bluuebunny/crossref_metadata_2025 huggingface dataset:
Kanssatutkimus
Authors: Bettin Katerina , Eriksson Päivi , Ervasti Kaijus , Hakala Katariina , Hietala Outi , Honkatukia Päivi , Hoppania Hanna-Kaisa , Laiho Marjukka , Mietola Reetta , Raittila-Salo Saana , Rättilä Tiina , Sotkasiira Tiina , Tokola Nina , Turja Mari , Vainio Iiris
Published: August 2023

Ihmisten yhdenvertaisuuden esteitä tutkitaan yhä useammin osallistavin menetelmin ja kanssatutkimuksen keinoin. Kanssatutkimuksessa tutkimukseen osallistuviin ihmisiin suhtaudutaan oman elämänsä asiantuntijoina ja tasavertaisina tutkimuskumppaneina. Tällöin tutkimuksen lähtökohtana ovat ihmisten itse määrittämät tutkimusongelmat, tutkimusprosessille asetetut toiveet ja kaikkien osapuolten intressit huomioon ottava aktiivinen kumppanuus. Osallistumista tukevia menetelmiä hyödynnetään kanssatutkimuksessa erityisesti rakenteellisesti haavoittuvassa tai alisteisessa asemassa olevia ryhmiä koskevan tutkimustiedon syvemmäksi kontekstualisoimiseksi ja perinteisiin tutkimusasetelmiin liittyvien valtapositioiden horjuttamiseksi.
Kanssatutkimuksessa tutkimukseen osallistuvien ihmisten rooli on keskeisempi kuin perinteisemmässä tutkimuksessa. Kanssatutkimuksen yksi keskeisimmistä periaatteista on se, että kanssatutkijoilla a) voi olla erilaisia rooleja, b) heillä on mahdollisuus osallistua tutkimuksen eri vaiheisiin oman kiinnostuksensa ja resurssiensa mukaan ja c) kanssatutkijoiden osallistuminen voi olla monenlaista, eroja on muun muassa osallistumisen intensiteetissä. Ajatuksena on tarjota yhä useammille ihmisille mahdollisuuksia osallistua heitä itseään ja yhteisöjään koskevan tiedon tuottamiseen omista lähtökohdistaan käsin. Kanssatutkimus nähdään myös mahdollisuutena parantaa tutkimustiedon tarkoituksenmukaisuutta ja hyödynnettävyyttä. Kanssatutkimuksen tarkoituksena on aidosti lisätä vuorovaikutusta ja avoimuutta sekä laajentaa tieteen yhteiskuntavastuuta.
PERSPECTIVES ON METASTASIS AND SNAKE VENOMS
Authors: Gutiérrez-Pajares Jorge , Gómez-Bentancur Isabel
Published: August 2023

Metastasis is the major responsible for the death of cancer patients. This malignant feature implies the acquisition of protein machineries that allow cells to migrate, modify the extracellular matrix and form new blood vessels.

Since the discovery of disintegrins as ligands and blockers of integrins, many studies have demonstrated that snake venoms are a source of bioactive molecules with anti-metastatic effect. In this review, snake venom molecules are described as inhibitors of metastasis at different levels, pointing to a need for further research.
RELACIÓN ESTRUCTURA–FUNCIÓN DE LAS PROTEÍNAS. USO DE LA TÉCNICA DE ELECTROFORESIS EN EL ESTUDIO DE SU EXPRESIÓN
Authors: Fuchs Delgado Morela
Published: August 2023

Las proteínas son componentes del metabolismo celular presentes en todos los organismos vivos, donde realizan importantes funciones que están relacionadas con su estructura.  Estos compuestos han sido estudiados mediante diferentes técnicas y métodos, pero en los últimos años con el uso de nuevas técnicas, se ha ido cambiando el paradigma sobre estructura-función. En este estudio se realizó un análisis de los nuevos conocimientos sobre la estructura de las proteínas: los plegamientos, motivos y dominios que explican parte de la funcionalidad, las proteínas intrínsicamente desordenadas, también llamadas PINEs o PIDs y las proteínas multifuncionales o Moonlighting, un concepto más flexible en el cual la estructura se adapta a las funciones que realiza. Se revisó el aporte de las nuevas técnicas bioinformáticas en el análisis y organización de una gran cantidad de información que se va produciendo con el estudio de la estructura, mediante cristalografía de rayos X y resonancia magnética nuclear (RMN). También, se analizó el estudio de la expresión de las proteínas a través de la técnica de electroforesis, que continúa siendo una herramienta valiosa y complementaria, para comprender el efecto de los factores ambientales sobre el desarrollo de los organismos.
IMPLEMENTASI PENGELOLAAN DANA BPJS BERDASARKAN PERMENKES NO 28 TAHUN 2014 DI PUSKESMAS KABILA KABUPATEN
Authors: Potutu Alvin , Abdullah Julie , Hasan Wahyudin
Published: August 2023

Penelitian ini bertujuan untuk mengetahui implementasi pengelolaan Dana BPJS di Puskesmas Kabila Kabupaten Bone Bolango. Penelitian ini menggunakan jenis kualitatif deskriptif, teknik pengumpulan data dengan metode wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa Implementasi pengelolaan dana BPJS yaitu dana kapitasi melalui proses perencanaan Dan terdapat kendala, adanya proses pemotongan dana yang tersisa di bulan kemarin.
KARAKTERISTIK HUKUM ISLAM DALAM PERSPEKTIF AJARAN AGAMA ISLAM
Authors: Rozi Ahmad Fahrur
Published: August 2023

