bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of Recommender Systems in Formal Learning. A Systematic Literature Mapping
Authors: Ugarte Nahia , Larrañaga Mikel , Arruarte Ana
Published: April 2022

Recommender Systems provide users with content or products they are interested in. The main purpose of Recommender Systems is to find, among the vast amount of information that is available or advertised on the Internet, content that meets the user’s needs i.e., a product or content that satisfies his or her wishes. These systems are being used more and more in many of the services of our daily lives. In this paper, a systematic mapping review that explores the use of Rec- ommender Systems in formal learning stages is presented. The paper analyzes what kinds of items the Recommender Systems suggest, who the users that receive the recommendations are, what kinds of information the Recommender Systems use to carry out the recommendation process, the algorithms and techniques the Recommender Systems employ and, finally, how the Recommender Systems have been evaluated. The results obtained in the review will make it possible to iden- tify not only the current situation in this field but also some of the challenges that are still to be faced.
La communication chez les plantes : biologie et performativité
Authors: Hiernaux Quentin
Published: April 2022

Cet article analyse la communication végétale entre plantes ou avec d’autres espèces. L’intérêt scientifique récent pour cette question est exposé et le phénomène appréhendé grâce aux ressources de l’écologie, de la physiologie végétale, de l’éthologie et de la philosophie du langage ordinaire. J’interprète ensuite les différences et les analogies qui existent entre le langage humain et la communication végétale grâce aux outils de la théorie des actes de langage d’Austin.
Promesses, limites et ambiguïtés du mot « empathie »
Authors: Tisseron Serge
Published: April 2022

Le mot empathie est apparu au xix e  siècle pour tenter de rendre compte de la capacité de l’être humain de projeter certains de ses contenus mentaux autant sur des êtres animés que sur des objets inanimés. Il a subi ensuite plusieurs restrictions au fur et à mesure de son utilisation par divers auteurs. Récemment, l’engouement pour le mot de compassion, puis pour celui de résonance, ont eu pour effet d’en limiter encore plus la signification en la réduisant à une rencontre purement émotionnelle. Mais, au-delà des querelles de mots qui cachent mal des enjeux de pouvoir, le problème reste le même : rabattre sur la préoccupation individuelle des préoccupations dont l’enjeu est bien souvent collectif.
Entre clinique et savoirs : le pari de la formation des éducateurs spécialisés à l’université
Authors: Ponnou Sébastien
Published: April 2022

L’article soutient la nécessité des références à la clinique et aux savoirs dans la formation des travailleurs sociaux. Partant d’une approche historique du diplôme d’État d’Éducateur Spécialisé, l’auteur dénonce les risques de technocratisation des formations et des pratiques induits par les réformes 2007 et 2018. L’article s’ouvre sur un pari : celui de la formation des éducateurs à l’université, comme possibilité de relance de la dialectique clinique-savoirs et mode de subversion des logiques de compétences à l’œuvre dans les référentiels DE.
Pouvoir hypnotique des imagos et emprise anorexique
Authors: Givre Philippe
Published: April 2022

Sujette à des définitions contrastées, la notion d’imago réclame certaines précisions conceptuelles, afin d’établir sa fonction au cœur de la psyché. C’est le cas notamment pour définir les relations qu’elle entretient avec les représentations internes, comme avec l’identification ou le fantasme. « Objets psychiques » par excellence, les imagos requièrent, pour amender leur dimension archaïque, un caractère apophatique afin de se glisser dans la trame fantasmatique. Un phénomène d’effacement ou d’auto-avalement de l’imago doit donc se concrétiser pour que, là où elle faisait craindre au sujet d’être dévoré, annihilé, phagocyté, l’advenue de ce processus de négativisation de l’imago favorise son propre auto-avalement. À défaut de réussir ce « meurtre », comme on l’observe dans la problématique anorexique, les imagos vont conserver leur pouvoir hypnotique, ce pouvoir étant transposé défensivement par ces mêmes sujets en un phénomène d’emprise sur le corps propre.
Sadisme, emprise et destins libidinaux dans le lien conjugal violent
Authors: Pelladeau Élise
Published: April 2022

Il s’agit d’interroger les coordonnées pulsionnelles des mouvements conjugaux violents dans le cadre d’une psychothérapie psychanalytique en unité de soins en milieu carcéral. Nous posons l’hypothèse d’un lien sadique à l’objet qui trouverait son point de butée au seuil du vacillement de celui-ci. La trajectoire de la violence nous apparaît en plusieurs temps : un temps de mouvements sadiques. S’ensuit un point de bascule qui ouvrirait la voie vers une accumulation économique de la force destructrice versant vers la « folie d’emprise ». Ce mouvement buterait sur la souffrance soudainement imposée au sujet par la menace de la disparition de l’objet. Un quatrième temps serait marqué par des autoreproches aux allures mélancoliques. Ces éléments éclairent une perversion processuelle dans les coordonnées pulsionnelles inversant but et poussée, poussée qui deviendrait un mouvement fétichisé.
La création de l’AUPELF et la conception de l’université post-impériale dans l’espace francophone africain
Authors: Gillabert Matthieu
Published: April 2022

