bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prognostic Value of the Systemic Immune-Inflammation Index (SII) and Red Cell Distribution Width (RDW) in Patients with Cervical Cancer Treated Using Radiotherapy
Authors: Staniewska Emilia , Grudzien Karolina , Stankiewicz Magdalena , Raczek-Zwierzycka Katarzyna , Rembak-Szynkiewicz Justyna , Nowicka Zuzanna , Tarnawski Rafal , Miszczyk Marcin
Published: April 2024

Introduction: There is growing interest in the prognostic value of routinely performed pre-treatment blood test indices, such as the RDW or SII, with the latter combining the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). These indices were shown to be prognostic for survival in some malignancies. The purpose of this study was to evaluate the association between pre-treatment RDW and SII, and OS in patients treated with radiotherapy for primary localised cervical cancer. Material and Methods: This retrospective analysis included patients treated with definitive CRT between 2011 and 2017 for histopathologically confirmed FIGO 2018 stage IB2-IVA cervical cancer. Statistical analysis was performed using the Kaplan–Meier method, two-sided log-rank tests, and Cox proportional hazards models, with the AIC serving as a prediction error estimator. Results: The study group included 249 patients with a median age of 57.2 years and a median follow-up of 75.8 months. The majority were diagnosed with squamous cell carcinoma (237; 95.2%) and had FIGO stage III (211; 84.7%). Approximately half of the patients (116; 46.4%) had regional lymph node metastases. Patients with a low RDW (≤13.4%) and low SII (≤986.01) had a significantly longer OS (p = 0.001 and p = 0.002). The RDW remained as an independent prognostic factor in the multivariable model (high vs. low; HR = 2.04; 95% CI: 1.32–3.16; p = 0.001). Including RDW in the model decreased the Akaike Information Criterion from 1028.25 to 1018.15. Conclusions: The RDW is a cheap and widely available index that is simultaneously an independent prognostic factor for survival and could be used to improve pre-treatment prognosis assessments in patients with cervical cancer undergoing CRT. Available data encourage assessing the RDW as a prognostic factor in prospective trials to aid the identification of candidates for treatment escalation.
Lower Limb Lymphedema Awareness among Gynecological Cancer Patients: An International Survey Supported by the European Network of Gynecological Cancer Advocacy Groups (ENGAGe) Group
Authors: Haidopoulos Dimitrios , Pergialiotis Vasilios , Papageorgiou Maria , Halaska Michael J. , Maxova Katerina , Ulrich Elena , Zapardiel Ignacio , Rodolakis Alexandros , Gultekin Murat , Fotopoulou Christina
Published: April 2024

Introduction: Patient awareness of postoperative lymphedema in the field of gynecologic oncology has been poorly documented in the international literature. We wished to capture and document the awareness among gynecological cancer survivors about postoperative lymphedema, including aspects such as the adequacy of perioperative counseling, management, and quality of life. Methods: A web-based survey comprising 25 multiple-choice questions was distributed to gynecological cancer advocacy groups within the European Network of Gynecological Cancer Advocacy Groups (ENGAGe) group. The survey was validated in a pilot group of gynecological patients prior to distribution. Results: Overall, 386 women from 20 countries completed the questionnaire. Only half of the patients (n = 211) knew what lymphedema is, whereas 52% of the respondents stated that they were never informed at their pre-operative assessment about the potential risk of developing lymphedema. Fifty-three percent of those women who were informed about the risk and management of lymphedema received information through self-initiative, connecting mainly with patient groups or online. Approximately 84% of patients with lymphedema reported that they informed their doctor about their symptoms. Ninety-four patients (55.3%, which is not 55% of the 386) were treated for lymphedema. Forty-five women out of 136 reported that lymphedema significantly affected their everyday lives. Discussion: We report a large lack of awareness and a significant gap of knowledge about the risks and treatment options related to postoperative lymphedema among gynecological cancer survivors. Institutional practice routines and awareness among professionals need to be urgently recalled and adapted to adequately inform and support gynecological cancer patients.
Comparison of Survival Outcomes between Radical Antegrade Modular Pancreatosplenectomy and Conventional Distal Pancreatosplenectomy for Pancreatic Body and Tail Cancer: Korean Multicenter Propensity Score Match Analysis
Authors: Kwon Jaewoo , Lee Huisong , Kim Hongbeom , Kim Sung Hyun , Yang Jae Do , Lee Woohyung , Lee Jun Suh , Shin Sang Hyun , Kim Hee Joon
Published: April 2024

