bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence of risk factors for diabetes in adult offspring of type 2 diabetes mellitus patients
Authors: Saini Ruchika , Gupta Monica , Jaswal Shivani , Lehl Sarabmeet Singh , Jesrani Gautam , Gupta Samiksha
Published: January 2023

Background:

The risk of developing type 2 diabetes mellitus (T2DM) and associated metabolic abnormalities is higher in adult offspring of patients with T2DM. Various genetic and environmental influences play a facilitatory role. These determinants can lead to the early onset of hyperglycemia, unrecognized end-organ changes, and cardiovascular morbidity.

Objective:

The objective of this study was to identify the presence of undiagnosed diabetes and prediabetes in the otherwise healthy adult offspring of patients with T2DM and to study early metabolic abnormalities among these individuals.

Materials and Methods:

The study population consisted of 100 healthy offspring aged 18 years and above, of parents with T2DM, enrolled from the medicine outpatient area. Anthropometric characteristics, routine investigations and diabetes defining parameters, fasting plasma insulin, and homeostatic model assessment-estimated insulin resistance (HOMA-IR) were assessed.

Results:

The age and body mass index of participants were 32.30 ± 9.33 years and 25.08 ± 4.58 kg/m2, respectively. About 33.3% of males and 76.4% of females had abnormal waist circumference and metabolic syndrome was found in 26% of the offspring. Twenty-eight participants displayed dysglycemia, of which 10 were diagnosed with prediabetes and 18 with diabetes. C-reactive protein, total cholesterol, triglyceride values, apolipoprotein A, B, and their ratio, and HOMA-IR were significantly raised, and high-density lipoprotein was found significantly low in patients with this newly diagnosed T2DM.

Conclusion:

A significant number of asymptomatic offspring of patients with T2DM have incipient diabetes and prediabetes status, which is unidentified. Further, metabolic parameters are more deranged in those with newly diagnosed diabetes and prediabetes. Therefore, opportunistic screening for these offspring should be done routinely.
Introduction to qualitative research methods – Part I
Authors: Bhangu Shagufta , Provost Fabien , Caduff Carlo
Published: January 2023

Qualitative research methods are widely used in the social sciences and the humanities, but they can also complement quantitative approaches used in clinical research. In this article, we discuss the key features and contributions of qualitative research methods.
Attitudes and practices of exercise among pregnant mothers in Singapore
Authors: Tan Yin Ru , Tan Kok Hian , Dai Fei , Tan Hak Koon , Tan Lay Kok
Published: January 2023

Introduction:

There is increasing evidence demonstrating the safety and benefits of physical activity (PA) in uncomplicated pregnancies. Literature has shown that pregnant women around the world do not engage in adequate exercise. This study aims to assess the current practices of exercise among pregnant women in Singapore, determine the proportion of women meeting different PA targets and evaluate the factors influencing the practice of exercise.

Methods:

In this cross-sectional study, pregnant women in different trimesters of pregnancy from KK Women’s and Children’s Hospital and Singapore General Hospital were surveyed. Information regarding patient demographics, attitudes and perceptions of exercise, and practice of exercise was collected. The International Physical Activity Questionnaire (IPAQ) was used to determine the amount of PA.

Results:

A total of 201 pregnant women aged 20–44 years were surveyed. Almost all (99.0%) participants thought that exercise was beneficial in pregnancy. Only 31.6% of them engaged in any moderate or vigorous leisure-time PA (LTPA) and they were active for a median of 120 min/week. Only 12.6% of the pregnant women met the national recommendations of at least 150 min of moderate exercise per week. The amount of total PA performed was lower among women in later trimesters of pregnancy and higher among working mothers.

Conclusion:

Although most Singaporean pregnant women perceived exercise as beneficial, the majority did not engage in PA. Most of the participants did not meet the international PA targets and recently published national guidelines. More can be done to promote the uptake of exercise in pregnancy and optimise metabolic management of pregnant women in Singapore.
Variational Hodge conjecture for complete intersections on hypersurfaces in projective space
Authors: Kloosterman Remke
Published: January 2023

In this paper, we give a new and simplified proof of the variational Hodge conjecture for complete intersection cycles on a hypersurface in projective space.
Biodefluorination of Perfluorooctanesulphonate by Ensifer adhaerens M1
Authors: Danil Sharipov , Sergey Starikov , Sergey Chetverikov
Published: January 2023

A strain of bacteria M1, defluorinating perfluorooctanesulfonic acid (PFOS), was isolated from soil taken from the territory for testing fire extinguishing agents. The analysis of cultural, morphological, physiological and biochemical characters, the 16S rRNA gene sequencing allowed us to identify strain M1 as Ensifer adhaerens. The uniquely skill of the isolated strain to utilize PFOS in a mineral liquid medium for 5 days of cultivation was shown. It was found that E. adhaerens M1 transforms perfluorooctanesulfonic acid into perfluoroheptanoic acid, releasing 152 mg/L of free fluoride ions from 1,000 mg/L of PFOS. The data obtained allow us to recommend E. adhaerens M1 as potential treatment agent of the environment from organofluorine compounds.
A Meta-Analysis of Latex Physiology Studies Reveals Limited Adoption and Difficulties to Interpret Some Latex Diagnosis Parameters in Hevea brasiliensis
Authors: Junaidi Junaidi , Clément-Vidal Anne , Nuringtyas Tri Rini , Gohet Eric , Subandiyah Siti , Montoro Pascal
Published: January 2023

