bluuebunny/crossref_metadata_2025 huggingface dataset:
MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women
Authors: Cho Hye-Won , Jin Hyun-Seok , Eom Yong-Bin
Published: March 2021

Osteoporosis, characterized by reduced bone mass and increased bone fragility, is a disease prevalent in women. Likewise, breast cancer is a multifactorial disease and considered the major cause of mortality in premenopausal and postmenopausal women worldwide. Our data demonstrated the association of the MYLK gene and PTGS1 gene variants with osteoporosis and benign breast tumor risk and the impact of ovariectomy on osteoporosis in Korean women. We performed a genome-wide association study (GWAS) of women with osteoporosis and benign breast tumors. There were 60 single nucleotide polymorphisms (SNPs) and 12 SNPs in the MYLK and PTGS1 genes, associated with benign breast tumors and osteoporosis. Our study showed that women with homozygous MYLK rs12163585 major alleles had an increased risk of osteoporosis following ovariectomy compared to those with minor alleles. Women carrying the minor PTGS1 rs1213265 allele and not treated via ovariectomy carried a higher risk of osteoporosis than those who underwent ovariectomy with a homozygous genotype at the major alleles. Our results suggest that both the MYLK and PTGS1 genes are genetic factors associated with the phenotypes, and these associations appear to be modulated by ovariectomy.
Identification of Imprinted Genes Based on Homology: An Example of Fragaria vesca
Authors: Liu Yaping , Jing Xiaotong , Zhang Hong , Xiong Jinsong , Qiao Yushan
Published: March 2021

Genomic imprinting has drawn increasing attention in plant biology in recent years. At present, hundreds of imprinted genes have been identified in various plants, and some of them have been reported to be evolutionarily conserved in plant species. In this research, 17 candidate genes in Fragaria vesca were obtained based on the homologous imprinted genes in Arabidopsis thaliana and other species. We further constructed reciprocal crosses of diploid strawberry (F. vesca) using the varieties 10-41 and 18-86 as the parents to investigate the conservation of these imprinted genes. Potentially informative single nucleotide polymorphisms (SNPs) were used as molecular markers of two parents obtained from candidate imprinted genes which have been cloned and sequenced. Meanwhile, we analyzed the SNP site variation ratios and parent-of-origin expression patterns of candidate imprinted genes at 10 days after pollination (DAP) endosperm and embryo for the hybrids of reciprocal cross, respectively. A total of five maternally expressed genes (MEGs), i.e., FvARI8, FvKHDP-2, FvDRIP2, FvBRO1, and FvLTP3, were identified in the endosperm, which did not show imprinting in the embryo. Finally, tissues expression analysis indicated that the five imprinted genes excluding FvDRIP2 mainly expressed in the endosperm. This is the first report on imprinted genes of Fragaria, and we provide a simple and rapid method based on homologous conservation to screen imprinted genes. The present study will provide a basis for further study of function and mechanism of genomic imprinting in F. vesca.
Geochemical, Geological and Groundwater Quality Characterization of a Complex Geological Framework: The Case Study of the Coreca Area (Calabria, South Italy)
Authors: Vespasiano Giovanni , Muto Francesco , Apollaro Carmine
Published: March 2021

Hydrogeochemical characterization and statistical methods were used to investigate the groundwater quality and the origin of constituents (anthropic or natural) in groundwater of the Coreca area (Calabria, South Italy). Coreca is characterized by an articulated geological setting where the three main geological complexes that distinguish the Northern Calabria Peloritan Orogen (CPO) outcrop. This complex asset affects the quality of groundwater mainly exploited for irrigation use. In particular, the presence of ultramafic rocks (e.g., serpentinite and metabasite) promotes the release of harmful elements such as Cr and Ni. In the studied area, two groups of waters were identified: Ca-HCO3 waters strongly controlled by the interaction with Ca-rich phases (e.g., limestone), and Mg-HCO3 waters related to the interaction of meteoric water with the metamorphic units. Statistical elaboration allowed to detect, in the Mg-HCO3 group, a good correlation between Cr and Ni (not observed in Ca waters) and a negative correlation between Cr, Ca and Al, in agreement with direct interaction with ultramafic rocks characterized by low concentrations of CaO and Al2O3. The concentration of major and trace elements has been compared with the Italian law limit values and the drinking water guidelines provided by the World Health Organization (WHO). Only three samples showed Mn and Ni concentration higher than the Italian law threshold. Furthermore, the assessment of groundwater quality was carried out using salinity and metal indexes. The groundwater quality assessment for irrigation allowed to classify the resource as “excellent to good” and “good to permissible”; nevertheless, a salinity problem and a magnesium hazard were found. Lastly, a metal index (MI) calculation revealed values <1 for almost all samples, pointing to good overall quality. Only a few samples showed a value extremely higher than 1, attributable to prolonged interaction with ultramafic rocks and/or localized anthropogenic pollution. From a general point of view, groundwater showed a generally good quality except for limited areas (and limited to the set of constituents analyzed) and a mild exceedance of the maximum salinity thresholds that must be monitored over time. Through a multidisciplinary approach, it was possible to ascertain the main anomalies attributable to the interaction with the hosting rocks and not (with few exceptions) to anthropic processes.
The Influence of Eating at Home on Dietary Diversity and Airway Inflammation in Portuguese School-Aged Children
Authors: de Castro-Mendes Francisca , Cunha Pedro , Paciência Inês , Cavaleiro Rufo João , Farraia Mariana , Silva Diana , Padrão Patrícia , Delgado Luís , Moreira André , Moreira Pedro
Published: March 2021

