bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent Cellulitis Caused by a Hidden Abscess: A Case Report
Authors: Bang Chi , Lee Seung , Sung Kunyong , Jeong Chanho , Lee Sang-Yeul , Oh Suk
Published: December 2024

Background. Skin and soft tissue infections are commonly encountered in clinical practice, and they are typically responsive to antibiotics and drainage. In most cases, cellulitis can be diagnosed via physical examination by a health care professional, based on the typical appearance of the skin and on symptoms such as redness, swelling, warmth, and pain. However, persistent cellulitis or nonresolving abscesses may require in-depth evaluation. When encountering refractory skin and soft tissue infections, clinicians should consider factors such as nontuberculous mycobacterial infection, underlying osteomyelitis, foreign bodies, and malignancy, among other factors. Case Report. A 65-year-old male underwent 5 incision and drainage procedures at 2 different hospitals over 8 months without resolution of cellulitis. At the patient’s presentation to the hospital of the authors of the current report, the authors successfully identified and removed a hidden abscess pocket, resulting in healing. Conclusion. In cases of recurrent skin and soft tissue infections that are unresponsive to standard treatments, preoperative imaging and hematologic studies are crucial to exclude underlying causes such as malignancy, atypical infections, foreign bodies, osteomyelitis, and hidden abscesses outside the initial surgical field. The current case highlights the importance of a comprehensive intraoperative examination to identify and remove any hidden abscesses to aid in the successful resolution of chronic infection. This report highlights the importance of a thorough approach in managing intricate cases of skin and soft tissue infections when standard interventions are not successful.
Skin Failure Clinical Characteristics and Clinical Instruments for Diagnosis in Adult Patients With Advanced or Terminal Diseases: A Scoping Review
Authors: Zimmermann-Vildoso Melissa , Devia-González Javier , Nogueira Paula , de Brito Poveda Vanessa
Published: December 2024

Background. There is limited use of the term skin failure in the clinical setting; however, it is valid to question the differences between skin failure and other injuries (eg, pressure injuries). The evaluation of skin failure should be based on specific clinical characteristics to strengthen the knowledge of this phenomenon and to set standards of care. Objective. To evaluate the available evidence about characteristics of and clinical instruments for skin failure diagnosis and evaluation in adult patients with advanced or end-stage disease. Methods. Between April 4 and May 18 2023, a scoping review was conducted and included literature on skin failure classification and diagnosis in patients aged 18 years or older in any health context. Articles that included a pediatric population or dermatologic diagnoses not related to the current concept of skin failure and articles referring only to a theoretical definition of skin failure were excluded. The databases searched were PubMed, CINAHL, Web of Science, LILACS, ScienceDirect, and the Cochrane Database of Systematic Reviews. Grey literature was retrieved via the “DART E-theses Portal” and “CAPES Thesis Portal.” Results. A total of 196 articles were identified. The final sample included 8 studies related to the theoretical concept of skin failure. The most cited factors related to acute skin failure were sepsis, hypoperfusion, vasopressor use, oxygenation, nutritional status, acute organ compromise, mechanical ventilation, and chronic diseases. One specific tool was identified to assess skin failure that included the same characteristics revealed by this scoping review. Conclusion. There is limited evidence regarding clinical indicators for the evaluation of skin failure. The results of this exploratory review suggest specific clinical features of skin failure which may consider other elements than those related to pressure injuries. Primary studies are needed to strengthen the diagnosis of skin failure and its inclusion in routine health care practice at any stage of disease.
Total Capsulectomy and NPWT for Management of a Mycobacterium abscessus Breast Implant Infection Unresponsive to Antimicrobial Therapy: A Case Report and Literature Review
Authors: Cimmino Andrea , Marangi Giovanni , D’Onofrio Gianluca , Gratteri Marco , Porso Daniela , Romano Fara , Mirra Carlo , Persichetti Paolo
Published: December 2024

Background. Nontuberculous mycobacteria (NTM) periprosthetic infections after breast augmentation procedures are increasingly common worldwide and should raise suspicion after empirical antimicrobial therapy fails but clinical signs of infection persist. In this case experience, the authors suggest the use of negative pressure wound therapy (NPWT) for NTM-infected wounds to obtain a faster periprosthetic space closure, shorten healing time, and anticipate breast reimplantation. Case Report. This case report describes the successful application of NPWT to manage wound healing after breast removal in a 60-year-old female who underwent secondary breast augmentation 7 years before. The patient presented with an M. abscessus infection of the left breast after lung segmentectomy that persisted post-implant removal and targeted antibiotic therapy. Based on clinical and laboratory findings, the authors opted for a debridement of the periprosthetic space associated to a radical capsulectomy. Application of NPWT for wound drainage and closure allowed a faster recovery, reduced interval from implant removal to reimplantation, and led to a pleasant cosmetic result. Conclusion. The use of NPWT for wound management after NTM peri-implant infection may help to encourage faster periprosthetic space drainage and closure, thus expediting the timing of a negative culture and breast reimplantation.
Characteristics of Stomata and Leaf Thickness in Several Liliales Plants
Authors: Hasan Rusdi , Nurzaman Mohamad , Setiawati Tia , Mutaqin Asep Zainal
Published: December 2024

