bluuebunny/crossref_metadata_2025 huggingface dataset:
A Step Towards a Reinforcement Learning De Novo Genome Assembler
Authors: Padovani Kleber , Xavier Roberto , Carvalho André , Reali Anna , Chateau Annie , Alves Ronnie
Published: July 2021

Genome assembly is one of the most relevant and computationally complex tasks in genomics projects. It aims to reconstruct a genome through the analysis of several small textual fragments of such genome — named reads. Ideally, besides ignoring any errors contained in reads, the reconstructed genome should also optimally combine these reads, thus reaching the original genome. The quality of the genome assembly is relevant because the more reliable the genomes, the more accurate the understanding of the characteristics and functions of living beings, and it allows generating many positive impacts on society, including the prevention and treatment of diseases. The assembly becomes even more complex (and it is termed de novo in this case) when the assembler software is not supplied with a similar genome to be used as a reference. Current assemblers have predominantly used heuristic strategies on computational graphs. Despite being widely used in genomics projects, there is still no irrefutably best assembler for any genome, and the proper choice of these assemblers and their configurations depends on Bioinformatics experts. The use of reinforcement learning has proven to be very promising for solving complex activities without human supervision during their learning process. However, their successful applications are predominantly focused on fictional and entertainment problems-such as games. Based on the above, this work aims to shed light on the application of reinforcement learning to solve this relevant real-world problem, the genome assembly. By expanding the only approach found in the literature that addresses this problem, we carefully explored the aspects of intelligent agent learning, performed by the Q-learning algorithm, to understand its suitability to be applied in scenarios whose characteristics are more similar to those faced by real genome projects. The improvements proposed here include changing the previously proposed reward system and including state space exploration optimization strategies based on dynamic pruning and mutual collaboration with evolutionary computing. These investigations were tried on 23 new environments with larger inputs than those used previously. All these environments are freely available on the internet for the evolution of this research by the scientific community. The results suggest consistent performance progress using the proposed improvements, however, they also demonstrate the limitations of them, especially related to the high dimensionality of state and action spaces. We also present, later, the paths that can be traced to tackle genome assembly efficiently in real scenarios considering recent, successfully reinforcement learning applications — including deep reinforcement learning — from other domains dealing with high-dimensional inputs.
Syringol Isolated From Eleusine Coracana (L.) Gaertn Bran Suppresses Inflammatory Response Through the Down-Regulation of cPLA2, COX-2, IκBα, p38 and MPO Signaling in sPLA2 Induced Mice Paw Edema.
Authors: Gowda Mallanayakanakatte D. Milan , K Jayachandra , Joshi Vikram , Manjuprasanna Vaddarahally N. , Rudresha Gotravalli V. , Velmurugan Devadasan , Pachaiappan Raman , Jameel Noor Mohamed , Vishwanath Bannikuppe S.
Published: July 2021

Eleusine coracana (L.) Gaertn (E. coracana) is one of the highest consuming food crops in Asia and Africa. E. coracana is a plant with several medicinal values including anti-ulcerative, anti-diabetic, anti-viral and anti-cancer properties. However, the anti-inflammatory property of E. coracana remains to be elucidated. Therefore, the objective of present study was to investigate the potential in isolated molecule from E. coracana via a combination of in vitro, in vivo and in silico methods. In this study we have isolated, purified and characterized an anti-inflammatory molecule from E coracana bran extract known as syringol. Purification of syringol was accomplished by combination of GC-MS and RP-HPLC techniques. Syringol significantly inhibited the enzyme activity of sPLA2 (IC50 = 3 µg) and 5-LOX (IC50 = 0.325 µg) in vitro. The inhibition is independent of substrate concentration, calcium ion concentration and was irreversible. Syringol interacts with purified sPLA2 enzymes as evidenced by fluorescence and molecular docking studies. Further, the syringol molecule dose dependently inhibited the development of sPLA2 and carrageenan induced edema. Furthermore, syringol decreases the expression of cPLA2, COX-2, IκBα, p38 and MPO in edematous tissues as demonstrated by western blots. These studies revealed that syringol isolated from E coracana bran may develop as a potent anti-inflammatory molecule.
Selected ‘Starter Kit’ energy system modelling data for Indonesia (#CCG)
Authors: Allington Lucy , Cannone Carla , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Brown Edward , Howells Mark , Niet Taco , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Wogan David , Barcelona Edito , Rogner Holger
Published: July 2021

Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Indonesia, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Analysis of free fatty acids in plasma for the prognosis of cardiovascular events after acute myocardial infarction: study protocol for prospective, observational, single-center cohort trial.
Authors: Chen Weiwei , Wang Shuang , Yan Xu , Sun Huan , Yang Ping
Published: July 2021

• Background• It is not currently known whether free fatty acids can be used as predictors for the prognosis of patients with acute ST-segment elevation myocardial infarction. The results of many studies on the correlation between free fatty acids and the prognosis of patients with acute myocardial infarction are inconsistent. The purpose of this clinical study is to determine the predictive effect of different free fatty acids in the plasma on cardiovascular events within the 12 months after a patient suffers an acute ST-segment elevation myocardial infarction.• Methods• This study is a prospective, observational, single-center cohort study. After enrollment, all participants will receive standard treatment and will be tested for 31 kinds of plasma free fatty acids. The patients will be followed up 2, 6, and 12 months after discharge. The primary endpoint is the compound cardiovascular events from onset to 12 months, including the cumulative incidence of all-cause death, heart failure, or coronary revascularization events. According to the power and sample size calculation, it will be necessary to enroll 747 patients in this study. After follow-up, data will be collected and analyzed to explore the predictive effect of different free fatty acids in plasma on the prognosis of acute elevated ST-segment myocardial infarction, and the risk factors of the endpoint events within 12 months.• Discussion• This study will provide new insightful evidence of serum indicators indicating the 12-month cardiovascular events of acute ST-segment elevation myocardial infarction.Trial registration: This study was retrospectively registrated at Chinese Clinical Trail Registry (https://www.chictr.org.cn/) on 14th July,2021. Registration number: ChiCTR2100048731.
Avaliação do cenário de distribuição de Cirurgiões-Dentistas por especialidades odontológicas no estado da Paraíba, Brasil
Authors: Silva André Rodrigo Justino da , Silva Rodivan Braz da
Published: July 2021

