bluuebunny/crossref_metadata_2025 huggingface dataset:
Tunnel Technique in Bone Augmentation Procedures for Dental Implant Rehabilitation: A Systematic Review
Authors: Sivolella Stefano , Brunello Giulia , Castagna Dario Azeglio , Cavallin Francesco , Consolo Ugo
Published: December 2024

Background/Objectives: This systematic review aimed to compare the tunnel technique for pre-implant bone regeneration with traditional flap techniques also involving a crestal incision, in terms of procedure success, graft healing, postoperative course, patient satisfaction, and implant follow-up. Methods: A systematic search was conducted on MEDLINE/PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials following PRISMA guidelines, searching for comparative prospective and retrospective studies in English, published between January 2002 and April 2024. The population of interest consisted of patients with edentulous ridge atrophy requiring pre-implant bone regeneration. The primary outcome was the success of the procedure. The secondary outcomes included complications, patient comfort, graft resorption, bone gain, primary implant stability, implant success/survival, peri-implant bone level change, and operative time. The risk of bias was assessed using RoB2 and ROBINS-I. Results: The search and selection process yielded one randomized controlled trial and three comparative observational studies, all with serious/high risk of bias. A narrative synthesis was conducted due to the small number of studies and the heterogeneity in key features. The tunnel technique might provide some advantages in terms of the success of the procedure, but the findings were not statistically significant. Conflicting findings or non-significant differences were reported in terms of the secondary outcomes. Conclusions: This review suggested some potential advantages of the tunnel technique for bone augmentation over traditional techniques involving a crestal incision, but the limited quality and amount of data precluded any definitive conclusions.
The Quantum Zeno Capacity and Dynamic Evolution Mode of a Quantum System
Authors: Ni Zhenbo , Peng Yonggang , Zheng Yujun
Published: December 2024

The quantum Zeno effect (QZE) is widely employed in quantum engineering due to the issue of frequent measurements freezing a quantum system. In this study, the quantum Zeno factor is introduced to characterize the quantum Zeno capacity of a quantum system. The quantum Zeno factor reveals that the quantum Zeno effect is dependent on the evolution mode of quantum states, which is semi-irrelevant to conventional energy uncertainty and extends the QZE domain. The Zeno factor provides a new consideration to qualify the (anti-)Zeno capacity of a quantum system for its applications: a large quantum Zeno factor value indicates that a quantum system is of a QZE quality. The numerical results of the quantum Zeno capacity are shown using two typical examples: tailing the dynamic evolution modes using the quantum Zeno factor in a three-level system, and quantifying the message exchange between qubits in a coupled qubit system using a quantum Zeno factor.
Correction: Chen et al. Exploring the Literacy Experiences of Preservice Early Childhood Teachers: Social and Contextual Influences, and Implications for Teacher Education. Educ. Sci. 2024, 14, 1042
Authors: Chen Jennifer J. , Ren Yonggang , O’Neill Shirley
Published: December 2024

In the original publication [...]
Analysis of Supraharmonics Emission in Power Grids: A Case Study of Photovoltaic Inverters
Authors: Pinto João , Grasel Bernhard , Baptista José
Published: December 2024

High-frequency (HF) emissions, referred to as supraharmonics (SHs), are proliferating in low- and medium-voltage networks due to the increasing use of technologies that generate distortions in the 2 kHz to 150 kHz range. The propagation of SHs through the electrical grid causes interference with power supply components and end-user equipment. With the increasing frequency of these incidents, it is imperative to establish guidelines and regulations that facilitate diagnosis and limit the amount of emissions injected into the electrical grid. The proliferation of SH emissions from active power electronics devices is a significant concern, especially considering the growing importance of photovoltaic (PV) systems in the context of climate change. The aim of this paper is to address and analyze the emissions from different PV inverters present in an electrical network. Several scenarios were simulated to understanding and identifying possible correlations. This study examines real signals from PV systems, which exhibit narrowband, broadband and time-varying emissions. This paper concludes by emphasizing the need for specific regulations for this frequency range while also providing indications for future research.
Damping of Flying Capacitor Dynamics in Multi-Level Boost DC-DC Converters
Authors: Buso Simone , Rossetto Leopoldo
Published: December 2024

This paper presents a novel modeling approach for flying capacitor dynamics in boost-type multi-level converters (FCML-boosts) controlled by Phase Shift Pulse Width Modulation (PSPWM). By explicitly taking into account the interaction between the inductor current and the flying capacitor voltage, the model is able to reveal an underlying resonance phenomenon and to predict its frequency at each operating point. Based on such a model, whose derivation is explained in detail, both passive and active damping solutions are proposed, designed, and experimentally verified that significantly reduce the undesirable oscillations. The analytical results and the devised control solutions are tested on a 1kW, four-level, boost DC-DC converter prototype employing 200V, 48A rated EPC2034C GaN devices.
An Efficient Dual Application of the Adaptive Cross Approximation for Scattering and Radiation Problems
Authors: García Eliseo , Delgado Carlos , Cátedra Felipe
Published: December 2024