This study examines the stomatal characteristics and leaf thickness of six species within the Liliales: Gloriosa superba, Sansevieria trifasciata, Aloe vera, Cordyline terminalis, Pleomele angustifolia, and Allium fistulosum. Stomatal density, type, and distribution were measured to understand their relationship with leaf morphology. The results show that Gloriosa superba has a stomatal density of 148.72/mm² and an index of 0.295, with thin leaves. Sansevieria trifasciata, with its thick, fleshy leaves, has a lower stomatal density of 15.39/mm² and an index of 0.031. Aloe vera, another species with thick leaves, has a stomatal density of 38.47/mm² and an index of 0.067. In contrast, Cordyline terminalis and *Pleomele angustifolia, which have thin leaves, exhibit higher stomatal densities of 192.31/mm² and 128.21/mm², respectively. Their stomatal indices are 0.092 for Cordyline terminalis and 0.163 for Pleomele angustifolia. Allium fistulosum also has thin leaves, with a stomatal density of 100/mm² and a high stomatal index of 0.390. The study reveals that species with thicker leaves tend to have lower stomatal densities, a feature that helps reduce water loss in arid environments. These findings contribute to a deeper understanding of plant adaptation mechanisms and have implications for improving water-use efficiency in agriculture and conservation efforts.
Growth Pattern and Condition Factors of Kurisi Fish (Nemipterus nematophorus, Russel 1990) Landed at Lempasing Fishing Port
Authors: Nindia Ciandra Niawati  , Putriani Rizha Bery
Published: December 2024

The kurisi fish (Nemipterus nematophorus) is one of the demersal species caught at PPP Lempasing using purse seine nets. This study aims to obtain information about the growth patterns and condition factors of kurisi fish found in the waters of Teluk Lampung and landed at PPP Lempasing. The methods employed include direct data collection through random sampling of fish, where analysis is conducted to identify the relationship between length and weight as well as the condition factor of the fish. The results indicate that the total catch of kurisi fish reached 350 individuals, with total lengths ranging from 140 to 256 mm, categorized into 9 length classes. The growth pattern of kurisi fish is characterized as negative allometric, with a value of b equal to 2.4405, indicating that the length of the fish grows faster than its weight. The average condition factor of kurisi fish is 0.9763, suggesting that these fish have a flattened body shape.
Feasibility Analysis of Illustrated Concept Map-Based Handouts on Plant and Animal Organ System Material
Authors: Diana Erna , Mulyadi
Published: December 2024

Teaching materials at MAS Al-Manar are limited to printed books, which hinders students' access to a variety of learning sources, particularly in abstract Biology topics. The research aimed to analyze the feasibility test of Handouts Based on Illustrated Concept Maps on Plant and Animal Organ System Material at MAS Al-Manar Aceh Besar. The research utilizes an Research and Development (R&D) model with a Borg and Gall research design. The research sample consisted of two media experts and two material experts. Data collection instruments include media feasibility test sheets and material feasibility test sheets. Analysis of feasibility data utilizes a percentage formula. The experts' media and material feasibility tests resulted in an average percentage of 83.5%, placing them in the highly feasible category. Based on the results of media and material feasibility tests, it can be concluded that the Handout is Based on Illustrated Concept Maps on Plant and Animal Organ System Material at MAS Al-Manar Aceh Besar.
Purslane Herb (Portulaca grandiflora) Ointment Antibacterial Potency against Staphylococcus aureus
Authors: Purwanto Agus , Budiawan Antonius , Nugroho Christianto Adhy , Indriasari Christina
Published: December 2024

Recent research showed that the rose-like purslane (Portulaca grandiflora) magenta flower variety herbs ethanolic extract has antimicrobial potency. This research aims to determine the purslane herbs (Portulaca grandiflora) extract ointment antimicrobial potency against Staphylococcus aureus. Ointment base formulation contained of vaseline album, cera alba, adeps lanae, paraffin liquidum, cetyl alcohol, nipagin, and nipasol. Extract ointment was prepared by mixing the extract with 10, 20, and 30% concentrations into the ointment base. The antimicrobial activity test conducted in vitro using the paperdisk difussion method. The antimicrobial activity test result of the three extract concentrations of ointments showed that the 30% extract ointment had antimicrobial effect on Staphylococcus aureus with 0.81±0.03cm of clear zone. The antimicrobial activity test demonstrated that 30% purslane herbs (Portulaca grandiflora) extract ointment has a potency as antimicrobial against Staphylococcus aureus.
MECHANISMS AND MARKERS OF ACUTE MULTI-WALLED CARBON NANOTUBES-INDUCED INTOXICATION IN RATS
Authors:   Yanka Kupala State University of Grodno, Grodno, Belarus, Ilyich T. V. , Savko A. I. ,   Yanka Kupala State University of Grodno, Grodno, Belarus, Kavalenia T. A. ,   Yanka Kupala State University of Grodno, Grodno, Belarus, Klimovich I. I. ,   Grodno State Medical University, Grodno, Belarus, Zavodnik I. B. ,   Yanka Kupala State University of Grodno, Grodno, Belarus
Published: December 2024

