bluuebunny/crossref_metadata_2025 huggingface dataset:
Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages
Authors: Starace Michela , Granger Corinne , Carpanese Miriam Anna , Alessandrini Aurora , Bruni Francesca , Piraccini Bianca Maria
Published: August 2022

Objectives

The objective of our study is the review of the literature on the efficacy and safety of a novel water‐soluble nail strengthened (WSNS) containing hyaluronic acid and Pistacia lentiscus used for the improvement of nail plate diseases.

Materials and Methods

We conducted literature research on PubMed/MEDLINE to identify all the studies reporting the use of hyaluronic acid and P. lentiscus in the improvements of nail alterations.

Results

We found two reports and two posters published in the literature, accounting for 96 patients treated with WSNS containing P. lentiscus and hyaluronic acid. The 83 patients were affected by brittle nails and 13 patients by onychomycosis.

Conclusions

This review demonstrates that the daily application of this new product containing P. lentiscus and hyaluronic acid can be used as a cosmetic adjuvant for improving common nail diseases such as nail fragility and onychomycosis, with significant results on nail quality and appearance. Patients did not report any adverse events and its ease of application and cosmetic qualities contribute to the great compliance to treatment.
Satisfaction with dental appearance in two cohorts of 75‐year‐olds examined in 2007 and 2017: A repeated cross‐sectional study
Authors: Johansson Anders , Omar Ridwaan , Carlsson Gunnar E. , Sannevik Josefin , Mastrovito Berit , Johansson Ann‐Katrin
Published: August 2022

Background

Satisfaction with dental appearance plays an important role in the self‐esteem and psychological well‐being of the elderly, the significance of which the attending dentist may not always be fully cognisant of.

Objectives

To assess the level of satisfaction with dental appearance, its associated factors and temporal changes in two cohorts of 75‐year‐old Swedes born 10 years apart.

Methods

In 2007, a questionnaire was mailed to all those living in Örebro and Östergötland counties, Sweden, who were born in 1932 (n = 5195), and in 2017 to all born in 1942 (n = 7204). The evaluation was carried out with a global question ‘Are you satisfied with the appearance of your teeth?’, and four attitude‐related statements about dental appearance.

Results

About 80% in both cohorts were ‘very satisfied’ or ‘to large extent satisfied’ with their dental appearance. The 1932 cohort was significantly more concerned about their dental appearance than the 1942 cohort, and women were generally also significantly more concerned than men. In the regression analysis, ‘very satisfied’ with dental appearance was predicted by good chewing efficiency, having complete dentures, no impact from Oral Impacts on Daily Performance, disagreement that ‘minor esthetic imperfections of the teeth have no importance, only they should function well’, better perceived general health than same‐aged peers and belonging to the 1932 cohort.

Conclusion

Satisfaction with dental appearance among 75‐year‐olds was generally high, with attitudes varying by gender and temporally. Women and the earlier‐born generation (1932) were more concerned about dental appearance than men and the later‐born generation (1942), respectively.
Complex population history affects admixture analyses in nine‐spined sticklebacks
Authors: Feng Xueyun , Merilä Juha , Löytynoja Ari
Published: August 2022

Introgressive hybridization is an important process in evolution but challenging to identify, undermining the efforts to understand its role and significance. On the contrary, many analytical methods assume direct descent from a single common ancestor, and admixture among populations can violate their assumptions and lead to seriously biased results. A detailed analysis of 888 whole‐genome sequences of nine‐spined sticklebacks (Pungitius pungitius) revealed a complex pattern of population ancestry involving multiple waves of gene flow and introgression across northern Europe. The two recognized lineages were found to have drastically different histories, and their secondary contact zone was wider than anticipated, displaying a smooth gradient of foreign ancestry with some curious deviations from the expected pattern. Interestingly, the freshwater isolates provided peeks into the past and helped to understand the intermediate states of evolutionary processes. Our analyses and findings paint a detailed picture of the complex colonization history of northern Europe and provide backdrop against which introgression and its role in evolution can be investigated. However, they also expose the challenges in analyses of admixed populations and demonstrate how hidden admixture and colonization history misleads the estimation of admixture proportions and population split times.
Dark nighttime interventions and sleep quality in intensive care unit patients: A systematic review and meta‐analysis
Authors: da Silva Higa Karina Thalita , Böhme Fernanda Aparecida Ferraro , Paschoa Simone , Conte Ana Cláudia Rodrigues , Santos Vinicius Batista , Avelar Ariane Ferreira Machado
Published: August 2022

Background

Sleep disturbances resulting from adverse clinical and environmental conditions are associated with unfavourable outcomes in critically ill patients.

Aim

To collect evidence on the effect of dark nighttime interventions on sleep quality and daytime sleepiness in intensive care unit (ICU) patients.