Introdução: A situação do mercado de trabalho para o Cirurgião-Dentista vem passando por um período de mudanças com aumento da competitividade, predominância do gênero feminino e crescimento do número de especialistas. Objetivo: Caracterizar a distribuição dos cirurgiões-dentistas no estado da Paraíba, no Nordeste brasileiro, de um modo geral, porém com enfoque nas especialidades odontológicas registradas no Conselho Regional de Odontologia. Material e Método: Realizou-se levantamento de dados baseado em pesquisa documental a partir de arquivos públicos com coleta de dados do número de especialistas no estado da Paraíba, com apresentação quantitativa e percentual de cada especialidade de acordo com os sites dos conselhos regional e federal de odontologia. Resultados: Os dados obtidos apontam o total de 5.120 cirurgiões-dentistas registrados no estado da Paraíba, dos quais 1.013 possuem registros como especialistas ativos em 22 especialidades com a predominância do gênero feminino. Assim, a proporção entre profissionais e população a nível estadual é de aproximadamente 1 cirurgião-dentista para cada 735 pessoas. A especialidade com maior registro pelo gênero masculino é a de Cirurgia e Traumatologia, enquanto para o gênero feminino é a Endodontia. As cinco especialidades odontológicas que mais predominam em número geral consistem, em ordem decrescente, em Endodontia, Prótese dentária, Ortodontia, Cirurgia e Traumatologia Bucomaxilofacial e Periodontia. Conclusão: Pode- se concluir que há o predomínio feminino no mercado de trabalho odontológico na Paraíba. Além disso, a especialidade com maior número de profissionais ativos no estado é a Endodontia, sendo também a de maior adesão pelo gênero feminino.
Prevalência de fluorose e concentração de fluoreto em água potável
Authors: Riatto Sabrina Gonçalves , Luna Vitor Matheus da Silva
Published: July 2021

Introdução: Na odontologia, o íon flúor, também conhecido como fluoreto, apresenta efeitos profiláticos e terapêuticos, porém pode trazer riscos. A sua utilização em águas de abastecimento público e em outros produtos deve ser entendida e controlada para minimizar efeitos indesejados às dentições, como a fluorose dentária. O monitoramento da fluorose em um país tem sua importância para comprovar se as cifras estão estabilizadas, uma vez que se conhece um crescente potencial imigratório mundial. Objetivo: Revisão da literatura dos últimos anos, buscando informações sobre a relação entre a concentração de fluoreto em água natural potável e a prevalência de fluorose em variadas populações de diferentes países. Materiais e Métodos: Buscaram-se publicações nas principais bases de dados: Scopus, Portal Periódicos Capes, Scielo, Biblioteca Virtual em Saúde, PubMed e Google Acadêmico, através das palavras-chave: Fluorose dentária, Flúor, Fluoreto, Epidemiologia e Água potável, nos idiomas português, espanhol e inglês. Dos 38 artigos selecionados, 29 foram utilizados no presente trabalho. Resultados: Dos países estudados, a Etiópia (com 12 partes por milhão de Flúor na água potável) obteve maior índice de fluorose dentária (100% da amostra), e o menor índice de fluorose foi encontrado na Síria (1.39 partes por milhão de Flúor na agua potável), equivalente a 15%. Conclusão: Pôde-se concluir que a prevalência e a severidade da fluorose dentária geralmente são maiores nas populações que vivem em regiões com altas concentrações de fluoreto na água natural potável.
Efeitos adversos da toxina botulínica sobre parâmetros ósseos e musculares: revisão integrativa da literatura
Authors: Barba Danielle Sangalli Dalla , Machado Gabriela Moraes , Brew Myrian Camara , Bavaresco Caren Serra
Published: July 2021

Introdução: A toxina botulínica do tipo A tem sido utilizada amplamente como opção terapêutica para o bruxismo. Todavia, é importante discutir o seu efeito nos parâmetros ósseos e musculares. Objetivo: Conhecer, através de revisão integrativa de literatura, os possíveis efeitos adversos da administração terapêutica da toxina botulínica sobre parâmetros ósseos e musculares em modelos animais e humanos. Método: Foi realizada uma busca por artigos nas bases de dados Lilacs, PubMed, Scielo e Google Acadêmico, tendo como descritores os termos “botulinum toxin and bone and masticatory muscles”, na língua inglesa e os termos toxina botulínica e osso e músculos mastigatórios, em português. A inclusão dos artigos nesta revisão obedeceu a critérios de inclusão e exclusão. Resultados: Foram encontrados 283 artigos nas bases de dados consultadas, sendo 261 artigos excluídos por título, e nenhum artigo foi excluído por resumoe após sua leitura na íntegra. Um total de 22 artigos fizeram parte desta revisão. Conclusão: Estudos em ratos apontam para alterações esqueléticas e musculares após administração da BTX-A, mesmo comuso único, o que pode resultar em perda óssea a curto e longo prazo e, assim, potencializar problemas futuros. Mais estudos controlados randomizados deveriam ser realizados em humanos para melhores esclarecimentos sobresos efeitos da BTX-A nas estruturas ósseas.
Malformação capilar jugal x trauma parafuncional: relato de caso e tratamento
Authors: Cativo Juliana dos Santos , Cabral Lioney Nobre , Pinheiro Tiago Novaes , Vieira Myrian Salles , De Araujo Vasconcelos II Antonio Jorge
Published: July 2021

