bluuebunny/crossref_metadata_2025 huggingface dataset:
Tailoring the gas separation efficiency of metal organic framework ZIF-8 through metal substitution: a computational study
Authors: Krokidas Panagiotis , Moncho Salvador , Brothers Edward N. , Castier Marcelo , Economou Ioannis G.
Published: January 2018

The influence of a zeolitic imidazolate framework (ZIF)'s metal identity on its gas separation performance is studied extensively through molecular simulations for a variety of gases.
Catalytic (de)hydrogenation promoted by non-precious metals – Co, Fe and Mn: recent advances in an emerging field
Authors: Filonenko Georgy A. , van Putten Robbert , Hensen Emiel J. M. , Pidko Evgeny A.
Published: January 2018

This review is aimed at introducing the remarkable progress made in the last three years in the development of base metal catalysts for hydrogenations and dehydrogenative transformations.
Towards the continuous production of Pt-based heterogeneous catalysts using microfluidic systems
Authors: Laura Uson , Arruebo Manuel , Sebastian Victor
Published: January 2018

The continuous production of Pt-based heterogeneous catalysts based on ultra-small (<2 nm) noble metal nanoparticles deposited on mesoporous ordered silica and their catalytic activity in VOC abatement are here reported. Commercially available micromixers can be easily interfaced to create a multistage platform which allows the growth of metal noble NPs as well as their alloys.
Metal–organic frameworks based on octafluorobiphenyl-4,4′-dicarboxylate: synthesis, crystal structure, and surface functionality
Authors: Cheplakova Anastasia M. , Kovalenko Konstantin A. , Samsonenko Denis G. , Lazarenko Vladimir A. , Khrustalev Victor N. , Vinogradov Andrey S. , Karpov Victor M. , Platonov Vyacheslav E. , Fedin Vladimir P.
Published: January 2018

Six Zn coordination polymers have been synthesized and investigated in terms of their surface properties.
A yolk–shell V2O5 structure assembled from ultrathin nanosheets and coralline-shaped carbon as advanced electrodes for a high-performance asymmetric supercapacitor
Authors: Xing Ling-Li , Zhao Gang-Gang , Huang Ke-Jing , Wu Xu
Published: January 2018

Various V2O5 three-dimensional nanostructures are synthesized using a facile template-free hydrothermal method and evaluated for use as supercapacitor electrode materials.
Metabolism, survival, and gene expression ofPseudomonas putidato hematite nanoparticles mediated by surface-bound humic acid
Authors: Ouyang Kai , Walker Sharon L. , Yu Xiao-Ying , Gao Chun-Hui , Huang Qiaoyun , Cai Peng
Published: January 2018

This work serves as a platform to better understand the interactions between bacteria/biofilms and minerals in the natural environment.
Physicochemical properties of air discharge-generated manganese oxide nanoparticles: comparison to welding fumes
Authors: Stebounova Larissa V. , Gonzalez-Pech Natalia I. , Peters Thomas M. , Grassian Vicki H.
Published: January 2018

Physicochemical properties of manganese nanoparticles are key to adverse health effects.
The effects of whey and soy proteins on growth performance, gastrointestinal digestion, and selected physiological responses in rats
Authors: Wróblewska B. , Juśkiewicz J. , Kroplewski B. , Jurgoński A. , Wasilewska E. , Złotkowska D. , Markiewicz L.
Published: January 2018

The objective of this work was to identify the nutritional and physiological effects of commercial soy and whey protein preparations.
Total reflection X-ray fluorescence based quantification of gold nanoparticles in cancer cells
Authors: Mankovskii Gabriella , Pejović-Milić Ana
Published: January 2018

A small (5 μl) sample volume and minimal sample preparation steps are required to accurately quantify AuNP uptake in cancer cells.
Production of monodisperse drops from viscous fluids
Authors: Håti Armend G. , Szymborski Tomasz R. , Steinacher Mathias , Amstad Esther
Published: January 2018

We present a microfluidic device containing parallelized triangular nozzles with rectangular cross-sections and demonstrate that its throughput can be significantly increased if each nozzle is intersected by shunt channels that facilitate the flow of the continuous phase into the nozzle.
Azasilicon-bridged heterocyclic arylamines: syntheses, structures and photophysical properties
Authors: Yuan Shifang , Wang Lijing , Huang Chuanbing , Niu Chunxia , Xiang Kai , Xu Caihong , Solan Gregory A. , Ma Hongwei , Sun Wen-Hua
Published: January 2018

The lithium κ1-enamides undergo intermolecular cyclization reactions affording bis-azasilicon-bridged heterocyclic arylamines, which were hydrolysed to the saturated 1,4-diimines, and alternatively proceeded a redox reaction to afford the conjugated 1,4-diimines.
A simple dispersive-micro-solid phase extraction based on a colloidal silica sorbent for the spectrophotometric determination of Fe(ii) in the presence of tetrabutylammonium bromide
Authors: Metarwiwinit S. , Mukdasai S. , Poonsawat C. , Srijaranai S.
Published: January 2018

This study demonstrates a simplified dispersive micro-solid phase extraction (d-μ-SPE) using silica sol as the sorbent for the preconcentration of ferrous ions.
De-bundled single-walled carbon nanotube-modified sensors for simultaneous differential pulse voltammetric determination of ascorbic acid, dopamine, and uric acid
Authors: Thirumalai Dinakaran , Subramani Devaraju , Yoon Jang-Hee , Lee Jaewon , Paik Hyun-jong , Chang Seung-Cheol
Published: January 2018

De-bundled SWCNTs modified glassy carbon electrode for the simultaneous differential pulse voltammetric determination of ascorbic acid, dopamine, and uric acid.
Titania nanowires coated PEI/P25 membranes for photocatalytic and ultrafiltration applications
Authors: Jiang Rui , Wen Wei , Wu Jin-Ming
Published: January 2018

