bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pandemi Covid-19 Terhadap Minat Penggunaan Layanan Mobile Banking
Authors: Sudjali Iwan Purwanto , Akbar Muhammad Alwi , Rosa Edy Safni
Published: September 2023

Currently, Indonesia is experiencing a national disaster in the form of the Covid-19 which is a virus with a very fast transmission rate.pandemic Covid-19 is allegedly not only attacking health but also affecting the global economy. In the end, many people use digital transactions such as Mobile banking during this pandemic. Mobile Bankingaservice provided by banks to facilitate their customers in transacting anywhere and anytime. Mobile banking useful for customers in carrying out government policies of stay at home and physical distancing to break the chain of virus spread during the covid 19

This study aims to determine the effect of Stay at home (X1) and Physical distancing (X2) on interest in using Mobile banking (Y) during the Covid-19. The method used in this study is multiple linear regression analysis, this is an analysis that describes the form of influence between one or more variables with other variables. The type of data used in this study is a secondary data source that was processed from 100 respondents from customers of Bank Central Asia Tbk Bogor Main Branch Office.

Based on the results of data processing, there is a significant positive effect between stay at home on interest in using Mobile banking services at PT Bank Central Asia Tbk Bogor Main Office, there is a significant positive effect between physical distancing on interest in using Mobile banking services at PT Bank Central Asia Tbk Bogor main office. There is a joint influence of stay at home and physical distancing on the Interest in Using Mobile banking Services PT Bank Central Asia Tbk Bogor Main Office.

Keywords: Stay at home, physical distancing, intention, and Mobile Banking
Boundary Treatment for the Subsonic/Alfvénic Inner Boundary at 2.5 R
⊙ in a Time-dependent 3D Magnetohydrodynamics Solar Wind Simulation Model
Authors: Hayashi Keiji , Wu Chin-Chun , Liou Kan
Published: September 2023

A new magnetohydrodynamics (MHD) simulation model of the global solar corona and solar wind is presented. The model covers the range of heliocentric distance from 2.5 solar radii, so that coronal mass ejections at the earliest phase near the Sun can be treated in the future. This model is constructed by introducing a characteristics-based boundary treatment to an existing heliosphere 3D MHD model. In tailoring a set of characteristic equations for this new model, we assume that the coronal magnetic field is open to interplanetary space and that the solar coronal plasma is flowing outward everywhere at 2.5 solar radii. The characteristic equations for the subsonic/Alfvénic inner boundary surface are satisfied by altering the plasma density and/or temperature to maintain a polytropic relationship. In this article, the details of the characteristics-based boundary treatment for the middle of the corona (named CharM) are provided. The quasi-steady states of the solar wind derived from simulations with various choices of a parameter in the boundary treatments are compared and examined. Although further improvements are needed, we apply the new boundary treatment to simulations for three Carrington rotation periods from the minimum to maximum phase of the solar activity cycle, and show that an optimal choice yields a reasonable quasi-steady state of the transonic/Alfvénic solar wind matching the specified subsonic/Alfvénic plasma speed at 2.5 R
⊙.
Management Heart Failure with Preserved Ejection Fraction: A Mini Review
Authors: Laksono Sidhi , Franata Robby
Published: September 2023

BACKGROUND: Heart failure (HF) is a complex clinical syndrome that results when heart’s ability to contract or fill is impaired structurally or functionally. Current guideline has been classified HF according to level of left ventricular ejection fraction (EF). 1) Heart failure with reduced ejection fraction (HRrEF): EF ≤ 40%; 2) Heart failure with mildy ejection fraction (HRmrEF): EF 41 - 49%; 3) Heart failure with preserved ejection fraction (HRpEF): EF ≥50%.
AIM: We aimed to analyse the management of heart failure with preserved ejection fraction.
METHODS: We conducted a literature search of relevant articles in various databases (Pubmed & Google Scholar). Articles to include in the review was based on agreement of the authors.
RESULTS: Heart failure with preserved ejection fraction (HFpEF) accounts for 50% of all heart failure cases. HFpEF remains a challenging condition to diagnose given its unclear and often heterogenous etiology with numerous clinical mimics and complex systemic pathophysiology.
CONCLUSION: Additionally, effective treatment modalities are limited with numerous negative clinical trials over the past few decades. In this review, we updated the last knowledge of management HFpEF by reviewing recent guideline and studies.
On a taxonomic feature that has been overestimated in classification practice: an integrative taxonomic revision of Stephoblemmus Saussure, 1877 based on morphology and molecular phylogeny (Orthoptera: Grylloidea; Gryllidae; Gryllinae)
Authors: Zheng Yan-Na , Gu Jun-Jie , He Zhu-Qing , Huang Huateng , Ma Li-Bin
Published: September 2023