Considering the negative impact of a lack of dietary diversity on children’s nutritional status, we aimed to describe dietary variety according to eating at home frequency and assessed its association with respiratory outcomes in school-aged children. This cross-sectional study included 590 children (49% girls) aged 7 to 12 years from 20 public schools located in city of Porto, Portugal. Daily frequency of eating at home groups were calculated and dietary diversity was calculated using a 10-food group score from a 24 h recall questionnaire. Spirometry and exhaled nitric oxide levels (eNO; <35 and ≥35 ppb) were assessed. The comparison of diet diversity according to the groups was performed by ANOVA and ANCOVA. The association between dietary diversity and respiratory outcomes was examined using regression models. In multivariate analysis, children in the highest group of eating at home episodes (≥4 occasions) obtained the lowest dietary diversity mean score, while the lowest group (<2) had the highest mean score (p-value 0.026). After adjustment for confounders, higher diet diversity (≥5 food groups) significantly decreased the odds of having an eNO ≥35. Diet diversity might decrease the chance of airway inflammation among children. However, having more eating episodes at home could be a barrier to a more diverse diet.
COVID-19 Seroprevalence among Healthcare Workers of a Large COVID-19 Hospital in Rome Reveals Strengths and Limits of Two Different Serological Tests
Authors: Vetrugno Giuseppe , La Milia Daniele Ignazio , D’Ambrosio Floriana , Di Pumpo Marcello , Pastorino Roberta , Boccia Stefania , Ricci Rosalba , De-Giorgio Fabio , Cicconi Michela , Foti Federica , Pascucci Domenico , Castrini Francesco , Carini Elettra , Cambieri Andrea , D’Alfonso Maria Elena , Capalbo Gennaro , Fantoni Massimo , Moscato Umberto , Staiti Domenico , De Simone Francesco Maria , Berloco Filippo , Damiani Gianfranco , Zega Maurizio , Cattani Paola , Posteraro Brunella , Sanguinetti Maurizio , Laurenti Patrizia
Published: March 2021

Healthcare workers are at the forefront against COVID-19, worldwide. Since Fondazione Policlinico Universitario A. Gemelli (FPG) IRCCS was enlisted as a COVID-19 hospital, the healthcare workers deployed to COVID-19 wards were separated from those with limited/no exposure, whereas the administrative staff were designated to work from home. Between 4 June and 3 July 2020, an investigation was conducted to evaluate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (IgG) antibodies among the employees of the FPG using point-of-care (POC) and venous blood tests. Sensitivity, specificity, and predictive values were determined with reverse-transcription polymerase chain reaction on nasal/oropharyngeal swabs as the diagnostic gold standard. The participants enrolled amounted to 4777. Seroprevalence was 3.66% using the POC test and 1.19% using the venous blood test, with a significant difference (p < 0.05). The POC test sensitivity and specificity were, respectively, 63.64% (95% confidence interval (CI): 62.20% to 65.04%) and 96.64% (95% CI: 96.05% to 97.13%), while those of the venous blood test were, respectively, 78.79% (95% CI: 77.58% to 79.94%) and 99.36% (95% CI: 99.07% to 99.55%). Among the low-risk populations, the POC test’s predictive values were 58.33% (positive) and 98.23% (negative), whereas those of the venous blood test were 92.86% (positive) and 98.53% (negative). According to our study, these serological tests cannot be a valid alternative to diagnose COVID-19 infection in progress.
More Than Just Assistive Devices: How a South African Social Enterprise Supports an Environment of Inclusion
Authors: Trafford Zara , van der Westhuizen Erna , McDonald Shona , Linegar Margi , Swartz Leslie
Published: March 2021

Appropriate assistive technology has the potential to considerably enhance quality of life, access to health and education, and social and economic participation for people with disabilities. Most disabled people in the world live in low- and middle-income countries where access to assistive devices and other support is severely lacking. There is little evidence that describes contextually relevant approaches to meeting these needs, particularly in African countries. We provide a detailed description of a South African organisation which has manufactured mobility and seating devices for children with disabilities since 1992. The Shonaquip Social Enterprise (SSE) also trains and builds capacity among a wide range of stakeholders (caregivers, health workers, educators, government, and communities) to acknowledge and advocate for the wellbeing of disabled children and adults, and works closely with government to strengthen existing service provisions. Using examples from the SSE, we highlight a number of useful principles to consider when trying to provide for the needs of people with disabilities, particularly in low-resource settings. While access to assistive devices is important, devices have limited capacity to improve participation if the broader environment is overly restrictive and stigmatising. Improved access to devices ought to be situated within a range of broader efforts to increase the inclusion and participation of people with disabilities.
The Personal and Interpersonal Components of Perfectionism: The Italian Validation of “Multidimensional Inventory of Perfectionism in Sport”
Authors: De Maria Alessandra , Mallia Luca , Lombardo Caterina , Vacca Mariacarolina , Zelli Arnaldo
Published: March 2021

