bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Application of an Integrated Site Remediation Technology Mix Method Based on Site Contaminant Distribution Characteristics
Authors: Zhang Min , Yang Shuai , Zhang Zhifei , Guo Caijuan , Xie Yan , Wang Xinzhe , Sun Lin , Ning Zhuo
Published: October 2023

Millions of contaminated sites worldwide need to be remediated to protect the environment and human health. Although numerous remediation technologies have been developed, selecting optimal technologies is challenging. Several multiple criteria decision-making methods for screening the optimal remediation technology have been proposed, but they mostly focus on a specific area rather than the whole contaminated site. In recent years, the “contamination source control—process blocking—in situ remediation” technology mix model has gradually gained high appreciation. Nevertheless, the screening of technologies within each chain of this model relies heavily on arbitrary personal experience. To avoid such arbitrariness, a petroleum-contaminated site containing light non-aqueous phase liquids (LNAPLs) was used as an example, and a scientific screening and combination procedure was developed in this study by considering the distribution characteristics of contaminants. Through the procedure, a technology mix, which includes institutional control, risk monitoring, emergency response, multiphase extraction, interception ditch, monitoring of natural attenuation, hydrodynamic control, as well as some alternative technologies, was found, aiming at different locations and strata. The clear spatial relationship concept promises to enhance the effectiveness of contaminated site remediation. The proposed method only gave us a technical framework and should be tested and enriched in future studies.
Optimization of Drying Kinetics and Stone Milling of Chickpea (Cicer arietinum): An Investigation of Moisture Content and Milling Speed Effects on Mill Operative Parameters, Particle Size Distribution, and Flour Composition
Authors: Cappelli Alessio , Zaninelli Mauro , Cividino Sirio , Fiscella Mattia , Cini Enrico , Parenti Alessandro , Masella Piernicola
Published: October 2023

Chickpeas are one of the most widely consumed legumes in the world. Nevertheless, the literature is lacking studies on the effect of drying and milling processes on chickpea flour characteristics, thus motivating this work. The first aim of this work is to improve chickpea drying process through an in-depth evaluation of drying kinetics; the second aim is to assess the effects of three different moisture contents (8, 10, and 12%) and three milling speeds (120, 220, and 320 RPM) on operative milling parameters, particle size distribution, and flour composition. Our results highlight that moisture content and stone rotational speed have statistically significant effects on milling operative parameters, flour particle size, and chickpea flour composition. As stone rotational speed increases, flour temperature (∆T), average power, and damaged starch content significantly increases. On the other hand, as moisture content increases, energy consumption and specific milling energy increases, while starch and protein content significantly decrease. The results of this study recommend, for the first time in the literature, optimal values of moisture content and milling speed of chickpea. In conclusion, milling chickpeas with 10% moisture content at 320 RPM (milling speed) seems to be the best compromise between milling operative parameters, particle size, and chickpea flour composition.
A Parameter Self-Tuning Decoupling Controller Based on an Improved ADRC for Tension Systems
Authors: Ju Guoli , Liu Shanhui , Wei Keliang , Ding Haodi , Wang Chaoyue
Published: October 2023

Aiming at the problems of strong coupling and time-varying parameters in the tension systems of roll-to-roll coating machines, this paper outlines the design of a parameter self-tuning decoupling controller based on an improved active disturbance rejection controller (ADRC) for tension systems. First, we established a nonlinear coupled model for a global tension system based on the roll-to-roll coating machine tension constituent unit and working principle. Second, we introduced virtual quantities and actual control quantities; then, we applied an ADRC for decoupling control of the tension system based on a nonlinear coupling model, using a genetic algorithm (GA) to achieve parameters tuning in the ADRC. Finally, both the traditional proportional–integral–differential (PID) controller and the designed controller were simulated to evaluate their anti-interference and decoupling performance. Furthermore, the performances of several controllers were compared to the results obtained by other researchers. The result found that the parameter self-tuning decoupling controller based on an improved ADRC for tension systems exhibited better decoupling control performance and that the controller was able to achieve precise control of tension.
The Development of a Novel Direct-Expansion Ground Source Heat Pump (DE-GSHP) for Embankment Heating in Cold Regions
Authors: Cao Mingxing , Zhang Yimin , Hu Tianfei
Published: October 2023

This study aimed to investigate the practical applications of a ground source heat pump (GSHP) system for heating applications in embankment engineering. A special direct-expansion GSHP (DE-GSHP) was designed and manufactured, and its performance was experimentally assessed. Subsequently, the newly developed DE-GSHP structure demonstrated an excellent heating performance with respect to positive heat-supplying temperatures in cold regions. The temperature could be automatically controlled at 30, 45, 60, and 75; additionally, the heat-absorbing temperatures were maintained below 0 °C, which was extremely lower than that of the deep frost-free stratum. Further, the experimental data were used to evaluate the coefficient of performance of the DE-GSHP, which was more than 3.5. The findings indicated that the GSHP has potential applications for embankment heating in cold regions.
New Trends in Efficient Buildings
Authors: Salamone Francesco , Belussi Lorenzo , Danza Ludovico , Guarino Francesco , Longo Sonia
Published: October 2023

