrzeni pary intymnej. W drugiej części pracy opisujemy zjawisko antycypowanej utraty (ang. anticipated loss). Jest to szczególny typ niejednoznacznej utraty, który uwydatnia złożone procesy emocjonalne i relacyjne pojawiające się w okresie poprzedzającym spodziewaną śmierć partnera lub partnerki. Prezentację materiału teoretycznego uzupełniamy fragmentem sesji terapii pary obrazującym specyfikę pracy terapeutycznej w kontekście antycypowanej utraty. Podsumowanie pracy zawiera wskazówki dotyczące terapeutycznej pracy z parą w opisanej sytuacji.
Surgical management and multidisciplinary care of Dieulafoy’s lesion in Klippel-Trenaunay-Weber Syndrome
Authors: Karim Sulaiman , Pert Lauren , Khan Afnan , Santos Ariel
Published: January 2025

A man in his early 40’s with Klippel-Trenaunay-Weber syndrome (KTWS) was referred to the surgical team for treatment of massive upper gastrointestinal bleeding. This syndrome is a rare congenital condition that leads to abnormal development of blood vessels, bones, and soft tissues. Although venous malformations are common in KTWS, gastrointestinal involvement is rare but can cause life-threatening bleeding. In this case, a series of diagnostic tests, including endoscopic and angiographic examinations, failed to identify the etiology of the bleeding. Surgical intervention was required after conservative and interventional radiologic therapies proved unsuccessful. A Dieulafoy’s lesion was identified in the proximal stomach and later confirmed histologically. The patient required a multidisciplinary care involving gastroenterology, interventional radiology, and general surgery for successful management.
The pathogenesis of Dieulafoy’s lesion is not well understood, and interventions vary from endoscopic to surgical management. The treatment of Dieulafoy’s lesion is not well- described in patients with KTWS, especially in cases in which endoscopic treatments have failed.
Keywords: Klippel-Trenaunay Syndrome; Dieulafoy’s lesion; gastrointestinal bleeding; radiology, interventional; endoscopy; surgical treatment
Congenital methemoglobinemia in old age
Authors: Sherani Muhammad Talha , Ali Karamat , Rehman Lailamah
Published: January 2025

Chest infections and ischemic heart disease are the most common causes of shortness of breath and cyanosis in old age. However, the hemoglobinopathies should be considered if the cardiac cause is ruled out, cyanosis that is not responding to oxygen therapy and antibiotic treatment. A 75-year-old retired soldier was admitted to the inpatient department of a tertiary care hospital with symptoms of cyanosis, shortness of breath and fever. Cyanosis was acrocyanosis in nature and not relieved on oxygen therapy.
An initial diagnosis of Lower respiratory tract infection was initiated. However, the cyanosis showed no signs of improvement. Alternate diagnosis was considered, and the patient was started on treatment of ischemic heart disease that included nitrates which further led to worsening of his condition. Blood methemoglobin levels were raised which established the diagnosis of methemoglobinemia. The fast-moving dark brown color band of Hb M on gel electrophoresis confirmed the diagnosis of Hb M. The patient was started on IV ascorbic acid with the patient showing clinical improvement within 36 hours.
The patients presenting with unexplained acrocyanosis should not be treated with oxidizing agents like nitrates, irrespective of age and management of another disease, unless the cause of cyanosis has been established.
A late diagnosis and treatment of coarctation of aorta six months after presenting with aortic dissection
Authors: Sheedy Maxwell , Cihan Chevik  , Magdiel Trinidad-Hernandez
Published: January 2025

Coarctation of the aorta (CoA) is a congenital condition causing narrowing of the aorta, typically just after the left subclavian artery. Most patients with CoA are diagnosed at birth or during infancy. However, they can also be undiagnosed later in adulthood with minimal symptoms to show or treatment-resistant hypertension.  However, some patients may also present with life-threatening medical emergencies that may lead to an undiagnosed CoA. This case is a 40-year-old man with hypertension who presented with a late diagnosis of CoA on computed tomography imaging six months after ascending aorta dissection repair. The patient's CoA was repaired via an endovascular approach with stent placement and post-dilatory balloon angioplasty. His CoA segmental blood pressure gradient was 25 mmHg and decreased to 3 mmHg post-procedure. The patient has done well post-procedure, and his blood pressure had been within normal limits.
Key words: Aortic coarctation, aortic dissection, hypertension, congenital heart defect
Comparative Population Studies at Fifty: Views on the Past, Present, and Future
Authors: Trappe Heike , Rau Roland , Schiefer Katrin , Spieß C. Katharina
Published: January 2025

