bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Ultrasonic Treatment and Hydrogen Donor Addition on the Viscosity of Iraqi Heavy Crude Oil
Authors: W. Azeez Athraa , Q. Hussein Hussein
Published: September 2024

يختبر البحث الحالي التأثيرات المشتركة للإشعاع بالموجات فوق الصوتية والمادة المانحة للهيدروجين على لزوجة النفط الخام الثقيل. تمت دراسة تأثير زمن التعرض للموجات فوق الصوتية والطاقة ودورة التشغيل ودرجة الحرارة على لزوجة النفط الخام العراقي الثقيل الذي يملك قيمة .20.32 = API كما تم فحص لزوجة عينات النفط الخام التي تم خلطها بمانح الهيدروجين (Decalin) وإخضاعها للمعالجة بالموجات فوق الصوتية في ظل الظروف المثالية، لتقييم التأثير المشترك للإشعاع بالموجات فوق الصوتية والمانح للهيدروجين على لزوجة النفط الخام. شهدت اللزوجة انخفاضًا بنسبة 52.34 % بعد دقيقتين من التعرض للموجات فوق الصوتية، عند طاقة 360 W ، دورة تشغيل 0.8، 35 درجة مئوية، وأضافه %8 نسبة حجمية من Decalin. للتحقق من صحة نتائج التجارب، تم إجراء فحص محتوى الأسفلتين، محتوى الكبريت، API، واختبار التقطير على كل من العينة الاولية و النهائية (في ظل الظروف المثلى). وأظهرت تراكيز الأسفلتين والكبريت انخفاضا قدره37.51 % و%35.04 على التوالي. تشير النتائج إلى أن ظاهرة التجويف وظاهرة الحرارة والتأثير الميكانيكي للموجات فوق الصوتية قد تساهم في تكسير سلاسل الكربون الممتدة وتقليل حجم الإسفلتين المتجمع مما يؤدي إلى انخفاض لزوجة النفط الخام. علاوة على ذلك، أظهرت النتائج أن التطبيق المتزامن للموجات فوق الصوتية والمادة المانحة للهيدروجين أدى إلى انخفاض كبير في لزوجة النفط الخام عند مقارنته بالنفط الخام غير المعالج أو المعالج بالموجات فوق الصوتية فقط.
Fusion of Probabilistic Projections of Sea-Level Rise
Authors: Grandey Benjamin S. , Dauwels Justin , Koh Zhi Yang , Horton Benjamin P. , Chew Lock Yue
Published: September 2024

A probabilistic projection of sea-level rise uses a probability distribution to represent scientific uncertainty. However, alternative probabilistic projections of sea-level rise differ markedly, revealing ambiguity, which poses a challenge to scientific assessment and decision-making. To address the challenge of ambiguity, we propose a new approach to quantify a best estimate of the scientific uncertainty associated with sea-level rise. Our proposed fusion combines the complementary strengths of the ice sheet models and expert elicitations that were used in the Sixth Assessment Report (AR6) of the Intergovernmental Panel on Climate Change (IPCC). Under a low-emissions scenario, the fusion’s very likely range of global mean sea-level rise is 0.3–1.0 m by 2100. Under a high-emissions scenario, the very likely range is 0.5–1.9 m. The 95th percentile projection of 1.9 m can inform a high-end storyline, supporting decision-making for activities with low uncertainty tolerance. By quantifying a best estimate of scientific uncertainty, the fusion caters to diverse users.
Study on the Mechanism of Online PE Learning Performance: Mediating Effect of Interactions
Authors: Zhang Qi , Chen Shan Ping
Published: September 2024

Introduction: With the rapid development of Internet technology and its wide application in education, online education has become an important way for people to learn knowledge in the digital era. Due to the time-space separation teachers and students, as well as their lack of face-to-face communication during online learning, it is difficult to accurately estimate the learning performance of online physical education (PE). Therefore, the relationship among teachers’ instructional activity (IA) , students’ sports activity and ability (SAA), and online PE learning performance (LP), as well as the mediating effect of interactions (IB), are mainly studied in this paper.
Methods: Through the questionnaire of online PE learning activity, this paper investigated the online PE learning situation of 691 college students in Shaanxi Province. SPSS26.0 was used for description and correlation analysis of the variables, and then AMOS26.0 version was used to draw a structural equation modeling. The bias-corrected non-parametric percentage Bootstrap method (5000 repeated samples) was selected to estimate the 95% confidence interval (CI) and test the mediating effect of interactions.
Results: (1) There is a significant positive correlation (p<0.001) among four variables. (2) A structural equation model with interactions as the mediating variable was established. All fitting test values of the corrected model reached the fitting standards(c2/df=4.494, P＜0.001, RMSEA=0.071, GFI=0.910，NFI=0.938, CFI=0.951, IFI=0.951), so that the mediating effect has been persuasive. (3) According to the corrected model path coefficients, IA can explain 30.6% and 25.6% of the variation of IB and LP, SAA can explain 32.3% and 45.8% of the variation of IB and LP, while IB can directly explain 9% of the variation of LP. (4) The effects of IA, SAA, IB, and LP did not contain 0 in the upper and lower limits of the bootstrap95% CI, indicating that the mediating effect of interactions has been persuasive.
Conclusion: (1) Both teachers’ instructional activity and students’ sports activity and ability can exert a positive impact on learning performance. (2) Teachers’ instructional activity is the decisive factor for students participate in learning. Teachers can improve the quality of interactions through teaching behavior, thereby improving students’ learning performance. (3) Students’ sports activity and ability are the driving force for their participate in learning. The stronger students’ sports activity and ability are, the more active they will be in classroom interaction and the better learning performance they will get. (4) Interactions can play a crucial role in learning performance, because the occurrence of interactions can effectively enhance the initiative of students and the classroom interest.
Study of CRP, Ferritin and D-Dimer in Covid-19 RICU Patients as per HRCT severity in Assiut University Hospitals
Authors: Abdel-Ghany Mohamed F. , Farouk Atef , author) Mina Ibraheem Anis (corresponding , Youssif Sahar Farghly
Published: September 2024

