bluuebunny/crossref_metadata_2025 huggingface dataset:
Khortytsia Island is a Place Of Memory
Authors: Sarychev Viacheslav
Published: December 2023

In the article, using the example of Khortytska Sich, the evolution of views on the question of Sich genesis is considered in the context of the prevailing ideological conditions in different periods. The basis of research approaches is the theory of the place of memory of the French historian Pierre Nore, as well as the conclusions of the American philosopher Thomas Kuhn about the variability of scientific paradigms due to scientific revolutions and the impossibility of resolving their conflict with the help of evidence. At the everyday level of public consciousness, the concept of 'Khortytska Sich' was formed from the first half to the middle of the 17th century. It entered the scientific field in the second half of the 18th century. together with other centers of the Zaporizhzhya Cossacks in the lower Dnieper. However, Khortytska Sich did not fit into the system of official scientific views. The justification of the empire's 'rights' to the so-called Western Russia (Lithuanian, Belarusian and Western Ukrainian lands) required consideration of the Zaporizhzhya Cossacks as a pro-Moscow and anti-Polish force. Emphasis was placed on the era of wars against the Polish-Lithuanian Commonwealth, which since the end of the 16th century. led by the Zaporozhians. Cossack centers that arose before this period did not fall under the sich status. As a result, in the 19th century a tradition arose, the echo of which exists in modern Ukrainian historiography, to call Khortytsia not the place of Sich, but 'the place of gathering', 'protosich', etc. For the same reasons, Khortytska Sich did not fit into the class model of social development. In this way, the history of Sich found itself in the context of Russian history, and the issues of the activities of the Ukrainian people in the development of the southern territories and the creation of centers of self-government back in the days of the Grand Duchy of Lithuania receded into the background. Only with the restoration of Ukrainian independence in 1991 did the conditions for understanding the phenomenon of Khortytska Sich emerge. The new scientific paradigm allows us to consider the Ukrainian-centric models of the first Sich, its role in the development of southern lands, resistance to Ottoman-Tatar aggression, and the formation of the Cossack state. This actualizes the direction of further research into the historical authenticity of Khortytska Sich as the basis of the notion of a place of memory of the Ukrainian people.
Production of Iron Weapons for Regiments and Hundreds of the Zaporizhzhian Host on the Land of Drevlians (17th–18th Century)
Authors: Trachuk Oleksii
Published: December 2023

The article attempts to combine the research on iron production based on archival materials from the complex expedition of 1932 under the leadership of Oleksandr Ohloblin with the ways of providing weapons to hundreds and regiments of the Zaporizhzhian Host in the Land of Drevlians.The Ukrainian Cossack Hetmanate state of the 17th – 18th centuries, which was built on the ancient Ukrainian traditions of the tribal system, had its own administrative division into hundreds and regiments. The regiment and the hundred acted simultaneously as a military unit, a territorial unit, and a financial and judicial district. At the same time, the Zaporizhzhian Host had military and state-political autonomy, first as part of the Polish-Lithuanian Commonwealth (from the Treaty of Zboriv in 1649 to the Pereiaslav Agreement in 1654), and then as part of the Moscow state (realm and empire) from January 1654 (the Pereiaslav Agreement) and to the liquidation of the hundred-regiment administration of Left Bank Ukraine in September 1781 and the implementation of the division of this territory into governorships (provinces) in January 1782.In this study, we tried to identify ores that could provide the Cossacks' hundreds and regiments with weapons and other products during the Liberation War of the Ukrainian people led by Bohdan Khmelnytskyi.The issue of restoring the main industries in the land of Drevlians after the revolution of 1917–1918 arose during the reconstruction of Soviet Ukraine. At the beginning of 1922, the Volyn Miners Union proposed the revival of the iron and steel industry. In Soviet times, this was not done, but during the days of independence, the old branches of the Polissia industry on the territory of the Right Bank Polissia could be strengthened with the prospect of their further powerful development.
СТРАТЕГІЇ УПРАВЛІННЯ КОМПАНІЯМИ В УМОВАХ РОЗВИТКУ ТА ЦИФРОВОЇ АДАПТАЦІЇ З ШІ
Authors: Рижикова Наталія , Мандич Олександра , Микитась Аркадій , Гіржева Ольга
Published: December 2023

In today's rapidly evolving business landscape, marked by technological advancements and intensified market competition, companies are compelled to enhance their management strategies. This article delves into the imperative integration of digital techno
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ СУЧАСНОЇ ЖІНКИ-КЕРІВНИКА
Authors: Бедан Вікторія
Published: December 2023

The article presents the results of the diagnosis of the individual and psychological characteristics of a female manager, which determine the effectiveness of managerial activities. Theoretical and empirical studies on this topic are considered. A certai
Investigation of the Change in the Features of Turkish Items in the High School Entrance System 2018-2022
Authors: SAYIN Ayfer , MELANLIOĞLU Deniz
Published: December 2023

aim of this study is to examine in detail the structural features of the Turkish items in the High School Entrance System (LGS), which was first implemented in 2018, and to determine the changes in these features over the years. In this descriptive survey study, the changes in test difficulty, discrimination, and internal consistency of a total of 100 Turkish items in the LGS administered in 2018-2022 were examined first. Then, the textual (sentence, word, and syllable length; readability), contextual (visuality, meaning of the item stem, common stem) and purpose features (content domain, text type) of the items were determined and the changes in these features over the years were examined. As a result of the study, it was determined that the test difficulty of the LGS Turkish test decreased over the years; in other words, the items became more difficult over time. Although there was no general change in the test discrimination of the test, it was determined that there was a general decrease in the test discrimination of the test. In the study, it was also determined that the item lengths varied over the years and the average length of the test increased over the years. The texts in the items were mostly composed of informative texts; poetry and narrative texts were not included in the items in some years.
Examining effects of managerial and institutional ownerships on the market value of corporate spinoffs
Authors: Ozbek O. Volkan
Published: December 2023

