bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Cultural Distance Across Quantiles of International Joint Venture Longevity
Authors: Tower Annette P. , Hewett Kelly , Fenik Anton P.
Published: September 2019

Rapid global economic development and liberalization have increased the motivation and opportunities for firms to enter into international joint venture (IJV) agreements. Numerous studies in the international marketing literature have examined the impact of international partners’ cultural differences on IJV longevity; however, results are inconclusive, potentially due to limitations in the methods used. While this study examines the varied impact of cultural differences on IJV longevity based on the IJV’s age, it uses quantile regression, enabling the detection of varying effects’ strengths across the dependent variable’s entire distribution. The results demonstrate variations in the role of cultural differences across individual cultural dimensions as well as variations in the patterns of association between cultural differences and IJV longevity dependent on the IJV’s age. Implications for theory and the practice of international marketing are offered as well as potential applications of this study’s methodological approach.
Communicating a Health Risk/Crisis: Exploring the Experiences of Journalists Covering a Proximate Epidemic
Authors: Thompson Esi E.
Published: September 2019

Media are an indispensable partner in health communication, but there is often concern about how the media cover health and science issues. These critiques tend to be based on analyses of news content that don’t consider the production process of the content. Using a media sociology framework, the article examines the news production process of the Ebola outbreak from the perspective of Ghanaian journalists. The study finds that existing and new routines influenced what the media produced. This study reiterates the call for public health to work closely with the media and to provide translated health information in multilingual low-literate societies.
Second Screening and the Engaged Public: The Role of Second Screening for News and Political Expression in an O-S-R-O-R Model
Authors: Chen Hsuan-Ting
Published: September 2019

Second screening has become a prevalent media consumption behavior. Nevertheless, the political implications of second screening are not fully understood. Using data from a two-wave panel survey in Hong Kong, this study examines the role of second screening in contributing to an engaged public based on the Orientation-Stimulus-Reasoning-Orientation-Response (O-S-R-O-R) model. In addition, second screening behaviors are differentiated into second screening for news and for expression. The findings show that these two behaviors play significant but different roles in influencing citizens’ cognitive (i.e., political knowledge) and psychological (i.e., political efficacy) development. This hybrid media practice also affects political participation directly and indirectly through interpersonal discussion, political knowledge, and political efficacy. Implications of the findings for the development of participatory democracy are discussed.
The Association Between Sexually Aggressive Cognitions and Pathological Personality Traits in Men
Authors: Kasowski Amanda E. , Anderson Jaime L.
Published: September 2019

Sexual aggression, harassment, and sexually aggressive cognitions (victim blaming, sexual entitlement) are serious societal problems. Although research has examined attributes of individuals who engage in overt sexual assault, few studies have focused on individual characteristics of those who perpetuate problematic negative beliefs surrounding sexual assault. This study sought to examine the relationship between pathological personality and sexually aggressive cognitions among 242 community men. Results showed that traits including antagonism, disinhibition, and negative affectivity were associated with sexually aggressive cognitions. These results have implications for understanding sexual aggression and the role personality plays in perpetuating sexually aggressive attitudes.
When Voters Matter: The Limits of Local Government Responsiveness
Authors: Sances Michael W.
Published: September 2019

I use over-time variation resulting from geographic sorting to estimate the impact of local preferences on local policy. Building a new panel data set of county-level voting behavior and county-level policy choices, I find a causal impact of changes in preferences on changes in policy. However, this responsiveness is not unlimited. While public safety and infrastructure spending respond, policies more constrained by state laws do not; and while general purpose government spending is responsive, school and special district spending are not. These results corroborate recent evidence of local responsiveness using a more extensive sample, and a research design that rules out many alternative explanations. They also reveal many local policies to be unresponsive due to state-imposed constraints.
4- to 8-year complication analysis of 2 ‘partial collum’ femoral stems in primary THA
Authors: Buttaro Martin A , Slullitel Pablo A , Oñativia José I , Nally Francisco , Andreoli Mauro , Salcedo Ricardo , Comba Fernando M , Piccaluga Francisco
Published: September 2019

Objectives:

Compare the clinical and radiological outcome of CFP stem with the MiniHip design in a prospective series, with special interest in intraoperative periprosthetic fracture (IPPF).

Methods:

We prospectively followed 101 cases treated with the MiniHip stem (Group 1) and 89 with the CFP stem (Group 2) operated between 2010 and 2014. No significant demographic differences were observed between both groups. Median follow-up was 72 months. Average stem length was 41% shorter in the MiniHip group ( p  < 0.001). Radiological parameters were measured and a logistcic regression model was created to evaluate factors associated with IPPF.

