bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPLEX ANALYSIS OF THE ROLE OF CYTOKINE GENE POLYMORPHISMS AS PROGNOSTIC FACTOR OF THE RISK OF PLASMA CELL MYELOMA IN PERSONS SUFFERED AFTER THE CHORNOBYL NPP ACCIDENT
Authors:   State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Minchenko Zh. M. , Dmytrenko O. O. ,   State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Liubarets T. F. ,   O. O. Bogomolets National Medical University, Silaev Yu. O. ,   State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Stroy D. O. ,   O. O. Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine, Balan V. V. ,   State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Shlyakhtychenko T. Yu. ,   State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine»
Published: December 2022

Objective: to provide a comparative characterization of the prevalence of polymorphic variants of cytokine genes in plasma cell myeloma (PCM) patients suffered after the Chornobyl disaster and patients who were in contact with ionizing radiation within the natural radiation background, based on comparison with population controls to determine their contribution as genetic markers of disease risk. Materials and methods. Molecular genetic studies of polymorphism of cytokine genes (TNF-α, TGF-β1, IL-6, IL-10, IFN-γ) and complex frequency analysis of occurrence in three-, four-, and five-locus combinations of their allelic variants as prognostic markers of the risks of plasma cell myeloma was carried out in 102 patients – 56 victims of the Chornobyl nuclear power plant accident and 46 patients irradiated within the limits of the natural radiation background, in comparison with the control group (364 practically healthy people, residents of the Central geno-geographical region of Ukraine). Results. The same probable increase in the prevalence of the TGF-β genotype codon10 T/T of the TGF-β1 gene was established in the groups of patients irradiated after the Chornobyl NPP accident and non-irradiated patients. In patients with plasma cell myeloma a protective effect for IL-10 -1082 A/G and an association with the risk of disease occurrence for IL-10 -1082 G/G were determined. Conclusion. Probable difference in the frequency of the TGF-β1 genotype codon10 T/T of the TGF-β1 gene in the observed groups relative to the control group provides grounds for considering this single-nucleotide polymorphism of the TGF-β1 gene as an immunogenetic factor of predisposition to the development of PCM independent of exogenous factors. The study of the contribution of multigene combinations of «gene-gene» interaction indicates their role in the mechanisms of plasma cell myeloma occurrence and confirms the presence of an additive interaction. Key words: plasma cell myeloma, cytokines TNF-α, TGF-β1, IL-6, IL-10, IFN-γ, ionizing radiation, Chornobyl NPP accident.
Epididimal manda spermasının dondurulmasında spermaya katılan farklı sulandırıcıların spermatolojik parametreler üzerine etkisinin in-vitro değerlendirilmesi
Authors: DEMİRCİ Emre , SELCUK Murat
Published: December 2022

Yapılan bu araştırmanın amacı, mezbahanelerden kesim sonrası alınan manda testislerinden elde edilen epididimal spermalarda çeşitli sperma sulandırıcıları kullanarak dondurmanın bazı spermatolojik parametreler üzerine etkisinin incelenmesidir. Mezbahanelerden kesim sonrası alınan 15 adet erkek Anadolu mandası (3 yaş ve üzeri) testislerinden elde edilen epididimal spermalara 6 farklı sperma sulandırıcısı (Tris, OptixCell®, BioXcell®, BullXcell®, AndroMed®, Steridly®) katılarak yapılan spermatolojik muayenelerle spermatozoonların motilitesi, ölü/canlı spermatozoon oranı, anormal spermatozoon oranı ve Hipo Osmotik Şişme Testi (HOST) oranları saptandı. Araştırmada taze sperma ile çözüm sonu sperma motilitesi, ölü spermatozoon oranı, HOST oranı, orta kısım, kuyruk ve toplam anormal spermatozoa oranları arasında önemli (p
Wound healing effects of bee venom on adipose tissue derived mesenchymal stem cells
Authors: ÖZGENÇ Özge , SEVİN Sedat
Published: December 2022

The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla province of Türkiye. Cell viability test was performed on mesenchymal stem cells exposed to various concentrations (40 ppm, 20 ppm, 10 ppm, 5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm and 0.312 ppm) of bee venom. And wound healing test was performed on cells treated with the doses (5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm) and imaged every two hours for 16 hours. According to the results of our study's cell proliferation assay and wound healing test, bee venom had no proliferative effect on mesenchymal stem cells within the defined dose range. The study's outcomes may be enhanced by investigating the effect of bee venom on mesenchymal stem cells in combination with other substances or by improving the bee venom's purification process. Even while we have a better understanding of the mechanisms of action of bee venom components, there are still a lot of unanswered questions on the subject. It is believed that figuring out how bee venom affects wound healing may be useful for advancing wound care in both veterinary and human medicine.
SCHOOL PREVENTION AGAINST SUICIDAL BEHAVIOUR ON THE BASIS OF DATA INCLUDED IN GOOD-BYE LETTERS OF MINOR SUICIDES
Authors: Urbanek Arkadiusz
Published: December 2022