Background
Patients with Coronavirus disease (COVID-19) was found to exhibit elevated levels of inflammatory cytokines, which were linked to pulmonary inflammation, lung damage, and end with multi-organ failure.C-reactive protein (CRP), serum ferritin and D dimer levels may predict severity and mortality. Radiology plays a key role in the diagnosis, management, and follow-up of this disease. We attempted to describe the radiological features of SARS-CoV-2 infection in its original form, to correlate the HRCT patterns with clinical findings, C-reactive protein (CRP), D-dimer and ferritin and to consider as predictors of morbidity and mortality in adult (ICU) patients with COVID-19.
Methods
This prospective cross-sectional analytic work had been conducted on 159 patients aged ≥ 18 years old, admitted at Assiut University Hospital Respiratory ICU from November 2021 to November 2022, diagnosed as COVID-19 by positive RT-PCR. All cases were categorized on bases of (HRCT chest) disease reporting and data system (CO-RADS) scoring classification.Oxygen saturation, and inflammatory markers such as CRP, Ferritin and D dimer were measured. Age, sex, comorbidities, use of MV mechanical ventilation, and outcomes as per HRCT severity were key observations.
Results
A total of 159 HRCT chest scans of symptomatic RT-PCR-positive ICU patients were recruited. Higher CRP and Ferritinserum levels, lower lymphocytic count, higher frequency of need for mechanical ventilation were significantly greater in the severe group as assessed by HRCT severity score (CORAD 4,5) (P < 0.0001)). Predictors of severity revealedCRP at cut off > 133 mg/dlserum level, had 65.7% overall accuracywith AUC: 0.673(OR:2.19(P < 0.0001)),DM (OR:3.45(P < 0.0001)), chronic chest disease (OR:2.22(P < 0.0001)). Mortality predictors were age (OR:1.78(P < 0.0001)), DM (OR:2.89(P < 0.0001)), chronic chest disease (OR:3.01(P < 0.0001)), serum CRP levels (OR:2.11(P < 0.0001)). Need for mechanical ventilation and mortality rate as regards CT severity score were 76(66%),75 (65%), versus 3(7%) 4(9%) between severe and non-severe groups respectively (P < 0.0001).
Conclusions
High-resolution computed tomography (HRCT) scan of the chest as well as CRP and ferritin plasma levels are valuable methodsand significant predictors for future prognosis in patients with covid19 at risk of death and in need for MV.
Optimization based on Multi-Meme Memetic Algorithm
Authors: Mirsaleh Mehdi Rezapoor , Meybody Mohammad Reza
Published: September 2024

In this paper a new learning automata-based Multi-Meme memetic algorithm which is obtained from combination of learning automata (LA) and memetic algorithm (MA) is proposed for optimization problems. This algorithm is composed of two parts, genetic section and memetic section. Genetic section operates based on the irregular cellular learning automata (ICLA) which is a generalization of cellular learning automata (CLA) in which the restriction of rectangular grid structure in CLA is removed. Memetic section consists of a pool of memes in which each meme is correspond to a certain local search method and represented by a set of LAs by which the history of the corresponding local search method can be extracted. To show the superiority of our proposed algorithm over the some well-known algorithms, several computer experiments have been conducted. The obtained results show that the new algorithm performs better that other methods in terms of running time of algorithm and required number of colors.
NaMoO2PO4 glass ceramic nanocomposite as a novel cathode material for magnesium-ion batteries
Authors: Wally N K , Sheha E. , Morad Ibrahim , El-Desoky M. M.
Published: September 2024

Unlocking superior Mg-ion cells with good cycling performance as a future battery candidate is now crucial. However, structural instability is mainly reported in current oxide frameworks. Additionally, poor diffusion kinetics are typical due to the affinity of Mg2+ ions to interact with oxide anions. Herein, NMoP-0 glass was obtained according to the molar ratio 20 Na2S to 40 MoO3-40 P2O5 mol%. NMoP-0 was thermally treated to obtain NMoP-8 and NMoP-12 glass ceramic nanocomposites (GCN) to obtain the desired NaMoO2PO4. XRD identified the crystal structure of NMoP-12 to be NaMoO2PO4 with a crystallite size of 38 nm. The electrodes were tested by EIS, CV and GCD in three and two electrode systems, both confirming their reversible electrochemical activity. The initial specific capacitance values of NMoP-0, NMoP-8 and NMoP-12 in Mg-ion cells were estimated to be 214, 82 and 130 mAh g− 1, respectively. Meanwhile, the NMoP-12 cells showed the best capacity retention behavior and a diffusion coefficient ∼ 10−14, which means that Mg2+ ions diffusion in NMoP-12 is moderately favorable. This promising performance of NaMoO2PO4 GCN suggests its potential as a novel cathode material for magnesium-ion batteries, sparking hope for future advancements in battery technology.
Can Lung Function Be Used as a Predictor of Cerebral Stroke?
Authors: Elgendy Walid I.M. , Anas Dalia , Nageeb Rania S. , Hassan Hanan A. , Lotfy Samah
Published: September 2024