The present research focused on the general theme of perfectionism in the sport domain, and it provided the first empirical validation of the original 72-item “Multidimensional Inventory of Perfectionism in Sport” (MIPS) among Italian athletes. The study, specifically, also focused on the relations linking personal and interpersonal components of perfectionism to athletes’ competitive anxiety. The research overall relied on data from 644 Italian sport science students and professional athletes and included both cross-sectional and longitudinal designs. Data analyses primarily focused on structural equation modeling, and the findings overall supported the psychometric and construct validity of the Italian version of the MIPS, also highlighting the key role of the personal components of perfectionism.
Physical Fitness in Young Padel Players: A Cross-Sectional Study
Authors: Courel-Ibáñez Javier , Llorca-Miralles Javier
Published: March 2021

This study aimed to examine the fitness characteristics and to identify the influence of gender and practice experience between young amateur padel players. A total of thirty-four padel players (n = 19 boys and 15 girls) aged 13 to 17 years old (age 14.6 ± 1.5 years; body mass 63.4 ± 14.5 kg; height 166.6 ± 9.8 cm; 6.2 ± 2.5 padel experience) volunteered to participate. Body composition was assessed by bioimpedance. Change of direction and agility were evaluated by two padel-adapted tests. Upper-limb strength measurement included overhead and side medicine ball throws with dominant and non-dominant hands. One-way ANCOVA was used to determine whether there were significant differences between gender and experience on fitness variables adjusting for age as a covariate. Male and female young padel players presented an apparently healthy body composition and exhibited similar performance in all fitness tests except for jumping ability. Practice experience seemed to influence upper-limb throwing strength, however, sub-analyses revealed no conclusive results. These results contribute to the existing knowledge in padel by providing new data about the fitness status of amateur young players aged 13 to 17 years old and open a window for future interventions using padel as a health promotion tool among youths.
Adaptation and Measurement Invariance by Gender of the Flourishing Scale in a Colombian Sample
Authors: Martín-Carbonell Marta , Espejo Begoña , Checa Irene , Fernández-Daza Martha
Published: March 2021

There is increasing interest in the study of flourishing as an indicator of subjective wellbeing. The objective herein was to adapt and study the psychometric properties of Diener’s Flourishing Scale (FS) among the Colombian population. Accordingly, a cross-sectional study was conducted with a non-probability sample of 1255 Colombian adults. The scale’s structure, invariance by gender, and convergent and concurrent validity were studied from a confirmatory perspective using structural equation models. The confirmatory factor analysis showed excellent fit indicators for the one-dimensional structure (CFI = 0.985, RMSEA = 0.039, SRMR = 0.020) as well as for the convergent (CFI = 0.909, RMSEA = 0.050, SRMR = 0.063) and concurrent (CFI = 0.966, RMSEA = 0.036, SRMR = 0.041) validity models. The correlations calculated among flourishing with positive and negative effects (PANAS), satisfaction with life (SWL), and optimism and pessimism (LOT) were statistically significant and as expected. Configural, metric, and scalar invariance across gender was confirmed. Percentiles were provided for the total score. The FS scale was a valid and reliable measure to assess high levels of wellbeing among the Colombian population.
Gratitude as a Protective Factor for Cyberbullying Victims: Conditional Effects on School and Life Satisfaction
Authors: Oriol Xavier , Varela Jorge , Miranda Rafael
Published: March 2021

Recently, studies linking the emotion of dispositional gratitude to cyberbullying have attracted attention. However, this is still a seminal research area that requires further scientific studies. Through longitudinal data, this study aims to analyze the mitigating effect of gratitude on cybervictimization and two indicators of adolescent subjective well-being, namely school and life satisfaction. To this end, 221 adolescents attending private schools in Peru (age: mean (M) = 12.09; standard deviation (SD) = 0.89) were selected to respond to a self-administered questionnaire in two waves that were six months apart. Descriptive data show that 27% of cybervictims also suffer other types of traditional bullying. The overlaps between forms of bullying contribute to higher probabilities of experiencing low school and life satisfaction compared to non-victims after six months. The results of the moderation analysis show that experience high gratitude help students to maintain stable levels of life satisfaction regardless of the prevalence of cyberbullying after six months The results are discussed in terms of the relevance of fostering gratitude from early ages.
Equivalent Weight: Connecting Exoskeleton Effectiveness with Ergonomic Risk during Manual Material Handling
Authors: Di Natali Christian , Chini Giorgia , Toxiri Stefano , Monica Luigi , Anastasi Sara , Draicchio Francesco , Caldwell Darwin , Ortiz Jesús
Published: March 2021

Occupational exoskeletons are becoming a concrete solution to mitigate work-related musculoskeletal disorders associated with manual material handling activities. The rationale behind this study is to search for common ground for exoskeleton evaluators to engage in dialogue with corporate Health & Safety professionals while integrating exoskeletons with their workers. This study suggests an innovative interpretation of the effect of a lower-back assistive exoskeleton and related performances that are built on the benefit delivered through reduced activation of the erector spinae musculature. We introduce the concept of “equivalent weight” as the weight perceived by the wearer, and use this to explore the apparent reduced effort needed when assisted by the exoskeleton. Therefore, thanks to this assistance, the muscles experience a lower load. The results of the experimental testing on 12 subjects suggest a beneficial effect for the back that corresponds to an apparent reduction of the lifted weight by a factor of 37.5% (the perceived weight of the handled objects is reduced by over a third). Finally, this analytical method introduces an innovative approach to quantify the ergonomic benefit introduced by the exoskeletons’ assistance. This aims to assess the ergonomic risk to support the adoption of exoskeletons in the workplace.
Predicting Survival in Veterans with Follicular Lymphoma Using Structured Electronic Health Record Information and Machine Learning
Authors: Li Chunyang , Patil Vikas , Rasmussen Kelli M. , Yong Christina , Chien Hsu-Chih , Morreall Debbie , Humpherys Jeffrey , Sauer Brian C. , Burningham Zachary , Halwani Ahmad S.
Published: March 2021

