bluuebunny/crossref_metadata_2025 huggingface dataset:
Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study
Authors: Rohmann Jessica L. , Longstreth W. T. , Cushman Mary , Fitzpatrick Annette L. , Heckbert Susan R. , Rice Kenneth , Rosendaal Frits R. , Sitlani Colleen M. , Psaty Bruce M. , Siegerink Bob
Published: November 2020

Objective

To investigate the relationship between high FVIII clotting activity (FVIII:C), MRI-defined white matter hyperintensities (WMH) and cognitive function over time.

Methods

Data from the population-based Cardiovascular Health Study (n = 5,888, aged ≥65) were used. FVIII:C was measured in blood samples taken at baseline. WMH burden was assessed on two cranial MRI scans taken roughly 5 years apart. Cognitive function was assessed annually using the Modified Mini-Mental State Examination (3MSE) and Digit Symbol Substitution Test (DSST). We used ordinal logistic regression models adjusted for demographic and cardiovascular factors in cross-sectional and longitudinal WMH analyses, and adjusted linear regression and linear mixed models in the analyses of cognitive function.

Results

After adjustment for confounding, higher levels of FVIII:C were not strongly associated with the burden of WMH on the initial MRI scan (OR>p75 = 1.20, 95% CI 0.99–1.45; N = 2,735) nor with WMH burden worsening over time (OR>p75 = 1.18, 95% CI 0.87–1.59; N = 1,527). High FVIII:C showed no strong association with cognitive scores cross-sectionally (3MSE>p75 β = -0.06, 95%CI -0.45 to 0.32, N = 4,005; DSST>p75 β = -0.69, 95%CI -1.52 to 0.13, N = 3,954) or over time (3MSE>p75 β = -0.07,95% CI -0.58 to 0.44, N = 2,764; DSST>p75 β = -0.22, 95% CI -0.97 to 0.53, N = 2,306) after confounding adjustment.

Interpretation

The results from this cohort study of older adult participants indicate no strong relationships between higher FVIII:C levels and WMH burden or cognitive function in cross-sectional and longitudinal analyses.
The CAM-ICU-7 and ICDSC as measures of delirium severity in critically ill adult patients
Authors: Krewulak Karla D. , Rosgen Brianna K. , Ely E. W. , Stelfox Henry T. , Fiest Kirsten M.
Published: November 2020

Background

In clinical practice, a dichotomous approach to delirium identification may no longer be relevant when existing delirium screening tools measure a range of scores. The objective of this study was to compare the Confusion Assessment Method for the Intensive Care Unit 7-item (CAM-ICU-7) and the Intensive Care Delirium Screening Checklist (ICDSC) as measures of the spectrum of delirium severity in critically ill adult patients.

Methods

In this cross-sectional study, 218 patients underwent 641 paired assessments by bedside nurses (ICDSC, as per usual care) and trained research assistants (CAM-ICU-7). Correlation between the CAM-ICU-7 and ICDSC scores was evaluated. Logistic regression was used to explore associations between CAM-ICU-7 or ICDSC score and length of ICU stay and mechanical ventilation (receipt, ≥96 hours).

Results

Delirium prevalence evaluated by the CAM-ICU-7 and ICDSC were 46.3% (95% CI:39.7–53.0) and 34.4% (95% CI:28.3–41.0). Prevalence of less than clinical threshold symptoms of delirium evaluated by the CAM-ICU-7 (score: 1–2) and ICDSC (score: 1–3) were 30.3% (95%CI:24.5–36.7) and 50.9% (95%CI:44.3–57.6). The CAM-ICU-7 and ICDSC had significant positive correlation (0.58, p<0.001). Agreement between the tools as measures of delirium was moderate (kappa = 0.51) and as measures of less than clinical threshold symptoms of delirium was fair (kappa = 0.21). Less than clinical threshold symptoms of delirium identified by the ICDSC, not CAM-ICU-7, were associated with prolonged length of ICU stay (≥7 days) in patients <65 years of age [Odds Ratio (OR) 9.2, 95% CI:2.5–34.0] and mechanical ventilation (receipt: OR 2.8, 95% CI:1.3–6.4; ≥96 hours: OR 6.6, 95% CI:1.9–22.9), when compared to patients with no delirium.

Conclusions

The CAM-ICU-7 and ICDSC are measures of the spectrum of delirium severity that are closely correlated. Less than clinical threshold symptoms of delirium measure by the ICDSC is a better predictor of outcomes, when compared with the CAM-ICU-7.
Exploring the changing geographical pattern of international scientific collaborations through the prism of cities
Authors: Csomós György , Vida Zsófia Viktória , Lengyel Balázs
Published: November 2020

Science is becoming increasingly international in terms of breaking down walls in its pursuit of high impact. Despite geographical location and distance still being major barriers for scientific collaboration, little is known about whether high-impact collaborations are similarly constrained by geography compared to collaborations of average impact. To address this question, we analyze Web of Science (WoS) data on international collaboration between global leader cities in science production. We report an increasing intensity of international city-city collaboration and find that average distance of collaboration of the strongest connections has slightly increased, but distance decay has remained stable over the last three decades. However, high-impact collaborations span large distances by following similar distance decay. This finding suggests that a larger geographical reach of research collaboration should be aimed for to support high-impact science. The creation of the European Research Area (ERA) represents an effective action that has deepened intracontinental research collaborations and the position of the European Union (EU) in global science. Yet, our results provide new evidence that global scientific leaders are not sufficiently collaborative in carrying out their big science projects.
Ultrasonographic evaluation of the effects of the administration of neostigmine and metoclopramide on duodenal, cecal, and colonic contractility in Arabian horses: A comparative study
Authors: Beder Noha Abdallah , Mourad Ahmed Atef , Aly Mahmoud Allam
Published: November 2020

Background and Aim: As means for enhancing gastrointestinal (GI) motility, prokinetics have previously been evaluated in different breeds of horses with varying success. No previous studies were conducted to evaluate the effect of prokinetics on the intestinal tract of Arabian horses breed. Using B-mode ultrasound in the quantification of intestinal contractility, this study aimed to compare the impact of neostigmine and metoclopramide on the intestinal motility of healthy Arabian horses.

