bluuebunny/crossref_metadata_2025 huggingface dataset:
Fast but Not Furious. When Sped Up Bit Rate of Information Drives Rule Induction
Authors: Radulescu Silvia , Kotsolakou Areti , Wijnen Frank , Avrutin Sergey , Grama Ileana
Published: November 2021

The language abilities of young and adult learners range from memorizing specific items to finding statistical regularities between them (item-bound generalization) and generalizing rules to novel instances (category-based generalization). Both external factors, such as input variability, and internal factors, such as cognitive limitations, have been shown to drive these abilities. However, the exact dynamics between these factors and circumstances under which rule induction emerges remain largely underspecified. Here, we extend our information-theoretic model (Radulescu et al., 2019), based on Shannon’s noisy-channel coding theory, which adds into the “formula” for rule induction the crucial dimension of time: the rate of encoding information by a time-sensitive mechanism. The goal of this study is to test the channel capacity-based hypothesis of our model: if the input entropy per second is higher than the maximum rate of information transmission (bits/second), which is determined by the channel capacity, the encoding method moves gradually from item-bound generalization to a more efficient category-based generalization, so as to avoid exceeding the channel capacity. We ran two artificial grammar experiments with adults, in which we sped up the bit rate of information transmission, crucially not by an arbitrary amount but by a factor calculated using the channel capacity formula on previous data. We found that increased bit rate of information transmission in a repetition-based XXY grammar drove the tendency of learners toward category-based generalization, as predicted by our model. Conversely, we found that increased bit rate of information transmission in complex non-adjacent dependency aXb grammar impeded the item-bound generalization of the specific a_b frames, and led to poorer learning, at least judging by our accuracy assessment method. This finding could show that, since increasing the bit rate of information precipitates a change from item-bound to category-based generalization, it impedes the item-bound generalization of the specific a_b frames, and that it facilitates category-based generalization both for the intervening Xs and possibly for a/b categories. Thus, sped up bit rate does not mean that an unrestrainedly increasing bit rate drives rule induction in any context, or grammar. Rather, it is the specific dynamics between the input entropy and the maximum rate of information transmission.
Study on Willingness to Pay and Impact Mechanism of Gutter Oil Treatment: Taking Urban Residents in Sichuan Province as an Example
Authors: Cheng Peng , Xinyu Liang , Sidai Guo , Yubing Qian
Published: November 2021

“Gutter oil” is a term for the practice of recycling used waste oil from restaurant fryers, sinks, and even slaughterhouses and sewers, and has been a major food safety and sanitation issue in China for many years. However, with proper treatment, these issues can be mitigated, turning large amounts of waste product into valuable resources and conserving energy resources. Based on this questionnaire survey conducted in the cities of Chengdu and Mianyang in Sichuan, China, this paper uses the value evaluation method to measure urban residents’ willingness to pay for the treatment of gutter oil, and explores the factors and path influencing residents’ willingness to pay based on the extended theory of planned behavior. The results of this study affirms the validity and universality of the Theory of Planned Behavior. Behavioral attitude, perceived behavioral control, and subjective norms have a direct positive impact on their willingness to pay. Risk perception and past experience indirectly affect residents’ willingness to pay for gutter oil through the intermediary variable of behavioral attitude, which means that the public’s risk awareness can be improved by vigorously publicizing the harmful effects of gutter oil, thereby also increasing acceptance toward gutter oil treatment. As an intermediary variable, subjective norms have a significant indirect effect on the impact path of past experience on willingness to pay, which reflects the significant influence of subjective norms such as reference group and environment. The results show that urban residents have a higher willingness to pay for the treatment of gutter oil. The mean willingness to pay is 7.75 RMB per month per capita.
Verb-Mediated Prediction in Bilingual Toddlers
Authors: Theimann Ane , Kuzmina Ekaterina , Hansen Pernille
Published: November 2021

Prediction is an important mechanism for efficient language processing. It has been shown that as a part of sentence processing, both children and adults predict nouns based on semantically constraining verbs. Language proficiency is said to modulate prediction: the higher proficiency, the better the predictive skill. Children growing up acquiring two languages are often more proficient in one of them, and as such, investigation of the predictive ability in young bilingual children can shed light on the role of language proficiency. Furthermore, according to production-based models, the language production system drives the predictive ability. The present study investigates whether bilingual toddlers predict upcoming nouns based on verb meanings in both their languages, and whether this ability is associated with expressive vocabulary. Seventeen Norwegian-English bilingual toddlers (aged 2;5–3;3), dominant in Norwegian, participated in the study. Verb-mediated predictive ability was measuredviaa visual world paradigm (VWP) experiment, including sentences with semantically constraining and neutral verbs. Expressive vocabulary was measured by MacArthur-Bates CDI II. The results suggested that the toddler group predicted upcoming noun arguments in both their dominant and non-dominant languages, but were faster in their dominant language. This finding highlights the importance of language dominance for predictive processing. There was no significant relationship between predictive ability and expressive vocabulary in either language.
Design and Implementation of Intelligent Learning System Based on Big Data and Artificial Intelligence
Authors: Yang Yawen
Published: November 2021