Latex diagnosis is widely adopted in natural rubber-producing countries to optimize the natural rubber production through a physiological-based latex-harvesting system management. This study is the first bibliographical searching and meta-analysis on the variation of latex physiological parameters i.e. sucrose, inorganic phosphorus, thiols, and total solid content. The study used information extracted from 158 scientific papers. Descriptive statistics, agglomerative hierarchical clustering, and principal component analysis were performed to characterize applications of latex diagnosis, how often parameters are used and interpreted as well as the variation of its parameter values. From 158 papers, latex diagnosis parameters were used in 114 agronomy, 22 in physiology, and 22 in breeding papers. The agglomerative hierarchical clustering analysis indicated that sucrose and inorganic phosphorus contents were clustered together and total solid and thiols contents were located in another cluster. The average values of the total solid content, sucrose, inorganic phosphorus and thiols were 43.9%, 9.4 mM, 16.5 mM, and 0.52 mM, respectively. The percentage of interpretation is 63.3% for sucrose, 54.4% for inorganic phosphorus, 47.5% for thiols, and 41.1% for the total solid content. The low interpretation of thiols and total solid contents question their relevance in latex diagnosis. The low adoption of latex diagnosis in breeding could hinder the selection of activities leads to a limitation of selection for long-term high yielding and stress-adapted clones.
SOCIAL COMPETENCE AND AFFECTIVE STYLES OF EMOTION REGULATION AMONG UNIVERSITY STUDENTS
Authors: Khan Dr. Mussarat Jabeen , Gulmeena Tahir  , Ajmal Dr Fouzia
Published: January 2023

Being social animals human being always strive to interact with others, which needs social competence. However they need to manage their emotions also. This particular research was carried out to find the relationship between social competence and different affective styles of emotion regulation of university students. Moreover the gender difference on social competence and affective styles of emotion regulation was also checked. Correlation research design was used and data were collected through survey technique from male and female students of Foundation University, COMSATS University, Quaid-i-Azam University, Capital University and International Islamic University. Social Competence Scale and Affective Style Questionnaire were administered on university students for data collection which were analysed using mean, Standard Deviation, t-Test and pearson correlation. A significant correlation between social competence and affective styles of emotional regulation (adjusting, tolerating and concealing styles) was found. It was also observed that gender difference between university students on social competence was significant. However gender difference on emotional regulation was non-significant. Using positive affective styles of emotional regulation can help to reduce stress, tension, anxiety and depression among university students.
The Correlation Between Knowledge of Family Development Tasks and the Application of Developmental Stimulation in Pre-School Aged Children
Authors: Tressia Tressia Febrianti , Nursasi Astuti Yuni , Fitriyani Poppy
Published: January 2023

The development of a child is a fundamental part of human development; this emphasizes the architecture of a person's brain formed at the beginning of life, which comes from genetic and environmental influences. There are two important factors that influence a child's development, namely genetic factor and environmental stimulation factor. Stimulation has an important role in the growth and development of children because the child's brain develops very quickly when it is stimulated. The main task of a family that determines the child's ability is on the task of family in every stage of family development. This study aims to determine the correlation between knowledge of family development tasks and the application of developmental stimulation in preschool-aged children. The research design used was quantitative research with a correlational descriptive method and a cross sectional study approach. The data obtained from 242 respondens and then analyzed using bivariate analysis (chi-square test). After analyzing the data, the results showed that the value of p=0.000 (<α 0.05). Hence, there is a significant correlation between knowledge of family development tasks and the application of developmental stimulation in pre-school-aged children. Families who have good knowledge of family development tasks have the ability to perform developmental stimulation 22.6 times greater than families who have less knowledge. Family knowledge about good family development tasks will have an impact on meeting children's needs. The children who get good stimulation could have a better impact on their development. The result of this study is expected to be the basis for Community Nurses who work in primary health services to be able to carry out promotive and preventive efforts with a family approach.
Bazı Fasulye (Phaseolus vulgaris L.) Genotiplerinin Ozmotik Strese Tepkisi
Authors: UYGUR GÖÇER Emine , AYDIN Adnan
Published: January 2023

Fasulye (Phaseolus vulgaris L.) gıda üzerine birçok alanda kullanılır, ancak kurak ve tuzlu şartlara son derece hassastır. Kuraklık ve tuzluluk kültürü yapılan bitkilerin gelişimini ve üründen alınan verimi etkileyen önemli çevresel faktördür. Bu çalışma da amaçlanan fasulye genotiplerinde farklı tuz konsantrasyonları ve kuraklık dozunun tohum çimlenmesi, büyüme parametreleri üzerine etkilerini araştırmaktır. Çalışmada tuz olarak kontrol, 100 mM, 200 mM dozları NaCl uygulanırken kuraklık olarak %15 PEG 6000 uygulanmıştır. Tesadüf parselleri deneme desenine göre üç tekrarlamalı olarak kurulan bu araştırmada NaCl dozlarına göre çimlenme oranı %20-100, Radikula ağırlığı, 0.024-0.486 g, plumula ağırlıkları 0.061- 0.611 g, radikula uzunlukları 0.663-5.100 cm arasında değişmektedir. %15 PEG uygulamasına göre ise çimlenme oranı %20-100 arasında radikula ağırlıkları 0.007-0.276 g, plumula ağırlıkları 0.012 -0.125 g ve radikula uzunlukları 1.523–5.162 cm arasında değişmiştir. Çalışma sonucunda PN055 genotipinin çalışmada kullanılan diğer genotiplere göre tuzluluk ve kuraklığa daha dayanıklı olduğu tespit edilmiştir.
Öğrenci Ebelerin Doğum Sürecinde “Saygılı Annelik Bakımına” İlişkin Görüşleri: Nitel Bir Araştırma
Authors: AKTAŞ REYHAN Feyza , DAĞLI Elif
Published: January 2023

