bluuebunny/crossref_metadata_2025 huggingface dataset:
Holding Time Influence on the Hot Ductility Behavior of a Continuously Cast Low Alloy Steel
Authors: Gontijo Marina , Hoflehner Christian , Ilie Sergiu , Six Jakob , Sommitsch Christof
Published: December 2020

Cracking during the continuous casting process is undesirable and continuous work is being carried out to find further improvements and understand the mechanisms that lead to failure. Investigations on the hot ductility behavior of a continuously cast low alloyed steel using different holding times before straining were done in the present work. Samples were heated to melting temperature in a vacuum atmosphere and then cooled to one of the three test temperatures chosen: 750, 850, and 900 °C. When the desired temperature was reached, the sample was isothermally held for either 10, 90, 300, or 3600 s before the tensile test started, with a strain rate of 10−3 s−1. The reduction of area was measured, SEM images of the fractured surfaces were taken plus LOM images for the analysis of the microstructure. The results show that there was no significant change in the ductility at any of the temperatures until 300 s, with a change in behavior at 3600 s. This was further confirmed with the images and precipitation kinetics simulations. The results are described and compared.
Decrease in Myelin-Associated Lipids Precedes Neuronal Loss and Glial Activation in the CNS of the Sandhoff Mouse as Determined by Metabolomics
Authors: Lecommandeur Emmanuelle , Cachón-González Maria Begoña , Boddie Susannah , McNally Ben D. , Nicholls Andrew W. , Cox Timothy M. , Griffin Julian L.
Published: December 2020

Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the β subunit of β-hexosaminidase, leading to deficiency in the enzymes β-hexosaminidase (HEX) A and B. SD is characterised by an accumulation of gangliosides and related glycolipids, mainly in the central nervous system, and progressive neurodegeneration. The underlying cellular mechanisms leading to neurodegeneration and the contribution of inflammation in SD remain undefined. The aim of the present study was to measure global changes in metabolism over time that might reveal novel molecular pathways of disease. We used liquid chromatography-mass spectrometry and 1H Nuclear Magnetic Resonance spectroscopy to profile intact lipids and aqueous metabolites, respectively. We examined spinal cord and cerebrum from healthy and Hexb−/− mice, a mouse model of SD, at ages one, two, three and four months. We report decreased concentrations in lipids typical of the myelin sheath, galactosylceramides and plasmalogen-phosphatidylethanolamines, suggesting that reduced synthesis of myelin lipids is an early event in the development of disease pathology. Reduction in neuronal density is progressive, as demonstrated by decreased concentrations of N-acetylaspartate and amino acid neurotransmitters. Finally, microglial activation, indicated by increased amounts of myo-inositol correlates closely with the late symptomatic phases of the disease.
Surfactant-Laden Janus Droplets with Tunable Morphologies and Enhanced Stability for Fabricating Lens-Shaped Polymeric Microparticles
Authors: Xu Siyuan , Nisisako Takasi
Published: December 2020

Janus droplets can function as excellent templates for fabricating physically and chemically anisotropic particles. Here, we report new surfactant-laden Janus droplets with curvature controllability and enhanced stability against coalescence, suitable for fabricating shape-anisotropic polymer microparticles. Using a microfluidic flow-focusing device on a glass chip, nanoliter-sized biphasic droplets, comprising an acrylate monomer segment and a silicone-oil (SO) segment containing a surfactant, were produced in a co-flowing aqueous polyvinyl alcohol (PVA) solution. At equilibrium, the droplets formed a Janus geometry based on the minimization of interfacial energy, and each of the two Janus segments were uniform in size with coefficient-of-variation values below 3%. By varying the concentration of the surfactant in the SO phase, the curvature of the interface between the two lobes could be shifted among concave, planar, and convex shapes. In addition, the Janus droplets exhibited significantly improved stability against coalescence compared with previously reported Janus droplets carrying no surfactant that coalesced rapidly. Finally, via off-chip photopolymerization, concave-convex, planar-convex, and biconvex lens-shaped particles were fabricated.
Desymmetrizing Heteroleptic [Cu(P^P)(N^N)][PF6] Compounds: Effects on Structural and Photophysical Properties, and Solution Dynamic Behavior
Authors: Meyer Marco , Brunner Fabian , Prescimone Alessandro , Constable Edwin C. , Housecroft Catherine E.
Published: December 2020

The preparation, characterization and electrochemical and photophysical properties of a series of desymmetrized heteroleptic [Cu(P^P)(N^N)][PF6] compounds are reported. The complexes incorporate the chelating P^P ligands bis(2-(diphenylphosphanyl)phenyl)ether (POP) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphane) (xantphos), and 6-substituted 2,2′-bipyridine (bpy) derivatives with functional groups attached by –(CH2)n– spacers: 6-(2,2′-bipyridin-6-yl)hexanoic acid (1), 6-(5-phenylpentyl)-2,2′-bipyridine (2) and 6-[2-(4-phenyl-1H-1,2,3,triazol-1-yl)ethyl]-2,2′-bipyridine (3). [Cu(POP)(1)][PF6], [Cu(xantphos)(1)][PF6], [Cu(POP)(2)][PF6], [Cu(xantphos)(2)][PF6], and [Cu(xantphos)(3)][PF6] have been characterized in solution using multinuclear NMR spectroscopy, and the single crystal structure of [Cu(xantphos)(3)][PF6].0.5Et2O was determined. The conformation of the 6-[2-(4-phenyl-1H-1,2,3,triazol-1-yl)ethyl]-substituent in the [Cu(xantphos)(3)]+ cation is such that the α- and β-CH2 units reside in the xanthene ‘bowl’ of the xantphos ligand. The 6-substituent desymmetrizes the structure of the [Cu(P^P)(N^N)]+ cation and this has consequences for the interpretation of the solution NMR spectra of the five complexes. The NOESY spectra and EXSY cross-peaks provide insight into the dynamic processes operating in the different compounds. For powdered samples, emission maxima are in the range 542–555 nm and photoluminescence quantum yields (PLQYs) lie in the range 13–28%, and a comparison of PLQYs and decay lifetimes with those of [Cu(xantphos)(6-Mebpy)][PF6] indicate that the introduction of the 6-substituent is not detrimental in terms of the photophysical properties.
Peptide-Based Nanomaterials for Tumor Immunotherapy
Authors: Li Lingyun , Ma Bing , Wang Weizhi
Published: December 2020