Study Design

The study followed the Preferred Reporting Items for Systematic reviews and Meta‐Analyses recommendations. This is a systematic review and meta‐analysis of experimental and quasi‐experimental studies, developed with adult patients admitted to ICUs and submitted to measures such as environmental brightness reduction, eye mask or blue light‐blocking glass use at night. Outcomes were subjective or objective sleep quality and excessive daytime sleepiness. Search was carried out in the PubMed/MEDLINE, Cochrane Library, Embase, Virtual Health Library, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Scopus databases, using grey literature. Covidence software, Cochrane tools and Grading of Recommendations Assessment, Development and Evaluation were used, and a meta‐analysis was performed using RevMan software.

Results

Thirteen articles were included in the systematic review and seven studies were included in the meta‐analysis. There were 3 trials with 175 participants regarding lighting reduction and environmental noise control versus the usual routine, 2 of these trials, with 96 patients, were compiled in meta‐analysis in which it was observed a significant statistical improvement in subjective sleep quality, mean difference (MD) of 11.89 points (0–100); 95% confidence interval (CI) 8.0–15.76, evidence set with moderate certainty, as well as this same intervention, reduced daytime sleepiness in 2 trials, 135 participants (standardized MD −0.63; 95% CI −0.98 to −0.28), with low certainty evidence. Eye masks versus usual routine, 2 trials, 126 participants, improved subjective sleep quality (MD of 10 points; 95% CI 7.97–12.03), with moderate certainty of evidence. Eye mask use combined with other therapies versus usual routine, 5 trials, 204 participants, improved subjective sleep quality in all studies, with low certainty of evidence. Objective sleep assessment was not improved with these interventions.

Conclusions

This review shows some benefits of nighttime interventions on subjective sleep quality and excessive sleepiness, however, there is an urgent need to conduct better and more robust studies in this field.

Relevance to Clinical Practice

applying measures such as lighting reduction and eye mask use significantly improves sleep quality.
Supported self‐management in temporomandibular disorders: A systematic review of behavioural components
Authors: Palmer Julia , Penlington Chris , Durham Justin
Published: August 2022

Aim

The aim of this narrative systematic review is to use the behaviour change techniques taxonomy to identify the most frequently used behaviour change techniques in published supported self‐management (SSM) programmes to manage temporomandibular disorder (TMD) in adult patients.

Materials and methods

Electronic database and manual searches were undertaken for randomized controlled trials assessing a SSM intervention for TMD. A definition of SSM was constructed from multiple sources and used as a basis for eligibility criteria. The relevant behaviour change technique (BCT) used within each SSM intervention was identified according to the definitions of the behaviour change taxonomy (version1).

Results

Twenty randomized controlled trials were identified as eligible for inclusion in this systematic review. No study tested multiple SSM programmes or tested SSM against no treatment or placebo. There was a wide variety in the number and types of BCTs used within the SSM interventions.

Conclusions

Evidence regarding SSM is limited with significant differences identified between SSM programmes. Further research is required to test differing SSM programmes and to test the intervention against no treatment. Improved reporting of methodologies and consensus on the minimum required components to be used within a SSM intervention would improve comparison between studies.
Efficacy and safety of valbenazine in Japanese patients with tardive dyskinesia: A multicenter, randomized, double‐blind, placebo‐controlled study (J‐KINECT)
Authors: Horiguchi Jun , Watanabe Koichiro , Kondo Kazuoki , Iwatake Atsushi , Sakamoto Hajime , Susuta Yutaka , Masui Hideaki , Watanabe Yumi
Published: August 2022

Aim

Valbenazine is approved in the US for treatment of tardive dyskinesia (TD); however, efficacy/safety data in Asian populations are lacking. We assessed the efficacy/safety of valbenazine in Japanese patients.

Methods

This phase II/III, multicenter, randomized, double‐blind, placebo‐controlled study (NCT03176771) included adult psychiatric patients with TD, who were randomly allocated to receive placebo or valbenazine (once‐daily 40‐ or 80‐mg) for a 6‐week, double‐blind period, after which the placebo group was switched to valbenazine for a 42‐week extension. The primary endpoint was change from baseline in Abnormal Involuntary Movement Scale (AIMS) total score at Week 6; clinical global impression of improvement of TD (CGI‐TD) was also assessed.

Results

Of 256 patients, 86, 85, and 85 were allocated to the 40‐mg valbenazine, 80‐mg valbenazine, and placebo groups, respectively. Least‐squares mean (95% confidence interval) change from baseline in AIMS score at Week 6 was −2.3 (−3.0 to −1.7) in the valbenazine 40‐mg group, −3.7 (−4.4 to −3.0) in the 80‐mg group, and −0.1 (−0.8 to 0.5) in the placebo group; both treatment groups showed statistically significant improvements vs. placebo. Patients switched to valbenazine at Week 6 showed similar improvements in AIMS scores, which were maintained to Week 48. Improvements in CGI‐TD scores were observed for both treatment groups vs. placebo. Incidence of adverse events was highest in the 80‐mg group; common events included nasopharyngitis, somnolence, schizophrenia worsening, hypersalivation, insomnia, and tremor.

