bluuebunny/crossref_metadata_2025 huggingface dataset:
THE ART OF SPEAKING DIRECTLY. THE RECEPTION OF YEVHEN MALANIUK’S LEGACY IN JÓZEF ŁOBODOWSKI’S SKETCHES PUBLISHED IN “KULTURA” IN THE CONTEXT OF MODERNIZING POLISH- UKRAINIAN RELATIONS
Authors:   University of Warsaw, Warsaw, Poland, Nalewajk Żaneta
Published: December 2024

In 1949, the 15th issue of the Parisian “Kultura” published a text entitled “The Nation in the Journey of Yevhen Malaniuk” signed under the pseudonym Julian Kardosz. Its author attempted to provide a synthetic presentation of the Ukrainian emigration environment in the 1920s and 1930s. This was how the Ukrainian poet’s collaboration with the “Kultura” magazine, edited by Jerzy Giedroyc, began. This collaboration was an important testimony to the modernization processes in Polish-Ukrainian relations, and was also a very important voice in the literary and ideological dialogue of representatives of the Polish and Ukrainian intelligentsia, sentenced to exile for political reasons. The Polish writer Józef Łobodowski also understood the need to engage in such a discussion, as expressed in his texts such as the sketch “Przeciw upiorom przeszłości” [Against the Ghosts of the Past] published in “Kultura” 1952, no. 2/52–3/53, and an earlier article entitled “Serce za barykadą” [Heart behind the barricade] published in the first, March issue of “Trybuna” in 1932. Józef Łobodowski, deeply involved in the conscious building of Polish-Ukrainian relations, also translated a four-volume anthology of Ukrainian poetry and continued his conversation with Yevhen Malaniuk even after the author’s death. The aim of this sketch is to describe the reception of Yevhen Malaniuk’s writing evidenced in Józef Łobodowski’s journalistic and literary-critical texts published in the Parisian “Kultura”. This reception is the result of the contacts between these authors, which took place in the second half of the 1930s. In this article tries to indicate its key points, strategies for constructing arguments, and show its specificity as well as describe its significance in the processes of shaping the Polish-Ukrainian dialogue in the pages of the journal edited by Jerzy Giedroyc and the modernization of Polish-Ukrainian relations. In the reception of the Polish author, he was not so much a multicultural creator, but a poet of ideas and emotions focused on “awakening national conscience” and identity reflection among his compatriots.
SLAVIC WORLD IN WŁADYSŁAW SYROKOMLA’S WORKS AND TRANSLATIONS AS A SOURCE OF CREATIVE INSPIRATION
Authors:   Lesya Ukrainka Volyn National University, Sukharieva Svitlana , Vyshnevska Oksana ,   Lesya Ukrainka Volyn National University
Published: December 2024

One of the key issues in Władysław Syrokomla’s works and translations is the Slavic world presented against the background of the development of the literary era. The connections between his works and the activities of Slavophile groups were studied, and similar motifs were traced in the works of Ukrainian and Polish poets of the Romantic period. Attention was paid to the “east – west” antinomy, which is the basis of Slavophilic tendencies, with preferences for eastern borders.

The Slavic world was fully presented not only in Władysław Syrokomla’s poems, but also in his travel reports, stories, idylls, ethnographic collections, songs, historical dramas and translations. Syrokomla became famous as the translator of “Kobzar” by the Ukrainian bard Taras Shevchenko, who also belonged to the Slavophile movement and shaped his literary style based on the patterns of folk poetry.

On the one hand Syrokomla’s works are based on the theory of Polish Sarmatism as a noble culture and reflect national traditions in the form of legends, songs and folk tales. On the other hand it is a clear manifestation of “black romanticism” with proto-Slavic motifs. The main characters are peasants and peripheral petty gentry. Historical motifs encompass the period of development of Poland from the Middle Ages to the 18th century. A special place in Syrokomla’s work is occupied by the rural landscape and the motif of love for the small homeland. The writer used a narrative style similar to the language of the common people, which is why some of his poetic texts were considered folk songs. The peculiarities of the writer’s individual style served as an inspiration for many Slavic artists, who with great enthusiasm published translations of his works, imitated them and paraphrased them in various ways. Mykhailo Starytskyi holds a special place in the assimilation of Syrokomla’s poems in the history of Ukrainian literature. A key challenge for contemporary researchers of Polish literature is the return to Slavic sources in Syrokomla’s works and attempts at their retranslation or original translation due to the systematization of Slavophile materials.
The sale of medicines used for diabetes mellitus treatment in retail segment of Russian pharmaceutical market
Authors: Petrukhina I. K. , Lazarev A. M. , Ryazanova T. K. , Lebedev P. A. , Gladunova E. P. , Glembotskaya G. T.
Published: December 2024

Objective: to study the characteristics of the population consumption of medicines for the treatment of diabetes mellitus (DM), sold in the retail sector of the pharmaceutical market of the Russian Federation (RF).

Material and methods. The study analyzed data on products assortment and sales volumes for drugs used to treat DM (according to Anatomical Therapeutic Chemical (ATС) classification) trough pharmacies in all federal districts of the RF for the period 2020–2023. In particular, the following ATС groups were studied: A10A, A10B, H04AA and A16AX (thioctic acid), as well as “sibutramine + metformin” combination prescribed to correct obesity in DM patients. The results were obtained on basis of comparative, retrospective, logical, and graphical methods as well as content analysis, data grouping in accordance with ATС groups and descriptive statistics.

