bluuebunny/crossref_metadata_2025 huggingface dataset:
PERSONAL EXPERIENCE OF THE MIGRATION OF UKRAINIAN WOMEN DURING THE RUSSIAN-UKRAINIAN WAR (DIARIES OF O. KARI “LIFE IN THE MIDDLE OF LIFE”, N. SUKHORUKOVA “MARIUPOL. NADIIA” AND T. BELIMOVA “BIZHENKA”)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, YANTSELEVYCH Olesia
Published: June 2024

The article focuses on analyzing the diaries of the Ukrainian women, their personal experience of migration during the Russian- Ukrainian war, which began with the Revolution of Dignity November 21, 2013, or the Eurorevolution, Euromaidan, the place where the events developed. It is when the Ukrainian people protested against the then prorussian leadership and its rejection of the course towards the European integration. The Heavenly Hundred February 20, 2014 is the first hundred killed insurgents in this Revolution, which continued with war. Russians did not recognize their invasion of Ukraine. They annexed Crimea too quickly – March 18, 2014. Then the Donetsk region – April 7, 2014, criminally forming the separatist, puppet Donetsk People’s Republic and, April 27, 2014, the Luhansk People’s Republic. Therefore, we are currently witnessing the period of development of a new literature about the war, which seeks an academic attention in order to analyze its multigenre, reader reception, artistic and historical value, influence on the creation of the contemporary literary canon. The diary genre was the first, after poetry, to react to this genocidal war. The diaries of O. Kari, N. Sukhorukova, and T. Belimova attracted the attention of readers, scholars, film directors, and the European community. The genre of the diary is a vivid example of auto-documentary prose, which is provocative, extraordinary, relevant in its content, form and functions, constantly developing and acquiring new genre modifications. The post-colonial approach to the analysis of diaries’ texts as historical evidence makes it possible to talk about trauma, life in trauma, colonialism, colonizer, imperial thinking, violent imposition of a totalitarian regime.
ENVIRONMENTAL TREND IN BUSINESS MODEL DEVELOPMENT
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Magomedova Alina
Published: June 2024

Current economic tendencies stimulate entrepreneurs to seek innovative and sometimes revolutionary approaches to business conduct. Companies aiming to be trendsetters are characterized by their significant impact on addressing current social and environmental challenges. Projections indicate a nearly quadruple growth in the global market for green technologies and sustainable development. Nowadays, companies have access to modern tools in order to minimize negative environmental impact. Digitalization and sharing economy promote for generating tools to address environmental issues, with generational shifts intensifying societal focus on such concerns. Consequently, adherence to principles of sustainable development, particularly in the context of addressing environmental challenges, is a crucial aspect of modern business performance. Ukrainian businesses face the challenge of adapting to the European Green Deal, necessitating a review of their environmental goals and strategies for competitiveness. With the establishment of ambitious environmental goals, companies are compelled to reshape their business models. The influence of the environmental trend on shaping each element of a company's business model is important. Business model Canvas avails to recognize this impact. Analyzed customers segments and offering eco-centric value propositions are crucial for success. Key activities, especially in resource-intensive sectors like manufacturing, require innovation for environmental responsibility. Collaboration with stakeholders is essential for eco-friendly execution, as companies remain dependent on suppliers whose resources can provide neutralize harmful environmental impacts. Thus, environmental production primarily relies on innovation, despite the additional investments and risks involved.
HR ANALYTICS IN THE SYSTEM OF EFFECTIVE USAGE OF HUMAN CAPITAL IN AN ENTERPRISE IN THE CONTEXT OF MODERN CHALLENGES
Authors:   Taras Shevchenko National University of Kyiv, Nosal Oleksandr
Published: June 2024

The study focuses on the role of HR analytics as a tool for effective human capital management in organizations. The article aims to investigate the methods of collecting, analyzing and interpreting data on employees and their impact on strategic decision-making in HR; prove that the use of HR analytics can contribute to improving productivity, engagement and general well-being of employees, as well as contribute to achieving the company's business goals in the face of modern challenges. The article considers the relevance and necessity of using HR analytics as a tool to improve the efficiency of human capital management in enterprises in the context of modern economic and social challenges. The analysis of theoretical approaches to the definition of the concept of "human capital" and "HR-analytics," highlighting the importance of these areas to increase the competitiveness of the enterprise and adapt to changing market conditions. A classification of the main methods and techniques of HR analytics that can be used to optimize the processes of attracting, developing and retaining employees is presented. The article also discusses the benefits of implementing analytical tools in strategic personnel management and developing recommendations for improving the efficiency of work with human resources in the enterprise. The article notes that modern market challenges require HR specialists not only a high level of understanding of business processes, but also knowledge of HR analytics methods for making informed decisions based on objective data. The article examines examples of implementation of HR analytics by large Ukrainian companies, provides key indicators of HR analytics, offers tools for the introduction of HR analytics by an enterprise to increase the efficiency of using the company's human capital in the face of modern challenges. In the context of the constant change in the business landscape, the article focuses on the strategic role of HR analytics in the formation of flexible and responsible personnel strategies that can quickly adapt to new market conditions and ensure sustainable business. The main idea of the article is to prove that in the difficult conditions of the present, HR analytics plays a key role in ensuring the long-term success of the organization, helping HR specialists to be not just managers of personnel, but strategic partners who can influence decisions that shape the future of the company.
PROSPECTS AND CHALLENGES OF INTELLECTUAL PROPERTY COMMERCIALIZATION DEVELOPMENT DURING THE WAR IN UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Virchenko Volodymyr , Virchenko Vira ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: June 2024

