bluuebunny/crossref_metadata_2025 huggingface dataset:
ELEMENTS OF THE MACEDONIAN SECURITY IDENTITY (ATTATCHMENT TO THE FOUNDATION OF THE MACEDONIAN SECURITY HISTORY)
Authors:   Faculty of Security - Skopje, Mojanoski Cane , Arizankoski Goce ,   Ministry of Internal Affairs
Published: August 2023

The paper is an attempt to determine the security identity of the Macedonian state and the Macedonian society, i.e., a synthesis of the essential elements of the structure of the Macedonian security identity from the establishment of the independence of the Macedonian state until today. We define Macedonian security identity as a coherent organization of recognizable and relatively unchangeable security relevant elements that refer to: national values and the resulting permanent, vital and important interests of the Macedonian society and state; the national security policy, i.e., the goals and areas for its realization (functioning); the holders of the national security policy, i.e., the institutional set-up of the national security system; the legal-normative and conceptual-doctrinal regulation, as well as the regulation of the strategic positions and determinations of the national security system; the national security forces; the subjects of security in the Macedonian society and state; forms of security threats, risks and dangers) to national security; long-term phenomena present in the Macedonian society and state generated by the security-threatening and security-stimulating influence of the global, regional and immediate environment; the constants that participate in achieving, maintaining and promoting the internal political (instability) in the Macedonian society and state; active and equal membership in the North Atlantic Treaty Organization (NATO); the strategic commitment and goal of the Macedonian society and state for political, economic and security integration in the European Union (EU); regional cooperation and relations with the neighboring countries; the security opportunities of the Macedonian society and state; the economic power and prosperity of the Macedonian state; the establishment and implementation of the security sector control; and the legal-normative and functional-organizational set-up of security in the private sector in the Macedonian society. Key words: Macedonian security identity, Macedonian state, Macedonian society
FAN GROUPS AS A TOOL FOR IMPLEMENTATION OF THE POLITICAL AGENDA AND CAUSING SECURITY CRISIS
Authors:   Faculty of Law – Kicevo, Petrevski Blagojche , Stanojoska Angelina ,   Faculty of Law – Kicevo
Published: August 2023

Fan groups, or supporters’ groups, in their composition mobilize people from different social, economic, educational, and ultimately political structure. They are "interest groups" in a country which deserve attention. The scientific community in the past and today explores and analyzes fan groups from different aspect. The issue that we will primarily analyze in the paper refers to the relation between a political party and fan groups. The dilemma who, when, and for what purpose uses fan groups, as well as the questions related to the reasons for cooperation between political parties and fan groups will be presented through certain examples that are current (primarily in the Republic of Serbia). Also, through presentation of a historical digression we will try to present the continuity of "cooperation" of political parties with fan groups. The paper will also offer some considerations about fan groups as a potential "soft-power" tool that can be "used" by external factors to provoke a political and security crisis. The possibilities for institutional reaction in prevention of the influence of fan groups on certain political processes that we will present as a conclusion in the paper will offer certain solutions, ways and opportunities to eliminate or ultimately reduce the close cooperation between political parties and fans groups. Keywords: fan groups, politics, cooperation, institutional response.
30 YEARS OF MACEDONIAN STATEHOOD: FUTURE SECURITY CHALLENGES
Authors:   Faculty of Security - Skopje, Sviderski Mihajlo , Petrevski Blagojce
Published: August 2023

The process of creating the Macedonian state begins with the disintegration of the SFR Yugoslavia and the Referendum for Independence on September 8, 1991.As a geographically integral part of the Western Balkans, the Macedonian state was exposed to challenges of a different nature. Since the day of the declaration of independence, the country has been facing with certain issues that in the past period have proven to have the potential to cause serious internal political and security crises.Today, the dilemma is whether after full NATO membership we can hope for a more secure future from a political, and at the same time from a security and economic point of view, or still the challenges, primarily interethnic relations, remain as such. In that regard, the potential for the existence of hybrid threats that the Macedonian state could face as a NATO member should be considered.The perception and forecasts for the future of the Republic of North Macedonia are different. Through this paper we will try to answer some of the questions and challenges that the state would face in the coming period. In particular, in this paper we will present the possible positive changes that may occur in the country, but at the same time we will address the potential risks with which the state is facing, relating to the change of political i.e. state governance of the country as a consequence of a possible new interethnic conflict. Keywords: Macedonian statehood, Interethnic relations, Security challenges, Hybrid threats, NATO
THE MEDIA INFLUENCE ON PUBLIC ATTITUDES ABOUT PUNITIVENESS
Authors:   Faculty of Security - Skopje, Peovska Natasha , Bacanovic Oliver , Trajanovska Vesna ,   Faculty of Security - Skopje,   International Balkan University (IBU)
Published: August 2023