objectives
Limited studies have explored the specific relationship between pulmonary function, arterial blood gases, and cerebral stroke. This study aims to investigate the relationship between lung function and carotid intima-media thickness (CIMT) in cerebral stroke and non-stroke patients without chronic pulmonary disease.
Methods
A case control study included 125 cerebral stroke patients and 125 non-stroke controls selected from the outpatient clinics of the Neurology and Rheumatology & Rehabilitation departments at Zagazig University Hospital, Sharkia Governorate, Egypt. Lung function was assessed using the forced vital capacity (FVC) maneuver. Arterial blood gases were measured, and CIMT was evaluated using high-resolution ultrasonography by trained physicians.
Results
The results revealed a higher risk of cerebral stroke in patients with elevated CIMT compared to those with normal CIMT. An inverse relationship was observed between lung function, expressed as FVC, FEV1/FVC, and MVV, and arterial blood gases, expressed as PaO2, with CIMT. Reduced FVC, FEV1/FVC, MVV, and PaO2 were associated with elevated CIMT. The stepwise multivariable regression model showed that CIMT was directly related to age and FEV1 and inversely related to FVC, FEV1/FVC, PaO2, and MVV.
Conclusion
Patients with elevated CIMT have a higher risk of cerebral stroke. Reduced FVC, FEV1/FVC, MVV, and PaO2 are associated with elevated CIMT. These findings suggest that lung function tests could be useful in screening individuals without respiratory disease who are at high risk for cerebral stroke.
Quasar radiation dramatically transforms the gas in a merging companion galaxy
Authors: Balashev Sergei , Noterdaeme Pasquier , Gupta Neeraj , Krogager Jens-Kristian , Combes Francoise , Lopez Sebastian , Petitjean Patrick , Omont Alain , Srian Ranghunathan , Cuellar Rodrigo
Published: September 2024

Quasars, powered by gas accretion onto supermassive black holes at the centers of massive galaxies, rank among the Universe’s most energetic objects. Galaxy mergers have been proposed as pivotal events in fueling these supermassive black holes, igniting quasars into their active, luminous phase. The subsequent tremendous energy release is then anticipated to impact the quasar’s surroundings, influencing morphology, gas and star-formation properties, not only in the quasar host but also in companion galaxies. However, evidence supporting merging galaxies as primary feeding mechanism remains scarce and feedback effects on gas properties lack observational constraints, in particular on its small-scale structure. Here we unveil a major merging system at redshift 𝑧 ≈ 2.7 (approximately 2.5 billion years post Big Bang), and demonstrate that the gas properties in the merging companion galaxy are directly and dramatically altered by the quasar radiation. Our findings reveal that the quasar-host and companion galaxies, with centroids separated by only a few kiloparsecs and approaching each other at speed ≈ 550 km s−1, are both massive, form stars, and contain a substantial molecular mass. Yet, dusty molecular gas seen in absorption against the quasar nucleus is highly excited and confined within cloudlets of sizes <0.01 pc and densities ∼ 105 - 106 cm−3, several orders of magnitude more compact than those observed in non-quasar environments and approximately 105 times smaller than the scales attainable in emission. We infer that, wherever exposed to the quasar radiation, molecular gas is disrupted, leaving behind surviving dense clouds too small to give birth to new stars. Our results not only underscore the role of major galaxy mergers in triggering quasar and star-formation activity, but also reveal localized negative feedback as a profound alteration of internal gas structure which hampers star formation.
Evolução dos direitos humanos no combate à violência de gênero: Uma análise da meta 5.2 dos Objetivos Desenvolvimento Sustentável da Agenda 2030
Authors: Figueiredo César Alessandro Sagrillo , Da Silva Helen Fabrícia Armando
Published: September 2024

A violência de gênero é um fenômeno social global que atinge países signatários da Organização das Nações Unidas (ONU), de maneiras diferentes, mas tendo em comum a violação dos direitos humanos femininos, conforme previsto na Convenção sobre a Eliminação de Todas as Formas de Discriminação contra as Mulheres de 1979. Recentemente, foi anunciada Agenda 2030 da ONU, com Objetivo Desenvolvimento Sustentável 5 visando a igualdade de gênero e empoderamento feminino, bem como a Meta 5.2 tendo como finalidade eliminar a violência de gênero. Assim, possuímos como objeto o estudo da evolução dos direitos humanos femininos, por conseguinte, os seus instrumentos legais de combate a violência de gênero. Isso posto, em face da da Agenda 2030 da ONU, nosso objetivo principal é analisar de maneira crítica a Meta 5.2 dos Objetivos de Desenvolvimento Sustentável. No tocante a metodologia empregada, tratar-se-á de uma abordagem qualitativa, no qual é trabalhado com a pesquisa exploratória, bem como é realizado a revisão bibliográfica e reconstituição histórica sobre o tema com o levantamento de dados estatísticos sobre o objeto. Como resultado da pesquisa é constatado que existe um movimento mundial no sentido de mitigar a desigualdade de gênero, assim como tentando diminuir a violência de gênero, ainda que o Brasil apresenta problemas estruturais e sociais que dificultam o alcance completo da Meta 5.2, sobretudo políticas públicas nessa seara ainda são insuficientes e ainda requer um trabalho mais aperfeiçoado e efetivo.
COMPARISON BETWEEN THE USE OF PANORAMIC RADIOGRAPHY AND CONE BEAM COMPUTED TOMOGRAPHY TO LOCATE DENTAL ELEMENTS SEVERE INTRUDED DUE TO TRAUMA: CASE REPORT
Authors: Rebouças Pedro Diniz , Rodrigues Lorena Walesca Macedo , Santiago Adriana Kelly de Sousa , Milagres Clarice Santana , Gondim Juliana Oliveira , Moreira-Neto José Jeová Siebra
Published: September 2024

