bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU
Authors: Hu Xin , Ji Yikang , Zhang Mi , Li Zhihui , Pan Xinhua , Zhang Zhen , Wang Xu
Published: February 2025

Background

Although nutrition-starvation therapy for malignancies such as HNSCC is highly desirable, the clinical outcomes remain disappointing. Understanding the spatial heterogeneity of glucose deficiency can reveal the molecular mechanisms regulating cancer metabolism and identify therapeutic targets to improve effective nutrient-starvation therapies.

Methods

Multiple omics data from RNA-seq, proteomics and spatial transcriptome analyses of HNSCC samples were integrated to analyze the spatial heterogeneity of glucose deficiency. In vivo and in vitro CXCL8 and CLU expression levels in tumor cells were determined using qPCR, immunohistochemistry and ELISA. The ability of CLU from TAMs to respond to tumor-derived CXCL8 was assessed using RNA sequencing, siRNA silencing, immunofluorescence and CCK-8 assays. A mouse subcutaneous xenograft model was used to assess the outcomes of nutrition-starvation therapy combined with blockade of CXCL8 signaling.

Results

A set of genes that was significantly upregulated in HNSCC under conditions of glucose deficiency was identified using integrating multiple omics data analyses. The upregulated gene set was used to determine the glucose-deficient area according to transcriptome data of HNSCC, and CXCL8 was one of the most highly upregulated genes. The levels of both CXCL8 mRNA and its protein IL-8 in cancer cells under conditions of glucose deficiency were increased in an NF-κB-dependent manner. Supplementary IL-8 stimulated TAMs to synthesize CLU, and CLU counteracted oxidative stress in HNSCC cells under conditions of glucose deficiency. Moreover, pharmacological blockade of CXCL8 signaling (reparixin) sensitized HNSCC cells to nutrient-starvation therapy (anlotinib) in two xenograft models.

Conclusion

Our results provide novel evidence of a feedback loop between cancer cells and TAMs in glucose-deficient regions. HNSCC-derived CXCL8 favors endogenous antioxidative processes and confers therapeutic resistance to nutrient-starvation therapies in HNSCC.

Graphical Abstract
Developing a risk score using liquid biopsy biomarkers for selecting Immunotherapy responders and stratifying disease progression risk in metastatic melanoma patients
Authors: Azzariti Amalia , De Summa Simona , Marvulli Tommaso M. , De Risi Ivana , De Palma Giuseppe , Di Fonte Roberta , Fasano Rossella , Serratì Simona , Strippoli Sabino , Porcelli Letizia , Guida Michele
Published: February 2025

Background

Despite the high response rate to PD-1 blockade therapy in metastatic melanoma (MM) patients, a significant proportion of patients do not respond. Identifying biomarkers to predict patient response is crucial, ideally through non-invasive methods such as liquid biopsy.

Methods

Soluble forms of PD1, PD-L1, LAG-3, CTLA-4, CD4, CD73, and CD74 were quantified using ELISA assay in plasma of a cohort of 110 MM patients, at baseline, to investigate possible correlations with clinical outcomes. A clinical risk prediction model was applied and validated in pilot studies.

Results

No biomarker showed statistically significant differences between responders and non-responders. However, high number of significant correlations were observed among certain biomarkers in non-responders. Through univariate and multivariate Cox analyses, we identified sPD-L1, sCTLA-4, sCD73, and sCD74 as independent biomarkers predicting progression-free survival and overall survival. According to ROC analysis we discovered that, except for sCD73, values of sPD-L1, sCTLA-4, and sCD74 lower than the cut-off predicted lower disease progression and reduced mortality. A comprehensive risk score for predicting progression-free survival was developed by incorporating the values ​​of the two identified independent factors, sCTLA-4 and sCD74, which significantly improved the accuracy of outcome prediction. Pilot validations highlighted the potential use of the risk score in treatment-naive individuals and long responders.

Conclusion

In summary, risk score based on circulating sCTLA-4 and sCD74 reflects the response to immune checkpoint inhibitor (ICI) therapy in MM patients. If confirmed, through further validation, these findings could assist in recommending therapy to patients likely to experience a long-lasting response.
GeoTemporal clustering for aquifer delineation: a big data approach to synchronizing and analyzing variable-length groundwater time series
Authors: ElHaj Khalid , Alshamsi Dalal
Published: February 2025

Groundwater is a vital global resource. However, mapping aquifers remains challenging, particularly in developing nations. This study proposes a novel methodology for aquifer delineation using time-series clustering of groundwater-level data. The modular clustering framework utilizes hierarchical agglomerative clustering and a custom hydrology-specific distance function. This accounts for the variability in the length, temporal position, and consistency of the time series, in addition to gaps in records, aligning them temporally before comparison. Advantages over traditional techniques such as dynamic time warping, and Euclidean distance are provided for analyzing real-world hydrological data. The algorithm was optimized on a synthetic Texas aquifer dataset to identify the minimum time series lengths required for accurate clustering (> 90% accuracy). Applying this to real data from the Texas Groundwater Database GWDB with over one million readings and 60,000 wells, the modeling achieved ~ 73% accuracy, delineating the nine major Texan aquifers using a filtered number of 74 representative wells. The aquifer boundaries were geographically visualized using the GeoZ library. These findings suggest the effectiveness of groundwater characterization given the limited data. The optimized algorithm could provide inexpensive mapping capabilities in developing nations, requiring only historical data from existing wells over the decades. This technique is adaptive and can be improved through ongoing monitoring. The algorithm components are modular and upgradable thus future studies should optimize and test their generalizability using additional datasets.
How to help children succeed: the impact of parenting styles on access to quality higher education
Authors: Xu Danhong , Gui Yong
Published: February 2025