As malformações vasculares são anomalias estruturais dos vasos sanguíneos sem proliferação endotelial, estão presentes ao nascimento e persistem ao longo da vida. Elas podem ser categorizadas de acordo com o tipo de vaso envolvido (capilar, venoso, arteriovenoso) e de acordo com as características hemodinâmicas (baixo fluxo ou alto fluxo). Possuem uma etiologia variável, como fatores químicos, mutações genéticas ou alterações relacionadas a síndromes, fluxo sanguíneo, resistência da parede vascular e trauma. Neste caso, a malformação vascular apresentada pela paciente tem relação com o trauma em mucosa jugal devido a atividade parafuncional presente. Atividade parafuncional refere-se a qualquer atividade que não seja considerada funcional, como apertar e/ou ranger os dentes durante o dia e/ou à noite, mascar chicletes, morder bochecha, lábios e língua. Algumas destas atividades podem ser responsáveis por concorrer para a Disfunção Temporomandibular (DTM), pois promovem hiperatividade muscular mastigatória. Dor muscular, restrição de abertura de boca, sensação de plenitude auricular, zumbido na orelha e vertigem foram alguns dos sintomas apresentados pela paciente. Diante desse quadro, além de tratar a malformação vascular com uma combinação de escleroterapia e excisão cirúrgica, foi também tratado o quadro disfuncional, para seu controle e resolução além da prevenção de recidiva da lesão, com a utilização de placa miorrelaxante combinada com a realização de exercícios fisioterápicos, mostrando-se eficazes, contendo a sintomatologia, restringindo a atividade parafuncional e reduzindo o trauma na mucosa.
Itinerários terapêuticos dos pacientes com câncer de cabeça e pescoço: revisão integrativa da literatura
Authors: Cunha Cíntia Hein de Oliveira , Kasper Rafaela Hartmann , Machado Gabriela Moraes , Bavaresco Caren Serra
Published: July 2021

Introdução: No Brasil, pacientes com câncer de cabeça e pescoço percorrem diversas instâncias de saúde de forma equivocada. Conseguindo a adesão ao tratamento apropriado, em muitos casos, de forma tardia. Objetivo: Realizar uma revisão integrativa sobre o itinerário terapêutico de pacientes com câncer de cabeça e pescoço na rede de atenção básica. Material e método: Foram realizadas buscas na base de dados MEDLINE, PubMed, LILACS, Scielo e Google Acadêmico, tendo como descritores os termos: “therapeutic itinerary”, “head and neck cancer”, “Health Unic System”. Foram excluídas revisões de literatura e artigos sem relação com o tema. Resultados: Todos artigos selecionados observaram a demora no diagnóstico e tratamento. Na maioria dos casos de carcinoma de cabeça e pescoço que são atendidos dentro da rede de atenção básica à saúde, o diagnostico ocorre tardiamente e/ou erroneamente. Conclusão: Observou-se que a demora do diagnóstico e tratamento está ligada basicamente a dois fatores: à falhas no sistema de saúde e a reação e decisões do paciente frente a sua saúde. Pudemos observar que existem grandes falhas no sistema de saúde, como a comunicação. Essas falhas contribuem para o atraso no diagnóstico gerando certo descaso com a vida dos pacientes. Por outro lado, notamos que outra boa parte do processo de cura e descobrimento da doença está ligado com o interesse e reação dos usuários diante do seu diagnóstico, suas decisões de curas alternativas ou desinteresse de busca por saúde agravam o seu estado.
LLLT e avulsão dentária: implicações nas propedêuticas endodônticas e periodônticas
Authors: De Moraes Larissa dos Santos , Martins Christine Men
Published: July 2021

Introdução: Um dos principais traumatismos dentários com graves consequências que acomete a população é a avulsão dentária, caracterizada pela completa exarticulação do dente para fora do seu alvéolo. Como consequência desse trauma, as fibras do ligamento periodontal, cemento e polpa são agredidas e pode ocorrer a reabsorção radicular. Devido à eficácia do uso da laserterapia de baixa potência (low level laser therapy – LLLT) em tratamentos periodontais e endodônticos, seu uso parece promissor em casos de avulsão dentária, podendo aumentar as taxas de sucesso. Objetivo: Realizar revisão narrativa para compreender a ação do LLLT sobre as propedêuticas endodônticas e periodonticas; apresentar o conhecimento atual e científico sobre a eficácia da LLLT na avulsão dentária; e observar falhas de pesquisas sobre o tema. Revisão de literatura: O LLLT reduz a dor pós-operatória na terapia e retratamento do canal radicular, tendo uma diminuição significativamente maior em relação aos anti-inflamatórios. Na periodontia há a redução de bactérias e cálculos, neutralização de endotoxina e diminuição de profundidade de bolsas. Poucos estudos avaliaram sua aplicação em tratamentos para reimplante dentário, os quais mostraram uma melhora a cicatrização, aumento na espessura da camada de dentina reacional e diminuição da inflamação. Considerações finais: A irradiação do LLLT promove reações bioquímicas, originando a estimulação do reparo tecidual, regeneração e redução dos processos inflamatórios, podendo ser um tratamento promissor para casos de avulsão e reimplante dentários. Mais pesquisas devem ser realizadas.
Dilute initial dentofacial abscess of buccal space: a technical note
Authors: Berardi Rogerio Henrique , Ogoshi José Lineu Pereira , Horikawa Fernando Kendi , Yokoyama Plinio Jun Iti , Snidei Iron Ricardo Machado , Shinohara Elio Hitoshi
Published: July 2021

