bluuebunny/crossref_metadata_2025 huggingface dataset:
The classical solvability for a one-dimensional nonlinear thermoelasticity system with the far field degeneracy
Authors: Hu Yanbo , Sugiyama Yuusuke
Published: June 2024

We study the local classical solvability of the Cauchy problem to the equations of one-dimensional nonlinear thermoelasticity. The governing model is a coupled system of a nonlinear hyperbolic equation for the displacement and a parabolic equation for the temperature of the elastic material. We allow the hyperbolic equation to degenerate at spacial infinity, which results that the coefficients of the coupled system are not uniformly bounded and then the previous methods for the strictly hyperbolic-parabolic coupled systems are invalid. We introduce a suitable weighted norm to establish the local existence and uniqueness of classical solutions by the contraction mapping principle. The existence time T of the solution is independent of the spatial variable.
Limitations of glycated albumin standardization when applied to the assessment of diabetes patients
Authors: Lenters-Westra Erna , Atkin Stephen L. , Kilpatrick Eric S. , Slingerland Robbert J. , Sato Asako , English Emma
Published: June 2024

Objectives

Glycated albumin (GA) has potential value in the management of people with diabetes; however, to draw meaningful conclusions between clinical studies it is important that the GA values are comparable. This study investigates the standardization of the Norudia Glycated Albumin and Lucica Glycated Albumin-L methods.

Methods

The manufacturer reported imprecision was verified by performing CLSI-EP15-A3 protocol using manufacturer produced controls. The Japanese Clinical Chemistry Reference Material (JCCRM)611-1 was measured 20 times to evaluate the accuracy of both methods. GA was also measured in 1,167 patient samples and results were compared between the methods in mmol/mol and %.

Results

Maximum CV for Lucica was ≤0.6 % and for Norudia ≤1.8 % for control material. Results in mmol/mol and % of the JCCRM611-1 were within the uncertainty of the assigned values for both methods. In patient samples the relative difference in mmol/mol between the two methods ranged from −10.4 % at a GA value of 183 mmol/mol to +8.7 % at a GA value of 538 mmol/mol. However, the relative difference expressed in percentage units ranged from of 0 % at a GA value of 9.9 % to +1.7 % at a GA value of 30 %.

Conclusions

The results in mmol/mol between the two methods for the patient samples were significantly different compared to the results in %. It is not clear why patient samples behave differently compared to JCCRM611-1 material. Valuable lessons can be learnt from comparing the standardization process of GA with that of HbA1c.
The Silicon Valley paradox: A qualitative interview study on the social, cultural, and ideological foundations of a global innovation center
Authors: Quandt Thorsten , Klapproth Johanna
Published: June 2024

Silicon Valley is both object of intense fascination and stark criticism. Academic observers have described it as a unique amalgamation of hippie culture, libertarian thinking, wild experimentation, but also scientific rigor, high-tech precision, and turbo-capitalism – a seemingly improbable, even paradoxical combination. Nevertheless, Silicon Valley continues to be an economic powerhouse and a global innovation hub. The current study explores its socio-cultural and ideological foundations through the lens of an insider perspective to find explanations for its stability and sustained success in light of conflicting components. Based on 15 interviews with Silicon Valley experts from start-ups, tech giants, and academic institutions, the study identifies several paradoxes on the level of ideology and environment, structure(s), and actors. These can be grouped into a binary, oppositional view, indeed describing the Silicon Valley paradox. However, alternative explanations are given, including the conceptualization as a non-dualist phenomenon.
Entering Into a Sonic Intra-Active Quantum Relation with Plant Life
Authors: España Keller Juliana
Published: June 2024

In the speculative research of plant bioacoustics, one enters into a sonic intra-active relation, by humans with non-human beings (plant life), activated through acoustic wave signals emitted by plants to create electronic patterns of sounds composed by humans and emitted by machines. Plants emit sound waves at relatively low frequencies of 50–120 Hz. Experimenting with patching and modulation by tracking these sonic lines of data can indeed lead to unique sonic experiences that tap into the universe’s musicology. It is fascinating how we can interact with sounds on such a deep level to create acoustic energy. We are and have always been attached to the universe in a relational processual way. We are all interconnected with plant life vibrating at different internal frequencies. This article focuses on a symbiotic relation between humans and plant life as an acoustic shimmering ecology – to communicate a posthuman, symbiotic understanding of vegetal matter as a morphological force that (re)shapes, (re)affirms our sonic intra-relations to the natural world. This proposition is molecular and metaphysical, as sound matter is of a qualitative multiplicity in the quantum field of listening. By acknowledging ontologically that cosmopolitics brings into relation different practices, practitioners, and the non-human (they assemble in a field of forces and intensities), I argue that there is no sovereign power under which all modes of existence can be organized, and there is no meta-language through which one can master the diversity of all discursive or material practices; but there are intra-relations in which one can get lost in a quantum field of sonic matter by moving into the cracks of the sensorium and the plant biosphere, which includes Indigenous voices. The alterity of plant life is daunting from an eco-feminist materialist position in that relationships are the default state of existence and sonic experiences uncover alternative or additional explanations in a (post)phenomenological world – which is embedded in the stuff of acoustics in the many ways humans hear the world. Thus, to communicate a posthuman, symbiotic understanding of vegetal matter necessitates understanding how sound matter intra-performs through a sonic language – where intra-relations with plant life have complex boundaries for humans. As a creative practitioner, how does one define the mutually beneficial engagement in plant communication with creative musical encounters? Entanglement is messy and a becoming with the universe as a philosophical sonic meditation and worlding. This entails expanding on plants as cosmogonic beings, world builders, and we, perhaps, are the by-products of the lives of our vegetal others.
Determination of molecular pathways and gene ontology of genes associated with Raynaud’s phenomenon
Authors: Öztan Gözde
Published: June 2024

