bluuebunny/crossref_metadata_2025 huggingface dataset:
Antioxidant Synergy of Mitochondrial Phospholipase PNPLA8/iPLA2γ with Fatty Acid–Conducting SLC25 Gene Family Transporters
Authors: Jabůrek Martin , Průchová Pavla , Holendová Blanka , Galkin Alexander , Ježek Petr
Published: April 2021

Patatin-like phospholipase domain-containing protein PNPLA8, also termed Ca2+-independent phospholipase A2γ (iPLA2γ), is addressed to the mitochondrial matrix (or peroxisomes), where it may manifest its unique activity to cleave phospholipid side-chains from both sn-1 and sn-2 positions, consequently releasing either saturated or unsaturated fatty acids (FAs), including oxidized FAs. Moreover, iPLA2γ is directly stimulated by H2O2 and, hence, is activated by redox signaling or oxidative stress. This redox activation permits the antioxidant synergy with mitochondrial uncoupling proteins (UCPs) or other SLC25 mitochondrial carrier family members by FA-mediated protonophoretic activity, termed mild uncoupling, that leads to diminishing of mitochondrial superoxide formation. This mechanism allows for the maintenance of the steady-state redox status of the cell. Besides the antioxidant role, we review the relations of iPLA2γ to lipid peroxidation since iPLA2γ is alternatively activated by cardiolipin hydroperoxides and hypothetically by structural alterations of lipid bilayer due to lipid peroxidation. Other iPLA2γ roles include the remodeling of mitochondrial (or peroxisomal) membranes and the generation of specific lipid second messengers. Thus, for example, during FA β-oxidation in pancreatic β-cells, H2O2-activated iPLA2γ supplies the GPR40 metabotropic FA receptor to amplify FA-stimulated insulin secretion. Cytoprotective roles of iPLA2γ in the heart and brain are also discussed.
Tissue Antioxidant Status and Lipid Peroxidation Are Related to Dietary Intake of n-3 Polyunsaturated Acids: A Rabbit Model
Authors: Mattioli Simona , Collodel Giulia , Signorini Cinzia , Cotozzolo Elisa , Noto Daria , Cerretani Daniela , Micheli Lucia , Fiaschi Anna Ida , Brecchia Gabriele , Menchetti Laura , Moretti Elena , Oger Camille , De Felice Claudio , Castellini Cesare
Published: April 2021

Polyunsaturated fatty acid (PUFA) metabolism and tissue distribution is modulated by the oxidation of these molecules. This research aimed to investigate the implication of dietary n-3 PUFA supplementation (precursor and long-chain PUFA) on the PUFA profile and oxidative status of the liver, testis, and brain of adult rabbit bucks. Twenty New Zealand White rabbit bucks were divided into four experimental groups (n = 5 per group) and were fed different diets for 110 days: control (CNT), standard diet containing 50 mg/kg alpha-tocopheryl acetate (vitamin E); CNT+, standard diet + 200 mg/kg vitamin E; FLAX, standard diet + 10% flaxseed + 200 mg/kg vitamin E; or FISH, standard diet + 3.5% fish oil + 200 mg/kg vitamin E. Antioxidants (enzymatic and non-enzymatic), oxidative status (malondialdehyde and isoprostanoids), and n-3 and n-6 PUFAs of tissues were analysed. A chain mechanism of oxidant/antioxidant molecules, which largely depended on the particular PUFA composition, was delineated in the different organs. The liver showed an oxidant/antioxidant profile and lipid pathways widely modulated by PUFA and vitamin E administration; on the other hand, the testis’ oxidative profile rather than its lipid profile seemed to be particularly affected, an outcome opposite to that of the brain (modulation operated by dietary PUFA).
Exoscarne: Assistive Strategies for an Industrial Meat Cutting System Based on Physical Human-Robot Interaction
Authors: Maithani Harsh , Corrales Ramon Juan Antonio , Lequievre Laurent , Mezouar Youcef , Alric Matthieu
Published: April 2021

Musculoskeletal disorders of the wrist are common in the meat industry. A proof of concept of a physical human-robot interaction (pHRI)-based assistive strategy for an industrial meat cutting system is demonstrated which can be transferred to an exoskeleton later. We discuss how a robot can assist a human in pHRI, specifically in the context of an industrial project i.e for the meat cutting industry. We developed an impedance control-based system that enables a KUKA LWR robot to provide assistive forces to a professional butcher while simultaneously allowing motion of the knife (tool) in all degrees of freedom. We developed two assistive strategies—a force amplification strategy and an intent prediction strategy—and integrated them into an impedance controller.
Application of the SWAT-EFDC Linkage Model for Assessing Water Quality Management in an Estuarine Reservoir Separated by Levees
Authors: Hwang Soonho , Jun Sang-Min , Song Jung-Hun , Kim Kyeung , Kim Hakkwan , Kang Moon-Seong
Published: April 2021

