bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroinflammation triggers microglial phagocytosis of synapses via induction of synaptic filopodia
Authors: Cangalaya Carla , Wegmann Susanne , Sun Weilun , Diez Lisa , Gottfried Anna , Richter Karin , Stoyanov Stoyan , Pakan Janelle , Fischer Klaus-Dieter , Dityatev Alexander
Published: July 2022

Activated microglia play a significant role in synaptic elimination during neuroinflammation, however, the events prior to the uptake of synaptic material by these cells remain elusive. Here, we performed in vivo two-photon imaging of microglia-synapse interactions in the context of systemic inflammation and Alzheimer´s disease. Both treatments induced microglial activation and decreased the basal surveillance of synapses by microglia. Focal synaptic stress was necessary to promote long-lasting microglia-neuron contacts and exacerbate spine elimination. The rate of spine elimination strongly correlated with the frequency of synaptic filopodia generation and microglial expression of phagocytic proteins. We show that activated microglia largely eliminate spines through phagocytosis rather than promoting their rapid retraction into dendrites. Moreover, we found that activated microglia induce the physical stretching of spines and their phagocytosis via the induction of spine head filopodia. Our real-time observations highlight key factors and decision points governing synaptic elimination by microglia during neuroinflammation.
Augmentation of accuracy with the use of different datasets in Artificial Intelligence based corneal ulcer detection
Authors: Daoud Abdullah Akram Raja , Gusseinova Maryamdostu , Celebi Ali Riza Cenk
Published: July 2022

Purpose: The present research was aimed to investigate the Neural Architecture Search (NASNet) based Vertex AI in the Google Cloud platform for detecting corneal ulcers.Methods: In the first model, a total of 712 images of corneal ulcers were obtained from the Kaggle platform and grouped according to the category, type, and grade. After the augmentation of a new set of 352 healthy eye images from another Kaggle dataset, the latest model was tested using Vertex AI.Results: The first model distinguished different categories of corneal ulcers with an accuracy rate of 76.3%, whereas the precision and recall were 80.5% and 57.1%, respectively. The latest model detected corneal ulcers with an accuracy of 98.2%, along with a precision and recall value of 95.1% for both.Conclusion: The performance of Vertex AI can be altered with the use of additional datasets during training for differentiating corneal ulcers among normal eyes.
Anti-cancer potential of substituted ‘amino-alkyl-rhodamine’ derivatives against MCF-7 human breast cancer cell line
Authors: Behera Padma Charan , karmakar Varnita , Ghosh Arya , Dey Suddhasatya , Rangra Naresh Kumar , Bag Bamaprasad
Published: July 2022

Breast cancer is the most prevalent diagnosed cancer among women and the main cause of morbidity and mortality. As for breast cancer, MCF-7 cells are an important candidate since they are widely utilised in research for oestrogen receptor (ER)-positive breast cancer cell assays, and various sub-clones have been identified to reflect different classes of ER-positive tumours with varied levels of nuclear receptor expression. Rhodamines and its derivatives have shown a great interest over the past two decades due to their excellent structural and spectroscopic properties. Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties. Rhodamine derivatives, in particular, have been widely investigated for their therapeutic properties. In this regard, several studies have shown that Rhodamine dye derivatives have promising in vitro and in vivo therapeutic efficacy. The present study deals with potential anticancer activity of few synthesized rhodamine derivatives against MCF-7 cell lines.
Community Reach: Community-Based Screening Program for Hepatitis C Among People Who Use Drugs, Arizona
Authors: Snyder Cassidy , Broman Karen , Meyerson Beth , Choudhury Tripti , Rosa Joby De La , Garcia Roberto C. , Lizarraga Angelica Garcia , Levin Steven , Sieloff Deseree , Sweet Rachael , Weiss Turiya , Wettemann Courteney , Yamaguchi Dusti
Published: July 2022

Background: Efforts to eliminate hepatitis C are hampered by the inability to reach communities with screening opportunities, especially people who use drugs.Purpose: To evaluate the feasibility and impact of a community-based hepatitis C screening program for people who use drugs in Arizona.Methods: This study is a secondary analysis of hepatitis C screening and participant survey data gathered from July 18, 2019 through March 23, 2020. The primary outcome measure was a reactive HCV test. The survey measured demographics in an open-ended manner, presenting an array of response options allowing participants to self-define their identities. The analysis was conducted in 2021.Results: The sample included 541 people from 12 of Arizona’s 15 counties. Over half of the sample (50.8%) reported ever injecting drugs and 21% of the participants were reactive for HCV. Conclusions: Community-based HCV screening among people who use drugs by harm reduction organizations will significantly assist public health efforts to identify people in need of curative HCV treatment early and within supportive environments to address it.
The Cross-talk, Genetic Alteration, Molecular Functions, and Cluster Relevance of the Major Types of Regulated Cell Death in Bladder Cancer
Authors: Zhang Zhihong , Li Jingxian , Qi Yuanjiong , Liu Yang , Liu Xun , Li Shuai , Shi Jianxi , Gao Chao , Li Bo , Zhang Changwen , Du E
Published: July 2022

