bluuebunny/crossref_metadata_2025 huggingface dataset:
System Reliability Based Design Optimization of Truss Structures with Interval Variables
Authors: Zaeimi Mohammad , Ghoddosain Ali
Published: December 2019

New products ranging from simple components to complex structures should be designed to be optimal and reliable. In this paper, for the first time, a hybrid uncertain model is applied to system reliability based design optimization (RBDO) of trusses. All uncertain variables are described by random distributions but those lack information are defined by variation intervals. For system RBDO of trusses, the first order reliability method, as well as an equivalent model and the branch and bound method, are utilized to determine the system failure probability; and Improved (μ + λ) constrained differential evolution (ICDE) is employed for the optimization process. Reliability assessment of some engineering examples is proposed to verify our results. Moreover, the effect interval variables on the optimum weight of the truss structures are investigated. The results indicate that the optimal weight depends not only on the uncertainty level but also on the equivalent standard deviation; and a falling-rising behavior is observed.
SWOT Analysis of the Air Transport Fleet in the Hungarian Defence Forces
Authors: Boldizsár Adrienn , Kővári Botond
Published: December 2019

Nowadays it is almost unthinkable, that the forces of the army can not deliver the resuply to the troops by air, especially for large distances. This can not be solved by sea or inland transportation, or if it does, it will take unnecessary time or less security. Although the Hungarian Defense Forces have their own transportation fleet, the fleet reserved for this purpose is currently very modest, and there are several reasons why it should be expanded. Developing an own airline fleet is currently a very topical issue. Previously operated Antonov 26 aircraft have little ability to perform the tasks, or in many cases cannot. The two Airbus A319 aircraft purchased in February and Falcon type aircraft purchased in August, although improves the situation, they still do not fill the gap, there are a number of deficiencies in this area. For this I did a SWOT analysis, and with its help we can define the opportunities and threats of development of domestic military air transport.
Uspješnost poslovanja ruralnog turizma u Hrvatskoj
Authors: Očić Vesna , Mudri Bonita , Grgić Ivo , Šakić Bobić Branka
Published: December 2019

Ruralno područje čini 92% površine Republike Hrvatske i u posljednjim desetljećima je suočeno s jakim depopulacijskim trendovima. Jedan od mogućih odgovora na ovaj problem je jačanje turističke ponude u ruralnom području koja bi omogućila održiv razvoj ruralnog prostora, ponudu radnih mjesta i unaprjeđenje standarda stanovnika. Cilj ovoga rada je metodom studije slučaja prikazati obiteljsko poljoprivredno gospodarstvo koje nudi agroturističku uslugu na području grada Daruvara. Analizirano gospodarstvo proizvodi grožđe i vino, te se od 2008. godine bavi i agroturizmom. Registrirano je kao vinotočje, a nudi i mogućnost noćenja kapaciteta četiri osobe. Gospodarstvo je promatrano od 2013. do 2017. godine, te je u navedenom razdoblju poslovalo iznad granice ekonomičnosti, uz iznimku 2016. godine kada su zabilježene ekstremne klimatske prilike. Prosječna rentabilnost gospodarstva u promatranom je razdoblju bila 7%, a kretala se od -13% (2016. godine), čemu su uzrok nepovoljne klimatske prilike te godine, do najvećih 18% 2013. godine, dok se ostvareni broj noćenja povećavao od 50 (2013. godine) do 85 godišnje (2017. godine). Za povećanje uspješnosti poslovanja agroturističkog gospodarstva svakako je potrebno raditi na povećanju popunjenosti kapaciteta, za što su potrebne šire marketinške aktivnosti.
Novos desafios para velhos problemas: o enfermeiro especialista em Enfermagem de Reabilitação na promoção da acessibilidade
Authors: Ferreira da Silva Carina , Barros de Oliveira Fábio Daniel , Ribeiro Marlene Patrícia , Pereira Prazeres Virgínia Maria , Pimenta Lopes Ribeiro Olga Maria
Published: December 2019

Enquadramento: A acessibilidade constitui um elemento crucial na qualidade de vida das pessoas com mobilidade condicionada, sendo imprescindível para o exercício dos seus direitos. A sua efetividade envolve uma equipa multidisciplinar, que deverá incluir o Enfermeiro Especialista em Enfermagem de Reabilitação, dado que a este compete capacitar a pessoa com mobilidade condicionada para a reinserção e exercício da cidadania.
Objetivos: Refletir sobre os direitos das pessoas com mobilidade condicionada; compreender a intervenção do Enfermeiro Especialista em Enfermagem de Reabilitação na promoção da acessibilidade e na inclusão social.
Principais tópicos em análise: Legislação e planos de promoção da acessibilidade e da inclusão social; e a intervenção do Enfermeiro Especialista em Enfermagem de Reabilitação no âmbito destas problemáticas.
Conclusão: As condições de acessibilidade constituem um dos fatores discriminatórios para as pessoas com mobilidade condicionada. Assim, compete ao Enfermeiro Especialista em Enfermagem de Reabilitação paralelamente com as entidades competentes, encarar esta problemática como uma urgente oportunidade para a mudança.
Palavras-chave: Acessibilidade Arquitetônica; Enfermagem em Reabilitação; Limitação da Mobilidade; Pessoas com Deficiência.
Documentação dos cuidados de enfermagem durante o processo de morrer - como se diferenciam os enfermeiros de reabilitação?
Authors: Cardoso Maria Filomena , Martins Maria Manuela , Ribeiro Olga
Published: December 2019

