bluuebunny/crossref_metadata_2025 huggingface dataset:
Insight into Hurricane Maria Peak Daily Streamflows from the Development and Application of the Precipitation-Runoff Modeling System (PRMS): Including Río Grande de Arecibo, Puerto Rico, 1981–2017
Authors: Swain Eric D. , Bellino Jason C.
Published: November 2022

The Precipitation-Runoff Modeling System (PRMS) was used to develop a simulation of watershed hydrology on the island of Puerto Rico for the period 1981–2017, concentrating on the Río Grande de Arecibo, a river with some of the highest streamflows on the island. This development is part of the U.S. Geological Survey’s (USGS) National Hydrologic Model (NHM) infrastructure which supports coordinated, comprehensive, and consistent hydrologic modeling at the watershed scale for the coterminous United States (CONUS). A goal of the NHM program is to expand the domain outside of CONUS, leading to a PRMS application in Puerto Rico. This model was used to simulate the effects of Hurricane Maria on daily streamflow and provide information at locations where streamgages were damaged by the hurricane. Comparisons with streamflow estimates made by indirect methods in the field, up to ten times higher than simulated values, lends insight into the uncertainties in both the indirect methods and model simulated values and helps to identify potential error in the daily streamflow estimates. The PRMS can be applied to look at the effects of changes in climate and land use, water management, industrial and public water usage, and many other factors that affect hydrology on the island of Puerto Rico. The model is also designed as a support tool for the USGS National Water Census which provides comprehensive reporting of national information on withdrawal, conveyance, consumptive use, and return flow by water-use category.
Benefits of Participation in Clinical Trials: An Umbrella Review
Authors: Bouzalmate-Hajjaj Amira , Massó Guijarro Paloma , Khan Khalid Saeed , Bueno-Cavanillas Aurora , Cano-Ibáñez Naomi
Published: November 2022

Participation in randomised clinical trials (RCTs) entails taking part in the discovery of effects of health care interventions. The question of whether participants’ outcomes are different to those of non-participants remains controversial. This umbrella review was aimed at assessing whether there are health benefits of participation in RCTs, compared to non-participation. After prospective registration (PROSPERO CRD42021287812), we searched the Medline, Scopus, Web of Science and Cochrane Library databases from inception to June 2022 to identify relevant systematic reviews with or without meta-analyses. Data extraction and study quality assessment (AMSTAR-2) were performed by two independent reviewers. Of 914 records, six systematic reviews summarising 380 comparisons of RCT participants with non-participants met the inclusion criteria. In two reviews, the majority of comparisons were in favour of participation in RCTs. Of the total of comparisons, 69 (18.7%) were in favour of participation, reporting statistically significant better outcomes for patients treated within RCTs, 264 (71.7%) comparisons were not statistically significant, and 35 (9.5%) comparisons were in favour of non-participation. None of the reviews found a harmful effect of participation in RCTs. Our findings suggest that taking part in RCTs may be beneficial compared to non-participation.
Microalgae Diversity in Interim Wet Storage of Spent Nuclear Fuel in Serpong, Indonesia
Authors: Sugoro Irawan , Pikoli Megga Ratnasari , Rahayu Dyah Sulistyani , Puspito Marhaeni Joko , Shalsabilla Syalwa Ersadiwi , Ramadhan Firdaus , Fadila Diannisa Syahwa Rahma , Cici Ade , Tetriana Devita , Haribowo Dinda Rama , Rijal Mohammad Syamsul
Published: November 2022

The water quality in the interim wet storage of spent fuel (ISSF) needs to be monitored due to its function as a radiation shield. Water in ISSF pools must be free from microorganisms such as microalgae that live in a radioactive environment. Moreover, particular microalgae are capable of causing corrosion to stainless steel, which is a component of ISSF. Therefore, this study aims to determine the diversity of microalgae in the ISSF and those living in a radioactive environment, which cause corrosion. The microalgae were detected using the diversity and Palmer indices. The sampling of microalgae water was carried out by vertical filtration method at eight sites of ISSF. The results show that the diversity of microalgae (H′) was low due to radiation exposure in pool water, hence, only specific species can survive. The evenness (J′) of the microalgae was low, causing a high dominance index (C) value. Furthermore, the dominating species, namely, Chlorella sp. (Chlorophyceae), needs to be monitored because it has gamma radioresistance capabilities and can cause the corrosion of stainless steel.
Toxic Metals in Particulate Matter and Health Risks in an E-Waste Dismantling Park and Its Surrounding Areas: Analysis of Three PM Size Groups
Authors: Wu Yingjun , Li Guiying , An Taicheng
Published: November 2022