The paper focuses on studying the nature, current state, challenges and risks of economic turnover of intellectual property during wartime, and also on identifying the prospects for the development of intellectual property commercialization in the context of the economic recovery of Ukraine. The essence and main stages of intellectual property commercialization are analyzed, including acquisition of intellectual property rights, intellectual security provision, valuation of intellectual property rights, planning of the commercialization process, development of depreciation and accounting policies, resource mobilization, manufacturing of innovative products, extracting value added from the market through the sale of innovative products, and analysis of commercialization performance. The authors demonstrate that the introduction of intellectual property objects into commercial activity allows enterprises to technologically upgrade production and generate economic profit by creating and selling innovative products with new consumer characteristics that are able to meet new customer needs, which gives companies an advantage over competitors in the modern globalized markets. The current state and dynamics of intellectual property sphere in Ukraine in the pre-war period and during the full-scale war are investigated. The article shows that russia's full-scale invasion of Ukraine led to an average 40% reduction in the number of applications for registration of intellectual property rights in 2022. Despite the fact that in 2023 the number of applications increased by an average of 47%, it was still not possible to reach the pre-war levels of registration activity. The main challenges and risks of intellectual property commercialization in wartime are identified, including the deterioration of the investment climate, which hinders the fundraising for intellectual property commercialization projects; the reduction of intellectual potential due to the migration of more than 5 million Ukrainians abroad; the objective inability of the state to support innovative companies in Ukraine in the face of a budget deficit. The authors prove that even in the face of existing challenges, active commercialization of intellectual property can enable Ukraine to create new workplaces, realize its innovative potential, upgrade manufacturing facilities, and launch modern products with new high-quality features that can ensure the competitive position of domestic companies in global product markets.
ANALYSIS OF INTERNATIONAL COMPETITIVENESS OF AGRO-INDUSTRIAL COMPLEX OF UKRAINE AND COUNTRIES OF THE WORLD IN THE CONDITIONS OF INDUSTRY 4.0
Authors:   National Technical University of Ukraine “Kyiv Polytechnic Institute”, Kyiv, Ukraine, Hlushchenko Ya. I. , Ozharovska O.V.
Published: June 2024

The article is devoted to the international competitiveness of the agro-industrial complex of Ukraine and the countries of the world that are its largest competitors: Brazil, China, India, Turkey and the United States. The purpose of the article is to determine the advantages and problems of international competitiveness of the domestic agro-industrial complex in comparison with the largest competing countries in the context of technological development and implementation of Industry 4.0. The results obtained can be used in the creation of a a concept for improving the international competitiveness of Ukraine's agro-industrial complex. To achieve this goal, the research was conducted using the following methods: comparative analysis, economic and statistical methods, namely, the method of processing a dynamic series to identify a trend, graphical and tabular methods to visualize the observed data and research results. The analysis of time series for 2003-2022 showed that among the countries studied, Ukraine has the largest share of agricultural exports in GDP by a significant margin. The assessment of the dynamics of the foreign trade balance showed that Brazil, Ukraine and India are significant players as net exporters of agricultural products on the international market, while countries such as the United States and China are becoming increasingly dependent on agricultural imports, acting as net importers. The analysis of the structure of agricultural exports showed that Brazil, China, and India have the highest diversification of agricultural exports. As for the value of exports, Brazil and the United States are in the lead. It is established that in terms of the relative indicator, namely the share of exports of agro-industrial goods, Brazil, India and Ukraine prevail. The author notes a significant potential for increasing the international competitiveness of domestic agricultural products, strengthening Ukraine's position in the global agricultural segment, which can serve as an indicator of the efficiency and competitiveness of the Ukrainian agro-industrial complex.
TRASFORMATION OF UKRAINE'S FINANCIAL ASSETS AMID THE DEVELOPMENT OF THE INTERNATIONAL FINANCIAL SYSTEM
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Delas Vitalina , Rak Roman ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: June 2024

The work has analysed the state of financial assets and their dynamics in the international financial system, considering the global changes in the financial architecture and financial relationships observed over the last decade. It has been observed that in 2020, global financial assets exceeded world GDP more than 18 times and consisted of three main equivalent components: assets of the real sector of the economy, assets of the financial sector, and assets of the financial sphere. The study has revealed that investment in intangible assets has slowed over the past two decades while investment in real assets, particularly in real estate, has become more active. Regularities in the relationship between the decrease in interest rates, the growth rate of GDP, and the directions of investment of funds in the leading countries of the world have been followed. This provides a basis for conclusions regarding further changes in the structure of global financial assets. The article has also raised issues of feasibility and riskiness of further increasing the amount of debt capital on a global scale in the context of some revision of its impact on the world economy after the 2008 crisis. Integration processes in Ukraine prompt the analysis of trends in the formation of financial assets in our country, with indicators similar to those of developed countries and global indicators in general. A comparison of global trends and indicators of the development of Ukraine's financial assets has highlighted significant differences both in percentages of GDP and in their structure; in particular, attention has been paid to the uneven development of various sectors of the financial market of Ukraine — the significant development of the banking sector along with the laggards of the stock market. This indicates an important gap in the development of the Ukrainian financial sector and the need to reform it to integrate into the global economic space.
THE IMPACT OF INNOVATION ON THE PERFORMANCE OF SMALL AND MEDIUM-SIZED ENTERPRISES IN RUSSIA: ЕMPIRICAL ANALYSIS
Authors: Sererzhin P. D.
Published: June 2024

