bluuebunny/crossref_metadata_2025 huggingface dataset:
Semantic Context Can Mask Intelligibility Declines at Above-Conversational Speech Levels in Normal-Hearing Listeners
Authors: Fereczkowski Michal , Neher Tobias
Published: May 2023

Purpose:

While speech audibility generally improves with increasing level, declines in intelligibility are inconsistently observed at above-conversational levels, even in listeners with normal audiograms (NAs). The inconsistent findings could be due to different types of speech materials, ranging from monosyllabic words to everyday sentences, used across studies. Here, we hypothesized that semantic context can “mask” intelligibility declines at high levels by constraining plausible response options.

Method:

Intelligibility was assessed in speech-shaped noise with monosyllabic words, sentences without semantic context, and sentences with semantic context. Two presentation levels were used: 80 and 95 dB SPL broadband. Bandpass filtering was applied to minimize upward spread of masking. Twenty-two young adults with NAs were tested.

Results:

Poorer performance at the higher level was found with the monosyllabic words and context-free sentences but not with the context-rich sentences. The scores obtained at the higher level with the two context-free materials were strongly correlated. The correlation was independent of the lower-level scores, suggesting that the high-level performance declines reflect “normal” auditory functioning.

Conclusions:

Young adults with NAs show intelligibility decreases at above-conversational levels when tested with speech materials without semantic context. Top-down processing as facilitated by context information can mask such declines.
Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks
Authors: Hua Zhidan , Han Mingming , Song Lanlan , Yan Yongle , Chen Honglang , Wang Jilong , Li Chao , Chen Yanfan , Yan Hanhan , Chen Mayun
Published: May 2023

Hypoxic pulmonary hypertension (HPH) is a life‐threatening disease that occurs due to a lack of oxygen in the lungs, leading to an increase in pulmonary vascular resistance, right ventricular failure, and ultimately death. HPH is a multifactorial disorder that involves multiple molecular pathways, making it a challenge for clinicians to identify effective therapies. Pulmonary artery smooth muscle cells (PASMCs) play a crucial role in HPH pathogenesis by proliferating, resisting apoptosis, and promoting vascular remodelling. Curcumin, a natural polyphenolic compound, has shown potential as a therapeutic agent for HPH by reducing pulmonary vascular resistance, inhibiting vascular remodelling, and promoting apoptosis of PASMCs. Regulation of PASMCs could significantly inhibits HPH. However, curcumin has the disadvantages of poor solubility and low bioavailability, and its derivative WZ35 has better biosafety. Here, Cu‐based metal organic frameworks (MOFCu) was fabricated to encapsulate the curcumin analogue WZ35 (MOFCu@WZ35) for the inhibition of PASMCs proliferation. The authors found that the MOFCu@WZ35 could promote the death of PASMCs. Furthermore, the authors believed that this drug delivery system will effectively alleviate the HPH.
3D physico-chemical model of a pre-stellar core
Authors: Jensen S. S. , Spezzano S. , Caselli P. , Grassi T. , Haugbølle T.
Published: May 2023

Context. Pre-stellar cores represent the earliest stage of the formation process of stars and planets. By characterizing the physical and chemical structure of these cores, we can establish the initial conditions for star and planet formation and determine to what degree the chemical composition of pre-stellar cores is inherited by the later stages.

Aims. We aim to determine the underlying causes of spatial chemical segregation observed in pre-stellar cores and study the effects of the core structure and external environment on the chemical structure of pre-stellar cores.

Methods. A three-dimensional (3D) magnetohydrodynamic model of a pre-stellar core embedded in a dynamic star-forming cloud was post-processed with a sequentially continuum radiative transfer, a gas-grain chemical model, and a line-radiative transfer model. The results were analyzed and compared to observations of CH3OH and c-C3H2 in L1544. We compared nine different chemical models to the observations to determine which initial conditions are compatible with the observed chemical segregation in the prototypical pre-stellar core L1544.

Results. The model is able to reproduce several aspects of the observed chemical differentiation in L1544. Extended methanol emission is shifted towards colder and more shielded regions of the core envelope, while c-C3H2 emission overlaps with the dust continuum, which is consistent with the observed chemical structure. Furthermore, these results are consistent across a broad spectrum of chemical models. Increasing the strength of the interstellar radiation field or the cosmic-ray ionization rate with respect to the typical values assumed in nearby star-forming regions leads to synthetic maps that are inconsistent with the observed chemical structure.

