bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Status and Prospects of Research on Ischemia-Reperfusion Injury and Ferroptosis
Authors: Hou Lin , Li Xiaodong , Su Chang , Chen Kailin , Qu Maoxing
Published: August 2022

The pathogenesis of ischemia-reperfusion injury is not fully understood, most of the current clinical treatment methods mainly relieve symptoms, and cannot prevent fundamentally. The mechanism of Ferroptosis has been extensively studied in recent years, but primarily focused on its therapeutic effects on tumors. After careful comparison, it is easy to find that the symptoms of ischemia-reperfusion injury often accompany by increased lipid peroxidation and increased intracellular iron level are the same as the manifestations of iron-dependent non-apoptotic Ferroptosis. Based on this “coincidence”, we launched this survey. After reading a lot of literature, we found that Ferroptosis is the first step of ischemia-reperfusion injury, and cell necrosis and inflammation are the subsequent steps secondary to Ferroptosis. In this review, we have collected and sorted out the current knowledge about the role and targets of Ferroptosis in the process of ischemia-reperfusion injury. And future studies may be biased towards exploring the use of ferroptosis inhibitors in combination with other treatment options.
Transient pseudohypoaldosteronism in infancy mainly manifested as poor appetite and vomiting: Two case reports and review of the literature
Authors: Tuoheti Yueerlanmu , Zheng Yucan , Lu Yan , Li Mei , Jin Yu
Published: August 2022

Introduction

Transient Pseudohypoaldosteronism (TPHA) is a very rare condition usually secondary to urinary tract malformations (UTM) and/or urinary tract infection (UTI). It is characterized by hyperkalemia, hyponatremia, metabolic acidosis, and elevated plasma aldosterone levels. Given that the predominant manifestations of TPHA patients are digestive tract symptoms, such as poor appetite, vomiting, and weight gain, it is easily misdiagnosed as digestive tract diseases.

Case reports

Two children with poor appetite and vomiting were admitted to the Department of Gastroenterology, Children’s Hospital of Nanjing Medical University, from 2020 to 2021. Laboratory test results of these two children revealed hyponatremia (< 135.00 mmol/L), hyperkalemia (> 5.50 mmol/L), and hyperaldosteronism (> 180.00 ng/L). Moreover, genetic tests demonstrated no genetic variants highly associated with the phenotype in both cases. The two patients were subsequently treated with electrolyte correction. One of them also treated with antibiotics and one of them underwent surgery. They were followed for 8 and 4 months, respectively. No complications were observed during the follow-up period. This review aimed to outline both cases with parental consent.

Conclusion

Transient pseudohypoaldosteronism should be considered in children younger than 6 months, presenting with vomiting, poor appetite, unexplained hyponatremia, hyperkalemia, elevated aldosterone levels, and urethral malformation or urinary tract infection. Furthermore, attention should be paid to whether salt supplementation or anti-infection therapy is effective.
Randomized controlled trial of early arachidonic acid and docosahexaenoic acid enteral supplementation in very preterm infants
Authors: Álvarez Patricia , Ramiro-Cortijo David , Montes María Teresa , Moreno Bárbara , Calvo María V. , Liu Ge , Esteban Romero Ana , Ybarra Marta , Cordeiro Malaika , Clambor Murube Marina , Valverde Eva , Sánchez-Pacheco Aurora , Fontecha Javier , Gibson Robert , Saenz de Pipaon Miguel
Published: August 2022

Objective

To evaluate changes in blood long-chain polyunsaturated fatty acid (LCPUFA) and oxylipin concentrations in very preterm infants from birth to 36 weeks’ postmenstrual age (WPA) after providing an emulsified arachidonic acid (ARA):docosahexaenoic acid (DHA) supplement at two different concentrations.

Study design

This prospective, randomized trial assigned infants to receive a supplement (1) 80:40 group (80 mg/kg/day ARA and 40 mg/kg/day DHA, n = 9) or (2) 120:60 group (120 mg/kg/day ARA and 60 mg/kg/day DHA, n = 9). Infants received supplement daily from birth until 36 WPA. At baseline, 21 days of life and 36 WPA, the LCPUFAs were measured in plasma by gas chromatography/mass spectrophotometry. Additionally, LCPUFAs and oxylipins were analyzed in whole blood by ultra-high-performance liquid chromatography-tandem mass spectrometry. Furthermore, a sample of oral mucosa was obtained to analyze single-nucleotide polymorphism located in the FADS1 gene by PCR.

Results

Gestational age was similar between groups (80:40 = 28+6 [27+3; 30+3] completed weeks+days; 120:60 = 29+6 [27+3; 30+5] completed weeks+days, p = 0.83). At 36 WPA, the change in plasma ARA was significantly different between groups (80:40 group = 0.15 [−0.67; 0.69] %nmol, 120:60 = 1.68 [1.38; 3.16] %nmol, p = 0.031). In whole blood, the levels of ARA-derived oxylipins (5-, 8-, 9-, 11-, 15-HETE and 8,9-EET) and EPA-derived oxylipins (18-HEPE) significantly increase from baseline to 36 WPA in the 120:60 group than the 80:40 group.

