bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Unmanned Aerial Vehicles in Geodesy on the Example of Aerial Photogrammetric System SenseFly eBee
Authors: Žilić Amel
Published: February 2024

During the last few years a completely new method for land and object surveying was devloped. Using unmanned aerial vehicle, it is possible to survey a large areas in very short period of time with high accuraccy. Although there are still many uncertainties, it is inevitable that this method represents the future in geodesy and its areas. This paper defines a method for land surveying using SenseFly eBee drone and proccess of creating point cloud, digital model of relief and digital ortofoto map. Using NSSDA standard for spatial data accuraccy on drone products, it was concluded that accuraccy of given results depends on the ground resolution, terrain relief and weather conditions.
Experience With the Use of Real Estate Cadastre Database
Authors: Dinar Ilma
Published: February 2024

Federal Administration for Geodetic and Property Affairs has implemented the project of creating a real estate cadastre database for most of the municipalities of the Federation of Bosnia and Herzegovina (FBiH) during recent years. It has brought various changes in the work of cadastral offices. This article describes these changes, which were not occurred in the former practice of maintaining the cadastral records.
Rotation of Earth and Determination of Earth Orientation Parameters
Authors: Borisov Mirko , Govedarica Miro , Orihan Maja
Published: February 2024

Earth's rotation and elements of the Earth's orientation, with emphasis on the determination of the parameters of the Earth's orientation were described. The technique that was used for the determination of the parameters is called very long baseline interferometry, VLBI. After determining the parameters of the Earth's orientation, the obtained results were compared using different reference frames, and the factors that have influence on their changes were also analyzed. For comparison were used vievstTrf and vtrf2008 reference frames. Data processing is performed in software VieVS (Vienna VLBI Software). The data used belong to program different series that are continuously observed every three years.
Evaluating Training Data for Crop Type Classifıcation Using Support Vector Machine and Random Forests
Authors: Ustuner Mustafa , Balik Sanli Fusun
Published: February 2024

This study evaluated the effectiveness of three different training datasets for crop type classification using both support vector machines (SVMs) and random forests (RFs). In supervised classification, one of the main facing challanges is to define the training set for the full representation of land use/cover classes. The adaptation of traning data, with the implemented classifier and its characteristics (purity, size and distribution of sample pixels), are of key importance in this context. The experimental results were compared in terms of the classification accuracy with 10-fold cross validation. Results suggest that higher classification accuracies were obtained by less number of training samples. Furthermore, it is highlighted that both methods (SVMs and RFs) are proven to be the effective and powerful classifiers for crop type classification.
Changes in the Level of Magnetic Declination in the Adriatic from 1806 to 1995 – a Contribution to the History of Adriatic Seafaring
Authors: Kozličić Mithad , Uglešić Sanda
Published: February 2024

The paper analyzes changes in magnetic declination in the Adriatic Sea from the first measurements in 1806 to the latest isogonic charts from 1995. The basis of analysis are data provided by the Adriatic pilot books as literature that mariners used as an indispensable instrument in sailing that has not been properly evaluated in the scientific research so far. It is emphasized the the magnetic declination was relevant primarily to overseas ferries, and was less important in coastal navigation, usually along the archipelagos of the eastern Adriatic maritime zone as terrestrial navigation was used in sailing in this belt with over a thousand islands and islets.
Travel barriers affecting subjective wellbeing in Tampere, Finland
Authors: Sjögren Jussi , Tiikkaja Hanne , O'Hern Steve
Published: February 2024

Travel is an important activity enabling everyday life, as well as a recognised factor for the wellbeing of people. This study examined how experienced travel barriers and their effect on access to important destinations influenced subjective wellbeing (SWB). The study comprised a survey of 772 people living in two suburban areas of Tampere, Finland. The survey included questions about everyday travel, travel barriers, and their effect on access to destinations. SWB was measured using the Personal Wellbeing Index (PWI). Responses were analysed by comparing PWI scores with travel barriers and access to destinations using one way ANOVA. Results indicate a significant connection between several experienced barriers and SWB. Some travel barriers were associated with a worrying decline to critically low level of SWB, which raised questions about transport equity and connections between travel and wellbeing in the context of Finnish transport system.
Efficient bicycle networks and expansion strategies
Authors: Talvitie Joel , Kuivalainen Veeti
Published: February 2024

This article explains some of the key attributes and factors relating to efficient bicycle networks and their expansion strategies. Varying from a network scale to brief discussion about the streetscape design, many scientific publications are referenced to explain the crucial aspects which must be taken into consideration when planning an attractive cycling network. Modal switch from other transport modes, especially from cars is one of the goals of this cycling promotion. Various methods such as building new bicycle facilities, improving the quality of existing ones and increasing the comfort and safety of the connections were found to improve the attractiveness of cycling in urban context. Additionally, this article analyses the reasons behind cyclists’ route choice as well as the metrics such as connectedness, directedness and coverage which can be used to measure the level of network functionality. Lastly, network growth under limited resources is considered and an equitable distribution of cycleways across the city is found to be important in preventing neighbourhood segregation while not being too far from a utilitarian kind of distribution in terms of return to investment.
Characteristics of Tenders As A Pre-Contract Stage for the Procurement of Goods and Services
Authors: Hasran Hasran , Indrasakti Addy , Wicaksono Agung Salim
Published: February 2024

