bluuebunny/crossref_metadata_2025 huggingface dataset:
Los edificios de La Salle en Bogotá 1900-1935
Authors: Coronado Ruiz Jairo Alberto
Published: June 2023

Los edificios escolares han sido y seguirán siendo un tema apasionante dentro del mundo proyectual del arquitecto y de la arquitectura. Constituyen el altar de la educación, donde la pedagogía genera sus diferentes variables para hacer de la enseñanza y el aprendizaje un matrimonio indisoluble. Día tras día el pensamiento del arquitecto reinterpreta el espacio y el hábitat escolar, y se encarga de transformar y mejorar esas instancias para generar un diálogo perfecto entre los usuarios: estudiantes y maestros. Concebir un hábitat escolar es un reto permanente, directamente relacionado con una escuela pedagógica, un estilo y un modelo pedagógico, traducido en una política educativa que, de manera diáfana, constituye la base conceptual de la proyección del espacio escolar. El presente trabajo pretende encontrar esas relaciones escondidas y sacarlas a flote dentro de la concepción de una arquitectura que podríamos llamar escolar lasallista, la cual enaltece todos los valores pedagógicos de una comunidad dedicada desde su creación a la educación y cuyo fundador, San Juan Bautista de La Salle, abrió el camino a la creación de un ambiente escolar adecuado para los más necesitados, y cómo poco a poco estas condiciones educativas fueron tomando fuerza y expandiéndose hasta convertirse en lenguajes y pensamientos pedagógicos innovadores, puestos en escena y traducidos en la arquitectura, en edificios sobrios pero amables en el hábitat escolar.
Constructing Muslim Identity in a Secular State: The Strategic Role of Two Singapore Islamic Organizations
Authors: Zulkifli  , Hasyim Syafiq , Mubarak M Zaki , Khitam Husnul , Helmi Muhammad Ishar
Published: June 2023

In Singapore, Islamic identity matters mainly because Muslims and Malays have special constitutional status. However, state policies seem to contradict the status while the community is still dealing with the problem of backwardness in educational and economic development. This article examines the profile and strategic role of two Islamic organizations, MUIS (Majlis Ugama Islam Singapura, the Islamic Religious Council of Singapore) and Pergas (Persatuan Ulama dan Guru-Guru Agama Islam Singapura, Singapore Islamic Scholars, and Religious Teachers Association), in accommodating the expression and reconstructing Singaporean Muslim identity. Through intensive library research and using an interdisciplinary approach from social constructivist and fiqh of minorities’ perspectives, this article found that both have played a very important role in the expression and construction of Singaporean Muslim identity. There have been dynamic contestation and cooperation between the state policies towards the Muslim community. However, the global effect of Islamist extremism and terrorism has united them in terms of religious thought, attitude, and the formulation of the ideal Singaporean Muslim identity. The changing process of their stances toward the government’s policies was effective due to the function of fiqh of minorities in contextualizing Islamic teachings in the context of Singapore as a secular state.
Pengaruh Pemberian Silika Terhadap Pertumbuhan dan Produksi Tanaman Jagung Pulut (Zea Mays Ceratina L.) Varietas Lokal Bojonegoro
Authors: Akbar Ok Syahdana , Eriani Munandar Denna
Published: June 2023

Maize is one of the cereal crops that produces carbohydrates after wheat and rice. Maize is the staple food in Indonesia after rice, so the need for corn plants continues to increase. Cultivation of local pulut corn has problems due to low production and limited land. The development of local rice cultivation of the Bojonegoro variety to produce plants with optimal growth and high yields can be carried out, one of which is through the provision of beneficial micro fertilizers, such as silica (SiO2). The provision of beneficial silica micro fertilizer with different doses is carried out to determine the right dose so that it can be used by maize farmers. Different methods of using silica doses can be practiced to improve photosynthetic characteristics and increase maize yields (zhiming et.al,2014). This study aims to determine the effect of micro beneficial silica fertilizer at various doses on local maize plants of the Bojonegoro variety. The research was carried out using a randomized block design with a dose of silica (SiO2) to local maize plants of the Bojonegoro variety given in 6 dose levels that 0kg/ha, 50kg/ha, 100kg/ha, 150 kg/ha, 200 kg/ha dan 250 kg/ha. The SiO2 treatment was arranged in 5 blocks so that 30 experimental units were obtained. Silica application was carried out twice at the age of 7 and 14 days after planting by sowing in a circle on the soil surface. The data were analyzed by Analysis of Variance (ANOVA) to knowing the effect of treatment. The treatments with significantly different effects were further tested with using Duncan’s multiple range test (DMRT) with =5%. The research aims knowing the best dose of Silika (SiO2) at different levels gave a positive effect on increasing the variables of plant chlorophyll count, stem diameter, root fresh weight, crown fresh weight, total fresh weight, flowering age, ear diameter, ear weight, ear length, seed weight, weight 100 seeds, number of stomata, and production potential. The best dose of silica treatment on plant seed weight, namely at 50 kg/ha to 100 kg/ha produced the best seed weight in the range of 75.06 to 84.66 g, which was significantly different from the control and other treatment doses.
Pengaruh Komposisi Media Hidroponik dan Konsentrasi Pupuk Cair Cucian Beras terhadap Pertumbuhan dan Hasil Tanaman Basil Merah (Ocium Basilicum L.)
Authors: Sucipto Fani Firmanda , Soeparjono Sigit
Published: June 2023

