bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Chitosan, Salicylic Acid and Jasmonic Acid on Phenylpropanoid Accumulation in Germinated Buckwheat (Fagopyrum esculentum Moench)
Authors: Park Chang Ha , Yeo Hyeon Ji , Park Ye Eun , Chun Se Won , Chung Yong Suk , Lee Sook Young , Park Sang Un
Published: May 2019

The present study investigated the effects of jasmonic acid (JA), chitosan, and salicylic acid (SA) on the accumulation of phenolic compounds in germinated buckwheat. A total of six phenolics were detected in the buckwheat treated with different concentrations of SA (50, 100, and 150 mg/L), JA (50, 100, and 150 μM), and chitosan (0.01, 0.1, and 0.5%) using high-performance liquid chromatography (HPLC). The treatment with 0.1% chitosan resulted in an accumulation of the highest levels of phenolic compounds as compared with the control and the 0.01 and 0.5% chitosan treatments. The treatment with 150 μM JA enhanced the levels of phenolics in buckwheat sprouts as compared with those observed in the control and the 50 and 100 μM JA-treated sprouts. However, the SA treatment did not affect the production of phenolic compounds. After optimizing the treatment concentrations of elicitors (chitosan and JA), a time-course analysis of the phenolic compounds detected in the germinated buckwheat treated with 0.1% chitosan and 150 μM JA was performed. Buckwheat treated with 0.1% chitosan for 72 h showed higher levels of phenolic compounds than all control samples. Similarly, the germinated buckwheat treated with JA for 48 and 72 h produced higher amounts of phenolic compounds than all control samples. This study elucidates the influence of SA, JA, and chitosan on the production of phenolic compounds and suggests that the treatment with optimal concentrations of chitosan and JA for an optimal time period improved the production of phenolic compounds in germinated buckwheat.
Diversification of Transposable Elements in Arthropods and Its Impact on Genome Evolution
Authors: Wu Changcheng , Lu Jian
Published: May 2019

Transposable elements (TEs) are ubiquitous in arthropods. However, analyses of large-scale and long-term coevolution between TEs and host genomes remain scarce in arthropods. Here, we choose 14 representative Arthropoda species from eight orders spanning more than 500 million years of evolution. By developing an unbiased TE annotation pipeline, we obtained 87 to 2266 TE reference sequences in a species, which is a considerable improvement compared to the reference TEs previously annotated in Repbase. We find that TE loads are diversified among species and were previously underestimated. The highly species- and time-specific expansions and contractions, and intraspecific sequence diversification are the leading driver of long terminal repeat (LTR) dynamics in Lepidoptera. Terminal inverted repeats (TIRs) proliferated substantially in five species with large genomes. A phylogenetic comparison reveals that the loads of multiple TE subfamilies are positively correlated with genome sizes. We also identified a few horizontally transferred TE candidates across nine species. In addition, we set up the Arthropod Transposable Elements database (ArTEdb) to provide TE references and annotations. Collectively, our results provide high-quality TE references and uncover that TE loads and expansion histories vary greatly among arthropods, which implies that TEs are an important driving force shaping the evolution of genomes through gain and loss.
Genome-Wide Signatures of Selection Detection in Three South China Indigenous Pigs
Authors: Diao Shuqi , Huang Shuwen , Chen Zitao , Teng Jinyan , Ma Yunlong , Yuan Xiaolong , Chen Zanmou , Zhang Hao , Li Jiaqi , Zhang Zhe
Published: May 2019

South China indigenous pigs are famous for their superior meat quality and crude feed tolerance. Saba and Baoshan pigs without saddleback were located in the high-altitude area of Yunnan Province, while Tunchang and Ding’an pigs with saddleback were located in the low-altitude area of Hainan Province. Although these pigs are different in appearance, the underlying genetic differences have not been investigated. In this study, based on the single-nucleotide polymorphism (SNP) genotypes of 124 samples, both the cross-population extended haplotype homozygosity (XP-EHH) and the fixation index (FST) statistic were used to identify potential signatures of selection in these pig breeds. We found nine potential signatures of selection detected simultaneously by two methods, annotated 22 genes in Hainan pigs, when Baoshan pigs were used as the reference group. In addition, eleven potential signatures of selection detected simultaneously by two methods, annotated 24 genes in Hainan pigs compared with Saba pigs. These candidate genes were most enriched in GO: 0048015~phosphatidylinositol-mediated signaling and ssc00604: Glycosphingolipid biosynthesis—ganglio series. These selection signatures were likely to overlap with quantitative trait loci associated with meat quality traits. Furthermore, one potential selection signature, which was associated with different coat color, was detected in Hainan pigs. These results contribute to a better understanding of the underlying genetic architecture of South China indigenous pigs.
Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan
Authors: Liaw Yi-Ching , Liaw Yung-Po , Lan Tsuo-Hung
Published: May 2019

