bluuebunny/crossref_metadata_2025 huggingface dataset:
APAKAH TATA KELOLA PEMERINTAHAN DAN STRUKTUR POLITIK MAMPU MENEKAN KECENDERUNGAN TERJADINYA KORUPSI DI INDONESIA?
Authors: Wartiningsih Wartiningsih
Published: September 2022

Corruption is still a serious problem in the state finances management in Indonesia despite of various efforts to improve the bureaucracy management and government financial reports. The implementation of a decentralized system and direct elections in the legislative and executive government institutions based on divided government political structure, are expected to boost the check and balances process and the creation of high quality financial reporting system. However, this system does not reduce the propensity of corruption occurrence. Therefore, this study aims to examine the role of the financial reporting system as the embodiment of governance and the role of divided government to the corruption. The corruption data used in this study is inkracht data so that it can describe the actual corruption cases compared to the corruption variable in the form of perception that is more subjective and tends to be biased. The results of the study show that governance with the BPK opinion indicator obtained by the district / city government is not substantively describing the use of state finances. In the other word, corruption still occurs in the local government that have obtained the best opinion. Meanwhile, the divided government which theoretically should encourage checks and balances, it creates a negotiation space that promote bigger chance of corruption come about. Apart from the study result, efforts to eradicate corruption in the first period of President Jokowi's reign were better than the previous regime.
Analysis of Non Performing Loans in Indonesian Banking (Case Study on MSMES 2017Q1 – 2019Q4)
Authors: Putri Audrya Luthfi , Sugiyanto Fransiscus Xaverius
Published: September 2022

Lending is the main activity of banks in generating profits, but the biggest risks are also derived from lending. According to the financial services authority of Indonesia statistics, based on the type of use, the most credit distribution is micro small and medium enterprises (MSMEs). It can be concluded that credit is the main target of lending by banks. This research was conducted to analyze how internal bank factors can affect bad MSMEs credit Indonesian banks in the first quarter of 2017 to the fourth quarter of 2019 with a CAMEL analysis approach. Independent variables used are Capital, Assets, Management, Earning, and Liquidity, each of which is proxied using CAR, KAP, NIM, ROA, and LDR ratios. The dependent variable used is bad credit, which is proxied by the NPL ratio. The data panel method is used to quantitatively estimate the parameters in the model. The results showed that banking capital fluctuated during 12 quarters, namely from 2017 to 2019. In terms of liquidity, it is known that some banks have liquidity ratios above the tolerance limit set by Bank Indonesia. It is necessary to have control of bank management to inhibit the aggressiveness of lending, as well as to raise deposit rates for banking funding to increase.
Multiplier and Velocity of Money Relationship of Cartal and Electronic in Indonesia 2009.Q1-2018.Q4
Authors: Barus Elitna Br , Sugiyanto Fransiscus Xaverius
Published: September 2022

This research explain about the impact of electronic money and currency on money multiplier M1 and velocity of money M1 with VECM analyzing method. data used in this reserach are secondary data, it used from 2009 quarter I until 2018 quarter IV. There are 4 measurements that are used to measure money multiplier, electronic money, currency ratio, excess reserve ratio, reserve requirement ratio. To measure velocity of money there are 5 measurements that are used, electronic money, currency, inflation, product domestic product, and interest rate SBI. The result found that in the long term electronic money and currency affected money multiplier M1. On the velocity of money model electronic money and currency affected velocity of money M1 on the long term. The result of impulse response function (IRF) on money multiplier M1 show that electronic money has a positive correlation, while the currency ratio has a negative correlation, on the velocity of money model both electronic money and velocity of money showed a negative correlation. In variance decomposition found that electronic money has a huge contribution to affect money multiplier model and velocity of money model M1. Thus the results of the study can be concluded that electronic money affected both money multiplier M1 and velocity of money M1. The monetary authorities should take electronic money into consideration as crucial variable in the money supply to maintain the stability of money supply.
Determination of Poverty At The District/City Level in Yogyakarta Province 2007-2018
Authors: Septianingrum Resiska , Iskandar Deden Dinar
Published: September 2022

Poverty is a thing that occurs in all countries both developing countries and developed countries, and one of them is in Indonesia. Special Region of Yogyakarta is ranked first as the region with the highest poverty rate in Java. This study aims to analyze the effect of regional gross domestic product, population, health and unemployment rate on poverty in Special Region of Yogyakarta. The analytical method used is panel data regression with the Fixed Effect Model (FEM) approach. The data usage is time series data for 12 years (2007-2018) and cross section data of 5 districts / cities in the Province of Special Region of Yogyakarta. The results of this study indicate that the population and health variables have a positive and significant effect on the number of poor people in the Province of D.I. Yogyakarta. GRDP variable has a negative and significant effect on the number of poor population in the Province of D.I. Yogyakarta, while the unemployment rate variable has a negative and not significant effect on the number of poor people in the Province of D.I. Yogyakarta.
INFLUENCE OF SOCIAL ENVIRONMENT AND LIFESTYLE FOR COMMUNITY CONSUMPTION BEHAVIOR IN THE PANDEMIC COVID 19
Authors: Wiyono Eko Hadi
Published: September 2022

