bluuebunny/crossref_metadata_2025 huggingface dataset:
Secretome of Stressed Peripheral Blood Mononuclear Cells Alters Transcriptome Signature in Heart, Liver, and Spleen after an Experimental Acute Myocardial Infarction: An In Silico Analysis
Authors: Mildner Caterina Selina , Copic Dragan , Zimmermann Matthias , Lichtenauer Michael , Direder Martin , Klas Katharina , Bormann Daniel , Gugerell Alfred , Moser Bernhard , Hoetzenecker Konrad , Beer Lucian , Gyöngyösi Mariann , Ankersmit Hendrik Jan , Laggner Maria
Published: January 2022

Acute myocardial infarction (AMI) is a result of cardiac non-perfusion and leads to cardiomyocyte necrosis, inflammation, and compromised cardiac performance. Here, we showed that the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) improved heart function in a porcine AMI model and displayed beneficial long- and short-term effects. As an AMI is known to strongly affect gene regulation of the ischemia non-affected heart muscle and distal organs, we employed a transcriptomics approach to further study the immediate molecular events orchestrated using the PBMCsec in myocardium, liver, and spleen 24 h post ischemia. In the infarcted area, the PBMCsec mainly induced genes that were essential for cardiomyocyte function and simultaneously downregulated pro-inflammatory genes. Interestingly, genes associated with pro-inflammatory processes were activated in the transition zone, while being downregulated in the remote zone. In the liver, we observed a pronounced inhibition of immune responses using the PBMCsec, while genes involved in urea and tricarboxylic cycles were induced. The spleen displayed elevated lipid metabolism and reduced immunological processes. Together, our study suggested several types of pharmacodynamics by which the PBMCsec conferred immediate cardioprotection. Furthermore, our data supported the assumption that an AMI significantly affects distal organs, suggesting that a holistic treatment of an AMI, as achieved by PBMCsec, might be highly beneficial.
A Bibliometric Analysis of Mexican Bioinformatics: A Portrait of Actors, Structure, and Dynamics
Authors: Armenta-Medina Dagoberto , Díaz de León Castañeda Christian , Armenta-Medina Alma , Perez-Rueda Ernesto
Published: January 2022

Bioinformatics is a very important informatics tool for health and biological sciences, focusing on biological data management. The objective of this work was to perform a bibliometric analysis regarding the development of Mexican bioinformatics. An exhaustive revision of the literature associated with Mexican bioinformatics in a period of 25-years was performed. Bibliometric tools, such as performance analysis and science mapping were included in the analysis. We identified the main actors as well as the structure and dynamics of Mexican bioinformatics. Some of the main findings were as follows: the thematic structure in the field is defined by the research lines of outstanding authors; the outstanding collaborations of Mexican institutions with foreign countries and institutions are influenced by the geographic proximity and binational agreements, as well as philanthropic and academic programs that promote collaborations, and there is an inclination for health issues promoted by public health financing and philanthropic organizations. It is identified that publications had an explosion since 2012, we consider that this growth may be influenced by the democratization of data, derived from the mass sequencing of biological molecules stored in public databases.
SPR Analysis of SUMO-Murine Rap1-Interacting Factor 1 C-Terminal Domain Interaction with G4
Authors: Alavi Sana , Ghadiri Hamed , Dabirmanesh Bahareh , Khajeh Khosro
Published: January 2022

One of the advantages of surface plasmon resonance is its sensitivity and real-time analyses performed by this method. These characteristics allow us to further investigate the interactions of challenging proteins like Rap1-interacting factor 1 (Rif1). Rif1 is a crucial protein responsible for regulating different cellular processes including DNA replication, repair, and transcription. Mammalian Rif1 is yet to be fully characterized, partly because it is predicted to be intrinsically disordered for a large portion of its polypeptide. This protein has recently been the target of research as a potential biomarker in many cancers. Therefore, finding its most potent interacting partner is of utmost importance. Previous studies showed Rif1’s affinity towards structured DNAs and amongst them, T6G24 was superior. Recent studies have shown mouse Rif1 (muRif1) C-terminal domain’s (CTD) role in binding to G-quadruplexes (G4). There were many concerns in investigating the Rif1 and G4 interaction, which can be minimized using SPR. Therefore, for the first time, we have assessed its binding with G4 at nano-molar concentrations with SPR which seems to be crucial for its binding analyses. Our results indicate that muRif1-CTD has a high affinity for this G4 sequence as it shows a very low KD (6 ± 1 nM).
An Approach to Air-to-Surface Mission Planner on 3D Environments for an Unmanned Combat Aerial Vehicle
Authors: Woo Ji-Won , Choi Yoo-Seung , An Jun-Young , Kim Chang-Joo
Published: January 2022

