bluuebunny/crossref_metadata_2025 huggingface dataset:
Crosstalk between hemostasis inhibitors and cholesterol biomarkers in multiple sclerosis
Authors: Parambi Robert , Ziliotto Nicole , Bernardi Francesco , Baroni Marcello , Browne Richard W , Jakimovski Dejan , Weinstock-Guttman Bianca , Zivadinov Robert , Ramanathan Murali
Published: October 2022

The individual roles of cholesterol pathway biomarkers (CPB) and hemostasis inhibitors with neuroimaging outcomes were previously investigated in multiple sclerosis (MS). The purpose of this extension study was to investigate potential crosstalk between plasma CPB [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and apolipoproteins (Apo) ApoA-I, ApoAII, ApoB, ApoC-II and ApoE] and hemostasis inhibitors [heparin cofactor-II (HCII), protein C (PC), protein S (PS), thrombomodulin, ADAMTS13 and PAI-1] in a cohort of 127 MS patients, and 40 healthy individuals (HI). The associations were assessed with regressions. In MS patients, HCII was positively associated with TC, LDL-C, HDL-C and ApoA-I (p=0.028, 0.027, 0.002 and 0.027, respectively) but negatively associated with ApoCII (p=0.018). PC was positively associated with ApoC-II (p=0.001) and ApoB (p=0.016) whereas PS was associated with TC (p=0.024) and ApoE (p=0.003) in MS. The ApoC-II associations were not observed in HI. The negative association between ApoC-II and HCll was an exception amongst other positive associations between CPB and hemostasis inhibitors in MS. CPB do not modulate the PC associations with neurodegeneration in MS.
Journal metrics, document network, and conceptual and social structures of the Korean Journal of Anesthesiology from 2017 to July 2022: a bibliometric study
Authors: Huh Sun
Published: October 2022

Background: This study aimed to identify the directions of research published in the Korean Journal of Anesthesiology (KJA) and identify the main topics and journal network through a bibliometric analysis. The results can be reflected in strategies for the journal’s promotion to a top-ranking journal in the anesthesiology category.Methods: KJA articles from January 1, 2017 to September 11, 2022 were retrieved from the Web of Science Core Collection on September 11, 2022, and analyzed using Biblioshiny. Journal metrics, the document network, the conceptual structure, and social structures were elucidated. Results: Out of 525 articles, fewer than half (48.6%) were from Korean corresponding authors. The impact factor steeply increased from 2.316 in 2019 to 5.167 in 2021. The Hirsch index of KJA was 24. A co-occurrence network of Keywords Plus showed four clusters of central keywords: surgery, management, anesthesia, and mortality. The conceptual structure map of Keywords Plus showed a main cluster of anesthesia and analgesia, while another minor cluster included intubation and induction. The co-citation network demonstrated that KJA was in the same cluster of anesthesiology journals. The collaboration network of the authors’ countries showed that Korean authors collaborated mainly with researchers in the United States and Canada.Conclusions: These results show KJA’s developmental process of promotion to a top-tier journal in the anesthesiology category. Furthermore, the following strategies are suggested for journal promotion: recruitment of articles on emerging and highly citable topics; and more active collaboration of society members with researchers worldwide.
A Correlational Study on Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Bronchial Asthma
Authors: Tahseen Rabia , Parvez Mohammad , Kumar G Sravan , Jahan Parveen
Published: October 2022

Introduction:

Inflammation is an integral component of bronchial asthma associated with hyperresponsiveness and chest tightness. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been proven as independent inflammatory markers in various conditions. This study is an effort to evaluate the correlation between these two markers in asthma.

Materials and Method:

With the approval of the Ethical Committee, Osmania Medical College, Hyderabad, 194 subjects were enrolled for the current study. Out of which, 122 were proven asthmatics diagnosed by pulmonologist and 72 non-asthmatic healthy volunteers. Blood samples were collected from all the individuals and subjected to complete blood count. NLR and PLR were calculated and analysed for each study group. The continuous data were expressed as mean ± standard deviation and Student's t-test. The correlation analysis was performed between the various groups.

Results:

A statistically significant difference was noted with respect to NLR and PLR between asthma patients and non-asthmatic healthy controls (P = 0.0001). NLR alone varied significantly between responders (mild asthmatics) and poor responders (moderate asthmatics) of the patient group. Further, a positive correlation was noted between NLR and PLR in all the categories, with the highest value in the poor responders. The results are indicative of strong interdependency of NLR and PLR in a condition with higher inflammation.

