bluuebunny/crossref_metadata_2025 huggingface dataset:
States and Measures on Hyper BCK-Algebras
Authors: Xin Xiao-Long , Wang Pu
Published: March 2014

We define the notions of Bosbach states and inf-Bosbach states on a bounded hyper BCK-algebra(H,∘,0,e)and derive some basic properties of them. We construct a quotient hyper BCK-algebra via a regular congruence relation. We also define a∘-compatibledregular congruence relationθand aθ-compatibledinf-Bosbach stateson(H,∘,0,e). By inducing an inf-Bosbach states^on the quotient structureH/[0]θ, we show thatH/[0]θis a bounded commutative BCK-algebra which is categorically equivalent to an MV-algebra. In addition, we introduce the notions of hyper measures (states/measure morphisms/state morphisms) on hyper BCK-algebras, and present a relation between hyper state-morphisms and Bosbach states. Then we construct a quotient hyper BCK-algebraH/Ker(m)by a reflexive hyper BCK-idealKer(m). Further, we prove thatH/Ker(m)is a bounded commutative BCK-algebra.
5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity
Authors: Stübig Thomas , Badbaran Anita , Luetkens Tim , Hildebrandt York , Atanackovic Djordje , Binder Thomas M. C. , Fehse Boris , Kröger Nicolaus
Published: March 2014

Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, by increasing expression of tumor-associated antigens. However, the impact of 5-Aza immune responses remains poorly understood. Here, T-cell mediated tumor immunity effects of 5-Aza, are investigatedin vitroandin vivo. T-cells from healthy donors were treated with 5-Aza and analyzed by qRT-PCR and flow cytometry for changes in gene expression and phenotype. Functionality was assessed by a tumor lysis assay. Peripheral blood from patients treated with 5-Aza after alloSCT was monitored for changes in T-cell subpopulations. 5-Aza treatment resulted in a decrease in CD8+ T-cells, whereas CD4+ T-cells increased. Furthermore, numbers of IFN-γ+ T-helper 1 cells (Th1) were reduced, while Treg-cells showed substantial increase. Additionally, CD8+ T-cells exhibited limited killing capacity against leukemic target cells.In vivodata confirm the increase of Treg compartment, while CD8+ T-effector cell numbers were reduced. 5-Aza treatment results in a shift from cytotoxic to regulatory T-cells with a functional phenotype and a major reduction in proinflammatory Th1-cells, indicating a strong inhibition of tumor-specific T-cell immunity by 5-Aza.
The Banach-Saks Properties in Orlicz-Lorentz Spaces
Authors: Kamińska Anna , Lee Han Ju
Published: March 2014

The Banach-Saks index of an Orlicz-Lorentz spaceΛφ,w(I)for both function and sequence case, is computed with respect to its Matuszewska-Orlicz indices ofφ. It is also shown that an Orlicz-Lorentz function space has weak Banach-Saks (resp., Banach-Saks) property if and only if it is separable (resp., reflexive).
An Audit of Operating Room Time Utilization in a Teaching Hospital: Is There a Place for Improvement?
Authors: Stavrou George , Panidis Stavros , Tsouskas John , Tsaousi Georgia , Kotzampassi Katerina
Published: March 2014

Aim. To perform a thorough and step-by-step assessment of operating room (OR) time utilization, with a view to assess the efficacy of our practice and to identify areas of further improvement. Materials and Methods. We retrospectively analyzed the most ordinary general surgery procedures, in terms of five intervals of OR time utilization: anaesthesia induction, surgery preparation, duration of operation, recovery from anaesthesia, and transfer to postanaesthesia care unit (PACU) or intensive care unit (ICU). According to their surgical impact, the procedures were defined as minor, moderate, and major. Results. A total of 548 operations were analyzed. The mean (SD) time in minutes for anaesthesia induction was 19 (9), for surgery preparation 13 (8), for surgery 115 (64), for recovery from anaesthesia 12 (8), and for transfer to PACU/ICU 12 (9). The time spent in each step presented an ascending escalation pattern proportional to the surgical impact P=0.000, which was less pronounced in the transfer to PACU/ICU P=0.006. Conclusions. Albeit, our study was conducted in a teaching hospital, the recorded time estimates ranged within acceptable limits. Efficient OR time usage and outliers elimination could be accomplished by a better organized transfer personnel service, greater availability of anaesthesia providers, and interdisciplinary collaboration.
Robust Adaptive Fault-Tolerant Control of Stochastic Systems with Modeling Uncertainties and Actuator Failures
Authors: Cai Wenchuan , Fan Lingling , Song Yongduan
Published: March 2014