Corporate spinoffs are tax-free transactions between the parent firm (a.k.a. divesting firm) and its newly created, independent spun-off subsidiary (a.k.a. child firm) to increase value for both sides’ shareholders. As critical governance mechanisms, in this study we examine the effects of institutional and managerial ownerships on the market value of spun-off subsidiaries based on the corporate governance literature and behavioral agency perspective. In our sample, we have 144 completed U.S. spinoffs within a 14-year of time span, which are drawn from the SDC Platinum. According to our empirical analysis, we have found that both ownership structures have significant negative effects on the change in market value of the child firm. In addition, we have examined the interaction effect of both ownerships, which results in another significant effect in the opposite direction. Thus, this study reveals the critical importance of institutional and managerial ownerships for the market success of spun-off subsidiaries.
Plan de Ordenamiento y Desarrollo Territorial de la Ciudad de Formosa POT FOR 2040
Authors: Barreto Miguel Ángel , Benítez María Andrea , Abildgaard Evelyn Roxana
Published: December 2023

El Plan de Desarrollo y Ordenamiento Territorial del Municipio de Formosa, POT FOR 2040 fue llevado adelante mediante un Acuerdo de Trabajo entre la Facultad de Arquitectura y Urbanismo y la Municipalidad de la Ciudad de Formosa. El objetivo principal de este Acuerdo fue dotar a la Municipalidad de una herramienta de gestión imprescindible para lograr el desarrollo justo, sostenible y equilibrado del territorio municipal, con un horizonte temporal al año 2040. El Plan fue elaborado por un Equipo Técnico de la Facultad que contó con el aporte de un Equipo Técnico Municipal. La propuesta del Plan se expresa en siete Líneas Estratégicas y 37 Ideas-proyectos, y contempla, además, una propuesta para su implementación y posibles instrumentos de gestión. Este artículo contiene una síntesis del Informe Final y del Libro II del Plan presentado a la Municipalidad de la Ciudad de Formosa.
Análisis del proyecto de ley de ordenamiento territorial de la provincia del Chaco (Argentina). Su articulación con el marco normativo e institucional vigente
Authors: Romagnoli Venettia , Fogar Sandra R. , Fernández María E.
Published: December 2023

Este artículo entiende la política de ordenamiento territorial como un sistema dinámico compuesto por tres elementos estructurales que se encuentran interrelacionados e interdefinidos: el marco normativo, los planes de ordenamiento territorial con sus instrumentos operativos y el modelo de gestión que permite llevarlos a cabo en el territorio. Desde este posicionamiento, que asume un enfoque epistemológico crítico, el marco legal de la política de ordenamiento ambiental del territorio se convierte en objeto de estudio ineludible para el sistema de ordenamiento en Argentina y, en particular, en el Chaco. Ante la inminente aprobación del Proyecto de Ley OT de la Provincia del Chaco, se propone analizar este nuevo instrumento que se sumaría al repertorio de normas actualmente vigentes.
Hidrantes contra incendio: Nada mejor que el agua para apagar el fuego
Authors: Benedetti Rubén
Published: December 2023

Se presenta la evolución de las operaciones contra incendio desde las primeras brigadas romanas hasta la creación de los cuerpos de bomberos, la evolución de los recursos para la provisión de agua hasta la invención de los hidrantes y cómo la disponibilidad de un suministro permanente da sentido a la operación de autobombas y otro equipamiento moderno. Se analiza someramente la normativa de la NFPA y los casos de ciudades europeas. En contraste se presenta el caso de la ciudad de Rosario y como la precariedad resultante obliga a operaciones de extinción asistidas por cubas duplicando el esfuerzo de los cuerpos de bomberos.
Formación docente y enseñanza de lengua qom: la construcción de espacios de recuperación de la lengua junto a futuras/os profesoras/os interculturales bilingües en Chaco
Authors: Romero Massobrio Lucía
Published: December 2023

El presente artículo busca caracterizar el proceso de recuperación de la lengua qom que protagonizan docentes y estudiantes del profesorado intercultural bilingüe de Chaco, Argentina. Me propongo explorar las políticas del lenguaje relativas a la lengua qom que tienen como destinatarios a las y los recuperantes. Enmarcada en el abordaje de políticas del lenguaje de perspectiva crítica, esta investigación entiende a las y los docentes como agentes clave en la creación y promoción de políticas del lenguaje que impulsan la recuperación de la lengua qom. Para ello, y desde una perspectiva etnográfica, me enfoco en iniciativas de docentes de carreras de formación de profesorado intercultural bilingüe en Chaco. Específicamente, retomo dos casos de formación de docentes recuperantes en los que estas agencias construyen y organizan espacios de enseñanza de la lengua comunitaria.
En suma, me propongo avanzar en la caracterización de estos procesos de recuperación y de sus vínculos con la formación de docentes que asumirán el rol de promover la recuperación que iniciaron en el nivel superior.
Reflexões sobre o estudo de línguas indígenas na formação de docentes indígenas na Universidade Federal de Goiás (UFG/Goiás/Brasil)
Authors: Veloso Borges Mônica
Published: December 2023

