bluuebunny/crossref_metadata_2025 huggingface dataset:
Enabling Intelligent Omni-Surfaces in the Polarization Domain: Principles, Implementation and Applications
Authors: Palomares-Caballero Ángel , Molero Jiménez Carlos , Ghadi Farshad Rostami , López-Martínez F. Javier , Padilla Pablo , Morales-Jimenez David , Valenzuela-Valdés Juan
Published: April 2023

Wireless communications based on reconfigurable intelligent surfaces (RIS) have upsurged as a key research topic in the communication-theoretic arena. Recently, the RIS concept has evolved into the so-called simultaneously transmitting and reflecting intelligent omni-surfaces (STAR-IOS, or simply IOS), which extend the RIS functionality by incorporating transmission (in addition to reflection) capabilities. To realize STAR-IOS, full and independent reconfiguration capabilities for both reflected and transmitted waves are crucially required.

However, such full independent reconfiguration has thus far been hurdled by the intimate coupling between the transmission and reflection behaviour of the IOS elements. To overcome this challenge and realize the full potential of reconfigurable IOS-aided systems, we here advocate for the use of the polarization domain in the design and operation of STAR-IOS. Thanks to the polarization-dependent features of IOS elements, fully independent (reconfigurable) transmission and reflection modes can be delivered, thus bringing key performance improvements and opportunities for new communication scenarios. We here discuss the principles, benefits, and potential implementations of the proposed polarization-aided IOS, along with some key opportunities and associated challenges. 

[Comment: This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible]
Online Motion Planning for Safe Human-Robot Cooperation using B-Splines and Hidden Markov Models
Authors: Braglia Giovanni , Tagliavini Matteo , Pini Fabio , Biagiotti Luigi
Published: April 2023

When humans and robots work together, ensuring safe cooperation must be a priority. This research aims to develop a novel real-time planning algorithm that can handle unpredictable human movements by both slowing down task execution and modifying the robot's path based on the proximity of the human operator. To achieve this, an efficient method for updating the robot's motion is developed using a two-fold control approach that combines B-Splines and Hidden Markov Models. This allows the algorithm to adapt to a changing environment and avoid collisions. The proposed framework is thus validated using the Franka Emika Panda robot in a simple start-goal task. Our algorithm successfully avoids collision with the moving hand of an operator monitored by a fixed camera.
Sub-transfer Learning in Human Activity Recognition: Boosting the Outlier User Accuracy
Authors: Kanjilal Ria , Kucuk Muhammed F. , Uysal Ismail
Published: April 2023

In this human activity recognition dataset, there are a total of 53 participants, consisting of 33 adults and 20 youths. In a laboratory experiment, individuals were given a set of synchronized sensors that were attached to their wrist and ankle using customized Velcro bands. These sensors, which were called Triaxial Wocket accelerometers, were lightweight, small, and thin. While wearing these sensors, the participants performed everyday tasks, and the raw acceleration data was collected at a rate of 90 Hz and transmitted wirelessly to a smartphone via Bluetooth.
Frequency Range Enhancement in Differential Ring VCO while Maintaining Phase Noise Performance
Authors: SINGH MAYANK KUMAR , Singh Puneet , Kadayinti Naveen , Das Devarshi , Sakare Mahendra
Published: April 2023

This paper presents a differential delay cell-based ring voltage-controlled oscillator (RVCO). The proposed RVCO (PRVCO) introduces auxiliary charging and discharging paths in conventional ring VCO (CRVCO) that enhance the maximum operating frequency and frequency range. Adding auxiliary paths does not increase the maximum current in PRVCO within different time instants in one period compared to other available RVCOs. Thus, it maintains the phase noise performance. The post-layout simulations of the four-stage PRVCO were performed in 65nm CMOS technology with 1V supply voltage. The maximum operating frequency of the four-stage CRVCO, and PRVCO, are 585MHz and 3.2 GHz, respectively. The PRVCO improves the maximum operating frequency significantly compared to CRVCO. The PRVCO has a linear tuning range from 1.8 GHz to 3.2 GHz, which is 78% better than the CRVCO. The phase noise of the PRVCO is -103.8 dBc/Hz at an offset frequency of 1 MHz. The figure of merit (FoM) is improved by 11 dB compared to CRVCO in the same technology node of 65nm CMOS.
Spinor Representations of Positional Adapted Frame in the Euclidean 3-Space
Authors: İşbilir Zehra , Özen Kahraman Esen , Güner Mehmet
Published: April 2023

The main goal of this study is to bring together the spinors, which have a major place in several disciplines from mathematics to physics, and Positional Adapted Frame (PAF) which is a new type frame that attracts the attention of many researchers. In accordance with this purpose, we introduce the spinor representations for the trajectories endowed with PAF in the Euclidean 3-space $\mathbb{E}^3$, and construct the spinor equations of PAF vectors. Then, we find the relations between spinor representations of PAF and Serret-Frenet frame. Also we give some results and present some geometric interpretations with respect to this relationship. Moreover, we present an illustrative numerical example in order to support the given theorems and results.
Efek Susu Sinbiotik terhadap Struktur Mukosa Duodenum Mencit yang Diinduksi Minyak Trans Dosis Tinggi: Penelitian Hewan Coba
Authors: Supiyani Atin , Agussetiandari Indah , Handayani Tri , Sukmawati Dalia
Published: April 2023