(1) Background: The aim of this study was to compare the survival benefit of radical antegrade modular pancreatosplenectomy (RAMPS) with conventional distal pancreatosplenectomy (cDPS) in left-sided pancreatic cancer. (2) Methods: A retrospective propensity score matching (PSM) analysis was conducted on 333 patients who underwent RAMPS or cDPS for left-sided pancreatic cancer at four tertiary cancer centers. The study assessed prognostic factors and compared survival and operative outcomes. (3) Results: After PSM, 99 patients were matched in each group. RAMPS resulted in a higher retrieved lymph node count than cDPS (15.0 vs. 10.0, p < 0.001). No significant differences were observed between the two groups in terms of R0 resection rate, blood loss, hospital stay, or morbidity. The 5-year overall survival rate was similar in both groups (cDPS vs. RAMPS, 44.4% vs. 45.2%, p = 0.853), and disease-free survival was also comparable. Multivariate analysis revealed that ASA score, preoperative CA19-9, histologic differentiation, R1 resection, adjuvant treatment, and lymphovascular invasion were significant prognostic factors for overall survival. Preoperative CA19-9, histologic differentiation, T-stage, adjuvant treatment, and lymphovascular invasion were independent significant prognostic factors for disease-free survival. (4) Conclusions: Although RAMPS resulted in a higher retrieved lymph node count, survival outcomes were not different between the two groups. RAMPS was a surgical option to achieve R0 resection rather than a standard procedure.
Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
Authors: Braguês Ricardo , Marvão Maria Francisca , Correia Patrícia , Silva Raquel M.
Published: April 2024

Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this systematic review, after applying inclusion/exclusion criteria. Low-level laser therapy, palifermin, honey, and zinc demonstrated reductions in oral mucositis incidence, duration, severity, and pain reported by the patient. Although there are several therapies in place for the prevention and treatment of oral mucositis in children, evidence of their efficacy is still inconclusive to establish accurate clinical protocols.
Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review
Authors: Ward Grados Daniela F. , Ergun Onuralp , Miller Carly D. , Gaburak Petr , Frimpong Nana A. , Shittu Oluwatobi , Warlick Christopher A.
Published: April 2024

Some researchers have speculated that the prostatic microbiome is involved in the development of prostate cancer (PCa) but there is no consensus on certain microbiota in the prostatic tissue of PCa vs. healthy controls. This systematic review aims to investigate and compare the microbiome of PCa and healthy tissue to determine the microbial association with the pathogenesis of PCa. We searched MEDLINE, Embase, and Scopus databases. Articles were screened by two independent and blinded reviewers. Literature that compared the prostatic tissue microbiome of patients with PCa with benign controls was included. We found that PCa may be associated with increased Propionibacterium acnes, the herpesviridae and papillomaviridae families, and Mycoplasma genitalium, but definitive conclusions cannot be drawn from the existing data. Challenges include the difficulty of obtaining uncontaminated tissue samples and securing tissue from healthy controls. As a result, methods are varied with many studies using cancerous and “healthy” tissue from the same prostate. The organisms chosen for each study were also highly variable, making it difficult to compare studies. These issues have led to lower confidence in our results. Overall, further work is warranted to better understand the implications of the prostatic microbiome in the pathogenesis of PCa.
Time-Varying GPS Displacement Network Modeling by Sequential Monte Carlo
Authors: Piriyasatit Suchanun , Kuruoglu Ercan Engin , Ozeren Mehmet Sinan
Published: April 2024

Geodetic observations through high-rate GPS time-series data allow the precise modeling of slow ground deformation at the millimeter level. However, significant attention has been devoted to utilizing these data for various earth science applications, including to determine crustal velocity fields and to detect significant displacement from earthquakes. The relationships inherent in these GPS displacement observations have not been fully explored. This study employs the sequential Monte Carlo method, specifically particle filtering (PF), to develop a time-varying analysis of the relationships among GPS displacement time-series within a network, with the aim of uncovering network dynamics. Additionally, we introduce a proposed graph representation to enhance the understanding of these relationships. Using the 1-Hz GEONET GNSS network data of the Tohoku-Oki Mw9.0 2011 as a demonstration, the results demonstrate successful parameter tracking that clarifies the observations’ underlying dynamics. These findings have potential applications in detecting anomalous displacements in the future.
The Effect of Deposition Time Optimization on the Photovoltaic Performance of Sb2Se3 Thin-Film Solar Cells
Authors: Zhang Jie , Li Shanze
Published: April 2024

Antimony selenide (Sb2Se3) photovoltaic thin-film materials have been recognized as suitable thin-film photovoltaic candidates for sustainable development due to the low toxicity of their constituent elements and abundant reserves. In this study, we employed the close space sublimation (CSS) method to fabricate solar cells with the FTO/SnO2/Sb2Se3/P3HT/C device architecture. By optimizing the deposition time, we achieved (hk1) orientation-preferred Sb2Se3 films, the optimized device exhibited a peak efficiency of 5.06%. This work investigated the growth mechanism of antimony selenide using a complete characterization technique, while the experimental parameters were simulated and matched using Widget Provided Analysis of Microelectronic and Photonic Structures (wxAMPS) showing excellent potential in the deposition of optoelectronic thin films by close space sublimation.
Supporting Functional Goals in Spinal Muscular Atrophy: A Case Report of The Cognitive Orientation to Daily Occupational Performance (CO-OP) Approach
Authors: Taylor Stephanie , Novak Iona , Jackman Michelle
Published: April 2024

