bluuebunny/crossref_metadata_2025 huggingface dataset:
КОРХОНАЛАР МОЛИЯВИЙ ФАОЛИЯТИНИ СОЛИҚЛАР ОРҚАЛИ РАҒБАТЛАНТИРИШНИНГ ХАЛҚАРО ТАЖРИБАСИ
Authors: Бабахонов Жаъфар
Published: September 2023

Мазкур мақолада корхоналар молиявий фаолиятини солиқлар орқали рағбатлантиришнинг халқаро тажрибаси ўрганилган бўлиб, солиқ ислоҳотларини амалга оширишда хорижий мамлакатларнинг ижобий тажрибаларидан мамлакатимизда фойдаланишнинг ўзига хос хусусиятлари ва истиқболлари ёритиб берилган. Шунингдек, хорижий мамлакатлар солиқ амалиётида тақдим этилган солиқ имтиёзлари ва преференцияларнинг самарадорлигини таъминлашнинг устувор йўналишлари таҳлил қилинган.
ТИЖОРАТ БАНКЛАРИНИНГ IPO АМАЛИЁТЛАРИНИ САМАРАЛИ ТАШКИЛ ЭТИШ: МУАММО ВА ЕЧИМЛАР
Authors: Маматов Баҳромжон
Published: September 2023

Ушбу мақолада хусусий ва давлат иштирокидаги тижорат банкларида активлар ва капитал самарадорлиги кўрсаткичлари таҳлили келтирилган. Тижорат банкларида давлат улуши ва молиявий самарадорлик кўрсаткичлари ўзаро таъсири ўрганилган. Республикамиздаги тижорат банклари томонидан IPO амалиётлари орқали самарадорликни ошириш йўллари тўғрисида илмий хулосалар келтирилган.
ОНАЛАР ВА БОЛАЛАР ЎЛИМИГА ТАЪСИР ЭТУВЧИ ОМИЛЛАРНИНГ ЭКОНОМЕТРИК ТАҲЛИЛИ ХОРИЖИЙ МАМЛАКАТЛАР МИСОЛИДА
Authors: Хонтураев Бобур , Махмудов Самариддин
Published: September 2023

Мақолада хорижий мамлакатларда чақалоқлар ўлими, 5 ёшгача бўлган болалар ўлими ва аёллар ўлими ўртасидаги мураккаб муносабатларни тушунишга интилиш учун илғор эконометрик моделлардан фойдаланган ҳолда инновацион тадқиқот олиб борилди. Дунё бўйлаб 121 та мамлакатнинг маълумотларини таҳлил қилган ҳолда, ўлимнинг ушбу муҳим кўрсаткичларига таъсир этувчи омилларнинг мураккаб ўзаро таъсирини аниқлаш учун оддий энг кичик квадратлар (OLS) ва структуравий тенгламаларни моделлаштиришнинг (SEM) регрессион усулларидан фойдаланилди. Шунингдек, оналар ва болалар саломатлиги натижаларини шакллантирувчи нозик динамикани ёритишга ҳамда ўлим даражасини пасайтиришга қаратилган ёндошувлар ишлаб чиқилди. Тадқиқотда муаллифлар ёндашувлари ва таклифлари келтирилган.
DSGE MODELI (DINAMIK STOXASTIK UMUMIY MUVOZANAT MODELI)NING MOHIYATI, SHARTLARI VA FOYDALANISH METODOLOGIYASI
Authors: Rasulov Jamshid
Published: September 2023

Ushbu maqolada makroiqtisodiy tahlillarda qo’llaniladigan DSGE modelinig ta’rifi, uning strukturasi, foydalanish shartlari, hamda uning tenglamalari haqida tahlilimizni olib boramiz. Qo’shimcha ravishda, ushbu modelning boshqa modellardan farqi va uni o’rganishga hissa qo’shgan mualliflarning ushbu model bo’yicha fikrlari bilan ham ushbu maqola davomida tanishamiz.
O‘ZBEKISTONDA AHOLI DAROMADLARI VA TURMUSH DARAJASI
Authors: Xusinov Ibragim , Imamova Nasiba
Published: September 2023

Maqolada mamlakatimiz aholisining turmush darajasini bugungi kundagi holati va uni yanada yaxshilash yuzasidan xulosa hamda takliflar ishlab chiqilgan.
Osteoma periférico en la mandíbula
Authors: Martínez-Gómez Juan Carlos
Published: September 2023

El osteoma (OM) es una neoplasia benigna compuesta de hueso cortical y esponjoso, de crecimiento lento, que progresivamente aumenta de tamaño por la formación continua de tejido óseo. Según su sitio de origen, se clasifican en central, periférico y extraesquelético. Se desconoce su patogenia y se ha sugerido que pueden ser el resultado de un mecanismo reactivo ante una agresión, trauma o infección. Afectan a los adultos jóvenes, sin preferencia por sexo. Se presenta
un caso de paciente de sexo masculino de 40 años referido por presentar aumento de volumen en borde inferior del lado izquierdo de la mandíbula. Al estudio con tomografía computarizada multicorte se observó imagen hiperdensa, de bordes definidos, redondeada, localizada en zona posterior izquierda del cuerpo mandibular presentando una densidad similar al hueso cortical adyacente. La imagen mostró signos tomográficos de OM. El estudio histopatológico confirmó el diagnóstico clínico.
Canal gubernacular asociado a un diente retenido con imagen pericoronaria sugerente de lesión quística
Authors: Pérez María Fernanda , Terán María Eugenia
Published: September 2023