Estuarine reservoirs are available for use in various water resource systems. In agriculture, supplying irrigation water that meets water quality standards is essential for food safety. This study focused on the Ganwol estuarine reservoir in the midwestern region of South Korea, which suffers from water quality deterioration problems. To explore the water quality improvement in an estuarine reservoir, it is essential to understand the characteristics of water quality changes in the reservoir following water pollution control management. Therefore, the purpose of this study is to evaluate the effects of water quality management on the estuarine reservoir, which is separated by levees, using the soil and water assessment tool (SWAT)-environmental fluid dynamics code (EFDC) linkage model. In this study, soil remediation by dredging the reservoir’s bottom soil and effluent control from public sewage treatment works were considered as the water management plans. The results of this study indicate that reducing the internal load of the reservoir increases internal resilience and reducing the external inflow load decreases the impact on the system. Hence, comprehensive measures are effective in improving water quality.
Turbine Blade Three-Wavelength Radiation Temperature Measurement Method Based on Reflection Error Correction
Authors: Zheng Kaifeng , Lü Jinguang , Zhao Yingze , Tao Jin , Qin Yuxin , Chen Yupeng , Wang Weibiao , Sun Qiang , Wang Chao , Liang Jingqiu
Published: April 2021

The turbine blade is a key component in an aeroengine. Currently, measuring the turbine blade radiation temperature always requires obtaining the emissivity of the target surface in advance. However, changes in the emissivity and the reflected ambient radiation cause large errors in measurement results. In this paper, a three-wavelength radiation temperature measurement method was developed, without known emissivity, for reflection correction. Firstly, a three-dimensional dynamic reflection model of the turbine blade was established to describe the ambient radiation of the target blade based on the real surface of the engine turbine blade. Secondly, based on the reflection correction model, a three-wavelength radiation temperature measurement algorithm, independent of surface emissivity, was proposed to improve the measurement accuracy of the turbine blade radiation temperature in the engine. Finally, an experimental platform was built to verify the temperature measurement method. Compared with three conventional colorimetric methods, this method achieved an improved performance on blade temperature measurement, demonstrating a decline in the maximum error from 6.09% to 2.13% and in the average error from 2.82% to 1.20%. The proposed method would benefit the accuracy in the high-temperature measurement of turbine blades.
Future Trend in Wearable Electronics in the Textile Industry
Authors: Kan Chi-Wai , Lam Yin-Ling
Published: April 2021

Smart wearable textiles can sense, react, and adapt themselves to external conditions or stimuli, and they can be divided into active and passive smart wearable textiles, which can work with the human brain for cognition, reasoning, and activating capacity. Wearable technology is among the fastest growing parts of health, entertainment, and education. In the future, the development of wearable electronics will be focused on multifunctional, user-friendly, and user acceptance and comfort features and shall be based on advanced electronic textile systems.
Control of Linear Astigmatism Aberration in a Perturbed Axially Symmetric Optical System and Tolerancing
Authors: Sasián José
Published: April 2021

Linear astigmatism aberration is undesirable because it rapidly degrades image quality. We discuss some techniques to control and mitigate this aberration, and provide a comparison of lens systems that have been desensitized for linear astigmatism aberration.
Removal of Organic UV Filters Using Enzymes in Spent Mushroom Composts from Fungicultures
Authors: Yang Chu-Wen , Tu Ping-Hsun , Tso Wen-Yi , Chang Bea-Ven
Published: April 2021

Organic UV filters in sunscreen products are released to aquatic ecosystems through human recreational activities and urban wastewater treatment plant effluents. The biodegradation of three organic UV filters, 2-ethylhexyl salicylate (EHS), homosalate (HMS) and ethylhexyl methoxycinnamate (EHMC), which cannot be effectively removed by conventional wastewater treatment plants, was investigated in this study. Spent mushroom compost (SMC), a waste product of the mushroom industry, which contains white-rot fungus extracellular enzymes, was tested for its ability to remove the three organic UV filters. The results of batch experiments revealed that the SMC enzyme extract of Pleurotus djamor exhibited the highest ability for EHS and HMS removal. The results of bioreactor experiments indicated that direct application of SMCs may be a feasible solution to remove EHS and HMS from urban wastewater. The application of SMCs for the removal of organic UV filters can be developed into a green and sustainable technology.
Boron Neutron Capture Therapy: From Nuclear Physics to Biomedicine
Authors: Bortolussi Silva , Liu Yuan-Hao , Porras Ignacio
Published: April 2021

Boron Neutron Capture Therapy (BNCT) is a binary radiation treatment exploiting a nuclear reaction occurring in tumor cells [...]
Death Anxiety in Social Workers as a Consequence of the COVID-19 Pandemic
Authors: Martínez-López José Ángel , Lázaro-Pérez Cristina , Gómez-Galán José
Published: April 2021

The COVID-19 pandemic has affected all social spaces, conditioning our daily routines, including those at work. All professions have been affected by stressful situations and anxiety in the proximity’s face of death generated by the pandemic. In this context, some professionals have emerged as essential, as social workers, acting in extreme situations in the face of increased demands and social uncertainty arising from the health crisis. The present study aimed to determine the levels of anxiety about death among social workers in Spain. For this purpose, an ad hoc questionnaire was designed, taking the Collett and Lester Fear of Death Scale as a reference (n = 304). The exploitation of the data was carried out from a quantitative perspective. First, a descriptive analysis was performed. Then, binary logistic regressions were carried out on the general scale. The dependent variable in all of them was the risk of suffering death anxiety to the set of its subscales. The main research results show high values of this anxiety in social workers concerning the general value of the scale—and the subscales—and the point of view of state and process. The highest values were Fear of Death of Others (81.6%) and Fear of the Process of Dying of Others (78.3%). Regarding the binary logistic regressions applied, predictor variables were identified in all of them, but the following stand out: Lack of personal protection equipment and Need psychological or psychiatric support. In addition, being a woman increases the risk of suffering Fear of the Dying Process of others.
Antihypertensive Drug Use and the Risk of Ovarian Cancer Death among Finnish Ovarian Cancer Patients—A Nationwide Cohort Study
Authors: Santala Eerik E. E. , Artama Miia , Pukkala Eero , Visvanathan Kala , Staff Synnöve , Murtola Teemu J.
Published: April 2021

