bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-Crossing Anonymous MAPF for Tethered Robots
Authors: Peng Xiao , Simonin Olivier , Solnon Christine
Published: October 2023

This paper deals with the anonymous multi-agent path finding (MAPF) problem for a team of tethered robots. The goal is to find a set of non-crossing paths such that the makespan is minimal. A difficulty comes from the fact that a safety distance must be maintained between two robots when they pass through the same subpath, to avoid collisions and cable entanglements. Hence, robots must be synchronized and waiting times must be added when computing the makespan. We show that bounds can be efficiently computed by solving linear assignment problems. We introduce a variable neighborhood search method to improve upper bounds, and a Constraint Programming model to compute optimal solutions. We experimentally evaluate our approach on three different kinds of instances.
ADDRESSING NEW SOCIETAL EXPECTATIONS FOR HIGHER EDUCATIONAND ONLINE LEARNING IN THE POST-COVID-19 ERA
Authors: Sciabarrasi Leah
Published: October 2023

This article examines how people's lives and work environments have been altered as a result of technology, how these advancements have altered societal expectations for higher education, and three solutions for higher education institutions to address these new expectations. Firstly, to survive the new normal, higher education institutions must shift their student solutions and orientations to accommodate online learners. Secondly, faculty development must concentrate on training faculty to utilize online tools to teach. Thirdly,institutions must better prepare students to be savvy virtual collaborators through online learning and to translate these new skills to the workforce. Finally, this paper uses the lens of the COVID-19 pandemic to present three strategies for achieving these solutions.
Frida Pellegrino. 2020. The Urbanisation of the North-Western Provinces of the Roman Empire: A Juridical and Functional Approach to Town Life in Roman Gaul, Germania Inferior and Britain (Archaeopress Roman Archaeology 72). Oxford: Archaeopress; 978-1-7896-9774-2 paperback £48.
Authors: Rodríguez-Gutiérrez Oliva
Published: October 2023

 
La tetraléctica de la espacialidad: una propuesta de fundamentación teórica para el desarrollo del diseño autónomo territorial aplicado al urbanismo comunitario
Authors: Rivera Pabón Jorge Andrés
Published: October 2023

En el presente artículo de reflexión se expone la tetraléctica de la espacialidad como una propuesta de fundamentación teórica que orienta el estudio sobre la producción social de espacios urbanos incluyentes y participativos a través del diseño autónomo territorial, campo de conocimiento que se encuentra en un estado germinal, fruto de la reciente intersección entre el giro ontológico en el campo del diseño y el giro espacial en la teoría social crítica. Con este fin, se plantea como objetivo, realizar un análisis histórico de una serie de perspectivas epistemológicas y enfoques teórico-conceptuales que puedan aportar y enriquecer las bases discursivas del diseño autónomo territorial y las prácticas alternativas del “buen vivir” en ámbitos urbanos. En cuanto a la metodología empleada, se efectuó la revisión de la información documental, fotográfica e infográfica relevante para el cumplimiento del objetivo señalado. Entre los resultados enunciados, se explica el enfoque teórico propuesto y se presenta la indagación de algunas experiencias de acción colectiva que han sido pioneras a lo largo del tiempo en procesos de diseño urbano comunitario a nivel internacional, nacional y en la escala local de la ciudad de Manizales, Colombia. Por último, sobresale como conclusión que el diseño autónomo requiere de diferentes referencias teóricas y empíricas, por ello, es fundamental su conexión con múltiples expresiones de “diseños otros” territoriales que han ocurrido a lo largo de la historia, desde la ancestralidad de las comunidades pluriversales latinoamericanas hasta los movimientos sociales que han luchado por dignificar la vida colectiva en la ciudad.
Factores de diseño en el desuso prematuro de prendas de vestir: un enfoque desde las etapas de vida del producto
Authors: Ordóñez Suárez Daniela , Higuera Marín Miguel Enrique , Raigoza Díaz Carolina
Published: October 2023

La extensión de la vida útil o del tiempo de uso de las prendas de vestir es una forma de enfrentar el incremento del impacto ambiental en la industria de la moda, derivado de la aceleración en la demanda y el descarte de los productos. El objetivo de este estudio fue identificar las variables involucradas en el desuso prematuro de las prendas de vestir casuales con el fin de ser intervenidas por el diseño a lo largo de sus etapas. Esto, a través de un enfoque cualitativo en el que se aplicaron entrevistas a representantes de empresas y consumidoras de la ciudad de Bucaramanga y su área metropolitana, además de observaciones en los entornos de venta digitales de marcas nacionales. Lo anterior, con el fin de identificar las acciones y declaraciones de las marcas en torno a la durabilidad y su relación con los criterios de compra de las consumidoras, así como las motivaciones para la retención y el descarte de prendas de vestir. Los hallazgos muestran que el foco de los esfuerzos de las marcas se encuentra en la robustez de los materiales y la oferta de prendas atemporales basadas en el minimalismo, el uso de técnicas de producción manuales y artesanales, así como la construcción de una identidad estética de marca reconocible. Por su parte, la comodidad representó el principal criterio de compra, y de decisión de retener o descartar una prenda para las consumidoras, mientras que la calidad o robustez no presentó mayor influencia en estos escenarios. Estos resultados permiten visualizar oportunidades para la innovación mediante la aplicación del diseño, a partir de la empatía con el usuario.
Producciones tecnopopulares y hegemonía sociovisual en gráficas comerciales de Cotopaxi (Ecuador) y Tampico (México)
Authors: Naranjo Huera Vilma Lucía , Lozano Castro Rebeca Isadora
Published: October 2023