Conclusion

The efficacy/safety profile of valbenazine was similar to that of previous clinical trials, supporting its use for TD treatment in Japanese patients.
Studies of Diaporthe species causing hazelnut canker disease in Beijing, China, with two new species described
Authors: Bai Yukun , Pan Meng , Gao Hong , Lin Lu , Tian Chengming , Fan Xinlei
Published: August 2022

Hazelnut (Corylus heterophylla) is a common tree species grown as a crop with high economic value. However, many diseases caused by Diaporthe greatly affect the health of hazelnuts. In this study, 35 isolates were obtained from hazelnuts with typical canker symptoms in Beijing, China. Four species of Diaporthe were identified through multilocus phylogenetic (ITS, cal, his3, tef1‐α and tub2) and morphological analyses, including two new species (Diaporthe donglingensis and D. huairouensis) and two known species (D. corylicola and D. eres). D. donglingensis, D. eres and D. huairouensis were confirmed as the causal agents of canker of hazelnut by pathogenicity tests conducted on 2‐year‐old plants in the greenhouse. The current study contributes to the identification of species causing canker disease of hazelnut and provides useful information for effective disease management.
Lobbying, political competition and the welfare effect of campaign contribution tax
Authors: Le Thanh , Yalcin Erkan
Published: August 2022

This paper develops a probabilistic voting model in which a single lobby group commits campaign contributions to parties, contingent on the policy position the party adopts. Parties may have different propensities for diverting campaign funds towards rents. We show that a party that skims more from contributions mobilises fewer uninformed voters but places more value on receiving greater contributions. Further, the contributions and vote share of the party increases with the distance between the lobby's preferred policy and the median voter's ideal policy. Finally, we show that the equilibrium policy is between the median voter's ideal point and the lobby's preferred policy. Such an equilibrium policy does not maximise the aggregate social welfare due to the distortionary nature of lobbying. However, when an appropriate contribution tax is introduced to limit this distortion, social welfare will be maximised.
Assessing Time-Varying Lumbar Flexion–Extension Kinematics Using Automated Pose Estimation
Authors: Goncharow Paul N. , Beaudette Shawn M.
Published: August 2022

The purpose of this research was to evaluate the algorithm DeepLabCut (DLC) against a 3D motion capture system (Vicon Motion Systems Ltd) in the analysis of lumbar and elbow flexion–extension movements. Data were acquired concurrently and tracked using DLC and Vicon. A novel DLC model was trained using video data derived from a subset of participants (training group). Accuracy and precision were assessed using data derived from the training group as well as in a new set of participants (testing group). Two-way analysis of variance were used to detect significant differences between the training and testing sets, capture methods (Vicon vs DLC), as well as potential higher order interaction effect between these independent variables in the estimation of flexion–extension angles and variability. No significant differences were observed in any planar angles, nor were any higher order interactions observed between each motion capture modality with the training versus testing data sets. Bland–Altman plots were used to depict the mean bias and level of agreement between DLC and Vicon for both training and testing data sets. This research suggests that DLC-derived planar kinematics of both the elbow and lumbar spine are of acceptable accuracy and precision when compared with conventional laboratory gold standards (Vicon).
An Efficient Variable Neighborhood Search for Generalized Regenerator Location Problems
Authors: Mrkela Lazar
Published: August 2022

Optical networks are one of the fastest data communication networks, which use optical fiber cables for transmitting data in the form of light pulses between sender and receiver nodes. As the quality of optical signal deteriorates when increasing the distance among terminal nodes, expensive electronic devices (regenerators) must be deployed in the network to recover the signal quality. The objective of Generalized Regenerator Location Problem (GRLP) is to minimize the number of installed regenerators, while weighted variant (WGRLP) assumes different installation costs (weights) of potential regenerator locations and minimizes the sum of regenerator installation costs. In this study, an improved variant of Basic Variable Neighborhood Search (iBVNS) was developed as a metaheuristic solution approach to both GRLP and WGRLP. Computational results provided by the proposed iBVNS on all available data sets from the literature are compared with the results of existing solution methods for GRLP and WGRLP. The obtained results show that the proposed iBVNS quickly reaches optimal or near-optimal solutions and in many cases improves upper bounds provided by exact method. In addition, the conducted non-parametric statistical tests indicate that iBVNS outperforms all heuristic approaches proposed earlier in the literature for the considered problems.
An Efficient Revocable Identity-Based Encryption with Equality Test Scheme for the Wireless Body Area Network
Authors: Tsai Tung-Tso , Lin Han-Yu , Chang Hsiao-Chieh
Published: August 2022