Public attitudes about punitiveness have a significant impact on penal policy in the societies. Punitive penal policy and increased imprisonment of offenders are often seen as a reflection of the public support for harsh punishment. (Cullen et all, 2000). Criminological research often links the attitudes toward punishment with the socio-demographic characteristics of the public (gender, age, race, ethnicity, political ideology, education, income, religion), their possible direct or indirect victimization, the fear of crime, their perceptions about crime and the effectiveness of the criminal justice system. In addition to these factors, in the last two decades the attitudes have also been linked with the increasing presence and use of the media The empirical research analyzes the issue of the connection between the media consumption and shaping public attitudes toward punishment, especially for certain crimes. Hence, the subject of this paper is the impact of media consumption on the public attitudes about punishment, with the purpose to determine to what extent and in what direction is that influence. The impact of different types of media and different types of media content or programs on public attitudes about punitiveness will be analyzed. In general, the research shows that different types of media and news, such as watching television news (local and national) and crime-related programs, have influence on the attitudes about punishment (Intravia, 2019). However, the direct impact cannot be fully and clearly determined, because the research uses a different methodology in terms of the media consumption and media content. In addition to traditional media, from research perspective, special attention is given to the connection between the use of social media and their impact on punitiveness. The importance of analyzing their impact on public attitudes is primarily due to the increasing number of individuals who use social media, which are a major source of crime-related news and often providing access to news or information shared by others. These features related to social media (especially social networks) allow individuals to virtually participate in issues related to crime and punishment, which in turn can change someone's opinion and position on the topic of discussion. (Anderson & all, 2014).
Semantic analysis of terms in dietetics: nutritional status and nutritional condition
Authors:   Federal Research Center of Nutrition, Biotechnology and Food Safety, Moskow, Russian Frderation, Petukhov A.B. , Novodranova V.F. ,   A.I.Yevdokimov Moscow State University of Medicine and Dentistry, Moskow, Russian Federation,   Institute of Linguistics of the Russian Academy of Sciences, Moskow, Russian Federation, Nikityuk D.B. ,   Federal Research Center of Nutrition, Biotechnology and Food Safety, Moskow, Russian Frderation
Published: August 2023

The necessity of semantic analysis of the language of science is logically substantiated. The complexity and multi-level interpretation of definitions is demonstrated, as well as the need for linguistic description of terms in dietetics to achieve mutual understanding by specialists. Key words: language of science, nutritional science, dietetics, terminology, nutritional status, nutritional condition
Normas de Derecho Tributario para discapacitados y su desarmonía con el Derecho Internacional de los Derechos Humanos en Uruguay
Authors: Vizcarret Tessore Lorena
Published: August 2023

El objetivo de este trabajo es comprobar la existencia de una desarmonización entre las normas de Derecho Internacional de los Derechos Humanos y parte de las normas del derecho tributario uruguayo que reglan las exoneraciones a los vehículos para discapacitados. La Convención sobre los Derechos de las Personas con Discapacidad, la Constitución uruguaya y las normas emanadas de los órganos internos del Estado, cualquiera que sea su jerarquía, deben aplicarse facilitando el derecho a la movilidad. En consonancia, Uruguay adoptó dos modalidades de exoneración, según surjan de la potestad nacional o de la potestad de los gobiernos departamentales. Esta última presenta problemas de armonización desde 2018, con la entrada en vigencia e incorporación de los vehículos nacionalizados al Sistema Único de Cobro de Ingresos Vehiculares. Para cumplir con el objetivo descrito, el método se basó en la investigación cualitativa integrada por la exploración transversal, descriptiva e interpretativa que recoge la tradición uruguaya en la armonización del Derecho Internacional de los Derechos Humanos con las normas internas, comparando el estudio analítico del caso mencionado. Como conclusión, se observa una regresividad en la aplicación de las normas citadas que no llegan a darle una solución satisfactoria al problema.
Dissection of novel genetic regions and superior alleles related to high grain number per spike in a new wheat-Agropyron germplasm Pubing3228
Authors: Wang Jiansheng , Wang Erwei , Cheng Shiping , Ma Aichu
Published: August 2023

Agropyron cristatum (L.) can be used as a valuable gene resource for broadening the genetic basis of common wheat in breeding programs. Pubing3228 is a new elite wheat-Agropyron hybrid germplasm that possesses many desirable agronomical traits, includingthe grain number per spike (GNS), the main yield component. Uncovering the genetic architecture of GNS in Pubing3228 is important for increasing wheat yield through molecular assisted breeding. In the present study, genetic regions and alleles associated with high GNS from Pubing3228 were analyzed using a recombination inbred line (RIL) population derived from the cross between Pubing3228 and Jing4839. In total, 75 QTLs were identified for GNS. These QTLs mapped to 21 chromosomes (i.e.,all except for 5B and 6A) and explained 3.30–17.17% of the total phenotypic variation. Five QTLs (QGns.wa-1D, QGns.wa-5A, QGns.wa-7D.1, QGns.wa-7D.2, and QGns.wa-7D.3) explained more than 10% of the phenotypic variation in at least two environments. Pubing3228 contributed 94.67% of the total number of QTLs associated with GNS. Candidate gene analysis was conducted for the stable QTLs, and 11 candidate genes were obtained for GNS. Among these 11 genes, a senescence-associated protein gene (TraesCS7D01G148000) linked with the most significant single nucleotide polymorphism (SNP) AX-108748734 on chromosome 7D was relevant to remobilizing the nutrients from the senescing tissues to the developing seeds. The findings of this study will not only provide new insights into the genetic mechanism of high GNS of Pubing3228 but willalso be useful for marker-assisted selection for yield improvement in breeding practice.
Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors
Authors: Stockner Thomas , Gradisch Ralph , Schlögl Katharina , Lazzarin Erika , Niello Marco , Maier Julian , Mayer Felix , Silva Leticia Alves da , Skopec Sophie , Blakely Randy , Sitte Harald , Mihovilovic Marko
Published: August 2023

