bluuebunny/crossref_metadata_2025 huggingface dataset:
Discourse of theoretical-methodological approaches in modern philosophy of art
Authors:   Al-Farabi Kazakh National University, Karabaeva A.G. , Ismagambetova Z.N. ,   Al-Farabi Kazakh National University, Mirzabekova A.Sh. ,   Karaganda medical university
Published: December 2023

The article analyses the priority problems of the development of contemporary art, as well as the evolution of aesthetic ideas, views in the situation of comprehensive and profound transformation of artistic relations, and interests. Changes in artistic practice, aesthetic attitudes, and philosophical assessments in the field of art are defined by the authors of the article as a problem of social contexts, multifactorial demands in the field of artistic creativity. The authors focus not only on stylistic, axiological, normative, public, contractual attitudes in the field of artistic practice and relations but primarily on latent, at the same time, prevailing artistic, aesthetic approaches, expressed in intentions, expectations, emotions, needs, forms of communication, self-realization that go beyond cognitive commensurability, aesthetic objectivity, taste comprehensibility, moral accessibility. The publication discusses some techniques and features of “theorizing” in the field of analysis of art problems in a broad sense and in the analysis of its phenomena. The authors highlight the functions of art theory, discover the “autonomy” of art theory, and point out its differences from everyday assessments, practical requests, aesthetic attitudes, and “scientific norms”.
Prognostic analysis of the religious situation in modern Kazakhstan from the perspective of the coexistence of traditional religion and religious minorities
Authors:   Karaganda University named after E.A. Buketov, Karstina S.G. , Slovakova V.E. ,   Charles University, Arinova O.T. ,   Karaganda University named after E.A. Buketov
Published: December 2023

The article presents an analysis of the historical interaction of ethnic groups on the territory of Kazakhstan, considers issues of intercultural dialogue, and identifies characteristic trends in the changing modern religious situation of the republic. The authors offer some criteria approaches to the consideration and analysis of nontraditional religions or religious minorities, distinguishing between loyal and destructive non-traditional religious associations. According to the authors, the data presented leads to the understanding of the need for more active prevention and modernization of information propaganda among the population at risk, prevention and diversion of young people from destructive ideas, including their involvement in socio-economic and political processes. Analysis of changes in the religious situation and accompanying political and social events allowed the authors to express an opinion about the reasons for contradictions in the regulation of new religious organizations, the emergence of negative attitudes in society towards non-traditional religious associations, and critical assessment of their activities. At the same time, the authors focus attention on the need to reveal and use the positive possibilities of religion, based on the deep connection between traditional cultures and religious values, and intercultural dialogue
Some aspects of the creative industry development in Kazakhstan
Authors:   L.N. Gumilyov Eurasian National University, Kasbayeva G. , Imanjussip R. ,   L.N. Gumilyov Eurasian National University, Şenay B. ,   Bursa Uludağ University
Published: December 2023

Economic, social, and political modernisation is the key to the development of the state, but cultural modernisation, in particular the modernisation of culture and the arts, is also important. This renewal (‘improvement’) of an established industry in the context of specific values (including, the West) and sociocultural realities, paradigms of progress, efficiency, improvement, development of various initiatives, emergence of subcultures, and others involves reflection in accordance with the requirements. Today, the focus on human life and culture is mainly on the values and style of the Western world and the development of individualism and greater freedom, such as creativity, which leads to an understanding and change in the modernisation of culture and art. One of the problems of high socio-cultural conditions for the development of contemporary creative industries in Kazakhstan is the lack of necessary theoretical and methodological basis for their active implementation in the domestic socio-humanitarian tradition. Secondly, systematic research of Kazakhstani society, cultural environment and science based on the work and experience of foreign scientists studying the development of this type of socio-cultural practice is needed due to the lack of publications and developments on this issue. The paper aims to review the literature on the field of creative industries in the world, analyse the achievements of individuals in the field of arts and culture in Kazakhstan and identify the legislative documents necessary for the development of the creative industries. The research is based on general historical, logical, and comparative methods. The authors believe if the state supports the creative industries in Kazakhstan, modernisation of public consciousness in Kazakhstan, conducting a policy of integration of culture and commerce within the creative industries, taking into account positive aspects of the new era, adaptable to the times; the development of the Kazakhstan “Creative Industries Development Concept” may open new horizons for the creative economy development in Kazakhstan.
The study of philosophy as a method of forming the spiritual guidelines of modern student youth in a medical university
Authors:   Karaganda Medical University, Loman N.F. , Alipbekova G.B. ,   Karaganda Medical University, Nikiforova S.A. ,   Karaganda Medical University, Lamanova A.S. ,   Karaganda Medical University, Rysbekova B.B. ,   Karaganda Medical University
Published: December 2023