The hemispherical head is prevalent in Gryllinae crickets, so the rare crickets that have a unique form of head will be extremely unusual. In previous studies, this special feature can be one of the important features to distinguish and identify these crickets. But does this particular head shape truly reflect a clear-cut taxonomic relationship? The species of the genus Loxoblemmus have a typical truncate head; species of the genus Stephoblemmus have a more exaggerated truncate head, with the frontal end even extending into a lamellar. The genus Mitius is relatively unusual in that species of this genus have both globose or truncate heads. How are these species related? Does the cephalic shape perfectly reflect the natural classification of these species? Based on these questions, the study applied species definition and morphological classification to explore the intergeneric and intrageneric species relationships of the genera Mitius, Stephoblemmus, and Loxoblemmus, and derived the following main conclusions: (1) Mitius and Stephoblemmus are related and distinct from Loxoblemmus; (2) Mitius species bear two types of frons (truncated and rounded), but this feature disallows them to be classified as natural groups; (3) one genus synonym and three species synonyms are raised (Mitius Gorochov, 1985 syn. n., Mitius splendens (Shiraki, 1930) syn. n., Mitius eryuanensis Yuan, Xie & Liu, 2021 syn. n. and Mitius brevipennis Yuan, Ma & Gu, 2022 syn. n.), and seven new status combinations are proposed (Stephoblemmus blennus (Saussure, 1877) comb. n., Stephoblemmus castaneus (Chopard, 1937) comb. n., Stephoblemmus enatus Gorochov, 1994 comb. n., Stephoblemmus flavipes (Chopard, 1928) comb. n., Stephoblemmus minor (Shiraki, 1911) comb. n., Stephoblemmus minutulus (Yang & Yang, 1995) comb. n. and Stephoblemmus vaturu (Otte & Cowper, 2007) comb. n.). The studies indicated that frons shapes that appear to be significantly different might not always reflect the correct Gryllinae species relationships and a combination of more taxonomic features and taxonomic techniques is needed often to reveal the true taxonomic relationships.
A new class of multiple nonlocal problems with two parameters and variable-order fractional $ p(\cdot) $-Laplacian
Authors: Hamdani Mohamed Karim , Mbarki Lamine , Allaoui Mostafa
Published: September 2023

In the present manuscript, we focus on a novel tri-nonlocal Kirchhoff problem, which involves the $ p(x) $-fractional Laplacian equations of variable order. The problem is stated as follows:

   \begin{document}$ \begin{eqnarray*} \left\{ \begin{array}{ll} M\Big(\sigma_{p(x, y)}(u)\Big)(-\Delta)^{s(\cdot)}_{p(\cdot)}u(x) = \lambda |u|^{q(x)-2}u\left(\int_{\Omega}\frac{1}{q(x)} |u|^{q(x)}dx \right)^{k_1}+\beta|u|^{r(x)-2}u\left(\int_{\Omega}\frac{1}{r(x)} |u|^{r(x)}dx \right)^{k_2} \quad \mbox{in }\Omega, \\ \ u = 0 \quad \mbox{on }\partial\Omega, \end{array} \right. \end{eqnarray*} $\end{document}

where the nonlocal term is defined as

   \begin{document}$ \sigma_{p(x, y)}(u) = \int_{\Omega\times \Omega}\frac{1}{p(x, y)}\frac{|u(x)-u(y)|^{p(x, y)}}{|x-y|^{N+s(x, y)p(x, y)}} \, dx\, dy. $\end{document}

Here, $ \Omega\subset\mathbb{R}^{N} $ represents a bounded smooth domain with at least $ N\geq2 $. The function $ M(s) $ is given by $ M(s) = a - bs^\gamma $, where $ a\geq 0 $, $ b > 0 $, and $ \gamma > 0 $. The parameters $ k_1 $, $ k_2 $, $ \lambda $ and $ \beta $ are real parameters, while the variables $ p(x) $, $ s(\cdot) $, $ q(x) $, and $ r(x) $ are continuous and can change with respect to $ x $. To tackle this problem, we employ some new methods and variational approaches along with two specific methods, namely the Fountain theorem and the symmetric Mountain Pass theorem. By utilizing these techniques, we establish the existence and multiplicity of solutions for this problem separately in two distinct cases: when $ a > 0 $ and when $ a = 0 $. To the best of our knowledge, these results are the first contributions to research on the variable-order $ p(x) $-fractional Laplacian operator.
A novel design and simulation of a mechanical coordinate based photovoltaic solar tracking system
Authors: Rustemli Sabir , İlcihan Zeki , Sahin Gökhan , van Sark Wilfried G. J. H. M.
Published: September 2023

Various methods have been developed to increase electrical energy production gains in photovoltaic (PV) systems. These can be classified as solar tracking systems, cooling systems and methods of reducing the effect of shading. In order to maximise the PV energy yield, the PV systems must follow the sun. In this study, the effect of solar tracking systems on the energy yield gains of PV systems is investigated, and various types of solar tracking systems are discussed in detail. To ensure accuracte tracking of the postion of the sun, a new, low-cost, system has been developed that employs a global positioning system (GPS) module, compass and accelerometer. With this necessary angle information a dual-axis coordinate-based solar tracking system was designed using the Arduino Mega 2560 microcontroler with home-built control software. The system is validated by comparing it to a fixed angle system and an energy yield gain of 33–38% is found.
Boundary value problems of hybrid fractional integro-differential systems involving the conformable fractional derivative
Authors: Taier Ala Eddine , Wu Ranchao , Iqbal Naveed
Published: September 2023