With the rapid development and popularization of cloud computing, people are willing to upload their own data to the cloud to enjoy the services. However, some personal and private data are not suitable for uploading directly to the cloud. Therefore, these data must be encrypted before uploading to the cloud to ensure the confidentiality. To achieve the confidentiality of data and enjoy cloud services, a notion of identity-based encryption with equality test (IBEET) was proposed. Using IBEET, two ciphertexts encrypted under different public keys can be tested to confirm whether they contain the same plaintext. The equality test can be applied to the wireless body area network system in which the cloud can utilize ciphertexts from patients and medical institutions to perform equality tests to determine whether which patient’s status is abnormal. Indeed, revoking illegal or expired users on any cryptosystem is an important issue. To the best of our knowledge, there is little research on the design mechanism of user revocation in the IBEET. In this paper, we propose a novel notion of revocable identity-based encryption with an equality test, called RIBEET. Based on the notion, we present the first RIBEET scheme. Meanwhile, the proposed scheme will be proven to be secure under the bilinear Diffie-Hellman (BDH) assumption.
Clinical Application Value of Group‐Sharing Nursing Management Based on Case Analysis
Authors: Mei Jing , Wu Yifan , Hu Jie , Li Min
Published: August 2022

The purpose of this study was to explore the clinical application value of group sharing nursing management based on a case analysis. The archive data of 90 nurses in 15 nursing units of our hospital were analyzed retrospectively. A total of 90 nurses from 15 nursing units in our hospital were retrospectively analyzed: the nurses before the implementation of the “case study‐based group shared care management” program from January 2019 to January 2020 were set up as the control group, and the same nurses after the implementation of the program from January 2020 to January 2021 were set up as the study group. The nurses in the study group and the control group corresponded to 9759 and 8973 clinical inpatients, respectively. The overall incidence of medication‐related, falling, tube‐related, exam‐related, and other types of adverse events was lower in the study group (0.52% vs. 1.29%) than those in the control group (P < 0.05); the overall nursing adverse event rating was lower in the study group than that in the control group (P < 0.05). Nurses in the study group scored higher than the control group on the following scales: Perceived Occupational Benefit Scale, General Self‐Efficacy Scale, and Karlausk/Miller Satisfaction Scale (P < 0.05). The case study‐based group‐shared care management model can reduce the risk and harm of adverse events in hospitals and improve nurses’ sense of professional benefit and self‐efficacy.
A Data Mining-Based Method for Quality Assessment of Ideological and Political Education in Universities
Authors: Li Mingzhen
Published: August 2022

The procedure of assisting learning, gathering of information, skills, values, morals, beliefs, habits, and personal growth, is referred to as education. Education should focus not only on developing students’ professional abilities but also on developing and guiding students’ ideological and political perspectives. The purpose of the ideological and political education is to promote Marxist and sociology theories with Chinese features, as well as to bring students together for learning about the development of Marxist theory in China and the path to Chinese political identification. Students will be able to understand the superiority and scientific nature of socialism theory with Chinese characteristics along with actively preserving the socialism development path with Chinese characteristics. However, there are multiple weaknesses in the current evaluation of ideology and political science quality of teaching, including a misaligned evaluation goal, one object, and one-way evaluation. In order to solve these weaknesses, this study proposes an Apriori improvement approach for mining statistics from college political science classes. The important elements affecting instructors’ teaching quality are determined through a series of data collecting and data preprocessing procedures, which can assist teachers to improve and increase their teaching level as well as provide a strong foundation for teaching reform and management. During advanced stages, efficient monitoring and administration of teaching quality assessment can improve the scientific structure of teaching quality evaluation, give positive and constructive suggestions for political reform and development, and improve the college’s overall education level.
Machine Learning-Based Relative Performance Analysis of Monocrystalline and Polycrystalline Grid-Tied PV Systems
Authors: Yar Asfand , Arshad Muhammad Yousaf , Asghar Faran , Amjad Waseem , Asghar Furqan , Hussain Muhammad Imtiaz , Lee Gwi Hyun , Mahmood Faisal
Published: August 2022

In this research study, the design and performance evaluation of grid-tied photovoltaic systems has been carried out through experimentation, HelioScope simulation, and black-box machine learning methods for data-driven artificial intelligence system performance assessment and validation. The proposed systems are based on 15 kWp of monoperk and polyperk, which are separately installed in the industrial sector of Faisalabad, Pakistan. The experimental evaluation of the installed PV modules was performed from November 2020 to August 2021. The performance of the PV modules was evaluated by determining the annual average daily final yield (If), performance ratio (PR), and capacity factor (CF). The study showed that the annual average of daily final yield, performance ratio, and capacity factor for 15 kW polyperk was estimated to be 61.94 kWh, 84.17%, and 19.12, respectively. The annual average of daily final yield, performance ratio, and capacity factor for 15 kW monoperk was estimated to be 58.32 kWh, 81.42%, and 18.13, respectively. A comparison of final yield is obtained from simulation and real-time systems obtained from polyperk PV and monoperk. A significant mean error exists between the experimentation and simulation results which lie within the range of 1250 to 1470 kWh and 1600 to 1950 kWh, respectively. Substantial differences between both aforementioned results were initially tested and highlighted by statistical values; i.e., the standard error lies in-between 5 and 45% in polyperk crystalline and 5 and 25% in monocrystalline PV grid-connected module. Machine learning logistical regression evaluated that monoperk crystalline grid-connected system, experimental work was found to be more reliable with error difference reduces in off-peak months as compared to corresponding simulation study and vice versa for polyperk crystalline grid-connected system. Model accuracy after training and testing produced resulted up to 99.5% accuracy for either grid-connected experimentation or simulation outcomes with validation.
On a Novel Topology of Matrix Converter Applied to Accelerator DC Power Supply
Authors: Wang Bin , Song Weizhang , Si Yang
Published: August 2022