This article discusses the problem of methods for the formation of spiritual orientations of modern student youth in the classes of the cycle of general education disciplines (GED), in particular philosophy. The authors single out some methods for the formation of moral guidelines for medical students since the task of covering all forms of activating the cognitive activity of students is not set. Particular attention is paid to the study of the philosophy of Abai, through active forms of learning. The study results as an analysis of feedback questionnaires indicate that students for the most part consider it important to study in the humanities and note the importance of philosophy in the profession of a doctor. Philosophy in medical school has its own characteristics. Students in the classroom comprehend their purpose and life meaning, learn to work in a team, defend their positions with arguments, thereby forming the skills of clinical thinking. As a result, it is concluded that the study of the heritage of great thinkers forms an active life position, the desire to make the world a better place promotes self-improvement, constant personal and professional growth, develops a sense of national dignity and pride in one’s people. The process of forming the spiritual and moral culture of a future healthcare specialist is important in the process of obtaining a future profession. It is rather difficult to determine the criteria for the spiritual potential of a student’s personality and to trace their development. The authors conclude that the higher the spiritual and moral culture of a future specialist in the field of healthcare, the higher his demand, social significance for society, and the study of the heritage of great thinkers can help a student in his spiritual improvement.
Axiological aspect of the communicative action in information society
Authors:   Karaganda University named after E.A. Buketov, Seifullina G.R. , Klishina M.V. ,   Karaganda University of Kazpotrebsoyuz, Tutinova N.Ye. ,   Karaganda University of Kazpotrebsoyuz, Dzhabayeva G.N. ,   Karaganda University of Kazpotrebsoyuz
Published: December 2023

In conditions of modern social changes and the transition into an open society, the issues of value-worldview attitudes and orientations of a person in the communication process have become more significant. The key problem of communication is the mechanism of communication, which translates the individual process of transmission and perception of information into a socially significant process of personal and mass impact. To analyze this issue the authors investigate the meaning of the communicative action as a separate initial act of the person’s communicative activity. This article defines the meaning of communicative action as an achievement of the common agreement and substantiates that the transition from non-verbal forms of communicative action to verbal ones expressed the process of development of abstraction in synthesis with imagination in the cognitive sphere of human consciousness. As a result, it became possible to formulate general norms leading to community integration and the development of individual identity. If the meaning of communicative action is to coordinate the interests of interacting communicants, then the meaning of the communicative space is to unite them based on already developed and agreed common values, which is of lasting importance with the self-preservation of the community and determining its future. The information society foregrounded pragmatic and axiological issues, created conditions for the necessity and possibility of understanding the multidimensionality of a person, understood as the multitude of their identities and plurality of their self-expression. In these conditions, the inseparability of the general meaning of communication in various spheres of human activity is actualized, which consists in integration of people, in pursuit of higher values - truth, goodness and beauty in this being, otherwise, the communicative action and communication as a whole will remain just technical means of communication between individuals.
Myth as a key to understanding modern legal culture
Authors:   Karaganda University named after E.A. Buketov, Tasymova A.K.
Published: December 2023

The article substantiates the role and significance of myth as the most relevant way of understanding the peculiarities of legal culture. The ahistorical semantic core of the myth is emphasized, which remains unchanged in its basic semantic parameters. Legal culture is seen as fixing some aspects of the myth at the level of everyday communication. It is proved that the axiological parameters of existence are undoubtedly determined by the myths with which modern culture is overgrown, on the one hand, resurrecting long-forgotten mythological forms, and on the other hand, producing alternative mythologems. The mythologization of law appears in the form of such trends as a return to the application of customary law, leading to degradation processes in the field of legal culture and legal consciousness. It is concluded that the presence of a scientific paradigm does not guarantee that certain myths will not function in society since from the cultural sphere itself the myth began to gradually become actualized in the field of politics and law, which can be observed in modern realities. The article substantiates the duality inherent in modern law as a developing organism, which is due to the fact that in modern conditions law begins to act as a mirror of the transformations that occur in society at the level of everyday practices. An analysis of the paradoxes of the modern legal system of national societies indicates the limitations of such a phenomenon as the mythologization of law, which in modern conditions leads to the formation of legal universals as a product of the globalization process, the logical conclusion of which will be the organization of supranational institutions that regulate the sphere of legal relations.
The essence of the concept of continuity in the formation of language
Authors:   L.N. Gumilyov Eurasian National University, Uralbaeva Sh.K. , Rakimzhanova S.K. ,   S.Seifullin kazakh agro technical research university, Dronzina T.A. ,   Sofia University
Published: December 2023

This article reveals continuity as a concept determining the relationship between language continuity and delivery between epochs, which reflects the unity of continuity and indivisibility. In the event of a break in continuity, it is assumed that the language ceases to function in the life of humanity, and through continuity in language, the way of life of the nation, its behavior, attitude to the world, culture, and experience of the life of ancestors are passed down from generation to generation. To become a “Mangilik El”, Kazakhstan needs to preserve national values and inseparable continuity between generations. Through continuity in the language, unity between the past and the future will be preserved, and innovation will also give an impetus.
Freedom as Social and Philosophical Category (Comparative Analysis of Alash Intellectuals’ Ideas and Philosophy of French Existentialists J.P. Sartre and A. Camus)
Authors:   Karaganda Technical University named after A. Saginov, Sharipova R.M. , Shormanbayeva D.G. ,   Karaganda Technical University named after A. Saginov, Ivleva Ye.N. ,   Karaganda Technical University named after A. Saginov, Khmelnitskaya О.М. ,   Karaganda Technical University named after A. Saginov
Published: December 2023