Bulk compositing and surface functionalization are combined to achieve a polymeric membrane that is covered with TiO2 nanowires, which possesses multi-functions of photodegradation, separation and self-cleaning.
o-Iodoxybenzoic acid mediated generation of aryl free radicals: synthesis of stilbenes through C–C cross-coupling with β-nitrostyrenes
Authors: Wagh Ganesh , Autade Snehalata , Patil Pravin C. , Akamanchi Krishnacharya G.
Published: January 2018

The generation of an aryl free radicals in the presence of nitrostyrenes through a combination of aryl hydrazines and o-iodoxybenzoic acid led to the synthesis of stilbenes by forming a new carbon–carbon bond after subsequent elimination of a nitrosyl radical.
Plasmonic nanoparticles embedded in single crystals synthesized by gold ion implantation for enhanced optical nonlinearity and efficient Q-switched lasing
Authors: Nie W. J. , Zhang Y. X. , Yu H. H. , Li R. , He R. Y. , Dong N. N. , Wang J. , Hübner R. , Böttger R. , Zhou S. Q. , Amekura H. , Chen F.
Published: January 2018

We report on the synthesis of embedded gold (Au) nanoparticles (NPs) in Nd:YAG single crystals using ion implantation and subsequent thermal annealing.
Phase engineering of seamless heterophase homojunctions with co-existing 3R and 2H phases in WS2 monolayers
Authors: Kumar Pawan , Verma Navneet Chandra , Goyal Natasha , Biswas Jayeeta , Lodha Saurabh , Nandi Chayan K. , Balakrishnan Viswanath
Published: January 2018

The formation of in-plane homojunctions (3R–2H) with co-existing phases shows variations in luminescence properties, fluorescence lifetime and work function across a seamless boundary in CVD-grown WS2 monolayers.
E–Z isomerization in Suzuki cross-couplings of haloenones: ligand effects and evidence for a separate catalytic cycle
Authors: Chehal Navneet K. , Budzelaar Peter H. M. , Hultin Philip G.
Published: January 2018

We present evidence for a palladocyclic enolate-like pathway for isomerization of enones occurring during Suzuki cross-coupling reactions.
Crystal structures, phase transitions and thermal expansion properties of NaZr2(PO4)3–SrZr4(PO4)6 solid solutions
Authors: Liu Ying , Molokeev Maxim S. , Liu Quanlin , Xia Zhiguo
Published: January 2018

Structures and phase transitions depending on compositions and temperature between R3̄c and R3̄ in Na(2−2x)Srx[ ]xZr4(PO4)6 have been investigated.
Integration of aligned polymer nanofibers within a microfluidic chip for efficient capture and rapid release of circulating tumor cells
Authors: Xiao Yunchao , Wang Mengyuan , Lin Lizhou , Du Lianfang , Shen Mingwu , Shi Xiangyang
Published: January 2018

Zwitterion-functionalized aligned nanofibers integrated with a microfluidic chip can be used for highly efficient capture and rapid release of CTCs.
Rhodium-mediated enantioselective synthesis of a benzopicene-based phospha[9]helicene: the structure–property relationship of triphenylene- and benzopicene-based carbo- and phosphahelicenes
Authors: Nishigaki Shuhei , Murayama Koichi , Shibata Yu , Tanaka Ken
Published: January 2018

The enantioselective synthesis of a phospha[9]helicene with a bibenzopicene skeleton has been achievedviathe rhodium-mediated intermolecular [2+2+2] cycloaddition of a binaphthyl-linked tetrayne with a phosphorus-linked diyne.
Rh(iii)-Catalyzed regio- and stereoselective bisindolylation of vinyl acetate: an efficient approach toward (E)-1,2-bis(2-indolyl)ethenes
Authors: Qin Wen-Bing , Li Wei-Wei , Zhu Peng-Fei , Mo Xiao-Gang , Zhang Hui-Jun , Wen Ting-Bin
Published: January 2018

An efficient Rh(iii)-catalyzed regio- and stereoselective cross-coupling between vinyl acetate andN-(2-pyridiyl)indoles providing a series of (E)-2,2′-bis(indolyl)ethenes has been developed.
Improvement of O2 adsorption for α-MnO2 as an oxygen reduction catalyst by Zr4+ doping
Authors: Wang Yicheng , Li Yaozong , Lu Zhenghang , Wang Wei
Published: January 2018

O2 adsorption was enhanced after doping Zr4+ into MnO2 nanowires subsequently led to the improvement of ORR catalytic performance.
Tunable actuation behavior of ionic polymer metal composite utilizing carboxylated carbon nanotube-doped Nafion matrix
Authors: Ru Jie , Zhu Zicai , Wang Yanjie , Chen Hualing , Li Dichen
Published: January 2018

In this study, we propose to neutralize the relaxation deformation of Nafion-ionic polymer metal composite (IPMC) by slow anode deformation of Flemion-IPMC caused by carboxyl groups (–COOH).
Activated carbons modified by magnesium oxide as highly efficient sorbents for acetone
Authors: Zhou Ke , Li Liqing , Ma Xiancheng , Mo Yamian , Chen Ruofei , Li Hailong , Li Haoyang
Published: January 2018

Porous activated carbon modified with MgO was synthesized by an evaporation-induced self-assembly (EISA) method for its application to acetone capture.
Correction: Rhodium-catalyzed cycloaddition of carbonyl ylides for the synthesis of spiro[furo[2,3-a]xanthene-2,3′-indolin]-2′-one scaffolds
Authors: Subba Reddy B. V. , Pravardhan Reddy E. , Sridhar B. , Jayaprakash Rao Y.
Published: January 2018

Correction for ‘Rhodium-catalyzed cycloaddition of carbonyl ylides for the synthesis of spiro[furo[2,3-a]xanthene-2,3′-indolin]-2′-one scaffolds’ by B. V. Subba Reddy et al., RSC Adv., 2016, 6, 50497–50499.
Correction: Extremely low coercivity in Fe3O4 thin film grown on Mg2TiO4 (001)
Authors: Liu X. H. , Liu W. , Zhang Z. D. , Komarek A. C. , Chang C. F.
Published: January 2018