El canal gubernacular (CG) es un canal óseo, parte del gubernaculum dentis, compuesto por tejido conjuntivo fibroso que contiene células epiteliales, así como nervios periféricos, sangre, vasos linfáticos y restos de lámina dura, representa el paso del diente a través del hueso. La observació del CG en estudios convencionales en 2D es infrecuente, debido a que estos canales son muy delgados y se encuentran en el hueso esponjoso, no relacionado a las corticales de los maxilares, el uso de tomografía computarizada de haz cónico (TCHC) ha hecho posible su evaluación precisa. Este reporte describe un caso de CG en una paciente femenina de 13 años de edad quien fue referida para localización de diente 21 retenido mediante TCHC. Se observó en las reconstrucciones multiplanares, el diente 21 retenido en posición vertical con la corona entre tercios apicales de 11
y 22. Se evidenció imagen hipodensa pericoronaria, de bordes corticalizados sugestiva de lesión quística, así como una prolongación en forma de canal de aproximadamente 8,12 mm, cuyos bordes se aproximaban caudalmente desembocando en el reborde alveolar, que sugiere un CG. La TCHC permitió evaluar sus límites, trayecto y relación con la unidad dentaria retenida.
Los juegos tradicionales como potenciadores de la inclusión sociopsicomotriz en estudiantes de educación primaria con dificultad de aprendizaje
Authors: Mamani-Jilaja Dometila , Huayanca-Medina Pedro Carlos
Published: September 2023

In the context of primary education, the inclusion of children with learning difficulties has become a topic of great relevance and concern. In this sense, the aim of the research is to analyze the effect of the implementation of traditional physical education games on the socio-psycho-motor inclusion of children with learning difficulties in primary education. Methodologically, it was a quantitative, correlational, experimental study that used a simple random sample of 471 students from a primary education in Puno, which caters to schoolchildren with learning disabilities. For the data collection, an estimation scale type questionnaire was applied, with Likert type answers. The results of the pretest in both groups are shown in initiated, in 56.17% for the control group and 55.08 in the experimental group; after the intervention, it was appreciated that in the control group 14.47% obtained the qualification of achieved, while the experimental group was evidenced in 57.63%, the latter with a significance of 0.00 in the chi-square test, which allowed validating that there is a significant association between the use of traditional physical education games and the improvement of socio-psychomotor inclusion.

En el contexto de la educación primaria, la inclusión de niños con dificultades de aprendizaje se ha convertido en un tema de gran relevancia. En este sentido, el objetivo de la investigación es analizar el efecto de la implementación de los juegos tradicionales de educación física en la inclusión sociopsicomotriz de los niños con dificultades de aprendizaje en la educación primaria. Metodológicamente, se trató de un estudio cuantitativo, correlacional, experimental, que empleó una muestra aleatoria simple de 471 estudiantes de una educación primaria de Puno, que atiende a escolares con problemas de aprendizaje. Para la recolección de datos, se aplicó un cuestionario tipo escala de estimación, con respuestas tipo Likert. Los resultados del pretest en ambos grupos se muestran en iniciado, en 56.17% para el grupo control y 55.08 en el grupo experimental; posterior a la intervención, se apreció que en el grupo control el 14.47% obtuvo la calificación de logrado, mientras que el grupo experimental se evidenció en 57.63%, este último con una significancia de 0.00 en la prueba de chi cuadrado, lo que permitió validar que hay una asociación significativa entre el uso de juegos tradicionales de educación física y la mejora de la inclusión sociopsicomotriz.
Gaya Kepemimpinan Influence Untuk Meningkatkan Kuantitas Peserta Didik Di Smks Sagaranten
Authors: Jalaludin Bulkini  , Mulyawan Safwandy Nugraha
Published: September 2023

Leadership is a complex and unique phenomenon of social interaction, anyone will show leadership behavior when interacting in a format that influences others. Even in personal capacity, in the human body there is capacity or potential as a controller, which essentially facilitates a person to be able to lead himself.This research journal was conducted at SMKS Sagaranten which is located on the cigadog highway km.2 sagaranten sukabumi and produces the influence of the principal's leadership to increase the quantity of students.Leadership is often given the meaning of degree of influence, while the leader is the person who has the most potential to influence. Leaders who cannot actualize their influence do not have the character of true leadership. Then we must know how educational leadership is so the purpose of this article is to dig deeper into leadership and complete the task. Articles are made with techniques for gathering resources such as reading material and books on leadership.So that we can draw the conclusion that educational leadership as "one ability and process of influencing, guiding, coordinating and mobilizing other people who are related to the development of the science of education and the implementation of education and teaching, so that the activities carried out can be more efficient and effective in achieving educational and teaching goals.
Entre ushucutas y juanescas
Authors: Gallegos Anda Manuela , Viteri Chancusi Pablo , Chacón Terán María Paz , Ambuludi Silva Andrés Eduardo , Vanegas Carrera Gabriela , Pérez Vallejo Francisco , Martínez Abarca Ana Lucía , Miranda Cárdenas Ingryd , Moreno Aldaz Luciano , Lanchimba Guandinango Jhonny
Published: September 2023

