bluuebunny/crossref_metadata_2025 huggingface dataset:
Holistic approach of Talent Management for a successful Succession Planning
Authors: Dr. Satuluri Padma Mukesh Mihir,
Published: March 2024

Preparing ourselves for future volatile economic environment is a challenge. Every Organization needs to develop a succession plan for taking up the roles and responsibility by the next generation leaders.  Indian Public Sectors Units (PSUs) often find themselves in a challenging situation while positioning suitable manpower for the key leadership positions in the changing market situation. They adopt several Management Practices to develop future leaders within the organization, as it is more preferable to develop a Talent Pool in-house, rather than acquiring it from outside. Based on various studies in the past, relationship between Succession planning and Talent Management is well established. Yet, the impact of Performance Management in particular, needs to be specifically addressed, critically analyzed and reviewed in depth in line with acquiring, developing and retaining the talent for a successful Succession Planning.

Problem statement - how does Performance Management System impact on Succession Planning? what is the relevance in integrating these two and how does it contribute to organizational sustainability? what are the Talent Management processes that support successful Succession Planning?

The study involves a sample of Indian PSUs from various sectors. A mixed method approach for data analysis is preferred. Document analysis involves review of Policy/guidelines, Procedures and Reports related to Human Resource Development (HRD); whereas feedback on perception of employees were collected through interactions with key stakeholders and analyzed using thematic analysis to identify linkage between Performance Management and Succession Planning.

The study suggests the holistic approach towards Talent Management and its best practices for a successful Succession Planning. It recommends to identify and develop individuals in-house, for the critical and key leadership roles thus achieving organizational sustainability.
Experimental Investigations and Qualification of Innovative Flow Sensors in the 1000 K SOLTEC-2 Sodium Loop
Authors: Onea Alexandru , Krauter Nico , Hering Wolfgang , Lenk Stephan , Ruck Sebastian , Stieglitz Robert , Gerbeth Gunter
Published: March 2024

Liquid metals, such as sodium, have been already successfully used as heat transfer fluids (HTF) in concentrating solar power (CSP) plants up to ~550 °C. Even higher temperatures can be achieved and are envisioned for future CSP plants. The lack of measuring flow rate devices at high temperatures for liquid metals motivated this study. The present paper presents the experimental mock-up and the experimental results obtained with the SOLTEC-2 facility for two test flow sensors, one innovative eddy current flow sensor (ECFM) developed at HZDR, Germany and a built-in permanent magnet fly-wheel sensor for runs up to a sodium temperature of 700 °C. The signals of the sensors are compared also against the power level of the sodium pump.
The phenomenological study on the experience of using a mobile mental health service platform based on SNS
Authors:   Korea Safety Culture Society, Lee Sol Ji
Published: March 2024

This study is a phenomenological study on the experience of using a mobile mental health service platform developed and provided by mental health social welfare experts, and was conducted to provide practical policy and practical suggestions for the necessity of a mobile mental health service platform and the use of a professional mobile mental health service platform in Korea's mental health service delivery system. To this study, data were collected from 12 research participants who have been continuously using the platform for more than a year, and the data were analyzed by applying Giorgi's phenomenological perspective to deeply analyze the nature and meaning of the experience of the phenomenon. As a result of the analysis, 7 components and 20 sub-components were derived, and the components were found to struggle in the beginning and despair of the problem, mental health services I used and negative memories, various mental health services experienced in accidental spaces, reasons for continuing to find the mobile mental health service platform, psychological stability and practical change and recovery, limitations of personal mobile mental health service platforms, and partnerships with public mental health services. Based on these analysis results, the conclusions of this study and practical suggestions were presented.
Effects of secured DNS transport on resolver performance
Authors: Le Louet Etienne , Blin Antoine , Sopena Julien , Haddadou Kamel , Amaou Ahmed
Published: March 2024

Designed 40 years ago, DNS is still a core component of the Internet: billions of DNS queries are processed each day to resolve domain names to IP addresses. Originally designed for performance and scalability, its transport protocol is unencrypted, leading to security flaws. Recently, secure protocols have emerged, but the question of their scalability and sustainability remains open. In this paper, we study the cost of switching from the legacy DNS transport to the newer ones, by first characterising the shape of the traffic between clients and secured public resolvers. Then we replicate said traffic, to measure the added cost of each protocol. We found that, while connections usually stayed open, many closures and openings were made in some cases. Comparing these profiles over different DNS transports, we observe that switching from the legacy protocol to a more secure one can lead to an important performance penalty.
Effects of changes in use and soil cover on real evapotranspiration from the creation of a remote sensing product in the Xingu basin
Authors: Antunes Sarah Christina Ribeiro , Ribeiro Celso Bandeira de Melo , Lima Ricardo Neves de Souza , Getirana Augusto
Published: March 2024

