bluuebunny/crossref_metadata_2025 huggingface dataset:
Pentylenetetrazole-Induced Seizures in Wistar Male Albino Rats with Reference to Glutamate Metabolism
Authors: Kanchi Sivaprasad , Meesala Gurusekhar
Published: June 2024

Background and Purpose: Epilepsy is a common and heterogenous neurological disorder characterized by recurrent spontaneous seizures. Animal models like rats play a crucial role in finding of mechanism of epilepsy in different brain regions. i.e., cerebral cortex, cerebellum, hippocampus, and pons medulla. Glutamate is an important excitatory neurotransmitter in the central nervous system and also glutamate plays a vital role in neuronal development and memory. The process of neuronal death evolved by glutamate receptor activation, has been hypothesized in both acute and chronic degenerative disorders including epilepsy. Considering the multifactorial neurochemical and neurophysiological malfunctions consequent to epileptic seizures, a few antiepileptic drugs are designed, to mitigate the debilitating aspects of epilepsy.Methods: Rat model, pentylenetetrazole (PTZ), an anticonvulsant drug, was selected for the present study. Induction of epilepsy/convulsions was induced by an intraperitoneal injection of PTZ (60 mg/kg body weight) in saline. Biochemical assays performed through spectrophotometer.Results: Glutamine and Glutamine synthetase levels were decreased in the epileptic rats brain regions i.e., hippocampus, cerebellum, cerebral cortex, and pons medulla; glutamate dehydrogenase and glutaminase levels were increased in all the regions of epilepsy induced rats. Highest values are recorded in hippocampus when compared to other brain regions.Conclusion: PTZ suppresses the function of Glutamine and Glutamine synthetase activities in selected brain regions of rat and enhances the activities of the glutaminase and glutamate dehydrogenase when compared to control rats.
Cerebral Folate Transport Deficiency in 2 Cases with Intractable Myoclonic Epilepsy
Authors: Girgis Marian Y , Mahfouz Eman , Abdellatif Alshaimaa , Taha Farah , ElNaggar Walaa
Published: June 2024

Cerebral folate transport deficiency due to folate receptor 1 gene (FOLR1) gene mutation results from impaired folate transport across the blood: choroidplexus: cerebrospinal fluid (CSF) barrier. This leads to low CSF 5-methyltetrahydrofolate, the active folate metabolite. We are reporting two children with this treatable cerebral folate transport deficiency. Eight years and 9-month-old female presented with delayed milestones followed by regression, seizures, and intention tremors. On examination child had microcephaly, generalized hypotonia, hyperreflexia, unsteady gait, and incoordination. Magnetic resonance imaging (MRI) of brain revealed dilated ventricular system and cerebellar atrophy. Computed tomography (CT) of brain showed brain calcifications. Whole exome sequencing was finally performed, revealing homozygous nonsense pathogenic variant in FOLR1 gene in exon 3 c.C382T p.R128W, confirming the diagnosis of cerebral folate deficiency. Twelve-year-old female child presented with global developmental delay since birth, myoclonic jerks and cognitive regression. Child had generalized hypotonia and hyperreflexia. Her coordination was markedly affected with intention tremors andunbalanced gait. CT brain showed bilateral basal ganglia and periventricular calcifications with brain atrophic changes. MRI brain showed a prominent cerebellar folia with mild brain atrophic changes. Genetic testing showed a homozygous pathogenic variant was identified in FOLR1 C.327_328 delinsAC, p.Cys109Ter. Both patients were started on intramuscular folinic acid injections with a decrease in seizure frequency. However, their seizures did not stop completely due to late initiation of therapy. In conclusion, cerebral folate transport deficiency should be suspected in every child with global developmental delay, intractable myoclonic epilepsy, ataxia with neuroimaging suggesting cerebellar atrophy and brain calcifications. Response to folinic acid supplementation is partial if diagnosed late and treatment initiation is delayed.
Iron toxicity in lowland rice influenced by application of high potassic fertilizer with suitable cultivars enhanced productivity and climate resilience
Authors: Jevelin Swain , Rajendra Kumar Panda , Rabindra Kumar Nayak , Manoranjan Satapathy
Published: June 2024

Iron poisoning in low-land rice in India develops gradually and is primarily caused by anaerobic conditions in submerged rice fields. A high concentration of ferrous ions in the soil solution disrupts the potassium balance in rice plants, leading to adverse effects on crop growth. In the 2021–2022 period, an experiment was conducted in non-saline, iron-rich soil (pH–4.82, Fe–458.6 mg kg–1) to mitigate iron toxicity in rice cultivars through potassium nutrition. The experiment involved 4 potassium application doses (K-40, K-80, K-100 and K-120) and 32 rice cultivars, replicated twice using a split-plot design. Higher potassium doses led to increased tiller counts, but gradually decreased root length. Notably, cultivars like Kanchan, Indravati, Jagabandhu, Santepheap and Salibahan exhibited the lowest iron concentration in their grains compared to susceptible cultivars. Administering K-120 resulted in a yield increase of over 36.70 q ha-1. Grain yield increased with higher K dosage, although it did not affect total iron content. However, K doses did influence specific fractions of iron in the soil. Hence, potassium nutrition appears crucial in managing iron toxicity in inceptisols, especially when paired with cultivars tolerant to iron toxicity.
Elementy językowego obrazu świata w nauczaniu języka francuskiego w kontekście filologicznym
Authors: Dryjańska Agnieszka
Published: June 2024

