bluuebunny/crossref_metadata_2025 huggingface dataset:
The Ship’s Propeller Rotation Threshold for Coral Reef Ecosystems Based on Sediment Rate Indicators: Literature Review with Bibliometric Analysis and Experiments
Authors: Kadir Abdul , Istadi I. , Subagio Agus , Waluyo W. , Muis Abdul
Published: February 2025

The rotation of ship propellers produces water flows that can trigger erosion and resuspension of sediment on the seabed, which damages coral reef habitats. The causal relationship between propeller rotation and coral reef damage must be known to obtain the necessary environmental constraints. This research uses bibliometric analysis and experiments to determine safe propeller rotation thresholds based on sediment rate indicators. The water flow velocity from the propeller rotation was measured through experiments in various rotations. The sedimentation rate is determined using empirical calculations based on the water flow velocity value. The analysis results determine that the rotation threshold for a propeller diameter (Dp) of 1.5 m is: (a) 120 rpm if the vertical position of the propeller axis is 0.5Dp above the seabed; (b) 230 rpm if the vertical position of the propeller axis is 1.0Dp above the seabed; and (c) 360 rpm if the vertical position of the propeller axis is ≥ 1.5Dp above the seabed. The results of this research become a benchmark for the environmentally friendly operation of ship propellers.
Plant Anatomy: Definition, Classification of Plant Organs and Tissue, and Design of a Visuospatial Transformation Learning Model for Teaching Biology
Authors: Suprapto Purwati Kuswarini , Ardiansyah Ryan , Diella Dea , Chaidir Diki Muhamad , Hendrawan Al Maidah , Diana Sari Wulan , Amarulloh Adhitya
Published: February 2025

This research aims to develop a 3-dimensional (3D)-based learning model with Visuospatial Transformation Learning (VTL). We used the Design-Based Research (DBR) research method which was tested on fifth-semester biology students regarding plant anatomy material. The results showed an increase in visual representation abilities in the high category. Students can identify cell shapes in detail based on cell and tissue structures. The VTL model provides a dynamic learning experience. Visualization and transformation of 2D into 3D is easy to understand because students have gone through the learning stages using VTL including (i) independent learning, (ii) making concept maps, (iii) discussing concept maps, (iv) practicum and 2D representation, and (v) representation 3D so students can understand the structure of plant tissues and organs in detail. The VTL model is recommended for learning other abstract material. The impact of using this model is that students can understand abstract material more quickly and help the development of science and its application better.
Implementation of the Snowball Throwing Method with Wordwall Learning Media to Increase Students' Learning Interest and Motivation in Software and Game Development in SMKN 4 Bandung
Authors: Aini Qurratu , Trianasari Amilia , Dwi Prasojo Sigit
Published: February 2025

The purpose of this study is to increase the interest and motivation of students using the snowball throwing method with wordwall media in learning Software and Game development subject (PPLG) of class X at SMKN High School 4 Bandung. The method used by the researcher is the Classroom Action Research method. The subjects of the study were 36 students. This study was conducted in one cycle by conducting a pre-cycle at the beginning of the study, which consisted of four components, namely Planning, Implementing actions, Observation, and Reflection. The results of the study showed an increase in interest and motivation to learn which had an impact on the learning completion (scoring 75 and above) of students per cycle. In the pre-cycle, 6 students or 17% achieved the said learning completion. In cycle I, there were 28 students or 78% who achieved the learning completion. This indicates that using the snowball throwing method with media was successful and had successfully exceeded the 75% criteria of student’ completion.
Implementing Problem-based Learning using Multimedia to Improve Cognitive Students
Authors: Erlangga Erlangga , Fahrezi Mochamad Pahmi , Nugraha Eki
Published: February 2025

The 2016 UNESCO Global Education Monitoring (GEM) Report explained that Indonesia ranked fifth from the bottom among 14 other developing countries in terms of education quality. Quality education should not only focus on results but also emphasize the learning process. The purpose of this research is to apply the Problem-Based Learning (PBL) model in multimedia to improve students' cognitive abilities as part of problem-solving techniques. The research method used is RD with the ADDIE multimedia development model and a One-Group Pretest-Posttest research design. The findings indicate an improvement in students' cognitive abilities through the application of the PBL model in informatics learning multimedia. This improvement in cognitive abilities demonstrates an enhancement in students' problem-solving skills. Since cognitive aspects are integral to problem-solving techniques, an increase in cognitive ability corresponds to better problem-solving skills. Additionally, the improvement is evident in the student's learning outcomes, which increased from an average of 62.17 (pretest) to 80.33 (post-test). The t-test results confirmed that the increase in student learning outcomes was statistically significant. Furthermore, the average score of student responses to the multimedia was 84.4%, categorized as “Very Good.”
Bringing AI APIs into the Classroom with a JavaScript Coding Site
Authors:   School of Computing, Dublin City University, Glasnevin, Dublin 9, Ireland, Humphrys Mark
Published: February 2025

