bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Orang Tua dalam Meningkatkan Kemandirian Anak Tunagrahita di SLB Untung Tuah Samarinda
Authors: Anisa Anisa , Wijaya Ida Suryani , Ridho Miftahur , Zahra Zahra
Published: February 2024

Disabilitas tunagrahita merujuk pada sebuah kondisi dimana individu memiliki kemampuan intelektual di bawah rata-rata. Anak dengan disabilitas tunagrahita memiliki hambatan terkait perkembangan mental dan intelektual yang berdampak pada perkembangan kognitif dan perilaku adaptif. Penyandang disabilitas tunagrahita memerlukan perlakuan yang khusus agar kemampuannya bisa berkembang secara maksimal, sehingga dalam hal ini diperlukan peran orang tua dalam membentuk kemandirian anak tunagrahita pada berbagai konteks yaitu rumah, sekolah dan lingkungan sosial anak. Penelitian ini bertujuan untuk mengetahui bagaimana strategi orang tua dalam meningkatkan kemandirian anak tunagrahita di SLB Untung Tuah Samarinda. Penelitian ini merupakan penelitian yang menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Subjek dalam penelitian ini adalah 5 orang tua dengan kriteria memiliki anak tunagrahita yang bersekolah di SLB Untung Tuah Samarinda. Teknik sampling yang digunakan adalah accidental sampling. Teknik pengumpulan data dalam penelitian ini berupa observasi dan wawancara, serta instrumen yang digunakan adalah pedoman observasi pedoman wawancara. Teknik analisis data Miles dan Huberman yang digunakan dalam penelitian ini mencakup pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa orang tua dengan anak tunagrahita di SLB Untung Tuah Samarinda menggunakan strategi tanpa paksaan serta melatih anak secara bertahap, perlahan, sabar dan menyerahkan semuanya kepada Tuhan. Orang tua juga bekerja sama dengan guru saat di sekolah serta mendapatkan bantuan dari keluarga untuk meningkatkan kemandirian anak di lingkungan rumah dan sosial. Faktor pendukung bagi orang tua yaitu keluarga, sementara faktor penghambat orang tua mencakup perundungan terhadap anak, penyakit lain yang diderita anak, dan lain sebagainya.
Development Strategy of Msme Through Zakat, Infak, Sedakah to Realize Economic Empowerment
Authors: Safriyanto Safriyanto , Rosyidah Faridatur , Adawiyah Robiatul
Published: February 2024

This study aims to determine the potential of ZIS funds in developing MSMEs and the mechanisms carried out in empowering MSMEs through ZIS funds so that they can realize a better economy. Micro, Small and Medium Enterprises (MSMEs) are business actors who have a strategic role in economic development efforts. national. However, the potential possessed by micro-enterprises still has various obstacles both in increasing market share and in terms of capital. These obstacles can be minimized by utilizing Zakat, Infak, Alms (ZIS) funds in the form of financing assistance along with productive empowerment so that they can have an impact on the development of micro-enterprises. The method in this research is conceptual research using secondary data through a qualitative descriptive approach. The results showed that the mechanism for developing MSMEs through ZIS funds, apart from providing capital or financing, was followed by a sustainable empowerment model in the form of monitoring, coaching, and training. Another impact obtained from optimizing ZIS funds is creating economic independence and increasing the selling value of business products both in terms of licensing and halal certification.
Entrepreneurship Learning by Experiential Learning in Motivating Student Courage to Start an Enterprise
Authors: Asy’ari Qaiyim , Dwiaryanti Risca , Kunaifi Aang
Published: February 2024

Entrepreneurship is the key to the progress and prosperity of a nation. Apart from being a driver of economic activity and the distribution of wealth, entrepreneurship is also an indicator to measure the progress of a country. Developed countries on average have a composition of 15-20% entrepreneurs of the entire population. In fact, Indonesia still has around 4% of entrepreneurs. Therefore, a comprehensive strategy is needed to create new entrepreneurs, one of which is by intensifying entrepreneurship learning in schools and universities. This paper aims to formulate and describe effective entrepreneurship learning through experiential learning methods.Through qualitative research methods with an case study approach, the research is compiled into a paper presented at an international conference on Islamic economy and law. Data were collected through primary sources, from interviews with students before and after implementing the experiential learning formula for one semester at a private university. From these findings, concepts and methods for implementing experiential learning in entrepreneurship learning are compiled. The results of this study indicate that to move students to dare to enter the world of entrepreneurship, strong motivation and applicable training are needed. Motivation and training directly in the field turned out to be able to raise the courage of students in greater numbers to engage  in entrepreneurship. With the results of this study, it is hoped that entrepreneurship learning in schools and universities in particular will become more systematic and effective.
Optimization of Waqf Through Islamic Boarding Schools in The Madura Region in Overcoming Climate Change and Economic Empowerment ff The Plantation Sector
Authors: Pramita Putri , Nisa Mir'atun , Maulana Asep
Published: February 2024