Conclusions. Our model shows that the observed chemical dichotomy in L1544 can arise as a result of uneven illumination due to the asymmetrical structure of the 3D core and the environment within which the core has formed. This highlights the importance of the 3D structure at the core-cloud transition on the chemistry of pre-stellar cores. The reported effect is likely to affect later stages of the formation process of stars and planets through chemical inheritance.
Gas, dust, and the CO-to-molecular gas conversion factor in low-metallicity starbursts
Authors: Hunt L. K. , Belfiore F. , Lelli F. , Draine B. T. , Marasco A. , García-Burillo S. , Venturi G. , Combes F. , Weiß A. , Henkel C. , Menten K. M. , Annibali F. , Casasola V. , Cignoni M. , McLeod A. , Tosi M. , Beltrán M. , Concas A. , Cresci G. , Ginolfi M. , Kumari N. , Mannucci F.
Published: May 2023

The factor relating CO emission to molecular hydrogen column density, XCO, is still subject to uncertainty, in particular at low metallicity. In this paper, to quantify XCO at two different spatial resolutions, we exploited a dust-based method together with ALMA 12-m and ACA data and H I maps of three nearby metal-poor starbursts, NGC 625, NGC 1705, and NGC 5253. Dust opacity at 250 pc resolution was derived based on dust temperatures estimated by fitting two-temperature modified blackbodies to Herschel PACS data. By using the HI maps, we were then able to estimate dust-to-gas ratios in the regions dominated by atomic gas, and, throughout the galaxy, to infer total gas column densities and H2 column densities as the difference with HI. Finally, from the ACA CO(1–0) maps, we derived XCO. We used a similar technique with 40 pc ALMA 12-m data for the three galaxies, but instead derived dust attenuation at 40 pc resolution from reddening maps based on VLT/MUSE data. At 250 pc resolution, we find XCO ∼ 1022 − 1023 cm−2/K km s−1, 5–1000 times the Milky Way value, with much larger values than would be expected from a simple metallicity dependence. Instead, at 40 pc resolution, XCO again shows large variation, but is roughly consistent with a power-law metallicity dependence, given the Z ∼ 1/3 Z⊙ metal abundances of our targets. The large scatter in both estimations could imply additional parameter dependence, which we have investigated by comparing XCO with the observed velocity-integrated brightness temperatures, ICO, as predicted by recent simulations. Indeed, larger XCO is significantly correlated with smaller ICO, but with slightly different slopes and normalizations than predicted by theory. Such behavior can be attributed to the increasing fraction of CO-faint (or dark) H2 gas with lower spatial resolution (larger beams). This confirms the idea the XCO is multivariate, depending not only on metallicity but also on the CO brightness temperature and beam size. Future work is needed to consolidate these empirical results by sampling galaxies with different metal abundances observed at varying spatial resolutions.
The Effects of Beneish’s M-Score Model and Financial Ratio Analyis on Fraudulent Financial Statement Indications
Authors: Lumadi Kezia Aviel , Rusgowanto Fransisca Hanita
Published: May 2023

The aim of this research was to collect empirical evidence on the effects of Beneish’s M-Score Model that was calculated using the eight formulas that come with it and of financial ratio analysis based on the indicators financial leverage, profitability, asset composition, liquidity, and capital turnover on fraudulent financial statement indications in manufacturing companies in the consumer goods sector listed on the Indonesia Stock Exchange over the period 2017–2020. The dependent variable in this research was a dummy variable, where a score of 1 was assigned to a company which restated its financial statements and a score of 0 was assigned to a company that did not perform any restatement. The research results showed that only the variable financial leverage had a significant effect on fraudulent financial statement indications. Meanwhile, Beneish’s M-Score Model did not have any significant effect on fraudulent financial statement indications. Data analysis in this study used STATA (Statistics Data Analysis) software version 16 which was used to perform statistical data tests.
The Utilization of The Kano Model for Development of Edible Spoon
Authors: Allwin  , Aurellia Crezentia Audrey , Romulo Andreas
Published: May 2023

The use of plastic in food packaging and cutlery is one of the significant factors that cause environmental pollution. The alternative solution that can be given to reduce the use of plastic is to create edible spoons. The features and attributes required for the spoon are essential factors in the process of product development. Therefore, this study aimed to analyze the level of consumer acceptance and satisfaction regarding the features and attributes of the product by using the Kano method. This analysis involves distributing questionnaires, validity and reliability tests, and dividing requirements into specific categories. The requirements distributed in the questionnaire are various dimensions of product quality that need to be analyzed in product development. The results of the Kano questionnaire showed that of the 17 requirements, there were five essential attributes: having a BPOM certificate, hygienic packaging, a list of nutritional contents on the package, the good nutritional content on the edible spoon, and a product that is not easy to stale. These five attributes are the ones that should be considered in developing edible spoon products.
Machine Learning Application in Battery Prediction: A Systematic Literature Review and Bibliometric Study
Authors: Kamul Azure , Hananda Nico , Harito Christian , Djuana Endang , Elwirehardja Gregorius Natanael , Pardamean Bens , Gunawan Fergyanto E. , Budiman Arief S. , Asrol Muhammad , Redi A. A. N. Perwira , Pasang Tim
Published: May 2023

Recently, the popularity of li-ion batteries has attracted many researchers to carry out the battery’s maximum potential. Predicting batteries condition and behavior is part of the process that is considered challenging. ML algorithm is widely applied to overcome this challenge as it demonstrates a successful outcome in optimizing the complexity, accuracy, reliability, and efficiency of battery prediction. Yet, we believe there is a particular research area of battery prediction that can further be explored and enhanced with machine learning capability. Therefore, we perform a systematic literature review and bibliometric study to uncover the gap in the machine learning application in the battery prediction field. This study is divided into four stages: (1) literature search from the Scopus Database, (2) filtering the results based on keywords and prepared criteria using PRISMA method, (3) systematic review from filtered papers to provide further understanding, and (4) bibliometric analysis from visualization created in VOSViewer software. The analysis findings determine battery safety and performance prediction as a potential gap in the scope of machine learning for battery prediction research and provide some insightful information to assist future researchers. We envision this study to encourage further battery research, which will assist in the creation of better, cleaner, safer, and long-lasting energy resources.
Classification Algorithm Analysis for Breast Cancer
Authors: Sukmandhani Arief Agus , Lukas  , Heryadi Yaya , Suparta Wayan , Wibowo Antoni
Published: May 2023