Recently, interest in mission autonomy related to Unmanned Combat Aerial Vehicles(UCAVs) for performing highly dangerous Air-to-Surface Missions(ASMs) has been increasing. Regarding autonomous mission planners, studies currently being conducted in this field have been mainly focused on creating a path from a macroscopic 2D environment to a dense target area or proposing a route for intercepting a target. For further improvement, this paper treats a mission planning algorithm on an ASM which can plan the path to the target dense area in consideration of threats spread in a 3D terrain environment while planning the shortest path to intercept multiple targets. To do so, ASMs are considered three sequential mission elements: ingress, intercept, and egress. The ingress and egress elements require a terrain flight path to penetrate deep into the enemy territory. Thus, the proposed terrain flight path planner generates a nap-of-the-earth path to avoid detection by enemy radar while avoiding enemy air defense threats. In the intercept element, the shortest intercept path planner based on the Dubins path concept combined with nonlinear programming is developed to minimize exposure time for survivability. Finally, the integrated ASM planner is applied to several mission scenarios and validated by simulations using a rotorcraft model.
A Multifractal Analysis and Machine Learning Based Intrusion Detection System with an Application in a UAS/RADAR System
Authors: Zhang Ruohao , Condomines Jean-Philippe , Lochin Emmanuel
Published: January 2022

The rapid development of Internet of Things (IoT) technology, together with mobile network technology, has created a never-before-seen world of interconnection, evoking research on how to make it vaster, faster, and safer. To support the ongoing fight against the malicious misuse of networks, in this paper we propose a novel algorithm called AMDES (unmanned aerial system multifractal analysis intrusion detection system) for spoofing attack detection. This novel algorithm is based on both wavelet leader multifractal analysis (WLM) and machine learning (ML) principles. In earlier research on unmanned aerial systems (UAS), intrusion detection systems (IDS) based on multifractal (MF) spectral analysis have been used to provide accurate MF spectrum estimations of network traffic. Such an estimation is then used to detect and characterize flooding anomalies that can be observed in an unmanned aerial vehicle (UAV) network. However, the previous contributions have lacked the consideration of other types of network intrusions commonly observed in UAS networks, such as the man in the middle attack (MITM). In this work, this promising methodology has been accommodated to detect a spoofing attack within a UAS. This methodology highlights a robust approach in terms of false positive performance in detecting intrusions in a UAS location reporting system.
MFAN: Multi-Level Features Attention Network for Fake Certificate Image Detection
Authors: Sun Yu , Ni Rongrong , Zhao Yao
Published: January 2022

Up to now, most of the forensics methods have attached more attention to natural content images. To expand the application of image forensics technology, forgery detection for certificate images that can directly represent people’s rights and interests is investigated in this paper. Variable tampered region scales and diverse manipulation types are two typical characteristics in fake certificate images. To tackle this task, a novel method called Multi-level Feature Attention Network (MFAN) is proposed. MFAN is built following the encoder–decoder network structure. In order to extract features with rich scale information in the encoder, on the one hand, we employ Atrous Spatial Pyramid Pooling (ASPP) on the final layer of a pre-trained residual network to capture the contextual information at different scales; on the other hand, low-level features are concatenated to ensure the sensibility to small targets. Furthermore, the resulting multi-level features are recalibrated on channels for irrelevant information suppression and enhancing the tampered regions, guiding the MFAN to adapt to diverse manipulation traces. In the decoder module, the attentive feature maps are convoluted and unsampled to effectively generate the prediction mask. Experimental results indicate that the proposed method outperforms some state-of-the-art forensics methods.
A Damping-Tunable Snap System: From Dissipative Hyperchaos to Conservative Chaos
Authors: Ketthong Patinya , Srisuchinwong Banlue
Published: January 2022

A hyperjerk system described by a single fourth-order ordinary differential equation of the form x⃜=f(x⃛,x¨,x˙,x) has been referred to as a snap system. A damping-tunable snap system, capable of an adjustable attractor dimension (DL) ranging from dissipative hyperchaos (DL<4) to conservative chaos (DL=4), is presented for the first time, in particular not only in a snap system, but also in a four-dimensional (4D) system. Such an attractor dimension is adjustable by nonlinear damping of a relatively simple quadratic function of the form Ax2, easily tunable by a single parameter A. The proposed snap system is practically implemented and verified by the reconfigurable circuits of field programmable analog arrays (FPAAs).
Estimation of Seismic Wave Attenuation from 3D Seismic Data: A Case Study of OBC Data Acquired in an Offshore Oilfield
Authors: Bouchaala Fateh , Ali Mohammed Y. , Matsushima Jun , Bouzidi Youcef , Jouini Mohammed S. , Takougang Eric M. , Mohamed Aala A.
Published: January 2022

Previous studies performed in Abu Dhabi oilfields, United Arab Emirates, revealed the direct link of seismic wave attenuation to petrophysical properties of rocks. However, all those studies were based on zero offset VSP data, which limits the attenuation estimation at one location only. This is due to the difficulty of estimating attenuation from 3D seismic data, especially in carbonate rocks. To overcome this difficulty, we developed a workflow based on the centroid frequency shift method and Gabor transform which is optimized by using VSP data. The workflow was applied on 3D Ocean Bottom Cable seismic data. Distinct attenuation anomalies were observed in highly heterogeneous and saturated zones, such as the reservoirs and aquifers. Scattering shows significant contribution in attenuation anomalies, which is unusual in sandstones. This is due to the complex texture and heterogeneous nature of carbonate rocks. Furthermore, attenuation mechanisms such as frictional relative movement between fluids and solid grains, are most likely other important causes of attenuation anomalies. The slight lateral variation of attenuation reflects the lateral homogeneous stratigraphy of the oilfield. The results demonstrate the potential of seismic wave attenuation for delineating heterogeneous zones with high fluid content, which can substantially help for enhancing oil recovery.
Design and Costs Analysis of Hydrogen Refuelling Stations Based on Different Hydrogen Sources and Plant Configurations
Authors: Perna Alessandra , Minutillo Mariagiovanna , Di Micco Simona , Jannelli Elio
Published: January 2022