En los barrios de comercio popular de la provincia de Cotopaxi (Ecuador), así como en otros contextos de América Latina como Tampico (México), los pequeños comercios se promocionan con gráficas o carteles colocados en las fachadas de sus locales. El objetivo de este trabajo es discutir sobre las características de los diseños populares que identifican a estos pequeños negocios, desde la perspectiva del componente crítico de los diseños otros sudamericanos, y del debate teórico acerca de la cultura popular entendida como cultura subalterna. El análisis comparativo realizado entre gráficas identificativas de Cotopaxi y de Tampico permite examinar cómo los pequeños comerciantes actualizan sus carteles apropiándose de herramientas tecnológicas de edición gráfica, en tanto que se alejan del folclore de la rotulación manual. Como resultado de esta indagación, se establece una reflexión sobre el diseño tecnopopular que, a diferencia de las gráficas hegemónicas, crea e instala gráficas comerciales rotuladas a manera de carteleras tecnológicas, producto de la cultura urbano-rural cotopaxense; y se la contrasta con los diseños que fueron colonizados por la identidad hegemónica estadounidense en Tampico. Finalmente, este trabajo permite establecer un puente entre los diseños otros y lo diseñado desde los valores de la cultura popular. Y concluye que el reconocimiento de la nueva gráfica popular como parte del diseño es productivo, en tanto que permite reflexionar acerca de las visualidades diseñadas en el barrio, para el barrio.
6 Şubat 2023 Kahramanmaraş depremleri sonrası yeniden yapılanma sürecinde yere bağlılığın değerlendirilmesi: Antakya (Hatay) örneği
Authors: DİNÇ Yücel
Published: October 2023

Bu çalışmada, 6 Şubat 2023 Kahramanmaraş depremleri sonrasında Antakya kentinin yeniden yapılanması sürecindeki yere bağlılık durumu incelenmiştir. Depremler başta olmak üzere doğal afetler sonrasında oluşan yere bağlılık durumlarını ortaya koyan akademik çalışmaların oldukça sınırlı olması, bu çalışmanın hazırlanmasındaki başlıca motivasyonu oluşturmuştur. Nicel analiz yönteminin kullanıldığı çalışmada, depremler öncesinde Antakya’da ikamet etmiş olan 368 kişiye 30 sorudan oluşan anket uygulanmıştır. Katılımcıların anket sorularına verdikleri cevaplar SPSS yazılımı ile analiz edilmiş ve analiz sonuçları tablo ve grafiklerle ortaya konulmuştur. Ayrıca bazı sorulara verilen ifadelerden hareketle görsel analizler yapılmış ve bunun için MQXQUDA programından yararlanılmıştır. Çalışmanın bulgularına göre; katılımcıların % 82,1’i Antakya’yı özlediklerini, % 65,2’si Antakya’da olup bitenleri kesinlikle merak ettiklerini, % 82,6’sı Antakya’ya kök saldıklarını belirtmişlerdir. “Bundan sonra, Antakya’da yaşamaya devam edeceğim” ifadesine katılımcıların % 54,6’sı kesinlikle katılıyorum ve % 20,1’i katılıyorum cevabını vermiştir. Katılımcıların % 71’i Antakya’yı hiç terk etmeyen, sık sık veya belirli aralıklarla Antakya’yı ziyaret edenlerden oluşmaktadır. Başka bir değişle, katılımcıların % 71’i kentle bağlantısını sürdürmektedir. Katılımcıların % 73,1’i deprem sonrasında Antakya’ya hala çok bağlı olduklarını ifade etmişlerdir. Tüm bu istatistiksel sonuçlar, yaşanan depremlere rağmen yere bağlılığın güçlü olduğunu göstermiştir. Anket sonuçlarından farklı olarak, arazi gözlemleri neticesinde kentin sokaklarında yüksek bir aidiyet düzeyini yansıtan duvar yazılarının ve işyeri tabelalarının varlığı yere bağlılığın mekânsal yansımalarını oluşturmuştur.
The Moderating Role of Work-Family Conflict in The Effect of Perceived Social Support on Work and Life Satisfaction of Women Employees
Authors: GÖLPEK KARABABA Asiye , ÇELİK Mazlum
Published: October 2023

This research analyses perceived social support's moderating role on work-family life satisfaction and conflict among female employees during the pandemic (2020) in Gaziantep. Developed in industry and exports, Gaziantep has a high sector representation and employment rate. A survey was conducted in 3 companies with over 500 employees carrying out production/marketing activities in 4 different sectors to reach a sufficient sample size. The data obtained from 523 female employees were evaluated with SmartPLS programs, and the effect was observed. However, the moderator effect of the private friend dimension on both life satisfaction and job satisfaction could not be determined.
Finansal Gelişme Şoklarının Dalgacık Dönüşümü (Wavelet) ile Farklı Zaman Ölçeklerinde Analizi: MERCOSUR Ülkeleri Örneği
Authors: ERGÜN TATAR Havanur
Published: October 2023

Bu çalışmanın temel amacı, 1980-2020 dönemi yıllık verilerle MERCOSUR ülke grubunda finansal gelişme şoklarını analiz etmektir. Analizde, finansal gelişmeyi temsilen finansal gelişim endeksi (FD) ve onu oluşturan finansal kurumlar endeksi (FI) ile finansal piyasalar endeksleri (FM) kullanılmıştır. Dalgacık dönüşümü kullanılarak şokların kısa, orta ve uzun vadede kalıcı olup olmadığı sınanmıştır. Bu yönüyle çalışma literatüre önemli katkı sunmaktadır. Araştırma neticesinde orta vadede, incelenen tüm değişkenlerin karşılaştığı şokların geçici özellik taşıdığı tespit edilmiştir.
Türkiye Cumhuriyeti Vatandaşlarının Bağımsız Türk Dünyası Devletlerini Turizm Destinasyonu Olarak Algılama Düzeyleri
Authors: SARAÇ Ömer , KOÇOĞLU Cenk Murat , OKTAY Kutay , BATMAN Orhan
Published: October 2023

