bluuebunny/crossref_metadata_2025 huggingface dataset:
Extension of PERMANOVA to Testing the Mediation Effect of the Microbiome
Authors: Yue Ye , Hu Yi-Juan
Published: May 2022

Recently, we have seen a growing volume of evidence linking the microbiome and human diseases or clinical outcomes, as well as evidence linking the microbiome and environmental exposures. Now comes the time to assess whether the microbiome mediates the effects of exposures on the outcomes, which will enable researchers to develop interventions to modulate outcomes by modifying microbiome compositions. Use of distance matrices is a popular approach to analyzing complex microbiome data that are high-dimensional, sparse, and compositional. However, the existing distance-based methods for mediation analysis of microbiome data, MedTest and MODIMA, only work well in limited scenarios. PERMANOVA is currently the most commonly used distance-based method for testing microbiome associations. Using the idea of inverse regression, here we extend PERMANOVA to test microbiome-mediation effects by including both the exposure and the outcome as covariates and basing the test on the product of their F statistics. This extension of PERMANOVA, which we call PERMANOVA-med, naturally inherits all the flexible features of PERMANOVA, e.g., allowing adjustment of confounders, accommodating continuous, binary, and multivariate exposure and outcome variables including survival outcomes, and providing an omnibus test that combines the results from analyzing multiple distance matrices. Our extensive simulations indicated that PERMANOVA-med always controlled the type I error and had compelling power over MedTest and MODIMA. Frequently, MedTest had diminished power and MODIMA had inflated type I error. Using real data on melanoma immunotherapy response, we demonstrated the wide applicability of PERMANOVA-med through 16 different mediation analyses, only 6 of which could be performed by MedTest and 4 by MODIMA.
Integrative Taxonomy within Eremias multiocellata Complex (Sauria, Lacertidae) from the Western Part of Range: Evidence from Historical DNA
Authors: Orlova Valentina F. , Solovyeva Evgeniya N. , Dunayev Evgenyi A. , Ananjeva Natalia B.
Published: May 2022

The Kokshaal racerunner, Eremias kokshaaliensis Eremchenko et Panfilov, 1999, together with other central Asian racerunner species, is included in the Eremias multiocellata complex. In the present work, for the first time, the results of the analysis of historical mitochondrial DNA (barcode) are presented and the taxonomic status and preliminary phylogenetic relationships within the complex are specified. We present, for the first time, the results of the molecular analysis using historical DNA recovered from specimens of several species of this complex (paratypes of the Kokshaal racerunner and historical collections of the Kashgar racerunner E. buechneri from Kashgaria) using DNA barcoding.
The Effect of a Tele-Health Intervention Program on Home-Dwelling Persons with Dementia or MCI and on Their Primary Caregivers during the Stay-at-Home-Order Period in the COVID-19 Pandemic Outbreak: Evidence from Taiwan
Authors: Lai Yi-Ling , Chen Wen-Yi , Hsu Lin-Ying , Fu Chin-Hua
Published: May 2022

Background: The Taiwanese government implemented a stay-at-home order that restricted all community-based health promotion activities for the elderly by shutting down all community care centers from May 2021 to August 2021 to control the spread of COVID-19. Community-based dementia care centers were barely able to provide dementia care services during that period. Methods: The data used in this study were collected from a community-based dementia care center that was able to continue their dementia care services through a Tele-Health intervention program. The difference-in-differences methodology was applied to evaluate the effects of the Tele-Health intervention program on home-dwelling persons with dementia or mild cognitive impairment and on their primary caregivers during the COVID-19 pandemic. Results: The Tele-Health intervention program significantly increased the well-being of the participants and their primary caregivers, but the negative correlations between the Tele-Health intervention program and family functioning were also found to be significant. Conclusions: The significant substitution (negative) effects between the Tele-Health intervention program and family functioning raises the concern that promotion of the Tele-Health intervention program comes at the potential cost of a loss of family functioning. Policymakers should be cautious when considering the Tele-Health intervention program in response to pandemics and demographic transitions.
Loneliness and Optimism among Polish Nursing Students during the COVID-19 Pandemic: The Mediatory Role of Self-Efficacy
Authors: Kupcewicz Ewa , Rachubińska Kamila , Gaworska-Krzemińska Aleksandra , Andruszkiewicz Anna , Kuźmicz Ilona , Kozieł Dorota , Grochans Elżbieta
Published: May 2022

(1) The COVID-19 pandemic is a global epidemic crisis situation with negative health consequences. This study aimed to determine the mediatory role of self-efficacy in correlations between dispositional optimism and loneliness (both general loneliness and social and emotional loneliness) among Polish nursing students during the COVID-19 pandemic. (2) The study involved 894 students from six Polish universities. A diagnostic survey was used as the research method, and the Scale for the Measurement of Loneliness Scale (DJGLS), Life Orientation Test (LOT-R), and the Generalized Self-Efficacy Scale (GSES) were used to collect data. (3) The mean subject age was 20.73 years (SD = 1.81). More than half (51.01%) of the respondents scored high on the GSES scale, indicating an individual’s belief in the self-efficacy in coping with difficult situations and obstacles. However, 40.60% scored low on the LOT-R scale, indicating that the respondents were pessimistic. The mediation analysis revealed that self-efficacy plays a partial mediatory role in correlations between dispositional optimism and loneliness in general, social and emotional loneliness. (4) It is important to undertake loneliness prophylactic and prevention activities among nursing students and to develop personal resources, i.e., optimism and self-efficacy, to effectively offset the effects of the COVID-19 pandemic.
Increased Wellbeing following Engagement in a Group Nature-Based Programme: The Green Gym Programme Delivered by the Conservation Volunteers
Authors: Smyth Nina , Thorn Lisa , Wood Carly , Hall Dominic , Lister Craig
Published: May 2022