OBJECTIVE
To determine risk factors of abdominal distention after radical cystectomy and establish a nomogram for clinical risk assessment.
MATERIALS AND METHODS
We collected the clinical information of 139 patients who underwent radical cystectomy from January 2020 to August 2021. The chi-square test, hypergeometric tests, and univariate/multivariate logistic regression were utilized to explore the relationship between variables and abdominal distention after radical cystectomy. Then, a nomogram was used to predict the probability of abdominal distension for the patients who underwent radical cystectomy. Calibration and ROC curves were used to evaluate the accuracy of the model.
RESULTS
We found that 35 patients (25%) occurred in abdominal distention after radical cystectomy. Among these, 7 of them developed intestinal obstruction. Postoperative water fasting time and abdominal surgery history were independent risk factors for abdominal distension after surgery. Finally, we constructed a risk model to predict the probability of abdominal distension after surgery. This model showed good fitting and calibration and excellent diagnostic performance (AUC = 0.804).
CONCLUSION
Postoperative water fasting time and abdominal surgery history were independent risk factors for abdominal distension after surgery. There was no significant difference in the incidence of postoperative abdominal distention between robot-assisted cystectomy and laparoscopic cystectomy.
The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
Authors: Yu Guotai , Matny Oadi , Gourdoupis Spyridon , Johnson Ryan , Aljedaani Fatimah R. , Blilou Ikram , Gardener Catherine H. , Yue Yajuan , Kangara Ngoni , Steuernagel Burkhard , Hayta Sadiye , Smedley Mark , Harwood Wendy , Patpour Mehran , Wu Shuangye , Poland Jesse A. , Jones Jonathan , Reuber Lynne , Ronen Moshe , Sharon Amir , Rouse Matthew , Xu Steven , Holušová Kateřina , Bartos Jan , Molnár István , Karafiátová Miroslava , Jaremko Łukasz , Doležel Jaroslav , Steffenson Brian , Wulff Brande B. H.
Published: July 2022

To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the number of designated resistance genes in the wheat gene pool. Isolating these genes facilitates their fast-tracking in breeding programs and incorporation into polygene stacks for more durable resistance. We cloned the stem rust resistance gene Sr43, which was crossed into bread wheat from the wild grass Thinopyrum elongatum. Sr43 encodes a protein kinase fused to two domains of unknown function. The gene, which is unique to the Triticeae, appears to have arisen through a gene fusion event 6.7 to 11.6 million years ago. Transgenic expression of Sr43 in wheat conferred high levels of resistance to a wide range of isolates of the pathogen causing stem rust, highlighting the potential value of Sr43 in resistance breeding and engineering.
The trend in neuraxial morphine use and postoperative analgesia after cesarean delivery in Japan from 2005 to 2020
Authors: Yonekura Hiroshi , Mazda Yusuke , Noguchi Shohei , Tsunobuchi Hironaka , Shimaoka Motomu
Published: July 2022

The increasing rate of cesarean deliveries warrants obstetric anesthesiologists to deliver high-quality post-cesarean delivery analgesia. The aim of this study was to evaluate the temporal trends in the use of neuraxial morphine for cesarean deliveries and to describe the current postoperative analgesia practices. A retrospective cohort study using nationwide health insurance claims databases was conducted from 2005 to 2020 in Japan. Pregnant women who had undergone cesarean deliveries (elective or emergency) were included. The annual rate of neuraxial morphine use was extracted and analyzed. Additionally, we explored the patient- and facility-level factors associated with neuraxial morphine use through a multilevel logistic regression analysis. The cohort included 65,208 cesarean delivery cases (56,307 patients) from 2,275 institutions. The prevalence of neuraxial morphine use was 16.0% in the overall cohort. Intrathecal morphine was used in 20.6% of spinal anesthesia cases. The trend in neuraxial morphine use steadily increased from 2005 to 2020 (P for trend < 0.001). The significant predictors of neuraxial morphine use included spinal anesthesia, recent surgery, large medical facilities, and academic hospitals. There were variations in the utilization of postoperative analgesia. Our study described the current trend of neuraxial morphine use and the variation in postoperative analgesia practice in Japan.
Formation of a new Russian economy in the context of the economic systems’ transformation
Authors:   East-Siberian State University of Technology and Management, Ulan-Ude, Belomestnov V. , Belomestnov I. ,   FGKU Rosgranstroy, Moscow
Published: July 2022

The article reveals the problems of the impact of the economic systems’ transformation on the Russian economy. It is shown that the modern economy, quite expectedly, but unexpectedly rapidly and with unexpected consequences, has entered the stage of transformation of the world economic system and the construction of a new economic order. The impact of sanctions and embargoes on the economic sectors’ development is revealed. The methods and tools for countering sanctions are considered. The economy interdependence of Russia and foreign non-friendly countries is revealed. The failure of a completely liberal model of market regulation of the economy is shown. Changes in the capital turnover model and the required direction for improving the economic model in accordance with modern conditions are disclosed. The research has been carried out on the dynamics of changes in investment and innovation multipliers in the model of economic growth in Russia, problems and directions of development have been identified. The lessons of modern "recent" economic history for the state management of socio-economic development are considered. The problems of transition to a mobilization "sacrificial" economy for Russia and foreign non-friendly states as a transitional economy for the adaptation period of the economic systems of states to transformation processes and the development of a new economic model of the future based on new development concepts are considered. The foundations of a new economic model have been formed. The relevance of the transition from the existing development model "capital - money - capital" to the model "resources - innovations - resources" understood at a new level is shown. The main ideological concepts of the new economic system are considered - ideology, security, sovereignty, policy in economic, social, technological directions. The current essence of the "new" categories of the consolidated development of society, government and business is revealed - usefulness and efficiency, honesty and justice, creativity and responsibility, interests and activity. The ethical foundations of a new economic model formation of Russia are shown, including the Russian fusion of the "new" national mentality and the factors of the new passionarity of Russia. It is determined that Russia has potential behavioral preferences in the effective implementation of programs and projects for the transformation of economic systems.
INTRAREGIONAL DIFFERENTIATION IN SOCIO-ECONOMIC DEVELOPMENT OF THE TRANSBAIKAL TERRITORY
Authors:   Transbaikal State University, Chita, Gorodkova S. , Imanova A. ,   Transbaikal State University, Chita
Published: July 2022