En tant que milieu international constitué de fonctionnaires et de recteurs, l’AUPELF (Association des universités partiellement ou entièrement de langue française) tente de s’arranger avec les inégalités en matière d’enseignement supérieur qui existent entre la « francophonie nordique » et les pays francophones décolonisés. Elle s’appuie sur un ensemble d’idées sur la langue qui légitime une identité commune. Ce métadiscours linguistique permet d’effacer l’ancien rapport colonial. Cet article montre comment l’AUPELF conçoit les relations académiques après les indépendances africaines. Elle fonctionne comme une enceinte où se discutent les manières de pallier les difficultés inhérentes aux inégalités. Ces négociations produisent un savoir oublié, sinon ignoré, qui éclaire cette première phase post-impériale.
Asymptotic behavior of eigenvalues of the Maxwell system in the presence of small changes in the interface of an inclusion
Authors: Khelifi Abdessatar , Saidani Siwar
Published: April 2022

In this paper, we derive rigorously asymptotic formulas for perturbations in the eigenfrequencies of a Maxwell system due to small changes in the interface of a smooth inclusion. Taking advantage of small perturbations, we use a rigorous asymptotic analysis to develop an asymptotic formula for the case where the eigenvalue of the reference problem is simple or multiple. We show that our asymptotic formulas can be expressed in terms of the electric permittivity and the profile function \begin{document}$ h $\end{document} modelling the shape perturbation. We assume that our results are ambitious tools to solve the inverse problem of identifying interface changes (deformations) of inclusions, given eigenvalues measurements.
Flows with ergodic pseudo orbit tracing property
Authors: Lee Manseob
Published: April 2022

In the manuscript, we deal with a type of pseudo orbit tracing property and hyperbolicity about a vector field (or a divergence free vector field). We prove that a vector field (or a divergence free vector field) of a smooth closed manifold $ M $ has the robustly ergodic pseudo orbit tracing property then it does not contain any singularities and it is Anosov. Additionally, there is a dense and open set $ \mathcal{R} $ in the set of $ C^1 $ a vector field (or a divergence free vector field) of a smooth closed manifold $ M $ such that given a vector field (or a divergence free vector field) has the ergodic pseudo orbit tracing property then it does not contain singularities and it is Anosov.
Ticagrelor is more effective than clopidogrel in carrier of nonfunctional CYP2C19 allele who has diabetes and acute coronary syndrome - case report and literature review
Authors: Tekeste Rahel , Garza Gregorio , Han Song , Dong Jianli
Published: April 2022

Clopidogrel is a purinergic receptor P2Y12 (P2RY12)-blocking pro-drug used to inhibit platelet aggregation in patients at risk for major adverse cardiac events (MACE), such as coronary artery disease and stroke. Despite clopidogrel therapy, some patients may still present with recurrent cardiovascular events. One possible cause of recurrence are variants in the cytochrome P450 2C19 (CYP2C19) gene. CYP2C19 is responsible for the metabolism of many drugs including clopidogrel. Recent studies have associated pharmacogenetics testing of CYP2C19 variants to guide clopidogrel therapy with a decreased risk of certain recurrent MACEs. Through a different mechanism, diabetes mellitus (DM) and obesity are also associated with clopidogrel treatment failure. We describe the case of a 64-year-old Caucasian woman with a history of acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI), and DM/obesity, who presented to University of Texas Medical Branch (UTMB) in 2019 with a transient ischemic attack (TIA) while on clopidogrel/aspirin dual anti-platelet therapy. After CYP2C19 genetic testing revealed that she was an intermediate metabolizer with a heterozygous *2 genotype, ticagrelor replaced the clopidogrel treatment regimen. No future MACEs were documented in the two-year patient follow-up. Thus, ACS patients with DM/obesity who have undergone PCI and are intermediate CYP2C19 metabolizers may yield better treatment outcomes if prescribed ticagrelor instead of clopidogrel. Whether this improvement was due to genotype-guided therapy or the differing interactions of clopidogrel/ticagrelor in DM/obese patients is unknown based on available data. Regardless, CYP2C19 genotype-guided treatment of ACS/PCI patients, with consideration of DM/obesity status, may provide effective individualized therapy compared to standard treatment. The inclusion of DM/obesity in this study is clinically relevant because DM/obesity has become a major health issue in the United States and worldwide.
Uncertain theoretical foundations of cultural rights
Authors: Spinner Halev Jeff
Published: April 2022

Will Kymlicka’s Liberalism, Community and Culture attempted to explain why cultural identity was important to people, and how liberal theory could accommodate cultural identity. Kymlicka’s book argued that minority cultures deserve to have certain kinds of rights to help them survive. Cultural membership, he argued, was such an important good that liberal political theory was amiss in overlooking it; it needed to be amended in order to recognize that the self-respect of most people was tied to cultural membership, and that people needed a secure cultural context in which to make choices. Yet the importance of the self-respect argument fades in Kymlicka’s later book Multicultural Citizenship, which gives more emphasis to larger cultural groups that are marked off by language. In this article, I focus on the shift that Kymlicka makes between the two books, arguing that the revisions that Kymlicka made to the argument in Liberalism, Community and Culture were necessary, while making the argument less theoretically satisfying.
Bimal Ghosh, The Global Economic Crisis and the Future of Migration: Issues and Prospects. What will Migration Look Like in 2045?
Authors: Uddin Anas Ansar
Published: April 2022

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Poročilo - Aktivnosti projekta, Napotitev delavcev: izmenjava izkušenj, promocija dobrih praks in izboljšanje dostopa do informacij; Posting of workers sharing experiences, promoting best practices and improving access to information
Authors: Toplak Kristina
Published: April 2022

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Hospitalités théâtrales : l’art à l’épreuve de la crise d’accueil
Authors: Lacombe Sophie
Published: April 2022