Results:

Mean mHHS improved from 54 to 95 in the MiniHip group ( p  < 0.001) and from 64 to 98 in the CFP group ( p  < 0.001). No significant differences were observed in terms of loosening, infection or instability. We observed 7 IPPFs (3.68%), 3 in group 1 and 4 in group 2. After adjusting for confounders, CFP was not associated with a greater risk of IPPF (OR 3.23; 95% CI, 0.250–42.034, p  = 0.368), however, a more complex fracture pattern was observed with this stem design. Prior acetabular fractures were associated with IPPF (OR 66.85; 95% CI, 1.142–3911, p  = 0.043). Compared to Dorr A femurs, type Dorr B appeared protective against IPPF (OR 0.039; 95% CI, 0.001–1.109, p  = 0.058). Valgus alignment tended to increase the risk of IPPF (OR 20.59; 95% CI 0.870–487.221, p  = 0.061).

Conclusions:

MiniHip showed similar radiological outcomes to CFP at short- to mid-term follow-up without increasing IPPFs with a shorter stem length. Given that CFP produced a more complex IPPF pattern, surgeons should be cautious with alignment of this particular design, especially in Dorr A femur.
Gender Differences in Smoking Among an Urban Emergency Department Sample
Authors: Cunradi Carol B , Lee Juliet , Pagano Anna , Caetano Raul , Alter Harrison J
Published: September 2019

Background:

Urban emergency department (ED) patients have elevated smoking and substance use compared with the general population. We analyzed gender differences in smoking among an urban ED sample and assessed the contribution of substance use, demographic, and couple factors.

Methods:

We conducted a secondary analysis of data obtained from a cross-sectional, observational survey (N = 1037 participants) on drinking, drug use, and intimate partner violence (IPV). Gender-specific logistic regression models for current (past 30-day) smoking and multinomial regression models for smoking intensity (light: ⩽5 cigarettes per day [CPD]; moderate: 6 to 10 CPD; heavier: >10 CPD) were estimated.

Results:

Smoking prevalence was higher among men than women (35.5% vs 18.9%; P < .001). Substance use (frequency of intoxication, marijuana, amphetamine, and cocaine use), demographic (food insufficiency, unemployment), and couple-related factors (having a spouse/partner who smoked, IPV involvement, being in a same-gender couple) were differentially associated with current smoking and level of intensity among men and women.

Conclusions:

Emergency department staff should consider the impact of polysubstance use, food insufficiency, unemployment, and whether both partners in the couple smoke when screening patients for smoking and formulating cessation treatment plans. Women in same-gender relationships and those who have experienced IPV involvement may require additional referral.
Theoretical and experimental investigation of non-asbestos friction lining material applied in automotive drum brake
Authors: Shinde Dinesh Subhash , Mistry KN , Bulsara Mukesh
Published: September 2019

Automotive brakes are the important machine element which provides an artificial frictional resistance to control the speed of an automobile. In the present work, theoretical models for the coefficient of friction between brake drum and friction liner are generated and simulated using MATLAB Simulink. A test set up designed and manufactured according to the brake lining quality test procedure (SAE J661) is used to investigate tribological properties of a non-asbestos friction lining material having 11 different constituents, which is manufactured from one of the brake liner manufacturer. An experiment is designed using response surface methodology (RSM) with vehicle speed, braking force, and sliding distance as the input parameters, whereas coefficient of friction and wear as an output. It is found that vehicle speed is the most significant parameter among the three. Fade and recovery behavior of the friction lining material is also studied and it is found that the developed friction lining material satisfies the criteria specified in SAE J661. Scanning electron microscope (SEM) and energy dispersive spectoscopy (EDS) have revealed the significant surface phenomenon.
Two kinds of music therapy: Exploring ‘genre’ in the context of clinical practice
Authors: Annesley Luke
Published: September 2019

This article explores distinctions between different approaches to music therapy and how these distinctions might be relevant to clinical practice. The article adopts an exploratory subjective stance, with the author exploring the relevance of a perceived distinction between ‘music-centred’ and ‘psychodynamic’ music therapy, as described in the literature, to their own clinical practice. A series of clinical vignettes, taken from work with children and young people, are used to illustrate the influence of both psychodynamic and music-centred theories on clinical practice in context. An integrative client-centred approach is proposed, where psychodynamic thinking and music-centred ideas can be incorporated as needed, according to the individual needs of each client.
One at a Time: LGBTQ Polyamory and Relational Citizenship in the 21st Century
Authors: Santos Ana Cristina
Published: September 2019