Abstrak

Islam adalah agama paripurna, kesempurnaannya itu mengatur semua aspek lini kehidupan baik yang mahdoh maupun yang ghoriu mahdoh. Kaitannya dengan hal tersebut dalam kajian hukum Islam dikenal dengan aspek fiqh, karakteristik dimensi fiqh ini mempunyai kekhasan tersendiri dibandingkan dengan aspek hukum lainnya yang ada. Hal tersebut terjadinya tidak lain dikarenakan sumber maupun dasar penetapannya berasal dari syariat Islam yang bersumber pada Allah SWT dan Rasul-nya. Oleh karena itu dimensi karakteristiknya mempunyai kekhasan tersendiri dibandingkan dengan yang lain, ditambah lagi ada aspek Hikmatus Tasyrik / hikmah dibalik penetapan sebuah hukum yang terkandung dalam tiap hukumnya. Kajian yang digunakan penelitian ini menggunakan penelitian normatif / library research, sumber data yang digunakan lebih menekankan pada sumber data sekunder.

Kata kunci: Karakteristik, Hukum, Fiqh, Syariat.
INFLUENCE OF EMPLOYEE WORK DISCIPLINE ON COMMUNITY SATISFACTION AT THE LENGKONG VILLAGE OFFICE, BOJONGSOANG DISTRICT, BANDUNG REGENCY
Authors: Nuryan Krisna , Rafiyandi Muhammad Daffa , Rahim Ena
Published: August 2023

This study aims to investigate the impact of Employee Work Discipline and Public Service Quality on Community Satisfaction at the Lengkong Village Hall Office, Bojongsoang District, Bandung Regency. A survey method with a quantitative approach was used, and 15 residents who used village office services were selected as respondents. Data were collected through questionnaires to evaluate public perceptions of employee discipline and the quality of public services. The results of the analysis show that employee work discipline has a positive and significant influence on community satisfaction. Employees who uphold discipline are able to provide better and professional service. In addition, the quality of public services also has a positive and significant influence on community satisfaction. Friendly, responsive, efficient, and accurate service increases community satisfaction. However, this study also identified several problems in the quality of public services that need to be addressed to increase public satisfaction. It is hoped that this article can help readers understand and explore information about how important the influence of work discipline and the quality of public services on public satisfaction.
IMPACT ANALYSIS OF TRANSFORMATIONAL LEADERSHIP ON EMPLOYEE PERFORMANCE
Authors: Ningrum Shinta Widia , Amalia Dilla , Supriatna Ecep
Published: August 2023

This study aims to analyze the influence of transformational leadership on the performance of public employees in a government agency. The survey method is used to collect data from employees who are the research subjects. Statistical analysis, including regression, was used to identify the relationship between transformational leadership and employee performance. The results of the research show that there is a positive and significant influence between transformational leadership and the performance of public employees. Employees who experience transformational leadership tend to show higher levels of performance, including achievement of work targets, initiative, collaboration, and better job satisfaction. This research indicates the importance of transformational leadership in improving public employee performance and offers important implications for the development of transformational leadership in the context of government
THE EFFECT OF ACCOUNTABILITY ON EMPLOYEE PERFORMANCE IN GOVERNMENT AGENCIES
Authors: Sofyan Meti Mediyastuti
Published: August 2023

Improving the performance accountability of government agencies is one of the important challenges faced in the era of demands for quality public services. The Bandung Regency Government as one of the regions in Indonesia also faces similar challenges. Therefore, this study aims to analyze the performance accountability of government agencies in the Bandung Regency Government. Researchers used quantitative research. Research Subject The research subject is a line or research boundary that is useful for researchers in determining objects or people as the point of attachment of research variables. Bandung Regency Civil Service Police Unit Office. Regional Technical Institutions The determination of the sample was carried out based on consideration of the significance of the agency in the delivery of public services and the representativeness of various government sectors. In selecting the sample, it is also necessary to consider the variation in the size of agencies as well as the diversity of their functions and responsibilities to cover various aspects of relevant public services. The results showed that the condition of performance accountability of government agencies in the Bandung Regency Government still needs to be improved. Factors that influence performance accountability include good leadership and management, effective internal control systems, public participation in supervision, and financial transparency and accountability.
CAPTURING THE REALITY OF INDUSTRY 4.0 READINESS DIMENSIONS AND INDICATORS IN A DEVELOPING COUNTRY: AN ANALYSIS OF APPLYING I4.0 IN INDONESIA
Authors: Hasbullah Hasbullah , Bareduan Salleh Ahmad
Published: August 2023