Conclusion:

Future studies are warranted to explore this relation in understanding the disease severity/drug response to monitor or to identify the better drug target.
A Novel Convolutional Neural Network–Fuzzy-Based Diagnosis in the Classification of Dental Pulpitis
Authors: Chauhan Rahulsinh Bhupendrasinh , Shah Tejas V , Shah Deepali H , Gohil Tulsi Jaduvirsinh
Published: October 2022

Introduction:

This study presents a computer-aided decision-making system based on the convolutional neural network (CNN)–fuzzy approach. According to the literature, there is a lack of coherence amongst dentists in diagnosing reversible or irreversible pulpitis. As a result, the goal of this research is to assist dentists in accurately diagnosing pulpitis.

Materials and Methods:

A rigorous algorithm that relies on CNN-fuzzy logic has been designed to handle inaccurate and ambiguous values of dental radiographs, as well as signs and symptoms of pulpitis. To begin, the probability of cavity for each class was determined using an independently designed CNN approach, which was then applied in combination with symptoms associated with pulpitis to a fuzzy knowledge base with 665 rules and the Mamdani inference algorithm to diagnose pulpitis and make recommendations to the dentist.

Results:

The CNN-fuzzy approach's results are compared to the dentists' recommendations. With the assistance of five professional dentists, the sensitivity, specificity, precision, accuracy, f1 score and Matthews correlation coefficient are calculated from 100 randomly generated sample cases. The CNN-fuzzy approach has a 94% accuracy, which is 7% higher than expert prediction. It is observed that the proposed approach produces results that are consistent with the dentists' diagnoses.

Conclusion:

The accuracy of the proposed computer-aided decision-making system for pulpitis increases dentists' confidence in diagnosing reversible and irreversible pulpitis and reduces false diagnoses due to ambiguous values of dental radiographs, signs and symptoms.
Epidemiology and ventilation characteristics of confirmed cases of severe COVID-19 pneumonia admitted in intensive care unit (EPIC19): A multicentre observational study
Authors: Havaldar Amarja A. , Kumar M Vinay , Vijayan Balaji , Prakash Jay , Kartik Munta , Sangale Atul
Published: October 2022

Background and Aims:

Coronavirus disease (COVID)-19 has spread across the globe. For a country like India with limited resources and a high population, it is worth knowing how these patients were managed. This prospective study was aimed to evaluate the patient characteristics and risk factors associated with mortality.

Methods:

The study was conducted from 15 June 2020 to 31 December 2020 in four centres across India. Patients above 18 years of age admitted in the intensive care unit (ICU) with severe COVID-19 pneumonia were included. Details of oxygen therapy and ventilator characteristics were collected for seven days.

Results:

Of 667 patients included in the study, the average age was 57 (standard deviation (SD) = 15) years and 70.46% were male. The ICU mortality was 60%. Acute physiology, age and chronic health evaluation (APACHE II) score was 29.8 (SD = 6.1). Among various significant risk factors, the need for invasive ventilator support on day 1 [odds ratio (OR): 3.11, 95% confidence interval (CI) (1.91-5.08)] and the development of arrhythmia [OR 3.85 CI (1.69,8.77) confidence interval (CI) (1.69, 8.77)] had higher odds of mortality. PF ratio [partial pressure of arterial oxygen/fraction of inspired oxygen] was 109.31 (77.79–187.26), maximum positive end-expiratory pressure was 10.29 (3.5) cmH2O, driving pressure was 18.22 (6.16) cmH2O, static compliance was 24.20 (8.57) ml/cmH2O and dynamic compliance was 17.55 (5.18) ml/cmH2O on day 1. Proning was used in 67 (22.41%) intubated patients and 44 (11.96%) awake patients.

Conclusion:

In this cohort of patients, ICU mortality was 60%. The reason for higher mortality could be the severity of illness as suggested by day 1 PF ratio and APACHE II score.
Dynamometer based hand grip strength as a clinical tool for objective assessment of post-operative residual muscle weakness
Authors: Krishna Prasad Ch Rama , Pratyusha A. Chaitanya , Sharmila Chaganti , Durga Padmaja , Sowjanya K , Harika Kandala
Published: October 2022

Background and Aims:

Residual neuromuscular block continues to be a significant postoperative complication despite neuromuscular monitoring. This study aims to determine the applicability of a hand-held forced dynamometer for hand grip strength assessment as an objective measure of residual muscle weakness.