The literature reports several examples wherein calculation methodologies for assessing the energy performance of buildings are proposed, and solutions to improve their performance are posited, along with the introduction of advanced technologies and algorithms to reach this goal [...]
Special Issue on Propolis and Other Bee Products: Beneficial Effects on Health and Processing Technology
Authors: Kurek-Górecka Anna , Rzepecka-Stojko Anna , Górecki Michał , Otręba Michał
Published: October 2023

Bee products are some of the most useful natural products and are favoured by natural medicine scientists for their possible pluripotent nutritional and biotic applications [...]
Augmented Reality-Assisted Surgical Exposure of an Impacted Tooth: A Pilot Study
Authors: Macrì Monica , D’Albis Giuseppe , D’Albis Vincenzo , Timeo Simona , Festa Felice
Published: October 2023

Three-dimensional radiological evaluation through cone beam computer tomography is essential in diagnosing and establishing proper surgical management in impacted teeth. Through Augmented Reality (AR), clinicians have the opportunity to use three-dimensional computer-generated radiologic information to visualise the patient and simultaneously the superimposition of his internal structures. Here, we describe a digital workflow to assist the oral surgeon in pre-orthodontic exposure of a vestibular impacted canine using AR. The AR hardware consists of a camera and a traditional stand-up monitor. The registration and tracking are video-based and marker-free, with an automatic pose estimation obtained through VisLab 20.10.1AR software algorithm’s object recognition and tracking approach. A 3D model is created by combining the anterior teeth taken from the intraoral scan with the same teeth plus the included tooth taken from the CBCT segmentation. The 3D file is uploaded into the AR software. Model tracking is straightforward to set up without prior registration of targets or surroundings. The AR information is used successfully to define the surgical access to perform flap and osteotomy. The accuracy of model tracking matching was calculated constantly by the software. During the tracking, the process recorded an inlier ratio of 0.39:0.48. Further studies and clinical trials will evaluate the value of this novel technology in the management of impacted teeth.
Relevance of Surface Electromyography Assessment and Sleep Impairment in Scoliosis: A Pilot Study
Authors: Piele Denisa , Ilie Eva , Rusu Ligia , Marin Mihnea Ion
Published: October 2023

Background: According to statistics, worldwide, the number of young persons diagnosed with idiopathic scoliosis has tripled in the last 10 years. This tendency seems to be related to the development of technological devices that induce vicious postures. Specialized literature shows that the predicted evolution will lead to a tripling of the population affected by scoliosis by 2050. Associated complications can be most varied, with functional or respiratory and cardiac impairment being the most severe. The purpose of this study is to objectify the effect of associating Schroth therapy with general elements of global postural reeducation (GPR) therapy in the treatment of scoliosis using electromyography, scoliosis assessment scales, and sleep quality evaluation. The present study is addressed to scoliotic patients. Methods: In order to assess the muscle imbalance installed in scoliosis, we have used SEMG, while Epworth, Baecke, and SAQ scales assessed sleepiness, physical activity levels, and self-perception of the scoliotic patient. Results: After performing a therapeutic protocol that combines Schroth and global postural reeducation (GPR) exercises, an improvement of the functional status was observed for the scoliotic patients. The statistical analysis presents a favorable symmetry index during flexion (p = 0.042), a significant difference in the Epworth score (p = 0.002), as well as a significant difference in the SAQ2 score (p = 0.049). Conclusion: Early detection of scoliosis prevents functional degradation. On the other hand, developing an adequate therapeutic protocol leads to an improved functional status and increased life quality.
(De)Linking with the Past through Memorials
Authors: Zaninović Tamara , Omićević Nerma , Bojanić Obad Šćitaroci Bojana
Published: October 2023

Numerous examples of urban, architectural, and landscape projects indicate global and continuous interest in memorial design without a comparative study of their contextual similarities and differences. There is no clear terminological and conceptual framework of how memorials are designed nor if they are perceived as diverse types of public places. This research combines multiple results of extensive and on-going research on memorials as places for people to reconnect with past events, circumstances, or persons, with the aim of building a theoretical and conceptual framework within the domain of architectural and urban design. The main question is how the design of memorials achieves remembrance as well as healing of both places and communities through conciliation, mediation, forgetting, learning, and planning new concepts for future urban development. The term (de)linking with the past is proposed for describing the importance of achieving these various memorial functions. The resulting dualistic conceptual framework of memorials includes eleven design principles based on models and methods of spatial interventions which can enable communities to move forward from traumatic events and negative emotions towards building a basis for a better future by learning from the past.
The Fingerprints of Periodic Electric Fields on Line Shapes Emitted in Plasmas
Authors: Hannachi Ibtissem , Stamm Roland
Published: October 2023