This article tackles the issue of reconstructing the circumstances of suicides committed among adolescents aged 14,15 and 17, on the basis of analysis of good-bye letters and the discourse of life stories of individual cases. The presented research procedure focuses on capturing linguistic categories conveyed within the statements of young suicides’ good-bye letters. Abstracting adequate linguistic categories from the entire content has been combined with analysis of their meaningfulness and context in entire statement, hence enabling reconstruction of the interpretation applied by the young suicides while perceiving themselves and the reality around. The methodology implied model of hermeneutic analysis of statements with additional usage of categorizing affiliation method. Conclusions from the research are of practical value, contributing to the issues of early prevention under circumstances of suicidal behaviour, constituting relevant source of practical knowledge for teachers and tutors. The research into young suicide’s statements provides material which may in its practical dimension establish aspects crucial for school discussions facilitating expressions of own interpretation and judgments, as well as making teachers aware of various signals sent out by the pupils. The research results embrace linguistic categories expressed in letters, with presentation of their description and the context. Concurrently those constitute clear information about inadequate ways of interpreting the reality, additionally revealing number of similarities in communication patterns among the suicides. Key words: good-bye letter, prevention, pupil, suicide, teacher.
HUMANISATION OF NATURAL SCIENCE EDUCATION AS A PROBLEM
Authors: Lamanauskas Vincentas
Published: December 2022

The present humankind has to solve a number of serious problems. Under the threat of the ecology catastrophe, concern for physical and spiritual health care is felt. All our relations with nature turn out to be problematic. The establishment of a harmonious correlation between nature and society becomes an important task. We cannot exclusively rely on knowledge and mind in any activity as these are not overall dimensions. Enforcement of humanism, democracy and being a good citizen - these are common everyday issues in our schools today. The goal of the education reform is to make a school the place for creating a personality and not only the place to pump with knowledge.
Effect of Thermal Processing on Elimination of Antinutritional Factors in Irvingia smithii Almond
Authors: V.G. Gindo Mbaya  , P.E. Sumbu Zola  , E. Kimbemuken Thasur  , D. Mayele Kipoy
Published: December 2022

The objective of this work is to identify and eliminate antinutritional factors in the fruit kernel of Irvingia smithii (wild mango tree) from the KISANTU botanical garden (DRC) by thermal effect at different temperatures (T1: sun drying, T2: roasting in an oven at 130° C for 30 minutes, T3: boiling for 45 minutes) as a function of time. It appears from the results of our analyzes that the fruit kernels of Irvingia smithii contain antinutritional factors in low proportions: phytates (536.34mg/100g), oxalates (14.84mg/100g), nitrates (12.71mg/100g, 8), and nitrites (50.15mg/100g,). Saponins were not found in these almonds. Treatment of almonds by boiling for 45 minutes (T2 treatment) proved to be the best eliminator of antinutritional factors (60%) followed by treatment of almonds by roasting (T3) (43%), probably by the dissolution of antinutritional factors in medium aqueous (hydrolysis) and their evaporation by boiling which takes place during cooking. Wild mango (Irvingia smithii) levels of antinutrients are low enough to cause poisoning in their consumers; they have not yet been detected in human tissue or the urine of their consumers. We recommend that the roasting of the almond is done before cooking which is done by boiling, a process which will eliminate almost all the antinutritional factors.
Diagnosis of Autonomic Dysfunction Syndrome in Young Atheletes
Authors:   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Samoylov A.S. , Zholinskiy A.V. ,   2Federal scientific and clinical center for sports medicine and rehabilitation of the FMBA of Russia, Moscow, Rylova N.V. ,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Bolshakov I.V. ,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency
Published: December 2022

Purpose: A review of the most common and effective from the point of view of evidence-based medicine methods for diagnosing autonomic dysfunction syndrome in young athletes. Material and methods: The data of domestic and foreign literature on the diagnosis of autonomic dysfunction syndrome were analyzed. The search was carried out using electronic databases MEDLINE, Embase, Scopus, Web of Science, eLIBRARY and Google Academy for the period from 2017 to 2022. For the search, we used keywords and their combinations: “vegetative dysfunction syndrome”, “athletes”, “diagnostics”, “functional tests”. A total of 28 sources analyzed Results: The autonomic dysfunction syndrome (ADS) is characterized by a significant polymorphism of clinical manifestations and is characterized by functional disorders of the activity of the cardiovascular, endocrine and other systems of the body. Diagnosis of this condition is associated with great difficulties associated with the nonspecificity of symptoms, their bright emotional color and the absence of morphological changes in organs. The frequent manifestation of ADS in childhood and adolescence, the proven relationship of symptoms with exercise and mental stress, determines the importance of early and effective diagnosis of this syndrome in young athletes. The key research methods for suspected autonomic dysfunction syndrome include taking anamnesis using special questionnaires and scales and conducting functional tests with registration of the parameters of the cardiovascular system (heart rate, blood pressure, HRV). The most common and informative functional tests: deep controlled breathing test, orthostatic test (active and passive), Valsalva test. Promising methods for diagnosing ADS include accelerometric tremorography and the study of baroreflex sensitivity. Also, for a deeper examination of a young athlete, it is recommended to use laboratory diagnostic methods to identify violations of the endocrine system, detect changes in lipid and carbohydrate metabolism, etc. Conclusions: At the moment, further research is needed to study the autonomic dysfunction syndrome and methods for its diagnosis.
Medullary Sponge Kidney: Clinical and Radiological Manifestations
Authors:   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Fedotov A.N. , Sheikh Zh.V. ,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Tyurin I.E. ,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency, Safonova T.D. ,   Burnasyan State Research Center – Federal Medical Biophysical Center of Federal Medical Biological Agency
Published: December 2022

