bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis
Authors: Rastegari Kimiya , Mokhtari-Dizaji Manijhe , Harirchian Mohammad Hossein , Hashemi Hassan , Ayoobi Yazdi Niloofar , Saberi Hazhir
Published: August 2022

Purpose: Investigations of the hemodynamic changes of the venous system in patients with multiple sclerosis (MS) have shown contradictory results. Herein, the biomechanical parameters of the internal jugular vein (IJV) and common carotid artery (CCA) of MS patients were extracted and compared to healthy individuals.Methods: B-mode and Doppler sequential ultrasound images of 64 IJVs and CCAs of women including 22 healthy individuals, 22 relapsing-remitting multiple sclerosis (RRMS) patients, and 20 primary-progressive multiple sclerosis (PPMS) patients were recorded and processed. The biomechanical parameters of the IJV and the CCA walls during three cardiac cycles were calculated.Results: The IJV maximum and minimum pressures were higher in the MS patients than in the healthy subjects, by 31% and 19% in RRMS patients and 39% and 24% in PPMS patients. The venous wall thicknesses in RRMS and PPMS patients were 51% and 60% higher than in healthy subjects, respectively. IJV distensibility in RRMS and PPMS patients was 70% and 75% lower, and compliance was 40% and 59% lower than in healthy subjects. The maximum intima-media thicknesses of the CCAs were 38% and 24%, and the minimum intima-media thicknesses were 27% and 23% higher in RRMS and PPMS patients than in healthy individuals, respectively. The shear modulus of CCA walls in RRMS and PPMS patients was 17% and 31%, and the radial elastic moduli were 47% and 9% higher than in healthy individuals.Conclusion: Some physical and biomechanical parameters of the CCA and IJV showed significant differences between MS patients and healthy individuals.
The role of neutrophils in the pathogenesis of Behcet's disease
Authors: Nurbaeva K. S. , Lisitsyna T. A. , Lila A. M. , Reshetnyak T. M.
Published: August 2022

Behcet's disease (BD) is a systemic vasculitis of unknown etiology, characterized by damage of vessels of any type and caliber, manifested by recurrent ulcerative process in the oral cavity and genital organs, eye damage, joints, gastrointestinal tract, central nervous system and other organs involvement. The pathogenesis of the disease is complex. The contribution of both innate and adaptive immune responses is noted. A feature of BD is hyperactivation of neutrophils and neutrophilic infiltration of affected tissues.The review presents data from studies related to the assessment of the main functions of neutrophils in this disease.
Chronic back pain as a spinal osteoarthritis manifestation: rationale and practice of symptomatic slow acting drugs for osteoarthritis use
Authors: Karateev A. E.
Published: August 2022

Chronic non-specific back pain (CNBP) is the most common pathology of the musculoskeletal system, affecting from 10 to 60% of the adult population in the world, causing severe suffering, disability and a significant deterioration in the quality of life. Osteoarthritis (OA) should be considered as one of the main reasons of the development of CNBP – inflammatory and degenerative changes in the facet and sacroiliac joints, as well as the spinal column itself (in particular, osteitis of the Modic 1 type). Spinal OA is accompanied by biomechanical disturbances, nociplastic (peripheral and central sensitization) and psycho-emotional changes that form a complete picture and various CNBP phenotypes.Recognizing the leading role of OA as the cause of CNBP, it is advisable to use the same therapeutic approaches in this syndrome as in OA of peripheral joints. In particular, it is necessary to consider the use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) in CNBP as the main pathogenetic therapy.Alflutop is one of the most popular parenteral SYSADOA widely used in Russian practice. This drug has a good evidence base: this review presents data from 12 clinical trials of Alflutop in CNBP (n=1479), which confirmed its efficacy and safety.
Pleiotropic effects of diacerein in comorbid patients with osteoarthritis
Authors: Belyaeva I. B. , Mazurov V. I.
Published: August 2022

The article presents an analysis of the therapeutic effect of the drug diacerein (D), which has been used in osteoarthritis (OA) for more than 20 years and is included in the clinical guidelines of the Association of Rheumatologists of Russia (2021) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO, 2019) for the treatment of OA. The main pathogenic effect of D in OA is to suppress the synthesis of interleukin 1, stimulate the production of articular cartilage proteoglycans, and slow down abnormal remodeling of the subchondral bone. The advantages of D in the treatment of patients with OA and comorbidities are presented – a prolonged anti-inflammatory and analgesic effect and good tolerability. These properties of D allow to control the symptoms of OA and improve the quality of life of patients. The structure-modifying effect of D is based on its ability to stimulate the synthesis of articular cartilage proteoglycans with long-term use and prevent abnormal remodeling of the subchondral bone, which leads to a decrease in the risk of OA progression and a delay in total joint arthroplasty. An important advantage of D is its positive metabolic effect in patients with type 2 diabetes mellitus and obesity, which is associated with the ability of D to reduce the level of glycated hemoglobin and body mass index. Data are presented on the absence of adverse cardiovascular effects when using D, which allows us to recommend its use in patients with OA who have comorbid cardiovascular diseases, as well as contraindications for non-steroidal anti-inflammatory drugs.
Papillary Fibroelastoma Incidentally Found on Left Atrial Wall During Minimally Invasive Aortic Valve Replacement
Authors: Al Abri Qasim , El Nihum Lamees I. , Mujeeb Zubair M. , Barrios Roberto , Reardon Michael J. , Ramchandani Mahesh
Published: August 2022

