bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Mass Media Entrepreneurship Education on Entrepreneurial Mindset and Intentions
Authors: Seoke Seipati , Mamabolo Anastacia , Mtotywa Matolwandile M.
Published: November 2023

The existing research has focused on the role of traditional entrepreneurial education in promoting entrepreneurship. This study suggests that mass media radio entrepreneurial education, which is underexplored, fosters the development of an entrepreneurial mindset and intentions. As such, this study investigated how mass media entrepreneurial education influences entrepreneurial intentions through the development of entrepreneurial mindsets. Cross-sectional quantitative research was conducted on a final sample of 702 potential entrepreneurs in South Africa. Correlation analysis and structural equation modeling were used to analyze the data. The results of the study showed a strong positive relationship between some dimensions of mass media entrepreneurial education, an entrepreneurial mindset, and intentions. Entrepreneurial mindset derived from mass media education had a significant impact on entrepreneurial intentions. In addition, the entrepreneurial mindset mediates some dimensions of mass media entrepreneurial education and entrepreneurial intentions. The study showed alternatives to traditional entrepreneurial education programs. Mass media can be used as an alternative when formal entrepreneurial education is limited.
Was punk DIY? Is DIY punk? Interrogating the DIY/punk nexus, with particular reference to the early UK punk scene, c. 1976–1984
Authors: McKay George
Published: November 2023

This article offers a critical provocation and reconceptualisation of the DIY/punk nexus, both to challenge the standard critical narrative of punk as originary DIY culture and to liberate the broader practice of DIY from the limits of punk. It critically traces the development of the discourse of DIY both in original British punk c. 1976–1984 and in what has become punk studies, mapping the development of the scholarly orthodoxy. It then challenges the latter via an interrogation of aspects of punk that have been repeatedly presented in the scholarship as evidence of its DIY-ness: punk mediation, instrumentation, and participation. These three then constitute a context for the central and more detailed critical exploration of the most widely accepted DIY/punk practice, the independent or self-produced record, which is also read as ‘non-DIY.’ The article concludes by widening the critical gaze via a call for DIY to undergo a process of depunking.
Seeing democracy like a city
Authors: Beveridge Ross , Koch Philippe
Published: November 2023

Urbanisation is changing landscapes, social relations and everyday lives across the globe. But urbanisation is also changing the ways democracy is understood and practiced. Nevertheless, the relation between urbanisation and democracy remains conceptually and empirically underdeveloped. Our aim in this paper is to provide a novel way of thinking about this relationship that addresses two limitations in current debates. First, there is the dominant view that just as urbanisation dissolves the actual, material city it also dissolves the city as a democratic project. We challenge this understanding, arguing that across the globe claims for and forms of urban collective self-rule signal that the city retains democratic significance in a very specific sense: as an object of practice and thought the city is a source and stake of the urban demos. Second, there is a tendency to either restrict the question of democracy to state-centred forms of political action or to place democracy completely outside the realm of the state. We argue however that urbanisation unsettles seemingly fixed boundaries between the state and society and thus opens the possibility of weaving together a new democratic fabric encompassing both. In addressing these two strands of debate together, we outline a democratic politics of urbanisation that shifts perspectives from institutions to practices, from jurisdictional scales to spaces of collective urban life. Seeing democracy like a city, we argue, foregrounds a way to reimagine and to re-locate democracy in the everyday lives of urbanites.
Value of inferior vena cava collapsibility index as marker of heart failure in chronic obstructive pulmonary disease exacerbation
Authors: Kouraichi Cyrine , Sekma Adel , Bel Haj Ali Khaoula , Chamtouri Ikram , Sassi Sarra , Toumia Marwa , Yaakoubi Hajer , Youssef Rym , Msolli Mohamed Amine , Beltaief Kaouthar , Mezgar Zied , Khrouf Mariem , Bouida Wahid , Dridi Zohra , Boukef Riadh , Boubaker Hamdi , Grissa Mohamed Habib , Nouira Semir
Published: November 2023

Introduction

Inferior vena cava (IVC) diameter variability with respiration measured by ultrasound was found to be useful for the diagnosis of heart failure (HF) in ED patients with acute dyspnea. Its value in identifying HF in acute exacerbation of chronic obstructive pulmonary disease exacerbation (AECOPD) was not specifically demonstrated.

Objective

To determine the value of ΔIVC in the diagnosis of HF patients with AECOPD.

Methods

This is a prospective study conducted in the ED of three Tunisian university hospitals including patients with AECOPD. During this period, 401 patients met the inclusion criteria. The final diagnosis of HF is based on the opinion of two emergency experts after consulting the data from clinical examination, cardiac echocardiography, and BNP level. The ΔIVC was calculated by two experienced emergency physicians who were blinded from the patient’s clinical and laboratory data. A cut off of 15% was used to define the presence (< 15%) or absence of HF (≥ 15%). Left ventricular ejection fraction (LVEF) was also measured. The area under the ROC curve, sensitivity, specificity, and positive and negative predictive values were calculated to determine the diagnostic and predictive accuracy of the ΔIVC in predicting HF.