Ovarian cancer (OC) has a poor prognosis. Hypertension may be a prognostic factor for OC, but it is unclear whether antihypertensive (anti-HT) drug use of modifies OC prognosis. We performed a population-based analysis assessing the effect of anti-HT drug use on OC mortality. A cohort of 12,122 women identified from the Finnish Cancer Registry with OC in 1995–2013 was combined with information on their anti-HT drug use during the same time period. Use of each anti-HT drug was analysed as a time-dependent variable. Analyses were run for five, ten and full follow-up (19-year) mortality with cardiovascular morbidity risk evaluated in competing risk analysis. No anti-HT drug group was associated with OC survival within five years after OC diagnosis. At ten years, a dose-dependent association was observed between pre-diagnostic ACE-inhibitor use and improved OC survival. With full follow-up, post-diagnostic high-intensity use associated with reduced OC death risk for multiple anti-HT drug groups. In competing risk analysis, only the post-diagnostic use of ACE-inhibitors associated with increased OC survival. Anti-HT drugs were not associated with survival benefits within five years after OC diagnosis. ACE-inhibitors may confer survival benefits in women with OC, but further confirmatory studies are needed.
Traceless Directing Groups in Sustainable Metal-Catalyzed C–H Activation
Authors: Zarkadoulas Athanasios , Zgouleta Ioanna , Tzouras Nikolaos V. , Vougioukalakis Georgios C.
Published: April 2021

Sustainable transformations towards the production of valuable chemicals constantly attract interest, both in terms of academic and applied research. C–H activation has long been scrutinized in this regard, given that it offers a straightforward pathway to prepare compounds of great significance. In this context, directing groups (DG) have paved the way for chemical transformations that had not been achievable using traditional reactions. Few steps, high yields, selectivity and activation of inert substrates are some of the invaluable assets of directed catalysis. Additionally, the employment of traceless directing groups (TDG) greatly improves and simplifies this strategy, enabling the realization of multi-step reactions in one-pot, cascade procedures. Cheap, abundant, readily available transition metal salts and complexes can catalyze a plethora of reactions employing TDGs, usually under low catalyst loadings—rarely under stoichiometric amounts, leading in greater atom economy and milder conditions with increased yields and step-economy. This review article summarizes all the work done on TDG-assisted catalysis with manganese, iron, cobalt, nickel, or copper catalysts, and discusses the structure-activity relationships observed, by presenting the catalytic pathways and range of transformations reported thus far.
Development of a Tri-Functional Nanoprobe for Background-Free SERS Detection of Sialic Acid on the Cell Surface
Authors: Renata Septila , Verma Nitish , Tu Zhijay , Pan Rong-Long , Hofmann Mario , Lin Chun-Hung
Published: April 2021

Sialic acid (SA) on the surface of cells is indispensable in numerous physiological and pathological processes, and sensitive and reproducible detection of SA is crucial for diagnosis and therapy in many diseases. Here, we developed a tri-functional nanoprobe as a sensitive and straightforward surface-enhanced Raman spectroscopy (SERS) nanoprobe for sialoglycan detection on cell surfaces. The reporter was designed to provide three key functionalities that make it ideal for SA detection. First, we employed two recognition groups, phenylboronic acid and an ammonium group, that enhance SA recognition and capture efficiency. Second, we used cyano as the Raman reporter because it emits in the cellular Raman silent region. Finally, thiol acted as an anchoring agent to conjugate the reporter to silver nanocubes to provide SERS enhancement. Our molecular nanoprobe design demonstrated the ability to detect SA on the cell surface with high sensitivity and spatial resolution, opening up new routes to cellular diagnostics.
Helix-Like Receptors for Perrhenate Recognition Forming Hydrogen Bonds with All Four Oxygen Atoms
Authors: Morozov Boris , Ravi Anil , Oshchepkov Aleksandr , Rüffer Tobias , Lang Heinrich , Kataev Evgeny
Published: April 2021

Supramolecular recognition of perrhenate is a challenging task due to therelatively large size and low charge density of this anion. In this work, we design and synthesize a family of helix-like synthetic receptors that can bind perrhenate by forming hydrogen bonds with all four oxygen atoms of the anion. Among the investigated rigid helix-forming subunit derived from 1,1′-ferrocenedicarboxylic acid, 1,3-phenylenediacetic acid and 2,2′-(ethyne-1,2-diyl)dibenzoic acid, the latter one shows the best selectivity for perrhenate recognition. However, the receptor based on 1,1′-ferrocenedicarboxylic acid demonstrates selectivity to bind chloride in a 1:2 fashion. The properties of the receptors are investigated in the acetonitrile solution by using NMR, UV–Vis, and in the solid state by single crystal X-ray analysis.
The Assisted Breathing before Cord Clamping (ABC) Study Protocol
Authors: Meyer Michael P. , Nevill Elizabeth
Published: April 2021