Susu sinbiotik merupakan susu fermentasi probiotik yang dikombinasikan dengan prebiotik. Minyak trans merupakan minyak/lemak dengan struktur trans. Minyak trans yang dikonsumsi secara berlebih dan terus menerus dapat berdampak pada sistem pencernaan. Penelitian ini bertujuan mengetahui pengaruh susu sinbiotik (SS) mengandung tepung pisang tanduk (TP) terhadap struktur mukosa duodenum mencit yang diinduksi minyak trans (MT). Sebanyak 30 ekor mencit jantan strain DDY usia 2 bulan dibagi menjadi 6 kelompok yaitu MT; MT+simvastatin dosis 0,4 mg/20grBB; MT+SS; MT+SS(1%TP); MT+SS(3%TP); dan MT+SS(5%TP). Minyak trans dosis 200mg/20grBB diberikan pada hari 1-14. Susu sinbiotik dosis 200mg/20grBB diberikan pada hari 15-28. Hari ke-29 semua mencit diterminasi secara dekapitasi servikal dan organ duodenum diambil untuk dibuat preparat histologis. Morfologi mukosa duodenum dianalisis secara deskriptif. Secara morfologi duodenum ditemukan erosi vili dan deskuamasi epitel mukosa. Tingkat erosi dan deskuamasi epitel mukosa duodenum dari tinggi-rendah berturut-turut yaitu kelompok MT, MT+Simvastatin dan MT+SS. Semakin tinggi persentase tepung pisang semakin menurunkan tingkat erosi vili dan deskuamasi epitel mukosa duodenum. Pada kelompok susu sinbiotik dengan 5% tepung pisang tidak ditemukan erosi vili dan deskuamasi epitel duodenum. Maka dapat disimpulkan bahwa susu sinbiotik memperbaiki morfologi mukosa duodenum dari erosi vili dan deskuamasi epitel yang diakibatkan oleh minyak trans.
Perancangan dan Implementasi Frontend Web untuk Sistem Pengaduan Masyarakat
Authors: Terttiaavini  , I Made Agus Oka Gunawan  , Kraugusteeliana  , Winarno Edy , Rony Sandra Yofa Zebua
Published: April 2023

Sistem pengaduan masyarakat berbasis web sangat penting bagi Polsek Banda Sakti dalam meningkatkan efisiensi dalam menerima dan menangani pengaduan masyarakat. Dengan mengembangkan sistem pengaduan masyarakat berbasis web, Polsek Banda Sakti dapat memberikan sarana yang mudah digunakan dan efisien bagi masyarakat untuk melaporkan masalah yang dihadapinya. Hal ini akan memudahkan masyarakat dalam melaporkan masalah yang dihadapi sehingga dapat ditangani dengan cepat dan tepat. Selain itu, sistem ini juga memberikan kesempatan bagi Polsek Banda Sakti untuk mengaplikasikan ilmu dan keterampilan yang telah didapat dalam bidang pemrograman web dan pengembangan sistem. Dengan mengaplikasikan ilmu dan keterampilan tersebut, Polsek Banda Sakti dapat memberikan kontribusi nyata dalam pengembangan sistem pengaduan masyarakat. Sistem pengaduan masyarakat berbasis web ini dapat digunakan oleh masyarakat di wilayah Banda Sakti untuk melaporkan masalah yang dihadapi. Masyarakat dapat mengirimkan laporan dengan mengisi form yang tersedia di website. Setelah masyarakat mengirimkan laporan, laporan tersebut akan diterima oleh Polsek Banda Sakti dan ditindaklanjuti sesuai dengan prosedur yang berlaku. Sistem ini juga dilengkapi dengan fitur untuk melacak status laporan yang telah diterima oleh Polsek Banda Sakti. Website ini di rancang dan di desain dengan beberapa tool pemograman diantara nya dengan menggunakan framework laravel, boostrap dan lain-lain. Framework laravel digunakan untuk pengembangan sistem yang cepat dan mudah, sedangkan bootstrap digunakan untuk membuat tampilan website yang responsive dan mudah dibaca oleh masyarakat. Website ini di desain dengan user friendly dan sesuai dengan kebutuhan masyarakat. Hasil dari sistem website ini adalah dapat digunakan dan di implementasikan di polsek banda sakti serta memudahkan masyarakat di wilayah banda sakti dalam melaporkan masalah yang dihadapi. Sistem ini juga akan membantu Polsek Banda Sakti dalam meningkatkan efisiensi dalam menerima dan menangani pengaduan masyarakat.
Sistem Informasi Laporan Jumlah Penduduk Berbasis Web Based Application
Authors: Sadikin Abdurrahman , Yoseph Bhae Benediktus , Nurlaela Lela , Kurniati Ike , Suryantoro Hari
Published: April 2023