Indonesia has the lowest Industry 4.0 (I4.0) readiness in South East Asia, and uses the INDI 4.0 instrument (Indonesia Industry 4.0 readiness index), which is not as comprehensive and accurate as it could be. An Initial survey confirmed that only 56.86% of respondents agreed that INDI 4.0 accurately measured readiness in manufacturing operations. Unlike the primary I4.0 indices, INDI 4.0 lacks comprehensive I4.0 dimensions and characteristics. This paper aims to identify the dimensions and indicators of I4.0 readiness to enhance INDI 4.0 through an exploratory mixed-method research approach with a multiphase research design. The first phase consisted of a qualitative approach through a documentary review, interviews, and observations to explore the dimensions and indicators of I4.0 readiness. This phase successfully identified four dimensions that experts, academics, and practitioners validated: technology, data life cycle, I4.0 design principles, and smart factory. These dimensions were broken down into 27 indicators of I4.0 readiness, then validated again through a statistical approach before being affirmed by a survey with a Pearson’s correlation > 0.361 and Cronbach’s alpha of 0.987, which indicated validity and reliability. The second phase, using a quantitative approach through a survey, confirmed the four dimensions and 27 indicators for measuring I4.0 readiness levels; these were ‘not ready’, ‘early stage’, ‘moderate readiness’, ‘readiness ripe’, and ‘already implemented’. This finding comprehensively measured I4.0 readiness based on feedback from industries struggling to adopt I4.0, especially in developing countries such as Indonesia. This finding also differed from existing indices (Acatech, RAMI 4.0, Dreamy, SIMMI 4.0. IMPULS) from developed countries and industries already stable in implementing I4.0. eywords: (Industry 4.0, I4.0 readiness indicators, INDI 4.0)
ASSESSING ORGANISATIONS’ READINESS TO ADOPT GREEN INFORMATION TECHNOLOGY: THE CASE OF A SOUTH AFRICAN INFORMATION TECHNOLOGY SERVICES VENDOR
Authors: Muranganwa Isaac , Naidoo Rennie
Published: August 2023

Green information technology (IT) adoption is an important topic in the fields of information systems, business sustainability, and corporate social responsibility. This case study applies the green IT adoption model (GITAM) to perform a systematic and qualitative readiness assessment at a major South African IT services vendor. Thematic data analysis was used to analyse the data collected from managers and specialist IT staff. The assessment revealed that the main organisational adoption readiness barriers were the lack of a formal green IT policy, an unclearly defined green IT governance framework, and a lack of green performance management. The main drivers of adoption were economic imperatives and regulatory and ethical requirements. Interestingly, a contextual variable – an exogenous shock caused by COVID-19 and the robustness of the organisation’s crisis response during the pandemic – rapidly increased the rate of green IT adoption at the firm. Keywords: Corporate Social Responsibility, Green IT Adoption Model (GITAM), Case Study, G-readiness Assessment, Green IT, Sustainability, Technology Adoption
Factors influencing health-related quality of life for young single-person households: the mediating effect of resilience
Authors: Lee Soo Jin , Lee Sujin , Jin Xianglan
Published: August 2023

Purpose: To identify factors influencing health-related quality of life for young single-person households, this study investigated physical and mental health status, health behavior, depression, resilience, and health-related quality of life. Methods: An online survey was administered to members of young single-person households from March 22 to 30, 2022. The data were analyzed using the chi-square test, independent t-test, one-way analysis of variance, Pearson correlation coefficients, multiple regression, and a simple mediation model applying the PROCESS macro model 4 with 95% bias-corrected bootstrapped confidence intervals. Results: The participants were 229 members of young single-person households. Health-related quality of life showed significant relationships with residence (t = 2.80, p = .006), monthly income (F = 3.70, p = .026), mental health status (F = 20.33, p < .001), and high-intensity exercise (F = 7.35, p = .001) among general and health-related characteristics. Health-related quality of life had significant correlations with depression (r = -.72, p < .001) and resilience (r = .58, p < .001). Multiple regression analysis showed that depression (β = -.57, p < .001) and resilience (β = .21, p < .001) influenced health-related quality of life. Moreover, resilience had a mediating effect between depression and health-related quality of life (indirect effect = -0.002, 95% bias-corrected bootstrapped confidence interval = -0.003 to -0.001). Conclusion: Members of young single-person households tended to be more vulnerable to emergency situations, such as during the coronavirus disease 2019 pandemic, when lockdowns and quarantines were frequent. To improve health-related quality of life in young single-person households, people with high levels of depression or low levels of resilience need special attention and support to promote mental health.
Differences in physical function, self-efficacy, and health-related quality of life by disease severity in community-dwelling patients with chronic obstructive pulmonary disease
Authors: Song Hee-Young , Nam Kyoung A
Published: August 2023

Purpose: This study investigated the differences in physical function, self-efficacy (SE), and health-related quality of life (HRQoL) categorized by disease severity in community-dwelling patients with chronic obstructive pulmonary disease (COPD). Methods: This cross-sectional study included 182 patients with COPD selected from the pulmonology outpatient department of a tertiary hospital. Disease severity was measured using forced expiratory volume in 1 second (FEV1). Physical function, SE, and HRQoL were measured with the six-minute walking distance, pulmonary rehabilitation self-efficacy (PRAISE), and St. George's Respiratory Questionnaire (SGRQ). Disease duration, FEV1, and 12-month history of exacerbations were obtained from medical records. Patients were categorized by Global Initiative for Chronic Obstructive Lung Disease (GOLD) category. Data were analyzed using the two-sample t-test, χ2 test, and one-way ANOVA. Results: Most of the participants were male and nonsmokers. The disease duration was 10.76 ± 10.03 years, the mean FEV1% was 62.13 ± 22.80, and 70.3% of the participants were in GOLD category 2 (moderate) or milder. Half of the participants reported modified Medical Research Council scores ≥ 2. Patients in GOLD categories 1 and 3 (mild and severe) exhibited significantly higher PRAISE scores than those in the other groups (F = 8.23, p < .001). The total SGRQ scores were highest in GOLD 4 (very severe), indicating the lowest HRQoL. Significant differences were identified among GOLD 1, GOLD 2 and 3, and GOLD 4 (F = 9.92, p < .001). Conclusion: We identified potentially useful variables to comprehensively assess disease severity and tailor management strategies, including airflow limitation, and to determine the consequences of COPD from patients’ perspectives.
Nursing Care of HIV-Positive Women: A Scoping Literature Review on the Emotional Challenges for Women Living with a Chronic Disease
Authors: Nielsen Ben Farid Røjgaard , Martinsen Bente
Published: August 2023