In order to improve the level of education development in remote areas of China, help minority schools to better play the advantages of multimedia network teaching resources provided by the state, and further improve the level of multimedia network management, a multimedia network teaching management system is studied and developed. The teaching information and business process of the school is analyzed, the division of the structure of the film and television multimedia information management system is completed, and the overall structure, functional structure, and database of the system are designed; Tornado technology, NoSQL database technology, jQuery technology, and Ajax technology are used to complete the development of the system. The results show that the real system can provide a highly automated platform for the school multimedia network-teaching management. The system makes the teaching staff work more efficiently and accurately. The results show that the system studied has a significant effect on the multimedia teaching of minority films and television. Using the characteristics of the combination of pictures, text, sound, image, and shadow, the knowledge can be shown to students intuitively, which is helpful to relaxed and happy learning of students and stimulate their desire to learn. Multimedia teaching has become an important teaching assistant tool. This exploration can provide theoretical support for the design of the network teaching information management system based on artificial intelligence, decentralize the complex network environment, and carry out decentralized management.
A Feasibility Study of the Addition of STEPPS in Outpatients With Bipolar Disorder and Comorbid Borderline Personality Features: Promises and Pitfalls
Authors: Riemann Georg , Chrispijn Melissa , Weisscher Nadine , Regeer Eline , Kupka Ralph W.
Published: November 2021

Background: Pharmacotherapy is a cornerstone in bipolar disorder (BD) treatment whereas borderline personality disorder (BPD) is treated primarily with psychotherapy. Given the overlap in symptomatology, patients with BD may benefit from psychotherapy designed for BPD.

Aims: This paper reports the findings of a non-controlled open feasibility study of STEPPS training in patients with BD and borderline personality features (BPF).

Methods: Outpatients with BD were screened for BPD, and if positive interviewed with SCID-II. Patients with at least three BPF, always including impulsivity and anger burst, were included in the intervention study. Severity of BD and BPD and quality of life were assessed. Descriptive statistics were performed.

Results: Of 111 patients with BD 49.5% also screened positive on BPD according to PDQ-4+, and 52.3% of these had BPD according to SCID-II. Very few participants entered the intervention study, and only nine patients completed STEPPS. Descriptive statistics showed improvement on all outcome variables post treatment, but no longer at 6-month follow up. We reflect on the potential reasons for the failed inclusion.

Conclusion: Features of BPD were highly prevalent in patients with BD. Still, recruiting patients for a psychological treatment originally designed for BPD proved to be difficult. Feedback of participants suggests that the association of STEPPS with “borderline” had an aversive effect, which may have caused limited inclusion for screening and subsequent drop-out for the treatment. Therefore, STEPPS should be adapted for BD to be an acceptable treatment option.

Clinical Trial Registration:www.ClinicalTrials.gov/3856, identifier: NTR4016.
Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double- Blind, Randomized, Placebo-Controlled Trial
Authors: Zhou Jiaojiao , Chen Xu , Xiao Le , Zhou Jingjing , Feng Lei , Wang Gang
Published: November 2021

Background: Insomnia is a common clinical manifestation in patients with depression. Insomnia is not only a depression symptom but also an independent risk factor for recurrence. Cordyceps militaris (C. militaris) is thought to have the potential to treat insomnia. This study aimed to examine the efficacy and safety of duloxetine with C. militaris in improving sleep symptoms in patients with depression.

Methods: This study was a single-center, randomized, double-blind, placebo-controlled study that recruited outpatients admitted to Beijing Anding hospital from January 2018 to January 2019. Major depressive disorder (MDD) with insomnia was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) criteria and Mini-International Neuropsychiatric Interview (M.I.N.I.). Eligible subjects will be randomly assigned to two treatment groups in a 1:1 ratio, and receive treatment and follow-up of about 6 weeks of duloxetine plus Cordyceps militaris or placebo, respectively. The severity of depression and insomnia was evaluated at baseline and at 1, 2, 4, and 6 weeks using the 17-item Hamilton Depression Scale (HAMD-17) and Athens Insomnia Scale (AIS).

Results: A total of 59 subjects were included in the study (31 in the placebo group and 28 in the C. militaris group). 11 (18.6%) participants withdrew during the study period, 5 (17.9%) in the C. militaris group, and 6 (19.3%) in the placebo group. Depressive and sleep symptoms in all patients reduced over time. We found that the total scores of AIS and its subscales decreased more in the placebo group compared to the C. militaris group (p < 0.05). Secondary outcome revealed that there were no significant differences between the two groups in total HAMD-17 and its sleep factor scores (p > 0.05) at 1, 2, 4, and 6 weeks after treatment initiation. The incidences of adverse events were not significantly different between the two groups (all p > 0.05).

