bluuebunny/crossref_metadata_2025 huggingface dataset:
Publicar é preciso
Authors: Monteiro Silvio Gomes
Published: May 2018

Editorial Divulgar é precisoSilvio Gomes Monteiro Segundo Hipócrates há uma grande diferença entre saber e crer que se sabe. A Ciência consiste em saber, enquanto que a ignorância está em crer que se sabe. Assim sendo, a Revista de Investigação Biomédica, vem de maneira estoica cumprir a importante missão de divulgar os avanços da ciência nas áreas biológicas e da saúde, assim um maior número de pessoa poderão realmente saber deixando de lado a ignorância do achar que sabe. Apesar da crise econômica e política que passar o País e o baixo investimento que o governo tem disponibilizado as Universidades para o ensino, pesquisa e extensão, as descobertas não podem parar, pois questões são feitas e precisam ser respondidas para que soluções sejam encontradas e divulgadas, por isso o que o lema de todo periódico científico é “divulgar é preciso”, apesar dos pesares, pois a pedra angular das ciências está na curiosidade humana em querer conhecer e aprender mais e mais. Isso explica a maior quantidade de pesquisa que foram enviadas para RIB e com isso ela passou a ser semestral em 2017, mas tem como meta daqui a um ano ou dois anos ser trimestral.  O segundo fascículo do volume 9 da Revista de Investigação Biomédica (RIB), contém os seguintes artigos originais: Avaliação de primers universais bacteriano em PCR in silicoEstudo da interação de diferentes antibacterianos em linhagens de Escherichia coli uropatogênicasVirulência de isolados clínicos de Candida tropicalisPerfil epidemiológico dos casos de intoxicação notificados no Estado do MaranhãoComparação da postura cervical de crianças e adolescentes com e sem disfunção temporomandibularAvaliação do conhecimento sobre a bioequivalência dos fármacos em uma Universidade particularRepercussões no neonato da utilização de redes de descanso e posição pronoPerfil epidemiológico de idosas vinculadas a um clube de repousoAvaliação da qualidade de vida de idosas vinculadas a um clube de repouso E 4 artigos de revisão, cujos temas abordados são: Perfil microbiológico bucal dos pacientes portadores de osteonecrose maxilar induzida por bisfosfonatosÓleo essencial da Canela (Cinamaldeído) e suas aplicações biológicas.Os fatores de riscos envolvidos no desenvolvimento da hipertensão infantil e suas consequênciasContribuições da atenção farmacêutica á pacientes em tratamento oncológico Desse modo, toda a equipe da RIB  deseja a todos os leitores boas leituras e descobertas.
Nghiên cứu đánh giá hiện trạng và đề xuất giải pháp kiểm soát chất thải rắn sinh hoạt tại thành phố Pleiku
Authors: Nguyễn Minh Kỳ
Published: May 2018

Mục đích của nghiên cứu nhằm đánh giá hiện trạng và đề xuất giải pháp kiểm soát chất thải rắn sinh hoạt tại thành phố Pleiku. Tổng lượng chất thải rắn tăng qua các năm trong giai đoạn 2012-2016 với lần lượt 35.386; 38.689; 43.243; 46.900 và 50.737 tấn/năm. Quá trình phân tích cho thấy thành phần chất thải hữu cơ và chất có thể cháy chiếm tỷ lệ nhiều nhất, lần lượt chiếm 62% và 22% khối lượng. Kết quả nghiên cứu cho thấy, công tác xử lý chất thải rắn hiện nay của thành phố Pleiku bằng bãi chôn lấp đang gây ô nhiễm cho nguồn nước, gây mùi khó chịu, mất mỹ quan sinh thái. Việc chôn lấp chất thải rắn sinh hoạt tốn nhiều diện tích đất trong khi nhu cầu sử dụng đất cho các mục đích khác ngày càng tăng. Thành phần, khối lượng chất thải rắn sinh hoạt trên địa bàn thành phố phù hợp với các chỉ tiêu của công nghệ MBT-CD.08. Việc áp dụng công nghệ MBT-CD.08 vào xử lý chất thải rắn sinh hoạt không những giải quyết được các vấn đề môi trường, xã hội mà còn đem lại hiệu quả về mặt kinh tế từ các sản phẩm được tạo ra từ chất thải rắn.
Nghiên cứu biểu hiện và tinh chế -glucuronidase có nguồn gốc vi khuẩn dạ cỏ dê trong tế bào Esccherichia coli
Authors: Do Huyen
Published: May 2018

α-1,2-Glucuronidase GH67 là enzyme có khả năng phân cắt chuỗi bên 4-O-methylglucuronic acid ((Me)GlcA) trong glucuronoarabinoxylan để làm tăng chuyển hóa lignocellulose thành đường đơn cho lên men sản xuất cồn và các chất có giá trị từ sinh khối thực vật. Trong nghiên cứu này, gen Gglc1 dài 1908 nucleotide mã hóa cho enzyme α-1,2-glucuronidase GH67 trưởng thành có nguồn gốc từ vi khuẩn trong dạ cỏ dê đã được biểu hiện thành công trong chủng E. coli Roseta. Hầu hết enzyme được biểu hiện dưới dạng tan khi chủng tái tổ hợp được nuôi cấy trong môi trường TB, PE có 0,05 mM IPTG ở 25oC, 30oC. Enzym được tinh chế thành công bằng sắc ký ái lực với độ tinh sạch 90%. Hoạt tính của enzyme đã được đánh giá sơ bộ dựa trên sự chuyển hóa (Me)GlcA trong birchwood xylan thành 4-O-methyl-D-glucuronic acid và D-glucuronic acid làm thay đổi pH dung dịch và được phát hiện bằng bromothymol blue. Enzyme sẽ được tiếp tục đánh giá tính chất để xem xét khả năng bổ sung vào hỗn hợp enzyme cho chuyển hóa hiệu quả sinh khối thực vật thành đường.
The THE ECOLOGICAL QUALITY STATUS OF THE ORGANIC SHRIMP FARMING PONDS: USE OF A NEW BIOTIC INDICES
Authors: Thành Thái Trần
Published: May 2018

