bluuebunny/crossref_metadata_2025 huggingface dataset:
O Empreendedorismo através da Escola
Authors: Bucha Agostinho Inácio
Published: September 2017

O conceito de educação tem evoluído ao longo dos anos, passando a ser entendido não apenas como um fenómeno natural, mas sobretudo como um fenómeno social.

Esta nova escola tem de saber incorporar as transformações verificadas no meio envolvente, de modo a ser um lugar de aprendizagem e formação dos futuros profissionais. Este desempenho deve ser uma contribuição para o desenvolvimento da sociedade que encara o empreendedorismo como fazendo parte do desenvolvimento. Assim, também a escola, deve apreender a ser empreendedora no sentido de criar valor que se traduza em maior índice de qualidade de vida.
A Opção da Bélgica e da Dinamarca Face ao Artigo 5.º do Regulamento (CE) N.º 1606/2002
Authors: Marques Mário , Teixeira Cláudia
Published: September 2017

A contabilidade financeira tem como finalidade a comunicação do desempenho económico-financeiro das empresas aos seus utilizadores internos e externos. Não tendo alguns utilizadores externos, nomeadamente os investidores, acesso a outras fontes de informação, as demonstrações financeiras constituem um elemento de comunicação crucial uma vez que delas dependem algumas decisões dos agentes económicos (Veerle, 2005). O desenvolvimento das relações transnacionais e a consequente globalização dos mercados foi, ao longo dos anos, exigindo uma harmonização contabilistica impulsionada pela necessidade de proporcionar aos utilizadores uma informação mais uniforme e comparável. A harmonização contabilística europeia que se procedeu através das Directivas Comunitárias - das quais se destacam, pela sua importância na Contabilidade, a Quarta e Sétima Directivas relativas às contas anuais e consolidadas, respectivamente manifestou-se insuficiente na medida em que (a) não acompanhou o referido processo de globalização, revelando-se desactualizada quanto ao tratamento contabilístico de novas situações e (b) apresentava uma variedade de opções o que permitia alguma discricionariedade. Em meados da década de noventa, a União Europeia (UE) face à crescente importância e aceitação que o normativo do actual International Accounring Standards Board (IASB) assumia e ao acordo entre a International Organization Securities Commissions (IOSCO) e aquele organismo, começou a desenvolver um novo processo de harmonização contabilistica que visava a sua convergência com o normativo internacional. Este novo processo de harmonização inicia-se com a Comunicação da Comissão Europeia (CE) intitulada Harmonização Contabilística: uma nova estratégia relativamente à harmonização internacional COM (95) 508. Neste documento admite-se que as Directivas não respondem às exigências mais rigorosas do contexto internacional e, nomeadamente, às exigências da Securities and Exchange Commission (SEC). Assim, a UE propõe intervir no processo de harmonização internacional já iniciado pelo IASB, optando pela aproximação às suas normas ( Rodrigues e Guerreiro, 2004). Relativamente a esta matéria, também assume especial importância a Comunicação da CE COM (2000) 359 intitulada Estratégia da UE para o futuro em matéria de informações financeiras a prestar pelas empresas na qual se propõe, para as sociedades cotadas, a utilização do normativo do IASB na elaboração das contas consolidadas.
Princípios Jurídicos Ambientais e Protecção da Floresta
Authors: Gomes Carla Amado
Published: September 2017

A importância da floresta, na sua dupla dimensão de recurso económico e de bem natural, é hoje um dado social e juridicamente incontestável. Com mais de 3 milhões de hectares de área florestal no território continental, correspondente a quase 40% deste, gerando emprego para mais de 3% da população, representando relevante fonte de receita a título de exportação, a floresta constitui uma fonte de riqueza economicamente avaliável.
Pengaruh Pendidikan Kesehatan terhadap Pengetahuan dan Sikap Siswa tentang Abortus
Authors: Lukwinata Avinda Krisna , Wulandari Ning Arti
Published: September 2017

According to the National Commission for Child Protection in Indonesian at 2008 to 2010 abortions reached 2.5 million cases and 62.2% among teenagers. That caused byÂ  lackingÂ  of knowledge about abortion at teenagers. The impac of Â lacking of knowledge is bad attitude towards abortion. Method: Research design was quasy experiment. Research sample was 22 students of 1 and 2 grade SMA PGRI Srengat Â at April 22nd until May 5th, 2012, its choosed with total sampling. Data collected by observation using checklist. Analysis using Wilcoxon Signed Rank Test, with significant level â‰¤0.05. Result: The results showed that health education influence knowledge and attitude, with p value 0.001. Discussion: Health education using video and leaflet, effective to improve knowledge and attitude student about abortion. Â
Pengaruh Konseling Teknik Menyusui yang Benar terhadap Perilaku Menyusui pada Ibu Post Partum
Authors: Trisiyah Nur Faridah , Novianty Dewi
Published: September 2017

