bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiles of miRNA expression and IFN- serum level as biomarker for the development of Multiple Sclerosis
Authors: Abaas Baydaa ,   Department of Soil Science & Water Resources, Faculty of Agriculture, AL-Qasim Green University, Babylon 51013, Iraq.
Published: July 2024

Multiple sclerosis (MS) is associated with a wide spectrum of sensory, motor, and psychological disorders. Cytokines level and microRNA (miRNA) expression have roles in the disease's progression and the start of a damaging immune response in the central nerve system. This research study aimed to determine the role of interferon- (IFN-) and microRNA-326 (MiR-326) as prognostic factors for the development of MS disease in relation to different treatments. This case-control study included 100 participants, classified as 80 MS patients and 20 apparently healthy subjects as a control group. IFN- level was determined by an enzyme linked immunosorbent assay. The expression level of micR326 was determined by the reverse transcription polymerase chain reaction technique. The mean level of serum IFN- in MS patients (102.83 ± 15.79 ng/ml) was significantly higher than in the control group (61.25 ± 12.51 ng/ml) (p=0.001). A higher concentration of IFN- was observed in the secondary progressive form of MS disease relative to relapsing-remitting multiple sclerosis (RRMS) and in comparison, with the controls group, this IFN- cytokine level was significantly higher in treatment-naive patients. There was an increase in the mean fold change of miRNA-326 expression in patients (3.1 ±1.65) compared to the control group (1.03 ±0.23). In conclusion, secondary progressive multiple sclerosis (SPMS) has higher IFN- serum level than RRMS. MiR-326 may participate in the development of MS and its expression can be a useful biomarker for the prediction of MS.
Assessment of the impact of cytomegalovirus seropositivity on blood parameters in renal hemodialysis patients
Authors: Emad Rasha ,   Department of Clinical Pathology, Faculty of Medicine, Port Said University, Port Said, Egypt.
Published: July 2024

End-stage renal disease (ESRD) patients are considered immunocompromised, putting them at high risk for infections, including cytomegalovirus (CMV). CMV can affect hematological parameters, causing further complications in ESRD patients. This study intended to determine the seropositivity of CMV infection in hemodialysis patients and its effect on different blood parameters in ESRD patients to help decrease the overall dialysis associated morbidity and mortality. Blood samples were collected from 45 ESRD patients and 45 controls. A complete blood count was performed using an automated cell counter. CMV-specific IgM and IgG levels were measured using immunochemistry testing. The seropositivity for CMV-IgG was 42.2% in ESRD patients which was significantly higher than in control group (22.2%) (p=0.042). The seropositivity for CMV-IgM was 6.7% in ESRD patients with no difference with the control group (4.4%). The prevalence of anemia was significantly higher in CMV seropositive (77.3%) compared to CMV seronegative (47.8%) ESRD patients. Other studied blood parameters were not different between CMV seronegative and seropositive ESRD patients. In conclusion, CMV infection is a significant concern for dialysis patients and can affect hematological parameters, leading to further complications. Early detection and treatment of CMV infection and monitoring of CMV IgM and IgG levels are critical to prevent further complications and improve clinical outcomes.
Plasma type IV collagen levels as a potential biomarker for early detection of nephropathy in diabetes mellitus patients
Authors: Esawy Heba ,   Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Published: July 2024

Diabetic nephropathy represents a microvascular complication related to type 2 diabetes mellitus (T2DM) that ultimately causes end-stage renal disease. Our study aimed to evaluate the association of plasma type IV collagen with albuminuria status and to assess the clinical significance of plasma type IV collagen as a potential biomarker in the early stage of diabetic nephropathy. The study comprised 75 participants diagnosed with T2DM allocated equally (n=25) into three groups: (A) normal albuminuria levels, (B) microalbuminuria, and (C) macroalbuminuria, depending on their urine albumin-to-creatinine ratio. A comparative analysis was conducted between these groups and a control group (D, n=15). The enzyme-linked immunosorbent assay (ELISA) method was employed for measuring plasma type IV collagen levels. The results revealed that plasma type IV collagen levels were significantly higher in T2DM groups than in the control group. Moreover, diabetic patients without albuminuria had significantly higher plasma type IV collagen levels than the control group (p<0.001). Furthermore, albuminuria levels among diabetic patient groups were significantly increased as albuminuria categories increased (p<0.001). A significant positive correlation existed between plasma type IV collagen and glycated hemoglobin (HbA1c) levels in the macroalbuminuric diabetic group. Our study employed the receiver operating characteristic (ROC) curve analysis to determine plasma type IV collagen diagnostic utility in macroalbuminuria prediction. The ROC curve analysis revealed that type IV collagen can significantly determine macroalbuminuric patients at a cutoff value of 2.25 with sensitivity, specificity, positive predictive value, and negative predictive value of 68%, 100%, 100%, and 75.8%, respectively (p<0.001). In conclusion, plasma type IV collagen levels might serve as a valuable predictor of albuminuria onset in patients with T2DM.
Sunscreen activities from ethanol extract of Wodyetia Bifurcata L (family Arecaceae) fruit
Authors: Muhammad Bahi
Published: July 2024

