bluuebunny/crossref_metadata_2025 huggingface dataset:
Thematic and Methodological Analysis of National and International Theses on Curriculum Implementation
Authors: ÇELİKER ERCAN Gülçin , CUBUKCU Zühal
Published: May 2023

The current study aims to conduct a thematic and methodological analysis of national and international theses on curriculum implementation. The theses to be included in this study, which was designed as descriptive content analysis, were determined by criterion sampling, one of the purposive sampling methods. A total of 363 theses, 21 national and 342 international, were included in the study. Research data were collected with the "Thesis Evaluation Form" developed by the researchers. In the content analysis of the data, categorical analysis and frequency analysis were used. The results of the research showed that the implementation of the curriculum in national theses was mostly discussed under the theme of curriculum development and curriculum evaluation, while in international theses, the themes studied on the curriculum implementation were more diverse and specific to the implementation process of the curriculum. While mixed methods and quantitative research methods were preferred in national theses, qualitative research methods were mostly used in international theses. In accordance with the selected research method, mixed method research designs, maximum diversity and convenience sampling methods, use of interviews and scales, descriptive statistics and content analysis were utilized in national theses. On the other hand, in international theses, qualitative case study design, purposeful sampling method, data collection through interviews, observations and documents, and data analysis with coding technique were frequently employed. The sample group of both national and international theses is mostly teachers. It is thought that the findings obtained within the scope of this research will be useful in terms of understanding the studies on the implementation of the curricula and guiding future studies to be carried out in the field.
Inventory credit, a system to improve food security in sub-Saharan Africa
Authors: Le Cotty Tristan , Maître d’Hôtel Élodie , Porgo Issoufou , Subervie Julie , Soubeyran Raphaël
Published: May 2023

Inventory credit is being developed in several Sahelian countries. This device is implemented by a farmers’ organisation and a financial institution. It consists in storing a portion of harvested grain in a warehouse for several months in exchange for an individual loan. Without this loan, farmers tend to sell their grain immediately after harvesting in order to pay off their debts or to meet their needs. The consequence is that families subsequently struggle to get through the lean season – the transition period between the depletion of food stocks and the new harvest – and to invest in their agricultural production systems. An impact assessment study conducted in western Burkina Faso shows that inventory credit increases food availability in the lean season and boosts agricultural investment and production. To accelerate its development, three conditions must be met: providing access to suitable storage facilities; ensuring the quality of products stored; and building trust between financial institutions, producers’ organisations and traders. The latter condition is undermined by the expansion of armed conflicts in the Sahel.
Inteligência Artificial, Educação e Responsabilidade Social
Authors: Baranauskas Maria Cecília Calani , Valente José Armando
Published: May 2023

Esta edição resulta de submissões de trabalhos estendidos da II International Conference in Information Technology & Education (ICITED) à revista. Nesta edição, a Revista Tecnologias, Sociedade e Conhecimento divulga um trabalho de pesquisa relacionado à mensuração do desempenho acadêmico de estudantes do ensino secundário em Portugal, realizada por meio de métodos da Inteligência Artificial (IA). Dados dos exames nacionais de matemática e português da população portuguesa no ano letivo 2018/2019 são utilizados para alimentar algoritmos de IA e levantar fatores que afetam os resultados dos estudantes nesses exames.

A contribuição deste volume para o espaço de discussão da revista foi escrita por cinco autores afiliados à Nova Information Management School, uma escola de Gestão de Informação e de Ciência de Dados da Universidade Nova de Lisboa. O trabalho envolve a temática do desempenho acadêmico, medida por meio de métodos e tecnologias de IA, com potencial impacto em políticas públicas.
Central lymphatic surgery
Authors: Grünherz Lisanne , Lindenblatt Nicole
Published: May 2023

In recent years, microsurgical reconstruction of the lymphatic system has opened new frontiers in the treatment of central lymphatic lesions. Central lymphatic lesions can be congenital or acquired. While the latter can result from any surgery or trauma in the area of the thoracic duct, congenital lymphatic lesions can show a plethora of manifestations, ranging from singular thoracic duct abnormalities to complex multifocal malformations. Regardless of the anatomical location of the thoracic duct lesion, these conditions cause recurrent chylous effusions and downstream lymphatic congestion and are associated with increased mortality due to the permanent loss of protein and fluid. In case of disruption of the lymphatic flow, microsurgical reconstructive surgery is indicated to treat downstream congestion leading to bronchitis plastica, protein-loosing enteropathy, chylothorax, and chylascites. Thoracic duct-vein anastomoses can reconstruct the physiological lymphatic flow.
Pressure resistance evaluation in esophagojejunostomy using the transorally inserted anvil (OrVilTM)
Authors: Yamauchi Suguru , Kanda Satoshi , Orita Hajime , Yoshimoto Yutaro , Kubota Akira , Tsuda Kenki , Yube Yukinori , Kaji Sanae , Brock Malcolm V. , Mine Shinji , Fukunaga Tetsu
Published: May 2023