Tendering in procuring goods and services is a crucial early stage in forming a fair procurement contract. This study aims to analyse the characteristics of tenders as a pre-contract stage of public procurement of goods and services. This research uses a qualitative research method with a descriptive approach. A literature study carried out the data collection technique in this research. The data that has been collected is then analysed in three stages, namely data reduction, data presentation, and conclusion drawing. The results showed that the characteristics of tenders as a pre-contract stage of government procurement of goods and services include competitive, fair, transparent, efficient, and effective. These tender characteristics are essential to consider in procuring government goods and services to produce quality goods and services providers who can carry out work correctly and on time
The Role of Restitution in Trafficking
Authors: Respati Paramudhita H Radea
Published: February 2024

Trafficking in Persons (TPPO) is a grave human rights violation because it causes various negative impacts on victims physically, psychologically, or socio-economically; one of the efforts to restore victims of TPPO is through restitution. This research explores the role of restitution in the context of TPPO. This research adopts a qualitative approach by collecting data through a literature study. Furthermore, the data is analysed through three stages: data reduction, data presentation, and conclusion drawing. The findings of the research indicate that restitution plays a vital role as a remedy and legal protection for victims of human trafficking. In its application, the punishment for the obligation to pay restitution can be replaced with imprisonment. Criminal punishment is not merely a deterrent effect on the convicted person, but recovery for the victim of the crime itself through restitution must be considered.
Streetscape Characteristic of The Coastal Area
Authors: P. Egam Pingkan , M. Rengkung Michael , M. Rompas Leidy , H. Thambas Arthur
Published: February 2024

The city corridor is a strategic area with its own aesthetic and functional value. In connection with the city's beauty, streetscape is one of the determining aspects in terms of architecture and spatial planning. The existence of streetscape tends to be overlooked, resulting in the area lacking identity. The presence of streetscape with character can provide a strong identity for the area, especially when the corridor in question has strategic value in terms of function and location. Proximity to the coastal area is indeed one of the advantages, although currently, it is still hidden, especially architecturally. This research aims to analyze streetscape elements with a coastal area approach. The research location is in the corridor of Piere Tendean Street, Manado, divided into 3 segments. The observed units include pedestrians, street furniture, activities, and buildings on the roadside. The conclusion is obtained that there are soft elements, hard elements, mobile elements, and natural elements. Elements closely related to the coastal area are mobile elements, such as activities enjoying the beauty of the beach equipped with breakwaters, activities in pedestrian and park locations, as well as fishing activities conducted in the empty space where the river meets the beach.
The Effect Of Crop Spacing And Dossage Of Potassium Fertilizer On Growth And Yield Of Sweet Corn (Zea mays Var. saccharata Sturt) Bonanza Cultivar
Authors: Nurliawati Gita , Faqih Achmad
Published: February 2024

The development of sweet corn in Indonesia using cultivation techniques in the form of crop spacing is expected to affect the plant population and affect the competition between plants in using water and nutrients, and the application of potassium fertilizer functions in the formation of sugar and starch, sugar translocation, enzyme activity and stomatal movement. The research was conducted in Gombang Village, Plered District, Cirebon Regency from March to June 2023. The treatment used a Randomized Group Design (RAK) factorial pattern consisting of two factors, namely crop spacing and potassium fertilizer dose, obtained 9 treatment combinations and repeated 3 times, so that in total there were 27 experimental plots. The results showed that the spacing of 50 cm x 40 cm (J2) and potassium fertilizer dossage of 100 kg K2O/ha (K2) showed the best effect on the weight of the corn cob with husks per plot which produced 31.85 kg/plot or equivalent to 21.23 tons/ha. There was a significant correlation between the growth components of plant height at 5 weeks and 6 weeks and the number of leaves at 4 weeks and 5 weeks with the weight of the corn cob with husks per plot.
Evaluating Measurements: A Comparative Study of Digital and Plaster Models for Orthodontic Applications in Mixed Dentition
Authors: Shin Seo Young , Chae Yong Kwon , Lee Ko Eun , Kim Mi Sun , Nam Ok Hyung , Lee Hyo-seol , Choi Sung Chul
Published: February 2024

This study aimed to assess the accuracy of tooth widths, intermolar widths, and arch lengths acquired through two intraoral scanners, including iTero Element Plus Series (Align Technology, Santa Clara, CA, USA) and Trios 4 (3Shape, Copenhagen, Denmark), specifically on mixed dentition. A total of 30 subjects were divided into 2 groups, each undergoing both alginate impressions and intraoral scanning using either the iTero or Trios scanner. The plaster models were measured with a caliper, while the digital models were measured virtually. In the iTero group, all tooth width measurements exhibited differences compared to the plaster values, except for maxillary left lateral incisors (p = 0.179), mandibular right (p = 0.285), and left (p = 0.073) central incisors. The Trios group did not display significant differences in any of the tooth width measurements. Intermolar width comparisons for both groups indicated differences, except for mandibular primary canine to primary canine values (p = 0.426) in the iTero group. Regarding arch length, the mandibular anterior, maxillary right, and left arch lengths in the iTero group demonstrated larger caliper values than those of iTero. Conversely, in the Trios group, all parameters showed smaller caliper values, especially in upper anterior, maxillary right, mandibular right, and mandibular left arch lengths with significance (p = 0.027, 0.007, 0.003, and 0.047, respectively). Despite the differences between the two groups, digital models might be clinically suitable alternatives for plaster models. Pediatric dentists should carefully assess these differences, as a comprehensive evaluation would result in precise orthodontic treatment planning and favorable outcomes for young patients with mixed dentition.
Evaluation of the Remineralization Capacity of Water-based Silver Fluoride
Authors: Kim Gwangsuk , Lee Juhyun , Kim Haeni
Published: February 2024