In this paper, we study a boundary value problem for the hybrid fractional integro-differential system involving the conformable fractional derivative. We first discuss the existence of solutions using the Krasnoselskii fixed point theorem. The second result will be the existence and uniqueness of solution and we obtain it using the Banach fixed point theorem. Finally, we end our work with an example to illustrate our results.
Mathematical investigation of normal and abnormal wound healing dynamics: local and non-local models
Authors: Adebayo O. E. , Urcun S. , Rolin G. , Bordas S. P. A. , Trucu D. , Eftimie R.
Published: September 2023

The movement of cells during (normal and abnormal) wound healing is the result of biomechanical interactions that combine cell responses with growth factors as well as cell-cell and cell-matrix interactions (adhesion and remodelling). It is known that cells can communicate and interact locally and non-locally with other cells inside the tissues through mechanical forces that act locally and at a distance, as well as through long non-conventional cell protrusions. In this study, we consider a non-local partial differential equation model for the interactions between fibroblasts, macrophages and the extracellular matrix (ECM) via a growth factor (TGF-$ \beta $) in the context of wound healing. For the non-local interactions, we consider two types of kernels (i.e., a Gaussian kernel and a cone-shaped kernel), two types of cell-ECM adhesion functions (i.e., adhesion only to higher-density ECM vs. adhesion to higher-/lower-density ECM) and two types of cell proliferation terms (i.e., with and without decay due to overcrowding). We investigate numerically the dynamics of this non-local model, as well as the dynamics of the localised versions of this model (i.e., those obtained when the cell perception radius decreases to 0). The results suggest the following: (ⅰ) local models explain normal wound healing and non-local models could also explain abnormal wound healing (although the results are parameter-dependent); (ⅱ) the models can explain two types of wound healing, i.e., by primary intention, when the wound margins come together from the side, and by secondary intention when the wound heals from the bottom up.
Dynamics and optimal control of a stochastic Zika virus model with spatial diffusion
Authors: Shao Minna , Zhao Hongyong
Published: September 2023

Zika is an infectious disease with multiple transmission routes, which is related to severe congenital disabilities, especially microcephaly, and has attracted worldwide concern. This paper aims to study the dynamic behavior and optimal control of the disease. First, we establish a stochastic reaction-diffusion model (SRDM) for Zika virus, including human-mosquito transmission, human-human sexual transmission, and vertical transmission of mosquitoes, and prove the existence, uniqueness, and boundedness of the global positive solution of the model. Then, we discuss the sufficient conditions for disease extinction and the existence of a stationary distribution of positive solutions. After that, three controls, i.e. personal protection, treatment of infected persons, and insecticides for spraying mosquitoes, are incorporated into the model and an optimal control problem of Zika is formulated to minimize the number of infected people, mosquitoes, and control cost. Finally, some numerical simulations are provided to explain and supplement the theoretical results obtained.
Renal trauma during a rugby tackle
Authors: Pothiawala Sohil , Schroll Rebecca
Published: September 2023

Rugby-related renal trauma is rare and identification of a young patient with renal trauma secondary to sports who requires observation versus further radiological evaluation in the emergency department (ED) poses a diagnostic challenge. We report a case of a 16-year-old girl who presented to the ED with abdominal pain after being tackled during a game of rugby. Examination revealed tenderness over the right lateral lower ribs and right flank. Blood tests were normal and bedside ultrasound did not show any free intraperitoneal fluid. Urinalysis showed gross hematuria. She was pain-free after analgesia but had a syncopal episode in the ED. A computed tomography (CT) scan of the abdomen and pelvis showed a complex right lower pole renal laceration and she was admitted to the Intensive Care Unit. She remained stable and was discharged. Assessment with urinalysis, hematocrit, and creatinine is required during the evaluation of a patient with suspected renal trauma. CT scan is the imaging modality for the diagnosis and grading of renal injury. Conservative treatment is the mainstay of therapy, but some patients require angioembolization of surgical intervention. Patients must discuss with their physician regarding the optimal timing of return to rugby. Rugby-related renal trauma is rare and poses a challenge for emergency physicians regarding their evaluation and management in the ED. AAST-OIS grading of renal trauma on CT imaging helps guide appropriate management decisions.
Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia
Authors: Edris Mashaer Taha , Merghani Maye Mohammad , Gafar Shaza Salih , Asmali Ahmed Mohamed , Yasin Elrashed B. , Alserihi Raed , Alkhatabi Heba , Qutob Haitham MH. , Qahwaji Rowaid , Ali Elshazali Widaa
Published: September 2023

Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, and epigenetic processes. It is encoded by the MTRR gene, which garnered a lot of attention in current medical genetics research. This study was conducted to study the association between MTRR (A66G) polymorphism and the risk of developing acute lymphoblastic leukemia among Sudanese patients. Materials and Methods. This is a case-control study in which 150 patients with acute lymphoblastic leukemia (ALL) and 150 healthy participants as a control group were enrolled. DNA was extracted and analyzed for the MTRR (A66G) polymorphism using the real-time polymerase chain reaction. Results. Based on flow cytometry results, B-ALL was more common (79%) than T-ALL (21%). The comparison of hematological parameters in acute lymphoblastic leukemia subtypes showed a statistically significant high mean total white blood count (P=0.000) and mean blast percentage (P=0.050) in patients with T-ALL. The molecular analysis showed that the incidence of the MTRR homozygous genotypes AA and GG were higher in the patients (44% and 9.3%, respectively) compared to the control group (40% and 6.7%, respectively). In comparison, the heterozygous genotype AG was lower in the patients (46.7%) than in the control group (53.3%). However, the association between the polymorphism and acute lymphoblastic leukemia risk was not statistically significant (OR: 1.179, 95% CI 0.7459-1.865, P=0.445). Conclusions. This study concluded that MTRR A66G polymorphism was not associated with the risk of acute lymphoblastic leukemia among the Sudanese population.
Differences in nutritional status of patients with chronic obstructive pulmonary disease between Mediterranean and non-Mediterranean regions in Croatia
Authors: Muršić Davorka , Jalušić Glunčić Tajana , Ostojić Jelena , Škrinjarić Cincar Sanda , Bulat Kardum Ljiljana , Dokoza Martina , Karamarković Lazarušić Nataša , Bešić Erim , Samaržija Miroslav , Vukić Dugac Andrea
Published: September 2023

The nutritional status of patients with chronic obstructive pulmonary disease (COPD) is a significant factor that influences the prognosis of the disease. This observational study aimed to analyse the nutritional status of COPD patients and assess the associations between nutritional status, disease severity, and exercise capacity in four different regions of Croatia. In this multicentre study, 534 COPD patients were recruited and evaluated concerning fat-free mass (FFM), fat-free mass index (FFMI), skeletal muscle mass index (SMMI), phase angle (PhA), pulmonary function tests, and the 6-minute walk test (6MWT). There were 325 (60.9%) male and 209 (39.1%) female patients with a mean age of 66.7±8.4 years. Most patients (73.2%) exhibited a moderate to severely abnormal obstructive pattern and had a reduced 6MWT distance (396.5±110.8 m). Among the participants, 32.8% were overweight and 22.3% were obese, and they had satisfactory values for nutritional status variables (FFM, FFMI, SMMI, PhA). There were no statistical differences between the centres in terms of nutritional status variables. There was a significantly positive correlation of FEV1 with BMI (r=0.148, p=0.001), PhA (r=0.256, p=0.00), FFM (r=0.365, p=0.00), and SMMI (r=0.238, p=0.00). However, there was no significant correlation of the 6MWT with BMI (r=-0.049, p=0.254), FFM (r=0.065, p=0.133), and SMMI (r=-0.007, p=0.867). The data analysis demonstrated that our patients were not underweight and that there was no significant difference between the centres in terms of BMI, FFM, FFMI, SMMI, and PhA. This lack of significant difference was observed even though one of the regions studied was Mediterranean.
Delirium as an Adverse Reaction to BNT162b2 mRNA Vaccine from Pfizer Inc., and BioNTech
Authors: Galan Lilia M. Sierra , Shaooli Raquel Cohen
Published: September 2023

The spike-protein severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine has developed different adverse reactions. Still, delirium has not been reported in a low-risk patient, and it is important to consider it and recognize it as a possibility in all severity risk patients. We present a 76-year-old male patient who developed delirium after receiving the second dose of the BNT162b2 mRNA vaccine from Pfizer Inc. and BioNTech®. We theorize about the potential pathophysiology mechanisms involved.
The expression level of aspartate beta-hydroxylase (ASPH) and clinical importance in acute myeloid leukemia
Authors: Said Fadwa , El Ghammaz Amro M. , Shazly Mohamed A. , Azzazi Mohamed O.
Published: September 2023

Background

Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by clonal expansion of myeloid progenitors in the bone marrow and peripheral blood. Aspartate β-hydroxylase (ASPH) is a membrane protein that promotes cellular motion. Recent studies have revealed that ASPH is an indicator of carcinoma in humans and is highly expressed in AML.

Patients and methods

The study included 30 AML patients diagnosed and classified by complete blood count with differential, bone marrow study, flow cytometric, cytogenetic, and molecular studies, and 10 normal participants of the same age group. The serum level of ASPH was measured in both cases and controls by enzyme-linked immunosorbent assay.