Major physiologic changes occur during the transition after birth. For preterm infants, current understanding favours allowing the initial changes to occur prior to cord clamping. Amongst other improved outcomes, systematic reviews have indicated a significant reduction in neonatal blood transfusions following delayed cord clamping. This may be due to a placental transfusion, facilitated by the onset of respiration. If breathing is compromised, placental transfusion may be reduced, resulting in a greater red cell transfusion rate. We designed a randomised trial to investigate whether assisting respiration in this high-risk group of babies would decrease blood transfusion and improve outcomes. The Assisted Breathing before Cord Clamping (ABC) study is a single-centre randomised controlled trial. Preterm infants < 31 weeks that have not established regular breathing before 15 s are randomised to a standard or intervention group. The intervention is intermittent positive pressure ventilation via T piece for 30 s, whilst standard management consists of 30 s of positioning and gentle stimulation. The cord is clamped at 50 s in both groups. The primary outcome is the proportion of infants in each group receiving blood transfusion during the neonatal admission. Secondary outcomes include requirement for resuscitation, the assessment of circulatory status and neonatal outcomes.
Changes in Umbilico–Placental Circulation during Prolonged Intact Cord Resuscitation in a Lamb Model
Authors: Le Duc Kévin , Aubry Estelle , Mur Sébastien , Besengez Capucine , Garabedian Charles , De Jonckheere Julien , Storme Laurent , Sharma Dyuti
Published: April 2021

Some previous studies reported a benefit to cardiopulmonary transition at birth when starting resuscitation maneuvers while the cord was still intact for a short period of time. However, the best timing for umbilical cord clamping in this condition is unknown. The aim of this study was to explore the duration of effective umbilico–placental circulation able to promote cardiorespiratory adaptation at birth during intact cord resuscitation. Umbilico–placental blood flow and vascular resistances were measured in an experimental neonatal lamb model. After a C-section delivery, the lambs were resuscitated ventilated for 1 h while the cord was intact. The maximum and mean umbilico–placental blood flow were respectively 230 ± 75 and 160 ± 12 mL·min−1 during the 1 h course of the experiment. However, umbilico–placental blood flow decreased and vascular resistance increased significantly 40 min after birth (p < 0.05). These results suggest that significant cardiorespiratory support can be provided by sustained placental circulation for at least 1 h during intact cord resuscitation.
Study of Motor Competence in 4–5-Year-Old Preschool Children: Are There Differences among Public and Private Schools?
Authors: Mecías-Calvo Marcos , Lago-Fuentes Carlos , Arufe-Giráldez Víctor , Navarro-Patón Rubén
Published: April 2021

The objectives of this study were (1) to investigate the presence of preschool children with severe motor difficulties (SMDs) and (2) to evaluate the existence of differences in the motor competence (MC) of preschool children from public and private schools based on gender. A total of 581 preschool children (4.66 ± 0.52 years) from Galicia (Spain) were assessed. The Movement Assessment Battery for Children-2 (MABC-2) was used to collect the data. Preschool children from public schools presented a greater number of SMDs (OR = 20.65; CI = 9.99–85.53; p < 0.001). Preschool children from private schools have higher scores on the variables studied (for example, manual dexterity (p < 0.001), aiming and catching (p < 0.001), balance (p < 0.001), total test score (p < 0.001), and total percentage score (p < 0.001)). Regarding the gender factor, differences were found in manual dexterity (p < 0.001), aiming and catching (p = 0.014), balance (p < 0.001), total test score (p < 0.001), total percentage score (p < 0.001), and in the interaction of both factors in balance (p < 0.001), total global score (p = 0.004), and total percentage score (p < 0.001). Preschool children from private schools are less likely to have severe movement problems and score higher on all dimensions of the MABC-2 than preschool children from public schools analyzed in this study. Likewise, girls score higher than boys in all dimensions, except in aiming and catching.
Moderate-to-Vigorous Physical Activity and Body Composition in Children from the Spanish Region of Aragon
Authors: Ferrer-Santos Pilar , Iglesia Iris , Muñiz-Pardos Borja , Miguel-Berges María Luisa , Flores-Barrantes Paloma , Moreno Luis A. , Rodríguez-Martínez Gerardo
Published: April 2021

Most of the studies analyzing the effect of moderate to vigorous physical activity (MVPA) on children’s health do not contain information on early stages or do not use accurate methods. We investigated the association between PA and body composition using objective methods, perinatal data, lifestyle behaviors, and World Health Organization (WHO) physical activity (PA) recommendations. The CALINA study is a longitudinal observational cohort study of children born in Aragon (Spain) in 2009. A total of 308 7-year-old children (52.3% boys) were assessed. We used dual-energy X-ray absorptiometry (DXA) and accelerometry. Rapid weight gain until 12 months and lifestyle behaviors were considered as covariates both in the ANCOVA and linear regression models. A higher percentage of boys met the WHO PA recommendations compared to girls (69.6% vs. 40.9%, respectively; p < 0.001). There was a negative association between MVPA and subtotal fat and abdominal fat in both girls and boys. After adjusting for perinatal and lifestyle variables, we found that subtotal body fat, abdominal fat, and fat mass index (FMI) were significantly lower in those classified as active. MVPA was associated with body fat both in boys and girls. More research is needed to identify the cutoffs points of MVPA that generate benefit to boys and girls in all body composition components.
Learning Basketball Using Direct Instruction and Tactical Game Approach Methodologies
Authors: González-Espinosa Sergio , García-Rubio Javier , Feu Sebastián , Ibáñez Sergio J.
Published: April 2021

