bluuebunny/crossref_metadata_2025 huggingface dataset:
Early structural connectivity within the sensorimotor network: Deviations related to prematurity and association to neurodevelopmental outcome
Authors: Neumane Sara , Gondova Andrea , Leprince Yann , Hertz-Pannier Lucie , Arichi Tomoki , Dubois Jessica
Published: November 2022

Consisting of distributed and interconnected structures that interact through cortico-cortical connections and cortico-subcortical loops, the sensorimotor (SM) network undergoes rapid maturation during the perinatal period and is thus particularly vulnerable to preterm birth. However, the impact of prematurity on the development and integrity of the emerging SM connections and their relationship to later motor and global impairments are still poorly understood. In this study we aimed to explore to which extent the early microstructural maturation of SM white matter (WM) connections at term-equivalent age (TEA) is modulated by prematurity and related with neurodevelopmental outcome at 18 months corrected age. We analyzed 118 diffusion MRI datasets from the developing Human Connectome Project (dHCP) database: 59 preterm (PT) low-risk infants scanned near TEA and a control group of full-term (FT) neonates paired for age at MRI and sex. We delineated WM connections between the primary SM cortices (S1, M1 and paracentral region) and subcortical structures using probabilistic tractography, and evaluated their microstructure with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) models. To go beyond tract-specific univariate analyses, we computed a maturational distance related to prematurity based on the multi-parametric Mahalanobis distance of each PT infant relative to the FT group. Our results confirmed the presence of microstructural differences in SM tracts between PT and FT infants, with effects increasing with lower gestational age at birth. Maturational distance analyses highlighted that prematurity has a differential effect on SM tracts with higher distances and thus impact on (i) cortico-cortical than cortico-subcortical connections; (ii) projections involving S1 than M1 and paracentral region; and (iii) the most rostral cortico-subcortical tracts, involving the lenticular nucleus. These different alterations at TEA suggested that vulnerability follows a specific pattern coherent with the established WM caudo-rostral progression of maturation. Finally, we highlighted some relationships between NODDI-derived maturational distances of specific tracts and fine motor and cognitive outcomes at 18 months. As a whole, our results expand understanding of the significant impact of premature birth and early alterations on the emerging SM network even in low-risk infants, with possible relationship with neurodevelopmental outcomes. This encourages further exploration of these potential neuroimaging markers for prediction of neurodevelopmental disorders, with special interest for subtle neuromotor impairments frequently observed in preterm-born children.
Spectacles with highly aspherical lenslets for myopia control do not change visual sensitivity in automated static perimetry
Authors: Gao Yi , Spiegel Daniel P. , Muzahid Izzah Al Ilma , Lim Ee Woon , Drobe Björn
Published: November 2022

Purpose

Spectacle lenses with arrays of lenslets have gained popularity in myopia control due to their high efficacy, low impact on visual performance, and non-invasiveness. One of the questions regarding their impact on visual performance that still remain is that: do the lenslets impact visual field sensitivity? The current study aims to investigate the impact of wearing spectacle lenses with highly aspherical lenslets (HAL) on the visual field sensitivity.

Methods

An automated static perimetry test (Goldman perimeter target III) was employed to measure the detection sensitivity in the visual field. Targets were white light dots of various luminance levels and size 0.43°, randomly appearing at 76 locations within 30° eccentricity. Twenty-one adult subjects (age 23–61, spherical equivalent refractive error (SER) −8.75 D to +0.88 D) participated in the study. Sensitivities through two lenses, HAL and a single vision lens (SVL) as the control condition, were measured in random order.

Results

The mean sensitivity differences between HAL and SVL across the 76 tested locations ranged between −1.14 decibels (dB) and 1.28 dB. Only one location at 30° in the temporal visual field reached statistical significance (p < 0.00065) whereby the sensitivity increased by 1.1 dB with HAL. No significant correlation was found between the difference in sensitivity and age or SER. Such a difference is unlikely to be clinically relevant.

Conclusion

Compared to the SVL, the HAL did not change detection sensitivity to static targets in the whole visual field within 30° eccentricity.
The effect of fiber supplementation on the prevention of diarrhea in hospitalized patients receiving enteral nutrition: A meta-analysis of randomized controlled trials with the GRADE assessment
Authors: Kaewdech Apichat , Sripongpun Pimsiri , Wetwittayakhlang Panu , Churuangsuk Chaitong
Published: November 2022

Introduction

Enteral nutrition (EN) in hospitalized patients has several advantages. However, post-feeding diarrhea occurs frequently and has been linked to negative outcomes. The EN formula itself may have an impact on how diarrhea develops, and fiber supplements may theoretically help patients experience less diarrhea. This study aimed to thoroughly evaluate whether adding fiber to EN decreases the likelihood of developing diarrhea and whether different types of fibers pose different effects on diarrhea (PROSPERO CRD 42021279971).

