bluuebunny/crossref_metadata_2025 huggingface dataset:
The value of contrast-enhanced ultrasound in vascular injury from blunt abdominal trauma in solid organs: Comparison with multidetector computed tomography using angiography as the reference standard
Authors: Lee Jisun , Kim Yook , Yi Kyung Sik , Choi Chi-Hoon , Eom Sang-Yong
Published: July 2023

To evaluate the accuracy of contrast-enhanced ultrasound (CEUS) for assessing vascular injury from blunt abdominal trauma in solid organs using angiography as the reference standard and to compare it with contrast-enhanced multidetector computed tomography (MDCT). Forty-nine patients with 52 blunt abdominal trauma lesions who underwent CEUS, MDCT, and angiography were enrolled in this retrospective study. Injuries included the liver (n = 23), kidney (n = 10), and spleen (n = 19). Vascular injury in solid organs was classified into 3 types: isolated pseudoaneurysm, pseudoaneurysm with low-velocity extravasation, and active bleeding. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of CEUS and MDCT for the detection and classification of vascular injury in solid organs were calculated based on angiography. The receiver operating characteristic curve analysis of each test was performed and compared. Thirty-nine vascular injuries in solid organs were detected and classified into 9 isolated pseudoaneurysms, 9 pseudoaneurysms with low-velocity extravasation, and 21 active bleeding based on angiography as the reference standard. The sensitivity, specificity, PPV, NPV, and accuracy for bleeding detection were 97.44%, 100.00%, 100.00%, 92.86%, and 98.08%, respectively, for CEUS and MDCT. The sensitivity, specificity, PPV, NPV, and accuracy of classification (isolated pseudoaneurysm vs. pseudoaneurysm with low-velocity extravasation or active bleeding) of bleeding were 96.67%, 87.50%, 96.67%, 87.50%, and 94.74%, respectively, for CEUS and 100.00%, 75.00%, 93.75%, 100.00%, and 94.74%, respectively, for MDCT. The area under the receiver operating characteristic curves of CEUS and MDCT for bleeding detection was 0.987, and the area under the receiver operating characteristic curves for CEUS and MDCT bleeding classification were 0.921 and 0.875, respectively. CEUS and MDCT exhibited comparable consistency with angiography for detecting and classifying vascular injury from blunt abdominal trauma in solid organs. Therefore, CEUS may be an accurate and rapid imaging tool to detect bleeding and determine the need for transcatheter arterial embolization. We suggest that CEUS could be considered a first-line approach during the preparation time before MDCT to determine the appropriate management for blunt abdominal trauma.
Neuroendocrine tumors in a patient with multiple endocrine neoplasia type 1 syndrome: A case report and review of the literature
Authors: Deng Jian , Liao Xinyi , Cao Hong
Published: July 2023

Rationale:

Hyperparathyroidism is caused by parathyroid tumors combined with gastroenteropancreatic tumors and pituitary tumors, which is common in patients with multiple endocrine neoplasia 1 syndrome (MEN-1). As its main pathogenic factor involves genetic mutations, it can cause a variety of different clinical symptoms. However, cases with negative genetic testing results and multiple nonfunctional malignant neuroendocrine tumors (NETs) with metastasis are relatively rare.

Patient concerns:

A 33-year-old man was admitted to the hospital for hyperparathyroidism. Imaging examination revealed multiple nodules in the parathyroid gland, pancreas, thymus, and adrenal gland, and multiple metastases to the lung, liver, thoracolumbar, as well as mediastinal lymph nodes.

Diagnoses:

After multidisciplinary consultation, this patient was diagnosed with MEN-1 syndrome with various original tumors and multiple systemic metastases.

Interventions:

The patient underwent parathyroid tumor resection and metastasis biopsy.

Outcomes:

The patient received denosumab and sorafenib treatment.

Lessons:

As an autosomal dominant hereditary disease, MEN-1 patients present with parathyroid hyperplasia, pancreatic and intestinal tumors, pituitary tumors, and so on, which are caused by genetic mutations. These patients would have hyperparathyroidism, hypoglycemia, gastric ulcer, and gastrointestinal diseases. However, some patients with MEN-1 syndrome cannot be diagnosed by genetic testing and simultaneously present with multiple nonfunctional NETs with systemic metastasis. This increases the difficulty of diagnosis and the subsequent treatment.
Comparison between different treatment regimens of vascular targeting drug to malignant pleural effusion in patients with lung cancer: A Bayesian network meta-analysis
Authors: Huang Peng , Guo Zhi-Kai , Xue Zhan-Tu
Published: July 2023

Background:

The presence of malignant pleural effusion in lung cancer patients often suggests a poor prognosis. We plan to investigate which regimen of vascular targeting drug is preferable to control the malignant pleural effusion in such patients.

Methods:

Two investigators dependently searched and screened for randomized controlled trials in PubMed, Embase, Web of Science and China National Knowledge Infrastructure from the database inception to August 2022. R software was applied to build a network model in Bayesian method. Objective response rate of malignant pleural effusion is the primary outcome measure. Besides, the incidence of 3 adverse events were compared, including gastrointestinal reaction, leukopenia and hypertension. Due to the disconnection of network, we analysis and discuss the short-term treatment (3–4 weeks) and long-term treatment (6–12 weeks) respectively.