The presynaptic serotonin (5HT) transporter (SERT) clears extracellular 5HT following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter homeostasis. Clinically approved drugs used for the treatment of neurobehavioral disorders, including depression, anxiety, and obsessive-compulsive disorder that target SERT trap the transporter in the outward-open state thus blocking the transport cycle. In contrast, illicit drugs of abuse like amphetamines reverses SERT directionality, thereby causing 5HT efflux. Both result in an increase of extracellular 5HT levels. Stoichiometry of the transport cycle has been described by kinetic schemes, whereas the structures of the main conformations provide only static coordinates of molecular features of the process. By combining in-silico molecular dynamics modelling approaches with in-vitro and ex-vivo biochemical experiments and making use of a homologous series of 5HT analogues, we uncovered the essential coupling mechanism between the substrate and the transporter triggering the uptake process. The free energy calculations showed that only scaffold-bound substrates can correctly close the extracellular gate. Attractive forces acting on the bundle domain through long-range electrostatic interactions tilt the bundle domain towards the scaffold domain. The associated spatial requirements define substrate and inhibitor properties, enabling new possibilities for rational drug design approaches.
A Survey of Ownership and Utilization of Insecticide Treated Nets (ITNs) Among Pregnant Women Attending ANC Clinic
Authors: Diebieri Maximous , Alhassan Barikisu Ategtoore , Ayamba Monica Salamatu , Antwi Faustina Mensah
Published: August 2023

This study sought to assess the ownership and utilization of insecticide treated nets among pregnant women attending antenatal care clinic A cross-sectional study design was adopted to conduct the study METHODS: A structured questionnaire was used to collect data from 185 pregnant women. The data were presented by means of descriptive statistics. Findings showed that 93.5% of the pregnant women owned at least an ITN with 90.3% owning more than one ITN prior to the survey. However, 6.0% of the pregnant women slept under ITN the night before the survey. A combination of personal, household, and institutional factors accounted for the poor usage of the ITNs
Left atrial dissection : An unique complication of mitral valve surgery
Authors: Aljasem Hazem , Ali-Ghosh Hani , Ohri Sunil
Published: August 2023

Background: Left atrial dissection is an unique but an extremely rare complication associated with cardiac surgery especially mitral valve surgery.
Case Presentation: Here we presented a case report of a 76-year old lady who had mitral valve surgery complicated with left atrial dissection managed surgically. Interestingly, we proposed a new classification of left atrial dissection which could guide the surgeon in the management of this complication.
Conclusions: left atrial dissection might be a lethal complication associated with mitral surgery and can be managed surgically and non surgically depending on the clinical courser and haemodynamic state. The new proposal can help the surgeons to put the management plan.
Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages
Authors: Park Woong-Yang , Nguyen Truc , Park Hyun Jung , Lee Dong-Sup , Shah Nameeta , Mandzhieva Bayrta
Published: August 2023

Tumor-associated macrophages (TAMs) play vital roles in cancer tissue homeostasis, immunosuppression, and angiogenesis in the tumor microenvironment. Here, we utilize single-cell transcriptomics to present an atlas of healthy and pan-cancer myeloid cell populations, revealing their remarkable heterogeneity. We uncovered the dual origins of TAMs including C1QC+ TAMs derived from resident tissue macrophages, and SPP1+ TAMs and ISG15+ TAMs derived from blood monocytic populations. The differentiation of immature myeloid-derived suppressor cells (MDSCs) to TAMs is also elucidated, with THBS1+ MDSCs and SPP1+ TAMs shown to play critical roles in immunosuppression and angiogenesis and are associated with worse survival in many cancer types. Additionally, this study reveals the presence of a monocytic subtype, BAG3+ Mono, that undergoes cellular stress during the differentiation into M2 macrophages and is linked to poor survival rates in multiple cancer types and inferior response to immune-checkpoint blockade (ICB) therapy. Overall, this study offers critical perspectives into the intricate interplay between various monocyte-macrophage cell subtypes.
Construction of an immune prediction model for osteosarcoma based on coagulation-related genes
Authors: Jiang Ye , Wang Xinyu , Li Yang , Lu Shiyuan , Chen Chunzheng , Lin Liangxin , Yang Qifan , Wang Hongbo , Zhu Dong
Published: August 2023