This Paper tries to elaborate the Potential and Role of Waqf as one of Islamic Social Fund in helping to deal with climate change problems that occur on earth. This research is conceptual with a qualitative approach, referring to the previous literature related to related topics. The results of this study are the concept or model of optimizing waqf, especially waqf through money and land waqf in dealing with the phenomenon of climate change and supporting a pesantren-based economy in the Madura area. Land waqf by wakif will become the object of model development, while waqf through money will be managed to buy assets in the form of plant seeds that are proven to be able to overcome climate change. The theoretical contribution of this research is expected to be able to add and complete literacy and research related to waqf management models in supporting the SDGs and social aspects of society. Meanwhile, practically, the waqf management model for climate management can be a policy recommendation for the Madurese community and local government to be carried out in the future.
The Emergence of Online Halal Food Delivery Services in Brunei Darussalam Amidst Covid-19
Authors: Sulaiman Nor Surilawana , Hashim Norkhairiah , Abdullah Rose
Published: February 2024

The COVID-19 outbreak was detected in Wuhan, China before spreading throughout the world. Lockdowns, movement restrictions, social distancing, suspension of public gatherings at a certain number, and other measures have been implemented by governments and world leaders to lessen the loss of life and health. Despite being necessary, these measures have caused a massive economic crisis that has wreaked havoc on businesses and industries, including the halal industry. Due to restrictions, restaurants, for instance, are not permitted to offer dine-in service. Spite of the difficulties, the COVID-19 outbreak has prompted numerous restaurants to seek alternate solutions and develop innovative in-house Online Food Delivery (OFD) services, while others have established third-party OFD service providers and individuals have become runners.The purpose of this study is to look into the emergence of OFD services in delivering halal foodacross Brunei Darussalam during COVID-19 outbreak. The researchers refer to relevant publications in this area to discuss the online halal food delivery during COVID-19. As a result, for some businesses, COVID-19 is a hidden blessing because it enables them to innovate their operations
HALAL PRODUCT TRACEABILITY SYSTEM MODELING USING INTERPRETIVE STRUCTURAL MODELING (ISM) IN BANGKALAN HALAL INDUSTRIAL AREA
Authors: Prastiti Novi , Rahmawati Diana , Julanto Endharta Alfonsus , Deanova Alunanika Tasya
Published: February 2024

Requirements for listing halal products are regulated in the Undang-undang Jaminan Produk Halal No. 33 of 2014. Fraud in the form of counterfeiting products labeled halal starts from not opening the entire halal production process from upstream to downstream of the supply chain. Therefore, to maintain product halalness, it is necessary to apply the traceability of halal products in the food supply chain as an effective tool to ensure product halalness and ensure food safety. The main objective of a traceability system is to record and document the product including all materials used in the production process. The method used to model the traceability system of Halal supply chain products is the Interpretive Structural Modeling (ISM) approach. Elements of the Halal Supply Chain Traceability System include Halal Procurement, Halal Manufacturing, Halal Logistics, Halal Distribution, Supplier Traceability, Manufacturer Traceability, Logistics Traceability and Distribution Traceability. Halal Product Traceability System Modeling aims to accelerate the development of the Bangkalan Halal Industrial Estate. Modeling of the Supply Chain halal traceability system in maintaining the integrity of halal products in the Bangkalan halal industrial area is located in the Power Driver Quadrant, namely Logistic Traceability, Distribution Traceability, Producer traceability, and supplier traceability. Quadran Strong Driver-Strongly Dependent Variable (Linkage), consisting of halal distribution and halal manufacturing elements. Quadran II Driver Power, namely halal logistics and halal procurement. And there are no elements in Quadran I. It can be concluded, the Bangkalan halal industrial area requires all elements to be related. So as not to make tourists visiting Bangkalan worry about the halal guarantee system for Bangkalan regional products.
OVERVIEW OF HALAL FOOD SMEs: A BIBLIOMETRIC ANALYSIS
Authors: Izzah Nurul , Hayati Lubis Rini , Karima Sovia Annida
Published: February 2024

The increasing demand for halal food encourages the need to increase the potential of halal food SMEs in the global halal industry competition. This paper aims to reduce research articles related to halal food SMEs. The data used are articles from the Scopus database for 2014-2023. Data were analyzed using bibliometrics with the VOSviewer application displayed in graphical form. The results of the study show that in the last 10 years, researchers have received positive attention to the study of halal food SMEs. Based on the co-authorship criteria, three groups of writers were obtained. While the co-occurrence criteria used 69 keywords, nine clusters were obtained. The nine clusters are halal food, halal food industry, SMEs, food, logistics, halal, business, performance and halal food certification.
INSTITUTIONAL RESILIENCE IN BUILDING HALAL HUMAN CAPITAL IN DIMADURA USING THE INSTITUTIONAL DEVELOPMENT FRAMEWORK (IDF) METHOD
Authors: Putri Rahayu Alfina , Dzikrulloh Dzikrulloh , Chuk's Mayvani Titov
Published: February 2024

