bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in attitudes toward terrorists: Type of terrorist act, terrorist ethnicity, and observer gender and cultural background
Authors: Levy Inna , Rozmann Nir
Published: January 2022

To explore the interrelationship between terrorist acts, terrorist ethnicity, and observer gender and cultural background in Israel, we recruited 211 participants aged 19–75 years. The majority were male (63%). As for the ethnic and religious cultural background, 40% were Jewish, 40% Druze, and 20% Muslim. The participants answered questions about their demographic characteristics, read three scenarios of terrorist acts, addressed attitudes toward terrorists, and suggested the length of imprisonment. We manipulated the type of act (shooting and killing/burning religious institutions/throwing stones at cars) and terrorist ethnicity (Arab/ Jewish). The results indicate significant main effects of the manipulated variables regarding attitudes toward terrorists. Also, Muslim Arab participants expressed more negative attitudes in cases of Jewish terrorists than Arab terrorists, whereas Jewish participants expressed more negative attitudes toward Arab terrorists than Jewish terrorists. Druze participants did not differentiate between Arab and Jewish terrorists. Furthermore, in cases of Arab perpetrators, Jewish participants suggested imprisonment terms 2.4 times longer than in cases of Jewish perpetrators. The discussion addresses the findings in the context of social identity theory and dual social identification. Regarding practical implications, the findings imply the need for education and training on ethnic bias among policymakers and practitioners.
Market Segmentation of Online Reviews: A Network Analysis Approach
Authors: Wang Hui-Ju
Published: January 2022

With the popularity of online reviews, brand managers have opportunities to segment their markets according to the reviews of their products or services by customers. Nonetheless, it has been suggested that traditional market segmentation methods are ineffective at analyzing online review data due to the complex features and large amount of this type of data; specifically, traditional methods fail to take into account the networked nature of interactive relationships among reviewers and brands across online review websites. Accordingly, this study proposes a network analysis approach for the market segmentation of online reviews. Collecting samples from Yelp via web scraping, this study demonstrates how network analysis techniques can be utilized to segment online reviewers through a four-step process. The results reveal the core and peripheral market segments, as well as the bridge segment in the core. The study contributes to offering marketing researchers and managers a new network structure analysis approach for the market segmentation of online reviews.
Sports Mega-Events and Economic Growth: A Synthetic Control Approach
Authors: Kobierecki Michał Marcin , Pierzgalski Michał
Published: January 2022

This paper contributes to the current literature investigating whether hosting sports mega-events brings tangible economic benefits to the host country. Specifically, we examine whether staging the Olympic Games and the FIFA World Cups leads to observable economic growth. The research has been conducted through a quasi-experimental study in the spirit of the difference-in-differences method. The research subject includes states in which the Olympic Games and FIFA World Cup were held between 2010 and 2016: Canada, South Africa, Great Britain, and Brazil. We found that there is no significant effect of hosting sports mega-events on economic growth.
PHLPP1 Overexpression was Associated With a Good Prognosis With Decreased AKT Activity in Gastric Cancer
Authors: Park Sun Yi , Jeong Sang-Ho , Jung Eun-Jung , Ju Young-Tae , Jeong Chi-Young , Kim Ju-Yeon , Park Taejin , Park Jiho , Kim Tae-Han , Park Miyeong , Yang Jung Wook , Lee Young-Joon
Published: January 2022

Introduction: The aim of this study was to perform a clinicopathologic analysis of PHLPP1 expression in gastric cancer patients and analyze AKT activity with chemotherapy drug treatment in cancer subtypes. Materials and Methods: Surgically resected gastric cancer tissue specimens were obtained from 309 patients who underwent gastrectomy, and PHLPP1 expression was validated by tissue microarray analysis with immunohistochemistry. We assessed whether PHLPP1 selectively dephosphorylates Ser473 of AKT in an in-vitro study. Results: We found that the PHLPP1 overexpression (OE) group showed significantly greater proportions of differentiated subtype samples and early T stage samples, lower lymph node metastasis, and lower TNM stage than the PHLPP1 underexpression (UE) group. The overall survival of the PHLPP1-OE group was significantly higher (53.39 ± 0.96 months) than that of the PHLPP1-UE group (47.82 ± 2.57 months) ( P = .01). In vitro analysis, we found that the PHLPP1-OE group showed a significant decrease in relative AKT S-473 levels in both cell lines (MKN-74 and KATO-III). We found that treatment with chemotherapy drugs decreased the activity of Ser473 in the MKN-74 cell line with PHLPP1 OE, but it did not affect the activity of Ser473 in KATO-III cells. Conclusion: We found that patients who overexpressed PHLPP1 showed low recurrence and good prognosis. PHLPP1 was found to work by lowering the activity of AKT Ser473 in gastric cancer. Additionally, we found a clue regarding the mechanism of chemotherapeutic drug resistance in a cell line of signet ring cell origin and will uncover this mechanism in the future.
Incidence of Recurrent Venous Ulcer in Patients Treated at an Outpatient Clinic: Historical Cohort
Authors: Rocha Michele Neves Brajão , Serna Gonzalez Carol Viviana , Borges Eline Lima , Santos Vera Lúcia Conceição de Gouveia , Rabeh Soraia Assad Nasbine , Nogueira Paula Cristina
Published: January 2022