With the growth of large-scale Artificial Intelligence (AI) models has come the growth of AI Application Programming Interfaces (AI APIs), where the model remains at the remote site, and is called remotely via an API. The goal of this work is to bring accessible coding for AI APIs into the classroom. This paper describes two key innovations. First, a new JavaScript coding site, “Ancient Brain”, designed for education with a focus on AI. And second, the building of an extensive set of open-source JavaScript AI API programs that can be run by students in the browser and can also be edited and modified by students in the browser (on Ancient Brain). A search of coding sites struggles to find any comparable collection of AI API JavaScript programs for students in existence anywhere. While AI APIs can be called in any programming language, this paper discusses the advantages of a JavaScript-based system. We discuss issues such as public versus hidden code, API key management, API response delays and CORS issues, with consideration of how to address these in an educational environment. Future work would be to build AI API exercises for secondary school students using this starter collection.
Idea zrównoważonego rozwoju w obronności i przemyśle zbrojeniowym
Authors: Łowicki Bartosz
Published: February 2025

The idea of sustainable development in defense and arms industry. This chapter aims to discover whether it is possible to develop a reasonable compromise between the idea of sustainable development, the arms industry and defense. Seemingly opposite ideas and sectors have much in common. The aforementioned shared part may be
key to solving the problem together. In the case of defense, there are solutions that provide an
increase in defense capabilities and an environmental benefit. The arms industry is, however,
difficult to be made sustainable. This sector is unsustainable in nature and its guiding idea is
imbalance. This imbalance is becoming apparent in the turnover of arms companies, whose
huge profits are fuelled by the arming of countries. Trade of this magnitude takes place
despite the existence of various conventions prohibiting war—the UN Charter, for example.
In the case of defense, however, sustainability does not have to be an antonym. This chapter
does not encourage the implementation of militarism nor of environmentalism. The desired
approach is the one that is most beneficial to humans (defense) and the environment on
occasion. Therefore, it seeks arguments supporting the thesis that it is possible to invest in
defense in a thoughtful way with respect for the environment. Observing the scale of the
problems of the modern world—wars and conflicts, it is necessary to take reasonable action
while there is still time.
Rola funduszy Unii Europejskiej w promowaniu zrównoważonego rozwoju
Authors: Dyrlica Mateusz
Published: February 2025

The role of European Union funds in promoting sustainable development. This chapter analyses the impact of European Union funds on achieving sustainable development goals. The EU budget, although it constitutes only 1% of the entire Union’s GNI, plays a key role in financing initiatives supporting sustainable development. This chapter
presents the history of the EU’s sustainable development policy, with particular emphasis
on funds such as the European Regional Development Fund, the Cohesion Fund, and the
European Social Fund+, including the latest initiatives, like the “Europe 2020” strategy and
the “Fit for 55” package, aimed directly at combating climate change and supporting the
transition to a sustainable economy. The analysis includes a critical review of both Polish
and foreign literature, as well as source materials and statistical data from EU institutions,
highlighting the importance of the EU budget policy in supporting sustainable development,
particularly in relation to Poland within the financial perspective for 2021–2027.
(Nie)sprawiedliwość klimatyczna w Unii Europejskiej
Authors: Kwiatkowska Agata , Rogowski Wojciech
Published: February 2025

Climate (in)justice in the European Union. Responsibility for global warming is distributed unequally, and its effects are much more severe for the poor, who emit relatively little, than for the rich. Unfortunately, most
climate policies to date have placed the greatest financial burden on the lower and middle
classes, translating into a sense of injustice among citizens, as well as opposition to such
policies. The following chapter discusses this problem from the perspective of the European
Union member states: it describes the said opposition and aims to understand its causes. It
seems important to ensure that the costs of future policies are mainly borne by the largest
emitters, while less advantaged groups should receive additional support. Otherwise, there
might occur a rise in inequality, a loss of trust in the government and opposition to its
policies, making it impossible to effectively fight climate change.
Kredyty SLL w Polsce – sytuacja obecna i perspektywy
Authors: Michowska Kamila
Published: February 2025

Sustainability Linked Loans in Poland—current situation and perspectives. Sustainability Linked Loans (SLL) have gained increasing attention in Poland,
reflecting a broader global trend in sustainable finance. The aim of this chapter is a comprehensive overview of SLLs, comparing the Polish and international markets and evaluating
the future prospects of this financial instrument. The study reviews industry standards and
examines Key Performance Indicators (KPIs) used in SLLs, assessing their alignment with
standards. Findings show, that while SLLs became globally used due to their flexibility, the
Polish market is still developing. Environmental KPIs are prevalent in SLLs, whereas social
KPIs are less common due to measurement challenges. The paper also notes a recent decline
in SLL issuance, likely influenced by stricter EU regulations and high auditing costs.
Fair Trade jako odpowiedź na wyzwania globalizacji
Authors: Jankowska Olga
Published: February 2025

Fair trade as a response to the challenges of globalisation. The aim of this chapter is to identify how Fair Trade practices address some of the contemporary global challenges arising from the processes of globalisation. Methods
include analysis of the literature, reports, data, and information from organisations such
as Fairtrade International, Fairtrade Poland, the Polish Fair Trade Association, the World
Fair Trade Organization, the World Bank, and the United Nations. Fair Trade focuses on
achieving social, environmental, and economic goals, especially in addressing poverty. Fair
Trade is a social movement enhancing social awareness about global challenges and also
a market of products that meet Fair Trade criteria. It aims to improve the living conditions of
marginalised communities by tackling the negative impacts of globalisation and supporting
sustainable development.
Water Sustainability in Lebanon
Authors: Zaidan Mahdi
Published: February 2025