Living with HIV seems to be more stressful for women than men. Women exhibit higher levels of depression, lower levels of well-being and lower quality of life than HIV-infected men do. The aim of the review is to provide a comprehensive gender specific knowledge about the emotional challenges HIV infected women face in their daily lives. Across all articles one theme that emerged was the challenges about the social environment after being diagnosed with HIV. Three identified show what challenges women with HIV are facing in relation to employment, in relation to other people and a fear of stigma. Another theme that emerged was the challenges of different coping mechanisms. There was an evolution in how an HIV diagnosis had affected women’s lives and their ability to cope with their diagnoses. Three identified subthemes show what challenges women with HIV are facing in relation to aiming to improve quality of life after being diagnosed with HIV, a sharp distinction between HIV and AIDS and a religious and spiritually coping. Identifying the emotional challenges women living with HIV face in their daily lives may help nurses obtain a clearer understanding and greater knowledge of how to provide HIV-positive women with effective care that empower and support these women in managing their chronic disease. However to ensure that nurses have the proper tools for effective care for women living with HIV European studies are essentials in relation to what emotional challenges these women are facing in their daily lives.
Impact of Micro Health Insurance Plans on Protecting Households Against Catastrophic Health Spending in Tanzania
Authors: Kihaule Arnold
Published: August 2023

The paper analyses the impact of households’ membership in micro health insurance plans on the protection against catastrophic health spending, in the episodes of illness. The analysis considers the groups of poor and non-poor members of micro health insurance schemes and non-members in both urban and rural areas in Tanzania.

Matching estimator method was used to analyse the effect of membership in the micro health insurance on the protection against catastrophic health spending, in the episodes of illness among the members of micro health insurance scheme and non-members for the different income groups. Data used in the analysis involved those on the 10,300 households involved in Tanzania Demographic and Health Survey of 2011.

The estimation results revealed that insurance schemes enabled households to get protection against catastrophic health spending, in the episodes of illness to members of insurance schemes compared to non-members. Thus, it is recommended that households be encouraged to enroll in the micro health insurance schemes. The insurance scheme also needs to be close to the would be customers. This will also contribute to poverty reduction in the country as well.
A Model worth Sharing: A Community Mental Health Clinic with an Award Winning Integrated Physical Health Program
Authors: Wallace Elizabeth
Published: August 2023

The lifespan of people with severe mental illness (SMI) is shorter compared to the general population. This excess mortality is mainly due to physical illness. (De Hert et al 2011). Mental health services should be able to provide at least a standard routine assessment of their patients, in order to identify or suspect the presence of physical health problems. (Maj, M 2009)

The first step in addressing the gap between psychiatric and health management is to integrate physical health into mental health planning. (Miller, H 2008)

The paper provides an overview of the innovative nurse led Physical Health Program which has successfully integrated into the core business of a community mental health clinic within Melbourne’s public health service and created working partnerships with primary care and community health.

The Program received recognition as Gold Winner in the Excellence in Person Centred Care category at the Victorian Public Health Awards in 2014 and has been in place for three years, providing physical health screening, signposting and individual evidence based interventions to consumers with severe mental illness.

Dedicated nursing roles and the development of a unique approach provides a barrier free long term care model which has returned high rates of engagement with consumers in addressing their physical health needs and goals.

The model, which has been promoted for replication across the service, showcases best practice, the value of collaborative working with our community health and primary care partners, and the substantial progress and effective outcomes that can be achieved when a mental health nurses takes the lead in innovation and change.
Low-dose lipopolysaccharide inhibits spinal cord injury-induced neuronal apoptosis by regulating autophagy through the lncRNA MALAT1/Nrf2 axis
Authors: Hu Jianhua , Huang Kun , Bao Feilong , Zhong Shixiao , Fan Qianbo , Li Weichao
Published: August 2023

Background

Spinal cord injury (SCI) is a neurological disease associated with a high disability rate. Low-dose lipopolysaccharide (LPS) has been reported to activate cross-immune tolerance and alleviate the effects of various traumatic stimuli. The present study aimed to explore the effect of LPS on SCI and the potential molecular mechanism.

Methods

Male Sprague-Dawley (SD) rats were used to established an in vivo SCI model and were intraperitoneally injected with lentivirus particles encoding a MALAT1 small interfering RNA (siRNA) on day 10 prior to SCI and with 0.2 mg/kg LPS 72 h prior to SCI. Basso, Beattie, and Bresnahan (BBB) scoring; HE staining; and TUNEL assay were used to assess neurological function and pathophysiological changes. Western blot and immunohistochemistry (IHC) were used to detect cell autophagy and Nrf2 nuclear translocation. PC12 cells were exposed to oxygen-glucose deprivation/reoxygenation (OGD/R) to establish an in vitro SCI model. In vitro SCI model cells were pretreated with LPS and transfected with siMALAT1 or MALAT1 overexpression plasmid aimed at knocking down MALAT1 or overexpressing MALAT1. The cell counting kit-8 (CCK-8) assay was used to measure the toxicity of LPS towards PC12 cells. Flow cytometry and immunofluorescence analysis were performed to investigate cell apoptosis and Nrf2 nuclear translocation.

