bluuebunny/crossref_metadata_2025 huggingface dataset:
ÖSSZEFOGLALÓ A „KREATIVITÁS – ELMÉLET ÉS GYAKORLAT” KONFERENCIÁRÓL
Authors: Mező Katalin
Published: December 2022

2022. december 9-én került megvalósításra a „Kreativitás – Elmélet és Gyakorlat (2022) Nemzetközi Interdiszciplináris Online Konferencia. A konferencián 5 ország 126 résztvevőjének 95 előadása lett közzé téve 8 szekcióban.
HÁTRÁNYOK ÉS TÁMOGATÁSOK: A SZOCIÁLIS ELLÁTÓRENDSZER HELYE ÉS SZEREPE A FOGYATÉKOSSÁGGAL ÉLŐK ÉS CSALÁDJAIK ÉLETÉBEN
Authors: Balázs-Földi Emese
Published: December 2022

2011-es népszámlálási adatok szerint a fogyatékossággal élő személyek nagyobb aránya magánháztartás-ban, míg kisebb részük intézeti ellátásban él. 62 ezer fölé tehető azoknak a családoknak a száma, ahol fogyatékossággal élő gyermek nevelkedik. Kutatási eredmények rávilágítanak, hogy a fogyatékossággal élő családtag ellátása, gondozása különösen nagy terhet ró a családokra. A szociálpolitikai eszközök jelentős szerepet játszanak az érintett társadalmi csoport terheinek csökkentésében. Jelen tanulmányban áttekintést nyújtunk a fogyatékossággal élő emberek és az őket gondozó családok mindennapi életét segítő szociális ellátások és szolgáltatások rendszeréről. Bemutatjuk, jelenleg milyen szociálpolitikai eszközökkel támogatják a fogyatékos személyeket és az őket gondozó családokat. Választ keresünk arra, hogy a jelenleg elérhető szociálpolitikai eszközök elősegítik-e a fogyatékos személyek, illetve családtagjaik társadalmi részvételének, integrációjának megvalósulását.
FOGYATÉKOSSÁG AZ ORVOSTUDOMÁNYBAN
Authors: Pető Ildikó , Gere Hajnalka
Published: December 2022

Jelen tanulmány egy két részből álló tanulmánypár első eleme, melyben az orvostanhallgatók, az orvosok, az orvostudomány és a fogyatékosságok, fogyatékos személyek kapcsolatának az alakulását vizsgáljuk. Bemutatásra kerülnek a fogyatékos személyek megítélését befolyásoló tényezők a különböző történelmi korokban, különböző modellek alapján, továbbá orvostudományi szempontok szerint elemezzük a gyógypedagógia kialakulását. Röviden kifejtjük az orvosképzés történetét, valamint, hogy milyen szerepet töltenek be a fogyatékossággal kapcsolatos ismeretek a medikusok egyetemi évei alatt. Jelen áttekintés elméleti alapját képezi egy, a későbbiekben megjelenő vizsgálati alapú elemzésünknek, melyben a medikusok személyes és szakmai válaszaik alapján elemeztük a fogyatékosok csoportjairól alkotott véleményüket, ismereteiket, kórházi tapasztalataikat.
TÉRSZEMLÉLETFEJLESZTÉS A MATEMATIKA ÓRÁKON 11-12 ÉVES GYEREKEK KÖRÉBEN
Authors: Nagy Lehocky Zsuzsa , Szabó Tibor
Published: December 2022

A kisiskolás gyerekek térszemléletének fejlesztése az oktatási folyamat fontos feladata, különös tekin-tettel a megszerzett kompetenciák gyakorlati alkalmazása a valós életben. A tanulmányban röviden bemutatjuk a 11-12 éves tanulók térszemlélet fejlesztésére fókuszáló projektünkben alkalmazott fejlesztő feladatokat, melyek a matematika órákon valósultak meg. A tanulók olyan feladatokat oldottak meg, amelyek a sík és térbeli tárgyakkal való problémamegoldásra, a sík vagy térbeli helyzetek elemzésére és a tárgyakkal való manipulálására összpontosítottak.
LOVÁRI NYELV “INTÉZMÉNYESÜLÉSE” A TÁRSADALMI INNOVÁCIÓ APSEKTUSÁBÓL
Authors: Tóth Norbert
Published: December 2022

Jelen tanulmányban a társadalmi innováció perspektívájából, a lovári nyelvoktatás történetiségire és társadalmi hatására vagyunk kíváncsiak. Kiindulópontunk, hogy a lovári nyelv elfogadtatásának és az idegen nyelvek oktatási palettáján való elismertetésének folyamata, egy ”alulról” induló, elsősorban roma értelmiségiek munkájából kibontakozó kezdeményezés. Érdeklődésünk fókuszában többek között a következő kérdések állnak: Ki találta ki? Ki támogatta? Ki akadályoztatta? Milyen nyelvtanulási módszereket alkalmaznak a lovári nyelvet oktató, nem nyelvtanár végzettségű emberek? A lovári nyelvoktatás „intézményesülése”, s ebből a nyelvből megszerezhető államilag elismert nyelvvizsga bizonyítványnak komoly társadalmi hatása van, példának okán, elősegítette a hátrányos és/vagy roma származású tanulókat az egyetemi diploma megszerzéséhez. Ebből a szempontból ezt is egy innovációnak tekintjük. A témát a szekunder források mellett, primer, kvalitatív adatok segítségével kívánjuk feltérképezni. Több évtizede oktató lovári nyelvtanárokkal (N=3) készített interjúk mellett, a saját percepcióinkat szeretnénk narratívába foglalni.
The Relationship between Compassion Satisfaction and Fatigue with Shift Nurses’ Patient Safety-Related Activities
Authors: Ryu I Seul , Shim Jae Lan
Published: December 2022

