bluuebunny/crossref_metadata_2025 huggingface dataset:
Association between Mid-Term Functionality and Clinical Severity in Patients Hospitalized for Pulmonary Embolism
Authors: Gámiz-Molina Ana Belén , Valenza-Peña Geraldine , Raya-Benítez Julia , Heredia-Ciuró Alejandro , Granados-Santiago María , López-López Laura , Valenza Marie Carmen
Published: July 2024

The aim of this study is to evaluate the relationship between clinical severity and functionality, occupational performance, and health-related quality of life in patients hospitalized with pulmonary embolism. Pulmonary embolism patients were grouped by clinical severity using the Pulmonary Embolism Severity Index. Those scoring ≥160 were in the high-severity group (HSG); those scoring < 160 in the low–moderate group (LMSG). The main variables were functionality assessed by the World Health Organization Disability Assessment Schedule (WHODAS), self-perception of occupational performance assessed by the Canadian Occupational Performance Measure (COPM), pain and fatigue assessed by a Visual Analogue Scale (VAS), and health-related quality of life assessed by the EuroQol-5Dimensions (EQ-5D). Patients were evaluated at hospital admission and at 1-month and 3-month follow-up. At admission, there were significant differences between groups in the WHODAS and health-related quality of life in favor of the LMSG. At 1-month and at 3-month follow-up, there were significant differences between the LMSG and HSG in WHODAS, COMP, NRS pain, fatigue and EQ-5D scores in favor of the LMSG. An association exists between clinical severity and mid-term functionality, self-perception of occupational performance, pain, fatigue, and health-related quality of life in PE patients.
Occupational Physical Activity and Fitness in Predicting Cardiovascular Mortality among European Cohorts of Middle-Aged Men: A 60-Year Follow-Up in the Seven Countries Study
Authors: Puddu Paolo Emilio , Kafatos Anthony , Tolonen Hanna , Geleijnse Johanna M. , Menotti Alessandro
Published: July 2024

Aim and Background: To determine whether occupational physical activity (OPA) and physical fitness (Fitscore) predict cardiovascular disease (CVD) mortality and its components. Methods: Among middle-aged men (N = 5482) of seven cohorts of the Seven Countries Study (SCS), several baseline risk factors were measured, and there was a follow-up for 60 years until virtual extinction. OPA was estimated from the type of work while Fitscore was derived from linear combinations of levels of arm circumference, heart rate and vital capacity computed as a factor score by principal component analysis. The predictive adjusted power of these characteristics was obtained by Cox models for coronary heart disease (CHD), heart diseases of uncertain etiology (HDUE), stroke and CVD outcomes. Results: Single levels of the three indicators of fitness were highly related to the three levels of OPA and Fitscore. High levels of both OPA and Fitscore forced into the same models were associated with lower CVD, CHD, HDUE and stroke mortality. When assessed concomitantly in the same models, hazard ratios (high versus low) for 60-year CVD mortality were 0.88 (OPA: 95% CI: 0.78–0.99) and 0.68 (Fitscore 95% CI: 0.61–0.75), and the predictive power of Fitscore outperformed that of OPA for CHD, HDUE and stroke outcomes. Similar results were obtained in individual outcome models in the presence of risk factors. Segregating the first 30 from the second 30 years of follow-up indicated that people dying earlier had lower arm circumference and vital capacity, whereas heart rate was higher for CVD and most of its major components (all p < 0.0001). Conclusions: OPA was well related to the indicators of fitness involving muscular mass, cardio-circulatory and respiratory functions, thus adding predictive power for CVD events. The Fitscore derived from the above indicators represents another powerful long-term predictor of CHD, HDUE and stroke mortality.
Methodological Proposal to Resolve the Dichotomy between Improving Energy Efficiency and Preserving Heritage—Case Study: Brutalist Built Heritage
Authors: Uranga Eneko J. , Lizundia Iñigo , Azcona Leire
Published: July 2024

The debate about how to conduct energy interventions in built heritage remains open. At present, the various European and national regulations allow the absence of energy intervention in cases where the character of a building with recognized heritage value would be jeopardized. This situation means that heritage preservation and energy improvement are divided into two airtight and unconnected blocs. It is possible and necessary to break that dichotomy by taking steps that enable both blocs to interrelate. Based on a methodology previously proposed by the authors to regulate changes in the urban landscape due to the rehabilitation of residential building façades, as a novel aspect, this article proposes taking a further step in the methodological process. Several criteria to balance the level of energy intervention for all buildings are thus introduced, according to the urban and architectural characteristics of each building, irrespective of their use and degree of protection. It is concluded that such a balance is possible when certain indicators are used and when determined action criteria are applied. However, one of the architectural characteristics more susceptible to being affected when undertaking an energy intervention on a building’s thermal enclosure is the materiality, which becomes especially important in the case of brutalist architecture with reinforced concrete, one of its most identifying features, giving it a specific personality. That architectural movement was therefore chosen for a case study, applying the proposed methodology to three brutalist buildings in the area of San Sebastián, Spain.
Comparison of the Proteome of Staphylococcus aureus Planktonic Culture and 3-Day Biofilm Reveals Potential Role of Key Proteins in Biofilm
Authors: Rahman Md. Arifur , Amirkhani Ardeshir , Chowdhury Durdana , Vickery Karen , Hu Honghua
Published: July 2024