The recurrence of venous ulcers is the wound reopening after a period of completed epithelisation of a previous ulcer due to exposure to causal factors and lack of prevention. Venous ulcers have a high recurrence rate that may increase through the years. Epidemiological evidence on its incidence and risk factors is scarce due to the lack of patient follow-up in outpatient clinics and adherence to treatment after healing. The objective was to analyze the incidence of venous ulcers recurrency in outpatients and the risk factors for its occurrence. It is an observational historical cohort with retrospective data collection, performed through electronic medical records. Setting: private health insurance outpatient clinic. The participants were adult patients with healed venous ulcers. Incidence of venous ulcer recurrence was calculated within individuals with healed ulcers from 2014 and 2018 with a follow-up of at least one year. Bivariate analysis and logistic regression were used to explore risk factors considering demographic, clinical, and wound-related variables. As a result, sixty-five (65) of the 134 patients with healed venous ulcers had a recurrence, leading to an incidence of 48.5%, with a mean onset time of 230.1 (SD 267) days. Patients with recurrent venous ulcers were primarily women (39/48.1%), with a mean age of 64 (SD 15.5) years, 57 (50.8%) had some comorbidity, with systemic arterial hypertension as the most frequent (47/51%). Obesity (15/88.2%) increased the risk of venous ulcers recurrence by 8.7 (OR 95% CI 2.1-60.8; P = .009) times. In conclusion, venous ulcers recurrence incidence was 48.5%, with obesity as a risk factor. This study demonstrates that the clinical approach of people with venous ulcers should not finish when the wound is healed. For ulcer recurrence prevention interventions addressing systemic factors, besides topical management of the wound, are essential.
A novel design on smooth rotor profile with meshing clearance for screw vacuum pump
Authors: Zhang Li , Liu Yang , Zhang Yongju , Chen Ziyun
Published: January 2022

Cross-section profile of rotor takes a great effect on the performance of dry-screw vacuum pump. A novel smooth rotor profile consisting of eight segments of curves, including arcs and conjugate correction curves is proposed. Advantages are that it can be used to solve the unsmooth connection and no meshing clearance in traditional profile. The meshing model for new profile can directly generate stable addendum clearance, tooth clearance, tooth side clearance, and radial clearance. The influences of the epicycloid rotation angle, arc radius and involute offset distance of the conjugate correction curve on the clearances are studied according to established theoretical model. And transient flow field of vacuum pump is analyzed by using the commercial software Ansys-Fluent®. Compared to traditional screw vacuum pump, the results shows that pressure in inlet and pump cavity is lower, and maximum pumping speed is higher, indicating that the proposed design is superior.
Multiobjective optimization of internal and surface structure of high-speed and heavy-duty brake disc
Authors: Yin Jian , Hao Qiang , Liu Yu , Zhang Shengfang , Sha Zhihua
Published: January 2022

The brake disc plays a crucial role to keep the stable braking of a high-speed and heavy-duty disc brake. There is always high temperature, brake vibration, and even serious deformation under braking pressure and frictional resistance. To improve brake performance, this paper aims to find new internal and surface structures of the brake disc. An equivalent moving load (EML) topology optimization method for internal structure is proposed. Topography optimization method oriented to displacement and stress control for surface structure is carried out. Multiobjective functions containing thermal-structural coupled rigidity and natural frequency of the brake disc are established in the internal and surface structure optimizations. Internal and surface structures of the brake disc are optimized, and the mechanic properties of the brake disc are improved. Thermal-structural coupling and modal analyses are verified with high-speed and heavy-duty brake working conditions. The results show that new brake disc structures meet the requirements, and the effectiveness of the proposed EML topology optimization and topography optimization methods has been proved.
Investigation of approximate mode shape and transition velocity of pipe conveying fluid in failure analysis
Authors: Oke Wasiu Adeyemi , Adeyemi Oluseyi Afolabi , Salau Ayodeji Olalekan
Published: January 2022

Structures dynamic characteristics and their responses can change due to variations in system parameters. With modal characteristics of the structures, their dynamic responses can be identified. Mode shape remains vital in dynamic analysis of the structures. It can be utilized in failure analysis, and the dynamic interaction between structures and their supports to circumvent abrupt failure. Conversely, unlike empty pipes, the mode shapes for pipes conveying fluid are tough to obtain due to the intricacy of the eigenvectors. Unfortunately, fluid pipes can be found in practice in various engineering applications. Thus, due to their global functions, their dynamic and failure analyses are necessary for monitoring their reliability to avert catastrophic failures. In this work, three techniques for obtaining approximate mode shapes (AMSs) of composite pipes conveying fluid, their transition velocity and relevance in failure analysis were investigated. Hamilton’s principle was employed to model the pipe and discretized using the wavelet-based finite element method. The complex modal characteristics of the composite pipe conveying fluid were obtained by solving the generalized eigenvalue problem and the mode shapes needed for failure analysis were computed. The proposed methods were validated, applied to failure analysis, and some vital results were presented to highlight their effectiveness.
Surgical removal of a foreshortened right innominate vein Wallstent causing venous outflow obstruction
Authors: Schafer Kristin , Goldschmidt Eric , Seiwert Andrew
Published: January 2022

Objectives:

Stenting of central venous stenosis to preserve upper extremity hemodialysis access is well-described, though upper extremity complications secondary to these stents are less frequently discussed.