This review covers four facets of Lebanon’s water resources. The first is an overview of water sustainability issues in Lebanon, ranging from policies to politics affecting the use, treatment and distribution of water. The second section considers the question of equality of access to water, focusing particularly on affordability, refugees, and water rights. In the third section, the politics of transboundary water resources, particularly those of the Orontes and the Jordan River Basin are outlined in detail. The last section explores the impact of climate change on Lebanon’s water resources.
Consideraciones clave: Participación infantil en el contexto de brotes de enfermedades en África Oriental y Meridional
Authors: Reilly Elena , Serlemitsos Elizabeth , Sebba Bilakwate Julieth
Published: February 2025

Las estrategias eficaces de participación infantil son fundamentales para optimizar la respuesta a los brotes de enfermedades y minimizar su impacto, y garantizar al mismo tiempo la protección, el bienestar y la resiliencia de las niñas y niños. Cuando estas entienden los brotes de enfermedades, desarrollan una mejor capacidad para afrontarlos, contribuir y recuperarse. Esto promueve su bienestar y los protege y reconoce su capacidad de actuar. La región de África Oriental y Meridional (ESA, por sus siglas en inglés) es propensa a sufrir brotes de enfermedades como el ébola y otras fiebres hemorrágicas, el sarampión, el cólera, el ántrax y la meningitis, que pueden afectar de forma desproporcionada a las niñas y niños. Este informe explora por qué, cuándo y cómo se debe incorporar a las niñas y niños en las fases de prevención, respuesta y recuperación. Basándose en la bibliografía gris y publicada, incluidos informes de proyectos, y en la amplia experiencia de los autores, ofrece orientación para apoyar el diseño y el desarrollo de estrategias de comunicación y participación de temáticas relacionadas con los brotes de enfermedades que se adapten a las infancias. El informe abarca labores que cuentan con la contribución de niñas, niños y adolescentes menores de 18 años y recomienda tres niveles de participación. Las organizaciones y los profesionales pueden elegir el nivel en función de sus objetivos, recursos y disposición a trabajar con las niñas y niños.
Capacitación en liderazgo en estudiantes de enfermería
Authors: Mosca Ana María María , González Lucía Mabel
Published: February 2025

Para muchos autores, el líder influye, cultiva y motiva a quienes trabajan con él. No obstante, para que se logren los objetivos en una institución, no solo se debe contar con quienes guíen al alcance de dichas metas en tiempo y forma, sino que, además, cuenten con los recursos necesarios.
Este rol no necesariamente está asociado al cargo. De acuerdo con Becerra-Sarmiento (1), hay diferencias. Para el autor, los líderes cuentan con un estilo que influye en su entorno. Paralelamente, otros estudios muestran que los subalternos buscan un modelo (2), lo que conlleva una mayor responsabilidad y compromiso para ser un ejemplo, considerando que quienes no tengan estas características tendrán un resultado poco favorecedor, ya que el equipo de trabajo es el que acepta o rechaza al líder.
Un líder empático que orienta a su equipo de trabajo provoca la colaboración de todo el equipo sin la necesidad de ocupar un rol organizacional, ni tampoco un cargo, porque es una cualidad de la persona. Bracamonte L. (3), en un artículo denominado Estilos de liderazgo en jefes de servicios de enfermería, manifiesta que en muchos casos el líder es el que determina la productividad del grupo, a diferencia de un gestor que, sin cualidades de liderazgo, impone o busca solo la obtención de resultados. Si bien ambos son importantes, si el gestor no tiene o no desarrolla el liderazgo, no podrá materializar exitosamente los proyectos.
El crecimiento técnico científico de salud ha hecho que las carrera afines adapten sus perfiles profesionales a las necesidades político-sociales del país. En particular, en el colectivo de enfermería, se produjo una reconceptualización a partir de estas exigencias, las que estimularon el consenso de contenidos y el aporte de nuevos temas, incluyendo conceptos de otras disciplinas originadas de la psicología y la comunicación social, las que son altamente aplicadas en el gerenciamiento de recursos humanos, y el liderazgo profesional, conjugando estos elementos entre la institución, las autoridades y los propios profesionales y empleados que trabajan o se vinculan.
Siendo la carrera de enfermería una de las pioneras en incorporar temas ligados al liderazgo, como técnicas de negociación, comunicación, oratoria, resolución de conflictos, entre otros, el presente artículo tiene el objetivo hacer visible el fundamento de por qué es necesario desarrollar estos conceptos en los estudiantes de enfermería durante la carrera.
The Effect of Intravenous Glutamine Administration in Lowering AIF Expression in Renal Tubular Cells
Authors: Raihan Akbar Muhammad  , Imam Susilo  , Eko Budi Koendhori  , Bambang Purwanto
Published: February 2025

Highlights

Glutamine, an amino acid, can help mitigate the side effects of cisplatin by boosting glutathione (GSH) levels, an antioxidant that counteracts oxidative stress.
By reducing AIF protein expression and apoptosis, glutamine may protect kidney cells from cisplatin toxicity, potentially improving the safety of chemotherapy.

