bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of direct oral anticoagulants for preventing venous thromboembolism in hospitalized cancer patients: a national multicenter retrospective cohort study
Authors: Wu Shuyi , Wang Haiping , Li Chunbao , Tao Jingjing , Zhu Xiaoli , Dai Hengfen , Duan Hongfan , Hu Tian , Li Miao , Qu Fenfen , Wei Yun , Wang Chunhua , Zhang Jinhua
Published: July 2024

Introduction

Studies on the use of direct oral anticoagulants (DOACs) for preventing venous thromboembolism (VTE) in hospitalized cancer patients are lacking. Therefore, we conducted a multicenter retrospective cohort study to evaluate the efficacy and safety of DOACs versus low-molecular-weight heparin (LMWH) for the primary prevention of VTE in hospitalized cancer patients.

Methods

Clinical outcomes included thrombosis, VTE, other thrombosis, all bleeding, major bleeding, nonmajor bleeding, and all-cause death. A 1:1 cohort of rivaroxaban and LMWH patients was created by propensity score matching.

Results

A total of 2,385 cancer patients were included in this study. During the 3-month follow-up period, 129 (5.4%) thrombosis events occurred, 63 (2.7%) of which were VTEs and 66 (2.8%) of which were other thrombosis events. All bleeding occurred in 163 (6.8%) patients, 68 (2.9%) had major bleeding, and 95 (4.0%) had nonmajor bleeding. All-cause deaths occurred in 113 (4.7%) patients. After adjusting for various confounders, the incidence of thrombosis and other thromboses was significantly lower in the rivaroxaban group than in the LMWH group [OR 0.543, 95% CI (0.343–0.859), p = 0.009; OR 0.461, 95% CI (0.241–0.883), p = 0.020]. There were no significant differences in incidence of VTE, total bleeding, major bleeding, nonmajor bleeding, or all-cause death.

Conclusion

In oncology patients receiving thromboprophylaxis, rivaroxaban has a lower incidence of thrombosis and other thrombosis and a similar incidence of VTE as LMWH and does not increase the risk of bleeding. Rivaroxaban may be an attractive alternative to LMWH for preventing VTE in hospitalized cancer patients.
Mitochondrial dysfunction and its association with age-related disorders
Authors: Somasundaram Indumathi , Jain Samatha M. , Blot-Chabaud Marcel , Pathak Surajit , Banerjee Antara , Rawat Sonali , Sharma Neeta Raj , Duttaroy Asim K.
Published: July 2024

Graphical Abstract

The figure shows the effect of mitochondrial dysfunction and mitophagy on stem cells leading to aging.
Chronotype as a predictor of athletic performance in youth with mild intellectual disabilities
Authors: Kurtoğlu Ahmet , Eken Özgür , Türkmen Musa , Çar Bekir , Setiawan Edi , Yermakhanov Baglan , Alotaibi Madawi H. , Elkholi Safaa M.
Published: July 2024

Aim

This study aimed to explore the influence of circadian rhythms on athletic performance in individuals with mild intellectual disabilities (ID), with a specific focus on elucidating the association between chronotype and various performance metrics.

Methods

The study was a cross-sectional study consisting of 30 male participants aged between 11 and 19 years and diagnosed with mild ID. The chronotypes of all participants were assessed using the Childhood Chronotype Questionnaire (CCQ). Performance assessments were divided into three groups. Group A tests [sit and reach, medicine ball throw (MBT), plank], group B tests [handgrip strength (HGS), standing long jump (SLJ), 20-m sprint (20 ms)] and group C tests [vertical jump (VJ), hanging with bent arm (HBA), Illinois agility test) in order to ensure adequate rest periods between tests and not to affect the results. These group tests were performed 48 h apart, between 09:00–10:00 and 17:00–18:00, after a dynamic warm-up session.

Results

Significant variations were observed in the sit-and-reach test (t = −4.154, d = −0.75, p < .001), HGS (t = −2.484, d = −0.45, p = .019), SLJ (t = −2.117, d = −0.38, p = .043), VJ (t = −5.004, d = −0.91, p < .001), and plank duration (t = −4.653, d = −0.84, p < .001). Evening performances showed improvement in MBT, HBA, 20 ms, and the Illinois agility test, although these differences were not statistically significant (p > .05). Notably, positive correlations were identified between participants’ chronotypes and their performance in HBA (morning/evening; r = .693, p = .026; r = .656, p = .039, respectively) and the plank (evening; r = .717, p = .020), with negative correlations noted in the 20 ms (morning/evening; r = −.703, p = .023; r = −.710, p = .021, respectively).