Silver diamine fluoride, which can arrest dental caries, is alkaline and may cause mild soft tissue irritation. Water-based silver fluoride has a neutral pH, which is closer to the physiological range, and is biocompatible for use in the oral environment. This study aimed to evaluate the effect of water-based silver fluoride on remineralizing early enamel lesions by comparing it with other fluoride agents through microhardness and quantitative light-induced fluorescence measurements. An in vitro study with intact bovine incisors was performed. Artificial enamel lesions were induced and subjected to microhardness and quantitative light-induced fluorescence testing. Specimens were randomly divided into 4 groups for treatment. The specimens in group I were treated with water-based silver fluoride and potassium iodide, group II with silver diamine fluoride and potassium iodide, group III with sodium fluoride varnish, and group IV with distilled water. After 8 days of pH cycling, the specimens were subjected to microhardness and quantitative light-induced fluorescence testing. Water-based silver fluoride and silver diamine fluoride showed the greatest increases in microhardness and quantitative light-induced fluorescence, with no significant differences between the two. Sodium fluoride varnish also exhibited a significant increase in microhardness and quantitative light-induced fluorescence, but the differences were smaller than those for water-based silver fluoride and silver diamine fluoride. Water-based silver fluoride is considered useful in a clinical setting for remineralizing enamel lesions, with the advantages of no risk of tissue burn and improved taste and smell.
Clinical Usefulness of the Jones Jig Appliance for Alignment of Premolars and Molars: Case Reports
Authors: Shin Wonkyu , Kim Hyuntae , Song Ji-Soo , Shin Teo Jeon , Kim Young-Jae , Kim Jung-Wook , Jang Ki-Taeg , Hyun Hong-Keun
Published: February 2024

Early loss of the primary maxillary second molar can lead to complications in which mesial drift of the adjacent first molar (M1) can disturb eruption of the succedaneous second premolar (P2). This study reports two cases of space loss for P2 caused by early exfoliation of its predecessor. After the eruption of the first premolar, the Jones jig appliance was used to distalize M1 and regain space for the eruption of P2. The appliance was further utilized to align the palatally erupted P2 into the dental arch. In both cases, the space and corrected position of P2 were well maintained. Early exfoliation of the primary second molar caused by mesial encroachment of M1 is a common phenomenon, and pediatric dentists should attend to this during routine examinations. An appropriate intervention should be initiated when the primary second molar is lost during the mixed dentition period. If used with careful anchorage control, the Jones jig appliance can effectively resolve this problem.
Moving to open source
Authors: Levchenko Maria
Published: February 2024

 Europe PMC POSI update – 2 years on  Two years have sailed by since Europe PMC adopted the Principles of Open Scholarly Infrastructure (POSI) in February 2021. POSI is a set of guidelines for open scholarly infrastructure providers and outlines how these organisations should be run and sustained. It offers a framework to uphold transparency and accountability.
How learning evidence synthesis (systematic reviews etc) changed the way I search and some thoughts about semantic search as a complement search technique
Authors: Tay Aaron
Published: February 2024

I've spent a large part of my career as an academic librarian studying the question of discovery from many angles.
In silico approach in the development of structural analogues of resveratrol with improved distribution in the central nervous system
Authors: Mitrović Darko , Pavlović Nebojša
Published: February 2024

Resveratrol exerts neuroprotective effects that are not only due to anti inflammatory and antioxidant activity but also by launched biogenesis via sirtuin-1 (SIRT1) protein that protects cells from oxidative stress. Resveratrol has low bioavailability due to low aqueous solubility and rapid metabolism. To improve the pharmacological profile, one of the strategies is the structural modification and selecting an analogue that would activate SIRT1 and improve pharmacokinetics. The aim was to examine the neuroprotective potential of resveratrol analogues through the analysis of the binding affinity to the sirtuin-1 receptor and with improved permeability through the blood-brain barrier. 15 of them have a higher affinity for the target. Four analogues are characterized by better properties including both higher permeability and higher binding affinity for SIRT1 compared to resveratrol. The selected compounds are assumed to have better bioavailability and CNS distribution, and further studies are proposed to confirm their effects and use as neuroprotective agents.
Assessing the Transfer Pricing Automation Potential: The Role of Human Capabilities
Authors: Plesner Rossing J.C. , Tigre J. Alves
Published: February 2024

Tax departments continue to explore ways to streamline operational transfer pricing processes. Automation is, in theory, a rational choice for handling the increased burden of tightened transfer pricing regulations and compliance requirements. However, many multinationals continue to use various manual applications for handling pricing and documentation obligations. In this article, the authors address this paradox and argue that in-house human capabilities play a significant role in the potential transition towards automation that needs to be addressed when assessing the degree of automation readiness. Essentially, multinationals need to go beyond an evaluation of technical and system conditions when determining if automation tools can realistically be deployed in operational transfer pricing processes.
PERAN PENDIDIKAN AGAMA KRISTEN DALAM PEMBENTUKAN NILAI MORAL REMAJA MASA KINI
Authors: Andrian Tonny
Published: February 2024