Results:

31 studies with 2093 patients were identified. Four targeting drugs contain bevacizumab (Bev), anlotinib, apatinib and Endostar. Two administration routes include intracavity perfusion (icp) and intravenous injection. Based on the current evidence, for short-term treatments, compared with single-agent chemotherapy (CT), Bev_icp + CT, anlotinib + CT, Bev_icp and anlotinib + endorstar_icp present better objective response, and no statistical significance was found in objective response between Bev_icp + CT, anlotinib + CT and Bev_icp. For long-term treatments, compared with doublet or triplet chemotherapy (2CT or 3CT), Bev_icp + 2CT, apatinib + 2CT, Bev_icp + 3CT, and Bev_intravenous injection + 2CT are more effective option, but no statistical significance was found in objective response between the 4 combination regimens with chemotherapy.

Conclusion:

Our findings suggest that no statistical significance between above vascular targeting regimens. Pathological type of lung cancer may affect the effect of bevacizumab intracavity infusion plus chemotherapy. The influence of different administration routes of vascular targeting drugs on efficacy remains to be investigated. There are some concerns with the quality of the studies, and some limitations should be considered when interpreting these results, which includes limited geographical region and sample size of studies. Despite these limitations, this study may inform vascular targeting therapy choice in such a patient population.
Identification of target hub genes and construction of a novel miRNA regulatory network in autism spectrum disorder by integrated analysis
Authors: Zhu Jinyi , Meng Haoran , Li Yan
Published: July 2023

The incidence of autism spectrum disorder (ASD) is increasing year by year in children. The aim of the study was to find possible biomarkers for ASD diagnosis as well as examine MicroRNA (miRNA) signatures and crucial pathways. We conducted a two-stage study to explore potential target genes and functional miRNAs. Peripheral blood samples of children with ASD were enrolled and performed RNA sequencing analysis. The overlapped candidate genes were further screened in combination with differentially expressed genes (DEGs) of GSE77103 datasets. STRING established a protein–protein interaction network comprising DEGs. The hub genes were filtered out using the CytoHubba. Then, we set up a miRNA-mRNA regulatory network. Correlational analyses between hub genes and immune cells associated with ASD were carried out using the CIBERSORT software to assess the diversity of immune cell types in ASD. RNA-sequencing analysis was used to confirm the differential expression of 3 hub genes. Briefly, after blood samples were sequenced interrogating 867 differential genes in our internal screening dataset. After screening GEO databases, 551 DEGs obtained from GSE77103. Fourteen common genes were overlapped through DEGs of GEO datasets and internal screening dataset. Among protein–protein interaction network, 10 hub genes with high degree algorithm were screened out and 3 hub genes of them – ADIPOR1, LGALS3, and GZMB – that were thought to be most associated with the emergence of ASD. Then, we developed a network of miRNA-mRNA regulatory interactions by screening miRNAs (such as hsa-miR-20b-5p, hsa-miR-17-5p, and hsa-miR-216b-5p) that were closely associated to 3 hub genes. Additionally, we discovered 18 different immune cell types associated with ASD using the CIBERSORT algorithm, and we discovered that mononuclear macrophages differed considerably between the 2 groups. Overall, 3 hub genes (ADIPOR1, LGALS3, and GZMB) and 15 candidates miRNAs-target 3 genes regulatory pathways representing potentially novel biomarkers of ASD diseases were revealed. These findings could enhance our knowledge of ASD and offer possible therapeutic targets of ASD patients in the future.
Long-term Outcomes of Single and Dual En Bloc Kidney Transplants From Small Pediatric Donors: An ANZDATA Registry Study
Authors: Eastment Jacques G. , Ryan Elizabeth G. , Campbell Scott , Ray Mark , Viecelli Andrea K. , Jegatheesan Dev , Kanagarajah Vijay , Griffin Anthony , Preston John M. , Johnson David W. , Isbel Nicole
Published: July 2023

Background.

Kidney transplants from small pediatric donors are considered marginal and often transplanted as dual grafts. This study aimed to compare long-term outcomes between recipients of single kidney transplants (SKTs) and dual en bloc kidney transplants (EBKTs) from small pediatric donors.

Methods.

Data were obtained from the Australia and New Zealand Dialysis and Transplant Registry. All adult recipients of kidney transplants from donors aged ≤5 y were identified. The primary outcome of interest was death-censored graft survival by donor type. The secondary outcomes were early graft loss, delayed graft function, serum creatinine posttransplantation, acute rejection, and patient survival.

Results.

There were 183 adult recipients of kidney transplants from donors aged ≤5 y old. Of these, 60 patients had EBKT grafts, 79 patients had SKT grafts, and 44 patients had grafts of unknown type. Compared with SKT donors, EBKT donors had lower mean age (P < 0.001) and body weight (P < 0.001). There was no significant difference in death-censored graft survival between the groups, with median survival of 23.8 y (interquartile range 21.2–25) in the EBKT cohort and 21.8 y (11.6–26.8) in the SKT cohort (hazard ratio 1.3; 95% confidence interval, 0.59-2.64; P = 0.56). EBKT grafts had lower acute rejection rates than SKT grafts (P = 0.014). There was no significant difference observed between groups with respect to early graft loss, delayed graft function, posttransplantation serum creatinine posttransplantation, or patient survival.

Conclusions.

EBKT and SKTs from small pediatric donors are associated with excellent long-term graft survival rates.
Static, dynamic and non‐weightbearing ultrasound evaluation of the digital flexor tendon sheath improves sensitivity and specificity of manica flexoria tears diagnosis in cobs and ponies
Authors: Marcatili Marco , Cantatore Federica , Hibner‐Szaltys Maria , Withers Jonathan
Published: July 2023

Background

Ultrasonography (US) is commonly used as a first‐line imaging modality in horses with lameness localised to the digital flexor tendon sheath (DFTS). The reported sensitivity of US for the detection of manica flexoria (MF) tears is low.