This paper deals with the problem of fault-tolerant control (FTC) of uncertain stochastic systems subject to modeling uncertainties and actuator failures. A robust adaptive fault-tolerant controller design method based on stochastic Lyapunov theory is developed to accommodate the negative impact on system performance arising from uncertain system parameters and external disturbances as well as actuation faults. There is no need for on-line fault detection and diagnosis (FDD) unit in the proposed FTC scheme, which not only simplifies the design process but also makes the implementation inexpensive. Numerical examples are provided to validate and illustrate the benefits of the proposed control method.
An Improved VFF Approach for Robot Path Planning in Unknown and Dynamic Environments
Authors: Ni Jianjun , Wu Wenbo , Shen Jinrong , Fan Xinnan
Published: March 2014

Robot path planning in unknown and dynamic environments is one of the hot topics in the field of robot control. The virtual force field (VFF) is an efficient path planning method for robot. However, there are some shortcomings of the traditional VFF based methods, such as the local minimum problem and the higher computational complexity, in dealing with the dynamic obstacle avoidance. In this paper, an improved VFF approach is proposed for the real‐time robot path planning, where the environment is unknown and changing. An area ratio parameter is introduced into the proposed VFF based approach, where the size of the robot and obstacles are considered. Furthermore, a fuzzy control module is added, to deal with the problem of obstacle avoidance in dynamic environments, by adjusting the rotation angle of the robot. Finally, some simulation experiments are carried out to validate and demonstrate the efficiency of the proposed approach.
Modified Block Pulse Functions for Numerical Solution of Stochastic Volterra Integral Equations
Authors: Maleknejad K. , Khodabin M. , Hosseini Shekarabi F.
Published: March 2014

We present a new technique for solving numerically stochastic Volterra integral equation based on modified block pulse functions. It declares that the rate of convergence of the presented method is faster than the method based on block pulse functions. Efficiency of this method and good degree of accuracy are confirmed by a numerical example.
Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study
Authors: Selli Cesare , Bjartell Anders , Burgos Javier , Somerville Matthew , Palacios Juan-Manuel , Benjamin Laure , Black Libby , Castro Ramiro
Published: March 2014

Objective. To assess the impact of low-to-moderate risk prostate cancer on patients’ quality of life (QoL) at diagnosis and within the first year of treatment.Subjects and Methods. Men (n=672) aged 50–75 years with prostate cancer (Gleason score≤7, PSA≤20 ng/mL and clinical staging T1c–T2b) were enrolled in five European countries. Patients completed five questionnaires, including EORTC Quality of Life Questionnaire—Prostate Cancer 25 (QLQ-PR25) and EORTC Quality of Life Questionnaire—Cancer 30 (QLQ-C30). Questionnaires were completed at baseline, at 3 months and 12 months after starting treatment. The primary endpoint was the change in QLQ-PR25 urinary symptoms subscale score from baseline to the assessment at 3 months.Results. Mean (SD) age was 65.0 (5.7) years and 400 (66%) men had Gleason score ≤6 prostate cancer. The most frequently used initial treatment was radical prostatectomy (71% of patients). QLQ-PR25 urinary symptoms subscale score was significantly increased at 3 months (P<0.001), indicating that urinary symptoms worsened after treatment. The score was lower at 12 months than at 3 months, but it was still significantly higher than at baseline (P<0.001). Hormonal treatment-related symptoms, sexual functioning, and sexual activity scores significantly worsened at 3 and 12 months (allP<0.001). For the QLQ-C30 questionnaire, global health status/QoL score significantly decreased at month 3 but was not different from baseline by month 12. Scales for physical, role, and social functioning, and fatigue, showed significant deterioration at 3 and 12 months.Conclusions. Low-to-moderate risk prostate cancer may have a substantial effect on patients’ QoL within one year following treatment.
Statistical Inference for Stochastic Differential Equations with Small Noises
Authors: Shen Liang , Xu Qingsong
Published: March 2014

This paper proposes the least squares method to estimate the drift parameter for the stochastic differential equations driven by small noises, which is more general than pure jumpα-stable noises. The asymptotic property of this least squares estimator is studied under some regularity conditions. The asymptotic distribution of the estimator is shown to be the convolution of a stable distribution and a normal distribution, which is completely different from the classical cases.
IL-21 Receptor Expression in Human Tendinopathy
Authors: Campbell Abigail L. , Smith Nicola C. , Reilly James H. , Kerr Shauna C. , Leach William J. , Fazzi Umberto G. , Rooney Brian P. , Murrell George A. C. , Millar Neal L.
Published: March 2014

The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level. The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β)in vitro. These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages. Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy.
A Study on Instantaneous Time-Frequency Methods for Damage Detection of Nonlinear Moment-Resisting Frames
Authors: Darvishan Ehsan , Ghodrati Amiri Gholamreza , Ghaderi Pedram
Published: March 2014