Periodic electric fields are found in many kinds of plasmas and result from the presence of collective fields amplified by plasma instabilities, or they are created by external sources such as microwave generators or lasers. The spectral lines emitted by atoms or ions in a plasma exhibit a frequency profile characteristic of plasma conditions, such as the temperature and density of charged particles. The fingerprints of periodic electric fields appear clearly on the line shape for a large range of frequencies and magnitudes of the oscillating electric field. Satellite structures appear near to multiples of the oscillation frequency and redistribute the intensity of the line far from the line center. The modeling of the simultaneous effects of the plasma microfield and of a periodic electric field has been active since the seventies, but it remains difficult to be conducted accurately since the quantum emitter is submitted to several time-dependent electric fields, each with their own characteristic time. We describe here a numerical approach which couples a simulation of the motion of charged plasma particles with an integration of the emitter Schrödinger equation. Resulting hydrogen line shapes are presented for different plasmas and periodic fields encountered in laboratory and astrophysical plasmas.
Contemporary Art Authentication with Large-Scale Classification
Authors: Dobbs Todd , Nayeem Abdullah-Al-Raihan , Cho Isaac , Ras Zbigniew
Published: October 2023

Art authentication is the process of identifying the artist who created a piece of artwork and is manifested through events of provenance, such as art gallery exhibitions and financial transactions. Art authentication has visual influence via the uniqueness of the artist’s style in contrast to the style of another artist. The significance of this contrast is proportional to the number of artists involved and the degree of uniqueness of an artist’s collection. This visual uniqueness of style can be captured in a mathematical model produced by a machine learning (ML) algorithm on painting images. Art authentication is not always possible as provenance can be obscured or lost through anonymity, forgery, gifting, or theft of artwork. This paper presents an image-only art authentication attribute marker of contemporary art paintings for a very large number of artists. The experiments in this paper demonstrate that it is possible to use ML-generated models to authenticate contemporary art from 2368 to 100 artists with an accuracy of 48.97% to 91.23%, respectively. This is the largest effort for image-only art authentication to date, with respect to the number of artists involved and the accuracy of authentication.
Current Techniques for Fruit Juice and Wine Adulterant Detection and Authentication
Authors: Mac Hoa Xuan , Pham Thanh Tung , Ha Nga Thi Thanh , Nguyen Lien Le Phuong , Baranyai László , Friedrich László
Published: October 2023

Fruit juice and wine are important beverages that are consumed all over the world. Due to their constantly increasing demand and high value, fruit juice and wine are one of the most frequent targets of adulteration. Since adulterated foods are proven to have harmful effects on health, several approaches have been utilized for the detection of fruit juice and wine adulteration. Based on the requirement for sample destruction, analytical techniques to assess food authenticity can be classified into 2 main categories, i.e., destructive and non-destructive techniques. This paper provides an overview on the principle of adulteration detection, its application and performance, and the advantages and limitations of various analytical techniques. Destructive approaches, such as physicochemical methods, isotope analysis, elemental analysis, chromatographic techniques, and DNA-based techniques, are reviewed. Furthermore, non-destructive approaches, including spectroscopic-based techniques, nuclear magnetic resonance spectroscopic technique, electronic techniques, and imaging-based techniques, are discussed.
The Development and Biomechanical Analysis of an Allograft Interference Screw for Anterior Cruciate Ligament Reconstruction
Authors: Lifka Sebastian , Rehberger Yannik , Pastl Klaus , Rofner-Moretti Alexander , Reichkendler Markus , Baumgartner Werner
Published: October 2023

Graft fixation during cruciate ligament reconstruction using interference screws is a common and frequently used surgical technique. These interference screws are usually made of metal or bioabsorbable materials. This paper describes the development of an allograft interference screw from cortical human bone. During the design of the screw, particular attention was paid to the choice of the screw drive and the screw shape, as well as the thread shape. Based on these parameters, a prototype was designed and manufactured. Subsequently, the first biomechanical tests using a bovine model were performed. The test procedure comprised a torsion test to determine the ultimate failure torque of the screw and the insertion torque during graft fixation, as well as a pull-out test to asses the ultimate failure load of the graft fixation. The results of the biomechanical analysis showed that the mean value of the ultimate failure torque was 2633 Nmm, whereas the mean occurring insertion torque during graft fixation was only 1125 Nmm. The mean ultimate failure load of the graft fixation was approximately 235 N. The results of this work show a good overall performance of the allograft screw compared to conventional screws, and should serve as a starting point for further detailed investigations and studies.
Mechanical Fractionation of Adipose Tissue—A Scoping Review of Procedures to Obtain Stromal Vascular Fraction
Authors: Schipper Jan , van Laarhoven Constance , Schepers Rutger , Tuin A. , Harmsen Marco , Spijkervet Fred , Jansma Johan , van Dongen Joris
Published: October 2023