Results

The study population included 401 patients with AECOPD, mean age 67.2 years with male (68.9%) predominance. HF was diagnosed in 165 (41.1%) patients (HF group) and in 236 patients (58.9%) HF was excluded (non HF group). The assessment of the performance of the ΔIVC in the diagnosis of HF showed a sensitivity of 37.4% and a specificity of 89.7% using the threshold of 15%. The positive predictive value was 70.9% and the negative predictive value was 66.7%. The area under the ROC curve was 0.71(95%, CI 0.65–0.76). ΔIVC values were not different between HF patients with reduced LVEF and those with preserved LVEF.

Conclusion

Our results showed that ΔIVC has a good value for ruling out HF in ED patients consulting for AECOPD.
Predicting the risk of early bleeding following endoscopic variceal ligation in cirrhotic patients with computed tomography
Authors: Ryu Hwaseong , Kim Tae Un , Yoon Ki Tae , Hong Young Mi
Published: November 2023

Background

Life-threatening bleeding following endoscopic variceal ligation (EVL) in patients with cirrhosis rarely can occur. The present study aimed to evaluate the performance of computed tomography (CT) in predicting the risk of early bleeding following EVL in cirrhotic patients.

Methods

We retrospectively investigated 285 cirrhotic patients who had undergone EVL. EVL was performed for prophylaxis or acute variceal bleeding. The patients were classified into 2 groups: early bleeding (< 14 days after EVL) and non-early bleeding. We compared baseline characteristics including CT findings between the patient groups.

Results

Among the 285 patients who underwent EVL treatment, 19 patients (6.7%) experienced early bleeding. On average, these bleeding occurred 9.3 ± 3.5 days after the EVL, with a range of 3 to 13 days. Patients who experience early bleeding had a higher six-week bleeding-related mortality rate compared to those in the non-early bleeding group (31.6% vs. 10.2%; p = 0.014). There was a correlation between the grade of esophageal varix observed during endoscopy and the diameter of esophageal varix observed on CT (p < 0.001). The diameter of esophageal varix on CT was identified as the only significant predictive factor for early bleeding (p = 0.005).

Conclusion

A larger esophageal varix diameter observed on CT is associated with an increased risk of early bleeding after EVL treatment. Early identification of this high-risk group can provide a change of treatment strategies to improve patient outcomes.
Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies
Authors: Hasani Motahareh , Alinia Seyedeh Parisa , Khazdouz Maryam , Sobhani Sahar , Mardi Parham , Ejtahed Hanieh-Sadat , Qorbani Mostafa
Published: November 2023

Background

The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer.

Methods

We systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I2. A random-effects model meta-analysis was conducted to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by subgroup and meta-regression analysis.

Results

Totally, 15 studies (9 case–control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case–control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity.

Conclusion

Our results show an inverse and significant association between higher OBS and odds of colorectal cancers in case–control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results.
Estimated cardiorespiratory fitness and incident risk of cardiovascular disease in China
Authors: Liu Yuanjiao , Zhu Jinghan , Guo Ziye , Yu Jiazhou , Zhang Xuhui , Ge Huiqing , Zhu Yimin
Published: November 2023

Background

Limited evidence is available on the association between estimated cardiorespiratory fitness (e-CRF) and incidence of cardiovascular disease (CVD) in Chinese population.

Methods

A total of 10,507 adults including 5084 men (48.4%) and 5423 (51.6%) women with a median age of 56.0 (25% quantile: 49, 75% quantile 63) years from the China Health and Retirement Longitudinal Study (CHARLS) was recruited in 2011 as baseline. The CVD incident events were followed-up until 2018. e-CRF was calculated from sex-specific longitudinal non-exercise equations and further grouped into quartiles. Cox proportional models were used to calculate hazard ratio (HR) and 95% confidence interval (CI) for incidence risks of CVD, heart disease and stroke.

Results

During a median follow-up of 7 years, a total of 1862 CVD, 1409 heart disease and 612 stroke events occurred. In fully adjusted models, each one MET increment of e-CRF was associated with lower risk of CVD (HR = 0.91, 95%CI = 0.85–0.96 for males, HR = 0.87, 95%CI = 0.81–0.94 for females). Compared with the Quartile (Q)1 group, the HRs (95%CI) of the Q2, Q3 and Q4 groups were 0.84 (0.63–1.03), 0.72 (0.57–0.91) and 0.66 (0.51–0.87) for CVD in males. Females had HRs of 0.79 (0.66–0.96) in Q2, 0.71 (0.57–0.88) in Q3 and 0.58 (0.45–0.75) in Q4 for CVD. The associations between e-CRF and heart disease and stroke were slightly weaker than that for CVD in both males and females.