Neste artigo abordo minha experiência como professora de línguas indígenas no Curso de Licenciatura em Educação Intercultural da Universidade Federal de Goiás – Brasil (UFG), desde 2007, ano em que se iniciaram as aulas. Primeiramente, para contextualizar, apresento esse Curso, que tem por meta a formação de professores/as pesquisadores/as para atuarem em suas aldeias. Apresento as aulas que ministro, seus objetivos e metodologias, nos Temas Contextuais “Línguas Indígenas e o Português Brasileiro 1”, “Línguas Indígenas e o Português Brasileiro 2” e “Léxico: usos e suas funções sociais”, e nos Estudos Complementares “Línguas Indígenas”, que envolvem aspectos fonéticos, fonológicos, morfossintáticos, lexicais e sociolinguísticos, referentes às trinta línguas faladas pelos/as alunos/as. O texto mostra a relevância de se abordar o ensino de línguas indígenas em consonância com os aspectos sociais e culturais dos/as alunos/as.
The effect of modification with nanocompositions on the structure and properties of foundry silumins
Authors: Davydiuk Anzhela , Kalinina Natalia , Polizhko Serhiy
Published: December 2023

Abstract. Problem. The difficulty of solving the problem lies not only in the improved quality of casting alloys, but also in the development of recommendations for achieving stability of the chemical composition, refining the structure, and increasing the mechanical and technological properties of castings. Goal. The goal of the work is to achieve a stable dispersed structure and increase the complex of mechanical properties of foundry silumins. Methodology. Based on the Al – Si influence diagram, the choice of cast aluminum alloys for modification with nanocompositions is substantiated. The technology of modification with nanodisperse compositions consisted in introducing powders of the complex nanomodifier Mg2Si+SiС into the aluminum melt. A mixture of Mg2Si+SiC nanopowders with a particle size of 50...100 nm, obtained by plasma chemical synthesis, was mixed for several hours in a special attritor with successive pressing of modifier tablets on an automatic press. Results. The technological process of modifying aluminum melts with a complex modifier was developed, the temperature and time parameters of the process were determined. Brinell hardness was measured on samples of AL4 and AL4C alloys, 25x25 mm in size. As a result of the obtained data, it is observed that in the modified samples of the AL4 alloy, the hardness increased by 6.9%, and in the AL4C samples – by 4.8%. The obtained hardness measurement data are consistent with the results of testing the strength properties of alloys before and after modification. Originality. In the modified alloys, a higher fluidity than in the initial state and a homogeneous dispersed microstructure were obtained. Practical value. In the modified alloys, an increase in strength properties was achieved: σv by 9 - 10%; σ0.2 by 11-12%, while maintaining the level of plasticity. The impact strength of modified alloys is significantly increased by 20-30%. As a result of the conducted studies of the structure and properties of cast alloys AL4 and AL4C, the effect of modification with nanodisperse compositions was confirmed.
Application of modern fractal formalism methods for researching the influence of ion-plasma coatings on assessing the wear resistance of volume hydraulic drive components
Authors: Hlushkova Diana , Bagrov Valeriy , Volchuk Volodymyr
Published: December 2023

Problem. The studies on preparation and application of Ti–Cr–N coating on the surface of the 38Х2МЮА steel have been conducted. Goal. The purpose of the work is to investigate the feasibility of using a fractal approach to evaluate the effect of plasma coatings to increase the wear resistance of parts of a volumetric hydraulic drive.  Methodology. Cr was chosen as the material for ion bombardment, since it makes it possible to reduce the temperature of the substrate before applying ­the coating and avoid the risk of surface softening. After heat treatment of the 38Х2МЮА steel, its hardness ranges from 40 to 45 HRC. The thickness of the applied coating varied from 3 to 6 microns, which corresponds to good adhesion, a smaller thickness does not significantly affect the properties of the product, and in the case of a thickness of more than 6 microns, peeling is observed due to poor adhesion to the substrate. Results. Five series of experiments with HRC hardness values of 42, 43, 44, 45, 46 were performed. Fractal analysis was used to assess the effect of the Ti–Cr–N coating structure of the working surface of volumetric hydraulic drive parts on its wear indicators. The relative error in calculating wear indicators for fractal models ranged from 0.04 to 8.96. The correlation coefficient of Y(X2) model without using indicators of the surface fractal dimension was only 0.73. Experiments proved that the lowest wear value of 2.11 g*10-3 was obtained at a coating thickness of 6 µm and hardness of 45 HRC. At the same time, a roughness coefficient was 0.16. To confirm this hypothesis, an experiment to determine wear resistance at a hardness of 45, roughness of 0.16, and coating thickness of 6 was conducted. Conclusions. Results of the studies of wear indicators of Ti–Cr–N coated samples at the substrate material hardness values from 42 to 46 HRC, surface roughness and coating thickness showed feasibility of the fractal structure estimation approach.
The influence of rolling at subcritical temperatures on the low-carbon steel structure and properties formation
Authors: Kotova Tetiana , Nosko Olha , Aiupova Tetyana , Volynchuk Vladyslav
Published: December 2023

Problem. In practice, the rolling of a low-carbon steel sheet due to significant heat losses ends  in the austenite – ferrite two-phase structure region, which leads to the metal heterogeneous structure formation, that decreases the sheet steel properties of the and its ability to be drawn.