Modification of the nutrient solution in the red basil plant can be done hydroponically, because it is able to stimulate the synthesis of secondary metabolites of the basil plant so that the plant can easily get the necessary nutrients through the addition of nutrient doses. The application of liquid organic fertilizer can help the addition of nutrients, while the use of different planting media is expected to obtain a good combination for the cultivation process. This study used rice washing water with the trademark pandanwangi and a combination of planting media between husk charcoal, sand, and bokashi. This study used a factorial complete randomized design (4x3) and repeated 3 times. The factors used are the concentration of rice laundry liquid fertilizer (P), consisting of 4 levels: (P0) : Control 0%, (P1): Rice washing liquid fertilizer concentration 25%, (P2): Rice washing liquid fertilizer concentration 50%, (P3): Rice washing liquid fertilizer concentration 75%, and substrate media composition factor (Q), consisting of 3 levels: (Q1): Husk charcoal and sand 1:1, (Q2): Husk charcoal and bokasi 1:1,  (Q3): Husk charcoal, sand and bokasi 1:1:1. The observation variables in this study are plant height, number of leaves planted, leaf area, fresh weight of leaves, dry weight of leaves, fresh weight of plants, dry weight of plants and volume of roots. Based on the results of research that has been carried out, the results of the treatment obtained The interaction between the composition of the planting media and the addition of liquid fertilizer for rice laundry does not have a noticeable effect on all treatments except the root volume parameter. The composition treatment of the growing medium had an unreal effect on all treatments except plant height and leaf area with recommendations of husk charcoal:sand (1:1) for plant height and husk charcoal:bokasi (1:1) for leaf area. The treatment of adding concentration of liquid fertilizer to rice laundry has a noticeable effect on all treatments except the fresh weight of the leaves and the fresh weight of the plant with the best recommendation in applying the concentration of liquid fertilizer of rice laundry 25% perliter - 50% perliter on each plant.
Mitigasi Resiko: Studi Kasus Keikutsertaan Petani dalam Program Asuransi Usahatani Padi
Authors: Yanuarti Rizky , Ibanah Indah
Published: June 2023

Sustainability of agricultural sector, especially within rice commodity which still becomes the main food for most of Indonesian’s, needs attention. Rice farming faces variety of risks and uncertainty conditions such as floods, droughts, and pest attacks. Global climate change in recent years has exacerbated the effects of natural hazards. Agricultural insurance become one solution to overcome farming risk. But in fact, farmers participation level still low. The purpose of this study is to identify the factors that influence farmers' decisions to participate in Rice Farming Insurance (AUTP) as a government-facilitated risk mitigation measure. The study was conducted in Wuluhan Sub-District, Jember Regency with total sample of 130 farmers who were randomly selected. Primary data was collected through interviews by filling out a structured questionnaire. The collected data was processed using logistic regression analysis to determine factors that significantly influence farmers' decisions. The results showed that the risk aversion level, age, experience, land area and crop failure occurence due to pests attack had significance wald test value (partial test) of 0.000; 0.098; 0.022; 0.002; and 0.024. So it can be said that the five variables significantly influence the farmers' decision to participate in AUTP at the confidence level of 95% and 90%.
Gambaran Pola Asuh Orang Tua terhadap Tingkat Kejadian Stunting di Desa Ajung dan Glagahwero Kecamatan Kalisat
Authors: Fitria Putri Adinda Mega , Handayani Ari Tri Wanodyo , Yani Ristya Widi Endah
Published: June 2023

Stunting is a condition of toddlers who have a shorter body than toddlers their age which is caused by chronic malnutrition. Stunting is one of the nutritional problems experienced by children under five in the world today with a prevalence of 22.2%. The impact of stunting in children under five is an increase in the level of morbidity and mortality, susceptibility to disease, and degenerative disease problems in adulthood, and it can affect the level of intellectuality and cognitive abilities in toddlers. Parenting style is one of the indirect factors that play a role in the incidence of stunting, the low parenting style of parents can increase the risk of children under five experiencing stunting. The parenting style includes feeding practices, parenting practices, and utilization of health services. The aim of this research is to examine and analyze the description of parenting styles for children under five years of age with stunting in Kalisat. A descriptive observational study with a cross-sectional approach using purpossive sampling. The description of parenting style for stunting toddlers as seen from feeding practices and parenting practices shows poor parenting styles, while health service utilization shows good parenting styles. The incidence of stunting in children under five in the Glagahwero and Ajung Village of Kalisat can occur because the parenting style in feeding practices and parenting practices is included in bad criteria even though the utilization of health services is included in good criteria.
Aktivitas Antibakteri Bahan Cetak Berbasis Ekstrak Natrium Alginat dari Alga Merah (Kappaphycus alverezii) terhadap Lactobacillus acidophilus
Authors: Rahayu Putu Sadaka Putri , Praharani Depi , Probosari Niken , Indahyani Didin Erma , Barid Izzata
Published: June 2023