Conclusions

Higher e-CRF decreases the incident risk of CVD, heart disease and stroke.
A study on the factors influencing the utilization of public health services by China's migrant population based on the Shapley value method
Authors: Suo Zhonghua , Shao Lina , Lang Ying
Published: November 2023

Background

The health of migrants has received significant global attention, and it is a particularly significant concern in China, which has the largest migrant population in the world. Analyzing data on samples from the Chinese population holds practical significance. For instance, one can delve into an in-depth analysis of the factors impacting (1) the health records of residents in distinct regions and (2) the current state of family doctor contracts. This study explores the barriers to access these two health services and the variations in the effects and contribution magnitudes.

Methods

This study involved data from 138,755 individuals, extracted from the 2018 National Migration Population Health and Family Planning Dynamic Monitoring Survey database. The theoretical framework employed was the Anderson health service model. To investigate the features and determinants of basic public health service utilization among the migrant population across different regions of China, including the influence of enabling resources and demand factors, x2 tests and binary logistic regression analyses were conducted. The Shapley value method was employed to assess the extent of influence of each factor.

Results

The utilization of various service types varied among the migrant population, with significant regional disparities. The results of the decomposition of the Shapley value method highlighted variations in the mechanism underlying the influence of propensity characteristics, enabling resources, and demand factors between the two health service types. Propensity characteristics and demand factors were found to be the primary dimensions with the highest explanatory power; among them, health education for chronic disease prevention and treatment was the most influential factor.

Conclusion

To better meet the health needs of the migrant population, regional barriers need to be broken down, and the relevance and effectiveness of publicity and education need to be improved. Additionally, by considering the education level, demographic characteristics, and mobility characteristics of the migrant population, along with the relevant health policies, the migrant population needs to be guided to maintain the health records of residents. They should also be encouraged to sign a contract with a family doctor in a more effective manner to promote the equalization of basic health services for the migrant population.
Diagnosing norms and norm change in rural Bangladesh: an exploration of gendered social norms and women’s empowerment
Authors: Chandramohan Shivani , Salinger Allison P. , Wendt Amanda S. , Waid Jillian L. , Kalam Md. Abul , Delea Maryann G. , Comeau Dawn L. , Sobhan Shafinaz , Gabrysch Sabine , Sinharoy Sheela
Published: November 2023

Background

Gender-transformative public health programs often aim to address power inequities between men and women and promote women’s empowerment. However, to achieve transformative change, it is necessary to first identify the underlying norms that perpetuate these power imbalances. The objective of our study was to use Bicchieri’s theory of social norms and model of norm change to identify gendered norms and evidence of norm change amongst participants of the Food and Agricultural Approaches to Reducing Malnutrition (FAARM) trial in rural Sylhet Division, Bangladesh.

Methods

We conducted ten life history interviews, 16 key informant interviews, and four focus group discussions with women and men in communities within the FAARM study site in rural, north-eastern Bangladesh. We performed a thematic analysis as well as a relational analysis of the data.

Results

We found that social norms dictated the extent and ways in which women participated in household decisions, the locations they could visit, and their autonomy to use household resources. We also found evidence of changes to gendered social norms over time and the desire amongst some men and women to abandon restrictive norms. Certain intersecting factors, such as education and employment, were identified as facilitators and barriers to women’s empowerment and the related gendered expectations.

Conclusions

Our findings corroborate existing norms literature, which highlights the strong role social norms play in influencing women’s empowerment and behaviour. Our study provides an example of rigorous qualitative methodology that others may follow to assess gendered social norms that can be targeted for transformative change.
Exploring the use of masks for protection against the effects of wildfire smoke among people with preexisting respiratory conditions
Authors: Seale Holly , Trent M , Marks G. B. , Shah S , Chughtai A. A. , MacIntyre C. R.
Published: November 2023

Background

The impact of wildfire smoke is a growing public health issue, especially for those living with preexisting respiratory conditions. Understanding perceptions and behaviors relevant to the use of individual protective strategies, and how these affect the adoption of these strategies, is critical for the development of future communication and support interventions. This study focused on the use of masks by people living in the Australian community with asthma or chronic obstructive pulmonary disease (COPD).

Methods

Semi-structured phone interviews were undertaken with people living in the community aged 18 years and over. Participants lived in a bushfire-prone area and reported having been diagnosed with asthma or COPD.

Results

Twenty interviews were undertaken between July and September 2021. We found that, during wildfire episodes, there was an overwhelming reliance on closing windows and staying inside as a means of mitigating exposure to smoke. There was limited use of masks for this purpose. Even among those who had worn a mask, there was little consideration given to the type of mask or respirator used. Reliance on sensory experiences with smoke was a common prompt to adopting an avoidance behavior. Participants lacked confidence in the information available from air-quality apps and websites, however they were receptive to the idea of using masks in the future.