The purpose of this study was to determine: (1) the influence of the social environment on people's consumption behavior on the covid pandemic 19. (2) The influence of lifestyle on people's consumption behavior on the covid pandemic 19. (3) the influence of the social environment and lifestyle on behavior public consumption in this pandemic occurs. The research method used in this study is a descriptive method with a quantitative approach. The population in this study is the Palmerah village community. The sample used was 128 people. The analysis technique used is multiple linear regression analysis. Based on the results of the study concluded that: public consumption during the covid pandemic 19. The coefficient of determination (adjusted R2) of 0.095, meaning that 9.5% of people's consumption behavior is influenced by the social environment and lifestyle, while the remaining 90.5% is influenced by other factors.
ANALISIS PENGARUH BRAND IMAGE, SERVICE QUALITY, KEPUASAN PELANGGANDANLOYALITAS KONSUMEN RUMAH SAKIT
Authors: Pudjonarko Cahyamas Arif Satria , Indriani Farida
Published: September 2022

The research objective is to analyze the influence ofbrand image, service quality, customer satisfaction on loyalty to return to the hospital in Permata Medika, Semarang through service quality and customer satisfaction as interveing variable.The sampling method used in this research is non-probability sampling with a purposive sampling technique. The samples collected were 100 respondents at Permata Medika Hospital to find out information about re-visit intention in the hospital. The analytical method used is multiple analysis techniques which include validity test, reliability test, classic assumption test, multiple linear regression test, t test, f test, determination test, and sobel test.The results showed that brand image had a positive and significant effect on service quality and loyalty but negative and not significant on customer satisfaction, service quality had a positive and significant effect on customer satisfaction and loyalty, and customer satisfaction had a positive and significant effect on customer loyalty.
Hepatoprotective potency of Lagenandra toxicaria and Ariopsis peltata against CCl4 induced liver fibrosis in Wistar rats
Authors: Akarsha B , Krishnakumar G , Khandige Prasanna Shama
Published: September 2022

Lagenandra toxicaria (LT) and Ariopsis peltata (AP) belongs to the family Araceae. LT is being traditionally used to cure bilious symptoms and wound healing. AP leaves are edible and the rhizome has medicinal value. With such a wide range of medicinal applications, it's essential to scientifically authenticate traditional usage and find the plant's bioactive components. Here, we have examined the anti-inflammatory and hepatoprotective potency of these plant extracts. The in-vivo liver fibrosis was induced in Wistar male rats using CCl4 and was treated with various concentrations of the methanol and water extracts of the plant rhizomes. In the in-vitro anti-inflammatory assay, LT methanol extract showed 42 % protection at 600 mg/ml which is higher than the other extracts. Among the AP and LT extracts, the 600 mg/kg methanol extract of LT treated rats showed a decreased (p<0.05) serum alanine/aspartate aminotransferase and total bilirubin levels. The plant extract brought about an amelioration of CCl4 induced pathological effects and a significant reduction in the severity of inflammation, fatty metamorphosis, necrosis and liver fibrosis. Overall, the results suggest that LT rhizome could be effective in the treatment of liver fibrosis. It is possible that this is related to the presence of anti-inflammatory and antioxidant chemicals such as 9-octadecenamide, flavonoids and phenols in the extract.
Economic Analysis of Feeding Locally Formulated and Commercial Milk Replacer to Camel Calves in the Arid and Semi-Arid Lands of Kenya
Authors: Tura Isako , Ondiek James , King’ori Anthony , Onjoro Paul
Published: September 2022

Despite the huge potential for the growth of camel herds, calf mortality remains a challenge among the pastoral camel keepers in Kenya. This is due to competition for milk by calves and households for domestic consumption and trade among other factors. Adoption of Commercial Milk Replacer (CMR) and locally formulated Plant Based Milk Replacer (PBMR) as an alternative to camel milk feeding has the potential of improving the camel calves’ nutrition and household income. Ten camel calves were randomly assigned to two separate diets; PBMR and CMR, five in each diet, for 70 days. A control group of 5 calves on the pastoral milk feeding regime was also observed. Calves on PBMR were confined throughout the experimental period while calves on CMR were not confined but fed 2 litres of CMR daily. All the calves were weighed weekly. This study employed a Cost Benefit Analysis (CBA) to assess the financial viability of using PBMR and CMR as a replacement to camel milk. Costs which included milk replacer and labour were captured and extrapolated for ten years to show the benefits of PBMR over CMR. Net Present Values (NPV), a financial analytical tool that shows viability of each feeding regime was then calculated. The results showed that it is more economical to feed calves using PBMR (5) compared to CMR (3) or pastoral feeding regime (3). The study recommends promotion of PBMR among pastoral camel keepers for improvement of nutritional status of suckling camel calves and household income.
The General View of Psychotherapy / The Meta Model and Predictive / Preventative Mental Health Care Have Seven Groups of Reasons That Affect the Four Cornerstones of Well-Being
Authors: Heiska Juhani
Published: September 2022

