bluuebunny/crossref_metadata_2025 huggingface dataset:
It’s a mismatch! Overeducation and career mobility in Germany
Authors: Roller Christiane , Rulff Christian , Tamminga Michael M.
Published: February 2020

The career mobility model suggests that overeducated workers are more prone to take up on-the-job training, to climb up the career ladder, or to leave to professions more suitable to their educational level. Our empirical analysis, using the German SOEP, confirms this theory for Germany. Comparing adequately qualified and overqualified workers in jobs that require the same level of formal qualification indicates that overeducated workers have a higher probability to take up on-the-job training and have a higher probability to move to jobs that better match their educational level. Furthermore, we find that overeducated workers experience higher wage growth than their adequately educated colleagues.
Senecio serratuloides extract prevents the development of hypertension, oxidative stress and dyslipidemia in nitric oxide-deficient rats
Authors: Tata Charlotte Mungho , Sewani-Rusike Constance Rufaro , Oyedeji Opeopluwa Oyehan , Mahlakata Fikile , Shauli Mathulo , Nkeh-Chungag Benedicta Ngwenchi
Published: February 2020

Background

Hypertension is a silent killer with no obvious signs and symptoms; thus, it is crucial to prevent its development. Oxidative stress and hyperlipidemia are associated risk factors for developing hypertension. This study aimed at investigating the role of a crude extract of Senecio serratuloides in preventing the development of hypertension, oxidative stress and hyperlipidemia in a rat model of nitric oxide deficiency.

Methods

Female Wistar rats were co-treated with Nω-Nitro L-arginine methyl ester (L-NAME) (40 mg/kg) and the hydroethanolic extract of S. Serratuloides (HESS150 or HESS300 mg/kg) for 4 weeks. Twenty-hour urine samples were collected weekly during the study. At the end of the study serum, heart and kidneys were harvested for biochemical and histopathological analysis.

Results

The higher dose (300 mg/kg) of the extract was more effective in preventing increase in systolic (p<0.001) and diastolic (p<0.05) blood pressure. At the end of the treatment period HESS300 treated rats had significantly (p<0.01) higher concentration of creatinine (91.24 ± 6 mg/dL) in urine and significantly (6.36 ± 0.4 mg/24 h; 0.001) lower proteinuria compared to L-NAME control rats (55.75 ± 8 mg/dL and 18.92 ± 2 mg/24 h, respectively). Creatinine clearance and glomerular filtration rate were lower in the L-NAME control group compared to all treatment groups. HESS300 prevented L-NAME-induced decrease in serum angiotensin II concentration, significantly decreased malondialdehyde concentration in serum (p<0.05) and kidneys (p<0.001). It also significantly (p<0.001) decreased low-density lipoprotein concentration while increasing the concentration of high-density lipoprotein cholesterol. It showed cardio- and reno-protective effects and significantly (p<0.01) prevented collagen deposition in these target organs.

Conclusion

These findings demonstrate the potential of S. Serratuloides in protecting rats from developing hypertension, hyperlipidemia and oxidative stress.
The crystal structure of diaqua-bis(6-aminopicolinato-κ2
N,O)magnesium(II), C12H14O6N4Mg
Authors: Xi-Shi Tai , Xiao-Jing Zhou , Li-Li Liu , Shu-Hua Cao , Li-Hua Wang
Published: February 2020

C12H14O6N4Mg, monoclinic, P21/c (no. 14), a = 8.2501(10) Å, b = 12.7943(12) Å, c = 7.1562(7) Å, β = 113.912(13)°, V = 690.53(14) Å3, Z = 2, R
gt(F) = 0.0386, wR
ref(F
2) = 0.0921, T = 293(2) K.
On the left periphery of Spanish indirect interrogatives
Authors: García-Núñez José María
Published: February 2020

Spanish doubly filled complementizer (DFComp) clauses differ from plain embedded questions in a number of respects (availability of discourse-related projections, islandhood, sequence of tenses, licensing of discourse particles). I argue that the contrast is caused by the presence in the left periphery of these clauses of an illocutionary projection (Haegeman 2004, 2006; Coniglio and Zegrean 2012; Woods 2016b) between the leftmost projection, here identified as Haegeman’s (2004) SubP, and the criterial interrogative projections (InterP and QembP). This illocutionary projection prevents syncretism of the clause-typing and the criterial projections, the default option in plain embedded clauses. This not only explains the range of structural phenomena differentiating DFComp clauses and embedded questions, but also a key semantic property of the former, namely their speech-act denotation. Finally, DFComp clauses are compared with plain embedded questions displaying root behavior under first-person matrix subjects and with English inverted embedded questions. Both are shown to pose minimal variants of the structural pattern proposed for DFComp clauses.
The correlation between methylenetetrahydrofolate reductase gene 677C > T polymorphism and fetal congenital defects: A meta-analysis
Authors: Li Dexia , Wang Enxia , Gao Xia , Li Ping
Published: February 2020

Objective To investigate the correlation between the methylenetetrahydrofolate reductase (MTHFR) gene 677C> T polymorphism and fetal congenital defects.

Method Original studies relevant to the MTHFR gene 677C>T single nucleotide polymorphism and fetal congenital defects were systematically searched in the electronic databases of Medline, EMBSE and China National Knowledge Infrastructure (CNKI). All relevant publications were screened for inclusion in the present work. The correlation between the MTHFR gene 677C > T single nucleotide polymorphism and the occurrence of fetal congenital defects was expressed as an odds ratio (OR) and its 95% confidence interval (95% CI). Publication bias was assessed by Begg’s funnel plot and Egger’s line regression test.