Conclusions

Whilst COVID-19 has changed the nature of community mask use over the last couple of years, there is no guarantee that this event will influence an individual’s mask behavior during other events like bushfires. Instead, we must create social support processes for early and appropriate mask use, including the use of air quality monitoring.
The effect of sodium-glucose co-transporter-2 (SGLT2) inhibitors on blood interleukin-6 concentration: a systematic review and meta-analysis of randomized controlled trials
Authors: Gohari Sepehr , Ismail-Beigi Faramarz , Mahjani Mahsa , Ghobadi Saeed , Jafari Alireza , Ahangar Hassan , Gohari Sheida
Published: November 2023

Background

The low-grade chronic inflammation in diabetes plays an important role in development of cardiovascular and renal complications. Sodium-glucose co-transporter-2 (SGLT2) inhibitors are recognized as protective agents for cardio-renal complications. Interleukin-6 (IL-6) is positively associated with the pathophysiology of metabolic-related pathologies. The aim of this meta-analysis is to investigate the effect of SGLT2 inhibitors on blood IL-6 concentration in randomized controlled trials (RCTs).

Methods

Embase, PubMed, and Scopus were systematically searched up to 1st of November 2023. The eligible studies were RCTs with adult population that had provided blood IL-6 for both control and intervention groups. Cochrane risk-of-bias tool were for study quality assessment. Data were analyzed using random effect model via Stata statistical software.

Results

Eighteen studies with a total of 5311 patients were included. Of which 3222 and 2052 patients were in intervention and control arm, respectively. Of the total population, 49.7% were men. The study durations ranged from 8 to 52 weeks. The pooled analysis showed a significant association between the use of SGLT2 inhibitors and lower IL-6 levels (standardized mean difference (SMD) = -1.04, Confidence Interval (CI): -1.48; -0.60, I2 = 96.93%). Dapagliflozin was observed to have a higher IL-6-lowering effect (SMD = -1.30, CI: -1.89; -0.71, I2 = 92.52) than empagliflozin or canagliflozin. Sub-group analysis of control groups (SMD = -0.58 (-1.01, -0.15) and -1.35 (-2.00, -0.70 for the placebo and active control sub-groups, respectively) and duration of interventions (SMD = -0.78 (-1.28, -0.28) and -1.20 (-1.86, -0.55) for study duration of ≤ 12 and > 12 weeks, respectively) did not change the results. Meta-regression analysis showed a significant correlation between the level of HbA1c and IL-6-lowering efficacy of SGLT2 inhibitors.

Conclusion

IL-6 levels are significantly reduced with the use of SGLT2 inhibitors with HbA1c as the only marker influencing such reductions, and dapagliflozin had the highest potency. The anti-inflammatory effect of SGLT2 inhibitors supports their broader use to address diabetic complications related to inflammatory responses.
The correlation between periodontitis and uncontrolled hypertension is mediated by inflammatory markers: results from a cross-sectional study of urban elderly population in southeast China
Authors: Chen Yue , Zheng Jiaoer , Ni Da , Zhang Denghui , Zhu Haihua
Published: November 2023

Background

Periodontal diseases is considered the most important global oral health burden according to the world health organization (WHO) (Oral health. https://www.who.int/news-room/fact-sheets/detail/oral-health#Overviewth (who.int). Accessed 21 Sep 2023). It is a common local inflammatory disease associated with hypertension, this study aims to explore the relationship between periodontitis and uncontrolled hypertension and whether inflammation indication such as white blood cell (WBC) count or neutrophil count is a mediator of this relationship.

Methods

One thousand four hundred eighty-eight elders attending annual physical and oral examinations in Zhejiang province were included in this study. The staging of Periodontitis was classified as none, mild-moderate and severe. Participants are categorized into two groups based on blood pressure: hypertensive( positive high blood pressure( HBP) history or underwent HBP medication or blood pressure( BP) ≥ 140/90 mmHg) and uncontrolled hypertensive (systolic blood pressure( SBP) ≥ 140 mmHg or distolic blood pressure( DBP) ≥ 90 mmHg). Peripheral blood samples were collected, information on hypertension history and potential confounders (age, sex, smoking, alcohol consumption, exercise frequency, diabetes) was collected in questionnaires. The correlation between periodontitis and hypertension was investigated using logistics regression analyses, mediation analysis was assessed for the effect of inflammation on hypertension.

Results

The study population includes 1,488 participants aged 55–90 years. Odds of uncontrolled hypertension increased significantly along with periodontitis in the regression models both in unadjusted model (odds ratio( OR): 1.407, 95% confidence intervals( CI): 1.037 ~ 1.910) and fully adjusted model (OR: 1.950, 95% CI: 1.127 ~ 3.373). Mediation analysis confirmed that WBC and neutrophic count function as a full mediator of the association between periodontitis and uncontrolled hypertension either in the unadjusted or the adjusted model.

Conclusions

In a study of urban elderly population in southeast China, periodontitis is found to be significantly associated with uncontrolled hypertension, such relation is mediated by WBC and neutrophil count. Periodontitis can increase the difficulty of controlling hypertension. Promotion of periodontal health strategies in the dental setting could help reduce the burden of hypertension and its complications.
Shaoyao decoction alleviates TNBS-induced ulcerative colitis by decreasing inflammation and balancing the homeostasis of Th17/Treg cells
Authors: Wu Dongsheng , Zhang Yu , Zou Bo , Lu Yi , Cao Hui
Published: November 2023

Background

Ulcerative colitis (UC) is a persistent and non-specific inflammatory condition that mainly affects the bowels and has challenging treatment. UC has a growing incidence and significantly affects the well-being of patients. Many medications used to treat UC can disrupt the metabolism and immune system homeostasis, frequently leading to significant adverse effects. Hence, exploring alternative therapies, such as traditional Chinese medicine and probiotics, has recently emerged as a primary research hotspot owing to their safety. Although the therapeutic mechanism of Shaoyao decoction has not been clarified, it has demonstrated a beneficial clinical effect on UC.