Kemajuan dan perkembangan teknologi informasi serta komunikasi mutakhir yang semakin pesat dan tantangan globalisasi sekarang ini menyebabkan perubahan yang cukup mendasar dalam kehidupan berbangsa dan bernegara. Perubahan tersebut tidak hanya menyangkut bentuk jejaring dan pola hubungan sosial baru yang sangat cepat dan tebuka, tetapi juga kesadaran kolektif untuk menempatkan sumber data informasi sebagal modal utama di tengah kompetisi global. Perkembangan kemajuan Teknologi Informasi di Indonesia hampir berdampak kepada semua aspek yang ada di masyarakat termasuk lembaga pemerintahan. Dengan adanya hal tersebut, lembaga pemerintahan di Indonesia akan berusaha memberikan pelayanan yang terbaik dengan memanfaatkan teknologi informasi yang ada dalam rangka mendukung suatu proses yang berkaitan dengan pendataan sehingga memberikan informasi yang cepat dan tepat khususnya untuk memajukan suatu institusi. Sistem informasi data penduduk pada tingkat desa biasanya masih menggunakan sistem yang manual. Hal ini menimbulkan beberapa kendala yang cukup merepotkan, terutama pada ketidakvalidan dan ketidakcocokan data. Sering pula terjadi kendala pada saat pencarian informasi tentang penduduk baru, maupun penduduk yang pindah dari desa tersebut. Demikian pula halnya dengan penyediaan data, misalnya data pekerjaan, data pendidikan, dan data demografi penduduk yang sering tidak up to date. Berangkat dari kendala-kendala di atas, maka dibuatlah rancangan suatu system informasi kependudukan. Diharapkan sistem informasi pendataan penduduk pada tingkat desa ini akan sangat membantu instansi pemerintah dalam melakukan pendataan penduduk dalam ruang lingkup sebuah desa. Dimana sistem ini akan melakukan proses pendataan seiring dengan proses pengajuan surat-surat kependudukan oleh setiap penduduk yang datang ke kantor kepala desa. Dengan demikian data kependudukan dapat diperoleh dengan mudah tanpa harus melakukan pendataan secara langsung ke tempat penduduk tersebut tinggal. Sistem yang dibangun ini dirancang dengan alur dan rancangan antar muka yang sederhana, sehingga dapat dengan mudah digunakan di lingkungan desa, dalam hal ini mengambil contoh di Desa XYZ, Kecamatan A Kota B.
Evaluation of the Possibilities of Magnetic Resonance Imaging in Monitoring the Treatment of Locally Advanced Cervical Cancer
Authors: Laryukov A. V. , Laryukova E. K. , Zidikhanov D. I. , Shakirova E. J. , Kurtasanov R. Sh. , Mindubaev E. Y.
Published: April 2023

Background: Cervical cancer occupies one of theleading places in cancer incidence in women. Preservation of residual tumor in  patients with  cervical  cancer  after  completion of combined chemoradiotherapy is a prognostically unfavorable factor. Detection of an early tumor response to chemoradiation therapy is of great importance for choosing the optimal treatment tactics.

Purpose: To study  the  possibilities of MRI in assessing the  effectiveness of detecting an  early  tumor response in patients with locally advanced cervical cancer  after combined chemoradiotherapy.

Material and methods: The results of magnetic resonance imaging of the  pelvic organs, data  of laboratory, cytological and postoperative histological studies of 174 patients with locally advanced cervical  cancer were analyzed  and compared.

MRI of the pelvic organs was performed before  the start  of treatment to assess  the extent  of the process (primary study) and 6 weeks after the completion of combined chemoradiotherapy to assess the effectiveness of the treatment and detect residual tumor (control study).

Conclusion: Magnetic resonance imaging of the pelvic organs using a standard research protocol, including obtaining diffusion-weighted images and dynamic contrast studies, is a highly informative method for staging locally advanced cervical cancer  and assessing the tumor response to treatment.
Clinical Observation: Assessment of Factors Associated with the Refusal or Termination of Treatment in Patients with Breast Cancer
Authors: Kuznetsova A. I. , Pakhomova Ya. N. , Tsiring D. A. , Vazhenin A. V. , Ponomareva I. V. , Mironchenko M. N. , Demchuk M. A. , Gladkov Yu. O. , Novikova T. S.
Published: April 2023

The  study  analyzed  the  clinical  observation of the  psychological characteristics  of a woman  diagnosed with  breast cancer,  who refused  part  of the proposed therapy, and had no contraindications to start  special treatment.

Patient Yu.F., born in 1953, diagnosis: cancer  of the right  breast T1NxM0 ЭР(95 %), ПР(15 %), Her2neu(0), Ki67 (5 %), refused  for personal reasons from the surgical treatment proposed at the 1st stage  (a written refusal was taken), in connection with which  a course  of hormone therapy was prescribed, a course  of remote radiation therapy according to a radical program. When assessing the psychological profile of the patient, the data obtained demonstrate the presence of paradoxical hyperprotection in the patient who refused part of the treatment. Her psychological profile is similar to the psychological characteristics of women with breast cancer, whose course  of the disease ended  in death.  In a study conducted in 2021, data were obtained on women with  a negative outcome of the  disease (death), who were convinced of their  own luck and in the  ability  to control what was happening, used a wide range  of coping  strategies, were more resilient, are optimistic and had a pronounced internality in comparison with women  in whom the disease went into stable  remission.
Spatial Fractionation in Tumor Radiotherapy and Discussed Mechanisms of the Therapeutic Window Extension
Authors: Wainson A. A. , Solovieva E. V.
Published: April 2023

Irradiation of the  tumor through the  ridge  filters  in order  to reduce  the  damage of the  normal tissues while maintaining the same damage to the neoplastic tissue  as with uniform field is used for many decades. In recent years, a positive effect has been demonstrated using synchrotron radiation and beams of accelerated protons with radiation fields diminished to 25-100 micrometers with the same distances between them.  Less skin  damage achieved while  maintaining the  required level of large  neoplasms eradication in the  case  of X-ray and gamma  irradiation through ridge  filters  can be partially explained by the features of the physical distribution of the dose over the depth of the irradiated tissue,  namely, the “merging” of fields at depth. But the  good  results from  the  use of the  ‘hills and  valleys’ in radiation fields  created by the  modern radiation sources  have attracted attention to radiobiological issues for explaining the principal differences in reaction to  spatial fractionation of the  absorbed dose  between tumor and  normal tissues. We  are  talking about the  role  of the  so-called ‘communal effect/bystander effect’, the  effect  of radiation on the  immunological processes, the  differences in damage and  restoration of the  microvasculature in normal and  tumor tissue, etc. Although there  is the lot of publications concerning experimental studies of the effectiveness of ‘spatial dose fractionation’, as well as those  considering radiobiological mechanisms of the  observed expansion of the ‘therapeutic interval’, there  is still no clarity in this issue. The purpose of this review is to systematize the available data on the clinical  and experimental confirmation of the effectiveness of ‘spatial fractionation’ and the  various  explanations of its  advantages over conventional, uniform dose  distribution. Special  attention is paid  to the  issues  of combination of spatial fractionation with  superhigh dose rate  irradiation (FLASH-radiotherapy) on the  new  radiation facilities, including proton accelerators, which  are  now  in use in this country.
Development of a Village Youth Entrepreneurship Model to Increase the Income of Wetland Village Communities
Authors: Anisah Hastin Umi , Isnawati  , Rifqi Novriyandana  , Nor Hikmah
Published: April 2023