Materials and Methods: Twenty-one clinically healthy Arabian horses were equally distributed into three groups. The control group was administered with 5 mL normal saline intramuscularly (IM). The second group was administered with neostigmine (0.044 mg/kg body weight [BW], IM), and the third group was administered with metoclopramide (0.25 mg/kg BW, IM). Duodenal, cecal, and colonic contractions were counted through ultrasonography for 3 min (pre-administration and 15, 30, 60, 120, and 180 min post-administration).

Results: In the neostigmine group, a significant (p<0.05) increase in duodenal, cecal, and colonic contractions was observed 15 min post-administration compared with that in the control group (15±1.0, 11.33±1.53, and 12.33±2.31 vs. 11.0±2.0, 6.33±0.58, and 5.33±0.58 contractions per 3 min, respectively), continuing to 60 min post-administration for the duodenum and cecum and 120 min for colon and then returning to the normal; however, the metoclopramide group showed a significant (p<0.05) increase only in cecal and colonic contractions 60 min post-administration compared with the control group (11.0±1.0 and 12.33±0.58 vs. 6±1.0 and 5.67±0.58 contractions per 3 min, respectively), continuing until the end of the experiment. Excessive sweating, excitation, and straining were recorded following the administration of neostigmine, whereas no side effects were observed in the metoclopramide group.

Conclusion: Neostigmine improves duodenal, cecal, and colonic contractions in healthy adult Arabian horses, whereas metoclopramide only improves cecal and colonic contractions. Metoclopramide appears to be safer and longer acting than neostigmine in the Arabian horse breed. Ultrasonography is a valuable noninvasive tool for the quantification of intestinal contractility. Future studies should consider the use of various dosages of metoclopramide and administration routes and investigate its impact on horses with GI transit disorders and inclusion in colic post-operative care.
Decolonialidade e futebol: a quebra da lógica periferia-centro
Authors: Pizarro Juliano Oliveira , Rial Carmen Silvia de Moraes , Rigo Luiz Carlos
Published: November 2020

Com o “descobrimento” do continente americano teve início o que muitos chamam de sistema-mundo moderno. Mesmo após a independência dos países que eram colônias de grandes potências europeias, a colonização não teve fim. Ela continua até hoje, principalmente através do chamado sistema neoliberal. Contudo, a globalização não apenas manteve a lógica da colonialidade econômica, mas também no aspecto cultural. Assim, se criou os estudos subalternos, tendo em vista criar teorias do sul global para o sul, fazendo necessário um processo de decolonização. O presente trabalho versa sobre como o futebol, considerado como o esporte mais praticado do mundo, apesar de mostrar as facetas mais preconceituosas da sociedade e a lógica colonial, é um instrumento extremamente importante no processo decolonial, fazendo que se quebre a lógica periferia-centro tradicional do atual sistema-mundo.
Ensaio acerca das curvas de sobrecarga da COVID-19 sobre a atenção primária
Authors: Savassi Leonardo Cançado Monteiro , Dias Bedetti Aline , Joi de Abreu Allan Braga , Costa Ana Caroline , Perdigão Ruth Martins da Costa , Ferreira Tiago Pedrosa
Published: November 2020

A atual pandemia de COVID-19 vem ocasionando sobrecarga nos sistemas de saúde em todo o mundo e comprometendo as diversas esferas que compõem esses sistemas. Dentre elas, destaca-se a Atenção Primária à Saúde – APS que é responsável por realizar o primeiro contato com o usuário que procura o Sistema Único de Saúde – SUS. Assim, verifica-se que um grande número de casos do Novo Coronavírus aumenta a demanda no trabalho da APS, o que contribui para a saturação do sistema e dificulta a realização dos atendimentos/acompanhamentos que já eram pauta em seus serviços, surgindo e agravando as comorbidades clínicas. O presente artigo propõe apresentar o modelo das três ondas de sobrecarga da APS e discutir seu papel no atual momento de minimizar os impactos dessa demanda elevada e garantir à população os princípios que a regem. Com base na importância que a APS tem no suporte assistencial à população, conclui-se que, além de suprir a demanda espontânea, ela é uma ferramenta importante no achatamento das ondas de contágio e também na contenção das consequências indiretas do SARS-CoV-2.
Proposta de protocolo de ensaio para análise de regeneração em misturas asfálticas através do modelo S-VECD
Authors: Pivetta Felipe Do Canto , Nascimento Luis Alberto Herrmann do , Brito Lélio Antônio Teixeira
Published: November 2020

Os fenômenos associados aos efeitos de fadiga e regeneração viscoelástica de materiais asfálticos têm sua importância já reconhecida em diversos trabalhos. O presente estudo aplica o modelo S-VECD para o ensaio de fadiga à tração direta em deformação controlada de misturas asfálticas, com a inserção de períodos de repouso com o objetivo de analisar a capacidade de regeneração do material. A partir dos dados obtidos em diferentes períodos de repouso, temperaturas de ensaio e níveis de integridade do material, apresenta-se uma variável de estado de regeneração (H) capaz de modelar estas condições em um parâmetro único. A inserção desta variável de estado em um modelo que quantifica a regeneração do material (%HS) no espaço da sua curva característica de dano – C versus S – fornece uma ferramenta que prevê com precisão o índice de regeneração da mistura avaliada.
A escolha de não ser discreto: discutindo a utilização de modelos discretos contínuos no transporte de carga
Authors: Tapia Rodrigo Javier , Larranaga Ana Margarita , Cybis Helena Beatriz , De Jong Gerard
Published: November 2020

