bluuebunny/crossref_metadata_2025 huggingface dataset:
Stochastic Modeling of Solar Generation During Hurricanes
Authors: Ceferino Luis , Lin Ning , Xi Dazhi
Published: August 2021

The unprecedented growth of solar generation adoption indicates that solar can become a major source of modern and clean energy in just a few decades for our power grids. Despite solar's growing criticality for generation, few studies have proposed models to capture solar generation infrastructure's behavior during natural disasters. Here, we present an integrative methodology to quantify solar generation during hurricanes. The methodology is based on a stochastic model that combines a tropical cyclone hazard model, solar irradiance quantification, solar panel vulnerability, and a model for irradiance decay during hurricane conditions. The irradiance decay model is newly developed through mixed-effect regression on a dataset that merges historical Global Horizontal Irradiance and Atlantic hurricane activity. The proposed stochastic model can be integrated into large grid resilience's models for a wide range of detailed applications that require forecasting power system capacity during storms, such as contingency planning for extreme events. We use the stochastic model to analyze 21 states in the Eastern U.S. for various storms to showcase the methodology's broad applicability. Our results show that for events with return periods of up to 33 years, the loss in generation stems from cloud conditions during hurricanes. However, less frequent events can cause solar panel failure, especially in southern regions of the U.S., triggering complete loss of solar generation. Given that solar generation is expected to grow significantly, these results advocate for higher standards in the structural design of solar panels as well as the deployment of storage for disaster resilience.
HSPB7 Protected the Osteogenic Differentiation of Mesenchymal Stem Cells From TNF-α Through Chaperone-mediated Autophagy/beta-catenin Pathway
Authors: Hang Kai , Ying Li , Bai Jinwu , Wang Yibo , Kuang Zhihui , Xu Jianx , Zhou Chenw , Xue Deting , Pan Zhijun
Published: August 2021

Background Managing healing of impaired bone fracture has long been a subject of concern. Prolonged or uncontrolled inflammation exerts detrimental effects on bone healing. Tumor necrosis factor (TNF)-α is a critical inflammatory factor, whose absence impairs normal bone formation. However, TNF-α exposure for longer duration inhibits bone regeneration. In this study, we aim to find a new therapeutic target for the impaired osteogenesis induced by long exposure of TNF-α.MethodsIn vitro, mRNA microarray analysis was used to identify differentially expressed genes. Cell proliferation assay was used to assess the proliferation of cells. qPCR and Western blotting analysis were applied to detect the expression of target genes and proteins respectively. ALP staining and Alizarin Red staining (ARS) were used to evaluate ALP activity and mineral deposition respectively. Co-immunoprecipitation was used to detect the interaction of proteins. In vivo, a murie tibial fracture model was established, histological evaluation and radiographic analysis was used to confirm bone regeneration in fracture healing. statistical significance between two groups was determined by Student’s t test, one-way ANOVA or Bonferroni’s post-hoc test according to the distribution of the tested population.ResultsIn this study, we show that heat shock protein family B (small) member 7 (HSPB7) mitigates negative impact of long-term TNF-α exposure on bone formation by binding heat shock protein family H (small) member 1 (HSPH1). HSPH1, in turn, inhibits the ATPase of heat shock cognate A8 (HSCA8), one of the key components involved in chaperone-mediated autophagy (CMA). Deletion of genes encoding for either HSCA8 or lysosome-associated membrane protein 2A (LAMP2A), another component of CMA, failed to reverse the osteogenic differentiation of hBMSCs induced by TNF-α by deleting HSPH1. Moreover, LAMP2A overexpression reverse the impaired osteogenesis induced by TNF-α, and this effect was attenuated by DKK1, a specific Wnt/β-catenin signaling pathway inhibitors. Thus, a heat shock protein family network composed by HAPB7, HSPH1 and HSCA8 rescued the impairment of bone healing by TNF-α through the CMA/β-catenin pathway, making it a potential therapeutic agent for bone regeneration in cases of prolonged or severe inflammation in the clinical settings. ConclusionsTaken together, these findings indicate that a heat shock protein family network including HSPB7, HSPH1 and HSCA8 protects the impaired osteogenesis induced by TNF-α via the CMA/β-catenin pathway. And in vivo, HSPB7 overexpression lentiviral particles effectively protects the impaired fracture healing induced by TNF-α in a mouse tibia fracture healing model.
Association Between Habitual Green Tea Consumption and Comprehensive Frailty Risk Assessed by Kihon Checklist Indexes Among Japanese Elderly Population
Authors: Nanri Hinako , Yoshida Tsukasa , Watanabe Yuya , Fujita Hiroyuki , Kimura Misaka , Yamada Yosuke
Published: August 2021

Background: It is unclear whether habitual green tea consumption is related to comprehensive frailty. Objective: We conducted this study to investigate this relationship among a Japanese elderly population.Methods: This was a cross-sectional study of baseline data from 2012. The study included 5668 Japanese participants (2766 men and 2902 women, aged 65 years or older). The subjects completed a validated self-administered food frequency questionnaire that included green tea consumption. We evaluated comprehensive frailty by using a 25-item Kihon Checklist (KCL), which comprised seven domains (instrumental activities of daily living [IADL], physical function, malnutrition, oral or eating function, socialization and housebound, cognitive function, and depression). Frailty was defined as a KCL score ≥7. Results: We found that higher consumption of green tea was associated with a lower risk of frailty in both sexes. Further age-stratified analysis showed that higher consumption of green tea among women was associated with a lower risk of frailty, regardless of age. In men, however, these associations were found only in the older age groups. An analysis of the association between green tea consumption and frailty subdomains showed that green tea consumption was associated with a lower risk of oral dysfunction and cognitive problem in both sexes. In addition, only in women, higher green tea consumption was inversely associated with a lower risk of IADL and mobility-related disability problems.Conclusions: Green tea consumption is inversely associated with the prevalence of comprehensive frailty in Japanese men and women. Longitudinal studies are required to confirm this association.
Mouth Washes – A Paradigm Shift from Chlorhexidine Gluconate to Essential Oil Mouthwash A Meta Analysis
Authors: Hussain
Published: August 2021

