bluuebunny/crossref_metadata_2025 huggingface dataset:
#SPODF2024-CC6 Decisão de extração de um incisivo inferior – A propósito de um caso clínico tratado com alinhadores
Authors:   Instituto Universitário Ciências da Saúde, Teixeira Maria , Lencastre Carmo ,   Instituto Universitário Ciências da Saúde, Silva Inês ,   Instituto Universitário Ciências da Saúde, Vilarinho Adriano ,   Instituto Universitário Ciências da Saúde, Brito Maria ,   Instituto Universitário Ciências da Saúde
Published: January 2025

Introdução: A decisão de extração de um incisivo inferior não é consensual, no entanto pode ser considerada uma opção de tratamento com bons resultados em termos de função, estética e estabilidade. Além de poder reduzir o tempo de tratamento ortodôntico. A extração de um incisivo inferior pode ser indicada em pacientes sem crescimento, em casos de apinhamento moderado a grave dos incisivos inferiores, discrepância de Bolton por excesso mandibular, relação molar de Classe I ou Classe III suave bilateral, overject e overbite diminuídos, anatomia dos incisivos com forma retangular e perfil facial harmonioso. Descrição do caso clínico: Caso multidisciplinar de uma paciente adulta, hiperdivergente, oclusão topo a topo (overject e overbite de 0mm), DDM de 5mm, DDD de 3mm e forma retangular dos incisivos inferiores. Apresenta ausência de diversos dentes e um implante na região do dente 36. Foi efetuado um set up digital tendo indicação a exodontia do dente 41. As zonas edêntulas foram reabilitadas posteriormente. Discussão: Segundo a literatura na decisão de qual o incisivo inferior a extrair temos de considerar aspetos como: a presença de recessão gengival ou defeito periodontal, restauração extensa, largura mesiodistal, o tip e a sua localização em relação ao apinhamento. O dente mais próximo ao apinhamento e que está fora da arcada natural é frequentemente o mais indicado. No presente caso, optou-se por extrair dente 41. Em relação à mecânica utilizada para o fecho de espaço, foram utilizados attachments retangulares verticais convencionais nos dois dentes adjacentes ao espaço da extração. Para maior previsibilidade está indicada a sequenciação dos movimentos. Após 14 meses de tratamento ativo a paciente foi reabilitada e realizado um refinamento para ajustes finais. O tratamento resultou numa oclusão mutuamente protegida com Classe I canina. O overbite e overject foram normalizados. Na arcada mandibular a discrepância e apinhamento foram eliminados. As fotos finais mostram uma harmonia facial e sorriso agradável. Conclusões: Quando é indicada a extração de um incisivo inferior o uso de alinhadores com correta sequenciação dos movimentos pode ser considerada uma válida de tratamento. Sendo que nestes casos a realização de um set up digital permite uma maior previsibilidade do resultado.
#SPODF2024-CC7 Fiabilidade do diagnóstico dos defeitos ósseos vestibulares – Caso Clínico
Authors:   Egas Moniz School of Health and Science – Departamento de Ortodontia, Furão Susana , Ferreira Ana ,   Egas Moniz School of Health and Science – Departamento de Ortodontia, Pereira François ,   Egas Moniz School of Health and Science – Departamento de Ortodontia, Bugaighis Iman ,   Egas Moniz School of Health and Science – Departamento de Ortodontia, Costa Hélder ,   Egas Moniz School of Health and Science – Departamento de Ortodontia, Pereira Pedro ,   Egas Moniz School of Health and Science – Departamento de Ortodontia
Published: January 2025

Introdução: A identificação de alterações ósseas, como deiscências e fenestrações, é essencial durante o diagnóstico e planeamento ortodôntico. A avaliação da morfologia óssea pela observação clínica por norma é subestimada e a radiologia convencional apresenta limitações pela sobreposição de corticais contralaterais ou estruturas dentárias. O Cone Beam Computed Tomography (CBCT) proporciona uma visualização tridimensional desses defeitos com maior nitidez. Embora as imagens de CBCT sejam geralmente consideradas fiáveis, os estudos que examinaram a sua precisão verificaram que as mesmas subestimam a espessura da cortical óssea.O objetivo deste trabalho é comparar a precisão do diagnóstico de fenestrações e deiscências ósseas, por avaliação clínica, por CBCT e pela observação direta aquando de exposição cirúrgica, num caso onde foram realizadas corticotomias. Descrição do caso clínico: Paciente do sexo feminino, 55 anos, com padrão esquelético mesodivergente e normoclusão molar bilateral. Apresentava endognatia, discrepância dento-maxilar negativa bimaxilar e história de tratamento ortodôntico prévio. O tratamento ortodôntico foi coadjuvado com corticotomias, permitindo a observação direta de alterações ósseas e comparação com CBCT. Discussão: Uma prevalência elevada de falsos positivos quando comparamos os defeitos ósseos de imagens CBCT com observação direta são suportados pela literatura. São referidas duas possíveis justificações: a não visualização da cortical quando a sua espessura é inferior ao do corte das imagens obtidas e a semelhança de densidade entre osso e cemento. Metade dos casos de deiscências diagnosticadas através de CBCT são confirmadas na observação direta, enquanto as fenestrações só se verificam em um quarto dos casos.Neste caso clínico, as recessões gengivais pressupunham a existência de defeitos ósseos significativos, desaconselhando a expansão dentoalveolar. Após a visualização das imagens da CBCT, pensar-se-ia que o grau de deiscências nos caninos e incisivos laterais superiores seria muito próximo do comprimento do dente. No entanto, na visualização direta após o retalho muco-periósteo, verificou-se que os defeitos ósseos, apesar de significativos, não eram tão severos. Conclusões: A observação clínica é insuficiente na avaliação dos defeitos ósseos. A CBCT é um meio de diagnóstico importante, para a eventual visualização de defeitos ósseos, apesar das imagens encontradas poderem mostrar perdas maiores do que a realidade.
A Comprehensive Review of the Impact of Medications in Family Medicine on the Health of Pregnant Women and Children: Risks and Benefits
Authors: Alsudairy Najlaa , Alhijji Norah , Aljafar Bashayr , Alanazi Albandari , Alshaikh Sarah , Alsultan Danah , Hijab Zainab , Alshali Hawra , Aljumaan Sara , Alanazi Nujud , Aldhairyan Ahmad
Published: January 2025

