bluuebunny/crossref_metadata_2025 huggingface dataset:
Kako komunicirati s korisnicima
Authors: Krpan Kristina , Bunić Sanja
Published: July 2024

Cilj. Cilj je rada ukazati na važnost sudjelovanja knjižničarskih tehničara u kontinuiranom neformalnom obrazovanju knjižničara u području komunikacijskih vještina.

Pristup. U prvom dijelu rada razmatraju se teorijske postavke obrazovanja knjižničara u području komunikacijskih vještina te njihov utjecaj na organizacijsku kulturu. Posebna pozornost posvećena je specifičnostima komunikacije u informacijskoj službi u narodnim knjižnicama i unutar mreže narodnih knjižnica. Ukazuje se i na potrebu edukacije iz područja upravljanja emocijama. U drugom dijelu rada prikazano je kako su organizirane edukacije u kojima su ciljano sudjelovali knjižničarski tehničari Knjižnica grada Zagreba – dva ciklusa radionica komunikacijskih vještina na temu konfliktnih i kriznih situacija, nošenja sa stresom te jednokratna edukacija o asertivnoj komunikaciji i aplikaciji eZaKi. U zadnjem dijelu rada na temelju teorijskih postavki i iskustava iz prakse dane su preporuke za organizaciju kontinuiranog neformalnog obrazovanja knjižničara u području komunikacijskih vještina.

Rezultati. Rezultati evaluacije pokazali su visoku razinu zadovoljstva sudionika organizacijom i provedbom edukacija, dragocjenost razmjene iskustva i učenja tijekom radionica, jačanje zajedništva i osvještavanje organizacijske kulture, kao i potrebu za kontinuitetom u provedbi sličnih radionica.

Praktična primjena. Opis načina organizacije, provedbe i evaluacije radionica komunikacijskih vještina može poslužiti kao primjer dobre prakse neformalne edukacije knjižničarskog osoblja te poticaj drugim knjižnicama na organizaciju sličnih radionica.

Originalnost. U radu je prvi puta u stručnoj knjižničarskoj literaturi u Hrvatskoj prikazan primjer prakse stručnog usavršavanja knjižničarskih tehničara iz područja komunikacijskih vještina. Ukazano je i na potrebu za edukacijom iz područja upravljanja emocijama tijekom rada u informacijskoj službi.
Получение и сравнительная оценка лечебных свойств мазей на основе меланинов из гриба Inonotus obliquus
Authors: Ставский Е. , Теплякова Т. , Надеев А. , Ставская А. , Жайворон А. , Ермаченко М. , Зарубина Ю. , Осадчая А. , Яшина Т.
Published: July 2024

Показана равнозначность in vivo по биологическим и лечебным свойствам между меланинами, полученными из природного сырья и глубинной культуры гриба чаги Inonotus obliquus методом щелочного гидролиза, а также мазей на их основе. Ранозаживляющую эффективность мазей оценивали на 5 группах (по 20 мышей в каждой) здоровых неинбредных мышах с массой тела 17 – 19 г колонии ICR обоего пола. Контрольной являлась группа мышей, леченных мазью сравнения Левомикон-ТФФ. Лечение мышей продолжали до момента заживления у них резаных кожных ран. Ежедневно во всех группах оценивали двигательную активность, аппетит, динамику заживления ран, через каждые 3 суток — изменение массы тела. Гистоморфологически изучали резаную рану, кожи, определяли площадь ран и процент ее уменьшения, скорости контракции и заживления ран. Компоненты мазевых основ испытанных мазей, меланины чаги обоих видов в диапазоне 0,05 – 0,25 г на 25 г, не обладают токсичностью для экспериментальных животных, но имеют одинаковые регенеративные свойства. При этом мази с пятикратно увеличенным содержанием в них меланинов (по 0,25 г на 25 г мази) обеспечивали существенно ускоренное заживление ран. В этом случае развитие в ране грануляционной ткани и замещение раневого дефекта в коже многослойным плоским эпителием было достигнуто уже на 12-е сутки. У мышей контрольной группы, а также у мышей, леченных мазями с содержанием меланинов по 0,05 г на 25 г мази, дефект эпидермиса был устранен только на 21-е сутки.
Вариабельность состава амино- и органических кислот цветков каштана конского обыкновенного
Authors: Дунилин А. , Тринеева О.
Published: July 2024

Проведен сравнительный анализ методом капиллярного электрофореза аминокислотного состава и профиля органических кислот в цветках каштана конского из 5 регионов произрастания. В цветках каштана содержится разнотипная группа органических и аминокислот, но отсутствует прослеживаемая зависимость к накоплению тождественных соединений среди цветков, заготовленных в разных регионах. Профиль органических кислот также неоднороден, однако в цветках из Ленинградской и Московской областях, Ставропольского края в сумме органических кислот превалировала пропионовая кислота — 2,64; 2,18 и 2,31 % соответственно. Полученные результаты могут служить одним из критериев качества сырья, а также дополнят имеющиеся в литературе данные по фитохимическому составу различных групп БАВ в цветках растения и его вариабельности в зависимости от совокупности эколого-географических условий произрастания.
Supporting Distributed Learning through Immersive Learning Environments
Authors: Lecon Carsten
Published: July 2024