Conclusion

The findings suggest that individuals with mild ID exhibit enhanced athletic performance during evening hours. These insights underscore the importance of considering chronotype in tailoring exercise interventions for this population to optimize outcomes.
CSXAI: a lightweight 2D CNN-SVM model for detection and classification of various crop diseases with explainable AI visualization
Authors: Prince Reazul Hasan , Mamun Abdul Al , Peyal Hasibul Islam , Miraz Shafiun , Nahiduzzaman Md. , Khandakar Amith , Ayari Mohamed Arselene
Published: July 2024

Plant diseases significantly impact crop productivity and quality, posing a serious threat to global agriculture. The process of identifying and categorizing these diseases is often time-consuming and prone to errors. This research addresses this issue by employing a convolutional neural network and support vector machine (CNN-SVM) hybrid model to classify diseases in four economically important crops: strawberries, peaches, cherries, and soybeans. The objective is to categorize 10 classes of diseases, with six diseased classes and four healthy classes, for these crops using the deep learning-based CNN-SVM model. Several pre-trained models, including VGG16, VGG19, DenseNet, Inception, MobileNetV2, MobileNet, Xception, and ShuffleNet, were also trained, achieving accuracy ranges from 53.82% to 98.8%. The proposed model, however, achieved an average accuracy of 99.09%. While the proposed model's accuracy is comparable to that of the VGG16 pre-trained model, its significantly lower number of trainable parameters makes it more efficient and distinctive. This research demonstrates the potential of the CNN-SVM model in enhancing the accuracy and efficiency of plant disease classification. The CNN-SVM model was selected over VGG16 and other models due to its superior performance metrics. The proposed model achieved a 99% F1-score, a 99.98% Area Under the Curve (AUC), and a 99% precision value, demonstrating its efficacy. Additionally, class activation maps were generated using the Gradient Weighted Class Activation Mapping (Grad-CAM) technique to provide a visual explanation of the detected diseases. A heatmap was created to highlight the regions requiring classification, further validating the model's accuracy and interpretability.
A multidimensional strategy for uncovering comprehensive quality markers of Scutellariae Radix based on UPLC-Q-TOF-MS analysis, artificial neural network, network pharmacology analysis, and molecular simulation
Authors: Liu Meiqi , Zhao Xiaoran , Wen Jinli , Sun Lili , Huang Rui , Zhang Huijie , Liu Yi , Ren Xiaoliang
Published: July 2024

Introduction

Scutellariae Radix (SR), derived from the root of Scutellaria baicalensis Georgi, is a traditional Chinese medicine (TCM) for clearing heat and cooling blood. It has been used as a traditional herbal medicine and is popular as a functional food in Asian countries today.

Methods

In this study, UPLC-Q-TOF-MS was first employed to identify the chemical components in the ethanol extract of SR. Then, the extraction process was optimized using star point design-response surface methodology. Fingerprints of different batches and processed products were established, and chemical markers were screened through a combination of various artificial neural network models. Finally, network pharmacology and molecular simulation techniques were utilized for verification to determine the quality markers.

Results

A total of 35 chemical components in SR were identified, and the optimal extraction process was determined as follows: ultrasonic extraction with 80% methanol at a ratio of 120:1 for 70 minutes, with a soaking time of 30 minutes. Through discriminant analysis using various artificial neural network models, the samples of SR could be classified into two categories based on their growth years: Kuqin (dried roots of older plants) and Ziqin (roots of younger plants). Moreover, the samples within each category could be further clustered according to their origins. The four different processed products of SR could also be distinguished separately. Finally, through the integration of network pharmacology and molecular simulation techniques, it was determined that baicalin, baicalein, wogonin, norwogonin, norwogonin-8-O-glucuronide, skullcapflavone II, hispidulin, 8, 8"-bibaicalein, and oroxylin A-7-O-beta-D-glucuronide could serve as quality markers for SR.

Discussion

The primary factors affecting the quality of SR were its growth years. The geographic origin of SR was identified as a secondary factor affecting its quality. Processing also had a significant impact on its quality. The selected quality markers have laid the foundation for the quality control of SR, and this research strategy also provides a research paradigm for improving the quality of TCM.
The effect of type of task on EFL learners’ vocabulary learning
Authors: Eskandari Zahra , Khatin-Zadeh Omid , Farsani Danyal , Banaruee Hassan
Published: July 2024

Depth of processing vocabulary has been the subject of heated discussion among vocabulary researchers. Yet, current literature lacks research comparing different tasks to investigate the acquisition of vocabulary knowledge among adult learners of English as a foreign language (EFL). To fill the gap, we designed five task-based groups based on Technique Feature Analysis (TFA) as a framework to predict the effectiveness of different vocabulary learning tasks with similar or different TFA rankings on L2 vocabulary knowledge gain. The participants were 130 EFL learners (mean age = 21.7, female 61.5%) randomly assigned to the vocabulary learning tasks: reading and multiple-choice items (TFA = 6), reading and choosing definitions (TFA = 6), reading and fill-in-the-blanks (TFA = 7), reading and rewording the sentences (TFA = 6) and composition writing (TFA = 8). The results of the study revealed that tasks with the same TFA scores led to similar vocabulary knowledge gains. While predictions of the TFA are partially supported, composition writing and sentence rewording tasks supersede other tasks in terms of their effectiveness in vocabulary acquisition.
Young people on social media in a globalized world: self-optimization in highly competitive and achievement-oriented forms of life
Authors: Butler Stephen
Published: July 2024