The fat mass and obesity-associated (FTO) gene is a significant genetic contributor to polygenic obesity. We investigated whether physical activity (PA) modulates the effect of FTO rs3751812 on body mass index (BMI) among Taiwanese adults. Analytic samples included 10,853 Taiwan biobank participants. Association of the single-nucleotide polymorphism (SNP) with BMI was assessed using linear regression models. Physical activity was defined as any kind of exercise lasting 30 min each session, at least three times a week. Participants with heterozygous (TG) and homozygous (TT) genotypes had higher BMI compared to those with wild-type (GG) genotypes. The β value was 0.381(p < 0.0001) for TG individuals and 0.684 (p = 0.0204) for TT individuals. There was a significant dose-response effect among carriers of different risk alleles (p trend <0.0001). Active individuals had lower BMI than their inactive counterparts (β = −0.389, p < 0.0001). Among the active individuals, significant associations were found only with the TG genotype (β = 0.360, p = 0.0032). Inactive individuals with TG and TT genotypes had increased levels of BMI compared to those with GG genotypes: Their β values were 0.381 (p = 0.0021) and 0.950 (p = 0.0188), respectively. There was an interaction between the three genotypes, physical inactivity, and BMI (p trend  = 0.0002). Our data indicated that increased BMI owing to genetic susceptibility by FTO rs3751812 may be reduced by physical activity.
Identification of Histone H3 (HH3) Genes in Gossypium hirsutum Revealed Diverse Expression During Ovule Development and Stress Responses
Authors: Qanmber Ghulam , Ali Faiza , Lu Lili , Mo Huijuan , Ma Shuya , Wang Zhi , Yang Zuoren
Published: May 2019

Histone acts as the core for nucleosomes and is a key protein component of chromatin. Among different histone variants, histone H3 (HH3) variants have been reported to play vital roles in plant development. However, biological information and evolutionary relationships of HH3 genes in cotton remain to be elucidated. The current study identified 34 HH3 genes in Gossypium hirsutum. Phylogenetic analysis classified HH3 genes of 19 plant species into eight distinct clades. Sequence logos analysis among Arabidopsis, rice, and G. hirsutum amino acid residues showed higher conservation in amino acids. Using collinearity analysis, we identified 81 orthologous/paralogous gene pairs among the four genomes (A, D, At, and Dt) of cotton. Further, orthologous/paralogous and the Ka/Ks ratio demonstrated that cotton HH3 genes experienced strong purifying selection pressure with restricted functional divergence resulting from segmental and whole genome duplication. Expression pattern analysis indicated that GhHH3 genes were preferentially expressed in cotton ovule tissues. Additionally, GhHH3 gene expression can be regulated by abiotic stresses (cold, heat, sodium chloride (NaCl), and polyethylene glycol (PEG)) and phytohormonal (brassinolide (BL), gibberellic acid (GA), indole-3-acetic acid (IAA), salicylic acid (SA), and methyl jasmonate (MeJA)) treatments, suggesting that GhHH3 genes might play roles in abiotic and hormone stress resistance. Taken together, this work provides important information to decipher complete molecular and physiological functions of HH3 genes in cotton.
Exploring Food Access and Sociodemographic Correlates of Food Consumption and Food Insecurity in Zanzibari Households
Authors: Nyangasa Maria Adam , Buck Christoph , Kelm Soerge , Sheikh Mohammed , Hebestreit Antje
Published: May 2019

Rapid growth of the Zanzibari population and urbanization are expected to impact food insecurity and malnutrition in Zanzibar. This study explored the relationship between food access (FA) and sociodemographic correlates with food consumption score and food insecurity experience scale. Based on cross-sectional data of 196 randomly selected households, we first investigated the association between sociodemographic correlates and Food Consumption Score (FCS) and Food Insecurity Experience Scale using multilevel Poisson regression. Secondly, the role of FA in these associations was investigated by interaction with the respective correlates. About 65% of households had poor food consumption, and 32% were severely food-insecure. Poor FA was more prevalent in households with poor food consumption (71%). Polygamous households and larger households had a higher chance for severe food insecurity. In the interaction with FA, only larger households with poor FA showed a higher chance for severe food insecurity. In households having no vehicle, good FA increased the chance of having acceptable FCS compared to poor FA. By contrast, urban households with good FA had a twofold chance of acceptable FCS compared to rural household with poor FA. Poor FA, poor food consumption and food insecurity are challenging; hence, facilitating households’ FA may improve the population’s nutrition situation.
Moving to an “Active” Biophilic Designed Office Workplace: A Pilot Study about the Effects on Sitting Time and Sitting Habits of Office-Based Workers
Authors: Wallmann-Sperlich Birgit , Hoffmann Sophie , Salditt Anne , Bipp Tanja , Froboese Ingo
Published: May 2019

Promising initial insights show that offices designed to permit physical activity (PA) may reduce workplace sitting time. Biophilic approaches are intended to introduce natural surroundings into the workplace, and preliminary data show positive effects on stress reduction and elevated productivity within the workplace. The primary aim of this pilot study was to analyze changes in workplace sitting time and self-reported habit strength concerning uninterrupted sitting and PA during work, when relocating from a traditional office setting to “active” biophilic-designed surroundings. The secondary aim was to assess possible changes in work-associated factors such as satisfaction with the office environment, work engagement, and work performance, among office staff. In a pre-post designed field study, we collected data through an online survey on health behavior at work. Twelve participants completed the survey before (one-month pre-relocation, T1) and twice after the office relocation (three months (T2) and seven months post-relocation (T3)). Standing time per day during office hours increased from T1 to T3 by about 40 min per day (p < 0.01). Other outcomes remained unaltered. The results suggest that changing office surroundings to an active-permissive biophilic design increased standing time during working hours. Future larger-scale controlled studies are warranted to investigate the influence of office design on sitting time and work-associated factors during working hours in depth.
Perspective of Pakistani Physicians towards Hospital Antimicrobial Stewardship Programs: A Multisite Exploratory Qualitative Study
Authors: Hayat Khezar , Rosenthal Meagen , Gillani Ali Hassan , Zhai Panpan , Aziz Muhammad Majid , Ji Wenjing , Chang Jie , Hu Hao , Fang Yu
Published: May 2019