With the increasing understanding of tumor immune circulation mechanisms, tumor immunotherapy including immune checkpoint blockade has become a research hotspot, which requires the development of more accurate and more efficient drugs with fewer side effects. In line with this requirement, peptides with good biocompatibility, targeting, and specificity become favorable theranostic reagents, and a series of promising candidates for tumor immunotherapy based on peptides have been developed. Additionally, the advantages of nanomaterials as drug carriers such as higher affinity have been demonstrated, providing possibilities of combination therapy. In this review, we summarize the development of peptide-based nanomaterials in tumor immunotherapy from the two aspects of functionalization and self-assembly. Furthermore, new methods for peptide screening, especially machine-learning-related strategies, is also a topic we were interested in, as this forms the basis for the construction of peptide-based platforms. Peptides provide broad prospects for tumor immunotherapy and we hope that this summary can provide insight into possible avenues for future exploration.
An Efficient Workflow for Screening and Stabilizing CRISPR/Cas9-Mediated Mutant Lines in Bombyx mori
Authors: Brady Daniel , Saviane Alessio , Cappellozza Silvia , Sandrelli Federica
Published: December 2020

The domestic silkworm Bombyx mori is extensively studied as a model organism for lepidopteran genetics and has an economic value in silk production. Silkworms also have applications in biomedical and cosmetic industries, and the production of mutant B. mori strains significantly enhances basic and applied silkworm research. In recent years, CRISPR/Cas9 technology is being rapidly adopted as the most efficient molecular tool for generating silkworm lines carrying mutations in target genes. Here we illustrate a complete and efficient workflow to screen, characterize rapidly and follow mutations through generations, allowing the generation of B. mori lines, stably inheriting single CRISPR/Cas9-induced mutations. This approach relies on the use of different molecular methods, the heteroduplex assay, cloning followed by Sanger sequencing, and the amplification refractory mutation system PCR. The use of these methodologies in a sequential combination allows the identification of CRISPR/Cas9-induced mutations in genes mapping on both autosomes and sex chromosomes, and the selection of appropriate individuals to found stable mutant B. mori lines. This protocol could be further applied to screen CRISPR/Cas9 mutations in haploid insects.
Electrochemical Oxidation of Ti15Mo Alloy—The Impact of Anodization Parameters on Surface Morphology of Nanostructured Oxide Layers
Authors: Jarosz Magdalena , Zaraska Leszek , Kozieł Marcin , Simka Wojciech , Sulka Grzegorz D.
Published: December 2020

It is well-known that the structure and composition of the material plays an important role in the processes occurring at the surface. In this paper, a surface morphology of nanostructured oxide layers electrochemically grown on Ti15Mo, tuned by applying different anodization parameters, was investigated in detail. The one-step anodization of Ti15Mo alloy was performed at room temperature in an ethylene glycol-based electrolyte containing 0.11 M NH4F and 1.11 M H2O. Different anodization times (ranging from 5 to 60 min) and applied potentials (40–100 V) were tested, and the surface morphology, elemental content, and crystalline structure were monitored by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), and X-ray diffractometry (XRD), respectively. The results showed that contrary to the multistep anodization of titanium foil, the surface morphology of anodic oxide obtained via the one-step process contains the nanoporous outer layer covering the nanotubular structure. What is more, the pore diameter (Dp) and interpore distance (Dint) of such layers exhibit different trends than those observed for anodization of pure titanium. In particular, at a certain potential range, a decrease in both Dp and Dint with increasing potential was observed. However, independently on the used anodization conditions, the elemental content of oxide layers remained similar, showing the amount of molybdenum at c.a. 15 wt.%. Finally, the amorphous nature of as-anodized layers was confirmed, and their optical band-gap was determined from the diffuse reflectance UV–Vis spectra. It was found that Eg is tunable to some extent by changing the anodizing potential. However, further thermal treatment in air at 400 °C resulted in the anatase phase formation that was accompanied by a significant Eg reduction. Therefore, we believe that the presented results will greatly contribute to the understanding of anodic formation of nanostructured functional oxide layers with tunable properties that can be applied in various fields.
Biodistribution and Radiation Dosimetric Analysis of [68Ga]Ga-RM2: A Potent GRPR Antagonist in Prostate Carcinoma Patients
Authors: Haendeler Matthias , Khawar Ambreen , Ahmadzadehfar Hojjat , Kürpig Stefan , Meisenheimer Michael , Essler Markus , Gaertner Florian C. , Bundschuh Ralph A.
Published: December 2020