In spite of the development and widespread dissemination of the model organic shrimp farming systems, the biological communities in the organic shrimp farming ponds have still very limited. Therefore, we conducted a field survey for macrobenthic communities (MC) of the Tam Giang‘s organic shrimp farming ponds (TGOSFP) located in Tam Giang commune, Nam Can district, Ca Mau province during three seasons in 2015 (March - dry, July - transfer and November - wet season). The results indicated that the MC have characterized by high density and slightly diversity that is a rich natural food sources for shrimp in the TGOSFP. Further more, the present study is a first attempt to use of new indices (AMBI - AZTI’s Marine Biotic Index) on MC for determining the ecological quality status of sediment (EcoQ) in the TGOSFP. The following results were also recorded with an undisturbed and slightly disturbed  EcoQ in the TGOSFP and the general EcoQ would likely be improved between three seasons. The success of AMBI for detecting EcoQ in Vietnam is specific to this study, but AMBI was likely to improved, in particular tropical regions.
CURRÍCULO: DESENHOS, DESAFIOS E PERSPECTIVAS. A PROPOSTA CURRICULAR DE UMBUZEIRO - PB PARA O CICLO DE ALFABETIZAÇÃO
Authors: Silva José Rogério da
Published: May 2018

O trabalho apresenta uma reflexão acerca da Proposta Curricular para o ciclo de alfabetização dos Anos Iniciais do Ensino Fundamental, da Secretaria Municipal de Educação de Umbuzeiro – PB, uma coletânea de orientações e sugestões que possam contribuir para a prática em sala de aula. Uma propositura de se imprimir um parâmetro de trabalho comum às escolas do Sistema Municipal de Ensino. Considerando ainda as especificidades da Alfabetização e do Letramento presentes nos anos iniciais, em cada escola e no interior da sala de aula, se optou por organizar os conhecimentos em ciclos, sendo que o primeiro contempla os três primeiros anos do Ensino Fundamental – Anos Iniciais (1º, 2º e 3º anos de escolaridade), como escopo da abordagem o componente curricular de língua portuguesa. Dentro de uma lógica e organização que introduz, retoma, trabalha e consolida os conhecimentos escolares, visando favorecer o desenvolvimento das capacidades e habilidades, sob seis grandes eixos. Em meio a uma abordagem histórica e teórica do currículo no Brasil, do processo de alfabetização e letramento, sempre fazendo um contraponto com a Proposta Curricular do Município de Umbuzeiro – PB, sempre em uma perspectiva de pesquisar/debater/ refletir acerca do tema.
DIVERSIDADE SEXUAL E GÊNERO: CONCEPÇÕES DE ADOLESCENTES E O TRABALHO EDUCATIVO EM SAÚDE
Authors: Theodoro Mikhael Dos Santos , Brunini Bárbara Cossettin Costa Beber
Published: May 2018

A definição da identidade do ser humano inicia-se na adolescência, fase que molda o caráter, o saber, e o intelecto individual. A educação nessa fase torna-se essencial, principalmente em relação à saúde do adolescente. Sabe-se que o enfermeiro é legal e eticamente responsável pela educação em saúde, conhecedor também da população local, e de suas realidades. O objetivo do presente estudo foi compreender como a diversidade sexual e as relações de gênero são produzidas e reproduzidas por meio da revisão de literatura e como a atuação do enfermeiro enquanto educador pode ser diferencial na educação sexual. Investir na saúde da população adolescente e jovem é custo efetivo porque garante também energia, espírito criativo, inovador e construtivo dessas pessoas, que devem ser consideradas como um rico potencial, capaz de influenciar de forma positiva o desenvolvimento do país. Conclui-se assim que é importante que o enfermeiro realize educação em saúde com os adolescentes para contribuir com seu crescimento intelectual, respeitando suas escolhas e permitindo que o autocuidado aconteça de fato, assim os adolescentes podem tornar-se mais independentes em sua saúde e bem-estar.
AÇÃO COLETIVA COMO FORMA DE AGREGAÇÃO NO SISTEMA AGROINDUSTRIAL DA AQUICULTURA DE MARIPÁ-PR
Authors: Pasini Andreia Helena , Schmidt Carla Maria , Rocha Jr Weimar Freire da , Tomio Marialva
Published: May 2018

Este artigo tem como tema a ação coletiva desenvolvida pelos agricultores familiares da Cidade de Maripá, no estado do Paraná. O objetivo da pesquisa foi compreender quais os benefícios que tornam a ação coletiva uma estratégia viável para os produtores da Aquimap ao longo do tempo, identificando quais as variáveis que apresentam influência sobre a viabilidade da iniciativa coletiva investigada. Como objeto de estudo, investigou-se o sistema agroindustrial da piscicultura, especificamente a Associação de Aquicultores de Maripá (Aquimap). Os dados empíricos foram coletados através de entrevistas (que foram gravadas e transcritas), questionários aplicados aos produtores e registros. Esses dados foram coletados com os associados da Aquimap e com o técnico da Emater da cidade. Os dados foram analisados de forma descritiva. Os resultados apontaram que a maioria das variáveis pesquisadas é positiva para a ação coletiva em estudo. Porém no que se refere a homogeneidade e laços fortes, observou-se como negativa para o estudo, apesar de se apresentar como negativa, o caso empírico obtém sucesso. Ainda cumpre destacar que a ação coletiva obtém sucesso ao longo do tempo, e os pequenos produtores familiares tem se mantido com a produção de peixes. Esse estudo apresenta contribuição significativa para os estudos de ação coletiva, identificando as variáveis que podem ser consideradas indutoras do sucesso ou falha de uma ação.PALAVRAS-CHAVE: Ação coletiva. Agricultura familiar. Sucesso. Benefícios.
Investigating effects of ball size on the performance of gas lift valve for both modified and optimized seats
Authors: Kabir Ehsanul , Emadi Hossein , Elldakli Fathi , Young Matt
Published: May 2018