Alginate impression material is a material that is often used for impression tissue in the oral cavity, and can be one of the agents of infection transmission in dental practice. Microorganisms can adhere to the mold such as Lactobacillus acidophilus bacteria. L. acidophilus were isolated from active caries and were considered as secondary invaders in the dental caries invasion process. The development of impression materials that have antibacterial capabilities needs to be done, one of which is by using materials derived from red algae (Kappaphycus alverezii). This plant contains a lot of alginate which is the main components of the cell wall, consisting of calcium, magnesium, sodium and potassium alginate salts. Synthesizing sodium alginate from red algae and analyzing the antibacterial activity of sodium alginate-based impression materials from red algae against L. acidophilus. Extraction of alginate from red algae using the acid method and conversion of alginic acid to sodium alginate by adding NaOH. The impression material is made with the addition of sodium alginate. Antibacterial activity test by well diffusion method. This study consisted of 3 groups, namely control (K), red algae sodium alginate extract (P1), and impression material with red algae sodium alginate extract (P2). Groups K, P1 and P2 had an average inhibition zone of 0 mm, 15.56 mm, 17.22 mm, respectively. Kruskal Wallis and Mann Whitney test showed significant differences between groups. Impression material based on sodium alginate extract from red algae has strong antibacterial activity against L. acidophilus.
Pembesaran Gingiva Pada Pengguna Alat Ortodonti Cekat: Literature Review
Authors: Narulita Danti , Megawati Vera
Published: June 2023

Orthodontic tooth movement occurs due to tissue remodeling. The success of orthodontic treatment is affected by the strength of periodontal health, oral hygiene, and orthodontics. Users of orthodontic appliances have to maintain oral hygiene to avoid periodontal disease. The purpose of this study was to evaluate and review enlargement gingiva in orthodontic user. This literature review was conducted by searching for journals, case reports and research with the keywords "gingival enlargement", "fixed orthodontics" and "orthodontic mechanics". Research articles and their full texts can be accessed over a 10- year starting from 2011 to 2021. Based on this literature study, poor oral hygiene during orthodontic treatment cause complications in periodontal tissues. Orthodontic appliances in oral cavity affect biofilm accumulation and bacterial colonization and patients with periodontal tissues are more susceptible to swelling and bleeding. Gingival treatment includes surgical and non-surgical gingivectomy. Surgical treatment are conventional surgery (scalpel), electrosurgery (cautery), diode laser and chemosurgery. Non- surgical treatment after orthodontic treatment was completed there was oral hygiene instructions, scaling and root planning, the using of a toothbrush and interproximal treatment and recall scheduled.
Telaah Artikel: Implementasi Sistem Pembayaran Kapitasi pada Jaminan Kesehatan Nasional sebagai Strategi dalam Mengatasi Kesenjangan Pelayanan Kesehatan
Authors: Istiqomah Alia , Jayanti Irene Putri , Wijayanti Ratih , Hidayatullah Fahmi , Oktadewi Fitri Diah
Published: June 2023

National Health Insurance program changed the pattern of health financing in Indonesia from fee to service system to capitation system. The capitation system is expected to reduce the risk of the community's own health costs and overcome inequalities of health services. The purpose of this literature review is to analyze the implementation of capitation payment system in overcoming health services problems. Although the implementation of NHI in Indonesia helps to equalize health services, there are quite number of problems in implementing NHI with the capitation system, among others, not all of the population is covered as participants, inequality of health facilities, varied quality of health services, health human resources, and management of capitation funds, monitoring, non-optimal referral systems, and varied geographic conditions had potential for widening health inequalities between community groups. Public health services should not only focus on treating individuals who are sick, but can do more important things such as making efforts to prevent and improve health. The capitation payment system is the most effective system for solving health services problems even though its implementation still not optimal and there are several shortcomings that can be fixed.
English teachers’ perception and attitudes of scaffolding method in teaching academic writing: An exploratory study at universities in Vietnam
Authors: Mai Nguyen Ban , Hien Ta Huu , Phuong Nguyen Le Tuong
Published: June 2023

The primary aim of this research is to investigate the impact of utilizing the scaffolding method on teaching academic writing in the context of English as a Foreign Language (EFL) at universities in Vietnam. This mixed-method study examined the attitudes and perceptions of 88 EFL educators from diverse backgrounds and degree levels who were randomly selected for the research. Methodologically, data were gathered and analyzed using the appropriate methods for each instrument, including a questionnaire and focus group discussion (FGD). Theoretically, the study is a medley of relevant theories and approaches such as Vygotsky’s Sociocultural Theory of Learning, the Scaffolding theory, and the ‘High challenge - High support’ pedagogy. The results of this study suggest that participants used scaffolding to some extent and had strongly positive attitudes and perceptions regarding its practical aspects; however, the findings also revealed that the surveyed lecturers are deficient in the necessary knowledge and skills. In addition, the study's findings imply that EFL teachers need training on how to properly use scaffolding as a pedagogical strategy to facilitate teaching academic writing to EFL students.
Professional Characteristics and Liberal Arts Character of Classical Literature Education Text: Focusing on Its Status as a University’s Major Education
Authors:   The Research Of The Korean Classic, Han Chang Hun
Published: June 2023