Correction for ‘Extremely low coercivity in Fe3O4 thin film grown on Mg2TiO4 (001)’ by X. H. Liu et al., RSC Adv., 2017, 7, 43648–43654.
Titania supported on silica as an efficient catalyst for deep oxidative desulfurization of a model fuel with exceptionally diluted H2O2
Authors: Piscopo C. G. , Tochtermann J. , Schwarzer M. , Boskovic D. , Maggi R. , Maestri G. , Loebbecke S.
Published: January 2018

The continuous ODS of a model fuel, catalyzed by titanium nanocrystals dispersed onto silica, was performed with <1% aqueous H2O2.
A DNA-conjugated small molecule catalyst enzyme mimic for site-selective ester hydrolysis
Authors: Flanagan Moira L. , Arguello A. Emilia , Colman Drew E. , Kim Jiyeon , Krejci Jesse N. , Liu Shimu , Yao Yueyu , Zhang Yu , Gorin David J.
Published: January 2018

A DNA-imidazole conjugate, designed to mimic enzyme function, site-selectively hydrolyzes a target ester, but not other esters, with >100-fold rate enhancement compared to free imidazole.
Multilayer thin films for the construction of active repulsive hydrogen barriers
Authors: Park Minwook , Kim Dae-Yoon , Kang Dong-Gue , Yoon Won-Jin , Choi Yu-Jin , Lee Joong Hee , Jeong Kwang-Un
Published: January 2018

Electrochemically activated hydrogen barrier thin films greatly improve the hydrogen gas barrier properties.
Accommodating volume change and imparting thermal conductivity by encapsulation of phase change materials in carbon nanoparticles
Authors: Advincula P. A. , de Leon A. C. , Rodier B. J. , Kwon J. , Advincula R. C. , Pentzer E. B.
Published: January 2018

A Pickering-type emulsion is used as a template to encapsulate the phase change material stearic acid (SA) using graphene oxide nanosheets stitched together.
Influence of metal substitution on hybrid halide perovskites: towards lead-free perovskite solar cells
Authors: Chatterjee Soumyo , Pal Amlan J.
Published: January 2018

Approaches to tune the properties of hybrid halide perovskites and their performance in solar cells through metal substitution have been summarized in this review.
Optimizing the conjugated side chains of quinoxaline based polymers for nonfullerene solar cells with 10.5% efficiency
Authors: Xu Shutao , Wang Xiaojing , Feng Liuliu , He Zhicai , Peng Hongjian , Cimrová Věra , Yuan Jun , Zhang Zhi-Guo , Li Yongfang , Zou Yingping
Published: January 2018

Quinoxaline (Qx) has an easily modifiable structure, which allows for fine-tuning its properties through optimizing the length of side chains and the kinds of aromatic rings in conjugated side chains.
Carbon nanotube-assisted synthesis of ferromagnetic Heusler nanoparticles of Fe3Ga (Nano-Galfenol)
Authors: Ghunaim Rasha , Eckert Victoria , Scholz Maik , Gellesch Markus , Wurmehl Sabine , Damm Christine , Büchner Bernd , Mertig Michael , Hampel Silke
Published: January 2018

Nano-Galfenol, or Heusler nanoparticles of the formula Fe3Ga, has been prepared by a novel method with the assistance of carbon nanotubes as a nano-carrier.
Thermally sensitive, adhesive, injectable, multiwalled carbon nanotube covalently reinforced polymer conductors with self-healing capabilities
Authors: Zhang Qiang , Liu Libin , Pan Chenguang , Li Dong , Gai Guangjie
Published: January 2018

The modified MWCNT covalently bound with polymers avoids aggregation and reinforces the mechanical performance of the composite.
Correction: Synthesis, spectroscopy, structures and antimicrobial activity of mixed-ligand zinc(ii) complexes of 5-nitro-salicylaldehyde thiosemicarbazones
Authors: Indoria Shikha , Lobana Tarlok S. , Sood Henna , Arora Daljit S. , Hundal Geeta , Jasinski Jerry P.
Published: January 2018

Correction for ‘Synthesis, spectroscopy, structures and antimicrobial activity of mixed-ligand zinc(ii) complexes of 5-nitro-salicylaldehyde thiosemicarbazones’ by Shikha Indoria et al., New J. Chem., 2016, 40, 3642–3653.
Engineering sub-100 nm Mo(1−x)WxSe2 crystals for efficient hydrogen evolution catalysis
Authors: Zhuang Minghao , Gan Li-Yong , Zou Mingchu , Dou Yubing , Ou Xuewu , Liu Zhenjing , Ding Yao , Abidi Irfan Haider , Tyagi Abhishek , Jalali Mahsa , You Jiawen , Cao Anyuan , Luo Zhengtang
Published: January 2018

Engineering sub-100 nm Mo(1-x)WxSe2 crystals for abundant edge exposure and optimal W doping for efficient hydrogen evolution catalysis.
5–20 Gbit/s adaptive CTLE with spectrum balancing method
Authors: Cai Chen , Zhou Yumei , Zhao Jianzhong
Published: January 2018

An adaptive continuous‐time linear equaliser using the optimised spectrum balancing (SB) method is proposed. The SB method is extended with a frequency detector to promote compensation ability of an equaliser and completes the optimal equalisation decision for multi‐data rates. The active inductor peaking technology is adopted to increase the bandwidth of an equaliser, save chip area and power consumption. Based on Huaili Microelectronics Corporation (HLMC) 40 nm CMOS process to achieve the overall design, the power consumption and chip area are 32.11 mW at 20 Gbit/s and 0.14 mm2, respectively. And it can offer a compensation range from 6 to 18 dB for 5–20 Gbit/s of receiving data.
Optimal integration of DERs in coordination with existing VRs in distribution networks
Authors: Meena Nand Kishor , Swarnkar Anil , Gupta Nikhil , Niazi Khaleequr Rehman
Published: January 2018