Objetivo: analisar os focos/diagnósticos de enfermagem documentados pelos enfermeiros especialistas em enfermagem de reabilitação, durante o processo de morrer em contexto hospitalar. Método: estudo descritivo, retrospetivo e quantitativo realizado numa instituição hospitalar do norte de Portugal em fevereiro de 2017. Os dados sobre a documentação dos focos/diagnósticos de enfermagem identificados nos clientes que morreram no ano de 2016 foram recolhidos por meio de dois sistemas de informação: SClínico e BICUcare. Resultados: nos 4115 registos efetuados por 148 enfermeiros especialistas em enfermagem de reabilitação, constatamos que apesar da evolução ocorrida durante a última década, na documentação dos cuidados de enfermagem, sobressaem algumas inquietações sobre qual a prática de cuidados que a mesma evidencia. Decorrente da ênfase colocada na documentação das alterações no domínio da função, os enfermeiros especialistas em enfermagem de reabilitação tendem a subestimar o registo das alterações e das necessidades que emergem das transições vivenciadas pelas pessoas, especificamente durante a morte e os processos de morrer. Conclusão: Atendendo a que a informação registada contribui para a visibilidade dos cuidados prestados, emerge a necessidade de se adotarem estratégias que resolvam o problema da subdocumentação, nomeadamente perante a morte e os processos de morrer. Descritores: Morte; Enfermagem; Enfermagem em Reabilitação; Registros Eletrónicos de Saúde; Diagnóstico de Enfermagem
Ochoa, José y Sotillos, Luis: «101 Claves de Tecnología de la Información» (Recensión)
Authors: Merino Merchán José F.
Published: December 2019

Recensión de la obra: Ochoa, José y Sotillos, Luis. 101 Claves de Tecnologías de la Información. Madrid, Pearson Prentice Hall, 2003, 246 páginas.
Sobre cuestiones normomáticas en un sistema de resolución de conflictos judiciales de garantías efectivas
Authors: Merino Merchán José F.
Published: December 2019

SUMARIO: 1. Elementos notacionales empleados en este trabajo. - 2. Fundamentos lógicos del programa del sistema de resolución de conflictos judiciales. - 3. El factor de racionalidad judicial: expresión veritativo-funcional que relaciona el conflicto judicial, la resolución judicial y la norma aplicable en un supuesto i). - 4. Desviación del factor de racionalidad judicial. - 5. Representación gráfica e ideográfica entre, su desviada o divergente con respecto al error judicial. - 6. El factor de racionalidad judicial en las relaciones ideográficas expuestas en el apartado anterior. - 7. Sobre las diversas maneras de valorar el. - 8. Índices de satisfacción judicial individualizados de los operadores vindicativos e índices de eficiencia judicial de los operadores judiciales.
Arce, A.: «Teoría y práctica de la Junta General del Principado de Asturias» (Recensión)
Authors: De la Peña Rodríguez Luis
Published: December 2019

Recensión de la obra: Arce, A.: «Teoría y práctica de la Junta General del Principado de Asturias». Editado por Madú, Granda-Siero, 2003, 189 págs.
Crónica parlamentaria de la VII Legislatura del Senado. Parte I: años 2000 y 2001
Authors: Martínez Santa María Paloma
Published: December 2019

SUMARIO: I. El inicio de la VII Legislatura. - II. Composición del Senado. - III. Órganos del Senado. 1. Pleno. 2. Diputación Permanente. 3. Mesa de la Cámara. 4. Junta de Portavoces. 5. Grupos territoriales.- IV. Funciones del Senado. A) Función de control. B) Función legislativa. - V. Relaciones Interparlamentarias.
La documentación de la Unión Europea
Authors: Fuentes García Josefa
Published: December 2019

SUMARIO: 1. Introducción. - 2. El Diario Oficial, las Colecciones Documentales y las Publicaciones de la Unión Europea. - 2.1. El Diario Oficial.- 2.2. Las colecciones documentales. -2.2.1. En la Comisión Europea. - 2.2.2. En el Consejo de la UE. - 2.2.3. En el Parlamento Europeo. - 2.2.4. En el Tribunal de Justicia. -2.2.5. Transposición de Directivas. - 2.3. Las publicaciones de la Unión Europea. - 3. Guías que explican cómo manejar con ventaja esta red de documentos y datos.
El último Senador por el Arzobispado de Santiago de Cuba, Manuel Santander y Frutos: 1893-1898
Authors: González del Campo María Isabel
Published: December 2019

SUMARIO: Introducción. - 1. Primeros años. Estudios y formación. - 2. Obispo de La Habana, y Senador por el Arzobispado de Cuba. - 3. La guerra de independencia cubana, 1895-1898. 4. Dimisión de Santander. Regreso a España. - 5. Conclusiones.
Extradición y derechos fundamentales: comentario al artículo 13.3 de la Constitución
Authors: Rovira Antonio
Published: December 2019

Estudio sobre: Extradición y derechos fundamentales (comentario al artículo 13.3 de la Constitución)
Las Cortes de 1834 ante la exclusión del Infante Don Carlos y su línea dinástica
Authors: Moral Roncal Antonio Manuel
Published: December 2019

Notas sobre: Las Cortes de 1834 ante la exclusión del Infante Don Carlos y su línea dinástica
Crónica de la Asamblea Parlamentaria del Consejo de Europa (enero-junio de 2004)
Authors: Stoffel Vallotton Nicole
Published: December 2019