Conclusion:C. militaris at the current dose and duration did not improve sleep symptoms in patients with depression, but it is safe with rare side effects.
Food Insecurity and Bullying Victimization Among 170,618 Adolescents in 59 Countries
Authors: Liang Kaixin , Chi Xinli , Chen Si-Tong , Clark Cain Craig Truman , Zhang Yanjie , Wang Jian
Published: November 2021

Background: Bullying victimization can impose long-lasting impacts on adolescent's current and subsequent well-being. Understanding the correlates of bullying victimization and how to prevent its occurrence is an urgent need. Food insecurity, an indicator of low socioeconomic status, may be related to bullying victimization. However, research on the association between food insecurity and bullying victimization is limited. Using a representative global sample, this study aimed to investigate the association between food insecurity and bullying victimization in adolescents and whether the association varied between country income levels, sexes, and age groups.

Methods: Using cross-sectional, school-based data by 170,618 adolescents in 59 countries from the Global School-based Student Health Survey, multivariable logistic regression and meta-analysis were conducted to investigate the overall, country-stratified, sex-stratified, and age-stratified associations.

Results: The prevalence of bullying victimization was 33.3%. In the total sample, adolescents with food insecurity showed significantly higher odds for bullying victimization than those without no food insecurity with a pooled odds ratio (OR) being 1.37 (1.28, 1.47). Further, the association was stronger in higher-income countries, females, and older adolescents.

Conclusions: Bullying victimization is prevalent among global adolescents with food insecurity being a significant correlate. The identification of adolescents with perceptions of food insecurity and remedying this condition may be important to reduce the prevalence of bullying. This highlights the need to design and implement sex- and age-specific interventions focusing on remedying food insecurity and bullying victimization among in-school adolescents by taking country income levels into account.
Attitudes Towards Appearance and Body-Related Stigma Among Young Women With Obesity and Psoriasis
Authors: Mazurkiewicz Natalia , Krefta Jarosław , Lipowska Małgorzata
Published: November 2021

The goal of this study was to investigate the role of the subjective assessment of one's body image in the relationship between objective indices of appearance and perceived stigma in young women affected by obesity and psoriasis. These are chronic diseases that decrease one's physical attractiveness and are associated with stigmas related to body defects. A total of 188 women in early adulthood took part in the study (M = 25.58; SD = 2.90), including obese women (n = 54), women suffering from psoriasis (n = 57), and a control group (n = 77). The participants completed the Multidimensional Body-Self Relations Questionnaire, Perceived Stigmatisation Questionnaire, and a socio-demographic questionnaire. Anthropometric data were gathered using a body composition analyzer. Objective parameters of body shape were calculated (WHR and ICO). Subjective assessment of one's body and attitudes towards one's body were found to influence perceived stigma, independently of the condition causing the stigma and of the objective appearance of the participant. This study did not support the existence of a relationship between parameters regarding body shape and sense of stigma, even when subjective body assessment acted as a moderator. At the same time, body mass was a strong predictor of levels of perceived stigma. Women affected with obesity perceived a higher level of stigma than the other groups. The severity of psoriasis did not impact the perceived stigma. Moreover, women with psoriasis assessed their health—as a part of the assessment of their bodies—the highest, which may explain the lower perceived stigma in this group.
Changes of the Public Attitudes of China to Domestic COVID-19 Vaccination After the Vaccines Were Approved: A Semantic Network and Sentiment Analysis Based on Sina Weibo Texts
Authors: Gao Hao , Guo Difan , Wu Jing , Zhao Qingting , Li Lina
Published: November 2021

Introduction: On December 31, 2020, the Chinese government announced that the domestic coronavirus disease-2019 (COVID-19) vaccines have obtained approval for conditional marketing and are free for vaccination. This release drove the attention of the public and intense debates on social media, which reflected public attitudes to the domestic vaccine. This study examines whether the public concerns and public attitudes to domestic COVID-19 vaccines changed after the official announcement.

Methods: This article used big data analytics in the research, including semantic network and sentiment analysis. The purpose of the semantic network is to obtain the public concerns about domestic vaccines. Sentiment analysis reflects the sentiments of the public to the domestic vaccines and the emotional changes by comparing the specific sentiments shown on the posts before and after the official announcement.

Results: There exists a correlation between the public concerns about domestic vaccines before and after the official announcement. According to the semantic network analysis, the public concerns about vaccines have changed after the official announcement. The public focused on the performance issues of the vaccines before the official approval, but they cared more about the practical issues of vaccination after that. The sentiment analysis showed that both positive and negative emotions increased among the public after the official announcement. “Good” was the most increased positive emotion and indicated great public appreciation for the production capacity and free vaccination. “Fear” was the significantly increased negative emotion and reflected the public concern about the safety of the vaccines.