Most of the civil structures exhibit nonlinear hysteresis behavior during earthquakes. However, detection of damage in these structures is a challenging issue due to successive change in structural characteristics during a seismic excitation. The current paper presents a promising approach for damage detection of nonlinear moment frames. First, several instantaneous time-frequency methods including Hilbert-Huang transform, direct quadrature, Teager energy operator, and higher-order energy operator are investigated as signal processing tools and the most appropriate method is selected using an outlier analysis. Next, a procedure is proposed based on time-frequency analysis in conjunction with clustering to find damage extension in moment frames under a seismic excitation using frequency, amplitude, and energy damage measures. A probabilistic approach is implemented to investigate capability of the procedure for different ground motion records using incremental dynamic analysis. Results show that frequency is not an appropriate feature to detect damage in nonlinear structures.
Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats
Authors: Yue Gui-Hua , Zhuo Shao-Yuan , Xia Meng , Zhang Zhuo , Gao Yi-Wen , Luo Yuan
Published: March 2014

Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats. Methods. A rat model of spontaneous hypertension was used. The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChip(GC) analysis using the Agilent Whole Rat Genome Oligo Microarray. Results. Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group. Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated. GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death. Conclusion. Hypertension altered expression of many genes that regulate various biological functions. HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats. These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca(2+) homeostasis, and NO pathway. This study provides the potential novel insights into hypertension and antihypertension effects of HJD.
An Iterative Algorithm for the Split Equality and Multiple-Sets Split Equality Problem
Authors: Shi Luoyi , Chen Ru Dong , Wu Yu Jing
Published: March 2014

The multiple-sets split equality problem (MSSEP) requires finding a pointx∈∩i=1NCi,y∈∩j=1MQjsuch thatAx=By, whereNandMare positive integers,{C1,C2,…,CN}and{Q1,Q2,…,QM}are closed convex subsets of Hilbert spacesH1,H2, respectively, andA:H1→H3,B:H2→H3are two bounded linear operators. WhenN=M=1, the MSSEP is called the split equality problem (SEP). If  B=I, then the MSSEP and SEP reduce to the well-known multiple-sets split feasibility problem (MSSFP) and split feasibility problem (SFP), respectively. One of the purposes of this paper is to introduce an iterative algorithm to solve the SEP and MSSEP in the framework of infinite-dimensional Hilbert spaces under some more mild conditions for the iterative coefficient.
Biomechanical Analysis of the Efficacy of Locking Plates during Cyclic Loading in Metacarpal Fractures
Authors: Doht Stefanie , Meffert Rainer H. , Raschke Michael J. , Blunk Torsten , Ochman Sabine
Published: March 2014

Purpose.To analyse the biomechanical characteristics of locking plates under cyclic loading compared to a nonlocking plate in a diaphyseal metacarpal fracture.Methods.Oblique diaphyseal shaft fractures in porcine metacarpal bones were created in a biomechanical fracture model. An anatomical reduction and stabilization with a nonlocking and a comparable locking plate in mono- or bicortical screw fixation followed. Under cyclic loading, the displacement, and in subsequent load-to-failure tests, the maximum load and stiffness were measured.Results.For the monocortical screw fixation of the locking plate, a similar displacement, maximum load, and stiffness could be demonstrated compared to the bicortical screw fixation of the nonlocking plate.Conclusions.Locking plates in monocortical configuration may function as a useful alternative to the currently common treatment with bicortical fixations. Thereby, irritation of the flexor tendons would be avoided without compromising the stability, thus enabling the necessary early functional rehabilitation.
The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2Synthase
Authors: Asif Mohammad
Published: March 2014

The pyridazine moiety is an important structural feature of various pharmacological active compounds. Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is, inhibitors of prostaglandin or cyclooxygenase (COX-I & COX-II) enzyme, platelet cAMP phosphodiesterase, and thromboxane A2 (TXA2) synthase. These compounds are selective and nonselective COX inhibitors and showed analgesic, anti-inflammatory, and antipyretic activity. Pyridazine compounds with antiplatelet agents inhibited TXA2enzyme. Pyridazines also exhibited antirheumatoid activity. These pyridazine compounds hold considerable interest relative to the preparation of organic intermediates and other anticipated biologically active compounds.
Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis
Authors: Fernandes Jamille Souza , Araujo Maria Ilma , Lopes Diego Mota , Souza Robson da Paixão de , Carvalho Edgar M. , Cardoso Luciana Santos
Published: March 2014

A major issue withSchistosoma mansoniinfection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++). The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-βwas higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R) between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.
A RE-Based Double Measurement Method for Unknown Rotor Profile of Screw Compressor
Authors: Ji Xiao-Gang , Yang Yan , Xue Jie , He Xue-Ming
Published: March 2014