A 60-year-old man was about to undergo minimally invasive aortic valve replacement when transesophageal echocardiography revealed an intracardiac mass on the left atrial free wall. Multimodal images from 5 months earlier had shown no mass. We converted the procedure to open surgery. The excised mass resembled a cardiac myxoma but was determined to be a papillary fibroelastoma. This case illustrates that papillary fibroelastomas can form and grow rapidly, warranting alertness for their unexpected discovery before and during cardiac surgical procedures.
Navigating Islamophobia: the tale of two Polands
Authors: Górak-Sosnowska Katarzyna
Published: August 2022

The paper analyses the Islamophobic and anti-refugee narratives in Poland through the lens of two different modes of patriotism. These two types of patriotism reflect a great division within Polish society – i.e. between openness and aspiration towards EU and closeness and pride from Polish history. Islamophobic and anti-refugee discourse are powerful tools used in contemporary political discourse by the ruling party, yet they exemplify only one of many layers of the division. The paper starts with setting the framework for Islamophobic discourse in Poland, namely lacking post-colonial reflection and cultural homogeneity. It uses the concept of social imaginary to analyse conflicting discourses on Muslims and refugees on three different examples: use of Polish history for as a source of integration vs. defence against allegations; welcoming refugees as European obligation vs. obligation of EU towards Poland, and endorsing multiculturalism vs. Poland as antemurale christianitatis.
Beyond the method change in clinical practice: evaluation of insulin-like growth factor I assay
Authors: Sienes Bailo Paula , Fabre Estremera Marta , Cuenca Alcocel José , César Márquez María Ángeles
Published: August 2022

Objectives

Insulin-like growth factor I (IGF-I) is the preferred biomarker for diagnosing and monitoring growth-related disorders but its serum quantification presents several difficulties since different IGF-I assays still leads to different IGF-I concentrations, especially when results are either above or below the normal range.

Methods

We conducted a prospective study between November and December 2020 at a tertiary University Hospital with 212 serum samples to determine the analytical performance of the IGF-I assay on the Cobas e411 (Roche Diagnostics) and compare it with that of the Immulite 2000XPi (Siemens).

Results

In this work, we report for the first time the existence of discrepancies between IGF-I levels measured by Immulite 2000XPi and Cobas e411. Deming regression model provided a slope of 1.570 (95% CI: 1.395–1.745) and an intercept of −58.591 (95% CI: −89.151 to −28.030), with R2=0.967 and average bias of +53.061 with overestimation of IGF-I. It was found that Cobas e411 provides abnormally high IGF-I concentrations, but further studies are required to elucidate the cause of the discrepancies.

Conclusions

Our data can alert clinicians and laboratory professionals of this situation and avoid misinterpretation of increased IGF-I levels as a therapeutic failure rather than as a problem associated with this method change.
On the generalized growth and approximation of entire solutions of certain elliptic partial differential equation
Authors: Kumar Devendra , Alghamdi Azza M.
Published: August 2022

For an entire function solution of generalized bi-axisymmetric potential equation, we obtain a relationship between the generalized growth characteristics and polynomial approximation errors in sup norm by using the general functions introduced by Seremeta [On the connection between the growth of the maximum modulus of an entire function and the moduli of the coefficients of its power series expansion, Amer. Math. Soc. Transl. 88 (1970), no. 2, 291–301].
Behavior of group piles under combined loadings after improvement of liquefiable soil with nanomaterials
Authors: Huissen Rusal S. , Albusoda Bushra. S.
Published: August 2022

Earthquake-induced liquefaction is prone in a region with loosely saturated sand and higher seismic activity. In recent years, improvement techniques have been used as a pre-construction or retrofitting method for the current construction. Several methods are intended as remedial techniques, which include either densifying the deposit soil, inserting a unique material, or controlling dissipated pore water pressure generated during the seismic motion. The permeation grouting technique is primarily used in remedial liquefaction schemes that aim to improve the soil deposit mainly by cementing the soil particles and filling the void spaces, thereby preventing soil disturbance caused by settlements or distress to an existing foundation or structure. Permeation grouting involves the injection of a low viscosity chemical or particulate grout into the soil pores with little to no change in the soil structure and has been shown to be effective at reducing liquefaction risk beneath existing structures in soils where it is applicable. The mitigation of liquefaction risk by incorporating nanomaterials using the permeation grouting technique, to study the performance of a pile group embedded in the liquefiable treated layer with 1/50 nano-clay and 1/30 nano-SiO2 after 48 h of curing time during the Kobe earthquake, has been adopted. The soil profile treated using nanomaterials showed that the soil stiffness and strength were preserved during shaking because it did not liquefy; simultaneously, the maximum pile bending moments and lateral pile displacements in the treated soil layer were reduced by 30%. Finally, after treatment, the nanomaterials have a significant effect on the reduction of the maximum accelerations in two depths of soil.
II. Calefurnia – eine römische Frau im Sachsenspiegel?
Authors: Holfeld Raphael , Horn Julia-Katharina
Published: August 2022