Children with spinal muscular atrophy (SMA) are now living longer as a result of advancements in pharmaceutical and medical interventions. There is a paucity of research regarding therapeutic interventions to support this population to be independent and participate in life activities that are most important to them. The aim of this case report is to explore the use of the Cognitive Orientation to daily Occupational Performance (CO-OP) approach to support a child with SMA type 1 to achieve their functional and participation goals. This is a retrospective case study. A 7-year-old girl with SMA type 1 received ten 1 h sessions of CO-OP, weekly in the home and community settings with a physiotherapist. Clinically meaningful improvements were found in goal performance and satisfaction on the Canadian Occupational Performance Measure (COPM) and Performance Quality Rating Scale (PQRS). Despite the progressive nature of SMA, the CO-OP approach was able to support goal attainment. Given medical advances are leading to a longer life span for children with neuromuscular conditions, further research is needed to investigate the efficacy of functional and participation-based interventions, including impact on quality of life and self-efficacy.
eWOM Information Richness and Online User Review Behavior: Evidence from TripAdvisor
Authors: Liu Xueyu , Lin Jie , Jiang Xiaoyan , Chang Tingzhen , Lin Haowen
Published: April 2024

The growing number of online users commenting on review platforms has fueled the development of electronic word–of–mouth (eWOM). At the same time, merchants have improved their requirements for the length and frequency of online reviews. However, few studies have examined the updating mechanism of online reviews length and frequency from the perspective of businesses. This study explores the relationship between online commenting platform users and eWOM and examines how eWOM information richness affects online user review behavior. We used media richness theory (MRT) to quantify the information richness of eWOM content (linguistic, textual, and photographical) to build an empirical framework. For the research data, we used advanced big data analytics to retrieve and analyze TripAdvisor data on restaurant services in nine major tourist destinations, the United States, Mexico, and mainland Europe (including UK, Spain, Netherlands, etc.), over a long period of time. Based on >10 million eWOM, this study used multiple regression to examine the impact of eWOM information richness on online user review behavior, considering the moderating effect of information ambiguity. Our research results show that content information richness positively affects online user review behavior, increasing their frequency and length. Information ambiguity play a moderating role that strengthens this relationship. This supports our theoretical hypothesis. Finally, for greater applicability and reliability, we conducted a comparative study on the degree of differences in the relationship between eWOM and users based on different cultural backgrounds across countries.
Conversion of Polyethylene to Low-Molecular-Weight Oil Products at Moderate Temperatures Using Nickel/Zeolite Nanocatalysts
Authors: Cho Hyungjin , Jin Ahyeon , Kim Sun Ju , Kwon Youngmin , Lee Eunseo , Shin Jaeman J. , Kim Byung Hyo
Published: April 2024

Polyethylene (PE) is the most widely used plastic, known for its high mechanical strength and affordability, rendering it responsible for ~70% of packaging waste and contributing to microplastic pollution. The cleavage of the carbon chain can induce the conversion of PE wastes into low-molecular-weight hydrocarbons, such as petroleum oils, waxes, and natural gases, but the thermal degradation of PE is challenging and requires high temperatures exceeding 400 °C due to its lack of specific chemical groups. Herein, we prepare metal/zeolite nanocatalysts by incorporating small-sized nickel nanoparticles into zeolite to lower the degradation temperature of PE. With the use of nanocatalysts, the degradation temperature can be lowered to 350 °C under hydrogen conditions, compared to the 400 °C required for non-catalytic pyrolysis. The metal components of the catalysts facilitate hydrogen adsorption, while the zeolite components stabilize the intermediate radicals or carbocations formed during the degradation process. The successful pyrolysis of PE at low temperatures yields valuable low-molecular-weight oil products, offering a promising pathway for the upcycling of PE into higher value-added products.
Considerations on the Failure Mechanisms at Fatigue Loading of 1018 Steel Samples Coated with Wip-C1 by Cold Spray
Authors: Alkisswani Layth , Goanță Viorel , Munteanu Corneliu , Samara Fayez , Cosau Roxana Elena , Istrate Bogdan
Published: April 2024

There are some important advantages presented by metal specimens coated with WIP-C1 (Ni/CrC)-type materials. However, given the coating methods and the stress under dynamic loads, there are issues that need to be taken into account, particularly in terms of the behavior at the interface between the two materials. Using standardized cylindrical 1018 steel specimens uniformly coated with WIP-C1 (Ni/CrC) by cold spraying, this study investigated the fatigue behavior of the specimen as a whole, focusing on the interface areas of the two materials. The fatigue life diagram is given, to a large extent, by the behavior of the base material. As a result, in this work, we have focused not so much on the fatigue behavior of the assembly as on the integrity of the coating material and the defects, failures, etc., that may occur at the interface after a certain number of cycles. The applied load was cyclic fatigue through alternating–symmetric cycles. Scanning optical microscopy was used to observe plastic deformations and crack propagation during the breakage process. It was found that both the base material zone and the cover material zone presented good performance when the maximum stresses were at low values. A fatigue durability curve was also plotted, showing a conventional appearance for a metallic material, slightly influenced by the destruction of the base material interface. At higher maximum stress and, consequently, to large strains, a series of destructions at the interface of the two materials, of different types, were observed and will be highlighted in the paper.
A Review of β-Ga2O3 Power Diodes
Authors: He Yongjie , Zhao Feiyang , Huang Bin , Zhang Tianyi , Zhu Hao
Published: April 2024

