bluuebunny/crossref_metadata_2025 huggingface dataset:
The Advanced BRain Imaging on ageing and Memory (ABRIM) data collection: Study design, data processing, and rationale
Authors: Jansen Michelle G. , Zwiers Marcel P. , Marques Jose P. , Chan Kwok-Shing , Amelink Jitse S. , Altgassen Mareike , Oosterman Joukje M. , Norris David G.
Published: June 2024

To understand the neurocognitive mechanisms that underlie heterogeneity in cognitive ageing, recent scientific efforts have led to a growing public availability of imaging cohort data. The Advanced BRain Imaging on ageing and Memory (ABRIM) project aims to add to these existing datasets by taking an adult lifespan approach to provide a cross-sectional, normative database with a particular focus on connectivity, myelinization and iron content of the brain in concurrence with cognitive functioning, mechanisms of reserve, and sleep-wake rhythms. ABRIM freely shares MRI and behavioural data from 295 participants between 18–80 years, stratified by age decade and sex (median age 52, IQR 36–66, 53.20% females). The ABRIM MRI collection consists of both the raw and pre-processed structural and functional MRI data to facilitate data usage among both expert and non-expert users. The ABRIM behavioural collection includes measures of cognitive functioning (i.e., global cognition, processing speed, executive functions, and memory), proxy measures of cognitive reserve (e.g., educational attainment, verbal intelligence, and occupational complexity), and various self-reported questionnaires (e.g., on depressive symptoms, pain, and the use of memory strategies in daily life and during a memory task). In a sub-sample (n = 120), we recorded sleep-wake rhythms using an actigraphy device (Actiwatch 2, Philips Respironics) for a period of 7 consecutive days. Here, we provide an in-depth description of our study protocol, pre-processing pipelines, and data availability. ABRIM provides a cross-sectional database on healthy participants throughout the adult lifespan, including numerous parameters relevant to improve our understanding of cognitive ageing. Therefore, ABRIM enables researchers to model the advanced imaging parameters and cognitive topologies as a function of age, identify the normal range of values of such parameters, and to further investigate the diverse mechanisms of reserve and resilience.
Filmic construction of regional Islamophobia: Rendering Kashmiri Muslims in Hindi cinema
Authors: Majeed Tawseef
Published: June 2024

This article examines the representation of Kashmir and its people in Hindi cinema, particularly Kashmiri Muslims. Cinematic representation has contributed to a harmful perception of Muslim identity and Islam. Given the contemporary global religio-political scenario, it is crucial to examine this phenomenon in promoting such perceptions about Kashmir, which is often referred to as South-Asian Palestine. The methodology employs survey, dialogical deconstruction and narrative analysis to unearth the implicit significances within three selected films, Haider, Mission Kashmir and Roja, depicting the Kashmiri Muslim subjects and their effect on the youth. A survey of university youth was also conducted at three central universities in Delhi. The investigation reveals a prevalent theme of violence in these films, often giving negative and biased portrayals of Kashmiris. Such conscious constructions of negative characters and narratives perpetuate Kashmirophobia – the fear or prejudice against Kashmir and its people among the youth. The portrayal of Kashmiri Muslims in Bollywood aggravates communal narratives and reinforces discriminatory views about the community, affecting the perception of the audience towards Kashmiri Muslims.
Modeling airbursts by comets, asteroids, and nuclear detonations: shock metamorphism, meltglass, and microspherules
Authors: West Allen , Young Marc , Costa Luis , Kennett James P. , Moore Christopher R. , LeCompte Malcolm A. , Kletetschka Gunther , Hermes Robert E.
Published: June 2024

Asteroid and comet impacts can produce a wide range of effects, varying from large crater-forming events to high-altitude, non-destructive airbursts. Numerous studies have used computer hydrocode to model airbursts, primarily focusing on high-altitude events with limited surface effects. Few have modeled so-called “touch-down” events when an airburst occurs at an altitude of less than ∼1000 m, and no known studies have simultaneously modeled changes in airburst pressures, temperatures, shockwave speeds, visible materials, and bulk material failure for such events. This study used the hydrocode software Autodyn-2D to investigate these interrelated variables. Four airburst scenarios are modeled: the Trinity nuclear airburst in New Mexico (1945), an 80-m asteroid, a 100-m comet, and a 140-m comet. Our investigation reveals that touch-down airbursts can demolish buildings and cause extensive ground-surface damage. The modeling also indicates that contrary to prevailing views, low-altitude touch-down airbursts can produce shock metamorphism when the airburst shockwave or fragments strike Earth’s surface at sufficiently high velocities, pressures, and temperatures. These conditions can also produce microspherules, meltglass, and shallow impact craters. Regardless of modeling uncertainties, it is known that bolides can burst just above the Earth’s surface, causing significant damage that is detectable in the geologic record. These results have important implications for using shocked quartz and melted materials to identify past touch-down airbursts in the absence of a typical impact crater. Although relatively rare, touch-down events are more common than large crater-forming events and are potentially more dangerous.
Influence of planting speed on emergency uniformity and distribution of soybean plants
Authors: Siega Guilherme Arantes , Menezes Filho Antonio Carlos Pereira de , Sharma Porshia , Melo Aurélio Ferreira , Ventura Matheus Vinícius Abadia
Published: June 2024