This paper presents a computationally efficient approach for the solution of electromagnetic problems based on the combination of the Characteristic Basis Functions and Adaptative Cross Approximation, allowing an improvement of the processing time and memory requirements with respect to the conventional MoM and CBFM approaches. The presented technique has been validated using a number of cases in order to assess its accuracy and efficiency.
Unpacking How Natural Gas, Digital Growth, and Hydro-Based Energy Sources Impact Ecological Sustainability in Egypt
Authors: Elmanaei Hala Mohamed Sh , Khalifa Wagdi M. S. , Berberoğlu Ayşen
Published: December 2024

Egypt, as a nation, is committed to achieving ecological sustainability, which helps to protect the environment for future generations, thereby ensuring a balance between energy production, environmental health, and economic development. With regard to this vision, this research utilized the autoregressive distributed lag (ARDL) estimator to probe how hydroelectricity, digitalization, and natural gas affect ecological degradation within the Environmental Kuznets Curve (EKC) in Egypt. This study further used two distinct environmental proxies, namely, CO2 emissions and the ecological footprint. The result of the ARDL estimator indicates that there is an inverted U-shaped association between economic growth and environmental sustainability, while urbanization does not affect environmental sustainability. Moreover, hydroelectricity, digitalization, and natural gas negatively impact environmental sustainability in Egypt. Furthermore, the frequency domain causality approach showed that there is a two-way causality pathway between environmental sustainability and its regressors. Based on this outcome, policymakers should prioritize decoupling economic growth from environmental degradation by investing in green infrastructure, sustainable industries, and circular economy models.
Hybrid Proximal Policy Optimization—Wasserstein Generative Adversarial Network Framework for Hosting Capacity Optimization in Renewable-Integrated Power Systems
Authors: Han Jun , Cai Chao , Pan Wenjie , Liu Hong , Xu Zhengyang
Published: December 2024

The rapid integration of distributed energy resources (DERs) such as photovoltaics (PV), wind turbines, and energy storage systems has transformed modern power systems, with hosting capacity optimization emerging as a critical challenge. This paper presents a novel Hybrid Proximal Policy Optimization-Wasserstein Generative Adversarial Network (PPO-WGAN) framework designed to address the temporal-spatial complexities and uncertainties inherent in renewable-integrated distribution networks. The proposed method combines Proximal Policy Optimization (PPO) for sequential decision-making with Wasserstein Generative Adversarial Networks (WGAN) for high-quality scenario generation, enabling robust hosting capacity enhancement and operational efficiency. Simulation results demonstrate a hosting capacity improvement of up to 128.6% in high-penetration scenarios (90% renewable), with average operational cost reductions of 22%. Voltage deviations are minimized to within ±5% of nominal levels, while energy losses are reduced by 18%. Scenario quality, evaluated using the Wasserstein metric, achieved convergence with an average score of 0.95 after 80 iterations, highlighting the WGAN’s ability to generate realistic and diverse scenarios. This study advances the state of the art in distribution network optimization by integrating machine learning techniques with robust mathematical modeling. The PPO-WGAN framework enhances scalability, ensures grid stability, and promotes efficient renewable integration, providing a robust foundation for future applications in modern power systems.
Variability of Material Solutions for the Perimeter Walls of Buildings in Post-Industrial Settlements as Part of Energy Rehabilitation and Achieving Carbon Neutrality
Authors: Afsoosbiria Hamed , Kubečková Darja , Musenda Oskar Kambole , Mohamed Khaled
Published: December 2024

Post-industrial sites are a part of many cities. The impacts of industrial activities are not only evident in the area where the activity took place, but also affect the buildings within these areas. Buildings that served the industry in the past were built mainly by mass construction methods. From today’s point of view, these buildings are unsatisfactory in terms of typology, operation, and energy. In particular, energy rehabilitation is a way to restore industrial buildings and bring them to a full-fledged state. This issue is documented in a case study of a city affected by underground mining activity and on a selected skeleton construction. Given that industrial buildings have heavy or mass structures where some elements like beams and columns are damaged, it is crucial to consider not only energy solutions, but also the structural and architectural aspects of these buildings. In terms of thermal engineering and energy, including the renovation of structures, a software-supported evaluation of three material variants for the envelope walls of the skeleton construction from the 1970s was conducted. This study evaluates the thermal performance of conventional, proposed, and traditional wall designs by analysing their U-values, thermal resistance, and structural advantages. The results reveal that the conventional wall, featuring a 150 mm EPS 70 NEO insulation layer, achieves the lowest U-value, outperforming the proposed wall by a factor of 1.2 in thermal resistance. Both designs significantly reduce U-values compared to traditional walls, by factors of 6.55 and 5.40, respectively. Despite a 23% reduction in thickness relative to the conventional wall (and 44% compared to traditional walls), the proposed wall demonstrates robust thermal performance. Further benefits include reduced structural dead load, with the conventional and proposed walls being 3.70 times lighter per square meter than traditional walls. This reduction can decrease foundation, column, and beam dimensions, optimizing building design. Thermal bridging analysis highlights superior corner insulation in conventional walls due to higher surface temperatures, while the proposed wall maintains effective insulation with surface temperatures close to indoor conditions. Overall, the findings underscore the importance of advanced materials in achieving efficient thermal performance while balancing architectural and structural demands. The results achieved from the experimental work show that industrial buildings can be effectively energy-renovated in a way that complies with legislative documents, successfully extends the physical life of the frame structures, and contributes to carbon neutrality.
Challenges for Implementing Vehicle-to-Grid Services in Parking Lots: A State of the Art
Authors: Comi Antonio , Elnour Elsiddig
Published: December 2024

