bluuebunny/crossref_metadata_2025 huggingface dataset:
Rare Clinical Case of Cryopyrin-associated Periodic Syndrome Presented
with Ankylosing Spondylitis: A Case Report
Authors: Kulanthaivel Shanmugaraj , Zayaeva Anna A. , Sokolova Lyudmila V. , Shaduro Denis V. , Petrov Andrey V. , Kaliberdenko Vitalii B.
Published: November 2021

Background:

Cryopyrin-Associated Periodic Syndrome (CAPS) is a variety of clinical
variants of autoinflammatory diseases. The pathology is based on a mutation in the NLRP3 gene
encoding the cryopyrin protein, which leads to the uncontrolled production of interleukin-1β. Particular
attention should be paid to the rarity of this disease and the lack of clinical knowledge about
it in therapeutic and rheumatological practice, which leads to an erroneous diagnosis and the appointment
of ineffective treatment for a long time, leading to the progression of the disease and disability
of the patient.

Case Presentation:

This article describes a clinical case of this disease. The first manifestations of
the disease in a woman appeared from the age of 2 years, in the form of a rash and fever. Since
school age, there have been signs of arthritis. By the age of 24, sensorineural hearing loss and pain
in the spine were evident. The disease occurred under the clinical manifestations of spondyloarthritis.
Its treatment with anti-inflammatory therapy did not give a stable result.

Conclusion:

From the analysis, we can conclude that patient M. from early childhood suffers from
a severe Neonatal-onset Multisystem Inflammatory Disease of a genetic nature. For a long time,
the patient was diagnosed with ankylosing spondylitis, and appropriate treatment was carried out
without significant success. The correct diagnosis of CAPS was made only in 2018. This patient
has conditions of both CAPS and AS together, which is a very rare association in rheumatological
practice. The only treatment method that could stop the manifestations of the disease and prevent
life-threatening kidney damage (amyloidosis) is the use of genetically engineered biological drugs,
i.e., IL-1β inhibitors. The only drug of this group registered in Russia is canakinumab (Ilaris®).
From the moment of diagnosis to the present day, the patient is treated with the genetically engineered
drug canakinumab (Ilaris®) at a dose of 150 mg once every 8 weeks. 6 months after taking
the drug, the patient went into complete clinical and laboratory remission.
Discovery of a Novel Small-molecule Interleukin-6 Inhibitor Through
Virtual Screening Using Artificial Intelligence
Authors: Sato Yoshiaki , Kashiwakura Ikuo , Yamaguchi Masaru , Yoshino Hironori , Tanaka Takeshi , Ikeda Ken , Ye Zhengmao , Komatsu Hirotsugu , Matsuzaki Takao , Hosoda Masato
Published: November 2021

Background:

Interleukin-6 (IL-6) is a multifunctional cytokine involved in various cell
functions and diseases. Thus far, several IL-6 inhibitors, such as humanized monoclonal antibody
have been used to block excessive IL-6 signaling causing autoimmune and inflammatory diseases.
However, anti-IL-6 and anti-IL-6 receptor monoclonal antibodies have some clinical disadvantages,
such as a high cost, unfavorable injection route, and tendency to mask infectious diseases. While a
small-molecule IL-6 inhibitor would help mitigate these issues, none are currently available.

Objective:

The present study evaluated the biological activities of identified compounds on IL-6
stimulus.

Methods:

We virtually screened potential IL-6 binders from a compound library using INTerprotein’s
Engine for New Drug Design (INTENDD®) followed by the identification of more potent IL-6
binders with artificial intelligence (AI)-guided INTENDD®. The biological activities of the identified
compounds were assessed with the IL-6-dependent cell line 7TD1.

Results:

The compounds showed the suppression of IL-6-dependent cell growth in a dose-dependent
manner. Furthermore, the identified compound inhibited expression of IL-6-induced phosphorylation
of signal transducer and activator of transcription 3 in a dose-dependent manner.

Conclusion:

Our screening compound demonstrated an inhibitory effect on IL-6 stimulus. These
findings may serve as a basis for the further development of small-molecule IL-6 inhibitors.
Novel 2-Nitroimidazole and Imidazooxazole Derivatives and their Activity against Trypanosoma cruzi and Mycobacterium tuberculosis
Authors: Faria Jessica V. , Passos Fernanda P.Z. , da Costa Paulo H.A. , de Oliveira Andressa P. , Cruz Yasmin O.D. da , Castelo-Branco Frederico S. , Lourenço Maria C.S. , Murta Silvane M.F. , Junior Policarpo A.S. , Bernardino Alice M.R. , Bastos Monica M. , Boechat Nubia
Published: November 2021

Background:

Tuberculosis (TB) is one of the top ten causes of death worldwide, while
Chagas disease (CD) is the parasitic disease that kills the largest number of people in the Americas.
TB is the leading cause of death for patients with AIDS; it kills 1.5 million people and causes 10
million new cases every year. The lack of newly developed chemotherapeutic agents and insufficient
access to health care services for a diagnosis increase the incidence of multidrug-resistant TB (MDRTB)
cases. Although CD was identified in 1909, the chronic stages of the disease still lack adequate
treatment.

Objective:

The purpose of this work was to design and synthesize two new series of 2-nitroimidazole
5a-e and imidazooxazoles 6a-e with 1H-1,2,3-triazolil nucleus and evaluate their activities against Tc
and Mycobacterium tuberculosis (Mtb).