The wellbeing benefits of engaging in a nature-based programme, delivered by the Voluntary, Community and Social Enterprise sector, were examined in this study. Prior to attending The Conservation Volunteers’ Green Gym™, attendees (n = 892) completed demographics, health characteristics and the Warwick Edinburgh Mental Wellbeing Short-Form Scale. Attendees (n = 253, 28.4%) provided a measure on average 4.5 months later. There were significant increases in wellbeing after engaging in Green Gym, with the greatest increases in those who had the lowest starting levels of wellbeing. Wellbeing increases were sustained on average 8.5 months and 13 months later in those providing a follow up measure (n = 92, n = 40, respectively). Attendees who continued to engage in Green Gym but not provide follow up data (n = 318, 35.7%) tended to be more deprived, female and self-report a health condition. Attendees who did not continue to engage in Green Gym (n = 321, 36.0%) tended to be less deprived and younger. These findings provide evidence of the wellbeing benefits of community nature-based activities and social (‘green’) prescribing initiatives and indicate that Green Gym targets some groups most in need.
Cost Analysis for Patients with Ventilator-Associated Pneumonia in the Neonatal Intensive Care Unit
Authors: Raycheva Ralitsa , Rangelova Vanya , Kevorkyan Ani
Published: May 2022

The concept of improving the quality and safety of healthcare is well known. However, a follow-up question is often asked about whether these improvements are cost-effective. The prevalence of nosocomial infections (NIs) in the neonatal intensive care unit (NICU) is approximately 30% in developing countries. Ventilator-associated pneumonia (VAP) is the second most common NI in the NICU. Reducing the incidence of NIs can offer patients better and safer treatment and at the same time can provide cost savings for hospitals and payers. The aim of the study is to assess the direct costs of VAP in the NICU. This is a prospective study, conducted between January 2017 and June 2018 in the NICU of University Hospital “St. George” Plovdiv, Bulgaria. During this period, 107 neonates were ventilated for more than 48 h and included in the study. The costs for the hospital stay are based on the records from the Accounting Database of the setting. The differences directly attributable to VAP are presented both as an absolute value and percentage, based on the difference between the values of the analyzed variables. There are no statistically significant differences between patients with and without VAP in terms of age, sex, APGAR score, time of admission after birth and survival. We confirmed differences between the median birth weight (U = 924, p = 0.045) and average gestational age (t = 2.14, p = 0.035) of the patients in the two study groups. The median length of stay (patient-days) for patients with VAP is 32 days, compared to 18 days for non-VAP patients (U = 1752, p < 0.001). The attributive hospital stay due to VAP is 14 days. The median hospital costs for patients with VAP are estimated at €3675.77, compared to the lower expenses of €2327.78 for non-VAP patients (U = 1791.5, p < 0.001). The median cost for antibiotic therapy for patients with VAP is €432.79, compared to €351.61 for patients without VAP (U = 1556, p = 0.024). Our analysis confirms the results of other studies that the increased length of hospital stays due to VAP results in an increase in hospital costs. VAP is particularly associated with prematurity, low birth weight and prolonged mechanical ventilation.
Is Telemedicine in Primary Care a Good Option for Polish Patients with Visual Impairments Outside of a Pandemic?
Authors: Binder-Olibrowska Katarzyna Weronika , Wrzesińska Magdalena Agnieszka , Godycki-Ćwirko Maciek
Published: May 2022

With the proliferation of telemedicine during the COVID-19 pandemic, attention began to turn to the risk of health disparities associated with its use among people with disabilities. Therefore, the present study investigates the level of interest in using teleconsultations (TCs) in primary healthcare among people with visual impairments (PVIs) and identifies their motivations and needs. A total of 219 Polish PVIs were surveyed using a combination of closed and open questions. About 50% of the respondents expressed interest in using TCs. The factor most closely related to the willingness to use TCs was age. The predominant reason for using TCs was to obtain a prescription or referral, and the most highlighted need was the possibility to choose between a TC and an in-person visit. The blind and poor-sighted participants differed in some regards. Our study indicates that TCs, under some conditions, may be a beneficial option for PVIs, and provides some directions for its effective implementation.
Stigmatizing Attitudes toward People Living with HIV among Young Women Migrant Workers in Vietnam
Authors: Ha Toan , Givens David , Nguyen Trang , Nguyen Nam
Published: May 2022