Background. Being the products of modern nanomanufacturing carbon nanotubes exhibit high surface reactivity, outstanding chemical, optical, and electrical properties, as well as high toxicity. Objective. To determine the effects and markers of carbon nanoparticle – induced intoxication in experimental rats, liver mitochondria being the main target of the exposure. Material and methods. Acute intoxication in rats was induced by a single injection of multilayer carbon nanotubes (diameter 50–90 nm) at a dosage of 50 mg/kg. We measured bilirubin and aminotransferase blood plasma levels, oxidative stress level, respiratory activity as well as membrane potential of rat liver mitochondria. Results. We did not reveal significantly elevated blood plasma levels of liver damage markers (bilirubin and aminotransferase activity levels), but detected erythrocyte oxidative stress due to carbon nanotube–induced intoxication. The toxic effect did not change the respiratory activity and membrane potential of rat liver mitochondria. Conclusion. Acute toxic effect of nanoparticles did not cause elevation either in blood plasma levels of liver damage markers or of the activity of liver mitochondria, but increased the sensitivity of mitochondria to calcium ions. It can be assumed that large hydrophobic carbon nanotubes are not readily absorbed and distributed in tissues after single administration in rats.
АССОЦИАЦИЯ ПОЛИМОРОФИЗМА ГЕНA КОСТНОГО МОРФОГЕНЕТИЧЕСКОГО БЕЛКА ВМР-15 С УРОВНЕМ ТИРОКСИНА В КРОВИ У ОВЕЦ РОМАНОВСКОЙ ПОРОДЫ
Authors: Тарасенко Е.И. , Климанова Е.А.
Published: December 2024

Методы геномной селекции в настоящее время применяется в овцеводстве для выявления генетических маркеров, связанных с мясными характеристиками, качеством шерсти и устойчивостью к заболеваниям. Уникальные адаптивные способности некоторых пород овец требуют изучения их генетических и фенотипических особенностей с учётом иммуногенетического статуса. Цель данной работы – оценка ассоциации полиморфизма гена костного морфогенетического белка ВМР-15 с содержанием тироксина в крови у овец романовской породы в условиях Западной Сибири. Исследование проведено на баранах романовской породы в возрасте 4-х мес. Для молекулярно-генетических и биохимических исследований использовалась кровь, полученная методом вакуумной экстракции. Уровень тироксина в сыворотке крови определяли методом иммуноферментного анализа, ДНК выделяли с использованием набора от компании «Биолабмикс».. Выявлена статистически значимая ассоциация полиморфизма гена BMP-15 с уровнем тироксина в крови. У гомозиготных животных с генотипом WW уровень тироксина в 1,3 раза выше, чем у гомозигот MM. Сила влияния генотипа по локусу BMP-15 на содержание тироксина в крови составило 9,5% (P<0.01). Заключили, что анализ полиморофизма локуса ВМР-15, как показателя многоплодия у овец романовской породы, может привести в дальнейшем к отбору животных желательных генотипов и, соответственно, к увеличению плодовитости и ускорению селекционного процесса.

Methods of genomic selection are currently used in sheep breeding to identify genetic markers associated with meat characteristics, wool quality and resistance to diseases. Unique adaptive abilities of some sheep breeds require studying their genetic and phenotypic features taking into account the immunogenetic status. The purpose of this work is to evaluate the association of the polymorphism of the bone morphogenetic protein BMP-15 gene with the level of thyroxine in the blood of Romanov sheep in the conditions of Western Siberia. The study has been performed on 4-month-old Romanov rams. Blood obtained by vacuum extraction was used for molecular genetic and biochemical studies. Serum thyroxine levels were determined by enzyme immunoassay, DNA was isolated using a commercially available kit from Biolabmix. A statistically significant association was found between BMP-15 gene polymorphism and blood thyroxine levels. Homozygous animals with the WW genotype had thyroxine levels 1.3 times higher than those of MM homozygotes. The effect of the BMP-15 genotype on blood thyroxine levels was 9.5% (P<0.01). It was concluded that analysis of BMP-15 locus polymorphism as an indicator of prolificacy in Romanov sheep may further lead to selection of animals with desirable genotypes and, accordingly, to increased fertility and acceleration of the breeding process.
Международно-правовые вопросы защиты подводного культурного наследия на примере спора между Испанией и Колумбией.
Authors: Демирчян Л.С.
Published: December 2024

В статье анализируется международно-правовое регулирование вопросов охраны подводного культурного наследия на примере спора между Испанией и Колумбией о принадлежности галеона «Сан-Хосе», затонувшего у берегов Колумбии в 1708 году. Рассматриваются международные акты, регламентирующие охрану подводного культурного наследия, а также законы, принятые в этой области Испанией и Колумбией. Автор предлагает свое видение возможностей урегулирования возникшего спора.

The article analyzes the international legal regulation of the protection of underwater cultural heritage on the example of a dispute between Spain and Colombia over the ownership of the San Jose galleon, which sank off the coast of Colombia in 1708. The international acts regulating the protection of the underwater cultural heritage, as well as the laws adopted in this area by Spain and Colombia, are considered. The author offers his own vision of the possibilities for resolving the dispute that has arisen.
К вопросу о предмете управленческого права
Authors: Костенников М.В. , Куракин А.В. , Адмиралова И.А. , Харитонов А.Н.
Published: December 2024

Рассматривается правовой феномен «право управления». Для раскрытия содержания данного понятия анализируется категории «государственное управление». Авторы представляют базовые элементы права управления, а также определяют предмет соответствующего направления правового регулирования. В завершение исследования авторы резюмируют, что право управления является важной частью административного права.