Heavy metals generated from e-waste have created serious health risks for residents in e-waste disposal areas. This study assessed how airborne toxic metals from an e-waste dismantling park (EP) influenced surrounding residential areas after e-waste control. PM2.5, PM10, and total suspended particles (TSP) were sampled from 20 sites, including an EP, residential areas, and an urban site; ten kinds of metals were analyzed using ICP-MS and classified as PM2.5, PM2.5–10, and PM10–100. Results showed that metals at the EP tended to be in coarser particles, while metals from residential areas tended to be in finer particles. A source analysis showed that metals from the EP and residential areas may have different sources. Workers’ cancer and non-cancer risks were higher when exposed to PM2.5–10 metals, while residents’ risks were higher when exposed to PM2.5 metals. As and Cr were the most strongly associated with cancer risks, while Mn was the most strongly associated with the non-cancer risk. Both workers and residents had cancer risks (>1.0 × 10−6), but risks were lower for residents. Therefore, e-waste control can positively affect public health in this area. This study provides a basis for further controlling heavy metal emissions into the atmosphere by e-waste dismantling and encouraging worldwide standardization of e-waste dismantling.
Social Determinants of Health and Child Maltreatment Prevention: The Family Success Network Pilot
Authors: Johnson-Motoyama Michelle , Moon Deborah , Rolock Nancy , Crampton David , Nichols C. Bailey , Haran Hanna , Zhang Yiran , Motoyama Yasuyuki , Gonzalez Eric , Sillaman Nicole
Published: November 2022

Child maltreatment is a highly prevalent public health concern that contributes to morbidity and mortality in childhood and short- and long-term health consequences that persist into adulthood. Past research suggests that social determinants of health such as socioeconomic status and intergenerational trauma are highly correlated with child maltreatment. With support from the U.S. Children’s Bureau, the Ohio Children’s Trust Fund is currently piloting the Family Success Network, a primary child maltreatment prevention strategy in Northeast Ohio that seeks to address these social determinants through pillars of service that include family coaching, financial assistance, financial education, parenting education, and basic life skills training. This study highlights the initial development phase of a pilot study. Plans for in-depth process and outcome evaluations are discussed. The project seeks to improve family functioning and reduce child protective services involvement and foster care entry in an economically disadvantaged region.
Specific Needs of Patients and Staff Reflected in the Design of an Orthopaedic and Rehabilitation Hospital—Design Recommendations Based on a Case Study (Poland)
Authors: Gawlak Agata , Stankiewicz Marta
Published: November 2022

This article presents results of the research conducted with the use of participatory methods by the Faculty of Architecture, Poznan University of Technology on architectural design of healthcare facilities. The studies concerned the needs of patients and hospital staff in an orthopaedic and rehabilitation hospital. Preferences and expectations of all the users of healthcare facilities should be considered as early as at the stage of planning and designing. The hospital profile and the type of its users predetermine the architectural design in the area of the building functions, its internal circulation and interior design. Participation of the user in the process of compiling design recommendations is a chance for a designer to confront the original assumptions with expectations and to adjust relevant solutions to factual needs of the users. This study, undertaken in a regional setting, provided an in-depth exploration of staff’s experiences of hospital space to indicate possible spatial improvements. Methods: The research was conducted on the basis of a case study of a renowned regional orthopaedic and rehabilitation hospital in Poznan, Poland. Rapid assessment methods and questions were examined to describe current approaches and synthesize results. Semi-structured interviews and thematic analysis identified staff and patient’s experiences. Result: Participation of hospital staff and patients resulted in design recommendations of high utility value. It was found that the two groups to a certain extent proposed similar recommendations; however, certain proposals submitted by the two groups were totally opposite. Conclusion: the research highlighted the importance of the active research methodology that engages the researcher/expert in the action and critical reflection process. Such a methodology can successfully underlie the formulation of accurate recommendations.
Before and during the COVID-19 Pandemic, Physical Fitness Association with Mental Health among Higher Education Students: A Multi-Group Analysis Model
Authors: Elshaer Ibrahim A. , Zayed Mohamed A.
Published: November 2022

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), created a significant problem people’s health around the world. The mental and physical health of entire populations has been negatively impacted due to the introduction of several restriction methods. Maintaining a specific physical activity and fitness level is crucial given the pandemic situation. The connection between physical fitness and mental health has recently received growing attention. In contrast to the message from physiological research, which lauds the general benefits of fitness for physical health, the corresponding psychological literature reveals a more complex relationship. This paper outlines the research evidence, focusing on the relationship between physical fitness and depression, anxiety, and stress before and during the COVID-19 pandemic. Data were obtained from 390 higher education students (measuring their perception before and during the pandemic). They were analyzed by a structural equation modeling multi-group analysis to detect the variance in the test relationship before and during the COVID-19 pandemic. Theoretical and empirical implications are also discussed.
Socio-Economic Factors Affecting Member’s Satisfaction towards National Health Insurance: An Evidence from the Philippines
Authors: Ong Ardvin Kester S. , Prasetyo Yogi Tri , Tayao Kate Nicole M. , Mariñas Klint Allen , Ayuwati Irene Dyah , Nadlifatin Reny , Persada Satria Fadil
Published: November 2022