Drawing on biographic narrative interviews with self-identified lesbian, gay, bisexual, trans, and/or queer polyamorous people in Portugal, this article explores the contradictions and opportunities involved in living as a relationally diverse LGBTQ intimate citizen in Southern Europe. The article starts by unpacking citizenship in relation to dominant sociolegal expectations around monogamy. In this section, it is suggested that the mononormative underpinnings of law and social policy restrain intimate citizenship. The second part of the article explores the legal and cultural meanings attached to coupledom, suggesting the notion of relational performativity as an analytical tool for interpreting cultural norms and expectations around partnering. The last section discusses citizenship and coupledom in light of the biographic narratives produced by LGBTQ polyamorous participants in the INTIMATE study in Portugal. Based on thematic analysis of these narratives, it is argued that the framework of intimate citizenship is not fixed, and the notion of relational citizenship is offered. Arguably, relational citizenship enables a gradual detachment from the strictly monogamous underpinnings of citizenship studies, hence offering an opportunity for further intellectual engagement with intimacy and diversity in the 21st century.
Beliefs about suspect alibis: A survey of lay people in the United Kingdom, Israel, and Sweden
Authors: Portnoy Shiri , Hope Lorraine , Vrij Aldert , Ask Karl , Landström Sara
Published: September 2019

During police interviews, innocent suspects may provide unconvincing alibis due to impaired memory processes or guilt-presumptive behaviour on behalf of the interviewer. Consequently, innocent suspects may be prosecuted and tried in court, where lay people who serve jury duty will assess their alibi’s credibility. To examine lay people’s beliefs and knowledge regarding suspect alibis, and specifically about such factors that may hamper innocent suspects’ ability to provide convincing alibis, we administered an eight-question questionnaire across the United Kingdom ( n = 96), Israel ( n = 124), and Sweden ( n = 123). Participants did not tend to believe that innocent suspects’ alibis might inadvertently include incorrect details, but acknowledged that impaired memory processes may cause this. Additionally, most participants believed that a presumption of guilt can affect how interviewers interview suspects. The findings suggest that lay people who may serve jury duty hold some mistaken beliefs regarding alibi provision by suspects.
An experimental study on the effect of frame-to-wall connection type on the seismic behavior of steel frames infilled with autoclave-cured aerated concrete blocks
Authors: Asadzadeh Saheb Ali , Mohammadi Majid , Attari Nader Khajeh Ahmad , Zareei Seyed Alireza
Published: September 2019

In this article, in order to find some reliable connection types for avoiding the infill failure, an experimental study is conducted on six half-scale single-story single-bay specimens, including one bare frame and five steel frames with autoclave-cured aerated concrete walls, each having different frame-to-wall connection types. Polyurethane adhesive was used in bed joints of the autoclave-cured aerated concrete walls as a mortar. The specimens were tested under displacement-controlled loading to examine their effect on the in-plane behavior of steel frames. The results suggested that V- and T-shaped connectors can be used as prequalified connectors between the wall and the frame. In specimens with these connectors, the interaction between infill and frame was ignorable and the infill remained intact up to life safety performance level (2.5% drift ratio). Furthermore, the application of these connectors resulted in a two-level performance of the infill whereby the frame stiffness degradation and strength deterioration after the drift ratio of 2.5% was compensated.
A Novel Lay Health Worker Training to Help Women Engage in Postabortion Contraception and Well-Woman Care
Authors: Chor Julie , Young Danielle , Quinn Michael T. , Gilliam Melissa
Published: September 2019

Young women, low-income women, and women of color make up a disproportionate share of abortion patients and experience higher rates of unintended pregnancy, maternal morbidity and mortality, and infant mortality. Furthermore, these individuals are also less likely to have access to preventive gynecologic care. Whereas lay health worker interventions have been developed to help link individuals to care in other fields, the use of such interventions to link individuals to preventive care after abortion is novel. This article describes a training protocol and curriculum that provided nonmedically trained individuals with knowledge, skills, and competency to conduct a behavioral theory–based counseling intervention to help individuals achieve self-identified goals regarding obtaining postabortion reproductive health care and contraception. When piloted with 60 patients presenting for abortion who lacked a regular health care provider and desired to delay pregnancy for at least 6 months, participants found the lay health worker skills and the counseling session highly acceptable. Specifically, participants reported feeling comfortable speaking to lay health workers about contraception and reproductive health care. These findings indicate that lay health worker interventions may present an important opportunity to help individuals address their postabortion preventive and contraceptive health care needs.
The “Narco-stories” of Kate del Castillo: Stardom, Gender, and Entrepreneurship in a Transnational Context
Authors: Llamas-Rodriguez Juan
Published: September 2019

This article analyzes the transnational persona of actress Kate del Castillo across her portrayals of female narcotraffickers, her transmedia interactions with audiences, and her pursuit of a film project on the life of Joaquín “El Chapo” Guzmán, former leader of the Sinaloa Cartel. Through discourse and textual analysis of news coverage, popular media, and first-person testimonials, this article argues that del Castillo’s persona of a rogue entrepreneur on-screen and off-screen shaped her success and made her a target for state and media organizations. Del Castillo’s narrative struggles across media and languages countered longstanding conceptions of women’s roles in narcotrafficking and in narco-cultural productions. The article illuminates the continued appeal that the cultural grammar of narcotrafficking holds as a way to articulate power in North America.
Maximally Disfiguring Surgery for Forefoot Osteomyelitis: Time for a Rethink?
Authors: Lee Han Jie , Chin Ken Min , Lee Shaun , Yap Hao Yun , Ch’ng Jack Kian , Chng Siew Ping , Tay Hsien Ts’ung
Published: September 2019