Despite intensive HIV education and prevention efforts in the past few years, stigmatizing attitudes toward people living with HIV (PLWH) remain a major barrier to HIV prevention and treatment efforts in Vietnam. The purpose of this study was to examine the prevalence of stigmatizing attitudes regarding HIV and identify correlative factors that impact the perceptions of PLWH among a heretofore overlooked demographic in Vietnamese society: women who are migrant workers in designated industrial zones (IZs). A cross-sectional study was conducted among 1061 women migrant workers aged 18 to 29 from January 2020 to November 2020 in Hanoi, Vietnam. Stigmatizing attitudes toward PLWH were measured using a four-item scale. Multiple logistic regression was conducted to examine the factors associated with stigmatizing attitudes. Our findings indicate both substantial levels of stigma persisting among this demographic group as well as the influence of important mitigating factors on the expression of HIV-related stigma. Over seventy-six percent (76.2%) of the participants reported having at least one of the four stigmatizing attitudes. Greater levels of stigmatizing attitudes toward PLWH were significantly associated with lower HIV knowledge, lower levels of education, and identifying as Kinh (the ethnic majority in Vietnam). Additionally, this study found that questions framing HIV infection through a familial lens were significantly associated with lower rates of stigmatizing responses. The high overall levels of stigmatizing attitudes toward PLWH among the study participants suggests that there is an urgent need for the development of culturally appropriate interventions and outreach education activities to reduce stigmatizing attitudes toward PLWH among women who are migrant workers working in the IZs in Vietnam. This study adds to both the existing literature and current efforts and policies around HIV in Vietnam by empirically suggesting that familial-based messaging may be a powerful potential narrative for interventions addressing HIV-related issues such as stigma.
Antecedents and Consequences of Green Mindfulness: A Conceptual Model
Authors: Ho Yi-Hui , Wang Cheng-Kun , Lin Chieh-Yu
Published: May 2022

While many companies take the environmental environment as a fundamental part of their business strategies, managers are facing the challenges to explore the integration of environmental concepts and business operations. Although there are an amount of studies about environmental management in the literature, only a few of them applied the concept of mindfulness to environmental management. Mindfulness is regarded as a way of operation marked by the willingness to consider alternative perspectives, focus on the present, attention to operational detail, and interest in exploring and understanding failures. This study suggests that companies require keeping mindfulness in environmental management implementation. Therefore, this paper aims to explore the application of mindfulness theory to environmental management, and propose a conceptual model of antecedents and consequences of green mindfulness. The proposed multilevel model describes the influences of organizational and individual antecedents on green mindfulness, and the organizational and individual consequences of green mindfulness.
Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance Running Race
Authors: Jouffroy Romain , Anglicheau Dany , Mansencal Nicolas , Toussaint Jean François , Antero Juliana
Published: May 2022

Background: IL-6 plasma concentration (IL-6PC) reflects the systemic inflammation related to exercise intensity level. This study aims to describe the IL-6PC kinetics during a long-distance running race. IL-6PC was measured in 20 male runners before (0 km), at each refreshment point (at 21 and 53 km, i.e., k21 and k53, respectively) and at the end of an 80 km long-distance run (k80). Methods: IL-6PC variations (absolute and relative values in each of the three sections (S)) were calculated over S1 (0_k21), S2 (k21_k53) and S3 (k53_k80) and compared with the exercise intensity (duration*race speed) within each section. Results: The mean IL-6PC increased during the run: 2.1 ± 0.6 ng.L−1 at 0 km, 21.0 ± 11.3 ng.L−1 at k21, 38.9 ± 13.0 ng.L−1 at k53 and 49.8 ± 11.9 ng.L−1 at k80. Exercise intensity increased between S1 (24.2 ± 0.5) and S2 (51.9 ± 3.2) (p = 0.04) but not between S2 and S3 (67.4 ± 4.5) (p = 0.69). IL-6PC variation was associated with exercise intensity within S1 (p = 0.03) and S2 (p = 2 × 10−3) and showed at least a trend within S3 (p = 0.06). Conclusions: IL-6PC increases that occur during the early stages of a long-distance run are associated with the running intensity, and then IL-6PC remain stable after the reduction in intensity related to the decrease in running speed.
The Fear of COVID-19: Gender Differences among Italian Health Volunteers
Authors: Burrai Jessica , Quaglieri Alessandro , Aitella Umberto , Cricenti Clarissa , D’Alessio Ivan , Pizzo Alessandra , Lausi Giulia , Giannini Anna Maria , Mari Emanuela
Published: May 2022

Background: During the COVID-19 pandemic, the fear of being infected was a major concern, resulting in both physical and psychological effects. Despite several studies on fear of COVID-19 in the general population, the effects on healthy volunteers who face COVID-19 on the frontlines have not yet been investigated. Methods: An online survey on specific psychological variables related to COVID-19 was administered to 720 healthy volunteers, and gender differences were investigated. Results: The primary finding was that females showed higher scores in all dimensions assessed. A multiple linear regression conducted on both genders exhibited a similar pattern of predictors, highlighting the pivotal role of negative affect in the male group. Conclusions: The findings suggest that COVID-19 had significant effects on healthy volunteers, especially in the female group. Although the previous literature did not report the crucial role played by the negative affect in the male sample, these results highlight the need to deepen how both genders use different emotional strategies to cope with stressful situations. This study may be useful in the development of specific psychological support and ad hoc training for healthy volunteers.
The Potential of N-Acetylcysteine for Treatment of Trichotillomania, Excoriation Disorder, Onychophagia, and Onychotillomania: An Updated Literature Review
Authors: Lee Debra K. , Lipner Shari R.
Published: May 2022