Soybean is a crop of great economic importance, and the efficiency of its production depends on various agronomic factors, among which planting speed stands out due to its direct impact on seedling emergence and plant arrangement in the field. The main objective of this research is to analyze how different planting speeds affect the uniformity of plant emergence and the regularity of plant distribution. To achieve this objective, a comprehensive literature review was conducted, including previous studies that investigated the relationship between planting practices and soybean crop performance. The review results indicated that higher planting speeds tend to impair emergence uniformity due to seed damage and reduced deposition accuracy. This results in uneven emergence and irregular plant distribution, which can compromise homogeneous plant development and reduce yield. On the other hand, lower speeds provide more uniform emergence and more regular distribution, optimizing the use of resources such as light, water, and nutrients. It is concluded that reducing planting speed can significantly improve the uniformity of emergence and distribution of soybean plants, contributing to more efficient and higher-yielding production. It is recommended that producers adjust planting speed according to the specific conditions of their fields to maximize productive potential.
Responding to the environmental emergency through education: the imperative for teacher support across all subjects
Authors: Greer Kate , Walshe Nicola , Kitson Alison , Dillon Justin
Published: June 2024

The most recent Intergovernmental Panel on Climate Change report sets out sobering scenarios about the future for our young people and appeals for ‘deep, rapid, and sustained reductions in greenhouse gas emissions’. Although technological responses are essential to achieve these reductions, technocratic solutions alone will not solve the environmental emergency; a widespread societal transformation is needed. Education can play a profound role in this transformation as it is fundamental to building a society with knowledge, skills and motivation to tackle climate change so as to regenerate ecological and social systems. This commentary reflects on multiple dimensions of education’s role, focusing particularly on schools and the important contribution that all subjects can make towards developing interdisciplinary, complex understandings of the environmental emergency and living more sustainably. Drawing from a recent nationwide survey of teachers in England carried out by the UCL Centre for Climate Change and Sustainability Education, we highlight a troubling lack of engagement in formal professional development related to climate change and sustainability, even amongst a ‘climate change engaged’ cohort of teachers, and the imperative for comprehensive professional learning for teachers from across all subjects and year levels.
Unlocking Success: Nexus between Entrepreneurial Orientation and Financial Performance in Culinary MSMEs
Authors: Sucahyo Usil Sis , Damayanti Theresia Woro , Supramono Supramono
Published: June 2024

This study aims to investigate the impact of entrepreneurial orientation on the financial performance of micro, small, and medium-sized enterprises (MSMEs) in the culinary sector, while also exploring the mediating roles of digital transformation and working capital in this relationship. Data were gathered via a field survey involving 360 culinary MSMEs operators in Semarang City, Salatiga City, and Surakarta City, with a proportional distribution across these locations. Statistical analysis was conducted using SEM-PLS. The results reveal that entrepreneurial orientation significantly influences financial performance, digital transformation, and working capital. Additionally, digital transformation and working capital play mediating roles in the relationship between entrepreneurial orientation and financial performance. This study contributes to theoretical insights by proposing a model to enhance the economic performance of culinary MSMEs, focusing on entrepreneurial orientation, digital transformation, and working capital. From a policy perspective, the government is encouraged to support various initiatives aimed at enhancing entrepreneurial capabilities, fostering the adoption of digital technologies, and promoting effective working capital management within the culinary MSMEs sector.
Adipose Cells Induce Phospho-Thr-172 AMPK Production by Epinephrine or CL316243 in Mouse 3T3-L1 Adipocytes or MAPK Activation and G Protein-Associated PI3K Responses Induced by CL316243 or Aluminum Fluoride in Rat White Adipocytes
Authors: Ohsaka Yasuhito , Nishino H. , Nomura Y.
Published: June 2024

Responses of adipose cells to adrenoceptor regulation, including that of β-adrenoceptor (AR), and the signalling machinery involved in these responses are not sufficiently understood; information that is helpful for elucidating the adrenoceptor (adrenergic and β-AR)-responsive machinery is insufficient. We examined phospho-Thr-172 AMPK production in mouse-derived 3T3-L1 adipocytes treated with epinephrine or CL316243 (a β3-AR agonist) for 15 min. We also examined MAPK activation or G protein-associated PI3K activation or -associated PI3K p85 complex formation in rat epididymal (white) adipocytes treated with CL316243 for 15 min or aluminum fluoride (a G-protein signalling activator) for 20 min. Furthermore, we examined the effect of PTX (a trimeric G-protein inactivator) on p85 complex formation induced by aluminum fluoride treatment. Western blot analysis revealed that epinephrine or CL316243 treatment increased the phospho- Thr-172 AMPK (an active form of AMPK) level in 3T3-L1 adipocytes. Activated kinase analysis with a specific substrate showed that CL316243 or aluminum fluoride treatment activated MAPK in rat adipocytes. Immunoprecipitation experiments with a G-protein β subunit (Gβ) antibody showed that treatment of rat adipocytes with CL316243 activated PI3K and increased the PI3K p85 level in the Gβ antibody immunoprecipitates. Such an increase in the p85 level was similarly elicited by aluminum fluoride treatment in a PTX-sensitive manner. Our results provide possible clues for clarifying the signalling machinery involved in adrenoceptor responses, including those of β3-AR, in mouse-derived adipocytes and rat white adipocytes. Our findings advance the understanding of responses to adrenoceptor regulation in adipose cells and of the cellular signalling machinery present in the cells.
The Modified Ambiguity Function Approach with regularization for instantaneous precise GNSS positioning
Authors: Fischer Artur , Cellmer Sławomir , Nowel Krzysztof
Published: June 2024