The current topology schemes of heavy ion accelerator power supply have serious pollution to the power grid caused by low power factor of the grid side. Considering the characteristics of adjustable power factor and bidirectional energy transfer of the matrix converter, the possibility of which applied to the accelerator DC power supply is studied and three kinds of backup topology schemes including the preceding regulated matrix rectifier (MR) are proposed in this article. Given the actual situation of accelerator power supply, research has been focused on the modulation strategy suitable for the topology of the preceding regulated MR and simulation validation. Based on simulation of the preceding regulated MR scheme, a matrix power prototype is developed. A power factor tester is utilized to test grid side power factor. According to the experimental results, it is prospectively feasible to apply the preceding regulated MR topology to accelerator DC power supply, with excellent performance of the grid side.
Calycosin Inhibits the Malignant Behaviors of Lung Adenocarcinoma Cells by Regulating the circ_0001946/miR-21/GPD1L/HIF-1α Signaling Axis
Authors: Zhou Lixia , Chen Wenxian , Yang Hang , Liu Jiaqin , Meng Hui
Published: August 2022

Objective. To clarify the potential function and molecular mechanism of calycosin in lung adenocarcinoma (LUAD) cells. Methods. LUAD cells (A549 and H1299) were treated with calycosin at different concentrations (25 nM, 50 nM, and 100 nM) for 24 h. The colony formation, invasion, and migration of the cells were assessed by colony formation, transwell, and scratch assays, respectively. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to determine the mRNA expression level of circ_0001946, miR-21, glycerol-3-phosphate dehydrogenase 1 like (GPD1L), and hypoxia-inducible factor-1α (HIF-1α) in clinical tissue samples and LUAD cells. RNA pull-down assay and dual-luciferase reporter assay were performed to verify the relationship among circ_0001946, miR-21, GPD1L, and HIF-1α. Western blot was performed to detect the protein expression of epithelial-mesenchymal transition (EMT) process-related genes (E-cadherin, N-cadherin, and snail) and GPD1L as well as HIF-1α. Results. Calycosin inhibited colony formation, invasion, migration, and EMT progression in A549 and H1299 cells. Besides, calycosin was able to regulate the expression of circ_0001946, miR-21, GPD1L, and HIF-1α in LUAD cells. According to the findings of QRT-PCR, the expression level of circ_0001946 and GPD1L in LUAD tissues was significantly lower than that in adjacent noncancerous normal tissues, and the expression of miR-21 and HIF-1α was also significantly increased in clinical tissue samples. In addition, there was a targeted regulatory relationship among the above four expressions. Knockdown of circ_0001946 expression in A549 cells treated with calycosin enhanced the malignant behavior of A549 cells and inhibited the anticancer effect of calycosin. However, the knockdown of miR-21 promoted the anticancer effect of calycosin and inhibited the malignant behavior of A549. Conclusion. Calycosin can inhibit colony formation, invasion, migration, and EMT process of LUAD cells via regulating the circ_0001946/miR-21/GPD1L/HIF-1α signaling axis and could be a promising therapeutic drug for LUAD.
Reforming the Teaching of Engineering Cost Budgeting Majors by Integrating VR and BIM Technology under the Internet of Things
Authors: Zhang Yanfen , Mo Haijun
Published: August 2022

With the continuous development of digital technology and the Internet of Things (IoT), the teaching methods for architecture major in higher vocational colleges have also undergone major changes. New technologies and instruction methods in Engineering Cost Budgeting teaching can stimulate students’ learning interest and improve education quality and students’ comprehensive learning ability. In order to improve the teaching level of engineering cost budgeting major and stimulate students’ interest in learning, this work first introduces backpropagation neural network (BPNN) into engineering cost estimation (ECE). Then, the BPNN-based ECE model is trained by the sample data to estimate the project’s total quotation and comprehensive unit price. The error between the real and predicted values is analyzed. Second, the building information modeling (BIM) technology and virtual reality (VR) technologies are integrated into teaching engineering cost budgeting. The investigation, research, and analysis are conducted before and after applying BIM and VR technology in practical teaching. The results show that the proposed BPNN-based ECE model-estimated total quotation and comprehensive unit price fit well the sample values. The BPNN-based ECE model can be applied to teaching engineering cost budgeting. It can improve the calculation accuracy, and the relative error can be controlled within a certain range and has a certain potential to replace manual budgeting. It can provide some reference for the research of engineering cost technology. Classroom teaching under the integration of BIM and VR technologies can improve the students’ homework quality, academic performance, and teaching quality to a certain extent. Integrating BIM and VR technology in classroom teaching can enhance students’ communication, cooperation ability, oral defense scores, comprehensive scores, and professional skills.
Mindfulness‐Based Interventions for the Occurrence of Postpartum Depression in Elderly Primiparas
Authors: Mei Rui , Peng Fan , Xiong Jing , Liu Chanyuan , Liu Xiu , Wang Fang , Lv Lu
Published: August 2022