What type of parenting style can help children succeed? Academic discussions on this issue are divided into two different theoretical perspectives: cultural reproduction and cultural mobility. This study uses data from the 2017 Survey on the Social Mentality of Chinese College Students to empirically analyze the impact of parenting styles on children’s access to quality higher education. The results indicate that parenting styles not only act as an intermediary mechanism of family socioeconomic status in influencing children’s access to quality higher education but also have an independent effect. Among the various parenting styles, permissive parenting style is more conducive to children gaining admission to elite universities.
Social network analysis of key stakeholders in Brucellosis prevention in Western Iran
Authors: Behzadifar Meysam , Yarahmadi Mohammad , Bakhtiari Ahad , Kargar Sahar , Shahabi Saeed , Azari Samad , Martini Mariano , Behzadifar Masoud
Published: February 2025

Background

Brucellosis remains a persistent public health challenge in Iran, particularly in rural regions such as Lorestan province, due to systemic, economic, and cultural barriers. Effective disease control requires multisectoral collaboration among stakeholders. This study aimed to map the stakeholder network involved in brucellosis prevention in Lorestan province, identify gaps in coordination, and provide actionable recommendations for improving control strategies.

Methods

This cross-sectional study employed social network analysis (SNA) to explore the relationships among key stakeholders in brucellosis prevention. Data were collected through a structured questionnaire administered to 75 experts from various sectors, including health, veterinary, agriculture, and non-governmental organizations. The SNA evaluated network density, clustering coefficient, and centrality metrics to determine the levels of collaboration and influence among stakeholders.

Results

The analysis revealed a moderately dense network (density: 0.2745; clustering coefficient: 0.2839) with central roles played by the Veterinary Organization of Lorestan Province, Lorestan University of Medical Sciences, and the Ministry of Agriculture. These organizations exhibited high levels of influence, support, and interest in brucellosis prevention. However, limited involvement of community-based organizations and environmental agencies was identified, highlighting a critical gap in grassroots engagement. Fragmented coordination was particularly evident in rural areas, where traditional livestock practices, inadequate veterinary services, and the consumption of unpasteurized dairy products perpetuate disease transmission. Economic constraints, such as the high cost of vaccines, along with limited public awareness, further hinder effective control efforts.

Conclusions

Brucellosis prevention in Lorestan province requires a comprehensive, multisectoral approach. The adoption of a One Health framework can improve collaboration among stakeholders, enhance resource allocation, and address systemic barriers. Community engagement and intersectoral coordination are essential for improving public awareness and compliance with preventive measures. These findings provide a foundation for developing a National Brucellosis Control Program and inform strategies to mitigate zoonotic diseases in similar high-risk regions.
Entrepreneurial strategies for sustainable growth: a deep dive into cloud-native technology and its applications
Authors: Alka T. A. , Sreenivasan Aswathy , Suresh M.
Published: February 2025

The study highlights the impact of cloud-native technology in entrepreneurship for innovative business models, scalability, and cost efficiency by combining the trends including microservices, serverless computing, and technology disruptions. The study attempts to examine the role of cloud-native technology affects the entrepreneurial landscape in creating and advancing innovative business models and approaches, and the difficulties while applying cloud-native technology. The systematic literature review based on PRISMA is used to explore cloud-native technology and its applications by analyzing selected 111 studies from Scopus, Web of Science, Dimensions, and ProQuest. The study identified that one of the main forces behind disruption is the quick development of new technologies including blockchain, 5G, IoT, quantum computing, and AI. Cloud-native technology supports innovative business models in entrepreneurship such as SaaS, serverless computing, managed Kubernetes, data analytics platforms, BaaS, and Edge Computing. The urgency to incorporate and develop new security features and tools for measurement is necessary. The study shows that startups can use cloud-native technologies for innovative business models that rely on serverless computing, subscription services, and on-demand cloud services which are providing opportunities. The findings of the study highlight the need for entrepreneurs to utilize emerging technologies to meet competition, and there is a requirement for continuous investment in data analytics, automation, cloud solutions, and emerging technologies. Collaboration is essential for the application of the technologies for early stage startups and enterprises. Incubators, accelerators, and venture capital firms support essential to the adoption of disruptive technologies. The policymaker's and enterprises' focus and actionable intervention are necessary for developing mechanisms to solve the barriers of regulatory compliance, lack of skilled manpower, data security, privacy issues, and upfront investment for entrepreneurial success.
Cancer multi-omics-based differential expression analysis and prognostic potential of identified hub targets of myco-metabolites for breast carcinoma and lung carcinoma
Authors: Shreya Singh , Mohapatra Debadatta , Naik Gaurav Gopal , Kathait Pooja , Malang Soki , Patel Pradeep , Shambhavi  , Alam Gulzar , Sahu Alakh N.
Published: February 2025

Background

Breast carcinoma (BC) and lung carcinoma (LC) have the highest incidence and mortality rates worldwide. In prior work, studied sample hub targets contributing to anticancer potential against BC and LC were identified through network pharmacology. In the present work, web servers UALCAN, GEPIA2, and KM plotter were used to explore the genomic and proteomic expression of these hub targets, along with their prognosis potential in BC and LC.

Results

Differential hub targets SRC, MAPK3, PTPN11, JAK2, ESR1, and HAP900A1 for BC and PTPN11, JAK2, ESR1, EGFR, and MAPK3 for LC, showed good prognostic potentials. Collectively, PTPN11, JAK2, and ESR1 were overlapped differential expressed hub targets involved in the significantly good prognosis of both carcinoma.