An accurate and efficient measurement for unknown rotor profile of screw compressor has been a nodus in the field of coordinate measuring machine (CMM) measurement because of its complexity of 3D helical surface, whose normal vectors vary with different measured points, while conventional 2D measuring methods have the inevitable radius compensation. If measured points and corresponding normal vectors are known, a 3D radius compensation then could be applied without a theoretical error. In this paper, a double-measurement method based on Reverse Engineering (RE) is proposed to solve this problem. The first measurement focused on constructing a 3D CAD model as accurate as possible. So, according to the structure characteristics of the unknown rotor, a reasonable WCS is established firstly. Then a DRCH method is presented to eliminate the outliers of measured points. Finally, an indirect method is presented to measure the screw pitch with projection and transformation of measured point sets. In second section, a 3D measurement is planned by DIMS language with setting measured points and corresponding normal vectors, which are calculated according to 3D CAD model constructed in first section. Final experimental analysis indicates that measuring accuracy with this double-measurement method is improved greatly.
Reinforced Feedback in Virtual Environment for Rehabilitation of Upper Extremity Dysfunction after Stroke: Preliminary Data from a Randomized Controlled Trial
Authors: Kiper Paweł , Agostini Michela , Luque-Moreno Carlos , Tonin Paolo , Turolla Andrea
Published: March 2014

Objectives. To study whether the reinforced feedback in virtual environment (RFVE) is more effective than traditional rehabilitation (TR) for the treatment of upper limb motor function after stroke, regardless of stroke etiology (i.e., ischemic, hemorrhagic).Design. Randomized controlled trial.Participants. Forty-four patients affected by stroke.Intervention. The patients were randomized into two groups: RFVE (N=23) and TR (N=21), and stratified according to stroke etiology. The RFVE treatment consisted of multidirectional exercises providing augmented feedback provided by virtual reality, while in the TR treatment the same exercises were provided without augmented feedbacks.Outcome Measures. Fugl-Meyer upper extremity scale (F-M UE), Functional Independence Measure scale (FIM), and kinematics parameters (speed, time, and peak).Results. The F-M UE (P=0.030), FIM (P=0.021), time (P=0.008), and peak (P=0.018), were significantly higher in the RFVE group after treatment, but not speed (P=0.140). The patients affected by hemorrhagic stroke significantly improved FIM (P=0.031), time (P=0.011), and peak (P=0.020) after treatment, whereas the patients affected by ischemic stroke improved significantly only speed (P=0.005) when treated by RFVE.Conclusion. These results indicated that some poststroke patients may benefit from RFVE program for the recovery of upper limb motor function. This trial is registered withNCT01955291.
Rosiglitazone Regulates Anti-Inflammation and Growth Inhibition via PTEN
Authors: Lin Chiou-Feng , Young Kung-Chia , Bai Chyi-Huey , Yu Bu-Chin , Ma Ching-Ting , Chien Yu-Chieh , Chiang Chiu-Ling , Liao Chao-Sheng , Lai Hsin-Wen , Tsao Chiung-Wen
Published: March 2014

Peroxisome proliferator-activated receptor gamma (PPARγ) agonist has anti-inflammatory and anticancer properties. However, the mechanisms by which PPARγagonist rosiglitazone interferes with inflammation and cancer via phosphatase and tensin homolog-(PTEN)-dependent pathway remain unclear. We found that lower doses (<25 μM) of rosiglitazone significantly inhibited lipopolysaccharide-(LPS)-induced nitric oxide (NO) release (via inducible nitric oxide synthase, iNOS), prostaglandin E2 (PGE2) production (via cyclooxygenase-2, COX-2), and activation of Akt in RAW 264.7 murine macrophages. However, rosiglitazone did not inhibit the production of reactive oxygen species (ROS). In PTEN knockdown (shPTEN) cells exposed to LPS, rosiglitazone did not inhibit NO release, PGE2production, and activation of Akt. These cells had elevated basal levels of iNOS, COX-2, and ROS. However, higher doses (25–100 μM) of rosiglitazone, without LPS stimulation, did not block NO release and PGE2productions, but they inhibited p38 MAPK phosphorylation and blocked ROS generation in shPTEN cells. In addition, rosiglitazone caused G1 arrest and reduced the number of cells in S + G2/M phase, leading to growth inhibition. These results indicate that the anti-inflammatory property of rosiglitazone is related to regulation of PTEN independent of inhibition on ROS production. However, rosiglitazone affected the dependence of PTEN-deficient cell growth on ROS.
Recurrent Bilateral Occipital Infarct with Cortical Blindness and Anton Syndrome
Authors: Kwong Yew Kiu , Abdul halim Sanihah , Liza-Sharmini Ahmad Tajudin , Tharakan John
Published: March 2014

Bilateral cortical blindness and Anton syndrome, are most commonly caused by ischaemic stroke. In this condition, patients have loss of vision but deny their blindness despite objective evidence of visual loss. We report a case of a patient with multiple cardiovascular risk factors who developed recurrent bilateral occipital lobe infarct with Anton syndrome. A suspicion of this condition should be raised when the patient has denial of blindness in the presence of clinical and radiological evidence of occipital lobe injury. Management of this condition should focus on the underlying cause, in which our patient requires secondary stroke prevention and rehabilitation.
Metalloprotease Dependent Release of Placenta Derived Fractalkine
Authors: Siwetz Monika , Blaschitz Astrid , Kremshofer Julia , Bilic Jelena , Desoye Gernot , Huppertz Berthold , Gauster Martin
Published: March 2014