Objectives

To report sensitivity (Se), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of US for diagnosing MF tears.

Study design

Prospective observational study.

Methods

Sixty‐seven horses (70 limbs) with lameness localised to the DFTS were enrolled. All the horses underwent a standardised US examination of the DFTS including weightbearing (WB), nonweightbearing (NWB) and dynamic NWB US examination. The presence or absence of a MF tear was recorded. All the horses underwent tenoscopic examination as part of the treatment plan. The US diagnosis was recorded and compared with tenoscopic findings. Sensitivity, Sp, PPV and NPV were calculated.

Results

Cobs and ponies were over‐represented (46/67 horses). Ultrasonographic examination correctly predicted the presence of a MF tear in 34/37 (92%) limbs (true positive). In 31/33 (94%) limbs, the MF was considered normal during US examination and this was confirmed during surgery (true negative). In two of 33 (6%) cases, US led to a false‐positive diagnosis. In three of 37 (8%) cases, US failed to identify the presence of a MF tear (false negative (FN)). In all three cases, the MF was only partially torn. The calculated sensitivity of ultrasonography for the detection of MF tears was 92%, specificity 94%, PPV 94% and NPV 91%. There was no significant difference in the ability of operators to identify MF tears.

Main limitations

Two different operators (both DECVS) performed the ultrasonographic examination. The operator performing the US examination was not blinded to the results of the lameness examination. The tenoscopic examination was performed by the same surgeon who had performed the lameness and ultrasonographic examination.

Conclusions

Ultrasonographic examination of the DFTS is an accurate diagnostic modality to rule in or out the presence of a MF tear. Partial MF tears that do not affect its distal border and/or its attachment onto the SDFT can be challenging to diagnose during US examination.
Prevention of atopic dermatitis in high‐risk neonates via different types of moisturizer application: A randomized, blinded, parallel, three‐group, phase II trial (PAF study)
Authors: Inuzuka Y. , Yamamoto‐Hanada K. , Kobayashi T. , Pak K. , Toyokuni K. , Ogita H. , Miyoshi T. , Ogawa K. , Sago H. , Ohya Y.
Published: July 2023

Background

The effectiveness of moisturizers in preventing infant atopic dermatitis (AD) remains unclear. We previously showed that using 2e moisturizer of commercial moisturizer (Shiseido Japan Co., Ltd.) at least once a day significantly prevented AD in infants as compared with as‐needed petroleum jelly. This trial aimed to determine the effectiveness of twice‐ or once‐daily application of Fam's Baby moisturizer (Fam's Inc.) in preventing AD compared with once‐daily 2e moisturizer.

Methods

This trial was a single‐centre, three‐parallel‐group, assessor‐blinded, superiority, individually randomized, controlled, phase II trial that was conducted from 25 August 2020 to 28 September 2021. We randomly assigned 60 newborns with at least one parent or sibling who has AD to receive Fam's Baby moisturizer twice daily (Group A) or once daily (Group B), or 2e once daily (Group C) in a 1:1:1 ratio until they were 32 weeks old. The primary outcome was the time of AD onset.

Results

Atopic dermatitis was observed in 11/20 (55%), 5/20 (25%) and 10/20 (50%), infants in Groups A, B and C, respectively. Cumulative incidence values for AD according to the Kaplan–Meier method showed that infants in Group B tended to maintain an intact skin for a longer period than those in Group C (median time, not reached [NR] vs. 212 days, log‐rank test, p = 0.064). Cox regression analysis showed that the risk of AD tended to be lower in Group B (hazard ratio with group C as control, 0.36; 95% confidential intervals: 0.12–1.06). No serious adverse events occurred in any of the enrolled infants.

Conclusion

Fam's Baby moisturizer may better prevent AD than 2e. Further large‐scale trials should be performed to confirm the efficacy of Fam's Baby moisturizer in preventing AD in infants.
Displacement-based finite element approach on analysing flexible combined pile–raft foundation in layered soil
Authors: Bhaduri Aniruddha , Choudhury Deepankar
Published: July 2023

The present study proposes a new finite element methodology to analyse the behaviour of flexible combined pile–raft foundation (CPRF) situated in layered soil, in a displacement-based framework. The soil medium is idealised as an advanced elastic Pasternak medium and the piles and raft are modelled as bar and plate element, respectively. The two components of CPRF are analysed simultaneously and displacement compatibility is satisfied at the pile–raft junctions. A number of soil–structure interaction factors, which govern the behaviour of CPRF, are suitably subsumed in the analysis scheme. The proposed method is validated with available analytical and experimental studies. Further parametric studies, investigating the effects of soil layering and raft flexibility on the behaviour of CPRF, are explored. It is observed that the load sharing proportion between the components and the raft deformation pattern depend upon the thickness and position of the soft soil layer in a multilayered soil system. The thickness of the flexible raft plays a pivotal role in determining the behaviour of CPRF, founded in a multilayered soil profile. Thus, this research manifests notable advancement in understanding the behaviour of flexible CPRF in layered soil.
Shotgun Metagenomic Analyses of Microbial Assemblages in the Aquatic Ecosystem of Winam Gulf of Lake Victoria, Kenya Reveals Multiclass Pollution
Authors: Khatiebi Sandra , Kiprotich Kelvin , Onyando Zedekiah , Wekesa Clabe , Chi Celestine N. , Mulambalah Chrispinus , Okoth Patrick
Published: July 2023