Amaç: Saygılı annelik bakımı, Dünya Sağlık Örgütü tarafından tüm kadınlar için önerilen ve kadınların onurunu, mahremiyetini koruyan, zarar ve kötü muameleden uzak durmayı sağlayan ve bilinçli seçim ve doğum sürecinde sürekli destek sağlayan bakım anlamına gelmektedir. Bu konuda farkındalık sağlamak adına ilk adımı attığımız bu çalışma ile amacımız, öğrenci ebelerin doğum sürecinde “saygılı annelik bakımına” ilişkin görüşlerini belirlemektir. Örneklem ve Yöntem: Araştırma niteliksel olarak Şubat 2022 tarihinde bir devlet üniversitesinin Ebelik Bölümü öğrencileri ile yapılmıştır. Örneklem sayısı, amaçlı örneklem türlerinden ölçüte dayanaklı örneklem ile saptanmış olup 15 öğrencide doygunluk noktasına ulaşılmıştır. Veriler araştırmacılar tarafından hazırlanan soru formu ile derinlemesine görüşmeler yapılarak toplanmıştır. Verilerin analizinde içerik analizi yöntemi kullanılmıştır. Bulgular: Araştırmaya katılan öğrencilerin doğum sürecinde saygılı annelik bakımı konusundaki görüşleri “Saygılı annelik bakımını tanımlama”, “Saygılı annelik bakımı bileşenleri” ve “Saygılı annelik bakımının önemi” olmak üzere üç tema altında toplanmıştır. Saygılı annelik bakımı bileşenleri teması altında literatürle paralel olarak, “Kötü muameleden kaçınma, ayrımcılık yapmama, etkili iletişim kurma, sosyal desteğe erişim sağlanması, bilgilendirilmiş onam alınması, kadının doğurabilme gücünü destekleme, Sürekli ebelik bakımı sağlama” alt temaları toplanmıştır. Sonuç: Bu çalışmada ebe öğrencilerin doğum sürecinde kadınlara saygılı annelik bakımı konusunda mahremiyeti sağlama, etkili iletişim kurma, kötü muameleden uzak durma, nitelikli bir ebelik bakımı sunma gibi faktörlerin öneminin farkında oldukları ve çalışma hayatlarında birçok şey yapabilecekleri görüşünde oldukları sonucuna varılmıştır.
The Relationship of Personality Traits on Pregnant Women on Stress and Adaptation to Pregnancy
Authors: DAĞLAR Özge Şiir , OSKAY Ümran
Published: January 2023

Aim: This study examined the relationship of personality traits on pregnant women on stress and adaptation to pregnancy. Subject and Method: The study is of descriptive type and the sample of the study consisted of 250 pregnant women who applied to the obstetrics clinic of a state hospital. Data were collected using the Introductory Information Form, Cervantes Personality Scale (CPS), Prenatal Distress Scale (PDS), and Prenatal Self-Evaluation Scale (PSES). The data were evaluated with descriptive statistics, 't-test' and 'pearson correlation analysis' in the SPSS program. Results: It was found that the mean age of the pregnant women was 28.65±5.22 and the mean gestational week was 32.94±5.18, 68.4% of them were at least secondary school graduates and 82.4% of them did not work in any job. It was found that pregnant women were more introverted and emotionally stable, answered questions consistently, had low prenatal distress levels, and showed good pregnancy adjustment. A significant relationship was found between the PDS and PSES (p<0,001). Moreover, a significant relationship was also present between the sub-dimensions of emotional balance/neuroticism and consistency/inconsistency, and PDS and PSES scores (p<0,001). Conclusion: It was observed that as the stress level of pregnant women increased, their adaptation to pregnancy decreased, especially women with neurotic personality traits had higher prenatal distress levels and lower adaptation to pregnancy. It can be suggested that all health professionals serving pregnant women should consider the basic personality traits of women in their attempts to reduce prenatal stress and increase compliance with pregnancy.
INDOLE ACETIC ACID (IAA) PRODUCTION POTENTIAL OF PGPR BACTERIAL ISOLATES AND THEIR EFFECT ON SEED GERMINATION IN ZEA MAYS L.
Authors: Yılmaz Semih , Ünlü Emel , Mamoori Khalid , Çetin Aysun
Published: January 2023

The study was conducted to determine the presence of indole-3-acetic acid (IAA) in PGPR isolates using PCR reactions and biochemical tests. Positive isolates were tested under in-vitro conditions for germination efficiency on maize (Zea mays L.) seeds. Salkowski method was used for IAA tests on 30 bacterial isolates with PGPR properties. The KH14.3 and KH24.1.2 isolates were biochemically active in terms of IAA test. The absorbance readings were made at 595 nm using microplate reader and resultant values were compared to an IAA standard. IAA production of isolates varied between 0.42-6.37 μg/ml. For germination experiments, 20 maize seeds were coated with IAA- positive isolates (1.3x107 cfu/ml) in petri dishes in triplicates according to the randomized plot design. The germination test was monitored for 7 days in an incubator at 25°C. Experimental data were subjected to analysis of variance (one-way ANOVA). The difference between the bacterial coating and control group was significant at the level of P≤0.05. Germination efficiency was determined as 99.9% for KH14.3 and 2.7% for KH24.1.2. Present findings revealed that KH14.3 was ACC deaminase, phosphatase, and siderophore-positive and KH24.1.2 was positive for ACC deaminase and phosphatase. These two isolates were also biochemically active in terms of IAA and could increase germination success by coating on seeds.
DETERMINATION OF THE GENETIC SIMILARITIES/DIFFERENCES OF SOME ANNUAL GRASS VARIETIES
Authors: Kaplan Mahmut , Kilinç Nadide , Pinar Hasan
Published: January 2023