Objectives

Raynaud’s phenomenon (RP) is a disease that causes discoloration of the fingers. The purpose of this study is to identify the molecular pathways in which genes related to RP illness are involved, as well as uncover the biological processes and molecular functions connected with those genes via the use of gene ontology (GO) analysis.

Methods

Genes associated with RP in the MalaCards Human Diseases database were detected. Twenty genes obtained from the MalaCards Human Diseases database were included in the study for gene ontology analysis via the STRING database. Accordingly, possible interactions between 20 genes were determined through STRING and network enrichment was performed.

Results

A significant enrichment by gene ontology enrichment analysis was detected in a subset of genes involved in biological processes including cellular response to luteinizing hormone stimulus, negative regulation of fibrinolysis, negative regulation of smooth muscle cell apoptotic process, plasminogen activation, cellular response to follicle-stimulating hormone stimulus. The assay for molecular function determined enrichment of a subset of genes in chemoattractant activity, growth factor activity, heparin binding, sulfur compound binding, growth factor receptor binding. Through the use of KEGG pathways, we were able to identify many molecular processes that contribute to RP, including the AGE-RAGE signaling pathway in diabetic complications, complement and coagulation cascades, fluid shear stress, atherosclerosis.

Conclusions

Some individuals may have a genetic predisposition to the onset of Raynaud’s phenomenon. Our data showed that it is associated with genes involved in vascular damage and fibrosis, especially in RP. Therefore, we can include RP disease in the group of vascular diseases.
Effect of Cross-Sectional Designs of Different Ni-Ti Files on Shaping Ability After Repeated Usage in Simulated Root Canals.
Authors:   Directorate of Health, Erbil, Iraq., Qaddori Fikrat Shawqi , Salman Raid Fahim
Published: June 2024

Background and Objective: The study aimed was to compare the effect of cross-sectional designs of five rotary systems (One Curve, 2Shape, K3-i File, E3 Azure, Neolix), on the shaping ability of the files in simulated resin blocks under controlled conditions with five repeated use. The shaping ability of the files includes the following variables: (1) Longitudinal sectional area difference, (2) Canal wall surface area difference, (3) Canal volume difference, (4) SMI (structure material index) difference, (5) Cross-sectional area difference. Methods: Five rotary file systems: (1) One Curve, (2) 2Shape, (3) K3-i File, (4) E3 Azure, (5) Neolix, were tested in simulated J-shaped root canal resin blocks with a 45˚ angle of curvature. 10 files from each system, each one of the 10 files were used to prepare 5 resin blocks, named R1-R2-R3-R4-R5. All the used files from the 5 systems had tip size 25 diameter, and taper (6%), and length (25 mm). The first 4 rotary systems were used with a fixed speed (350 rpm), and fixed torque (3 Ncm), except for the fifth system which was used with a speed of (500 rpm), and torque (4 Ncm), Following the manufactural recommendation of each system. All the 250 resin blocks were prepared for Glide Path with manual reamers size 10, and 15, with a fixed working length 16 mm, then all the 250 samples were prepared with a Proglider rotary file from Dentsply (size 16 taper 3%), then finally were prepared with Edge Files (USA), with size 20 and taper 6%, reaching to the step of master preparation with the selected files of the 5 systems. Using a customized device for preparation to ensure fixed vertical force and to exclude any lateral force, preparation was done with EDTA solution as irrigation, with a fixed no. of 4 strokes for the first 5 systems and 9 strokes for the Neolix, the time was controlled by using a Metronome, each stroke duration was 6 seconds. Results: In the first, second, third, and fourth variables a statistically non-significant difference (P > 0.05) was found between One curve and 2Shape, a statistically significant difference (P < 0.05) was found between One Curve, K3-i File, E3 Azure, and Neolix. About the fifth variable which is the Cross-sectional area difference: the study compared the difference between the cross-section area of the canal at the point D8, comparing the cross-section area before and after preparation using ANOVA test and Post hoc test, a statistically significant difference (P < 0.05) was found between the Neolix and (2shape, K3 i-File, and E3 Azure). Conclusion: The cross-sectional design of the endodontic rotary instrument had an obvious effect on the shaping ability of the system. Keywords: Cross-sectional design, Shaping ability, Nickle Titanium rotary files (One Curve, 2Shape, K3-i File, E3 Azure, Neolix).
The Effect of Propolis Irrigation as an Adjunctive to Scaling and Root Surface Debridement on Periodontal Health Status, Glycemic Control and Biochemical Markers in Subjects with Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial.
Authors:   Department of Periodontics, College of Dentistry, Hawler Medical University, Erbil, Iraq.
Published: June 2024

