bluuebunny/crossref_metadata_2025 huggingface dataset:
Memoria colectiva, tradición y costumbre. A los 100 años de la reseña de Marc Bloch a Maurice Halbwachs
Authors:   Universidad de Salamanca, Dacosta Martínez Arsenio Fernando
Published: February 2025

Marc Bloch reseñó en 1925 Les cadres sociaux de la mémoire de Maurice Halbwachs, señalando su contribución a la comprensión de la memoria colectiva, pero también sus limitaciones conceptuales y metodológicas. Cuestionó el carácter esencialista del término, advirtiendo el riesgo de un antropomorfismo impreciso y de una memoria social entendida de forma demasiado abstracta. Destacó la importancia de la comunicación y la transmisión intergeneracional, aspectos que Halbwachs no desarrolló suficientemente. Criticó la ausencia de un análisis de la memoria jurídica y de la costumbre, fundamentales para entender las estructuras sociales en el tiempo. Su lectura de la memoria como fenómeno social y dialéctico anticipó debates posteriores sobre la diversidad de memorias colectivas.
Effect of scanning speed on the organization and properties of CoCrFeNi fusion cladding layer
Authors: Zhu Weiqian , Wang Shanchen , Zhao Zitian , Li Yunlong , Li Xiaofeng , Wang Jianhong
Published: February 2025

The effects of the scanning speed on the organization, hardness, and corrosion properties of laser-melted CoCrFeNi-fused cladding layers were investigated. In this paper, a CoCrFeNi high-entropy alloy cladding layer was prepared on the surface of the CX stainless steel substrate using laser cladding technology. The physical phase, microstructure, hardness, and corrosion resistance of the cladding layer were analyzed by an x-ray diffractometer, a scanning electron microscope, an energy dispersive spectrometer (EDS), a microhardness tester, and an electrochemical workstation. The effects of scanning speed on the organization and corrosion resistance of the cladding were further investigated. The results showed that good metallurgical bonding between the coating and the substrate was achieved at different laser scanning speeds, and no obvious defects were observed in the fused cladding layer, which was organized by columnar crystals and equiaxial crystals. The phase composition of the molten cladding layer did not change with the increase in scanning speed, and all of them were face-centered-cubic. With the increase in the scanning speed, the hardness of the fused cladding layer shows a trend of increasing and then decreasing; when the scanning speed is 6 mm/s, the hardness of the fused cladding layer is the largest, 203.1 HV 0.2, and at this time, the corrosion resistance of the fused cladding layer reaches the optimum, and the self-corrosion current density is the smallest, 3.6 × 10−8 A/cm2. When the laser power is set to 1400 W and the scanning speed is 6 mm/s, the corrosion performance of the fused cladding layer is better than that of the stainless steel substrate.
Establishment and characterization of persistent
Pseudomonas aeruginosa
infections in air–liquid interface cultures of human airway epithelial cells
Authors: Bouheraoua Safaa , Cleeves Sven , Preusse Matthias , Müsken Mathias , Braubach Peter , Fuchs Maximilian , Falk Christine , Sewald Katherina , Häussler Susanne
Published: February 2025

Bacteria exhibit distinct behaviors in laboratory settings compared to infection environments. The presence of host cells induces changes in bacterial activity, while pathogens trigger immune responses that shape the microenvironment. Studying infection dynamics by microscopy, cytokine screening, and dual RNA sequencing in an air–liquid interface model, we found that prolonged
Pseudomonas aeruginosa
colonization of airway epithelium led to a pro-inflammatory response, consistent across
P. aeruginosa
strains, despite differences in the dynamics of this response. Concurrently,
P. aeruginosa
formed non-attached aggregates on the apical side of the cell layer and upregulated genes involved in biofilm formation and virulence. Notably, there was remarkable resemblance between the
P. aeruginosa
transcriptional profile in our model and that previously reported upon host cell contact. Developing a platform that replicates host microenvironments is vital not only for gaining deeper insights into the interplay between host and pathogen but also for evaluating therapeutic strategies in conditions that closely mirror clinical environments.
Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in
Aspergillus fumigatus
Authors: Seo Hye-won , Bok Jin Woo , Keller Nancy P.
Published: February 2025

The field of secondary metabolism has greatly benefitted from computational advances in recent years. This has been particularly true for fungal natural product studies. Strides in genome mining have led to the identification of an extraordinary number of secondary metabolite biosynthetic gene clusters (BGCs) across the fungal Kingdom and metabologenomic platforms can group BGCs into gene cluster families and link them to initial chemical structures. Missing are computational applications focused on identifying BGC regulatory networks. Here, we applied the new online gene regulatory network resource, GRAsp (
G
ene
R
egulation of

Asp
ergillus fumigatus

), to identify unknown and unpredictable BGC trans-acting transcriptional/metabolite production modules. GRAsp correctly predicted a two-component regulatory module composed of the transcription factors (TFs), RogA (
r
egulation
o
f
g
liotoxin) and HsfA, which negatively regulate the gliotoxin BGC and are also involved in gliotoxin self-protection. RogA functions through the repression of
gliZ,
the pathway-specific gliotoxin TF, and HsfA functions by activating
rogA
expression. Furthermore, GRAsp identified TFs that regulate the production of two BGCs lacking pathway-specific TFs, the helvolic acid and fumitremorgin BGCs, respectively. Finally, the known TF, NsdD, was predicted and found to regulate the hexadehydroastechrome BGC. These advances highlight the power of inference algorithms to uncover unpredictable networks in specialized metabolite synthesis.