[68Ga]Ga-RM2 is a promising innovative positron emission tomography (PET) tracer for patients with primary or metastatic prostate carcinoma. This study aims to analyze the biodistribution and radiation dosimetry of [68Ga]Ga-RM2 in five prostate cancer patients. The percentages of injected activity in the source organs and blood samples were determined. Bone marrow residence time was calculated using an indirect blood-based method. OLINDA/EXM version 2.0 (Hermes Medical Solutions, Stockholm, Sweden) was used to determine residence times, organ absorbed and effective doses. Physiological uptake was seen in kidneys, urinary bladder, pancreas, stomach, spleen and liver. Blood clearance was fast and followed by rapid clearance of activity from kidneys resulting in high activity concentrations in the urinary bladder. The urinary bladder wall was the most irradiated organ with highest mean organ absorbed dose (0.470 mSv/MBq) followed by pancreas (0.124 mSv/MBq), stomach wall (0.063 mSv/MBq), kidneys (0.049 mSv/MBq) and red marrow (0.010 mSv/MBq). The effective dose was found to be 0.038 mSv/MBq. Organ absorbed doses were found to be comparable to other gallium-68 labelled GRPR antagonists and lower than [68Ga]Ga-PSMA with the exception of the urinary bladder, pancreas and stomach wall. Remarkable interindividual differences were observed for the organ absorbed doses. Therefore, [68Ga]Ga-RM2 is a safe diagnostic agent with a significantly lower kidney dose but higher pancreas and urinary bladder doses as compared to [68Ga]Ga-PSMA.
Enhancing Pension Adequacy While Reducing the Fiscal Budget and Creating Essential Capital for Domestic Investments and Growth: Analysing the Risks and Outcomes in the Case of Greece
Authors: Symeonidis Georgios , Tinios Platon , Xenos Panos
Published: December 2020

Many countries around the world are resorting to mandatory funded components in their multi-pillar pension systems with the purpose of catering for the financial pressure from ageing. This paper aims at analysing the possible replacement rates for such a scheme, by choosing different assumptions and setting the best combined area for the expected result. Then, an approach for analysing the potential for the implementation of such a scheme in Greece is presented along with the actuarially projected expected benefit expenditure and respective accrued capital. A result of the introduction of such a component is expected to be the elevated replacement rate at retirement with a concurrent alleviation of the fiscal burden for the state. The projected scale of savings will also provide domestic financing for investments generating growth.
A Laterally Vibrating Lithium Niobate MEMS Resonator Array Operating at 500 °C in Air
Authors: Eisner Savannah R. , Chapin Cailin A. , Lu Ruochen , Yang Yansong , Gong Songbin , Senesky Debbie G.
Published: December 2020

This paper reports the high-temperature characteristics of a laterally vibrating piezoelectric lithium niobate (LiNbO3; LN) MEMS resonator array up to 500 °C in air. After a high-temperature burn-in treatment, device quality factor (Q) was enhanced to 508 and the resonance shifted to a lower frequency and remained stable up to 500 °C. During subsequent in situ high-temperature testing, the resonant frequencies of two coupled shear horizontal (SH0) modes in the array were 87.36 MHz and 87.21 MHz at 25 °C and 84.56 MHz and 84.39 MHz at 500 °C, correspondingly, representing a −3% shift in frequency over the temperature range. Upon cooling to room temperature, the resonant frequency returned to 87.36 MHz, demonstrating the recoverability of device performance. The first- and second-order temperature coefficient of frequency (TCF) were found to be −95.27 ppm/°C and 57.5 ppb/°C2 for resonant mode A, and −95.43 ppm/°C and 55.8 ppb/°C2 for resonant mode B, respectively. The temperature-dependent quality factor and electromechanical coupling coefficient (kt2) were extracted and are reported. Device Q decreased to 334 and total kt2 increased to 12.40% after high-temperature exposure. This work supports the use of piezoelectric LN as a material platform for harsh environment radio-frequency (RF) resonant sensors (e.g., temperature and infrared) incorporated with high coupling acoustic readout.
Joint Spreading Factor and Channel Assignment in Multi-Operator LoRaWAN Deployments
Authors: Fawaz Hassan , Khawam Kinda , Lahoud Samer , Adjih Cedric , Martin Steven
Published: December 2020

LoRaWAN is a popular internet of things (IoT) solution over the unlicensed radio band. It sustains low-cost, durable, and long range IoT wireless communications. Nonetheless, with over 24 billion connected IoT devices being expected by the end of the year, and over 50 billion by 2025, the concurrent and legacy approaches to spreading factor and channel assignment in LoRaWAN networks can no longer keep up. This is exacerbated with the growing densification of IoT device deployments and, with the increasing requirements for better throughput and packet delivery ratios. In this paper, we propose a proportional fair-based joint optimal formulation for spreading factor and channel assignment in multi-operator LoRaWAN deployments. The objective of this problem is to maximize the total sum of the logarithmic normalized throughput. We split the problem into two subproblems, and propose a game theoretic approach to solving them. We prove that our games converge towards a pure Nash equilibrium and, afterwards, solve the optimization problems using both semi-distributed and completely distributed algorithms. Via simulations, we show that our algorithms greatly improve the total normalized throughput for LoRaWAN as well as the packet success rate, in comparison to the legacy approaches.
Monitoring Strain Response of Epoxy Resin during Curing and Cooling Using an Embedded Strain Gauge
Authors: Dong Hongyu , Liu Huiming , Nishimura Arata , Wu Zhixiong , Zhang Hengcheng , Han Yemao , Wang Tao , Wang Yongguang , Huang Chuanjun , Li Laifeng
Published: December 2020