Conclusion: The official announcement of the approval for marketing improved the Chinese public acceptance of the domestic COVID-19 vaccines. In addition, safety and effectiveness are vital factors influencing public vaccine hesitancy.
Implementation of a Healthcare of Elderly Course With Multi-Professional Teachers for Undergraduate Medical Students in a Public University in Malaysia—A Quasi-Experimental Pre and Post Study
Authors: Ng Zhi Ling , Mat Din Hazwan , Zakaria Nor Fadhlina , Inche Mat Liyana Najwa , Wan Zukiman Wan Zul Haikal , Md Shah Anim , Daut Ummi Nadira , Sallehuddin Hakimah Mohammad
Published: November 2021

Clinical practise in the ageing population is changing from organ-specific specialty care to holistic care. This is done through comprehensive geriatric assessment and multi-disciplinary team management. Hence, we adopted an approach consisting of multi-professional teachers teaching a Healthcare of Elderly Course (HEC), in a public university in Malaysia. We aimed to analyze the students' attitude, self-perceived competency and interest in geriatric medicine as a career before and after the course. We also investigated variables that might influence this interest among these students. All 96 students in the course were invited to participate in the survey. Sixty-eight (70.8%) completed both pre and post-course questionnaires. Although most students (93%) have a positive attitude (University of California at Los Angeles Geriatric Attitude Scale >3) toward older adults at baseline, it did not significantly increase post-course. We found that the mean scores for self-perceived competency increased from 3.62 (±0.76) to 3.81 (±0.56) post-course (p < 0.01). However, the students remained neutral with no significant change in the mean interest in pursuing a geriatric medicine career after the course. Students with higher self-perceived competency post-course were found to be more interested in geriatric medicine (β = 0.56, p < 0.001). In conclusion, the HEC in our centre could sustain a positive attitude and increase self-perceived competency in students. It is important to increase the preparedness of our graduates in managing older adults with frailty and multimorbidity. Future studies may involve inter-professional education of students from multiple disciplines undergoing the same course to nurture real-life collaborations in managing the ageing population.
Protocol for a Systematic Review on the Effectiveness of Interventions to Reduce Exposure to Occupational Solar UltraViolet Radiation (UVR) Among Outdoor Workers
Authors: Modenese Alberto , Loney Tom , Rocholl Marc , Symanzik Cara , Gobba Fabriziomaria , John Swen Malte , Straif Kurt , Silva Paulo Marilia
Published: November 2021

Background: Solar UltraViolet Radiation (UVR) is considered the most relevant occupational carcinogenic exposure in terms of the number of workers exposed (i.e., outdoor workers) and UVR-induced skin cancers are among the most frequent types of occupational cancers worldwide. This review aims to collect and evaluate all the available preventive interventions conducted on outdoor workers to reduce their solar UVR related risk, with the final purpose of reducing the burden of occupational skin cancers for outdoor workers.

Methods: We will search the following databases for peer-reviewed original research published: MEDLINE (through PubMed), Scopus, and EMBASE. We will include only interventional studies, both randomized and non-randomized, with an adequate comparison group, therefore excluding cross-sectional studies, as well as case-reports/series, reviews, and letters/comments. The systematic review will adhere to the “Preferred Reporting Items for Systematic reviews and Meta-Analyses” (PRISMA) guidelines for reporting systematic reviews. After the literature search, studies to be included will be independently reviewed by two Authors, first based on title and abstract, then based on the full text, according to the inclusion criteria. Conflicts will be solved by a third Author. Two authors will independently extract the required data from included studies and perform quality assessment according to the relevant domain for Risk of Bias assessment proposed by the Cochrane collaboration group. In case of sufficient homogeneity of interventions and outcomes evaluated, results from subgroups of studies will be pooled together in a meta-analysis.

Discussion: Following the principles for the evaluation of interventions for cancer prevention established by the International Agency for Research on Cancer, this systematic review will investigate the effectiveness of the interventions, and consequently it will provide reliable indications for the actual reduction of skin cancer incidence in outdoor workers.
Candida Isolates From Blood and Other Normally Sterile Foci From ICU Patients: Determination of Epidemiology, Antifungal Susceptibility Profile and Evaluation of Associated Risk Factors
Authors: Wang Bo , He Xinlong , Lu Feng , Li Yajuan , Wang Yuerong , Zhang Min , Huang Ying , Xia Jinxing
Published: November 2021

Background: The clinical diagnosis and therapy for ICU patients with invasive candidiasis are challenged by the changes of Candida community composition and antimicrobial resistance. The epidemiology and drug sensitivity of candidiasis in ICU as well as its risk factors and drug resistance mechanism were investigated.

Methods: In the present study, 115 patients in ICU were recruited from June 2019 through July 2020. Among them, 83 Candida isolates were identified with MALDI-TOF mass spectrometry. The susceptibility to antifungals was measured by microdilution method. The molecular mechanisms of azole-resistant Candida tropicalis were explored by sequencing, and their outcomes were explicitly documented.

Results:Candida glabrata and C. tropicalis were the predominant non-C. albicans Candida. The specimen sources were mainly urine, bronchoalveolar lavage fluid and blood. The age, length of hospitalization, tracheotomy, diabetes and concomitant bacterial infection were the main risk factors for candidiasis. The majority of Candida species exhibited susceptibility to antifungals. However, certain C. tropicalis were frequently resistant to azoles. The polymorphism of the ERG11 in C. tropicalis was likely associated with azole resistance.

