bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of an Intimate Partner Violence Against Women Training Program Based on the Theory of Planned Behavior on the Approaches of Nurses and Midwives: A Randomized Controlled Study
Authors: Koştu Nazan , Toraman Aynur Uysal
Published: June 2021

The aim of this study was to analyze the effect of intimate partner violence against women training program based on the theory of planned behavior on nurses’ and midwives’ approaches of violence. A randomized controlled trial was performed at nurses and midwives in Turkey, between December 2016 and August 2017. The participants were separated into an intervention group ( n = 50) and control group ( n = 49). According to the result of study, training given to the intervention group was more effective in increasing the intimate partner violence attitudes, practices, and reporting compared to the control group. These results show that this training program effectively developed the nurses’ and midwives’ approaches about intimate partner violence against women.
Teacher Workplace Bullying: How Pervasive is the Problem?
Authors: Catherine Scheeler Mary , Markelz Andrew , Taylor Jonte C. , Deshpande Divya S. , Wolfe Pamela
Published: June 2021

Bullying in schools is a national problem receiving much needed attention. Teacher workplace bullying is a lesser known but equally debilitating problem. Our purpose in doing this study is to examine the problem of teacher workplace bullying and its effect on teachers, students, and schools. We surveyed 173 general and special education teachers to determine the extent that teachers report workplace bullying by other teachers and administrators. We used the Negative Acts Questionnaire–Revised to examine three constructs of workplace bullying—personal, work-related, and physical intimidation. We also examined differences in self-reported workplace bullying between general and special education teachers. Results suggest special education teachers reported a significantly high level of workplace bullying compared with general education teachers. Unsatisfactory administrative support was the most significant factor contributing to workplace dissatisfaction overall. We offer possible starting points to deal with the problem and discuss implications for teachers, students, and the field.
“How Will You Give Back?”: On Becoming a Compañera as a Feminist Methodology from the Cracks
Authors: Shokooh Valle Firuzeh
Published: June 2021

Issues of power, inequality, and representation in the production of knowledge have a long history in transnational feminist research. And yet the unequal relationship between ethnographers and participants continues to haunt feminist research. Drawing from ethnographic fieldwork with the cooperative Sulá Batsú in Costa Rica between 2015 and 2019, in this essay I argue that centering solidarity and working through discomfort creates relationships that can reinvent and endure the persistent imbalance of power between researcher and participant. I conceptualize a solidarity-based methodology that is uncomfortable, tossing between "us and them," the objective and the subjective, akin to Gloria Anzaldúa’s “nepantla,” a liminal space of both fragmentation and unification, of both anguish and healing: a methodology from the cracks. In this essay, I reflect upon my experiences as a Puerto Rican feminist researcher focusing on Sulá Batsú, specifically on my relationship with the coop’s general coordinator. I conducted ethnographic fieldwork with the coop, including participant observation, in-depth interviews, and textual analysis of their research, briefs, blog posts, presentations, and promotional literature.
Ayurveda Body–Mind Constitutional Types and Role of Yoga Intervention Among Type 2 Diabetes Mellitus Population of Chandigarh and Panchkula Regions
Authors: Sivapuram Madhava Sai , Srivastava Vinod , Kaur Navneet , Anand Akshay , Nagarathna Raghuram , Patil Suchitra , Biman Saranga , Chander Ishwar , Jyoti Saras , Nagendra Hongasandra Ramarao
Published: June 2021

Background:

Type 2 diabetes needs a better understanding of etiological factors and management strategies based on lifestyle and constitutional factors, given its high association rate with many cardiovascular, neurological disorders, and COVID-19 infection.

Purpose:

The present study was undertaken to investigate the effect of Diabetes-specific integrated Yoga lifestyle Protocol (DYP) on glycemic control and lipid profiles of diabetic adults. Along with the DYP intervention, the individuals residing in Chandigarh and Panchkula union territories in the northern part of India were assessed for Ayurveda-based body–mind constitutional type. Ayurveda describes body–mind constitution as “ prakriti,” which has been discussed from two angles, namely physiological and psychological as body and mind are correlated.

Methods:

Cluster sampling of waitlist control study subjects was used as the sampling method for the study. A total of 1,215 registered subjects (81 diabetic) responded in randomly selected clusters in Chandigarh and Panchkula. Ayurveda physicians did Ayurveda body–mind constitutional assessment called prakriti assessment (physiological body–mind constitution assessment) in 35 participants (23 diabetic, 12 prediabetic) as a part of the study.

Results:

A group of 50 subjects was randomly selected for yoga intervention out of 81 diabetes mellitus adults, and 31 subjects were enrolled as waitlist controls. A significant decrease in the glycosylated hemoglobin levels from 8.49 ± 1.94% to 7.97 ± 2.20% in the intervention group was noticed. The lipid profiles of the DYP intervention and control groups were monitored. Three-month follow-up results of lipid profile diagnostic tests in intervention and control groups showed a significant difference between the two groups ( P < 0.05). Most diabetic and prediabetic individuals were found to have pitta dosha ( pitta controls all heat, metabolism, and transformation in the mind and body) as dominant constitution type.