Methods:

Two series of five compounds were synthesized in a 3 or 4-step route in moderated yields,
and their structures were confirmed by NMR spectral data analyses. The in vitro antitrypanosomal
evaluation of products was carried out in an intracellular model using L929 cell line infected with
trypomastigotes and amastigote forms of Tc of β-galactosidase-transfected Tulahuen strain. Their
antimycobacterial activity was evaluated against Mtb strain H37Rv.

Results:

In general, 2-nitroimidazolic derivatives proved to be more potent in regard to antitrypanocidal
and antimycobacterial activity. The non-cytotoxic 2-nitroimidazole derivative 5b was the most
promising with a half maximum inhibitory concentration of 3.2 μM against Tc and a minimum inhibitory
concentration of 65.3 μM against Mtb.

Conclusion:

Our study reinforced the importance of 2-nitroimidazole and 1H-1,2,3-triazole nuclei in
antimicrobial activity. In addition, derivative 5b proved to be the most promising, presenting important
activity against Tc and Mtb and could be used as a starting point for the development of new
agents against these diseases.
Information needs for Inclusion in a Post-Discharge Guideline Booklet for Mothers with Prematurely born Babies in a Low-Resource Setting in South Africa
Authors: Sengane Malmsey L.M. , Maree Carin , Niekerk Louise René van
Published: November 2021

Background:

Prematurity brings along a high risk of early and late mortality and morbidity that demands specialized care within the NICU. Mothers of premature babies often feel powerless and helpless once the premature baby is discharged from the neonatal intensive care unit (NICU). These experiences might interfere with their transitions into parenthood as they might question their ability to care for their baby. As nurses become greatly concerned regarding the continuity of care at home, the purpose of this study was to explore and describe the information that mothers of prematurely born babies need upon discharge for inclusion in a guideline booklet.

Methods:

A qualitative explorative design was used to conduct interviews with mothers of prematurely born babies in a NICU of a tertiary hospital in Gauteng Province, South Africa. Purposive sampling was used to select mothers whose prematurely born babies were preparing for discharge from NICU and mothers whose babies were discharged and at home and were brought to the hospital for their six weeks follow-up after discharge. Unstructured individual interviews were conducted.

Results:

The following seven themes were identified, namely feeding of a prematurely born baby, positioning of the baby, infection control and hygiene, care for a sick baby or baby with special needs, immunisation and clinic visits, normal development and growth, and information guidelines.

Conclusion:

The findings of this study were used to include essential information in a guideline booklet for mothers with prematurely born babies upon discharge from the NICU.
Patients’ Satisfaction with Services Offered by Nurses at a Selected Ideal Clinic in Ehlanzeni District, Mpumalanga Province, South Africa
Authors: Nkabinde Nompumelelo P. , Bopape Mamare A. , Mothiba Tebogo M. , Mphekgwana Peter M.
Published: November 2021

Background:

The patients mainly determine if the services they are offered are useful, effective, or beneficial to them. Moreover, quality health care provision is a global concern. Most importantly, although several studies have been done globally on patients’ satisfaction, however, it remains an issue for scientific investigation, especially in South Africa, as patients’ satisfaction evaluation, specifically in a primary health care setting, is still a subject under-research.

Aim/Purpose:

This study sought to identify and describe factors contributing to patients’ satisfaction with services offered by nurses in an ideal clinic.

Methods:

The study conducted a quantitative, descriptive, cross-sectional study with a sample size of 114 patients from a population of 160 responding to a close-ended questionnaire, and the data were analysed using SPSS descriptive statistics.

Results:

The majority of patients in the study were females between the age of 18 and 29 years. The nurses have satisfied about 87.8% of the patients (n = 100), as they were satisfied with the care they were provided, while 88.6% (n = 101) agreed that they would come back to the clinic as they were offered good services. About 64.8% (n = 74) have indicated that they would recommend the clinic to others. Thus, by using the Chi-Square test, factors, such as the time taken to provide services, privacy, nurses' conduct, knowledge, and abilities, were found to have an impact on patients’ satisfaction.

Conclusion:

The study revealed that largely, the patients at the clinic in Ehlanzeni District, Mpumalanga Province, South Africa, were satistfied with the care the nurses rendered. In conclusion, the following factors contribute to patients’ satisfaction with services offered by nurses in selected ideal clinics: marital status, privacy, time, nurses' conduct (friendly, polite, listening), the information given to patients, patient-centred care (involving patients in their care, allowing questions and suggesting alternative treatment or giving opinions and having a say in their care), and nurses’ knowledge and abilities.
Virtual boarding school education management
Authors: Mursidi Agus , Kamal M. , Noviandari Harwanti , Agustina Nurul , Nasyafiallah M. Haddadalwi
Published: November 2021

If general education has been implemented virtually, there is nothing wrong with the same method applied by Islamic education or Islamic boarding schools. For this reason, we will look for data to strengthen this discussion to propose a virtual boarding school education system which is the idea of ??equal distribution of educational services to the millennial generation from house to house. We collect data online on published journals, books, proceedings, and websites that address virtual boarding school education issues. Furthermore, the collected data is analyzed using a coding system, comprehensive evaluation, and drawing conclusions that can answer the main problems of this project. By analyzing and discussing the data, we can conclude that virtual boarding school education is an exciting idea with efforts to distribute Islamic education services to the millennial generation, who happen to be not santri.
The Role of Electronic Medical Records in Reducing Unwarranted Clinical Variation in Acute Health Care: Systematic Review
Authors: Hodgson Tobias , Burton-Jones Andrew , Donovan Raelene , Sullivan Clair
Published: November 2021

Background

The use of electronic medical records (EMRs)/electronic health records (EHRs) provides potential to reduce unwarranted clinical variation and thereby improve patient health care outcomes. Minimization of unwarranted clinical variation may raise and refine the standard of patient care provided and satisfy the quadruple aim of health care.