IMPORTANCE

Toxic secondary metabolites are virulence factors of the opportunistic fungal pathogen
Aspergillus fumigatus,
yet the transcriptional networks regulating secondary metabolite production remain elusive. Uncovering novel regulators without any prior information is challenging. Computational programs have gained prominence in the field of secondary metabolite research due to their accuracy and ability to handle vast amounts of data, including DNA, RNA, and protein data. In this study, a newly developed online computer platform, Gene Regulation of
A. fumigatus
, was used to identify five regulators involved in the production of several
A. fumigatus
toxins, including gliotoxin, helvolic acid, fumitremorgin, and hexadehydroastechrome. This work illustrates the potential for discovering new trans-acting regulators and mechanisms of secondary metabolite regulation through the examination of computational gene regulatory networks.
Rapid and sensitive isolation of
Campylobacter jejuni
using immunomagnetic separation from patient specimens exposed to oxygen
Authors: Kim So Yeon , Yun Young-Sun , Lee Kwang-Jun , Kim Jonghyun
Published: February 2025

This study describes a method for detecting
Campylobacter jejuni
in patient stools with subsequent isolation using antibody–magnetic beads in conjunction with selective culture and PCR. Monoclonal antibodies specific for the flagellin A and major outer membrane protein of
C. jejuni
were generated; two clones (1C7 and 4B2) were used to coat magnetic beads for immunomagnetic separation (IMS).
C. jejuni
strain NCTC11168 was recovered from human stool samples spiked with varying concentrations (10
1
–10
5
CFU/mL) by
Campylobacter
(Campy)-IMS or a conventional culture-based method and plated on modified charcoal–cefoperazone–deoxycholate agar; the number of colonies was enumerated. The detection limits of Campy-IMS and conventional culture-based method with spiked stool samples were 10
2
and 10
4
CFU/mL, respectively. The sensitivity of IMS-PCR was 10–10,000-fold higher than that of direct PCR. The recovery rate of
C. jejuni
from spiked stools stored for 12 to 72 h decreased from 72.3 to 5.9% with Campy-IMS and from 48.5 to 0.1% with the conventional culture-based method. Importantly, of 20 PCR (+)/bacterial culture (−) samples that were diagnosed as probable cases according to general criteria, 95% (19/20) were confirmed positive by Campy-IMS. Thus, this study suggests a solution to overcome the problems caused by the inconsistency between probable and confirmed cases of
Campylobacter
infection.

IMPORTANCE

The isolation, cultivation, and maintenance of
Campylobacter
spp. are difficult because of the microaerophilic conditions and specific medium needed. Although selective media are useful for the initial isolation of
Campylobacter
, subsequent exposure of the sample to oxygen has a detrimental effect on the positive culture rate of
Campylobacter
, significantly lowering the isolation rate from patient samples. In this study, the detection limit was improved by combining immunomagnetic separation and PCR methods to quickly detect
Campylobacter jejuni
in clinical patient stool samples using antibody
–
magnetic beads. Therefore, this study is expected to improve confirmation of
C. jejuni
infection where diagnosis would previously fail with patient samples because of oxygen exposure, inappropriate diagnostic methods, and interference from other bacteria in the sample.
Integrated Teaching Evaluation of Physical Education in Colleges and Universities Based on Multi-class Support Vector Machine
Authors: Dai Guang-Song
Published: February 2025

Classroom teaching in higher education institutions serves as the primary instructional approach, forming the bedrock of academic guidance. Its pivotal role underscores the need for an effective evaluation system to assess classroom teaching quality. This system not only contributes significantly to the theoretical advancement of higher education teaching but also ensures the seamless execution of quality assessments, playing a crucial role in enhancing educational activities. This study proposes a teaching quality evaluation model based on Support Vector Machine (SVM), leveraging SVMs ability to handle small sample data effectively. The model aligns with the Ministry of Education’s evaluation system and enhances objectivity in processing evaluation data through SVMs multi-classification capabilities in the web system of the teaching guarantee system. The paper analyzes the significance of evaluating classroom teaching quality and identifies shortcomings in traditional evaluation methods. A comprehensive evaluation index system for classroom teaching quality is formulated, considering specific needs and construction principles. Recognizing nonlinear relationships among indicators, the study applies the SVM algorithm to address potential challenges in teaching quality evaluation. Grounded in practical and economic considerations, as well as the author’s professional experience, the paper integrates data mining technology and SVM theory to establish a suitable classification method for teaching quality evaluation in higher education institutions.
Risk Factors Associated with Collapse of Distal Radius Fractures after Volar Locking Plate Fixation in Older Adults
Authors: LEE Sanglim , JEON Suk Ha
Published: February 2025

Background: This study aimed to identify the risk factors associated with re-displacement or collapse of distal radius fractures treated using volar locking plates in older adults.

Methods: We conducted a retrospective analysis of 131 patients aged ≥65 years with distal radius fractures who underwent volar locking plate fixation. The collapse was classified into three categories: ‘radial collapse’ was determined as the top decile of patients with the greatest decrease in radial inclination; ‘dorsal collapse’ was defined by volar tilt angle on lateral or 25° tilted lateral views and ‘height collapse’ by radial height. To identify the factors related to these three types of collapses, we compared the clinical and radiological parameters between the wrists with each type of collapsed and non-collapsed wrists.

Results: Dorsal collapse had no significant associated factors and radial collapse had osteoporosis as a significant different factor. The height collapse group was associated with older age, had a higher prevalence of high-energy injury mechanisms and a limited range of flexion–extension at final follow-up and larger distance between the articular surface and distal screws.