Conclusion:

The study results demonstrated significant positive effects of yoga in diabetic individuals. This study has indicated the evidence for the safety and efficacy of the validated DYP for community-level interventions to prevent maladies like brain damage and stroke.
The study of motor skills under a view of hierarchical organisation of open system
Authors: Corrêa Umberto Cesar , Clavijo Fabian Alberto Romero , Reis Marcos Antônio Mattos dos , Tani Go
Published: June 2021

This article considers human motor skills based on the concept of the hierarchical organisation of living systems. This concept considers apparently opposite phenomena (e.g. consistency-variability) as complementary and as contemplated in the same structure. The hierarchy in open systems is characterised by three main relativities: (a) whole and parts, (b) control and (c) variability. From a hierarchical standpoint, motor skills phenomena are structured under two levels: macro (responsible for the consistency and configuration of patterns) and micro (responsible for variability and, consequently, the flexibility of patterns). Study findings make it possible to understand how adaptations in the soccer, futsal, swimming, golf, coincident timing and graphic motor skills take place by altering the microstructure (parameterisation) or reorganising the macrostructure (self-organisation). The distinction between these two modes of adaptation allows us to consider the increase of complexity in the motor skills phenomena as a basic feature of living systems.
Evaluation of a Weightbearing CT Artificial Intelligence-Based Automatic Measurement for the M1-M2 Intermetatarsal Angle in Hallux Valgus
Authors: Day Jonathan , de Cesar Netto Cesar , Richter Martinus , Mansur Nacime Salomao , Fernando Celine , Deland Jonathan T. , Ellis Scott J. , Lintz François
Published: June 2021

Background:

Weightbearing cone beam computed tomography (WBCT) has been gaining traction as a useful imaging modality in the diagnosis and follow-up of foot and ankle musculoskeletal pathologies due to the ability to perform quick, low-dose, 3-dimensional (3D) scans. However, the resulting wealth of 3D data renders daily clinical use time-consuming. The aim of this study was to evaluate a new artificial intelligence (AI)–based automatic measurement for the M1-M2 intermetatarsal angle (IMA) in hallux valgus (HV). We hypothesized that automatic and manual measurements would have a strong correlation, and that the AI software would yield better reproducibility and would be faster compared with manual measurements.

Methods:

This was a multicenter retrospective comparative case-control study in which a total of 128 feet were included from 93 patients who underwent WBCT scans as part of their routine follow-up: 59 feet with symptomatic HV and 69 controls. The IMA was measured automatically using the AI software and manually on digitally reconstructed radiographs (DRRs). The AI software produced both an automatic 2D (auto 2D) and 3D (auto 3D) measurement.

Results:

There were strong intermethod correlations between the DRR IMA and the auto 2D (HV, r = 0.61; control, r = 0.60; all P < .0001) and auto 3D (HV, r = 0.63; control, r = 0.52; all P < .0001) measurements, respectively. The intrasoftware reproducibility was very close to 100%. Measurements took 23.6 ± 2.31 seconds and 14.5 ± 1.18 seconds, respectively, when taken manually on DRRs and automatically. Controls demonstrated a mean DRR IMA of 8.6 (95% CI, 8.1-9.1), mean auto 2D of 11.2 (95% CI, 10.7-11.7), and mean auto 3D IMA of 11.0 (95% CI, 10.5-11.5). The HV group demonstrated significantly increased IMA compared with controls ( P < .0001), with a mean DRR IMA of 15.4 (95% CI, 14.8-16.1), mean auto 2D of 17.8 (95% CI, 17.2-18.4), and mean auto 3D IMA of 16.8 (95% CI, 16.8-17.4).

Conclusion:

Measurements generated by the WBCT AI-based automatic measurement system for IMA demonstrated strong correlations with manual measurements, with near-perfect reproducibility. Further developments are warranted in order to make this tool more usable in daily practice, particularly with respect to its use in the presence of hardware in the foot.

Level of Evidence:

Level III, retrospective comparative study.
Suture Anchor Augmentation for Acute Unstable Isolated Ankle Syndesmosis Disruption in Athletes
Authors: Kim Jin Su , Shin Hyuck Soo
Published: June 2021

Background:

Isolated ankle syndesmosis disruption (without fibula fracture) causes acute pain and may cause chronic instability and pain. The aim of the present study was to evaluate the outcomes after anterior inferior tibiofibular ligament (AITFL) anatomical fixation using anchor sutures for unstable isolated syndesmosis disruption without fibular fractures.

Methods:

This study assessed 22 athletes who were diagnosed with unstable isolated syndesmosis disruption with a positive external rotation test, had more than 2-mm diastasis on ultrasound, and had complete AITFL rupture on magnetic resonance imaging between 2004 and 2020. Eighteen patients (82%) were elite-level athletes, and the remaining 4 were recreational athletes. Twelve patients (55%) were injured by an external rotation force. The athletes underwent open anatomical suture anchor fixation between the AITFL attachment sites, the fibula and tibia. The mechanism of injury, return-to-play time, and Foot and Ankle Outcome Score (FAOS) were evaluated.