Bu araştırmanın amacı bağımsız Türk Dünyası devletlerinin destinasyon imajının belirlenmesidir. Araştırmada veriler anket tekniği ile elde edilmiş, kolayda örnekleme yöntemi uygulanarak Türkiye’deki 44 farklı ilden toplamda 679 örnekleme ulaşılmıştır. Elde edilen veriler istatistik paket programıyla analiz edilmiştir. Analizlere göre Türk Dünyası devletlerinin destinasyon imajı yüksek bir ortalamaya sahiptir. Güven boyutunun, destinasyon imajını oluşturan diğer tüm boyutlarla pozitif ilişkisinin en yüksek boyut olduğu belirlenmiştir. Özgün kültür ve çekicilik boyutunun ise algılama düzeyi en yüksek olan boyut olduğu tespit edilmiştir. Öte yandan daha önce Türk Dünyası devletlerini ziyaret eden turistlerin destinasyon algısı ortalamalarının, ziyaret etmeyenlere göre daha yüksek olduğu sonucuna ulaşılmıştır.
Sürdürülebilirlik Bağlamında G-20 Ülkelerinin Enerji Üretim Kaynaklarına Göre TOPSIS Yöntemiyle Sıralanması
Authors: MENTEN Cem , ÇEKİÇ Bülent
Published: October 2023

Bu çalışmada temel olarak, Çok Kriterli Karar Analizi (ÇKKA) teknikleri uygulanarak ülkeler düzeyinde farklı enerji üretim türlerine göre G20’ye üye ülkelerinin sıralanması amaçlanmaktadır. Bu çalışmada, literatürde sıkça kullanılan ÇKKA yaklaşımlarından biri olan TOPSIS yöntemi ile G20 ülkeleri enerji üretimlerine göre sıralanmıştır. G20’ye üye ülkeler alternatifleri; fosil yakıtlardan (petrol, doğalgaz ve kömür) elde edilen elektrik enerjisi, yenilenebilir enerji, nükleer enerji ve CO2 salınımı kriterleri oluşturmaktadır. 2020-2022 yılları arasında her yıl için G20 ülkeleri farklı enerji üretim tiplerine göre iki farklı senaryo altında değerlendirilmiştir. Tüm kriterlerin eşit ağırlığa sahip olduğu ilk senaryoda değerlendirme altındaki yıllarda her yıl için sırasıyla Amerika Birleşik Devletleri (ABD), Avrupa Birliği (AB) ve Çin en üst sırada yer almıştır. Kriter ağırlıklandırılmasına yönelik çevresel perspektife sahip ikinci senaryoda ise, ilk senaryoya benzer şekilde AB ve ABD ilk iki sırada yer alırken, Fransa sıralamada üçüncü ülke konumundadır. Çalışma kapsamında elde edilen en dikkat çekici bulgu, ilk senaryoda üst sıralarda yer alan Çin ve Suudi Arabistan’ın, çevresel bakış açısı ile değerlendirilen ikinci senaryoda son sıralarda yer almasıdır. Literatürde yer alan çalışmalardan farklı olarak, bu çalışmada yenilenebilir enerji üretimi, nükleer enerji üretimi ve emisyon değerlerinden oluşan kriterlere daha yüksek ağırlıklar atanarak çevreci bir bakış açısı ile değerlendirmelerde bulunulmuştur.
Sosyal Bilimlerde Dijitalleşme ve Sosyal Bilgiler Öğretim Programına Yansıtılması
Authors: ESKİCİ Ebru , ALTUN Adnan
Published: October 2023

Sosyal bilgiler öğretim programının çekirdek yapısını oluşturan sosyal bilim dalları, dijitalleşme ve dijital dönüşümün etkisiyle kuramsal, kavramsal ve yöntemsel birçok değişiklik yaşamaktadır. Bu durum sosyal bilimlere ait bilgi, beceri ve değerlerin öğrencilere kazandırılmasında etkin bir rol oynayan sosyal bilgiler öğretim programını etkilenmektedir. Sosyal bilgiler öğretim programı (2018) incelendiğinde programda yer alan kazanım, beceri ve değerlerin ağırlıklı olarak teknolojik ürün temelli olduğunu söylemek mümkündür. Bu durum sosyal bilim dallarında yeni üretilen bilgilerin, dijital çağın gerektirdiği beceri ve değerlerin programa yeterince yansıtılmadığını göstermektedir. Bu araştırma ile dijital çağın gerektirdiği, bilgi, beceri ve değerlerin tespit edilerek sosyal bilgiler öğretim programına yansıtılması amaçlanmaktadır. Betimsel temelli nitel araştırma modeline göre yürütülen bu araştırmada öncelikle sosyal bilim dallarında dijitalleşme ve dijital dönüşümün etkisiyle meydana gelen değişimler ve dönüşümler tespit edilmiş, ardından sosyal bilgiler öğretim programı ile ilişkilendirmeleri yapılmıştır. Doküman incelemesine dayalı olarak toplanan araştırma verilerini 2018-2020 yılları arasında, sosyal bilimler alanında dijitalleşme ve dijital dönüşüm bağlamında yapılmış 8261 akademik çalışma oluşturmaktadır. Web of Science ve DergiPark veri tabanlarından elde edilen akademik çalışmalar bibliyometrik analiz yöntemi ile incelenmiştir. Analizler sonucunda sosyal bilimlerde dijitalleşme ve dijital dönüşümle ortaya çıkan konu alanları ile ilgili kavramsal bir yapı oluşturulmuştur. Oluşturulan bu kavramsal yapı temel çerçeve kabul edilerek sosyal bilgiler öğretim programında dijital çağın gereksinimlerine yönelik olarak her sınıf düzeyinde kazanım, kavram, beceri ve değer ilişkilendirmesi yapılmıştır. Böylece sosyal bilgiler öğretim programının dijital çağın taleplerini karşılayabilecek niteliğe erişmesinde ilerleme kaydedileceği düşünülmektedir.
Decision-making support system for beef cattle carcass quality using fuzzy modeling
Authors: Silva Allan Leon Casemiro da , Gabriel Camila Pires Cremasco , Putti Fernando Ferrari , Chacur Marcelo George Mungai , Gabriel Filho Luís Roberto Almeida
Published: October 2023