Cet article examine le rapport entre esthétique et éthique, sous le prisme du concept d’hospitalité chez Jacques Derrida appliqué aux arts de la scène. Il s’agit d’étudier la façon dont s’engagent, directement ou non, certains artistes de théâtre dans la « crise migratoire » en Europe, déployant des modèles d’hospitalité par l’art. Selon les cas analysés, entre pratiques théâtrales au sein de camps de réfugiés ou spectacles de salles programmés sur ce thème, certaines contradictions s’observent dans la volonté d’allier une expérience artistique à une démarche d’accueil, rappelant le paradoxe derridien qui noue hospitalité et hostilité (« hosti-pitalité »). L’article vise à souligner quelques uns de ces paradoxes dans la perspective future de dissoudre le conflit entre éthique et esthétique et envisager les horizons d’un art théâtral comme lieu d’asile.
La tragédie comme dés/enrégimentation de la violence
Authors: Scalco Diego
Published: April 2022

Le présent article discute la question de la (représentation de la) violence par l’analyse du rapport qui se tisse, chez les Tragiques grecs et chez Romeo Castellucci, entre éthique et esthétique. La logique à l’œuvre dans la tragédie ancienne se retrouve dans la constitution de la cité-état comme dans la philosophie platonico-aristotélicienne du droit et aboutit notamment à la légitimation de certaines formes de violence. Or la tragédiographie de Castellucci subvertit cette logique, pointant ainsi les contradictions inhérentes à toute socialisation où la violence est implicitement admise et explicitement administrée en fonction de principes, sur la base de moyens et en vue de fins prétendument raisonnables.
Global Perspectives in Teacher Preparation
Authors: Uematsu-Ervasti Kiyoko
Published: April 2022

This chapter introduces a theoretical model of preparing globally competent educators based on examining preservice educators' understanding of global perspectives in Finland and Japan. Similarities and differences from educators in both countries signify the importance of recognizing the historical, sociocultural, and educational traditions in preparing globally competent teachers.
Translating Cultural Competence Into Organizational Governance
Authors: Diaz Sherri
Published: April 2022

This chapter analyzes a case study of an extensive metropolitan library system in the United States and discusses the importance of cultural competence for a public organization. It shares the promising practices in translating cultural competence into developing an inclusive environment, democratic leadership, a diverse workforce, and vibrant communities to improve democracy and civic engagement.
Un gruppo poco conosciuto: generalità, raccolta, allevamento e studio degli embiotteri italiani e mediterranei
Authors: Fontana Paolo , Buzzetti Filippo Maria , Stancher Gionata
Published: April 2022

Gli Embioptera sono tra gli ordini di insetti meno studiato e quindi meno conosciuto in Italia. Al fine di stimolare e facilitare nuove ricerche su questi singolari insetti, vengono presentate le generalità sulla loro biologia, le tecniche di raccolta, allevamento e studio e le attuali conoscenze sulla loro presenza in Italia e in Europa. Viene presentata anche una chiave per l’identificazione dei generi e una bibliografia essenziale.
DE NOVO AND THERAPY-RELATED MYELODYSPLASTIC SYNDROMES: ANALOGIES AND DIFFERENCES
Authors: Leone Prof. Giuseppe , Fabiani Emiliano , Voso Maria Teresa
Published: April 2022

The aim of our review has been to give an appropriate idea of analogies and differences between primitive MDS (p-MDS) and t-MDS throughout an accurate reviewing of English peer-reviewed literature focusing on clinical, cytogenetic, epigenetic, and somatic mutation features of these two groups of diseases.
Therapy-related MDS (t-MDS) are classified by WHO together with therapy-related acute myeloid leukemia (t-AML) in the same group, named therapy-related myeloid neoplasm.
However, in clinical practice, the diagnosis of t-MDS is made with the same criteria as for primitive MDS (p-MDS), and the only difference is a previous non-myeloid neoplasm. The prognosis and the consequent therapy can be established following the same criteria as for p-MDS, and the therapy is generally decided using the same criteria. We stress the possible difference in cytogenetics, mutations, and epigenetics to distinguish the two forms. Actually, there is no marker specific for t-MDS either in cytogenetics, epigenetics, or mutations; however, some alterations are also frequent in t-MDS and, in general, they induce a poorer prognosis. So, the high-risk forms in t-MDS are prevalent. The present literature data suggest classifying the t-MDS as a subgroup of MDS and introducing some parameters to evaluate the probability of previous therapy in inducing MDS. An important issue remains the patient’s fitness, which strongly influences the outcome.
Keywords: MDS, t-MDS- Cytogenetics, Mutation, Epigenetics.
THE CLINICAL SIGNIFICANCE OF THE SPECTRUM OF INTERACTIONS OF THE RARE IVS-II-5 G>C (HBB: C.315+5 G>C) VARIATION WITH OTHER Β-THALASSEMIA MUTATIONS IN SOUTHERN CHINA
Authors: Zhou Yali , Liao Guiping , Yin Xiaolin , He Sheng , Wu Yi , Xiao Jian , Geng Zhili , Huang Qiuying , Luo Ganghui , Yang Kun
Published: April 2022