In this paper, we describe a teaching scenario using a virtual environment (known also in the context of the ‘metaverse’). This is motivated by the challenges that arise during the pandemic. More and more teaching scenarios are transferred to online learning settings, which allow learning at any time and at any time. One of the possibilities are virtual 3D environment. These allow more intensive immersion than for example video conferences. Furthermore, they offer new didactic concepts, for example, for group activities. The benefit of using virtual 3D environments we demonstrate by a concrete learning scenario: the simulation of robot programming. A further advantage when using virtual 3D environments are personal assistants (conversational/ pedagogical agents), for example, to the ease the work load borne by teachers; meanwhile, this works well also with natural language due to advantage stage of artificial intelligence implementations. Keywords: e-learning, e-teaching, immersion, virtual 3D rooms, gamification, cyber-physical systems
Perencanaan Tata Letak Gudang dengan Prinsip 5S (Seiri, Seiso, Seiton, Seiketsu, dan Shitsuke) Pada PT. Aneka Coffee Industry Guna Meminimalkan Waktu Pencarian di Gudang
Authors: Setiana Aldiansyah Fiqri , Murnawan Hery
Published: July 2024

PT. Aneka Coffee Industry is an industrial company in Indonesia engaged in the production of coffee, both in the form of beans and processed coffee products. This research aims to plan warehouse layout using the 5S principles (Seiri, Seiso, Seiton, Seiketsu, and Shitsuke) at PT. Aneka Coffee Industry with the goal of minimizing search time in the warehouse. The method used in this research includes collecting primary and secondary data related to storage and retrieval processes in the warehouse and applying the 5S principles. Analysis was conducted to evaluate the effectiveness of the 5S principles in reducing search time in the warehouse. The results of the research indicate that the application of the 5S principles can improve warehouse layout efficiency and significantly reduce search time. The implication of this research is the importance of implementing the 5S principles in warehouse layout planning to enhance company productivity and operational efficiency. In conclusion, integrating the 5S principles becomes one of the effective strategies in enhancing warehouse performance and reducing search time for items.
Desain Proses Produksi dalam Proyek Pembuatan Mesin Pencacah Kompos pada Kegiatan di PT Raja Ampat Indotim
Authors: Surya Raygalan Kalmas , Maksum Apid Hapid
Published: July 2024

The performance of the industrial system in producing goods will be very important for business continuity, such as meeting consumer demand so that it can maintain the sustainability and/or continuity of the company in order to survive. Currently, companies will always be required to maintain and improve their competitive capabilities, so one way to do this is by increasing productivity at all levels within the company. The author tries to identify the work process of PT. Raja Ampat Indotim in the production of Compost Chopper Machines due to the results of interviews conducted at the company, there were no procedures for the work process in producing Compost Chopper Machines, so on this occasion the author intends to design a standard work process in the production of compost chopper machines at PT. Raja Ampat Indotim. Data processing in this research was carried out using an Operation Process Map. Based on the operational process map that has been created, the time required to produce a Compost Shredding Machine is 968.29 minutes.
Prenatal Ultrasound in Fetal Inferior Vena Cava Abnormalities: Image Characteristics and Clinical Relevance
Authors: Yan Huaying , Zhang Chunguo , Kang Yu , He Lihong
Published: July 2024

Background: During the embryonic stage, the inferior vena cava (IVC) is an important conduit for the hepatic vein and ductus venosus to drain into the right atrium. For fetuses with IVC abnormalities, the prognosis may be favorable if the condition is not complicated with other malformations, but would be poor if atrial isomerism coexists. In severe cases, edema, intrauterine fetal death, and atrioventricular block may occur. Therefore, comprehensive prenatal ultrasound that provides detailed information about IVC abnormalities may be clinically significant. Methods: A total of 180 fetuses diagnosed with IVC anomalies via prenatal ultrasound at Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Provincial Maternity and Child Health Care Hospital from January, 2017 to December, 2022 were included in this study. Their ultrasound image characteristics, associated intra- or extracardiac malformations and pregnancy outcomes were retrospectively analyzed. Results: Among the 180 fetuses, 59 cases were diagnosed with interrupted IVC (53 cases with the interruption of the hepatic segment of the right IVC and 6 cases with the interruption of the entire right IVC), 1 case was diagnosed with the stenosis of the hepatic segment of the right IVC, 90 cases were diagnosed with left sided IVC, 29 cases with double IVC, and 1 case with abnormal connection of the IVC to the left atrium. Moreover, 33 cases had intracardiac malformations and 36 cases had extracardiac malformations. Pregnancy outcomes: 160 fetuses were live born, and their prenatal ultrasound diagnoses were confirmed by computed tomography (CT)/magnetic resonance imaging (MRI) or surgery; the remaining 20 fetuses were terminated due to serious malformations, and their prenatal ultrasound diagnoses were confirmed by pathologic examination. Conclusions: Prenatal ultrasound can clearly reveal the fetal IVC abnormalities and the associated intra- or extracardiac malformations. For suspected cases, attention should be focused on prenatal ultrasound examinations in order to obtain valuable information for prenatal consultation and subsequent procedures and care.
Effect of Application of Dexmedetomidine in Perioperative Period on Postoperative Pain, Stress in Patients Undergoing Laparoscopic Uterine Fibroids Surgery: A Randomized Controlled Study
Authors: Cao Xia , Ding Xu , Sun Huihui , Zhang Lihong , Li Xiang
Published: July 2024