Conclusions: The volar locking plate may effectively prevent three types of collapses. Height collapse group included patients with increased age, high-energy injury mechanisms and limited range of flexion–extension at the time of final follow-up. To prevent collapse, the longest possible distal screws must be inserted just beneath the subchondral bone.

Level of Evidence: Level IV (Therapeutic)
Sensory Nerve Transfer for Intractable Neuropathic Pain in a Case of C8-T1 Root Avulsion in Brachial Plexus Injury
Authors: MAURYA Sanjay , BENIWAL Shivam , SINGH Onkar
Published: February 2025

Neuropathic pain in root avulsion brachial plexus injury (BPI) is severe and unrelenting. Routine analgesics and other described methods often provide inadequate pain relief. We report a patient with neuropathic pain following C8T1 root avulsion injury, which was successfully managed with end-to-side ulnar sensory branch transfer to the median nerve. Postoperatively, there was a marked reduction in pain score as determined by visual analogue score (VAS) and a marked improvement in the daily sleep interference scale (DSIS). This option may be considered in patients with severe neuropathic pain in lower root avulsion injury in BPI.

Level of Evidence: Level V (Therapeutic)
Efficient Isogeometric Analysis-Based Modeling for Transmit-Receive Mode: Application to Both Circular and Parallel-Faced Planar Transducer and Hard Reflector
Authors: Alia Ahlem
Published: February 2025

To avoid computing a double integral when simulating the acoustic field diffracted by a finite-sized hard reflector, its surface is discretized into many elements, and then each element is treated as a point-like reflector. The total acoustic field diffracted by the finite-sized hard reflector is calculated by adding the acoustic fields diffracted by each element. The efficiency of this approach over numerically computing the double integral boundary equation has been shown within an isogeometric analysis framework.
DFlows
:
A Flow-based Programming
Approach for a Polyglot Design-Space Exploration Framework
Authors: Peverelli Francesco , Paletti Daniele , Conficconi Davide
Published: February 2025

Current architectural Design-Space Exploration (DSE) tools specify the exploration problem through annotations or pragmas. However, this approach is inherently language-dependent and limits the applicability to one specific target language and synthesis toolchain. Additionally, the rapid development of new hardware Domain-Specific Languages, programming models, and different exploration heuristics calls for a language-agnostic and modular approach. To address this need, we present a DSE formalization to facilitate the integration of new components and customized flows and leverage it to implement
DFlows
, a
flow-based-programming
DSE tool that decouples problem definition, code generation, exploration, and evaluation strategies.
DFlows’s
compiler-based frontend provides language-agnostic generation of design points through Abstract Syntax Tree manipulation. We show how DFlows can integrate custom performance models from complex state-of-the-art accelerators for Verilog, VHDL, Chisel, and HLS designs. We compare the runtimes of our DSE process against a state-of-the-art Chisel-based DSE tool, achieving up to 3.74× speedup while identifying the same set of optimal solutions. Additionally, we integrate in
DFlows
a custom exploration heuristic leveraging genetic algorithms and a novel online learning fitness function approximation methodology. This approximation yields a negligible hypervolume difference with the exhaustive search Pareto-front while improving DSE runtime by up to 2.67×.
Ionospheric TEC Forecast Using Bi‐LSTM With the Adam Optimizer During X‐Class Solar Flares Occurred in the Year 2024 and Validation With IRI‐2020
Authors: Dass Sarat C. , Muthu T. , Mukesh R. , Raghavi B. , Muthamil S. , Nivetha S. , Kiruthiga S.
Published: February 2025

Satellite communication and navigation systems have become more essential to everyday life, but at the same time, understanding the effect of solar activity on these systems is vital. Total electron content (TEC) is a key factor affecting satellite signals. Solar flares affect the TEC variations, and this research examines the forecast of TEC during various X‐class solar flares that occurred in February, March, May, June, July, and August 2024, employing a bidirectional long short‐term memory (Bi‐LSTM) coupled with the Adam optimizer (Bi‐LSTM‐AO). The forecasted results were validated with the IRI‐2020. This study uses a robust dataset encompassing more than 1 year of TEC data from the IONOLAB database, along with key solar and geomagnetic parameters such as Kp, Ap, SSN, and F10.7 obtained from NASA OMNIWeb. These potent solar flares were scrutinized to evaluate the model’s performance in forecasting TEC variations under extreme solar activity. The Bi‐LSTM‐AO model exhibited exceptional accuracy in predicting TEC values across these dates, consistently outperforming the IRI‐2020 model. For example, on May 14, 2024, coinciding with the X8.79 solar flare, the Bi‐LSTM‐AO model achieved impressive performance metrics, including a root‐mean‐square error of 3.52, a mean absolute percentage error of 6.88%, a mean absolute gross error of 2.97, and a centered mean square deviation of 9.93. In contrast, the IRI‐2020 model showed significantly higher error metrics, with an RMSE of 13.18, a MAPE of 23.61%, and a MAGE of 10.93. This research provides the development of a more accurate space weather forecasting model to increase the positional accuracy in navigation systems. The improved predictions can enhance the reliability of satellite‐dependent systems, which are increasingly important for global communication and navigation systems.
Table S5 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
Authors: Venneti Sriram , Kawakibi Abed Rahman , Ji Sunjong , Waszak Sebastian M. , Sweha Stefan R. , Mota Mateus , Pun Matthew , Deogharkar Akash , Chung Chan , Tarapore Rohinton S. , Ramage Samuel , Chi Andrew , Wen Patrick Y. , Arrillaga-Romany Isabel , Batchelor Tracy T. , Butowski Nicholas A. , Sumrall Ashley , Shonka Nicole , Harrison Rebecca A. , de Groot John , Mehta Minesh , Hall Matthew D. , Daghistani Doured , Cloughesy Timothy F. , Ellingson Benjamin M. , Beccaria Kevin , Varlet Pascale , Kim Michelle M. , Umemura Yoshie , Garton Hugh , Franson Andrea , Schwartz Jonathan , Jain Rajan , Kachman Maureen , Baum Heidi , Burant Charles F. , Mottl Sophie L. , Cartaxo Rodrigo T. , John Vishal , Messinger Dana , Qin Tingting , Peterson Erik , Sajjakulnukit Peter , Ravi Karthik , Waugh Alyssa , Walling Dustin , Ding Yujie , Xia Ziyun , Schwendeman Anna , Hawes Debra , Yang Fusheng , Judkins Alexander R. , Wahl Daniel , Lyssiotis Costas A. , de la Nava Daniel , Alonso Marta M. , Eze Augustine , Spitzer Jasper , Schmidt Susanne V. , Duchatel Ryan J. , Dun Matthew D. , Cain Jason E. , Jiang Li , Stopka Sylwia A. , Baquer Gerard , Regan Michael S. , Filbin Mariella G. , Agar Nathalie Y.R. , Zhao Lili , Kumar-Sinha Chandan , Mody Rajen , Chinnaiyan Arul , Kurokawa Ryo , Pratt Drew , Yadav Viveka N. , Grill Jacques , Kline Cassie , Mueller Sabine , Resnick Adam , Nazarian Javad , Allen Joshua E. , Odia Yazmin , Gardner Sharon L. , Koschmann Carl
Published: February 2025