Methods:

We present the case of a 43-year-old male with a right brachiocephalic fistula who developed symptoms of venous hypertension following placement of a Wallstent for central venous stenosis. Workup demonstrated venous outflow obstruction secondary to stent foreshortening into the right subclavian vein.

Results:

The Wallstent was removed in a piecemeal fashion using an open surgical technique and a HeRO graft was placed for dedicated fistula outflow with complete relief of the patient’s symptoms.

Conclusion:

In situations where a stent has migrated and endovascular removal is not possible, individual Wallstent fibers can be removed through a limited venotomy.
Meta-analysis of the diagnostic performance of serum carbohydrate antigen 19-9 for the detection of gallbladder cancer
Authors: Zhou Xiaolei
Published: January 2022

Introduction

Carbohydrate antigen 19-9 (CA19-9) is a well-studied tumor marker, yet its diagnostic value for gallbladder cancer remains unclear. The present meta-analysis was conducted to validate the role of serum CA19-9 for the detection of gallbladder cancer.

Methods

A systematic search of digital databases was conducted, complemented by additional hand-searching. Studies that reported serum CA19-9 for the differentiation of gallbladder cancer cases from non-gallbladder cancer controls were considered eligible.

Results

A total of 27 studies involving 4300 subjects were included. The pooled sensitivity, specificity, and area under the curve in diagnosing gallbladder cancer were 0.70 (95% confidence interval (CI): 0.63–0.76), 0.92 (95% CI: 0.88–0.94), and 0.89 (95% CI: 0.86–0.92), respectively. The pooled positive likelihood rate, negative likelihood rate, and diagnostic odds rate were 8.30 (95% CI: 5.84–11.69), 0.33 (95% CI: 0.27–0.41), and 25.13 (95% CI: 5.83–39.89), respectively. Meta-regression analysis revealed that there was significantly lower sensitivity (0.69, 95% CI: 0.61–0.77) and specificity (0.91, 95% CI: 0.87–0.95) when CA19-9 was used for the differentiation of gallbladder cancer cases from benign biliary diseases. A better specificity of 0.93 (95% CI: 0.90–0.96) was reached in the setting of a sample size ≥100.

Conclusions

Serum CA19-9 can be a potential candidate marker for the detection of gallbladder cancer, which maintains moderate sensitivity and good specificity. Attention should be paid to the control type and sample size, which may affect its diagnostic accuracy. Also, results should be interpreted with caution due to significant heterogeneity primarily caused by different thresholds between included studies.
A survey study of adults with chronic conditions: Examining the correlation between patient activation and health locus of control
Authors: Imeri Hyllore , Holmes Erin , Desselle Shane , Rosenthal Meagen , Barnard Marie
Published: January 2022

Objectives

This study aimed to examine (1) the association between patient activation (PA), health locus of control (HLOC), sociodemographic and clinical factors, and (2) the effect of HLOC dimensions, sociodemographic and clinical factors on PA.

Methods

Three hundred U.S. adults, with at least one chronic condition (CC) were recruited through Amazon Mechanical Turk and completed an online survey which included sociodemographic questions, the Patient Activation Measure® - 10, and the Multidimensional Locus of Control (MHLC) - Form B. Statistical analyses, including descriptive, correlation, and multiple linear regression, were conducted using IBM SPSS v25.

Results

Of the 300 participants, more than half were male (66.3%), White (70.7%), with at least a college degree (76.0%), and employed full-time (79.0%). The average PA score was 68.8 ± 14.5. Multiple linear regression indicated that participants who reported they were Black, retired, with a greater number of CCs, and with higher scores in Chance MHLC had higher PA, while participants with higher scores in Internal MHLC, were unemployed and reported to have been affected by COVID-19-related worry or fear to manage their CC, had lower PA.

Discussion

HLOC dimensions should be addressed concurrently with PA for patients with CCs, thus adding to a more patient-centered clinical approach.
Stroke services in Africa: What is there and what is needed
Authors: Roushdy Tamer , Aref Hany , Kesraoui Selma , Temgoua Michael , Nono Kiatoko Ponte , Gebrewold Meron Awraris , Peter Waweru , Gopaul Urvashy , Belahsen Mohammed Faouzi , Ben-Adji Djibrilla , Melifonwu Rita , Pugazhendhi Sanjeev , Woodcock Noëmie , Mohamed Muhyadin Hassan , Rossouw Anastasia , Matuja Sarah , Ruanda Mark Koba , Mhiri Chokri , Saylor Deanna , Nahas Nevine El , Shokri Hossam
Published: January 2022

Background:

Over the past few years, the incidence and prevalence of stroke has been rising in most African countries and has been reported as one of the leading causes of morbidity and mortality. To study this problem, we need to realize the quality and availability of stroke care services as a priori to improve them.

Methods and Results:

In this study, we investigated the availability of different stroke-related services in 17 countries from different African regions. An online survey was conducted and fulfilled by stroke specialists and included primary prevention, acute management, diagnostic tools, medications, postdischarge services, and stroke registries. The results showed that although medications for secondary prevention are available, yet many other services are lacking in various countries.