Staphylococcus aureus and coagulase-negative staphylococci account for about 80% of infections associated with medical devices and are associated with increased virulence due to their ability to form biofilm. In this study, we aimed to construct a comprehensive reference map followed by significant pathway analysis in the proteome of S. aureus biofilm grown for 3 days compared with 24 h of planktonic culture using a high-resolution Tandem Mass Tag (TMT)-based MS. We identified proteins associated with secondary metabolites, ABC transporters, biosynthesis of amino acids, and response to stress, and amino sugar and nucleotide sugar metabolism were significantly upregulated in 3-day biofilm. In contrast, proteins associated with virulence factors, microbial metabolism in diverse environments, secondary metabolites, translation, and energy metabolism were significantly downregulated. GO functional annotation indicated that more proteins are involved in metabolic processes, catalytic activity, and binding in biofilm, respectively. Among the significantly dysregulated proteins, hyaluronidase (hysA) in conjunction with chitinase may play a significant role in the elimination and/or prevention of biofilm development. This study advances the understanding of the S. aureus subproteome, identifying potential pathways significant to biofilm biology. The insights gained may aid in developing new therapeutic strategies, including antibiofilm agents, for treating biofilm-related infections associated with implantable medical devices.
International Journal of Topology
Authors: Planat Michel
Published: July 2024

Welcome to the new open access journal: the International Journal of Topology (IJT), published by MDPI [...]
Understanding Travel Behaviors and Mobility Challenges Faced by Older Adults during the COVID-19 Pandemic
Authors: Saha Troyee , Lee Kathy , Hyun Kate Kyung , Cassidy Jessica , Jang Soeun
Published: July 2024

Background: During the COVID-19 pandemic, older adults were considered one of the most vulnerable groups as they faced obstacles when traveling for daily activities. This study examined the impact of the pandemic on travel behaviors among older adults, aiming to shed light on the challenges they faced and potential strategies for support. Methods: We conducted semi-structured, individual interviews with older adults. The data were analyzed using thematic analysis. In addition, their trip frequencies and usage of different transportation modes were descriptively analyzed. Results: While the participants reduced overall trip frequency during the pandemic, they were more observant when discussing essential needs. Study participants emphasized their reliance on family members for rides to essential destinations. Non-drivers faced added stressors and fears, particularly regarding safety measures and hygiene protocols on public transportation. Several individuals embraced ride-hailing services as a viable transportation solution, indicating benefits such as reduced exposure to crowded public transit and increased convenience. Conclusions: Macro-level efforts should include supplementary technological and transportation assistance services, along with increased awareness of safety protocols within public transit. These initiatives are expected to enhance the accessibility of existing mobility systems for older adults.
Asymptomatic Chronic Large Pericardial Effusions: To Drain or to Observe?
Authors: Lazarou Emilia , Vlachopoulos Charalambos , Antonopoulos Alexios , Imazio Massimo , Brucato Antonio , Tsioufis Costas , Lazaros George
Published: July 2024

Pericardial effusions, especially large ones, have traditionally been regarded with concern by clinicians due to the sometimes unpredictable development of life-threatening cardiac tamponade. In the European Society of Cardiology Guidelines on pericardial diseases, the simplified algorithm for pericardial effusion triage and management recommends pericardial drainage in cases of cardiac tamponade and/or suspicion of bacterial or neoplastic etiology. In the presence of acute pericarditis, empiric anti-inflammatory treatment should be given, while when a specific indication known to be associated with pericardial effusion is found, then treatment of the underlying cause is indicated. Notably, the most challenging subgroup of patients includes those with large, asymptomatic, C-reactive-protein-negative, idiopathic effusions. In the latter subjects, pericardial drainage is proposed in cases of chronic effusions (lasting more than three months). However, this recommendation is based on scant data stemming from small-sized non-randomized studies. Nevertheless, recent evidence in a larger cohort of patients pointed out that a watchful waiting strategy is a safe option in terms of complication-free survival. This review summarizes the contemporary evidence on this challenging topic and provides recommendations for tailoring individual patient treatments.
Bone: A Neglected Endocrine Organ?
Authors: Szeliga Anna , Grymowicz Monika , Kostrzak Anna , Smolarczyk Roman , Bala Gregory , Smolarczyk Katarzyna , Meczekalski Blazej , Suchta Katarzyna
Published: July 2024

Bone has traditionally been viewed in the context of its structural contribution to the human body. Foremost providing necessary support for mobility, its roles in supporting calcium homeostasis and blood cell production are often afterthoughts. Recent research has further shed light on the ever-multifaceted role of bone and its importance not only for structure, but also as a complex endocrine organ producing hormones responsible for the autoregulation of bone metabolism. Osteocalcin is one of the most important substances produced in bone tissue. Osteocalcin in circulation increases insulin secretion and sensitivity, lowers blood glucose, and decreases visceral adipose tissue. In males, it has also been shown to enhance testosterone production by the testes. Neuropeptide Y is produced by various cell types including osteocytes and osteoblasts, and there is evidence suggesting that peripheral NPY is important for regulation of bone formation. Hormonal disorders are often associated with abnormal levels of bone turnover markers. These include commonly used bone formation markers (bone alkaline phosphatase, osteocalcin, and procollagen I N-propeptide) and commonly used resorption markers (serum C-telopeptides of type I collagen, urinary N-telopeptides of type I collagen, and tartrate-resistant acid phosphatase type 5b). Bone, however, is not exclusively comprised of osseous tissue. Bone marrow adipose tissue, an endocrine organ often compared to visceral adipose tissue, is found between trabecula in the bone cortex. It secretes a diverse range of hormones, lipid species, cytokines, and other factors to exert diverse local and systemic effects.
Association between Pericarotid Fat Density and Positive Remodeling in Patients with Carotid Artery Stenosis
Authors: Kashiwazaki Daina , Yamamoto Shusuke , Akioka Naoki , Hori Emiko , Noguchi Kyo , Kuroda Satoshi
Published: July 2024