Un libro hecho con ejemplar dedicación, enhebrado entre la reivindicación de nuestra herencia cultural e identitaria, la Inquisición en la historia y, más que nada, con profundo afecto a la tierra nutricia y con un sentimiento de nostalgia, hilo que vincula pretérito y presente y se proyecta a lo venidero, por sobre todas las incertidumbres. Todo ello y más constituye esta obra colectiva que reitera la fecunda gestión de la Universidad de Las Américas en la profundización del conocimiento de la cultura nacional. El énfasis particular que los autores ponen en lo tradicional, lo ancestral y en la continuidad de las costumbres familiares emparenta a casi todos estos textos, lo que les vuelve entrañables y partes de un conjunto de donde nace una certidumbre de identidad, la sustentación de una cultura que se transmite y renueva de generación en generación.Francisco Proaño Arandi
Flora y fauna de los vientos andinos
Authors: Zapata Alexis
Published: September 2023

Cuando se aborda el estudio de la etnomúsica en los países andinos, impresiona la variedad de ritmos, melodías, armonías e instrumentos musicales que, imbricados con los calendarios heliolátrico y festivos, estructuran cosmoaudiciones y paisajes sonoros de sugerentes características. En el ámbito organológico se destacan los instrumentos aerófonos, por sus múltiples formas, afinaciones, materiales de construcción y sonoridades, producto de un sostenido proceso de búsqueda y decantación sonora, iniciado hace miles de años por los habitantes de esta «América profunda». En el caso del Ecuador se han encontrado instrumentos arqueológicos aerófonos de cerámica, con una antigüedad aproximada de 3.500 años a.C., algunos con características morfológicas y acústicas de excepcionales particularidades, como las botellas silbato de la culturas Chorrera, Bahía o Jama Coaque, consideradas como las más antiguas de su género en el mundo andino
Corteza
Authors: Sandoval Ponce Ricardo , Chávez Cuesta Sebastián , Pacheco Romero Keinsky , Salazar Méndez Roberto
Published: September 2023

Uno de los legados más importantes que una institución educativa puede entregar es la trasmisión de conocimiento. Corteza es la constante búsqueda de un escenario real para reforzar lo aprendido en clase. Después de algunos años, establecimos una base importante de recetas comprobadas por toda nuestra comunidad, así que el siguiente paso fue encontrar la forma de transmitir nuestra experiencia, no solo a la comunidad UDLA, sino también a la sociedad en general. Por eso, Corteza, un espacio con historia, producto, innovación y técnica representa el esfuerzo de los profesionales y alumnos, su ímpetu por transmitir conocimiento y enaltecer los valores institucionales de la Escuela de Gastronomía.Ricardo SandovalCorteza es un libro técnico bien redactado, apto para profesionales, estudiantes, así como para amateurs o aficionados que se dedican a la panadería y pastelería en general. Su contenido tiene excelentes recetas probadas, precisas y bien calibradas, como lo requiere un texto de consulta en esta área de la gastronomía. Me complace mucho ver que un libro así preserva, cataloga y difunde recetas tradicionales o contemporáneas de la panadería y pastelería del Ecuador, así como tantas otras clásicas del mundo. Las preparaciones presentadas de una manera clara, sencilla, pero a la vez prolija, tienen el fin de guiar a quienes las utilizan, y así puedan obtener los mejores resultados. Felicito sinceramente a la UDLA y a quienes han colaborado en este gran proyecto por todo su esfuerzo y dedicación.Henry Richardson
Neutrosophic CRITIC MCDM Methodology for Ranking Factors and Needs of Customers in Product's Target Demographic in Virtual Reality Metaverse
Authors: Sleem Ahmed , Mostafa Nehal , Elhenawy Ibrahim
Published: September 2023

Affective design has come to place a premium on customer-centric creativity, which ultimately results in the creation of a product tailored to the requirements of a certain demographic. Designing a fresh and original item that appeals to clients remains challenging, despite the abundance of literature on customer-centric creativity and impact product design. This is so because optimizing technological and aesthetical design aspects and variables for a group of consumers is highly complicated, and for the same reasons that it is hard to know a customer's choice, enable the product's functioning, etc. One of the most important parts of creating cutting-edge technological items is the technical product requirement. In reality, we can generally glean insights about a product's design by looking at the hidden desires of a comparable set of potential buyers. In this study, we provide a unique combined structure for evaluating the factors and needs of customers in product design in virtual reality (VR) metaverse by merging the CRiteria Importance Through Intercriteria Correlation (CRITIC) approach with single-valued neutrosophic sets (SVNSs). The characteristic weights in this approach are calculated using the CRITIC technique. The CRITIC method computes the rank of needs. The neutrosophic set is used to overcome the uncertain data. The application of this study shows thermal dissipation, airtight construction, weight, and control mechanisms are among the most crucial considerations.
Leveraging Neutrosophic Uncertainty Theory toward Choosing Biodegradable Dynamic Plastic Product in Various Arenas
Authors: Mohamed Mona , Sallam Karam M.
Published: September 2023

Numerous studies in recent years have documented the negative effects of plastic waste on the environment and human wellness. Due to their widespread usage in daily life, particularly in packaging, and their rising direct or indirect discharge into the environment, plastics are recognized as an emerging environmental hazard. Thus, this point is considered the first problem in this study. As a result, efforts to replace traditional plastics with bioplastics have intensified. However, studies regarding the effects of conventional and bioplastics (BioPs) are also important. Hence, biodegradable polymers for industrial and commercial usage are essential in the present day as an alternative to traditional plastic. Another point considered in this study is packaging which entails the quest for new natural materials that may be included in the production of reusable, eco-friendly, and long-lasting flexible polymers. Prior studies demonstrated that starches from both tubers and grains may be processed into malleable biopolymers. Since the quality of the carbs from different vendors varies, choosing which one to work with presents a Multi-Criteria Decision-Making (MCDM) challenge. This paper proposed a neutrosophic MCDM methodology to select the best biodegradable dynamic plastic product (BDPP). The neutrosophic method is used to overcome uncertain data. The neutrosophic is integrated with the Additive Ratio Assessment (ARAS) method. The weights of the criteria are computed then the rank of BDPP is obtained by the neutrosophic ARAS method.
Toward Sustainable Emerging Economics based on Industry 5.0: Leveraging Neutrosophic Theory in Appraisal Decision Framework
Authors: Mohamed Mona , Gamal Abduallah
Published: September 2023