The low competitiveness of human resources is highly correlated with the low potential and ability of the people's economy, which leads to higher poverty rates. Intervention in the economic capacity of the community needs to be carried out in order to prevent the negative effects of the lack of quality human resources. Entrepreneurship is a very important aspect to be developed in society as a form of economic intervention. This study aimed to develop a village youth entrepreneurship model to increase the income of wetland villages. This study is an observational study in Beranggas Timur Village, Alalak District, Barito Kuala Regency, South Kalimantan Province, Indonesia. Data analysis was carried out with PLS-SEM facilitated by SmartPLS 3. Creativity has no significant effect on entrepreneurial intention; Imagination has no significant effect on entrepreneurial intention; and personality has a significant effect on entrepreneurial intention.
Cross Sectional Study on Socio Demographic and Clinical Profile on Acute Abdomen in a Tertiary Care Hospital Hyderabad, Telangana
Authors: A Manmadha Kishan  , K Srinivasulu  , I V R Raghunath  , Mustafa Firasath  , Pantangi S. D. Kashyap Sharma  , Nikhitha Puvvala
Published: April 2023

A cross sectional study on socio demographic and clinical profile of acute abdomen was conducted in a tertiary care teaching hospital in Suraram, Hyderabad, Telangana. It was retrospective and record based study, 170 in-patient case sheets from the department of General surgery admitted in emergency with acute abdomen from1st July 2021 to 30st June 2022 were collected from Medical record department of Hospital. Socio demographic and clinical details were collected from the case sheets in to a pre structured data sheet and the data was analyzed by SPSS (version 21.0) software.Four most common causes of acute abdomen found in our study are acute appendicitis accounting 30% of total number of admissions, followed by acute cholecystitis with 21.2%, acid peptic diseases with 18.23% and renal calculi contributed fourth common cause of acute abdomen accounting 12.4%. Acute appendicitis was the leading cause in males whereas acute cholecystitis was the leading cause in females. Majority of cases 74.75% were treated conservatively and 25.35% cases were treated with surgery. 85.9% of cases were treated without any complications. Mortality was very negligible due to referral to higher centers. Similar results were observed in studies conducted in India and abroad.
A Study of Postmortem Findings of Asphxial Deaths Due to Hanging in a Semi Urban Region of Karnataka
Authors: Gopal B.K  , Subin B. George  , Roopak S.N  , Viswakanth B
Published: April 2023

Hanging, a method of deliberate & intentional self-harm amounts for a major proportion of autopsies whichmedicolegal experts encounter in their clinical tenure at various hospitals pan India. A retrospective study wasconducted in the Department of Forensic Medicine and Toxicology, Kanachur Institute of Medical Sciences,Mangalore from Jan 2016 to June 2022, with an objective to study the post mortem findings in autopsy casesof hanging. Out of 306 autopsies, 14.38 % cases were that of hanging with a female to male ratio being 3:1.Most cases were atypical (81.81%,36) and partial hanging (72.72%, 32) with the ligature mark situated abovethe thyroid cartilage. 86.36 % of cases (38) had dried salivary stain at the angle of mouth and one case showedinvoluntary discharge. The incidence of fracture of hyoid bone and thyroid cartilage not observed in any cases
Analytical Study of Suicidal Deaths in Female Reproductive Age Groups, Based on Autopsies Conducted in GGH, Mortuary
Authors: M. Subba Rao  , Jaffar Hussain A. P  , P. Ashok Kumar  , R. Ram Kishore  , R. Balamanigandan
Published: April 2023

Suicidal death is nothing but ending one’s own life, which is the most daunting human tragedies and a seriouspublic health problem. As for NCRB the suicide rate has increased from 6.2% (2020) to 7.2% (2021).This study takes100 cases retrospectively for the duration of 6 months. All suicidal deaths postmortem examinations are donein the reproductive age group females from April 2022 to September 2022. Those deaths occurred on the spot,or in the GGH Guntur, while undergoing treatment. The distribution of cases based on age, geographical area,marital status, educational status, place of occurrence, history of previous attempt of suicide, hormonal status infemale, case of death and motive behind the suicide. Majority of cases belong to age group 19-29 years and 58%of urban population committed suicide with common motive behind the suicide is failure in exam. Preferredmethod for death is ingestion of poison which is seen in 46% of cases. Victims with changes in hormonal statuslike in menstruation are considerable in number. Family history of committing suicides or history of suicides inthe neighbors have provocated some people. Counselling of such identified group of people at various levelswill help the needy victims and decrease the suicide incidence.
Diatom Examination From Ganga River at Vindhyachal - A Forensic Approach
Authors: Priyanka Kumari  , Munish Kumar Mishra  , Lav Kesharwani
Published: April 2023

