bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-Functional Properties of Bee Pollen: The Case of “Bee Pollen Yoghurt”
Authors: Karabagias Ioannis K. , Karabagias Vassilios K. , Gatzias Ilias , Riganakos Kyriakos A.
Published: November 2018

The objectives of the present work were: (a) to characterize bee pollen from the region of Epirus in terms of biofunctional activity parameters as assessed by (i) the determination of specific polyphenols using high performance liquid chromatography electrospray ionization mass spectrometry (HPLC/ESI-MS), (ii) antioxidant capacity (DPPH assay), and (iii) total phenolic content (Folin-Ciocalteu assay), and (b) to prepare yoghurts from cow, goat, and sheep milk supplemented with different concentrations of grounded bee pollen (0.5, 1.0, 2.5 and 3.0%, w/v), and study afterwards the trend in antioxidant capacity and total phenolic content along with product’s sensory properties. Results showed that bee pollen ethanolic extracts are a rich source of phytochemicals based on the high total phenolic content and in vitro antioxidant activity that were monitored. The addition of grounded bee pollen in yoghurts resulted in a food matrix of a higher in vitro antioxidant capacity and total phenolic content, whereas it improved the yoghurt’s taste, odour, appearance, and cohesion; the latter indicates its beneficial use as a general food surface and interface material enhancer due to the possible formation of surface/interface active lipid-linked proteins. Based on the present findings, bee pollen yoghurt is proposed as a novel and costless functional food whereas it may comprise a research basis for food or material science in the scientific society of the future. Results were further supported by implementation of advanced chemometric analyses providing a full characterization of the product’s uniqueness.
Recursive Minimum Complex Kernel Risk-Sensitive Loss Algorithm
Authors: Qian Guobing , Luo Dan , Wang Shiyuan
Published: November 2018

The maximum complex correntropy criterion (MCCC) has been extended to complex domain for dealing with complex-valued data in the presence of impulsive noise. Compared with the correntropy based loss, a kernel risk-sensitive loss (KRSL) defined in kernel space has demonstrated a superior performance surface in the complex domain. However, there is no report regarding the recursive KRSL algorithm in the complex domain. Therefore, in this paper we propose a recursive complex KRSL algorithm called the recursive minimum complex kernel risk-sensitive loss (RMCKRSL). In addition, we analyze its stability and obtain the theoretical value of the excess mean square error (EMSE), which are both supported by simulations. Simulation results verify that the proposed RMCKRSL out-performs the MCCC, generalized MCCC (GMCCC), and traditional recursive least squares (RLS).
MHD Mixed Convection and Entropy Generation in a Lid-Driven Triangular Cavity for Various Electrical Conductivity Models
Authors: Chamkha Ali , Selimefendigil Fatih , Oztop Hakan
Published: November 2018

In this study, effects of different electrical conductivity models for magneto- hydrodynamic mixed convection of nanofluids in a lid-driven triangular cavity was numerically investigated with a finite element method. Effects of Richardson number and Hartmann number on the convective heat transfer characteristics were analyzed for various electrical conductivity models of nanofluids. Average Nusselt number decreases for higher Hartmann and Richardson numbers. Discrepancies in the local and average heat transfer exist between different electrical conductivity models, which is higher for higher values of Richardson number and Hartmann number. The total entropy generation rate was found reduced with higher values of Richardson number and Hartmann number while discrepancies exist between various electrical conductivity models. When the magnetic field is imposed, different behaviors of entropy generation rate versus solid particle volume fraction curve is obtained and it is dependent upon the range of solid particle volume fraction.
Multi-Step Magnetization Process of Gd-Co/Co/Cu/Co Thermo-Sensitive Spin Valves
Authors: Svalov Andrei V. , Orue Iñaki , Kurlyandskaya Galina V.
Published: November 2018

Magnetic and magnetoresistive properties of the Gd-Co/Co/Cu/Co magnetic type multilayered sensitive spin valve were studied as a function of temperature. It is shown that the appearance of a non-collinear magnetic structure significantly affects the shape of the magnetoresistive hysteresis loop. The characteristic values of the critical field related to the appearance of non-collinear structure depend on the temperature of the spin valve. The obtained results can serve as a basis for the improvements of functional properties and expanding the application areas of magnetic multilayered sensitive elements of the spin valve type; for example, for precise determination of the position of the object.
An Efficient SC-FDM Modulation Technique for a UAV Communication Link
Authors: Atoev Sukhrob , Kwon Oh-Heum , Lee Suk-Hwan , Kwon Ki-Ryong
Published: November 2018