Intrusive luxation is a kind of traumatic injury characterized by an axial displacement of the tooth toward the alveolar bone. Its main causes are bicycle accidents, sports/recreational activities, and falls or collisions. Treatment strategies include waiting for the tooth to return to its position, immediate surgical repositioning and repositioning through dental traction by orthodontic devices. The correct diagnosis must be based on clinical and radiographic exams and it is crucial for decision-making in the treatment of injured patients. Currently, the cone beam computed tomography (CBCT) has been widely used in orthodontics, restorative dentistry and implantology as well as in the diagnosis of complex dental trauma. This article reports a case of severe dental intrusion, in which the cone beam computed tomography (CBCT) was performed because of doubts generated after clinical examination and panoramic radiograph analyze. This case report confirmed that the CBCT is an important exam to correct diagnostic.
ACESSIBILIDADE E RESOLUTIVIDADE DOS SERVIÇOS DE SAÚDE: PERSPECTIVAS DE USUÁRIOS E PROFISSIONAIS.
Authors: Santos Tatiana Vasques Camelo dos , Penna Cláudia Maria de Mattos
Published: September 2024

Estudo de caso qualitativo fundamentado na Sociologia Compreensiva do Cotidiano, realizado em 3 unidades de ESF e no UPA no município de Manhuaçu – MG, com o objetivo de compreender, na percepção de usuários e profissionais, a resolutividade das ações desenvolvidas no âmbito dos serviços de saúde. Para tanto, foram realizadas entrevistas com 20 profissionais e 17 usuários. Os dados foram submetidos à análise de conteúdo. As questões de baixa resolutividade estão ligadas à acessibilidade organizacional. Já na percepção dos usuários, o serviço resolutivo é o produto do encontro entre as demandas por ele sentidas, a oferta de serviços e o tempo gasto para que sua necessidade seja atendida. Porém, se a demanda apresentada pelo usuário não encontrar a oferta adequada de serviços (tecnologias, pacote de serviços demorados ou inoportunos), as ações não o serão.
APRESENTAÇÂO
Authors: Acadêmico Editores Pensar
Published: September 2024

Revista da Faculdade de Ciências Gerenciais de Manhuaçu – FACIG (ISSN 1808-6136). Pensar Acadêmico, Manhuaçu, MG, v. 13, n. 2, Julho-Dezembro, 2015.
ANÁLISE COMPARATIVA DO REGIME ORDINÁRIO LUCRO PRESUMIDO PARA O PROJETO DE LEI COMPLEMENTAR (PLP) 125/2015 DO SIMPLES NACIONAL
Authors: Leite Alex Santiago , Lang Agnes Cristina Wiedemann , Costa Mônica Oliveira
Published: September 2024

O Simples Nacional regido pela Lei Complementar nº 123, de 14 de dezembro de 2006, juntamente com suas alterações, trouxe a promessa de um regime único diferenciado e favorecido a ser dispensado às microempresas e empresas de pequeno porte, principalmente no que se refere à apuração e arrecadação de tributos. Com a criação do projeto de Lei Complementar nº 125 de 2015, que pretende alterar a LC nº 123/06, novos limites de enquadramentos e um sistema progressivo de alíquotas e deduções, abrangendo mais empresas com esse benefício. Assim, o presente estudo analisou a melhor forma de tributação para uma empresa do ramo comercial alimentício com faturamento superior a R$ 3.600.000,00, tendo como base as seguintes formas de tributação: Simples Nacional com ênfase no projeto de lei 125/2015 e Lucro Presumido. A fim de tornar concreto este objetivo, foi realizado um estudo a respeito das características de cada regime, bem como de todas as variáveis que influenciaram a realização do mesmo. Além disso, foram apresentadas as sistemáticas de tributação do Simples Nacional e do Lucro Presumido, comparando os dois regimes tributários. Para viabilizar tal comparação, o trabalho apresentou um estudo de caso no qual foi apurada a carga tributária incidente sobre a receita bruta auferida por uma empresa aqui denominada Empresa Alfa no período 2015, tendo em vista as formas de tributação citadas anteriormente e observou-se que o Lucro Presumido é a forma de tributação mais econômica para a Empresa Alfa.
Solar Light-Induced Synthesis of Biologically Active Compounds
Authors: Das Aparna , Ray Devalina , Waqar Ashraf Muhammad , Banik Bimal Krishna
Published: September 2024

Over the past few years, photocatalytic methods have shown great promise as low-cost,
environmentally friendly, and sustainable technologies. During the development of photochemistry,
a variety of sources of light were used, including sunlight, compact fluorescent lamps, lasers,
and even light-emitting diodes. As a part of preparing diverse organic compounds, the photochemical
approach was used, for instance, to form rings, arylated compounds, cycloaddition, functionalized
compounds, dehalogenated compounds, oxidized compounds, reduced compounds, isomers,
and sensitized compounds. Solar energy is a renewable resource that can be harvested from
the sun and this light energy can be changed into chemical energy with the help of photocatalysts.
During this green approach, electron-hole pairs are generated in photocatalysts in order to begin
reactions by using solar light. It has been highlighted in this article that there have been impressive
developments in the use of light, mainly the solar light, to promote important organic reactions,
which would otherwise be unattainable under thermal conditions.
PIM Kinase Inhibitors as Novel Promising Therapeutic Scaffolds in Cancer Therapy
Authors: Karati Dipanjan , Saha Ankur , Roy Souvik , Mukherjee Swarupananda
Published: September 2024

:

Cancer involves the uncontrolled, abnormal growth of cells and affects other tissues.
Kinase has an impact on proliferating the cells and causing cancer. For the purpose of treating cancer,
PIM kinase is a potential target. The pro-viral Integration site for moloney murine leukaemia
virus (PIM) kinases is responsible for the tumorigenesis, by phosphorylating the proteins that control
the cell cycle and cell proliferation. PIM-1, PIM-2, and PIM-3 are the three distinct isoforms of
PIM kinases. The JAK/STAT pathway is essential for controlling how PIM genes are expressed.
PIM kinase is also linked withPI3K/AKT/mTOR pathway in various types of cancers. The overexpression
of PIM kinase will cause cancer. Currently, there are significant efforts being made in
medication design and development to target its inhibition. A few small chemical inhibitors (E.g.,
SGI-1776, AZD1208, LGH447) that specifically target the PIM proteins' adenosine triphosphate
(ATP)-binding domain have been identified. PIM kinase antagonists have a remarkable effect on
different types of cancer. Despite conducting clinical trials on SGI-1776, the first PIM inhibitory
agent, was prematurely withdrawn, making it unable to generate concept evidence. On the other
hand, in recent years, it has aided in hastening the identification of multiple new PIM inhibitors.
Cyanopyridines and Pyrazolo[1,5-a]pyrimidinecan act as potent PIM kinase inhibitors for cancer
therapy. We explore the involvement of oncogenic transcription factor c-Mycandmi-RNA in relation
to PIM kinase. In this article, we highlight the oncogenic effects, and structural insights into PIM
kinase inhibitors for the treatment of cancer.
Design, Synthesis, Anti-Proliferative Effects, and Mechanistic Details of Fluorine-Containing Biguanide Derivatives with Various Carbon Rings
Authors: Xie Yijun , Zhang Qingtong , Xiao Di , Deng Meiling , Liu Yan , Duan Huaxin , Yang Xiaoping
Published: September 2024

Introduction/Objective:

Biguanide derivatives are small molecules with promising antitumor
activity. However, the effect of different carbon rings at the end of one guanide group of
these compounds on anti-proliferation activity is unknown. Therefore, we synthesized novel fluorine-
containing biguanide compounds with various carbon rings, evaluated their anticancer activities,
and explored their anti-proliferative mechanisms.

Methods:

Guanidine derivatives containing trifluoromethoxy or 3,4-difluorophenyl with nine different
carbon rings were synthesized using established chemical methods. The phenyl side chain
was fixed to trifluoromethoxy or 3,4-difluorophenyl with changes in the number of cyclic aminocyclic
carbons. The effects of these derivatives were evaluated using MTT and clonogenic assays,
while the underlying mechanisms were investigated by analyzing protein expression levels via
western blotting.

Results:

This study analyzed the effects of new biguanide derivatives on cell growth in three different
cell lines: HepG2, Ovcar3, and T24. The results showed that T24 cells were the most sensitive
cell line to these biguanides. All biguanide derivatives significantly inhibited the growth of T24
cells, while compound 4b exhibited the strongest inhibition in all three cell lines by MTT assay.
The inhibitory effects of 4b were further confirmed using colony formation experiments. Western
blotting results indicated that the representative biguanide derivative, 4b, inhibited the EGFR signaling
pathway, thereby inhibiting tumor growth.

Conclusion:

1a-5a and 1b-4b, the cyclooctyl-containing 3,4-difluorophenyl biguanide analogs,
have demonstrated significant potential in developing novel anticancer drugs. The 3,4-
difluorophenyl biguanide containing cyclooctyl showed the best antitumor activity among the nine
derivatives. This finding offers a novel perspective in developing anticancer drugs and a further
improvement in biguanide activity in the future.
Epidemiology and Genetic Architecture of Type 2 Diabetes Mellitus in Geographically Different Indian Populations: A Review
Authors: Singh Jyotsna , Tripathi Vijay , Kant Rajiv , Lal Jonathan A.
Published: September 2024

:

Type 2 Diabetes Mellitus (T2DM) has been a severe public health issue
worldwide for many years. The primary cause and risk factor of T2DM is hereditary and
complicated interaction between epigenetics. Identification and understanding of genetic
markers may help to detect, prevent, and manage T2DM. This review examined the effect
of single-gene and gene-gene interactions for predicting diabetes mellitus. Based on the
literature survey, common and unique Single Nucleotide Polymorphisms (SNPs) and
genes were explored in the Indian Populations, including PPARG, TCF7L2, KCNJ11,
CDKN2A, IGF2BP2, SLC30A8, HHEX and CDKAL1. Identifying common and specific
markers may help in risk prediction and early detection of T2DM. Future research and
Genome-wide association studies are also required to predict the gene-gene interaction,
generate large data sets for removing non-representative groups, and focus only on specific
marker-associated traits.
Short-term Uridine Treatment Alleviates Endoplasmic Reticulum Stress via Regulating Inflammation and Oxidative Stress in Lithium-Pilocarpine Model of Status Epilepticus
Authors: Aydin Birnur , Koc Cansu , Cansev Mehmet , Alkan Tulin
Published: September 2024

Background:

Status Epilepticus (SE) leads to the development of epilepsy with the contribution of Endoplasmic Reticulum (ER) stress. Uridine, a pyrimidine
nucleoside, has been shown to have neuroprotective and antiepileptogenic effects in animal models. This study aimed to determine whether uridine
ameliorates ER stress and apoptosis following epileptogenic insult. Secondly, this study aimed to establish the effect of uridine on inflammatory
and oxidative stress parameters that contribute to ER stress.

Methods:

Status epilepticus was induced using lithium-pilocarpine in adult male Sprague-Dawley rats. Following SE termination, rats were treated with
uridine, 4-phenylbutyric acid (4-PBA), or saline twice daily for 48 h. Expressions of hippocampal glucose-regulated protein 78 (GRP78), Inositol-
Requiring Protein 1 (IRE1α), Protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK), and C/EBP Homologous Protein (CHOP) were
determined by western blotting 48 h after SE. Uridine's effects on apoptosis, inflammation or oxidation were evaluated by analyses of cleaved
caspase-3 and poly(ADP-ribose) polymerase 1 (PARP1) protein expressions or pro-inflammatory cytokine levels or levels of oxidative stress
markers, respectively.