Background: IVS-II-5 G>C (HBB: c.315+5 G>C) is a rare β-thalassemia mutation. However, there is no clear evidence regarding the effect of this defect or co-inheritance of other β-thalassemia mutations on phenotypes.
Methods: The clinical phenotypes associated with compound heterozygosity for the IVS-II-5 G>C mutation with other β-thalassemia mutations, together with the potential effect of the genetic modifiers α-thalassemia were studied in 13 patients. Analyses of red cell indices, hemoglobin component, iron status, and α-globin genes were carried out in 19 heterozygotes.
Results: Next-generation sequencing of 24 undiagnosed patients with thalassemia major (TM) or thalassemia intermedia (TI) identified 13 carriers of the IVS-II-5 G>C mutation. There was a wide spectrum of phenotypic severity in compound heterozygotes and 6 (46.2%) of 13 were transfusion dependent. Analysis of 19 heterozygotes indicated that most were hematologically normal without appreciable microcytosis or hypochromia, and approximately half had normal hemoglobin A2 levels at the same time.
Conclusion: Compound heterozygotes for IVS-II-5 G>C and other severe β-thalassemia mutations are phenotypically severe enough to necessitate appropriate therapy and counseling. Co-inheritance of this nucleotide substitution with other β-thalassemia mutations may account for a considerable portion of the incidence of undiagnosed patients with TI and TM in Guangxi. The IVS-II-5 G>C mutation can pose serious difficulties in screening and counseling.
Keywords: β-thalassemia; IVS-II-5 G>C; genotype; phenotype
ASSOCIATION BETWEEN HEPARIN DOSE AND 6-WEEKS MORTALITY IN PATIENTS WITH COVID-19
Authors: Coutureau Claire , Nguyen Philippe , Hentzien Maxime , Noujaim Peter Joe , Zerbib Sarah , Jolly Damien , Kanagaratnam Lukshe
Published: April 2022

Background and Objectives

Severe forms of SARS-CoV-2 infections are associated with high rates of thromboembolic complications. Professional societies and expert consensus reports have recommended the use of anticoagulants for COVID-19 hospitalized patients. Our study aimed to compare the effect of therapeutic, intermediate and prophylactic doses of heparin on 6-week survival in patients hospitalized for COVID-19.MethodsThe study sample is a French cohort of COVID-19 patients, hospitalized between February 25th and April 30th 2020. Patients were assigned to one of 3 anticoagulation dose groups, based on the maximum dose they received for at least 3 days (prophylactic, intermediate or therapeutic). The main outcome was survival up to 42 days after hospital admission. Multivariate Cox regression models were performed to adjust analyses for confounding factors.

Results

A total of 323 patients were included. The mean age of the study sample was 71.6 ± 15 years and 56.3% were men. Treatment with the intermediate versus prophylactic dose of anticoagulation (HR = 0.50, 95%CI = [0.26 ; 0.99], p = 0.047) and with therapeutic versus prophylactic dose (HR = 0.58 95%CI = [0.34 ; 0.98], p = 0.044) was associated with a significant reduction in 6-week mortality, after adjustment for potential confounding factors. Comparison of therapeutic versus intermediate doses showed no significant difference in survival.

Conclusions

Our results reported a significant positive effect of intermediate and therapeutic doses of heparin, compared with a prophylactic dose, on 6-week survival for hospitalized COVID-19 patients.
Managment of Relapsed/Refractory ALL With Inotuzumab During COVID-19. A Casr Report
Authors: Di Palma Martina , Gentilini Elio , Masucci Chiara , Micozzi Alessandra , Turriziani Ombretta , Mulè Antonino , Foà Robin , Martelli Maurizio , D'Ettorre Gabriella , Capria Saveria , Chiaretti Sabina
Published: April 2022

Management of patients with concomitant acute lymphoblastic leukemia (ALL) and COVID-19 infection is challenging. We describe the clinical history of a 40-year-old male with relapsed B-common ALL who developed Sars-CoV2 prior to treatment initiation with inotuzumab. Since the patient was asymptomatic for COVID-19, the first dose of inotuzumab was administered, followed by remdesivir as prophylaxis. However, a worsening in respiratory findings led to a delay in administering the following doses of inotuzumab. Interestingly, even if the patient did not receive the full inotuzumab cycle, he achieved a complete hematologic remission: furthermore, he spontaneously developed anti-sars-COV2 antibodies. COVID-19 treatment also included convalescent plasma, leading to negativization of the viral load. The patient, after COVID-19 recovery, received a second full cycle of inotuzumab, underwent allogeneic transplantation, and is currently in complete hematologic and molecular remission, in good clinical conditions, five months from allograft.
Keywords: acute lymphoblastic leukemia, COVID-19, inotuzumab, remdesevir, convalescent plasma
Electroacupuncture Relieves Postoperative Cognitive Dysfunction in Elderly Rats via Regulating AMP-activated Protein Kinase Autophagy Signaling
Authors: Niu Cong , Zhu Meihua , Zhang Jiamin , Zhang Chenye , Tian Weiqian
Published: April 2022

Postoperative cognitive dysfunction (POCD) is a common complication after surgery in elderly patients. Electroacupuncture (EA) has been reported to relieve POCD in animal models, but the mechanism remains fully elucidated. The objective of this work was to clarify whether EA could alleviate POCD via regulating autophagy. In this study, aged rats were assigned into 4 groups: control, surgery (rats underwent exploratory laparotomy to induce POCD), EA + S (rats received EA pre-stimulation before surgery), and EA + S + Chloroquine (CQ) (rats were intraperitoneally injected with CQ before EA stimulation and then underwent surgery). The cognitive function of rats was assessed by Morris Water Maze (MWM) test after surgery, and autophagy in hippocampal tissues of rats was evaluated by western blotting and transmission electron microscope. Results indicated that the MWM test revealed that rats showed reduced platform crossing and increased total swimming distance after surgery. However, this impaired spatial memory was improved by EA and EA plus CQ pre-treatment. Besides, the surgery caused an increased expression in LC3II, Beclin-1, AMP-activated protein kinase (AMPK), and p-AMPK in hippocampal tissues of rats, while EA and EA plus CQ pre-treatment also reversed this effect. In addition, the surgery-induced increased amount of autophagic vesicles in hippocampal tissues of rats was reduced by EA and EA plus CQ pre-treatment. In conclusion, EA pre-stimulation could effectively attenuate cognitive impairment in aged rats with POCD via inhibiting AMPK signaling-mediated autophagy.
National Nursing and Midwifery Commission Bill
Authors: Peter Rajini , Sharma Suresh K.
Published: April 2022