Proper breastfeeding technique is a way to give milk to the baby with the mother's position and attachment of the baby in a proper way. Counseling is done so that mothers can open minded, realizing his own mistaken of perception that associated with breastfeeding, and then expected to change or correct the incorrect perception that breastfeeding can run more smoothly.The purpose of this research was to determine the effectiveness of proper breastfeeding technique counseling to the behavior of lactating mothers in post partum day 1-14.Method: Research design was pre- experimental design with one-group pre- post test design.. The sample was 16 post-partum mothers at BPS Eny Kustiyaningsih, Amd. Keb, who was collected using total sampling. The instrument used was a checklist.Result: The result used Wilcoxon Sign Rank Test showed Ï = 0.000 (Î± = 0.05). It could be concluded that there were significant effect proper breastfeeding technique counseling to the behavior of lactating mothers in post partum day 1-14. Discussion: It was expected that the results of the research could be use as reference for further research.
Pemenuhan Kebutuhan Kasih Sayang Lansia UPT PSLU Blitar di Tulungagung
Authors: Qulub Mochamad Shofaul
Published: September 2017

Love and belonging is one of the needs in the Maslow hierarchy. Â Elders felt lonely when peoples at home busy at work and spending much time outdoor. Although every needed fulfill but elders felt lost of love and belonging from their family. The purpose of this study wasÂ  determine love and belonging needs of elders in UPT PSLU Blitar in Tuluangagung by 4 parameters there are: communication with positive feelings, respect each other a happy business, providing the opportunity or freedom, and self-control or attention. Method: Research design was descriptive design. Research sample was 44 by using purposive sampling. Data collected Â on March to May 2014 by questionnaires love and belonging needs of elders. Results: The result showed that good love and belonging fulfillment 70.5% (31 elders), the fulfillment of the needs love and belonging enough about 27.3% (12 elders), and 2.3% (1 elders) needs less fulfilled. Discuss: Based of this study are expected to provide optimal services to the elders at UPT.PSLU Blitar in Tulungagung specially for elders who have less of love and belonging fulfilled.
Hubungan Kinerja Perawat Profesional dengan Praktik Klinik Keperawatan Medikal Bedah Mahasiswa Profesi Ners di RSUD Jayapura Profinsi Papua
Authors: Padang John Toding , Medyati Novita
Published: September 2017

Clinical practice experience is a kind of learning that must be done in nursing education. Result of job performance of an organization needs measurement standard so the assessment of performance is an essential aspect for hospitals to improve nurse professional performance. Students attendance at nursing clinical practice creates function, role and responsibility in supervisory activities of heads of wards, nurses, and clinical supervisors. Purpose of this study was to assess nurse performance at Jayapura Hospital, Province of Papua in the implementation of medical surgical nursing clinical practice of nursing profession students. Method: Research study was descriptive with cross sectional design. Research sample was73 consist of 7 heads nurse, 58 nurses, and 8 clinical instructor at inpatient rooms and 49 nursing profession students. Data collected at July 2nd until 16th, 2014 by using self-administered questionaire and proceeded using software. The conclusion is availability of the study average performance of nurses was high. However according to students evaluation average performance of nurses was adequate
Aplikasi Teknik Swaddling, Side-Stomatch, Shushing, Swinging, Sucking(5S'S) terhadap Skala Nyeri dan Durasi Tangisan pada Neonatus Paska Prosedur Pengambilan Darah
Authors: Wulandari Ning Arti , Setiyorini Erni
Published: September 2017

Neonatal care at hospital involved many invasive procedures. The invasive procedures caused pain in neonates. The role of nurse is minimize the discomfort and pain for them. Negative effect when we let the pain in long time, there are immediately effect, short term effect and long term effect. 5Ss technique is useful to make baby comfortable and soothing neonates.The purpose of this study was to analyze the application of 5Ss technique to the pain and duration of crying neonates post blood sampling procedures. Method: Research design was experimental research with Quasi- Experimental design post test only with control group. The sample consisted of 50 neonates, 25 nonates in control group and 25 neonates in the experimental group, with inclusion criteria: aterm neonates, normal apgar score. Sampling was done by purposive sampling. The data was analyze by T-test. Result: The results showed that 5ss technique had effect to pain with p=0,000 and duration of crying, with p=0,011. The research recommended for calming crying neonates and reduce pain after invasive procedures and it is expected the results of this study can be considered for standart operating procedures for calming neonates.
Hubungan Perilaku Caring Perawat dengan Tingkat Kepuasan Pasien di Poli VCT RSUD Gambiran Kota Kediri Berdasarkan Teori Watson
Authors: Juwariah Titik , Joyo Nanang Bagus Witjayanto , Santosa Winanda Rizki Bagus
Published: September 2017