Background: Antimicrobial resistance (AMR) is a global threat and the antimicrobial stewardship program (ASP) is a globally used tool to combat AMR. There is little information on the views among Pakistani physicians regarding AMR and the benefits of hospital antimicrobial stewardship implementation. This study was designed to explore the physicians’ views about ASP. Methods: Qualitative face-to-face and telephonic interviews were conducted by using purposive sampling method with 22 physicians working in seven tertiary care public hospitals of Punjab, Pakistan. All interviews were audio recorded and transcribed verbatim. Qualitative software was used, and a thematic analysis was conducted. Results: Three broad themes were identified: (1) the growing concern of antimicrobial resistance in Pakistan, (2) the role(s) of healthcare professionals in antibiotic prescribing, and (3) managing antibiotic resistance in hospitals. Inadequate resources, poor healthcare facilities, and insufficiently trained medical staff were the major hurdles in ASP implementation in Pakistan. Conclusions: Our study found a poor familiarity of hospital ASP among physicians working in public sector tertiary care teaching hospitals, and a number of distinct themes emerged during this study that could be helpful in establishing the concept of hospital ASP in Pakistan. Overall, physicians showed a positive attitude towards the enforcement of ASP in all healthcare settings, including teaching hospitals.
Influence of Risk of Drug–Drug Interactions and Time Availability on Patient Trust, Satisfaction, and Cooperation with Clinical Pharmacists
Authors: Chou Ying-Chyi , Dang Van Thac , Yen Hsin-Yi , Lai Kuan-Ming
Published: May 2019

Patients with multiple diseases requiring several medications often face the risk of drug–drug interactions (DDIs). Such patients need more care and services from clinical pharmacists. Given the importance of this issue in clinical medicine, the present study aims to investigate how DDIs and time availability affect patient trust in clinical pharmacists and how patient trust influences patient satisfaction and cooperation between patients and clinical pharmacists. Sample data of 741 patients in central Taiwan hospitals were analyzed, and the results of structural equation modeling showed that DDIs and time availability positively affect patient trust, which, in turn, positively influenced patient satisfaction and cooperation between patients and clinical pharmacists. Overall, the results indicated that patient satisfaction is an important predictor of cooperation between patients and clinical pharmacists.
Goals and Principles of Providers Working with People Experiencing Homelessness: A Comparison Between Housing First and Traditional Staircase Services in Eight European Countries
Authors: Gaboardi Marta , Lenzi Michela , Disperati Francesca , Santinello Massimo , Vieno Alessio , Tinland Aurélie , Vargas-Moniz Maria , Spinnewijn Freek , O’Shaughnessy Branagh , Wolf Judith , Bokszczanin Anna , Bernad Roberto , Beijer Ulla , Ornelas José , Shinn Marybeth ,   HOME-EU Consortium Study Group
Published: May 2019

The implementation and adaptation of the Housing First (HF) model represented profound changes the structure and delivery, goals, and principles of homeless services. These features of homeless services directly influence providers, their work performance and the clients’ outcomes. The present research, conducted in eight European countries, investigated how social providers working in HF or TS (Traditional Staircase) describe and conceptualize the goals and the principles of their services. Data were collected through 29 focus group discussions involving 121 providers. The results showed that HF and TS had similar and different goals for their clients in the following areas: support, social integration, satisfaction of needs, housing, and well-being. HF providers emphasized clients’ autonomy and ability to determine their personal goals, with housing being considered a start on the path of recovery, while TS were more focused on individual clients’ basic needs with respect to food, health and finding temporary accommodations. HF providers privileged the person-centered approach and housing as a right, while TS providers were more focused on helping everyone. Implications of the results are discussed as suggestions both for practice and for research.
A Scoping Review of Epidemiological, Ergonomic, and Longitudinal Cohort Studies Examining the Links between Stair and Bathroom Falls and the Built Environment
Authors: Edwards Nancy , Dulai Joshun , Rahman Alvi
Published: May 2019