The treatment of the dentofacial abscess was always surgical because the evacuation of the purulent collection and removal of the cause are mandatory. Large abscesses, especially those that reach the submandibular space, require laboratory and imaging exams, but small abscesses restricted to the buccal space can be successfully treated by diluting the purulent collection with saline solution using needle and syringe.
Global Illicit Financial Flows: Where does Dirty Money from Developing Countries become legal?
Authors: Wahaj Ahmed Khan  , Jawaid Syed Tehseen , Shamim  Muhammad Asif
Published: July 2021

The study determines most favorite destinations for money laundering preferred by wrong doers from 25 developing nations selected on the basis of highest illegal financial fund outflows from 2004 to 2014, a report published by Global Financial Integrity (GFI) in 2015. Firstly, it has been discussed that how money laundering activities are shackling the economic and financial stability in a country by distorting and damaging different sectors of economy as well as financial sector. Walker's Gravity Model has used to determine the most preferred destinations for money laundering. Research indicates that most developed and stable economies with lax controls are preferred by criminals. Robustness has been checked through triangulation method. It is recommended that uniform controls at global level are essential to eliminate havens and the need of international body which shall be responsible for policy making and enforcement of strong regulations is also highlighted.
Moderating Role of Person Job-Fit Facet between Hierarchical Plateau and Turnover Intention
Authors: Kumar Ramesh , Akbar Waqar , Khan Naveed R.
Published: July 2021

This study aims to examine the impact of hierarchical plateau on turnover intention with moderating role of person job-fit facet. Hierarchical plateau is a point of an individual's career life where the probability of being promoted further is low. The theory of work adjustment (TWA) is applied in this research study which measures that satisfaction level of an employee and leaving a company when needs and desired system of the person and the organization system mismatched at the workplace. Overall 260 employees participated by filling the self-administrated questionnaires from three different industrial sectors of Karachi, Pakistan including banking sector, pharmaceutical and insurance employees but result of completely and accurately filled questionnaires of 223 employees were tested. The results are generated through using Structural Equation Modeling (PLS-SEM) technique. The results show that hierarchical plateau has positive impact on turnover intention. However, moderating role of person job fit facet (neither demand abilities nor need supplies) moderates' relationship between independent and dependent variable. This study provides a model to management leaders and practitioners who can extremely look into this growing issue not only in Pakistan but worldwide. Certain actions need to be implemented by management to foster a positive attitude towards turnover intention through proper recruitments, development strategies and career training programs over the span of time. Furthermore, the study also provides the guidelines to HR departments to design the policies to resolve hierarchical plateau issues in their organization.
Analyzing health risks caused by contaminated drinking water (experience gained in Samara region)
Authors:   Samara State Medical University, 89 Chapayevskaya Str., Samara, 443099, Russian Federation, Sazonova O.V. Sazonova , Sergeev A.K. ,   Samara State Medical University, 89 Chapayevskaya Str., Samara, 443099, Russian Federation, Chupakhina L.V. ,   Center for Hygiene and Epidemiology in Samara Region, 1 Georgiy Mitirev lane, Samara, 443079, Russian Federation, Ryazanova T.K. ,   Samara State Medical University, 89 Chapayevskaya Str., Samara, 443099, Russian Federation, Sudakova T.V. ,   Samara State Medical University, 89 Chapayevskaya Str., Samara, 443099, Russian Federation,   Samara State Technical University, 244 Molodogvardeyskaya Str., Samara, 443100, Russian Federation
Published: July 2021

Environmental contamination is still a pressing issue, in particular, contaminated drinking water sources and contaminated drinking water from centralized communal water supply systems, since it produces negative effects on human health. Our research goal was to estimate probable impacts exerted on overall morbidity in Samara by quality of drinking water taken from centralized communal water supply systems as a most significant environmental factor. Our research tasks included taking and analyzing drinking water samples from centralized communal water supply systems; calculating carcinogenic and non-carcinogenic health risks caused by analyzed chemicals. To fulfill the tasks and achieve the goals, in 2018–2019 we performed sanitary-chemical analysis of drinking water quality as per 20 sanitary-chemical parameters; our research object was drinking water taken from centralized communal water supply systems in 7 districts in Samara. Obtained actual data on contamination of water taken from centralized water supply networks in Samara were used as primary basis for calculating hazard indexes and carcinogenic risk coefficients using conventional exposure scenarios. In our research we revealed that maximum total non-carcinogenic hazard quotient was determined by arsenic and petroleum products introduction. Assessment of carcinogenic risks caused by contaminants in drinking water revealed that total health risk for children younger than 18 was within the second range as per its median; total carcinogenic risks for adults, within the third range. At the same time, arsenic contents did not exceed hygienic standards in all examined samples. So, we assessed carcinogenic and non-carcinogenic risks, basing on actual data on quality of drinking water taken from centralized communal water supply systems. It seems vital to perform a wider-scale controlled study in several regions in order to assess significance of revealed factors for morbidity among population.
Orzeczenie w sprawie nullitatis matrimonii – i co dalej? Franciszek do Roty Rzymskiej z okazji inauguracji nowego Roku Sądowego 2021
Authors: Góralski Wojciech
Published: July 2021