Lake Victoria, the second‐largest freshwater lake in the world, provides an important source of food and income, particularly fish for both domestic consumption and for export market. In recent years, Lake Victoria has suffered massive pollution from both industrial and wastewater discharge. Microplastic biomes, pharmaceutical residues, drugs of abuse, heavy metals, agrochemicals, and personal care products are ubiquitous in the aquatic ecosystem of Winam Gulf. These pollutants are known to alter microbial assemblages in aquatic ecosystems with far‐reaching ramification including a calamitous consequence to human health. Indeed, some of these pollutants have been associated with human cancers and antimicrobial resistance. There is a paucity of data on the microbial profiles of this important but heavily polluted aquatic ecosystem. The current study sought to investigate the metagenomic profiles of microbial assemblages in the Winam Gulf ecosystem. Water and sediment samples were collected from several locations within the study sites. Total genomic DNA pooled from all sampling sites was extracted and analyzed by whole‐genome shotgun sequencing. Analyses revealed three major kingdoms: bacteria, archaea and eukaryotes belonging to 3 phyla, 13 classes, 14 families, 9 orders, 14 genera, and 10 species. Proteobacteria, Betaproteobacteria, Comamonadaceae, Burkholdariales, and Arcobacter were the dominated phyla, class, family, order, genera, and species, respectively. The Kyoto Encyclopedia of Genes and Genomes indicated the highest number of genes involved in metabolism. The presence of carbohydrate metabolism genes and enzymes was used to infer organic pollutions from sewage and agricultural runoffs. Similarly, the presence of xylene and nutrotoluene degradation genes and enzyme was used to infer industrial pollution into the lake. Drug metabolism genes lend credence to the possibility of pharmaceutical pollutants in water. Taken together, there is a clear indication of massive pollution. In addition, carbohydrate‐active enzymes were the most abundant and included genes in glycoside hydrolases. Shotgun metagenomic analyses conveyed an understanding of the microbial communities of the massively polluted aquatic ecosystem of Winam Gulf, Lake Vicoria, Kenya. The current study documents the presence of multiclass pollutants in Lake Victoria and reveals information that might be useful for a potential bioremediation strategy using the native microbial communities.
Use of frailty assessment instruments in nephrology populations: a scoping review
Authors: Kennard Alice L. , Rainsford Suzanne , Glasgow Nicholas J. , Talaulikar Girish S.
Published: July 2023

Background

Frailty is a clinical syndrome of accelerated aging associated with adverse outcomes. Frailty is prevalent among patients with chronic kidney disease but is infrequently assessed in clinical settings, due to lack of consensus regarding frailty definitions and diagnostic tools. This study aimed to review the practice of frailty assessment in nephrology populations and evaluate the context and timing of frailty assessment.

Methods

The search included published reports of frailty assessment in patients with chronic kidney disease, undergoing dialysis or in receipt of a kidney transplant, published between January 2000 and November 2021. Medline, CINAHL, Embase, PsychINFO, PubMed and Cochrane Library databases were examined. A total of 164 articles were included for review.

Results

We found that studies were most frequently set within developed nations. Overall, 161 studies were frailty assessments conducted as part of an observational study design, and 3 within an interventional study. Studies favoured assessment of participants with chronic kidney disease (CKD) and transplant candidates. A total of 40 different frailty metrics were used. The most frequently utilised tool was the Fried frailty phenotype. Frailty prevalence varied across populations and research settings from 2.8% among participants with CKD to 82% among patients undergoing haemodialysis. Studies of frailty in conservatively managed populations were infrequent (N = 4). We verified that frailty predicts higher rates of adverse patient outcomes. There is sufficient literature to justify future meta-analyses.

Conclusions

There is increasing recognition of frailty in nephrology populations and the value of assessment in informing prognostication and decision-making during transitions in care. The Fried frailty phenotype is the most frequently utilised assessment, reflecting the feasibility of incorporating objective measures of frailty and vulnerability into nephrology clinical assessment. Further research examining frailty in low and middle income countries as well as first nations people is required. Future work should focus on interventional strategies exploring frailty rehabilitation.
Concentrating solar thermal systems
Authors: Παναγόπουλος-Κοντοσταυλάκης Ορέστης
Published: July 2023

Τα συγϰεντρωτιϰά ϑερμιϰά ηλιαϰά συστήματα χρησιμοποιούνται ευρέως για τη μετατροπή ηλιαϰής ενέργειας σε ϑερμότητα για ϑέρμανση ϰαι ψύξη χώρων, ζεστό νερό χρήσης ϰαι ϑερμότητα για βιομηχανιϰές διεργασίες. Στις σύγχρονες τεχνιϰές μετατροπής της ηλιαϰής σε ϑερμιϰή ενέργεια περιλαμβάνονται τα συστήματα παραϰολούϑησης του ήλιου με παραβολιϰά ϰάτοπτρα ή ϰάτοπτρα Φρενέλ.΄Ομως, υπάρχουν ελάχιστες συσϰευές στο εμπόριο με ενδιάμεση ή μέση ϑερμοϰρασία λειτουργίας (100 − 250 °C). Προϰειμένου να ϰαλυφϑεί αυτό το ϰενό στην αγορά, προτείνεται ϰαι μελετάται ένα ϰαινοτόμο συγϰεντρωτιϰό ϑερμιϰό ηλιαϰό σύστημα. Χαραϰτηριστιϰό της προτεινόμενης συσϰευής είναι η συγϰέντρωση της ηλιαϰής αϰτινοβολίας σε επίπεδο αποδέϰτη μέσω ενός πεδίου ϰαϑρεπτών. Η πρωτότυπη διάταξη σχεδιάστηϰε, ϰατασϰευάστηϰε ϰαι δοϰιμάστηϰε σε πραγματιϰές συνϑήϰες. Στην παρούσα εργασία παρουσιάζονται τα ευρήματα της ϑεωρητιϰής μελέτης μέσω αριϑμητιϰών προσομοιώσεων ϰαϑώς ϰαι τα αποτελέσματα της πειραματιϰής μελέτης της εν λόγω διάταξης.
Совершенствование законодательства в сфере несостоятельности (банкротства) юридических лиц
Authors: Горячев А.В.
Published: July 2023