Carcass assessment by slaughterhouses is as important as an efficient production of quality animal. The evaluation is performed subjectively by individuals although it follows delimited criteria. Therefore, an expert system should be developed to allow both reduction of subjectivity in analysis and valuation with more complex and non-continuous variables. This chapter aimed at developing a decision-making support system to assess beef cattle carcass in slaughterhouses, using a fuzzy logic modeling. The subjective knowledge of experts on beef cattle carcasses quality was used to build membership functions. Animal maturity, weight, and fatness degree were used as quality indicators, but quality itself was an output variable. The proposed fuzzy model showed 89.5% compatibility with the scores of the experts and allowed a higher specificity of the presented score, reducing differences between classifications.
The mechanism of high mobility group box-1 protein and its bidirectional regulation in tumors
Authors: Tian Zhongjia , Zhu Lin , Xie Yutong , Hu Huan , Ren Qunli , Liu Jianguo , Wang Qian
Published: October 2023

High-mobility group box-1 protein (HMGB1) is a nonhistone chromatin-related protein widely found in eukaryotic cells. It is involved in the transcription, replication, and repair of DNA to maintain nuclear homeostasis. It participates in cell growth, differentiation, and signal transduction. Recent studies showed that HMGB1 has a bidirectional regulatory effect on tumors by regulating TLR4/MYD88/NF-κB and RAGE/AMPK/mTOR signaling pathways. On the one hand, it is highly expressed in a variety of tumors, promoting tumor proliferation and invasion, while on the other hand, it induces autophagy and apoptosis of tumor cells and stimulates tumor-infiltrating lymphocytes to produce an anti-tumor immune response. At present, HMGB1 could be used as a target to regulate the drug resistance and prognostication in cancer. Clinical applications of HMGB1 in cancer need further in-depth studies.
Investigating polymorphisms in genes encoding TGF-β1, IL-10, and IL-6 and their associations with type 1 diabetes mellitus
Authors: Ahmed H Alghamdi , Mohamed F El-Refaei , Ibrahim M Shatla , Sherif M El-Sherbini
Published: October 2023

Many cytokines play a role in the pathogenesis of Type 1 Diabetes (T1D), and gene polymorphisms could possibly contribute to the disease’s genetic predisposition because they can affect cytokine production or function. The purpose of this study was to investigate the role of the gene polymorphisms TGF-β1 (+869T/C), (+915G/C), IL-10 {-1082 G/A), (-819 C/T), and (-592 A/C), and IL-6 (-174 G/C) in hereditary vulnerability to T1D. The Polymerase Chain Reaction with Sequence-Specific Primers (PCR-SSP) was used to analyze the polymorphisms. According to their genotypes, individuals were divided into the low-, high-, or intermediate-producer phenotypes predicted for these cytokines polymorphisms. Our findings revealed that the production of TGF-β1 was significantly higher in control than in T1D participants whereas the IL-6 genotype with low IL-6 production was significantly increased in the cases compared to the control. A significant association was evident between TGF-β1 and IL-6 low production and the incidence of T1D, thereby confirming the importance of TGF-β1 and IL-6 polymorphism as a genetic factor contributing to the incidence of T1D. By contrast, the involvement of IL-10 in the incidence of T1D was not as clear. Although some evidence supports a relationship, no statistically significant association has been verified between IL-10 and T1D. This type of measurement could be beneficial in determining the susceptibility and severity of the T1D condition while also taking into consideration the prediction of T1D incidence.
Introducing GolgiTAG to Cells and Immunoprecipitation of Golgi v2
Authors: Y. Fasimoye Rotimi
Published: October 2023

Golgi apparatus is essential to the secretory pathway of the cell and by extension helps to maintain cellular homeostasis. It is the main transportation hub of the cell, where molecules destined for other organelles within the cytoplasm or outside the cell for secretion are packaged into vesicles. The purification of Golgi using available techniques is time-consuming and laborious, as it requires various centrifugation steps, sometimes in gradient buffers, which reduce yield, compromise its integrity, and increase the chance of contamination, especially from endoplasmic reticulum. Furthermore, depending on the cell type or tissue, the methods for Golgi purification differs. Here, we present a protocol for rapidly purifying Golgi from the mammalian HEK293 cell line, using high affinity anti-HA magnetic beads. This method relies on the immunoprecipitation, in phosphate buffer, of HA-tagged integral membrane protein of the Golgi complex, TMEM115. The HA-tagged TMEM115 expressing vector is packaged into a lentivirus, therefore various mammalian cell lines can be transduced, giving stable expression levels. Our protocol is fast, approximately 10 min, and can be used on various cell lines and tissues without any modification. The Golgi purified using this method are highly enriched, intact, contaminant-free and, depending on solubilisation buffer, could be used for various downstream applications, such as proteomics and metabolomics. In this new version, the last step contains a supplemental video with extra context and tips, as part of the ASAP Protocol Particulars, featuring conversations with protocol authors
Cryo-EM sample preparation for full length LRRK2(I2020T):MLi-2/GZD-824-E11 DARPin complex v1
Authors: Sanz Murillo Marta , Villagran Suarez Amalia
Published: October 2023