The article is devoted to the study of the impact of different types of innovation on the efficiency of Russian SMEs. The purpose of the study is to assess the importance of different types of innovation for Russian SMEs and to determine the impact of types of innovation on the efficiency and competitiveness of SMEs. The research methodology involves a consistent approach combining qualitative and quantitative analysis. As a collection of information, a survey was conducted among owners of small and medium-sized enterprises in Russia on the use of innovations in the course of business activities in the last three years (2020–2023) and their impact on the company՚s performance. In addition, the experiences of some participants were explored through in-depth interviews. In total,

112 entrepreneurs took part in the survey. The results of the study showed that innovations are used by the vast majority of small and medium-sized enterprises in Russia. There is no stable relationship between the size of enterprises and the innovations they choose, although in some cases we can say that certain companies tend to a certain type of innovation depending on the number of employees. Organisational innovations are the least popular in enterprises innovation, and the greatest marketing; marketing innovations showed the highest percentage of negative experiences during implementation, despite the fact that they are the most popular category of innovations.

The majority of respondents see an improvement in the financial situation of the company according to various criteria and are satisfied with the results of innovation; at the same time, the larger the company, the more goals it pursues trough innovations. The smaller the business, the more interested it is in solving specific problems to increase sales, profits and customer loyalty. The larger the company, the more it follows the 360 strategy: that is, it pays attention to the creation of new goods and services, as well as to the introduction of innovations in production processes.
Doğu Akdeniz Bölgesi Modern Seralarında Farklı Örtü Malzemesi ile Farklı Isı Perdesi Kullanımının Sera Isı Gereksinimine Etkisinin Belirlenmesi
Authors: Üstün Sait , Çölkesen Elif Kübra , Bolat Katibe Gülşah , Hayırsöz Gülçin
Published: June 2024

Bu çalışmada, Doğu Akdeniz Bölgesindeki Antakya, Mersin, Adana ve Antalya illerinde yer alan ileri teknolojik seralarda ihtiyaç duyulan ısı gereksinim değerleri hesaplanmıştır. Hesaplamalar, farklı örtü malzemesi ve çeşidi ile ısı perdesinin farklı sızdırmazlık özelliklerinin kullanıldığı her bir il için 24 sera tipi için ayrı ayrı yapılmış ve karşılaştırmaları verilmiştir. Isı perdesiz hesaplamalarda optimum ısı enerjisi gereksinimi Adana, Mersin, Antalya ve Antakya için sırasıyla cam seralarda 79.9 kW h m-2 a-1, 80.8 kW h m-2 a-1, 104.8 kW h m-2 a-1, 117.9 kW h m-2 a-1, plastik seralarda ise 78.7 kW h m-2 a-1, 81.9 kW h m-2 a-1, 105.6 kW h m-2 a-1, 116.3 kW h m-2 a-1 olarak bulunmuştur. Isı perdeli hesaplamalarda ise optimum ısı enerjisi gereksinimi Mersin, Adana, Antalya ve Antakya için sırasıyla cam seralarda 49.0 kW h m-2 a-1, 53.0 kW h m-2 a-1, 61.4 kW h m-2 a-1, 75.9 kW h m-2 a-1, plastik seralarda ise 53.2 kW h m-2 a-1, 54.6 kW h m-2 a-1, 66.5 kW h m-2 a-1, 79.0 kW h m-2 a-1 olarak bulunmuştur. Hesaplamalar sonucunda optimum ısı maliyetini sağlayan sera tipi, cam örtülü seralar için C8, PE örtülü seralar için ise P16 olarak belirlenmiştir. Çelik borulu ısıtma sisteminde boruların seraya yerleştirilme şekli olarak en iyi sonuç sera tabanına yakın yerleştirilmesi ile sağlanırken, sızdırmazlığı iyi ısı perdelerinin kullanılması gerektiği belirlenmiştir. Sonuç olarak, Doğu Akdeniz Bölgesi ileri teknolojik seralarda optimum ısı maliyetinin sağlanması için cam seralarda, çatıda tek kat cam, yan duvarlarda çift kat cam, PE seralarda ise çatı da tek kat PE, yan duvarlarda ise çift kat sert PE (32 mm) kullanılmalıdır. Çelik borulu ısıtma sisteminde borular sera tabanına yakın yerleştirilmeli ve ısı koruma önlemi olarak da ısı perdeleri kullanılmalıdır.
Innovative Approaches to Recycling Rubber Waste in the United States
Authors: Tejani Jayadip GhanshyamBhai
Published: June 2024