Results:

All athletes returned to previous play except 1 retired elite athlete. Twenty-two athletes returned to jogging, team training, and official game play at an average of 62, 89, and 102 days, respectively. The final average follow-up FAOS symptom, pain, daily activity, sports activity, and quality of life scores were 98, 97, 100, 99, and 97, respectively. Two athletes were reinjured, and 1 required reoperation in the follow-up period.

Conclusion:

Athletes with isolated syndesmosis disruption had a high likelihood to return to their previous activity level after suture anchor augmentation.

Level of Evidence:

Level IV, case series.
Four-Dimensional CT Analysis of Normal Syndesmotic Motion
Authors: Wong Murray T. , Wiens Charmaine , Lamothe Jeremy , Edwards W. Brent , Schneider Prism S.
Published: June 2021

Background:

The syndesmosis ligament complex stabilizes the distal tibiofibular joint while allowing for small amounts of physiologic motion. When injured, malreduction of the syndesmosis is the most important factor that contributes to inferior functional outcomes. Syndesmotic reduction is a dynamic measure, which is not adequately captured by conventional computed tomography (CT). Four-dimensional CT (4DCT) can image joints as they move through range of motion (ROM). The aim of this study was to employ 4DCT to determine in vivo syndesmotic motion with ankle ROM in uninjured ankles.

Methods:

Uninjured ankles were analyzed in patients who had contralateral syndesmotic injuries, as well as a cohort of healthy volunteers with bilateral uninjured ankles. Bilateral ankle 4DCT scans were performed as participants moved their ankles between maximal dorsiflexion and plantarflexion. Multiple measures of syndesmotic width, as well as sagittal translation and fibular rotation, were automatically extracted from 4DCT using a custom program to determine the change in syndesmotic position with ankle ROM.

Results:

Fifty-eight ankles were analyzed. Measures of syndesmotic width decreased by 0.7 to 1.1 mm as the ankle moved from dorsiflexion to plantarflexion ( P < .001 for each measure). The fibula externally rotated by 1.2 degrees with ankle ROM ( P < .001), but there was no significant motion in the sagittal plane ( P = .43). No participants with bilateral uninjured ankles had a side-to-side difference in syndesmotic width of 2 mm or greater.

Conclusion:

4DCT allows accurate, in vivo syndesmotic measurements, which change with ankle ROM, confirming prior work that was limited to biomechanical studies. Side-to-side syndesmotic measurements are consistent within subjects, validating the method of templating syndesmotic reduction off the contralateral ankle, in a consistent ankle position, to achieve anatomic reduction of syndesmotic injury.

Level of Evidence:

Level II, prospective cohort study.
Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective
Authors: Su Li-Da , Wang Na , Han Junhai , Shen Ying
Published: June 2021

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated in multiple CNS disorders, such as Alzheimer’s disease, autism, Parkinson’s disease, and so on. In the present review, we systematically discussed underlying mechanisms and prospective of Gp1 mGluRs in a group of neurological and psychiatric diseases, including Alzheimer’s disease, Parkinson’s disease, autism spectrum disorder, epilepsy, Huntington’s disease, intellectual disability, Down’s syndrome, Rett syndrome, attention-deficit hyperactivity disorder, addiction, anxiety, nociception, schizophrenia, and depression, in order to provide more insights into the therapeutic potential of Gp1 mGluRs.
Treatment Satisfaction in a Civil Commitment Facility for Sexually Violent Persons
Authors: Vincent Samuel , Kahn Rachel E. , Ambroziak Gina , Smith Jason , Jardas EJ
Published: June 2021

Evaluating patient satisfaction in therapeutic settings is consistent with a Risk–Needs–Responsivity (RNR) model. This study provides results from a program improvement initiative in a sexually violent person (SVP) civil commitment facility that queried patients and treatment providers about their satisfaction with therapeutic processes and assessment methods. Overall, patients reported high levels of satisfaction with treatment at the facility, with the highest levels of satisfaction on items about being treated with kindness and respect and staff acting professionally. Providers rated current assessment methods such as the Penile Plethysmography (PPG) assessment, polygraph testing, and neuropsychological testing as most helpful for patients in treatment progress; however, patients rated PPG assessment and polygraph testing as the least helpful of the assessments conducted. Soliciting patient feedback periodically could be important for maintaining treatment engagement and discovering opportunities to enhance patient satisfaction to treatment in a SVP civil commitment setting.
Safety and effectiveness of subcutaneously anchored securement for tunneled central catheters in oncological pediatric patients: A retrospective study
Authors: Crocoli Alessandro , Martucci Cristina , Sidro Luca , Delle Donne Daniela , Menna Giuseppe , Pittiruti Mauro , De Pasquale Maria Debora , Strocchio Luisa , Natali Gian Luigi , Inserra Alessandro
Published: June 2021

Background:

Proper securement of central venous catheters plays an important role in onco-hematological pediatric patients. A new subcutaneously anchored securement device has been recently introduced in the clinical practice, and it has been extensively used in children.