Stair and bathroom falls contribute to injuries among older adults. This review examined which features of stairs and bathrooms have been assessed in epidemiological, ergonomic, and national aging studies on falls or their risk factors. Epidemiological and ergonomic studies were eligible if published from 2006–2017, written in English, included older persons, and reported built environment measures. The data extracted included the following: study population and design, outcome measures, and stair and bathroom features. National aging studies were eligible if English questionnaires were available, and if data were collected within the last 10 years. Sample characteristics; data collection methods; and data about falls, the environment, and assistive device use were extracted. There were 114 eligible articles assessed—38 epidemiologic and 76 ergonomic. Among epidemiological studies, 2 assessed stair falls only, 4 assessed bathroom falls only, and 32 assessed falls in both locations. Among ergonomic studies, 67 simulated stairs and 9 simulated bathrooms. Specific environmental features were described in 14 (36.8%) epidemiological studies and 73 (96%) ergonomic studies. Thirteen national aging studies were identified—four had stair data and six had bathroom data. Most epidemiologic and national aging studies did not include specific measures of stairs or bathrooms; the built environment descriptions in ergonomic studies were more detailed. More consistent and detailed environmental measures in epidemiologic and national aging studies would better inform fall prevention approaches targeting the built environment.
Post-Traumatic Stress among Evacuees from the 2016 Fort McMurray Wildfires: Exploration of Psychological and Sleep Symptoms Three Months after the Evacuation
Authors: Belleville Genevieve , Ouellet Marie-Christine , Morin Charles M.
Published: May 2019

This study documents post-traumatic stress symptoms after the May 2016 wildfires in Fort McMurray (Alberta, Canada). A sample of 379 evacuees completed an online questionnaire from July to September 2016, and a subsample of 55 completed a psychiatric/psychological diagnostic interview. According to a self-report questionnaire, 62.5% of respondents had a provisional post-traumatic stress disorder (PTSD). The interview confirmed that 29.1% met criteria for PTSD, 25.5% for depression, and 43.6% for insomnia; in most cases, insomnia was definitely or probably related to the fires. Traumatic exposure may elicit or exacerbate sleep problems, which are closely associated with PTSD after a disaster.
Can Low-Level Exposure to Radiofrequency Fields Effect Cognitive Behaviour in Laboratory Animals? A Systematic Review of the Literature Related to Spatial Learning and Place Memory
Authors: Sienkiewicz Zenon , van Rongen Eric
Published: May 2019

This review considers whether exposure to low-level radiofrequency (RF) fields, mostly associated with mobile phone technology, can influence cognitive behaviour of laboratory animals. Studies were nominated for inclusion using an a priori defined protocol with preselected criteria, and studies were excluded from analysis if they did not include sufficient details about the exposure, dosimetry or experimental protocol, or if they lacked a sham-exposed group. Overall, 62 studies were identified that have investigated the effects of RF fields on spatial memory and place learning and have been published since 1993. Of these, 17 studies were excluded, 20 studies reported no significant field-related effects, 21 studies reported significant impairments or deficits, and four studies reported beneficial consequences. The data do not suggest whether these outcomes are related to specific differences in exposure or testing conditions, or simply represent chance. However, some studies have suggested possible molecular mechanisms for the observed effects, but none of these has been substantiated through independent replication. Further behavioural studies could prove useful to resolve this situation, and it is suggested that these studies should use a consistent animal model with standardized exposure and testing protocols, and with detailed dosimetry provided by heterogeneous, anatomically-realistic animal models.
Skeletal Muscle Dysfunction and Exercise Intolerance in Children Treated with Haematopoietic Stem Cell Transplant—A Pilot Feasibility Study
Authors: West Sarah L. , White Gillian , Caterini Jessica E. , Rayner Tammy , Schechter Tal , Nathan Paul C. , Wells Greg D.
Published: May 2019

Haematopoietic stem cell transplant (HSCT) is an intensive therapy for some pediatric hematological illnesses. Survivors are at risk for adverse effects including exercise intolerance. Peripheral tissue dysfunction may contribute to exercise intolerance; therefore, we examined the feasibility of a magnetic resonance spectroscopy (MRS) protocol to evaluate skeletal muscle metabolism in children post-HSCT. We measured demographic characteristics, aerobic exercise capacity (YMCA protocol), and skeletal muscle function in response to exercise (MRS; Siemens 3T MRI) in five children post-allogeneic HSCT and five age/body mass index-matched healthy controls (HCs). The mean age (± standard deviation) of the HSCT group and HC group were 11 ± 1.2 and 12.8 ± 2.4 years, respectively. Children post-HSCT had a lower peak aerobic exercise capacity compared to HCs (27.8 ± 3.4 vs. 40.3 ± 8.1 mL kg−1 min−1, respectively; p = 0.015). Exercise MRS testing protocols were successfully completed by all HSCT and HC participants; however, MRS-derived skeletal muscle metabolism variables were not different between the two groups. In conclusion, the use of exercise protocols in conjunction with MRS to assess peripheral skeletal muscle metabolism was achievable in children post-HSCT. In the future, larger studies should determine if skeletal muscle function is associated with exercise capacity in children post-HSCT.
Impact of Stressful Events on Motivations, Self-Efficacy, and Development of Post-Traumatic Symptoms among Youth Volunteers in Emergency Medical Services
Authors: Roditi Eleni , Bodas Moran , Jaffe Eli , Knobler Haim Y. , Adini Bruria
Published: May 2019