Calefurnia – a Roman woman in the Sachsenspiegel? Written, oral, and iconographic traditions. The reference to Calefurnia in Sachsenspiegel Landrecht II 63 § 1 has sparked several theories about how Eike came to know the story of the Roman woman Carfania mentioned in D. 3,1,1,5. Did he have access to the Digest? Did he undergo higher education in a monastery? Was he educated in Roman canon law? This article argues that he might have been inspired by a broadly used exemplum of Carfania as a litigious and talkative woman. By pointing out differences between the Digest and an ordo iudiciarius ‘Tractaturi de iudiciis’, it strongly opposes Landau’s thesis about the source of Eike’s knowledge by pointing out resemblances to Val. Max. VIII,3. A Schwabenspiegel manuscript of 1287 adds the interesting detail of Kæfurna showing her bare backside to the emperor. This storyline can also be traced through medieval and early modern literature. Puzzlingly enough, a Dutch Sachsenspiegel manuscript from the 15th century tells yet another version of the story referring to calefurnan ‘breaking wind’. The Sachsenspiegel picture books show Calefurnia with an unidentifiable object in varying shapes that has been interpreted as a depiction of misbehaviour considering the different additions to the story. Overall, the alterations of the anecdote offer a glimpse into the rich tradition surrounding the story of Calefurnia respectively Carfania.
V. Dornröschens Erwachen im Recht der Willensmängel – ein misslungenes Scheingeschäft vor dem Reichsgericht
Authors: Thiessen Jan
Published: August 2022

The Awakening of Sleeping Beauty in an Absence of Intent – a Failed Simulated Transaction in the German Imperial Supreme Court. When the Friedrich Krupp Corporation promised to supply gas to the City of Bochum in 1910, the parties of this long-term contract could not anticipate the scarcity of raw materials during the upcoming First World War. In the aftermath of the war, Krupp was not able to provide for the quality that had initially been stipulated. Nevertheless, the parties prolongated the contract. When the City of Bochum insisted in proper fulfilment, Krupp argued that the prolongation of the contract according to the original conditions had been a simulated transaction the City of Bochum could not insist on. In 1941, the German Imperial Supreme Court denied the applicability of the provisions of the German Civil Code concerning an absence of intent, holding that each and every simulated transaction to be certified within an official document must be considered fraudulent. This article reviews the court’s decision in the light of its ideological background.
Das Gesetzbuch als Botschaft? – für eine andere Gesetzgebungsgeschichte
Authors: Caroni Pio
Published: August 2022

The Code as Message? Call for a Different Legislative History. The contribution examines the history of codification from a new perspective. The focus is not on the perspective of the legislator but rather on the perspective of those subjected to the laws. For, in fact, it is them who decide on the fate of the codification. Thus, a painstaking – and often tedious – history of impact should complete, that is replace the hitherto common and less complex textual history. Only such a history of impact enables more differentiated statements about the fate and importance of the code, for which a few examples are given.
Lint‐O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain
Authors: Yamamoto‐Matsuda Hitomi , Miyoshi Keita , Moritoh Mai , Yoshitane Hikari , Fukada Yoshitaka , Saito Kuniaki , Yamanaka Soichiro , Siomi Mikiko C
Published: August 2022

Loss‐of‐function mutations in Drosophila lethal(3)malignant brain tumor [l(3)mbt] cause ectopic expression of germline genes and brain tumors. Loss of L(3)mbt function in ovarian somatic cells (OSCs) aberrantly activates germ‐specific piRNA amplification and leads to infertility. However, the underlying mechanism remains unclear. Here, ChIP‐seq for L(3)mbt in cultured OSCs and RNA‐seq before and after L(3)mbt depletion shows that L(3)mbt genomic binding is not necessarily linked to gene regulation and that L(3)mbt controls piRNA pathway genes in multiple ways. Lack of known L(3)mbt co‐repressors, such as Lint‐1, has little effect on the levels of piRNA amplifiers. Identification of L(3)mbt interactors in OSCs and subsequent analysis reveals CG2662 as a novel co‐regulator of L(3)mbt, termed “L(3)mbt interactor in OSCs” (Lint‐O). Most of the L(3)mbt‐bound piRNA amplifier genes are also bound by Lint‐O in a similar fashion. Loss of Lint‐O impacts the levels of piRNA amplifiers, similar to the lack of L(3)mbt. The lint‐O‐deficient flies exhibit female sterility and tumorous brains. Thus, L(3)mbt and its novel co‐suppressor Lint‐O cooperate in suppressing target genes to maintain homeostasis in the ovary and brain.
eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior
Authors: Ma Xuanyue , Li Liuren , Li Ziming , Huang Zhengyi , Yang Yaorong , Liu Peng , Guo Daji , Li Yueyao , Wu Tianying , Luo Ruixiang , Xu Junyu , Ye Wen‐Cai , Jiang Bin , Shi Lei
Published: August 2022

Regulation of mRNA translation is essential for brain development and function. Translation elongation factor eEF2 acts as a molecular hub orchestrating various synaptic signals to protein synthesis control and participates in hippocampus‐dependent cognitive functions. However, whether eEF2 regulates other behaviors in different brain regions has been unknown. Here, we construct a line of Eef2 heterozygous (HET) mice, which show a reduction in eEF2 and protein synthesis mainly in excitatory neurons of the prefrontal cortex. The mice also show lower spine density, reduced excitability, and AMPAR‐mediated synaptic transmission in pyramidal neurons of the medial prefrontal cortex (mPFC). While HET mice exhibit normal learning and memory, they show defective social behavior and elevated anxiety. Knockdown of Eef2 in excitatory neurons of the mPFC specifically is sufficient to impair social novelty preference. Either chemogenetic activation of excitatory neurons in the mPFC or mPFC local infusion of the AMPAR potentiator PF‐4778574 corrects the social novelty deficit of HET mice. Collectively, we identify a novel role for eEF2 in promoting prefrontal AMPAR‐mediated synaptic transmission underlying social novelty behavior.
Diverse role of androgen action in human breast cancer
Authors: Takagi Kiyoshi , Yamaguchi Mio , Miyashita Minoru , Sasano Hironobu , Suzuki Takashi
Published: August 2022