Methods

We conducted a meta-analysis on fiber supplementation in hospitalized adult patients receiving EN. We thoroughly searched PubMed, Medline, Embase, Scopus, Web of Science, CENTRAL, and ClinicalTrials.gov databases from inception to 1 September 2022. Only randomized controlled trials (RCTs) were included. Pooled results on the incidence of diarrhea were calculated using a random-effects model. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was applied. Only fiber types from soy polysaccharides (n = 4), psyllium (n = 3), mixed soluble/insoluble fiber (mixed fiber, n = 3), pectin (n = 2), and partially hydrolyzed guar gum (PHGG, n = 2) were examined in the sensitivity analysis.

Results

Among the 4,469 titles found, a total of 16 RCTs were included. Overall, compared to fiber-free formulas, fiber supplementation reduced the occurrence of diarrhea in patients receiving EN by 36% (pooled risk ratio [RR] of 0.64 [95% confidence interval (CI): 0.49–0.82, p = 0.005; I2 = 45%]), with GRADE showing the evidence of moderate certainty. Only mixed fiber and PHGG significantly decreased the incidence of diarrhea according to the sensitivity analyses for fiber types (RR 0.54, 95%CI: 0.39–0.75, I2 = 0% and RR 0.47, 95%CI: 0.27–0.83, I2 = 0%, respectively). The results for the remaining fiber types were unclear.

Conclusion

According to a meta-analysis, fiber supplements help lessen post-feeding diarrhea in hospitalized patients receiving EN. However, not all fiber types produced successful outcomes. Diarrhea was significantly reduced by PHGG and mixed soluble/insoluble fiber.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=279971, identifier: PROSPERO CRD 42021279971.
The characterization of tumor microenvironment infiltration and the construction of predictive index based on cuproptosis-related gene in primary lung adenocarcinoma
Authors: Li Kun , Wu Lei-Lei , Wang Hui , Cheng Hao , Zhuo Hui-Min , Hao Yun , Liu Zhi-Yuan , Li Chong-Wu , Qian Jia-Yi , Li Zhi-Xin , Xie Dong , Chen Chang
Published: November 2022

Objective

We aimed to use the cancer genome atlas and gene expression omnibus databases to explore the characterization of tumor microenvironment (TME) infiltration and construct a predictive index of prognosis and treatment effect based on cuproptosis-related genes (CRGs) in primary lung adenocarcinoma (LUAD).

Methods

We described the alterations of CRGs in 954 LUAD samples from genetic and transcriptional fields and evaluated their expression patterns from three independent datasets. We identified two distinct molecular subtypes and found that multi-layer CRG alterations were correlated with patient clinicopathological features, prognosis, and TME cell infiltrating characteristics. Then, a cuproptosis scoring system (CSS) for predicting the prognosis was constructed, and its predictive capability in LUAD patients was validated.

Results

Two molecular subtypes of cuproptosis (Copper Genes cluster A and cluster B) in LUAD were identified. Copper Genes cluster B had better survival than those with Copper Genes cluster A (p <0.01). Besides, we found that the infiltration of activated CD4+ T cells, natural killer T cells, and neutrophils was stronger in cluster A than in cluster B. Then, we constructed a highly accurate CSS to predict the prognosis, targeted therapy effect, and immune response. Compared with the low-CSS subgroup, the mutations of the TP53, MUC16, and TTN genes were more common in the high-CSS subgroup, while the mutation of TP53, TTN, and CSMD3 genes were more common in the low-CSS subgroup than in high-CSS subgroup. The low-score CSS group had an inferior survival than high-score CSS group (p <0.01). In addition, CSS presented good ability to predict the immune response (area under curve [AUC], 0.726). Moreover, AZD5363 and AZD8186 were the inhibitors of AKT and PI3K, respectively, and had lower IC50 and AUC in the low-score CSS group than it in the high-score CSS group.

Conclusions

CRGs are associated with the development, TME, and prognosis of LUAD. Besides, a scoring system based on CRGs can predict the efficacy of targeted drugs and immune response. These findings may improve our understanding of CRGs in LUAD and pave a new path for the assessment of prognosis and the development of more effective targeted therapy and immunotherapy strategies.
PPA1, an energy metabolism initiator, plays an important role in the progression of malignant tumors
Authors: Wang Shuying , Wei Jianmei , Li Shunwei , Luo Yuyin , Li Yifei , Wang Xianglin , Shen Wenzhi , Luo Dehong , Liu Daishun
Published: November 2022

Inorganic pyrophosphatase (PPA1) encoded by PPA1 gene belongs to Soluble Pyrophosphatases (PPase) family and is expressed widely in various tissues of Homo sapiens, as well as significantly in a variety of malignancies. The hydrolysis of inorganic pyrophosphate (PPi) to produce orthophosphate (Pi) not only dissipates the negative effects of PPi accumulation, but the energy released by this process also serves as a substitute for ATP. PPA1 is highly expressed in a variety of tumors and is involved in proliferation, invasion, and metastasis during tumor development, through the JNK/p53, Wnt/β-catenin, and PI3K/AKT/GSK-3β signaling pathways. Because of its remarkable role in tumor development, PPA1 may serve as a biological target for adjuvant therapy of tumor malignancies. Further, PPA1 is a potential biomarker to predict survival in patients with cancer, where the assessment of its transcriptional regulation can provide an in-depth understanding. Herein, we describe the signaling pathways through which PPA1 regulates malignant tumor progression and provide new insights to establish PPA1 as a biomarker for tumor diagnosis.
The risk of osteoporotic fractures after gastrectomy: Findings from the Korean national sample cohort database (2002-2019)
Authors: Yun Il , Hurh Kyungduk , Jeong Sung Hoon , Park Eun-Cheol , Jang Sung-In
Published: November 2022

Objective

This study used a national sample cohort database to investigate the risk of osteoporotic fractures after gastrectomy is performed for gastric cancer.