The purpose of this article is to summarise the major features of the National Nursing and Midwifery Commission (NNMC) Bill, as well as the opportunities and challenges that the proposed legislation presents. We look forward to improved professional standards, title protection, higher quality education, precise scope of practice guidelines and standardisation of nursing and midwifery registration as the Indian Nursing Council gets replaced by the National Nursing and Midwifery Council. We are hopeful for a rapid start and expansion of advanced nurse practitioner programmes, which will allow for increased participation in the country's health system and the advancement of health-care goals.
Presentation and Severity of COVID-19 Among Cancer Patients
Authors: Matta Shanker , Bajpai Ram , Shekhawat Rekha , Singh Rajesh Kumar
Published: April 2022

Coronavirus disease 2019 (COVID-19) continues to have a serious impact on people, including cancer patients and it was declared a public health emergency of international concern by the World Health Organisation. The present article attempts to review the prevalence, presentation and severity of COVID-19 among confirmed cancer patients from various studies. Cancer patients are vulnerable to COVID-19 and the data suggest that patients with cancer are at an increased risk of death compared to patients without cancer. Majority of patients from various studies presented with fever, cough or shortness of breath. Other symptoms included diarrhoea, nausea and vomiting, ageusia and anosmia. Those who died displayed higher rates of comorbidities compared with those who did not, including cardiovascular disease and hypertension. The risk of death was significantly associated with advancing patient age. Mortality from COVID-19 in cancer patients appears to be principally driven by age, gender and comorbidities.
The Prevalence of Cumulative Alloimmunization in Patients with Sickle Cell Disease at King Fahad University Hospital
Authors: AlDawood Rabab Ahmad
Published: April 2022

BACKGROUND:

Sickle cell disease (SCD) is caused by a mutation in the beta-globin gene. Red blood cell (RBC) transfusion is considered the mainstay of management. On the other hand, it carries many side effects, of which alloimmunization is the most significant.

AIMS AND OBJECTIVES:

The aim of this study is to identify the prevalence of alloimmunization among SCD patients and its relation with other independent risk factors in order to provide recommendations for the care of SCD patients.

MATERIALS AND METHODS:

This is a retrospective cohort study conducted at King Fahad Hospital of the University in Al-Khobar from January 1, 2010, to December 31, 2018. Data were collected from both the QuadraMed electronic system and the blood bank transfusion cards. Data were analyzed using IBM SPSS (version 23.0, Chicago, IL, USA).

RESULTS:

One hundred and seven out of 556 SCD patients developed alloantibodies with a prevalence of (19.2%). Anti-E was the most identified alloantibody in 37 (34.6%) patients, followed by anti-K in 33 (30.8%) of the alloimmunized SCD patients. We found a clinically significant correlation between the alloimmunization and age and direct antiglobulin test positivity.

CONCLUSION:

Alloimmunization is a major complication among SCD patients. Moreover, most of the formed alloantibodies were directed toward the Rh and K antigens. All SCD patients should undergo extended RBC phenotyping at the earliest opportunity, including the following RBC antigens (C/c, E/e, K, Jka/Jkb, Fya/Fyb, M/N, and S/s) at a minimum either serologically or by genotyping.
Relationship between Genotype Variants and the Age of First Acute Splenic Sequestration in Patients with Sickle Cell Disease in a Tertiary Center of Saudi Arabia
Authors: Baitalmal Lobna Abdulaziz , Al Kasim Fawaz Abdulaziz , Ghareeb Eatidal Fathey , Azmet Fauzia Rehman , Jaganathan Parameaswari Parthasarathy
Published: April 2022

BACKGROUND:

Acute splenic sequestration crisis (ASSC) is one of the earliest life-threatening complications of sickle cell disease (SCD). Here, we aimed to identify the relation between the age of the first splenic sequestration episode and SCD variants. Episodes of acute splenic sequestration before 1 year of age are associated with a higher risk of recurrence.

METHODS:

We carried out a retrospective chart review study from the medical charts of SCD patients ≤12 years admitted to the Department of Pediatric Hematology King Saud Medical City, Riyadh with the first episode of ASSC and no other complications from January 2014 to December 2019.

RESULTS:

We included 47 patients (46.8% males, 53.2% females) diagnosed with SCD and having experienced their first ASSC in this review. The mean age of the patients at which the first episode of splenic sequestration happened was 3.26 years. The genotype distribution in the population was 74.5% HBSS, 21.3% HBS β0 thalassemia, and 4.3% HBSβ+ thalassemia. The crisis precipitated with fever in 74.5% of patients. Treatment included programmed blood transfusion (46.2%), splenectomy (29.8%). The recurrence rate after the first episode of ASSC was 59.6%. The high rate of recurrence was mainly due to the early age of presentation and poor compliance with suggested treatment. The use of hydroxyurea in 19.1% of patients showed a decrease of recurrence of ASSSC by 66.6% of patients.