This study was conducted to determine the genetic similarities/differences of twenty-five annual grass varieties using the SRAP marker system. While the mean polymorphism rate was determined as 87%, the highest polymorphism was determined in the Me4 Em6, Me4 Em7, Me2 Em13, Me4 Em4, Me4 Em9, Me4 Em11, Me4 Em12, Me2 Em14 and Me3 Em2 primer combinations. The lowest polymorphism rate was obtained from Me3 Em3 (70%) primer combination. According to the dendrogram obtained from the molecular characterization of grass varieties using SRAP molecular markers, great variation was observed between the genotypes. The degree of similarity in the dendrogram varied between 0.54-0.90. According to the findings, it can be said that the SRAP marker system was an effective marker system in determining the genetic similarities and differences between different grass varieties. In addition, the variation obtained among the annual grass varieties used in the study can be used both in the grass application and in breeding programs.
Performance Comparison of Covariance Function to Interpolate Unsampled Points with Simulation Data in Manado City
Authors: Soleman Claudya , Weku Winsy , Salaki Deiby
Published: January 2023

The covariance function measures the strength of statistical correlation as a function of distance. This follows Tobler's law which states that everything is usually related to all else but those which are near to each other are more related when compared to those that are further away. The correct weight of the basic covariance structure will produce the optimal kriging predictor. One interesting way to evaluate the strength of a kriging interpolation is to perform a simulation using a spatial structure. The simulation technique is executed in Manado City. The data is then applied to the variogram model using the spherical and matern covariance functions. The type of kriging method used in this simulation is ordinary kriging. The result shows that the suitable model to use is the matern model. Residual results from cross-validation show that the matern model has a lower biased estimation on both data. According to the RMSE and MAE criteria, the matern model outperforms the spherical model on data A and data B. The results of the interpolation are then visualized in the form of a map. Through this research, it can be concluded that the accuracy of the selection of the covariance function in the variogram model will provide a good estimate for the kriging method, and the most appropriate model for this case is the matern model.
Mean-Variance Investment Portfolio Optimization Model Without Risk-Free Assets in Jii70 Share
Authors: Gusliana Shindi Adha , Salih Yasir
Published: January 2023

In investing, investors will try to limit all the risks in managing their investments. Investor strategies to minimize investment risk are diversification by forming investment portfolios, one of which is the Mean-Variance without risk-free assets. The calculation results will show the composition of the optimum portfolio return for each stock that forms the portfolio. Optimum portfolio obtained with wT = (0.39853, 0.25519, 0.13644, 0.09788, 0.11196) sequential weight composition for TLKM, KLBF, INCO, HRUM, and FILM stocks. The composition of this optimal portfolio return is ðœ 0.04 with a return of 0.00209 and a portfolio variance of 0.00015. The formation of this portfolio optimization model is expected to be additional literature in optimizing the investment portfolio with the Mean-Variance.
Social Distancing, Vaccination and Evolution of Covid-19: A Panel-Model Analysis
Authors: Campos Eduardo Lima , Cysne Rubens Penha , Madureira Alexandre
Published: January 2023

Abstract

This work discusses the impact of social distancing and vaccination on the monthly variation rate of new cases and deaths of COVID-19 around the world. A statistical panel-regression model was applied to daily data for 131 countries from March, 2020 to December, 2021. The setting of suitable control variables was essential to achieve reliable results. We found, as a possible consequence of strict social distancing, a decrease of around 5.5 percentage points in the growth rate of both new cases and deaths, before vaccination. The possible impact of progress in vaccination, in 2021 was even stronger: a decrease of 9 and 12 percentage points on the growth of new cases and deaths, respectively. As a final conclusion, our dataset and the method employed did not allow to exclude either the hypothesis that strict social distancing was an important measure to control the pandemic before the advent of vaccines, nor the conjuncture that the impact of vaccination has been stronger, mainly with regard to deaths.

JEL classification numbers: C13, C33, I18.
Keywords: COVID-19, Social Distancing, Vaccination, Panel model.
Neuroscience as a Component in Educational Setting. An Interpretive Overview
Authors: Farmakopoulou Ignatia , Theodoratou Maria , Gkintoni Evgenia
Published: January 2023

In recent years, considerable advancements have been made in the field of educational neuroscience research. Researchers commend its existence and influence on educational procedures. This effort was intended to illustrate the educational applications of Neuroscience. In particular, research articles, quantitative and qualitative analyses, meta-analyses, and articles of critical inquiry on Neuroscience in Education were examined. In addition, a review of recent literature was attempted. From these studies, conclusions can be derived that can prove useful in the fields of research and teaching. Thus, best practices, methodologies, perspectives, attitudes, and perceptions that support the significance and value of Neuroscience in the field of education are offered.
Life adaptation with polycystic ovary syndrome: physiological and psychological
Authors: M. Mousa Nuha , Abdul Munem Hawraa. A. , Dakl Adian A.
Published: January 2023