A common goal among the many schools of psychotherapy these days is to find elements of psychotherapy that apply to many of them. The basis for which a general view like this can be found consists at least of the language and terms used, discovery of new activities, the structure of therapy and the work environment. Since the realization of psychotherapy also attempts to prevent a patient's situation from worsening, the following question comes up: does the search for a psychotherapy metamodel feature elements that are similar to predictive mental health care? Mental health care in Finland employs a categorization of seven reasons and four cornerstones of well-being to prevent mental malaise, mental disorders, and negative exceptional behavior. This study collected a file of psychotherapeutic research results and compared it against a file regarding predictive mental health care, which affirmed the thesis “the general view of psychotherapy and preventative mental health care have a functional common categorization that consists of seven groups of reasons and four cornerstones”.
The Effect of Accounting Understanding and Tax Provisions on Calculating, Depositing, and Reporting of Tax at Pt. Xyz - A Case Study on a Startup
Authors: Panduwinata Vina , Sidharta Juaniva , Simanjuntak Ramot
Published: September 2022

Technological developments gave a lot of influence on human life in general, from daily activities until there are several digital-based business models, known as startups. As of 2018, according to MIKTI  (Indonesian: Masyarakat Industri Kreatif Teknologi Informasi, or Information Technology Creative Industry Society) database, there were 992 startups in Indonesia. Startup company tax is an obligation that must be paid on income received or transactions related to withholding PPh (Indonesian: Pajak Penghasilan, or Income Tax) made by startup companies and requires special tax treatment in order to develop their business. The factor of understanding tax accounting provides a significant contribution to the compliance of corporate taxpayers in fulfilling income tax obligations. The research in this journal aims to gain knowledge of the extent of understanding of accounting and tax provisions in depositing and reporting taxation at one of the startups in Greater Jakarta.
Perceptions of "Incurable" Diseases and Therapeutic Responses among Traditional Healers in the District of Abidjan
Authors: Francis Adiko Adiko , Gérard N'Goran Kouakou , Adrien Koua Kouakou
Published: September 2022

In Africa and particularly in Côte d'Ivoire, traditional medicine highlights the consideration of the association between biological, psychological and social factors within the framework of public health policies. But in reality, it is clear that there is a neglect of the psychosocial dimension in favor of the biomedical aspects, even on the part of traditional healers in the management of incurable diseases. Indeed, traditional medicine seems to be part of a process of reduction to phytotherapy drugs while ignoring its cultural basis. The question is to know which posture and which approach appear to be the most appropriate in the evaluation, prevention and treatment of complex diseases. The objective of this research is to describe and analyze the perceptions of the causes of so-called "incurable" diseases and the therapeutic responses proposed by traditional healers. The methodology was based on documentary research and semi-structured interviews with 30 traditional healers in the district of Abidjan. The results show that the perception of causes and therapeutic responses are surrounded by complexity. This research has therefore highlighted the fact that people with an incurable disease are considered by traditional healers as people in need of psychosocial care. Ultimately, it should be noted that traditional medicine offers an alternative response to the management of so-called incurable diseases in the district of Abidjan. These characteristics of the perception of causes and therapeutic responses are parameters to be considered in the management of so-called incurable diseases in African society.
The Rationale Behind the Influence of English on Modern Colloquial Sinhala Language
Authors: Gamage Upul Priyantha , Dilani Nipunika
Published: September 2022

The causes of language influence that come under contact linguistics is a topic of common interest among linguistic academics nowadays. Sinhala is the majority language in Sri Lanka that has evolved over 2000 years and during this long retro, it has had both oriental and occidental language influences while the major impact has received from western languages after colonising the country. This piece of research employed two primary data collection methods: participatory observation and chunk recordings while collecting secondary data from the previous literature. As the sampling strategy, we used convenient sampling and the analytical technique of data was content analysis. The main objective of conducting this research was to find out the exact causes of the English language influence on modern colloquial Sinhala over the last 200 years. The study has established the main causes of English language influence on modern colloquial Sinhala as linguistic and cultural hegemony, colonisation, American expansion, superiority of social class, globalisation, commercial, industrial and religious factors while language contact is recognised as an umbrella term for these root causes. In conclusion, there have been two broad directions of these causes of English language influence that had taken place. At the beginning of the colonial rule, it had become top-bottom and now it has transferred to bottom-up, and the influence of English in the modern period on Sinhala has become complementary and multidimensional while the political influence behind the process in its nature is soft and arbitrary.
Religion and the Prevention of Hate Speech: Increasing Inclusivity through the Concept of the Malaysian Family
Authors: Nordin Munif Zarirruddin Fikri
Published: September 2022