This article defines approaches to understanding freedom as a social and philosophical category through the spectacle of Kazakh intellectuals of Alash Party and existentialist philosophers from France (A. Camus, J.P. Sartre), performs the comparison and comparative analysis of understanding the phenomenon of freedom. In the history of philosophical thought, the concept of freedom underwent a long evolution; it was a subject of deep scientific sensemaking. This scientific interest has persisted up to the present day. From the research point of view, we obtain not only means helping to make possible a deeper understanding of the phenomenon of freedom, but also an opportunity to understand our modern world. The ideological inspirer, the leader of the Alash party was Alikhan Bukeykhan. This is an outstanding personality in the history of our state, due to him and other representatives of the Kazakh intellectuals; the foundation of independence was laid. Philosophical concepts of French existentialists, J.P. Sartre and A. Camus, in the context of freedom problem cause deep research interest since they not only consider the essence of human freedom but also aspects of freedom manifestations under conditions of social changes.
MUDANÇA CLIMÁTICA E O DIREITO À MORADIA: REFLEXÕES SOBRE AS SUAS IMPLACAÇÕES NA HABITAÇÃO SOCIAL
Authors: Schonardie Elenise Felzke , Stoll Sabrina Lehnen , Souza Carina Lopes de
Published: December 2023

O artigo apresenta o tema da mudança climática e do direito humano à moradia adequada em um contexto de emergência climática.  Propõe a reflexão sobre as imbricações que as mudanças climáticas produzirão no direito à moradia no país, considerando a habitação social como foco da investigação. A primeira seção ocupa-se da análise do significado da emergência climática em nível global e do reconhecimento do direito fundamental à proteção climática como condição para a proteção e concretização de direitos. Na segunda seção, aborda-se o direito à moradia enquanto direito humano de cunho social, especificamente, a habitação social no Brasil. Quanto aos aspectos metodológicos o trabalho de cunho teórico observou como método de abordagem o hipotético-dedutivo, por meio do procedimento de pesquisa bibliográfica e documental com coleta de dados indiretos e interpretação jurídica com viés sociológico. Finaliza demonstrando que o reconhecimento do direito fundamental a proteção climática está relacionada ao cumprimento das metas estabelecidas nos documentas internacionais de proteção da humanidade e que o direito à moradia no século 21 precisa ser entendido e efetivado através de políticas públicas plurais que levem em consideração aspectos ambientais decorrentes das mudanças climáticas.
الميول المهنية وعلاقتها بمفهوم الذات المهنية لدى طلبة الصف العاشر الأساسي في مديرية تربية وتعليم قصبة الطفيلة
Authors: الحراسيس سُـرى عبداللّه , الثوابيه أحمد محمود
Published: December 2023

الأهداف: هدفت هذه الدّراسة التعرف إلى الميول المهنية ومفهوم الذات المهنية، وأثر الجنس والتحصيل على كل منهما، وتكوّنت عينة الدّراسة من 350 طالبًا وطالبةً من طلبة الصف العاشر الأساسي في محافظة الطفيلة، الأردن ويشكلون ما نسبته 21% من مجتمع الدّراسة، وقد تمّ اختيارهم بالطريقة العنقودية. المنهجية: اعتمدت الدراسة أسلوب البحث الوصفي الترابطي. تكونت عينة الدراسة من 350 طالبًا وطالبة. تم اختيار العينة بطريقة عشوائية باستخدام طريقة العشوائيات المتجمعة. ولتحقيق الأهداف، تم تطوير مقياس للاهتمامات المهنية ومقياس للمفهوم المهني الذاتي، وتم التحقق من خصائصهما السيكومترية. النتائج: أظهرت نتائج الدّراسة أن مستوى الميول المهنية متوسطًا ومفهوم الذات المهنية مرتفعًا، ووجود علاقة ارتباطية إيجابية دالة إحصائيًا (ألفا 0.05) بين الميول المهنية ومفهوم الذات المهنية، ووجود فروق في درجة الميول المهنية تُعزى لمتغير الجنس ولصالح الذكور، وعدم وجود فروق ذات دلالة إحصائيًا في مفهوم الذات المهنية تعزى للجنس، ووجود فروق ذات دلالة إحصائية في الميول المهنية تُعزى للتحصيل ولصالح الطلبة الذين تحصيلهم مقبول مقارنةً بالطلبة الذين تحصلهم ممتاز ولصالح الطلبة الذين تحصيلهم جيد مقارنة بالطلبة الذين تحصيلهم ممتاز أو جيد جدًا وعدم وجود فروق ذات دلالة إحصائية في مفهوم الذات المهنية تُعزى للتحصيل.
واقع الإبداع الإداري لدى رؤساء الأقسام الأكاديمية في الجامعات الحكومية والخاصة في المحافظات الشمالية من فلسطين
Authors: عطاري مجدي حمد
Published: December 2023

