bluuebunny/crossref_metadata_2025 huggingface dataset:
The efficacy of computed tomography imaging-based radiotherapy for external auditory canal squamous cell carcinoma
Authors: Osu Naoto , Musha Atsushi , Yumisaki Hikaru , Okada Kohei , Kubo Nobuteru , Okano Naoko , Kawamura Hidemasa , Ohno Tatsuya
Published: June 2022

Background: External auditory canal (EAC) cancer is a rare disease for which there are no adequate evidence-based treatment strategies. Radical radiotherapy is often used as the initial treatment for EAC cancer from the viewpoint of organ preservation. This study aimed to elucidate the efficacy of radiotherapy for squamous cell carcinoma (SCC) of the EAC.Methods: Fifteen consecutive patients with SCC of the EAC who were treated with radical radiotherapy were retrospectively analyzed. The fractional dose was 2.0 or 3.0, and the total dose ranged from 66 to 70 Gy. Three-dimensional conformal radiation therapy was performed on seven patients. Intensity-modulated radiation therapy was performed on eight patients. Patients with T1 disease were treated with radiotherapy alone. Patients with T2-4 disease were treated with chemoradiotherapy.Results: The median follow-up period was 30.4 months. The 3 year local control (LC) rate for all patients was 51%, the disease-free survival (DFS) rate was 44%, and the overall survival (OS) rate was 73%. For T1-3 disease, the 3 year LC rate was 74%, DFS was 62%, and OS was 89%. However, for T4 disease, the 3 year LC rate was 17%, DFS was 17%, and OS was 50%. In a univariate analysis, only the T-category was a significant factor for predicting LC and DFS (p = 0.006 and 0.02, respectively). All local recurrences were within the high-dose irradiated area.Conclusions: The results of this study suggest that chemoradiotherapy is a reasonable first-line treatment for T1-3 SCC of the EAC. However, the efficacy of chemoradiotherapy in T4 cases was inadequate. Further research is warranted to elucidate the efficacy of treatments with more intensive antitumor effects for locally advanced EAC cancers.
Termites grown on seaweed media as dietary source of protein in the diets of African catfish (Clarias gariepinus)
Authors: Inyang-Etoh Aniema Paul , Eteng Sunday Urom , Ifon Honor Tajoes
Published: June 2022

A twelve-week feeding trial was conducted to examine the effect of termites grown on seaweed as a dietary protein source in the diets of African catfish (Clarias gariepinus). A total of 600 live African catfish specimens were used in the investigation, which were divided into four groups (ATD0, ATD1, ATD2, and ATD3) depending on their diets. The control diet (ATD0) was made with 60 percent commercial fishmeal (FM) and 40% soybean meal (SBM); ATD1, ATD2, and ATD3 were made with 60% crude protein obtained from termites (Macrotermes nigeriensis) grown on media containing only terrestrial grass (Cenchrus purpureus), only seaweed (Sagassum natans), and their combination (50:50), respectively. Results show that daily weight gain was higher in fish fed termite meal (ATM) based diets, while feed conversion ratio and viscerosomatic index were higher in control group. Inclusion of ATM in diets of African catfish did not affect nutrient digestibility, enzyme activities, and total bile acid levels in the different portions of the digestive tract. Essential amino acids and mineral composition of whole fish also showed insignificant differences between experimental groups. However, fatty acid composition in whole fish fed diet without termite meal was significantly lower than those fed diets containing termites grown on seaweed. The study concludes that raising catfish on feed made from termites grown on seaweed can provide a good source of essential fatty acids with high bioavailability potential in African catfish.
Morphological Analysis of Anterior Permanent Dentition in Chinese population via Cone-beam Computed Tomography
Authors: CHEN Yu , Lu Bingtai , Dai Yu , Yu Zujian , You Yuehua , Wu Bin , Yan Zhengbin
Published: June 2022

Background
Investigation of roots and canals is crucial in clinical assessment and treatment. Morphologies such as root length, cemento-enamel junction curvature (CEJ-C), root furcation and canal variations remain to be clarified.
Methods
In this retrospective study, we look into 4309 anterior teeth from 441 patients via cone-beam computed tomography (CBCT) in Chinese population, attempting to summarize the morphological characteristics of maxillary and mandibular anterior teeth.
Results
Maxillary (95% CI(mm): 13(16.57, 16.97), 23(16.31, 16.76)) and mandibular (95% CI(mm): 33(15.38, 15.72), 43(15.23, 15.57)) canines are observed with elevated root length compared with corresponding incisors (p < .0001, One-way ANOVA), while those of mandibular central (95% CI(mm): 31(12.07, 12.31), 41(12.10, 12.35)) and lateral (95% CI(mm): 32(13.23, 13.48), 42(13.27, 13.54)) incisor varied with significant difference (p < .0001, One-way ANOVA). The CEJ-C reveals significant increasement around incisors (95% CI(mm): 12(2.44, 2.60), 11(2.48, 2.63), 21(2.40, 2.55), 22(2.23, 2.39)) than canines (95% CI(mm): 13(1.95, 2.10), 23(1.83, 1.97)) in maxilla (p < .0001, Kruskal-Wallis). Root furcation is detected in mandibular canines and lateral incisors. Moreover, all types of Vertucci’s classification are noticed with two other new types.
Conclusions
The current findings help to optimize the root morphological understanding of Chinese population especially in endodontics. Moreover, CEJ-C facilitates clinical aesthetic interpretation and treatment in implantology and prosthodontic. However, further study should be carried out to investigate morphologies in-depth.
Nuclear orphan receptor ERRα promotes cisplatin resistance in breast cancer cells by targeting CCNE2
Authors: Liu Jiahui , Feng Jinwen , Xuan Junfeng , Huang Ling , Xiao Bin , Zhu Yi , Kuang Zhenzhan , Zhang Weiyun , Song Lijie , Zhou Ye , Wang Jie , Yang Chuanhong , Ding Chen , Zhang Hongbin , Li Linhai , Sun Zhaohui , Zhou Quan
Published: June 2022