Clinical indications for adipose tissue therapy are expanding towards a regenerative-based approach. Adipose-derived stromal vascular fraction consists of extracellular matrix and all nonadipocyte cells such as connective tissue cells including fibroblasts, adipose-derived stromal cells (ASCs) and vascular cells. Tissue stromal vascular fraction (tSVF) is obtained by mechanical fractionation, forcing adipose tissue through a device with one or more small hole(s) or cutting blades between syringes. The aim of this scoping review was to assess the efficacy of mechanical fractionation procedures to obtain tSVF. In addition, we provide an overview of the clinical, that is, therapeutic, efficacy of tSVF isolated by mechanical fraction on skin rejuvenation, wound healing and osteoarthritis. Procedures to obtain tissue stromal vascular fraction using mechanical fractionation and their associated validation data were included for comparison. For clinical outcome comparison, both animal and human studies that reported results after tSVF injection were included. We categorized mechanical fractionation procedures into filtration (n = 4), centrifugation (n = 8), both filtration and centrifugation (n = 3) and other methods (n = 3). In total, 1465 patients and 410 animals were described in the included clinical studies. tSVF seems to have a more positive clinical outcome in diseases with a high proinflammatory character such as osteoarthritis or (disturbed) wound healing, in comparison with skin rejuvenation of aging skin. Isolation of tSVF is obtained by disruption of adipocytes and therefore volume is reduced. Procedures consisting of centrifugation prior to mechanical fractionation seem to be most effective in volume reduction and thus isolation of tSVF. tSVF injection seems to be especially beneficial in clinical applications such as osteoarthritis or wound healing. Clinical application of tSVF appeared to be independent of the preparation procedure, which indicates that current methods are highly versatile.
Germination of Pisum sativum L. Seeds Is Associated with the Alternative Respiratory Pathway
Authors: Rodrigues Lénia , Nogales Amaia , Nunes João , Rodrigues Leonardo , Hansen Lee D. , Cardoso Hélia
Published: October 2023

The alternative oxidase (AOX) is a ubiquinol oxidase with a crucial role in the mitochondrial alternative respiratory pathway, which is associated with various processes in plants. In this study, the activity of AOX in pea seed germination was determined in two pea cultivars, ‘Maravilha d’América’ (MA) and ‘Torta de Quebrar’ (TQ), during a germination trial using cytochrome oxidase (COX) and AOX inhibitors [rotenone (RT) and salicylic hydroxamic acid (SHAM), respectively]. Calorespirometry was used to assess respiratory changes during germination. In both cultivars, SHAM had a greater inhibitory effect on germination than RT, demonstrating the involvement of AOX in germination. Although calorespirometry did not provide direct information on the involvement of the alternative pathway in seed germination, this methodology was valuable for distinguishing cultivars. To gain deeper insights into the role of AOX in seed germination, the AOX gene family was characterized, and the gene expression pattern was evaluated. Three PsAOX members were identified—PsAOX1, PsAOX2a and PsAOX2b—and their expression revealed a marked genotype effect. This study emphasizes the importance of AOX in seed germination, contributing to the understanding of the role of the alternative respiratory pathway in plants.
Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review
Authors: Orsini Francesco , Crotti Chiara , Cincinelli Gilberto , Di Taranto Raffaele , Amati Andrea , Ferrito Matteo , Varenna Massimo , Caporali Roberto
Published: October 2023

Several rheumatologic diseases are primarily distinguished by their involvement of bone tissue, which not only serves as a mere target of the condition but often plays a pivotal role in its pathogenesis. This scenario is particularly prominent in chronic inflammatory arthritis such as rheumatoid arthritis (RA) and spondyloarthritis (SpA). Given the immunological and systemic nature of these diseases, in this review, we report an overview of the pathogenic mechanisms underlying specific bone involvement, focusing on the complex interactions that occur between bone tissue’s own cells and the molecular and cellular actors of the immune system, a recent and fascinating field of interest defined as osteoimmunology. Specifically, we comprehensively elaborate on the distinct pathogenic mechanisms of bone erosion seen in both rheumatoid arthritis and spondyloarthritis, as well as the characteristic process of aberrant bone formation observed in spondyloarthritis. Lastly, chronic inflammatory arthritis leads to systemic bone involvement, resulting in systemic bone loss and consequent osteoporosis, along with increased skeletal fragility.
Enabling mRNA Therapeutics: Current Landscape and Challenges in Manufacturing
Authors: Youssef Maryam , Hitti Cynthia , Puppin Chaves Fulber Julia , Kamen Amine A.
Published: October 2023

Recent advances and discoveries in the structure and role of mRNA as well as novel lipid-based delivery modalities have enabled the advancement of mRNA therapeutics into the clinical trial space. The manufacturing of these products is relatively simple and eliminates many of the challenges associated with cell culture production of viral delivery systems for gene and cell therapy applications, allowing rapid production of mRNA for personalized treatments, cancer therapies, protein replacement and gene editing. The success of mRNA vaccines during the COVID-19 pandemic highlighted the immense potential of this technology as a vaccination platform, but there are still particular challenges to establish mRNA as a widespread therapeutic tool. Immunostimulatory byproducts can pose a barrier for chronic treatments and different production scales may need to be considered for these applications. Moreover, long-term storage of mRNA products is notoriously difficult. This review provides a detailed overview of the manufacturing steps for mRNA therapeutics, including sequence design, DNA template preparation, mRNA production and formulation, while identifying the challenges remaining in the dose requirements, long-term storage and immunotolerance of the product.
Immunohistochemical Assessment of Microvessel Density in OSCC: Spatial Heterogeneity of Angiogenesis and Its Impact on Survival
Authors: Mamilos Andreas , Lein Alexander , Winter Lina , Haas Markus , Reichert Torsten E. , Ettl Tobias , Künzel Julian , Spanier Gerrit , Brochhausen Christoph
Published: October 2023