Method:

In our study, we have retrospectively investigated the safety and the effectiveness of such device, reviewing the experience of three Italian pediatric oncological units. We have considered only tunneled catheters (cuffed or non-cuffed) inserted in children with malignancy; all types of tunneled central catheters were included in the analysis (both centrally and peripherally inserted) as long as they were secured with a subcutaneously anchored device. We investigated the incidence of dislodgment and of other catheter-related complications, with special attention to local adverse effects potentially related to the securement device.

Results:

We collected data from 311 tunneled catheters of different caliber: 80.4% were centrally inserted central catheters (CICC), 15.4% were peripherally inserted (PICC), and 4.2% were femorally inserted. Approximately half of the catheters (51%) were non-cuffed. Incidence of dislodgment was very low (2.6%) and the incidence of local pain or inflammation potentially related to the securement device was minimal (1.9%). Catheter related bacteremias were below 1 episode/1000 catheter days. No symptomatic catheter related thrombosis was reported. There was no significant difference in complications comparing cuffed versus non-cuffed catheters, or CICCs versus PICCs, or hematologic tumors versus solid tumors.

Conclusion:

In our retrospective analysis of a vast population of oncological pediatric patients with tunneled central catheters, the subcutaneously anchored securement device was tolerated very well, and it was highly effective in preventing dislodgment, both in cuffed and non-cuffed catheters.
A new consultation, Assessment and reflection model (CARM) used in child and adolescence mental health services (CAMHS)
Authors: Mansell Louise , Hughes Kirsty , Heyes Jane-Ward , Brownlee Adrian , Charm Clare , Blake Daniel , Collinge Sarah , Smith Jason
Published: June 2021

UK National Guidelines stress the importance of reducing waiting times for mental health assessments and interventions for children. They stress the importance of early help, multidisciplinary working, and collaboration with families regarding treatment plans. We piloted a new assessment model (CARM) within a CAMHS service to: reduce non-attendance rates and subsequently waiting times; increase staff and patient satisfaction; and improve the quality of assessment. All waiting list patients and new referrals over a three-month period were contacted to self-book an hour session to meet two clinicians who utilised collaborative reflection and formulation to produce a care plan (CARM). Results revealed that non-attendance rates dropped from 33% over the month prior to CARM to 7% during CARM. Satisfaction levels were high. Qualitative feedback regarding satisfaction revealed the most common themes was feeling listened to and having the opportunity to listen to staff reflections. The themes of staff satisfaction included ‘feeling more supported’ and ‘feeling safer in their decision making’. All assessments were completed in the one appointment. A formulation-driven care plan was developed and discussed with the family. This approach has the potential to make services more effective, efficient and satisfying for both staff and families.
How bilinguals refer to Mandarin throwing actions in English
Authors: Nicoladis Elena , Gao Helena Hong
Published: June 2021

Aims and Objectives:

In the present study, we tested how Mandarin-English bilinguals choose English words to refer to prototypical Mandarin throwing actions. Languages differ in how they refer to events. In Mandarin and English, words for throwing actions differ notably on a variety of dimensions so there are few perfect translation equivalents. In previous studies, when faced with the challenge of how to speak about such events, bilinguals sometimes use language-specific ways in each language, sometimes show convergence, sometimes use more general terms, and there are times when they can be quite creative.

Design/Methodology:

We showed video clips of six prototypical Mandarin throwing actions (corresponding to rēng 扔, diū 丢, pāo 抛, tóu 投, shuāi 摔, shuǎi 甩) to Mandarin-English bilinguals and English monolinguals. Participants labeled the actions and chose the English word most closely corresponding to the action. The bilinguals did the same in Mandarin.

Findings/Conclusion:

The results showed that the bilinguals chose many of the same words in English as English monolinguals did. However, the bilinguals differed from the monolinguals in two ways: (1) they tended to choose more different responses and (2) they referred to diū 丢 actions most often as throw rather than lob as the monolinguals did.

Originality:

These results suggest that bilinguals use a variety of strategies to refer to the not-easily-translatable.
Navigating the maze: Deepfakes, cognitive ability, and social media news skepticism
Authors: Ahmed Saifuddin
Published: June 2021

The early apprehensions about how deepfakes (also deep fakes) could be weaponized for social and political purposes are now coming to pass. This study is one of the first to examine the social impact of deepfakes. Using an online survey sample in the United States, this study investigates the relationship between citizen concerns regarding deepfakes, exposure to deepfakes, inadvertent sharing of deepfakes, the cognitive ability of individuals, and social media news skepticism. Results suggest that deepfakes exposure and concerns are positively related to social media news skepticism. In contrast, those who frequently rely on social media as a news platform are less skeptical. Higher cognitive abled individuals are more skeptical of news on social media. The moderation findings suggest that among those who are more concerned about deepfakes, inadvertently sharing a deepfake is associated with heightened skepticism. However, these patterns are more pronounced among low than high cognitive individuals.
How source-level and message-level factors influence journalists’ social media visibility during a public health crisis
Authors: Zhang Xinzhi , Zhu Rui
Published: June 2021