Methods:

The study included patients undergoing surgery under general anaesthesia. A demonstration was given to the patient on the usage of a dynamometer for handgrip strength and a peak expiratory flow meter for peak expiratory flow rate (PEFR) and baseline values were recorded. The parameters were monitored at 15 minutes post-extubation and again at intervals of 15 minutes until one hour, half-hourly until four hours, and hourly until six hours post-operatively. Paired t-test was used for comparison of baseline muscle strength and PEFR with the parameters at different time points. Association between muscle strength and PEFR was tested with the Pearson-correlation test.

Results:

Muscle strength was 50 to 60%, 75% and 100% of baseline at 15, 45 and 210 minutes after extubation, respectively. PEFR was 50 to 60%, 75% and 100% of baseline at 15, 60 and 180 minutes after extubation. The Pearson-correlation test established a positive correlation between handgrip strength and PEFR (correlation-coefficient 0.86).

Conclusion:

A significant reduction in the postoperative muscle strength can be detected using an objective forced dynamometer to measure handgrip strength even when train of four count has returned to unity and even when there are no clinical signs of muscle weakness. The residual muscle weakness is significant enough to affect the PEFR in the postoperative period.
Effect of SARS-CoV-2 Vaccination on Severity and Outcome of COVID-19 among Health-care Workers of a Tertiary Care Hospital in India
Authors: Gaind Rajni , Gupta Neeraj K. , Nath Ravindra , Srivastava Nilushree , Gahlot Tanushree , Ish Pranav , Gupta Nitesh
Published: October 2022

Introduction:

SARS-CoV-2 vaccines decrease the risk of infection. However, data on the utility of vaccines in decreasing the severity of COVID-19 need to be evaluated. This study was carried out with the primary objective to assess the severity and clinical outcome of COVID-19 infections among unvaccinated and vaccinated health-care workers (HCWs).

Methods:

This was a hospital-based retrospective cohort study including all HCWs who developed microbiologically confirmed COVID-19 over 6 months from January 31, 2021, to July 31, 2021 (during the second wave of COVID-19 in India). Data were recorded through a questionnaire which included demographic details, primary location of work, history of vaccination with dates, comorbidities, severity of COVID-19, and outcome. HCWs who tested positive for SARS-CoV-2 before any dose of the COVID-19 vaccine were included in the “unvaccinated” group. Whereas HCWs who developed SARS-CoV-2 after a single or both doses of vaccine were included in the vaccinated group. The outcome and mortality among the vaccinated and unvaccinated groups were evaluated and compared.

Results:

The study included 500 HCWs who developed a microbiologically confirmed CVOID-19 infection. It was a predominantly middle-aged population with 247 unvaccinated and 253 vaccinated at the time of developing COVID-19. Only one-fourth of the population (26%) was working in the COVID-19 area and the source of COVID-19 to most was either a COVID-19 patient (39%) or a colleague (38%). Around 13% of the population had comorbidities with cardiovascular disease and diabetes being the most common. The majority of the patients were mild (71%) and most were treated at home in isolation (91%). Only 4% of the study population required intensive care. Among the vaccinated group, COVID-19 infection was predominantly mild and this difference was statistically significant as compared to the nonvaccinated. No difference was found in mortality among the two groups; however, the overall mortality was only 1%.

Conclusions:

SARS-CoV-2 vaccines reduce the severity of COVID-19 besides preventing infections and its spread. This can help in effective care of COVID-19 in home isolation without overburdening the health-care services. More studies including clinical parameters and microbiological components are required to understand the true extent of this protection of vaccines from severe forms of COVID-19.
Clinical Pharmacist Core Competencies in Saudi Arabia
Authors: Badreldin Hisham A , Aldemerdash Ahmed , Aljuhani Ohoud , Joharji Hala , Al-Omari Bedor A , Korayem Ghazwa B , Eljaaly Khalid , Almudaiheem Hajer Y , Alawagi Mohammad , Al-Mowaina Sahar M , Albekairy Abdulkareem M , Al-Jedai Ahmed
Published: October 2022