O transporte de carga tem utilizado os modelos herdados do transporte de passageiros e com eles todos seus pressupostos tradicionais. Mas são todos eles válidos? O presente artigo visa discutir sobre um dos pressupostos menos contestados neste processo de modelagem: o da exclusividade mútua das alternativas no contexto do transporte de carga. Para isso, este artigo apresenta uma aplicação de Multiple Discrete Extreme Value Model (MDCEV) para a escolha de modo e porto para os consolidadores de grãos na Argentina. O modelo é desenvolvido a partir de uma pesquisa de Preferência Declarada que permitia a escolha de mais de uma alternativa simultaneamente. A escolha é descrita pelo Tempo de Viagem, Tempo de Espera do Serviço, Preço de venda no porto e Custo do Frete. O MDCEV permitiu obter informação sobre o efeito da saciedade das diferentes alternativas. De esta maneira, o MDCEV pode ser uma ferramenta valiosa para a modelagem de escolhas táticas e estratégicas.
ARTIFICIAL NEURAL NETWORK APPROACH FOR THE IDENTIFICATION OF CLOVE BUDS ORIGIN BASED ON METABOLITES COMPOSITION
Authors: Rustam . , Gunawan Agus Yodi , Kresnowati Made Tri Ari Penia
Published: November 2020

This paper examines the use of an artificial neural network approach in identifying the origin of clove buds based on metabolites composition. Generally, large data sets are critical for an accurate identification. Machine learning with large data sets lead to a precise identification based on origins. However, clove buds uses small data sets due to the lack of metabolites composition and their high cost of extraction. The results show that backpropagation and resilient propagation with one and two hidden layers identifies the clove buds origin accurately. The backpropagation with one hidden layer offers 99.91% and 99.47% for training and testing data sets, respectively. The resilient propagation with two hidden layers offers 99.96% and 97.89% accuracy for training and testing data sets, respectively.
KARAKTER WUJUD BANGUNAN ARSITEKTUR STASIUN KERETA API LAMA (HERITAGE) DI JALUR CIBATU-CIKAJANG
Authors: Nadya Janne , Ikaputra Ikaputra
Published: November 2020

Karakter arsitektur menjadi salah satu perwujudan kebudayaan yang  membentuk sebuah identitas. Stasiun jalur Cibatu-Cikajang merupakan salah satu wujud arsitektur yang dibangun kolonial Belanda yang menggambarkan identitas dari kota Garut. Tujuan dari penelitian ini menemukan karakter wujud arsitektur bangunan stasiun lama pada jalur Cibatu-Cikajang. Penelitian dilakukan dengan metode deskriptif kualitatif yang menemukan dan mendeskripsikan karakteristik wujud arsitektur berdasarkan perusahaan N.I.S x S.S. dan perusahaan S.S. Penelitian ini memerlukan data dalam mengungkap fakta dengan studi literatur, observasi lapangan, wawancara, dokumentasi sejarah stasiun pada media pendukung. Hasil dari penelitian menemukan adanya karakter dari masing-masing stasiun yang dinaungi oleh perusahaan NISxSS dan perusahaan SS.
Multiple solutions for weighted Kirchhoff equations involving critical Hardy-Sobolev exponent
Authors: Shen Zupei , Yu Jianshe
Published: November 2020

In this article, we consider a class of Kirchhoff equations with critical Hardy-Sobolev exponent and indefinite nonlinearity, which has not been studied in the literature. We prove very nicely that this equation has at least two solutions in ℝ3. And some known results in the literature are improved.
Predictive Processing during a Naturalistic Statistical Learning Task in ASD
Authors: Wagley Neelima , Lajiness-O’Neill Renee , Hay Jessica S. F. , Ugolini Margaret , Bowyer Susan M. , Kovelman Ioulia , Brennan Jonathan R.
Published: November 2020

Children’s sensitivity to regularities within the linguistic stream, such as the likelihood that syllables co-occur, is foundational to speech segmentation and language acquisition. Yet, little is known about the neurocognitive mechanisms underlying speech segmentation in typical development and in neurodevelopmental disorders that impact language acquisition such as autism spectrum disorder (ASD). Here, we investigate the neural signals of statistical learning in 15 human participants (children ages 8–12) with a clinical diagnosis of ASD and 14 age-matched and gender-matched typically developing peers. We tracked the evoked neural responses to syllable sequences in a naturalistic statistical learning corpus using magnetoencephalography (MEG) in the left primary auditory cortex, posterior superior temporal gyrus (pSTG), and inferior frontal gyrus (IFG), across three repetitions of the passage. In typically developing children, we observed a neural index of learning in all three regions of interest (ROIs), measured by the change in evoked response amplitude as a function of syllable surprisal across passage repetitions. As surprisal increased, the amplitude of the neural response increased; this sensitivity emerged after repeated exposure to the corpus. Children with ASD did not show this pattern of learning in all three regions. We discuss two possible hypotheses related to children’s sensitivity to bottom-up sensory deficits and difficulty with top-down incremental processing.
Between Beethoven and Mendelssohn: Biographical Constructions of Berlioz in the London Press
Authors: Cormac Joanne
Published: November 2020

In 1853 a writer for the London-based periodical Fraser's Magazine remarked that Berlioz's “heroic temperament” could be “read legibly in the noble style of his compositions. His own life forms to these works the most interesting accompaniment and commentary.” The linking of life and work in Berlioz's case is nothing unusual. However, a particular set of circumstances unique to London meant that critics based in that city persistently used Berlioz's biography to further their own agendas while also promoting his music. In this article, I argue that, when writing about Berlioz's London performances, critics employed biographical ideas and narratives that enabled them to use the composer as a means to shape local debates about the future of London's orchestral institutions: the Philharmonic Society and its latest “rival”: the New Philharmonic Society.