As the most stable phase of gallium oxide, β-Ga2O3 can enable high-quality, large-size, low-cost, and controllably doped wafers by the melt method. It also features a bandgap of 4.7–4.9 eV, a critical electric field strength of 8 MV/cm, and a Baliga’s figure of merit (BFOM) of up to 3444, which is 10 and 4 times higher than that of SiC and GaN, respectively, showing great potential for application in power devices. However, the lack of effective p-type Ga2O3 limits the development of bipolar devices. Most research has focused on unipolar devices, with breakthroughs in recent years. This review mainly summarizes the research progress fora different structures of β-Ga2O3 power diodes and gives a brief introduction to their thermal management and circuit applications.
The Effect of Height Error on Performance of Propagation Phase-Based Metalens
Authors: Qiu Yongxue , Deng Liangui , Zhan Yujie , Li Gongfa , Guan Jianguo
Published: April 2024

Metalenses, as a new type of planar optical device with flexible design, play an important role in miniaturized and integrated optical devices. Propagation phase-based metalenses, known for their low loss and extensive design flexibility, are widely utilized in optical imaging and optical communication. However, fabrication errors introduced by thin-film deposition and etching processes inevitably result in variations in the height of the metalens structure, leading to the fabricated devices not performing as expected. Here, we introduce a reflective TiO2 metalens based on the propagation phase. Then, the relationship between the height variation and the performance of the metalens is explored by using the maximum phase error. Our results reveal that the height error of the unit structure affects the phase rather than the amplitude. The focusing efficiency of our metalens exhibits robustness to structural variations, with only a 5% decrease in focusing efficiency when the height varies within ±8% of the range. The contents discussed in this paper provide theoretical guidance for the unit design of the propagation phase-based metalens and the determination of its allowable fabrication error range, which is of great significance for low-cost and high-efficiency manufacturing.
The Association between the Plasma Phospholipid Profile and Insulin Resistance: A Population-Based Cross-Section Study from the China Adult Chronic Disease and Nutrition Surveillance
Authors: Pang Shao-Jie , Liu Ting-Ting , Pan Jian-Cun , Man Qing-Qing , Song Shuang , Zhang Jian
Published: April 2024

The dysfunction of phospholipid metabolism enzymes and the change in membrane phospholipid composition are associated with insulin resistance, indicating that phospholipids play an important role in the regulation of insulin sensitivity. The reflection of phospholipid changes in blood might provide clues for both mechanism understanding and intervention. Using a targeted phospholipidomic approach, 199 phospholipid molecular species were identified and quantified in the plasma of 1053 middle-aged participants from a national investigation. The associations of the phospholipid matrix, clusters, and molecular species with insulin resistance were investigated. A significant association was confirmed between the phospholipid matrix and the homeostatic-model assessment of insulin resistance (HOMA-IR) by a distance-based linear model. Furthermore, three clustered phospholipid modules and 32 phospholipid molecular species were associated with HOMA-IR with the strict control of demographic and lifestyle parameters, family history of diabetes, BMI, WC, and blood lipid parameters. The overall decline in lysophosphatidylcholines (LPCs), the decrease in saturated lysophosphatidylethanolamines (LPEs), the decrease in polyunsaturated/plasmenyl phosphatidylcholines (PCs), and the increase in polyunsaturated phatidylethanolamines (PEs) were the prominent characters of plasma phospholipid perturbation associated with insulin resistance. This suggested that PC- and PE-related metabolic pathways were widely involved in the process of insulin resistance, especially the disorder of LPC acylation to diacyl-PC.
The Intelligibility Benefits of Modern Computer-Synthesized Speech for Normal-Hearing and Hearing-Impaired Listeners in Non-Ideal Listening Conditions
Authors: Ma Yizhen , Tang Yan
Published: April 2024

Speech intelligibility is a concern for public health, especially in non-ideal listening conditions where listeners often listen to the target speech in the presence of background noise. With advances in technology, synthetic speech has been increasingly used in lieu of actual human voices in human–machine interfaces, such as public announcement systems, answering machines, virtual personal assistants, and GPS, to interact with users. However, previous studies showed that speech generated by computer speech synthesizers was often intrinsically less natural and intelligible than natural speech produced by human speakers. In terms of noise, listening to synthetic speech is challenging for listeners with normal hearing (NH), not to mention for hearing-impaired (HI) listeners. Recent developments in speech synthesis have significantly improved the naturalness of synthetic speech. In this study, the intelligibility of speech generated by commercial synthesizers from Google, Amazon, and Microsoft was evaluated by both NH and HI listeners in different noise conditions. Compared to a natural female voice as the baseline, listeners’ listening performance suggested that some of the synthetic speech was significantly more intelligible even at rather adverse listening conditions for the NH cohort. Further acoustical analyses revealed that elongated vowel sounds and reduced spectral tilt were primarily responsible for improved intelligibility for NH, but not for HI due to their impairment at high frequencies and possible cognitive decline associated with aging.
The Epidemiology of Newly Recognized Causes of Drug-Induced Liver Injury: An Update
Authors: Björnsson Einar Stefan
Published: April 2024