Breast cancer in women is a type of disease that is the main cause of death in women according to world breast cancer data. Therefore, early detection of breasts is needed significantly to improve life. If a woman has been identified, then rehabilitation and treatment on an incentive basis are needed to reduce the worse. This study used a dataset collected by the University of Wisconsin Hospitals, Madison (https://atapdata.ai/). This research conducted experiments using several data mining classification strategies to predict breast cancer using machine learning algorithms. The Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Naive Bayes, Random Forest, Decision Tree, Deep Learning (H2O), and Neural Network are used to classify algorithms. From these algorithms’ classification, we compare accuracy, best classification, and compare algorithm performance with curve ROC (RapidMiner Studio Core) to see which performance algorithm has the best quality for classification. From the analysis results, the deep learning algorithm with Tanh and Exprectifier activation function has a good accuracy of 93.14%, and the best classification with 89.62%. In addition, deep learning has found the best quality from the ROC curve results on the dataset used in this research.
The Study of Customer Satisfaction on Natural Skincare Products for MSME’s E-Business Sustainability
Authors: Dharmono Stanley Christian , Putra R. Aditya Kristamtomo , Herdina Ajeng Mira
Published: May 2023

The Covid-19 pandemic causes all activities carried out online and increases the demand for natural skincare products. E-business is a promising business model during the pandemic and post-pandemic for MSMEs that sell skincare products made from natural ingredients. This research aimed to define the influence of quality and price of natural skincare products on customer satisfaction, which can support the sustainability of MSMEs' E-business. The object of this research is Zavennie, an MSME that sells green skincare products using the B2C E-business model. This study uses a quantitative approach by employing a survey distributed through an online questionnaire. The respondents of this research are customers who have bought Zavennie products. The data analysis method applied in this research is multiple linear regression. The results revealed that product quality and price partially and simultaneously had a significant influence on customer satisfaction. The findings in this study also indicate that improving product quality and determining the proper selling price could support the sustainability of MSMEs' E-Business which produces skincare products made from natural ingredients. The findings of this study will provide a reference for MSMEs that operates E-Business to enhance product quality and determine appropriate selling price to maintain customer satisfaction. For further study, it is suggested to apply a wider research object and involve more respondents to gain a deeper insight regarding factors that influence customer satisfaction and its impact on the sustainability of MSMEs E-Business model.
Does e-Commerce Capability Mediate The Strategic Orientation to Performance and Hybrid Channel to Performance? (An Empirically Analysis of Micro and Small Businesses in Indonesia)
Authors: Wimpertiwi Dotty , Arief Mts. , Alamsjah Firdaus , Setiowati Rini
Published: May 2023

Today, e-commerce has been used as a fast vehicle to transform the world that significantly affects businesses, including small businesses. Many challenges and problems are faced, especially in terms of dealing with e-commerce, such as there is much lack of knowledge about developing technology, customer demand, and human and financial resource management. However, after the pandemic Covid-19 situation, entrepreneurs must rise from adversity, fast, and quickly adapt to the situation. In previous research, Entrepreneurial Orientation, Market Orientation, Learning Orientation, and a combination, Strategic Orientation had a positive and significant effect on Performance. Likewise, Hybrid Channel had a positive and significant effect on Performance. Furthermore, successful entrepreneurs adopt e- commerce in their business development or e-Commerce Capabilities. The purpose of this paper is to prove empirically whether the variable of e-Commerce Capability in mediating the Orientation Strategy or Hybrid Channel to performance in the context of micro and small businesses. The paper used SEM Analysis Covariant Based Structural Equation Modelling (CB-SEM) to test a hypothesis and AMOS as a statistical tool. The data states that the important factors affecting performance, especially micro and small entrepreneurs, are strategic orientation and the use of hybrid channels. However, the data has not been able to show that e-commerce capability can mediate the effect of both on performance.
Trapping Insider Trading Perpetrators with Misappropriation Theory, Is That Possible?
Authors: Riyanto Agus , Santo Paulus Aluk Fajar Dwi , Suwardi
Published: May 2023

In Indonesia, insider trading is a crime that the perpetrators do not easily catch. This is sourced from the theory of fiduciary obligations in Article 95 of Law no. 8 of 1995 concerning the Capital Market and restrictions on insider trading. In the United States, using the abuse theory in Sections 10(b) and Sections 10b-5, the Securities and Exchange Act of 1934 can reach anyone, without limitation, which is categorized as an insider trader. The main purpose of this paper is to find new ideas about the existing obstacles to ensnare insider trading actors that have been happening in Indonesia so far. For this reason, the method used is to compare regulations and insider trading cases in the two countries. This study shows that it is time for Indonesia to adopt the theory of misappropriation as an alternative to trapping insider trading actors in the capital market. This urgency is needed to foster investor confidence in the growth and development of the Capital Market in Indonesia.
Systematic Literature Review and Research Agenda of Corporate Governance in Indonesia
Authors: Anastasia Regina , Hapsari Tri
Published: May 2023