During the last decades, Israeli emergency medical services (EMS) personnel has been exposed to different potentially traumatic events, including mass terror attacks. The aims of the present study were to identify how potentially traumatic events affect young volunteers in their motivation to volunteer and their perceived self-efficacy while being at risk of developing post-traumatic symptoms. The final sample included 236 Magen David Adom (MDA, the "Israeli Red Cross") youth volunteers. The study evaluated their motivational factors for volunteering, perceived self-efficacy, participation in potentially traumatic events, and post-traumatic symptoms. Over two-thirds of the volunteers participated in a traumatic event on duty. Volunteers who were involved in potentially stressful events scored higher levels of post-traumatic symptoms, though still very low and subclinical. Nonetheless, participating in stressful events contributed to an increased sense of self-efficacy. No difference in post-traumatic symptom levels was observed between volunteers who partook in mass casualty incidents and those who did not. The results demonstrate that MDA youth volunteers may mostly benefit from participating in situations requiring the administration of emergency medicine, even stressful ones. They may help to find ways to empower the volunteers and increase their resilience.
Can Forum Play Contribute to Counteracting Abuse in Health Care? A Pilot Intervention Study in Sri Lanka
Authors: Swahnberg Katarina , Zbikowski Anke , Wijewardene Kumudu , Josephson Agneta , Khadka Prembarsha , Jeyakumaran Dinesh , Mambulage Udari , Infanti Jennifer J.
Published: May 2019

Obstetric violence refers to the mistreatment of women in pregnancy and childbirth care by their health providers. It is linked to poor quality of care, lack of trust in health systems, and adverse maternal and neonatal outcomes. Evidence of interventions to reduce and prevent obstetric violence is limited. We developed a training intervention using a participatory theatre technique called Forum Play inspired by the Theatre of the Oppressed for health providers in Sri Lanka. This paper assesses the potential of the training method to increase staff awareness of obstetric violence and promote taking action to reduce or prevent it. We conducted four workshops with 20 physicians and 30 nurses working in three hospitals in Colombo, Sri Lanka. Participants completed a questionnaire before and three-to-four months after the intervention. At follow-up, participants more often reported that they had been involved in situations of obstetric violence, indicating new knowledge of the phenomenon and/or an increase in their ability to conceptualise it. The intervention appears promising for improving the abilities of health care providers to recognise obstetric violence, the first step in counteracting it. The study demonstrates the value of developing further studies to assess the longitudinal impacts of theatre-based training interventions to reduce obstetric violence and, ultimately, improve patient care.
Malaria Transmission around the Memve’ele Hydroelectric Dam in South Cameroon: A Combined Retrospective and Prospective Study, 2000–2016
Authors: Mbakop Lili R. , Awono-Ambene Parfait H. , Mandeng Stanislas E. , Ekoko Wolfgang E. , Fesuh Betrand N. , Antonio-Nkondjio Christophe , Toto Jean-Claude , Nwane Philippe , Fomena Abraham , Etang Josiane
Published: May 2019

Dam constructions are considered a great concern for public health. The current study aimed to investigate malaria transmission in the Nyabessan village around the Memve’ele dam in South Cameroon. Adult mosquitoes were captured by human landing catches in Nyabessan before and during dam construction in 2000–2006 and 2014–2016 respectively, as well as in the Olama village, which was selected as a control. Malaria vectors were morphologically identified and analyzed for Plasmodium falciparum circumsporozoite protein detection and molecular identification of Anopheles (A.) gambiae species. Overall, ten malaria vector species were identified among 12,189 Anopheles specimens from Nyabessan (N = 6127) and Olama (N = 6062), including A. gambiae Giles (1902), A. coluzzii Coetzee (2013), A. moucheti Evans (1925), A. ovengensis Awono (2004), A. nili Theobald (1903), A. paludis Theobald (1900), A. zieanni, A. marshallii Theobald (1903), A. coustani Laveran (1900), and A. obscurus Grünberg (1905). In Nyabessan, A. moucheti and A. ovengensis were the main vector species before dam construction (16–50 bites/person/night-b/p/n, 0.26–0.71 infective bites/person/night-ib/p/n) that experienced a reduction of their role in disease transmission in 2016 (3–35 b/p/n, 0–0.5 ib/p/n) (p < 0.005). By contrast, the role of A. gambiae s.l. and A. paludis increased (11–38 b/p/n, 0.75–1.2 ib/p/n) (p < 0.01). In Olama, A. moucheti remained the main malaria vector species throughout the study period (p = 0.5). These findings highlight the need for a strong vector-borne disease surveillance and control system around the Memve’ele dam.
Determinants of Tetanus Vaccination among Adult Immigrants: Findings from the Portuguese National Health Survey 2014
Authors: Moura Sofia , Martins Maria do Rosário O.
Published: May 2019

Vaccination is an effective strategy to prevent tetanus, and in Portugal this service is provided free of charge. Despite this, immigrants reported lower tetanus vaccination coverage than did Portuguese natives. The objective of this study was to identify sociodemographic, migration-related, and access-to-care factors associated with tetanus vaccination coverage among adult immigrants, using data from the Portuguese National Health Survey 2014. For the sample of 1277 immigrants aged ≥18 years, we estimated self-reported tetanus vaccination within the preceding 10 years and its determinants using complex samples logistic regression. The overall self-reported tetanus vaccination coverage was 79.5% (95% CI: 75.8–82.8). Age (adjusted odd ratio (aOR) per 1 year age increase = 0.97, 95% CI: 0.95–0.99), higher household income per adult (aOR = 0.42, 95% CI: 0.19–0.96), having Portuguese citizenship (aOR = 2.30, 95% CI: 1.25–4.24), having private health insurance (aOR = 1.99, 95% CI: 1.06–3.71), and contact with family/general physician in the last 12 months (aOR = 1.59, 95% CI: 1.01–2.51) were associated with self-reported tetanus vaccination coverage among adult immigrants. We also found significant disparities in coverage between regions of residence. This study identified several determinants associated with self-reported tetanus vaccination coverage among adult immigrants in Portugal. These findings may help policymakers to design specific interventions to increase tetanus vaccination coverage among this population.
Relationship between Body Image and Body Weight Control in Overweight ≥55-Year-Old Adults: A Systematic Review
Authors: Bouzas Cristina , Bibiloni Maria del Mar , Tur Josep A.
Published: May 2019