In the United States, managing rubber waste—especially from tires—presents severe environmental problems. This project aims to evaluate novel techniques for recycling rubber waste to appraise existing practices, examine new technologies, and suggest policy suggestions for sustainable waste management. The paper thoroughly analyzes US rubber waste recycling research and secondary data sources. Important discoveries highlight the shortcomings of traditional recycling techniques, including problems with quality and the environment. Cutting-edge technologies that have the potential to improve resource recovery and lessen environmental impact include devulcanization, pyrolysis, and chemical recycling. The policy implications underscore the necessity of infrastructure expenditures, cooperative collaborations, and regulatory incentives to expedite the implementation of novel recycling processes. Regulatory frameworks should be updated, research and development should be encouraged, and end-market potential for recycled rubber products should be promoted. This study emphasizes how critical it is to switch to creative methods of recycling rubber waste to address environmental issues and advance the circular economy. The United States can lead the way in creating an ecosystem for recycling rubber waste that is more effective and sustainable by enacting legislative changes and utilizing cutting-edge technologies.
Plasmacytoid Dendritic Cell Leukemia: Updated Review
Authors: Carolina Jácome , Eugenia Buestán , Paul Otáñez , Carolina Paul , Estefanía Ramón
Published: June 2024

This review article compiles updated information on Plasmacytoid Dendritic Cell Leukemia, a type of uncommon or rare myeloid neoplasm, with typically cutaneous manifestations with or without extramedullary involvement and leukemic dissemination, which makes it difficult to differentiate from other neoplasms. This review aims to provide a brief update on key points such as its epidemiology, pathogenesis, diagnosis and treatment, in order to allow early recognition of the disease considering its rapid evolution and poor prognosis.
Management of Medial Tibial Stress Syndrome with Glucopuncture. A Clinical Case.
Authors: Kersschot Jan , Gharaei H , Mathieu T , Ferrie J
Published: June 2024

Medial tibial stress syndrome, sometimes referred to as shin splints, is an overuse injury of the lower extremities. It is commonly managed conservatively, but there is lack of consensus on the application of new treatment options such as regional dextrose 5% injections in regional superficial fascia. Over the last decade, regional dextrose 5% injections are popular for the treatment of orthopedic complaints and sports injuries because of easy application, low cost and excellent safety profile. This article describes a 25-year-old runner suffering from pain in both shins for several years. His pain level went from 7/10 to 0/10 after three sessions of dextrose 5% injections in the superficial fascia, and he recovered permanently after five sessions. This case report is an invitation to design more studies to confirm whether this novel approach may become one of the new tools for athletes suffering from shin splints.
Trends in revision hip replacement surgery - a 21-year review of the New Zealand Joint Registry
Authors: Williams P , Hannah A , Henley E , Frampton C , Hooper G
Published: June 2024

Introduction: This study aimed to examine the changing trends in the reasons for total hip replacement (THR) revision surgery, in one country over a twenty-one-year period, in order to assess whether changes in arthroplasty practices have impacted revision patterns and whether an awareness of these changes can be used to guide clinical practice and reduce future revision rates. Methods: The reason for revision THR performed between January 1999 and December 2019 was extracted from the New Zealand Joint Registry (NZJR). The results were then grouped into seven 3-year periods to allow for clearer visualization of trends. The reasons were compared across the seven time periods and trends in prosthesis use, patient age, gender, body mass index (BMI) and American Society of Anesthesiologist (ASA) grade were also reviewed. We compared the reasons for early revision, within one year, with the overall revision rates. Results: There were 20,740 revision THR registered of which 7665 were revisions of hips with the index procedure registered during the 21-year period. There has been a statistically significant increase in both femoral fracture (4.1 - 14.9%, p<0.001) and pain (8.1 - 14.9%, p<0.001) as a reason for hip revision. While dislocation has significantly decreased from 57.6% to 17.1% (p<0.001). Deep infection decreased over the first 15 years but has subsequently seen further increases over the last 6 years. Conversely both femoral and acetabular loosening increased over the first 12 years but have subsequently decreased over the last 9 years. The rate of early revisions rose from 0.86% to 1.30% with a significant rise in revision for deep infection (13-33% of all causes, p<0.001) and femoral fracture (4-18%, p<0.001), whereas revision for dislocation decreased (59-30%, p<0.001). Adjusting for age and gender femoral fracture and deep infection rates remained significant for both (p<0.05). Adjusting for age, gender and ASA was only significant for infection. Conclusions: The most troubling finding was the increased rate of deep infection in revision THR, with no obvious linked pattern, whereas the reduction in revision for dislocation, aseptic femoral and acetabular loosening can be linked to the changing patterns of the use of larger femoral heads and improved bearing surfaces.
Innovative Healthcare Digital Transformations During and After the COVID-19 Pandemic Crisis
Authors: Paul Jijo
Published: June 2024