Background: Trichotillomania (TTM), excoriation disorder, onychophagia, and onychotillomania are categorized as body focused repetitive behavior (BFRB) disorders, causing damage to the skin, hair, and/or nails with clinically significant psychosocial consequences. Currently, there are no standardized treatments for these compulsive, self-induced disorders. Studies on treatment of these disorders using psychotropic drugs (i.e., selective serotonin reuptake inhibitors, tricyclic antidepressants, anticonvulsants) have shown variable efficacy. Recently, there is a growing interest in N-acetylcysteine (NAC) for treating BFRBs. NAC is a glutamate modulator that has shown promise in successfully reducing the compulsive behaviors in BFRB disorders. This article provides an updated review of the literature on the use of NAC in TTM, excoriation disorder, onychophagia, and onychotillomania. Methods: Relevant articles were searched in the PubMed/MEDLINE database. Results: Twenty-four clinical trials, retrospective cohort studies, and case reports assessing the efficacy of NAC in TTM, excoriation disorder, and onychophagia were included. No studies for onychotillomania were found in our search. Conclusions: Although NAC has proven successful for treatment of BFRB disorders, data is derived from few clinical trials and case reports assessing small numbers of patients. Larger studies with longer durations are needed to fully establish the efficacy of NAC in these disorders.
In the Seeking of Association between Air Pollutant and COVID-19 Confirmed Cases Using Deep Learning
Authors: Tsan Yu-Tse , Kristiani Endah , Liu Po-Yu , Chu Wei-Min , Yang Chao-Tung
Published: May 2022

The COVID-19 pandemic raises awareness of how the fatal spreading of infectious disease impacts economic, political, and cultural sectors, which causes social implications. Across the world, strategies aimed at quickly recognizing risk factors have also helped shape public health guidelines and direct resources; however, they are challenging to analyze and predict since those events still happen. This paper intends to invesitgate the association between air pollutants and COVID-19 confirmed cases using Deep Learning. We used Delhi, India, for daily confirmed cases and air pollutant data for the dataset. We used LSTM deep learning for training the combination of COVID-19 Confirmed Case and AQI parameters over the four different lag times of 1, 3, 7, and 14 days. The finding indicates that CO is the most excellent model compared with the others, having on average, 13 RMSE values. This was followed by pressure at 15, PM2.5 at 20, NO2 at 20, and O3 at 22 error rates.
Association of Rural Hospital Admissions with Access, Treatment, and Mortality for Patients with Acute Myocardial Infarction in Shanxi, China
Authors: Tao Ding , Sun Ya
Published: May 2022

China recently launched healthcare reforms to reduce disparities in healthcare resources between urban and rural areas. However, few studies have determined how admission to rural hospitals has affected patient care and outcomes. This study aims to determine whether admission to a rural hospital is associated with changes in treatment and outcomes. Using a province-wide, administrative database of 62,380 patients (51,355 urban patients vs. 11,025 rural patients) with acute myocardial infarction (AMI) in Shanxi from 2015 to 2017, we identified the differential distance from the patient’s residential address to the nearest hospital and the nearest percutaneous coronary intervention (PCI)-capable hospital as instrumental variables. We estimated the risk-adjusted differences in outcomes and treatments for patients admitted to rural hospitals versus urban hospitals using a two-stage least squares instrumental variable analysis method. Based on instrumental variable analysis, admission to a rural hospital was associated with a 5.3% (95% CI, 0.012 to 0.093; p = 0.011) increase in mortality. There was a 59.8% (95% CI, −0.733 to −0.463; p-values < 0.0001) decrease in receiving PCI, an 18.8% (95% CI, −0.231 to −0.146; p-values < 0.0001) decrease in receiving fibrinolysis, and a 71.8% (95% CI, 0.586 to 0.849; p-values < 0.0001) increase in receiving medication-only treatment for patients admitted to rural hospitals. Rural hospitals in China thus offer relatively poor care for myocardial infarction. Hospital facilities and reperfusion therapies must be improved.
Association between Frequency of Conversations and Suicidal Ideation among Medical Students during COVID-19 Pandemic in Japan
Authors: Yamazaki Juri , Kizuki Masashi , Fujiwara Takeo
Published: May 2022

To mitigate the spread of COVID-19, universities in Japan shifted from face-to-face to online classes, which might have reduced social interaction and increased psychiatric problems among students. A self-report questionnaire was administered to fourth-year medical students in Tokyo in May 2021, during the fourth wave of the COVID-19 outbreak, to examine the association between the frequency of conversations and suicidal thoughts. The questionnaire assessed the frequency of conversations and, using part of the Mini International Neuropsychiatric Interview, suicidal ideation. Of the 113 students, 98 (86.7%) responded, of whom 20 (20.4%) had suicidal ideation. Poisson regression analysis revealed that those with less than 1 conversation per week and no conversations at all had a significantly higher risk of suicidal ideation than those with 3 conversations per week or more, after adjusting for personality, family relationship, income level, living alone, number of friends, gender, and age. These results indicate that less frequent conversations increased the risk of suicidal ideation among medical students. Mental health support for students needs to be strengthened if universities suspend face-to-face classes during a pandemic.
Projecting Informal Care Demand among Older Koreans between 2020 and 2067
Authors: Hu Bo , Shin Peter , Han Eun-jeong , Rhee YongJoo
Published: May 2022