The impact of medications on the health of pregnant women and their children is a critical area of concern in medical research and obstetrics. During pregnancy, women often require treatment for various health conditions, including chronic illnesses like diabetes, hypertension, and mental health disorders. However, the use of medications during this sensitive period can pose risks, as some drugs may cross the placental barrier and affect fetal development. Certain medications have been associated with adverse outcomes, including congenital malformations, preterm birth, and low birth weight. The balance between effectively managing maternal health and minimizing potential harm to the fetus necessitates careful consideration and consultation between healthcare providers and expecting mothers. Children's health can also be significantly impacted by maternal medication use during pregnancy, with possible long-term consequences. Research indicates that in utero exposure to specific medications may increase the risk of developmental delays, behavioral issues, and lifelong health concerns. For example, the use of antiepileptic drugs or antidepressants during pregnancy has been linked to neurodevelopmental disorders in offspring. It is essential for healthcare providers to closely monitor and assess the risk-benefit ratio of medications prescribed to pregnant women, emphasizing the importance of individualized treatment plans and informed decision-making. Moreover, adequate education on the safe use of medications during pregnancy can help mitigate risks and ensure healthier outcomes for both mothers and their children.
The Battle of the Atlantic, the “Air Gap,” and the Delay in Allocating Liberators to the Royal Canadian Air Force
Authors: Bell Christopher M.
Published: January 2025

The gravest crisis of the Battle of the Atlantic came in the latter part of 1942 and early 1943 when German submarine forces  concentrated in the central ocean, the “air gap” beyond the reach of shore based Allied maritime air forces. More capable aircraft  were available, but not assigned to the maritime role until the spring of 1943. This article proposes a new methodology for understanding the reasons for the delay by examining the complex interactions among the navies, air forces, and politicians of the  three Allied powers primarily responsible for trade defence in the Atlantic Ocean – Great Britain, the United States, and Canada –  and exploring the special difficulties faced by the Royal Canadian Air Force.
A assinatura: aspectos otobiográficos na poesia de Marcos Siscar
Authors: Oliveira Maria Eduarda Cesar de , Cintra Elaine Cristina
Published: January 2025

No estudo aqui proposto, discutimos alguns aspectos autobiográficos na poesia de Marcos Siscar a partir do conceito derridiano “otobiografia”, o qual pressupõe que todo texto possuiria traços que refletem a autoria. Para isso, analisamos um dos elementos da otobiografia, a assinatura, em dois poemas de Siscar, “São Paulo 1972” (2003) e “Cuspindo contra o vento” (2019), períodos distintos em que o poeta escolheu como recurso estético a data para discutir o contexto do autor empírico e, conforme a discussão derridiana, apesar de não trazerem objetivamente dados da vida pessoal do autor, assumem pelo ato de escrita circunstâncias de sua realidade.
Total Physical Response (TPR) Method in Teaching English Classroom Interaction for Young Learners
Authors: Jayanti Sri , Rachmawati Etika
Published: January 2025

This paper focused on the TPR method as a learning media for English as a foreign language to young learners. This study was designed to investigate the teachers’ experience in using the TPR method as a means of teaching English to young learners. The research design of this study was a narrative inquiry and the participant of this study was an English teacher at one of the non-formal education institutions in Ciamis. The subject of this research were students and an English teacher in non-formal education Ciamis. The data collection included classroom observation and semi-structured interviews. The results of the study found that the TPR method had a positive influence as a means of learning English as a foreign language, particularly when the teacher teaches vocabulary. From the five-question indicators, it can be concluded that the TPR method is also quite effective to be applied as a learning medium for young learners since young learners have a good memory to input the vocabulary that is being taught. Moreover, it is easier for the teacher to provide learning students’ enthusiasm for learning clearly appears that makes the class not boring.
An Analysis of Teacher and Students’ Talk in their Online Public Speaking Class Interaction Via Zoom Cloud Meeting (Qualitative Research)
Authors: Nurfitriani Ine , Faridah Didih , Rohayati Dedeh
Published: January 2025