This study aimed to investigate the independent risk factors for the occurrence of postpartum depression (PPD) in elderly primiparas and the effect of mindfulness‐based intervention (MBI) on improving the PPD. Two hundred cases of elderly primiparas who underwent delivery in our hospital from January 2016 to December 2019 were enrolled as study participants and divided into an occurrence group (n = 60) and a nonoccurrence group (n = 140) according to whether they developed PPD. The occurrence group was divided into a study group (n = 30) receiving MBI and a control group (n = 30) without any intervention. Independent risk factors influencing the occurrence of PPD were identified using univariate and multivariate logistic regression analyses. The effect of the intervention was also analyzed in the study group. Education level, marital status, household monthly income per person, sex of the newborn, milk volume, sleep quality, and relationship with in‐laws were risk factors for the development of PPD. After the intervention, Five Facet Mindfulness Questionnaire scores were increased in the study group and were higher than in the control group (P < 0.05). The study group also exhibited higher 10‐item Connor‐Davidson Resilience Scale scores, lower Hamilton Depression Rating Scale and Schizophrenia Quality of Life Scale scores than the control group (P < 0.05). A variety of independent risk factors affected the occurrence of PPD in elderly primiparas, and MBI should be targeted clinically to reduce their negative emotions, increase psychological resilience, and improve their quality of life.
Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis
Authors: Vitales-Noyola Marlen , Hernández-Castro Berenice , Alvarado-Hernández Diana , Baranda Lourdes , Bernal-Silva Sofía , Abud-Mendoza Carlos , Niño-Moreno Perla , González-Amaro Roberto
Published: August 2022

Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized, among others, by tissue damage and activation/differentiation of proinflammatory lymphocytes. Accordingly, several studies have concluded that type 17 T helper (Th17) cells seem to have an important role in the pathogenesis of this condition. However, the strategy for the identification and analysis of proinflammatory Th17 cells in those studies has not been consistent and has usually been different from what was originally described. Therefore, we decided to evaluate the levels of Th17 cells in patients with RA employing an extended immune phenotype by using an eight-color multiparametric flow cytometry analysis. For this purpose, blood samples were obtained from 30 patients with RA and 16 healthy subjects, and the levels of Th17 and type 22 helper (Th22) lymphocytes were analyzed as well as the in vitro differentiation of peripheral blood mononuclear cells into Th17 lymphocytes induced by interleukin-23 (IL-23) and IL-1β. We found significant enhanced levels of total Th17 lymphocytes (defined as CD4+IL-17+) as well as enhanced numbers of their pathogenic (defined as CD4+CXCR3+IL-17+IL-22+CD243+CD161+IFN-γ+IL-10-) and nonpathogenic (CD4+CXCR3+IL-17+IL-22-CD243-CD161-IFN-γ-IL-10+) cell subsets in patients with RA. Likewise, the number of Th22 (CD4+CXCR3+/-IL-17-IL-22+) was also increased in these patients compared to healthy controls. However, the in vitro induction/differentiation of pathogenic Th17 cells showed similar results in controls and patients with RA. Likewise, no significant associations were detected in patients with RA between the levels of Th17 or Th22 cells and clinical or laboratory parameters. Our data indicate that patients with RA show enhanced blood levels of the different subsets of Th17 cells and Th22 lymphocytes tested in this study and suggest that these levels are not apparently associated with clinical or laboratory parameters.
Digital Technology of Image Acquisition System of Microscope and Its Application in Digital Protection of Grottoes Art
Authors: Yue Jingya
Published: August 2022