Objective

A systematic review of the impact of EMRs and specific subcomponents (PowerPlans/SmartSets) on variation in clinical care processes in hospital settings was undertaken to summarize the existing literature on the effects of EMRs on clinical variation and patient outcomes.

Methods

Articles from January 2000 to November 2020 were identified through a comprehensive search that examined EMRs/EHRs and clinical variation or PowerPlans/SmartSets. Thirty-six articles met the inclusion criteria. Articles were examined for evidence for EMR-induced changes in variation and effects on health care outcomes and mapped to the quadruple aim of health care.

Results

Most of the studies reported positive effects of EMR-related interventions (30/36, 83%). All of the 36 included studies discussed clinical variation, but only half measured it (18/36, 50%). Those studies that measured variation generally examined how changes to variation affected individual patient care (11/36, 31%) or costs (9/36, 25%), while other outcomes (population health and clinician experience) were seldom studied. High-quality study designs were rare.

Conclusions

The literature provides some evidence that EMRs can help reduce unwarranted clinical variation and thereby improve health care outcomes. However, the evidence is surprisingly thin because of insufficient attention to the measurement of clinical variation, and to the chain of evidence from EMRs to variation in clinical practices to health care outcomes.
A Multimodal Messaging App (MAAN) for Adults With Autism Spectrum Disorder: Mixed Methods Evaluation Study
Authors: Hijab Mohamad Hassan Fadi , Al-Thani Dena , Banire Bilikis
Published: November 2021

Background

Individuals with autism spectrum disorder (ASD) often exhibit difficulties in social and communication skills. For more than 30 years, specialists, parents, and caregivers have used techniques, such as applied behavioral analysis, augmentative and alternative communication, and the picture exchange communication system to support the social and communication skills of people with ASD. Even though there are many techniques devised to enhance communication, these techniques are not considered in existing social media apps for people with ASD.

Objective

This study aimed to investigate the effect of adding accessibility features, such as text-to-speech (TTS), speech-to-text (STT), and communication symbols (CS), to a messaging app (MAAN). We hypothesized that these accessibility features can enhance the social and communication skills of adults with ASD. We also hypothesized that usage of this app can reduce social loneliness in adults with ASD.

Methods

Semistructured interviews were conducted with 5 experts working in fields related to ASD to help design the app. Seven adults with ASD participated in the study for a period of 10 to 16 weeks. Data logs of participants’ interactions with the app were collected. Additionally, 6 participants’ parents and 1 caregiver were asked to complete a short version of the Social and Emotional Loneliness Scale for Adults (SELSA-S) questionnaire to compare pre-post study results. The Mobile Application Rating Scale: user version questionnaire was also used to evaluate the app’s usability. Following the study, interviews were conducted with participants to discuss their experiences with the app.

Results

The SELSA-S questionnaire results showed no change in the family subscale; however, the social loneliness subscale showed a difference between prestudy and poststudy. The Wilcoxon signed-rank test indicated that poststudy SELSA-S results were statistically significantly higher than prestudy results (z=−2.047; P=.04). Point-biserial correlation indicated that the SELSA-S rate of change was strongly related to usage of the TTS feature (r=0.708; P=.04) and CS feature (r=−0.917; P=.002), and moderately related to usage of the STT feature (r=0.428; P=.17). Lastly, we adopted grounded theory to analyze the interview data, and the following 5 categories emerged: app support, feature relevance, user interface design, overall feedback, and recommendations.

Conclusions

This study discusses the potential for improving the communication skills of adults with ASD through special features in mobile messaging apps. The developed app aims to support the inclusion and independent life of adults with ASD. The study results showed the importance of using TTS, STT, and CS features to enhance social and communication skills, as well as reduce social loneliness in adults with ASD.
NEUROPHARMACOLOGICAL SCREENING, ANTI-STRESS ACTIVITY, AND TOXICITY STUDIES OF STANDARDIZED EXTRACT OF THE SEEDS OF CELASTRUS PANICULATUS WILLD
Authors: SINGH SWATI , UPADHYAY ASHUTOSH , KUMAR SIRBAIYA ANUP
Published: November 2021

Objective: Celastrus paniculatus Willd, family Celastraceae is an important medicinal plant distributed all over India. Due to the presence of antioxidative polyphenols in C. paniculatus Willd have received much attention for health-promoting properties by scavenging the free radicals, the purpose of this study is to understand neuropharmacological, anti-stress activity, and toxicity studies of standardized seeds extract of “C. paniculatus Willd. Methods: The sun dried C. paniculatus Willd seeds were collected and extracted with ethanol by maceration. Then, the ethanolic extract was subjected to phytochemical screening. The acute toxicity of the ethanolic extract of C. paniculatus was observed as per the Organization for Economic Co-operation and Development guideline no. 423. Neuropharmacological and anti-stress effects were analyzed and evaluated by using physical stress models such as Swimming endurance test, Anoxic tolerance test, Tail suspension test (TST), and Elevated plus maze test. For this study, Swiss albino mice (20–30 g) were divided into five groups of six animals each. Distilled water administered as vehicle in control group and standard group received Withania somnifera (100 mg/kg) while C. paniculatus Willd ethanolic extract (100, 200, and 400 mg/kg) was given orally for 7 days. Results and Discussion: Change in immobility time in swim endurance, first clonic convulsion produced in anoxic tolerance test, immobility time in TST and open arms entry in elevated plus maze test was recorded as parameters. The ethanolic extracts of C. paniculatus Willd significantly reduces the immobility timing along with increases the swimming endurance time, and clonic convulsion timing in anoxic tolerance test in comparison of control group. In tail suspension significant decrease in immobility time and increased open arm entry in elevated plus maze were observed as compare to control group. Conclusion: C. paniculatus Willd has potential as a medicinal plant and it showed protective effect for the stress prevention as the alkaloids are present as main constituents.
A PRAGMATIC APPROACH TO TREAT LUNG CANCER THROUGH LOADING THEAFLAVIN -3,3’-DIGALLATE AND EPIGALLOCATECHIN GALLATE IN SPANLASTIC
Authors: IMAM SYED SAIF , AGARWAL SMRITI
Published: November 2021