Background: This study aimed to evaluate whether dexmedetomidine (DEX) can relieve postoperative pain and reduce stress reaction after laparoscopic uterine fibroids (UF) surgery. Methods: This randomized controlled study included 100 patients age range of 40–60 years, American Society of Anesthesiologists (ASA) 1–2 grade, admitted for laparoscopic UF surgery from January 2020 to October 2023. The patients were randomly allocated to the DEX group (n = 50) and non-DEX group (n = 50). The visual analogue scale (VAS), Richmond Agitation-Sedation Scale (RASS) score, anesthesia time, spontaneous breathing recovery time, consciousness recovery time, extubation time, and recovery room time were recorded. Results: The VAS of the DEX group was smaller than that of the non-DEX group at half an hour, but there was no significant difference in VAS at 1 h, 12 h and 24 h. Dex group has a RASS value closer to zero than non-DEX group at half an hour. There was no significant difference in RASS at 1 h, 12 h, or 24 h. There were differences in spontaneous breathing recovery time, consciousness recovery time, extubation time, recovery room time, chills and nausea between the two groups. Conclusion: Application of DEX in perioperative period can relieve postoperative pain, reduce stress reaction after laparoscopic UF surgery. Clinical Trial Registration: The study has been registered on https://classic.clinicaltrials.gov/ (registration number: NCT03524950).
The Glucose-Glutamine Metabolic Interplay in MCF-7 Cells, a Hormone-Sensitive Breast Cancer Model
Authors: Carta Sonia , Ghelardoni Maddalena , Vitale Francesca , Ravera Silvia , Cossu Vanessa , Bertola Nadia , Losacco Serena , Martinelli Jonathan , Dighero Edoardo , Riondato Mattia , Orengo Anna Maria , Bauckneht Matteo , Chiesa Sabrina , Sambuceti Gianmario , Marini Cecilia
Published: July 2024

Background: Selective deprivation of glutamine has been shown to accelerate the generation of reactive oxygen species (ROS) and to impair the activity of a specific pentose phosphate pathway (PPP) located within the endoplasmic reticulum (ER). The consequent oxidative damage suggests that glucose flux through this reticular pathway might contribute to the redox stress of breast cancer cells. We thus evaluated whether this response is reproduced when the glutamine shortage is coupled with the glucose deprivation. Methods: Cancer growth, metabolic plasticity and redox status were evaluated under saturating conditions and after 48 h starvation (glucose 2.5 mM, glutamine 0.5 mM). The Seahorse technology was used to estimate adenosine triphosphate (ATP)-linked and ATP-independent oxygen consumption rate (OCR) as well as proton efflux rate (PER). 18F-fluoro-deoxy-glucose (FDG) uptake was evaluated through the LigandTracer device. Proliferation rate was estimated by the carboxyfluorescein-diacetate-succinimidyl ester (CFSE) staining, while cell viability by the propidium iodide exclusion assay. Results: Starvation reduced the proliferation rate of MCF-7 cells without affecting their viability. It also decreased lactate release and PER. Overall OCR was left unchanged although ATP-synthase dependent fraction was increased under nutrient shortage. Glutaminolysis inhibition selectively impaired the ATP-independent and the oligomycin-sensitive OCR in control and starved cultures, respectively. The combined nutrient shortage decreased the cytosolic and mitochondrial markers of redox stress. It also left unchanged the expression of the reticular unfolded protein marker GRP78. By contrast, starvation decreased the expression of hexose-6P-dehydrogenase (H6PD) thus decreasing the glucose flux through the ER-PPP as documented by the profound impairment in the uptake rate of FDG. Conclusions: When combined with glucose deprivation, glutamine shortage does not elicit the expected enhancement of ROS generation in the studied breast cancer cell line. Combined with the decreased activity of ER-PPP, this observation suggests that glutamine interferes with the reticular glucose metabolism to regulate the cell redox balance.
Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer
Authors: Duy Le Vu , Huong Pham Thi , Nam Nguyen Trung , Trang Do Thi , Chau Nghiem Thi Minh , Thao Tran Thi Phuong , Hoang Nguyen Huy , Tao Nguyen Thien , Mao Can Van , Xuan Nguyen Thi
Published: July 2024

Background: Prostate cancer (PCa) is one of the most common malignant tumors of the male urinary system, and its incidence and mortality rates have been increasing worldwide. Benign prostatic hyperplasia (BPH) represents stromal and epithelial cell proliferation in the prostate in elderly males. Abnormal activation of inflammation-related signalling molecules, such as toll-like receptor 4 (TLR4) and Janus kinase/signal transducers and activators of transcription (JAK/STAT) has been linked to the initiation and progression of various human diseases including PCa and BPH. Cylindromatosis (CYLD) gene alterations are associated with PCa progression. In this study, the contribution of CYLD, JAK2, and TLR4 gene variants to PCa and BPH risks and their associations with prostate-specific antigen (PSA) levels, immunophenotype, and clinical features in Vietnamese men were determined. Methods: A total of 102 patients with PCa, 65 with BPH, and 114 healthy controls were enrolled. The immunophenotype was analyzed by flow cytometry, cytokine secretion by enzyme-linked immunosorbent assay (ELISA), and gene variants by DNA sequencing. Results: Lower levels of transforming growth factor β (TGF-β) and higher numbers of CD13+CD117- and CD56+CD25+ cells were observed in the PCa group than in the BPH group. Genetic analysis of the CYLD gene identified five single nucleotide polymorphisms (SNPs), of which c.2351-47 C>T, c.2351-46A>T, and rs1971432171 T>G had significantly higher frequencies in PCa patients than in the control and BPH groups. Sequencing of the TLR4 gene revealed five nucleotide changes, in which the rs2149356 SNP showed an increased risk for both PCa and BPH and the c.331-206 SNP had a reduced risk for PCa. Importantly, the expansion of activated natural killer (NK) cells and higher levels of PSA were found in PCa patients carrying the CT genotype of the CYLD c.2351-47 compared to those with the wild-type genotype. Conclusion: Activation of NK cells in CYLD-sensitive PCa patients was associated with serum PSA release and the CYLD c.2351-47 variant may be a significant risk factor for prostatitis in PCa patients.
Tumor-Specific Alterations in Motor Cortex Excitability and Tractography of the Corticospinal Tract—A Navigated Transcranial Magnetic Stimulation Study
Authors: Eibl Thomas , Schrey Michael , Liebert Adrian , Ritter Leonard , Lange Rüdiger , Steiner Hans-Herbert , Schebesch Karl-Michael
Published: July 2024

