bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological and genetic heterogeneity of synchronous multifocal lung adenocarcinoma in a Chinese cohort
Authors: Zhu Donglin , Cao Dan , Shen Minghong , Lv Jinghuan
Published: February 2021

Background

Synchronous multifocal lung cancer (SMLC) is diagnosed with increasing frequency in clinical practice globally. Due to innate variation in clinical management and outcome, it is vital to properly distinguish between synchronous multifocal primary lung cancer (SMPLC) and intrapulmonary metastasis (IM). The pathologic features and principal classification criteria of multifocal lung cancer remain unclear. Our objective was to evaluate the diagnostic value of histological morphologic features and driver gene mutations in SMLC classification.

Methods

We collected a unique cohort of Chinese patients with SMLC, and fully explored the morphologic, immunohistochemical, and molecular features of the disease. Twenty-one SMLC patients with a total of 50 tumours were included in our study. The pathological features that were presented by these patients were analysed, including the tumours location, tumours size, pathological types, predominant pattern of adenocarcinoma, and immunohistochemical staining. We conducted molecular testing of nine driver oncogenes that are associated with lung cancer, namely, EGER, KRAS, BRAF, NRAS, ALK, ROS1, RET, HER2, and PIK3CA.

Results

According to the Martini-Melamed classification and refined standard, 8 and 17 patients, respectively, were considered to have SMPLCs. Gene mutations were identified in 18 tumours (36%). Twelve patients had different gene mutations.

Conclusions

We demonstrate that conventional morphological assessment is not sufficient to clearly establish the clonal relationship of SMPLCs. Instead, the evaluation of histological subtypes, including nonmucinous adherent components, is required. Multiplex genotypic analysis may also prove to be a useful additional tool.
Comparison of clinical outcome of decompression of suprascapular nerve at spinoglenoid notch for patients with posterosuperior massive rotator cuff tears and suprascapular neuropathy
Authors: Yang Pu , Wang Chen , Zhang Dongfang , Zhang Yi , Yu Tengbo , Qi Chao
Published: February 2021

Purpose

In the present study, we aimed to determine whether decompression of suprascapular nerve (SSN) at the spinoglenoid notch could lead to a better functional outcome for the patients who underwent repairment of rotator cuff due to posterosupeior massive rotator cuff tear (MRCT) and suprascapular neuropathy.

Methods

A total of 20 patients with posterosuperior MRCT and suprascapular neuropathy were analyzed in the present work. The preoperative magnetic resonance imaging (MRI) showed rotator cuff tear in supraspinatus and infraspinatus. All patients underwent arthroscopic rotator cuff repair. Patients were divided into two groups (group A: non-releasing, group B: releasing) according to whether the SSN at the spinoglenoid notch was decompressed. The modified University of California at Los Angeles shoulder rating scale (UCLA) and visual analog scale (VAS) questionnaire were adopted to assess the function of the affected shoulder preoperatively and 12 months after the operation. Electromyography (EMG) and nerve conduction study (NCS) were used to evaluate the nerve condition. Patients underwent MRI and EMG/NCS at 6 months after operation and last follow-up.

Results

All patients were satisfied with the treatment. MRI showed that it was well-healed in 19 patients at 6 months after the operation. However, the fatty infiltration of supraspinatus and infraspinatus was not reversed. Only one patient in the non-releasing group showed the retear. The retear rate of group A and group B were 30% (3/10) and 20% (2/10) respectively at 12 months after the operation. One patient undergoing SSN decompression complained of discomfort in the infraspinatus area. His follow-up EMG after 6 months showed fibrillation potentials (1+) and positive sharp waves (1+) in the infraspinatus. The other patients’ EMG results showed no abnormality. The postoperative UCLA and VAS scores were improved in both groups, and there was no significant difference in the follow-up outcomes between the two groups.

Conclusions

Patients with postersuperior MRCT and suprascapular neuropathy, decompression of suprascapular nerve at spinoglenoid notch didn’t lead to a better functional outcome with the repairment of rotator cuff. Arthroscopic rotator cuff repair could reverse the suprascapular neuropathy.

Level of evidence

Level III.
Commentary on two recently published formal guidelines on management of “mosaic” embryos after preimplantation genetic testing for aneuploidy (PGT-A)
Authors:   on behalf of the International Do No Harm Group in IVF (IDNHG-IVF), Gleicher Norbert , Barad David H. , Ben-Rafael Zion , Glujovsky Demian , Mochizuki Lyka , Modi Deepak , Murtinger Maximillian , Patrizio Pasquale , Orvieto Raoul , Takahashi Shizuko , Weghofer Andrea , Ziebe Søren
Published: February 2021

Two professional societies recently published opinions on the clinical management of “mosaic” results from preimplantation genetic testing for aneuploidy (PGT-A) in human blastocyst-stage embryos in associations with in vitro fertilization (IVF). We here point out three principal shortcomings: (i) Though a most recent societal opinion states that it should not be understood as an endorsement of the use of PGT-A, any discussion of how PGT-A should be clinically interpreted for all practical purposes does offer such an endorsement. (ii) The same guideline derived much of its opinion from a preceding guidance in favor of utilization of PGT-A that did not follow even minimal professional requirements for establishment of practice guidelines. (iii) Published guidelines on so-called “mosaic” embryos from both societies contradict basic biological characteristics of human preimplantation-stage embryos. They, furthermore, are clinically unvalidated and interpret results of a test, increasingly seen as harmful to IVF outcomes for many infertile women. Qualified professional organizations, therefore, should finally offer transparent guidelines about the utilization of PGT-A in association with IVF in general.
A mathematical model of circadian rhythms and dopamine
Authors: Kim Ruby , Reed Michael C.
Published: February 2021