Conclusion

Supplementation at high doses (120:60 mg/kg/day) increased levels of ARA, and EPA- and ARA-derived oxylipins compared to low doses (80:40 mg/kg/day). Differences were detected in EPA metabolites without a significant increase in plasma DHA.
Narratives of Herbal Medicine Utilisation in the United Kingdom: Scoping Literature Review
Authors: Longden-Naufal Celine , Rolfe Vivien , Mackonochie Marion
Published: August 2022

Using thematic analysis of existing literature, this scoping review aims to explore the narratives of people using herbal medicine (HM) in the United Kingdom. Understanding who is using HM and why will enable better ways of facilitating the use of HM, as well as assist in designing future research. Ethnic groups were found to be primary users of HM in the United Kingdom. A sense of heritage continues to be important for these participants as it allows tradition and culture to stay alive within communities, as well as the ritualistic purposes of these plants. For women, another key demographic, concepts surrounding the naturalness of HMs are associated with the idea of femineity and self-healing. A reoccurring theme in the literature focusing on both ethnic groups and women’s perceptions is the judgement from healthcare practitioners/professionals (HCPs) when addressing the use of HM. However, studies that investigated the perceptions of HCPs on HM confirmed that they often were supportive of using HM where standard treatments had been unsuccessful, and if a patient had anecdotal evidence of a herb having been effective. Delving deeper into public narratives of HM usage will allow conventional healthcare systems to effectively integrate alternative approaches, as well as ensuring that future research into the benefits of HMs is relevant to how people use them.
Application of metabolomics and network analysis to reveal the ameliorating effect of four typical “hot” property herbs on hypothyroidism rats
Authors: Wang Yang-Yang , Sun Yan-Ping , Yang Bing-You , Wang Qiu-Hong , Kuang Hai-Xue
Published: August 2022

Herbs with a “hot” properties are frequently used to treat cold symptoms in TCM. However, the underlying mechanisms of the herbs with “hot” properties on hypothyroidism have not been investigated. This study aimed to explore four typical “hot” and “cold” property herb on hypothyroidism. Firstly, the difference efficacy between the four typical “hot” property herbs and the four typical “cold” property herbs was assessed by physical signs, thyroid function, and the metabolic profile using multivariate statistical analysis. The influence of the four typical “hot” property herbs on hypothyroidism was validated pathologically. The impact mechanism of the four typical “hot” property herbs on hypothyroidism was investigated through a metabolomics method combined with network analysis. Na+/K+-ATP, ACC1 enzyme, UCP-1, and the PI3K-Akt pathway were used to confirm the metabolite pathways and target-associated metabolites. The results showed that the four typical “hot” property herbs could significantly improve physical signs, thyroid function, and the metabolic profile in hypothyroidism rats, the four typical “cold” property herbs did not show any benefit. Moreover, the four typical “hot” property herbs could improve lipid metabolism, energy metabolism, and thyroid hormone levels by the PI3K-Akt signaling pathway, Ca2+- AMPK signaling pathways, purine metabolism, and tryptophan metabolism. Additionally, the levels of UCP-1, Na+/K + -ATP enzyme, and ACC1 were ameliorated by the four typical “hot” property herbs in hypothyroidism rats. Therefore, a metabolomics strategy combined with network analysis was successfully performed and interpreted the mechanism of the four typical “hot” property herbs on hypothyroidism based on the theory of “cold and hot” properties of TCM well.
The critical role of dysregulated autophagy in the progression of diabetic kidney disease
Authors: Zhang Ziwei , Sun Yuting , Xue Jiaojiao , Jin De , Li Xiangyan , Zhao Daqing , Lian Fengmei , Qi Wenxiu , Tong Xiaolin
Published: August 2022

Diabetic kidney disease (DKD) is one of the major public health problems in society today. It is a renal complication caused by diabetes mellitus with predominantly microangiopathy and is a major cause of end-stage renal disease (ESRD). Autophagy is a metabolic pathway for the intracellular degradation of cytoplasmic products and damaged organelles and plays a vital role in maintaining homeostasis and function of the renal cells. The dysregulation of autophagy in the hyperglycaemic state of diabetes mellitus can lead to the progression of DKD, and the activation or restoration of autophagy through drugs is beneficial to the recovery of renal function. This review summarizes the physiological process of autophagy, illustrates the close link between DKD and autophagy, and discusses the effects of drugs on autophagy and the signaling pathways involved from the perspective of podocytes, renal tubular epithelial cells, and mesangial cells, in the hope that this will be useful for clinical treatment.
High Speed RGB-Based Duobinary-Encoded Visible Light Communication System Under the Impact of Turbulences
Authors: Li Lin , Sharma Abhishek
Published: August 2022

Recent gains in the pervasiveness of Visible Light Communication due to its ability to simultaneously provide lighting and communication solutions make it the best candidate for enabling smart city infrastructure to have seamless connectivity. The fundamental challenge of this technology is to ensure high data rate communication while meeting the lighting requirements of smart cities. This work is focused on providing high data rate capacity using visible light communication. To realize this, diffused channel modeling and channel modeling are considered. A total of six channels, each carrying 10 Gbps data are multiplexed using polarization division multiplexing and wavelength division multiplexing transmitted over a diffused channel of 1.3 m, while the ranges of 8 m under clear conditions and 5 m under heavy attenuation are reported with modeling. The reported results show the successful transmission of data in terms of bit error rate and eye diagram.
A magnetic flux rope configuration derived by optimization of two-spacecraft In-situ measurements
Authors: Hu Qiang , He Wen , Chen Yu
Published: August 2022