Religion plays an important role in the prevention of hate speech through the spiritual aspect as well as the morality aspect, particularly in differentiating between good and bad, and right and wrong. In Malaysia, the latest concept, that of ‘the Malaysian Family’ (Keluarga Malaysia), which was introduced in October 2021, embraces three characteristics, namely inclusivity, common ground, and contentment. The enrichment of values under these characteristics mainly focuses on strengthening the big family of Malaysia, including the prevention of hate speech. However, what are the religious values in the concept of the Malaysian Family and how to increase inclusivity through the concept to prevent hate speech need to be studied. This study aims to (1) identify the religious values in the concept of the Malaysian Family, that pertain to the prevention of hate speech, and (2) explain the strategy for increasing inclusivity through the concept to prevent hate speech. The data of the study comprise the religious values, related to courtesy and morality, taken from the Quran, as well as the seven enriching values that fall under the characteristic of inclusivity in the concept. The findings show that there are a number of religious values related to courtesy and morality in the concept, which pertain to the prevention of hate speech. The findings also show that the seven enriching values under the characteristic of inclusivity in the concept, need effective strategies for preventing hate speech, such as enhancing the role of religious leaders and the media.
An Exploration of the Personal Non-Work Factors Affecting Employee Engagement When Working from Home
Authors: Krishnamoorthy Raghu
Published: September 2022

This paper reports on the research investigating the personal, non-work factors that influence the employee engagement of those working remotely from home. As corporations moved their workers to work from home because of the COVID-19 pandemic, the dynamics of work and the workplace evolved, with new, non-work-related human variables acquiring significance. Emerging research indicates that working from home is here to stay, making it necessary to understand and factor in those non-work elements in employee-related decision making. This exploratory qualitative study examines the crucial non-work elements influencing employee engagement based on the lived experiences of twenty-three employees who began working from home during the pandemic. Findings reveal that concerns about health, well-being, and work-life balance influence employee engagement when people work from home. The paper suggests that decision-makers look at the results of this study when answering important questions about the future of work and how things that do not have anything to do with work could affect how engaged employees are when they work from home.
Clinical evaluation of the OC-Sensor Pledia calprotectin assay
Authors: Butenas Juozas , Ayling Ruth M.
Published: September 2022

Objectives

Faecal calprotectin (f-Cal) and faecal haemoglobin (f-Hb) are important tests for evaluation of gastrointestinal disease. Samples for measurement of f-Hb are taken by the patient directly into a specimen collection device containing stabilising buffer, which can be placed directly onto the analyser in the laboratory. Samples for f-Cal are usually sent in screw top pots and often require time-consuming extraction procedures prior to analysis. OC-FCa calprotectin is a new assay which uses the same specimen collection device and analyser as our current f-Hb assay. Analytical evaluation has already shown it to perform well but to have a positive bias. This study was a clinical evaluation to investigate the diagnostic test performance and cut-off suitable for its use in the diagnosis of IBD.

Methods

OC-FCa calprotectin was measured in a convenience sample of 603 patients in whom f-Hb had been requested and was found to be ≥10 μg/g. Clinical outcomes were obtained from notes, radiological reports and endoscopy and histology reports.

Results

A total of 425 patients completed clinical investigations; IBD was diagnosed in 49 and other colorectal pathology in 161. Median f-Cal in patients with IBD was 1,660 μg/g, significantly different (p<0.01) from those with other colorectal pathology (192 μg/g) or normal findings (157 μg/g). ROC curve analysis showed AUC of 0.898 with sensitivity of 91.8% and specificity of 79.3% at a cut-off of 600 μg/g.

Conclusions

The new OC-FCa calprotectin assay performed well for the diagnosis of IBD using a cut-off of 600 μg/g.
A case of placental multiple giant chorangioma leading to neonatal death from fetal hydrops
Authors: Shiraga Aoi , Ohsuga Takuma , Kawasaki Kaoru , Mogami Haruta , Minamiguchi Sachiko , Mandai Masaki
Published: September 2022

Objectives

Although placental chorangiomas are often asymptomatic, larger tumors (>4–5 cm) can cause various perinatal complications, including polyhydramnios, preterm birth, fetal anemia, fetal hydrops, and intrauterine fetal death. Symptomatic placental chorangiomas are often diagnosed prenatally on ultrasonography as a mass on the fetal side of the placenta.

Case presentation

A 37-year-old pregnant woman underwent emergency cesarean delivery at 34 weeks’ gestation due to rapidly progressive fetal hydrops leading to fetal dysfunction, resulting in neonatal death. Placental pathology indicated multiple placental giant chorangiomas that occupied 40% of the placenta. Because of the disk shape of the placenta, prenatal diagnosis by ultrasonography was difficult.