Background: Non-invasive brain mapping using navigated transcranial magnetic stimulation (nTMS) is a valuable tool prior to resection of malignant brain tumors. With nTMS motor mapping, it is additionally possible to analyze the function of the motor system and to evaluate tumor-induced neuroplasticity. Distinct changes in motor cortex excitability induced by certain malignant brain tumors are a focal point of research. Methods: A retrospective single-center study was conducted involving patients with malignant brain tumors. Clinical data, resting motor threshold (rMT), and nTMS-based tractography were evaluated. The interhemispheric rMT-ratio (rMTTumor/rMTControl) was calculated for each extremity and considered pathological if it was >110% or <90%. Distances between the corticospinal tract and the tumor (lesion-to-tract-distance – LTD) were measured. Results: 49 patients were evaluated. 16 patients (32.7%) had a preoperative motor deficit. The cohort comprised 22 glioblastomas (44.9%), 5 gliomas of Classification of Tumors of the Central Nervous System (CNS WHO) grade 3 (10.2%), 6 gliomas of CNS WHO grade 2 (12.2%) and 16 cerebral metastases (32.7%). 26 (53.1%) had a pathological rMT-ratio for the upper extremity and 35 (71.4%) for the lower extremity. All patients with tumor-induced motor deficits had pathological interhemispheric rMT-ratios, and presence of tumor-induced motor deficits was associated with infiltration of the tumor to the nTMS-positive cortex (p = 0.04) and shorter LTDs (all p < 0.021). Pathological interhemispheric rMT-ratio for the upper extremity was associated with cerebral metastases, but not with gliomas (p = 0.002). Conclusions: Our study underlines the diagnostic potential of nTMS motor mapping to go beyond surgical risk stratification. Pathological alterations in motor cortex excitability can be measured with nTMS mapping. Pathological cortical excitability was more frequent in cerebral metastases than in gliomas.
Gender characteristics of students' self-efficacy development
Authors: Drigus Maria ,   G. S. Kostiuk Institute of psychology
Published: July 2024

Introduction. Promotion of psychological well-being and positive mental health of Ukrainians acquires special significance in wartime and post-war recovery. Self-efficacy/personal effectiveness, which contributes to the establishment of an ecologically comfortable personal status in the systems "self-self", "self - activity", "self - others", "self - society", is a factor that helps preserve mental health of the individual. Aim: to analyze the gender characteristics of the development of self-efficacy/personal effectiveness at the initial stage of students' university studies. Methods: a theoretical and methodological analyses of the problem of self-efficacy; a conceptual review of the latest Ukrainian and foreign scientific explorations; analysis (comparative, apperceptive, comparative) of experimental material, as well as the conceptual-experimental approaches to determining the levels of self-efficacy - the Generalized Self-Efficacy Scale (Schwarzer & Jerusalem, 1995). Results. Self-efficacy of students of socionomic professions was analyzed from two perspectives: self-efficacy as a value of a young person at the initial stage of university studies; the gender-specific features of the development of self-efficacy at the initial stage of university studies. Conclusions. Self-efficacy as a determinant of the development of the individual as a "system of systems" (Kostiuk, 1989) and as an internal resource for the stability of positive health acquires special significance in the educational and social space of today. In the modern conditions of crisis, self-efficacy retains the status of a valuable personal determinant. The self-acceptance of the significance of students' personal effectiveness at the initial stage of university studies was highlighted and the gender characteristics of the self-efficacy of students of socionomic professions were established at a statistically significant level. Besides, it was shown that self-efficacy of students of socionomic professions of different genders tended to depend on students' age.
Theoretical analysis of the principles of mental health policy in Ukrainian society
Authors: Dubych Serhii ,   State University of Trade and Economics
Published: July 2024

Introduction. Mental health is a recognized priority both at the societal and personal level. At the same time, the unique challenges faced by the Ukrainian society necessitate a more thorough study of the problem of mental health. Aim: to identify the foundations and basic principles of mental health policy development. Methods: theoretical analysis and systematization. Results. Different aspects of the problem of mental health found in scientific literature were highlighted. The achievements of the scientific and professional community regarding the institutional support for the mental health of the population including the WHO documents and Ukrainian legal acts were analyzed. It was shown that the declared principles of building a system of mental health care have not been implemented in everyday practice. Conclusions. Currently, the creation of mental health care in Ukraine has only been declared, but not implemented on a practical level.
“Kazakhization” and Ethnic Formation of Kazakhs
Authors: Mukhamedina Shamshiya
Published: July 2024