Several studies have shown that changes in land cover within a given watershed significantly affect the hydrological cycle and its variables. In the Xingu basin, many areas had their vegetation replaced by agricultural crops and pastures, while deforestation has been particularly prevalent in the region known as the Arch of Deforestation. Using remote sensing techniques enable the estimation of biophysical variable ETr for extensive areas, as exemplified in the study basin. Evapotranspiration data used in this work were obtained by creating a product that returns the combined median of the MOD16A2, PML_V2, Terra Climate, GLEAM_v3.3a, FLUXCOM, SSEBop, FLDAS, and ERA5-Land models, with subsequent application of the data provided by Collection 6 of the MapBiomas network, allowing the integration of land use and land cover information with real evapotranspiration estimates for the transition ranges: Forest to Pasture; Forest to Agricultural Land; Cerrado to Pasture; Cerrado to Agricultural Land. The interval defined for the study corresponds to the years 1985 to 2020, according to the historical series available on MapBiomas. After applying programming languages to filter the data, the results underwent statistical analysis to elucidate the effects of soil changes on evapotranspiration. Over the total data period (1985-2020), there was a decrease in forest areas (-16.23%), with conversion to pasture areas, in the order of +12.51%, and agricultural areas, reaching +5.5%. In the same timeframe, evapotranspiration in conversion bands underwent minimal changes, notably from 2009 to 2020, where a decreasing trend was reported of 0.095 mm/month for the “forest to pasture” substitution, and 0.090 mm/month in “Cerrado for pasture".
Effect of topical nitroglycerin application on flap survival and complications post reconstructive microsurgery: A systematic review and meta-analysis study of the literature
Authors: Altam Abdulfattah , Al-siaghi Yahya , Alsaaidi Ahmed , Ahmed Faisal , Alhajami Faris , Al-kubati Waheeb , Al-shujaa Mohammed , Alselwi Osama , Badheeb Mohamed , Al-Naggar Abdullah , Othman Basheer
Published: March 2024

Background and Aims: Several methods have been used in plastic and reconstructive surgery to reduce post-surgical complications, such as partial or complete flap loss due to ischemia and necrosis. Nitroglycerine application has been introduced as a viable alternative to papaverine to act as a local vasodilator to improve perfusion and reduce vasospasm. However, the literature has not thoroughly studied its efficacy and administration dose. This systematic review and meta-analysis study has been designed to assess the efficacy of topical nitroglycerine applications in reducing post-surgical flap necrosis and complications.

Methods and Materials: A systematic literature search was performed on PubMed, Scopus, and Web of Science from inception to January 2023 with relevant keywords and terms. Case reports, review articles, letters, articles in any language other than English, and animal studies were excluded. The Newcastle-Ottawa and Jadad scales were used to assess the quality of the included studies. The pooled effect sizes were calculated using the random effect model with the Mantel-Haenszel method.

Results: Overall, 2031 studies were obtained, among which 454 articles were duplicated and removed. Of the remaining 1577 articles, based on the eligibility and exclusion criteria, 20 articles were retrieved for full-text review. Finally, eight articles were included in our study. Three thousand nine hundred six patients had undergone reconstructive microsurgery and received topical nitroglycerin for the prevention of possible complications. The pooled rate of flap complication was 15% (95% CI: 8% to 25%, I2 = 96%, p-value < 0.01), and the pooled odds ratio of flap complication was 0.35 (95% CI: 0.15 to 0.83, I2 = 91%, p-value = 0.02). The heterogeneity of the included studies was significantly high. The dose and regimen of application significantly differed between each study.

Conclusion: Topical administration of nitroglycerin compounds post reconstructive microsurgery can reduce the risk of flap necrosis. However, the precise dosage, duration of application, and possible underlying factors affecting drug efficacy are yet to be discovered.
Enterococcus Cecorum bacteremia and meningitis in an asplenic patient: A case report
Authors: Abdelwahed Hesham , Elkhawaga Mostafa , Oon Aileen
Published: March 2024

This paper presents a case of Enterococcus cecorum (E. cecorum) meningitis with bacteremia in a middle-aged woman who had previously undergone a splenectomy. Within 24 hours, the bacterium was identified from a blood culture. The patient was clinically diagnosed with meningitis, which was radiologically verified by an MRI brain scan. Fortunately, she had a favorable outcome. To the best of our knowledge, this is the first reported case of E. cecorum-induced meningitis in humans and the second documented incidence of E. cecorum infection in humans in Australia. The purpose of this case report is to emphasize the potential for serious human infections caused by an extremely rare pathogen.
La preghiera nella prima esperienza cristiana di Sant’Agostino
Authors: Petrisor Vasile
Published: March 2024

The present article is meant to analyze and value the first Christian experience of Saint Augustine, the one that the bishop of Hippona lived in the bosom of his family and in the midst of community of Tagaste. It will be amazing and surprising to find out, according to Augustine’s testimony, how profound were the foundations of the Christian faith planted in his soul by his mother, Saint Monica. Even the so-called «conversion», sealed with the baptism received in Milan, it’s nothing but a return to the Church and the faith from childhood. It came as a consequence of a long road of retrieval after Augustin has overcome many prejudgments and difficulties of an intellectual and moral nature.
Uspješno starenje: Teorijske koncepcije, odrednice i intervencije
Authors: Delibašić Kerima , Tuce Đenita
Published: March 2024

Over the past few decades, the concept of successful aging has become an increasingly relevant topic in various scientific disciplines, including medicine, biology, psychology, sociology, gerontology, and andragogy. On of the main reasons for this is the continuous extension of the average lifespan, resulting in a higher proportion of older individuals in the general population. Consequently, there is a growing need for understand the challenges faced by this age group and to identify factors contributing to successful aging and the preservation of quality of life in old age. While there is still no unanimously adopted definition of successful aging, what is certain is that successful aging is much more than the absence if disease. It represents a holistic concept encopmpassing the physical, mental, emotional, and social well-being of older individuals, resulting from the complex interplay of personal and environmental factors. Therefore, the study of successful aging requires a multdisciplinary approach to gain a deeper understanding of the complexity of this phenomenon, and to develop strategies that support older individuals in living fulfilling and healthy lives. The aim of this paper is to provide theoretically grounded and empirically supported information about successful aging, its determinants, and interventions aimed at improving the quality of life in old age. Furthermore, this work aims to raise awareness of the importance of this topic and stimulate further interest in it, both among proffesionals and the general public.
Subjective Well-being of Female Nursing Home Residents and Elderly Widowed Females Living with Families: Perspective from Bosnia and Herzegovina
Authors: Mustoo Başer Lejla
Published: March 2024