The paper describes a case of medullary sponge kidney with gross hematuria in a 69-year old woman. The case is of interest due to the rarity of the disease and the difficulty of recognition for both the radiologist (the results of computed tomography are non – specific), and for the attending physician (due to the poor clinical finding). Medullary sponge kidney is a benign congenital abnormality characterized by the formation of diffuse, bilateral medullary cysts caused by abnormalities in pericalyceal terminal collecting duct. The etiology is unknown, but in approximately 5 % of cases there is a genetic predisposition, according to the autosomal dominant type of inheritance. Literature review and a case study of medullary sponge kidney are presented. CT urography is one of the methods of choice in this pathology, and its value is especially great in recognizing the causes of complications of the disease, such as nephrolithiasis and macrohematuria. Purpose: to increase the awareness of practicing radiologists about CT signs of medullary spongy kidney. Material and methods: the data from the literature, as well as our own observation of the developmental abnormality – medullary spongy kidney – are presented. Results: CT scan capabilities in the diagnosis of medullary spongy kidney are described. Conclusion: CT is not the only, but an important method of diagnosis of medullary spongy kidney and knowledge of its pathophysiology and radiological manifestations will allow to make a correct diagnosis in time and prescribe the appropriate treatment.
Plant Community Structure and Biodiversity Patterns In Chattogram Metropolitan City of Bangladesh
Authors: Faruque Mohammad Omar , Rudra Sajib , Rahman Md Khondakar Raziur , Hossain Md Arif , Hossen Imam , Barman Sanatan Chandra , Mustakim Md , Hossain Md Ikramul , Uddin Shaikh Bokhtear
Published: December 2022

The present study aims at investigating the vegetation in different sites of Chattogram metropolitan area following appropriate techniques. In order to enumerate the distribution of species, several diversity indices including Shannon-Winer Index, Pielou’s Evenness and Simpson’s Index were employed. A total of 645 species belonging to 414 genera under 120 families were documented from the studied area for the first time. Of these, 37 species (5.73%) are pteridophytes, 607 species (94.11%) are angiosperms and single representation of gymnosperm (0.16%). Among the recorded species, 384 are medicinal species belonging to 277 genera under 93 families. Bacopa monnieri is a dominant species in the forest area with some co-dominant species like Eichhornia crassipes, Centella asiatica, etc. Moreover, this study provides potential sources to the environmental planners, herbalists, ecologists, taxonomists, ethnobotanists, pharmacists, phytochemists and local administration that would help to plan for future green infrastructure and maintain ecosystem function providing long-term benefits for the city dwellers.
Bangladesh J. Plant Taxon. 29(2): 313-344, 2022 (December)
Taxonomic Revision of the Subfamily Sterculioideae Beilschm. In Bangladesh
Authors: Ahmed Sheikh Sunzid , Rahman M Oliur
Published: December 2022

The subfamily Sterculioideae Beilschm. of Malvaceae has been revised for Bangladesh which revealed 16 taxa belonging to five genera, such as Firmiana Marsili, Heritiera Ait., Pterygota Schott & Endl., Scaphium Schott & Endl. and Sterculia L. The genus Sterculia is unveiled with the highest number of taxa, whereas both Pterygota and Scaphium are represented with single taxon. Dichotomous bracketed keys to genera and species are constructed for easy identification. Each taxon is presented with an updated nomenclature, description of the taxa along with illustrations, specimens examined, phenology, notes on distribution and economical importance. In most cases, chromosome number has been provided.
Bangladesh J. Plant Taxon. 29(2): 373-401, 2022 (December)
Modelos de Series de Tiempo para Predecir el Número de Casos de Variantes Dominantes del SARS-COV-2 Durante las Olas Epidémicas en Chile
Authors: Barría-Sandoval Claudia
Published: December 2022

El COVID-19 y sus variantes han creado una pandemia a nivel global. En Chile, hasta el 28 de febrero del 2022, ya se han infectado más de 3 millones de personas y han muerto más de 42 mil personas. En este artículo, se realiza un estudio comparativo de diferentes modelos matemáticos utilizados para modelar y predecir el número de casos diarios confirmados de COVID-19 en Chile. Esta investigación considera los registros diarios de casos confirmados desde el inicio de la pandemia y por lo tanto incluye los contagiados por las distintas variantes del virus (Delta, Gamma y Omicron), estas variantes han dominado la evolución de los contagios diarios en Chile, siendo la variante Omicron la que ha demostrado tener una mayor tasa de contagios a nivel nacional. El objetivo de este estudio es brindar información relevante sobre la evolución de la pandemia por COVID-19 en Chile mediante modelos de series de tiempo que han sido validados en distintas investigaciones y evaluar su precisión frente a la variante Omicron del virus SARS-CoV-2.
Análisis de Correspondencias Múltiples para el Estudio de los Homicidios Intencionales en el Ecuador
Authors: Abril Donoso Mauricio Enrique , Chariguamán Maurisaca Nancy Elizabeth , Aguilar Reyes Johanna Enith
Published: December 2022

El presente estudio permite analizar las relaciones entre las categorías de variables asociadas con los homicidios intencionales en el Ecuador, por medio del Análisis de Correspondencias Múltiples, para determinar las relaciones entre las modalidades que influyen y contribuyen al cometimiento de este tipo de violencia. Esto permite optimizar la elaboración e implementación de política pública para reducir y erradicar los niveles de violencia que se tiene en el país. Se obtiene que el tipo de muerte violenta depende principalmente de la provincia en la que se produce, con un tipo de arma y en rangos etarios de personas jóvenes. Estos resultados permiten el tratamiento desde diferentes áreas del conocimiento para mitigar este fenómeno de violencia y garantizar un adecuado nivel de seguridad a la ciudadanía.
ANALISA DESKRIPTIF PENGELOMPOKAN DATA KONSENTRASI PM2,5 BERDASARKAN HARI PADA TITIK PEMANTAUAN BUNDARAN HI JAKARTA UNTUK DATA FEBRUARI-OKTOBER 2021
Authors: Nelvidawati Nelvidawati
Published: December 2022