Results

The level of ASPH was significantly higher in patients than in controls (P < 0.001). Patients with mutant FLT3 had higher serum ASPH compared with those with wild FLT3 with a trend toward statistical significance (P = 0.074). Other clinical and laboratory variables had no relationship with ASPH levels in the blood.

Conclusion

This study detected a significant increase in ASPH levels in the blood of AML patients more than the controls, shedding the light on the role of ASPH in AML genesis and paving the way for the development of new medications that block ASPH's leukemogenesis effect in the future.
The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus
Authors: Mohamed Enas M. , Kareem Heba S. , Zahran Shaimaa M. , El Sissy Maha H.
Published: September 2023

Objectives

Patients with type-2 diabetes mellitus (T2DM) have an increased incidence of adverse cardiovascular events secondary to endothelial dysfunction, hypercoagulability, and decreased fibrinolysis. This study aimed to evaluate protein-C and protein-S activities and carotid intima-media thickness (CIMT) in patients with T2DM who were treated with statins and/or angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-II receptor blockade (ARB).

Basic methods

One hundred and twenty patients with T2DM participating in the study were classified into groups based on their use of statins and ACEI/ARBs. Protein-C and protein-S activity and CIMT were compared.

Main results

Patients treated with both statins and ACEI/ARBs showed the highest levels of protein-C and protein-S activity (P < 0.001). This was followed by patients on statins alone and patients on ACEI/ARBs alone. Patients who were not on statin or ACEI/ARB therapy had the lowest levels of protein-C and protein-S activity. Moreover, we identified significant correlations between protein-C and protein-S activities and CIMT with hemoglobin A1c, cholesterol, and low-density lipoprotein.

Conclusion

ACEI/ARBs and statins have a critical impact on the hypercoagulable state characteristic of T2DM, potentially via increased levels of protein-C and protein-S activity. ACEI/ARBs also limited CIMT, an important surrogate marker for atherosclerosis.
Evaluation of a Fixed-dose Combination of Mebeverine and Chlordiazepoxide for Irritable Bowel Syndrome
Authors: Pratap Nitesh , Goyal Omesh , Jagtap Sumeet , Goswami Bhabadev , Kalita Partha Pratim
Published: September 2023

Background:

To assess the effectiveness and safety of a fixed-dose combination (FDC) of mebeverine hydrochloride 135 mg and chlordiazepoxide 5 mg in the management of irritable bowel syndrome (IBS) in Indian patients.

Methods:

This was an 8-week, prospective, open-label, observational study. Patients (n = 60, age: 18–60 years) newly diagnosed with IBS and having anxiety symptoms (score ≥18 on Hamilton Anxiety Rating Scale [HAM-A]), who were prescribed the study drug as a part of routine practice were included.

Results:

All 60 enrolled patients completed the study. Patients’ mean standard deviation (SD) age was 37.45 (11.00) years; most were male (73.33%). The mean (SD) IBS-symptoms severity scale (IBS-SSS) score at baseline was 182.72 (84.39) indicating moderate symptom severity; the mean change at week 8 was 85.50 (82.69), P < 0.0001 (primary endpoint), and at week 4 was 64.70 (58.44), P < 0.0001. The mean (SD) IBS-36 score was 78.33 (41.87) at baseline and decreased at week 8 by 45.88 (34.92), P < 0.0001. At week 8, majority of patients achieved a ≥50-point improvement in IBS-SSS score (73.33%), and a ≥10-point improvement in IBS-36 scores (88.33%). The mean (SD) HAM-A total score was 26.97 (6.72) at baseline and decreased to 10.45 (8.99) at week 8, P < 0.0001. Three adverse drug reactions unlikely to be related to study drug were reported in two patients (nausea n = 1, headache n = 2). Good tolerability to study drug was reported by all patients and investigators at week 8.

Conclusion:

The FDC of mebeverine hydrochloride and chlordiazepoxide was effective in the treatment of IBS and was well tolerated.
Proton-Pump Inhibitor Therapy in Patients with Erosive Esophagitis: A Real-World Scenario
Authors: Jain Mayank
Published: September 2023

Background:

Gastroesophageal reflux disease (GERD) has three classical phenotypes, namely erosive esophagitis (EE), nonerosive reflux disease, and Barrett’s esophagus. Patients with GERD are managed with lifestyle changes, dietary interventions, and proton-pump inhibitors (PPI).

Aim:

To determine the patterns of PPI use in patients with documented EE.

Methods:

This prospective study recruited all patients with symptoms of GERD (heartburn and/or regurgitation with or without chest pain) and documented significant reflux esophagitis (Los Angeles grading LA-B or beyond on endoscopy). Lifestyle and dietary changes were initiated and all patients were prescribed twice daily PPI for 8 weeks. PPI was tapered as the requirement beyond 8 weeks. Follow-up was done at weeks 8, 12, and 24. The outcomes analysed included number of patients where complete PPI withdrawal was possible at week 24 and determinants of continued PPI use at 24 weeks of therapy. Statistical analysis was performed using Chi-square test, Mann–Whitney U-test, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio. P < 0.05 was considered statistically significant.