This study was to analyze and compare the learning acquired by the students in the sport of basketball in two different methodologies. The sample was composed of 40 students divided into two groups. The intervention programs had previously been validated. A descriptive analysis of the learning indicators, a t-test for independent samples to identify the differences between the methods, and a t-test for related samples to analyze the differences in each group were performed. There are differences between the performance profiles of students in the Direct Instruction in Basketball program and those in the Tactical Game in Basketball program in nine variables. Significant differences are found in the situations of dribbling, shooting, passing and movement, spacing, off-ball defense, and help and in the performance indicator for decision making, execution, and total, which are favorable to the Tactical Game in Basketball program. The students of the Direct Instruction in Basketball program only improved in three variables after the program, while the Tactical Game in Basketball students improved in thirteen variables. It is recommended that the teachers at the schools use the Tactical Game in Basketball methodology for their basketball teaching lessons, because student learning is better than in the Direct Instruction in Basketball program.
An Assessment of the Validity and Reliability of the Pediatric Child Health Utility 9D in Children with Inflammatory Bowel Disease
Authors: Bashir Naazish S. , Walters Thomas D. , Griffiths Anne M. , Ungar Wendy J.
Published: April 2021

Health utilities relevant to children are lacking, compromising health funding and policy decisions for children. The Child Health Utility 9D (CHU9D) is a recently developed preference-based health utility instrument designed for use in children. The objective was to examine the validity of the CHU9D in a cohort of 285 Canadian children aged 6.5 to 18 years of age with Crohn’s disease (CD) and ulcerative colitis (UC), (collectively inflammatory bowel disease (IBD)). The correlation and agreement between paired CHU9D and Health Utility Index (HUI) assessments were determined with Spearman coefficients and Bland–Altman levels of agreement. Total and domain utilities were calculated for the CHU9D using Australian adult and youth tariffs. Algorithms for HUI2 and HUI3 were used. Domain correlations were determined between domains with expected overlap between instruments. In CD and in UC, correlations between CHU9D, HUI2, and HUI3 utilities ranged between 0.62 to 0.67 and 0.67 to 0.69, respectively (p < 0.05). CHU9D utilities were lower using youth tariffs compared to adult tariffs. A large range in health utilities suggested a heterogeneous quality of life. The CHU9D is a good option for preference-based utility measurement in pediatric IBD. Additional research is required to derive pediatric tariffs to conduct economic evaluation in children.
Lightening Effect of Skin Lightening Cream Containing Piper betle L. Extract in Human Volunteers
Authors: Omar Sharifah Shakirah Syed , Hadi Hazrina , Mohd Hanif Nadzira , Ahmad Hawa Mas Azmar , Ng Shiow-Fern
Published: April 2021

Hyperpigmentation affects people globally with negative psychological impacts. Piper betle L. leaf (PBL) extract has many benefits including skin lightening which may reduce hyperpigmentation. The objective of this study was to develop an effective skin-lightening cream containing PBL with ideal characteristics. A formulation of base cream and PBL cream was prepared and characterized by centrifugation, particle size and zeta potential analysis, rheological profile studies and physical properties’ observation. In vivo studies on 30 human subjects tested the effects of base and PBL cream on skin-lightening, hydration, trans-epidermal water loss (TEWL) and elasticity through weekly tests 4 weeks in duration. Base and PBL creams had a non-Newtonian property with acceptable color, odor, texture, zeta potential, particle size and showed no phase separation. The in vivo study indicated a significant reduction in melanin content and an improvement in skin tone for PBL cream but not in base cream. TEWL and elasticity also showed significant reduction for both formulations, indicating a healthier skin barrier and supple skin with consistent use, although hydration fluctuated with no significant changes. The developed PBL cream showed significant results in the reduction in melanin content and improving skin tone, which shows the formulation can confer skin-lightening effect.
Collection of a Bacterial Community Reconstructed from Marine Metagenomes Derived from Jinhae Bay, South Korea
Authors: Lim Jae-Hyun , Kim Il-Nam
Published: April 2021

Marine bacteria are known to play significant roles in marine biogeochemical cycles regarding the decomposition of organic matter. Despite the increasing attention paid to the study of marine bacteria, research has been too limited to fully elucidate the complex interaction between marine bacterial communities and environmental variables. Jinhae Bay, the study area in this work, is the most anthropogenically eutrophied coastal bay in South Korea, and while its physical and biogeochemical characteristics are well described, less is known about the associated changes in microbial communities. In the present study, we reconstructed a metagenomics data based on the 16S rRNA gene to investigate temporal and vertical changes in microbial communities at three depths (surface, middle, and bottom) during a seven-month period from June to December 2016 at one sampling site (J1) in Jinhae Bay. Of all the bacterial data, Proteobacteria, Bacteroidetes, and Cyanobacteria were predominant from June to November, whereas Firmicutes were predominant in December, especially at the middle and bottom depths. These results show that the composition of the microbial community is strongly associated with temporal changes. Furthermore, the community compositions were markedly different between the surface, middle, and bottom depths in summer, when water column stratification and bottom water hypoxia (low dissolved oxygen level) were strongly developed. Metagenomics data contribute to improving our understanding of important relationships between environmental characteristics and microbial community change in eutrophication-induced and deoxygenated coastal areas.
Percutaneous CT Fluoroscopy-Guided Core Needle Biopsy of Mediastinal Masses: Technical Outcome and Complications of 155 Procedures during a 10-Year Period
Authors: Burgard Caroline , Stahl Robert , de Figueiredo Giovanna Negrao , Dinkel Julien , Liebig Thomas , Cioni Dania , Neri Emanuele , Trumm Christoph G.
Published: April 2021