The very high flow of vehicles passing through Bundaran HI has resulted in a decrease in air quality in this area. PM2,5 is one of the pollutant substances produced from vehicle fumes that can be harmful to health. The number of vehicles that pass through this area depends on the presence of office and business activities. The purpose of this study was to determine the pattern of distribution of PM2.5 concentration data by day and how much data did not exceed the quality standard. The research was conducted by descriptive method. The results showed that the pattern of distribution of PM2.5 data which was below the quality standard occurred in February to mid-April 2021 and early June to early July. This is due to the PSBB and PPKM that apply in the city of Jakarta. When the regulation was revoked, the concentration of PM2.5 was more dominant above the quality standard. If the data is grouped by day, the percentage of PM2.5 concentration data that does not pass the quality standard is Monday 43.59%, Tuesday 35.89%, Wednesday 38.46%, Thursday 41.02%, Friday 41.03%, Saturday 56 .41%, Sunday 41.02%..
LAND SURFACE CHANGES DUE TO BUKITTINGGI CITY EARTHQUAKE USING THE 2019-2020 DInSAR METHOD
Authors: Fikri Saiyidinal , Syafriani Desi , Hasanah Fitra
Published: December 2022

Bukittinggi city is in the sink segmentation "semangko" fault line, which causes Bukittinggi City to frequently experience earthquakes. From 2019 to 2020, there have been at least 9 earthquakes above 5 on the Richter scale. DInSAR is a radar imaging method that utilizes phase, amplitude, and wavelength in its processing to obtain topography and land surface changes. This study has three aims. This research shows that the earthquake from 2019 to 2020 uses 18 pairs of sentinel-1 image scans recorded in 2019-2020 and uses DEM SRTM 30, namely the earthquake that happened on February 2, 2019, in the sub-district of Guguak Panjang with a range of 1 – 45 mm. The smallest increase occurred in the sub-district of Guguak Panjang and Mandiangin Koto Selayan, with a length of 1 mm on November 11, 2019. The most significant reduction happened in the sub-district of Aur Birugo with -22 mm. In contrast, a less substantial reduction occurred in the sub-district of Guguak Panjang with -5 mm on October 8, 2019. The Modified Mercalli intensity scale for earthquakes in 2019-2020 uses the measure of Donovan's parameters demonstrated by numbers 2, 3, and 4. Number 2 indicates that resting people feel the earthquake's strength, especially hanging, shaking, and vibrating on the second floor. Number 3 represents the vibrations of passing trucks, windows, doors, and glassware clashing and making noises
Futbolda Uygulanan Video Yardımcı Hakem Sistemi Hakkında Taraftar Tutumlarını Belirlemeye Yönelik Ölçek Geliştirme Çalışması
Authors: Tabuk Mustafa Ertan
Published: December 2022

Bu çalışma futbolda kullanılan Video Yardımcı Hakem (VAR) sistemine yönelik taraftar tutumlarını belirlemek amacıyla yapılan bir ölçme aracı geliştirme araştırmasıdır. Çalışma genel tarama modeli kullanılan betimsel bir araştırmadır. Araştırmanın grubu VAR sisteminin uygulandığı süper lig profesyonel futbol kulüplerinin taraftarlarıdır. Araştırmaya 397 katılımcı gönüllü olarak katılmıştır. Veriler, spor kulüplerinin taraftar gruplarının sosyal medya hesapları aracılığıyla web tabanlı olarak toplanmıştır. Geliştirilen ölçme aracına açıklayıcı ve doğrulayıcı faktör analizleri yapılmış ve uyum iyiliği indekslerine uygun değerler elde edilmiş, geliştirilen ölçeğin geçerlilik ölçütlerine uygunluğu tespit edilmiştir. Ölçme aracının iç tutarlık katsayısı α=,873 tespit edilerek ölçme aracının güvenilir olduğu ve alt boyutlarında hedeflenen özellikleri ölçtüğü ve geçerli olduğu sonucuna ulaşılmıştır. “Video Yardımcı Hakem Sistemi Taraftar Tutum Ölçeği” adı verilen ölçme aracı 9 ifadeli 7’li likert tipi ile hazırlanmış, futbola katkı, oyun yönetimi ve yarışma baskısı adı verilen 3 alt boyuttan oluşmaktadır. Araştırma sonucunda VAR sitemine karşı taraftar tutumlarını ölçmek amacıyla kullanılabilir, geçerli ve güvenilir bir ölçek oluşturulmuştur.
Knowing me, knowing you: the evolution of HTA practice and approaches from the perspectives of HTA Agencies and pharmaceutical industry
Authors:   , Wang Ting
Published: December 2022