The phenomena of Covid-19 challenges the government in carrying out the classroom activity; for this reason, the government issued a policy to change studying activities which are commonly achieved in the classroom into studying from home throughout the Covid-19. This research discusses teacher and students’ talk in their online public speaking class interaction via zoom cloud meeting. The purpose of this study was aimed to find out the types of teachers and students chatting in their online interaction via zoom cloud meetings, the types of classroom interaction in public speaking class via zoom cloud meetings, and to find out students’ perceptions toward their teacher talk through zoom cloud meeting. The present study used a qualitative paradigm with the type of  intrinsic case study. Thirteen students from a 2C public speaking class in an English education program, and an English lecturer participated in this research. The data taken from observation aims to find out types of teacher and students talk in public speaking class via zoom cloud meeting, and types of classroom interaction in public speaking class. Meanwhile, a set of questionnaires was employed to collect data about the students’ perceptions toward their teacher talk through zoom cloud meeting. The data from observation were proceeded by means of FLINT System to interpret teacher and students' talk; regarding the type of classroom interaction was adapted from Malamah-Thomas (1987 as cited in Alifea Asanuary Sharliz, 2017). The questionnaire data were analyzed using the Likert Scale measurement. The findings revealed that the types of teachers and student talk and the types of classroom interaction that occurred in class 2C were dominated by the teacher talk. Although students prefer to talk a lot in class, the results of this study indicated that the teacher talks more in class. The researcher suggests for the public speaking teacher to make changes in classroom activity for the coming semester, i.e., the teacher facilitates students to talk a lot during the process of teaching and learning.
Enhancing Student’s Persuasive Writing Achievement Using Internet Meme Pictures
Authors: Jihad Naufal Ibnu , Rustandi Andi , Tarwana Wawan
Published: January 2025

The purpose of this study was to investigate whether or not: (1) there was a significant difference in Persuasive Writing achievement among the eleven grade students of one high school in Calipari Cilacap, Central Java was taught by using internet meme pictures and (2) there was no significant difference in Persuasive Writing achievement between the students who were treated using internet meme pictures and those who were not. There were 40 students of XI MIPA 1 and XI MIPA 2 as the sample of this study. In data collection, each group was treated with a pre-test and post-test of writing. The data were processed using Paired Sample t-test and Independent Sample t-test in SPSS version 35. The results of Paired Sample t-test revealed that there was a significant difference in Persuasive Writing achievement before and after students were taught using the internet Meme Pictures. The result from the dependent Sample t-test of the post-test in both experimental and control groups revealed that there was a significant difference in Persuasive Writing achievement between the students who were treated using Internet Meme Picture and those who were not as the P-value both of Paired Sample t-test and Independent Sample t-test results were lower than 0.05 (0.000 < .05).
EFL Students’ Perceptions on the Use of Quillbot Paraphrasing Tool in Essay Writing
Authors: Nuraeni Ayu , Febriani R. Bunga , Rustandi Andi
Published: January 2025

This research discusses about EFL Students’ Perceptions On The Use Of Quillbot Paraphrasing Tool In Essay Writing. The objective of this study was aimed to elaborate on how EFL students implement the QuillBot Paraphrasing Tool in essay writing and EFL students perceive of use the QuillBot Paraphrasing Tool in essay writing. This study used a descriptive qualitative method, involved 25 students’ of English Education who used QuillBot Paraphrasing Tool In Essay Writing. Brief rating scales questionnaires were used to gather the data. The results showed that students responded positively to the use of the QuiillBot Paraphrasing Tool In Essay Writing. Most students agree that using QuillBot makes the process of paraphrasing in writing easier and more efficient. QuillBot can help students paraphrase and avoid plagiarism in their writing. While this tool is powerful, Quillbot may be a useful tool for EFL students, but it's important to remember that it shouldn't be overly relied on. Students should continue to concentrate on improving their paraphrasing skills while using Quillbot to complement their endeavors and students should use it wisely. The researcher suggests that future researchers are expected to be able to examine more sources and references related to paraphrasing using QuillBot.
Usage of Fragrances in Agriculture: Insights from “Gyuhap Chongseo”, “Sangarak”
Authors:   Korea National University of Heritage Buyeo, Republic of Korea, Ha Sumin
Published: January 2025

“Gyuhap Chongseo”, compiled by Yi Bingheogak in 1809, is an encyclopedia of household management by a Joseon dynasty noblewoman. This study explores the use of fragrances in agriculture, particularly in the “Sangarak” section. It
reveals how fragrances were employed for rituals, medicine, insect repellent, and
deodorization. Yi Bingheogak’s work reflects the practical application of traditional
knowledge, emphasizing women’s active roles in managing household and agricultural practices.
The Capital of Xinjiang Urumchi in RussianChinese Relations at the Second Half of the 19th Century
Authors:   Siberian Federal University Krasnoyarsk, Russia, Datsyshen Vladimir G.
Published: January 2025

The Xinjiang Uyghur Autonomous Region plays a significant role in the
dynamics of Russian-Chinese relations. The modern relationship between these
two countries is rooted in a rich historical context. Xinjiang has been a border area
with Russia since the establishment of this administrative unit within the Chinese
Empire. The latter half of the 19th century and the first half of the 20th century
were particularly complex and eventful for the region, while the late 19th to early
20th centuries witnessed a period of relative stability in relations between Russia
and China. Researchers focusing on the history of Russian-Chinese interactions in
Xinjiang have primarily concentrated on the border counties in the western part of
the region. However, it is crucial to consider the administrative center of Xinjiang,
Urumqi, and examine its significance and role in the broader context of RussianChinese relations.
From the History of VOCS Developing Contacts with China in the Field of Education in the 1930s
Authors:   Institute of China and Contemporary Asia RAS Moscow, Russia, Verchenko Alla L.
Published: January 2025