This study aims to provide a comprehensive overview from various studies in the scope of corporate governance in the Indonesian market using systematic literature review method. This study provide insights about Indonesian corporate governance studies phases, identify gaps, and suggest outlines for future agenda research. There are 37 studies include in this systematic literature review study. The study used after doing an assessment of the quality, based on predetermined criteria. Furthermore, the studies used will be extracted to collect the methodology, theories, characteristics, and results of the research. From this study, we can conclude that in general, Indonesian good corporate governance led companies to improve its financial performance positively. Even the corporate governance code also encourages companies to produce voluntary disclosures in various fields. From this review, a conclusion can be drawn from the research which mentions the results that contradict with the theories and the general results of the research. The gaps in the results are caused by the differences in methodologies, sample, and study period. Further, this condition can be explained by the presence of moderating variables in the form of Indonesia's political and economic conditions.
Self-Efficacy and Subjective Norm as Mediators in the Role Model and Entrepreneurial Intention Link (A Case of Balinese Students)
Authors: Bagia Ketut Meira Sukma , Pangaribuan Christian Haposan , Putra Okta Prihatma Bayu , Hidayat Desman
Published: May 2023

Several studies show entrepreneurship contributed significantly to economic growth. The increasing number of entrepreneurs can improve the economic condition in some countries. However, In Indonesia, the number of entrepreneurs compared to other countries in South Asia, such as Malaysia, Thailand, Vietnam, and the Philippines, are still low. Therefore, it is essential to analyze factors that might drive people’s intention to become an entrepreneur. Prior studies had examined entrepreneurial intention from some perspectives. Hence, this study tries to examine factors that might influence entrepreneurial intention, such as role models, self-efficacy, and subjective norms, by modifying the TPB framework model. In addition, this study also examines the variable of subjective norm and self-efficacy as the mediating variable of role model to entrepreneurial intention. This study implements a quantitative approach and collects sample data from university students in Bali. The total number of respondents for the sample data is 150. Moreover, the study results show that role model, subjective norms, and self-efficacy positively significantly influence students’ entrepreneurial intention. The result also shows that the role model is positive and significantly influences subjective norm and self-efficacy. The findings of this research can provide recommendations for government and universities to enhance students’ entrepreneurial intention.
Representation of Radical Environmentalism inPom PokoandFirst Reformed
Authors: Nararya Mohammad Alvian Dharma , Imanjaya Ekky
Published: May 2023

In the age of social media and streaming platforms, the visuality of an idea has become much more important than before, including in the space of environmental activism. The representation of an ecoactivism idea campaigning for climate change, including the more radical practice of those activisms, is now communicated mainly not with written words but through the audio-visual medium of film or vlog to the audience. In the realm of cinema, films are worth analyzing regarding their representation of radical environmental activism Pom Poko (1994) directed by Isao Takahata, and First Reformed (2017) by Paul Schrader, because of their originality and nuanced representation of radical environmental activism. Through these films, we can see not only the surface representation of radical environmentalism but also the philosophy and reason behind it that usually has been overlooked. The authors chose both films to highlight that radical environmentalists' ideology and actions have been depicted relevantly since 1994 and continue in 2017 and beyond. Using hermeneutics reading of the text and Bordwell’s four levels of meanings, we found that the cinema, specifically fictional films, can be an effective tool to represent the nuanced idea of environmentalism and radical environmentalism as much as its documentary counterpart.
An Analyze on Japan Comprehensive Economic Partnership (AJCEP) First Amendment Protocol Toward Japan-ASEAN Cooperation
Authors: Willman Teungku Natasya , Mursitama Tirta Nugraha
Published: May 2023

This research aims to identify and analyze Japan's interests in the first amendment protocol to the ASEAN – Japan Comprehensive Economic Partnership (AJCEP) agreement using the study of political economy and international diplomacy. Japan's need for natural resources cannot be met alone. Therefore, Japan needs to cooperate with other countries that produce all-natural resources and cheap labor to meet their needs. This Japanese-owned motive invites questions. The method used in this research is a descriptive qualitative method with data collection through a literature study. This study indicates that they have economic and political interests in AJCEP cooperation, but even though Japan is politically and economically superior, ASEAN and Japan continue to work together for Japan's security and politics between Japan and ASEAN.
Applying the UTAUT to Understand Factors Affecting the Use of Indonesia Public Administration
Authors: Marsintauli Frihardina , Diennia Risha Noor , Sujarminto Aditya
Published: May 2023