Conclusion: The multiple risk factors for candidiasis in ICU patients need to be considered. Certain C. tropicalis exhibit resistance to azoles likely due to the ERG11 gene polymorphism.
Open Science Indicators as Metadata Fields?
Authors: Fradkin Chris , Mugnaini Rogério
Published: November 2021

Since 2000, there has been qualitative growth in the field of scientometrics. Innovations such as the DOI and the ORCID have irrevocably changed the scientific landscape. They have enabled analyses previously unheard of, in the decades preceding the new millennium. This paper proposes open science indicators (open data, open material, preregistration) as article-specific metadata fields. The authors reference the history of funding information, from bare acknowledgements to metadata field. The authors describe the mission of the Center for Open Science, and its TOP Factor database, as well as the performance of open science badges. Possibilities for a pilot study are explored, with an acknowledgement of the complexity of this undertaking.
The “Creatures” in Your Head
Authors: Dissing-Olesen Lasse
Published: November 2021

Imagine an overgrown rainforest full of all kinds of different creatures. That is exactly how I want you to picture your brain. In your dense and lively brain-jungle, the billions of trees are called neurons and, for every neuron-tree in your brain, there are one or more mystical jungle-creatures. Some of these creatures wrap tightly around the tree trunks, while others nurture the trees’ leaves and hug their roots. A special kind of dynamic jungle-creature eats damaged branches and keeps intruders away. These creatures are all called glial cells and, without them, your brain-jungle would collapse. Let us explore this remarkable jungle, to learn more about these astonishing glial-creatures and how we can observe them.
A Mathematical Model of Universal Basic Income and Its Numerical Simulations
Authors: Bertotti Maria Letizia
Published: November 2021

In this paper, an elementary mathematical model describing the introduction of a universal basic income in a closed market society is constructed. The model is formulated in terms of a system of nonlinear ordinary differential equations, each of which gives account of how the number of individuals in a certain income class changes in time. Societies ruled by different fiscal systems (with no taxes, with taxation and redistribution, with a welfare system) are considered and the effect of the presence of a basic income in the various cases is analysed by means of numerical simulations. The main findings are that basic income effectively acts as a tool of poverty alleviation: indeed, in its presence the portion of individuals in the poorest classes and economic inequality diminish. Of course, the issue of a universal basic income in the real world is more complex and involves a variety of aspects. The goal here is simply to show how mathematical models can help in forecasting scenarios resulting from one or the other policy.
Defining Fluoroquinolone Resistance-Mediating Mutations from Non-Resistance Polymorphisms in Mycoplasma hominis Topoisomerases
Authors: Sharratt Martin , Sands Kirsty , Portal Edward A. R. , Boostrom Ian , Mondeja Brian A. , Rodríguez Nadia M. , Jones Lucy C. , Spiller Owen B.
Published: November 2021

Often dismissed as a commensal, Mycoplasma hominis is an increasingly prominent target of research due to its role in septic arthritis and organ transplant failure in immunosuppressed patients, particularly lung transplantation. As a mollicute, its highly reductive genome and structure render it refractile to most forms of treatment and growing levels of resistance to the few sources of treatment left, such as fluoroquinolones. We examined antimicrobial susceptibility (AST) to fluoroquinolones on 72 isolates and observed resistance in three (4.1%), with corresponding mutations in the quinolone resistance-determining region (QRDR) of S83L or E87G in gyrA and S81I or E85V in parC. However, there were high levels of polymorphism identified between all isolates outside of the QRDR, indicating caution for a genomics-led approach for resistance screening, particularly as we observed a further two quinolone-susceptible isolates solely containing gyrA mutation S83L. However, both isolates spontaneously developed a second spontaneous E85K parC mutation and resistance following prolonged incubation in 4 mg/L levofloxacin for an extra 24–48 h. Continued AST surveillance and investigation is required to understand how gyrA QRDR mutations predispose M. hominis to rapid spontaneous mutation and fluoroquinolone resistance, absent from other susceptible isolates. The unusually high prevalence of polymorphisms in M. hominis also warrants increased genomics’ surveillance.
Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces
Authors: Arnhold Jürgen
Published: November 2021

In our organism, mucous surfaces are important boundaries against the environmental milieu with defined fluxes of metabolites through these surfaces and specific rules for defense reactions. Major mucous surfaces are formed by epithelia of the respiratory system and the digestive tract. The heme peroxidases lactoperoxidase (LPO), myeloperoxidase (MPO), and eosinophil peroxidase (EPO) contribute to immune protection at epithelial surfaces and in secretions. Whereas LPO is secreted from epithelial cells and maintains microbes in surface linings on low level, MPO and EPO are released from recruited neutrophils and eosinophils, respectively, at inflamed mucous surfaces. Activated heme peroxidases are able to oxidize (pseudo)halides to hypohalous acids and hypothiocyanite. These products are involved in the defense against pathogens, but can also contribute to cell and tissue damage under pathological conditions. This review highlights the beneficial and harmful functions of LPO, MPO, and EPO at unperturbed and inflamed mucous surfaces. Among the disorders, special attention is directed to cystic fibrosis and allergic reactions.
Determining the Print Quality Due to Deformation of the Halftone Dots in Flexography
Authors: Valdec Dean , Hajdek Krunoslav , Vragović Lucia , Geček Robert
Published: November 2021