In teaching French as a foreign language in the philological context, insufficient attention is paid to the development of lexical and semantic competences, especially in relation to culture. The linguistic worldview is an ethnolinguistic concept that integrates many different lexical phenomena such as polysemy, derivation, connotation and word structures in order to show the close relationship between lexis and culture. Showing a word in a complex network of lexical-semantic-compositional relations is a tool with strong didactic potential. The aim of this study is to identify this potential in the context of teaching French vocabulary. We focus on the theoretical background of lexical and semantic competences and on the analysis of the relationship between language, culture and meaning in ethnolinguistic and cognitive terms. The empirical part explores, in a quantitative and qualitative way, the methodology of teaching lexis as it is implemented in French language textbooks. The result of our study shows that this methodology, in terms of the presentation of vocabulary and the number and types of lexical exercises, is not sufficient for learning the real meaning of words. The linguistic worldview is a tool that may meet this challenge.
Uczniowie z doświadczeniem migracji na lekcjach języka niemieckiego w polskiej szkole podstawowej – perspektywa nauczycieli
Authors: Janicka Monika
Published: June 2024

In February 2022, the invasion of Ukrainian territories by Russian forces took place, leading to a mass exodus of the Ukrainian population from the war-affected areas. Many individuals who left Ukraine due to the war sought refuge in Poland, and their children began attending Polish schools. Some of these children appeared in Polish classes only temporarily, but as reported by the Ministry of Education and Science in September 2023, 180,000 students from Ukraine began their education in Polish schools. The influx of Ukrainian children into Polish schools posed various challenges, especially for foreign language teachers, as their classes became linguistically and culturally heterogeneous. The aim of the conducted study was to answer the following questions: (1) What kind of challenges do German language teachers face in classes where students from Ukraine are learning? (2) Which teaching techniques do German language teachers consider most effective in linguistically and culturally heterogeneous classes? The article presents the results of the study conducted through interviews using an unstructured dialogical method with four German language teachers teaching elementary school students with migration experience. The research framework was based on the concept of Universal Design for Learning, taking into account the principles of inclusive teaching.
Stability of granular media impacts morphological characteristics under different impact conditions
Authors: Wang Yifeng , Li Ran , Chi Zhipeng , Yang Hui
Published: June 2024

In planetary surfaces, oblique impact events are commonplace, and their study holds significant importance for understanding planetary impact processes and aiding in the design of landers and impactors. Current research predominantly focuses on simplified models to study the force and motion under vertical impact craters in terms of scale and impact loading. For oblique impacts, investigations have primarily concentrated on the final crater shape. However, the specific influence of impact load motion on particle bed movement and the precise impact angle’s effect on the ultimate crater shape during the impact process remain unclear. In this study, we used a custom-built oblique impact experimental setup to analyze changes in the velocity field of the particle bed and the horizontal movement of the impact load. Using quasi-static region to assess ellipticity, we aimed to reveal the state of particle movement during oblique impacts and explore the impact of impact angles and energies on crater formation. The results indicate that under large impact angles, the obliquely acquired kinetic energy is minimal, leading to a predominant static point source movement of the particle bed. At higher energy levels, the impact load primarily excavates downward, resulting in the formation of circular impact craters. These findings underscore the sensitivity of particle bed motion to impact angles, making it a crucial metric for assessing the impact of oblique angles on final crater morphology.
Energy-saving analysis of desalination equipment based on a machine-learning sequence modeling
Authors: Zhang Xiaodong , Jiang Yuepeng , Li Ke , Sun Yu
Published: June 2024

To control water quality and seawater desalination dosage, modeling the coagulation process of saltwater is crucial. With a focus on the features of seawater coagulation with a long lag, a machine-learning sequence-based modeling approach is suggested. The link between influent and effluent turbidities, flow rates, flocculant and coagulant dosages, and other parameters is modeled using structured units such as a gate recurrent unit encoder and a linear network decoder. The model’s validity is confirmed by numerical experiments based on real operating data, which also offer a solid foundation for managing flocculant and coagulant assistance reduction.
Automatic human identification using fingerprint images based on Gabor filter and SIFT features fusion
Authors: Jabar Sabat Ahily Hydr , Al Dujaili Mohammed Jawad , Abdulzahra Al Dulaimi Mohammed
Published: June 2024

Today, advancements in science and technology have spurred the rapid evolution of systems like electronic banking, demanding precise, swift, and secure identification of individuals based on their distinct traits. Among these traits, fingerprints stand out as a dependable means of identification, finding application in realms such as crime investigation and national border control due to their simplicity and heightened security. The qualities inherent in fingerprint-based identification have led to its widespread adoption over other identification methods. This article proposes a hybrid biometric system that integrates the Gabor filter and scale-invariant feature transform features and then uses support vector machine and K-nearest neighbors as classifiers, aiming to notably enhance authentication systems by mitigating issues seen in single-method biometric systems. Also, principal component analysis is used to reduce dimensions and eliminate redundancy. In this article, the famous database FVC2004 is used. Test results highlight the considerable reliability and accuracy of the proposed combined approach compared to systems reliant on a singular biometric method.
Study and mechanism of formation of phosphorus production waste in Kazakhstan
Authors: Smailov Bakyt , Ismailov Bakhytzhan , Zakirov Bakhtiyar , Turakulov Bakhriddin , Tursynbay Leskul , Aimenova Zhanar
Published: June 2024