Electric vehicles (EVs) play a vital role in the transition to renewable energy and decarbonisation, and there is increasing global interest in expanding their use. However, the growing number of EVs poses challenges to the electricity grid due to increasing energy demand. Vehicle-to-grid (V2G) technology can address these issues by allowing for EVs to charge and discharge energy, thus helping to balance the grid when needed. Aggregating vehicles in designated parking areas optimises energy transfer, making it crucial to identify suitable parking locations and forecast the energy available from parked vehicles. A spatial–temporal framework ensures that V2G services operate efficiently considering both the location and the timing of vehicle parking. This paper reviews studies on temporal–spatial V2G parking demand, identifying high-demand areas such as shopping centres and workplaces, where vehicles park for extended periods. Strategic locations of V2G hubs in these areas ensures seamless integration into existing mobility patterns without disrupting users’ routines. In addition, this review examines user acceptance, technical feasibility, and V2G’s role in reducing grid demand peaks. The findings indicate the potential of effectively implemented V2G services to enhance electricity grid stability and efficiency while minimising disruptions to EV users.
An Action Evaluation Method for Virtual Reality Simulation Power Training Based on an Improved Dynamic Time Warping Algorithm
Authors: Xu Qingjie , Liu Yong , Li Shuo
Published: December 2024

To address the shortcomings in action evaluation within VR simulation power training, this paper introduces a novel action recognition and evaluation method based on dynamic recognition of finger keypoints combined with an improved Dynamic Time Warping (DTW) algorithm. By constructing an action recognition model centered on hand keypoints, the proposed method integrates distance similarity and cosine similarity to account comprehensively for both numerical differences and directional consistency of action features. This approach effectively tackles the challenges of feature extraction and recognition for complex actions in VR power training. Furthermore, a scoring mechanism based on the improved DTW algorithm is proposed, which employs Gaussian-weighted feature-derivative Euclidean distance combined with cosine similarity. This method significantly reduces computational complexity while improving scoring accuracy and consistency. Experimental results indicated that the improved DTW algorithm outperformed traditional methods in terms of classification accuracy and robustness. In particular, cosine similarity demonstrated superior performance in capturing dynamic variations and assessing the consistency of fine hand movements. This study provides an essential technical reference for action evaluation in VR simulation power training and offers a scientific basis for advancing the intelligence and digitalization of power VR training environments.
Complex and Nonlinear Dynamics in Electrical Power and Energy Storage Systems: Analysis, Modeling and Control
Authors: Lopes António M. , Li Penghua , Pires Eduardo José Solteiro , Chen Liping
Published: December 2024

Energy demand has been increasing, and environmental concerns associated with energy consumption have emerged worldwide [...]
Research on Transient Characteristics of an Aviation Starter Motor Under Low Temperature and Pressure
Authors: Tian Wei , Wang Lin , Bai Xin , Han Zhiqiang , Zuo Zinong , Wu Xueshun , Wu Yi , Yan Yan , Fang Jia
Published: December 2024

To enhance the performance of aviation piston engine starters in high-altitude environments, this study investigated their transient starting characteristics under low-temperature and low-pressure conditions using a high-altitude simulation chamber. Experiments were conducted across ambient temperatures from −60 to 15 °C and pressures from 35 to 95 kPa. The results show that the ambient temperature significantly impacts the transient characteristics of the motor, particularly at the initiation stage, whereas pressure has a weaker effect. For every 5 °C drop in temperature, the peak starting current increases by 1.95 A. From 15 to −60 °C, the maximum difference in the starting current pulse width is 11.64 ms. Furthermore, as the ambient temperature decreases, the average current after the motor stabilizes increases, and the average speed decreases.
A Reordering Buffer Management Method at Edge Gateway in Hybrid IP-ICN Multipath Transmission System
Authors: Liu Yuqi , Han Rui , Wang Xu
Published: December 2024

Multipath transmission in ICN provides high transmission efficiency and stability. In an IP-ICN compatible network environment, unmodified IP terminal devices can access ICN through gateways, benefiting from these performance enhancements. This paper proposes a gateway framework for hybrid IP-ICN multipath transmission systems, enabling protocol conversion and quality of service management. A packet reordering module is integrated at the egress gateway to address complex packet disorder issues caused by ICN multipath transmission, thereby enhancing the service quality provided to IP terminals. A Reordering Buffer Management Method (RBMM) is introduced, consisting of two key components. First, RBMM employs an improved dynamic threshold scheme for reserved buffer partitioning, efficiently identifying congestion and optimizing buffer resource utilization. Second, a flow-priority-based replacement strategy is designed to enhance fairness in resource allocation by evicting packets with lower delivery probability during congestion. Experimental results demonstrate that RBMM dynamically adapts to varying traffic conditions, maintaining high transmission performance while reducing buffer resource consumption. In comparison to existing methods, RBMM significantly reduces queuing delay and flow completion time, providing more balanced resource allocation when multiple flows compete for limited buffer capacity.
Comparative Genomic Analysis of Bacillus velezensis BRI3 Reveals Genes Potentially Associated with Efficient Antagonism of Sclerotinia sclerotiorum (Lib.) de Bary
Authors: Liu Yaoyao , Yin Changyan , Zhu Min , Zhan Yuhua , Lin Min , Yan Yongliang
Published: December 2024