Social media has become a channel through which journalists distribute their work, reach audiences and gain visibility. Informed by the frameworks of journalistic branding, the heuristic-systematic model, and hypertextual elements, the present study examines the extent to which the source factor (journalists’ branding on social media profiles) and message factors (communication styles and hypertextual elements) influence visibility (i.e. the popularity of the account and the number of favourites and retweets of the posts). We analysed the Twitter profiles of 98 health journalists from seven major media organizations in the US and conducted a manual content analysis of a representative sample of their public tweets (n = 3982) published during the Covid-19 pandemic. In contrast to expectations, branding contributed little to any indicators of visibility, and profiles with institutional branding had fewer followers. Both affective messages and rational messages received more likes and retweets than messages without these elements. Tweets containing images or news-related hyperlinks received more retweets, whereas the number of @mentions in a tweet was negatively related to visibility. Journalists from traditional media, those who tweeted more often, and those with more followers had higher levels of visibility.
Between field and home: notes from the balcony
Authors: Ragavan Shruti
Published: June 2021

Balconies, windows and terraces have come to be identified as spaces with newfound meaning over the past year due to the Covid-19 pandemic and concomitant lockdowns. There was not only a marked increase in the use of these spaces, but more importantly a difference in the very nature of this use since March 2020. It is keeping this latter point in mind, that I make an attempt to understand the spatial mobilities afforded by the balcony in the area of ethnographic research. The street overlooking my balcony, situated amidst an urban village in the city of Delhi – one of my field sites, is composed of middle and lower-middle class residents, dairy farms and farmers, bovines and other nonhumans. In this note, through ethnographic observations, I reflect upon the balcony as constituting that liminal space between ‘field’ and ‘home’, as well as, as a spatial framing device which conditions and affects our observations and interactions. This is explored by examining two elements – the gendered nature of the space, and the notion of ‘distance and proximity’, through personal narratives of engaging-with the field, and subjects-objects of study in the city.
Regulatory voids in the prevention of environmental crime in Finland
Authors: Sahramäki Iina P , Kankaanranta Terhi T
Published: June 2021

Increasing concern about environmental issues has heightened the need for the effective enforcement of environmental regulations and for research supporting these efforts. This study incorporates intersectoral analysis and examines regulatory voids. The aim is to analyse whether regulatory voids exist and how they affect the enforcement efforts related to the prevention, supervision and detection of illicit waste activities and, furthermore, waste crime in Finland. The Delphi method is used to analyse different aspects of regulatory voids in enforcement and crime prevention. The three-round Delphi comprised a panel of 74 participants from different sectors and had a significantly high response rate: 91 percent in the first round, 82 percent in the second and 80 percent in the third, respectively. Not only do the findings indicate that political, institutional and knowledge-regulatory voids exist, the study also suggests that the knowledge void should be further divided into informational and professional void – and, as such, there are actually four regulatory voids to be found that should be analysed. Findings also suggest that there is lack of consensus on regulatory enforcement, severe challenges in the flow of information and insufficient resources, which together form a contradictory regulatory regime based on trust between regulators and regulatees, on the one hand, and underlying assumptions of foul play, on the other. The study concludes that enforcement authorities walk a regulatory tightrope between compliance with and punishment of regulatory strategies, trying during the course of their work to avoid falling into the regulatory voids.
Positive and Negative Impacts of the COVID-19 Pandemic on Relationship Satisfaction in Male Couples
Authors: Walsh Alison R. , Stephenson Rob
Published: June 2021

Little is known about the impact of the coronavirus pandemic and control measures on gay, bisexual, and other men who have sex with men (GBMSM) couples. The goal of this study was to investigate individual-level relationship satisfaction during the COVID-19 pandemic in a sample of 209 coupled GBMSM in the United States. We analyzed reported happiness and feelings about a relationship’s future and assessed the odds of changing relationship happiness and investment associated with pandemic-related life changes (pandemic-related employment change; COVID-19 illness; high-risk of severe illness), using logistic and multinomial logit models. Fifty-five percent of participants ( N = 114) reported that their relationship happiness had not changed during the pandemic, but 30% ( N = 62) reported increased relationship happiness. 25% ( N = 53) reported they had become more invested in their relationship’s future during the pandemic, and only one participant reported decreased investment. The odds of increased relationship investment was significantly associated with pandemic-related employment change (adjusted odds ratio (aOR), 95% confidence interval (CI): 2.19 [1.04, 4.61]) and increased sex during the pandemic (aOR: 4.38 [1.55, 12.41]). Those with a pandemic-related employment change also had significantly higher odds of increased relationship happiness than those without a change (aOR: 2.10 [1.01, 4.35]). COVID-19 cases that reported being at higher risk of serious COVID-19 disease had higher odds of decreased relationship happiness than high-risk non-cases (aOR: 6.58 [1.10, 39.39]). Additional research in this area is warranted to minimize the long-term impacts of the pandemic on coupled GBMSM.
Clinical Outcomes After Aggressive Active Early Motion and Modified Kleinert Regimens: Comparison of 2 Consecutive Cohorts
Authors: Jokinen Kaisa , Häkkinen Arja , Luokkala Toni , Karjalainen Teemu
Published: June 2021

Background

Modern multistrand repairs can withstand forces present in active flexion exercises, and this may improve the outcomes of flexor tendon repairs. We developed a simple home-based exercise regimen with free wrist and intrinsic minus splint aimed at facilitating the gliding of the flexor tendons and compared the outcomes with the modified Kleinert regimen used previously in the same institution.