Research investigating young people’s social media use has been criticized for its limited theoretical foundations and scope. This paper elaborates young people’s social media activity from a socio-ecological evolutionary perspective (SEE), where young people’s online exchanges cannot be divorced from the highly competitive and achievement-oriented modern market cultures in which they live. In highly competitive and achievement-oriented forms of life, young people’s social media environments are often constituted as dynamic and evolving extrinsically oriented ecological niches that afford for status and identity enhancement while also affording for peer approval, belongingness, and self-worth nested within, and subordinate to, these higher-order affordances. The extrinsic value organization of social media platforms that serve young people’s status and identity-enhancement are embodied by a community of mutually interdependent criteria that are evolutionary-based, developmentally salient, and market-driven: physical attractiveness, high (educational and extracurricular) achievements, and material success. Young people’s online signaling of these interdependent extrinsic criteria affords for status-allocation and self-enhancement, where each criteria becomes an arena for social competition and identity formation, enabling young people to build personal and optimal models of social success congruent with their own interests and abilities. Young people’s status and identity enhancing signaling of these extrinsic criteria is moving toward increasingly idealized or perfect embodiments, informed by accelerating, short-term positive feedback processes that benefit from the technological affordances and densely rewarding peer environments instantiated on social media.
The unintended consequences of school-based health and nutrition policies: a systematic review
Authors: Turner Samantha L. , Libert Alexis M. , Haase Grace , Pan Zhaoyi , Austin Andrew , Timko C. Alix
Published: July 2024

Background

Significant funding and attention are directed toward school-based health and nutrition interventions. Less attention is given to the potential unintended consequences of these policies, especially those that target children and adolescents. This systematic review aimed to elucidate the unintended consequences of school-based health and nutrition policies in the United States.

Methods

We conducted a systematic review, adhering to PRISMA guidelines, to analyze quantitative, qualitative, and mixed methods research conducted between January 2013 and September 2023. The search strategy encompassed three databases, identifying 11 articles that met the inclusion criteria.

Results

Unintended consequences were organized into four themes: disordered weight control behaviors, parental discomfort or encouragement of disordered weight control behaviors, eating disorder triggers, and financial losses. The analysis of disordered weight control behaviors indicates limited impact on youth, and we noted limited consensus in the assessment of these behaviors. We observed parent concerns about BMI screening and reporting as well as apprehensions about privacy and efficacy. There were fewer articles addressing eating disorder antecedents, although there was evidence that some youths with eating disorders considered school health class a trigger of their disorder. One study was identified that found an increase in food waste following replacement of sugar-sweetened beverages.

Implications

Findings underscore the importance of comprehensive evaluation and consideration of unintended consequences in the development and implementation of school-based health policies. Recommendations include further longitudinal research, integrating obesity prevention with eating disorder prevention, and de-implementation when unintended consequences potentially outweigh benefits, such as in BMI screening and surveillance.

Systematic Review Registration: Identifier CRD42023467355. https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=467355
Postoperative factors associated with psychological well-being of living kidney donors: results of a retrospective and qualitative study
Authors: Galani Vasiliki , Mazzola Viridiana , Prada Paco , Bondolfi Guido
Published: July 2024

Introduction

Kidney transplantation from a living donor is the treatment of choice for end- stage kidney disease. Psychological implications of living kidney donation are of great importance, both during preliminary psychiatric assessment and post-donation follow-up. The identification of risk factors worsening the psychological well-being of living kidney donors (LKDs), before and after donation, remains challenging in terms of research.

Methods

At the University Hospitals of Geneva (HUG), our clinical observations and practice compelled us to establish post-donation follow-ups for LKDs at 6 months and 1 year. Pre-and post-donation sociodemographic, physical, psychological, and psychiatric data was collected from the medical records of 115 LKDs who underwent a complete physical and psychological evaluation during the period 2011-2018. We tested for any potential association between the variables under study.

Results

A qualitative and retrospective analysis of this data highlighted the impact of postoperative factors, such as pain, fatigue, recipient-donor relationship, and fulfillment of donors’ expectations, on the post-donation psychological well-being of LKDs.

Discussion

With regard to these findings, regular post-donation follow-ups, optimal care of postoperative pain and fatigue, as well as a solid therapeutic alliance with LKDs remain key points for clinicians involved in the dynamic process of living kidney donation.
“Close your eyes and relax”: the role of hypnosis in reducing anxiety, and its implications for the prevention of cardiovascular diseases
Authors: Leo Donato Giuseppe , Keller Simon S. , Proietti Riccardo
Published: July 2024

Anxiety is the most common form of mental health disorder, affecting millions of people worldwide. Psychosocial interventions such as mindfulness and cognitive behavioral therapy (CBT) have been suggested as an effective treatment in the management of general anxiety and anxiety disorders, with emerging evidence also suggesting the effectiveness of hypnosis. Moreover, anxiety has shown to be linked to the onset and development of several cardiovascular diseases (CVD), which are the leading cause of global death. In this paper, we review the current literature to examine the role that anxiety has on the onset and development of CVD and summarize the current knowledge on the role that hypnosis and hypnotherapy have in reducing anxiety, also explaining how this can impact the cardiovascular system and the prevention of CVD. Review of the evidence suggests that hypnosis and hypnotherapy are effective in treating anxiety and may positively affect the heart and the cardiovascular system, reducing sympathetic activation and increasing parasympathetic tone, potentially preventing the onset of CVD related to increased sympathetic activation. However, further studies are required to further understand how hypnosis and hypnotherapy affect the cardiovascular system through investigation of the neurophysiological components of the hypnotic state and of the mind-body relationship. Healthcare systems should embed mental health screening in patients at risk of developing CVD as part of the clinical pathway and consider the role that hypnosis and hypnotherapy may play in the management of CVD.
Emotionally-oriented design in museums: a case study of the Jewish Museum Berlin
Authors: Zhang Zhihui , Lu Jing , Zhang Xiuying
Published: July 2024