Traditionally, there has been a general perception that universities are immersed in specialized research that creates new knowledge, and the contents of education established hereby are spread through secondary education. However, as Korean language education itself moved away from academic-centered knowledge education and moved to a communication-centered function center, classical literature education also has had a gradual change from the education content focusing on the existing literature theory and history of literature to education centered on the linguistic attributes of literature. Classical literature has two educational properties. One is a property that is constantly enjoyed and reinterpreted while being handed down over a long time, which has a certain emotional influence even today. This can be conceptualized as a liberal arts character. The other is the fact that it shows the original form of culture as a material that contains the appearance of life at the time. This gave it an academic status of acquiring literacy for classical texts. I attempt to conceptualize this in terms of professional characteristics. Every classical literature text has its own inherent value. However, even if the original text is valuable, it does not immediately acquire educational value. ‘Liberal arts’ refers to creative understanding or knowledge that is embodied through acquiring a certain cultural ideal, and its content changes according to the changing times or the cultural ideology of a nation. As an educational philosophy of classical literature, I emphasize that ‘culture’ has a meaning encompassing history and philosophy. Here, the concept that responds well to culture is considered liberal arts. At this time, in the case of Korea, attention is paid to the concept term of ‘culture’ in the composition of the curriculum. In the case of Japan, the concept term of ‘liberal arts’ is highlighted as important in the composition of the curriculum. Here, I will not make a value-based evaluation of the difference between the two countries. The difference in perception between the two countries is because each has its own historical background and reason. This trend comes to affect the university curriculum in Korea, and even in undergraduate major classes at universities, there has been a situation where we are thinking about new teaching methods. As a result, it shows the characteristics that flow from the existing professional characteristics to the strengthening of liberal arts characteristics.
Interaction of carbon nanotube, capped carbon nanotube, C60 fullerene, and C70 fullerene with virulence factors of Gram-negative and Gram-positive bacteria: The potential application for 3D-printed scaffolds
Authors: Alavi Mehran , Ashengroph Morahem , Mozafari M. R.
Published: June 2023

Antimicrobial application of carbon nanomaterials such as carbon nanotubes (CNTs), capped CNT, C60 fullerene, and C70 fullerene are increasing owing to their low cytotoxicity properties compared to other nanomaterials such as metallic nanoparticles. Enhanced mechanical property and antibacterial activity can be caused by incorporation of CNTs in 3-dimentional (3D) printed nanocomposites (NCs). Interruption of bacterial membrane resulting from cylindrical shape and high aspect ratio properties has been found as the prominent antibacterial mechanism of CNTs. However, unraveling interaction of CNT, capped CNT, C60 fullerene, and C70 fullerene with virulence factors of the main bacterial pathogenesis has not yet been known. Therefore, in the present study, interactions of CNT, capped CNT, C60, and C70 with the eight virulence factors including protein kinase A and ESX-secreted protein B of Mycobacterium tuberculosis, pseudomonas elastase and exotoxin A of Pseudomonas aeruginosa, alpha-hemolysin and penicillin binding protein 2a of Staphylococcus aureus and shiga toxin 2a and heat-labile enterotoxin of Escherichia coli have been evaluated by molecular docking method of AutoDock Vina. This study disclosed the binding strength followed the sequence CNT > capped CNT > C70 > C60 towards alpha-hemolysin of S. aureus compared to other virulence factors with values of -19.6, -18.8, -13.6, and -12.8 kcal/mol, respectively. The lowest and highest binding affinity were found for CNT against 1TII and 1MWT by binding energy values of 97.4 and -20.1 kcal/mol. The stability of CNT-1MWT complex at the different times has resulted according to the normal mode analysis of elNémo and iMOD servers. Future studies should be focused on improving cellular uptake of CNTs, capped CNTs, C70, and C60 by surface functionalization for active targeting of bacteria.
Predicting Commercial Building Energy Consumption Using a Multivariate Multilayered Long-Short Term Memory Time-Series Model
Authors: Dinh Tan Ngoc , Thirunavukkarasu Gokul Sidarth , Seyedmahmoudian Mehdi , Mekhilef Saad , Stojcevski Alex
Published: June 2023

The global demand for energy has been steadily increasing due to population growth, urbanization, and industrialization. Numerous researchers worldwide are striving to create precise forecasting models for predicting energy consumption to manage supply and demand effectively. In this research, a time-series forecasting model based on multivariate multilayered long short-term memory (LSTM) is proposed for forecasting energy consumption and tested using data obtained from commercial buildings in Melbourne, Australia: the Advanced Technologies Center, Advanced Manufacturing and Design Center, and Knox Innovation, Opportunity, and Sustainability Center buildings. This research specifically identifies the best forecasting method for subtropical conditions and evaluates its performance by comparing it with the most used methods at present, including LSTM, bidirectional LSTM, and linear regression. The proposed multivariate multilayered LSTM model was assessed by comparing mean average error (MAE), root-mean-square error (RMSE), and mean absolute percentage error (MAPE) values with and without labeled time. Results indicate that the proposed model exhibits optimal performance with improved precision and accuracy. Specifically, the proposed LSTM model achieved a decrease in MAE by 30%, RMSE by 25%, and MAPE by 20% compared to the LSTM method. Moreover, it outperformed the bidirectional LSTM method with a reduction in MAE by 10%, RMSE by 20%, and MAPE by 18%. Furthermore, the proposed model surpassed linear regression with a decrease in MAE by 2%, RMSE by 7%, and MAPE by 10%. These findings highlight the significant performance increase achieved by the proposed multivariate multilayered LSTM model in energy consumption forecasting.
Target Identification in Anti-tuberculosis Drug Discovery
Authors: Capela Rita , Félix Rita , Clariano Marta , Nunes Diogo , Perry Maria de Jesus , Lopes Francisca
Published: June 2023

Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB), a disease that alt-hough preventable and curable, remains a global epidemic due to the emergence of resistance and a latent form responsible for a long period of treatment. Drug discovery in TB is a challenging task due to the heterogeneity of the disease, the emergence of resistance and an uncomplete knowledge of the pathophysiology of the disease. The limited permeability of the cell wall and the presence of multiple efflux pumps remain a major barrier to achieve effective intracellular drug accumulation. While the complete genome sequence of Mtb has been determined and several potential protein targets have been validated, the lack of adequate models for in vitro and in vivo studies is a limit-ing factor in TB drug discovery programs. In current therapeutic regimens, less than 0.5% of bac-terial proteins are targeted being the biosynthesis of the cell wall and the energetic metabolism two of the most important processes exploited for TB chemotherapeutics. This review provides an overview on the current challenges in TB drug discovery and emerging Mtb druggable proteins, and how chemical probes for protein profiling enabled the identification of new targets and bi-omarkers, paving the way to disruptive therapeutic regimens and diagnostic tools.
A Welfare Protocol to Assess the Welfare of Huemul (Hippocamelus bisulcus) in Conservation Centers
Authors: Bombal Enrique , Manteca Xavier , Tallo-Parra Oriol
Published: June 2023

Animal welfare assessment protocols are important for identifying welfare problems in conservation programs. This study aimed to develop a baseline welfare protocol for the assessment of welfare in huemul (Hippocamelus bisulcus) in conservation centers. This protocol is based on the Welfare Quality® (WQ) framework for cattle, considering the available literature on the behaviours, ecology, conservation plans, captive management of this species, and welfare assessment protocols for other ungulate species. As a result, the protocol was specifically developed for huemuls and included four principles, 12 criteria, and 23 animal- and resource-based indicators. The 12 criteria of the WQ protocol were reduced to nine, and three new criteria were added because they were both feasible and essential for welfare assessment in captive huemuls. This protocol is mainly intended to identify welfare problems in endangered species in the context of conservation centers (reproduction, rescue, rehabilitation, or treatment centers). Thus, aggregation of different measures to obtain a global score has not been proposed. However, a scoring system that assigns a value on a 0-2 scale (0= No welfare concern; 1= welfare concern; 2= urgent welfare concern) is proposed for each category. Although further research is still needed to fully validate the protocol, this is the first development of a completed protocol for huemul welfare assessment.
Are Minority Forest Farmers Willing to Participate in Forest Man-Agement? Evidence from the Minority Regions of Southwest China
Authors: Li Ya , Chang Haiqing , Dou Yaquan , Zhao Xiaodi
Published: June 2023

Forest resources are an important material basis for ecological protection and economic devel-opment, and are responsible for the dual mission of guaranteeing national ecological safety and grain safety. Forest land is an important carrier of forest resources, and forest landowner is a direct component of forest land management. Forest landowners’ willingness to engage in forest man-agement affects whether the important value function of forest resources can be implemented. Are there differences in the willingness and behavior of forest management between ethnic minority foresters and ordinary foresters? How to stimulate the forest management willingness and behavior of forest farmers in ethnic minority areas?These questions will be about the realization of the value of forest resources. Through the analysis of 185 questionnaires in Yunnan Province, this paper clarifies the current situation of forest management of forest farmers in minority areas. Then, using the Sustainable Livelihoods Framework, we select three indicators including the socio-economic at-tributes of individual farmers, the cognition and experience of forest landowners, and policy guidance. And we use the binary logistic regression model to analyze the factors affecting the willingness of forester to participate in forest management. Through the above analysis, we find that: (1) Forest landowners' willingness to engage in forest management in minority regions is relatively high, at 71.98%. (2) Individual farmers’ socioeconomic attributes have the most significant degree of influence on willingness to engage in forest management, while forest landowners' cognitive and related experiences, policy guidance and other related variables influence willingness to engage in forest management at the macro level. (3) Literacy has a significant positive contribution to man-agement intentions, while forest land area, living standard, whether they are compensated by public welfare forest, and whether they participate in the project of returning farmland to forest and grass have a significant negative effect on management intentions. (4) There are significant differences between forest landowners' willingness to engage in forest management and the influencing factors between minority regions and non-minority regions. Finally, we suggest to improve the willingness to engage in forest management and forestry industry development in minority regions through innovative management methods, concentrated and continuous large-scale management, en-couraging capital investment and driving forest landowners to "nearby employment", optimizing the logging quota system and raising the compensation standard for public welfare forests. This study has important practical significance for promoting the realization of forest ecological products value, consolidating the achievement of poverty alleviation in forest areas and realizing rural re-vitalization in China.
Conditionality of Visiting a Tourist Destination by the Degree of Environmental Risk and Attractiveness
Authors: Petrović Marko D. , Milovanović Ilija , Gajić Tamara , Kholina Veronika N. , Vujičić Miroslav , Blešić Ivana , Đoković Filip , Radovanović Milan M. , Čurčić Nina
Published: June 2023