Diatoms are unicellular, photosynthetic (autotrophic), eukaryotic organisms often classified as among the algae.They are scientifically known as Bacillariophyceae. Diatoms study can be used in medico-legal purpose to solvethe cases of unclaimed drowned or dumped bodies. The detection of diatoms in the organscan contribute toa diagnosis of death by drowning, a process referred to as the ‘diatom test’.This study was conducted in thedepartment of Forensic Science, SHUATS, Prayagrajwhich included the extraction and identification of diatomsfrom the collected water samples from three different sites of Ganga River in Vindhyachal. The acid-digestionmethod was used for diatom extraction. 27 samples were collected (3 from each site) in the month of January,February, March 2022 from 3 different ghats of Vindhyachali.e Babu Ghat, Pakka Ghat, Diwan Ghat. Samples weretaken from surface, 1 feet and 2 feet deep inside river. After examination and analysis total 18 genera of diatomswere found. The identified diatoms were of greatecological importanceand plays an important role in criminalinvestigations related to pre-mortem or ante-mortem drowning deaths in Ganga river at Vindhyachal,district ofU.P,India
ESTIMATION OF LOST PROFIT OF IRRATIONAL USE OF SUBSOIL USE
Authors: Кузина Елизавета Сергеевна
Published: April 2023

В статье рассмотрена оценка упущенной выгоды и ущерба, который нанесен недрам в результате их нерационального использования, он основан на нормативных правовых актах Российской Федерации, включающих перечень прав и обязанностей недропользователей, основные требования по рациональному использованию и охране недр, порядок установления факта правонарушения в области недропользования, ответственность за нарушение законодательства и возмещение убытков, а также порядок компенсации нанесенного ущерба от нерационального недропользования. Использование подхода позволит значительно повысить эколого-экономическую эффективность недропользования.

The article considers the assessment of lost profits and damage caused to subsoil as a result of their irrational use, it is based on the regulatory legal acts of the Russian Federation, including a list of rights and obligations of subsoil users, basic requirements for the rational use and protection of subsoil, the procedure for establishing the fact of an offense in the field of subsoil use, liability for violation of the law and compensation for losses, as well as the procedure for compensation for damage caused by irrational subsoil use. Using the approach will significantly improve the environmental and economic efficiency of subsoil use.
DIFFICULTIES OF TEXT UNDERSTANDING BY STUDENTS WITH IMPAIRED HEARING OF JUNIOR SCHOOL AGE
Authors: Дымич Яна Вагановна , Труханова Юлия Александровна
Published: April 2023

В статье рассматриваются особенности понимания текста младшими школьниками с нарушениями слуха.

The article discusses the features of understanding the text by younger students with hearing impairments.
ROLE OF CYTOKINES AND CYTOCHROMES P450 IN METABOLISM OF ANTIVIRAL DRUGS FROM COVID-19
Authors: Баранова Надежда Ивановна , Ащина Людмила Андреевна , Болгова Александра Игоревна
Published: April 2023

Представлен обзор данных о возможном влиянии фармакогенетических маркеров на эффективность и безопасность этиотропной терапии COVID-19. Рассматриваются клинические исследования ремдесивира, фавипиравира, молнупиравира. Описываются потенциальные фармакогенетические маркеры цитокинов, влияющие на гены семейства цитохромов P450.

A review of the data on the possible influence of pharmacogenetic markers on the efficacy and safety of COVID-19 etiotropic therapy is presented. Clinical trials of remdesivir, favipiravir, and molnupiravir are reviewed. Potential pharmacogenetic markers of cytokines affecting cytochrome P450 family genes are described.
VEGETABLE DRINKS FROM OATS. THEIR ORGANOLEPTIC PROFILE AND PHYSICO-CHEMICAL CHARACTERISTICS
Authors: Синельникова Марина Юрьевна , Матвеева Дарья Юрьевна
Published: April 2023

Использовалось четыре типа исходного сырья с разными характеристиками и способами его подготовки. Выявлено сырье с наилучшими характеристиками для использования в технологическом процессе. С целью подтверждения качества напитков были определены показатели не только по ГОСТ, но и дополнительные показатели такие как: β -глюкан, полифенолы, аминокислоты, белки. β-глюкан известен своим свойством стабилизации уровня сахара в крови и холестерина в организме, что подтверждает его важность для определения в растительных напитках и увеличивает их функциональность. Содержание и состав фенольных компонентов в зерне зависит от его сорта и условий выращивания. Существует обратная зависимость между содержанием белка и полифенолами: чем выше содержание белка, тем ниже содержание полифенолов. В вызревшем овсе большую часть общего азота составляют белковые вещества, небелковый азот присутствует в незначительном количестве и представлен в основном аминокислотами и амидами. В рамках данной работы проведен анализ методов исследуемых веществ, а также их адаптация для применения к данному виду продукции.

Four types of raw materials were used with different characteristics and methods of their preparation. Raw materials with the best characteristics for use in the technological process have been identified. In order to confirm the quality of drinks, indicators were determined not only according to GOST, but also additional indicators such as: β-glucan, polyphenols, amino acids, proteins. β-glucan is known for its ability to stabilize blood sugar and cholesterol levels in the body, which confirms its importance for detection in plant-based drinks and increases their functionality. The content and composition of phenolic components in grain depends on its variety and growing conditions. There is an inverse relationship between protein content and polyphenols: the higher the protein content, the lower the polyphenol content. In ripened oats, protein substances make up an increasing part of the total nitrogen, non-protein nitrogen is present in an insignificant amount and is represented mainly by amino acids and amides. Within the framework of this work, an analysis of the methods of the studied substances was carried out, as well as their adaptation for application to this type of product.
EFFECTIVE EMPLOYMENT CONTRACT WITH A TEACHER: PAST AND PRESENT
Authors: Хабиева Елена Викторовна
Published: April 2023

Эффективный трудовой договор с преподавателями средних профессиональных образовательных организаций - способ практической реализации гарантий работнику по достойной оплате труда, складывающейся из базовой части оплаты труда (тарифная ставка, оклад), компенсационных и стимулирующих выплат, а также выплат социального характера.