One of the main problems in halal development is the quality of human resources. Several approaches to improvingthe quality of human resources in organizations are human capital. Therefore, the aim of this research is tomeasure the resilience of institutions in human resource improvement programs. This research method is descriptivequalitative with an Institutional Development Framework approach. The object of this research is an institutionthat focuses on halal development in Indonesia. The object of this research is limited to the Ministry of Religionand the MES Organization (sharia economic community). The data used are primary and secondary data. Datacollection techniques use interviews, questionnaires by filling in the IDF matrix, IDF Index, priority target chartsand documentation. The results of this research found institutional resilience index values for institutional andmanagement resources, human resources, external institutional resources, financial resources and human capitaldevelopment program indicators. These results describe comprehensive organizational tools in terms ofmanagement, human resources, leadership, finance and human capital development programs. The implicationsof this research are useful for related institutions in developing programs and policies in developing halal humanresources in the future, because the output of this research is an index of institutional resilience which can be usedas a basis for evaluating human capital development programs.Keywords: Institutional Resilience, Human Capital, Institutional Development Framework, IDF
THE ROLE OF BAZNAS SUMENEP IN SUPPORTING HALAL PRODUCT CERTIFICATION IN MICRO, SMALL AND MEDIUM ENTERPRISES IN LENTENG MARKET THROUGH THE DISTRIBUTION OF ZAKAT, INFAQ AND SADAQAH
Authors: Iqbal Yusfardian Moh. , Choiri Muttaqin
Published: February 2024

Various things related to Halal Product Certification, which apparently is still difficult toimplement in the context of Micro, Small and Medium Enterprises assisted by Baznas Sumenep, namelyat Lenteng Market, Sumenep Regency. This is because Micro, Small and Medium business actors areinconsistent with their business and business actors have difficulties with capital. This research aims :First, to determine the role of Baznas Sumenep in Supporting Halal Product Certification for Micro,Small and Medium Enterprises in Lenteng Market. The second obstacle is Baznas Sumenep insupporting Halal Product Certification for the Micro, Small and Medium Enterprises it supports,namely at Lenteng Market through the distribution of Zakat, Infaq and Sadaqah funds. The type ofresearch used is descriptive qualitative with data sources obtained through observation, interviews anddocumentation. The results obtained from this research say that with the existence of Halal ProductCertification for Micro, Small and Medium Enterprises, Baznas Sumenep strongly agrees with theexistence of Halal Certification. Apart from that, Baznas Sumenep itself has not focused on HalalCertification because Baznas itself does not have significant authority where Baznas only focuses oncapital assistance to Micro, Small and Medium Enterprises in Lenteng Market. Baznas Sumenep itselfhas five work programs incluiding, Sumenep Peduli, Sumenep Taqwa, Sumenep Smart, SumenepHealthy and Sumenep Prosperous. Which in the Sumenep Makmur program is tasked withcoordinating the distribution of Zakat, Infaq and sadaqah to mustahik in the form of empowerment orutilization . in empowerment or utilization, namely those related to working capital assistance, workequipment assistance and capital assistance for Micro, Small and Medium Enterprises in LentengMarket.Keywords : Halal Certification, Micro,Small and Medium bussiness, Zakat, Infaq,sadaqah Funds
THE EFFORTS OF THE INDEPENDENCE OF MTA PESANTREN PUTRI AL-AMIEN IN DEVELOPING THE HALAL ECOSYSTEM IN THE ECONOMIC FIELD FROM THE PERSPECTIVE OF PP NO. 39 OF 2021 CONCERNING PBJPH
Authors: Ikasati Nur , Nahidloh Shofiyun
Published: February 2024

In the development of the Muslim population, which is currently expanding, it can cause or have a majoreffect on the economy in the surrounding community, including the Muslim population in Indonesia,which has an influence on the development of the halal ecosystem which has a great opportunity for theeconomy in Indonesia and in the world. Islamic boarding school educational institution which is one ofthe educational institutions engaged in teaching Islam, which exists in the midst of society. It has economicindependence that is well developed and managed through the economic system built by the boardingschool. And this shows that there is an economic and financial system that is managed through a shariafinancial system, so this is a reinforcement for the development of halal ecosystems in Islamic boardingschools. This study aims to determine how the independence efforts that have been instilled in the MTAPesantren Putri Al-Amien in the development of the halal ecosystem in the economic field from theperspective of PP No. 39 of 2021 concerning PBJPH. This type of research uses descriptive qualitativeresearch methods which are considered very appropriate in developing the potential for the halal ecosystemin the economic field owned by the MTA Pesantren Putri Al-Amien The results obtained in this studystate that the MTA Pesantren Putri Al-Amien already has independence in developing the halalecosystem in the economic field of the types of business units that exist in the Islamic Boarding Schoolenvironment, so that the Islamic Boarding School has the means in guidance to develop its independence.Keywords: Self-Reliance Efforts, Islamic Boarding School, Halal Ecosystem
MOBILE APPLICATION FOR HALAL FOOD PRODUCT INFORMATION WITH GEOFENCING TECHNOLOGY BASED ON QR CODE
Authors: Rahmawati Diana , Neipa Purnamasari Dian , Sofiana Risa , Setiawan Heri , Alfita Riza , Vivin Nahari Rosida
Published: February 2024