The National Health Insurance, “PhilHealth”, is the healthcare provider for Filipino citizens in the Philippines. The study focused on determining the effects of members’ satisfaction with PhilHealth among Filipino members. The study utilized 10 latent variables from the integrated Service Quality (SERVQUAL) and Expectation-Confirmation Theory (ECT). There are 500 respondents that are used and analyzed through Structural Equation Modeling (SEM) and a Deep Learning Neural Network (DLNN). Utilizing SEM, it was revealed that Reliability, Responsiveness, Socio-Economic Factors, Expectation, Perceived Performance, Confirmation of Beliefs, and Members’ Satisfaction are significant factors in the satisfaction of PhilHealth members. Utilizing DLNN, it was found that Expectation (EX) is the most significant factor, and it is consistent with the results of the SEM. The government can use the findings of this study for the improvement of PhilHealth. The framework that is used for the analysis can be extended and can apply to future research with regard to its provided services. The overall results, framework, and concept utilized may be applied by other service industries worldwide.
Urbanization Impact on Regional Sustainable Development: Through the Lens of Urban-Rural Resilience
Authors: Shi Chenchen , Zhu Xiaoping , Wu Haowei , Li Zhihui
Published: November 2022

The urban–rural system is an economically, socially, and environmentally interlinked space, which requires the integration of industry, space, and population. To achieve sustainable and coordinated development between urban and rural systems, dynamic land use change within the urban–rural system and the ecological and social consequences need to be clarified. This study uses system resilience to evaluate such an impact and explores the impact of land use change, especially land conversion induced by urbanization on regional development through the lens of urban–rural resilience. The empirical case is based on the Beijing-Tianjin-Hebei Urban Agglomeration (BTHUA) in China from 2000 to 2020 when there was rapid urbanization in this region. The results show that along with urbanization in the BTHUA, urban–rural resilience is high in urban core areas and low in peripheral areas. From the urban core to the rural outskirts, there is a general trend that comprehensive resilience decreases with decreased social resilience and increased ecological resilience in this region. Specifically, at the city level, comprehensive resilience decreases sharply from the urban center to its 3–5 km buffer zone and then remains relatively stable in the rural regions. A similar trend goes for social resilience at the city level, while ecological resilience increases sharply from the urban center to its 1–3 km buffer zone, and then remains relatively stable in the rural regions in this region, except for cities in the west and south of Hebei. This study contributes to the conceptualization and measurement of urban–rural resilience in the urban–rural system with empirical findings revealing the impact of rapid urbanization on urban–rural resilience over the last twenty years in the BTHUA in China. In addition, the spatial heterogeneity results could be used for policy reference to make targeted resilience strategies in the study region.
Study Regarding the Optimal Dimension of Intraoral Bitewing Radiographs in Patients with Primary Dentition
Authors: Diéguez-Pérez Montserrat , Lacalle-Muñoz de Cuerva Concepción , Costa-Ferrer Fernando , Muñoz-Corcuera Marta
Published: November 2022

The aim of this study was to determine the optimum dimensions of a radiographic plate to allow correct visualization of dental tissues and correct fit in the oral cavity of children with deciduous dentition. A quasi-experimental clinical study was carried out in children of both sexes aged between 3 and 5 years. The study variables were the complete visualization of the dental structures, the surveillance of ischemia on soft tissues, stimulation of the gag reflex, and acceptance of the radiographic plate by the pediatric patient through a validated visual analogue scale that measures anxiety. The data obtained were subjected to a descriptive and comparative statistical analysis carried out for both study phases. A total of 80 children participated in the study. The optimal dimensions obtained for the radiographic plate were 19.5 mm in height and 27.3 mm in width. Visualization of the dental tissues during both phases was not statistically significant (p = 0.412). However, there were statistically significant differences regarding the presence of ischemia, gag reflex, and child rejection (p < 0.001). A smaller radiographic plate allows correct visualization of the coronal dental tissues without causing rejection, ischemia, or gag reflex in patients in the deciduous dentition.
Enhanced Tooth Region Detection Using Pretrained Deep Learning Models
Authors: Al-Sarem Mohammed , Al-Asali Mohammed , Alqutaibi Ahmed Yaseen , Saeed Faisal
Published: November 2022

The rapid development of artificial intelligence (AI) has led to the emergence of many new technologies in the healthcare industry. In dentistry, the patient’s panoramic radiographic or cone beam computed tomography (CBCT) images are used for implant placement planning to find the correct implant position and eliminate surgical risks. This study aims to develop a deep learning-based model that detects missing teeth’s position on a dataset segmented from CBCT images. Five hundred CBCT images were included in this study. After preprocessing, the datasets were randomized and divided into 70% training, 20% validation, and 10% test data. A total of six pretrained convolutional neural network (CNN) models were used in this study, which includes AlexNet, VGG16, VGG19, ResNet50, DenseNet169, and MobileNetV3. In addition, the proposed models were tested with/without applying the segmentation technique. Regarding the normal teeth class, the performance of the proposed pretrained DL models in terms of precision was above 0.90. Moreover, the experimental results showed the superiority of DenseNet169 with a precision of 0.98. In addition, other models such as MobileNetV3, VGG19, ResNet50, VGG16, and AlexNet obtained a precision of 0.95, 0.94, 0.94, 0.93, and 0.92, respectively. The DenseNet169 model performed well at the different stages of CBCT-based detection and classification with a segmentation accuracy of 93.3% and classification of missing tooth regions with an accuracy of 89%. As a result, the use of this model may represent a promising time-saving tool serving dental implantologists with a significant step toward automated dental implant planning.
Personal Goals, Barriers to Self-Management and Desired mHealth Application Features to Improve Self-Care in Multi-Ethnic Asian Patients with Type 2 Diabetes: A Qualitative Study
Authors: Yoon Sungwon , Kwan Yu Heng , Phang Jie Kie , Tan Wee Boon , Low Lian Leng
Published: November 2022