The article is devoted to the activities of the USSR Society for Cultural
Relations with Abroad (VOKS) on the expansion of the Soviet-Chinese cooperation
in the field of education in the 1930s. The study was conducted on the basis of documents of the State Archive of the Russian Federation, the distinctive feature of
which was a stamp “not subject to disclosure”. The documents show the interest of
Chinese educators in the experience of the USSR and recognition of the success of
the USSR in the sphere of education. VOKS played a key role in hosting the reception of Chinese educators, prepared the program of stay of guests, provided them
with support during their visits to educational institutions, for which it earned the
positive evaluation of many Chinese guests.
Diagnóstico diferencial de lesões odontogênicas: Relato de caso
Authors: Nunes Bruna Quele Batista , Brito Diele Guimarães , Santos Emyli Vieira dos , Dias Filipe Gonçalves , Guedes Matheus Augusto Lima , Almeida Paloma Barbosa , Rocha Thainara Lima Canguçu da , Lopes Mylena da Silva , Silva Yuri Slusarenko Da , Melo Maria José Lopes de
Published: January 2025

Objetivo: Relatar um caso clínico que estabelece o diagnóstico diferencial de lesões odontogênicas, enfatizando os critérios diagnósticos utilizados para a exclusão ou confirmação dessas condições, visando oferecer uma abordagem de tratamento efetiva e de excelência. Detalhamento do caso: Paciente do sexo masculino, 9 anos,  apresentou aumento de volume em região anterior da mandíbula, com mobilidade dentária, ausência do elemento 43, todavia, sem sintomatologia dolorosa. Na radiografia panorâmica, foi identificada uma lesão radiolúcida extensa, delimitada, envolvendo o deslocamento do dente 43 para região inferior da mandíbula. Para o diagnóstico diferencial, foi realizado exame histopatológico. A histopatologia desempenha um papel crucial no diagnóstico diferencial de lesões maxilofaciais, especialmente em casos onde as características clínicas e radiográficas são similares.  A análise histopatológica permite descartar algumas condições, sendo fundamental para refinar o diagnóstico e direcionar o tratamento de forma mais eficaz. Considerações finais: Os cistos dentígero, queratocistos e odontomas complexos, representam lesões odontogênicas com características clínicas e radiográficas muito similares, sendo imprescindível a realização de exames histopatológicos. Essa diferenciação é essencial para evitar diagnósticos incorretos e tratamentos inadequados, uma vez que cada lesão possui um potencial patogênico e uma resposta terapêutica distintas.
Single-stage revision anterior cruciate ligament reconstruction for anatomic, massive dilated tunnels using “the sandwich technique”
Authors: Thonse Chirag , Paul Dhruv , Shukla Shreyansh , Shetty K Deekshith
Published: January 2025

At present, revision anterior cruciate ligament reconstruction (ACL-R) with dilated tunnels is managed as a two-stage procedure which results in longer recovery and rehabilitation as well as late return to sports. In the present “sandwich” technique, management of revision ACL-R with dilated tunnels can be carried out as a single-stage procedure, which basically entails sandwiching the tibia end of bone patellar tendon bone graft in between the allograft and the tibial tunnel. The present case highlights the use of a novel technique coined as the “sandwich technique” for managing revision ACL-R in a 38-year-old male with dilated femoral and tibial tunnels which is usually managed through staged procedures. Single-stage “sandwich technique” is a viable option in managing revision anterior cruciate ligament scenarios with massive, dilated tunnels, thus decreasing the morbidity, mental agonies, and financial obligations associated with an additional procedure.
Применение сварочной проволоки различных диаметров при изготовлении металлоконструкций
Authors: Малых Н.В. , Беляева З.В.
Published: January 2025

В статье рассмотрено противоречие между выбором сварочных материалов для механизированной сварки, предписываемых нормами проектирования, и фактическим положением в отрасли изготовления стальных конструкций. В действующих нормах указаны диаметры и марки сварочной проволоки, которые отсутствуют на заводах металлоконструкций. Исследование показывает несовершенство некотрых пунктов действующих норм и создает основу для проведения серии экспериментов для последующей переработки нормативной базы.

The article examines the contradiction between the choice of welding materials for mechanized welding prescribed by design standards and the actual situation in the steel structure manufacturing industry. The current standards specify diameters and grades of welding wire that are not available at metal structure plants. The study shows the imperfection of some points of the current standards and creates the basis for conducting a series of experiments for the subsequent revision of the regulatory framework.
Muynak’s Aral Sea museums: Design as a Factor of Place Making
Authors: Georgoutsi I. , Bystrova T.
Published: January 2025

The article presents data from a field study of the local history museum in Muynak (Uzbekistan) near the Aral Sea and State Museum of Arts named after I. V. Savitsky. Museum design is considered as a factor in enhancing the attractiveness of a museum for visitors (including tourists) in a place located in difficult climatic, ecological and socio-economic conditions. The aim of the text is to suggest and give examples about the implementation of a modern ad visitor friendly design and exhibition facilities which in combination with digital exhibition technology will aid both institutions to complete their vision and mission, contribute to the place development.