SUMARIO: Introducción. - I. Cuestiones Políticas. Países no miembros. - II. Derechos humanos. -III. Cuestiones jurídicas y penales. - IV. Economía, desarrollo y alimentación. - V Cuestiones sociales y de sanidad. - VI. Educación, ciencia, tecnología y cultura. - VIL medio ambiente, agricultura y administración local. - VIII. Población, refugiados, formación profesional. - IX. Cuestiones administrativas y reglas de procedimiento.
Sarmiento Méndez, Xosé Antón (coord.), Marquina Sánchez, José Ignacio, Fernández Rodríguez, José Julio, Sanjurjo Rivo, Vicente A. y Martínez García, Miryam: «Repensando el autogobierno. Estudios sobre la reforma del Estatuto de Galicia» (Recensión)
Authors: Vázquez Gestal Juan José
Published: December 2019

Recensión de la obra VV.AA: Sarmiento Méndez, Xosé Antón (coord.), Marquina Sánchez, José Ignacio, Fernández Rodríguez, José Julio, Sanjurjo Rivo, Vicente A. y Martínez García, Miryam, Repensando el autogobierno. Estudios sobre la reforma del Estatuto de Galicia (Universidad de Vigo, 2005), 269 pp.
La comunidad jurídica, garante de la calidad técnica de las leyes
Authors: Fernández-Carnicero González Claro José , De Andrés Blasco Javier
Published: December 2019

Sobre la comunidad jurídica, garante de la calidad técnica de las leyes
Magnicidio, entierro y funerales del Excmo. Sr. D. José Canalejas y Méndez, Presidente del Consejo de Ministros y Expresidente del Congreso de los Diputados
Authors: Valenzuela de las Heras Susana
Published: December 2019

SUMARIO: Biografía. Precedentes. I. Conceptuación del acto. II. Pre-programa. III. Símbolos. I V. Invitados: clases y su clasificación. V. Programa definitivo-cronograma. VI. Otros actos que tuvieron lugar. VII. Seguridad. VIII. Planificación. Conclusiones. Bibliografía y fuentes.
Informe sobre la propuesta de reforma de Estatuto de Autonomía de la Comunidad Valenciana
Authors: Peñaranda Ramos José Luis
Published: December 2019

Informe sobre la propuesta de reforma de Estatuto de Autonomía de la Comunidad Valenciana
Voto electrónico y garantías electorales: las recientes experiencias en Brasil y en España
Authors: Delgado-Iribarren García-Campero Manuel
Published: December 2019

SUMARIO: I.- Introducción. II.- Las Diferentes Modalidades de Voto Electrónico. III.- Las Garantías Electorales Mínimas que Debe Respetar toda Votación Electrónica. IV.-El Voto Mediante Urna Electrónica en el Referéndum Celebrado en Brasil el 23 de Octubre de 2005. IV.1.- El proceso de elaboración e implantación de la urna electrónica. IV.2.- Descripción del sistema. IV.3.- Valoración del sistema. V- La Prueba de Voto por Internet en el Referéndum sobre el Tratado por el que se Establece una Constitución para Europa celebrado en España el 20 de febrero de 2005. V1.- Características de la prueba. V.2.- Valoración del sistema. VI.- A Modo de Conclusión
Constitución de Lituania
Authors: Méndez López Luis Ángel
Published: December 2019

Estudio introductorio a la Constitución de Lituania
Los códigos éticos en el marco de las Administraciones Públicas contemporáneas: valores para un buen gobierno
Authors: Diego Bautista Óscar
Published: December 2019

Nota sobre “los códigos éticos en el marco de las Administraciones Públicas contemporáneas. Valores para un buen gobierno”
Las paradojas del derecho de asociación en España:
Authors: Fernández Segado Francisco
Published: December 2019

SUMARIO: 1. Introducción. 2. La libertad negativa de asociación y laadscripción obligatoriaa los entes públicos asociativos. 3. El régimen de constitución y adquisición de personalidad jurídica de los partidos. 4. Reflexión final.
Symptomatology of Depression and Anxiety After Ischemic Stroke in Different Evolution Periods
Authors: Fernandes Nicola Teixeira , Costa Paula , Dos Santos Natalie de Nóbrega , Reis Alexandra Isabel
Published: December 2019

Background: Several studies suggest a high prevalence of symptoms of depression and anxiety after stroke. However, the prevalence and severity of this symptomatology may vary according to the period after a stroke in which the patient is assessed. Goals: This study aims to compare the depressive and anxious symptoms of a population of patients who suffered from ischemic stroke and who are in different evolution periods after stroke.Methods: This is an observational cross-sectional study. Participants were all individuals with ischemic stroke, without previous history of psychiatric disease nor pathologies involving Central Nervous System compromise or cognitive deficits, recruited from hospitals or from support units of the Rede Regional de Cuidados Continuados Integrados of the Região Autónoma da Madeira, Portugal. Participants were divided into four groups according to the post- stroke evolution period: short duration (0 to 3 months after the stroke), medium duration (4 to 12 months), chronic period I (13 to 24 months) and chronic period II (more than 24 months after the stroke). Data were collected by a psychologist, with the Beck Depression Inventory (BDI-II) and the State-Trait Anxiety Inventory, Form Y (STAI-Y), in individual self-report sessions. Results: The study included 42 patients with ischemic stroke, 52.4% males, aged 55-88 years. The different post-stroke evolution period groups do not differ in age, sex, level of education, hemispheric location of the lesion or cognitive functioning. The results showed that the prevalence of depression is higher in the chronic group II; regarding the prevalence of anxiety, no significant differences were found between the four groups. As for the severity of symptoms of depression, it is also significantly higher in the chronic group II. With regard to anxiety, trait and state anxiety levels are higher in the medium duration group compared to participants in the short duration period. It was also observed higher levels of state anxiety in the medium duration group compared to the chronic group I. Discussion: These results suggest the need to identify early emotional changes inherent to this population. These changes can have a major impact on the assessment, follow-up and neuropsychological rehabilitation of patients, so that their early identification will allow a more adequate intervention.Keywords: Ischemic stroke; Depression; Anxiety; Emotional changes.
Risks & Challenges: Effectiveness Assessment of a Preventive Program on Addictive Behaviors and Dependencies amongst Students in Higher Education
Authors: Rocha Carla Adriana , Becoña Elisardo , Cardoso Gizela Sousa
Published: December 2019