The most accurate prognostic approach for follicular lymphoma (FL), progression of disease at 24 months (POD24), requires two years’ observation after initiating first-line therapy (L1) to predict outcomes. We applied machine learning to structured electronic health record (EHR) data to predict individual survival at L1 initiation. We grouped 523 observations and 1933 variables from a nationwide cohort of FL patients diagnosed 2006–2014 in the Veterans Health Administration into traditionally used prognostic variables (“curated”), commonly measured labs (“labs”), and International Classification of Diseases diagnostic codes (“ICD”) sets. We compared performance of random survival forests (RSF) vs. traditional Cox model using four datasets: curated, curated + labs, curated + ICD, and curated + ICD + labs, also using Cox on curated + POD24. We evaluated variable importance and partial dependence plots with area under the receiver operating characteristic curve (AUC). RSF with curated + labs performed best, with mean AUC 0.73 (95% CI: 0.71–0.75). It approximated, but did not surpass, Cox with POD24 (mean AUC 0.74 [95% CI: 0.71–0.77]). RSF using EHR data achieved better performance than traditional prognostic variables, setting the foundation for the incorporation of our algorithm into the EHR. It also provides for possible future scenarios in which clinicians could be provided an EHR-based tool which approximates the predictive ability of the most accurate known indicator, using information available 24 months earlier.
The Impact of Cultural Immersion Experience on Identity Transformation Process
Authors: Onosu Gloria
Published: March 2021

This study focused on understanding the cultural immersion experience of students who participated in Study Abroad Programs (SAP) and Global Service Learning Programs (GSL). The study looked at how the immersion experience impacted the participants’ view of self and others upon re-entry into their local community. Specifically, we applied the perspective transformation theoretical framework to analyze the extent to which participation in cultural immersion programs transforms students’ perceptions of self and others. The analysis of the semi-structured interviews suggested that by engaging in intentional immersion and guided reflections, participants became aware of the need to reevaluate their perspectives, expectations, and assumptions about self and others. We also found that there were differences in the way participants experienced the cultural immersion process and the impact it had on cultural awareness and self-identity.
Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review
Authors: Badenes Rafael , Qeva Ega , Giordano Giovanni , Romero-García Nekane , Bilotta Federico
Published: March 2021

Delayed neurocognitive recovery and postoperative neurocognitive disorders are major complications of surgery, hospitalization, and anesthesia that are receiving increasing attention. Their incidence is reported to be 10–80% after cardiac surgery and 10–26% after non-cardiac surgery. Some of the risk factors include advanced age, level of education, history of diabetes mellitus, malnutrition, perioperative hyperglycemia, depth of anesthesia, blood pressure fluctuation during surgery, chronic respiratory diseases, etc. Scientific evidence suggests a causal association between anesthesia and delayed neurocognitive recovery or postoperative neurocognitive disorders, and various pathophysiological mechanisms have been proposed: mitochondrial dysfunction, neuroinflammation, increase in tau protein phosphorylation, accumulation of amyloid-β protein, etc. Insulin receptors in the central nervous system have a non-metabolic role and act through a neuromodulator-like action, while an interaction between anesthetics and central nervous system insulin receptors might contribute to anesthesia-induced delayed neurocognitive recovery or postoperative neurocognitive disorders. Acute or chronic intranasal insulin administration, which has no influence on the blood glucose concentration, appears to improve working memory, verbal fluency, attention, recognition of objects, etc., in animal models, cognitively healthy humans, and memory-impaired patients by restoring the insulin receptor signaling pathway, attenuating anesthesia-induced tau protein hyperphosphorylation, etc. The aim of this review is to report preclinical and clinical evidence of the implication of intranasal insulin for preventing changes in the brain molecular pattern and/or neurobehavioral impairment, which influence anesthesia-induced delayed neurocognitive recovery or postoperative neurocognitive disorders.
Sustained Effects of High-Intensity Interval Exercise and Moderate-Intensity Continuous Exercise on Inhibitory Control
Authors: Tian Shudong , Mou Hong , Qiu Fanghui
Published: March 2021