The chemokine fractalkine is considered as unique since it exists both as membrane-bound adhesion molecule and as shed soluble chemoattractant. Here the hypothesis was tested whether placental fractalkine can be shed and released into the maternal circulation. Immunohistochemical staining of human first trimester and term placenta sections localized fractalkine at the apical microvillous plasma membrane of the syncytiotrophoblast. Gene expression analysis revealed abundant upregulation in placental fractalkine at term, compared to first trimester. Fractalkine expression and release were detected in the trophoblast cell line BeWo, in primary term trophoblasts and placental explants. Incubation of BeWo cells and placental explants with metalloprotease inhibitor Batimastat inhibited the release of soluble fractalkine and at the same time increased the membrane-bound form. These results demonstrate that human placenta is a source for fractalkine, which is expressed in the syncytiotrophoblast and can be released into the maternal circulation by constitutive metalloprotease dependent shedding. Increased expression and release of placental fractalkine may contribute to low grade systemic inflammatory responses in third trimester of normal pregnancy. Aberrant placental metalloprotease activity may not only affect the release of placenta derived fractalkine but may at the same time affect the abundance of the membrane-bound form of the chemokine.
Abnormal Early Gamma Responses to Emotional Faces Differentiate Unipolar from Bipolar Disorder Patients
Authors: Liu T. Y. , Chen Y. S. , Su T. P. , Hsieh J. C. , Chen L. F.
Published: March 2014

This study investigates the cortical abnormalities of early emotion perception in patients with major depressive disorder (MDD) and bipolar disorder (BD) using gamma oscillations. Twenty-three MDD patients, twenty-five BD patients, and twenty-four normal controls were enrolled and their event-related magnetoencephalographic responses were recorded during implicit emotional tasks. Our results demonstrated abnormal gamma activity within 100 ms in the emotion-related regions (amygdala, orbitofrontal (OFC) cortex, anterior insula (AI), and superior temporal pole) in the MDD patients, suggesting that these patients may have dysfunctions or negativity biases in perceptual binding of emotional features at very early stage. Decreased left superior medial frontal cortex (smFC) responses to happy faces in the MDD patients were correlated with their serious level of depression symptoms, indicating that decreased smFC activity perhaps underlies irregular positive emotion processing in depressed patients. In the BD patients, we showed abnormal activation in visual regions (inferior/middle occipital and middle temporal cortices) which responded to emotional faces within 100 ms, supporting that the BD patients may hyperactively respond to emotional features in perceptual binding. The discriminant function of gamma activation in the left smFC, right medial OFC, right AI/inferior OFC, and the right precentral cortex accurately classified 89.6% of patients as unipolar/bipolar disorders.
Regret Theory and Equilibrium Asset Prices
Authors: Sheng Jiliang , Wang Jian , Yang Jun
Published: March 2014

Regret theory is a behavioral approach to decision making under uncertainty. In this paper we assume that there are two representative investors in a frictionless market, a representative active investor who selects his optimal portfolio based on regret theory and a representative passive investor who invests only in the benchmark portfolio. In a partial equilibrium setting, the objective of the representative active investor is modeled as minimization of the regret about final wealth relative to the benchmark portfolio. In equilibrium this optimal strategy gives rise to a behavioral asset priciting model. We show that the market beta and the benchmark beta that is related to the investor’s regret are the determinants of equilibrium asset prices. We also extend our model to a market with multibenchmark portfolios. Empirical tests using stock price data from Shanghai Stock Exchange show strong support to the asset pricing model based on regret theory.
Disturbances of Sperm Maturation and Minipuberty: Is There a Connection?
Authors: Živković D. , Fratrić I.
Published: March 2014

Male reproductive function in the general population raises an increased attention due to reports indicating declining sperm counts, increased occurrence of testicular cancer, cryptorchidism, and hypospadias. It is also hypothesized that prolonged exposure of the developing male, during both fetal and postnatal life, to exogenous estrogens could reduce Sertoli cell number and thus reduce sperm output (and sperm counts) in adult life. Fact is that infertility, which is defined as the inability to conceive after 1 year of unprotected intercourse, has a global prevalence of 9%. A male contributory factor is involved in approximately half of these cases, but most of the causes of reduced semen quality and other disturbances of male reproductive function are unknown. In the most affected men (azoospermic men) 15–20% had a prior history of cryptorchidism. The association between the cryptorchidism and infertility is one of the most studied potential causes of infertility. There are numerous studies that accentuate the importance of minipuberty for future fertility. Is it possible that a normal minipuberty ensures normal fertility despite malpositioned testes? And to move away from cryptorchidism, could impaired minipuberty be responsible for fertility problems in men who were born with both testes in their scrotal sacs?
A Case-Control Study on Risk Factors for Preterm Deliveries in a Secondary Care Hospital, Southern India
Authors: Rao Chythra R. , de Ruiter Lara E. E. , Bhat Parvati , Kamath Veena , Kamath Asha , Bhat Vinod
Published: March 2014