The present work describes the monitoring system of the real-time strain response on the curing process of epoxy resin from the initial point of curing to the end, and the change in strain during temperature changes. A simple mould was designed to embed the strain gauge, thermometer, and quartz standard sample into the epoxy resin, so that the strain and the temperature were simultaneously measured and recorded. A cryogenic-grade epoxy resin was tested and the Differential Scanning Calorimetry (DSC) was used to analyse the curing process. Based on the DSC results, three curing processes were adopted to investigate their influence on strain response as well as residual strain of the epoxy resin. Moreover, impact strength of the epoxy resin with various curing temperatures were tested and the results indicate that the curing plays a crucial role on the mechanical properties. The method will find cryogenic application of epoxy adhesives and epoxy resin based composites to monitor the strain during the curing process as well as the cryogenic service.
Real-Time Monitoring of Yogurt Fermentation Process by Aquaphotomics Near-Infrared Spectroscopy
Authors: Muncan Jelena , Tei Kyoko , Tsenkova Roumiana
Published: December 2020

Automated quality control could have a substantial economic impact on the dairy industry. At present, monitoring of yogurt production is performed by sampling for microbiological and physicochemical measurements. In this study, Near-Infrared Spectroscopy (NIRS) is proposed for non-invasive automated control of yogurt production and better understanding of lactic acid bacteria (LAB) fermentation. UHT (ultra-high temperature) sterilized milk was inoculated with Bulgarian yogurt and placed into a quartz cuvette (1 mm pathlength) and test-tubes. Yogurt absorbance spectra (830–2500 nm) were acquired every 15 min, and pH, in the respective test-tubes, was measured every 30 min, during 8 h of fermentation. Spectral data showed substantial baseline and slope changes with acidification. These variations corresponded to respective features of the microbiological growth curve showing water structural changes, protein denaturation, and coagulation of milk. Moving Window Principal Component Analysis (MWPCA) was applied in the spectral range of 954–1880 nm to detect absorbance bands where most variations in the loading curves were caused by LAB fermentation. Characteristic wavelength regions related to the observed physical and multiple chemical changes were identified. The results proved that NIRS is a valuable tool for real-time monitoring and better understanding of the yogurt fermentation process.
Estimation of the Filling Distribution and Height Levels Inside an Insulated Pressure Vessel by Guided Elastic Wave Attenuation Tomography
Authors: Neubeck Robert , Stephan Mareike , Gaul Tobias , Weihnacht Bianca , Schubert Lars , Bindingsbø Arne Ulrik , Østvik Jan-Magnus
Published: December 2020

The operation efficiency and safety of pressure vessels in the oil and gas industry profits from an accurate knowledge about the inner filling distribution. However, an accurate and reliable estimation of the multi-phase height levels in such objects is a challenging task, especially when considering the high demands in practicability, robustness in harsh environments and safety regulations. Most common systems rely on impractical instrumentation, lack the ability to measure solid phases or require additional safety precautions due to their working principle. In this work, another possibility to determine height levels by attenuation tomography with guided elastic waves is proposed. The method uses a complete instrumentation on the outer vessel shell and is based on the energy conversion rates along the travel path of the guided waves. Noisy data and multiple measurements from sparsely distributed sensor networks are translated into filling levels with accuracies in the centimeter range by solving a constrained optimization problem. It was possible to simultaneously determine sand, water, and oil phases on a mock-up scale experiment, even for artificially created sand slopes. The accuracy was validated by artificial benchmarking for a horizontal vessel, giving references for constructing an affordable prototype system.
Maximum Target Coverage Problem in Mobile Wireless Sensor Networks
Authors: Liang Dieyan , Shen Hong , Chen Lin
Published: December 2020

We formulate and analyze a generic coverage optimization problem arising in wireless sensor networks with sensors of limited mobility. Given a set of targets to be covered and a set of mobile sensors, we seek a sensor dispatch algorithm maximizing the covered targets under the constraint that the maximal moving distance for each sensor is upper-bounded by a given threshold. We prove that the problem is NP-hard. Given its hardness, we devise four algorithms to solve it heuristically or approximately. Among the approximate algorithms, we first develop randomized (1−1/e)-optimal algorithm. We then employ a derandomization technique to devise a deterministic (1−1/e)-approximation algorithm. We also design a deterministic approximation algorithm with nearly ▵−1 approximation ratio by using a colouring technique, where ▵ denotes the maximal number of subsets covering the same target. Experiments are also conducted to validate the effectiveness of the algorithms in a variety of parameter settings.
Development and Reliability Review of an Assessment Tool to Measure Competency in the Seven Elements of the Risk Management Process: Part One—The RISKometric
Authors: Marling Garry , Horberry Tim , Harris Jill
Published: December 2020