Adverse temperature conditions characteristic of traditional hot rolling technology can be prevented by metal processing in the single-phase ferrite structure region below the critical point Ar1. Rolling of a thin sheet in the subcritical temperature range will ensure obtaining a uniform metal structure, which determines the level of its mechanical properties, as well as the quality of stamped parts

Goal. The purpose of the work is study the rolling modes influence at subcritical temperatures on the low-carbon steel structure and properties formation.Methodology. The microstructure of 08ps steel samples was studied using a metallographic and electron microscope JSM-840 with a "Link-860/|500" microanalysis system, the 08ps steel samples cross-section fine structure was studied using an electron microscope JEM - 200Сx. The metal mechanical properties complex was determined by standard tensile test methods.Results. The 08ps steel structure and properties after rolling at subcritical temperatures were studied. The comparative analysis of the fine structure of the initial blank and deformed samples of low-carbon steel was carried out. It was established that changes are observed in the structure of the deformed samples and the initial blank, which indicate the polygonization and recrystallization processes implementation and do not provide the of metal mechanical properties level provided for by DSTU 2834-94.Originality. Тhe thin structure of a 08ps steel sheet deformed in the subcritical temperature range with air cooling was studied. The development differs in the temperatures of the beginning and end of rolling, as well as the cooling rate in the post-deformation period. It allows  to expand theoretical ideas about the patterns of 08ps deformed steel structure formation and to use them in practice. Practical value. The results of the work can be applied in determining rational processing modes, which involve rolling at subcritical temperatures, to increase the complex metal properties and obtain high-quality parts by cold stamping.
Сучасний концепт участі тиреоїдних антигенів та цитокінів в імунопатогенезі автоімунного тиреоїдиту. Огляд літератури
Authors: Гладких Ф. В.
Published: December 2023

Автоімунні захворювання (АІЗ) щитоподібної залози (ЩЗ) — це опосередковані Т‑клітинами органо­специфічні автоімунні розлади, що виникають внаслідок зміненої відповіді імунної системи та характеризуються порушенням толерантності імунної системи до тканини ЩЗ.
Мета роботи — узагальнити сучасні відомості про роль тиреоїдних антигенів і цитокінів в імунопатогенезі автоімунного тиреоїдиту.
Пошук публікацій, у яких наведено відомості про імунопатогенез автоімунного тиреоїдиту, проведено у базах даних PubMed, Clinical Key Elsevier, Cochrane Library, eBook Business Collection та Google Scholar.
Основними тиреоїдними антигенами, які можуть індукувати опосередковану антитілом відповідь, є рецептор тиреотропного гормону, тиреоглобулін і тиреоїдна пероксидаза. Описано також такі антигени, як пендрин та симпортер Na+/I–. Автоімунні реакції при АІЗ ЩЗ являють собою два протилежні патогенетичні процеси з різними клінічними виявами. При хворобі Грейвса активовані Т‑клітини CD4+ спонукають В‑клітини виділяти тиреотропні імуноглобуліни проти рецептора тиреотропного гормону, що призводить до необмеженого вироблення гормонів ЩЗ і гіпертиреозу. При тиреоїдиті Хашимото самореактивні CD4+‑Т‑лімфоцити рекрутують В‑клітини та CD8+‑Т‑клітини у ЩЗ. Прогресування захворювання призводить до загибелі клітин ЩЗ і гіпотиреозу. Як автоантитіла, так і тиреоїдні специфічні цитотоксичні Т‑лімфоцити, вважають відповідальними за автоімунне виснаження тиреоцитів.
Схильність до АІЗ ЩЗ визначається поєднанням імунного механізму, генетичних чинників, чинників довкілля та конституційних чинників. Усі форми тиреоїдного автоімунітету пов’язані з лімфоцитарним інфільтратом у ЩЗ. При АІЗ ЩЗ інфільтрація ЩЗ Th1/Th2, Th17 і T‑reg супроводжується утворенням низки цитокінів та хемокінів, які відіграють важливу роль у патогенезі як хвороби Грейвса, так і автоімунного тиреоїдиту.
Клінічний випадок лікування загруднинного зоба великого розміру з використанням для діагностики та планування оперативного втручання індивідуально виготовлених пластикових прототипів за 3D-технологією
Authors: Галузинська О. І. , Кваченюк А. М. , Мороз В. В.
Published: December 2023