В настоящей статье рассматриваются основные проблемы нормативного регулирования несостоятельности (банкротства) юридических лиц в России, связанные, в частности, с введением моратория в 2022 году. Автором предлагаются рекомендации по изменению законодательства Российской Федерации в области несостоятельности (банкротства) юридических лиц
Transmisja sprzedażowa na Facebooku jako gatunek internetowy i wspólnototwórczy akt komunikacji oraz rozrywkowe show
Authors: Jarosz Marta
Published: July 2023

W niniejszym artykule podejmuję próbę wskazania wzorca gatunkowego właściwego dla transmisji sprzedażowej. Staram się także usystematyzować sposoby działania nadawców omawianego przekazu, których celem jest optymalizacja sprzedaży. Poszukuję odpowiedzi na pytanie, jakie językowe i pozajęzykowe środki służą do jego budowania? Stawiam tezę, że udział w transmisjach sprzedażowych to dla ich odbiorców nie tylko sposób na robienie zakupów. Często równie ważne jest czerpanie ze wspólnototwórczych i rozrywkowych funkcji przekazu.
Pesantren in the Digital Era: Looking for the Chances and the Challenges
Authors: Muiz Abdul
Published: July 2023

This study aims to review the opportunities and challenges of pesantren in the digital era. As an Islamic educational institution that has survived for centuries, pesantren should adapt to the development of science and technology. Some of the questions that arise include: Do pesantrens have opportunities in the digital era? What are the challenges that must be faced in the digital era, and how do pesantrens negotiate the five pillars of Islamic boarding schools in the digital era? This study is a library research by looking at articles, journals, and scientific books related to Islamic boarding schools and their developments. By using descriptive analysis, this study shows that Islamic boarding schools can survive and adapt to the development of digital life and are able to develop better pesantren values through maximizing the use of technology and digital in teaching and learning activities to reach a wider community in general and become an inspiration for educational institutions domestically and internationally.
MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SISWA SD MELALUI PENDEKATAN OPEN-ENDED
Authors: SITANGGANG ANDRI KRISTIANTO
Published: July 2023

Penelitian ini bertujuan untuk untuk mengetahui perbedaan peningkatan kemampuan pemecahan masalah matematika yang menerapkan pendekatan open-ended dengan pembelajaran biasa pada siswa Kelas VI SD St.Thomas 4 Medan. Populasi dalam penelitian ini adalah seluruh siswa Kelas VI SD St.Thomas 4 Medan Tahun Ajaran 2009/2010. Sampel penelitian adalah seluruh siswa kelas VI, dipilih secara acak dua kelas SD St.Thomas 4 Medan. Kriteria pengujian hipotesisi adalah : Ha diterima jika , dimana diperoleh dari daftar distribusi t dengan dk = () dengan peluang dan taraf nyata  = 0,05. Untuk harga thitung lainnya Ho ditolak. Hasil analisis dari data gain kelas Open-Ended dengan kelas Konvensional dengan menggunakan uji t, diperoleh harga thit = 4,32 harga ttabel = pada dk =78 dan taraf signifikansi a = 0,05 diperoleh ttabel = 1,667, ternyata thit > ttabel maka Ha diterima. Dengan demikian dapat disimpulkan bahwa terdapat perbedaan peningkatan kemampuan pemecahan masalah matematika yang diajar dengan pembelajaran Open-Ended  dengan siswa yang diajar dengan pembelajaran konvensional.   Kata kunci : Open-Ended, pemecahan masalah
EPISTIMOLOGI PENDIDIKAN ISLAM
Authors: Qifari Abudzar Al
Published: July 2023

Islamic education is based on the Qur'an and Sunnah which is designed by considering the concept of science, Islamization of science and the character of science in an Islamic perspective that relies on spiritual strength that has a harmonious relationship between reason and revelation, interdependence of reason with intuition. and related to spiritual values. Episemology of Islamic education like this, becomes the foundation of hope in building a better life for Muslims with a more established and stable Islamic civilization. Epistemology of Islamic education like this emphasizes the totality of experience and reality (empiricism) and recommends many ways to study nature (rationalism), so that knowledge obtained from revelation and reason, from observation and intuition, from tradition and theoretical speculation really prints generations. balance between intellectual, skill, and spiritual as well as morality.
PENGARUH KOMPETENSI LEADERSHIP GURU PENDIDIKAN AGAMA ISLAM TERHADAP KECERDASAN KOMUNIKASI INTERPERSONAL PESERTA DIDIK SMPN 1 ENREKANG
Authors: Mutmainnah Amin Rizqy , Azis Rosmiaty , Yahdi Muhammad
Published: July 2023