Objective

This study examines the intricate interplay between architectural design and visitor emotional responses at the Jewish Museum Berlin, focusing on how specific spatial elements such as the Holocaust Tower, Garden of Exile, The Voids, and The Axis elicit varied affective experiences. The research aims to extend the discourse on environmental psychology and architectural empathy, particularly within the context of memorial museums.

Method

Employing a non-intrusive approach, the study gathered emotional response data using the Positive and Negative Affect Schedule (PANAS) from 113 museum visitors, with 102 valid responses analyzed. Environmental conditions such as light, sound, and spatial design were quantitatively measured to correlate with emotional responses captured at the end of visitors' tours across the designated museum spaces.

Results

Findings revealed that architectural elements significantly influence emotional responses. High levels of negative emotions like fear and anxiety were markedly evident in the Holocaust Tower due to its minimal lighting and stark concrete structure. Conversely, the Garden of Exile induced more positive emotions through its use of natural light and greenery, emphasizing the role of biophilic design in enhancing emotional well-being. Statistical analysis supported these observations, with variations in emotional impact across different spaces demonstrating the profound effect of architectural design on visitor experiences.

Conclusion

This study confirms that a variety of design elements and spatial strategies not only facilitate the presentation of historical narratives but also actively sculpt the emotional involvement and experiences of visitors. Our findings highlight the efficacy of emotionally-oriented architectural design in deepening the impact and engagement of museum visitors, emphasizing the transformative power of these environments in shaping visitor perceptions and interactions.
Role of frailty in predicting outcomes after stroke: a systematic review and meta-analysis
Authors: Li Jing , Wan Jinping , Wang Hua
Published: July 2024

Background

Stroke is considered the second most common cause of death and the third leading cause of disability worldwide. Frailty, characterized by increased vulnerability to stressors, is emerging as a key factor affecting outcomes in older adults and stroke patients. This study aimed to estimate the prevalence of frailty in acute stroke patients and assess its association with mortality and poor functional outcome.

Methods

Medline, Google Scholar, and Science Direct databases were systematically searched for English-language studies that included adult stroke patients (>16 years), have defined frailty, and reported mortality and functional outcomes. Meta-analysis was done using STATA 14.2, and the results were expressed as pooled odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity was assessed using the I2 statistic and the Chi-square test. Study quality was evaluated using the Newcastle Ottawa Scale (NOS).

Results

Twenty-five studies were included in the analysis. Frailty prevalence in stroke patients was 23% (95% CI 22% - 23%). Unadjusted analysis showed an OR of 2.66 (95% CI: 1.93 - 3.67) for mortality and 2.04 (95% CI: 1.49 - 2.80) for poor functional outcome. Adjusted estimates indicated an OR of 1.22 (95% CI: 1.1 - 1.35) for mortality and 1.21 (95% CI: 1.04 - 1.41) for poor functional outcome, with substantial heterogeneity for both adjusted and unadjusted analyses. No publication bias was detected for the prevalence of frailty. However, there was a publication bias for the association between frailty and mortality.

Conclusions

Frailty was significantly associated with increased mortality and poorer functional outcomes in stroke patients. Our study highlights the need to focus on frailty in stroke patients to improve outcomes and quality of life. Further research should aim to standardize assessment of frailty and reduce heterogeneity in study outcomes.

Systematic review registration

https://www.crd.york.ac.uk/prospero/#searchadvanced, CRD42023470325.
The effect of virtual reality simulation on nursing students’ communication skills: a systematic review and meta-analysis
Authors: Cho Mi-Kyoung , Kim Mi Young
Published: July 2024

Virtual reality simulation (VRS) allows individuals to experience a sense of presence in a virtual environment, and it has been increasingly adopted as a novel teaching method in nursing education. VRS can have positive effects, such as patient safety, privacy assurance in healthcare, and enhanced interest and immersion in education. It is important to synthesize the results to date to determine if VRS has the potential to improve communication skills in practical nursing students. This systematic literature review and meta-analysis investigated the effect of VRS on the enhancement of communication skills among nursing students. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were employed for systematic review and meta-analysis. The following “PICO” details were considered: population—nursing students, intervention—VRS targeting communication skills enhancement, comparator—control groups without intervention or those undergoing general classes, and outcomes—communication skills. The search strategy yielded 301 results from nine databases, and 10 studies were selected for inclusion in our analysis. To calculate the overall effect sizes of the primary and secondary outcomes in the included studies, we used MIX 2.0 Pro (Version 2.0.1.6, BiostatXL, 2017) for the meta-analysis. The overall effect size for communication skills was 0.44, signifying a significant effect. A meta-regression analysis examining communication skills revealed significant results for the following factors: Fund (Ref.: No), outcome measurement time (Ref.: Immediately), outcome follow-up (Ref.: No), and debriefing (Ref.: No). Considering factors such as variations in sample size, research approaches, and the effects of independent studies on communication skills, this systematic literature review and meta-analysis suggests that VRS significantly improves nursing students’ communication skills overall.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier CRD42023439064.
Exploring the relationship between YouTube video characteristics and a viewer’s mental health traits among young adults
Authors: Choi Go Eun , Pyun Miran , Yoon So-Hee , Kim Yeongchae , Shin Hyejin , Lee Sang Yup
Published: July 2024