Global challenges at the turn of the XX and XXI centuries still exposed, if not exacerbated, the problem of ethnic mobilization bordering on extremism. This problem is actual for Kazakhstan, too. “Kazakhization” can be accompanied not only by interethnic tension, but also by an ethno-clan struggle for power, which took place in the historical development of the Kazakh people. The author focuses on the analysis of the ethnic formation of the Kazakhs as a conglomerate community that has undergone various forms of identity - from tribal to imperial. The formation of the Kazakh people is a proof to refute “kazakhization”.
About the Place of N.N. Ogloblin in the Development of Russian Historical Siberian Studies of the Late 19th – Early 20th Centuries
Authors: Silaeva Irina
Published: July 2024

The article is devoted to the creative activity of a prominent Russian historian of the turn of the 19th - 20thcenturies, N.N. Ogloblin, who systematized the documents of the extensive fund of the Siberian Order, preparing a four-volume “Review of columns and books”, highly appreciated by both contemporaries and historians of the late 19th - early 21st centuries. In addition to this fundamental work, N.N. Ogloblin, based on the materials of the Siberian Order Foundation, prepared dozens of articles and notes reflecting various aspects of the history of Asian Russia in the late 16th - mid 18th centuries.
Disinformation for Hire? Dispelling Exaggerated Concerns about Social Media Influencers’ Role in Spreading Misinformation
Authors: Klüser Klaus Jonathan , Hoes Emma
Published: July 2024

Amidst rampant concerns about disinformation, social media influencers (SMIs) can capitalize on their often enormous outreach to spread false claims among their followers. However, despite their sizeable potential, the extent to which SMIs sow discord and endorse false narratives is uncharted territory. In this paper, we explore the scale at which SMIs engage with misinformation. We begin by gathering posts from English-speaking influencers with over 500,000 followers on Instagram using CrowdTangle. We then identify instances of disputed content by (i) cross-referencing posts with verified false claims from Politifact, and (ii) manual fact-checking of a random sample of 1000 political posts. This research is pioneering in providing empirical evidence on SMIs' participation in spreading falsehoods. Yet, we find that the concerns are exaggerated, as the involvement of SMIs in propagating false claims is minimal, with only 0.003\% of the more than 1.3 million posts analyzed actually supporting statements flagged as disputed by Politifact.
Pedestrian flow Characteristics and Level of Service Assessment for Footpaths along the section of Koshi Highway, at Biratnagar
Authors: Dahal Sahil
Published: July 2024

Pedestrians are considered to be one of the vulnerable road users in regards to road safety. Biratnagar stands as one of Nepal's bustling cities with several ongoing road development project. Being one of the busiest city, activities of the city should be supported by adequate facilities, such as pedestrian facilities— crucial yet much neglected matters, so pedestrians can walk along the roadway. As a result, conflicts between pedestrians with motor vehicle users and accidents might occur at any time. This study was aimed at investigating the geometric conditions of pedestrian facilities, identifying the characteristics of pedestrians and the pedestrian facilities and determining the level of service for pedestrian facilities at three junctions of Koshi Highway. The study was conducted through survey of location, survey of geometric conditions, estimation of the number of pedestrians using sidewalk (data recorded every 15 minutes), measurement of pedestrian speed, and questionnaire about pedestrian’s identity, destination, as well as travel time and distance. Data analysis was carried out to identify the pedestrian characteristics, pedestrian flow characteristics, and pedestrian level of service. The obtained data were then analyzed using INDO HCM 2017 in order to find out the level of service and it was found the sidewalk at those junctions has PLOS of grade “A” and further the project also included the qualitative assessment for analysis of geometric condition of pedestrian facilities.
A Study on Impact of Electronics Government Procurement on Procurement Effectiveness of the Building Construction Works at Jumla
Authors: Budthapa Birendra Bahadur , Neupane Uttam , Bhattarai Subash Kumar , Sharma Socrates Bhattarai
Published: July 2024

E-procurement is the modern way of using electronic tools, such as the Internet and e- mail for business-to-business purchases online. Besides, it also helps to supply and provide services for sales online using Internet-based technology and can be a tool used by all governments to promote more extensive reforms in the areas of advancing the social, technological, and economic infrastructure. Procurement of construction works, goods and services electronically in addition will increase transparency and accountability, improve standardization and healthy competition, reducing usage of paper and hard copy documentation as well as improving the efficiency, effectiveness of the procurement process. E-Procurement implementation at the building construction work at Jumla district level in some impact i.e., processing time reduce; accessibility increase was bothered by low as compared with cost saving and increasing transparency but all included impact on structural questionnaire is reliable (Reliable test value = 0.987) on procurement of building construction work.
Methods of data analysis used in this research are by using a software program SPSS (Statistical Package for the Social Sciences) to examine the relationship between variables. RII (Relative Importance Index) ranked introduced impact of e-GP on procurement efficiency. The population used in this study are clients, consultants and contractors who are directly involved in procurement of building construction work of Jumla district.
Finally, Nepalese construction industry should focus on adopting electronic procurement on all construction work by facilitating IT & ICT infrastructure to more significantly enhanced the procurement effectiveness construction industry.
Evaluation of Operational Performance of Jawalakhel Roundabout at existing condition and Impact of Geometric Improvement on Its Operational Performance
Authors: Karkee Deepa , Poudel Reshu , Dhungel Subash
Published: July 2024