Decision-making will always be based on valid and reliable data. Information disclosure is a necessity for people in a country to know something. Through a system, a country will be greatly assisted in disseminating information to its people. The transparent public administration process is the hope of the citizen to the government. Innovation based on the use of the system plays an essential role in fulfilling government-owned social services. Claiming Old Age Security during the pandemic has forced the government to use a system that can run a fast and controlled administrative process. This study wants to evaluate a system used in the employees' social services of state-community administration using the UTAUT method. This study indicates that the performance expectancy, social influence, facilitating conditions, and behavior variables have a significant and positive effect. However, the effort expectancy variable does not influence behavior intention. The optimal system is a system that can be used easily by users; if the data processor cannot use the system, a system failure will occur because the data generated will be biased and invalid. Suppose the user has difficulty operating the system. In that case, it is best to immediately evaluate it in the form of input and training to improve further the skills of the user who uses it. Participants who process claims can be processed faster, increasing participant satisfaction.
Data-driven development of sparse multi-spectral sensors for urological tissue differentiation
Authors: Fischer Felix , Frenner Karsten , Granai Massimo , Fend Falko , Herkommer Alois
Published: May 2023

Infrared spectroscopy is often used to spot differences between benign and malignant tissue. Due to the proliferation of tumorous cells, the composition of tissue changes drastically. In the consequence shifts occur in its optical properties that are indicated by spectral biomarkers in the so-called fingerprint region. In this work, we propose a new concept for a sparsified multi-spectral measurement of the most important and informative biomarker signals. The results of a data-driven feature selection approach show that a reliable discrimination of the tissue is still possible, even though utilizing only a small fraction of the measured data. A selected arrangement of only a few narrow-band quantum cascade lasers could provide proficient signal-to-noise ratios and can noticeably reduce the data acquisition time. Consequentially, real-time applications will be possible in short-term and in-vivo diagnostics in the long-term. First measurements of silicone phantoms validate the imaging capability of the sensor concept.
The role of deformation in the microstructure, mechanical properties, and shape memory characteristics of Cu-Al-Ni shape memory alloys
Authors: Al-Mahdi Mohammed R. , Ahlatci Hayrettin , Saud Al-Humairi Safaa N.
Published: May 2023

Due to its potential high-temperature applications, Cu-Al-Ni shape memory alloys have recently attracted much interest. This article attempts to investigate the different percentages of deformation of 1%, 2%, and 4%. on the microstructure, mechanical properties, and shape memory effect of Cu-13wt.% Al-4wt.% Ni shape memory alloys. The findings indicated that the deformed specimen performed much better than the homogenized sample. From microstructural observations, it is seen that the β1′ (18R) and γ1′ (2H) martensite phases as needles- and plates-like morphologies coexisted at different fractions in the undeformed and deformed states. Furthermore, the transformation temperature curves have shifted toward higher transformation temperatures as the deformation percentage increases. The deformed alloy exhibits good mechanical properties with high ultimate tensile strength and ductility after deformation at 2% and 4%, respectively. The microhardness of the deformed samples exhibited the lowest hardness of 247.6 Hv at a 4% deformation percentage. However, it exhibits ductile fracture, including mixed intergranular and transgranular features with linear stress-strain behaviour after applying a 4% deformation percentage. The shape recovery of 94.6% of the original length was achieved when a 2% of the deformation was applied. Because of this, it is reasonable to expect that the mechanical properties and shape-memory attributes of Cu-based SMAs are drastically affected by deformation.
Hemodynamic Effects and QTc Changes with Intravenous Phenytoin and Fosphenytoin during Propofol and Sevoflurane Anesthesia
Authors: Maremanda Krishna R. , Geetha Singam , Reddy Bakkireddy S. , Durga Padmaja , Bramarambha Kolli L.
Published: May 2023

Background Phenytoin is a commonly used antiepileptic drug (AED) for postoperative seizure prophylaxis; it is associated with adverse cardiovascular effects. Fosphenytoin is considered a safer alternative but can produce prolongation of QT interval. This hypothesis generating pilot study evaluated the changes in hemodynamics and the heart rate corrected QT interval (QTc) with phenytoin and fosphenytoin during propofol and sevoflurane anesthesia.

Methods Eighty American Society of Anesthesiologists I and II patients aged 20 to 60 years undergoing elective supratentorial craniotomy requiring a loading dose of the intraoperative AED for seizure prophylaxis were randomized into four groups: group PP, receiving propofol (0.2 mg/kg/min) for maintenance and phenytoin (15 mg/kg) for seizure prophylaxis; group SP, receiving sevoflurane (1 minimal alveolar concentration) for maintenance and phenytoin(15mg/kg) for seizure prophylaxis; group PF, receiving propofol for maintenance and fosphenytoin (22.5 mg/kg) for seizure prophylaxis; and group SF, receiving sevoflurane for maintenance and fosphenytoin for seizure prophylaxis. The heart rate, systolic, diastolic, mean arterial pressure, and QTc were measured at baseline before anesthesia, during maintenance of anesthesia, and during various phases of AED infusion and up to 1 hour after completion of AED administration. Appropriate statistical analysis was done and a two-tailed p-value of less than 0.05 was considered significant.

Results The incidence of changes in the heart rate and hypotension was not significant among the groups. Administration of fosphenytoin significantly prolonged QTc, which was more remarkable when coadministered with sevoflurane than with phenytoin.