The uneven spatial and territorial development is characteristic of the economy of any state, regardless of the current economic system, administrative-territorial structure. The regulation of economic processes at the macro level is significantly complicated by the presence of both lagging and rapidly developing entities, because the overall integrity of the national economy is violated due to the uneven distribution of resources. Intra-regional differentiation, as an objective state of uneven socio-economic development of municipalities, which forms a heterogeneous economic space, should be considered in terms of certain social and economic parameters and consequences. To overcome the negative consequences, it is important to assess intra-regional differentiation, which in turn predetermines the problem of choice: the policy of stimulation or equalization. The object of the research is the socio-economic differentiation of municipalities within the region. The subject of research is the factors and methods of regulating intra-regional differentiation. The purpose of the research is to assess the intra-regional socio-economic differentiation of the region in order to determine the main methods and instruments of the regulatory impact of regional authorities. The methodological basis of the research is the traditional methods of economic statistics, as well as the methods of systemic, cause-and-effect analysis, logical methods (analysis and synthesis, induction and deduction). The research characterizes the groups of indicators that characterize the main aspects of the category "socio-economic development", substantiates the methodological aspects of assessing intra-regional differentiation. Based on the materials of the Transbaikal Territory, the region's districts were grouped according to population density, unemployment rate, as priority indicators, which made it possible to outline directions for further research into intra-regional heterogeneity, which characterizes, among other things, the effectiveness of local governments. As a result of the study, municipalities have been identified that have a higher development potential, as well as those that are economically weaker subjects. As priority market instruments for regulating territorial development, the authors consider clusters and measures to transform the sectoral structure of the economy. Thus, sustainable economic growth on the scale of the national economy is ensured by stimulating measures at the regional level, provided primarily by smoothing socio-economic differentiation within the region.
The role of tourism in modern Russian-Mongolian relations
Authors:   Buryat State University named after D. Banzarov, Ulan-Ude, Dorzhieva I. , Tsyrempilova E. ,   Buryat State University named after D. Banzarov, Ulan-Ude
Published: July 2022

The article is devoted to the role of tourism in modern Russian-Mongolian relations. The object of the research is the Russian-Mongolian relations at the present stage of development. The subject of the research is the interaction of Russia and Mongolia in the field of tourism. The goal of the research is to scientifically substantiate the role of tourism in modern Russian-Mongolian relations. In accordance with the goal, the following tasks are defined: 1) to consider the potential of tourism in Russia-Mongolia relations in modern conditions; 2) to highlight the most promising areas of tourism in Russian-Mongolian relations, according to the results of an expert survey. Interdisciplinary approach and the method of comparative analysis are the methodological basis of the research. Tourism is presented as an important resource of the «soft power» of the state, capable of forming a certain image of the state. Along with political and economic cooperation, the tourism potential of the country has a significant impact on the development of relations between countries. As favorable factors contributing to the development of Russian-Mongolian relations in the field of tourism, one can single out the geopolitical position of both countries, a long history of good neighborly cooperation, common history and culture, the availability of tourism resources, and the establishment of a visa-free regime between countries. The COVID-19 coronavirus pandemic and the current unstable situation in world politics had a negative impact on the tourism industry. The importance of expert consideration of some aspects of Russian-Mongolian tourism cooperation is associated with the identification of promising areas and trends in this area and the search for ways to solve existing problems. The potential of tourism as a tool of «soft power» is quite high. Improving the tourism infrastructure, increasing the availability of travel for the population, the availability of effective advertising on the international market, expanding the range of tourism products and services will help strengthen cooperation between Russia and Mongolia not only in the tourism sector, but also in cultural, socio-economic terms
ANALYSIS OF THE TAX BURDEN IN THE QUALITY ASSESSMENT SYSTEM OF THE STATE TAX POLICY
Authors: Goncharova R.
Published: July 2022