Background
Chemotherapy is one of the most efficient therapeutic methods for cancer, but increasingly serious drug resistance is the main cause of cancer recurrence and treatment failure. Our study aimed to investigate the mechanisms by which upregulation of estrogen-related receptor α (ERRα) induced chemoresistance in breast cancer cells.
Methods
Immunohistochemistry (IHC) was used to determine the expression of ERRα in breast cancer and adjacent tissues. Functional analyses (in vitro and in vivo) were performed to confirm the role of ERRα in cancerogenesis and cisplatin chemoresistance in breast cancer. RNA-sequencing, ChIP-seq and dual luciferase assays were performed to identify the mechanisms by which ERRα promotes chemoresistance in breast cancer.
Results
ERRα was highly expressed in breast cancer tissues and the level of ERRα expression was determined to be significantly correlated with the expression level of human epidermal growth factor receptor 2 (HER2). Overexpression of ERRα promoted the proliferation and metastasis of breast cancer in vitro and in vivo while knockdown of ERRα suppressed. Moreover, ERRα was upregulated in chemoresistant breast cancer cells, while ERRα knockdown sensitized cisplatin treatment. Our results further demonstrated that ERRα enhanced the pluripotency of cancer cells and facilitated chemoresistance via upregulating CCNE2 by binding its promoter region. Overexpression of CCNE2 could reverse the sensitivity of breast cancer cells to cisplatin caused by ERRα depletion, thus resulting in accelerated tumor growth.
Conclusion
We identify that ERRα sustains the chemoresistance of breast cancer cells via regulating the transcription of CCNE2 and may serve as a therapeutic target in breast cancer.
Efficacy and Safety of Guselkumab and Adalimumab for Pustulotic Arthro-Osteitis and their Impact on Peripheral Blood Immunophenotypes
Authors: Ueno Masanobu , Miyagawa Ippei , Miyazaki Yusuke , Hanami Kentaro , Fukuyo Syunsuke , Kubo Satoshi , Nakayamada Shingo , Tanaka Yoshiya
Published: June 2022

Objectives: We compared the treatment effectiveness between guselkumab (GUS) and adalimumab (ADA) in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immunological background and analyzed the impact of therapeutic drugs to verify the validity of immunological phenotypes as therapeutic targets.Methods: Patients were treated with GUS 100 mg (GUS group; n = 12) and ADA 40 mg (ADA group; n = 13). Arthritis disease activity, skin lesion activity, and patient-reported outcomes (PROs) were evaluated and compared between the two groups. The retention rate and adverse events were evaluated. Comprehensive phenotyping of peripheral immune cells was performed in both groups, and phenotypes were compared before and after treatment.Results: At 6 months, both groups showed significant improvement in arthritis disease activity and PROs. In the GUS group, skin symptoms significantly improved. The 6-month continuation rates were 91.7% (11/12) and 69.2% (9/13) in the GUS and ADA groups, respectively. Adverse events occurred in 2/12 and 5/13 patients in the GUS (16.7%) and ADA (38.5%) groups, respectively. Peripheral blood immunophenotyping showed that the proportion of activated T helper (Th) 1 cells was significantly lower in patients with PAO than in healthy controls, and that the proportion of activated Th17 cells was significantly higher in patients with PAO, which significantly decreased after treatment with GUS.Conclusion: Although GUS and ADA have comparable efficacy for PAO, their impact on immunophenotypes varies. Precision medicine based on the immunological background of diseases should be considered.
Nutritional Security Aspects and Hygiene Practices among Street Food Vendors during Communicable Diseases Infection (COVID- 19 Pandemic)
Authors: Verma Ruchi , Mishra Sunita
Published: June 2022

Background: Nutritional security aspects and practicing good hygiene practices is an important component for ensuring human well-being. COVID-19, a global pandemic has had a bad effect on health of people around the world. Street food that is unsafe and unhealthy as it is sold in open areas could have been one of the causes of the spread of microbes, diseases. The aim of this study is to examine the knowledge of food nutritional security and hygiene practices among food vendors, during the Communicable Diseases (COVID- 19 Pandemic) that could have ensured consumer's health.Methods: A systematic questionnaire was used to collect the data, and sample randomly selected from Lucknow. Results were presented in terms of chi-square (χ 2) test, percentage, and p-value. Results: The result obtained by the compilation of the questionnaire shows that majority of handlers were well-versed about food hygiene. However, vendor lacked knowledge about cooking practices and storage of cooked food. It has been observed that 44 percent of food handler’s clean dirty utensils with soap and water, only 25% of food operators wash their hands in clean water each time before handling food, while 6 percent of operators used gloves while handling food. The overall food handler's food handling practices scores were lower than their knowledge scores based on the questionnaire responses. Conclusion: Results of the questionnaire shows that vendor has limited knowledge regarding nutritional security of the food and do not follow adequate hygiene practices, therefore awareness program should be promoted to increase knowledge of nutritional security and hygiene practices among vendors. The handlers should be made aware regarding fact of significance of nutritional security and hygiene practices to contain spread of microbes and communicable diseases.
TaqI polymorphism T/t genotypes at the vitamin D receptor gene (VDR) are associated with increased serum vitamin D levels in mild and moderate psoriasis vulgaris: A pilot study
Authors: Elneam Ahmed Ibrahim Abd , Al-Dhubaibi Mohammed Saleh , Bahaj Saleh salem , Mohammed Ghada Farouk
Published: June 2022