Conclusion:

This study displays the deficient aspects of stroke services in African countries as a preliminary step toward active corrective procedures for the improvement of stroke-related health services.
Imaging markers of intracerebral hemorrhage expansion in patients with unclear symptom onset
Authors: Morotti Andrea , Boulouis Gregoire , Charidimou Andreas , Poli Loris , Costa Paolo , Giuli Valeria De , Leuci Eleonora , Mazzacane Federico , Busto Giorgio , Arba Francesco , Brancaleoni Laura , Giacomozzi Sebastiano , Simonetti Luigi , Laudisi Michele , Cavallini Anna , Gamba Massimo , Magoni Mauro , Cornali Claudio , Fontanella Marco M , Warren Andrew D , Gurol Edip M , Viswanathan Anand , Gasparotti Roberto , Casetta Ilaria , Fainardi Enrico , Zini Andrea , Pezzini Alessandro , Padovani Alessandro , Greenberg Steven M , Rosand Jonathan , Goldstein Joshua N
Published: January 2022

Background:

Hematoma expansion (HE) is common and associated with poor outcome in intracerebral hemorrhage (ICH) with unclear symptom onset (USO).

Aims:

We tested the association between non-contrast computed tomography (NCCT) markers and HE in this population.

Methods:

Retrospective analysis of patients with primary spontaneous ICH admitted at five centers in the United States and Italy. Baseline NCCT was analyzed for presence of the following markers: intrahematoma hypodensities, heterogeneous density, blend sign, and irregular shape. Variables associated with HE (hematoma growth > 6 mL and/or > 33% from baseline to follow-up imaging) were explored with multivariable logistic regression.

Results:

Of 2074 patients screened, we included 646 subjects (median age = 75, 53.9% males), of whom 178 (27.6%) had HE. Hypodensities (odds ratio (OR) = 2.67, 95% confidence interval (CI) = 1.79–3.98), heterogeneous density (OR = 2.16, 95% CI = 1.46–3.21), blend sign (OR = 2.28, 95% CI = 1.38–3.75) and irregular shape (OR = 1.82, 95% CI = 1.21–2.75) were independently associated with a higher risk of HE, after adjustment for confounders (ICH volume, anticoagulation, and time from last seen well (LSW) to NCCT). Hypodensities had the highest sensitivity for HE (0.69), whereas blend sign was the most specific marker (0.90). All NCCT markers were more frequent in early presenters (time from LSW to NCCT ⩽ 6 h, n = 189, 29.3%), and more sensitive in this population as well (hypodensities had 0.77 sensitivity).

Conclusion:

NCCT markers are associated with HE in ICH with USO. These findings require prospective replication and suggest that NCCT features may help the stratification of HE in future studies on USO patients.
Applications of a geographic information system–based business intelligence system for decision making at Coffee Refresh
Authors: Chaiprasert Araya , Taweekarn Naphat , Chongwatpol Jongsawas
Published: January 2022

This case is designed to illustrate how to utilize a business intelligence framework and a geographic information system to make better decisions on franchise opening requests. The case started when Jong, the senior certified analytics professional, and his team were drafting a proposal presentation on a new franchise approval process to present to Tony, the director of Coffee Refresh. Currently, Coffee Refresh was experiencing a significant delay in approving franchise opening requests. In addition, the current approval process was relied on the appraisal teams’ evaluations, which involved self-judgment as to the accessibility and visibility of the store location in each franchise opening request and a manual count of the potential targeted customers at each location, which impacted how the appraisal teams estimated the expected revenue for each location. During the first meeting with Jong and his team, Tony was frustrated by the current evaluation process, resulting in a significant backlog of requests pending approval, which was far behind the target for its franchise branch expansion strategy. It had also been reported that the branches that opened during the past few years had a relatively low success ratio (losses between 4.8% and 16.5%) and that the rate of branch closures had increased from 2% to 7.5%. Currently, eight franchise opening requests were pending, and Jong had to provide a recommendation for which requests should be approved. Coffee Refresh could approve all of them instantly, approve some of them, or even decline all of them. This was a great opportunity for Jong and his team to revisit the current franchise approval process and to demonstrate how business intelligence systems could improve the request approval process as well as address the issues of the current franchises’ underperformance and the closure rates.
Consumers are willing to pay a price for explainable, but not for green AI. Evidence from a choice-based conjoint analysis
Authors: König Pascal D , Wurster Stefan , Siewert Markus B
Published: January 2022

A major challenge with the increasing use of Artificial Intelligence (AI) applications is to manage the long-term societal impacts of this technology. Two central concerns that have emerged in this respect are that the optimized goals behind the data processing of AI applications usually remain opaque and the energy footprint of their data processing is growing quickly. This study thus explores how much people value the transparency and environmental sustainability of AI using the example of personal AI assistants. The results from a choice-based conjoint analysis with a sample of more than 1.000 respondents from Germany indicate that people hardly care about the energy efficiency of AI; and while they do value transparency through explainable AI, this added value of an application is offset by minor costs. The findings shed light on what kinds of AI people are likely to demand and have important implications for policy and regulation.
Smartwatch helps detects lung cancer: Using personal technology to advance healthcare
Authors: Cole Andrew Paul Charles , Kar Ashok , Nimako Kofi , Smelt Jeremy
Published: January 2022

Summary

The prevalence of smartwatches and other wearable medical technology has been increasing yearly. These watches offer a sensitive tool for capturing cardiac dysrhythmias and can lead to patients seeking earlier medical advice. This case report highlights the importance of clinicians seeking and using the information provided by wearable medical technology which in this case resulted in both the timely treatment of non-sustained ventricular tachycardia and lung adenocarcinoma.
Prevalence and determinants of ectopic pregnancy in Ethiopia: Systematic review and meta-analysis
Authors: Ayenew Asteray
Published: January 2022

Background:

Ectopic pregnancy is a life-threatening obstetric emergency, and is a major health problem for women of fertile age. Therefore, the aim of this systematic review and meta-analysis was to estimate the prevalence, determinant factors, and outcomes of ectopic pregnancy among fertile age women in Ethiopia.