Conclusions

Some placental chorangiomas are difficult to diagnose and lead to fetal hydrops and poor prognosis, even if ultrasonography does not show an obvious mass in the placenta.
Teaching the science of uncertainty
Authors: Moulder Glenn , Harris Emily , Santhosh Lekshmi
Published: September 2022

As we increasingly acknowledge the ubiquitous nature of uncertainty in clinical practice (Meyer AN, Giardina TD, Khawaja L, Singh H. Patient and clinician experiences of uncertainty in the diagnostic process: current understanding and future directions. Patient Educ Counsel 2021;104:2606–15; Han PK, Klein WM, Arora NK. Varieties of uncertainty in health care: a conceptual taxonomy. Med Decis Making 2011;31:828–38) and strive to better define this entity (Lee C, Hall K, Anakin M, Pinnock R. Towards a new understanding of uncertainty in medical education. J Eval Clin Pract 2020; Bhise V, Rajan SS, Sittig DF, Morgan RO, Chaudhary P, Singh H. Defining and measuring diagnostic uncertainty in medicine: a systematic review. J Gen Intern Med 2018;33:103–15), as educators we should also design, implement, and evaluate curricula addressing clinical uncertainty. Although frequently encountered, uncertainty is often implicitly referred to rather than explicitly discussed (Gärtner J, Berberat PO, Kadmon M, Harendza S. Implicit expression of uncertainty - suggestion of an empirically derived framework. BMC Med Educ 2020;20:83). Increasing explicit discussion of – and comfort with -uncertainty has the potential to improve diagnostic reasoning and accuracy and improve patient care (Dunlop M, Schwartzstein RM. Reducing diagnostic error in the intensive care unit. Engaging. Uncertainty when teaching clinical reasoning. Scholar;1:364–71). Discussion of both diagnostic and prognostic uncertainty with patients is central to shared decision-making in many contexts as well, (Simpkin AL, Armstrong KA. Communicating uncertainty: a narrative review and framework for future research. J Gen Intern Med 2019;34:2586–91) from the outpatient setting to the inpatient setting, and from undergraduate medical education (UME) trainees to graduate medical education (GME) trainees. In this article, we will explore the current status of how the science of uncertainty is taught from the UME curriculum to the GME curriculum, and describe strategies how uncertainty can be explicitly discussed for all levels of trainees.
Nonconvergence toward the standard: the maintenance of a distinctive use of rhotics among the Santomean diaspora in Portugal
Authors: Bouchard Marie-Eve , Desmeules-Trudel Félix
Published: September 2022

The variable use of rhotics is a salient linguistic feature in the variety of Portuguese spoken on São Tomé Island. In this study, we employ ethnographic and variationist sociolinguistic methods to report on the use of rhotics by 40 Santomeans living in Portugal. The objective is to determine whether Santomeans who are in closer proximity with European Portuguese, which is the variety perceived as standard and more prestigious in Portugal, tend to use rhotics in a more standard way or if they maintain the distinctive use of rhotics from their island. The results indicate that Santomeans do not converge toward a more European standard use of rhotics. We argue that the distinctive use of rhotics is available for identity-driven use to express a connection to São Tomé and Príncipe.
Target location service system in microgrid operation based on internet of things
Authors: Zhang Jiajie
Published: September 2022

With the gradual reduction of conventional energy sources, the problem of environmental pollution is becoming more and more serious. Environmentally friendly, efficient and flexible power generation models are widely favored, and microgrids emerge as the times require. Microgrid is a medium and low voltage network including power distribution, storage devices, loads and other equipment. It can operate in grid-connected mode or as a stand-alone system in an island environment, continuing to supply power to users even when the large grid is disrupted. Compared with traditional power grids, microgrids have small capacity and changeable operation modes, making it difficult to locate distribution areas and short-circuit currents. At the same time, it is difficult to trace the faults during operation. So far, microgrids have had a lot of technical issues in operation that need to be resolved quickly. In recent years, IoT technology has developed rapidly. The Internet of Things is a comprehensive network that integrates location services, monitoring services, information identification and monitoring services through information exchange and communication technologies, such as video recognition technology, positioning technology, and wireless sensor technology. In order to monitor the operation mode of the microgrid in real time, find the source of the fault and locate the operation target, based on the Internet of Things technology, this paper installs wireless sensors in the line segment to monitor the line and other applications. This paper uses wireless sensor networks to record positioning variables, processes and data analysis to achieve the accuracy of microgrid operation target positioning. In addition, in order to improve the positioning accuracy of wireless sensor monitoring network and solve the problem of energy limitation, DV-Hop algorithm EB-IDMF algorithm and R-A algorithm are also introduced. Finally, the feasibility of the system is verified through experiments and tests. With the blessing of the positioning algorithm, the positioning accuracy is improved by 4.9%, which has great practical value for the target positioning of microgrid operation.
User-side precision marketing model of integrated energy service system
Authors: Yao Wei , Han Wei , Zheng Yong , Gao Songyao , Li Ran
Published: September 2022