Background: Cisplatin, a widely used chemotherapy that is effective for many forms of cancer, has nephrotoxic qualities that can reduce renal function. Due to its side effects, the usage of cisplatin is limited by its dose. Glutamine, an amino acid, possesses properties that can counteract the nephrotoxicity of cisplatin. Objective: This study aimed to analyze the effect of intravenous glutamine administration on the decrease of AIF expression and apoptosis in intraglomerular mesangial cells of cisplatin-exposed rats. Material and Method: Samples (n) consisting of 30 rats were divided into 3 groups, with each group containing 10 rats. Group P0 received no treatment, group P1 received an injection of cisplatin on the 7th day, and group P2 received glutamine on the 1st–7th day and an injection of cisplatin on the 7th day. After 72 h, the tissue samples were immunohistochemically processed and then observed under a light microscope with 400x magnification. AIF expression and apoptosis were measured in the Allred/H score. Result: AIF expression results were: P0 = 4,35(2,2-5,4); P1 = 5,9(4,8-6,3); P2 = 5,25(2,4-5,8). The AIF expression of P2 was found to be significantly lower (p = 0.008) than P1. Apoptosis results were: P0 = 5,2(4,7-5,5); P1 = 6,4(6,1-7,1); P2 = 5,7(4,8-5,9). The apoptosis level of P2 was found to be significantly lower (p = <0.0001) than P1. Strong correlations between the decrease in AIF expression and the apoptosis level were found (p = <0.0001). Conclusion: Glutamine contributes to the decreased AIF expression and apoptosis in intraglomerular mesangial cells of cisplatin-exposed rats.
Research on Ginger Price Prediction Model Based on Deep Learning
Authors: Li Fengyu , Meng Xianyong , Zhu Ke , Yan Jun , Liu Lining , Liu Pingzeng
Published: February 2025

In order to ensure the price stability of niche agricultural products and enhance farmers' income, the study delves into the pattern of ginger price fluctuation rule and its main influencing factors. By combining seasonal decomposition STL, long and short-term memory network LSTM, attention mechanism ATT and Kolmogorov-Arnold network, a combined STL-LSTM-ATT-KAN prediction model is developed, and the model parameters are finely tuned by using multi-population adaptive particle swarm optimization algorithm (AMP-PSO). Based on an in-depth analysis of actual data on ginger prices over the past decade, the STL-LSTM-ATT-KAN model demonstrated excellent performance in terms of prediction accuracy: its mean absolute error (MAE) was 0.111, mean squared error (MSE) was 0.021, root mean squared error (RMSE) was 0.146, and the coefficient of determination (R²) was 0.998.This study provides the Ginger Industry, agricultural trade, farmers and policy makers with digitalized and intelligent aids, which are important for improving market monitoring, risk control, competitiveness and guaranteeing the stability of supply and price.
Research Hardware Publications Should Help Build Communities, Careers and Better Hardware
Authors: Colomb Julien , Maxeiner Moritz , Mies Robert
Published: February 2025

Based on the interviews of fifteen contributors in research hardware projects, we shed lights onto the motivations of research hardware engineers to use a hardware publication platform, and derived some high-level features that such a platform should have. Our analysis suggests that the main objectives of the authors are to find their readership and grow an inclusive community of contributors, producers and users around their project. Inclusivity requires the recognition of different types of contributions and a system free of financial or language barriers for authors and readers. They also appear interested in getting feedback on their work, in order to make the hardware better and learn during that process. The creation of a research output that is recognized by the academic system is also important both for their career and for developing their community. In addition, they express wishes for a publication system integrated in their hardware documentation workflow , as well as a system which would be pleasant or even fun to use. Importantly, a research hardware publication ecosystem should link archived and living versions of the hardware project and consider the project as a whole, providing documentation on both the hardware product and the development process.
Emotional Labor in Pediatric Palliative Care: A Scoping Review
Authors: Costa Ana Inês Lourenço da , Barros Luísa , Diogo Paula
Published: February 2025

Background: Caring for children in palliative care especially impacts healthcare professionals' personal and professional lives. Their emotional experience and needs are frequently forgotten. Healthcare professionals face emotional demands when caring for children with palliative needs and their parents. Objective: This scoping review aims to identify and map the scientific production about the emotional labor of healthcare professionals in pediatric palliative care. Methods: This scoping review was conducted according to the JBI recommendations and the PRISMA Extension for Scoping Reviews. We searched 16 electronic databases in August 2023. Articles were screened according to inclusion criteria, and a thematic analysis allowed for a summary of key findings. Results: Ten publications were selected. Most studies were conducted in the United States of America and with nurses as the professionals involved. Many publications were qualitative studies and developed in a neonatal intensive care context. Using content analysis, five themes were identified: (1) emotional experience of healthcare professionals (2) relational context involved (3) managing professional and personal boundaries (4) intrapersonal strategies of emotional labor (5) and social and organizational strategies of emotional labor. Conclusions: The importance of implementing emotional labor strategies is highlighted, especially intrapersonal, social, and organizational. Education, training, and reflection are needed within a workplace culture that recognizes emotional experiences and supports the emotional management of healthcare professionals. Emotional labor in pediatric palliative care should be recognized. Further research in this area is needed.
Concizumab, a Non-replacement Therapy for Persons with Hemophilia with Inhibitors
Authors: Castaman Giancarlo , Jimenez-Yuste Victor , Mahlangu Johnny
Published: February 2025

Despite enormous progress in the development of therapeutic agents for persons with hemophilia A and B (HA, HB), several unmet needs persist. These are disease- and treatment-related. Prophylaxis with clotting factor replacement is the gold standard but not feasible in HA and HB with inhibitors. Whereas persons with HA with inhibitors can receive prophylaxis with a factor-mimicking agent, emicizumab, there is no recommendation on the agents to use as prophylaxis in persons with HB with inhibitors, as there are no available molecules. Concizumab is a novel, subcutaneous prophylaxis option in persons with HA or HB with inhibitors that can potentially improve long-term outcomes. Here, we review the available data on concizumab and discuss its possible positioning in the armamentarium to treat hemophilia with inhibitors.
Numerical Modelling of Steel Frames with Masonry Infilled with and with Rubber Bricks at the Corners (SISBRICK)
Authors: Aguero Antonio
Published: February 2025