Results:

The study cohort included 53 patients-42 with reflux esophagitis LA-B and 11 with reflux esophagitis LA-C (median age 46 years [22–77 years]; 28 [52.3%] males). There was significant difference in consumption pattern of PPI between week 12 and 24 (P = 0.008). At week 12, 15.1% were off PPI and 67% required intermittent dosing. At week 24, 45.3% of cases were off PPI therapy and 43.4% required intermittent dosing. Only 11.3% patients continued drug use at once a day dosing. Lower body mass index (BMI) (P 0.01) and age (P 0.01) were linked with complete PPI withdrawal at week 24.

Conclusion:

The present study highlights that PPI withdrawal is possible in 15.1% and 45.3% cases with EE after week 12 and week 24 of therapy, respectively. Lower BMI and age are likely to be associated with PPI withdrawal at week 24.
Role of Ayurveda in the Management of Female Infertility Due to Poly Cystic Ovarian Syndrome with a History of Bilateral Ectopic Pregnancy, Right Sided Salpingectomy, and Left Sided Hydrosalpinx
Authors: Anvekar Bharathi Dattaram
Published: September 2023

Poly cystic ovarian syndrome (PCOS), fallopian tubal blockage, and repeated spontaneous abortions are some of the causes of female infertility. Hormonal treatment or drilling of ovaries, microsurgery of fallopian tubes, andin vitrofertilization are the accepted standard treatment procedures. In Ayurveda, the condition is correlated with named as Vandhyatva. Acharyas have described the causes as Garbhasrava, Beeja Dushti, and Mithya Ahara Vihara. Here, we report a case of infertility secondary to PCOS with a surgical history of emergency laparoscopic right-sided salpingectomy for ectopic pregnancy. Methotrixate administration for left side ectopic pregnancy, consequently for second time and left-sided hydrosalpinx. The case was treated as per the classical reference which includes virechana karma, kala basthi, marsha nasya karma, and Uttara basthi karma. Music therapy, rasayana chikitsa, and yoga were incorporated as adjuvant therapy to achieve shuddha garbha sambhava samagri (pure factors of fertilization and conception). Adopted treatment plan has given good result with successful intrauterine pregnancy and birth of healthy female baby through cesarean section.
A Cross-Sectional Study to Assess Resilience and Perceived Social Support among Cancer Patients
Authors: Rani Ruchika , Chadha Lisa , Gupta Sweety
Published: September 2023

Introduction:

Cancer is one of the health emergencies across the globe causing the highest mortality rates. Its dimensions are far beyond the physical illness as it causes a long-lasting psychological impact on the patient as well as family mental health due to its poor prognosis, low survival rates, and substantial distress due to its treatment modalities. This study aims to assess the level of resilience and perceived social support among cancer patients.

Subjects and Methods:

A cross-sectional survey was conducted from January 2020 to April 2020. A total of 405 cancer patients were enrolled in this research study who were attending the oncology outpatient department at our institute. The data was collected through planned interviews using Connor–Davidson Resilience Scale and the multidimensional scale of perceived social support to assess the level of resilience and perceived social support among patients. Data were analyzed using descriptive and inferential statistics.

Results:

The findings revealed that the highest level of resilience was shown among the patients who are self-efficient with a mean score of 5.36 ± 1.392 while the respondents obtained the maximum social support from their family with a mean score of 19.37 ± 3.653. It was found that there was a strong positive correlation between resilience and perceived social support, which was statistically significantP< 0.05), whereas no association was found between the level of resilience and perceived social support scores with sociodemographic variables (P < 0.05).

Discussion:

Promoting resilience and good social support during illness should be an important component of cancer care.
Domestic Violence and its Associated Factors among Married Women of Varanasi
Authors: Srivastava Jyoti
Published: September 2023

Background:

Domestic violence experienced by married women with mental illness, with physical illness (obstetric and gynecological morbidity) and with no illness (normal healthy women), is a nearly universal phenomenon.

Materials and Methods:

The study design was cross-sectional case–control study. A total of 165 married women (group: mental illness, with physical illness and with no illness) between the ages of 16 and 45 were randomly selected. The study was conducted in the hospital, which is a tertiary care center with a huge catchment area that extends from Uttar Pradesh, to Bihar, and parts of Madhya Pradesh and Nepal. People living in this area largely come from middle, lower, and poor socioeconomic strata and have low level of literacy.

Results:

Perceived factors were reported exclusively by the married women with mental illness: alleged disrespect to elders, considers wife as property of husband, disability, instigated by family members, violating family norms, tradition of wife abuse in the family, unacceptable abnormal wife, unacceptable wife/daughter-in-law with mental illness, antisocial personality traits, and cannabis use dependence.