Background: There is relevant scientific evidence supporting the need to invest in preventing the use of psychoactive substances in higher education, particularly amongst first-year university students.Goals: The purpose of this research was to assess the effectiveness of an original prevention program, the Risks & Challenges, in reducing psychoactive substance use and its negative consequences, as well as to assess its effectiveness in reducing the exposure to risk factors and enhancing the effect of protection factors related to addictive behaviors among university students.Methods: This is a community based open-label controlled trial. The sample consisted of first-year students from the University of Minho, in Portugal, who voluntarily enrolled in the Risks & Challenges Program. Data were collected at baseline, post-intervention and at a 6-months follow-up. Students were randomly assigned to intervention and control groups. In addition to collecting sociodemographic and psychoactive substance-use data, the following instruments were self-administered: AUDIT, Self-Control Scale, Sensation Seeking Scale Version V, Academic Experience Questionnaire, Rosenberg Global Self-esteem Scale and Beck Depression Inventory. Results: The study involved 228 students. Students allocated to the intervention group (n = 98) reported a significant reduction in alcohol consumption as well as in the expectations for cannabis and alcohol use. Furthermore, the intervened students improved in personal and interpersonal dimensions of academic experiences and in self-esteem, with significant decrease of depression, anger and tension indicators. Discussion: These findings support the conclusion that the Risks & Challenges Program can be a valuable tool for preventing drug use in first-year university students. Significant preventive effects were found, reinforcing the relevance of using this program among higher-education students. Keywords: Prevention, Addiction, Risk behavior, Effectiveness evaluation, Adolescents.
Na Beira dos Rios, a Margem da Cidade: Configurações do Trabalho Feminino na Cidade de Teresina-PI (década de 1970)
Authors: Meneses da Silva Yasminn Escórcio , De Sousa Neto Marcelo
Published: December 2019

Recebido:   10/03/2019 Aprovado:   28/05/2019Publicado:  10/07/2019O presente artigo discute as novas configurações de trabalho na cidade de Teresina, por meio da análise do trabalho das lavadeiras de roupa dos rios Parnaíba e Poti, rios que atravessam a cidade, bem como o crescente número dessas mulheres que se dedicavam a essa tarefa, como forma de garantir seu sustento e de sua família. Observou-se que o crescimento do quantitativo de mulheres que se dedicavam a essa atividade esteve relacionado a um forte processo migratório e de crescimento populacional da cidade. O recorte temporal da pesquisa, delimitado como a década de 1970, foi definido por corresponder ao período em que Teresina experienciou um forte processo de transformação de espaços, no interior de uma política de construção de grandes obras, financiadas pelo estado, modificando as formas e oportunidades de trabalho na cidade. Desta forma, se pôde verificar a alteração no cotidiano de trabalho das lavadeiras que, com a criação das lavanderias comunitárias, foram realocadas para um espaço físico dedicado ao tipo de atividade, motivado também pelo interesse de retirá-las das margens dos rios.  Para essa pesquisa, além do uso de fontes hemerográficas, foi utilizado o diálogo com as fontes orais por meio de entrevistas, baseadas na metodologia da História Oral. Dentro desse contexto, foi possível observar como a cidade se desenvolveu por meio de trabalhos informais, a exemplo das lavadeiras, que movimentaram a economia e o crescimento da capital.Palavras-chave: História, Cidade e Trabalho.
Aspectos históricos do surgimento da Contabilidade no mundo e no Brasil: a relação da contabilidade com a legislação vigente
Authors: Tomaz de Aquino João Américo , Lema Mazzafera Bernadete
Published: December 2019

Recebido:   12/05/2019 Aprovado:   23/06/2019Publicado:  10/07/2019Neste estudo são apresentados aspectos históricos do surgimento da contabilidade, desde o surgimento das primeiras formas de controles rudimentares observadas na Mesopotâmia até os dias atuais da contabilidade no Brasil aborda-se a evolução da contabilidade atrelada a legislação vigente por meio de uma revisão da literatura. Conclui-se que o curso de graduação em Ciências Contábeis deve ensejar condições para que o futuro contabilista seja capacitado para compreender as questões científicas, técnicas, sociais, econômicas e financeiras em âmbito nacional e internacional e nos diferentes modelos de organizações. Deve exercer suas responsabilidades com o expressivo domínio das funções contábeis, que revelem conhecimento do cenário econômico e financeiro, nacional e internacional, de forma a proporcionar a harmonização das normas e padrões internacionais de contabilidade, em conformidade com a formação exigida pela Organização Mundial do Comércio e pelas peculiaridades das organizações governamentais.Palavras-chave: Aspectos históricos. Brasil. Contabilidade. Legislação.
Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering
Authors: Wei Zeng , Shi Xianai , Lian Rong , Wang Weibin , Hong Wenrong , Guo Shaobin
Published: December 2019