Grottoes are the cultural heritage left by ancient people to modern people, and murals in grottoes can leave a lot of information. In order to further improve the relevant information of grottoes and meet the needs of various applications of images, this paper studies the application of digital technology of image acquisition system of microscope in the digital protection of grottoes art. In this study, the digital technology of the image acquisition system of the microscope is used to collect the photos of the grottoes, and then, the photos without the microscope image acquisition system are compared. At the same time, the electronic equipment is used to carry out local measurement and real scene shooting to supplement the scanning data, establish the grottoes database, and then carry out a questionnaire survey on the development of the popularity of grottoes art on the social network. The results of this study show that more than 90% of the people do not know much about the art of grottoes, but they have a positive attitude towards its value and interest. In addition, this study uses different splicing methods to get the panorama of the two grottoes, with the reduction degree of 80%, 89.4%, and 78%, respectively, which better shows the art of the panorama of the grottoes sculpture. It can be seen that the digital technology of the image acquisition system of the microscope can better collect the photos of the grottoes, improve the accuracy and splicing accuracy of the photos, better restore the status quo of the grottoes, establish the art database of the grottoes, achieve the purpose of spreading and promoting the art and culture of the grottoes and digital protection of the grottoes, and inject a helping hand into the internationalization of the folk art of our country.
A Fuzzy Comprehensive Dynamic Evaluation Algorithm for Human Resource Quality Growth Based on Artificial Intelligence
Authors: Guo Qiang
Published: August 2022

In the 21st century, the era of knowledge economy is coming. Today, when the management concept of “people-oriented” is advocated, the value of human resources is more and more prominent, and the evaluation of the value of human resources is more and more important. From the perspective of economic development, as the only dynamic resource, the important role of human resources in creating social wealth has gained a global consensus. The rational allocation of human resources has a decisive impact on the sustainable development of social economy. Among them, Colleges and universities, as the base for the country to transmit talents, take into account the training and the gathering of talents. The core of the work is college teachers. Therefore, the quantity and quality of college teachers are not only related to the development of colleges and universities but also to the comprehensive quality and competitiveness of the country. Fuzzy comprehensive evaluation methods have different advantages and disadvantages. However, the case analysis proves that the fuzzy comprehensive evaluation method is used to judge the human resource management situation in colleges and universities. Influencing indicators is a quantifiable and predictive scientific method. Based on this, this paper proposes a fuzzy comprehensive evaluation method to evaluate the teacher resources of G College in place A. The experimental results of this paper show that due to the comprehensive effect of each element, the comprehensive evaluation of the first-level evaluation index elements of the human resource management value evaluation system of G College reaches 84%. The comprehensive evaluation of the secondary evaluation indicators of the human resource management value evaluation system reached 72%.
Expression and Clinical Significance of HER2 Gene and DNMT1 in Non-Small-Cell Lung Cancer
Authors: Diao Weiying , Ding Chenglong , Yuan Boyang , Li Zan , Sun Na , Huang Jiabin
Published: August 2022

Objective. To explore the expression and clinical significance of HER2 and DNMT1 in non-small-cell lung cancer. Methods. The patients with non-small-cell lung cancer treated in the First Affiliated Hospital of Jiamusi University between 2018 and 2020 were enrolled in this study. The serum DNMT1 concentration and the expression of HER2 protein in lung cancer and adjacent tissues of the two groups were analyzed. Results. The DNMT1 protein concentration was significantly correlated with gender, age, and smoking history of patients. HER2-positive expression was significantly related to tumor type, tumor size, tumor differentiation degree, and lymph node metastasis. However, HER2 levels were not related to the gender and smoking history of patients. Conclusion. High expression of DNMT1 protein in serum may increase the risk of non-small-cell lung cancer and may play an important role in the early development of lung cancer. HER2-positive expression may promote the development of advanced and metastatic non-small-cell lung cancer.
Thymol Disrupts Cell Homeostasis and Inhibits the Growth of Staphylococcus aureus
Authors: Li Qingxiang , Huang Ke Xing , Pan Sheng , Su Chun , Bi Juan , Lu Xuan
Published: August 2022

Staphylococcus aureus (S. aureus) is a typical kind of symbiotic bacteria, which can cause human pneumonia, food poisoning, and other health problems. Nowadays, the corresponding prevention and treatment have been a hot issue of general concern in related research areas. However, the mechanism of action against S. aureus is not well understood. In order to tackle such problem, we used broth microdilution to discuss the antibacterial effect of 5‐methyl‐2‐isopropylphenol and determine inhibitory concentration. In addition, membrane potential and lipid peroxidation levels were also measured under experimental conditions. The experimental results suggested that 300 μg/mL thymol might cause cell membrane damage and decrease of NADPH concentration and increase of NADP+ and lipid peroxidation level. In such condition, thymol has the potential to result in membrane rupture and disruption of cellular homeostasis. Furthermore, we also found that NOX2 is involved in maintaining the balance of NADPH/NADP+ in cells. Finally, our work confirms that NOX2 is a potential downstream target for thymol in the cell. Such target can provide specific guidance and recommendations for its application in antifungal activity. Meanwhile, our study also provides a new inspiration for the molecular mechanism of thymol’s bacteriostatic action.
Integration and Recommendation of Multimedia Network-Assisted English Instructional Resources Based on Association Rules Mining
Authors: Liu Lihong
Published: August 2022