Background: The purpose of this review is to systematically evaluate the effects of an essential-oil mouthwash compared to a chlorhexidine mouthwash with respect to plaque and parameters of gingival inflammation.Methods: PubMed databases were searched for studies up to and including may 2015. A comprehensive search was designed and the articles were independently screened. Articles that evaluated the effects of the essential oil mouthwash compared to chlorhexidine mouthwash were included. A meta-analysis was performed, and weighted mean differences were calculated.Results: A total of 17 unique articles were found, of which 11 articles met the eligibility criteria. A meta-analysis of long-term studies (duration > 3 months) showed that the essential oil mouthwash provided significantly better effects regarding prophylactic plaque control than chlorhexidineConclusion: In long-term use, the standardized formulation of essential oil mouthwash is more reliable than chlorhexidine mouthwash.
Enantioselective Behavior of Flumequine Enantiomers and Metabolites Identification in Sediment
Authors: Xue Moyong , Qin Yuchang , Meng Qingshi , Yao Ting , Gu Xu
Published: August 2021

The enantioselective adsorption, degradation and transformation of flumequine (FLU) enantiomers in sediment were investigated to elucidate the enantioselective environmental behaviors. The results of adsorption test showed stereoselective differences of FLU enantiomers in sediment samples and the adsorbing capacity of S-(-)-FLU and R-(+)-FLU are higher than the racemate, the pH values of the sediment determined the adsorption capacity. Enantioselective degradation behaviors were found under non-sterilized conditions and followed pseudo-first-order kinetic. The R-(+)-FLU was preferentially degraded, and there was significant enantioselectivity of the degradation of FLU. It can be concluded that the microorganism was the main reason for the stereoselective degradation in sediments. The physicochemical property of sediments, such as pH value and organic matter content, can affected the degradation rate of FLU. In addition, the process of transformation of FLU enantiomers in water-sediment system had enantioselective behavior, R-(+)-FLU was preferential transformed. Meanwhile, the main metabolites of FLU in sediment were decarboxylate and dihydroxylation product. This study contributes evidence of comprehensively assessing the fate and risk of chiral FLU antibiotic and enantioselective behavior in the environment.
IVF Outcome Comparisons Between Fresh Embryo Transfers and Embryo Banking Cycles With Subsequent Thawed Transfers Vary Between Good-, Intermediate- and Poor-prognosis Patients
Authors: Gleicher Norbert , Darmon Sarah K. , Molinari Emanuela , Albertini David F. , Benor Ariel , Patrizio Pasquale , Barad David H.
Published: August 2021

Never investigated before in poor prognosis patients, we here determined how in vitro fertilization (IVF) outcomes after fresh embryo transfers compare to frozen-thawed transfers after embryo banking. Using data from our center’s anonymized electronic research data bank, we in a retrospective controlled observational study investigated IVF cycle outcomes of poor-prognosis infertility patients, utilizing autologous eggs, while utilizing donor-egg recipient cycles as controls for covariables. To accomplish statistically valid comparisons, 4 different pairings of 1st IVF cycles were utilized: (i) 127 fresh vs. 193 frozen donor recipient cycles; (ii) 741 autologous fresh unselected non-donor IVF cycles vs. 217 autologous frozen non-donor IVF cycles; (iii) 143 favorably selected autologous non-donor IVF cycles vs. the same 217 frozen autologous cycles non-donor; and (iv) 598 selected average and poor-prognosis autologous non-donor cycles vs. the same 217 frozen autologous non-donor cycles. Main outcome measures were pregnancies and live births. Even within poor-prognosis patients, patient selection to significant degrees impacted how fresh and frozen-thawed IVF cycles compared. Though embryo banking with delayed embryo transfer in best-prognosis patients marginally improved IVF outcomes, in unselected patients it had no effect on outcomes, while in poor-prognosis patients it adversely affected IVF outcomes. Unexpectedly, the study also discovered a previously unreported effect of recipient-age on miscarriage risk in donor-egg recipient cycles, which apparently is independent of age-associated increases in chromosomal abnormalities and, therefore, must have other causes. This study suggests that in poor-prognosis patient banking cycles should be considered contraindicated, in intermediate-prognosis patients they do not appear to change outcomes and, therefore, do not warrant additional costs from thaw cycles, leaving only good-prognosis patients as potential candidates for such a strategy.
Spatiotemporal Distribution and Evolution of Digestive Tract Cancer Cases in Hefei, China Since 2012
Authors: Ma Kang , Lin Yuesheng , Zhang Xiaopeng , Fang Fengman , Zhang Yong , Li Jiajia , Yao Youru , Ge Lei , Zhou Hao , Wu Jing , Chen Hui
Published: August 2021

