bluuebunny/crossref_metadata_2025 huggingface dataset:
Demographic and Clinical Parameters Along with Hormonal Levels in Pediatric Patients with Chronic Kidney Disease: A Study of Pubertal Development Impacts
Authors: Önal Hülya Gözde , Önal Mesut , NALÇACIOĞLU Hülya , KARALI Demet Tekcan KARALI TEKCAN
Published: July 2023

Objective: Chronic kidney disease (CKD) is associated with growth retardation and delayed pubertal development in the pediatric population. This study aimed to investigate the impact of CKD on growth and pubertal development in children and adolescents by considering factors such as dialysis and transplantation.
Methods:A cross-sectional retrospective study was conducted in a cohort of 52 pediatric patients aged 0-18 diagnosed with stages 2-5 CKD, undergoing dialysis treatment or kidney transplantation. Demographic information, clinical characteristics, pubertal development, and treatment methods were also collected. The relationships between these factors and pubertal development were also analyzed.
Results:This study revealed significant delays in growth and pubertal development in children and adolescents with CKD. The mean age at menarche was 12.79, and 32.8% of the patients had primary amenorrhea. Patients on dialysis and those who underwent transplantation displayed further growth and pubertal outcomes. Factors such as the CKD stage (r = 0.35, p = 0.02) and age at diagnosis (r = -0.28, p = 0.01) significantly influenced the relationship between CKD and pubertal development. Results were associated with delayed pubertal growth in this population.
Conclusion:Our findings underscore the significant impact of CKD on the growth and pubertal development of children and adolescents. Early detection, intervention, and comprehensive management of CKD and its complications could aid in improving growth and pubertal outcomes in this vulnerable population.
Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection
Authors: Hamadani Christine M. , Dasanayake Gaya S. , Chism Claylee M. , Gorniak Meghan E. , Monroe Wake G. , Merrell Anya , Pride Mercedes C. , Heintz Rebekah , Wong Karen , Hossain Mehjabeen , Taylor George , Edgecomb Sara X. , Jones Deauntaye , Dhar Joy , Banka Alison , Singh Gagandeep , Vashisth Priyavrat , Randall Joh'nis , Darlington Donovan S. , Everett Jaylon , Jarrett Ethan , Werfel Thomas A. , Eniola-Adefeso Omolola , Tanner Eden E. L.
Published: July 2023

Less than 5% of intravenously-injected nanoparticles (NPs) reach destined sites in the body due to opsonization and immune-based clearance in vascular circulation. By hitchhiking in situ onto specific blood components post-injection, NPs can selectively target tissue sites for unprecedentedly high drug delivery rates. Choline carboxylate ionic liquids (ILs) are biocompatible liquid salts <100℃ composed of bulky asymmetric cations and anions. This class of ILs has been previously shown to significantly extend circulation time and redirect biodistribution in BALB/c mice post-IV injection via hitchhiking on red blood cell (RBC) membranes. Herein, we synthesized & screened 60 choline carboxylic acid-based ILs to coat PLGA NPs and present the impact of structurally engineering the coordinated anion identity to selectively interface and hitchhike lymphocytes, monocytes, granulocytes, platelets, and RBCs in whole mouse blood for in situ targeted drug delivery. Furthermore, we find this nanoparticle platform to be biocompatible (non-cytotoxic), translate to human whole blood by resisting serum uptake and maintaining modest hitchhiking, and also significantly extend circulation retention over 24 hours in BALB/c healthy adult mice after IV injection. Because of their altered circulation profiles, we additionally observe dramatically different organ accumulation profiles compared to bare PLGA NPs. This study establishes an initial breakthrough platform for a modular and transformative targeting technology to hitchhike onto blood components with high efficacy and safety in the bloodstream post-IV administration.
Epidemiology of Autism Spectrum Disorder in Buenos Aires, Argentina: Insights from Unique Disability ID Issuance Trends
Authors:   Agustina Aragón-Daud1, Vetere Giselle , Argañaraz Marina , Musich Francisco
Published: July 2023

Purpose: Autism Spectrum Disorder (ASD) prevalence rates vary greatly across regions and studies. Some countries, such as Argentina, have unknown rates. Due to this high heterogeneity in ASD prevalence worldwide, it is important to study its prevalence and characteristics in such countries to develop effective policies.
Methods: we analyzed official data from the Unique Disability IDs (UDIDs) issued for individuals with ASD in the Autonomous City of Buenos Aires from 2016 to 2021, examining age, gender, and diagnosis.
Results: most UDIDs were issued for males, for Pervasive Developmental Disorders, and almost half to individuals over 8 years old, with these trends remaining stable over these years. However, UDID issuance abruptly dropped in 2020.
Conclusions: our findings highlight epidemiological aspects of the autism population in Argentina, including challenges such as delayed diagnosis and high prevalence of broad diagnosis categories. Addressing these challenges requires further research and intervention to improve the quality of life of individuals with ASD.
Solutions to weighted complex m-Hessian equations on domains in Cn
Authors: Phu Nguyen Van , Dieu Nguyen Quang
Published: July 2023

In this paper, we first study the comparison principle for the operator Hχ,m. This result is used to solve certain weighted complex m- Hessian equations.
2010 Mathematics Subject Classification: 32U05, 32W20.
Circulation of Chikungunya virus in Rio Grande do Norte from 2019 to 2020: epidemiological and molecular aspects
Authors: Dias Jonai Pachêco , Pereira Raíssa Liane do Nascimento , Dantas Maria Eduarda Pessoa Lopes , Monteiro Joelma Dantas , Pereira Hannaly Wana Bezerra , de Oliveira Derley Galvão , de Souza Themis Rocha , de Araújo Josélio Maria Galvão
Published: July 2023