Industry 4.0 technology in the food sector aims to increase productivity more efficientlyand better quality to improve competitiveness. People are increasingly aware to alwaysseek information and use food products that will be consumed. Consumers really needaccurate information about the status of a food product easily and instantly. Design andimplement a mobile application that aims to improve consumer’s informationaccessibility about food products. This application also allow users to share informationabout food products using android-based mobile devices. The system is designed usedto get practical and easy solutions in verifying halal food products using QR(QuickResponse) codes and geofencing technology. This system will be tested using SIT(System integration testing) which is a process used to check the speed, stability,scalability and use of software resources. This application, it is expected to make it easierfor each user to know the halalness of food products as well as other information inorder to consume these products. Geofencing technology also makes it easier for usersto know the locations that provide the same product. Based on geofencing testing, thelow MSE value (0.51) owned by WiFi network, 3G network has a much greater value(12.13).Keywords : Geofencing, Halal Products, Mobile Application, QR Code, SystemIntegration Testing
PROBLEM AND BENEFITS OF HALAL CERTIFICATION FOR MICRO, SMALL AND MEDIUM ENTERPRISES (MSMEs) IN BANGKALAN REGENCY IN REVIEW OF LAW NO.33 OF 2014
Authors: Surya Vanny Savita
Published: February 2024

Based on data from the Central Bureau of Statistics in 2022, Indonesia is a country with apopulation of 275,773.8 million with a Muslim population of around 237.56 million. Thus,Indonesia has a huge opportunity to become a halal food producer. The halal industry is one ofthe topics that is currently widely discussed in the international business environment.Bangkalan Regency is one of the areas with the largest number of MSMEs in Madura, which isaround 22,500 MSMEs. There are 196 MSMEs in Bangkalan Regency that have been halalcertified, this is evidenced by data obtained from the UTM halal center. However, ironically,almost all MSMEs in the Regency do not have halal certification. This is evidenced by dataobtained from the Office of Cooperatives and Micro Enterprises and the Office of Industryand Trade of Bangkalan Regency. The diversity of MSMEs in Bangkalan Regency has nowincreased along with the times, therefore the government has issued a regulation stipulating thatall kinds of products circulating in Indonesia are obliged to be halal certified, in accordance withLaw No. 33 of 2014 concerning Halal Product Guarantee. Madura with the potential of a societythat has a strong character to uphold Islamic teachings and economic potential is verysupportive of the development of the business world. However, the facts in people's lives, thebusiness world in Madura has not developed as expected. This is because there is no goodregulation on business in accordance with the characteristics of the people of Madura. One ofthe efforts to realize this is the existence of Halal certification for MSME players. Therefore, itis hoped that this research can provide solutions and benefits to the problems that are currentlyoccurring. This study aims to determine how the problems and benefits of halal certification forMSME players in Bangkalan Regency are viewed from Law No. 33 of 2014. This research isdescriptive qualitative research. Data collection was carried out using interviews, documentationand observation techniques to several MSME actors in Bangkalan Regency.Keywords : Problematics, Benefits, Halal Certification, MSMEs
GIS-integrated multi-criteria suitability anal¬ysis for healthcare facilities site selection in Rajouri district, Jammu and Kashmir, India
Authors: Kheraj Arshad Ahmed , Ali Amjed , Rani Kiran , Meenaxy
Published: February 2024

The study aims to develop a Decision Support model for the selection of a suitable site to establish a new healthcare center with adequate facilities based on the analytical hierarchy process (AHP) in the Rajouri district of Jammu and Kashmir. This study utilized AHP and GIS to identify an appropriate location for a new healthcare center. The study employed eight criteria to evaluate potential locations and utilized pairwise comparison to assign weights to each criterion. GIS-based spatial analysis was used to create factor and suitability maps for each criterion. Suitability was evaluated on a scale of 0 to 10 and each factor map was combined using the ArcGIS weighted overlay selection tool. The final map of the study represents the suitable site for a healthcare center in the Rajouri district and it shows the sites from the highly suitable to the least suitable area. In Rajouri district, mostly the central part can be considered very suitable as the population density of this area is higher compared to other areas of the district. The southwestern parts of the district are moderately suitable or least suitable sites for a new healthcare center. The study displays the pattern of the existing location of healthcare centers, mostly, the existing locations are not proper and suitable. Therefore, in the future, the allocation of healthcare centers must be in more adequate areas. Policymakers and healthcare professionals can be benefitted from this study in selecting suitable locations for future hospitals, which could ultimately improve access to healthcare services in the region. Additionally, the study can be contemplated in developing new policies for better transportation system in the study area.
Quantitative morphometric analysis of streams in extreme humid areas a case study of the Um-Mawiong river basin, Mawsynram, Meghalaya
Authors: Ryntathiang Bring Blessing L , Lyngdoh Andy T.G
Published: February 2024

Quantitative morphometric analysis of the drainage system is essential to characterising a watershed, as all the hydrologic and geomorphic processes occur within the watershed. Consequently, this plays a crucial role in understanding the geo-hydrological attributes of a drainage basin to the terrain feature and its ﬂow patterns, thus enabling the estimate of the incidence of inﬁltration and runoff and other related hydrological characteristics of a watershed, which strongly impacts natural resource conservation. The study area selected is the Um-Mawiong River basin in Mawsynram, Meghalaya. The basin shows a dendritic pattern that highlights the homogeneity in the texture of the basin. Results suggest that the stream frequency of the basin is 19.10 km², suggesting a faster surface runoff and less infiltration. In addition, it has an Elongation ratio of 0.75 indicating an elongated basin shape. The current study demonstrates that the implementations of GIS techniques are trustworthy, efficient, and capable of managing extensive databases for managing river basins. The present study tries to analyse the linear, areal and relief aspects of the basin using a GIS environment and manipulated for different calculations. The analysis reveals that the total number of stream segments and length are maximum in first-order streams and decrease as stream order increases. The drainage density exhibits a high degree of positive correlation, i.e., 0.87, with its frequency suggesting an increase in stream population concerning increasing drainage density and vice versa.
Intervenciones basadas en mindfulness para la prevención de recaídas en el consumo de alcohol: una revisión sistemática
Authors: Bernaldo-de-Quirós Mónica , Amores Alejandro
Published: February 2024