Background: The number of Korean older people receiving informal care is expected to rise sharply due to aging population. This study makes projections of demand for informal care in community-dwelling older people aged 65 and over in Korea until 2067. Method: The study drew on data collected from waves 4–6 of the Korean Longitudinal Study of Aging (2012–2016, n = 12,975). Population data published by Statistics Korea and data from the Long-term Care Insurance Statistical Yearbook for Korea were also used. A macro-simulation model was built to make the projections. Results: The number of older people receiving informal care will increase from 0.71 million in 2020 to 2.2 million in 2067. Demand for informal care from adult children or relatives is projected to rise by 257%, much faster than the increase in demand for spousal care (164%). The estimates are sensitive to alternative assumptions about future mortality rates, fertility rates, patterns of migration, and the prevalence of functional disabilities in the population. Conclusion: Demand for informal care in Korea will rise substantially in the coming decades, and the increase will be uneven for different groups of care users. Our analyses are not only relevant to the long-term care system for the general older population but also have profound implications for intensive users of long-term care in Korea. The findings highlight the importance of accurate identification of unmet needs in the population and timely delivery of government support to older people and their informal caregivers.
Rural–Urban Differences in Non-Local Primary Care Utilization among People with Osteoarthritis: The Role of Area-Level Factors
Authors: Liu Xiaoxiao , Seidel Judy E. , McDonald Terrence , Waters Nigel , Patel Alka B. , Shahid Rizwan , Bertazzon Stefania , Marshall Deborah A.
Published: May 2022

The utilization of non-local primary care physicians (PCP) is a key primary care indicator identified by Alberta Health to support evidence-based healthcare planning. This study aims to identify area-level factors that are significantly associated with non-local PCP utilization and to examine if these associations vary between rural and urban areas. We examined rural–urban differences in the associations between non-local PCP utilization and area-level factors using multivariate linear regression and geographically weighted regression (GWR) models. Global Moran’s I and Gi* hot spot analyses were applied to identify spatial autocorrelation and hot spots/cold spots of non-local PCP utilization. We observed significant rural–urban differences in the non-local PCP utilization. Both GWR and multivariate linear regression model identified two significant factors (median travel time and percentage of low-income families) with non-local PCP utilization in both rural and urban areas. Discontinuity of care was significantly associated with non-local PCP in the southwest, while the percentage of people having university degree was significant in the north of Alberta. This research will help identify gaps in the utilization of local primary care and provide evidence for health care planning by targeting policies at associated factors to reduce gaps in OA primary care provision.
Food Desert Status of Family Child Care Homes: Relationship to Young Children’s Food Quality
Authors: Francis Lucine , Perrin Nancy , Curriero Frank C. , Black Maureen M. , Allen Jerilyn K.
Published: May 2022

Family child care homes (FCCHs) are a favored child care choice for parents of young children in the U.S. Most FCCH providers purchase and prepare foods for the children in their care. Although FCCH providers can receive monetary support from the Child and Adult Care Food Program (CACFP), a federal subsidy program, to purchase nutritious foods, little is known about FCCH providers’ access to nutritious foods, especially among FCCH providers serving children from communities that have been historically disinvested and predominantly Black. This study aims to describe the food desert status of FCCHs in Baltimore City, Maryland, and examine the relationship between food desert status and the quality of foods and beverages purchased and provided to children. A proportionate stratified random sample of 91 FCCH providers by CACFP participation status consented. Geographic information system mapping (GIS) was used to determine the food desert status of each participating FCCH. Participants reported on their access to food and beverages through telephone-based surveys. Nearly three-quarters (66/91) of FCCHs were located in a food desert. FCCH providers working and living in a food desert had lower mean sum scores M (SD) for the quality of beverages provided than FCCH providers outside a food desert (2.53 ± 0.81 vs. 2.92 ± 0.70, p = 0.036, respectively). Although the significant difference in scores for beverages provided is small, FCCH providers working in food deserts may need support in providing healthy beverages to the children in their care. More research is needed to understand food purchases among FCCH providers working in neighborhoods situated in food deserts.
Environmental Impact of Feeding with Infant Formula in Comparison with Breastfeeding
Authors: Andresen Ellen Cecilie , Hjelkrem Anne-Grete Roer , Bakken Anne Kjersti , Andersen Lene Frost
Published: May 2022