This article contains information about the accumulated industrial waste from phosphorus production and methods for its recycling and disposal to produce marketable products. Monitoring of cottrel dust’s impact on the environment, namely, ground and surface water, soil, and atmosphere was carried out. The mechanism of formation of cottrel dust was studied. The dispersed, chemical, and phase compositions of the dust in furnace gases during the electrothermal smelting of phosphorites were determined. The sequence of chemical reactions during the formation of cottrel dust was elucidated. The ratios of initial components entering the chemical reaction and the thermodynamic parameters (Gibbs energy) were determined using the Chemistry HSC-6 software package. IR spectral and elemental analyses were carried out for determining cottrel dust’s functional groups and elemental composition. Based on modern instrumental studies, it was found that the total content of phosphorus(v) oxide in cottrel dust was 30.7%. This content of phosphorus(v) oxide is sufficient to use cottrel dust as an initial raw material for producing phosphorus-containing fertilizers. This method was proposed for processing cottrel dust to produce monocalcium phosphate on a production scale. The chemical composition of the resulting monocalcium phosphate was determined and confirmed by analytical methods. The proposed technology for producing monocalcium phosphate from cottrel dust is recommended for use in the agro-industrial complex.
Roles and Abilities of Academic and Research Librarians in Optimizing Access to Information: An Interpretative Analysis from the Romanian Librarians’ and Users’ Perspective
Authors: Popescu Elena , Madge Octavia-Luciana
Published: June 2024

This study addresses the role of Romanian academic and research librarians in optimizing access to information in the digital age, in relation to quality management and knowledge management. The novelty of this study consists in its parallel analysis of both librarians’ and users’ perspectives on librarians’ roles and abilities in optimizing access to information. The results obtained by means of interpretative qualitative analysis combined with descriptive quantitative analysis revealed that Romanian librarians succeed in providing good information services, however, the demands and expectations of users highlight a continuous need for integration of librarians into the mission of the universities and research institutes, and knowledge sharing and a series of innovations are recommended. The results obtained by interpretative analysis, combined with quantitative analysis for corroboration, point to four interrelated themes regarding the Romanian librarians’ roles and abilities in optimizing access to information. The first principal idea is that librarians’ abilities and competencies are key assets for Romanian academic and special research libraries. The second is that Romanian librarians need training in knowledge management and quality management. The third is that embedded librarianship and knowledge sharing could add quality to libraries services. Finally, the fourth is that competency management can determine engagement of Romanian librarians in improving access to information.
All-optical modulator with photonic topological insulator made of metallic quantum wells
Authors: Wang Haiteng , Niu Junru , Chen Qiaolu , Zhao Sihan , Shao Hua , Yang Yihao , Chen Hongsheng , Li Shilong , Qian Haoliang
Published: June 2024

All-optical modulators hold significant prospects for future information processing technologies for they are able to process optical signals without the electro-optical convertor which limits the achievable modulation bandwidth. However, owing to the hardly-controlled optical backscattering in the commonly-used device geometries and the weak optical nonlinearities of the conventional material systems, constructing an all-optical modulator with a large bandwidth and a deep modulation depth in an integration manner is still challenging. Here, we propose an approach to achieving an on-chip ultrafast all-optical modulator with ultra-high modulation efficiency and a small footprint by using photonic topological insulators (PTIs) made of metallic quantum wells (MQWs). Since PTIs have attracted significant attention because of their unidirectional propagating edge states, which mitigate optical backscattering caused by structural imperfections or defects. Meanwhile, MQWs have shown a large Kerr nonlinearity, facilitating the development of minimally sized nonlinear optical devices including all-optical modulators. The proposed photonic topological modulator shows a remarkable modulation depth of 15 dB with a substantial modulation bandwidth above THz in a tiny footprint of only 4 × 10 µm2, which manifests itself as one of the most compact optical modulators compared with the reported ones possessing a bandwidth above 100 GHz. Such a high-performance optical modulator could enable new functionalities in future optical communication and information processing systems.
Motor Control of Distinct Layer 6 Corticothalamic Feedback Circuits
Authors: Martinetti Luis E. , Autio Dawn M. , Crandall Shane R.
Published: June 2024