Breast cancer is a hormone-dependent cancer, and sex steroids play a pivotal role in breast cancer progression. Estrogens are strongly associated with breast cancers, and the estrogen receptor (estrogen receptor α; ERα) is expressed in 70–80% of human breast carcinoma tissues. Although antiestrogen therapies (endocrine therapies) have significantly improved clinical outcomes in ERα-positive breast cancer patients, some patients experience recurrence after treatment. In addition, patients with breast carcinoma lacking ERα expression do not benefit from endocrine therapy. The androgen receptor (AR) is also expressed in >70% of breast carcinoma tissues. Growing evidence supports this novel therapeutic target for the treatment of triple-negative breast cancers that lack ERα, progesterone receptor, and human EGF receptor 2, and ERα-positive breast cancers, which are resistant to conventional endocrine therapy. However, the clinical significance of AR expression is still controversial and the biological function of androgens in breast cancers is unclear. In this review, we focus on the recent findings concerning androgen action in breast cancers and the contributions of androgens to improved breast cancer therapy.
Termal Olmayan Plazma Uygulamasının Monolitik Zirkonya ile Rezin Siman Arasındaki Makaslama Bağlanma Dayanımına Etkisi
Authors: YILMAZ SAVAŞ Tuba , AKIN Ceyda
Published: August 2022

Amaç: Bu çalışmanın amacı, farklı plazma tipleri (argon ve oksijen), primer ve kumlama uygulamalarının monolitik zirkonya ile self-adeziv rezin siman arasındaki makaslama bağlanma dayanımına etkisinin incelenmesidir.
Gereç ve Yöntemler: Elli adet monolitik zirkonya disk hazırlandı ve sinterlendi. Zirkonya diskler uygulanacak yüzey işlemine göre rastgele beş gruba ayrıldı: Kontrol (herhangi bir yüzey işlemi uygulanmadı), Kumlama (50 μm Al2O3 ile kumlama), Primer (universal seramik primer uygulaması), Oksjen Plazma (10 dakika oksijen plazma uygulaması) ve Argon Plazma (10 dakika argon plazma uygulaması). Örneklere dual-cure bir rezin siman uygulandı ve örneklere 5500 devir termal siklus işlemi yapıldı. Makaslama bağlanma dayanımı testi 1 mm/dak hızında universal bir test cihazında gerçekleştirildi. Veriler tek yönlü ANOVA ve Tukey HSD post-hoc testleri kullanılarak 0.05 anlamlılık düzeyinde analiz edildi.
Bulgular: Gruplar arasındaki ortalama makaslama bağlanma dayanımı değerleri arasında istatistiksel olarak anlamlı fark bulundu (P<0.001). Kumlama ve Primer grupları diğer gruplara kıyasla en yüksek bağlanma dayanımı değerlerini gösterdi ancak aralarında fark bulunmadı (P>0.05). Oksijen ve Argon Plazma grupları Kontrol grubuna göre daha yüksek ancak Kumlama ve Primer gruplarına kıyasla daha düşük bağlanma dayanımı değerleri gösterdi (P<0.001). Plazma grupları arasında anlamlı bir fark bulunmadı (P>0.05).
Sonuç: Plazma uygulaması rezin ile zirkonya arasındaki bağlantıyı arttırmıştır ancak bu artış kumlama ve primer uygulamaları seviyesinde olmamıştır. Primer ve kumlama uygulamaları birbirine alternatif yöntemler olarak kullanılabilir.
ENDODONTİK ACİL DURUMLAR VE TEDAVİ YAKLAŞIMLARI: BİR DERLEME
Authors: ÇİL Aygül , SAĞSEN Burak , ASLAN Tuğrul , ÜSTÜN Yakup
Published: August 2022

Endodontik acil durumlar pulpal ve/veya periapikal dokuların neden olduğu ağrı ve/veya şişlik durumlarıdır. Dental ağrıya genellikle çürük, geniş veya hasarlı restorasyonlar veya travma neden olabilmektedir. Semptomatik irreversible pulpitis, akut apikal periodontitis, akut apikal apse ve travma, hastalarda en sık gözlenen acil durumlardır. Özellikle endodontik acil durumların yönetiminde doğru teşhis, doğru tedavi ve akılcı ilaç kullanımı son derece önemlidir. Sonuç olarak, uygun tedavi, kök kanal tedavisi, apse drenajı ve hatta ağrıdan sorumlu dişin çekimi gibi invaziv yaklaşımlara kadar uzanmaktadır. Bu derlemede endodontik acil durumların hangileri olduğu ve güncel tedavi yaklaşımlarından bahsedilmiştir.
Mineral Trioksit Agregat’a hızlandırıcı eklemek makaslama bağlanma dayanımını etkiler mi?
Authors: MUTLUAY Abidin Talha
Published: August 2022