(1) Introduction: The ubiquity of mobile phones suggests the potential of mobile health applications to reach patients with type 2 diabetes and engage them to improve self-care. This study aimed to explore personal goals, barriers to self-management and desired mobile health application features to improve self-care among multi-ethnic Asian patients with type 2 diabetes. (2) Methods: We conducted semi-structured interviews with patients with type 2 diabetes (n = 29). Patients were recruited from a multi-disciplinary center for diabetes and metabolism in Singapore, using a purposive sampling strategy. Various visual materials, collated from existing mobile health application features, were used to facilitate the discussion. Interviews were transcribed verbatim and thematically analyzed. (3) Results: A total of 29 patients participated in 11 focus group discussions or one-on-one interviews. Personal goals for self-management were centered around short-term outcome expectancy, such as better glucose control and a reduced number of medications. Self-management was hampered by competing priorities and limited healthy food options when at work, while a lack of tailored advice from healthcare providers further diminished competence. The desired mobile health app features to improve self-care behaviors included quantifiable goal-setting, personalized nudges based on tracked data, built-in resources from credible sources, in-app social support through virtual interaction with peers and healthcare providers, technology-driven novel data logging and user-defined nudges. (4) Conclusions: We identified a set of app features that may foster motivation to engage in lifestyle modification for patients with T2DM. The findings serve to inform the design of artificial intelligence-enabled mobile health application intervention aimed at improving diabetes self-care.
Microbiologically Influenced Corrosion of Q235 Carbon Steel by Ectothiorhodospira sp.
Authors: Qi Hong , Wang Yingsi , Feng Jin , Peng Ruqun , Shi Qingshan , Xie Xiaobao
Published: November 2022

The biological sulfur cycle is closely related to iron corrosion in the natural environment. The effect of the sulfur-oxidising bacterium Ectothiorhodospira sp., named PHS-Q, on the metal corrosion behaviour rarely has been investigated. In this study, the corrosion mechanism of Q235 carbon steel in a PHS-Q-inoculated medium is discussed via the characterization of the morphology and the composition of the corrosion products, the measurement of local corrosion and the investigation of its electrochemical behaviour. The results suggested that, initially, PHS-Q assimilates sulfate to produce H2S directly or indirectly in the medium without sulfide. H2S reacts with Fe2+ to form an inert film on the coupon surface. Then, in localised areas, bacteria adhere to the reaction product and use the oxidation of FeS as a hydrogen donor. This process leads to a large cathode and a small anode, which incurs pitting corrosion. Consequently, the effect of PHS-Q on carbon steel corrosion behaviour is crucial in an anaerobic environment.
Effect of Gestational Pesticide Exposure on the Child’s Respiratory System: A Narrative Review
Authors: Ventura-Miranda María Isabel , Fernández-Medina Isabel María , Guillén-Romera Eulalia , Ortíz-Amo Rocío , Ruíz-Fernández María Dolores
Published: November 2022

Background: In recent years, concern has arisen worldwide about the potential adverse effects that could result from early-life exposure to pesticides. Asthma, bronchitis, and persistent cough in children have been linked to gestational exposure to pesticides. The respiratory effects of gestational exposure to pesticides are controversial. The aim of this study was to determine the relationship between pesticide exposure in pregnant women and its effect on the respiratory system of their children. Methods: A narrative review was carried out by means of a search in the main databases. Results: Findings of studies confirmed the effects of pesticides on the child’s health. These substances cross the placenta and become transmitters of exposure to the individual at the most sensitive stage of her development. Conclusions: Chronic exposure to pesticides in fetuses is associated with chronic respiratory symptoms and disease.
Efficacy of Adductor Canal Block on Medial Knee Pain in Patients with Knee Osteoarthritis: A Randomized Single-Blind Placebo-Controlled Study
Authors: Kim Ki-Yong , Huh Yool-Gang , Ma Sang Hyeok , Yoon Jong Hyeon , Jeong Kil-Yong , Park Do Young , Yoon Seung-Hyun
Published: November 2022