Background: Several types of polymorphisms in vitamin D receptor (VDR) have been found in psoriasis.Aim: this study looked at the role of the TaqI polymorphism in the VDR gene as a factor in changing plasma 25-hydroxyvitamin D (25(OH)D) levels in psoriasis patients and to see if it had any relationship with disease severity. Subjects and Methods: Clinical examination, serum (25(OH)D) levels measurement, molecular studies, TaqI genotyping by PCR and RFLP subjected for the two groups.Results: T/t genotypes of TaqI polymorphism genotypes were most common in patients, while t/t genotypes were more abundant in healthy subjects. The T allele was high in the patient group in comparing to the normal subjects, but there were no significant differences (P=0.421). Patients with T/t TaqI genotypes had higher levels of 25(OH)D) than T/T and t/t (P=0.004). Moderate psoriatic patients with the T/t genotype have relatively high 25(OH)D) levels than moderate patients with the T/t and t/t genotypes (P=0.001). Conclusion: The increase in 25(OH)D) titers in moderate patients is greater than that in mild and severe patients. T/t genotypes are associated with increased 25(OH)D) levels in moderate and mild patients.
Nocardia infection following ocular surface surgery
Authors: Wang Jingting , Lu Xiuhai , Wang Jungang , Wang Shuting , Shi Weiyun , Li Suxia
Published: June 2022

Objective: To investigate the clinical characteristics and treatment outcomes of Nocardia infection after ocular surface surgery. Methods: This is a retrospective study. Eight cases of culture-proven Nocardia infection, which developed within one month after ocular surface surgery were included. Demographics and clinical history of patients were investigated. Results: There were 8 eyes (2 left and 6 right) of 8 patients (5 males and 3 females), aged 27-65, with a median age of 52.9 years. Three cases underwent pterygium excision, three were subjected to conjunctival flap covering, and two were treated with lamellar corneal transplantation. The time interval between previous surgery and the onset of symptoms varied from 7 to 28 days (mean = 20.5 ± 7.13 days). All the cases presented grey-white infiltrates at the surgical incision site while appearing with six corneal ulcers and two conjunctival ulcers. Filaments of Nocardia were founded by confocal microscopy in two of the five cases. All responded poorly to medical therapy. Seven of the eight cases were treated with reoperation. Nocardia infection recurred in three cases after reoperation, and one was eviscerated.Conclusions: Surgical trauma is a risk factor for ocular Nocardia infection. Nocardia infection should be suspected when secondary infection occurs in a surgical incision with an atypical clinical presentation. Complete removal of lesions may lower the recurrence of Nocardia infection with poor drug treatment effects.
Dissecting the polygenic basis of atherosclerosis using disease associated cell state signatures
Authors: Örd Tiit , Lönnberg Tapio , Ravindran Aarthi , Niskanen Henri , Kiema Miika , Õunap Kadri , Maria Maleeha , Moreau Pierre , Mishra Pashupati , Palani Senthil , Virta Jenni , Liljenbäck Heidi , Aavik Einari , Roivainen Anne , Ylä-Herttuala Seppo , Laakkonen Johanna , Lehtimäki Terho , Kaikkonen Minna
Published: June 2022

Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into genetic basis of CAD require deeper understanding of the contributions of different cell types, molecular pathways and genes to disease heritability. Here, we investigate the biological diversity of atherosclerosis associated cell states and interrogate their contribution to the genetic risk of CAD using single cell and bulk RNA sequencing (RNA-Seq) of mouse and human lesions. We identified thirteen disease-associated cell states which we characterized further by gene set functional profiling, ligand-receptor prediction and transcription factor inference. Importantly, Vcam1+ smooth muscle cell state genes contributed most to SNP-based heritability of CAD. In line with this, genetic variants near smooth muscle cell state genes and regulatory elements explained the largest fraction of CAD risk variance between individuals. Using this information for variant prioritization, we derived a hybrid polygenic risk score (PRS) that demonstrated improved performance over a classical PRS. Our results provide insights into the biological mechanisms associated with CAD risk, which could make a promising contribution to precision medicine and tailored therapeutic interventions in the future.
Plano de gestão e geração de empregos verdes: uma alternativa para o Centro Histórico de Cuiabá-MT
Authors: MASCARO Luciana Pelaes , ALMEIDA Carla Cristina Rosa de , ROSSETI Karyna de Andrade Carvalho , DURANTE Luciane Cleonice
Published: June 2022

O Centro Histórico de Cuiabá-MT é reconhecido como Patrimônio Nacional pelo Iphan e encontra-se em processo de degradação, comprometendo as atividades econômicas da região. Diante desse quadro, elaborou-se um Plano de Gestão para o Centro Histórico de Cuiabá (PGCHC), no âmbito de uma ação conjunta entre governo, academia e Organização das Nações Unidas (UNIDO/ONU). O objetivo deste artigo é apresentar as diretrizes do PGCHC de forma sistematizada. A metodologia consiste em realização de diagnóstico socioeconômico e do ambiente construído, que subsidiou a posterior elaboração das propostas. Os setores econômicos âncoras a serem incentivados são educação, construção civil e comércios e serviços variados, com ênfase na economia criativa e turismo. A principal contribuição do estudo é o fornecimento de subsídios para a implementação de políticas públicas capazes de desencadear processo econômico gerador de empregos verdes vinculado à preservação do patrimônio cultural e ambiental da região.
Experimental study of a pilot unit of a ground regenerator for greenhouses
Authors: Mukminov Ihor , Volgusheva Natalya , Georgiesh Catherina , Boshkova Irina
Published: June 2022

The object of research: the process of heat exchange in a packing in the form of a dense layer of crushed stone as part of a thermal regenerator designed to utilize the low-grade heat of the air in a greenhouse.

Investigated problem: increasing the efficiency of air heat accumulation in the greenhouse during the daytime by a regenerative heat exchanger with a granular packing. Conducting experimental tests of regenerator models with a packing in the form of a dense layer of granular material under natural conditions is necessary to improve the design and optimize technological parameters.