Amaç: Bu çalışmada, farklı hızlandırıcı ilave edilen Mineral Trioksit Agregat’ın (MTA) kompozite farklı sertleşme sürelerinde makaslama bağlanma dayanımının (MBD) değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: Merkezi boşluklara sahip 120 adet akrilik blok 4 ana gruba ayrıldı. 1. grup (kontrol); sadece MTA, 2, 3 ve 4. grup ise sırasıyla %10 kalsiyum klorür (CaCl2), %23,1 kalsiyum laktat glokonat (CLG) ve %15 disodyum hidrojen fosfat (Na2HPO4) ile karıştırılmış MTA içermektedir. Her grup 2 saat 45 dakika , 24 saat ve 96 saat sertleşme süresine göre 3 alt gruba ayrıldı. Bekleme süreleri tamamlandıktan sonra adeziv sistem (Clearfil SE Bond, Kuraray) ve kompozit rezin (Clearfil Majesty, Kuraray) işlemleri tamamlanan örneklere evrensel test cihazında MBD testi uygulandı. Elde edilen verilerinin karşılaştırmasında, tek yönlü varyans analizi (ANOVA) ve Tukey HSD testleri kullanıldı.
Bulgular: Hızlandırıcısız MTA en yüksek ortalama MBD değeri sergiledi. Hızlandırıcısız MTA, hızlandırıcı olarak CLG ve Na2HPO4 eklenen MTA ile kıyaslandığında aralarındaki fark anlamlı bulundu (p<0.0001). Başlangıç sertleşme süresinde alt gruplar arasında istatistiksel olarak anlamlı farklılık gözlenmedi (p>0,05), diğer sertleşme sürelerinde fark anlamlı bulundu (p<0,05). MTA’ya hızlandırıcı olarak CLG ve Na2HPO4 ilavesinin tüm sürelerde MBD değerlerini azalttığı, CaCl2 ilavesinin ise 96 saatin ardından MBD değerini anlamlı olarak yükselttiği gözlendi.
Sonuç: MTA içerisine hızlandırıcı eklemek MBD değerini düşürmektedir. Ancak MTA’ya hızlandırıcı olarak %10 CaCl2 eklemek 96 saatin ardından yapılacak restoratif işlemlerde pozitif bağlantı sonuçları ortaya çıkarabilir.
Ortodontik Tedavi Sonrası Ektopik Maksiller Kaninlerin Keratinize Dişeti Genişliğindeki Değişim
Authors: KILIÇ Hüseyin Egemen , ACAR Yasemin Bahar
Published: August 2022

Amaç: Vestibülde ve infraoklüzyonda bulunan ektopik kaninlerin ortodontik tedavisi amacıyla birinci premolar çekimi uygulanmış vakalarda, üst kaninlerin keratinize dişeti genişliğindeki değişimleri incelemektir.
Gereç ve Yöntemler: Bu kontrollü klinik çalışmada, üst kanin dişleri vestibülde ektopik bulunan (>2 mm) ve birinci premolar çekimli ortodontik tedavi uygulanmış 50 bireye (ortalama yaş: 18.1 yıl) ait 63 maksiller kanin diş çalışma grubunu oluşturmuştur. Kontrol grubu olarak, çekimsiz ortodontik tedavi uygulanmış ve tedavi sırasında üst kanin dişlerinde klinik olarak belirgin bir dikey hareket olmayan (≤2 mm) 20 bireye (ortalama yaş: 15.8 yıl) ait 20 maksiller kanin diş kullanılmıştır. Tedavi öncesi (T1) ve tedavi sonrası (T2) ağız içi fotoğraflar, geleneksel alçı modeller ve panaromik radyografi kayıtları kullanılmıştır. Ağız içi frontal fotoğraflarda kanin dişin keratinize dişeti genişliği ölçülmüştür. Kanin dişlerin dikey yöndeki yer değişimi sert damak düzlemi referans alınarak panoramik röntgenler üzerinde ölçülmüştür.
Bulgular: Çalışma ve kontrol gruplarında kanin dişin dikey yer değişimi oklüzal yönde ve istatistiksel olarak anlamlı (sırasıyla 3.45 mm, p=0.000; 0.73 mm, p=0.013) bulunurken; keratinize dişeti genişliğinde anlamlı artış (sırasıyla 1.23 mm, p=0.000; 0.25 mm, p=0.016) bulunmuştur. Çalışma grubunda ölçülen değişimler cinsiyet ve yaştan bağımsız (p>0.05) ve kontrol grubuna göre anlamlı olarak daha yüksektir (p=0.000). Dikey yer değişimi ile dişeti genişliğindeki artışın ilişkisi incelendiğinde, dikey hareketin 2-4 mm olduğu örneklemde anlamlı korelasyon bulunamazken (r=0.01); ≥4 mm olduğu örneklemde yüksek korelasyon (r=0.563) bulunmuştur.
Sonuç: Ektopik kaninlerin ortodontik tedavisi sonrasında ağız içinde gerçekleşen klinik dişeti artışını ve bu artışın dikey hareket miktarı ile pozitif yönlü ilişkisini gösteren kontrollü bir klinik çalışma olması sebebiyle sonuçlar anlamlıdır.
Professional Training of Future Masters of Preschool Education for the Formation of Engineering Skills of Preschoolers
Authors: Diachenko Natalia
Published: August 2022