Results. In the retail sector of the pharmaceutical market of the RF, 54.9 million packages of antidiabetic drugs were sold for 32.4 billion rubles from 2020 to 2023. In the structure of sales in monetary terms, the share of Russian-manufactured drugs amounted to 16–17% approximately, and in physical terms, i.e. by the number of packages, it reached 37–39%. Throughout the analyzed period, the weighted average price (WAP) per 1 package of a drug for DM treatment increased from 472 to 589 rubles. Concurrently, as of year-end 2023, WAP per 1 package of an imported drug was 3 times higher than WAP of a domestic drug (784 and 259 rubles, respectively). In 2023, more than 45% of pharmacy sales in physical terms accrued to drugs of the ATC subgroup A10BA Biguanides (metformin), and about 25% to A10BB Sulfonylurea derivatives (glibenclamide, gliclazide, glimepiride, etc.). In 2023, the highest sales in monetary terms accrued to methsopamine, daphgylflozin, tytochotic acid, empagliflozin and gliclazide. In the structure of retail sales of drugs for DM treatment, fixed combinations accounted for about 15%. Despite an increase in the number of trade names of fixed combinations (from 24 in 2020 to 30 in 2023), their share in the products assortment structure remained insignificant, that did not comply with international recommendations for DM treatment.

Conclusion. Using pharmacoepidemiological monitoring tools, the features of the population consumption of drugs prescribed for DM treatment in the retail sector of the pharmaceutical market of the RF were studied in a retrospective aspect (for the period from 2020 to 2023). The contribution of ATC subgroups to the retail sales structure was established. It was revealed that the share of combined drugs was not more than 15% in the total retail sales structure that did not comply with international recommendations on DM treatment.
NATURAL PHYTOMELIORATION PROCESSES ON ROCK DUMPS OF ABANDONED COAL MINES (UKRAINE)
Authors: Popovych Vasyl , Voloshchyshyn Andriy , Lysyi Nazar , Petlovanyi Mykhailo , Shuplat Taras
Published: December 2024

Mining is accompanied by direct irreversible changes in the biosphere. Analysing the results of recent studies on the anthropogenic hazard of coal mine tailings and the peculiarities of tailings reclamation and phytoremediation on a global scale, it necessitates the investigation of the ecological state and natural phytoremediation of the Nadiya mine tailings in the Lviv-Volyn coal basin. The stages of succession processes on the rock dump surface have been determined. The phytomeliorative efficiency coefficient has been calculated for all periods of the phytomeliorative process on the rock dump surface. The total area of the studied site is 280 m2. Based on the calculations of changes in the dynamics of the phytomeliorative efficiency coefficients at different stages of the phytomeliorative process (KFM=0.155-4.485), it is expedient to conduct reclamation and phytomeliorative operations on the rock dump surface. The coal mining industry causes a significant technogenic burden on the environment, affects human health and transforms living conditions regardless of the place or country of extraction. Waste heaps are the most dangerous factors of environmental degradation. Studies of the impact of coal mine waste heaps on the human body and biota are conducted in almost all industrialised countries as well as countries where mineral mines are operated.
BENEFICIATION OF FERRUGINOUS MANGANESE ORE OF UM BOGMA LOCALITY, SINAI: COMPARISON BETWEEN CONVENTIONAL REDUCTION ROASTING TECHNIQUES AND MICROWAVE TECHNOLOGY
Authors: Moustafa Ahmed , Abdel-Khalek Nagui , Sharaf-Eldin Ahmed , Soltan Abdelmonem , Hassan El-Sayed
Published: December 2024

The increasing demand for high-grade manganese ores in various industries has led to a growing necessity to enhance the quality of lower-grade manganese ores with time. A representative manganese ore was collected from Um Bogma, Sinai, Egypt, and subjected to various characterization methods including X-ray diffraction (XRD), X-ray fluorescence (XRF) and ore microscopy. XRF analysis revealed a low Mn/Fe ratio of 2.81 (as elements), indicating a low ore grade. For suitability in Mn alloy production at the Sinai Manganese Company (SMC) plant in Abu Zenimah, southeast of Sinai, Egypt, this ratio should ideally exceed 5. Additionally, XRD and ore microscopy identified the mineralogical composition of the ore as pyrolusite, hematite, and manganite, with manganese patches embedded in a ferruginous groundmass at the textural scale. Three different reduction roasting techniques were evaluated, involving conventional heating in a furnace utilizing either CO – CO2 or charcoal as reducing agents, alongside reduction roasting with charcoal utilizing microwave technology. Following each technique, magnetic separation was employed, resulting in the production of high-grade manganese concentrates exhibiting high Mn/Fe ratios ranging from 19.8 to 27.45 and substantial Mn recovery rates ranging from 93.86% to 96.76%.
AN UPDATE TO THE GEOLOGY OF SEBUKU ISLAND, SOUTH KALIMANTAN, INDONESIA: CONSTRAINTS FROM PETROLOGICAL STUDIES
Authors: Widodo Wahyu , Permana Haryadi , Ernowo Ernowo , Swamidharma Yoseph C.A. , Pinahalan Inu , Cahyadi Andhy , Krisnanto Yudhi
Published: December 2024