By regulating the level of the tax burden by type of economic activity in the tax policy framework, the state can both increase and decrease economic activity, create the necessary market conditions, reduce the shadow economy, create the conditions needed for successful modernization of its priority sectors. The article aims to study the content of the state tax policy in terms of establishing the optimal level of the tax burden, taking into account international experience and the Ukrainian realities of such a policy. The following methods in the work: induction, deduction, analysis, synthesis, and scientific abstraction (to study the content of the concept of "tax policy"); comparison, systematization, and logical generalization. The article analyzes scientific publications on the concept of tax policy and its importance for the economy, based on which he proposed his interpretation, according to which tax policy is the activity of public authorities regulated by law, aimed at providing the necessary tax revenues to centralized funds of the state that are necessary for the adequate performance of tasks and the implementation of the functions entrusted to it, for stable economic growth and improvement of public welfare. Analysis of trends in the tax burden in Ukraine in 2011-2020 showed that the pandemic crisis of 2020-21 and related quarantine restrictions have somewhat reduced the level of tax revenues to the Consolidated Budget compared to pre-crisis periods. However, today there is a general trend towards their growth. According to the study, the share of collected taxes and fees in revenues remained almost unchanged during the entire observation period. It fluctuated within 80%, which indicates that the primary source of filling the State budget is the tax component. The dynamics of the level tax's burden for the analyzed period almost did not change and remained in the range of 34-36%. An analysis of the published results of the Paying Taxes 2020 survey, conducted annually by a World Bank expert group involving the PwC team, showed that Ukraine ranked 65th in the rankings, down 11 points from last year. It establishes that the loss of positions of our state is primarily caus by the advanced actions of other countries to simplify and automate procedures and reduce tax administration time.
The Technological Innovations of Fintech Companies to Ensure the Stability of the Financial System in Pandemic Times
Authors: Baltgailis Jurijs , Simakhova Anastasiia
Published: July 2022

The COVID-2019 pandemic has negatively affected all aspects of the socio-economic development of countries. Both Latvia and Ukraine were not spared from these trends. An important issue for the development of countries at the current stage, especially for Ukraine in the conditions of war, is the development of new technologies that give the possibility to manage the accounts online. The main research purpose is to explore the ability of FinTech companies to provide financial stability during a pandemic. This investigation becomes essential in the view of the other global challenges, such as war. Examination of technological innovation of FinTech development in the paper is carried out in the following logical sequence: studying the development of technological innovations of FinTech companies in Latvia and Ukraine; identifying the positive experience of Lithuania and Estonia in the development of the FinTech sector for Latvia and Ukraine; analyzing the capabilities of FinTech and EcoTech companies. Methodological tools of the research methods were literature analysis (a review of research in FinTech companies) and taxonomic methods used to determine the development and ability of FinTech to ensure financial stability. The research covers 1986-2020. The research object is the FinTech Index and Index of Economic Freedom of Ukraine and Latvia, Estonia, and Lithuania because Ukraine and Latvia lag behind Estonia and Lithuania in terms of their Global FinTech index and, in perspective, could use their positive experience of FinTech development. For this reason, the authors proposed tightening countries` positions according to the criteria of the legislative base, government intervention in the economy, the efficiency of regulation, and openness of the economy. The directions of the development of technological innovation of EcoTech were proposed. The research empirically confirms and theoretically proves the development of FinTech and EcoTech's innovative conception and tools. The research results and recommendations could be useful for transnational corporations to develop the FinTech system.
Influence of new humic preparation on remediation of oil-contaminated soil
Authors: Fomicheva N. V. , Smirnova Yu. D. , Rabinovich G. Yu.
Published: July 2022

A humic preparation obtained through alkaline extraction of humic-containing raw materials at the All-Russian Research Institute of Reclaimed Lands (branch of the V. V. Dokuchaev Soil Science Institute) is presented. The aim of the work is to study the effect of the humic preparation – named BoGum – on the remediation of oil-contaminated podzols. In a model experiment for soil remediation, artificially contaminated with oil in an amount of 5%, BoGum was used in 3 doses: as a stimulant of aboriginal microflora (300 l/ha), as a fertiliser (3000 l/ha), and as a sorbent (30000 l/ha). BoGum was found to be more effective as a stimulator of aboriginal microflora, whose maximum was observed one month following application, while the degree of destruction of oil over the two months of the experiment was 40.1%. Over the course of the experiment, it was determined that humic substances of the preparation were a more affordable source of nutrition for the soil microflora when BoGum was used as a sorbent; the breakdown of oil was the lowest when petroleum hydrocarbons were inaccessible to microorganisms due to sorption. The maximum degree of breakdown (44.9%) occurred with the combined use of the microbial preparation MicroBak (development of the Institute of Biochemistry and Physiology of Microorganisms of the Russian Academy of Sciences) and the humic preparation BoGum at a dosage of 300 l/ha. The preparation demonstrated a synergistic effect, which affected the active development of both hydrocarbon-oxidising microorganisms and aboriginal microflora. The percentage of the hydrocarbon-oxidising microorganisms from the total number of heterotrophs in all experimental variants was maximum in two weeks; this was reduced at different intensities. Calculated multiple regression equations were used to estimate the physiological influence of the groups of microorganisms on the degree of degradation being investigated.
Antioxidant indices of red currant cultivars grown in the Sverdlovsk Oblast
Authors: Chugunova O. V. , Vyatkin A. V. , Tiunov V. M. , Chebotok E. M.
Published: July 2022