В статье представлены данные полевого исследования краеведческого музея в Муйнаке (Узбекистан) недалеко от Аральского моря и Государственного музея искусств им. И. В. Савицкого. Музейный дизайн рассматривается как фактор повышения привлекательности музея для посетителей (включая туристов) в месте, расположенном в сложных климатических, экологических и социально-экономических условиях. Цель текста - предложить и привести примеры внедрения современного дружественного к посетителям дизайна и экспозиционного оборудования, которые в сочетании с цифровыми технологиями экспонирования помогут обоим учреждениям реализовать свое видение и миссию, способствовать развитию места.
Трансформация изготовления традиционной якутской одежды в конце XIX ‒ ХХ вв.: ручной труд и фабричное производство
Authors: Федорова А.Р. , Ларионова А.С.
Published: January 2025

В исследованиях традиционного костюма процесс его производства как социокультурное явление остается недостаточно раскрытым. В статье через призму историко-антропологического подхода рассматривается трансформация локального производства одежды в Якутии в конце XIX – ХХ вв. Для достижения этой цели привлечены разрозненные этнографические сведения, представленные в научной литературе, архивных документах и музейных коллекциях, а также собственные полевые материалы автора. В результате проведенного исследования установлено, что именно сохранение практик локального производства одежды способствовало тому, что традиционный якутский костюм продолжает оставаться востребованным в повседневной жизни.

In the issues of studying traditional costume, the very process of production as a socio-cultural phenomenon has previously been poorly studied. The article examines the changes in local production of clothing in Yakutia in the late 19th – 20th centuries from the point of view of historical and anthropological approach. To achieve this aim, ethnographic, archival and field materials are involved, with the help of which the everyday experience of the population of providing themselves with clothes during the period of modernization processes was considered. In the second half of the 20th century, localized clothing production developed in two vectors: home and factory production. The character and appearance of the products of these two directions demonstrates the influence of authorship on the appearance of costume and on the way traditions are reproduced. The article reveals that it was the practices of preserving home production of clothes and local production that contributed to the preservation of Yakut traditional costume in everyday life.
Исторические драмы Э. Радзинского как текстовое единство
Authors: Александрова И.В.
Published: January 2025

Исторические драмы Э. Радзинского анализируются в аспекте проблемы сверхтекста, в частности, такого его типа, как текстовое единство, представленное одной из его разновидностей – несобранным (рецептивным) циклом. В числе циклообразующих свойств пьес Э. Радзинского выявлены общность их проблемно-тематического комплекса, конфликта, типов героев, сходство принципов воплощения пространственно-временного континуума, наличие системы сквозных мотивов, автореминисценций, художественной условности как авторской стратегии, жанрово-стилистических черт и общей модальной установки. Эти свойства побуждают к восприятию отдельных пьес как структурных компонентов единого целого, ядром которого является авторский идейно-художественный вектор.

The historical dramas of E. Radzinsky are analyzed in the aspect of the problem of supertext, in particular, as a type of textual unity. It is represented by one of its varieties – an uncollected (receptive) cycle, that is, a corpus of texts that have a number of unifying structural, semantic and stylistic features while maintaining the autonomy of individual works, the compositional correlation of which is not determined by the author. Among the cycle-forming properties of E. Radzinsky’s plays, the commonality of their problem-thematic complex, conflict, types of heroes, the similarity of the principles of embodiment of the space-time continuum, the presence of a system of cross-cutting motives, auto-reminiscences, artistic conventions as an author’s strategy, genre and stylistic features and a general modal setting were identified. The presence of these properties encourages the perception of separate plays as structural components of an indivisible interrity, the core of which is the author’s ideological and artistic vector. The paradigmatic relationships between the works in the cycle and the increments of meaning in each subsequent play are revealed, ensuring the internal dynamics of the textual unity and its logic.
A role for mitochondria–ER crosstalk in amyotrophic lateral sclerosis 8 pathogenesis
Authors: Wilson Cathal , Giaquinto Laura , Santoro Michele , Di Tullio Giuseppe , Morra Valentina , Kukulski Wanda , Venditti Rossella , Navone Francesca , Borgese Nica , De Matteis Maria Antonietta
Published: January 2025

Protein aggregates in motoneurons, a pathological hallmark of amyotrophic lateral sclerosis, have been suggested to play a key pathogenetic role. ALS8, characterized by ER-associated inclusions, is caused by a heterozygous mutation in VAPB, which acts at multiple membrane contact sites between the ER and almost all other organelles. The link between protein aggregation and cellular dysfunction is unclear. A yeast model, expressing human mutant and WT-VAPB under the control of the orthologous yeast promoter in haploid and diploid cells, was developed to mimic the disease situation. Inclusion formation was found to be a developmentally regulated process linked to mitochondrial damage that could be attenuated by reducing ER–mitochondrial contacts. The co-expression of the WT protein retarded P56S-VAPB inclusion formation. Importantly, we validated these results in mammalian motoneuron cells. Our findings indicate that (age-related) damage to mitochondria influences the propensity of the mutant VAPB to form aggregates via ER–mitochondrial contacts, initiating a series of events leading to disease progression.
Estimated solar energy potential in Mangystau oblast
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Mendybayev Yerbolat , Berdenov Zharas , Tankibayev Timur , Almurzayeva Saltanat , Muratov Ruslan , Zhumagul Moldir
Published: January 2025