The seat and the ball are the only two components of a Gas Lift Valve (GLV) that can be switched out to meet changing gas throughput requirements. For this reason, individual pairings of balls and seats must be designed to meet the particular requirements of specific situations. While conventional GLV seats have sharp edges, a modified seat design with partially beveled edges has been shown to improve gas throughput. This design was then tested using benchmark valve and was optimized by beveling the entire port of the seat. These experiments were conducted using a ball diameter that was 0.0016 m larger than the diameter of the port top, although the effects of even larger ball sizes have also been studied using benchmark valves with conventional seats. Researchers have yet to explore the effects of ball diameters smaller than the Port Top Diameter (PTD) and larger than the Port Bottom Diameter (PBD) for modified and optimized seat designs. In this paper, the effects of smaller ball size on the GLV gas throughput have been analyzed using both modified and optimized seat designs and actual GLV. The ball was 0.0016 m smaller than the PTD of the seats. Geometric models have been deduced to calculate the generated upstream area (frustum area) open to flow. This frustum area is a function of stem travel, and the dimensions of the seat and ball. Theoretical calculations have been compared with results obtained through robust experimental methods. The entire experimental program was divided into four individual experiments. The static testing was used to fix the dome pressure and the opening pressure. The hysteresis effect associated with the bellows assembly was minimized using the aging procedure. Probe tester was used to measure the stem travel. Finally, the gas throughput of the GLV was measured using dynamic testing. The smaller ball sizes were found to significantly improve the gas throughput of actual GLV. This improvement was as high as 179% for large PBD seats. However, the frustum area practically decreased for these cases. This result suggests that the flow coefficient has more effect on GLV gas throughput compared to frustum area.
İNCİR İHRACATINI ETKİLEYEN FAKTÖRLER: AYDIN ÖRNEĞİ
Authors: KIRICI Nurhan
Published: May 2018

İncir önemli bir besin
kaynağı ve sanayi hammaddesidir. Türkiye, dünyada incir üretiminde ilk sırada
yer almakta olup, üretilen incirler yaklaşık yüz ülkeye ihraç edilmektedir.
Ancak Türkiye’nin incir ihracatından elde ettiği gelir düşüktür. Bu durum, incir
ihracatında katma değeri yüksek ürünlere yönelinmesi, marka değeri olan
ürünlere ağırlık verilmesi ve uluslararası pazarlama stratejilerinden doğru
biçimde yararlanılması gerektiğini göstermektedir. Bunun için, küreselleşmenin,
ekonomik entegrasyon ve işbirliklerinin arttığı, dış ticarette rekabetin
yükseldiği 21. yüzyılda, incir üreticilerinin de Ar&Ge ve inovasyonla
kendini yenilemeleri gerekmektedir. Bu çalışmada; Aydın’da incir ihracatı yapan
firmalara yüz yüze anket uygulanmış ve elde edilen veriler SPSS programı ile
analiz edilmiştir.  Analiz sonucunda;
Ar-ge ve inovasyona önem veren, uluslararası tescilli markası olan, gıda analiz
laboratuvarına sahip bulunan ve uluslararası fuarlara katılan firmaların
ihracat performanslarının daha yüksek olduğu tespit edilmiştir.
Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
Authors: Guo Tiannan , Li Li , Zhong Qing , Rupp Niels J , Charmpi Konstantina , Wong Christine E , Wagner Ulrich , Rueschoff Jan H , Jochum Wolfram , Fankhauser Christian Daniel , Saba Karim , Poyet Cedric , Wild Peter J , Aebersold Ruedi , Beyer Andreas
Published: May 2018

It remains unclear to what extent tumor heterogeneity impacts on protein biomarker discovery. Here, we quantified proteome intra-tissue heterogeneity (ITH) based on a multi-region analysis of prostate tissues using pressure cycling technology and Sequential Windowed Acquisition of all THeoretical fragment ion mass spectrometry. We quantified 6,873 proteins and analyzed the ITH of 3,700 proteins. The level of ITH varied depending on proteins and tissue types. Benign tissues exhibited more complex ITH patterns than malignant tissues. Spatial variability of 10 prostate biomarkers was validated by immunohistochemistry in an independent cohort (n = 83) using tissue microarrays. Prostate-specific antigen was preferentially variable in benign prostatic hyperplasia, whereas growth/differentiation factor 15 substantially varied in prostate adenocarcinomas. Furthermore, we found that DNA repair pathways exhibited a high degree of variability in tumorous tissues, which may contribute to the genetic heterogeneity of tumors. This study conceptually adds a new perspective to protein biomarker discovery: it suggests that recent technological progress should be exploited to quantify and account for spatial proteome variation to complement biomarker identification and utilization.
Pretesting a survey instrument of adoption elements in network environment on cloud services - eLearning case study
Authors: Abdul Aziz Azlinda , Osman Salyani , Widyarto Setyawan , Mohd Suradi Nur Razia , Handan Rahayu , Arbain Mohd Noor Rizal , Marjudi Suziyanti
Published: May 2018

Abstract–The success factor elements adoption in a network environment on cloud services by Institution of Higher Institution (IHI) is essential to be defined appropriately. Most of the IHI know the advantage in using network environment on cloud services but they still fears to utilize it because of lack of awareness, guideline and experience. In this study, the success factor elements in using eLearning at network environment on cloud services are defined and retrieve from the literature. The elements defined from the literature were validated by the expert at the preliminary studies. The expert came from the institutions that have experience in used cloud services for an identified the accuracy of the elements. The clear elements define are purposed and stated as important elements. The designing of the questionnaire survey are made base on the elements defined. The output were getting onward will be used as elements of designing in proposed a guideline for Higher Learning Institution in selected the correct eLearning network environment by using cloud services. This paper went thru the step at the designing questionnaire survey. The content and construct validity were done by the reviewer expert in the different fields. The experts were checking the validity of the questions. The questionnaire survey was revise base on the comments of the experts. The understanding and reliability of questionnaire were getting as a final stage before distributed to the pilot study. This paper will depict an impact of the questionnaire survey development in getting the comprehensive and understanding the question onward get the smooth process at the pilot test for get the actual result.
IbM Penyulingan Minyak Kayu Putih dan Briket Arang di Desa Delo dan Raekore
Authors: Ully Dedy Nataniel , Wuwur Bernadus
Published: May 2018