Purpose: To evaluate technical outcome, diagnostic yield and safety of computed tomographic fluoroscopy-guided percutaneous core needle biopsies in patients with mediastinal masses. Methods: Overall, 155 CT fluoroscopy-guided mediastinal core needle biopsies, performed from March 2010 to June 2020 were included. Size of lesion, size of needle, access path, number of success, number of biopsies per session, diagnostic yield, patient’s position, effective dose, rate of complications, tumor localization, size of tumor and histopathological diagnosis were considered. Post-interventional CT was performed, and patients observed for any complications. Complications were classified per the Society of Interventional Radiology (SIR). Results: 148 patients (age, 54.7 ± 18.2) underwent 155 CT-fluoroscopy-guided percutaneous biopsies with tumors in the anterior (114; 73.5%), middle (17; 11%) and posterior (24; 15.5%) mediastinum, of which 152 (98%) were technically successful. For placement of the biopsy needle, in 82 (52.9%) procedures a parasternal trajectory was chosen, in 36 (23.3%) a paravertebral access, in 20 (12.9%) through the lateral intercostal space and in 17 (11%) the thoracic anterior midline, respectively. A total of 136 (89.5%) of the biopsies were considered adequate for a specific histopathologic analysis. Total DLP (dose-length product) was 575.7 ± 488.8 mGy*cm. Mean lesion size was 6.0 ± 3.3 cm. Neoplastic pathology was diagnosed in 115 (75.7%) biopsies and 35 (23%) biopsy samples showed no evidence of malignancy. Minor complications were observed in 18 (11.6%) procedures and major pneumothorax requiring drainage insertion in 3 interventions (1.9%). Conclusion: CT fluoroscopy-guided percutaneous core needle biopsy of mediastinal masses is an effective and safe procedure for the initial assessment of patients with mediastinal tumors.
AC2: An Efficient Protein Sequence Compression Tool Using Artificial Neural Networks and Cache-Hash Models
Authors: Silva Milton , Pratas Diogo , Pinho Armando J.
Published: April 2021

Recently, the scientific community has witnessed a substantial increase in the generation of protein sequence data, triggering emergent challenges of increasing importance, namely efficient storage and improved data analysis. For both applications, data compression is a straightforward solution. However, in the literature, the number of specific protein sequence compressors is relatively low. Moreover, these specialized compressors marginally improve the compression ratio over the best general-purpose compressors. In this paper, we present AC2, a new lossless data compressor for protein (or amino acid) sequences. AC2 uses a neural network to mix experts with a stacked generalization approach and individual cache-hash memory models to the highest-context orders. Compared to the previous compressor (AC), we show gains of 2–9% and 6–7% in reference-free and reference-based modes, respectively. These gains come at the cost of three times slower computations. AC2 also improves memory usage against AC, with requirements about seven times lower, without being affected by the sequences’ input size. As an analysis application, we use AC2 to measure the similarity between each SARS-CoV-2 protein sequence with each viral protein sequence from the whole UniProt database. The results consistently show higher similarity to the pangolin coronavirus, followed by the bat and human coronaviruses, contributing with critical results to a current controversial subject. AC2 is available for free download under GPLv3 license.
Safe Space, Dangerous Territory: Young People’s Views on Preventing Radicalization through Education—Perspectives for Pre-Service Teacher Education
Authors: Benjamin Saija , Salonen Visajaani , Gearon Liam , Koirikivi Pia , Kuusisto Arniika
Published: April 2021

Initiatives for preventing radicalization and violent extremism through education (PVE-E) have become a feature of global educational policy and educational institutions across all phases, from early childhood to universities, also in Finland. If schools may be regarded as safe spaces here for identity and worldview construction and experiences of belonging, the specific subject matter of PVE-E is also dangerous territory. Not least because of PVE-E’s focus on radicalization, but above all because of perceptions of schools being used as an adjunct of governmental counter-terrorism policy. We argue that understanding young people’s views on issues related to radicalization and violent extremism is critical in order to develop ethical, sustainable, contextualized, and pedagogical approaches to prevent hostilities and foster peaceful co-existence. After providing some critical framing of the Finnish educational context in a broader international setting, we thus examine young people’s views (n = 3617) in relation to the safe spaces through online survey data gathered as a part of our larger 4-year research project Growing up radical? The role of educational institutions in guiding young people’s worldview construction. Specifically focused on Finland but with potentially wider international implications, more understanding about the topic of PVE-E is needed to inform teacher education and training, to which our empirical data makes some innovative contribution.
Analysis and Design of a Fully-Integrated High-Power Differential CMOS T/R Switch and Power Amplifier Using Multi-Section Impedance Transformation Technique
Authors: Kim Hyun-Woong , Ahn Minsik , Lee Ockgoo , Kim Hyoungsoo , Kim Hyungwook , Lee Chang-Ho
Published: April 2021