Conclusion

These differentially expressed hub targets may be taken into account for future BC and LC treatments due to their strong prognostic potential.
Path analysis of farmer knowledge, attitudes, and practices toward lumpy skin disease in beef cattle
Authors: Khan Sohrab , Addoddon Darawan , Prapapanpong Jutamas , Suwannaboon Minta , Arjkumpa Orapun , Na-Lampang Kannika , Chaisowwong Warangkhana , Srisawang Supitchaya , Punyapornwithaya Veerasak
Published: February 2025

Lumpy skin disease (LSD) poses a significant threat to cattle populations and the livelihoods of farmers in Thailand. This study uses path analysis to explore the interrelationships among the knowledge, attitudes, and practices (KAP) of beef cattle farmers regarding LSD. A total of 384 farmers provided data on their sociodemographic characteristics and responses to KAP-related questions. Path analysis was employed to examine how KAP components interact and how demographic factors influence these relationships. The analysis revealed strong positive relationships between farmers’ knowledge and attitudes (β = 0.96, p < 0.001) and between attitudes and practices (β = 0.08, p < 0.008). Farmers with greater knowledge of LSD were more likely to adopt positive attitudes toward disease control and implement effective management practices. Additionally, knowledge had a direct influence on farmers’ practices (β = 0.38, p < 0.001), indicating that improved awareness of LSD is linked to better disease management. By strengthening knowledge, these efforts can positively influence attitudes and practices, leading to more effective control strategies. As the first KAP study on LSD in Thailand, this research highlights the critical role of targeted education programs in improving farmers’ understanding of LSD. Ultimately, enhancing disease management through education can help reduce the economic impact of LSD on Thailand’s livestock sector and promote sustainable farming practices.
Avascular Necrosis in Patients With Cushing Syndrome
Authors: Tal Noa , Bannykh Serguei , Learch Thomas , Mamelak Adam N , Cooper Odelia
Published: February 2025

Cushing syndrome (CS) results from prolonged exposure to excess glucocorticoids, leading to a range of clinical manifestations including avascular necrosis (AVN), a rare complication of CS. Although AVN is often associated with exogenous glucocorticoid treatment, it can occur in endogenous CS but may be unrecognized because of its rarity and possibly from a subclinical presentation. We describe a case of a 71-year-old male with florid Cushing disease who initially presented with bilateral hip AVN and later developed bilateral shoulder AVN despite achieving biochemical remission following transsphenoidal surgery and adjuvant stereotactic photon radiosurgery. AVN in endogenous CS is underreported, and guidance on routine screening is lacking. Our case underscores the importance of considering AVN in patients with CS, especially in those with persistent or recurrent joint symptoms and markedly elevated cortisol levels. Early detection of AVN is crucial as it can lead to irreversible joint damage and disability if untreated. Screening strategies should be explored to identify high-risk patients who are diagnosed with CS for timely intervention, thereby preventing long-term morbidity associated with AVN.
A New Method for Comprehensive Analysis of Benzodiazepine, Opioid, and Propofol Interactions and Dose Selection Rationales in Gastrointestinal Endoscopy Sedation
Authors: Liou Jing-Yang , Wang Hsin-Yi , Kuo I-Ting , Tsou Mei-Yung , Chang Weng-Kuei , Ting Chien-Kun
Published: February 2025

BACKGROUND:

The aim of this study was to explore a new method for determining optimal dosing regimens for combinations of propofol, midazolam, and an opioid to achieve rapid on- and off-set of deep sedation.

METHODS:

We simulated 16 published dosing regimens using a well-validated pharmacodynamic model. The study was divided into 2 parts. First, the regimen that best provided deep sedation and rapid recovery was selected. A deep sedation-time area-under-the-curve (AUC) method was used to compare published dosing regimens; a higher AUC indicated better sedation and faster recovery. Second, subgroup analysis of the best-performing dosing regimen was undertaken better to understand how each drug affected patient recovery.

RESULTS:

The AUC method identified a combination of midazolam 1 mg, alfentanil 500 µg, and propofol target infusion effect-site concentration (Ce) 2 µg mL−
1 as the optimal regimen (P < .01). Propofol correlated with high probability of sedation and increased AUC (R2 = 0.53), whereas midazolam had a significant impact on time to return of consciousness (R2 = 0.86). Subgroup analysis indicated that regimens consisting of a fixed dose of alfentanil and either 5 µg mL−1 Ce propofol, or 1 mg midazolam with 3–5 µg mL−1 Ce of propofol, or 2 mg midazolam with 2 µg mL−1 Ce propofol provided adequate sedation and rapid recovery. Midazolam >3 mg greatly prolonged recovery.

CONCLUSIONS:

This study used a clinically relevant method and model simulation to determine suitable sedation regimens for use in gastrointestinal endoscopy. A balanced propofol, midazolam, and an opioid should be used. The AUC method was capable of providing objective assessments for model selection.
Effect of Low-Dose Ketamine Infusion in the Intensive Care Unit on Postoperative Opioid Consumption and Traumatic Memories After Hospital Discharge: A Randomized Controlled Trial
Authors: Kitisin Nuanprae , Raykateeraroj Nattaya , Hemtanon Nattachai , Kamtip Piyawuth , Thikom Napat , Azimaraghi Omid , Piriyapatsom Annop , Chaiwat Onuma , Eikermann Matthias , Wongtangman Karuna
Published: February 2025

BACKGROUND:

Low-dose ketamine may have an opioid-sparing effect in critically ill patients but may also predispose them to traumatic memories. We evaluated the effects of low-dose ketamine infusion in the intensive care unit (ICU) on fentanyl consumption and traumatic memories after hospital discharge.