The paper describes a study on the potential of solar energy in Mangystau oblast. This paper presents maps of solar radiation arrival kWh/m2/day by key months: January, April, July, October and for a year. A calculation of the solar energy potential, which can be received by the PV module for a year of opera-tion in Mangystau region, near the city of Aktau, was carried out. The results obtained give an idea of the solar radiation arrival on the vertical surface. The results of the study can be used for further, more in-depth calculations of the arrival of solar radiation, not only for Mangystau region, but also for other regions where there is a potential for solar energy generation. Test calculations showed good agreement with those presented in the literature.
Penerapan Slow Deep Breathing Untuk Menurunkan Tekanan Darah Pada Lansia Hipertensi
Authors: Ilma Zidha' , Aisah Siti
Published: January 2025

Kasus hipertensi merupakan masalah kesehatan yang besar dan banyak ditemukan pada lansia. Apabila tidak diketahui sejak dini dan segera ditangani maka dapat memicu komplikasi penyakit lainnya. Penatalaksanaan hipertensi dapat dilakukan menggunakan slow deep breathing. Tujuan studi kasus ini untuk mengetahui penurunan tekanan darah pada lansia hipertensi dengan terapi slow deep breathing. Studi kasus ini menggunakan desain deskriptif dengan pendekatan proses asuhan keperawatan dengan pemberian slow deep breathing 15 menit dengan frekuensi dua kali sehari selama 4 hari yang diterapkan pada 2 lansia perempuan dengan hipertensi tipe 1 dan terkontrol obat antihipertensi. Hasil studi kasus ini menunjukkan rerata tekanan darah pagi kedua klien sebelum terapi 144,5/95 mmHg, sesudah terapi menjadi 142/92,5 mmHg, serta sebelum terapi rerata tekanan darah sore kedua klien 140,5/91,5 mmHg, sesudah terapi menjadi 137,5/90,5 mmHg. Kedua klien mengalami penurunan rerata tekanan darah sistolik pagi kedua klien 2,5 mmHg dan tekanan darah sistolik sore kedua klien 3 mmHg. Sedangkan rerata penurunan tekanan darah diastolik pagi kedua klien 2,5 mmHg dan tekanan darah diastolik sore kedua klien 1 mmHg. Berdasarkan hasil studi kasus ini dapat  disimpulkan slow deep breathing dapat menurunkan tekanan darah 2 lansia hipertensi. Diharapkan slow deep breathing dapat diaplikasikan masyarakat untuk menurunkan tekanan darah.
Advancements in Nanorobots: Innovating Bladder Cancer Treatments, Diagnosis and Patient Outcomes
Authors: Hussain Zehra , Di Fonzo Alyssa , Merhawi Hermela , Gallant Mary , Girlan Robert , Hasibul Hasan Muhammad
Published: January 2025

Nanorobots are an emerging technology that can deliver cancer treatment with increased precision, potentially decreasing unintended side effects commonly seen with surgery, chemotherapy, and radiation therapy. Recent advancements in in vivo trials have demonstrated significant tumor reduction in mice with bladder cancer, showing the potential of nanorobots to not only treat but also improve diagnostic capabilities in cancer therapy. This review aims to highlight the precision of nanorobots, the current knowledge on their use and their potential in clinical applications. The use of nanorobots could lead to better patient outcomes by providing targeted treatment and reducing side effects. Key components of modern nanorobot technology, including self-driving capabilities, biocompatibility, and biosafety, are analyzed. Chemically-driven micro/nanorobots (MNRs) are primarily categorized by the biocompatibility of the materials used and the cytotoxicity of their waste products. Common materials are considered, focusing on size, shape, surface charge, and surface area. While both hydrogen peroxide and urease-driven nanorobots are considered potential fuels for MNRs, urease is regarded as a more biocompatible solution, making it a promising option for cancer treatment. This report emphasizes the potential of nanorobots to revolutionize the treatment of bladder cancer by improving both therapeutic precision and patient quality of life.
Estimation of gamma distribution parameters
Authors: Orlov A.
Published: January 2025

Statements of problems of statistical analysis of data with a gamma distribution are related to classical mathematical statistics. Oddly enough, not all alone were solved within the framework of parametric statistics, which was at the forefront of the development of statistical science in the first third of the 20th century. As with the beta distribution, gaps need to be filled. This is necessary because the gamma distribution is currently widely used in theoretical and applied work. An example is GOST 11.011–83 «Applied statistics. Rules for determining estimates and confidence limits for gamma distribution parameters». The standard gamma distribution is determined by the shape parameter. When switching to a scale-shift family, scale and translation parameters are added. Seven formulations of parameter estimation problems are considered, since each of the three parameters can be either unknown or known. For each of the formulations, the estimates of the method of moments and their asymptotic variances are found. For a known shift parameter, maximum likelihood estimates are obtained. One-step estimates, asymptotically equivalent to maximum likelihood estimates, are used for an unknown shift parameter. The presence of measurement errors affects the accuracy of parameter estimates when applying certain calculation algorithms. In GOST 11.011–83, based on the interval data model, rules are given for choosing an estimation method for unknown shape and scale parameters and a known shift parameter. During the development of GOST 11.011–83, problems were identified, for the solution of which new methods from a scientific point of view were proposed. Further development of new scientific results obtained in the course of solving a practical problem (development of GOST 11.011–83) led to the creation of new scientific directions. We are talking about the statistics of interval data, as well as one-step estimates. To date, the statistics of interval data as a branch of mathematical statistics is quite developed and covers all the main areas of statistical methods. It is an important part of systemic fuzzy interval mathematics.
Some properties of almost all n-quasigroups
Authors: Galatenko A. V. , Galatenko V. V. , Pankratiev A. E.
Published: January 2025