The article is devoted to the theoretical substantiation of the expediency of preparing future masters of preschool education for the formation of engineering skills in preschool children; analysis of scientists’ research on the problem of students’ readiness for pedagogical activity. Some issues of training future masters of preschool education to organize the formation of engineering skills in preschoolers as a necessary component of future professional activity are presented. The readiness of future masters for the formation of engineering skills is interpreted as a special new component in the personality structure, which determines the direction and nature of professional and pedagogical activities, its focus on engineering training of preschool children, consistent actualization in emotional and volitional acts and relevant means of engineering. Innovative ways to improve the professional training of future specialists in the field of preschool education at the second (master's) level are identified, taking into account the formation of competencies defined in the educational and professional training program for masters of specialty 012 Preschool education. Methodical recommendations for future masters of preschool education on the formation of engineering skills in preschool children are given. The essence of engineering thinking is determined as well as the ways of its formation and development in preschool children in the process of relevant activities. LEGO-design and other types of technical creativity are highlighted. The algorithm of formation of engineering skills in children is singled out, which, according to the author, is carried out in stages: "I am a researcher", "I am a designer", "I am a specialist", "I am an artist". The system principles of cooperation of the preschool institution with parents for future masters of preschool education on the formation of engineering skills in preschool children are highlighted.
Influence of Respiratory Exercises on the Functional State of the Cardiovascular System Under Different Physical Activities of Students
Authors: Serman Taras
Published: August 2022

The article stresses that the state of the cardiovascular system determines the level of physical performance. Maintaining the required level of metabolic processes is necessary for efficient mechanisms of energy supply and dynamic work. The researcher proves that activation of respiratory function contributes to such support. Under the influence of systematic breathing exercises in the body develops a set of structural and functional changes aimed at optimizing the functioning of the whole organism and its individual systems. The study involved 35 lyceum students aged 14 years, who were engaged in the developed system for 1.5 years. Each lesson consisted of six parts. In the first, third and fifth parts, they performed exercises with dynamic, and in the second and fourth – with static load. In the first three parts they were combined with breathing exercises with increasing duration of individual phases of breathing, in 4-6 parts – only with deepening of exhalation. The sixth part (relaxation) was performed in a horizontal position. The purpose of the work is to determine the impact of breathing exercises during each part of the lesson on the activity of the cardiovascular system. It has been established that certain features of fatigue and recovery during different types of muscular work in a specific sequence are a reliable physiological basis for improving the health and training effect of physical training in combination with breathing exercises. The results of the experiment on the implementation of our system of health-improving training sessions of respiratory gymnastics prove that changes in work power, nature of muscle contractions and body position during training create conditions for improving adaptive compensatory reactions to different types of loads.
Experimental and numerical studies on the cantilevered leg joint and its reinforced version commonly used in modern wood furniture
Authors: Chen Bingrui , Yu Xiujiao , Hu Wengang
Published: August 2022

The cantilevered leg joint commonly used in modern wood furniture was studied by numerical and experimental methods. A novel joint was proposed and compared with the typical joint commonly used in the cantilevered leg. Both of them were made of beech wood (Fagus orientalis Lipsky). The experimental results showed that the bending moment capacity of the novel joint was remarkably higher than the typical joints, which confirmed that the novel structure had a better mechanical performance. The numerical analysis was conducted according to GB/T 10357.3 standard, the results showed that the stresses of the typical joint were mainly concentrated on the wooden components, while the stresses of the novel joint were concentrated on the metal connectors. The stress concentration obtained by the finite element method (FEM) was consistent with the failure modes of the experimental tests, which provides a reliable method for evaluating and optimizing the novel furniture structure.
Visual Control in Today’s Societies: (Non)Recognition of Faces and Emotions
Authors: Trilupaitytė Skaidra
Published: August 2022

By using a theoretical approach to the critique of surveillance capitalism, and by drawing on public discourse sources on facial recognition (FR) technology, this paper analyzes visual surveillance in contemporary societies. Currently, there are both numerous instances of a sudden development of FR capabilities on a global scale as well as efforts to prevent the development of what is called the “most dangerous technology.” This paper also questions the techno-solutionism that enables “perfect” mathematical human cognition. Overall, the paper sheds light on the global disagreement on the regulatory environment for FR technology, with different countries, states, or big cities treating biometric data protection differently. There is also a confluence of predicaments and legal concerns in the public sphere regarding FR. Nevertheless, it is possible to outline the typical narratives that emerge in media discourses, highlighted in this paper using three different examples. These are (1) concerns about human rights and privacy (the US case), (2) a “soft” indecisiveness about promoting unfettered innovation on the one hand, and preventing human rights abuses on the other (the EU case), and (3) the fear of digital data being collected by a hostile authoritarian state, namely China (the Lithuanian case).
Karl-Otto Apel’s ethics of discourse as the «first philosophy» of the third paradigm
Authors: Yermolenko Anatoliy
Published: August 2022

Based on the concept of the third paradigm of the «first philosophy», the article analyzes the theo- retical and practical philosophy of Karl-Otto Apel. The role of discursive practices as a paradig- matic basis of the philosophy of communication and meta-institutions of all the rest institutions of society is revealed. The author considers the achievements of Ukrainian philosophers in the study of Apel’s heritage, as well as the possibilities of applying Apel’s philosophical theorizing in the study of Ukrainian realities, development of the Ukrainian ethos, and possibility of theo- retical substantiation and practical legitimization of institutions and values. In addition to this, it is also about the relationship between universalist morality and the particular ethos of local worlds, as well as the relationship between the concepts of universalist ethics and global ethos. Using Apel’s methodology, the author of the article argues that the revival of the conventional ethos and the institutional stage of development of moral consciousness does not end the problem of moral development of the Ukrainian nation. The next, no less important, task is the transition to a potentially democratic postconventional morality, which is achieved by communicative ratio- nalization of the world, the creation of institutions of deliberative democracy. The great role and influence of Apel’s philosophy in the world, which is manifested in the fact that there is a kind of communicative international, which unites many supporters of the Apel paradigm in such well known organization as the “Karl-Otto Apel Centro Filosofico Internazionale”, and in such journals as “Topologik”, “Ethik+Diskurs”, etc., which conduct researches based on the Apel paradigm.
Memory discourses and critical scientific history. On the specificity of modern historical discourses
Authors: ZYMOVETS Roman
Published: August 2022