One of the main causes of infertility is a polycystic ovarian syndrome (PCOS), a persistent female endocrine disorder with characteristics that adversely impair appearances, physical health, and intellectual well-being. Infertility and psychological stress have a complicated link. Up until now, a rise in infertility has been linked to high levels of psychological suffering. So, one of the main reasons for excessive stress in couples attempting to consider is psychological stress, which contributes to infertility. PCOS symptoms include IR, hyperinsulinemia, poor glucose tolerance, and cardiovascular diseases may be caused by physiological changes. These indications and symptoms are further complicated by factors like insulin resistance (IR), dyslipidemia, endothelial damage, and systemic infection, which increase patients’ risk of cardiovascular disease compared to women without PCOS. This review focus on the relationship between physiological modification and metabolic outline of PCOS patients, as well as its associations for their infertility and PCOS, identifying some vulnerability signs as well.
Antibacterial activity of fungal extracts against bacterial isolates from tonsillitis in children
Authors: Ahmad Zayden Mariam , Khalaf Saleh Mahmood
Published: January 2023

One hundred samples were collected from children tonsillitis, (1-12) years, in Al-Shirqat General Hospital through the period from October to November 2018.Isolated was divided into two parts according to gram stain (Positive and Negative bacteria). 77 isolates (85.5%) were gram positive and 13 isolates (14.5%) was gram negative bacteria. The sensitivity of the isolates was tested for some antibiotics, and the negative bacteria for the gram stain showed high resistance to the antibiotics compared to the positive bacteria for the gram stain. The inhibitory activity of ahcoholic and aqueous for truffle Terfezia sp. and Gonoderma lucidum was four different concentrations (25%, 50%, 75%, 100%) mg / ml. The results showed that the aqueous extracts against some isolates was inhibition zone diameters between (8-25) mm. While the results of alcoholic truffle extract were not showed any activity against isolates. Also the results of the aqueous extract of the Gonoderma lucidum showed the inhibitory activity of some isolates with inhibition zone between (7-30) mm. As for the alcoholic extract of the mushroom, it was not showed any inhibition activity against the bacterial isolates.
Molecular docking of putative phytochemicals in aqueous Moringa oleifera leaf extracts with three cytochrome P450 enzyme involved in xenobiotic metabolism
Authors: Sarkar Diptendu
Published: January 2023

The Indian plant Moringa oleifera is found in tropical and subtropical climates across the globe. It is frequently cultivated for its embryonic seed pods and leaves, that are consumed as vegetables and also for herbal remedies. Using in silico computational techniques and three CYP450 enzymes, this study assessed the potential hepatoprotective effects of probable metabolites in watery M. oleifera leaf extracts. All quantities of aqueous M. oleifera leaf extract were subjected to several qualitative phytochemical analyses. The flavonoid galangin demonstrated the strongest interactions with the majority of cytochrome P450 enzymes in accordance with the predicted binding affinity, followed by caffeic acid. Galangin also outperformed the bulk of other known CYP450 enzyme inhibitors. These results suggest that the hepatoprotective effects of M. oleifera leaf extract on CYP450 may be due to galangin. In comparison to galangin and caffeine acid, two reference substances, 1H-indazole, and alpha-naphthoflavone, were shown to have energy values with all three receptors between -4.6 and -4.8. The in silico screening data showed that when docked to CYP1A2, CYP2E1, and CYP2D6, all compounds had a greater binding affinity. Therefore, additional studies are necessary to support these findings.
Investigating the ability of bacteria isolated from various artificial respiratory systems to resist antibiotics and biofilms formation
Authors: Mohammad Khadija Ismail , Hussein Taha Alaa
Published: January 2023

Respiratory infections associated with ventilators represent a significant risk to individuals in intensive care units, particularly children under 3 years of age. 100 sample were collected Between October 2021 and February 2022, from Mosul hospitals (Ibn Al-Atheer Teaching Hospital, Ibn Sina Teaching Hospital, Al-Salam Hospital, and Al-Khansa Teaching Hospital) at ages 1 day to 3 years. A swab was taken from the water chamber of the artificial breathing devices, and the catheter head was collected, where the mucous material was cultured in three different mediums (blood agar, MacConkey agar, and Chocolate agar). 80 bacterial isolates were collected. The highest percentage was determined to be connected to Gr- bacteria, with 65 isolates 81.25%, and 15 isolates 18.75% being Gr+ bacteria. Using the Kirby-Bauer disc diffusion method, it was discovered that all isolates had great resistance to the antagonist’s ampicillin and ceftriaxone, but high sensitivity to both Imipenem and Meropenem. The tube method was found to be more efficient than the Congo red agar method in the detection of biofilms. Klebsiella pneumoniae, Stenotrophomonas maltophilia, Burkholderia cepacia group, and Pseudomonas mendocina were biofilm-forming in both ways by up to 100%. The current investigation found that the tube approach produced 100% biofilm, but the Congo red agar method produced 41.25% biofilm.
Involvement of gastrointestinal tract associated microbiota in direct and indirect immunomodulation: An overview
Authors: Sarkar Diptendu , Mitra Souvik
Published: January 2023