Method:

International databases (MEDLINE/Pub Med, Hinari, Scopus, Google scholar, African journals, and literatures were searched and nine eligible cross sectional and two case control studies were included in this systematic review and meta-analysis. Eggers test and funnel plot were computed to check publication bias across the studies. Publication bias was computed using a funnel plot and eggers test. Heterogeneity of the studies was checked using Cochrane Q-test and I2 statistic.

Results:

The pooled prevalence of ectopic pregnancy in Ethiopia was 3.61% (95%CI: 2.24–4.98, I2 = 89.2.0%, p < 0.001). Having cesarean section scar (AOR = 7.44, 95%CI: 5.48–10.09), single marital status (AOR = 5.71, 95%CI: 4.76–6.85), history of sexually transmitted infection (AOR = 4.68, 95%CI: 3.04–7.19), history of abortion (AOR = 3.89, 95%CI: 3.35–4.52), history of ectopic pregnancy (AOR = 5.74, 95%CI: 3.81–8.65), and emergency contraceptive use (AOR = 8.72, 95%CI: 2.90–26.20) were the determinant factors for the occurrence of ectopic pregnancy.

Conclusion:

This systematic review and meta-analysis showed that the prevalence of ectopic pregnancy was high in Ethiopia. Thus, educating women to limit the number of sexual partners, smoking cessation, using a condom during sex helps prevent sexually transmitted infections and the risk of pelvic inflammatory disease is crucial.
The Biomechanical Consequences of Arthroscopic Hip Capsulotomy and Repair in Positions at Risk for Dislocation
Authors: Wach Amanda , Mlynarek Ryan , Maher Suzanne A. , Kelly Bryan T. , Ranawat Anil
Published: January 2022

Background:

The effect of interportal (IP) capsulotomy, short T-capsulotomy, and long T-capsulotomy, and their repairs, on resistance to anterior and posterior “at risk for dislocation” positions has not been quantified.

Hypotheses:

Our primary hypothesis was that an IP capsulotomy would have a minimal effect on hip resistive torque compared with both short and long T-capsulotomies in the at-risk dislocation positions. Our secondary hypothesis was that capsule repair would significantly increase hip resistive torque for all capsulotomies.

Study Design

Controlled laboratory study.

Methods:

We mounted 10 cadaveric hips on a biaxial test frame in an anterior dislocation high-risk position (20° of hip extension and external rotation) and posterior dislocation high-risk position (90° of hip flexion and internal rotation). An axial force of 100 N was applied to the intact hip while the femur was internally or externally rotated at 15° per second to a torque of 5 N·m. The rotatory position at 5 N·m was recorded and set as a target for each subsequent condition. Hips were then sequentially tested with IP, short T-, and long T-capsulotomies and with corresponding repairs randomized within each condition. Peak resistive torques were compared using generalized estimating equation modeling and post hoc Bonferroni-adjusted tests.

Results:

For the anterior position, the IP and long T-capsulotomies demonstrated significantly lower resistive torques compared with intact. For the posterior position, both the short and long T-capsulotomies resulted in significantly lower resistive torques compared with intact. Repairs for all 3 capsulotomy types were not significantly different from the intact condition at anterior and posterior positions.

Conclusion:

An IP incision resulted in a decrease in capsular resistive torque in the anterior but not the posterior at-risk dislocation position, in which direction only T-capsulotomies led to a significant decrease. All capsulotomy repair conditions resulted in hip resistive torques that were similar to the intact hip in both dislocation positions.

Clinical Relevance

Our results suggest that it is biomechanically advantageous to repair IP, short T-, and long T-capsulotomies, particularly for at-risk anterior dislocation positions.
Comparison of Lateralized Versus Medialized Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-analysis
Authors: Cho Sung-Hyun , Lee Hyo-Jin , Aldhafian Osama R. , Kim Yang-Soo
Published: January 2022

Background:

Reverse total shoulder arthroplasty (rTSA) is an established procedure for cuff tear arthropathy. More lateralized prostheses have been designed to overcome the reported adverse outcomes of Grammont-style rTSA.

Purpose:

To compare the clinical and radiological outcomes of medialized and lateralized center of rotation (COR) in rTSA.

Study Design:

Systematic review; Level of evidence, 3.

Methods:

This review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Included were studies with a level of evidence ≥3 that compared medialized and lateralized rTSA with a minimum follow-up of 12 months. Functional scores including the American Shoulder and Elbow Surgeons (ASES) score and Constant score (CSS), range of motion at final follow-up, gain of external rotation (ER), visual analog scale (VAS) pain score, scapular notching, and heterotopic ossification (HO) were compared. Data were analyzed using random-effects or fixed-effects models in accordance with heterogeneity.