Aim

This study aimed to assess the effect of Shaoyao decoction on a rat model of UC and investigate its underlying mechanisms.

Methods

The rat model of UC was induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). The extent of damage to the intestines was assessed using the disease activity index (DAI), colonic mucosa damage index (CMDI), and histological scores. Immunohistochemistry was employed to detect the tissue levels of interleukin (IL)-17, transforming growth factor (TGF)-β1, and IL-10. Additionally, the proportion of Th17 and Treg cells was detected using flow cytometry. In colon tissue, the levels of forkhead box (Fox)p3, RAR-related orphan receptor (ROR)γt, IL-6, p-STAT3, and STAT3 proteins were quantified by Western blotting.

Results

Treatment with Shaoyao decoction enhanced the overall health of rats and reduced colonic damage. Additionally, Shaoyao decoction significantly alleviated the severity of DAI, CMDI, and HS. The proportion of Th17 cells was reduced, and the proportion of Treg cells was increased by Shaoyao decoction. The expression of IL-17 and RORγt was suppressed by Shaoyao decoction, while the expression of IL-10, TGF-β1, and Foxp3 was increased. The expression of IL-6, p-STAT3, and STAT3 was decreased by Shaoyao decoction.

Conclusion

The Shaoyao decoction alleviates the symptoms of TNBS-induced UC by decreasing inflammation and mitigating intestinal damage while preserving the balance between Th17 and Treg. Shaoyao decoction modulates the IL-6/STAT3 axis, thereby regulating the balance between Th17 and Treg cells.
Effect of hand reflexology in ameliorating anxiety, pain, and fatigue among patients undergoing coronary angiography
Authors: Ali Eman Abdeen , Awad Wafaa Hassan Ali , Khedr Mahmoud Abdelwahab , Rabie Emad Abd El Gawad Ali
Published: November 2023

Background

Reflexology is a popular non-invasive complementary medicine technique to enhance anxiety, pain, and fatigue among patients undergoing coronary angiography.

Objective

This study aimed to investigate the effect of hand reflexology in ameliorating anxiety, pain, and fatigue among patients undergoing coronary angiography.

Methods

A quasi-experimental research design was used on 60 patients undergoing coronary angiography at Alexandria Main University Hospital's cardiology department (30 patients in each study and control group). Four tools were used to collect data: the socio-demographic and clinical data assessment sheet, the visual analogue scale, the Rhoten fatigue scale, and the Beck anxiety inventory.

Results

Scores of moderate anxiety, intractable pain, and severe fatigue among the study group significantly decreased after 2 h and three days of applying hand reflexology.

Conclusion

The current study findings showed that hand reflexology is a simple, non-invasive nursing intervention that is effective and useful for managing pain, fatigue, and anxiety in patients undergoing coronary angiography as it resulted in a significant reduction in the severity of pain, fatigue, and anxiety after coronary angiography in the study group compared to the control group.

Trial registration

The study was registered in the clinical trial.gov database (Clinicaltrials.gov NCT05887362, 23/05/2023).
Educational intervention based on health action model to promote safe behavior of hospital service workers
Authors: Mohammadi Maryam , Vahedian-sharoodi Mohammad , Joghatei Zahra , Esmaily Habibullah , Tehrani Hadi
Published: November 2023

Background

Hospitals are considered to be one of the most hazardous environments to work in, and their service workers are exposed to many serious risks. So The purpose of this study was to investigate the effect of educational intervention based on the Health Action Model to promote the safe behavior of hospital service workers.

Methods

In this quasi-experimental study, 45 workers in each of the control and experimental groups participated. Demographic information and data related to Health Action Model constructs were collected through a questionnaire and a checklist, immediately and three months after the intervention. Cronbach’s alpha coefficients were used to confirm the properties of the tools. Educational intervention accompanied was applied in the form of four training classes. The data were analyzed using SPSS 20 software.

Results

Before the intervention, there was no significant difference between the two groups in terms of demographics and the study’s main variables. results showed significant changes in mean scores of safe behavior, Attitude, norms, belief, intention, knowledge in the experimental group three months after the intervention (P < 0.001).

Conclusions

The research results show that Health Action Model educational intervention can change workers’ awareness, attitudes, norms, beliefs, and intentions toward unsafe behavior and improve their safety performance.