Pendidikan Agama Kristen memiliki peran sentral dalam membentuk nilai moral remaja masa kini yang dihadapkan pada berbagai tantangan dan perubahan zaman. Remaja masa kini mengalami krisis moral yang kompleks, dipengaruhi oleh dinamika globalisasi, perkembangan teknologi, dan perubahan budaya. Tujuan dari artikel ini adalah 1). Untuk mengetahui tantangan pendidikan agama kristen di era remaja masa kini; 2). Pendidikan agama kristen sebagai fondasi nilai moral remaja masa kini; 3). Kontribusi pendidikan agama kristen dalam membentuk nilai-nilai moral remaja masa kini. Metode yang digunakan yaitu kualitatif dengan pendekatan kepustakaan. Hasil yang ditemukan adalah 1). Untuk mengatasi tantangan ini, pendidikan Agama Kristen perlu mengembangkan strategi yang responsif, termasuk memberikan panduan moral Kristen yang sesuai, memfasilitasi pemahaman identitas Kristiani, dan menciptakan lingkungan pembelajaran menarik. Dukungan terhadap kesehatan mental dan emosional remaja serta penguatan keterlibatan gereja juga menjadi bagian penting dalam menanggapi krisis moral remaja; 2). Pendidikan agama Kristen merupakan suatu upaya yang memiliki tujuan utama untuk memuliakan Allah, dengan Alkitab sebagai dasar utamanya. Didukung oleh nilai-nilai pendidikan Kristen, proses ini mengajak individu untuk mengenal pribadi Kristus, dan menjadikan ajaran Alkitab sebagai panduan hidup; 3). Dengan memberikan fondasi nilai Kristen, mendorong penerapan nilai-nilai tersebut dalam kehidupan sehari-hari, dan beradaptasi dengan dinamika kontemporer.
Municipal Fiscal Stress, Bankruptcies, and Other Financial Emergencies
Authors: Justice Johnathan
Published: February 2024

Guzman, T., & Ermasova, N. (2023). Municipal fiscal stress, bankruptcies, and other financial emergencies. Routledge, 310 pp., $49.95 (paperback), ISBN: 978-1-032-34938-1.
Taxation Aspects of Corporate Taxpayers
Authors: Ambarita Dinar , Kusuma Eka , Kwartani Yunita
Published: February 2024

This research delves into the intricate taxation aspects surrounding corporate taxpayers. It examines the various dimensions of corporate taxation, including the principles governing corporate tax liabilities, tax planning strategies, and compliance obligations. The study navigates through the complexities of corporate tax regimes, analyzing the implications of tax laws, regulations, and reforms on businesses. Furthermore, it explores the evolving landscape of international taxation and its impact on multinational corporations. The paper also discusses contemporary issues such as tax avoidance, transfer pricing, and tax incentives, shedding light on their implications for corporate taxpayers and tax authorities. Through a comprehensive review of literature and case studies, this research provides valuable insights into the challenges and opportunities associated with corporate taxation, offering recommendations for policymakers, tax practitioners, and corporate entities to navigate the ever-changing tax environment effectively.
Access to Waxes – The Collections from the Arab World of the Berlin Phonogramm-Archiv: Between Digitization, "Repatriation," and Online Publication
Authors: Bahra Nadia , Kirchmair Lando , Pasdzierny Matthias , Wiedmann Albrecht
Published: February 2024

The introduction summarizes the key topics of the themed issue "Access to Waxes – The Collections from the Arab World of the Berlin Phonogramm-Archiv (BPhA)” and its contributions. It discusses the ethical, legal, and technical considerations involved in making these culturally significant but also sensitive recordings from the Arab world accessible to the public, especially in the context of ongoing debates around “decolonization” and cultural restitution.
AI in Healthcare: Revolutionizing Patient Care with Predictive Analytics and Decision Support Systems
Authors: Carrasco Ramírez José Gabriel
Published: February 2024

This article explores the transformative impact of Artificial Intelligence (AI) in healthcare, with a specific focus on how predictive analytics and decision support systems are revolutionizing patient care. Predictive analytics enable early disease prevention and diagnosis by identifying patterns and risk factors, contributing to improved patient outcomes and cost-effective healthcare. Machine learning facilitates personalized treatment plans, leveraging individual patient data for tailored interventions that enhance efficacy and minimize adverse effects. AI-driven algorithms in medical imaging enhance diagnostic accuracy, providing rapid and precise assessments. Decision support systems, powered by AI, streamline healthcare workflows by offering real-time insights based on patient data and clinical guidelines, facilitating evidence-based decision-making. Remote patient monitoring, facilitated by AI, allows for proactive healthcare interventions by tracking vital signs and identifying potential health issues in real time. The article also discusses challenges and ethical considerations associated with AI integration in healthcare, emphasizing the importance of responsible deployment and regulatory frameworks. The comprehensive exploration underscores how AI is not only transforming patient care but also shaping the future of healthcare delivery.
Prenatal diagnosis of congenital adrenal hyperplasia due to 21-hydroxylase deficiency through molecular genetic analysis of the CYP21A2 gene
Authors: Yoon Ji-Hee , Hwang Soojin , Kim Ja Hye , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho
Published: February 2024