Layer 6 corticothalamic (L6 CT) neurons provide massive input to the thalamus, and these feedback connections enable the cortex to influence its own sensory input by modulating thalamic excitability. However, the functional role(s) feedback serves during sensory processing is unclear. One hypothesis is that CT feedback is under the control of extrasensory signals originating from higher-order cortical areas, yet we know nothing about the mechanisms of such control. It is also unclear whether such regulation is specific to CT neurons with distinct thalamic connectivity. Using mice (either sex) combined with in vitro electrophysiology techniques, optogenetics, and retrograde labeling, we describe studies of vibrissal primary motor cortex (vM1) influences on different CT neurons in the vibrissal primary somatosensory cortex (vS1) with distinct intrathalamic axonal projections. We found that vM1 inputs are highly selective, evoking stronger postsynaptic responses in CT neurons projecting to the dual ventral posterior medial nucleus (VPm) and posterior medial nucleus (POm) located in lower L6a than VPm-only–projecting CT cells in upper L6a. A targeted analysis of the specific cells and synapses involved revealed that the greater responsiveness of Dual CT neurons was due to their distinctive intrinsic membrane properties and synaptic mechanisms. These data demonstrate that vS1 has at least two discrete L6 CT subcircuits distinguished by their thalamic projection patterns, intrinsic physiology, and functional connectivity with vM1. Our results also provide insights into how a distinct CT subcircuit may serve specialized roles specific to contextual modulation of tactile-related sensory signals in the somatosensory thalamus during active vibrissa movements.
Validação do histórico de enfermagem para Instituição de Longa Permanência para Idosos
Authors: Antunes Juliane de Fátima Santos , Duran Erika Christiane Marocco , Costa Paula Cristina Pereira da , Okuno Meiry Fernanda Pinto
Published: June 2024

Objetivo: construir e validar o conteúdo de um histórico de enfermagem para Instituição de Longa Permanência para Idosos. Métodos: estudo metodológico dividido nas etapas: identificação dos principais Diagnósticos de Enfermagem na literatura, elaboração do instrumento, validação com especialistas pela técnica Delphi e reestruturação do instrumento baseado na Teoria do Déficit de Autocuidado. Resultados: os 41 artigos selecionados resultaram em 78 principais Diagnósticos de Enfermagem, que fundamentaram a elaboração de um instrumento com 104 itens. Foram selecionados e convidados 37 especialistas para validação, e 10 aceitaram contribuir. Após a validação, o histórico foi finalizado com 90 itens, com Índice de Validação de Conteúdo entre 0,80 e 1,0 na primeira rodada. As sugestões validadas na segunda rodada obtiveram concordância de 80 a 100%, de modo que a validação do conteúdo do instrumento foi concluída. Conclusão: foi construído e validado o conteúdo de histórico de enfermagem para Instituição de Longa Permanência para Idosos baseado na Teoria do Déficit de Autocuidado. Contribuições para a prática: trata-se de importante recurso que poderá ser utilizado na prática clínica.
Perfil das violências contra as pessoas lésbicas, gays, bissexuais, travestis e transsexuais
Authors: Melo Meggie Adriele de Albuquerque , Pontes Gabriela de Sousa , Celino Suely Deysny de Matos , Coelho Ardigleusa Alves , Silva Valdecir Carneiro da , Costa Gabriela Maria Cavalcanti
Published: June 2024

Objetivo: descrever o perfil das notificações das violências contra as pessoas lésbicas, gays, bissexuais, travestis e transexuais. Métodos: estudo transversal, descritivo, com dados do Sistema de Informação de Agravos de Notificação, sobre os casos de violência contra as pessoas LGBT, ≥ 10 anos de idade. Para a identificação desta população foram utilizadas no estudo as variáveis da ficha de notificação: orientação sexual, identidade de gênero e violência motivada. Resultados: do total de 302 notificações contra a população LGBT, 209 (62,2%) foram vítimas de violência interpessoal, predominantes na faixa etária de 20 a 59 (81,3%), sendo 58,9% gays/lésbicas e 16,3% mulheres transexuais. Quanto à motivação está associada à homofobia/lesbofobia/bifobia/transfobia (54,3%), com maior ocorrência em suas residências e praticadas por homens. Conclusão: o perfil aponta que a população foi vítima de violência relacionada à homofobia, lesbofobia, bifobia, transfobia com a maior ocorrência em suas residências e praticadas por homens. Contribuições para a prática: reforçar a relevância epidemiológica da notificação compulsória da violência com destaque para o preenchimento das opções de orientação sexual e identidade de gênero, para favorecer o rastreio das informações e o planejamento de ações para reduzir as vulnerabilidades que os abarcam.
Diferencias de género en el rendimiento físico y la evaluación psicológica en el equipo nacional de atletismo cubano
Authors: Feria-Madueño Adrián , Montoya César , López Larién , Gónzalez-Carballido Luis Gustavo
Published: June 2024

Introduction: Elite sports pose potential health risks, but are vital to the well-being of society. In Cuban society, sport is an integral part of personal development and public health, fostering unity and promoting female participation for sustainable growth. Athletics is one of the most important sports in Cuban sport, and should be approached both from the point of view of sports training and sports psychology. Purpose: The aim of this study was to provide a description of conditional variables in a countermovement jump (CMJ), mood profile, self-efficacy, and the leg-hip height index among athletes from the Cuban national athletics pre-selection team, differentiated by gender. Methods: Our sample consisted of the Cuban national athletics pre-selection team. Results: Mood profile analysis using the Profile of Mood States (POMS) did not reveal significant gender differences, with a small effect size for gender. Men showed a slightly greater trend towards vigor compared to women. Significant differences in self-efficacy were observed between men and women in their confidence levels to achieve jump heights between 21 and 40 cm using the CMJ. However, no significant differences were found for jumps exceeding 40 cm, highlighting the importance of strategies to enhance athletes’ psychological needs and self-efficacy. Conclusions: This study suggests that the association between tension-related anxiety and performance indicators related to jump height may play a crucial role in determining specific profiles in male and female Cuban athletes. Our comprehensive analysis contributes to understanding gender differences in performance factors. These findings provide valuable insights for future research and athlete development strategies.
The academic use of social media in distance education and its relation to the reduction of the feeling of isolation
Authors: Manousou Evangelia , Koutsogiannopoulou Nikolitsa
Published: June 2024