Voltage regulation (VR) and energy loss minimisation have always been major concerns for distribution network (DN) operators, thereby many conventional VR schemes are dedicatedly employed in existing DNs. In this study, optimal integration of different distributed energy resources (DERs) is investigated in coordination with existing VR scheme, i.e. on‐load tap‐changer. To show the superiority of the proposed DER integration model, optimal allocations of different DERs are determined with and without considering the coordinated effect of existing VR schemes for annual energy loss minimisation under different scenarios. To solve this complex optimisation problem, the improved genetic algorithm (GA) is adopted. A dynamic node priority list (DNPL) is suggested to further improve the performance of GA. To validate the proposed strategy and DNPL, the DER integration problem is solved for benchmark 33‐bus and real‐life 108‐bus Indian radial distribution systems. The simulation results are found to be inspiring when compared with the existing optimisation techniques and DER integration models without considering VR schemes.
Constrained integrated inventory model for multi-item under mixture of distributions
Authors: Uthayakumar R. , Ganesh Kumar M.
Published: January 2018

When the demand of different customers are not identical during the lead time, then one cannot use only a single distribution to describe the demand during that lead time. Hence, in this paper we have studied a mixture of normal distributions and a mixture of distribution free for several products under vendor-buyer integrated approach (coordination between both parties). Many integrated inventory models have proved that the integrated total cost is minimum when compared to sum of the total cost of the individuals. The inventory is continuously reviewed by the buyer and next order is placed when the inventory reaches some level called reorder level. The buyer has limited warehouse space capacity and also limited budget to purchase all products. The lead time of receiving all products from the vendor is a variable which is controlled by adding crashing cost. Shortages are allowed for all products and a fraction of shortages will be backordered and the remaining are lost. A mathematical model is developed and a solution procedure is employed in this study to obtain optimum order quantities, lead time and number of shipments in which the integrated total cost function attains its minimum subject to the floor space constraint and budget constraint. The expected integrated cost function is non-linear mixed integer with inequality constraints. Therefore, the proposed model have been solved by using Lagrangian multiplier technique. Finally numerical examples and sensitivity analysis were performed to illustrate the effectiveness of the proposed model.
Lipase-Induced Oxidative Furan Rearrangements
Authors: Deska Jan , Blume Fabian , Sprengart Petra
Published: January 2018

Lipase B from Candida antarctica catalyzes the oxidative ring expansion of furfuryl alcohols using aqueous hydrogen peroxide to yield functionalized pyranones under mild conditions. The method further allows for the preparation of corresponding piperidinone derivatives by enzymatic rearrangement of N-protected furfurylamines.
Enantioselective Synthesis of F-Ring Fragments of Kibdelone C via Desymmetrizing Bromolactonization of 1,4-Dihydrobenzoic Acid
Authors: Martin Stephen , Klosowski Daniel
Published: January 2018

We previously reported a bifunctional organic catalyst that promotes highly efficient enantioselective halolactonizations of a broad array of olefinic acids. As part of that work, we demonstrated the desymmetrization of a prochiral substrate through a catalytic enantioselective halolactonization, and we report herein the application of one such desymmetrization process to the syntheses of F-ring subunit synthons of (+)-kibdelone C.
Synthesis of Optically Pure (S,E)-2-Amino-5-arylpent-4-enoic Acids by Heck Reactions of Nickel Complexes
Authors: Langer Peter , Parpart Silvio , Mardiyan Zorayr , Ehlers Peter , Petrosyan Andranik , Mkrtchyan Anna , Saghyan Ashot
Published: January 2018

Starting from commercially available building blocks a variety of enantiomerically pure (S)-2-amino-4-enoic acids has been synthesized by the Heck reaction using Ni-(S)-BPB {Nickel-N-[(S)-benzylprolyl]aminobenzophenone} as a chiral auxiliary. The reactions proceeded in very good yields and with high E-selectivity.
Tuberculum Sellae Meningioma Resection: Technical Nuances on the Frontopterional Approach
Authors: Rustemi Oriela , Scienza Renato , Della Puppa Alessandro
Published: January 2018

Tuberculum sellae meningioma remains a surgical challenge. Deep location of tumor, vascular and nerve encasement, and pituitary stalk involvement are the main technical issues. The frontopterional approach represents a natural, simple, and elegant approach to this area enabling surgeon to have a direct control on all anatomical structures. A 42-year-old woman was referred with a delayed diagnosis of tuberculum sellae meningioma due to the presence of HLA-B27-associated uveitis. She presented with 1/10 visual acuity in the left eye and no right visual function. A left frontopterional craniotomy was performed. Visual function improved postoperatively. The video illustrates the cisternal anatomy via pterional approach.

The link to the video can be found at: https://youtu.be/Hmbf5bt7A64.
Implantação do Sistema de Procedimentos de Alta Complexidade em Neurocirurgia. Resultados
Authors: Sfreddo Ericson
Published: January 2018

Objetivo: Demonstrar a maneira como foi implementado o Serviço de Alta Complexidade em Neurocirurgia num município da região metropolitana de Porto Alegre e seus resultados benéficos à população, aos neurocirurgiões e à Instituição Hospitalar. Material e método: São demonstrados os argumentos que o grupo de neurocirurgiões adotou para convencer a direção do Hospital Municipal de Novo Hamburgo (HMNH) a investir na especialidade antes mesmo de ter noção real das vantagens e dos lucros que adviriam. Resultados: Foi constatado que havia uma evasão mensal de aproximadamente 30 pacientes dos municípios que compunham a região para outro centro de referência (“Hospital Referência”). Essa evasão propiciaria um rendimento em torno de R$ 57 mil. Foi demonstrado que o “Hospital Referência” havia saltado de um faturamento de pouco mais de R$ 100 mil para aproximadamente R$ 500 mil após a implantação do Sipac-Neuro, e que a média de valores das autorizações de internações hospitalares (AIH) desse hospital era de R$ 1.056,12 contra R$ 382,84 do HMNH. A seguir, descrevem-se os passos que foram necessários para o credenciamento junto ao Ministério da Saúde, a implantação do serviço e os futuros investimentos que se pretende realizar em função dos novos aportes financeiros proporcionados pela Alta Complexidade. Os resultados financeiros iniciais após o credenciamento foram significativos. Conclusão: A organização e demonstração real, com exemplos de outras instituições, são instrumentos úteis e facilitadores para o convencimento das direções de hospitais que ainda são céticos quanto às vantagens proporcionadas pelo Sipac-Neuro.
Sind G-BA Beschlüsse für die Versorgungssteuerung geeignet?
Authors: Holzerny Pascale , Werner Sebastian , Ruof Jörg
Published: January 2018