Gastrointestinal Tract (GIT) associated microbiota is a diverse community of trillions of microorganisms, which homeostatically co-exist with the host in normal conditions and interact actively with the physiological processes of the host. Among them, some microorganisms impart beneficial effects on the host while pathogens and opportunistic pathogens always tend to invade host body cells. Many studies have now established that probiotic bacterial strains can modulate our overall immunity and play crucial roles in digestion, metabolism, brain-gut communication, etc. Talk about immunomodulation by probiotics, studies have revealed that many bacterial strains regulate innate and adaptive immunity either directly engaging immune cells of the host body or indirectly by blocking the entry of pathogens and viruses into the host body. In this overview, we will talk about how probiotics affect immunity by promoting the creation of tight junctions (TJs), raising mucin secretion, and improving the cytotoxicity of macrophages and Natural Killer (NK) cells. The discussion will give us a holistic idea about immunomodulation by gut microbiota (GM) and provide an opportunity to use the information for human welfare.
Risk factors of cancer: a review
Authors: H. A. Emaduldeen , J. Shamran Dhifaf , J. Mahdi Dhuha , Muayad T.A. Mohammed
Published: January 2023

Cancer has been known since BC., with rare incidence. At that time, some scientists tried to treat cancer, and some tried to find out the reason(s) behind the occurrence of cancer, and they put up many hypotheses. Nowadays, with all progression in medical technology and diagnostic methods, the causes of cancer remain unclear. But the causes of cancer can be an interaction between a person’s genetic factors and external carcinogens factors that can be divided into physical, chemical, and biological carcinogens. In this review, the risk factors of cancer were discussed.
Finding antagonist for the VP24 protein of the Ebola virus to treat infections using molecular docking and molecular dynamics studies
Authors: Sarkar Diptendu , Ahamed Sk Murtaj
Published: January 2023

Among all known viruses, Ebola has the unfortunate distinction of having some of the highest case-fatality rates. It is critical that new antivirals be developed to fight Ebola virus infections. A simulated screening of nearly 20 compounds against the revised protein structure of Ebola as represented by the GP24 model resulted in the selection of one molecule (CID 3851453) that may one day be used as an antiviral drug for the Ebola virus. It was found that binding energy was -7.4 Kcal/mol. The physiological and bioactivity parameters were correctly predicted together with ADMET. The 50 ns molecular dynamics simulation results’ RMSD, RMSF, and Rg values showed that the proposed compound was well equilibrated and, as a result, stable in the protein-ligand complex. The substantial binding affinities of this chemical (CID 3851453) to the receptor cavity were consistent with the findings of the docking studies. Additionally, it is expected that the identified inhibitor (CID 3851453) will serve as a more advantageous starting point for future experimental studies in the hunt for antiviral medications.
Inhibitory effect of aqueous extract of flowers Dianthus chinensis on the proteins and acetycholinesteras for Bothriocephalus acheilognathi
Authors: Kanaan Ali Raya , AL-Kallak Sundus Natheer
Published: January 2023

Livestock plays a significant role in the national economy, making it crucial to safeguard the livestock population in order to achieve economic growth and increase exports. The current study aimed to determine whether or not the addition of an aqueous extract of Chinese carnation flowers to the tissues of the parasitic worm Bothriocephalus acheilognathi found in carp fish affected their total protein content and the enzyme’s activity (Cyprinus carpio). Treatment with an aqueous extract of Chinese carnation flowers was found to raise both total routine concentration and acetylcholinesterase activity (AchE). The parasite’s demise is ultimately caused by the host’s behavior, reproduction, health, and other factors.
Статистический анализ методов лечения больных, госпитализированных с кишечной непроходимостью в «Городскую клиническую больницу №7» г. Алматы в период 2015-2021 гг.
Authors: Досжанов Нариман , Насырова Наргиза , Болтириков Керим , Серкебаева Жанерке , Садыкова Наргыз , Жетписбай Марлен , Жузтай Нурай , Ескермес Акерке , Андасова Жулдыз
Published: January 2023

Цель: провести исследования статистического анализа методов лечения больных, госпитализированных с кишечной непроходимостью в «Городской клинической больнице №7» г. Алматы в период 2015-2021 гг.    Материалы и методы: нами был проведен ретроспективный анализ 161 016 поступивших больных, в отделение «Хирургия-1» ГКБ №7 г. Алматы, методом сплошной выборки в возрастном диапазоне от 21 до 90 лет. Исследование проводилось как сравнительный статистический анализ в период с 2015 по 2021 года. Результаты: в результате исследования мы выявили, что период пандемии 2020 году был максимальный рост спаечной непроходимости кишечника и видим прогрессивный рост кишечной непроходимости в целом. По возрастной категории более подвержены к данному заболеванию пациенты от 35 до 60 лет. Выводы: по проведенному результату исследования от общего числа пациентов, приходим к выводу что в период пандемии за 2020 год был максимальный рост заболеваемости за последние 6 лет. Заболеваемость все чаще происходит у лиц молодого возраста.
“Bioactive Dental Composites And Bonding Agents”
Authors: Abdulmageed Alhusainy
Published: January 2023

Existing dental restorative materials are largely inert and used to restore lost tooth components. In this article, we will look back at the progress that has been made on a new class of bioactive materials that can not only restore the loss of tooth structure but also serve as therapeutic agents. Replacement of lost minerals, inhibition of recurrent caries, neutralization of acids, repulsion of proteins, suppression of biofilms and acid production, demonstration of low cytotoxicity similar to current resins, protection of dental pulp, and promotion of tertiary dentin formation are all possible with remineralizing and antibacterial composites and bonding agents. The ability to ion release and prevent caries is a promising use for this emerging class of bioactive materials.
PROCESSO DE CONSTRUÇÃO DE REFERENCIAL TEÓRICO VIA EXTRAÇÃO DE DADOS DA PLATAFORMA SCOPUS E INDICADORES DE PRODUÇÃO
Authors: Melo de Souza Edson , Pessarelo Smulkowski Souza Gustavo
Published: January 2023