Young children have unique nutritional requirements, and breastfeeding is the best option to support healthy growth and development. Concerns have been raised around the increasing use of milk-based infant formulas in replacement of breastfeeding, in regards to health, social, economic and environmental factors. However, literature on the environmental impact of infant formula feeding and breastfeeding is scarce. In this study we estimated the environmental impact of four months exclusive feeding with infant formula compared to four months exclusive breastfeeding in a Norwegian setting. We used life-cycle assessment (LCA) methodology, including the impact categories global warming potential, terrestrial acidification, marine and freshwater eutrophication, and land use. We found that the environmental impact of four months exclusive feeding with infant formula was 35–72% higher than that of four months exclusive breastfeeding, depending on the impact category. For infant formula, cow milk was the main contributor to total score for all impact categories. The environmental impact of breastfeeding was dependant on the composition of the lactating mother’s diet. In conclusion, we found that breastfeeding has a lower environmental impact than feeding with infant formula. A limitation of the study is the use of secondary LCA data for raw ingredients and processes.
Association between Body Mass Index with Sugar-Sweetened and Dairy Beverages Consumption in Children from the Mexico–USA Border
Authors: Gómez-Miranda Luis Mario , Briones-Villalba Ricardo Ángel , Ortiz-Ortiz Melinna , Aburto-Corona Jorge Alberto , Bonilla Diego A. , Pozos-Parra Pilar , Espinoza-Gutiérrez Roberto , Calleja-Núñez Juan José , Moncada-Jiménez José , Hernández-Lepe Marco Antonio
Published: May 2022

The consumption of sugar-sweetened beverages has been associated with the onset of cardiometabolic diseases. The aim of this study was to describe consumption patterns of sugar-sweetened and dairy beverages and to evaluate their correlation with the body mass index in children residing at the Mexico–USA border. A total of 722 (370 girls, 352 boys) elementary school children aged 9 to 12 years from Tijuana, Mexico, participated in the study. Anthropometric measures were recorded, and a beverage intake questionnaire was completed by the children’s parents. Significant age by sex interactions were found on body mass index Z-scores (p < 0.01). Boys showed higher sugar intake (p < 0.05) and total relative energy consumption from sugar (p < 0.05) than girls. The energy consumption from sugar-sweetened and dairy beverages was similar between sexes (p > 0.05). Sugar intake from beverages was higher than the limit recommended by the World Health Organization in boys (66%) and girls (44%). A high frequency of consumption of sugar-sweetened beverages and similar intake of dairy beverages were found in children from the Mexico–USA border. The high consumption of sugar exceeds international recommendations and should be carefully monitored.
How Seasonality and Control Measures Jointly Determine the Multistage Waves of the COVID-19 Epidemic: A Modelling Study and Implications
Authors: Zheng Yangcheng , Wang Yunpeng
Published: May 2022

The current novel Coronavirus Disease 2019 (COVID-19) is a multistage epidemic consisting of multiple rounds of alternating outbreak and containment periods that cannot be modeled with a conventional single-stage Suspected-Exposed-Infectious-Removed (SEIR) model. Seasonality and control measures could be the two most important driving factors of the multistage epidemic. Our goal is to formulate and incorporate the influences of seasonality and control measures into an epidemic model and interpret how these two factors interact to shape the multistage epidemic curves. New confirmed cases will be collected daily from seven Northern Hemisphere countries and five Southern Hemisphere countries from March 2020 to March 2021 to fit and validate the modified model. Results show that COVID-19 is a seasonal epidemic and that epidemic curves can be clearly distinguished in the two hemispheres. Different levels of control measures between different countries during different seasonal periods have different influences on epidemic transmission. Seasonality alone cannot cause the baseline reproduction number R0 to fall below one and control measures must be taken. A superposition of a high level of seasonality and a low level of control measures can lead to a dramatically rapid increase in reported cases.
Can Stimulus Valence Modulate Task-Switching Ability? A Pilot Study on Primary School Children
Authors: D’Aurizio Giulia , Tempesta Daniela , Saporito Gennaro , Pistoia Francesca , Socci Valentina , Mandolesi Laura , Curcio Giuseppe
Published: May 2022

Executive functions and emotional processes follow a time-dependent development that reflects the brain’s anatomo-functional maturation. Though the assessment of these cognitive functions is largely examined, in children the role of emotions in the mental set-shifting is still rarely investigated. The aim of this study was to assess how attention shifting can be modulated by the valence of emotional stimuli. To this end, sixty-two primary school children were tested with a new emotional task-switching paradigm obtained by manipulating the emotional valence and physical features of the stimulus pool. Thus, two tasks were alternatively presented: the Valence task and the Color task. Based on executive performance results, we found a lengthening of response times and a lower accuracy in the emotionally connoted task (Valence task), compared to the neutral task (Color task). The data demonstrate that the processing of emotional stimuli modulates the task-switching performance during development. These findings could help in the implementation of teaching strategies that can promote the development of executive functions and, therefore, functionally improve the overall academic performance of children. Finally, a better understanding of the developmental trajectories of executive functions can help neuropsychologists both in the early diagnosis and treatment of potential executive alterations.
COVID-19 Worsens Chronic Lumbosacral Radicular Pain—Case Series Report
Authors: Illéš Róbert , Chochol Juraj , Džubera Andrej , Chocholová Alica , Zemková Erika
Published: May 2022