Aim: The transorally inserted anvil (OrVilTM) is often selected for esophagojejunostomy after total laparoscopic gastrectomy due to its versatility. During anastomosis with OrVilTM, it is possible to select a double stapling technique (DST) or a hemi-double technique (HDST) by overlapping the linear stapler and the circular stapler, although there has been no report on the anastomotic strength. Thus, an animal experiment was conducted and verified this study. Methods: This experiment used 10 fresh porcine esophageal and jejunal specimens. Two models were created: a model in which the rod is placed at the center of the esophageal transection line (DST model) and a model in which the rod is placed at the lateral end of the esophageal transection line (HDST model). A pressure gage was inserted into the anastomosed intestine while continuously measuring pressure to determine the leakage site and leakage pressure. Results: The leakage site in both the DST (n = 5) and HDST models (n = 5) were at the staple overlapping with a leakage pressure of 151.2 ± 14.2 mmHg in the DST model and 148.2 ± 6.3 mmHg in the HDST model (P = 0.678). When the leakage site was repaired with hand-sewn sutures and conducted remeasuring pressure, leakage was observed from the contralateral crossing in the DST model and the leakage pressure was 155.8 ± 12.2 mmHg. In the HDST model, all models were capable of withstanding 300-mmHg pressures. Conclusion: HDST with a single staple intersection is beneficial for esophagojejunostomy, in terms of pressure resistance, and the repairing suture at the staple intersection can increase pressure resistance.
Analysis of Skin Protection from the Dangers of Sun Exposure Using Color Variations and Types of Cotton Fabrics
Authors: Norliani Norliani , Mislan Mislan , Wardani Pratiwi Sri , Putri Erlinda Ratnasari
Published: May 2023

Cotton fabric is a comfortable clothing material to wear in tropical climates. In addition to the comfort aspect, cotton cloth is expected to be able to protect the skin from the dangers of sun exposure. This research was conducted with the aim of knowing the optimum amount of protection produced by cotton cloth, determining the type and color of cotton cloth that is most effectively used as a protector, and knowing the SPF (sun protection factor) value category based on the type and color of cotton cloth. This study used three types of cotton cloth, each consisting of four colors, as well as a Digital Environment Multimeter which was used to measure the intensity of sunlight in units of lux. The protection value is obtained by comparing the intensity of sunlight without a cotton cloth protector (lux) with the intensity of sunlight using a cotton cloth protector (lux). The results obtained show that the most optimum protection value is found in black toyobo cotton cloth with an SPF value of 54.4 and a transmittance of 1.8%. The cotton fabrics that provided the most effective protection based on type and color were black and blue toyobo, medina and Japanese cotton fabrics. Based on the SPF value obtained, it can be seen that black and blue toyobo cotton fabrics, and black madinah cotton fabrics have a very good protection category. The black and blue Japanese cotton fabrics, as well as the blue medina type, have a good protection category, while the orange Toyobo cotton fabrics have a sufficient protection category.
PERAN LEMBAGA FILANTROPI DALAM PEMBERDAYAAN PENERIMA MANFAAT USAHA MIKRO DI KOTA PADANG MELALUI PENDEKATAN CIBEST
Authors: Hayati Revi
Published: May 2023

Tujuan penelitian ini adalah untuk menjelaskan, mendeskripsikan dan menganalisis peran lembaga filantropi dalam pemberdayaan Usaha Mikro di Kota Padang melalui pendekatan Center of Islamic Business and Economic Studies (CIBEST). CIBEST adalah metode yang mengukur kemiskinan dari perspektif Islam dengan menyelaraskan aspek material dan spiritual. Pendekatan yang digunakan dalam penelitian ini adalah deskriptif kuantitatif dengan subjek penelitian penerima manfaat (PM) dari lembaga IZI, DDS dan LAZISMU Kota Padang dengan jumlah sampel sebanyak 58 orang. Teknik pengambilan sampel dengan probability sampling, sedangkan teknikpengumpulan data menggunakan metode kuesioner. Analisis data dalam penelitian ini dengan mendeskripsikan hasil kuesioner kemudian dianalisis dalam bentuk kuadran CIBEST sebagai alat ukur keberhasilan pemberdayaan usaha mikro bagi penerima manfaat lembaga filantropi. Hasil penelitian ini menunjukkan bahwa secara umum lembaga filantropi mampu mengubah PM (periode 2019-2021) dari miskin materi menjadi sejahtera sebesar 22%. Namun, hasil ini masih termasuk dalam kategori rendah. Tingkat keberhasilan lembaga DDS adalah 78% (tinggi) dengan 7 orang berhasil menjadi sejahtera. Kemudian lembaga IZI dengan tingkat keberhasilan 13% (sangat rendah) dengan 4 orang berhasil sejahtera. Selanjutnya LAZISMU dengan tingkat keberhasilan 12% (sangat rendah) dan hanya 2 orang yang berhasil sejahtera.
The purpose of this study is to explain, describe and analyze the role of philanthropic institutions in empowering Micro Enterprises in Padang City through the Center of Islamic Business and Economic Studies (CIBEST) approach. CIBEST is a method that measures poverty from an Islamic perspective by aligning material and spiritual aspects. The approach used in this research is descriptive quantitative with research subjects the beneficiaries (PM) from the institutions IZI, DDS and LAZISMU Padang City with a total sample of 58 people. The sampling technique is by probability sampling, while the data collection technique is using the questionnaire method. Analysis of the data in this study by describing the results of the questionnaire then analyzed in the form of the CIBEST quadrant as a measuring tool for the success of micro-enterprise empowerment for the beneficiaries of philanthropic institutions. The results of this study indicate that in general philanthropic institutions are able to change PM (2019-2021 period) from material poor to prosperous by 22%. However, this result is still categorized in the low category. The success rate of the DDS institution is 78% (high) with 7 people succeeding in becoming prosperous. Then the IZI institution with a success rate of 13% (very low) with 4 people managed to become prosperous. Next up is LAZISMU with a success rate of 12% (very low) and only 2 people managed to become prosperous.
Evolution of Cryptographic Algorithms and Performance Parameters
Authors:   Research scholar PG & Research Dept of Computer science, D.B.Jain College, C S Selin Chandra , S Sujin Lal ,   Assistant Professor PG & Research Dept of Computer science, D.B.Jain College, A Saranya ,   Research scholar PG & Research Dept of Computer science, D.B.Jain College
Published: May 2023