The purpose of this article is to use a numerical model to match the experimental results in case of steel frames with infilled masonry with or without rubber bricks at the corners (SISBRICK) under cyclic loading. The analysis are performed with opensees software using for preprocessing and postprocessing matlab. In this model the beam and column made of steel are modelled with displacement based elements and using section fiber models at each fiber the Giuffre Menegotto Pinto is used, to model the infill masonry with or without SISBRICK the concrete model based on Thorenfeldt curve is used to model the diagonals with high strength under compression and low under tension.
Properties of Tungsten Carbide Rings When Compressed to Failure or Cut with a Diamond Grinding Bit
Authors: Quinto Ernesto S. , Reyes Nathan P. , Steimel Joshua P. , Lee JuEun , Dowbak John M.
Published: February 2025

Background:

Tungsten carbide rings are increasingly popular modern jewelry items. Tungsten carbide is an extremely dense, hard metal. Previously described methods to remove tungsten carbide rings include using locking pliers to compress the ring or cutting the ring with a high-speed dental drill.

Methods:

A universal mechanical testing system (MTS) machine was used to diametrically compress tungsten carbide rings 9 mm in length and 2.4 mm in thickness with a 23.4-mm outer diameter and a 21.0-mm inner diameter while measuring the force required to fracture the rings. A computer numerical control (CNC) machine was used to cut tungsten carbide rings with a diamond grinding bit with and without a flow of normal saline solution. An infrared thermal camera was used to record the temperature at the site of contact between the ring and the grinding bit and at a site one-quarter of the circumference along the ring.

Results:

A mean force with 95% confidence interval of 3.7 ± 1.2 kN was required to fracture the tungsten carbide rings via diametral compression (p = 0.05). The rings failed at a mean displacement with 95% confidence interval of 0.32 ± 0.13 mm (p = 0.05). The maximum temperature observed at the site of contact between the ring and grinding bit averaged 160.2°C including cases with and without coolant. The time to reach maximum temperature and the duration of maximum temperature differed significantly between the cases with and without coolant (p = 0.0007 and p = 0.0108, respectively).

Conclusions:

Tungsten carbide rings fractured with minimal displacement using a small amount of force via diametral compression. The brittle fracture pattern of the rings produced minimal comminution. Tungsten carbide rings reached extreme temperatures when cut with a high-speed diamond grinding bit despite cooling with normal saline solution.

Clinical Relevance:

Previously documented methods to remove a tungsten carbide ring include breaking the ring by compressing it with pliers or cutting it off with a high-speed dental drill. Clinicians should be aware of potential complications of current methods to remove tungsten carbide rings.
Efectos de biofertilizantes en la calidad y producción de Lactuca Sativa L. Bajo un sistema agroforestal de Pouteria Lucuma (Ruiz & Pav.) Kuntze en Macas, Lima
Authors:   , Campana Ovalle Bertil
Published: February 2025

La producción tradicional de Lactuca sativa L. implica el uso excesivo de fertilizantes nitrogenados sintéticos, lo que degrada negativamente las propiedades biológicas, físicas y químicas del suelo. En contraste, los biofertilizantes orgánicos mejoran el microbiota del suelo, y contribuyen a la reducción de gases de efecto invernadero (GEI). Este estudio evaluó el efecto de los biofertilizantes en el rendimiento de Lactuca sativa L. (var. Longifolia) dentro de un sistema agroforestal con Pouteria lucuma (Ruiz & Pav.) Kuntze y en un sistema convencional con exposición solar directa. Se analizaron la expresión fenotípica y la calidad fenológica del cultivo mediante la toma de muestras de lixiviados, agua y suelo, aplicadas mediante drench para cada tratamiento. En un área de 356,4 m² se tuvo una población inicial de 864 plantas para evaluar la fenología de ambos sistemas, para la evaluación final se obtuvieron 180 plantas mediante un esquema de muestreo estratificado aleatorio simple. Los datos se analizaron utilizando un diseño de bloques completos al azar (DBCA) con tres repeticiones por sistema (Sistema Solar Directo [SOL] y Sistema Agroforestal [SAF]) y seis tratamientos en cada uno. Los resultados mostraron diferencias significativas entre los sistemas en términos de expresión fenotípica y calidad (P < 0.05). Los biofertilizantes tuvieron un efecto positivo en el tamaño de la raíz y el diámetro del cogollo, y mejoraron el ancho y largo de la hoja.
Asociación entre mortalidad y antecedentes de fracturas en pacientes adultos mayores
Authors:   , Sanchez Tapia Jesus Paolo , Jimenez Salvatierra Liliana Milagros
Published: February 2025