Health Technology Assessment (HTA) has emerged as an important tool to support healthcare decision-makers to make rational reimbursement decisions, with the ultimate purpose of promoting an efficient healthcare system.
HTA agencies continue to review their methodology and refine processes and procedures to improve their practice. For pharmaceutical companies, HTA needs to be embedded from development to jurisdictional submission to HTA agencies. Interactions between HTA agencies and companies through the form of early scientific advice have been increasingly used to support evidence generation during development, in order to improve market access. Multi-stakeholder interactions between regulator, HTA agencies and companies need to be further mapped out and evaluated to assess the current experience, uptake, and value of such activities.
This research is aimed to evaluate the HTA practice of pharmaceutical companies to enable better decision-making during development and at launch, examine the processes and performance of HTA agencies, and promote good practice across both stakeholders through self-improvement and interactions.
The finding in this thesis has demonstrated a continuous evolution of HTA agencies throughout product lifecycles to support drug development, improve their methodology and processes, and engage in interaction with regulators and peer HTA agencies. By establishing a systematic framework to benchmark the organization and milestone performance of HTA agencies, we provided a baseline and tool to assess the evolvement of HTA. We also observed a mindset change within companies to embed HTA considerations during drug development, in order to improve the jurisdictional submission and proactively promote good HTA practice.
Future opportunities for research can be built on this thesis in the context of lifecycle HTA. For example, indicators can be established to measure the interactions between agencies through development to review and assessment of new medicine. The agency benchmarking framework can be utilised as a foundation for capacity building for emerging HTA agencies, tracking and improve performance metrics and ensuring a good practice of HTA.
NILAI PENDIDIKAN KARAKTER DAN PEMBELAJARAN BAHASA INDONESIA DALAM NOVEL SI ANAK CAHAYA KARYA TERE LIYE
Authors: Haryadi Haryadi , Supriatini Supriatini , Danto Danto
Published: December 2022

Penelitian ini bertujuan untuk mendeskripsikan nilai-nilai pendidikan karakter dalam novel Si Anak Cahaya Karya Tere Liye. Metode penelitian ini adalah deskriptif kualitatif. Hasil penelitian mengandung sepuluh nilai pendidikan karakter sebagai berikut. (1) religius, (2) toleransi, (3) disiplin, (4) kerja keras, (5) mandiri, (6) demokratis, (7)  semangat kebangsaan, (8) cinta tanah air, (9) peduli sosial, (10) tanggung jawab. Penelitian ini dapat disimpulkan bahwa nilai-nilai pendidikan karakter yang digambarkan melalui kehidupan para tokoh, tingkah laku, dan karakter yang ada dalam diri para tokoh. Nilai pendidikan karakter yang paling baik dijadikan bahan ajar bahasa Indoneia.  Hal ini akan memudahkan siswa untuk mengimplementasikan nilai yang terkandung dalam novel Si Anak Cahaya Karya Tere Liye sehingga dapat diterapkan dalam kehidupan sehari-hari. Rekomendasi yang dapat dikemukakan bahwa sikap ddn perilaku para tokoh dapat dijadikan contoh untuk menanamkan nilai karakter dalam diri siswa.
GAMBARAN SIKAP BAHASA MAHASISWA PBI UNU PURWOKERTO TERHADAP PENGGUNAAN BAHASA BAIK DAN BENAR
Authors: Mustikasari Dian , Purwani Rina
Published: December 2022

Penelitian ini bertujuan untuk menndiskripsikan gambaran sikap bahasa mahasiswa terhadap penggunaan bahasa baik dan benar dalam lisan maupun tulis. Banyak ditemukan mahasiswa dalam mengerjakan tugas seperti paper atau makalah masih menggunakan bahasa yang tidak sesuai kaidah Bahasa Indonesia.

Rumusan masalah dalam penelitian ini adalah bagaimana gambaran sikap bahasa mahasiswa prodi PBI di Universitas Nahdlatul Ulama Purwokerto terhadap penggunaan bahasa baik dan benar dalam lisan maupun tulis.

Metode yang digunakan adalah dengan pendekatan diskripsi kuantitatif yang menggunakan metode survei. Penelitian akan mendeskripsikan secara menyeluruh yang berhubungan dengan temuan yang bersumber pada instrument utama yaitu angket yang berisi kuisoner. Hasil dari penelitian diolah memakai uji analisis deskriptif dengan pernyataan positif yang tinggi di aspek kesetiaan 41,4%, kebanggaan 44,8%, dan kesadaran 41,4% yang rata-rata tertinggi setuju diantara lima point lainnya, Dapat dikatakan bahwa mahasiswa memiliki sikap bahasa dalam penggunaan bahasa yang baik dan benar yang  positif.
Испытания листового монолитного поликарбоната для конструкций покрытий
Authors: АВДЕЕВ Кирилл Владимирович , БОБРОВ Владимир Викторович , ТУЧИН Михаил Александрович , КУДРЯВЦЕВ Никита Андреевич , СКАКУН Павел Владимирович
Published: December 2022

Исследование физико-механических свойств монолитного поликарбоната служит основой для дальнейшего изучения различных критериев, влияющих на свойства материала при использовании его в строительстве. Ввиду отсутствия специальных методик определения физико-механических свойств поликарбоната, как отдельного типа пластмасс, необходимо экспериментально подтвердить, что общие принципы испытания пластмасс подходят и для поликарбоната. Проведен аналитический обзор действующих в России методов испытания пластмасс и испытаны образцы поликарбоната. Анализ результатов испытаний, проведенных авторами, данных отечественных и зарубежных производителей, а также ранее опубликованных результатов исследований позволил оценить применимость действующих методов испытания не только для пластмасс, но и для монолитного поликарбоната. Были получены усредненные данные по физико-механическим свойствам, которые необходимы для проведения общих строительных расчетов. Подтверждена пригодность отечественных методик испытания пластмасс для монолитного поликарбоната, но с учетом приведенных в статье рекомендаций.
Effective reduction of need for non-steroid anti-inflammatory drugs on background of intra-artular introduction of sodium hyauloranate in patients with gonarthrosis
Authors: Sivordova L. E. , Polyakova Yu. V. , Papichev E. V. , Akhverdyan Yu. R. , Zavodovsky B. V.
Published: December 2022

Introduction. Osteoarthritis (OA) in the Russian Federation is still not included in the list of socially significant diseases, despite the fact that this pathology limits the level of physical activity of the population more than diseases of the cardiovascular system, visual impairment and diabetes. European experts emphasize the relevance of research to develop methods to improve the effectiveness of viscosupplementary therapy in OA. The purpose of the study. To evaluate the efficacy, safety and long-term results of treatment of gonarthrosis with sodium hyaluronate.