Background: We examined the relationships of compassion satisfaction and fatigue among shift nurses on nursing engagement activities related to patient safety with the aim of improving shift nurses’ physical and psychological aspects in order to use the findings as a basis to enhance nurses’ engagement in activities related to patient safety.
Methods: The data collection period for this cross-sectional study was from Nov 21, 2019, to Jan 3, 2020. A convenience sample of 280 shift nurses who were working for more than six months at three tertiary hospitals in Korea was used. Collected data comprised general and job-related characteristics of subjects, compassion satisfaction, compassion fatigue, and patient safety nursing activities. SPSS was used for statistical analysis, and multiple regression analysis was used to examine the relationship between shift nurses' compassion satisfaction, compassion fatigue, and patient safety nursing activities
Results: Compassion satisfaction had the greatest impact on engagement in nursing activities related to patient safety (β= .32, P<.001), followed by compassion fatigue. Higher compassion satisfaction and lower compassion fatigue indicates a higher engagement in patient safety-related nursing activities (β= -.15, P<.008).
Conclusion: In order to maximize compassion satisfaction and reduce compassion fatigue among shift nurses, it is important for health policymakers to improve their welfare system and create a supportive environment where negative emotions can be expressed freely and accepted positively.
Evaluation of Antibiotic Resistance and adeABC, adeR, adeS Efflux Pump Genes among Foodborne and Clinical Acinetobacter spp. in Türkiye
Authors: Terkuran Mevhibe , Erginkaya Zerrin , Konuray Gözde , Meral Melda , Ünal Nevzat , Sertdemir Yaşar , Köksal Fatih
Published: December 2022

Background: The adeABC efflux pump has a crucial role in the resistance of Acinetobacter baumannii strains to antimicrobial agents; it is encoded by adeABC, adeR, adeS genes. We evaluated antibiotic resistance, efflux pump genes, clonal relationships, and analyzed a probable correlation that can exist between antibiotic resistance and the aforementioned genes.
Methods: We conducted this study on 27 food-originated and 50 human clinical Acinetobacter spp. in Southern Türkiye. MALDI-TOF system and disc diffusion/agar dilution (colistin) methods were used for the identification and antibiotic susceptibility. The efflux pump genes and genetic relatedness of the two groups were investigated by (PCR) and (PFGE) methods.
Results: Foodborne A. dijkshoorniae strain was multidrug- resistant (MDR), and none of them resistant to colistin. Most of the clinical isolates (92%) were Extensive-Drug Resistant (XDR); highest resistant to ceftazidime, piperacillin-tazobactam, and imipenem (47, 94%), and were lowest to colistin (7, 14%), respectively. adeABC, and adeR, adeS genes were (23, 85.2%), (9, 33.3%), (27, 100%) and (10, 37.3%), (18, 66.7%) in foodborne strains respectively. These rates were (43, 86%), (48, 96%), (50, 100%), and (34, 68%), (48, 96.7%) in clinical strains respectively. A positive correlation existed between adeA gene positivity and piperacillin-tazobactam, ceftazidime, gentamycin, imipenem (P=0.048), amikacin (P=0.007) and trimethoprim-sulfamethoxazole (P=0.029) resistance in clinical strains. A positive correlation of trimethoprim-sulfamethoxazole resistance and adeS gene positivity was seen in foodborne strains (P=0.018).
Conclusion: Multiple-efflux pump genes rise in parallel to multidrug-resistance in clinical isolates, while susceptible to diverse antibiotics; food may be a potential provenance for the dissemination of adeABC, adeR and adeS genes.
Evaluation of Chitosan Nanoparticle Antimicrobial Effect on Isolated Listeria monocytogenes Bacteria from Pregnant Women and L. monocytogenes ATCC 7644
Authors: Rad Sara Kazemi , Assmar Mehdi , Mirpour Mirsasan , Razavi Mohamad Reza
Published: December 2022

Background: Listeria monocytogenes is a gram positive, facultative intracellular bacteria and it is a causative agent of listeriosis. Abortion is one the most important side effect of listeriosis. Nano chitosan is widely used as nanomaterials considered due to its characteristics such as bactericidal and nontoxicity activity. The aim of this study was isolation of L. monocytogenes bacteria from pregnant women vaginal samples and evaluation of chitosan nanoparticles effects against them.
Methods: Overall, 100 vaginal specimens were collected from pregnant women with and without a history of abortion referred to Tehran's Hospitals from Sep 2019 to Jul 2020 with questionnaires. Then, using biochemical methods, L. monocytogenes bacteria were isolated and identified. Isolated L. monocytogenes strains were confirmed using PCR and evaluation of prfA gene, which is the main gene for identification of this bacterium. The effect of chitosan nanoparticles was evaluated in comparison with the antibiotics used based CSLI guideline on isolated bacteria by well diffusion method. MIC and MBC were determined for nanoparticle at the end.
Results: Five strains of L. monocytogenes that were confirmed by PCR method. Moreover, a statistically significant relationship was observed between the isolated strains and the samples taken from women with a history of abortion. MIC and MBC for L. monocytogenes ATCC 7644 were 156.25 and 312.5 μg/ml and for 5 isolated strains were 78.12 and 158.25 μg/ml, respectively.
Conclusion: L. monocytogenes could be a causative agent of abortion in pregnant women. Concerning the results, Nano chitosan has acceptable antibacterial activity against L. monocytogenes.
The Expression Levels of Circulating miR-129 and miR-203a in Association with Breast Cancer and Related Metastasis
Authors: Ghalkhani Esmat , Akbari Mohammad Taghi , Izadi Pantea , Mahmoodzadeh Habibollah , Kamali Fatemeh
Published: December 2022