Introducción: las tasas de recaída en el consumo de alcohol se mantienen elevadas durante el seguimiento tras el tra-tamiento con intervenciones psicológicas de eficacia demostrada. Las intervenciones basadas en mindfulness (IBM) pueden ser una alternativa pero es necesario demostrar la eficacia y mecanismos de acción de estas intervenciones. Objetivo: la presente revisión sistemática trata de evaluar la eficacia de las IBM en el consumo de alcohol en pobla-ción adulta. Metodología: se realizó una búsqueda de ensayos clínicos publicados entre los años 2016 y 2021 en las bases de datos PubMed, PsycInfo y Web of Science. El informe de esta revisión se realizó siguiendo las recomendacio-nes de la declaración PRISMA. Resultados: Se encuentran resultados favorables en reducción del deseo de consumo y de la cantidad de bebida, así como mejoras en la gestión del afecto negativo y el estrés. Las IBM pueden fomentar una mayor tolerancia al estrés a través del aprendizaje de técnicas de regulación adaptativas. Conclusión: las IBM y componentes de mindfulness parecen ser útiles para la reducción de factores de riesgo de recaída en el consumo de alcohol, como estrategia combinada con otras intervenciones eficaces. No obstante, la heterogeneidad de resultados y diseños metodológicos no permiten extraer conclusiones definitivas.
Image perception of Guadalajara city by foreign exchange students of the metropolitan area of Guadalajara
Authors: Balla Louise
Published: February 2024

This text discusses the importance of cities and universities in recruiting international students, emphasizing the need to consider this population in city branding efforts. International students’ mobility has increased globally, leading cities like London, Tokyo, Melbourne, and Montreal to adopt active policies to recruit international students. Reasons for recruiting international students vary, including countering aging populations, addressing skill shortages, and improving cultural diversity. Universities benefit financially and culturally from international students and gain knowledge from those coming from prestigious institutions. The text highlights the need to understand what attracts foreign students into a city like Guadalajara for academic exchange programs and the importance of using these elements to create a brand strategy.
40 años de teatro comunitario argentino:
Authors: Hanna Andrea
Published: February 2024

El presente artículo tiene por objetivo caracterizar los principales procesos históricos del teatro comunitario, particularmente en la Ciudad de Buenos Aires, a 40 años de su nacimiento. Para ello, haremos foco en las particularidades de su gestión, producción ejecutiva y públicos con apoyatura en la bibliografía etnográfica que la propia autora puede desarrollar a través de su experiencia profesional. Recorreremos las políticas públicas que contemplan, en específico, la práctica del teatro comunitario argentino, práctica que, desde el ejercicio del derecho a la cultura y al arte que nos asiste como seres humanos, produce transformación social. A partir de casos específicos, destacaremos ejemplos que pongan en valor el trabajo en red como potencia de construcción y contención. Procuraremos acercar, entonces, a algunos conceptos y experiencias que puedan dar luz sobre esta práctica que, siendo altamente transformadora, suele ser poco visibilizada por los diferentes actores, públicos y privados, que recorren los caminos de las artes escénicas.
Interaction between Pipe Rotation and Cuttings Transport in Extended-Reach Drilling: Mechanism, Model, and Applications
Authors: Zhao Jun , Huang Wenjun , Gao Deli
Published: February 2024

High drag and torque on drillstring and difficulty in hole cleaning are two major challenges in extended-reach drilling, and these two challenges are usually coupled with each other. However, previous studies considered the drillstring mechanics and hole cleaning as two relatively independent issues and studied them separately, which cannot fully reveal the complex mechanisms of pipe sticking and obtain proper drilling parameters to ensure hole cleaning and reduce drag and torque. To solve this problem, in this paper we present the concept of pipe-cuttings interaction and elaborate on the two interaction mechanisms, which are the effect of pipe rotation on cuttings transport and the effect of cuttings distribution on pipe load. Second, we introduce the stirring diffusion factor and pipe-cuttings contact stress to quantify the pipe-cuttings interaction, and we obtain their mathematical expressions through nonlinear regression of numerical simulation results. Third, we establish the mechanical pipe-cuttings interaction model by modifying and combining the tubular mechanical model and the cuttings transport model. Finally, we validate the interaction model and apply it to a case study of extended-reach drilling in the South China Sea. The results show that the interaction model is of high prediction accuracy and is superior to the conventional tubular mechanical and cuttings transport models because the interaction between pipe rotation and cuttings transport is sufficiently considered. The problem of poor hole cleaning for a 12¼-in. section is serious, and pipe sticking occurs frequently for the extended-reach well in the case study because the stationary bed height is more than 10% in actual drilling. It is usually difficult to ensure hole cleaning of a 12¼-in. section by only optimizing a single parameter of rate of penetration (ROP), flow rate, or rotational speed, but optimizing two of the parameters at the same time can achieve better results. Lastly, we establish a recommended chart of drilling parameters, which can aid engineers in making comprehensive recommendations on drilling parameters.
Paracetamol (N-acetyl-para-aminophenol) disrupts early human embryogenesis
Authors: Kristensen David , Nielsen Brian , Petersen Morten , Martin-Gonzalez Javier , Holmberg Christian , Mjøseng Heidi , Frederiksen Hanne , Rosenthal Cristal , Jørgensen Emma , Serup Palle , Christensen Sarah , Petersen Kathrine , Kristiansen Karsten , Jørgensen Niklas , Hay-Schmidt Anders , Pedersen Per , Juul Anders , Pinborg Anja , Ziebe Søren , Lindenberg Svend , Elers Jimmi , Lindenberg Frederikke , Zedeler Anne , Christensen Søren
Published: February 2024