Lung cancer has the highest mortality rate as compared to other cancers. The anti-proliferative and antioxidant potential of epigallocatechin gallate (EGCG) and Theaflavin -3,3’-digallate (TF3) can play a major role in treatment if delivered efficiently. To improve the chemical stability and medicinal potential of EGCG and TF3 in the respiratory tract, a spanlastic is developed which is composed of Tween-80, Span-60, and cholesterol which encapsulate EGCG and TF3 inside its vesicular structure and deliver it specifically to the target cancer cells. The cholesterol layer will produce efficient penetration while tween-80 and span-60 will help in easily deformability and lowers the interfacial tension hence, produces a small Z-average diameter which facilitates efficient penetration between layers of cells. The nano-vesicular structure ensures the APIs stability at alkaline pH (7.6) and also increases cellular antioxidant activity and Ferric reducing antioxidant powers values of APIs. Better encapsulation efficiency and safe consideration by MTT assay are major advantages of Spanlastic. The lung cancer cell loses the ability of apoptosis, which can revived with the help of a nano-vesicular system of EGCG and TF3 and in addition, there will be activation of several other properties such as cell arrest, activation of miR-210, suppression of cyclin D1, inhibition of MAPK, ERK, and JAK-STAT at their maximum potential. Furthermore, a special type of spacer and pMDI canister are developed in order to maximize the drug stability and efficiency of its delivery.
EFFICACY OF TERIPARATIDE IN COMMINUTED FRACTURE HEALING IN LOWER LIMB: A RETROSPECTIVE STUDY
Authors: DUDHIA SNEH , MAHAJAN KETAS
Published: November 2021

Objective: The objective of the study was to show the efficacy of teriparatide in comminuted fracture healing and improvement in overall functional recovery.
Methods: A total of 30 subjects who suffered from comminuted fractures of lower limb were selected. Subjects were categorized into two groups: Group A (n=15) contained individuals with teriparatide administration and Group B (n=15) contained individuals who were not administered teriparatide. 20 mg of teriparatide was injected subcutaneously for a period of 3 months. Patients were followed up ay durations of 4, 8, and 12 weeks. Obtained data were entered into Microsoft Excel Worksheets and descriptive analysis was performed. Chi-square test was used to analyze all obtained data.
Results: Among Group A patients, the fracture healing rates were found to be significantly earlier with comparison to control group (Group B).
Conclusion: Teriparatide was observed to be effective in comminuted fracture healing and has demonstrated good clinical outcome.
АППАРАТНО-ПРОГРАММНАЯ РЕАЛИЗАЦИЯ АЛГОРИТМА ВИТЕРБИ НА БАЗЕ DSP-ЯДРА ELCORE-30MV
Authors: Александров Ю.Н. , Беляев А.А. , Кузнецов Д.А. , Петричкович Я.Я. , Солохина Т.В. , Кучинский А.С. , Фролов А.А.
Published: November 2021

Дается описание аппаратно-программной реализации алгоритма Витерби на уровне системы инструкций DSP-ядра Elcore-30MV. Рассматриваются возможности поддержки различных режимов декодирования, в том числе турбодекодера. Представлены результаты моделирования алгоритма при различных режимах работы декодера и уровнях искажений передаваемых данных.
ИНФОРМАЦИОННО-УПРАВЛЯЮЩАЯ СИСТЕМА ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ С НАРУШЕНИЯМИ ФУНКЦИИ ГОРТАНИ
Authors: Телышев Д.В. , Нестеренко И.В. , Мамекин К.А.
Published: November 2021

Разработана новая информационно-управляющая система для обеспечения спонтанного дыхания при парезе голосовых связок с помощью прямой электрической стимуляции задней перстнечерпаловидной мышцы.
К ВОПРОСУ СОЗДАНИЯ ИНТЕЛЛЕКТУАЛЬНОЙ ДЕЦЕНТРАЛИЗОВАННОЙ ЭНЕРГОНАКОПИТЕЛЬНОЙ СИСТЕМЫ
Authors: Лустгартен М.Ю. , Собченко М.И. , Ухандеев В.И.
Published: November 2021

В статье рассмотрены подходы к управлению энергетическими системами с помощью нейронных сетей. Предложен подход к управлению балансировкой аккумуляторов. Приведена архитектура масштабируемого энергонакопительного модуля.
ОБЕСПЕЧЕНИЕ ПОВЫШЕНИЯ КАЧЕСТВА УПРАВЛЕНИЯ - КЛЮЧЕВОЙ ФАКТОР РЕШЕНИЯ ЗАДАЧИ УСКОРЕНИЯ ТЕМПА РАЗВИТИЯ МИКРОЭЛЕКТРОНИКИ
Authors: Медвехкв Н.С.
Published: November 2021