Sebuku Island is located at the southeastern tip of Kalimantan Island and has geological similarities with the Bobaris-Meratus complex in distribution pattern and stratigraphic sequence. The pattern of straightness of geological structures between the two, both folds and faults, is generally directed from northeast-southwest to northwest-southeast. The previous geological research on Sebuku Island focused on the distribution of ultramafic rocks, which are speculated to contain iron, particularly from laterite soils. This research aims to determine the rock units in the study area to update the geological map of Sebuku Island, especially in the Sei Pinang and Halaban areas. The research method consists of fieldwork, laboratory analyses, and data analyses. The geological fieldwork collected 34 samples from detailed mapping on outcrops, trenching, and drilling. Geological structure observations were carried out on fresh outcrops and measured 57 structural geological elements from 6 locations. Petrographic analysis of 34 samples was carried out with the aim of determining rock type and mineralogical composition. Stereographic analysis of geological structure measurement data was used to define the general direction and type of geological structures in the investigated outcrops. The geological map is constructed on the basic topographic map in the scale 1:50,000 using Map-Info Pro v17.0.5. Based on petrographic observations and detailed field observations, especially in North Damar, from surface outcrops and drill core observations from Madang, the following results are revealed. In the geology of North Damar, in particular, and Sebuku Island, in general, the lithology can be described as an ultramafic rock unit (lherzolite, harzburgite, and dunite), pyroclastic rock unit (crystallo-lithoclastic tuff and crystalloclastic tuff), limestone unit, dike rock unit (microgabbro and diorite), sandstone unit, and alluvial deposit. Almost 60% of Sebuku Island outcrops belong to the ultramafic rock units, which are tectonically covered by crystalline lithic tuff and crystalline tuff and volcaniclastic rock units with interbedded limestone, unconformably covered by sandstone units, alluvial deposits, and swamp deposits. Microgabbro and diorite were observed from the drill core and were not exposed to the surface. Hydrothermal mineralization is indicated by quartz veins cross-cutting the pyroclastic rock group observed in drill cores. This research shows a more detailed geological description of the study area compared to previous research and regional geological map.
Ways to improve the system of prevention and treatment of environmental diseases
Authors: Prilipko Nina S. , Bobrovnitsky Igor P. , Gameeva Elena V. , Stepanova Alexandra M. , Badalov Nazim G.
Published: December 2024

International experience, as well as many Russian research works, prove the necessity to concentrate efforts of healthcare professionals and researchers on development of healthcare technologies for diagnosis, prevention and treatment (including health resort treatment and rehabilitation) of so-called environmental diseases caused by unhealthy environments and adverse environmental factors (physical, chemical, biological, social ones). This paper proposes the integration of research areas in environmental medicine into profiles of various research specialties (Occupational Medicine, Ecology, etc.). It is also proposed to transform the healthcare specialty of Doctor of Occupational Medicine into Doctor of Environmental Medicine.
Finding ways to improve the system of prevention and treatment of environmental diseases, discussing the issues of further integration of environmental medicine, public health, ecology, occupational medicine, restorative medicine and other biomedical, preventive and clinical disciplines may improve the diagnosis and treatment of human diseases caused by adverse effects of environmental factors, as well as contribute to the development of preventive strategies.
The methods of epidemiologic (including prenosologic) diagnostics based on the assessment of functional reserves of the body should play a key role in scientific research with the implementation of its results in the practice of health professionals of various profiles, including environmental occupational pathologists, in order to improve clinical diagnostics and develop personalized treatment and rehabilitation programs for patients exposed to adverse environmental factors.
CUSTOMERS' PERCEPCION AND ATTITUDES TOWARD MINIMALISM CONCEPT IN ADVERTISING
Authors:   University VERN, Plantic Tadic Diana , Ivancic Mihaela , Dawidowsky Mamic Maja
Published: December 2024

Nezaobilazno jačanje konkurencije i diferencijacije u svim oblicima marketinške komunikacije zahtijeva i od oglašivača da prihvate najučinkovitije koncepte kojima bi se istaknuli na tržištu i pridobili veću naklonost potrošača. Jedan od takvih novijih jest i minimalizam koji se danas pronalazi u širokom spektru različitih područja, uključujući umjetnost, arhitekturu, stil života, ali i marketinšku komunikaciju. Dosadašnje relevantne spoznaje ukazuju na potrebu istraživanja percepcije i stavova potrošača prema konceptu minimalizama u segmentu oglašavanja na hrvatskom tržištu. Provedenom elektroničkom anketom obuhvaćen je značajan uzorak punoljetnih potrošača, a statistička analiza ukazala je na povećanu razinu njihove pozornosti minimalističkim oglasima te njihov većinom pozitivan stav prema minimalizmu u oglašavanju. Uzimajući u obzir utvrđena ograničenja istraživanja, može se načelno zaključiti da hrvatski potrošači preferiraju primjenu minimalistički u odnosu na tradicionalan koncept u oglašavanju, što bi trebala biti korisna smjernica hrvatskim poduzećima i marketinškim agencijama za oblikovanje strategije kojom će se diferencirati u konkurentnom oglašivačkom prostoru.
MINIMUM WAGE AND MANUFACTURING LABOR SHARE: EVIDENCE FROM NORTH MACEDONIA
Authors:   University American College Skopje, North Macedonia, Petreski Marjan , Pehkonen Jaakko
Published: December 2024