Background/Objectives: Bacillus velezensis has recently received increased attention as a potential biological agent because of its broad-spectrum antagonistic capacity against harmful bacteria and fungi. This study aims to thoroughly analyze the genomic characteristics of B. velezensis BRI3, thereby providing theoretical groundwork for the agronomic utilization of this strain. Methods: In this work, we evaluated the beneficial traits of the newly isolated strain B. velezensis BRI3 via in vitro experiments, whole-genome sequencing, functional annotation, and comparative genomic analysis. Results: B. velezensis BRI3 exhibits broad-spectrum antifungal activity against various soilborne pathogens, displays inhibitory effects comparable to those of the type strain FZB42, and exhibits particularly effective antagonism against Sclerotinia sclerotiorum (Lib.) de Bary. Whole-genome sequencing and assembly revealed that the genome of BRI3 contains one chromosome and two plasmids, which carry a large amount of genetic information. Moreover, 13 biosynthetic gene clusters (BGCs) involved in the biosynthesis of secondary metabolites were predicted within the BRI3 genome. Among these, two unique BGCs (cluster 11 and cluster 13), which were not previously reported in the genomes of other strains and could potentially encode novel metabolic products, were identified. The results of the comparative genomic analysis demonstrated the genomic structural conservation and genetic homogeneity of BRI3. Conclusions: The unique characteristics and genomic data provide insights into the potential application of BRI3 as a biocontrol and probiotic agent.
Lamina Propria and GALT: Their Relationship with Different Gastrointestinal Diseases, Including Cancer
Authors: Surd Adrian Onisim , Răducu Camelia , Răducu Eugen , Ihuț Andrada , Munteanu Camelia
Published: December 2024

The structural integrity of the gastrointestinal tract is important because it dictates the functionality of this system. Regarding this, gut-associated lymphoid tissue (GALT) has a significant role in immunity. Most cancer research focuses on organized lymphoid structures and less on diffuse structures such as the lamina propria (LP). Therefore, this paper aims to investigate the link between the LP and cancer in humans. The interstitial matrix and loose connective tissue layer located directly under the epithelium is known as the LP. In this area, there are a lot of IgA+ plasma cells (PCs), T and B lymphocytes, macrophages, dendritic cells (DCs), and stromal cells (SCs). Antigens from the lumen are picked up by LP DCs and presented directly to B cells, which may cause IgA class switching and differentiation in the presence of T cells. In humans, the GALT of the mucosa has been proposed as the source of a unique malignancy known as “GALT carcinoma”, which is thought to represent the “third pathway of colorectal carcinogenesis”. However, present colorectal cancer classifications do not define GALT carcinoma as a separate histologic category.
Ideological Consistency and News Sharing as Predictors of Masking Among College Students
Authors: Holz Adrienne
Published: December 2024

During the COVID-19 pandemic, the United States Centers for Disease Control and Prevention (CDC) recommended the use of well-fitting face masks or respirators as a strategy to reduce respiratory transmission; however, acceptance and utilization of face masks quickly became a contentious, politically charged matter. Given the effectiveness of masking against respiratory viruses, it is critical to understand the various normative factors and personal values associated with mask wearing. To this end, this study reports the findings of an online, cross-sectional survey (n = 1231) of college students during the COVID-19 pandemic. Findings show that ideological consistency, sharing news to create awareness, and sharing unverified news significantly predict masking behaviors, though ideological consistency most substantially explained variance in self-reported masking behaviors. Participants with more liberal political ideologies reported greater adherence to masking policies while those with more conservative ideologies reported less mask-wearing behavior. A better understanding of the predictors of masking behaviors, particularly how political ideologies continue to shape public health responses, is essential for designing more effective communication strategies to control disease spread and help inform strategies for future outbreaks. Study implications and limitations are discussed.
Malaria Prevention for Pregnant Women and Under-Five Children in 10 Sub-Saharan Africa Countries: Socioeconomic and Temporal Inequality Analysis
Authors: Okova Denis , Lukwa Akim Tafadzwa , Oyando Robinson , Bodzo Paidamoyo , Chiwire Plaxcedes , Alaba Olufunke A.
Published: December 2024