Entrepreneurs in emerging economies (EEs) need to expand to survive in a climate of intense competition. Additionally, it must be innovative, imaginative, and open to absorbing new business techniques.  Prior studies proved that Entrepreneur’s success hinges on its capacity to deliver innovative items through employing cutting-edge technologies more quickly than its rivals. In recent decades, digitization—the widespread use of connected digital services by governments, businesses, and consumers—has emerged as a major economic engine that spurs expansion and makes it easier to create jobs. For instance, the next major technological shift is thought to be Industry 5.0 (Ind 5.0). In contrast to Industry 4.0, its goal is to provide manufacturing techniques that are resource-efficient and user-preferred through leveraging the creativity of human specialists in combination with effective, intelligent, and precise machines. Hence, the current study seeks to compile a comprehensive list of obstacles that suppress implementing Ind5.0, to experimentally appraise those obstacles. We construct Appraisal Decision Framework (ADF) generated from deploying Analytic Hierarchy Process (AHP) as method of multi-criteria decision-making (MCDM). Whilst AHP work with aids of neutrosophic set to overcome the vague information in the process of evaluation. Herein, interval-valued neutrosophic numbers (IVNSs) apprise the obstacles of Ind 5.0 in EEs. The neutrosophic AHP method is used to compute the weights of risks, then rank it. The findings of ADF show that cost and fund are the highest in all 12 obstacles, followed by scalability, Lack of Socio-technological Planning, security, and privacy.
Ranking and Analysis the Strategies of Crowd Management to Reduce the Risks of Crushes and Stampedes in Crowded Environments and Ensure the Safety of Passengers
Authors: Al-Nami Waleed Tawfiq
Published: September 2023

Public gatherings, transit hubs, stadiums, and crowded retail malls are just a few examples of places where crowd management has become an urgent issue in recent years. Effective crowd management strategies have been required due to the increasing population, urbanization, and frequency of large-scale meetings. These strategies are used in dynamic, sometimes chaotic, circumstances to protect people and facilitate their free movement. The purpose of this study is to analyze and rank various strategies for crowd management to reduce the risks of crushes and stampedes, improve security, and facilitate smoother traffic flow. This study used the single-valued neutrosophic set to deal with uncertain and vague information in the evaluation process. There are various factors in ranking the various strategies. So, the concept of multi-criteria decision-making (MCDM) is used to deal with various criteria. The neutrosophic set is integrated with the MCDM methodologies to rank various strategies. This study used the analytical hierarchy process (AHP) method to compute the weights of factors. Then the technique for order preference by similarity to the ideal solution (TOPSIS) method is used to rank the various strategies. An application was conducted to apply the proposed method. The outcome shows the safety and security factor is the heights important. The sensitivity analysis is applied to show the rank of strategies under various weights of factors. Finally, comparative analysis is applied to show the robustness of the proposed method compared with other MCDM methods.
Covering Properties via Neutrosophic b-open Sets
Authors: Dey Sudeep , Ray Gautam Chandra
Published: September 2023

The purpose of this article is to study some covering properties in neutrosophic topological spaces using neutrosophic b-open sets. We define neutrosophic b-open cover, neutrosophic b-compactness, neutrosophic countably b-compactness neutrosophic b-Lindelofness, neutrosophic local b-compactness and study various properties entangled with them. We study some covering properties involving neutrosophic continuous, neutrosophic b-continuous and neutrosophic b*-continuous functions. Lastly, we define neutrosophic base, neutrosophic subbase, neutrosophic second countability via neutrosophic b-open sets and investigate some properties.
Blended Learning en el aprendizaje de idiomas: Una revisión de la literatura académica
Authors: Martínez Hernández Roberto
Published: September 2023

El presente estudio se enfoca en la estrategia metodológica de Blended Learning (B-learning) aplicada al aprendizaje de idiomas. Esta modalidad combina elementos presenciales y virtuales, incorporando tanto encuentros sincrónicos como asíncronos, aprovechando las Tecnologías de la Información y Comunicación (TIC). El objetivo del estudio fue evaluar el impacto de esta estrategia en el aprendizaje de idiomas. Se utilizó un enfoque cualitativo con un paradigma interpretativo, un diseño documental y alcance explicativo. La revisión de la literatura se centró en artículos de revistas indexadas en Latindex, SciElo, Ebsco, Scopus y Web of Science relacionados con el tema. Los resultados destacan que el B-learning se presenta como una solución a ciertos desafíos encontrados en la educación presencial. En conclusión, la adquisición de competencias en un idioma distinto al nativo es fundamental para aumentar las oportunidades educativas y laborales, especialmente en el contexto de la globalización. La estrategia metodológica B-learning contribuye significativamente al aprendizaje de idiomas mediante el uso de diversos recursos tecnológicos que fomentan la motivación en los estudiantes, aportan dinamismo a las actividades de aprendizaje y fomentan el aprendizaje autónomo y colaborativo.
Calling the User
Authors: Niederberger Shusha
Published: September 2023

In recent years, a large body of work has analyzed the cultural and social ramifications of data-driven digital environments that currently structure digital practice. However, the position of the user has scarcely been developed in this field.