Описаны связанные с интеграцией технологий перспективы развития информационно-управляющих систем. Указано на превалирующую роль вопросов организации. Предложено расширение требований и мер поддержки к заявителям для повышения качества управления инновационными проектами в области микроэлектроники.
ОПРЕДЕЛЕНИЕ ПРЕДЕЛЬНОГО ЗНАЧЕНИЯ РАБОЧЕЙ ЧАСТОТЫ СИСТЕМЫ ЧРЕСКОЖНОЙ ИНДУКТИВНОЙ ПЕРЕДАЧИ ЭНЕРГИИ МОЩНОСТЬЮ 10 ВТ
Authors: Рябченко Е.В. , Дьячкова Е.С. , Данилов А.А.
Published: November 2021

Проведена серия численных расчетов электромагнитных полей, индуцируемых при работе систем индуктивной чрескожной передачи энергии в диапазоне 200-2000 кГц. По результатам моделирования определена предельно допустимая рабочая частота системы чрескожной передачи энергии с выходной мощностью 10 Вт.
Cascaded PID Control System for UAV with Gain Factor Prediction Using ML
Authors: Goje Shubhankar
Published: November 2021

Abstract: Drones are not inherently stable, necessitating the use of a flight controller. If the UAV is properly tuned, the drone will fly steadily; otherwise, it won’t. Hence, we have used a PID (proportional, integral, differential) controller for a stable flight. A well-functioning PID controller should enable amazing climbs and long-range flights. But, when used singly, PID controllers can provide poor performance, resulting in a long settling time, overshoot, and oscillation. Here, we propose a new approach to maneuver UAVs using a PID control system and overcome the shortcomings of using PID controllers in UAVs. This disadvantage is resolved using the Machine Learning polynomial regression model. The gain factors in a PID control system, which is otherwise ideally constant, should be changed in order to reduce the minor instabilities for a smooth flight. Our method has been elaborated and illustrated with suitable diagrams in the following work. When simulated in Gazebo on a Robot Operating System (ROS), our technique is proven to be successful. Keywords: Control Systems, PID, UAV, Drones, Polynomial Regression, Gain Factor, Prediction Algorithm.
Dificuldades enfrentadas pelos usuários para resolubilidade do cuidado oftalmológico na rede de atenção à saúde
Authors: Meneguin Silmara , Pollo Camila Fernandes , Oliveira Ines Regina Mainini
Published: November 2021

Marco contextual: A resolubilidade da assistência à saúde é um conceito associado à resolução final dos problemas trazidos pelos usuários ao serviço de saúde. Objetivos: Conhecer os motivos que dificultam a resolubilidade do cuidado oftalmológico na atenção secundária de atenção à saúde, sob a perspectiva do usuário e identificar sugestões de melhoria para a mesma. Métodos: Trata-se de uma pesquisa quali-quantitativa, realizada com uma amostra não probabilística de 208 pacientes, que receberam indicação de cuidado oftalmológico em unidade de atenção secundária de saúde, de município do interior de São Paulo. As entrevistas foram gravadas, após consentimento dos participantes, transcritas e analisadas utilizando-se a estratégia metodológica do Discurso do Sujeito Coletivo. Resultados: Os motivos que atrasam a resolubilidade do cuidado são inúmeros e estão atrelados à burocracia, falta de recursos humanos e materiais, bem como inexistência da referência e contrarreferência na organização da rede de atenção à saúde. Conclusão: As dificuldades sentidas pelos usuários refletem a falta de organização desse serviço, que além de não priorizar o atendimento aos pacientes diabéticos. também não se compromete com o devido encaminhamento e acompanhamento.
Avaliação e características das quedas de pacientes durante a internação hospitalar
Authors: Dornelles Cristian , De Aguiar Joycianne Ramos Vasconcelos , De Matos Mariana Bonati , Ferreira Lidiane Aguiar , Cecagno Susana , Prado Athaynne Ramos de Aguiar
Published: November 2021

Objetivo: Avaliar e caracterizar as quedas de pacientes em um hospital no sul do Brasil. Método: Estudo descritivo e retrospectivo de 73 notificações de quedas em um hospital no sul do Brasil, de janeiro 2016 a dezembro de 2019. Utilizou-se dados secundários obtidos pelo Núcleo de Segurança do Paciente da instituição e da Morse Fall Scale, sendo a análise estatística descritiva. Resultados: A maioria dos pacientes que sofreram quedas foi do sexo masculino (60,3%), >61 anos (50,6%), tratamento clínico (89,0%), portadores de neoplasias (43,8%) em uso contínuo de medicações (91,8%). As quedas ocorreram da própria altura (67,1%), no banheiro (56,2%) e no turno da noite (50,0%). Em 50,7% das quedas houve danos ao paciente, sendo os danos considerados como: leve (62,2%), moderado (32,4%) e grave (5,4%). Conclusão: Melhorar a compreensão das quedas e as suas consequências pode auxiliar os profissionais na avaliação dos riscos e no estabelecimento de medidas preventivas.
Atuação da Psicologia no SUAS: percepções sobre Desenvolvimento Humano e Desenvolvimento Comunitário
Authors: Almeida Claudia De Godoi Ferreira de , Silva Rafael Bianchi
Published: November 2021