This study aimed to determine the sunscreen activity of ethanol extract, subfraction, pure isolate and lotion of Wodyetia bifurcata fruit. In addition, the physical and organoleptic properties of the extract were determined. Sunscreen activity was measured using UV spectrophotometry, and sun protection factor (SPF) values were used. The results show that at the same concentration (extract 12%), the highest SPF value is 39.144±0.450 and the lotion is 37.039±0.368; the lowest SPF value is 36.815±0.067, and the lotion is 25.798 ± 0.392 (subfraction B). The SPF values of the pure isolate and lotion are 9.104±0.268 and 6.091±0.187, respectively. The physical properties of the extract lotion comply with the 1996 Indonesian national standards, and the most preferred formula is 2%. Gas chromatography-mass spectrometry characterization results showed that the main compound in the ethanol extract was oleic acid (18.39%). In comparison, the pure isolate obtained was β-sitosterol (4.56%), which was confirmed by proton nuclear magnetic resonance (NMR) and carbon-13 NMR data. Extract, subfraction, and pure isolate of W. bifurcata fruit have potential as sunscreen agents based on SPF values.
Potential of bovine lactoferrin as an inhibitor of cardiomyocyte apoptosis in Dexamethasone-induced hypertensive Sprague dawley rats
Authors: Hananta Linawati
Published: July 2024

Elevated blood pressure, also known as hypertension, significantly increases the risk of developing heart disease. It can damage heart muscle cells and trigger apoptosis (cell death). Antioxidants like lactoferrin can help protect the heart from damage by reducing the generation of reactive oxygen species (ROS), harmful molecules that can damage cells. This study aims to evaluate the efficacy of lactoferrin in alleviating apoptosis in cardiomyocytes by assessing caspase-3 levels. This study randomly assigned 32 rats into 6 groups: control, dexamethasone, positive control, and 3 lactoferrin groups (100, 300, and 500 mg/kg BW/day). All groups except control received dexamethasone for 14 days. On day 14, rats were euthanized, and heart muscle tissue was collected. Caspase-3 levels were measured and analyzed using One-Way ANOVA. The average caspase-3 enzyme levels in the lactoferrin-treated groups with 100, 300, and 500 mg/kg BW/day were 2,605.0, 2,720.9, and 2,518.8 ng/mL, respectively.
Effects of zinc and probiotic co supplementation on lipid profile, waist circumstance, and body fat percentage in obesity women
Authors: Ratna Noer Etika
Published: July 2024

Obesity is a state of excessive fat accumulation due to a prolonged imbalance between energy intake and expenditure. Zinc deficiency is crucial in the etiology of obesity/overweight, and is a consequence of excessive body weight as well. Hypozincemia worsens metabolic, immune, and oxidative status in obesity. Increasing zinc intake through diet or supplementation may be a viable strategy to reduce obesity-related disorders or conditions. Probiotic strain Lactobacillus casei Shirota is a lactic acid bacterium that has benefits for boosting the immune system, as an antioxidant, and can reduce cholesterol levels. This study analyzed the effect of zinc supplementation, Lactobacillus casei (LCS) and their co-supplementation on lipid profile consisting of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG), waist circumstance and body fat percentage in obese women. Eighty-four participants were randomized to four groups (zinc (30 mg/day), LCS (6,5x109 CFU/day), "zinc and LCS”, and placebo) for 30 days. Lipid profiles, anthropometric indicators, and dietary intake were determined pre and post-intervention. In the zinc group, LCS group, and “zinc and LCS” group showed significant differences between pre and post-intervention in serum TC, LDL, HDL, and TG (p < 0.05). On anthropometric indicators, all groups showed significant differences between pre and post-intervention on waist circumstance and body fat percentage (p < 0.05). The beneficial effects of "zinc and LCS” co-supplementation were reported for the changes of some lipid profiles (TC, LDL, HDL, TG), BMI, weight, waist circumstance, and body fat percentage.
Detection of pulmonary tuberculosis and rifampicin resistant tuberculosis from sputum samples in a tertiary care hospital, Delhi & NCR, India
Authors: Payal Nikhil
Published: July 2024

This study examines pulmonary TB diagnosis and Rifampicin resistance in sputum samples from a Delhi tertiary hospital. Findings indicate a 3.08% TB prevalence, significant gender differences, and morning specimens' diagnostic superiority. Mycobacterium tuberculosis (TB) ranks second only to the Human Immunodeficiency Virus (HIV) in terms of infectious disease-related deaths, and it also plays a significant role in the development of antibiotic resistance worldwide [1]. The Mycobacterium tuberculosis complex is responsible for transmitting it, making it one of the oldest diseases known to affect humans and a major cause of death on a global scale [2]. Mycobacterium tuberculosis is a thin, aerobic bacterium that measures 0.5 x 3 m, is rod-shaped, and is non-spore-forming in nature. Acid-fast microorganisms are known as mycobacteria.
Effect of anticancer electromagnetic spectrums on the cancer cell line growths
Authors: H Al-Ghamdi Fuad
Published: July 2024

Electromagnetic frequencies (EMF) that are generated from different electronic devices can interact with biological systems including humans. Several theories described the effects of EMF on the growth of in vitro cancer cell lines and biological systems, which revealed that EMF could inhibit cancer cell growth or decrease viability depending on the field strength and frequency. Accordingly, in this study, we are targeting to assess the effect of the anticancer-extracted electromagnetic spectrums on the growth of two types of cell lines which are the breast cancer cell line MCF-7 and human embryonic kidney HEK293 as a control cell line. Drugs digitalized electromagnetic spectrums of a mixture of anticancer medications were generated using a DigiConPro® VITATEC device emitted using the supplied antenna and applied to a 96-well culture plate containing MCF-7 and HEK293. The cell viability was performed by MTT assay after three days. The post-exposure effect of anticancers' electromagnetic spectrums was determined on the cancer cell line. Anticancers’ electromagnetic spectrums were seen to cause a statistically significant (p<0.05) decrease in the growth rate relative to the control after three days of exposure to the electromagnetic spectrums. Three doses of anticancers’ electromagnetic spectrums were applied as a dose per day, and each dose was running for 5 hours which induced a reduction in MCF-7 growth compared to the control group, while the HEK293 showed no statistically significant decrease in the growth rate. As a conclusion, electromagnetic spectrums of the anticancer medications may have the same effect as the chemical compound.
Role of Persuasion in Online Purchases: A Conceptual Framework
Authors: V Ashok Mammen , Bharathi T.
Published: July 2024