Background: This study aimed to confirm the efficacy of ultrasound-guided adductor canal block (ACB) as a treatment option for medial knee pain caused by knee osteoarthritis (KOA). Methods: In total, 31 participants with medial knee pain due to KOA were randomized to either the ACB (ultrasound-guided ACB, n = 15) or placebo group (1 mL of 1% lidocaine, n = 16). The primary outcome was a numerical rating scale (NRS) for knee pain intensity comparing before and 4 weeks after injection. The secondary outcomes were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), average daily number of analgesics consumed, average daily opioid consumption, and Timed Up and Go (TUG) test results before and 4 weeks after injection. Results: Participants’ baseline characteristics were not significantly different between the groups, except for age. At 4 weeks post-injection, the NRS score in the ACB group significantly improved compared to that in the placebo group (p = 0.009). However, the WOMAC, average daily number of analgesics consumed, average daily opioid consumption, and TUG test results did not show significant differences. Conclusion: ACB can be an effective treatment for reducing medial knee pain in patients with KOA.
Assessment of the Prevalence of Alcoholic Beverage Consumption and Knowledge of the Impact of Alcohol on Health in a Group of Polish Young Adults Aged 18–35: A Cross-Sectional Study
Authors: Wysokińska Martyna , Kołota Aleksandra
Published: November 2022

Alcoholic beverages are widely consumed worldwide, especially by young adults. Their excessive consumption is associated with numerous health, social and financial damages. The level of knowledge of young adults about the health effects of consuming alcoholic beverages is low, and research in this area is conducted on small, unrepresentative groups. This cross-sectional study aimed to assess the prevalence of alcoholic beverage consumption and the level of knowledge about the impact of ethyl alcohol on health in a group of people aged 18–35. The survey results indicate that the majority of respondents regularly consume alcoholic beverages (94.6%), and they are at a low risk of excessive consumption (p < 0.0001). The most frequently chosen alcoholic beverage in the studied group was beer, and the least chosen one was vodka. The main motive for reaching for alcoholic beverages was the desire to improve mood. Respondents did not indicate significant changes in alcohol consumption during the COVID-19 pandemic, but participants in the high-risk group more often indicated an increase in alcohol consumption (p = 0.0025). The analysis of the level of knowledge showed that the participants in the study had an average or low level of knowledge about the effects of ethanol on health, with no significant relationships between the study groups. The obtained results indicate a strong need for the continuous education of young people on the effects of the excessive consumption of alcoholic beverages on the body, with particular emphasis on the consequences of using alcohol as a mood-enhancing agent.
Biochemical and Behavioural Alterations Induced by Arsenic and Temperature in Hediste diversicolor of Different Growth Stages
Authors: Valente Pedro , Cardoso Paulo , Giménez Valéria , Silva Marta Sofia Salvador , Sá Carina , Figueira Etelvina , Pires Adília
Published: November 2022

Contamination with Arsenic, a toxic metalloid, is increasing in the marine environment. Additionally, global warming can alter metalloids toxicity. Polychaetes are key species in marine environments. By mobilizing sediments, they play vital roles in nutrient and element (including contaminants) cycles. Most studies with marine invertebrates focus on the effects of metalloids on either adults or larvae. Here, we bring information on the effects of temperature increase and arsenic contamination on the polychaete Hediste diversicolor in different growth stages and water temperatures. Feeding activity and biochemical responses—cholinesterase activity, indicators of cell damage, antioxidant and biotransformation enzymes and metabolic capacity—were evaluated. Temperature rise combined with As imposed alterations on feeding activity and biochemical endpoints at different growth stages. Small organisms have their antioxidant enzymes increased, avoiding lipid damage. However, larger organisms are the most affected class due to the inhibition of superoxide dismutase, which results in protein damage. Oxidative damage was observed on smaller and larger organisms exposed to As and temperature of 21 °C, demonstrating higher sensibility to the combination of temperature rise and As. The observed alterations may have ecological consequences, affecting the cycle of nutrients, sediment oxygenation and the food chain that depends on the bioturbation of this polychaete.
Association between Sleep and Suicidal Ideation in Chinese Undergraduate Students
Authors: Wu Ran , Wang Chun-Ying , Wang Feng , Wang Yu-Jing , Zhu Hong , Wang Guang-Hai , Jiang Chun-Lei
Published: November 2022

Suicide is an important global public health issue, which deserves more attention. This study aims to examine the relative independent relationship between suicide ideation and subjective sleep quality, sleep hygiene, and insomnia symptoms in undergraduate students in China. This population-based study included 2379 undergraduate students aged 18–26, randomly recruited from three public universities in Shanghai. The participants completed four questionnaires: the Pittsburgh Sleep Quality Index; Sleep Hygiene Practice Scale; Insomnia Severity Index; and the Symptom Checklist 90 (specifically the depression and anxiety dimensions and Q15-suicide ideation). The results of Spearman’s correlation analysis indicate that poor sleep quality, short sleep duration, poor sleep hygiene, and insomnia symptoms were all associated with suicidal ideation in undergraduate students. However, according to the results of the hierarchical linear regression, no experience of sharing a bedroom at home, poor relationship with roommates, short sleep duration, sleep medicine use, and good daytime function were related to suicidal ideation, after controlling for the symptoms of depression and anxiety, which may be important in the identification of suicidal ideation. Sleep problems are highly discoverable and modifiable, and have a low sense of shame, therefore, sleep interventions for individuals with suicidal ideation and poor sleep quality may be an efficient and effective approach to suicide prevention.
Holidays Abroad and the Eating Behavior of the Inhabitants of Poland
Authors: Mazurek-Kusiak Anna Katarzyna , Kobyłka Agata , Korcz Natalia , Soroka Andrzej
Published: November 2022