Background: Cancer has become the major killer of deaths among Chinese urban and rural residents, and about 50% of new cases are from liver cancer, gastric cancer, and esophageal cancer. Digestive tract cancer(DTC) has received widespread attention due to its poor treatment effect and high mortality rate, as well as severe physical, psychological, mental, and economic trauma to patients and their families.Methods: The data on DTC cases in Lujiang County in Hefei, China, were downloaded from the Data Center of the Center for Disease Control and Prevention in Hefei, Anhui Province, China, while the demographic data were sourced from the demographic department in China. Systematic statistical analyses, including the spatial empirical Bayes smoothing, spatial autocorrelation, hotspot statistics, and Kulldorff's retrospective space-time scan, were used to identify the spatial and spatiotemporal clusters of DTC. GM(1,1) and standard deviation ellipses were then applied to predict the future evolution of the spatial pattern of the DTC cases in Lujiang County. Results: DTC in Lujiang County had obvious spatiotemporal clustering. The spatial distribution of DTC cases increases gradually from east to west in the county in a stepwise pattern. The peak of DTC cases occurred in 2012-2013, and the high-case spatial clusters were located mainly in the northwest of Lujiang County. At the 1% significance level, two spatiotemporal clusters were identified. From 2012 to 2017, the cases of DTC in Lujiang County gradually shifted to the high-incidence area in the northwest, and the spatial distribution range experienced a process of “dispersion-clustering”. The cases of DTC in Lujiang County will continue to move to the northwest from 2018 to 2025, and the predicted spatial clustering tends to be more obvious. Conclusions: High-incidence time of DTC was 2012-2013, and the number of cases increased from east to west in Lujiang County. High clusters were mostly located in the northwestern area and agglomerated from southeast to northwestern especially after 2014.
Relationship of Matrix Stiffness and Cell Morphology in Regulation of Osteo Genesis and Adipogenesis of BMSCs
Authors: Guo Yutong , Qiao Yini , Quan Shuqi , Yang Cai , Li Juan
Published: August 2021

Backgrounds: Both matrix stiffness and cell morphology have been found as important factors directing MSCs (mesenchymal stem cells) differentiation, but cells also spontaneously adapt their morphology under matrix stiffness stimulation. This study aimed to investigate the interplay of cell morphology and matrix stiffness on osteogenesis and adipogenesis of rBMSCs(rat bone BMSCs) on 2D substrates. Methods and Results: First, we modulated MSCs morphology through different fibronectin (FN) concentrations on tissue culture plates (TCPs). We found FN promoted and osteogenesis of BMSCs while suppressing adipogenesis, mediated by FN-induced F-actin polymerization and cell spreading. Based on these findings, we modulated BMSCs morphology on 0.5 kPa and 32 kPa CytoSoft® plates through FN concentrations. We found BMSCs on 0.5 kPa substrates coated with 300μg/ml of FN manifested similarly spreading morphology with cells on 32 kPa substrates coated with 100 μg/ml of FN, and cells in both groups dominantly commit osteogenesis. On the other hand, BMSCs on 32 kPa substrates coated with 30μg/ml of FN manifested similarly restricted morphology with cells in on 0.5 kPa substrates with 100μg/ml of FN, and in both groups cells mainly commit adipogenesis. Immunofluorescence staining indicated YAP/TAZ mainly located in cytoplasm when cells exhibited restricted morphology on stiff matrices, while exhibiting significant nuclear translocation when cells spread on soft matrices. Conclusions: Cell morphology overrode effects of matrix stiffness on BMSCs differentiation through more robust regulation of YAP/TAZ. Matrix stiffness depended on cell morphology to regulate osteogenesis and adipogenesis of BMSCs.
Comparing the Efficacy of Dermolina-Henna Cream with Mometasone Cream in Improving Radiodermatitis Amongst Patients with Breast Cancer: A Randomized Active-control Double-blind Clinical Trial
Authors: Pasalar Mehdi , Ahadi Bahareh , Mirzaei Hamid Reza , Buentzel Judith , Ardestani Mojgan Mehri , Kamian Shaghayegh , Heydarirad Ghazaleh
Published: August 2021

Purpose: Acute radiodermatitis is one of radiotherapy most common complications. Despite the high prevalence of radiodermatitis, few studies investigated how to prevent or treat this complication. Hence, any standard treatment has not been introduced so far. We sought to evaluate the efficacy of Dermolina-Henna cream, a new polyherbal formulation, compared to Mometasone cream for alleviating radiodermatitis amongst breast cancer patients. Methods: Women over 18 years of age with breast cancer undergoing radiotherapy were included in this double-blind active-control randomized clinical trial. A total of 93 eligible patients was randomly divided into the Dermolina-Henna and Mometasone groups. Patients were instructed to apply a thin layer of each cream once daily on their lesions at least 3 hours after radiotherapy for 4 weeks, and if grade I or II radiodermatitis developed, also afterward. Patients were visited weekly until end of study at after 4 weeks. RTOG (Radiation Therapy Oncology Group) standard questionnaires were evaluated and recorded every week as the primary outcome.Results: The trends on decrease in number of lesions, erythema, radiodermatitis grade, burning sensation, pain, and itchiness were statistically significant for each treatment, separately (P<0.001), except for radiodermatitis grade in Mometasone group (P=0.4). Dermolina-Henna was significantly better than Mometasone in alleviating burning sensation (P<0.001) and itchiness (P=0.041).Conclusion: In summary, we showed that Dermolina-Henna cream and Mometasone cream were significantly effective in decreasing severity of radiodermatitis symptoms amongst patients with breast cancer. Dermolina-Henna cream was significantly superior to Mometasone cream in alleviating burning and itchiness. IRCT20200115046144N1, 2020-03-04, retrospectively registered.
How good is good? Probabilistic benchmarks and nanofinance+
Authors: Martinez Rolando Gonzales
Published: August 2021