In this study, the authors present a techno-economic assessment of on-site hydrogen refuelling stations (450 kg/day of H2) based on different hydrogen sources and production technologies. Green ammonia, biogas, and water have been considered as hydrogen sources while cracking, autothermal reforming, and electrolysis have been selected as the hydrogen production technologies. The electric energy requirements of the hydrogen refuelling stations (HRSs) are internally satisfied using the fuel cell technology as power units for ammonia and biogas-based configurations and the PV grid-connected power plant for the water-based one. The hydrogen purification, where necessary, is performed by means of a Palladium-based membrane unit. Finally, the same hydrogen compression, storage, and distribution section are considered for all configurations. The sizing and the energy analysis of the proposed configurations have been carried out by simulation models adequately developed. Moreover, the economic feasibility has been performed by applying the life cycle cost analysis. The ammonia-based configurations are the best solutions in terms of hydrogen production energy efficiency (>71%, LHV) as well as from the economic point of view, showing a levelized cost of hydrogen (LCOH) in the range of 6.28 EUR/kg to 6.89 EUR/kg, a profitability index greater than 3.5, and a Discounted Pay Back Time less than five years.
Process Simulations and Experimental Studies of CO2 Capture
Authors: Ramón Fernández José
Published: January 2022

Carbon dioxide, whose global emissions into the atmosphere have reached a maximum of about 36 billion tons per year (compared to the 6 billion tons emitted in 1950), is considered by far the main greenhouse gas (GHG) [...]
Thermodynamics and Kinetic Modeling of the ZnSO4·H2O Thermal Decomposition in the Presence of a Pd/Al2O3 Catalyst
Authors: Kurban Gabriela V. T. , Rego Artur S. C. , Mello Nathalli M. , Brocchi Eduardo A. , Navarro Rogério C. S. , Souza Rodrigo F. M.
Published: January 2022

The sulfur–iodine thermochemical water-splitting cycle is a promising route proposed for hydrogen production. The decomposition temperature remains a challenge in the process. Catalysts, such as Pd supported on Al2O3, are being considered to decrease reaction temperatures. However, little is known regarding the kinetic behavior of such systems. In this work, zinc sulfate thermal decomposition was studied through non-isothermal thermogravimetric analysis to understand the effect of a catalyst within the sulfur–iodine reaction system context. The findings of this analysis were also related to a thermodynamic assessment. It was observed that the presence of Pd/Al2O3 modified the reaction mechanism, possibly with some intermediate reactions that were suppressed or remarkably accelerated. The proposed model suggests that zinc sulfate transformation occurred in two sequential stages without the Pd-based material. Activation energy values of 238 and 368 kJ·mol−1 were calculated. In the presence of Pd/Al2O3, an activation energy value of 204 kJ·mol−1 was calculated, which is lower than observed previously.
Hydrodynamics of Moonpool-Type Floaters: A Theoretical and a CFD Formulation
Authors: Mavrakos Anargyros S. , Konispoliatis Dimitrios N. , Ntouras Dimitrios G. , Papadakis George P. , Mavrakos Spyros A.
Published: January 2022

Moonpool-type floaters were initially proposed for applications such as artificial islands or as protecting barriers around a small area enabling work at the inner surface to be carried out in relatively calm water. In recent years, a growing interest on such structures has been noted, especially in relation to their use as heaving wave energy converters or as oscillating water column (OWC) devices for the extraction of energy from waves. Furthermore, in the offshore marine industry, several types of vessels are frequently constructed with moonpools. The present paper deals with the hydrodynamics of bottomless cylindrical bodies having vertical symmetry axis and floating in a water of finite depth. Two computation methods were implemented and compared: a theoretical approach solving analytically the corresponding diffraction problem around the moonpool floater and a computational fluid dynamics (CFD) solver, which considers the viscous effects near the sharp edges of the body (vortex shedding) as non-negligible. Two different moonpool-type configurations were examined, and some interesting phenomena were discussed concerning the viscous effects and irregularities caused by the resonance of the confined fluid.
Deep Learning Prediction for Rotational Speed of Turbine in Oscillating Water Column-Type Wave Energy Converter
Authors: Roh Chan , Kim Kyong-Hwan
Published: January 2022