Materials and methods. The study included 180 patients with gonarthrosis with insufficient efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) on demand and oral symptomatic slow-acting drugs against osteoarthritis (SYSADOA). The patients were randomized into three groups. Group 1: 50 patients who received sodium hyaluronate (Ripart®; Ingal, Russia) intra-articularly. Group 2: 30 patients received intra-articular SYSADOA (bioactive concentrate of small marine fish). The control group consisted of 100 patients who received drugs of the SYSADOA group intramuscularly.

Results. An effective reduction in pain both at rest and during movement was achieved in most patients of all groups, but the treatment groups differed statistically significantly in the speed of achieving the clinical effect and its duration. In the 1st group, a significant decrease in the VAS pain index was observed already at the 1st week and by the 3rd month it was –49.1 % (p < 0.001). In the comparison and control groups, the indicators of speed, the degree of pain reduction, and the duration of the effect of therapy were also significant (p ≤ 0.050). But the effectiveness of therapy in these groups was statistically significantly lower than in patients of group 1 (p ≥ 0.050). It should be emphasized that the intra-articular administration of sodium hyaluronate provided a significant reduction in the need for patients to additionally take NSAIDs. After 3 months of therapy, only 5 patients (10 %) of this group continued to take NSAIDs (p < 0.001); 20 – completely stopped taking NSAIDs (40 %) and 25 (50 %) reduced the dose of NSAIDs taken, the duration of the effect lasted up to 12 months.

Conclusions. In our study, sodium hyaluronate demonstrated high efficiency in reducing pain in patients with gonarthrosis and contributed to a significant decrease in the need for patients to take NSAIDs for 12 months.
Damage of cardiovascular system in patients with rare systemic diseases: example of recurrent polychondritis (case from practice)
Authors: Rybas A. V. , Jazaeva M. B. , Pashkova I. N.
Published: December 2022

A clinical case of recurrent polychondritis with damage to the cardiovascular system in the form of the development of acute coronary syndrome is presented. Recurrent polychondritis is a rare systemic presumably autoimmune disease that is affecting cartilage tissue. The main cause of high mortality in patients with systemic diseases is the early formation and accelerated progression of atherosclerotic vascular lesions that cause the development of myocardial infarction, stroke, chronic heart failure and sudden death. Recurrent polychondritis is characterized by clinical polymorphism. The diagnosis of the disease requires the interdisciplinary medical participation of at least five specialists.
KALP HIZI DEĞİŞKENLİĞİ VE EGZERSİZE KRONİK YANITLARI
Authors: ARAS Dicle , ERDOĞMUŞ Tuğçe Nur , AYVAZ Özkan , BİROL Abdulkadir
Published: December 2022

Bu derleme çalışmanın amaçlarından biri; kalp hızı değişkenliği kavramı ve bileşenlerini, kalp hızı değişkenliği ölçüm yöntemlerini ve kalp hızı değişkenliği üzerinde etkili olan parametreleri incelemekti. Çalışmanın diğer amacı da sağlığa ilişkin birçok faydası olduğu bilinen egzersizin, sağlıklı yetişkinlerde kalp hızı değişkenliği üzerindeki kronik etkilerinin tartışılması idi. Bu amaçla otonom sinir sistemi, kalp hızı değişkenliği ve egzersiz/düzenli fiziksel aktivite/fitness sözcükleri belirli bilimsel indekslerde incelenmiş ve konuyla ilgili çalışmalar ele alınmaya çalışılmıştır.
SPOR VE MÜZİK BÖLÜMLERİNDE ÖĞRENİM GÖREN ÖĞRENCİLERİN SOSYAL KAYGI DÜZEYLERİNİN ÇEŞİTLİ DEĞİŞKENLERE GÖRE KARŞILAŞTIRILMASI
Authors: BATU Batuhan , YILMAZ Hüseyin
Published: December 2022

Bu araştırmada spor ve müzik bölümlerinde öğrenim gören öğrencilerin sosyal kaygı durumlarının incelenmesi amaçlanmıştır. Çalışma grubunu 2021-2022 eğitim öğretim döneminde Kafkas Üniversitesi Devlet Konservatuvarı ile Sarıkamış Beden Eğitimi ve Spor Yüksekokulu’nda öğrenim gören öğrenciler (n=180) oluşturmaktadır. Araştırma genel tarama ve nedensel karşılaştırma modeli temel alınarak yapılmıştır. Veri toplama aracı olarak “Kişisel Bilgi Formu” ve “Sosyal Kaygı Ölçeği” kullanılmıştır. Verilerin analizinde bağımsız t-testi ve tek yönlü varyans analizi (ANOVA) uygulanmıştır. Araştırmanın sonucunda spor ve müzik bölümlerinde öğrenim gören öğrencilerin sosyal kaygı düzeylerinde cinsiyet değişkenine göre anlamlı farklılık olduğu, gelir düzeyi, sınıf ve bölüm gibi değişkenlere göre ise anlamlı düzeyde bir farklılık olmadığı saptanmıştır.
PROBLEMS FACED BY SPORTS INSTRUCTORS WORKING IN AUTISM SPORTS CLUBS
Authors: USTAOĞLU HOŞVER Pelin , KARADAĞ Öznur , AKPINAR Selahattin
Published: December 2022