Background: Malaria remains a public health challenge in low- and middle-income countries (LMICs). Despite gains from strategies like Insecticide-Treated Nets (ITNs) and Intermittent Preventive Treatment during pregnancy (IPTp), significant socioeconomic inequalities persist, particularly among pregnant women and children under five. This study analyzed temporal and socioeconomic inequalities in malaria prevention in sub-Saharan Africa (SSA). Methods: Nationally representative Demographic Health Surveys from 10 SSA countries (Mozambique, Burkina Faso, Tanzania, Côte d’Ivoire, Madagascar Kenya, Rwanda, Nigeria, Uganda, and Cameroon) were used, comparing two time periods. Changes in ITN use by pregnant women and children under five, as well as IPTp coverage, were assessed. Inequalities based on socioeconomic status (SES) and residence were analyzed using the Erreygers Normalized Concentration Index and Theil index. Results: The results revealed significant variability in ITN use and IPTp coverage within countries. Eight countries showed improvements in ITN use during pregnancy, with Nigeria seeing a 173.9% increase over five years. Burkina Faso and Tanzania consistently reported high ITN use (~87%) in children under five. IPTp coverage increased in all countries except Kenya. Decomposition using the Theil index indicated that within-group inequalities, particularly based on SES and residence, were the primary drivers of disparities. Conclusions: To ensure progress toward universal health coverage, malaria prevention programs must prioritize vulnerable populations and be continuously evaluated.
Fear of Childbirth Among Pregnant People Facing Anti-Fat Bias
Authors: Roosevelt Lee , Maguire Sarah , Sharma Akshay , Zielinski Ruth
Published: December 2024

Explicit and implicit anti-fat biases are widespread among healthcare providers, leading to significant negative consequences for pregnant people, including poorer health outcomes. Fear of childbirth (FOC) can affect the length of labor, increase the risk of cesarean delivery, and negatively influence a new parent’s perception of infant bonding. This study investigated the impact of perceived anti-fat bias on FOC among pregnant people. Data were gathered from 329 pregnant people recruited from three large academic prenatal centers in the United States and via social media. Participants completed a survey that included validated instruments measuring perceptions of anti-fat bias and FOC. Participants perceiving anti-fat bias reported higher FOC. Black participants perceiving anti-fat bias reported higher FOC. These findings suggest that perceived anti-fat bias from providers is associated with FOC for pregnant people, particularly those who identify as Black. Interventions to educate providers on these important concepts could help improve pregnant people’s experience within the healthcare system.
Spatial Planning Strategies for Urban Ecology and Heritage Conservation in Macau: An Investigation of Ultra-High-Density Cities
Authors: Li Jitai , Lin Fan , Yang Shuai , Chen Yile
Published: December 2024

Urban ecology and heritage-protection space are important parts of urban land and should be highly emphasized in urban planning. Improving and upgrading the level of urban ecological and heritage-conservation space will directly affect the level of spatial quality of the built environment of the city. As a high-density city, Macau suffers from “urban diseases” such as a low per capita green space rate and poor quality of the human environment. Therefore, in order to solve this kind of urban disease, the green environment quality of Macau’s heritage space should be improved and more leisure and recreational space should be provided for urban residents. This paper examines the layout of cultural heritage open spaces in Macau and suggests strategies for planning the preservation and use of these critical resources. This study investigated the current status of open space resources in Macau’s offshore islands, cultural heritage space resources, eight Largo spaces (“Largo” is a unique term for urban public open space in Macau) in Macau’s historic city, site-based cultural heritage open spaces, and the current status of rural walking trails in the offshore islands’ ecological reserves, and used GIS technology to visualize the survey results. Last, this paper investigates the planning strategy for the sustainable use of Macau’s outlying island ecological reserves and proposes a “green network” to connect the main mountains, green areas, and coastal wetlands in Coloane with the natural space. In view of the heritage-conservation space of the Macau Peninsula, this paper proposes the planning strategy of constructing linear landscape and cultural routes and planning characteristic heritage streets and alleys. Through using cultural heritage buildings as nodes and connecting pedestrian streets and alleys, the planning mode of combining heritage attractions and streets and alleys is realized.
Low-Fat Tenebrio molitor Meal as a Component in the Broiler Diet: Growth Performance and Carcass Composition
Authors: Petkov Evgeni , Popova Teodora , Dimov Krasimir , Vlahova-Vangelova Desislava , Balev Desislav , Kolev Nikolay , Dragoev Stefan
Published: December 2024

Tenebrio molitor is considered a sustainable protein source for diets in poultry. It has been investigated in regard to the performance, health status, and product quality in different poultry species. This study was designed to evaluate the effect of low-fat Tenebrio molitor meal (LFTM) included in the broilers’ diet on the growth performance and carcass composition of the birds. The trial was conducted at the Institute of Animal Science-Kostinbrod, Bulgaria. A total of 120 male one-day-old Ross 308 broilers were allocated to 5 groups. After an adaptation period of 14 days, the birds were fed a basal diet (C) and diets including LFTM in amounts of 2.5% (T2.5), 5% (T5), 7.5% (T7.5), and 10% (T10). The growth performance of the birds was measured during the trial. At 35 days of age, 8 birds per group were slaughtered, and their carcass quality was evaluated. We found a linear response of BWG and FCR towards the inclusion of Tenebrio molitor meal (TM) in the diet. For the whole period (14–35 d), the BWG decreased (p = 0.0002), while the values of FCR increased (p = 0.0001) with the increase in the levels of the insect meal. The doses of 7.5% and 10% of the insect meal were associated with lower carcass weight and also decreased the yield of the breast. The results of the study indicated that the incorporation of LFTM, especially in amounts of 7.5–10%, could not be appropriate for broilers due to adverse effects on the growth performance and carcass composition.
Does Continuous Renal Replacement Therapy with oXiris in Septic Shock Have Any Positive Impact? Single-Centre Experience with oXiris Therapy in Septic Shock Patients
Authors: Mielnicki Wojciech , Dyla Agnieszka , Zając Marta , Rokicka-Demitraszek Natalia , Smereka Jacek
Published: December 2024