METHODS:

This randomized, double-blind, controlled trial was conducted at a university-based surgical ICU. 118 adult patients who were admitted to the ICU after noncardiac, nonneuro, nontrauma surgery between March 2019 and May 2021 were randomized to receive ketamine 1.5 µg/kg/min (n = 60) or placebo (n = 58). Fentanyl was given to achieve pain control (10-point numerical rating scale pain score [NRS] < 4) and sedation control (Richmond Agitation and Sedation Scale [RASS] level between −2 and 0). A secondary study was conducted by a telephone interview after ICU discharge using the Thai version of the posttraumatic stress disorder (PTSD) questionnaire to evaluate signs and symptoms of PTSD and traumatic memories to the time spent in the ICU.

RESULTS:

24-hour fentanyl consumption was lower in patients who received ketamine compared with placebo (399 µg [95% confidence interval {CI}, 345–454] vs 468 µg [95% CI, 412–523], difference −68 µg; 95% CI, −67 to −69; P = .041); RASS and NRS scores did not differ between the 2 groups. Exploratory effect modification analysis suggested that the opioid-sparing effect of ketamine may be more relevant in patients with intraabdominal surgery (P-for-interaction = 0.012, difference, −177 µg; 95% CI, −204 to −149 µg; P = .001). No acute adverse effects of ketamine were observed. The secondary study included the information from 91 patients from the primary study. Long-term follow-up data was available for 45 patients (23 in the control group, 22 in the ketamine group), and the evaluations were taken 43 ± 8 months after ICU discharge. In this secondary study, ketamine use was associated with a higher incidence of frightening and delusional memories of critical illness and ICU treatment (65% vs 41%, P = .035).

CONCLUSIONS:

Low-dose ketamine is associated with a small but statistically significant reduction (15%) of postoperative opioid consumption in the ICU. Our secondary study revealed that patients who received low-dose ketamine during fentanyl-based postoperative pain therapy in the ICU recalled more frightening and delusional memories after ICU discharge.
Building bridges: allyship as a catalyst for gender diversity and inclusion in experimental biology communities
Authors: Schwaner M. Janneke , Keplinger Ksenia
Published: February 2025

Diversity drives innovation and creativity, directly contributing to scientific excellence. However, achieving equity in academia, including in experimental biology fields such as biomechanics and comparative physiology, remains a significant challenge, with women and other historically marginalized groups underrepresented, especially in more senior roles. When considering gender, the disparity is often linked to difficulties in balancing family responsibilities with demanding careers, along with lower ‘academic visibility’, as evidenced by fewer professional awards for women scientists. Many successful women who balance career and family keep their family lives private, making these aspects invisible to early career scholars, and thus depriving them of role models. To help close the gender gap, in this Perspective, we propose 10 actionable strategies for scholars at all career stages to promote gender diversity and inclusion through active allyship. Although we focus on gender diversity, these strategies can be broadly applied to harness the benefits of other diversity dimensions (e.g. age or ethnicity). We argue that embracing allyship benefits individual scientists, their research groups, the quality of their research, the broader research community and society at large by enhancing collective scientific output and inspiring the next generation of scientists.
Η αξιοποίηση του Ψηφιακού Δράματος στην εκπαιδευτική διαδικασία: ενίσχυση του ρόλου του/της μαθητή/τριας
Authors: Καραντζούλη Αιμιλία
Published: February 2025

Το παρόν επιστημονικό άρθρο αποτελεί απόσπασμα από τη διδακτορική διατριβή της γράφουσας με τίτλο «Το Ψηφιακό Δράμα και η Αξιοποίησή του στην Εκπαιδευτική Διαδικασία», που εκπονήθηκε στο Παιδαγωγικό Τμήμα Δημοτικής Εκπαίδευσης ΕΚΠΑ. Επιδιώκεται μέσα από την ενδελεχή μελέτη της διεθνούς βιβλιογραφίας η τεκμηρίωση της ενίσχυσης του ενεργού ρόλου που είναι σε θέση να διαδραματίσουν οι μαθητές/τριες ‒στο πλαίσιο της μαθητοκεντρικής προσέγγισης της εκπαίδευσης‒ μέσα από δραστηριότητες συγκερασμού τεχνικών του Θεάτρου στην Εκπαίδευση και των νέων τεχνολογιών. Ιδιαίτερη έμφαση δίνεται σε κάθε περίπτωση στην έννοια και τη λειτουργία του «ρόλου» στο συγκεκριμένο πλαίσιο. Πραγματοποιείται ανάλυση της δυνατότητα εξερεύνησης της ταυτότητας του μαθητή μέσα από τις δραστηριότητες της υβριδικής μορφής του Ψηφιακού Δράματος και, τέλος, γίνεται αναφορά στην αισθητική καλλιέργεια που μπορεί να επιτευχθεί για το μαθητικό δυναμικό μέσω των αντίστοιχων δραστηριοτήτων. Το άρθρο επιδιώκει να αναδείξει τη μεγάλη δυναμική, καθώς και τα οφέλη που είναι δυνατόν να επιτευχθούν, θέτοντας παράλληλα ερωτήματα και αφορμές για σκέψη και προβληματισμό.
Από τα θεραπευτικά στα καλλιτεχνικά-πολιτικά παραδείγματα: Οι ιστορικά διαμορφωμένες διαστάσεις της τέχνης των αναπήρων και το ελληνικό πολιτισμικό πλαίσιο
Authors: Κολτσίδα Μαρία
Published: February 2025