The objective of the paper is to understand whether the minimum wage plays a role in the labor share in the manufacturing sector in North Macedonia. We decompose the movements of the labor share into those along a share-capital curve, shifts of this locus, and deviations from it. We use the capital-output ratio, total factor productivity and input prices to capture these factors, while the minimum wage is introduced as an element that shifts the curve. We estimate a panel of 20 manufacturing branches over the period 2012-2019 with FE, IV and system-GMM estimators. We find that the role of the minimum wage for the labor share is industry-specific. In labor-intensive and low-paid industries, it increases workers’ labor share, which corresponds to a complementarity between capital and labor. For capital-intensive branches, it reduces labor share, likely through the job loss channel and along a substitutability between labor and capital. This applies to both branches where foreign investment and heavy industry are integrated.
Passive Seismic Imaging of Urban Environments Using Distributed Acoustic Sensing: A Case Study from Melbourne, Australia
Authors: Lai Voon Hui , Miller Meghan S. , Jiang Chengxin , Yang Yan , Magrini Fabrizio , Zhan Zhongwen , McQueen Herb
Published: December 2024

Distributed acoustic sensing (DAS) offers a cost effective, nonintrusive method for high-resolution near-surface characterization in urban environments where conventional geophysical surveys are limited or nonexistent. However, passive imaging with DAS in urban settings presents challenges such as strong diurnal traffic noise, nonlinear array geometry, and poor fiber coupling to the ground. We repurposed a dark fiber in Melbourne, Australia, into a 25 km DAS array that traces busy arterial roads, tram routes, and orthogonal sections. By employing noise cross correlation and array beamforming, we calculated dispersion curves and successfully inverted for a near-surface shear-wave velocity model down to 100 meters. Stationary seismic sources are maximized by selecting daytime traffic signals, thereby recovering surface waves and reducing interference from acoustic waves from man-made structures in the subsurface. Poorly coupled channels, which are linked to fiber maintenance pits, are identified through cross-correlation amplitudes. The dispersion curve calculation further considers the channel orientation to avoid mixing Rayleigh and Love waves. Using a trans-dimensional Markov chain Monte Carlo sampling approach, we achieved effective model inversion without a prior reference model. The resulting near-surface profile aligns with mapped lithology and reveals previously undocumented lithological variation.
role of the Water Framework Directive in enhancing water use efficiency in the EU
Authors: Pérez Zabaleta Amelia , Borrat Sanjuan Monica
Published: December 2024

The increasing economic activity, population growth and urbanisation are placing increasing stress on Europe’s freshwater resources. The European Union's Water Framework Directive (WFD) aimed to establish measures to foster efficient use of this valuable natural resource while simultaneously protecting the environment. This study allows for an assessment of the Directive's application of public policies to a natural resource, assuming that the efficiency of water use is measured by water productivity. For the purposes of this investigation, purely economic variables and specific variables pertaining to the implementation of the WFD will be considered. The final econometric model indicates that variables with a positive impact, including research and development (R&D) expenditure and the governance index, necessitate the updating of facilities, the implementation of public control of the resource, and the encouragement of citizen interest in influencing EU policies. Conversely, variables with a negative impact, including population density and water consumption, indicate that as the utilization of a given resource intensifies, the efficacy of that utilization diminishes. The analysis by country indicates that the northern and more industrialised economies have more efficient water use levels. The evolution over time demonstrates that the WFD is being implemented more extensively in regions where it is most needed, resulting in increased productivity values in areas where they are currently lower.
Unlocking regional value chains: Fintech’s role in the Western Balkans' integration into global markets
Authors: Shaqiri Gentjan , Kacani Jolta , Qorraj Gazmend
Published: December 2024

Digitalization and automation are restructuring the geographical landscape of operations and labor, significantly altering operations in global value chains (GVCs). Digital technologies are expected to boost resilience, enhance transparency, and foster sustainability in GVCs. In this context,  this paper looks at how the application of fintech solutions fosters the creation of regional value chains (RVCs), increasing attractiveness and generating new opportunities for enterprises in the Western Balkan region to participate in GVCs To fill the existing gap for granular analysis at the industry level, the paper examines if enterprises in the Western Balkans that apply of fintech solutions in financial management have better opportunities to create RVCs than the ones that resist fintech implementation. Using a benchmarking instrument on fintech solutions implemented on 370 enterprises, this paper tries to identify industries with the highest potential to create RVCs and higher prospects for integration in GVCs. Our findings indicate that fintech solutions and applications can be one of the main driving forces in transforming and upgrading RVCs in Western Balkan countries.
Clinical-epidemiological characteristics of patients hospitalized for COVID-19 with chronic diseases during the first seven months of the pandemic in Paraguay, 2020
Authors: Duarte-Zoilan Derlis , Santacruz Ethel , Benítez Gilda , Sequera Guillermo , Cañete Felicia
Published: December 2024