Introducción: El aumento en la expectativa de vida, las modificaciones fisiológicas vinculadas al envejecimiento, y afecciones como la osteoporosis y la fragilidad, elevan la vulnerabilidad a las fracturas en la población de edad avanzada. Nuestro objetivo fue determinar la asociación entre antecedentes de fracturas y mortalidad en adultos mayores, estratificados según edad, sexo, funcionalidad y fragilidad en un hospital de alta complejidad. Materiales y Métodos: Se llevó a cabo un análisis observacional, analítico y retrospectivo secundario basándose en datos del ""CEMENA Frailty Study"" (2010-2016), que abarcó a 1896 adultos de 60 años atendidos en el Centro Médico Naval del Perú. En este estudio, se examinaron factores como la edad, el género, la dependencia funcional, la fragilidad física y el historial de fracturas. La tasa de mortalidad se registró mensualmente y los estudios estadísticos se llevaron a cabo a través de la regresión de Cox. Resultados: El antecedente de fracturas estuvo presente en el 6.75% (n=128) de la población estudiada y la mortalidad fue del 10.13% (n=192). Encontrándose un riesgo de mortalidad significativamente mayor en pacientes con fracturas, especialmente en mujeres y en aquellos con dependencia funcional o fragilidad física. Conclusiones: Los adultos mayores con antecedentes de fracturas, particularmente mujeres y aquellos con dependencia funcional o fragilidad física, presentan un riesgo elevado de mortalidad. Por ello, resaltamos la importancia de realizar un manejo integral de las personas con condiciones de salud, buscando la optimización de la capacidad funcional que le permita vivir con bienestar y reducir el riesgo de mortalidad temprana.
Atopic skin inflammation promotes systemic anaphylactic responses via IL-13 signaling in conventional dendritic cells.
Authors: Kubo Masato , HARADA YASUYO , Sasaki Takanori , Obata-Ninomiya Kazushige , Matsuyama Takahiro , Ueha Satoshi , Shichino Shigeyuki , Watanabe Takashi , Wu Bin , Ogawa Shuhei , Ki Sewon , Suzuki Yoshie , Ueno Hideki , Ziegler Steven , Inoue Hiromasa , Burrows Peter , Murphy Kenneth , Kim Brian
Published: February 2025

Cutaneous allergen sensitization (CAS) underlies atopic dermatitis (AD) and leads to various allergic symptoms, including food allergy and anaphylaxis. IL-13 expression by T follicular helper T (TFH) has been reported to be involved in generating high-affinity IgE antibodies and causing systemic anaphylaxis.1, 2 However, the mechanisms by which IL-13 triggers IgE-mediated allergic responses remain poorly defined. In the present study, we elucidate the role of IL-13 in the CAS-mediated mechanism by which high-affinity IgE antibodies are produced when the same allergen is introduced at a distal site in the secondary sensitization. The CAS model system using mice lacking the cell lineage-specific IL-13 receptor (IL-13R) demonstrated that dendritic cells (DCs), but not T or B cells, are critical in the high-affinity IgE-mediated anaphylactic response. The IL-13 signal in type 2 conventional DCs (cDC2s) enhanced the expression of MHC class II and CD301b, which was essential for the recall of type 2 responses, inducing the production of high-affinity IgE antibodies. Similar IL-13R-expressing DCs were identified in allergic rhinitis and food allergy patients with a history of AD. These findings strongly suggest the importance of DC-specific IL-13 signaling in CAS-induced allergic reactions associated with the atopic march, which is common in human AD patients.
The impact of simulation with debriefing on developing clinical competence and performance in paramedicine students
Authors: Veronese Jean-Paul , Crowther Grace , Lee Patricia , Boyle Malcolm
Published: February 2025

Introduction
Paramedics handle diverse medical and trauma cases, where any lapse in competency can compromise patient safety. Student paramedics must meet high standards set by oversight bodies to protect both the profession and the public. Growing evidence indicates that simulation facilitates attainment and reinforcement of clinical competencies. However, limited evidence explores the impact of simulation and debriefing on developing clinical competence in undergraduate paramedicine students.
Aim
This study aimed to evaluate the association between weekly practice session performance and summative practical exam outcomes, assessing how simulation-based practice supports the development of clinical competence among paramedicine students.
Methods
A retrospective analysis of performance-based assessment data (2019–2024) in a university paramedicine program evaluated the role of high-frequency simulation. Second-year students participated in weekly three hour simulated practice sessions and a summative practical exam, with performance assessed using the Clinical Competence Assessment Tool (CCAT). Practice session data were grouped into tertiles to assess trends. Pearson’s correlation measured the association between practice frequency and exam outcomes, paired samples t-tests evaluated performance progression, and hierarchical regression identified significant predictors of exam outcomes.
Results
Data from 305 students and 1,251 practice scenarios revealed a significant positive correlation between practice frequency and exam performance (rs = 0.257, p < 0.001). Clinical competence scores improved progressively across the trimester, with the strongest correlation observed in the final tertile (rs = 0.229, p < 0.001). Earlier tertiles showed weaker but statistically significant correlations (p < 0.05). A performance dip in 2020 due to reduced simulation exposure during COVID-19 further highlighted the critical role of consistent, high-frequency practice in fostering competence and exam success.
Conclusion
This study demonstrates the value of structured, high-frequency simulation and debriefing in enhancing clinical competence and exam performance. The findings underscore the importance of consistent practice, particularly in the final trimester weeks, supporting its integration into paramedicine curricula to ensure readiness for real-world practice and sustained competence.
Clinical outcomes of translucent monolithic zirconia vs. Lithium base glass ceramic fixed dental prosthesis: a systematic review and meta-analysis.
Authors: Pipatphatsakorn Mayurach , Norchai Pornsuda , Sornsuwan Tanapon
Published: February 2025