Η τέχνη που αφορά ανάπηρα άτομα και καλλιτέχνες αποτελεί ένα πεδίο που σταδιακά προσελκύει το ενδιαφέρον ακαδημαϊκών, ερευνητών, καλλιτεχνών και πολιτιστικών οργανισμών στο ελληνικό πλαίσιο. Η σχετικά περιορισμένη ωστόσο θεωρητική και ερευνητική κάλυψη του πεδίου επιτάσσει τη διερεύνηση των διαφορετικών τάσεων που σχετίζονται με τις τέχνες, και ιδιαίτερα το θέατρο και τα ανάπηρα άτομα. Στο πρώτο μέρος της παρούσας μελέτης, διερευνώνται οι διαφορετικές πρακτικές τέχνης που αφορούν ανάπηρα άτομα και καλλιτέχνες, μέσα από συγκεκριμένες −ιστορικά διαμορφωμένες− διαστάσεις. Στο δεύτερο μέρος συζητείται η σχετική έρευνα στο πεδίο και η διάρθρωση της καλλιτεχνικής πρακτικής και εκπαίδευσης των αναπήρων στον ελληνικό πολιτιστικό χώρο. Μέσα από τη θεωρητική ανάλυση των παραπάνω δεδομένων, η μελέτη επιχειρεί να συζητήσει τους τρόπους με τους οποίους οι −ιστορικά διαμορφωμένες− διαστάσεις στην τέχνη που αφορά ανάπηρα άτομα και καλλιτέχνες διαπλέκονται και σχετίζονται με την καλλιτεχνική πρακτική και εκπαίδευση των αναπήρων στον ελληνικό χώρο.
«Δημιουργώντας χώρο ανάμεσα στους Πολιτισμούς»: Η εμπειρία τού να δουλεύεις μαζί με άλλους
Authors: Κακουδάκη Tζωρτζίνα
Published: February 2025

Αυτό το εκπαιδευτικό πρόγραμμα ανταλλαγής έχει ως στόχο να φέρει κοντά σπουδαστές θεάτρου και δραματικών σχολών, ώστε να καθιερωθούν τρόποι με τους οποίους η θεατρική εκπαίδευση και το θέατρο ως τέχνη του θεάματος μπορούν να δημιουργήσουν έναν νέο διάλογο για τη μορφή και το περιεχόμενο, σε παιδαγωγικό και πολιτικό επίπεδο. Δεδομένου ότι οι θεατροπαιδαγωγοί συχνά στερούνται των δεξιοτήτων του θεάματος και οι ηθοποιοί συχνά στερούνται παιδαγωγικών δεξιοτήτων ‒ των μέσων που χρειάζονται για να κατευθύνουν το περιεχόμενο του έργου στους άλλους και την αλληλεπίδραση με το κοινό, το πρόγραμμα επικεντρώθηκε στα εξής:
 Πώς οι σπουδαστές δραματικών σχολών μπορούν να βρουν νέους τρόπους να δημιουργήσουν το περιεχόμενό τους σε κρίσιμα θέματα ‒ προσφέροντας σημαντική συμβολή στη δημιουργική σκέψη και τη δραματουργία.
 Πώς οι σπουδαστές εφαρμοσμένου θεάτρου μπορούν να επικεντρωθούν στη μεθοδολογία της παράστασης, της υποκριτικής και της εκφραστικότητας, αναπτύσσοντας δεξιότητες στη σκηνή.
Η πρόθεση του προγράμματος, το οποίο λειτουργεί σε ετήσια βάση, είναι να δημιουργήσει ένα μονοπάτι για την ενσωμάτωση της τέχνης του θεάτρου και του εφαρμοσμένου θεάτρου στην κοινωνία, ώστε ο ηθοποιός του μέλλοντος να εργάζεται εστιασμένα προς τις ανάγκες της κοινότητας όταν βρίσκεται στη σκηνή και ο θεατροπαιδαγωγός με άρτια αισθητικά καλλιτεχνικά εργαλεία όταν εργάζεται για την κοινότητα.
PROBLEMS OF PERSONNEL POLICY IN THE ACTIVITIES OF SPORTS INSTITUTIONS
Authors: Snytkin Dmitry V.
Published: February 2025

The article examines the main problems of sports institutions in the direction of "Implementation of personnel policy." It has been established that the largest number of unresolved issues is associated with the remuneration system for employees of institutions. An analysis of problems in the field of labor rela-tions showed that institutions lack a system of real measurable results of activi-ty efficiency, often the tools of the "effective contact path" are used "on formal grounds," thereby reducing the motivation of string players and the effective-ness of sports institutions. It has been shown that institutions often lack a methodology for assessing the number of personnel in accordance with the state assignment, which also negatively affects work performance.
Purpose. Identification of the main problems in implementing the personnel policy of sports institutions.
Methodology. The article used methods of synthesis and statistical methods of analysis.
Results. The study of the staff composition of sports institutions has identified a number of problems, including the ageing of personnel, the lack of a staff certification mechanism, high turnover and a marked shortage of personnel.
Practical implications it is expedient to apply the received results by the state, developing strategies of development of industries, as well as in organizations whose activities are related to sports.
ENVIRONMENTAL EFFECTS FROM HARMFUL EMISSIONS OF ANTHROPOGENIC SOURCES OF POLLUTION
Authors: Guzik Vitaly
Published: February 2025