The Modified Ambiguity Function Approach (MAFA) implicitly conducts the search procedure of carrier phase GNSS integer ambiguity resolution (IAR) in the coordinate domain using the integer least squares (ILS) principle, i.e. MAFA-ILS. One of the still open scientific problems is an accurate definition of the search region, especially in the context of instantaneous IAR. In doing so, the float solution results, which encompass float position (FP) and its variance-covariance (VC) matrix, must be improved as these are necessary for defining the search region. For this reason, the ambiguity parameters are separately regularized, and then the baseline parameters are conditioned on regularized float ambiguities. The conditional-regularized estimation is thus designed, obtaining the regularized FP (RFP) and its VC-matrix. This solution is promising because its accuracy is enhanced in the sense of mean squared error (MSE) thanks to the improved precision at the cost of regularized bias. The optimal regularization parameter (RP) values obtained for ambiguity parameters balance the contributions of improved precision and bias in the regularized float baseline solution’s MSE. Therefore, the regularized search region is defined accurately in the coordinate domain to contain such approximate coordinates that more frequently give the correct ILS solution. It also contains fewer MAFA-ILS candidates, improving the search procedure’s numerical efficiency. The regularized ILS estimator performs well with the presence of bias, increasing the probability of correct IAR in the coordinate domain.
Therapeutic ayurvedic interventions for the management of rheumatoid arthritis complicated by adhesive capsulitis – a case report
Authors: Khurana Bhavya , Dipankar Digambar G. , Saini Neha , Dubal Neha Suresh
Published: June 2024

Background

Rheumatoid Arthritis is an autoimmune disorder that leads to persistent symmetrical polyarthritis accompanied by systemic manifestations. It may lead to an array of deformities and even complications like rheumatoid nodules, carpal tunnel syndrome, adhesive capsulitis, cardiovascular diseases, and many more.

Objectives

This case report intends to discuss the ayurvedic management of Rheumatoid Arthritis which was complicated by Adhesive Capsulitis.

Methods

A 73-year-old male patient was diagnosed with Rheumatoid Arthritis. He had previously undergone allopathic treatment for a year. In June 2023, the patient sought ayurvedic treatment for his ailment and later acquired signs and symptoms of Adhesive Capsulitis. He was given ayurvedic oral medications along with external therapeutic procedures.

Results

There was a significant reduction in the values of the Routine Assessment of Patient Index Data 3 (RAPID3) score, Clinical Disease Activity Index (CDAI), Rheumatoid Factor (Quantitative), Visual Analogue Scale (VAS), and improvement in the range of movement of the affected joint.

Conclusions

Ayurvedic medicines are effective in managing Rheumatoid Arthritis along with the complication of Adhesive Capsulitis.
Prevention of preterm birth in twin-to-twin transfusion syndrome: a systematic review and network meta-analysis
Authors: Provinciatto Henrique G. , Barbalho Maria E. , Crosara Laura F. , Orsini Pedro V.B. , Provinciatto Alexandre , Philip Chris E. , Ruano Rodrigo , Araujo Júnior Edward
Published: June 2024

Objectives

We aimed to perform a systematic review and network meta-analysis to evaluate the preventive strategies for preterm birth in twin-to-twin transfusion syndrome.

Methods

PubMed, Embase and Cochrane Central were searched from inception to December 2023 with no filters. Additionally, the reference lists of the included studies were manually examined to identify any supplementary studies. We selected randomized controlled trials and cohorts comparing interventions to prevent preterm birth in twin pregnancies complicated by twin-to-twin transfusion syndrome. A random-effects frequentist network meta-analysis was performed using RStudio version 4.3.1. Randomized controlled trials and cohorts were assessed respectively using the Risk of Bias in Non-randomized Studies of interventions tool and Cochrane Collaboration’s tool for assessing risk of bias in randomized trials.

Results

In this systematic review and meta-analysis, we included eight studies comprising a total of 719 patients. Compared with expectant management, cerclage stood out as the only intervention associated with an increase in the survival of at least one twin (risk ratio 1.12; 95 % confidence interval 1.01–1.23). Our subgroup analysis based on different thresholds for short cervix demonstrated a significant reduction in the risk of preterm birth before 32 weeks with ultrasound-indicated cerclage using a 15 mm criterion (risk ratio 0.65; 95 % confidence interval 0.47–0.92).