The legal phenomenon "right of management" is considered. To reveal the content of this concept, the category of "public administration" is analyzed. The authors present the basic elements of the right to manage, and also determine the subject of the corresponding direction of legal regulation. At the end of the study, the authors summarize that the right to manage is an important part of administrative law.
Практика рассмотрения споров по оспариванию подозрительных сделок юридических лиц.
Authors: Быков В.П. , Черникова Е.В. , Маркелова И.В.
Published: December 2024

Представленная вниманию читателя статья продолжает цикл авторских материалов о различных аспектах правового регулирования в сфере арбитражного судопроизводства. В статье рассматриваются вопросы, возникающие при рассмотрении арбитражными судами споров по оспариванию сделок юридических лиц на основании статьи 61.2 Закона о банкротстве. На основе исследованной арбитражной практики авторы анализируют ошибки, допускаемые при признании недействительными подозрительных сделок, совершаемых юридическими лицами.

The article presented to the attention of the reader continues the cycle of author's materials on various aspects of legal regulation in the field of arbitration proceedings. The article deals with issues that arise when arbitration courts consider disputes to challenge transactions of legal entities on the basis of Article 61.2 of the Bankruptcy Law. On the basis of the studied arbitration practice, the authors analyze the mistakes made when invalidating suspicious transactions made by legal entities.
Отдельные вопросы развития административного контроля в налоговой сфере.
Authors: Лобачев А.А. , Николаева Т.А. , Прокошин М.С. , Пономарев А.В.
Published: December 2024

В статье представлена ретроспектива появления и развития административного контроля в налоговой сфере. Авторы предлагают историческую периодизацию становления налоговой системы и развития налогового контроля в России, начиная с X века и по настоящее время. Отмечается роль налогового контроля в развитии экономики в разные исторические периоды. В результате исследования формулируются авторские определения понятий «управление налоговыми органами» и «налоговое администрирование».

The article presents a retrospective of the emergence and development of administrative control in the tax sphere. The authors propose a historical periodization of the formation of the tax system and the development of tax control in Russia from the 10th century to the present. The role of tax control in the development of the economy in different historical periods is noted. As a result of the study, the author's definitions of the concepts "management of tax authorities" and "tax administration" are formulated.
Тенденции развития правовой базы в области искусственного интеллекта в России
Authors: Григорьева Н.В.
Published: December 2024

В статье научному анализу подвергнуты базовые нормативные правовые акты, регулирующие общественные отношения в сфере искусственного интеллекта. Рассматривается эффективность принятых актов; выявлены риски и барьеры использования интеллектуальных технологий; определяется дальнейший вектор развития правовых основ в области искусственного интеллекта. Резюмируется, что разработка и принятие закона для урегулирования нового типа общественных отношений, в которых будет участвовать технологический элемент в виде искусственного интеллекта, представляет собой первостепенную задачу. Предложены комплексные меры устранения административно-правовых барьеров развития искусственного интеллекта.

n the article, the basic normative legal acts regulating public relations in the field of artificial intelligence are subjected to scientific analysis. The effectiveness of the adopted acts is considered; identified risks and barriers to the use of intellectual technologies; the further vector of development of the legal framework in the field of artificial intelligence is determined. It is summarized that the development and adoption of a law to regulate a new type of social relations in which a technological element in the form of artificial intelligence will participate is a paramount task. Comprehensive measures are proposed to eliminate administrative and legal barriers to the development of artificial intelligence.
Роль и значение диспозитивности и императивности в регулировании общественных отношений: дискуссионные вопросы
Authors: Прохорко Т.Н.
Published: December 2024

В статье комментируется ряд тезисов, выдвинутых авторами в ходе дискуссии о развитии элементов системы российского права. В основу исследования положено представление о диспозитивности и императивности в регулировании общественных отношений. Отмечается, что восприятие диспозитивности как универсального всепроникающего начала поможет объединить все «основные» элементы гражданского права как отрасли и прекратить дискуссию о том, какой из элементов является для нее более важным, или первичным, определяющим ее уникальность. Каждый из элементов выполняет свою уникальную миссию в развитии гражданского права как мегарегулятора имущественных отношений. Уделяется внимание диспозитивности как идейной составляющей гражданско-правовой отрасли, являющейся одновременно и частью всех ее конституирующих элементов – предмета, метода и принципов.

The article comments on a number of theses, put forward by the authors in the course of discussion of the development of elements of the system of Russian law. The research is based on the concept of dispositiveness and imperativeness in the regulation of social relations. It is noted that the perception of dispositiveness as a universal all-pervading principle will help unite all the "basic" elements of civil law as a branch and stop the discussion about which of the elements is more important for it, or primary, or determining its uniqueness. Each of the elements fulfills its unique mission in the development of civil law as a mega-regulator of property relations. The attention is given to dispositiveness as an ideological component of civil law branch which is at the same time a part of all its constitutive elements - the subject, method and principles.
Clinical picture and diagnosis of uveitis in cat
Authors: Ionaşcu Iuliana
Published: December 2024

Uveitis is one of the most frequent ophthalmic disorders in domestic cats, with diverse etiology that determines blindness. Traumatic uveitis produced by cat claw is unilateral. In systemic diseases, the uveitis are bilateral. Pain is the most important sign, and the clinical diagnosis is easy, while etiological diagnosis remains a challenge.
Untangling Sources of Error in the Density-Functional Many-Body Expansion
Authors: Broderick Dustin , Herbert John
Published: December 2024