Caring can be seen through the attitude and action that are characteristic of the behavior. As the health care service, caring so important for patient. Patient satisfaction is indicator of quality insurance of hospital. The purpose of this study was to analyze the relationship of caring behavior of nurse with patient satisfaction in VCT clinic Gambiran hospital with Watson theory approach. Methode: Research study was analytic corelational design. Research samples was 50 of patient at VCT clinic Gambiran hospital. Data collected at July to September 2014 by using questionnaire and proceeded by Spearman Rho test. The result of this study was that caring behavior nurse correlated with patient satisfaction with p-value=0,000. According the result of this study are expected to be the input for hospitals to improve quality of service by apply minimum standart service that are caring behavior.
Aplikasi Kelas Ibu Hamil sebagai upaya Rekronstruksi Budaya "Tarak" (Tidak Makan Makan Telur, Ayam, Daging dan Ikan) pada Ibu Nifas di Kabupaten Blitar
Authors: Fanani Zaenal , Prayogi Bisepta
Published: September 2017

Indonesian peoples is a multicultural society. Each region has a distinct culture that is embraced by the trust from the previous generation ( Tommey and Alligood ,2006) . Based on a preliminary study of 20 post partum mothers, there are 17 people did not want to eat chicken dishes, meat and eggs for fear of the seams are not cured and itching . Protein is needed in the process of wound healing episiotomy and in breastfed infants, these conditions need to be an intervention . The purpose of this study was to determine the effect mother class of pregnant women to the knowledge, attitudes and behavior of post partum continence. Method: Research design was pretest and posttest nonequivalent control group with a sample of 40 people, who were divided into 20 groups and 20 controls of the treatment group. Sampling technique by using consecutive. The treatment group got mother class while the control group got health education as usual in health centers. In both groups was measured knowledge , attitudes , and behaviors " post partum continenceâ€. Results: The result of this study showed that on paired t test p = 0.000, that mean at treatment group change on knowledge before and after mother class. On control group showed that not change in knowledge with paired t test p = 0.083. In indepedentÂ  t test p = 0.000 there is a difference of knowledge between treatment groups and control groups. Paired t test p = 0.000 at the attitude shown that there is a change in attitude before and after treatment. In control group paired t test p = 0.163 indicates that there is no change in attitude. Independent t test p = 0.000 shows that there are differences in attitudes between the treatment and control groups . Chi-square test p = 0.000 on the behavior of incontinence, there are differences in the proportion of incontinence behavior between the treatment and control groups. Discussion:The research recommended mother class intervention for enhance knowledge, attitude and behavior for pregnant women of post partum incontinence culture.
Pengaruh Pendidikan Keshatan kepada Lansia terhadap Tingkat Kunjungan Posyandu Lansia
Authors: Renityas Nevy Norma , Sari Levi Tina , Wibisono Wahyu
Published: September 2017

Health education is the educational activities carried out by way of conveying a message, put faith, so that people are not only aware of, know and understand, but also willing and able to perform a suggestion related to health, for the elderly, the risk of degrading is closely related with the aging process among other circulatory disorders such as hypertension, vascular disorders, joint disorders such as osteoporosis. Nowadays, the elderly enthusiasm in Posyandu Lansia has not been going well. It was proven that there were 63 elderly in Tulungrejo did not join Posyandu. Method: The research Design was pre-experimental using one group pretest-posttest approach. The subjects of this study was 75 respondents using the total sampling technique. The sample was the elderly of Bendogerit village. Result : With a significance level of <0.0001 showed that there was an effect in before and after treatment by providing health education for the elderly to visit Posyandu Lansia. Discussion : The need for socialization is much needed in the elderly, it can also be a motivation for them to visit Posyandu Lansia.
Pengaruh Terapi Pijat Refleksi terhadap Penurunan Tekanan Darah pada Lanjut Usia dengan Hipertensi
Authors: Sari Levi Tina , Renityas Nevy Norma , Wibisono Wahyu
Published: September 2017

Elderly in the age of 60 or above is a natural process that can not be avoided where the life of man as a human being is limited by a rule of nature. As a result of the aging process, the blood vessels become stiff and affect the left ventricular wall reduce its elasticity, resulting in a progressive increase of blood pressure. The treatment of hypertension in addition to pharmacological therapy could also use non-pharmacological therapies such as reflexology massage. Â Method: The research design used in this study was pre-experimental using one group pretest-posttest approach. In this research, the researchers measured blood pressure before and after the treatment (reflexology massage). The sample of this study was 20 respondents using purposive sampling. This research used statistical t-test analysis test, because it had a scale ratio data. Result : The result of t-test showed that p <0.0001, means that there was significantly different result before and after treatment with reflexology massage on the feet with a medium timber. Discussion : It is expected that people with hypertension do the feet reflexology massage in order to taking medication because can lower systolic blood pressure.
The Efect of Breastfeeding Father to Breastmilk Production of Postpartum Mother
Authors: Sari Yeni Kartika , Rahmawati Anita
Published: September 2017