Subjective well-being (SWB) with its challenges may have different meanings in different developmental milestones. Especially in late adulthood, perspectives of how the elderly perceive old age, either in positive attributes or unfavourable ways, may be significant precursors of experineced satisfaction and happines. The main purpose of this research was to qualitatively explore the SWB among female nursing home residents and elderly females living with their families (N = 12). Results have shown a difference between those who care institutions from those who live with families. Womwn who are nursing home residents reported perceived lower life sense.
Prevalencija anksioznosti, depresivnosti i stresa kod studenata i razlike u razini simptoma s obzirom na spol i dob
Authors: Husić Indira , Dautbegović Amela
Published: March 2024

The aim of the research was to examine the prevalence of unpleasant emotional states among students. An online survey was conducted in the month of April, 2023, and the participants were students of public universities in Bosnia and Herzegovina (N=170). Among the measuring instruments used was the DASS-21questionnaire (The Depression, Anxiety and Stress Scale-21, Lovibond and Lovibond 1995) and a sociodemographic questionnaire, constructed for the purposes of this research. It is expected that students will experience unpleasant emotional states such as anxiety, depression and stress, and that there will be certain differences in the manifestation of symptoms with regard to gender and age. The obtained findings showed that 34.3% of the subjects are in the category of moderate, severe and extremely severe depressive symptoms, then 49,9% of the subjects feel moderate, severe or extremly severe anxiety, while 38.2% of the subjects show moderate, severe and extremly severe symptoms of stress. As for gender and age differences, the results show that female students are more susceptible to the prevalence of unpleasant emotional states, while the hypotesis related to age differences was not confirmed. Namely, the findings indicate that there are no age differences in the manifestation of unpleasant emotional states. Considering the obtained findings, we believe that it is necessary to raise awareness about the significant growing problems of mental health among students and to highlight the need for preventive and intervention programs at universities.
Komparativna analiza sistema obrazovanja odraslih u Bosni i Hercegovini i zemljama jugoistočne Evrope
Authors: Škorić Emina
Published: March 2024

Adult education is now recognized as an integral part of the educational system. Considering its importance and relatively weak interest of authorities in Bosnia and Herzegovina in improving this area, we decided to conduct this research that compares the adventages and disadventages of solutions in Southeast European countries that were part of the former Yugoslavia (Montenegro, Croatia, Nort Macedonia, Slovenia, Serbia). The article presents that state of legislation, institutional competencies, funding models, and the status of the adult education profession. The ultimate purpose of this paper is to describe the complexity of the education system within Bosnia and Herzegovina and identify succesful solutions developed in neighboring countries. The primary method used is the comparative one, comparing the system of Bosnia and Herzegovina with that of the regional countries. The content analysis technique was employed to extract necessary data from relevant documents. The article concludes with recommendations for improving the adult education system in Bosna and Herzegovina.
PENGARUH FORMULASI SANTAN DAN LABU KUNING (Cucurbita moschata) TERHADAP SIFAT FISIK DAN KIMIA ES KRIM
Authors: Selvie Mahrita  , Evi Faridawaty  , Christian Feri
Published: March 2024

Penelitian ini bertujuan untuk mencari pengaruh formulasi dari santan dan labu kuning terhadap sifat fisik dan kimia es krim agar mendapatkan formulasi terbaik. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari satu faktor, yaitu campuran formulasi antara santan dan labu kuning. Penelitian ini menggunakan 4 perlakuan formulasi, yaitu : A0 (50% santan dan 50% labu kuning), A1 (40% santan dan 60% labu kuning), A2 (30% santan dan 70% labu kuning) dan A3 (20% santan dan 80% labu kuning). Pada penelitian ini terdapat 4 perlakuan dan 5 kali ulangan, sehingga terdapat 20 sampel satuan percobaan. Parameter yang di uji meliputi daya leleh (menit), kadar protein (%), kadar air (%), kadar lemak (%), total padatan (%) dan uji organoleptik. Berdasarkan hasil penelitian, formulasi santan dan labu kuning berpengaruh nyata terhadap daya leleh (menit), kadar protein (%), kadar air (%), kadar lemak (%),   total padatan (%) dan uji organoleptik berdasarkan parameter warna dan tekstur, tetapi tidak berpengaruh nyata terhadap rasa dan aroma. Perlakuan A0 (50% santan dan 50% labu kuning) adalah pelakuan terbaik, karena kadar lemak, kadar air dan total padatan memenuhi Standar Nasional Indonesia (SNI) produk es krim
The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine
Authors: Ke Zhipeng , Liu Minxuan , Liu Jing , Su Zhenzhen , Li Lu , Qian Mengyu , Zhang Xinzhuang , Cao Liang , Wang Tuanjie , Wang Zhenzhong , Xiao Wei
Published: March 2024

Review
The Application of Artificial Intelligence in the Research and Development of Traditional Chinese Medicine

Zhipeng Ke 1,2, Minxuan Liu 1,2,3, Jing Liu 1,2, Zhenzhen Su 1,2, Lu Li 1,2, Mengyu Qian 1,2, Xinzhuang Zhang 1,2, Tuanjie Wang 1,2, Liang Cao 1,2, Zhenzhong Wang 1,2, and Wei Xiao 1,2, *

1 National Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture, Lianyungang 222106, China
2 Jiangsu Kanion Pharmaceutical Co., Ltd, Lianyungang 222104, China
3 ‍School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210009, China
* Correspondence: xw_kanion@163.com
 