Internet and networks applications are growing very fast. Most of confidential data is circulated through networks as electronic data for achieving faster communication. In data communication Information Security became a major problem. The information is sensitive part of the organization. Any loss or threat to information can prove to be great loss to the organization. Encryption technique plays an inevitable role in information security systems. Cryptographic ciphers have an important role for providing security to these confidential data against unauthorized attacks. Though security is an important factor, there are various factors that can affect the performance and selection of cryptographic algorithms during the practical implementation of these cryptographic ciphers for various applications. This paper discuss about the data and procedures for selecting cryptographic algorithms with respect to performance.
The Natural Unit Expression of Classical Gravity
Authors: Humpherys David
Published: May 2023

The gravitational constant is equivalent to natural units in its six unit dimensions. Evaluating the classical formulas in each unit dimension shows how inputs of mass and radius are transformed into the correct unit dimensions and magnitude of gravitational potential. Mass and radial distance are equivalent proportions of the Planck scale as the potentials they produce. Gravitational potentials of velocity, acceleration, energy, and force are proportional to a radial density limit of one Planck mass per Planck length of radial distance.
Disruptive Innovation with Blockchain Technology: A Review Article
Authors: Lim Lewes , Siripipatthanakul Supaprawat
Published: May 2023

Within financial technology, Blockchain is a topic that is receiving a lot of attention and discussion. There has been a meteoric rise in engagement and recent studies on this technology. The mainframe, personal computers, the Internet, and mobile applications follow the breakthrough in the history of computing. In qualitative research, the investigation was synthesized utilizing the documentary approach, including content analysis for a review article. The results reveal that Blockchain Technology is getting a foothold not only in the financial industries but is also likely to disrupt other areas like healthcare, real estate, the legal industry, security, government, education, rentals and ride-sharing, charities and aid organizations, and politics. Currently, several projects are researching the possibility of implementing the Blockchain as a structure to support them; as a result, we will soon see that it truly becomes the technology of the future. Furthermore, qualitative interviews or focus group discussions could give more insight into details. In addition, a quantitative approach for further research could provide a generalized explanation.
Parenting, Gender, and Perception of Changes in Children's Behavior During the COVID-19 Pandemic
Authors: Vargas-Rubilar Jael , Richaud María Cristina , Balabanian Cinthia , Lemos Viviana
Published: May 2023

In a previous Argentine study, we found that, in the critical con-text of social isolation during the COVID-19 pandemic, there were changes in maternal practices that influenced the relationship with their children. We also found that the impact of mandatory isolation was moderated positively by protective factors such as positive parenting and maternal school support, or negatively by risk factors such as maternal stress. Although this study only analyzed maternal behavior, we were interested in studying the behavior of both parents, comparing the parenting (positive parenting, parental stress, and school support) of the father and mother and the perceived behavioral changes in their children. The sample consisted of 120 Argentinean parents (70 mothers and 50 fathers) aged be-tween 27 and 56 years (M = 38.84; SD = 5.03). Questionnaires were administered on sociodemo-graphic and behavioral data of the children, as well as a brief scale to assess parenting. Mann Whitney U and MANOVA were used to analyze the influence of gender on perceived changes in children's behavior and perceived parenting, respectively. Mothers perceived more significant changes than fathers in their children's behavior. In addition, women reported more parental stress, greater child school sup-port, and greater perceived positive parenting, compared to men. These findings support the hypothesis that parenting developed differently in fathers and mothers which is likely influenced by culture.
The Lavatory Lens: Tracking the Global Movement of Pathogens via Aircraft Wastewater
Authors: Bivins Aaron , Morfino Robert , Franklin Andrew , Simpson Stu , Ahmed Warish
Published: May 2023

Modern commercial air travel connects disparate human populations with the global airline industry transporting up to 4.5 billion passengers annually in the years leading up to the COVID-19 pandemic. While such connections are convenient for commerce and tourism, air travel networks can also be efficient distributors of infectious diseases such as influenza, SARS-CoV-1, hemorrhagic fevers, and more recently SARS-CoV-2 and monkeypox. During the COVID-19 pandemic, public health agencies used multi-layered control strategies including pre-departure testing and vaccination requirements, masking, post-arrival testing, and quarantine to manage the risk of COVID-19 transmission associated with air travel. Simultaneously, the surveillance of aircraft wastewater emerged as a promising new data source to screen for SARS-CoV-2 infections, including newly emergent lineages, among international air travelers. Herein, we review the potential of aircraft wastewater for public health surveillance. The known contributing population and flight itinerary combined with the highly concentrated waste stream and convenient sampling during routine lavatory servicing make aircraft wastewater a strategic opportunity for unintrusive surveillance of the global fluxes of human pathogens. We estimate for the cases of fecal- or urine-shed pathogens, sampling from 3,500 and 1,250 flights per week, respectively, would be required to survey 10% of all global long-haul flight passengers. In the case of the United States, achieving 10% coverage of all international arrivals would require sampling from 925 and 322 flights per week, respectively. Aircraft wastewater surveillance could also be integrated with network and infectious disease models to better inform traditional public health control measures during emerging epidemics. Given the tremendous potential for public good and the massive economic costs of epidemics, governments should consider international collaboration to create a global aircraft wastewater surveillance system.
Local Stability and Bifurcation Analysis of Onchocerciasis Transmission Dynamics With Nonlinear Incidence Functions in Two Interacting Populations
Authors: Adeyemo Kabiru Michael
Published: May 2023