Villagers of Delo and Raekore have a traditional eucalyptus refining business by boiling the eucalyptus leaves for aromatic oils. Eucalyptus oil produced quite well, it's just a long distillation process that is 5 to 6 hours so it requires a lot of wood. While the availability of firewood in the forest is currently quite difficult, so people often cut down trees in the forest. So need to find a solution by changing the way of boiling by steam method and using charcoal  fuel made from coconut shell, because it has a higher calorific value than the shell is burned directly. Traditional refined eucalyptus oil products, ranging from 2 to 3 beer bottles   (1 bottle of beer = 350 ml) per day, so that through the activities of IbM can apply the appropriate technology products that is the installation of wood crude oil refinery by steam method and the using of briquette fuel. The steamed container produced has a volume of 160 liters while the charcoal briquette printing device is capable of printing 8 charcoal briquettes in one print. The using of refinery installations by steam method and charcoal charcoal fuel, can increase the production capacity of eucalyptus oil  to encourage economic improvement of Delo and Raekore villagers. The eucalyptus refining oil refinery has a production capacity of 4 to 5 bottles of beer (1 bottle of beer = 350 ml) per day and charcoal briquette presses have a production capacity of 8 charcoal briquettes.
TRAINING OF SCIENTIFIC PAPERS WRITING FOR HIGH SCHOOL TEACHER TO IMPROVE THE QUALITY OF THE TEACHER
Authors: Herowati Rina , Widodo Gunawan Pamuji , Supriyadi Supriyadi , Sunarti Sunarti , Keswara Yane Dila , Purnamasari Nuraini Dewi
Published: May 2018

ABSTRACTThe professional development of the teachers through the writing of scientific papers needs to be improved. The obstacle faced by teachers so they did not write scientific paper mainly are caused by limitation of time and not understanding the rules of writing a scientific paper. This devotional activity aims to improve  teachers' motivation to write scientific papers and improve the ability for the teachers to write scientific papers to produce as many articles as published in scientific journals. The method used is situational analysis by interviewing the principal and distributing questionnaires. Furthermore, the preparation of materials, lectures and discussions, as well as accompaniment of scientific writing until the participants successfully publish their articles in scientific journalsKeywords: quality improvement, scientific papers, teachers ABSTRAKPengembangan profesionalitas guru melalui penulisan karya ilmiah perlu ditingkatkan. Kendala yang dihadapi guru sehingga tidak menulis karya ilmiah terutama adalah belum ada waktu dan belum paham aturan penulisan karya ilmiah. Kegiatan pengabdian ini bertujuan untuk meningkatkan motivasi guru menulis karya ilmiah dan  meningkatkan kemampuan guru menulis karya ilmiah hingga dihasilkan sebanyak mungkin artikel yang dipublikasikan di jurnal ilmiah. Metode yang dilakukan adalah analisis situasi dengan wawancara dengan kepala sekolah dan penyebaran kuesioner.  Selanjutnya dilakukan penyusunan materi, ceramah dan diskusi, serta pendampingan penulisan karya ilmiah hingga peserta berhasil menerbitkan artikelnya di jurnal ilmiah.KataKunci: guru, karya ilmiah, peningkatan kualitas
HBeAg positive chronic HBV with persistent normal ALT: Not treat now
Authors: Leerapun Apinya
Published: May 2018

Chronic hepatitis B virus infection is a major cause of cirrhosis and hepatocellular carcinomaworldwide. Antiviral treatment can safely and effectively suppress viral replication and reduce riskof disease progression but need long term therapy. However, understanding the natural history ofhepatitis B virus infection is important when deciding whether to treat or not to treat the patients.On the basis of virus-host interaction, the natural course of HBV infection can be divided into four phases.The elevation of alanine aminotransferase (ALT) level is an important indicator of immune-mediatedinflammation to eliminate HBV infected hepatocyte. The individual patients with normal ALTare assume to be the immune tolerance phase and low risk to disease progression.

 

Figure 1 ระยะของการติดเชื้อไวรัสตับอักเสบบีชนิดเรื้อรัง

 

Keywords: chronic hepatitis B, HBV, ALT
Asymptomatic chronic hepatitis C with F0-1 fibrosis: Treat now
Authors: Sethasine Supatsri
Published: May 2018

Patients with chronic hepatitis C with no or minimal liver fibrosis (F0-F1 Fibrosis) were 50% of the entire group of patients with chronic hepatitis C. Although this group of patients might have to defer treatment due to treatment prioritization strategy, as the excellent performance of regimens with few side-effects, if in the future they would have access the treatment, the number of patient with chronic hepatitis C would decrease dramatically. After following up with treatment-naive patients for five years, 60% of them had the fibrosis progression. Patients with minimal fibrosis had possibility of advanced fibrosis at 30%. Findings indicated that the infection in the old aged patient, infection for long period, chronic hepatic inflammation, steatosis, insulin resistance and alcohol drinking affected the rapid fibrosis progression. Having treatment from F0-F1 stage was count for the long-term benefit as it reduced the development of advanced fibrosis for 15% and the survival rate at 15 years better than the non - treatment group, since it minimized the chance of cirrhosis and the extrahepatic mortality.After viral eradication, it would minimize health service and following up expenses on chronic patients.Symptom conditions such as fatique, impaired cognitive function, obsessive-compulsive, depression,and anxiety were improved that affected the better quality of life. The expenses and longer quality-adjustlife year of the treatment from minimal or no fibrotic stage should be taken into account comparingwith the treatment from significant fibrotic stage according to the health economic evaluation.Early treatment in patients with minimal or no fibrotic stage who had factors affecting the rapidfibrosis progression would result in cost-effectiveness.