Ineffective and inefficient workforce involvement can negatively impact risk management practice for work health and safety (WHS) issues. Often the risk management process is undertaken by a single person, or by teams without a facilitator and without regard to the participants’ levels of competency in the risk management process. This study aimed to develop a tool to assess the competence of individuals in different elements of the risk management process and then review its reliability. This tool, termed the RISKometric, incorporated a 360° performance review method whereby peers upline and downline colleagues and the individual themselves gave competence ratings. The RISKometric was tested using 26 participants. Results showed that a significant positive relationship existed between the feedback given by peers and downline colleagues. Initial results gained from using the tool suggest it is able to discriminate the competence of participants, in each of the elements of risk management, through the opinions of self and others. In future research, we test assumptions through a further two studies. Firstly, that individuals’ RISKometric results are comparable with their performance in a risk scenario exercise; so, providing validity for the tool. Secondly, that a collectively-optimised team (formed using the Riskometric) can perform a risk assessment exercise better than marginally- or sub-optimised teams.
Measurement of Head Circumference: Implications for Microcephaly Surveillance in Zika-Affected Areas
Authors: Harville Emily W. , Tong Van T. , Gilboa Suzanne M. , Moore Cynthia A. , Cafferata Maria Luisa , Alger Jackeline , Gibbons Luz , Bustillo Carolina , Callejas Allison , Castillo Mario , Fúnes Jenny , García Jorge , Hernández Gustavo , López Wendy , Ochoa Carlos , Rico Fátima , Rodríguez Heriberto , Zúniga Concepción , Ciganda Alvaro , Stella Candela , Tomasso Giselle , Buekens Pierre
Published: December 2020

Worldwide recognition of the Zika virus outbreak in the Americas was triggered by an unexplained increase in the frequency of microcephaly. While severe microcephaly is readily identifiable at birth, diagnosing less severe cases requires comparison of head circumference (HC) measurement to a growth chart. We examine measured values of HC and digit preference in those values, and, by extension, the prevalence of microcephaly at birth in two data sources: a research study in Honduras and routine surveillance data in Uruguay. The Zika in Pregnancy in Honduras study enrolled pregnant women prenatally and followed them until delivery. Head circumference was measured with insertion tapes (SECA 212), and instructions including consistent placement of the tape and a request to record HC to the millimeter were posted where newborns were examined. Three indicators of microcephaly were calculated: (1) HC more than 2 standard deviations (SD) below the mean, (2) HC more than 3 SD below the mean (referred to as “severe microcephaly”) and (3) HC less than the 3rd percentile for sex and gestational age, using the INTERGROWTH-21st growth standards. We compared these results from those from a previous analysis of surveillance HC data from the Uruguay Perinatal Information System (Sistema Informático Perinatal (SIP). Valid data on HC were available on 579 infants, 578 with gestational age data. Nine babies (1.56%, 95% CI 0.71–2.93) had HC < 2SD, including two (0.35%, 95% CI 0.04–1.24) with HC < 3SD, and 11 (1.9%, 95% CI, 0.79–3.02) were below the 3rd percentile. The distribution of HC showed strong digit preference: 72% of measures were to the whole centimeter (cm) and 19% to the half-cm. Training and use of insertion tapes had little effect on digit preference, nor were overall HC curves sufficient to detect an increase in microcephaly during the Zika epidemic in Honduras. When microcephaly prevalence needs to be carefully analyzed, such as during the Zika epidemic, researchers may need to interpret HC data with caution.
CHRONIC GASTRITIS AND OLD AGE: A PROBLEM OR NOT?
Authors: Simonova Zh.G. , Prikhod'ko M.N. , Shul'gina E.M.
Published: December 2020

The objective of the paper is to study the clinical and functional characteristics of chronic H. pylori-associated gastritis in the elderly patients.
Materials and Methods. A group of elderly patients (n=116) (aged 69.5±3.2) with chronic H. pylori-associated gastritis was formed during a prospective clinical study. All patients underwent esophagogastroduodenoscopy with biopsy. OLGA staging system was used for histological assessment. The dyspeptic index (DI) was used to measure dyspepsia. The patients were followed up for 48 weeks.
Results. Dyspepsia was found only in 41.3 % of patients, while 58.7 % of patients had asymptomatic disease progression. Atrophic changes in the gastric mucosa were found in 30.1 % of the trial subjects. The efficacy of the eradication therapy was 88.7 %. During the study, the endoscopic picture of the gastroduodenal zone improved. There was no progression of atrophic and metaplastic changes in the gastric mucosa.
Conclusion. Thus, in elderly patients, chronic H. pylori-associated gastritis is often asymptomatic. Eradication of H. pylori infection promotes disease remission and prevents morphological changes in the gastric mucosa.
Keywords: chronic gastritis, Helicobacter pylori, atrophic gastritis, dyspepsia, old age, eradication therapy.
Цель – изучить клинико-функциональные особенности течения хронического H. pylori-ассоциированного гастрита у лиц пожилого возраста.
Материалы и методы. В процессе проспективного клинического исследования была сформирована группа больных (n=116) пожилого возраста (69,5±3,2 года) с хроническим H. pylori-ассоциированным гастритом. Всем больным была выполнена эзофагогастродуоденоскопия с биопсией. Для гистологической оценки применяли классификацию OLGA. Для оценки диспепсического синдрома использовали диспепсический индекс (ДИ). Длительность наблюдения больных составила 48 нед.
Результаты. Наличие диспепсического синдрома было установлено у 41,3 % больных, 58,7 % пациентов имели бессимптомное течение заболевания. У 30,1 % обследуемых выявлены атрофические изменения слизистой оболочки желудка. Эффективность проведенной эрадикационной терапии составила 88,7 %. В процессе исследования установлено улучшение эндоскопической картины гастродуоденальной зоны. Отмечено отсутствие прогрессирования атрофических и метапластических изменений слизистой оболочки желудка.
Выводы. У больных пожилого возраста течение хронического H. pylori-ассоциированного гастрита чаще имеет бессимптомный характер. Эрадикация инфекции H. pylori способствует ремиссии заболевания и предотвращает морфологические преобразования слизистой оболочки желудка.
Ключевые слова: хронический гастрит, Helicobacter pylori, атрофический гастрит, синдром диспепсии, пожилой возраст, эрадикационная терапия.
Muitas mulheres, raras mulheres: representações do feminino nos anúncios dos anos 1920
Authors: Rocha Everardo , Bon Olga
Published: December 2020