We investigated the relationship between individuals’ mental health traits and the characteristics of YouTube videos they watch. The mental health traits considered were stress, depression, anxiety, and self-esteem, which were measured using a survey questionnaire. We considered violence shown in a video, brightness and saturation of a video as video characteristics. We utilized the viewing history log data of the participants and analyzed the videos they watched on YouTube using computer vision techniques based on deep learning algorithms. The results revealed that viewers’ consumption of violent videos was positively related to stress, depression, and anxiety, but negatively related to self-esteem. Individuals with higher levels of stress, depression, or anxiety tended to view darker videos than those with lower levels of stress, depression, or anxiety.
The relationship between university student help-seeking intentions and well-being outcomes
Authors: McCabe Melinda , Byrne Michelle , Gullifer Judith , Cornish Kim
Published: July 2024

University represents a time of both great uncertainty and change as well as a time of opportunity and learning. University students represent a population both at a higher risk of experiencing poor mental health and diagnosis and a population with relatively greater access and communication of both mental health literacy resources and mental health support services. Despite this, we consistently see low intention of help-seeking for mental health services or health services, with a clear preference shown for personal contacts such as friends or parents. To understand help-seeking intentions and their relationship with well-being, the current study explored two core hypotheses, when assessing a broad range of help-seeking options, the likelihood of seeking support from a range of sources will cluster together to create help-seeking groupings that can be further explored (1) and that across these help-seeking factors, there would be difference in intention score across students who fall within “at-risk,” “low,” or “normal to high” well-being groupings (2). Through a series of exploratory factor analysis (EFA) on a subsample (N = 178) and final confirmatory factor analysis (N = 1597) identified five help-seeking factors: Intimate Partner (single item), Personal Relations (friends, parents, and other relatives), External Health Service (external mental health provider and health provider), University Health Service (university mental health and health provider), and Digital and Distal Professional (digital apps, websites or forums, telehealth, religious leaders, and phone or online emergency services). To address hypothesis 2, a multivariate analysis of covariance was run to assess help-seeking intentions across factors between students with “at-risk” (N = 453), “low” (N = 484), or “normal to high” (N = 563) well-being scores. Although significant differences were found between groups on almost all help-seeking factors (except External Health Service), the differences between groups were small. However, consistently those with “normal to high” well-being demonstrated higher intention to seek help compared to “low” and “at-risk” groups. Across all groups, Personal Relations demonstrated the highest average help-seeking intention score and, in addition to supporting findings in previous literature, represents a potential “lowest hanging fruit” of help-seeking source for university students.
Impact of epidemic prevention policies on public vaccination willingness: empirical research in China
Authors: Zhong Jie , Zhuang Yue , Zhang Miao
Published: July 2024

Background

The sudden emergence of the COVID-19 pandemic in early 2020 posed an enormous threat to public health. Vaccination is currently recognized as the most cost-effective preventive and control measure against the COVID-19 pandemic worldwide and is the key to constructing a line of defense against the virus, while the epidemic prevention policies adopted by governments have an important impact on the protective behavior of the public. The purpose of this study is to analyze the mechanism by which the stringency of epidemic prevention policies affects public vaccination willingness and to explore the mediating effect of public risk perception.

Methods

A cross-sectional survey was conducted among 387 adults from December 2022 to June 2023 in China. A multiple linear regression model was used to explore the impact of epidemic prevention policy stringency on public vaccination willingness, and a hierarchical regression model was used to test the mediating effect of public risk perception.

Results

Our results showed that public vaccination willingness increased by approximately 45.5% for every one-unit increase in the stringency of the epidemic prevention policies, which shows that the stringency of epidemic prevention policies has a significant positive influence on public vaccination willingness. In addition, public risk perception increased by approximately 38.9% during the period of stringent government policies on epidemic prevention. For every one-unit increase in risk perception, public vaccination willingness increased by approximately 40.9%, and the relationship between the stringency of epidemic prevention policies and public vaccination willingness was partially mediated by risk perception.

Conclusion

The stricter the epidemic prevention policies, the stronger the public vaccination willingness; risk perception plays a mediating effect between the stringency of epidemic prevention policies and public vaccination willingness. This finding is particularly important for exploring and analyzing the factors influencing public vaccination willingness and for improving public health.
Mediating mechanism of posttraumatic growth as buffers of burnout and PTSD among nurses during the COVID-19 pandemic
Authors: Sim Jae-Chang , Cha Sun-Kyung , Im Sun-Young
Published: July 2024

Objective

The study aims to investigate factors that prevent burnout (BO) and symptoms of posttraumatic stress disorder (PTSD) while facilitating posttraumatic growth (PTG) among nurses combating the coronavirus disease 2019 (COVID-19) pandemic, with the purpose of validating the mediating effects of PTG.