Conclusions

Our study suggests the potential benefit of cerclage as a preventive strategy for preterm birth in pregnancies complicated by twin-to-twin transfusion syndrome. These findings highlight the necessity for further investigation to corroborate our results and address the optimal threshold for ultrasound-indicated cerclage.
Current Trends and Future Perspectives of Integrated Watershed Management
Authors: Vasić Filip , Caković Milica , Dragović Nada , Jovanović Nikola , Rončević Vukašin , Živanović Nikola , Zlatić Miodrag
Published: June 2024

The significance of Integrated Watershed Management (IWM) has increased in recent years due to its ecological, economic, and social implications. To align with these principles and achieve efficiency, watershed management necessitates the evaluation and integration of numerous diverse factors. This literature review aims to examine the current research trend in IWM and its association with various thematic elements. The identified thematic elements include water resources management, decision-making processes, agricultural and forested watersheds, soil management, natural hazards, stakeholder involvement, climate change, policy frameworks, cost management and risk analysis, livelihoods, ecosystem services, habitat and biodiversity conservation, and tourism. The predominant thematic elements were water resource management, decision-making, and agricultural and forested watersheds. The countries that were most frequently referred to in the examined literature were Ethiopia, China, the USA, and Iran. A synthesis of data obtained via the analysis of scientific research trends in the specified domain can serve as a basis for the establishment and strategizing of comprehensive watershed management. While it is important to consider all these aspects combined in IWM practice, it is also essential to have a comprehensive grasp of each factor as a vital step in integrating them. The participants involved in this endeavour, hailing from diverse professional backgrounds, must engage in close collaboration to successfully integrate the aforementioned aspects. The collaborative method can only have a chance of success if all participants involved demonstrate a high level of dedication. The level of dedication required should be grounded in a comprehensive understanding of the difficulties and demands that are mutually shared by all involved parties.
Thyroid-stimulating hormone induces insulin resistance in adipocytes via endoplasmic reticulum stress
Authors: Zhou Qing , Zhang Li Yong , Dai Mei Feng , Li Zhen , Zou Chao Chun , Liu Hui
Published: June 2024

Graphical abstract

Subclinical hypothyroidism (SCH) is closely related to insulin resistance, and thyroid-stimulating hormone (TSH) level is an independent factor for insulin resistance associated with subclinical hypothyroidism. This study aims to explore the effects of TSH levels on insulin signal transduction in adipocytes and to establish the role of endoplasmic reticulum (ER) stress in this process. In this study, the SCH mouse model was established, and 3T3-L1 adipocytes were treated with TSH or tunicamycin (TM), with or without 4-phenylbutyric acid (4-PBA), an inhibitor of ER stress. Subclinical hypothyroidism mice exhibited impaired glucose tolerance, inactivation of the IRS-1/AKT pathway, and activation of the IRE1/JNK pathway in adipose tissue, which can all be alleviated by 4-PBA. Supplementation with levothyroxine restored the TSH to normal, alongside alleviated ER stress and insulin resistance in SCH mice, which is characterized by improved glucose tolerance, decreased mRNA expression of IRE1, and decreased phosphorylation of JNK in adipose tissue. In 3T3-L1 adipocytes, TSH induces insulin resistance, leading to a decrease in glucose uptake. This effect is mediated by the downregulation of IRS-1 tyrosine phosphorylation, reduced AKT phosphorylation, and inhibited GLUT4 protein expression. Notably, all these effects can be effectively reversed by 4-PBA. Moreover, TSH induced TNF-α and IL-6 production and upregulated the expression of ER stress markers. Similarly, these changes can be recovered by 4-PBA. These findings indicate that TSH has the capability to induce insulin resistance in adipocytes. The mechanism through which TSH disrupts insulin signal transduction appears to involve the ER stress–JNK pathway.
METHODS OF FORMING UNIVERSITY COMMUNICATION CHANNELS IN DISTANCE WORK CONDITIONS
Authors: Grynevych L. V. , Mirzoiev D.
Published: June 2024

In the conditions of fierce competition in the market of educational services both in Ukraine and abroad, the issue of attracting applicants to study in institutions of higher education is gaining special relevance. At present, there are many negative external factors that do not contribute to positive dynamics regarding recruitment. Therefore, there is a need to define mechanisms and develop a strategy that will allow changes for the better in the situation with the recruitment of applicants. The first step on this path can be the formation of communication channels of the university with applicants. For this, it is necessary to have a clear plan of action on how to do it.
The purpose of the article is to justify the method of forming communication channels of the university in the conditions of remote work. It was developed for foreign applicants. The choice of this target audience is determined by the interests of the state related to the promotion of Ukrainian higher education institutions on the World and European educational markets.
The statistical method of observation was chosen as the research method, which made it possible to provide a quantitative and qualitative assessment of the needs of foreign applicants. As a tool, a questionnaire was developed and implemented, which made it possible to form a portrait of the consumer of educational services. The survey was conducted anonymously through the Google platform. The use of this platform made it possible to monitor the survey process, i.e. to draw a conclusion at the initial stage regarding the interest of foreign applicants and applicants in receiving education in Ukraine.
The methodology consists of 7 stages, the sequential implementation of which made it possible to single out and describe the channels of communication that should be used to communicate with foreign applicants. Thus, the proposed method of forming university communication channels in the conditions of remote work is of practical importance and can be used in the activities of higher education institutions.
ANALYSIS OF THE RELATIONSHIP BETWEEN SUPPLY CHAIN MANAGEMENT AND OUTSOURCING STRATEGIES IN FREIGHT TRANSPORTATION
Authors: Skochylias R. V. , Skochylias N. V.
Published: June 2024