29 stycznia 2021 roku, w czasie uroczystej inauguracji kolejnego Roku Sądowego w Rocie Rzymskiej, Papież Franciszek, w czasie audiencji dla audytorów i innych urzędników rotalnych, wygłosił przemówienie. Papież zaapelował do sędziów, aby nie zapominali, że integralne dobro osoby wymaga od nich, aby nie pozostawali obojętni wobec przykrych konsekwencji, jakie może spowodować orzeczenie o nieważności małżeństwa. Ojciec Święty postawił pytanie: Co się stanie z dziećmi i małżonkiem, który nie akceptuje nieważności małżeństwa? Jest bardzo pilne, aby biskupi, sędziowie, proboszczowie i inni duszpasterze dołożyli wszelkich starań, aby pomóc opuszczonym małżonkom i ich dzieciom.Na zakończenie przemówienia Franciszek wyraził uznanie dla pracy Roty Rzymskiej i podziękował emerytowanemu dziekanowi za pełnienie posługi z pełnym poświęceniem.
Zaburzenia nastroju jako przyczyna niezdolności osoby do podjęcia istotnych obowiązków małżeńskich
Authors: Nowakowski Bartosz
Published: July 2021

W artykule omówiono wpływ zaburzeń nastroju na niezdolność osoby do podjęcia istotnych obowiązków małżeńskich. Najpierw autor przedstawia dwa podstawowe typy omawianego zjawiska: typ depresyjny i typ maniakalny. Następnie aplikuje omówione zjawisko do kanonicznego prawa małżeńskiego, dotyczącego procesów o stwierdzenie nieważności małżeństwa.
Parafilia a nieważność małżeństwa kanonicznego w wybranych publikacjach
Authors: Szymańska Kinga
Published: July 2021

Z przeprowadzonych analiz wynika, że przedstawiciele doktryny prawa kanonicznego traktują parafilie jako zagrożenie dla małżeństwa i rodziny, traktując je jako przykład dezintegracji psychoseksualnej danej osoby. Zdaniem kanonistów omawiane odstępstwa mogą uniemożliwić zawarcie ważnego przymierza małżeńskiego ze względu na niezdolność parafilika do podjęcia i wypełnienia istotnych obowiązków małżeńskich, takich jak: ustanowienie małżeńskiej wspólnoty życia, ustanowienie więzi międzyosobowej między małżonkami, utrzymanie stałego, wiernego, wzajemnego i długotrwałego związku w celu utrzymania wspólnoty heteroseksualnej, urodzenia i wychowania potomstwa lub urzeczywistnienia współżycia intymnego humano modo. Jednak sama obecność parafilii nie przesądza o niezdolności osoby do zawarcia małżeństwa. W tym zakresie kanoniści zalecają uwzględnienie stopnia nasilenia danej anomalii, odwołując się tym samym do badań Urbano Navarrete i włoskiego psychiatry Gianfrancesco Zuanazziego. Jednocześnie należy unikać pochopnej oceny wagi danej parafilii i uważnie oceniać każdą przedstawioną sprawę, biorąc pod uwagę rodzaj odchylenia, jego cechy, a także osobowość kontrahenta.
Osobowość niedojrzała a zdolność do wyrażenia zgody małżeńskiej. Wpływ rodziny pochodzenia na kształtowanie dojrzałości osoby
Authors: Zyskowska Emilia
Published: July 2021

Wiele spraw o stwierdzenie nieważności małżeństwa jest prowadzonych z tytułu niezdolności do podjęcia istotnych obowiązków małżeńskich z przyczyn natury psychicznej (kan. 1095 n. 3 KPK/83). W znacznej części przypadków małżeństwo zostaje uznane za nieważne z powodu niedojrzałej osobowości jednej lub obu stron, która sprawia, że nupturienci od samego początku nie są w stanie podjąć podstawowych obowiązków małżeńskich. Każdy przypadek powinien zostać jednak rozpatrzony bardzo ostrożnie, ponieważ punkt osiągnięcia dojrzałości jest jedynie umowny, a kształtowanie osobowości trwa całe życie.Artykuł ma na celu omówienie możliwych uwarunkowań osobowości niedojrzałej, kształtowanej przez rodzinę pochodzenia. Rodzina kształtuje podstawowe zręby osobowości dziecka, m.in. system postaw i potrzeb, sposoby ich zaspokajania oraz niezwykle ważny mechanizm samooceny. Dzieci wychowujące się w rodzinach dysfunkcyjnych podlegają wpływowi stresogennych i patogennych czynników, stanowiących źródło głębokich urazów psychicznych, powodujących zmiany w strukturze osobowości oraz problemy emocjonalne i zaburzenia w zachowaniu.
Wykluczenie dobra potomstwa oraz bojaźń szacunkowa w wyroku c. Ferreira Pena z dnia 18 kwietnia 2012 roku
Authors: Kamiński Rafał
Published: July 2021