A hotel is interested that the guest buys from it not only accommodation, but also catering services, preferably an all-inclusive option. However, many tourists choose only accommodation or accommodation with breakfast, and dinners and other things are purchased outside the place of accommodation. Therefore, it is important to know the eating behavior of tourists, and what hotels must do to make guests want to use food services at the place of accommodation. The purpose of this article is to show the reasons for not buying full meals at hotels during vacations by the inhabitants of Poland. The study used the diagnostic survey method with the help of the direct survey technique. A proprietary survey questionnaire was developed. The direct survey was conducted among 3071 tourists across the country. The study was conducted in 2019–2020. For data analysis, a discriminant function was chosen to examine the differences between groups based on a set of selected independent variables. When buying tourist holidays in travel agencies, 32.40% of Poles bought the all-inclusive option, 33.15% bought breakfast and dinner, 12.47% bought breakfast only, while 21.98%, bought accommodation without any food. For tourists who did not buy any meals at the hotel, the most important factors for eating out were mainly unwillingness to adapt to the hours of serving meals at the place of accommodation, and the desire to control the quality of raw materials needed for preparation of individual dishes. Among hotel guests who only had breakfast at the hotel, the main reasons for eating lunch and dinner outside of the hotel were the desire to try local dishes in regional restaurants, to get to know different restaurants, and to eat meals made entirely of ecological materials. A big barrier to buying meals in a hotel was the lack of offering dietetic dishes or their too high price. Older people dined out because of the lack of dietary dishes or their too high price and because they look for restaurants that serve meals prepared from ecological ingredients. Younger people, on the other hand, did not dine at the hotel because they did not want the hours of serving meals at the hotel to limit their sightseeing in the city and surroundings.
Canada Goldenrod Invasion Regulates the Effects of Soil Moisture on Soil Respiration
Authors: Xu Sixuan , Li Kexin , Li Guanlin , Hu Zhiyuan , Zhang Jiaqi , Iqbal Babar , Du Daolin
Published: November 2022

Canada goldenrod (Solidago canadensis L.) is considered one of the most deleterious and invasive species worldwide, and invasion of riparian wetlands by S. canadensis can reduce vegetation diversity and alter soil nutrient cycling. However, little is known about how S. canadensis invasion affects soil carbon cycle processes, such as soil respiration, in a riparian wetland. This study was conducted to investigate the effects of different degrees of S. canadensis invasion on soil respiration under different moisture conditions. Soil respiration rate (heterotrophic and autotrophic respiration) was measured using a closed-chamber method. S. canadensis invasion considerably reduced soil respiration under all moisture conditions. The inhibition effect on autotrophic respiration was higher than that on heterotrophic respiration. The water level gradient affects the soil autotrophic respiration, thereby affecting the soil respiration rate. The changes in soil respiration may be related to the alteration in the effective substrate of the soil substrate induced by the invasion of S. canadensis. While the effects of S. canadensis invasion were regulated by the fluctuation in moisture conditions. Our results implied that S. canadensis invasion could reduce the soil respiration, which further potentially affect the carbon sequestration in the riparian wetlands. Thus, the present study provided a reference for predicting the dynamics of carbon cycling during S. canadensis invasion and constituted a scientific basis for the sustainable development and management of riparian wetlands invaded by alien plants.
Local Welfare Systems and Health Inequalities: The Effects of Institutional Overlapping and Local Variations
Authors: Rodríguez-García María Jesús , Navarro-Yáñez Clemente J. , Zapata-Moya Ángel R.
Published: November 2022

A growing research agenda shows the importance of local welfare systems in understanding socio-spatial inequalities in health. Welfare services provided by local governments overlap with those provided by other levels of government. Thus, differences in the provision of welfare services between municipalities could explain differences in residents’ health, moderating the magnitude of health inequalities if local governments deploy actions capable of positively influencing the social determinants of health. This article attempts to analyse this idea in the Spanish case, exploring the influence of local policies according to the orientation of municipal spending on three indicators of the population’s health status: self-perceived health, healthy practices and activity limitations due to health problems. A multilevel cross-sectional study was designed using information from two waves of the 2006–2007 and 2011–2012 National Health Survey for the population aged 15 years and older (N = 31,378) residing in Spanish municipalities of 20,000 inhabitants or over (N = 373). The results show that the magnitude of inequalities in self-perceived health, in the adoption of healthy practices and in daily activity limitations by social class are smaller as municipalities” spending was oriented towards policy areas considered as redistributive. Therefore, the proposed institutional overlap thesis could help understand the role of subnational governments on the magnitude of health inequalities, as well as in comparative analysis between countries with institutional systems in which local governments have a greater or lesser capacity to provide welfare services.
Psychometric Properties of the Chinese Version of the Oxford Participation and Activities Questionnaire in People with Stroke
Authors: Ng Shamay S. M. , Ho Lily Y. W. , Chan Nga-Huen , Liu Tai-Wa , So Billy
Published: November 2022