 

Keywords: chronic hepatitis C, fibrosis progression, cost-effectiveness, quality-adjust life years, increment cost effectiveness ratio
Синтез и биологическая активность 2-амино-1-арил-5-(3,3-диметил-2-оксобутилиден)-4-оксо-N-(тиазол-5-ил)-4,5-дигидро-1H-пиррол-3-карбоксамидов
Authors: Зыкова Cветлана Сергеевна , Игидов Назим Мусабекович , Захматов Антон Викторович , Киселев Максим Андреевич , Галембикова Айгуль Рафиковна , Хуснутдинов Рамазан Рахматулаевич , Дунаев Петр Дмитриевич , Бойчук Сергей Васильевич , Чернов Илья Николаевич , Родин Игорь Алексеевич
Published: May 2018

Взаимодействием 4-ариламино-2-трет-бутил-2,5-дигидро-5-оксофуран-2-илацетатов (Ia – з) с 2-циано-N-(тиазол-2-ил)ацетамидом в присутствии триэтиламина синтезирован ряд новых производных 2-аминопиррола – 2-амино-1-арил-5-(3,3-диметил-2-оксобутили- ден)-4-оксо-N-(тиазолил-5-ил)-4,5-дигидро-1H-пиррол-3-карбоксамиды (IIа – з). Исследована биологическая активность полученных соединений. Обнаружено, что синтезированные соединения обладают низкой токсичностью, а 2-амино-1-(2-бромфенил)-5-(3,3-диметил-2-оксобутилиден)-4-оксо-N-(тиазол-5-ил)-4,5-дигидро-1H-пиррол- 3-карбоксамид (IIб) и 2-амино-1-(2,4-дихлорфенил)-5-(3,3-диметил-2-оксобутилиден)- 4-оксо-N-(тиазол-5-ил)-4,5-дигидро-1H-пиррол-3-карбоксамид (IIж) проявляют радикалсвязывающую активность, превышающую таковую тролокса, и цитотоксическую активность, обнаруженную по отношению к опухолевым клеточным линиям гастроинтестинальных стромальных опухолей (ГИСО), в том числе резистентным к таргетному препарату иматинибу (гливеку). Цитотоксическая активность данных соединений сопоставима с действием химиопрепаратов доксорубицина и существенным образом превышает эффект этопозида, паклитаксела и гидроксимочевины. Одним из возможных молекулярных механизмов действия вышеуказанных соединений является их способность нарушать процессы клеточного деления, индуцировать селективное накопление клеток в М-фазе клеточного цикла и последующую гибель по механизму «митотической катастрофы».
Растворимость и стабильность пророксана при разных значениях pH
Authors: Кречетов Сергей Петрович , Нифонтова Галина Олеговна , Долотова Ольга Владимировна , Веселов Марк Сергеевич
Published: May 2018

Исследованы растворимость и стабильность неселективного α-адреноблокатора 1-(2,3-дигидро-1,4 бенздиоксин-6-ил)-3-(3-фенил-1-пирролидинил)-1-пропанона гидрохлорида (пророксана) при различных pH. Показано, что в области 3 < pH < 5,5, соответствующей протонированной форме, имеет место снижение растворимости пророксана, не характерное для солей органических оснований, и увеличение его разрушения. Выдвинуто предположение, что выявленная особенность свойств пророксана в водных растворах может отражать образование комплексов его протонированных и непротонированных молекул. Полученные результаты указывают на необходимость разработки препаратов пророксана с использованием лекарственных форм и систем доставки, обеспечивающих его максимальное усвоение в желудке.
Risperidon Kullanımına Bağlı Ortaya Çıkan Akut Toksik Hepatit: Olgu Sunumu
Authors: Gündüz Nermin , Turgut Celaleddin
Published: May 2018

İlaca bağlı karaciğer hasarı, hafif biyokimyasal değişikliklerden akut karaciğer yetmezliğine kadar uzanan klinik bir durumdur. Hepatik yan etkilerden sorumlu ilaçların %16’sı nöropsikiyatrik ilaçlardır. Risperidon psikotik bozuklar ve duygudurum bozuklarının tedavisinde sıklıkla kullanılan, serotonin tip 2 (5HT2) ve dopamin tip 2 (D2) almaçları üzerine antagonistik etki gösteren ikinci kuşak antipsikotiktir. Risperidon tedavisi sırasında KC enzimlerindeki yükselme prevalansı %01-1 olarak bildirilmiştir. Risperidon tedavisi alan hastalarda görülen hepatik yan etkilerin ciddiyeti ve sıklığı daha az olmasına rağmen risperidona bağlı nadiren karaciğer hasarları bildirilmiştir. Biz bu yazıda Bipolar Bozukluk tanılı genç bir kadın hastada risperidon tedavisi sonrası gelişen akut toksik hepatit vakasını paylaşmayı değer bulduk.
Cerrahi Hastalarının Sağlık Bilgisine Ulaşmada İnternet Kullanım Özellikleri
Authors: ÇETİN İbrahim , ÖZHANLI Yasemin
Published: May 2018

Amaç: Cerrahi tedavi önerilen hastalar
sağlık durumları ile ilgili bilgi gereksinimlerini artan bir eğilimle İnternet
üzerinden karşılamaya çalışmaktadır. Bu çalışmada tedavisi cerrahi kliniklerde
devam eden hastaların İnternet üzerinde sağlık bilgisi arama özelliklerini
belirlemek amaçlanmıştır.Yöntem: Tanımlayıcı tipteki bu araştırmanın
örneklem grubunu 9 cerrahi klinikte bulunan 219 hasta oluşturmaktadır.
Çalışmanın verileri 39 soruluk bir anket formu ile toplanmıştır.Bulgular: Hastaların başlıca ve en yararlı
gördüğü bilgi kaynağı hekimdir. Hastaların yarısından fazlası hemşirenin
klinikte çeşitli düzeylerde bilgilendirme yaptığını ifade ederken %76,9’u
içeriğini hemşirelerin hazırladığı web sitelerinden sağlık bilgisi edinmek istediklerini
belirtmiştir. Çalışmaya katılan tüm hastaların %46,1’inin, İnternet kullanan
hastaların ise %97,1’inin çevrim içi sağlık araştırması yaptığı saptanmıştır.Sonuç: Hastaların önemli bir bölümü sağlık
bilgisi aramada İnternet kullanmaktadır. Az sayıda katılımcıların İnternet
üzerinde yer alan sağlık bilgilerinin çarpıtılmış ya da yanlış olabileceğini
ifade etmesi kaygı verici bir bulgudur.
Jorge Eduardo Levin : “Acuarelas de nuestra tierra”
Authors: Gándara Nicolás
Published: May 2018

Médico cirujano. 63 años. Nacido en Bella Vista – Corrientes, Argentina.