Since entering the new era, the utilization and protection of energy has gradually become a world-class problem, and the establishment of a comprehensive energy service system is one of the effective solutions to today’s energy problems. The establishment of the comprehensive energy service system successfully integrates the fragmented and single energy structure and realizes the multi-energy complementarity between energy sources. However, the current comprehensive energy service is still limited to the integration of several common energy sources, and the system cannot realize dynamic dispatch between energy sources. User-side precision marketing can predict various energy demands. Therefore, establishing a user-side precision marketing model can strengthen the energy efficiency management of the energy system and realize the optimization and upgrading of the comprehensive energy service system. Based on this, we propose a user-side precision marketing model. It can effectively act on the comprehensive service system, and propose effective solutions for the forecast and dispatch of energy demand. At the same time, the article also aims to improve the utilization efficiency of multiple energy sources in comprehensive energy services, reduce multiple costs in energy dispatch, improve economic and environmental benefits, and promote energy conservation and emission reduction. Experiments show that the precise marketing model based on the user side can effectively increase the energy supply speed by 50.1%, reduce the supply cost by 32%, and improve the energy supply efficiency by 33%. This fully shows that the comprehensive energy supply and precision marketing model based on the user side can get rid of the previous single energy supply situation and improve energy utilization efficiency.
Halimeda gracilis (Kadarpassi chooranam) Phytochemical analysis and biological significance – a novel Siddha drug
Authors: J.V. Sabari Anandh , K. Manimekalai , A. Rajendra Kumar , S. Bragadeeswaran
Published: September 2022

Objectives

To evaluate biological activity and the phytochemical analysis of kadarpassi chooranam. Seaweeds are the marine macro algae, species belonging to Protista kingdom that has no true system, internal vascular systems, seeds and flowers. It has a lot of biological activity and has been proven to have a lot of medicinal benefits. Since time immemorial, their usage in traditional medicine has been recognized.

Methods

Halimeda gracilis has been standardized as per siddha pharmacopoeia standard protocol guidelines and prepared kadarpassi Chooranam curtained for Phytochemical analysis (qualitative and quantitative) and carried out various pharmacological activity.

Results

The antioxidant, anti-inflammatory, and anti-cancer actions of kadarpassi Chooranam have been associated to alkaloids, phenols, flavonoids, cardiac glycosides, saponins, tannins, and diterpenes.

Conclusions

The Siddha medicine, kadarpassi chooranam has various phytochemical bioactive compounds, and because of its pharmacological activity can be a potential drug candidate for human use.
Facts and doubts on the beginning of human life – scientific, legal, philosophical and religious controversies
Authors: Kurjak Asim , Stanojević Milan , Barišić Pavo , Ferhatović Amila , Gajović Srećko , Hrabar Dubravka
Published: September 2022

It is very complicated to give correct answer to the question “How to define human life?” Nowadays dilemmas consider the respect of human life from the birth to death involve not just biology but also other sciences like philosophy, theology, sociology, psychology, law and politics. These sciences evaluate the topic from different points of view. Integration of all of these perspectives could result with a proper definition. The principal purpose of this paper is to try to determine when a human individual begins. If this proves to be too difficult, we might have to settle for a specific stage in the reproductive process before which it would be impossible to say with any plausibility that a human individual exists. It is necessary to return the moral dimension of observation to the science of life. The point is to reconcile the universal ethical principles concerning the absolute value of life with the everyday challenges and dilemmas. It is our deepest conviction that life has an absolute value and that there always remains something indestructible and substantial in life, which may neither be evaluated by anything final, nor completely reduced to the material biological equivalent and the genetic substratum.
The effect of short post-apnea time on plasma triglycerides, lipoprotein and cholesterol derived oxysterols levels
Authors: Dolscheid-Pommerich Ramona C. , Stoffel-Wagner Birgit , Reinicke Madlen , Stellaard Frans , Lütjohann Dieter , Eichhorn Lars
Published: September 2022

Objectives

Apnea diving is characterized by extreme hypoxia and hypercapnia. Possible pathophysiological processes concerning the cardiovascular system are not yet fully understood. Hypoxia has effects on triglyceride metabolism and circulating blood lipids. To date, in voluntary apnea divers, no short-time hypoxia expositions focusing on plasma triglycerides, lipoprotein and cholesterol derived oxysterols levels have been performed. We hypothesize that short time hypoxemia leads to altered triglyceride, cholesterol, and oxysterol plasma levels in voluntary apnea divers.

Methods

Ten athletes performed apnea under dry conditions in a horizontal position. Plasma levels of lipids, lipoproteins and oxysterols were determined with turbidimetric immunoassays, gas chromatography (GC) - flame ionization detection (FID) and GC-MS-SIM before apnea, immediately after apnea and 0.5 h after apnea. All sterols and oxysterols were corrected for GC-FID cholesterol as measured in the same sample. Spearman’s rank correlation test was performed and pairwise comparison of absolute and cholesterol corrected plasma levels from the different sampling dates was conducted using a robust mixed linear model.

Results

We observed significantly reduced levels of apolipoprotein B, triglycerides, cholesterol, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and oxysterols (7β-OHC, 24-OHC, 27-OHC and 7-KC) for different time points. Cholesterol corrected plasma levels of the oxysterols showed no significant changes after short post-apnea time except for a significant elevation of the cholestane-3β, 5α, 6β-triol ratio.

Conclusions

We could observe that a single short time hypoxemia under dry conditions in voluntary apnea divers leads to altered triglyceride, cholesterol and oxysterol plasma levels.
Novel GLDC variants causing nonketotic hyperglycinemia in Chinese patients
Authors: Zhao Xiangyue , Zhang Guoqing , Dong Shumei , Yao Ru-En , Li Niu , Yu Tingting , Bei Fei , Wang Jian
Published: September 2022

Objectives

Glycine decarboxylase gene (GLDC) mutations cause nonketotic hyperglycinemia (NKH). Patients of NKH usually have heterogeneous phenotypes including respiratory failure, lethargy, myoclonic jerks, and hypotonia. The excessive glycine accumulation in brain is a crucial pathogenic mechanism.