The incidence and prevalence of drug-induced liver injury appear to be increasing globally, for example, with the introduction of checkpoint inhibitors. Several reviews have been published in the last decade on the epidemiology of DILI, both among hospitalized patients and in the general population, as well as from retrospective and prospective studies on DILI. Most of these reviews have not focused on newly recognized agents that have recently changed the landscape of DILI. Apart from liver injury associated with antibiotics, oncological agents, particularly checkpoint inhibitors, are increasingly being recognized as causing liver injury. The type of liver injury associated with these agents is not idiosyncratic but rather an indirect type of injury. Furthermore, recently, COVID-19 vaccines and green tea extract have been found to lead to liver injury. Checkpoint inhibitors have revolutionized the treatment of many malignancies, such as malignant melanoma, lung cancer, and renal cancer. Via the activation of T cells, they can increase immune activity against malignant cells, but at the same time, they can decrease immune tolerance and therefore lead to immune-related adverse effects in many organs. The most common adverse effect in clinical practice is liver injury. A recent prospective study demonstrated an 8% frequency of DILI due to the use of checkpoint inhibitors among patients with malignant melanoma and renal cancer. This rate is much higher than observed with drugs, leading to idiosyncratic liver injury. Shortly after the implementation of the worldwide vaccination program against COVID-19, several case reports were published on suspected vaccination-induced autoimmune-like hepatitis occurring shortly after the vaccination. At first, these reports were met with skepticism, but currently, around 100 reports have been published, and cases of positive recurrence have been reported. The clinical, biochemical, immunological, and histological features are indistinguishable from classic autoimmune hepatitis (AIH). These reactions are very similar to drug-induced autoimmune-like hepatitis (DI-ALH) due to drugs such as nitrofurantoin, minocycline, and infliximab, which do not relapse after a short course of corticosteroids, which is the general rule in classic autoimmune hepatitis (AIH). Green tea extract has been found to be a well-documented cause of acute hepatocellular liver injury with jaundice. A strong HLA association has been reported, showing a high prevalence of HLA-B*35:01 among patients suffering from green tea-induced liver injury. Overall, 3% of patients recruited in the DILIN study were supplemented with green tea extract as one of the ingredients. In a prospective population-based study from Iceland, green tea was implicated in approximately 8% of patients with DILI.
Melanin Biopolymers in Pharmacology and Medicine—Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy
Authors: Karkoszka Marta , Rok Jakub , Wrześniok Dorota
Published: April 2024

Melanins are biopolymeric pigments formed by a multi-step oxidation process of tyrosine in highly specialized cells called melanocytes. Melanin pigments are mainly found in the skin, iris, hair follicles, and inner ear. The photoprotective properties of melanin biopolymers have been linked to their perinuclear localization to protect DNA, but their ability to scavenge metal ions and antioxidant properties has also been noted. Interactions between drugs and melanins are of clinical relevance. The formation of drug–melanin complexes can affect both the efficacy of pharmacotherapy and the occurrence of adverse effects such as phototoxic reactions and discoloration. Because the amount and type of melanin synthesized in the body is subject to multifactorial regulation—determined by both internal factors such as genetic predisposition, inflammation, and hormonal balance and external factors such as contact with allergens or exposure to UV radiation—different effects on the melanogenesis process can be observed. These factors can directly influence skin pigmentation disorders, resulting in hypopigmentation or hyperpigmentation of a genetic or acquired nature. In this review, we will present information on melanocyte biology, melanogenesis, and the multifactorial influence of melanin on pharmacological parameters during pharmacotherapy. In addition, the types of skin color disorders, with special emphasis on the process of their development, symptoms, and methods of treatment, are presented in this article.
Polymeric Amorphous Solid Dispersions of Dasatinib: Formulation and Ecotoxicological Assessment
Authors: Sokač Katarina , Miloloža Martina , Kučić Grgić Dajana , Žižek Krunoslav
Published: April 2024