Results:

Five retrospective cohort studies and 1 randomized controlled study (n = 594 patients) were included. Lateralized rTSA resulted in greater improvement in ER degree ( P < .001), a lower VAS pain score (standardized mean difference [SMD], –0.39; P = .002), and a lower rate of scapular notching (risk ratio [RR], 0.40; P < .001) and HO (RR, 0.52; P < .001). Final forward flexion (SMD, –0.14; P = .629) and ER (SMD, 0.21; P = .238) did not differ significantly between the 2 groups. Overall functional scores, including ASES score (SMD, 0.22; P = .310) and CSS (SMD, 0.37; P = .077), also did not differ significantly (SMD, 0.28; P = .062). The overall complication rate did not differ significantly between the 2 groups (RR, 0.71; P = .339).

Conclusion:

Compared with medialized rTSA, lateralized COR rTSA results in greater improvement in ER and the VAS pain score, decreased rates of scapular notching and HO, and no significant changes in functional outcome scores or the complication rate.
Aging Bodies in Paradise: A Feminist Analysis of Key West’s Fantasy Fest
Authors: Douglas Rachel , Barrett Anne E.
Published: January 2022

Cultural constructions of gender and age may be challenged within politically and socially progressive leisure environments, like Key West, that promote social deviance and out-group acceptance. However, this possibility receives limited scholarly attention. Addressing this gap, our study applies a framework that highlights gender and age as performances and uses interviews ( n = 77) collected in 2017 and 2018 at Key West’s Fantasy Fest, an annual carnivalesque event characterized by body displays of nudity, body paint, and costume. In this first systematic study of Fantasy Fest, data analysis revealed four themes centering on gender, age, and bodies—displaying diverse bodies; judging bodies; limiting body displays; and reinterpreting body-related norms. Key West’s cultural ideology of inclusion allowed both young and old participants to perform gender and age in ways that contributed to a more liberating environment celebrating a range of bodies—though performances were constrained by inequalities. Bodies, especially women’s, were subjected to judgments of their sexual appeal that led some, especially older women, to limit their displays. Our findings, nevertheless, suggest progressive, carnivalesque leisure environments’ potential, however fleeting or bounded, to disrupt everyday performances and broaden conceptions of gendered and aging bodies by reinterpreting the norms surrounding them.
What Do You Want Us to Know?: Learning From Life Stories to Improve Veterans’ Healthcare Experiences
Authors: Rosen Miriam , Nguyen Breanna A. , Khetarpal Susheel , Sgro Gaetan
Published: January 2022

My Life My Story (MLMS) is a national Veterans Health Administration (VA) life story interview program that aims to provide more humanistic care for veterans by focusing on the patient as a person. Our project took place at the Pittsburgh VA Healthcare System and had 3 main goals: (1) describe themes that emerge in MLMS interviews from the prompting question, what do you want your healthcare provider to know about you?; (2) identify topics of importance to veterans and suggest ways for healthcare providers to explore them; and (3) foster a culture at the Pittsburgh VA that places not only the health but also the personal triumphs, hardships, and aspirations of veterans at the center. Veterans provided verbal consent to have their previously recorded stories used in this study. Stories were coded and then analyzed for patterns and themes. A total of 17 veterans participated in our study. Themes that emerged from the stories include (1) Early Hardships; (2) Economic Disadvantage; (3) Polaroid Snapshots; (4) Around the World; (5) Haunted by Combat; (6) Life-altering Moments; (7) Homecoming; (8) Romantic Beginnings & Obstacles; (9) Inequity across Gender & Race; and (10) Facing Mortality. This study's findings underscore the need to address the traumas associated with military service, as well as the challenges faced with re-integration into civilian life, when working with veterans. The MLMS interviews explored in this study can help clinicians identify topics of importance to veterans, strengthen their relationships with their patients, and improve the care that veterans receive.
Application of Optimal-Jerk Trajectory Planning in Gait-balance Training Robot
Authors: Yuan Fu , Chen Diansheng , Pan Chenghang , Du Jun , Wei Xiaodong , Wang Min
Published: January 2022

To accommodate the gait and balance disorder of the elderly with age progression and the occurrence of various senile diseases, this paper proposes a novel gait balance training robot (G-Balance) based on a six degree-of-freedom parallel platform. Using the platform movement and IMU wearable sensors, two training modes, i.e., active and passive, are developed to achieve vestibular stimulation. Virtual reality technology is applied to achieve visual stimulation. In the active training mode, the elderly actively exercises to control the posture change of the platform and the switching of the virtual scene. In the passive training mode, the platform movement is combined with the virtual scene to simulate bumpy environments, such as earthquakes, to enhance the human anti-interference ability. To achieve a smooth switching of the scene, continuous speed and acceleration of the platform motion are required in some scenarios, in which a trajectory planning algorithm is applied. This paper describes the application of the trajectory planning algorithm in the balance training mode and the optimization of jerk (differential of acceleration) based on cubic spline planning, which can reduce impact on the joint and enhance stability.
Tenecteplase vs. alteplase for acute ischemic stroke: a systematic review
Authors: Potla Neha , Ganti Latha
Published: January 2022

Introduction

Thrombolysis for acute ischemic stroke (AIS) with alteplase is the currently approved therapy for patients who present within 4.5 h of symptom onset and meet criteria. Recently, there has been interest in the thrombolytic tenecteplase, a modified version of alteplase, due to its lower cost, ease of administration, and studies reporting better outcomes when compared to alteplase.