Background

The superchiasmatic nucleus (SCN) serves as the primary circadian (24hr) clock in mammals and is known to control important physiological functions such as the sleep-wake cycle, hormonal rhythms, and neurotransmitter regulation. Experimental results suggest that some of these functions reciprocally influence circadian rhythms, creating a highly complex network. Among the clock’s downstream products, orphan nuclear receptors REV-ERB and ROR are particularly interesting because they coordinately modulate the core clock circuitry. Recent experimental evidence shows that REV-ERB and ROR are not only crucial for lipid metabolism but are also involved in dopamine (DA) synthesis and degradation, which could have meaningful clinical implications for conditions such as Parkinson’s disease and mood disorders.

Methods

We create a mathematical model consisting of differential equations that express how the circadian variables are influenced by light, how REV-ERB and ROR feedback to the clock, and how REV-ERB, ROR, and BMAL1-CLOCK affect the dopaminergic system. The structure of the model is based on the findings of experimentalists.

Results

We compare our model predictions to experimental data on clock components in different light-dark conditions and in the presence of genetic perturbations. Our model results are consistent with experimental results on REV-ERB and ROR and allow us to predict the circadian variations in tyrosine hydroxylase and monoamine oxidase seen in experiments. By connecting our model to an extant model of dopamine synthesis, release, and reuptake, we are able to predict circadian oscillations in extracellular DA and homovanillic acid that correspond well with experimental observations.

Conclusions

The predictions of the mathematical model are consistent with a wide variety of experimental observations. Our calculations show that the mechanisms proposed by experimentalists by which REV-ERB, ROR, and BMAL1-CLOCK influence the DA system are sufficient to explain the circadian oscillations observed in dopaminergic variables. Our mathematical model can be used for further investigations of the effects of the mammalian circadian clock on the dopaminergic system. The model can also be used to predict how perturbations in the circadian clock disrupt the dopaminergic system and could potentially be used to find drug targets that ameliorate these disruptions.
Unpacking the intention to action gap: a qualitative study understanding how physicians engage with audit and feedback
Authors: Desveaux Laura , Ivers Noah Michael , Devotta Kim , Ramji Noor , Weyman Karen , Kiran Tara
Published: February 2021

Background

Audit and feedback (A&F) often successfully enhances health professionals’ intentions to improve quality of care but does not consistently lead to practice changes. Recipients often cite data credibility and limited resources as barriers impeding their ability to act upon A&F, suggesting the intention-to-action gap manifests while recipients are interacting with their data. While attention has been paid to the role feedback and contextual variables play in contributing to (or impeding) success, we lack a nuanced understanding of how healthcare professionals interact with and process clinical performance data.

Methods

We used qualitative, semi-structured interviews guided by Normalization Process Theory (NPT). Questions explored the role of data in quality improvement, experiences with the A&F report, perceptions of the data, and interpretations and reflections. Interviews were audio-recorded and transcribed verbatim. Data were analyzed using a combination of inductive and deductive strategies using reflexive thematic analysis informed by a constructivist paradigm.

Results

Healthcare professional characteristics (individual quality improvement capabilities and beliefs about data) seem to influence engagement with A&F to a greater degree than feedback variables (i.e., delivered by peers) and observed contextual factors (i.e., strong quality improvement culture). Most participants lacked the capabilities to interpret practice-level data in an actionable way despite a motivation to engage meaningfully. Reasons for the intention-to-action gap included challenges interpreting longitudinal data, appreciating the nuances of common data sources, understanding how aggregate data provides insights into individualized care, and identifying practice-level actions to improve quality. These factors limited effective cognitive participation and collective action, as outlined in NPT.

Conclusions

A well-designed A&F intervention is necessary but not sufficient to inform practice changes. A&F initiatives must include co-interventions to address recipient characteristics (i.e., beliefs and capabilities) and context to optimize impact. Effective strategies to overcome the intention-to-action gap may include modelling how to use A&F to inform practice change, providing opportunities for social interaction relating to the A&F, and circulating examples of effective actions taken in response to A&F. More broadly, undergraduate medical education and post-graduate training must ensure physicians are equipped with QI capabilities, with an emphasis on the skills required to interpret and act on practice-level data.
Recent and massive invasion of Aedes (Stegomyia) albopictus (Skuse, 1894) in Phnom Penh, Cambodia
Authors: Maquart P. O. , Fontenille D. , Boyer S.
Published: February 2021

Graphical Abstract
Radiology residency training in China: results from the first retrospective nationwide survey
Authors: Zhang Jingfeng , Han Xinxin , Yang Zhenghan , Wang Zhenchang , Zheng Jianjun , Yang Zimo , Zhu Jiming
Published: February 2021

Objectives

This was the first study to systematically landscape and examine China’s nationwide standardized residency training in radiology.

Methods

In this retrospective cross-sectional study, we used data from the 2019 national survey of the first two cohorts of 3679 radiology residents who completed training in 2017 and 2018 across all 31 provinces in China. A total of 1163 (32%) residents participated in the survey. Multivariable logistic regression was used to examine the implementation frequency of 24 identified training tasks (categorized into six competencies) by region, demographics, and other residency information.