(1) Background Oral squamous cell carcinomas (OSCC) are a common malignancy of the oral cavity and are often diagnosed when they have already spread to the regional lymph nodes. Advanced stages of cancer are characterized by the development of distant metastases. Angiogenesis, a hallmark of cancer, is known to contribute to cancer progression and metastasis. High microvessel density (MVD) has been linked to poor clinical outcomes in various types of cancer. (2) Methods: In this study, we aimed to investigate the spatial heterogeneity of blood vessels by comparing the tumor center and invasion front and to evaluate its prognostic value in OSCC. A total of 71 OSCC patient specimens were collected. The tissue was immunohistochemically stained using CD31 antibody to assess the MVD in the tumor center and the invasion front. Furthermore, the associations between the histopathological parameters, including MVD, disease-free survival (DFS), and overall survival (OS) were computed. (3) Results: In our study, we found a significantly higher presence of blood vessels at the invasion front of OSCCs compared to the tumor center. However, we did not observe any significant differences in MVD between different tumor stages. High intratumoral MVD was shown to be a positive prognostic factor for DFS (p = 0.047). (4) Conclusions: To the best of our knowledge, we were the first to analyze MVD as a prognostic factor by considering its spatial heterogeneity in OSCC. However, further studies are warranted to further elucidate the complexity of microvascular spatial heterogeneity and its influence on prognosis.
Advances in Recombinant Adeno-Associated Virus Vectors for Neurodegenerative Diseases
Authors: Li Leyao , Vasan Lakshmy , Kartono Bryan , Clifford Kevan , Attarpour Ahmadreza , Sharma Raghav , Mandrozos Matthew , Kim Ain , Zhao Wenda , Belotserkovsky Ari , Verkuyl Claire , Schmitt-Ulms Gerold
Published: October 2023

Recombinant adeno-associated virus (rAAV) vectors are gene therapy delivery tools that offer a promising platform for the treatment of neurodegenerative diseases. Keeping up with developments in this fast-moving area of research is a challenge. This review was thus written with the intention to introduce this field of study to those who are new to it and direct others who are struggling to stay abreast of the literature towards notable recent studies. In ten sections, we briefly highlight early milestones within this field and its first clinical success stories. We showcase current clinical trials, which focus on gene replacement, gene augmentation, or gene suppression strategies. Next, we discuss ongoing efforts to improve the tropism of rAAV vectors for brain applications and introduce pre-clinical research directed toward harnessing rAAV vectors for gene editing applications. Subsequently, we present common genetic elements coded by the single-stranded DNA of rAAV vectors, their so-called payloads. Our focus is on recent advances that are bound to increase treatment efficacies. As needed, we included studies outside the neurodegenerative disease field that showcased improved pre-clinical designs of all-in-one rAAV vectors for gene editing applications. Finally, we discuss risks associated with off-target effects and inadvertent immunogenicity that these technologies harbor as well as the mitigation strategies available to date to make their application safer.
Beneficial Effects of Resveratrol and γ-Cyclodextrin on the Hematological and Biochemical Parameters of Healthy Wistar Rats Treated with Cisplatin: A PCA Approach
Authors: Hădărugă Nicoleta-Gabriela , Gârban Zeno , Baltă Cornel , Muselin Florin , Hădărugă Daniel-Ioan , Riviş Mircea
Published: October 2023

It is well known that platinum-based antineoplastic agents, including cisplatin (CP), have side effects that limit their use. Nefrotoxicity, neurotoxicity, and hemolytic anemia are the most common side effects. There are few studies on the reduction in these effects that involves nanoencapsulation; however, almost none involve cyclodextrins (CDs). Changes in the hematological and biochemical parameters of healthy Wistar rats treated with solutions of γ-cyclodextrin/resveratrol/cisplatin (γ-CD/Rv/CP) ternary complexes are investigated for the first time. They are intraperitoneally injected with γ-CD/Rv/CP solutions containing 5 mg CP/kg.b.w. Single shots were administered to six groups of Wistar rats (six individuals for every group) using γ-CD/Rv/CP, γ-CD/CP, γ-CD/Rv complexes, as well as positive- and negative-control groups, respectively. Thirty-two hematological and biochemical parameters were evaluated from blood samples and used as input variables for the principal component analysis (PCA) discrimination of the groups. The best protection was obtained for the γ-CD/Rv/CP ternary complex, which determined closer biochemical values to the control group. These values significantly differ from those of the γ-CD/CP treated group, especially for the IP, UA, and T-Pro kidney-related biochemical parameters. This finding proves the beneficial influence of Rv during CP administration through CD-based carriers.
Neurologic Injury-Related Predisposing Factors of Post-Traumatic Stress Disorder: A Critical Examination
Authors: Gillam Wiley , Godbole Nikhil , Sangam Shourya , DeTommaso Alyssa , Foreman Marco , Lucke-Wold Brandon
Published: October 2023