This study examined the immediate and sustained effects of high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) bouts on inhibitory control in young adults. Participants (n = 41) engaged in (1) a session of HIIE, involving 10 one-minute runs on a treadmill at an intensity targeting 85–90% HRmax interspersed with self-paced walking at 60% HRmax; (2) a session of MICE, involving a 20 min run on a treadmill at an intensity of 60–70% HRmax; and (3) a control session, involving 24 min of resting on separate days in a counterbalanced order. Using a flanker task, inhibitory control was assessed before the intervention (t0), immediately after the session (t1), and then at 30 min (t2), 60 min (t3), and 90 min (t4) after the session. During the flanker task, the response time (RT) for incongruent trials immediately after HIIE was significantly shortened compared to that before exercise. This shortened RT was sustained for 90 min post-exercise during recovery from HIIE. Interference scores of RT were also reduced after HIIE, benefitting inhibitory control, and were maintained for 90 min post-exercise. Reduced accuracy interference scores were recorded following HIIE compared to the control session. Improvements in inhibitory control elicited by HIIE were sustained for at least 90 min post-exercise. In contrast, an improvement in inhibitory control was not observed during the MICE session. HIIE might represent a time-efficient approach for enhancing inhibitory control.
Development of Modern Racism Scale in Global Airlines: A Study of Asian Female Flight Attendants
Authors: Yu Myoungjin , Hyun Sunghyup Sean
Published: March 2021

Due to the globalization of the airline industry, global airlines are focusing human resource management on diversity strategies and employing flight attendants of various races. Multinational flight attendants have brought many positive results; conversely, discrimination has led to negative phenomena such as racism. Nevertheless, research focusing on global airline racism in tourism studies is unprecedented. Therefore, the purpose of this study is to develop a modern racism scale rating the discrimination perceived by Asian female flight attendants on global airlines. It was developed following Churchill’s eight steps (1979). This study derived measurement items through a literature review, in-depth interviews, first and second expert surveys, and a preliminary survey. These items were developed on a scale through a validity and reliability assessment and were finally confirmed as six dimensions and 24 measurement items. Lastly, research implications were discussed.
Postural Responses to Sudden Horizontal Perturbations in Tai Chi Practitioners
Authors: Sever Jernej , Babič Jan , Kozinc Žiga , Šarabon Nejc
Published: March 2021

Tai Chi has been shown to elicit numerous positive effects on health and well-being. In this study, we examined reactive postural control after sudden unloading horizontal perturbations, which resembled situations encountered during Tai Chi. The study involved 20 participants, 10 in the Tai Chi group (age: 37.4 ± 7.8 years), who had been regularly training the push-hand technique for at least 7 years, and 10 in the control group, consisting of healthy adults (age: 28.8 ± 5.0). Perturbations were applied at three different positions (hips, shoulders, and arms) via the load-release paradigm. Twenty measurements were carried out for each perturbation position. We measured peak vertical and horizontal forces on the ground (expressed percentage of body mass (%BM)), peak center of pressure displacement and peak horizontal and vertical velocities at the knee, hip and shoulder joints. The Tai Chi group exhibited smaller increases in vertical ground reaction forces when perturbations were applied at the hips (11.5 ± 2.1 vs. 19.6 ± 5.5 %BW; p = 0.002) and the arms (14.1 ± 4.2 vs. 23.2 ± 8.4 %BW; p = 0.005). They also responded with higher horizontal force increase after hip perturbation (16.2 ± 3.2 vs. 13.1 ± 2.5 %BW; p < 0.001). Similar findings were found when observing various outcomes related to velocities of vertical movement. The Tai Chi group also showed lower speeds of backward movement of the knee (p = 0.005–0.009) after hip (0.49 ± 0.13 vs. 0.85 ± 0.14 m/s; p = 0.005) and arm perturbations (0.97 ± 0.18 vs. 1.71 ± 0.29 m/s; p = 0.005). Center of pressure displacements were similar between groups. Our study demonstrated that engaging in Tai Chi could be beneficial to reactive postural responses after sudden perturbations in a horizontal direction; however, future interventional studies are needed to directly confirm this. Moreover, because of the age difference between the groups, some confounding effects of age cannot be ruled out.
Effects of a Comprehensive Pulmonary Rehabilitation in Severe Post-COVID-19 Patients
Authors: Spielmanns Marc , Pekacka-Egli Anna-Maria , Schoendorf Sabine , Windisch Wolfram , Hermann Matthias
Published: March 2021

Background: Severe COVID-19 infection often leads to impairments requiring pulmonary rehabilitation (PR) following the acute phase. Little is known about the efficacy of PR in these patients. We therefore compared post-COVID-19 patients (PG) referred to PR patients with other lung diseases (LG). Methods: 99 PG were admitted to PR. In a prospective design, the results of PG were collected and compared to the results of LG of 2019 (n = 419) according to Functional Independence Measurement (FIM), Cumulative Illness Rating Scale (CIRS), 6-min walk test (6-MWT), duration of PR, and Feeling Thermometer (FT). Results: According to age, sex, and CIRS, both groups showed no significant differences. The improvements in the 6-MWT in the pre to post comparison were on average 180 (±101) meters for PG and 102 (±89) meters for LG (p < 0.001). FT showed a significant enhancement for PG of 21 (±14) points and for LG of 17 (±16) points (p < 0.039), while FIM significantly increased by 11 (±10) points in PG and 7 (±8) points in LG (p < 0.001). Conclusions: Comprehensive PR in PG is very effective according to the results in FIM, 6-MWT and FT. Therefore, we recommend PR following severe post-COVID-19 infections.
Obesity and Chosen Non-Communicable Diseases in PURE Poland Cohort Study
Authors: Zatońska Katarzyna , Psikus Piotr , Basiak-Rasała Alicja , Stępnicka Zuzanna , Gaweł-Dąbrowska Dagmara , Wołyniec Maria , Gibka Julia , Szuba Andrzej , Połtyn-Zaradna Katarzyna
Published: March 2021