The main scientific results: the analysis of temperature curves of air changes at the inlet and outlet of the regenerator installed in the mock-up greenhouse with a volume of 0.25 m3, and the packing material was carried out. During the heating period of the nozzle, the accumulated heat was Q=8•104 J, which can be used when the temperature in the greenhouse decreases. During the pause, the loss from the heat exchange channel to the environment is 48,000 J. The duration of the period was 358 min, while the average heat flux corresponded to 2.2 W. Heat losses during the pause period are significant due to its duration, however, the average heat transfer coefficient has a low value of k=2.3 W/m2K, so strengthening the insulation of the heat exchange channel is irrational.

The area of practical use of the results of the study: greenhouses, allowing the possibility of installing additional heat exchange equipment.

Innovative technological product: the innovativeness of the technical solution is determined by the possibility of using the heat of the air in the greenhouse and the implementation of contact heat exchange between the air flow and the packing particles. The design of the regenerator, the simplicity of its manufacture and operation, as well as the efficiency of air heat accumulation in the greenhouse during the daytime, allow to recommend it for use in greenhouse farms.

The scope of the innovative technological product: regenerative heat exchangers with a dense layer of granular material for the utilization of low-grade air flows generated in food production enterprises, ventilation systems and greenhouses
Aristotelova politika u horizontu mjere i odgoja
Authors: Senković Željko
Published: June 2022

U članku se razmatra grčki ideal mjere, najčešće izražen pojmom sredine. To nije samo svegrčki ideal nego drevna i svevremena baština, koja je konvergirala odgoju u ujednosti ‘dobrote i ljepote’. On je življen u polisu, kao što je bio i personalna, unutarduševna težnja. U Aristotelovoj politici počelo mjere prvenstveno je vezano (Pol. IV−VI) za balansiranje političkih poredaka (politička sredina), ali postoji i druga perspektiva (Pol. VI−VII) u kojoj je više riječ o vrlini i moralnim kvalitetama aristokracije, gdje se identificira dobrog čovjeka i građanina. Taj pristup srodniji je istraživanjama u Aristotelovim etičkim tekstovima (etička sredina). Pažljiva analiza ovih distinkcija iz knjige Politika zaključuje se s uvidima o odgoju (paideia) i vrlini kao komplementarnim aspektima praktičke filozofije.
Lithobiotic cyanobacteria diversity of the Karelian Isthmus
Authors: Rodina Oksana , Davydov Denis , Vlasov Dmitry
Published: June 2022

This work presents data obtained as a result of studying the composition of cyanobacteria in lithobiotic communities on various substrates (Ruskeala marble, rapakivi-granite, granite gneiss) in different light conditions on the territory of the Karelian Isthmus: Leningrad Oblast, Republic of Karelia, and South Finland. The species composition of cyanobacteria was revealed, and the species composition on certain types of substrates was analyzed. A total of 49 species of cyanobacteria were noted for the Republic of Karelia (13 of which were not previously recorded in this territory). The detailed taxonomic and environmental characteristics of species are given. Changes in the species diversity of cyanobacteria in connection with specific habitats are shown. The type of substrate, the degree of moisture, and illumination are noted as the main factors determining the diversity of cyanobacteria in lithobiotic communities.
Role of the MBP protein in myelin formation and degradation in the brain
Authors: Shenfeld Aleksandr , Galkin Alexey
Published: June 2022

The compact myelin sheath functions as an insulator for efficient conduction of nerve impulses. The formation of myelin sheaths around the axons of the most actively functioning neurons continues not only at the stage of brain development, but also in the process of learning and acquiring certain skills. Pathological or age-related disruption in myelin results in nerve conduction failure and neurodegeneration. Myelin Basic Protein (MBP) is the main constituent of the myelin sheath, representing about 30 % of the total myelin proteins in the central nervous system. Deletion in the MBP coding gene in mutant mice causes a severe neurological phenotype associated with rapid death of newborns. In this review, we discuss the current understanding of the role of the MBP protein in the formation of compact myelin and in neurodegeneration associated with demyelination.
CRISPR: A Promising Tool for Cancer Therapy
Authors: Mohammad-Rafiei Fatemeh , Safdarian Esmat , Adel Bashir , Vandchali Noushin Rezaei , Navashenaq Jamshid Gholizadeh , Gheibihayat Seyed Mohammad
Published: June 2022

The clustered regularly interspaced short palindromic repeats system, called
CRISPR, as one of the major technological advances, allows geneticists and
researchers to perform genome editing. This remarkable technology is quickly eclipsing
zinc-finger nucleases (ZFNs) and other editing tools, and its ease of use and accuracy
have thus far revolutionized genome editing, from fundamental science projects to
medical research and treatment options. This system consists of two key components: a
CRISPR-associated (Cas) nuclease, which binds and cuts deoxyribonucleic acid (DNA)
and a guide ribonucleic acid (gRNA) sequence, directing the Cas nuclease to its target
site. In the research arena, CRISPR has been up to now exploited in various ways
alongside gene editing, such as epigenome modifications, genome-wide screening,
targeted cancer therapies, and so on. This article reviews the current perceptions of the
CRISPR/Cas systems with special attention to studies reflecting on the relationship
between the CRISPR/Cas systems and their role in cancer therapy.
Association Between the Levels of Serum Free Testosterone and Lifestylerelated
Diseases in People Living with HIV
Authors: Yoshino Yusuke , Wakabayashi Yoshitaka , Kitazawa Takatoshi
Published: June 2022

Background:

Recently, male hypogonadism was reported to be prevalent in people living
with HIV (PLWH), even in cases diagnosed based on the serum free testosterone level (fTST).
However, studies on the management of PLWH showing the relationship between male hypogonadism
and lifestyle-associated diseases, are sparse.

Objective:

This study evaluated the relationship between serum fTST levels and lifestyle-related
diseases in virologically stable PLWH.