The knowledge of the COVID-19 symptomatology has increased since the beginning of the SARS-CoV-2 pandemic. The symptoms of nervous system involvement have been observed across the spectrum of COVID-19 severity. Reports describing difficulties of nerve roots are rare; the affection of brain and spinal cord by SARS-CoV-2 is of leading interest. Our aim therefore is to describe the radicular pain deterioration in the group of nine chronic lumbosacral radicular syndrome sufferers in acute COVID-19. The intensity of radicular pain was evaluated by the Visual Analogue Scale (VAS). The VAS score in acute infection increased from 5.6 ± 1.1 to 8.0 ± 1.3 (Cohen’s d = 1.99) over the course of COVID-19, indicating dramatic aggravation of pain intensity. However, the VAS score decreased spontaneously to pre-infection levels after 4 weeks of COVID-19 recovery (5.8 ± 1.1). The acute SARS-CoV-2 infection worsened the pre-existing neural root irritation symptomatology, which may be ascribed to SARS-CoV-2 radiculitis of neural roots already compressed by the previous disc herniation. These findings based on clinical observations indicate that the neurotropism of novel coronavirus infection can play an important role in the neural root irritation symptomatology deterioration in patients with chronic pre-existing lumbosacral radicular syndrome.
Sleep Disturbances in Children with Attentional Deficit Hyperactivity Disorder and Specific Learning Disorders
Authors: Saccani Maria Silvia , Ursumando Luciana , Di Vara Silvia , Lazzaro Giulia , Varuzza Cristiana , Vicari Stefano , Menghini Deny
Published: May 2022

Sleep disturbances may be a significant source of distress for children with neurodevelopmental disorders, and consequently also for their families. Crucially, sleep disturbances might be influenced by comorbidity. Attention deficit hyperactivity disorder (ADHD) and specific learning disorder (SLD) often co-occur, and consequently, investigating sleep disturbances in children with comorbidity of ADHD and SLD is essential. Our study aimed at detecting sleep difficulties in a group of 74 children with ADHD, 78 children with SLD, and 76 children with ADHD and SLD by using the Sleep Disturbances Scale for Children. The results showed that sleep difficulties emerge more clearly in children with comorbid ADHD and SLD compared to children with only ADHD or SLD. These sleep difficulties were not due to differences in ages and behavioral/emotional problems. In conclusion, evaluating sleep disturbances is important when assessing and managing children with ADHD, SLD, and particularly with the two comorbid conditions, to better understand their difficulties and develop tailored interventions.
Citizens’ Perception and Concerns on Chemical Exposures and Human Biomonitoring—Results from a Harmonized Qualitative Study in Seven European Countries
Authors: Matisāne Linda , Knudsen Lisbeth E. , Lobo Vicente Joana , Uhl Maria , Katsonouri Andromachi , van den Brand Annick D. , Berman Tamar , Dimovska Mirjana , Anastasi Eleni , Thoma Anthi , Középesy Szilvia , Gjorgjev Dragan , Borota Popovska Mirjana , den Braver-Sewradj Shalenie P. , Szigeti Tamás , Topuzovska Latkovikj Marija , Mārtiņsone Inese , Akūlova Lāsma , Paegle Linda
Published: May 2022

Exposure to different chemicals is an inevitable part of our everyday lives. Within HBM4EU, focus group discussions were conducted to gather data on citizens’ perceptions of chemical exposure and human biomonitoring. These discussions were hosted in Cyprus, Denmark, Hungary, Israel, Latvia, the Netherlands, and North Macedonia following a protocol developed in the first round of discussions. Results indicate the very high concern of European citizens regarding food safety and the environment. Focus group participants were well aware of potential uptake of chemicals through food consumption (e.g., preservatives, flavor enhancers, coloring agents, pesticides, fertilizers, metals), drinking water, or from polluted air and water. One of the positive aspects identified here, is the high interest of citizens in awareness and education on personal measures to control exposure. The promotion of personal behavioral changes requires active involvement of society (e.g., commuting habits, energy choices, waste disposal, dietary habits). Activities should focus on raising awareness of the general public, implementation of policy measures, and mainstreaming of related topics into the education system. Raising awareness of the general public may promote engagement of citizens, which in turn may empower them to put pressure on politicians to take effective actions. There is also a need for further research which might focus on the impact of country-specific situations and of the COVID-19 pandemic on the exposure of citizens to chemicals.
Energy Metabolism in Gynecological Cancers: A Scoping Review
Authors: Pagano Ana Paula , Ford Katherine L. , Porter Starr Kathryn N. , Kiss Nicole , Steed Helen , Kung Janice Y. , Elango Rajavel , Prado Carla M.
Published: May 2022

Determining energy requirements is vital for optimizing nutrition interventions in pro-catabolic conditions such as cancer. Gynecological cancer encompasses the most common malignancies in women, yet there is a paucity of research on its metabolic implications. The aim of this review was to explore the literature related to energy metabolism in gynecological cancers. We were particularly interested in exploring the prevalence of energy metabolism abnormalities, methodological approaches used to assess energy metabolism, and clinical implications of inaccurately estimating energy needs. A search strategy was conducted from inception to 27 July 2021. Studies investigating energy metabolism using accurate techniques in adults with any stage of gynecological cancer and the type of treatment were considered. Of the 874 articles screened for eligibility, five studies were included. The definition of energy metabolism abnormalities varied among studies. Considering this limitation, four of the five studies reported hypermetabolism. One of these studies found that hypermetabolism was more prevalent in ovarian compared to cervical cancer. Of the included studies, one reported normometabolism at the group level; individual-level values were not reported. One of the studies reported hypermetabolism pre- and post-treatment, but normometabolism when re-assessed two years post-treatment. No studies explored clinical implications of inaccurately estimating energy needs. Overall, commonly used equations may not accurately predict energy expenditure in gynecological cancers, which can profoundly impact nutritional assessment and intervention.
The Synergistic Effect of Biochar-Combined Activated Phosphate Rock Treatments in Typical Vegetables in Tropical Sandy Soil: Results from Nutrition Supply and the Immobilization of Toxic Metals
Authors: Zhang Zhiwei , Liu Beibei , He Zhenli , Pan Pan , Wu Lin , Lin Bigui , Li Qinfen , Zhang Xinchun , Wang Zhikang
Published: May 2022