Increasingly one interplanetary coronal mass ejection (ICME) structure can propagate across more than one spacecraft in the solar wind. This usually happens when two or more spacecraft are nearly radially aligned with a relatively small longitudinal separation angle from one another. This provides multi-point measurements of the same structure and enables better characterization and validation of modeling results of the structures embedded in these ICMEs. We report such an event during October 13-14, 2019 when the Solar TErrestrial RElations Observatory Ahead (STA) spacecraft and the Parker Solar Probe (PSP) crossed one ICME structure at two different locations with nominal separations in both heliocentric distances and the longitudinal angles. We first perform an optimal fitting to the STA in-situ measurements, based on an analytic quasi-three dimensional (3D) model, yielding a minimum reduced χ2 = 0.468. Then we further apply the optimization approach by combining the magnetic field measurements from both spacecraft along their separate paths across the ICME structure. We find that the output based on the optimization (with the minimum reduced χ2 = 3.15) of the combined two-spacecraft dataset yields a more consistent result, given the much improved agreement of the model output with PSP data. The result demonstrates a magnetic flux rope configuration with clear 3D spatial variations.
Convergence of illuminating beams suffering from scattering during the individual measurement of suspended particles
Authors: Li Jiajin , Deng Hanbo , Guo Zhiming , Liao Ran , Ma Hui
Published: August 2022

The convergent illuminating beam is the key factor during the individual measurement of suspended particles in aquatic suspensions. When the illuminating beam propagates in the suspension, the particle scattering in the optical path may destroy the convergence of the illuminating beam, especially in suspensions with a high particle concentration. In this paper, using the Monte Carlo simulation, the convergence of the illuminating beam is investigated by changing the physical properties of particles, such as size and concentration, and the optical path length of the illuminating beam. A dimensionless quantity, as the product of the scattering coefficient of suspension and the optical path length, is found to determine the achievement of the convergent beam. Moreover, an individual measurement setup based on the convergence of the illuminating beam is used to measure polystyrene microspheres with different concentrations. The experiment results are consistent with those of the simulations. Furthermore, improvement strategies are proposed and proved to effectively keep the convergence of the illuminating beam in turbid water. The results in this work can provide clues for designing a similar optical apparatus used in aquatic environment monitoring.
Endophytic extract Zhinengcong alleviates heat stress-induced reproductive defect in Solanum lycopersicum
Authors: Cui Xiaoshuang , Liu Shangjia , Zhang Lina , Guo Xinping , Li Ting , Zhang Xiaoyu , Wang Qingbin , Zeng Weiqing , Huang Jiabao , Duan Qiaohong , Cao Yunyun
Published: August 2022

High temperature negatively affects reproductive process significantly, leading to tremendous losses in crop quality and yield. Zhinengcong (ZNC), a crude extract from the endophytic fungus Paecilomyces variotii, has been shown to improve plant growth and resistance to biotic and abiotic stresses. We show here that ZNC can also alleviate heat stress-induced reproductive defects in Solanum lycopersicum, such as short-term heat-induced inhibition on pollen viability, germination and tube growth, and long-term heat stress-induced pollen developmental defects. We further demonstrated that ZNC alleviates heat stress by downregulating the expressions of ROS production-related genes, RBOHs, and upregulating antioxidant related genes and the activities of the corresponding enzymes, thus preventing the over accumulation of heat-induced reactive oxygen species (ROS) in anther, pollen grain and pollen tube. Furthermore, spraying application of ZNC onto tomato plants under long-term heat stress promotes fruit and seed bearing in the field. In summary, plant endophytic fungus extract ZNC promotes the reproductive process and yield of tomato plants under heat stress and presents excellent potential in agricultural applications.
A review of the idiodynamic method as an emerging research method for the investigation of affective variables in second language acquisition
Authors: Lu Miaoyan
Published: August 2022

Recent years have witnessed the influence of the complex dynamic systems theory (CDST) in the field of second language acquisition (SLA). Thus, new research methods have also been introduced to meet the requirements of investigating the dynamic nature of learner-related factors including L2 affective variables. Among the innovative quantitative research methods which is compatible with the CDST is the idiodynamic method, the application of which is on the rise in SLA research. In this paper, an overall introduction to the idiodynamic method is presented first, followed by a review of the existing literature in SLA studies. Then, it is discussed why this innovative research method is suitable to investigate the dynamic nature of L2 learners’ affective variables in the complex network of classroom learning. Also, several relevant research questions that can potentially be formulated and answered using the idiodynamic method are discussed. The paper ends with conclusive remarks on the need for more extensive use of innovative CDST-compatible research methods such as the idiodynamic method in the prospective SLA line of inquiry.
Psychosocial health and psychological adjustment in adolescents and young adults with congenital melanocytic nevi: Analysis of self-reports
Authors: Masnari Ornella , Neuhaus Kathrin , Schiestl Clemens , Landolt Markus A.
Published: August 2022