Methods

We performed a clinical phenotypic analysis of two Chinese patients and conducted whole exome sequencing to detect possible pathogenic genes. Transcriptional experiments were carried out to evaluate the impact of GLDC c.862-2A>G on GLDC transcript splicing.

Results

GLDC variants were identified in both patients who mainly presented with hypotonia, apnea, and lethargy patient 1 had compound heterozygous variants, which were c.334+5G>C and c.862-2A>G, while patient 2 had c.862-2A>G and c.2098C>G (p.P700A) in GLDC. Transcriptional experiments of GLDC c.862-2A>G revealed the presence of aberrant transcripts leading to truncated protein products.

Conclusions

Both patients were diagnosed with neonatal NKH. Two novel splice-site variations in GLDC, c.334+5G>C and c.862-2A>G, were identified. The c.862-2A>G variation was found in both patients and was confirmed to affect the splicing of GLDC. Our study enriched our knowledge of the genotypic and the phenotypic spectrum of NKH.
Family language policy among Kurdish–Persian speaking families in Kermanshah, Iran
Authors: Tamleh Hadis , Rezaei Saeed , Boivin Nettie
Published: September 2022

Minority language studies have received increasing attention over the last decade in Iran. Drawing on Spolsky’s (Spolsky, Bernard. 2004. Language policy. Cambridge: Cambridge University Press) language policy theoretical framework, this inquiry reports on the language ideologies, practices, and management efforts of an under-explored group of Kurdish families residing in the city of Kermanshah. To this end, semi-structured interviews and ethnographic fieldwork guided the collection of data from 40 Kurdish–Persian bilingual parents. The thematic analysis of data revealed glaring inconsistencies among the three elements of family language policy (FLP). That is parents’ strong attachment to Kurdish did not necessarily translate into their language practices and efforts. The results also suggest that the studied parents adopted a subtractive approach to their children’s proficiency in Kurdish. We argue that parents are not the core force in heritage language maintenance and there are other external factors determining the transmission of the home language.
Preparation and radiolabeling of Iranian Androctonus crassicauda scorpion venom with technetium-99m as a new agent for cancer diagnostic and therapeutic purposes
Authors: Yekany Leila Valipour , Babapour Mofrad Farshid , Shirmardi Seyed Pezhman , Erfani Mostafa , Zare Mirakabadi Abbas
Published: September 2022

One of the innovative methods in cancer treatment with fewer side effects is the use of active principles produced by animals and microorganisms to generate new drugs with diagnosis and treatment capability for cancer. Androctonus crassicauda scorpion venom has high potential as an anti-tumor agent and has the ability to interfere with human physiology but is still unknown. Therefore, labeling venom with radionuclides is very important to study the biological distribution of toxins for diagnostic and therapeutic purposes of various diseases, especially cancer. In this research, the toxic fraction of this venom was labeled with 99mTc. The radiochemical purity of the labeled toxic fraction was obtained by using chromatographic systems. Animal biodistribution studies were performed after injecting the labeled compound into normal rats and 4T1 breast cancer-bearing mice. The radiochemical purity of 90% was obtained for labeled compound. Biological distribution studies showed relatively rapid clearance of the labeled compound from the blood circulation system. The accumulation of the labeled compound in the liver and kidney was the highest among the organs, which could indicate the possibility of toxin excretion metabolism from liver and the kidneys. The accumulation rate of the labeled compound after 15 min was 7% in the breast cancer mass, and the ratio of the distribution of the labeled compound in the breast cancer mass to the blood was 155% at 15 min post injection. The study results indicated that scorpion venom labeling with 99mTc could be a useful tool for the biodistribution and kinetic studies of the venoms for clinical use. On the other hand, based on the results of the biological distribution of the labeled compound in tumor-bearing mice, the 99mTc-venom complex can be used as an imaging agent to diagnose breast cancer. Moreover at the same time, with some measures, it can be used as a therapeutic agent for breast cancer with more consideration. We hope that the results of this study will be a step in the future for the clinical diagnostic and therapeutic purposes of cancer using natural products.
The impact of forward guidance and large-scale asset purchase programs on commodity markets
Authors: Gomis-Porqueras Pedro , Rafiq Shuddhasattwa , Yao Wenying
Published: September 2022