The Saudi Society of Clinical Pharmacy (SSCP) is striving to enhance the concept of clinical pharmacy within Saudi Arabia (SA) at all levels. Given the differences that exist between clinical pharmacy education, training, and practice settings in SA and other countries, the SSCP believes that it can play a proactive role in highlighting and streamlining various aspects of clinical pharmacy in SA. By gaining new knowledge, skills, and values through entering clinical practice, clinical pharmacists should be equipped with certain competencies to meet the expectations of the SSCP clinical pharmacy definition. In 2019, the SSCP established an expert writing task force of clinical pharmacy specialists representing different private and governmental sectors to lead and write a series of position statements relating to clinical pharmacy within SA. This position statement seek to identify the core competencies of clinical pharmacists in SA. The SSCP is calling on all educational institutions, postgraduate training programs, and professional organizations to collaborate to guarantee that these competencies are adopted to ensure the professional growth of clinical pharmacists and that optimal individual and population health outcomes are achieved.
Efficacy and Predictors to Response of Octreotide and Midodrine Combination in Patients with Hepatorenal Syndrome
Authors: Alabdulkarim Zinah , Alkortas Dalal , Alsebayel Mohammed Ibrahim , Alkhail Faisal Aba , Elsiesy Hussien , Al-Jedai Ahmed
Published: October 2022

Background:

Hepatorenal syndrome (HRS) is a functional form of acute kidney injury (AKI) that develops in patients with advanced liver disease. The use of octreotide (OCT) and midodrine (MID) along with albumin is commonly used in practice despite lack of strong evidence.

Objective:

The purpose of the study is to evaluate the efficacy of combining octreotide and midodrine in HRS patients.

Materials and Methods:

This is a retrospective, single center study. All patients who received both OCT/MID from January 2005 to April 2013 were identified from the electronic pharmacy system at a major tertiary care center in Riyadh, Saudi Arabia. The aim of the study is to evaluate the safety and efficacy and predictors to response of the combination of OCT/MID in patients with decompensated liver cirrhosis with type I HRS receiving standard of care therapy. The primary endpoint was the change in estimated glomerular filtration rate (eGFR) within 30 days of starting therapy compared to baseline.

Results:

There was no significant improvement in eGFR using Cockcroft-Gault (CG) from baseline until the end of treatment (P = 0.311).

Conclusion:

Combination therapy of octreotide and midodrine along with albumin did not improve the eGFR in patients with type 1 HRS.
The primary and secondary mineral resources of Montenegro and their mapping into the European data model
Authors:   Geological Survey of Montenegro, Podgorica, Radusinović Slobodan , Šajn Robert ,   Geological Survey of Slovenia, Ljubljana, Slovenia, Jovanović Božica ,   Geological Survey of Montenegro, Podgorica, Rokavec Duška ,   Geological Survey of Slovenia, Ljubljana, Slovenia, Hribernik Katarina ,   Geological Survey of Slovenia, Ljubljana, Slovenia, Abramović Vasilije ,   Geological Survey of Montenegro, Podgorica, Draksler Matej ,   Geological Survey of Slovenia, Ljubljana, Slovenia, Danilović Ivan ,   Geological Survey of Montenegro, Podgorica, Jovanović Mia ,   Geological Survey of Montenegro, Podgorica
Published: October 2022

Primary and secondary mineral resources are of strategic importance to the EU economy. Montenegro, as a country candidate for membership in the EU, is required to follow (and later to implement) European policies, strategies as well as initiatives, including those related to mineral resources and the mining sector. The importance of providing access to mineral raw materials in the future is recognized by the EU, as well as meeting the needs of European industry, maintaining employment and ensuring further development. Considering the overall economic situation in Montenegro, it is important to encourge the mining sector and other industries based on the use of mineral resources in making a greater contribution to the development and sustainability of society as a whole and also increase the share of national GDP. The potential for discovery and utilization of primary and secondary mineral resources in Montenegro is demonstrated. The most important metallic mineral resources are bauxite, lead and zinc, while conventional energy resources include coal (oil and gas potential has yet to be proven). In addition, there are abundant non-metallic mineral raw materials - industrial minerals and construction materials. Secondary mineral resources, especially aluminous red mud (bauxite residue), are also significant and have been the subject of research in recent years. Tailings from flotation processes at operating and abandoned lead and zinc mines might also be of interest for metal recovery. Bottom and flay ash from thermal power plants, slag from steel production, as well as marlstone and limestone from the hanging wall of coal deposits may also have potential. Waste rocks could be used particularly for secondary aggregate production. A database was developed and the most important deposits of primary and secondary mineral resources in Montenegro were mapped during the RESEERVE project. Mineral data were harmonised so as to be INSPIRE compliant. In addition, some novel geochemical exploration results of secondary mineral resources are presented.
General features of some pollymetalic ore deposits in the Republic North Macedonia
Authors:   Faculty of Natural and Technical Sciences, University “Goce Delcev” Stip, Repubic North Macedonia, Serafimovski Todor , Tasev Goran ,   Faculty of Natural and Technical Sciences, University “Goce Delcev” Stip, Repubic North Macedonia, Stafilov Trajče ,   Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss Cyril and Methodius University, Skopje, North Macedonia
Published: October 2022