It is estimated that 10–40% of all human conceptions fail around implantation1-7. Genetics explain ≈ 50% of early embryonic loss, leaving a substantial part of early loss without a known cause8,9. Smoking and alcohol are known risk factors for spontaneous abortion, indicating the importance of the chemical environment during embryonic development10. Here we show that paracetamol (N-acetyl-para-aminophenol (APAP); otherwise known as acetaminophen), the recommended medication for pregnant people for treatment of mild to moderate pain and fever11 and an environmental pollutant12-15, disrupts both mouse and human pre-implantation development. We found that APAP inhibited cell cycle progression, likely through ribonucleotide reductase, resulted in blockage of DNA synthesis across all model systems, and reduced pregnancy outcomes in mouse models. At concentrations found in the reproductive system of women after standard administration, APAP exposure decreased human cleavage stage embryo cell numbers or caused direct embryonic fatality. Similar exposure to human blastocyst stage embryos for 6 h resulted in decreased DNA synthesis as well as morphological changes. Our data demonstrate that a widely used mild analgesic and environmental pollutant might result in embryonic loss and provide a foundation for understanding environmentally caused cell cycle inhibition in other processes during development.
Preliminary Field Validity of Free-Living Energy Expenditure Estimation in Wheelchair Users with Spinal Cord Injury via Wearable Device-based Models
Authors: Ding Dan , Huang Zijian , Veerubhotla Akhila , DeLany James
Published: February 2024

Study Design
Cross-sectional validation study.
Objectives
To develop a raw acceleration signal-based random forest (RF) model for predicting total energy expenditure (TEE) in manual wheelchair users (MWUs) and evaluate the preliminary field validity of this new model along with four existing models published in prior literature using the Doubly Labeled Water (DLW) method.
Setting
General community and research institution in Pittsburgh, USA.
Methods
A total of 78 participants’ data from two previous studies were used to develop the new RF model. A seven-day cross-sectional study was conducted to collect participants’ free-living physical activity and TEE data, resting metabolic rate, demographics, and anthropometrics. Ten MWUs with spinal cord injury (SCI) completed the study, with seven participants having valid data for evaluating the preliminary field validity of the five models.
Results
The RF model achieved a mean absolute error (MAE) of 0.59 ± 0.60 kcal/min and a mean absolute percentage error (MAPE) of 23.6%±24.3% on the validation set. For preliminary field validation, the five assessed models yielded MAE from 136 kcal/day to 1141 kcal/day, and MAPE from 6.1–50.2%. The model developed by Nightingale et al. in 2015 achieved the best performance (MAE: 136 ± 96 kcal/day, MAPE: 6.1%±4.7%), while the RF model achieved comparable performance (MAE: 167 ± 99 kcal/day, MAPE: 7.4%±5.1%).
Conclusions:
Two existing models and our newly developed RF model showed good preliminary field validity for assessing TEE in MWUs with SCI and the potential to detect lifestyle change in this population. Future large-scale field validation study and model iteration is recommended.
An evaluation of the implementation, adoption, and uptake of a model of remote e-consent within the PRE-DX study
Authors: Northgraves Matthew , Bradley Paul , Huang Chao , Sumpter Sarah , Miah Jamal , Cain Henry , Cohen Judith
Published: February 2024