Materials and Methods

We used data from the Korea National Health Insurance Service-National Sample Cohort between 2002 and 2019. After performing 1:3 propensity score matching, 28,328 individuals were analysed in the final study (7, 082 cases; 21, 246 controls). Gastrectomy data were extracted from the coded claims data, and osteoporotic fractures were defined as the occurrence of fractures in any of the vertebrae, distal radius, humerus, or hip, according to the 10th version of the International Classification of Diseases. A Cox proportional hazards regression model was generated to investigate the association between gastrectomy and risk of osteoporotic fractures.

Results

Patients with gastric cancer who underwent a gastrectomy had a higher risk of osteoporotic fractures as compared to the general population (men, hazard ratio [HR]: 1.13, 95% confidence interval [CI]: 1.00-1.27; women, HR: 1.18, 95% CI: 1.06-1.30). A significantly higher risk of osteoporotic fractures was observed with surgical resection than with endoscopic resection (men, surgical, HR: 1.28, 95% CI: 1.08-1.52, endoscopic, HR: 1.04, 95% CI: 0.90-1.21; women, surgical, HR: 1.34, 95% CI: 1.11-1.62, endoscopic, HR: 1.13, 95% CI: 1.01-1.27). In men, the risk of hip fracture was the highest among the four fracture sites (HR: 1.18, 95% CI:0.89-1.56), while in women, the risk of vertebral fracture after gastrectomy was the highest (HR: 1.16, 95% CI: 0.99-1.35).

Conclusion

Patients with gastric cancer who underwent gastrectomy had a higher risk of osteoporotic fractures as compared to the general population. This suggests the need for bone metabolism management in patients with gastric cancer to prevent post-gastrectomy complications.
KIAA1429 regulates alternative splicing events of cancer-related genes in hepatocellular carcinoma
Authors: Liu Zhao-chen , Li Lu-Hao , Li Ding-Yang , Gao Zhi-Qiang , Chen Dong , Song Bin , Jiang Bing-Hua , Dang Xiao-wei
Published: November 2022

Hepatocellular carcinoma (HCC) remains one of the most fatal malignancies with high morbidity and mortality rates in the world, whose molecular pathogenesis is incompletely understood. As an RNA-binding protein participating in the processing and modification of RNA, KIAA1429 has been proved to be implicated in the pathogenesis of multiple cancers. However, how KIAA1429 functions in alternative splicing is not fully reported. In the current study, multi-omics sequencing data were used to analyze and decipher the molecular functions and the underlying mechanisms of KIAA1429 in HCC samples. RNA sequencing data (RNA-seq) analysis demonstrated that in HCCLM3 cells, alternative splicing (AS) profiles were mediated by KIAA1429. Regulated AS genes (RASGs) by KIAA1429 were enriched in cell cycle and apoptosis-associated pathways. Furthermore, by integrating the RNA immunoprecipitation and sequencing data (RIP-seq) of KIAA1429, we found that KIAA1429-bound transcripts were highly overlapping with RASGs, indicating that KIAA1429 could globally regulate the alternative splicing perhaps by binding to their transcripts in HCCLM3 cells. The overlapping RASGs were also clustered in cell cycle and apoptosis-associated pathways. In particular, we validated the regulated AS events of three genes using clinical specimens from HCC patients, including the exon 6 of BPTF gene and a marker gene of HCC. In summary, our results shed light on the regulatory functions of KIAA1429 in the splicing process of pre-mRNA and provide theoretical basis for the targeted therapy of HCC.
Efficacy and safety of transarterial chemoembolization plus antiangiogenic- targeted therapy and immune checkpoint inhibitors for unresectable hepatocellular carcinoma with portal vein tumor thrombus in the real world
Authors: Feng Jin-Kai , Liu Zong-Han , Fu Zhi-Gang , Chai Zong-Tao , Sun Ju-Xian , Wang Kang , Cheng Yu-Qiang , Zhu Hong-Fei , Xiang Yan-Jun , Zhou Li-Ping , Shi Jie , Guo Wei-Xing , Zhai Jian , Cheng Shu-Qun
Published: November 2022

Purpose

This study aimed to assess the efficacy and safety of a triple therapy that comprises transarterial chemoembolization (TACE), antiangiogenic-targeted therapy, and programmed death-1 (PD-1) inhibitors in a real-world cohort of patients with unresectable hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).