Benchmarks are standards that allow to identify opportunities for improvement among comparable units. This study suggests a 2-step methodology for calculating probabilistic benchmarks in noisy data sets: (i) double-hyperbolic undersampling filters the noise of key performance indicators (KPIs), and (ii) a relevance vector machine estimates probabilistic benchmarks with denoised KPIs. The usefulness of the methods is illustrated with an application to a database of nano-finance+. The results indicate that---in the case of nano-finance groups---a higher discrimination power is obtained with variables that capture the macro-economic environment of the country where a group operates. Also, the estimates show that groups operating in rural regions have different probabilistic benchmarks, compared to groups in urban and peri-urban areas.
Phage Tail-like Nanostructures Affect Microbial Interactions between Streptomyces and Fungi
Authors: Nagakubo Toshiki , Yamamoto Tatsuya , Asamizu Shumpei , Toyofuku Masanori , Nomura Nobuhiko , Onaka Hiroyasu
Published: August 2021

Extracellular contractile injection systems (eCISs) are structurally similar to headless phages and are versatile nanomachines conserved among diverse classes of bacteria. Herein, Streptomyces species, which comprise filamentous Gram-positive bacteria and are ubiquitous in soil, were shown to produce Streptomyces phage tail-like particles (SLPs) from eCIS-related genes that are widely conserved among Streptomyces species. In some Streptomyces species, these eCIS-related genes are regulated by a key regulatory gene, which is essential for Streptomyces life cycle and is involved in morphological differentiation and antibiotic production. Deletion mutants of S. lividans of the eCIS-related genes appeared phenotypically normal in terms of morphological differentiation and antibiotic production, suggesting that SLPs are involved in other aspects of Streptomyces life cycle. Using co-culture method, we found that colonies of SLP-deficient mutants of S. lividans were more severely invaded by fungi, including Saccharomyces cerevisiae and Schizosaccharomyces pombe. In addition, microscopic and transcriptional analyses demonstrated that SLP expression was elevated upon co-culture with S. pombe. In contrast, co-culture with Bacillus subtilis markedly decreased SLP expression and increased antibiotic production. Our findings demonstrate that in Streptomyces, eCIS-related genes affect microbial competition, and the patterns of SLP expression can differ depending on the competitor species.
Necrosis on Pre-treatment 18F-FDG PET/CT Predicts Worse Prognosis in Patients With Stage IIIB Non-small Cell Lung Cancer.
Authors: Eren Gülnihan , Kupik Osman
Published: August 2021

ObjectiveThe presence of pathological necrosis in the tumor is known to be a factor indicating worse survival. Our study aimed to define necrosis in staging 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with stage IIIB non-small-cell lung cancer (NSCLC) to investigate whether this is a poor prognostic marker. Methodology﻿To evaluate necrosis on 18F FDG PET/CT, we drew a region of interest (ROI) in the area showing visually very low/or no FDG uptake on PET and PET/CT fusion images. If SUVmax was less than blood pool SUVmax and showed significantly less attenuation [10 to 30 Hounsfield Units (HU)] than surrounding tissue on low-dose correlative CT with non-intravenous contrast, we defined it as necrotic (PETNECROSIS). We evaluated the relationship of SUVmax, tumor size, and PETNECROSIS with Progression-free survival (PFS) using a cox proportional hazard regression model.ResultsPFS analysis was performed in 16 patients treated with standard chemoradiotherapy (CRT) regimen. Tumor size ≤ 42mm vs > 42mm (p = 0.044, HR: 6.103, 95CI%: 1.053–35.358) and PETNECROSİS presence/absence (p = 0.027, HR: 6.719, 95CI%: 1.245–36.264) were independent predictors for PFS. Patients with tumor size ≤ 42mm and PETNECROSİS absence were associated with higher 1-year PFS rate than patients with tumor size > 42mm and PETNECROSİS presence (86% vs 63.5% p = 0.005 and 87.5% vs 29%, p = 0.001 respectively).ConclusionPETNECROSİS is helpful to distinguish patients who would suffer worse survival in stage IIIB NSCLC.
A Novel Graphene Modelling: Bottom up Approach - Band Gap Studies to Transport in Python
Authors: Bhardwaj Bhavya , B Bala Tripura Sundari
Published: August 2021

In this work we develop a computational, quantum level monolayer graphene nanoribbon (GNR) MOSFET of channel length of 10 and 20 nm, with a width of 2 nm and contacts of 2nm width is attached. To develop the MOSFET channel, a bottom up approach is adopted by developing the material model. First the material models of graphene nanoribbon is developed using pybinding module tool in python. The material models of monolayer, bilayer graphene nanoribbon are built on the principles of tight binding module. The methodology developed is based on the Hamiltonian matrix formulation that has been used to determine the E-k plots and LDOS plots of graphene monolayer, bilayer graphene nano ribbon. The GNR MOSFET that is structurally built in python is used to simulate graphene as a switch. Its band gap characteristics is presented as its performance as a switch and is verified with relevant work. Then GNR MOSFET is modelled using quantum principles of NEGF and greens function to determine the transmission characteristics and the I-V characteristics for channel lengths of 10 nm and 20 nm.
De Sitter entropy as holographic entanglement entropy
Authors: Tetradis Nikolaos
Published: August 2021

We review the results of refs. [1,2], in which
the entanglement entropy in spaces with horizons, such as Rindler or de
Sitter
space, is computed using holography. This is achieved through an appropriate
slicing of anti-de Sitter space and the implementation of a UV cutoff.
When the entangling surface coincides with the horizon of the boundary
metric,
the entanglement entropy can be identified with the standard gravitational
entropy of the space. For this to hold, the effective Newton's constant must
be defined appropriately by absorbing the UV cutoff. Conversely, the UV
cutoff
can be expressed in terms of the effective Planck mass and the number of
degrees of freedom of the dual theory. For de Sitter space, the entropy is
equal to the Wald entropy for an effective action that includes the
higher-curvature terms associated with the conformal anomaly. The
entanglement
entropy takes the expected form of the de Sitter entropy, including
logarithmic corrections.
Charges in the extended BMS algebra: Definitions and applications
Authors: Porrati Massimo
Published: August 2021