Results

Among the 1163 respondents, 592 (51%) were trained in the more developed eastern region. Of the 24 identified training tasks, 15 were implemented significantly differently across regions, while the frequency of the most frequently conducted tasks (e.g., CT, MR, and radiograph interpretation and reporting) was consistent. The top 10 tasks all fell into the patient care and medical knowledge competency domains, while other competencies tended to be neglected. We found region and marital status were the most influential factors of training task implementation frequencies. Respondents trained in the northeast and the west were more likely to report, for instance, radiological examination recommendation (OR = 1.91, 95%CI = 1.27–2.88), as “very frequent.” Married respondents were more likely to report first-line night shift as “very frequent” (OR = 1.71, 95%CI = 1.29–2.26).

Conclusions

Despite the fast-win achievements of developing a national radiology residency training program, there is a gap to train quality and homogeneous radiologists across regions. Future improvement should be more tailored to residents’ personal characteristics and emphasize some “soft” competencies (e.g., communication skills).
Mathematical analysis of a within-host model of SARS-CoV-2
Authors: Nath Bhagya Jyoti , Dehingia Kaushik , Mishra Vishnu Narayan , Chu Yu-Ming , Sarmah Hemanta Kumar
Published: February 2021

In this paper, we have mathematically analyzed a within-host model of SARS-CoV-2 which is used by Li et al. in the paper “The within-host viral kinetics of SARS-CoV-2” published in (Math. Biosci. Eng. 17(4):2853–2861, 2020). Important properties of the model, like nonnegativity of solutions and their boundedness, are established. Also, we have calculated the basic reproduction number which is an important parameter in the infection models. From stability analysis of the model, it is found that stability of the biologically feasible steady states are determined by the basic reproduction number $(\chi _{0})$
(

χ
0

)
. Numerical simulations are done in order to substantiate analytical results. A biological implication from this study is that a COVID-19 patient with less than one basic reproduction ratio can automatically recover from the infection.
Polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths in school-aged children in Muyuka–Cameroon following implementation of control measures: a cross sectional study
Authors: Sumbele Irene Ule Ngole , Otia Ofon Vitalis , Bopda Orelien Sylvain Mtopi , Ebai Calvin Bisong , Kimbi Helen KuoKuo , Nkuo-Akenji Theresa
Published: February 2021

Background

Despite the ubiquity of polyparasitism, its health impacts have been inadequately studied. The aim of this study was to determine the prevalence and determinants of polyparasitism with Schistosoma haematobium, Plasmodium and soil-transmitted helminths (STH) following sustained control measures, as well as evaluate the outcomes and clinical correlates of infection in school-aged children (SAC) living in the schistosomiasis endemic focus of Muyuka-Cameroon.

Methods

In a cross-sectional study, urine, blood and stool samples were each collected from SAC (4–14 years) selected at random between March and June 2015. Microhaematuria in urine was detected using reagent strip and S. haematobium ova by filtration/microscopy methods. Plasmodium was detected using Giemsa-stained blood films and complete blood count was obtained using an auto-haematology analyser. STH in stool was detected by the Kato-Katz method. Categorical and continuous variables were compared as required, Kappa value estimated and the adjusted odds ratio (aOR) in the multivariate analysis was used to evaluate association of the risk factors with infection.

Results

Out of the 638 SAC examined, single infection was prevalent in 33.4% while polyparasitism was 19.9%. Prevalence of S. haematobium + Plasmodium was 7.8%; S. haematobium + STH was 0.8%; Plasmodium + STH was 0.8%; while S. haematobium + Plasmodium + STH was 0.9%. Higher preponderance of S. haematobium + Plasmodium infection occurred in females, those from Likoko, did not use potable water, practiced bathing in stream and carried out open defecation than their equivalents. However, being female (aOR = 2.38, P = 0.009) was the only significant risk factor identified. Anaemia was a common morbidity (74.3%) with a slight agreement with microscopy in predicting S. haematobium and Plasmodium infections. The sensitivity and specificity of haematuria (13.0%) in predicting S. haematobium infection was 46.5% and 100% with a moderate agreement with microscopy. Co-infection with S. haematobium and malaria parasite was significantly associated with threefold odds of history of fever in the last three days.

Conclusions

Polyparasitism is a public health problem in Muyuka with females most at risk. Anaemia prevalence is exacerbated in co- and triple-infections and together with a history of fever are of value in predicting polyparasitism.
Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice
Authors: Hagio Soichiro , Tsuji Naho , Furukawa Satoshi , Takeuchi Kazuya , Hayashi Seigo , Kuroda Yusuke , Honma Masamitsu , Masumura Kenichi
Published: February 2021

Background

Acrylamide (AA) is a rodent carcinogen and classified by the IARC into Group 2A (probable human carcinogen). AA has been reported to induce mutations in transgenic rodent gene mutation assays (TGR assays), the extent of which is presumed to depend on exposure length and the duration of expression after exposure. In particular, it is not clear in germ cells. To investigate mutagenicity with AA in somatic and germ cells at different sampling times, we conducted TGR assays using gpt delta transgenic mice.