The word «history» can always be understood in two different meanings: as what happened in the past and as a story about the past. One and the same past can be described in different ways. The gap between historical events and representations of these events determines the diversity of historical discourses. Shifting the focus of the philosophy of history from identifying the con- ditions for the possibility of historical knowledge to the analysis of the process of historiography reflects an understanding of the fundamental nature of historical discourses for the formation of pictures of the past. But the fascination with the subject of historical representation often overshadows what makes it possible in principle. Historical discourse is a modern narrative of the past. Thus, the condition for the possibility of historical discursiveness is the mediation of the horizons of the present and the past, which is a fundamental feature of the historicity of human existence. This article explains the discourses of memory and oppositional critical scientific history. Discourses of memory are considered as modern forms of manifestation of the historicity of human existence, because it is in them that the constant mediation of time horizons of the past and present becomes thematic. Critical history declaratively opposes the discourses of memory, but reveals the dependence of its methodological foundations on predetermined forms of under- standing the past presented in memory. The opposition between the discourses of memory and critical history structurally repeats the opposition of tradition and scientific history revealed in hermeneutics. The conceptual shift from tradition to memory reflects the fundamental changes in the modern understanding of historicity associated with the further detraditionalization and globalization of the world. Me- mory appears as a new form of understanding the past, associated with the fear of losing it, as well as understanding the distances and gaps in relation to it. Based on the differentiation of collective memory types, the corresponding types of dis- courses are distinguished. It is argued that historical discourses of identity cannot be identified with historical discourses of power, and historical-didactic and historical-aesthetic discourses are independent forms of modern attitude to the past. In an effort to separate critical reconstruc- tion from memory, scientific discourses become counterfactual to the taken for granted past, represented in the narratives of collective memory.
Epidemiology of Neonatal COVID-19 in the United States
Authors: Devin Joan , Marano Rachel , Mikhael Michel , Feaster William , Sanger Terence , Ehwerhemuepha Louis
Published: August 2022

OBJECTIVES

Data on coronavirus disease 2019 (COVID-19) infections in neonates are limited. We aimed to identify and describe the incidence, presentation, and clinical outcomes of neonatal COVID-19.

METHODS

Over 1 million neonatal encounters at 109 United States health systems, from March 2020 to February 2021, were extracted from the Cerner Real World Database. COVID-19 diagnosis was assessed using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) laboratory tests and diagnosis codes. Incidence of COVID-19 per 100 000 encounters was estimated.

RESULTS

COVID-19 was diagnosed in 918 (0.1%) neonates (91.1 per 100 000 encounters [95% confidence interval 85.3–97.2]). Of these, 71 (7.7%) had severe infection (7 per 100 000 [95% confidence interval 5.5–8.9]). Median time to diagnosis was 14.5 days from birth (interquartile range 3.1–24.2). Common signs of infection were tachypnea and fever. Those with severe infection were more likely to receive respiratory support (50.7% vs 5.2%, P < .001). Severely ill neonates received analgesia (38%), antibiotics (33.8%), anticoagulants (32.4%), corticosteroids (26.8%), remdesivir (2.8%), and COVID-19 convalescent plasma (1.4%). A total of 93.6% neonates were discharged home after care, 1.1% were transferred to another hospital, and discharge disposition was unknown for 5.2%. One neonate (0.1%) with presentation suggestive of multisystem inflammatory syndrome in children died after 11 days of hospitalization.

CONCLUSIONS

Most neonates infected with SARS-CoV-2 were asymptomatic or developed mild illness without need for respiratory support. Some had severe illness requiring treatment of COVID-19 with remdesivir and COVID-19 convalescent plasma. SARS-CoV-2 infection in neonates, though rare, may result in severe disease.
Incongruências na prática jornalística
Authors: Amaral Muriel Emídio Pessoa do , Rocha Paula Melani
Published: August 2022

O artigo discute a ausência na produção jornalística de práticas de inclusão com enfoque em gênero. O recorte do estudo é a invisibilidade de fontes femininas no programa Combate ao coronavírus, exibido pela Rede Globo de Televisão. Foram selecionadas todas as 49 edições e analisou-se as fontes consultadas e citadas diretamente. A discussão fundamenta-se no gênero como perspectiva analítica em interface com os estudos do jornalismo. O artigo percorre a promoção da invisibilidade de fontes de mulheres especialistas e constata que o programa não reconheceu o protagonismo feminino ao não recorrer às mulheres como fontes jornalísticas. A discussão aponta para a prevalência de fontes masculinas especialistas na construção da notícia, apesar da presença majoritária de profissionais mulheres na área da saúde no Brasil.
Church and folk names of Orthodox holidays in the Khakass language
Authors: Guseinova Aurika
Published: August 2022