The present review aimed to identify the means through which neurologic injury can predispose individuals to Post-Traumatic Stress Disorder (PTSD). In recent years, comprehensive studies have helped to clarify which structures in the central nervous system can lead to distinct PTSD symptoms—namely, dissociative reactions or flashbacks—when damaged. Our review narrowed its focus to three common neurologic injuries, traumatic brain injury (TBI), subarachnoid hemorrhage (SAH), and stroke. We found that in each of the three cases, individuals may be at an increased risk of developing PTSD symptoms. Beyond discussing the potential mechanisms by which neurotrauma may lead to PTSD, we summarized our current understanding of the pathophysiology of the disorder and discussed predicted associations between the limbic system and PTSD. In particular, the effect of noradrenergic neuromodulatory signaling on the hypothalamic pituitary adrenal (HPA) axis as it pertains to fear memory recall needs to be further explored to better understand its effects on limbic structures in PTSD patients. At present, altered limbic activity can be found in both neurotrauma and PTSD patients, suggesting a potential causative link. Particularly, changes in the function of the limbic system may be associated with characteristic symptoms of PTSD such as intrusive memories and acute psychological distress. Despite evidence demonstrating the correlation between neurotrauma and PTSD, a lack of PTSD prognosis exists in TBI, SAH, and stroke patients who could benefit from early treatment. It should be noted that PTSD symptoms often compound with pre-existing issues, further deteriorating health outcomes for these patients. It is ultimately our goal to clarify the relationship between neurotrauma and PTSD so that earlier diagnoses and appropriate treatment are observed in clinic.
YOLOv5-MS: Real-Time Multi-Surveillance Pedestrian Target Detection Model for Smart Cities
Authors: Song Fangzheng , Li Peng
Published: October 2023

Intelligent video surveillance plays a pivotal role in enhancing the infrastructure of smart urban environments. The seamless integration of multi-angled cameras, functioning as perceptive sensors, significantly enhances pedestrian detection and augments security measures in smart cities. Nevertheless, current pedestrian-focused target detection encounters challenges such as slow detection speeds and increased costs. To address these challenges, we introduce the YOLOv5-MS model, an YOLOv5-based solution for target detection. Initially, we optimize the multi-threaded acquisition of video streams within YOLOv5 to ensure image stability and real-time performance. Subsequently, leveraging reparameterization, we replace the original BackBone convolution with RepvggBlock, streamlining the model by reducing convolutional layer channels, thereby enhancing the inference speed. Additionally, the incorporation of a bioinspired “squeeze and excitation” module in the convolutional neural network significantly enhances the detection accuracy. This module improves target focusing and diminishes the influence of irrelevant elements. Furthermore, the integration of the K-means algorithm and bioinspired Retinex image augmentation during training effectively enhances the model’s detection efficacy. Finally, loss computation adopts the Focal-EIOU approach. The empirical findings from our internally developed smart city dataset unveil YOLOv5-MS’s impressive 96.5% mAP value, indicating a significant 2.0% advancement over YOLOv5s. Moreover, the average inference speed demonstrates a notable 21.3% increase. These data decisively substantiate the model’s superiority, showcasing its capacity to effectively perform pedestrian detection within an Intranet of over 50 video surveillance cameras, in harmony with our stringent requisites.
Human TIMP1 Is a Growth Factor That Improves Oocyte Developmental Competence
Authors: Manríquez-Treviño Yolanda , Sánchez-Ramírez Blanca , Grado-Ahuir Juan Alberto , Castro-Valenzuela Beatriz , González-Horta Carmen , Burrola-Barraza M.Eduviges
Published: October 2023

Oocyte developmental competence is the ability of a mature oocyte to be fertilized and subsequently support embryonic development. Such competence is gained during folliculogenesis and is facilitated by the bidirectional communication into a compacted cumulus–oocyte complex (COC). Human tissue inhibitor of metalloproteinases-1 (TIMP1) participates in biological processes, including cell growth, differentiation, and apoptosis. This study aimed to evaluate the influence of TIMP1 as a growth factor on the in vitro maturation (IVM) culture of bovine COCs to improve oocyte developmental competence. All TIMP1 treatments (50, 100, and 150 ng/mL) favored the COCs’ compaction structure (p < 0.05). TIMP1 at 150 ng/mL produced more oocytes in metaphase II compared to the other treatments (p < 0.05). The 150 ng/mL TIMP1 generated oocytes with the most (p < 0.05) cortical granules below the plasma membrane (pattern I). In a parthenogenesis assay, oocyte IVM in 50 ng/mL of TIMP1 produced the most blastocyst compared to the other treatments (p < 0.05). The Principal Component Analysis (PCA) showed that 50 ng/mL of TIMP1 was the best condition to develop oocyte competence because it was associated with the COC compact and cortical granule pattern I. TIMP1 influences the development of oocyte competence when added to the IVM culture medium of COCs.
Investigating the Potential of Greener-Porous Graphene for the Treatment of Organic Pollutants in Wastewater
Authors: Joshi Bhavya , Khalil Ahmed M. E. , Zhang Shaowei , Memon Fayyaz A.
Published: October 2023