Загруднинний зоб може довго залишатися недіаг­ностованим аж до появи симптомів компресії. При оперативному втручанні важливе значення має розташування щитоподібної залози (ЩЗ) щодо суміжних органів, судин і нервів. Найпоширеніший спосіб візуалізації новоутворень ЩЗ — ультразвукове дослідження. Запропоновано новий метод дослідження для своєчасної діагностики новоутворень ЩЗ. Пацієнту з виявленим новоутворенням ЩЗ проводять променеве дослідження. Двовимірне зображення ЩЗ на комп’ютерній томограмі з використанням контрастної речовини аналізує лікар‑спеціаліст, який обирає площини найкращої візуалізації певного сегмента. Для побудови моделі використовують фронтальну, сагітальну, аксіальну площини, для цифрових даних — файли формату DICOM. За допомогою спеціальних програм файли формату DICOM переводять у формат STL, який є основним для адитивної технології тривимірного зображення та друку. Проводять експорт збереженого файла у форматі STL у програму Autdesk NetFab. Для переведення готової комп’ютерної 3D‑вимірної моделі на принтер використовують пошарове наплавлювання пластичного матеріалу для виготовлення моделі із застосуванням різних типів пластику та принтерів (fusing deposition modeling). Для твердого пластику PLA використовували принтер Flashforge guider II та програми Flash Print, для еластичного пластику Primalloy — принтер Klema з програмним забезпеченням Kura. Після формування та друку моделі оцінювали такі параметри органокомплексу ЩЗ, як розмір, форма, анатомічна будова та розташування щодо сусідніх органів. Розробляли персоніфікований спосіб оперативного втручання. Наведено опис клінічного випадку пацієнтки віком 66 років з лівобічним вузловим еутиреоїдним зобом ІІ ступеня та загруднинним розташуванням ЩЗ. Виконано КТ органів шиї з контрастуванням. За отриманими даними проведено 3D‑реконструкцію. На підставі отриманих даних та макета розроблено план оперативного втручання, змодельовано віртуально оперативне втручання до операції. Виконано лівобічну гемітирео­їдектомію з пухлиною. Під час ревізії регіональних метастазів не виявлено. Післяопераційний період без ускладнень. Голос збережений, акт ковтання не порушений. Додаткові методи лікування після операції не застосовували. Запропонований метод дає змогу отримати високоякісну 3D‑вимірну модель із кольоровим картуванням та виготовленням пластикового прототипу на доопераційному етапі та розробити техніку оперативного втручання на макеті.
Effect of irrigation water salinity on morphological and physiological characteristics of celery
Authors: KAYA Gamze
Published: December 2023

The objective of this study was to investigate the effects of salinity levels of irrigation water on the morphological and physiological characteristics of celery (Apium graveolens L.) during early seedling development. Celery seedlings of Balena cultivar were grown with saline irrigation water consisting of different NaCl levels (0, 50, 100, 150, 200, 250, and 300 mM). The results showed that increasing salt stress inhibited plant growth by destroying physiological parameters. Each increase in NaCl resulted in a decrease in the length, diameter, number, and fresh and dry weight of leaves. Dry matter, chlorophyll content, leaf temperature, and turgor loss improved when NaCl levels were increased; however, salinity caused a reduction in leaf relative water content. Leaf fresh and dry weights were lower under salt stress, even at 50 mM NaCl. Leaf temperature was higher in plants grown under salinity and reached the maximum level at 100 mM NaCl. The stomata on the abaxial side of the leaves were smaller but more numerous under salinity than in the control plants. It was concluded that celery’s plant growth was significantly influenced by salinity and that it could endure salinity lower than 100 mM NaCl.
Renovation of natural grass football fields using carpet-based hybrid method: The case of Atatürk Olympic Stadium
Authors: HOCAOĞLU Tuğrul , BİNGÖL Bora
Published: December 2023

Since the playability and performance of hybrid turf pitches reflect natural grass pitch standards, they have been used in Europe for more than 20 years and have been frequently preferred in Turkey recently. Although hybrid turf systems are installed on football fields by various methods, the most popular one is the carpet-based hybrid method. These types of fields can be built from scratch or by renewing natural grass fields. When renovating natural grass fields, it should be considered that the processes and applications have a complex structure and the works should be carried out within a certain system. In this study, the renovation of the playing surface of the Atatürk Olympic Stadium, which is expected to host the UEFA Champions League Final in 2020, from natural grass to carpet-based hybrid grass has been examined. All renovation works were meticulously observed on site and the experiences gained were tried to be conveyed. In this way, it is aimed that the study will serve as a guide for future renovation work. Due to the complex nature of the renovation process, it is important to have the necessary knowledge when carrying out these operations. Since the renovation of these areas is expensive, it is important to ensure the necessary conditions are provided. The correct materials, essential technical equipment, and skilled personnel must be provided for the operations to be carried out, and measures must be taken to prevent any potential problems that may arise during the renovation phase.
El copamiento de La Tablada y el Movimiento al Socialismo: posicionamientos políticos y discursos públicos
Authors: Lopez Rodrigo
Published: December 2023

En este artículo analizamos los posicionamien­tos políticos y los discursos públicos del Movimiento al Socialismo (MAS) ante el copamiento a La Tablada llevado adelante en enero de 1989 por el Movimiento Todos por la Patria (MTP). Partimos de la hipótesis de que este acontecimiento se presentó como un hecho sumamente dilemático para las izquierdas argentinas que las enfrentó con una serie de problemáticas que habían estado parcialmente ocluidas desde que se puso en marcha el proceso de democratización en 1983. Este trabajo pretende problematizar la postura de condena adoptada por el MAS ante la acción del MTP y reparar en los debates partidarios tanto internos como externos a la organización. Para ello se plantean algunos interrogantes, entre ellos el más importante es en qué medida los consensos democráticos construidos desde la caída de la última dictadura militar desempeñaron un papel en la definición de dichos posicionamientos.
El consumo del Oriente. Representaciones orientalistas en los avisos publicitarios de la prensa porteña hacia inicios del siglo XX (1900-1925)
Authors: Alderete Matías
Published: December 2023