Este artigo analisa as representações do feminino em um conjunto de anúncios veiculados na revista Careta na década de 1920. A revista Careta foi um dos mais importantes veículos de comunicação disponíveis ao público de grandes centros urbanos como a cidade do Rio de Janeiro, então capital federal, e circulou de 1908 a 1960. Os anúncios estudados nesse trabalho reúnem um material capaz de refletir certos modelos de enquadramento e representação do feminino naquele período, que destacavam alguns e silenciavam outros tantos modos de existência e tipos de mulher na sociedade urbana brasileira. Enquanto os anúnciosvendiam uma compreensão coletiva de tipos idealizados, havia uma afluência de outras mulheres, com diferentes perfis, desejos, funções, trabalhos e reivindicações, que se amalgamavam naquela sociedade. Eram seletivos e elegiam uma representação dentro do leque de possibilidades experimentadas pelas mulheres em suas relações concretas de vida. Destaca-se o fato de que, nos anúncios, por mais diversos que fossem, os tipos de mulheres escolhidas para serem representadas estavam em congruência com a moda e as novidades da época, exibindo penteados, roupas, maquiagens e acessórios específicos que se revelavam na figura da melindrosa.
Entre a responsabilidade, o conflito e o interesse humano: análise de enquadramento da cobertura sobre biografias
Authors: Ferracioli Paulo , Rizzotto Carla
Published: December 2020

O presente artigo busca compreender quais foram os enquadramentos utilizados pelos veículos jornalísticos brasileiros de alcance nacional em sua cobertura sobre a possibilidade de publicação de biografias não-autorizadas. A análise de enquadramento é uma modalidade de pesquisa que busca descobrir de que maneira os textos jornalísticos salientaram certos aspectos dos acontecimentos em detrimento de outros (ENTMAN, 1993). Após uma revisão das classificações presentes na literatura sobre as pesquisa de enquadramento, são apresentados os enquadramentos genéricos, ou seja, aplicáveis a qualquer cobertura, que conduzirão essa pesquisa: conflito, interesse humano, consequências econômicas, moralidade e responsabilidade (SEMETKO; VALKENBURG, 2000). O corpus a ser analisado consiste nas 56 matérias publicadas pelos três jornais de maior circulação nacional considerados quality papers: Folha de S. Paulo (21 notícias), O Globo (16) e O Estado de S. Paulo (19), ao longo do mês de outubro de 2013. Os dados encontrados demonstram que o conflito foi o enquadramento mais recorrente na cobertura dos veículos,com 20 aparições, seguido pelos frames responsabilidade e interesse humano. Houve poucas ocorrências dos enquadramentos econômico e moralidade. O destaque do frame conflito confirmou uma tendência já apontada pela literatura de que o jornalismo prefere abordar os temas pelo embate entre os personagens envolvidos.
TVs Universitárias mineiras: A atuação dos canais vinculados às IES públicas
Authors: Lopes Ivonete da Silva
Published: December 2020

O “campo público” de comunicação é formado por atores heterogêneos, entre eles, as emissoras universitárias. Este artigo problematiza a noção de campo público, denominação incorporada pela academia do movimento pela democratização da comunicação. O referido campo tem sua diferenciação na especificidade da programação, modelo de gestão, financiamento e propriedade dessas emissoras. A partir da noção de campo social de Bourdieu, questiona-se a existência do campo público de comunicação noBrasil. O trabalho apresenta também o resultado da pesquisa com as TV Universitárias de Minas Gerais. A análise focaliza na atuação de 5 emissoras mantidas por Instituições de Ensino Superior (IES) públicas, sendo uma estadual e quatro federais. A pesquisa de caráter exploratório aponta um cenário bastante crítico para o setor. Das 16 TVs Universitárias (TVUs) mineiras encontradas em mapeamento feito em 2017, 5 delas foram fechadas dois anos depois. Entre as emissoras mantidas por universidades públicas, 3 foram desativadas no mesmo período. Aquelas que continuam em atividade possuem programação local bastante restrita devido à escassez de recursos financeiros. A terceirização da grade tem sido uma estratégia adotada para aumentar a grade local como também injetar algum dinheiro no orçamento. A pesquisa aponta a necessidade de se ampliar o debate sobre a gestão indireta das emissoras, por meio de fundações.
As representações do masculino nas páginas pornográficas do site Hotboys
Authors: Brasiliense Danielle Ramos , Araújo Victor Antonio
Published: December 2020