A presente pesquisa tem como objetivo analisar a percepção de psicólogos(as) com experiência de atuação em serviços de Proteção Social Básica (PSB)  do Sistema Único de Assistência Social (SUAS) acerca processos de desenvolvimento humano e comunitário, bem como suas possíveis articulações com o trabalho realizado nos serviços em que atuam. Para tanto, foram realizadas entrevistas semiestruturadas com seis psicólogas atuantes em Centros de Referência de Assistência Social (CRAS) em diferentes municípios da região norte do Paraná.  Foi possível observar que, mesmo diante de dificuldades e limitações, prevalece nos relatos das psicólogas o entendimento que de os serviços PSB são espaços potenciais para o fomento a processos de desenvolvimento humano e desenvolvimento comunitário.
Diversity in boardrooms and firm performance: The role of tenure and educational level of board members
Authors: Magnanelli Barbara Sveva , Paolucci Giulia , Pirolo Luca
Published: November 2021

Diversity on corporate boards has been studied from different perspectives in recent decades. The present study aims at investigating the impact on firm performance of two demographic diversity traits in boardrooms: tenure and educational diversity. The extant literature does not provide aligned findings on this topic, thus further research is still needed. The authors hypothesize that both tenure and educational diversity of board members have a positive effect on firm performance. To measure firm performance two dependent variables are used, applying two models for each hypothesis investigated Tobin’s Q and return on assets. The study is conducted using sample data of 187 listed firms within the European area, covering a 9-year period, from 2010 to 2018. Diversity dimensions are measured through indexes constructed on the basis of the mix among the directors in terms of educational level and tenure. The outcomes highlight a significant and positive relationship between tenure diversity on corporate boards and firm performance. In terms of the impact of educational diversity, no evidence indicating a positive effect on firm performance is found. The research carried out is unique because it considers two personal attributes of diversity calculating diversity indexes and measuring their impact on the firm’s performance. The econometric approach used has not been extensively applied in previous research. In fact, the majority of previous empirical studies have measured diversity through percentages or dummy variables, depending on the type of diversity aspect being analyzed, and then used it as the independent variable.
Analysis of stability and sensitivity of deterministic and stochastic models for the spread of the new corona virus SARS-CоV-2
Authors: Jovanovic Bojana , Ðordjevic Jasmina , Manojlovic Jelena , Suvak Nenad
Published: November 2021

Basic reproduction number for deterministic SEIPHAR model and its stochastic
counterpart for the spread of SARS-CoV-2 virus are analyzed and compared.
For deterministic version of the model, conditions for stability of the
disease-free equilibrium are derived and, in addition, conditions for
existence of bifurcation state related to endemic equilibrium are
established. For stochastic model, conditions for extinction and persistence
in mean of the disease are derived. Complete sensitivity analysis of
thresholds between the extinction and mean-persistence are performed for
both the deterministic and the stochastic version of the model. Influence of
variation in parameter values is illustrated for epidemics in Wuhan in early
2020.
Variations in the composition of essential oils of selected Artemisia species as a function of soil type
Authors: Ickovski Jovana , Jovanovic Olga , Zlatkovic Bojan , Djordjevic Milan , Stepic Katarina , Ljupkovic Radomir , Stojanovic Gordana
Published: November 2021

Five Artemisia species (seven A. alba Turra samples and twelve samples of each four remaining species: A. absinthium L., A. annua L., A. vulgaris L. and A. scoparia Waldst. & Kit.) from Serbia were studied from the aspect of essential oil chemical composition, and potential correlations between essential oil composition with soil type determined using World Reference Base for Soil Resources (WRB). A great variety in essential oil composition was observed for A. alba, A. absinthium and A. vulgaris samples, while in the case of A. annua, as well as A. scoparia, the composition of the examined essential oils was more uniform. Principal component analysis (PCA) and agglomerative hierarchical clustering (AHC) showed that there is no significant effect of soil type on the Artemisia essential oil composition while Mantel test showed that there is a correlation between samples within A. vulgaris, as well as A. scoparia and the geographical distances of the localities from which these samples were collected.
A tale of two Skimmers: complex relationships between DNA barcodes, distributions and taxonomy in European Orthetrum cancellatum and O. coerulescens
Authors: Simsonsen Thomas J. , Djernæs Marie , Nielsen Ole Fogh , Olsen Kent
Published: November 2021

We explore the genetic diversity and phylogeography of the dragonflies Orthetrum cancellatum and O. coerulescens in Europe based on mitochondrial and nuclear DNA. Orthetrum cancellatum has a clear division between a group comprising Maltese, Italian, and central and northern European populations, and a group comprising mainly populations from southwestern and southeastern Europe, as well as some northern European specimens. We propose that the two groups represent two different Glacial refugia, one in the Italian Peninsula and one in the Balkans where the species survived during the Weichsel Glaciation. Orthetrum coerulescens shows a more complex pattern, although it too can be divided into two groups. One group comprise all the specimens we have identified as O. coerulescens anceps from their phenotype as well as specimens from Spain, Montenegro, and Pakistan, and some specimens from Italiy, Poland and Bulgaria. The other group comprise all other specimens from central and northern Europe, almost all specimens from Italy and Bulgaria, and all specimens from Malta. We propose that the latter group represents an Italian Glacial refugium from which the species spread to both central Europe, Malta and southern Balkan (Bulgaria) after the end of the Weichsel Glaciation. As specimens from Spain and Bulgaria, which were identified as O. coerulescens coerulescens group with specimens identified as O. coerulescens anceps we conclude that the two subspecies mix more or less freely across the Mediterranean and question the validity of two subspecies.
Influence of mountain traffic conditions on the functional state of a bus driver
Authors:   Lviv Polytechnic National University, Postranskyy Taras , Boikiv Mykola ,   Lviv Polytechnic National University
Published: November 2021