الأهداف: هدفت هذه الدراسة التعرف إلى واقع الإبداع الإداري لدى رؤساء الأقسام الأكاديمية في الجامعات الحكومية والخاصة في المحافظات الشمالية من فلسطين، والفروق تبعًا لمتغيري نوع الجامعة ونوع القسم والتفاعل بينهما ولتحقيق ذلك أجريت الدراسة على عينة عشوائية طبقية قوامها (70) رئيس قسم وتمثل ما نسبته (46%) تقريبًا من مجتمع الدراسة، وطبق عليها استبانة قياس الإبداع الإداري المكونة من (25) فقرة ، وموزعة على أربعة مجالات هي: (الأصالة، الطلاقة، المرونة، الإحساس بالمشكلات). المنهجية: قام الباحث باستخدام المنهج الوصفي التحليلي الارتباطي وذلك نظرًا لملائمة هذا المنهج لطبيعة الدراسة وأهدافها. النتائج: أظهرت نتائج الدراسة أن الدرجة الكلية لواقع الإبداع الإداري لدى رؤساء الأقسام الأكاديمية في الجامعات الحكومية والخاصة في المحافظات الشمالية من فلسطين كانت كبيرة وبوزن نسبي (83%)، وكانت أعلى استجابة على مجال (الأصالة) وبوزن نسبي (84.80%)، بينما كانت أقل استجابة على مجال (الطلاقة) وبوزن نسبي (81.80%)، إضافة إلى أنه لا توجد فروق ذات دلالة إحصائية عند مستوى الدلالة (ألفا أقل أو بساوي 0.05) في الإبداع الإداري لدى رؤساء الأقسام الأكاديمية في الجامعات الحكومية والخاصة في المحافظات الشمالية من فلسطين تُعزى إلى متغيري نوع الجامعة ونوع القسم الأكاديمي والتفاعل بينهما. الخلاصة: أوصت الدراسة بعدة توصيات من أهمها: ضرورة تشجيع إدارات الجامعات رؤساء الأقسام الأكاديمية على الإبداع في العمل، وإعطاؤهم فرص كافية للإبداع دون تقييد لقدراتهم الإبداعية.
Factors Associated with Burnout Syndrome among Clinical Medical Students at Chonburi Hospital, Thailand
Authors: Thamissarakul Supitcha , Hongkan Wasana , Wannapaschaiyong Prakasit
Published: December 2023

Objective: Burnout syndrome causes chronic fatigue, loss of motivation, despair, decreased work performance, and depression. Clinical medical students risk developing burnout syndrome due to long-term learning pressure, responsibilities for patient care and night shifts. This study aimed to examine the factors associated with burnout syndrome among clinical medical students at Chonburi Hospital.Material and Methods: A cross-sectional study was conducted from July 2022 and January 2023. Data were collected using the Maslach Burnout Inventory General Survey among 106 medical students. Descriptive statistics, chi-square, ANOVA, and the independent t-test were used to investigate the association among variables.Results: Severe burnout syndrome was not found among clinical medical students. High emotional exhaustion was the most common burnout symptom among these medical students (53.8%). While 27.3% had high depersonalization, no medical students had low personal accomplishment. The factor related to high emotional exhaustion was 4th-year medical students. At the same time, the factors associated with high depersonalization were fourth-year medical students, males, and low accumulated grade point averages (GPAX).Conclusion: The prevalence of severe burnout was not found among clinical medical students at Chonburi Hospital. However, males, fourth-year medical students, and low GPAX were risk factors for burnout symptoms. Therefore, screening, monitoring, and providing help to these at-risk medical students to reduce their chances of severe burnout should be encouraged.
Changes in the fauna and distribution of birds of the forest-steppe Trans-Urals in the late XX – early XXI centuries under the influence of natural and anthropogenic factors
Authors: Tarasov V.V.
Published: December 2023

The distribution of birds in the West Siberian plain in the western part of the forest-steppe zone (bound east by River Ishim) is very dynamic. Just since the beginning of this century, 16 new breeding species and one possibly breeding species have been discovered in this region. Most of them (76%) are representatives of the Tropical group (5 species) dispersing from the south, as well as the Nomadic (5) and the European (3) types of fauna coming from the south and the west; 3 species belong to the Chinese type of fauna and one – to the Siberian type. Another new species from the Tropical group was recorded as breeding in the last decade of the previous century. The distribution ranges of all 6 representatives of the Tropical group and 2 species of the Nomadic fauna associated with aquatic habitats have expanded northward most over the past 40 years (for 500–600 km). A powerful wave of their dispersal in forest-steppe occurred during the years of maximum filling of water reservoirs in the early 2000s. At the same time, despite the cyclical dynamics of the water level, cyclical processes in the changes of the distribution of limnophile birds are not expressed (analysis of century-long faunal lists shows the cyclical nature of the distribution of no more than 2–3 such species). It is assumed that against the background of intense climate warming most bird species, primarily limnophiles, are not simply redistributing individuals within the ranges, but are expanding their ranges northward, and that expansion will continue in the future. The anthropogenic impact on the regional avifauna is mainly caused by the consequences of the economic crisis in agriculture. In the recent decades, it has been much less obvious than the natural impact.
Endocrine mechanisms controlling the migratory disposition in birds
Authors: Tsvey A.L.
Published: December 2023