The article is devoted to the study of the peculiarities of church (calendar) and folk (everyday) names of Orthodox holidays in the Khakass language in the theolinguistic aspect. The research was carried out on the material of publications of the diocesan newspaper "Сын сабланыстығ киртiнiс" ("Orthodox Faith"), as well as calendars and dictionaries of the Khakass language. The topic of the article is relevant due to the insufficient degree of development of the problems of the scientific description of the religious vocabulary of the languages of the indigenous peoples of Siberia, including the Khakass language. The novelty of the work is determined by the fact that it was carried out on the basis of Khakass heortonyms, which had not previously become an object of scientific research. The author found that the Khakass church names of religious holidays are often tracing copies of Russian names, which, in turn, repeat the basic structure of Greek nominations, and a certain cultural specificity is manifested in the folk ones. The author divides the folk heortonyms of the Khakass language into two groups, the first of which refers to the names that arose by transferring the name of the attribute of a certain holiday to the holiday itself, and the second — names that are distorted Russian heortonyms. Answering the question, what is the reason for the presence of folk heortonyms to indicate some holidays and absence for others, the author concludes that their presence is determined either by the features of the celebration of a religious event, or its economic significance. The author concludes that further research is needed on the religious vocabulary of the Khakass language and its fixation in dictionaries
The new language of the Internet: sources and mechanisms for the emergence of new vocabulary
Authors: Nedostup Oleg , Pleshivtseva Elena
Published: August 2022

The article analyzes some of the features of the new language — the language of virtual communication, which functions in colloquial discourse. The authors of the article made an attempt to identify the sources of the formation of the language of the virtual space, to determine the linguistic mechanisms that determine the lexical and grammatical changes in the language of "Newspeak". It was revealed that one of the most productive sources of new vocabulary and the rules for its functioning is the English language, therefore the authors of the article compared some linguistic processes occurring in English with the processes observed in the Russian-language segment of the spoken Internet discourse. In the course of the analysis of the empirical material, it was revealed that the Russian-speaking segment of the Internet is currently being actively replenished with borrowings from the English language, in particular, slang expressions from the IT sphere. The authors of the article came to the conviction that the process of replenishing the Russian-speaking segment of the Internet from the thesaurus of English slang is a global process, which is a kind of “linguistic feed” for the entire Russian-speaking colloquial Internet discourse. Moreover, the abundance of Anglicisms in the Russian language contributes to the activation of two important word-formation processes — errativization and Internet abbreviation. The first process is due to the gravitation of the language of network communication to change words according to the principle of a language game, in particular, to phonetic writing ("krasafcheg", "lead"). Note that the formation of errativs is fully characteristic of the English language, which, in turn, may indicate the process of errativization as a universal linguistic phenomenon. The second process of forming a new layer of Internet vocabulary can be considered abbreviation (including abbreviations and graphons). This word-formation process in Russian colloquial discourse is realized through colloquial abbreviations, especially of an occasional nature or created by tracing. We also noted the role of Russian syntactic derivation, which is similar to the English derivational model. The authors of the article also drew attention to the activation of the deverbatization process, which is similar in grammatical characteristics to the gerund in English. The authors of the work come to the conclusion that the activation of word-formation processes in the language of network communication is directly related, firstly, to the fact of constant reception of words from the English language, and secondly, to the process of the influence of language models of the English language on the word-formation system of the Russian language.
Linguistic argumentative approach to the analysis of the vestimentary discourse of the Soviet periodical press of the 1960s
Authors: Manasyan Liana
Published: August 2022

This article is part of the author’s dissertation research. Our research, which began with the study of fashion discourse in general and the fashion discourse of the 1960s in particular, led us to the discovery of the fact that in this field there are currently no linguistic works covering the period of the second half of the 20th century.
The author presents a review of several Russian-language sources — monographs and articles written in the 21st century by Russian researchers in the fields of cultural studies, art history, sociological and economic research, analysing the features of the 1960s era in the spheres of production and consumption in the Soviet Union.
Our article presents a linguistic argumentative approach to the analysis of the vestimentary discourse that unfolded on the pages of Soviet printed periodicals in the 1960s; articles and notes from the newspaper “Sovetskaya Kultura” [Soviet Culture] were especially interesting for us. In the article, we pay attention to the following aspects identified by us, inherent in the newspaper vestimentary discourse of the analysed era: the tactics of exposing anti-creativity (detective script); actualisation of the effect of deceived expectations; objectivity and subjectivity of professional discourse; reflection as a factor of the adequate implementation of vestimentary discourse elements (explicativeness of discourse); the tone of discourse (an optimistic ending as the author’s attitude). Each of the listed blocks of our work is illustrated by vivid examples — excerpts from two articles from the newspaper “Sovetskaya Kultura” [Soviet Culture] for 1960 and 1965. Using the methods of contextual and linguistic argumentative analysis, we find that the Soviet vestimentary discourse of the 1960s was characterised by dialogueness, explicativeness, and concern for the addressee.
The results of our research can be practically applied in teaching the following disciplines: discourse and communicative practices, linguistic argumentation, text analysis and interpretation, the history of Russian journalism, the language of press.
Observation of Electrical, Dielectric and Magneto-dielectric Properties of Terbium Doped Bismuth Ferrite Nanoparticles above Room Temperature
Authors: Halder Monalisa , Datta Jinia , Mallick Raja , Sinha Ranjita , Smriti Khusi , Raul Chandan Kumar , Atta Shubhadip , Meikap Ajit Kumar
Published: August 2022

The effect of rare earth transition metal (Tb) ions doping in A site of bismuth ferrite (BFO) nanoparticles are studied from electrical, dielectric and magneto-dielectric aspects. A detailed study on dielectric properties of the Tb doped bismuth ferrite nanoparticles is done over a
wide temperature range in a frequency range of 20 Hz - 2 MHz. Observation on magneto-dielectric response of the sample is done at room temperature upon applying external transverse magnetic field.