Current evidence of comparative clinical outcomes between translucent monolithic zirconia and lithium disilicate remains to be obtained to conclusively determine the superior material for fixed single-crown restorations.
Objectives: To comprehensively compare the three-year clinical outcomes of translucent monolithic zirconia and lithium disilicate in fixed dental prostheses.
Materials and Methods: We searched PubMed, EMBASE, Cochrane CENTRAL, CINAHL, and EBSCO Open Dissertations from inception to November 2023. Randomized controlled trials (RCTs) that compared the clinical outcomes of translucent monolithic zirconia and lithium disilicate in patients requiring fixed prostheses with a minimum follow-up of 6 months were included in this study. This systematic review and meta-analysis were developed and performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and with the guidance of the Cochrane Handbook for Systematic Reviews of Interventions (v.6.2). The risk of bias was assessed by the Cochrane Risk of Bias Tool 2 (RoB-2). This meta-analysis assessed the risk ratio (RR) for the effect size. Statistical analyses were performed via the RevMan5 software program. The protocol was registered with PROSPERO (CRD42023491978).
Results Of the 188 articles identified, four trials were included (n=4). The RRs [95% CIs] for all the outcomes were not significantly different between Tran Zr and LDS: survival rate (1.00 [0.98, 1.02], I2=0%), marginal integrity (0.98 [0.94, 1.02], I2=2%), absence of anatomical change (1.04 [0.98, 1.10], I2=0%), absence of dental caries (1.00 [0.99, 1.01], I2=0%), surface integrity (1.00 [0.92, 1.10], I2=0%), absence of crown fracture (1.00 [0.99, 1.02], I2=0%), absence of abutment fracture (0.99 [0.97, 1.01], I2=0%), and retention (0.98 [0.93, 1.03], I2=30%). The analysis demonstrated that translucent zirconia and lithium disilicate performed similarly across the evaluated outcomes over the 3-year follow-up period, with no significant differences detected.
Conclusions: Translucent zirconia and lithium disilicate have similar three-year survival rates without clinical significance, with either single posterior restorations or heavy bite forces on the multiunit restorations. This review also highlights the knowledge gap in the materials currently used for clinical trials. It requires more supporting evidence from other subjective parameters, such as color match, dentist or laboratory experience, material prices, and patient preferences.
Neurobehavioral profile of individuals with pathogenic variants in CHD3
Authors: Lippe Sarah , Ionescu Anca , Mazur-Lainé Emmanuelle , Proteau-Lemieux Mélodie , Knoth Inga Sophia , Vachon Keely , Whitlock Kerri , Biag Hazel Barlanhan , Rabouhi Nazim , Heesbeen Hendrikus Van , Jacquemont Sebastien , Hessl David , Abbeduto Leonard , Anagnostou Evdokia , Bolduc Francois , Hagerman Randi , Campeau Philippe
Published: February 2025

Snijders Blok-Campeau syndrome (SNIBCPS), a neurodevelopmental disorder first described in 2018, is caused by heterozygous pathogenic variants in CHD3. Its encoded protein plays a crucial role in the development of the nervous system of embryos. While phenotypic traits have been broadly defined (i.e. global neurodevelopmental delays such as intellectual disabilities and delayed speech acquisition, and physical features such as characteristic facial features and macrocephaly), the phenotypic spectrum has not been further assessed. We present the neurobehavioral profile of 38 individuals with variants in CHD3 and compare it to the ones of autism spectrum disorder (ASD) and Fragile X syndrome (FXS) cohorts. Profound clinical deficits were found in adaptive functioning, communication skills and sensorimotor functioning in most SNIBCPS participants. Similarities between FXS and SNIBCPS cohorts were unveiled, characterized by diminished levels of global adaptive behaviour and adaptive functioning in the social and communication domains. Nevertheless, despite profound challenges in global adaptive behavior in SNIBCPS, we reveal the social domain as showing the highest adaptive levels alongside minimal emotional/behavioural issues within the sample, suggesting relative strengths inherent to SNIBCPS. This study enriches the scarce SNIBCPS literature by delineating the neurobehavioral phenotypic spectrum of SNIBCPS and by innovating comparisons with clinically akin neurodevelopmental disorders.
Ligand-Restricted Strategy for Synthesizing Highly Pairing Dual Atom Catalysts
Authors: Wu Limin , Ma Yanfu , Liu Shuhui , Shi Ke , Li Wenyi , Mao Jianing , Zhao Wantong , Shan Jieqiong , Zhao Yang , Jiang Zheng , Zhang Riguang , Gao Rui , Liu Wei , Lu Gaoqing , Liu Jian
Published: February 2025