Results

The male gpt delta mice at 8 weeks of age were treated with AA at 7.5, 15 and 30 mg/kg/day by gavage for 28 days. Peripheral blood was sampled on the last day of the treatment for micronucleus tests and tissues were sampled for gene mutation assays at day 31 and day 77, those being 3 and 49 days after the final treatment (28 + 3d and 28 + 49d), respectively. Another group of mice was treated with N-Ethyl-N-nitrosourea (ENU) at 50 mg/kg/day by intraperitoneal administration for 5 consecutive days and tissues were sampled at the day 31 and day 77 (5 + 26d and 5 + 72d). Frequencies of micronucleated erythrocytes in the peripheral blood significantly increased at AA doses of 15 and 30 mg/kg/day. Two- to three-fold increases in gpt mutation frequencies (MFs) compared to vehicle control were observed in the testes and lung treated with 30 mg/kg/day of AA at both sampling time. In the sperm, the gpt MFs and G:C to T:A transversions were significantly increased at 28 + 3d, but not at 28 + 49d. ENU induced gpt mutations in these tissues were examined at both 5 + 26d and 5 + 72d. A higher mutant frequency in the ENU-treated sperm was observed at 5 + 72d than that at 5 + 26d.

Conclusions

The gpt MFs in the testes, sperm and lung of the AA-treated mice were determined and compared between different sampling times (3 days or 49 days following 28 day-treatment). These results suggest that spermatogonial stem cells are less sensitive to AA mutagenicity under the experimental condition. Prolonged expression time after exposure to AA to detect mutagenicity may be effective in somatic cells but not in germ cells.
Friston's free energy principle: new life for psychoanalysis?
Authors: Holmes Jeremy
Published: February 2021

The free energy principle (FEP) is a new paradigm that has gain widespread interest in the neuroscience community. Although its principal architect, Karl Friston, is a psychiatrist, it has thus far had little impact within psychiatry. This article introduces readers to the FEP, points out its consilience with Freud's neuroscientific ideas and with psychodynamic practice, and suggests ways in which the FEP can help explain the mechanisms of action of the psychotherapies.
Development and Validation of Nomograms to Predict Local, Regional, and Distant Recurrence in Patients With Thin (T1) Melanomas
Authors: El Sharouni Mary-Ann , Ahmed Tasnia , Varey Alexander H. R. , Elias Sjoerd G. , Witkamp Arjen J. , Sigurdsson Vigfús , Suijkerbuijk Karijn P. M. , van Diest Paul J. , Scolyer Richard A. , van Gils Carla H. , Thompson John F. , Blokx Willeke A. M. , Lo Serigne N.
Published: February 2021

PURPOSE

Although the prognosis of patients with thin primary cutaneous melanomas (T1, ≤ 1.0 mm) is generally excellent, some develop recurrence. We sought to develop and validate a model predicting recurrences in patients with thin melanomas.

METHODS

A Dutch population-based cohort (n = 25,930, development set) and a cohort from an Australian melanoma treatment center (n = 2,968, validation set) were analyzed (median follow-up 6.7 and 12.0 years, respectively). Multivariable Cox models were generated for local, regional, and distant recurrence-free survival (RFS). Discrimination was assessed using Harrell's C-statistic for each outcome. Each nomogram performance was evaluated using calibration plots defining low-risk and high-risk groups as the lowest and top 5% of the nomogram risk score, respectively. The nomograms' C-statistics were compared with those of a model including the current American Joint Committee on Cancer staging parameters (T-stage and sentinel node status).

RESULTS

Local, regional, and distant recurrences were found in 209 (0.8%), 503 (1.9%), and 203 (0.8%) Dutch patients, respectively, and 23 (0.8%), 61 (2.1%), and 75 (2.5%) Australian patients, respectively. C-statistics of 0.79 (95% CI, 0.75 to 0.82) for local RFS, 0.77 (95% CI, 0.75 to 0.78) for regional RFS, and 0.80 (95% CI, 0.77 to 0.83) for distant RFS were obtained for the development model. External validation showed C-statistics of 0.80 (95% CI, 0.69 to 0.90), 0.76 (95% CI, 0.70 to 0.82), and 0.74 (95% CI, 0.69 to 0.80), respectively. Calibration plots showed a good match between predicted and observed rates. Using the nomogram, the C-statistic was increased by 9%-12% for the development cohort and by 11%-15% for the validation cohort, compared with a model including only T-stage and sentinel node status.

CONCLUSION

Most patients with thin melanomas have an excellent prognosis, but some develop recurrence. The presented nomograms can accurately identify a subgroup at high risk. An online calculator is available at www.melanomarisk.org.au .
At the Door of the Theater: Kafka’s Oklahama Theater and the Nature Theater Movement
Authors: Grøtta Marit
Published: February 2021

The Nature theater of Oklahama in Der Verschollene is one of Kafka’s most enigmatic inventions, widely known through Walter Benjamin’s and Giorgio Agamben’s reading of it as a theater of gestures. This article explores the intertextual archive of Kafka’s novel, bringing into play an entry hitherto overlooked: the nature theater movement in the early twentieth century, promoted by the conservative Heimatkunstbewegung. Discussing the historical nature theater, on the one hand, and Benjamin’s and Agamben’s theater of gestures, on the other, the article examines the conceptions of life that come into play in the novel (life as career, life as theater, life as gesture) and considers the fate of the protagonist in this light. Seeing the question of inclusion/exclusion as key to Kafka’s novel, the article argues that it exposes the thin line between utopia and dystopia and allows us to reflect on the dangers as well as the possibilities of modernity.
Structured Robust Submodular Maximization: Offline and Online Algorithms
Authors: Torrico Alfredo , Singh Mohit , Pokutta Sebastian , Haghtalab Nika , Naor Joseph (Seffi) , Anari Nima
Published: February 2021