Results:

Expressions of all ER stress-related proteins significantly increased 48 h after SE. Uridine treatment markedly decreased GRP78, IRE1α, and
CHOP levels. A decrease in the PERK level was observed following the administration of 4-PBA; however, uridine had no effect. Cleaved
caspase-3 and PARP1 levels were increased in the SHAM group, while uridine and 4-PBA treatment effectively decreased their expressions.
Treatment with uridine significantly reduced Myeloperoxidase (MPO) and Malondialdehyde (MDA) levels while tending to increase Catalase
(CAT) and Glutathione Peroxidase (GPx) levels. Uridine treatment also significantly attenuated levels of TNF-α and IL-1β, the pro-inflammatory
cytokines, which increased 48 h post-SE.

Conclusion:

Our data indicate that uridine alleviates ER stress after SE. This effect may be attributed to the regulation of inflammation and oxidative stress.
Uridine shows promise as a potential preventive agent for epilepsy.
The Biological Effects and Mechanisms of Fisetin on Hepatotoxicity, Liver Injury, and Liver Fibrosis: A Systematic Review
Authors: Rahimian Ghorbanali , Heidari-Soureshjani Saeid , Kasiri Karamali
Published: September 2024

Background:

Liver disease is a common cause of death worldwide.

Objectives:

This study aims to investigate the effects and mechanisms of Fisetin on hepatotoxicity,
liver injury, and liver fibrosis.

Methods:

We adhered to the PRISMA 2020 guidelines in this systematic review. Our search used
MeSH keywords encompassed Embase, PubMed, Web of Science, Scopus, and Cochrane Library for
articles published before March 2, 2024. Relevant data was extracted from the publications, meticulously
recorded in a standard form, and subsequently reviewed for outcomes and mechanisms.

Results:

Fisetin protects hepatocytes from oxidative stress by neutralizing free radicals (O2
−and
H2O2), reduces oxidative stress, prevents lipid peroxidation, and increases endogenous antioxidants.
It also reduces inflammation via lowering the production of tumor necrosis factor α (TNF-α), interleukins
(IL)1α, IL-6, IL-18, IL-1β suppressing nuclear factor kappa B (NF-κB) activation, and cyclooxygenase-
2 (COX-2), inducible nitric oxide synthase (iNOS) inhibition, reducing monocyte
chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor 1 (PAI-1), NLR family pyrin
domain-containing 3 (NLRP3) inflammasome and interferon-gamma (IFN‐γ). Moreover, it inhibited
apoptosis-modulated enzyme activity and detoxification enzymes via modulating the activity of cytochrome
P450 and Phase II detoxification enzymes. Fisetin prevented fibrosis by inhibiting the activation
of hepatic stellate cells (HSCs), attenuating extracellular matrix (ECM) remodeling-associated
genes, and suppressing transforming growth factor-β (TGF-β) signaling pathway and attenuating
collagen production. It decreased lipid accumulation and liver function tests.

Conclusion:

In vivo and in vitro studies indicated that Fisetin can enhance detoxification, attenuate
liver injury, and reduce fibrosis, which helps maintain liver health.
A Review of the Impact of the COVID-19 Pandemic on Lifestyle Behaviors
Authors: Mehraeen Esmaeil , Pashaei Ava , Mousavi Heydar , Yarmohammadi Soudabeh
Published: September 2024

Introduction/Objective:

Although the COVID-19 pandemic primarily affected human
health and medicine, it has also had positive and negative impacts on various aspects of life. Hence,
this research aimed to explore the impact of the COVID-19 epidemic on lifestyle behaviors.

Methods:

The current research was a review conducted in 2023. PubMed, Scopus, and Google
Scholar databases were searched using standard keywords. Related articles were included in the
study after qualitative review and inclusion and exclusion criteria were applied, and data were extracted.

Results:

In the current research, 32 articles were included. Most reviewed studies referred to decreased
physical activity (78.12%), unhealthy dietary habits (65.62%), and sleep disturbance (56.25),
as the most affected lifestyle behaviors following the COVID-19 situation. Among the age groups,
the 18-89-year-old group reported more smoking and alcohol consumption than the other groups, and
the 1-21-year-old group reported the least smoking and alcohol consumption. Also, the age groups of
1 to 21 years and 18 to 69 years reported psychological problems, such as depression, anxiety, and
stress, compared to other age groups. There has been a relationship between overweight and reduced
physical activity, increased consumption of fast food and sweets, and also between decreased income
and increased mental problems, increased consumption of cigarettes and alcoholic beverages, and
decreased consumption of fruits and vegetables.