Results Nineteen case-control studies were ultimately included in the present meta-analysis. The pooled results indicated that the general risk of fetal congenital defects was significantly elevated in subjects with the 677T allele of the MTHFR gene in dominant (OR=1.07,95%CI:1.03-1.12, P<0.05), homozygous (OR=1.17,95%CI:1.06-1.30, P<0.05) and recessive genetic models (OR=1.16,95%CI:1.03-1.31, P<0.05) through the random effect method. However, significant publication bias was identified upon pooling the individual data and evaluating the correlation.

Conclusion According to the present evidence, the MTHFR gene 677C>T single nucleotide polymorphism is correlated with poor pregnancy outcomes, and subjects with the T allele have an increased risk of developing general fetal congenital defects.
Die Vielfalt der Beobachter Zum Zusammenhang von Kontingenz und Quantifizierung in der Beobachtung der Zukunft der Wirtschaft
Authors: Beyrle Judith
Published: February 2020

Die Feststellung, dass die präzise Vorausschau der Wirtschaftsentwicklung nicht möglich ist, weil diese Entwicklung abhängig von ihrer Beobachtung ist und sich dadurch selbst mit in Rechnung stellen müsste, mündet bislang in der Empfehlung, reflexive und explizit orientierende Formen des Umgangs mit Prognosen zu wählen. Der vorliegende Aufsatz verschränkt die theoretischen Ausarbeitungen einer systemtheoretisch inspirierten Wirtschaftssoziologie mit der Beobachtung der Verwendung der Prognosevielfalt in Tageszeitungen und kommt daraufhin zu dem Schluss, dass die Zahlenförmigkeit der Prognosen Vergleiche eröffnet, welche die Perspektivität der Beobachtungen vergleichbar macht und somit relativiert.
Distinktion und Inklusion. Die Beobachtung von „Diversität“ im Recht
Authors: Bora Alfons
Published: February 2020

Rechtsprechung und Literatur lassen ein steigendes Interesse an Phänomenen der Diversität erkennen. Aus rechtssoziologischer Sicht greifen sie damit nicht nur einen Begriff aus der politischen Praxis auf, sondern verweisen auf ein tiefer liegendes Problem, das gewissermaßen bei der Entstehung der Rechtssoziologie Pate stand. Es betrifft den Umgang mit Multinormativität als Herausforderung für das Recht, vor allem aber auch für die rechtssoziologische Theorie. Ein sehr knapper Abriss der in der Rechtssoziologie vertretenen Lösungen führt zur Diskussion der systemtheoretischen Differenzierungstheorie. Auch sie, so das Ergebnis, wirft Anschlussfragen auf, etwa diejenige nach der Rolle hybrider Grenzorganisationen und deren Übersetzungsleistungen im Umgang mit Diversität.
An Observational Analysis Quantifying the Distance of Supercell-Boundary Interactions in the Great Plains
Authors: Magee Kathleen , Davenport Casey
Published: February 2020

Several case studies and numerical simulations have hypothesized that baroclinic boundaries provide enhanced horizontal and vertical vorticity, wind shear, helicity, and moisture that induce stronger updrafts, higher reflectivity, and stronger low-level rotation in supercells. However, the distance at which a surface boundary will provide such enhancement is less well-defined. Previous studies have identified enhancement at distances ranging from 10 km to 200 km, and only focused on tornado production and intensity, rather than all forms of severe weather. To better aid short-term forecasts, the observed distances at which supercells produce severe weather in proximity to a boundary needs to be assessed.
In this study, the distance between a large number of observed supercells and nearby surface boundaries (including warm fronts, stationary fronts, and outflow boundaries) is measured throughout the lifetime of each storm; the distance at which associated reports of large hail and tornadoes occur is also collected. Statistical analyses assess the sensitivity of report distributions to report type, boundary type, boundary strength, angle of interaction, and direction of storm motion relative to the boundary. Additionally, the range at which each type of severe weather is produced for each boundary is identified to provide a useful operational tool for forecasters. Notably, tornadoes are more likely to be produced closer to a boundary than severe hail. Overall, the observations point to a unique range at which severe weather occurs for each boundary and report type.
Business and Leisure “Bleisure” in Organization: Antecedents and Outcomes
Authors: Adhiatma Ardian , Muna Nailil , Fachrunnisa Olivia
Published: February 2020

The purpose of this study is to explore the concept of bleisure (business and leisure) in an organization along with its antecedents and outcomes. Bleisure is a combination of completing work and entertainment or a pleasant situation at the same time. The sample used in this study were 106 respondents who work in Event Organizer (EO). Data collection methods in this study used questionnaires. Data was analyzed by using regression test. The results of this study indicate that if people work in an organization that combines business and leisure (bleisure), they will have the creativity and high innovation performance, and the application of business and leisure (bleisure) can be achieved through mobile working style and gamification. Bleisure or a combination of fun activities and work can enhance creative intelligence and innovation performance for individuals in completing work, every person will be more creative and innovative. Leisure and work are related things, when individuals are burdened with assignments, the application of leisure in an organization is one of the effective things.
Insatisfaccion por la imagen corporal y baja autoestima por la apariencia física en estudiantes de la facultad de medicina de la Universidad de los Andes del Estado Merida Venezuela
Authors: López Atencio Pedro , Prado P. José R. , Montilla Mercedes , Molina Viana Zarela , Da Silva Glenda , Arteaga Fanny
Published: February 2020