VST-transformed gene expression values for all samples and protein-coding genes.
Table S3 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
Authors: Venneti Sriram , Kawakibi Abed Rahman , Ji Sunjong , Waszak Sebastian M. , Sweha Stefan R. , Mota Mateus , Pun Matthew , Deogharkar Akash , Chung Chan , Tarapore Rohinton S. , Ramage Samuel , Chi Andrew , Wen Patrick Y. , Arrillaga-Romany Isabel , Batchelor Tracy T. , Butowski Nicholas A. , Sumrall Ashley , Shonka Nicole , Harrison Rebecca A. , de Groot John , Mehta Minesh , Hall Matthew D. , Daghistani Doured , Cloughesy Timothy F. , Ellingson Benjamin M. , Beccaria Kevin , Varlet Pascale , Kim Michelle M. , Umemura Yoshie , Garton Hugh , Franson Andrea , Schwartz Jonathan , Jain Rajan , Kachman Maureen , Baum Heidi , Burant Charles F. , Mottl Sophie L. , Cartaxo Rodrigo T. , John Vishal , Messinger Dana , Qin Tingting , Peterson Erik , Sajjakulnukit Peter , Ravi Karthik , Waugh Alyssa , Walling Dustin , Ding Yujie , Xia Ziyun , Schwendeman Anna , Hawes Debra , Yang Fusheng , Judkins Alexander R. , Wahl Daniel , Lyssiotis Costas A. , de la Nava Daniel , Alonso Marta M. , Eze Augustine , Spitzer Jasper , Schmidt Susanne V. , Duchatel Ryan J. , Dun Matthew D. , Cain Jason E. , Jiang Li , Stopka Sylwia A. , Baquer Gerard , Regan Michael S. , Filbin Mariella G. , Agar Nathalie Y.R. , Zhao Lili , Kumar-Sinha Chandan , Mody Rajen , Chinnaiyan Arul , Kurokawa Ryo , Pratt Drew , Yadav Viveka N. , Grill Jacques , Kline Cassie , Mueller Sabine , Resnick Adam , Nazarian Javad , Allen Joshua E. , Odia Yazmin , Gardner Sharon L. , Koschmann Carl
Published: February 2025

Individual cases from historical control datasets.
Table S13 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
Authors: Venneti Sriram , Kawakibi Abed Rahman , Ji Sunjong , Waszak Sebastian M. , Sweha Stefan R. , Mota Mateus , Pun Matthew , Deogharkar Akash , Chung Chan , Tarapore Rohinton S. , Ramage Samuel , Chi Andrew , Wen Patrick Y. , Arrillaga-Romany Isabel , Batchelor Tracy T. , Butowski Nicholas A. , Sumrall Ashley , Shonka Nicole , Harrison Rebecca A. , de Groot John , Mehta Minesh , Hall Matthew D. , Daghistani Doured , Cloughesy Timothy F. , Ellingson Benjamin M. , Beccaria Kevin , Varlet Pascale , Kim Michelle M. , Umemura Yoshie , Garton Hugh , Franson Andrea , Schwartz Jonathan , Jain Rajan , Kachman Maureen , Baum Heidi , Burant Charles F. , Mottl Sophie L. , Cartaxo Rodrigo T. , John Vishal , Messinger Dana , Qin Tingting , Peterson Erik , Sajjakulnukit Peter , Ravi Karthik , Waugh Alyssa , Walling Dustin , Ding Yujie , Xia Ziyun , Schwendeman Anna , Hawes Debra , Yang Fusheng , Judkins Alexander R. , Wahl Daniel , Lyssiotis Costas A. , de la Nava Daniel , Alonso Marta M. , Eze Augustine , Spitzer Jasper , Schmidt Susanne V. , Duchatel Ryan J. , Dun Matthew D. , Cain Jason E. , Jiang Li , Stopka Sylwia A. , Baquer Gerard , Regan Michael S. , Filbin Mariella G. , Agar Nathalie Y.R. , Zhao Lili , Kumar-Sinha Chandan , Mody Rajen , Chinnaiyan Arul , Kurokawa Ryo , Pratt Drew , Yadav Viveka N. , Grill Jacques , Kline Cassie , Mueller Sabine , Resnick Adam , Nazarian Javad , Allen Joshua E. , Odia Yazmin , Gardner Sharon L. , Koschmann Carl
Published: February 2025