Development of meta-generalized gradient approximations (meta-GGAs) has generally led to more accurate density-functional approximations, albeit ones that have more stringent requirements for the quadrature grids that are used to evaluate the exchange-correlation energy. Here, we demonstrate that grid-induced errors are amplified when meta-GGAs are used in conjunction with a many-body expansion, which is a popular means to parameterize classical force fields using electronic structure calculations. At the same time, delocalization errors are exacerbated by the many-body expansion, leading to exaggerated estimates of nonadditive n-body interactions, as illustrated here for anion–water clusters using the meta-GGA functionals SCAN and wB97X-V. Standard grids that are typically accurate for noncovalent interactions with meta-GGA functionals result in runaway error accumulation when used with the many-body expansion. Denser grids eliminate this problem and expose the inherent self-interaction error, which must be mitigated using other strategies that are discussed herein.
Semi-artificial leaf interfacing organic semiconductors and enzymes for solar fuel synthesis
Authors: Yeung Celine Wing See , Liu Yongpeng , Cobb Samuel , Andrei Virgil , Coito Ana , Manuel Rita , Pereira Inês , Reisner Erwin
Published: December 2024

Photoelectrochemical biohybrids combine the advantages of light harvesting semiconductors and biocatalysts into a single compact device. However, limited device stability, the use of toxic elements and non-innocent external components (buffers, mediators or sacrificial reagents) makes a sustainable artificial photosynthetic reaction, where fuel production is coupled to water oxidation, difficult to achieve. Here, we introduce organic photoelectrodes connected to an inverse opal TiO2 matrix that hosts efficient hydrogenase or formate dehydrogenase, driving direct solar fuel synthesis. By co-immobilising carbonic anhydrase, supported by simulations and spectroscopic investigations, the PCE10:EH-IDTBR photobiocathodes generate unprecedented photocurrent densities of up to −8 mA cm−2 in a pH neutral bicarbonate solution, attaining stable H2 production or selective CO2-to-formate conversion over 10 h. Semi-artificial photosynthesis is achieved by assembling the photobiocathode with a BiVO4 photoanode in an artificial leaf device for unassisted CO2 reduction coupled to O2 evolution, attaining a faradaic yield of 87% over 24 h of operation.
Data accessibility in the chemical sciences: an analysis of recent practice in organic chemistry journals
Authors: Bloodworth Sally , Willoughby Cerys , Coles Simon J
Published: December 2024

The discoverability and reusability of data is critical for machine learning to drive new discovery in the chemical sciences, and the ‘FAIR Guiding Principles for scientific data management and stewardship’ provide a measurable set of guidelines that can be used to ensure the accessibility of reusable data. We investigate the data practice of researchers publishing in specialist organic chemistry journals, by analysing the outputs of 240 randomly selected research papers from 12 top-ranked journals published in early 2023. We investigate compliance with recommended (but not compulsory) data policies, assess the accessibility and reusability of data, and if the existence of specific recommendations for publishing NMR data by some journals supports author compliance. We find that, although authors meet mandated requirements, there is very limited compliance with data sharing policies that are only recommended by journals. Overall, there is little evidence to suggest that authors’ publishing practice meets FAIR data guidance.
Real-Time Optical Control of CB1 Receptor Signaling In Vitro with Tethered Photoswitchable THC Derivatives
Authors: Garza Sarahi , Kicin Bilal , Sarott Roman , Pfaff Patrick , Kosar Miroslav , Weishaar Tatum , Schnacke Paul , Lobingier Braden , Carreira Erick , Frank James
Published: December 2024

Understanding the intricacies of the endocannabinoid system is hindered by the lack of tools to target specific pools of CB1 receptors (CB1Rs) across diverse neural circuits associated with mood, motor function, cognition, and other physiological processes. Herein we introduce the first photoswitchable, orthogonal remotely tethered cannabinoid ligand, PORTL-THC24, designed to achieve cell-specific and reversible control of CB1R signaling with high spatial and temporal resolution, thereby overcoming the limitations of conventional freely diffusible ligands. PORTL-THC24 was selectively tethered to membrane-anchored SNAP-tags expressed in live cells, providing reversible optical control of CB1R signaling when photoswitched by UV-A irradiation. We validated the functionality of PORTL-THC24 in live Neuro-2a cells using a novel real-time cAMP imaging assay, demonstrating light-dependent and reversible modulation of endogenously expressed CB1R activity. Additionally, we demonstrate that SNAP-tethered PORTL-THC24 does not induce CB1R internalization, distinguishing it from conventional, freely diffusible agonists. Our results establish PORTL-THC24 as a powerful tool for optical control of CB1R in a spatially-restricted manner, setting the stage for dissecting CB1R function in complex settings and advancing the study of cannabinoid signaling across various physiological and pathological contexts.
Synthesis and Coordination Chemistry of an Integrated Binucleating Ligand Based on Bidentate NacNac and NCN Pincer Frameworks
Authors: Chang Chia Yun , Sgro Michael , Piers Warren , Zhou Wen
Published: December 2024