Background: A significant part of deaths related to breast cancer is the result of invasion to other organs. It is essential to discover new non-invasive biomarkers to improve anticipation of recurrence risk in breast cancer patients. In this study, the plasma levels of miR-129 and miR-203a were evaluated to investigate their diagnostic potential in breast cancer and its metastasis.
Methods: In this case-control study, conducted in Tarbiat Modares University, Tehran, Iran, in 2019, Invasive Ductal Carcinoma blood samples were divided into 3 groups based on their stages as I, II/III, IV. Each group contained 30 individuals. We also recruited 30 normal individuals as a control group. Real-Time PCR was conducted to evaluate miR-129 and miR-203a expression levels. The discriminatory ability of the evaluated plasma miRNAs was assessed by ROC (Receiver Operating Characteristic) curves in breast cancer diagnosis and its metastasis.
Results: MiR-129 and miR-203a expression levels were significantly downregulated in breast cancer. Reducing tendency was observed in the mentioned miRNAs from less to more invasive stages. The expression level of miR-129 was decreased in metastatic than non-metastatic patients and it was significantly related to metastasis. A significant association between miR-129 expression level and lymph node status was also observed (P=0.04). Evaluation of ROC curves revealed that miR-129 and miR-203a were able to discriminate breast cancer fairly and poorly respectively. The ability of miR-129 in the diagnosis of breast cancer metastasis was poor.
Conclusion: MiR-129 and miR-203a may both act as tumor suppressor miRNAs. Our results need further evidence in a large population to be confirmed as diagnostic markers.
How Can Private Resources Help Society in a Health Crisis? Evidence from Vietnam
Authors: Tung Le Thanh
Published: December 2022

The Article Abstract is not available.
Comparing Genetic Information of Severe Acute Respiratory Syndrome Corona Virus 2 and SARS CoV and Middle East Respiratory Syndrome Corona Viruses; A Review Study
Authors: Agharezaee Niloofar , Forouzesh Flora
Published: December 2022

Background & Objective: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global infection and a continuing pandemic. Symptoms have been associated with age, biological sex, and other previous present health situations. The aim of this study was to make a genetic comparison between the SARS-CoV-2, SARS-CoV, and Middle East Respiratory Syndrome (MERS)-CoV using phylogenetic methods.
Materials & Methods: In this review study, previously published papers were collected from 2010 to 2020 using electronic sources in reliable databases such as Scopus, PubMed, ISI, Google Scholar, and Science Direct. Then, we performed the bioinformatics study. For sequences alignment, analysis, and phylogenetic construction, all sequences from SARS-CoV-2, SARS-CoV, and MERS-CoV were obtained from the GeneBank database.
Results: Eighty percent of SARS-CoV and 50% of MERS-CoV RNA sequences shared with SARS-CoV-2 RNA and SARS-CoV-2 show additional genomic regions. The phylogenetic analysis of the full-length genome sequence shows that SARS-CoV-2 has the highest similarity with SARS-CoV, but it has a lower similarity with MERS-CoV. Considering the close relationship between SARS-2 and SARS, the examination of the amino-corrosive translocation of completely different proteins may prove that there are fundamental and utilitarian differences between SARS-2 and SARS.
Conclusion: Although COVID-19 pathogenicity is not well known, MERS-CoV and SARS-CoV pathogenesis still can be the best source of COVID-19 information. The global effect of this new epidemic is yet uncertain. So, analyzing genome sequencing is important for epidemiological, clinical, and experimental studies.
Hsa-miR-662 as a New Prognostic Biomarker in Patients with Breast Cancer; In-silico and Experimental Study
Authors: Foruzandeh Zahra , Alivand Mohammadreza , Ghiami Rad Mehdi , Zaefizadeh Mohammad , Ghorbian Saeid
Published: December 2022

Background & Objective: Breast cancer (BC) is a complex genetic disease that has an average annual incidence of one million people and is the second leading cause of death among women in the world. Therefore, a better understanding of tumor biology and the determination of biomarkers for early diagnosis of disease is essential. MicroRNAs and long non-coding RNAs are novel gene regulators that play key roles in tumor initiation and progression. The current study was performed to assess the biomarker potential. This study performed a combination of in-silico and experimental investigations of altered miRNAs in BC to assess the use of miRNAs as novel biomarkers for early detection and prognosis prediction of patients with BC.
Materials & Methods: We searched the miRNA expression patterns of BC from three expression arrays (GSE58606, GSE38867, and GSE40525) from the Gene Expression Omnibus (GEO) database to recognize differentially expressed miRNAs (DEMs) between BC tissues and normal adjacent samples. Using “Limma” package’s Quantile Normalization function and INMEX bioinformatic tool, hub DEMs were identified. MiRNAs targeted genes were found and visualized via the miRWalk and miRTargetLink databases and their Enrichment analysis was performed for identified genes. Due to more validation of DEGs, GSE70951, an independent expression array dataset, was analyzed. By merging DEMs and DEGs, miRNA-mRNA network was constructed. After elucidation of hub miRNAs, the capacity of detected miRNAs to differentiate BC from adjacent controls was estimated by Kaplan-Meier analysis. Furthermore, RT-qPCR on 100 BC samples and 100 adjacent non-tumor tissues was performed to validate the in-silico results.
Results: According to our study, in BC samples, miR-662 was differentially downregulated in comparison with normal adjacent tissues.
Conclusion: Altogether, miR-662 can be considered as a viable target for BC diagnostics and treatment.
Evaluation of AURKA rs2273535 and CDKN1B rs34330 Polymorphisms Association with the Risk of Breast Cancer
Authors: Liravi Atefeh , Houshmand Seyed Massoud , Jafarnia Mojtaba , Forouzanfar Mohsen
Published: December 2022