Trial registration

IRCTID: IRCT20160619028529N7.
Facilitators and barriers for using outdoor areas in the primary work tasks of eldercare workers in nursing homes
Authors: Jacobsen Sandra Schade , Vilhelmsen Maja , Lottrup Lene , Brandt Mikkel
Published: November 2023

Background

Eldercare workers in nursing homes report high musculoskeletal disorders, stressful work, and sickness absence. Initiatives that can accommodate these issues are needed. Current studies point out that nature contact may offer a range of human health benefits, potentially promoting healthier work among eldercare workers. Therefore, this study aimed to investigate facilitators and barriers for using outdoor areas as part of the daily work among eldercare workers in Danish nursing homes.

Methods

In this multiple case study, we collected data from three nursing homes, conducting three semi-structured focus group interviews with eldercare workers and three individual interviews with nursing home managers. Furthermore, we conducted observations of the daily work and mappings of the nursing homes’ outdoor environments to gain in-depth knowledge of eldercare workers’ and managers’ perspectives on using outdoor areas in their daily work. The data was thematically analysed using ‘The Behaviour Change Wheel’ (BCW), more specifically the COM-B model, as a theoretical foundation for exploring facilitators and barriers for the use of outdoor areas.

Results

Frequently mentioned facilitators were facilities, traditions or repetitive events, positive experiences with residents (‘star moments’), and knowledge about the residents. Frequently mentioned barriers were insufficient staffing, hierarchy in the work tasks, professional identity, and lack of ideas.

Conclusions

The identified facilitators and barriers should be considered when designing initiatives for increased use of outdoor areas or activities of eldercare workers.

Trial registration

According to the Danish ethics committee (Law of committee, (komitéloven) paragraph 14, Sect. 2), qualitative interviews, which do not include human biological materials, do not need neither approval by ethical and scientific committee or informed consent (The Danish National Centre for Ethics).
Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
Authors: Kansal Heena , Chopra Vishal , Garg Kranti , Sharma Siddharth
Published: November 2023

Introduction

Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It has been used to treat dermatitis and inflammation of the digestive tract. In the lungs, Trx has a significant anti-inflammatory impact. On the other hand, Chronic Obstructive Pulmonary Disease (COPD) is one of the significant causes of death in the developed world, with a tremendous individual and socioeconomic impact. Despite new initiatives and endless treatment trials, COPD incidence and death will likely escalate in the coming decades.

Areas covered

COPD is a chronic inflammatory disease impacting the airways, lung parenchyma, and pulmonary vasculature. Oxidative stress and protease-antiprotease imbalances are thought to be involved in the process. The most popular respiratory inflammatory and allergic disorders therapies are corticosteroids and β-receptor agonists. These medications are helpful but have some drawbacks, such as infection and immunosuppression; thus, addressing Trx signalling treatments may be a viable COPD treatment approach. This review shall cover the pathophysiology of COPD, the pharmacognosy of anti-COPD drugs, including the assets and liabilities of each, and the role and mechanism of Trx in COPD treatment.

Expert opinion

Limited research has targeted the thioredoxin system as an anti-COPD drug. Spectating the increase in the mortality rates of COPD, this review article would be an interesting one to research.
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Authors: Zhou Huakang , Khan Dilaware , Hussain Sajid Muhammad , Gerdes Norbert , Hagenbeck Carsten , Rana Majeed , Cornelius Jan Frederick , Muhammad Sajjad
Published: November 2023

Background

Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenotype (SASP). The SASP factors in feed-forward response exacerbate inflammation and cause tissue remodeling, resulting in atherosclerotic plaque formation and rupture.

Results

Colchicine inhibited ROS generation and mitigated oxidative stress-induced DNA damage. It dampened oxidative stress-induced endothelial cell senescence and improved the expression of DNA repair protein KU80 and aging marker Lamin B1. The drug attenuated the expression of senescence marker P21 at mRNA and protein levels. The pathway analysis showed that colchicine inhibited NF-κB and MAPKs pathways and subdued mTOR activation. Colchicine also attenuated mRNA expression of interleukin (IL)-1β, IL-6, IL-8, MCP-1, ICAM-1, and E-selectin. Furthermore, colchicine reduced the mRNA and protein expression of matrix metalloproteinase (MMP-2).

Conclusion

In summary, colchicine blocked oxidative stress-induced senescence and SASP by inhibiting the activation of NF-κB and MAPKs pathways.

Graphical Abstract
Comparative effects of Bowen therapy and tennis ball technique on pain and functional disability in patients with thoracic myofascial pain syndrome
Authors: Amjad Fareeha , Khalid Afsheen
Published: November 2023

Background

Thoracic myofascial pain syndrome is a clinical problem arising from the muscles and soft tissues of thoracic region, which include the mid and upper back area. Risk factors associated with myofascial pain syndrome are muscle overuse and repetitive strain, poor posture, trauma or injury, emotional and psychological stresses. The management of myofascial pain syndrome (MPS) typically involves a multidimensional approach that focuses on relieving pain, reducing muscle tension, and improving muscle function. Bowen therapy and tennis ball technique are also recommended for treating myofascial pain syndrome.

Objective

The objective of this study was to compare the effects of Bowen therapy and tennis ball technique on pain and functional disability in patients with thoracic myofascial pain syndrome.