Este trabalho busca entender como são construídas as representações do gênero masculino no site pornográfico Hotboys. A partir de uma perspectiva de análise do discurso com base foucaultiana buscaremos demonstrar como determinadas estratégias enunciativas utilizadas na produção das publicações em Hotboys contribuem para um processo de afirmação da performance masculina. Mais especificamente, o artigo investiga a construção e reprodução de estereótipos historicamente construídos sobre o papel do masculino a partir de uma matriz cultural heteronormativa que marca diferenciações entreo homem ativo e o passivo. Nos interessa compreender como um site, que tem como alvo o público gay, produz discursos de virilidade, através do qual valorizam atributos corporais e comportamentais que reiteram o modelo cultural de masculinidade hegemônica. E, ainda, reforçam padrões normativos sobre o masculino colocando o homem afeminado num plano inferior e submisso. Isso acontece porque a heteronormatividade rege o afeto e o sexo, independentemente da orientação sexual. É como se essa norma fosse um guarda- chuva e nós estivéssemos abrigados debaixo dele. É algo mais amplo e mais definidor, uma regra, portanto, vertical que iremos questionar.
“The Cure” in Margary’s The Postmortal: A Vanishing Technological and Transhumanist Mediator Towards an Ageless Existence
Authors: Pacaol Niñoval
Published: December 2020

The 2011 science fiction novel of Drew Magary named The Postmortal drew a world wherein the cure for aging has been scientifically and technologically advanced through gene therapy by the medical practitioner Graham Otto. This paper hinges on the ‘vanishing mediator’ as a theoretical framework synthesized by Kahambing which runs in four distinct stages for its entire process, namely, to: a.) retroactively trace the intervention, b.) evaluate the intervention, c.) identify the mediator, and d.) locate the vanishing point. Applying this to the movement, the methodological structure of the paper is divided into four parts. First, it provides a primary discussion of the social “normal” condition of people in the novel to traceably locate the intervention made by Graham Otto, a doctor, to completely halt the aging process. Second, the researcher presented a technological intervention of gene therapy in the character of Doctor Otto in making a scientific cure for aging. Third, the said intervention is argued to be a vanishing mediator. Finally, it gave a full account of the major implications of a Bostromean transhuman process and its traces in the world at large.
A Descriptive Qualitative Research: Islamic Values in Mandarese Oral Literature (Kalindaqdaq Masaala)
Authors: Marliana Rina , Fachruddin Achmad Taqlidul Chair
Published: December 2020

Kalindaqdaq is a famous oral literature in Mandarese Community in West Sulawesi. This research focused on Kalindaqdaq Masala which is themed on religion. Descriptive qualitative approach is used in this research to find out the Islamic Values in Kalindaqdaq Masala. There were 6 data which have been analized. The data showed that the order to perform Shalah in Islam is clearly implied in Kalindaqdaq Masala. This Research also showed that Kalindaqdaq Masala used as a media to spread the Islamic Values in West Sulawesi.
Typical Features of Politeness Strategy Performed by Anregurutta (Religious Leader in Pappandangan Maros District of South Sulawesi)
Authors: Rani Arham Halwin , Manda Martin L. , Yassi Abdul Hakim , Machmoed Hamzah
Published: December 2020

Politeness has been considered as a core dimension of social interaction regardless of culture and ethnicity and is a predictor of good etique to prevent offensive reactions from  the other interlocutor. The main purpose of this study is to address the politeness strategy use in Buginese Language with special reference to Anregurutta Pappandangan Maros of South Sulawesi. The present research has been set up to account for an ethnographic research and as such research instruments were strictly employed to comply with the nature of resarch design. These include field notes, direct observation, idepth interviews, and recordings. Data were mostly gathered from Anregurutta and the rest from the local people mostly by means of recording and interviews. Greater proportion of the recorded data were from Anregurutta whose daily language of interactional conversation  is in Buginese. The recorded conversations were analyzed by means of descriptive analysis and interpretative paradigm.The analysis came up with a series of findings that partly confirm the validity of previous politeness framework, such as Brown and Levinson (1978), and Yassi (1996)  with reference to Kinship (K), Distance (D) and Power (P). The finding deviates from the universality of politeness pattern that confirm use of bald-on strategy in non-kinship relation. It appears from the study, bald-on strategy was consistently used in kinship pattern, such as Anregurutta and his wife and daughter. (4.1.5 and 4.1.8). This research gap is most probably due to changes in interactional paradigm as a reult of religious values that has affected the way kindship family interacts. The second finding that has been neglected in the study of poliness of which contributes as the research gap is in reference to metalinguistic of politeness that count spritualism and Islamic suphism as generating motives of having to be polite to other people. The finding may contribute the the development of pragmatics with special reference to politeness strategy in non-european context since these aspects have been neglected in previous studies.
Cultural Dimension of Black Representation of Ammatoa Community: Study of Cultural Semiotics
Authors: Maknun Tadjuddin , Tahir M. Dalyan , Suryaningsih Ita
Published: December 2020