We study the generic nature of simplicity, non-affinity and polynomial completeness of finite n-quasigroups. It is shown that for fixed n almost all n-quasigroups are strongly non-affine, i.e., not isotopic to affine n-quasigroups. Exact number of simple, affine and simultaneously simple and affine n-quasigroups of the order 4 is established. As a corollary, it is proven that almost all n-quasigroups of the order 4 are polynomially complete and strongly non-affine.
Alternative replacement option for medium-span bridge with the Hybrid Decked Bulb Tee
Authors: Agüero Barrantes Pablo , Hain Alexandra
Published: January 2025

Increasing the service life of bridges has become a critical requirement in modern times. To address this need, new materials and technologies are essential, for example Ultra High-Performance Concrete (UHPC). This paper introduces the Hybrid Decked Bulb Tee (HDBT) beam, an advancement in prefabricated construction that employs a combination of prestressed UHPC and non-prestressed High-Performance Concrete (HPC). By implementing a staged construction process, the HDBT beam effectively reduces beam-end cracking commonly observed in traditional prestress construction methods. To justify the structural reliability of the HDBT, this paper presents an analytical investigation based on state-of-the-art research. The results demonstrate that the HDBT beam is a feasible option for bridge rehabilitation projects, offering enhanced performance and extended service life.
Boosting Design Efficiency by using BIM for a Major Railway Project in Nigeria
Authors: Duarte Jose R. , Fernandes Bruno , Gonçalves Luís , Devedzic Zeljka , Stampler Johann
Published: January 2025

The new railway line from Kano in northern Nigeria to Maradi in Niger, with a secondary line from Kano to Dutse, is a challenging project due to its enormous size spanning some 400 km and requiring the construction of 20 railway stations, 5 maintenance yards and workshops, 53 railway bridges, 86 road overpasses, and 7 road underpasses. The Portuguese consulting company Quadrante is responsible for preliminary and detailed design. It comprehensively uses BIM techniques to perform this huge task in a timely manner. Following the motto “Standardization = Efficiency”, an overall infrastructural BIM model for the complete project including stations, bridges, overpasses, and underpasses etc., was developed. The paper shows the adopted BIM techniques which allowed to considerably enhance the design works and to reach the goal of executing the project with maximum efficiency and in accordance with time constraints and accuracy demands.
Analytical study on increasing slip strength of high-strength threaded stud-welded frictional joint with inorganic zinc-rich painted surface for a thin steel plate
Authors: Kiyama Taisei , Yamaguchi Takashi , Okamoto Masaki , Okuhara Hiroto , Ishikawa Makoto , Yoshida Kenji
Published: January 2025

The authors are studying a steel concrete composite slab joint structure improving workability by applying high strength stud bolts. The bottom steel plate is 6mm steel plate, which limits the axial force that can be introduced by the stud bolts to about half that of high-strength bolts. Consequently, compared to the high-strength bolt friction joint, the number of bolts increase, potentially affecting bolt placement and construction. We focused on the tendency of friction coefficient to increase with decreasing contact pressure when the joint surface treatment is inorganic zinc. In this study, FEM was conducted to increase the slip load by cutting around the bolt hole wall on the top side of the splice plate. The results have been shown that the contact area increased and the contact pressure decreased as the splice plate cloud follow the deformation of the main plate. It is also concluded that the cutting the edge of the bolt hole wall of the splice plate improved slip load.
Viaduct Solutions for Unstable Slopes in the Kicking Horse Canyon
Authors: McIlwain Sam , Hamersley Bruce , Wu William , Wang Tian
Published: January 2025

This paper presents an innovative viaduct solution using accelerated bridge construction techniques crossing a series of unstable slopes, active landslides, and avalanche and rock fall paths along a treacherous highway section of the Kicking Horse Canyon Phase 4 project in British Columbia, Canada. The utilization of compact precast concrete components significantly minimized on-site labour requirements, improved the constructability, and reduced the construction schedule and cost. Approximately 1.8 km of viaduct structures were designed to span the unstable soils. Significant loads from avalanches and landslides were imposed on the viaducts. The piled foundations were designed to resist the loads as soil failed around the piles during a landslide, rather than fully stabilize the slopes. A unique “drift-link” detail connected the piles to the pier caps to accommodate thermal movement, as well as provide load-sharing between piles for lateral loads.
Technical rehabilitation and strengthening of the Chemnitz viaduct
Authors: Stroetmann Richard , Oertel Steffen , Fuchs Alexander
Published: January 2025