Objectives
The prognostic outcome of osteosarcoma, as the most common primary malignancy in children and adolescents, has not improved better with the development of modern medical care, and the aim of this study was to investigate the role of the coagulation system in the diagnosis and development of osteosarcoma.
Methods
TRGET and GEO databases were used to acquire clinical information and matching RNA data from osteosarcoma patients. To find novel molecular groupings based on coagulation systems, shared clustering was used. TIMER, SSGSEA, CIBERSORT, QUANTISEQ, XCELL, EPIC, and MCPCOUNTER analyses were used to identify the immunological status of the identified subgroups and tumor immune microenvironment (TIME). To understand the underlying processes, functional studies such as GO, KEGG, and protein-protein interaction (PPI) network analysis were used. Prognostic risk models were built using the LASSO technique and multivariate Cox regression analysis.
Results
The survival rates of the two molecular groupings were considerably different. large immunological scores, poor tumor purity, a large number of immune infiltrating cells, and a reasonably good immune status were all related with a better prognosis. According to GO and KEGG analyses, DEGs between the two groupings were primarily enriched in immunological and extracellular matrix-related pathways. Risk models based on coagulation system-related genes (CRGs) show promise in predicting osteosarcoma survival. A nomogram that combines risk models and clinical data may reliably predict the prognosis of individuals with osteosarcoma.
Conclusion
In patients with osteosarcoma, the expression of genes associated to the coagulation system is strongly related to the immunological milieu and can be utilized to correctly predict the prognosis of osteosarcoma.
Neuroprotective Role of Metformin in a Model of Cerebelar Ataxia
Authors: Atella Tainá Correa , Medina Jorge Mansur , Atella Georgia Correa , Allodi Silvana , Kluck George E. G.
Published: August 2023

Cerebellar ataxia is a heterogeneous group of neural disorders clinically characterized by cerebellar dysfunction. The diagnosis of patients with progressive cerebellar ataxia is complex due to the direct correlation with other neuron diseases. Although there is still no cure for this pathological condition, some metabolic, hereditary, inflammatory, and immunological factors affecting cerebellar ataxia are being studied and which may become therapeutic targets. Advances in studying the neuroanatomy, pathophysiology, and molecular biology of the cerebellum contributes to better understand the mechanisms behind the development of this disorder. In this study, we analyzed the neuromodulatory role of the AMP-activated protein kinase (AMPK) on cerebellar ataxia induced by the neurotoxin 3-acetylpyridine (3-AP) in brain stem and cerebellum, after pre-treatment with metformin, a pharmacological indirect activator of AMPK. The results shown here suggest that AMPK activation in the brain stem and cerebellum leads to a significant reduction in neuroinflammation in these regions. AMPK was able to restore the changes in fatty acid composition and pro-inflammatory cytokines caused by 3-AP, suggesting that the action of AMPK seems to result in a possible neuroprotection on the cerebellar ataxia model.
Analysis of the Fertility Intention and Influencing Factors of Urban Women of Childbearing Age in Liaoning Province under the “Three-child” Policy
Authors: Yuan Cheng , López-Carr David
Published: August 2023

Background:
In the context of implementing the "Three-Child" policy and promoting urban-rural integration, has the fertility intentions of women of childbearing age in Liaoning Province changed? What are the main influencing factors impacting their fertility choices? Are there more people who "don't want to have children" or "are afraid to have children"? Under the multiple push and pull forces of policy intervention, cultural change, and rational choice, which side are their fertility intentions more inclined towards?
Methods:
Through a sample survey of 1,104 urban women of childbearing age in four cities in Liaoning province (Shenyang, Dalian, Fuxin, and Fushun), the fertility intentions and influencing factors of this group were statistically described using cross-tabulation and multiple regression models, and in-depth interviews were conducted with 24 typical cases.
Results:
About 10% of urban women of childbearing age shifted from "never considering having a third child" to "considering having a third child"; less than 10% of urban women of childbearing age explicitly stated "they would definitely have a third child"; more than 70% of urban women of childbearing age explicitly stated, "they would not consider having a third child". The factors that significantly influence fertility intentions are subjective, such as the level of concern regarding children’s impact on freedom and quality of life, opinion of three child policy, and level of traditional values regarding childbirth; the less obvious factors are objective, such as average monthly income, years of education, migration experience.
Conclusions:
First, the number intentions from strong to weak, are 2 children, 1 child, and 3 children. Second, the gender intention from strong to weak is: having both a boy and a girl, only a boy, and only a girl. Third, in terms of the combination of quantity and gender, the intention from strong to weak is 1 boy and 1 girl, 1 boy, and 2 girls, …and 0 girl and 3 boys. Fourth, in terms of the length of the birth interval, the intention from strong to weak is 3 to 4 years, 5 to 6 years, 1 to 2 years, and over 6 years.
Research on the Synergistic Effect of Urbanization and the Ecological Environment in City Clusters: A Case Study of the Chengdu-Chongqing City Cluster Based on the Haken Model
Authors: Wu Weilong , Huang Ying , Zhang Yuzhou , Zhou Bo
Published: August 2023