Background/Objectives: The underlying mechanism of the potential involvement of inflammatory crosstalk between pericarotid fat and vascular layers in atherosclerosis pathogenesis is unclear. We investigated the association between pericarotid fat density and positive remodeling and inflammatory markers in carotid stenosis. We hypothesized that pericarotid fat density might serve as a marker of plaque inflammation in a clinical setting. Methods: We evaluated the stenosis degree and pericarotid fat density in 258 patients with carotid plaques. Plaque composition was examined, and the correlation between pericarotid fat density and expansive remodeling was investigated. Pearson’s product–moment correlation coefficient was used to examine the relationship between pericarotid fat density and the expansive remodeling ratio. We also evaluated the relationship of pericarotid fat density with plaque composition, degree of stenosis, and macrophage and microvessel counts by. The subgroup analysis compared these factors between symptomatic mild carotid stenosis. Results: The pericarotid fat density was −63.0 ± 11.1 HU. The carotid fat densities were −56.8 ± 10.4 HU in symptomatic and −69.2 ± 11.4 HU in asymptomatic lesions. The pericarotid fat density values in intraplaque hemorrhage, lipid-rich necrotic core, and fibrous plaque were −51.6 ± 10.4, −59.4 ± 12.8, and −74.2 ± 8.4 HU, respectively. Therefore, the expansive remodeling ratio was 1.64 ± 0.4. Carotid fat density and expansive remodeling ratio were correlated. Immunohistochemistry showed high macrophage and microvessel levels (143.5 ± 61.3/field and 121.2 ± 27.7/field, respectively). In symptomatic mild carotid stenosis, pericarotid fat density was correlated with other inflammatory factors. The pericarotid fat density and expansive remodeling ratio (2.08 ± 0.21) were high in mild stenosis (−50.1 ± 8.4 HU). Conclusions: Pericarotid fat and intraplaque components were well correlated. Carotid fat density may be a marker of plaque inflammation in carotid plaques.
Ramadan Fasting in Individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease, Liver Transplant, and Bariatric Surgery: A Narrative Review
Authors: Ahmed Musaab , Ahmed Mohamed H.
Published: July 2024

Metabolic dysfunction-associated steatotic liver disease is a growing worldwide pandemic. A limited number of studies have investigated the potential effect of Ramadan fasting on metabolic dysfunction-associated steatotic liver disease (MASLD). There is no single medication for the treatment of MASLD. There is a growing interest in dietary intervention as potential treatment for metabolic diseases including MASLD. The aim of this study was to discuss the epidemiology, pathogenesis, and risk factors of MASLD and the potential effects of Ramadan fasting on MASLD, liver transplant, and bariatric surgery. We searched PubMed and SCOPUS databases using different search terms. The literature search was based on research studies published in English from the year 2000 to the 2024. Thirty-two studies were included in this review. Ramadan fasting reduced body weight and improved lipid profile, anthropometric indices, fasting plasma glucose, plasma insulin, and inflammatory cytokines. Ramadan fasting improved risk factors of nonalcoholic fatty liver disease and might improve MASLD through weight reduction. However, further studies are needed to assess the safety and effectiveness of Ramadan fasting in liver transplant recipients and bariatric surgery.
Discussing on the Aortic Coverage in Type B Aortic Dissection Treatment: A Comprehensive Scoping Review
Authors: Bissacco Daniele , de Kort Jasper F. , Ramella Anna , Allievi Sara , Bellotti Paolo , Casana Renato , Domanin Maurizio , Migliavacca Francesco , Trimarchi Santi
Published: July 2024

Objective: The objective of this study is to investigate and address the question surrounding the determination of the optimal endograft length of coverage during TEVAR for type B aortic dissection (TBAD), with a particular emphasis on the distal landing zone (DLZ). Data sources: MEDLINE, Scopus, and Web of Science databases were used. Methods: The PRISMA-ScR statement was followed. Results: Several variables can contribute to the length of coverage during TEVAR in TBAD patient. Baseline patient’s characteristics, TBAD-related features, the type of endoprosthesis, and postoperative graft behaviour may contribute to the choice of coverage. Conclusions: No robust data have been published regarding the optimal length of TEVAR. Therefore, reporting the percentage of covered aorta and improving computational studies should be valorised to improve postoperative outcomes.
Humans and Automation: Augmenting Security Operation Centers
Authors: Tilbury Jack , Flowerday Stephen
Published: July 2024