Methods

It was a randomized clinical trial conducted on thirty patients. It was carried out in physiotherapy outpatient department of D.H.Q Hospital, Kasur. Non-probability convenience sampling technique was used. Data collection was done from the patients of thoracic myofascial pain syndrome by using Numeric Pain Rating Scale (NPRS) for pain and Pain Disability Questionnaire (PDQ) for functional disability. Participants were randomly allocated into two groups using computer generated random number method. Group A received Bowen therapy, and group B received tennis ball technique. Outcome measures were measured at baseline, after second week treatment session and after fourth week with three sessions in a week on alternate days. Data analysis was done by using Statistical Package for the Social Sciences (SPSS) version 26.

Results

There was significant difference between the mean values of NPRS and PDQ in both groups at baseline, second week and fourth week withpvalue < 0.05. The results indicated that both treatments were significant but Bowen therapy is more effective treatment than tennis ball technique. Within-group difference calculated with repeated-measure ANOVA indicated that there was significant difference from pre- to post-values of both groups.

Conclusion

This study concluded that Bowen therapy produced statistically significant and clinically relavant results for all the outcome measures.Trial registration. (IRCT20190717044238N7).
Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients
Authors: Brito Roberto , Morais Caio C. A. , Lazo Marioli T. , Guiñez Dannette V. , Gajardo Abraham I. J. , Arellano Daniel H. , Amato Marcelo B. P. , Cornejo Rodrigo A.
Published: November 2023

Background

In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterogeneous disease, gravity-dependent lung collapse and injurious mechanical ventilation. Computed tomography (CT) is the gold standard for regional strain assessment. An alternative tool could be the electrical impedance tomography (EIT). We aimed to determine whether EIT-based methods can predict the dynamic relative regional strain (DRRS) between two levels of end-expiratory pressure (PEEP) in gravity-non-dependent and dependent lung regions.

Methods

Fourteen ARDS patients underwent CT and EIT acquisitions (at end-inspiratory and end-expiratory) at two levels of PEEP: a low-PEEP based on ARDS-net strategy and a high-PEEP titrated according to EIT. Three EIT-based methods for DRRS were compared to relative CT-based strain: (1) the change of the ratio between EIT ventilation and end-expiratory lung impedance in arbitrary units ([ΔZAU low-PEEP/EELIAU low-PEEP]/[ΔZAU high-PEEP/EELIAU high-PEEP]), (2) the change of ΔZ/EELI ratio calibrated to mL ([ΔZml low-PEEP/EELIml low-PEEP]/[ΔZml high-PEEP/EELIml high-PEEP]) using CT data, and (3) the relative change of ∆ZAU (∆ZAU low-PEEP/∆ZAU high-PEEP). We performed linear regressions analysis and calculated bias and limits of agreement to assess the performance of DRRS by EIT in comparison with CT.

Results

The DRRS assessed by (ΔZml low-PEEP/EELIml low-PEEP)/(ΔZml high-PEEP/EELIml high-PEEP) and ∆ZAU low-PEEP/∆ZAU high-PEEP showed good relationship and agreement with the CT method (R2 of 0.9050 and 0.8679, respectively, in non-dependent region; R2 of 0.8373 and 0.6588, respectively, in dependent region; biases ranging from − 0.11 to 0.51 and limits of agreement ranging from − 0.73 to 1.16 for both methods and lung regions). Conversely, DRRS based on EELIAU ([ΔZAU low-PEEP/EELIAU low-PEEP]/[ΔZAU high-PEEP/EELIAU high-PEEP]) exhibited a weak negative relationship and poor agreement with the CT method for both non-dependent and dependent regions (R2 ~ 0.3; bias of 3.11 and 2.08, and limits of agreement of − 2.13 to 8.34 and from − 1.49 to 5.64, respectively).

Conclusion

Changes in DRRS during a PEEP trial in ARDS patients could be monitored using EIT, based on changes in ΔZmL/EELIml and ∆ZAU. The relative change ∆ZAU offers the advantage of not requiring CT data for calibration.
Simultaneous analysis of the of levamisole with triclabendazole in pharmaceuticals through developing TLC and HPLC–PDA chromatographic techniques and their greenness assessment using GAPI and AGREE methods
Authors: Attia Khalid A. M. , El-Desouky Ebrahim A. , Abdelfatah Amr M. , Abdelshafi Nahla A.
Published: November 2023

Two simple and rapid chromatographic methods were developed and validated for the analysis of levamisole and triclabendazole simultaneously in pure and pharmaceutical products. The first method is thin-layer chromatography (TLC) with densitometry, and the second method is high-performance liquid chromatography with PDA detection (HPLC–PDA). A Hypersil BDS C18 column with dimensions of 4.6 × 150 mm and a particle size of 5 µm was used in the HPLC–PDA method. An isocratic condition was used to carry out the separation, and the mobile phase was made up of acetonitrile and a 0.03 M potassium dihydrogen phosphate buffer in double-distilled water. The ratio of the mobile phase preparation was 70:30 (v/v), and the flow rate was 1 mL/min. A wavelength of 215 nm was employed for analyte detection. Precoated silica gel 60 F254 aluminium plates were used for the TLC method's separation. Mobile phase was made of ethyl acetate, hexane, methanol, and ammonia (69:15:15:1) for the separation. The detection wavelength selected was 215 nm. According to the International Council for Harmonization (ICH) guidelines, the proposed methods were validated and it was found that the two chromatographic methods are accurate, precise, and linear for both compounds in the range of 3.75–37.5 and 6–60 mg/L for the HPLC method for levamisole and triclabendazole, respectively and in the range of 2–14 µg/spot for the TLC method. The developed methods greenness profile was assessed using AGREE and ComplexGAPI tools.