This is a review of selected topics from recent work on symmetry
charges in asymptotically flat spacetime done by the author in
collaboration with U. Kol and R. Javadinezhad. First we reinterpret the
reality constraint on the boundary graviton as the gauge fixing of a new
local symmetry, called dual supertranslations. This symmetry extends the
BMS group and bears many similarities to the dual (magnetic) gauge
symmetry of electrodynamics. We use this new gauge symmetry to propose a
new description of the TAUB-NUT space that does not contain closed
time-like curves. Next we summarize progress towards the definition of
Lorentz and super-Lorentz charges that commute with supertranslations
and with the soft graviton mode.
Superradiant instability and black resonators in AdS
Authors: Ishii Takaaki
Published: August 2021

Rapidly rotating Myers-Perry-AdS black holes are unstable against
rotational superradiance. From the onset of the instability,
cohomogeneity-1 black resonators are constructed in five-dimensional
asymptotically AdS space. By using the cohomogeneity-1 metric,
perturbations of the cohomogeneity-1 black resonators are also
studied.
Position-dependent mass quantum systems and ADM formalism
Authors: Momeni Davood
Published: August 2021

The classical Einstein-Hilbert (EH) action for general relativity
(GR) is shown to be formally analogous to the classical system with
position-dependent mass (PDM) models. The analogy is developed and used
to build the covariant classical Hamiltonian as well as defining an
alternative phase portrait for GR. The set of associated Hamilton’s
equations in the phase space is presented as a first-order system dual
to the Einstein field equations. Following the principles of quantum
mechanics, I build a canonical theory for the classical general. A fully
consistent quantum Hamiltonian for GR is constructed based on adopting a
high dimensional phase space. It is observed that the functional wave
equation is timeless. As a direct application, I present an alternative
wave equation for quantum cosmology. In comparison to the standard
Arnowitt-Deser-Misner(ADM) decomposition and quantum gravity proposals,
I extended my analysis beyond the covariant regime when the metric is
decomposed into the 3+13+1
dimensional ADM decomposition. I showed that an equal dimensional phase
space can be obtained if one applies ADM decomposed metric.
Ecotourism Potential Zone Mapping by Using Analytic Hierarchy Process (AHP) and Weighted Linear Algorithm: A Study on West Bengal, India
Authors: Raha Shrinwantu , Mondal Madhumita , Gayen Shasanka Kumar
Published: August 2021

This study was designed to demarcate the Ecotourism Potential Zones (ETPZs) of West Bengal using the Analytic Hierarchy Process (AHP) and weighted linear algorithm by considering three sustainable tourism parameters and sixteen indicators. Those three parameters are 1) physical (P), 2) social (S), and 3) availability of scenic beauty and infrastructures (ASI). Overall, 5 parameters are merged under physical (P), 2 parameters are integrated under social (S), and 9 parameters are incorporated under availability of scenic beauty and infrastructures (ASI). A 4-step procedure has been adopted for this study: 1) a simple hierarchical structure has been outlined, 2) pair-wise comparison matrices are formed, 3) weighted linear algorithm technique is utilized to get the ecotourism potentiality zone, and 4) ecotourism potentiality map is classified into high, moderate and low categories based on the principle of Dominant and Distinctive Function (DDF). As a result, about 61.65% area is identified with high ecotourism potential zone, 17.86% area is observed under the moderate ecotourism potential zone, and 20.48% area is recognized as the low ecotourism potential zone. Thus, the study considers an exceptional methodological framework that is applicable in any region of the world.
Presentación
Authors: Navarro Mariano
Published: August 2021

Hoy, felizmente, damos a la estampa y al ciberespacio -los dos medios de difusión de nuestra revista- una nueva entrega, la cuarta, con la misma ilusión y entusiasmo con que la Escuela de Comunicación inició hace tres años una aventura intelectual. Ilusión y entusiasmo que son dos virtudes universitarias que emanan de la vocación investigadora y que, a su vez, animan al estudioso para vencer los obstáculos que se interponen en el camino de la búsqueda de la verdad como lugar de llegada donde se ubican las soluciones a los problemas científicos. Hoy, como digo, debemos sentir cierta satisfacción por este nuevo logro que significa una aportación a la problemática de los estudios de la comunicación en las universidades. Por ello, deseo destacar y reafirmar la buena marcha de la revista plasmada en el presente número gracias a los esfuerzos de los Dres. López Yepes y López Aguirre y sin olvidar el papel tan esencial que han desempeñado algunos de los miembros del Consejo científico y del Consejo editorial de nuestra revista en labores de evaluación de los numerosos artículos que hemos recibido.
Doña Marina y la india Catalina. Vidas paralelas con Hernán Cortés y Pedro de Heredia
Authors: López Yepes José
Published: August 2021

Estudio comparativo de dos mujeres indias históricas y legendarias: Doña Marina (Malinche), que acompañó a Hernán Cortés en la colonización de México y la india Catalina asimismo pareja de Pedro de Heredia, fundador de la ciudad de Cartagena de Indias. Ambas han generado numerosos documentos en todos los soportes: texto, audio, iconografía, literatura, video, etc. En este artículo se presentan algunos contenidos de todo ello y se trata de observar el gran paralelismo que anida en ambas vidas. Este artículo, en el ámbito de lo que entendemos por lectura crítica, ofrece muchas posibilidades para el conocimiento de los personales y de los contextos históricos y legendarios de los mismos así como un instrumento de aprendizaje en la investigación para los estudiantes universitarios. La base de reflexión lo constituyen dos series televisivas de ficción histórica.
Experimental study on cavity pressure of carbon dioxide fracturing tube
Authors: Zeng Yongqing , Li Haibo , Xia Xiang , Deng Shouchun , Wu Renjie , Liu Xiaohong
Published: August 2021