The development of urbanization and the protection of the ecological environment are important aspects of sustainable development in city clusters, and their coordination and synergy are crucial to achieve this. Regarding the relationship between urbanization and the ecological environment, scholars both in China and internationally have conducted extensive research from the perspective of coordinated development. However, there is a lack of research on the synergistic effects of urbanization and the ecological environment. Taking the Chengdu-Chongqing city cluster as an example, this study uses the Haken model to analyze the synergistic evolution mechanism, development patterns, and future trends of urbanization and the ecological environment. This study draws the following conclusions: (1) while a synergistic development mechanism has been established between urbanization and the ecological environment, the current system is still in a stage of low-level synergy, and the control system’s parameter for the direction and path of evolution is urbanization. (2) From 2001 to 2020, the level of synergistic development between urbanization and the ecological environment was relatively low, mainly moving from low-level synergy to medium-low-level synergy to medium-level synergy. (3) There is a significant spatial disparity in the levels of synergistic development, for which the leading region centers on Chengdu and Chongqing in the northwest and southeast, respectively, and the lagging region comprises the eastern part of the city cluster, mainly represented by Dazhou, Kaizhou, and Yunyang. (4) The future trend of synergistic development between urbanization and the ecological environment in the Chengdu-Chongqing city cluster is promising but requires increased infrastructure construction in mountainous urban areas, enhanced cooperation and circulation in transportation, logistics, information and other aspects, and balanced improvements in the level of synergistic development between urbanization and the ecological environment. The study of the synergistic development effect of urbanization and the ecological environment in city clusters is of great significance for reducing the negative impact of urbanization on the ecological environment, increasing the positive interaction between the two, and promoting sustainable development in city clusters.
An Ensemble Clustering Approach for Modeling Hidden Categorization Perspectives for Cloud Workloads
Authors: Daraghmeh Mustafa , Agarwal Anjali , Jararweh Yaser
Published: August 2023

Effectively managing cloud resources is a complex task due to the interdependencies of various cloud-hosted services and applications. This task is integral to workload categorization, which groups similar cloud workloads to inform workload scheduling and resource management procedures. Although traditional clustering algorithms can categorize workloads into single data grouping patterns, the multifaceted nature of cloud workloads may conceal multiple valid categorization perspectives, indicating a need for a more adaptable clustering approach. This paper presents a novel ensemble clustering approach to enhance the scheduling workload categorization process in cloud computing. Our approach combines various normalization and transformation techniques, including principal component analysis, to form multiple data preprocessing pipelines. The data derived from these pipelines then serve as input for multiple base clustering learners. A novel combined score based on the Silhouette score, Calinski-Harabasz index, and Davies-Bouldin index is then employed to select the optimal models and preprocessing setups. The clustering outcomes of these models are encoded and inputted into a meta-clustering algorithm, effectively capturing complex categorization perspectives. Evaluation of this approach using real-world workload trace data from Microsoft Azure significantly enhances workload segmentation efficacy, thereby improving resource management and quality of service in cloud data centers. This method offers a promising pathway toward improved workload clustering in cloud computing, demonstrating the practical utility of advanced ensemble clustering techniques.
The Effects of Organic Selenium supplementation on Immunity, Physico- biochemical properties of Spermatozoa, and Carcass traits in Male Turkeys
Authors: Biswas Avishek , Deo Chandra , Sharma Divya , Nampalle Mukesh T , Tiwari A. K.
Published: August 2023

The effects of dietary organic selenium (Se) on immunological function, the physical and biochemical properties of sperm, and fertility in male turkey birds were investigated in this study.
The source of organic selenium used was seleno-methionine (Se-M). 160 male turkeys (16 weeks old; 3.2 kg on average weight) were chosen at random, and 20 groups of 8 chicks each were created (4 dietary treatments x 5 replicates). The four experimental diets (T1, T2, T3, and T4) were formulated with addition of 0, 0.3, 0.4, and 0.6 mg Se/kg diet, respectively. The birds were kept in individual cages under standard husbandry conditions for duration of 24 weeks, were fed a breeder's ration, and received ad libitum water. At 28 weeks, antibody tires (humoral immunity) were significantly (P≤0.05) increased, whereas the response to intradermally injected phyto-haemagglutinin (during week 29), an index of the in vivo cell-mediated immune response, was shown to be increased in the groups fed Se-M at 0.4 and 0.6 mg Se-M/kg diet (T3 and T4 group). In birds fed 0.6 mg Se-M/kg (T4), the bursa of Fabricius and the thymus had higher relative weights. Physical characteristics such as sperm volume, sperm concentration, sperm motility, and percentage live sperm were significantly higher (P≤0.05) in the T3 group, whereas the proportion of abnormal and dead spermatozoa was significantly lower (P≤0.05) and fertility was higher in the T3 (0.4 mg Se-M /kg). The amount of total protein and testosterone concentrations were significantly (P≤0.05) higher in the T3 group, but sperm creatinine, acid phosphatase (ACP), and alkaline phosphatase (ALP) concentrations did not differ significantly (P≤0.05). However, thio-barbituric acid reactive substance (TBARS), total antioxidant capacity (TAC) and glutathione peroxidase (GSH-Px) concentration were significantly (P≤0.05) higher in T3 group. Thus, it could be concluded that the basal diet with 0.4 mg/kg organic selenium (seleno-methionine) may be beneficial for physical and biochemical characteristics of semen, improved the immunity and fertility in adult male turkeys.
Factors associated with acute postoperative pain in preschool children in a referral clinic in eastern Colombia
Authors: Lizcano Dairon Jose Gelvez , Melendez Hector Julio , Wilches Hector Hugo Torres , Gallardo Paula Andrea Durán , Medina Jhoan S. Hurtado , Santamaría Andrés Felipe Mantilla , Moreno Marlon Jesús Lozano
Published: August 2023