Zielsetzung Ziel dieser Übersichtsarbeit ist die Analyse der Übereinstimmung zwischen Leitlinien und G-BA Beschlüssen hinsichtlich i)
Patientengruppenbildung und ii) Leitlinienempfehlung versus Zusatznutzen.

Methoden Alle onkologischen AMNOG Beschlüsse von 1/2011 bis 5/2017 wurden einbezogen. Bei befristeten Verfahren wurden jeweils nur die
aktuellsten Beschlüsse berücksichtigt. Onkopedia wurde als die primäre Quelle für die klinisch-onkologischen Leitlinien berücksichtigt. Die
Konkordanz der Patientengruppenbildung wurde angenommen, wenn Leitlinien und G-BA Beschlüsse identische Patientengruppen beinhalteten.
Differierende Patientengruppen wurden als Diskordanz beschrieben. Die Konkordanz des G-BA Zusatznutzenbeschlusses zur entsprechenden
Leitlinienempfehlung wurdeangenommen, wenn vorhandener bzw. nicht belegter Zusatznutzen mit einer vorhandenen bzw. fehlenden Empfehlung in
den Leitlinien zusammenfiel. Diskordant waren Beschlüsse, die von der Leitlinienempfehlung divergierten.

Ergebnisse In die Analyse gingen 37 onkologische Medikamente mit 56 Verfahren und insgesamt 102 Patientengruppen ein. Hinsichtlich der
Patientengruppenbildung weicht der G-BA in 38 % (n = 39 von 102) partiell oder komplett von den in den Leitlinien dargestellten
Patientengruppen ab. Bezüglich der Übereinstimmung von Zusatznutzenbeschluss und Leitlinienempfehlung zeigt sich eine partielle oder
komplette Diskordanz bei 60 % der Patientengruppen (n = 61 von 102).

Schlussfolgerung G-BA Beschlüsse und Leitlinien in der Onkologie weisen sowohl hinsichtlich Patientengruppenbildung als auch bezüglich
Zusatznutzenbeschluss erhebliche Diskordanzen auf. Eine, am Patientenwohl orientierte, evidenzbasierte Steuerung der Versorgung sollte sich
primär an den von den klinischen Fachgesellschaften konzipierten Leitlinien orientieren.
Cognitive Deficits in Methamphetamine Users: How Strong is The Evidence?
Authors: Proebstl Lisa , Kamp Felicia , Koller Gabi , Soyka Michael
Published: January 2018

Methamphetamine use has spread in many European countries and the United States. The current review provides a summary and critical analysis of research on cognitive deficits associated with methamphetamine, also known as “crystal meth.” The literature search performed for this review led us to the hypothesis that methamphetamine use is associated with persistent changes in brain metabolism that result in various impairments, such as deficits in memory, attention, and concentration. The dopaminergic system in particular seems to be affected. Some studies indicate that cognitive impairments may improve when users become abstinent, but results of other studies are conflicting. This review discusses these findings and the consequences for the development of a specific addiction treatment for methamphetamine.
In vivo and in vitro strategies to support caprine preantral follicle development after ovarian tissue vitrification
Authors: Donfack N. J. , Alves K. A. , Alves B. G. , Rocha R. M. P. , Bruno J. B. , Lima L. F. , Lobo C. H. , Santos R. R. , Domingues S. F. S. , Bertolini M. , Smitz J. , Rodrigues A. P. R.
Published: January 2018

The aim of the present study was to compare fresh and vitrified goat ovarian tissue after autotransplantation and in vitro culture. Adult goats were completely ovariectomised and each ovarian pair was sliced and distributed among six different treatment groups: fresh control, fresh transplant, fresh culture, vitrified control, vitrified transplant and vitrified culture. Follicular morphology, development, growth, density, revascularisation and hormone production were evaluated in all groups. Three antral follicles (two in the fresh transplant and one in the vitrified transplant groups) were observed on the surface of the graft 90 days after transplantation. The percentage of morphologically normal follicles was similar in the fresh control, fresh transplant and vitrified transplant groups. The percentage of developing (transition, primary and secondary) follicles was higher after in vitro culture of fresh or vitrified tissue. Transplantation resulted in a lower follicle density. Serum oestradiol concentrations remained constant during the entire transplantation period. In contrast, progesterone production decreased significantly. Expression of CD31 mRNA was lower in fresh culture. In conclusion, restoration of goat ovarian function can be successfully achieved following transplantation of both fresh and vitrified goat ovarian tissue. However, transplantation induced higher follicle loss than in vitro culture.
Demonized, domesticated, virtualized: fortification buildings as a case of Prussian heritage in present-day Kaliningrad
Authors: Narvselius Eleonora
Published: January 2018