Since the communication link of an unmanned aerial vehicle (UAV) and its reliability evaluation represent an arduous field, we have concentrated our work on this topic. The demand regarding the validity and reliability of the communication and data link of UAV is much higher since the environment of the modern battlefield is becoming more and more complex. Therefore, the communication channel between the vehicle and ground control station (GCS) should be secure and provide an efficient data link. In addition, similar to other types of communications, the data link of a UAV has several requirements such as long-range operation, high efficiency, reliability, and low latency. In order to achieve an efficient data link, we need to adopt a highly efficient modulation technique, which leads to an increase in the flight time of the UAV, data transmission rate, and the reliability of the communication link. For this purpose, we have investigated the single-carrier frequency division multiplexing (SC-FDM) modulation technique for a UAV communication system. The results obtained from the comparative study demonstrate that SC-FDM has better performance than the currently used modulation technique for a UAV communication link. We expect that our proposed approach can be a remarkable framework that will help drone manufacturers to establish an efficient UAV communication link and extend the flight duration of drones, especially those being used for search and rescue operations, military tasks, and delivery services.
Cross-Border Energy Exchange and Renewable Premiums: The Case of the Iberian System
Authors: Roldan-Fernandez Juan Manuel , Gómez-Quiles Catalina , Merre Adrien , Burgos-Payán Manuel , Riquelme-Santos Jesús Manuel
Published: November 2018

In 2002, the European Union set a target of 10% electricity interconnection capacity for 2020: a target that has been further extended to 15% by 2030. Cross-border interconnection of regional/national electricity systems will allow the EU to enhance its security of supply and to integrate more renewables into energy markets. Although the EU has a common renewable directive, every Member State has its own renewable support policy. For the case of Spain, consumers pay the renewable premium in their electricity bills; however, consumers would not be overburdened if premiums were counter-balanced with the energy-cost reduction due to the merit-order effect of renewables. When two markets are interconnected, the energy exchange through the interconnection yields certain expected rent transfers due to the market rules. However, this exchange is also accompanied by other unforeseen rent transfers related to the regional/national policies on renewables. To the authors’ knowledge, the identification and quantification of these indirect rent transfers has not been previously addressed. This paper analyses and quantifies how the premiums on regional/national renewables are distributed between neighbouring countries through cross-border exchanges. The analysis focuses on the Iberian/Spanish system and its neighbours, although the methodology could be extended to other systems. To this end, data on the market and premiums has been considered, as well as the exchanges between France, Spain, Portugal, and Morocco, for the years 2015–2017. The main finding of this work is that the Spanish system, due to the lack of a coordinated/harmonized renewable premium policy, has been “importing” about 40 M€/year of renewable premium from France and 17 M€/year from Portugal while “exporting” about 66 M€/year towards the Moroccan systems.
Advanced Methodology for the Optimal Sizing of the Energy Storage System in a Hybrid Electric Refuse Collector Vehicle Using Real Routes
Authors: Cortez Ernest , Moreno-Eguilaz Manuel , Soriano Francisco
Published: November 2018

This paper presents a new methodology for optimal sizing of the energy storage system ( E S S ), with the aim of being used in the design process of a hybrid electric (HE) refuse collector vehicle ( R C V ). This methodology has, as the main element, to model a multi-objective optimisation problem that considers the specific energy of a basic cell of lithium polymer ( L i – P o ) battery and the cost of manufacture. Furthermore, optimal space solutions are determined from a multi-objective genetic algorithm that considers linear inequalities and limits in the decision variables. Subsequently, it is proposed to employ optimal space solutions for sizing the energy storage system, based on the energy required by the drive cycle of a conventional refuse collector vehicle. In addition, it is proposed to discard elements of optimal space solutions for sizing the energy storage system so as to achieve the highest fuel economy in the hybrid electric refuse collector vehicle design phase.
Experimental Study of Injection Parameters on the Performance of a Diesel Engine with Fischer–Tropsch Fuel Synthesized from Coal
Authors: Shi Jinhong , Wang Tie , Zhao Zhen , Yang Tiantian , Zhang Zhengwu
Published: November 2018

Experimental research was conducted on a turbo-charged, inter-cooling and common-rail diesel engine with Fischer–Tropsch fuel synthesized from Coal-to-liquid (CTL), in order to investigate the influence of different injection parameters on the combustion, emissions and efficiency characteristics of the engine. The results showed that the ignition point was advanced, the in-cylinder pressure and heat release rate increased as the injection timing advanced and the injection pressure increased. By comparing the peak in-cylinder pressure of 100 cycles for one sample, it was found that the coefficient variation (COV) remained under 2% throughout the tests and the combustion process remained stable. NOx emissions decreased with delayed injection timing and lower injection pressure. In contrast to NOx emissions, soot emissions were almost zero when the injection pressure was up to 143.5 MPa. The indicated thermal efficiency (ITE) showed no obvious change with different injection parameters, and remained under 40% in all the tests.
Hybrid Short-Term Load Forecasting Scheme Using Random Forest and Multilayer Perceptron
Authors: Moon Jihoon , Kim Yongsung , Son Minjae , Hwang Eenjun
Published: November 2018