Graphical Abstract
Covariate dependent Markov chains constructed with gradient boost modeling can effectively generate long-term predictions of obesity trends
Authors: Huang Alexander A. , Huang Samuel Y.
Published: November 2023

Importance

The prevalence of obesity among United States adults has increased from 30.5% in 1999 to 41.9% in 2020. However, despite the recognition of long-term weight gain as an important public health issue, there is a paucity of studies studying the long-term weight gain and building models for long-term projection.

Methods

A retrospective, cross-sectional cohort study using the publicly available National Health and Nutrition Examination Survey (NHANES 2017–2020) was conducted in patients who completed the weight questionnaire and had accurate data for both weight at time of survey and weight ten years ago. Multistate gradient boost modeling classifiers were used to generate covariate dependent transition matrices and Markov chains were utilized for multistate modeling.

Results

Of the 6146 patients that met the inclusion criteria, 3024 (49%) of patients were male and 3122 (51%) of patients were female. There were 2252 (37%) White patients, 1257 (20%) Hispanic patients, 1636 (37%) Black patients, and 739 (12%) Asian patients. The average BMI was 30.16 (SD = 7.15), the average weight was 83.67 kilos (SD = 22.04), and the average weight change was a 3.27 kg (SD = 14.97) increase in body weight (Fig. 1). A total of 2411 (39%) patients lost weight, and 3735 (61%) patients gained weight (Table 1). We observed that 87 (1%) of patients were underweight (BMI < 18.5), 2058 (33%) were normal weight (18.5 ≤ BMI < 25), 1376 (22%) were overweight (25 ≤ BMI < 30) and 2625 (43%) were obese (BMI > 30).

From analysis of the transitions between normal/underweight, overweight, and obese, we observed that after 10 years, of the patients who were underweight, 65% stayed underweight, 32% became normal weight, 2% became overweight, and 2% became obese. After 10 years, of the patients who were normal weight, 3% became underweight, 78% stayed normal weight, 17% became overweight, and 2% became obese. Of the patients who were overweight, 71% stayed overweight, 0% became underweight, 14% became normal weight, and 15% became obese. Of the patients who were obese, 84% stayed obese, 0% became underweight, 1% became normal weight, and 14% became overweight.

Conclusions

United States adults are at risk of transitioning from normal weight to becoming overweight or obese. Covariate dependent Markov chains constructed with gradient boost modeling can effectively generate long-term predictions.
Recurrent neural networks for enhanced joint channel estimation and interference cancellation in FBMC and OFDM systems: unveiling the potential for 5G networks
Authors: Al-Makhlasawy Rasha M. , Khairy Mayada , El-Shafai Walid
Published: November 2023

FBMC is a pivotal system in 5G, serving as a cornerstone for efficient use of available bandwidth while simultaneously meeting stringent requirements for high spectral efficiency. Notably, FBMC harnesses the power of multicarrier modulation (MC), a good alternative to orthogonal frequency division multiplexing (OFDM) technology that supports fourth-generation (4G) systems. The wireless communications field is full of challenges, the most important of which are channel estimation and interference cancellation, both of which deserve comprehensive study to increase the efficiency of data transmission. In this paper, our investigation takes a deliberate step towards the convergence of two prominent modulation models: OFDM and FBMC. We specifically contrast these modulation techniques with the intricate field of joint channel estimation and interference cancellation (JCEIC). In this research study, we take advantage of recurrent neural networks' (RNNs') efficiency as a vehicular channel to perform precise channel estimation and recovery of uncorrupted transmitted signals, thereby lowering the bit error rate (BER). Our channel estimation for a dual selective channel is based on the thoughtful placement of pilots scattered over the temporal and frequency dimensions, and is further improved by the interference cancellation method of low complexity that was selected. Our JCEIC proposal aims to integrate RNNs carefully, using the output sequences of JCEIC algorithms as useful inputs to this neural architecture. By clearly demonstrating a decrease in BER as compared to traditional approaches, it is evident that the performance of the novel approach is near to that of a perfect channel. Additionally, a comparison of the performance of FBMC and OFDM systems at various signal-to-noise ratios reveals a clear performance divide that favors the former in terms of system efficiency. The BER is restricted by FBMC to a commendable threshold of less than 0.1 at a modest 5 dB, continuing the higher trend started by its improved RNN-based channel estimate. The accuracy of channel estimation is clearly improved by this paradigm shift, and the computing complexity typical of 5G networks is also clearly reduced.