In the rapidly evolving landscape of freight transportation, the key management systems and outsourcing strategies should be developed for best results, including the whole process optimizations, costs reduction as well as market competitivity improvement. In this paper, the authors seek to explore via in-depth study the subtle intricacies of the link between Supply Chain Management (SCM) decisions and the choice to outsource, in order to unearth unique considerations that will guide important strategic choices in the industry. This research first embodies a systematic literature review and theory and empirical study as well as practical cases from the real world. Finally, the authors present multi-dimensioning implications and practical policy recommendations for supply chain management related to outsourcing initiatives.
This research emphasizes the criticality of coordinating the SCM and the strategy for outsourcing to businesses that may be major players in the road and rail freight transportation sector. Strategy mapping generates both operational efficiency and adaptability as well as robustness which becomes a tool to tackle the complications of international supply chains thus allowing the enterprises to respond gracefully to dynamic markets. However, the research also highlights three factors of collaborative partnership, technological integration, and continuous improvement that determine the management and the supply chain outsourcing. Through creation of collaborative governance models, the deployment of advanced tech tools including AI, IoT and blockchain in addition to providing a culture a learning and improvisation, businesses can enhance their supply chain and outperform their competitors in the market space.
This research is a contributory factor, revealing the strategic consequences of balancing SCM and outsourcing for the businesses, policymakers, and stakeholders of the industry. It is a point of discussion related to a demand from enterprises for strategic planning processes and governance arrangements to take into account the SCM and outsourcing synergies. Moreover, it emphasizes the fact that administrators should be able to put in place regulations seen to enhance collaborations, discoveries, and funding to the technological projects.
Lastly, this research covered deeply all SCM-outsource aspects in this industry freight transportation. Through the extensive observation and the change of the suggested strategies, companies can create new openings for development, innovation, and sustainability in the midst of the world’s supply and logistics environment that is ever changing.
МАРКЕТИНГОВІ ДОСЛІДЖЕННЯ ЗАЛУЧЕННЯ ІНВЕСТИЦІЙ У ЛЮДСЬКИЙ КАПІТАЛ СФЕРИ КРЕАТИВНИХ ІНДУСТРІЙ ІВАНО-ФРАНКІВСЬКОЇ ОТГ
Authors: Благун І. І.
Published: June 2024

У статті розглянуто залучення інвестицій у людський капітал сфери креативних індустрій Івано-Франківської ОТГ, проаналізовано класифікацію видів економічної діяльності, яка входить до переліку креативних індустрій. Метою статті є дослідження інвестицій в освітні програми, які формують фахівців у сфері креативних індустрій. У процесі дослідження було використано кабінетні дослідження, а також методи: абстрагування, узагальнення та порівняльного аналізу.
Визначено, що найбільша сукупність освітніх програм, яка формує фахівців у сфері креативних індустрій, знаходиться у галузі 02 Культура і мистецтво. Результати дослідження дали можливість визначити освітні програми з  найбільшим рівнем інвестицій. Аналіз останніх досліджень та публікацій в даній темі дає можливість зрозуміти, що в умовах нестабільності креативні індустрії можуть стати драйвером розвитку ОТГ. Інвестиційний потенціал креативних індустрій складається як з внутрішніх ресурсів, так і зовнішніх. Проаналізовано витрати абітурієнтів, які інвестували в освітні програми, що дають можливість працевлаштування в креативних індустріях.
Уваги заслуговує кількість вступників, яка вступила на спеціальності сфери культури і мистецтва. Коливання аудиторії і її залучення притаманне як і державним, так і приватним вузам. Крім цього, варто зазначити рівень інвестицій в освіту по кожній освітній програмі. Також показано відповідність кількості студентів по кожній освітній програмі. Визначено освітні програми з найвищим рівнем кількості студентів. В цілому, варто зазначити, що інвестиційна оцінка в людський капітал в освітньому вимірі дає можливість для розвитку у креативному середовищі. Дана сфера перебуває в процесі постійної трансформації і розвитку, і буде об’єктом постійних досліджень як вчених, так і бізнес структур, які просувають свої товари чи послуги в цифровому середовищі. Проведене дослідження залучення інвестицій у людський капітал сфери креативних індустрій Івано-Франківської ОТГ має практичну значущість у сфері креативних індустрій, оскільки дає можливість аналізу залучення інвестицій в освітній сегмент креативних індустрій. Роль і місце інвестицій  в освіту в структурі інвестицій в креативні індустрії буде постійно зростати. Фірми будуть вдаватися до постійного пошуку кадрів в сфері культури і мистецтва. Адже показник залученості активності абітурієнтів здійснює постійний вплив на інші фактори культурного середовища. Цим в свою чергу і формується інвестиційний клімат в сфері надання освітніх послуг, який безпосередньо здійснює вплив на інвестиційний клімат креативних продуктів, визначенням їхнього місця в порівнянні з іншими продуктами в структурі економіки ОТГ.
A Molecular Docking and Dynamics Simulation Study on Prevention of Merozoite Red Blood Cell Invasion by Targeting Plasmodium vivax Duffy Binding Protein with Zingiberaceae Bioactive Compounds
Authors: Fikri Heikal Muhammad , Putra Wira Eka , Sustiprijatno  , Hidayatullah Arief , Widiastuti Diana , Lelitawati Mardiana
Published: June 2024