An effective employment contract with teachers of secondary vocational educational organizations is a way of practical implementation of guarantees to the employee for decent wages, consisting of the basic part of wages (wage rate, salary), compensation and incentive payments, as well as payments of social character.
Análisis de la influencia de la pandemia por el virus SARS-CoV-2 sobre la tasa de bacteriemia en catéteres venosos tunelizados en una unidad de hemodiálisis
Authors: Gimeno-Hernán Verónica , Herrero-Calvo José Antonio , Faraldo-Cabaña Araceli , Zaragoza-García Ignacio , Del Pino-Jurado María del Rosario , Ortuño-Soriano Ismael
Published: April 2023

Antecedentes: La infección relacionada con catéter venoso central (CVC) está asociada a una elevada morbimortalidad y se ha relacionado con la bacteriemia asociada a CVC, disfunciones de catéter, la manipulación y las medidas higiénicas tomadas durante la misma.
Objetivo: El objetivo del presente estudio fue comparar la tasa de bacteriemia entre los años 2019 y 2020, primer año de pandemia por el virus SARS-CoV-2, en una unidad de hemodiálisis de un hospital de la Comunidad Autónoma de Madrid.
Material y Método: Se ha llevado a cabo un estudio observacional retrospectivo transversal en el que se compararon datos relativos a la manipulación y al funcionamiento del catéter, y tasa de bacteriemias relacionadas con el catéter entre los años 2019 y 2020 a través de la base de datos de la unidad.
Resultados: En 2019 se incluyeron 35 pacientes, que presentaron una tasa de bacteriemia de 1,42/1000 días de catéter y 29 pacientes en 2020, con una tasa de bacteriemia de 1,82/1000 días de catéter, no encontrándose diferencias significativas (p=0,54), no encontrando un riesgo de bacteriemia incrementado o disminuido durante el primer año de pandemia producida por el virus SARS-CoV-2.
Conclusiones: Como principal conclusión de este estudio, podemos afirmar que no se ha evidenciado que la llegada de la pandemia producida por la enfermedad del coronavirus y las medidas adoptadas frente al virus SARS-CoV-2, tanto organizacionales como de prevención, sean un factor de riesgo o protección respecto a la tasa de bacteriemia, probablemente debido al bajo número de eventos encontrados.
COVID-19 Pandemisi ve E-Ticaret Kullanımı: Kuşaklararası Farklılıklar
Authors: ALKAN Ömer , BAYHAN Yağız Can
Published: April 2023

Covid-19 pandemisi ile birlikte e-ticaret daha önce olmadığı kadar önem kazanmıştır. Mağazaların kapalı olması ve sosyal hayatın kesintiye uğramasıyla, daha önce hiç e-ticareti deneyimlememiş insanlar e-ticarete yönelmeye başlamıştır. Bu çalışmanın amacı; covid-19 döneminde Türkiye’de kuşaklararası farklılıklar dikkate alınarak e-ticaret kullanıcılarının genel profilini belirlemek ve bireylerin e-ticaret eğilimlerini etkileyen sosyo-demografik faktörleri tespit etmektir. Bu amaç doğrultusunda 2021 yılında TUİK tarafından yapılan Hanehalkı Bilişim Teknolojileri Kullanım Araştırması verileri kullanılmış olup (n=30530) bireylerin e-ticaret eğilimleri ikili lojistik regresyon yöntemiyle incelenmiştir. Elde edilen bulgulara göre Z, Y ve X kuşaklarında kadınların, bebek patlaması kuşağında ise erkeklerin e-ticarete katılma olasılıklarının daha fazla olduğu tespit edilmiştir. Tüm kuşaklarda üniversite mezunu bireylerin internet alışverişi yapma olasılıklarının daha fazla olduğu tespit edilmiştir. Aile büyüklüğünün az olması ve aylık gelirin yüksek olması, e-ticarete katılma olasılığını artırmaktadır. Ayrıca, nispeten az gelişmiş bölgeler olan Kuzeydoğu Anadolu ve Ortadoğu Anadolu bölgelerine kıyasla gelişmiş bölgeler olan İstanbul, Batı Marmara, Doğu Marmara, Ege ve Akdeniz bölgelerinde e-ticaret daha çok tercih edilmektedir. Bununla birlikte iş durumu, cep telefonu sahipliği durumu, dizüstü bilgisayar sahipliği durumu, masaüstü bilgisayar sahipliği durumu, tablet bilgisayar sahipliği durumu, e-devlet hizmetleri kullanımı durumu ve internet üzerinden finansal işlemler gerçekleştirme durumu değişkenlerinin e-ticaret üzerinde anlamlı faktörler olduğu tespit edilmiştir.
Armies of War Without Uniforms: Mercenaries and Private Military Companies in Russia’s Interventions in Syria and Ukraine
Authors: MAVRUK Çağla , GÖK Ali
Published: April 2023