Pharmaceuticals have emerged as a new class of ecological pollutants and have majorly contributed to harmful effects on the environment and human health. The presence of these pharmaceuticals in wastewater treatment plants, ground, and seawater has been reported widely. Organic dyes and other organic contaminants which are being considered as emerging contaminants are now in the race among the top organic pollutants that need effective treatment. Removal of these contaminants via green adsorbents has become an essential requirement towards a green and cleaner environment. Herein, we report the efficacy of the novel greener porous graphene obtained via the near-green synthesis method as an adsorbent material for treating seven organic pollutants: Methyl orange, Methyl red, Rhodamine-B, Ciprofloxacin, Atenolol, Ibuprofen, and Carbamazepine. Batch tests were conducted to investigate the effect of adsorption time and varying adsorbent dosages. The obtained greener porous graphene showed fast kinetics, which was determined to be guided by pseudo second-order kinetics and the maximum pollutant removal efficiency (>80%) was seen at a high adsorbent dosage (2 mL injected from a 5 g/L solution). Furthermore, the nonlinear adsorption modeling confirmed that the greener porous graphene followed the Langmuir model for the dye rhodamine-B sorption and the Freundlich model for all the other six contaminants. This greener porous graphene can be considered an effective adsorbent for the removal of organic pollutants in wastewater.
Unveiling Insights into Ovarian Cancer Metabolism through Space- and Time-Resolved Analysis
Authors: Jia Wei , Li Mengci
Published: October 2023

High-grade serous carcinoma (HGSC) represents a formidable challenge in the realm of ovarian cancer, notorious for its elusive early detection, poor prognosis and limited understanding of the intricacies of its pathogenesis [...]
Exosomal microRNA/miRNA Dysregulation in Respiratory Diseases: From Mycoplasma-Induced Respiratory Disease to COVID-19 and Beyond
Authors: Wang Yingjie , Zou Mengyun , Zhao Yabo , Kabir Md. Ahsanul , Peng Xiuli
Published: October 2023

Respiratory diseases represent a significant economic and health burden worldwide, affecting millions of individuals each year in both human and animal populations. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are involved in various physiological and pathological processes. Exosomal miRNAs and cellular miRNAs have been identified as key regulators of several immune respiratory diseases, such as chronic respiratory diseases (CRD) caused by Mycoplasma gallisepticum (MG), Mycoplasma pneumoniae pneumonia (MMP) caused by the bacterium Mycoplasma pneumoniae, coronavirus disease 2019 (COVID-19), chronic obstructive pulmonary disease (COPD), asthma, and acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Consequently, miRNAs seem to have the potential to serve as diagnostic biomarkers and therapeutic targets in respiratory diseases. In this review, we summarize the current understanding of the functional roles of miRNAs in the above several respiratory diseases and discuss the potential use of miRNAs as stable diagnostic biomarkers and therapeutic targets for several immune respiratory diseases, focusing on the identification of differentially expressed miRNAs and their targeting of various signaling pathways implicated in disease pathogenesis. Despite the progress made, unanswered questions and future research directions are discussed to facilitate personalized and targeted therapies for patients with these debilitating conditions.
Natural Gas Liquids into Motor Gasolines: Methodology for Processing on a Zeolite Catalyst and Development of Blending Recipes
Authors: Altynov Andrey , Bogdanov Ilya , Lukyanov Daniil , Kirgina Maria
Published: October 2023

Natural gas liquids are a by-product of natural gas preparation, one of the most common and environmentally friendly energy sources. In natural gas fields located in remote areas, there is no resource-efficient way to use natural gas liquids. However, natural gas liquids are a valuable hydrocarbon feedstock for the production of motor fuels, in particular motor gasolines. The aim of this work is to develop a method for obtaining motor gasolines by processing natural gas liquids on a zeolite catalyst, taking into account the influence of the particle size of the zeolite catalyst, the technological parameters of the process, and the composition of the feedstock. As part of the work, for the first time, regularities of the influence of zeolite catalyst particle size, technological parameters of the process and the composition of feedstock on the composition and characteristics of the resulting processed products were revealed. A database about the composition and characteristics of natural gas liquids, obtained from various gas fields in Western Siberia of the Russian Federation, has been accumulated. During the study, it was found that the optimal particle size of the zeolite catalyst is 0.50–1.00 mm; optimal technological parameters are a temperature of 375 °C, pressure 2.5 atm. and the feedstock space velocity 2 h−1. It is shown that the processing of natural gas liquids of various compositions on a zeolite catalyst, on average, makes it possible to increase their detonation resistance by more than 16 points. The results obtained indicate the prospects of using the process for the production of motor gasoline. The paper presents a number of blending recipes for obtaining fuels, both within the framework of production at the fields and at processing plants.
Chemical Composition of Different Extracts from Echinacea purpurea (L.) Moench Roots and Evaluation of Their Antimicrobial Activity
Authors: Petkova Nadezhda , Petrova Ani , Ivanov Ivan , Hambarlyiska Ivanka , Tumbarski Yulian , Dincheva Ivayla , Ognyanov Manol , Denev Petko
Published: October 2023