Background: Periodontitis is the inflammation of supporting tooth structures; it is one of the six complications of diabetes, Propolis a local delivery agent can be used as an adjunct to non-surgical periodontal therapy. Aim: To assess the effect of Propolis as adjunctive to scaling and root surface debridement for the treatment of periodontitis patients with type 2 diabetes. Methods: forty-five chronic periodontitis patients with poorly controlled type 2 diabetes (glycated hemoglobin 1 assay HbA1c≥8%) were recruited into group I; (n=15) scaling and root planing alone was performed, group II; (n=15) scaling and root planing+ chlorhexidine mouth wash twice a day for two weeks were prescribed, in the group III; scaling and root planing +Propolis irrigation was performed for two weeks, twice weekly. Clinical periodontal, haematological (fast blood sugar and glycated haemoglobin) and biochemical parameters (total antioxidant capacity and total oxidant status) were recorded at base line and three months of therapy. Results: The results indicated that there was a highly significant improvement of the clinical parameters in group I and II (p<0.001), in group I at baseline, the correlations between probing pocket depth and clinical attachment loss with total antioxidant capacity were significant and highly significant respectively, probing pocket depth and clinical attachment loss with total oxidant status were significant. While after 3 months of therapy, the correlations between bleeding on probing and gingival index with total antioxidant capacity were significant and highly significant respectively, plaque index and gingival index with total oxidant status were significant. Conclusion: Propolis irrigation could improve clinical periodontal parameters in chronic periodontitis patients with type 2 diabetes, with significant improvement of fast blood sugar and total oxidant status in group II and glycated haemoglobin in group III were exhibited. Keywords: Propolis, type 2 diabetes mellitus, total antioxidant capacity, total oxidant status, chronic periodontitis.
THE PERSPECTIVES OF SOCIAL WORK SUPERVISEES ON THE QUALITY OF SUPERVISION IN THE GIYANI REGION OF LIMPOPO PROVINCE, SOUTH AFRICA
Authors: Maluleke Tsunduka , Bhuda Gladys Bathabile
Published: June 2024

This article reports on a qualitative research study which was intended to explore the perspectives of social work supervisees on the quality of supervision in the Giyani region of Limpopo, South Africa. It was important to determine the quality of supervision rendered because social work supervision is intended to capacitate social workers with knowledge and skills and to support them, yet such supervision is fraught with challenges for decades. Purposive sampling was thus used to select study participants from whom data were collected by means of semi-structured interviews. The study findings revealed that the majority of the participants (10 of the 13) were not offered quality supervision by their supervisors. The participants attributed the poor supervision to the fact that their supervisors were delegated not appointed to supervise. The study thus recommends that all delegated social work supervisors in the Giyani region should be permanently appointed to their supervision positions. Keywords: quality supervision, social work, social work supervisee, social work supervisor, supervision
Arheološki nadzor u samostanu sv. Frane u Zadru
Authors: Jurković Pešić Filipa
Published: June 2024

U razdoblju od svibnja do rujna 2022. godine tijekom preuređenja i obnove zapadne zgrade Samostana sv. Frane u Zadru, Odjel za arheologiju provodio je arheološki nadzor nad svim zemljanim iskopima koji su se provodili u sklopu obnove. Zemljani radovi u sklopu obnove pretežito su bili vezani uz iskope temelja kako bi se mogli dokumentirati i ojačati. Širina iskopa iznosila je najčešće do 100 cm, a dubina je ovisila o dubini samih temelja. Iskopi unutar zapadnog dijela samostanskog kompleksa upućuju na to da su najveće dogradnje i promjene nastale u vrijeme baroka u 18. stoljeću. Tijekom iskopa unutar klaustra, očekivano se naišlo na novovjekovne grobnice s višestrukim pokopima i sloj dislociranih kostiju među njima.
Arheološko istraživanje na lokalitetu Jezera – Crikvina na sjevernom Velebitu
Authors: Glavaš Vedrana
Published: June 2024

Tijekom rujna 2022. godine nastavljena su arheološka istraživanja na lokalitetu Crikvina na predjelu Jezera (sjeverni Velebit). Istraživanje je nastavak probnih arheoloških istraživanja započetih 2019. godine unutar suhozidnog objekta koji je u usmenoj predaji poznat kao pastirska crkva posvećena sv. Anti.
Programa de acreditación Estado Verde de Chile y la educación ambiental: una evaluación desde la perspectiva de las personas funcionarias públicas
Authors: Rungruangsakorn Carlos , Ayala Camila , Bravo Alejandro , Díaz Darlyn , Cáceres María Paz , Moraga Catalina
Published: June 2024