A deterministic compartment model for the transmission dynamics of onchocerciasis with nonlinear incidence functions in two interacting populations is studied. The model is quantitatively analyzed to investigate it's local asymptotic behavior with respect to disease-free and endemic equilibria. It is shown, using Routh-Hurwitz criteria, that the disease-free equilibrium is locally asymptotically stable when the basic reproduction number is less than the unity. When the reproduction number is greater than the unity, we prove the existence of a locally asymptotically stable endemic equilibrium. Furthermore, bifurcation analysis was done by investigating the possibility of the co-existence of the equilibria of the model at R0<0 but near R0=0 by Center Manifold Theory.
Triplet Superconducting Correlations in Hybrid Superconducting Junctions
Authors: Constantinian Karen , Ovsyannikov Gennady , Petrzhik Andrey , Kislinskii Yulii
Published: May 2023

We summarize the results on electron transport in hybrid superconducting S/B/S' mesa-structure consisted of the oxide epitaxial S/B heterostructures, where S is the cuprate YBa2Cu3O 7-x superconductor, B – an interlayer with the spin dependent characteristics, and S’ is the Nb top superconductor. Josephson effect was observed manifested in appearance of oscillating Shapiro steps amplitudes with microwave signal power due to synchronization of junction self-generation of electromagnetic radiation and the external microwave probe signal. Triplet component of superconducting correlations emerged when the interlayer comprised two magnetic materials SrRuO3 and La0.7Sr0.3MnO3 with non-collinear magnetizations as well in the case of antiferromagnetic insulator Sr2IrO4 characterized by strong spin-orbit interaction. Thickness of the interlayer in the both cases considerably exceeded the coherence length of the magnetic spin active interlayer hinting on appearance of long-range proximity effect and spin-triplet superconducting current. Magnetic field dependences measured at dc, and the existence of the second harmonic in superconducting current–phase relation revealed by measurements at microwave frequencies will be discussed.
The Pathophysiological Changes and Clinical Effects of Tetramethylpyrazine in ICR Mice with Fluoride-Induced Hepatopathy
Authors: Zhang Shuai , Zheng Yilei , Du Hong , Zhang Wei , Li Haohuan , Ou Yangping , Xu Funeng , Lin Juchun , Fu Hualin , Zhang Liren , Shu Gang
Published: May 2023

Excessive intake of fluoride, one of the trace elements to maintain health, leads to liver injury. Tetramethylpyrazine (TMP) is a kind of traditional Chinese medicine monomer with good antioxidant and hepatoprotective function. The aim of this study was to investigate the effect of TMP on liver injury induced by acute fluorosis. A total of 60 1-month-old male Institute of Cancer Research mice without carriage of pathogenic bacteria were selected. All mice were fed adaptively for one week, and then randomly divided into 5 groups: control (K) group, model (F) group, low-dose (LT) group, medium-dose (MT) group and high-dose (HT) group. The control and model group were given distilled water, while 40 mg/kg (LT), 80 mg/kg (MT) and 160 mg/kg (HT) TMP were fed by gavage for two weeks with the maximum gavage volume of mice is 0.2ml/10g/d. Except for the control group, all groups were given fluoride (35 mg/kg) by intraperitoneal injection on the last day of the experiment. The results of this study showed that compared with the model group, TMP alleviated the pathological changes of liver induced by fluoride and improved the ultrastructure of liver cells; TMP significantly decreased the levels of ALT, AST and MDA (P <0.05), and increased the levels of T-AOC, T-SOD and GSH (P <0.05). The results of mRNA detection showed that TMP significantly increased the mRNA expression levels of Nrf2, HO-1, CAT, GSH-Px and SOD in liver compared with model group (P <0.05). In conclusion, TMP can inhibit oxidative stress by activating Nrf2 pathway and alleviate liver injury induced by fluoride.
Zeylleucapenoids A-D, Highly Oxygenated Diterpenoids with Anti-inflammatory Activity from Leucas zeylanica
Authors: Zhao Ting , Zhang Xuan , Nong Xu-Hua , Zhou Xue-Ming , Chai Ru-Ru , Li Xiao-Bao , Chen Guang-Ying
Published: May 2023

Four previously undescribed highly oxygenated diterpenoids (1–4), zeylleucapenoids A–D, characterized by halimane and labdane skeletons, were isolated from the aerial parts of Leucas zeylanica. Their structures were elucidated primarily by NMR experiments. The absolute configuration of 1 was established by theoretical ECD calculations and X-ray crystallographic analysis, whereas those for 2−4 were assigned by theoretical ORD calculations. Zeylleucapenoid D (4), with an IC50 value of 38.45 μM in RAW264.7 macrophages and nontoxic activity for zebrafish embryo, and obviously inhibited pro-inflammatory cytokines TNF-α and IL-6 in a dose-dependent manner. Compound 4 inhibited of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, molecular docking analysis indicated the possible mechanism of action for 4 may be bind to targets by hydrogen- and hydrophobic- bond interactions.
Influence of Removing Leaf Node Neighbors on Network Controllability
Authors: Li Junli , Wu Chengpei , Xu Siyi , Yu Zhuoran
Published: May 2023