Academic use of social media has become an important component of the educational process of distance learning. The present study investigates the educational use of social media in distance education and the factors leading to it, in order to determine the impact of this use on reducing the feeling of isolation experienced by the students of the Hellenic Open University (HOU). The behavioral intention for use and the actual use of social media in the context of distance education are investigated, taking into account the factors of the Technology Acceptance Model (TAM). The sample consisted of 147 undergraduate and postgraduate students of HOU. The data collection tool was an improvised questionnaire structured in 4 axes, with 18 closed-ended questions. The results obtained show that the majority of students strongly supports and utilizes social media for educational purposes. The results also indicate that the more students consider social media useful in the context of their studies, the more they intend to use them and ultimately the more intensively they do use them. The finding that the educational use of social media is positively related to the stimulation of the HOU students’ feeling of isolation is important. It highlights the fact that social media are useful and supportive tools in the context of distance education. The findings of this study are in agreement with previous relevant studies and provide helpful guidance for future research.
Parameters and Effects of Magnetic Field and Potassium Carbonate in Water. Applications
Authors: Ignatov I. , Stankov I.K.
Published: June 2024

The polar water molecule has an angle between the two-hydroxyl O–H bonds of 104.5∘. The unequal sharing of electrons gives a slight negative charge near the oxygen atom and a slight positive charge near the hydrogen atoms of the water molecule. Water is a polar solvent. Hydrogen electromagnetic bonds are formed between water molecules. They involve hydrogen atoms from one water molecule and oxygen from another one. A permanent magnetic field influences the formation of hydrogen bonds between water molecules. Current research by Wu and Brant, 2020 illustrates that the water conductivity at the magnetic induction B = 13500 or 1.35 T increases from 100 to 250 μS · cm−1. The amount of protons in water (H+) decreases with the water alkalization and increasing pH. The work by Yap and co-authors’ indicates that stronger effects on pH, oxidation-reduction potential (ORP), and dissolved oxygen (DO) are observed in the non-reversed polarity of the magnets. Our study uses a constant magnet with the magnetic induction B = 3000 G or 0.3 T; eight permanent magnets are applied to 1000 L of water. Potassium carbonate (K2CO3) is also added, by increasing the alkalinity of water. The application is in livestock as drinking water for sheep and goats.
Про хід, результати та проблеми оцінювання наукових установ Національної академії наук України у 2023 році
Authors: Єгоров Ігор Юрійович , Жукович Інна Анатоліївна , Красноносова Олена Миколаївна , Артюшенко Віктор Вікторович
Published: June 2024

У статті висвітлено результати оцінювання ефективності діяльності наукових установ НАН України та їхніх підрозділів, яке відбувалося у 2023 р. за оновленою Методикою оцінювання НАН України, а також результати апробації бальної системи оцінювання, що проводилася одночасно. Розкрито деякі організаційні аспекти процесу оцінювання. Розглянуто результати опитування експертів та членів постійних комісій за науковими напрямами секцій НАН України щодо запровадження бальної системи оцінювання на постійній основі. Проаналізовано особливості оцінювання у 2023 р. і проблеми, що виникали під час його проведення.
Association Between the COI and Excess Health Care Utilization and Costs for ACSC
Authors: Maholtz Danielle , Page-Goertz Christopher K. , Forbes Michael L. , Nofziger Ryan A. , Bigham Michael , McKee Bryan , Ramgopal Sriram , Pelletier Jonathan H.
Published: June 2024

BACKGROUND AND OBJECTIVES

The authors of previous work have associated the Childhood Opportunity Index (COI) with increased hospitalizations for ambulatory care sensitive conditions (ACSC). The burden of this inequity on the health care system is unknown. We sought to understand health care resource expenditure in terms of excess hospitalizations, hospital days, and cost.

METHODS

We performed a retrospective cross-sectional study of the Pediatric Health Information Systems database, including inpatient hospitalizations between January 1, 2016 and December 31, 2022 for children <18 years of age. We compared ACSC hospitalizations, mortality, and cost across COI strata.

RESULTS

We identified 2 870 121 hospitalizations among 1 969 934 children, of which 44.5% (1 277 568/2 870 121) were for ACSCs. A total of 49.1% (331 083/674 548) of hospitalizations in the very low stratum were potentially preventable, compared with 39.7% (222 037/559 003) in the very high stratum (P < .001). After adjustment, lower COI was associated with higher odds of potentially preventable hospitalization (odds ratio 1.18, 95% confidence interval [CI] 1.17–1.19). Compared with the very high COI stratum, there were a total of 137 550 (95% CI 134 582–140 517) excess hospitalizations across all other strata, resulting in an excess cost of $1.3 billion (95% CI $1.28–1.35 billion). Compared with the very high COI stratum, there were 813 (95% CI 758–871) excess deaths, with >95% from the very low and low COI strata.