On Earth, billions of birds make seasonal migrations every year. Some species fly thousands of kilometers, overcoming seas, mountains and deserts on their way. For migration to be successful, birds must have perfect mechanisms for controlling its beginning, duration and termination. On the way, birds have to make many decisions: how much in energy reserves to accumulate; when to depart, how long and in which direction to fly; how to select optimal weather conditions for flight; and, finally, when and where to terminate migration. Prior to migration, birds develop a migratory disposition – a suite of changes in physiology and behavior (e.g. migratory fattening and expression of nocturnal migratory activity) which are typical for this important life-history stage. Such physiological changes and migratory behavior are the subject of hormonal regulation. The central structure that controls activity of various hormonal systems and development of migratory disposition is the hypothalamic-pituitary system. The hypothalamus controls the secretion of regulatory hormones by the pituitary gland and these hormones, in turn, regulate the activity of downstream endocrine glands. It has been established that spring migratory disposition is triggered by an increasing photoperiod, which stimulates the production of testosterone, prolactin and modulates the signaling of thyroid hormones. In contrast, it is practically unknown how autumn migratory disposition develops when the photoperiod decreases and does not stimulate release of the abovementioned hormones. While in migratory disposition, the endocrine control of behavior on the smaller temporal scales (for example, the level of fuel accumulation, or decision to depart from a migratory stopover) is associated with the combined action of melatonin, corticosterone, insulin, glucagon, adipokines, and other hormones and neurotransmitters. In this review, I will describe the role of these hormones in the control of migratory traits, highlight the existing inconsistencies, and present possible ways to progress in this area of research. A knowledge of endocrine regulation of migratory behavior will help to predict the limits of species adaptability, explain current population trends, and inform conservation actions, which is especially important in the light of modern climate change and anthropogenic transformation of landscapes.
Diet shift in giant Madagascan dung beetle Helictopleurus giganteus (Coleoptera: Scarabaeidae: Scarabaeinae) studied by amplicon metagenomics
Authors: Frolov A.V. , Vishnevskaya M.S. , Akhmetova L.A.
Published: December 2023

Dung beetles are important elements in the food webs in Madagascar, where they evolved as consumers of lemur excrements. The anthropogenic pressure reduces lemur populations, which causes dung beetles to shift to other food sources. To assess the diet of giant Madagascan dung beetle Helictopleurus giganteus (Harold), we studied hindgut content of seven specimens from different localities with amplicon metagenomic methods. We found reads of five mammal species, with over 99% of total reads belonging to human and cow. No native Madagascan mammals were detected in the samples. The results suggest the human mediated diet shift in H. giganteus, although they should be interpreted with caution, because unavoidable contaminations may contribute reasonably to the high yield of the cow and human reads.
Confirmation of the validity of the genus Raritobrilus (Nematoda: Tobrilida) based on the species R. scallensis (W. Schneider, 1925) from Lake Ladoga
Authors: Tsalolikhin S.Ya.
Published: December 2023

The article is devoted to three aspects of the study of free-living freshwater nematodes: 1) the taxonomic position and validity of the genus Raritobrilus due to the unjustified synonymization of this genus; 2) the redescription of the species R. scallensis due to its incomplete primary description and the reduction of the species R. husmanni to synonyms of R. scallensis; the basis for this synonymization was a comparative analysis of the morphology of these species; 3) replenishment of the list of nematofauna of Lake Ladoga.
Вплив комплексного лікування з використанням агоністів дофамінових рецепторів та антагоністів альдостерону на показники добового моніторування артеріального тиску у хворих з артеріальною гіпертензією і супутнім ожирінням
Authors: Lyzogub V. G. , Sobol V. O. , Dolynna O. V. , Kuzminska L. A.
Published: December 2023

In hypertensive patients with concomitant obesity observed decrease in activity of dopaminergic system in conjunction with increased activity of the renin-angiotensin-aldosterone system. Identified changes point to the advisability of appointing this group of patients the dopamine receptor agonist – bromocriptine-KV and antagonist of aldosterone – veroshpiron. As a result of treatment was an increase in dopamine levels in the urine, a decrease of aldosterone in the blood, normalization of the daily blood pressure monitoringn.
Результаты ангиографического исследования коронарных сосудов у больных сахарным диабетом типа 2 и инфарктом миокарда
Authors: Shatokhina I. V.
Published: December 2023

High risk of vascular complications in diabetes foundation gave the American Heart Association ranked diabetes to diseases of the cardiovascular system. More than 60 % of patients with type 2 diabetes life expectancy will be reduced by the development of their coronary artery disease, diabetes was an independent factor that increases the risk of myocardial infarction (2–3 times), stroke (more than 2 times) independently of other known risk factors for cardiovascular disease, and acute coronary events are characterized by the extremely serious nature against the background of pronounced coronary atherosclerosis. In the present study, a comparative assessment of the frequency of coronary vessels of different severity in patients with myocardial infarction in the presence of diabetes and without. Status of the coronary vessels were studied by means of selective coronary angiography. The study found that in patients with myocardial infarction in combination with type 2 diabetes is much more frequent multivessel disease and coronary delay the passage of contrast material than patients with MI without diabetes. These features and characteristics of coronary lesions in patients with diabetes and myocardial infarction may explain why more severe myocardial infarction with frequent development of coronary events in these patients. After analyzing the data obtained, it can be assumed relationship progression of vascular lesions with concomitant coronary glycemic decompensation.
Вплив атоксилу і триглобуліну на цитокіновий баланс та рівень С-реактивного білка у дітей з тяжкою формою бактеріальної ангіни
Authors: Rymarenko N. V.
Published: December 2023