Gentamicin C1a is an important precursor to the synthesis of etimicin, a potent antibiotic. Wild type Micromonospora purpurea Gb1008 produces gentamicin C1a, besides four other gentamicin C components: C1, C2, C2a, and C2b. While the previously reported engineered strain M. purpurea GK1101 can produce relatively high titers of C1a by blocking the genK pathway, a small amount of undesirable C2b is still being synthesized in cells. Gene genL (orf6255) is reported to be responsible for converting C1a to C2b and C2 to C1 in Micromonospora echinospora ATCC15835. In this work, we identify the genL that is also responsible for the same methylation in Micromonospora purpurea. Based on M. purpurea GK1101, we construct a new strain with genL inactivated and show that no C2b is produced in this strain. Therefore, we successfully engineer a strain of M. purpurea that solely produces gentamicin C1a. This strain can potentially be used in the industrial production of C1a for the synthesis of etimicin.
Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures
Authors: Stawny Maciej , Gostyńska Aleksandra , Dettlaff Katarzyna , Jelińska Anna , Kościelniak Marta , Ogrodowczyk Magdalena
Published: December 2019

Background: The administration of total parenteral nutrition (TPN) is a common procedure in intensive care units, where the concomitant use of other intravenous medication is frequently needed. One of the particularly dangerous complications for neurosurgical patients is meningitis, for which high doses of ampicillin (AMP) are used. In such cases, the addition of AMP to TPN admixtures would be a desirable procedure. Thus, the AMP determination method in TPN admixture was developed and validated. Methods: An isocratic HPLC analysis was performed on a LiChrospher C18 end-capped column (250 mm, 4.6 mm, 5 µm) with a C18 pre-column (LiChrospher 100, 4 mm, 5 µm). The flow rate was 1.0 mL min−1 and the detection wavelength was 230 nm. System suitability parameters, such as capacity factor, numbers of the theoretical plate, asymmetry factor, as well as validation parameters, including method precision, accuracy, linearity, selectivity, and robustness, were set up. Results: The method was shown to be linear, precise, accurate, specific, and robust, and it can be used for the quantitative analysis of AMP in TPN admixtures. Conclusions: The degradation of AMP in the TPN admixtures occurred according to first order kinetics. The degradation rate was high and dependent on the composition of the mixture and the storage conditions (t0.5 varied from 142.44 h to 300.45 h).
FAST-FUSION: An Improved Accuracy Omnidirectional Visual Odometry System with Sensor Fusion and GPU Optimization for Embedded Low Cost Hardware
Authors: Aguiar André , Santos Filipe , Sousa Armando Jorge , Santos Luís
Published: December 2019

The main task while developing a mobile robot is to achieve accurate and robust navigation in a given environment. To achieve such a goal, the ability of the robot to localize itself is crucial. In outdoor, namely agricultural environments, this task becomes a real challenge because odometry is not always usable and global navigation satellite systems (GNSS) signals are blocked or significantly degraded. To answer this challenge, this work presents a solution for outdoor localization based on an omnidirectional visual odometry technique fused with a gyroscope and a low cost planar light detection and ranging (LIDAR), that is optimized to run in a low cost graphical processing unit (GPU). This solution, named FAST-FUSION, proposes to the scientific community three core contributions. The first contribution is an extension to the state-of-the-art monocular visual odometry (Libviso2) to work with omnidirectional cameras and single axis gyro to increase the system accuracy. The second contribution, it is an algorithm that considers low cost LIDAR data to estimate the motion scale and solve the limitations of monocular visual odometer systems. Finally, we propose an heterogeneous computing optimization that considers a Raspberry Pi GPU to improve the visual odometry runtime performance in low cost platforms. To test and evaluate FAST-FUSION, we created three open-source datasets in an outdoor environment. Results shows that FAST-FUSION is acceptable to run in real-time in low cost hardware and that outperforms the original Libviso2 approach in terms of time performance and motion estimation accuracy.
Spatial Monitoring of Wafer Map Defect Data Based on 2D Wavelet Spectrum Analysis
Authors: Lim Munwon , Bae Suk Joo
Published: December 2019

Since machine vision systems (MVS) lead to a wide usage of monitoring systems for industrial applications, the research on the statistical process control (SPC) of image data has been promoted as an automated method for early detection and prevention of unusual conditions in manufacturing processes. In this paper, we propose a non-parametric SPC approach based on the 2D wavelet spectrum (WS-SPC) to extract the feature that contains the spatial and directional information of each subspace in an image. Using the 2D discrete wavelet transform and spectrum analysis, the representative statistic, the Hurst index, is calculated, and a single matrix space that consists of estimated statistics is reconstructed into a spatial control area for SPC. When a control limit is determined by the density of statistics, real-time monitoring based on WS-SPC is available for time releasing images. In the application, an analysis of wafer bin maps (WBMs) is conducted at a semiconductor company in Korea in order to evaluate the performance of the suggested approach. The results show that the proposed method is effective in terms of its fast computation speed and spectral monitoring.
Comparing the Physicochemical Properties of Upgraded Biomass Fuel by Torrefaction and the Ashless Technique
Authors: Sh Lkhagvadorj , Lee Byoung-Hwa , Lee Young-Joo , Jeon Chung-Hwan
Published: December 2019

The purpose of this study was to investigate and compare the influence of torrefaction and an ashless process on the physical and chemical properties of pitch pine sawdust (PSD) and kenaf as types of woody and herbaceous biomass. The physicochemical properties of the materials pretreated by the ashless process with torrefaction including proximate and ultimate analysis, hydrophobicity, grindability, morphology, and structure were analyzed. The results showed that when ashless Kenaf was torrefied, the high heating rate and atomic ratios of O/C and H/C increased. The tendency of the torrefied, ashless Kenaf to absorb water decreased, and it became more hydrophobic (approximately 0% for the uptake rate of moisture). In addition, the grindability of the torrefied, ashless Kenaf was substantially improved compared to that of pretreated PSD. Brunauer–Emmett–Teller and scanning electron microscopy results showed that when Kenaf was pretreated, particles easily lost their fibrous structure and cracked as the number of macropores decreased. These results indicate that the herbaceous biomass of Kenaf, when pretreated with both torrefaction and the ashless process, exhibits improved physicochemical properties compared to the woody PSD.
Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase
Authors: Blueggel Mike , van den Boom Johannes , Meyer Hemmo , Bayer Peter , Beuck Christine
Published: December 2019