This study assessed self-reported health-related quality of life and psychological adjustment in 43 adolescents and young adults (ages in years: 14–24, M = 17.6, SD = 2.2) with congenital melanocytic nevi (CMN) and examined associations with sociodemographic variables, characteristics of the CMN, perceived social reactions, and cognitive emotion regulation strategies. Outcome measures included the Pediatric Quality of Life Inventory™ 4.0 and the Strengths and Difficulties Questionnaire. Findings suggest impaired psychosocial health and psychological adjustment in youth with CMN compared to community norms. Impairments were associated with higher age of participants, lower socioeconomic status, visibility of the skin lesion, perceived stigmatization, poorer perceived social support, and maladaptive cognitive emotion regulation strategies (self-blame, rumination, and catastrophizing), but not with sex of participants, extent of the skin lesion, and surgical removal of the nevus. Implications for clinical practice and future research are discussed.
Subjective Well-Being Among Unaccompanied Refugee Youth: Longitudinal Associations With Discrimination and Ethnic Identity Crisis
Authors: Oppedal Brit , Keles Serap , Røysamb Espen
Published: August 2022

Unaccompanied refugee youth (URY), who as children fled their countries to seek asylum in a foreign country without the company of an adult legal caretaker are described as being in a vulnerable situation. Many of them struggle with mental reactions to traumatic events experienced pre-migration, and to the daily hassles they face after being granted asylum and residence. Despite continuous high levels of mental health problems URY demonstrate remarkable agency and social mobility in the years after being granted asylum in their destination countries. A sense of subjective well-being (SWB) may enable resilient outcomes in people exposed to past or ongoing adversities. To fill the gap in the research literature about positive psychological outcomes among URY, the overall aim of this study was to explore the longitudinal associations between SWB and two taxing acculturation hassles: perceived discrimination and ethnic identity crisis. Three annual waves of self-report questionnaire data were collected from a population-based sample of URY; n = 581, Mage = 20.01(SD = 2.40), Mlength of stay = 4.63 (SD = 4.40), 82 % male, mainly from Afghanistan, Somalia, Iraq, and Sri Lanka. The longitudinal associations between SWB, perceived discrimination and ethnic identity crisis across time were analyzed using auto-regressive cross-lagged modeling. The results revealed that perceived discrimination, but not ethnic identity crisis, negatively predicted subsequent levels of SWB. More importantly, high levels of SWB at one timepoint predicted decreases in both discrimination and ethnic identity crisis at subsequent timepoints. Further, increases in SWB from one timepoint to the next was associated with significant co-occurring decreases in both discrimination and ethnic identity crisis, and vice versa. Despite the negative effect of perceived discrimination on SWB, promoting SWB in URY can protect them from future hazards of acculturation hassles in complex ways. We underscore the need for more research on SWB among URY and other refugee youth. We further discuss the potential of SWB to foster resilient outcomes in young refugees and suggest that interventions to strengthen SWB among them should consider their transnational and multicultural realities and experiences.
English as a foreign language teachers’ professional success in the Chinese context: The effects of well-being and emotion regulation
Authors: Fan Jian , Wang Yongliang
Published: August 2022

Given the significance of teachers’ professional success in the adequacy of education, exploring the determinants of this variable appears crucial. To address this need, this inquiry inspected the role of well-being and emotion regulation in Chinese EFL teachers’ professional success. For this purpose, 357 Chinese EFL teachers were selected to answer three pre-designed questionnaires. Structural equation modeling (SEM) using Smart-PLS was implemented to analyze teacher participants’ responses. The structural model revealed a strong, favorable connection between well-being, emotion regulation, and professional success. The model also demonstrated that both well-being and emotion regulation were highly influential in Chinese EFL teachers’ professional success. The potential implications for EFL teachers, teacher educators, and educational authorities are further discussed.
Exploring teachers’ attitudes and self-efficacy beliefs for implementing student self-assessment of English as a foreign language writing
Authors: Zhang Xiaoyu Sophia , Zhang Lawrence Jun , Parr Judy M. , Biebricher Christine
Published: August 2022

With the growing need to nurture students’ independent learning, English language teaching (ELT) practices should reflect student-centered assessment approaches, such as self-assessment, an ultimate goal of higher education. It has been pointed out that to conduct effective self-assessment, students need to be taught systematically, and that is where teachers are expected to step in. Prior to implementing such a change in ELT, it is important to conduct research on English as a foreign language (EFL) teachers’ attitudes toward, and self-efficacy beliefs about, implementing self-assessment to cultivate capable student self-assessors. Although the strong global endorsement of self-assessment over the past two decades has witnessed its classroom implementation in different disciplines, such studies are scant in relation to EFL writing classrooms. To address this gap, the present qualitative research examined five Chinese tertiary EFL writing teachers’ attitudes toward and self-efficacy beliefs about student self-assessment of writing, as well as possible reasons that discourage them from engaging students in self-assessment practices. Data collected from in-depth, semi-structured interviews indicated that self-assessment, a critical element of self-regulated learning, is surprisingly missing from the teachers’ knowledge base and previous practices. Additionally, the findings offer insights into the striking differences in teachers’ understanding of, attitudes toward, and low self-efficacy beliefs about self-assessment of writing. Reasons why teachers choose not to implement self-assessment of writing are also discussed. Findings from this study contribute to a deeper understanding of how EFL teachers’ attitudes and self-efficacy beliefs are enacted in relation to their classroom assessment practices in order to move forward discussions on the feasibility of implementing self-assessment of writing in tertiary EFL classrooms.
Paths to positive growth in parents bereaved by drug-related death: A mixed-method study
Authors: Titlestad Kristine Berg , Kristensen Pål , O'Connor Maja , Hystad Sigurd , Dyregrov Kari
Published: August 2022

Introduction

Drug-related deaths (DRDs) are a major public health challenge. Losing a child to a DRD can be a very stressful life event, which places parents at risk of mental and physical health problems. However, traumatic experiences like losing a child to DRD can paradoxically also lead to positive psychological changes. A mixed-method approach was used to understand the complexity of the phenomenon of post-traumatic growth experienced by parents following a DRD.