CONCLUSION:

The study concluded that the HBSS variant of SCD had the earliest presentation with the first episode of ASSC but the differences were numerical without any statistical difference. Earlier age of presentation is associated with a higher rate of recurrence, but the difference was numerical not statistically significant. Our study shows hydroxyurea decreased recurrent splenic sequestrations; further research would help in establishing its role
Electronic Web-Based Colonoscopy Guidelines
Authors: Kong Joseph , Low David , Wardill David , Stupart Douglas , Guest Glenn , Watters David
Published: April 2022

Background and Objectives:

There is an increasing demand for colonoscopy which tends to exceed service provision. To ensure appropriate referral for colonoscopy, the National Health and Medical Research Council (NHMRC) have developed comprehensive, evidence-based guidelines addressing screening and colonoscopy surveillance. However, some reports suggest that compliance with the guidelines is variable. This study was conducted to determine the compliance rates in our institution and to drive improved adherence to the national guidelines.

Patients and Methods:

This is a retrospective, observational study of all colonoscopies performed from July 2007 to June 2011. A decision support tool was specifically designed and made available via the World Wide Web. To assess the impact of the decision support tool, we measured compliance rates prospectively in January 2011 and January 2013.

Results:

Over the two periods of pre- and post-intervention, there were 103 and 98 patients referred to waiting lists for colonoscopy. Following introduction of the web-based decision support tool, the national colonoscopy guidelines compliance rate increased from 70.5% (103/146) to 87.5% (98/112). Critically, all patients who required colonoscopy surveillance had been appropriately listed excluding four patients (2.4%) who were missed before introducing the web-bed decision guide.

Conclusion:

Using currently available technology, a web-based colonoscopy decision support tool that can generate recommendations according to the NHMRC colonoscopy guidelines was created. This improved the decision-making regarding the need for and timing of diagnostic, screening, or colonoscopy surveillance.
Combatir la desinformación con alfabetización mediática: análisis de las tendencias en la Unión Europea
Authors: Sádaba Charo , Salaverría Ramón
Published: April 2022

Introducción: La desinformación se ha convertido en un problema clave para las sociedades democráticas contemporáneas. Para contrarrestar esta amenaza, las autoridades públicas de numerosos países han puesto en marcha diversas iniciativas legales, tecnológicas y educativas. Este artículo aporta una revisión bibliográfica y de textos legales, que evidencia la importancia creciente otorgada por la Unión Europea a la alfabetización mediática. Metodología: Mediante revisión documental, se examinan informes y textos legales europeos y de países de la UE, con el fin de evaluar el grado de relevancia que se asigna a la alfabetización mediática para luchar contra la desinformación. Resultados: El análisis comprueba una presencia recurrente de la alfabetización mediática como una de las medidas necesarias para combatir la desinformación en el territorio europeo. Discusión y conclusiones: Más allá de simples soluciones tecnológicas y legales para combatir la desinformación, se comprueba que la Unión Europea apuesta por co-responsabilizar a la ciudadanía, mediante políticas de promoción de la alfabetización mediática. Se consolida, en definitiva, un modelo de lucha contra la desinformación basado en un conjunto de soluciones multinivel.
A Qualitative Content Analysis of Responses to CDC’s Foodborne Outbreak Messages on Facebook
Authors:   Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30329, USA, Alban Michael
Published: April 2022

The Centers for Disease Control and Prevention (CDC)coordinates investigations of multistate foodborneoutbreaks. To better inform future communication effortswith the public during these outbreaks, we conducted aqualitative content analysis of comments on multistatefoodborne outbreak Facebook posts distributed on theCDC’s Facebook page September to December 2018.The CDC created 27 Facebook posts for nine multistatefoodborne outbreaks (one to eight posts per outbreak),and 2,612 comments were analyzed. The CDC used twoWeb tools to deliver outbreak information: food safetyalerts (FSAs) and investigation notices (INs). Qualitativeanalyses were conducted separately for Facebook postsresulting from FSAs and INs. Using an inductive codingapproach, we identified nine categories of comments:information sharing (e.g., tagging others), actions (e.g.,discarding contaminated food), convictions and beliefs(e.g., food-related preconceived notions), questions(e.g., clarifying outbreak location), emotional responses(e.g., worry), blame (e.g., responsibility for outbreak),food specific (e.g., repackaging ground beef and losing identifying information), promoting another cause (e.g., vaccine hesitancy), and unrelated. No differences were found between FSAs and INs. Facebook users helped further disseminate important outbreak information but identified barriers that prevented them from taking recommended actions. Real-time evaluation of social media during outbreaks provides opportunities to refine messaging and improve communication.
Certesella larai (Amoebozoa: Arcellinida: Hyalospheniformes) a new soil testate amoeba species from the Dominican Republic and Chile challenges the definition of genera Certesella and Porosia
Authors: Bobrov Anatoly , Duckert Clément , Mitchell Edward A. D.
Published: April 2022