Results

SCI rats preconditioned with low-dose LPS had higher BBB scores, reduced SCI injury, increased MALAT1 expression and activated autophagy and Nrf2 nuclear translocation in the in vivo SCI model. In the in vitro SCI model, low-dose LPS treatment suppressed the apoptotic ratio of PC12 cells, increased MALAT1 expression, activated autophagy, and promoted Nrf2 nuclear translocation. Silencing MALAT1 exacerbated OGD/R injury in vitro and weakened the protective effect of low-dose LPS. Overexpression of MALAT1 inhibits OGD/R-induced apoptosis by inducing autophagy and promoting Nrf2 nuclear translocation. This was also been confirmed in animal experiments, silencing MALAT1 blocked the promotion of Nrf2 by low-dose LPS and the alleviated of SCI apoptosis.

Conclusions

Low-dose LPS exhibited a protective role on SCI by activating autophagy and suppressing nerve cell apoptosis via the lncRNA MALAT1/Nrf2 axis.
Diversity analysis of Populus euphratica endophytic bacteria in Tarim River Basin, China
Authors: Cheng Gang , Cheng Yan , Rahman Erkin
Published: August 2023

The bacterial diversity in Populus euphratica stem storage liquid samples grown in Shaya County and Yuli County of the Tarim River Basin was investigated. A culture-dependent (dilution spread plate method) and culture-independent method (PCR-RFLP technique) were used to identify the endophytic bacteria community structure and composition in P. euphratica in Tarim River Basin. Sixty-six bacterial strains were isolated from P. euphratica stem storage liquid samples on three agar media. The 16S rDNA gene was amplified and sequenced using bacterial universal primers. Phylogenetic analysis showed that the 66 strains belonged to three phyla (Firmicutes, Actinomycetes, and Gamma-Proteobacteria) and included 16 genera and 29 species. Among them, Pseudomonas (27.27%) and Bacillus (19.69%) were the dominant isolates. CGM-17 was a potentially new species of Pantoea. Restriction fragment length polymorphism of 16S rDNA gene amplified by polymerase chain reaction (PCR-RFLP) revealed 48 operational taxonomic units (OTUs). Phylogenetic analysis indicated that the 48 OTUs belonged to Firmicutes, Actinobacteria, Proteobacteria (α-, β-, γ-subgroup), Bacteroidetes, and Verrucomicrobia. Gamma-Proteobacteria was the dominant group, similarly to the culture-dependent method, accounting for 53% of the entire bacterial clone library. Our results indicate that P. euphratica endophytic bacteria diversity in the Tarim River Basin was rich, and the resources of endophytic bacteria were high. They provide valuable reference data and species resources for screening indigenous and functional strains of endophytic bacteria in P. euphratica.
Identification of Zip8-correlated hub genes in pulmonary hypertension by informatic analysis
Authors: Zhao FanRong , Chen Yujing , Xie Yuliang , Kong Shuang , Song LiaoFan , Li Hanfei , Guo Chao , Yin Yanyan , Zhang Weifang , Zhu Tiantian
Published: August 2023

Background

Pulmonary hypertension (PH) is a syndrome characterized by marked remodeling of the pulmonary vasculature and increased pulmonary vascular resistance, ultimately leading to right heart failure and even death. The localization of Zrt/Irt-like Protein 8 (ZIP8, a metal ion transporter, encoded by SLC39A8) was abundantly in microvasculature endothelium and its pivotal role in the lung has been demonstrated. However, the role of Zip8 in PH remains unclear.

Methods

Bioinformatics analysis was employed to identify SLC39A8 expression patterns and differentially expressed genes (DEGs) between PH patients and normal controls (NC), based on four datasets (GSE24988, GSE113439, GSE117261, and GSE15197) from the Biotechnology Gene Expression Omnibus (NCBI GEO) database. Gene set enrichment analysis (GSEA) was performed to analyze signaling pathways enriched for DEGs. Hub genes were identified by cytoHubba analysis in Cytoscape. Reverse transcriptase-polymerase chain reaction was used to validate SLC39A8 and its correlated metabolic DEGs expression in PH (SU5416/Hypoxia) mice.

Results

SLC39A8 expression was downregulated in PH patients, and this expression pattern was validated in PH (SU5416/Hypoxia) mouse lung tissue. SLC39A8-correlated genes were mainly enriched in the metabolic pathways. Within these SLC39A8-correlated genes, 202 SLC39A8-correlated metabolic genes were screened out, and seven genes were identified as SLC39A8-correlated metabolic hub genes. The expression patterns of hub genes were analyzed between PH patients and controls and further validated in PH mice. Finally, four genes (Fasn, Nsdhl, Acat2, and Acly) were downregulated in PH mice. However, there were no significant differences in the expression of the other three hub genes between PH mice and controls. Of the four genes, Fasn and Acly are key enzymes in fatty acids synthesis, Nsdhl is involved in cholesterol synthesis, and Acat2 is implicated in cholesterol metabolic transformation. Taken together, these results provide novel insight into the role of Zip8 in PH.
Comprehensive transcriptional analysis of pig facial skin development
Authors: Li Yujing , Shi Rui , Yuan Rong , Jiang Yanzhi
Published: August 2023

Background

Skin development is a complex process that is influenced by many factors. Pig skin is used as an ideal material for xenografts because it is more anatomically and physiologically similar to human skin. It has been shown that the skin development of different pig breeds is different, and some Chinese pig breeds have the characteristics of skin thickness and facial skin folds, but the specific regulatory mechanism of this skin development is not yet clear.