The general features of several important mineral deposits of polymetallic character in the Republic of Northern Macedonia that have been actively exploited in the past are described. These include the Buchim copper mine and Sasa, Zletovo and Toranica lead-zinc mines, as well as some ore prospects that have been extensively explored for years. In addition, sites with known ore reserves, but which are not yet at the exploitation stage are presented, including Plavica, Ilovica, Kadiica, Borov Dol and others. The elaborated RIS-RESERVES program is used to affirm numerous parameters related to the definition of ore reserves in the deposits, and has now provided the opportunity for preparation of an overview which shows the major metallogenetic characteristics of the deposits with their techno-economic parameters. This approach enables affirmation of the potential of the polymetallic ore deposits in the Republic of Northern Macedonia.
Effect of Increased Doses of Three Mustard Oil and Two Tea Tree Oil Formulations on Cimbex Quadrimaculata
Authors: GÜRAL Yunus , ÖZGEN İnanç , HASSAN Errol , GÜRCAN Mehmet
Published: October 2022

In spring and summer time; the female of almond saw fly lay eggs in and on plant tissue, once the eggs hatch the young larvae start to feed on the almond leaves, causing defoliation of the trees depending of the population levels. In this study; evaluating the effects of three mustard oil and two tea tree oil formulations used against larval stages of the almond insect pest Cimbex quadrimaculata (Müller, 1766) (Hymenoptera: Cimbicidae). The five botanical formulations tested under laboratory conditions, using dipping method of 3 cm diameter almond leaves, which, were dipped five different dose and air dried before offered to the first larval stages, including negative control using only water. Feeding and mortality rates of 240 larvae in total were followed up until the end of the pupal period and recorded. It was determined that the increased dose of the formulation containing mustard oil + allylisothiocyanate monoethanolamine dissolved in non-ionic surfactants was more effective than other botanical formulations. The results of this study are important for almond organic pest management.
The Importance of Women's Self-Help Groups in Promoting Financial Inclusion in Bihar
Authors:   Assistant Professor, University of Delhi, Singh Haridarshan ,   Assistant Professor, University of Delhi, Hassan Mohd
Published: October 2022

Women's socioeconomic independence was significantly impacted by their involvement in self-help groups (SHGs). By "women's emancipation," we imply a procedure wherein women actively question traditional conventions in order to successfully advance their well-being. In Bihar state, this research attempted to tackle the issue of women's emancipation via self-help groups. Over 1 million Didis (recipients) are continually working to improve their lives by engaging with SHGs since SHGs nowadays are supporting women's capability in developing financial inclusivity, constructing community institutions, and associating with connected activities. Financing must be accessible to those required in India in order to break the pattern of deprivation and enable women to make significant contributions to the nation's inclusive progress. India's current rural credit structure doesn't meet the needs of the poorest people who want to move forward
Analysis of the Right to Participation of Children
Authors:   Ovidius University of Constanta, Romania, Gianina Chirugu
Published: October 2022

The purpose of the paper is to present the rights to participation of children and how these rights are implemented and respected. This paper is original through the research theme, which is of great relevance, this being demonstrated by the statistical data and the projects started at national level to promote the rights to participation of children. The objectives of this paper are as follows: Presentation of the main rights of children, analysis of international and national legislation on children’s participation rights, analysis of how this right of children is respected by the institutions of the world and those of our country, analysis of the implementation and observance of the right to participation of the child in the local community. The results of the research came to the following conclusions: the right to participate allows children to have a say in their lives. They give children the opportunity to express their opinions, discuss issues they consider important, and seek and receive information relevant to them.
Impact of the Covid-19 Plan on Financial Reporting and Information Disclosure Practices
Authors:   School of Economics - Vinh University, Quynh Lien Dr. Duong Thi
Published: October 2022

This study aims to review the factors affecting financial statements and information disclosure of enterprises during the COVID-19 pandemic, which are: Financial factors; Business activities; Enterprise value; Business contract; related parties. On that basis, future studies can test the research hypotheses in enterprises in Vietnam as well as in any other country in order to suggest for the State and managers to issue related policies. Financial statements and disclose information as appropriate.
The Impact of Problem Based Learning on Learning Outcomes in Nursing Students
Authors:   Teknologi Pendidikan, Universitas Negeri Surabaya, Surabaya, Indonesia, Hadi Saputro Suyatno
Published: October 2022