Durante los últimos años, se han producido prolíficos estudios sobre el orientalismo argentino, señalando que este no es un fenómeno foráneo o marginal dentro de la cultura. El periodo de entresiglo ha sido señalado como relevante para observar su importancia, haciendo hincapié en la inmediata posguerra y abocándose en el análisis de las concepciones orientalistas de intelectuales y eruditos.
La circulación de las representaciones orientalistas en la cultura masiva no ha recibido la misma atención. La presente investigación se propone explorar las construcciones y representaciones del Oriente en los avisos publicitarios de inicios del siglo XX. Es posible encontrar en la prensa porteña ciertos indicios que permitan indagar cómo se configuró un imaginario orientalista en un período que ha sido señalado como punto de partida de la configuración del consumo masivo. Especialmente, se analizará cómo el Oriente sedujo a los consumidores al recurrir a valores como la eficacia y la distinción; especialmente, productos de uso femenino explotaron el tópico sensual del orientalismo para publicitarse, representando al Oriente como un espacio mágico y libidinoso.
Todavía más sobre Romanización
Authors: Bancalari Molina Alejandro
Published: December 2023

El presente estudio tiene como propósito central revisar los diversos enfoques, teorías y debates sobre el proceso de romanización. Se otorgará un énfasis especial a los paradigmas de las dos últimas décadas y sus nuevas narrativas, centrándose en la teoría de la globalización. Además, se enfatizará cómo este fenómeno de interconexión multicultural y de redes proporciona un modelo para reestudiar la naturaleza y el funcionamiento del imperio romano. Un tema abierto, por cierto, todavía vigente.
DPP4 Regulates the Th17/IL-17 Axis and Accelerates Epithelial Mesenchymal Transition to Promote Ovalbumin-Induced Asthma in Female C57BL/6J Mice
Authors: Li Linqiao , Ling Feixiang , Li Rou , Jiang Yan , Long Haiyan , Xiao Bo , Wu Jingjie , Long Zhiheng , Ma Libing
Published: December 2023

Background: Dipeptidyl peptidase-4 (DPP4) is a transmembrane glycoprotein, prevalent across a variety of tissues and cells and can be foundin a solubilised in peripheral blood. This paper aims at determining the role of sCD26/sDPP4 in Th17 cell polarization and airway epithelial cell to epithelial mesenchymal transition (EMT) in asthma. Methods: Female C57BL/6J mice were treated with ovalbumin to constructed asthma mice. The CD4+ T cell, and bronchial epithelial cells (BECs) were purified from the spleens and bronchus of mice. The KRT8 expression in BECs were identified by immunofluorescence (IF). Th17 cells were differentiated from a CD4+ T cell. Flow cytometry was usewd to identify and calculate the Th17 and Treg cells. Mice woth asthma were treated by DPP4 overexpressing lentivirus or DPP4 inhibitor. Histopathological modifications were assessed by hematoxylin-eosin (HE), periodic acid Schiff (PAS), and Masson staining. The total number of leucocytes was detected using a hemocytometer. For detection, quantitative Real-time PCR (qRT-PCR), western blotting (WB), and IF were used to evaluate the expression of E-cadherin and alpha-smooth muscle actin (α-SMA). Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the DPP4, IL-4, IL-5, IL-13 and IL-17 levels. Results: The findings suggest that sCD26/sDPP4 promote CD4+ T cells differentiation into Th17 cells in a depending on the applied dose. sCD26/sDPP4 up-regulated the expression of α-SMA and down-regulated the expression of E-cadherin in TGF-β1-induced mouse BECs, which was reversed by DPP4 inhibitor. Co-culture induced a synergic effect between Th17 cells and sCD26/sDPP4 on the formation of airway EMT in BECs. Furthermore, DPP4 inhibitor prevented lung-bronchial inflammatory infiltration, mucus secretion, goblet cell hyperplasia and collagen deposition in asthma mice. Meanwhile, DPP4 inhibitor decreased the levels of DPP4, IL-4, IL-5, IL-13, IL-17 and increased the total number of leukocytes in bronchoalveolar lavage fluid of asthma mice. In addition, DPP4 inhibitor also inhibited airway EMT and Th17 cell polarization in asthma mice. Conclusions: The results in this paper show that up-regulation of DPP4 enabled airway inflammation and airway remodeling in asthmatic mice by modulating the Th17/IL-17 axis and accelerating the airway EMT, which isa therapeutic target in asthma.
ATF4 Responds to Metabolic Stress in Drosophila
Authors: Ok Soonhyuck , Park Jung-Eun , Byun Seunghee , Kang Kwonyoon , Son Jaekyoung , Kang Min-Ji
Published: December 2023

Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response. ATF4 regulates adaptive gene expression, thereby triggering stress resistance in cells. Methods: To characterize the metabolic status of atf4-⁣/- Drosophila larvae, we conducted both metabolomic and microarray analyses. Results: Metabolomic analysis demonstrated an increase in lactate levels in atf4-⁣/- mutants when compared to wild-type flies. However, there was a significant reduction in adenosine triphosphate (ATP) synthesis in the atf4-⁣/- flies, suggesting an abnormal energy metabolism in the mutant larvae. Microarray analysis unveiled that Drosophila ATF4 controls gene expression related to diverse biological processes, including lipase activity, oxidoreductase activity, acyltransferase, immune response, cell death, and transcription factor, particularly under nutrient-restricted conditions. In situ hybridization analysis further demonstrated specific augmentation of CG6283, classified as a gastric lipase, within the gastric caeca of nutrient-restricted flies. Moreover, overexpression of lipases, CG6283 and CG6295, made the flies resistant to starvation. Conclusions: These findings underscore the role of Drosophila ATF4 in responding to metabolic fluctuations and modulating gene expression associated with metabolism and stress adaptation. Dysregulation of ATF4 may detrimentally impact the development and physiology of Drosophila.
Metabolite Profiling and Comparative Metabolomics Analysis of Jiaozhou Chinese Cabbage (Brassica rapa L. ssp. pekinensis) Planted in Different Areas
Authors: Li Jingjuan , Qiu Minghui , Ritonga Faujiah Nurhasanah , Wang Fengde , Zhou Dandan , Li Cheng , Li Huayin , Zhang Yihui , Gao Jianwei
Published: December 2023

Background: Chinese cabbage (Brassica rapa L. ssp. pekinensis) is one of the most popular vegetables in China because of its taste and health benefits. The area of production has obvious effects on the quality of Chinese cabbage. However, metabolite profiling and variations in different production areas are still unclear. Methods: Here, widely targeted metabolite analyses based on the ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach were performed to study the metabolite profiling of Chinese cabbage planted in the Jiaozhou and Jinan areas. Results: A total of 531 metabolites were detected, of which 529 were present in the Chinese cabbage from both areas, 108 were found to be chemicals related to Chinese traditional medicine, and 79 were found to correspond to at least one disease. Chinese cabbage is rich in nutritious substances such as lipids, phenolic acids, amino acids and derivatives, nucleotides and derivatives, organic acids, flavonoids, glucosinolates, saccharides, alcohols, and vitamins. Comparative analysis showed that the metabolic profiles differed between areas, and 89 differentially altered metabolites (DAMs) were characterized. Of these, 78 DAMs showed higher levels in Jinan Chinese cabbage, whereas 11 had higher levels in Jiaozhou Chinese cabbage. Two metabolites, S-(Methyl)glutathione and nicotinic acid adenine dinucleotide, were unique in Jiaozhou Chinese cabbage. Based on Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, the DAMs were enriched into 23 pathways, of which tryptophan metabolism and thiamine metabolism were the significant enrichment pathways. Conclusions: This study provides new insights into the metabolite profiles and production areas affecting the metabolite variations of Chinese cabbage, which will be useful for functional Chinese cabbage cultivation.
Cancer Stem Cell Biomarkers in the Nervous System
Authors: Li Xinyi , Huang Jiaqiang , Kang Yulin , Cheng Xiyu , Yan Qiong , Zhang Lishu , Fan Jingpu , Xu Hanli
Published: December 2023

Cancer stem cells (CSCs) have been increasingly recognized in recent years. CSCs from human neural tumors are one of the root causes of metastatic tumor progression, therapeutic resistance and recurrence. However, there is a lack of comprehensive literature that systematically consolidates the biomarkers specific to CSCs in neurological cancers. Therefore, this review provides a comprehensive summary of cancer stem cell (CSC) biomarkers for neurological tumors such as glioma, meningioma, medulloblastoma and neurofibroma. It also points out the possible functions of these biomarkers in diagnosis, treatment and prognosis, providing a broader perspective. First, we quantitatively screened key words such as CSCs, biomarkers, and expression by bibliometric analysis and clarified the intrinsic connections between the key words. Then, we describe the CSC biomarkers of major neurological tumors and their pathway mechanisms, and provide an in-depth analysis of the commonalities and differences with the biomarkers of non-CSCs. In addition, many studies have shown that antipsychotic drugs can inhibit tumor growth and reduce the expression of CSC biomarkers, which facilitates targeted therapy against tumors in the nervous system. Therefore, this study will focus on the biomarkers of CSCs in the nervous system, hoping to provide guidance for future in-depth exploration and monitoring of neurological tumors for clinical applications.
Effect of 5-aminolevulinic Acid on Mitochondrial Activity
Authors: Markina Yuliya V. , Markin Alexander M. , Kirichenko Tatiana V. , Tolstik Taisiya V. , Cherednichenko Vadim R. , Kiseleva Diana G. , Orekhov Alexander N.
Published: December 2023

Background: Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5-aminolevulinic acid. This study aimed to investigate the activity of mitochondria in cells with different mutation loads. Materials and Methods: The study was conducted using 11 cybrid lines obtained from the THP-1 cell line (a human monocytic leukemia cell line) and platelets of patients with different mitochondrial mutations. Results: Our results illustrate that 5-aminolevulinic acid was metabolized equally in all cell lines, however, there was a significant decrease in mitochondrial potential, which differed among lines. Conclusions: The results of this study can be used to develop a personalized therapeutic approach based on different mitochondrial activities.
MANAJEMEN PERSEDIAAN JUST-IN-TIME SEKTOR PUBLIK UNTUK LAYANAN PITA CUKAI
Authors: Biswan Ali Tafriji Biswan , Azhari Hasyim
Published: December 2023