This systematic review compares the efficacy of tenecteplase vs. alteplase with regard to three outcomes: (1) rate of symptomatic hemorrhage, (2) functional outcome at 90 days, and (3) reperfusion grade after thrombectomy to compare the efficacy of both thrombolytics in AIS

Methods

The search was conducted in August 2021 in PubMed, filtered for randomized controlled trials, and studies in English. The main search term was “tenecteplase for acute stroke.”

Results

A total of 6 randomized clinical trials including 1675 patients with AIS was included. No one’s study compared alteplase to tenecteplase with all three outcomes after acute ischemic stroke; however, by using a combination of the results, this systematic review summarizes whether tenecteplase outperforms alteplase.

Conclusions

The available evidence suggests that tenecteplase appears to be a better thrombolytic agent for acute ischemic stroke when compared to alteplase.
Targeted Deletion of the First Intron of the Wxb Allele via CRISPR/Cas9 Significantly Increases Grain Amylose Content in Rice
Authors: Liu Xingdan , Ding Qi , Wang Wenshu , Pan Yanling , Tan Chao , Qiu Yingbo , Chen Ya , Li Hongjing , Li Yinlong , Ye Naizhong , Xu Nian , Wu Xiao , Ye Rongjian , Liu Jianfeng , Ma Chonglie
Published: January 2022

Background

The rice Waxy (Wx) gene plays a major role in seed amylose synthesis and consequently controls grain amylose content. Wx gene expression is highly regulated at the post-transcriptional level. In particular, the GT/TT polymorphism at the 5′splicing site of its 1st intron greatly affects this intron’s splicing efficiency and defines two predominant Wx alleles, Wxa and Wxb. Wxa rice often harbours intermediate to high amylose contents, whereas Wxb rice exhibits low to intermediate amylose contents. By deleting the Wx 1st intron using CRISPR/Cas9 technology, we generate a completely novel Wx allele and further investigate how intron removal affects Wx gene expression and rice grain amylose content.

Results

CRISPR/Cas9-mediated targeted deletion of the Wx 1st intron was performed on 4 rice inbred lines: KY131 (Wxb), X32 (Wxb), X35 (Wxa) and X55 (Wxlv). Deletion of the 1st intron occurred in 8.6–11.8% of the primary transformants of these 4 inbred lines. Compared to wild-type plants, amylose content was significantly increased from 13.0% to approximately 24.0% in KY131 and X32 mutant lines, which both carried the Wxb allele. However, no significant difference in amylose content was observed between wild-type plants and X35 and X55 mutant lines, which carried the Wxa and Wxlv alleles, respectively. Wx gene expression analysis of wild-type plants and mutants yielded results that were highly consistent with amylose content results. KY131 and X32 mutants accumulated increased levels of steady mRNA transcripts compared with wild-type plants, whereas steady mRNA levels were not altered in X35 and X55 mutants compared with wild-type plants. Grain quality, including appearance quality and eating and cooking quality, which are tightly associated with amylose content, was also assessed in wild-type and mutant plants, and data were presented and analysed.

Conclusions

This study presents a novel and rapid strategy to increase amylose content in inbred rice carrying a Wxb allele. Our data strongly suggest that the 1st intron of the Wx gene regulates Wx gene expression mainly at the post-transcriptional level in rice. This finding is in contrast to a previous hypothesis suggesting that it influences Wx gene transcription. In addition, removal of the first intron generates a completely novel Wx allele. Further studies on this new Wx allele will provide invaluable insights into the regulation of Wx gene expression, which will help researchers engineer new Wx alleles to facilitate the breeding of rice cultivars with better eating and cooking quality.
gGATLDA: lncRNA-disease association prediction based on graph-level graph attention network
Authors: Wang Li , Zhong Cheng
Published: January 2022

Background

Long non-coding RNAs (lncRNAs) are related to human diseases by regulating gene expression. Identifying lncRNA-disease associations (LDAs) will contribute to diagnose, treatment, and prognosis of diseases. However, the identification of LDAs by the biological experiments is time-consuming, costly and inefficient. Therefore, the development of efficient and high-accuracy computational methods for predicting LDAs is of great significance.

Results

In this paper, we propose a novel computational method (gGATLDA) to predict LDAs based on graph-level graph attention network. Firstly, we extract the enclosing subgraphs of each lncRNA-disease pair. Secondly, we construct the feature vectors by integrating lncRNA similarity and disease similarity as node attributes in subgraphs. Finally, we train a graph neural network (GNN) model by feeding the subgraphs and feature vectors to it, and use the trained GNN model to predict lncRNA-disease potential association scores. The experimental results show that our method can achieve higher area under the receiver operation characteristic curve (AUC), area under the precision recall curve (AUPR), accuracy and F1-Score than the state-of-the-art methods in five fold cross-validation. Case studies show that our method can effectively identify lncRNAs associated with breast cancer, gastric cancer, prostate cancer, and renal cancer.

Conclusion

The experimental results indicate that our method is a useful approach for predicting potential LDAs.
Hierarchical shared transfer learning for biomedical named entity recognition
Authors: Chai Zhaoying , Jin Han , Shi Shenghui , Zhan Siyan , Zhuo Lin , Yang Yu
Published: January 2022

Background

Biomedical named entity recognition (BioNER) is a basic and important medical information extraction task to extract medical entities with special meaning from medical texts. In recent years, deep learning has become the main research direction of BioNER due to its excellent data-driven context coding ability. However, in BioNER task, deep learning has the problem of poor generalization and instability.