Biography proved a powerful rhetorical device from which Berlioz profited and is central to our understanding of his critical reception in London. It was used to introduce, to persuade, to simplify, to generate sympathy, admiration, and outrage. However, I reveal that in later visits biographical narratives overshadowed the coverage of Berlioz's music. In some articles, Berlioz was reduced to a rhetorical device to be employed to give strength to criticisms of either the old Philharmonic or the new, with the critic offering little insight into Berlioz's music. Biography had given Berlioz a foothold in musical London, but it could not win him the lasting success he craved.
SCIENCE SERVERS THE FUTURE To the 80th anniversary of Academician of NAS of Ukraine Gennadiy G. Pivnyak
Authors:   Institute of Electrodynamics of the National Academy of Sciences of Ukraine, Kyiv, Ukraine, Kyrylenko Olexandr V.
Published: November 2020

October 23, 2020 marks the 80th anniversary of the famous Ukrainian scientist in the field of electricity, twice laureate of the State Prize of Ukraine in Science and Technology (1998, 2005), Honored Worker of Science and Technology of Ukraine (1990), laureate of the S.O. Lebedev Prize of the NAS of Ukraine (1996), Rector of the Dnipro University of Technology (since 1982), Doctor of Technical Sciences (1981), Professor (1983), Academician of the NAS of Ukraine (1997) G.G. Pivnyak.
Financial Interventions to Increase Vaccine Coverage
Authors: Attwell Katie , Seth Rebecca , Beard Frank , Hendry Alexandra , Lawrence David
Published: November 2020

BACKGROUND:

Recent vaccine mandates in Australia, as in other high income settings, have sought to change the behavior of parents, including those who would otherwise access nonmedical exemptions. Since 2014, Australian state governments have introduced and progressively tightened policies restricting the access of unvaccinated children to early education and child care. In 2016, the Federal Government removed financial entitlements and subsidies from nonvaccinating families. We sought to ascertain the impact of these policies on vaccine coverage rates by state, and also to consider their impact on communities with high numbers of registered refusers.

METHODS:

Interrupted time series models were fitted by using the Autoregressive Integrated Moving Average framework to test for changes in trend in vaccination rates following implementation of government policies.

RESULTS:

Australian vaccine coverage rates were rising before the vaccine mandates and continued to do so subsequently, with no statistically significant changes to coverage rates associated with the interventions. The exception was New South Wales, where vaccine coverage rates were static before the policy intervention, but were increasing at an annual rate of 1.25% after (P < .001). The impact of the policies was indistinguishable between communities with high, medium and low numbers of registered vaccine refusers.

CONCLUSIONS:

In our study, we show that childhood vaccine coverage continued on its positive trajectory without any conclusive evidence of impact of mandatory policies. Overseas policymakers looking to increase coverage rates would be well-advised to examine the contribution of pre-existing and parallel nonmandatory interventions employed by Australian governments to the country’s enhanced coverage.
Kéntros, another Term of Mesopotamian Origin in the Ethiopian Astronomy
Authors: Lourié Basil
Published: November 2020

The Ethiopic term kentros “1/30” goes back to Akkadian mišlu through a lost meaning of the Greek astronomical term κέντρον.
Fasil Yitbarek, Soaring on Winged Verse: The Life of Ethiopian Poet-Playwright Tsegaye Gabre-Medhin
Authors: Krzyzanowska Magdalena
Published: November 2020

Review
Judith and the Dragon: A Jesuit architectural relief from Gorgora Iyäsus church, 1626–1632
Authors: Fernández Víctor M. , De Torres Jorge , Martinez d'Alòs-Moner Andreu , Cañete Carlos , Bausi Alessandro , Belay Gashaw
Published: November 2020

In the 2014 excavations at the Jesuit church of Gorgora Iyäsus on the northern shore of Lake Ṭana a remarkable relief in stone was unearthed. The relief was originally part of the church’s façade. It represents the biblical heroine Judith over a dragon and it contains two inscriptions in Gǝʿǝz from the Book of Judith and Genesis. This piece represents one of the few recorded inscriptions on stone from the end of the Aksumite period to the present time. The article focuses on the historical context that witnessed the production of this relief and provides an interpretation of its iconography.
‘L’Ascension du Ras Tafari & la Naissance de l’Éthiopie Moderne (1916–1930)’, Pount
Authors: Rubinkowska-Anioł Hanna
Published: November 2020

Review
A systematic review of epidemiological, causal status and policy-making issues of maternal mortality in Iran
Authors: Babaey Farah , Raeissi Pouran , Ravaghi Hamid
Published: November 2020