This study aims to determine the impact of problem-based learning on nursing student learning outcomes. The research method used is quasi-experimental by comparing the two groups, namely the group treated with problem-based learning and conventional learning. The research subjects were 7th semester nursing students, totaling 68 students who were divided into two groups, experiment with problem-based learning and control with conventional learning. Analysis of the data in this study by comparing learning outcomes in the two groups, experimental and control. The results of data analysis showed that students who were treated with problem-based learning obtained better learning outcomes compared to the control group or conventional learning. This research can be concluded that there is an impact of problem-based learning on nursing student learning outcomes
Factors Affecting Customer Perceptions of Service Quality in Rural Tourism of Bangladesh
Authors:   Assistant Professor, Department of Tourism and Hospitality Management, University of Dhaka, Bangladesh, Kabir Karabi , Uchinlayen Uchinlayen ,   Assistant Professor, Department of Tourism and Hospitality Management, University of Dhaka, Bangladesh, Nu Senkhing ,   Masters of Business Administration, Comilla University, Bangladesh
Published: October 2022

Purpose: This paper aims to investigate the perception of rural tourists regarding the present service attributes of Bangladeshi villages. Design/Methodology/Approach: This research involved a preliminary data collection of 532 respondents who visited different touristic spots of Bangladesh situated in the rural areas. The collected data further processed through factor analysis and five factors have been identified. Findings: The analysis reveals that the respondents are mostly neutral about the Cleanliness and Hygiene; Quality of Service and support from the local community. On the other hand they positively reacted about the calm and pleasant environmental condition but mostly dissatisfied about the recreational activities arranged for tourists. Practical Implications: This research will guide the managerial areas of the rural tourism development in the perspective of Bangladesh. Originality/Value: this is the first ever article focusing the overall development of service quality of rural tourism in the context of a developing county
The Current Art Combination of Platelet-Rich Plasma and Poly-D,L-Lactic Acid For Improvement of Deep Nasolabial Folds: A Case Report
Authors:   General Practitioner, Primaya Makassar Hospital, Makassar, Indonesia, Pratama Andi Muh. Octavian
Published: October 2022

Background: Platelet-rich plasma (PRP) is blood plasma containing an above baseline level of platelets and growth factors. Recently, Platelet-rich plasma (PRP) has come to the attention of aesthetic surgeons, with burgeoning new applications ranging from hair restoration to soft tissue augmentation. Injectable Poly-D,L-Lactic Acid (PDLLA) is a biostimulator rather than a traditional filler, which provides immediate volumetric improvement. Injectable PLA can produce a result comparable with Hyaluronic Acid fillers for the correction of wrinkles such as nasolabial folds, and can be a good choice for such a treatment. Methods: A Female 45 years Old with deep smile lines and fine wrinkles on cheeks. The patient was treated with injected of Poly(D,L Lactic Acid) and Platelet Rich Plasma. Poly-D,L-Lactic Acid was injected subdermal with retrograde linear thread technique and used 24-G cannula needle. After 3 weeks PDLLA Injection, PRP was injected intradermal into the whole face especially along the smile lines using a 32-G Needle at a dose of 0.05 ml at each injection site with a distance of about 0.5-1.0 cm. PRP was injected every 2 weeks for 3 months. Results: Wrinkle Severity Rating Scale was downgrading and skin quality like skin tone looks more brightening and fading hyperpigmentation. Conclusion: The combination of Poly-D,L-Lactic Acid and Platelet-Rich Plasma is effective for facial rejuvenation.
Modeling and forecasting air temperature in Tetouan (Morocco) using SARIMA model
Authors: Ayad Soufiane
Published: October 2022

Abstract

The past decades have seen a growing concern to understand the impact of climate change at global and regional levels. In particular, air temperature has been considered as a key factor in climate impact studies on agricultural, ecological, environmental and economic sectors.
In this study, a seasonal ARIMA model is developed through the use of the Box and Jenkins method (1970) to predict the long-term air temperature in the city of Tetouan.
Indeed, over the period of 1980 to 2022 from Sania Ramel station of the city of Tetouan, the monthly mean air temperature data are used to build and verify the model.
Four basic chronological steps, namely: Identification, Estimation, Validation and Prediction are established during the model development. The validity of the model is tested using the standardized residuals plots given by Box and Jenkins.
After carrying out the necessary checks, the ARIMA (1,0,0)(1,1,0)[12] model proved to be the most effective for predicting future air temperature.