Purpose: Deficiency of 21-hydroxylase (21-OHD) is an autosomal recessively inherited disorder that is characterized by adrenal insufficiency and androgen excess. This study was performed to investigate the clinical utility of prenatal diagnosis of 21-OHD using molecular genetic testing in families at risk.Methods: This study included 27 pregnant women who had previously borne a child with 21-OHD. Fetal tissues were obtained using chorionic villus sampling (CVS) or amniocentesis. After the genomic DNA was isolated, Sanger sequencing of CYP21A2 and multiplex ligation-dependent probe amplification were performed. The clinical and endocrinological findings were reviewed retrospectively.Results: A total of 39 prenatal genetic tests was performed on 27 pregnant women and their fetal tissues. The mean gestational age at the time of testing was 11.7 weeks for CVS and 17.5 weeks for amniocentesis. Eleven fetuses (28.2%) were diagnosed with 21-OHD. Among them, 10 fetuses (90.9%) harbored the same mutation as siblings who were previously diagnosed with 21-OHD. Among these, 4 fetuses (3 males and 1 female) identified as affected were born alive. All 4 patients have been treated with hydrocortisone, 9α-fludrocortisone, and sodium chloride since a mean of 3.7 days of life. The male patients did not show hyponatremia and dehydration, although they harbored pathogenic variants associated with the salt-wasting type of 21-OHD.Conclusion: This study demonstrated the diagnostic efficacy and clinical consequences of diagnosis by prenatal genetic testing in families at risk for 21-OHD. All patients identified as affected were treated with hydrocortisone and 9α-fludrocortisone early after birth, which can prevent a life-threatening adrenal crisis.
Effectiveness and safety of pamidronate treatment in nonambulatory children with low bone mineral density
Authors: Lee Myeongseob , Kwon Ahreum , Song Kyungchul , Lee Hae In , Choi Han Saem , Suh Junghwan , Chae Hyun Wook , Kim Ho-Seong
Published: February 2024

Purpose: Nonambulatory pediatric patients may have low bone mineral density (BMD) and increased risk of pathologic fractures. Though bisphosphonate therapy is the mainstream medical intervention in these children, clinical data regarding this treatment are limited. Therefore, this study aimed to evaluate the effectiveness and safety of bisphosphonate therapy in such children.Methods: We conducted a retrospective study of 21 nonambulatory children (Gross Motor Function Classification System level V) with BMD z-score ≤ -2.0 who were treated with intravenous pamidronate for at least 1 year. These patients received pamidronate every 4 months at a dose of 1.0 to 3.0 mg/kg for each cycle and had regular follow-ups for at least 1 year. The main outcome measures were changes in BMD, risk rate of fracture, biochemical data, and adverse events.Results: The average duration of pamidronate treatment was 2.0±0.9 years, and the mean cumulative dose of pamidronate according to body weight was 7.7±2.5 mg/kg/yr. After treatment, the mean lumbar spine bone mineral content, BMD, and height-for-age-z-score-adjusted BMD z-score (BMDhazZ) significantly improved. The relative risk of fracture after treatment was 0.21 (p=0.0032), suggesting that pamidronate treatment reduced fracture incidence significantly. The increase in the average dose per body weight in each cycle significantly increased the changes in BMDhazZ.Conclusion: Pamidronate treatment improved the bone health of nonambulatory children with low bone density without any significant adverse events. Independent of cumulative dosage and duration of treatment, the effectiveness of pamidronate increased significantly with an increase in the average dose per body weight in subsequent cycles.
Genetic evaluation using next-generation sequencing of children with short stature: a single tertiary-center experience
Authors: Kim Su Jin , Joo Eunyoung , Park Jisun , Seol Chang Ahn , Lee Ji-Eun
Published: February 2024

Purpose: We used next-generation sequencing (NGS) to investigate the genetic causes of suspected genetic short stature in 37 patients, and we describe their phenotypes and various genetic spectra.Methods: We reviewed the medical records of 50 patients who underwent genetic testing using NGS for suspected genetic short stature from June 2019 to December 2022. Patients with short stature caused by nongenetic factors or common chromosomal abnormalities were excluded. Thirty-seven patients from 35 families were enrolled in this study. We administered one of three genetic tests (2 targeted panel tests or whole exome sequencing) to patients according to their phenotypes.Results: Clinical and molecular diagnoses were confirmed in 15 of the 37 patients, for an overall diagnostic yield of 40.5%. Fifteen pathogenic/likely pathogenic variants were identified in 13 genes (ACAN, ANKRD11, ARID1B, CEP152, COL10A1, COL1A2, EXT1, FGFR3, NIPBL, NRAS, PTPN11, SHOX, SLC16A2). The diagnostic rate was highest in patients who were small for their gestational age (7 of 11, 63.6%).Conclusion: Genetic evaluation using NGS can be helpful in patients with suspected genetic short stature who have clinical and genetic heterogeneity. Further studies are needed to develop patient selection algorithms and panels containing growth-related genes.
Genetik Algoritma Metodu Kullanılarak Eksenel Alanlı Kalıcı Mıknatıslı Senkron Makinenin Optimal Tasarımı ve Analizi
Authors: PAMUK Nihat
Published: February 2024