Background: Renal replacement therapy with an oXiris hemofilter may be helpful for patients with acute kidney injury in conjunction with sepsis and septic shock. The aim of this study was to assess the impact of an oXiris membrane on septic shock patients. Methods: All renal replacement therapies with oXiris (Baxter, Deerfield, IL, USA) performed between January 2018 and August 2021 were retrospectively analyzed. CRRT was initiated in continuous venovenous hemodiafiltration (CVVHDF) mode using Prismaflex System (Baxter). Demographic data, starting point of infection, source control, etiology, and course of treatment were analyzed. Results: A total of 32 patients were included in the study. Most patients treated with oXiris had acute kidney injury (AKI) and required CRRT. One patient had KDIGO 1 AKI (3.1%), three patients (9.4%) had KDIGO 2 AKI, and 28 patients (87.5%) had KDIGO 3 AKI. A statistically significant decrease in vasopressin dosage was required to achieve adequate MAP after 24 and 72 h, and a statistically significant decrease in norepinephrine dosage after 72 h was observed, with no SOFA score change on days 2 and 3. Procalcitonin and lactate levels did not change after 24 and 72 h. No beneficial effect on mortality was observed. Conclusions: Treatment with an oXiris membrane can positively impact vasopressors’ requirement but not influence SOFA score, procalcitonin or lactate levels, or mortality in septic shock patients.
Advancements in Minimally Invasive Techniques and Biomarkers for the Early Detection of Endometrial Cancer: A Comprehensive Review of Novel Diagnostic Approaches and Clinical Implications
Authors: Asaturova Aleksandra , Zaretsky Andrew , Rogozhina Aleksandra , Tregubova Anna , Badlaeva Alina
Published: December 2024

This review evaluates the advances in the early detection and diagnosis of endometrial cancer (EC), emphasizing the growing importance of minimally invasive techniques and novel biomarkers. Current diagnostic protocols for EC rely heavily on invasive procedures such as transvaginal ultrasound (TVU), hysteroscopy, and endometrial biopsy, which, although effective, can be overly burdensome for patients and inefficient for asymptomatic or low-risk populations. As there is no consensus on EC screening in high-risk or general populations, recent studies have explored alternative methods using biofluids and genomic biomarkers to improve sensitivity and specificity and facilitate access for patients. This review summarizes findings on DNA methylation markers, circulating tumor-derived nucleic acids, and the potential of liquid biopsy approaches for the early detection of EC. These innovations may not only streamline screening but also reduce the need for invasive procedures. This review highlights the potential of these biomarkers to be integrated seamlessly into the existing cervical cancer screening programs, which could transform screening methods for endometrial cancer and support the development of personalized, less invasive diagnostic procedures.
Review of Supplements That Patients Commonly Report Using for Dementia
Authors: Frolov Alexander , Wadood Audrey , Kelley Brendan J.
Published: December 2024

Dietary supplements are readily available over the counter in the United States and are used by the majority of older adults to address a variety of concerns and conditions. Many older adults report using dietary supplements for cognitive health—either to address memory loss or dementia or in efforts to prevent cognitive decline. Our objective for this narrative review is to summarize the available efficacy and safety data for several supplements commonly reported in our clinic as being used for symptoms of dementia. Using a validated survey instrument, we conducted a survey of patients in our tertiary referral center memory clinic population to assess for the most commonly reported supplements for cognition. In our review, we compare the strength of published medical and scientific evidence to advertising or other lay press claims made about the nine most reported supplements with the aim of providing a representation of general trends in this industry. We found little or no scientific evidence available to support the use of any of these substances to ameliorate memory loss or other cognitive symptoms. Although most appear safe in the studies conducted to date, several authors have highlighted the lack of Food and Drug Administration oversight in the supplement industry, raising concerns over unknown or undeclared contaminants in these over-the-counter products. This review will better prepare clinicians to discuss these considerations with their patients who are considering the use of dietary supplements.
Assesment of Salivary and Serum Levels of HBD2 in Patients with Chronic Angioedema
Authors: Štrajtenberger Maja , Lugović-Mihić Liborija , Stipić-Marković Asja , Artuković Marinko , Glavina Ana , Pravica Nika Barbara , Hanžek Milena , Sušić Tamara , Tešija Kuna Andrea , Nađ Bungić Lara
Published: December 2024