Methods:

This study was a retrospective cohort single-center study. The study included HIVinfected
men on antiretroviral therapy, with available data on serum fTST levels at Teikyo University
Hospital between June 2020 and September 2020. Clinical
information was collected at the time
of fTST measurement. A simple regression analysis was used to identify continuous variables significantly
associated with serum fTST levels. Student’s t-test and Mann-Whitney U test were also
used to identify non-continuous variables that were significantly correlated with serum fTST levels.

Results:

Sixty male patients were evaluated. The median age was 47 (40-62) years. Low serum
fTST levels were significantly associated with old age, low hemoglobin and total cholesterol levels,
and high hemoglobin A1c levels. Non-use of INSTI and comorbid hypertension were also significantly
associated with low serum fTST levels.

Conclusions:

Hypertension and the serum hemoglobin A1c level as a standard parameter for diabetes
was significantly associated with low serum fTST levels in Japanese male PLWH. This study
suggested that sex-hormone replacement therapy could be a preferred option for PLWH with low
serum fTST levels to manage their long-term complications.
Case Report of Sotalol Induced IgA Vasculitis
Authors: Mohammed Biniyam T. , Alchalabi Marwah , Laskova Anna , Sun Chenyu , Lodhi Owais , Gerais Yasmin , Abdelrahman Alkhidir Ayah Galal
Published: June 2022

Background:

IgA vasculitis is the most common form of systemic vasculitis in children
but can occur in adults. Inciting antigens include infections, drugs, foods, insect bites, and immunizations.
Antibiotics and tumor necrosis factor (TNF) alpha inhibitors are the most common class of
drugs that cause IgA vasculitis. Although sotalol and rivaroxaban have been documented to cause
leukocytoclastic vasculitis, we have never come across any literature attributing IgA vasculitis to
either drug. Additionally, Rocky Mountain spotted fever has not been associated with IgA vasculitis
despite being described in cutaneous and systemic vasculitis cases. Here, we present a case of IgA
vasculitis triggered by sotalol with challenging differentials, including a recent infection with Rocky
Mountain spotted fever, malignancy, and rivaroxaban as possible triggers.

Case Presentation:

68 yr old male with a history of lung cancer treated with resection and chemotherapy
5 years ago is currently in remission, and recently was started on sotalol and rivaroxaban for
new-onset paroxysmal atrial fibrillation. He presented with diffuse petechial/purpural rash on the
lower limbs, multiple joint pain, severe abdominal pain and rectal bleeds, hemoptysis, and renal
dysfunction. IgG titers for RMSF were high. Punch biopsy of skin and renal biopsy were consistent
with IgA vasculitis. Sotalol and rivaroxaban were stopped. The patient was treated with oral prednisone,
and his condition relatively improved.

Conclusion:

Ig A vasculitis is mostly a self-limiting disease, but adults tend to have a severe
course. It is important to diagnose early and identify a trigger. Removing the offending agent or
treating the underlying infection is an important aspect of management.
PSSD and Biologic Therapy: Real-Life Data in 417 Patients with Moderate
to Severe Psoriasis
Authors: Proietti Ilaria , Bernardini Nicoletta , Skroza Nevena , Mambrin Alessandra , Tolino Ersilia , Marchesiello Anna , Marraffa Federica , Rossi Giovanni , Volpe Salvatore , Potenza Concetta
Published: June 2022

Background:

Psoriasis is a chronic relapsing immune‐mediated disease leading to a strong impact on patient’s quality of life. The treatment of psoriasis has undergone a revolution with the advent of biologic therapies. Currently, Psoriasis Area and Severity Index [PASI] and Dermatology Life Quality Index [DLQI] scores are in use to assess the overall severity of pathology. A new self- administered questionnaire, the Psoriasis Symptoms and Signs Diary (PSSD), assesses severity of six psoriasis symptoms (itch, skin tightness, burning, stinging, and pain,) and five signs (dryness, cracking, scaling, shedding/flaking, redness, and bleeding).

Objective:

To evaluate and compare the efficacy of biologic therapies through PSSD in patients with moderate to severe psoriasis.

Methods:

The PSSD questionnaire was administered to all the patients at the beginning and after 6 months of biologic therapy (anti-TNFalpha, anti- IL17, anti-IL23, anti-IL12/23 and phhosphodiesterase-4 Inhibitors).

Results:

The study population included 417 adult patients with moderate to severe psoriasis in treatment with biologic drugs. All the drugs contributed to a significant improvement of mean total PSSD at t 24; anti-IL17 and anti-IL23 led to a significantly greater reduction at t 24 mean PSSD when compared to other therapies.

Conclusion:

The PSSD, is a new validated instrument useful for capturing psoriasis patient’s quality of life and evaluating treatments efficacy. In our study this score has been useful to put in evidence significant differences between biologic drugs.
The Law and Politics of Protecting Liberal Democracy
Authors: Morijn John
Published: June 2022

Inaugural lecture by prof. mr. dr. on 24 june 2022 on acceptance of the post of endowed professor of Law and politics in international relations at the Faculty of Law. This inaugural lecture discusses the law and politics of protecting liberal democracy in Europe. It is in three parts. It first discusses the nature of the current challenge to liberal democracy. It then addresses the law in place to protect it (better) and identifies ways to improve the record. Finally, it reflects on the politics needed to bridge the gap between binding law and current realities. The lecture presents three arguments. First, the problem of deterioration of liberal democracy in EU Member States and, as a result, political EU institutions themselves, is deeper and more urgent than commonly understood. Opponents of liberal democracy have a clear gameplan. Its defenders do not – at least not yet. Second, existing binding norms and EU procedures offer more possibilities to protect liberal democracy than used. The challenge is to employ only those tools that are effective and to enforce their outcomes more effectively – particularly judgments of the European Court of Justice. Third and finally, there is a need for more, not less politics to protect liberal democracy. But politics cannot be left to politicians alone. Instead, more conscious and coordinated action from all of us is required. Lawyers and politicians have an additional responsibility.
Effect of Switching Antiretroviral Treatment Regimen in Patients With Drug-Resistant HIV-1 Infection: Retrospective Observational Cohort Study
Authors: Li Yiping , Wang Qinjian , Liang Shu , Feng Chuanteng , Yang Hong , Yu Hang , Yuan Dan , Yang Shujuan
Published: June 2022

Background

Evidence on the efficacy of antiretroviral therapy (ART) regimen switches on the mortality of patients with HIV drug resistance (HIVDR) is limited.