Methods

Consecutive patients treated with TACE combined with antiangiogenic therapy and PD-1 inhibitors at the Eastern Hepatobiliary Surgery Hospital between June 2019 and May 2021 were enrolled. The baseline characteristics and treatment course of the patients were recorded. The tumor response was evaluated based on the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and HCC-specific modified RECIST (mRECIST). The overall survival (OS) and progression-free survival (PFS) of the patients were analyzed using the Kaplan–Meier method. Adverse events (AEs) were assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.

Results

As of the data cutoff on 30 August 2021, the median follow-up time was 10.0 (3.9–28.4) months. A total of 39 eligible patients were included. The objective response rate (ORR) and the disease control rate (DCR) were 35.9% and 74.4% according to the RECIST 1.1, and 48.7% and 84.6% according to mRECIST criteria, respectively. The median OS and PFS were 14.0 and 9.2 months, respectively. Moreover, 34 (87.2%) patients experienced at least one treatment-related AE and 8 (20.5%) patients experienced grade 3/4 treatment-related AEs. The most common treatment- and laboratory-related AEs were hypertension (46.2%) and decreased albumin (53.8%), respectively. No treatment-related mortality occurred during the study period.

Conclusions

TACE combined with antiangiogenic-targeted therapy and immune checkpoint inhibitors may have promising anticancer activity in unresectable HCC patients with PVTT. AEs were manageable, with no unexpected overlapping toxicities.
In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts
Authors: Passeri Thibault , Dahmani Ahmed , Masliah-Planchon Julien , El Botty Rania , Courtois Laura , Vacher Sophie , Marangoni Elisabetta , Nemati Fariba , Roman-Roman Sergio , Adle-Biassette Homa , Mammar Hamid , Froelich Sébastien , Bièche Ivan , Decaudin Didier
Published: November 2022

Background

Management of advanced chordomas remains delicate considering their insensitivity to chemotherapy. Homozygous deletion of the regulatory gene CDKN2A has been described as the most frequent genetic alteration in chordomas and may be considered as a potential theranostic marker. Here, we evaluated the tumor efficacy of the CDK4/6 inhibitor palbociclib, as well as the PLK1 inhibitor volasertib, in three chordoma patient-derived xenograft (PDX) models to validate and identify novel therapeutic approaches.

Methods

From our chordoma xenograft panel, we selected three models, two of them harboring a homozygous deletion of CDKN2A/2B genes, and the last one a PBRM1 pathogenic variant (as control). For each model, we tested the palbociclib and volasertib drugs with pharmacodynamic studies together with RT-PCR and RNAseq analyses.

Results

For palbociclib, we observed a significant tumor response for one of two models harboring the deletion of CDKN2A/2B (p = 0.02), and no significant tumor response in the PBRM1-mutated PDX; for volasertib, we did not observe any response in the three tested models. RT-PCR and RNAseq analyses showed a correlation between cell cycle markers and responses to palbociclib; finally, RNAseq analyses showed a natural enrichment of the oxidative phosphorylation genes (OxPhos) in the palbociclib-resistant PDX (p = 0.02).

Conclusion

CDK4/6 inhibition appears as a promising strategy to manage advanced chordomas harboring a loss of CDKN2A/2B. However, further preclinical studies are strongly requested to confirm it and to understand acquired or de novo resistance to palbociclib, in the peculiar view of a targeting of the oxidative phosphorylation genes.
Apolipoproteins: New players in cancers
Authors: He Yingcheng , Chen Jianrui , Ma Yanbing , Chen Hongping
Published: November 2022

Apolipoproteins (APOs), the primary protein moiety of lipoproteins, are known for their crucial role in lipid traffic and metabolism. Despite extensive exploration of APOs in cardiovascular diseases, their roles in cancers did not attract enough attention. Recently, research focusing on the roles of APOs in cancers has flourished. Multiple studies demonstrate the interaction of APOs with classical pathways of tumorigenesis. Besides, the dysregulation of APOs may indicate cancer occurrence and progression, thus serving as potential biomarkers for cancer patients. Herein, we summarize the mechanisms of APOs involved in the development of various cancers, their applications as cancer biomarkers and their genetic polymorphism associated with cancer risk. Additionally, we also discuss the potential anti-cancer therapies by virtue of APOs. The comprehensive review of APOs in cancers may advance the understanding of the roles of APOs in cancers and their potential mechanisms. We hope that it will provide novel clues and new therapeutic strategies for cancers.
Combining beams in different locations for aerospace defense in a turbulent atmosphere
Authors: Liao Kangjie , Liu Zhiwei , Chu Xiuxiang
Published: November 2022

A fixed high-power laser system used as an aerospace defense weapon has limitations such as the transmitter size, serious thermal blooming during propagation, rapid motion, and the variation of the location of the target. In the present paper, we propose a method by arranging many high-power systems with adequate distance in a defense area. The intensity distribution and the energy irradiated on the target are studied and compared with a fixed laser system. Results show that adequate arrangement of many high-power laser systems can reply to the arbitrary and rapid motion of the target.
Storage of packed red blood cells impairs an inherent coagulation property of erythrocytes
Authors: Öhlinger Thomas , Müllner Ernst W. , Fritz Magdalena , Werning Maike , Baron-Stefaniak Joanna , Jungbauer Christof , Baron David M. , Salzer Ulrich
Published: November 2022