Guide for cryo-EM grid preparation of FL-LRRK2 bound to Type-I/Type-II inhibitors
ESTRATÉGIAS PARA REFLEXÃO E CONHECIMENTO COMPARTILHADO COM ADOLESCENTES SOBRE SAÚDE SEXUAL E REPRODUTIVA
Authors: Aragao Herifrania , Barbosa dos Santos Magna Kelly , Dos Santos Cavalcante Caline , Tawanne Santana Jéssy , Moura de Melo Cláudia
Published: October 2023

O objetivo foi relatar a experiência do conhecimento compartilhado dos facilitadores do Núcleo de Ensino Básico (NEB) com adolescentes da Rede Educacional Pública de Sergipe, a partir da realização de oficinas temáticas sobre saúde sexual e reprodutiva. Foram realizados três encontros sequenciais, por grupo formado, de oficinas temáticas, aos 250 adolescentes, para discutir Sexualidade, Infecções Sexualmente Transmissíveis, gravidez e Zika vírus. Aplicou-se questionário como feedback das oficinas (pré/pós intervenção), cujos dados foram analisados pelo software SSPS, 25.0. Observou-se que as ações, associadas aos comentários positivos, obtiveram significativas melhorias no conhecimento pós-intervenção (p<0,05), além da redução de anseios e tabus. Conclui-se a importância do lúdico e a atividade de extensão universitária para socialização e compartilhamento de saberes junto à comunidade, de forma interdisciplinar.
SORVETE SABOR MANGABA (Hancornia Speciosa Gomes) ADICIONADO DE FARINHA DA CASCA DO MARACUJÁ (Passiflora Edulis)
Authors: Barbosa João Batista , Dos Santos Silva Daniel , Vilela Talma Simone , Maurício Furtado Martins Eliane , Lima Balieiro Acenini , Hojo Rebouças Karine , Lopes Martins Maurilio
Published: October 2023

Este trabalho objetivou desenvolver e avaliar a qualidade de sorvete sabor mangaba adicionado de farinha da casca de maracujá (FCM). As amostras foram identificadas de acordo com a concentração de farinha em A: 0,0% FCM, B: 1,0% FCM e C: 2,0% FCM. Foram realizadas análises microbiológicas de presença/ausência de Salmonella sp., contagem de fungos filamentosos e leveduras, contagem de coliformes totais e coliformes termotolerantes, análises de overrun, análises físico químicas de pH, acidez, gordura, extrato seco total (EST), extrato seco desengordurado (ESD) e umidade, além de análise sensorial. Os sorvetes apresentaram ausência de Salmonella sp. em 25g, <3,0 NMP/g de coliformes totais e termotolerantes e < 2,5 x 102 de fungos filamentosos e leveduras. Houve diferença (p<0,05) de pH, acidez,  gordura, extrato seco total (EST) e umidade entre as amostras de sorvete contendo farinha da casca de maracujá. As formulações contendo com 0,0 % (A) e 1,0 % (B) de farinha apresentaram maiores médias para a impressão global do sorvete (p<0,05), estando entre gostei moderadamente e gostei muito na escala hedônica de nove pontos. Alguns ajustes podem ser realizados a fim de tornar o sorvete mais aceito pelos consumidores. A adição de farinha de casca de maracujá ao sorvete de mangaba torna o produto promissor, sendo uma alternativa inovadora de produto lácteo na região do Alto Sertão de Sergipe.
ANALYSIS OF THE FUNCTIONING OF THE NATO ANALYTICAL INTELLIGENCE SYSTEM
Authors:   Odesa Military academy, Maksimenko Yu.A. , Mamich V.V. ,   Odesa Military academy, Popov S.A. ,   Odesa Military academy, Sharshatkin D.Yu. ,   Odesa Military academy
Published: October 2023

For the successful conduct of a modern battle, according to the views of modern military scientists, it is necessary, first of all, to know the enemy, his forces, means and nature of actions. In order to provide commanders and staffs of all levels with this data, there is the most important type of combat support for military operations - intelligence. The experience of conducting military operations shows that only where reconnaissance is conducted actively and purposefully, combat tasks are solved successfully and with the least losses. On the contrary, poorly organized intelligence has always been the main cause of unsuccessful military operations. Nowadays, the volume of tasks solved by intelligence has grown significantly. Instead, the terms of their implementation were significantly reduced. The requirements for the time of data transmission and the accuracy of determining the coordinates of enemy objects (targets) have increased. Analytical intelligence is a component of intelligence activity, consisting of detection, assessment, forecasting of various social processes, events, activities based on information, mainly obtained from open sources, as well as obtained by intelligence of other types (agency, technical, etc.). Analytical intelligence is divided into operational (which serves current needs) and strategic (which forms stable insights). Proactively investigates short-term phenomena (occurring, recent or soon expected) to ensure appropriate immediate action. Strategic reveals what is extremely unobvious, does not come soon, changes slowly, requires long-term, large-scale measures. Aspects of analytical intelligence: collection and comparison of various information in order to identify trends, contradictions, misinformation, misinterpretation, manipulative measures, implicit events, hidden activities, as well as the formation of general ideas about various significant subjects and phenomena; assessment of subjects, events, actions, intentions; forecasting events, actions, intentions; planning of activities, events. Information provision of specific open and secret operations; participation in the development of strategies for ensuring national security, national development, and global development. Wide implementation of modern information technologies has become an urgent issue today, according to scientists, it is an absolute requirement of modern warfare.
Functions of the Constitution of the Russian Federation
Authors: Narutto S. V.
Published: October 2023