Methods

We searched the hospital database to identify flexor tendon repair performed before and after the new regimen was implemented and invited all patients to participate. The primary outcome was total active range of motion, and secondary outcomes were Disabilities of Arm, Shoulder, and Hand; grip strength; globally perceived function; and the quality of life.

Results

The active range of motion was comparable between the groups (mean difference = 14; 95% confidence interval [CI], −8 to 36; P = .22). Disabilities of Arm, Shoulder, and Hand; grip strength; global perceived function; and health-related quality of life were also comparable between the groups. There was 1 (5.3%) rupture in the modified Kleinert group and 4 (15.4%) in the early active motion group (relative risk = 0.3; 95% CI, 0.04-2.5; P = .3).

Conclusions

Increasing active gliding with a free wrist and intrinsic minus splint did not improve the clinical outcomes after flexor tendon injury at a mean of 38-month follow-up.
When is surgical resection alone appropriate treatment for pediatric nodular lymphocyte-predominant Hodgkin lymphoma?
Authors: Bessen Sarah Y , Gardner Juli-Anne , Chen Eunice Y
Published: June 2021

The surgeon’s role in the management of lymphoma is typically limited to performing biopsies for diagnosis. Most patients with lymphoma are treated with chemotherapy and/or radiation, but in rare cases, lymphoma can be primarily treated with surgery. We present a case of nodular lymphocyte-predominant Hodgkin lymphoma in a 4-year-old child with cervical adenopathy and discuss initial treatment with surgery alone. Surgery as primary treatment avoids the serious long-term sequelae of chemotherapy and radiation, and reserves those options for possible future recurrences; however, this approach should be reserved for patients with limited and low-risk disease. This case report reviews the pros and cons of treating early-stage nodular lymphocyte-predominant Hodgkin lymphoma in a pediatric patient with surgery alone.
Intraabdominal lesser sac metastasis from Ewing’s sarcoma: An exceptional localization
Authors: Bouhani Malek , Sassi Imen , Zemni Ines , Sahraoui Ghada , Bouida Amine , Slimene Maher , Rahal Khaled
Published: June 2021

Ewing’s sarcoma/primitive neuroectodermal tumor is rare and aggressive with a poor prognosis. Intraabdominal metastases are an uncommon condition. Metastasis in the lesser sac is an exceptional occurrence. To the best of our knowledge, this location has not been described previously. We report a case of a 15-year-old patient treated for Ewing’s sarcoma of the left arm 6 years back. She had developed a suspicious mass in the lesser sac 6 years following her primary tumor. The histopathologic exam revealed a tumor with “small round cells” that were positive for CD99, confirming the relapse of Ewing’s sarcoma. The relapse was successfully managed with chemotherapy and surgery. Intraabdominal, extraintestinal masses in patients treated previously for Ewing’s sarcoma should be considered as Ewing’s sarcoma relapse in the differential diagnosis. We fully describe the management of this atypical relapse, with different components of clinical, radiological, and histological findings.
What Are The Channels Through Which Bank Liquidity Creation Affects GDP? Evidence From an Emerging Country
Authors: Umar Muhammad , Sial Muhammad Safdar , Xu Yan
Published: June 2021

Gross domestic product (GDP) depends on myriad factor and financial intermediaries especially banks play a very important role in economic growth and development of a country. They not only lend loans rather also generate liquidity—which is very important for the smooth functioning of an economy. Therefore, this study explores the channels through which bank liquidity creation affects GDP. It uses the data from listed and unlisted Chinese banks ranging from the year 2006 to 2017. The results of the analysis reveal that the liquidity creation by Chinese banks significantly negatively affects economic output. The magnitude of the impact of small-bank liquidity creation is greater than the large banks. Variation in the GDP is explained by current and previous year’s liquidity creation. Cat-fat measure of liquidity creation affects GDP directly as well as through consumption, investment, government expenditure, and net exports channels; however, cat-nonfat measure affects economic output directly and through all aforementioned channels except net exports. Overall, the findings support the hypothesis that liquidity creation affects the economy directly as well as through different channels.
COVID-19 and Combined Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Nonketotic Coma: Report of 11 Cases
Authors: Singh Balraj , Kaur Parminder , Majachani Nicole , Patel Prem , Reid Ro-Jay Romor , Maroules Michael
Published: June 2021