The article attempted to analyze the effects of harmful emissions on the environ-ment. Against the background of tightening environmental standards and stand-ards for emissions of harmful substances, the problem of harmful emissions of pro-duction becomes especially relevant. We are talking about anthropogenic (artifi-cial) pollutants: transport (formed during the operation of road, rail, air, sea and river transport), industrial (formed as emissions during technological processes or during heating) and household (caused by the burning of fuel in housing and pro-cessing of household waste).
Rodzinne i osobowościowe uwarunkowania systemu wartości. Relacja celów wychowawczych rodziców z cechami osobowości i systemem wartości ich dorosłych córek
Authors: Szymańska Agnieszka , Świderska Joanna
Published: February 2025

Doświadczenie, jakiego dziecko nabywa w procesie wychowawczym,kształtuje jego cechy osobowości oraz system wartości. W sposób szczególny mogą jekształtować cele wychowawcze rodziców, czyli cechy osobowości, jakie rodzice pragnąrozwinąć u swoich dzieci, zwane „projektem osobowości”. W badaniu testowano, czycele wychowawcze rodziców współwystępują z cechami osobowości oraz systememwartości ich dorosłych córek. Badanie wykonano na próbie 402 kobiet w wieku od 21do 50 lat. W celu udzielenia odpowiedzi na pytania badawcze zastosowano algorytmy text mining oraz analizę skupień przeprowadzoną przez algorytmy data mining. Wyniki ujawniły, że kobiety, których rodzice starali się rozwinąć w nich cechę Stabilności (Alfa-Plus), jako dorosłe kobiety miały wyżej rozwiniętą tę cechę, a także cechę Integracji osobowości (Gamma-Plus). Kobiety te przypisywały większe znaczenie wartościom związanym z przekraczaniem siebie (życzliwość, uniwersalizm) i zachowawczością (przystosowanie, tradycja, bezpieczeństwo) oraz mniejsze wartościom związanym z umacnianiem siebie (kierowanie sobą, stymulacja) i otwartością na zmiany (hedonizm, osiągnięcia, władza).
The Specific Dermatoses of Pregnancy
Authors: Polańska Paulina
Published: February 2025

Introduction and purpose: Pregnancy-specific dermatoses are a group of pruritic skin disorders that arise exclusively during pregnancy or the postpartum period. They encompass four primary conditions: atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), intrahepatic cholestasis of pregnancy (ICP), and pemphigoid gestationis (PG). This review aims to provide a comprehensive analysis of their prevalence, clinical characteristics, underlying mechanisms, therapeutic strategies, and potential fetal risks.
Results: These dermatoses often present with overlapping clinical features, making accurate differential diagnosis crucial. While some pose minimal risk to the fetus, others, such as ICP and PG, are associated with significant complications, including preterm birth and stillbirth. The underlying pathophysiology remains incompletely understood, with hormonal, immunological, genetic, and environmental factors playing key roles. Treatment strategies focus primarily on symptomatic relief, with topical corticosteroids and oral antihistamines being the mainstay of therapy, while ursodeoxycholic acid is the treatment of choice for ICP. 
Conclusions: A multidisciplinary approach is essential for optimal maternal and fetal outcomes. Further research is needed to better understand the mechanisms and develop more effective treatment options for these conditions.
The Impact of Astaxanthin Supplementation on the Lipid Profile
Authors: Arczewski Filip , Wójcikiewicz Michalina , Czyż Witold , Kacperczyk Julia , Dziedzic Karol , Chuncia-Ileczko Marta , Wojszczyk Maciej , Zys Damian , Pasek Piotr , Ryniecka Julia , Czaja Wiktor , Krzciuk Michał
Published: February 2025

Astaxanthin (AST) is a carotenoid renowned for its strong antioxidant properties and its role as a pigment in various aquatic organisms. Initially isolated from lobster and subsequently characterized in detail, AST has garnered significant interest in recent years within the research, pharmaceutical, cosmetic, and supplement industries. This review aims to synthesize current literature on the impact of astaxanthin supplementation on lipid profiles, specifically focusing on low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. Evidence suggests that AST effectively prolongs the oxidation lag time of LDL, thereby mitigating the risk of atherosclerosis and cardiovascular diseases through its antioxidative mechanisms. The effects of AST on HDL-C levels are less consistent, with some studies reporting modest increases while others show no significant changes. Similarly, the influence of AST on triglyceride levels remains inconclusive, with studies presenting mixed outcomes ranging from significant reductions to negligible effects. AST is characterized by a high safety profile and favorable bioavailability, which is influenced by its source and isomeric composition. Despite these promising findings, many existing studies are limited by small sample sizes, heterogeneous participant groups, and varied dosing regimens, which impede the ability to draw definitive conclusions. Consequently, there is a need for larger, well-standardized clinical trials to accurately assess the efficacy and safety of astaxanthin as a therapeutic agent for lipid modulation and the prevention of metabolic disorders. Future research should focus on robust methodological designs and standardized supplementation protocols to clarify AST’s role in managing dyslipidemia and enhancing cardiovascular health.
Lipedema: diagnosis, treatment and the vicious cycle - a review of the literature
Authors: Głowacka Justyna , Tekiela Natalia , Papachristoforou Natalie , Michałka Daria , Gałuszka Zuzanna , Makar Monika , Bartuś Tomasz , Bąk Emilia , Kocjan Aleksandra , Chmiel Radosław
Published: February 2025