Introduction: COVID-19, a respiratory infection caused by SARS-CoV-2, has demonstrated varying severity across populations, with approximately 20% of patients developing complications and less than 5% experiencing severe disease requiring hospitalization. The impact of chronic diseases on COVID-19 outcomes remains particularly relevant in developing countries, where healthcare resources and population characteristics differ from well-studied settings.
Objective: Describe the clinical and epidemiological characteristics of patients hospitalized with COVID-19 during the first seven months of the pandemic in Paraguay, analyzing how chronic non-communicable diseases (NCDs) influenced disease progression and outcomes.
Material and Methods: We conducted a cross-sectional analytical study examining medical records from patients hospitalized with confirmed SARS-CoV-2 infection across five major referral hospitals in Paraguay from March to September 2020. Using bivariate and multivariate logistic regression analyses with likelihood ratio criterion, we identified factors associated with ICU admission and mortality, considering p<0.05 statistically significant.
Results: Among 1,690 hospitalized patients, 797 (47.2%) met inclusion criteria, with a median age of 51 years and male predominance (53.8%). Chronic diseases were present in 61.9% of patients, with hypertension (29.6%) and diabetes (25.6%) being most prevalent. Multivariate analysis revealed that age over 80 years (OR=7.70), presence of COPD (OR=2.58), and having three or more NCDs (OR=2.78) significantly increased mortality risk. ICU admission was required for 29.6% of patients, with an overall mortality rate of 29.1%.
Conclusion: The severity of COVID-19 outcomes among hospitalized patients in Paraguay showed strong associations with advanced age, multiple chronic conditions, and specific comorbidities like COPD. These findings emphasize the need for targeted preventive strategies and enhanced monitoring of high-risk patients, particularly those with multiple NCDs.
La dudosa constitucionalidad de la actual regulación autonómica en materia de viviendas de uso turístico: Una crítica desde la perspectiva jurídico-privada
Authors: Botello Hermosa José María
Published: December 2024

En el presente artículo abordamos la eventual falta de competencia del legislador autonómico para regular las viviendas desde el punto de vista del derecho civil, identificando el instrumento jurídico que da origen a esta figura contractual y cuestionando la competencia de las comunidades autónomas para su delimitación.
Inhibition of ACC1 Diminishes the Malignant Phenotype of Hepatobiliary Cancers In Vitro
Authors: Jacquet Noel , Yu Jianhua , Shen Xinggui , Zhao Yunfeng
Published: December 2024

Hepatobiliary cancers are a collection of malignancies arising from liver and biliary tract cells. These cancers have high anatomical proximity, overlapping symptoms, and share common risk factors. Hepatobiliary cancers are generally rare and often lack effective treatment options due to late diagnoses and limited treatment efficacy. These cancers tend to be highly aggressive, which limits treatment options for patients, especially since diagnosis often occurs at later stages of disease progression. Chronic inflammation is the most significant risk factor for developing these malignancies. Inflammation alters cellular metabolism, which gives them unique metabolism characteristics that enhance their survival and increase malignancy. Acetyl-Coa-carboxylase (ACC) is a metabolic enzyme responsible for the carboxylation of acetyl-CoA (AC) into malonyl-CoA (MC). MC is used in de novo fatty acid synthesis, an upregulated process in human cancers. Acetyl-Coa-carboxylase 1 (ACC1), in particular, is the first rate-limiting step for de novo lipogenesis. Here we delve into the effect of ACC1 inhibition on the malignant phenotypes of hepatobiliary cancers. Our results showed that knockdown of ACC1 slowed proliferation and migration, reduced spheroid formation, and altered cell cycle progression and protein expression in hepatobiliary cancers. In conclusion, our study suggests that ACC1 may contribute to hepatobiliary cancers' malignancy and may be utilized as a therapeutic target for treating such diseases.
Heart failure management – A multidisciplinary approach: Literature review and single center experience
Authors: Darciuc Radu , Boiciuc Irina , Eraslan Hakan , Tașnic Mihail , Cozma Constantin , Ivanov Daniela , Voitov Sergiu , Diker Erdem , Batrînac Aureliu
Published: December 2024

Introduction: Heart failure is a severe chronic disease affecting millions of people worldwide, decreasing their quality of life and having a high burden of mortality. The treatment of the heart failure evolved in a spectacular way in the last years with the development of the new medical therapies, interventions and devices. Unfortunately, outcomes remain poor and need proper implementation of the current knowledge. A multidisciplinary team approach is considered the best way to deliver care for heart failure patients.

Objective: To make a short review of recent data provided by the trials and to describe why the multidisciplinary team approach is necessary during heart failure care. To describe how is the heart failure management performed in our center.

Literature review and our center experience: We analyzed the European Society of Cardiology Guidelines for the diagnosis and treatment of acute and chronic heart failure, made a literature search in Pubmed database and selected the most important articles related to the heart failure management, giving special attention to the evidence provided by the clinical trials.

We describe how we implemented the recommendation and multidisciplinary team approach in Medpark International Hospital, Chisinau, Republic of Moldova.

There are pharmacological management and a non-pharmacological management available. Non-pharmacological management of the heart failure includes cardiac surgery, interventional cardiology, electrophysiology, sleep-disordered breathing treatment, physical therapy, patient education, etc. Many cases of HF patients need a Heart Team approach that includes a cardiac surgeon, an interventional cardiologist, an electrophysiologist and a general cardiologist. We implemented the multidisciplinary approach providing better care for our patients.

Conclusions: The care of heart failure is multidisciplinary and needs some super-specialized team members.