Objective: Almost all countries have faced enormous financial, economic, operational, and clinical pressure since the coronavirus disease 2019 (COVID-19) pandemic raised numerous challenges in healthcare services/ businesses. The United States adopted various healthcare strategies and applied them successfully to reduce pandemic mortality rates in the last couple of years. This article focused on various innovative digital transformation strategies used in healthcare businesses/ services, including the role of digitization, digital transformative technologies, and different communication methods to overcome pandemic and post-pandemic periods. Methods: This study systematically reviewed articles on the early pandemic, the pandemic, and post-pandemic periods, and the related literature was collected using MEDLINE, Medical Subject Headings (MeSH), and medRxiv platforms with appropriate search terms. Articles are categorized based on the title, journal, and publication date. Most of the articles were classified based on the kinds of digital technologies used. Results: Many countries have used various digital platforms and technologies to manage numerous issues caused by the pandemic. The organizations' healthcare managers mostly use electronic media to communicate with co-workers and patients. A swift shift in business strategies is required during and after the pandemic; customers are seriously considering a stress-free consumer experience through trusted organizations. The demand for innovation in healthcare has dramatically increased, using advanced technology implementations that raise healthcare businesses to a new horizon with digitalization and a consumer-friendly atmosphere; moreover, it supports branding and organizational reputation in the healthcare field. Conclusion: Many businesses have adopted digital technologies to reach customers and improve their experiences since they can enjoy streamlined services, build brands/ credibility, and gain patient loyalty. Digitalization is promising, and several benefits have been identified from using digital healthcare. The government should invest more in public health sectors to promote digitalization since the pandemic-like scenario is unpredictable.
Parotid Metastasis from Squamous Cell Carcinoma: Surgical Resection and Microsurgery Reconstruction: a case report
Authors: Pazmino Paola , Osowski Luiz , Zittlau Bruno , Pazmino Daniel , Zanella Virgilio
Published: June 2024

Introduction and importance: Squamous cell carcinoma (SCC) accounts for approximately 20% of nonmelanoma skin cancers, with a significant proportion arising in the head and neck region. Up to 5% of these lesions’ present nodal metastases, particularly to the parotid gland, attributed to the extensive lymph nodes in and around the gland. Treatment typically involves surgical resection, including cervical lymph node dissection, with adjuvant radiation therapy recommended in select cases. Reconstruction using a microsurgery-assisted free anterolateral thigh flap is valuable in complex cases such as SCC with parotid metastasis, providing optimal reconstruction outcomes and improving patient quality of life. Case presentation: We presented a 68-year-old woman with squamous cell carcinoma (SCC) in the left parotid gland and metastasis. The patient had a history of SCC in the left zygomatic region. The parotid lesion exhibited rapid growth and was associated with various symptoms, including eye pain, hearing loss, tinnitus, and headache. Discussion: Treatment involved left extended total parotidectomy, ipsilateral supraomohyoid neck dissection, and reconstruction with a microsurgery-assisted free anterolateral thigh flap. Conclusion: Comprehensive care, from early diagnosis to skilled surgery, is vital for improving outcomes in squamous cell carcinoma, particularly with parotid metastases.
Navigating the Gastrointestinal Implications of Coronavirus 19: Strategies and Lessons Learned
Authors: Chennupati Karteek
Published: June 2024

In 2019, an outbreak of COVID-19 caused by SARS-CoV2 spread worldwide, affecting millions of individuals. This was colloquially termed the “COVID-19 Pandemic.” As the pandemic progressed, multiple variants of SARS-CoV2 continued to evolve, including the most recent JN1, and spread worldwide, causing a broad spectrum of symptoms affecting multiple organ systems. The purpose of this article is to comprehensively explore COVID-19 through the lens of the Gastrointestinal system (GI) and review the treatments. The prevalence of GI symptoms in COVID-affected patients ranged from 28.2% to 50% throughout the pandemic. The predominant symptoms include nausea, diarrhea, reflux, abdominal pain, and emesis. Interestingly, these symptoms persisted for an extended time, sometimes the most bothersome, even after the resolution of an active infection. Due to the nature and prevalence of these symptoms, it is imperative that we understand the mechanism of interaction of SARS CoV2 and the GI system and its pathophysiology. Despite being the less common transmission route, the fecal-oral route is to be considered when devising public health strategies. The term “Long Covid” has been coined due to the long-term symptoms after active infection, and interestingly, GI symptoms have a significant prevalence. Though unclear, the pathogenesis is thought to be due to gut dysbiosis and dysbiosis of the gut-brain connection. In this article, we have also discussed the GI symptoms and treatment of COVID infection in inflammatory bowel disease, pediatric population. We have also discussed guidelines by gastroenterology societies for care prior to, during, and after endoscopy, as well as ostomy care in COVID patients.
Survey on the awareness of COVID-19 virus infection among the health personnel of Sirajganj area, Bangladesh
Authors: Ali Shaikh M. Eunus , Akter Dilara , Bhuiyan Mohammad Kamal Uddin , Rahman Inamur , Sarker Nabid Shahriar , Rubab Khadiza
Published: June 2024