This paper researches the issues related to the print quality in flexography, especially the influence of the print run and inadequate printing settings on dot deformation. Dot deformation can lead to inconsistencies in print quality, such as a loss of highlight tones or an unpredictable increase in tonal value. This research was conducted on two concrete examples of flexible packaging printed on transparent films. All significant parameters of dot deformation were evaluated, including dot coverage, dot sharpness and the uniformity of the ink density. The increase in the coverage values in the midtones was linear throughout the entire print run, while in the light tones, it was more logarithmic. The overall percentage deviations from the reference value were 6.3% in the midtones and 52.6% in the light area. The increase in dot coverage was due to the wear of the polymer plate, which caused the side shoulders of the dot to become a part of the printing surface. An analysis of the ink density showed a much more homogeneous shape of the dot at the beginning of the print run. The correct ratio of the anilox roller line screen to the line ruling of the printing plate is important in order to ensure a minimum dot size in print.
Image-Free Ultrasound Blood-Flow Monitoring Circuit System with Automatic Range-Gate Positioning Scheme: A Pilot Study
Authors: Park Hyun-Tae , Um Ji-Yong
Published: November 2021

This work proposes a proof-of-concept ultrasound blood-flow-monitoring circuit system using a single-element transducer. The circuit system consists of a single-element ultrasonic transducer, an analog interface circuit, and a field-programmable gate array (FPGA). Since the system uses a single-element transducer, an ultrasound image cannot be reconstructed unless scanning with mechanical movement is used. An ultrasound blood-flow monitor basically needs to acquire a Doppler sample volume by positioning a range gate at a vessel region on a scanline. Most recent single-transducer-based ultrasound pulsed-wave Doppler devices rely on a manual adjustment of the range gate to acquire Doppler sample volumes. However, the manual adjustment of the range gate depends on the user’s experience, and it can be time consuming if a transducer is not properly positioned. Thus, automatic range-gate-positioning is more desirable for image-free pulsed-wave Doppler devices. This work proposes a circuit system which includes a new automatic range-gate-positioning scheme. It blindly tracks the position of a blood vessel on a scanline by using the accumulation of Doppler amplitude deviations and a hysteresis slicing function. The proposed range-gate-positioning scheme has been implemented in an FPGA for real-time operation and is based on addition-only computations, except for filter parts to reduce the complexity of computation in the hardware. The proposed blood-flow-monitoring circuit system has been implemented with discrete commercial chips for proof-of-concept purposes. It uses a center frequency of 2 MHz and a system-clock frequency of 20 MHz. The FPGA only utilizes 5.6% of slice look-up-tables (LUTs) for implementation of the range-gate-positioning scheme. For measurements, the circuit system was utilized to interrogate a customized flow phantom model, which included two vessel-mimicking channels. The circuit system successfully acquired Doppler sample volumes by positioning a range gate on a fluid channel. In addition, the estimated Doppler shift frequency shows a good agreement with the theoretical value.
Usage of Barkhausen Noise for Assessment of Corrosion Damage on Different Low Alloyed Steels
Authors: Pastorek Filip , Decký Martin , Neslušan Miroslav , Pitoňák Martin
Published: November 2021

This study deals with corrosion damage of low alloyed feritic steels of variable strength. Three different steels of nominal yield strength 235, 700 and 1100 MPa were subjected to the variable degree of corrosion attack developed in the corrosion chamber under a neutral salt spray (NSS) atmosphere. The corrosion damage was investigated by the use of conventional metallographic observations when the thickness of corroded layer was quantified. Moreover, non-destructive magnetic technique, based on Barkhausen noise, was also employed. It was found that the rate of corrosion damage decreases along with the increasing number of days in the chamber. The similar evolution can be also found for Barkhausen noise emission and the extracted parameters from the emission. It can be reported that conventional rms value of Barkhausen noise signal as well as FWHM (full width at half maximum of Barkhausen noise envelope) can be linked with the corrosion extent, especially in the early phases of corrosion attack. The PP (peak position of Barkhausen noise envelope) values exhibit poor sensitivity.
Portuguese Kelps: Feedstock Assessment for the Food Industry
Authors: Pacheco Diana , Miranda Giuseppe , Rocha Carolina P. , Pato Rosinda L. , Cotas João , Gonçalves Ana M. M. , Santos Sandra M. Dias , Bahcevandziev Kiril , Pereira Leonel
Published: November 2021