The article explores ways in which the nineteenth-century Prussian military architecture has been used and promoted as a part of the local heritage in the Russian exclave of Kaliningrad. Accommodation of the old fortification buildings to tourism and museum work has been publicly discussed since the beginning of the 2000s, but neither local nor federal authorities have proposed a plan to adapt them to non-military purposes. As a result, these structures, which are protected by federal heritage laws and uniformly built of characteristic red bricks, have become an arena for various initiatives, experiments, and games with the past. Strategies of virtualization discussed in the paper reveal a lack of open public discussion about dark episodes of Russian and Soviet history. Consequently, it is important to learn more about how and why contemporary Kaliningraders appropriate the local German legacies, use globally accepted strategies of heritage construction, and develop cooperation with the EU countries, while remaining receptive to official historical narratives promulgated by the national center.
Development of functional agricultural products utilizing the new health claim labeling system in Japan
Authors: Maeda-Yamamoto Mari , Ohtani Toshio
Published: January 2018

In April 2015, Consumer Affairs Agency of Japan launched a new food labeling system known as “Foods with Function Claims (FFC).” Under this system, the food industry independently evaluates scientific evidence on foods and describes their functional properties. As of May 23, 2017, 1023 FFC containing 8 fresh foods have been launched. Meanwhile, to clarify the health-promoting effects of agricultural products, National Agriculture and Food Research Organization (NARO) implemented the “Research Project on Development of Agricultural Products” and demonstrated the risk reduction of osteoporosis of β-cryptoxanthin rich Satsuma mandarins and the anti-allergic effect of the O-methylated catechin rich tea cultivar Benifuuki. These foods were subsequently released as FFC. Moreover, NARO elucidated the health-promoting effects of various functional agricultural products (β-glucan rich barley, β-conglycinin rich soybean, quercetin rich onion, etc.) and a healthy boxed lunch. This review focuses on new food labeling system or research examining functional aspects of agricultural products.
Biosynthesis of galactomannans found in filamentous fungi belonging to Pezizomycotina
Authors: Oka Takuji
Published: January 2018

The galactomannans (GMs) that are produced by filamentous fungi belonging to Pezizomycotina, many of which are pathogenic for animals and plants, are polysaccharides consisting of α-(1→2)-/α-(1→6)-mannosyl and β-(1→5)-/β-(1→6)-galactofuranosyl residues. GMs are located at the outermost layer of the cell wall. When a pathogenic fungus infects a host, its cell surface must be in contact with the host. The GMs on the cell surface may be involved in the infection mechanism of a pathogenic fungus or the defense mechanism of a host. There are two types of GMs in filamentous fungi, fungal-type galactomannans and O-mannose type galactomannans. Recent biochemical and genetic advances have facilitated a better understanding of the biosynthesis of both types. This review summarizes our current information on their biosynthesis.
The presence of free d-aspartate in marine macroalgae is restricted to the Sargassaceae family
Authors: Yokoyama Takehiko , Tokuda Masaharu , Amano Masafumi , Mikami Koji
Published: January 2018

The presence of d-aspartate (d-Asp), a biologically rare amino acid, was evaluated in 38 species of marine macroalgae (seaweeds). Despite the ubiquitous presence of free l-Asp, free d-Asp was detected in only 5 species belonging to the Sargassaceae family of class Phaeophyceae (brown algae) but not in any species of the phyla Chlorophyta (green algae) and Rhodophyta (red algae). All other members of Phaeophyceae, including 3 species classified into the section Teretia of Sargassaceae did not contain d-Asp. These results indicate that the presence of free d-Asp in marine macroalgae is restricted only to the Sargassaceae family, excluding the species in the section Teretia.
Fluctuation – a common but neglected pattern of physical activity behaviour: An exploratory review of studies in recent 20 years
Authors: Shang Borui , Duan Yanping , Huang Wendy Yajun , Brehm Walter
Published: January 2018

Background: Regular physical activity (PA) is beneficial for physical and psychological well‐being, yet many people do not achieve these health benefits due to irregular PA participation which is also known as fluctuation. Limited attention has been given to the phenomenon of fluctuation in the PA behaviour literature. Objective: The aim of this review was to explore and to map definitions, measurements, behavioural evidence, and factors related to PA fluctuation. Methods: Eligible studies were initially identified by a systematic search of articles conducted in four databases: Scopus, PubMed, PsycINFO, and SPORTDiscus between January 1996 and March 2016. Inclusion and exclusion criteria were set to check the eligibility of all articles. Additional articles were included by manual searching and expert recommendation. Results: Fifteen articles were finally included. Definitions of fluctuation are understood from two perspectives, either as a stage in the process of behaviour change, or as a particular PA phenomenon consisting of lapse and readoption. Common features were extracted: behavioural irregularity, high risk of drop‐out, intention and readiness for PA, low automaticity, and limited self‐regulation. Furthermore, fluctuation identification was summarised in three approaches such as stage algorithm, self‐identified PA lapse and readoption, and prospective within‐person variation in meeting the PA guidelines. Regarding the empirical evidence, this review found that people in PA fluctuation were significantly distinct from those in preparation and maintenance of PA behavioural performance, as well as distinct in psychosocial features. Conclusions: Notwithstanding the limitations, this review has provided valuable insight into the phenomenon of PA fluctuation.
Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen
Authors: Ueta Hisashi , Kitazawa Yusuke , Sawanobori Yasushi , Ueno Takamasa , Ueha Satoshi , Matsushima Kouji , Matsuno Kenjiro
Published: January 2018