Contexto: A pesquisa e elaboração de referencial teórico de relevância em produções científicas é um processo árduo e demorado para o autor iniciante ou com pouca experiência. Objetivo: Este artigo apresenta um processo de pesquisa bibliográfica para a construção inicial do referencial teórico com o uso da Tecnologia da Informação (TI) para acesso, recuperação e gerenciamento da bibliografia. Materiais e métodos: Os experimentos executados empregaram metodologias qualitativas e indutivas, visando a realização de pesquisas online na base de periódicos eletrônicos Scopus, por meio de buscas por palavras-chave e parâmetros de filtragem. Para selecionar as melhores referências, foram utilizados o índice “h” e a classificação dos periódicos pelo Qualis-CAPES. Além disso, o programa gerenciador de referências Mendeley foi a ferramenta de TI usada para o gerenciamento da bibliografia. Resultados: As estratégias de pesquisa propostas para a seleção de palavras-chave, em conjunto com a análise da qualidade das publicações, forneceram condições para reduzir de 18.087 para 22 artigos, totalizando 2.263 citações relevantes para a construção do referencial teórico. O programa Mendeley permitiu a organização e exploração de detalhes dos artigos com facilidade e praticidade. Conclusão: Por fim, infere-se que as estratégias de pesquisa utilizadas em conjunto com a metodologia proposta e com a ferramenta de TI selecionada mostraram-se eficientes como suporte ao processo de busca, recuperação e catalogação de artigos científicos para a elaboração de referencial teórico relevante.
TECHNOLOGICAL ACCELERATION AND THE ROLE OF ART IN PREDICTING THE AFTERMATH OF SINGULARITY
Authors: ALI HUSSEIN Mohammed , Suhail ATIYAH Azhar
Published: January 2023

The technological advance of the last decades leads us to imagine a future where technological systems and artificial intelligence (AI) physically and intellectually surpass human intelligence (IH) reaching, in fact, to be able to improve itself without the need for human intervention. From the possibility of the emergence of Cyborgs, Post Humans, and the arrival of what experts have called Technological Singularity, we must allow ourselves to reflect on these concepts in order analyse the possible effects, the results that this rapid technological advance could lead us to, and the possible consequences that a hard superintelligence would bring with it. The study tries to probe the scope of Singularity and its fundamental aspect, the alteration of the technological ecology: the strong pace of innovation would continuously transform the world and the human being itself, making the forecasting effort extremely difficult. It presents definitions of singularity according to its main figures: Von Neumann, I. J. Good, Vernor Vinge, and Ray Kurzweil. It revolves around the idea that the technological acceleration will continue to state that humanity couldn’t control. In this case AI will surpass the human abilities. It also unfolds the role of art in predicting the aftermaths of Singularity. Since the scientists are not sure about the result after Singularity, the role of imagination becomes the proper tool for exploring the technologized future. Key words: Singularity, Technological Acceleration, Science Fiction, Vernor Vinge, and Ray Kurzweil
A STUDY ENTITLED THE EXTENT TO WHICH RIYADH TEACHERS HAVE THE ABILITY TO REDUCE BULLYING BEHAVIOR OF SOME KINDERGARTEN CHILDREN IN AL-MARJ CITY
Authors: Bashir ALI Ibtisam
Published: January 2023

Childhood is considered one of the distinguished periods in human life, and scholars have stressed the importance of giving it special care and providing advice, instructions, examples and good models, as good upbringing arises. Followed by the nanny in disciplining children who suffer from bullying, and to achieve the goal of the study, a questionnaire prepared by (Shorouk Abdul Aziz 2020) was used, and it was applied to the nannies of Riyadh in the city of Al-Marj) Percentages, arithmetic mean, and standard deviation were used in data processing. The results showed that the low economic level, lack of self-confidence, neglect, as well as watching electronic games are all causes of bullying. Bullying and its negative aspects and cooperation with parents in raising awareness of those who have aversion and their danger to themselves. Key words: Teacher; Physical Education; Habits of Mind; Multiple Intelligences
Assessment Genetic Variability among Three Parents and Six Progenies of Tomato using Multivariate Analysis
Authors: Osekita Oluwatoyin Sunday
Published: January 2023

Six tomato hybrids developed through diallel mating design and the three parents were obtained from the plant breeding section of Adekunle Ajasin University Akungba-Akoko and used to assess the genetic variability among them. The breeding materials were raised in the nursery for three weeks before transplanting. The hybrids and parents were laid out in a randomized complete block design (RCBD) replicated three times Seedlings were transplanted at a spacing of 60 x 30 cm between and within row. Variability estimates were highly significant (p< 5%) in all the 10 measured quantitative traits. The average fruit mean yield of 21.42 g was recorded for all the materials evaluated. Phenotypic variances were higher in magnitude than its corresponding genotypic variances apart from pericarp thickness which had the same value of 0.002 and 100% heritability. Factor scores and communality of the 10 traits of tomato obtained from the factor analysis showed that the first factor were positively loaded with eigen vectors for number of branches (0.818), number of fruits per cluster (0.803), plant height (0.776), fruit yield (0.748) and number of clusters per plant (0.731). The second factor was positively loaded with pericarp thickness (0.723) and number of clusters per plant (0.460). Factor three was only positively loaded with fruit weight (0.881). The communality ranged from 0.618 for fruit yield to 0.930 for fruit weight. Conclusively, traits such as fruit yield, pericarp thickness, fruit weight, number of locules per fruit, days to flowering and days to first fruit set are important traits that should be considered in further breeding programme in tomato.
Autoimmune limbic encephalitis combined with leptomeningeal metastases of non-small cell lung cancer: treatment response to osimertinib, immunoglobulin, rituximab, and tocilizumab
Authors: Lee Seolah , Ahn Seon-Jae , Lee Han Sang , Chu Kon
Published: January 2023