Background:
Once considered a third-world disease, Chikungunya Fever is currently one of the main emerging arboviruses globally. Shortly after having been established as an autochthonous disease in Brazil, Chikungunya virus (CHIKV) spread in the State of Rio Grande do Norte, where it has caused recurrent outbreaks. This study aims to describe epidemiological aspects of Chikungunya in the State of Rio Grande do Norte during 2019 and 2021.
Methods:
Samples of suspected cases of chikungunya from different municipalities in Rio Grande do Norte were analyzed. A total of 540 samples were tested using the qRT-PCR.
Results:
134 were chikungunya positive in 2019 (n = 82) and 2020 (n = 52), representing a total of 25% for both years. Most of those affected were female (60%) in the age group between 20 and 39 years old. The most frequent health issues associated with infection were fever (65%), headache (48%) and arthralgia (47%). We identified two (2/134) probable cases of congenital infection and two asymptomatic cases (1.5%). The highest mean viral load peak was found on the first day of symptom onset. The highest proportion of cases reported in 2019 was observed in Natal, in the Tirol neighbourhood (57%); and in 2020, in the municipality of Guamaré (33%).
Conclusions:
This study contributes to the Chikungunya population-based surveillance in urban centres of the state of Rio Grande do Norte, outlining higher incidence areas, which will serve as a basis for disease epidemiological control.
Engel Lie rings with chain conditions
Authors: Amayo Ralph
Published: July 2023

A result of Max Zorn states that if a Lie ring satisfies the maximal condition for subrings and if each element is a bounded left Engel element then the Lie ring is nilpotent. The purpose of this paper is to extend this result to Lie rings satisfying the general Engel condition and with no infinite strictly ascending chains of abelian subrings. A similar result was obtained by I. N. Stewart for locally nilpotent Lie algebras.
Brownian motion and sets of multiplicity
Authors: Kaufman Robert
Published: July 2023

$X(t)$ is Brownian motion on the axis $-\infty<t<\infty$, with paths in $R^{n},~n\geqq 2$. $X(t)$ leads to composed mappings $f\circ X$, where $f$ is a real-valued function of class $\Lambda^{\alpha}(R^{n})$, whose gradient never vanishes. To define the class $\Lambda^{\alpha}(R^{n})$, when $\alpha>1$, take the integer $p$ in the interval $\alpha-1\leqq p<\alpha$ and require that $f$ have continuous partial derivatives of orders $1, \cdots, p$ and these fulfill a Lipschitz condition in exponent $\alpha-p$ on each compact set; to specify further that $\mathrm{grad}\,f\neq 0$ throughout $R^{n}$, write $\Lambda_{+}^{\alpha}$. Then a closed set $T$ is a set of ``$\Lambda^{\alpha}$-multiplicity'' if every transform $f(T)\subseteq R^{1}(f\in\Lambda_{+}^{\alpha})$ is a set of strict multiplicity--- an $M_{0}$-set (see below). Henceforth we define $b=\alpha^{-1}$ and take $S$ to be a closed linear set.
A construction o f the idempotent-separating congruences on a bisimple orthodox semigroup
Authors: Donald LaTorre
Published: July 2023

For any bisimple orthodox semigroup $S$ we show how to construct all idempotent-separating congruences on $S$, and give an explicit construction for the quotient semigroup of $S$ modulo such a congruence.
On Rees localiti es and $H_i$-local rings
Authors: Ratliff Louis
Published: July 2023

The main theorem gives a necessary and sufficient condition for each Rees locality $\mathscr{L}=R[tb, u]_{(M,tb,u)}$ of a local ring $(R, M) $ with respect to a principal ideal $bR$ in $R$ to be either an $H_{i}$-ring (that is, for all prime ideals $p$ in $\mathscr{L}$ such that height $p=i$, depth $p=$ altitude $\mathscr{L}-i$) or a homogeneously $H_{i}$-ring (same condition holds for homogeneous $p$). Numerous corollaries follow concerning the cases: $R$ is complete; $R$ is Henselian; and, $\mathscr{L}$ is $H_i$, for all $i\geqq 0$. A generalization to ideals generated by more than one element is given, and we relate the results to two of the chain conjectures on prime ideals.
Substantiation of the optimal mining sequence of an ore deposit under conditions of high stress and low rock mass strength
Authors: Balek Aleksand
Published: July 2023