CONCLUSIONS

Children with lower neighborhood opportunity have increased risk of ACSC hospitalizations. The COI may identify communities in which targeted intervention could reduce health care utilization and costs.
Biogenic production and their sedimentary record: a review
Authors: Cruz-Guevara Luis Enrique , Cruz-Ceballos Luis Felipe , Avendaño-Sanchez Gladys Marcela
Published: June 2024

The recognized biogenic production corresponds to corporal materials, and ethological structures (ichnofossils). Ethological structures include bioturbation, bioerosion, and biogenic granule-classification structures. Biogenic materials and structures traditionally include biogenic aggregates (such as fecal pellets or castings and coprolite grapstones); bioturbation structures or ichno-structures (burrows, tracks, trails, and root penetration structures); biogenic granulo-classification or biostratification structures (algal and bacterial stromatolites of graded bedding of biogenic origin); bioerosion structures (borings, scrapings, and bitings); and biolitites (e.g., reef structures). This paper presents a new classification system for biogenic materials applicable to the fossil record. It summarizes our efforts to standardize terminology, use new and existing terms, correct any contradictions in some terms, and facilitate teaching and learning processes related to this subject. In our proposal, biogenic production is used for any materials or structures produced, built, modified, or used by living organisms. Biogenic production includes the following five groups: direct production (corporal, biodeposition, bioexhudation, and bioclaustration materials and structures); bio-modified materials and structures (predation, bioerosion, and bioturbation); bio-built materials and structures (biofoodcaches, bioconstructions, and biostratification structures); microbial induced materials and structures; and biotools. All types of biogenic production have examples in the sedimentary record.
“The work is only in a moment”: Max Dvořák and the Meaning of the Work of Art
Authors: Murár Tomáş
Published: June 2024

This study examines Max Dvořák‘s previously unknown papers prepared for his one-semester lecture series at the university of Vienna in 1913. Dvořák titled these lectures “explanations of Selected Works of Art“ (Erklärung ausgewählter Kunstwerke) and in doing so developed a distinctive method within the art historical research of the so-called vienna School of Art History. The paper interprets the lectures through a close reading of the method as a parallel to the change in the concept of the work of art as it occurred in the philosophy and practice of art at the beginning of the twentieth century, demonstrated in the study by examples from the thinking of the German philosopher Oskar Becker and a transformation of the meaning of painting by the French artist Marcel Duchamp. As the study shows, such analogies allow us to understand the meaning of the work of art in Max Dvořák‘s art history in a new way.
Metamorphoses
Authors: Tóth Áron
Published: June 2024

The Esterházy Palace in Fertőd is part of Hungary’s largest eighteenth-century residential complex. After severe damage at the end of the Second World War and in the 1950s, the palace was repeatedly renovated for almost seventy years. Between 2021 and 2022, the state apartments in the main building and some adjoining rooms underwent extensive conservation and restoration. Due to the palace’s complicated history and the inconsistent interventions of the post-war period, it was difficult to preserve as many remnants as possible. The aim was to preserve and display all historical periods from the beginning to the present, as they provide information about all the historical and cultural changes over the centuries. From this point of view, the contradictory relationship between some previous interventions and the principles laid down in documents such as the Venice Charter, the Nara Document or the UNESCO Convention of the Intangible Heritage were considered a legacy that can no longer be erased from the history of the palace. Based on conservation and restoration principles crystallised in the second half of the twentieth century and considering the changes in the field of heritage conservation since the 1990s, an attempt was made to preserve the tangible and intangible heritage as far as possible. With this in mind, the rooms were divided into three groups, each of which is subject to a different conservation and restoration method.
IN VITRO AND IN SILICO INHIBITORY ACTIVITY OF ANGIOTENSIN-CONVERTING ENZYME II AND ANTI-INFLAMMATORY EFFECTS OF NATURAL COMPOUNDS FROM RHEUM OFFICINALE ROOTS
Authors: Cuong Nguyen Manh , Khanh Pham Ngoc , Huong Tran Thu , Ha Nguyen Xuan , Anh Hoang Thi Ngoc , Loc Vu Thanh , Nghi Do Huu , Thao Do Thi , Ha Trinh Thi Thu , Hung Nguyen Phi , Ha Vu Thi , Wessjohann Ludger A.
Published: June 2024

Rhubarb roots (Rheum officinale), a common medicinal plant in folk remedies, and their chemical compositions were investigated for their inhibitory activity of angiotensin-converting enzyme II and anti-inflammatory effects by inhibiting NO production and IL-6 expression. Four natural compounds, including two anthraquinones, chrysophanol (2) and emodin (3), and two stilbenes, rhapontigenin (1) and trans-piceatannol (4), were isolated from the roots of Rhubarb. The results showed that rhapontigenin (1) exhibited an inhibitory effect on the ACE-2 enzyme with an IC50 value of 132 mM. In an in silico study, rhapotigenin (1) had a binding energy value of -9.32 kcal/mol, lower than MLN-4760, on ACE-2. Both rhapontigenin (1) and emodin (3) exhibited inhibitory activity on NO production in primary cultures of macrophages RAW264.7, with IC50 values ranging from 5.65 to 32.3 µg/mL. This is the first study of the anti-ACE-2 and anti-inflammatory activity of Rhubarb root extract and its constituents.
Influence of Mathematical Modeling in GeoGebra Environment on Learning Derivative
Authors: Sekulic Tanja , Takaci Djurdjica , Strboja Mirjana , Kostic Valentina
Published: June 2024