This study uses deep learning algorithms to predict the rotational speed of the turbine generator in an oscillating water column-type wave energy converter (OWC-WEC). The effective control and operation of OWC-WECs remain a challenge due to the variation in the input wave energy and the significantly high peak-to-average power ratio. Therefore, the rated power control of OWC-WECs is essential for increasing the operating time and power output. The existing rated power control method is based on the instantaneous rotational speed of the turbine generator. However, due to physical limitations, such as the valve operating time, a more refined rated power control method is required. Therefore, we propose a method that applies a deep learning algorithm. Our method predicts the instantaneous rotational speed of the turbine generator and the rated power control is performed based on the prediction. This enables precise control through the operation of the high-speed safety valve before the energy input exceeds the rated value. The prediction performances for various algorithms, such as a multi-layer perceptron (MLP), recurrent neural network (RNN), long short-term memory (LSTM), and convolutional neural network (CNN), are compared. In addition, the prediction performance of each algorithm as a function of the input datasets is investigated using various error evaluation methods. For the training datasets, the operation data from an OWC-WEC west of Jeju in South Korea is used. The analysis demonstrates that LSTM exhibits the most accurate prediction of the instantaneous rotational speed of a turbine generator and CNN has visible advantages when the data correlation is low.
Modeling and Optimization of Smart Building Energy Management System Considering Both Electrical and Thermal Load
Authors: Khan Muhammad Hilal , Asar Azzam Ul , Ullah Nasim , Albogamy Fahad R. , Rafique Muhammad Kashif
Published: January 2022

Energy consumption in buildings is expected to increase by 40% over the next 20 years. Electricity remains the largest source of energy used by buildings, and the demand for it is growing. Building energy improvement strategies is needed to mitigate the impact of growing energy demand. Introducing a smart energy management system in buildings is an ambitious yet increasingly achievable goal that is gaining momentum across geographic regions and corporate markets in the world due to its potential in saving energy costs consumed by the buildings. This paper presents a Smart Building Energy Management system (SBEMS), which is connected to a bidirectional power network. The smart building has both thermal and electrical power loops. Renewable energy from wind and photo-voltaic, battery storage system, auxiliary boiler, a fuel cell-based combined heat and power system, heat sharing from neighboring buildings, and heat storage tank are among the main components of the smart building. A constraint optimization model has been developed for the proposed SBEMS and the state-of-the-art real coded genetic algorithm is used to solve the optimization problem. The main characteristics of the proposed SBEMS are emphasized through eight simulation cases, taking into account the various configurations of the smart building components. In addition, EV charging is also scheduled and the outcomes are compared to the unscheduled mode of charging which shows that scheduling of Electric Vehicle charging further enhances the cost-effectiveness of smart building operation.
Design and Numerical Simulation of Biomimetic Structures to Capture Particles in a Microchannel
Authors: Yang Lung-Jieh , Joseph Vivek-Jabaraj , Unnam Neethish-Kumar , Esakki Balasubramanian
Published: January 2022

The study of separating different sizes of particles through a microchannel has been an interest in recent years and the primary attention of this study is to isolate the particles to the specific outlets. The present work highly focuses on the design and numerical analysis of a microchip and the microparticles capture using special structures like corrugated dragonfly wing structure and cilia walls. The special biomimetic structured corrugated wing is taken from the cross-sectional area of the dragonfly wing and cilia structure is obtained from the epithelium terminal bronchioles to the larynx from the human body. Parametric studies were conducted on different sizes of microchip scaled and tested up in the range between 2–6 mm and the thickness was assigned as 80 µm in both dragonfly wing structure and cilia walls. The microflow channel is a low Reynolds number regime and with the help of the special structures, the flow inside the microchannel is pinched and a sinusoidal waveform pattern is observed. The pinched flow with sinusoidal waveform carries the particles downstream and induces the particles trapped in desired outlets. Fluid particle interaction (FPI) with a time-dependent solver in COMSOL Multiphysics was used to carry out the numerical study. Two particle sizes of 5 µm and 20 µm were applied, the inlet velocity of 0.52 m/s with an inflow angle of 50° was used throughout the study and it suggested that: the microchannel length of 3 mm with corrugated dragonfly wing structure had the maximum particle capture rate of 20 µm at the mainstream outlet. 80% capture rate for the microchannel length of 3 mm with corrugated dragonfly wing structure and 98% capture rate for the microchannel length of 2 mm with cilia wall structure were observed. Numerical simulation results showed that the cilia walled microchip is superior to the corrugated wing structure as the mainstream outlet can conduct most of the 20 µm particles. At the same time, the secondary outlet can laterally capture most of the 5 µm particles. This biomimetic microchip design is expected to be implemented using the PDMS MEMS process in the future.
Determinants of Preference and Consumption of Healthy Food in Children
Authors: Laureati Monica
Published: January 2022

According to recent findings, action is urgently needed to promote healthy eating habits among children, especially to increase daily consumption of fresh fruits and vegetables [...]
Analysing Historical and Modelling Future Soil Temperature at Kuujjuaq, Quebec (Canada): Implications on Aviation Infrastructure
Authors: Leung Andrew C. W. , Gough William A. , Mohsin Tanzina
Published: January 2022