Background & Objective: Breast cancer consists of a heterogeneous group of tumours with different prognosis and is the most common cause of cancer-related mortality among women. In this study, our goal was to evaluate the association of AURKA rs2273535 and CDKN1B rs34330 polymorphisms with risk of female breast cancer in southwest part of Iran.
Materials & Methods: This case-control study was done on 50 women with breast cancer and 50 healthy women without any symptoms or family history of breast cancer as the case and control group, respectively. Restriction fragment length polymorphism (RFLP- PCR) technique was designed to determine the AURKA rs2273535 and CDKN1B rs34330 gene polymorphisms. Afterwards, statistical analysis was done by means of SPSS (version 17).
Results: In current research, our finding showed that rs2273535 T allele increased the susceptibility of breast cancer (OR:2.58, 95%CI:1.5-31.09, P=0.006). Moreover, T allele in dominant phase could raise the risk of the breast cancer (OR:3.01, 65%CI:1.31-6.92, P=0.009). However, the other polymorphism, CDKN1B rs34330, revealed no associations with increased risk of breast cancer.
Conclusion: These findings suggest that AURKA rs2273535 may influence individual’s susceptibility to breast cancer. But we found no associations regarding CDKN1B rs34330 polymorphism and this type of cancer.
Multiple Locus Variable-Number Tandem Repeat Analysis Genotyping of Human Brucella melitensis Isolates from West of Iran
Authors: Rahimi Heidar , Rashidian Ehsan , Shams Nemat , Jaydari Amin
Published: December 2022

Background & Objective: Brucellosis is an endemic disease with a high prevalence in Iran whose highest frequency is in the western region of the country. Genetic diversity investigation is an important method to determine the epidemiological relationship of Brucella isolates in different geographical areas. Therefore, the present study aimed to investigate the genetic diversity of human Brucella melitensis (B. melitensis) strains using the Multiple Locus Variable-Number Tandem Repeat Analysis (MLVA) Typing method in the west of the country.
Materials & Methods: In this study, 20 strains of isolated B. melitensis were collected from the human serum samples of suspected Brucellosis in the west of the country and were analyzed by MLVA-16 method.
Results: The results showed that 3 genotype numbers 42, 43 and 47 were identified using MLVA-8 method and using MLVA-11 method genotypes 125, 138 and 111 were recognized. Also, 16 different genotypes were detected from the analysis of the isolates by MLVA-16 method which shows a high degree of polymorphism among the isolates due to the high genetic diversity of the isolates in Panel 2B loci.
Conclusion: The results showed the high genetic diversity of B. melitensis isolates in the west of the country and their genetic relationship with the known strains in the neighboring countries of the Eastern Mediterranean area, as well as the importance of the MLVA method in identifying the source of infection.
Formulation and Physical Characterization of Sunflower Oil Nano Emulsion Containing Cinnamon Bark Extract
Authors: Ega Priani Sani , Peni Fitrianingsih Sri , Syafnir Livia
Published: December 2022

This research developed a sunflower oil nano emulsion containing cinnamon bark extract. Cinnamon bark contains many bioactive compounds that provide various pharmacological benefits, including antioxidant properties. The bark extract, when developed into a nano emulsion system using sunflower oil, improves the antioxidant property. The maceration method using ethanol 95% was used to extract the cinnamon bark and then further developed into the nano emulsion system using between 80 as surfactant and PEG 400 as cosurfactant. The optimum nano emulsion formula contains 4% sunflower oil, and 30% PEG 400. The sunflower oil nano emulsion is transparent, with a globule size of 102 ± 32 nm. The optimum formula of cinnamon bark nano emulsion was achieved with 0.25% extract. This shows good physical characteristics and stability.
Keywords: nanoemulsion, cinnamon bark, sunflower oil
Ginger Village: A Step Towards a Healthier Society
Authors: Lestari Fetri , Lukmayani Yani , Aryani Ratih , Mulkiya Yuliawati Kiki
Published: December 2022

The COVID-19 pandemic has been challenging for health, economic, and social conditions in Indonesia. There is a need to educate people to maintain and improve physical health. This includes the use of supplements and herbs as a method of prevention against diseases. Ginger has been proven to be an effective preventive and therapeutic agent. It is analgesic, anti-inflammatory, antiemetic, antioxidant and an immunomodulator. A community program was conducted to educate the public on the benefits of ginger and other supplements and herbs, to actively cultivate ginger plants and to produce products based on ginger. It was conducted in Ginger Village, Karasak Ward, Astanaanyar Subdistrict, Bandung City. The program consisted of seminars about the benefits of supplements and herbs, training to produce ginger drinks at home, and a donation of a hundred ginger plants to Karasak Ward society.
Keywords: ginger, health supplement, community service
Exploring Anticancer Potential in Bajakah Tampala by In Silico Virtual Screening
Authors: Tejasari M. , Respati T. , Yuniarti L.
Published: December 2022