Background: Maternal mortality rate is not only an indicator of the quality level of maternal care but also represents the socio-economic status of any country. Maternal mortality had a decreasing trend in Iran during the last 24 years. Since preventable maternal mortality rate should be decreased to zero by 2030, effective planning and management in this regard are more needed.Aim: This study aims to review the maternal mortality status in Iran systematically.Method: This systematic review was designed and conducted in 2016. The information was gathered from searching databases including PubMed, Cochrane, Elsevier, Scopus, and also national databases including SID, Medlib, MagIran, IranMedex, and IranDoc. The selected time interval for searching was the studies published between 1985 and 2016. Meta-analysis statistical methods were used to calculate the maternal mortality rate.Result: There were 26 studies related to the study objectives were included and analyzed. The mean and standard deviation of the age of maternal mortality was estimated to be 30.8Â±5.6 years. Of the 15 studies mentioning types of termination of pregnancy, they showed the maternal mortality rates of 44% in natural childbirth, 52% in cesarean section, and 4% during pregnancy.Conclusion: This study emphasizes the importance of leading and guiding studies and knowledge management to complete the knowledge cycle for maternal mortality. Considering the disparities in regions, the interventions should take into account the socioeconomic factors as well as improving roads and transportation system and women literacy level.
The safety of modified digital subtraction angiography in RSPAD Gatot Soebroto: a comprehensive outlook
Authors: Putranto Terawan Agus , Astoro Nyoto Widyo , Rachmad Basuki , Setiawan Erwin , Pramono Ardianto , Djuwita Djuwita , Ikrar Taruna
Published: November 2020

INTRODUCTION. There are no recent estimates of the complication rate associated with Intra Arterial Heparin Flushing (IAHF). The purpose of this study was to estimate the rate of complication occurring during and after Intra Arterial Heparin Flushing.METHOD. This report is a descriptive study based on analysis of interventional radiology database. The study involved patients who underwent IAHF procedure started from January 2018 until December 2018 in Rumah Sakit Pusat Angkatan Darat Gatot Soebroto (Indonesian Army Central Hospital). Subjects were assessed for their age, sex, medical history, diagnosis, intra-procedural complication, and post-procedural complication.RESULT. All IAHF procedures were performed via transfemoral catheterisation and using a vascular closure device to help achieve homeostasis. Our population included 1223 (70,57%) male and 510 (29,43%) Female, with age ranging from 21 to 80 years old. The majority of the subject was in 51-60 years old age group (35,31%). All IAHF were technically successful. No intraprocedural complication was noted, there was no occurrence of iatrogenic vessel injury (dissection) and no neurological deficit secondary to IAHF procedures. There was some local complication after IAHF procedure such as hematoma 44 persons (2,54%), oedema around the puncture site six patients (0,35%), and bleeding at the puncture site three patients (0,17%). Beside local complication, there were several systemic complications such as allergy in 10 persons (0,58%). No neurological complication was reported after IAHF.CONCLUSION. We concluded that IAHF has a relatively low rate of acute complication. Most complications were related to local hemostasis control, and no severe sequelae were found.
Reincarnation-Balinese local wisdom as supportive therapy in the elderly with depression: a case study
Authors: Diniari Ni Ketut Sri
Published: November 2020

Background: Reincarnation (reborn after death), is a Hindu belief in Bali where it is proven by 'ngaluwang' ritual. In this ritual, every person who has a newborn baby will ask the help of Â 'orang pintar' to find out whose atman (spirit) has manifested in the baby. By returning to the world, there is no more sadness or feeling of loss in the elderly who suffers from the death of a spouse or other family member. This case study aims to know the reincarnation as supportive therapy for the elderly with depression.Case Description: A qualitative case study with in-depth interviews has been conducted by 2 (two) elderly people with a history of depressive disorders from the community. The first case came from a retired woman 72 years old and other case was derived from a female-farmer 80 years old. Face-to-face interview assessment has been evaluated to the cases and narrative synthesis about the findings has been written by qualitative approach. Â From the case study, the elderly experienced improvement in depressive symptoms, where feelings of loss, sadness, loneliness, guilt and hopelessness disappeared after the return of dead family membersâ€™ spirits into the world. The reincarnation of a loved one makes sadness and loss cease to exist, so symptoms of depression are healed.Conclusion: Reincarnation, which is believed to be a particular culture or religion, is a part of local wisdom that can provide healing of depression symptoms in the elderly.
The effectiveness of puzzle therapy on cognitive functions among elderly with dementia at Balai Pelayanan Sosial Tresna Werdha (BPSTW) Yogyakarta, Indonesia
Authors: Erwanto Rizky , Kurniasih Dwi Endah
Published: November 2020

Background: People with Alzheimer's dementia can experience a disruption in their daily activities, which can increase the burden of treatment costs. Puzzle therapy can encourage the release of the expression of the person living with Alzheimer's through artistic expression and creative processes. This study aims to determine the effectiveness of puzzle therapy on cognitive function of elderly dementia.Methods: A quasi-experimental approach using pre-post with control group design was used in this study. Â The number of respondents in the intervention group was 44 and in the control group was 27. The cognitive function on the elderly was assessed by the questionnaire of the Hopkins Verbal Learning Test (HVLT). Data were analyzed using SPSS version 17 for Windows. Bivariate paired T-test and Independent T-test were used in this study.Results: There was a significant increase in the mean value of cognitive function among the intervention group (2.16Â±2.67; P=0.013) after puzzle therapy. The intervention group without dementia was also found significantly increase (2.10Â±2.19; 0.000). While in the control group who had dementia obtained a non-significant decrease in cognitive functions (0.29Â±0.75; 0.356). However, the control group without dementia was found to be significantly increased (0.5Â±0.7; 0.008) in the cognitive function.Conclusion: Puzzle therapy intervention can improve cognitive scores significantly in all elderly people.
The correlation of High-Density Lipoprotein (HDL) with adiponectin levels among obese adolescents in Denpasar, Bali, Indonesia
Authors: Wahyuni Ni Luh Gede , Arimbawa I Made , Kardana I Made , Suarta Ketut , Artana I Wayan Dharma , Adnyana I Gusti Agung Ngurah Sugitha
Published: November 2020