Microbial diversity is known to be huge but remains only partly documented. Testate amoebae are a relatively well studied group or free-living protists that build morphologically characteristic shells on which the taxonomy of this group is mainly based. Among testate amoebae, the Hyalospheniformes are especially well documented and are a model group for microbial biogeography. Here we describe a new species of genus Certesella from Sphagnum mosses and forest litter samples collected in the Dominican Republic and Chile. We name this species Certesella larai to honour our esteemed colleague Enrique Lara. This species bears two large pores connected by tube, which are characteristic of the genera Porosia and Certesella. The new species fits best in the latter genus given the presence of a distinct, sometimes denticulated, neck with a bulge that is absent in genus Porosia but occurs in Certesella. Its elongated shape (length/breadth ratio 2.03–2.58) only overlaps with C. certesi, which is distinguishable by the presence of a distinct longitudinal groove in the neck region that is absent from the new species. Interestingly most specimens lacked the internal teeth which are usually present in members of genus Certesella. As such, while the morphology of C. larai strongly suggests a belonging to genus Certesella, molecular analyses are still required to confirm its phylogenetic position, clarify the relationships among all species in genera Porosia and Certesella and the definition and validity of these two genera. The presence of this new species in two rather distant regions – Caribbean and central Chile – suggests it is likely widespread, but possibly rare. However, this perception may be due to a sampling bias in favour of Sphagnum mosses and wet and organic-rich habitats. This illustrates the need for a more systematic sampling effort to document the full and mostly unknown taxonomic diversity of soil protists.
Effect of microfluidic chip technique in sperm selection for recurrent implantation failure
Authors: Acet Ferruh , Emirdar Volkan
Published: April 2022

Abstract

Purpose: The microfluidic chip technique gives a chance to select healthy sperm with less DNA damage. In this study, we aimed to determine the effect of microfluidic techniques on sperm selection in ICSI treatment in patients with recurrent implantation failure.

Methods: We retrospectively collected data of the patients between 2017 and 2021 from a single center. We analyzed 90 unexplained RIF patients, at whom, 45 patients underwent microfluid chip technique, and 45 patients with conventional sperm selection.

Results: Pregnancy rates among the microfluidic chip technique and conventional swim up sperm selection cycles were 36% versus 34%, (p=0,4), clinical pregnancy rates (CPR)  were 33% versus 31% (p=0,3) and live birth rates (LBR) were 26% versus 25% (p =0,4).

Conclusion: Our study showed that the microfluidic technique does not change CPR, and LBR during IVF treatment for couples with recurrent implantation failure.
Antioxidant capacity of Cosmos sulphureus plants grown in the temperate climate
Authors: Andrushchenko Olena , Vergun Olena , Rakhmetov Dzhamal
Published: April 2022

Cosmos sulphureus is an adventitious species for Europe and Ukraine in particular. It originates from Central and South America, where it grows in tropical and subtropical climates. The climatic conditions of Kyiv are characterized as temperate, with an absolute temperature minimum of –32.2 °C, an absolute maximum of +39.9 °C, and average annual rainfall of 649 mm.Plants were analyzed in the flowering phase, divided into inflorescences, leaves, stems, and roots, dried at +35 °C and then extracted with methanol and water. The determination of the antiradical activity was carried out according to a modified method using a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical inhibition reaction. The highest antiradical activity was detected in inflorescences (59.60–81.81 % inhibition) and leaves (79.81–89.12 % inhibition). Stem extracts had an average level of inhibition (19.63–65.93 %), and root extracts showed only 2.54–39.46 % inhibition. Correlation analysis showed a strong relationship between leaves and stems (r = 0.84), leaves and roots (r = 0.81), and stems and roots (r = 0.91).Extracts of C. sulphureus plants grown in temperate climate were found having a high antioxidant potential but lower than that reported for tropical and subtropical regions. It was found that higher intensity of coloration of marginal florets of the capitulum does not correlate with a higher antiradical activity. Methanolic and water extracts of inflorescences of the genotype CSCO-368812 with intensilly colored perianth inhibited only 59.60 % and 71.50 % of radicals, while similar extracts of the genotype CS-361294 with lighter florets inhibited 71.17 % and 81.81 % of radicals, respectively. Instead, there was a difference in antiradical activity depending on applied extractant. Methanolic extracts of vegetative organs (leaves, stems, roots) prevail over water extracts in terms of their antiradical activity. However, water extracts of inflorescences of both genotypes demonstrated higher level of antiradical activity.
COVID-19 SALGININDA 3B YAZICILARLA GELİŞTİRİLEN ÜRÜNLERİN İNCELENMESİ
Authors: KARDAŞ Cansu , BÖRKLÜ Hüseyin Rıza
Published: April 2022

COVID-19 virüsü; 31 Aralık 2019'da Çin'in Hubei Eyaletinde ortaya çıkan, ateş, öksürük ve nefes darlığı olarak klinik belirtiler gösteren bir solunum hastalığı olarak belirlenmiştir. Bu hastalığın yayılması ile Dünya Sağlık Örgütü (DSÖ) tarafından kısa sürede pandemi ilan edilmiştir. Bu sebeple salgına karşı koruyucu ürünlere olan ihtiyaçlar olağanüstü seviyede artış göstermiştir. Temel koruyucu ürünlere, üretim kapasitesinin çok üstünde gelen talebi karşılamada fabrikalar yetersiz kalmıştır. Bu eksikliği giderebilmek için 3B yazıcı teknolojisi devreye sokulmuştur. 3B yazıcılar sayesinde kısa sürede örgütlenilerek başta sağlık çalışanlarının eksiklikleri giderilmiştir. Siperlik, maske ve aparatları gibi birçok ürün yüzlerce insan tarafından geliştirilmiş ve geliştirilmeye devam edilmektedir. Bu çalışmada pandemi sürecinde bu virüsten korunma amaçlı geliştirilen ürünler ve kullanılan eklemeli imalat teknolojileri incelenmiştir.
Movimentos de integração de tecnologias digitais em tempos de pandemia: diálogos com professores que ensinam Matemática
Authors: Pereira Stelamara Souza , Scherer Suely
Published: April 2022