Method

By combining data from a survey (n = 89) and interviews (n = 14), we explored positive growth experiences among Norwegian parents. We conducted descriptive analyses of the sample’s demographic characteristics and mean scores for Post-traumatic Growth Inventory (PTGI-SF) items. Hierarchical multiple regression was used to examine the influence of the ability to perform daily activities (WSAS), self-efficacy (GSE-SF), social support (CSS), and symptoms of prolonged grief (PG-13) on the outcome variable of post-traumatic growth (PTGI-SF). Reflexive thematic analysis was applied to analyze the qualitative data. Finally, we integrated the results of the survey and the interviews.

Results

For items measuring post-traumatic growth, parents scored highest on the item “I discovered that I’m stronger than I thought I was” and lowest on the item “I am able to do better things with my life.” Self-efficacy and social support had a statistically significant relation with post-traumatic growth. Two themes were generated from the interviews: (I) new perspectives on life and (II) new paths in life. Even though the “New Possibilities” subscale had the lowest mean score for the PTGI-SF, new paths in life were important for many of the interviewed parents.

Discussion

Parents described traumatic stressors associated with having a child who uses narcotics and hence experienced positive changes even before losing their child. We argue that on an individual level, the consequences of spillover stigma, low self-efficacy, and intrusive rumination can hinder potential post-traumatic growth. On a group level, enhancing network support may increase post-traumatic growth experiences. Hence, parents who have experienced a DRD can benefit from help to activate their social networks and strengthen their self-efficacy.
Bilateral repetitive transcranial magnetic stimulation ameliorated sleep disorder and hypothalamic–pituitary–adrenal axis dysfunction in subjects with major depression
Authors: Chen Xing , Jiang Fei , Yang Qun , Zhang Peiyun , Zhu Haijiao , Liu Chao , Zhang Tongtong , Li Weijun , Xu Jian , Shen Hongmei
Published: August 2022

Objective

In this study, we sought to explore the effectiveness of bilateral repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) on depressive symptoms and dysfunction of hypothalamic–pituitary–adrenal (HPA) axis in patients with major depressive disorder (MDD).

Materials and methods

One hundred and thirty-six adults with MDD were administrated drugs combined with 3 weeks of active rTMS (n = 68) or sham (n = 68) treatment. The 17-item Hamilton Depression Rating Scale for Depression (HAMD-17) was to elevate depression severity at baseline and weeks 4. To test the influence of rTMS on the HPA axis, plasma adrenocorticotropic hormone (ACTH) and serum cortisol (COR) were detected in pre- and post-treatment.

Results

No statistical significance was found for the baseline of sociodemographic, characteristics of depression, and psychopharmaceutical dosages between sham and rTMS groups (p > 0.05). There was a significant difference in the HAMD-17 total score between the two groups at end of 4 weeks after treatment (p < 0.05). Compared to the sham group, the rTMS group demonstrated a more significant score reduction of HAMD-17 and sleep disorder factor (HAMD-SLD) including sleep onset latency, middle awakening, and early awakening items at end of 4-week after treatment (p < 0.05). Furthermore, total score reduction of HAMD-17 was correlated with a decrease in plasma ACTH, not in COR, by rTMS stimulation (p < 0.05).

Conclusion

Bilateral rTMS for 3 weeks palliated depression via improvement of sleep disorder, and plasma ACTH is a predictor for the efficacy of rTMS, especially in male patients with MDD.
Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization
Authors: Yu Xing-Hao , Cao Rong-Rong , Yang Yi-Qun , Zhang Lei , Lei Shu-Feng , Deng Fei-Yan
Published: August 2022

Purpose

Osteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified.

Methods

Based on the large individual-level datasets from UK Biobank as well as GWAS summary datasets, we first constructed genetic risk scores (GRSs) for 308 of 486 human serum metabolites and evaluated the effect of each GRS on 2 major osteoporosis phenotypes, i.e., estimated bone miner density (eBMD) and fracture, respectively. Then, two-sample Mendelian Randomization (MR) was performed to validate the casual metabolites on osteoporosis. Multivariable MR analysis tested whether the effects of metabolites on osteoporosis are independent of possible confounders. Finally, we conducted metabolic pathway analysis for the metabolites involved in bone metabolism.

Results

We identified causal effects of 18 metabolites on eBMD and 1 metabolite on fracture with the GRS method after adjusting for multiple tests. Then, 9 of them were further validated with MR as replication, where comprehensive sensitive analyses proved robust of the causal associations. Although not identified in GRS, 3 metabolites were associated with at least three osteoporosis traits in MR results. Multivariable MR analysis determined the independent causal effect of several metabolites on osteoporosis. Besides, 23 bone metabolic pathways were detected, such as valine, leucine, isoleucine biosynthesis (p = 0.053), and Aminoacyl-tRNA biosynthesis (p = 0.076), and D-glutamine and D-glutamate metabolism (p = 0.004).