The paper analyzes the opinions of researchers concerning the concept and types of functions of the Constitution of the Russian Federation and their features. The author explains her approach to the classification of the functions of the Constitution. The paper considers the content of the functions of the Constitution and their dynamism, taking into account the change of ideals and priorities in the State and society. Special attention is paid to the specific function of the Constitution — the constituent one. The author raises the question of whether it is possible to assert that the norms-principles of the Constitution have their own functions, since they define an ideal basic model of relations that is implemented through concrete actions. It is concluded that the regulatory and protective functions will be revealed through regulations specifying and detailing these principles. The author explains the ideological function of the Constitution that determines the moral and value patterns of human behavior, the authorities’ activities. All values enshrined in the Constitution find their expression in the ideological function of the Constitution.
Development of Public Power in Judicial Acts and Legal Positions of the Constitutional Court of the Russian Federation: To the 30th Anniversary of the Constitution of the Russian Federation
Authors: Ivanov I. V.
Published: October 2023

The paper analyzes the main legal positions of the Constitutional Court of the Russian Federation since the 1990s until 2023 on the organization and functioning of public authority in Russia in the context of the theory of the «living» Constitution of Russia. To expand on the topic the author dwells upon the legal positions of the constitutional control body as an explanation of the norms of the Russian Constitution, which influences the law-making process and law enforcement practice. Based on the analysis of judicial acts, the main constitutional characteristics of public power are determined: inclusion of municipal government in its composition (the presence of organizational isolation of local government bodies with their functional unity with state power); continuous functioning and historical succession of public power; exercise of public power at the level of the Federation, constituent entities of the Federation, municipalities with the inadmissibility of violating each other’s competence by these levels. It is noted that the main task of state building may be to bring the activities of public authorities closer to the forms of democracy, as well as the development of their direct connections through public discussions between public authorities and the people, society, and citizens.
Characterization of Focal Mechanisms for Upper Crustal Distributed Seismicity in Aotearoa New Zealand
Authors: Thingbaijam Kiran Kumar Singh , Rattenbury Mark S. , Van Dissen Russ J. , Gerstenberger Matt C. , Ristau John , Fitzenz Delphine D.
Published: October 2023

Applying distributed seismicity models for seismic hazard analysis requires postulating the styles of faulting and nodal planes for anticipated earthquakes. Here, we present a model describing focal mechanisms, or more specifically, strike, dip, and rake angles, for the ruptures of shallow (hypocentral depth ≤40 km) crustal earthquakes in Aotearoa New Zealand. This model is based on delineations of neotectonic domains and analysis of pre-existing datasets, including an active fault database, geological map-based fault datasets, the New Zealand Community Fault Model, and a regional moment tensor catalog. We demonstrate that the focal mechanism model is broadly consistent with the regional moment tensor catalog, with respect to spatial distributions of P and T axes and in terms of the Kagan angle. This characterization of focal mechanisms complements the distributed seismicity component of the New Zealand National Seismic Hazard Model 2022.
Perfil Epidemiológico da Leptospirose no Estado do Amapá
Authors: Almeida Rivelton , Santos da Silva Gabriel , Thynally Serrão Barbosa Karollyne , Silva Josy Janne Lopes da
Published: October 2023

Resumo
A leptospirose é uma doença infecciosa febril transmitida por roedores através do contato direto ou indireto com urina, comumente propagada em aglomerados urbanos com acúmulo de lixo, inundações, alagamentos e infraestruturas de saneamento precárias. Este estudo teve como objetivo identificar o perfil epidemiológico da leptospirose no estado do Amapá durante o período de 2013 a 2022. Foi realizado um estudo descritivo e retrospectivo com dados disponibilizados pelo Sistema de Informações de Agravos de Notificações (SINAN) e pelo boletim epidemiológico da Superintendência de Vigilância em Saúde do Amapá (SVS/AP). Foram analisados a prevalência da leptospirose e variáveis epidemiológicas como localidade de infecção, faixa etária, sexo e escolaridade no período proposto. Os resultados mostraram uma prevalência de 6,6 casos a cada 100.000 habitantes nos 10 anos avaliados, com destaque para os anos de 2016 e 2018 com 10.1 e 9,2 casos a cada 100.000 habitantes, respectivamente. O perfil epidemiológico encontrado indicou que a doença afetou principalmente homens com idade de 20 a 59 anos, residentes em Macapá, com escolaridade de ensino fundamental incompleto, notificados nos meses de fevereiro a maio. Estes resultados evidenciam a vulnerabilidade das populações de risco à doença, o que sugere a necessidade de um maior incentivo em programas de controle e monitoramento epidemiológico.
Palavras-chave: Leptospirose. Epidemiologia. Leptospira spp. Amapá.  
Abstract
Leptospirosis is a febrile infectious disease transmitted by rodents through direct or indirect contact with urine. It is commonly spread in urban clusters with garbage accumulation, flooding, poor sanitation infrastructure. The aim of this study was to identify the epidemiological profile of leptospirosis in the state of Amapá during the period from 2013 to 2022. A descriptive and retrospective study was conducted using data available from the Information System for Notifiable Diseases (SINAN) and the epidemiological bulletin of the Amapá State Health Surveillance Superintendence (SVS/AP). The prevalence of leptospirosis and epidemiological variables such as location of infection, age range, sex, and education were analyzed during the proposed period. The results showed a prevalence of 6.6 cases per 100,000 inhabitants in the 10-year period evaluated, with highlights in 2016 and 2018, with 10.1 and 9.2 cases per 100,000 inhabitants, respectively. The epidemiological profile found indicated that the disease mainly affected men aged 20 to 59 years, living in Macapá, with incomplete primary education. These results highlight the vulnerability of at-risk populations to the disease, suggesting the need for greater encouragement in programs for control and epidemiological monitoring.
Keywords: Leptospirosis. Epidemiology. Leptospira spp. Amapá.
Clinical evaluation and accuracy of mechanical axis alignment in robotic total knee arthroplasty
Authors: Lychagin A. V. , Gritsyuk A. A. , Rukin Ya. A. , Elizarov M. P. , Gritsyuk A. A. , Gavlovsky M. Ya. , Bogatov T. V.
Published: October 2023

The first experience in robotic total knee arthroplasty (RoTKA) has been obtained resulting in the questions about clinical efficiency and accuracy of lower limb alignment.