Seaweeds have been incorporated in the daily diet of several human cultures since ancient times, due to their nutritional characteristics and healthy properties. The brown seaweeds Undaria pinnatifida, Saccharina latissima, Sacchoriza polyschides, and Laminaria ochroleuca were collected in the Viana do Castelo (Portugal) bay to assess their proximate composition analysis. As a result, the algal biomass was dried, and its moisture and ash content were determined. The dried biomass was then analyzed for total nitrogen/total protein (using the Kjeldahl method), total fiber content (through fiber analyzer digestion), total lipids (in a Soxhlet apparatus), and fatty acid characterization (by gas chromatography-mass spectrometry). Apart from phosphorus, which was analyzed by spectrophotometry, the ashes were employed for mineral and trace element characterization via dry mineralization and quantified using flame atomic absorption spectrometry. Moreover, the total phenolic content was assessed spectrophotometrically by the Folin-Ciocalteu method in the algal aqueous extracts. Analyses showed that their protein concentrations ranged from 12 to 24% dry weight (DW), while lipid concentrations varied between 0.51% and 1.52% DW. Regarding the carbohydrate concentration in these seaweeds, a concentration between 48% and 60% DW was observed. The S. polyschides had the highest overall total phenolic content (6.19 × 10−3 g GAE/100 g of dried algae), while L. ochroleuca had the lowest amount (3.72 × 10−3 g GAE/100 g of dried algae). U. pinnatifida had the highest total fatty acid content (35.13 mg/g DW), whereas S. latissima presented the lowest value (22.59 mg/g DW). Significant concentrations of highly unsaturated fatty acids (HUFA) were observed in both seaweeds, with U. pinnatifida having the highest value (10.20 mg/g DW) and S. latissima the lowest content (4.81 mg/g DW). It is also highlighted that these seaweeds have a nutritional relevance as a source of essential nutrients, including nitrogen, potassium, sodium, calcium, magnesium, and iron.
Establishing Effective Remedial Instruction Grouping Using the Rough Set Theory and Grey Structural Modeling
Authors: Wang Bor-Tyng
Published: November 2021

In the field of education, the assessment of a student’s learning performance is based on his final course scores. Few people care about what is behind the numbers. Most of the time, the final scores represent the end of the course because students have already passed the subject. Low-level students especially, still have a lot of misconceptions, but they do not know how to make up for their poor grasp of the subject in preparation for future study. Instead of just giving students their scores, teachers are encouraged to provide remedial instruction to students for their future learning. This study aims to establish an effective method using rough set theory and grey structural modeling to determine which attributes affect students’ final scores and to cluster students accordingly. A rough set algorithm generates a set of attributes for an assessment list. Grey structural modeling (GSM) is then used to cluster students who have the same weaknesses in English. GSM changes from one dimension to two dimensions, and calculates the relative distance, so that cluster analysis can be performed. Targeted remedial instruction can then be given to each similar ability student grouping. The results revealed that through integrating the two theories, teachers could more effectively sort students into groups. Students benefit by coming to understand their weaknesses in English instead of just receiving a single score at the end of the semester, and they can learn with their peers as well. Teachers can adjust their teaching strategies and syllabus design based on the analytical results to target the students’ needs.
Meloidogyne graminicola—A Threat to Rice Production: Review Update on Distribution, Biology, Identification, and Management
Authors: Rusinque Leidy , Maleita Carla , Abrantes Isabel , Palomares-Rius Juan E. , Inácio Maria L.
Published: November 2021

Rice (Oryza sativa L.) is one of the main cultivated crops worldwide and represents a staple food for more than half of the world population. Root-knot nematodes (RKNs), Meloidogyne spp., and particularly M. graminicola, are serious pests of rice, being, probably, the most economically important plant-parasitic nematode in this crop. M. graminicola is an obligate sedentary endoparasite adapted to flooded conditions. Until recently, M. graminicola was present mainly in irrigated rice fields in Asia, parts of the Americas, and South Africa. However, in July 2016, it was found in northern Italy in the Piedmont region and in May 2018 in the Lombardy region in the province of Pavia. Following the first detection in the EPPO region, this pest was included in the EPPO Alert List as its wide host range and ability to survive during long periods in environments with low oxygen content, represent a threat for rice production in the European Union. Considering the impact of this nematode on agriculture, a literature review focusing on M. graminicola distribution, biology, identification, and management was conducted.
Intracellular ATP Concentration and Implication for Cellular Evolution
Authors: Greiner Jack V. , Glonek Thomas
Published: November 2021

Crystalline lens and striated muscle exist at opposite ends of the metabolic spectrum. Lens is a metabolically quiescent tissue, whereas striated muscle is a mechanically dynamic tissue with high-energy requirements, yet both tissues contain millimolar levels of ATP (>2.3 mM), far exceeding their underlying metabolic needs. We explored intracellular concentrations of ATP across multiple cells, tissues, species, and domains to provide context for interpreting lens/striated muscle data. Our database revealed that high intracellular ATP concentrations are ubiquitous across diverse life forms including species existing from the Precambrian Era, suggesting an ancient highly conserved role for ATP, independent of its widely accepted view as primarily “metabolic currency”. Our findings reinforce suggestions that the primordial function of ATP was non-metabolic in nature, serving instead to prevent protein aggregation.
Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation
Authors: Denny William A. , Flanagan Jack U.
Published: November 2021