Dual atom catalysts (DACs), characterized by high activity and metal utilization, as well as structural diversity with a large variety of catalytic sites, hold immense promise for energy conversion technologies, garnering substantial interest from both academia and industry. However, achieving precise control and manipulation of atomic dispersion, pairing ratios, and interatomic distances in DACs, which significantly affect their multifunctional catalytic properties, remains a significant challenge. Herein, we developed a ligand-restricted strategy for the precise synthesis of highly pairing DACs with tunable atomic distances. This was accomplished by coordinating diamine ligands with dual metal precursors, restricting the pairing and relative positions of two metal atoms on two-dimensional graphitic carbon nitride. The atomic pairing ratio exceeded 82%, with the chain length of diamine molecules effectively regulating the distance between paired atoms. As a demonstration, the pairing Pt1-Au1 DACs exhibited almost three times catalytic activity for nitrate reduction to ammonia compared to their unpaired counterparts. Furthermore, shorter distanced Pt1-Au1 DAC reveals four times activity in photothermal catalyzed hydrogenation reactions than longer ones. This work not only introduces a novel design strategy for the atomic-scale fabrication of complex catalysts but also provides valuable insights into nanoscale reaction mechanisms in heterogeneous catalysis.
Quantitative analysis of tumor perfusion via contrast-enhanced ultrasound to predict the neoadjuvant chemotherapy efficacy for children with hepatoblastoma
Authors: Chen Meixi , Wang Yuanqi , Chen Yingqian , Jiang Hong , Xie Xiaoyan , Wang Xiaoli , Zhou Wenying , Huang Guangliang , Zhou Luyao
Published: February 2025

Background
Predicting the neoadjuvant chemotherapy efficacy may help choose appropriate treatment strategy of hepatoblastoma. Quantitative analysis of contrast-enhanced ultrasound (CEUS) has been used to predict the chemotherapy efficacy in various types of tumors, but its value in hepatoblastoma has not been fully evaluated.
Objective
To explore the value of quantitative analysis of CEUS in predicting the neoadjuvant chemotherapy efficacy for hepatoblastoma.
Materials and methods
Thirty-five hepatoblastoma patients who require neoadjuvant chemotherapy and underwent liver CEUS in our hospital from January 2017 to July 2023 were enrolled. A CEUS examination was performed at baseline, and perfusion parameters were obtained via perfusion quantification software. Patients were classified into responder group and non-responder group after 2 courses. The differences in quantitative parameters between two groups were compared.
Results
The MeanLin ratio (1.7 vs. 0.6 and 1.7 vs. 0.8), PE ratio (1.8 vs. 0.9 and 1.9 vs. 0.9), WiAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.6), WiPI ratio (1.9 vs. 0.8 and 2.0 vs. 0.9), WoAUC ratio (1.3 vs. 0.5 and 1.3 vs. 0.7), and WiWoAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.7) in the response group were significantly higher than those in the non-response group (all p < 0.05); when tumor’s region of interest was the active area, the WiR ratio (3.1 vs. 1.4) of the responder group was significantly higher (p = 0.04). The proportion of lesions with liquefaction necrosis before chemotherapy was significantly higher in the response group (p = 0.049).
Conclusion
Quantitative analysis of CEUS may have the potential to predict the neoadjuvant chemotherapy efficacy for hepatoblastoma.
E-Learning as an Alternative to Face-to-Face Teaching in Postgraduate Medical Education in a Resource-Limited Setting: Lessons from the COVID- 19 Pandemic – Experience from a Tertiary Teaching Hospital in Ethiopia
Authors: Petros Adane , Gebremariam Tewodros Haile , Kotiso Kehabtimer Shiferaw , Fikadu Chala , Gemechu Fitsum A. , Seifu Abiy , Kebede Meskerem Aleka , Endris Bilal Shikur , Hagos Seifu , Aklilu Tesfamariam , Yifter Helen , Demissie Hanna , Debebe Tequam , Wondimagegn Dawit
Published: February 2025

Background
The need for applying physical distancing in the era of COVID-19 greatly hampered conventional face-to-face classroom teaching. This necessitated the incorporation of electronic learning (E-learning) in postgraduate medical education to ensure training continuity of residency programs. However, the perception of medical residents towards this new E-learning approach is not well studied. We assessed the perceived satisfaction of residents and the barriers to implementing E-learning in postgraduate medical education.
Methods
We conducted a cross-sectional study from July 1 to December 30, 2020, among 200 residents from the departments of Internal Medicine, Surgery, Orthopedics, Neurology, and Obstetrics andGynecology (OBGYN) at the School of Medicine of Addis Ababa University. Self-administered questionnaires were used tocollect data on perception of E-learning and factors that affected it. Data were entered using Epidata and analyzed using Stata 14.0. Factor analysis determined 21 items from six components explained 65% of data variation. Multivariable logistic regression analysis was fitted to identify factors associated with the six components of satisfaction.
Results
Among the 200 participants, 71.5% were male; 35.5% and 29.5% were from the Surgery and Internal Medicine departments, respectively. The median age of the participants was29 years. Only 24% of the participants had prior E-learning experience before the pandemic, and 15.5% reported spending > 10% of their salary to access the internet for academic purposes. About half (51.5%) of the participants reported satisfaction with E-learning, and 43% supported that E-learning improved teacher-learner collaboration. Satisfaction with E-learning was less among Surgery and OBGYN residents compared to residents from Internal Medicine [AOR:0.3;95% CI 0.11–0.85] and [AOR:0.1;95% CI 0.03–0.4], respectively. In addition, high internet cost, using a mobile device for internet access, poor computer skills, and lack of prior E-learning exposure were all negatively associated with perceived E-learning experience
Conclusion
Experiences of residents and their perceptions on E-learning were mixed. E-learning as a substitute to face-to-face classroom learning was unpopular especially among Surgery and OBGYN residents. Several barriers to E-learning were identified. We recommend university departments to tailor E-learning teaching methods and interventions and improve infrastructure and resident computer skills to enhance current E-learning experiences.
Clinical Trial Number: Not Applicable