A new binucleating “Janus” ligand based on the betadiketiminato (“NacNac”) donor combined with an NCN pincer ligand framework has been designed and synthesized. By incorporating pyridyl donors on the imino carbons of the NacNac ligand, two binding sites for metals are introduced. The ligand’s binucleating capabilities are demonstrated by ligating BF2 in the NacNac pocket and NiBr into the NCN pincer bay. The resulting binuclear boron-nickel complexes chemistry was explored by substitution of the bromide ligand on nickel and one fluoride ion on boron with the weakly coordinating triflimide anion [N(SO2CF3)2]- (NTf2). The bromide is replaced preferentially with AgNTf2 and further treatment with Me3SiNTf2 produces a borenium ion by abstracting F- from the BF2 unit. Semiquantitative assessment of the Lewis acidity at the nickel center using the Gutmann-Beckett method shows a substantial increase in Lewis acidity upon conversion of the BF2 to the [BF]+ borenium moiety.
Emergence of the Robeson bound in non-equilibrium molecular dynamics simulations
Authors: Yuan Tianmu , Giro Ronaldo , Steiner Mathias B. , Hsu Hsianghan , Sarkisov Lev
Published: December 2024

Theoretical understanding of multicomponent transport processes in polymer membranes at the molecular level remains a significant scientific challenge due to the high computational cost and poor reproducibility of non-equilibrium molecular simulation methods, aiming at replicating experimental conditions and gradient-driven processes. In this study, we employ Dual Control Volume Molecular Dynamics (DCVMD) with fully atomistic, microsecond-scale simulations to elucidate gas separation mechanisms in porous polymer membranes. Using PIM-PI-8 as a case study, we develop a comprehensive workflow that includes sensitivity analysis and calculations of key transport and structural characteristics of the model membranes. This approach allows us to thoroughly characterize the uncertainties inherent in non-equilibrium simulations and explore the challenges associated with making quantitative predictions using this method. Expanding our analysis to a family of PIM polymers, our simulations successfully replicate several experimentally observed trends. These include a linear correlation between permeability and fractional free volume, as well as the relationship between perm-selectivity and sorption selectivity. Most importantly, we demonstrate that trade-offs between perm-selectivity and permeability emerge in non-equilibrium molecular simulations, qualitatively capturing one of the key patterns in experiments, known as the Robeson upper bound.
Special Care Dentistry: A Challenge to the Profession
Authors: Uppal Simran , Sultan Amina , Kumar Gaurav
Published: December 2024

Special healthcare needs (SHCN) can be developmental, congenital or acquired through trauma, disease or environmental causes, which may limit activities related to daily self-maintenance. Approximately 1 billion people (15% of the population globally) have some disability or special need. Among the dental diseases, dental caries is the most common issue across various disability groups, having a prevalence rate between 27.55% to 91.90% globally, along with poor periodontal health (23.9% - 97%) and Traumatic dental injuries (12.1%-40%). Due to challenges of limited access, financial constraints, lack of trained dental professionals and insufficient awareness about oral health, children's dental problems go undetected, causing a substantial unmet demand for dental treatment later in adulthood. By increasing access to appropriate healthcare facilities, providing dentists with specialized training, and continually implementing new treatment methods, special children can be empowered to receive the dental care they deserve.
Determining the Views of Service Responsible Nurses on Postgraduate Education: A Qualitative Study
Authors: Kara Bircan , Şentürk Sibel
Published: December 2024

Objective: The increasing population and changing demographic structure, scientific advancements, and the growing expectations and need for healthcare specialists are enhancing the importance of higher education in the nursing profession. Understanding the perspectives of service-responsible nurses on postgraduate education is crucial for improving healthcare outcomes. This study aims to determine the views of service-responsible nurses on postgraduate education.
Materials and Methods: The research was designed as a phenomenological qualitative study and was conducted with 13 service charge nurses. Data were collected through in-depth individual interviews using a semi-structured interview form and were analyzed using Colaizzi's seven-stage analysis.
Results: Four main themes with eight categories were identified as follows: (i) "necessity of postgraduate education," (ii) "effects of postgraduate education," (iii) "contributions of postgraduate education," and (iv) "barriers to continuing postgraduate education." It was found that service-responsible nurses generally consider postgraduate education necessary, believe that it enhances professionalism and specialization among nurses, increases professional respect, accelerates the integration of practice and academia, and provides quality patient care.
Conclusions: As a result, responsible nurses see not receiving support from senior management as an obstacle during their postgraduate education process. Based on these findings, it is recommended that upper management support nurses who wish to pursue postgraduate education, that responsible nurses collaborate with universities to facilitate postgraduate education and adopt encouraging policies, and that postgraduate education programs in nursing be integrated with clinical practice.
Mecanismos diferenciados de adquisición
Authors: Peña Sánchez Erick
Published: December 2024

El tema de las tecnologías innovadoras, ya sea un producto farmacéutico o un dispositivo médico, es ofrecer un beneficio adicional a lo que ya existe. Si hablamos de un medicamento, una tecnología innovadora para patologías como el cáncer debe demostrar no solo seguridad, partiendo del principio de "primero no hacer daño", sino que también debe mostrar un beneficio adicional en desenlaces clínicamente relevantes. Esto significa que el beneficio debe traducirse en un efecto sobre desenlaces duros, como la supervivencia global. Aquí vamos a ver algunos detalles sobre lo que se denomina desenlaces sustitutos y la importancia de ser minucioso en el análisis cuando se evalúan tecnologías basadas en estudios pivotales que tienen como desenlaces o "outcomes" estos desenlaces sustitutos.
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Es esencial contar con un marco legal claramente definido, lo que implica un trabajo multisectorial, incluso con el legislativo. Para concluir, las recomendaciones son que los costos derivados de la implementación de estos acuerdos pueden superar los beneficios. Por lo tanto, es esencial limitar su utilización a determinadas tecnologías, lo que implica un análisis específico.
Experiencia comparada con Chile
Authors: Martones Andrea
Published: December 2024