W zaprezentowanym opracowaniu Autor skomentował wyrok Roty Rzymskiej c. Ferreira Pena z 18 kwietnia 2012 roku. Na stopniu rotalnym sprawa była rozpatrywana z tytułu symulacji częściowej (exclusio boni prolis) oraz z tytułu ciężkiej bojaźni (metus reverentialis).W części prawnej rotalnego orzeczenia wykazano m. in. związek między okolicznościami życia przedmałżeńskiego oraz przyczyną symulacji konsensu małżeńskiego, do zaistnienia którego potrzebny jest pozytywny akt woli. Wskazano także na absorbcję tytułów symulacji i bojaźni, stąd też odstąpiono od orzekania z tego drugiego tytułu. W części faktycznej natomiast ponens wskazał, że nieważność małżeństwa udowodniono przy zastosowaniu zarówno dowodzenia bezpośredniego, jak i pośredniego. W prowadzonej sprawie wykazano, iż tym co skłoniło pozwaną do symulacji, był brak miłości do pozwanego oraz poddanie się okolicznościom życia rodzinnego i presji społecznej. Udowodniono też, iż wykluczenie potomstwa przez pozwaną, było ściśle związane ze stałą praktyką przyjmowania środków antykoncepcyjnych.
Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review
Authors: Pradhan Anil K. , Tripathy Bimala , Chowdhury Bimalendu , Acharjya Sasmita K. , Das Rajaram
Published: July 2021

Background:

The exact pathogenesis of Alzheimer’s disease is still a matter to debate. Currently
there is no reliable therapy established for Alzheimer’s disease. However, several pieces of evidence
suggest that the use of plant based phytoconstituents mainly delays the onset of Alzheimer’s
disease. So, in this review, we collect information about the cause of Alzheimer’s disease hypothesis
and the neuroprotective effect of phytoconstituents.

Objective:

This review paper aimed to analyze the current pathogenesis of Alzheimer’s disease and
therapeutic effect of plant phytoconstituents that play a vital role in neuroprotective and antistress activities
in Alzheimer’s disease and other neurodegenerative disorders.

Methods:

The source of literature review obtained from Scopus, Science Direct, PubMed, Web of
Science database, and journal by using Alzheimer’s pathogenesis, neuroinflammation, oxidative
stress, amyloid beta, flavonoids, alkaloids are an important part of these review research.

Results:

The current review explored different types of pathogenesis involved in Alzheimer’s disease
and the role of phytoconstituents in its treatment. The collected information showed that plant based
constituents inhibit the major cause of Alzheimer’s disease related to amyloid beta, tau protein, oxidative
stress, neuroinflammation, etc.

Conclusion:

The study provides the clue for the investigation of eminent bioactive constituents may
serve as an alternative candidate against Alzheimer’s disease and other neurodegenerative disorders.
Readability of Online Patient Education Materials for Dental Radiology
Authors: Yeung Andy Wai Kan
Published: July 2021

Background:

Dental patients may seek and read online patient education materials pertaining
to dental radiology.

Objective:

The objective of this study was to quantitatively evaluate the readability of online patient
education materials pertaining to dental radiology.

Methods:

All patient education articles available in 2021 from professional societies and authoritative
bodies related to dental radiology were reviewed. Each article was assessed using the Gunning
Fog index, Coleman Liau index, Flesch-Kincaid Grade level, Automated Readability index (ARI),
Simple Measure of Gobbledygook (SMOG) and Flesch Reading Ease score. Contextual information
was recorded in terms of the perspective from which the webpage was written (first, second, or
third-person perspective), modalities mentioned (bitewing, periapical, occlusal, panoramic, cephalometric,
or cone beam [CB] CT/CT), any radioprotection measures explained (for general, pregnancy,
or children), and indications of imaging mentioned.

Results:

Nine relevant webpages were identified. None of the major dental radiology associations
(except the United States one) provided such online information. All but one required about a tenth-
grade reading level to understand the content easily.

Conclusion:

None of the webpages fulfilled the recommendations from the National Institute of
Health and the American Medical Association of being written below a seventh-grade level. More
online patient education materials for dental radiology were recommended, and they should be written
in a more easily understood way.
Edukacja dzieci i młodzieży mniejszości polskiej pod patronatem Polsko-Katolickiego Towarzystwa Szkolnego na Warmię w Prusach Wschodnich / Der polnisch-katholische Schulverein für Ermland
Authors:   Uniwersytet Warmińsko-Mazurski w Olsztynie, Radziszewska Maria
Published: July 2021

Sto lat temu, w pruskim Olsztynie powstało Polsko-Katolickie Towarzystwo Szkolne na Warmię. Wydarzenie to było szczególne w dziejach ziemi warmińskiej, gdyż chodziło o pierwszą lokalną inicjatywę ruchu polskiego na tym terenie, która oficjalnie, mając podmiotowość prawną, zajęła się organizacją szkolnictwa dla mniejszości polskiej w obrębie państwowości niemieckiej. Towarzystwo jako organizacja społeczna poprzez zapewnienie nauczania języka ojczystego zmierzało w kierunku wychowania narodowego oraz wychowania opartego na zasadach religii katolickiej.
Próba kontynuacji pracy wychowawczej przez Towarzystwo Salezjańskie w okresie II wojny światowej
Authors:   Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie, Niewęgłowski Jan
Published: July 2021