AAA+ ATPase p97/valosin-containing protein (VCP)/Cdc48 is a key player in various cellular stress responses in which it unfolds ubiquitinated proteins to facilitate their degradation by the proteasome. P97 works in different cellular processes using alternative sets of cofactors and is implicated in multiple degenerative diseases. Ubiquitin regulatory X domain protein 1 (UBXD1) has been linked to pathogenesis and is unique amongst p97 cofactors because it interacts with both termini of p97. Its N-domain binds to the N-domain and N/D1 interface of p97 and regulates its ATPase activity. The PUB (peptide:N-glycanase and UBA or UBX-containing proteins) domain binds the p97 C-terminus, but how it controls p97 function is still unknown. Here we present the NMR structure of UBXD1-PUB together with binding studies, mutational analysis, and a model of UBXD1-PUB in complex with the p97 C-terminus. While the binding pocket is conserved among PUB domains, UBXD1-PUB features a unique loop and turn regions suggesting a role in coordinating interaction with downstream regulators and substrate processing
Hypertrophic Cardiomyopathy: An Overview of Genetics and Management
Authors: Teekakirikul Polakit , Zhu Wenjuan , Huang Helen C. , Fung Erik
Published: December 2019

Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle disorder with a diverse natural history, characterized by unexplained left ventricular hypertrophy (LVH), with histopathological hallmarks including myocyte enlargement, myocyte disarray and myocardial fibrosis. Although these features can cause significant cardiac symptoms, many young individuals with HCM are asymptomatic or mildly symptomatic. Sudden cardiac death (SCD) may occur as the initial clinical manifestation. Over the past few decades, HCM has been considered a disease of sarcomere, and typically as an autosomal dominant disease with variable expressivity and incomplete penetrance. Important insights into the genetic landscape of HCM have enhanced our understanding of the molecular pathogenesis, empowered gene-based diagnostic testing to identify at-risk individuals, and offered potential targets for the development of therapeutic agents. This article reviews the current knowledge on the clinical genetics and management of HCM.
Aldol Condensation of Cyclohexanone and Furfural in Fixed-Bed Reactor
Authors: Tišler Zdeněk , Vondrová Pavla , Hrachovcová Kateřina , Štěpánek Kamil , Velvarská Romana , Kocík Jaroslav , Svobodová Eliška
Published: December 2019

Aldol condensation reaction is usually catalysed using homogeneous catalysts. However, the heterogeneous catalysis offers interesting advantages and the possibility of cleaner biofuels production. Nowadays, one of the most used kinds of heterogeneous catalysts are hydrotalcites, which belong to a group of layered double hydroxides. This paper describes the aldol condensation of cyclohexanone (CH) and furfural (F) using Mg/Al mixed oxides and rehydrated mixed oxides in order to compare the catalyst activity after calcination and rehydration, as well as the possibility of its regeneration. The catalysts were synthesized by calcination and subsequent rehydration of the laboratory-prepared and commercial hydrotalcites, with Mg:Al molar ratio of 3:1. Their structural and chemical properties were determined by several analytical methods (inductively coupled plasma analysis (ICP), X-ray diffraction (XRD), diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), specific surface area (BET), thermogravimetric analysis (TGA), temperature programmed desorption (TPD)). F-CH aldol condensation was performed in a continuous fixed-bed reactor at 80 °C, CH:F = 5:1, WHSV 2 h−1. The rehydrated laboratory-prepared catalysts showed a 100% furfural conversion for more than 55 h, in contrast to the calcined ones (only 24 h). The yield of condensation products FCH and F2CH was up to 68% and 10%, respectively. Obtained results suggest that Mg/Al mixed oxides-based heterogeneous catalyst is suitable for use in the aldol condensation reaction of furfural and cyclohexanone in a fixed-bed reactor, which is an interesting alternative way to obtain biofuels from renewable sources.
Catalytic Dry Reforming and Cracking of Ethylene for Carbon Nanofilaments and Hydrogen Production Using a Catalyst Derived from a Mining Residue
Authors: Azara Abir , Benyoussef El-Hadi , Mohellebi Faroudja , Chamoumi Mostafa , Gitzhofer François , Abatzoglou Nicolas
Published: December 2019

In this study, iron-rich mining residue (UGSO) was used as a support to prepare a new Ni-based catalyst via a solid-state reaction protocol. Ni-UGSO with different Ni weight percentages wt.% (5, 10, and 13) were tested for C2H4 dry reforming (DR) and catalytic cracking (CC) after activation with H2. The reactions were conducted in a differential fixed-bed reactor at 550–750 °C and standard atmospheric pressure, using 0.5 g of catalyst. Pure gases were fed at a molar ratio of C2H4/CO2 = 3 for the DR reaction and C2H4/Ar = 3 for the CC reaction. The flow rate is defined by a GHSV = 4800 mLSTP/h.gcat. The catalyst performance is evaluated by calculating the C2H4 conversion as well as carbon and H2 yields. All fresh, activated, and spent catalysts, as well as deposited carbon, were characterized by Brunauer–Emmett–Teller (BET), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), transmission electron microscopy (TEM), temperature programmed reduction (TPR), and thermogravimetric analysis (TGA). The results so far show that the highest carbon and H2 yields are obtained with Ni-UGSO 13% at 750 °C for the CC reaction and at 650 °C for the DR reaction. The deposited carbon was found to be filamentous and of various sizes (i.e., diameters and lengths). The analyses of the results show that iron is responsible for the growth of carbon nanofilaments (CNF) and nickel is responsible for the split of C–C bonds. In terms of conversion and yield efficiencies, the performance of the catalytic formulations tested is proven at least equivalent to other Ni-based catalyst performances described by the literature.
Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity
Authors: Villedieu-Percheron Emmanuelle , Ferreira Véronique , Campos Joana Filomena , Destandau Emilie , Pichon Chantal , Berteina-Raboin Sabine
Published: December 2019