This paper investigates how different commodity prices are affected by unconventional monetary policies (UMP) implemented by the Federal Reserve of the United States as a response to the Global Financial Crisis. We analyze impulse responses using local projections and identify UMP shocks through high-frequency identification strategy. We show that forward guidance (FG) and large-scale asset purchase (LSAP) shocks lead to distinct responses when analyzing commodity prices. We find that asset-like commodities, such as gold and silver, respond to these UMP shocks most aggressively. While an easing FG shock leads to increases in their prices, an easing LSAP shock has the opposite effect. This differential response suggests that these asset-like commodities are being used as inflation and exchange rate hedges. In contrast, production-like and agricultural commodities respond to UMP shocks in the same way as conventional monetary policy shocks. Consistent with previous literature, we find that easing LSAP shocks, to some extent, signal a negative economic outlook. Policymakers can exploit the responses from the various commodity classes examined in this paper when evaluating the effectiveness of monetary policy in different sectors of the economy.
The importance of LDH/Albumin, LDH/Lymphocyte, and LDH/Platelet ratios in the evaluation of COVID-19 B.1.1.7 variant
Authors: Avcioglu Gamze , Otal Yavuz , Haydar Fadime Gullu
Published: September 2022

Objectives

The aim is to investigate the usefulness of lactate dehydrogenase (LDH)/Albumin, LDH/Lymphocyte and LDH/Platelet ratios on the prognosis of coronavirus disease (COVID-19) Alpha (B.1.1.7) variant pneumonia.

Methods

A total of 113 patients who were diagnosed with COVID-19 pneumonia and 60 healthy control group were included in this study. The cases were divided into 2 as classic COVID-19 group, and COVID-19 B.1.1.7 variant group. Complete blood count (CBC) and biochemical parameters of the patients were analyzed retrospectively. Patients with COVID-19 B.1.1.7 variant group were also grouped according to the length of stay in the hospital and the days of hospitalization.

Results

LDH/Albumin, LDH/Platelet, and LDH/Lymphocyte ratios were found to be higher in COVID-19 B.1.1.7 variant group when compared to the control group (p<0.001). The ferritin, neutrophils/lymphocyte (NLR) ratio, procalcitonin (PCT) and LDH/Albumin had the highest area under the curve (AUC) values in the COVID-19 B.1.1.7 variant group (0.950, 0.802, 0.759, and 0.742, respectively). Albumin, Lymphocytes and hemoglobin values were significantly higher in the COVID-19 B.1.1.7 variant group than in the classic COVID-19 group (p<0.05).

Conclusions

LDH/Albumin and LDH/Lymphocyte ratios may be useful for clinicians in predicting the risk of progression to pneumonia in COVID-19 B.1.1.7 variant patients.
Typical mechanisms of degradation of thermoelectric materials and ways to reduce their impact on the reliability of thermoelectric modules
Authors: Gorskyi Petro
Published: September 2022

The review considers a number of typical mechanisms of degradation of thermoelectric materials in the process of their functioning as a part of thermoelectric generator modules. Among them are diffusion and self-diffusion in thermoelectric materials and contact structures, loss of dopants by thermoelectric materials due to sublimation, formation of intermetallic compounds in contact structures, accumulation of structural defects under the influence of thermal and mechanical loads, mechanical destruction of thermoelectric legs, contact structures and other structural members of modules, chemical interaction of thermoelectric materials with other structural members. The main design and technological ways and methods of reducing the negative impact of these mechanisms on the reliability of thermoelectric materials and modules are also considered.
Optimizing Assignment Design for Primary and Secondary School Students
Authors: Huang Xiuwang
Published: September 2022

One of the most essential connections among all assignment tasks is assignment design. The design of high-quality assignments is critical to achieving successful homework outcomes. This study explores the existing research on the roles of assignment design and highlights the current state of assignment design in China's primary and secondary schools. In terms of assignment loads, content, formats, and stratification, suggestions are made
The Long-Term Mechanism of Extracurricular Activities in Primary and Secondary Schools: Using the Four Festivals and One Party in Huai'an No.1 Mountain Middle School as a Case Study
Authors: Sun Changshun
Published: September 2022

Extracurricular activities play a significant part in students' overall development, and the long-term mechanism is critical to extracurricular activities' educational efficiency. This paper describes Huai'an No. 1 Mountain Middle School's regular extracurricular events, which include four festivals and one party, as well as the tactics used to create a long-term mechanism for the school's extracurricular activities.
Holistic Module Learning: A Revolution in Classroom Teaching
Authors: Zhou Longjun
Published: September 2022

Since Comenius invented the classroom teaching mode centuries ago, classroom learning has experienced a succession of dramatic modifications. China’s educational progress is influenced more by traditional classroom teaching methods. Modern teaching methods place a greater emphasis on the role of students, as well as their experiences and lives. The ultimate goal of holistic module learning is to develop students’ abilities to inquire and learn on their own, which necessitates a significant shift in teaching approaches. Teachers’ primary role is to use available resources, establish optimum learning settings, and provide pupils with a variety of exploratory possibilities.
A Review of Shadow Education
Authors: Yu Jiangran , Zhang Rui
Published: September 2022

At the moment, shadow education is undergoing a rapid global expansion and has garnered widespread attention from a variety of sectors of society. After reviewing a substantial body of literature on after-school tutoring, this paper will attempt to summarize the findings of existing research on the evolution, current landscape, operating patterns, causes, impacts, and regulation of shadow education, with the goal of providing an overview of the subject for academia and sparking future research.