A stable power supply is very important in the management of power infrastructure. One of the critical tasks in accomplishing this is to predict power consumption accurately, which usually requires considering diverse factors, including environmental, social, and spatial-temporal factors. Depending on the prediction scope, building type can also be an important factor since the same types of buildings show similar power consumption patterns. A university campus usually consists of several building types, including a laboratory, administrative office, lecture room, and dormitory. Depending on the temporal and external conditions, they tend to show a wide variation in the electrical load pattern. This paper proposes a hybrid short-term load forecast model for an educational building complex by using random forest and multilayer perceptron. To construct this model, we collect electrical load data of six years from a university campus and split them into training, validation, and test sets. For the training set, we classify the data using a decision tree with input parameters including date, day of the week, holiday, and academic year. In addition, we consider various configurations for random forest and multilayer perceptron and evaluate their prediction performance using the validation set to determine the optimal configuration. Then, we construct a hybrid short-term load forecast model by combining the two models and predict the daily electrical load for the test set. Through various experiments, we show that our hybrid forecast model performs better than other popular single forecast models.
Assessment of the Territorial Energy Security in the Context of Energy Systems Integration
Authors: Lisin Evgeny , Strielkowski Wadim , Chernova Veronika , Fomina Alena
Published: November 2018

Our paper tackles the timely and highly-debated issue of assessment of the level of energy security for Russia’s territorial entities. Our analysis is carried out from the perspective of economic and management threats to reliable power supply for consumers caused by the process of integration of energy systems and the expansion of market regulation mechanisms. In particular, we focus on the creation and integration of energy systems using a case study of the remote territorial entity represented by Russia’s Far Eastern region that present a topic of special interest with respect to the subject and the scope of this research. We define and build the methods that might be used for determining the economically justified level of energy security under the market economy conditions based on ensuring a balance of interests between territorial government bodies and territorial generating companies in the process of forming a strategy for the development of a territorial energy system. Our results clearly demonstrate that current electricity tariffs and prices for the end consumers at the remote territorial entities, such as the Russian Far Eastern region, pose a threat to energy security since they are underestimated due to social and political concerns and often lead to unprofitable power generation. We argue that political consideration aside, energy systems creation and integration should be made viable and sustainable not only in Russia, but also in other countries. Our outcomes show that a more reasonable energy tariff policy might be appropriate when relevant stakeholders and policy-makers attempt to create conditions for the advanced development of remote industrial areas.
Effect of Time on a Hierarchical Corn Skeleton-Like Composite of CoO@ZnO as Capacitive Electrode Material for High Specific Performance Supercapacitors
Authors: Kumar Yedluri Anil , Kim Hee-Je
Published: November 2018

CoO–ZnO-based composites have attracted considerable attention for the development of energy storage devices because of their multifunctional characterization and ease of integration with existing components. This paper reports the synthesis of CoO@ZnO (CZ) nanostructures on Ni foam by the chemical bath deposition (CBD) method for facile and eco-friendly supercapacitor applications. The formation of a CoO@ZnO electrode functioned with cobalt, zinc, nickel and oxygen groups was confirmed by X-ray diffraction (XRD) analysis, X-ray photoelectron spectroscopy (XPS), low and high-resolution scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. The as-synthesized hierarchical nanocorn skeleton-like structure of a CoO@ZnO-3h (CZ3h) electrode delivered a higher specific capacitance (Cs) of 1136 F/g at 3 A/g with outstanding cycling performance, showing 98.3% capacitance retention over 3000 cycles in an aqueous 2 M KOH electrolyte solution. This retention was significantly better than that of other prepared electrodes, such as CoO, ZnO, CoO@ZnO-1h (CZ1h), and CoO@ZnO-7h (CZ7h) (274 F/g, 383 F/g, 240 F/g and 537 F/g). This outstanding performance was attributed to the excellent surface morphology of CZ3h, which is responsible for the rapid electron/ion transfer between the electrolyte and the electrode surface area. The enhanced features of the CZ3h electrode highlight potential applications in high performance supercapacitors, solar cells, photocatalysis, and electrocatalysis.
Simulation of Convection–Diffusion Transport in a Laminar Flow Past a Row of Parallel Absorbing Fibers
Authors: Kirsch Vasily A. , Bildyukevich Alexandr V. , Bazhenov Stepan D.
Published: November 2018

A numerical simulation of the laminar flow field and convection–diffusion mass transfer in a regular system of parallel fully absorbing fibers for the range of Reynolds numbers up to Re = 300 is performed. An isolated row of equidistant circular fibers arranged normally to the external flow is considered as the simplest model for a hollow-fiber membrane contactor. The drag forces acting on the fibers with dependence on Re and on the ratio of the fiber diameter to the distance between the fiber axes, as well as the fiber Sherwood number versus Re and the Schmidt number, Sc, are calculated. A nonlinear regression formula is proposed for calculating the fiber drag force versus Re in a wide range of the interfiber distances. It is shown that the Natanson formula for the fiber Sherwood number as a function of the fiber drag force, Re, and Sc, which was originally derived in the limit of high Peclet numbers, is applicable for small and intermediate Reynolds numbers; intermediate and large Peclet numbers, where Pe = Re × Sc; and for sparse and moderately dense rows of fibers.
Food Safety Knowledge and Practices among Saudi Mothers
Authors: Ayaz Wafa O. , Priyadarshini Anushree , Jaiswal Amit K.
Published: November 2018