This study examined the influence of mathematical modeling in GeoGebra environment on students' learning of the concept of the derivative and its application. The study included an experimental and a control group with 204 first-year undergraduate students of applied sciences. The
students in the experimental group (102 students) conducted the modeling process in the GeoGebra environment, while the students in the control group (102 students) modeled the same problems without the use of computer technologies. A pretest-posttestdelayed test approach was applied. While
the two groups had the same pretest results, the experimental group had significantly better results than the control group on both the posttest and the delayed test.
Preservice Mathematics Teachers’ Instrumental Genesis and Their Development of Geometric Knowledge in a Dynamic Geometry Environment
Authors: Yao Xiangquan
Published: June 2024

The emergence of dynamic geometry software influences the teaching and learning of geometry among learners of all ages. Relying on the theory of instrument, this study examined the relationship between preservice mathematics teachers’ instrumental genesis and their development
of geometric knowledge when solving geometry construction problems with the Geometer’s Sketchpad (GSP). Data analysis revealed the coevolution between instrumental genesis and geometric knowledge. Two preservice secondary mathematics teachers’ explorations on two geometry problems
are shared to illustrate this coevolutionary relationship. This relationship can be summarized as the following. Guided by his prior knowledge of geometry and GSP techniques, the participant first used particular GSP tools to obtain a geometric figure possibly through a non-constructible method.
Through manipulating this geometric figure by various modalities of dragging and measuring as well as other instrument-mediated actions, the participant observed new geometric properties. The participant then used this newly developed knowledge to guide his GSP usage, which led him to create
a dynamic figure or develop an alternative construction. This process might go through multiple iterations. It highlights the dynamic interactions among the learner, mathematical task, and technological tool, through which new geometric knowledge and meaningful ways of using technology emerge.
Handgrip strength test for the diagnosis of long QT syndrome
Authors: Komoliatova V. N. , Makarov L. M. , Akopyan A. G. , Komarov A. N. , Aksenova N. V. , Besportochny D. A.
Published: June 2024

Long QT syndrome (LQTS) assessment is based on the QT/ÖRR equation (the so-called Bazett's formula) and calculating the corrected QT (QTc). However, this formula reliably estimates the QT interval in the heart rate range (HR) of 60-90 bpm, which makes it difficult to diagnose LQTS in patients with sinus bradycardia, typical of this disease.

Aim. To improve the LQTS diagnosis in patients with sinus bradycardia using the handgrip strength test.

Material and methods. A total of 188 patients aged 5-53 years (16 [13;17]) were examined: group I — 40 healthy children aged 9-17 years (14 [12;16]); group II — 98 athletes with sinus bradycardia <60 bpm aged 16 [16;17] years; group III — 50 patients with LQTS aged 5-53 years (12 [10;16]). The handgrip strength test consisted of regular rhythmic compression of a hand expander with a resistance of 20 kg until the heart rate increased >60 bpm. The patients had an electrocardiogram recorded twice before and after the handgrip test. Heart rate, QT and QTc intervals were analyzed.

Results. In all groups, after using the expander, there was a significant increase in heart rate, QT interval shortening and QTc interval prolongation. QTc interval prolongation after the handgrip test >460 ms was a highly sensitive marker of LQTS (Se 96%, Sp 60%).

Conclusion. Proposed handgrip test for sinus bradycardia makes it possible to increase heart rate, which ensures a more correct use of the Bazett's formula for assessing the corrected QT interval (QTc). QTc interval prolongation over 460 ms after the handgrip test is a highly sensitive additional marker for identifying patients with LQTS.
Treatment of renal artery fibromuscular dysplasia with drug-eluting balloon angioplasty and intravascular imaging: a case report
Authors: Shukurov F. B. , Taliuridze M. T. , Kharlap M. S. , Kardashova M. A. , Fedotova N. P. , Vasiliev D. K. , Feshchenko D. A. , Shanoyan A. S.
Published: June 2024

Fibromuscular dysplasia (FD) is a segmental, non-inflammatory and non-atherosclerotic disease of vascular smooth muscle of unknown etiology, which leads to stenosis of smalland medium-sized arteries. The choice of surgical treatment tactics for renal artery FD depends on the severity of clinical manifestations and the response to the conservative drug treatment used. Young age, female sex, high blood pressure with failure to achieve target values with therapy, as well as the absence of atherosclerotic involvement of other arterial systems gives reason to suspect renal artery FD. According to modern guidelines, the invasive treatment of hemodynamically significant renal artery stenoses includes transluminal drug-eluting balloon angioplasty. In this disease, renal artery stenting is not recommended. However, stent implantation is required if balloon angioplasty did not give the optimal result or in case of periprocedural complications, such as arterial dissection. Open reconstructive surgery is indicated for complex anatomy of the related artery, macroaneurysms in which stent grafts are ineffective, refractory intimal fibroplastic lesions, increased risk of endovascular treatment, or after unsuccessful endovascular intervention. The article presents a case of a young patient with renal artery FD, renovascular arterial hypertension, who successfully underwent renal artery transluminal drugeluting balloon angioplasty.
Right heart thrombosis in patients with pulmonary embolism: a case series
Authors: Teterina M. A. , Ubaydullaeva D. A. , Farzalieva N. A. , Nazyrova A. R. , Jayasinghe Havpage M. G. , Lapshin A. A. , Meray I. , Kobalava Zh. D.
Published: June 2024