In this paper I discuss how user subject positions are invoked by digital infrastructures as an alternative to big technology platforms. With subject positions I mean a shared and often unarticulated understanding of what kind of technological practice is meant when we talk about users: user as a cultural form. I start with the analysis of a crisis in user subjectivity as it manifested in the migratory waves from Twitter to Mastodon at the end of 2022, after Elon Musk bought Twitter. Like Twitter, Mastodon is a microblogging service, but it operates as a network of connected servers run by nonprofit organizations and communities. I argue that Mastodon—by way of its infrastructural organization around servers and communities—invokes a different subject position of the user than the self-contained autonomous liberal subject, one that is based on a relationship with a community. In a second case study, I discuss how the artistic activist practices of Trans*Feminist Servers create a territory to rethink relations to technology itself, most prominently through raising questions of servitude: what does it mean to serve and to be served? I argue that through this, Trans*Feminist Servers are able to reformulate use as part of relations of care and maintenance and implement them in their technological practice. As I conclude, both Mastodon and Trans*Feminist Servers project a user exceeding the neoliberal subject. While Mastodon does so by proposing a subject position related to a community first, Trans*feminist Servers go a step further and moreover open use as a practice beyond consumption, thus operate on relations to infrastructure itself.
Influenza virus transcription and progeny production are poorly correlated in single cells
Authors: Bacsik David J , Dadonaite Bernadeta , Butler Andrew , Greaney Allison J , Heaton Nicholas S , Bloom Jesse D
Published: September 2023

The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. However, most single-cell studies of infection quantify the expression of viral transcripts and proteins, rather than the amount of progeny virions released from infected cells. Here, we overcome this limitation by simultaneously measuring transcription and progeny production from single influenza virus-infected cells by embedding nucleotide barcodes in the viral genome. We find that viral transcription and progeny production are poorly correlated in single cells. The cells that transcribe the most viral mRNA do not produce the most viral progeny and often represent aberrant infections that fail to express the influenza NS gene. However, only some of the discrepancy between transcription and progeny production can be explained by viral gene absence or mutations: there is also a wide range of progeny production among cells infected by complete unmutated virions. Overall, our results show that viral transcription is a relatively poor predictor of an infected cell’s contribution to the progeny population.
The Effect of Siddha Medicine in Treating Autism Spectrum Disorder: A Case Report
Authors: Elangovan Preetheekha , Ramasamy Gomathi , Ananthathandavan Priyadharshini , Malayappam Meenakshi Sundaram
Published: September 2023

The heterogeneity, complexity, co-occurring conditions, and lifelong impact are unique features of Autism Spectrum Disorder (ASD), making it a challenging disorder to diagnose and treat. The Siddha medicinal system offers a comprehensive approach to health that extends beyond the corporeal realm. It encompasses emotional, social, spiritual, and intellectual aspects of well-being. Siddha medicine is unique in its holistic approach to healthcare, emphasising the overall well-being of an individual rather than just treating symptoms. It focuses on balancing the body’s three humours, or doshas, to restore equilibrium. This case report describes a 10-year-old male with behavioural complications and Gastrointestinal (GI) symptoms diagnosed with Mantha sanni (ASD). The patient received specialised Siddha interventions, including Amukkara chooranam, Brahmi nei, Mantha ennai, and Varmam (a form of external manipulation). The study evaluated the treatment outcome over 90 days using the Indian Scale for Assessment of Autism (ISAA). The child showed significant improvement in all areas of the ISAA scale, including social relations, language and communication skills, behavioural patterns, emotional responsiveness, cognitive functions, and sensory perception. The overall score, previously indicating moderate autism at 159, improved to 100, indicating mild autism, after treatment. This case report contributes to the scientific literature by providing novel insights into alternative medicine treatments for individuals with ASD. These treatments can help them lead satisfying lives and enhance their quality of existence.
Intravenous Low Dose (4 mg) Dexamethasone as an Adjunct to Epidural Labour Analgesia with 0.125% Ropivacaine in Parturients: A Randomised Controlled Study
Authors: Kumar Jagdish , Choudhary Garima , Tanwar Gayatri , Ujwal Shobha
Published: September 2023

Introduction: Labour pain is one of the most severe pains, and the mother’s demand is reason enough for the induction of labour analgesia, provided that no contraindications exist. Labour analgesia must be safe for both the mother and the child. Aim: To assess the impact of a low dose (4 mg) of intravenous (IV) dexamethasone used in conjunction with neuraxial labour analgesia with 0.125% Ropivacaine. Materials and Methods: The present study was a doubleblinded randomised controlled study conducted at tertiary care hospital on 80 parturients classified as American Society of Anaesthesiologists (ASA) II. The parturients were over 18 years old, in their third trimester, carrying a single live foetus that was cephalic at 36 weeks of gestation, and whose cervical dilation was greater than 3 cm and who requested epidural analgesia. All parturients were randomly divided into two equal groups. Before receiving epidural analgesia, the dexamethasone group received 4 mg of IV dexamethasone in 50 mL of normal saline. Patients in the control group received only 50 mL of normal saline. After an initial bolus of 0.125% ropivacaine (8 mL given gradually over 5 minutes), all expectant mothers received a continuous background infusion of 0.125% ropivacaine at a rate of 5 mL/h, along with patient-controlled boluses of 5 mL of the same medication given with a lockout interval of 12 minutes using a Patient Controlled Epidural labour Analgesia (PCEA) pump through the epidural route. Yates continuity correction test (Chi-square test), Fisher’s exact test, and Fisher Freeman Halton were used to compare qualitative data. For categorical data, numbers and percentages were used to summarise all continuous variables as mean±SD. Results: Demographics such as age, height, weight, and preprocedure obstetric-related details were comparable in both groups. There was no statistically significant difference in the average hourly medication intake between the dexamethasone group and the control group (Group D-7.64±0.88 mL/hr and Group C-8.04±1.24 mL/hr, p-value=0.09). Other factors, including pain scores, haemodynamics, administration method, and side effects, did not differ significantly between the two groups. Conclusion: Despite having modest analgesic properties, IV dexamethasone could not significantly reduce the hourly average medication consumption of ropivacaine during epidural labour analgesia.
Trends in the rescue and fate of koalas in New South Wales (1973-2020), with a focus on disease and trauma
Authors: Lunney Daniel , Cope Holly , Griffith Joanna , Orcheg Corinna , Bryant Jessica , Haering Ron
Published: September 2023