The continuous integration of automated tools into security operation centers (SOCs) increases the volume of alerts for security analysts. This amplifies the risk of automation bias and complacency to the point that security analysts have reported missing, ignoring, and not acting upon critical alerts. Enhancing the SOC environment has predominantly been researched from a technical standpoint, failing to consider the socio-technical elements adequately. However, our research fills this gap and provides practical insights for optimizing processes in SOCs. The synergy between security analysts and automation can potentially augment threat detection and response capabilities, ensuring a more robust defense if effective human-automation collaboration is established. A scoping review of 599 articles from four databases led to a final selection of 49 articles. Thematic analysis resulted in 609 coding references generated across four main themes: SOC automation challenges, automation application areas, implications on analysts, and human factor sentiment. Our findings emphasize the extent to which automation can be implemented across the incident response lifecycle. The SOC Automation Matrix represents our primary contribution to achieving a mutually beneficial relationship between analyst and machine. This matrix describes the properties of four distinct human-automation combinations. This is of practical value to SOCs striving to optimize their processes, as our matrix mentions socio-technical system characteristics for automated tools.
Insulin-Resistant Male LEW.1WR1 Rats Do Not Develop β-Cell Mass Expansion in Response to a Moderate Sucrose Diet
Authors: Wilkerson-Vidal Quiana C. , David Moses A. , Wolfsberger James Gerard , Wimalarathne Madushika M. , Fowler Evann , Diaz John R. , Fink Alexis , Sterkel Elijah S. , Ross Ian , Vogler Bernhard , Love-Rutledge Sharifa T.
Published: July 2024

Characterizing changes in beta cell function during prolonged hyperinsulinemia and dietary stress is important to study to prevent diseases like metabolic dysfunction-associated steatotic liver disease and insulin resistance. This research investigates how a moderate sucrose (MS) diet affects insulin resistance and β-cell mass in two rat strains: LEW.1WR1 and Wistar Furth (WF). LEW.1WR1 rats seem to be sensitive to beta cell disruptions as weanlings. Twenty-one male LEW.1WR1 rats and sixteen male WF rats were studied over 18 weeks. The rats were divided into groups and given either the control or MS diet. Their body weight was monitored twice a week. Insulin tolerance tests (ITTs) and fasting blood glucose measurements were taken at intervals. Urine samples were analyzed to assess metabolic shifts, and pancreas tissue was examined to evaluate changes in β-cell mass. The LEW.1WR1 rats became overweight and showed higher insulin resistance than the WF rats. Both strains of rats on the MS diet displayed changes in urine metabolite profiles in terms of levels of lactic acid and alanine. This study highlights the impact or lack thereof of a moderate sucrose diet on body mass, insulin resistance, and β-cell mass, with notable effects observed specifically in LEW.1WR1 rats. These findings contribute to our understanding of how dietary sugar intake can affect metabolism when observed in models sensitive to metabolic defects.
Phenomenological Nondimensional Parameter Decomposition to Enhance the Use of Simulation Modeling in Fire Probabilistic Risk Assessment of Nuclear Power Plants
Authors: Alkhatib Sari , Sakurahara Tatsuya , Reihani Seyed , Kee Ernest , Ratte Brian , Kaspar Kristin , Hunt Sean , Mohaghegh Zahra
Published: July 2024

Simulation modeling is crucial in support of probabilistic risk assessment (PRA) for nuclear power plants (NPPs). There is a challenge, however, associated with simulation modeling that relates to the time and resources required for collecting data to determine the values of the input parameters. To alleviate this challenge, this article develops a formalized methodology to generate surrogate values of input parameters grounded on the decomposition of phenomenological nondimensional parameters (PNPs) while avoiding detailed data collection. While the fundamental principles of the proposed methodology can be applicable to various hazards, the developments in this article focus on fire PRA as an example application area for which resource intensiveness is recognized as a practical challenge. This article also develops a computational platform to automate the PNP decomposition and seamlessly integrates it with state-of-practice fire scenario analysis. The applicability of the computational platform is demonstrated through a multi-compartment fire case study at an NPP. The computational platform, with its embedded PNP decomposition methodology, can substantially reduce the effort required for input data collection and extraction, thereby facilitating the efficient use of simulation modeling in PRA and enhancing the fire scenario screening analysis.
Impact of Mandatory Audits of Small- and Medium-Sized Enterprises on Their Income Tax Compliance: Evidence from the Egyptian Small- and Medium-Sized Enterprise Stock Market
Authors: Mohamed Abouelghit Mahmoud Galal , Gan Shengdao
Published: July 2024

Small- and medium-sized enterprises are essential to the economies of nearly all countries, as they directly influence the GDP and tax revenue. In 2019, the European Federation of Accountants and Auditors for SMEs surveyed SME account users, revealing that tax authorities were the most common recipients of the company’s accounts, accounting for 61.40% of cases. This study, from a macroeconomic perspective, aims to uncover evidence of the impact of mandatory audits of Egyptian SMEs on their income tax compliance. It also seeks to explore the Egyptian SME tax environment to fill the knowledge gap by exploring perceptions of SMEs’ tax performances and their levels of tax. This study provides evidence that the taxpayers’ tax compliance behavior is an essential and decisive factor in the compliance of Egyptian SMEs with income tax. The results show that SME management is less persuaded by the potential benefits of mandatory audits on tax compliance than auditors and academics. Also, the study found experimental evidence confirming that the mandatory auditing of SMEs positively impacts their compliance with income tax. Additionally, this study developed a tax compliance scale (the RTRP scale) that effectively suits the nature and characteristics of SMEs, enabling the quantitative measurement of their compliance levels with income tax, as well as comparisons between SMEs.
Effect of Microencapsulated Cocoa Polyphenols on Macro- and Microvascular Function after Eccentric Exercise
Authors: de Oliveira Gustavo Vieira , Miranda de Souza Leonardo Victor , Junior Olavo João Frederico Ramos , Volino-Souza Mônica , Alvares Thiago Silveira
Published: July 2024