Background/Objectives: Human β-defensin 2 (HBD2) is a protein that plays an important role in activating the immune system by modulating spinal pathways and the inflammatory response. According to previous research, HBD2 was proven to be important in chronic spontaneous urticaria (CSU) (their values were significantly elevated in CSU patients, with a significant correlation between HBD2 levels and the percentage of peripheral basophils, suggesting that elevated HBD2 levels may be a potential marker of basophil and mast cell activation), which led us to additional research on the HBD2 molecule in isolated chronic angioedema. The aim of this research is to examine HBD2 values in the saliva and serum of patients with isolated angioedema, as a potential biomarker of the disease. Methods: This cross-sectional study involved a total of 102 participants, involving three groups: 33 patients with isolated chronic non-hereditary angioedema (AE) (defined as sudden onset of localized edema without chronic urticaria), 33 patients with angioedema associated with chronic urticaria (CU+AE), and 35 healthy participants (controls, CTRL). They provided a saliva sample to determine HBD2 levels using an ELISA (Enzyme-Linked Immunosorbent Assay). Subsequently, a peripheral blood sample (serum) was taken from the participants to determine HBD2 levels using the same ELISA. Results: Salivary HBD2 levels were significantly higher in those with CU+AE than in the CTRL (p = 0.019). While salivary HBD2 values differed between those with angioedema and CTRL, the serum HBD2 values did not. Also, no correlation between the levels of HBD2 in saliva and serum was found. Conclusions: Since we found that salivary HBD2 values were significantly higher in those with CU+AE than in CTRL, this points to a possible role of the HBD2 molecule in pathogenesis of AE (namely, that it induces degranulation in mast cells and vascular permeability, and has antimicrobial properties) Therefore, more research is needed to determine how reliable salivary HBD2 measurement is, as well as its significance.
Spatio-Temporal Variation and Drivers of Land-Use Net Carbon Emissions in Chengyu Urban Agglomeration, China
Authors: Wang Wen , Wang Xin , Wang Li , Zhang Zhihua , Lyu Daren
Published: December 2024

Land-use change is an important cause of carbon emissions (CEs). In the context of achieving carbon peaking and carbon neutrality goals, understanding the coupling mechanisms between land-use change and CEs is of great significance for fostering regional low-carbon sustainable development. In this study, the land-use net carbon emissions (LCN) calculation and evaluation model was built based on the perspective of land-use change. The land-use variation matrix, standard deviation ellipse, and spatial autocorrelation analysis were used to analyze the spatio-temporal evolution of land-use and the LCN in the Chengyu urban agglomeration (CUA) from 2000 to 2020. Meanwhile, the economic contribution coefficient and ecological support coefficient were applied to evaluate the alignment among the CEs, socio-economic development, and the ecological environment. In addition, the modified Kaya and Logarithmic Mean Divisia Index (LMDI) models were used to quantitatively analyze the drivers and underlying influence mechanisms of the LCN. The results showed the following: (1) The area of built-up land and forest land expanded rapidly, mainly transforming grassland and farmland to built-up land and forest land in the CUA during the study period. The built-up land was the main source of the regional CEs. The land-use changes led to the migration of the LCN center and the variations in spatial clustering. (2) The growth rate of the LCN decreased after 2010, and the disparities in carbon productivity and the carbon compensation rate among the cities gradually narrowed from 2000 to 2020. The alignment among the regional CEs, socio-economic development, and ecological environmental governance was effectively improved. (3) The economic development level and energy consumption intensity were the primary facilitator and inhibitor of the LCN, respectively. The results could offer valuable references and insights for formulating regional carbon reduction strategies and policies.
CRISPR/Cas9 Edition of the F9 Gene in Human Mesenchymal Stem Cells for Hemophilia B Therapy
Authors: Lara-Navarro Irving Jair , Jave-Suárez Luis Felipe , Marchal Juan Antonio , Jaloma-Cruz Ana Rebeca
Published: December 2024

Hemophilia B is a genetic disorder characterized by clotting factor IX deficiency and bleeding in joints and muscles. Current treatments involve intravenous infusion of plasma-derived products or recombinant proteins, which have limited efficacy due to the short half-life of infused proteins. Recently, gene therapy for bleeding disorders has offered a potential solution. This study aimed to develop an in vitro gene therapy model using the CRISPR/Cas9 system to incorporate the F9 cDNA in human mesenchymal stem cells (hMSCs) to produce clotting factor IX. RNA guide sequences targeting the promoter-exon 1 region of the F9 gene were designed to incorporate a wild-type F9 cDNA into the cells. Knockin was performed with the CRISPR/Cas9 system and pDONOR-CMV/cDNAF9/IRES/EGFP vector template recombination in Lenti-X HEK293 cells and MSCs. A lentiviral F9 cDNA vector was designed as a FIX secretor model to validate the CRISPR/Cas9 system. Results showed successful gene editing and F9 expression in both cell models, although editing efficiency was lower in hMSCs. Future investigations will focus on improving gene editing efficiency using different transfection conditions or hybrid methodologies. This study demonstrates the potential of CRISPR/Cas9-based gene therapy in hMSCs as a target for hemophilia B. Further optimizations are required to translate these findings into clinical applications.
The Evolution of Kidney Graft Preservation Through the Years
Authors: Calva Lopez Andres , Robles Garcia Jose Enrique , Yanez Ruiz Carlos Andres , Tapia Tapia Mario Daniel , Talavera Cobo Vanessa , Muñoz Bastidas Carmina Alejandra , Sanchez Zalabardo Daniel , Miñana Lopez Bernardino
Published: December 2024