Conclusions

The systematic causal analyses strongly suggested that blood metabolites have causal effects on osteoporosis risk.
The detection rate and influencing factors of high-risk groups of cardiovascular disease in Anhui, China: A cross-sectional study of 99,821 residents
Authors: Xing Xiu-Ya , Wang Zhi-Xin , Cao Ya-Wen , Wang Xin-Yi , Zhang Luan , Chen Ye-Ji , Wang Hua-Dong , Xu Jing-Qiao , Niu Mi-Xue , Liu Zhi-Rong , Tao Sha-Sha
Published: August 2022

Objective

To investigate the detection rate and influencing factors of high-risk population of cardiovascular disease in Anhui province.

Methods

From March 2017 to August 2019, the residents aged 35–75 years old were selected using the multi-stage stratified cluster sampling method in 8 counties and districts of Anhui Province, and questionnaire survey, anthropometric measurement, and collection of biological samples were carried out among them.

Results

A total of 99,821 residents in Anhui Province were finally investigated, and among them 21,426 residents were detected to be high-risk groups of cardiovascular disease. The detection rate of high-risk groups was 21.46%. According to the high-risk types, the high-risk groups can be clustered. 74.57% of them had only one high-risk type, 22.57% of them had two high-risk types, and 2.86% had three or more high-risk types. The results of Generalized Linear Mixed Model (GLMM) showed that male, age ≥45 years old, not married, occupation as a farmer, annual family income <25,000 yuan, drinking, overweight and obesity, pre-central obesity and central obesity, snoring, feeling fatigued, sleepiness, and self-reported history of diabetes were more likely to be risk factors of cardiovascular disease (all P value < 0.05).

Conclusion

The detection rate of high-risk groups of cardiovascular disease in Anhui Province is relatively high. Individualized intervention measures as well as comprehensive prevention and control strategies should be adopted focusing on the distribution characteristics of risk factors of high-risk groups.
Variability of body mass index and risks of prostate, lung, colon, and ovarian cancers
Authors: Sun Yangyang , Zhou Lingling , Shan Tao , Ouyang Qiong , Li Xu , Fan Yuanming , Li Ying , Gong Hang , Alolga Raphael N. , Ma Gaoxiang , Ge Yuqiu , Zhang Heng
Published: August 2022

Objective

We investigated the association between cancer incidence and body mass index (BMI) variability calculated from the recall of weight at decades of age by participants in the USA Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Methods

A total of 89,822 individuals' BMI were recorded as recalled the participant's aged 30, 40, 50, 60, 70 years, and baseline. BMI variability was assessed using four indices: SD, coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV). The multivariate Cox regression analysis was performed to calculate hazard ratios (HRs) of these measures for incident cancers and corresponding 95% CIs.

Results

During the median follow-up of 11.8 years, there were newly diagnosed 5,012 cases of prostate cancer, 792 cases of lung cancer, 994 cases of colon cancer, and 132 cases of ovarian cancer. Compared with the lowest quartile (Q1) group, the highest quartile (Q4) group of BMI variability indices was associated with increased lung cancer risk, including BMI_SD (HR, 1.58; 95% CI, 1.17–2.12), BMI_CV (HR, 1.46; 95% CI, 1.10–1.94), BMI_VIM (HR, 1.73; 95% CI, 1.33–2.25), and BMI_ARV (HR, 2.17; 95% CI, 1.62–2.91). Associations between BMI variability and prostate, colon, and ovarian cancer incidences were of limited significance.

Conclusion

The findings imply that maintaining a stable weight across adulthood is associated with a decreased incidence of lung cancer.
Fall risks and the related factors for the homebound older people with dementia: Evidence from East China
Authors: Dong Xiaoxin , Liu Guanjun , Yin Xiaoxu , Min Rui , Hu Yueming
Published: August 2022

Purpose

Falls are a major public health problem, especially for older people. This research aimed to provide a direct illustration of fall risks among the homebound older people with dementia in China, and to identify the risk factors associated with it.

Methods

In 2020, a questionnaire-based field survey was used to assess 1,042 people aged over 60 years in Ningbo, Eastern China. The Morse Fall Risk Scale's result was employed as the dependent variable, while the basic health problems, living environment difficulties, social support problems, and behavioral awareness issues were utilized as the independent variables; subsequently, chi-squared tests and four multivariate ordinarily ordered logistic regression models were performed.

Results

Overall, nine hundred and thirty-one older people with dementia were included in this study (the effective rate was 89.34%), with the majority of them having severe dementia (27.9%). Furthermore, 16.2% had fallen in the past 3 months, and 16.8% were at a high risk of falling. The risk factors for the older people's cognitive function included 80–90 years old, vascular dementia, marital status, and history of falls (P < 0.05); the kinds of chronic diseases, the activities of daily living, living environment, caregiver burden, caregiver knowledge, the Cohen Mansfield Agitation Inventory results, and the Clinical Dementia Rating were the protective factors for the risk of falls in them (P < 0.05).