Sandy soils in tropical areas are more vulnerable to potential toxic elements as a result of their low nutrition. The composite addition of biochar and phosphate material is considered a promising method of immobilizing toxic metals in sandy soils, but the synergistic effects of this process still need to be further explored, especially in typical tropical vegetables. In this study, a pot experiment was conducted to evaluate the agronomic and toxic metal-immobilization effects of single amendments (phosphate rock, activated phosphate rock, and biochar) and combined amendments, including biochar mixed with phosphate rock (BCPR) and biochar mixed with activated phosphate rock (BCAPR), on vegetables grown in tropical sandy soil. Among these amendments, the composite amendment BCAPR was the most effective for increasing Ca, Mg, and P uptake based on water spinach (Ipomoea aquatica L.) and pepper (Capsicum annuum L.), showing increased ratios of 22.5%, 146.0%, and 136.0%, respectively. The SEM-EDS and FTIR analysis verified that the activation process induced by humic acid resulted in the complexation and chelation of the elements P, Ca, and Mg into bioavailable forms. Furthermore, the retention of available nutrition elements was enhanced due to the strong adsorption capacity of the biochar. In terms of cadmium (Cd) and lead (Pb) passivation, the formation of insoluble mineral precipitates reduced the mobility of these metals within the BCAPR treatments, with the maximum level of extractable Cd (86.6%) and Pb (39.2%) reduction being observed in the tropical sandy soil. These results explore the use of sustainable novel cost-effective and highly efficient bi-functional mineral-based soil amendments for metal passivation and plant protection.
“We’re Home Now”: How a Rehousing Intervention Shapes the Mental Well-Being of Inuit Adults in Nunavut, Canada
Authors: Perreault Karine , Lapalme Josée , Potvin Louise , Riva Mylène
Published: May 2022

This study explores the ways in which a rehousing intervention shapes the mental well-being of Inuit adults living in Nunavut, Canada, where the prevalence of core housing need is four times the national average. More specifically, it compares the housing experiences of participants who were rehoused in a newly built public housing unit, to the experiences of participants on the public housing waitlist. The study was developed in collaboration with organizations based in Nunavut and Nunavik. Semi-structured interviews were transcribed, and a deductive-inductive thematic analysis was performed based on Gidden’s concept of ontological security, and Inuit-specific mental health conceptualization. Twenty-five Inuit adults participated (11 rehoused, 14 waitlist). Three themes were identified to describe how the subjective housing experiences of participants improved their mental well-being after rehousing: (1) refuge creation; (2) self-determination and increased control; (3) improved family dynamics and identity repair. Implicit to these themes are the contrasting housing experiences of participants on the waitlist. Construction initiatives that increase public housing stock and address gaps in the housing continuum across Inuit regions could promote well-being at a population level. However, larger socio-economic problems facing Inuit may hamper beneficial processes stemming from such interventions.
A Two-Phase, Joint-Commuting Model for Primary and Secondary Schools Considering Parking Sharing
Authors: Liu Huasheng , Zhao Yuqi , Li Jin , Li Yu , Li Xiaowen , Yang Sha
Published: May 2022

In light of the traffic congestion and traffic environment problems around schools that are caused by students commuting by car, this paper explores an efficient and feasible student commuting travel plan. Based on the ideas of “public–private cooperation” and “parking sharing”, combined with the characteristics of the family travel chain during the commuting period, a joint-commuting model of “private car and school bus” is creatively proposed. On the basis of considering the travel cost of parents and the operating cost of school bus, a two-phase commuting travel model for primary and secondary schools is proposed, and an algorithm is designed. The validity of the model is verified by an example and sensitivity analysis. The results show that the total time cost can be reduced by 23.33% when the private-car commuting mode is converted to the joint-commuting model. Among the results, we found that the driving time of a private car in the school commuting phase can be reduced by 23.36%, the dwell time can be reduced by 92.29%, and the driving time in the work and home phase can be reduced by 7.44%. Compared with the school-bus commuting mode, the school-bus time cost of joint commuting can be reduced by 54.88%. In addition, by analyzing the impact of various factors on the objective function and vehicle emissions, it can be seen that staggered commuting to school, regulating regional traffic volume, increasing parking spaces, and improving the utilization of parking spaces can effectively reduce the operating time cost of vehicles and exhaust emissions. The joint-commuting model proposed in this paper considers the balance between service level and resource consumption. While meeting the door-to-door travel needs of students, it can effectively reduce the travel costs of parents and school-bus operation costs, and it can alleviate traffic congestion around schools and reduce the impact on the environment.