In this work, nine varieties of red currant cultivars, recognized for use in the Sverdlovsk Oblast, were studied. According to the conducted analysis, the Epsilon cultivar demonstrated the highest antioxidant indicators (mmol/dm3eq) of 13.772 ±0.275. For comparison, the Ilyinka and Luchezarnaya cultivars showed the values of 12.826 ±0.257 and 11.933±0.239, respectively. The late ripening cultivar Zeta showed the lowest antioxidant value of 6.428±0.129 mmol/dm3eq. At the same time, the highest content of flavonoids was characteristic of such red currant cultivars (mg/100 g of edible part, variety) as Epsilon – 50.3±0.9, Beta – 44.2±0.9, Ogni Urala – 45.7±0.9 and Zeta – 17.3±0.3, while the Lychezarnaya cultivar showed the lowest value of 16.1±0.3. In terms of anthocyanins, the highest values (mg of cyanidin-3-glycoside/100 g of edible part) were observed in the Kapitalina, Ilyinka and Lychezarnaya cultivars, equalling 29.1±0.6, 38.1±0.7 and 41.2±0.8, respectively. The average ripening cultivar Alaya Zorka showed the lowest anthocyanin value of 11.9±0.2. The Kapitalina, Ilyinka and Luchezarnaya cultivars demonstrated the highest amounts of phenolic substances (mg of gallic acid/100 g of edible part) of 212.9±4.3, 235.1±4.7 and 168.3±3.3, respectively. In terms of this indicator, the Beta cultivar showed the lowest value of 114.1±2.3. The consumer characteristics of the cultivars were studied, including their acidity, as well as the content of total and reducing sugars. The obtained results can be used when selecting dietary supplements based on red currant berries and determining the nutritional value of diets in order to increase their overall antioxidant activity.
THE EFFECT OF SYNBIOTIC ON CARCASS PERCENTAGE AND ABDOMINAL FAT PERCENTAGE OF NATIVE CHICKEN
Authors:   Faculty of Science and Technology, University of Pembangunan Panca Budi, Medan, Indonesia., Setyaningrum Sri , Julia Sari Siregar Dini ,   Faculty of Science and Technology, University of Pembangunan Panca Budi, Medan, Indonesia., Riah Ate Tarigan Ruth ,   Faculty of Science and Technology, University of Pembangunan Panca Budi, Medan, Indonesia., a Warisman ,   Faculty of Science and Technology, University of Pembangunan Panca Budi, Medan, Indonesia.
Published: July 2022

The aim of this study was to evaluate the effect of synbiotic on carcass percentage and abdominal fat percentage of native chicken. This research used 120 birds of native chicken. Basal diet in this research formulated with metabolizable energy (ME) 3000 kcal/kg and crude protein 19%. Completely randomized design used in this research with 6 treatment and 4 replicates. The 6 treatments were P0: control (without synbiotic), P1: basal diet + 1.0% of synbiotic, P2: basal diet + 1.5% of synbiotic, P3: basal diet + 2.0% of synbiotic, P4:basal diet + 2.5% of synbioticand P5: basal diet + 3.0% of synbiotic. The parameters in this research were live weight, carcass percentage and abdominal fat percentage. Based on this research showed that the treatment of synbiotic significant different (p<0.05) on live weight, carcass percentage and abdominal fat percentage of native chicken. Conclusion of the research was the supplementation of synbiotic increased of liveweight and carcass percentageand reduced of abdominal fat percentage of native chicken.
REPRESENTACIONES IMPLÍCITAS DE INNOVACIÓN CURRICULAR DE PROFESORES DE EDUCACIÓN SUPERIOR
Authors: Ramos Ramírez Briseda Noemí , Barrón Tirado María Concepción
Published: July 2022

El artículo presenta los resultados de una investigación acerca de las representaciones implícitas del profesorado de educación superior sobre la innovación curricular y su relación con el desempeño en el aula. El estudio se llevó a cabo con docentes de una licenciatura de la Universidad de Colima, en la que se implementó el modelo basado en competencias como parte de un proceso de innovación curricular. Participaron catorce docentes. La investigación se realizó bajo un enfoque cualitativo-descriptivo y se utilizó un cuestionario elaborado con base en dilemas y preguntas abiertas, como instrumento para la recogida de información. Se puede afirmar que el análisis de las representaciones implícitas de los docentes comienza en la autopercepción en torno a su desempeño; sus creencias, bagaje cultural y su contexto social, son determinantes en su concepción en relación con el aprendizaje, la enseñanza, la evaluación y la innovación. En términos generales, se identifica el compromiso con la enseñanza, el interés por los estudiantes y la contradicción entre un pensamiento lineal o progresivo y una práctica que añade herramientas didácticas que presumen de resultados metacognitivos: todo esto inmerso en un contexto de construcción y reconstrucción de la enseñanza de manera continua.
Evolution of the Regional Electoral Process in the Kemerovo Region
Authors: Kislyakov Mikhail , Vostrikov Konstantin
Published: July 2022

The present research featured regional elections and electoral processes. The objective was to analyze the changes in research approaches, forms, and content of elections. The historical-comparative, systemic, and secondary analysis made it possible to identify the strengths, weaknesses, opportunities, and threats for election campaigns to the State Duma in the Kemerovo region in 1993–2021. The article focuses on the concept, structure, stages, essence, efficiency, and trends of the electoral process in Russia and in the region.
Rumours and Fake News – Effects of Message Credibility on Human Behaviour during the Corona Pandemic
Authors: Kempkens Oliver Harald
Published: July 2022