Conclusions:

Domestic violence (spousal) is most frequent and severe in married women with mental illness, then in married women with physical illness, and least in healthy married women. Higher husband's age and lower wife's age were predictors of domestic violence perpetrated by husbands in married healthy women.
Occupational Stress and Family Functioning among Working Women of Sonitpur District, Assam
Authors: Neog Munmi , Ahmed Nurnahar , Kollipara Sandeep
Published: September 2023

Background:

Modern life is full of stress. Occupational stress is a type of psychological stress that affects not only employees' health and well-being but also the productivity of organizations. Working women are typically responsible for their homes while also meeting professional obligations. When a woman returns home under the stress and expectations of her career, she may encounter obstacles and difficulties in carrying out her domestic responsibilities.

Aim:

This study aimed to assess occupational stress and family functioning among working women, working in selected workplaces in Sonitpur district.

Materials and Methods:

A descriptive research design was adopted for the study. A total of seventy working women were selected through convenient sampling technique. Sociodemographic data were collected by administering a self-structured sociodemographic pro forma. Occupational stress and family functioning were assessed using standardized tools such as Occupational Stress Index and McMaster Family Assessment Device, respectively.

Results:

About 64.3% (f = 45) of the working women had a moderate level of occupational stress. Communication, roles, affective response, affective involvement, and behavior control domains of family functioning showed to be unhealthy. However, problem-solving and general functioning domains of family functioning were found to be healthy among working women.

Conclusion:

The study findings revealed that the majority of the working women have moderate level of occupational stress and unhealthy functioning in certain domains of family functioning.
Depression, Anxiety, and Stress among Undergraduate MBBS and Nursing Students in Erode, Tamil Nadu
Authors: Periasamy Panneerselvam , Vajiravelu Suganthi , Chandrabose A. , Sasikala G. , Manivannan Janani , Umashankar Aishwarya
Published: September 2023

Background:

The main psychological stress among medical students was associated with anxiety and depression. Fear of unforeseeable situations, using equipment, speaking with patients, etc., is a typical issue among students. The two factors that are most directly associated with poor emotional states are physical and mental health.

Methodology:

Students from the Erode district of Tamil Nadu were recruited for this cross-sectional study. The study involved 273 undergraduate students who were randomly selected. Participants were selected by a systematic, random sampling technique. To measure the study's outcomes, the depression, anxiety, and stress scale-42 with 42 items was employed. Statistical significance was shown using aP= 0.05.

Results:

Among the 273 respondents, 80 (29.30%) were male and 193 (70.70%) were female. Among undergraduate students in Tamil Nadu's Erode district, there was a 40.29% prevalence of depression, a 40.39% prevalence of anxiety, and a 31.04% prevalence of stress. Female students had a 10.25 depression score than male students' 7.75 score. Furthermore, female (11.76) students had more stress scores than male students (9.30). Nursing and MBBS students had more anxiety.

Conclusions:

Stress, anxiety, and depression all have disturbingly high prevalence rates. Therefore, it is strongly advised to implement stress reduction strategies and to set up a student counseling center.
Rational points of algebraic varieties: a homotopical approach
Authors: Manin Yuri Ivanovich
Published: September 2023

This article, dedicated to the 100 th anniversary of I. R. Shafarevich, is
a survey of techniques of homotopical algebra, applied to the problem of
distribution of rational points on algebraic varieties.
We due to I. R. Shafarevich, jointly with J. Tate, one of the breakthrough
discoveries in this domain: construction of the so-called
Shafarevich-Tate groups and the
related obstructions to the existence of rational points. Later it evolved
into the theory of Brauer-Manin obstructions.
Here we focus on some facets of the later developments in Diophantine
geometry: the study of the distribution of rational points on them.
More precisely, we show how the definition of accumulating subvarieties, based
upon counting the number of points whose height is bounded by varying $H$,
can be encoded by a special class of categories
in such a way
that the arithmetical invariants of varieties are translated into homotopical
invariants of objects and morphisms of these categories.
The central role in this study is played by the structure of an assembler
(I. Zakharevich) in general, and a very particular case of it, an assembler on the family of unions of
half-open intervals $(a,b]$ with rational ends.
Recent therapeutic targets for the prevention and management of diabetic complications
Authors: Islam Md Shahidul , Cai Lu , Horowitz Michael
Published: September 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.
Hypothesis that alpha-amylase evokes regulatory mechanisms originating in the pancreas, gut and circulation, which govern glucose/insulin homeostasis
Authors: Pierzynowski Stefan G , Stier Christine , Pierzynowska Kateryna
Published: September 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.
Effect of sitagliptin combined with Yiqi yangyin huoxue decoction on clinical efficacy and hemorheology in early diabetic nephropathy
Authors: Ling Jun , Yang Yan-Hua
Published: September 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.
Effectiveness and safety of traditional Chinese medicine for diabetic retinopathy: A systematic review and network meta-analysis of randomized clinical trials
Authors: Li Hong-Dian , Li Ming-Xuan , Zhang Wen-Hua , Zhang Shu-Wen , Gong Yan-Bing
Published: September 2023

Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.
Pengaruh Keteladanan Guru Pendidikan Agama Kristen Dalam Pembentukan Karakter Anak Yang Berkebutuhan Khusus Di Sekolah Minggu Gereja Kristen Setia Indonesia Menining
Authors: Christia Verra Ria , Iswahyudi Iswahyudi , Setiawan Jimmy , Bintoro Wahyu
Published: September 2023

The teacher's example in character building is the beginning of making children with special needs qualified. The teacher's example is the basis for producing children with special needs to be of good character. It turns out that in creating the formation of children's character, it must be based on various aspects, one of which is seen from the teacher, so that children can imitate the attitudes and examples of their own teachers. The example of a teacher can be seen in daily activities with children with special needs, there will be clearly seen how the example of a teacher in educating children with special needs is. A teacher has the task of educating, instilling good character in children with special needs. This writing tries to find the influence of the teacher's example in shaping the character of children with special needs. The teacher's example is the basis for the formation of the child's character, and the teacher must also be a good example for children with special needs. Various tools and facilities that become supporters in creating a comfortable atmosphere are needed in the teaching process so that the child's learning process is not boring. The main purpose of the research is to find out how much influence the example of a teacher sees by children with special needs in character building.
 
Keteladanan guru dalam pembentukan karakter merupakan awal menjadikan anak berkebutuhan khusus berkualitas. Keteladanan guru menjadi dasar supaya menghasilkan anak-anak yang berkebutuhan khusus menjadi berkarakter yang baik. Ternyata, dalam menciptakan pembentukan karakter anak, harus didasari oleh berbagai aspek salah satunya adalah dilihat dari gurunya, sehingga anak dapat menirukan sikap dan keteladanan yang dimiliki oleh gurunya sendiri. Keteladanan seorang guru dapat dilihat dalam kegiatan sehari-hari bersama anak yang berkebutuhan khusus, di situ akan terlihat dengan jelas bagaimana keteladanan seorang guru dalam mendidik anak yang berkebutuhan khusus tersebut. Seorang guru memiliki tugas mendidik, menanamkan karakter yang baik kepada anak berkebutuhan khusus. Penulisan ini mencoba mencari pengaruh atas pengarug keteladanan guru dalam pembentukan karakter anak berkebutuhan khusus. Keteladanan yang dimiliki guru menjadi dasar pembentukan karakter anak, dan guru juga harus bisa menjadi contoh yang baik bagi anak yang berkebutuhan khusus. Berbagai alat dan sarana yang menjadi pendukung dalam menciptakan suasana yang nyaman sangat dibutuhkan dalam proses mengajar agar proses belajar anak tidak membosankan. Tujuan utama dari penelitian adalah untuk mengetahui seberapa besar pengaruh keteladanan seorang guru yang dilihat oleh anak berkebutuhan khusus dalam pembentukan karakter.
Objective assessment in the quality assurance system of the academic virtue of the university in the context of legal security
Authors: Helesh Anna , Mukan Nataliya , Davydchak Oleh , Huzii Ivanna , Dolinska Nataliia
Published: September 2023

The main objective of the article was to evaluate the quality assurance system of the university’s academic virtue in the context of regulatory security. In order to achieve the stated objective, dialectics and the historical method were used. In addition, the following methods were also used in the research process: the structural-logical method, the method of scientific abstraction, analysis and synthesis, modeling and the method of abstract conclusion. According to the results of the study it is concluded that the approached system has a complex internal structure, with significant impact on the educational process. definitely, it is proved that an objective evaluation in the system of quality assurance of academic virtue of the university, in the general framework of legal certainty, plays an important role in the institution of higher education and cannot be ignored. After all, it is precisely such components of academic virtue as: justice, trust, respect, responsibility, honesty that are at the same time universal values, moral and ethical ideals of a highly developed society and, fundamentally, the key to the successful development of the state as a whole in the democratic system.
Impacto de la invasión rusa a Ucrania en las finanzas mundiales
Authors: Kantsedal Nataliya , Chernenko Kseniia , Dugar Tetiana , Leha Olha , Yaloveha Liudmyla , Priydak Tatiana
Published: September 2023

The invasion of the Russian Federation into Ukraine, a sovereign country, has been interpreted from different points of view: However, beyond the different opinions, it is clear that this war, which took place in Eastern Europe, has meant a hard blow for global finances, with concrete effects in the increase of fuel prices (gas and coal), in high inflation rates and, according to data from the World Bank (WB, 2023), it has also created an international environment of restrictive financial conditions that hinder macroeconomic recovery in terms of sustainable economic development, after the COVID-19 pandemic. In this order of ideas, using a documentary methodology of geopolitical analysis, which values the geographic conditions of each country, its particular history and its international relations, the objective of the article was to interpret the impact of the Russian invasion of Ukraine on world finances. The results obtained allow us to conclude that the Russian invasion of Ukraine has had far-reaching consequences on world finance. The economic impacts of this invasion have been significant, with disruptions in supply chains, fluctuations in inflation and commodity prices, among others.