Many postpartum mothers in Indonesia can not be exclusively breastfed their babies because the breast milk could not be produced smoothly. This is due to postpartum mothers often having experience emotional disturbances which inhibit the release of oxytocin and milk. Breasfeeding father is an active role and involvement of the husband to give moral and emotional support in breastfeeding to release chemical reflexes to produce milk. This research aims to find out the effect of the application of breastfeeding-father to breast milk production. This research was one group time series design. The population of this research was all of normal deliveries of postpartum mothers in puerperal room in Mardi Waluyo Blitar Hospital. The samples selected based on writers for 30 amount people that will be measured their milk production, Â breastfeeding Â and Â the Â application Â of Â breastfeeding Â Father, Â then Â was Â given counseling about breastfeeding father and asked to implement it. The data was analized using chi-square test to figure out the difference of breastmilk production between groups applying breastfeeding father and the group did not. The results showed there was differences of breast milk production between groups that applying breastfeeding father and the group did not. So the breastfeeding father could apply the breastfeeding postpartum mothers to increase the breast milk production.
Pengaruh Penerapan Ayah ASI (Breastfeeding-Father) terhadap Produksi dan Pengeluaran ASI pada Ibu Postpartum
Authors: Nurmawati Thatit , Wulandari Nawang , Fata Ulfa Husnul
Published: September 2017

Cholesterol is needed to stabilize the double layer ( bilayer ) of phospholipids in the membrane . Cholesterol is also a precursor of steroid hormones . High cholesterol levels can cause need to watch out for deep vein thrombosis , especially when high LDL levels . Control of cholesterol in the body is absolutely necessary to regulate the levels of fat consumed each day . Carrots ( Daucus Carota ) as a source of fiber and antioxidants ( carotenoids , polyphenols and vitamin C ) that contribute to protection against cardiovascular disease . Raw carrots have tough cell walls so that less than 25 % of beta - carotene is converted to vitamin A. However, the cooking process can dissolve cellulose by breaking down the cell wall so as to facilitate absorption . The purpose of research to determine the speed difference between the cholesterol-lowering treatment with ripe raw carrots .This study used a true experimental design with control. White rat ( Rattus norvegicus ) were given a high cholesterol diet is used as experimental animals were divided into a control group and the treatment group . The treatment group were treated raw and cooked carrots . Simvastatin for the control group . Incubation 8 weeks to determine changes in cholesterol levels . Data were analyzed using parametric statistical test Kruskal Wallis test .The results showed no differences at all cholesterol-lowering treatment . Allegedly content of Î² -carotene in carrots is low . In a variety of carotenoid compounds , Î² -carotene will have lower antioxidant activity . Pectin also suffered damage to the heating activity . It is necessary to further test of the difference in the treatment of raw and cooked
Pengaruh Yoga pada Ibu Inpartu Primigravida terhadap Kemajuan Persalinan Kala I Fase Aktif
Authors: Fatmawati Diana Noor , Prastiwi Evi Dwi
Published: September 2017

The fears, anxiety, and fear both of during pregnancy, childbirth or in the face after childbirth often experienced by primigravida. Increased maternal psychological burden can cause a variety of complications that can result in the availability and quality of maternal persalianan fetus. Yoga can help mothers to overcome anxiety when faced with the birth process. This study aims to determine the progress of labor primigravida difference between the treated yoga and yoga as well as how much yoga affect the progress of labor primigravida.The research design is the design of pre experiment design with a static group comparison approach. The population was primigravida is the active phase of the first stage from April to November 2016 in BPM Nurul Aini as many as 34 people. Total sample is 17 people doing yoga and 17 people do not do yoga. The statistical test used was Wilcoxon Mann - Whitney U - Test (SPSS) and Linear Regression Test.The results of research that labor progress Kala Active Phase I primigravida given treatment yoga almost half the normal progress ie 6 hours of 8 people (47.1%) and were not given the treatment yoga accelerating progress on the 5 o'clock as many as 1 ( 5.9%). Wilcoxon Mann Whitney U Test Results in SPSS p value <0.05, it indicates that the difference between the labor progress primigravida treated yoga exercises with yoga exercises that do not. And then to know how far the influence of yoga exercises on the progress of the first stage of labor is the active phase primigravida performed linear regression test and get the value of R2 = 0.383, which means yoga exercises influence by 38.3% against the first stage of labor progress for primiravida active phase. In an effort to overcome anxiety and pain during childbirth, yoga can be disseminated to the public to be done routinely. Their yoga classes maternal health services can facilitate pregnant women to actively follow it. The participation of health workers, cadres, families and communities in the implementation of yoga classes can help implement a yoga class for pregnant women.
The Causes and Prevention of Suicide Attempts in Southern Punjab Pakistan
Authors: Shabir Ghulam , Manzoor Shafaq , Safdar Ghulam
Published: September 2017

Objective: This study is an effort to know the causes of suicide attempts and to know as how media can play a role in preventing such attempts. The literature review shows that media coverage of suicide attempt cases effects teenagers more negatively as compared to the elders. Studies also show that teenagers also copycat the suicide attempts made by the celebrities. It is not the only factor. Because the contagious suicide is not confined just to exposure of media, but attempters who personally know such people who have attempted suicide are more inclined to copy this tragic phenomenon.

Methodology: The theoretical framework of this study is based on the work of Emile Durkheim. Purposive sampling technique was used to collect data from survival of suicide attempts. (Sample Size: 50).