La presente investigación tuvo como propósito central evaluar la insatisfacción por la imagen corporal y su relación con la baja autoestima por la apariencia física en estudiantes de la Facultad de Medicina de La Universidad de Los Andes en Mérida Venezuela. El estudio fue de tipo no experimental correlacional. La muestra estuvo constituida por 189 estudiantes, 27% masculino y 73% femenino, con una edad promedio de 19,58 años ±1,57 (varones 19,81 años ± 1,74 y para las mujeres 20,24 años ± 1,76). Los participantes fueron seleccionados de los cursos del primer año de las carreras de: Medicina, Enfermería y Nutrición, los cuales fueron seleccionados de forma intencional. El instrumento empleado para determinar la Insatisfacción por la Imagen Corporal fue el Body Shape Questionnaire (Cooper y Taylor,  1987).  El método de Graffar Modificado fue utilizado para determinar el estrato socioeconómico de los participantes (Méndez y Méndez,  1994). A los datos se les aplicó el análisis descriptivo (frecuencia, porcentajes, media) e inferencial (ANOVA  de un solo factor a  través del  paquete estadístico SPSS versión 9.0). Entre los principales hallazgos en el estudio se pudo determinar una asociación estadísticamente significativa entre la insatisfacción con la imagen corporal, la baja autoestima por la apariencia física con el género χ2  (2, N= 189) = 9,686, p=0,008. A través de ANOVA se pudo determinar que las diferencias en las medias para los niveles de insatisfacción y baja autoestima con  la imagen corporal y el género son estadísticamente significativas, F=11,236; p=0,008, F=10,23; p=0,002 respectivamente. Conclusiones: los resultados obtenidos permiten sugerir sobre la relación que existe entre la insatisfacción y la baja autoestima por la apariencia física, existiendo un rechazo por la propia imagen corporal causada por la percepción distorsionada o no de la misma, lo que podría afectar la autoestima por la apariencia física.
Масові дослідження з використанням х-променів: перші кроки флюорографії
Authors: Кисільова Т. О.
Published: February 2020

У статті розглянуто передумови та перші спроби використання в медичній практиці рентгенівського випромінювання для масових досліджень органів грудної клітини. Значний поштовх для розробки методу такої спрямованості надала епідемія туберкульозу, що виникла в Європі під час Першої світової війни. Побудування нової діагностичної методики передбачало в першу чергу суттєве зниження собівартості отримання однієї світлини. Розв’язанням висунутої проблеми вбачалося фотографування об’єктів з флуоресцентного екрана з використанням звичайного фотоапарата та малоформатної плівки. Створення цинк-кадмій- сульфідних екранів усунуло останню перешкоду на шляху становлення методу масового дослідження органів грудної порожнини – флюорографії.

У 1937 р. бразильський рентгенолог Мануель Діас де Абреу першим провів масове профілактичне флюорографічне дослідження легенів мешканців Ріо-де- Жанейро. Його успіх надихнув науковців різних країн на власні розробки. В СРСР перше повідомлення про створення вітчизняного флюорографа з’явилося в 1939 р. за авторством Я. Л. Шика. Також значний внесок у розробку методу внесли К. В. Помельцов, В. Ф. Купріянов, Я. Л. Шехтман, Н. Ф. Заркевич та інші. Завдяки розробці та впровадженню флюорографічних досліджень у країнах Європи та Америки вдалося зупинити розповсюдження епідемії туберкульозу легенів та надати своєчасну допомогу широким верствам населення. Економічна та діагностична цінність методу дозволяє його використання й в сучасній медичній практиці.
“Family Values Don’t Stop at the Rio Grande . . .”: Can the Republican Party Convert Hispanic Voters?
Authors: Davison Donald
Published: February 2020

As the Hispanic community becomes increasingly important in American politics there are competing views about whether they can be converted to the Republican Party. One perspective argues that Hispanics’ religion and traditional social values makes them natural constituents of the Republican Party. Alternatively, Hispanics are primarily concerned about issues promoting their well-being and topics such as moral values or religion are private. We use a novel approach to test whether traditional social values might attract Hispanic voters to the Republican Party.  Using exit poll results for ballot propositions on moral issues from Arizona, Colorado, and Florida we find weak evidence that traditional values will convert Hispanics to the Republican Party. Instead, our results indicate that traditional social values issues reinforce the polarization between the two parties.
Avaliação da Reforma Curricular de um Curso de Medicina na Perspectiva dos Docentes
Authors: Pavan Maria Valéria , Senger Maria Helena , Marques Waldemar
Published: February 2020