Background: Evidence has demonstrated that non-habitual exercise, such as eccentric exercise, can increase reactive oxygen species and induce endothelial dysfunction, which plays a central role in the development of cardiovascular disease. Polyphenol-rich foods, such as cocoa, have been widely investigated in vascular function due to their antioxidant effect. Aims: The goal of this study was to evaluate the impact of microencapsulated cocoa (MC) polyphenols in the flow-mediated dilation (FMD) response and forearm muscle oxygenation (StO2) parameters after an eccentric exercise. Methods: Thirteen physically active adults were enrolled in a randomized, double-blind, and crossover study. FMD and StO2 were evaluated before and after 24 h, 48 h, and 72 h of eccentric exercise and MC or placebo supplementation. Results: No significant difference in FMD response and StO2 parameters was observed after MC and placebo (p > 0.05). Conclusions: A single dose of MC did not change FMD and muscle StO2 parameters after eccentric exercise in healthy individuals.
Abraham General Solvation Parameter Model: Predictive Expressions for Solute Transfer into Isobutyl Acetate
Authors: Motati Ramya , Kandi Trisha , Francis Jilawan , Chen Jocelyn , Yao Emily , Motati Saikiran , Chen Audrey , Kumarandurai Dhishithaa , Shanmugam Nikita , Acree William E.
Published: July 2024

Mole fraction of solubilities are reported for the: o-acetoacetanisidide, anthracene, benzoin, 4-tert-butylbenzoic acid, 3-chlorobenzoic acid, 3-chlorobenzoic acid, 2-chloro-5-nitrobenzoic acid, 4-chloro-3-nitrobenzoic acid, 3,4-dichlorobenzoic acid, 2,3-dimethoxybenzoic acid, 3,4-dimethoxybenzoic acid, 3,5-dimethoxybenzoic acid, 3,5-dinitrobenzoic acid, diphenyl sulfone, 2-ethylanthraquinone, 2-methoxybenzoic acid, 4-methoxybenzoic acid, 2-methylbenzoic acid, 3-methylbenzoic acid, 2-methyl-3-nitrobenzoic acid, 3-methyl-4-nitrobenzoic acid, 4-methyl-3-nitrobenzoic acid, 2-naphthoxyacetic acid, 3-nitrobenzoic acid, 4-nitrobenzoic acid, salicylamide, thioxanthene-9-one, 3,4,5-trimethoxybenzoic acid, and xanthene dissolved in isobutyl acetate at 298.15 K. The results of our experimental measurements, combined with the published literature data, were used to obtain Abraham model equations for isobutyl acetate. The mathematical correlations presented in the current study describe the observed molar solubility ratios of the solutes dissolved in isobutyl acetate to within an overall standard deviation of 0.12 log units or less.
Investigation of Single Grain Grinding of Titanium Alloy Using Diamond Abrasive Grain with Positive Rake Angle
Authors: Yin Jiu , Sun Rushui , Ming Chuanbo , Chen Chang , Zeng Shuai
Published: July 2024

Traditional grinding, which is predominantly performed with a negative rake angle (NRA), can be transformed into grinding with a positive rake angle (PRA) by employing femtosecond pulsed laser technology to modify the apex angle of the grains to be less than 90°. This innovative approach aims to reduce grinding forces and grinding temperatures while improving the surface quality of typical hard-to-machine materials. To assess the performance of PRA single grain grinding and to investigate the underlying mechanisms, the finite element simulation software ABAQUS 6.14 was employed to model the grinding of Ti6Al4V titanium alloy with a single diamond abrasive grain. The dependence of grinding force and temperature in single grain grinding with a PRA or an NRA under different grinding parameters was studied and compared. PRA and NRA single diamond grain grinding experiments on Ti6Al4V alloy were carried out, with grinding forces measured using a dynamometer and compared with the simulation results. The grinding surface morphology and surface roughness were observed and measured, and a comparison was made between PRA and NRA grinding. The results indicated that in single diamond grain grinding, transforming to a PRA significantly enhances grinding performance, as evidenced by reduced grinding forces, lower temperatures, improved surface morphology, and decreased surface roughness. These findings suggest that PRA single diamond grain grinding offers substantial benefits for the precision machining of hard-to-machine materials, marking a step forward in optimizing surface finishes.
A Cognitive Load Theory (CLT) Analysis of Machine Learning Explainability, Transparency, Interpretability, and Shared Interpretability
Authors: Fox Stephen , Rey Vitor Fortes
Published: July 2024