The trend towards online purchases continues to grow globally with significant increases in both the number of consumers and the volume of transactions. Indian e-commerce market is likely to show positive growth trend in the coming years. The study focuses on the role of persuasion and the factors related to attitude formation that leads to purchase intention among the population. The literature study covers online purchases, factors, time period from 1967 to present year. The identified variables for the study are marketer generated content, user generated content, social influence, trust, persuasion, attitude and purchase intention. The conceptual framework is proposed and is designed from the above select variables to understand the role of persuasion and its influence on attitude and purchase intention.
Effect of Dining Service Quality and Social Media Marketing on Intention to Revisit with Customer Satisfaction as an Intervening Variable at in out Cafe Medan
Authors: Puspita Debrina , Ginting Paham , Sembiring Beby Karina Fawzeea
Published: July 2024

This research aims to analyze effect of dining service quality and social media marketing on intention to revisit with customer satisfaction as an intervening variable at In Out Cafe Medan. The research used in this research is associative research. Population in this research is consumers of in out Cafe Medan which was conducted from September 2023 to January 2024 with an unknown number. In this research, the sampling method used was non-probability sampling. The minimum sample size is 5-10 observations for each parameter being estimated, suggesting that the minimum sample size be 5-10 times the indicator variable. So the number of indicators is 23 multiplied by 5 equals 115. So through calculations based on this formula, the sample size for this research is 115 people. The data analysis model used in this research uses path analysis. Based on the research results show that dining service quality has a positive and significant effect on customer satisfaction at In out Cafe Medan. Social media marketing has a positive and insignificant effect on customer satisfaction at In out Cafe Medan. Dining service quality has a positive and significant effect on intention to revisit at In out Cafe Medan. Social media marketing has a positive and insignificant effect on intention to revisit at In out Cafe Medan. Customer satisfaction has a positive and significant effect on intention to revisit at In out Cafe Medan. Dining service quality has a significant effect on intention to revisit through customer satisfaction at In out Cafe Medan. Social media marketing does not have a significant effect on intention to revisit through customer satisfaction at In out Cafe Medan.
Dynamics of Political Communication and Personal Branding Joko Widodo as a President Indonesia via Instagram @Jokowi
Authors: Claudia Vrista , Sutjipto Vera Wijayanti , Putri Maulina Larasati
Published: July 2024

This research examines the dynamics of political communication and personal branding of Joko Widodo or who is familiarly called Jokowi Dodo, with a focus on his interactions with the public, the impact of his political messages, and maintaining his personal image. Through qualitative research methods and a case study approach, data was collected mainly from Jokowi's official Instagram account (@jokowi) and supplemented with relevant literature. Analysis shows that Jokowi uses various communication strategies, including short speeches and political messages on social media platforms such as Instagram, which are accompanied by visual documentation of his activities. His political messages, which emphasize infrastructure development and pandemic management, influence public perception, although challenges remain, especially regarding policy implementation. Jokowi's personal branding, characterized by simplicity, strong leadership and consistency, was received positively by the public, contributing to his popularity. Additionally, media coverage plays an important role in shaping public opinion, despite criticism and controversy surrounding Jokowi's administration. Overall, this research contributes to a deeper understanding of the complexities of political communication and personal branding, and offers insights into the dynamics of leadership and public perception.
Indian Tourism - Emerging Opportunities, Challenges and Future Trends
Authors: Gurunathan Anoop , Lakshmi K.S.
Published: July 2024

Travel and tour have always been part and parcel of everyone’s life. The need for recuperation from the tensions of modern life forced people to take up tours for leisure and medical purposes. This increase in general awareness among people for travelling has created a favourable condition for the growth of the tourism sector in India. India is divinely blessed with nature, diverse geographical attractions, and destinations. The tourism sector has always been a bright spot in India, due to its growth potential and its impact on the economy. But, as every sector has its strengths, so have its weaknesses and threats. Therefore, this study takes an in-depth analysis based on secondary data about the strengths, weaknesses, threats, opportunities, and future trends of Indian Tourism. The study also tries to provide suggestions that can be considered by authorities, stakeholders, and tourism departments for the improvement of the sector.
Pembuatan Spot Foto Kerang sebagai Upaya Optimalisasi Potensi Desa Wisata
Authors: Fadhil Achmad , Kurniati Ruri Fadhilah , Cahyanti Qori' Nur , Saniya Shabrina Vira , Rochmah Latifatur , Izzah Lutfiyatul , Putri Adelia Trisna , Ilmi Laila Ulul , Amelia Tarisa , Lailia Afdholul Nisfu , Maulidyah Aminah Nurhidayati
Published: July 2024