The 50th volume of Comparative Population Studies (CPoS) is a significant milestone in the journal’s history, offering us the opportunity to reflect on its development into a key platform for population research, major achievements, and future aspirations. Besides a retrospective, we present a forward-looking perspective, outlining our vision for the journal’s trajectory in an ever-changing scientific landscape. Furthermore, we offer insights from 50 years of CPoS, including the total number of submissions, the geographic origins of our authors, and an analysis of the journal’s most downloaded articles. This editorial is the first in a series accompanying CPoS volume 50 in our anniversary year. Further editorials by former CPoS editors, publishers, and authors will follow, giving an overview of the editorial processes, guiding principles, and strategic considerations that have and will continue to shape the journal’s identity and impact.
* This article belongs to a series celebrating the journal's 50th anniversary.
Chiari malformation as a differential diagnosis of recurrent syncope
Authors: Figueiredo Filipa , Valido Teresa , Bastos Martim , Chumbo Carolina , Oliveira Jéssica , Paulo Joana Batista , Rocha Marta
Published: January 2025

Arnold-Chiari malformations are rare anomalies involving inferior displacement of the cerebellar tonsils and hindbrain through the foramen magnum. We present the case of a 19-year-old woman with a relatively rare presentation of recurrent syncope. The patient underwent surgical treatment with resolution of the symptoms. Few cases of surgical treatment have been described. This case underscores the importance of considering Chiari malformations in the differential diagnose of a common symptom - recurrent syncope - and the relevance of considering these patients for surgical treatment.
Recurrent cardiac tamponade as a complication of prolonged left bundle branch area pacing
Authors: Kamarulzaman Nurshafira , Wan Abdullah Wan Nur Amirah , Othman Mohd Khairi , W Isa W Yus Haniff , Yusof Zurkurnai , Mohamad Jamali Ahmad Aizuddin , Muhammad Zulkeflee
Published: January 2025

Post-cardiac injury syndrome (PCIS) is one of the complications of cardiac interventional procedures. This condition has been postulated to be due to an immune reaction, especially with pacemaker lead implantation. Patients with PCIS can have uncomplicated pericardial effusion until they develop cardiac tamponade. The management of PCIS, which can be conservative management or require pericardiocentesis or surgery depends on the patient’s clinical symptoms. As the left bundle branch area pacing (LBBAP) implantation technique and technology are still new, it is associated with longer procedural time than conventional pacemaker implantation. Herein, we report a case of PCIS in a patient who had a prolonged LBBAP procedure due to difficult anatomy and presented with recurrent cardiac tamponade.
Unmasking of normocalcemic primary hyperparathyroidism after sodium-glucose cotransporter-2 inhibitor initiation
Authors: Dolapsakis Christodoulos , Karofylakis Emmanouil , Chalvatzis Stamatios
Published: January 2025

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have complex interactions with bone metabolism, including an increase in parathyroid hormone (PTH) levels. Here we report a case of a SGLT2 inhibitor-induced hypercalcemia due to primary hyperparathyroidism. In the subset of patients with normocalcemic primary hyperparathyroidism, SGLT2 inhibitor initiation can unmask the disorder causing overt hypercalcaemic hyperparathyroidism. Although normocalcemic primary hyperparathyroidism is a rare entity, we propose obtaining a baseline PTH level before starting a SGLT2 inhibitor in patients with calcium levels in the upper limit of normal and normal total 25-hydroxyvitamin D levels, especially if they are under vitamin D supplementation. PTH should be rechecked in order to exclude overt primary hyperparathyroidism.
AS ARTIMANHAS DA RESISTÊNCIA TORCEDORA: FUTEBOL, LINGUAGEM E PODER
Authors: Lopes Felipe Tavares Paes
Published: January 2025

Este artigo objetiva analisar as estratégias de resistência adotadas por torcedores de futebol face às transformações que esse esporte vem sofrendo nos últimos anos, bem como as maneiras através das quais essas formas de resistência contribuem para problematizar as metáforas do futebol como ópio do povo e como teatro. Para tanto, baseia-se nas informações obtidas em entrevistas com lideranças de torcidas organizadas e coletivos de torcedores e observações feitas em partidas de futebol, protestos de torcedores, reuniões de coletivos e visitas a estádios. Entre outras coisas, mostra que as referidas metáforas não conseguem lidar satisfatoriamente com o conflito e a contestação existentes hoje em dia no futebol, reforçando o “mito do receptor passivo”.
Salas de estar como territórios sonoros: considerando outras territorialidades da música ao vivo
Authors: Pires Victor de Almeida Nobre
Published: January 2025