Dasatinib (DAS), a potent anticancer drug, has been subjected to formulation enhancements due to challenges such as significant first-pass metabolism, poor absorption, and limited oral bioavailability. To improve its release profile, DAS was embedded in a matrix of the hydrophilic polymer polyvinylpyrrolidone (PVP). Drug amorphization was induced in a planetary ball mill by solvent-free co-grinding, facilitating mechanochemical activation. This process resulted in the formation of amorphous solid dispersions (ASDs). The ASD capsules exhibited a notable enhancement in the release rate of DAS compared to capsules containing the initial drug. Given that anticancer drugs often undergo limited metabolism in the body with unchanged excretion, the ecotoxicological effect of the native form of DAS was investigated as well, considering its potential accumulation in the environment. The highest ecotoxicological effect was observed on the bacteria Vibrio fischeri, while other test organisms (bacteria Pseudomonas putida, microalgae Chlorella sp., and duckweed Lemna minor) exhibited negligible effects. The enhanced drug release not only contributes to improved oral absorption but also has the potential to reduce the proportion of DAS that enters the environment through human excretion. This comprehensive approach highlights the significance of integrating advances in drug development while considering its environmental implications.
Detecting Moving Wildlife Using the Time Difference between Two Thermal Airborne Images
Authors: Oishi Yu , Yoshida Natsuki , Oguma Hiroyuki
Published: April 2024

Wildlife damage to agriculture is serious in Japan; therefore, it is important to understand changes in wildlife population sizes. Although several studies have been conducted to detect wildlife from drone images, behavioral changes (such as wildlife escaping when a drone approaches) have been confirmed. To date, the use of visible and near-infrared images has been limited to the daytime because many large mammals, such as sika deer (Cervus nippon), are crepuscular. However, it is difficult to detect wildlife in the thermal images of urban areas that are not open and contain various heat spots. To address this issue, a method was developed in a previous study to detect moving wildlife using pairs of time-difference thermal images. However, the user’s accuracy was low. In the current study, two methods are proposed for extracting moving wildlife using pairs of airborne thermal images and deep learning models. The first method was to judge grid areas with wildlife using a deep learning classification model. The second method detected each wildlife species using a deep learning object detection model. The proposed methods were then applied to pairs of airborne thermal images. The classification test accuracies of “with deer” and “without deer” were >85% and >95%, respectively. The average precision of detection, precision, and recall were >85%. This indicates that the proposed methods are practically accurate for monitoring changes in wildlife populations and can reduce the person-hours required to monitor a large number of thermal remote-sensing images. Therefore, efforts should be made to put these materials to practical use.
Assessing Greenhouse Gas Monitoring Capabilities Using SolAtmos End-to-End Simulator: Application to the Uvsq-Sat NG Mission
Authors: Clavier Cannelle , Meftah Mustapha , Sarkissian Alain , Romand Frédéric , Hembise Fanton d’Andon Odile , Mangin Antoine , Bekki Slimane , Dahoo Pierre-Richard , Galopeau Patrick , Lefèvre Franck , Hauchecorne Alain , Keckhut Philippe
Published: April 2024

Monitoring atmospheric concentrations of greenhouse gases (GHGs) like carbon dioxide and methane in near real time and with good spatial resolution is crucial for enhancing our understanding of the sources and sinks of these gases. A novel approach can be proposed using a constellation of small satellites equipped with miniaturized spectrometers having a spectral resolution of a few nanometers. The objective of this study is to describe expected results that can be obtained with a single satellite named Uvsq-Sat NG. The SolAtmos end-to-end simulator and its three tools (IRIS, OptiSpectra, and GHGRetrieval) were developed to evaluate the performance of the spectrometer of the Uvsq-Sat NG mission, which focuses on measuring the main GHGs. The IRIS tool was implemented to provide Top-Of-Atmosphere (TOA) spectral radiances. Four scenes were analyzed (pine forest, deciduous forest, ocean, snow) combined with different aerosol types (continental, desert, maritime, urban). Simulated radiance spectra were calculated based on the wavelength ranges of the Uvsq-Sat NG, which spans from 1200 to 2000 nm. The OptiSpectra tool was used to determine optimal observational settings for the spectrometer, including Signal-to-Noise Ratio (SNR) and integration time. Data derived from IRIS and OptiSpectra served as input for our GHGRetrieval simulation tool, developed to provide greenhouse gas concentrations. The Levenberg–Marquardt algorithm was applied iteratively to fine-tune gas concentrations and model inputs, aligning observed transmittance functions with simulated ones under given environmental conditions. To estimate gas concentrations (CO2, CH4, O2, H2O) and their uncertainties, the Monte Carlo method was used. Based on this analysis, this study demonstrates that a miniaturized spectrometer onboard Uvsq-Sat NG is capable of observing different scenes by adjusting its integration time according to the wavelength. The expected precision for each measurement is of the order of a few ppm for carbon dioxide and less than 25 ppb for methane.
A Multiscale Filtering Method for Airborne LiDAR Data Using Modified 3D Alpha Shape
Authors: Cao Di , Wang Cheng , Du Meng , Xi Xiaohuan
Published: April 2024