Incidences of cancer have increased sharply throughout the world. The process of finding a targeted cancer drug takes a long time and a lot of money. One method that can help overcome this is computational methods, such as virtual screening. It can be an important alternative in early-stage drug discovery. The aim of this study is to explore and analyze the potential protein targets of Bajakah tampala (Spatholobulus littoralis) as an anticancer chemotherapy. This is a bioinformatics study that uses the in silico method through the pathway analysis method with PubChem software, Swiss Target prediction, String and Cytoscope. The results showed that many phytochemicals present in Spatholobulus littoralis Hask are predicted to be anticancer.
Keywords: Anticancer, Bajakah tampala, In silico, Spatholobulus littoralis
The Development of Modular and Re-Usable Face Shields for COVID- 19 Prevention in Clinics
Authors: A. Yulianto F. , Nurrahman A. A. , Rejeki Y. S. , As'ad N. R. , Amrullah E. , Nurhalim M. , A. Shakira M. , M. Ibrahim M.
Published: December 2022

COVID-19 continues to cause a high fatality rate - especially in health workers. Safety protocols in nearly all aspects of our lives were announced to minimize the spread of the disease. A common personal protection equipment (PPE) that is used as a safety precaution is the face shield, a portable barrier to protect human to human transmission. Unfortunately, this simple, mass-produced device has not been made in a standardized way. This study aimed to create a standard modular and ergonomic face shield that can be dispatched, recleaning, sterilized, and partially renewed. Polyethylene Terephthalate (PET) and Polylactide (PLA) filaments were selected as the materials to be used. PETs with 0.3 mm thickness were used for the visor. The headband was designed in AutoCAD 2019 then produced by a Flashforge 3D printer. Nurses’ anthropometric measurement was used as guidance in formulating the size of the head band. 60 head bands were produced in 2 months of 5 working days (80 minutes for each headband). This device was given to non-government clinics that have short PPE supplies and was evaluated according to their reliability and comfort. We concluded that this new PPE had minimum visual distortion, was easy to dismount, and easy to replace, except for the headband.
Keywords: covid-19, face shield, prevention
The Effect of Lavender Inhalation on the Pain Perception of Orthodontic Separator Placement: An Open-Label Randomized Controlled Trial
Authors: Tazarvifard Shirazi Maryam , Karandish Maryam
Published: December 2022

Lavandula angustifolia Mill. (lavender) is known for its antibacterial, muscle relaxant, antispasmodic, sedative, and anesthetic effects, and is also proposed to be used as an analgesic agent. Despite several studies on the analgesic activity of lavender, this is the first experiment in patients with orthodontic pain. This "2-arm parallel" study aims to evaluate the effect of lavender oil inhalation on reducing pain after elastomeric separator placement as a part of orthodontic treatment. Patients who needed elastic separator placement in mesial and distal of first permanent molars of all quadrants prior to their first-ever fixed orthodontic treatment, with the age range of 20 to 24, were randomly assigned to one of the two study groups: lavender oil and sesame oil. Participants had to breathe in their medication for 2 minutes just before separator insertion, as well as 4, 8, 12, 24, 36, and 48 h afterward. A visual analog scale (VAS) was used to measure the level of pain during three oral situations, including rest, fitting posterior teeth, and chewing at the following periods: just before separator placement (T0), immediately after insertion (T1), 3 h post-insertion (T2), 12 h post-(T3), 24 insertion h post-insertion (T4), and 48 h after separator placement (T5). The current study indicated the effectiveness of lavender oil inhalation in reducing pain perception while chewing 48 h after elastic separator placement. The pain level in lavender inhalation was lower from 12 h to 48 h after separator insertion, although not considerable, indicating the probability of its effectiveness on delayed responses to orthodontic pain.
The I-CAM-IR: Persian Translation, Cross-Cultural Adaptation and Revised Version of the I-CAM-Q
Authors: Rostami Chijan Mahsa , Salehi Mehdi , Ostovar Mohadese , Haghjoo Elham , Sedigh Rahimabadi Massih , Hashempur Mohammad Hashem
Published: December 2022

Complementary and alternative medicine (CAM) has shown increasing acceptance, popularity, and use all around the world. The International Complementary and Alternative Medicine Questionnaire (I-CAM-Q) was developed to be a standard research instrument for achieving more reliable data and enabling researchers for comparing multiple studies on CAM use. This study aimed to provide a Persian translation of I-CAM-Q that also was adapted according to Iranian culture. The I-CAM-Q was translated and back-translated to Persian by a team of 2 translators and 2 traditional Persian medicine specialists. Then an internet-based specialist survey and an experts’ panel using the DELPHI method were done to perform cross-cultural adaptation. The feasibility study of the Iranian version of I-CAM-Q (i.e., I-CAM-IR) was tested upon adult population, the final changes were done to I-CAM-IR and data were gathered from 301 hypertensive patients. The related specific words such as traditional Persian medicine and “Attar” (herbalist) were added to the questionnaire for a more precise local adaptation. Meanwhile, some structural changes were made in the first two pages of the original I-CAM-Q and the questions about disclosure were added to it. This questionnaire was easily accepted by most patients during the interview. Generally, 72.4% of our hypertensive participants used CAM but only 41.8% of them disclosed this to their physicians. I-CAM-Q is a standard questionnaire that needs to be adapted to non-English speaking countries. Generally, in this study the useage of CAM among people with hypertention was high. Therefore, it is emphesised that physisians should have adequate knowledge about it. Meanwhile, conducting multicentral researches in this field will provide the basis for accumulative data about CAM use in Iran.
FLORA OF ODESA AIRPORT FOREST PARK
Authors: Gerasimiuk V. P. , Gerasimiuk N. V.
Published: December 2022