81 children with severe forms of the bacterial anginas passing on endotoxinemia of intestinal origin were examined. Use of preparations atoxil and triglobulin in a complex therapy was accompanied by normalization of cytokine activity and level of C-reactive protein on the background of reduction of concentration endotoxin in blood serum.
Прогнозування перебігу пневмоперитонеуму та тактика хірургічого лікування хворих на гострий і хронічний холецистит із супутньою патологією серцево-судинної системи
Authors: Korotkij V. M. , Solyarik S. O. , Tsiganok A. M. , Sysак O. M.
Published: December 2023

The share of elderly and senile patients with acute cholecystitis concomitant cardiovascular pathology whom the laparoscopic cholecystectomy has been provided is increased. The heightened intraabdominal pressure has negative influence at the cardiovascular system, so the alternative ways for treatment of this group of patients are used in clinic. We propose the pneumoperitoneum model using the pneumatic belt which is fixed at the abdomen in preoperative period in patients with an acute and chronic cholecystitis. This model is useful to forecast cardiovascular disorders during future laparoscopic cholecystectomy. The arterial pressure level, pulse score and ECG are monitored during the test (90 min). Myocardial ischemia appearance seems that the risk of laparoscopic cholecystectomy with pneumoperitoneum is high. The alternative method of surgery in such group of patients (no pneumoperitoneum is applied) is laparoscopic assisted cholecystectomya from miniaccess. This method allows to reducing frequency of intra- and postoperative complications connected with pneumoperitoneum negative influence at the patients with concomitant pathology of cardiovascular system.
Влияние кораргина на реактивность изолированной аорты у взрослых и старых облучённых крыс
Authors: Gorban E. M. , Sykalo N. V. , Podyachenko O. V.
Published: December 2023

Introduction to the diet of adult (7–8 months) and old (24–26 months) male rats for 30 days after a single R-irradiation at a dose of 5 Gy of preparation “Korargin” (whose active ingredients are L-arginine, contributing to the prevention of endothelial dysfunction, and inosine) in old irradiated rats significantly increased the relaxation of isolated segments of thoracic aorta by the action of acetylcholine, sodium nitroprusside and insulin. In adults irradiated animals this effect was not observed. Vasoconstriction response of isolated segments of thoracic aorta to norepinephrine was decreased in isolated segments of thoracic aorta by adults and old irradiated rats compared with controls, and application of korargin had no significant effect. Thus, in old irradiated rats, in contrast to adult irradiated animals, the use of korargin increased of vascular sensitiveness to act of endothelial-dependent and endothelial-nondependent vazodilatators, helped to preserve of endothelial function and increase the capacity of vazodilatator potential.
Вплив солей важких металів на сперматогенну функцію і її корекція препаратом Тивортин®
Authors: Romanyuk A. M. , Saulyak S. V. , Moskalenko R. A. , Moskalenko Yu. V.
Published: December 2023

Entrance of threshold concentrations of copper, zinc, iron, manganese, lead, limp into the body of sexually mature male of rats leads to secretory malfunction of the testicles, which manifests by a decrease of sperm concentration in the ejaculate, a decrease of percentage of motile gametes, an increase in the proportion of morphologically abnormal sperm forms. The evidence of disorders in spermatogram’s parameters is directly depends on the duration of the influence of combination of heavy metal salts. The application of the drug Tivortin® against intoxication of heavy metal salts decrease the adverse movement of quantitative and qualitative parameters of rat’s spermatogramms, so far as Tivortin® improves blood circulation, stimulates cell proliferation and cell differentiation, inhibits oxidative apoptosis. These explain beneficial effects of the drug on the growth and matura-tion of germ cells in case of the influence heavy metal salts combination on organ and the whole body.
Токсичний вплив хіміотерапії на травний канал
Authors: Sivak L. A. , Maidanevich N. M. , Gubareva H. O. , Lyalkin S. O. , Aleksik O. M. , Askolskiy A. V.
Published: December 2023

In modern oncology chemotherapy (CT), along with the surgical technique and radiotherapy is a leader in the treatment of cancer patients. More than 60 % of patients receiving chemotherapy at different stages of treatment. Recently, modern chemotherapy has become more urgent personal approach to the choice of drugs and their doses, aimed at reducing the toxicity of chemotherapy. Complications of chemotherapy significantly degrade the effectiveness of the treatment of patients with malignant tumors, because they require lower doses of anticancer drug, or lengthening the intervals between cycles of chemotherapy, which affects treatment outcomes and quality of life. This paper presents a literature review of toxic effects of cytostatic drugs on the gastrointestinal tract.
К вопросу о парапсориазе: проблемы классификации (обзор литературы и собственные наблюдения)
Authors: Kozlouska V. V. , Khaikova E. A.
Published: December 2023