Introduction: Obesity has been associated with a higher risk of morbidity, disability, and death. The objective of this study was to assess the prevalence of obesity and chosen non-communicable diseases (NCDs) in the PURE Poland cohort study. Material and Methods: The study covers a group of 2035 people (1281 women and 754 men), who live in urban and rural areas of Lower Silesian voivodeship. The baseline study was conducted between 2007–2010. The data on demographic status and history of diseases were collected using questionnaires. The anthropometric parameters, blood pressure, blood lipids, and glucose level were measured. Results: Normal body weight was observed in 28.1% of participants, whereas overweight and obesity were observed in 40.1% and 31.1% of participants, respectively. Moreover, there was a significant difference in the body weight between genders. Prevalence of obesity was similar in men and women (31.0% and 31.1%, respectively). Obesity was more prevalent in rural vs. urban residents (38.5% and 26.0%, respectively). In a logistic regression analysis, the odds for obesity was two-fold higher in participants aged >64 years and rural inhabitants (OR 1.91; 95% CI 1.36–2.70; OR 1.79; 95% CI 1.48–2.16, respectively). Participants with obesity had 2.5-fold higher odds for diabetes and hypertension and two-fold higher odds for CHD in comparison with non-obese individuals (OR 2.74; 95% CI 2.01–3.73, OR 2.54; 95% CI 2.03–3.17, OR 1.88; 95% CI 1.26–2.80, respectively). Conclusions: Taken together, the prevalence of obesity was associated with particular socio-demographic factors (age, place of residence, and level of education) as well as diabetes, hypertension, and coronary heart disease.
Quality of Life Prior and in the Course of the COVID-19 Pandemic: A Nationwide Cross-Sectional Study with Brazilian Dietitians
Authors: da Costa Matos Raquel Adjafre , Akutsu Rita de Cassia Coelho de Almeida , Zandonadi Renata Puppin , Botelho Raquel Braz Assunção
Published: March 2021

Dietitians as healthcare professionals could decrease their quality of life during the SARS-COV-2 pandemic period; therefore, this study aimed to compare Brazilian dietitians’ perceptions of quality of life before and during the pandemic. This nationwide cross-sectional research aimed to evaluate Brazilian dietitians’ quality of life before and in the course of the COVID-19 pandemic, using a previously validated self-administered instrument WHO-QOL-BREF in Brazilian-Portuguese. The questionnaire was composed of 26 items (four domains) to evaluate life quality (physical, psychological, social relationship, and environment). The questionnaire also presented some sociodemographic variables and three questions about the COVID-19 pandemic. It was applied using GoogleForms® platform (Google LLC, Mountain View, CA, USA). For the statistical analysis of data, Paired T-test, Chi-squared test, and Analysis of Variance were used. A total of 1290 Brazilian dietitians replied to the instrument. Comparing quality of life (QoL) before SARS-COV-2 (3.83 ± 0.59) and during the pandemic (3.36 ± 0.66), data was statistically different. Comparing prior and in the course of the COVID-19 pandemic, all variables and domains presented statistical differences (better before the pandemic period). Among Brazilian dietitians, the psychological health domain was the most affected. The Sars-Cov-2 pandemic negatively impacted the QoL of Brazilian dietitians since health professionals face changes in their lives because of work.
Association between Exposure to Alcohol’s Harm to Others and Health-Related Quality of Life in Korean Adults: A Nationwide Population-Based Study
Authors: Eum Mi-Jung , Choi Min-Jung
Published: March 2021

This study aimed to investigate the association between exposure to alcohol’s harm to others (AHTO) and health-related quality of life HRQoL using a nationally representative sample. Data from 2016–2018 of 17,346 South Korean individuals aged ≥19 years were obtained from the Korea National Health and Nutrition Examination Survey. HRQoL was evaluated using the European Quality of Life–5 Dimensions (EQ-5D) index. A significant positive association was found between exposure to AHTO and lower EQ-5D scores (p = 0.022). In the final model of multiple regression analysis, participants’ HRQoL decreased by 0.932 points when exposed to AHTO (R2 = 36.5%, p < 0.001). In addition, the exposure to AHTO group had significantly higher odds ratios (OR) for pain/discomfort (OR: 1.42, 95% CI: 1.15–1.75) and anxiety/depression (OR: 1.55, 95% CI: 1.68–2.80) compared to the non-AHTO group. Further studies are required for intervention when exposed to reduce the pain/discomfort and anxiety/depression in AHTO victims as well as to reduce the incidence of AHTO.
The Economic Burden of Dementia: Evidence from a Survey of Households of People with Dementia and Their Caregivers
Authors: Oba Hikaru , Kadoya Yoshihiko , Okamoto Haruka , Matsuoka Teruyuki , Abe Yoshinari , Shibata Keisuke , Narumoto Jin
Published: March 2021