Background: The COVID-19 pandemic has posed significant challenges to healthcare systems worldwide, particularly in resource-limited settings. Understanding the awareness and practices of health personnel regarding COVID-19 is crucial for effective infection control and patient care. This study aims to assess the awareness of COVID-19 symptoms, complications, transmission methods, and preventive practices among health personnel in Sirajganj, Bangladesh.
Methods: This descriptive cross-sectional study involved 260 health personnel from Shaheed M. Monsur Ali Medical College and the 250 Beded Sheikh Fazilatunnesa Mujib General Hospital, Sirajganj. Data were collected through a semi-structured questionnaire, focusing on COVID-19 awareness and practices. The study employed purposive sampling and face-to-face interviews for data collection.
Results: The study found high awareness of COVID-19 symptoms, with 96.15% recognizing fever and 97.69% identifying loss of smell. Awareness of complications like respiratory failure (80.00%) and pneumonia (60.77%) was also notable. Preventive practices such as handwashing (98.08%) and mask-wearing (98.08%) were widely adhered to. However, 36.15% of participants reported being affected by COVID-19, indicating potential exposure risks.
Conclusions: The study reveals a high level of awareness and adherence to COVID-19 preventive measures among health personnel in Sirajganj. Despite this, the infection rate among participants highlights the need for enhanced protective measures and continuous education. These findings can inform strategies to strengthen healthcare responses to ongoing and future pandemics.
Understanding the knowledge and experience of menarche among secondary school female students in Nnewi, Anambra State, Nigeria
Authors: Chiekezie Chinonuju Franklin , Edeh Gabriel Chidera , Ekwebene Onyeka Chukwudalu , Chiekezie Chisimdi Marysandra , Chiekezie Chukwuebuka Kingsley , Okonkwo Benjamin Chukwunonso , Ashibogwu Ezinneamaka Maureen , Awugosi Michael Chukwuebuka
Published: June 2024

Background: Menstruation, a key physiological change in females of reproductive age, necessitates providing young girls with crucial information on menarche to better prepare them.
Methods: This study assessed the knowledge and experience of menarche among secondary school female students in Nnewi, Anambra State, Nigeria, utilizing a descriptive cross-sectional survey method. Conducted from August to September 2023, the study involved 420 participants and employed multistage sampling for selection.
Results: The findings revealed a paradoxical decrease in the mean age of menarche to 12.02 +/- 1.15 years, with most girls experiencing menarche at age 13. Notably, 91.4% of participants had substantial knowledge of menarche, primarily acquired from mothers. Although 86.9% recognized menarche as a normal puberty change, experiences varied: 45.5% felt normal, 39.3% were afraid, and 12.9% felt ashamed during their menarche.
Conclusions: The study concludes that despite high awareness levels, poor menarche experiences prevail due to inadequate preparation. It recommends enhanced awareness campaigns in schools, spearheaded by NGOs and health workers, to educate and prepare young girls for menarche effectively.
Tumor budding in invasive breast carcinoma: an emerging prognostic factor
Authors: Devashwar Reetika , Mishra P. S. , Venkatesan S. , Bhatia Jasvinder Kaur
Published: June 2024

Background: Tumor budding refers to single or small cluster of tumor cells detached from the main tumor mass in histological sections. In colon cancer high tumor budding is associated with worse prognosis and correlates with metastatic lymph nodes. We studied tumor budding in modified radical mastectomy specimens to evaluate its utility as a prognostic factor by correlating high tumor budding score with known prognostic markers of breast cancer like axillary lymph nodal metastasis, clinical staging, tumor size, lymphovascular invasion, hormonal status and pathological grading. Aim was to evaluate tumor budding in invasive breast carcinoma and to describe clinical features and histopathological spectrum of Invasive Breast Carcinoma with/without lymph node metastasis on H&E slides. Secondly, to find association between grades of tumor budding and various clinical, gross, microscopic and immunohistochemical variables.
Methods: The present study is a cross sectional study of 70 modified radical mastectomy specimens from June 2018 to Dec 2022. Along with tumor budding various prognostic parameters like hormonal markers, pathological grading and clinical grading were evaluated. Immunohistochemical marker Pancytokeratin was utilized for counting the tumor buds, wherever necessary. Statistical Analysis: Chi Square test was utilized to study significant differences between variables, p<0.05 was considered statistically significant.
Results: A high tumor budding score (≥4/HPF) had significant association with axillary lymph node involvement and clinical staging.
Conclusions: In our study we detected the association of high tumor budding, PTB in invasive breast carcinoma with axillary lymph node involvement and clinical staging. Hence our results highlight the importance of tumor budding as a prognostic factor and submit that this histological feature could be included in diagnostic protocols just as in carcinoma of the colon.
An analytical study of annual bleeding rates in haemophilia patients receiving low dose factor prophylaxis and those receiving episodic factor doses
Authors: Pathradkar Mrunal , Bafna Varun , Paritekar Anita
Published: June 2024