Conclusion

The risk of falling of the Chinese homebound older people with dementia was high. Their caregivers, such as relatives, need to pay attention to these risk factors and perform appropriate measures to prevent falls.
Grandchild care, inadequate medical insurance protection, and inequalities in socioeconomic factors exacerbate childhood obesity in China
Authors: Yang Jing , Shen Yun , Deng Yue , Liao Zangyi
Published: August 2022

This study examines the influences of grandchild care and medical insurance on childhood obesity. Nationally representative longitudinal data—from the China Family Panel Studies 2010–2020—of 26,902 school-age children and adolescents aged 6–16 years and China's new reference standard (“WS/T586-2018”) are used to identify a child's obesity status. Using binary mixed-effects logistic regression models and the Blinder–Oaxaca decomposition method, this study explores the roots of obesity inequalities and finds that at least 15% of Chinese children aged 6–16 were obese in the 2010s. The logistic regression analysis results indicate that grandchild care, public medical insurance, and commercial medical insurance are key risk factors of child obesity. However, the influences are heterogeneous in different groups: Grandchild care and public medical insurance increase urban–rural obesity inequalities because of a distribution effect, and grandchild care may also exacerbate children obesity inequalities between left-behind and non-left-behind children owing to the event shock of parental absence. Inequalities in socioeconomic status (SES) factors such as income, education, and region also cause obesity inequalities. These results indicate that child obesity and its inequalities are rooted in multidimensional environmental inequalities, including medical protection policies and its benefit incidence; intergenerational behavior and family SES factors; and urban–rural and left-behind risk shocks. This study provides new evidence for the development of population-based interventions and equitable medical insurance policies to prevent the deterioration of child obesity among Chinese school-age children and adolescents.
Multi-sector stakeholder's perceptions of determinants of successful implementation of a pediatric weight management intervention
Authors: Persaud Alicia , Castro Ines , Simione Meg , Smith Justin D. , O'Connor Giselle , Sharifi Mona , Perkins Meghan , Torres Shioban , Taveras Elsie M. , Kuhlthau Karen , Fiechtner Lauren
Published: August 2022

Background

Multi-sector stakeholder engagement is essential in the successful implementation, dissemination, and sustainability of pediatric weight management interventions (PWMI), particularly in low-income settings where sustainability relies on external policies and reimbursement. The objective of this study was to engage stakeholders (1) to inform the creation of the intervention with adaptations needed for a successful PWMI in a primary care and community setting and (2) to identify barriers and facilitators to implementation and dissemination.

Methods

We sought to examine the perspectives of local, state, and national clinic and community stakeholders during the pre-implementation period of a two-arm, randomized trial of a Health Weight Clinic PWMI conducted in two health centers and a modified—Healthy Weight and Your Child PWMI at two local YMCAs that serve a predominantly lower income, Hispanic community. The Consolidated Framework for Implementation Research interview guide served as a template for the study but was modified to fit the PWMIs and the various professional roles. Interviews were transcribed and analyzed using the framework analysis approach and themes were linked to the CFIR domains and constructs.

Results

Twenty-six stakeholders perceived the following as needed components of a PWMI: a formal curriculum with illustrative examples, a patient- and family-centered program, group visits, and high-quality multidisciplinary personnel. These findings led to the creation of a group visit curriculum, implementation trainings and cross-site collaborative technical assistance. Additionally, creating partnerships between community and clinical organizations, and addressing patient barriers and unmet social needs (i.e., transportation, food) were identified as facilitators to successful implementation. These results led to the creation of community resource guides, connections to community organizations, and screening and referring for unmet social needs. Perceived facilitators of dissemination included proving cost-effectiveness of the PWMI to inform insurance reimbursement for long-term sustainability. Therefore, we collected cost data and engaged with Medicaid officials to discuss reimbursement.

Conclusion

Findings highlight the importance of engaging multi-sector stakeholders pre-implementation to ensure the components valued are included, ensuring the program minimizes barriers to participation, considering how staff training can improve implementation and how collected outcomes can inform sustainability and dissemination of PWMIs in clinic and community settings.
Comparative studies of deep learning segmentation models for left ventricle segmentation
Authors: Shoaib Muhammad Ali , Lai Khin Wee , Chuah Joon Huang , Hum Yan Chai , Ali Raza , Dhanalakshmi Samiappan , Wang Huanhuan , Wu Xiang
Published: August 2022

One of the primary factors contributing to death across all age groups is cardiovascular disease. In the analysis of heart function, analyzing the left ventricle (LV) from 2D echocardiographic images is a common medical procedure for heart patients. Consistent and accurate segmentation of the LV exerts significant impact on the understanding of the normal anatomy of the heart, as well as the ability to distinguish the aberrant or diseased structure of the heart. Therefore, LV segmentation is an important and critical task in medical practice, and automated LV segmentation is a pressing need. The deep learning models have been utilized in research for automatic LV segmentation. In this work, three cutting-edge convolutional neural network architectures (SegNet, Fully Convolutional Network, and Mask R-CNN) are designed and implemented to segment the LV. In addition, an echocardiography image dataset is generated, and the amount of training data is gradually increased to measure segmentation performance using evaluation metrics. The pixel's accuracy, precision, recall, specificity, Jaccard index, and dice similarity coefficients are applied to evaluate the three models. The Mask R-CNN model outperformed the other two models in these evaluation metrics. As a result, the Mask R-CNN model is used in this study to examine the effect of training data. For 4,000 images, the network achieved 92.21% DSC value, 85.55% Jaccard index, 98.76% mean accuracy, 96.81% recall, 93.15% precision, and 96.58% specificity value. Relatively, the Mask R-CNN outperformed other architectures, and the performance achieves stability when the model is trained using more than 4,000 training images.
Comparing the effectiveness of continuous subcutaneous insulin infusion with multiple daily insulin injection for patients with type 1 diabetes mellitus evaluated by retrospective continuous glucose monitoring: A real-world data analysis
Authors: Keyu Guo , Jiaqi Li , Liyin Zhang , Jianan Ye , Li Fan , Zhiyi Ding , Qin Zhou , Xia Li , Lin Yang , Zhiguang Zhou
Published: August 2022