Background:Â Obesity is a state of Body Mass Index (BMI) above or equal to 25 kg/m2. In obesity, dyslipidaemia can occur alone or together with other comorbid. This situation could affect pro-inflammatory and anti-inflammatory cytokines that lead to health problems. Several parameters assessed in dyslipidaemia conditions include High-Density Lipoprotein (HDL) and adiponectin. This study aims to evaluate the correlation between HDL and adiponectin levels in obese adolescents.Â Methods:Â A cross-sectional observational study was conducted among 33 obese adolescence (0-18 years) who met the inclusion criteria at Junior and Senior High School in Denpasar during August 2018-January 2019 period. Variables evaluated in this study were age, sex, weight, height, BMI, HDL, and adiponectin. The correlation assessment of HDL and adiponectin levels was conducted by Partial Correlation test after controlling age and sex using SPSS version 23 for Windows.Â Results:Â Males (66.70%) were predominant than females (33.30%) with a ratio of 2:1. The average age of respondents was 15.51Â±0.70 years old. The mean body weight was 91.04Â±15.40 kilograms, followed by height (163.09Â±7.40 cm), BMI (34.08Â±3.90 kg/m2), HDL (43.40Â±8.00 mg/dl), and adiponectin (4.55Â±2.1 Âµg/ml). There was a very weak and not significant correlation by Partial correlation test (r=0.143; p=0.444) between HDL and adiponectin levels.Conclusion:Â Our study found There was a very weak and not significant correlation between HDL and adiponectin levels among obese adolescent in Denpasar, Bali, Indonesia
Music and video music therapy are effective in reducing stress among elderly at Yogyakarta Social Service Center of Tresna Werdha, Abiyoso Pakem Unit, Sleman regency
Authors: Amigo Thomas Aquino Erjinyuare , Mariati Mariati
Published: November 2020

Background: The elderly will experience several physical and psychological changes. Such problems will inevitably lead to stress in the elderly. The prevalence of stress events in the elderly in Indonesia is 8.34% and at Yogyakarta Social Service Center of Tresna Werdha, Abiyoso Pakem Unit, Sleman is 38.4%. If left unchecked, stress can result in a prolonged depression. This study aims to identify the effectiveness of music and music video on stress in the elderly at Yogyakarta Social Service Center of Tresna Werdha, Abiyoso Pakem Unit, Sleman.Methods: A quasi-experimental study with Pre-and Post-test without control design were conducted. The number of respondents was 24, whereas taken by Simple Random Sampling approach. The music intervention was given to the 12 respondents and music video intervention to the 12 respondents. Stress was measured using DASS. Data were analyzed using paired T-test to determine the effectiveness of therapy and Independent T-test to evaluate the differences in therapy using SPSS version 17 for Windows.Results: Based on age, the respondents with 60-74 years were predominant (83.3%). Most of the respondents were female (79.2%). The analysis using Paired T-test indicated that there was a significant relationship of music therapy on the elderly (P<0.05). In addition, a significant result in reducing stress was also found in the music-video group on the elderly (P<0.05).Conclusion: Music and music video therapies are effective to reduce stress in the elderly.
A Randomised Controlled Trial: The effect of oral astaxanthin as an anti-inflammatory agent on serum level of e-selectin in acne vulgaris
Authors: Irawanto Muhammad Eko , Kariosentono Harijono , Purwanto Bambang , Pamungkasari Eti Poncorini
Published: November 2020

Background:Â E-selectin plays a pivotal role in the inflammatory response of acne. Astaxanthin (AST), an supplement claimed having anti-inflammatory and antioxidant properties, has potential in inflammatory skin therapy. This study aims to determine the effect of oral ASTÂ as an anti-inflammatory agent on the serum level of e-selectin in acne vulgaris.Â Methods:Â This is a double-blind, randomized controlled trial study with a pretest and posttest control group design. The participants were 34 acne vulgaris patients with inflammatoryÂ lesions (papulopustular acne). The participants are randomly assigned to the treatment or control group to receive oral tablet of 4 mg of AST or placebo in addition to standard acne therapy of tretinoin cream 0.025% and clindamycin cream 1.2%. Each group was measured for the serum level of E-selectin before therapyÂ (pretest) and after one month of therapy (posttest).Â Results:Â The pretest and posttest level of the mean serum e-selectin in the treatment Â group were 50.21 Â± 21.12 ng/ml and 50.04 Â± 22.99 ng/ml, respectively. There is no significant difference between the pretest and posttest of the mean e-selectin level in the treatment group (p=0.943). While, the pretest and posttest of mean serum e-selectin level in control group were 57.84 Â± 20.71 ng/ml and 55.87 Â± 15.98 ng/ml, respectively. There is no significant difference between the pretest and posttest of the mean e-selectin level in the control group (p=0.453).Â There was a decrease in the mean serum e-selectin level of the treatment and control groups one month after therapy. However, the decrease of the mean e-selectin level between treatment and control group is not significantly different (p=0.547).Conclusion:Â The addition of oral AST to standard acne therapy shows no significant difference in reducing the serum e-selectin level compared to placebo.
Diagnostic Accuracy of Bone Marrow Morphology to Determine Remission in Acute Lymphoblastic Leukemia Children: The Role of Minimal Residual Disease
Authors: Salim Elizabeth Joan , Ariawati Ketut , Gustawan I Wayan , Windiani I Gusti Ayu Trisna , Gunawijaya Eka , Hartawan I Nyoman Budi
Published: November 2020