From the perspective of network attackers, finding attack sequences that can make significant damage on network controllability is an important task, which also helps defenders improve the robustness during network constructions. Therefore, developing effective attack strategies is a key aspect of research on network controllability and its robustness. In this paper, we propose a Leaf Node Neighbor-based Attack (LNNA) strategy that can effectively disrupt the controllability of undirected networks. The LNNA strategy targets the neighbors of leaf nodes, and when there are no leaf nodes in the network, the strategy attacks the neighbors of nodes with a higher degree to produce the leaf nodes. Results from simulations on synthetic and real-world networks demonstrate the effectiveness of the proposed method. In particular, our findings suggest that removing neighbors of low-degree nodes (i.e., nodes with degree 1 or 2) can significantly reduce the controllability robustness of networks. Thus, protecting such low-degree nodes and their neighbors during network construction can lead to networks with improved controllability robustness.
Pyrolytic Graphite for In-Plane Force Study of Diamagnetic Levi-Tation: A Potential Magnetic Material Cracks Micro-Detector
Authors: Liu Runze , Yang Wenjiang , Xiang Hongjun , Zhao Peng , Deng Fuwen , Yan Juzhuang
Published: May 2023

The diamagnetic levitation technique can be applied to non-destructive testing for identifying cracks and defects in magnetic materials. Pyrolytic graphite is a material that can be leveraged in micromachines due to its no-power diamagnetic levitation on a permanent magnet (PM) array. However, the damping force applied to pyrolytic graphite prevents it from maintaining con-tinuous motion along the PM array. This paper investigates the in-plane motion and damping characteristics of pyrolytic graphite sheets on the PM array. The centroid of pyrolytic graphite will maintain a stable levitation when positioned on the intersecting point of the PM array. Fur-thermore, the in-plane motion of two different pyrolytic graphite sizes - PG10 (10×10×0.5mm3) and PG20 (20×20×0.5mm3) - has revealed that the in-plane forces applied to them are approximately 61.4μN and 28.2μN, respectively. The smaller sheet has a shorter oscillation time while oscillating before it stabilizes. The damping ratio of the oscillation was between 0.1-0.2. The in-plane force and the stable time of pyrolytic graphite are related to its size ratio in comparison with the PM. This relationship is believed to promote stability, as the force acting on the graphite sheet will be distributed over a larger area when the sheet size increases. During the fixed-axis rotation process, the study found that the friction coefficient and friction force decreased as the rotational speed decreased. The diamagnetic levitation of pyrolytic diamagnetic levitation is also unable to maintain long-term axial rotation. Finally, friction force was tested using PG10 during fixed-axis rotation above a circular PM array. The results showed that the order of the friction coefficient is 10-3, and the friction force is about 0.8μN, decreasing with graphite rotation speed. We hope this technique will be used in crack detection, magnetic detection and other micromachine.
Advanced Numerical Methods for Graphene Simulation With Equivalent Boundary Conditions: A Review
Authors: Gong Yansheng , Liu Na
Published: May 2023

Since the discovery of graphene, due to its excellent optical, thermal, mechanical and electrical properties, it has a broad application prospect in energy, materials, biomedicine, electromagnetism and other fields. A great quantity of researches on the physical mechanism of graphene has been applied to engineering in electromagnetism and optics. To study the properties of graphene, different kinds of numerical methods have been developed for simulating the electromagnetic field effects of graphene, and equivalent boundary conditions have been employed to replace graphene in the computational domain. In this work, the numerical methods with equivalent boundary conditions are reviewed, and some examples are provided to illustrate their applicability.
Pengembangan Media Pembelajaran Interaktif Sistem Tata Surya untuk Siswa Kelas 6 Sekolah Dasar
Authors: Efrianto Delvia Nova , Famukhit Muga Linggar , Rahayu Dwi
Published: May 2023

This study aims to develop learning media for the solar system using Adobe Flash to support the learning process of students at SDN 1 Hadiluwih, help foster interest in learning the solar system through teaching aids that are more attractive and easy to understand, implement learning media based on solar systems. Interactive Adobe Flash. The research method used in this research is the method of research and development (Research & Development). The data collection method used a questionnaire method with the research subjects of grade 6 elementary school students. Processing the questionnaire method with a Likert scale. The data analysis technique uses the help of the Microsoft Excel program. Based on the research results, it can be seen that students are greatly helped in learning the Solar System using interactive learning media. Students are helped in studying the material of the solar system because there are videos, pictures, quizzes, and writing that are easy to understand.
Pola Asuh Orang Tua dan Implikasinya terhadap Prestasi Akademik Siswa Sekolah Dasar Yang Berkegiatan di TPA Alba
Authors: Fitria Heni , Burhanuddin Afid , Purnamasari Mega Isvandiana
Published: May 2023