In line with the objectives of both the 2022 National Recovery Plan for the Koala Phascolarctos cinereus and 2022 NSW Koala Strategy, our study aimed to draw on the long-term records of koala rescue in NSW from 1973 to 2020 to describe trends in admissions across NSW. A total of 18,039 koala admission records were collated from 1973 to 2020. Koalas were rescued due to disease, motor vehicle collision, dog attacks, unsuitable environment, bushfire, orphaning, and other reasons. However, the reasons for rescue were not evenly distributed among the rehabilitation groups. Across all rehabilitation groups and all years (1973-2020), the release rate of all admitted koalas was 47.6%. The NSW Koala Strategy identifies an action of “supporting koala rehabilitators” (Pillar 3 Improving the safety and health of koalas), and strong partnerships, including with koala rehabilitators, are “critical to achieving success”. Our study has confirmed that strong partnerships are possible and identified the prevalence of disease and trauma in rescued koalas. While it is not possible to assess the scale of the threats from disease and trauma to koala populations from rehabilitation records alone, we can use the trends in admissions to inform the efficient distribution of resources to rescue and rehabilitation efforts.
Comparative Study on Snacking Behaviour and Pattern of Working and Non-Working Women of Hisar City, India
Authors: Rani Nisha , Geeta
Published: September 2023

The present study was conducted to assess and compare the snacking behavior of working and non-working women of Hisar City. The aim of the present study was to compare snacking behavior of working and non-working women of Hisar City. For this study, a sample of one hundred and twenty women in age 25-45 years, 60 each working and non-working women were drawn randomly from Hisar city. The sample of working women included 20 each engineer, advocates, and teaching professionals. Non-working women were selected having an income, and age similar to their counterparts. Information on snacking behavior like the preference for snacks over regular meals, time and place of snacking, types of snacks taken, and source of procuring snacks, etc. were recorded in the questionnaire. The data indicated that mere 15 percent of working and 23.3 percent of non-working women preferred snacks over regular meals. The majority (90.0%) of respondents preferred to take salty snacks followed by sweet (85.0%) and sweet and salty (56.7%). The result revealed that non-working women have more cravings for snacks than working women but they prefer more of homemade snacks to outside snacks.
The Evaluation of Obstetric Outcome of Postdated Pregnancy
Authors: Aktar Most. Zakia , Arman Rumana , Islam Mohammad Shahnur
Published: September 2023

Background: Postdated pregnancy is one of the commonest obstetric conditions. Pregnancy is called term when it lies between 37 weeks to 40 weeks from the last menstrual period. If the pregnancy exceeds 40 weeks it is called as postdated pregnancy.

Methods: From January to June 2022, researchers from the Research institute Dhaka Medical College and Hospital, carried out this prospective observational study. We surveyed 100 participants for this research. After carefully evaluating the woman and the fetus, induction of labor was conducted after the due date had passed. Intact membrane, cephalic presentation, singleton pregnancies, and a low Bishop score in post-dated pregnancies were also requirements for participation. Women with absolute contraindications to induction of labor, such as a contracted pelvis, placenta previa, unexplained vaginal hemorrhage, breech presentation, or a history of caesarean section, were not included in the analysis.

Results: During the study Sixty percent of the population is comprised of young adults ages 21 to 30. There were 42% in the oxytocin group, 38% in the ARM + oxytocin group, and 14% in the misoprostol group. There were 30% unsuccessful deliveries with oxytocin drip, 25% with ARM + Oxytocin drip, and 14% with misoprostol. The vast majority of births occurred naturally via the cervix, whereas around 33% required a caesarean section and 10% required the use of forceps. The fetal distress rate was 13%, while the cervix conditions were poor in 5%. 75% of the newborns were very fine.