Odzyskanie niepodległości przez nasz kraj w 1918 r. otworzył szerokie możliwości na działanie Kościoła, w tym również Towarzystwa Salezjańskiego. Zgodnie z charyzmatem ks. Jana Bosko salezjanie w sposób szczególny angażowali się na polu oświaty i wychowania. Otworzyli kilkanaście szkół ogólnokształcących, zawodowych i sierocińców. Powyższą działalność zahamował wybuch II wojny światowej. Polskę podzielono na trzy strefy. Pierwsza została włączona w struktury III Rzeszy. Druga stanowiła Generalne Gubernatorstwo. Trzecia strefa znalazła się pod okupacją sowiecką. Najtrudniejsze warunki panowały w tzw. Warthegau, gdzie stopniowo zamknięto wszystkie salezjańskie placówki szkolne i wychowawcze. Stosunkowo największą swobodą cieszyło się Generalne Gubernatorstwo. Wykorzystując oficjalne struktury kościelne organizowali tajne nauczanie, ukrywali ludność pochodzenia żydowskiego i starali się prowadzić pracę młodzieżą w miarę możliwości i warunków.
Использование эффекта отрицательного магнитосопротивления в кремнии для создания многофункциональных датчиков
Authors: Бахадырханов М.К. , Илиев Х.М. , Мавлонов Г.Х. , Ибодуллаев Ш.Н. , Тачилин С.А.
Published: July 2021

Установлено, что особенностью отрицательного магнитосопротивления в кремнии, содержащем нанокластеры атомов марганца, является его высокая чувствительность к различным внешним воздействиям. Определены закономерности изменения отрицательного магнитосопротивления в кремнии, содержащем нанокластеры атомов марганца, в зависимости от температуры, освещенности, величины электрического и магнитного полей. Показана возможность создания нового класса многофункциональных датчиков физических величин на основе единого кристалла кремния, содержащего нанокластеры атомов марганца. Ключевые слова: многофункциональный датчик, отрицательное магнитосопротивление, кремний, нанокластер, марганец.
Влияние состава низкотемпературной азотной плазмы на гидрофильные и гидрофобные свойства покрытий на основе азотированного оксида титана
Authors: Муслимов А.Э. , Гаджиев М.Х. , Эмиров Р.М. , Исмаилов А.М. , Каневский В.М.
Published: July 2021

Effect of nitrogen plasma composition on structural-phase and elemental composition, topography, mechanical and hydrophobic properties of coatings on the basis of nitrogen-containing titanium oxide during penetration onto sample in open atmosphere is studied. It has been shown that at an equally high microhardness of the order of 25-27 GPa, by controlling the composition of the nitrogen plasma, either hydrophilic (contact angle 73 °) or hydrophobic coatings (contact angle 120 °) can be formed.
Распределение температуры на оси камеры расширения при различных схемах работы вихревой трубы
Authors: Самохвалов В.Н.
Published: July 2021

The change in air temperature along the axis of the expansion chamber in the zones of the nozzle inlet and the flow swirler in the direct-flow, counter-flow, three-flow and single-flow vortex tubes has been investigated. It has been established that in all cases, the cooling of air in the vortex tube occurs in the zone of the swirling device, and its heating - in the zone of unwinding of the flow. The change in air temperature in the axial zone along the length of the expansion chamber occurs due to heat exchange between the heating and cooling zones.
Гетероструктурные AgCl/BN-наноматериалы с высокой сорбционной способностью и фотокаталитической активностью
Authors: Конопацкий А.С. , Попова Д.В. , Калинина В.В. , Лейбо Д.В. , Матвеев А.Т. , Штанский Д.В.
Published: July 2021

In this work, the photocatalytic activity and sorption capacity of heterogeneous structures AgCl/h-BN obtained by the polyol method were studied in comparison with the initial micron-sized h-BN powder. The chemical and phase composition, as well as the surface microstructure, were analyzed by scanning electron microscopy, energy dispersive spectroscopy, X-ray phase analysis, and X-ray photoelectron spectroscopy. High photocatalytic activity and sorption ability of heterogeneous structures AgCl/BN in the reaction of the organic dye methylene blue decomposition under ultraviolet irradiation were demonstrated.
Remesas familiares y el COVID-19: eficiencia en los pronósticos para reducir la especulación en la región centroamericana
Authors: Asturias Schaub Luis Rodrigo , Díaz Lara Juan Fernando
Published: July 2021

La presente investigación aplica un método de pronóstico adecuado a los flujos de remesas que se vieron afectados por el efecto de la crisis generada por el COVID-19 en la región centroamericana, con la intención de que sirva además como un método de referencia para priorizar criterios de eficiencia en las proyecciones de estos flujos de remesas y contribuir de esta forma a reducir laincertidumbre de las autoridades monetarias, de los inversionistas y de los agentes económicos para facilitar el proceso de toma de decisiones.Al aplicar el modelo de pronóstico sugerido para cada país de la región, se obtuvo un margen de error mínimo, tanto en el valor absoluto en unidades monetarias como en términos relativos, en función de los porcentajes de la diferencia entre la estimación y el valor real que en promedio ascendió a 8.4% y menos de una desviación estándar.Adicionalmente, se pretende evidenciar que junto con otras variables macroeconómicas comprometidas ante la situación del COVID-19, las remesas siguen siendo un flujo de ingresos resiliente.
MEASURES TO SUPPORT SMALL AND MEDIUM-SIZED ENTERPRISES IN RUSSIA DURING THE PANDEMIC
Authors:   Voronezh State Technical University, Narolina T.S. , Samogorodskaya M.I. ,   Voronezh State Technical University, Bejnar I. A. ,   Voronezh State Technical University, Smotrova T. I. ,   Voronezh State Technical University
Published: July 2021