The Chemnitz viaduct, which was built between 1901 and 1909 for a four-track operation, was tech- nically refurbished and reinforced for modern use in accordance with the requirements of the his- torical monument preservation. The two inner tracks will be used for future railway traffic, while the outer bridge structures will accommodate inspection, maintenance and emergency routes as well as technical equipment. The approx. 275 m long and 17.50 m wide bridge consists of 2 arch and 10 girder segments. During the technical repair, the inner girder segments were renewed as a steel- concrete composite structure. The other structures were repaired, strengthened and supplemented with a reinforced concrete structure above the curved steel sheet. This article begins with an over- view of the existing bridge structure and its future use. This is followed by explanations of the plan- ning and execution of the construction work.
NDT assessment of pylon foundations of the Swiss power grid
Authors: Brenni Pietro , Moor Gianni , O’Suilleabhain Colm
Published: January 2025

This paper describes a project to assess the condition of the concrete foundations of the electricity pylons of two lines of Switzerland’s extra-high-voltage transmission grid. The solution proposed by the engineering firm involves the use of high-tech non-destructive testing (NDT) equipment and a future-oriented “asset management” approach to the storage, management and sharing of data on a cloud-based platform. This solution demonstrates how such technology can optimize the long- term maintenance of structures and infrastructure – especially in the case of multi-asset networks.
BIM Basics in an International Context
Authors: Seitz Peter
Published: January 2025

Building Information Modelling (BIM) is all the rage these days, but hardly anyone understands what it really means. Even internationally, BIM has different meanings. The BIM method is important for future construction projects, so we need to know how BIM is understood in an international context.

This paper briefly outlines BIM's origins, followed by a definition of its meaning. For some countries, it shows which organization is responsible for the BIM definitions and which initiatives exist to inform about the application of BIM. Some terms and abbreviations that are important when working with BIM are explained. Use cases are explained, and a reference to software tools is given.

This paper will help people and organizations start using the BIM method for everyday use. The BIM method is only one part of the digitalisation process in the construction industry, but it can help organize information and implement an efficient way of collaboration with different disciplines.
Resilience of transport infrastructure against natural hazards: attributes and indicators
Authors: Karagiannakis George , Giordano Pier Francesco , Limongelli Maria Pina
Published: January 2025

The surge in extreme weather globally inflicts extensive damage to transport infrastructure, resulting in high costs for restoration and long-term recovery. Resilience management, encompassing different phases - from pre- to post-disaster - is crucial for enhancing robustness, reducing recovery time, mitigating losses, and adapting to climate extremes. Existing literature extensively addresses some attributes of resilience, especially robustness and recovery capacity, which affect direct and indirect losses due to a disruptive event. Other attributes such as preparedness and adaptive capacity, which affect resilience management in the phase before the next or future disruptions, have received less attention. This study identifies indicators to describe and manage the resilience of transport assets across all management phases, also introducing the phase "beyond" recovery. The paper also introduces “intelligence” which is associated with the capacity of a system to use information to support resilience management “across” all the other phases.
Fatigue assessment of a long-span suspension bridge with an orthotropic deck in aluminium
Authors: Villoria Bruno , Siriwardane Sudath C. , Bogunović Jakobsen Jasna
Published: January 2025

A novel grain scale plasticity-based approach for multiaxial fatigue life assessment is introduced to evaluate the fatigue life of friction stir welded (FSW) joints of the aluminium orthotropic bridge girder of a long-span suspension bridge. The proposed method is validated using multiaxial fatigue tests on FSW specimens and random variable amplitude uniaxial loading tests on FSW and MIG welded joints. A framework for simulating the combined effect of stochastic traffic and wind loading on the considered suspension bridge is presented and the fatigue lives of eight selected details are calculated using the nominal stress, the critical plane method and the proposed grain scale plasticity-based model. The critical plane method provides the shortest fatigue life while the proposed model predicts the longest fatigue life, aligning with the findings from the experimental data used for validation of the proposed model.
Resource expenditure for bridges in Sweden – do we build greener bridges now compared to 50 years ago?
Authors: Björnsson Ivar , Thelandersson Sven , Kamrad Thomas , Lundstedt Karl , Öhrström Ola
Published: January 2025

The building and construction sector is responsible for a significant portion of embodied and energy related carbon emissions. Efforts to reduce this are reflected in the need for improved sustainability in the design, construction, and operation of structures such as buildings and bridges. This issue has become more prominent in recent decades due to the ongoing climate crisis. A historical review of developments in bridge design and construction reveals an evolution in procedures, codes, and practices. The aim was often to improve something; reduce costs, reduce conservatism, optimize structural configurations, increase safety, improve durability, etc. Significant developments over the previous half century have included the now ubiquitous use of more advanced computational software and the growth in both size and complexity of design codes. A relevant question concerns how these types of developments have impacted sustainability; do we build greener than 50 years ago? This paper discusses this issue for the case of bridge construction in Sweden, where an increase in material expenditure, costs, and environmental impacts have been observed when comparing newer and older bridges. Case studies of existing bridges are provided as examples highlighting potential driving forces for the observed increases. As it stands, it is unclear whether, and to what degree, these increases are justified. Industry perspectives, obtained from interviews with bridge experts, confirm the observed trend and some of the causes for the increase. Possible strategies for dealing with this problem are discussed, highlighting the need for further action.