The discoidin domain receptor tyrosine kinases DDR1 and DDR2 are distinguished from other kinase enzymes by their extracellular domains, which interact with collagen rather than with peptidic growth factors, before initiating signaling via tyrosine phosphorylation. They share significant sequence and structural homology with both the c-Kit and Bcr-Abl kinases, and so many inhibitors of those kinases are also effective. Nevertheless, there has been an extensive research effort to develop potent and specific DDR inhibitors. A key interaction for many of these compounds is H-bonding to Met-704 in a hydrophobic pocket of the DDR enzyme. The most widespread use of DDR inhibitors has been for cancer therapy, but they have also shown effectiveness in animal models of inflammatory conditions such as Alzheimer’s and Parkinson’s diseases, and in chronic renal failure and glomerulonephritis.
Comparison of Different Systemic Therapeutic Regimes in Resectable Soft-Tissue Sarcoma—Results of a Network Meta-Analysis
Authors: Haussmann Jan , Matuschek Christiane , Bölke Edwin , Tamaskovics Balint , Corradini Stefanie , Wessalowski Rüdiger , Maas Kitti , Schmidt Livia , Orth Klaus , Peiper Matthias , Keitel Verena , Feldt Torsten , Jensen Björn-Erik Ole , Luedde Tom , Fischer Johannes , Knoefel Wolfram Trudo , Ashmawy Hany , Pedotoa Alessia , Kammers Kai , Budach Wilfried
Published: November 2021

Background: The standard treatment of high-risk soft-tissue sarcoma consists of surgical resection followed by risk-adapted radiation therapy. Further treatment options that may improve local and systemic tumor control, including chemotherapy, are not well established. Due to the heterogeneity of the disease, different systemic approaches as well as their application at different time points have been attempted. Methods: We conducted a systematic literature search for randomized clinical trials in the treatment of localized, resectable high-risk adult soft-tissue sarcoma comparing different treatment modalities according to the PRISMA guidelines. We extracted published hazard ratios and number of events for the endpoints overall and disease-free survival (OS; DFS) as well as local and distant recurrence-free interval (LRFI; DRFI). The different modalities were compared in a network meta-analysis against the defined standard treatment surgery ± radiotherapy using the inverse-variance heterogeneity model. Results: The literature search identified 25 trials including 3453 patients. Five different treatment modalities were compared in the network meta-analysis. The addition of adjuvant chemotherapy significantly improved OS compared to surgery ± radiotherapy alone (HR = 0.86; CI-95%: 0.75–0.97; p = 0.017). Likewise, neoadjuvant chemotherapy combined with regional hyperthermia (naCTx + HTx) also led to superior OS (HR = 0.45; CI-95%: 0.20–1.00; p = 0.049). Both neoadjuvant chemotherapy alone (naCTx) and perioperative chemotherapy (periCTx) did not improve OS (HR = 0.61; CI-95%: 0.29–1.29; p = 0.195 and HR = 0.66; CI-95%: 0.30–1.48; p = 0.317, respectively). Histology-tailored chemotherapy (htCTx) also did not improve survival compared to surgery ± radiotherapy (HR = 1.08; CI-95%: 0.45–2.61; p = 0.868). The network analysis of DFS, LRFI, and DRFI revealed a similar pattern between the different treatment regimens. Adjuvant chemotherapy significantly improved DFS, LRFI, and DRFI compared to surgery ± radiotherapy. In direct comparison, this advantage of adjuvant chemotherapy was restricted to male patients (HR = 0.78; CI-95%: 0.65–0.92; p = 0.004) with no effect for female patients (HR = 1.08; CI-95%: 0.90–1.29; p = 0.410). Conclusions: Standardized chemotherapy in high-risk soft-tissue sarcoma appears to be of added value irrespective of timing. The benefit of adjuvant chemotherapy seems to be restricted to male patients. The addition of regional hyperthermia to neodjuvant chemotherapy achieved the best effect sizes and might warrant further investigation.
The Burden of Survivorship on Hematological Patients—Long-Term Analysis of Toxicities after Total Body Irradiation and Allogeneic Stem Cell Transplantation
Authors: Oertel Michael , Martel Jonas , Mikesch Jan-Henrik , Scobioala Sergiu , Reicherts Christian , Kröger Kai , Lenz Georg , Stelljes Matthias , Eich Hans Theodor
Published: November 2021

Total body irradiation is an effective conditioning modality before autologous or allogeneic stem cell transplantation. With the whole body being the radiation target volume, a diverse spectrum of toxicities has been reported. This fact prompted us to investigate the long-term sequelae of this treatment concept in a large patient cohort. Overall, 322 patients with acute leukemia or myelodysplastic syndrome with a minimum follow-up of one year were included (the median follow-up in this study was 68 months). Pulmonary, cardiac, ocular, neurological and renal toxicities were observed in 23.9%, 14.0%, 23.6%, 23.9% and 20.2% of all patients, respectively. The majority of these side effects were grades 1 and 2 (64.9–89.2% of all toxicities in the respective categories). The use of 12 Gray total body irradiation resulted in a significant increase in ocular toxicities (p = 0.013) and severe mucositis (p < 0.001). Renal toxicities were influenced by the age at transplantation (relative risk: 1.06, p < 0.001) and disease entity. In summary, total body irradiation triggers a multifaceted, but manageable, toxicity profile. Except for ocular toxicities and mucositis, a 12 Gray regimen did not lead to an increase in long-term side effects.