Extraction, isolation and characterization of Andrographis paniculata (A.p.) products were developed. Three natural diterpenes compounds were obtained and one was used for chemical modifications. Evaluation of their inhibition of TNFα induced NFκB transcriptional activity. A rapid analytical method for the determination and quantitation of three diterpenoid lactones (andrographolide 1, didehydroandrographolide 2, neoandrographiside 3) found in A. paniculata extracts was investigated. After some optimizations on column type and injection solvent, the separation was achieved in 9 min on a monolithic Chromolith Performance RP18e column (100 mm × 4.6 mm ID, 2 µm), with a gradient solvent system of water and methanol, UV detection at 220 nm and ELSD detection. The method was proved to be suitable for the quantitation of these three diterpenes in four different commercial Andrographis dietary supplements. The anti-inflammatory activities of a mixture of known composition have been evaluated showing differences in activity depending on the relative ratio of various diterpenes and also a possible synergic activity for some of them.
A Validated Method for Cholesterol Determination in Turkey Meat Products Using Relative Response Factors
Authors: Grasso Simona , Harrison Sabine M. , Monahan Frank J. , Brunton Nigel P.
Published: December 2019

The objective of this study was to develop a precise and accurate method to quantify cholesterol in turkey meat products using relative response factors, based on a modification of a previously published method for plant sterols determination. Validation was performed using neat solutions to determine linearity, precision, and accuracy. The method was linear in the concentration range considered (1–20 µg/mL, r2 ≥ 0.991). Precision and accuracy were within the acceptability guidelines of the U.S. Food and Drug Administration (FDA) for method validation (<20% relative standard deviation (RSD) at the lower limit of quantification (LLOQ) and <15% RSD for other standards). Turkey meat was spiked with cholesterol at two levels (low = 3 µg/mL and high = 18 µg/mL), either before or after saponification, to establish the recovery and matrix effects. Recovery ranged from 94% to 105%, with a mean value of 105% at the low spike level and 95% at the high spike level. No significant matrix effects were found (90% to 112% recovery). This method is reliable for the quantification of cholesterol in turkey meat products in the range 0.4–8 mg/g.
Chickpea Cultivar Selection to Produce Aquafaba with Superior Emulsion Properties
Authors: He Yue , Shim Youn Young , Mustafa Rana , Meda Venkatesh , Reaney Martin J.T.
Published: December 2019

Aquafaba (AQ), a viscous by-product solution produced during cooking chickpea or other legumes in water, is increasingly being used as an egg replacement due to its ability to form foams and emulsions. The objectives of our work were to select a chickpea cultivar that produces AQ with superior emulsion properties, and to investigate the impact of chickpea seed physicochemical properties and hydration kinetics on the properties of AQ-based emulsions. AQ from a Kabuli type chickpea cultivar (CDC Leader) had the greatest emulsion capacity (1.10 ± 0.04 m2/g) and stability (71.9 ± 0.8%). There were no correlations observed between AQ emulsion properties and chickpea seed proximate compositions. Meanwhile, AQ emulsion properties were negatively correlated with AQ yield and moisture content, indicating that AQ with higher dry-matter content displayed better emulsion properties. In conclusion, the emulsification properties of aquafaba are greatly influenced by the chickpea genotype, and AQ from the CDC Leader chickpea produced the most stable food oil emulsions.
Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors
Authors: Andrianova Nadezda V. , Buyan Marina I. , Zorova Ljubava D. , Pevzner Irina B. , Popkov Vasily A. , Babenko Valentina A. , Silachev Denis N. , Plotnikov Egor Y. , Zorov Dmitry B.
Published: December 2019

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal cells have a pronounced ability to proliferate after injury, which undermines that the kidney cells are able to regenerate under induced conditions. The majority of studies explain yielded regeneration either by the dedifferentiation of the mature tubular epithelium or by the presence of a resident pool of progenitor cells in the kidney tissue. Whether cells responsible for the regeneration of the kidney initially have progenitor properties or if they obtain a “progenitor phenotype” during dedifferentiation after an injury, still stays the open question. The major stumbling block in resolving the issue is the lack of specific methods for distinguishing between dedifferentiated cells and resident progenitor cells. Transgenic animals, single-cell transcriptomics, and other recent approaches could be powerful tools to solve this problem. This review examines the main mechanisms of kidney regeneration: dedifferentiation of epithelial cells and activation of progenitor cells with special attention to potential niches of kidney progenitor cells. We attempted to give a detailed description of the most controversial topics in this field and ways to resolve these issues.
Microbiota, Food, and Health
Authors: Laitinen Kirsi , Gueimonde Miguel
Published: December 2019

The effects of specific foods, such as products containing probiotics or prebiotics, on human health and the role of intestinal microbiota in this interaction have been a subject of scientific interest for several decades [...]
Elucidating the Role of K+ Channels during In Vitro Capacitation of Boar Spermatozoa: Do SLO1 Channels Play a Crucial Role?
Authors: Yeste Marc , Llavanera Marc , Pérez Guillermo , Scornik Fabiana , Puig-Parri Josep , Brugada Ramon , Bonet Sergi , Pinart Elisabeth
Published: December 2019