[Introduction]: The Estado Verde accreditation program is an instrument created by the Chilean Ministry of the Environment so that Chilean public institutions, on a voluntary basis, can conduct environmental management in their facilities. Among the main purposes of the program, it seeks to encourage the advance of environmental habits in public officials through environmental education. [Objective]: To determine if the educational and communicational campaigns promoted by the program have generated changes in the environmental habits and behaviors of civil servants. [Methodology]: The combined method was used, and for this purpose a survey was designed, on a universe of 25 000 employees obtaining a sample of 270 cases, with a confidence level of 90 % and an error level of 5 %. In addition, 15 in-depth interviews were conducted. The results were analyzed separately and then a cross analysis was developed. [Results]: Officials recognize changes in habits favorable to environmental care in their institutions, although these are not generalized. [Conclusions]: While the Green State accreditation program does induce changes in habits and behaviors among public employees, it requires additional reinforcement in the promotion of its educational strategies and modifications in certain requirements to fully achieve its goal in non-formal environmental education. Furthermore, the findings may be useful for Latin American States to adopt pro-environmental actions in the administrative functioning of their public institutions..
EXTRACTION OF SULPHUR-CONTAINING AND POLYCYCLIC AROMATIC COMPOUNDS OF DIESEL FUEL WITH IMIDAZOLE-CONTAINING IONIC LIQUIDS
Authors: KOBOTAEVA N  S. , SAVINYKH YU  V. , SKOROKHODOVA T  S.
Published: June 2024

The extraction of sulphur-containing compounds of diesel fuel (DF) with ionic liquids (IL) based on imidazole with various substituents (butyl, octyl, nonyl, dodecyl, cetyl) in position 1 of the imidazole ring has been studied; the composition of sulphur-containing compounds and polycyclic aromatic hydrocarbons (PAH) has been determined by gas chromatography - mass spectrometry in the initial and purified diesel fuel. The optimal extraction conditions are determined: temperature 30-35 °C, extraction time 60 min, DF/IL ratio 1.66-2. The most effective extractant for the sulphur-containing compounds of DF is 1-nonyl-3-methylimidazolium bromide, which allows reducing the total sulphur content from 0.369 to 0.143 wt%. Results of the studies of group and individual composition of dibenzothiophene (DBT) and PAH derivatives show that the degree of extraction of DBT derivatives and tricyclic aromatic hydrocarbons is 66-72 %. Naphthalene and its homologues are extracted to a lesser extent - 37 %. Among DBT homologues, dimethyldibenzothiophene is extracted most completely.
Molecular identification of extreme resistance genes to PVY among breeding lines and potato varieties of Ukrainian origin
Authors: Hadzalo Ya. M. , Kyrychenko S. O. , Bondus R. O. , Kozub N. O.
Published: June 2024

Aim. Molecular identification of two genes responsible for extreme resistance (ER) to potato virus Y (PVY),
viz. Ryadg and Rychc. in potato lines and varieties bred in Ukraine. Methods. In total 78 potato samples (40 breed-
ing lines and 38 varieties) were studied. To identify the Ryadg and Rychc genes, the molecular markers RYSC3 and
Rу186, respectively, were used. The silica-based technique was used to isolate DNA from potato leaves or tubers.
Amplified products were analysed with agarose gel-electrophoresis. Results. Molecular markers were used to
evaluate 40 breeding lines produced by the Polissia Experimental Department of the Institute for Potato Research,
the NAAS, the harvest of 2022, and 38 cultivars, registered in the period of 1981–2015, from the collection of the
Ustymivka experimental station of the Institute of Plant Production n.a. V.Ya. Yuriev, the NAAS. Five varieties,
Oksamyt, Horlytsia, Lybid, Ivankivska rannia, and Ikar, and 19 lines contained the marker for Rychc. The gene Ryadg
marker was detected in one cultivar (Obriy) and eight breeding lines. Six lines carried both genes Ryadg and Rychc.
Field evaluation against the natural PVY infection background indicated false-positive results of the presence of
ER genes in Obriy and Lybid. The frequencies of the ER genes to PVY Ryadg and Rychc were considerably higher
in the group of breeding lines than in the sample of varieties, 47.5 and 10.5 % for Rychc, and 20 and 0 % for Ryadg,
respectively. Conclusions. Our study confirmed the possible presence of extreme resistance genes to PVY, Ryadg
and Rychc, in 4 Ukrainian potato varieties and 21 breeding lines. A higher frequency of carriers of the resistance
genes was present in the new breeding lines (52.5 %) than in the varieties already in production (10.5 %). The total
frequency of both genes was fairly similar to the one detected in the earlier study. If the lines and varieties where
the above-mentioned resistance genes were detected are truly resistant in the field and origin of these resistance
genes in the Ukrainian potato material has still to be investigated.
On the economics of co-opting in energy sector
Authors:   Institute of Industrial Economics of the NAS of Ukraine, Cherevatskyi Danylo
Published: June 2024