Objective

We aim to provide policy guidance for ART regimen selection and evaluate the effectiveness of ART regime switches for people living with HIV and HIV-1 drug resistance.

Methods

This retrospective observational cohort study included 179 people living with HIV and HIV-1 drug resistance from 2011 to 2020. The time that participants switched treatment regimens either to protease inhibitor (PI)–based ART regimens (PIs) or nonnucleoside reverse transcriptase inhibitor (NNRTI)–based ART regimens (NNRTIs) was taken as an observation starting point and followed up every 12 months. The parametric g-formula was used to estimate the 5-year risk of mortality under the situations of (1) natural course, (2) immediate switch to NNRTIs, (3) immediate switch to PIs, and (4) if CD4(+) T cells<200 switched to PIs.

Results

The follow-up time of the 179 patients ranged from 30 to 119 months. The median follow-up time was 90 months. During a follow-up of 15,606 person-months, 27 individuals died in the cohort. The estimated 5-year risk of mortality under natural course, immediate switch to NNRTIs, immediate switch to PIs, and if CD4(+), and switch to PIs if T cells<200 were 11.62% (95% CI 7.82-17.11), 31.88% (95% CI 20.79-44.94), 2.87% (95% CI 0.32-7.07), and 5.30% (95% CI 2.07-10.21), respectively. The risk ratios (RRs) of immediate switch to NNRTIs, immediate switch to PIs, and switch to PIs if CD4(+) T cells<200, compared with natural course mortality rate, were 2.74 (95% CI 2.01-3.47), 0.25 (95% CI: 0.04-0.54), and 0.46 (95% CI 0.22-0.71), respectively. The risk differences were 20.26% (95% CI 10.96-28.61), –8.76% (95% CI –13.34 to –5.09) and –6.32% (95% CI –9.75 to –3.11), respectively.

Conclusions

Our study found that a PI-based ART regimen was beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. More effort should be given to find HIV-1 drug resistance earlier to ensure a timely adjustment to PI-based ART, thereby maximizing the benefit of early switch treatment for people living with HIV and HIV-1 drug resistance.
Health effects of secondhand smoke on children under 5 years of life
Authors: Kovalenko D.A.
Published: June 2022

Background. The high prevalence of smoking among adults suggests the almost inevitable effects of second-hand tobacco smoke (SHS) on children and adults who do not smoke. The negative effects of SHS are most pronounced in young children, especially in families where the mother is a smoker. The aim was to assess the effects of prenatal and postnatal exposure to SHS in children under five years of life. Materials and methods. The survey among 520 families with children was conducted using online self-reported questionnaire. Families with extremely and very preterm children and children with inherited diseases of bronchopulmonary system were excluded from the analysis. During the analysis, all children (n = 414; 55.07 % of boys and 44.93 % of girls, mean age — 36.38 ± 7.19 months) were divided according to SHS exposure. 186 children exposed to SHS were included in the main group, and 228 children without SHS exposure — in the control group. Results. 22.46 % of children were prenatally exposed to SHS. Maternal smoking during pregnancy significantly increased the risk of the intrauterine growth retardation (IUGR) (OR 2.43 [95% CI 1.07–5.52]). Postnatal exposure to SHS was present in 56.52 % of children. These children were significantly more likely to be formula-fed (OR 1.75 [95% CI 1.15–2.65]). The frequency of formula feeding was significantly increased by mothers’ use of both traditional tobacco products and electronic nicotine delivery systems (OR 2.10 and 2.99, respectively). Exclusively maternal smoking in the family increased the risk of frequent acute respiratory viral infections (ARI) in 3 years old children more than 1.5 times (OR 1.60 [95% CI 1.01–2.60]). Household SHS exposure increased the probability of bronchial obstruction (BO) during ARI in a child in 1.61 times, while exclusively maternal smoking increased the risk in 2.88 times. An increased risk of frequent ARI (OR 3.25 [95% CI 1.68–6.28]) was also present in the subgroup of children whose mothers smoked electronic nicotine delivery devices. The use of traditional tobacco products and electronic nicotine delivery systems, both by mothers and other family members, has significantly affected the risk of developing BO in children with respiratory disease. Conclusions. Maternal smoking during pregnancy in the studied cohort is a proven risk factor for IUGR. Household smoking is statistically likely to affect the incidence and likelihood of developing BO in children of the first five years of life, regardless of the type of tobacco product. This risk is greatest among children whose mothers are smokers.
Diagnostic value of functional tests in determining the condition of the cardiorespiratory system
Authors: Otmen M. Ben , Nechytailo Yu.M.
Published: June 2022