Methods

In this study, the facial skin of Chenghua sows in the four developmental stages of postnatal Day 3 (D3) , Day 90 (D90) , Day 180 (D180), and Year 3 (Y3) were used as experimental materials, and RNA sequencing (RNA–seq) analysis was used to explore the changes in RNA expression in skin development at the four developmental stages, determine the differentially expressed messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), and perform functional analysis of related genes by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.

Results

A pairwise comparison of the four developmental stages identified several differentially expressed genes (DEGs) and found that the number of differentially expressed RNAs (DE RNAs) increased with increasing developmental time intervals. Elastin (ELN) is an important component of the skin. Its content affects the relaxation of the epidermis and dermal connection, and its expression is continuously downregulated during the four developmental stages. The functions of DEGs at different developmental stages were examined by performing GO and KEGG analyses, and the GO terms and enrichment pathways of mRNAs, lncRNAs, miRNAs, and circRNAs highly overlapped, among which the PPAR signaling pathway, a classical pathway for skin development, was enriched by DEGs of D3 vs. D180, D90 vs. D180 and D180 vs. Y3. In addition, we constructed lncRNA-miRNA-mRNA and circRNA-miRNA interaction networks and found genes that may be associated with skin development, but their interactions need further study.

Conclusions

We identified a number of genes associated with skin development, performed functional analyses on some important DEGs and constructed interaction networks that facilitate further studies of skin development.
Análisis de la integración de la conciencia ambiental en la educación ambiental del currículo chileno
Authors:   Pontificia Universidad Católica de Valparaíso (Chile), Núñez Tobar Javiera , Vargas Navarrete Natalia ,   Pontificia Universidad Católica de Valparaíso (Chile), Valdebenito Pérez Alexi ,   Pontificia Universidad Católica de Valparaíso (Chile), Lizama Orellana Andrea ,   Pontificia Universidad Católica de Valparaíso (Chile), Oyarzún Morel Juan de Dios ,   Pontificia Universidad Católica de Valparaíso (Chile)
Published: August 2023

El objetivo del estudio consistió en analizar la propuesta de educación ambiental del currículo nacional en las asignaturas de Ciencias Naturales e Historia, Geografía y Ciencia Sociales para establecer los modos en los que integra el desarrollo de la conciencia ambiental. La metodología fue un análisis documental cualitativo con base en las dimensiones de la conciencia ambiental: cognitiva, afectiva, disposicional y comportamental. Los hallazgos evidencian que la conciencia ambiental se incorpora de forma desbalanceada y parcial, con un dominio de lo cognitivo y disposicional por sobre lo afectivo y comportamental. El currículo propone de forma escasa el estudio de problemas y conflictos ambientales, valora de modo instrumental al medioambiente, y fomenta acciones de poco impacto frente a la crisis ecológica global.
Perfiles de actitudes hacia la equidad de género entre adolescentes latinoamericanos
Authors:   University of Bath (England), López-Hornickel Natalia , Sandoval-Hernández Andrés ,   University of Bath (England)
Published: August 2023

Las actitudes hacia la igualdad de género son fundamentales para la ciudadanía porque pueden fomentar condiciones de vida más igualitarias. La evidencia muestra que las actitudes que se oponen a la igualdad de derechos entre hombres y mujeres se relacionan negativamente con la igualdad de género. Asimismo, entre los adolescentes, estas actitudes pueden reproducir estereotipos que limitan las oportunidades de mujeres jóvenes y crean conductas de riesgo, especialmente entre hombres jóvenes. Sin embargo, el conocimiento sobre la adherencia a las actitudes de género entre los adolescentes aún es escaso en América Latina. Este artículo busca identificar perfiles de adhesión a las actitudes hacia la equidad de género en cinco países de América Latina: Chile, Colombia, República Dominicana, México y Perú. Se desarrolló un análisis simultáneo de clases latentes a través de grupos considerando la escala Aprobación de la equidad de género por parte de los estudiantes del Estudio Internacional de Educación Cívica y Ciudadana (ICCS) 2016 de la IEA. Este enfoque analítico permite comparar diferentes contextos utilizando un modelo estructuralmente equivalente (homogéneo). Identificamos cuatro perfiles diferentes en función de los elementos incluidos en el análisis, con diferentes niveles de prevalencia en cada país analizado: completamente igualitarios, sexistas normativos, igualitarios vacilantes y sexistas políticos. La importancia de este trabajo radica en la idea de que los ciudadanos activos necesitan comprender conceptos, principios y habilidades para ser responsables y reflexivos, pero también necesitan estar comprometidos con valores democráticos. En este escenario, es fundamental comprender el estado actual de la adhesión a la equidad de género para la construcción de sociedades más justas e inclusivas.
Involucramiento, implicación y participación de las familias: explorando enfoques, niveles y ámbitos de acción en políticas de cuatro países latinoamericanos
Authors:   Universidad Finis Terrae (Chile), Gubbins Verónica , Urrutia Mauricio ,   London School of Economics and Political Science (Inglaterra), Cárcamo Héctor ,   Facultad de Educación y Humanidades, Universidad del Bío Bío (Chile)
Published: August 2023