The Oxford Participation and Activities Questionnaire was developed for generic use in the assessment of participation and activity levels. However, it is not available in Chinese and has not been tested in the stroke population. The Oxford Participation and Activities Questionnaire was translated into Chinese and culturally adapted. Its psychometric properties were examined in 100 people with stroke. The participation and activity levels of people with stroke and healthy people were also compared. Content validity and internal consistency (Cronbach’s α = 0.86–0.91) were excellent. The test–retest reliability (intraclass correlation coefficient = 0.91–0.94) was also satisfactory. The standard error of the measurement was 4.10–5.31, and the minimal detectable change was 11.37–14.71. Convergent and divergent validity were supported by hypothesis testing. The instrument had a five-factor structure without a ceiling effect. Its routine activity and social engagement scores discriminated people with stroke from healthy people. In conclusion, the Chinese version of the Oxford Participation and Activities Questionnaire is reliable and valid for assessing participation and activity levels in the stroke population.
Factors Influencing Use of Fitness Apps by Adults under Influence of COVID-19
Authors: Guo Yanlong , Ma Xueqing , Chen Denghang , Zhang Han
Published: November 2022

During the coronavirus disease 2019 (COVID-19) pandemic, many countries imposed restrictions and quarantines on the population, which led to a decrease in people’s physical activity (PA) and severely damaged their mental health. As a result, people engaged in fitness activities with the help of fitness apps, which improved their resistance to the virus and reduced the occurrence of psychological problems, such as anxiety and depression. However, the churn rate of fitness apps is high. As such, our purpose in this study was to analyze the factors that influence the use of fitness apps by adults aged 18–65 years in the context of COVID-19, with the aim of contributing to the analysis of mobile fitness user behavior and related product design practices. We constructed a decision target program model using the analytic hierarchy process (AHP), and we analyzed and inductively screened 11 evaluation indicators, which we combined with an indicator design questionnaire. We distributed 420 questionnaires; of the respondents, 347 knew about or used fitness apps. Among these 347, we recovered 310 valid questionnaires after removing invalid questionnaires with a short completion time, for an effective questionnaire recovery rate of 89.33%. We used the AHP and entropy method to calculate and evaluate the weight coefficient of each influencing factor and to determine an influencing factor index. Our conclusions were as follows: first, the effect of perceived usefulness on the use of fitness apps by the study groups was the most notable. Second, personal motivation and perceived ease of use considerably influenced the adult group’s willingness to use fitness apps. Finally, the perceived cost had relatively little effect on the use of fitness apps by adults, and the study group was much more concerned with the privacy cost than the expense cost.
Prevalence of Depression, Anxiety, and Stress in Junior High School Students in Guadalajara, Mexico: A Cross-Sectional Survey Study
Authors: Maciel-Saldierna Manuel , Elizondo-Hernández Emmanuel , Cervantes-Guevara Gabino , Cervantes-Pérez Enrique , Cervantes-Cardona Guillermo Alonso , Guzmán-Ramírez Bertha Georgina , Brancaccio-Pérez Irma Valeria , Chejfec-Ciociano Jonathan Matías , Guzmán-Ruvalcaba Mario Jesús , Cifuentes-Andrade Luis Rodrigo , Cueto-Valadez Andrea Estefanía , Cueto-Valadez Tania Abigail , Ibarra-Camargo Silvia Alejandra , Mellado-Tellez Mel Paul , Barbosa-Camacho Francisco José , Fuentes-Orozco Clotilde , González-Ojeda Alejandro
Published: November 2022

Confinement and a lack of social interaction are associated with depressive symptoms, low self-esteem, and suicidal thoughts. We report the results of a cross-sectional survey of 1414 junior high school students. The aim was to evaluate the prevalence of depression, anxiety, and stress in Guadalajara, Mexico, during the COVID-19 pandemic. Mean scores on the validated Spanish version of the Depression, Anxiety, and Stress Scale (DASS-21) were found to be 6.15 ± 5.6 for depression, 5.8 ± 5.2 for anxiety, and 8.08 ± 5.3 for stress. Female students scored higher in all three conditions (p < 0.001). Students who had relatives infected with COVID-19 showed significantly more anxiety than those who did not (p < 0.004). Although certain demographic groups are at higher risk of manifesting depression, anxiety, and stress, the student population has also been affected by the global impact of the pandemic.
Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders
Authors: Lin Pei-Yun , Stern Arnold , Peng Hsin-Hsin , Chen Jiun-Han , Yang Hung-Chi
Published: November 2022