The treatment of choice for diabetic foot osteomyelitis is surgical debridement and targeted antibiotics with or without revascularization, depending on vascular status. In our society, debridement is done by either a vascular or orthopedic surgeon, and the common teaching is that generous amputation of bone with the accompanying soft tissue envelope is essential for adequate source control and to prevent recurrence (which remains as high as 30% even with this approach). Most of our patients undergo formal ray amputation through the metatarsal neck, while a few get digital amputations through the interphalangeal joints. Many of the resultant wounds cannot be closed and are left to heal by secondary intention. These amputations invariably alter the biomechanics of the foot and leave large and slow-healing open wounds, which have associated adverse psychosocial impacts. We describe 2 cases of patients who had osteomyelitis in the region of the forefoot who underwent complete bony resections of the osteomyelitis but with sparing of the soft tissue envelopes with good outcomes, and we challenge the dogma that maximal debridement of soft tissue must accompany debridement of necrotic and infected bone.
Effects of rice husk fibers on the properties of mixed-particle-size fiber-reinforced polyvinyl chloride composites under soil accelerated aging conditions
Authors: Wang Lei , He Chunxia
Published: September 2019

In this article, rice husk fiber/polyvinyl chloride composites were prepared and analyzed. The optimal composition of mixed-particle-size fiber-reinforced composites was determined through orthogonal experimentation. The physical, mechanical, and thermal properties of the mixed-particle-size fiber-reinforced composites were compared to unprocessed (100 mesh) rice husk fiber/polyvinyl chloride composites. The surface microscopic appearances of the unprocessed and final composites were observed via laser microscope. Long-term accelerated soil aging caused micro-cracks to appear on the surfaces of the composites. Interfacial adhesion was observed via scanning electron microscopy. The results indicated that mixed-particle-size fibers can better fill interfacial gaps, leading to strong interfacial adhesion. Furthermore, the addition of mixed-particle-size fibers improves the soil aging resistance of composites. The hardness, flexural strength, impact strength, and first onset pyrolysis temperature (after 0 days) increase from 50 HRR, 35.2 MPa, 3.19 KJ/m2, and 258.5°C to 55 HRR, 39.4 MPa, 3.86 KJ/m2, and 261.2°C, respectively. However, the mass loss rate and thickness expansion rate (after 21 days) decrease from 2.9% and 0.79% to 2.21% and 0.74%, respectively. In general, the addition of mixed-particle-size fibers improves the ultimate properties of composites under soil aging conditions.
TRESK alleviates trigeminal neuralgia induced by infraorbital nerve chronic constriction injury in rats
Authors: Li Yuanyuan , Jiao Hena , Ren Wenan , Ren Fei
Published: September 2019

Trigeminal neuralgia commonly results in pain behaviors and cognitive impairment. Convincing evidence suggests that TWIK-related spinal cord K+ (TRESK) exerts antinociceptive and neuroprotective effects. However, its possible potentials in trigeminal neuralgia remain unclear. Trigeminal neuralgia model was established in rats by generating an infraorbital nerve chronic constriction injury, and rats received intrathecal injections of TRESK-overexpressing lentivirus and siRNA expression vector-targeted against TRESK (si-TRESK) into the trigeminal ganglions. Mechanical allodynia was evaluated by mechanical withdrawal threshold. Cognitive capacity was tested using Morris water maze. The TRESK expression was determined by quantitative real-time polymerase chain reaction and Western blotting. Results showed that the mRNA and protein levels of TRESK were significantly downregulated in trigeminal ganglions in injured rats. Intrathecal treatment with TRESK reduced mechanical allodynia and relieved learning and memory deficits in trigeminal neuralgia rats, while si-TRESK injection caused neuropathic pain and cognitive deficits. In summary, the present study concluded that TRESK ameliorated pain-associated behaviors and cognitive deficits, which was useful as an alternative approach in management of trigeminal neuralgia.
Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation
Authors: Goërtz Yvonne M. J. , Spruit Martijn A. , Van ‘t Hul Alex J. , Peters Jeannette B. , Van Herck Maarten , Nakken Nienke , Djamin Remco S. , Burtin Chris , Thong Melissa S. Y. , Coors Arnold , Meertens-Kerris Yvonne , Wouters Emiel F. M. , Prins Judith B. , Franssen Frits M. E. , Muris Jean W. M. , Vanfleteren Lowie E. G. W. , Sprangers Mirjam A. G. , Janssen Daisy J. A. , Vercoulen Jan H.
Published: September 2019

Background:

The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity.

Methods:

A total of 1290 patients with COPD [age 65 ± 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 ± 19% predicted] and 199 subjects without COPD (age 63 ± 9 years, 51% male, FEV1 112 ± 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity.