This study examines food safety knowledge and practices of mothers in Saudi Arabia. A total of 979 respondents participated in the study and completed a questionnaire that assessed their knowledge of food storage, food handling, usage, and maintenance of kitchen facilities, personal hygiene, and food poisoning. Results showed that mothers in Saudi Arabia had moderate knowledge of food storage (passing rate 64.9%) and usage and maintenance of kitchen facilities (passing rate 66.5%). While they had good knowledge of personal hygiene (passing rate 83.8%) and food poisoning (passing rate 78.5%), their knowledge with regard to food handling was poor (passing rate 30.4%). Results also highlighted that food safety knowledge and practices amongst mothers in Saudi Arabia improved with the level of education, while their age, employment status, monthly income, and number of children had no significant association with their food safety knowledge and practices. This research revealed the importance of education and that advance education and training program can further improve mothers’ food safety knowledge and practices and thereby result in reducing the risks of foodborne illnesses at homes.
The First- and Second-Order Fermi Acceleration Processes in BL Lacertae Objects
Authors: Kapanadze Bidzina
Published: November 2018

BL Lacertae objects constitute a rare class of active galactic nuclei with extreme observational features attributed to the Doppler-boosted emission from a relativistic jet, closely aligned to our line-of-sight. Their spectral energy distribution, extending over 17–19 orders of frequency from radio to the TeV energy range, is of non-thermal origin and shows a typical two-component structure. The lower-energy component, ranging from the radio to X-rays in the high-energy peaked BL Lacertae sources, is widely accepted to be a synchrotron radiation emitted by ultra-relativistic charged particles, to be initially accelerated via the Blandford–Znajek mechanism or magneto-hydrodynamic processes in the vicinity of the central super-massive black hole. However, the accelerated particles should lose the energy, sufficient for the emission of the keV-GeV photons, very quickly and the source can maintain its flaring state on the daily-weekly timescales only if some additional acceleration mechanisms are continuously at work. According to different studies and simulations, the particles can gain tremendous energies due to the propagation of relativistic shocks through the jet: By means of first-order Fermi mechanism at the shock front, or they undergo an efficient stochastic (second-order Fermi) acceleration close to the shock front, in the turbulent jet medium. Our intensive X-ray spectral study of TeV-detected, bright BL Lacertae objects (Mrk 421, 1ES 1959+650, Mrk 501) often show the signatures of the stochastic acceleration, while those related to the first-order Fermi process arefound relatively rarely. The TeV-undetected sources (1H 1516+660, BZB J1341+3959, BZB J1237+6258) mostly do not show the signatures of the efficient stochastic acceleration in their jets.
A New Porphyry Mo Mineralization at Aisymi-Leptokarya, South-Eastern Rhodope, North-East Greece: Geological and Mineralogical Constraints
Authors: Galanopoulos Evangelos , Voudouris Panagiotis , Mavrogonatos Constantinos , Spry Paul G. , Hart Craig , Melfos Vasilios , Zaccarini Federica , Alfieris Dimitrios
Published: November 2018

A new porphyry Mo prospect has been discovered in the Aisymi-Leptokarya area, along the southern margin of the Byala Reka–Kechros metamorphic dome, south-eastern (SE) Rhodope metallogenic zone. The study area is dominated by an Oligocene felsic dike complex, which hosts the porphyry Mo mineralization and intrudes into upper Eocene sandstones-marls and the Leptokarya monzodiorite pluton. The Aisymi-Leptokarya felsic dike complex displays a rhyodacitic to dacitic composition with post-collisional affinities. The porphyry Mo mineralization occurs in the form of porphyry-style quartz stockworks in the felsic dike complex associated with potassic alteration characterized by hydrothermal K-feldspar. The ore minerals consist mainly of pyrite, molybdenite, kesterite, bismuthinite and galena within both the stockwork and the rock matrix. Bulk ore analyses indicate enrichment in Mo (up to 215 ppm), Se (up to 29 ppm), Bi (up to 8 ppm) and Sn (up to 14 ppm) in the porphyry quartz veins. Late-stage, north-east (NE-) and north-west (NW-)trending milky quartz intermediate-sulfidation epithermal veins with base metals, crosscut previous vein generations and are characterized by Ag, Sn and Te anomalies. The Aisymi-Leptokarya porphyry Mo prospect is set in a back-arc geotectonic regime and shares similarities to other post-subduction porphyry molybdenum deposits elsewhere.
Spatiotemporal Assessment of Induced Seismicity in Oklahoma: Foreseeable Fewer Earthquakes for Sustainable Oil and Gas Extraction?
Authors: Hong Zhen , Moreno Hernan A. , Hong Yang
Published: November 2018