Introduction. When choosing the mining sequences of an ore deposit, technological and organizational factors are mostly taken into account. However, when using systems with caving which involve considerable mined-out spaces, the geomechanical factor, which determines stability of mine workings, plays a determining role. The research objective is to reveal the dependence between the stability of the development and face-entry headings within the mined-out space influence zone and the excavation sequence of the isolated ore block under conditions of high stress and low ore and rock mass strength. Methods of research. Numerical modeling of the enclosing ore and rock mass secondary stressstrain state formation was carried out by the finite element method in the Rocscience RS3 program together with the original FEM software package. Modeling was performed for two variants of block excavation – from the center to the flanks and from one flank to the other along the strike. For the analysis, we proposed a coefficient representing the product of compressive stress concentration zones length by their existence duration. Results. Based on the analysis of the maximum stress concentration areas distribution in the marginal rock mass, as well as the time of their influence, the optimal sequence of actual mining was substantiated according to the factor of influence on bottom workings stress-strain state – from flank to flank along the strike. Conclusions. The obtained result confirms the model representations about the mechanism of rock mass stressed redistribution in the process of lens-shaped deposit excavation. The representations suggest that during mined-out space development along the strike, compressive stresses concentrate at its ends. However, the intensity of end sections expansion in the flank to flank variant is two times as high as in the center to flank variant. The duration of the stress concentration zones impact on the bottom workings is therefore less, which is indicated by the proposed coefficient.
Environmental, social, and WASH factors affecting the recurrence of cholera outbreaks in displacement camps in Northeast Nigeria: a rapid appraisal
Authors: Jaber Tarek , Fame Thiaba , Agho Osas Aizeyosabor , Van de Walle Bartel , Bartram Jamie , Boelee Eline
Published: July 2023

In 2021, Nigeria witnessed a severe cholera outbreak that affected Borno state, in which more than 1,600,000 internally displaced persons (IDPs) resided at the time. This rapid appraisal explored factors that facilitate the recurrence of cholera outbreaks in sites hosting IDPs in Northeast Nigeria. Semi-structured interviews were conducted with water, sanitation, and hygiene (WASH), management, and healthcare personnel working in ten displacement camps in Borno state. The interviews were complemented by transect walks and field observations, measurements of free residual chlorine levels, and publicly available data published by the International Organization for Migration Displacement Tracking Matrix. The recurrence of cholera outbreaks appears to be facilitated by substantial interactions between IDPs and host communities, and suboptimal WASH services in camps. Of particular concern, IDP camps are exposed to extreme weather-related events that damage facilities and subsequently affect WASH practices. WASH services in camps may likewise be severely hindered by an influx of new arrivals. In conclusion, we emphasize the importance of expanding WASH activities to host communities and developing site-specific WASH interventions and chlorination targets. Practical recommendations are needed for the prevention and control of outbreaks following extreme weather-related events and population influxes.
Efficient adsorption of tartrazine from an aqueous solution using a low-cost orange peel powder
Authors: Honorine Amana Tokodne , Daouda Abia , T. Domga , Richard Domga , Guy Bertrand Noumi
Published: July 2023

Orange peel powder was activated using different methods and was used to remove tartrazine (E102) from an aqueous solution. The following three adsorbents were synthethized: orange peel powder activated thermally (POAT), orange peel powder activated with sulfuric acid (POAA), orange peel powder activated with soda (POAS). These adsorbents were then characterized by Fourier Transform Infra-Red Spectrometry (FTIR), Raman spectroscopy, powder X-Ray Diffraction (XRD), and point-of-zero charge. The experimental parameters such as contact time, dose of adsorbent, initial concentration of tartrazine, pH, and temperature were studied. The adsorption capacities of tartrazine for the optimal POAT, POAA, and POAS were found to be 121.74, 122.25, and 116.35 mg/g, respectively. The experimental data were analyzed by Freundlich and Temkin isotherm models, as well as the pseudo-second-order kinetic model.
Improved RUSLE model to simulate the effect of slope forest area on soil and water conservation
Authors: Wang Hui , Bai Yu , Man Xiaojun , Tang Zhiping , Zhang Shaoping
Published: July 2023

The problem of soil and water loss on slope land has always been one of the key issues that people pay attention to. How to reasonably arrange tree species and planting methods can effectively improve the current situation of water loss and soil erosion. The Revised Universal Soil Loss Equation (RUSLE) model is a widely used soil erosion prediction model, but it does not consider the impact of tree height and crown size on soil erosion. In this paper, six experimental plots of soil and water conservation were carried out on the forest slope land in southern China. Six experimental plots were planted with different trees, and all kinds of data were collected for 3 years. On the basis of data analysis and machine learning methods, it is found that tree height and crown have a significant impact on soil erosion, but have no significant impact on runoff formation. With the growth of trees, the amount of soil loss in each plot gradually decreases. At the same time, an improved RUSLE model related to tree height and crown has been established, which has a high simulation effect (R2 of testing reaches 0.6775, R2 of all data reaches 0.5452).
Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin
Authors: Rauf Abdur , Abu-Izneid Tareq , Imran Muhammad , Hemeg Hassan A. , Bashir Kashif , Aljohani Abdullah S.M. , Aljohani Mona S.M. , Alhumaydhi Fahad A. , Khan Ishaq N. , Bin Emran Talha , Gondal Tanweer Aslam , Nath Nikhil , Ahmad Ishtiaque , Thiruvengadam Muthu
Published: July 2023

Flavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), and oxidative stress. Fisetin, derived from fruits and vegetables, suppresses cancer growth by altering cell cycle parameters that lead to cell death and angiogenesis without affecting healthy cells. Clinical trials are needed in humans to prove the effectiveness of this treatment for a wide range of cancers. According to the results of this study, fisetin can be used to prevent and treat a variety of cancers. Despite early detection and treatment advances, cancer is the leading cause of death worldwide. We must take proactive steps to reduce the risk of cancer. The natural flavonoid fisetin has pharmacological properties that suppress cancer growth. This review focuses on the potential drug use of fisetin, which has been extensively explored for its cancer-fighting ability and other pharmacological activities such as diabetes, COVID-19, obesity, allergy, neurological, and bone disorders. Researchers have focused on the molecular function of fisetin. In this review, we have highlighted the biological activities against chronic disorders, including cancer, metabolic illnesses, and degenerative illnesses, of the dietary components of fisetin.
The Gulf Achievement of Cholesterol Targets in Out-Patients Study
(GULF ACTION): Design, Rationale, and Preliminary Results
Authors: Albackr Hanan B , Al Waili Khalid , Almahmeed Wael , Jarallah Mohammad Al , Amin Mohammad I , Alrasadi Khalid , Batais Mohammed A. , Almigbal Turky H. , Youssef Ali , Alghamdi Mohammad , Al Shehri Mohammad , Ahmad Islam , ElToukhy Riham A. , Kholaif Naji , Kinsara Abdulhalim J. , Al-Kindi Manal , Barzargani Nooshin , Hassan Magdy , Suwaidi Shamsa Al , Rajan Rajesh , Altaradi Hani , Alhabib Khalid F
Published: July 2023

Aim:

To assess the current dyslipidemia management in the Arabian Gulf region by describing
the demographics, study design, and preliminary results of out-patients who achieved low-density
lipoprotein cholesterol (LDL-C) goals at the time of the survey.

Background:

The Arabian Gulf population is at high risk for atherosclerotic cardiovascular disease at
younger ages. There is no up-to-date study regarding dyslipidemia management in this region, especially
given the recent guideline-recommended LDL-C targets.

Objective:

Up-to-date comprehensive assessment of the current dyslipidemia management in the Arabian
Gulf region, particularly in view of the recent evidence of the additive beneficial effects of ezetimibe
and proprotein convertase subtilisin/kexin-9 (PCSK-9) inhibitors on LDL-C levels and cardiovascular
outcomes.

Methods:

The Gulf Achievement of Cholesterol Targets in Out-Patients (GULF ACTION) is an ongoing
national observational longitudinal registry of 3000 patients. In this study, adults ≥18 years on lipidlowering
drugs for over three months from out-patients of five Gulf countries were enrolled between
January 2020 and May 2022 with planned six-month and one-year follow-ups.

Results:

Of the 1015 patients enrolled, 71% were male, aged 57.9±12 years. In addition, 68% had atherosclerotic
cardiovascular disease (ASCVD), 25% of these patients achieved the LDL-C target, and
26% of the cohort were treated using combined lipid-lowering drugs, including statins.

Conclusion:

The preliminary results of this cohort revealed that only one-fourth of ASCVD patients
achieved LDL-C targets. Therefore, GULF ACTION shall improve our understanding of current
dyslipidemia management and “guideline gaps” in the Arabian Gulf region.
In Silico Study of the Structural Disruption of 14α-demethylase Induced
by the Binding of Terminalia chebula Constituents
Authors: Rani Nidhi , Singh Randhir , Kumar Praveen , Verma Nitin
Published: July 2023

Background:

Since ancient times, medicinal plants have been in use in medicine and dai-ly life.

Objective:

To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied.

Methods:

The chemical constituents of the plant were evaluated for antifungal potential via Moler-go Virtual Docker against the enzyme 14α-demethylase.

Results:

The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development.

Conclusion:

The study revealed that the plant possessed various constituents with potential antifun-gal properties and low toxicity.
Review on Hydrogel Based Systems and their use in Drug Delivery for
Wound Healing & Wound Management
Authors: Jayswal Meet A. , Ahlawat Priyanka , Patel Ashaben
Published: July 2023

The largest organ of the human body, the skin, shields the body from the outside environment.
Despite having a great capacity for regeneration, major skin abnormalities cannot heal
on their own and must be covered with artificial skin. In recent years, significant advancements
have been achieved in the area of skin tissue engineering to create novel skin replacements. Because
of their porous as well as moisturized polymeric structural composition, hydrogels are one
of the choices with the greatest ability to imitate the natural skin microenvironment. Naturally
derived polymers, synthesized polymers, polymerizable synthetic monomolecules, as well as
mixtures of natural and synthesized polymers, can all be used to create hydrogels. They can be
used to assist in the regeneration as well as repair of the wounded dermis, epidermis or else both
by dressing various wounds permanently or temporarily. Hydrogels possess distinct properties
like lightweight, stretchable, biocompatible, and biodegradable; they have the potential to be incorporated
as flexible solutions for the care of chronic wounds. Additionally, these characteristics
make hydrogels appropriate for use in the pharmaceutical and medical industries. Physical,
chemical, and hybrid bonding are all involved in the creation of hydrogels. Several processes, including
solution casting, solution mixing, bulk crosslinking polymerization, the free radical
mechanism, radiation therapy, and the development of interpenetrating networks, are used to create
the bonding. This review primarily focuses on the type of wounds with phases in wound healing
and the many kinds of hydrogels based on cross-linking, ionic charge, physical properties,
source etc., and it also describes potential fabrication techniques for hydrogel design in biomedical
applications, drug delivery as well as wound management hydrogel systems. Hydrogel-based
systems for wound recovery and management are described, as well as current research & future
prospective of hydrogel-based drug delivery systems in wound healing for topical applications.
A novel approach in the synthesis of CdS/titania nanotubes array nanocomposites to obtain better photocatalyst performance
Authors: Pratiwi Reno , Ibadurrohman Muhammad , Listiani Dewi Eniya , - Slamet
Published: July 2023