One of the community groups in South Sulawesi Province, to be precise in Benteng Hamlet, Tana Toa Village, Kajang District, Bulukumba Regency is known as the Ammatoa community. This community is unique compared to other community groups in Bulukumba Regency, which always appears in black traditional clothes. Of course, this phenomenon raises academic questions as to why the Ammatoa community always appears in traditional black clothes. In fact, apart from always appearing in black, the Ammatoa community also has a white identity color, especially in “pacaka pute” (knee-length pants). However, this paper only focuses on black representations. This paper aims to examine the hidden dimension behind the black representation of the Ammatoa community in Bulukumba Regency, South Sulawesi. To analyze the cultural dimension in question, the semiotic theory of culture is used. Data were collected by means of participatory observation and interviews. The participatory observation method is carried out by directly observing the attitudes and patterns of daily life actions of the Ammatoa community. The interview method was carried out by interviewing the customary leader and several other community members about the cultural system or cultural value that underlies the appearance of the all-black clothing. Both methods are accompanied by audiovisual recording and note-taking techniques. Data were analyzed qualitatively - interpretatively. The results showed that the representation of black in the traditional clothing of the Ammatoa community has a symbolic meaning: (1) human life eventually becomes 'dark'; (2) the attitude of “sabbarak” (patient) , “gattang” (firm), “lambusuk” (honest), and  “pisona” (surrender); (3) “tallasak kamase-mase ri lino” ('living unpretentiously in the world) and “kalumannyang kalupepeang allo ri boko” (rich in the afterlife), “inne lino pammari-mariangji” (this world is just a stopover), “akherak pammantang karakkang” (afterlife is an eternal place) . This concept is embedded in the oral folklore “pasang ri Kajang” 'messages (rules / norms) for the Kajang community'. In addition, there are pairs of signs of opposition (binnery opposotion), namely “pute”' (white) x “lekleng” (black / dark); “ammumba” (rising) x “sakra” (setting); “kamase-mase” (unpretentious) x “kalumannyang” (rich); “singarak” (light) x “sassang” (dark); “lino” ('world) 'x “akherak” (afterlife); “tallasak” (alive) x “mate” (dead).
ANALISA LAJU PERUBAHAN HARGA SAHAM LQ45 MENGGUNAKAN PERSAMAAN DIFERENSIAL
Authors: HSM Zani Anjani Rafsanjani
Published: December 2020

The stock price movement is a very interesting discussion today. Dynamic price changes every time requires deep analysis to determine trends and stock price predictions in the future. There have been many methods used to analyze and predict stock prices. This paper will analyze the acceleration of stock price changes using a mathematical approach, known as a second-order differential equation. The benefit of this research is to obtain a coefficient of change in stock prices that can be used to predict stock prices in the future. Stock prices that will be observed are stocks including the LQ45 category. Furthermore, program analysis is carried out using Matlab software. At the end of the study, the coefficient of price change for LQ45 stocks was generated through provided historical data.
The potential of using of alkaline earth bentonite clays of Ukraine in the production of iron ore pellets
Authors: E Chuprinov , V Lyalyuk , F Zhuravlev , D Kassim , I Lyakhova
Published: December 2020

Objective: to analyze and determine the potential of alkaline earth bentonite clays of Ukraine for use as a binder in the production of iron ore pellets.
Methods: performing rheological studies of bentonite clay samples and their chemical analysis, electron microscopic studies of samples.
Results: the analysis of the chemical composition and requirements for the rheological characteristics of bentonite clays used in the production of iron ore pellets at metallurgical enterprises of Russia and Ukraine is carried out. The swelling indicators and water absorption of monoionic forms of bentonites of some deposits in water of different hardness are given. The quality of pellets with bentonites, that have a different exchange complex, during an industrial water of various hardness usage is examined. The analysis of the mineralogical and chemical composition, as well as the size and composition of the exchange complex of alkaline-earth bentonite clays of the Cherkassk deposit (Ukraine), which has the largest reserves of such clays in the CIS is carried out. It is shown that clays suitable for the production of pellets are located near the surface of the earth. A comparative analysis of the strength characteristics of pellets using bentonites with an alkaline and alkaline-earth exchange complex is presented.
Scientific novelty: it was shown that despite the low swelling of alkaline-earth bentonites, the quality of pellets with these bentonites, in some cases, is slightly lower, and in certain conditions is not inferior to the quality of pellets with alkaline bentonites at the same flow rate.
Practical significance: for real industrial conditions it is shown that the increase in water hardness leads to partial or complete (depending on the value of hardness) replacement of alkaline exchange complex with alkaline earth and conversion of alkaline bentonite clay into alkaline earth with corresponding rheological characteristics, deterioration of lumps and the need to increase the content of bentonite in the charge. In the case of increased hardness of water in the concentrate, it is economically feasible to use in the production of alkaline earth pellets bentonite clay, if it is cheaper than alkaline.
MEDIASI KESENJANGAN ANGGARAN PADA PENGARUH BUDAYA ORGANISASI, ASIMETRI INFORMASI TERHADAP PARTISIPASI ANGGARAN
Authors: Utomo Langgeng Prayitno
Published: December 2020

This study aims to determine the direct effect of information asymmetry and organizational commitment on budget participation through budget gaps and the indirect effect of information asymmetry and organizational commitment on budget participation through budget gaps. The population of this study were all employees at 28 Koperasi Pegawai Republik Indonesia (KPRI). The total sample of 122 respondents was selected through purposive sampling. Methods of data collection through methods using questionnaires and literature study. The results showed that information asymmetry has no direct effect on budget participation. Organizational commitment affects budget participation and organizational commitment affects budget gaps. In addition, organizational commitment and budget participation do not directly affect budget gaps. Information asymmetry and information commitment through budget participation have no effect on budget gaps. Increasing participation in budgeting is considered to reduce budgetary slack. The participation budget can also improve the performance of employees or employees because they feel responsible for the budget that is jointly prepared