Conclusion: Timely labor is closely connected with positive birth outcomes. It is critical to make a correct diagnosis of postdatism. With the right advice and constant monitoring from medical professionals, postpartum depression in mothers may be alleviated. Many hospitals around the country resort to caesarean sections to end post-dated pregnancies because of technological limitations in foetal monitoring and oxytocin titration. Inducing labor seems to be safe for both mother and child when a full-term cervix and favorable fetal presentation are present.
Formulation and Standardization of Gujarati Snack (KHAKHRA) Fortified with Whole Unripe Pumpkin (Cucurbita moschata) Powder
Authors: Patel Pankti , Singh Sury Pratap
Published: September 2023

The present investigation, entitled “Formulation and standardization of Gujarati snack (khakhra) fortified with whole unripe pumpkin (Cucurbita moschata) powder” was conducted in the Department of Food Technology, Parul University. The goal of this study was to develop khakhra fortified with whole unripe pumpkin powder. The khakhra was prepared using oats, maize and wheat flour along with developed pumpkin powder. The black pepper, cumin and carom seed powder were used as seasoning. The developed product was examined for various physicochemical attributes, including storage stability and the FT-IR procedure for the identification of functional groups which signify various bioactive compounds. The nutritional composition of khakhra obtained showed the presence of protein, fat, carbohydrates, refibre calcium, magnesium, iron and zinc content as 10.83 per cent, 13.86 per cent, 69.95 per cent, 5.34 per cent, 10.83 mg/100g, 182.65 mg/100g, 5.27 mg/100g and 2.49 mg/100g respectively. The developed khakhra was packed in polyethene and stored for 3 months under refrigeration conditions (4oC) and ambient conditions (18-38oC) storage studies.
Effect of Tillage Management and Soil Slope on Annual Soil Loss under Cereal Crops in Central India
Authors: Manekar Urwashi , Sharma S. K. , Trivedi S. K. , Meena Harimohan
Published: September 2023

The negative impacts of soil erosion on productivity are mainly attributed to the decline in soil fertility and water availability. Continuous tillage practices combined with removal of crop residue from the soil surface greatly increase the risk of soil erosion and nutrient depletion. Soil erosion creates many adverse impacts on the environment and soil health which influence the food security and the quality of life. In present study the effect of three tillage management (conventional tillage, ridge and furrow system and no tillage system) and soil slopes (1%, >1% to < 3%, >3 to <5% and >5%) on soil loss in twelve different soil series under cereal cropping in central India has been studied. The results of the study indicated that the tillage management plays an important role to reduce soil loss. No tillage system found showed minimum annual soil loss whereas the conventional tillage practice recorded the most. The soil loss found decreased with decrease in slope and vice-versa. The Bararia soil series found most vulnerable to the soil loss whereas the Dhodar soil series found resistant to soil loss across the slopes and tillage management practices studied under cereal cropping in central India.
Knowledge and Utilization of the Glasgow Coma Scale (GCS) in Evaluating Unconscious Patients among Clinical Nurses in a Nigerian Referral Health Centre
Authors: A. U. Galadima,
Published: September 2023

Introduction: Glasgow Coma Scale (GCS) is the foundation of the neurological appraisal of patients utilized by both nursing and clinical staff. The study was conducted to ascertain the level of knowledge, utilization and variables that prevent nurses using the GCS to evaluate unconscious patients at the teaching hospital of Modibbo Adama University in Yola, Adamawa state, Nigeria. Materials and Methods: The study utilized descriptive research cross-sectional design. the sample size for the study was calculated using Taro Yamane’s method, a structured questionnaire was administered to 131 respondents to collect data for the study out of which 117 were successfully filled and retrieved. Data collected was analysed and presented on tables.

Finding: The findings revealed that more than half of the respondents (60%) were female with post basic nursing qualification, majority (61%) of the nurses surveyed were knowledgeable of GCS, 88% & 84% of respondents respectively reported that lack of knowledge regarding the GCS’s use and not having self-confidence regarding the application of GCS were the main factors that hindered them to their capacity to apply the GCS in their routine practice.

Conclusion: It was concluded that the study subjects had good knowledge of GCS, so also utilization status of the GCS was very good.

Recommendation: Based on the findings, it was recommended that Nurses must work harder to stay current with their knowledge and practice doing the GCS examination, and management should create an educational team to evaluate, instruct and make sure that nurses adhere to utilizing the GCS appropriately.
Neoadjuvant Immune Checkpoint Inhibitor Therapy for Localized Deficient Mismatch Repair Colorectal Cancer
Authors: Emiloju Oluwadunni E. , Sinicrope Frank A.
Published: September 2023

Importance

Colorectal cancers (CRCs) with deficient DNA mismatch repair (dMMR) account for 15% of all CRCs. Deficient MMR is a predictive biomarker associated with responsiveness to immune checkpoint inhibitors (ICIs) in solid tumors, including CRC. The remarkable effectiveness of ICIs in metastatic CRC has led to their evaluation in the neoadjuvant and adjuvant treatment of localized disease.

Observations

Multiple prospective phase 2 studies in limited numbers of patients with localized dMMR CRC demonstrate high complete clinical and pathological response rates (60%-100%) to neoadjuvant ICIs, with low rates of grade 3 or higher ICI-related toxic effects. Given the median follow-up of 12 to 25 months in these studies, longer-term monitoring is needed to determine the durability of response and to ensure that oncologic outcomes are not compromised in patients undergoing nonoperative management. Neoadjuvant ICI therapy is especially attractive for patients with rectal cancer given the significant morbidity that accompanies pelvic irradiation and total mesorectal excision. Ongoing and planned prospective phase 2 trials will provide further data on important issues, including optimal neoadjuvant treatment duration, ICI monotherapy vs combination, and the need for adjuvant ICI therapy.