Objective: To assess the scientific evidence on the relationship between body image and body weight control in overweight ≥55-year-old adults. Methods: The literature search was conducted on MEDLINE database via PubMed, using terms related to body image, weight control and body composition. Inclusion criteria were scientific papers, written in English or Spanish, made on older adults. Exclusion criteria were eating and psychological disorders, low sample size, cancer, severe diseases, physiological disorders other than metabolic syndrome, and bariatric surgery. Results: Fifty-seven studies were included. Only thirteen were conducted exclusively among ≥55-year-old adults or performed analysis adjusted by age. Overweight perception was related to spontaneous weight management, which usually concerned dieting and exercising. More men than women showed over-perception of body image. Ethnics showed different satisfaction level with body weight. As age increases, conformism with body shape, as well as expectations concerning body weight decrease. Misperception and dissatisfaction with body weight are risk factors for participating in an unhealthy lifestyle and make it harder to follow a healthier lifestyle. Body image disturbance also made it more likely to underreport calorie intake. Conclusions: Aging is associated with a decrease in weight concerns and lower overweight perception, especially in women. However, when designing a program to improve body image in overweight ≥55-year-old adults, three items ought to be considered: physical activity, dietary and behavioral treatments.
Estimation of Effects of Recent Macroprudential Policies in a Sample of Advanced Open Economies
Authors: Nymoen Ragnar , Pedersen Kari , Sjåberg Jon Ivar
Published: May 2019

We used a time-series cross-section dataset to test several hypotheses pertaining to the role of macroprudential policy instruments in the management of the financial cycle in advanced open economies. The short-run effects are most significant for caps on loan to value and income (LTV and LTI) and risk weights (RW). The long-run coefficients of credit growth with respect to the indicators of amortisation requirements (Amort) and RW are also significant. The estimation results when house price growth is the dependent variable are consistent with these results. Our findings do not support that Basel III type countercyclical buffer (CCyB) has affected credit growth, and we suggest that the variable is mainly a control in our dataset. In that interpretation, it is interesting that the estimated coefficients of the other instruments are robust with respect to exclusion of CCyB from the empirical models. The main results are also robust to controls in the form of impulse indicator saturation (IIS), which we employed as a novel estimation method for macro panels.
LADM Based Utility Network Cadastre in Serbia
Authors: Radulović Aleksandra , Sladić Dubravka , Govedarica Miro , Ristić Aleksandar , Jovanović Dušan
Published: May 2019

The utility network cadastre in Serbia is the main register of utility lines and the rights to them. The Law on State Survey and Cadastre states the necessity for implementing a unified information system of both a real estate and utility network cadastre, but this has not been achieved in practice. The reasons for such a unified information system are to ensure easier maintenance of the rights of both the utilities and properties located above or below them, to ensure more efficient procedures for obtaining the consent for placement, repair, or removal of the utility line, to prevent procedures being executed based on outdated data, to build an information system as the law prescribes, and to facilitate the business processes in the Serbian geodetic authority, since it is responsible for both registers. Therefore, an already-developed LADM (Land Administration Domain Model)-based country profile for Serbia should be extended to include information from the utility network cadastre. An analysis of Serbian legislation showed the necessity of extending the class set of the utility network cadastre by further specialization of the LADM LA_LegalSpaceUtilityNetwork class. Furthermore, such a system will support the maintenance of utility network data. In practice, when there is a change made on utility lines by the right holders, it is necessary to implement the change in the register. In many situations, this is not done, and the actual state does not correspond to the one in the register. Usually, modern technologies, such as ground penetrating radar (GPR) and LIDAR, are used for data acquisition in order to provide an update of the utility network data. Since these technologies produce 3D data, we analyzed how to link that data to the traditional 2D spatial paradigm.
An Occupancy Simulator for a Smart Parking System: Developmental Design and Experimental Considerations
Authors: Mendoza-Silva Germán Martín , Gould Michael , Montoliu Raul , Torres-Sospedra Joaquín , Huerta Joaquín
Published: May 2019

This paper presents the development of a parking occupancy simulator to support a smart parking system. The simulator uses an agent-based approach to model drivers who follow activity plans and who may or may not use the smart parking system. We illustrate how the process of developing our simulator helped in the design and implementation of the smart parking system components. The paper also shows how the simulator was used to study the possible usage of the smart parking system in a university campus, foreseeing (1) support for the smart parking system’s overall suitability, (2) reservation guarantee violation problems, and (3) the value of using total traveled distance as a metric for the smart parking evaluation. The experience presented in this paper may prove valuable to teams planning the development of a smart parking system for similar contexts.
Voxel-based 3D Point Cloud Semantic Segmentation: Unsupervised Geometric and Relationship Featuring vs Deep Learning Methods
Authors: Poux Florent , Billen Roland
Published: May 2019