Although a cognitive impairment such as dementia causes serious economic problems among older people, its impact on economic activities is unclear. This study investigated the actual conditions of economic activities and the current status of the financial support systems among people with dementia and caregivers. One hundred and five dyads participated in the survey. Each dyad consisted of an older person with Alzheimer’s disease and their caregiver. The Mini-Mental State Examination (MMSE) and Functional Assessment Staging (FAST) were used to evaluate the cognitive functions of people with dementia. The caregivers were asked questions concerning the financial status of the household and their utilization of the financial support systems available to people with dementia. Average monthly care costs significantly increased according to the severity of dementia, while household income and spending incurred no significant changes. People with dementia experienced financial problems (including a large amount of erroneously purchased, unnecessary shopping), even though their assets were informally managed by their caregivers. Financial support systems such as adult guardianship and civil trust systems were rarely known and used. We proposed the propagation of the adult guardianship and civil trust systems and the development of contract guidelines for elderly customers including people with dementia.
Physical and Sedentary Activities in Association with Reproductive Outcomes among Couples Seeking Infertility Treatment: A Prospective Cohort Study
Authors: Läänelaid Siret , Ortega Francisco B. , Kunovac Kallak Theodora , Joelsson Lana , Ruiz Jonatan R. , Hreinsson Julius , Wånggren Kjell , Stavreus-Evers Anneli , Kalda Ruth , Salumets Andres , Altmäe Signe
Published: March 2021

Background: The aim of this study was to investigate the association of physical activity (PA) with assisted reproductive technology (ART) treatment and pregnancy outcomes among couples seeking infertility treatment. Methods: This prospective cohort study was carried out among 128 infertile individuals (64 couples), entering the infertility clinic for ART procedures. Baseline PA (before entering any treatment) was assessed using accelerometry for both women and men. For every couple the infertility treatment outcomes were recorded. Results: The couples that required invasive ART procedures such as in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) spent less time in vigorous PA (−73 min/week per couple, woman + man) than those couples who became spontaneously pregnant after entering the study (p = 0.001). We observed no significant associations between the time spent in physical activities and positive pregnancy test or live birth. Conclusions: Our results do not support a positive nor negative relation between the time the couples spent in physical activities and the chances of getting pregnant or having a baby among patients seeking infertility treatment. However, couples undergoing invasive ART procedures did less vigorous PA than couples that became spontaneously pregnant, suggesting that PA may interfere with their reproductive health.
Short Communication: Integrase Strand Transfer Inhibitors Drug Resistance Mutations in Puerto Rico HIV-Positive Individuals
Authors: López Pablo , Tirado Grissell , Arias Andrea , Sánchez Raphael , Rodríguez-López Elliott R. , Rivera-Amill Vanessa
Published: March 2021

The HIV-1 integrase viral protein is responsible for incorporating the viral DNA into the genomic DNA. The inhibition of viral integration into host cell DNA is part of recent therapeutic procedures. Combination therapy with protease and reverse transcriptase inhibitors has demonstrated good synergistic results in reducing viral replication. The purpose of this study is to assess the occurrence of integrase drug resistance mutations from the period comprising 2013 through 2018 in Puerto Rico (PR). We analyzed 131 nucleotide sequences available in our HIV genotyping database, and we performed drug resistance mutation analyses using the Stanford HIV Drug Resistance Database. Twenty-one sequences (16.03%) harbored major or resistance-associated mutations. We identified the Q148HKR, G140S, Y143R, N155H, S147G, and E138EA major drug resistance mutations and the D232DN, T97TA, E157Q, G163GART accessory mutations. We detected high-level drug resistance to Elvitegravir and Raltegravir (76.19% and 85.71%). Moreover, we identified sequences harboring drug resistance mutations that could provide resistance to Dolutegravir. The transmission of strains with integrase antiretroviral resistance has been previously documented in treatment naïve patients. Given the increase of patients treated with integrase inhibitors, surveillance of drug resistance mutations is an essential aspect of PR’s clinical management of HIV infection.
Hospital Climate and Peer Report Intention on Adverse Medical Events: Role of Attribution and Rewards
Authors: Li Xiaoxiang , Zhang Shuhan , Chen Rong , Gu Dongxiao
Published: March 2021

Adverse medical events (AMEs) often occur in the healthcare workplace, and studies have shown that a positive atmosphere can reduce their incidence by increasing peer report intention. However, few studies have investigated the effect and action mechanism therein. We aimed to extend upon these studies by probing into the relationship between hospital climate and peer report intention, along with the mediating effect of attribution tendency and moderating effects of rewards. For this purpose, a cross-sectional survey was administered in a hospital among health professionals. We collected 503 valid questionnaires from health professionals in China and verified the hypothesis after sorting the questionnaires. The results of empirical analysis show that a positive hospital climate significantly induces individual internal attribution tendency, which in turn exerts a positive effect on peer report intention. Contract reward also helps to increase peer report intention, especially for health professionals with an internal attribution tendency. The findings contribute to the literature regarding AME management in hospitals by providing empirical evidence of the necessity for hospital climate and contract reward, and by providing insights to improve their integrated application.
Effects of a 48-Day Home Quarantine during the Covid-19 Pandemic on the First Outdoor Running Session among Recreational Runners in Spain
Authors: Mosqueira-Ourens Manuel , Sánchez-Sáez José M. , Pérez-Morcillo Aitor , Ramos-Petersen Laura , López-Del-Amo Andrés , Tuimil José L. , Varela-Sanz Adrián
Published: March 2021