Introduction. Preterm birth is the leading cause of newborn deaths and the second leading cause of death in children under five years old. Three-quarters of them could be saved with current, cost-effective interventions. The aim of this study was to identify the risk factors of preterm birth in a secondary care hospital in Southern India. Methods. In the case-control study, records of 153 antenatal women with preterm birth were included as cases. Age matched controls were women who had a live birth after 37 weeks of gestational age. Gestational age at delivery and associated risk factors were analyzed. Results. The preterm birth rate was 5.8%. Common risk factors associated with preterm birth were hypertensive disorders of pregnancy (21.4%), height <1.50 m (16.8%), premature rupture of membranes (17.5%), and fetal distress (14.9%). Mean birth weight for preterm babies was 2452 grams while the birth weight for term babies was 2978 grams. Conclusion. The commonest obstetrical risk factor for preterm birth was hypertensive disorders of pregnancy and nonobstetrical risk factor was height <1.50 m. The percentage of preterm birth was low, comparable to developing countries.
One Single Amino Acid for Estimation the Content of Total Free Amino Acids inQingkailing InjectionUsing High-Performance Liquid Chromatography-Diode Array Detection
Authors: Zhang Li , Wang Xue , Su Jiankun , Liu Haiyu , Zhang Zhixin , Qin Lingling , He Cheng , Peng Long , Guo Mingxing , Gao Xiaoyan
Published: March 2014

Qingkailing injection (QKLI), a modern traditional Chinese medicine preparation, has been widely used in clinics due to its fast and significant efficacy in treatment of high fever. The free amino acids (AAs) were considered to be the most abundant active ingredients indisputably. So developing an accurate and simple determination method to measure the contents of total free AAs inQKLIis very crucial. In current study, the accurate and simple method of using one single standard AA for simultaneous quantification of multiple AAs (One for M) inQKLIwas developed. Particularly, the calculation methods and the robustness of relative correction factors (RCFs) were investigated systematically. No statistically significant difference between these two quantification methods of One for M and classic regression equation was found by thet-test (P  =  95%,P>0.05). The results showed that the precision (RSD < 4.88%), the robustness (RSD < 4.04%), and the average recoveries (94.11%–107.94%) of this newly proposed method all met the requirements for content determination. This One for M method will provide a scientific reference for the quantitative determination of AAs in other traditional Chinese medicines and their preparations owing to its accuracy and simplicity.
Some Remarks on the Mathieu Series
Authors: Frontczak Robert
Published: March 2014

The object of this note is to present new expressions for the classical Mathieu series in terms of hyperbolic functions. The derivation is based on elementary arguments concerning the integral representation of the series. The results are used afterwards to prove, among others, a new relationship between the Mathieu series and its alternating companion. A recursion formula for the Mathieu series is also presented. As a byproduct, some closed-form evaluations of integrals involving hyperbolic functions are inferred.
Standard-Tract Combined with Mini-Tract in Percutaneous Nephrolithotomy for Renal Staghorn Calculi
Authors: Wang Yanbo , Hou Yuchuan , Jiang Fengming , Wang Yan , Chen Qihui , Lu Zhihua , Hu Jinghai , Wang Xiaoqing , Lu Ji , Wang Chunxi
Published: March 2014

Purpose: To compare the safety and efficacy of standard-tract combined with mini-tract to single standard-tract in percutaneous nephrolithotomy (PCNL) for renal staghorn calculi. Methods: The records of 216 patients with staghorn calculi (110 (50.9%) had complete and 106 (49.1%) had partial) who received PCNL were reviewed retrospectively. 58 patients received standard-tract combined with mini-tract PCNL (group A) and 158 patients underwent single standard-tract PCNL (group B). Both groups had comparable demographic data. Operation time, stone-free rate, blood transfusion rate, hospital stay and complications were analyzed. Results: Postoperative Clavien score in the two groups was similar. The rate of blood transfusion and perioperative bleeding requiring superselective embolization were not statistically significant between the groups (p = 0.557, 0.463, respectively). The mean operation time was comparable between groups in the standard-tract combined with mini-tract group. The stone-free rate was significantly higher (89.7 vs. 78.5%, p = 0.044) in group A than in group B. The rate of second PCNL was higher in group B. Conclusion: The standard-tract combined with mini-tract results had higher success rates with no increase in the incidence of complications, and should be the first option for renal staghorn calculi.
Pediatric Neurosurgery Patients Need More than a Neurological Surgeon: A Clinical Experience
Authors: James Hector E. , MacGregor Teresa L. , Childers Jr. David O. , La Corte Emanuele , Aldana Philipp R.
Published: March 2014