Methods

A total of 247 nurses who provided patient care during the COVID-19 pandemic were enrolled, and a questionnaire was used to measure BO, PTSD, and PTG, data on deliberate rumination, emotional expression, adaptive cognitive emotion regulation (CER), maladaptive CER, and social support. The mediation path models for the effects of the predictors on BO and PS through the mediation of PTG were analyzed using the R Lavaan package.

Results

The results showed that deliberate rumination, emotional expression, and adaptive CER significantly increased PTG, while PTG significantly reduced BO and PTSD symptoms (PSs). However, maladaptive CER did not have a significant effect on PTG and only had significant direct effects on BO and PS. Bootstrapping confirmed that PTG significantly mediated the effects of all predictors. It partially mediated the effects of deliberate rumination and adaptive CER and completely mediated the effects of emotional expression.

Conclusion

Based on the results, it has been supported that deliberate rumination, emotional expression, and adaptive CER should be addressed as important variables in psychological interventions addressing nurses’ adversities during the pandemic. These variables can prevent BO and PS by facilitating PTG.
Association of heavy metals exposure with lower blood pressure in the population aged 8–17 years: a cross-sectional study based on NHANES
Authors: Liang Yongzhou , Zhang Minjie , Jin Wenhao , Zhao Liqing , Wu Yurong
Published: July 2024

Background

The existing evidence regarding the joint effect of heavy metals on blood pressure (BP) in children and adolescents is insufficient. Furthermore, the impact of factors such as body weight, fish consumption, and age on their association remains unclear.

Methods

The study utilized original data from the National Health and Nutrition Examination Survey, encompassing 2,224 children and adolescents with complete information on 12 urinary metals (barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, tungsten, uranium, mercury and arsenic), BP, and core covariates. Various statistical methods, including weighted multiple logistic regression, linear regression, and Weighted Quantile Sum regression (WQS), were employed to evaluate the impact of mixed metal exposure on BP. Sensitivity analysis was conducted to confirm the primary analytical findings.

Results

The findings revealed that children and adolescents with low-level exposure to lead (0.40 μg/L, 95%CI: 0.37, 0.42), mercury (0.38 μg/L, 95%CI: 0.35, 0.42) and molybdenum (73.66 μg/L, 95%CI: 70.65, 76.66) exhibited reduced systolic blood pressure (SBP) and diastolic blood pressure (DBP). Conversely, barium (2.39 μg/L, 95%CI: 2.25, 2.54) showed a positive association with increased SBP. A 25th percentile increase in the WQS index is significantly associated with a decrease in SBP of 0.67 mmHg (95%CI, −1.24, −0.10) and a decrease in DBP of 0.59 mmHg (95% CI, −1.06, −0.12), which remains statistically significant even after adjusting for weight. Furthermore, among individuals who consume fish, heavy metals have a more significant influence on SBP. A 25 percentile increase in the WQS index is significantly associated with a decrease of 3.30 mmHg (95% CI, −4.73, −1.87) in SBP, primarily attributed to mercury (27.61%), cadmium (27.49%), cesium (17.98%), thallium (8.49%). The study also identified a declining trend in SBP among children aged 10–17, whereas children aged 11–18 exhibited lower levels of systolic and diastolic blood pressure, along with a reduced risk of hypertension.

Conclusion

Some heavy metals demonstrate an inverse association with the BP of children and adolescents, particularly notable in groups with fish consumption and older children and adolescents. Future studies are warranted to validate these findings and delve deeper into the interplay of heavy metals.
Congenital dyserythropoietic anemia type II and ineffective erythropoiesis: challenges in diagnosis and management
Authors: Akpan Imo J. , Bogyo Kelsie , Leeman-Neill Rebecca J. , Wattacheril Julia , Francis Richard O.
Published: July 2024

Congenital dyserythropoietic anemia (CDA) is characterized by anemia—mild to severe, hemolysis, ineffective erythropoiesis, and in some cases, iron overload. There are three major types of CDA (I, II, and III), and the other types are rarer. The rarity of this disease, as well as signs and symptoms that overlap with other hematological diseases, can make the diagnosis difficult and delayed over several years. Evaluation includes basic laboratory testing, magnetic resonance imaging of organs for assessment of iron overload, bone marrow assessment, and genetic testing. Laboratory tests to evaluate for ineffective erythropoiesis include indirect bilirubin level, which can be normal or increased, reticulocyte production index < 2 signifying hyperproliferation of erythrocytes, and complete iron panel (serum iron, ferritin, and iron saturation), which may suggest iron overload. Genetic testing is crucial for CDA diagnosis and includes next-generation sequencing. A multidisciplinary team of providers including a hematologist, hepatologist, hematopathologist, and genetic counselor are important and sometimes necessary for the evaluation, diagnosis, and management of these patients. Management depends on the clinical phenotype, and some severe cases may require blood transfusion, iron chelation therapy, splenectomy, and in extreme cases, hematopoietic stem cell transplant may be necessary. This mini-review illustrates the challenges involved in the diagnosis and management of the most common CDA, which is type II. It will highlight clinical signs and symptoms in patients that should prompt providers to test for CDA. It will also increase awareness of this disease, discuss possible barriers to testing, and provide guidance on how to manage the disease.
Urban human needs: conceptual framework to promoting urban city fulfills human desires
Authors: Alsayed Shaimaa S.
Published: July 2024