El cese de las actividades escolares presenciales a raíz de la pandemia por COVID-19 situó la participación de las familias en un lugar central en las reflexiones y procesos de toma de decisiones de los gobiernos, las escuelas y las propias familias. La incertidumbre respecto de su remisión delinea un escenario complejo para la definición de políticas de participación de las familias a largo plazo. La necesidad de avanzar en lineamientos para el trabajo de las escuelas y las familias invita a preguntarse acerca de los enfoques, niveles y ámbitos de la participación de las familias que se promueven desde las políticas. Se presentan los resultados de un estudio documental cualitativo, de carácter exploratorio, de políticas de cuatro países latinoamericanos. Se concluye que las políticas no abordan un modelo único de participación. Estas tienden a abordar enfoques con propósitos, niveles y ámbitos de acción diferentes, cuya traducción puede resultar confusa o contradictoria para los profesionales de las escuelas y las familias. Esta información puede servir de referencia para las decisiones de políticas, planes y programas que los gobiernos, las escuelas, los docentes y las instituciones de formación inicial de profesionales de la educación vayan tomando post pandemia.
Composición emocional: dinámicas de composición para un teatro físico a través de un entrenamiento actoral basado en el método Alba Emoting
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Artes, Valencia Fernández Pablo Leopoldo Nicolás
Published: August 2023

Esta investigación-creación plantea la exploración de un entrenamiento actoral creado a partir del método de inducción emocional Alba Emoting. Enmarcado en el área del teatro físico, y con el objetivo de proponer una metodología de creación para una puesta en escena, este trabajo pretende explorar, experimentar y generar “dinámicas de composición” a partir de la improvisación basada en los patrones efectores propuestos por las seis emociones básicas según Alba Emoting.
On the geography of 3-folds via asymptotic behavior of invariants
Authors:   ,   Pontificia Universidad Católica de Chile. Facultad de Matemáticas, Torres Nova Yerko Alejandro
Published: August 2023

Roughly speaking, the problem of geography asks for the existence of varieties of general type after we fix some invariants. In dimension 1, where we fix the genus, the geography question is trivial, but already in dimension 2 it becomes a hard problem in general. In higher dimensions, this problem is essentially wide open. In this paper, we focus on geography in dimension 3. We generalize the techniques which compare the geography of surfaces with the geography of arrangements of curves via asymptotic constructions. In dimension 2 this involves resolutions of cyclic quotient singularities and a certain asymptotic behavior of the associated Dedekind sums and continued fractions. We discuss the general situation with emphasis in dimension 3, analyzing the singularities and various resolutions that show up, and proving results about the asymptotic behavior of the invariants we fix.
Social Change in the Kampung Sejahtera Village of Medan City, Indonesia
Authors: Saputra Agung , Ibrahim Jabal Tarik , Sukmana Oman , Rudianto
Published: August 2023

Aims: This study aims to analyze the social changes that have taken place in Kampung Sejahtera, Medan City, Indonesia. This social change was motivated by the community's desire to change the bad stigma attached to this area which is synonymous with drug trafficking, prostitution, gambling and other criminal acts into a village that is safe, comfortable, beautiful, prosperous and livable.

Place and Duration of Study: This study was conducted in Kampung Sejahtera, Medan City, Indonesia. The research started from May 2022 to July 2023

Methodology: This study uses a qualitative approach. This qualitative approach was chosen to find out how social changes have occurred in the people living in the Prosperous Village of Medan City. The type of study used in this study is a case study. In simple terms, the case study in this study is defined as a process of in-depth and detailed investigation or examination of social change events that occurred in the Prosperous Village of Medan City.

Results: Social change in Kampung Sejahtera, Medan City, Indonesia occurs through demographic processes, economic processes, ideas and social movements that have been going on for a long time.

Conclusion: The social change that occurred in Kampung Sejahtera, Medan City was motivated by the people's desire to change the reputation of Kampung Kubur as a slum village and drug den inhabited by criminals to become a Prosperous Village that is safe, comfortable and conducive. The social changes that occurred in Kampung Sejahtera were generally initiated by figures from the community, government figures and the Police. The social changes that have occurred have changed the social structure that has occurred for the better. This can be seen in the reduction in drug trafficking and abuse, the creation of a better, beautiful and comfortable social environment as well as changes in the outside community's assessment of the bad reputation that was previously popular from Kampung Kubur to Kampung Sejahtera.
Evaluation of Storage and Disposal of Household Waste in the City of Kinshasa (Communes of Lemba, Mont-Ngafula, and Kisenso) and Awareness of Eco-Citizenship
Authors: Frey Sylvestre , Anzola Nestor K. , Makanua Diansambu
Published: August 2023

This study aims to analyze and describe the characteristics of household waste in the communes of Lemba, Mont-Ngafula and Kisenso in Kinshasa, while raising awareness of ecological citizenship. The study was conducted from April 17 to May 3, 2023, with a sample of 690 households, 138 randomly selected from each community. The main methods used are survey, interview and observation in the field.

The results show that household waste management in the cities studied does not contribute to sustainable development. Most households use garbage cans, mainly buckets and bags, but waste sorting is rare, except in the Kindele area. The most common waste disposal methods are inappropriate local disposal and incineration. The most common methods of waste disposal are disposal in inappropriate locations and incineration. Average waste weights vary by neighbourhood, with values ranging from 8.67 kg to 13.99 kg per household. It has a significant correlation between the total weight of waste generated per household and household size.