This research aimed to reveal the chemical composition of different fractions obtained by sequential extraction of purple coneflower (Echinacea purpurea) roots and to evaluate the antimicrobial activity of some of them. Hexane, chloroform, ethyl acetate, and water were used as solvents to obtain the corresponding extracts. A GC-MS analysis was employed to reveal the chemical composition of hexane, chloroform, and ethyl acetate fractions. Conventional and ultrasound-assisted water extraction was performed to isolate inulin-type polysaccharides. Eighteen microorganisms were used for testing the antimicrobial activity of the obtained organic extracts. From GC-MS analysis more than forty compounds were detected in the fractions, including fatty acids, organic acids, fatty alcohols, sterols, and terpenes. Only in ethyl acetate extract were found mannitol and fructose isomers, while in chloroform extract were detected α- and β-amyrin, and betulin. Ethyl acetate fraction demonstrated the highest antimicrobial activity against 11 microorganisms (Bacillus cereus, B. amyloliquefaciens, Staphylococcus aureus, Listeria monocytogenes, Salmonella enteritis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans, Saccharomices cerevisiae, and Peniclium sp.). The polysaccharide fractions were structurally characterized by FT-IR and NMR studies as linear inulin having β-(2→1)-linked Fru units and a T-Glc unit linked α-(1→2). Inulin from coneflower roots showed poor flowability, promising bulk and tapped density, swelling properties, and better oil-holding than water-holding capacity. This study demonstrated the potential of coneflower root fractions as a rich source of phytochemicals with antimicrobial activities and potential prebiotic activity due to inulin content (15% yield) and echinacea root as a useful biobased industrial crop/material.
Photonics and Plasmonics: New Challenges for Optical Nanostructured Materials in Sensing
Authors: Paladini Alessandra , Prosposito Paolo , Venditti Iole
Published: October 2023

In the last decade, new technologies have undertaken an extraordinary development, based not only on new materials and new processes but also on design, modelling, information technology, and artificial intelligence [...]
Disease Diagnosis with Chemosensing, Artificial Intelligence, and Prospective Contributions of Nanoarchitectonics
Authors: Shen Xuechen , Ariga Katsuhiko
Published: October 2023

In modern materials research, nanotechnology will play a game-changing role, with nanoarchitectonics as an overarching integrator of the field and artificial intelligence hastening its progress as a super-accelerator. We would like to discuss how this schema can be utilized in the context of specific applications, with exemplification using disease diagnosis. In this paper, we focus on early, noninvasive disease diagnosis as a target application. In particular, recent trends in chemosensing in the detection of cancer and Parkinson’s disease are reviewed. The concept has been gaining traction as dynamic volatile metabolite profiles have been increasingly associated with disease onset, making them promising diagnostic tools in early stages of disease. We also discuss advances in nanoarchitectonic chemosensors, which are theoretically ideal form factors for diagnostic chemosensing devices. Last but not least, we shine the spotlight on the rise to prominence and emergent contributions of artificial intelligence (AI) in recent works, which have elucidated a strong synergy between chemosensing and AI. The powerful combination of nanoarchitectonic chemosensors and AI could challenge our current notions of disease diagnosis. Disease diagnosis and detection of emerging viruses are important challenges facing society. The parallel development of advanced functional materials for sensing is necessary to support and enable AI methodologies in making technological leaps in applications. The material and structural formative technologies of nanoarchitectonics are critical in meeting these challenges.
Anthropometric Characteristics and Weight Status of Early Adolescents (Aged 12–14) in Montenegro; Urban–Rural and Regional Differences
Authors: Katanic Borko , Bjelica Dusko , Stankovic Mima , Milosevic Zoran , Vukovic Jovan , Mekic Amel
Published: October 2023

The aim of this study was to determine urban–rural and regional differences in anthropometric characteristics among adolescents aged 12–14, as well as to present the prevalence of weight status. A total of 534 adolescents aged 12–14 from primary schools across Montenegro participated in this cross-sectional study (283 boys, aged 13.52 ± 0.42, body height 169.43 ± 8.89, body weight 60.54 ± 13.47; 251 girls, aged 13.51 ± 0.40, body height 165.54 ± 6.67, body weight 55.28 ± 9.27). The sample was divided by geographic region in Montenegro into northern, central, and coastal regions, and according to settlement type into urban and rural inhabitants. Anthropometric characteristics were assessed using a battery of seven variables: arm span (AS); body height (BH); body weight (BW); waist circumference (WC); hip circumference (HC); body mass index (BMI); and waist-to-hip ratio (WHR). BMI was categorized based on the World Health Organization’s (WHO) cut-offs. The results indicate that girls from urban areas exhibited significantly greater body height and lower BMI values compared to their rural counterparts. Similarly, boys from urban areas also demonstrated lower BMI values compared to their rural peers. However, no statistically significant differences were observed in other anthropometric characteristics between these two groups of adolescents. Based on analysis of variance (ANOVA) and post-hoc analysis, it was found that girls from central areas had significantly greater body height compared to those from northern and coastal areas. Likewise, boys from northern areas showed higher body mass and BMI values compared to those from central areas. Additionally, both boys and girls from central areas had higher values compared to those from coastal areas. Nevertheless, no significant differences were detected in other anthropometric characteristics among adolescents from these regions. This study identified significant differences in anthropometric parameters among participants based on urban–rural status and within regional divisions. However, further research encompassing a larger sub-sample and a broader array of anthropometric variables is needed to draw a more comprehensive conclusion.