In recent studies, the positive contributions of physical activity, physical education and sports to the lives of individuals with special needs are frequently mentioned. The presence of trainers and physical education teachers who conduct these activities for individuals with special needs is as important as physical activity, physical education and sports. Considering the difficulty of the education process of individuals with special needs compared to the education process of other individuals, it is thought that educators face relatively more various problems in the education process. From this point of view, the aim of this research is to examine the problems faced by trainers working in autism sports clubs. Qualitative research method was used in the research. 17 trainers working in autism sports clubs participated in the research voluntarily. Data were collected by semi-structured interview technique. Content analysis method was used in the analysis of the data. The reliability of the study was calculated using the Miles and Huberman (1994) formula and it was found that a consensus of 77% was achieved. In line with the answers given by the participants, three main themes were reached under the headings of family, children and environment. Under the main theme of family, 'insecurity, inadequacy in education, ignorance about autism, intrusive attitude, not accepting autism, non-cooperation and lack of communication', under the main theme of children 'aggressive behavior and varying negative behaviors', under the main theme of environment 'insensitivity, autism-related 'ignorance and discrimination' codes have been reached. As a result, it can be said that the problems faced by the participants are based on three different sources: family, child and environment. Depending on these results, it can be said that making families more conscious and environmental regulations will be effective in minimizing the problems faced by educators.
Farklı formaldehit/üre oranına sahip UF tutkalı ile üretilmiş yönlendirilmiş yonga levhaların (OSB) bazı fiziksel ve mekanik özellikleri
Authors: DOĞAN Kadir , KAYMAKCI Alperen
Published: December 2022

Bu çalışmanın amacı; farklı formaldehit/üre oranı ile üretilmiş üre formaldehit (UF) tutkalı kullanılarak üretilmiş yönlendirilmiş yonga levhaların (OSB) bazı fiziksel ve mekanik özelliklerinin belirlenmesidir. Bu amaçla yerel bir levha tesisinde farklı formaldehit/üre oranına sahip tutkallar ile 2440 x 1220 x 11 mm ölçülerinde levhalar üretilmiştir. Elde edilen levhalar standartlara uygun boyutlarda kesildikten sonra TS EN standartlarına uygun olarak testleri yapılmıştır. Sonuçlar incelendiğinde; 1.250 mol oranına sahip tutkal ile üretilen levhaların yoğunluk ortalaması 596 kg/m³, 24 saat kalınlık şişme değeri ortalama %26.3 iken, 1.10 mol oranına sahip tutkal ile üretilen levhaların yoğun ortalaması 603 kg/m³, 24 saat kalınlık şişme değeri ortalama değeri %25.9 olarak ölçülmüştür. Levhaların üretim yönüne doğru ve üretim yönüne dik olarak yapılan eğilme direnci değeri ve yüzeye dik çekme direnci değerlerinde önemli bir fark görülmemiştir. 1.250 mol oranına sahip tutkal ile üretilen levhaların serbest formaldehit değeri ortalama 14.1 mg/100g iken, 1.10 mol oranına sahip tutkal ile üretilen levhaların serbest formaldehit değeri 7.01 mg/100g ölçülmüştür.
ПОЛІПШЕННЯ ЕКСПЛУАТАЦІЙНИХ ПОКАЗНИКІВ ТРАНСПОРТНОГО ДВИГУНА ПРИ РОБОТІ НА СПИРТОВМІСНОМУ БЕНЗИНІ
Authors:   Національний транспортний університет, ГУТАРЕВИЧ Юрій , ТРІФОНОВ Дмитро , ШУБА Євгеній
Published: December 2022

Транспорт став невід'ємною частиною сучасного життя і одним з ключових секторів з точки зору споживання енергії. Двигун внутрішнього згорання (ДВЗ), що працює на викопному паливі, є одним з найбільш ефективних і універсальних джерел механічної енергії, що застосовується в автомобілях, будівельних та сільськогосподарських машинах, стаціонарних енергетичних установках та ін. Нестабільність світових цін на викопне паливо, скорочення його запасів, проблеми з транспортуванням змушують шукати альтернативи традиційному паливу. Застосування альтернативних видів палив повинно знижувати екологічний збиток, що наноситься навколишньому середовищу, який пов'язаний з використанням викопних палив. Розвиток ринку альтернативних видів палива має знизити залежність від нафти та сприяти підвищенню безпеки енергопостачання України, сприяти економічному зростанню та скороченню викидів парникових газів на транспорті. Зниження впливу автомобільного транспорту на забруднення навколишнього середовища є одним з найважливіших пріоритетів державної політики в галузі автомобільного транспорту.
SMART LOGISTICS WITHIN THE FRAMEWORK OF THE CONCEPT OF CYBER-PHYSICAL SYSTEMS
Authors:   National Transport University, DANCHUK Viktor , WEIß Christian ,   Hochschule Ruhr West University of Applied Science, SVATKO Vitaliy ,   National Transport University
Published: December 2022

The most effective solution to the problems associated with accelerated motorization under modern conditions is the implementation of the concept of Smart Logistics, namely the development, implementation and application of Intelligent Transportation Systems (ITS), where the effective use of modern intelligent technologies of the Internet of Things (IoT), blockchain (BC), Big Data (BD) and Artificial Intelligence (AI). However, fundamental and applied theoretical research on Smart Logistics today is largely fragmented, since it is carried out by scientists in different subject areas. These research activities are aimed at solving problems of practical application in various, at best related, sectors of the innovative development of society. Therefore, these scientists have a different vision of ways to improve the efficiency of functioning and development of Smart Logistic, which leads to the formation of different approaches. In addition, the use of intelligent information technologies for the effective organization, optimization and management of logistics processes for the implementation of freight and passenger transportation in real time with a large and variable workload of the automotive urban road network (URN) is episodic and imperfect. One of the important reasons for this is the lack of adequate methods for discrete optimization of routes with dynamic updates that take into account the real dynamics of traffic flows (TF) on sections of URN.
Pemahaman Bidan Terkait Peraturan Daerah No. 5 Tahun 2014 tentang Inisiasi Menyusui Dini dan ASI Eksklusif
Authors: Octaviani Dhita Aulia , Musdalifah Ulfah
Published: December 2022