Ensuring the transport process requires proper interaction of all parts of the system "driver - car - road - environment" and its subsystems. In this case, the driver is often a "weak" component of the system, and his actions can reduce the level of road users` safety. It should be noted that the reliability of the driver can be considered as the probability of his trouble-free and error-free operation, as well as the proper level of his regulatory mechanisms functioning. In this case, to analyze the activities and readiness of the driver for his professional activities, indicators of functional status are often used. Thus, the study of the "human factor" in the transport process is an important task to ensure the reliability of the whole transport system. Today the most of all transportation is carried out by road. The timeliness and safety of cargo delivery and passenger safety depend on the driver's actions. At the same time, the driver is influenced by a considerable number of external environmental factors during his work. One of the most important factors is the mountainous traffic conditions, which often have many changes in plan and the profile of roads. Another feature of such traffic conditions is the height above sea level, affecting the human body, particularly its functional state. Considering the above, the paper measures the heart rate variability of bus drivers moving on a route that was partly in the mountain's conditions. During the research, video recording and registration of the vehicle's geolocation were also carried out. This made it possible to establish indicators of the driver`s functional state in specific periods. After processing the obtained values, the influence of mountainous traffic conditions on the bus drivers` indicator of regulatory systems’ activity was established.
DAYA WARIS DAN HARAPAN KEMAJUAN SELEKSI KARAKTER AGRONOMI KEDELAI GENERASI F2 HASIL PERSILANGAN ANTARA YELLOW BEAN DAN TAICHUNG
Authors: Barmawi Maimun , Yushardi Andika , Sa’diyah Nyimas
Published: November 2021

Penelitian ini bertujuan untuk mengetahui nilai duga daya waris (heritabilitas) dalam arti luas dan kemajuan seleksi pada populasi F2 hasil persilangan kedelai antara Yellow Bean dan Taichung. Daya waris dan kemajuan seleksi merupakan parameter genetik dalam proses seleksi. Penelitian ini telah dilakukan di Kebun Percobaan Universitas Lampung dari November 2011 sampai dengan Februari 2012 dan dilanjutkan di Laboratorium Benih dan Pemuliaan Tanaman. Penelitian ini menggunakan rancangan percobaan tanpa ulangan. Parameter genetik yang diduga adalah heritabilitas dalam arti luas dan kemajuan seleksi. Hasil penelitian menunjukkan bahwa populasi F2 mempunyai nilai duga heritabilitas dalam arti luas yang tinggi terdapat pada karakter umur berbunga, umur panen, tinggi tanaman, jumlah polong per tanaman dan bobot biji per tanaman, sedangkan pada karakter jumlah cabang produktif dan bobot 100 butir populasi F2 mempunyai nilai duga heritabilitas dalam arti luas yang sedang. Nilai duga heritabilitas dalam arti luas yang tinggi menunjukkan bahwa suatu karakter lebih dikendalikan oleh faktor genetik daripada faktor lingkungan. Nilai duga kemajuan seleksi yang termasuk kategori rendah pada penelitian ini adalah umur berbunga, umur panen, jumlah cabang produktif, dan bobot 100 butir per tanaman, sedangkan nilai kemajuan seleksi yang tinggi terdapat pada karakter tinggi tanaman, jumlah polong per tanaman, dan bobot biji per tanaman. Nilai duga kemajuan genetik yang termasuk kategori rendah pada penelitian ini adalah umur panen, nilai kemajuan genetik yang termasuk kategori sedang terdapat pada umur berbunga dan bobot 100 butir, sedangkan nilai kemajuan genetik yang tinggi terdapat pada karakter tinggi tanaman, jumlah cabang produktif, jumlah polong per tanaman, dan bobot biji per tanaman. Tingginya nilai kemajuan genetik dalam suatu karakter mengindikasikan bahwa penampilan karakter tersebut didukung oleh faktor genetik, sehingga dapat melengkapi kemajuan seleksi.
EFIKASI HERBISIDA GLIFOSAT TERHADAP GULMA UMUM PADA PERKEBUNAN KARET (Hevea brasiliensis [Muell.] Arg) YANG SUDAH MENGHASILKAN
Authors: Oktavia Evi , Sembodo Dad . R. J , Evizal Rusdi
Published: November 2021

Penelitian ini bertujuan untuk mengetahui efektifitas herbisida Isoprofil Amina (IPA) Glifosat, untuk mempelajari perubahan komposisi jenis gulma setelah aplikasi IPA glifosat, dan untuk mengetahui pengaruh keracunan herbisida IPA glifosat pada tanaman karet menghasilkan. Penelitian ini dilaksanakan di lahan perkebunan PTPN VII Unit Usaha Way Galih dan Laboratorium Ilmu Gulma Fakultas Pertanian Universitas Lampung. Penelitian ini disusun dengan 6 perlakuan dengan 4 ulangan. Susunan perlakuan sebagai berikut yaitu isopropil amina glifosat 720 g ha -1, isopropil amina glifosat 960 g/ha, isopropil amina glifosat 1200 g ha -1 , isopropil amina glifosat 1440 g ha -1 , pengendalian mekanis dan kontrol. Homogenitas ragam diuji dengan uji Bartlet, aditivitas diuji dengan uji Tukey, dan perbedaan nilai tengah diuji dengan Uji Beda Nyata Terkecil (BNT) pada taraf 5 %. Hasil penelitian menunjukkan bahwa herbisida glifosat pada dosis 720 g ha -1 - 1440 g ha -1 mampu menekan pertumbuhan gulma total, gulma golongan rumput dan gulma dominan (Centocheca lappacea, Cyrtococcum acrescens,Ottochloa nodosa)pada tanaman karet dari 4 MSA sampai dengan 12 MSA, sedangkan gulma golongan daun lebar dan gulma dominan Sellaginella willdenowii hanya pada 4 MSA pada perkebunan karet menghasilkan, dan terdapat perubahan komposisi gulma yang tumbuh setelah aplikasi herbisida glifosat, gulma golongan daun lebar menjadi dominan.
KEMAMPUAN Trichoderma sp. DAN FILTRATNYA DALAM MENEKAN PERTUMBUHAN Sclerotium rolfsii SECARA IN VITRO
Authors: Dewi Indah Puspita , Maryono Tri , Aeny Titik Nur , Ratih Suskandini
Published: November 2021