The Division of Pediatric Neurosurgery of the University of Florida College of Medicine Jacksonville initiated and developed a multidisciplinary comprehensive team for the management of patients with a neurosurgical condition other than spina bifida. This report relates the rationale and stages of development of a multidisciplinary team to facilitate the health care and special needs of these children.
Exploring the Morphological and Functional Retinal Changes after Dexamethasone Intravitreal Implant (Ozurdex®) in Macular Edema due to Retinal Vein Occlusion
Authors: Parravano Mariacristina , Oddone Francesco , Boccassini Barbara , Giorno Paola , Chiaravalloti Adele , Tedeschi Massimiliano , Scarinci Fabio , Varano Monica
Published: March 2014

Purpose: To explore functional and morphological retinal changes 6 months after dexamethasone intravitreal implant (DEX implant) for the treatment of macular edema due to central or branch retinal vein occlusion (CRVO, BRVO). Procedures: In this prospective interventional case series patients underwent a complete ophthalmological examination at baseline and monthly, including best-corrected visual acuity (BCVA), spectral domain-optical coherence tomography and microperimetry. Fluorescein angiography was performed at baseline and at 4 months. All patients were treated with a DEX implant and retreated according to predefined criteria starting from month 4. Results: Sixteen patients (mean age 66 ± 13 years, 14 CRVO, 2 BRVO) were included. At 6 months mean retinal sensitivity improved from 9.7 ± 4.6 to 13.6 ± 5.4 dB (p < 0.0001) while mean BCVA improved from 52.4 ± 16.2 to 66.1 ± 16.6 (p < 0.0001). Mean central retinal thickness decreased from 708.3 ± 151.01 to 362.7 ± 177.4 μm (p < 0.0001); 56.2% of eyes were retreated at month 4. Conclusions: At 6 months DEX implant led to a significant improvement in retinal sensitivity and visual acuity associated with a reduction of retinal thickness in patients with macular edema due to retinal vein occlusion.
The Concentration-Dependent Effects of Indocyanine Green on Retinal Function in the Electrophysiological ex vivo Model of Isolated Perfused Vertebrate Retina
Authors: Ranjbar Mahdy , Alt Aizhan , Nassar Khaled , Reinsberg Mihaela , Schneider Toni , Grisanti Salvatore , Lüke Julia , Lüke Matthias
Published: March 2014

Background: Dye solutions such as indocyanine green (ICG) are used for the staining of intraocular structures. The aim of the presented study was to investigate the effects of ICG on bovine retinal function using different concentrations of ICG. Methods: Bovine retina preparations were perfused with a standard solution and the electroretinogram was recorded. The nutrient solution was substituted by an ICG solution at varying concentrations for 45 min. Afterwards the preparations were reperfused with standard solution for at least 85 min. Results: Significant reductions in b-wave amplitude were found for concentrations of 0.0025% (p = 0.0099) and 0.025% (p = 0.0378). For the concentration of 0.025%, the b-wave amplitude remained significantly decreased (p = 0.0082) after the observation period, but a full recovery of the b-wave was observed for the concentration of 0.0025% (p = 0.1917). Conclusion: Intraocular application of sufficient ICG concentrations for internal limiting membrane staining seems not possible without interfering with retinal function.
Proust, Neurology and Stendhal's Syndrome
Authors: Teive Hélio A.G. , Munhoz Renato P. , Cardoso Francisco
Published: March 2014

Marcel Proust is one of the most important French writers of the 20th century. His relationship with medicine and with neurology is possibly linked to the fact that his asthma was considered to be a psychosomatic disease classified as neurasthenia. Stendhal's syndrome is a rare psychiatric syndrome characterized by anxiety and affective and thought disturbances when a person is exposed to a work of art. Here, the authors describe neurological aspects of Proust's work, particularly the occurrence of Stendhal's syndrome and syncope when he as well as one of the characters of In Search of Lost Time see Vermeer's View of Delft during a visit to a museum.
Brain Implants for Substituting Lost Motor Function: State of the Art and Potential Impact on the Lives of Motor-Impaired Seniors
Authors: Ramsey N.F. , Aarnoutse E.J. , Vansteensel M.J.
Published: March 2014

Recent scientific achievements bring the concept of neural prosthetics for reinstating lost motor function closer to medical application. Current research involves severely paralyzed people under the age of 65, but implications for seniors with stroke or trauma-induced impairments are clearly on the horizon. Demographic changes will lead to a shortage of personnel to care for an increasing population of senior citizens, threatening maintenance of an acceptable level of care and urging ways for people to live longer at their home independent from personal assistance. This is particularly challenging when people suffer from disabilities such as partial paralysis after stroke or trauma, where daily personal assistance is required. For some of these people, neural prosthetics can reinstate some lost motor function and/or lost communication, thereby increasing independence and possibly quality of life. In this viewpoint article, we present the state of the art in decoding brain activity in the service of brain-computer interfacing. Although some noninvasive applications produce good results, we focus on brain implants that benefit from better quality brain signals. Fully implantable neural prostheses for home use are not available yet, but clinical trials are being prepared. More sophisticated systems are expected to follow in the years to come, with capabilities of interest for less severe paralysis. Eventually the combination of smart robotics and brain implants is expected to enable people to interact well enough with their environment to live an independent life in spite of motor disabilities.
High Serum Ferritin Levels Increase the Risk of Hyperuricemia: A Cross-Sectional and Longitudinal Study
Authors: Zhang Ya-nan , Xu Chengfu , Xu Lei , Yu Chaohui , Miao Min , Xie Jianhong , Li Youming
Published: March 2014