Results: The  result show that there are several reasons for committing suicide in southern Punjab such as parental conflict, failure in love, price hike, corruption and worse law & order situation prevailing in the country.

Implications: In light of findings of the study, it is suggested that professional help and counseling techniques can be helpful for attempters. Media can play a vital role in this regard by careful coverage of suicide attempts cases.

Objective: This study is an effort to know the causes of suicide attempts and to know as how media can play a role in preventing such attempts. The literature review shows that media coverage of suicide attempt cases effects teenagers more negatively as compared to the elders. Studies also show that teenagers also copycat the suicide attempts made by the celebrities. It is not the only factor. Because the contagious suicide is not confined just to exposure of media, but attempters who personally know such people who have attempted suicide are more inclined to copy this tragic phenomenon.

Methodology: The theoretical framework of this study is based on the work of Emile Durkheim. Purposive sampling technique was used to collect data from survival of suicide attempts. (Sample Size: 50).

Results: The  result show that there are several reasons for committing suicide in southern Punjab such as parental conflict, failure in love, price hike, corruption and worse law & order situation prevailing in the country.

Implications: In light of findings of the study, it is suggested that professional help and counseling techniques can be helpful for attempters. Media can play a vital role in this regard by careful coverage of suicide attempts cases.
Impact of Loneliness and Locus of Control on Depression of Elderly
Authors: Khurram Bukhari Fatima , Bin Mahamood Yahaya , Binti Mat Saad Zarina
Published: September 2017

The present study will explore the impact of loneliness and locus of control on depression of elderly with the moderating role of religiosity in Punjab, Pakistan. The sample will be consisted on 800 individuals, 400 individuals from male population and 400 from female population of Punjab. The male population will be further divided on the basis of age, family size, marital status, education and socioeconomic status. Similarly female population will also be further divided on the basis of age, family size, marital status, education and socioeconomic status. Geriatric depression scale will be used to measure the level of depression in Elderly, University of California Los Angles loneliness scale will be used to measure loneliness. Levenson multidimensional Locus of control scale will be used to check the level of locus of control, Religiosity will act as a moderator and will be checked by using religiosity scale. Result of the study will be revealed by using Structural equation modeling technique with the help of Partial Least Square software.
On the Stability of Digital Position Control with Viscous Damping and Coulomb Friction
Authors: Budai Csaba , Kovács L. László
Published: September 2017

In this paper, we investigate the combined effect of viscous damping and Coulomb friction on sampled-data mechanical systems. In these systems, instability can occur due the sampling of the applied discrete-time controller which is compensated by the two different physical dissipation effects. In order to investigate the interplay between these, we focus on how the stable domain of operation is extended by the dry friction compared to viscous damping. We also show that dry friction causes concave envelope vibrations in this extended region. The analytical results, presented in the form of stability charts, are verified by a detailed set of simulations at different representative control parameter values.
Estimation of the Performance Improvement of Pre-Amplified PAM4 Systems When Using Multi-Section Semiconductor Optical Amplifiers
Authors: Ó Dúill Seán , Landais Pascal , Barry Liam
Published: September 2017

Multi-section semiconductor optical amplifiers (SOA) have been shown to have superior noise and linearity performance compared with single section SOAs. We show how to create a simplified numerical model for multi-section SOAs that is suitable for optical communication system simulations and use that model to investigate the amplification performance of 56 Gbit/s four-level pulse amplitude modulation signals. We find that a multi-section SOA could provide an improvement in input power dynamic range exceeding 3 dB compared to a single section SOA that has the same unsaturated gain.
The NARX Model-Based System Identification on Nonlinear, Rotor-Bearing Systems
Authors: Ma Ying , Liu Haopeng , Zhu Yunpeng , Wang Fei , Luo Zhong
Published: September 2017

In practice, it is usually difficult to obtain the physical model of nonlinear, rotor-bearing systems due to uncertain nonlinearities. In order to solve this issue to conduct the analysis and design of nonlinear, rotor-bearing systems, in this study, a data driven NARX (Nonlinear Auto-Regressive with exogenous inputs) model is identified. Due to the lack of the random input signal which is required in the identification of a system′s NARX model, for nonlinear, rotor-bearing systems, a new multi-harmonic input based model identification approach is introduced. Moreover, the identification results of NARX models on the nonlinear, rotor-bearing systems are validated under different conditions (such as: low speed, critical speed, and over critical speed), illustrating the applicability of the proposed approach. Finally, an experimental test is conducted to identify the NARX model of the nonlinear rotor test rig, showing that the NARX model can be used to reproduce the characteristics of the underlying system accurately, which provides a reliable model for dynamic analysis, control, and fault diagnosis of the nonlinear, rotor-bearing system.
Reduced Cytokine Release in Ex Vivo Response to Cilengitide and Cetuximab Is a Marker for Improved Survival of Head and Neck Cancer Patients
Authors: Cedra Susan , Wiegand Susanne , Kolb Marlen , Dietz Andreas , Wichmann Gunnar
Published: September 2017