This study aims to determine: (1) the parenting parents elementary school students who study in TPA ALBA, (2) the implication of parenting parents elementary school students who study at TPA ALBA toward academic achievement of students.This research is a qualitative descriptive study using 6 subjects selected by purposive sampling on students who study at TPA ALBA. The object of this study is parenting and its implications for students’ academic achievement. Data collection techniques used observation, interviews, and documentation. Data analysis used in this research was data reduction, data display, and conclusion drawing.The result of the data analysis can be concluded that: (1) Parenting style with authoritative type has a positive impact on children’s development. (2) Parenting style with authoritative type becomes a factor as an improvement student’s academic achievement.
Conocimientos actuales sobre Trypanosoma cruzi y la enfermedad de Chagas en México: una revisión sistemática
Authors: Bravo-Ramírez Iván E. , Pech-May Angelica , May-Concha Irving Jesús , Ramsey Janine M.
Published: May 2023

Objetivo. Sistematizar, evaluar y sintetizar la investigación original específica en México sobre la zoonosis por Trypano-soma cruzi, los vectores (Triatominae: Hemiptera: Reduviidae) y la enfermedad de Chagas (EC). Material y métodos. La investigación original fue identificada con PRISMA mediante cuatro sistemas de búsqueda, usando criterios de inclusión, se realizó la asignación a 14 áreas temáticas y fue evaluada mediante criterios técnicos. Resultados. De un total de 1 410 registros, fueron elegidos 659 (46.7%) para la valoración técnica, de los cuales, 221 (15.7%) fueron incluidos como las evidencias de mayor calidad. El buscador PubMed contribuyó con 95% de los registros, mientras que los buscadores BibTri, Lilacs y Scielo aportaron 5%. La tasa de publicación fue constante de 1950 a 1990, con un incremento exponencial de 1995 a 2020. La alta calidad de publicaciones incrementó de 5.3% en 1990 hasta 49.8% en 2020. Los temas de aspectos sistémicos, económicos, antropológicos y sociales de la EC en México fueron los menos representados (8%). Conclusiones. En las dos últimas décadas en México ha incrementado la investigación científica. Sin embargo, son notables las caren- cias en las áreas para poder fundamentar la política pública sanitaria en cuanto a la atención, la prevención y el control de la EC en el país.
Trabajadoras comunitarias de salud: experiencias en el abordaje de la salud mental en zonas rurales de Chiapas
Authors: González-Robledo María Cecilia , Gonzalez-Robledo Luz Maria , Nudel-Ontiveros Alejandra , Agudelo-Botero Marcela , Rodríguez-Cuevas Fátima Gabriela , Reyes-Morales Hortensia
Published: May 2023

Objetivo. Analizar, desde la perspectiva de las trabajadoras comunitarias de salud (TCS), los conocimientos y experiencias en la atención de la salud mental (SM) en comunidades rurales de Chiapas. Material y métodos. Se utilizó el enfoque fenomenológico descriptivo. Se realizaron 18 entrevistas semiestructuradas a TCS, las cuales fueron audiograbadas, transcritas, codificadas y analizadas utilizando como técnica, el análisis cualitativo de contenido con ayuda del software Atlas ti. Resultados. Las TCS mental tienen una amplia comprensión de la cultura, el lenguaje y los problemas de sus comunidades, permitiéndoles fungir como enlace entre los servicios de salud y la población. Identifican que hay buena SM cuando “una persona tiene ánimo de realizar su trabajo diario” y enfermedad cuando “las personas sufren o tienen pensamientos chuecos”. Sus experiencias de trabajo están ligadas con el acompañamiento individual (psico-educación) y el apoyo de actividades realizadas por profesionales de Compañeros En Salud (CES). Conclusión. Las TCS mental que trabajan con CES desarrollan un papel importante en la promoción de la SM, de riesgos y acompañamiento de pacientes con trastornos mentales. Estos hallazgos consolidan la evidencia e importancia del desarrollo de las intervenciones comunitarias en SM a través de este personal, en contextos de escasa disponibilidad de servicios de salud.
Evidencia molecular de Rickettsia ricketsii y Rickettsia felis en garrapatas colectadas en ganado bovino en la costa de Chiapas
Authors: Danis-Lozano Rogelio , Camacho-Ramírez Susana , Álvarez-Hernández Gerardo , Leyva-Gastelum Marcia , Cisneros-Vásquez Luis Alberto , Dzul-Rosado Karla R , Fernández-Salas Ildefonso , López-Ordoñez Teresa
Published: May 2023

Objetivo. Estimar la diversidad de garrapatas, la prevalencia de infestación y tasa de infección de Rickettsia spp. en ganado bovino en la costa del estado de Chiapas. Material y métodos. Se realizó un estudio transversal de octubre de 2021 a marzo de 2022, que incluyó la extracción de garrapatas de 297 vacas pertenecientes a 5 municipios. Se calcularon los índices de diversidad. El diagnóstico de Rickettsia spp en las garrapatas se realizó mediante PCR anida. Resultados. Se encontró una baja diversidad de especies. Las especies Rhipicephalus microplus, Amblyomma cajennense y Rhipicephalus sanguineus hembra adultas fueron positivas a Rickettsia spp. Los municipios de Pijijiapan y Tonalá presentaron la TMI más alta con 7.5 y 7.2%. Conclusión. Este es primer estudio México que reporta infección de Rickettsia spp, en garrapatas colectadas de ganado bovino, lo cual indica un riesgo de salud pública.
State-level prevalence of anemia in women of reproductive age. Ensanut 2006, 2012 and 2018-19
Authors: Mejía-Rodríguez Fabiola , Shamah-Levy Teresa , Méndez Gómez-Humarán Ignacio , Villalpando Salvador
Published: May 2023