Este artigo tem como objetivo analisar movimentos de integração de tecnologias digitais ao currículo de Matemática de um grupo de professores do Ensino Fundamental em um processo de formação continuada, a partir de ações realizadas durante o período da pandemia, em aulas remotas. A pesquisa utilizou-se do modelo Formação, Ação e Reflexão — F@R. A análise é apresentada em formato de narrativa, para contextualizar os diálogos realizados com os professores durante a formação. Os resultados evidenciaram que o processo de integração foi vivenciado a partir da (des)construção de modos de uso das tecnologias digitais para o ensino. Dessa forma, é essencial que os professores estejam em constante formação e dispostos a dialogar e refletir sobre suas práticas pedagógicas.
Sensörinöral İşitme Kayıplarında Kümeleme Analizi ile Odyogram Konfigürasyonları
Authors: KEPEKÇİ Ahmet Hamdi , KARATAŞ Betül
Published: April 2022

Amaç: Bu çalışmanın amacı sensörinöral işitme kaybı olan yetişkin hastalarda kümelenme analizi ile odyogram konfigürasyonlarının yaygınlığını araştırmaktır.
Gereç ve Yöntem: Çalışmamıza özel bir hastanenin KBB polikliniğine işitme kaybı ile başvuran ve saf ses odyometrisi sonucunda sensörinöral tipte işitme kaybı olan 97 yetişkin hasta dahil edildi. Çalışmaya dahil edilen hastaların sağ kulak hava iletim eşikleri esas alındı ve odyolojik veriler aynı cihaz ve aynı odyometrist tarafından ölçüldü. Saf ses işitme eşiklerine göre konfigürasyon türleri kategorize edildi.
Bulgular: İncelenen 97 yetişkinin sağ kulak odyometri verileri küme analizi yapıldığında, 7 farklı konfigürasyon tipi bulundu. En sık görülen konfigürasyon slopping %35. 05 olarak bulundu. Bunu sırasıyla diğer, flat, ski-slope, notched, rising, corner tip konfigürasyonlu odyogramlar izledi.
Tartışma ve Sonuç: Çalışmada sensörinöral işitme kaybı olan yetişkinler arasında kabul edilen 7 farklı konfigürasyon arasında en yaygın konfigürasyon tipinin ‘slopping’ olduğu görülmektedir. Klinik yararlılık açısından, işitme cihazı üreticilerinin konfigürasyon tipi seçeneğini işitme cihazı seçim programına eklemeleri önemli bir katkı olabilir.
Productivity costs associated to voice symptoms, low sleep quality, and stress among college professors during homeworking in times of COVID-19 Pandemic
Authors: Atará-Piraquive Ángela Patricia , Rute Sanabria Bibiana Omaira , Cantor-Cutiva Lady Catherine
Published: April 2022

Objective. To estimate the productivity reduction costs associated to self-reported voice symptoms, low sleep quality, and high stress levels among college professors during homeworking in times of COVID-19 pandemic.
Methods. This cross-sectional study included fifty-eight college professors who reported their reduction in productivity at work due to self-perceived stress levels, sleep quality, and voice symptoms.
Results. High stress levels were reported by 24% of the participants, whereas 19% reported voice symptoms, and 3% low sleep quality. Costs associated with the three conditions were calculated for twenty-nine subjects. Productivity costs associated with high stress levels were higher (COP$32.345.925) than those for voice symptoms (COP$1.872.703) and low sleep quality (COP$319.733).
Conclusion: Productivity reduction costs were higher for professors who reported high levels of stress followed by participants with self-reported voice symptoms and low sleep quality, which highlight the importance of prioritizing activities to reduce stress levels and voice symptoms in workplace health promotion programs implemented in educational settings.
Modelo de respuesta a siniestros y su impacto en los indicadores financieros en compañías de seguros en Cuenca, periodo 2017-2020
Authors: Chinchilima Quezada Yolanda Michelle , Lanche Capa María Gabriela , Ordóñez Parra Janice
Published: April 2022

En la actualidad las compañías de seguros se basan en modelos de respuesta para los siniestros, herramienta que verifica el estado en tiempo real de los contratiempos de sus asegurados, forzando a las compañías a mejorar procesos, directrices y atención al cliente. El objetivo de este artículo es establecer pautas y estrategias que ayuden al actual modelo de recepción de siniestros y brindar una pronta respuesta y solución a los mismos, mediante indicadores financieros de los años 2017-2020. Para este propósito se utilizó un enfoque: cuantitativo, descriptivo, explicativo y longitudinal; con ayuda de estados de situación financiera de la Compañía “Seguros Alianza” para sugerir aspectos a perfeccionar, de esta manera sentar un precedente para las diferentes compañías de Seguros; los resultados manifestaron la importancia de una mejora continua en los procesos, renovando su percepción en la sociedad, debido a la capacidad de generar beneficios, reflejados mediante el indicador de liquidez el cual presentó un resultado del 0,18 demostrando que sus activos líquidos cubrieron sus obligaciones a corto plazo, con respecto al indicador de solvencia se obtuvo 1,6 evidenciando la capacidad para satisfacer sus compromisos de pago, en cuanto al Roe refleja un 92,25% para los periodos estudiados, lo que significa que puede cubrir sus pasivos y ser base fundamental para una correcta toma de decisiones por los directivos, como para su análisis de viabilidad de la inversión, por lo cual se propone un modelo estándar para el manejo y respuesta adecuada de los siniestros para las diferentes compañías de seguros.