Eksenel alanlı kalıcı mıknatıslı senkron makineler yüksek güç yoğunluğu ve karmaşık yapısı olmasından dolayı elektrik sistemi içerisinde önemli avantajlar sunmaktadır ve bu nedenlerle birçok uygulama alanı bulunmaktadır. Senkron makine tasarım sürecinin özü, makine özelliklerinin hızlı, esnek ve doğru hesaplanmasına bağlıdır. Tahrik gereksinimlerini karşılamak ve doğrulamasını gerçekleştirebilmek için elektromanyetik tork analizinin yapılması gerekmektedir. Elektromanyetik tork analizi için birçok farklı yöntem kullanılmaktadır. Bu çalışmada, genetik algoritma optimizasyon teorisi kullanılarak, eksenel alanlı kalıcı mıknatıslı senkron makinenin optimal tasarımı ve analizi gerçekleştirilmiştir. Eksenel alanlı kalıcı mıknatıslı senkron makinenin optimal tasarımı için gerekli olan matematiksel model yapısı oluşturulmuştur. Eksenel alanlı kalıcı mıknatıslı senkron makine tasarımındaki kritik değerlerin belirlenmesine yönelik genetik algoritma optimizasyon yöntemi ile literatürde kullanılan farklı yöntemler birbirleri ile karşılaştırılmıştır. Yapılan çalışmalardan elde edilen sonuçların birbirine yakın olması, makine tasarımındaki kritik değerlerin hesaplanmasında genetik algoritma optimizasyon yönteminin potansiyelini ortaya koymaktadır. Çalışmadan elde edilen genetik algoritma optimizasyon sonuçları ile, eksenel alanlı kalıcı mıknatıslı senkron makinenin optimal tasarımında kullanılan kritik değerlerin daha kolay belirlenebileceği gösterilmiştir.
Estímulos a la internacionalización y criterios de calidad en las universidades de Paraguay
Authors: Oregioni Soledad , Avondet Laura
Published: February 2024

La internacionalización universitaria se ha acelerado y extendido en las últimas décadas en la región latinoamericana. Este proceso de carácter multidimensional, complejo, no neutral y transversal a las funciones sustantivas de la Universidad es estimulado por políticas de promoción y de evaluación que se piensan y desarrollan dentro de marcos estructurales más amplios, que conforman un conjunto de hábitos, presiones y expectativas que inciden en las dinámicas de producción y difusión de conocimiento. El objetivo de este artículo es entender el proceso de internacionalización de las universidades públicas de Paraguay, desde una perspectiva situada, mediante la identificación de sus particularidades y los estímulos que generan las políticas de evaluación, calidad y/o acreditación y la incidencia de las políticas de integración regional a partir de la construcción de estructuras institucionales. Los niveles de análisis empleados son nacional y regional, y se puntualiza en una de sus dimensiones: la relación entre internacionalización de la Educación Superior y los criterios de calidad que se institucionalizaron en el siglo XXI. La hipótesis inicial sobre la que se sustenta el trabajo sostiene que la institucionalidad creada a escala regional ha construido estructuras que disputan sentido a la lógica que emerge del modelo de internacionalización hegemónico.
Reseña. Democracias, justicia social y educación. El legado de Juan Carlos Tedesco
Authors: Amar Hernán Mariano
Published: February 2024

Democracias, justicia social y educación. El legado de Juan Carlos Tedesco es un libro compilado por Silvina Gvirtz y Jorge Steiman, y publicado en la Colección Educación de la UNSAM EDITA. Cuenta con un prólogo escrito por los compiladores y nueve capítulos producidos por especialistas de la educación, como Daniel Filmus, Darío Pulfer y Ana Pereyra, Alejandra Cardini y Axel Rivas, Juan Eduardo García Huidobro, Juan Carlos Geneyro, Inés Dussel, César Coll, Cristián Cox y Pablo Pineau. Contiene, además, una entrevista con testimonios de Nilda León y Sebastián Tedesco, compañera de vida e hijo mayor del educador argentino.
Universidad y desarrollo local: procesos innovadores en el tercer nivel de gobierno
Authors: Suárez Mariano , Robaina Natalie , Del Prado Leonel , Noboa Alejandro
Published: February 2024

El artículo analizará cómo desde la Universidad se pudieron implementar dos políticas públicas participativas desarrolladas en el ámbito municipal de Uruguay: las Agendas Municipales de Cultura y las Agendas Municipales de Desarrollo Territorial. En ambos casos, a través de fondos concursables, el Grupo de Estudios de la Participación y la Descentralización desarrolló procesos participativos que estuvieron promovidos desde la Oficina de Planeamiento y Presupuesto-Presidencia de la República. El texto iniciará enmarcando el trabajo realizado por el equipo de investigadores desde la Universidad como una forma de relacionar la institución con la comunidad y dotarla de un papel activo en la construcción de cohesión social y desarrollo en un nuevo escenario como es el tercer nivel de gobierno. Ello se conecta con una nueva manera de concebir la política pública y el desarrollo anclado en los propios procesos y dinámicas territoriales y, a su vez, potenciarlo con capacidades también situadas en el territorio. Luego, se analizarán ambas experiencias y el rol que se cumplió desde el grupo de investigadores universitarios mediante la consideración de que el propio Grupo de Estudios de la Participación y la Descentralización es producto de la política de descentralización territorial llevada adelante por la Universidad de la República, como uno de los resultados directos del Programa de Fortalecimiento de la Calidad de la Investigación -Comisión Sectorial de Investigación Científica-. Finalmente, se reflexionará sobre el rol de la Universidad y el empleo de estas metodologías de investigación. En este punto, se retomará nuevamente el papel que pueden asumir en este campo la Educación Superior, la investigación y la innovación.
Formación para la docencia médica: resultados y desafíos
Authors: Ocampos Benedetti Sandra , Stark Bernardita , Robledo María del Rocío
Published: February 2024