Automation in point cloud data processing is central in knowledge discovery within decision-making systems. The definition of relevant features is often key for segmentation and classification, with automated workflows presenting the main challenges. In this paper, we propose a voxel-based feature engineering that better characterize point clusters and provide strong support to supervised or unsupervised classification. We provide different feature generalization levels to permit interoperable frameworks. First, we recommend a shape-based feature set (SF1) that only leverages the raw X, Y, Z attributes of any point cloud. Afterwards, we derive relationship and topology between voxel entities to obtain a three-dimensional (3D) structural connectivity feature set (SF2). Finally, we provide a knowledge-based decision tree to permit infrastructure-related classification. We study SF1/SF2 synergy on a new semantic segmentation framework for the constitution of a higher semantic representation of point clouds in relevant clusters. Finally, we benchmark the approach against novel and best-performing deep-learning methods while using the full S3DIS dataset. We highlight good performances, easy-integration, and high F1-score (> 85%) for planar-dominant classes that are comparable to state-of-the-art deep learning.
Online Map Services: Contemporary Cartography or a New Cartographic Culture?
Authors: Skopeliti Andriani , Stamou Leda
Published: May 2019

In this paper, online map services are reviewed from a cartographic point of view. The most popular online map services are selected based on worldwide website traffic data, provided by specialized sites, such as Similarweb, in terms of global coverage and popularity among users. Online map services are commented based on cartographic principles, conventions and traditional practices addressing topics, such as: Cartographic projection, orientation, scale, marginalia, content (thematic layers), symbology, generalization, annotation, color use and overall map design. Color schemes utilized in web maps are discussed in more detail, since based on studies concerning the selection of the preferable map by experts and laymen, color is undisputedly the most frequently mentioned factor. It can be stated that online map services generally adopt well-known cartographic practices, which are not always applied as expected. Moreover, suggestions for the improvement of online map services are made regarding cartographic projection, legend, content, symbolization, color, etc.
Why Shape Matters—On the Inherent Qualities of Geometric Shapes for Cartographic Representations
Authors: Klettner Silvia
Published: May 2019

All human communication involves the use of signs. By following a mutually shared set of signs and rules, meaning can be conveyed from one entity to another. Cartographic semiology provides such a theoretical framework, suggesting how to apply visual variables with respect to thematic content. However, semiotics does not address how the choice and composition of such visual variables may lead to different connotations, interpretations, or judgments. The research herein aimed to identify perceived similarities between geometric shape symbols as well as strategies and processes underlying these similarity judgments. Based on a user study with 38 participants, the (dis)similarities of a set of 12 basic geometric shapes (e.g., circle, triangle, square) were examined. Findings from cluster analysis revealed a three-cluster configuration, while multidimensional scaling further quantified the proximities between the geometric shapes in a two-dimensional space. Qualitative and quantitative content analyses identified four strategies underlying the participants’ similarity judgments, namely visual, affective, associative, and behavioral strategies. With the findings combined, this research provides a differentiated perspective on shape proximities, cognitive relations, and the processes involved.
Dynamic Chloroplast Genome Rearrangement and DNA Barcoding for Three Apiaceae Species Known as the Medicinal Herb “Bang-Poong”
Authors: Lee Hyun Oh , Joh Ho Jun , Kim Kyunghee , Lee Sang-Choon , Kim Nam-Hoon , Park Jee Young , Park Hyun-Seung , Park Mi-So , Kim Soonok , Kwak Myounghai , Kim Kyu-yeob , Lee Woo Kyu , Yang Tae-Jin
Published: May 2019

Three Apiaceae species Ledebouriella seseloides, Peucedanum japonicum, and Glehnia littoralis are used as Asian herbal medicines, with the confusingly similar common name “Bang-poong”. We characterized the complete chloroplast (cp) genomes and 45S nuclear ribosomal DNA (45S nrDNA) sequences of two accessions for each species. The complete cp genomes of G. littoralis, L. seseloides, and P. japonicum were 147,467, 147,830, and 164,633 bp, respectively. Compared to the other species, the P. japonicum cp genome had a huge inverted repeat expansion and a segmental inversion. The 45S nrDNA cistron sequences of the three species were almost identical in size and structure. Despite the structural variation in the P. japonicum cp genome, phylogenetic analysis revealed that G. littoralis diverged 5–6 million years ago (Mya), while P. japonicum diverged from L. seseloides only 2–3 Mya. Abundant copy number variations including tandem repeats, insertion/deletions, and single nucleotide polymorphisms, were found at the interspecies level. Intraspecies-level polymorphism was also found for L. seseloides and G. littoralis. We developed nine PCR barcode markers to authenticate all three species. This study characterizes the genomic differences between L. seseloides, P. japonicum, and G. littoralis; provides a method of species identification; and sheds light on the evolutionary history of these three species.
Applicability of Supraclavicular Oxygenated and Total Hemoglobin Evaluated by Near-Infrared Time-Resolved Spectroscopy as Indicators of Brown Adipose Tissue Density in Humans
Authors: Nirengi Shinsuke , Fuse Sayuri , Amagasa Shiho , Homma Toshiyuki , Kime Ryotaro , Kuroiwa Miyuki , Endo Tasuki , Sakane Naoki , Matsushita Mami , Saito Masayuki , Kurosawa Yuko , Hamaoka Takafumi
Published: May 2019