Studies that seek to improve the performance of photocatalyst continue to develop. Several observations have been made on the effect of using ultrasonic waves during the synthesis process of CdS/Titania Nanotubes Array (CdS/TiNTA) nanocomposites on an ability to degrade ciprofloxacin solution (CIP) and produce hydrogen. Therefore, the nanocomposite synthesis process uses the Successive Ionic Layer Adsorption and Reaction (SILAR) method, with (CH3COO)2Cd and Na2S as the precursors. During the SILAR process, sonication was applied for 60 minutes and carried out in the amorphous phase of TiO2 to increase the effectiveness of contact between the two semiconductors. The synthesis results were confirmed in term of their crystallinity, morphology, the presence of components on the surface, and the shift of bandgap by means of XRD, FESEM, FTIR, and UV-Vis DRS characterization, respectively. Photocatalytic activities of the nanocomposites were evaluated in a system containing 10 ppm CIP solution, on the purpose of observing their ability to degrade CIP and produce hydrogen. Our findings revealed an improvement in crystallinity, successful semiconductor coupling, and a band gap narrowing in the synthesized nanocomposites. Furthermore, the photocatalysts synthesized in the amorphous TiO2 and by sonication during SILAR offered doubled production capacity of hydrogen (0.191 mmol/m2) as compared to photocatalysts synthesized without sonication (0.092 mmol/m2). Compared to similar photocatalysts synthesized using the SILAR method in the crystalline phase, photocatalysts synthesized in the amorphous phase exhibited four-fold higher hydrogen production (0.044 to 0.191 mmol/m2). This prominent ability of the nanocomposites is related to the success of CdS adhering well to TiO2 surface to form nanocomposites, so that the bandgap energy position of CdS that is strong in the reduction reaction greatly contributes to improve the performance of the resulting photocatalyst, which is very advantageous in terms of its ability in water-splitting reactions.
Effect of microwave and ultrasonic irradiation on the enzymatic hydrolysis of water hyacinth biomass in the presence of surfactants
Authors: Rokhati Nur , Ratnawati  , Prasetyaningrum Aji , Anggraini Widyah , Nugroho Akbar , Novita Nasyriyatul Hana , Andarani Pertiwi , Riyanto Teguh
Published: July 2023

This paper presents the effect of microwave and ultrasound irradiation on the enzymatic hydrolysis of water hyacinth biomass in the presence of surfactants. Prior to hydrolyzing, the water hyacinth was treated utilizing alkali with and without microwave assistance.  It was revealed that the microwave improved the removal of lignin and hemicellulose. The treated water hyacinth biomass was also characterized using Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), and Fourier-Transform Infrared (FT-IR) Spectroscopy. The effect of surfactant and the assistance of microwave and ultrasound were comprehensively studied. Some parameters varied, including stirring speed, surfactant type, concentration, and reaction time. The results indicated that microwave and ultrasound could enhance the reaction rate. Tween 80 here could improve conventional, microwave-assisted, and ultrasound-assisted hydrolysis of water hyacinth biomass. It was found that the ultrasound-assisted hydrolysis was better than that of others. The results of this research can be used as the groundwork for further developing the lignocellulosic biomass hydrolysis process, especially in an advanced enzymatic hydrolysis process.
Fabrication of glutathione-modified gold nanoparticles as 3-chloropropane-1,2-diol sensor
Authors: Faramitha Yora , Barori Fadhlurrahman Rafi , Dimawarnita Firda , Siswanto  , Aqoma Havid , Nugraha Adam F , Ferdiansyah Alfian
Published: July 2023

Refined palm oil products may contain a harmful substance called as 3-monochloropropane-1,2-diol (3-MCPD), which can potentially be carcinogenic if consumed in excess. The determination of 3-MCPD depends on the sophisticated machine and highly skilled technicians but it is time-consuming. A simple method that proposes rapid detection remains a challenge. Hence, this research aims to develop a colorimetric-based rapid detection sensor using gold nanoparticles functionalized with a ligand, glutathione (GSH) to be bound to 3-MCPD. Varied concentrations of GSH were evaluated to obtain stable GSH-AuNPs. The characterization results showed that the composition of the stable GSH-AuNPs has been achieved by 250 µL of 0.02 M GSH addition. A stable GSH-AuNPs was ruby red with surface plasmon resonance (SPR) band at 520 nm and an average nanoparticle size of 30 nm. The indication for detection of 3-MCPD was marked by the decrease in the absorbance intensity. Thus, GSH-AuNPs have potential to be developed for the 3-MCPD sensor application.
Inferring the Target of Self-defeating Humour in Internet Memes: A Pragmatic Analysis
Authors: Mohammed Suhair Safwat , Majeed Awaz Othman
Published: July 2023

Nowadays, people spend hours on social media conversing and sharing information through jokes and references made online. Digital memes are one of the most favourable means of internet communication, which thrives on humour. The main purpose of humour is to entertain and make people laugh. So, to avoid hurting others by joking at the expense of others, many people turn to self-mockery. One type of self-mockery is self-defeating humour in which the speaker targets himself/herself in a “poor me” fashion. By using a mixed approach of qualitative and quantitative analysis, this research investigated how internet users interpret the target of self-defeating humour in memes. This analysis used the relevance theory of Sperber and Wilson (1995). On this account, this research addressed the process of decoding and inferential enrichment, and lexical pragmatic adjustment. It is said that making oneself the target of a joke is safer and less sensitive than targeting other people. After analysing the inferences of 100 netizens that were drawn from five self-defeating memes, it has been concluded that targeting oneself could be as sensitive as targeting others.
Online Visibility and Scientific Relevance of Strabismus Research: Bibliometric Analysis (Preprint)
Authors: Stupnicki Aleksander , Suresh Basil , Jain Saurabh
Published: July 2023

BACKGROUND

Quality and accuracy of online scientific data are crucial, given that the internet and social media serve nowadays as primary sources of medical knowledge.