The intestinal epithelium forms a physical barrier assembled by intercellular junctions, preventing luminal pathogens and toxins from crossing it. The integrity of tight junctions is critical for maintaining intestinal health as the breakdown of tight junction proteins leads to various disorders. Redox reactions are closely associated with energy metabolism. Understanding the regulation of tight junctions by cellular metabolism and redox status in cells may lead to the identification of potential targets for therapeutic interventions. In vitro and in vivo models have been utilized in investigating intestinal barrier dysfunction and in particular the free-living soil nematode, Caenorhabditis elegans, may be an important alternative to mammalian models because of its convenience of culture, transparent body for microscopy, short generation time, invariant cell lineage and tractable genetics.
Human Lung Mast Cells: Therapeutic Implications in Asthma
Authors: Poto Remo , Criscuolo Gjada , Marone Gianni , Brightling Chris E. , Varricchi Gilda
Published: November 2022

Mast cells are strategically located in different compartments of the lung in asthmatic patients. These cells are widely recognized as central effectors and immunomodulators in different asthma phenotypes. Mast cell mediators activate a wide spectrum of cells of the innate and adaptive immune system during airway inflammation. Moreover, these cells modulate the activities of several structural cells (i.e., fibroblasts, airway smooth muscle cells, bronchial epithelial and goblet cells, and endothelial cells) in the human lung. These findings indicate that lung mast cells and their mediators significantly contribute to the immune induction of airway remodeling in severe asthma. Therapies targeting mast cell mediators and/or their receptors, including monoclonal antibodies targeting IgE, IL-4/IL-13, IL-5/IL-5Rα, IL-4Rα, TSLP, and IL-33, have been found safe and effective in the treatment of different phenotypes of asthma. Moreover, agonists of inhibitory receptors expressed by human mast cells (Siglec-8, Siglec-6) are under investigation for asthma treatment. Increasing evidence suggests that different approaches to depleting mast cells show promising results in severe asthma treatment. Novel treatments targeting mast cells can presumably change the course of the disease and induce drug-free remission in bronchial asthma. Here, we provide an overview of current and promising treatments for asthma that directly or indirectly target lung mast cells.
Bcl-2 Family Members Bcl-xL and Bax Cooperatively Contribute to Bortezomib Resistance in Mantle Cell Lymphoma
Authors: Luanpitpong Sudjit , Janan Montira , Yosudjai Juthamas , Poohadsuan Jirarat , Chanvorachote Pithi , Issaragrisil Surapol
Published: November 2022

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with poor prognosis, due to the inevitable development of drug resistance. Despite being the first-in-class proteasome inhibitor for relapsed/refractory MCL, resistance to bortezomib (BTZ) in MCL patients remains a major hurdle of effective therapy, and relapse following BTZ is frequent. Understanding the mechanisms underlying BTZ resistance is, therefore, important for improving the clinical outcome and developing novel therapeutic strategies. Here, we established de novo BTZ-resistant human MCL-derived cells with the highest resistance index of 300-fold compared to parental cells. We provided compelling evidence that both Bcl-xL and Bax are key mediators in determining BTZ sensitivity in MCL cells. Overexpression of antiapoptotic Bcl-xL and depletion of proapoptotic Bax cooperatively protected MCL cells against BTZ-induced apoptosis, causing acquired BTZ resistance, likely by tilting the balance of Bcl-2 family proteins toward antiapoptotic signaling. Bioinformatics analyses suggested that high BCL2L1 (encoded Bcl-xL) and low BAX were, in part, associated with poor prognosis of MCL patients, e.g., when combined with low OGT, which regulates cellular O-GlcNAcylation. Our findings support recent strategies in small molecule drug discovery co-targeting antiapoptotic Bcl-2 family proteins using BH3 mimetics and Bax using Bax activators to overcome cancer drug resistance.
The Four Homeostasis Knights: In Balance upon Post-Translational Modifications
Authors: Pieroni Stefania , Castelli Marilena , Piobbico Danilo , Ferracchiato Simona , Scopetti Damiano , Di-Iacovo Nicola , Della-Fazia Maria Agnese , Servillo Giuseppe
Published: November 2022

A cancer outcome is a multifactorial event that comes from both exogenous injuries and an endogenous predisposing background. The healthy state is guaranteed by the fine-tuning of genes controlling cell proliferation, differentiation, and development, whose alteration induces cellular behavioral changes finally leading to cancer. The function of proteins in cells and tissues is controlled at both the transcriptional and translational level, and the mechanism allowing them to carry out their functions is not only a matter of level. A major challenge to the cell is to guarantee that proteins are made, folded, assembled and delivered to function properly, like and even more than other proteins when referring to oncogenes and onco-suppressors products. Over genetic, epigenetic, transcriptional, and translational control, protein synthesis depends on additional steps of regulation. Post-translational modifications are reversible and dynamic processes that allow the cell to rapidly modulate protein amounts and function. Among them, ubiquitination and ubiquitin-like modifications modulate the stability and control the activity of most of the proteins that manage cell cycle, immune responses, apoptosis, and senescence. The crosstalk between ubiquitination and ubiquitin-like modifications and post-translational modifications is a keystone to quickly update the activation state of many proteins responsible for the orchestration of cell metabolism. In this light, the correct activity of post-translational machinery is essential to prevent the development of cancer. Here we summarize the main post-translational modifications engaged in controlling the activity of the principal oncogenes and tumor suppressors genes involved in the development of most human cancers.