Recessionary situations such as the current Corona pandemic affect people’s behaviour, since most people react to them with fear. Nowadays, social media is used by many people all over the world, thus, people as well as public and private organizations and groups share, post and comment messages on social media. This way, many people can be reached in a very short time. However, not all posts on social media can be defined trustworthy. Instead, a lot of people, groups and organizations make use of social media to spread rumours, fake news and conspiracy theories. There are three main motivations increasing people’s beliefs in these types of news: desire to feel security for themselves as well as the groups they belong to; making sense of their specific environment and /or striving for safety and control in times of severe recessionary situations. Among the current demonstrators against the Corona policy of the German government, one can often identify supporters of specific groups that share their beliefs. However, it is not easy to differentiate between true and fake news or rumours. The present paper uses the quantitative data collection method to investigate the reasons why people may change their behaviour in recessionary situations and why some people are more prone to believing rumours and fake news on social media than others. In this context, message credibility plays an important role. The results show that rumours, fake news and conspiracy theories are able to decrease people’s trust in health agencies and / or governments.
Segmentation of Regional Tourist Flows
Authors: Pustovoytenko Svetlana
Published: July 2022

The article introduces theoretical foundations for regional tourist flows segmentation. It is a management tool that distributes, attracts, and restrains tourist traffic. The research objective was to develop some methodological recommendations for segmentation of regional tourist flows based on goals and attributes. The study involved domestic and foreign research publications, materials of the World Tourism Organization, specialized dictionaries and encyclopedias, methods for calculating inbound and outbound tourist flows, legal documents on segmentation, etc. The list of research methods included comparison, analysis, synthesis, system and complex approach, tabular method, graphic modeling, etc. The obtained results were represented as algorithms for analysis and segmentation of regional tourist flows, which can be used in the theory and practice of tourism, in federal, regional, and local tourism management, in tourism education, etc. The authors believe that segmentation of regional tourist traffic produces targeted tourist products, replenishes local budgets, ensures sustainable development of recreational areas, and prevents negative consequences of tourism development.
Labor Productivity of Miners at Open Pits and Mines of the Kemerovo Region
Authors: Batievskaya V , Sokolovskiy Mihail
Published: July 2022

he dynamic socio-economic development of Russia depends on the growth of labor force and productivity. This article introduces an analysis of labor productivity in coal-mining regions and the experience of Kuzbass mining. The authors explored the twelve-year dynamics of the labor productivity index both for the Russian economy as a whole and for its coal-mining regions. They identified the main trends in the management of labor productivity at the coal enterprises of the Kemerovo Region. The statistical analysis showed that the labor productivity index in Russia is slightly declining, especially in the mining industry. This negative trend can be avoided by applying new methods of personnel management, developing social and labor relations, involving employees in the labor process and encouraging their labor awareness, digitalizing all technological processes, and developing an effective contract.
Genetic Variant of Vascular Endothelial Growth Factor (VEGF)-A rs699947 is Associated with Preeclampsia
Authors: Puspasari Anggelia , Enis Rina Nofri , Herlambang Herlambang
Published: July 2022

Background: Preeclampsia remains as the leading cause of maternal-neonatal mortality and morbidity worldwide. Vascular endothelial growth factor A (VEGF-A) is a proangiogenic factor related to endothelial dysfunction and plays an important role in the preeclampsia pathophysiology. Genetic variants of VEGF-A are associated with VEGF-A expression and preeclampsia risk, however there are still inconsistent results between different populations. The aim of this study was to determine the association of this genetic variant as preeclampsia risk factor.Materials and methods: A cross-sectional study was performed with 76 pregnant women (29 preeclampsia and 47 normotensive) Jambi-Malay ethnic subjects. Sample DNA was extracted from subject’s blood. To determine the genotype, one-step tetra amplification refractory mutation system (ARMS) polymerase chain reaction (PCR) method for VEGF-A rs699947 C/A was used.Results: We found that pregnant woman with AC genotype (p-value=0.045; OR=2.76 ; 95% CI=1.01-7.58) and AA genotype (p-value=0.026; OR=12.44; 95% CI=1.23-126.18) had higher risk of preeclampsia than the CC genotype.Conclusion: Genetic variant VEGF-A rs699947 C/A is associated with preeclampsia. The AC and AA genotype is the risk genotype for preeclampsia in Jambi-Malay ethnics.Keywords: preeclampsia, VEGF-A, genetic variant, Jambi-Malay, Indonesia
(Re)conhecendo a dimensão da gestão em saúde em um currículo médico
Authors: Ribeiro Rodrigues Luciane Cristine , Casquel Monti Juliani Carmen Maria , Ribeiro Mattar Damiance Patrícia , Garbellotti Thayná Maria
Published: July 2022

No Brasil, há significativa representatividade do médico em cargos institucionais administrativos, no entanto, alguns atuam sem os conhecimentos gerais e específicos das bases da administração pública e da gestão em saúde. Com base nesse pressuposto, objetivou-se apresentar uma caracterização geográfica, administrativa e pedagógica dos cursos de medicina do Brasil e, em particular, do estado de São Paulo, identificando como a temática gestão em saúde é trabalhada nesses cursos, bem como compreender a experiência de docentes da saúde relativamente à expressão da gestão em saúde, em um currículo médico. Trata-se de uma pesquisa quanti-qualitativa. Este artigo apresenta os resultados de duas das fases quantitativas e de parte da fase qualitativa da qual participaram 38 docentes de uma instituição pertencente à rede de ensino superior municipal. Observou-se a prevalência da entidade administrativa privada e do regime letivo semestral, nos cursos analisados. Não foi possível afirmar categoricamente que temáticas relacionadas com a gestão em saúde sejam efetivamente abordadas, nas graduações em medicina do estado de São Paulo. Todavia, os docentes participantes deste estudo reconhecem o valor dos conteúdos conceituais, procedimentais e atitudinais da gestão em saúde na formação inicial do médico. Conclui-se que é preciso equacionar as relações entre as Diretrizes Curriculares Nacionais para a graduação em medicina do Brasil e a prática pedagógica, a intencionalidade administrativa e as perspectivas de formação dos gestores da educação médica, indicando os passos a serem seguidos para a concepção e a execução de currículos estruturados, no eixo da gestão em saúde.
Perspetivas múltiplas sobre a competência bilingue de crianças lusodescendentes residentes na Suíça
Authors: Flores Cristina , Gonçalves Maria Lurdes , Rinke Esther , Torregrossa Jacopo
Published: July 2022