Background:
Remote electronic consent (e-consent) is an area of growing interest but questions remain about how to successfully implement this in clinical research. There are potential benefits from adopting remote e-consent, but uncertainty exists regarding the barriers and facilitators to wider use. PRE-DX is a randomised controlled trial, comparing the effect of changing the time point when the Oncotype DX genomic assay is ordered on the patient management pathway in early-stage breast cancer. In this paper, we evaluated the implementation, adoption, and uptake of a model of remote e-consent and explored the impact of patient demographics, method of e-consent and site research staff training on successful implementation.
Methods:
Remote e-consent was the primary consent method in PRE-DX, with remote postal consent and face-to-face consent available as alternatives. At the mid-point of recruitment, virtual researcher meetings were held to facilitate site recruitment during which polls using Microsoft teams and open discussions about staff’s experience of the e-consent process were conducted. Demographic information collected as part of PRE-DX was used to describe the characteristics of participants for each consent method. Continuous variable of age for each consent method and overall are described according to mean, standard deviation, median, interquartile range, and minimum and maximum values. Categorical variables of consent methods, gender and ethnicity and poll results from the researcher meetings are reported as frequencies and percentages.
Results:
Three hundred and forty-one participants were recruited to PRE-DX. The predominant consent method was e-consent (n=213), followed by face-to-face consent (n=119) and postal (n=9). The comparison of patient demographics showed that the age of participants was similar across groups (e-consent: mean 57.7 ± 10.2 years, median 59.0 (13) years; postal: mean 55.8 ± 11.9 years, median 52 (17.5) years; face-to face: mean 58.5 ± 10.4 years, median 57 (14) years). No concerns regarding the e-consent method were expressed during the researcher meetings, but uptake varied across sites.
Conclusion:
Remote e-consent can be successfully implemented for recruitment of patients of different ages and is acceptable to site research teams. Alternative consent methods should be available to maximise recruitment.
Trial Registration:
PRE-DX (ISRCTN14337451), registered 16th August 2022.
SPP1+ macrophages in HR+ breast cancer are associated with tumour-infiltrating lymphocytes
Authors: Lee Hee Jin , Cha Su Min , Park Jung-Wook , Lee Yoon Jae , Lee Hee Jae , Lee Hyeonjin , Lee In Won , Gong Gyungyub , Park Sung Hee , Jeong Byung-Kwan
Published: February 2024

Breast cancer, categorised into hormone receptor-positive (HR+), HER2- positive (HER2+), and triple-negative (TNBC) subtypes, exhibits varied outcomes based on the number of tumour-infiltrating lymphocytes (TILs). Increased TIL levels are associated with better outcomes in HER2+ and TNBC, while HR+ individuals with high TIL levels show shorter survival but greater neoadjuvant chemotherapy response. To explore the divergent roles of TIL levels across various subtypes and their effect on immune cell composition, we employed single-cell RNA sequencing on 31 patients with breast cancer. HR+ breast cancer with high TIL levels (TIL-high) revealed increased SPP1+ macrophages, increased SPP1 expression in other monocytes/macrophages (mono/macro) subgroups, and enriched pathways associated with extracellular matrix (ECM) remodelling in mono/macro. Moreover, cell–cell interaction analyses revealed enhanced SPP1, MIF, and FN1 signalling in the interaction between SPP1+ macrophages and T-cells in TIL-high HR+ breast cancer. Spatial transcriptomics data highlighted the close proximity of SPP1+ macrophages, CD8+ T-cells, and CD4+ T-cells in TIL-high HR+ breast cancer. Our findings unveil the novel influence of SPP1+ macrophages on T-cells in TIL-high HR+ breast cancer, potentially explaining the poor prognosis and offering insights for targeted interventions.
Structure-function analysis of time-resolved immunological phases in metabolic dysfunction- associated fatty liver disease
Authors: Schmidt-Christensen Anja , Eriksson Gustaw , Laprade William M. , Pirzamanbein Behnaz , Hörnberg Maria , Linde Kajsa , Nilsson Julia , Skarsfeldt Mark , Leeming Diana J. , Mokso Rajmund , Verezhak Mariana , Dahl Anders , Dahl Vedrana , Önnerhag Kristina , Oghazi Massoud Rezaee , Mayans Sofia , Holmberg Dan
Published: February 2024

Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions is multifaceted and involves complex interactions between metabolic, inflammatory, and genetic factors. Here we assess the underlying structural and molecular processes focusing on the immunological phase of MASH in the NIF mouse model and compare it to the human disease as well as other murine models. Histopathology together with synchrotron-radiation-based x-ray micro-computed tomography (SRµCT) was used to investigate structural changes within the hepatic sinusoids network in the NIF mouse in comparison to patients with different severities of MASH. A time-course, bulk RNA-sequencing analysis of liver tissue from NIF mice was performed to identify the dynamics of key processes contributing to the pathogenesis. Transcriptomics profiling of the NIF mouse revealed a gradual transition from an initially reactive inflammatory response to a regenerative, pro-fibrotic inflammatory response suggesting new avenues for treatment strategies that focus on immunological targets. Despite the lack of metabolic stress induced liver phenotype, a large similarity between the NIF mouse and the immunological phase of human MASH was detected. The translational value was further confirmed through comparative analyses with MASH patients and additional animal models. Finally, the impact of diets known to induce metabolic stress, was explored in the NIF mouse. An obesogenic diet was found to induce key physiological, metabolic, and histologic changes akin to those observed in human MASH.
Effectiveness of Minimally Invasive Sternal Compression Combined with the Nuss Procedure to Treat Pectus Carinatum Combined with Harrison Sulcus
Authors: Shang Zi Yin , Duan Xianlun , Hong Chun , Si Yuan
Published: February 2024