Cities have been created to meet human needs, but creating sustainable societies has become a major challenge in light of the planners’ broad interest in creating smart cities or giving exclusive priority to the environmental dimension of sustainability. This is one of the goals related to sustainable development (SDGs) and therefore, the human perspective of urbanism is considered a future challenge in achieving (SDGs). The research aims to bridge the gap in previous studies and highlight the integration of human needs in plans for urban human cities. It also aims to create a conceptual framework that leads to a new theory of urban needs by bridging the knowledge gap in previous studies by considering modern numerical analysis tools, Thus, a bibliometric analysis based on the Biblioshiny and VOSviewer tools within the scope of human needs and urban cities promotion was accomplished. Next selecting evaluation criteria for human needs through a comparative critique of the most important theories of human needs. Then deducting the new theory of urban needs and linking it to the elements of urban composition. Results have reached a new framework that clarifies the human needs that need to be achieved and links them to the urban components to create an integrated urbanization that fulfills the desires of the population. This research serves as a reference for reevaluating urban directions and modern theories that aim to develop future cities. It also helps evaluate cities, envision future human needs, and achieve future prosperity for cities.
Use of galvanic vestibular stimulation device as a countermeasure for microgravity effects in spaceflight
Authors: Soto Enrique , Vega Rosario
Published: July 2024

This work discusses the challenges of space exploration, focusing on microgravity-induced physiological changes, particularly those affecting the vestibular system, which significantly alters human performance in space, necessitating effective countermeasures. In microgravity, astronauts experience disorientation and space motion sickness due to changes in vestibular input, leading to symptoms like vertigo and headache. Postflight, astronauts show various neurological changes, similar to symptoms in individuals with vestibular disorders experiencing significant cognitive and perceptual difficulties. Studies have also shown that microgravity affects cortical and sensory responses, altering perception, motor function, and brain connectivity. Galvanic Vestibular Stimulation (GVS) is explored as a countermeasure, using modulated electrical currents to evoke neuronal activity in vestibular end-organs, potentially stabilizing posture and gaze in microgravity. The work proposes that GVS could serve as a non-invasive intervention to help adapt to space environments by enhancing vestibular function and possibly aiding cognitive functions and underscores the need for continued research into the vestibular system’s role in human health and performance during space missions. It highlights the potential of GVS as a promising countermeasure for the challenges posed by microgravity.
Comparison of three device generations of the StepWatch Activity Monitor: analysis of model version agreement in pediatric and adult independent ambulators
Authors: Stevens Wilshaw R. , Barrett Cody , Jeans Kelly A.
Published: July 2024

Purpose

Devices such as the StepWatch Activity Monitor (SAM) have been available for 20 years and have been shown to accurately measure ambulatory activity. This study aimed to evaluate the agreement among the three generations of the StepWatch Activity Monitor (SW3, SW4, and SW5) with respect to stride count.

Methods

A total of 36 participants (age range, 6–55 years) participated in this institutional review board-approved study. The participants concurrently wore three different SAM model devices on the same leg and performed a 6-min walk test (6MWT). A research staff member of the laboratory manually counted the number of strides for the first 2 min of the test (2MWT). Agreement among the device models was evaluated by calculating ANOVAs and interclass correlation coefficients (ICCs) and creating Bland–Altman plots.

Results

There was no significant difference among the model versions during the 6MWT and 2MWT (p > 0.05). The ICC for the total stride count was 0.993 (95% CI = 0.988–0.996) during the 2MWT and 0.992 (95% CI = 0.986–0.996) during the 6MWT. There was a near-perfect agreement (ICC ≥ 0.990) of each model version to the manually counted strides during the 2MWT. The systematic bias of all three SAM model versions was <1 step.

Conclusions

The results from the present study demonstrate that the stride counts among all three devices are comparable and relative to the manual stride count. All three SAM model versions had an ICC of >0.90. Researchers can safely incorporate historical data from previous SAM model versions with newer data collected with the latest SAM model version.
Needle size for thyroid fine needle aspiration cytology. A single institution experience
Authors: Cianci Pasquale , Tumolo Rocco , Conversano Ivana , Travaglia Damiano , Trigiante Giuseppe , Lantone Giuliano , Lizzi Vincenzo , Cappiello Miriam , Montagna Marco , Curci Fabio Pio , Restini Enrico
Published: July 2024

Background

Fine needle aspiration cytology (FNAC) is an invasive diagnostic technique which is widely used for the cytological diagnosis of thyroid nodules. This procedure is generally widely tolerated by patients, albeit often accompanied by local pain and discomfort. Despite various proposals of execution methods, no approach is universally accepted,especially regarding the size of the needle to be used for sampling. Needle gauge preferences vary across regions, with 25-gauge needles more common in Western countries and 22-gauge needles favored in Asian countries. Complications associated with larger needles have been studied but remain inconclusive.