Targeting of αVβ3 and αVβ5 integrins by cilengitide may reduce growth of solid tumors including head and neck squamous cell carcinoma (HNSCC). Preclinical investigations suggest increased activity of cilengitide in combination with other treatment modalities. The only published trial in HNSCC (ADVANTAGE) investigated cisplatin, 5-fluorouracil, and cetuximab (PFE) without or with once (PFE+CIL1W) or twice weekly cilengitide (PFE+CIL2W) in recurrent/metastatic HNSCC. ADVANTAGE showed good tolerability of the cilengitide arms and even lower adverse events (AEs) compared to PFE but not the benefit in overall survival expected based on preclinical data. As we found in the FLAVINO assay, a short-time ex vivo assay for prediction of chemosensitivity, only a subgroup of HNSCC had an increased suppressive effect of cilengitide containing combination therapies on colony formation of epithelial cells (CFec) and release of pro-angiogenetic and pro-inflammatory cytokines, whereas other HNSCC failed to respond. Response to αVβ3 and αVβ5 integrin targeting by cilengitide classifies HNSCC regarding outcome. We present FLAVINO data arguing for further development of cilengitide plus cetuximab in treatment of a subgroup of HNSCC potentially identified by the FLAVINO assay using a set of biomarkers for response evaluation.
Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes
Authors: Zeka Keti , Ruparelia Ketan , Arroo Randolph , Budriesi Roberta , Micucci Matteo
Published: September 2017

The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future therapies, we propose that molecular mechanisms should be investigated. Once the aetiology of the metabolic syndrome is clear, a nutritional intervention should be assessed. Here we focus on the protective effects of some dietary flavonoids, and their metabolites. Further studies may also pave the way for development of novel drug candidates.
Wire Structure Heat Exchangers—New Designs for Efficient Heat Transfer
Authors: Fugmann Hannes , Laurenz Eric , Schnabel Lena
Published: September 2017

Enhancing the heat transfer mechanism by increasing the heat exchanger surface area is a standard way to overcome low heat transfer on the gas side of heat exchangers. Different geometrical shapes, for example, plain, wavy, or interrupted fin geometries for plate-fin or tube-fin heat exchangers, are used for this task. Wire structures with dimensions in the submillimeter range are already used in regenerators for their heat capacity, but are rarely used in recuperators as heat transfer enhancers. New textile developments enable the fabrication of adapted structures with irregular grid sizes, and purpose-built for heat exchanger application. These wire structures allow for enlarging the heat transfer surface area, decreasing material utilization, and enabling flexibility of different geometrical dimensions. Possibilities for manufacturing and design selection are studied in the project, EffiMet, and thereafter at Fraunhofer ISE for the implementation of highly efficient heat exchanger geometries based on wire structures.
Environmental Risks and Uncertainty with Respect to the Utilization of Recycled Rolling Stocks
Authors: Serrano Luca , Lewandrowski Tomasz , Liu Ping , Kaewunruen Sakdirat
Published: September 2017

The railway industry is one of the most important sectors driving growth of regional economies worldwide. The industry has long dealt with both infrastructure and rolling stock. Many of these have reached the end of their lives. This paper highlights the rail policy for managing end-of-life rail vehicles. Initially when manufacturing rolling stock, different materials are considered in design and manufacture such as steel, aluminum, copper, polymers, glass. Based on the high economic and carbon costs of these materials, it is worthwhile to reuse or recycle them after their end-of-life cycle. In this study, three types of trains have been evaluated for comparison: freight, passenger and high speed. The material breakdowns from rail vehicles are evaluated for feasible applications in terms of reusing or recycling train components. We consider every material, taking into account the process of production, remaining life, advantages, disadvantages and potential threats derived from using such residual materials. The key aspects are risks and uncertainty associated with chemical and physical processes, corrosion and its varieties, oxidation, impact on the environment, release of toxicity, and pollution to the soil. These negative effects can indeed harm people, children, and assets in the vicinity. This paper therefore highlights the possibilities of recycling residual materials derived from rolling stock waste and any danger to the environment and the community, so that hazardous waste management can be put in place at the right time. Such insight will better shape sustainability policy for rolling stock procurement in the future.
Time-Dependent Production of the Bioactive Peptides Endolides A and B and the Polyketide Mariline A from the Sponge-Derived Fungus Stachylidium bicolor 293K04
Authors: Almeida Celso , Bills Gerald , González-Menéndez Víctor , Martin Jesús , Tormo José R. , Genilloud Olga
Published: September 2017