Purpose
Pain is one of the most difficult variables to quantify in the pediatric population, besides being the most determinant parameter of the length of stay in a post-anesthetic recovery room. The aim of this study is to characterize the most determinant variables in postoperative pain in our pediatric population.
Methods
An observational cross-sectional study was conducted in preschoolers and school children operated at Clínica Materno Infantil San Luis in Bucaramanga, between January and June 2018. Postoperative pain was evaluated and characterized using the LLANTO pain scale in addition to other related variables.
Results
Postoperative pain prevalence was 65.6%. Propofol and fentanyl were identified as protective factors to prevent postoperative pain with a RR of 0.55 and 0.44, respectively. The urology and laparotomy surgical groups were associated with less postoperative pain with a RR of 0.63 and 0.6, respectively.
Conclusion
Propofol and fentanyl use was identified as the most important protective factor for postoperative pain. In addition, there is a close relationship between anxiety and postoperative pain. According to the surgery type, it is suggested to use different adjusted anesthetic methods for each case.
Clinical Response to a PARP Inhibitor and Chemotherapy in a Child with BARD1-Mutated Refractory Neuroblastoma: A Case Report
Authors: Federico Sara , Cupit-Link Margaret , Hagiwara Kohei , Zhang Jinghui
Published: August 2023

Despite advances in the treatment of high-risk neuroblastoma, approximately half of these patients die from the disease. Targeted therapy based on synthetic lethality associated with homologous recombination deficiency (HRD) caused by germline mutations in homologous recombination repair genes has shown great efficacy in several adult solid tumors. Here we report the first successful treatment of a pediatric patient with refractory neuroblastoma and a germline pathogenic mutation in BARD1 using a PARP inhibitor, talazoparib, in combination with cytotoxic chemotherapy and radiation therapy. Allele-specific expression in RNA-seq indicates bi-allelic loss of BARD1 in tumor; however, the HRD score was below the threshold currently used for HRD classification in adult cancers. Our study demonstrates that the use of PARP inhibition in combination with DNA-damaging agents should be considered in children with BARD1-mutated neuroblastoma and cautions against the use of HRD score alone as a biomarker for this pediatric population.
The association between Angina and Triglyceride-Glucose Index among non-Diabetic Patients: A NHANES Cross-Sectional study: 2001-2020
Authors: Sawaf Bisher , Swed Sarya , Bohsas Haidara , Alibrahim Hidar , Nasif Mohamad Nour , Ali Eman , Hafez Wael , Hennawi Hussam Al , Tashrifwala Fatema Ali Asgar , Khan Ubaid , Al-Rassas Safwan , Hussain Noor , Zaidi Abdul Rehman Zia , Alghalyini Baraa , Mohamed Waleed Farouk , Othman Mohammed Abdelmoneim M. , Farwati Amr , Seijari Mohammed Najdat , Battikh Naim , Robles-Velasco Karla , Cherrez-Ojeda Ivan
Published: August 2023

Background
A current alternative test of insulin resistance that has been considered a predictor of metabolic syndrome and cardiovascular disease (CVD) is the triglyceride-glucose (TyG) index. However, it is unknown if the TyG index may estimate the risk and incidence of angina in the non-diabetic population. This research examines the correlation between the TyG index and angina in non-diabetic individuals.
Methods
Data from the National Health and Nutrition Examination Survey (NHANES) were used in this study from 2001 to 2020; non-diabetic individuals aged 18 years or older were our targeted sample. We divided the sample regarding the angina as follows: no angina, no exertional chest pain, possible angina, and definitive angina. As well, the categories of TyG index were < = 8.22, 8.23–8.60, 8.61–9.01, and 9.02+. The analysis was conducted using a 4-year weight at fasting (WTSAF4YR) according to NHANES analysis criteria. The receiver operating characteristic (ROC) analysis was utilized to determine the sensitivity and specificity of the TyG index for estimating the endpoints of interest (angina). Univariate and multivariate logistic regression were performed to determine the factors correlated with the study outcomes, and the analysis was performed using IBM, SPSS Version 28.0.
Results
We involved 6,762 non-diabetic individuals, including 49 individuals who had possible angina, and 487 individuals had definitive angina, in addition 1,690 individuals with TyG above 9.02. We addressed a statistically difference between TyG and gender, as 55.9% of participants with high TyG (> 9.02) were males. The Pearson chi-square test showed no statistically significant difference between angina subgroups and TyG index categories, p-value: 0.065. In addition, six regression models confirmed that higher values of TyG index were not associated with the presence of no exertional chest pain, definitive angina, or possible angina. In addition, the TYG test had low diagnostic accuracy for identifying patients with angina (Sensitivity: 52.8%, Specificity: 52.83% AUC; 52.82%, P-value < 0.05).
Conclusion
The TyG index cannot be utilized as an alternate predictive marker for angina in the non-diabetic population since it has no correlation to angina risk factors.
Psychological Distress and Stressor: A Community Based Study of Nepali Migrant Returnees
Authors: Acharya Khagendra , Kharel Arjun
Published: August 2023