In this study we present a spatiotemporal analysis of the recent seismicity and industry-related wastewater injection activity in Oklahoma. A parsimonious predictive tool was developed to estimate the lagged effect of previous month’s injection volumes on subsequent regional seismic activity. Results support the hypothesis that the recent boom in unconventional oil and gas production and either the mitigation policies or the drop in oil prices (or both) are potentially responsible for the upsurge and reduction in the state’s seismic activity between 2006–2015 and 2016–2017, respectively. A cluster analysis reveals a synchronous migration pattern between earthquake occurrences and salt water injection with a predominant northwest direction during 2006 through 2017. A lagged cross-correlation analysis allows extracting a power law between expected number of quakes and weighted average monthly injection volumes with a coefficient of determination of R2 = 0.77. Such a relation could be used to establish “sustainable water injection limits” aiming to minimize seismicity to values comparable with several historically representative averages. Results from these analyses coincide on previously found sustainable limits of 5 to 6 million m3/month but expand to operations that could attain the same number through differential monthly planning. Findings could potentially be used for model intercomparison and regulation policies.
The Management of Older Adults with Pancreatic Adenocarcinoma
Authors: Ogden John R. , Xie Hao , Ma Wen Wee , Hubbard Joleen M.
Published: November 2018

Pancreatic cancer is the eleventh most common cancer, yet it is the third leading cause of mortality. It is also largely a disease of older adults, with the median age of 71 at diagnosis in the US, with <1% of diagnoses occurring prior to age 50. Current NCCN guidelines recommend surgery for localized disease, followed by adjuvant therapy and/or consideration of enrollment in a clinical trial. For metastatic disease, current guidelines recommend clinical trial enrollment or systemic chemotherapy based on results from the landmark ACCORD-11 and MPACT trials. However, these trials focused heavily on younger, more fit patients, with the ACCORD-11 trial excluding patients over age 75 and the MPACT trial having 92% of its patients with a Karnofsky performance score >80. This article summarizes the available evidence in current literature in regards to the best treatment options for older adults, who represent the majority of pancreatic cancer diagnoses.
Does Instruction of Oral Health Behavior for Workers Improve Work Performance?—Quasi-Randomized Trial
Authors: Toyama Naoki , Taniguchi-Tabata Ayano , Sawada Nanami , Sugiura Yoshio , Fukuhara Daiki , Uchida Yoko , Miyai Hisataka , Yokoi Aya , Mizutani Shinsuke , Ekuni Daisuke , Morita Manabu
Published: November 2018

Oral disease can cause economic loss due to impaired work performance. Therefore, improvement of oral health status and prevention of oral disease is essential among workers. The purpose of this study was to investigate whether oral health-related behavioral modification intervention influences work performance or improves oral health behavior and oral health status among Japanese workers. We quasi-randomly separated participants into the intervention group or the control group at baseline. The intervention group received intensive oral health instruction at baseline and a self-assessment every three months. Both groups received oral examinations and answered the self-questionnaire at baseline and at one-year follow-up. At follow-up, the prevalence of subjects who use fluoride toothpastes and interdental brushes/dental floss were significantly higher in the intervention group than in the control group. Three variables (tooth brushing in workplace, using fluoride toothpaste, and experience of receiving tooth brushing instruction in a dental clinic) showed significant improvement only in the intervention group. On the other hand, work performance and oral status did not significantly change in either group. Our intensive oral health-related behavioral modification intervention improved oral health behavior, but neither work performance nor oral status, among Japanese workers.
The Release of Antimony from Mine Dump Soils in the Presence and Absence of Forest Litter
Authors: Lewińska Karolina , Karczewska Anna , Siepak Marcin , Gałka Bernard
Published: November 2018

This study examined the changes in antimony (Sb) solubility in soils, using organic matter introduced with forest litter, in various moisture conditions. Soils containing 12.8–163 mg/kg Sb were taken from the top layers of dumps in former mining sites in the Sudetes, South-West Poland. Soils were incubated for 90 days either in oxic or waterlogged conditions, with and without the addition of 50 g/kg of beech forest litter (FL). Water concentrations of Sb in some experimental treatments greatly exceeded the threshold values for good quality underground water and drinking water, and reached a maximum of 2.8 mg/L. The changes of Sb solubility caused by application of FL and prolonged waterlogging were, in various soils, highly divergent and in fact unpredictable based on the main soil properties. In some soils, the application of forest litter prompted the release of Sb from soil solid phase, while in the others it acted contradictorily. Soil waterlogging resulted, in most cases, in the increased release of Sb compared to oxic conditions, and this effect was enhanced by the addition of forest litter. However, in two soils the presence of forest litter counteracted the effects of waterlogging and diminished the quantities of released Sb.
Physiological Effects of Viewing Bonsai in Elderly Patients Undergoing Rehabilitation
Authors: Song Chorong , Ikei Harumi , Nara Masahiro , Takayama Daisuke , Miyazaki Yoshifumi
Published: November 2018

The benefits of various nature-derived stimuli that can be used for stress relief and relaxation has recently gained immense attention; however, there are very few studies about their influence on elderly patients. The present study aims to present the effects of viewing bonsai on autonomic nervous activity, prefrontal cortex activity, and subjective assessment findings of psychological relaxation in elderly patients undergoing rehabilitation. Fourteen participants aged 64–91 years (mean age ± standard deviation, 78.6 ± 9.6 years) participated in this study. Miniature potted 10-year-old Japanese cypress bonsai trees were used as visual stimuli. Participants viewed the bonsai for 1 min, and the control comprised of no experimental stimulus. Physiological effects on autonomic nervous activity were assessed by measuring the heart rate variability (HRV) and pulse rate. The effects on prefrontal cortex activity were determined using near-infrared spectroscopy, which involved assessment of oxyhemoglobin concentrations in the left and right prefrontal cortices. Subjective evaluations were achieved by the modified semantic differential method. Viewing bonsai resulted in a significant increase in parasympathetic nervous activity, a significant decrease in sympathetic nervous activity, and a significant increase in the perceptions of feeling “comfortable” and “relaxed.” In conclusion, our findings indicated that viewing bonsai induces physiological and psychological relaxation.
Satisfaction of Physicians Working in Polish Hospitals—A Cross-Sectional Study
Authors: Domagała Alicja , Peña-Sánchez Juan Nicolás , Dubas-Jakóbczyk Katarzyna
Published: November 2018