A multidisciplinary team approach is considered the best way to deliver care for HF patients. There are lot of tricky situations when a decision made without the team support could be a wrong decision. To avoid such situations is important to implement the MDT approach and to continually educate the team members, keeping the pace with the HF management updates.
In Silico Characterization of Two Adjacent Novel Homozygous Nucleotide Variations in the PEX6 Gene Predict L898V Mutation to Enhance Infantile Refsum Disease and Heimler Syndrome
Authors: Madhavan Lashudaa , Nagarajan Hemavathy , Vetrivel Umashankar , Jagadeesan Madhavan
Published: December 2024

Background: Zellweger spectrum disorders are autosomal recessive in origin due to defects in peroxisome biogenesis and with variable severity. The present work aims to characterize a South Asian Indian Zellweger spectrum disorder family with PEX6 mutation for a genotype-phenotype association.

Method: The affected and unaffected individuals in the family were evaluated. A comprehensive examination of the ocular, auditory, dental, integumentary, neuronal, hepato-renal, endocrine, skeletal, cardiac, and other systems was conducted. Investigations deemed fit for diagnosis and management were done. Karyotyping and molecular genetic screening of the peripheral venous blood were performed for aneuploidy and mutation detection. Retinal fundus photograph, optical coherence tomography, bilateral audiogram, magnetic resonance imaging of the brain, ultrasonography of the abdomen, electrocardiography, and echocardiogram were performed. Any non-synonymous nucleotide variations detected were analyzed using in silico methods.

Results: The proband was born of consanguinity and had retinitis pigmentosa in both eyes, bilateral sensorineural deafness, amelogenesis imperfecta, Beau's line, and punctate leukonychia corresponding to Heimler syndrome. In addition, the proband had developmental nuclear cataracts, ichthyosis, developmental delay, cerebellar ataxia, cognitive deficit, peripheral neuropathy, and muscle movement disorder corresponding to inherited Refsum disease. The proband did not have anosmia. The brain's magnetic resonance imaging, abdomen ultrasonography, electrocardiography, and echocardiogram were normal. The karyotyping revealed euploidy status. The molecular genetic screening detected two novel adjacent homozygous non-synonymous nucleotide variations c.2691C>A (p.Ser897Arg) and c.2692C>G (p.Leu898Val) in the PEX6 gene. The pathogenic effect, structural destabilization effect, and functional impact of the variants were analyzed through in silico methods. The L898V variant was highly pathogenic compared to the non-conserved S897R variant of PEX6, leading to structural instability and loss of functionality. The molecular dynamics simulation studies also revealed the L898V variant to cause structural instability of PEX6 with higher backbone deviations and residue-wise fluctuations.

Conclusion: This study confirms the significance of L898V variant on the functionality of PEX6 that resulted in a severe disease phenotype. Genetic counseling, followed by multidisciplinary clinical evaluation was required to manage the patient with peroxisomal biogenesis disorder. A phytanic acid-restricted diet may be beneficial to control the infantile refsum disease severity.
Hyperventilation Syndrome: why is it so often overlooked?
Authors: Tavel Morton
Published: December 2024

Hyperventilation syndrome is far more common than generally believed, and thus usually unrecognized. It often produces misleading complaints that include alterations of consciousness, inexplicable sensory and motor sensations, and it is often masked by coexisting somatic symptoms. Confounding the confusion, patients are often unaware of excessive breathing, and subjective “dizziness” is often the presenting complaint, which may lead to syncopal episodes. Obscuring recognition further, symptoms attributed to the panic disorder often overlap with those of hyperventilation. Proper diagnosis of hyperventilation is described by the simple bedside maneuver of forced breathing. This diagnosis must be considered before effective management can occur.
Upfront Axillary Surgical Management: Remaining Questions
Authors: Marin Chelsea , Huston Alissa , Weiss Anna
Published: December 2024

Early breast cancer is treated with curative intent by a network of incredibly interconnected disciplines. There are certain points in each discipline’s decision-making that can affect one of the others, and one such point is axillary surgery. Because removing all the lymph nodes from the cancer-containing historically provided the most accurate lymph node information to other disciplines, standard-of-care axillary surgery had been removal of all axillary lymph nodes with an axillary lymph node dissection (ALND). The benefit of an accurate ALND was soon outweighed, though, by its plethora of associated morbidities. This sparked numerous landmark clinical trials that ultimately demonstrated the safety of ALND omission. Following these trials there has been a trend toward de-escalating axillary surgery whenever possible. This review will explore the remaining questions in upfront axillary surgical management, specifically focusing on hormone receptor-positive (HR+) breast cancer patients, and the accompanying challenges for systemic therapy administration decisions.
Digenic inheritance in patients with undiagnosed myopathies
Authors: Peddareddygari Leema , Grewal Raji
Published: December 2024