GSEA analysis of genes with significantly lower chromatin accessibility at promoters and enhancers and reduced gene expression in DIPG007 cells treated with ONC201 versus vehicle.
Table S10 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
Authors: Venneti Sriram , Kawakibi Abed Rahman , Ji Sunjong , Waszak Sebastian M. , Sweha Stefan R. , Mota Mateus , Pun Matthew , Deogharkar Akash , Chung Chan , Tarapore Rohinton S. , Ramage Samuel , Chi Andrew , Wen Patrick Y. , Arrillaga-Romany Isabel , Batchelor Tracy T. , Butowski Nicholas A. , Sumrall Ashley , Shonka Nicole , Harrison Rebecca A. , de Groot John , Mehta Minesh , Hall Matthew D. , Daghistani Doured , Cloughesy Timothy F. , Ellingson Benjamin M. , Beccaria Kevin , Varlet Pascale , Kim Michelle M. , Umemura Yoshie , Garton Hugh , Franson Andrea , Schwartz Jonathan , Jain Rajan , Kachman Maureen , Baum Heidi , Burant Charles F. , Mottl Sophie L. , Cartaxo Rodrigo T. , John Vishal , Messinger Dana , Qin Tingting , Peterson Erik , Sajjakulnukit Peter , Ravi Karthik , Waugh Alyssa , Walling Dustin , Ding Yujie , Xia Ziyun , Schwendeman Anna , Hawes Debra , Yang Fusheng , Judkins Alexander R. , Wahl Daniel , Lyssiotis Costas A. , de la Nava Daniel , Alonso Marta M. , Eze Augustine , Spitzer Jasper , Schmidt Susanne V. , Duchatel Ryan J. , Dun Matthew D. , Cain Jason E. , Jiang Li , Stopka Sylwia A. , Baquer Gerard , Regan Michael S. , Filbin Mariella G. , Agar Nathalie Y.R. , Zhao Lili , Kumar-Sinha Chandan , Mody Rajen , Chinnaiyan Arul , Kurokawa Ryo , Pratt Drew , Yadav Viveka N. , Grill Jacques , Kline Cassie , Mueller Sabine , Resnick Adam , Nazarian Javad , Allen Joshua E. , Odia Yazmin , Gardner Sharon L. , Koschmann Carl
Published: February 2025

Upregulated and downregulated metabolites in DIPG007 cells treated with ONC201 versus vehicle.
Pan-cancer analysis of oncogenic MET fusions reveals distinct pathogenomic subsets with differential sensitivity to MET-targeted therapy
Authors: Febres-Aldana Christopher A. , Vojnic Morana , Odintsov Igor , Zhang Tom , Cheng Ryan , Beach Catherine Z. , Lu Daniel , Mattar Marissa S. , Gazzo Andrea M. , Gili Leo , Harshan Manju , Ameri Ali , Machnicki Stephen , Xiao Xiuying , Lockwood William W. , Zhou Xiao-yan , Yao Qianlan , Drilon Alexander , Rekhtman Natasha , Shah Nameeta , Li Anqi , Liu Zebing , Yang Soo-Ryum , Davare Monika A. , Ladanyi Marc , Somwar Romel
Published: February 2025

MET fusions (MET-Fs) are oncogenic drivers that remain poorly characterized. Analysis of 56 MET-F-positive tumors from an institutional cohort of 91,119 patients (79,864 DNA-seq plus 11,255 RNA-seq) uncovered two forms of MET-F pathobiology. The first group featured 5’ partners with homodimerization domains fused in-frame with MET-tyrosine kinase domain (TKD), primarily originated from translocations, frequently excluded MET exon 14, mediated oncogenesis through cytoplasmic aggregation and constitutive activation, and were markedly sensitive to MET tyrosine kinase inhibitors (TKI) in pre-clinical models and patients with lung cancer. The second group lacked partner homodimerization motifs and retained MET transmembrane and extracellular domains. Their pathogenesis involved intrachromosomal rearrangements, resulting in partner selection for promoter hijacking and fusion allele amplification. Membrane-bound fusions were enriched in gliomas with RTK co-alterations. We provide a framework to comprehend the heterogeneous landscape of MET-Fs, supporting that fusion oncogenicity and MET-TKI sensitivity are determined by structural topology and pathogenomic context.
Avaliação da composição corporal e da ingestão alimentar de nadadores com deficiência
Authors: Cipriano Geisiane Martins , Alipio Filho Alexandre , Andrade Felipe Kaluf de , Silva Amanda Santos , Franco Gabriel Silveira , Manochio-Pina Marina Garcia
Published: February 2025