This research aims to; 1) Describe the teacher leadership competency of Islamic Education at SMPN 1 Enrekang; 2) Describe the intelligence of interpersonal communication of students at SMPN 1 Enrekang; 3) Describe the influence of Islamic Religious Education teacher leadership competencies on the interpersonal communication intelligence of students at SMPN 1 Enrekang. This type of research is a post-facto quantitative study with a simple linear regression research design. This research was conducted at SMPN 1 Enrekang. The population in this study were 257 students at SMPN 1 Enrekang. While the samples in this study were 57 people using the simple random sampling method. The research instrument used to obtain data is the scale of leadership competence and interpersonal intelligence scale. The data analysis technique used is descriptive statistical analysis and inferential analysis. Based on the results of the descriptive statistical analysis the results of the leadership competency study of Islamic Religious Education teachers at SMPN 1 Enrekang are in the medium category, which is 88.37%, while the results of interpersonal communication intelligence of students at SMPN 1 Enrekang are in the medium category, namely 73.96% . From the calculation results obtained (tcount) = 2.835 while (ttable) = 2.004 for a significance level of 0.05%. Because it is greater than it can be concluded that H0 is rejected and H1 is accepted. This means that there is an influence of Islamic religious education teacher leadership competencies on students' interpersonal communication intelligence at SMPN 1 Enrekang.
CHRISTIAN-ANTHROPOLOGY IDEA OF EDUCATION IN THE HERITAGE OF SENIOR SLAVOPHILS
Authors: Близнецова Ю.С.
Published: July 2023

Посредством герменевтического анализа философско-педагогических воззрений старших славянофилов сформулированы теоретикоконцептуальные положения, характеризующие сущность христианскоантропологической идеи воспитания. В контексте идеала целостной личности мыслителями дано обоснование иерархического устроения человека и примата духовного начала в нем. Целью воспитания в понимании философов является спасение человека, обретение им целостности и подлинной свободы посредством воцерковления.

By means of hermeneutic analysis of the philosophical and pedagogical views of the senior Slavophiles, theoretical and conceptual provisions that characterize the essence of the Christian anthropology idea of education have been formulated. In the context of the ideal of a holistic personality, the thinkers substantiated the hierarchical structure of a person and the primacy of the spiritual principle in him. The goal of education according to philosophers is the salvation of a person, the restoring his integrity and attaining his freedom by means of churching.
Aplicación del método simplex por medio de un programa en C++, para calcular SWU en el proceso de enriquecimiento del combustible nuclear
Authors: Martínez Caballero Eduardo , Ramírez Sánchez José Ramón , Sánchez Miranda Liliana Beatríz , Alcántar Torres Adrián
Published: July 2023

En el proceso de enriquecimiento de los ensambles de combustible nuclear que se emplearon en los reactores nucleares de potencia, se requiere una serie de pasos, que incluye el proceso de conversión del uranio en su forma mineral U3O8 a UF6 gasificado, para posteriormente iniciar el proceso de enriquecimiento y aumentar el contenido del isótopo 235U. La difusión gaseosa es una tecnología utilizada para el proceso de enriquecimiento que consiste en forzar al gas de UF6 a través de una membrana semi-permeable, esto produce una ligera separación entre las moléculas que contienen 235U y las que contienen 238U, la repetición sucesiva de este proceso lleva a enriquecer el uranio hasta el valor deseado, y la medida del esfuerzo (y costo asociado) usado en el proceso de enriquecimiento es la Unidad de Trabajo Separativo (SWU). Optimizar el costo de enriquecer uranio es un proceso complejo en el que entran en juego la cantidad y costo del SWU y de la materia prima de U3O8. En este trabajo, se llevará a cabo un análisis de optimización de enriquecimiento de uranio mediante el uso del Método Simplex, este es el nombre con que se suele describir el enfoque general a la solución de programas lineales utilizando el pivoteo.
Corrosion of Electrical Submersible Pumps (ESP) In South Rumaila Oil Field
Authors: Saleh Talib Abdullah , Sahi Safaa Husain , Mohamed Layla Sideeq
Published: July 2023

Rotating cylinder electrode (RCE) is used . in weight loss technique , the salinity is 200000 p.p.m, temperatures are (30,5060,7080Co) . the velocity of (RCE) are (500,1500,3000 r.p.m). the water cut (30% , 50%). The corrosion rate of carbon steel increase with increasing rotating cylinder velocity. In single phase flow, an increase im rotational velocity from 500 to 1500 r.p.m, the corrosion rate increase from 6.88258 mm/y to 10.11563 mm/y respectively.

   In multiphase flow, an increase in (RCE) from 500 to 1500 r.p.m leads to increase in corrosion rate from 0.786153 to 0.910327 mm/y respectively. Increasing brine concentration leads to increase in corrosion rate at water cut 30%.
Load Effect on Wall Attachment Fluidics Amplifier Performance
Authors: AL-Asadi Ali Abdalmohsin
Published: July 2023

An experimental work has been conducted on wall attachment fluidics amplifiers, one of them to study the effect of output pressure or load on the amplifier performance. The output load has been simulated as a piston connected to the device output and the piston can be loaded accordingly. The results shows that the output volume flow rate increases as the supply pressure increases under different load and the output pressure remains constant as the supply pressure increases under constant load.
Review of «Philosophy of Education. Lectures. Practicum: Educational Edition» by Svitlana Cherepanova
Authors: Radionova Nataliia
Published: July 2023

Review of the educational edition by Svitlana Oleksandrivna Cherepanova, Doctor of Philosophical Sciences, Associate Professor of the Department of Philosophy and Pedagogy, Lviv National Stepan Gzhytsky University of Veterinary Medicine and Biotechnology. – Philosophy of Education. Lectures. Practicum: Educational Edition / For masters of the specialty 011 «Educational Pedagogical Sciences». Lviv: Prostir-M, 2023, 304 p.
Wissen kompakt, Gesellschaftlicher Handlungsdruck – Kohlendioxid-Entnahme aus der Atmosphäre: Dringend benötigt
Authors:   CDRmare
Published: July 2023