Objective To clarify clinical evaluation and accuracy of alignment of the mechanical axis of the lower limb in RoTKA.

Materials and methods Twenty-nine patients with osteoarthritis of the knee of Kellgren-Lawrence stage 3-4 underwent RoTKA. The knee joint was assessed with VAS, WOMAC, FJS-12; the range of motion was measured. The changes in the axis of the lower limb were evaluated on the full limb length radiographs.

Results Pain before the surgery according to VAS was 5.8 ± 1.5 points, on the first day after the surgery it was 8.5 ± 1.4, on day 3 – 5.9 ± 1.2, on day 12 – 2.9 ± 1.1. The range of motion on the first day after the surgery was 99.5° ± 1.4°, three months later – 115.1° ± 1.1°, six months later – 125.6 ± 1.5°, one year later– 127.5 ± 1.6°. The WOMAC score before the surgery was 32.7 ± 3.3, after the surgery 25.1 ± 2.1, three months later 7.3 ± 1.3, six months later 2.8 ± 0.2, and after one year – 1.3 ± 0.5. The FJS-12 score 3 months after the surgery was 68.2 ± 4.1, after 6 months 80.3 ± 2.9, after one year 94.0 ± 2.1. The analysis of postoperative full length roentgenograms in 72 % of cases (n = 21) did not reveal any deviation of the mechanical axis from the planned one and in 28 % of cases (n = 8) the deviation of the mechanical axis was up to 1° from the planned one.

Discussion Neither technical difficulties nor complications inherent to RoTKA were found. According to the results of VAS, WOMAC and FJS‑12 questionnaires, and the assessment of the range of motion, a positive dynamics was observed. According to the results of tele-roentgenograms, there was alignment of the limb axis and the accuracy of the position of the endoprosthesis components.

Conclusion The study of this technology has demonstrated safety, accuracy of alignment of the mechanical axis, validity of indications and contraindications, and stable early clinical results.
Clinical profile and laboratory parameters of febrile seizures: a hospital based cross-sectional study in sub-Himalayan region
Authors: Lajeo Kaikho , Sharma Rakesh , Kumar Pancham
Published: October 2023

Background: Febrile seizures occur commonly in the age group of 6 to 60 months, clinical spectrum is variable and range from single, brief episode to status epilepticus which can further progress to long term consequences. There is very limited data available from sub-Himalayan belt of northern India, hence the present study was planned to know the clinical spectrum, pattern of lab parameters and their association as a risk factor for occurrence of seizures.
Methods: A hospital based cross-sectional study was conducted in the department of paediatrics of Indira Gandhi Medical college, Shimla, Himachal Pradesh. All children between 6 to 60 months admitted in our institute during the study period of July 2021 to June 2022 with diagnosis of febrile seizure were considered for the study.
Results: A total of 120 children were included in the present study with a mean age of 26.6±14.2 months. Majority of the study subjects were from rural area (74.2%) and male had slightly higher representation (55.8%). Generalised tonic-clonic seizure (78.3%) was the most common phenotypic presentation, cases with SFS constituted 61.7% and CFS was observed in 38.3% of study subjects. Raised ESR values, elevated CRP values and leucocytosis had significant association in occurrence of CFS.
Conclusions: The study provides valuable insights into the different phenotypic presentations and characteristics of febrile seizures in the study population. The study further identifies a statistically significant association between certain inflammatory markers and CFS.
Barriers to exclusive breastfeeding in first 6 months of life in infants born in a tertiary care center in Hyderabad
Authors: Ali Syed Adnan , Lakshmi C. V. S. , Mirza Numeera A. , Siddiqui Shariq , Anis Heeba , Manfusa Hunaina
Published: October 2023

Background: Exclusive breast feeding during first 6-months has been proven to ensure growth and development of children. The habit of Exclusive breast feeding is often overlooked by mothers due to various factors. Therefore, this study aims to identify the barriers to Exclusive Breast Feeding.
Methods: This is a prospective study conducted from August 2018 to October 2020 in a tertiary care hospital in Hyderabad among 155 mothers with neonate to 6 months old infants. Data was collected through face-to-face interview using premade questionnaire and a predetermined sample size of 155 was considered.
Results: The prevalence of exclusive breast feeding was 20%. The barriers to exclusive breastfeeding practice were identified as lower socio-economic status (59.4%), Lack of formal education (52.9%), lack of counselling about breast feeding (10.3%), early return to work (32.2%), poor family support (49.03%), 22-25years mean age group (36.7%) , use of bottle feeding (16.3%) and pacifiers (12.2%). It was also observed that mothers experienced difficulties such as cracks (2.58%) and suction problems (2.58%) currently, and breast pain (2.58%) previously.
Conclusions: Promoting education of women especially in lower socio-economic sector and emphasizing need of avoiding complementary feeding rather counselling women regarding importance of exclusive breastfeeding during first 6-months and negative impact of early return to work, and providing health care for the difficulties faced during breastfeeding and encouraging family support are recommendations to improve exclusive breastfeeding practice.
Glycemic control versus quality of life in a cohort of diabetic children from South Kerala
Authors: Dhanya  , Cherian Carol Sara , Abraham Jacob
Published: October 2023