We report 11 cases of combined diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar nonketotic coma (HHNK) in coronavirus 2019 patients who presented to our institution in New Jersey, USA. The median age was 47 years (range 12-88 years). Out of the 11 patients, 7 were male and 4 were female. Out of 11 patients, 8 had type 2 diabetes mellitus (DM), 2 had undiagnosed DM, and 1 had type 1 DM. Presenting complaints included altered mental status, weakness, shortness of breath, cough, fever, vomiting, abdominal pain, chest pain, and foot pain. Out of 11 patients, pneumonia was diagnosed at presentation in 8 patients, while in 3 patients, chest X-ray was clear. Median value of initial glucose on presentation was 974 mg/dL (range 549-1556 mg/dL), and hemoglobin A1c on presentation was 13.8%. The median value of anion gap was 34 mEq/L. Out of the 11 patients, ketonemia was moderate in 6 patients, large in 3, and small in 2 patients. Acute kidney injury (AKI) occurred in 9 patients and 2 patients required renal replacement therapy. Out of the 11 patients, 6 required mechanical ventilation and 7 patients died. All the 6 patients requiring mechanical ventilation died. Our case series shows COVID-19 infection can precipitate acute metabolic complications in known DM patients or as first manifestation in undiagnosed DM patients. Patients can present with DKA/HHNK symptoms and/or respiratory symptoms. Mechanical ventilation is a poor prognostic factor. Further studies are needed to characterize prognostic factors associated with mortality in this vulnerable patient population.
How Are ‘Included’ Excluded and Vice-Versa: Negotiated Participation of Women in School Governance in Nepal
Authors: Dhakal Rebat Kumar
Published: June 2021

Women representation in public institutions has been a key policy shift in Nepal in the recent decade. Despite such policy intervention as affirmative action measures to encourage women participation in public institutions and likewise increased presence of women in politics and public institutions, women’s participation at local level school decision-making processes remains limited. Through a lens of representation and theory of participation and an examination of women’s experiences, this study critically examines the dynamics of inclusion and exclusion in the School Management Committee. Drawing on original ethnographic research in a secondary school in rural Kaski, Gandaki Province, Nepal, this study draws that predominant female gender images were reproduced in the initial stage of women participation which made them feel ‘othered’ and ‘excluded’; however, gradually, with the passage of time and learning, such images receded and they felt more ‘included’ and were thereby likely to demonstrate more substantive participation.
Social Media and Video Conferencing Platforms for Group Therapy and Community Mental Health Outreach for LGBTQIA+ Individuals— The SAAHAS Experience
Authors: Wandrekar Jagruti R. , Nigudkar Advaita S.
Published: June 2021

E-health and telehealth are rapidly evolving areas of intervention that may show high potential for use with LGBTQIA+ individuals. Research on the therapeutic utility of these with respect to mental health is limited, particularly in India. SAAHAS (Sexuality, Acceptance, Awareness, Health, and Support) is a queer-affirmative, cognitive behavior therapy-based group therapy model of intervention for LGBTQIA+ individuals. We describe here our facilitator experience with expanding the offline group therapy model to online platforms using Google Meet, with an analysis of attendance and modalities of engagement and a description of our therapy notes and themes of discussion. We describe facilitator experience of continued therapeutic support through WhatsApp by analyzing the chats and thematic coding of the same. We also describe here our attempt at using social media for community mental health outreach through dissemination of mental health messages on Instagram and Facebook; data was analyzed using engagement metrics. Observations of the utility and limitations of these video conferencing and social media platforms and suggestions for effective use are provided.
Comparison of Marital and Sexual Functioning of the Spouses of Patients with Schizophrenia and Depressive Disorders
Authors: Aggarwal Shivali , Grover Sandeep , Chakrabarti Subho
Published: June 2021

Aim:

This study assessed the various aspects of marital functioning among the spouses of patients with schizophrenia and recurrent depressive disorder (RDD).

Methodology:

Spouses were assessed on Dyadic Adjustment Scale (DAS), Marital Forgiveness Scale, Quality Marriage Index, New Sexual Satisfaction Scale, and Arizona Sexual Experience Questionnaire.

Results:

Compared to the spouses of patients with RDD, spouses of patients with schizophrenia reported poor marital adjustment (in the consensus and satisfaction domains of DAS), lower quality of marriage, and significantly lower sexual satisfaction. Spouses did not differ significantly on account of marital forgiveness and prevalence of sexual dysfunction. Higher age of onset of schizophrenia in the patients was associated with better quality of marriage as assessed by using quality of marriage scale, better consensus, and satisfaction as per the DAS. Higher residual psychopathology and poor socio-occupational functioning in patients with schizophrenia were associated with poor marital adjustment and sexual satisfaction.

Conclusion:

To conclude, the present study depicts that the spouses of patients with schizophrenia have poorer marital adjustment and sexual satisfaction, in comparison to the spouses of patients with RDD.
Bone marrow aspirate concentrate/platelet-rich fibrin augmentation accelerates healing of aseptic upper limb nonunions
Authors: Mazzotta Alessandro , Stagni Cesare , Rocchi Martina , Rani Nicola , Del Piccolo Nicolandrea , Filardo Giuseppe , Dallari Dante
Published: June 2021

Introduction

Nonunions remain a significant burden in orthopedics, often afflicting young males of working age. Positive findings have been published using bone marrow aspirate concentrate (BMAC) and platelet-rich fibrin (PRF) for the treatment augmentation of lower limb nonunions. The aim of this study was to investigate if the treatment augmentation with BMAC and PRF can also accelerate the healing of nonunions of the upper limb.