Conclusions and Relevance

While this review found that early results of neoadjuvant immunotherapy for localized dMMR CRC show high rates of major and complete pathological response, longer-term follow-up data are needed to ensure that oncologic outcomes are not compromised and are ideally improved. Neoadjuvant ICI therapy in localized dMMR CRC represents a potential paradigm shift with implications for organ preservation.
Elexacaftor-Tezacaftor-Ivacaftor Therapy for Chronic Sinus Disease in Cystic Fibrosis
Authors: Sheikh Shahid , Ho Mai-Lan , Eisner Mariah , Gushue Courtney , Paul Grace , Holtzlander Melissa , Johnson Terri , McCoy Karen S. , Lind Meredith
Published: September 2023

Importance

Cystic fibrosis (CF) is a multiorgan genetic disease with progressive upper and lower airway involvement. The effects of CF transmembrane conductance regulator (CFTR) modifier therapies on CF-related upper airway disease, specifically chronic rhinosinusitis (CRS), are not characterized.

Objective

To determine the outcome of elexacaftor-tezacaftor-ivacaftor (ETI) on CRS as measured by changes in sinus computed tomography (CT) metrics and on clinical parameters in individuals with CF.

Design, Setting, and Participants

This prospective longitudinal cohort study was conducted at the CF center of a tertiary care hospital between October 1, 2019, and July 31, 2021. A total of 64 participants with CF were included in the analysis.

Intervention

Sinus CT was obtained within 1 month of initiation of ETI therapy (baseline), and within 1 month of 1 year of ETI therapy. Images were independently analyzed by pulmonology, radiology, and otolaryngology physicians, using the Lund-Mackay and Sheikh-Lind scoring systems. Percent predicted forced expiratory volume in 1 second (ppFEV1), body mass index (BMI), and microbiologic data collected at initiation of ETI therapy and 3-month intervals for 1 year were also measured.

Main Outcomes and Measures

The study hypothesis was that ETI therapy will improve CRS as measured by changes in sinus CT at initiation and 1 year after ETI therapy and clinical parameters in individuals with CF.

Results

Among the 64 participants (39 [60.9%] female; median age, 18.5 [IQR, 16.0-28.5] years; 64 [100%] White), improvement in CRS was noted by improvements in sinus CT scans using both sinus CT scoring systems after 1 year of ETI therapy. The reduction in the median total score using the Lund-Mackay sinus CT scoring system (from 5.8 [IQR, 5.0-7.0] to 3.3 [IQR, 2.6-4.2]) and the Sheikh-Lind scoring system (from 3.8 [IQR, 3.0-5.0] to 2.2 [IQR, 2.0-2.5]) was noted. Increases in ppFEV1 and BMI were also observed by 3 months of ETI therapy with persistent improvement through 1 year of treatment. Similarly, after 1 year of ETI therapy, participants with CF had reductions in positivity for Pseudomonas aeruginosa and Staphylococcus aureus in oropharyngeal cultures.

Conclusion and Relevance

This cohort study found that use of ETI therapy was associated with improved CRS outcomes in participants with CF as quantified by improved sinus CT scans measured by 2 radiographic scoring systems and was also associated with improved clinical outcomes. Despite improvement in CT scan scores, most people with CF continue to have scores that indicate severe sinus disease.
Mastering Digital Media for Workers, Employers, and Our Community of Practice
Authors: Lum Max
Published: September 2023

Before health and safety information can be used to make policy or designed to change behavior, it must be contextually translated and disseminated within a social context. The communication process is a social process. It is therefore critical that our digital media strategies are designed to share our ideas within a more social context. Ideally, digital marketing interventions to change behavior should include social strategies for extending the reach of relevant information, moving our audiences to engage with the information, and finally stimulating activities for action. Health and safety professionals can extend the reach of useful safety and health information and assist the knowledge‐translation process by understanding the current digital media landscape and utilizing the appropriate digital platforms to include, but not limited to, social media, social video, Wikipedia, smartphone‐assisted apps, and wearables. Safety standards, guidelines, and knowledge gained from peer‐reviewed journals and evidence‐based practice are helpful resources for new learning, but information must be put into a more social context to reach and engage users. Dissemination is not engagement, and engagement is not action, but they are key parts of the digital media continuum moving essential information into practice. Having a huge social media presence does not assure action by our target audiences. As safety and health practitioners, we love to share evidence‐based findings, but we must constantly strive to understand and utilize effective and relevant social strategies to move our users beyond reach to engagement and impact.
Simulation as a tool to model potential workflow enhancements in radiotherapy treatment pathways – A systematic review
Authors: Robinson Andrew , Asaduzzaman Md , Jena Raj , Naemi Roozbeh
Published: September 2023

This systematic review aimed to synthesize and summarize the use of simulation of radiotherapy pathways. The objective was to establish the suitability of those simulations in modeling the potential introduction of processes and technologies to speed up radiotherapy pathways. A systematic literature search was carried out using PubMed and Scopus databases to evaluate the use of simulation in radiotherapy pathways. Full journal articles and conference proceedings were considered, and the search was limited to the English language only. To be eligible for inclusion, articles had to model multiple sequential processes in the radiotherapy pathway concurrently to demonstrate the suitability of simulation modeling in typical pathways. Papers solely modeling scheduling, capacity, or queuing strategies were excluded. In total, 151 potential studies were identified and screened to find 18 relevant studies in October 2022. Studies showed that various pathways could be modeled, including the entire pathway from referral to end of treatment or the constituent phases such as pre‐treatment, treatment, or other subcomponents. The data required to generate models varied from study to study, but at least 3 months of data were needed. This review demonstrates that modeling and simulation of radiotherapy pathways are feasible and that model output matches real‐world systems. Validated models give researchers confidence to modify models with potential workflow enhancements to assess their potential effect on real‐world systems. It is recommended that researchers follow best practice guidelines when building models to ensure that they are fit for purpose and to enable decision makers to have confidence in their results.