Results:

Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 ± 12 versus 21 ± 11 points, p < 0.001; 49 versus 10%, p < 0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient = −0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables.

Conclusions:

Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.
Emotion in Cultural Dynamics
Authors: Kashima Yoshihisa , Coman Alin , Pauketat Janet V. T. , Yzerbyt Vincent
Published: September 2019

Emotion is critical for cultural dynamics, that is, for the formation, maintenance, and transformation of culture over time. We outline the component micro- and macro-level processes of cultural dynamics, and argue that emotion not only facilitates the transmission and retention of cultural information, but also is shaped and crafted by cultural dynamics. Central to this argument is our understanding of emotion as a complete information package that signals the adaptive significance of the information that the agent is processing. It captures an agent’s appraisal about the relationship between themself and the object of emotional focus, as well as action orientation and allostasis in context. We discuss implications of this perspective in the context of the changing natural and geopolitical environment, and future cultural dynamics into the 21st century.
Protective Effect of Coptis chinensis Polysaccharide Against Renal Injury by Suppressing Oxidative Stress and Inflammation in Diabetic Rats
Authors: Jiang Shuang , Tang Yong , Bao Yang , Su Xin , Li Kexin , Guo Yan , Liu Zhi , Song Wu
Published: September 2019

Our previous studies confirmed that Coptis chinensis polysaccharide (CCPW) had a good antidiabetic activity and could improve insulin resistance. However, whether CCPW has a protective effect against the renal injury caused by diabetes has not been reported. In this study, the protective effect of CCPW against the renal injury of diabetic rats and its underlying mechanisms were investigated. The results showed that in CCPW-treated groups, the body mass of rats increased significantly, while the ratio of kidney weight to body weight decreased significantly; the 24-hour urine protein and the serum BUN and serum creatinine (Scr) levels decreased significantly, and pathological changes of the renal tissue were improved; superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities in the renal tissue were significantly higher, and malondialdehyde (MDA) contents in the renal tissue, and tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and hypersensitive c-reactive protein (hs-CRP) levels in the serum were significantly lower; the expressions of phosphorylated tyrosine kinase 2 (p-JAK2) and activators of transcription 3 (p-STAT3) decreased significantly. The results indicate that CCPW should have a protective effect against the renal injury in diabetic rats, which may be associated with its inhibition on oxidative stress and inflammation.
Toward Integration of the Niche Diversity Hypothesis With Other Explanations for Personality Covariation: Reply to Međedović's (2019) Commentary on Lukaszewski et al. (2017)
Authors: Lukaszewski Aaron , Gurven Michael , von Rueden Christopher R. , Smaldino Paul
Published: September 2019

The hypothesis of a human-universal personality structure is undermined by cross-cultural studies in small-scale societies. To explain cross-population differences in patterns of behavioral covariance, we proposed the niche diversity hypothesis, which holds that the degree of behavioral covariation within a population is inversely related to the number and diversity of niches within its socioecology. This hypothesis is formalized as a computational model, and its predictions have been supported empirically. Herein, we respond to several important issues regarding this line of research that were raised in a recent commentary: (1) the study of specific behavioral syndromes should be integrated into the niche diversity model; (2) environmental harshness might alternatively explain our cross-cultural findings regarding effects of niche diversity; and (3) better definitions of behavioral traits are needed for future research. We conclude that the niche diversity hypothesis can be integrated with other explanations for cross-cultural differences in personality covariation.
Seeing Gender: Perceptual Representations of Transgender Individuals
Authors: Howansky Kristina , Albuja Analia , Cole Shana
Published: September 2019

In four studies, we explored perceptual representations of the gender-typicality of transgender individuals. In Studies 1a and 1b, participants ( N = 237) created an avatar based on an image of an individual who disclosed being transgender or did not. Avatars generated in the transgender condition were less gender-typical—that is, transmen were less masculine and transwomen were less feminine—than those created in the control condition. In Study 2 ( N = 368), using a unique visual matching task, participants represented a target labeled transgender as less gender-typical than the same target labeled cisgender. In Study 3 ( N = 228), perceptual representations of transwomen as less gender-typical led to lower acceptability of feminine behavior and less endorsement that the target should be categorized as female. We discuss how biased perceptual representations may contribute to the stigmatization and marginalization of transgender individuals.
Using the pharmacy retail model to examine perceptions and biases of a UK population sample towards regulation of specific psychoactive drugs
Authors: James Edward , Robertshaw Thomas L , Pascoe Michael J , Chapman Fiona M , Westwell Andrew D , Smith Andrew P
Published: September 2019

Background:

Contemporary research indicates that the legal classifications of cannabis (Schedule 2, Class B), 3,4-methylenedioxymethamphetamine (MDMA) (Schedule 1, Class A) and psilocybin (Schedule 1, Class A) in the United Kingdom are not entirely based on considerations of harm and therapeutic utility. The legal classifications of the substances discussed are typically determined by legislators such as Parliament and, therefore, may be a reflection of the views or perceived views of the general public.