The massive outflow of Nepali people as a part of their living strategy is a quite recent phenomenon; scholars have often associated such migration either with the internal conflict that started in 1996 or global economic liberalization towards the end of the century. It was in this decade the six countries of the Gulf Cooperation Council (GCC) and Malaysia became major destinations for migrant workers. Given the nature of acute adversities that Nepali migrant workers like those moving out from developing countries to the developed ones face in these countries, they are often reported to experience distress. This study, through sequential explanatory mixed method, examined the psychological distress of Nepali migrant returnees from nine destinations, namely Malaysia, Qatar, Kuwait, Saudi Arabia, the United Arab Emirates, Oman, Bahrain, Israel and Jordan. Mental health issue was found to prevail among 28.3% returnees. Work related factors – type of visa used to go abroad, income from work, and the nature of return – was observed to have significant association (p < 0.05) with bad mental health status. From the analysis of qualitative data, the themes related to pre-departure, during work, and after the return stressors were identified.
Controlled Large-Area Lithium Deposition to Reduce Swelling of High-Energy Lithium Metal Pouch Cells in Liquid Electrolytes
Authors: Xiao Jie , Liu Dianying , Wu Bingbin , Xu Yaobin , Ellis Jacob , Baranovski Arthur , Lu Dongping , Lochala Joshua , Anderson Cassidy , Baar Kevin , Qu Deyang , Yang Jihui , Aranda Diego , Lopez Katherine , Balbuena Perla , Seminario Jorge , Liu Jun
Published: August 2023

Lithium (Li) metal battery technology has attracted world-wide attention because of its high energy density, but its practical application is hindered by several challenges, with one significant issue being the large volume change and cell swelling. While external pressure is known to have a profound effect on cell performance, there are currently no reports exploring the relationship between external pressure and the electroplating of Li+ in large-format pouch cells to enhance overall performance. Here we investigate the influence of externally applied pressure on the electroplating and stripping of lithium metal in 350 Wh/kg pouch cells. A hybrid constant gap and constant pressure design is designed to apply a minimal external pressure for practical application. The self-generated pressures are monitored and quantified which are further correlated to the observed charge-discharge processes. A two-stage cycling process is observed. In the first stage, Li+ ions utilized are mainly supplied by the cathode which shuttle between the cathode and anode with minimal Li loss which minimizes cell swelling but only happens when pressure is applied appropriately. In the second stage, Li from the Li foil anode participates in the reaction and the thickness of the anode gradually increases. However, even after extensive cycling, cell swelling remains less than 10%, comparable to that of state-of-the-art Li-ion batteries. In addition, the pressure distribution along the horizontal direction across the surface of Li metal pouch cell reveals a complex behavior of Li+ migration during the electroplating (charge) process. The external pressure encourages a preferred plating process of Li in the central region, necessitating the development of new strategies to address uneven Li plating and utilization to advance Li metal battery technology.
The Trail Making Test Part B as a Preclinical Indicator of Alzheimer's Disease and Proxy for Spatial Navigation
Authors: Nevers Jennifer I
Published: August 2023

Background: Preclinical Alzheimer's disease (AD) may create unrecognized risks for physical injury and death due reduction of acetylcholine and disease presence in brain areas involved with spatial navigation (SN). Possible preclinical changes in SN, such as driving, might be indicated by performance on the Trails Making Test Part B (TMT-B). This neuropsychiatric test has time to completion scores associated with at-risk driving ability.
Methods: Linear mixed-effects were performed on TMT-B spanning 1 to 15 years of data on cognitively normal (pre-AD) individuals who later developed AD dementia and compared to those who did not develop the disease (non-AD. Effect size analysis was performed on individual annual time points.
Results: 1104 pre-AD and 14,663 non-AD participants were included ed from the National Alzheimer's Coordinating Center. The pre-AD individuals demonstrated scores associated with at-risk driving. The pre-AD group increased by 3.498 seconds per year, p <.001, whereas the non-AD group increased by 1.845 seconds, p <.001. Effect size range: Cohens d = .217 to .631. Pre-Ad females increased by 3.695 seconds per year, p <.001, .843 p <.001. Effect size range: Cohens d =.383 to .692. Pre-AD males increased by 3.189 seconds per year, p <.001, compared to non-AD males increase of 1.890 seconds, p <.001, with effect size range of Cohens d = 0.259 to 0.520.
Conclusion: The TMT-B may serve as a preclinical screening instrument in longitudinal studies, inform further inquiry for SN risks in this population and correlation with changes in brain acetylcholine levels
A Hybrid GNN Model for Fake News Detection in Digital Media
Authors: B Sathyanarayana K , Ahmed Shoieb , Pradeep H K
Published: August 2023

Newsflash intake from shared mass media is becoming progressively admired now. Public media brings benefits to subscribers precisely to the underlying nature of speedy spreading, inexpensive, and affluent access. In our work, we describe a strong system for recognizing false news summary in the Digital Media that utilizes valuable Graphical based model with Neural Networks. Simulated news is created moreover among rumourmongers or else in the administrative subjects, hence for the undertaking of trailing we have handled dual types of datasets within our methodology. They really are Politifact which contains data related to politics and Gossipicop that contains data related to gossipmongers. We have compiled 5464 samples of Gossipicop compared to 314 samples of Politifact as a greater number of rumourmongers are forged. Three-level Approach is proposed where GCNFN is implemented using two GCN layers and one mean-pooling layer as the graph encoder. The 320-dimensional node feature is composed of 300-dimensional comment word2vec embedding along with 20-dimensional profile features. As the graph coding the GNN-CL is implemented using DiffPool along with profile feature as the node feature. Anticipated Method is judge against the latest work and have established a higher level effectiveness of 94.9% with Ten-Fold verification.
Immunological assessment of recent immunotherapy for colorectal cancer.
Authors: Das Subhadeep , Acharya Diptikanta
Published: August 2023