Background. The purpose was to study the nature of changes in the cardiorespiratory system in the case of short-term hypoxemia during functional tests with breath-holding. Materials and methods. The paper presents the results of a survey of school-age children with acute bronchitis with and without obstructive syndrome (60 patients) and a group of healthy children (52 people). Patients underwent pulse oximetry in combination with hypoxic tests for breath-holding with data recording on a computer and performed a Rufier test. Results. The severity of bronchitis in patients in the first days was average on the BSS-ped scale — 7.79 ± 0.19 points. The level of blood oxygen saturation was normal (above 95 %), but there was a difference between the groups: in patients with obstructive syndrome it was 98.60 ± 0.04 %, in the absence of this syndrome — 98.80 ± 0.03 %, which was lower than in the control group — 99.00 ± 0.01 % (p < 0.05). Time of breath-holding did not differ significantly between groups, but there was a slight decrease in saturation after them. There was greater reaction to breath-holding on exhalation. Level of oxygenation in patients with bronchitis achieved by increasing heart rate. Due to the phenomena of relative hypoxemia of peripheral tissues during convalescence, there was a decrease in tolerance to physical loading after the Rufier test. Conclusions. It is established that even in mild forms of acute bronchitis in children, according to functional tests, there is a decrease in gas exchange reserves, especially in the presence of obstructive syndrome. Compensatory mechanisms to maintain blood saturation are based on increasing systemic blood flow due to increased heart rate.
Mastocytosis. General concepts, view on patient management, examples of clinical course of the disease
Authors: Statkevych O.L. , Sviatenko T.V.
Published: June 2022

Background. Mastocytosis is a disease characterized by the presence of mast cells in various organs. The skin is affected most often. Almost every patient diagnosed with mastocytosis has skin lesions. This disease is characterized by redness, itching, abdominal pain, diarrhea, musculoskeletal pain, hypotension. These features result from the release of the mast cell mediator and its infiltration into the target organs. Materials and methods. This article describes the symptoms and signs of each and systemic mastocytosis, the principles of their diagnosis, based on recently published іnternational recommendations. Results. According to the 2016 World Health Organization classification, mastocytosis can be divided into cutaneous mastocytosis, systemic mastocytosis and mast cell sarcoma. Cutaneous mastocytosis is divided into three subtypes: maculopapular cutaneous mastocytosis, diffuse cutaneous mastocytosis and cutaneous mastocytoma. Permanent telangiectasia of the macular eruptive form is no longer considered a separate unit. Systemic mastocytosis, in turn, is also divided into indolent, smoldering, aggressive and associated with hematological tumors. Conclusions. Cutaneous manifestations of mastocytosis may vary with age. The classification of cutaneous mastocytosis has recently been updated. As a rule, in patients with mastocytosis in childhood the disease occurs as cutaneous mastocytosis and spontaneously regresses during puberty. On the contrary, in adult patients, despite skin lesions, systemic lesions are often observed, and the course of the disease is usually chronic. That is, patients of any age can be affected. The article describes the causes and pathogenesis of mastocytosis with an overview of clinical features, approach to diagnosis and therapy depending on age and severity of the disease. Clinical cases for visual acquaintance with a clinical picture of various forms of mastocytosis are resulted.
Human Beings and Social Structure in Frantz Fanon’s Philosophical Thought
Authors: Wijanarko Robertus , Saeng Valentinus
Published: June 2022

In response to the Colonial discriminative and exclusive concept of humanism, Frantz Fanon, an Algerian postcolonial thinker, proposes that the idea of humanism needs to be inclusive. To avoid the trap of the essentialist concept of humanism, Fanon argues that our understanding of human beings needs always to be connected with the existing social structure. By utilizing a postcolonial theory as a lens of analysis, this study will explore Frantz Fanon’s existential concept of human existence and investigate his philosophical-political thoughts. This exploration is driven by these critical questions: how is Fanon’s new understanding of the existential concept of human existence, which he proposes as a more inclusive concept? How does Fanon draw the correlation between human existence and social structure? What is the significance of his thoughts to critically investigate the socio-political structure in the postcolonial Indonesia? Our critical research will focus mainly on several of Fanon’s works: The Wretched of the Earth, Toward the African Revolution, and Black Skin White Masks. His other works will certainly be considered. We will utilize a litterer critical analysis method in approaching these works of Fanon. This new concept of Fanonian humanism, we argue, gives a theoretical frame and direction to develop existentially our understanding of an inclusive Indonesian humanism.
Abstracts from the 2022 AMSA Reciprocal Meat Conference
Authors:   American Meat Science Association
Published: June 2022

Abstracts from the 2022 AMSA Reciprocal Meat Conference
UTICAJ PARTIJSKE IDEOLOGIJE NA NIVO SOCIJALNIH TRANSFERA U BIVŠIM SOCIJALISTIČKIM DRŽAVAMA
Authors: Bursac Dejan
Published: June 2022

Autor u radu analizira uticaj bazične ideološke podele vladajućih partija između levice i desnice na kretanje nivoa budžetske potrošnje u segmentu socijalnih transfera, u okviru izabranog uzorka od jedanaest bivših socijalističkih država Centralne i Istočne Evrope. Više studija se bavilo ovom korelacijom u prošlosti, uglavnom utvrđujući pozitivan uticaj ideološke komponente na potrošnju, i to u očekivanom maniru: dok su stranke desnice rezale potrošnju, levica na vlasti je obično vodila ekspanzivnu budžetsku politiku. Ipak, većina tih istraživanja fokusirala se na razvijene zapadne demokratije, dok je tek manji broj analizirao ovu korelaciju u slučaju post-socijalističkih država, a štaviše, autori potonjih studija su dolazili do različitih, često suprotstavljenih rezultata. Nalazi ovog rada potvrđuju glavne hipoteze o vezi partijskog faktora i socijalnih budžeta: ali, iako je partijska ideologija važna i utiče na nivo socijalnih transfera, postoje i drugi značajni prediktori potrošnje u ovoj oblasti: institucionalne, ekonomske i demografske varijable.
TRANS – U SVETU
Authors: Bratina Boris
Published: June 2022