 
Received: 4 September 2023
Accepted: 4 November 2023
Published: 6 March 2024
 

Abstract: With the accumulation of data in the pharmaceutical industry and the development of artificial intelligence technology, various artificial intelligence methods have been successfully employed in the drug discovery process. The integration of artificial intelligence in Traditional Chinese medicine has also gained momentum, encompassing quality control of Chinese patent medicines, prescriptions optimization, discovery of effective substances, and prediction of side effects. However, artificial intelligence also faces challenges and limitations in Traditional Chinese medicine development, such as data scarcity and complexity, lack of interdisciplinary professionals, black-box models, etc. Therefore, more research and collaboration are needed to address these issues and explore the best ways to integrate artificial intelligence and Traditional Chinese medicine to improve human health.
Mkk7 Protects Against Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction
Authors: Azam Tayyiba , Zhang Hongyuan , Hille Susanne , Müller Oliver J. , Cartwright Elizabeth J. , Wang Xin
Published: March 2024

Article
Mkk7 Protects Against Cardiac Dysfunction in Heart Failure with Preserved Ejection Fraction

Tayyiba Azam 1, * , Hongyuan Zhang 1, Susanne S. Hille 2, Elizabeth J. Cartwright 1, Oliver J. Müller 2, and Xin Wang 1, *

1 Faculty of Biology, Medicine, and Health, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
2 Department of Internal Medicine III, University of Kiel, Germany; German Centre for Cardiovascular Research (DZHK), 24105 Partner Site Hamburg/Kiel/Lübeck, Germany
* Correspondence: xin.wang@manchester.ac.uk (Xin Wang); tayyiba.azam@manchester.ac.uk (Tayyiba Azam)
 
 
Received: 12 June 2023
Accepted: 25 September 2023
Published: 6 March 2024
 

Abstract: Shifts in epidemiological patterns foretell a rapid increase in the number of patients with heart failure (HF) globally, representing a significant health and economic burden. Heart failure with preserved ejection (HFpEF) is now considered the prevailing subtype of HF, with no effective treatment available to combat this syndrome. Previous studies have highlighted the cardioprotective role of MKK7 during cardiac pathology, however, no extensive research has been performed to examine MKK7 in the context of HFpEF. This study aimed to address this shortcoming by using adeno-associated virus (AAV) 9 to overexpress MKK7 in the two-hit clinically relevant HFpEF mouse model. We report that cardiomyocyte-specific overexpression of MKK7 improved the HFpEF phenotype in mice, by impeding cardiac diastolic dysfunction and myocardial fibrosis. Mechanistically, it was found that MKK7 ameliorated ER stress by maintaining IRE1-XBP1 signalling and blunted CHOP increase in the myocardium. To summarise, MKK7 overexpression holds the ability to protect the myocardium from HFpEF associated pathologies.
The Influence of Principal Leadership and Work Discipline on Teacher Performance at SD Negeri 2 Angsau
Authors: Sulasih  , Sunoto Hadi
Published: March 2024

This research aims to: 1) Identify whether the school principal's leadership influences teachers' performance or not; 2) Determine whether teachers' work discipline has an impact on their performance or not; 3) Investigate whether the school principal's leadership and teachers' work discipline together influence teachers' performance. The research subject is SDN 2 Angsau Pelaihari. This research employs a quantitative method with a total of 34 respondents.. The results indicate that: 1) There is a very significant positive influence between the school principal's leadership style and teachers' performance; 2) There is a very significant positive influence between job satisfaction and teachers' performance; 3) There is a positive influence between organizational commitment and job satisfaction together on teachers' performance on 81.8%.
The effect of Omega-3 fatty acid fish oil and seed oilon the prevention of Alzheimers disease
Authors: Li Huaqing , Pan Yueran
Published: March 2024

Omega-3 polyunsaturated fatty acids (n-3 PUFA) are known to reduce cognitive degeneration and potentially prevent Alzheimers disease (AD). Unfortunately, while preventive measures like dietary therapy exist, there are few approved clinical healing therapies for AD. This study aims to investigate the effects of seed oil and fish oil separately in preventing Alzheimers disease. We conducted a systematic literature search to find experimental trials based on animal models and human observational studies examining the relationship between Alzheimers disease and oil supplements rich in n-3 PUFA. The study uses meta-analysis, t-tests, and regression analysis to determine the significance of each type of oil in regulating Alzheimers diseases development. The results suggest that seed oil may help prevent AD by slowing cognitive deterioration, whereas fish oil may not. Overall, omega-3 fatty acids may serve as potential dietary supplements for improving memory and preventing Alzheimers disease.
The mechanism and eciency of mRNA-based dendritic cell immunotherapy
Authors: Wang Jiayi
Published: March 2024

In the recent years, the mentions of immunotherapy has become more and more frequent. What emerged along with it are the various types of immunotherapies. This essay includes an introduction to cancer and tumor with the denition, epidemiology, etiology, statistics such as curability regarding types, gender, and race and typical treatments of cancer along with how the immune system functions when targeting tumor cells and how they could potentially disfunction when deceived by tumor cells for example through immune editing. Then, leading on to the main topic to this recent and innovative treatment immunotherapy. This essay emphasizes on two different types of immunotherapy which are dendritic cell therapy, and messenger RNA vaccine discussing their mechanism as separate treatments. Afterwards, Ill proceed to discuss the combination of the two which is known as dendritic cell based mRNA vaccine which is a form of mRNA vaccine and its own mechanism, advantages, eciency and current limitations in the conclusion.
The relationship between exercise and the immune system
Authors: Wang Huihan
Published: March 2024