Materials and methods

Over one year, we conducted 300 FNAC procedures under ultrasound guidance, employing both 22-gauge and 25-gauge needles. In no patient was local anesthesia performed before starting the procedure, which in all was performed by the same operator. Similarly the cytological examination of the material taken was performed by a single operator. Patients, 105 males and 195 females, were divided into two groups of 150 each based on the needle size used.

Results

Patients treated with 22-gauge needles reported higher levels of pain during the procedure and increased discomfort afterward. Similarly, a greater incidence of hematomas and vasovagal reactions was noted in this group. However, the cell sample obtained and diagnostic response rates were consistent across both groups.

Conclusion

On the basis of our observations we concluded that the size of the needle used is irrelevant for the purposes of the diagnostic result, as long as the procedure is performed by expert personnel. However, the 25-gauge needle is preferable because it's more tolerated and accepted by patients. Our results do not represent a single and conclusive verdict, but they could represent the starting point for further research.
Postoperative opioid-free analgesia in dogs undergoing tibial plateau leveling osteotomy: a feasibility study
Authors: Didier Caroline , Faucher Sarah , Sarra Ferrer Marti , Lapouge Mathilde , Junot Stéphane , Jourdan Géraldine
Published: July 2024

Objectives

This study was designed to prospectively evaluate the feasibility of an opioid-free anesthesia protocol and describe the quality of recovery and management of postoperative analgesia in dogs after a tibial plateau leveling osteotomy (TPLO).

Methods

In total, 20 dogs presented for TPLO were included. After premedication with intravenous (IV) medetomidine (0.005–0.007 mg/kg) and midazolam (0.2 mg/kg), the dogs were anesthetized using ketamine (2 mg/kg) and propofol and maintained with isoflurane and ketamine CRI (0.6 mg/kg/h). Sciatic and femoral nerve blocks were performed with bupivacaine 0.5% (0.087 +/− 0.01 and 0.09 +/− 0.02 mL/kg, respectively). Meloxicam (0.2 mg/kg IV) was administered intraoperatively, after osteotomy. Fentanyl (0.002 mg/kg IV) was administered intraoperatively, as rescue analgesia in the case of sustained increase in cardiorespiratory variables. Two pain scores (French 4A-VET and Glasgow short form) were performed at conscious sternal recumbency and 2, 4, 6, 8, 12, and 20 h after extubation and compared to baseline using a Friedman test followed by a Nemenyi post-hoc test. The time taken for the first food intake and urination was reported.

Results

Intraoperative opioid-free anesthesia was feasible in 11 dogs, whereas 9 dogs received fentanyl once during arthrotomy. No opioid postoperative rescue analgesia was required. Food intake occurred within 6 h, and all dogs were discharged after 24 h without any complication.

Conclusion

Total opioid-free postoperative analgesia was achieved in all dogs, with adequate recoveries. Although opioid-free anesthesia was feasible in 55% of the population, a single dose of fentanyl was necessary in 45% of the dogs during arthrotomy.
Study on Heat Transfer Characteristics of Jet Impingement of Turbine Bending Surface
Authors: Zeng Fei , Sun Ruijia , Chen Zhenhua , Liu Yuang , Yang Weihua
Published: July 2024

The architecture of aeroengine air-cooling system channels is notably intricate, with impingement heat transfer standing out as a critical process amidst the complexity. This study delves into the casing annular cavity’s structure, examining the influence of flow and structural parameters on heat transfer characteristics. Experimental findings have revealed a trend towards more uniform temperature distributions across the impingement target plate as the relative impingement distance (H/d) increases, under a constant impingement Reynolds number (Rej). Notably, an impingement angle (β) of 90° yields optimal heat transfer effects on the target surface. Furthermore, a higher impingement hole consistency (Is) correlates with a lower and more uniform temperature distribution across the target plate. Additionally, escalating the crossflow ratio (mc/m) results in a decline in the temperature at the impingement stagnation point and a corresponding rise in the heat transfer coefficient.
Conversion Efficiency of 45.0% in InGaP/InGaAs/Ge Triple-Junction Solar Cells for Laser Power Beaming
Authors: Koga Masahiro , Shibui Shunsuke , Matsuoka Nozomi , Sudo Tomoya , Uchida Shiro
Published: July 2024

Optical wireless power transmission systems are attracting attention as a new power transmission technology because they can supply power wirelessly over long distances. In this study, we investigated InGaP/InGaAs/Ge triple-junction solar cells simultaneously irradiated with three laser beams with wavelengths of 635 nm, 850 nm, and 1550 nm to improve photoelectric conversion efficiency. As a result, a photoelectric conversion efficiency of 45.0% was obtained under three laser irradiations with a total incident laser power of 1.77 W/cm2. The results showed the possibility of a high-efficiency optical wireless power transmission system by simultaneously irradiating laser beams with different wavelengths onto multi-junction solar cells, which could be installed in automobiles as a new system that complements solar power generation for daylighting.