Chronic kidney disease (CKD) is a prevalent disease affecting almost 10% of the world’s population, with many cases progressing to end-stage kidney disease (ESKD). Kidney transplantation (KT) is the gold-standard treatment for ESKD. Due to growing KT waitlists, the deceased kidney donor (DKDs) criteria have expanded to increase the number of available kidney grafts. Kidney graft preservation ensures optimal graft function after KT. Static cold storage (SCS) as a preservation method is still widely used. Hypothermic machine perfusion (HMP) has proven to decrease delayed graft function (DGF) and increase graft survival. Most recent studies advocate for the use of HMP regardless of donor type. However, emerging technologies, such as hypothermic oxygenated machine perfusion (HOPE) and normothermic machine perfusion (NMP), have shown promising results in specific scenarios. This review aims to provide a summary of the well-established kidney graft preservation methods and their outcomes, as well as novel technological advances that allow for newer preservation strategies.
Therapeutic Impact of Ascorbic Acid on Oral and Periodontal Tissues: A Systematic Literature Review
Authors: Ruzijevaite Gabriele , Acaite Enrika , Jagelaviciene Egle
Published: December 2024

Background and Objectives: Ascorbic acid (AA), a non-metabolized substance in the human body, is acquired from plant-based foods or supplements and is renowned for its antioxidant and anti-inflammatory properties, widely utilized in medicine, particularly in aesthetic practices. In dentistry, exploring adjunctive therapies like AA has gained traction to complement conventional treatments. This systematic literature review aims to assess the effects of ascorbic acid on oral and periodontal health. Materials and Methods: Following PRISMA guidelines, a systematic review was conducted across three electronic databases—PubMed, The Cochrane Library, and ScienceDirect. The review focused on randomized controlled trials and uncontrolled clinical trials published in English between 2018 and 2023, examining ascorbic acid’s impact on oral and periodontal tissues. The search, ending 27 September 2023, identified studies meeting inclusion criteria, assessed using The Cochrane and ROBINS-I bias tools. Results: Seventeen publications, involving 811 patients, met the selection criteria. In the study groups, seven out of nine studies showed better outcomes in indicators such as bleeding on probing, plaque index, gingival index, clinical attachment level, periodontal pocket depth, and/or gingival recession depth (p < 0.05), compared to the control group. Three studies noted reduced VAS scores posttreatment with AA (p < 0.05), while two demonstrated accelerated alveolar healing after tooth extraction. Four publications highlighted ascorbic acid’s efficacy in addressing aesthetic concerns. Conclusions: Ascorbic acid emerges as a potentially effective adjunctive therapy for managing oral and periodontal diseases and improving gum aesthetics.
Occupational Health Risks and HIV Prevention Programming for Informal Extractive Miners in Sub-Saharan Africa: A Narrative Review of Interventions, Challenges, and Lessons Learned
Authors: Dzinamarira Tafadzwa , Moyo Enos , Cuadros Diego F. , Herrera Helena , Mano Oscar , Munyonho Ferris T. , Mhango Malizgani , Musuka Godfrey
Published: December 2024

Introduction: The objective of this narrative review is to examine the health risks associated with informal mining in Sub-Saharan Africa (SSA), with a particular focus on HIV prevention. It aims to review existing interventions targeting this population and identify challenges and opportunities for improvement. Methods: A comprehensive literature review was conducted using databases such as Google Scholar, PubMed, ScienceDirect, and Cochrane Library. Studies and reports published between 2000 and 2023 that focused on occupational health risks and HIV prevention interventions in the informal mining sector of SSA were included in the analysis. Results: Informal mining in SSA presents significant health risks to workers, including exposure to hazardous substances, poor working conditions, and limited access to healthcare. These factors, combined with the high prevalence of HIV/AIDS in the region, make informal miners particularly vulnerable to infection. The review identified several key themes related to occupational health risks, such as poor environmental and sanitation conditions, increased vulnerability due to factors like poverty and lack of education, and limited access to healthcare services. A variety of interventions have been implemented to address HIV prevention among informal miners in SSA. These include behavioral strategies like peer education and social marketing campaigns, as well as biomedical interventions such as counseling, testing, and pre-exposure prophylaxis (PrEP). However, challenges persist in delivering effective HIV prevention services to this population. These challenges include restricted access to healthcare, the high mobility of miners, limited resources, and stigma associated with HIV. Conclusions: The findings of this review highlight the urgent need for integrated health services and tailored interventions that address the specific issues faced by informal miners in SSA. Community-based and culturally sensitive programs, developed in collaboration with mining communities, are essential for effective HIV prevention. Future research should evaluate the long-term impact of interventions and explore their scalability. To improve intervention effectiveness and sustainability, stakeholders should focus on community engagement, strengthening health systems, and addressing structural barriers. A multi-sectoral approach is necessary to tackle the broader determinants of health in mining communities.