Information that is complicated and ambiguous entails high cognitive load. Trying to understand such information can involve a lot of cognitive effort. An alternative to expending a lot of cognitive effort is to engage in motivated cognition, which can involve selective attention to new information that matches existing beliefs. In accordance with principles of least action related to management of cognitive effort, another alternative is to give up trying to understand new information with high cognitive load. In either case, high cognitive load can limit potential for understanding of new information and learning from new information. Cognitive Load Theory (CLT) provides a framework for relating the characteristics of information to human cognitive load. Although CLT has been developed through more than three decades of scientific research, it has not been applied comprehensively to improve the explainability, transparency, interpretability, and shared interpretability (ETISI) of machine learning models and their outputs. Here, in order to illustrate the broad relevance of CLT to ETISI, it is applied to analyze a type of hybrid machine learning called Algebraic Machine Learning (AML). This is the example because AML has characteristics that offer high potential for ETISI. However, application of CLT reveals potential for high cognitive load that can limit ETISI even when AML is used in conjunction with decision trees. Following the AML example, the general relevance of CLT to machine learning ETISI is discussed with the examples of SHapley Additive exPlanations (SHAP), Local Interpretable Model-Agnostic Explanations (LIME), and the Contextual Importance and Utility (CIU) method. Overall, it is argued in this Perspective paper that CLT can provide science-based design principles that can contribute to improving the ETISI of all types of machine learning.
Relationship between Lesion Parameters after Radiofrequency Catheter Ablation in Striated Muscles and Parenchymal Tissue
Authors: Gružienė Aldona , Liobikas Julius , Paparde Artūrs , Kerzienė Sigita , Gružaitė Jovita , Skaudickas Darijus , Lenčiauskas Povilas , Circenis Kristaps , Vaitiekaitis Gintautas
Published: July 2024

Background and Objectives: Radiofrequency catheter ablation (RFCA) is a highly successful intervention. By comparing the lesion changes in prostate parenchymal and striated muscle tissues after RFCA with and without cooling, it was possible to assess the correlation between the shape regularity, area, and perimeter of the thermal lesion, and to predict the geometric shape changes of the lesions. Materials and Methods: A standard prostate and striated muscle RFCA procedure was performed on 13 non-purebred dogs in two sessions: no cooling and cooling with 0.1% NaCl solution. Microtome-cut 2–3 µm sections of tissue samples were stained with haematoxylin and eosin and further examined. The quotient formula was employed to evaluate the geometric shape of the damage zones at the ablation site. Results: The extent of injury following RFCA in striated muscle tissue was comparable to that in prostate parenchymal tissue. Regression analysis indicated a strong and positive relationship between area and perimeter in all experimental groups. In the experimental groups of parenchymal tissues with and without cooling, an increase in the area or perimeter of the damage zone corresponded to an increase in the quotient value. A similar tendency was observed in the striated muscle group with cooling. However, in the striated muscle group without cooling, an increase in lesion area or perimeter lowered the quotient value. Standardised regression coefficients demonstrated that in the striated muscle with cooling, the damage zone shape was more determined by area than perimeter. However, in the parenchymal tissue, the perimeter had a more substantial impact on the damage zone shape than the area. Conclusions: The damage area and perimeter have predictive power on the overall shape regularity of damage zone geometry in both striated muscles and parenchymal tissue. This approach is employed to achieve a balance between the need for tumour eradication and the minimisation of ablation-induced complications to healthy tissue.
Ultrasound Imaging of Thoracolumbar Fascia: A Systematic Review
Authors: Pirri Carmelo , Pirri Nina , Macchi Veronica , Porzionato Andrea , De Caro Raffaele , Stecco Carla
Published: July 2024

Over the past decade, there has been a notable increase in research focused on ultrasound imaging of thoracolumbar fascia (TLF). Nevertheless, published papers’ results about the application of US imaging in TLF examination are still sparse. Background and Objevtives: Hence, this systematic review was performed aiming to firstly investigate the use and the methodology of ultrasound imaging to assess pathologic and healthy TLF. Secondarily, we aim to assess intra- and inter-observer reproducibility of US imaging in TLF assessment. Materials and Methods: The search was done on PubMed and Web of Science database from inception to April 2024. Furthermore, the references of included papers were thoroughly checked to find eligible publications. The MeSH keywords used were: “Thoracolumbar fascia”, “Ultrasound Imaging”, “Ultrasound”, “Ultrasonography”, and “Ultrasound examination”. Results: Studies were aimed primarily at TLF diagnosis, treatment monitoring, or evaluating movement-related changes, underscoring the diverse clinical applications. The US parameters assessed included TLF thickness, echogenicity, stiffness, deformation, shear strain, and displacement, providing comprehensive insights into TLF features. Conclusions: Advanced US imaging holds promise as a reliable tool in musculoskeletal assessment, offering insights into TLF pathology/disfunction, treatment outcomes, and movement dynamics.
Treatment of Unfavorable Intrabony Defects with Autogenous Bone Graft in Combination with Leukocyte- and Platelet-Rich Fibrin or Collagen Membranes: A Non-Inferiority Study
Authors: Balice Giuseppe , Paolantonio Michele , De Ninis Paolo , Rexhepi Imena , Serroni Matteo , Frisone Alessio , Romano Luigi , Sinjari Bruna , Murmura Giovanna , Femminella Beatrice
Published: July 2024