Pengembangan wisata desa wajib dilakukan oleh setiap warga karena memiliki potensi dalam kemajuan desa. Pembangunan wisata melalui renovasi dan pengoptimalan spot foto Kampung Bahari yang dilakukan oleh sivitas akademika UNUSIDA tahun 2023 juga pernah direalisasikan pada tahun 2019. Pembuatan spot foto di tanggul pelabuhan nelayan Desa Gisik Cemandi dilakukan dengan menggunakan limbah kulit kerrang. Pada kegiatan ini, promosi wisata dilakukan dengan bantuan dan dukungan remaja desa, yaitu KARTAR dan IPNU IPPNU Desa Gisik Cemandi, melalui media sosial. Promosi ini bertujuan untuk mengembangkan eksplorasi wisata spot foto Kampung Bahari oleh pengunjung dari luar wilayah Desa Gisik Cemandi.
The development of village tourism must be carried out by every resident because it has the potential to improve the village. Tourism development through renovation and optimization of the Kampung Bahari photo spot carried out by the UNUSIDA academic community in 2023 was also realized in 2019. The creation of a photo spot on the embankment of the fishing port of Gisik Cemandi Village was carried out using shell waste. In this activity, tourism promotion was carried out with the help and support of village youth, namely KARTAR and IPNU IPPNU Gisik Cemandi Village, through social media. This promotion aims to develop tourist exploration of the Kampung Bahari photo spot by visitors from outside the Gisik Cemandi Village area.
Gestión administrativa y su impacto en los clientes en el sistema de facturación electrónica de la empresa Ecofiner del cantón Quevedo, año 2023
Authors: Granados Rivas Yanila Esther , Chu Zheng Kaven Alberto , Fernández Romero Tani Irlanda , Caiza Villareal Henry Patricio
Published: July 2024

La presente investigación tiene por finalidad analizar la gestión administrativa y su incidencia en la calidad del servicio de los usuarios en el sistema de facturación electrónica de la empresa ECOFINER, en el cantón Quevedo, con base a las disposiciones legales vigentes del Ecuador. El Servicio de Rentas Internas (SRI) es la máxima autoridad de recaudación del país y en los últimos años se han venido automatizando procesos en distintas áreas buscando la generación de servicios ágiles y oportunos que generan valor diferenciador a los usuarios, para lograr un punto de rentabilidad, eficiencia a corto y mediano plazo para el país. El objetivo del estudio es Analizar la incidencia de la gestión administrativa en la calidad del servicio de facturación electrónica en los clientes de la empresa ECOFINER. La investigación fue de campo y descriptiva, aplicados métodos inductivos, deductivos, analíticos, lo que posibilitó obtener información relevante como sustento para el desarrollo del proyecto de investigación, también instrumentos como la entrevista, la encuesta, análisis FODA y grupos de discusión, que expusieron un análisis general de la propuesta de investigación. Los resultados demuestran que la mayoría de los clientes están satisfechos con el servicio, sin embargo, persiste un porcentaje que debe ser identificado y atendido, la administración es rígida y la calidad del servicio es adecuada, pero debe seguir mejorando. En conclusión, el 74% de satisfacción del cliente denota que es muy bueno. La calidad está relacionada a la gestión administrativa y su accionar.
RFID Untuk Sistem Keamanan dan Pelacakan: Tinjauan Literatur
Authors: Zakaria Diky , Tri Seda Mulya  , Maharani Aisyah Aira Putri , Steven Michael
Published: July 2024

Pada era perkembangan teknologi yang semakin pesat, pelacakan dan keamanan menjadi aspek yang sangat penting dalam berbagai bidang industri. Hal ini merupakan sebuah respons terhadap tantangan global yang semakin kompleks. Salah satu teknologi yang dapat menjawab tantangan ini adalah teknologi RFID. Dengan RFID, pengelola industri dapat melakukan pelacakan inventaris yang akurat secara real-time, melakukan pemantauan yang jauh lebih akurat terhadap aliran barang, serta mengidentifikasi potensi kerugian akibat hilangnya barang atau kerusakan dalam rantai pasokan. Artikel ini mengulas berbagai artikel dari database scienceDirect yang berhubungan dengan penggunaan RFID pada sistem keamanan dan pelacakan dengan pertanyaan penelitian: bidang yang menggunakan RFID, reader yang digunakan, tag yang digunakan, dampak, dan komunikasi data. Metode yang digunakan pada penulisan ini adalah Systematic Literature Review (SLR). Hasil artikel review ini dapat memberi gambaran bahwa menurut mayoritas artikel, bidang yang paling banyak memanfaatkan RFID untuk sistem keamanan dan pelacakan adalah bidang manufaktur yang menggunakan tag dan reader RFID pasif melalui sistem komunikasi nirkabel dengan memasang tag pada objek yang digunakan dan menempatkan reader pada akses-akses tertentu. Penggunaan RFID ini juga memiliki berbagai dampak yang positif menurut mayoritas artikel seperti dapat mempersingkat waktu operasional, melacak objek kecil, meminimalisir kesalahan pelacakan, serta memperkecil biaya yang dibutuhkan.
Analisis Perbaikan Drop Tegangan dengan Metode Pecah Beban pada Penyulang GNAP PT. PLN (Persero) ULP Plered
Authors: Nurjaman Dede Furqon , Hakim Achmad Rifan  , Taryana Een , Hidayat Wahyu
Published: July 2024