The impact of climate change on soil temperatures at Kuujjuaq, Quebec in northern Canada is assessed. First, long-term historical soil temperature records (1967–1995) are statistically analyzed to provide a climatological baseline for soils at 5 to 150 cm depths. Next, the nature of the relationship between atmospheric variables and soil temperature are determined using a statistical downscaling model (SDSM) and National Centers for Environmental Prediction (NCEP), a climatological data set. SDSM was found to replicate historic soil temperatures well and used to project soil temperatures for the remainder of the century using climate model output Canadian Second Generation Earth System Model (CanESM2). Three Representative Concentration Pathway scenarios (RCP 2.6, 4.5 and 8.5) were used from the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report (AR5). This study found that the soil temperature at this location may warm at 0.9 to 1.2 °C per decade at various depths. Annual soil temperatures at all depths are projected to rise to above 0 °C for the 1997–2026 period for all climate scenarios. The melting soil poses a hazard to the airport infrastructure and will require adaptation measures.
On the Nonlocal Problems in Time for Time-Fractional Subdiffusion Equations
Authors: Ashurov Ravshan , Fayziev Yusuf
Published: January 2022

The nonlocal boundary value problem, dtρu(t)+Au(t)=f(t) (0<ρ<1, 0<t≤T), u(ξ)=αu(0)+φ (α is a constant and 0<ξ≤T), in an arbitrary separable Hilbert space H with the strongly positive selfadjoint operator A, is considered. The operator dt on the left hand side of the equation expresses either the Caputo derivative or the Riemann–Liouville derivative; naturally, in the case of the Riemann–Liouville derivatives, the nonlocal boundary condition should be slightly changed. Existence and uniqueness theorems for solutions of the problems under consideration are proved. The influence of the constant α on the existence of a solution to problems is investigated. Inequalities of coercivity type are obtained and it is shown that these inequalities differ depending on the considered type of fractional derivatives. The inverse problems of determining the right-hand side of the equation and the function φ in the boundary conditions are investigated.
Heterotopic and Neo-Victorian Affinities: Introducing the Special Issue on Neo-Victorian Heterotopias
Authors: Kohlke Marie-Luise , Ho Elizabeth , Suwa Akira
Published: January 2022

The introduction to this special issue on Neo-Victorian Heterotopias investigates the affinities between the spaces designated by Michel Foucault’s ambivalent and protean concept of ‘heterotopia’ and the similarly equivocal, shifting, and adaptable cultural phenomenon of ‘neo-Victorianism’. In both cases, cultural spaces and/or artefacts prove deeply intertwined with chronicity, at once juxtaposing and blending different temporal moments, past and present. Socially produced sites of distinct emplacement are exposed not just as culturally and historically contingent constructs, but simultaneously enable forms of resistance to the prevailing ideologies that call them into being. The fertile exercise of considering heterotopias and neo-Victorianism in conjunction opens up new explorations of the Long Nineteenth Century and its impact on today’s cultural imaginary, memory and identity politics, contestations of systemic historical iniquities, and engagements with forms of difference, non-normativity, and Otherness.
The Effects of Heatwaves on Human Morbidity in Primary Care Settings: A Case-Crossover Study
Authors: Alsaiqali Mahmoud , De Troeyer Katrien , Casas Lidia , Hamdi Rafiq , Faes Christel , Van Pottelbergh Gijs
Published: January 2022

Purpose: This study assesses the potential acute effects of heatwaves on human morbidities in primary care settings. Methods: We performed a time-stratified case-crossover study to assess the acute effects of heatwaves on selected morbidities in primary care settings in Flanders, Belgium, between 2000 and 2015. We used conditional logistic regression models. We assessed the effect of heatwaves on the day of the event (lag 0) and X days earlier (lags 1 to X). The associations are presented as Incidence Density Ratios (IDR). Results: We included 22,344 events. Heatwaves are associated with increased heat-related morbidities such as heat stroke IDR 3.93 [2.94–5.26] at lag 0, dehydration IDR 3.93 [2.94–5.26] at lag 1, and orthostatic hypotension IDR 2.06 [1.37–3.10] at lag 1. For cardiovascular morbidities studied, there was only an increased risk of stroke at lag 3 IDR 1.45 [1.04–2.03]. There is no significant association with myocardial ischemia/infarction or arrhythmia. Heatwaves are associated with decreased respiratory infection risk. The IDR for upper respiratory infections is 0.82 [0.78–0.87] lag 1 and lower respiratory infections (LRI) is 0.82 [0.74–0.91] at lag 1. There was no significant effect modification by age or premorbid chronic disease (diabetes, hypertesnsion). Conclusion: Heatwaves are associated with increased heat-related morbidities and decreased respiratory infection risk. The study of heatwaves’ effects in primary care settings helps evaluate the impact of heatwaves on the general population. Primary care settings might be not suitable to study acute life-threatening morbidities.
Detection of Upper Limb Asymmetries in Athletes According to the Stage of the Season—A Longitudinal Study
Authors: Velarde-Sotres Álvaro , Bores-Cerezal Antonio , Mecías-Calvo Marcos , Barcala-Furelos Martín , Aparicio-Obregón Silvia , Calleja-González Julio
Published: January 2022