Background: Assessment of HRQOL (Health related quality of life) in clinical practice is important to determine the course of the disease, early recognition of problems and the type of insulin therapy that would be adequate to maintain satisfactory metabolic control with less impact on HRQOL in every patient.
Methods: A cross-sectional analytical study was conducted in the tertiary care hospital in Kerala. All children’s who aged 4-18 years with type 1 diabetes mellitus (DM) attending pediatric OPD in a tertiary care hospital in Kerala were included. The study period was 18 months. PedsQL diabetes module 3.0 (pediatric quality of life inventory 3.0 diabetes module) and PedsQL generic core module 4 (pediatric quality of life inventory 4.0 generic core scale) were used as tools.
Results: The study population included 30 children with type 1 DM. The average duration of diabetes was 5.60±2.990 years.  Based on HbA1c level, 16 [53.3%] children had well controlled diabetes and 14 [46.7%] had poorly controlled diabetes. Eighteen [80%] patients had complications in the form diabetic ketoacidosis or hypoglycemia in the past 1 year. Diabetes specific quality of life mean scores were [child report and parent proxy report] 88.4 and 85.9 for poorly controlled diabetes group and 94.4 and 93.0 for well controlled group respectively which showed a significant difference (p value 0.004). Children with better glycemic control also showed better generic score (p value-0.004).
Conclusions: Metabolic control, measured by HbA1c value, was significantly associated with QoL in patients with diabetes. Good glycemic control is associated with better quality of life and less diabetes related symptoms.
Cross sectional study of risk factors, clinical and bacteriological profile of neonatal sepsis in tertiarty care hospital
Authors: Shetty Shifali , Basavaraj  , K. Pushpalatah
Published: October 2023

Background: The neonatal period is the most vulnerable time for a child's survival. Neonatal sepsis contributes substantially to neonatal morbidity and mortality and is an ongoing major global public health challenge. Signs and symptoms of infection in neonates are subtle and non-specific hence further research is needed to identify a biomarker with high diagnostic accuracy and validity.
Methods: This was a descriptive cross sectional study conducted in the department of paediatrics ESICMC and PGIMSR from March 2021 to August 2022.
Results: In this study there were total of 130 neonates, of whom 78 were male. 82 (63.1%) newborns were premature and prematurity emerged to be the most common risk factor followed by LBW (53.8%), maternal gestational diabetes (24.6%) and MSL (22.3%). Majority of the newborn had EOS 63.1%. The most common presenting feature was lethargy, respiratory distress and feed intolerance. Blood culture positivity rate was 23.1%. The most common organism isolated was Klebsiella pneumonia. Mortality in the study was 9.2% (n=12).
Conclusions: Early diagnosis and treatment is of paramount importance to prevent mortality. High index of suspicion is required to detect sepsis at earliest. Prematurity, low birth weight, prolonged rupture of membranes, MSL are major risk factors predisposing neonate to sepsis. Gram negative organism like Klebsiella and E. coli are the common causative organism in neonatal sepsis.
The effectiveness of age based empowerment program on knowledge and attitude regarding risk taking behaviour and its prevention among adolescents studying in selected PU colleges of Vijayapur
Authors: Varghese Aleyamma , Kamble Anita , K. Kavitha , Desai Shrikant
Published: October 2023

Background: Adolescence involves personal growth. Several risk-taking behaviour occur at this vital time. A practise that is dangerous for an early teen may not be harmful for a late adolescent. This time period has various developmental features. Risky activity may be socially acceptable depending on its type, frequency, and level. Furthermore, empirical data reveals that young individuals are more prone to participate in dangerous behaviour with catastrophic and long-term repercussions.
Methods: A pre-experimental study was conducted among 120 adolescents at selected PU College of Vijaypura District, Karnataka. Study participants were selected by convenient sampling technique, and data were collected using pre-tested, structured questionnaires. The data was analysed using descriptive and inferential statistics.
Results: None of 120 individuals understood risk-taking and its prevention in the pre-test, whereas 87.5% (Sufficient knowledge) and 12.5% (Adequate knowledge) did post-test. After the post-test, attitudes were 53.3% negative and 46.7% positive, with a p<0.05% (t=62.21) and a significant threshold of 0.05. Knowledge was increased to 80.21% from difference mean pertest 3.74 to 18.7 mean post-test. The mean pretest and post-test attitude scores were 28.5 and 28.4, respectively. Difference was negligible and non-significant. Age-based empowerment programming efficacy on teenage risk-taking behaviour is 0.05. Some demographics did not affect pretest knowledge, but gender did.
Conclusions: Risk-taking is a global issue that worries individuals and communities. Adolescents are often unaware of their risky activity. Many took risks owing to poverty, lack of parental supervision, peer pressure, and enjoyment. However, competent counselling can address dangerous behaviour.
A rare case of congenital nasopharyngeal teratoma causing airway obstruction in the newborn
Authors: Rekha  , Guleria Munish , Meena Jitendra Kumar , Ahuja Arvind , Singh Neha , Richa
Published: October 2023

Teratomas are the most common congenital tumors, but teratomas of the nasopharynx are rare in neonates. The present report is about 23 days new born with a nasopharyngeal teratoma protruding from the oral cavity. The mass lesion nearly total obstructed the airways and demand immediate intervention. The nasopharyngeal mass was successfully excised by the transpalatal route. Histological examination showed that it was a mature teratoma. Although nasopharyngeal teratoma is a benign tumor, it may lead to urgency of airway management in the newborn. In this rare case presentation, the differential diagnosis and treatment of nasopharyngeal teratoma has been discussed in accompaniment with the literature information.
Successful management of neonatal gastric perforation in Tripura medical college and Dr. BRAM teaching hospital-a rare case report
Authors: Basak Aniruddha , Dey Niladri Sekhar , Dhar Sathi
Published: October 2023

Gastric perforation in the newborn is a rare surgical emergency in our practice area; nevertheless, since the earlier it is diagnosed, the better the prognosis, it is a possibility that we must be aware of. Perforation would be suspected in an infant with severe abdominal distension and diagnosis is confirmed with simple abdominal X-rays, including anteroposterior and lateral projections with horizontal ray, on which pneumoperitoneum will be shown. We report the case of a neonate diagnosed with gastric perforation at 72 hours of age who underwent a successful surgical intervention and was able to go home clinically healthy 14 days later.