Many studies have proved that exercise can improve the human immune system, so that people can better resist diseases, and people who exercise for a long time do have a great advantage in disease resistance and recovery than ordinary people. But how this happens, middle school biology teaches students how the immune system works, how it helps us to destroy our enemies. This is inseparable from the cells in the human body and the substances secreted by the cells. The improvement of the human immune system from exercise certainly does not happen in a vacuum. The human body undergoes great changes during exercise, and these changes must also have an impact on the human immune system. What changes occur in the human body during exercise? Does improving your immune system after exercise work the same way you build muscle and strength after exercise? In order to understand how exercise improves the immune system, the changes of cells and substances closely related to the immune system in the human body after exercise were searched and collected. These cells or substances are important components of the immune system and play a decisive role in a persons immune system, and their changes often directly reflect the strength of the human immune system.
The influence of COVID-19 on the health sector
Authors: Li Junxi
Published: March 2024

Healthcare, as a fundamental component of human well-being, plays a pivotal role in shaping overall quality of life. This research investigates the extensive ramifications of the COVID-19 epidemic on the healthcare sector, encompassing the challenges and opportunities that have emerged in its wake. This study investigates the implications for hospital infrastructure through a comprehensive analysis of pertinent literature. The findings reveal significant deficiencies in essential resources such as ventilators and personal protective equipment (PPE). The evident manifestation of the psychological burden experienced by healthcare personnel highlights the imperative of allocating additional resources to support them. The advent of the pandemic has given rise to telemedicine and other digital alternatives, leading to a significant transformation in the field of healthcare delivery. Lockdowns, mask mandates, and other public health interventions are crucial in mitigating the transmission of the pathogen. Despite facing significant challenges, the ongoing pandemic has accelerated advancements in the field of medicine. This study contributes to the existing body of knowledge regarding effective strategies for addressing future pandemics and underscores the imperative of establishing a healthcare system that is adaptable and responsive. In the era following the COVID-19 pandemic, it is imperative to proactively tackle challenges and explore untapped opportunities in the healthcare sector by continuous research and assertive endeavors.
Directions for the improvement of dendritic vaccines for HER2-positive breast cancer
Authors: Lin Yujie
Published: March 2024

Breast cancer is the disease with the largest number of diagnoses at present, which seriously threatens the health of women all over the world. HER2 positive breast cancer is one of the subtypes, accounting for 25% -30% of breast cancer cases. Despite good progress in chemotherapy, radiation therapy, endocrine therapy and other areas, cancer recovery remains a huge challenge. The development of tumor therapeutic vaccines is a promising strategy. In recent years, more and more vaccines based on different carrier platforms have gradually been discovered. These vaccines stimulate the immune system of patients to produce specific immune responses, thereby reducing the recurrence and metastasis rate of cancer. However, in current clinical research evaluations, no type of vaccine has demonstrated significant therapeutic effects. This paper summarizes the mechanism and types of DC vaccine for HER2 positive breast cancer, analyzes its shortcomings according to relevant clinical trials, and proposes solutions in some aspects such as action target, delivery vector, combined immunity, etc, provides a reference for the development and improvement of therapeutic vaccine for breast cancer in the future. At present, many studies are addressing the problems with some vaccines, and there will be better therapeutic vaccines for breast tumors applied in clinical practice in the future, benefiting all humanity.
The role of protein kinase A signaling in cardiomyopathy
Authors: Yuan Acacia
Published: March 2024

Cardiomyopathy, a diverse group of heart muscle diseases, poses a significant challenge to global cardiovascular health. However, the intricate molecular mechanisms underlying cardiomyopathy, especially the pivotal role of protein kinase A (PKA) signaling pathways in its pathogenesis, remains unclear. The review synthesizes current research findings and highlights the multifaceted interactions between PKA and key cellular components implicated in cardiomyopathy progression. Moreover, this paper unfolds with an exploration of the normal physiological functions of PKA in cardiac cells, emphasizing its role in regulating crucial processes such as excitation-contraction coupling and cellular energy homeostasis. The article navigates through the dysregulation of PKA signaling observed in various forms of cardiomyopathy, including hypertrophic, dilated, and restrictive subtypes. Insightful analyses into the impact of PKA-mediated phosphorylation events on cardiac contractility, ion channel function, and mitochondrial dynamics shed light on the intricate interplay between signaling cascades and disease manifestation. Future clinical trials targeting the PKA signaling pathway are required to seek more effective and precise therapeutic approaches of cardiomyopathy.
Review on the development and research status of hippotherapy in China
Authors: Hu Yutong
Published: March 2024

Hippotherapy, a therapy measure involving horses in the rehabilitation process of people with disabilities, has gained widespread application both domestically and internationally. It involves fields such as medicine and psychology and attracts significant attention. Internationally, hippotherapy has garnered immense interest in the therapy field for people with disabilities and the relevant research has developed rapidly. However, in China, hippotherapy is still in its nascent stage and has not yet established a comprehensive hippotherapy course system. This paper reviews the research progress of hippotherapy in China, explores the therapeutic effect of hippotherapy on children with disabilities, and demonstrates that hippotherapy can effectively aid in the rehabilitation of these children, improving their sports abilities and social communication skills. Therefore, this paper provides a reference for the establishment of a hippotherapy system in China, which can help in improving social acceptance for special children and promoting the overall development of rehabilitation for children with disabilities.
Rumpun Ilmu Agama/Humaniora dalam Perspektif Islam dan Barat
Authors: Sa'idah Niswatus , Anwar Abu
Published: March 2024