We aimed to investigate the feasibility of a minimally invasive sternal compression procedure c with Harrison sulcus treated from June 2015 to October 2022. All the patients underwent a minimally invasive sternal compression procedure combined with the Nuss procedure. The surgical conditions and postoperative outcomes of the patients and the satisfaction score of family members were analysed. Overall, the patients had a mean duration of surgery of 179.05 ± 36.01 min, intraoperative blood loss of 10.03 ± 2.77 mL, postoperative hospital stay of 6.89 ± 0.73 days, and postoperative satisfaction score of 89.4 ± 4.6. The incidence of surgical complications was 7.89%. The internal fixation stents were removed in 22 patients, and there was no recurrence during a follow-up 371.4 ± 6.3 days post-stent removal. These results were satisfactory. The use of a minimally invasive sternal compression procedure to treat this condition does not reduce the volume of the thorax after the procedure and results in an aesthetically pleasing incision, less complications, and fast postoperative recovery. Thus, it is a safe and effective method that is worthy of being promoted for clinical application.ombined with the Nuss procedure to treat pectus carinatum combined with Harrison sulcus. We retrospectively analysed the clinical data of 38 paediatric patients with pectus carinatum combined
Validating S100A16 as a prognostic and immunological biomarker in pan-cancer and lung adenocarcinoma through integrated Single-cell Sequencing Analysis
Authors: Shi Si , Yu Yao , Shang Yu , Wang Menghan , Xu Dandan , Chen Hong
Published: February 2024

Background
S100A16 belongs to the S100 protein family, exhibiting different expression levels across several human tumors. S100A16 upregulation in many malignancies suggests its potential role in malignant transformation. However, the specific involvement of S100A16 in lung adenocarcinoma (LUAD) remains unclear.
Methods
This study utilized RNA sequencing and protein expression data from the Cancer Genome Atlas (TCGA) and the Human Protein Atlas (THPA) databases to scrutinize the expression of S100A16 and its associations with patients’ prognosis, clinicopathological characteristics, tumor microenvironment (TME), immune cell infiltration, expression of immune checkpoint genes, and relevant signaling pathways in LUAD. Employing ESTIMATE and CIBERSORT algorithms alongside Gene Set Enrichment Analysis (GSEA), we investigated the underlying mechanisms by which LUAD is involved in the TME. Additionally, we used single-cell sequencing to measure the role of S100A16 at the cellular level and dissect the effect on treatment response in LUAD.
Results
S100A16 was highly expressed in LUAD. As an independent prognostic marker, S100A16 expression was correlated with adverse outcomes. Its expression levels were positively correlated with the clinical TN stage and LUAD grade. GO and KEGG analyses revealed the predominance of molecules positively associated with S100A16 expression in LUAD, concentrating on pathways related to cellular signaling, motility, morphology, and cell interactions. The high S100A16 group showed a significantly higher TME score compared with the low S100A16 expression group. Immune cells, including M1 macrophages, memory B cells, activated NK cells, plasma cells, and naive B cells, were positively associated with S100A16 expression in LUAD. Furthermore, a positive correlation was observed between S100A16 and the expression of most immune checkpoint genes. Patients with high S100A16 expression demonstrated lower IC50 values for drugs such as 5-fluorouracil, bortezomib, cisplatin, cytarabine, docetaxel, doxorubicin, etoposide, and vinorelbine, suggesting that S100A16 overexpression increased sensitivity to these treatments in LUAD. This study provides novel insights into the role of S100A16 in LUAD and associated signaling pathways.
Conclusions
S100A16 is an independent prognostic marker in LUAD, intricately linked to the TME, immune cell infiltration, immune checkpoint expression, and response to treatment. This study underscores the potential of S100A16 as a prognostic marker in LUAD, advancing cancer treatment.
Assessment of the Association of Repeated Vaginal Examination with Early Onset Neonatal Sepsis Hospital Based Follow Up Study
Authors: Lemma Ketsela , Berhane Yemane
Published: February 2024

Background: Sepsis is the 3rd leading cause of neonatal mortality in Ethiopia contributing for 16 % of neonatal death. Ina hospital study neonatal sepsis was the leading diagnosis at admission and second leading cause of neonatal death at the neonatal intensive care unit. Among other factors repeated vaginal examination during labor is known to contribute for sepsis in low-income settings. However, there is limited evidence in the Ethiopian setting.
Objective: The objective of this study was to examine the association between number of vaginal examination and early onset neonatal sepsis.
Methods: The study was conducted at Gandhi memorial Hospital, a public maternity and newborn care hospital. We followed 672 mother newborn pairs by phone until 7 days of age to detect clinical sepsis. Data were analyzed using SPSS version 20 software. Adjusted odds ratio (AOR) with corresponding 95% confidence interval (CI) was used to show strength of associations and variables with p value <0.05 were considered to be statistically significant.
Results: The incidence of early onset neonatal sepsis was found to be 20.83% (95% CI 17.60, 24.00). Having a frequent vaginal examination (four or more times) during labor and delivery was strongly associated with development of early onset neonatal sepsis, (ARR 2. 69 ;95 CI: 1.08, 6.70 ) after controlling for some common other risk factors including premature rupture of membrane and induced labor.
Conclusion: Frequent digital vaginal examination significantly increases the risk of early onset neonatal sepsis. Health professionals caring for laboring mother must limit the number of vaginal examinations to reduce the risk of neonatal sepsis which has a huge negative implication on the survival of the newborns. We also recommend further study using either cord blood or neonatal blood culture to better diagnose early onset neonatal sepsis objectively.