In the presented article we discuss the problems of lichenoid and plaque parapsoriasis. The differ-ence in Russian and English classifications are discussed in the historical aspect, as well as review of the literature, and personal authors’ observations of nine patients with “small plaque parapsoriasis”.
Стан активності дофамінергічної системи як один з факторів розвитку артеріальної гіпертензіії та ожиріння
Authors: Lyzogub V. G. , Dolynna O. V. , Bogdan T. V. , Sobol V. O.
Published: December 2023

Opening 5 subtypes of dopamine receptors exposed their important role in development of arterial hypertension and obesity. Reduce of their functional activity or number with age conduces to the increase of tone of the sympathetic nervous system, dyspoiesis of leptin, hyperphagia, development of obesity and arterial hypertension. Prescription of dopamine agonists conduces to reduction of in, normalization of leptin, diminishing of appetite and body mass, decrease of blood pressure. Combination of arterial hypertension and obesity is recommended to determine dopamine excretionand to appoint dopamine agonists at level of < 600 nmol/24 hours.
Порівняльна характеристика даних лабораторного дослідження хворих з хронічною серцевою недостатністю ішемічного походження із систолічною дисфункцією лівого шлуночка та його збереженою фракцією викиду
Authors: Dyudina I. O. , Ponomareva T. V. , Paraschenyuk L. P.
Published: December 2023

581 patients with chronic heart failure (CHF) of ischemic origin with systolic left ventricular dysfunction (SLVD) and preserved left ventricular ejection fraction (PLVEF) were examined. The aim of the study was to investigate the comparative aspect of laboratory examination of patients with chronic heart failure of ischemic origin with left ventricular systolic dysfunction and patients with heart failure and preserved left ventricular ejection fraction. The study found no differences in the groups on the basic parameters: the number of white blood cells, hemoglobin concentration, red blood cell count, platelet count, the number of potassium and sodium ions. At the same time, patients with CHF and left ventricular systolic dysfunction characterized by the presence of a moderate decline in glomerular filtration rate, including more frequent patients with lymphocytopenia, hypoholesteremia, hyperuricemia. For patients with chronic heart failure and preserved left ventricular ejection fraction the following characteristics have been characterized: normal or increased glom-erular filtration rate, hypercholesterolemia.
Раціональна антибактеріальна терапія при хірургічному лікуванні хворих з гострим апендицитом
Authors: Bezrodniy B. G. , Kolosovich I. V. , Iovitsa А. V. , Martinovich L. D. , Sidorenko R. A. , Sysak O. M.
Published: December 2023

Character of microflora of exsudate of abdominals and mucosis microflora of vermicular appendix is studied for patients with the destructive forms of appendicitis with the purpose of development of variants of antibacterial therapy at surgical treatment of patients with acute appendicitis. The patients with the destructive forms of appendicitis, which were on treatment in a municipal clinical hospital N 4 Kyiv for period 2004–2010. An Inflammatory-destructive process in an appendix is conditioned by both aerobic (Escherichia coli – 46,6 %, Enterobacter – 4,2 %, Citrobacter – 4,2 %, Klebsiella – 3,3 %, Pseudomonas aeruginosa – 5,8 %, Staphylococcus – 4,2 %) and anaerobic microorganisms (Bacteroides – 100 %) and increase Candida – 17,5 %. Аntibacterial therapy is effective at 46,7 % patients with acute appendicitis. At 49,6 % patients acute appendicitis develops on a background dysbiotic intestinal disturbances. Clinically the effective charts of empiric antibacterial monotherapy 6 days it is been: Moxifloxacini intravenously 400 mgs one time in twenty-four hours during, Ertapenemi for a 1 g one time in twenty-four hours intravenously and combined – Aztreonami for a 1 g twice in twenty-four hours and of Clindamycini for 600 mgs twice in twenty-four hours, intramuscular during; Cefepimumi for a 1 g twice in twenty-four hours and of Clindamycini for 600 mgs twice in twenty-four hours, intramuscular.
Троакарная грыжа: причины возникновения, лечение, методы профилактики
Authors: Ivanko O. V.
Published: December 2023

The paper presents the results of the study 41 patients with trocar hernias after various laparoscopic operations. It is established that the main reason is the expansion of trocar hernia injury when removing the drug without further suturing of the aponeurosis. Proposed closure of the aponeurosis, while the length of the wound more than 2 cm – alloplastica.
Использование фитотерапии при лечении заболеваний щитовидной железы
Authors: Kvachenyuk A. M. , Kvachenyuk E. L.
Published: December 2023

The main tasks during treatment of hyperplastic thyroid diseases – to stop the growth of thyroid nodules; compensation of hypothyrosis; normalization of thyroid size. One of the perspective methods in combine therapy of diffuse and mix goiter is a phytotherapy. The most often for thyroid diseases we have used the plant drug Polentilla alba, which on Ukrainian market was registered as "Alba®". Investigation has shown, that phytodrug of Polentilla alba could be recommended for monotherapy and for combine conservative therapy of diffuse and mix benign euthyroid goiter, and also for complex treatment of toxic and hypothyroid goiters.
Захворюваність військовослужбовців Збройних сил України на хвороби органів травлення
Authors: Rozhkov G. S.
Published: December 2023