Brown adipose tissue (BAT) may potentially be used in strategies for preventing lifestyle-related diseases. We examine evidence that near-infrared time-resolved spectroscopy (NIRTRS) is capable of estimating human BAT density (BAT-d). The parameters examined in this study are total hemoglobin [total-Hb]sup, oxygenated Hb [oxy-Hb]sup, deoxygenated Hb [deoxy-Hb]sup, Hb O2 saturation (StO2sup), and the reduced scattering coefficient in the supraclavicular region (μs’sup), where BAT deposits can be located; corresponding parameters in the control deltoid region are obtained as controls. Among the NIRTRS parameters, [total-Hb]sup and [oxy-Hb]sup show region-specific increases in winter, compared to summer. Further, [total-Hb]sup and [oxy-Hb]sup are correlated with cold-induced thermogenesis in the supraclavicular region. We conclude that NIRTRS-determined [total-Hb]sup and [oxy-Hb]sup are useful parameters for evaluating BAT-d in a simple, rapid, non-invasive manner.
Monocyte Chemoattractant Protein-1, a Possible Biomarker of Multiorgan Failure and Mortality in Ventilator-Associated Pneumonia
Authors: Li Yia-Ting , Wang Yao-Chen , Lee Hsiang-Lin , Tsao Su-Chin , Lu Min-Chi , Yang Shun-Fa
Published: May 2019

Ventilator-associated pneumonia (VAP) leads to increased patients’ mortality and medical expenditure. Monocyte chemoattractant protein-1 (MCP-1) plays a role in the pathogenesis of lung inflammation and infection. Therefore, the plasma concentration of MCP-1 was assessed and correlated with the clinical course in VAP patients. This retrospective observational study recruited 45 healthy volunteers, 12 non-VAP subjects, and 30 VAP patients. The diagnostic criteria for VAP were based on the American Thoracic Society guidelines, and the level of plasma MCP-1 was determined by ELISA. Plasma MCP-1 concentration was significantly elevated in the acute stage in VAP patients when compared with the control (p < 0.0001) and non-VAP patient groups (p = 0.0006). Subsequently, it was remarkably decreased following antibiotic treatment. Moreover, plasma MCP-1 concentration was positively correlated with indices of pulmonary dysfunction, including the lung injury score (p = 0.02) and the oxygenation index (p = 0.02). When patients with VAP developed adult respiratory distress syndrome (ARDS), their plasma MCP-1 concentrations were significantly higher than those of patients who did not develop ARDS (p = 0.04). Moreover, plasma MCP-1 concentration was highly correlated with organ failure scores, including simplified acute physiology score II (SAPS II, p < 0.0001), sequential organ failure assessment score (SOFA, p < 0.0001), organ dysfunctions and/or infection (ODIN, p < 0.0001), predisposition, insult response and organ dysfunction (PIRO, p = 0.005), and immunodeficiency, blood pressure, multilobular infiltrates on chest radiograph, platelets and hospitalization 10 days before onset of VAP (IBMP-10, p = 0.004). Our results demonstrate that plasma MCP-1 is an excellent marker for recognizing VAP when the cut-off level is set to 347.18 ng/mL (area under the curve (AUC) = 0.936, 95% CI = 0.863–0.977). In conclusion, MCP-1 not only could be a biological marker related to pulmonary dysfunction, organ failure, and mortality in patients with VAP, but also could be used for early recognition of VAP.
A Composite Chitosan-Reinforced Scaffold Fails to Provide Osteochondral Regeneration
Authors: Roffi Alice , Kon Elizaveta , Perdisa Francesco , Fini Milena , Di Martino Alessandro , Parrilli Annapaola , Salamanna Francesca , Sandri Monica , Sartori Maria , Sprio Simone , Tampieri Anna , Marcacci Maurilio , Filardo Giuseppe
Published: May 2019

Several biomaterials have recently been developed to address the challenge of osteochondral regeneration. Among these, chitosan holds promises both for cartilage and bone healing. The aim of this in vivo study was to evaluate the regeneration potential of a novel hybrid magnesium-doped hydroxyapatite (MgHA), collagen, chitosan-based scaffold, which was tested in a sheep model to ascertain its osteochondral regenerative potential, and in a rabbit model to further evaluate its ability to regenerate bone tissue. Macroscopic, microtomography, histology, histomorphometry, and immunohistochemical analysis were performed. In the sheep model, all analyses did not show significant differences compared to untreated defects (p > 0.05), with no evidence of cartilage and subchondral bone regeneration. In the rabbit model, this bone scaffold provided less ability to enhance tissue healing compared with a commercial bone scaffold. Moreover, persistence of scaffold material and absence of integration with connective tissue around the scaffolds were observed. These results raised some concerns about the osteochondral use of this chitosan composite scaffold, especially for the bone layer. Further studies are needed to explore the best formulation of chitosan-reinforced composites for osteochondral treatment.