[Objective] Plasmodium vivax predominantly infects many people in numerous tropical areas, including Southeast Asia, the Western Pacific, the Americas, and the Eastern Mediterranean. The uniqueness of forming dormant stages can lead to relapse in vivax malaria upon further infection. This study used molecular docking and dynamic simulation to predict potential bioactive compounds from the Zingiberaceae plant family as inhibitors by targeting Plasmodium vivax Duffy Binding Protein (PvDBP). PvDBP-DARC molecular interaction is required to mediate the merozoite invasion process into red blood cells. Inhibiting this process can possibly control parasite growth and development. [Methodology] Molecular docking screening was conducted by using 138 natural compounds from the Zingiberaceae plant family targeting Plasmodium vivax Duffy binding protein (PvDBP). The top two compounds with the lowest binding energy were selected to be analyzed by pharmacokinetics prediction and molecular dynamic (MD) simulation. [Results] Molecular docking screening resulted in the top two compounds with the lowest binding energy value, including 5,7-dihydroxyflavanone (-9.3 kcal/mol) and pinostrobin (-9.2 kcal/mol). These compounds are predicted to have stronger interaction than chloroquine as a control. Furthermore, the potential compounds also interact with DARC binding site residues and maintain them during the molecular dynamic simulation process. Otherwise, chloroquine as a control cannot retain 75% binding residues towards PvDBP. A molecular dynamic study revealed that all three complexes have relatively similar stability. [Conclusions] We predicted that the two bioactive compounds (5,7-dihydroxyflavanone and pinostrobin) have the potential as merozoite invasion inhibitors.
La importancia de enseñar a argumentar al bachiller
Authors: Sánchez Rivera Virginia
Published: June 2024

Inicio con el posicionamiento teórico desde el cual hablo de argumentar, argumentación y argumento con referencia a la Teoría de la argumentación. Continúo con unas breves notas sobre la enseñanza y el aprendizaje de la argumentación. Igualmente señalo que el estudiante del bachillerato es en general un adolescente. Menciono el resultado de una investigación educativa realizada en el CCH Vallejo y termino con las razones por las cuales es importante enseñar la argumentación a los estudiantes de bachillerato.
An attempt to replace orthodox sacraments with new Soviet rituals in the 1960–80s: a case study of Perm region
Authors: Sapsay Andrey
Published: June 2024

This article deals with introducing new civil ritualism by the Soviet authorities. The new Soviet holidays and rituals were to become an alternative to the Orthodox sacraments and a form of struggle against religion. The author analyzes quantitative indicators of both non-religious rituals (ceremonial registration of marriage and birth, civil memorial service) and Orthodox sacraments (baptism, wedding, funeral rite) performed by the population of the Perm region in the 1960s - early 1980s. It has been established that as a result of the adopted laws, the involvement of administrative resources, public figures and widespread atheistic propaganda, they gradually managed to introduce new non-religious rituals in the Perm region in the period from 1964 to 1983. Within the framework of the study, various forms and methods used to introduce civil rituals and to reduce the Orthodox sacraments are for the first time investigated on the basis of archival sources and literature. They are sociological research, educational work in schools, the persecution of the clergy and believers, etc. It is noted that local authorities themselves, trying to comply with the requirements of the legislation on cults, admitted the facts of its gross violation. Nevertheless, the main goal of the anti-church policy - the replacement of the Orthodox sacraments and rites with the new Soviet rituals - was not fulfilled; the number of Orthodox sacraments and rites practically did not decrease. Moreover, in the late 1970s, some weakening of control over the activities of church organizations and increase in the number of religious rituals was observed everywhere. It was facilitated by a more liberal attitude of the local authorities towards the Russian Orthodox Church, strengthening of educational activities of the clergy, and the population's commitment to Orthodox traditions. The statistical data presented in the work allow the author to conclude that the introduction of new civil rituals could not oust the sacraments and rites performed in the church from the life of the Orthodox population.
The origin and activity of Yelets autocephaly in Orel diocese in the early 1920s: a history of resistance to the Renovationist Schism in the Russian Orthodox Church
Authors: Balyko Timofey
Published: June 2024

The article discusses the process of creation in 1922-1923. Yelets autocephaly, whose leaders - as well as the leaders of the Petrograd, Ufa, Belev and Nizhny Tagil autocephalies - refused to recognize the authority of the renovationist "Supreme Church Administration" and continued to remain faithful to Patriarch Tikhon. The author of the study not only restores the history of the emergence and activity of the autocephalous Yelets diocesan administration in the Orel diocese that joined the Renovationists, but also reveals the features of the creation of the Yelets autocephaly in comparison with similar processes in other regions listed above. One of these features can be called the fact that in Yelets the creation of autocephaly, which began two weeks after the Renovationist coup in Moscow - at the end of May 1922, was already carried out by mid-September, and without the direct participation of the bishops who were imprisoned - by forces active parish clergy, who transferred the administration of autocephaly to Bishop Nikolai (Nikolsky) of Yelets, who was released in October 1922. The history of the Yelets diocesan administration went beyond the Oryol diocese and by 1923 reached the level of the highest executive authorities of the Soviet state. Yelets autocephaly was the only autocephaly considered in the article, created without the participation of bishops, by the forces of the clergy and laity - already in September 1922. The study of the example of self-organization of a part of the church people in Yelets during the schism of the 1920s, the study of the significance of church documents of 1917-1922 supporting the self-government of parishes and dioceses, acquires additional relevance for developing a strategy to minimize the spread of regional church-political unrest.
Study on signature of hair for identification of two major ethnic groups
Authors: Nath Sabyasachi , Banik Debasish , Pratihari HK , Chaudhuri PS
Published: June 2024