Materials and methods

Sixty-eight patients (45 men, 23 women) affected by 75 nonunions of long bones of the upper limb were treated and divided into two groups. The first series was treated with standard surgery alone (group A); afterwards, the second series benefited from standard surgery with the addition of BMAC and PRF applied on lyophilized bone chips. Nonunions were classified radiographically according to the Weber–Cech method and prognostically using the Calori and Moghaddam scores. All patients were radiographically assessed at 1.5, 3, 6, 12, and 24 months of follow-up.

Results

Baseline demographic characteristics did not present differences between groups. No differences were documented in terms of complications (two in group A and three in group B). Significant differences were instead documented in terms of healing time. The first healing signs were observed 1.5 months after surgery in 90.7% of patients in group B and 34.4% of group A (p < 0.0005). At 1.5, 3, 6, and 12 months, a higher radiographic score was found for group B (all p < 0.0005), while no difference was found at final follow-up of 24 months (90.6% of group A and 97.7% of group B achieved radiological healing). Faster healing with BMAC/PRF augmentation was confirmed for all bones, as well as for the subgroup of patients affected by atrophic nonunions (p = 0.001).

Conclusion

This study showed the benefits of restoring both mechanical and biological aspects when addressing nonunions of the long bones of the upper limb. In particular, the association of BMAC and PRF to lyophilized bone chips was safe and able to accelerate healing time. These good results were confirmed for humerus, radius, and ulna sites, as well as for challenging atrophic nonunions of the upper limb.
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A
Authors: Lian Yanfen , Jiang Dongxiao , Sun Jiangtao
Published: June 2021

Background

The suppressive effects of miR-33a-5p have been reported in colorectal cancer and lung cancer. However, the functional role of miR-33a-5p in pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

Methods

The expression of miR-33a-5p was determined using reverse-transcription quantitative PCR (RT-qPCR) in PDAC tissues and cell lines. The association between miR-33a-5p expression and clinical categorical parameters was analyzed by the chi-square test. Cell proliferation was analyzing by Cell Counting Kit -8 (CCK-8) assay. Transwell assay was utilized to assess cell migration and invasion. The interactions between miR-33a-5p and RAP2A were verified by luciferase reporter assay, RT-qPCR, western blot analysis and RNA immunoprecipitation (RIP) assay.

Results

Here, we observed for the first time that miR-33a-5p expression level was significantly decreased in PDAC tissues and cell lines. There was a significant association between decreased miR-33a-5p expression and TNM stage or lymph node metastasis. Overexpression of miR-33a-5p significantly inhibited SW1990 and PANC-1 cell proliferation, migration and invasion. Knockdown of miR-33a-5p remarkedly promoted cell proliferation, migration and invasion in BxPC-3 and ASPC-1. Mechanistically, RAP2A was confirmed as the target of miR-33a-5p in PDAC cells. Moreover, RAP2A overexpression abolished miR-33a-5p-mediated suppressive effects on SW1990 and PANC-1 cells.

Conclusions

Taken together, these results suggest that miR-33a-5p exerted tumor suppressive effects on PDAC cells by targeting RAP2A, which might provide a new theoretical basis for the clinical treatment of PDAC.
Overcoming uncollapsed haplotypes in long-read assemblies of non-model organisms
Authors: Guiglielmoni Nadège , Houtain Antoine , Derzelle Alessandro , Van Doninck Karine , Flot Jean-François
Published: June 2021

Background

Long-read sequencing is revolutionizing genome assembly: as PacBio and Nanopore technologies become more accessible in technicity and in cost, long-read assemblers flourish and are starting to deliver chromosome-level assemblies. However, these long reads are usually error-prone, making the generation of a haploid reference out of a diploid genome a difficult enterprise. Failure to properly collapse haplotypes results in fragmented and structurally incorrect assemblies and wreaks havoc on orthology inference pipelines, yet this serious issue is rarely acknowledged and dealt with in genomic projects, and an independent, comparative benchmark of the capacity of assemblers and post-processing tools to properly collapse or purge haplotypes is still lacking.

Results

We tested different assembly strategies on the genome of the rotifer Adineta vaga, a non-model organism for which high coverages of both PacBio and Nanopore reads were available. The assemblers we tested (Canu, Flye, NextDenovo, Ra, Raven, Shasta and wtdbg2) exhibited strikingly different behaviors when dealing with highly heterozygous regions, resulting in variable amounts of uncollapsed haplotypes. Filtering reads generally improved haploid assemblies, and we also benchmarked three post-processing tools aimed at detecting and purging uncollapsed haplotypes in long-read assemblies: HaploMerger2, purge_haplotigs and purge_dups.

Conclusions

We provide a thorough evaluation of popular assemblers on a non-model eukaryote genome with variable levels of heterozygosity. Our study highlights several strategies using pre and post-processing approaches to generate haploid assemblies with high continuity and completeness. This benchmark will help users to improve haploid assemblies of non-model organisms, and evaluate the quality of their own assemblies.