Donor-specific blood transfusion is known to induce alloresponses and lead to immunosuppression. We examined their underlying mechanisms by employing fully allogeneic rat combinations. Transfused recipients efficiently produced alloantibodies of the IgM and IgG subclasses directed against donor class I MHC. The recipients exhibited active expansion of CD4+ T cells and CD4+FOXP3+ regulatory T cells (Treg cells), followed by CD45R+ B cells and IgM+ or IgG subclass+ antibody-forming cells mainly in the spleen. From 1.5 days, the resident MHCII+CD103+ dendritic cells (DCs) in the splenic T-cell area, periarterial lymphocyte sheath, formed clusters with recipient BrdU+ or 5-ethynyl-2′-deoxyuridine+ cells, from which the proliferative response of CD4+ T cells originated peaking at 3–4 days. Transfusion-induced antibodies had donor passenger cell-depleting activity in vitro and in vivo and could suppress acute GvH disease caused by donor T cells. Furthermore, Treg cells significantly suppressed mixed leukocyte reactions in a donor-specific manner. In conclusion, single blood transfusion efficiently induced a helper T-cell-dependent anti-donor class I MHC antibody-forming cell response with immunoglobulin class switching, and a donor-specific Treg cell response mainly in the spleen, probably by way of the indirect allorecognition via resident DCs. These antibodies and Treg cells may be involved, at least partly, in the donor-specific transfusion-induced suppression of allograft rejection.
Source selection for cluster weak lensing measurements in the Hyper Suprime-Cam survey
Authors: Medezinski Elinor , Oguri Masamune , Nishizawa Atsushi J , Speagle Joshua S , Miyatake Hironao , Umetsu Keiichi , Leauthaud Alexie , Murata Ryoma , Mandelbaum Rachel , Sifón Cristóbal , Strauss Michael A , Huang Song , Simet Melanie , Okabe Nobuhiro , Tanaka Masayuki , Komiyama Yutaka
Published: January 2018

We present optimized source galaxy selection schemes for measuring cluster weak lensing (WL) mass profiles unaffected by cluster member dilution from the Subaru Hyper Suprime-Cam Strategic Survey Program (HSC-SSP). The ongoing HSC-SSP survey will uncover thousands of galaxy clusters to z ≲ 1.5. In deriving cluster masses via WL, a critical source of systematics is contamination and dilution of the lensing signal by cluster members, and by foreground galaxies whose photometric redshifts are biased. Using the first-year CAMIRA catalog of ∼900 clusters with richness larger than 20 found in ∼140 deg2 of HSC-SSP data, we devise and compare several source selection methods, including selection in color–color space (CC-cut), and selection of robust photometric redshifts by applying constraints on their cumulative probability distribution function (P-cut). We examine the dependence of the contamination on the chosen limits adopted for each method. Using the proper limits, these methods give mass profiles with minimal dilution in agreement with one another. We find that not adopting either the CC-cut or P-cut methods results in an underestimation of the total cluster mass (13% ± 4%) and the concentration of the profile (24% ± 11%). The level of cluster contamination can reach as high as ∼10% at R ≈ 0.24 Mpc/h for low-z clusters without cuts, while employing either the P-cut or CC-cut results in cluster contamination consistent with zero to within the 0.5% uncertainties. Our robust methods yield a ∼60 σ detection of the stacked CAMIRA surface mass density profile, with a mean mass of M200c = [1.67 ± 0.05(stat)] × 1014 M⊙/h.
Non-ontological Structuralism†
Authors: Resnik Michael
Published: January 2018

Historical structuralist views have been ontological. They either deny that there are any mathematical objects (eliminative structuralism) or they maintain that mathematical objects are structures or positions in them (sui generis structuralism). Non-ontological structuralism offers no account of the nature of mathematical objects. My own structuralism has evolved from an early sui generis version to a non-ontological version that embraces Quine’s doctrine of ontological relativity. In this paper I further develop and explain this view.
Heterologous Expression of Rhizobial CelC2 Cellulase Impairs Symbiotic Signaling and Nodulation in Medicago truncatula
Authors: Robledo Marta , Menéndez Esther , Jiménez-Zurdo Jose Ignacio , Rivas Raúl , Velázquez Encarna , Martínez-Molina Eustoquio , Oldroyd Giles , Mateos Pedro F.
Published: January 2018

The infection of legume plants by rhizobia is tightly regulated to ensure accurate bacterial penetration, infection, and development of functionally efficient nitrogen-fixing root nodules. Rhizobial Nod factors (NF) have key roles in the elicitation of nodulation signaling. Infection of white clover roots also involves the tightly regulated specific breakdown of the noncrystalline apex of cell walls in growing root hairs, which is mediated by Rhizobium leguminosarum bv. trifolii cellulase CelC2. Here, we have analyzed the impact of this endoglucanase on symbiotic signaling in the model legume Medicago truncatula. Ensifer meliloti constitutively expressing celC gene exhibited delayed nodulation and elicited aberrant ineffective nodules, hampering plant growth in the absence of nitrogen. Cotreatment of roots with NF and CelC2 altered Ca2+ spiking in root hairs and induction of the early nodulin gene ENOD11. Our data suggest that CelC2 alters early signaling between partners in the rhizobia-legume interaction.
Biological Control of Botrytis cinerea: Interactions with Native Vineyard Yeasts from Washington State
Authors: Wang Xuefei , Glawe Dean A. , Kramer Elizabeth , Weller David , Okubara Patricia A.
Published: January 2018

Native yeasts are of increasing interest to researchers, grape growers, and vintners because of their potential for biocontrol activity and their contributions to the aroma, flavor, and mouthfeel qualities of wines. To assess biocontrol activity, we tested 11 yeasts from Washington vineyards, representing isolates of Candida saitoana, Curvibasidium pallidicorallinum, Metschnikowia chrysoperlae, M. pulcherrima, Meyerozyma guilliermondii, Saccharomyces cerevisiae, and Wickerhamomyces anomalus, for ability to colonize Thompson Seedless grape berries, inhibit the growth of Botrytis cinerea in vitro, and suppress disease symptoms on isolated berries. The yeast-like fungus Aureobasidium pullulans was also included based on its known biocontrol activity against B. cinerea in studies on apple and grape. All yeast strains multiplied rapidly in grape berries and reached densities of over log 6 cells per wound as early as 2 days after inoculation with 200 cells. One of the Botrytis isolates used in this study was much less virulent than the others and was provisionally identified as B. prunorum based on multilocus sequence analysis. Suppression of the growth of B. cinerea isolates 111bb, 207a, 207cb, and 407cb occurred on berries treated with A. pullulans P01A006, Metschnikowia chrysoperlae P34A004 and P40A002, M. pulcherrima P01A016 and P01C004, Meyerozyma guilliermondii P34D003, and S. cerevisiae HNN11516. Inhibition of Botrytis isolates by the yeast strains was more common on berries than in vitro, suggesting the possibility that niche competition was a more likely biocontrol mechanism than antibiosis in planta. Metabolic profiling of yeast strains and B. cinerea isolates using Biolog YT plates revealed seven distinct metabolic groups. Furthermore, the yeast strains showed partial to complete tolerance to the commonly used fungicides fluopyram, triflumizole, metrafenone, pyraclostrobin, and boscalid. Implications of these findings for field deployment of native Washington yeasts as biocontrol agents against B. cinerea are discussed.
CASQ1 Gene Is an Unlikely Candidate for Malignant Hyperthermia Susceptibility in the North American Population
Authors: Kraeva Natalia , Zvaritch Elena , Frodis Wanda , Sizova Olga , Kraev Alexander , MacLennan David H. , Riazi Sheila
Published: January 2018