Physician satisfaction is a multidimensional concept associated with numerous factors. The objectives of the study were to evaluate the satisfaction of physicians practicing in hospitals in Poland and to identify factors associated with higher levels of satisfaction. A quantitative, cross-sectional survey of Polish hospitals was conducted between March and June 2018. All doctors working in the hospitals invited to the study were asked to fill in an online survey. Fifteen hospitals were included: seven general, five specialist, and three university ones. The total number of questionnaires analyzed was 1003. The questionnaire included 17 items to measure the level of satisfaction, classified into four dimensions: personal, professional, performance, and inherent. The statistical analyses included: assessment of association between levels of career satisfaction and basic demographic and work-related variables; and multivariable logistic regressions, conducted to determine which variables were associated with higher levels of career satisfaction. The mean level of career satisfaction, on a scale from 1 to 6, was 4.1 (SD = 0.69). Respondents reported high levels of inherent satisfaction: mean = 4.4 (SD = 0.66) and a low personal satisfaction: mean = 3.78 (SD = 0.98). 56.6% of respondents reported being satisfied, but only 8.2% reported a higher level of satisfaction (≥5). The satisfaction of Polish physicians is moderate. Gender, numbers of working hours/week, years of work experience, type of hospital, and stage of professional development were the identified factors associated with higher levels of career satisfaction.
From a Vegetation Index to a Sustainable Development Goal Indicator: Forest Trend Monitoring Using Three Decades of Earth Observations across Switzerland
Authors: Honeck Erica , Castello Roberto , Chatenoux Bruno , Richard Jean-Philippe , Lehmann Anthony , Giuliani Gregory
Published: November 2018

Forests represent important habitats for species and provide multiple ecosystem services for human well-being. Preserving forests and other terrestrial ecosystems has become crucial to halt desertification, land degradation, and biodiversity loss worldwide, and is also one of the Sustainable Development Goals (SDGs) to be achieved by 2030. Remote sensing could greatly contribute to measuring progress toward SDGs by providing consistent and repetitive coverage of large areas, as well as information in various wavelengths, which facilitates the monitoring of environmental trends at various scales. This paper focuses on SDG indicator 15.1.1—“Forest area as a percentage of total land area” to demonstrate the potential of Earth Observation Data Cubes for SDGs. The approach presented here uses Landsat Analysis Ready Data (ARD) stored in the Swiss Data Cube, and offers a complementary method to ground-based approaches to monitor Switzerland’s forest extent based on the Normalized Difference Vegetation Index (NDVI). The proposed method performs time-series analyses to extract a forest/non-forest map and a graph representing the trend of SDG 15.1.1 indicator over time. Preliminary results suggest that this approach can identify similar forest extent and growth patterns to observed trends, and can therefore help monitor progress toward the selected SDG indicator more effectively.
Characterizing Data Ecosystems to Support Official Statistics with Open Mapping Data for Reporting on Sustainable Development Goals
Authors: Van den Homberg Marc , Susha Iryna
Published: November 2018

Reporting on the Sustainable Development Goals (SDGs) is complex given the wide variety of governmental and NGO actors involved in development projects as well as the increased number of targets and indicators. However, data on the wide variety of indicators must be collected regularly, in a robust manner, comparable across but also within countries and at different administrative and disaggregated levels for adequate decision making to take place. Traditional census and household survey data is not enough. The increase in Small and Big Data streams have the potential to complement official statistics. The purpose of this research is to develop and evaluate a framework to characterize a data ecosystem in a developing country in its totality and to show how this can be used to identify data, outside the official statistics realm, that enriches the reporting on SDG indicators. Our method consisted of a literature study and an interpretative case study (two workshops with 60 and 35 participants and including two questionnaires, over 20 consultations and desk research). We focused on SDG 6.1.1. (Proportion of population using safely managed drinking water services) in rural Malawi. We propose a framework with five dimensions (actors, data supply, data infrastructure, data demand and data ecosystem governance). Results showed that many governmental and NGO actors are involved in water supply projects with different funding sources and little overall governance. There is a large variety of geospatial data sharing platforms and online accessible information management systems with however a low adoption due to limited internet connectivity and low data literacy. Lots of data is still not open. All this results in an immature data ecosystem. The characterization of the data ecosystem using the framework proves useful as it unveils gaps in data at geographical level and in terms of dimensionality (attributes per water point) as well as collaboration gaps. The data supply dimension of the framework allows identification of those datasets that have the right quality and lowest cost of data extraction to enrich official statistics. Overall, our analysis of the Malawian case study illustrated the complexities involved in achieving self-regulation through interaction, feedback and networked relationships. Additional complexities, typical for developing countries, include fragmentation, divide between governmental and non-governmental data activities, complex funding relationships and a data poor context.
Regulating the Regulators: The Control of Transcription Factors in Plant Defense Signaling
Authors: Ng Danny W-K , Abeysinghe Jayami K. , Kamali Maedeh
Published: November 2018