This study had the purpose to evaluate the body composition and dietary intake of disabled swimmers in a city in the interior of the state of São Paulo. Ten individuals participated in the study, five of each sex, who trained at a university gymnasium and agreed to take part in the survey by taking part in an interview about their eating habits. An anthropometric assessment (weight and height) was performed, body composition (skin folds) and food intake (three 24-hour recalls) that was calculated by the Diet Pro 5i software. Regarding body composition, body mass index and mean fat percentage was 24,84 ± 5,10 kg/m² and 17,8 ± 5,76 % for men, 28,1 ± 4,32 kg/m² and 26,75 ± 6,08 % for women. Regarding food intake, the caloric value and the calcium and iron minerals were below the daily recommendations, while vitamin C and sodium presented adequate values. The food and nutritional characterization of this population is of great importance, as it enables better understanding of your needs and assists the development of nutritional interventions with the purpose of improving the quality of life and sports performance.
Evidências de validade baseada nas relações com medidas externas e confiabilidade do IFIS - BRA
Authors: Sobral Hildeberto Dutra , Correia Júnior Jânio Luiz , Pereira Débora de Almeida , Gonçalves Marina Pereira , Santos Hamilton Felipe Andrade , Carvas Junior Nelson , Dias Ricardo de Freitas
Published: February 2025

A avaliação do nível da aptidão física em adolescentes apresenta-se como preditor de doenças crônicas degenerativas da fase adulta, logo a sua mensuração por meio simples, barato e de fácil aplicabilidade faz com que o International Fitness Scale, seja de interesse da saúde pública mundial. Portanto, nosso objetivo foi avaliar as evidências baseadas nas relações com variáveis externas e confiabilidade do International Fitness Scale - versão brasileira (IFIS - BRA). Participaram do estudo adolescentes, de ambos os sexos. Foram aplicados o IFIS - BRA e testes físicos nos adolescentes. Tomados em conjunto os resultados, podemos afirmar que o IFIS - BRA, oferece indicadores psicométricos satisfatórios.
Guideline-Directed Medical Therapy for Heart Failure in Transthyretin Amyloid Cardiomyopathy
Authors: Schwarting Stéphanie Kristina , Bieber Thomas , Davies Daniel R. , aus dem Siepen Fabian , Schwarting Julian , Grabmaier Ulrich , Massberg Steffen , Maurer Mathew S. , Kääb Stefan
Published: February 2025

Cardiac amyloidosis is an underdiagnosed cause of infiltrative cardiomyopathy, leading to heart failure across the spectrum of ejection fractions. Although there are approved disease-modulating therapies for the transthyretin subtype (transthyretin amyloid cardiomyopathy [ATTR-CM]), the role of heart failure medications remains uncertain and challenging in clinical practice. Their effects on clinical outcomes, such as mortality and hospitalization, are unknown for ATTR-CM. This review aims to explore the use of these medications in ATTR-CM, considering the disease’s stage and patient-specific issues, such as fluid homeostasis, autonomic dysfunction, conduction disorders, low and fixed stroke volumes, and decreased functional capacity. As our understanding of this condition deepens, it is important to reassess the impact of contemporary heart failure medication in ATTR-CM. Finally, the relevance of guideline recommendations for heart failure drugs based on left ventricular ejection fraction should be reconsidered in the context of ATTR-CM.
Interplay Between Social Vulnerability Index and Coronary Artery Calcium Scores With Major Adverse Cardiovascular Events
Authors: Albar Zainab , Salerno Pedro R.V.O , Tashtish Nour , Sirasapalli Santosh K. , Li Shuo , Nasir Khurram , Deo Salil , Rajagopalan Sanjay , Al-Kindi Sadeer
Published: February 2025

BACKGROUND:

Coronary artery calcium (CAC) scoring predicts cardiovascular risk, but social determinants of health may play a role in its prognostic ability. We examined whether the Social Vulnerability Index (SVI) modifies the association between CAC and major adverse cardiovascular events (MACE) in a community-based screening cohort.

METHODS:

We studied 49 224 participants without known cardiovascular disease referred for CAC scanning from 2014 to 2022 based on cardiovascular risk factors. SVI was determined for each participant based on the census tract. We examined 8-year incidence of MACE (myocardial infarction, stroke, heart failure, revascularization, death) by SVI quartile across CAC score strata (0, 1–99, 100–399, ≥400). Cox proportional hazard models estimated hazard ratios for MACE, associated with demographics, metabolic factors, and CAC.

RESULTS:

Higher SVI was associated with female sex, non-White race, greater comorbidities, and higher CAC scores. The 8-year MACE rate increased monotonically by SVI quartile, with a hazard ratio of 1.54 (95% CI, 1.24–1.90,
P
<0.001) for the highest versus lowest SVI quartile after adjustment. The association between CAC score and MACE was modified by SVI, with a stronger gradient in risk across CAC strata apparent among vulnerable subgroups.

CONCLUSIONS:

In this no-cost community-based CAC cohort, SVI independently predicted adverse cardiovascular outcomes across all CAC strata. Focused efforts to mitigate the incremental risk associated with social vulnerability are needed.
On-Site in the City: Comparative Urban Aesthetics in Asia at the turn of the 21st Century
Authors: Lin Nancy P. , Dadi Iftikhar
Published: February 2025

Compelled by dramatic urban transformations in cities across Asia that have been ongoing since the late 20th and into the 21st century, artists in this region have engaged the built environment in innovative new ways. These artists move beyond simply depicting the city in earlier photojournalist, documentary, and modernist approaches to incorporate the effects of the specific sites they investigate into their modes and processes, and often even in their artistic materials. Emerging from local and interregional contexts within Asia, these creative approaches are in dialog with Western urban aesthetic forms and traditions yet also depart from them by incorporating fragments and palimpsests from their own fraught historical formation. This special issue, On-Site in the City: Comparative Urban Aesthetics in Asia at the turn of the 21st Century, brings urban artistic practices across Asia into a comparative register, highlighting artists and works from regions in South, Southeast, and East Asia, many of which include underrepresented and marginal spaces and “minor” subjectivities. Together, they illuminate a range of new aesthetic modes—from the calligraphic to the photographic, from the spectral to the speculative—that reflect 21st century urban life within postindustrial, postsocialist, and postcolonial conditions.
Back to the Site: Documentary as I Understand It
Authors: Wenguang Wu
Published: February 2025