Constrained submodular function maximization has been used in subset selection problems such as selection of most informative sensor locations. Although these models have been quite popular, the solutions obtained via this approach are unstable to perturbations in data defining the submodular functions. Robust submodular maximization has been proposed as a richer model that aims to overcome this discrepancy as well as increase the modeling scope of submodular optimization. In this work, we consider robust submodular maximization with structured combinatorial constraints and give efficient algorithms with provable guarantees. Our approach is applicable to constraints defined by single or multiple matroids and knapsack as well as distributionally robust criteria. We consider both the offline setting where the data defining the problem are known in advance and the online setting where the input data are revealed over time. For the offline setting, we give a general (nearly) optimal bicriteria approximation algorithm that relies on new extensions of classical algorithms for submodular maximization. For the online version of the problem, we give an algorithm that returns a bicriteria solution with sublinear regret.

Summary of Contribution: Constrained submodular maximization is one of the core areas in combinatorial optimization with a wide variety of applications in operations research and computer science. Over the last decades, both communities have been interested on the design and analysis of new algorithms with provable guarantees. Sensor location, influence maximization and data summarization are some of the applications of submodular optimization that lie at the intersection of the aforementioned communities. Particularly, our work focuses on optimizing several submodular functions simultaneously. We provide new insights and algorithms to the offline and online variants of the problem which significantly expand the related literature. At the same time, we provide a computational study that supports our theoretical results.
Deferred Acceptance with Compensation Chains
Authors: Dworczak Piotr
Published: February 2021

In a foundational paper, Gale and Shapley (1962) introduced the deferred acceptance algorithm that achieves a stable outcome in a two-sided matching market by letting one side of the market make proposals to the other side. What happens when both sides of the market can propose? In “Deferred Acceptance with Compensation Chains,” Dworczak answers this question by constructing an equitable version of the Gale–Shapley algorithm in which the sequence of proposers can be arbitrary. The main result of the paper shows that the extended algorithm, equipped with so-called compensation chains, is not only guaranteed to converge in polynomial time to a stable outcome, but—in contrast to the original Gale–Shapley algorithm—achieves all stable matchings (as the sequence of proposers vary). The proof of convergence uses a novel potential function. The algorithm may find applications in settings where both stability and fairness are desirable features of the matching process.
CAOS spectral imager design and advanced high dynamic range FDMA–TDMA CAOS mode
Authors: Mazhar Mohsin A. , Riza Nabeel A.
Published: February 2021

A CAOS line camera is introduced for spectral imaging of one-dimensional (1D) or line targets. The proposed spectral camera uses both a diffraction grating as well as a cylindrical lens optics system to provide line imaging along the line pixels’ direction of the image axis and Fourier transform operations in the orthogonal direction to provide optical spectrum analysis of the line pixels. The imager incorporates a coded access optical sensor (CAOS) structure based on a digital micromirror device (DMD). The design includes a line-by-line scan option to enable 2D spectral imaging. Line style spectral imaging using a 2850 K color temperature white light target illumination source along with visible band color bandpass filters and a moving mechanical pinhole is demonstrated for the first time, to the best of our knowledge, to simulate a line target with individual pixels in 1D that have unique spectral content. A 

∼

412

to

∼

732

n
m

input target spectrum is measured using a

38

×
52

CAOS pixel spatial sampling grid providing a test image line of 38 pixels, with each pixel providing a designed spectral resolution of

∼

6.2

n
m

. The spectral image is generated using the robust code division multiple access (CDMA) mode of the camera. Then, for what we believe is the first time, the high dynamic range (HDR) operation of the frequency division multiple access–time division multiple access (FDMA–TDMA) mode of the CAOS camera is demonstrated. The FDMA–TDMA mode also features HDR recovery like the frequency modulation TDMA (FM–TDMA) mode, although at a much faster imaging rate and a higher signal-to-noise ratio (SNR), as more than one CAOS pixel is extracted at a time. Experiments successfully demonstrate 66 dB HDR target recovery using both FDMA–TDMA and FM–TDMA modes, with the FDMA–TDMA mode operating at an encoding speed eight times faster than the FM–TDMA mode, given that eight FM channels are used for the FDMA–TDMA mode. The CAOS spectral imager can be used to image both full spectrum stationary line targets as well as spectrally map 2D targets using line scanning methods. The demonstrated FDMA–TDMA CAOS mode is suited for improved speed and SNR linear HDR imaging.
Analysis and removal of crosstalk in a time-multiplexed light-field display
Authors: Liu Boyang , Sang Xinzhu , Yu Xunbo , Ye Xiaoqian , Gao Xin , Liu Li , Gao Chao , Wang Peiren , Xie Xinhui , Yan Binbin
Published: February 2021