Studies on hair have important forensic significance since hair is the most common type of physical evidence detected in crime like murder, rape, burglary even poaching related cases and other ways also. The examination of hair helps to establish the origin, race, sex, age etc. and also to link evidence in different crime cases. In the present study, an effort has been made to create a database of two ethnic groups considering various morphometric parameters of scalp hair using light microscopy, SEM as well as conventional methods. The database of two major groups (Caucasian and Mongolian) of the state Tripura, North-Eastern region of India, will help the researchers, forensic experts, biologists, dermatologists and legal experts working in different fields.
Understory plant species diversity of Asalem’s forests, northern Iran
Authors: Yazdanshenas Habib , Kalagar Mehdi , Toularoud Mehdi Moradipour
Published: June 2024

The diversity of plants in forests understory is important from different perspectives. Thus, present research was carried out to find the chorology, origin and diversity of the understory plants species in Asalem's forests, northern Iran. Basic studies were conducted on the geographic characteristics of the region. The direct visiting forests method were selected for investigation of tree and understory plants species (herbs) which lasted of the year 2017 to 2018. Sampling of understory vegetation were done, recorded and identified based on available scientific references. The results showed that there are more than 152 species belonging to 124 genera and 61 families existed in forest understory. The largest families were Asteraceae, Rosaceae, Poaceae and Apiaceae with 17, 13, 11 and 10 species, respectively. Investigation of the geographical distribution of plant species indicated that there is a composition of Europe–Siberian, Iran-Turan, Mediterranean (and Polyregional and cosmo) plant elements. Plant life forms by Raunkiaer method showed that phanerophytes with 28 % and Chameophytes = Therophytes with 26 % are the most frequent life forms in this area. Also, plant diversity was higher in areas with sparse tree cover, but in degraded areas or areas with high tree vegetation understory plants diversity was low.
The No-Self Thesis: counterarguments from abnormal psychology
Authors: Berisha Elma
Published: June 2024

The no-self thesis is said to originate in David Hume’s1 “bundle theory of self,” questioning the human self as a mere bundle of fleeting perceptions without ontological reality. In contemporary discourse, the self is sandwiched between top-down and bottom-up reductionisms: those with biological and cognitive arguments that reduce the self to a lower, ontological level, on the one hand, and those who hold cultural-linguistic constructionist positions, on the other hand, reducing the self to a higher level. In both cases, self reductionism is a prelude to complete self elimination. On these conceptions, what we call “self” may be nothing other than an unintended by-product of brain processes. Nevertheless, a cursory literature review suggests that the self firmly remains indispensable to almost every contemporary field of inquiry. Research and publications on the topic of the self have increased significantly in recent years across a number of disciplines. This paper aims to offer insights into the question of the self and its realities from the perspective of Abnormal Psychology. Although conventional Psychiatry is not directly invested in exploring the concept of “self” per se, the elaborate symptomatology and in-depth treatment of disorders in practice is indispensably linked to patients’ sense of self. In fact, a wide range of psychological and psychiatric disorders nowadays are increasingly being formally re-defined in terms of the “self”. Above and beyond to what has come to be known as the “new disorders of the self”, relevance of the self applies to classic categories of dissociation, autism, schizophrenia, personality disorders, and more. The pathological alternatives to a healthy sense of self are abound, and no effective psychotherapeutic intervention can be imagined without the concept of self.
Guidance on Conversations About Race and Racism in Pediatric Clinical Settings
Authors: Clark Shawnese , Cohen Alyssa , Welch Sarah B. , Bate Aleha , Anderson Ashaunta T. , Chomilo Nathan , Dougé Jacqueline , Durkee Myles , Iruka Iheoma U. , Jindal Monique , Jones Shawn C.T. , Li Angie , Arshad Aisha , Heard-Garris Nia
Published: June 2024

OBJECTIVE

To develop guidance for pediatric clinicians on how to discuss race and racism in pediatric clinical settings.

METHODS

We conducted a modified Delphi study from 2021 to 2022 with a panel of pediatric clinicians, psychologists, parents, and adolescents with expertise in racism and child health through scholarship or lived experience. Panelists responded to an initial survey with open-ended questions about how to talk to youth about race and racism. We coded the responses using qualitative methods and presented them back to the panelists. In iterative surveys, panelists reached a consensus on which themes were most important for the conversation.