In the struggle for influence and power between states, states tend to use mercenaries and PMCs due to reasons such as the economic cost of the regular army, the negative reactions to be received from many actors in an official intervention in the target state, the sanctions of international law and the indignation caused by a possible loss of official soldiers, especially in the society. The history of mercenaries dates back to ancient times. However, they were used extensively in conflicts in many regions after the Cold War. The changing perception of security is the main reason for the resurgence of mercenary activities. Factors at the center of the changing perception of security are the end of the Cold War and the emergence of a privatized military industry. Considering the interventions where mercenaries were deployed, Russia’s interventions in Ukraine in 2014 and then in 2022 and in Syria in 2015 come into prominence. The overarching purpose of this research is to explain how these actors affect the character of the war by explaining the reasons for their use, duties and effects on the battlefield. The study concludes that Russia used mercenaries in Ukraine for secrecy and reasonable deniability and aimed to prevent the reaction of the world public opinion. On the other hand, Russia used mercenaries in Syria to prevent the reaction of the Russian public by hiding casualties and reflecting the operation as a successful operation without any casualties.
The Effect of Coronavirus on Undergraduate Students in the Gauteng Province of South Africa during 2020-2022: An Interdisciplinary Assessment
Authors: Nkuna Matimu Tsundzukani , Nkuna Vusimuzi Goodman
Published: April 2023

The coronavirus pandemic has affected almost every aspect of human life across the entire globe, including tertiary education. This interdisciplinary study explored how undergraduate students in tertiary institutions located in Gauteng Province of South Africa experienced and coped with the effects of the pandemic between the 2020 to 2022 academic years. The article used the Rites of Passage Concept to interpret how they transitioned from in-person learning to online learning, and from the latter to hybrid learning. It then used psychological concepts of self-efficacy, self-regulation and self-control to illustrate how they motivated themselves to continue pursuing their academic studies. To conduct this phenomenological study, the researchers used participatory observation and in-depth interviews to collect data over a three-year period. They then employed concepts from anthropology and psychology to interpret the students’ experience. While recognizing its limited scope, the researchers argued that the study was able to illustrate the symbiotic relationship between anthropology and psychology in social scientific research. It is their hope that the findings of this study contribute to existing scholarship in the field of humanities concerning stressors and coping strategies.

Keywords: Interdisciplinary Study, COVID-19, Concept of the Rites of Passage, Coping Strategies
Cosmological-model-independent Determination of Hubble Constant from Fast Radio Bursts and Hubble Parameter Measurements
Authors: Liu Yang , Yu Hongwei , Wu Puxun
Published: April 2023

We establish a cosmological-model-independent method to determine the Hubble constant H
0 from the localized fast radio bursts (FRBs) and the Hubble parameter measurements from cosmic chronometers and obtain a first such determination H
0 = 71 ± 3 km s−1 Mpc−1, with an uncertainty of 4%, from the eighteen localized FRBs and nineteen Hubble parameter measurements in the redshift range 0 < z ≤ 0.66. This value, which is independent of the cosmological model, is consistent with the results from the nearby Type Ia supernovae (SNe Ia) data calibrated by Cepheids and the Planck cosmic microwave background radiation observations at the 1σ and 2σ confidence level, respectively. Simulations show that the uncertainty of H
0 can be decreased to the level of that from the nearby SNe Ia when mock data from 500 localized FRBs with 50 Hubble parameter measurements in the redshift range of 0 < z ≤ 1 are used. Since localized FRBs are expected to be detected in large quantities, our method will be able to give a reliable and more precise determination of H
0 in the very near future, which will help us to figure out the possible origin of the Hubble constant disagreement.
The Behavior of Bp He-weak Stars in the Far UV—Paper III: HD 175362
Authors: Monier Richard
Published: April 2023

The analysis of twelve spectra of the Bp He-weak Si star HD 175362 recorded by the SWP camera on board the International Ultraviolet Explorer reveals variations of the far-ultraviolet spectral energy distribution over a time interval of several years. Variations are present shortwards of 1700 Å which can be partly attributed to variations of lines and continuum of Si ii. Other lines due to C ii, Si iii and Si iv also contribute to the opacity in this range too. The variations suggest that silicon and carbon are not distributed in a uniform manner over the surface.
The mitochondrial genome of the bioluminescent fish Malacosteus niger Ayres, 1848 (Stomiidae, Actinopterygii) is large and complex, and contains an inverted-repeat structure
Authors: Gastineau Romain , Otis Christian , Boyle Brian , Lemieux Claude , Turmel Monique , St-Cyr Jérôme , Koken Marcel
Published: April 2023

We determined the complete mitogenome sequence of the bioluminescent fish Malacosteus niger using long-read sequencing technologies. The 21,263 bp mitogenome features a complex structure with two copies of a 1198-bp inverted-repeat and a region of 2616-bp containing alternating copies of 16 and 26 bp repeat elements. Whole mitogenome phylogenies inferred from both nucleotide and amino-acid datasets place M. niger among Melanostomiinae. The need for additional complete mitogenome sequences from the subfamily Malacosteinae is discussed.
Silkmoth pupae: potential and less exploited alternative source of nutrients and natural antioxidants
Authors: Mokaya H.O. , Ndunda R.M. , Kegode T.M. , Koech S.J. , Tanga C.M. , Subramanian S. , Ngoka B.
Published: April 2023

Increasing global populations and decreasing sources of nutrients to feed them, has necessitated the drive for alternative and more sustainable sources of nutrients. Such alternatives should contribute to meet the demand for food and minimise negative effects on the environment. Edible insects, which have been traditionally part of human diets, stand out as the most probable and sustainable alternative. Silkmoth pupae, by-products of the sericulture sector are among the traditional foods consumed in Asia. In this study we determined the nutritional composition, phytochemical contents, and antioxidant activities of freeze-dried pupae from 2 domesticated and 3 wild silkmoth species. Our results showed that both Bombyx mori L. and Samia cynthia ricini Boisduval pupae had the highest amounts of proteins, 78.9 and 76.0 mg bovine serum albumin equivalents /g, respectively. Significantly high amounts of lipids (26.7%) were observed in B. mori pupae. Domesticated silkworm species recorded significantly high amounts of protein compared to the wild species. In addition, all silkmoth pupae had substantial amounts of phytochemicals that varied significantly between the studied species. We further demonstrated that all pupae samples exhibited antioxidant activities for both 50% methanolic and 100% hexane extracts, at very low concentrations of 2.5 and 30 mg/ml, respectively, with Anaphe panda pupae samples recording the highest activities. The multivariate analysis confirmed significant differences in the chemical composition of silkmoth pupae between species and type of diet they consume. Therefore, our findings suggest that the studied silkmoth pupae are rich alternative source of nutrients and natural antioxidants.
Pediatric and Adult Fracture Incidence: A Decreasing Trend With Increasing Hospital Admissions
Authors: Brazell Christopher J. , Carry Patrick M. , Holmes Kaley S. , Salton Reba L. , Hadley-Miller Nancy , Georgopoulos Gaia
Published: April 2023