Time-multiplexed light-field displays (TMLFDs) can provide natural and realistic three-dimensional (3D) performance with a wide 120° viewing angle, which provides broad potential applications in 3D electronic sand table (EST) technology. However, current TMLFDs suffer from severe crosstalk, which can lead to image aliasing and the distortion of the depth information. In this paper, the mechanisms underlying the emergence of crosstalk in TMLFD systems are identified and analyzed. The results indicate that the specific structure of the slanted lenticular lens array (LLA) and the non-uniformity of the emergent light distribution in the lens elements are the two main factors responsible for the crosstalk. In order to produce clear depth perception and improve the image quality, a novel ladder-type LCD sub-pixel arrangement and a compound lens with three aspheric surfaces are proposed and introduced into a TMLFD to respectively reduce the two types of crosstalk. Crosstalk simulation experiments demonstrate the validity of the proposed methods. Structural similarity (SSIM) simulation experiments and light-field reconstruction experiments also indicate that aliasing is effectively reduced and the depth quality is significantly improved over the entire viewing range. In addition, a tabletop 3D EST based on the proposed TMLFD is presented. The proposed approaches to crosstalk reduction are also compatible with other lenticular lens-based 3D displays.
Waveguide-coupled superconducting nanowire single-photon detectors based on femtosecond laser direct writing
Authors: Hou Xintong , Xu Xiao-Yun , Xu Guangzhao , You Lixing , Jin Xian-Min , Li Hao , Zhang Weijun , Ren Ruo-Jing , Huang Xuan-Lun , Wang Zhen
Published: February 2021

The implementation of quantum information technologies requires the development of integrated quantum chips. Femtosecond laser direct writing (FLDW) waveguides and superconducting nanowire single-photon detectors (SNSPDs) have been widely applied in integrated quantum photonic circuits. In this work, a novel FLDW waveguide-coupled SNSPD was designed and realized by integrating FLDW waveguides and conventional SNSPDs together. Through a COMSOL simulation, a waveguide end face-nanowire optical coupling structure was designed and verified. The simulation results showed that the FLDW waveguide-coupled SNSPD device, which had a target wavelength of 780 nm, can achieve 87% optical absorption. Then the preparation process of the FLDW waveguide-coupled SNSPD device was developed, and the fabricated device achieved a system detection efficiency of 1.7% at 10 Hz dark count rate. Overall, this method provides a feasible single-photon detector solution for future on-chip integrated quantum photonic experiments and applications.
Near-infrared thermally modulated varifocal metalens based on the phase change material Sb2S3
Authors: Qin Shuai , Xu Ning , Huang Hui , Jie Kaiqian , Liu Hongzhan , Guo Jianping , Meng Hongyun , Wang Faqiang , Yang Xiangbo , Wei Zhongchao
Published: February 2021

Focus-tunable metalenses play an indispensable role in the development of integrated optical systems. In this paper, the phase change material Sb2S3 is used in a thermally modulated varifocal metalens based on PB-phase for the first time. Sb2S3 not only has a real part of refractive index shift between the amorphous and crystalline state but also has low losses in both amorphous and crystalline states in the near-infrared region. By switching Sb2S3 between the two states, a metalens doublet with a variable focal length is proposed. Moreover, the full width at half maximum of each focal point is close to the diffraction limit. And the focusing efficiency can be over 50% for the two focal points. Together with the advantage of precise thermal control, the proposed metalens has great potential in the application of multi-functional devices, biomedical science, communication and imaging.
Enhancing the efficiency of solution-processed inverted quantum dot light-emitting diodes via ligand modification with 6-mercaptohexanol
Authors: Lee Woosuk , Lee Changmin , Kim Boram , Choi Yonghyeok , Chae Heeyeop
Published: February 2021

In this Letter, the surface hydrophilicity of the quantum dot (QD) emitting layer (EML) was modified via a ligand exchange to prevent QD EML damage upon hole transport layer (HTL) deposition for all-solution-processed inverted QD-light-emitting diodes (QLEDs). The conventional hydrophobic oleic acid ligand (OA-QDs) was partially replaced with a hydrophilic 6-mercaptohexanol (OH-QDs) through a one-pot ligand exchange. Owing to this replacement, the contact angle of a water droplet on the OH-QD films was reduced to 71.7° from 89.5° on the OA-QD films, indicating the conversion to hydrophilic hydroxyl ligands. The OH-QD EML maintained its integrity without any noticeable damage, even after HTL deposition, enabling all-solution processing for inverted QLEDs with well-organized multilayers. Inverted QLEDs with the OH-QD EMLs were compared with those with OA-QD EMLs; the maximum current efficiency of the device with the OH-QD EML significantly improved to 39.0 cd

A

−
1

from 5.3 cd

A

−
1

, and the peak external quantum efficiency improved to 9.3% from 1.2%, which is a seven-fold increase over the OA-QD device. This approach is believed to be effective for forming solid QD films with resistance to chlorobenzene, a representative HTL solvent, and consequently contributes to high-efficiency all-solution-processed inverted QLEDs.
Modulation of MXene Nb2CTx saturable absorber for passively Q-switched 2.85 µm Er:Lu2O3laser
Authors: Feng Chenyang , Qiao Wenchao , Liu Yizhou , Huang Jiacheng , Liang Yangyang , Zhao Yuefeng , Song Yuzhi , Li Tao
Published: February 2021

We proposed a passively stabilized Q-switched

E
r

:

L
u

2

O

3

laser at 2845 nm, applying a MXene

N
b

2

C
T

x

nanosheets saturable absorber prepared by the liquid-phase exfoliation method. The surface morphology and nonlinear properties of this nanosheet were systematically characterized. Average output power of 542 mW for the Q-switched laser was obtained under 7.26 W of absorbed pump power. Meanwhile, the Q-switched pulse duration was measured to be 223.7 ns with 142.9 kHz repetition rate corresponding to a peak power of 16.96 W.
All-optical neuromorphic binary convolution with a spiking VCSEL neuron for image gradient magnitudes
Authors: Zhang Yahui , Robertson Joshua , Xiang Shuiying , Hejda Matěj , Bueno Julián , Hurtado Antonio
Published: February 2021