Conclusion Fosphenytoin did not confer hemodynamic benefits over phenytoin. Fosphenytoin produces prolongation of QTc, and when coadministered with sevoflurane, the prolongation is more significant, suggesting a possible additive effect.
Failure of Sequential Compression Device Detected by Neuromonitoring during Minimally Invasive Posterior Scoliosis Surgery
Authors: Raue Kristen D. , Shils Jay , Fessler Richard G.
Published: May 2023

Intraoperative neuromonitoring is recommended as standard practice for corrective scoliosis surgery. Common methods include somatosensory-evoked potentials (SSEPs) and transcranial motor-evoked potentials (TcMEPs), which have been shown to have a high diagnostic accuracy in detecting new neurological deficits postoperatively. Sequential compression devices (SCDs) are a common method for thromboprophylaxis in spine surgery and are not known to have many device-related complications. To date, there have been no reports of lower extremity ischemia secondary to SCD deflation failure detected by multimodality neuromonitoring during minimally invasive posterior spine surgery. We, therefore, present a case report of an 18-year-old male with adolescent idiopathic scoliosis who underwent minimally invasive posterior spinal fusion with instrumentation. Intraoperative decrease in SSEPs and TcMEPs were noted in the left leg shortly after incision before any instrumentation or reduction occurred. Further examination revealed that the left leg was hypoperfused compared with the right leg and that the left SCD was not properly deflating. Bilateral SCDs were removed, and perfusion and neuromonitoring returned to baseline immediately. Bilateral SCDs and the machine were replaced, and neuromonitoring remained within normal limits for the rest of the surgery. The patient had no postoperative neurologic or vascular deficits. Early detection of lower extremity ischemia by neuromonitoring resulted in the prompt identification and addressing of SCD malfunction, sparing devastating neurological and vascular injury to the patient's leg. This case reinforces the importance of neuromonitoring within spine surgery.
Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature
Authors: Bhattacharjee Sukrita , Ghosh Shouriyo , Ray Siddhartha Sankar , Samanta Sambit , Sinha Nilanjan , Saha Sandeep , Bhattacharyya Maitreyee
Published: May 2023

Acute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discuss the individual patients in detail and the challenges faced during their treatment. The use of established lymphoblastic leukemia treatment protocols and the modifications made therein to prevent untoward chemotherapy-related toxicities to the fetus are discussed in this study. We report the second use of rasburicase during pregnancy in literature with favorable maternal and fetal outcomes. We also present an extensive literature review of 41 cases of ALL in pregnancy previously reported. It is important to note that there is a dearth of guidelines for the treatment of these complex situations, and although certain general principles can be established, an individualized approach is needed in most cases of leukemia diagnosed during pregnancy.
Effect of a Patient Navigator Program to Address Barriers to Eye Care at an Academic Ophthalmology Practice
Authors: Zarnegar Arman , Cassidy Julie , Stone Andre , McGinnis-Thomas Dana , Wasser Lauren M. , Sahel José-Alain , Williams Andrew M.
Published: May 2023

Purpose The aim of this study was to determine whether a patient navigator program can address patient-reported barriers to eye care and to understand patient perceptions of a patient navigator program in ophthalmology.

Design This is a retrospective cohort study and cross-sectional patient survey.

Subjects and Methods A cohort of patients was recruited from a single academic ophthalmology department in the Mid-Atlantic region. Patients included in the study had received referral to the patient navigator program in the first quarter of 2022. Our patient navigator program provided patients with resources to address barriers to care such as transportation and financial assistance. Outcomes of the study included indications for referral, case resolution rate, and patient satisfaction.

Results In total, 130 referrals for 125 adult patients were included. The mean ± standard deviation age was 59 ± 17 years, 54 (44%) were male, 77 were white (62%), and 17 patients (14%) were uninsured. Common reasons for referral were transportation (52, 40%), insurance (34, 26%), and financial assistance (18, 14%). Among the 130 cases referred, 127 (98%) received an intervention from the patient navigator, who was able to resolve the referring issue in 90% of cases (117/130). Among 113 patients contacted for a follow-up telephone survey, 56 (50%) responded. Patients rated the program highly at a mean Likert rating of 4.87 out of 5. Moreover, 72% (31/43) of respondents stated their interactions with the patient navigator assisted them with taking care of their eyes.

Conclusions A patient navigator program can address barriers to eye care by connecting patients with community resources.
Dirofilaria repens in a Pediatric Patient—First Case Report from Switzerland
Authors: Rose Rebekka , Kleitsch Kai-Uwe , Born Diana , Heye Pascal
Published: May 2023

We report the first case of Dirofilaria repens in a 4-year-old male patient in Switzerland. The disease is a vector-borne parasitic infection that is not endemic to Switzerland. A 4-year-old male presented with a tender mass in the left groin. The patient was taken to the operating room for surgical exploration to rule out a pathology that could be harmful to the spermatic cord. A node was found along the spermatic cord and excised. Histopathology and microbiology studies revealed the diagnosis of Dirofilaria repens.