The purpose of the work is to formulate the main provisions of the co-opting economy and detail them using the case method in the field of energy. Elizabeth Watkins and David Stark from Columbia University (USA) put forward the concept of Möbius organizational forms. Unlike traditional forms in business, Möbius forms do not Make, Buy or Cooperate, they Co-opt assets that do not belong to them. In 2019, the author of this work proposed the term "paraphernalia", which reflects the essence of the theory, but the name is more suitable for the Global Informality Project online encyclopedia, in which it was published. The co-opting economics is a social science about the production, distribution, exchange and consumption of goods and services with non-violent, but non-cooperative appropriation of assets belonging to others to satisfy one's own needs. The original formula of the co-opting economy is: money-commodity-money with a dash and an additional commodity (good) received for free, which is produced with the help of assets belonging to other owners. Theoretical studies were carried out using the case method. The effect of the co-opting economy is demonstrated on the example of the Sukha Balka mine (Kryvyi Rih). The mine has shafts hoists. In the process of moving loads, hoist generate electricity that is recovered and fed back into the network. The author introduces the conditional category "Mechanics", whose asset is mine hoist, and the category "Energeticians", whose asset is power distribution networks. The additional energy resource received by the Mechanics flows through the network to the Energeticians and becomes their property. There is a co-optation of assets that do not belong to Energeticians, with the receipt of a product that they use to meet their own needs. Such a virtual power plant does not belong to any energy company, but helps it to overcome the shortage of electricity during times of maximum load. Here, too, energy companies adhere to the economy of co-optation, because the generating assets they use are not their property. By adopting legislative acts on the introduction of the active consumer category, the state indirectly contributes to the development of the co-optation economy.
Experimental determination of the solid phase density of thermal power plant ash
Authors:   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Bulat Anatolii , Shevchenko Нeorhii ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Cholyshkina Valentyna ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine, Kurilov Vladyslav ,   M.S. Poliakov Institute of Geotechnical Mechanics of the National Academy of Sciences of Ukraine
Published: June 2024

Recycling of ash and slag waste from thermal power plants is an important environmental and economic task. The widespread use of ash in construction is mainly hindered by the high content of unburned carbon. The fine granulometric composition of the ash makes most mechanical methods of recycling and flotation ineffective, and is the most effective, environmentally friendly, and cheapest method is hydraulic separation. It allows for the recovery of about 70% of construction raw materials, in which the carbon content is reduced to regulatory commercial values, from 20% in raw ash to 5–10%. A central element of hydraulic separation research is establishing the hydraulic characteristics of the fly ash, with a special focus on determining its actual density, considering that the ash includes more than 10 different mineral components that have also undergone high-temperature transformation. Theoretical determination of the solid phase density of a multi-component mixture does not yield a reliable result. This article examines methods for determining bulk, true, and actual density, experimental approaches to their measurement, and the impact of various factors on these parameters. Correct density determination underlies the calculation of hydraulic characteristics of ash suspensions, the speed of hydraulic flows, and the efficiency of extracting individual components by way of hydroclassification and hydroseparation. The purpose of the research is to refine the methodology and experimentally determine the density of the solid phase of fly ash in its natural state and ash classified by size -240+40 µm, -40+0 µm, using the sample of ash from Pridniprovska TPP. The results of this work are significant for engineering when creating new technologies, for hydraulic devices recycling ash aimed at minimizing environmental impact and optimizing the use of technogenic resources. It was found that the density of the solid phase of ash from the ash dump of Pridniprovska TPP varies from 1.783 g/cm³ to 2.3, averaging 2.0 g/cm³. Variations in density are related to the inhomogeneity of the chemical composition, the presence of closed cavities in the particles. Keywords: fly ash, ash and slag waste.
Plasminogen influence on the PAI-1 release by human platelets
Authors:   Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Yusova O. I. , Grinenko T. V. ,   Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Drobot’ko T. F. ,   Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Tykhomyrov A. O. ,   Department of Enzyme Chemistry and Biochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: June 2024

РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo. Besides, PAI-1 suppresses plasmin formation and affects cell migration through interaction with vitronectin. РАІ-1 is secreted from α-granules of platelets upon stimulation of cells by agonists. The aim of our study was to explore the effects of Glu- and Lys-forms of plasminogen on PAI-1 secretion by platelets and to evaluate the possible role of plasminogen in modulation of agonist-induced PAI-1 release. The secretion of PAI-1 by platelets was investigated by the Western blot analysis. It has been established that depending on the agonist, PAI-1 can be released from platelets in a free form, in a complex with a tissue plasminogen activator, as well as in the form of high-molecular complexes that contain a tissue activator and vitronectin molecules. The revealed induction of PAI-1 secretion under the action of Gly- and Lys-forms of plasminogen indicates their ability to activate intracellular signaling pathways that regulate the release of platelet α-granules. Our findings may be of importance for elucidating the pathogenetic mechanisms of many diseases associated with abnormally enhanced platelet function and PAI-1-related disorders. Keywords: Glu- and Lys-plasminogen, PAI-1, platelets, vitronectin, α-granules
Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration
Authors:   Department of Bioorganic and Biological Chemistry, Poltava State Medical University, Poltava, Ukraine, Mykytenko A. , Akimov O. ,   Department of Pathophysiology, Poltava State Medical University, Poltava, Ukraine;, Yeroshenko G. ,   Department of Medical Biology, Poltava State Medical University, Poltava, Ukraine;, Neporada K. ,   Department of Bioorganic and Biological Chemistry, Poltava State Medical University, Poltava, Ukraine;
Published: June 2024

Modulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promi­sing option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK activity. The aim of this work was to estimate the effect of phenformin as AMPK activator on the development of oxidative-nitrosative stress in the liver of rats under conditions of long-term ethanol administration. The experiments were performed on 24 male Wistar rats, divided into 4 groups: control; animals, which received phenformin hydrochloride orally at a dose of 10 mg/kg daily for 63 days; animals with a forced intermittent alcoholization for 5 days by intraperitoneal administration of 16.5% ethanol solution in 5% glucose at the rate of 4 ml/kg b.w. and subsequent transfer to 10% ethanol as the only source of drinking; animals with chronic alcohol hepatitis simulation and phenformin administration. Superoxide dismutase, catalase, NO synthase isoforms activity, superoxide anion radical production, concentration of malonic dialdehyde, peroxynitrite, nitrites, nitrosothiols concentration and oxidative modification of proteins (OMP) were estimated in liver homogenates. The increased production of oxygen and nitrogen active forms and OMP intensification in the liver of rats under long-term administration of ethanol was detected. Phenformin introduction under long-term ethanol administration was shown to limit the excess peroxynitrite formation and to prevent oxidative damage to rat liver proteins. Keywords: AMP-activated protein kinase., chronic alcoholic hepatitis, liver, oxidative and nitrosative stress, phenformin
Mulheres, novas direitas, WhatsApp e reinvenção da relação casa-rua
Authors: Pavesi Patricia , Valentim Julio
Published: June 2024

Neste artigo procuramos compreender quais disposições e capacidades têm permitido a intensificação, na última década, do engajamento político de mulheres nas novas direitas. Nossa hipótese interpretativa é de que a ampliação do envolvimento de mulheres conservadoras com questões políticas se dá e é favorecida por uma complexa articulação entre políticas da identidade, economias de afeto e emoções, público-privado e tecnologias digitais de conexão. Propomos a discussão de cunho interpretativo e especulativo, inspirada por elementos empíricos produzidos em pesquisa etnográfica digital longitudinal por meio da qual temos rastreado traços digitais de mulheres conservadoras dos segmentos médios da Região Metropolitana da Grande Vitória (ES, Brasil). Adotamos uma abordagem relacional e construcionista, considerando elementos teórico-metodológicos da Teoria ator-rede, dos Estudos dos afetos e emoções, e da leitura da relação casa-rua proposta por Roberto DaMatta.
Expresión genética en Longissimus dorsi e hígado en dos etapas del crecimiento en cerdos
Authors: Lemus-Flores Clemente , Bugarín-Prado Job Oswaldo , Lemus-Avalos Gilberto , Loeza-Concha Henry
Published: June 2024

Introducción. La expresión genética varía en relación con la etapa fisiológica del cerdo y es diferente en músculo e hígado. Objetivo. Identificar los genes con expresión genética diferencial en los procesos biológicos del cerdo en los tejidos Longisimus dorsi e hígado, por medio del análisis de transcriptoma, durante la etapa de crecimiento (55 ± 1,05 kg) y la engorda final (101 ± 7,8 kg). Materiales y métodos. En la Unidad Académica de Agricultura de la Universidad Autónoma de Nayarit, México, durante el verano del 2019. Se consideraron 12 muestras totales, tres de músculo Longissimus dorsi y tres de hígado por etapa para la extracción de RNA y la secuenciación. Con el método DESeq2 se obtuvo diferencialmente la expresión génica de los Log2FC para Grupo Crecimiento vs Engorda Final del Longissimus dorsi e Higado y se identificó la función biológica de los genes con expresión genética diferencial. Resultados. En hígado se identificaron la mayor cantidad de genes con DEG y en el cromosoma 6 para Longissimus dorsi e higado. En Longissimus dorsi del Grupo crecimiento se expresaron los genes FUT1, SESN2 y FGF21 asociados al crecimiento, tambien se identificaron genes sin expresión como NR4A3, PDK4, PER1 y PTPRO los cuales estan involucrados en procesos del sistema inmune y ritmo circadiano. En hígado del Grupo crecimiento se expresaron los genes IHH y MYL7 y sin expresión MFSD2A, LIPG, THBS1, TGFB2, LTF y APOA4 como los más relacionados en procesos biológicos. Conclusiones. En Longissimus dorsi del grupo crecimiento los genes se relacionaron con el crecimiento y en engorda final con inmunidad, crecimiento y calidad de la carne. En hígado del grupo crecimiento los genes fueron relacionados con el crecimiento y en el grupo engorda final con inmunidad, crecimiento¸ metabolismo de nutrientes y lípidos, lipoproteínas y detoxificación.
Impact evaluation combining ability of tomato hybrids and lines for production and fruit quality traits
Authors: Essa Bassim Almass , Alwan Othman Khalid
Published: June 2024