Selbst bei ambitionierter Klimapolitik wird die Menschheit in drei Jahrzehnten voraussichtlich noch immer 5 bis 15 Prozent der aktuellen Kohlendioxid-Emissionen freisetzen und die Erderwärmung weiter vorantreiben. Ein Ausweg ist der Ausgleich durch eine gezielte Kohlendioxid-Entnahme und -Speicherung.
The impact of valvular heart disease in patients with chronic coronary syndrome
Authors: Molenaar Mitchel A. , Bouma Berto J. , Coerkamp Casper F. , Man Jelle P. , Išgum Ivana , Verouden Niels J. , Selder Jasper L. , Chamuleau Steven A. J. , Schuuring Mark J.
Published: July 2023

Background

The European Society of Cardiology 2019 Guidelines on chronic coronary syndrome (CCS) recommend echocardiographic measurement of the left ventricular function for risk stratification in all patients with CCS. Whereas CCS and valvular heart disease (VHD) share common pathophysiological pathways and risk factors, data on the impact of VHD in CCS patients are scarce.

Methods

Clinical data including treatment and mortality of patients diagnosed with CCS who underwent comprehensive transthoracic echocardiography (TTE) in two tertiary centers were collected. The outcome was all-cause mortality. Data were analyzed with Kaplan-Meier curves and Cox proportional hazard analysis adjusting for significant covariables and time-dependent treatment.

Results

Between 2014 and 2021 a total of 1,984 patients with CCS (59% men) with a median age of 65 years (interquartile range [IQR] 57–73) underwent comprehensive TTE. Severe VHD was present in 44 patients and moderate VHD in 325 patients. A total of 654 patients (33%) were treated with revascularization, 39 patients (2%) received valve repair or replacement and 299 patients (15%) died during the median follow-up time of 3.5 years (IQR 1.7–5.6). Moderate or severe VHD (hazard ratio = 1.33; 95% CI 1.02–1.72) was significantly associated with mortality risk, independent of LV function and other covariables, as compared to no/mild VHD.

Conclusions

VHD has a significant impact on mortality in patients with CCS additional to LV dysfunction, which emphasizes the need for a comprehensive echocardiographic assessment in these patients.
Effect of neonatal and adult sepsis on inflammation-related diseases in multiple physiological systems: a Mendelian randomization study
Authors: Li Suping , Wang Qian , Tan Xin , Wang Linghua , Gong Jin , Zhang Juan , Wang Weilin , Liu Jiangling
Published: July 2023

Background

Long-term impact of sepsis on whole body systems is not well investigated. The aim of the study was to explore the potential association of neonatal/adult sepsis with several inflammation-related diseases in multiple physiological systems.

Methods

Instrumental variables for neonatal and adult sepsis were collected from the public genome-wide association studies, which must satisfy the correlation, exclusivity and independence assumptions. Mendelian randomization methods (including random-effect inverse-variance weighted, MR-PRESSO, weighted median and MR-Egger) were used to determine the genetic association of neonatal/adult sepsis with asthma, allergy, rheumatoid arthritis, body mass index/obesity, type 1/type 2 diabetes and intelligence/dementia. Sensitivity analyses were conducted to assess heterogeneity and horizontal pleiotropy. The study was performed by TwoSampleMR in R software.

Results

The inverse-variance weighted method reported that neonatal sepsis was related to the decreased level of body mass index (OR = 0.988, 95%CI = 0.980 ~ 0.997, P = 0.007), and adult sepsis was related to the decreased risk of obesity (OR = 0.785, 95%CI = 0.655 ~ 0.940, P = 0.009). These results were supported by the other Mendelian randomization methods. In addition, the study did not find any association of neonatal/adult sepsis with the other inflammation-related diseases. No heterogeneity and horizontal pleiotropy were found using sensitivity analyses.

Conclusion

Sepsis had the potential to reduce the risk of obesity or body mass index level at a genetic level, both in neonates and in adults.
Does sourdough bread provide clinically relevant health benefits?
Authors: D’Amico Vera , Gänzle Michael , Call Lisa , Zwirzitz Benjamin , Grausgruber Heinrich , D’Amico Stefano , Brouns Fred
Published: July 2023

During the last decade, scientific interest in and consumer attention to sourdough fermentation in bread making has increased. On the one hand, this technology may favorably impact product quality, including flavor and shelf-life of bakery products; on the other hand, some cereal components, especially in wheat and rye, which are known to cause adverse reactions in a small subset of the population, can be partially modified or degraded. The latter potentially reduces their harmful effects, but depends strongly on the composition of sourdough microbiota, processing conditions and the resulting acidification. Tolerability, nutritional composition, potential health effects and consumer acceptance of sourdough bread are often suggested to be superior compared to yeast-leavened bread. However, the advantages of sourdough fermentation claimed in many publications rely mostly on data from chemical and in vitro analyzes, which raises questions about the actual impact on human nutrition. This review focuses on grain components, which may cause adverse effects in humans and the effect of sourdough microbiota on their structure, quantity and biological properties. Furthermore, presumed benefits of secondary metabolites and reduction of contaminants are discussed. The benefits claimed deriving from in vitro and in vivo experiments will be evaluated across a broader spectrum in terms of clinically relevant effects on human health. Accordingly, this critical review aims to contribute to a better understanding of the extent to which sourdough bread may result in measurable health benefits in humans.
Effect of replacement therapy (CRRT) and hemodialysis (IHD) on severe acute renal failure
Authors: Zhang Xiangyuan , Yuan Yinfang
Published: July 2023