Background: This study aimed to assess the impact of low dose factor prophylaxis on haemophilia patients with respect to annual bleeding rates and severity of bleeding events.
Methods: This is an analytical study. All patients of HAEMOPHILIA A AND B who are registered with CPRH haemophilia treatment centre from January 2022 to December 2022 were included and were followed up every month from January 2022. The study population was divided into two groups: those receiving regular low dose factor prophylaxis and those receiving episodic factor treatment. Both the group participants were matched for severity of factor deficiency and age. The collected data was compared with respect to the annual bleeding rate as well as severity of bleeding episodes in the two defined groups.
Results: There were 100 study patients, and 16 of them are receiving regular low dose factor prophylaxis. The average bleeding episodes were found to be more in patients receiving episodic factor doses (ABR in moderate haemophilia= 3.511+/-0.81, ABR in severe haemophilia=5.38+/-4, 53) as compared to those receiving prophylactic factor doses (ABR in moderate haemophilia = 0.16+/-0.32, ABR in severe haemophilia=0.3+/-0.29). The incidence of severe bleeds (those requiring hospitalisation) was higher in patients receiving episodic factor therapy (15) as compared to those receiving regular low dose factor prophylaxis (1).
Conclusions: Haemophilia patients receiving episodic factor doses have higher Annual Bleeding Rate as compared to patients receiving regular low dose factor prophylaxis. Also, patients receiving prophylaxis face less severe forms of bleeding episodes as compared to other group of patients.
Profile and outcome of treatment in non-small cell lung cancer with brain metastasis
Authors: Rehman Uzma , Khan Nazir Ahmed , Nasreen Shahida , Gadda Irfan Rasool
Published: June 2024

Background: Brain metastasis is a common problem in patients with NSCLC. This study was done to study the risk factors associated with the development of brain metastasis and assess treatment response in NSCLC to improve patient survival.
Methods: This was a retro-prospective study in which 126 patients with non-small cell lung carcinoma with brain metastasis were taken for the study.
Results: The mean age in study group was 56.1±12.72 years. Adenocarcinoma was found in 57.1% and squamous cell carcinoma in 41.3% patients. 65.9% patients received chemotherapy for primary disease followed by targeted therapy in 34 (27.0%) patients. 53.9% patients received WBRT after diagnosis  of brain metastasis and 23% WBRT and systemic chemotherapy while as14.3% received WBRT and targeted therapy and 2.4%  received WBRT, systemic chemotherapy and targeted therapy, 1.6%  patients received systemic chemotherapy, WBRT and local RT to the primary site  and 0.8% each was treated with gamma knife therapy; surgery, WBRT and targeted therapy; SRS and WBRT. Median overall survival of patients with brain metastasis who received WBRT was 2.5 months and patients who received WBRT and systemic chemotherapy was 9.0 months while patients with brain metastasis who received WBRT and targeted therapy was 14.3 months.
Conclusions: The median overall survival as per treatment received after diagnosis of brain metastasis was higher in patients who received WBRT and targeted therapy as compared to patients who received WBRT and systemic chemotherapy and patients who received WBRT only.
Vitiligo and depression: an observational study in patients attending tertiary care centre
Authors: Katroliya Preetam Singh , Vyas Devesh , Argal Deepak , Patel Nishant
Published: June 2024

Background: Vitiligo, a chronic skin disorder characterized by depigmentation and white patch formation, not only poses a cosmetic challenge but also imposes a significant psychological burden. The relationship between vitiligo and depression remains underexplored, despite growing recognition of their potential association. This observational study aimed to investigate the prevalence of depression and assess the quality of life (QoL) among patients with vitiligo attending a tertiary care center.
Methods: A cross-sectional study was conducted at the dermatology and psychiatry departments of SRVS Medical College, Shivpuri, involving 150 vitiligo patients aged 18 to 60 years. Participants were assessed using the patient health questionnaire (PHQ-9), vitiligo area scoring index (VASI), and dermatology life quality index (DLQI). Statistical analyses were performed using statistical package for the social sciences (SPSS) version 26.
Results: The mean age of participants was 38.55±14.82 years, with 69.3% being female. Nonsegmental vitiligo accounted for 84% of cases, and 42.6% had active disease. The mean DLQI score was 8.45±6.12, with female gender and active disease significantly associated with lower QoL scores. A strong correlation was observed between depressive symptoms and impaired QoL (DLQI). The prevalence of depression (PHQ-9 score ≥9) was 14.6%, with employed individuals showing a significantly higher prevalence compared to other groups.
Conclusions: Our findings highlight the significant burden of depression and impaired QoL among vitiligo patients attending a tertiary care center. Addressing the psychosocial aspects of vitiligo alongside its dermatological manifestations is crucial for optimizing patient care and enhancing overall well-being. Further longitudinal research is warranted to elucidate the complex relationship between vitiligo and depression.
A KAP study on acceptance of millets in diet among housewives residing in a Military Garrison
Authors: Thorikonda Kartheek , Banerjee Indrayudh , Veer Prakash , Shyamsundar K. , Mehrotra Sameer , Sinha Subhralok
Published: June 2024