La FCM-UNA es la escuela de Ciencias de la Salud más antigua del país y la única hasta bien entrado el siglo XX.  En ese carácter ha formado a la mayoría de los médicos paraguayos que han venido ejerciendo la docencia en la propia escuela y en las demás que se han ido abriendo en todo el país. De esa forma, ha instalado un modelo de docencia propio de referencia para la docencia médica paraguaya.  Este antecedente ha llevado a la reflexión acerca de la actualización curricular hacia un currículum orientado por competencias, que requiere adecuación a las teorías pedagógicas y una práctica docente diferente a la tradicional. En ese marco, incluso, se han hecho prácticas formativas con los estudiantes, para desarrollar competencias docentes en los egresados de la escuela.  En la situación de pandemia por Covid-19, los escenarios docentes fueron violentamente transformados, tanto por la alta demanda de profesionales de la salud para atender la pandemia, como por la transformación en la didáctica de clase virtuales y de prácticas hospitalarias.  En el artículo se analizan los resultados alcanzados por el trabajo de adecuación curricular desde el inicio de su implementación en 2017, su paso por la pandemia desde 2020 y los desafíos inmediatos y futuros para una profesión altamente demandada, con compromisos éticos y humanitarios, que puede llevar al límite de la salud mental a los profesionales.
Universidad para el desarrollo en Uruguay: construcción de capacidades académicas en respuesta a necesidades locales y nacionales
Authors: Heinzen Margarita , Bortagaray Isabel
Published: February 2024

La pandemia generada por COVID-19 ha expuesto y reforzado con mayor crudeza las desigualdades existentes entre países centrales y periféricos. También ha evidenciado la relevancia de las capacidades de producción de conocimiento acumuladas en estos países, y su rol fundamental para afrontar la crisis. En Latinoamérica no existen sectores productivos que sean fuertes demandantes de investigación y conocimiento local. Es en las universidades públicas donde se concentran estas capacidades y donde se han puesto en marcha procesos para responder a los desafíos del desarrollo humano sustentable. En Uruguay, la Universidad de la República (UdelaR) impulsó una serie de políticas transformadoras entre 2007 y 2014, con el fin de acercar la institución a los nuevos tiempos de la Educación Superior (ES), bajo una concepción de “Universidad para el desarrollo”. Una de las líneas de esta reforma universitaria fue la de la expansión territorial hacia el interior del país, basada en: i) nuevas institucionalidades en distintas regiones (CENURes); ii) Programas de Enseñanza Terciaria (PRET) que dieran cuenta de las necesidades y diversidades socioproductivas locales y; iii) Polos de Desarrollo Universitario (PDU), entendidos como grupos docentes de alta dedicación para desarrollar enseñanza de grado y posgrado, investigación y extensión en torno a ejes temáticos pertinentes y relevantes a cada región. Se entiende que los grupos PDU fueron la herramienta que permitió aterrizar la política para crear masa crítica, viabilizar la demanda social de territorios concretos, así como para introducir cambios institucionales en varios niveles. Este trabajo intenta aportar a la comprensión de las dinámicas de construcción de capacidades, con énfasis en la producción académica de estos grupos, sus agendas y la vinculación entre estas y el contexto, a través de la trayectoria del polo de Virología que se instaló en la sede de Salto de la Universidad de la República. Busca también utilizar este estudio de caso para aportar a la reflexión sobre la “Universidad para el Desarrollo”. Diez años después de su creación, con un entramado científico-tecnológico establecido en el territorio, este grupo académico ha mostrado su relevancia tanto en relación con la generación como en el uso innovador de conocimiento original en el contexto de la pandemia causada por el COVID-19
El sistema universitario argentino y los desafíos post-COVID19
Authors: Suárez Diana , Barletta Florencia , Yoguel Gabriel
Published: February 2024

Este ensayo propone una reflexión en torno al rol de las universidades argentinas y el sistema nacional de Ciencia y Tecnología (CyT) del que son parte. Nos interesa profundizar sobre tres aspectos claves y sobre las particularidades bajo las que ese rol se manifiesta en el caso argentino, cuando se abordan los desafíos del desarrollo. En primer lugar, el esquema institucional sobre el que se basa el sistema universitario, que forma parte del sistema de CyT nacional y que concentra a la gran mayoría de la actividad científico-tecnológica que se produce en el país. En segundo lugar, los incentivos y prácticas que moldean las trayectorias de la comunidad científica y tecnológica, donde se combinan actividades de CyT con la docencia de pregrado, grado y posgrado. En tercer lugar, la demanda de conocimiento, tanto en términos del entorno productivo como aquella derivada de los aspectos sociales y de la política pública. Un “engranaje” virtuoso de estos tres aspectos requiere gestionar las características y los tiempos de cada una de las dimensiones y generar un proceso de reformas en los esquemas de incentivos y entramado institucional para lograr que los casos de éxito, que hoy existen de manera aislada, se multipliquen y articulen con el sistema nacional más amplio, que abarca además funciones no tradicionales de la CyT. El mundo post-COVID19 abre un espacio para repensar las prácticas académicas y de formación y modificar las estructuras de vinculación y articulación de la academia con la sociedad.
¿Qué universidad después de la pandemia?
Authors: Sánchez Martínez Eduardo
Published: February 2024