Conclusion:

The outbreak of the COVID-19 pandemic has had a significant impact on people's lifestyles,
which can negatively affect overall health and well-being. The combination of reduced physical
activity, unhealthy eating habits, and poor sleep has become a common consequence of the pandemic.
By recognizing the potential negative impacts of reduced physical activity, unhealthy eating
habits, and poor sleep, individuals can take steps to mitigate these effects.
What the French Working Conditions Surveys Tell Us
Authors: Bué Jennifer , Coutrot Thomas , Hamon-Cholet Sylvie , Dunn Mary Lee
Published: September 2024

Since 1978, France's Ministry of Labour and the National Statistical Institute (INSEE) have carried out four large-scale sample surveys on working conditions among approximately 20,000 workers, questioned by survey-takers at home, that provide invaluable descriptive information on how work is changing [1]. The last survey published was from 1998, and the 2005 survey is being processed at the time of writing. Taking a lead from this example among others, the European Commission tasked the European Foundation for the Improvement of Living and Working Conditions to carry out similar surveys in EU countries in 1990, 1995, 2000, and now 2005. Between them, these surveys portray an alarming situation where workers are seeing their working conditions getting worse [2]. Another survey using a different methodology, carried out by occupational doctors during health checks on 50,000 workers—the Sumer survey, from the French acronym for the health risk screening program—done for the Ministry of Labour in 1994 and 2003, points to the same general trends. In both France and the broader European Union (EU), physical demands and risks are not lessening, mental workload is growing, working hours are more diverse and less regular, work paces more demanding, compressed deadlines reduce job predictability and task discretion.… But at the same time, workers report having more leeway in discharging responsibilities that have expanded due to the rise in skill levels and new forms of work organization.
River Sedimentation Due to Tin Mining Activities in Bangka Island
Authors: Hambali Roby , Tae Lee Sung , Bachtiar Huda , Denansyah Faisal Ilyas , Pamungkas Aditya
Published: September 2024

Sedimentation in rivers is a major issue of environmental damage in the Kepulauan Bangka Belitung Province. In the last two decades, since tin mining was carried out by the community, massive sedimentation has occurred in the river. The purpose of the study is to investigate the characteristics of sediment materials and the effects of illegal tin mining on river sedimentation on Bangka Island. Sediment characteristics can be seen from the distribution of grain size and specific gravity of the bed sediment material and the concentration of suspended sediments seen from their position along the river. Sediment grain size is classified according to the American Geophysical Union. A total of 45 sediment samples spread across 12 rivers in the district capital area on Bangka Island were collected at the end of the rainy season in 2023, and 4 more samples were added in the dry season of 2023 in the Muntok River. The MPM formula was applied to estimate bedload transport and statistical methods were used to estimate suspended sediment rates. Additionally, the sedimentation rates are estimated based on dependable continuous flow with a probability exceeding 50% (Q50%). The study’s findings indicate that Illegal tin mining in Bangka Island has a major impact on river sedimentation. The particle size distribution of bed material sediments does not align with what is typically found in nature, which often exhibits coarser particles upstream and finer downstream. Similarly, in areas downstream of tin mining operations, the concentration of suspended particles increases significantly, up to 12 times higher than natural conditions.
Integrating the Survey of Regional Rural Cultural Inheritance into the Teaching Practice of Communication Studies
Authors: Liang Hongyan
Published: September 2024

In China, communication studies, as a discipline, have a history of more than ten years, but as a secondary discipline under “journalism and communication studies”, communication education has no its own characteristics from traditional journalism education. The talent cultivation model that not only focuses on cultivating students’ social science theoretical qualities, but also on cultivating practical skills and professional practical abilities has not yet been formed. In order to cultivate students’ social awareness in professional practice, the study explores, for the regional universities in China, how to incorporate regional cultural characteristic elements into cultivating journalism and communication talents with the construction of a “practice-oriented” applied communication talent training model.
BIENESTAR SOCIOEMOCIONAL E IMPACTO EN EL RENDIMIENTO ESCOLAR POST-PANDEMIA
Authors: Gervacio Jiménez Herlinda , Castillo Elías Benjamín , Albarran Gervacio Venecia
Published: September 2024

El objetivo de este estudio fue analizar la correlación entre las variables, salud socioemocional ante la post-pandemia y la afectación al rendimiento escolar. En la investigación participaron 168 estudiantes de nivel básico con una edad promedio de 14 años. Para determinar las correlaciones entre ambas variables, se aplicaron análisis estadístico de correlación Rho de Spearman para medir el grado de asociación entre las variables y las pruebas “D” de Somers y prueba “Gamma” como medidas simétricas de asociación entre las dos variables ordinales. Adicionalmente se analizó el resultado de las frecuencias con cuatro variables relacionadas, y estructuradas en dimensiones para fortalecer el análisis de la correlación entre las dos variables mencionadas. Los resultados de estas pruebas estadísticas demostraron que los estudiantes presentaron durante y posterior a la pandemia del Covid-19 una tendencia a la baja en su rendimiento escolar dada las condiciones de la salud y bienestar socioemocional, indicando una correlación de interdependencia entre ambas variables. De igual forma, en la escala de frecuencias, se observaron los porcentajes más elevados en siempre, casi siempre y algunas veces. En este sentido se concluyó que existe un área de oportunidad para la aplicación de un currículum transversal debido a la falta de formación socioemocional.
Investigación de la ionosfera a latitudes bajas e intermedias de México
Authors: Rodríguez Martínez Mario , Pérez Enriquez H. Román , Carrillo Vargas Armando , Haro Corzo Sinhué A. E.
Published: September 2024

La ionosfera terrestre es una región localizada entre los 80 y 600 kilómetro de altura cuyo plasma está formado por iones y electrones libres. Diariamente, la ionosfera presenta una dinámica con significativas diferencias entre el día y la noche terrestre, con procesos de fotoionización y súbitos cambios en la velocidad del viento solar, las Eyecciones de Masa Coronal (EMC) y los Eventos Solares de Protones (SPE) . Los compiladores de esta obra, Mario Rodríguez-Martínez, H. Román Pérez-Enríquez, Armando Carrillo-Vargas y Sinhué A. R. Haro-Corzo, reunieron trabajos presentados durante el taller “Investigación de la ionosfera a latitudes bajas e intermedias de México” celebrado en la ciudad de Morelia y en el municipio de Coeneo, Michoacán, durante abril de 2013. La reunión de estos artículos resalta la necesidad de impulsar estos estudios así como la necesidad de contar con servicios confiables de monitores constantes en este campo de conocimiento.
Temas Selectos en Ciencia de Materiales y Nanotecnología 2021
Authors: Núñez González José , Santiago de la Cruz Arlette Arizbe , Navarro Chávez Oracio , Vargas Ortega Joel , Raya Montaño Alfredo , Ruiz Camou César Rodrigo , Medina de la Torre Joaquín , Reyes Montero Armando
Published: September 2024