¿Cómo abordamos el desafío del cáncer en nuestros países? Las personas con cáncer son mucho más que su enfermedad; tienen otras comorbilidades que deben ser atendidas. A menudo decimos que nuestros modelos están centrados en las personas, pero ¿realmente es así? ¿O son las personas las que se adaptan a los modelos que proponemos?
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La salud es un gran ecosistema, y no podemos regular solo un aspecto sin afectar al resto. La regulación es mucho más amplia de lo que les he contado. Solo quería compartir cómo hemos avanzado en este largo camino. La Ley Nacional del Cáncer lleva dos años, pero en realidad, llevamos más de 15 años trabajando en la implementación de macro redes, y todavía enfrentamos desafíos. Hemos aprendido mucho, y también reconocemos lo que aún nos falta aprender.
Apertura
Authors: Berrospi Espinoza Francisco , Pérez Flores Jorge , Peña Sánchez Erick , Rodríguez Nomura Huber Ezequiel
Published: December 2024

Es un honor para mí estar presente en este primer congreso de políticas públicas de salud y cáncer. Considero que esta es una iniciativa sumamente importante y ambiciosa, de alcance regional y, ¿por qué no?, macrorregional. Su objetivo es abordar y profundizar en temas cruciales como la política de salud y cáncer.
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Este congreso cuenta con extraordinarios ponentes, y agradezco la convocatoria realizada por la doctora Liliana. Es esencial que, más allá de las políticas, se asignen presupuestos adecuados para la implementación, supervisión y obtención de resultados efectivos en la prevención y curación del cáncer. Nuestra casa de estudios, al igual que otras universidades, tiene la responsabilidad de formar profesionales íntegros en el área de la salud, quienes serán la columna vertebral de la implementación de estas políticas.
Factors Associated With Cessation of Exclusive Breastfeeding Among Working Women
Authors: Kalimah Kalimah , Girsang Ermi , Manalu Putranto
Published: December 2024

Exclusive breastfeeding for the first six months are crucial for infant nutrition. The condition of mothers as workers is reported to be one of the factors that hinders exclusive breastfeeding, while the number of working mothers continues to increase every year. This study aimed to evaluate the level of exclusive breastfeeding and identify factors associated with the cessation of exclusive breastfeeding among working mothers. This research employed an analytical observational study. Data was collected from five health center areas in Langkat district, involving 165 working mothers. Samples were taken using a purposive sampling technique. Data analysis included univariate, bivariate (chi-square), and multivariate (logistic regression) analyses. This study reported low levels of exclusive breastfeeding among working mothers. Several factors were associated with breastfeeding, namely age (OR=2.13, 95% CI, 1.07-4.24); p=0.044), education (OR=2.40, 95% CI, 11.24-4.64; p = 0.009), knowledge (OR= 27.08, 95% CI, 10.88-67.37; p<0.001), attitude (OR=18.80, 95% CI,8.33-42.43; p<0.001) and husband's support (OR=8.14, CI 95%, 3.92-16.87; p<0.001). This study concluded that adequate knowledge, a positive attitude towards breastfeeding, and a husband's support are key factors for the success of exclusive breastfeeding for working mothers. Therefore, health workers must pay special attention to these aspects by providing education on the importance of breastfeeding for pregnant women and husbands by providing education of exclusive breastfeeding. It is suggested that future research design a model of public health education to increase the quality and quantity of exclusive breastfeeding among employed women.
Determinant of Neonatal Visit Coverage Rate in Serdang Bedagai Regency North Sumatra Indonesia
Authors: Br Ginting Munthe Novita , Machmud Rizanda , Semiarty Rima , Serudji Joserizal , Bachtiar Adang , Fitry Yani Finny , Symond Denas , Nelwati Nelwati
Published: December 2024

Neonatal mortality is a leading cause of infant deaths, particularly in developing countries. In Serdang Bedagai Regency, the coverage of neonatal visits remains low, contributing to the high neonatal mortality rate and causing economic losses. This study aims to identify factors related to the neonatal visit coverage rate in Serdang Bedagai Regency, North Sumatra, Indonesia. This study used a cross-sectional design with multivariate analysis. Data were collected from 200 mothers with babies aged 0-28 days in five health centers in Serdang Bedagai Regency. The variables analyzed include age, education, economic status, knowledge, maternal attitudes, culture, family support, midwife attitudes, access to health facilities, and service quality. The data were analyzed using logistic regression. The results showed that the variables consistently and significantly affecting the increase in neonatal visit coverage were maternal education, knowledge about neonatal visits, local culture, husband/family support, and the quality of visit services. Factors that significantly contributed to increasing coverage of neonatal visits were maternal education (p-value = 0.004, OR = 14.285), maternal knowledge (p-value = 0.000, OR= 75.920), local culture (p-value = 0.000, OR = 57.105), husband/family support (p-value = 0.000, OR = 77.763), and service quality (p-value = 0.000, OR = 47.474). These factors have a major influence in supporting the success of the neonatal visit program, with maternal knowledge and family support being the most dominant factors.. Efforts to increase coverage should involve educating mothers, involving families, and enhancing services while considering local wisdom.
Radiografía a la informalidad urbana en el centro histórico de la ciudad de Ibarra
Authors: Díaz Quintana Patricio , Briceño Ávila Morella
Published: December 2024

La ciudad de Ibarra, fundada en el siglo XVII como un punto de tránsito entre Quito (Ecuador) y Pasto (Colombia), se ha caracterizado históricamente por su ubicación estratégica. Originalmente como una encrucijada, ha sido escenario de importantes flujos migratorios y de actividades socioeconómicas que han evolucionado en su territorio. A lo largo del tiempo la ciudad ha desarrollado dinámicas sociales complejas, marcadas por la interacción de actores locales y externos.
 