O presente artigo apresenta os resultados de um estudo empírico sobre a competência bilingue de 180 crianças lusodescendentes, residentes em três áreas linguísticas da Suíça (alemã, francesa e italiana). Com recurso a um cloze test e a um questionário parental detalhado, os resultados mostram que o desenvolvimento do português, a língua de herança (LH) dos participantes, é moldado pela quantidade e o tipo de contacto com a LH no seio da família. Mostra-se, também, que a proficiência em ambas as línguas está positivamente correlacionada, desconstruindo a conceção subtrativa do bilinguismo migratório. Complementarmente, foram recolhidas as opiniões dos professores do Ensino Português no Estrangeiro (EPE) Suíça, do Camões - Instituto da Cooperação e da Língua, através de um questionário e de uma oficina de formação, realçando a necessidade de diálogo triangular entre a investigação científica sobre aquisição da linguagem, a prática didática e a gestão linguística no seio de famílias portuguesas na diáspora.
Tolok Ukur Penilaian Ekspresi Gambar Anak Usia Dini Usia 4-6 Tahun
Authors: Prayitno Prayitno
Published: July 2022

Karya gambar merupakan salah satu media komunikasi rupa anak-anak, komunikasi tersebut divisualisasikan oleh ekspresi gambar. Setiap anak terutama anak usia dini memiliki ekspresi gambar berbeda-beda, ada yang baik, cukup baik, bahkan ada yang kurang baik. Tujuan penulisan artikel penelitian  ini adalah untuk mendeskripsikan atau menggambarkan bagiamana tolok ukur penilaian ekspresi gambar anak usia dini usia 4-6 tahun, dari tiga tempat lembaga pendidikan (tempat kursus atau sanggar) di Kota Bandung. Penelitian ini menggunakan metode deskriptif analisis. Teknik pengumpulan data pada penelitian ini yaitu dengan observasi, wawancara, dan dokumentasi, setelah itu dianalisis dengan instrumen penilaian gambar anak. Fokus kajian penelitian ini meliputi karya gambar, bentuk objek gambar dan warna dari hasil karya gambar anak usia dini usia 4-6 tahun. Dari hasil analisis penulis bahwa ekpresi gambar yang baik terdapat sekitar tiga perempat dan ekspresi gambar dengan kategori cukup baik terdapat sekitar seperempatnya dari jumlah keseluruhan. Aspek dalam menilai karya gambar anak usia dini ini dibuat sederhana,  sehingga mudah dipahami oleh guru-guru TK (Taman Kanak-Kanak). Hasil penelitian ekspresi gambar anak usia dini ini dapat dijadikan referensi serta dapat membantu guru TK (Taman Kanak-Kanak) dalam mengapresiasi karya gambar anak didiknya.
Pelaksanaan Pembelajaran Seni Rupa di Masa Pandemi Covid-19: Studi Kasus TK/RA Ma’Arif Candran
Authors: Wulandari Dwi , Naibaho Ledistar Sumin , Putri Lia Amanda , Kirana Beata Melati Senja , Ardhianto Dimas Ganang , Haidar Ahmad
Published: July 2022

Seni rupa merupakan bahasa pertama anak dan salah satu sarana yang menghubungkan anak dengan lingkungan di sekitarnya.  Pembelajaran seni rupa untuk anak-anak menjadi aspek penting bagi dunia pendidikan. Sayangnya, kondisi pandemi Covid-19 yang mengharuskan pembatasan sosial ketat telah membawa tantangan tersendiri bagi pelaksanaan pendidikan khususnya pembelajaran seni rupa. Penelitian ini berusaha menganalisis secara etnografis pelaksanaan pembelajaran seni rupa selama pandemi Covid-19 dengan menitik-beratkan aspek sosio-kultural subjek penelitian yaitu TK/RA Ma’arif Candran. Data dikumpulkan melalui dokumentasi, wawancara, dan observasi. Melalui model analisis data interaktif, disimpulkan bahwa RA Ma’Arif Candran tetap melaksanakan pembelajaran secara luring termasuk pembelajaran seni rupa selama masa pandemi Covid-19 menyesuaikan dengan kondisi dan aturan yang ditetapkan pemerintah. Seluruh aktivitas pembelajaran dilakukan dengan protokol kesehatan ketat. Pelaksanaan pembelajaran seni rupa di masa pandemi Covid-19 tidak sebebas pelaksanaan pada kondisi normal. Interaksi guru dan anak tidak seideal yang diharapkan. Meskipun pembelajaran berjalan dengan relatif kondusif, hasil pembelajaran seni rupa yang dilaksanakan juga dirasa oleh guru tidak bisa optimal. Inovasi- invovasi pembelajaran yang dapat meningkatkan kualitas pembelajaran seni rupa dalam situasi yang mengharuskan pembatasan sosial masih sangat diperlukan.
Peran Lingkungan Sekolah dalam Pembentukan Karakter Anak Usia Dini di PAUD Nurul Ikhlas
Authors: Irhamna Irhamna , Purnama Sigit
Published: July 2022