Keywords: Air temperature, Time Series Forecasting, Box and Jenkins, Seasonal ARIMA.
REABILITAÇÃO PROTÉTICA COM PRÓTESE FIXA ASSOCIADA A PRÓTESE PARCIAL REMOVÍVEL: RELATO DE CASO CLÍNICO
Authors: André Batista Paulo , Conde Alexandre , Bozzeti Pigozzi Lucas , Cortina Bellan Maria , Paulus Marília
Published: October 2022

O Edentulismo parcial acomete, ainda hoje, grande parte dos indivíduos no território brasileiro e, infelizmente, essa condição traz inúmeras consequências para a saúde e bem-estar do paciente, sendo o tratamento protético de reabilitação uma solução apropriada para esses casos. Este estudo relata sobre a influência na qualidade de vida do indivíduo quando há a necessidade de reabilitação com prótese parcial fixa e prótese parcial removível, devolvendo estética, saúde e função. Este relato de caso mostra a importância na qualidade de vida do indivíduo pós reabilitação protética, recuperando a função do aparelho estomatognático e devolvendo estética. O estudo relata a experiência de uma paciente de 65 anos, residente em Caxias do Sul-RS, que procurou atendimento odontológico com queixa estética pela ausência de alguns elementos dentários em região superior. Após exame físico, clínico e de imagens, realizou-se o planejamento e posteriormente, a paciente iniciou tratamento protético reabilitador e acompanhamento adequado. O tratamento com o uso da prótese parcial fixa foi fundamental para reestabelecer os requisitos desejados de estética, saúde e função, devolvendo qualidade de vida à paciente.
Massive Breast Intraductal Papilloma Undiagnosed After Several Core Needle Biopsies: A Case Report
Authors: P Jiapaer , D Mengting , L Xiaofei , Y Minjia , J Ke , S Jiayu
Published: October 2022

Background: Patients with breast Intraductal Papilloma (IDP) and atypical ductal hyperplasia have an increased risk for breast cancer. Core Needle Biopsy (CNB) plays a significant role in inchoate diagnosis of atypical IDP. However, the standard procedure of CNB may be unable to provide definite diagnosis of a complicated large mass. This is the first report of the largest case of peripheral atypical IDP with ductal epithelial atypical hyperplasia and hemorrhage necrosis. The mass grew larger, without a clear diagnosis. Herein, we documented our recommendations for the treatment of a large breast mass. 1.2. Case Summary: A 74-year-old Chinese female had a palpable left breast mass for two years, which was enlarging in the past one month. The patient had periodic breast check-ups in a reputed hospital. However, the ultrasound examination and four CNBs of the breast mass did not provide a clear diagnosis, besides non-lactating mastitis. However the mass was finally diagnosed as an atypical IDP after intraoperative pathology. The patient recovered well after the lumpectomy. Conclusion: When obtaining the sample from cystic tissue during CNB, the needle should take the core of the mass as well as the surrounding wall of the cyst. Clear diagnosis is important for further treatment. Large breast IDP in elderly may develop into breast cancer, so we recommend that lumpectomy is necessary rather than periodic check-ups for these patient.
Study on Chamber Structure Optimization and Nozzle Aperture of Fluid Jet Polishing Tool
Authors: WANG Biao , WANG Zhenzhong , FU Zhenfeng , HUANG Xuepeng
Published: October 2022

The design of fluid jet polishing (FJP) tool is an important part of the FJP process.By studying effects of different tool chambers on flow-beam velocity and pressure,the paper determines the optimal type of polishing tool and provides the optimal design method.It studies those removal rates and shapes of removal function under different apertures by establishing FJP discrete phase model and flushing erosion model for simulation and experiment.The results show that in structure,the chamber shall be designed to be larger in diameter and shorter in length,and ensure the fluid movement direction is consistent with the nozzle discharge direction,so as to improve the quality of the flow beam.As the decrease of nozzle aperture, the removal rate increases and the proportion of low removal area in the center of M-shaped removal function decreases.Under experimental conditions,the Gaussian removal function can be obtained when the aperture is smaller than 0.25mm.This paper provides a reference for the real design of jet polishing tool structure.
Fromm's Idea of Developing “Sane Human Beings” and Its Contemporary Value
Authors: XU Mengya
Published: October 2022