In recent years, more and more attention has been paid to the behavior of tourists and their intention to travel after certain natural disasters or social unrest. The aim of the research was to establish the influence of psychological profiles of tourists on their decision to choose a tourist destination, using three psychographic techniques BFI-10 (Big Five Inventory), AIO (Activities, Interests, Opinions), and VALS 2 (Values and lifestyle), and a freely determined six-level scale of risk and tourist attractiveness of the imagined destinations. By analyzing the results through structural modeling-path analysis, it was determined that almost all psychographic orientations derived from lifestyles negatively perceive destinations with a high degree of risk and attractiveness, while with the VALS 2 technique, only members of the action orientation tend to accept the risk and challenge of visiting high-risk destinations. The results of the research have a degree of innovation in the application of the combination of the mentioned models, as well as in the theoretical and applied aspects in supplementing the building and strategic planning of the future business.
A Non-electrolysis Bioelectric Effect for Gingivitis and Hygiene Contamination Biofilm Removal
Authors: Kim Young Wook , Lee Jihyun , Han Sang Kuy , Koo Bon-Sang , Park Taeguen , Park Hyun Mok , Lee Byoungdoo
Published: June 2023

Bioelectric effect is known as combinatorial biofilm treatment with low dose of antibiotics with small electricity. When external electric field or current are applied, biofilms can be affected by the electrostatic force, non-uniform distribution of essential electrolytes, induction of low activity of enzyme, and increase of permeability of biofilms. In this work, we have focused on the reduction of applied electric power consumption that could avoid water electrolysis which was one of major challenges for biomedical applications. We have developed a new type of electrical signal that enhances the efficacy of biofilm removal. The results show combination of alternating and direct current remove biofilm effectively without causing electrolysis. We further developed an oral healthcare device as a bioelectric toothbrush and tested in dental clinic. The results demonstrated 75% reduction of gingivitis. In addition, we have tested a mimicked air conditioner biofilms that are root causes of aerobic hygiene infection. The result demonstrates 81.8% increased biofilm removal. In conclusion, a new bioelectric technology has been developed and demonstrated the biofilm removal efficacy without the electrolysis.
Vascular Dysfunctions Contribute to the Long-term Cognitive Deficits Following COVID-19
Authors: shabani zahra , Liu Jialing , su hua
Published: June 2023

As the name implies, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus and a member of the corona virus family, primarily affecting the upper respiratory system and the lungs. Like many other respiratory viruses, SARS-CoV-2 can spread to other organ systems. Apart from causing diarrhea, another most common but debilitating complication caused by the SARS-CoV-2 is neurological symptoms and cognitive difficulties, which occur in up to two thirds of hospitalized covid patients and ranging from shortness of concentration, overall declined cognitive speed to executive or memory function impairment. Neuro-cognitive dysfunction and “brain fog” are frequently present in COVID-19 cases, which can last several months after the infection, leading to disruption of daily life. Cumulative evidence suggests that SARS-CoV-2 affects vasculature in the extra pulmonary systems directly or indirectly, leading to impairment of endothelial function and even multi-organ damage. The post COVID-19 long-lasting neurocognitive impairments have not been studied fully; and the underlying mechanism remains elusive. In this review, we summarize the current understanding of the effects of COVID-19 on vascular dysfunction and how vascular dysfunction leads to cognitive impairment in patients.
Aroma Identification and Classification in 18 Kinds of Teas (Camellia sinensis) by Sensory Evaluation, Hs-Spme-Gc-Ims/Gc×gc-Ms, and Chemometrics
Authors: Lin Yanping , Yang Ping , Wang Ying , Huang Yibiao , Song Huanlu
Published: June 2023

Tea (Camellia sinensis) is one of the most popular beverages worldwide. Many types of tea prod-ucts continuously emerge in an endless stream; so, the classification or verification of tea be-comes more difficult. Aroma is a vital indicator of tea quality. The present study deals with the identification of aroma compounds in 18 different kinds of tea belonging to three typical tea va-rieties, including green tea, oolong tea, and black tea, using GC-IMS and GC×GC-O-MS. More-over, the clustering of all 18 tea samples and the in-depth correlation analysis between sensory evaluation and instrumental data were performed using the PCA and OPLS-DA. The results re-vealed that in all 18 kinds of tea, a total of 85 aroma compounds were detected by GC-IMS, whereas 318 were detected by GC×GC-O-MS. The PCA result revealed that green tea, oolong tea, and black tea could be clearly separated based on their peak areas. The OPLS-DA result showed that a total of 49 aroma compounds with VIP value > 1.0 could be considered as the potential in-dicators to quickly classify or verify tea types. This study not only compared the aroma differ-ences across different types of teas, but also provided ideas for the rapid monitoring of tea qual-ity and variety.
3D Bioprinting in Cardiovascular Disease: Current Status and Future Directions
Authors: Sun Zhonghua , Zhao Jack , Leung Emily , Flandes-Iparraguirre Maria , Vernon Michael , Silberstein Jenna , De-Juan-Pardo Elena M. , Jansen Shirley
Published: June 2023