ABSTRACT In 2006, the medical course of the Faculty of Medical Sciences and Health of PUC-SP (FCMS of PUC-SP) completely restructured its curriculum and pedagogical project and began to use active teaching/learning methods, centered on problem-based learning. There is often some resistance on the part of the teachers in relation to the changes, depending on the consequences for their daily practice. However, the participation of the teachers and their commitment to reform proposals are fundamental for them to occur and to be continually renewed. In this sense, this study had as objective to evaluate the teachers’ view of the FCMS of the PUC-SP medical course on the changes triggered by the curricular reform; the impact of these changes on their own work, on the quality of the course and on the graduate doctor and, the suggestions to improve the curriculum, as part of the ongoing goal to produce well-trained professionals adapted to the needs of the population and to the health care system. The data were obtained through a pre-tested semi-structured questionnaire, sent to the teachers working on the medical course. The second part of the questionnaire, object of this article, was to be answered only by the teachers who were already working before the curricular reform. Of the 178 teachers, 102 answered the questionnaire and, of these, 73 (71.6%) had already worked on the course before the curricular reform and answered the second part of the questionnaire. In general, the teachers have a positive view of the changes triggered by the reform, with emphasis on the active role of the student in the teaching/learning process and the growth provided to the teacher, induced by the pedagogical model chosen. They also consider that there has been an improvement in the quality of the course and the graduate doctor. Although well evaluated, the change to an interdisciplinary model and the deficiencies of the physical structure and equipment made available for the course complicate the work of the teacher. The difficulty in evaluating the student and the lack of a permanent teacher development plan appear as the main problems to be faced in the search for improving the course.
Assessment of the Curricular Reform of a Medical Course from the Faculty’s Perspective
Authors: Pavan Maria Valéria , Senger Maria Helena , Marques Waldemar
Published: February 2020

ABSTRACT In 2006, the medical course of the Faculty of Medical Sciences and Health of PUC-SP (FCMS of PUC-SP) completely restructured its curriculum and pedagogical project and began to use active teaching/learning methods, centered on problem-based learning. There is often some resistance on the part of the teachers in relation to the changes, depending on the consequences for their daily practice. However, the participation of the teachers and their commitment to reform proposals are fundamental for them to occur and to be continually renewed. In this sense, this study had as objective to evaluate the teachers’ view of the FCMS of the PUC-SP medical course on the changes triggered by the curricular reform; the impact of these changes on their own work, on the quality of the course and on the graduate doctor and, the suggestions to improve the curriculum, as part of the ongoing goal to produce well-trained professionals adapted to the needs of the population and to the health care system. The data were obtained through a pre-tested semi-structured questionnaire, sent to the teachers working on the medical course. The second part of the questionnaire, object of this article, was to be answered only by the teachers who were already working before the curricular reform. Of the 178 teachers, 102 answered the questionnaire and, of these, 73 (71.6%) had already worked on the course before the curricular reform and answered the second part of the questionnaire. In general, the teachers have a positive view of the changes triggered by the reform, with emphasis on the active role of the student in the teaching/learning process and the growth provided to the teacher, induced by the pedagogical model chosen. They also consider that there has been an improvement in the quality of the course and the graduate doctor. Although well evaluated, the change to an interdisciplinary model and the deficiencies of the physical structure and equipment made available for the course complicate the work of the teacher. The difficulty in evaluating the student and the lack of a permanent teacher development plan appear as the main problems to be faced in the search for improving the course.
Phase Ib Study of Crizotinib plus Pembrolizumab in Patients with Previously Untreated Advanced Non-Small Cell Lung Cancer with ALK Translocation
Authors: Patel Sandip Pravin , Pakkala Suchita , Pennell Nathan A. , Reckamp Karen L. , Lanzalone Silvana , Polli Anna , Tarazi Jamal , Robert-Vizcarrondo Francisco
Published: February 2020

Lessons Learned

This study evaluating first-line crizotinib plus pembrolizumab in patients with anaplastic lymphoma kinase (ALK)–positive advanced non-small cell lung cancer (NSCLC) was terminated early because increased availability of second-generation ALK inhibitors resulted in difficulty identifying and accruing eligible patients. In the small number of patients enrolled, elevated transaminases were the most common treatment-related toxicity. No other relevant toxicities were observed. Although no definitive conclusions could be drawn because of the small number of patients studied, the higher frequency of severe transaminase increases noted in this sample should be of concern if ALK inhibitor and PD-L1/PD-1 inhibitor combinations are tested in future studies.

Background

Previous research suggests single-agent crizotinib is efficacious for the treatment of anaplastic lymphoma kinase (ALK)–rearranged advanced non-small cell lung cancer (NSCLC).

Methods

This study evaluated the safety and preliminary antitumor activity of crizotinib plus pembrolizumab as first-line therapy in patients with ALK-rearranged NSCLC. Patients were initially treated at dose level 0 (DL0) with crizotinib 250 mg twice daily and pembrolizumab 200 mg every 3 weeks (cycle duration was 3 weeks). If a dose-limiting toxicity occurred, subsequent patients were enrolled at a lower dose level (dose level −1 [DL−1]: 3 weeks of crizotinib monotherapy 250 mg twice daily, followed by crizotinib 250 mg twice daily with the addition of pembrolizumab 200 mg every 3 weeks). The primary endpoint was dose-limiting toxicity. Antitumor activity was assessed.

Results

Nine patients were enrolled: two at DL0, then seven at DL−1. Dose-limiting toxicities occurred in four patients (grade 3 increases in alanine aminotransferase [ALT] and aspartate aminotransferase [AST] and grade 3 fatigue at DL0; grade 3 increase in ALT and grade 3 increases in both ALT and AST at DL−1).