Autodidacta. Mi inspiración supongo que viene de mis años pasados en el campo de niño. Durante años solo pinte caballos y desnudos femeninos. Actualmente mi relación con el campo es más estrecha porque tengo un haras de caballos. Pinto acuarela por la inmediatez del medio. En unas horas puedo ver el resultado de lo que hago.

Pinto en el consultorio después de hora. Cuando me preguntan porque elijo algunos temas

contesto con una anécdota de Galeano escritor uruguayo, que decía que iba a un bar donde siempre había un negro tocando tambores y un día le pregunto cuando tocaba y le contesto “cuando me pica la mano”. Puedo ver mil paisajes y figuras y no me explico pero algunas me provocan ganas de pintarlas. Mi estilo es figurativo casi realista. Y uso mucho pigmento. La acuarela lavada no me gusta mucho. Uso papeles de muy buena calidad de 300 gr. En adelante, pinceles de pelo de marta y acuarelas de varias marcas de tipo profesional. Mi tamaño preferido es 30 x 40 cm.
ANALISIS IMPLEMENTASI PRINSIP KEADILAN DALAM PROSES PENYELESAIAN KEBERATAN PAJAK PADA DIREKTORAT JENDERAL PAJAK
Authors: Sari Devi Purnama
Published: May 2018

This research is performed to analyze if Tax Objection process has fulfilled the equity principle, to find obstacles in fulfilling the equity principle in the Objection process and also to find the ideal model of Tax Objection Process so that equity principle can obtained by the tax payers. The research is performed using qualitative method through observation, documentation study and interviewing 10 experienced informants in taxation. According to the research known that the equity principle has not been fulfilled in the Objection process, these happens because of some obstacles for instance the psychological matter met by the tax authority whom have to fulfill revenue target from tax payers, lack of understanding from both Tax payers and fiscus regarding tax regulations, the DGT internal policy to “Decline” any of Tax Objection request from Tax payers and also traumatic problem of fiscus for having GT-like case and/or criminalization case of tax authority by the DGT. Finally, the ideal model proposal concerning Tax Objection Institution is to shifted from DGT to be directly under the Ministry of Finance or upgraded the institution to be a pure court in the environment of justice power by establishing Tax Court Level I and the existing Tax Court to be a Higher Tax Court.
KEPENTINGAN KEBIJAKAN PEMBUATAN PERATURAN DAERAH PROVINSI DAERAH KHUSUS IBUKOTA (DKI) JAKARTA NO. 4 TAHUN 2007 (PENGENDALIAN, PEMELIHARAAN DAN PEREDARAN UNGGAS) DAN IMPLIKASINYA TERHADAP USAHA PENDISTRIBUSIAN UNGGAS DI DKI JAKARTA
Authors: Mariam Siti
Published: May 2018

This research was conducted to find out the following matters: (1) the juridical, philosophy, and sociology aspects of DKI Jakarta Province regulation on poultry distribution, (2) observing and analyzing the poultry   relocation and distribution in DKI Jakarta Province, (3) analyzing the implication of local regulation number 4 year 2007 in poultry business.This research was conducted based on local regulation number 4 year 2007 which was supported by legal documents from competence resources in poultry business. The data collected was supported by library research, scientific literatures, books, scientific magazines/journals, statistic data, scientific articles, and reports, and interview to the poultry businessmen. The data was analyzed by using qualitative and quantitative methods due to the type of this research as descriptive study and was legal normative research study.The discussion came to the finding that the importance of composing local regulation policy in DKI Jakarta Province number 4 year 2007 was to prevent the disseminating and the spreading of avian influenza in order to protect the community and to provide economic opportunity for local government or private sectors to manage the chicken accommodating location (TpnA) and the chicken butchering location (TPA) in order to get income. By deciding the TpnA and TPA in five location, it caused the accommodation and the butchering industries more concentrated and decrease the competition intensity in poultry business. PT Kartika Eka Dharma in west Jakarta and PT Dharma Jaya as well as PD Dharma Jaya that were appointed as chicken butchering location and chicken accommodating location operators became the form of government discrimination toward the poultry businessmen.
“ANALISIS IMPLEMENTASI KEBIJAKAN E-FAKTUR DALAM UPAYA PENINGKATAN PENERIMAAN NEGARA PADA KPP PRATAMA TEBET TAHUN 2016”
Authors: Rachmatulloh Idar , Pamungkas Putri Y
Published: May 2018

In 2013 - 2014 value an invoice tax fictitious up by Rp.150.600.000.000,00, for that Direktorat Jenderal Pajak is trying to create E-Faktur for the purpose of removing the number of an invoice tax fictitious would encourage state revenues. This research in its implementation use the theory Edward III. In this research researchers want to know the implementation of E-Faktur that had taken from the beginning experiments on Java and Bali in 2015 and are valid nationwide in July 2016 .In this research researchers used research methodology qualitative is data analysis the discussion descriptive comparing between the realization of with the potential E-Faktur related state revenues. The research, in 2015 when E-Faktur applied the first phase in Java and Bali increase from 2014 where E-Faktur has not been applied yet. And on 2016 when E-Faktur set of the national scale, state revenues increase to 12,40 % .This explains that E-Faktur can help to improve state income.
PENGARUH MOTIVASI DAN BUDAYA ORGANISASI TERHADAP PRODUKTIFITAS KERJA KARYAWAN ( STUDI KASUS DI PT BOOGI AVINDO, BOGOR)
Authors: Prayogo Arif
Published: May 2018