Storage of packed red blood cells is associated with changes in erythrocytes that over time increasingly impair cellular function and potentially contribute to adverse effects associated with blood transfusion. Exposure of phosphatidylserine at the outer membrane leaflet of erythrocytes and shedding of microvesicles (MVs) during packed red blood cell storage are alterations assumed to increase the risk of prothrombotic events in recipients. Here, we used rotational thromboelastometry to study the coagulation process in blood samples with erythrocytes from stored PRBCs reconstituted with freshly prepared platelet-rich plasma. We explored the influence of following effects on the coagulation process: 1) PRBC storage duration, 2) differences between erythrocytes from stored PRBCs compared to freshly drawn erythrocytes, and 3) the contribution of added MVs. Interestingly, despite of a higher fraction of PS-positive cells, erythrocytes from PRBCs stored for 6 weeks revealed longer clotting times than samples with erythrocytes stored for 2 or 4 weeks. Further, clotting times and clot formation times were considerably increased in samples reconstituted with erythrocytes from stored PRBCs as compared to fresh erythrocytes. Moreover, MVs added to reconstituted samples elicited only comparably small and ambiguous effects on coagulation. Thus, this study provides no evidence for an amplified clotting process from prolonged storage of PRBCs but on the contrary implicates a loss of function, which may be of clinical significance in massive transfusion. Our observations add to the increasing body of evidence viewing erythrocytes as active players in the clotting process.
Sustainable strategies for management of the “false root-knot nematode” Nacobbus spp.
Authors: Lax Paola , Passone María A. , Becerra Alejandra G. , Sosa Ana L. , Ciancio Aurelio , Finetti-Sialer Mariella M , Rosso Laura C.
Published: November 2022

The genusNacobbus, known as the false root-knot nematode, is native to the American continent and comprises polyphagous species adapted to a wide range of climatic conditions. Alone or in combination with other biotic and abiotic factors,Nacobbusspp. can cause significant economic yield losses on main food crops such as potato, sugar beet, tomato, pepper and bean, in South and North America. Although the genus distribution is restricted to the American continent, it has quarantine importance and is subject to international legislation to prevent its spread to other regions, such as the European Union. The management ofNacobbusspp. remains unsatisfactory due to the lack of information related to different aspects of its life cycle, survival stages in the soil and in plant material, a rapid and reliable diagnostic method for its detection and the insufficient source of resistant plant genotypes. Due to the high toxicity of chemical nematicides, the search for alternatives has been intensified. Therefore, this review reports findings on the application of environmentally benign treatments to manageNacobbusspp. Biological control strategies, such as the use of different organisms (mainly bacteria, fungi and entomopathogenic nematodes) and other eco-compatible approaches (such as metabolites, essential oils, plant extracts, phytohormones and amendments), either alone or as part of a combined control strategy, are discussed. Knowledge of potential sources of resistance for genetic improvement for crops susceptible toNacobbusspp. are also reported. The sustainable strategies outlined here offer immediate benefits, not only to counter the pathogen, but also as good alternatives to improve crop health and growth.
Constructing a critical thinking evaluation framework for college students majoring in the humanities
Authors: Li Suqi , Tang Shenyu , Geng Xingyu , Liu Qi
Published: November 2022

Introduction

Education for sustainable development (ESD) has focused on the promotion of sustainable thinking skills, capacities, or abilities for learners of different educational stages. Critical thinking (CT) plays an important role in the lifelong development of college students, which is also one of the key competencies in ESD. The development of a valuable framework for assessing college students’ CT is important for understanding their level of CT. Therefore, this study aimed to construct a reliable self-evaluation CT framework for college students majoring in the humanities.

Methods

Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and Item analysis were conducted to explore the reliability and validity of the CT evaluation framework. Six hundred and forty-two college students majoring in the humanities were collected. The sample was randomly divided into two subsamples (n1 = 321, n2 = 321).

Results

The Cronbach’s alpha coefficient for the whole scale was 0.909, and the values of the Cronbach’s alpha coefficients for individual factors of the scale ranged from 0.724 to 0.878. Then CFA was conducted within the scope of the validity study of the scale. In this way, the structure of the 7-factor scale was confirmed. Results indicated that the constructed evaluation framework performed consistently with the collected data. CFA also confirmed a good model fitting of the relevant 22 factors of the college students’ CT framework (χ2/df = 3.110, RMSEA = 0.056, GFI = 0.927, AGFI = 0.902, NFI = 0.923, and CFI = 0.946).