Conclusion

The maximum tolerated dose was not determined because slow accrual resulted in early study termination.
Simulation Modeling of Competitive Strategy of Pricing
Authors: Sorokin Sergey , Varpaeva Irina , Grishina Ol'ga
Published: February 2020

Efficiency of commercial activities depends on many factors. One of the tools to study their influence is mathematical modeling. The goal of the study is to conduct a computational experiment that simulates the dynamics of the supplier’s sales volumes in a competitive environment under various initial conditions. We take into account the possibility of changing the price of products (goods), depending on changes in sales volumes. The limitation of the experiment is the conditions of the local market and the presence of the maximum value of purchasing power within it. To conduct an experiment, it is necessary to solve the following tasks: to find out the impact of sales volumes changes caused by competition on changes of the price of products (and the price of products must be calculated according to product aging factor); to consider consumers’ preferences, on which “consumer-supplier” relationships are based and to determine the relationship between the pricing models and the model of competing relations of the “supplier-suppliers” type. To achieve this goal, we employed heuristic methods of simulation modeling and the analogy method (universality). Based on simulation modeling and the method of analogies (universality), we developed a mathematical model as a part of a computational experiment. The former simulates the market price of a product and the dynamics of sales volumes of a supplier, which considers correlation between the market price for products (goods) and their aging factor, as well as consumers’ preferences and pricing model and competing relationship model. The application of the mathematical model developed by the authors allows to take into account many interrelated factors that influence the sales dynamics of market participants in real economic situations.
Digital Criminology: the Mmethod of Digital Profiling of an Unidentified Criminal's Behavior
Authors: Sukhodolov Alexander , Kaluzhina Marina , Spasennikov Boris , Kolodin Viktor
Published: February 2020

The authors examine the specific features of the digital environment to analyze contemporary approaches to the system of instruments of studying illegal actions in cyberspace. They state that law enforcement bodies should adapt key characteristics of the digital environment to the accomplishment of investigation tasks. The authors analyze the possibilities offered by digital profiling and modeling of the digital profile (portrait) of an unidentified criminal through mathematical methods of modeling and prediction in investigating and solving serial crimes, including cybercrimes. An extensive review of Russian and foreign publications is used to study the evolution of scientific ideas regarding the profiling method, which is the basis for the digital profiling of the behavioral model of an unidentified criminal in the digital environment. It is stated that none of the branches of criminal law, including criminology and criminalistics, could alone solve the interdisciplinary problem of the investigation and detection of crimes in the digital environment. The authors prove that it is necessary to integrate the knowledge of these branches and to conduct interdisciplinary research involving experts, i.e. to duly streamline the organization of those activities that together make up the investigation and detection of crimes. Based on the content of the concept «modus operandi», which lies at the heart of building an abstract model of criminal behavior, they conclude that it could be used to investigate and solve crimes in the digital environment and determine the specific features of the content of its structural elements. The comparative analysis of the contents of the key stages of profiling is used to prove the expediency of employing the whole range of logical and mathematical methods of analysis to process and analyze criminological information, which leads to the necessity of both critically reviewing them and finding ways to go beyond the traditional approaches. The authors describe the essence of the mathematical extrapolation method, which is most commonly used in criminology for the quantitative analysis of knowledge regarding objects, phenomena, processes, as well as the possibility of using it in digital profiling. As a result of this research based on the systemic approach, the authors state the objective character of links between the traditional and the digital profiling, point out the existing links and regularities, which allow them to reduce the essence of the examined phenomena to building a model through the recreation, in the process of investigation, of the mental trace pattern and then using it to find the guilty person.
Comparative Investigation of Military Metaphors in China-Russian Political Discourses
Authors: Wei Shi Chi
Published: February 2020

Political metaphor is frequently used in present-day political discourse. Nowadays, political metaphor has become one of the most lapidary, active and effective ways to express political outlooks and political influence. Complex political concepts, which are difficult to understand by everybody in the twinkling of an eye, can be easily understood after a cognitive bridge of the metaphor investigation, which helps people to see the light and understand this or that nation, the cultural inheritance, the ideology and the mode of thinking being formed at a certain historical stage of the country. In general, the article examines military metaphors, substantiates the generality of the metaphor and analyses its metaphoric unicity. Military metaphors are often used in political discourses of the both countries, which comes out as a result of comparing politics with wars. However, the fields and methods of military metaphors used in political discourse of the both countries are different, which reflects the different nationalities of the two peoples.
On Application of Prandtl-Obukhov Formula in the Numerical Model of the Turbulent Layer Depth Dynamics
Authors: Belolipetskii Victor M. , Genova Svetlana N.
Published: February 2020

A numerical simulation of the penetration of the turbulent layer in a stably stratified fluid under the action of tangential stress was performed. For the coefficient of vertical turbulent exchange, the Prandtl–Obukhov formula is used. The results of the calculations are consistent with known experimental data and calculations by other authors
A Mathematical Model Linking Ca2+-Dependent Signaling Pathway and Gene Expression Regulation in Human Skeletal Muscle
Authors: Akberdin I.R. , Vertyshev A.Yu. , Pintus S.S. , Popov D.V. , Kolpakov F.A.
Published: February 2020

The physiological adaptation to aerobic endurance exercises is provided by activation of signaling pathways in skeletal muscle cells. Training-induced activation of specific signaling pathways results in significant transcriptional responses. Despite the ongoing endeavours to experimentally investigate regulatory mechanisms and signal transduction pathways involved in the contraction-induced adaptation, quantitative contribution of certain signal molecules in expression regulation of genes responsible for intracellular response has not been studied comprehensively yet. The paper presents novel developed model linking Ca2+-dependent signaling pathway and downstream transcription regulation of early and late response genes in human skeletal muscle during exercise. Numerical analysis of the model enabled to reveal crucial steps in this signal transduction pathway for the adaptation and demonstrated the necessity of consideration of additional transcription factors regulating transcription of late response genes in order to adequately reproduce gene expression data that were taken in human vastus lateralis muscle during and after acute cycling exercise.
Review on V. V. Spivak's monography "Philosophical views by Antony Radivilovsky in the context of the Ukrainian spiritual culture of the XVII century"(Chernigiv: Scriptorium, 2018, 328 p.)
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Napadysta V. G.
Published: February 2020