Este estudio examina los procesos de movilidad irregular en el centro histórico de Ibarra tras la pandemia, con el objeto de analizar la percepción de los residentes de la ciudad y los patrones de ocupación del espacio público. Los escenarios establecidos dentro de la investigación corresponden a dos variables principales de análisis, el primero engloba la movilidad irregularizada, el segundo refiere a la percepción de informalidad urbana. El modelo de investigación tiene un enfoque teórico basado en los métodos mixtos (cuantitativo – espacial) y se sustenta con datos oficiales, la georreferenciación del espacio público y una encuesta de percepción ciudadana con el fin de comprender cómo los distintos actores sociales experimentan el espacio ante los fenómenos de informalidad urbana. Los resultados muestran que lo flujos migratorios han aumentado los niveles de degradación del espacio público, la inseguridad urbana y la estigmatización social. Si bien los problemas de inseguridad urbana, estigmatización y la creación de fronteras naturales aún no son visibles para la ciudadanía, la percepción de estos fenómenos ha comenzado a generar impactos significativos tanto en la población, como en la segregación y la estratificación de la estructura social. Este modelo teórico – espacial deja un campo abierto para que futuros investigadores identifiquen nuevos fenómenos urbanos donde el espacio público sea un elemento positivo del desarrollo social.
A NOVEL MACHINE LEARNING APPROACH TO CALORIE ESTIMATION FOR DIABETES AND OBESITY MANAGEMENT
Authors: Venkata Ravi Kiran Kolla
Published: December 2024

In an era where dietary choices significantly impact health and wellness, the accurate assessment of calorie intake is of paramount importance. "DeepCalorie" presents an innovative food calorie detection device that leverages state-of-the-art machine learning techniques. This device aims to empower individuals with the ability to effortlessly estimate the calorie content of their meals by simply capturing images. The system utilizes a diverse dataset of food images, deep neural networks for feature extraction, and sophisticated algorithms to estimate calorie counts. Furthermore, it offers the option to assess portion sizes, providing a more comprehensive dietary analysis. With its user-friendly interface, the "DeepCalorie" device represents a promising step towards promoting healthier eating habits and fostering nutrition awareness. This paper details the development process, challenges encountered, and the potential impact of this technology on improving dietary choices and overall well-being.
Diaspora Turizmi: Almanya daki Üçüncü Kuşak Türklerin Seyahat Motivasyonları ve Anavatana Bağlılıkları Üzerine Bir İnceleme (Diaspora Tourism: A Study on Travel Motivations and Loyalty to the Homeland of Third Generation Turks in Germany)
Authors: Güzeloğlu Ferdi Tayfur , Ayaz Dönmez Nermin
Published: December 2024

Bu araştırma, Türkiye’ye seyahat eden Almanya’daki Türk diasporası üçüncü kuşak bireylerin Türkiye’ye seyahat motivasyonları ve anavatan bağlılığını incelemek amacıyla gerçekleştirilmiştir. Dünya genelinde çeşitli diaspora toplulukları mevcuttur. Bu topluluklar farklı göç tarihine, kültürel kimliğe, anavatanları ile ilgili farklı seyahat motivasyonu ile deneyime ve anavatan bağlılığına sahiptir. Anavatanı ziyaret sonrasında olumlu, olumsuz ve tarafsız düşünceler gelişmekte ve bu durum kuşaktan kuşağa farklılık göstermekte ve araştırmalara konu olmaktadır.Bu çalışmada veri toplama amacıyla Almanya’nın Kuzey Ren Vestfalya Eyaletinde ikamet eden 25 Türk katılımcıyla yarı yapılandırılmış yüz yüze görüşme gerçekleştirilmiştir. Elde edilen veriler içerik analizi ile değerlendirilmiştir. Katılımcılar, Türkiye'yi ziyaret etmeyi genellikle aile ve arkadaşları ile gerçekleştirirken, seyahat motivasyonları Türkiye'nin turistik yerlerini görmek, Türk mutfağının tadını çıkarmak, kültürel ve tarihi bilgi edinmek, akraba ve arkadaş ziyaretleri, ailevi yükümlülükleri yerine getirmek ve çeşitli etkinliklere katılma şeklindedir. Katılımcılar Türkiye’ye seyahat ederek hem kendilerinin hem de çocuklarının ulusal kimlikleri olan Türk kimliğini koruma ve sürdürme, Türk kültürünü yerinde tanıma, dili daha iyi öğrenme yoluyla anavatanla bağlarını güçlendirmektedir. Almanya’da doğmuş ve yetişmiş olsalar dahi katılımcılar diaspora turizmi ile ulusal kültür, aidiyet, kimlik aktarımını zenginleştirmektedir.