Discussion

These findings revealed that the CT abilities self-evaluation scale was a valid and reliable instrument for measuring the CT abilities of college students in the humanities. Therefore, the college students’ CT self-evaluation framework included three dimensions: discipline cognition (DC), CT disposition, and CT skills. Among them, CT disposition consisted of motivation (MO), attention (AT), and open-mindedness (OM), while CT skills included clarification skills (CS), organization skills (OS), and reflection (RE). Therefore, this framework can be an effective instrument to support college students’ CT measurement. Consequently, some suggestions are also put forward regarding how to apply the instrument in future studies.
Research on value co-creation mechanism of platform enterprises in digital innovation ecosystem: A case study on Haier HOPE platform in China
Authors: Li Yuhua , Fu Kaiwen , Gong Xiheng , Xiang Ziwei , Zhang Jingyi , Liao Chengjun
Published: November 2022

Digital technology has given the innovation subject a new way of value creation, expanded the existing innovation ecosystem theory, and triggered scholars’ in-depth thinking on the digital innovation ecosystem. Based on the event system theory and taking Haier’s hope platform as a vertical case study, this paper deeply explores the research mechanism of value creation of platform enterprises in the digital innovation ecosystem, and reveals the role and impact of digital innovation ability, openness, and business innovation model on the process of co-creation. The research results show that: in the open connection stage, the platform solves the problem of weakening the advantages of the platform, and improves the innovation efficiency of enterprises by continuously improving the digital innovation ability; in the interactive and iterative stage, the platform carries out open innovation, breaks through the difficulties of platform expansion, and realizes the benign expansion of the platform. In the co-creation stage, the user experience is blocked, and the platform adopts the platform community business model to connect the user relationship and improve the user experience. In the digital innovation ecosystem, platform enterprises gradually form self-organization and self-circulation value co-creation through internal self-construction and external cooperation, and form a data-driven co-creation model.
The Yale Food Addiction Scale 2.0 and the modified Yale Food Addiction Scale 2.0 in Taiwan: Factor structure and concurrent validity
Authors: Chen I-Hua , Huang Po-Ching , Lin Yi-Ching , Gan Wan Ying , Fan Chia-Wei , Yang Wen-Chi , Tung Serene En Hui , Poon Wai Chuen , Griffiths Mark D. , Lin Chung-Ying
Published: November 2022

Introduction

The most widely used instruments to assess food addiction – the Yale Food Addiction Scale 2.0 (YFAS 2.0) and its modified version (mYFAS 2.0) – have not been validated in a Taiwanese population. The present study compared the psychometric properties between the Taiwan versions of YFAS 2.0 and mYFAS 2.0 among university students.

Methods

An online survey comprising the YFAS 2.0, mYFAS 2.0, Weight Self-Stigma Questionnaire (WSSQ) and International Physical Activity Questionnaire-Short Form (IPAQ-SF) were used to assess food addiction, self-stigma, and physical activity.

Results

All participants (n= 687; mean age = 24.00 years [SD ± 4.48 years]; 407 females [59.2%]) completed the entire survey at baseline and then completed the YFAS 2.0 and mYFAS 2.0 again three months later. The results of confirmatory factor analysis (CFA) indicated that the YFAS 2.0 and mYFAS 2.0 both shared a similar single-factor solution. In addition, both the YFAS 2.0 and mYFAS 2.0 reported good internal consistency (Cronbach’s α = 0.90 and 0.89), good test-retest reliability (ICC = 0.71 and 0.69), and good concurrent validity with the total scores being strongly associated with the WSSQ (r= 0.54 and 0.57;p< 0.01), and less strongly associated with BMI (r= 0.17 and 0.13;p< 0.01) and IPAQ-SF (r= 0.23 and 0.25;p< 0.01).

Discussion

Based on the findings, the Taiwan versions of the YFAS 2.0 and mYFAS 2.0 appear to be valid and reliable instruments assessing food addiction.
Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor
Authors: Abebe Endeshaw Chekol , Mengstie Misganaw Asmamaw , Seid Mohammed Abdu , Dejenie Tadesse Asmamaw
Published: November 2022

Alarin is a pleiotropic peptide involved in a multitude of putative biological activities, notably, it has a regulatory effect on depression-like behaviors. Although further elucidating research is needed, animal-based cumulative evidence has shown the antidepressant-like effects of alarin. In light of its regulatory role in depression, alarin could be used as a promising antidepressant in future treatment for depression. Nevertheless, the available information is still insufficient and the therapeutic relevance of alarin in depression is still of concern. Moreover, a plethora of studies have reported that the actions of alarin, including antidepressant activities, are mediated by a separate yet unidentified receptor, highlighting the need for more extensive research. This review focuses on the current understanding of the regulatory effects and future therapeutic relevance of alarin on depression, and the arguments on its receptors.
What evidence is there for implicating the brain orexin system in neuropsychiatric symptoms in dementia?
Authors: Bergamini Giorgio , Coloma Preciosa , Massinet Helene , Steiner Michel Alexander
Published: November 2022