Advances in genetic sequencing have allowed a specific gene-based diagnosis in many patients with a suspected genetic myopathy. However, a significant minority of patients remain in whom the specific diagnosis remains elusive. In addition to the classic forms of Mendelian inheritance including autosomal recessive, autosomal dominant and X-linked, another mechanism of genetic transmission is digenic inheritance. This occurs when there is an interaction of two genes resulting in a given phenotype. In this study, we report three patients with myopathy hypothesized to follow a digenic pattern of inheritance. All of the patients had progressive weakness due to a myopathic disorder and underwent genetic analysis of a panel of genes established to cause inherited myopathies. Variants were observed in multiple genes in this panel. The data was further analyzed by review of published reports of the variants, public databases to determine the frequency and subjected to protein modeling to assess their possible pathogenic significance. One patient had variants in the CAPN3 (c.1553A>G; pGln518Arg) and SYNE2 (c.7664C>T; p.Thr2555Met) genes that our analysis indicates are the likely cause of her myopathy. Following a similar protocol, a second patient carries genes with two variants that are in cis in the TTN gene (c.85582G>A; p.Val28528Ile and c.103292C>T; p.Thr34431Met). There is another variant in the SYNE2 gene (c.18632C>T;p.Thr6211Met) and the combination of both likely result in her myopathy. In the last patient, a previously described mutation in the COL6A2 gene, c.1970-3 C>A in intron 25 was identified. This can result in limb girdle muscular dystrophy phenotype observed in this patient. In addition, a new variant was detected in the SGCG gene, c.643 G>T, p.Ala215Ser and its role as a modifier of disease phenotype is discussed. Our study suggests that digenic inheritance should be considered in patients with suspected undiagnosed myopathies in whom next generation sequencing fails to establish a diagnosis.
Study of Prognostic Factors in Patients with Colorectal Cancer and Central Nervous System Metastasis: A Retrospective Analysis
Authors: Arruda Daniella , Donadio Mauro , Silva Maria , Mello Celso
Published: December 2024

Background: Metastasis of colorectal cancer to the central nervous system (CNS) is relatively rare but leads to shorter survival for these patients, even with improvements in palliative treatments.

Objectives: The primary objective of this study was to assess the overall survival of patients with brain metastasis from colorectal cancer treated at the A.C. Camargo Cancer Center. The secondary objectives were to identify clinical and epidemiological factors, correlate clinicopathological factors with overall survival, and describe prognostic factors associated with CNS metastasis.

Methods: We retrospectively evaluated patients with metastatic colorectal cancer and CNS involvement treated from January 2002 to August 2020 at a single cancer center.

Results: We identified 46 patients with a median age of 63.9 years; 50% were male, and 80% had a good performance status. The predominant primary site was the left colon (71.7%). Sixty percent were stage IV, 71.7% had previously presented with lung metastasis, and 76.7% had a high volume of lung disease. RAS mutations were detected in 56.5% of the pts. Progression to the CNS occurred after a median of three treatment lines, with a median time of 49.5 months between diagnosis and progression to the CNS. Sixty percent had supratentorial lesions, and 55.6% had only one lesion. After a median follow-up time of 27.2 months, the overall survival was 6.4 months. Surgery and radiation were associated with improved overall survival (HR 0.24, 95% CI 0.09-0.67; p = 0.006; and HR 0.20, 95% CI 0.08-0.5; p = 0.001, respectively).

Conclusion: Our study found that most patients with CNS metastasis experienced progression after three lines of palliative treatment, had prior high-volume lung metastasis, and presented with left-sided tumors. Surgery and radiation may improve overall survival.
An assessment on cholesterol: A vital component for human health
Authors: Dubey Shivam
Published: December 2024

A vital chemical in humans, cholesterol can cause sickness when it is present in excess or insufficiently. Numerous articles exist that address dietary cholesterol, including the well-established link between it and the most prevalent diseases, as well as the issue of diet recommendations that are always changing. Noncompliance in the general population is the main cause of concern when it comes to cholesterol consumption. On the other hand, cholesterol is just as vital to the human body as any other nutrient. Understanding the advantages and risks of cholesterol from a scientific standpoint will improve our capacity to manage illnesses linked to this special molecule.
Role of Yoga Prana Vidya (YPV) system in the successful management of metabolic diseases: A Review
Authors: Nanduri Venkata Satyanarayana , Neravetla Jayachander Reddy
Published: December 2024

Metabolism is the complicated chemical reaction in the body's cells that changes food into energy. Nutrition and metabolism are correlated. Metabolic syndrome, a spectrum of metabolic disorders such as obesity, diabetes, cholesterol, blood pressure, etc., is a significant public health problem in India. Prevention and control of metabolic disorders is the focus of healthcare systems. This paper presents a review of recent research on how the Yoga Prana Vidya(YPV) System of Healing protocols have successfully resolved metabolic issues.

This study uses a literature review method to identify relevant research articles and synthesize the results. A total of 9 eligible research articles meeting the criteria were selected and the combined sample was 257 people. 2 papers have case studies with a sample of 3 and the remaining 7 have a sample of 254 people who improved metabolic well-being. In 4 out of the 7 studies, the sample of 207 patients experienced statistically significant improvements in body weight, BMI, and waist size within 1 to 7 days of healing camp. Results from the remaining 3 studies with a sample of 47 show marginally significant improvements.