Rumpun ilmu agama/humaniora adalah ilmu yang mempelajari dan mengkaji tentang hakikat manusia dengan segala persoalannya yang manusiawi. dari itu sebagai manusia yang beragama mempelajari ilmu agama harus sejalan dengan humaniora. oleh karena itu pembahasan pada jurnal ini yaitu rumpun ilmu agama/humaniora dalam perspektif islam dan barat. tujuan ditulisnya jurnal ini yaitu untuk mengetahui apa saja rumpun ilmu agama serta bagaimana pandangan islam dan barat terhadap ilmu pengetahuan. adapun metode yang digunakan dalam penulisan artikel ini yaitu menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data menggunakan studi kepustakaan atau library research karena data-data yang di perlukan dalam menyelesaikan penelitian tersebut berasal dari buku-buku maupun jurnal ilmiah yang berkaitan dengan judul yang akan dibahas. dari penelitian ini dapat diketahui bahwa dalam Islam tidak ada pemisahan anatar ilmu agama dan umum kerena semuanya bersumber pada Alquran dan Sunnah. Adapun sumber ilmu menurut Islam yaitu wahyu, akal dan pengalaman serta ilham/intuisi. Sebab itulah pada penelitian ini dibahas ilmu agama/humaniora, karena selama ini ilmu humaniora sering dikenal sebagai rumpun ilmu social saja.
Pemanfaatan Media Kartu Bergambar dalam Meningkatkan Kemampuan Literasi Numerasi Anak Usia Dini
Authors: Hulukati Zenab , Yunitasari Septiyani Endang
Published: March 2024

Pengembangan literasi yang dilakukan sejak dini mempunyai dampak besar bagi kehidupan anak di kemudian hari, hal ini berhubungan dengan kesiapan anak untuk mengembangkan pendidikan yang berkualitas sehingga berdampak besar pada anak dalam mencapai pendidikannya. Hasil dari observasi awal yang dilaksanakan oleh peneliti di Sekolah TK Negeri Pembina Timika, menunjukkan bahwa anak cenderung sering tidak berada dalam kondisi alfa. Saat proses pembelajaran berhitung, kondisi di kelas cenderung tidak kondusif dan sulit menerima arahan dari guru. Selain itu, saat peneliti melakukan observasi di sekolah, peneliti melihat pada proses pembelajarannya anak masih kesulitan dalam mengenal angka, menghubungkan angka, kesulitan dalam operasi bilangan. Ditambah lagi, anak kurang tertarik dengan kegiatan mengenal angka dan berhitung. Anak selalu sibuk dengan dirinya sendiri ketika guru menjelaskan. Pada akhirnya, anak juga kurang mau tahu topik apa yang sedang dijelaskan oleh guru. Penelitiann inii memilikii tujuann untukk mengeksplorasi bagaimana perilaku anak serta bagaimana kemampuan literasi numerasi ketika pembelajaran dilakukan menggunakan bantuan media kartu bergambar. Jenis penelitiann yangg digunakann dalam studi ini adalah penelitian mix method dengan pendekatann deskriptif. Berdasarkan hasil penelitian, selain sebagai upaya meningkatkan kemampuan literasi numerasi, penggunaan kartu bergambar membuat proses pembelajaran menjadi menyenangkan, dapat menarik minat anak usia dini sehingga mereka menjadi lebih termotivasi untuk berproses literasi numerasi.
Kepemimpinan Kepala Sekolah dalam Meningkatkan Kinerja Guru Sekolah Dasar X di Kota Medan
Authors: Saragih Eka Fitria , Laili Hasanatun , Vanda Medina Elly , Siregar Mega Rahmadani , Sagala Rizqa Auliyah Shifah , Wasiyem Wasiyem
Published: March 2024

Pendidikan bukan hanya sekedar pengajaran namun juga memberikan ilmu, nilai, dan membentuk kepribadian dari seluruh aspek kehidupan. Ketercapaian tujuan pendidikan sangat tergantung pada kecakapan dan kebijaksanaan kepala sekolah sebagai pemimpin. Penelitian ini bertujuan untuk mengetahui bagaimana kepemimpinan kepala sekolah di sekolah dasar X kemudian Untuk mengetahui bagaimana kinerja guru dalam melaksanakan tugasnya. penelitian ini menggunakan pendekatan kuantitatif deskriptif untuk mengetahui kepemimpinan kepala sekolah dalam meningkatan kinerja guru pada sekolah dasar X di kota Medan dengan metode survey. Teknik pengumpulan data melalui angket/kuesioner dan dokumentasi. Penelitian ini dilakukan terhadap sekolah dasar X di kota Medan dan dilaksanakan pada November-Desember 2023. Populasi penelitian ini adalah seluruh guru Sekolah Dasar X dengan teknik sampling yang digunakan adalah purposive sampling dimana pengambilan sampel dengam pertimbangan tertentu yaitu guru yang bertanggung jawab serta jumlah guru dalam masing-masing kelas menjadi sampel yang berjumlah 6 orang. Berdasarkan hasil penelitian bahwa keterampilan kepemimpinan kepala sekolah dalam meningkatkan kinerja guru sekolah dasar X dilakukan dengan tahapan perencanaan, pelaksanaan, evaluasi dan solusi dalam meningkatkan kinerja guru sekolah dasar.
Rancang Bangun Epistemologi Islam Al-Jabiri dalam Kerangka Keilmuan Pondok Pesantren Miftahul Ulum, Gondanglegi, Malang
Authors: Fahrurrosi Lingga , Husni Muhammad
Published: March 2024