Being sessile, plants rely on intricate signaling pathways to mount an efficient defense against external threats while maintaining the cost balance for growth. Transcription factors (TFs) form a repertoire of master regulators in controlling various processes of plant development and responses against external stimuli. There are about 58 families of TFs in plants and among them, six major TF families (AP2/ERF (APETALA2/ethylene responsive factor), bHLH (basic helix-loop-helix), MYB (myeloblastosis related), NAC (no apical meristem (NAM), Arabidopsis transcription activation factor (ATAF1/2), and cup-shaped cotyledon (CUC2)), WRKY, and bZIP (basic leucine zipper)) are found to be involved in biotic and abiotic stress responses. As master regulators of plant defense, the expression and activities of these TFs are subjected to various transcriptional and post-transcriptional controls, as well as post-translational modifications. Many excellent reviews have discussed the importance of these TFs families in mediating their downstream target signaling pathways in plant defense. In this review, we summarize the molecular regulatory mechanisms determining the expression and activities of these master regulators themselves, providing insights for studying their variation and regulation in crop wild relatives (CWR). With the advance of genome sequencing and the growing collection of re-sequencing data of CWR, now is the time to re-examine and discover CWR for the lost or alternative alleles of TFs. Such approach will facilitate molecular breeding and genetic improvement of domesticated crops, especially in stress tolerance and defense responses, with the aim to address the growing concern of climate change and its impact on agriculture crop production.
Arsenic Trioxide Suppressed Migration and Angiogenesis by Targeting FOXO3a in Gastric Cancer Cells
Authors: Zhang Lin , Liu Lei , Zhan Shining , Chen Lili , Wang Yueyuan , Zhang Yujie , Du Jun , Wu Yongping , Gu Luo
Published: November 2018

Arsenic trioxide (As2O3), a traditional remedy in Chinese medicine, has been used in acute promyelocytic leukemia (APL) research and clinical treatment. Previous studies have shown that As2O3 exerts its potent antitumor effects in solid tumors by regulating cell proliferation and survival. The aim of this study was to investigate whether As2O3 inhibited gastric cancer cell migration and angiogenesis by regulating FOXO3a expression. We found that As2O3 reduced gastric cancer cell viability in a dose-dependent manner and also inhibited cell migration and angiogenesis in vitro. Western blotting and immunofluorescence showed that As2O3 downregulated the levels of p-AKT, upregulated FOXO3a expression in the nucleus, and attenuated downstream Vascular endothelial growth factor (VEGF) and Matrix metallopeptidase 9 (MMP9) expression. Moreover, we demonstrated that knockdown of FOXO3a significantly reversed the inhibition of As2O3 and promoted cell migration and angiogenesis in vitro. Further, As2O3 significantly inhibited xenograft tumor growth and angiogenesis by upregulating FOXO3a expression in vivo. However, knockdown of FOXO3a attenuated the inhibitory effect of As2O3 in xenograft tumors, and increased microvessel density (MVD) and VEGF expression. Our results demonstrated that As2O3 inhibited migration and angiogenesis of gastric cancer cells by enhancing FOXO3a expression.
TSPO Ligands Promote Cholesterol Efflux and Suppress Oxidative Stress and Inflammation in Choroidal Endothelial Cells
Authors: Biswas Lincoln , Farhan Fahad , Reilly James , Bartholomew Chris , Shu Xinhua
Published: November 2018

Choroidal endothelial cells supply oxygen and nutrients to retinal pigment epithelial (RPE) cells and photoreceptors, recycle metabolites, and dispose of metabolic waste through the choroidal blood circulation. Death of the endothelial cells of the choroid may cause abnormal deposits including unesterified and esterified cholesterol beneath RPE cells and within Bruch’s membrane that contribute to the progression of age-related macular degeneration (AMD), the most prevalent cause of blindness in older people. Translocator protein (TSPO) is a cholesterol-binding protein that is involved in mitochondrial cholesterol transport and other cellular functions. We have investigated the role of TSPO in choroidal endothelial cells. Immunocytochemistry showed that TSPO was localized to the mitochondria of choroidal endothelial cells. Choroidal endothelial cells exposed to TSPO ligands (Etifoxine or XBD-173) had significantly increased cholesterol efflux, higher expression of cholesterol homeostasis genes (LXRα, CYP27A1, CYP46A1, ABCA1 and ABCG1), and reduced biosynthesis of cholesterol and phospholipids from [14C]acetate, when compared to untreated controls. Treatment with TSPO ligands also resulted in reduced production of reactive oxygen species (ROS), increased antioxidant capacity, and reduced release of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and VEGF) induced by oxidized LDL. These data suggest TSPO ligands may offer promise for the treatment of AMD.
Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
Authors: Marchetti Bianca
Published: November 2018

Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of the most critical pathways in developing and adult tissues. In the brain, Wnt signaling contributes to different neurodevelopmental aspects ranging from differentiation to axonal extension, synapse formation, neurogenesis, and neuroprotection. Canonical Wnt signaling is mediated mainly by the multifunctional β-catenin protein which is a potent co-activator of transcription factors such as lymphoid enhancer factor (LEF) and T-cell factor (TCF). Accumulating evidence points to dysregulation of Wnt/β-catenin signaling in major neurodegenerative disorders. This review highlights a Wnt/β-catenin/glial connection in Parkinson’s disease (PD), the most common movement disorder characterized by the selective death of midbrain dopaminergic (mDAergic) neuronal cell bodies in the subtantia nigra pars compacta (SNpc) and gliosis. Major findings of the last decade document that Wnt/β-catenin signaling in partnership with glial cells is critically involved in each step and at every level in the regulation of nigrostriatal DAergic neuronal health, protection, and regeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, focusing on Wnt/β-catenin signaling to boost a full neurorestorative program in PD.
In-and-Out Molecular Changes Linked to the Type 2 Diabetes Remission after Bariatric Surgery: An Influence of Gut Microbes on Mitochondria Metabolism
Authors: Samczuk Paulina , Hady Hady Razak , Adamska-Patruno Edyta , Citko Anna , Dadan Jacek , Barbas Coral , Kretowski Adam , Ciborowski Michal
Published: November 2018

Different kinds of gastrointestinal tract modulations known as “bariatric surgery” are actually the most effective treatment for obesity and associated co-morbidities, such as type 2 diabetes (T2DM). The potential causes of those effects have yet to be explained. In our study, we focused on molecular changes evoked by laparoscopic sleeve gastrectomy leading to T2DM remission. Two complementary metabolomics techniques, namely, liquid chromatography coupled with mass spectrometry (LC-MS) and gas chromatography mass spectrometry (GC-MS), were used to study those effects in a group of 20 obese patients with T2DM selected from a cohort of 372 obese individuals who underwent bariatric surgery and did not receive anti-diabetic treatment afterward. Modified levels of carnitines, lipids, amino acids (including BCAA) and α- and β-hydroxybutyric acids were detected. Presented alterations suggest a major role of mitochondria activity in T2DM remission process. Moreover, some of the observed metabolites suggest that changes in gut microbiota composition may also correlate with the tempo of diabetes recovery. Additional analyses confirmed a relationship between biochemical and clinical parameters and the aforementioned metabolites, thereby, highlighting a role of mitochondria and microbes. Our data suggests that there is a previously undescribed relationship between mitochondria and gut microbiota, which changes after the bariatric surgery. More investigations are needed to confirm and explore the observed findings.
A Thioredoxin Domain-Containing Protein Interacts with Pepino mosaic virus Triple Gene Block Protein 1
Authors: Mathioudakis Matthaios M. , Khechmar Souheyla , Owen Carolyn A. , Medina Vicente , Ben Mansour Karima , Tomaszewska Weronika , Spanos Theodore , Sarris Panagiotis F. , Livieratos Ioannis C.
Published: November 2018

Pepino mosaic virus (PepMV) is a mechanically-transmitted tomato pathogen of importance worldwide. Interactions between the PepMV coat protein and triple gene block protein (TGBp1) with the host heat shock cognate protein 70 and catalase 1 (CAT1), respectively, have been previously reported by our lab. In this study, a novel tomato interactor (SlTXND9) was shown to bind the PepMV TGBp1 in yeast-two-hybrid screening, in vitro pull-down and bimolecular fluorescent complementation (BiFC) assays. SlTXND9 possesses part of the conserved thioredoxin (TRX) active site sequence (W__PC vs. WCXPC), and TXND9 orthologues cluster within the TRX phylogenetic superfamily closest to phosducin-like protein-3. In PepMV-infected and healthy Nicotiana benthamiana plants, NbTXND9 mRNA levels were comparable, and expression levels remained stable in both local and systemic leaves for 10 days post inoculation (dpi), as was also the case for catalase 1 (CAT1). To localize the TXND9 in plant cells, a polyclonal antiserum was produced. Purified α-SlTXND9 immunoglobulin (IgG) consistently detected a set of three protein bands in the range of 27–35 kDa, in the 1000 and 30,000 g pellets, and the soluble fraction of extracts of healthy and PepMV-infected N. benthamiana leaves, but not in the cell wall. These bands likely consist of the homologous protein NbTXND9 and its post-translationally modified derivatives. On electron microscopy, immuno-gold labelling of ultrathin sections of PepMV-infected N. benthamiana leaves using α-SlTXND9 IgG revealed particle accumulation close to plasmodesmata, suggesting a role in virus movement. Taken together, this study highlights a novel tomato-PepMV protein interaction and provides data on its localization in planta. Currently, studies focusing on the biological function of this interaction during PepMV infection are in progress.