The evidence gathered from this study validates the YPV system as a performing therapy to effectively prevent and manage metabolic disorders. Further research with appropriate samples and methodologies is recommended.
El debate sobre los modos de producción en América Latina y la crítica de Carlos Sempat Assadourian
Authors: Ibarra Antonio
Published: December 2024

El artículo explora los contornos del debate sobre los modos de producción, que caracteriza los momentos teóricos de los historiadores marxistas y su relevancia en la obra de Carlos Sempat Assadourian. Se intenta recrear el clima intelectual, a partir de un celebrado artículo en el que Assadourian pone distancia de la influyente visión de André Gunder Frank, que dispuso una discusión alrededor de la temporalidad de los modos de producción y la inminencia de la revolución socialista. Una crítica al marxismo ortodoxo que, para historiadores como Assadourian, no se resolvía en el plano puramente teórico, sino en la investigación empírica y en una correcta interpretación de la naturaleza e historicidad de las relaciones de producción en el espacio americano.
La publicación por parte de los centros de arbitraje de laudos que no hayan sido impugnados
Authors: Bustamante Luna Francisco
Published: December 2024

La publicación de los laudos arbitrales como medida de transparencia y herramienta para estudio de casos análogos, enfrenta a una corriente de defensores de la tesis de que la confidencialidad del proceso arbitral se extiende inclusive a los laudos arbitrales. Las legislaciones y centros de arbitraje, que aprecian y defienden el deseo de las partes de mantener la reserva en los asuntos materia de controversia, han actuado cautelosamente en cuanto a la posibilidad de publicidad. No han dejado de reconocer los argumentos a favor de esta y algunos centros arbitrales de prestigio han efectuado reformas a sus normas y reglamentos para regular con condicionamientos la mencionada publicidad. En general, se debe cumplir exigentes requisitos concretos para que esto ocurra. Este artículo busca dar algunos antecedentes y orientaciones, a fin de que en el Ecuador se encuentre un equilibrio en las medidas que deben tomar los centros para resolver el problema, robusteciendo el mecanismo arbitral a tono con los tiempos.
Arbitraje estatutario en Ecuador: recientes reformas legislativas con errores de bulto
Authors: Carmigniani Eduardo , Cepeda Altamirano Carla , Muriel Bedoya Bernarda
Published: December 2024

El arbitraje estatutario es un mecanismo para solventar controversias societarias entre los diferentes actores en el desenvolvimiento de una compañía como socios, accionistas, administradores, fiscalizadores, entre otros. En Ecuador, la habilitación legal y constitucional para acudir a arbitraje estatutario ha existido desde hace décadas. Sin embargo, poco o nada se ha empleado esta figura. En nuestro criterio, por falta de difusión. Desde 2019 se promovieron reformas a la Ley de Compañías incluyendo normativa relacionada con esta materia. Creemos que el ánimo del legislador era promover el arbitraje intra-societario. No obstante, los textos aprobados merecen severos reparos.
La aplicación de la política global anticorrupción en el Derecho Internacional de Inversiones
Authors: Jijón Letort Rodrigo , Bahamonde Villafuerte Macarena
Published: December 2024

Varios casos de corrupción que vinculan a compañías nacionales y extranjeras han salido a la luz en los últimos años, revelando la vulnerabilidad de las instituciones públicas. Al mismo tiempo, Ecuador ha demostrado su interés en atraer inversión extranjera a través de distintas iniciativas. Este artículo expone y sugiere la necesaria relación que debe existir entre la política nacional de atracción de inversión extranjera y la política mundial anticorrupción como un posible mecanismo que fomenta el desarrollo económico y social del país.
Prescripción y Caducidad en el Arbitraje con el sector público: una mirada a un problema inexistente
Authors: Aguilar Andrade Juan Pablo
Published: December 2024

El texto parte del debate acerca de si los plazos para plantear acciones contencioso administrativas prescriben o caducan, y la relación que este tema tiene con el arbitraje. Analiza los conceptos de prescripción y caducidad en la legislación y en la jurisprudencia ecuatorianas, para concluir que el problema es en realidad de orden semántico, y no tiene una consecuencia práctica. El tema fundamental es el que tiene relación con la aplicabilidad de las reglas sobre plazos para plantear acciones, al arbitraje en el que intervienen instituciones del sector público y, sobre todo, los casos en que a los contratos celebrados por la Administración se les debe aplicar la regla del Código Orgánico Administrativo, y aquellos en los que la norma aplicable es el Código Civil.
Cláusula de sumisión al Tribunal de Arbitraje Deportivo vía apelación en los Estatutos de la FIFA ¿Derecho adquirido para las federaciones miembro?
Authors: Barona B. Stefanny
Published: December 2024

El presente artículo expone los argumentos a favor y en contra respecto de la aplicación de la cláusula de sumisión al Tribunal de Arbitraje Deportivo contenido en los Estatutos de la FIFA, al estatuto o reglamento de las federaciones y sus miembros, y las decisiones que ha tomado el tribunal al respecto.
La sección 1782 del título 28 del código de Estados Unidos y sus implicaciones dentro del Arbitraje Internacional y de Inversiones
Authors: Gómez de la Torre Blanca , Vásconez Jácome Steven
Published: December 2024

El discovery es una herramienta utilizada para la obtención de prueba en posesión de los residentes y nacionales de los Estados Unidos de América (también “EE. UU.”). Esta era utilizada por las partes intervinientes en los foros de arbitraje para ir un poco más allá en la producción de prueba por parte de los residentes del país previamente mencionado, sin embargo, su aplicación no era clara y tenía divididos a los tribunales de circuito en los EE.UU. Esto ocasionó que la Corte Suprema de dicho país decidiera dar su interpretación de la Sección 1782 del Título 28 del Código de Estados Unidos con el fin de terminar con las interpretaciones divididas, no obstante, aún quedarían espacios para interpretación. Finalmente, se analiza el impacto que esta decisión puede tener dentro de los foros de arbitraje al no ser el único medio de producción de prueba y solo ser aplicable a la persona residente o nacional de los EE. UU.