Previous investigations of the sponge-derived fungus Stachylidium bicolor (S. bicolor) 293K04 led to the isolation of the biosynthetically unusual polyketides marilines A-C and the bioactive tetrapeptides endolides A-B, identified as potential neuropathic drug leads. Furthermore, prior extended solid cultivation of S. bicolor 293K04 for 60 days resulted in a significant increase of polyketide yield, and the isolation of seven new polyketides. Due to the interest in endolide activity, unusual biosynthetic diversity, and the late stage polyketide production, we studied the cultivation conditions for determining the production time distribution and yields of these secondary metabolites. Results indicated a first production phase of secondary metabolite dominated by peptides, after 21–23 days. Polyketide mariline A1/A2 only started at day 35 of growth, an unusually late period for secondary metabolite expression. This unusual bimodal sequential expression of different families of secondary metabolites suggests value in exploring extended cultivation times to identify novel bioactive fungal compounds.
Knots in Relativistic Transverse Stratified Jets
Authors: Meliani Zakaria , Hervet Olivier
Published: September 2017

We investigate the plasmoid knot formation in stratified relativistic jet by means of relativistic magneto-hydrodynamics simulations. Indeed, astrophysical jets in active galactic nuclei (AGN) seem to be transversely stratified, with a fast inner jet and a slower outer jet. It is likely that the launching mechanism for each component is different. On the other hand, the steady and moving knots’ properties are observed along these jets. With the proposed model, we were able to link the different types of observed knot in various radio loud AGN with specific stratified jet characteristics. We showed that the increase energy flux at the outer edge of the jet induces a steady knot near the core and a moving knot at a greater distance.
Active Transportation on a Complete Street: Perceived and Audited Walkability Correlates
Authors: Jensen Wyatt , Brown Barbara , Smith Ken , Brewer Simon , Amburgey Jonathan , McIff Brett
Published: September 2017

Few studies of walkability include both perceived and audited walkability measures. We examined perceived walkability (Neighborhood Environment Walkability Scale—Abbreviated, NEWS-A) and audited walkability (Irvine–Minnesota Inventory, IMI) measures for residents living within 2 km of a “complete street”—one renovated with light rail, bike lanes, and sidewalks. For perceived walkability, we found some differences but substantial similarity between our final scales and those in a prior published confirmatory factor analysis. Perceived walkability, in interaction with distance, was related to complete street active transportation. Residents were likely to have active transportation on the street when they lived nearby and perceived good aesthetics, crime safety, and traffic safety. Audited walkability, analyzed with decision trees, showed three general clusters of walkability areas, with 12 specific subtypes. A subset of walkability items (n = 11), including sidewalks, zebra-striped crosswalks, decorative sidewalks, pedestrian signals, and blank walls combined to cluster street segments. The 12 subtypes yielded 81% correct classification of residents’ active transportation. Both perceived and audited walkability were important predictors of active transportation. For audited walkability, we recommend more exploration of decision tree approaches, given their predictive utility and ease of translation into walkability interventions.
Changes in Daily Steps and Body Mass Index and Waist to Height Ratio during Four Year Follow-Up in Adults: Cardiovascular Risk in Young Finns Study
Authors: Salin Kasper , Hirvensalo Mirja , Magnussen Costan , Telama Risto , Hutri-Kähönen Nina , Viikari Jorma , Raitakari Olli , Tammelin Tuija
Published: September 2017

Aims: Over the study years, there was a significant increase in body mass index (BMI) and waist-to-height ratio (WtHR) in middle aged Finnish adults. Methods: Data were obtained from 1033 Finnish adults from the Cardiovascular Risk in Young Finns Study in 2007 and 2011. Cohort study participants wore an Omron Walking Style One (HJ-152R-E) pedometer for five days and were grouped into those who increased, maintained and decreased their steps between 2007 and 2011. Paired samples t-test was used to compare body mass index (BMI) and waist-to-height ratio (WtHR) change values between the change groups in study years. Results: Among study population BMI and WtHR increase between study years was statistically significant (p < 0.001). Only those, who increased their total steps for at least 2000 steps, maintained their BMI in the same level, while people who decreased or maintained their total steps in the same level, BMI and WtHR increased during four years follow-up. Conclusions: This data suggests that increasing steps in middle age is associated with maintaining BMI at the same level.
Towards an Affordance-Based Ad-Hoc Suitability Network for Indoor Manufacturing Transportation Processes
Authors: Scholz Johannes , Schabus Stefan
Published: September 2017

In manufacturing companies, productivity and efficiency are the main priorities, besides an emphasis on quality issues. The outcome of this research contributes to increasing production quality and efficiency in manufacturing. The article deals with indoor manufacturing environments and the transportation processes of production assets—referred to as smart transportation. The authors modelled the objects present in the indoor manufacturing environment with ontologies including their affordances and spatial suitability. To support flexible production and dynamic transportation processes have to be tailored towards the ‘needs’ of the production asset. Hence, the authors propose an approach utilizing an ad-hoc suitability network to support the “optimal” path computation for transportation processes. The objective is to generate a graph for routing purposes for each individual production asset, with respect to the affordances of the indoor space for each production asset, and measurements of a sensor network. The generation of the graph follows an ad-hoc strategy, in two ways. First, the indoor navigation graph is created exactly when a path needs to be found—when a production asset shall be transported to the next manufacturing step. Secondly, the transportation necessities of each production asset, as well as any disturbances present in the environment, are taken into account at the time of the path calculation. The novelty of this approach is that the development of the navigation graph—including the weights—is done with affordances, which are based on an ontology. To realize the approach, the authors developed a linked data approach based on manufacturing data and on an application ontology, linking the indoor manufacturing environment and a graph-based network. The linked data approach is finally implemented as a spatial graph database containing walkable corridors, production equipment, assets and a sensor network. The results show the optimal path for transportation processes with respect to affordances of the indoor manufacturing environments. An evaluation of the computational complexity shows that the affordance-based ad-hoc graphs are thinner and thus reduce the computational complexity of shortest path calculations. Hence, we conclude that an affordance-based approach can help to decrease computational efforts for calculating “optimal” paths for transportation purposes.
Enhancing Face Identification Using Local Binary Patterns and K-Nearest Neighbors
Authors: Kambi Beli Idelette , Guo Chunsheng
Published: September 2017