Sports injuries can affect the performance of athletes. For this reason, functional tests are used for injury assessment and prevention, analyzing physical or physiological imbalances and detecting asymmetries. The main aim of this study was to detect the asymmetries in the upper limbs (right and left arms) in athletes, using the OctoBalance Test (OB), depending on the stage of the season. Two hundred and fifty-two participants (age: 23.33 ± 8.96 years old; height: 178.63 ± 11.12 cm; body mass: 80.28 ± 17.61 kg; body mass index: 24.88 ± 4.58; sports experience: 12.52 ± 6.28 years), practicing different sports (rugby, athletics, football, swimming, handball, triathlon, basketball, hockey, badminton and volleyball), assessed with the OB in medial, superolateral, and inferolateral directions in both arms, in four moments of the season (May 2017, September 2017, February 2018 and May 2018). ANOVA test was used with repeated measures with a p ≤ 0.05, for the analysis of the different studied variances. Significant differences were found (p = 0.021) in the medial direction of the left arm, between the first (May 2017) and fourth stages (May 2018), with values of 71.02 ± 7.15 cm and 65.03 ± 7.66 cm. From the detection of asymmetries, using the OB to measure, in the medial, superolateral and inferolateral directions, mobility and balance can be assessed. In addition, it is possible to observe functional imbalances, as a risk factor for injury, in each of the stages into which the season is divided, which will help in the prevention of injuries and in the individualization of training.
Perceived Stress at Work and Associated Factors among E-Waste Workers in French-Speaking West Africa
Authors: Kêdoté Nonvignon Marius , Sopoh Ghislain Emmanuel , Tobada Steve Biko , Darboux Aymeric Joaquin , Fonton Pérince , Sanon Lompo Marthe Sandrine , Fobil Julius
Published: January 2022

Perceived stress at work is an important risk factor that affects the mental and physical health of workers. This study aims to determine the prevalence and factors associated with perceived stress in the informal electronic and electrical equipment waste processing sector in French-speaking West Africa. From 14 to 21 November 2019, a cross-sectional survey was carried out among e-waste workers in five countries in the French-speaking West African region, and participants were selected by stratified random sampling. Participants were interviewed on socio-demographic variables and characteristics related to e-waste management activities using a questionnaire incorporating Cohen’s Perceived Stress Scale (10-item version). Factors associated with perceived stress were determined by multivariate logistic regression. A total of 740 e-waste workers were interviewed. The mean age of the workers was 34.59 ± 11.65 years, with extremes of 14 and 74 years. Most of the interviewees were repairers (43.11%). The prevalence of perceived stress among the e-waste workers was 76.76%. Insufficient income, number of working days per week, perceived violence at work, and the interference of work with family responsibilities or leisure were the risk factors that were the most associated with perceived stress. The high prevalence of perceived stress and its associated factors call for consideration and improvement of the working conditions of e-waste workers.
The Relationship between VO2 and Muscle Deoxygenation Kinetics and Upper Body Repeated Sprint Performance in Trained Judokas and Healthy Individuals
Authors: Antunes André , Domingos Christophe , Diniz Luísa , Monteiro Cristina P. , Espada Mário C. , Alves Francisco B. , Reis Joana F.
Published: January 2022

The present study sought to investigate if faster upper body oxygen uptake (VO2) and hemoglobin/myoglobin deoxygenation ([HHb]) kinetics during heavy intensity exercise were associated with a greater upper body repeated-sprint ability (RSA) performance in a group of judokas and in a group of individuals of heterogenous fitness level. Eight judokas (JT) and seven untrained healthy participants (UT) completed an incremental step test, two heavy intensity square-wave transitions and an upper body RSA test consisting of four 15 s sprints, with 45 s rest, from which the experimental data were obtained. In the JT group, VO2 kinetics, [HHb] kinetics and the parameters determined in the incremental test were not associated with RSA. However, when the two groups were combined, the amplitude of the primary phase VO2 and [HHb] were positively associated with the accumulated work in the four sprints (ΣWork). Additionally, maximal aerobic power (MAP), peak VO2 and the first ventilatory threshold (VT1) showed a positive correlation with ΣWork and an inverse correlation with the decrease in peak power output (Dec-PPO) between the first and fourth sprints. Faster VO2 and [HHb] kinetics do not seem to be associated with an increased upper body RSA in JT. However, other variables of aerobic fitness seem to be associated with an increased upper body RSA performance in a group of individuals with heterogeneous fitness level.
A Review on Aging, Sarcopenia, Falls, and Resistance Training in Community-Dwelling Older Adults
Authors: Rodrigues Filipe , Domingos Christophe , Monteiro Diogo , Morouço Pedro
Published: January 2022