Even though Switzerland is not endemic to Dirofilaria repens, the diagnosis of a parasitic infection should be considered in patients presenting with subcutaneous nodules in correlation with a travel history to endemic areas. The treatment consists of complete excision of the affected tissue.
Large Cyst of Skene Gland: A Rare Perineum Mass
Authors: Tzelepis Konstantinos , Zacharouli Konstantina , Samara Athina A. , Koutras Antonios , Kontomanolis Emmanuel N. , Perivoliotis Konstantinos , Pavlidou Efterpi , Sotiriou Sotirios
Published: May 2023

Objective In this report we present a rare case of a large cyst of Skene gland in a female patient with a palpable vaginal mass persisting for at least 2 years.

Case Report A 67-year-old female admitted to the department of urology due to the presence of “a vaginal mass” for the past 2 years. A cyst of Skene's duct was suspected based on clinical manifestation and findings of magnetic resonance imaging showing an extensive cyst formation in the upper vaginal area and anterior to the urethra. Based on these findings, a decision for surgical removement of the cyst was made. The cyst was incised, drained, and marsupialized. The postoperative recovery was uneventful, and the patient was discharged on the second postoperative day.

Conclusion High clinical suspicion is important to reach this rare diagnosis. Partial excision and marsupialization of the cyst is a simple procedure with low morbidity, without recurrence, and excellent results.
Impact of Ablation during Index Hospitalization on All-Cause Mortality in Patients with Typical Atrial Flutter: Insights from National Multicenter Database
Authors: Amer Muhammad , Annie Frank H. , Adhikari Shubash , Mukherjee Debabrata
Published: May 2023

Background We sought to assess the impact of ablation during index hospitalization (IH) on all-cause mortality (ACM) in patients presenting with newly diagnosed typical atrial flutter (tAFL) as compared with patients without ablation, irrespective of optimal rate or rhythm control medications.

Methods We identified patients with newly diagnosed tAFL in the TriNetX Research Network between January 20, 2010, and January 20, 2021. Using International Classification of Diseases, 10th revision (ICD-10) codes, patients were stratified into those who had undergone ablation during IH and those who did not undergo the procedure. Results were assessed using propensity score matching (PSM) analysis as well as Kaplan–Meier curves.

Results A total of 12,986 (N) patients (aged 35–85 years) met our inclusion criteria. Of those, 3,665 had undergone ablation during IH compared with 9,321 patients who did not. Patients in the ablation group (mean age 64.3 ± 10.1 years) had a higher prevalence of hypertension (80 vs. 78.3%, p = 0.02), respectively. PSM created two well-matched groups of 3,652/3,652 patients each with an ACM of ablation of 4.5 versus 7.8% (p = 0.01) at 6 months, 6.6 versus 11.4% (p = 0.01) at 12 months, and 14.5 versus 20.9% (p < 0.001) at 36 months of follow-up. Survival data were confirmed through Kaplan–Meier analysis using a log-rank test.

Conclusion From a large, federated, multicenter population database, we report significant survival benefit of ablation during IH in patients presenting with new tAFL diagnosis. Kaplan–Meier mortality curves confirmed survival advantage with ablation at 6, 12, and 36 months of follow-up in this cohort.
Modeling and investigating electric power output maximization for piezoelectric energy harvester
Authors: Al Anazi Abeer Abdullah , Candra Oriza , Chammam Abdeljelil , Marhoon Haydar Abdulameer , Ali Inas Ridah , Al-Kharsan Ibrahim H. , Alayi Reza , Ebazadeh Yaser , Aladdin Morteza
Published: May 2023

In this study, energy harvesting using a two-layer piezoelectric sensor in non-linear single-mode mode was investigated, and the optimal performance conditions for power extraction were investigated. Non-linear equations or non-linear electric enthalpy proposal were obtained using Lagrange’s method. In addition, the model was identified with the help of perturbation methods and based on experimental results. The results indicate the presence of second-order damping and third-order stiffness with magnitudes of 2.8 × 106 and −3.9 × 1021. Finally, non-linear energy harvesting was investigated, and the electrical resistance for an optimal electrical power of 185.2 was obtained.
Long-lived molecular anions of brominated diphenyl ethers
Authors: Asfandiarov N. L. , Muftakhov M. V. , Pshenichnyuk S. A.
Published: May 2023

Resonance electron attachment in a series of brominated diphenyl ethers, namely 4-bromodiphenyl ether (BDPE), 4-bromophenyl ether (BPE), and decabromodiphenyl ether (DBDE), was investigated in the gas phase by means of dissociative electron attachment spectroscopy. In addition to channels of dissociation into stable fragments, long-lived molecular negative ions with an average lifetime relative to autodetachment of the order of 60 µs were found for the last two molecules. In the case of BDPE and BPE, the most intense dissociation channel is the bromine anion, and for DBDE—the [C6Br5O]− anion. The [C6Br5O]− anion sequentially decomposes with the elimination of the bromide anion on a microsecond time scale, which is confirmed by the registration of metastable ions with an apparent mass of 12.8 a.m.u. The electron affinity of the studied molecules and the appearance energy of fragment ions were estimated with CAM-B3LYP/6-311+G(d,p).
Person restrictions in non-canonical agreement patterns in
Spanish
Authors: Ausín Adolfo , Depiante Marcela
Published: May 2023

In this paper we present empirical evidence for
the existence of person restrictions across five constructions which
exhibit non-canonical agreement patterns in Spanish. We account for
these data by adopting a Multiple Agree approach à la
Anagnostopoulou (2005,
2017) and D’Alessandro (2007) where
T/INFL can agree with two different elements as long as there is no
person feature incompatibility.