The study provides an overview of the existing operational performance of Jawalakhel Roundabout with and without cycle lanes in terms of current and future traffic. Jawalakhel is located in the central business district of Lalitpur and connects busy approaches. This connects Pulchowk in the North, Lagankhel in the East, Ekantakuna in the South, and Zoo in the West. It is serving to minimize the resulting conflict between the vehicles; however, due to increasing vehicular movements it is facing challenges like delay, poor level of service and traffic congestion. Video graphic survey method was applied for the collection of traffic volume data and pedestrian volume data during peak hours. The environment and traffic flow parameters are modeled in software 'SIDRA Intersection 8.0'. The calibration and validation of the roundabout model in the software are performed using field data. The performance of the roundabout is assessed based on the LOS, Average Delay, Queue length and is followed by the implementation of the performance enhancement strategies. After analysis, delay; degree of saturation; level of service & 95% of queue vehicles was calculated for existing condition and performance after five years were also analyzed. As a result, the existing performance of the Jawalakhel roundabout was not found to be satisfactory. The result was observed after changing the geometric design of Jawalakhel roundabout.
The Effect of Earnings Per Share and Dividend Per Share on the Market Price Per Share of Listed Commercial Banks on the Nepal Stock Exchange
Authors: Khadka Kamal Kumar , Gaire Laxman Prasad
Published: July 2024

This study targeted to evaluating the impact of earnings per share (EPS) and dividend per share (DPS) on the market price per share (MPPS) of commercial banks that were listed on the Nepal stock exchange. Over a span of seven years, from 2016-2017 to 2022-2023, the study used a comprehensive dataset consisting of 210 panel data observations were meticulously compiled from the financial records of 10 commercial banks, selected from a total of 20 operating in Nepal. Descriptive statistics were conducted, and multiple linear regression models were also used to examine the effect of earnings per share and dividend per share on the market price per share. The findings of the regression analysis showed that while EPS and DPS account for 20.80 percent of the variation in MPPS, other factors account for 79.20 percent of the variation. Further, the outcome indicates that DPS and EPS have a statistically significant and favorable effect on MPPS. The study came to the conclusion that the DPS and EPS are important determinants of stock price and that they have a significant effect on Nepalese commercial banks' MPPS.
Evaluation of sustainability of a residential building using SVAGRIHA - a case of Mato Ghar
Authors: Adhikari Samiksha , B. Bajracharya Sushil
Published: July 2024

GRIHA, which stands for Green Rating for Integrated Habitat Assessment, is a rating system for large scale buildings. GRIHA was created to promote sustainable and eco-friendly practices in the construction and operation of buildings. GRIHA addresses various green building concepts in various  phases of buildings by using five ‘R’, i.e., recycle, reuse, reduce, refuse, and reinvent, to determine and encourage the sustainability of a building via rating. SVAGRIHA is a green rating system which falls under GRIHA, which is a rating system for small scale buildings. The study presented in this paper applies SVAGRIHA framework for determining the sustainability and green rating of Mato Ghar. This study has applied case study approach and chosen Mato Ghar as a suitable case study residence, as the requirements for using SVAGRIHA framework is for buildings with built-up area less than 2500 sq.m. Results showed that sustainability of a residence will be higher if it has used energy conservation as a part of the building lifecycle, energy efficient planning and design, active and passive strategies, and locally available materials. The methodology and findings in this research can also be replicated to determine the green rating of other residential buildings within and outside Kathmandu valley by architects and engineers in the process of residential building design.
Model Susceptible-Infected-Recovered (SIR) Dampak Penerapan PSBB Terhadap Kasus Covid-19 Di Pekanbaru
Authors: Soleh Mohammad Soleh , Melvy Utari Permadhi  , Wartono  , Irma Suryani  , Elfira Safitri  , Riry Sriningsih
Published: July 2024

Covid-19 has become a global pandemic in the 21st century. Various efforts to control its spread have been made. Isolation or regional quarantine is one of the efforts made by almost all countries in the world. Indonesia modified the lockdown by implementing 'Large-Scale Social Restrictions (PSBB)'. Before and during the implementation of PSBB, there have been many pros and cons in the community. By using the SIR model and Euler method, the impact before and after the implementation of PSBB in Pekanbaru city is compared. Based on daily data of Covid-19 cases in Pekanbaru city, it is obtained that the value of the basic reproduction number before and after the implementation of PSBB are  and  respectivel.  This condition confirms that either without or by implementing PSBB, Pekanbaru city will be free from Covid-19. Simulation of Covid-19 cases before and after PSBB graphically also shows a situation that will be free from disease. However, without implementing PSBB, the number of infected will jump drastically after some time even though it will eventually decrease, while by implementing PSBB there is no spike. Thus, the implementation of PSBB can be an alternative to control Covid-19.
Keywords: Basic reproduction number, Covid-19, PSBB, SIR model, Euler methods.
Minimum Spanning Tree Rute Shopping Mall Di Surabaya Menggunakan Algoritma Prim
Authors: Amalia Nabila Tasya , Novianti Fahriza , Yasmin Yasirah Rezqita Aisyah
Published: July 2024

Surabaya as the second most populous city in Indonesia often carries out developments on land, one of which is the construction of a shopping center. The large number of shopping center developments has made both local and foreign residents want to visit shopping centers in Surabaya. There are 9 most popular shopping centers used in this study. The purpose of this research is to determine the shortest route between shopping centers in Surabaya by using the prim algorithm. This algorithm determines the shortest route by forming a minimum spanning tree. The results obtained in this study are the shortest travel time from 9 shopping centers is 81 minutes with a distance of 31.5 KM.
 Keyword: Prim Algorithm, Graph, Rute, Surabaya
Peramalan Harga Saham PT. Bank Central Asia, Tbk dengan Menggunakan Metode ARIMA
Authors: Gubu La , Bakti Sadewa Muhammad Alfian , Pimpi La
Published: July 2024