Background/Aims: To examine the cross-sectional and longitudinal associations of serum ferritin levels with hyperuricemia. Methods: A cross-sectional and subsequently prospective study was performed among the employees of Zhenhai Refining and Chemical Company, Ningbo, China. In a cross-sectional study, the association between serum ferritin levels and the prevalence of hyperuricemia was analyzed. Subjects who were free of hyperuricemia at baseline were followed up annually to explore the prospective association between serum ferritin levels and hyperuricemia incidence. Results: Of the 10,074 subjects enrolled at baseline, 1,731 (17.18%) fulfilled the diagnostic criteria of hyperuricemia. Subjects with hyperuricemia presented significantly higher serum ferritin levels, and the levels were positively correlated with the prevalence of hyperuricemia. During a total of 22,367 person-years of follow-up, 502 subjects developed hyperuricemia. The overall incidence of hyperuricemia for 1,000 person-years of follow-up was 22.4, ranging from 17.6 in subjects with baseline serum ferritin levels in the first quintile to 19.2, 21.7, 23.9, and 30.7 in subjects in quintiles 2, 3, 4, and 5, respectively (p for trend < 0.001). Cox regression analyses showed that serum ferritin levels were positively associated with the risk of incident hyperuricemia. Conclusions: Our cross-sectional and longitudinal results indicate that high serum ferritin levels increase the risk of hyperuricemia.
Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women
Authors: Li Shuang , Ou Yangna , Zhang Hongbing , Zhang Zhimin , Zhou Houde , Liu Lihong , Sheng Zhifeng , Liao Eryuan
Published: March 2014

Aims: This study was designed to assess vitamin D (25(OH)D) status and its relationship with bone mineral density (BMD) and fracture risk, which was determined using the FRAX algorithm, among postmenopausal central south Chinese women, and to identify the risk factors for vitamin D deficiency and osteoporosis. Methods: This cross-sectional study involved 578 healthy postmenopausal central south Chinese women. Fat mass and BMD at lumbar spine (L1-L4), femur neck and total hip were measured with dual X-ray absorptiometry. Serum levels of 25(OH)D, parathyroid hormone and creatinine were measured. The 10-year probabilities of hip and major osteoporotic fracture were calculated by the FRAX model. Results: Approximately 72.1% women were vitamin D deficient (25(OH)D <50 nmol/l). Serum 25(OH)D levels did not correlate with body mass index (BMI), fat mass and weight. They positively correlated with all BMDs (p < 0.05) and negatively correlated with both 10-year fracture probabilities (p < 0.05). BMI ≤19 and age ≥65 years were risk factors for osteoporosis at all sites. Conclusions: Vitamin D deficiency was prevalent among postmenopausal central south Chinese women. Serum 25(OH)D levels were correlated with all BMDs and negatively correlated with both 10-year fracture probabilities.
Coenzyme Q10 Therapy
Authors: Garrido-Maraver Juan , Cordero Mario D. , Oropesa-Ávila Manuel , Fernández Vega Alejandro , de la Mata Mario , Delgado Pavón Ana , de Miguel Manuel , Pérez Calero Carmen , Villanueva Paz Marina , Cotán David , Sánchez-Alcázar José A.
Published: March 2014

For a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ10. Also, at the inner mitochondrial membrane level, CoQ10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ10 levels as well as different ataxias and encephalomyopathies. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.
Long-Term Remission of an Aggressive Sebaceous Carcinoma following Chemotherapy
Authors: Orcurto Angela , Gay Béatrice E. , Jeanneret Sozzi Wendy , Gilliet Michel , Leyvraz Serge
Published: March 2014

Sebaceous carcinoma (SC) is an uncommon neoplasm manifesting itself either in the eyelid or extraocularly in the head and neck area. Surgery is the standard of care. Irradiation is rarely proposed as monotherapy but is frequently administered as an adjuvant regimen following surgical resection. There is no known strategy concerning chemotherapeutic treatment in highly aggressive recurrent - or metastatic - forms of the disease. Our patient presented with an aggressive SC of the scalp recurring after multiple excisions and local radiotherapy. Chemotherapy with 5-fluorouracil, cisplatin and docetaxel was then initiated; 4 cycles were administered, followed by capecitabine maintenance. Shortly after starting chemotherapy, dermal lesions had completely disappeared and radiological response could be seen. The patient experienced an extended period (>20 months) of complete remission. In this report, we show an excellent response of a highly aggressive SC after a combination of chemotherapy as for head and neck cancers.