All-optical binary convolution with a photonic spiking vertical-cavity surface-emitting laser (VCSEL) neuron is proposed and demonstrated experimentally for the first time, to the best of our knowledge. Optical inputs, extracted from digital images and temporally encoded using rectangular pulses, are injected in the VCSEL neuron, which delivers the convolution result in the number of fast (

<
100
  
ps

long) spikes fired. Experimental and numerical results show that binary convolution is achieved successfully with a single spiking VCSEL neuron and that all-optical binary convolution can be used to calculate image gradient magnitudes to detect edge features and separate vertical and horizontal components in source images. We also show that this all-optical spiking binary convolution system is robust to noise and can operate with high-resolution images. Additionally, the proposed system offers important advantages such as ultrafast speed, high-energy efficiency, and simple hardware implementation, highlighting the potentials of spiking photonic VCSEL neurons for high-speed neuromorphic image processing systems and future photonic spiking convolutional neural networks.
Incoherent imaging through highly nonstatic and optically thick turbid media based on neural network
Authors: Zheng Shanshan , Wang Hao , Dong Shi , Wang Fei , Situ Guohai
Published: February 2021

Imaging through nonstatic scattering media is one of the major challenges in optics, and encountered in imaging through dense fog, turbid water, and many other situations. Here, we propose a method to achieve single-shot incoherent imaging through highly nonstatic and optically thick turbid media by using an end-to-end deep neural network. In this study, we use fat emulsion suspensions in a glass tank as a turbid medium and an additional incoherent light to introduce strong interference noise. We calibrate that the optical thickness of the tank of turbid media is as high as 16, and the signal-to-interference ratio is as low as

−
17
  
dB

. Experimental results show that the proposed learning-based approach can reconstruct the object image with high fidelity in this severe environment.
Brain-inspired model for early vocal learning and correspondence matching using free-energy optimization
Authors: Pitti Alexandre , Quoy Mathias , Boucenna Sofiane , Lavandier Catherine
Published: February 2021

We propose a developmental model inspired by the cortico-basal system (CX-BG) for vocal learning in babies and for solving the correspondence mismatch problem they face when they hear unfamiliar voices, with different tones and pitches. This model is based on the neural architecture INFERNO standing for Iterative Free-Energy Optimization of Recurrent Neural Networks. Free-energy minimization is used for rapidly exploring, selecting and learning the optimal choices of actions to perform (eg sound production) in order to reproduce and control as accurately as possible the spike trains representing desired perceptions (eg sound categories). We detail in this paper the CX-BG system responsible for linking causally the sound and motor primitives at the order of a few milliseconds. Two experiments performed with a small and a large audio database show the capabilities of exploration, generalization and robustness to noise of our neural architecture in retrieving audio primitives during vocal learning and during acoustic matching with unheared voices (different genders and tones).
The importance of the traditional milpa in food security and nutritional self-sufficiency in the highlands of Oaxaca, Mexico
Authors: Novotny Ivan P. , Tittonell Pablo , Fuentes-Ponce Mariela H. , López-Ridaura Santiago , Rossing Walter A. H.
Published: February 2021

Around 30% of global food is produced by smallholder farmers, yet they constitute the most food-insecure group. In Mexico, food self-sufficiency is declining. Rural policies in the country have stimulated the production of cash crops to the detriment of the traditional intercropping system, themilpa. Such a decline may have negative consequences for the food security of subsistence farmers. This study aimed to assess changes in nutritional self-sufficiency over the last 30 years and the role ofmilpasystems in food security for two communities in the highlands of Oaxaca, Mexico. The study used satellite images, censuses, and field data to estimate food production. Three cropping systems, monoculture of maize, monoculture of common bean, and themilpawere compared in terms of nutrients and vitamins produced. Furthermore, a household typology was developed for each community to contrast nutritional self-sufficiency levels between the different household types. Results showed that themilpaproduced more volume of food per area compared to the other systems. Themilpaalso produced all the nutrients and vitamins (except for B12) required to feed at least 2 persons ha-1. Monocultures of maize lacked vitamins A, B9, B12, and C, and the common bean lacked vitamins A, B12, and C. While farmers recognized the importance of themilpa, they preferred monocultures due to the reduced labor demands of this system. Households that obtained most of their income from off-farm activities had the lowest nutritional self-sufficiency. Enhancing nutritional self-sufficiency through crop diversification has the potential to not only improve the nutrition of subsistence farmers, but also to enhance ecosystem service provision, promote biodiversity conservation and restoration, and improve resilience to climate change.
Analysis of lung transcriptome in calves infected with Bovine Respiratory Syncytial Virus and treated with antiviral and/or cyclooxygenase inhibitor
Authors: Lebedev Maxim , McEligot Heather A. , Mutua Victoria N. , Walsh Paul , Carvallo Chaigneau Francisco R. , Gershwin Laurel J.
Published: February 2021