The peak pressure and duration of high-pressure gas in the process of rock breaking by carbon dioxide fracturing will have a great impact on the fracturing effect of rock mass. For the sake of obtaining dynamic pressure response characteristic in the fracturing tube, the pressure-time curve of liquid CO2 blasting system was measured through several cavity pressure test of carbon dioxide fracturing tube. The cavity pressure test under different parameters of carbon dioxide quantity, activator quantity and thickness of energy release plate is carried out, in which TST6200 transient signal acquisition instrument, 109c12 type blasting shock wave sensor and special signal processing software system are used. The relation curve between pressure and time in the liquid CO2 fracturing tube was effectively measured and the variation law of pressure curve was analyzed. The results show that after igniting the liquid carbon dioxide fracturing tube, the cavity pressure rise slowly, then increases sharply and decays rapidly, when the pressure reaches the yield pressure limit of energy release plate, the energy release plate will be destroyed and high pressure gas will be released rapidly; the peak pressure in the CO2 fracturing system ranges from 169.1 MPa to 260.2 MPa, the duration of positive pressure is from 21.1 ms to 74.8 ms, and the peak pressure arrival time is between 13.2 ms and 67.7 ms. This paper attempts to establish the formula relationship between peak cavity pressure and thickness of energy release plate for carbon dioxide fracturing tube; the welded flat head formula, tensile failure formula and shear failure formula are used to calculate peak cavity pressure of carbon dioxide fracturing tube, in which the calculated results are compared with the measured values, the welded flat head formula severely underestimates the peak cavity pressure; conversely, the tensile failure formula slightly overestimated the peak cavity pressure; the shear failure formula can accurately reflect the peak cavity pressure of fracturing tube. The conclusions can be directly used for the design and optimization of fracturing tube by using different thickness energy release plate to control the cavity pressure of carbon dioxide fracturing tube.
How the Triple-Helix Model of Innovation is changing the Indian COVID-19 Fight?
Authors: Ray Samrat
Published: August 2021

It is indeed a great misnomer to analyze the dimensions of academic capitalism with the steady rise of entrepreneurial university in line with Western educational policies. It has been a long journey in emerging underdeveloped economies has given the dream of the next superpower where entrepreneurial universities are a very recent concept of post-liberal economy, change in governmental practices and bureaucratic affairs. This has led to a stronger innovation landscape of industry-education-government nexus in building the nation. Recent years have seen the great crisis of COVID-19 pandemic which has changed the ideologies and theoretical models underlying economically well-off states and the velocity of money circulation. Amidst the huge amount of literature in entrepreneurial university studies, very little work has been done which answers the very pertinent question and covers the research gap. Namely, how the Triple Helix model arrived in India and how the central government in India dramatically changed its beliefs by inheriting such a model in its innovation practices. The model that championed the cause of bringing about new products, economic welfare and product development. These transformed India's idea of being an importer of healthcare facilities to becoming an expert and exporter of medical facilities, thus completely reversing the cycle of trade and global logistics in healthcare economic practices. This paper works on such an exploratory case study concerning India's success story in employing triple helix model of innovation in national policy practices and world economy.
PROPOSTA INVESTIGATIVA PARA O ESTUDO DAS RELAÇÕES TRIGONOMÉTRICAS UTILIZANDO O SOFTWARE GEOGEBRA
Authors: Barbosa Miquéias Rodrigues , Pereira Kézia Cristiane de Mendonça , Nóbrega Luciano Xavier Gomes da , Braz Ricardo Antônio Faustino da Silva
Published: August 2021

Neste artigo, foram analisados os resultados oriundos de uma aula inédita, onde foi utilizado o software GeoGebra como recurso tecnológico e cuja utilização teve o propósito de auxiliar na construção de conceitos matemáticos. A referida aula ocorreu em uma escola estadual no município de Natal/RN em uma turma da 2ª série do ensino médio composta por 24 alunos. A aula inédita foi desenvolvida a partir de uma sequência didática investigativa. Os assuntos abordados nessa aula foram relações trigonométricas: seno, cosseno e tangente. Esse tema se apresenta como conteúdo matemático bastante útil na resolução de problemas do cotidiano e no exercício de algumas atividades profissionais. A escolha pelo software GeoGebra se deu pelo fato de que ele permite construções precisas e adequadas ao conteúdo de trigonometria. Os dados observados, indicam melhoria na participação dos estudantes nas atividades desenvolvidas, justificando assim, o uso de tecnologias digitais no Ensino da Matemática.
Ensino de história: metodologias ativas e aprendizagem significativa
Authors: Silva Maria Lúcia Alves Teixeira
Published: August 2021