This study was taken from the thesis research aims to analyze how much Influence Motivation and Cultural Organization on labor productivity Employees (Case Study in PT Boogi Avindo, Bogor). The study is based on the phenomenon, which showed a decrease in employee productivity, one of them due to low employee motivation, and poor corporate cultureThe sampling method used is simple random sampling. The sample in this study followed the formula Slovin, or as many as 35 employees.Data that has met the test of validity and reliability further processed to produce a regression equation 0.242+ 0286 X1 + 0.699 X2, where Y is the variable Employee Productivity, Motivation X1 and X2 are the variables are variables Organizational Culture. Hypothesis testing using t test showed that each of the independent variables studied was shown to significantly affect the dependent variable partially on Employee Productivity. Motivation partially positive effect on Work Productivity indicated by the r value of 0815 which means a strong relationship between them. Organizational culture is partially positive effect on Work Productivity indicated by the r value of 0.747, which means a strong relationship between them. Motivational variables simultaneously and Cultural Organization has a significant influence on Work Productivity indicated by the r value of 0.776 which means the relationship between them is very strong. While the value of the coefficient of determination (R2) is equal to 0.602, which means that motivation together with Cultural Organization may explain the variable Work Productivity by 60, 2%, while the remaining 39.8% is explained by other variables.
ANALISIS EFISIENSI BIAYA PERBANDINGAN METODE LCL DAN KONSOLIDASI PADA PROSES IMPOR KOMPONEN PT CATERPILLAR INDONESIA DARI CHINA DAN JEPANG
Authors: Nashir Achsanul
Published: May 2018

Facing an era of free trade, governments and businesses must continue to increase growth across sectors such as trade, investment, and so forth. Indonesia's economic competitiveness globally in 2013 rose three ratings compared to the previous year. This is also the case in the heavy equipment market, especially PT Caterpillar Indonesia. PT Caterpillar Indonesia is facing increasingly tight competition with other heavy equipment manufacturers, both from domestic and abroad.In this research will discuss trucking, storage, freight, and duty by PT Caterpillar Indonesia in order to save and cost efficiency. The approach used is descriptive qualitative research. The authors also want to lift the phenomenon and obstacles that exist in the implementation of management systems, trying to find a discussion of existing problems and describe the descriptive research results that have been achieved.The data shows that there is a difference in the average cost efficiency of storage compared to LCL method consolidation method by 40.35%. For the difference in average cost efficiency of trucking compared to LCL method consolidation method by 24%. While there is no difference in the average cost efficiency of freight over the LCL consolidation method. Finally there is an overall average cost efficiency difference compared to consolidation method with LCL method of 15.62%.
PELESTARIAN RAWON NGULING SEBAGAI NILAI TAMBAH PADA PENGEMBANGAN WISATA KULINER TRADISIONAL INDONESIA
Authors: Ayuningsih Sri Fajar
Published: May 2018

Rawon is a typical food from East Java. Appearance of this meat soup is typical with blackish-colored sauce for wearing kebwak spice. Rawon Nguling's restaurant in Probolinggo is one of the most famous culinary destinations. This restaurant has been around since 1942 and now has 11 franchised restaurants in several cities in Indonesia. As one of the traditional culinary wealth, Rawon Nguling is worth preserving. For that required a proper development step by using the standard approach of spice Rawon Nguling and cooking techniques that is more practical ie freezing spices. From the result of research, Rawon Nguling standard spice (Rawon Nguling-Fajar seasoning) frozen up to 15 days in research scale, proved to be able to produce spice Rawon Nguling with flavor, smell / flavor, and color that is not different from Rawon Nguling fresh standard . In the form of frozen spices, the Rawon Nguling spices become more practical, more durable stored, and allow to be preserved. From the results of proximate analysis, Rawon Nguling is a food with a complete nutritional composition, especially as the fulfillment of animal protein requirements of 52.2% of AKG. In addition, spices in Ngurah Rawon cuisine also contain a variety of bioactive compounds that are good for maintaining health, including antioxidants, antimicrobial, antidiabetic, antitumor, and other functions.
MEMPROMOSIKAN BIR PLETOK SEBAGAI MINUMAN KHAS BETAWI MELALUI PENYAJIAN SEBAGAI WELCOME DRINK
Authors: Muliani Lila
Published: May 2018

This study aims to obtain a description of the concept of local culinary-based tourism typical of Betawi, especially Pletok Beer. As a tourism product, a series of strategies and promotions should be prepared so that traditional drinks made from healthy spice extracts are worthy of being ambassadors representing Betawi culinary riches as well as having consistent standards of taste and optimal organoleptic quality. In addition, it is also designed to make factual and accurate description and description of historical facts related to Pletok Beer as one of Betawi local wisdom. The selection of Pletok Beer producers was conducted in 5 administrative areas, namely East Jakarta, South Jakarta, West Jakarta, Central Jakarta and North Jakarta.Jakarta is a city that has many functions and roles. Status as a modern city with a massive wave of development invasion also played a role to wipe out the existence of ethnic Betawi, the native inhabitants of Jakarta who deservedly welcome the presence of the immigrants. As one of the tourist destinations in Indonesia, quite a lot of Jakarta's local culture can be developed and promoted, including culinary riches. There are a line of delicious and unique dishes that are very potent Betawi so the appeal of the culinary tourist, either because of taste, health benefits, or the value of philosophy and history that accompany it. Unfortunately until now the Betawi culinary wealth has not become a reason for tourists to come to Jakarta.The results showed that Pletok Beer as a part of Betawi culinary wealth got support and positive appreciation if presented as welcome drink. Making Concentrate Beer Pletok be one way that can facilitate the storage and presentation so that more practical and efficient. Preparation of concentrate with concentration of 1/4 times and boiling time for 60 minutes in the research scale (1/2 recipe), proven to produce Pletok Beer Concentrate with taste and aroma quality that is not different from fresh Pletok beer without concentration.
STUDY RESPON INVESTOR TERHADAP OPINI GOING CONCERN
Authors: Prasetyo Aji
Published: May 2018