The complexity of terrain features poses a substantial challenge in the effective processing and application of airborne LiDAR data, particularly in regions characterized by steep slopes and diverse objects. In this paper, we propose a novel multiscale filtering method utilizing a modified 3D alpha shape algorithm to increase the ground point extraction accuracy in complex terrain. Our methodology comprises three pivotal stages: preprocessing for outlier removal and potential ground point extraction; the deployment of a modified 3D alpha shape to construct multiscale point cloud layers; and the use of a multiscale triangulated irregular network (TIN) densification process for precise ground point extraction. In each layer, the threshold is adaptively determined based on the corresponding α. Points closer to the TIN surface than the threshold are identified as ground points. The performance of the proposed method was validated using a classical benchmark dataset provided by the ISPRS and an ultra-large-scale ground filtering dataset called OpenGF. The experimental results demonstrate that this method is effective, with an average total error and a kappa coefficient on the ISPRS dataset of 3.27% and 88.97%, respectively. When tested in the large scenarios of the OpenGF dataset, the proposed method outperformed four classical filtering methods and achieved accuracy comparable to that of the best of learning-based methods.
What Are Investors Most Interested in about Sustainability? An Approach from the Scientific Literature
Authors: Oliveros Fontaine Juan , del Campo Cristina , Urquía-Grande Elena
Published: April 2024

In the midst of the development of international frameworks for the dissemination of information on sustainability, the European Union published the Corporate Sustainability Reporting Directive (CSRD) in order to meet user requirements on sustainability. To achieve its objectives, the Directive assigns large companies and investors a key role in the transmission of sustainability-related information, leveraging their capacity to influence. An increased separate use of the term “investor” has been noted in the sustainability-related literature regarding the overall “stakeholder” that contains it. Our research applies a methodology based on analysis of the content of the abstracts from 260 articles published prior to the approval of the CSRD, with the aim of identifying whether that separate use implied that investors’ interests are concentrated on sustainability-related aspects. The results of the research concluded that there is no statistical significance between the separate, growing use of the term “investor” and a generalised use in the lexical field related to sustainability that might characterise the influence of investors. This work encourages future research directions to examine how the enactment of the CSRD may affect the trend in investor influence on the dissemination of sustainability-related information.
Analysis of the Factors Influencing the Spatial Distribution of PM2.5 Concentrations (SDG 11.6.2) at the Provincial Scale in China
Authors: Li Jun , Chen Yu , Chen Fang
Published: April 2024

This study investigated the spatiotemporal characteristics and influencing factors of PM2.5 concentrations at the provincial scale in China. The findings indicate significant spatial autocorrelation, with notable high–high agglomerations in East and North China and mixed patterns in the northwest. The spatial Durbin model (SDM) with fixed effects, validated through comprehensive tests, was utilized to analyze data on 31 provincial scale regions from 2000 to 2020, addressing spatial autocorrelation and ensuring model reliability. The research delved into the effects of 21 variables on PM2.5 concentrations, identifying synergistic and trade-off effects among environmental and socioeconomic indicators. Environmental measures like vegetation protection and sulfur dioxide emission reduction correlate with lower PM2.5 levels, whereas economic growth and transport volume often align with increased pollution. The analysis reveals regional variances in these effects, suggesting the need for region-specific policies. The study underscores the intricate relationship between environmental policies, economic development, and air quality, advocating for an integrated approach to air quality improvement. It highlights the necessity of balancing industrial growth with environmental sustainability and suggests targeted, region-specific strategies to combat PM2.5 pollution effectively. This study offers crucial insights for policymakers, emphasizing that enhancing air quality requires comprehensive strategies that encompass environmental, economic, and technological dimensions to foster sustainable development.
Vulnerability Assessment of a Highly Populated Megacity to Ambient Thermal Stress
Authors: Gupta Aman , De Bhaskar , Shukla Anoop Kumar , Pignatta Gloria
Published: April 2024

The urban ambient environment is directly responsible for the health conditions of millions of people. Comfortable living space is a significant aspect that urban policymakers need to address for sustainable planning. There is still a notable lack of studies that link the spatial profile of urban climate with city-specific built-up settings while assessing the vulnerability of the city population. Geospatial approaches can be beneficial in evaluating patterns of thermal discomfort and strategizing its mitigation. This study attempts to provide a thorough remote sensing framework to analyze the summer magnitude of thermal discomfort for a city in a tropical hot and humid climate. Spatial profiles of dry bulb temperature, wet bulb temperature and relative humidity were prepared for this purpose. A simultaneous assessment of various discomfort indices indicated the presence of moderate to strong heat stress to a vast extent within the study area. The central business district (CBD) of the city indicated a ‘danger’ level of heat disorder for outdoor exposure cases. Nearly 0.69 million people were vulnerable to a moderate threat from humid heat stress, and around 0.21 million citizens faced strong heat stress. Combing city morphology in the study showed that mid-rise buildings had the maximum contribution in terms of thermal discomfort. City areas with built-up cover of more than 68%, along with building height between 5.8 m and 9.3 m, created the worst outdoor discomfort situations. Better land management prospects were also investigated through a multicriteria approach using morphological settlement zones, wind direction, pavement watering, building regulations and future landscaping plans. East–west-aligned road segments of a total 38.44 km length were delineated for water spray cooling and greener pavements. This study is likely to provide solutions for enhancing ambient urban health.
A Study of the Spatial–Temporal Development Patterns and Influencing Factors of China’s National Archaeological Site Parks
Authors: Xi Yueting , Liu Taili , Chen Siliang , Zhang Xinru , Qu Suyi , Dong Yue
Published: April 2024