Neuropsychiatric symptoms (NPS) affect people with dementia (PwD) almost universally across all stages of the disease, and regardless of its exact etiology. NPS lead to disability and reduced quality of life of PwD and their caregivers. NPS include hyperactivity (agitation and irritability), affective problems (anxiety and depression), psychosis (delusions and hallucinations), apathy, and sleep disturbances. Preclinical studies have shown that the orexin neuropeptide system modulates arousal and a wide range of behaviors via a network of axons projecting from the hypothalamus throughout almost the entire brain to multiple, even distant, regions. Orexin neurons integrate different types of incoming information (e.g., metabolic, circadian, sensory, emotional) and convert them into the required behavioral output coupled to the necessary arousal status. Here we present an overview of the behavioral domains influenced by the orexin system that may be relevant for the expression of some critical NPS in PwD. We also hypothesize on the potential effects of pharmacological interference with the orexin system in the context of NPS in PwD.
To what extent can community energy mitigate energy poverty in Germany?
Authors: Bode Annika
Published: November 2022

The reduction of energy poverty and the expansion of citizen-led community energy projects are two important issues for a just energy transition in the European Union. While some socio-economic aspects of community energy are well researched, there is a dearth of literature on its potential to include vulnerable households and eventually reduce the risk of energy poverty. Through the lens of energy vulnerability thinking, this paper examines current and future drivers of energy poverty in Germany, as well as factors that may limit or facilitate the inclusion of vulnerable consumers in community energy. It draws on previous studies and on 12 semi-structured interviews conducted in the Summer of 2021 with experts in the fields of energy poverty or community energy. Using a three-tenet conceptualization of energy justice, the article argues that community energy projects can mitigate energy poverty in Germany by providing affordable renewable electricity to vulnerable and energy-poor consumers, as well as by establishing fair procedures that consider various vulnerability contexts. Yet, deep-rooted distributional injustices in housing and social transfer schemes that drive energy poverty are likely to remain. In order to advance energy justice, community energy projects hinge on a collaborative multi-level and multi-actor environment.
Ecosystem Restoration: What, Why, How, and Where?
Authors: Panter Connor T. , Baines Oliver , Draper Eve L. , Hunt Laura , Schrodt Franziska , Veeken Annegreet , Viner Charlotte E. , Field Richard
Published: November 2022

Our world contains many ecosystems, from tropical forests to coral reefs to urban parks. Ecosystems help us in important ways, including cleaning our air and water, storing carbon, and producing food. People have been shaping most ecosystems for at least 12,000 years. Human impact has become so intense that many ecosystems are now threatened. That is why the United Nations has decided that the next 10 years are the Decade on Ecosystem Restoration. But what is ecosystem restoration and how do we do it? In this article, we will tell you why ecosystem restoration is important and why it can be difficult. We will explain how it can be done well, and give examples from a range of projects. Successful restoration must include local people and requires lots of data. Restoration should not always return ecosystems back to what they were like once before.
Research using hashtags: A meta-synthesis
Authors: La Rocca Gevisa , Boccia Artieri Giovanni
Published: November 2022

In the last 20 years, research using hashtags has grown considerably. The changes that occurred in the digital environment have influenced their diffusion and development. Today, there is considerable research on hashtags, their use, and on hashtag activism. Likewise, there is a growing interest in their descriptive measures and their metrics. This article aimed to provide a review of this area of research and studies to outline the traits of hashtag research, which are yet nascent. To achieve this, we used a meta-study to produce a meta-synthesis capable of bringing out similarities and differences in research using hashtags and identifying spaces for the generation of new knowledge.
The agency of fertility plans
Authors: Bazzani Giacomo , Vignoli Daniele
Published: November 2022

Fertility plans are a prominent area for agency research, and are a clear example of a misalignment between resources and agency capacity. We relied both on the idea of conversion factors of the Capability Approach and the pragmatist tradition of temporal-oriented agency to propose a framework for the study of fertility agency as the conversion process of resources into plans and behavior. We outlined said framework by using a unique dataset on fertility plans composed of open and closed questions from an Italian sample. Economic factors and imaginaries related to children and family represented the vast majority of (hindering and enabling) conversion factors. The notion of conversion factors is crucial for disentangling the network of heterogeneous elements involved in fertility agency: it allows focus to be shifted from structural factors related to social position and psychological characteristics to more situated elements that enable agency capacity.
Socio-historical analysis of the social importance of pharmacovigilance
Authors: Coca Juan R. , Coca-Asensio Raquel , Esteban Bueno Gema
Published: November 2022

Pharmacovigilance is a scientific discipline that has changed a lot in recent years and is of great social importance. The case of the so-called sulfonamide elixir showed society the importance of this discipline. Since then, pharmacovigilance has evolved into a scientific discipline with a strong social character. In this paper, a historical review is made of several paradigmatic examples of this discipline to reflect on what pharmacovigilance could be like finally. We conclude that this discipline could be more closely related to other areas of the social sciences, which would help to promote a more democratic social environment taking into account the needs of individuals and social groups.
Integral definition and conceptual model of mental health: Proposal from a systematic review of different paradigms
Authors: Coronel-Santos Maday Alicia , Rodríguez-Macías Juan Carlos
Published: November 2022