Subject. Analysis of foreign and regional practice of supporting small and medium-sized businesses in the context of restrictions caused by the coronavirus pandemic, and the dynamics of the activity of small and medium-sized enterprises. Topic. Study the growth rates of small and medium-sized enterprises in several regions and assess the impact on them of the consequences of the pandemic. Purpose. Assessment of the activity of small and medium-sized enterprises during the period of introduction of restrictions caused by the pandemic and identification of the most popular practices for supporting entrepreneurship, the impact of government support measures on them. Methodology. Methods of statistical analysis of time series of dynamics of basic indicators. Methods of logical and comparative analysis of the support measures provided abroad and in the regions of Russia, including the Voronezh region. Results. Based on the analysis and assessment of the current situation, it was revealed that there is a downward trend among small and medium-sized businesses. This is due, among other things, to the consequences of the pandemic and the restrictions imposed in 2020. State support for small and medium-sized businesses included organizational and financial measures that could be taken advantage of by business entities from the affected industries, subject to certain conditions. Application area. The sphere of regulation of small and medium-sized businesses at the meso-level. Conclusions. The economic challenges that small and medium-sized businesses had to face dictated new business conditions. Government support has allowed many companies to stay on the market during a difficult period. Keywords: small business, small and medium-sized enterprises, entrepreneurship, government support, support measures, pandemic
CIVIL LAW REGULATION OF BANKRUPTCY (INSOLVENCY) OF A LEGAL ENTITY: CURRENT STATE OF RESEARCH
Authors:   South-Western State University, Maksimova  O.A.
Published: July 2021

Subject. Problems of civil law regulation of bankruptcy of a legal entity in the conditions of market management in the Russian Federation. Topic. Civil law regulation of bankruptcy (insolvency of a legal entity: a modern research context. Goals. Identification of the state of research on the problem of legal regulation of the bankruptcy procedure of a legal entity in modern Russian civil law science. Methodology. The research uses general scientific methods of information analysis and synthesis, as well as the civil law method. Results. The main thematic areas of civil law research on the problem of legal regulation of bankruptcy of legal entities are identified and the results of comparative studies in the context of the regulation of their insolvency are evaluated. Scope of application. Scope of civil law regulation of bankruptcy (insolvency) of legal entities. Conclusions. The analysis of the degree of development of the problem of insolvency (bankruptcy) of legal entities in civil law science has shown the lack of systematic research. It can be stated that the contribution of civil law to the solution of the current problems of insolvency (bankruptcy) of legal entities in the last few years is scanty. Keywords: civil law, legal regulation, insolvency (bankruptcy), legal entities
REGIONAL BANKING SYSTEM STABILITY ASSESSMENT METHODOLOGY
Authors:   South-Western State University, Sitnikova  E.V. , Kulikov  R.R. ,   South-Western state University
Published: July 2021

Subject. Economic relations arising in the process of functioning and development of regional banking systems. Topic. Methodology for assessing the stability of the regional banking system. Purpose. The purpose of the work is to develop recommendations to improve the sustainable development of the banking system in the region. Methodology. The study was carried out using abstract-logical, comparative, economic and statistical approaches, a graphical technique for visualizing statistical and calculated data. Results. The author’s methodology for assessing the level of stability of the regional banking system is proposed, which includes three groups of indicators: indicators of institutional development, indicators of financial development, indicators of systematic functioning, which allows diagnosing the peculiarities of the development of the banking system in the territorial context. This technique has been tested, and a set of measures has been developed to increase the level of stability and reliability of regional banks. Application area. The research results, main provisions, conclusions, recommendations can be used by all commercial banks, regardless of the organizational and legal form and policy of conducting banking business. Conclusions. Currently, in the context of the spread of coronavirus infection in the country, it is important to assess the stability of the banking system, especially in the territorial context. The COVID-19 pandemic has become a serious problem for the development of the world’s economy, which also negatively affected banking activities. Thus, in a pandemic, the stability and sustainability of the banking system as a whole and in the regions is of great importance for maintaining the efficiency of the entire economic system. Consequently, the need for a comprehensive study of the level of stability of the regional banking system is determined by objective modern conditions. Keywords: banking system, efficiency, competitiveness, region, stability, reliability, regional banking system.
Rancang Bangun Sistem Navigasi Robot Hexapod 3 DOF di Ruangan Labirin Menggunakan Metode Fuzzy Sugeno Berbasis Arduino
Authors: Sidiq Ilham Muhammad , Ihsanto Eko , Yuliza Yuliza
Published: July 2021

Pada era teknologi dan otomasi industri saat ini banyak digunakan robot sebagai alat bantu yang dapat meringankan pekerjaan manusia, sehingga dibutuhkan robot yang memiliki sistem pengendalian yang baik agar pekerjaan yang dilakukan oleh robot tersebut dapat lebih optimal. Perkembangan sistem pengendalian pada robot saat ini cukup pesat seiring dengan kebutuhan manusia yang semakin beragam.Beberapa metode banyak diterapkan pada sistem pengendalian robot secara otomatis. Logika fuzzy merupakan metode yang banyak digunakan dalam navigasi gerak robot. Sehingga pada penelitian ini akan diterapkan metode logika fuzzy dengan tipe Sugeno sebagai sistem navigasi robot hexapod yang ditanamkan pada mikrokontroler Arduino mega dan digunakan lima buah sensor ultrasonik sebagai nilai inputan jarak, dan menggunakan servo motor controller 32 channel yang digunakan untuk mengontrol 18 servo untuk mengerakan robot baik maju, belok kanan, dan kiri dan juga membantu meringkas kabel yang terhubung kearduino, codingan motor servo yang mudah yang dimana hanya memanggil perintah serial ke arduino mega.Dalam hal ini logika fuzzy diterapkan untuk mengatur delay yang bisa mengatur speed robot hexapod ini ketika berhadapan  tembok dekat maka berjalan lambat dan jauh dari tembok maka berjalan cepat. Sehingga dapat menghindari halangan yang berada dengan baik.