The 17th century in the intellectual history of Ukraine, rich in a whole constellation of outstanding church thinkers (Petro Mohyla, Innokenty Gisel, Lazar Baranovych, Ioanikyi Galyatovskyi), is not deprived of the attention of modern scientists, whose creative searches culminated in fundamental research of historical, literary and philosophical direction.
Features of immunophenotypic finding B-cell lymphoproliferative diseases by flow cytometry
Authors: Chuksina J J , Kataeva E V , Mitina T A
Published: February 2020

Aim. To assess the information content of conventional and additional immunophenotypic markers (CD200, CD305) in the differential diagnosis B-cell lymphoproliferative diseases by flow cytometry.

Methods. An immunophenotypic study using 4-color flow cytometry was performed in 204 patients with different variants of B-cell non-Hodgkin's lymphomas. The study material included peripheral blood and bone marrow. The expression of CD45, CD19, CD20, CD22, CD79b, CD79a, CD5, CD10, CD23, FMC7, CD43, CD38, CD11c, CD103, CD25, CD 200, CD 305, light chains of immunoglobulins (kappa/lambda) using monoclonal antibodies (Becton Dickinson, USA) was evaluated. The intensity of antigen expression was assessed using mean fluorescence intensity (y. e.).

Results. Conventional FMC7-positive expression revealed only half patients with different variants of leukemization of non-Hodgkin's lymphomas, whereas atypical positive expression of CD23 was observed in patients with marginal spleen lymphoma and follicular lymphoma in 27.3 and 28.6% of cases, respectively. In mantle cell lymphoma, expression of CD200 in B-cell was detected in a significantly smaller number of observations, accompanied by a significant decrease in the average intensity of CD200 fluorescence compared to B-cell chronic lymphocytic leukemia (B-CLL) cells. The mean fluorescence intensity (MFI) of CD305 in hairy cell leukemia is significantly higher than in splenic marginal zone lymphoma (SMZL) with villous lymphocytes.

Conclusion. Different levels of the information content of some conventional markers were revealed in differential immunophenotypic diagnosis of B-cell lymphoproliferative diseases by flow cytometry; the use of additional markers CD200 and CD305 was highly informative in differential diagnostics between different variants of B-cell lymphoproliferative diseases with similar immunophenotypic and morphological characteristics of lymphoid elements.
Avaliação emancipadora: um caminho norteador para o Letramento
Authors: Donat Celita , Valério Claudia Lucia Landgraf
Published: February 2020

Este trabalho apresenta uma reflexão sobre o processo de letramento, tendo como eixo de discussão a avaliação escolar. O debate acerca do letramento é bastante frequente na área educacional e tem sido considerado importante na prática pedagógica com vistas a oportunizar uma aprendizagem significativa, respeitando a realidade dos estudantes. O letramento, na escola, também busca viabilizar a interação dos educandos com a sociedade em que vivem. O objetivo é verificar como a prática avaliativa pode contribuir para a viabilização do processo de letramento dos alunos. Para tanto busca-se o apoio para discutir a alfabetização e letramento nas concepções de Magda Soares (2003, 2004, 2006), Paulo Freire (1992, 2001) e Angela Kleiman (1995 e 2005). Para ponderar sobre avaliação buscamos fundamentar em Luckesi (2005) e Hoffmann (1993). Para relacionar os estudos realizados com a prática avaliativa da aprendizagem, conversamos com seis professoras do 2º Ano do Ensino Fundamental, da EMEF Germano Lazaretti, de Campos de Júlio/MT. Os resultados alcançados apontam na direção de que a avaliação é um componente crucial para a efetivação do letramento. Nesta ótica, os professores que pretendem exercer uma prática pedagógica voltada ao letramento de seus alunos, devem refletir sobre sua prática avaliativa.
The Importance of Architectural Monuments and Historical Buildings in Adaptation to the Modern World (the Case of Restoration of the Watermill Iraq Al-Amir)
Authors: Melnik Vlada
Published: February 2020

Architectural preservation of historical buildings is an increasingly important civilizational aspect, and dynamic environmental shaping is key to sustaining the integrity and vital functions of architectural monuments. The article looks at the revitalisation method, which, true to its literal meaning (breathing new life into something), envisages a way of sustaining the value of historical buildings by not merely restoring them but also imbuing them with new functions, thus adapting them to new demands of everyday use. A water mill in Iraq Al-Amir (Jordan) is a case study in this article.
Western Iconography’s Impact on Ethiopian Painting: European Hell in Ethiopian Churches
Authors: Kuvatova Valeria
Published: February 2020

While the Ethiopian Christian iconography relies on two major artistic traditions—Byzantine and Western European, the iconography of infernal demons was inspired specifically by Western European art. The Ethiopian tradition has developed four basic iconographic types of demons, each going back to different artistic schools, both in terms of place of origin and timing. Unexpected though evocative parallels between Ethiopian and Mozarabic depictions of Hell, Satan and other infernal beasts prompt to look for historic opportunities that could have introduced the very specific Spanish pre-Romanesque art of the 10–11th centuries to Ethiopian artists. The studies of Aragonese-Ethiopian and Portuguese- Ethiopian contacts of the 15–16th centuries support the hypothesis of Ethiopian acquaintance with illuminated Mozarabic manuscripts.
Under Oman’s Sky
Authors: Ravandi-Fadai Lana M.
Published: February 2020