Introduction
Lipedema is a chronic condition that affects the majority of women. It involves swelling in fatty parts of the body such as the buttocks, hips, thighs and calves. It usually develops during a period of hormonal changes (puberty, pregnancy or menopause) and is often confused with lymphoedema or obesity, leading to a delay in correct diagnosis and the introduction of effective treatment. Fat oedema is estimated to affect 1 in 72,000 people. However, these figures, according to many sources, are much underestimated compared to the actual occurrence of the condition due to misdiagnosis. [1]
Purpose of Research
The aim of this work is to commonize the knowledge around the problem of lipedema, presenting the current diagnosis and treatment.
State of knowledge
Lipaemia is a chronic disease characterised by the development of fatty oedema in the lower extremities (in some cases also in the upper extremities), which is resistant to exercise. The pathogenesis of the disease is unclear and diagnosis and treatment still require much research.
Review Methods
The literature review was based on the most recent studies. PubMed and Google Scholar open databases were used in the research. The focus was put on literature published between 2013 and 2024.
Summary
Lipedema hinders women's physical, psychological and social functioning. Current diagnosis and treatment is not sufficient to be certain of an accurate diagnosis and to apply appropriate treatment. However, knowledge about this disease is becoming more publicised, through media, among other means, and research is being conducted at a larger scale.
Teoría de grafos: una herramienta para pensar Lección Inaugural de la E.T.S. de Ingeniería de Edificación. Universidad de Sevilla. Curso Académico 2024-2025
Authors: Márquez PéreZ Alberto
Published: February 2025

La lección inaugural de Alberto Márquez Pérez, impartida en la Escuela Técnica Superior de Ingeniería de Edificación de la Universidad de Sevilla, gira en torno a la teoría de grafos como herramienta fundamental para el pensamiento en diversas disciplinas. El autor destaca que, a pesar de su simplicidad, los grafos son poderosos al permitir modelizar problemas reales de manera efectiva. Se presentan aplicaciones variadas de la teoría, subrayando su relevancia en la ingeniería de edificación. Un ejemplo motivador menciona cómo la transformación de un problema complejo en un contexto de teoría de grafos puede llevar a soluciones sorprendentes. La lección también hace hincapié en la importancia de mantener una conexión con la realidad y la humildad intelectual. A lo largo del documento, se enfatiza que la teoría de grafos va más allá de las matemáticas, siendo una herramienta valiosa en múltiples campos del conocimiento.
Trading Volume Manipulation and Competition Among Centralized Crypto Exchanges
Authors: Amiram Dan , Lyandres Evgeny , Rabetti Daniel
Published: February 2025

How competition affects manipulation by firms of information about important attributes of their products and how such information manipulation impacts firms’ short-term and long-term performance are open empirical questions. We use a setting that is especially suitable for answering these questions—centralized crypto exchanges, on which information manipulation takes the form of inflated trading volume. We find that static and dynamic competition measures are positively associated with volume inflation, indicating that competition may lead to increased information manipulation. Exchanges that manipulate volume obtain short-run benefits but are punished in the long run, consistent with the trade-off between short-lived increases in rents and future losses because of damaged reputation.

This paper was accepted by Agostino Capponi, finance.

Funding: The authors thank the Israel Science Foundation [Grant 2225/21], the Coller School of Management Blockchain Research Institute, the Henry Crown Institute for Business Research in Israel, and the Cornell Fintech Initiative for financial support.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.02903 .
O Objeto Digital de Aprendizagem webquest como uma das possibilidades de aprimoramento da prática pedagógica
Authors: De Almeida Lima Zuleick , Cláudia Lúcia Landgraf Valério Cláudia Lucia , Pereira Marcos Aparecido
Published: February 2025

As práticas pedagógicas mediadas pelo uso de tecnologias digitais e objetos digitais de aprendizagem tem intensificado discussões frequentes no meio educacional, por configurarem novas metodologias que exigem a formação de professores para o uso dos diversos recursos disponíveis ao ensino. Frente a essa questão, o objetivo da pesquisa visa discutir a importância da formação docente da área de Linguagem para o uso de tecnologias digitais e apresentar o Objeto Digital de Aprendizagem webquest como uma das possibilidades de aprimoramento da prática pedagógica, demonstrando o seu uso aplicado ao ensino na área de Linguagens. Quanto aos procedimentos metodológicos, é uma pesquisa qualitativa, básica, descritiva e exploratória, considerando as limitações, potencialidades e desafios apresentados em torno da formação docente e do uso do ODA webquest. Logo, espera-se que esse estudo ao possibilitar a investigação sobre a formação de professores para o uso Objetos Digitais de Aprendizagem como forma de compreender as lacunas sobre o assunto, sirva como fonte para pesquisas futuras, provocando reflexões sobre a importância do ODA webquest, como recurso para proporcionar maior dinamismo no ensino.
(RE)EXISTÊNCIAS CINECLUBISTAS:
Authors: Carneiro de Souza Adriana , Akemi Takeiti Beatriz , Alves Ribeiro Ana Paula
Published: February 2025

Este artigo apresenta relato de pesquisa sobre o impacto da prática coletiva na produção de subjetividades por meio da constituição e/ou afirmação de enunciados identitários em sujeitos que atuam nos cineclubes Mate com Angu, Buraco do Getúlio e Facção Feminista, localizados na Baixada Fluminense, no Rio de Janeiro. A pesquisa, de abordagem qualitativa, parte da articulação entre as noções de cultura, discurso e poder, utilizando o método cartográfico para a realização de entrevistas biográficas como ferramenta de coleta de dados. A partir da produção e análise das entrevistas, foram mapeadas três grandes categorias, sobre os quais foram realizadas análises de conteúdo: território, formação e interseccionalidade. Verificou-se que corpos marcados pela violência decorrente do preconceito de cor/raça, gênero, classe social ou território podem expandir e criar campos de existência a partir da subjetivação de experiências coletivas no campo da cultura. Observou-se que os cineclubes operam como estratégias que buscam frustrar relações de opressão, proporcionando a constituição e a reafirmação de discursos identitários, sejam estes relacionados às experiências sociais de gênero, raça/cor e/ou classe ou ao próprio território, em sujeitos que integram coletivos cineclubistas na Baixada Fluminense.
A VIOLÊNCIA CONTRA A PESSOA IDOSA
Authors: Cunha Fernanda Ielpo da , Vasconcelos José Gerardo , Nogueira Aurinete Alves
Published: February 2025