Introduction. The flora of the area of study included algae, fungi, lichens and higher plants (mosses, ferns, golonasinny and angiosperm). They play an important role in the ecosystem of the Airport Forest Park. Odesa, create primary organic matter, emit oxygen, dispose of carbon dioxide, enrich the soil with nitrogen substances, decompose the remains of organic substances and process them into inorganic and are food and shelter for many invertebrates (worms, mollusks, insects) and vertebrates (reptiles, birds, mammals) organisms.
Aim. The purpose of the work was to study the floristic diversity of the Airport Forest Park in Odessa.
Methods. For the first time, the flora of the Airport forest was investigated during 2000-2022 by the route method. Determination of the species composition of algae, fungi, lichens, higher plants was carried out by light microscopy with the help of  many determinists, atlases, monographs.
Results. The flora of the forest park "Airportivsky" consists of 173 species (173 inland species taxa), which belonged to 156 genera, 60 families, 37 orders, 13 classes, 10 departments, 4 kingdoms and 2 empires (domains). The flora consisted of lower (Thallophyta) and higher (Embryophyta) plants. Lower plants were represented by algae (12 species), fungi (35) and lichens (2), higher – mosses (3), ferns (1), golonosin (6) and angiosperms (114). A characteristic feature of the taxonomic diversity was the dominance of angiosperms (114 species) in the species composition of the flora of the forest park. The most represented species were the leading families Asteraceae (20 species), Rosaceae (13), Fabaceae (11), Brassicaceae (6), Poaceae (5), Oleaceae (5), Aceraceae (4), Fagaceae (2), Lamiaceae (2) and Plantaginaceae (2). Leading genera of Aser l. (4 species), Artemisia L. (4), Agaricus L. (3), Medicago L. (3), Prunus L. (3), Trifoilium L. (3), Closterium Nitsch ex Ralphs (3), Amanita Pers. (2), Lactarium Pers. (2) and Plantago L. (2) formed the basis of the flora of the forest park. The most interesting floral finds are found in the flora of the park of the following species: closterium closteroid (Closterium closterioides (Ralfs) Luns et Peweters), glass Ola (Cyathus olla (Batsch) Pers.).
Conclusions. For the first time in the flora of the Airport forest found 173 species (173 inland species taxa), belonging to 156 genera, 60 families, 37 orders, 13 classes, 10 divisions, 4 kingdoms and 2 empires (domains). Among them were found 12 species of algae, 35 fungi, 2 lichens, 3 mosses, 1 fern, 6 gymnosperms and 114 species of angiosperms.
ENDURANCE AND INTOXICATION INDICATORS OF RAT BRAIN WITH CHRONIC ALCOHOLIZATION
Authors: Makarenko О. А. , Karabadzhak L. I. , Кіка V. V.
Published: December 2022

Introduction. One of the current important and unsolved problems of modern medicine is revealing the nature of the impact of chronic alcohol intoxication on functional indicators of life. It is important to analyze the metabolic shifts caused by ethanol, as well as to findeffectiveways to prevent and correct the effectsof alcohol.
Aims. Research the effectof chronic ethanol consumption on endurance of rats, and determination of indicators of inflammation,intoxication and nonspecificresistance in the brain of laboratory rats.
Materials and Methods. The experiment was performed on 2-month-old male and female rats. Alcohol intoxication was reproduced by introducing ethanol into drinking water, starting with 5% and gradually increasing to 15%. Intact groups of males and females received water. Endurance of rats was assessed once a week by the Porsolta Behavioral Despair Test, in which rats were given negative buoyancy by additional weight. The time of endurance of rats served as an indicator of fatigue. The duration of the experiment constituted 108 days. Inflammation(elastase, acid phosphatase activity), intoxication (urease activity and malonic dialdehyde activity), nonspecificresistance (lysozyme and catalase activity) were determined in the brain.
Main results. It was found that the exercise stress contributes to the formation of more pronounced endurance of females than males. Chronic administration of ethanol did not significantlyaffectthe endurance of males during the swimming test, and led to a decrease in endurance of females. Biochemical studies showed that prolonged administration of ethanol to male and female rats leads to the accumulation of toxic products (urease, ammonia, lipid peroxidation products), stimulates the intensificationof inflammation(increased activity of acid phosphatase) against the suppression of nonspecificresistance (decrease of catalase and lysozyme activity) in the brain of rats under chronic alcohol intoxication.
Conclusions. Alcohol consumption did not significantlyaffet the endurance of males, but reduced the endurance of females. The survey of the brain of rats showed the accumulation of toxic products, the intensificationof inflammationagainst the background of the suppression of nonspecificresistance under the influenceof ethanol.
PHARMACOCHEMICAL ANALYSIS AND MEDICAL USE OF PLANTS OF THE GENUS DAUCUS (Review)
Authors: Prystupa B. V. , Bogatu S. I. , Rozhkovsky Ya. V.
Published: December 2022