Pendidikan karakter sangat penting bagi anak karena membentuk anak menjadi pribadi yang lebih baik. Pembentukan karakter anak dipengaruhi oleh faktor  keluarga, masyarakat, dan sekolah. Sekolah merupakan salah satu tempat pembentukan karakter bagi anak. Hal ini disebabkan anak banyak menghabiskan waktunya bersama guru, teman sebaya, maupun orang dewasa lainnya yang ada di sekolah. Penelitian ini bertujuan untuk mendeskripsikan peran lingkungan sekolah dalam membentuk karakter pada anak di PAUD Nurul Ikhlas. Penelitian ini menggunakan metode penelitiani deskriptif kualitatif. Teknik pengumpulan datanya menggunakan teknik wawancara dan observasi. Analisis data mengunakan model Miles dan Huberman. Model ini menggunakan pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa pembentukan karakter pada anak usia dini di PAUD Nurul Ikhlas dengan cara menegakkan kedisiplinan pada anak, guru terlibat penuh dalam membangun karakter, menjadi contoh yang baik atau teladan bagi anak, menumbuhkan nilai-nilai keutamaan pada diri anak, dan membentuk stategi pembelajaran yang aktif dan menarik.
Pelaksanaan Pembelajaran Proyek secara Daring (Dalam Jaringan) di Lab School CITTA
Authors: Maryatun Ika Budi , Firdhaus Nurul Amalia
Published: July 2022

Pembelajaran proyek mulai diterapkan oleh guru karena menjadi pendekatan pembelajaran yang mampu melibatkan anak secara aktif dalam menginvestigasi topik secara mendalam dan konkret. Artikel ini bertujuan untuk menjabarkan pelaksanaan pembelajaran proyek secara daring di Lab School Sekolah CITTA. Penelitian menggunakan pendekatan kualitatif dengan sumber data guru dan anak di sekolah. Data dikumpulkan menggunakan teknik wawancara, observasi, dan dokumentasi yang kemudian dianalisis menggunakan dua langkah analisis dari lima yang ada model Spradley, yaitu analisis domain dan tema. Keabsahan data dilakukan dengan triangulasi dan perpanjangan keikutsertaan. Hasil penelitian mendapati bahwa pelaksanaan pembelajaran proyek secara daring dilakukan tetap menggunakan tiga langkah, yaitu persiapan terdiri dari pemilihan tema dan mencari informasi, pelaksanaan terdiri dari pembuka/penyapa, kegiatan inti, dan teknik/tampilan, serta evaluasi yang berisi pendokumentasian video dan foto kegiatan anak. Perbedaan dengan pelaksanaan pembelajaran proyek secara luring ada pada penyampaian. Jika luring dilakukan di sekolah dan dibimbing langsung oleh guru, maka pelaksanaan proyek secara daring dilaksanakan menggunakan aplikasi whatsapp¸ voice note, zoom, maupun video sesuai kondisi. Proyek diselesaikan anak di rumah dengan dampingan orangtua. Guru menerima kiriman video, voice note, atau foto kegiatan anak dari orang tua untuk diolah menjadi penilaian. Artikel hasil penelitian ini diharapkan dapat memberikan gambaran pelaksanaan pembelajaran proyek dalam kondisi darurat sekalipun.
Criteria for Sustainable Landscape Maintenance: Addressing Cost Implication
Authors: Ayob Zulkefle , Ahmad Suriati , Shinbira Ibrahim Abdallah
Published: July 2022

The upkeeping of urban public parks involves tedious maintenance to sure their functionality, purpose and it involves an immense amount to maintain our public parks. This mixed-methodology research examines the cost-efficiency and strategies to mitigate this issue. The first phase established an experts’ verified checklist of maintenance procedures establishing the themes, parameters, and attributes for cost-effective maintenance. Phase two involves Semi-structured Interviews with selected professionals and practitioners focusing on issues related to the current landscape maintenance practice and its operational cost. The study’s findings suggest six components that link effective maintenance with cost-efficiency.
Keywords: Urban Parks, Maintenance Procedure, Cost-effective, Sustainable Maintenance Process
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
Managing Family and Work: The Search for the Ideal Work-life Balance
Authors: Saad Mazni , Jaafar Aishah Nawwarah , Azman Ong Mohd Hanafi , Eni Yulinda  , Muthu Kumarasamy Mokana
Published: July 2022

Employers in the food and beverage (F&B) industry require many high-skilled and well-trained professionals but workers are often exploited in the industry. Aiming to answer if personal health, personal time management, and family matters affect the work-life balance (WLB) of F&B employees, which family matters played a mediator role. The data of 108 responses was analysed through the PROCESS analysis and Sobel's Test. The regression analysis shows that family matters are a mediator of the relationship between personal health and personal time management and WLB indicating that the variable is vital in ensuring a healthy WLB among F&B’s employees.  
Keywords: Family matters; Personal health; Personal time management; Quality of life
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3477