Kabupaten Semarang, Provinsi Jawa Tengah merupakan kabupaten/kota yang menduduki peringkat empat terendah dalam cakupan pemberian ASI eksklusif, yaitu 50,7% pada tahun 2018, meskipun sudah terdapat dukungan regulasi berupa Perda Nomor 5/2014 tentang IMD dan ASI eksklusif. Penelitian ini bertujuan mengetahui gambaran implementasi Perda Nomor 5/2014 tentang inisiasi menyusui dini (IMD) dan ASI eksklusif pada bidan di Kabupaten Semarang dan menganalisis faktor-faktor yang memengaruhinya. Penelitian ini merupakan penelitian kuantitatif dengan desain observasional analitik dan pendekatan cross-sectional. Jumlah sampel sebanyak 38 bidan di Kabupaten Semarang yang memenuhi kriteria inklusi. Pengambilan data dilakukan menggunakan kuesioner yang telah diuji validitasnya. Hasil penelitian menunjukkan terdapat hubungan antara pendidikan, lama bekerja, implementasi Perda No 5 tahun 2014 dengan praktik bidan terhadap IMD dan pemberian ASI eksklusif. Pemahaman bidan akan ketentuan-ketentuan yang tercantum di dalam Perda tersebut perlu ditingkatkan lagi terutama pada informasi mengenai IMD dan ASI eksklusif yang harus diberikan sejak pemeriksaan kehamilan sampai periode pemberian ASI eksklusif selesai. Semakin baik pemahaman bidan mengenai isi dari Perda No 5 Tahun 2014 tentang IMD dan ASI Eksklusif, maka praktik bidan terhadap pelaksanaan IMD dan ASI Eksklusif pun juga semakin baik.
Pengaruh Pemberian Metode 20-20-20 terhadap Penurunan Gejala Computer Vision Syndrome (CVS)
Authors: Nurhikma Gita , Setyowati Dina Lusiana , Ramdan Iwan Muhamad
Published: December 2022

Computer Vision Syndrome (CVS) adalah kombinasi masalah atau sekumpulan gejala pada mata akibat aktivitas penggunaan perangkat digital seperti komputer, telepon, dan tablet dengan penglihatan jarak dekat dan berlangsung secara terus menerus. Pekerja yang menggunakan komputer dengan durasi lebih dari 2-4 jam sehari beresiko mengalami CVS dan dapat berdampak pada produktivitas kerjanya. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian metode 20-20-20 terhadap penurunan gejala CVS. Jenis penelitian ini adalah true experimental desain pretest-posttest control group design. Jumlah sampel sebanyak 30 orang karyawan dan dibagi menjadi kelompok eksperimen dan kelompok kontrol. Analisis bivariat menggunakan uji paired samples T-test untuk sampel berpasangan dan uji independent samples T-test dan Mann-Whitney untuk sampel tidak berpasangan dengan tingkat signifikansi 95% (α=0,05). Hasil penelitian menunjukkan adanya perbedaan yang bermakna antara skor gejala CVS sebelum dan sesudah intervensi dengan nilai ρ=0,001 (ρ < 0,05). Peneliti menyimpulkan bahwa ada pengaruh yang signifikan dari pemberian metode 20-20-20 terhadap penurunan gejala CVS pada karyawan. Peneliti selanjutnya diharapkan dapat berinovasi untuk menurunkan gejala Computer Vision Syndrome (CVS).
Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice
Authors: Zhang Wenjie , Shi Bowen , Li Shirui , Liu Zenglin , Li Songhan , Dong Shuohui , Cheng Yugang , Zhu Jiankang , Zhang Guangyong , Zhong Mingwei
Published: December 2022

Introduction

Obesity is a metabolic disease accompanied by abnormalities in lipid metabolism that can cause hyperlipidemia, non-alcoholic fatty liver disease, and artery atherosclerosis. Sleeve gastrectomy (SG) is a type of bariatric surgery that can effectively treat obesity and improve lipid metabolism. However, its specific underlying mechanism remains elusive.

Methods

We performed SG, and sham surgery on two groups of diet-induced obese mice. Histology and lipid analysis were used to evaluate operation effect. Immunohistochemistry, immunoblotting, real-time quantitative PCR, immunoprecipitation, immunofluorescence and mass spectrometry were used to reveal the potential mechanisms of SG.

Results

Compared to the sham group, the SG group displayed a downregulation of deubiquitinase ubiquitin-specific peptidase 20 (USP20). Moreover, USP20 could promote lipid accumulation in vitro. Co-immunoprecipitation and mass spectrometry analyses showed that heat-shock protein family A member 2 (HSPA2) potentially acts as a substrate of USP20. HSPA2 was also downregulated in the SG group and could promote lipid accumulation in vitro. Further research showed that USP20 targeted and stabilized HSPA2 via the ubiquitin-proteasome pathway.

Conclusion

The downregulation of the USP20-HSPA2 axis in diet-induced obese mice following SG improved lipid dysmetabolism, indicating that USP20-HSPA2 axis was a noninvasive therapeutic target to be investigated in the future.