En este breve artículo, el autor aporta algunas reflexiones para repensar el perfil de Universidad que se debiera ir definiendo desde ya para después de la pandemia. Ese perfil estará fuertemente definido por las características y calidad del proceso de enseñanza y aprendizaje que cada institución logre desarrollar. Entre otros factores, en ello tendrá seguramente una ponderable incidencia la estrategia de hibridación entre modalidades que se adopte, así como su alcance, intensidad, conveniencia pedagógica, y momento o fase del proceso de formación en que se introduzca o trabaje.
Analysis Of The Role Of Kpai To Protect Violence Against Children
Authors: Ansori Maulana  , Lidya Rahmadhani Hasibuan
Published: February 2024

KPAI is a state institution whose special task is to supervise the implementation of child protection in Indonesia, which is an obligation that must be upheld and implemented by the laws of the Republic of Indonesia. Violence is a mere behavior carried out by someone against another person to cause psychological or physical harm or injury. Punishment is not only expected to provide a deterrent sanction against the perpetrator. This research uses a normative juridical approach because the author only studies and analyzes based on previously existing cases obtained either from books, journals, or online media which are then analyzed according to the data. This writing focuses on legal protection for children in cases of violence in Indonesia. We as a society or parents must protect children from perpetrators who are victims of violence. The perpetrator always has a way to commit a crime. If the perpetrator of a crime of violence is caught, punish the perpetrator as harshly as possible, and for victims who experience violence, here too the victim also experiences mental pressure and severe trauma. You also have to help with treatment so that the child becomes confident again and can carry out the activities they normally do. Violence perpetrated against a child has several impacts, such as the child becoming disturbed in his/her education, the child becoming aggressive and even dying due to the physical damage experienced by the child. To reduce the level of violence against children, it is necessary to raise the age limit for marriage for children. Because the ideal marriage age for women is 21 years and for men 24 years, the data was obtained from the BKKBN campaign so that families grow up.
Síndrome de Guillain-Barré – uma revisão bibliográfica
Authors: De Oliveira Jefferson Borges , Ribeiro Maria Eduarda Bresolin , De Toledo Ana Renata Pinto
Published: February 2024

A Síndrome de Guillain-Barré (SGB) é uma polineuropatia desmielinizante inflamatória aguda, de etiologia desconhecida, caracterizada por paresia ou paralisia flácida que atinge mais de um membro, frequentemente simétrica, associada à arreflexia e aumento de proteínas no líquor, sem pleocitose. Geralmente, infecções respiratórias, disfunções motoras ou cirurgias, precedem os sintomas neurológicos, num período aproximado de 5 dias a 3 semanas. Os sinais e sintomas envolvem fraqueza simétrica rapidamente progressiva, abolição dos reflexos tendinosos, diplegia facial, paresia orofaríngea e respiratória e distúrbio da sensação nas mãos e pés. Essa condição piora durante alguns dais a 3 semanas, quando então se estabiliza e depois há uma melhora gradual até a função normal ou quase normal. Sua terapêutica engloba o uso de plasmaférese ou infusão de altas doses endovenosas de imunoglobulina humana; ambas possuem eficácia semelhante, sendo que a imunoglobulinoterapia é de mais fácil realização, melhor tolerada, além de apresentar menor índice de riscos e complicações. Este trabalho tem como objetivos realizar uma revisão bibliográfica sobre o tema, apresentando um breve histórico sobre a doença, bem como sua conceituação, incidência, etiologia, patogenia, manifestações clínicas, diagnóstico, descrevendo os subtipos da SGB e entre eles a Síndrome de Miller Fisher (SMF), além do diagnóstico diferencial, do qual a desmienilização ascendente ocasionada por intoxicação por organofosforados faz parte. Por esse motivo, a fim de enriquecer ainda mais esse estudo, optou-se por descrever um caso clínico de um paciente com o quadro de intoxicação por organofosforados, apresentando as características do quadro. Pode-se concluir que Entre as modalidades de tratamento mais efetivas estão a plasmaferese e a infusão endovenosa de imunoglobulina em altas doses, ambas com eficácia semelhante, porém a imunoglobulinoterapia possui menor índice de complicações. Além disso, a intervenção de uma equipe multidisciplinar capacitada para reabilitação do paciente também é de fundamental importância, sendo que uma avaliação terapêutica motora abrangente se faz necessária a fim de certificar-se do grau de força muscular e ADM antes do início do tratamento; durante e após a reabilitação, a intervenção motora efetiva diminui as complicações respiratórias, cardíacas e vasculares. E mesmo diante da gravidade do quadro, a SGB apresenta um bom prognóstico, com a maioria dos casos se recuperando por completo e somente um pequeno número evolui para o óbito.