Courier begins its journey of scientific discovery in one of the oldest states of the Arab world. Strategically positioned in the southeast of the Arabian peninsula and having survived a sequence of devastating wars and conflicts, by mid-twentieth century Oman was a country stuck in feudal void. Up until 1970s Oman remained one of the most closed countries in the region with scarcely any schools, hospitals, roads or radio. Now, almost 50 years later, the shining lights of Oman highways are a familiar and welcome sight for the foreigner—but to look inside this box of secrets, where epochs have blended in an unusual fashion, is no easier than before. In her notes, Lana Ravandi-Fadai tries to penetrate the daily life of Oman and see, beyond the neon lights of Muscat, the country’s capital, the live breath of the East.
Interdisciplinarity in Oriental Studies: the Results of the XIII Scholarly-Practical Conference of Young Researchers “Meliksetov Readings” (April 4, 2019, Moscow)
Authors: Volynskii Andrei
Published: February 2020

The article published here gives a review of the main results of the 13th practical conference for young scientists, called Meliksetov Readings, that took place in Moscow on April 4th 2019. This conference has been held annually since 2007 and was named after a famous Russian Sinologist, Arlen V. Meliksetov (1930–2006). Over the past decade, Meliksetov Readings have evolved into a traditional venue for young Orientalists from various scientific and educational institutions not only of Moscow, but Russia as a whole. This year, the organisers strived to emphasise the importance of inter-disciplinary approach in studying the Orient—separate countries and regions, but more globally, too, the Orient as an ontological entity.
PENINGKATAN MINAT DAN HASIL BELAJAR MATEMATIKA MATERI SEGIEMPAT DAN SEGITIGA MENGGUNAKAN MODEL PEMBELAJARAN (PAIKEM GEMBROT) PADA PESERTA DIDIK KELAS VII-D MTs NEGERI SALATIGA
Authors: Rahayuningtyas Esti , Istiqlal Muhammad
Published: February 2020

This research aimed to increase the interest mathemathics learning and student achievement of class VII-D MTs N 1 Salatiga used PAIKEM Gembrot type.the types of research was Classroom Action Research (CAR). Research was conducted minimal two cycles action. Data wa collected by questionnair, observation, interview, test and documentation.result showed an increase student interest viewed from questionnair, observation, interview  and test. Student achievement incresed to by 42,89 at pre-cycle to 85,53 in cycle I and incresed to 90,53  in cycle II. Therefore suggested to teachers use the PAIKEM Gembrot type to increase student interest and achievement.
APPLICATION OF AUTOLOGOUS PLASMA IN THE TREATMENT OF MEDICATION RELATED OSTEONECROSIS OF THE JAW
Authors: Vinogradova Natal'ya , L'vov Konstantin , Haritonova Marina , Zhirnov Aleksandr
Published: February 2020

Subject. Drug-associated jaw osteonecrosis is a serious complication that can occur in patients receiving bisphosphonate therapy for bone metastases in malignant neoplasms. The studies are due to the widespread use of bisphosphonates in patients with proven bone metastases, with myeloma, and malignant neoplasms of various locations. Due to the toxic effects of bisphosphonates on soft tissues, the healing process is sluggish, often with a relapse. The task of finding optimal methods of stimulating local regenerative processes is urgent, since the use of general-action drugs can provoke continued growth of the primary tumor. The aim of the study was to develop a method for treating patients with a diagnosis of “drug-associated jaw osteonecrosis” using autologous plasma, which will further reduce the number of relapses and increase the effectiveness of treatment. Methodology. Patients with a diagnosis of “medically associated jaw osteonecrosis” underwent sequestrectomy with boundaries determined by perfusion by laser Doppler flowmetry, an APRF clot was placed on the bottom of the bone wound, and autologous plasma was injected into the wound edges in the postoperative period. Results. The result of applying this technique in the early postoperative period was a partial discrepancy of the edges of the wound, but the absence of sections of the exposed bone in the wound. After 6–8 weeks, we observed complete healing of the postoperative wound. The number of relapses was reduced from 16 to 3 (by 57.56 %). Conclusions. The use of autologous plasma in the treatment of drug-associated osteonecrosis is the most optimal way to stimulate local regenerative processes in the absence of the possibility of using general-action drugs.
ROLE OF THE ALKALINE FACTOR IN THE DEVELOPMENT OF DENTAL CARIES
Authors: Hamzaeb Bahlul , Jafarova Ayat , Huseynova Rena , Abbasova Rumia , Yusubova Shahla , Alizade aysel , Ibrahimova Lala
Published: February 2020

Subject. This article analyzes existing theories about the prevalence and causes of dental caries, which is considered as a civilization disease.

The crucial role of endogenous factors in the risk of caries, including a pulp and dental fluid, is noted. Data are given that acids do not actively participate in the process of demineralization, which is confirmed by numerous theoretical and hypothetical points.

The role of some materials produced by dental industry based on this “pseudo-acidogenic” theory and used in the treatment of caries, as well as the false and negative consequences created by them in general, is analyzed, and adequate parallels are carried out.

The purpose of the study was the theoretical justification of the key role of acetylcholine (the cholinomimetic mediator located on the Toms fibers) in the occurrence of dental caries.

Methodology. Russian and foreign research works due to the etiology, prevalence and pathogenesis of dental caries were studied, and a comparative theoretical analysis of the available data on this issue was carried out.