A proposta desse estudo vai além do debate acerca da metodologia tradicionalista, aponta possíveis alternativas que possibilite trazer o aluno para dimensão histórica considerando a experiência da história por ele vivida. Como situação-problema indaga-se: que resultados se podem obter com o ensino da disciplina de História com a práxis de novos paradigmas estimuladores do ensino-aprendizagem? Os objetivos estão em compreender o processo de práticas libertadoras quanto aos hábitos de ler, interpretar e ser capaz de dar novos significados às produções históricas num hábito de se fazer crítica às nomenclaturas textuais. É preciso abandonar os “velhos” sistemas/costumes e “navegar” pelos “novos” caminhos que a literatura moderna tem para oferecer. A metodologia/técnica pauta-se pela pesquisa bibliográfica/exploratória com uso de material disponível em sites na busca de informações para contextualização. Verificou-se a potencialidade do ensino centrado no aluno, e o quanto as metodologias ativas contribuem para a aprendizagem significativa.
Covid-19 ve Medyada Dijitalleşme Etkisi: Ana Haber Bültenlerinde Sağlık Haberleri, Whatsapp İhbar Hattı ve Online Röportaj Kullanımı Üzerine Bir İnceleme
Authors: Kaya İlhan Çağla , Büyükçelikok Türkan Öykü
Published: August 2021

Araştırma kapsamında, covid 19 pandemisinin ana haber bültenlerindeki haber seçim, oluşum ve sunum sürecine etkileri ele alınmıştır. Bu amaçla, pandemi döneminde; sağlık kategorindeki haberlerin ana haber bültenleri içerisinde yer alma sıklığı ve televizyon haberciliği alanındaki dijital dönüşümler, whatsapp ihbar hatları ve online ropörtaj tekniklerinin kullanım yoğunluğunun artışı çerçevesinde incelenmiştir. Çalışmada, Covid-19 pandemisinin sağlık haber kategorisinin ana haber bültenlerinde yer alma oranı ve yarattığı dijitalleşme etkisinin incelenmesinde içerik analizi yöntemi kullanılmıştır. Bu kapsamda reyting oranlarına göre seçilen Fox TV, Show TV ve ATV televizyon kanallarının ana haber bültenlerinde 2020 ve 2021 yıllarının Ocak ayının ilk haftalarında yer alan ve günlük yayınlanan toplam haber sayıları, sağlık haberleri sayıları, Whatsapp ihbar hattının kullanımı ve stüdyodan yapılan online röportajların ana haber bülteni içeriklerinde yer alma durumuyla ilgili bulgular incelenmiştir. Çalışmanın sonucunda, sağlık haberlerindeki ve ele alınan dijital uygulamalar aracılığıyla oluşturulan haber sayılarındaki artış ile pandeminin ana haber bültenlerine etkisi ortaya konulmuştur.
Zengin Okul Çevresi, Büyük Öz Kaynak: Okul Aile Birliği Gelirlerinin Okul Çevresinin Sosyoekonomik Düzeyine Göre İncelenmesi
Authors: Özkan Metin , Karakurt Neytullah , Yaşar İlyas
Published: August 2021

Devlet okulları büyük oranda kamusal kaynaklarla finanse edilmekle birlikte okul aile birliği gelirleriyle öz gelir yaratma ihtiyacı duymaktadırlar. Öz gelirler okulların özellikle cari harcamalarının karşılanmasında önemli bir yer tutabilmektedir. Ancak okulların öz gelirlerinin okul bölgesinin sosyoekonomik düzeyine göre farklılaşması eğitimde sosyal adaletsizliğe kaynaklık edebilir. Bu araştırmanın amacı okul aile birliği gelirlerinin okulun hizmet alanı sınıflandırmasına göre farklılık gösterip göstermediğinin belirlenmesidir. Araştırmada büyükşehir kapsamındaki merkez iki ilçenin ilk, orta ve liselerinin tamamının okul aile birliği gelirleri ile hizmet alanı sınıflandırması veri kaynağı olarak kullanılmıştır. Hizmet alanı bölgesine göre zorunlu hizmet bölgesi kapsamındaki okullarla, diğer okullar arasındaki öğrenci başına okul aile birliği gelirleri karşılaştırılmıştır. İlk ve orta okul düzeyinde her iki ilçede de zorunlu hizmet bölgesi aleyhine öğrenci başı okul aile birliği gelirlerinin anlamlı bir şekilde farklılaştığı görülmüştür. Lise düzeyinde ise ilçenin birinde fark anlamlı bulunmazken, diğerinde yine zorunlu hizmet bölgesi aleyhine fark bulunmuştur.
Recent Advancements in Green Synthesis of Nanoparticles for Improvement of Bioactivities: A Review
Authors: Punetha Vinay Deep , Dhali Sunil , Rana Anita , Karki Neha , Tiwari Himani , Negi Pushpa , Basak Souvik , Sahoo Nanda Gopal
Published: August 2021

:

Natural products have widely been used in applications ranging from antibacterial, antiviral, antifungal, and various other medicinal applications. The use of these natural products was recognized way before the establishment of basic chemistry behind the disease and the chemistry of plant metabo-lites. After the establishment of plant chemistry, various new horizons evolved, and the application of natural products breached the orthodox limitations. In one such interdisciplinary area, the use of plant materials in the synthesis of nanoparticles (NPs) has exponentially emerged. This advancement has offered various environment-friendly methods where hazardous chemicals are completely replaced by natural products in the sophisticated and hectic synthesis processes. This review is an attempt to under-stand the mechanism of metal nanoparticlessynthesis using plant materials. It includes details on the role of the plant’s secondary metabolites in the synthesis of nanoparticles including the mechanism of action. In addition, the use of these nanomaterials has widely been discussed along with the possible mechanism behind their antimicrobial and catalytic action.
Zinc 1,2,4-triazolo[1,5-a]pyrimidine Complexes: Synthesis, Structural
Characterization and their Effect Against Chagas Disease
Authors: Méndez-Arriaga José M. , Rubio-Mirallas Erika , Quirós Miguel , Sánchez-Moreno Manuel
Published: August 2021

Background:

The World Health Organization catalogues illnesses such as Chagas disease
as neglected diseases, due to the low investment in new drugs to fight them. The search for novel and
non-side effects anti-parasitic compounds is one of the urgent needs of the Third World. The use of
triazolopyrimidines and their metal complexes have demonstrated hopeful results in this field.