Objective:

The aim of the study was to provide an indication of the underlying psychology regarding the legislated sale of alcohol, tobacco, cannabis, MDMA and psilocybin in pharmacies according to a UK general population sample.

Methods:

A sample of 105 UK nationals was selected for the survey. Participants were asked questions on perceived relative harm of the five substances. After viewing contemporary information on reported relative harm and therapeutic applications, the participants were asked questions related to using the pharmacy retail model for the sale of the substances discussed. Participants who opposed the substances being sold primarily in pharmacies were asked to explain their rationale according to a predetermined list of options for each of the five drugs. Participants were also asked whether they consider it a human right to be legally permitted to consume the substances.

Results:

The participants' perceptions of relative harm (tobacco > MDMA > psilocybin > alcohol > cannabis) were not in agreement with the relative harm reported in the literature (alcohol > tobacco > cannabis > MDMA > psilocybin). Principal objections to the currently illicit substances being legally available in pharmacies include it sending the wrong message; it feels wrong; it is too dangerous; disliking the smell of cannabis; disapproval of the people; and not liking the idea of people using psychoactive drugs for entertainment or to have mystical/religious experiences. Overall, the participants determined that being legally permitted to consume the substances discussed is an issue of relevance to human rights. A majority of the male participants concluded that being legally permitted to consume alcohol, tobacco, cannabis and Psilocybe mushrooms is a human right in contrast to the majority of female participants who solely considered alcohol consumption to be a human right.

Conclusions:

The data suggest that the legal classifications may not simply be based on considerations of harm. Misperceptions of the dangers, biases and non-health-related aversions likely contribute to the continuation of policies that do not reflect the state of scientific research.
Academia–industry digital health collaborations: A cross-cultural analysis of barriers and facilitators
Authors: Liu Chelsea , Shao Shuai , Liu Chang , Bennett Gary G. , Prvu Bettger Janet , Yan Lijing L
Published: September 2019

Background

Development and uptake of digital health technologies benefit from cross-sectoral efforts from academia and industry. Our study aims to identify the barriers and facilitators associated with academia–industry collaborations in digital health in middle- and high-income countries.

Methods

Trained personnel conducted semi-structured interviews with 23 stakeholders who were active in industry, academia or both. Stakeholders were based in middle-income countries (including China) and high-income countries (including the United States) as defined by the World Bank. Interviews were conducted in the stakeholder’s language of choice (Chinese, n = 12; English, n = 11). Qualitative interview questions elicited perspectives on stakeholders’ experience with academia–industry collaboration, challenges faced, and factors that facilitated the process. Interviews were audiotaped, transcribed verbatim, thematically coded by bilingual coders and analyzed using inductive content analysis.

Results

Stakeholders in both academia and industry identified complementary roles, authentic communication between partners, and clearly outlined goals or expectations prior to the collaboration as primary facilitators for success. Misaligned goals or expectations, differences in timelines for productivity and difficulties balancing expectations for business outcomes versus generation of scientific evidence were identified as primary barriers. Stakeholders in high-income countries reported inauthentic communication as a significant barrier to collaboration, whereas those in middle-income countries did not.

Conclusion

Outlining and communicating openly about goals and expectations for timeline and priorities as well as establishing complementary roles will facilitate fruitful academia–industry collaborations in the future. Best practices for communication styles may be dependent on the cultural setting, and thus should be adopted accordingly.
Postmarketing Safety of Biosimilars: Current Status, Challenges, and Opportunities in the Spontaneous Reporting System
Authors: Singh Abhishek , Kalaivani Muthusamy , Srivastava Sushma , Goyal Ramesh K. , Gupta Suresh K.
Published: September 2019

Recombinant drug products successfully treat many life-threatening and chronic diseases. The high cost of these drugs makes them inaccessible to the patients particularly in developing countries. Patent expiration of innovator recombinant drug products has led to the development of biosimilars or similar biologics by several manufacturers. Unlike generics, these are not identical to their innovator products because of the differences in the manufacturing process; however, they are similar in quality characteristics, biological activity, safety, and efficacy. The regulatory procedures used for generic drugs cannot be applied for biosimilars as they are large complex structures produced from living cells and can produce potential risk of immune-based adverse reactions. Out of several safety issues related to biosimilars, two main safety concerns are variable potency and immunogenicity, for which a robust long-term pharmacovigilance system is needed. Various guidelines have been issued for the regulatory approval and pharmacovigilance of biosimilars by USFDA, EU, and pharma-emerging countries like China and India. The article includes the pharmacovigilance plan of biosimilars in these countries, discusses the challenges and opportunities in pharmacovigilance through spontaneous reporting systems, and suggests amendments in the existing suspected adverse event reporting form of the Pharmacovigilance Programme of India.
Cultural Differences in Management: Two Aspects
Authors: De Gersem Nele
Published: September 2019