Wu Wenguang's article ‘Back to the Site: Documentary as I Understand It’ is one of the first attempts to theorize the Chinese concept of xianchang, or working on site. A location-based practice common to filmmakers and experimental artists, xianchang evolved in 1990s China both as a reaction against Socialist Realist aesthetics, and as an attempt to recuperate their socially engaged potential. This introduction explores Wu's understanding of the distinct spatial, temporal, and everyday qualities of xianchang, while locating the emergence of on-site practices in relation to the period's rapid socio-economic changes, particularly the challenges and opportunities presented by large-scale urbanization.
How Do Infants Experience Caregiving?
Authors: Thomas Ashley J. , Steele Christina M. , Gopnik Alison , Saxe Rebecca R.
Published: February 2025

Almost all of human infants’ experience and learning takes place in the context of caregiving relationships. This essay considers how infants understand the care they receive. We begin by outlining plausible features of an “intuitive theory” of care. In this intuitive theory, caregiving has both a distinctive foundational structure and distinctive features that differentiate it from other social relationships. We then review methods and findings from research on infants’ understanding of people and social relationships. We propose that even before infants can use language, they may understand caregiving as an abstract intuitive theory with some features in common with how adults think about caregiving. In particular, infants understand care relationships as intimate, altruistic, and asymmetric. We review work that starts to shed light on this proposal, including the findings that infants distinguish between intimate relationships and merely positive ones and that they have asymmetric expectations of responses to distress in intimate relationships between large and small individuals. The proposal that infants can make these inferences has societal and political implications for how we structure caregiving in early life.
The Human Geography of Care
Authors: Growney Claire M. , Zaloom Caitlin , Carstensen Laura L.
Published: February 2025

The exponential increase in life expectancy in the twentieth century, coupled with a significant drop in fertility in the twenty-first century, demands rethinking family-based care for older people who require assistance with activities of daily living. We argue that age diversity in the population and a trend toward urbanization represent two emerging resources on which new care models can be built. By distributing care among age-diverse groups of kin and non-kin who live in close geographical proximity, demands on individuals can be minimized and social exchanges across generations can build social bonds. In this essay, we discuss features of cities and social infrastructures that can contribute to distributed models of community-based care and provide examples of ongoing efforts that can be scaled nationally and internationally.
Care of the Dead: Ancestors, Traditions & the Life of Cultures
Authors: Ford Phil , Foster Jacob G. , Martel J. F.
Published: February 2025

Humans stand apart from other animals in OUR care for children and elders. We are most distinctive, however, in our care for the dead. Such care is fraught in a modern episteme marked by disenchantment. Beginning with an analysis of exemplary individual relationships with the dead, we develop a theory of the complex links that bind present to past. Through the traces they leave, the traditions they transmit, and the institutions they build, the dead participate in countless chains of causally linked neural and material representations. These should be viewed as living things sustained by attention, memory, and action. Contemporary politics and cultural economies have disrupted our relations with the dead, seeking to control the past for present ends. We call instead for the relationship cultivated with the dead in the humanities, one that emphasizes our shared limitations, our shared fate, and our shared responsibility to make the world from the possible.
V2C-Long: Longitudinal Cortex Reconstruction with Spatiotemporal
Correspondence
Authors: Bongratz Fabian , Fecht Jan , Rickmann Anne-Marie , Wachinger Christian
Published: February 2025

Reconstructing the cortex from longitudinal magnetic resonance imaging (MRI) is indispensable for analyzing morphological alterations in the human brain. Despite the recent advancement of cortical surface reconstruction with deep learning, challenges arising from longitudinal data are still persistent. Especially the lack of strong spatiotemporal point correspondence between highly convoluted brain surfaces hinders downstream analyses, as local morphology is not directly comparable if the anatomical location is not matched precisely. To address this issue, we present V2C-Long, the first dedicated deep learning-based cortex reconstruction method for longitudinal MRI. V2C-Long exhibits strong inherent spatiotemporal correspondence across subjects and visits, thereby reducing the need for surface-based post-processing. We establish this correspondence directly during the reconstruction via the composition of two deep template-deformation networks and innovative aggregation of within-subject templates in mesh space. We validate V2C-Long on two large neuroimaging studies, focusing on surface accuracy, consistency, generalization, test-retest reliability, and sensitivity. The results reveal a substantial improvement in longitudinal consistency and accuracy compared to existing methods. In addition, we demonstrate stronger evidence for longitudinal cortical atrophy in Alzheimer’s disease than longitudinal FreeSurfer.
A Tree G Lows in Calgary
Authors: Schwirck Samantha
Published: February 2025

Massive tree-shaped sculptures take on color-changing hues, but stay true to their roots
Research
Authors: Stuart Daniel , Jackson Cori
Published: February 2025

Electrical Compatibility of MR16 LED Replacements
Evaluating the quality of task/ambient lighting
Authors: Shemitz Sylvan R.
Published: February 2025

Fifteen rules of thumb for judging TAL
Examining Understandings of Racial Equity Among Career Services Professionals
Authors: Buford Melanie Vanleer
Published: February 2025