Background and Objectives: Unfavorable intrabony defects (IBDs) are associated with the progression of periodontal disease and tooth loss. Growing scientific evidence has demonstrated the effectiveness of platelet concentrations in periodontal treatment. The aim of our study was to demonstrate the non-inferiority of an autogenous bone graft (ABG) associated with leukocyte- and platelet-rich fibrin (L-PRF) compared to ABG + Collagen Membrane in the treatment of IBDs. Material and Methods: Sixty-four patients with at least one IBD were randomly assigned to two groups: ABG+L-PRF and CM+ABG. Clinical and radiographic evaluations were performed at baseline and 12-month follow-up. Clinical attachment level (CAL), gingival recession (GR), probing pocket depth (PPD), and radiograph defect bone level (DBL) were compared between the two treatments. To evaluate the effectiveness of ABG+L-PRF, a non-inferiority margin of =1 mm (−1 mm for GR) was chosen; a second non-inferiority margin of =0.5 mm (−0.5 mm for GR) was set for clinical relevance. Results: At 12-month follow up, both treatments showed clinical and radiographic improvements. The 90% confidence intervals of the CM+ABG–L-PRF+ABG mean difference for CAL gain (−0.0564 mm [−0.316 to 0.203]), DBL gain (−0.433 mm [−0.721 to −0.145]), and PPD reduction (0.232 mm [0.015 to 0.449]) were below the 0.5 mm non-inferiority margin; the GR increase (0.255 mm [0.0645 to 0.445]) stayed above the −0.5 mm. Conclusions: the L-PRF+ABG treatment of unfavorable IBDs is non-inferior with respect to the CM+ABG therapy for CAL gain, but with a lower GR, a slightly higher PPD, and DBL gain.
Conservative Treatment in Avascular Necrosis of the Femoral Head: A Systematic Review
Authors: Goncharov Evgeniy Nikolaevich , Koval Oleg Aleksandrovich , Nikolaevich Bezuglov Eduard , Aleksandrovich Vetoshkin Aleksandr , Gavriilovich Goncharov Nikolay , Encarnación Ramirez Manuel De Jesus , Montemurro Nicola
Published: July 2024

Introduction: Avascular necrosis (AVN) of the femoral head is a pressing orthopedic issue, leading to bone tissue death due to disrupted blood supply and affecting the quality of life of individuals significantly. This review focuses on conservative treatments, evaluating their efficacy as mainstay therapies. Enhanced understanding of AVN’s pathophysiology and advancements in diagnostic tools have rekindled interest in non-surgical interventions, emphasizing personalized, multidisciplinary approaches for improved outcomes. Material and Method: A systematic search was conducted on PubMed, SCOPUS, and Google Scholar databases from January 2020 to August 2023, with the objective of focusing on conservative treatments for AVN of the femoral head. Eligible studies, including original research, case reports, and observational studies, were examined for relevant, well-documented patient outcomes post-conservative treatments, excluding non-English and surgically focused articles without comparative conservative data. Results: A systematic search yielded 376 records on AVN of the femoral head across multiple databases. After de-duplication and rigorous screening for relevance and quality, 11 full-text articles were ultimately included for a comprehensive qualitative synthesis, focusing on conservatively managing the condition. Conclusions: This review evaluates the effectiveness of conservative treatments such as pharmacological interventions and physical modalities in managing AVN of the femoral head. Despite promising results in symptom alleviation and disease progression delay, variability in outcomes and methodological limitations in studies necessitate further rigorous, randomized controlled trials for a robust, patient-centric approach to optimize therapeutic outcomes in AVN management.
Overview of the Efficacy of Using Probiotics for Neurosurgical and Potential Neurosurgical Patients
Authors: Fijan Sabina , Šmigoc Tomaž
Published: July 2024

This review delves into the emerging field of the gut microbiota–brain axis, emphasizing its bidirectional communication and implications for neurological health, particularly in trauma and neurosurgery. While disruptions in this axis can lead to dysbiosis and hinder neurological recovery, recent studies have highlighted the therapeutic potential of interventions like probiotics in targeting this axis. This review aims to focus on the efficacy of probiotic supplementation to support the gut microbiota–brain axis in trauma, neurosurgery, or pain based on the current clinical trials to assess the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS). This comprehensive literature review identified 10 relevant publications on probiotic interventions for various neurosurgical conditions across multiple countries. These studies demonstrated diverse outcomes, with significant improvements observed in gastrointestinal mobility, inflammatory responses, and infection rates, particularly in post-traumatic brain injury and spinal surgery. Probiotics also showed promise in mitigating antibiotic-associated diarrhea and modulating inflammatory cytokines. Despite the promising findings, the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS) call for cautious interpretation. Conflicting outcomes emphasize the need for better-designed trials to understand strain-specific and disease-specific effects accurately. In conclusion, probiotics offer a promising adjuvant therapy for neurosurgical patients, traumatic brain injuries, and post-spinal surgery. However, further well-designed randomized controlled trials are essential to elucidate the intricate relationship between microbiome-modulating interventions and the CNS via the gut microbiota–brain axis.
Validity, Verifiability, and Confirmability: A Critique of Multiphase Packed Bed Modeling
Authors: Otarod Masood
Published: July 2024

The pseudocontinuum models of reactions in packed beds are complicated, and an assessment of the reliability of the predictability of their numerical solution is difficult. The predictability reliability depends on validity and verifiability, whereas the numerical solutions of models of reactions in packed beds cannot be validated or verified. Scientific acceptability cannot commence by metaphysics alone, and the truth of the speculative justifications of the results of the numerical models without robust empirical confirmation is a matter of chance occurrence. Adherence to the principles of noncontradiction and mathematical consistency seems to be the minimal criterion if a pseudocontinuum model is to demonstrate a degree of reliability in prediction, simulation, and design. This article is an exposition of the verifiability, validity, and confirmability characteristics of multiphase multidimensional models of reactions in packed beds. It addresses the difficulties of validation and the complexities of construction of models of reactions in packed beds by modeling kinetic data directly to show that often the claims of validity, verifiability, or confirmability of the results of multidimensional or even one-dimensional models of chemical reactions in packed beds, in spite of robust statistical tools, should be viewed with some degree of skepticism.
Development and Validation of Liquid Chromatographic Method for Fast Determination of Lincomycin, Polymyxin and Vancomycin in Preservation Solution for Transplants
Authors: Lin Qi , Nguyen Tam , Staffieri Chiara , Van Schepdael Ann , Adams Erwin
Published: July 2024