The paper presents an analysis of the level and structure of morbidity Armed Forces of Ukraine diseases of the digestive system. The highest rates of total incidence of disease in the class XI 2008–2011, recorded among conscripts, the lowest – in the military under the contract.
Особенности тиреоидной патологии в детском возрасте
Authors: Buryak V. M. , Murashko E. S.
Published: December 2023

The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic processes regulation in the child’s growing organism and often signals to the beginning of many thyropathies.
Мета-анализ рандомизированных исследований антимикробных препаратов в лечении ишемической болезни сердца
Authors: Skochko O. V. , Kaidashev I. P.
Published: December 2023

The meta-analysis of 12 clinical research of application of antibiotics (azithromycin, roxithromycin, clarithromycin, gatifloxacin) in 24 949 patients with coronary heart disease were carried out. The obtained results were shown that application of short courses of antibiotic therapy in patients with severe morphological changes in small coronary vessels were not enough effective. Contrariwise, long-term courses of antibiotic therapy could be effective in patients with initial lesions of blood vessels and presence of chronic infections.
Вплив фенугрека на ріст перещеплених пухлин у експериментальних тварин
Authors: Zhylenko V. V. , Zaletok S. P. , Klenov O. O.
Published: December 2023

This paper deals with antitumor properties of a fenugreek (Trigonella Foenum Graecum L.) as to the different genesis tumors – the Ca755 mouse mammary carcinoma and the Guerin’s carcinoma in rats. Fenugreek powder was shown to inhibit (25–40 %) growth of certain tumors, decrease (27–63 %) level of malone dialdehyde in liver, heart and kidney. Consumption of fenugreek was accompanied with decreased polyamines (spermine, spermidine, putrescine) content in tumor tissue. Inclusion of fenugreek to allowance was shown to improve certain blood value.
Коррекция синдромов нарушения иммунологической реактивности
Authors: Afanas'ev V. V.
Published: December 2023

Factors, able to cause the second immunodeficit, are very various: sharp and chronic poisonings, protracted reception of some medicinal preparations, chronic stress and overstrain. The general line of the factors described higher is the complex negative affecting all systems of organism, including on the immune system. In addition, such factors as an ionizing radiation is also rendered electoral ingibiruyuschee operating on immunity, related to oppressing of the system of krovetvoreniya. Second immunodeficity carry coming character and treatment of second immunodeficitov much simpler and more effective as compared to treatment of primary parafunctions immune system. The restoration capabilities of the immune system are great, therefore the removal of reason of immunodeficit, as a rule, results in renewal of immune system.
Факторы, указывающие на дифференцированный подход в лечении тяжёлых очаговых поражений головного мозга
Authors: Mamytov M. M. , Yrysov D. B. , Mamytova E. M.
Published: December 2023

The frticle is devoted the study of complex research 126 patients with a heavy craniocerebral trauma, accompanied vnutrimozgovoy traumatic haematoma and hearth crushing of cerebrum, passing treatment in the clinic of neuro-surgery. The use of modern diagnostic methods of research considerably changed the informative providing of diagnostic and medical process at the different hearth defeats of cerebrum, including traumatic hearth injuries of cerebrum. The long-term looking after intracraneal haematomas allowed to mark that haematomas suffer successive changes which are expressly traced on computer tomography researches in course of time.
Герпетичний енцефаліт: клінічний випадок
Authors: Drygant L. P. , Sereda V. G. , Kushpiy O. V. , Tkachenko V. V. , Kravchuk N. A. , Ingula N. I. , Sizina A. V. , Sachko Y. Y. , Andrusenko A. S. , Titenko Y. I. , Babirad A. M.
Published: December 2023

An example of diagnostics and treatment of patient is in-process made with herpetic encepha-litis. It is well-proven in researches, that a herpetic encephalitis is 11,5 % among sharp encephali-tises. Morbidity is sporadic, some researchers specify on an increase its spring. An infection can be passed tiny and pin a way. Seasonal vibrations are not incident to the herpetic encephalitis. Two peaks of morbidity are on 5–30 years and age more senior 50 years. More than in 95 % cases the virus of simple herpes of type serves as an exciter of herpetic encephalitis 1. A characteristic triad of herpetic encephalitis is the sharp feverish beginning, development of cramps of dzheksonovskogo type and violation of consciousness, developing usually after a brief respirator infection. Sometimes sudden development of cramps and loss of consciousness is preceded a fever. Example of such de-velopment of disease is made an in our work.
Діагностика та комплексне лікування головного болю, пов’язаного з гострою інфекцією оперізуючого герпесу (Herpes zoster)
Authors: Mikitey O. M.
Published: December 2023

Classification (on a nosotropic mechanism) on which distinguish head pain is in-process resulted: vascular, head pain of tension, likvorodinamicheskaya, neuralgic, mixed type, and also facial pains and pains in area of ear. Duration – from a few clock to a few days. Such state can be at hypertensive illness, allergic reaction, fervescence. When GB appears in set time during a few days, large authenticity that it is a vascular type. It is expedient to apply the holiatry of head pain, related to the sharp infection of girdle herpes (Nerpes zoster), antiviral, kortikosteroidnimi, nesteroidnymi protivovospalitel’nymi preparations, antidepressants, methods of refleksoterapii.