In this paper, a new topology for a high-power single-pole-double-throw (SPDT) antenna switch is presented, and its loss mechanisms are fully analyzed. The differential architecture is employed in the proposed switch implementation to prevent unwanted channel formations of OFF-state Rx switch transistors by relieving the voltage swing over the Rx switch devices. In addition to that, the load impedance seen by the Tx switch is stepped down to reduce the voltage swing even more, allowing the antenna switch to handle a high-power signal without distortions. To drop the switch operating impedance, two matching networks are required at the input and the output of the Tx switch, respectively, and they are carefully implemented considering the integration issue of the front-end circuitries. From the loss analysis of the whole signal path, an optimum switch operating impedance is decided in view of a trade-off between power handling capability and insertion loss of the antenna switch. The insertion loss of the proposed design is compared to the conventional design with electromagnetic (EM) simulated transformer and inductors. The proposed antenna switch is implemented in a standard 0.18 µm CMOS process, and all switch devices adopt the deep n-well structure. The measured performance of the proposed transmitter front-end chain shows a 1 dB compression point (P1dB) of 32.1 dBm with 38.3% power-added efficiency (PAE) at 1.9 GHz.
Settling of Spherical Particles in High Viscosity Friction Reducer Fracture Fluids
Authors: Biheri Ghith , Imqam Abdulmohsin
Published: April 2021

Investigating the key factors that impact fluid rheology and proppant static settling velocity in high viscosity friction reducers (HVFRs) is a critical aspect for successful proppant transport in hydraulic fracture treatment. In this study, the rheological properties of HVFRs were tested at various temperature ranges (i.e., 25, 50, 75, and 100 °C) and different HVFR concentrations (i.e., 1, 2, 4, and 8 gpt). Three sizes of spherical particle diameters (i.e., 2, 4, and 6 mm) were selected to measure the static settling velocity. The fracture fluid was tested in two fracture models: an unconfined glass model and a confined rectangular model with two fracture widths (7 and 10 mm). The settling velocity in the confined and unconfined models was measured using an advanced video camera. HVFR results exhibited acceptable thermal stability even at higher temperatures, also the viscosity and elasticity increased considerably with increasing concentration. Increasing the temperature cut the friction reducer efficiency to suspend the spherical particles for a significant time, and that was observed clearly at temperatures that reached 75 °C. Spherical particles freely settled in the unconfined model due to the absence of the wall effect, and the settling velocity decreased significantly as the HVFR concentration increased. Additionally, the fracture angularity substantially slowed the proppant settling velocity due to both the wall effect and several types of friction. This research provides insights into the rheological parameters of a high viscosity friction reducer as a fracturing fluid and its efficiency in transporting particles in bounded and unbounded fracture networks.
Current Sharing Control of an Interleaved Three-Phase Series-Resonant Converter with Phase Shift Modulation
Authors: Lin Jing-Yuan , Chen Kuan-Hung , Liu Pin-Hsian , Yueh Hsuan-Yu , Lin Yi-Feng
Published: April 2021

Recently, three-phase series-resonant converters (SRCs) have been proposed for high power applications. Three-phase SRCs can achieve zero-voltage-switching (ZVS) of the primary power switches and regulate the output voltage by pulse-frequency modulation. The interleaving technique is also a conventional method for DC-DC converters to achieve a high power level, reducing the output voltage ripples due to operating out of phase at the same frequency between the two converters. However, an interleaved three-phase SRC cannot easily synchronize switching instants between the two modules due to the component tolerances of circuits. In the proposed control method, phase shift modulation (PSM) is used to solve the output current imbalance caused by component tolerances. The power switches of the converter can also maintain synchronizing switching instants between the two modules. Therefore, the lower output voltage ripple can be achieved. A detailed analysis and design of this new control method for interleaved three-phase SRCs are described. Finally, prototype converters with a 2.4 kW total output were built and successfully tested to verify the feasibility of the current sharing modulation.
Handling Initial Conditions in Vector Fitting for Real Time Modeling of Power System Dynamics
Authors: Bradde Tommaso , Chevalier Samuel , De Stefano Marco , Grivet-Talocia Stefano , Daniel Luca
Published: April 2021

This paper develops a predictive modeling algorithm, denoted as Real-Time Vector Fitting (RTVF), which is capable of approximating the real-time linearized dynamics of multi-input multi-output (MIMO) dynamical systems via rational transfer function matrices. Based on a generalization of the well-known Time-Domain Vector Fitting (TDVF) algorithm, RTVF is suitable for online modeling of dynamical systems which experience both initial-state decay contributions in the measured output signals and concurrently active input signals. These adaptations were specifically contrived to meet the needs currently present in the electrical power systems community, where real-time modeling of low frequency power system dynamics is becoming an increasingly coveted tool by power system operators. After introducing and validating the RTVF scheme on synthetic test cases, this paper presents a series of numerical tests on high-order closed-loop generator systems in the IEEE 39-bus test system.
Adaptive Mho Distance Protection for Interconnected Transmission Lines Compensated with Thyristor Controlled Series Capacitor
Authors: Abo-Hamad Ghada M. , Ibrahim Doaa Khalil , Aboul Zahab Essam , Zobaa Ahmed F.
Published: April 2021