In this study, a liquid chromatographic method was developed for the fast determination of lincomycin, polymyxin and vancomycin in a preservation solution for transplants. A Kinetex EVO C18 (150 × 4.6 mm, 2.6 µm) column was utilized at 45 °C. Gradient elution was applied using a mixture of mobile phases A and B, both including 30 mM phosphate buffer at pH 2.0 and acetonitrile, at a ratio of 95:5 (v/v) for A and 50:50 (v/v) for B. A flow rate of 1.0 mL/min, an injection volume of 20 µL and UV detection at 210 nm were used. A degradation study treating the three antibiotics with 0.5 M hydrochloric acid, 0.5 M sodium hydroxide and 3% H2O2 indicated that the developed method was selective toward lincomycin, polymyxin, vancomycin and their degradation products. Other ingredients of the preservation solution, like those from the cell culture medium, did not interfere. The method was validated with good sensitivity, linearity, precision and accuracy. Furthermore, lincomycin, polymyxin and vancomycin were found to be stable in this preservation solution for 4 weeks when stored at −20 °C.
The Impact of Plant Additives on the Quality and Safety of Ostrich Meat Sausages
Authors: Woźniak Łukasz , Porębska Izabela , Świder Olga , Sokołowska Barbara , Szczepańska-Stolarczyk Justyna , Lendzion Krzysztof , Marszałek Krystian
Published: July 2024

Ostrich meat is an interesting alternative to poultry or beef due to its nutritional value. The addition of three plant species (hot peppers, acerola, Schisandra chinesis) was suggested as a method to improve the quality, safety, and consumer acceptance of sausages prepared from ostrich meat. A series of microbiological and chemical analyses (including, inter alia, content of biogenic amines, heavy metals, and bioactive compounds) of the products as well as their sensory evaluation was performed to verify this claim. The microflora of all sausages was dominated by lactic acid bacteria. The biggest threat to consumers’ health could be connected to the presence of biogenic amines formed through the enzymatic activity of lactic acid bacteria. The sausages with plant additives had better antioxidative and anti-inflammatory properties and lower fat oxidation—these features were correlated with the presence of vitamin C. Sausages with plant additives had a higher acceptability in terms of taste and smell.
Effect of Temperature on CO2 Adsorption onto Amine-Functionalized KIT-6 Adsorbents
Authors: Suba Mariana , Verdeș Orsina , Borcănescu Silvana , Popa Alexandru
Published: July 2024

The mesoporous silica KIT-6 was synthesized and functionalized with 3-aminopropyltriethoxysilane (APTES) by grafting at 110 °C. The composites were prepared with three different concentrations of APTES: 20, 30 and 40 wt.%. The as-prepared samples were characterized by thermal gravimetric analysis in air and nitrogen atmosphere (TG/DTA), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction and nitrogen adsorption–desorption. In this study, CO2 adsorption–desorption was investigated using temperature programmed desorption mass spectrometry (TPD-MS) at different temperatures. The adsorption capacity of the prepared composites is 2.23 mmol CO2/g at 40 °C and decreases to 0.95 mmol/g at 70 °C. Regarding the efficiency of the amino groups, the best result was obtained for APTES-grafted KIT-6 at 40 °C, with 0.512 mmol CO2/mmol NH2. The results showed good cyclical stability in adsorption capacities even after nine adsorption–desorption cycles.
The Impact of Phospholipid-Based Liquid Crystals’ Microstructure on Stability and Release Profile of Ascorbyl Palmitate and Skin Performance
Authors: Zvonar Pobirk Alenka , Roškar Robert , Bešter-Rogač Marija , Gašperlin Mirjana , Gosenca Matjaž Mirjam
Published: July 2024

The drug delivery potential of liquid crystals (LCs) for ascorbyl palmitate (AP) was assessed, with the emphasis on the AP stability and release profile linked to microstructural rearrangement taking place along the dilution line being investigated by a set of complementary techniques. With high AP degradation observed after 56 days, two stabilization approaches, i.e., the addition of vitamin C or increasing AP concentration, were proposed. As a rule, LC samples with the lowest water content resulted in better AP stability (up to 52% of nondegraded AP in LC1 after 28 days) and faster API release (~18% in 8 h) as compared to the most diluted sample (29% of nondegraded AP in LC8 after 28 days, and up to 12% of AP released in 8 h). In addition, LCs exhibited a skin barrier-strengthening effect with up to 1.2-fold lower transepidermal water loss (TEWL) and 1.9-fold higher skin hydration observed in vitro on the porcine skin model. Although the latter cannot be linked to LCs’ composition or specific microstructure, the obtained insight into LCs’ microstructure contributed greatly to our understanding of AP positioning inside the system and its release profile, also influencing the overall LCs’ performance after dermal application.