Objective. To compare the prevalence of anemia and iron deficiency, at state level in non-pregnant women between 20 and 49 years of age from the Encuesta Nacional de Salud y Nutrición (Ensanut, in Spanish) 2006, 2012 and 2018-19. Materials and methods. The Ensanut 2006, 2012 and 2018-19 have a probabilistic design. Hb in capillary blood was measured by HemoCue Hb201 and ferritin by venous sample. Anemia was diagnosed with Hb<120g/L and iron deficiency with Ferritin<15ng/mL. Results. At the national level, anemia increased 6.1 (p<0.05) percentage points (pp) from 2006 to 2018-19. Baja California Norte, Campeche, Colima, Chiapas, Quintana Roo, Sinaloa and Sonora, went from low prevalence (5 to 19.9%) to moderate (20 to 39.9%); in Yucatán and Tamaulipas it went from low to severe (>40). In Guanajuato, State of Mexico and Querétaro it was reduced from 2006 to 2018-19 (p<0.05). Conclusions. Anemia continues to be a public health problem that requires actions at the state level, considering level of wellbeing index, food programs and affiliation to medical Services insurance.
Formando talento humano en salud durante la postpandemia
Authors: Perelman Carol
Published: May 2023

Uno de los tantos pendientes que la pandemia porCovid-19 exhibió es la necesidad de reflexionarsobre los retos en la formación de quienes, en un futuro,trabajarán por la salud, es decir, (...)
Prediction of Casing Collapse Resistance by 3D Finite Element Modeling
Authors: Lin Bisen , Coe David , Harris Richard , Klever Frans
Published: May 2023

3D outside diameter (OD) and wall thickness mapping of a casing joint consists of synchronized OD laser scanning and ultrasonic testing (UT) wall thickness measurement at a resolution of every 1 in. along the length and every 1° or 2° around the circumference. This full-length mapping data can then be used to construct a 3D finite element analysis (FEA) model that captures the geometric attributes, including OD, wall thickness, OD ovality, and wall eccentricity, of a casing joint. Together with the actual nonlinear material plasticity model and the measured as-manufactured residual stress, the 3D FEA model can predict the casing collapse strength with good accuracy. Also, the Klever-Tamano ultimate limit-state (KT ULS) collapse equation per API TR 5C3 (2018) together with a moving-average (MA) scheme can calculate the joint’s collapse strength.

Results predicted by 3D FEA and KT ULS collapse models are compared to the actual full-scale collapse test results. A 3D FEA model generally produces more accurate results than the KT collapse equation. In addition, both 3D FEA and KT collapse models predict a collapse pressure slightly lower than the actual collapse pressure, which is therefore on the conservative side.

The prediction of casing collapse strength can be beneficial to the end user in sorting and ranking the casing joints by collapse resistance, and therefore provides valuable information that can be used in the end user’s risk assessment. Furthermore, the end user may potentially select the joints with the highest predicted collapse strength for the portion of the casing string where the highest collapse resistance is desired.

In addition, the OD and wall mapping data together with the actual material tensile properties (yield strength, ultimate tensile strength, and strain hardening parameters) can be used in estimating the internal yield, ductile rupture pressures, and other performance properties. This is outside the scope of this paper and can be pursued in future work. These predicted casing performance properties may then be used in sorting and ranking the joints based on a specific performance property of interest or a combination of performance properties.
Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells
Authors: Rifes Pedro , Isaksson Marc , Rusimbi Charlotte , Santoja Adrian Ramón , Wahlestedt Jenny Nelander , Laurell Thomas , Kirkeby Agnete
Published: May 2023

Background:Ventral midbrain (VM) dopaminergic progenitor cells derived from human pluripotent stem cells have the potential to replace endogenously lost dopamine neurons and are currently in preclinical and clinical development for treatment of Parkinson’s Disease (PD). However, one main challenge in the quality control of the cells is that rostral and caudal VM progenitors are extremely similar transcriptionally though only the caudal VM cells give rise to dopaminergic (DA) neurons with functionality relevant for cell replacement in PD. Therefore, it is critical to develop assays which can rapidly and reliably discriminate rostral from caudal VM cells during clinical manufacturing.Methods:We performed shotgun proteomics on cell culture supernatants from rostral and caudal VM progenitor cells to search for novel secreted biomarkers specific to DA progenitors from the caudal VM. Key hits were validated by qRT-PCR and ELISA.Results:We identified and validated several novel secreted markers significantly enriched in caudal VM progenitor cultures (CPE, LGI1 and PDGFC), and found that these markers correlated strongly with the intracellular expression ofEN1, which is a predictive marker for successful graft outcome in DA cell transplantation products. Other markers (CNTN2 and CORIN) were found to be significantly enriched in the non-dopaminergic rostral VM cultures. Key novel ELISA markers were further validated on supernatant samples from GMP-manufactured caudal VM batches.Conclusion:We propose a panel of coupled ELISA assays that can be applied as non-invasive quality control tests for validating correct patterning of caudal VM DA cells during clinical manufacturing.
The association between sarcopenia and incident of depressive symptoms: A prospective cohort study
Authors: Li Zhenzhen , Liu Bingqing , Tong Xiang , Ma Yao , Bao Ting , Wu Chenkai , Yue Jirong
Published: May 2023