It is known that modern possibilities of pharmacotherapy of various diseases have significantly increased. The search for and creation of effective and safe drugs with a wide range of pharmacological activity remains relevant.
Plants of the genus Daucus are a promising plant for a detailed pharmacognostic research. Representatives of the genus have been used for centuries in folk medicine of different countries and exhibit a wide range of medicinal properties. Carrot plants have not been sufficiently studied in phytochemistry and pharmacology.
The aim of the study was to analyze the scientific literature and databases of PubMed, Google Scholar on the botanical characteristics, phytochemical composition and medicinal uses of plants of the genus Daucus.
The presence of coumarins, phenols, flavonoids, alkaloids, essential oils, carotenoids, ascorbic acid, riboflavin, niacin, thiamine, tocopherol and lutein has been proven in extracts from plant raw materials of different varieties of carrots. The content of biologically active substances can be determined by such factors as variety, temperature, air quality and carbon dioxide content in it, processing and storage.
Plants of the genus Carrot (Daucus) are rich in biologically active substances, are actively used in both folk and official medicine, exhibit a wide range of pharmacological properties, including antioxidant, cytotoxic, antitumor, anti-inflammatory, analgesic, antifungal, antibacterial, antiphteric, hepatoprotective, antihypertensive, carminative, diuretic, antispasmodic, wound-healing and immunostimulatory effects.
Analysis of the world experience in the use of plants of the genus Daucus in folk medicine, experimental research on the phytochemical composition of plants of the said genus and a wide range of their pharmacological activity showed that aboveground and underground organs of different species of plants of the genus Daucus can be considered promising raw materials for further research on their basis of new phytopreparations of a wide range of action.
SPIDERS (ARACHNIDA, ARANEI) OF THE TYLIGUL ESTUARY OF ODESA REGION (UKRAINE)
Authors: Deli O. F. , Pidhorna S.Ya. , Chernychko K. Y.
Published: December 2022

Topicality. The article provides information about the species composition of spiders in the Tyligul estuary of Odesa region.
Aim. Study of araneofauna of various biocenoses of the Tyligul estuary, Odesa region.
Methods. Standard methods of collecting spiders were applied. We used Barber soil traps, hand collection, mowing with an entomological net.
Results. During the research period between 2016 and 2020, 57 species of spiders from 22 families were discovered, among them 42 species were noted for the Tyligul estuary for the first time. For the first time, three species of spiders were noted for Odesa region: Zelotes eugenei Kovblyuk, 2009, Zelotes longipes (L. Koch, 1866) and Clubiona pseudoneglecta Wunderlich, 1994. The dominant species of the Tyligul estuary include the following species of spiders: Argiope bruennichi, Pardosa lugubris, Misumena vatia and Runcinia grammica. Subrecedents of the studied region include: Atypus muralis, Agroeca brunnea and Eresus kollari.
STRUCTURE OF MACROZOOBENTHOS COMMUNITIES ON ODES’KA AND DNISTROVS’KA BANKS (NORTH-WESTERN PART OF THE BLACK SEA)
Authors: Bondarenko О. S. , Zamorov V. V.
Published: December 2022

Introduction. Underwater banks influence the distribution of fish due to the presence of certain habitats and feed resources, a significant part of which is produced in macrozoobenthos biocenoses formed in different biotopes. There exist very little data on the state and structure of the macrozoobenthos of Odes’ka and Dnistrovs’ka banks in the modern period.
Aim. The purpose of the work was to determine the structure of macrozoobenthos groupings on different types of substrate of Odes’ka and Dnistrovs’ka banks in modern conditions.
Methods. The material was collected in the districts of Odes’ka and Dnistrovs’ka banks with a 10×10 cm area quantitative accounting frame using light diving equipment. In the laboratory, the samples were processed in accordance with the generally accepted methodology. Mathematical data processing was carried out with the introduction of multivariate statistics methods.
Results. On different types of the substrate of Odes’ka and Dnistrovs’ka banks, six communities of macrozoobenthos which significantly differed in structure were identified. The macrozoobenthos of Odes’ka Bank is characterized by high abundance, biomass and biodiversity indices compared to the macrozoobenthos of Dnistrovs’ka Bank. In the community of Mytilus galloprovincialis on Odes’ka Bank, species that were present in it before the period of intensive development of hypoxia were registered. In this community, the abundance of Mytilaster lineatus, Prionospio cirrifera increased, Alitta succinea was not found. The community of Chamelea gallina in Odes’ka Bank is characterized by high biomass and high abundance of Donax trunculus.
Conclusion. The structure of macrozoobenthos communities in the area of the Odes’ka and Dnistrovs’ka banks is significantly different. Their state reflects the trend of structural changes in macrozoobenthos in the northwestern part of the Black Sea in the modern period.
BIOINFORMATIC ANALYSIS OF GENES OF ADHESIVE PROTEIN FOOT OF MUSSELS OF THE GENUS MYTILUS
Authors: Chubyk I. Yu. , Chebotar S. V.
Published: December 2022

Introduction. Today, it is relevant to identify and study the genes of adhesive proteins that contribute to the adhesion of marine mussels under water and play an important role in the industry for the commercialization of waterproof adhesives. The purpose of our research is based on bioinformatic analysis, because modeling is currently one of the advanced methods.
Aim. The purpose of this work was to compare the nucleotide sequences of representatives of the genus Mytilus, which are flanked by primers Me 15 / Me 16, designed for the non-repetitive region of the mussel adhesive protein gene, as well as bioinformatic analysis of the complete amino acid sequence of the foot adhesive protein Mefp-1 coded by Fp1 gene for M. galloprovincialis.
Methods. Nucleotide sequences were analyzed using BLAST (NCBI [https://www.ncbi.nlm.nih.gov]) and aligned by MAFFT [Madeira et al., 2019] methods. The phylogenetic tree was built in the MEGA program [Kumar et al., 2018] using the UPGMA method [Sneath, Sokal, 1973]. The physicochemical parameters of the adhesive protein for the amino acid sequence of M. galloprovincialis were calculated using the ProtParam software tool (ExPASy [https://web.expasy.org/protparam/]). Models of the three-dimensional structure of the M. galloprovincialis adhesive protein were built on the I-TASSER online platform [Yang, Zhang, 2015; Zhang et al., 2017] and with application of the AlphaFold program [https://alphafold.ebi.ac.uk/entry/Q27409].
The main results. The analysis of the nucleotide sequences of six representatives of the genus Mytilus within the «variable region» flanked by primers Me 15 / Me 16 showed the presence of deletions and a number of SNPs. The constructed dendrogram reflected the phylogenetic relationships of mussel species in the genus Mytilus, when comparing the nucleotide sequences of the genes of the adhesive protein of the mussel foot. An analysis of the primary and secondary structure of the adhesive protein of the mussel species M. galloprovincialis characteristic of the Black Sea region was carried out, and models of the three-dimensional structure of the adhesive protein for the specified species were built.
Conclusions. The detected mutations in the studied «variable region» of the nucleotide sequences of the adhesive protein genes allow the molecular marker Me 15-16 to distinguish between four types of mussels: M. galloprovincialis, M. chilensis, M. edulis, M. trossulus. The obtained distribution of representatives of the genus Mytilus by means of cluster analysis is consistent with the literature data on the territorial distribution of these species. The molecular weight was calculated and models of the spatial structure of the gene of the foot adhesive protein of the mussel species M. galloprovincialis were constructed.
THE INFLUENCE OF ALIEN GENES OF RESISTANCE TO COMMON DISEASES ON AGRONOMIC CHARACTERISTICS OF BREAD WINTER WHEAT IN THE DRY CONDITIONS OF SOUTHERN UKRAINE
Authors: Motsnyi I. I. , Nargan T. P. , Nakonechnyi M. Yu. , Lyfenko S. Ph. , Моlоdchenкоvа О. О. , Shcherbyna Z. V.
Published: December 2022