Results

we propose the hierarchical shared transfer learning, which combines multi-task learning and fine-tuning, and realizes the multi-level information fusion between the underlying entity features and the upper data features. We select 14 datasets containing 4 types of entities for training and evaluate the model. The experimental results showed that the F1-scores of the five gold standard datasets BC5CDR-chemical, BC5CDR-disease, BC2GM, BC4CHEMD, NCBI-disease and LINNAEUS were increased by 0.57, 0.90, 0.42, 0.77, 0.98 and − 2.16 compared to the single-task XLNet-CRF model. BC5CDR-chemical, BC5CDR-disease and BC4CHEMD achieved state-of-the-art results.The reasons why LINNAEUS’s multi-task results are lower than single-task results are discussed at the dataset level.

Conclusion

Compared with using multi-task learning and fine-tuning alone, the model has more accurate recognition ability of medical entities, and has higher generalization and stability.
An effective drug-disease associations prediction model based on graphic representation learning over multi-biomolecular network
Authors: Jiang Hanjing , Huang Yabing
Published: January 2022

Background

Drug-disease associations (DDAs) can provide important information for exploring the potential efficacy of drugs. However, up to now, there are still few DDAs verified by experiments. Previous evidence indicates that the combination of information would be conducive to the discovery of new DDAs. How to integrate different biological data sources and identify the most effective drugs for a certain disease based on drug-disease coupled mechanisms is still a challenging problem.

Results

In this paper, we proposed a novel computation model for DDA predictions based on graph representation learning over multi-biomolecular network (GRLMN). More specifically, we firstly constructed a large-scale molecular association network (MAN) by integrating the associations among drugs, diseases, proteins, miRNAs, and lncRNAs. Then, a graph embedding model was used to learn vector representations for all drugs and diseases in MAN. Finally, the combined features were fed to a random forest (RF) model to predict new DDAs. The proposed model was evaluated on the SCMFDD-S data set using five-fold cross-validation. Experiment results showed that GRLMN model was very accurate with the area under the ROC curve (AUC) of 87.9%, which outperformed all previous works in terms of both accuracy and AUC in benchmark dataset. To further verify the high performance of GRLMN, we carried out two case studies for two common diseases. As a result, in the ranking of drugs that were predicted to be related to certain diseases (such as kidney disease and fever), 15 of the top 20 drugs have been experimentally confirmed.

Conclusions

The experimental results show that our model has good performance in the prediction of DDA. GRLMN is an effective prioritization tool for screening the reliable DDAs for follow-up studies concerning their participation in drug reposition.
An ontogenic study of receptor mechanisms by which acute administration of low-doses of methamphetamine suppresses DOI-induced 5-HT2A-receptor mediated head-twitch response in mice
Authors: Sun Yina , Chebolu Seetha , Henry Denise , Lankireddy Sandeep , Darmani Nissar A.
Published: January 2022

Background

Methamphetamine (MA) is a non-selective monoamine releaser and thus releases serotonin (5-HT), norepinephrine (NE) and dopamine (DA) from corresponding nerve terminals into synapses. DOI ((±)-2, 5-dimethoxy-4-iodoamphetamine) is a direct-acting serotonergic 5-HT2A/C receptor agonist and induces the head-twitch response (HTR) via stimulation of 5-HT2A receptor in mice. While more selective serotonin releasers such as d-fenfluramine evoke the HTR, monoamine reuptake blockers (e.g., cocaine) suppress the DOI-evoked HTR via indirect stimulation of serotonergic 5-HT1A- and adrenergic ɑ2-receptors. Since the induction of HTR by DOI is age-dependent, we investigated whether: (1) during development MA can evoke the HTR by itself, and (2) acute pretreatment with either the selective 5-HT2A receptor antagonist EMD 281014 or low-doses of MA can: (i) modulate the DOI-induced HTR in mice across postnatal days 20, 30 and 60, and (ii) alter the DOI-induced c-fos expression in mice prefrontal cortex (PFC). To further explore the possible modulatory effect of MA on DOI-induced HTR, we investigated whether blockade of inhibitory serotonergic 5-HT1A- or adrenergic ɑ2-receptors by corresponding selective antagonists (WAY 100635 or RS 79948, respectively), can prevent the effect of MA on DOI-induced HTR during aging.

Results

Although neither EMD 281014 nor MA by themselves could evoke the HTR, acute pretreatment with either EMD 281014 (0.01, 0.05 and 0.1 mg/kg, i.p.) or MA (1, 2.5, 5 mg/kg, i.p.), dose-dependently suppressed the DOI-induced HTR across ages. While WAY 100635 significantly reversed the inhibitory effect of MA in 20- and 30-day old mice, RS 79948 failed to significantly counter MA’s inhibitory effect. Moreover, DOI significantly increased c-fos expressions in several PFC regions. EMD 281014 prevented the DOI-induced increases in c-fos expression. Despite the inhibitory effect of MA on DOI-induced HTR, MA alone or in combination with DOI, significantly increased c-fos expression in several regions of the PFC.

Conclusion

The suppressive effect of MA on the DOI-evoked HTR appears to be mainly due to functional interactions between the HTR-inducing 5-HT2A receptor and the inhibitory 5-HT1A receptor. The MA-induced increase in c-fos expression in different PFC regions may be due to MA-evoked increases in synaptic concentrations of 5-HT, NE and/or DA.