The purpose of this research is to analyze the fluctuations and quantity of daily stock closing data of PT. Bank Central Asia Tbk (BCA) during the period from January 3, 2022, to December 30, 2022, and forecast the closing stock price in January 2023 using the ARIMA model. The research procedure was conducted step by step, including data collection, descriptive analysis, testing data stationarity, determining ARIMA model parameters, writing ARIMA equation models, conducting diagnostic tests on the best ARIMA model, and making predictions or forecasts. The analysis shows that the stock closing prices in 2022 fluctuated with an average range of Rp 7,214.29 - Rp 8,851.14 per share. The highest closing price occurred in November 2022, while the lowest occurred in July 2022. The forecast for the daily closing stock price of BCA from January 2 to January 31, 2023, using the ARIMA Model (1,1,0), ranges from Rp 8,550.00 to Rp 8,550.86. The MAPE value obtained from the forecasting result is 1.07%, indicating that the ARIMA model is highly effective in forecasting the closing stock price of BCA in January 2023. This research provides valuable insights into stock price fluctuations for stakeholders in the stock market.
Keywords: fluctuations, ARIMA, stock closing prices, forecast.
Katy Keene as a Ludic Site for Fashion and Self-Fashioning
Authors: Carroll Jane Suzanne
Published: July 2024

This article explores child readers of the Katy Keene comic as creators and designers of playful fashion. When Katy Keene launched in 1949, the editor, Bill Woggon, invited child readers to become co-creators of the comic’s content, calling on them to suggest storylines and to submit original designs for the clothes and accessories that Katy wore. Each published design included a line of text crediting the designer, and special issues featured profiles and photographs of readers, placing them centre stage in the comic alongside their heroine Katy. The paper dolls included in the comic invited further creative play, encouraging readers to continue the game of dressing Katy, America’s “Queen of Pin-Ups and Fashions,” at home. In this way, Katy Keene offered opportunities for both fashioning and self-fashioning, becoming a ludic space where children played with ideas and images of fashion, mixing pieces inspired by haute couture with outlandish inventions of their own. I argue that by enabling children to become creators of fashions, Katy Keene offered young readers the opportunity to develop their own aesthetic sense—both individually and as a community.
Breast Melanoma, a Disease Unsuspected by the Oncologists: Presentation of a Case Report and Review of the Literature
Authors: Macias-Diaz Salvador
Published: July 2024

Breast melanoma is a rare disease, with a clinical and histopathological presentation like usual breast carcinoma. We present the case report of a 40-year-old woman with the initial diagnosis of triple-negative breast carcinoma with a poorly differentiated tumor, she received neoadjuvant chemotherapy with anthracyclines and taxanes with no response, subsequently received carboplatin with a slight decrease in tumor size and surgery was possible, the histopathological report of the modified radical mastectomy with more extensive immunohistochemistry concluded melanoma, due to the delay in delivery of the pathology result, she was not a candidate for adjuvant immunotherapy due to extemporaneity. The breast melanoma is an uncommon disease, so it must be suspected in a tumor with a poorly differentiated histological grade and in the absence of response to chemotherapy, therefore, a larger immunohistochemical panel is suggested to have a more specific diagnosis.
Brain Tumor Autophagy: A New Breakthrough in Cancer Research
Authors: Trivedi Trupti
Published: July 2024

The term autophagy originates from a brace of Greek hitches, auto and phagy, where auto relates to one's own tone, and phagy refers to ingesting. Through a lysosome- suspended constrained medium, autophagy is the congenital, preserved crack-up of the cell that eliminates unwanted or imperfect factors. It enables the controlled cellular element breakdown and recycling. In cancer cells, autophagy prevents necrosis, which in amble reduces the preceding inflammation, which is accepted to hasten excrescence tumor, the medium causing this is quietly unknown. therefore, autophagy is presently appertained to as to command binary part as it prevents excrescence progression by precluding cancer cells from weathering and causing cell grave but, there are given autophagic pathways like PI3K- AKT- mTOR pathway which extend excrescence product. Collectively, it's set up that a blights in autophagy can usher to glioblastoma multiform, gliomagenesis, medulloblastoma, neural stem cells and numerous unlike excrescences in brain. In this review, we bandy the signification of pathways, modulators, and genes of autophagy in brain excrescences.
Diagnosis, Prognosis & Therapy of Hepatocellular Carcinoma
Authors: Haider Rehan
Published: July 2024