Kebutuhan energi listrik terus meningkat setiap tahun seiring dengan teknologi yang semakin modern dan ketergantungan masyarakat terkait pemenuhan kebutuhan listrik. Ketergantungan masyarakat terkait listrik, mendorong peningkatan mutu listrik oleh PLN salah satunya adalah perbaikan kualitas tegangan. Pada PT. PLN (Persero) Unit Layanan Pelanggan (ULP) Plered terdapat penyulang dengan tegangan ujung masih di bawah standar. Pada penelitian ini, dibuat analisis sistem terkait perbaikan drop tegangan pada penyulang GNAP dengan bantuan simulasi ETAP. Perbaikan drop tegangan dilakukan dengan metode pecah beban penyulang yaitu memindahkan sebagian beban ke penyulang lain.  Hasil yang diperoleh, drop tegangan pada penyulang GNAP mengalami penurunan yang awalnya 1.19 kV menjadi 0.84 kV pada beban siang dan 1.24 kV menjadi  0.90 kV pada beban malam. Drop tegangan dalam persen juga mengalami penurunan yang awalnya 5.95% menjadi 4.18% pada beban siang dan 6.20% menjadi 4.51% pada beban malam.
Desafios enfrentados por agricultoras do assentamento paulo fonteles para ingresso, permanência e êxito no ensino superior
Authors: Assunção Aline Ferreira , Silva Eldeenaldo Ferreira da , Assunção Alessandra Ferreira , Sales Reinaldo Eduardo da Silva
Published: July 2024

O presente estudo analisa as dificuldades enfrentadas por mulheres residentes em áreas rurais, com especial enfoque no Assentamento Paulo Fonteles, no estado do Pará, ao buscar concluir cursos de ensino superior. Do ponto de vista metodológico, foi utilizado como instrumento de coleta de dados um roteiro de entrevistas orais transcritas e escolhidas trechos para acrescentar na pesquisa, são três mulheres que estavam em seus percursos acadêmicos escolhidos para as analises, cujo foco era saber como elas superaram os obstáculos no ensino superior, associando suas atividades acadêmicas com a agricultura e os afazeres domésticos, as perguntas foram abertas e deixando fluir os relatos das entrevistadas. Os resultados demonstraram que a inserção dessas mulheres nos cursos de graduação produziu impactos significativos em suas vidas, confrontando-as com conflitos familiares e culturais, que, frequentemente resultou na interrupção de suas trajetórias educacionais. O estudo apontou também para a importância de se compreender tais desafios para promoção de alternativas que viabilizem a permanência e êxito nos cursos de graduação por parte dessas mulheres do campo.
Aplicação do instrumento ISARIC em pacientes pré e pós Covid-19 internados em enfermaria e unidade de terapia intensiva: comparação entre as variáveis e grupos
Authors: Silva Guilherme Augusto Moreira , Oliveira Luís Vicente Franco de , Oliveira Miriã Cândida , Alves Larissa Rodrigues , Stirbulov Roberto , Oliveira Bruna Almeida Pires Franco de , Pereira Juliano , Costa Matheus André Ribeiro da , Oliveira Deise Aparecida de Almeida Pires , Oliveira Rodrigo Franco de
Published: July 2024

Introdução: O Consórcio Internacional de Infecções Respiratórias Agudas Graves e Emergentes (ISARIC) é uma plataforma global endossada pela Organização Mundial da Saúde (OMS), que permite a caracterização de indivíduos hospitalizados por COVID-19. A infecção pelo SARS-CoV-2 leva a diferentes tipos de complicações sistêmicas e graus de comprometimento funcional em indivíduos que desenvolvem a forma grave da doença. Objetivo: Descrever as características epidemiológicas e clínicas dos pacientes antes e após a internação por COVID-19 até 2 semanas após a alta hospitalar. Métodos: Estudo observacional, transversal, realizado com 98 pacientes COVID-positivos que apresentavam sinais e sintomas pós-COVID, internados em enfermaria e unidade de terapia intensiva em hospitais terciários da cidade de Anápolis e região, durante o ano 2021. O protocolo ISARIC foi utilizado para avaliar os participantes antes e depois da infecção por COVID-19 em relação domínios de qualidade de vida e funcionalidade. Resultados: As comorbidades mais frequentemente encontradas foram hipertensão, diabetes e obesidade. O tempo de internação médio foi de 13,69 dias. Observou-se uma taxa de utilização de ventilação invasiva maior no grupo hospitalizado em UTI. Na comparação intragrupo (pré vs pós-COVID), houve piora em diversos domínios relacionados à qualidade de vida e funcionalidade dos indivíduos (p<0,001). Conclusão: As características epidemiológicas e clínicas na amostra estudada demostrou-se similar ao encontrado na literatura. A infecção por COVID-19 impactou um declínio significativo na qualidade de vida e funcionalidade dos pacientes que foram hospitalizados com COVID-19.
Calculation of areas of polygons using trapezoids
Authors: Barboza Marcelo Oliveira , Silva Cleomacio Miguel da
Published: July 2024

The area of a polygon is the region occupied by a polygon. Polygons can be regular and irregular. The basic polygons used in geometry are triangle, square, rectangle, pentagon, hexagon, etc. All of these polygons have their own area. For regular polygons, it is easy to find their area, as the dimensions are defined and known to us. For example, the area of a square can be easily determined if we know the length of one of its sides, since all its sides are equal. For the computation of area, there are pre-defined formulas for squares, rectangles, circle, triangles, trapeziums etc. However, for an irregular polygon, the area is calculated by viewing it as a combination of 2 or more regular polygons. The area of any given polygon whether it a triangle, square, quadrilateral, rectangle, parallelogram or rhombus, hexagon or pentagon, is defined as the region occupied by it in a two-dimensional plane. The areas or formulas for areas of different types of polygon depends on their shapes. Suppose, to find the area of the triangle, we have to know the length of its base and height. For finding the area of a polygon which is not regular or its formula is not defined, we split the figure into triangles, squares, trapezium etc. The purpose is to visualize the given geometry as a combination of geometries for which we know how to calculate the area. We then calculate the area for each of the part and then add them up to obtain the area of the polygon. Therefore, and within this context, the objective of the present work was to develop a new methodology to calculate the area of any polygon using trapezoids. The results obtained showed that the developed methodology can be efficiently used to calculate the area of regular and irregular polygons.
Implicações administrativas e operacionais da concepção de observatórios de turismo (OTUR): estudo de caso sobre o observatório do turismo da Serra Gaúcha (OTUR SG)
Authors: Bregolin Michel , Pereira Patricia Carvalheiro , Bortolotto João Pedro Zanella , Alves Thalia Ferreira , Rocha José Vitor Fontoura Brandolt da , Mattos Lenita Luzia de , Moeller Nathalia Luana Ritter , Frizzo Julia
Published: July 2024