We also show that there are person restrictions
in non-canonical agreement constructions with
parecer in Spanish (contra Mare and Pato, 2018), once
we set aside the “look-like” interpretation of
parecer. In addition, we provide empirical
evidence for the claim that usted(es) behaves as an
“imposter” as expected by Collins and Ordóñez (2021) analysis.
The emergence of sound change in two varieties of Spanish
Authors: Pollock Matthew , Delgado-Díaz Gibran , Galarza Iraida , Díaz-Campos Manuel , Willis Erik W.
Published: May 2023

We examine social and linguistic factors,
including lexical frequency, that influence variable production of
the alveolar rhotic trill in Caracas, Venezuela, and the region
surrounding Caguas, Puerto Rico. Two categories of rhotic
productions are established: non-innovative trills with two or more
occlusions and innovative reduced ones with fewer than two
occlusions and possible frication. Phonetic context, rhotic
duration, and lexical frequency conditioned trill production in both
varieties; mixed-effect logistic regressions showed that shorter
duration and high frequency tokens predicted use of innovative
variants in both varieties, while low vowels also did so in Caracas.
This suggests that Caracas and Caguas are experiencing variation
reflective of the early stages of a linguistic change, with
linguistic factors conditioning reduced variants.
Promoting Spanish L2 pragmatic competence in a virtual
environment
Authors: Collentine Karina , Collentine Joseph
Published: May 2023

Virtual Environments (VE) can mimic the myriad
dimensions that native speakers take into account in authentic
social interactions and are one of the instructional conditions
(e.g., methodological approaches, learning affordances) that can be
used to promote pragmatic competence. The present study employs
big-data techniques to provide a parsimonious and quantifiable model
of affordance usage in VEs fostering L2 Spanish learners’ pragmatic
abilities. We employ data-reduction analyses to synthesize tracking
data that recorded learners’ use of software features within
consciousness-raising and structured-input, both involving
task-based language teaching (TBLT). The analysis suggests that
three macro variables can significantly classify different learning
conditions: (i) movement through the VE, (ii) type of interaction
with affordances providing input, (iii) time on task.
Effectiveness of exergames programme to modify body composition and health‐related physical fitness in adolescents with down syndrome after COVID‐19 quarantine
Authors: Suarez‐Villadat Borja , Sadarangani Kabir P. , Villagra Ariel
Published: May 2023

Aims: to determine the effect of a 20‐week exergame program on different indicators of body composition and components of health‐related physical fitness in adolescents with Down syndrome. Methods and Procedures Outcomes: 49 adolescents (19 female and 30 males; average age, 14.19 ± 2.06 years) with Down syndrome were recruited and randomized to two groups (control group vs. intervention group). Adolescents allocated in the control group carried out a physical activity program three times a week for 20 weeks meanwhile adolescents allocated in the exercise group performed an exergame program three times a week for 20 weeks. Results: The exercise group had significant improvements in all health‐related physical fitness variables and there is an improvement in some body composition variables (p < 0.05). Conclusions and Implications: 20 week exergame program consisting of 3 sessions of 60 minutes is able to improve levels of body composition and health‐related physical fitness in adolescents with Down syndrome.

Highlights

Research in body composition and health‐related physical fitness of people with Down syndrome has revealed that an exergame programme increases levels of health‐related physical fitness in adolescents with Down syndrome

An exergame programme can improve differences in markers of body composition between the control group and the intervention group

The intervention group that performed the exergame programme showed increases in health‐related physical fitness levels after 20 weeks of intervention.

The control group that performed a based on developing motor behaviour programme did not show differences in body composition or health‐related physical fitness after 20 weeks of intervention.
The C10orf76–PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi
Authors: Mizuike Aya , Sakai Shota , Katoh Kaoru , Yamaji Toshiyuki , Hanada Kentaro
Published: May 2023

Phosphatidylinositol 4-monophosphate [PtdIns(4)P] is a precursor for various phosphoinositides but also a membrane-embedded component crucial for membrane contact sites (MCSs). Several lipid transfer proteins are recruited to MCSs by recognizing PtdIns(4)P; however, it remains poorly elucidated how the production of PtdIns(4)P for lipid transport at MCSs is regulated. Following human genome-wide screening, we discovered that the PtdIns(4)P-related genes PI4KB, ACBD3, and C10orf76 are involved in endoplasmic reticulum-to-Golgi trafficking of ceramide by the ceramide transport protein CERT. CERT preferentially utilizes PtdIns(4)P generated by PI4KB recruited to the Golgi by C10orf76 rather than by ACBD3. Super-resolution microscopy observation revealed that C10orf76 predominantly localizes at distal Golgi regions, where sphingomyelin (SM) synthesis primarily occurs, while the majority of ACBD3 localizes at more proximal regions. This study provides a proof-of-concept that distinct pools of PtdIns(4)P are generated in different subregions, even within the same organelle, to facilitate interorganelle metabolic channeling for the ceramide-to-SM conversion.