This paper proposes an adaptive dynamic Mho distance relay based on a phase comparator scheme for protecting interconnected transmission networks compensated with a Thyristor Controlled Series Capacitor (TCSC). The proposed relay uses an impedance index factor to initiate the fault detection subroutine. The RMS of the positive sequence current of the faulted loop and the TCSC terminal current are compared for TCSC zone identification. A phase comparator for ground and phase distance elements is proposed, relying on the positive sequence voltage as a polarized memory quantity, while the operating and polarizing quantities are developed using estimated TCSC impedance to mitigate its negative impact. The proposed scheme is easy in implementation and independent on synchronized data transfer, as minimum communication requirements are needed. To evaluate the performance of the proposed scheme, extensive simulation studies were carried out on an IEEE9 bus system compensated with TCSC for different firing angles covering four modes of TCSC operations, different fault types, and fault locations. In addition, an IEEE-39 bus network, as a large interconnected system, is tested for validation purposes. The achieved results designate the precision of the proposed scheme. Moreover, the results indicate its effectiveness for fault resistance tolerance, close-in three phase faults, and stable power swing phenomenon compared with conventional relays.
Identification of TV Channel Watching from Smart Meter Data Using Energy Disaggregation
Authors: Schirmer Pascal A. , Mporas Iosif , Sheikh-Akbari Akbar
Published: April 2021

Smart meters are used to measure the energy consumption of households. Specifically, within the energy consumption task, a smart meter must be used for load forecasting, the reduction in consumer bills as well as the reduction in grid distortions. Smart meters can be used to disaggregate the energy consumption at the device level. In this paper, we investigated the potential of identifying the multimedia content played by a TV or monitor device using the central house’s smart meter measuring the aggregated energy consumption from all working appliances of the household. The proposed architecture was based on the elastic matching of aggregated energy signal frames with 20 reference TV channel signals. Different elastic matching algorithms, which use symmetric distance measures, were used with the best achieved video content identification accuracy of 93.6% using the MVM algorithm.
Public Participation in Biodiversity Impact Assessment in the State of West Bengal, India: Present Status and Finding Ways for Improvement
Authors: Chakraborty Rajarshi , Lindner Andre , Wende Wolfgang
Published: April 2021

The present status of public participation in EIA particularly concerning biodiversity in West Bengal, India was studied. The issues raised in 50 public hearings were analyzed and chapters on biodiversity in 20 EIA reports were studied. Areas needing improvement were identified. Scientific literature was studied to gather best practices/concepts. It was observed that, despite all enabling legal provisions, public participation in EIA has not grown to its full potential. The discussion was mostly on jobs and benefits (and little on biodiversity impact). EIA reports did not provide any spatial information on biodiversity-rich/sensitive areas or impact on bio-resources that are used by people. We identified four pillars of effective public participation in EIA as: (i) institutional opportunity and conducive environment for participation; (ii) interest of local people to participate; (iii) capacity building of local people; and, (iv) support of clearance process. Specific recommendations under each are provided. A simple matrix for Biodiversity Impact Assessment and a list of components for the improvement of biodiversity, for use of local people, have been developed.
Psyllium Improves the Quality and Shelf Life of Gluten-Free Bread
Authors: Fratelli Camilly , Santos Fernanda Garcia , Muniz Denise Garcia , Habu Sascha , Braga Anna Rafaela Cavalcante , Capriles Vanessa Dias
Published: April 2021

Psyllium husk powder was investigated for its ability to improve the quality and shelf life of gluten-free bread. Gluten-free bread formulations containing 2.86%, 7.14%, and 17.14% psyllium by flour weight basis were compared to the control gluten-free bread and wheat bread in terms of performance. The effect of time on crumb moisture and firmness, microbial safety, and sensory acceptability using a 10-cm scale was assessed at 0, 24, 48, and 72 h postproduction. Crumb firming was observed during the storage time, especially for the control gluten-free bread, which had a crumb firmness 8-fold higher than that of the wheat bread. Psyllium addition decreased the crumb firmness values by 65–75% compared to those of the control gluten-free bread during 72 h of storage. The longest delay in bread staling was observed with a 17.14% psyllium addition. The psyllium-enriched gluten-free bread was well accepted during 72 h of storage, and the acceptability scores for aroma, texture, and flavor ranged from 6.8 to 8.3, which resembled those of wheat bread. The results showed that the addition of 17.14% psyllium to the formulation improved the structure, appearance, texture, and acceptability of gluten-free bread and delayed bread staling, resembling physical and sensory properties of wheat bread samples during 72 h of storage. Therefore, according to the obtained results, this approach seems to be promising to overcome some of the limitations of gluten-free breadmaking.
Constraints on Space-Time-Matter Theory in the Framework of the Standard-Model Extension
Authors: Overduin James , Ali Hamna , Walz Francis
Published: April 2021

We use experimental limits on Lorentz violation within the framework of the Standard-Model Extension to derive quantitative constraints on Space-Time-Matter theory, a version of Kaluza–Klein theory in which the cylinder condition is relaxed so that four-dimensional physics can in principle depend on the extra coordinates. The extra dimensions are not necessarily compact or length-like. We find that the associated variation in fundamental quantities such as rest mass must occur slowly, on cosmological scales.