3D printing is playing an important role in cardiovascular disease by use of personalised models with replication of normal anatomy and pathology with high accuracy and reliability. While 3D printed heart and vascular models are shown to improve medical education, preoperative planning and simulation of cardiac procedures, and enhance communication with patients, 3D bioprinting however, represents a potential advancement of 3D printing technology by printing cellular or biological components, functional tissues and organs that can be used in a variety of applications in cardiovascular disease. Recent advances in bioprinting technology have shown the ability to support vascularisation of large scale constructs with enhanced biocompatibility and structural stability, thus creating opportunities to replace damaged tissues or organs. In this review, we provide an overview of the use of 3D bioprinting in cardiovascular disease with a focus on technologies and applications in cardiac tissues, vascular constructs and grafts, heart valves and myocardium. Limitations and future research directions are highlighted.
Innovative Tools for the Nitrogen Fertilization Traceability of Organic Farming Products
Authors: Fabroni Simona , Bontempo Luana , Campanelli Gabriele , Canali Stefano , Montemurro Francesco
Published: June 2023

In the last decades, consumers are increasingly interested in organic products and they strongly demand for reliability of the traceability of the organic products they use to buy and eat. Different researches have been carried out over the years to investigate on new and reliable systems to test the authenticity of products obtained using organic cultivation methods. The monitoring of some chemical components, derived from primary and/or secondary metabolism, in horticultural organic and conventional products, has highlighted the diversity induced by the two production techniques while the difference in fertilization practices has been shown to impact on the isotopic distribution of some elements, with particular reference to nitrogen. An integrated system is proposed to validate, through the acquisition of isotopic data and other chemical and biochemical parameters, the authenticity of organic products. This approach is intended to be coupled to the application of chemometric multivariate analysis of isotopic data combined with other quality and nutraceutical parameters, giving the possibility to discriminate organic from conventional products, thanks to the different isotopic signature impressed by the different nitrogenous source combined with the qualitative pattern of the crops, significantly affected by the different treatments. The main perspectives of the presented integrated approach, based on the combined use of chemometric and analytical tools, are linked to the feasibility of applying a reliable system to authenticate productions obtained with organic fertilizers (organic agriculture) respect to those obtained with the use of synthetic fertilizers (conventional agriculture), protect and valorize virtuous farmers and support political stakeholders and decision makers to counteract food fraud.
Trademark Similarity Evaluation Using Combination of ViT and Local Features
Authors: Vesnin Dmitry , Levshun Dmitry , Chechulin Andrey
Published: June 2023

CNN-based off-the-shelf features have shown themselves as a good baseline for trademark retrieval. However, in recent years, the computer vision area was transitioning from CNNs to a new architecture – Vision Transformer. In this paper, we investigate the performance of off-the-shelf features extracted with vision transformers and explore the effects of pre, post-processing, and pre-training on big datasets. We propose a method of joint usage of global and local features, which leverages the best aspects of both approaches. Experimental results on METU Trademark Dataset show that off-the-shelf features extracted with ViT-based models outperform off-the-shelf features from CNN-based models. The proposed method achieves the mAP value of 31.23, surpassing previous state-of-the-art results. We assume that the proposed approach for the trademark similarity evaluation will allow one to improve the protection of such data with the help of artificial intelligence methods. Moreover, this approach will allow one to identify cases of unfair use of such data and form an evidence base for litigation.
An Overlooked Protein Domain, WIV, Is Found a Wide Number of Arthropod Viruses and Probably Facilitates Infection
Authors: Karlin David
Published: June 2023

Today, the most powerful approach to detect distant homologs of a protein is based on structure prediction and comparison. Yet this approach is still inapplicable to many viral proteins. Therefore, we developed a powerful sequence-based procedure to identify distant homologs of viral proteins. It relies on 3 main principles: 1) Traces of sequence similarity with a protein can persist beyond the significance cutoff of homology detection programs; 2) Candidate homologs can be identified among proteins with weak sequence similarity to the query, by using "contextual" information, e.g. taxonomy or type of host infected; 3) These candidate homologs can be validated using highly sensitive profile-profile comparison.As a test case, we applied our approach to a protein without known homologs, ORF4 of Lake Sinai virus (which infects bees). We discovered that ORF4 is composed of a domain that has homologs in proteins from >20 taxa of viruses infecting arthropods. We called it “Widespread, Intriguing, Versatile” (WIV) domain because it is found in proteins with a wide variety of domain organizations and functions. For example, WIV is encoded by the NSs protein of tospoviruses, a global threat to food security, which infect plants through arthropod vectors; by the protein encoded by RNA2 ORF1 of chronic bee paralysis virus, a widespread virus of bees; and by various proteins of cypoviruses, which infect the silkworm bombyx mori. WIV has a previously unknown structural fold, according to Alphafold predictions. In some viral species, WIV facilitates infection of arthropods, according to bibliographical evidence
Predicting the Effect of Mutations on Protein Stability and Binding: Assessment of Leading Algorithms Performance and Databases Content with Respect to Types of Mutations
Authors: Pandey Preeti , Pandey Shailesh , Rimal Prawin , Ancona Nicolas , Alexov Emil
Published: June 2023