Kerangka keilmuan merupakan tonggak dan tolak ukur ideal dari gambaran sebuah lembaga pendidikan, pun juga pendidikan pesantren. Penelitian ini merupakan kajian mendalam terhadap kerangka keilmuan yang diterapkan di Pondok Pesantren Miftahul Ulum, Gondanglegi, Malang, berlandaskan epistemologi islam yang dicanangkan oleh Abid al-Jabiri. Dengan pendekatan model penelitian kualitatif deskriptif. Pengumpulan data dilakukan menggunakan literatur keilmuan pendukung serta draf kurikulum pesantren yang bersangkutan, maupun melalui wawancara secara langsung. Dari penelitian yang dilakukan, mendapati temuan bahwa rancang bangun kerangka keilmuan di Pondok Pesantren Miftahul Ulum terbilang variatif berdasarkan cakupan dan indikator dari masing-masing dimensinya. Yang paling menonjol dalam hal ini adalah dimensi bayani dan irfani dimana keduanya mendapatkan posisi yang sangat dominan dan strategis dibuktikan melalui banyak sekali rujukan literatur keilmuan yang koheren dengan keduanya. Sedangkan burhani hanya mendapat sedikit sekali porsi implementasi, hal ini pesantren sebagai sebuah wadah transmisi ilmu pengetahuan mengharuskan adanya penataan naskah kurikulum yang lebih terperinci dengan basis epistemik yang tertata secara sistematis di dalamnya.
Stimulasi Aspek Perkembangan Sosial Emosional Anak Tuna Grahita melalui Terapi Aktivitas Kelompok
Authors: Babys Ivone Sole , Yunitasari Septiyani Endang
Published: March 2024

Terapi aktivitas kelompok dipandang dapat meningkatkan interaksi sosial pada anak retardasi mental sehingga peneliti tertarik untuk melakukan penelitian untuk mengetahui stimulasi aspek perkembangan sosial emosional anak Tuna grahita menggunakan terapi aktivitas kelompok di TK Kristen Permata. Penelitian dilakukan selama kurang lebih dua bulan sejak bulan Oktober hingga November 2023 di TK Kristen Permata menggunakan metode penelitian kualitatif deskriptif. Teknik pengumpulan data yang digunakan adalah cek list, observasi, wawancara dan dokumentasi. Subyek penelitian adalah satu orang anak tuna grahita berusia hampir 5 tahun. Informan dalam penelitian adalah orang tua dan guru kelas dari anak tuna grahita di TK Kristen Permata. Terapi aktivitas kelompok yang diberikan kepada anak melalui 3 jenis permainan yakni permainan memasukkan benda ke dalam botol, memasukkan bola ke dalam kotak kardus dan memainkan alat musik terbukti dapat menstimulasi aspek perkembangan sosial emosional anak tuna grahita. Terlihat adanya capaian perkembangan sosial emosional anak yang meliputi perilaku prososial (anak menunjukkan semangat dalam bermain), kesadaran diri (dapat memilih kegiatan sendiri, mematuhi aturan main, memiliki sikap tidak mudah menyerah) dan rasa tanggung jawab terhadap diri sendiri dan orang lain (mampu bekerja sama dengan teman).
Pengaruh Ukuran Perusahaan, Return on Asset dan Debt to Equity Ratio terhadap Nilai Perusahaan yang Dimoderasi oleh Kebijakan Dividen pada Industri Rokok
Authors: Aspari Wahid Yanwar , Ramli Rosmini
Published: March 2024

Tujuan dilakukannya penelitian ini untuk mengetahui pengaruh ukuran perusahaan, return on asset dan debt to equity ratio terhadap nilai perusahaan yang dimoderasi oleh kebijakan dividen pada perusahaan sub sektor rokok yang terdaftar di Bursa Efek Indonesia periode tahun 2012-2022. Teknik pengumpulan sampel menggunakan purposive sampling diperoleh sebanyak 4 perusahaan. Analisis data menggunakan analisis deskriptif asosiatif. Teknik analisis data dalam penelitian ini menggunakan regresi data panel dan moderated regression analysis dengan menggunakan software eviews 12. Berdasarkan hasil dari penelitian ini secara parsial ukuran perusahaan berpengaruh negatif terhadap nilai perusahaan, return on asset berpengaruh positif terhadap nilai perusahaan dan debt to equity ratio tidak berpengaruh terhadap nilai perusahaan. Selanjutnya kebijakan dividen tidak mampu memoderasi hubungan antara ukuran perusahaan terhadap nilai perusahaan, kebijakan dividen mampu memoderasi atau memperlemah hubungan antara return on asset terhadap nilai perusahaan dan kebijakan dividen mampu memoderasi atau memperkuat hubungan antara debt to equity ratio terhadap nilai perusahaan.
Kontribusi Kualitas Kehidupan Kerja terhadap Keterlekatan Karyawan pada Generasi Z
Authors: Nurhalizah Siti Supriyadi , Mulyani Indah
Published: March 2024

Keterlekatan karyawan adalah salah satu kunci keberhasilan untuk mencapai visi dan misi perusahaan secara optimal.  Keterlekatan karyawan menunjang dalam seseorang engaged dalam bekerja, maka karyawan akan senang dan puas terhadap pekerjaan.  Dapat dikatakan bahwa rasa senang dan puas seorang karyawan dapat dilihat bagaimana perusahaan dapat memberikan kualitas kehidupan kerja terhadap karyawannya. Penelitian ini bertujuan untuk melihat kontribusi kualitas kehidupan kerja terhadap keterlekatan karyawan pada generasi Z. Penelitian ini menggunakan pendekatan kuantitatif. Alat ukur yang digunakan yaitu Development and application of a new measure of employee engagement: the ISA Engagement Scale untuk mengukur keterlekatan karyawan. Work-related quality of life (WRQoL) scale untuk mengukur kualitas kehidupan kerja. Pengujian hipotesis dilakukan dengan analisis regresi sederhana. Hasil penelitian menunjukkan terdapat kontribusi kualitas kehidupan kerja terhadap keterlekatan karyawan pada generasi Z. Dimana hal tersebut menunjukkan bahwa semakin tinggi kualitas kehidupan kerja, maka semakin tinggi keterlekatan karyawan pada generasi Z. Penelitian ini dapat menjadi referensi pembuatan modul untuk jurusan psikologi, serta pihak lainnya untuk meningkatkan keterlekatan karyawan dengan memperhatikan kualitas kehidupan kerja.
Tinjauan Ontologi Pekan Gawai Dayak Sebagai Daya Tarik Wisata Budaya di Kota Pontianak
Authors: Djunaid Ika Suryono , Fahlevi Renza , Sinambela Fitriana Aidnilla , Djati Sundring Pantja , Nurbaeti Nurbaeti
Published: March 2024