Background: Relapse in acute lymphoblastic leukemia (ALL) patients are still widely found even though most patients experience remission at the end of the induction phase. Inaccurate determination of remission status due to the remaining leukemic cells that cannot be detected by bone marrow morphology examination is thought to play a considerable role in the occurrence of relapse.Objective: To measure the accuracy of the bone marrow morphology in determining remission at the end of the induction phase of ALL.Methods: Diagnostic tests were carried out in pediatric ward and laboratory of Sanglah Hospital and Dharmais Cancer Hospital Jakarta in January 2017 to March 2019. Bone marrow morphology and minimal residual disease (MRD) test was performed on ALL children at the end of the induction phase. Minimal residual disease is the gold standard.Results: Forty subjects with a median age of 5 years were included in this study. The median duration of induction phase was 75 days. Thirty-eight subjects (95%) had complete remission by bone marrow morphology, while only 16 (40%) subjects had complete remission by MRD. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of bone marrow morphology in this study were 100%, 8.3%, 42.1% and 100% respectively. Area under the curve (AUC) value of bone marrow morphology was 0.521 (95% CI 0.338 - 0.704).Â Conclusion: Bone marrow morphology has high sensitivity but low specificity and PPV in determining remission at the end of the induction phase of children with ALL.Â
Surgery in foreign body ingestion and aspiration: descriptive study
Authors: Semadi I Nyoman , Josua Josua , Sucipta I Wayan
Published: November 2020

Background: Foreign bodies in upper digestive tract, as well as respiratory tract, are common cases in daily life. This incident can occur in all age groups, ranging from children to elderly. Endoscopy and bronchoscopy are the first treatment option, nevertheless, case with complications which endoscopy or bronchoscopy cannot be done, it requires another extraction procedure specifically surgery.Method: We conducted a retrospective review of patients who came to consult to Thoracic Cardiovascular Surgery Department by ENT Department. The data obtained are from 2009-2019.Result: Out of 290 patients recorded, experiencing foreign body impaction in both digestive and respiratory tract for the last 10 years, the highest number was digestive tract with 243 cases (83.8%) and 47 respiratory tract cases (16.2%). From 17 patients who underwent surgery, 70.6% men and 29.4% women. The age group of children and adults had the same number as seven patients (41.2%) and elderly with three patients (17.6%). The highest number of surgical procedure was thoracotomy with 10 patients (58.8%) while cervical esophagotomy with seven patients (41.2%).Conclusion: The failure of the extraction procedure using endoscopy or bronchoscopy in the case of a foreign body leads to surgery as a definitive therapy for patients. The age group of children and adults have same number. Cases of impaction in the esophagus are the most common. The most common surgical procedure performed is thoracotomy. In this study the success rate of extraction by surgery reached 100% without additional morbidity and mortality.
Obstructive jaundice as manifestation of relapsing Hodgkinâ€™s Lymphoma: the success of chemotherapy (case report)
Authors: Yusuf Fauzi , Innayah Meutia Rizki , Maghfirah Desi , Azzaki Azzaki , Riswan M.
Published: November 2020

Background: Hodgkin's lymphoma is a hematologic malignancy of lymphocyte cells. Intrahepatic or extrahepatic disorders can cause jaundice associated with lymphoma. An extrahepatic obstructive jaundice due to lymphoma is still rarely reported, the incidence is only 1.3% out of 370 patients.Case Description: A male patient, 44 years old, admitted to the hospital because his eyes and all over his body became yellowish. He also felt itchy on his skin, and his stool color was pale. The patient was diagnosed with a post-chemotherapy relapse of Hodgkin's lymphoma twice with different regimens. The first chemotherapy was with the CHOP regimen. We evaluated the patient nine months after the chemotherapy with abdominal CT-scan, and we found paraaortic lymphadenopathy with infiltration to the spleen and gaster. Then, the patient was re-chemotherapy using Mesna's ICE regimen. Seven months after the second chemotherapy, the patient was re-admitted to the hospital with jaundice throughout his body. His laboratory results were 25.3 mg/dl for total bilirubin, 21.5 for direct bilirubin, 199 U/L for AST, 213 U/L for ALT, 469 mg/dl for ALP, and 6,400/mm3 for leukocytes. We found gall bladder hydrops and Intra-Hepatic Bile Duct Dilatation (IHBD) during an abdominal ultrasound examination. The results of the PET-scan showed multiple metastases to the peritoneal/omentum and diffuse lymphomatous infiltration in the gastric. After that, the patient was given the third chemotherapy with gemcitabine and vinorelbine regimens. His laboratory results in three weeks post-chemotherapy were, 6.4 mg/dl for total bilirubin, 5.87 mg/dl for direct bilirubin, 82 U/L for AST, and 36 U/L for ALT. We also found significant clinical improvement after the third chemotherapy.Conclusion: The diagnosis is difficult to establish because many other things can also cause obstructive jaundice. Chemotherapy is one therapeutic choice in the management of obstructive jaundice related to Hodgkin's lymphoma.
The effect of adding plantar flexors isometric exercise on calf circumference in patient with post open reduction internal fixation non-articular tibia fracture
Authors: Taufik Nasyaruddin Herry , Tulaar Angela Bibiana Maria , Haryadi Ratna Darjanti
Published: November 2020