Trans-humanizam, trans-estetika, trans-seksualnost i druge trans-fraze kao da hoće nešto od nas. Ono što žele, to se i praktikuje na totalitetu subjektivnosti. Ceo svet kao da je pao u trans. Trans o kome ovaj rad govori je sveprisutni zahtev, ali to prelaženje i prekoračenje koje on evocira mnogo je manje mistično u odnosu na mađiju. Ipak, trans u koji moramo pasti sačinjavaju radnje koje treba da nas u to stanje stave. Za to je potrebna čitava tehnika, koja očevidne stvari čini beznačajnim, dok se smisao značaja delovanja pomera na akcentuaciju stvari koje treba da promene ljudsku prirodu i uskrate njene potencijale. U tom smislu, rad hoće da pokaže medijske tehnike, pa i da ukaže na upotrebu hemijskih preparata, koji te „tehnike“ dopunjuju u cilju ostvarivanja nedelatnog transa, takvog da doprinosi u obezbeđivanju reprodukcije vladajućeg poretka, globalno. Izazivanje transa i njegovo vrednosno promovisanje radi na visokim frekvencijama (ne)svesti sa visokim učinkom i menja svaku osnovu identiteta kada je reč o „pogledu na svet”. Postoje li kontra-tehnike ili pristupi koji bi savremenu krizu, shvaćenu pre svega kao krizu identiteta, mogli zaustaviti, tj. vratiti svest izvornom promišljanju koje je čoveku prirođeno?
SRBI U VOJSCI RUSKOG CARA MIHAILA ROMANOVA 1628–1633. GODINE
Authors: Radusinovic Milorad
Published: June 2022

Među državnim aktima iz vremena Moskovske Rusije (Moskovije) sačuvali su se i oni koji govore o učešću i stranaca u redovima carske vojske u doba cara Mihaila Romanova. Među njima se, pored ostalih, pominju i Srbi. Svi oni su se izdržavali na račun carske blagajne, uživajući kao ratnici određene privilegije. Rusija je rado primala u svoju vojsku lojalne strane plaćenike, birajući one koji u ratnim okolnostima ne bi nanijeli štetu ruskoj državi.
УПРАВЛЕНИЕ ПРОГИБОМ СТРУКТУР КРЕМНИЯ В ТЕХНОЛОГИИ ХЛОРИДНЫХ ГАЗОТРАНСПОРТНЫХ РЕАКЦИЙ
Authors: Тарасов Д.В. , Баранов Ю.Н. , Федотов С.Д. , Соколов Е.М. , Стаценко В.Н. , Гаврилов С.А.
Published: June 2022

В данной работе исследованы зависимости механических свойств поликристаллических слоев кремния от температуры роста слоя при осаждении их методом химического газотранспортного переноса (CVT). Установлено, что основным технологическим параметром, определяющим величину и направление прогиба кремниевых структур, является температура роста поликристаллического слоя кремния.
ВЫСОКООМНЫЕ СТРУКТУРЫ GAAS-ALGAAS ДЛЯ СИЛОВОЙ ЭЛЕКТРОНИКИ
Authors: Крюков В.Л. , Леви А.В.
Published: June 2022

Рассмотрены особенности конструкции высокоомных p-i-n-структур на основе системы GaAs-AlGaAs и способа их выращивания методом жидкофазной эпитаксии, позволяющие реализовать силовые диоды, существенно превосходящие по совокупности основных параметров лучшие кремниевые аналоги.
ГЕТЕРОСТРУКТУРЫ GAAS-ALGAAS ДЛЯ ПРИБОРОВ ПЕРСОНАЛИЗИРОВАННОЙ МЕДИЦИНЫ
Authors: Крюков В.Л. , Крюков Е.В. , Васильчиков А.С.
Published: June 2022

Проведены исследования совокупности технологических факторов, позволяющих получать специализированные гетероструктуры GaAs-GaAlAs с высокой мощностью излучения, малым отклонением длины волны электролюминесценции от номинального значения (не более ±3 нм) и высокой стабильностью параметров в процессе эксплуатации, предназначенные для использования в приборах персонализированной медицины.
ИСПОЛЬЗОВАНИЕ МЕТОДОВ СТАТИСТИЧЕСКОГО ПРОГНОЗИРОВАНИЯ ДЕГРАДАЦИИ ПАРАМЕТРОВ СХЕМЫ ДЛЯ ОЦЕНКИ ПОКАЗАТЕЛЕЙ НАДЕЖНОСТИ
Authors: Соловьев А.В. , Селецкий А.В.
Published: June 2022

В работе рассмотрена методика расчета показателей надежности при ускоренных испытаниях изделий посредством анализа деградации их параметров - критериев годности. Приведены основные результаты использования метода трендов при испытаниях на безотказность и сохраняемость.
УЧЕТ СВОЙСТВ МАТЕРИАЛОВ ПРИ МОНТАЖЕ КРИСТАЛЛА КАК ВАЖНЫЙ ФАКТОР ЭФФЕКТИВНОСТИ ОТВЕДЕНИЯ ТЕПЛА ОТ МИКРОСБОРКИ
Authors: Кадыров В.Н.
Published: June 2022

Выполнены обзор и анализ методов монтажа кристаллов, физических свойств поверхностей и соединительных материалов. Выделены перспективные решения с точки зрения теплопроводности. Продемонстрирован пример технологии сборки модуля с усилителем мощности, обозначена роль импортных материалов.
ОСОБЕННОСТИ ПРОЕКТИРОВАНИЯ И МОНТАЖА СИСТЕМ РАСПРЕДЕЛЕНИЯ ДЕИОНИЗОВАННОЙ ВОДЫ В СТАНЦИЯХ ВОДОПОДГОТОВКИ ДЛЯ ПРЕДПРИЯТИЙ ЭЛЕКТРОННОЙ ОТРАСЛИ
Authors: Сафонова Д.А.
Published: June 2022

Рассмотрены общие моменты проектирования и монтажа систем распределения деионизованной воды в станциях водоподготовки для предприятий электронной отрасли, даны особенности в зависимости от марки деионизованной воды, определены позиции, влияющие на бюджет и сроки оснащения.