Indian companies have become very important in the global business world. Since the 1990s, this fact has received increasing attention from researchers, popular writers and consultants. Besides legal issues and economic facts, cultural difference is a recurring item in this literature. More specifically, the focus is on the Indianness of the Indian way of doing business. This article is a first step towards the process of examining two of the alleged aspects of this Indianness—one is paternalism and the other is hierarchy.
The Resident VIEW in Nursing Homes
Authors: White Diana L. , Tunalilar Ozcan , Hasworth Serena , Winfree Jaclyn
Published: September 2019

This article presents the Resident VIEW (Voicing Importance, Experience, and Well-Being), a measure designed to learn directly from long-term care residents the extent to which they experience support that matters most to them. The Resident VIEW contains 63 items across eight domains developed through cognitive interviews with residents in different types of residential settings (e.g., nursing homes, assisted living, and adult foster care). Residents rate items on both importance and their experience. In total, 258 nursing home residents living in 32 Oregon nursing homes were selected through a two-stage random sampling design and participated in the study. Results demonstrate that what matters most to residents varies, emphasizing the value of asking residents directly about their preferences. The relationship between importance and experience differed by item. Residents who experienced support rated very important within some domains, reported better quality of life and reported lower levels of depressive symptoms than those who did not experience these things. The interaction between importance and experience, however, did not reach statistical significance, suggesting that positive experiences may provide benefit even in some areas that are not perceived as important by residents. Results underscore the value of incorporating the resident perspective into measure development in long-term care.
Presenting Ethnicity: Israeli Citizenship Discourse
Authors: Herzog Ben
Published: September 2019

In 1950, Israel enacted the Law of Return and 2 years afterwards passed its Citizenship Law. These measures reflected the Zionist goal of encouraging Jewish immigration to Israel/Palestine, so citizenship was mostly limited to Jews. In other words, an ascriptive/ethnic classification was at the foundation of Israeli citizenship. This article explores the construction of the citizenship laws in relation to various forms of categorization—biological descent, cultural belonging, racial classifications, and voluntary affiliation. It asks how the Israeli citizenship policy was presented and which mechanisms were employed in order to justify the incorporation of all Jews, including those from Arab countries, while attempting to exclude non-Jews. After analyzing official state policies and parliamentary debates in Israel regarding the citizenship laws, I present the mechanisms employed to present the ethnic immigration policy. Those mechanisms include emphasizing the positive and democratic sides of allowing Jewish immigration; repeatedly avoiding the usage of racial terminology; highlighting the willingness to incorporate non-Jewish residents; and employing security justifications when prohibiting non-Jewish immigration. Being the Jewish State, Israel wanted to favor Jews in its immigration and naturalization policies. However, being also committed to democratic values and principles, it desired to disassociate itself from racial attitudes.
Mutant calreticulin in myeloproliferative neoplasms
Authors: How Joan , Hobbs Gabriela S. , Mullally Ann
Published: September 2019

In a Blood Spotlight that is also this month’s CME article, the authors review the current understanding of the biology underpinning mutant CALR-driven myeloproliferative neoplasms, discuss its clinical implications, and highlight future therapeutic approaches.
Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry
Authors: Amador Catalina , Greiner Timothy C. , Heavican Tayla B. , Smith Lynette M. , Galvis Karen Tatiana , Lone Waseem , Bouska Alyssa , D’Amore Francesco , Pedersen Martin Bjerregaard , Pileri Stefano , Agostinelli Claudio , Feldman Andrew L. , Rosenwald Andreas , Ott German , Mottok Anja , Savage Kerry J. , de Leval Laurence , Gaulard Philippe , Lim Soon Thye , Ong Choon Kiat , Ondrejka Sarah L. , Song Joo , Campo Elias , Jaffe Elaine S. , Staudt Louis M. , Rimsza Lisa M. , Vose Julie , Weisenburger Dennis D. , Chan Wing C. , Iqbal Javeed
Published: September 2019

One-third of peripheral T-cell lymphomas are “not otherwise specified” (PTCL-NOS), but they have been subdivided into 2 subgroups based on gene expression profiling. Amador and colleagues generated an immunohistochemical algorithm that parallels the molecular separation of PTCL-NOS and provides useful prognostic information.
First record of translocation in Culicidae (Diptera) mitogenomes: evidence from the tribe Sabethini
Authors: Lorenz Camila , Alves João Marcelo Pereira , Foster Peter Gordon , Sallum Maria Anice Mureb , Suesdek Lincoln
Published: September 2019

Background

The tribe Sabethini (Diptera: Culicidae) contains important vectors of the yellow fever virus and presents remarkable morphological and ecological diversity unequalled in other mosquito groups. However, there is limited information about mitochondrial genomes (mitogenomes) from these species. As mitochondrial genetics has been fundamental for posing evolutionary hypotheses and identifying taxonomical markers, in this study we sequenced the first sabethine mitogenomes: Sabethes undosus, Trichoprosopon pallidiventer, Runchomyia reversa, Limatus flavisetosus, and Wyeomyia confusa. In addition, we performed phylogenetic analyses of Sabethini within Culicidae and compared its mitogenomic architecture to that of other insects.