Pariwisata budaya merupakan salah satu sektor pariwisata yang memiliki potensi besar untuk dikembangkan, karena dapat memberikan kontribusi positif bagi pembangunan sosial, ekonomi, dan lingkungan. Salah satu peristiwa budaya yang menjadi daya tarik wisata budaya di kota Pontianak adalah Pekan Gawai Dayak, yang merupakan perayaan tradisional suku Dayak yang menampilkan berbagai unsur budaya seperti nyangahathn, permainan, kerajinan, dan kerajaan. Penelitian ini bertujuan untuk mengkaji ontologi Pekan Gawai Dayak sebagai daya tarik wisata budaya di kota Pontianak, dengan menggunakan pendekatan kualitatif deskriptif. Data dikumpulkan melalui studi literatur, observasi, dan wawancara dengan narasumber yang terkait dengan Pekan Gawai Dayak. Hasil penelitian menunjukkan bahwa Pekan Gawai Dayak memberikan makna secara sosial, ekonomi, budaya, dan spiritual bagi masyarakat Dayak, serta meningkatkan pengembangan dan pelestarian seni dan budaya Dayak. Pekan Gawai Dayak memiliki potensi yang besar menjadi daya tarik wisata budaya bagi wisatawan lokal maupun mancanegara. Ontologi dapat mendukung pengembangan pariwisata Pekan Gawai Dayak dengan tiga cara, yaitu : (1) mengidentifikasi dan mengklasifikasikan berbagai entitas yang terkait dengan Pekan Gawai Dayak, (2) menggali dan mengungkapkan makna dan nilai budaya yang terkandung dalam Pekan Gawai Dayak, dan (3) mengintegrasikan dan mengkoordinasikan berbagai sumber dan pihak yang terlibat dalam Pekan Gawai Dayak. Penelitian ini memberikan kontribusi teoritis dan praktis bagi pengembangan pariwisata budaya di kota Pontianak, khususnya Pekan Gawai Dayak, serta memberikan saran dan rekomendasi untuk penelitian selanjutnya.
Hubungan Ketebalan Lemak dengan Fleksibilitas Trunkus Remaja Putri
Authors: Lestari Utami Sasmita , Angmalisang Elvin Clara , Jayanti Meilani
Published: March 2024

Remaja merupakan masa transisi dari anak-anak menuju dewasa. Masa remaja dapat menjadi salah satu indikator profil kesehatan pada masa lanjut kelak. Remaja cenderung memiliki gaya hidup sedentary. Penelitian ini bertujuan mengetahui hubungan ketebalan lemak dengan fleksibilitas trunkus pada remaja putri. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain cross sectional. Sampel diperoleh dengan teknik purposive sampling dengan kriteria inklusi yaitu remaja putri berusia 12-17 tahun, tidak menyandang deformitas postur tubuh maupun disabilitas fisik, dan mampu berbahasa Indonesia. Ketebalan lemak diukur dengan menggunakan skinfold calliper. Fingertip-to-floor (FTF) digunakan untuk mengetahui fleksibilitas trunkus remaja putri. Semakin rendah ketebalan lemak maka fleksibilitas trunkus semakin baik. Hasil penelitian menunjukkan mayoritas subjek penelitian memiliki tingkat ketebalan lemak dan fleksibilitas trunkus kategori normal. Uji hubungan antara ketebalan lemak dengan fleksibilitas trunkus dengan p=0,028 menunjukkan adanya hubungan yang bermakna antara ketebalan lemak dengan fleksibilitas trunkus remaja putri.
Peran Kiai dalam Pembinaan Akhlak Santri di Pondok Pesantren Pagelaran III
Authors: Ruhdiyanto Didit , Sohim Badru , Afif Shaleh , Ardilah Novi , Ubaydillah Syeha Bagja
Published: March 2024

Kiai sebagai sosok kharismatik memiliki pengaruh dan peran yang sangat besar dalam pembinaan akhlak santri, selain sebagai figur sentral, kiai melalui keilmuannya yang mendalam juga dapat menentukan sistem pendidikan di pesantren. Keilmuan seorang kiai biasanya memiliki sanad yang sangat kuat dan terjaga kepada pemilik utamanya. data yang digunakan adalah sumber data primer dan sumber data sekunder dengan teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Sedangkan analisis data dilakukan melalui proses reduksi data, penyajian data dan verifikasi data. Hasil penelitian menunjukkan bahwa kiai memegang peranan penting dalam menentukan pola pada sistem pendidikan pondok pesantren, sehingga tidak sedikit pesantren meski sudah modern pada sistem pendidikannya tetap mempertimbangkan kebijakan dari seorang kiai pesantren tersebut. Aktualitas akhlak santri bisa dikategorikan baik dengan memiliki cakupan yang biasa disebut nilai-nilai pendidikan akhlak.