National Archaeological Site Parks are strategic projects in China for innovatively exploring the scientific protection and rational utilization of large heritage sites for the purpose of balancing urban development and protecting cultural heritage. Therefore, research on the spatial–temporal evolution and influencing factors of National Archaeological Site Parks can improve and optimize their management and pattern systems and is therefore of great significance for the sustainable development of large sites and their surrounding areas. Targeting the 135 National Archaeological Site Parks of China, this paper adopts the nearest-neighbor index analytical method, the kernel density estimation method, the standard deviation ellipse method, the method of constructing an indicator system, and an SPSS factor analysis method to analyze the spatial–temporal evolution and influencing factors of these parks. The findings are as follows: (1) In terms of the temporal evolution, the number of National Archaeological Site Parks increased from 2010 to 2022, and the ages and types of the large heritage sites they are built upon gradually became more balanced and diverse. (2) In terms of the spatial evolution, National Archaeological Site Parks form two high-density areas in Central China and East China. Their overall distribution is consistent with China’s “Hu Line”. (3) In terms of spatial–temporal evolution, the center of gravity of National Archaeological Site Parks’ distribution is advancing toward Southwest China, and the trend of a more balanced distribution is rising. (4) Finally, regional development, heritage tourism, historical resources, and government support were observed to be factors that affect the spatial–temporal patterns of the National Archaeological Site Parks. Based on these findings, we propose specific strategies for coordinating and linking the above four major influencing factors to promote the rational utilization of large heritage sites and the sustainable development of National Archaeological Site Parks. We aim to improve and optimize the management and pattern systems of National Archaeological Site Parks, to promote urban renewal based on large heritage sites, and to provide valuable insights for policy makers and heritage practitioners in other countries with historical resources around the world.
Assessing the Impact of Lignite-Based Rekulter Fertilizer on Soil Sustainability: A Comprehensive Field Study
Authors: Maciejewska Alina , Sobieraj Janusz , Metelski Dominik
Published: April 2024

This study aimed to investigate the impact of Rekulter, a lignite-based fertilizer, on various soil parameters, with a focus on promoting sustainable agricultural practices. A multi-year field trial was conducted in Klon, Poland, employing potentiometric techniques, spectrophotometry, and gas chromatography-mass spectrometry to analyze soil samples. Established laboratory procedures were used to assess pH value, sorption properties, granulometric composition, organic carbon content (OC), total nitrogen (TN), polycyclic aromatic hydrocarbons (PAHs), phenolic compounds (PCs), and the fractional composition of organic matter. Hypothesis-driven experiments, including Analysis of Variance (ANOVA) and Tukey’s HSD post hoc tests, were utilized to examine the effects of Rekulter application on soil characteristics. Significant differences were found in organic carbon (OC), total nitrogen (TN), polycyclic aromatic hydrocarbons (PAHs), phenolic compounds (PCs), and fractional organic matter composition among the Rekulter variants. This study underscores the dose-dependent effects of Rekulter on soil properties and provides insights into optimizing application rates for sustainable soil management. Recommendations include tailoring agricultural interventions based on soil characteristics and environmental considerations, integrating organic amendments with mineral fertilizers, and promoting balanced approaches to reclamation. This research contributes to ongoing efforts to improve agricultural sustainability and mitigate environmental impacts, guiding practices that balance productivity with environmental stewardship.
Nonlinear Impact of Corporate Financialization on Sustainable Development Ability: Evidence from Listed Companies in China
Authors: Chen Shuanglian , Nie Benhuan , Huang Xiaohua
Published: April 2024

This paper takes 1179 non-financial listed companies in China from 2010 to 2021 as samples and constructs a panel fixed-effect model to examine the effect of corporate financialization on sustainable development ability. Also, we further use the moderating effect model and the mediating effect model to explore the moderating roles played by financing constraints and environmental uncertainty, as well as the influencing mechanisms transmitted by financialization motives. The results are as follows: (1) There is a significant and robust inverted U-shaped relationship between corporate financialization and sustainable development ability, which indicates the existence of a moderate range of corporate financialization in regard to the sustainable development ability of companies. (2) Financing constraints and environmental uncertainty have moderating effects on the inverted U-shaped relationship between corporate financialization and sustainable development ability. With high financing constraints (environmental uncertainty), the sustainable development ability of companies reacts more sensitively to thep change in corporate financialization level. (3) Companies hold financial assets with precautionary saving motive in the low financialization level, and the reservoir effect plays a dominant role. The sustainable development ability of companies is enhanced. However, companies increase their holdings of financial assets for speculative arbitrage motive in the high financialization level, where the short-term wealth effect becomes dominant. The results of this paper are helpful for companies’ decision-making in sustainable development and for government policy formulation in economic development.