Background

Malignant hyperthermia (MH, MIM# 145600) is a complex pharmacogenetic disorder that is manifested in predisposed individuals as a potentially lethal reaction to volatile anesthetics and depolarizing muscle relaxants. Studies of CASQ1-null mice have shown that CASQ1, encoding calsequestrin 1, the major Ca2+ binding protein in the lumen of the sarcoplasmic reticulum, is a candidate gene for MH in mice. The aim of this study was to establish whether the CASQ1 gene is associated with MH in the North American population.

Methods

The entire coding region of CASQ1 in 75 unrelated patients diagnosed by caffeine-halothane contracture test as MH susceptible (MHS) was analyzed by DNA sequencing. Subsequently, three groups of unrelated individuals (130 MHS, 100 MH negative, and 192 normal controls) were genotyped for a variant that was identified by sequencing. Levels of CASQ1 expression in the muscle from unrelated MHS and MH negative individuals were estimated by Western blotting.

Results

Screening of the entire coding sequence of the CASQ1 gene in 75 MHS patients revealed a single variant c.260T > C (p.Met87Thr) in exon 1. This variant is unlikely to be pathogenic, because its allele frequency in the MHS group was not significantly different from that of controls. There was also no difference in calsequestrin 1 protein levels between muscle samples from MHS and controls, including those carrying the p.Met87Thr variant.

Conclusions

This study revealed a low level of protein coding sequence variability within the human CASQ1 gene, indicating that CASQ1 is not a major MHS locus in the North American population.
Opioid Use Disorders Attributed to Tramadol Among Egyptian University Students
Authors: Bassiony Medhat M. , Abdelghani Mohamed , Salah El-Deen Ghada M. , Hassan Mervat S. , El-Gohari Hayam , Youssef Usama M.
Published: January 2018

Background:

Tramadol use is an overwhelming problem in Egypt with tremendous medical and social consequences especially among youth. Use liability among Egyptian university students is underevaluated. This study aimed to estimate the prevalence and associated correlates of tramadol use among students from Zagazig University, Egypt.

Methods:

A cross-sectional study included a total of 1135 undergraduate students, from 10 colleges in Zagazig University. Participants were randomly selected and assessed for tramadol use using The Drug Use Disorders Identification Test (DUDIT) and The Drug Use Disorders Identification Test—Extended (DUDIT-E).

Results:

The prevalence of tramadol use was 12.3% among university students, with higher prevalence in male (20.2%) than female students (2.4%). The average age at onset of tramadol use was 17.6 ± 2.1. Only 15% of the students with substance use were using tramadol alone whereas the rest (85%) were using at least 1 drug plus tramadol. One-fifth of these students started with tramadol as their first drug. Smoking, cannabis, and alcohol use predict tramadol use. About 60% of students who use tramadol had drug-related problems and 30% had dependence. Treatment readiness for tramadol use is negatively correlated with smoking and its duration.

Conclusions:

Tramadol use was common among university students, with higher prevalence among males. There is a considerable relationship between tramadol use, smoking, and use of other substances. Further population-based longitudinal studies need to investigate the causal relationship between tramadol use, smoking, and use of other substances.
Immediate Breast Reconstruction among Patients with Medicare and Private Insurance: A Matched Cohort Analysis
Authors: Kamali Parisa , Ricci Joseph A. , Curiel Daniel A. , Cohen Justin B. , Chattha Anmol , Rakhorst Hinne A. , Lee Bernard T , Lin Samuel J.
Published: January 2018

Background:

By eliminating economic hurdles, the Women’s Health and Cancer Rights Act of 1998 represented a paradigm shift in the availability of breast reconstruction. Yet, studies report disparities among Medicare-insured women. These studies do not account for the inherent differences in age and comorbidities between a younger privately insured and an older Medicare population. We examined immediate breast reconstruction (IBR) utilization between a matched pre- and post-Medicare population.

Methods:

Using the Nationwide Inpatient Sample database (1992–2013), breast cancer patients undergoing IBR were identified. To minimize confounding medical variables, 64-year-old privately insured women were compared with 66-year-old Medicare-insured women. Demographic data, IBR rates, and complication rates were compared. Trend over time was plotted for both cohorts.

Result:

A total of 21,402 64-year-old women and 25,568 66-year-old women were included. Both groups were well matched in terms of demographic type of reconstruction and complication rates. 72.3% of 64-year-old and 71.2 of % 66-year-old women opted for mastectomy. Of these, 25.5% (n = 3,941) of 64-year-old privately insured and 17.7% (n = 3,213) of 66-year-old Medicare-insured women underwent IBR (P < 0.01). During the study period, IBR rates increased significantly in both cohorts in a similar cohort.

Conclusion:

This study demonstrates significant increasing IBR rates in both cohorts. Moreover, after an initial slower upward trend, after a decade, IBR in 66-year-old Medicare-insured women approached similar rates of breast reconstruction among those with private insurance. Trends in unilateral versus bilateral mastectomy are also seen.