OBJECTIVE

This study aims to analyze the relationship between scientific relevance and online visibility of strabismus research to answer the following questions: (1) Are the most popular strabismus papers scientifically relevant? (2) Are the most high-impact strabismus studies shared enough online?

METHODS

The Altmetric Attention Score (AAS) was used as a proxy for online visibility, whereas citations and the journal’s impact factor (IF) served as a metric for scientific relevance. Using “strabismus” as a keyword, 100 papers with the highest AAS and 100 papers with the highest number of citations were identified. Statistical analyses, including the Spearman rank test, linear regression, and factor analysis, were performed to assess the relationship between AAS, citations, a journal’s IF, and mentions across 18 individual Web 2.0 platforms.

RESULTS

A weak, positive, statistically significant correlation was observed between normalized AAS and normalized citations (P<.001; r=0.27) for papers with high visibility. Only Twitter mentions and Mendeley readers correlated significantly with normalized citations (P=.02 and P<.001, respectively) and IF (P=.04 and P=.009, respectively), with Twitter being the strongest significant predictor of citation numbers (r=0.53). For high-impact papers, no correlation was found between normalized citations and normalized AAS (P=.12) or the IF of the journal (P=.55).

CONCLUSIONS

While clinical relevance influences online attention, most high-impact research related to strabismus is not sufficiently shared on the web. Therefore, researchers should make a greater effort to share high-impact papers related to strabismus on online media platforms to improve accessibility and quality of evidence-based knowledge for patients.
Effects of yoga on impulsivity in patients with and without mental disorders: a systematic review and meta-analysis of randomized clinical trials (Preprint)
Authors: Machado Yuri de Castro , Oliveira Mariana de Jesus , Lima Jogiely Larissa Ferreira , Barghav Hermant , Varambally Shivarama , Miranda Débora Marques de , Romano-Silva Marco Aurélio
Published: July 2023

BACKGROUND

Yoga can be used as a complementary intervention to conventional treatments, whether pharmacological or non-pharmacological. Sustained practice of yoga can generate a series of benefits for individuals' quality of life and improve their physical fitness.

OBJECTIVE

To investigate the potential effects of yoga as an adjunct intervention in conditions involving impulse control issues, such as attention deficit hyperactivity disorder (ADHD), borderline personality disorder, bipolar affective disorder, and substance use disorders.

METHODS

We performed a systematic review and meta-analysis of placebo-controlled, randomized trials of yoga in patients with impulsivity. PubMed, Web of Science, and Science Direct databases were searched for trials published up to January, 2023. Data were extracted from published reports and quality assessment was performed per Cochrane recommendations. The effect size was determined using unbiased Hedges' g with 95% confidence intervals (CIs) to assess different measurements of impulsivity.

RESULTS

Out of 277 database results, 6 RCT were included in systematic review and 4, in meta-analysis. To assess the level of attention and impulsiveness, the following scales were analyzed: Barratt Impulsiveness, UPPS-P Impulsive Behavior scale, Conners’ Continuous Performance Test IIª and Conners’ Parent Rating Scale–Revised: Long. There was no significant effect in effect sizes from four studies on the effects of yoga on impulsivity didn’t show a significant effect (g = -0.06; 95% CI, -0.37–0.24; p = 0.69).

CONCLUSIONS

Yoga didn’t have a significant improvement in impulsivity when compared to placebo. There are many tools to assess impulsivity, but they mean different concepts and domains consisting in a weakness on comparison of yoga effects.
Glucocorticoids for the treatment of IgA nephropathy: pros and cons. Research data and own experience
Authors: Chub O.I.
Published: July 2023

IgA nephropathy is the most common pattern of primary glomerular diseases worldwide and remains a leading cause of chronic kidney disease and kidney failure. The incidence of IgA nephropathy is 2.5 per 100,000 population per year. Presentation ranges from isolated haematuria to significant proteinuria, acute kidney injury and even chronic kidney disease. The 10-year risk of progression to end stage kidney disease or halving of GFR is 26 %. The basis of management of IgA nephropathy is goal-directed supportive care in the form of rigorous blood pressure control, use of renin-angiotensin system blockers in the maximum tolerated dose, and a focus on life-style modification that includes smoking cessation, weight management, and restriction of sodium intake. Ho­wever, supportive therapy does not always achieve its goals and cannot affect the autoimmune pathogenesis of the disease, while the role of immunosuppressants and systemic glucocorticoids remains controversial. This review presents an analysis of clinical trials and our own experience regarding the role of steroids and supportive therapy in the treatment of IgA nephropathy.
Organization of the specialized medical care in conditions of limited resources (military status) (on the example of the provision of nephrology aid in Ukraine)
Authors: Ivanov D.D.
Published: July 2023