Background: Millets are a group of small-seeded grasses that are cultivated as food crops around the world especially in Africa and Asia. Millets have high fibre content which helps in better digestion and relief from constipation, high antioxidant activities and also helps to lower cholesterol. United Nations declared the year 2023 as International Year of Millets (IYoM-2023). Limited studies have been conducted on the Knowledge, Attitude and Practices (KAP) on acceptance to use millets in diet in our country. Consumption of millets was higher in the states of Gujarat, Karnataka, Maharashtra but negligible in the states of Kerala, Orissa, West Bengal and Tamil Nadu where rice is the most consumed cereal as opined by National Nutrition Monitoring Bureau. The objective of the study was to assess the acceptance of millets in diet among housewives residing in a Military garrison in West Bengal.
Methods: A cross-sectional study was carried out from 01 Aug 2023 and 15 Aug 2023 among housewives residing in a Military garrison in West Bengal.
Results: A total of 209 respondents participated in the study of which, 33% of the respondents belonged to 25-29 yrs age group. 52% of them were either graduates or post graduates. There is a significant (p<0.05) association between level of education and knowledge of health benefits of millets.
Conclusions: The Armed Forces have been the front runners in incorporating millets in their ration scale as clearly observed from our present study. Sustained efforts are required to create awareness and improve acceptance of use of millets amongst general population.
Necrotic loxoscelism in lower limb and reconstruction with skin autograft
Authors: Mauricio Leonel Iturbide , Lopez-Herrera Hugo E. , Perez-Puertos Josue I. , Rodriguez-Barrón Giovanni A. , Guerrero-Mercado Abigail
Published: June 2024

Loxesceles are small spiders, from 9 to 25 mm, with a dark brown spot on the dorsal part in the shape of an inverted violin. They are common in northwestern Mexico and can live at temperatures of 8 to 40°C. These spiders are considered of medical importance because their venom is dermonecrotic, with proteolytic and necrotic action, which is generated in two apocrine glands. The cutaneous clinical picture is the most frequent, with edema, erythema and ischemia that tends to evolve to ulceration and deep necrosis. The key to treatment is early debridement to avoid complications. We presented the case of a 57-year-old female patient who developed an inflammatory condition secondary to a fiddler spider bite involving the left lower extremity. Her evolution to necrosis and late diagnosis required surgical debridement and use of negative pressure therapy (VAC), followed by harvesting and placement of partial thickness skin autograft, obtaining a successful aesthetic and functional result.
Pott’s paraplegia-satisfactory outcome in spite of poor prognostic factors, treated by a novel surgical technique of posterior spinal stabilization and anterolateral decompression with bone graft fusion: a case report
Authors: Sarkar Rajib , Sarkar Samriddhi , Pramanik Atanu , Ali S. Imran , Mukherjee Somdeep
Published: June 2024

A case of Pott’s paraplegia of sudden onset and of more than two months duration in an aged female, treated by a novel surgical technique of anterior decompression and local kyphotic angle correction by spinal pedicular fixation is presented here. A 52 year female with Pott’s paraplegia, ASIA-A with sphincters involvement and with flexor spasm, was treated by surgical intervention, in a single operation of two stages, the first by provisional posterior pedicular fixation and the second stage by anterolateral decompression and correcting the local kyphotic angle by cyclic changing the rods in increments of 5 degrees in compressive mode. The paravertebral abscess of opposite side was sucked out and at the end a tricortical bone graft harvested from iliac crest was impacted in between the space created by pedicular fixation maneuver in course of correcting kyphosis. There was steady dramatic improvement of clinical and neurological status within three weeks. Kyphotic correction was maintained with anterior tricortical interbody bone graft impacted in position. The novel surgical technique that is adopted for decompression, drainage including paravertebral abscess of opposite side, debridement and local kyphotic angle correction along with interbody bone graft fusion, in this case, offered a satisfactory outcome in spite of poor prognostic factors.
A case report on anti-tubercular agent induced hepatotoxicity
Authors: Prasad Praveena R. , U. Ahalya , Dharan Shaiju S. , L. Drishya , Dharman Dhanya
Published: June 2024

Hepatotoxicity is the serious adverse effect of tuberculosis treatment and it leads to the discontinuation of Anti-tubercular agent (ATT) causing increased drug resistance, morbidity and mortality. We report a 69 years old male patient with ATT induced hepatotoxicity.
Modulating gut microbiota in the management of type 2 diabetes mellitus: a narrative review
Authors: Tousif Meirajuddin , Akhtar Maria
Published: June 2024

Type 2 diabetes mellitus (T2DM) represents a significant global health burden, necessitating innovative therapeutic approaches. Recent research has increasingly recognized the role of gut microbiota modulation in T2DM management, offering promising avenues for intervention. This systematic review synthesizes current literature investigating the impact of modulating gut microbiota on T2DM management. A comprehensive search of databases yielded studies examining various strategies, including probiotics, prebiotics, dietary interventions, and facal microbiota transplantation. Analysis of these interventions revealed their potential to improve glycemic control, insulin sensitivity, and inflammation markers in individuals with T2DM. Mechanistic insights elucidate how gut microbiota modulation influences metabolic pathways, immune function, and gut barrier integrity, thereby contributing to T2DM pathophysiology. Furthermore, studies highlight the interplay between gut microbiota composition and host factors such as diet, lifestyle, and genetics, underscoring the complexity of this relationship. Modulating gut microbiota presents a promising therapeutic approach in T2DM management, with potential benefits in glycemic control and metabolic health. However, further research is warranted to optimize intervention strategies, elucidate mechanistic pathways, and explore long-term effects. The aim of this review was to underscores the importance of considering gut microbiota modulation as a complementary approach in the multifaceted management of T2DM.