Large-scale studies examining fracture trends and epidemiological data are lacking. The purpose of this study was to evaluate the incidence of fractures presenting to US emergency departments using the National Electronic Injury Surveillance System. A total of 7,109,078 pediatric and 13,592,548 adult patients presenting to US emergency departments with a fracture between 2008 and 2017 were analyzed for patterns. Fractures accounted for 13.9% of pediatric injuries and 15% of adult injuries. Among children, fracture incidence was highest in the group 10 to 14 years old and most frequently involved the forearm (19.0%). Fracture incidence was highest in adults 80 years and older and most frequently involved the lower trunk (16.2%). On average, the rate of pediatric fractures decreased by 2.34% per year (95% CI, 0.25% increase to 4.88% decrease;
P
=.0757). Among adults, fracture incidence increased 0.33% per year (95% CI, 2.34% decrease to 2.85% increase;
P
=.7892). This change was significantly different between the pediatric and adult populations (
P
=.0152). There was an increase in the annual proportion of adults with fractures who were admitted (odds ratio per 1-year increase, 1.05; 95% CI, 1.03–1.07;
P
<.0001). There was no change in the proportion of pediatric patients with fractures who were admitted (odds ratio, 1.02; 95% CI, 0.99–1.05;
P
=.0606). The incidence of fractures decreased in pediatric patients yet was relatively stable in adult patients. Conversely, the proportion of patients with fractures who were admitted increased, particularly among adults. These findings may suggest that less severe fractures are presenting elsewhere, falsely inflating the observed rise in admissions. [
Orthopedics
. 2023;46(6):e369–e375.]
Predictors of Adverse Events in the Surgical Treatment of Adult Distal Humerus Fractures
Authors: Movassaghi Kamran , Locker Philip , Kunze Kyle N. , Khoo Kendrick M. , Hoekzema Nathan
Published: April 2023

The purpose of this study was to identify surgical complications after distal humerus fracture fixation as well as correlations between these complications and patient variables. A total of 132 patients underwent open reduction and internal fixation of traumatic distal humerus fractures between October 2011 and June 2018. Included were adult patients who underwent surgical fixation and had more than 6 months of follow-up. Excluded were patients with inadequate radiographic imaging, less than 6 months of follow-up, and previous distal humerus surgery. Multivariate logistic regression models controlling for age and body mass index were used to determine preoperative factors predictive of postoperative complications. A total of 73 patients were included in this analysis. Surgical complications were reported for 17 patients. Reoperation was required for 13 patients. Open injury at presentation was predictive of delayed union. Predictors of subsequent elbow surgery included younger age, polytrauma, open fracture, and ulnar nerve injury at the time of injury. Radial nerve injury at the time of presentation was also a risk factor for postoperative radial nerve symptoms. Predictors of postoperative heterotopic ossification included older age. Thirty-one patients had an olecranon osteotomy during their open reduction and internal fixation and none went on to nonunion. There were 13 patients with ulnar nerve complications. Of these patients, 3 had undergone an ulnar nerve transposition. None of the other studied variables were predictors of complications, malunion, or nonunion at latest follow-up. Although open reduction and internal fixation is effective in treating distal humerus fractures, its complications cannot be overlooked. Open fractures are more likely to go on to delayed union. Ulnar nerve injury, open fracture, and polytrauma were predictive for reoperation. Older patients were less likely to have subsequent surgery but more likely to develop heterotopic ossification. By identifying at-risk patients, managing physicians can better prognosticate and counsel patients on their recovery. [
Orthopedics
. 2023;46(6):352–357.]
The Impact of Virtual Classrooms and Google Sites on Teaching Computer Skills Courses: Karak University College-Jordan
Authors: Allahawiah Sattam , Altarawneh Haroon , Almajaly Nashat
Published: April 2023

This study aimed to investigate the effect of both virtual classrooms and Google sites in teaching computer skills courses in Al- Karak College of Al-Balqa Applied University. The study used two different teaching strategies (WizIQ Virtual Classroom) and (Google Sites). The participants of the study were selected by a simple random sample. They were selected from the students of Al- Karak College of Al-Balqa Applied University who are signed up in a computer skills course which is a compulsory subject. The participants were chosen from different majors for the academic year of 2019-2020. The total number of student's are160. But 50 students (male and female) were collected randomly. They were divided into three main groups. The study showed a number of findings. Most importantly, the results of the group which was taught by (WizIQ Virtual) had better academic achievements than the control group in the post-test also, the group that was taught, according to Google, outperformed the control group Using (WizIQ Virtual) has facilitated their access to the needed information so, they did better. This study recommends instructors and teachers invest and use this strategy i.e., “WizIQ Virtual” in teaching this course. This may be due to various reasons: for example, it increases the academic achievements of the students. The study also recommends the Ministers of Higher Education and Scientific Research apply (Google sites) and (WizIQ Virtual) in teaching this course in all our Jordanian Universities.