Results. Based on the results of numerous studies cited in the available literature and our studies, we performed an analysis of theoretical principles and substantiated the data that the process of demineralization occurring in dental caries cannot be caused by acids. Therefore, the only and decisive factor in the origin of the demineralization process is the occurrence of the process because of alkaline substances.

Conclusions. Based on the studied references, we present the data that the most current theories of the etiopathogenesis of caries are imperfect in terms of solving the problem, which, in our opinion, requires further study of the process both of acetylcholine and the enzyme acetylcholinesterase inhibition in the local form and inside dental hard tissues.
Las parteras, patrimonio de la humanidad
Authors: Alarcón-Nivia Miguel Ángel , Sepúlveda-Agudelo Janer , Alarcón-Amaya Iván Camilo
Published: February 2020

Objetivo: presentar el origen etimológico del término partera. Describir las parteras que han hecho aportes a la obstetricia a través de la historia. Hacer una reflexión . sobre el desempeño actual de las parteras en la saludMateriales y métodos: se presentan las parteras más famosas o que hicieron aportes a la tocología o la salud pública a través de los siglos. Se describe el papel de las parteras hoy día en las diferentes regiones del mundo.Conclusión: las parteras continúan jugando un importante papel en la salud materna en varios países del mundo, dado que tienen amplia aceptación en las comunidades, reciben capacitación en buenas prácticas y pueden detectar las alteraciones tempranas del embarazo y el parto; sin embargo, en otros países este oficio se halla prácticamente en el ocaso, está reducido a zonas marginales y no cuentan con apoyo de los organismos de salud
Generał Wacław Iwaszkiewicz-Rudoszański (1871–1922) – zarys biografii
Authors: Jarno Witold
Published: February 2020

Artykuł opisuje życie generała Wacława Iwaszkiewicza-Rudoszańskiego (1871–1922). Urodził się on w Omsku, w polskiej rodzinie zesłanej na Syberię po powstaniu styczniowym. Był zawodowym oficerem armii rosyjskiej, w której służył w różnych jednostkach na Dalekim Wschodzie. Brał udział w tłumieniu tzw. powstania bokserów w Chinach oraz w wojnie rosyjsko-japońskiej 1904–1905. Po wybuchu pierwszej wojny światowej dowodził 54 pułkiem strzelców syberyjskich. W 1915 r. został awansowany na stopień generała. W armii rosyjskiej służył do 1917 r., a następnie dowodził 3 Dywizją Strzelców w I Korpusie Polskim w Rosji. Po odzyskaniu przez Polskę niepodległości zgłosił się do Wojska Polskiego i kolejno dowodził: Okręgiem Generalnym nr III Kielce, Dywizją Litewsko-Białoruską, a od marca 1919 r. był dowódcą Wojsk Polskich na Galicję Wschodnią. Dowodził wówczas odsieczą dla Lwowa, która uwolniła miasto od zagrożenia ze strony wojsk ukraińskich. W latach 1919–1920 dowodził kolejno: Frontem Galicyjskim, 6 Armią oraz Frontem Południowym. Następnie – od września 1920 r. do maja 1921 r. – był dowódcą Okręgu Generalnego numer I Warszawa. Wskutek choroby został przeniesionyw stan spoczynku i niebawem zmarł w Warszawie (pochowany został we Lwowie). Jako jeden z nielicznych był odznaczony Orderem Virtuti Militari II klasy.
La ciudadanía del hombre compasional
Authors: Rodríguez García Hernán Ferney , Olarte Fernández Alejandra Liliana , Rodríguez Benavides Iván Ramón , Dejanon Bonilla Paula Andrea
Published: February 2020

Este artículo presenta una reflexión en torno a la construcción de ciudadanía, a partir de un diálogo entre la filosofía y la literatura, con el fin de encontrar ese entre nos que las relaciona y los modos en que afectan a
los sujetos. En particular, el documento se centra en la comprensión del mal político, a través de la posibilidad de situarlo. Este ejercicio permite que se haga un juicio sobre las acciones que acometen los hombres y los marcos de interpretación que configura el poder para dominarlos.
Una vez se reconoce este dominio, se da paso a la idea del hombre compasional, como aquel que puede ejercer un tipo de ciudadanía diferente, que ataca la idea de servidumbre voluntaria y la esclavitud que se promueven. La intención central está acompañada por la caracterización de las acciones del hombre y su posibilidad de ser un perturbador, capaz de mantener la política y la democracia en continuo movimiento
¿Cómo leen los estudiantes de Negocios y Relaciones Internacionales el posconflicto en Colombia a la luz de los acuerdos de paz en Irlanda del Norte y El Salvador?
Authors: Castillo Bermúdez Ana María , Fonseca Sierra Melany Marcela , Martínez Chaparro Miguel Ángel , Ojeda Veira María Sofía , Ojeda Pérez Robert
Published: February 2020

En este trabajo se analiza cómo se desarrollaron los conflictos armados y sus procesos de paz en Irlanda del Norte, El Salvador y Colombia para evidenciar las similitudes entre estos e identificar a sus principales actores. También se tiene el objetivo de determinar si es posible que los acuerdos de paz de los primeros dos países influyan en el posconflicto en Colombia y qué se puede aprender de estos, aunque no se hayan dado en las mismas condiciones ni hayan tenido los mismos efectos. Así, se propone una tabla comparativa con variables propias de cada acuerdo, como el aspecto judicial, la reparación a las víctimas, el posacuerdo y el cumplimiento