Development of methods and algorithms to predict the effect of mutations on protein stability, protein-protein, and protein-DNA/RNA binding is necessitated by the needs of protein engineering and for understanding the molecular mechanism of disease-causing variants. The vast majority of the leading methods are either methods with adjustable parameters or machine learning algorithms, both requiring a database of experimentally measured folding and binding free energy changes. These databases are collections of experimental data taken from scientific investigations typically aimed at probing the role of particular residue on the above-mentioned thermodynamics characteristics, i.e., the mutations are not introduced at random and do not necessarily represent mutations originating from single nucleotide variant (SNV). Thus, the reported performance of the leading algorithms assessed on these databases or other limited cases, may not be applicable for predicting the effect of SNVs seen in the human population. Indeed, we demonstrate that the SNVs and non-SNVs are not equally presented in the corresponding databases and the distribution of the free energy changes are not the same. Furthermore, the Pearson correlation coefficients (PCCs) obtained on cases involving SNVs are less impressive than for non-SNVs, indicating that caution should be used in applying them to reveal the effect of human SNVs. All methods are found to underestimate the energy changes by roughly a factor of 2.
Methadone Maintenance and QT-interval: Prevalence and Risk Factors. Is it Effective to Switch Therapy to Levomethadone?
Authors: Santin Laura , Verlato Giuseppe , Tfaily Ahmad , Manera Roberto , Zinfollino Giuseppe , Fusina Francesca , Fabio Lugoboni
Published: June 2023

(1) Methadone is a chiral synthetic opioid primarily used to treat heroin and prescription-opioid addiction: the (R)-enantiomer (Levomethadone) activates the µ-opioid receptor more potently than the (S)-enantiomer, which is a more potent blocker of the hERG potassium channels, resulting in QTc prolongation. The purpose of this study is to assess the effect of methadone on the QTc interval and to investigate the benefits of Levomethadone. (2) The electrocardiograms of 165 patients taking methadone at various dosages and for different periods of time were examined: the QTc value was manually measured and then adjusted using Bazett's formula. (3) Data analysis revealed a linear association between the dosage of methadone and QTc length; no correlation was found between the QTc value and gender, age, or duration of therapy. 14% of the sample (23 patients) showed a prolongation of the QTc interval. 10 of the 23 patients with QTc elongation underwent a change of therapy from Methadone to Levomethadone: in 90% of these patients, a normalization in the QTc length was established. (4) This study confirmed the role of methadone, specifically its dosage, in QTc prolongation and the efficiency of Levomethadone as an adequate therapeutic substitute in these circumstances. This study validates the importance of a careful electrocardiographic monitoring in methadone-treated patients.
Impact of Dual-Energy Computed Tomography (DECT) Postprocessing Protocols in Detection of Monosodium Urate (MSU) Deposits in Foot Tendons of Cadavers
Authors: Klauser Andrea Sabine , Strobl Sylvia , Schwabl Christoph , Kremser Christian , Klotz Werner , Vasilevska Nikodinovska Violeta , Stofferin Hannes , Scharll Yannick , Halpern Ethan
Published: June 2023

Objective: To evaluate two different DECT postprocessing protocols for detection of MSU deposits in foot tendons of cadavers with verification by polarizing light microscopy as gold standard.Material and Methods: A total of 40 embalmed cadavers (15 male; 25 female; median age, 82 years; mean, 80 years; range, 52 - 99; SD ± 10.9) underwent DECT to assess MSU deposits in foot tendons.Two postprocessing DECT protocols with different Hounsfield unit (HU) thresholds 150/500 (=established) versus 120/500 (= modified) HU were applied to dual source acquisition with 80 kV for tube A and 140 kV for tube B.Six fresh cadavers (4 male; 2 female; median age, 78; mean, 78,5; range 61 - 95 ) were examined by DECT. Tendon dissection of 2/6 fresh cadavers with positive DECT 120 and negative DECT 150 studies were used to verify MSU deposits by polarizing light microscopy.Results: The tibialis anterior tendon was found positive in 57.5%/100% (DECT 150/120), peroneus tendon in 35%/100%, achilles tendon in 25%/90%, flexor halluces longus tendon in 10%/100%, and tibialis posterior tendon in 12.5%/97.5%. DECT 120 resulted in increased tendon MSU deposit detection, when DECT 150 was negative, with an overall agreement between DECT 150 and DECT 120 of 80 % (P = 0.013). Polarizing light microscope confirmed MSU deposits detected only by DECT 120 in tibialis anterior, achilles, flexor halluces longus and peroneal tendons.Conclusion: The DECT 120 protocol showed a higher sensitivity when compared to DECT 150.