American colleges and universities have been called upon to provide equitable career preparation for an increasingly racially diverse student body, yet little research has been done to examine understandings of racial equity among career professionals. This qualitative case study examined perspectives on racial equity among career professionals in a university career center. Career center documents were analyzed, services were observed, and semi-structured interviews ( N = 11) with center leaders, staff, and students were conducted and analyzed using Reflexive Thematic Analysis. Data was interpreted through the lens of colorblindness, a conceptual model which promotes the minimization or denial of race and racism. Findings illuminated the presence of different dimensions of colorblindness—interpersonal, educational, organizational, legal, and societal—in the perspectives of participants, including tension around staff and administrator awareness and consideration of race in their practice. Implications for career research, policy, and practice are discussed.
The impact of weak inertial stimulation on visual-vestibular bimodal heading perception
Authors: Wei Yue , Bao Beisheng , Xie Jingyi , So Richard HY
Published: February 2025

Perception of self-motion involves the integration of visual and vestibular sensory information. Currently, there is limited research exploring visual-vestibular interactions under weak vestibular stimulation. This study investigates the impact of weak inertial stimulation on visual-vestibular bimodal heading perception. A translational XY-axis motion platform equipped with a 46-inch LCD TV was utilized to generate synchronized visual and inertial stimuli. The heading perception was examined under visual-only, vestibular-only, and bimodal conditions using three levels of inertial stimuli (9 mg, 14 mg, and 19 mg). In each condition, participants were tested at nine angles (±16°, ±9.2°, ±3°, ±1.7°, and 0° where 0° represents forward movement), to discern left-forward or right-forward motion. The heading discrimination threshold (HDT) was derived from participants’ rightward response proportions across all angles. Our findings reveal that the HDT under 14 mg bimodal conditions is significantly higher than that under visual-only conditions (with marginal significance in the 9 mg and 19 mg conditions), indicating that the presence of weak vestibular signals might decrease the precision of bimodal heading discrimination. These results contradict the prediction of Bayesian model theory that perception is more precise under bimodal compared with unimodal conditions. The results may be explained by neurological biases during Bayesian integration, the “reduced visual precision” theory, or increased task complexity in bimodal heading discrimination. Further research with larger sample size, extending the study to varied inertial stimuli and visual coherence levels, will be beneficial for clarifying its underlying mechanisms.
Assessing gait variability concurrently with dynamic visual acuity on a treadmill in people with bilateral vestibulopathy
Authors: McCrum Christopher , Zhu Meichan , Willems Paul , Visser Ivar , Kastrinou Melina , van de Berg Raymond , Meijer Kenneth , Hallemans Ann , Herssens Nolan
Published: February 2025

Background

Gait variability is increased in people with bilateral vestibulopathy (BVP). Since dedicated gait analysis can be resource-intensive, concurrent assessment with another vestibular function test, dynamic visual acuity (DVA), is worth consideration.

Objective

To assess comparability of results from a combined gait and DVA assessment with results from a previous dedicated gait analysis.

Methods

15 participants (4 women) with BVP were analysed. The DVA test assessed visual acuity during stance and during treadmill walking at 2, 4 and 6 km/h. An 8-camera motion capture system measured spatiotemporal gait parameters (step length, step time, step width and double support time; means and coefficients of variation [CoV]). The walking speed effect was assessed by mixed-effects models, and results were visually compared to previous results.

Results

Walking speed affected the means of step length, step time and double support time ( p < .0001) but not step width ( p = .373) and significantly affected the CoV of all parameters ( p < .01). These values, as well as speed-related changes, were comparable between contexts.

Conclusions

Concurrent DVA and gait assessment seems promising as an assessment method in people with BVP. Test-retest reliability, clinically feasible motion capture solutions and sensitivity to change following interventions should be further investigated.
Comparison of the impacts of percussion massage therapy, dynamic stretching, and kinesiology taping techniques on functional performance, muscular strength, and proprioception in the shoulder
Authors: Menek Burak , Tayboga Umut Islam
Published: February 2025

Background

Percussion massage therapy (PMT) integrates traditional massage with vibration therapy.

Objective

This study compared the effects of percussion massage therapy (PMT), kinesiology tape (KT), and dynamic stretching (DS) on shoulder strength, proprioception, and functionality.

Methods

The KT group had kinesiology tape applied to the deltoid muscles. The DS group performed dynamic stretching in flexion and abduction. The PMT group received percussion massage on the deltoid muscles. Assessments included the Becure system for joint position sense (JPS), the Timed Functional Arm and Shoulder Test (TFAST), and a hand-held dynamometer for muscle strength.

Results

Significant improvements were observed in almost all JPS parameters for all groups (p < 0.05). Total TFAST scores improved in all groups. Muscle strength significantly improved in the DS group (p < 0.05), while PMT and KT groups showed no significant change (p > 0.05). Statistically significant differences were found between the groups (p < 0.05). JPS 30°, 60°, and 90° flexion parameters had effect sizes of 0.51, 0.64, and 0.49, respectively; JPS 30°, 60°, and 90° abduction parameters had effect sizes of 0.38, 0.46, and 0.45, respectively. The effect size for Total TFAST was 0.55, flexion muscle strength 0.59, and abduction muscle strength 0.68. DS was more effective for muscle strength, DS and PMT for functionality, and KT and PMT for proprioception (p < 0.017).

Conclusions

PMT and KT were more effective for proprioception, PMT and DS were more effective for functionality, and DS was most efficient in enhancing muscle strength.