RESULTS

A total of 29 of 33 panelists completed the surveys and a consensus was reached about the concepts pediatric clinicians should consider before, during, and after conversations about race and racism and impediments clinicians may face while having these discussions. Panelists agreed that it was within the pediatric clinician’s role to have these conversations. An overarching theme was the importance of having background knowledge about the systemic nature of racism. Panelists agreed that being active listeners, learning from patients, and addressing intersectionality were important for pediatric clinicians during conversations. Panelists also agreed that short- and long-term benefits may result from these conversations; however, harm could be done if pediatric clinicians do not have adequate training to conduct the conversations.

CONCLUSIONS

These principles can help guide conversations about race and racism in the pediatric clinical setting, equipping clinicians with tools to offer care that acknowledges and addresses the racism many of their patients face.
Specializované mapy - Pěší dostupnost v Ostravě a Mostě
Authors:   University of Ostrava, Department of Human Geography and Regional Development
Published: June 2024

Tyto specializované mapy s odborným obsahem byly vypracovány jako výstup projektu TAČR: Implementace walkability jako nástroje podpory udržitelné mobility českých měst (číslo grantu CK04000226).
Is decreasing problematic mobile phone use a pathway for alleviating adolescent depression and sleep disorders? A randomized controlled trial testing the effectiveness of an eight-session mindfulness-based intervention
Authors: Liu Qingqi , Yang Xiujuan , Zhang Chenyan , Xiong Jie
Published: June 2024

Objective

The present study aimed to evaluate the efficacy of a mindfulness-based cognitive therapy (MBCT) intervention in reducing problematic mobile phone use, depression, and sleep disorders among adolescents. Additionally, it sought to investigate whether the decrease in problematic mobile phone use acted as a mediator in the relationship between the MBCT intervention and adolescent depression and sleep disorders.

Methods

In a randomized controlled trial, a total of 104 adolescents were randomly assigned to the mindfulness group (n = 52) or the wait-list control group (n = 52). The mindfulness group students completed eight 45-min sessions of mindfulness training in four weeks. The outcomes were measured at baseline, postintervention, and at the 2-month follow-up.

Results

Compared with the control group, the mindfulness group had significantly greater levels of mindfulness and lower levels of problematic mobile phone use, depression, and sleep disorders postintervention. The intervention effects were maintained at the 2-month follow-up. In addition, decreased problematic mobile phone use significantly mediated the association between the MBCT intervention and decreased depression and decreased sleep disorders.

Conclusion

The findings suggest that MBCT could improve adolescent depression and sleep disorders and that decreasing problematic mobile phone use is an effective pathway accounting for the MBCT intervention effect on adolescent depression and sleep disorders.
Próba demitologizacji. O Jak zostałem pisarzem Andrzeja Stasiuka
Authors:   Uniwersytet Śląski, Hanik Katarzyna
Published: June 2024

The aim of this article is to show that the strategy of demythologizing one’s own experiences applied by Stasiuk in his autobiography entitled Jak zostałem pisarzem constitutes a ‘play on taboos’. To this end, the author analyses the narrative strategies manifested within the writer’s autobiographical statements, especially those that trivialize and demythologize events that were constituting a kind of ‘generational experience’ for Stasiuk’s generation. Such a strategy of portraying oneself proves to be a kind of ‘play on taboos’, which in this case can be defined as a certain imperative of portraying ‘the experience of basic military service’ and ‘the experience of underground activity’ in People's Republic of Poland.
Johannes Sturm (1507-1589): pedagogo e humanista
Authors: Cazavechia William Robson , Vieira Paulo Henrique , Arnaut de Toledo Cezar de Alencar
Published: June 2024

Johannes Sturm (1507-1589) foi um educador protestante do século XVI que se tornou muito respeitado por seu trabalho enquanto professor, pedagogo e diretor do gymnasium de Estraburgo na França. Seu plano para o gymnasium da cidade, publicado em 1538, foi tão notável que o colégio atraiu alunos de toda a Europa protestante. Scholae Lavingnae, escrito em 1565, foi outro projeto de Sturm, desta vez, para a cidade de Lauingen, na Alemanha, e traz detalhes sobre o currículo e o método proposto por ele. O texto aqui utilizado na análise foi uma tradução do latim para o inglês que se encontra no livro: Johannes Sturm on education de 1995. A pesquisa foi desenvolvida a partir de levantamento bibliográfico orientado pela análise historiográfica na área da pesquisa em Educação.
A Tessalônica de Paulo: arqueologia e história
Authors: José Ademar Kaefer
Published: June 2024

Tessalônica era desde o seu começo uma cidade estratégica, tanto para os interesses gregos, quanto para os romanos. Chegou, inclusive, a ser sede do imperador romano Maximiano Galério, período em que muito das grandes obras foram realizadas na cidade. Foi nesta cidade greco-romana que Paulo e seus companheiros organizaram uma das primeiras e mais importantes comunidades cristãs. Nosso objetivo é, através de referenciais teóricos e da análise in situ dos sítios arqueológicos, apresentar os principais remanescentes arqueológicos e históricos da antiga Tessalônica. Esta meta vai ajudar a encorpar a compreensão das duas cartas aos tessalonicenses atribuídas a Paulo, bem como a importância que a cidade adquiriu nos primórdios do cristianismo, tendo como principal expressão o martírio de São Demétrio.