The integration of multimedia teaching refers to a novel teaching mode that combines multimedia, information resources, and information methods with content and teaching process in the teaching process with the guidance of contemporary educational ideas and organically unifies them on a spatial and temporal platform, so as to better accomplish the teaching tasks. However, with the deepening of network teaching and school connotation construction, various resources such as media materials, courseware, network courses, and teaching cases generated by education and teaching, as well as academic works, papers, patents, project results, and lectures of experts and professors gathered by scientific research, are increasing. In this situation, how to integrate teaching resources and courses to provide students with an independent learning platform and an information-based learning environment has become an urgent issue. For this problem, data mining has shown a strong vitality, and data mining can find out the potential connection between datasets. Association rule mining is the most researched and widely used data mining method. In this paper, we propose a multimedia network-assisted English integration of educational resources method based on association rule algorithm to give full play to the role of “multimedia technology” and realize the integration of traditional English teaching and information network culture, so as to achieve the purpose of optimizing English teaching. The experimental results show that with the increase of data volume, the average testing time of Apriori is reduced by 56.49 s compared with MapReduce, so the advantage of Apriori algorithm is more obvious. Therefore, this research can effectively provide students with rich and colorful personalized resources, realize high-performance interactive learning, and help students cultivate their independent learning ability as well as their lifelong learning habits.
An Analysis of the Theta‐Method for Pantograph‐Type Delay Differential Equations
Authors: Rihan Fathalla A. , Rihan Ahmed F.
Published: August 2022

The pantograph equation arises in electrodynamics as a delay differential equation (DDE). In this article, we provide the ϑ‐method for numerical solutions of pantograph equations. We investigate the stability conditions for the numerical schemes. The theoretical results are verified by numerical simulations. The theoretical results and numerical simulations show that implicit or partially implicit ϑ‐methods, with ϑ > (1/2), are effective in resolving stiff pantograph problems.
Responsibility as a factor in the development of family self-determination in adolescence
Authors: Merzlyakova Svetlana V. , Bibarsova Nadia V.
Published: August 2022

Background. National policies and laws determine the speci_cs of family relationship and marriage in di`erent countries. Traditional norms and values that determine the marital and family behavior of young people are weakening with the rapid change in political and economic situation and with the digitalization of society. In this regard it is urgent to study the socio-psychological factors that determine the process of family self-determination in the youth of digital generation. Objective. ae study aims to analyze structural and meaningful characteristics of family self-determination depending on the degree of responsibility among students in adolescence. Sample. ae study involved 326 students of Astrakhan State University aged from 17 to 19 years. aese included 47 (14.4%) male and 279 (85.6%) female students of humanities programmes. Methods. Empirical research was conducted with the use of psychodiagnostic techniques: a modi_ed version of the semantic di`erential methodology by I.L. Solomin, the “Test of life orientations” by D.A. Leontiev, the questionnaire “ae level of the ratio of “value” to “accessibility” in various spheres of life” by E.B. Fantalova, the projective technique “Incomplete sentences”, the questionnaire “Role expectations and claims in marriage” by A.N. Volkova, multidimensional functional diagnostics of responsibility by V.P. Pryadein. Regression analysis made it possible to assess the impact of responsibility on indicators of family self-determination. Results. It is shown that responsibility determines the development of cognitive, value-emotional, regulatory-behavioral, motivational and rebexive components of family self-determination in adolescence. Responsibility has been found to have the greatest impact on the meaningfulness of life (determination coeccient R2 = 0.203) as well as on role claims in the sphere of social activity (R2 = 0.179). Conclusion. Responsibility is a signi_cant micro-level factor determining the process of family self-determination in adolescence. ae development of responsibility among students will allow to form a holistic image “Me as a family person”, to cultivate the values of marriage and family relations and life orientations, to integrate ideas on the time perspective, to reduce the number of extramarital births as a result of the actualization of parenthood as an important marriage motive. Practical application of the results. ae materials of the conducted research can be used in the development and implementation of educational programmes at institutions of higher education. aey can also be used to promote psychological and pedagogical conditions for self-determination in the sphere of marital and family relations through the development of responsibility among modern students.
Boot camp: Training and dressing regimens for modeling plantar wounds in the swine
Authors: Stalnaker Katherine J , Fuchs Christiane , Slate Andrea , Camacho Jennifer N , Pham Linh , Wang Ying , Anderson R Rox , Tam Joshua
Published: August 2022

Foot ulceration annually affects millions of patients and accounts for billions of dollars in medical expenses in the US alone. Many previous studies have investigated co-morbidities associated with impaired healing, such as microbial infection, compromised circulation, and diabetes. By comparison, little is known about how wound healing proceeds in plantar skin, despite its many unique specializations related to its load-bearing function. One of the main challenges in modeling plantar wounds is the difficulty in maintaining wound dressings, as animals generally have a low tolerance to wearing bandages on their feet. With assistance from the MGH Center for Comparative Medicine, we developed a positive reinforcement-based behavioral training regimen that successfully induced tolerance for plantar dressings in swine, which is a critical first step towards enabling in vivo study of the wound healing process in this highly specialized skin area. This training program will be described in detail in this manuscript.