Tumors are labeled to stratify patients concerning their survival prognosis and to pickand provide optimized therapeutic options at any tumor stage. For hepatocellular carcinoma (HCC) the Barcelona Clinic Liver most cancers (BCLC) type has been followed as the international general, which is recommended using both the Yankee association for the examination of Liver sicknesses (AASLD) and the ecu affiliation for the take a look at of the Liver (EASL) (table 1). The BCLC type considers several aspects of the sickness: the affected person’s standard kingdom of health, the severity of the liver sickness, and the quantity of tumor spread (Llovet 1999) [1]. sufferers in levels, BCLC O and A have a significantly higher diagnosis than patients with advanced degrees of liver cancers (Mazzaferro 1996) [2] but roughly the Simplest 25% of patients with liver cancers are identified at an early stage. Each EASL (EASL 2012) [3] and AASLD guidelines provide tips concerning which therapy is perfect for patients at every stage of the BCLC class. unlike classification schemes in Different styles of malignancies, the BCLC class is especially useful because it's miles based on medical parameters – molecular characteristics cannot yet reliably assess The personal diagnosis of patients with HCC. The BCLC class appears to evaluate diagnosis less accurately in Asian sufferers, wherein hepatitis B is a triumphing motive of liver most cancers. An alternative type, the Hong Kong Liver Cancer Staging Machine (HKLC), has been proposed these days, which had a significantly better potential in Asian patients to differentiate subgroups with particular usual survival times (Yau 2014) [4]. Importantly HKLC identified subsets of sufferers with intermediate and advanced degrees of liver cancer, who would possibly benefit from extra-aggressive remedies (resection within the intermediate level, chemo embolization inside the advanced degree). Nonetheless to this point, the HKLC category is primarily based completely on retrospective records from Asian sufferers in a single middle and still awaits confirmation using prospectively managed studies and in non-Asian patients.
Pengasuhan Versi Orang Tua Denmark
Authors: Afriyenti Lenny Utama , Bangun Mic Finanto Ario , Saputra Raihan
Published: July 2024

Kegiatan dilakukan di TK Islam Bee, Sawangan Depok pada Januari tahun 2023 selama 2 hari. Tujuan kegiatan ini adalah untuk memberi edukasi serta wawasan baru kepada para orang tua siswa mengenai pengasuhan yang dilakukan oleh orang tua di Denmark. Seperti yang kita ketahui, bahwa masyarakat Denmark termasuk kedalam negara yang memiliki tingkat kebahagiaan tertinggi di dunia sehingga perlu untuk memahamkan kepada orang tua siswa mengapa alasan ini terjadi. Dari berbagai referensi disebutkan tentang jenis pengasuhan yang digunakan oleh orang tua Denmark terhadap anak-anaknya sebagai salah satu faktor munculnya kebahagiaan pada masyarakat Denmark dalam beberapa tahun terakhir. Diharapkan para orang tua memiliki pikiran yang open minded serta  bisa mengambil sisi positif bagaimana teknik pengasuhan orang tua versi masyarakat Denmark ini serta memperbaiki gaya pengasuhan keliru yang selama ini diimplementasikan kepada anak. Kegiatan dihadiri oleh orang tua (ayah dan ibu) serta guru. Banyak pertanyaan yang diajukan terkait dengan pengasuhan dan bagaimana memahami anak. Hasil dari kegiatan ini adanya peningkatan kemampuan kognitif dengan mampu menjawab pertanyaan yang diberikan serta adanya perasaan puas yang dirasakan oleh orang tua setelah kegiatan berlangsung.
LUNG VENTILATION FUNCTION AND PULMONARY GAS EXCHANGE IN ELDERLY PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE DURING COMBINED APPLICATION OF HYPOXIC TRAINING AND RESPIRATORY TRAINING WITH POSITIVE END-EXPIRATORY PRESSURE
Authors: Asanov Ervin O. , Shatilo Valeri B. , Dyba Iryna A. , Holubova Yuliia I. , Slipchenko Volodymyr H. , Poliahushko Liubov H.
Published: July 2024

Introduction. Treatment of chronic obstructive pulmonary disease (COPD) in elderly patients is often limited, leading to inadequate disease control. To enhance treatment effectiveness in elderly individuals with COPD, attention has been drawn to non-pharmacological methods, including hypoxic training and respiratory training with positive end-expiratory pressure (PEEP).
Aim. To assess the duration and effectiveness of combined application of hypoxic training and respiratory training with PEEP on lung ventilation function and pulmonary gas exchange in elderly patients with COPD.
Materials and methods. Forty-six elderly patients with COPD were examined: a group (15 individuals) with the application of respiratory training with PEEP, a group (15 individuals) with the application of hypoxic training, and a group (16 individuals) with the application of respiratory training with PEEP and hypoxic training. Before training, immediately after the training course, one month, and three months after the course of hypoxic and/or respiratory training with PEEP, lung ventilation function, bronchial patency, and blood saturation were determined.
Results. The application of hypoxic training and/or respiratory training with PEEP in elderly patients with COPD led to increased speed parameters reflecting bronchial patency. Also, after the course of hypoxic and/or respiratory training with PEEP, the FVC parameter increased in the examined patients, mainly due to ERV. Hypoxic training, compared to respiratory training with PEEP, had slight advantages in its effect on lung ventilation function in elderly patients with COPD. Application of INGT and/or breathing training with PEER resulted in an increase in SpO2. The combined application of hypoxic training and respiratory training with PEEP in elderly patients with COPD led to increased effectiveness and duration of therapeutic effect. The impact on bronchial patency and SpO2 of respiratory training with PEEP and/or hypoxic training was greater in patients with pronounced disease symptoms.
Conclusions. Separate application of respiratory training with PEEP or hypoxic training contributes to increased ventilation, decreased bronchial obstruction and increasing blood saturation, but the therapeutic effect is short-term and lasts no longer than a month. Meanwhile, the combined application of hypoxic training and respiratory training with PEEP in elderly patients with COPD leads to more significant improvement in ventilation and bronchial patency. At the same time, the duration of the therapeutic effect persists for three months. The effectiveness of respiratory training with PEEP and/or hypoxic training in elderly patients with COPD depends on the clinical symptoms of the disease: the more pronounced the symptoms, the greater the impact.