El libro Temas Selectos en Ciencia de Materiales y Nanotecnología 2021 es el resultado de una colaboración entre el Instituto de Investigaciones en Materiales y la Escuela Nacional de Estudios Superiores ambos en la Unidad Morelia de la UNAM. El libro se presenta como las memorias de la XVI Escuela de Ciencia de Materiales y Nanotecnología, que tuvo lugar en las instalaciones del campus de la UNAM en Morelia, del 8 al 12 de noviembre del 2021, organizada por el Instituto de Investigaciones en Materiales y la Licenciatura en Ciencia de Materiales Sustentable (LCMS), campus Morelia. El libro cuenta con 4 capítulos, el primero presenta de una manera didáctica la ecuación de Dirac y algunas de sus aplicaciones. El nivel de dificultad del texto requiere lectores con un buen nivel de física como los estudiantes de semestres avanzados de la LCMS. Los otros capítulos presentan temas de gran actualidad en la investigación de ciencias de materiales, como el análisis del ciclo de vida para la determinación del impacto ambiental de los materiales (capítulo 2), los nanoalambres (capítulo 3) y las cerámicas piezoeléctricas (capítulo 4).
Polifuncionalidad en lingüística
Authors: Pérez Álvarez Bernardo A.
Published: September 2024

El presente volumen tiene como objetivo explicar un concepto clave en teoría lingüística: el de polifuncionalidad. Para ello, se reúnen seis capítulos que abordan el tema de la polifuncionalidad en dos niveles: uno teórico, donde se explica la polifuncionalidad, y uno específico, en el que se describe cómo opera esta en diferentes ámbitos y niveles de la lengua. De esta manera, el libro en su conjunto constituye una explicación abarcadora, no únicamente de la polifuncionalidad, sino de sus diferentes manifestaciones en diferentes niveles y planos de análisis lingüístico, para llegar a la conclusión de que la polifuncionalidad es una operación lingüística constitutiva de todo sistema, que incluso permite replantear algunas ideas clásicas sobre la lengua, como que un signo lingüístico tenga su propio significado y que en la comunicación se altera, o bien que se pueda estudiar al sistema de manera separada de la comunicación, por los errores que cometen los hablantes al comunicarse. Por el contrario, el funcionamiento de la lengua debe entenderse vinculado a la comunicación, como un engranaje complejo entre niveles y planos de análisis lingüístico en el que las unidades se ajustan constantemente al movimiento de la lengua cuando los hablantes se comunican.
Una amistad en la distancia: epistolario José Enrique Rodó y Rufino Fombona Blanco (1897-1916)
Authors: Cesana Raffaele
Published: September 2024

Las cartas que dan corpus a este epistolario entre José Enrique Rodó y Rufino Blanco Fombona, 1897-1916, ‒y que se atesoran en la Colección José Enrique Rodó, en el Archivo Literario de la Biblioteca Nacional de Uruguay‒, son una fuente histórica extraordinaria que pone en evidencia al idealismo latinoamericanista y al corporativismo bolivariano de la cultura y la sociabilidad intelectual de la América Latina de esa época. Esta edición crítica organiza y presenta cronológicamente las cartas e incluye notas que pretenden actualizar la enciclopedia del lector, en especial la de un lector no familiarizado con el universo del discurso, los códigos, el lenguaje y los temas de los dos corresponsales. Así, con esta información, será posible leer el epistolario y percibir la importancia de Rodó y Blanco Fombona en el contexto hispanoamericano novecentista y modernista y, de igual manera, resignificar las empatías, los ideales y las diferencias que moldearon una amistad en la distancia.
Seven Critical Attributes for Selecting an NDC API Partner in the Airline Industry
Authors: Mohammed Shahan Taj
Published: September 2024

This article examines seven critical attributes that airlines should consider when selecting an NDC API partner for enhancing their distribution capabilities. These attributes include technical skill, airline industry knowledge, project management experience, travel industry market knowledge, quality and operational excellence, NDC certification, and futureproofing capabilities. By evaluating potential partners based on these criteria, airlines can ensure successful NDC implementation and establish strategic distribution partnerships. The article provides insights into each attribute, highlighting their importance in the context of the evolving airline distribution landscape and the challenges associated with NDC adoption. It emphasizes the significance of choosing the right partner to navigate the complexities of modern distribution, optimize offer management, and ultimately deliver superior value to customers
Detection of Essential Trace Element of Chromium by Electroanalytical Methods
Authors: Raees Dr. Mohd. , Dadhich Bhavesh , Pathan Dr. Imran Khan , Jakhar Jagdish Kumar
Published: September 2024

A detailed study of essential ultra trace element of chromium present many of industrial waste lakes of western rajasthan. Aconvinent method of electroanlytical technique used for the essential trace element present in the industrial waste water as a polarography method for identification of essential trace element by using concentration of ppm to ppb. According to this method prepare solution of sodium chromate as a stock and identify electroanalytical potential by using as a supporting electrolyte 0.05 M HCl + 0.25 M NaCl give a sharp peak at ࡱ૚ ૛ ൗ = 0.91(V) and result compare with other electroanalytical instrument like UV-Vis Sprctrophotometer, Atomic absorption spectroscopy