Abstract
Introduction. A combination of fungal diseases and drought can cause significant yield losses of winter wheat (Triticum aestivum L.). It is known that alien traits introduced through wide hybridisation into wheat genome contribute to breeding of cultivars with a higher yield potential in arid environments.
Aim. The impact of alien genes of resistance to widespread diseases and morphological characters on the main agronomic traits in the arid environments of the Southern Steppe of Ukraine was analysed.
Methods. The lines were grown in a control nursery designed in 5 and 10 m2 plots on the black earth area in the 2019–2021 vegetative periods consecutively under the arid system without irrigation. The plant material included 153 experimental wheat lines of different origin with six check cultivars for the arid climate zone of Ukraine. The data on eight agronomic (quantitative scores) and six plant pathological (point scores) traits were collected and subjected to statistical analysis to comprehend the contribution of the diversity and connections between the characters.
Results. Due to the successful introgression of alien genes from all sources involved in hybridisation, the majority of lines were resistant to one of the rust species. The lines derived from the sample containing the translocation 1BL.1RS in the karyotype and Triticum timopheevii Zhuk. in the pedigree were resistant to all rust species. The lines containing the alien genes Lr42 and Hs showed a higher yield than the recurrent cultivar and standard ones. There was a negative correlation between the protein content and grain yield in 2020 (r = −0.40***). A weak positive correlation was found between the yield and resistance to yellow rust (Rsp = 0.19* in 2019 and Rsp = 0.26*** in 2020) or tolerance to Septoria leaf blotch (Rsp = 0.14 in 2019 and Rsp = 0.27*** in 2020). Under drought conditions, the yield reduced by 32.5% in 2020 and by 70% in 2021. The drought resistance index directly correlated with the yield in the dry conditions of 2020 (r = 0.69***), and also was inversely proportional to the yield values (r = −0.26**) obtained in favorable conditions.
Conclusions. The studied experimental lines have a potential for use in the wheat improvement programs for resistance to the diseases in Southern Ukraine. For further breeding, eighteen lines with a high weight of 1000 kernels, protein content, and yield, and resistance to drought or disease were identified, and four promising drought-tolerant lines have been selected.
PRIORITY DIRECTIONS OF SCIENTIFIC RESEARCH H. V. FLOROVSKY IN THE «ODESA» PERIOD OF LIFE: PHILOSOPHY, PSYCHOLOGY, BIBLIOGRAPHY, PHYSIOLOGY
Authors: Levchenko V. V.
Published: December 2022

The article attempts to consider the nature of the formation of priority areas of scientific activity and spiritual formation in the «Odesa» period of the life of the religious thinker, theologian, philosopher, historian, Orthodox priest, activist of the ecumenical movement and one of the founders of the World Council of Churches. His name is H. V. Florovsky. On the basis of previously not introduced into scientific circulation historical sources located in the State Archive of the Odesa Region, Princeton University Library and a layer of published sources and scientific literature, many new facts of the biography were discovered and inaccuracies and incorrect data regarding the main events of the scientist’s life were eliminated. Both general scientific (analysis and synthesis, induction and deduction) and special historical methods became the main methods of researching the life and intellectual work of H. V. Florovsky. The historical-genetic method made it possible to recreate the creative portrait of the scientist within the chronological framework of the period under study. The historical-comparative method was used to highlight what was new, which the scientist brought to the study of humanitarian fields of knowledge. Chronological, historical-biographical methods, techniques of historiographical and source analysis were also used. The essence and role of the main components of the scientist’s personality, which later determined the success of his professional activity, were revealed. It has been proven that the family played a significant role in the formation of H. V. Florovsky’s personality. The main milestones of life and spiritual formation are presented through the prism of his studies, work and scientific activity at the Imperial Novorossiysk University. The importance of the obtained results lies in the fact that, on the basis of archival material and scientific literature, the formation of scientific priorities and scientific and pedagogical experience of a scientist, a component of ensuring the relationship of traditions and innovations in the development of humanitarian knowledge, are analyzed. It has been established that the defining topic in the comprehensive study of the «Odesa» period of H. V. Florovsky should be the further research of the scientist’s creativity against the background of the specific circumstances of his biography.