O Estatuto do Idoso se configura uma das principais leis de representação da pessoa idosa. Contudo, são muitos os estereótipos sobre a velhice que colocam em risco a integridade física e emocional da pessoa idosa, somada a exclusão social. O objetivo é analisar as principais violências praticadas contra a pessoa idosa e os impactos em suas vidas. O estudo em questão é de ordem qualitativa, com aparato descritivo analítico, através das técnicas denominadas bibliográfica e documental. Os resultados da pesquisa apontam que a violência contra a pessoa idosa é algo sociocultural sendo os maiores agressores a própria família, bem como o Estado quando não assegura os dispositivos legais. O que faz do investimento em políticas de prevenção, educação e conscientização uma peça fundamental para desconstrução dos estereótipos sobre a velhice e a garantia da proteção social da pessoa idosa.
Further Characterizing the Within-Field Variability of Watermark Soil Water Sensor Data Over Multiple Site-Years
Authors: Venishetty Vivek , Lo Tsz Him , Conger Stacia L. Davis , Rix Jacob , Yanes Buezo Robert F. , Gholson Drew M.
Published: February 2025

Highlights

Early in the season, the variability among Watermark sensor replicates increased with drying and decreased with wetting.

Later in the season, the variability among Watermark sensor replicates exhibited the opposite trend at deeper depths.

The variability among Watermark sensor replicates was generally highest at intermediate soil water status.

Preferential flow reduced the precision of irrigation scheduling using Watermark sensors.

Abstract. The adoption of granular matrix sensors to trigger irrigation has been shown to improve agricultural water management. Yet because soil moisture is variable, the use of a single sensor set per irrigation system might be detrimental to precise scheduling. The goal of this study was to assess soil water tension variation within fields in order to characterize the uncertainty of sensor-based irrigation scheduling. The study examined data from multiple Watermark 200SS sensor sets in four soybean fields that differed in soil texture and irrigation practices (rainfed or furrow irrigated). Across depths and years, the results revealed that, earlier in the growing season, variability increased during drying cycles and decreased during wetting events. The opposite tendency emerged later, where variability decreased during drying cycles and increased during wetting events. Such temporal patterns remained similar when variability was analyzed in terms of volumetric water content instead. However, peaks in variability were more pronounced, and maximum variability was observed at intermediate volumetric water content. These nuanced insights into variability dynamics will inform ongoing efforts to refine sensor-based irrigation scheduling in loams and vertisols of the Lower Mississippi River Basin. The findings and implications of this study may also inform the interpretation of soil water sensor data in similar soils beyond this region, supporting sustainable agricultural water management globally. Keywords: Irrigation, Louisiana, Mississippi, Precision, Soil moisture, Soil water tension, Uncertainty, Variability, Volumetric water content.
Development and Validation of a Protocol to Determine Feed Spillage From Commercial Broiler Feeders
Authors: Rueda Martha S. , Davis Jeremiah D. , Purswell Joseph L. , Campbell Jesse C. , Edge Carson M. , Starkey Jessica D.
Published: February 2025

Highlights

A protocol was developed to determine feed spillage from broiler pan feeders at different bird ages and feed forms.

Two validation studies (14 and 42 d) showed that excreta and wood shavings can be accounted for in live bird trials.

This protocol could be used in commercial broiler houses with only an internal screen and recover feed spillage >90%.

Abstract. Feed constitutes between 70% and 80% of total costs in commercial poultry production. As of today, it is unknown how much feed is spilled by broilers during a production flock. The objective of this project was to develop and validate a protocol to determine feed spillage from commercial broiler feeder pans. A 69 × 69 cm feed spillage capture unit consisted of a perforated top platform, internal secondary screen, and a bottom pan lined with plastic sheeting. Two experiments were conducted to simulate feed spillage rates (1%, 5%, and 10%) of broilers at 14 and 42 d of age. Feed spillage rates were applied to capture units using two internal screen approaches [no screen (NS) and secondary screen (SS)] and two corrections using an indigestible feed marker [non-corrected vs. TiO2-corrected] in a factorial arrangement. A total of 24 capture units were used to estimate recovery rates of fixed amounts of feed, wood shavings, and stone-ground mustard (as a substitute for bird excreta). Data were analyzed as a two-way ANOVA to determine interactions and main effects of screen and TiO2 correction on recovery rates. The use of a secondary screen in the capture unit aided in preventing wood shavings and simulated excreta from reaching the bottom pan. The use of TiO2 combined with the use of SS aided in segregating feed from wood shavings and simulated excreta, resulting in the best approach to determine feed spillage. When collecting feed spillage in the bottom pan using a SS followed by TiO2 correction for young birds (14 d) using crumbled feed, the percent error was within 8%, 13%, and 16% for the 1%, 5%, and 10% feed spillage rates, respectively. The larger errors for the 5% and 10% spillage rates resulted from some feed being caught by excessive wood shavings on the SS. When collecting feed spillage in the bottom pan using a SS and TiO2 correction for older birds (42 d) using pelleted feed, the percent error was within 3%, 4%, and 3% for the 1%, 5%, and 10% feed spillage rates, respectively. The proposed method can be used to accurately capture feed spillage at different broiler ages using different feed forms and to compare different commercial broiler feeders. Keywords: Broiler, Feed form, Feed spillage, Feeder.