As aging continues to grow in our society, sarcopenia and associated fall risk is considered a public health problem since falling is the third cause of chronic disability. Falls are negatively related to functionality and independence and positively associated with morbidity and mortality. The cost of treatment of secondary injuries related to falls is high. For example, one in ten fall incidents leads to bone fractures and several other comorbidities. As demonstrated by several experimental studies, adopting a more active lifestyle is critical for reducing the number of fall episodes and their consequences. Therefore, it is essential to debate the proven physical exercise methods to reduce falls and fall-related effects. Since muscle mass, muscle strength, bone density, and cartilage function may play significant roles in daily activities, resistance training may positively and significantly affect the elderly. This narrative review aimed to examine current evidence on existing resistance training using resistance machines and bodyweight or low-cost equipment for the elderly and how they are related to falls and fall-related consequences. We provide theoretical links between aging, sarcopenia, and falls linking to resistance training and offer practical suggestions to exercise professionals seeking to promote regular physical exercise to promote quality of life in this population. Exercise programs focusing on strength may significantly influence muscle mass and muscle strength, minimizing functional decline and risk of falling. Resistance training programs should be customized to each elderly according to age, sex, and other fundamental and individual aspects. This narrative review provides evidence to support recommendations for practical resistance training in the elderly related to intensity and volume. A properly designed resistance training program with adequate instructions and technique is safe for the elderly. It should include an individualized approach based on existing equipment (i.e., body weight, resistance machines). Existing literature shows that exercise performance towards 2–3 sets of 1–2 exercises per major muscle group, performing 5–8 repetitions or achieving intensities of 50–80% of 1RM, 2–3 times per week should be recommended, followed by training principles such as periodization and progression. Bearing this in mind, health and exercise professionals should combine efforts focusing on efficient strategies to reduce falls among the elderly and promote higher experiences of well-being at advanced stages in life.
Intention to Exclusively Breastfeed Is Associated with Lower Rates of Cesarean Section for Nonmedical Reasons in a Cohort of Mothers in Vietnam
Authors: Duong Doan Thi Thuy , Binns Colin , Lee Andy , Zhao Yun , Pham Ngoc Minh , Hoa Dinh Thi Phuong , Ha Bui Thi Thu
Published: January 2022

Background: Breastfeeding brings benefits to both mothers and children in the short term and long term. Unnecessary cesarean sections can bring risks to both parties. This study was undertaken to examine the relationship between exclusive breastfeeding intention and cesarean delivery. Methods: We analyzed data collected from 554 single mothers who delivered in Dong Anh General District Hospital or Hanoi Obstetrics and Gynecology Hospital, Vietnam, in 2020–2021. The relationship between exclusive breastfeeding intention and cesarean delivery for nonmedical reasons was adjusted for maternal education, maternal age, parity, history of fetal loss, having at least eight antenatal contacts, hospital of delivery, child sex, and birth weight. Results: Antenatally, 34.8% (184/529) of mothers intended to breastfeed exclusively until 6 months and 30.8% (84/274) underwent cesarean section for a nonmedical reason. After adjusting for other factors, mothers who intended to breastfeed exclusively until 6 months were less likely to undergo cesarean delivery for nonmedical reasons (OR = 0.55, 95% CI: 0.31–0.96, p = 0.034). Conclusions: This study adds to the growing evidence related to unnecessary cesarean sections and routine over-medicalization of normal birth in the urban areas of Vietnam. The association between breastfeeding intentions and a lower rate of cesarean section suggests that education on breastfeeding could be a useful intervention for reducing the rate of cesarean sections and improving maternal and child health.
Validation of the Orgasm Rating Scale in Context of Sexual Relationships of Gay and Lesbian Adults
Authors: Mangas Pablo , Granados Reina , Cervilla Oscar , Sierra Juan Carlos
Published: January 2022

Currently, no validated instrument exists for assessing the subjective experience of orgasm in the gay population. The Orgasm Rating Scale (ORS), previously validated in the heterosexual population, comprises four dimensions: Affective, Sensory, Intimacy, and Rewards. This study validated it for sexual relationships in the gay population by obtaining its factorial invariance by sexual orientation and sex, its internal consistency reliability, and evidence of validity in its relationship with other variables. We assessed 1600 cisgender Spanish adults–heterosexuals, gays, and lesbians–divided into 4, sex-based groups of 400 each, according to the Kinsey scale scores. Participants reported recent experiences of orgasm in the context of sexual relationships and responded to the ORS and other scales assessing attitude toward sexual fantasies and sexual functioning. The ORS structure showed a strict multigroup-level invariance by sexual orientation and sex, confirming its four-dimensional structure. The subjective orgasm intensity was associated with a positive attitude toward sexual fantasies and sexual functioning. Scores obtained on the Affective, Intimacy, and Rewards dimensions confirmed the ability to discriminate between gay people with and without orgasmic difficulties. The ORS’s Spanish version presents good psychometric properties as a validated scale to evaluate the subjective experience of orgasm in the gay population.
The Interplay between Host Defense, Infection, and Clinical Status in Septic Patients: A Narrative Review
Authors: Lazzaro Alessandro , De Girolamo Gabriella , Filippi Valeria , Innocenti Giuseppe Pietro , Santinelli Letizia , Ceccarelli Giancarlo , Trecarichi Enrico Maria , Torti Carlo , Mastroianni Claudio Maria , d’Ettorre Gabriella , Russo Alessandro
Published: January 2022

Sepsis is a life-threatening condition that arises when the body’s response to an infection injures its own tissues and organs. Despite significant morbidity and mortality throughout the world, its pathogenesis and mechanisms are not clearly understood. In this narrative review, we aimed to summarize the recent developments in our understanding of the hallmarks of sepsis pathogenesis (immune and adaptive immune response, the complement system, the endothelial disfunction, and autophagy) and highlight novel laboratory diagnostic approaches. Clinical management is also discussed with pivotal consideration for antimicrobic therapy management in particular settings, such as intensive care unit, altered renal function, obesity, and burn patients.
Identification and Fine Mapping of the Recessive Gene BK-5, Which Affects Cell Wall Biosynthesis and Plant Brittleness in Maize
Authors: Li Qigui , Nie Shujun , Li Gaoke , Du Jiyuan , Ren Ruchang , Yang Xiu , Liu Boyan , Gao Xiaolong , Liu Tianjian , Zhang Zhiming , Zhao Xiangyu , Li Xinzheng , Nie Yongxin , Wang Baichen , Lin Haijian , Ding Haiping , Pan Guangtang
Published: January 2022