Objective:

This work studies the antiparasitic efficacy against Trypanosoma cruzi strains of a series
of zinc triazolopyrimidine complexes.

Method:

A series of Zn complexes has been synthesized by the reaction between the triazolopyrimidine
derivatives 7-amino-1,2,4-triazolo[1,5-a]pyrimidine (7atp) and 5,7-dimethyl-1,2,4-triazolo[1,5-
a]pyrimidine (dmtp) with Zn(SO4) · 7H2O, ZnCl2, and Zn(NO3)2 · 6H2O salts. The complexes have
been analyzed by spectroscopic and thermal assays and X-ray diffraction methods have been used to
dilucidate the crystalline structure of one of them. The antiparasitic efficacy was tested in vitro
against Trypanosoma cruzi to compare the trypanocidal effect of different ligands and counteranions
to fight Chagas disease.

Results:

The efficacy of these compounds against Trypanosoma cruzi has also been tested to compare
the influence of different ligands and counteranions on the trypanocidal effect against Chagas
disease.

Conclusion:

Antiproliferative tests corroborate the synergistic trypanocidal effect of the triazolopyrimidine
coordination complexes.
Challenges and Progress in Vaccine Development for COVID-19 Coronavirus (SARS-CoV-2): A Review
Authors: Moharir Keshav S. , Arora Sumit K. , Yende Subhash R. , Lohiya Govind K. , Shah Sapan K.
Published: August 2021

Coronavirus Infectious Disease (COVID-19) has taken heavy toll on human lives and world economy across the globe. Till date, there is no specific treatment and pathological effects in COVID-19 are continuously evolving. The governments and authorities have announced various measures for personal care with use of face masks, physical distancing and prohibition of mass gatherings. These measures have certainly helped to contain the disease but with substantial economic slowdown. Thus mass immunization by vaccination is the top priority. With knowledge of MERS-SARS (Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome) in hand, researchers are rushing to vaccine development against SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) with newer technological platforms. However, the challenge lies in proving safety, quality and efficacy of vaccine with its resilience to manufacture it in large scales within stipulated time frame. The time consuming nature of classical phased clinical trials are substituted by human volunteer challenge with vaccination of humans engaging undertrial vaccine. This review discusses about various technology platforms being used and tried, their types and challenges in development of vaccine for SARS-CoV-2. Briefly, Indian perspective is also discussed in the race of vaccine development.
A paixão do poema em Herberto Helder
Authors: Carvalho João Pedro
Published: August 2021

Este ensaio analisa o amor na poesia de Herberto Helder, e a sua conceção erótica de poema: transpondo a noção de penetração e fusão para uma teoria de escrita e de leitura. O poema amoroso define-se como reconstrução violenta da amada, como criação da musa que inspira a escrita, num ciclo onanístico. Este afastamento do Outro é a impossibilidade da leitura, e a incessante incitação ao leitor, que nunca conseguirá ler totalmente o poema, e assim o pode continuar a reler, continuando a ser dominado por este instante total de escrita/leitura.
A REPLY TO RONALD DWORKIN’S CRITIQUE OF MORAL SKEPTICISM
Authors: Tormin Mateus Matos
Published: August 2021

This paper focuses on “indeterminacy”, “objectivity” and “truth” in the work of Ronald Dworkin. The text is divided into four parts: first, I will expose the general structure of Dworkin’s conception of objectivity in the moral domain (Section 1). Next, I will present the main critiques Dworkin addresses to two of his most important philosophical enemies, namely the “external skeptic” (Section 2.1) and the “internal skeptic” (Section 2.2). I then intend to address Dworkin’s critiques by presenting counterarguments in defense of moral skepticism (Section 3). In order to clarify the debate and its points, I try to illustrate the arguments with examples whenever possible. In the concluding Section (4), I recapitulate the main points of the text.
JUSTIFICANDO A DESOBEDIÊNCIA CIVIL EM UMA ABORDAGEM POSITIVISTA
Authors: Nascimento Matheus Colares do
Published: August 2021

O objetivo desse trabalho é demostrar como a desobediência civil pode ser tratada no âmbito de uma filosofia do direito de orientação positivista como uma forma de dissenso válida. A princípio, haveria dois obstáculos para isso: o fato de que (1) tal perspectiva seria insensível a acomodar apelos a causas sociais no sistema jurídico e, por isso, (2) a desobediência civil só poderia ser nela compreendida como oferecendo o risco de uma patologia jurídica. Pretendemos mostrar que esses dois pontos são equivocados a partir de conceitos mobilizados por H. L. Hart. Com eles, argumentaremos que as reivindicações feitas através da desobediência civil, na verdade, pressupõem a existência de um sistema jurídico. Por esse motivo, ela não pode apresentar o risco acima.
THE LIBERALISM OF DIVERSITY: A DEFENSE AND SOME CLARIFICATIONS
Authors: Melidoro Domenico
Published: August 2021

Like any book, and regardless of the degree to which it achieves its goals, Dealing with Diversity has inaccuracies and argumentative weaknesses. The careful comments received from Asha Bhandary, Stephen Macedo, and João Cardoso Rosas highlight them lucidly. In what follows, I aim to address some of the points they raise as fairly as I can and, where it is possible, to defend the work I did in my book. At the same time, the reply to such keen remarks gives me the opportunity to clarify some parts that might seem opaque. Before proceeding to consider in some detail the criticisms received, I think it is appropriate to set forth very briefly the purposes of the book.