Salah satu penyebab rendahnya produksi kedelai nasional adalah adanya serangan penyebab penyakit rebah kecambah. Pengendalian yang dapat dilakukan adalah dengan menggunakan agen antagonis. Penelitian ini bertujuan mengetahui kemampuan Trichoderma sp. dan filtratnya dalam menekan pertumbuhan Sclerotium rolfsii secara in vitro. Pengujian terdiri atas uji antagonisme dengan metode kultur ganda dan uji filtrat Trichoderma sp. terhadap pertumbuhan S. rolfsii. Percobaan disusun dalam Rancangan Acak Lengkap (RAL) dengan lima ulangan. Data yang diperoleh dianalisis dengan sidik ragam dan dilanjutkan dengan uji BNT pada taraf nyata 5%. Hasil penelitian menunjukkan bahwa Trichoderma sp. dan filtratnya mampu menekan pertumbuhan S. rolfsii secara in vitro. Isolat Trichoderma sp. yang kemampuan penghambatannya paling tinggi adalah isolat Trichoderma harzianum.
The socialization of a badminton Shuttle Time for the educative education and elementary school level in Padang Utara
Authors: Zarwan Zarwan , Hardiansyah Sefri , Zalindro Ade
Published: November 2021

The problems in this activity are many teachers who still use the methods of training in

the learning process  of physical education  of  sports and  Health  (PJOK) especially

badminton so that students do not experience improvement in the game Badminton. The purpose of this activity is to improve the teacher's ability to study badminton through shuttle time. The objective of the event is PJOK teacher in Padang Utara Sub-district with 26 people. To measure the success of this activity was given a question as much as

50 rounds before and after activities. From the question obtained initial data access is

750 (57.69) and the final data 1061 (81.62%) An increase of 23.93%.
Cytostatic treatment with irinotecan liposomal in a patient with advanced pancreatic adenocarcinoma
Authors: Będkowski Przemysław , Rogowski Wojciech
Published: November 2021

Pancreatic cancer is one of the most common malignant neoplasms with a short survival time and a low cure rate. This neoplasm progresses quickly, it is often diagnosed in the advanced stage, which means that systemic treatment regimens are not sufficiently effective. A case of 65-year-old patient with metastatic pancreatic cancer who underwent sequential chemotherapy with the use of liposomal irinotecan was presented.
EDUKASI PERILAKU CUCI TANGAN PAKAI SABUN PADA SISWA SD DI TANGERANG SELATAN
Authors: Nasir Narila Mutia , Farah Wirda , Desilfa Ragma , Khaerudin Didi , Safira Yunita , Virlian Virlian
Published: November 2021

Perilaku mencuci tangan belum menjadi budaya dalam masyarakat, Salah satu penyebab kondisi ini adalah kurangnya pengetahuan tentang hal tersebut, terutama pada anak sekolah. Kegiatan pengabdian masyarakat yang dilakukan oleh Tim Kesehatan Masyarakat UIN Syarif Hidayatullah bertujuan untuk meningatkan pengetahuan tentang CTPS sebagai salah satu upaya untuk mencegah kejadian diare. Kegiatan ini dilaksanakan kepada siswa di SDN 02 Rempoa, Tangerang Selatan dalam bentuk edukasi dan praktik cuci tangan. Hasil pre dan post-test menunjukkan adanya kenaikan rata-rata pengetahuan dari 59 menjadi 78.25 poin. Peningkatan pengetahuan ini dapat berdampak pada peningkatan praktik CTPS yang lebih baik. Selain itu para siswa diharapkan dapat menjadi agen perubahan pada lingkungannya serta menjadikan CTPS sebagai budaya yang merupakan bagian dari kehidupan seharihari. Dengan denikian secara tidak langsung juga akan menurunkan risiko penyakit menular terutama diare.---Hand washing behavior has not yet a culture in the society. This condition is caused by the lack of knowledge about the issue, especially among school children. Community service activity undertaken by the Public Health team of UIN SyarifHidayatullah aimed to increase the knowledge about WHWS as an effort to prevent the occurrence of diarrhea. This activity was carried out for elementary students at SDN 02 Rempoa, South Tangerang by performing educational session and practice of hand washing. The result of pre and post-test showed an improvement of average knowledge, from 59 to 78.25 points. The increasing of knowledge might have an impact to better WHWS practices. In addition, the students are expected to be the agents of change in their environment and make WHWS a culture in the daily life. Thus, it also will indirectly reduce the risk of infectious diseases, especially diarrhea.