Introduction. The selection of pure lines followed by crosses to create superior hybrids is one of the oldest strategies in crop breeding. Combining ability studies provide reliable information for selection of parents for hybrid combination by revealing the nature and magnitude of gene actions involved in expression of quantitative traits. Objective. To estimate the General and Specific Combining Ability (GCA and SCA) values for yield in cherry tomatoes and select F1 hybrids combining high yield and fruit quality traits. Materials and methods. The half-diallel design, following method 2 of Griffing was used to define the best breeding method. Five lines were crossed to produce 10 hybrid combinations using a half diallel design involving the parents. Crosses and evaluations were conducted in a greenhouse in the Experimental Station at the University of Diyala, Baqubah, Iraq, in the winter of 2022-2023. Results. Based on GCA effects, lines 'LA353', 'LA3899' and 'IQ2' could be potential donor parents in breeding. Based on average performance, heterosis manifested and SCA effects, crosses IQ2×LA4013, LA3899×LA353 and IQ2×LA3899 were best in respect to yield and fruit quality. Conclusion. The general and specific combining ability values for the majority of the traits supported the material's great variety. The magnitude of heterosis was improved compared to parental lines. The high-yielding parent lines 'LA3899' and 'IQ2' could be used for breeding cherry tomatoes under greenhouse conditions.
Two Old Uighur Vajracchedikā Sūtra Fragments from the National Library of China
Authors: Mirkamal Aydar
Published: June 2024

There are more than 10 block-printed and hand-copied versions of the Vajracchedikā Sūtra (The Diamond Sūtra) in Old Uighur preserved in Berlin, Paris and St. Petersburg. Recently, two block-printed fragments of Vajracchedikā Sūtra in Old Uighur, which are of the same origin as those in Berlin, were found in the National Library of China. Based on a comparative study, these items are believed to be translated from a Sanskrit version while referencing the Chinese translation by Dharmagupta. This paper presents a textual examination of the two Old Uighur Vajracchedikā Sūtra fragments.
Almonds Along the Silk Road
Authors: Albala Ken
Published: June 2024

This is a story of almonds and the passage of ideas eastward along the various routes that have come to be known as the Silk Road. While we normally think of exotic goods travelling westward, there was also a significant trade in the other direction, to China and south to India. Both the almond and ideas about how to use them made this journey. For example, a Chinese pharmacist will explain that among various properties of almonds, they suppress coughs and are useful for treating lung ailments. This is the same advice offered by Greek physician Galen of Pergamum nearly two millennia ago. A practioner of Ayurvedic medicine in India would suggest that almonds are fattening and serve as an aphrodisiac, but can be difficult to digest, again echoing ancient Greek medical ideas. These similarities are no coincidence. Despite the very different structure of these three medical systems, almonds were employed in similar ways in each. How this confluence of ideas might have taken place and the passage of almond uses eastward along the Silk Road is the topic of this article.
Learning French in a Late Thirteenth-Century English Bakehouse
Authors: Sayers William
Published: June 2024

This essay studies the the vocabulary of milling and baking found in the Anglo-Norman didactic treatise/ poem by Walter of Bibbesworth , an educational text for gentry families seeking instruction in the French language which came equipped with English glosses.
The Great Fig Hunt, Part I
Authors: Bland Alastair
Published: June 2024

A memoir of foraging for wild figs in California's Central Valley.
Florence White’s Good Food Register, 1935
Authors: Jaine Tom
Published: June 2024

A reprint of a small handbook to English provincial food compiled by Florence White, organized by country and identifying local specialties.
Students’ Expectations from Technology in Mathematical Tasks: Mathematical Relationships between Objects, Instrumental Genesis and Emergent Goals
Authors: Laina Vasiliki , Monaghan John
Published: June 2024

This paper explores a phenomenon that almost every mathematics teacher, who encourages her/his students to engage in rich mathematical tasks with digital technological tools, has experienced: the students say “let’s make it do this …” but ‘this’
is not a direct construction with the digital tool and the students get stuck (at least for a while). The ‘this’ varies with the task and the problem, what they get stuck on, varies with the software.
Changes in Pre-Service Teachers’ Algebraic Misconceptions by Using Computer-Assisted Instruction
Authors: Lin Cheng-Yao , Ko Yi-Yin , Kuo Yu-Chun
Published: June 2024

In order to carry out current reforms regarding algebra and technology in elementary school mathematics successfully, pre-service elementary mathematics teachers must be equipped with adequate understandings of algebraic concepts and self-confidence in using computers for their future
teaching. This paper examines the differences in preservice teachers’ misconceptions of algebra and their attitudes towards using computers in teaching mathematics between computer-assisted instruction and lecture instruction. The results of the study suggest that pre-service teachers
in both instructions have similar algebraic misconceptions and attitudes about teaching mathematics with computers. Even though there was no significant difference in algebraic misconceptions and beliefs about integrating computers into teaching mathematics between the participants in computer-assisted
instruction and lecturebased instruction, both instructions were effective to increase pre-service teachers’ knowledge of parentheses usage, symbolism, and equality and attitudes of using computer in teaching mathematics in terms of confident and liking. It is recommended that more attention
should be paid to teaching and learning algebra with computer-supported instruction in mathematics teacher education programs so that pre-service teachers gain experience in integrating technology into classrooms.
Designing Spatial Visualisation Tasks for Middle School Students with a 3D Modelling Software: An Instrumental Approach
Authors: Turgut Melih , Uygan Candaş
Published: June 2024