Observatórios de Turismo (OTURs) são um recurso institucional importante dos destinos turísticos pois mediam a percepção da realidade dos atores envolvidos com a construção de uma visão coletiva desses locais. Ao incentivarem uma perspectiva menos autocentrada das partes interessadas os observatórios contribuem para uma maior racionalidade das governanças turísticas via a implementação de processos de pesquisa-ação que favorecem a constituição de inteligências coletivas. Nesse quadro, tendo como referência a literatura sobre o assunto, este artigo discute implicações administrativas e operacionais sobre OTURs ocasionadas por decisões tomadas durante o processo de concepção desses observatórios. Para isso, descreve e analisa o caso do Observatório do Turismo da Serra Gaúcha (OTUR SG) que considerou essas implicações e buscou alternativas para fortalecer sua perenidade. Entre os principais resultados obtidos pelo estudo podem ser destacados: a necessidade de atentar para aspectos relacionados com os dados, envolvendo sua escolha, tratamento e formas de divulgação dos indicadores e análises; a importância da definição da abrangência espacial do Observatório; assim como da escolha cuidadosa de meios de incentivo à participação e à sua apropriação pelos usuários.
Responsabilidade socioambiental na escola médica
Authors: Oliveira Vanessa Cristina de Castro Aragão , Araripe Ana Letícia de Aragão Oliveira , Nascimento Manuella Rita Celestino do , Machado Norma Cristina de Aragão Oliveira Pinheiro , Grande Julia Celestino
Published: July 2024

Este é um relato de experiência, cujo objetivo é descrever a vivência dos autores em uma atividade de responsabilidade socioambiental realizada na orla do Estado do Piauí/Brasil, integrada à Área de Proteção Ambiental Delta do Parnaíba, sensibilizando estudantes, professores e colaboradores de uma instituição privada de ensino superior, sobre os diversos impactos que a poluição direta ou indireta causa nos oceanos, praias (principalmente na desova de tartarugas) e no meio ambiente em geral, bem como a necessidade de preservá-los. O resultado mostrou que, para que este cidadão desempenhe um papel consciente na sociedade, são necessários educação e conscientização ambiental, bem como acesso a informações ambientalmente qualificadas. Dessa forma, a atividade despertou nos participantes o senso de responsabilidade implicado pelo descarte de resíduos poluentes prejudiciais à fauna e flora marinhas, tornando-os mais sensíveis e receptivos à multiplicação de informações e atitudes corretas não apenas nas áreas de proteção ambiental, mas no meio em geral.
(Com)vivências de uma coordenadora pedagógica em uma grande cidade do interior de São Paulo
Authors: Hautz-Dias Paula Rezende , Assolini Filomena Elaine Paiva
Published: July 2024

Este Relato de Experiência tem o objetivo de trazer um recorte da rotina profissional de uma coordenadora pedagógica em uma grande rede municipal do interior do estado de São Paulo, pautando-se na Análise de Discurso (AD) de Matriz Francesa Pecheutiana, na observância de quanto a pouca ou nenhuma formação em gestão escolar, de diretoras e suas vices (e sua evidente rotatividade), pode corroborar para o insucesso escolar. O local de análise foi uma grande escola pública municipal e os envolvidos foram o trio gestor – corpo docente, os discentes e a comunidade escolar. Os resultados observados abrangem a necessidade imediata da oferta de formação para diretores, vices e a urgência de determinar a entrada, nesses cargos, apenas por concurso público, além da valorização do profissional coordenador pedagógico. Este relato implica diretamente conclusões para se repensar o modo como gerimos nossas escolas brasileiras e formamos cidadãos críticos e capazes de transformar para melhor o nosso país. Este trabalho, portanto, vem a contribuir para o reconhecimento do coordenador pedagógico e como esse profissional tem, em suas funções, habilidades tão importantes, a ponto de fazer intervenções em muitas situações consideradas um entrave ao bom clima escolar e, também, no que diz respeito às relações da própria escola com seu entorno, ou seja, com a comunidade escolar.
Identification & Importance of Antimicrobial Susceptibility Of NonFermenting Gram-Negative Bacilli Among Various Clinical Specimens In A Tertiary Care Hospital
Authors: Bhatia Dr. Josita , Prajapati Dr. Bhavin , Shaikh Dr. N. M. , Chauhan Dr. Bimal , Odedra Dr. Hetal , Pethani Dr. Jayshri
Published: July 2024