Colorectal cancer (CRC) is the third most prevalent malignancy with increased incidence and mortality rates worldwide. Traditional treatment approaches have attempted to efficiently target CRC; however, they have failed in most cases owing to the cytotoxicity and non-specificity of these therapies. Therefore, it is essential to develop an effective alternative therapy to improve the clinical outcomes in heterogeneous CRC. Immunotherapy has transformed cancer treatment with remarkable efficacy and overcomes the limitations of traditional treatments. With an understanding of the cancer-immunity cycle and tumor microenvironment evolution, current immunotherapy approaches have elicited enhanced antitumor immune responses. In this comprehensive review, we outline the latest advances in immunotherapy targeting CRC and provide insights into the antitumor immune responses reported in landmark clinical studies. We focused on highlighting the combination approaches to achieve synergistic immune responses and eliminate immunosuppression. This review aimed to understand the limitations and potential of recent immunotherapy clinical studies conducted in the last five years (2019–2023) and to transform this knowledge into a rational design of clinical trials intended for effective antitumor immune responses in CRC.
The Impact Of Sustainability Financial Data Governance, Political Connection On Financial Reporting Quality
Authors: Al-atrsh MotazBellah AbdAlmuiz
Published: August 2023

In the intricate tapestry of organizational dynamics, the pivotal process of decision-making emerges as a linchpin, wielding a substantial influence over companies' viability and enduring success. This study aims to explore the multifaceted factors that underscore sustainable organizational functioning, with a focus on the pivotal role of corporate governance. While the existing literature acknowledges the presence of corporate governance data, a notable gap exists in terms of investigating the nexus between corporate data governance, political affiliations, and their potential impact on financial reporting quality.This research seeks to bridge this gap by conducting a comprehensive inquiry into this complex interplay. Meticulous data collection from 48 carefully selected firms listed on the Palestine Exchange market forms the foundation of this study. Utilizing the analytical capabilities of SPSS, a robust statistical analysis is employed to elucidate the intricate relationship between two central variables: Financial Data Accuracy (FDA) and Political Connection Advantage (PCA).The results of this meticulous analysis illuminate the matter at hand. The intertwined variables exhibit a correlated relationship with financial reporting quality. This correlation not only underscores potential influences on various dimensions but also assumes a pivotal role in the sphere of decision-making within these scrutinized firms. Furthermore, this nexus holds the potential to exert a profound influence on the strategic considerations of these organizations.
Unveiling the Silent Voice: A Rare Case of Speech Disorder in Acute Rheumatic Fever without Structural Damage
Authors: Siddiqui Aisha ,   FARINA FATIMA SIDDIQUI2, SIKANDARI MUHAMMAD HAMZA , SIDDIQUI NOOR-US-SAHAR , KHAN MOMIN
Published: August 2023

Aphonia is a condition that renders an individual incapable of producing sounds. Based on JONES CRITERIA and imaging studies, a conclusive diagnosis of this condition was made in a 13-year-old patient suffering from acute rheumatic fever. The patient exhibited symptoms of chorea, low-grade fever, and aphonia.
Clinical Effects of Postoperative Parenteral Glutamine-Dipeptide Supplementation in Surgical Intensive Care Unit 3 Patients: a Systematic Review and Meta-analysis
Authors: Barone Mirko , Frontera Regina , Liouras Rita Vaia , Serano Luca , Ippoliti Massimo , Dell'Atti Ivan , Vetrugno Luigi , Maggiore Salvatore Maurizio , Mucilli Felice
Published: August 2023

Background- Glutamine plays a vital role as an energy substrate the inflammatory response, prevention of organ injury and renal acid buffering. Parenteral glutamine supplementation could reduce in-hospital and ICU morbidity and mortality.
Objective- Aim of this systematic review and meta-analysis is to investigate the effects of parenteral administration of GLN in adult surgical critically ill ICU patients.
Study selection- Two-arm studies about adult surgical ICU patients undergoing postoperative glutamine-enriched parenteral nutrition (experimental cohorts) vs control ones.
Endpoints- Primary endpoint was in-hospital outcome (mortality, length of stay, length of mechanical ventilation). Secondary endpoint was the evaluation of nosocomial infections.
Results- According to PRISMA ® 2020 flow diagram, eight randomized controlled trials were included for a total of 603 patients. No significant differences about in-hospital and ICU mortality were found (p=0.16 and p=0.53, respectively). Parenteral glutamine-supplementation was associated with a reduction of hospitalization (p=0.02), without influencing nor ICU stay (p=0.35) neither postoperative mechanical ventilation (p=0.18). Finally, dipeptide administration did not reduce cumulative incidence of nosocomial infections (p=0.41); however, a protective role for postoperative pneumonia was reported (p=0.05).
Conclusions- Excepting for a reduction in hospital stay and incidence of nosocomial pneumonia, glutamine-dipeptide parenteral supplementation does not add any benefit in surgical ICU patients.