The findings of the study indicate that the state of household waste management in these cities is worrying, with adverse consequences for the environment and public health. Proposals include new laws to regulate waste management, integration of waste management into urban development plans, establishment of landfills and public awareness of sanitation rules and the principles of waste reduction, reuse and recycling. Developing effective and sustainable strategies to address household waste management in these communities in Kinshasa is crucial. The involvement of local authorities, stakeholders and citizens is essential to protect the environment.
Effects of Different Pretreatments on Physico-chemical Properties of Potato Chips Fried in Different Oils
Authors: Yadav Awadhesh Kumar , Chandra Suresh , Kumar Tarun , Chandra Deepika , Puja  , Mudgal Deepali , Kumar Vijai , Kumar Pawan
Published: August 2023

The objective of this study was to develop potato chips applying deep frying technique. The potato chips were deep-fried at 180ºC for 13-72 sec. Physicochemical properties of the prepared chips, such as moisture content, ash content, pH, acidity, color (L*, a*, b*), and whitening index. Colors of fried in mustard oil, sunflower oil, groundnut oil and canola oil potato chips blackness to lightness, green to red and blue to yellow range of L* (34.08-75.98), a* (-3.32 to + 3.9) b* (7.33- 44.15),. The whiteness index of the potato chips was found 9.50-25.30. The maximum acceptability of potato chips fried at 180 °C in mustard oil, sunflower oil, groundnut oil, and canola oil to consumer panelists was T3 (7.90), T3 (8.00), T3 (7.87), and T4 (7.84), respectively.
Enhancing Growth and Yield of Parching Sorghum through Organic Manure Application
Authors: Potadar Jyoti , Patil M. B. , Nooli S. S.
Published: August 2023

Aims: The combination of various sources of organic manures along with liquid organic manures is important to maintain nutrient availability to crop and sustain higher level of soil fertility. The aim is to meet the nutrient demand of parching sorghum as per requirement at different stages through solid and liquid organic manures which can give greater productivity of crops.

Study Design: The experiment was laid in Randomized Complete Block Design with 9 treatments replicated thrice.

Place and Duration of Study: A field experiment was conducted at College of Agriculture, Vijayapur, during Rabi, 2020-21.

Methodology: The treatments were T1-Ghanajeevamrutha based on 100% RDN (recommended dose of Nitrogen) as basal dose, T2-Vermicompost based on 100% RDN as basal dose, T3- T1 + foliar application of 10% vermiwash at 20 & 45 DAS (days after sowing), T4- T1 + foliar application of 10% cow urine at 20 & 45 DAS, T5- T1 + foliar application of 25% jeevamrutha at 20 & 45 DAS, T6- T2 + foliar application of 10% vermiwash at 20 & 45 DAS, T7- T2 + foliar application of 10% cow urine at 20 & 45 DAS, T8- T2 + foliar application of 25% jeevamrutha at 20 & 45 DAS and T9- Organic RPP of parching sorghum with SMJ-1 variety of parching sorghum.

Results: The application of ghanajeevamrutha based on 100 per cent RDN as basal dose + foliar application of 25 per cent jeevamrutha at 20 and 45 days after sowing recorded significantly higher dry matter production (55.86 g plant-1), leaf area index (3.49), raw and roasted grain weight (39.49 g and 51.73 g respectively), raw and roasted grain yield (1063 kg ha-1 and 1505 kg ha-1 respectively) of parching sorghum (hurda) at harvest as compared to other treatments. In addition to improvement in the major plant nutrient uptake were recorded with incorporation of ghanajeevamrutha or vermicompost along with the liquid organic manure.

Conclusion: The application of ghanajeevamrutha based on 100 per cent RDN as basal dose coupled with foliar application of 25 per cent jeevamrutha at 20 and 45 days after sowing recorded significantly higher growth, yield, quality and plant nutrient uptake by parching sorghum.
Efficient Use of Nano-fertilizer for Increasing Productivity and Profitability along with Maintain Sustainability in Rice Crop: A Review
Authors: Kumar Mandeep , Singh Y. K. , Maurya Shravan Kumar , Maurya Sandeep Kumar , Maurya Durgesh Kumar , Sachan Ravindra , Gautam Mahendru Kumar , Tiwari Abhishek
Published: August 2023

The need for food and the expanding global population have put enormous pressure on agriculture to increase crop yield while preserving sustainability. Since rice is a staple diet for millions of people, novel methods are needed to increase yields without harming the environment. The possible advantages of using nano fertilizers in rice farming are examined in this abstract in order to raise yields, increase farmer profitability, and ensure long-term sustainability. Nano-sized carriers created for effective nutrient delivery to crops are called nano fertilizers, an innovative application of nanotechnology in agriculture. Their special qualities, such as their large surface area and regulated release mechanisms, allow for the targeted supply of nutrients to rice plants, improving nutrient uptake and utilization. Nano-fertilizers successfully optimize nutrient availability as a consequence, increasing crop output. According to studies, using nano fertilizers in rice farming increases grain yields because plants are better able to absorb and assimilate nutrients. The crop's resistance to environmental challenges and disease strains is strengthened as a result of this enhanced nutrient utilization, which also boosts yield and contributes to sustainable rice farming practices. Furthermore, nano fertilizers offer cost-effectiveness and increased profitability for farmers. Despite their initial higher cost, the efficient nutrient delivery of nano fertilizers reduces the overall application rate required compared to conventional fertilizers. This reduction in input costs translates to improved profitability for farmers, promoting economic sustainability in rice production.