The human face plays an important role in our social interaction, conveying people’s identity. Using the human face as a key to security, biometric passwords technology has received significant attention in the past several years due to its potential for a wide variety of applications. Faces can have many variations in appearance (aging, facial expression, illumination, inaccurate alignment and pose) which continue to cause poor ability to recognize identity. The purpose of our research work is to provide an approach that contributes to resolve face identification issues with large variations of parameters such as pose, illumination, and expression. For provable outcomes, we combined two algorithms: (a) robustness local binary pattern (LBP), used for facial feature extractions; (b) k-nearest neighbor (K-NN) for image classifications. Our experiment has been conducted on the CMU PIE (Carnegie Mellon University Pose, Illumination, and Expression) face database and the LFW (Labeled Faces in the Wild) dataset. The proposed identification system shows higher performance, and also provides successful face similarity measures focus on feature extractions.
A Piezoresponse Force Microscopy Study of CaxBa1−xNb2O6 Single Crystals
Authors: Shvartsman Vladimir , Gobeljic Danka , Dec Jan , Lupascu Doru
Published: September 2017

Polar structures of CaxBa1−xNb2O6 (CBN100x) single crystals were investigated using piezoresponse force microscopy. Increasing Ca content results in decreasing domain size and enhancement of the polar disorder. For the composition with x = 0.32 the characteristic domain size is similar to that reported for relaxor Sr0.61Ba0.39Nb2O6 (SBN61). However, decay of an artificial macroscopic domain in CBN32 takes place below the macroscopic transition temperature, contrary to SBN61, where random fields stabilize it above the transition temperature. We can conclude that CBN with 0.26 ≤ x ≤ 0.32 does not display classical relaxor behavior and might be considered as a disordered ferroelectric.
Magnetic Force Microscopy of Nanostructured Co/Pt Multilayer Films with Perpendicular Magnetization
Authors: Ermolaeva O. , Gusev N. , Skorohodov E. , Petrov Yu. , Sapozhnikov M. , Mironov V.
Published: September 2017

We present the results of magnetic force microscopy investigations of domain structures in multilayer [Co (0.5 nm)/Pt (1 nm)]5 thin film structures (denoted hereafter as Co/Pt) modified by additional Co capping layers and by ion irradiation. It is demonstrated that a Co capping layer essentially changes the domain structure and decreases the threshold of magnetization reversal, due to the formation of noncollinear magnetization in Co/Pt. It is shown that local irradiation with a focused He+ ion beam enables the formation of regions with decreased easy-axis anisotropy (magnetic bubbles) that have the inverse magnetization direction in the demagnetized state of Co/Pt. The experimental results demonstrate that the magnetic bubbles can be switched using a probe of a magnetic force microscope. The possible application of these effects for the development of magnetic logic and data storage systems is discussed.
Metamaterial Waveguide Devices for Integrated Optics
Authors: Amemiya Tomohiro , Kanazawa Toru , Yamasaki Satoshi , Arai Shigehisa
Published: September 2017

We show the feasibility of controlling the magnetic permeability of optical semiconductor devices on InP-based photonic integration platforms. We have achieved the permeability control of GaInAsP/InP semiconductor waveguides by combining the waveguide with a metamaterial consisting of gate-controlled split ring resonators. The split-ring resonators interact magnetically with light travelling in the waveguide and move the effective relative permeability of the waveguide away from 1 at optical frequencies. The variation in permeability can be controlled with the gate voltage. Using this variable-permeability waveguide, we have built an optical modulator consisting of a GaInAsP/InP Mach–Zehnder interferometer for use at an optical communication wavelength of 1.55 μm. The device changes the permeability of its waveguide arm with controlling gate voltage, thereby varying the refractive index of the arm to modulate the intensity of light. For the study of variable-permeability waveguide devices, we also propose a method of extracting separately the permittivity and permeability values of devices from the experimental data of light transmission. Adjusting the permeability of optical semiconductors to the needs of device designers will open the promising field of ‘permeability engineering’. Permeability engineering will facilitate the manipulation of light and the management of photons, thereby contributing to the development of novel devices with sophisticated functions for photonic integration.