This study sought to identify and localize SLO1 channels in boar spermatozoa by immunoblotting and immunofluorescence, and to determine their physiological role during in vitro sperm capacitation. Sperm samples from 14 boars were incubated in a capacitation medium for 300 min in the presence of paxilline (PAX), a specific SLO1-channel blocker, added either at 0 min or after 240 min of incubation. Negative controls were incubated in capacitation medium, and positive controls in capacitation medium plus tetraethyl ammonium (TEA), a general K+-channel blocker, also added at 0 min or after 240 min of incubation. In all samples, acrosome exocytosis was triggered with progesterone after 240 min of incubation. Sperm motility and kinematics, integrity of plasma and acrosome membranes, membrane lipid disorder, intracellular calcium levels and acrosin activity were evaluated after 0, 60, 120, 180, 240, 250, 270 and 300 min of incubation. In boar spermatozoa, SLO1 channels were found to have 80 kDa and be localized in the anterior postacrosomal region and the mid and principal piece of the tail; their specific blockage through PAX resulted in altered calcium levels and acrosome exocytosis. As expected, TEA blocker impaired in vitro sperm capacitation, by altering sperm motility and kinematics and calcium levels. In conclusion, SLO1 channels are crucial for the acrosome exocytosis induced by progesterone in in vitro capacitated boar spermatozoa.
Thiazole- and Thiadiazole-Based Metal–Organic Frameworks and Coordination Polymers for Luminescent Applications
Authors: Mercuri Giorgio , Giambastiani Giuliano , Rossin Andrea
Published: December 2019

This mini-review focuses on the 2015–2019 literature survey of thiazole- and thiadiazole-containing Metal–Organic Frameworks (MOFs) and Coordination Polymers (CPs) exploited in the applicative field of luminescent sensing.
Impact of Positive Airway Pressure on International Restless Legs Syndrome Score in Sleep Disordered Breathing
Authors: Lakshmanan Seetha , Thompson Nicolas R. , Pascoe Maeve , Mehra Reena , Foldvary-Schaefer Nancy , Katzan Irene L. , Walia Harneet K.
Published: December 2019

Study Objective: Studies have shown increased prevalence of restless legs syndrome (RLS) in sleep disordered breathing (SDB), however limited data have focused on the impact of SDB therapy on RLS. We hypothesize that positive airway pressure (PAP) will improve the International Restless Legs Syndrome (IRLS) score among SDB patients compared to patients without PAP. Methods: Patients with AHI ≥ 5 who responded positively to a RLS qualifier question from January 2010 to May 2015 were included in this retrospective study. IRLS score was used to measure RLS symptom severity. Two-sample t-tests and one-way analysis of variance were used to compare changes in IRLS score and linear regression models were created to examine IRLS change with PAP use and PAP adherence (PAP usage ≥4 h nightly for ≥70% of nights), adjusting for potential confounders. Results: In 434 patients (51.9 ± 13.4years, 50.5% female, 77.6% Caucasian; 325 PAP, 109 control), IRLS scores improved from baseline to follow-up, with the PAP group achieving significant improvement after adjustment for covariates (difference in IRLS: −1.8 (CI −3.6,0.00), p = 0.050). In self-reported PAP adherent patients, IRLS improvement was greater than controls (−5.3 ± 7.4 vs. −2.7 ± 7.6 respectively, p = 0.045), and comparable to non-adherent patients (−5.3 ± 7.4 vs. −3.0 ± 7.0, p = 0.091). Conclusions: Among SDB patients with a positive RLS qualifier, those who used PAP therapy achieved significantly greater improvement in IRLS scores than patients who did not use PAP, with more significant changes in the PAP adherent group. This is the first large clinical study to examine these relationships, providing a basis for future prospective interventional trials and informing clinicians of expected improvement in IRLS score in PAP treated SDB populations.
The Incidence of Chronic Kidney Disease Three Years after Non-Severe Acute Kidney Injury in Critically Ill Patients: A Single-Center Cohort Study
Authors: Rubin Sébastien , Orieux Arthur , Clouzeau Benjamin , Rigothier Claire , Combe Christian , Gruson Didier , Boyer Alexandre
Published: December 2019

The risk of chronic kidney disease (CKD) following severe acute kidney injury (AKI) in critically ill patients is well documented, but not after less severe AKI. The main objective of this study was to evaluate the long-term incidence of CKD after non-severe AKI in critically ill patients. This prospective single-center observational three-years follow-up study was conducted in the medical intensive care unit in Bordeaux’s hospital (France). From 2013 to 2015, all patients with severe (kidney disease improving global outcomes (KDIGO) stage 3) and non-severe AKI (KDIGO stages 1, 2) were enrolled. Patients with prior eGFR < 90 mL/min/1.73 m2 were excluded. Primary outcome was the three-year incidence of CKD stages 3 to 5 in the non-severe AKI group. We enrolled 232 patients. Non-severe AKI was observed in 112 and severe AKI in 120. In the non-severe AKI group, 71 (63%) were male, age was 62 ± 16 years. The reason for admission was sepsis for 56/112 (50%). Sixty-two (55%) patients died and nine (8%) were lost to follow-up. At the end of the follow-up the incidence of CKD was 22% (9/41); Confidence Interval (CI) 95% (9.3–33.60)% in the non-severe AKI group, tending to be significantly lower than in the severe AKI group (44% (14/30); CI 95% (28.8–64.5)%; p = 0.052). The development of CKD three years after non-severe AKI, despite it being lower than after severe AKI, appears to be a frequent event highlighting the need for prolonged follow-up.