The cellulose of the plant cell wall indirectly affects the cell shape and straw stiffness of the plant. Here, the novel brittleness mutant brittle stalk-5 (bk-5) of the maize inbred line RP125 was characterized. We found that the mutant displayed brittleness of the stalk and even the whole plant, and that the brittleness phenotype existed during the whole growth period from germination to senescence. The compressive strength was reduced, the cell wall was thinner, and the cellulose content was decreased compared to that of the wild type. Genetic analysis and map-based cloning indicated that bk-5 was controlled by a single recessive nuclear gene and that it was located in a 90.2-Kb region on chromosome 3 that covers three open reading frames (ORFs). Sequence analysis revealed a single non-synonymous missense mutation, T-to-A, in the last exon of Zm00001d043477 (B73: version 4, named BK-5) that caused the 951th amino acid to go from leucine to histidine. BK-5 encodes a cellulose synthase catalytic subunit (CesA), which is involved with cellulose synthesis. We found that BK-5 was constitutively expressed in all tissues of the germinating stage and silking stage, and highly expressed in the leaf, auricula, and root of the silking stage and the 2-cm root and bud of the germinating stage. We found that BK-5 mainly localized to the Golgi apparatus, suggesting that the protein might move to the plasma membrane with the aid of Golgi in maize. According to RNA-seq data, bk-5 had more downregulated genes than upregulated genes, and many of the downregulated genes were enzymes and transcription factors related to cellulose, hemicellulose, and lignin biosynthesis of the secondary cell wall. The other differentially expressed genes were related to metabolic and cellular processes, and were significantly enriched in hormone signal transduction, starch and sucrose metabolism, and the plant–pathogen interaction pathway. Taken together, we propose that the mutation of gene BK-5 causes the brittle stalk phenotype and provides important insights into the regulatory mechanism of cellulose biosynthesis and cell wall development in maize.
Sugar Metabolism and Transcriptome Analysis Reveal Key Sugar Transporters during Camellia oleifera Fruit Development
Authors: He Yu , Chen Ruifan , Yang Ying , Liang Guichan , Zhang Heng , Deng Xiaomei , Xi Ruchun
Published: January 2022

Camellia oleifera is a widely planted woody oil crop with economic significance because it does not occupy cultivated land. The sugar-derived acetyl-CoA is the basic building block in fatty acid synthesis and oil synthesis in C. oleifera fruit; however, sugar metabolism in this species is uncharacterized. Herein, the changes in sugar content and metabolic enzyme activity and the transcriptomic changes during C. oleifera fruit development were determined in four developmental stages (CR6: young fruit formation; CR7: expansion; CR9: oil transformation; CR10: ripening). CR7 was the key period of sugar metabolism since it had the highest amount of soluble sugar, sucrose, and glucose with a high expression of genes related to sugar transport (four sucrose transporters (SUTs) or and one SWEET-like gene, also known as a sugar, will eventually be exported transporters) and metabolism. The significant positive correlation between their expression and sucrose content suggests that they may be the key genes responsible for sucrose transport and content maintenance. Significantly differentially expressed genes enriched in the starch and sucrose metabolism pathway were observed in the CR6 versus CR10 stages according to KEGG annotation. The 26 enriched candidate genes related to sucrose metabolism provide a molecular basis for further sugar metabolism studies in C. oleifera fruit.
Exosomal and Plasma Non-Coding RNA Signature Associated with Urinary Albumin Excretion in Hypertension
Authors: Riffo-Campos Angela L. , Perez-Hernandez Javier , Ortega Ana , Martinez-Arroyo Olga , Flores-Chova Ana , Redon Josep , Cortes Raquel
Published: January 2022

Non-coding RNA (ncRNA), released into circulation or packaged into exosomes, plays important roles in many biological processes in the kidney. The purpose of the present study is to identify a common ncRNA signature associated with early renal damage and its related molecular pathways. Three individual libraries (plasma and urinary exosomes, and total plasma) were prepared from each hypertensive patient (with or without albuminuria) for ncRNA sequencing analysis. Next, an RNA-based transcriptional regulatory network was constructed. The three RNA biotypes with the greatest number of differentially expressed transcripts were long-ncRNA (lncRNA), microRNA (miRNA) and piwi-interacting RNA (piRNAs). We identified a common 24 ncRNA molecular signature related to hypertension-associated urinary albumin excretion, of which lncRNAs were the most representative. In addition, the transcriptional regulatory network showed five lncRNAs (LINC02614, BAALC-AS1, FAM230B, LOC100505824 and LINC01484) and the miR-301a-3p to play a significant role in network organization and targeting critical pathways regulating filtration barrier integrity and tubule reabsorption. Our study found an ncRNA profile associated with albuminuria, independent of biofluid origin (urine or plasma, circulating or in exosomes) that identifies a handful of potential targets, which may be utilized to study mechanisms of albuminuria and cardiovascular damage.