O presente artigo tem como objetivo pensar a importância da territorialidade para a produção da música ao vivo contemporânea. A partir da análise da turnê “Na Sala de Estar” da banda gaúcha Apanhador Só, da rede global Sofar Sounds e de iniciativas independentes como a Undertow Music Collective, busca-se entender, com base nas noções de território-rede, territorialidade e território sônico-musical, a apropriação de ambientes domésticos para a produção de concertos independentes. Contribuindo para uma percepção das estratégias de ocupação de novos produtores, artistas e fãs ao redor do mundo.
Das Cenas e Circuitos às Territorialidades (Sônico-Musicais).
Authors: Herschmann Micael
Published: January 2025

Tomando como referência não só a literatura especializada, mas também pesquisas realizadas, o objetivo deste trabalho é subsidiar o debate teórico-metodológico que envolve os conceitos de cena, circuito e territorialidades, os quais são empregados largamente pelos especialistas que atuam na interface da comunicação e da música no Brasil.
Assessment and management of leg oedema in primary care
Authors: Nazarko Linda
Published: January 2025

Leg oedema is a common symptom that can be misunderstood and misdiagnosed. It affects an estimated 400,000 people in the UK ( Lymphoedema support network, 2021 ) and around 240,000 of those people have lymphoedema ( House of Commons, 2013 )

Misdiagnoses can lead to unnecessary investigations and treatment that is at best ineffective and worst harmful. This article aims to provide the nurse with information on how to assess, diagnose and manage leg oedema in primary care.

Here, Linda Nazarko explains how it can be assessed and managed in a general practice setting
Chronic obstructive pulmonary disease: all things inhaled
Authors: Scullion Jane
Published: January 2025

Jane Scullion looks at the latest evidence linked to prescribing for COPD patients
Dominó astronômico: uma estratégia para a aprendizagem sig-nificativa no ensino fundamental
Authors: De Carvalho Espedito Fabricio , Da Silva Freitas Dagoberto
Published: January 2025

A Astronomia desperta o interesse e o fascínio dos seres humanos desde as primeiras observações realizadas há milhares de anos. Promover o ensino e aprendizagem dessa primordial ciência através de recursos que favoreçam conhecimentos contextualizados e significativos configura-se como o objetivo desse trabalho. A construção do Dominó Astronômico foi fundamentada na Gamificação, uma metodologia ativa que se vale da mecânica, da motivação, do engajamento, das regras e feedbacks dos jogos integrando e interagindo com os conhecimentos em Astronomia culminando em um processo de ensino e aprendizagem dinâmico e significativo para os estudantes. A atividade gamificada Dominó Astronômico se constitui como produto educacional construído no Mestrado Profissional em Ensino de Astronomia da Universidade Estadual de Feira de Santana. O desenvolvimento ocorreu nos Anos Finais e na EJA do Ensino Fundamental das redes públicas municipais de Dias d’Ávila e Mata de São João, no estado da Bahia. O produto tem auxiliado docentes e estudantes associando informações prévias, que servem como base para a construção de novos conhecimentos cientificamente embasados. Proporcionando a compreensão de diversificados temas que conectam Astronomia de forma interdisciplinar com tecnologia, desenvolvimento da humanidade e descobertas cientificas relevante, que resultam no ensino e aprendizagem lúdica e significativa.
10 Anos do MPAstro: passado, presente e futuro
Authors: Da Rocha Poppe Paulo César , Fernandes Martin Vera Aparecida , Geraldête Pereira Marildo
Published: January 2025

O Mestrado Profissional em Astronomia (MPAstro), aprovado em 2013 pela Área de Ensino da CAPES, completa no corrente ano uma década de formação pós-graduada gratuita, qualificada e interdisciplinar, parte da contribuição social direcionada aos professores(as) das redes básica e superior de ensino. A presente contribuição objetiva remontar a história da jornada profícua do MPAstro, na qual começa a partir do ano 2000 com o financiamento dos primeiros projetos integrados de ensino, pesquisa e extensão universitária. Nesses, as primeiras ações foram semeadas e plantadas, permitindo culminar, posteriormente, na implantação e consolidação do atual Programa de Pós-Graduação que obteve na última avaliação quadrienal da CAPES a Nota 4. As perspectivas sempre são desafiadoras, sobretudo no cenário de contingenciamento e descrédito na ciência. No entanto, a marca que será atingida em breve com a formação de uma centena de mestres, renova as esperanças e motiva a caminhada rumo ao doutorado profissional.
A formação continuada de professores nos institutos federais de edu-cação: uma análise documental
Authors: Cantuária Borges Roberta , Couto Pimentel Susana
Published: January 2025