Global society presents a mental health scenario characterized by the prevalence of mental disorders and the limited existence of formal care services. Faced with such a context, it is necessary to review what is understood and done in favor of mental health. This implies, in the first instance, analyzing the concept of mental health from a comprehensive approach that takes into account different perspectives from the social and natural sciences, related factors, and care options. Therefore, the present work aimed to propose an integral definition and a conceptual model of mental health based on the Systematic Literature Review, with the PRISMA approach, of the theoretical frameworks of 52 articles related to mental health published up to February 2022. A qualitative approach was used, with a Grounded Theory design, which allowed comparing different paradigms and identifying gaps in conceptual notions to build an explanatory model of mental health. The results showed three dominant paradigms that circumscribe the concept of mental health. Mental health is understood as the absence of illness, positive mental health, and a state of equilibrium. In addition, the need to propose a definition that integrates these dominant paradigms was mainly identified, and that would allow a broader understanding of the state of equilibrium as the basic process through which the individual must pass in the search for personal recovery. From the comparative analysis of the categories designated according to the Grounded Theory approach, an explanatory model was proposed to define mental health as the internal process of self-care, centered on the self-awareness and self-regulation of the human being, in which the person seeks to balance their feelings, thoughts, and behaviors, intrapersonal and interpersonal ones, to approach an optimal state of wellbeing and absence of mental disorders according to universal values and symptoms, and biological, social, psychological, and environmental factors.
PyThea: An open-source software package to perform 3D reconstruction of coronal mass ejections and shock waves
Authors: Kouloumvakos Athanasios , Rodríguez-García Laura , Gieseler Jan , Price Daniel J. , Vourlidas Angelos , Vainio Rami
Published: November 2022

PyThea is a newly developed open-source Python software package that provides tools to reconstruct coronal mass ejections (CMEs) and shocks waves in three dimensions, using multi-spacecraft remote-sensing observations. In this article, we introduce PyThea to the scientific community and provide an overview of the main functionality of the core software package and the web application. This package has been fully built in Python, with extensive use of libraries available within this language ecosystem. PyThea package provides a web application that can be used to reconstruct CMEs and shock waves. The application automatically retrieves and processes remote-sensing observations, and visualizes the imaging data that can be used for the analysis. Thanks to PyThea, the three-dimensional reconstruction of CMEs and shock waves is an easy task, with final products ready for publication. The package provides three widely used geometrical models for the reconstruction of CMEs and shocks, namely, the graduated cylindrical shell (GCS) and an ellipsoid/spheroid model. It also provides tools to process the final fittings and calculate the kinematics. The final fitting products can also be exported and reused at any time. The source code of PyThea package can be found in GitHub and Zenodo under the GNU General Public License v3.0. In this article, we present details for PyThea‘s python package structure and its core functionality, and we show how this can be used to perform three-dimensional reconstruction of coronal mass ejections and shock waves.
Influence of negative stereotype on physical activity level among older adults during a training session
Authors: Deshayes Maxime , Palermo Angèle , Korchi Karim , Philippe Antony G.
Published: November 2022

The present research examined the effect of a negative stereotype induction on older adults' physical activity level, measured objectively and subjectively. Twenty older adults (18 women and two men; Mage = 67.4, SDage = 4.4) were assigned to a control condition, a neutral condition and a negative stereotype condition during three separate visits (i.e., within-subject design). In each physical activity session, participants performed the same training. Objective physical activity level was the time spent at moderate to vigorous intensity measured by accelerometry and subjective physical activity level was measured with the RPE-session method. Inactivity time was also objectively assessed. Results revealed no effect of the different conditions on objective physical activity level, but subjective physical activity level and inactivity time were lower in the neutral condition and in the negative stereotype condition compared to the control condition. It was suggested that when a negative stereotype is induced, participants perceived the task as less intense compared to the control condition, which result in less inactivity time, suggesting that the negative stereotype had a positive influence on physical activity. Another interesting result was that effects were similar in the negative stereotype condition and in the neutral condition, revealing that the neutral condition might not be a control condition. While these results are not in line with the stereotype threat literature, they echo previous recent studies also showing a positive effect of a negative stereotype induction, calling into question the stereotype threat theory.
Production of pigments by Monascus ruber CCT0302 in culture media containing maltose as substrate
Authors: Oliveira Camila Fernanda Dias , Cardoso Lígia Alves da Costa , Vendruscolo Francielo
Published: November 2022

The aim of this study was to show how maltose production residues can be used to obtain natural pigments by Monascus ruber CCT 3802 in solid and submerged cultures. The microbial growth and the colour and heat stability characteristics of the pigments produced in both solid and submerged media, with different maltose syrup concentrations, were determined. The results showed that the addition of maltose provided significant increases in the velocity of microbial growth and production of red pigments. The highest radial growth velocity of Monascus ruber (0.1053 mm h−1) was obtained when cultivated in a medium containing 5 g L−1 of maltose syrup, corresponding to a 71.7% increase in growth as compared to the growth velocity in the control medium. Using submerged fermentation, the culture medium containing 10 g L−1 of maltose syrup provided the greatest concentrations of red pigments (14.54 AU510nm g−1 dry biomass) with an intense dark red colour, showing that Monascus ruber CCT 3802 had the capacity to assimilate the substrate and produce pigments. The red pigments produced in the cultures showed good heat stability with activation energies of 13.735 Kcal mol−1.