Background Epidemiological studies have shown that sarcopenia was associated with depression among older adults. However, most of these investigations used a cross-sectional design, limiting the ability to establish a causal relation, the present study examined whether sarcopenia was associated with incident depressive symptoms.Methods This is a prospective cohort study with participants from the Western China Health and Aging Trends (WCHAT) study. Participants could complete anthropometric measurements and questionnaires were included. The exposure was sarcopenia, defined according to the Asian Working Group for Sarcopenia in 2019, the outcome was depressive symptoms, evaluated by GDS-15. We excluded depression and depressive symptoms at baseline and calculated the risk of incident depressive symptoms during the follow-up year.Results A total of 2612 participants (mean age of 62.14 ± 8.08 years) were included, of which 493 with sarcopenia. 78 (15.82%) participants with sarcopenia had onset depressive symptoms within the next year. After multivariable adjustment, sarcopenia increased the risk of depressive symptoms (RR = 1.651, 95%CI = 1.087–2.507, P = 0.0187) in overall participants. Such relationship still exists in gender and sarcopenia severity subgroups. Low muscle mass increased the risk of depressive symptoms (RR = 1.600, 95%CI = 1.150–2.228, P = 0.0053), but low muscle strength had no effect (RR = 1.250, 95%CI = 0.946–1.653, P = 0.117).Conclusions Sarcopenia is an independent risk factor for depressive symptoms, Precautions to early detect and targeted intervene for sarcopenia should continue to be employed in adult with sarcopenia to achieve early prevention for depression and reduce the incidence of adverse clinical outcomes.
Omicron-Specific and Bivalent Omicron-Containing Vaccine Candidates Elicit Potent Virus Neutralisation in the Animal Model
Authors: Abdoli Asghar , Jamshidi Hamidreza , Taqavian Mohammad , Baghal Mehdi Lari , Jalili Hasan
Published: May 2023

Omicron variant (B.1.1.529) is able to escape from naturally acquired and vaccine-induced immunity, which mandates updating the current COVID-19 vaccines. Here, we investigated and compared the neutralising antibody induction of the ancestral variant-based BIV1-CovIran vaccine, the Omicron variant-based BIV1-CovIran Plus vaccine, and the novel bivalent vaccine candidate, BBIV1-CovIran, against the Omicron and ancestral Wuhan variants on the rat model. After inactivating the viral particles, the viruses were purified and formulated. Bivalent vaccines were a composition of 2.5 micrograms (5 micrograms total) or 5 micrograms (10 micrograms total) doses of each ansectral-based and Omicron-based monovalent vaccine. Subsequently, the potency of the monovalent and bivalent vaccines was investigated using the virus neutralisation test (VNT). The group that received three doses of the Omicron-specific vaccine demonstrated neutralisation activity against the Omicron variant with a geometric mean titer of 337.8. However, three doses of the Wuhan variant-specific vaccine could neutralise the Omicron variant at a maximum of 1/32 serum dilution. The neutralisation activity of the Omicron-specific vaccine, when administered as the booster dose after two doses of the Wuhan variant-specific vaccine, was 100% against the Omicron variant and the Wuhan variant at 1/64 and 1/128 serum dilution, respectively. Three doses of 5 micrograms bivalent vaccine could effectively neutralise both variants at the minimum of 1/128 serum dilution. The 10 micrograms bivalent vaccine at three doses showed even higher neutralisation titers: geometric mean titer of 338.0 against Omicron and 445.7 against Wuhan). It is shown that the candidate bivalent and Omicron-specific vaccines could elicit a potent immune response against both Wuhan-Hu-1 and Omicron BA.1 variants.
Sulindac inhibits the proliferation and promotes apoptosis of laryngeal cancer cells by down-regulating the AKT/β-catenin pathway
Authors: Bian Jiawei , Zhou Yulin , Zhu Wanglong , Ma Keyi , Chen Jia , Huang Shi , Huang Chaoping , Fan Jiangang , Wu Jiaqing , Chen Lan , Nie Lei , Meng Lianyi , Song Minjie , Yang Yuhan , Wang Yi , Zhang Kun
Published: May 2023

Background: Laryngeal cancer is one of the most common tumors in the head and neck. Uncertainty of targets, mechanisms, and lack of effective drugs largely limit laryngeal cancer prevention and clinical treatment. Therefore, there is an urgent need to develop new drug candidates to prevent and treat laryngeal cancer.
Methods: In this study, laryngeal cancer Tu212 and Tu686 cells were treated with different concentrations of sulindac, and their effects on the proliferation, cell cycle, and apoptosis of laryngeal cancer cells were detected by CCK-8, clone formation assay, and flow cytometry; Western-blot was used to detect the effects of sulindac on proliferation and apoptosis-related proteins.
Results: Sulindac can dose-dependently block the G1/S phase of the laryngeal cancer Tu686 and Tu212 cell cycle to inhibit cell proliferation and significantly induce laryngeal cancer cell apoptosis. Besides, Western blotting also confirmed that the relative expressions of cell cycle-related proteins CyclinD1 and c-Myc were down-regulated; apoptosis-related proteins Bcl-2, Caspase-3, and Survivin were down-regulated, Bax and Cleaved caspase-3 were up-regulated. In addition, sulindac can down-regulate the expression of p-Akt and β-catenin.
Conclusion: Our study found that sulindac can inhibit the proliferation of laryngeal cancer cells and induce apoptosis by down-regulating the expression of the AKT/β-catenin pathway. Research on the anti-laryngeal cancer properties of sulindac is still very scarce. Our research provides an important theoretical basis for the clinical application of sulindac in the prevention and treatment of laryngeal cancer.