Este estudo é a gênese de uma pesquisa em andamento sobre o processo de inclusão de alunos com deficiência na Educação Profissi-onal Tecnológica e a importância da formação continuada de professores com vistas ao fortalecimento da permanência estudantil. O recorte feito para este trabalho busca analisar como a formação continuada de professores, acerca da inclusão de estudantes com deficiência, tem sido abordada nos aportes legais e na literatura acerca do Instituto Federal de Educação, Ciência e Tecnologia da Bahia (IFBA). Trata-se de uma pesquisa de natureza qualitativa pautada na análise de documentos institucionais. Os resultados apontam que o IFBA tem avançado nas discussões e na consolidação de políticas de formação docentes numa perspectiva inclusiva voltadas para promover a permanência, participação e aprendizagem dos estudantes com deficiência nessa instituição.
Evaluating Sex Differences in Language Abilities Within Down Syndrome and Autism Spectrum Disorder
Authors: Udhnani Manisha D. , Lee Nancy Raitano
Published: January 2025

Down syndrome (DS) and autism spectrum disorder (ASD) are two neurodevelopmental disorders characterized by impairments in language. Most studies do not consider the possible role sex differences may play in language profiles. Thus, the current study aimed to evaluate whether parent-reported structural and pragmatic language vary as a function of sex in youth with DS (n = 37), ASD (n = 106), and typical development (TD; n = 61). Findings suggest a female advantage in both structural and pragmatic language in DS; in contrast, no sex differences were found for either ASD or TD. Results suggest that males with DS may require more extensive interventions for language. Future research should investigate how age, IQ, and mode of measurement may impact the nature of these observations.
From "Oppressors" to "Oppressed": Baltic Russian Post-Soviet Speakers in Search of a New Identity through Social Networking
Authors: Fedorova Kapitolina , Tshuikina Natalia
Published: January 2025

Abstract: Following the dissolution of the Soviet Union, newly independent states were confronted with the repercussions of the Soviet language policy; simultaneously, Russian speakers in almost all post-Soviet countries experienced a radical shift in their status: Russian was transformed from a state language to a language without an official status, and its speakers found themselves as a minority group. The paper explores the challenges encountered by Russian speakers in the Baltic states of Estonia, Latvia, and Lithuania. It examines the strategies employed by these individuals to construct new identities within the altered sociocultural landscape, with a specific emphasis on the role of social networking and online communication. Digitalization strengthens local Russophone communities by facilitating identity-building and enhancing connectivity within these groups, which can be revealed through the analysis of the patterns of language use and the primary ideological concepts and constructs involved in shaping the group and individual identities of Russian speakers in the Baltic states.
Decolonization Discourse and the Pluricentric Language Situation in Kazakhstan
Authors: Abdrakhmanov Dauren , Shaibakova Damina
Published: January 2025

Abstract: The term "decolonization"' has become more prevalent in Kazakhstani public discourse, in stark contrast to Russia. The research seeks to examine the evolution and distinctive features of decolonization discourse in Kazakhstan and Russia. The research material was gathered from contemporary media sources. The study employed critical discourse analysis, a method that highlights the active nature of understanding, viewing language use as reflective of social practice, and emphasizing its reciprocal relationship with surrounding contexts, institutions, and social frameworks. The results indicate that historical content, the functions of the pluricentric Russian language, the transition to the Latin alphabet, and the renaming of toponyms and ergonyms as well as the change of anthroponyms are contentious points in the discourse of both Russia and Kazakhstan. Each discourse utilizes distinct formulations to describe the history of colonization and acts of decolonization, assigning different meanings to the same concepts. Russian develops unique linguistic varieties in Kazakhstan.
Single-polarization single-mode hollow-core anti-resonant fiber with nested stadium-shaped tubes
Authors: Xiao Yiming , Ren Shuai , Liu Houquan , Cheng Yu , Yuan Libo
Published: January 2025