COVID-19-induced quarantine may lead to deleterious effects on health status as well as to impaired performance and increased injury risk when re-starting training after lockdown. We investigated the physical activity (PA) habits of recreational runners in Spain during a 48-day home quarantine during the COVID-19 pandemic and the characteristics of the first outdoor running session after confinement. A cross-sectional study, including a self-reported running questionnaire completed after the first outdoor running session after quarantine, was performed. Three hundred recreational runners (74% males; 60% 18–40 years old; most typical running experience >3 years, 10–30 km weekly running distance distributed in 3–4 sessions) were considered for analysis. Advanced runners ran, at least, 4 days/week and participated in running events. They performed significantly longer and more non-supervised weekly training sessions during confinement (p < 0.01 for both) than novice and amateur runners. Most runners performed their first outdoor running session on asphalt (65.3%) and ran 5 to 10 km (61%) at a pace above 5 min/km (60%), reporting no pain before (77%), during (64%), and 24 h after (76%) the session. Advanced runners performed a significantly longer running session, at a higher pace, and covered a greater distance (p < 0.01 for all) than novice and amateur runners, while enjoyment and motivation tended to be significantly higher when runners’ level increased (p < 0.05). Higher training levels prior to and during confinement may lower the collateral effects (e.g., detraining, injury risk) of home quarantine when runners return to previous PA levels.
The Challenges of Hospitals’ Planning & Control Systems: The Path toward Public Value Management
Authors: Nuti Sabina , Noto Guido , Grillo Ruggieri Tommaso , Vainieri Milena
Published: March 2021

In the last decades, public management has been subjected to a shift from the New Public Management (NPM) paradigm to the Public Value Management (PVM) one. Thus, management practices such as Planning and Control (P&C) systems have been called to evolve accordingly. The health care sector has not escaped this process. This paper focuses on the evolution of hospitals’ P&C systems to support the paradigm shift from the NPM paradigm to the PVM one. In particular, the paper aims at exploring whether hospitals’ P&C systems in Italy evolved, or are evolving, consistently with PVM and what are the expected benefits related to such a paradigm switch. To address the research aim, the paper is based on a review of scientific and grey literature and the case study of the diabetic-foot pathway in an Italian Regional Healthcare System. The results of this study show that the current P&C systems in Italian hospitals are not yet designed to support the shift toward the PVM approach and are still mainly focused on financial aspects and intra-organizational dynamics. Combining traditional P&Cs with performance measures assessing the system’s outcomes may support hospitals in aligning their goals with the health system they are operating within and, therefore, P&C systems may represent an important driving force toward change. Such results provide suggestions for both practitioners and academics on how to adapt P&C systems to better support the implementation of current strategies of the public sector.
Dark Tourism in Southern Spain (Córdoba): An Analysis of the Demand
Authors: Millán María Genoveva Dancausa , Millán Vázquez de la Torre María Genoveva , Hernández Rojas Ricardo
Published: March 2021

In recent decades, there has been a change in tourists’ tastes; they want to experience something novel. To satisfy this demand, a new type of tourism, known as “dark tourism”, has arisen; it has various modalities, among which cemetery tourism and ghost tourism stand out, in addition to very different motivations from those of the cultural tourist. In this type of tourism, cemeteries are not visited to appreciate their architecture or heritage but to explore a morbid curiosity about the people buried there; ghost tourism or paranormal tourism seizes on the desire to know the events that occurred there and tends to have macabre content. This study analyzes dark tourism in the province of Córdoba in southern Spain with the aim of knowing the profile of the tourist and his motivation. This study additionally will forecast the demand for this type of tourism, using autoregressive integrated moving average (ARIMA) models, which allow us to know this market’s evolution and whether any promotional action should be carried out to promote it.
Polycyclic Aromatic Hydrocarbons in Indoor Dust Collected during the COVID-19 Pandemic Lockdown in Saudi Arabia: Status, Sources and Human Health Risks
Authors: Alamri Sultan Hassan , Ali Nadeem , Ali Albar Hussain Mohammed Salem , Rashid Muhammad Imtiaz , Rajeh Nisreen , Ali Qutub Majdy Mohammed , Malarvannan Govindan
Published: March 2021

To control the spread of coronavirus disease (COVID-19), Saudi Arabia’s government imposed a strict lockdown during March–July 2020. As a result, the public was confined to indoors, and most of their daily activities were happening in their indoor places, which might have resulted in lower indoor environment quality. Polycyclic aromatic hydrocarbons (PAHs) were analyzed in household dust (n = 40) collected from different residential districts of Jeddah, Saudi Arabia, during the lockdown period. PAHs’ levels were two folds higher than the previously reported PAHs in indoor dust from this region. We detected low molecular weight (LMW) with two to four aromatic ring PAHs in all the samples with a significant contribution from Phenanthrene (Phe), present at an average concentration of 1590 ng/g of dust. Although high molecular weight (HMW) (5–6 aromatic ring) PAHs were detected at lower concentrations than LMW PAHs, however, they contributed >90% in the carcinogenic index of PAHs. The estimated daily intake (EDI) of specific PAHs was above the reference dose (RfD) for young children in high-end exposure and the calculated Incremental Lifetime Cancer Risk (ILCR) was >1.00 × 10−4 for both Saudi adults and young children. The study highlighted that indoor pollution has increased significantly during lockdown due to the increased indoor activities and inversely affect human health. This study also warrants to conduct more studies involving different chemicals to understand the indoor environment quality during strict lockdown conditions.