Tuntutan masyarakat terhadap layanan prima membuat organisasi beradaptasi dan bersikap responsif dalam memenuhinya secara cepat dan tepat. Salah satu bentuk adaptasi dunia bisnis ke sektor publik adalah manajemen persediaan dengan sistem just-in-time. Meskipun pada mulanya diterapkan pada sektor bisnis, just-in-time selaras dengan karakter layanan sektor publik terkini. Studi ini bertujuan mengkonfirmasi layanan pita cukai di lingkungan Ditjen Bea dan Cukai berdasarkan karakteristik dan filosofi just-in-time. Metode kualitatif deskriptif digunakan dalam studi ini untuk menelusuri lebih mendalam proses bisnis objek studi. Hasil studi menunjukkan bahwa penggunaan aplikasi P3C dan CK-1 online dalam penyediaan dan pemesanan pita cukai merupakan wujud pull inventory system sebagaimana filosofi just-in-time. Tidak hanya untuk permintaan pokok, permintaan cukai tambahan juga menggunakan asas JIT. Bahkan dalam rangka efisiensi, pita cukai tak terpakai pihak pemesan mengganti biaya, sehingga efisiensi anggaran terjaga. Implikasinya layanan JIT hendaknya terus dikembangkan selaras perkembangan teknologi informasi.
Estimación de Precios de Bitcoin mediante Regresión Lineal Múltiple y Redes Neuronales
Authors: Díaz López Manuel Humberto , King-Domínguez Andrea , Améstica-Rivas Luis
Published: December 2023

Diversos estudios se han enfocado en estimar el precio de las criptomonedas utilizando modelos
de series de tiempo y variables estáticas. Este estudio se centra en la predicción del precio de Bitcoin, utilizando un modelo que combina la regresión lineal múltiple y las redes neuronales. Este enfoque permite identificar los factores que influyen en la volatilidad de Bitcoin y, mediante una selección dinámica de variables, detectar constantemente el conjunto de características más relevante para la predicción. Asimismo, se optimiza la cantidad de datos para mejorar la precisión y evitar la sobreutilización de información histórica. La combinación de estas técnicas permitió capturar patrones y tendencias subyacentes, aumentando la confiabilidad de las predicciones, con una precisión del 88%. Sin embargo, es crucial considerar la necesidad de evaluaciones continuas para adaptarse a las cambiantes condiciones del mercado. Este enfoque brinda una herramienta más precisa para tomar decisiones informadas en un mercado altamente volátil.
A lesson from COVID-19 pandemic: Developing a survival investment strategy to deal with crisis conditions
Authors: Rinaldo Dito , Vina Anggilia Puspita  , Binti Fatahul Ariffin Hazelena Dewi
Published: December 2023

This study introduces the novel concept of a stock investment strategy tailored to crises. It adopts a quantitative approach that tests various factors influencing stock price dynamics. In the first stage of the study, a multiple regression analysis is conducted, encompassing macroeconomic indicators such as Southeast Asian, Chinese, and American stock indexes, gold prices, and the impact of COVID-19 on stock prices. Subsequently, an additional examination assesses the influence of LQ-45 company performance on stock price formulation. Finally, a qualitative analysis is employed to scrutinize government policies implemented during the pandemic and their impact on Jakarta Composite Index (JCI) movements. As a result, it is found that all macroeconomic factors exert a significant negative influence on stock prices. Additionally, as COVID-19 cases surge, stock indexes in Southeast Asia, China, and America exhibit a substantial positive effect on stock prices. In contrast, firm performance and gold prices do not significantly affect stock price movements. Moreover, the market also reveals a more favorable response to government initiatives aimed at relaxing activity restrictions and positive developments in vaccination efforts. Lastly, based on the extensive analyses conducted in this study, we have identified four distinct investment strategies tailored explicitly for effectively navigating crises. These strategies encompass diversification, a prudent wait-and-see approach, the Richman party, and the Guerrilla strategy.
Financial Feasibility and Sensitivity of Arabica Coffee Farming In Simalungun District, Sumatra Utara Province
Authors: Yuliarti Ellys , Muhamad Mustopa Romdhon  , Saragih Luciana
Published: December 2023

Arabica coffee productivity in Simalungun Regency has the highest value, namely 1.25 tons/ha, among other arabica coffee producing districts in Sumatra Utara Province. However, the level of feasibility of return on investment made by farmers of arabica coffee has not been measured. The research method used to determine the feasibility and sensitivity of arabica coffee farming is Net B/C ratio, Gross B/C ratio, Profitability Ratio, Net Present Value and Internal Rate of Return. The results of the research show that arabica coffee farming is financially feasible based on the criteria of Net B/C Ratio (2.33), Gross B/C Ratio (1.38), Profitability Ratio (2.31), NPV (Rp. 23,194,329), and IRR (25.06%). The sensitivity of arabica coffee farming occurs if fertilizer and labor costs increase by 55% and production prices fall, then arabica coffee farming is not worth pursuing. Arabica coffee farming in Raya Huluan Village is financially feasible but farmers have not been able to independently cultivate arabica coffee properly. Therefore, farmers are given assistance on how to cultivate arabica coffee farming, types of fertilizer and dosage of fertilizer, timing of fertilizer application so that the economic life of arabica coffee is more than 10 years.