A single-polarization hollow-core anti-resonant fiber (HC-ARF) with nested stadium-shaped tubes is proposed for single mode, low loss, and high birefringence characteristics. X-pol fundamental mode (FM) is coupled to the cladding mode (CM) by introducing four anti-resonant tubes and one resonant tube. Y-pol FM is tightly bound in the fiber core, thus achieving a high polarization extinction ratio (PER). In order to achieve a large bandwidth, a silicon layer was coated on the inner surface of the cladding tube, and by optimizing the structural parameters of the silicon-coated HC-ARF, HC-ARF for single-polarization single-mode transmission with high order mode extinction ratios (HOMERs) of 530 and PERs of 15,135 were obtained at 1.55 µm. In addition, single-polarization bandwidths up to 220 nm, birefringence levels higher than 10−5, and an ultra-low confinement loss (CL) of 5.0 × 10−2 dB/km have been achieved. The fiber has good bending characteristics, with a minimum bending loss of 0.52 dB/km at a bending radius of 4.0 cm in the y-direction and a minimum bending loss of 3.5 dB/km at a bending radius of 5.7 cm in the + x-direction. Structural deviation occurs during the actual manufacturing of fibers, and the structural deformation tolerance of fibers is evaluated for the purpose of the actual manufacturing of fibers.
Spectroscopy and efficient OPSL-pumped laser operation of Er:BaF2 crystal at 2.8 µm
Authors: Hou Wentao , Kalusniak Sascha , Püschel Stefan , Tanaka Hiroki , Xu Jun , Tang Jun , Kränkel Christian
Published: January 2025

We present growth, spectroscopy and efficient laser operation of the cubic fluoride crystal Er:BaF2 at 2.8 µm. An Er(3.6 at.%):BaF2 crystal was grown by the vertical Bridgman method. We reveal the thermal conductivities of pure BaF2 and Er:BaF2 crystals for different temperatures. The temperature-dependent cryogenic absorption spectra were investigated in the near-infrared range, and we determined the energetic positions of the Stark levels of the upper and lower laser multiplets 4I11/2 and 4I13/2, respectively. A strong absorption peak at 971.5 nm and a broad gain bandwidth around 2.7-2.9 µm with a large emission cross section at 2732 nm were found. Under pumping with an optically-pumped semiconductor laser (OPSL) at 971.5 nm, we obtained 0.4 W of output power at a wavelength of 2786 nm with a slope efficiency of 31%. The slope efficiency is the highest in reported for 3 µm lasers based on Er:BaF2 at present.
Wide-range control of surface plasmon dephasing time by the strong coupling between surface lattice and gap modes
Authors: Wang Lun , Ji Boyu , Xu Yang , Lang Peng , Zhao Zhenlong , Song Xiaowei , Lin Jingquan
Published: January 2025

In applications such as plasmonic sensors and plasmonic nanolasers, constructing metal nanostructures with a wide range of tunability of plasmonic dephasing times is becoming increasingly important. However, the manipulation range of the dephasing time is still limited from only a few femtoseconds to tens of femtoseconds. Here, we propose what we believe to be a novel method to greatly extend the tunable range of plasmonic dephasing time by leveraging the strong coupling between the plasmonic gap mode and the surface lattice resonance mode. The results demonstrate a tunable range of plasmonic dephasing times from about 23 fs to 166 fs, which is more than one order magnitude longer than those for traditional modulation methods. Moreover, the local near-field intensity of the strong coupling modes can increase up to about 2-fold of the intrinsic gap mode. This investigation opens up new opportunities for applications requiring control plasmon dephasing times over a large range and provides an effective approach for better understanding light-matter interactions.
Photonic generation of frequency-doubled microwave waveforms based on time-domain processing
Authors: Lan Xiaohong , Jiang Yang , Xu Jing , Zi Yuejiao , Bai Guangfu , Tian Jing , Linghu Shuangyi , Yu Jiancheng , Feng Jinjian , Long Qianyou , Luo Yunkun , Zhang Hui , Jiang Tingyi
Published: January 2025

A photonic approach for a frequency-doubled microwave waveforms generator based on time-domain processing is proposed and experimentally demonstrated. This approach achieves the generation of various frequency-doubled microwave waveforms by overlapping optical envelopes and performing mathematical operations on optical envelopes. Detailed theoretical analysis and simulations are provided. In the experiment, frequency-doubled bright and dark parabolic waveforms, frequency-doubled sawtooth and reversed-sawtooth waveforms, frequency-doubled triangular waveform, and frequency-doubled square waveform are successfully generated, which agree well with the theoretical expectations. This method achieves frequency-doubled waveforms generation in an intuitionistic and a convenient way from the perspective of time-domain processing, which effectively eliminates the need for strict manipulation of modulation sidebands and may offer a new access to developing frequency-doubled microwave waveforms generators.