The paper considers the features of the provision of pediatric and adult nephrology medical care during martial law in Ukraine from February 2022 to May 2023. The influence of military stages on the nephrology care are presented, territorial zones during the conflict are highlighted, event tracks are shown. Separately, the activity of the Ukrainian Association of Nephrologists/Ukrainian Association of Pediatric Nephrologists, new opportunities for integrating nephrology into the system of medical knowledge are considered. Along with the negative trends, positive results were revealed that made it possible to move forward in the system of specialized medical care, namely an increase in transplant activity, a wider use of “long” treatment regimens with rituximab, and the use of digital kidney biopsy. Statistical data, SWOT analysis at the stages of the military conflict are given, an analysis is presented for refugees who left for the European Union to receive kidney replacement therapy. The enormous role of humanitarian programs for maintaining the structure of nephrological care in Ukraine is emphasized. The accumulated experience is unique and can serve as material for the analysis of similar situations in the world in the future.
Pengaruh Teman Sebaya, Pendidikan Karakter, Keterampilan Belajar, Pemberian Reward Dan Interaksi Sosial Keluarga Terhadap Prestasi Belajar Siswa Kelas VIII Di MTsN 06 Padang
Authors: Mutiara Ica - , Stevani Stevani , Dahen Lovelly Dwinda
Published: July 2023

This study aims to analyze the sampling technique was Proportional Random Sampling with a total sample of 113 students. The results showed that: 1), peers have a significant effect on learning achievement. Where indicated by the coefficient value of 0.336. This coefficient value is significant because the t-count is 3,477 > t-table is 1,65909. 2), character education has a significant effect on learning achievement. Where indicated by the coefficient value of 0.326. This coefficient value is significant because the value of t-count is 3.153 > t-table of 1.65909. 3), learning skills have a significant effect on learning achievement. Where indicated by the coefficient value of 0.180. This coefficient valueis significant because the value of t-count is 2.246 > t-table of 1.65909. 4), giving rewards have a significant effect on learning achievement. Where indicated by the coefficient value of 0.206. This coefficient value is significant because the value of t-count is 2,929 > t-table of 1,65909. 5), social family interactions have a significant effect on learning achievement. Where indicated by the coefficient value of 0.640. This coefficient value is significant because the value of t-count is 5,002 > t-table of 1,65909. 6), character education, learning skills, giving rewards, and social family interaction together have a significant effect on the learning achievement. Where obtained by the value of F-count 142.226 > F-table 2.30 with a significant level of 0.000 <= 0.05. This means that Ha is accepted and H0 is rejectedKeywords: Peers,Character Education, Learning Skills, Giving Rewards, And Social Family Interaction On Student Achievement.
Pengaruh Efikasi Diri, Aktivitas Belajar, Fasilitas Sekolah, Pendidikan Orang Tua dan Teman Sebaya Terhadap Prestasi Belajar Mata Pelajaran Ekonomi Siswa Kelas XI MAN 3 Kota Padang
Authors: Rusnida Belina , Wahyuni Sri , Eprillison Vivina
Published: July 2023

This study aims to analyze the influence of self-efficacy, learning activities, school facilities, education of parents and peers on the learning achievement of Economics subjects of Class XI MAN 3 Students in Padang City. The results of data analysis in this study found that there was an influence of variables of self-efficacy, learning activities, school facilities, the education of parents and peers together on the learning achievement of Economics subjects of class XI MAN 3 Students in Padang City. The results of each variable can be decomposed based on two levels as follows: First, students who do not participate in the detailed extracurricular, namely the probability value of the self-efficacy variable (0.0000), learning activities (0.0017), school facilities (0.0003), parental education (0.0044) and peers (0.0000) affect student learning achievement which can be proven by a probability value smaller than α (0.05). Second, students who take part in extracurricular that can be detailed, namely the probability value of self-efficacy variables (0.0000), learning activities (0.0256), school facilities (0.0041), parents' education (0.0259) and peers (0.0000) affect student learning achievement which can be proven by a probability value smaller than α (0.05).
Pengaruh Penggunaan Metode Talking Stick Dan Kebiasaan Belajar Terhadap Hasil Belajar Siswa Pada Mata Pelajaran Ekonomi Kelas X MAN 3 Kota Padang
Authors: Putri Willy Septiani , Wahyuni Sri , Ronald Jimi
Published: July 2023

This study aims to analyze the Influence of the Use of Talking Stick Methods and Study Habits on the Economic Learning Outcomes of Class X Students in MAN 3 Padang City. Based on the analysis of data it is known that both classes of samples are usually distributed and homogeneous. The results of the hypothesis test through two way ANOVA results are as follows: 1) The first hypothesis obtained a sig value of 0.000, this means that the sig value. less than the value (a= 0.05 (sig.<(a) then thus the H0 accepted Ha rejected, so it can be concluded that the learning outcomes of students taught using the talking stick method are higher than those taught using conventional learning methods (discovery learning). 2) the second hypothesis, obtained the value of the sig. 0.000, this means that the value of the sig. less than the value (a = 0.05 (sig.< (a) then thus H0 accepted Ha rejected, so it can be concluded that students who have good study habits have high learning outcomes than the learning outcomes of students who have poor study habits. 3) the third hypothesis, obtained the value of the sig level. = 0.401, this means that the value of sig. is greater than the value (a = 0.05 (sig. < (a) then thus the H0 rejected Ha accepted, so that there is no interaction of learning models  talking sticks and study habits towards student learning outcomes.
Pengaruh Kepercayaan Diri, Kebiasaan Belajar, Disiplin Belajar, Lingkungan Keluarga Dan Fasilitas Belajar Terhadap Hasil Belajar Siswa Kelas Xi IPS SMAN 1 Bungo
Authors: Wiza Rahmatan Penta , Areva Desi , Wahyuni Sri
Published: July 2023