In this work, certain task designs to enhance middle school students’ spatial visualisation ability, in the context of an instrumental approach, have been developed. 3D modelling software, SketchUp®, was used. In the design process, software tools were focused on and, thereafter,
the aim was to interpret the instrumental genesis and spatial reasoning processes of two students on the use of the software tools. In the application of the tasks, it was observed that the students were easily familiar with certain tools; however, they were not good at some and needed instrumental
reinforcement. Additionally, the student whose spatial ability performance was better than the other could easily accomplish manipulation of the tools. In light of the obtained results, certain recommendations are made.
Prospective Mathematics Teachers’ Interactions with CAS-Based Textbook Elements
Authors: Davis Jon D.
Published: June 2024

This study investigated how a group of 10 prospective secondary mathematics teachers (PST) read, evaluated, and adapted a textbook lesson involving the symbolic manipulation capabilities of computer algebra systems (CASS). PST read the entire lesson and tended to focus on the organizing
question at the beginning of the student lesson and the CAS-S sections of the lesson. PST frequently evaluated the lesson with respect to the teacher and whether lesson elements would promote student understanding. Only one PST evaluated the lesson with respect to the student and how the student
might interpret lesson elements. There were five categories of curricular adaptations exhibited by PST: following, additive, mix, reductive, and adaptive. In general, the adaptations made to the lesson by PST were productive. These productive adaptations included asking students to make predictions
before using CAS-S and understanding the hidden procedures used by the technology.
De Alzira Soriano a Tainá de Paula: as eleições de 2020 sob uma perspectiva interseccional
Authors: Silva Mayra Goulart da , Homem Giulia Gouveia Siqueira Pinto
Published: June 2024

Resumo: Neste artigo, analisamos as eleições municipais de 2020 e as alterações no código eleitoral propostas em 2021, evidenciando progressos, retrocessos e empecilhos impostos às mulheres na política. Sob a hipótese de que os dados eleitorais do estado do Rio de Janeiro indicam um descompasso entre representação descritiva e substantiva de mulheres, utilizamos ferramentas metodológicas quantitativas e qualitativas para escrutiná-los. Buscamos lançar luz sobre as estruturas de opressões que mantêm as mulheres em situação subalterna no campo político, mobilizando o conceito de interseccionalidade para tanto. Assim, propomos uma leitura interseccional da representação de mulheres no Brasil, seguida pelo exame dos dados eleitorais de 2020 e, por fim, uma análise da disputa pelo ideal da mulher, exemplificada por meio das performances antagônicas de duas vereadoras eleitas no estado.
Cotidiano e a experiência urbana gay: afeminação como categoria analítica
Authors: Belarmino Victor Hugo , Dimenstein Magda , Leite Jáder Ferreira
Published: June 2024

Resumo: O tema da experiência urbana tem atraído o interesse crescente da comunidade científica, uma vez que a cidade é uma arena constantemente disputada, produto/produtora de subjetividades conflitantes. Neste artigo, a partir da experiência urbana gay afeminada, nos propomos a descrever as relações entre sexualidade/gênero e a cidade na produção e intensificação de processos de vulnerabilização psicossocial. Para tanto, aplicou-se um questionário remoto junto a 240 sujeitos, e foram realizadas 8 (oito) entrevistas individuais com homens gays autodeclarados afeminados. O espaço urbano destacou-se como um ambiente heteronormativo e violento às performances afeminadas. Na pandemia, as relações de opressão nas famílias se intensificaram para gays afeminados, confirmando que afeminação funciona como vetor de vulnerabilização psicossocial, um marcador social que imprime particularidades às vivências subjetivas e à sua experiência urbana, marcadas pelo medo e sofrimento.
Movimento feminista negro, ação coletiva e incidência em políticas públicas
Authors: Silva Mônica de Cássia Costa , Bronzo Carla , Brasil Flávia de Paula Duque
Published: June 2024

Resumo: O artigo tem por objetivo analisar a atuação do movimento feminista negro de Belo Horizonte, abordando seus repertórios de ação coletiva e de interação com o governo local e sua influência nas políticas públicas, a partir da perspectiva de seis ativistas. Trata-se de uma pesquisa qualitativa e exploratória cuja metodologia contemplou, além da revisão de literatura, levantamentos documentais, entrevistas em profundidade e análise de conteúdo. Foram mapeados os seguintes repertórios de ação coletiva: a) protestos e ação direta, b) participação institucionalizada em conselhos, conferências e orçamento participativo, c) ocupação de cargos na burocracia por ativistas e d) ocupação política, por meio de cargo eletivo de vereadora. A partir desses repertórios, o movimento feminista negro tem incidido nas políticas municipais, na perspectiva interseccional.
Bioética e inteligência artificial: panorama atual da literatura
Authors: Naves Érica Antunes
Published: June 2024

Resumo O termo inteligência artificial refere-se à realização, por dispositivos computacionais, de processos intelectuais característicos dos seres humanos, como raciocinar, descobrir significados, generalizar ou aprender com experiências. A atuação da inteligência artificial ocorre quando programas computacionais realizam ações para as quais não foram explicitamente programados. Apesar de o conceito ser bem definido, o desempenho dessa tecnologia é muito complexo, de modo que a bioética encontra diversos conflitos e questões relacionadas a ela, muitas vezes esclarecidas apenas no momento em que surgem. Embora regulamentações tenham sido instituídas ao longo do desenvolvimento da área, ela constantemente passa por adaptações, o que justifica novos estudos sobre o tema.