When a patient with encephalopathy has an organic brain lesion, his symptom is easily and often mistakenly attributed to that brain lesion. However, a combination of different conditions is also possible. We present a case of autoimmune limbic encephalitis combined with leptomeningeal carcinomatosis. A 57-year-old female patient was transferred to our institute with a 1-month history of seizure and aggressive behavior. Subacute onset of psychosis with multifocal T2 high signal lesions suggested autoimmune encephalitis, and high-dose steroid pulse and immunoglobulin therapy were started. However, a cerebrospinal fluid study revealed metastatic adenocarcinoma of non-small cell lung cancer, of which she was in complete remission state. Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, was started targeting leptomeningeal metastases while maintaining immunotherapy of rituximab and tocilizumab. Her neurological symptoms showed improvement in response to immunotherapy which lasted approximately 1 month and then deteriorated again. We concluded that her symptoms were more attributable to autoimmune encephalitis than leptomeningeal carcinomatosis, and discontinued osimertinib.
Factors Influencing Buying Behaviour of Ayurvedic Products - A Review
Authors: Bharathi  , Mayya Suresh Ramana
Published: January 2023

Purpose: Ayurveda, a system of conventional medicine with roots in ancient wisdom, has grown in importance in modern society and today plays a significant role in every aspect of human existence. Ayurveda gained notoriety due to its purity, safety, naturalness, and lack of adverse effects. The main objective of this study is to identify the various factors that influence how consumers buy ayurvedic products, how these factors foster consumer trust, how consumer trust is transformed into purchase intention, and finally, how consumer purchase intention is transformed into final consumer behaviour.
Design/Methodology/Approach: Secondary sources are used to gather the information needed for the current investigation. This is based on an analysis of the literature that has already been published, including information from a variety of exploratory articles, papers, books, journals, and magazines. The information needed for the study was gathered via Google Scholars, Research Gate, and Science Direct.
Results/ Findings: Consumer purchasing behaviour is influenced by a variety of factors. Manufacturers of ayurvedic products must take into account the different aspects that affect consumers' decisions to buy herbal products. The corporations can alter the things they are producing based on the analysis of these elements, making it simpler for marketers to promote their goods.
Originality/Value: Through this review, the various factors influencing the buying habits of consumers who use ayurvedic products and other areas of the body of existing literature help manufacturers and marketers comprehend the influencing factors on the buying habits of customers of ayurvedic products so they can create their own marketing strategy to popularise the ayurvedic products, thereby increasing sales and profit.
Type of Paper: Review of Literature
"PHONETIC PECULIARITIES OF THE DEFENCE SPEECH OF A LAWYER "
Authors: G. T. Kussepova  , К. S. Kenzhigozhina  , B. K. Zhumabekova
Published: January 2023

"The article aims to uncover the phonetic peculiarities of an attorney’s defence speech in the English and Kazakh languages from the perspective of persuasive speech technique. The reason for analysing the phonetical peculiarities of an attorney’s defence speech is that the responsibilities of an attorney comprise the litigation of the client from the beginning to the end of the case; in particular, working with the client, revealing evidence and witnesses; identifying, selecting, and collecting paperwork; talking with the client to formulate the exhibits; clarifying the issue through questions and answers, and the last step is defending in court. These activities require an attorney to be well acquainted with legal literature and the language of the court, which precisely, takes place in the courtroom. Thus, we have collected the fragments of attorney defence speech that took place at the trial from the YouTube channel and analysed the phonetic features using the Praat computer program. The authors demonstrate how phonetic features are realised during cross-questioning moments using excerpts from an attorney’s persuasive speech. These findings shed light on how the persuasive speech of the attorney can create the discursive space and phonological features of the speech to effectively impact the process. "
THE PECULIARITIES OF METATEXT ELEMENTS IN PUBLIC SPEAKING «TED Talks»
Authors: A. Akhmetbekova  , A. Azamatova  , N. Ibrayeva
Published: January 2023

"This article is devoted to the study of metatext elements in public speaking «TED Talks». Generally, metatext organizes the main text, structures it, helps to understand the main information and has the property of reflection. The reflexivity of metatext is manifested in its secondary nature in relation to the main text. Metatext in its narrow sense can be considered as metatext elements the function of which is auxiliary. Metatext elements are connected with the scientific text and establish a logical connection between its elements. On the basis of the typology suggested by A. Crismore metatext elements are divided into textual and interpersonal. Metatext elements are used at every stage of public speaking. The analysis of 150 metatext elements in public speeches «TED talks» starts with the examination of their introduction, body and conclusion sections. The emphasis is focused on public speeches in the field of modern technology. According to the analysis it is proved that the use of textual and interpersonal metatext elements in public speaking makes it more logical, having a positive impact on every step of preparing a speech, its structuring, and presentation to the audience, improvisation and success. "