Currently, recommendations have been developed for the treatment of patients with pulmonary embolism. However, the optimal management tactics for such patients in the presence of right heart thrombosis remains a matter of argument. Timely detection of right heart thrombosis can influence the choice of treatment tactics, which will help reduce the risk of adverse outcomes. The article presents three clinical cases with different clinical course options and management strategies that take into account risk factors and prognosis.
2023 Updated European Society of Cardiology guidelines on heart failure
Authors: Rakisheva A. G. , Kuanyshbekova R. T.
Published: June 2024

This article presents the new data of the 2023 European Society of Cardiology guidelines for the management of patients with acute and chronic heart failure, discussing key aspects, including their basic principles, recommendations for pharmacological and non-pharmacological treatment. In addition, their potential impact on the management of patients with heart failure was described.
Results of the XI Forum of Young Cardiologists of the Russian Society of Cardiology with international participation "Modern trends in the development of cardiology: new clinical solutions"
Authors: Lyapina I. N. , Kruchinova S. V.
Published: June 2024

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Resemantización de códigos en el cine negro español: la producción de Alberto Rodríguez como estudio de caso.
Authors: Garcia Angeles Martinez , Gómez-Aguilar Antonio
Published: June 2024

Este artículo tiene como objetivo principal analizar los códigos visuales y el universo diegético manifiestos en el cine negro del director de cine Alberto Rodríguez para averiguar si en sus procedimientos existe una voluntad de resemantización del género. Para ello se ha creado una herramienta metodológica que combina la teoría de la imagen, la narrativa fílmica y la teoría del guion y que se centra fundamentalmente en el análisis de personajes y espacios. La muestra elegida se circunscribe a las últimas cuatro películas del director: Grupo 7 (2012), La isla mínima (2014), El hombre de las mil caras (2016) y Modelo 77 (2022). Tras el análisis y la discusión de los datos, se concluye que el cine de Alberto Rodríguez supone una vuelta a los estándares del género del cine negro clásico, pero actualizando códigos y adaptándolos a los intereses del director, que se centra en plantear preguntas al espectador sobre la realidad de su país en lo referente a cuestiones de dudosa moralidad. De esta forma, la obra de Alberto Rodríguez se revela como paradigma del Spanish Neonoir, que vuelve a patrones básicos para, desde ahí, conectar con el espectador y remover su conciencia.
NUMERICAL SIMULATION OF PSEUDOPLASTIC FLUID FLOW OVER A SQUARE CYLINDER USING ANSYS FLUENT
Authors: Sarkar Sudipto , Rawat Bhawna
Published: June 2024

Flow of any non-Newtonian fluid past a bluff body requires considerable attention due to its involvement in chemical, polymer, and process engineering. In the current study, numerical simulation of the flow past a square cylinder was conducted at Reynolds number Re = 100 in a pseudoplastic fluid flow environment (0.1 ≤ n < 1.0, where n represents the power index of non-Newtonian fluid) using ANSYS Fluent. Instantaneous and time-averaged flow fields along with the flow parameters were calculated to understand the behavior of pseudoplastic flow in the presence of an obstacle (i.e., the square cylinder). It was observed that the drag force value increased in the pseudoplastic fluid flow compared to that in Newtonian fluidflow (n = 1), whereas the vortex shedding frequency decreased as the n value decreased. Close to n = 0.4, clear evidence of flow instability was seen, which drastically changed the vortex shedding mechanism and affected the flow downstream from the cylinder. In addition, at n = 0.1 the fluid flow stood still downstream due to very high flow resistance-a common feature of flow fields with a very high pseudoplastic nature.
NUMERICAL INVESTIGATION OF SUBMERGED HYBRID CAVITATION JET NOZZLE BASED ON STRESS-BLENDED EDDY SIMULATION MODEL
Authors: Xie Honggang , Du Mingjun
Published: June 2024

Cavitation jet technology is extensively applied in fields such as mechanical processing, rock fragmentation,
and energy development. To further enhance the cavitation capability of the nozzle, first a
submerged organ pipe-angular hybrid cavitation nozzle model is established using the software SOILDWORKS.
Second, the stress blended eddy simulation (SBES) technology is applied, and the jet
law of internal and external flow field of submerged cavitation nozzle is studied numerically using
FLUENT. Finally, the periodic shedding of cavitation clouds and the velocity characteristics and vapor
volume fraction are studied for different expansion or contraction angles. The study revealed that the
cavitation first occurs in the expansion section. With the development of cavitation, the asymmetry of
the cavitation cloud increases significantly. Under an inlet pressure of 20 MPa, the fluctuation part of
velocity is more concentrated. As the pressure increases, the maximum jet distance and velocity also
increase.