Objective

Regarding the effects and practical application of insulin pumps on patients with type 1 diabetes mellitus (T1DM), the real-world evidence is limited especially concerning the incidence of hypoglycemia. This study aimed to compare the efficacy of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy on glycemic metrics evaluated by retrospective continuous glucose monitoring (CGM) in Chinese patients with T1DM.

Methods

In total, 362 T1DM Chinese patients from the outpatient department of the Second Xiangya Hospital, Central South University, who underwent intensive insulin therapy and used a retrospective CGM system were included in this retrospective cross-sectional study. Comprehensive analysis of clinical and biological features and retrospective CGM derived-metrics was performed on the 362 enrolled T1DM patients who underwent CSII (n = 61) or MDI (n = 301) therapy (defined as 4 or more insulin injections per day).

Results

Our findings demonstrated that patients who underwent CSII therapy, compared with those who received MDI therapy, had lower levels of hemoglobin A1c (HbA1c) and fasting blood glucose; moreover, CSII therapy was associated with better glycemic outcomes in terms of increasing time in range (TIR), decreasing time above range (TAR), and achieving CGM-associated targets of TIR ≥70% and TAR <25%. However, patients who underwent CSII therapy did not experience decreasing time below range (TBR), achieving CGM-associated targets of TBR <4%, and reduction of the risk of hypoglycemia as evidenced by comparing TBR and low blood glucose index (LBGI) between the two treatment regimens. The parameters of glycemic variability, such as standard deviation of glucose (SD), mean amplitude glycemic excursion (MAGE), and large amplitude glycemic excursion (LAGE) in T1DM patients who underwent CSII therapy outperformed.

Conclusion

Our results provided further evidence that CSII therapy is safe and effective for management of Chinese T1DM patients, which was confirmed by a lower HbA1c level and better CGM-derived metrics but no demonstration of improvment in the risk of hypoglycemia. To achieve more satisfactory glycemic outcomes through the utilization of CSII therapy for Chinese T1DM patients, a strong physician-patient relationship is essential.
Chinese elderly migrants' loneliness, anxiety and depressive symptoms: The mediation effect of perceived stress and resilience
Authors: Wang Hao , Hou Yanjie , Zhang Lin , Yang Man , Deng Ruyue , Yao Jun
Published: August 2022

Elderly migrants who face the dual challenges of aging and migration are more likely to suffer psychological disorders. Existing research has demonstrated a link between loneliness and psychological disorders in the general elderly population. However, we know little about the relationships among elderly migrants, and the psychological mechanisms linking them. This study aims to examine the effects of loneliness on anxiety and depressive symptoms among Chinese elderly migrants, and explore the mediating roles of perceived stress and resilience. All 654 participants were recruited in Nanjing, Jiangsu Province, China. Results showed that loneliness was significantly correlated with anxiety and depressive symptoms (p < 0.001). Perceived stress and resilience mediated the relationship between loneliness and anxiety symptoms. The mediating effect of perceived stress was 0.128 (Bootstrap 95% CI: 0.092–0.168, Ratio = 37.4%). Resilience was 0.026 (Bootstrap 95% CI: 0.005–0.049, Ratio = 7.6%). Furthermore, perceived stress and resilience also mediated the relationship between loneliness and depressive symptoms. The mediating effects were 0.111 and 0.043, respectively (Bootstrap 95% CI: 0.073–0.151, Ratio = 27.9%; Bootstrap 95% CI: 0.020–0.069, Ratio = 10.8%). All the mediating effects were significant because the bootstrap 95% CIs did not contain zero. Overall, our findings suggested that loneliness not only can directly influence elderly migrants' anxiety and depressive symptoms but also by increasing perceived stress or decreasing resilience.
Envisioning social drones in education
Authors: Johal Wafa , Gatos Doğa , Yantac Asim Evren , Obaid Mohammad
Published: August 2022

Education is one of the major application fields in social Human-Robot Interaction. Several forms of social robots have been explored to engage and assist students in the classroom environment, from full-bodied humanoid robots to tabletop robot companions, but flying robots have been left unexplored in this context. In this paper, we present seven online remote workshops conducted with 20 participants to investigate the application area of Education in the Human-Drone Interaction domain; particularly focusing on what roles a social drone could fulfill in a classroom, how it would interact with students, teachers and its environment, what it could look like, and what would specifically differ from other types of social robots used in education. In the workshops we used online collaboration tools, supported by a sketch artist, to help envision a social drone in a classroom. The results revealed several design implications for the roles and capabilities of a social drone, in addition to promising research directions for the development and design in the novel area of drones in education.