Results

Similar to other insects, the Sabethini mitogenome contains 13 protein-coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and a control region. However, the gene order is not the same as that in other mosquitoes; the tyrosine (Y) and cysteine (C) tRNA genes have translocated. In general, mitogenome rearrangements within insects are uncommon events; the translocation reported here is unparalleled among Culicidae and can be considered an autapomorphy for the Neotropical sabethines.

Conclusions

Our study provides clear evidence of gene rearrangements in the mitogenomes of these Neotropical genera in the tribe Sabethini. Gene order can be informative at the taxonomic level of tribe. The translocations found, along with the mitogenomic sequence data and other recently published findings, reinforce the status of Sabethini as a well-supported monophyletic taxon. Furthermore, T. pallidiventer was recovered as sister to R. reversa, and both were placed as sisters of other Sabethini genera (Sabethes, Wyeomyia, and Limatus).
Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma
Authors: Yan Tao , Liu Fang , Gao Jiajia , Lu Haizhen , Cai Jianqiang , Zhao Xiaohang , Sun Yulin
Published: September 2019

Background

Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis. However, its expression, regulation and clinical significance have not been systematically evaluated in a large number of clinical samples.

Methods

Here, we performed a comprehensive analysis of RUVBL2 based on multiple datasets from 371 liver cancer patients of The Cancer Genome Atlas (TCGA) and on immunohistochemical staining in 153 subjects. In addition, the aberrant signaling pathways caused by RUVBL2 overexpression were investigated.

Results

We demonstrated that promoter hypomethylation, copy number gain, MYC amplification and CTNNB1 mutation were all responsible for RUVBL2 overexpression in HCC. High levels of RUVBL2 mRNA were associated with shorter recurrence-free survival time (RFS) but not overall survival time (OS). Furthermore, RUVBL2 protein was overexpressed in the nucleus and cytoplasm of HCC samples. Univariate and multivariate survival analyses showed that strong nuclear and cytoplasmic staining of RUVBL2 independently predicted worse OS and RFS with a 2.03-fold and a 1.71-fold increase in the hazard ratio, respectively. High levels of RUVBL2 promoted carcinogenesis through the heat shock protein 90 (HSP90)-Cell Division Cycle 37 (CDC37), AKT serine/threonine kinase (AKT) and mitogen-activated protein kinase (ERK/MAPK) pathways.

Conclusion

The deregulation of RUVBL2 in HCC is influenced at the genomic, epigenetic and transcriptional levels. Our findings highlight the potential roles of RUVBL2 as a promising prognostic marker as well as a therapeutic target for HCC.
Generalized k-fractional integral inequalities associated with $(\alpha ,m)$-convex functions
Authors: Kang S. M. , Farid G. , Waseem M. , Ullah S. , Nazeer W. , Mehmood S.
Published: September 2019

This research investigates bounds of the sum of left-sided and right-sided fractional integrals in a compact form. These bounds are established by using $(\alpha ,m)$
(
α
,
m
)
-convex functions. The results of this paper also have connection with some known and already published results (Dragomir and Agarwal in Appl. Math. Lett. 11(5):91–95, 1998; Farid in J. Anal. 2018, https://doi.org/10.1007/s41478-0079-4; Farid et al. in Mathematics 2018(6):248, 2018). Moreover, the investigated results are applied to the end points as well as the mid point of the domain and some interesting consequences have been obtained.
Enabling architecture based Co-Simulation of complex Smart Grid applications
Authors: Binder Christoph , Fischinger Michael , Altenhuber Lukas , Draxler Dieter , Lastro Goran , Neureiter Christian
Published: September 2019

The integration of decentralized prosumers into current energy systems leads to continuously increasing complexity in today‘s popular term of the Smart Grid. Since conventional engineering methods reach their limits when dealing with the challenges in developing such systems, model-driven approaches like Domain Specific Systems Engineering (DSSE) gain significant importance. Contributing to the agile development of such a System of Systems (SoS), the application of the DSSE approach is furthermore supported by the introduction of the Smart Grid Architecture Model (SGAM) and Mosaik. However, with both concepts being individual methodologies, their interconnection is missing specifications. Therefore, this paper proposes the development of an interface between architecting and simulating a complex Smart Grid. To achieve this, the concepts of SGAM and Mosaik are analyzed in the first place in order to set up a suitable architectural model of an energy system and the corresponding simulation scenario. Subsequently, the applicability of the present approach is demonstrated by utilizing an excerpt of a real-world case study, the charging behavior of an Electric Vehicle (EV).