Introduction:Non-fermenting gram-negative bacilli (NFGNB)have emerged as important healthcareassociated pathogens. NFGNBs are innately resistant to many antibiotics and are known to acquire resistance by producing extended-spectrum beta-lactamase. This makes treatment of infections caused by these pathogens both difficult and expensive. Therefore, this study is undertaken with the aim of identification of NFGNB and their antimicrobial susceptibility pattern in our hospital. Material and Method: A total of 3233 specimens were received in the bacteriology section of the microbiology department from September 2022 to May 2023. Clinical specimens were processed for culture according to standard operating procedures. Identification and antibiotic sensitivity testing were performed by an automated: VITEK-2 compact system.Result: A total of 486 (15.03%) NFGNB were isolated from 3233 clinical specimens. Out of 486 isolates, Acinetobacter baumannii complex was the most common non-fermenter, accounting for 238 (48.97%) isolates, followed by Pseudomonas aeruginosa 229 (47.12%). Other significant NFGNBs isolated were: Stenotrophomonas maltophilia 4 (0.82%), Myroides spp. 4 (0.82%) etc. Vitek 2 detected carbapenem resistance in 226 (95%) of A. baumannii complex and 135 (59%) of P. aeruginosa isolates. Conclusion: A. baumannii complex and P. aeruginosa were the most common NFGNB isolated from wound swabs, bronchoalveolar lavage (BAL), blood, sputum, tissue, and pus. They were found to be most resistant to quinolones, carbapenems, and aminoglycosides.
Keywords:– Non-Fermenting Gram-Negative Bacilli, Antimicrobial susceptibility, VITEK -2
Severe haemolytic disease of newborn with possibility of blocked D phenomenon:A Case Report
Authors: Thakkar Garima H. , Bhatnagar Nidhi M. , Shah Sangita D. , Shah Mamta C
Published: July 2024

Anti-D is the most common antibody causing severe hemolytic disease of foetus and newborn (HDFN).The mothers who have very high titres of anti-D,antibodies can coat and block D antigens on red blood cells (RBCs) of the newborn.This blocking phenomenon prevents the agglutination of RBCs with IgM type of anti-D antisera.This results in false negative results.Here, we report the case of 1 day old baby born to a multiparous female with Rh Negative blood group suffering from severe HDFN.Mother and baby’s samples were sent to our blood centre for the advanced immunohaematological analysis.On detailed immunohaematological work up, possibility of blocked D phenomenon was considered.
key-words: Haemolytic disease of foetus and new born, Blocked D Phenomenon,
Maternal anti-D antibody.
Pattern of Refractive Error among Amblyopic Children at tertiary referral hospital of Ahmedabad, Gujarat.
Authors: Prajapati Dr. Vaishali , Vyas Dr. Surili , Garasia Dr. Sneha , Thakkar Dr. Dharti , Shah Dr. Kushang , Singhal Dr. Deepika
Published: July 2024

Introduction: Amblyopia is one of the common causes of preventable uniocular or binocular vision loss in children. Timely diagnosis and management of amblyopia is crucial. If corrective measures are not taken in time it becomes permanent. Aim: To study the various types of refractive errors in amblyopic children aged 5-18 years in tertiary eye hospital. Materials and Methods: Retrospective cross –sectional study was carried out in the tertiary eye care hospital. All the children attending the ophthalmology OPD during January2021 to January 2023 were enrolled. All underwent detailed ophthalmic evaluation. After post mydriatic test, children with difference of two lines or
more in visual acuity on Snellen chart were taken and detailed ophthalmic evaluation done. Results: The prevalence of amblyopia was 6.2% (n=48) with male dominant of 62.5% (n=30), while female was 37.5% (n=18). In types of Amblyopia, most common was simple Hypermetropic of 42% (n=20) followed by simple myopic and hypertropic Astigmatism 19% (n=9) in each. The Anisometropia Amblyopia was in 12% (n=6), while myopic astigmatism in 8%(n=4). The 69%(n=33) was binocular while 31% (n=15) was uniocular amblyopia. Conclusion: The Refractive errors are treatable and preventable cause of amblyopia. Timely diagnosis and proper treatments like spectacles, contact
lenses, patching and active vision exercises, we can treat Amblyopia and prevent the psychosocial, economical loss in adult life.
Keywords: Myopia, Hypermetropia, Anisometropia, Astigmatism
Comparison of Dexmedetomedine with Fentanyl for Prevention of
Etomidate Induced Myoclonus
Authors: Thacker Dr. Pinak R. , Parmar Dr. Siddharthkumar B. , Bhatia Dr. Prince
Published: July 2024

Background & Aims: Etomidate has a stable cardiac profile as an induction agent. But, reportedincidence of etomidate induced myoclonus is 50% to 80%. This study was conducted to compare theeffect of dexmedetomidine with fentanyl for reduction of etomidate induced myoclonus. Materialsand Method: This study was conducted in 60 ASA grade I,II,III patients in the age group of 18-55years undergoing elective surgeries under general anaesthesia. Patients were randomized and dividedinto 2 groups of 30 patients each. Group 1 received Inj. dexmedetomidine 0.5 mcg /kg iv and Group 2received Inj. fentanyl 1 mcg /kg iv as a premedication slowly over 5 mins. After that, they wereadministered Inj. etomidate 0.3 mg/kg and were observed for myoclonus for 2 minutes. Severity ofetomidate induced myoclonus was assessed using four point intensity scoring. Safety of study drugswas compared using mean HR, mean BP and adverse events observed. Results: Myoclonus wasobserved in 36.67% patients after inj. dexmedetomidine 0.5 mcg /kg and in 50% patients after inj.
fentanyl 1 mcg /kg (P value = 0.046). Incidence of myoclonus with grade 1,2 and 3 was 26.66%, 10%and 0% respectively in group 1 and 33.33%, 13.33% and 3.33% in group 2 respectively. Conclusion:Incidence of etomidate induced myoclonus was significantly decreased in patients pre-treated withdexmedetomidine in comparison with fentanyl. In terms of severity grading, difference betweenthese two drugs was insignificant.
Keywords: Myoclonus, Etomidate, Dexmedetomidine, Fentanyl.
Effectiveness of two different doses of intravenous labetalol on attenuation of hemodynamic responses to laryngoscopy and intubation in controlled hypertensive patients undergoing major abdominal surgeries under general anaesthesia - A randomized trial
Authors: Nagar Dr. Richa , Ahmed Dr. Fareed , Nanda Dr. Samridhi , Morwal Dr. Sanjay Kumar
Published: July 2024