Bovine Respiratory Syncytial virus (BRSV) is one of the major infectious agents in the etiology of the bovine respiratory disease complex. BRSV causes a respiratory syndrome in calves, which is associated with severe bronchiolitis. In this study we describe the effect of treatment with antiviral fusion protein inhibitor (FPI) and ibuprofen, on gene expression in lung tissue of calves infected with BRSV. Calves infected with BRSV are an excellent model of human RSV in infants: we hypothesized that FPI in combination with ibuprofen would provide the best therapeutic intervention for both species. The following experimental treatment groups of BRSV infected calves were used: 1) ibuprofen day 3–10, 2) ibuprofen day 5–10, 3) placebo, 4) FPI day 5–10, 5) FPI and ibuprofen day 5–10, 6) FPI and ibuprofen day 3–10. All calves were infected with BRSV on day 0. Daily clinical evaluation with monitoring of virus shedding by qRT-PCR was conducted. On day10 lung tissue with lesions (LL) and non-lesional (LN) was collected at necropsy, total RNA extracted, and RNA sequencing performed. Differential gene expression analysis was conducted with Gene ontology (GO) and KEGG pathway enrichment analysis. The most significant differential gene expression in BRSV infected lung tissues was observed in the comparison of LL with LN; oxidative stress and cell damage was especially noticeable. Innate and adaptive immune functions were reduced in LL. As expected, combined treatment with FPI and Ibuprofen, when started early, made the most difference in gene expression patterns in comparison with placebo, especially in pathways related to the innate and adaptive immune response in both LL and LN. Ibuprofen, when used alone, negatively affected the antiviral response and caused higher virus loads as shown by increased viral shedding. In contrast, when used with FPI Ibuprofen enhanced the specific antiviral effect of FPI, due to its ability to reduce the damaging effect of prostanoids and oxidative stress.
Prevalence of malaria and associated factors among under-five children in Sherkole refugee camp, Benishangul-Gumuz region, Ethiopia. A cross-sectional study
Authors: Ahmed Abdulmuneim , Mulatu Kebadnew , Elfu Berhanu
Published: February 2021

Background

Under-five year children are the most vulnerable group affected by malaria, they accounted for 61% of all malaria deaths worldwide. Sherkole refugee camp is stratified under high risk for malaria. Knowledge on malaria prevalence and associated factors among under-five children in Sherkole refugee camp is lacking.

Methods and materials

Institution-based cross-sectional survey was conducted among under-five children in Sherkole refugee camp from October to November 2019. Total sample size was 356. Stratified random sampling technique was employed to select the study participants. Standardized questionnaire was used to collect data. Care StartTM Malaria Rapid diagnostic test which detect histidine-rich protein 2 of P. falciparum and plasmodium lactate dehydrogenase of P. vivax was used to diagnose malaria. Bivariate and multivariable logistic regression analysis was done to identify factors associated with malaria.

Results

A total of 356 participants were included in this study with response rate of 97.5%. The prevalence malaria was 3.9% (95% CI = 2.0–6.2). Outdoor stay at night (AOR = 3.9, 95% CI = 1.14–13.8), stagnant water near to house (AOR = 4.0, 95% CI = 1.14–14.6), and the number of under-five children per household (AOR = 3.0, 95% CI = 1.03–13.0) were found to increase the odds of getting malaria. Whereas, insecticide treated net (ITN)utilization (AOR = 0.22, 95% CI = 0.06–0.61) and Health information about malaria (AOR = 0.29, 95% CI = 0.06–0.65) reduce the odds of getting malaria.

Conclusions and recommendations

Malaria remains the major public health problem in Sherkole Refugee camp. Outdoor stay at night, stagnant water near to house, and number of under-five children per household were the risk factors for malaria. Health information dissemination that focuses on avoiding outdoor stay at night, eliminating stagnant water & using ITN, and considering number of under-five children per household during ITN distribution should be take into account.
Immunohistochemical identification of complement peptide C5a receptor 1 (C5aR1) in non-neoplastic and neoplastic human tissues
Authors: Nürge Benjamin , Schulz Alan Lennart , Kaemmerer Daniel , Sänger Jörg , Evert Katja , Schulz Stefan , Lupp Amelie
Published: February 2021

The complement component C5a and its receptor C5aR1 are involved in the development of numerous inflammatory diseases. In addition to immune cells, C5aR1 is expressed in neoplastic cells of multiple tumour entities, where C5aR1 is associated with a higher proliferation rate, advanced tumour stage, and poor patient outcomes. The aim of the present study was to obtain a broad expression profile of C5aR1 in human non-neoplastic and neoplastic tissues, especially in tumour entities not investigated in this respect so far. For this purpose, we generated a novel polyclonal rabbit antibody, {5227}, against the carboxy-terminal tail of C5aR1. The antibody was initially characterised in Western blot analyses and immunocytochemistry using transfected human embryonic kidney (HEK) 293 cells. It was then applied to a large series of formalin-fixed, paraffin-embedded non-neoplastic and neoplastic human tissue samples. C5aR1 was strongly expressed by different types of immune cells in the majority of tissue samples investigated. C5aR1 was also present in alveolar macrophages, bronchial, gut, and bile duct epithelia, Kupffer cells, occasionally in hepatocytes, proximal renal tubule cells, placental syncytiotrophoblasts, and distinct stem cell populations of bone marrow. C5aR1 was also highly expressed in the vast majority of the 32 tumour entities investigated, where a hitherto unappreciated high prevalence of the receptor was detected in thyroid carcinomas, small-cell lung cancer, gastrointestinal stromal tumours, and endometrial carcinomas. In addition to confirming published findings, we found noticeable C5aR1 expression in many tumour entities for the first time. Here, it may serve as an interesting target for future therapies.