Tujuan penelitian ini untuk mengetahui (1) pengaruh kepercayaan diri terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo (2) pengaruh kebiasaan belajar siswa terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo (3) pengaruh disiplin belajar terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo (4) pengaruh lingkungan keluarga terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo (5) pengaruh fasilitas belajar terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo (6) pengaruh kepercayaan diri, kebiasaan belajar, disiplin belajar, lingkungan keluarga, dan fasilitas belajar terhadap hasil belajar siswa kelas XI IPS SMAN 1 Bungo Provinsi Jambi.Jenis penelitian yang digunakan adalah penelitian kuantitatif dan asosiatif. Lokasi penelitian di SMAN 1 Bungo Kabupaten Bungo Provinsi Jambi Tahun pelajaran 2022/2023 yang berjumlah 151 orang siswa. Pengambilan sampel menggunakan teknik Stratified random sampling. Instrumen yang digunakan untuk penelitian ini berupa angket tertutup dengan digunakan uji analisis deskriptif, uji analisis induktif dan uji hipotesis dengan uji t dan uji f dengan menggunakan program Eviews dan SPSS.Hasil penelitian menunjukkan bahwa (1) terdapat pengaruh kepercayaan diri (X1) berpengaruh positif dan signifikan terhadap hasil belajar siswa dengan nilai koefisien 0,896. Berdasarkan analisa data untuk variabel kepercayaan diri diperoleh nilai thitungsebesar 3,505 > ttabel sebesar 1,66600 (2) terdapat pengaruh kebiasaan belajar (X2) berpengaruh positif dan signifikan terhadap hasil belajar siswa dengan nilai koefisien 0,369. Berdasarkan analisa data untuk variabel kebiasaan belajar diperoleh nilai thitungsebesar 4,833 > ttabel sebesar 1,66600 (3) terdapat pengaruh disiplin belajar (X3) berpengaruh positif dan signifikan terhadap hasil belajar siswa dengan nilai koefisien 1,280. Berdasarkan analisa data untuk variabel disiplin belajar diperoleh nilai thitungsebesar 3,680 > ttabel sebesar 1,66600 (4) terdapat pengaruh lingkungan keluarga (X4) berpengaruh positif dan signifikan terhadap hasil belajar siswa dengan nilai koefisien 0,538. Berdasarkan analisa data untuk variabel lingkungan keluarga diperoleh nilai thitungsebesar -3,202 > ttabel sebesar 1,66600 (5) terdapat pengaruh fasilitas belajar (X5) berpengaruh positif dan signifikan terhadap hasil belajar siswa dengan nilai koefisien 0,725. Berdasarkan analisa data untuk variabel fasilitas belajar diperoleh nilai thitungsebesar 3,791 > ttabel sebesar 1,66600 (6) terdapat pengaruh kepercayaan diri, kebiasaan belajar, disiplin belajar, lingkungan keluarga dan fasilitas belajar terhadap hasil belajar siswa keseluruhan diperoleh nilai fhitung 19,347 > ftabel 2,34. Kata Kunci: Pengaruh Percaya Diri, Kebiasaan Belajar, Disiplin Belajar, Lingkungan Keluarga Dan Fasilitas Belajar terhadap Hasil Belajar
Pengaruh Disiplin Belajar, Konformitas Teman Sebaya, Kepercayaan Diri, Lingkungan Belajar dan Tekanan Orangtua Terhadap Perilaku Menyontek Siswa Kelas VIII SMP Negeri 25 Padang
Authors: Afrianti Yola , Areva Desi , Sari Putri Meliza
Published: July 2023

This study aims to analyze: 1) the influence of learning discipline on cheating behavior, 2) the effect of self-confidence on cheating behavior, 3) the influence of peer co-operation on cheating behavior, 4) the influence of the learning environment on cheating behavior, 5), the influence of parental pressure on cheating behavior. cheating behavior, 6) the influence of learning discipline, peer conformity, self-confidence, learning environment and parental pressure together influence cheating behavior. The results of this study indicate that: Learning discipline has a significant effect on cheating behavior in class VIII SMP Negeri 25 Padang. Peer conformity has a significant effect on cheating behavior in class VIII SMP Negeri 25 Padang. Self-confidence has a significant effect on cheating behavior in class VIII SMP Negeri 25 Padang. The learning environment has a significant effect on the cheating behavior of class VIII students of SMP Negeri 25 Padang. Parental pressure on cheating behavior of class VIII students of SMP Negeri 25 Padang.
Hippocampus Prosthesis for Memory Impairment
Authors: Chandra Sawarya
Published: July 2023

Abstract: Hippocampus is the area of the brain that is vital for functions as learning, memory and mood setting. It also reacts to injury or neurodegeneration with robust plasticity. Damage to the hippocampus leads to loss of ability to convert short-term memory to new long-term memories. This can happen due to epilepsy, stroke, dimentia or head injuries. Hippocampal injuries typically lead to cognitive dysfunction, depression, and/or epilepsy. Neural stem cell grafting early after injury has promise for preventing neurological deficits. It modulates aberrant hippocampal post-injury plasticity.and adds new inhibitory GABA-ergic interneurons into the hippocampus. Hippocampal memory prosthesis is a Brain Machine Interface (BMI) device developed for restoring or enhancing memory functions. The objective is to restore the long-term memory function in a stimulus-specific manner by using a multi-input, multi-output (MIMO) nonlinear dynamical model which might serve as a boon for patients suffering from Alzheimer’s disease.