Introduction: Laryngoscopy and endotracheal intubation provoke physiological responses, violate thepatient’s protective airway reflexes and predictably lead to hemodynamic changes. The present studywas aimed to compare the effectiveness of two doses of intravenous labetalol in attenuatinghemodynamic responses associated with laryngoscopy and endotracheal intubation by observingchanges in the patient’s heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP)and mean arterial pressure (MAP). Materials and Method: This was a hospital-based randomizeddouble-blinded interventional study which included 72 patients with controlled hypertension, agedbetween 20 to 60 years, undergoing elective open abdominal surgery, requiring general anaesthesiaand orotracheal intubation. Patients were assigned into two groups of 36 each: Group A: Labetalol
0.15 mg/kg and Group B: Labetalol 0.3 mg/kg diluted with 0.9% normal saline to make up to 10 mLand was given intravenously 5 min before intubation. HR, SBP, DBP, MAP and oxygen saturation(SpO2) were recorded before induction, at the time of intubation and 1, 3, 5, and 10 min afterintubation. Results: HR, SBP, DBP and MABP were significantly attenuated in. Group B at intubation, 1 min, 3 min, 5 min, and 10 minutes after intubation. Conclusion: Labetalol in the dose of0.3 mg/kg provides better hemodynamic stability than labetalol in the dose of 0.15 mg/kg onsympathetic stimulation due to direct laryngoscopy and endotracheal intubation.
Keywords: Intravenous labetalol, hemodynamic changes, direct laryngoscopy, endotracheal intubation, controlled hypertensive patients, open abdominal surgery.
Study of Clinical Profile, Management and Outcome of Patients Presented with Seizures in Emergency Medicine Department
Authors: Virani Dr. Devanshi , Sangani Dr. Shruti V. , Patel Dr. Chirag J. , Patel Dr. Vishakhaben G. , Saha Dr. Joy , Kalsariya Dr. Rahul
Published: July 2024

Background: Seizures are sudden, uncontrolled electrical disturbances in the brain that causes widerange of symptoms. Predominant causes are CNS infection, trauma, space occupying lesion, cerebrovascular accidentsetc. The goal of the emergency clinician is to differentiate seizures from mimics andidentify reversible causes.Management focuses on identifying reversible causes such as hypoxia,
hypoglycemia and initiating pharmacological treatment. Aim: The aim is to study different variablesrelated to clinical profile, management and outcome of the patients presenting with seizures inEmergency Department (ED).Material & Methods: We conducted a prospective observational studyon 200 patients who presented with seizures in the emergency medicine department according toinclusion and exclusion criteria from September 2020-October 2021. In all patients of our study,
primary and secondary surveys along with immediate resuscitation were done. A brief history, clinical
examination and all necessary hematological and radiological investigations were done. Patients weretreated accordingly and followed-up until discharge or death.Results: Out of 200, 73% patients weremales and 27% were females. Mean age of study population was 49.3 years. Idiopathic(26%) was theleading cause followed by alcohol withdrawal seizure(20%) and cardio-vascular accident (13%) withgeneralized tonic clonic seizures (GTCS) being the commonest type (67%). Majority of patients(95%) were treated with anti-epileptic drugs (AEDs).Conclusion:Along with immediate primaryresuscitation, early identification, prevention of recurrence and treating the cause forms the basis ofmanagement of seizures in emergency department.
Key Words: Seizure, Management, Idiopathic, Emergency department
A Study On Insight Into Cessation Attempts Among Current Smokeless Tobacco Users In An Urban Slum Of Ahmedabad
Authors: Shenoy Vidhya R , Bhagyalaxmi A. , Patel Parimal , Verma Abhishek , Lalwani Nandhini Kamlesh , Madhu Jay Sanjay
Published: July 2024

Introduction:According to GATS-2 report, one out of every five persons in Gujarat uses smokelesstobacco (SLT).Tobacco causes addiction & dependence over a period of time.Tobacco cessation is anintegral part of the National Tobacco Control Programme.Objective:To estimate the proportion ofprevious quit attempts and its determinants among current SLT users of an urban slum inAhmedabad.Methods:A community-based, cross-sectional study using consecutive sampling wasconducted between June 2023 - August 2023 among 250 current SLT users in an urban slum ofAhmedabad( Ward number 15). A pre-tested, semi-structured questionnaire adapted from GATS-2(Global Adult Tobacco Survey-2) Tobacco Questions for Surveys was administered among theparticipants for eliciting sociodemographic characteristics, SLT consumption pattern and quittingattempts. Results:In this study, 68.8% of the participants had at least one past quit attempt out ofwhich 94.7% tried self- control methods. The most common reason for not being able to quit wasperceived as addiction (70.9%). A larger part of SLT users (89%) had noticed warning labels intobacco packets and 18.3% of them reported that they thought of quitting seeing that warning. Threefourth of the participants were advised by at least one person to not consume tobacco products & in60% of the cases, it was the spouse.Conclusions and recommendations:The results suggest that
there is an obvious lacuna in the community's utilization of services, despite the fact that National
Tobacco Control Programme (NTCP) provides nationwide cessation services. This demonstrates theneed for extensive community-based tobacco cessation activities.
Keywords:Smokelesstobacco(SLT), Addiction,Quit Attempt, National Tobacco Control Programme(NTCP)