This research aims to analyze the response of investors to the going concern opinion on issuers listed on the Indonesia Stock Exchange.The population used in this research are all companies listed on the Indonesia Stock Exchange (IDX) in 2012-2013 so that the number of samples (n) = 106. Determination of sample do with purposive sampling method, samples are selected using criteria specified.Samples of data are collected using literature study and documentation. The data collected will be analyzed with descriptive statistical analysis, Different test and classical assumption. Descriptive statistical analysis was conducted to determine the dispersion and distribution of data. Different test is used to test the differences between the two variables are then used to test the research hypotheses. While the classical assumption test was conducted to test the feasibility of multiple linear regression models were then used to test the research hypotheses.In this research found evidence that there is no difference between the abnormal returns before going concern opinion issued by after receiving going concern opinion, there is no difference between the abnormal return issuers obtain going concern opinion with which to obtain an unqualified opinion and no significant influence going concern opinion to the cumulative abnormal return.
Türkiye’nin Kuzeyinde Karadeniz Kıyısı Boyunca Dağılış Gösteren Balarılarının Morfometrik Analizi
Authors: ÇAKMAK İbrahim
Published: May 2018

Bu

çalışmanın amacı, Türkiye’nin kuzeyindeki farklı bölgelerde, yaklaşık olarak

Karadeniz Bölgesi’nden Trakya’ya devam eden bir kara şeridinde yayılış gösteren

balarısı populasyonlarını ayırt etmektir. Populasyonlar arasındaki morfometrik

varyasyonu belirlemek için toplam 58 koloni 34 morfomertik karakter

kullanılarak standart morfometrik ölçümlere dayalı olarak istatistiksel

analizlerde değerlendirilmiştir. Ayrışım fonksiyon analizi (DFA), iklim ve ekolojik

özellikleri farklılık gösteren coğrafik bölgelerdeki belirsiz 6 populasyon

grubu arasında yüksek doğru sınıflandırma yüzdeleri vermiştir. Özellikle,

sonuçlar örnekleme alanının Doğu ucundan (Gürcistan sınırındaki) Batı ucunakadar

(Bulgaristan sınırındaki) kademeli bir karakter kayması göstermiştir. Yakın

alttürlerin ilişkilerini araştırmak için Almanya-Oberursel’deki Morfometrik Arı

Veri Bankası’ndan elde edilen referans örneklerini analizlere dahil ettik. Bu

kombine edilmiş DFA, Trakya bölgesine uzanan Türkiye'nin kuzey kesimindeA.

m. anatoliaca’nın baskın alttür

olduğunu doğrulamıştır. A.m.caucasicabazı Doğu Karadeniz lokasyonlarında

yaygındır, fakat bu alttürün bölünmesi, ayrıca batıya doğru Kuzey Trakya'ya

kadar dağınık halde bulunması arıcı faaliyetlerinin etkisine işaret etmektedir.

Trakya’nın güneyindeki arılar A. m. anatoliaca iken Trakya’nın kuzeyinde

bulunanlar karışık olsa da A. m. carnica ile yakın ilişki

göstermektedir.
KESTANE BALININ ANTİBAKTERİYELVE ANTİFUNGAL ETKİNLİĞİNİN İNCELENMESİ
Authors: BORUM A.Ebru
Published: May 2018

Balın

insan beslenmesindeki faydalarının yanı sıra, hastalıklardan koruyucu ve

iyileştirici etkileri de bulunmaktadır. Bal eski devirlerden beri günümüzde de

olmak üzere tıp alanında antibakteriyel etkisi yönüyle kullanılmaktadır. Yapılan çok sayıda çalışma, birçok bakterinin bala

değişik düzeylerde duyarlı olduğunu bildirilmiştir. Bazı araştırmalar, balın

%1.8-%10.8 MIC değerleri arasında birçok patojen etkene karşı etkili bir

antibakteriyel potansiyeli olduğunu göstermektedir. Balların antimikrobiyal etkisi bitki kaynaklarının farklılığına bağlı

olarak değişkenlik gösterir.

Bu çalışmada Bursa’nın farklı bölgelerindeki arıcılardan elde edilen 34 adet bal

örneğinin %100, %50 ve %25’lik konsantrasyonlarının 3 bakteri ve 1 maya

üzerindeki antimikrobiyal etkileri incelenmiştir.

Farklı

kaynaklardan elde edilen 34 bal örneğinin %100, %50, % 25 konsantrasyonlarınınStaphylococcus

aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Escherichia

coli (ATCC 25922), Candida albicans (ATCC 90028) üzerine

antibakteriyel etkinliği Agar difüzyon metodu ile test edilmiştir.

Antibakteriyel etkinlik analizlerinde 34 balın %100’lük konsantrasyonları, iki

bal örneği hariç, Staphylococcus aureus (ATCC 25923) ve Enterococcus

faecalis (ATCC 29212) üzerinde antibakteriyel etki göstermiştir. Bal

konsantrasyonu %50’ve % 25’e düştüğünde her iki bakteri üzerinde inhibisyon

oluşturan bal sayısı ve zon çapları azalmıştır.
ÜRÜNLÜ (KİTE)’DE EV DUVARLARI İÇİNDE VE BAHÇE DUVARLARI İÇİNDE YER ALAN ARILIKLARIN TESPİTİ İÇİN ÖN ARAŞTIRMA ÇALIŞMASI
Authors: GÜMGÜM Güven
Published: May 2018

iliği yapmak üzere yerleştirilmiş olan ve kovan

görevi gören nişler bulunmaktadır. Kerpiçten yapılmış ve kil ile sıvanmış olan

bu evler ile duvarlarda gömülü bulunan kovanlar bugün kullanılmamakta olup

evler günümüzde terkedilmiş durumdadırlar. Bahsi geçen nişler, kullanıldıkları

dönemde muhtemelen bir ahşap kapak ile kapatılmaktaydı ve aynı zamanda arıların

giriş-çıkışı için kapak üzerinde delikler bırakılmıştı. Ürünlü/Kite'deki

arılıklar geçmişteki bir geleneğin devamı olabilir. Roma döneminden günümüze

kadar gelebilen antik metinlerde yer alan, villa duvarına bal üretimi amaçlı

kovan yerleştirilmesi durumu; Ürünlü/Kite’de karşımıza çıkan kovanlar ve

arılıklar ile benzerlikler taşımakta olup bu arılıkların eşine dünyada çok

fazla rastlanmamaktadır. Ancak, İngiltere'de geç ortaçağda villa duvarlarının

içinde arılıkların bulunması, mevcut bulguları karşılaştırma açısından

önemlidir.