Background: Post-operative non-articular tibia fracture some problems that often occur include pain, muscles atrophy, muscles weakness, and joint stiffness that makes patients limited in their daily activities. Several factors that play a role in muscles atrophy and weakness prolonged immobilisation and lack of exercise. Plantar flexor isometric exercise might effectively prevent the problem. Not yet known the effect isometric exercise of plantar flexor on calf circumference in patients post open reduction internal fixation of tibia fractures, due to the lack of studies in this field. The aim of investigating the effect of isometric exercise plantar flexor on calf circumference in patients post open reduction internal fixation non-articular tibia fracture.Methods: Study design using an experimental model with pre-test and post-test control group design divided into two groups, group A obtained treatment of isometric exercises of the plantar flexor muscles, range of motion knee and ankle joint while group B obtained a range of motion knee and ankle joint. Results: Descriptive analysis in group A there were 13 (81.3%) samples which increased calf circumference and 3 (18.7%) samples did not change while group B there were 4 (25%) samples increased calf circumference, 1 (6%) sample did not change and 11 (69%) samples were reduced calf circumference. The study was found increase mean calf circumference in group A was 0.76 cm and reduction mean calf circumference group B was 0.44 cm. Independent samples differences with Î± of 0.05 and confidence interval 95% was obtained p-value = 0.003, which has shown there is a significant difference in increased calf circumference group A obtained isometric exercises plantar flexor compared to group B without isometric exercises plantar flexor in patientsÂ  post open reduction internal fixation of a non-articular tibia fracture.Â Conclusion: The study found plantar flexor isometric exercise in patients post open reduction internal fixation non- articular tibia fracture enhances calf circumference that will prevent muscle calf atrophy and weakness.
Clinical characteristics of traumatic brain injury patients in Dr. Zainoel Abidin Public Hospital Banda Aceh, Indonesia
Authors: Syahrul Syahrul , Imran Imran , Fajri Nurul
Published: November 2020

Background: Traumatic brain injury (TBI) is responsible for more than one million hospital visits and causes disability and death in all age groups and genders. Every day, 153 people die from injuries including traumatic brain injury.Methods: We use a retrospective, cross-sectional study design. We collect data from patients admitted to our hospital on November 2018 that was diagnosed and treated for traumatic brain injury. The clinical information at follow-up was also analyzed.Â Results: We collected 60 cases of TBI, that consist of 35 male (58%) and 25 females (42%) with an average age of Â 18-39 years. 42% of patients had post-traumaticÂ amnesia. The leading cause of TBI was from motor vehicles accident, which constitutes to 90%, followed by falls (8%) and others (i.e. self-harm and assaults 2%). Glasgow Coma Scale (GCS) were examined, and we found 85% of patients presented with GCS scores â‰¥ 9 and 25% with score â‰¤ 8. Brain Ct scanning findings showed cerebral oedema (25%), epidural hemorrhage (18%), intracranial hemorrhage (15%), and subarachnoid haemorrhage (12%). Laboratory findings showed an increase of leukocyte count (80%), high segmented neutrophils count (72%), hyperglycemia after TBI (7%), hyponatremia (2%), hypernatremia (11%), hypokalemia (22%), hyperkalemia (17%) and hyperchloremia (30%).Conclusion: We reported 60 cases of TBI and collected demographic data upon patients arrival in the hospital, such as; GCS score, brain imaging and laboratory findings. This information can help prevention strategies, identify research and education priorities, and support service needs among those living with TBI.Â
Vitamin C and ubiquinone able to maintain sperm telomers length on infertileâ€™s men: a clinical trial at Doctor Soetomo Regional General Hospital, Surabaya, Indonesia
Authors: Pramesemara I Gusti Ngurah , Setiawan Androniko , Tanojo Tjahjo Djojo , Agustinus Agustinus , Hartono Judie
Published: November 2020

Background:Â Infertility is one of the clinical problems that affect medical and psychological conditions. An estimated 15% of couples in the world experience infertility and almost half occur on men. Excessive stress oxidation has been known responsible to the DNA damage and induces shortening of sperm telomere length. This study aims to determine the role of vitamin C and ubiquinone as antioxidants to maintain sperm telomers length among infertile men.Â Methods:Â An experimental clinical trial with a pre and post-test control group design has been conducted among 30 infertile men respondents at Doctor Soetomo Regional General Hospital, Surabaya. The respondents were divided into three groups: the combination of Vitamin C and Ubiquinone (P1), Vitamin C and Placebo (P2), and Ubiquinone and Placebo (P3) administration. All three groups were examined for pre- and post-test of sperm telomere length. Data were analyzed using SPSS version 21 for Windows.Results:Â Most of the respondents were origin from Surabaya (66.7%), never been treated (66.7%), normal BMI (46.7%), non-smoking history (66.7%), non-alcohol consumption (90.0%), having 22-25 of IIEF-5 Score (60.0%), no heat exposure (90.0%), no chemical exposure (73.3%), and diagnosis with primary male infertility (90.0%). No significant difference of sperm telomere length was found among three treatment groups (p>0.05) using Post-Hoc Test.Â Conclusion:Â There was no significant difference in sperm telomere length of infertile men among groups. All antioxidants used in this study have a similar ability to maintain or influence sperm telomere length in infertile men.
Osseous choristoma of the tongue: A rare disease
Authors: Te Boon Chin , Ahmad Mohd Ayzam , Mohamad Yunus Mohd Razif , Paiman Noorasmaliza Md
Published: November 2020

Choristoma is described as the growth of normal tissue in an unusual location. Intraoral choristoma may be comprised of various tissue types such as cartilage, bone, gastric mucosa and, even glial tissue. Osseous choristoma is a rare, benign normal bony tissue in an abnormal location, commonly over the dorsum of the tongue though cases at maxillofacial region have been reported. This entity should be kept in mind because it can be confused with other tumor and tumor-like lesions of the tongue. We report a case of lingual osseous choristoma along with discussion regarding its epidemiology, pathogenesis, clinical features, and treatment.