Hyperkalemia, metabolic acidosis, and acute uremia are the main symptoms in patients with severe acute renal failure (SARF). Its clinical symptoms are obvious, and it is extremely harmful. It needs to take active and effective measures for treatment. CRRT refers to any extracorporeal blood purification treatment technique designed to replace impaired renal function for 24 h or nearly 24 h. Hemodialysis treatment is a treatment process in which the patient’s blood is discharged from the body, passes through the dialysis membrane and dialysis machine, removes excess toxins and water in the body, corrects electrolyte and acid-base disorders, and then returns the blood to the body. In order to explore the efficacy of replacement therapy and hemodialysis in the treatment of severe acute renal failure, the data samples were randomly divided into observation group and control group, who were given conventional treatment, hemodialysis and replacement therapy, respectively. Clinical data show that after replacement therapy and hemodialysis in patients with severe acute renal failure in the observation group, the levels of parathyroid hormone, renin, and quality of life were all improved, with an improvement rate of 9.47%, which has certain promotional value.
Research on the local path planning of an orchard mowing robot based on an elliptic repulsion scope boundary constraint potential field method
Authors: Zhang Wenyu , Zeng Ye , Wang Sifan , Wang Tao , Li Haomin , Fei Ke , Qiu Xinrui , Jiang Runpeng , Li Jun
Published: July 2023

In orchard scenes, the complex terrain environment will affect the operational safety of mowing robots. For this reason, this paper proposes an improved local path planning algorithm for an artificial potential field, which introduces the scope of an elliptic repulsion potential field as the boundary potential field. The potential field function adopts an improved variable polynomial and adds a distance factor, which effectively solves the problems of unreachable targets and local minima. In addition, the scope of the repulsion potential field is changed to an ellipse, and a fruit tree boundary potential field is added, which effectively reduces the environmental potential field complexity, enables the robot to avoid obstacles in advance without crossing the fruit tree boundary, and improves the safety of the robot when working independently. The path length planned by the improved algorithm is 6.78% shorter than that of the traditional artificial potential method, The experimental results show that the path planned using the improved algorithm is shorter, smoother and has good obstacle avoidance ability.
Family function and adolescent altruistic behavior: the multiple mediating effects of self-affirmation and psychological resilience
Authors: Cui Hongbo , Bi Xiaoyan , Zhou Xiaowen , Zhang Weixin , Ma Yankun
Published: July 2023

Introduction

The current study aimed to explore the relationship between family function and adolescent altruistic behavior, as well as the mediating effects of self-affirmation and psychological resilience in this relationship.

Methods

A survey was conducted on 972 high school students in Guangdong Province using the Family APGAR, GHQSense of Adequacy, Chinese version of Connor-Davidson Resilience Scale, and Altruistic Behavior Scale.

Results

Results found that the score of psychological resilience of males was significantly higher than that of females, but the score of altruistic behavior was significantly lower than that of females. Family function had a positive predictive effect on altruistic behavior. Psychological resilience played a mediating role between family function and altruistic behavior. Self-affirmation and psychological resilience played chain mediating roles between family function and altruistic behavior.

Discussion

This study indicated that family care is crucial for the development of adolescent altruistic behavior, and that it can promote the development of altruistic behavior through the enhancement of self-affirmation and psychological resilience.
Designing Teaching Activity
Authors: Zamzami Muhammad Rizal Akbar , Zamzami Muhammad Ana
Published: July 2023

The article discusses the idea of designing teaching approach by using cartoon videos as a tool for teaching vocabulary to young learners, specifically 4th and 5th  grade elementary school students who are typically 10-11 years old. The article emphasizes that in the current modern era, a variety of media have already become a part of our daily lives, particularly for children who watch YouTube, Tiktok, and other ssocial media videos. Consequently, teaching and learning process should adapt with the advancement of technology. Designing teaching vocabulary for young learners by using cartoon videos are suitable since young learners are more open-minded, have developed concrete operational thinking, and are motivated to solve their own learning problems. This article also provides a lesson plan which can be utilized in Classroom Action Research (CAR). Overall, the article believes that using cartoon videos is an effective teaching strategy for young learners because it is engaging, enjoyable, and it helps students to learn more effectively.

 

Keywords: cartoon videos, teaching vocabulary, young learners
Effectiveness in Solving Quadratic Equations by Completing the Squares: With and Without Strategic Intervention Material (WAW SIM)
Authors: - Roy O. Anabo
Published: July 2023

This study showed the effectiveness of solving quadratic equations by completing the square: with and without strategic intervention material (WAW SIM). The purpose of this study is to be able to enhance the skills, knowledge and make lessons more exciting for students to learn. Thirty (30) students were used as experimental and control groups, to identify the effectiveness in solving quadratic equations by completing the square the difference of mean percentage scores of pre-assessment and post-assessment of both groups was used. However, to verify if there is a significant difference between the two groups, the t-test will be performed at a 0.05 level of significance. Based on the conclusion, the variable Without SIM there was a significant difference in performance in their pre-assessment and post-assessment having a slightly higher t-test result of 9.15 than the critical value of 2.045. And it was shown from their Mean Percentage Score (MPS) that the result in post-assessment was slightly higher from 41.7% to 62%. A little increased learning but it is not an effective way of solving quadratic equations by completing the square. While the variable With SIM there was a significant difference in performance in their pre-assessment and post-assessment having a greater t-test result of 23.99 than the critical value of 2.045. And it was shown from their Mean Percentage Score (MPS) that the result in post-assessment was more than doubled from 41.7% to 89% it’s a greater increase in learning and a very effective way of solving quadratic equations by completing the square.