The concept of creating “sane human beings” is proposed by Fromm based on his theory,combining Freud􀆳s psychoanalytic theory,and Marx􀆳s theory of human beings,as well as a thorough examination of the mental health in western capitalist society.Fromm examined human life in western capitalist society, believing that in addition to basic needs of animals,humans require creative personalities,freedom,and love,and concluding that alienation had pervaded all areas of human life in capitalist society.In response to the problem of people's existential dilemma and the alienation that exists in all aspects of society,Fromm proposed the idea that human beings need to be spiritually sane and that each person should become a sane human being.He argued that in order to develop sane human beings,it is necessary to build a sane society and thus restore people's critical thinking and creativity in all aspects.Fromm􀆳s idea of “sane human beings” is of significant reference value to contemporary education and culture.
The Limits of Atlantic Revolution: Indigenous Power, Spectres of Saint-Domingue, and the Maracaibo Conspiracy of 1799
Authors: Hylton Forrest , Durango-Loaiza Miguel
Published: October 2022

In the Maracaibo of 1799, Spanish authorities claimed to have uncovered a revolutionary plot to overthrow the Spanish monarchy and install a republic modeled on Saint-Domingue. In existing historical accounts, Spanish officials, free colored (pardo) militiamen in Maracaibo, and an Atlantic crew of sailors coming from Port-au-Prince play the leading roles. Although Spanish officials also claimed Guajiro Indians were coordinating and cooperating, they appear as peripheral actors. As Guajiros and their allies were more numerous and powerful than any non-Indian group in the area, and controlled the territory and waterways on which part of the trade with New Granada depended, we signal the centrality of indigenous patterns of trade, warfare, politics, and diplomacy to explain events in this corner of the revolutionary Atlantic. Thus, and in order to specify the limits of the Atlantic revolution, we argue for the need to study micro-histories of particular Guajiro leaders and their kinship-territorial networks, as well as Spanish officials and captains and crews of particular ships from European colonies.
Round Table (Part 1): The Apex of Biographical Intellectual History
Authors: Moses A. Dirk
Published: October 2022

In my brief commentary, I ask Douglas Irvin-Erickson, six years since his book appeared, about what comes next: namely, whether he thinks a new intellectual history of genocide needs transcend the assumption about its humanization of domestic and international affairs.
Bafa startet mit Fragebögen
Authors: Bender Hanno , Falker Gerrit-Milena
Published: October 2022

Rund zehn Wochen vor Inkrafttreten des deutschen Lieferkettengesetzes sendet die zuständige Aufsichtsbehörde umfangreiche Fragebögen an die betroffenen Unternehmen. Die Branche ist uneins, ob das sinnvoll ist oder eine weitere Mehrbelastung.
Unternehmen müssen für transparentere Lieferketten sorgen
Authors: Maasmann Julian , Omelchuk Anastasiia
Published: October 2022

Das neue Lieferkettensorgfaltspflichtengesetz erhitzt derzeit die Gemüter. Befürworter sehen in der Verordnung vor allem ein notwendiges Instrument, um Unternehmen zu nachhaltigeren Praktiken zu drängen. Andere argumentieren, dass die Rechtsprechung in der Gesellschaft keine spürbaren Veränderungen bringen wird.
Nur 10 Prozent der Gewässer sind intakt
Authors: Schaal René
Published: October 2022

Alle sechs Jahre werden in Deutschland aktuelle Planungen für die Verbesserung des Zustands der Gewässer in einer Broschüre veröffentlicht. Aktuell sind nur knapp 10 Prozent der Flüsse, Seen und Meere in gutem ökologischen Zustand.
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ DỰ PHÒNG VIÊM MỦ NỘI NHÃN SAU CHẤN THƯƠNG NHÃN CẦU HỞ CỦA DUNG DỊCH NHỎ MẮT LEVOFLOXACIN 1.5%
Authors: Lan Anh Giang , Trương Khánh Vân Thẩm
Published: October 2022

Mục tiêu: Đánh giá kết quả của kháng sinh nhỏ tại chỗ Levofloxacin 1.5% trong dự phòng viêm mủ nội nhãn sau chấn thương nhãn cầu hở. Đối tượng và phương pháp nghiên cứu: nghiên cứu mô tả tiến cứu không có nhóm chứng trên 50 mắt chấn thương nhãn cầu hở được điều trị khoa Chấn thương mắt bệnh viện Mắt Trung Ương từ 8/2021 đến 4/2022. Kết quả: Tỷ lệ giới nam/ nữ trong nghiên cứu xấp xỉ 2,6/1. Tuổi trung bình của các bệnh nhân trong nghiên cứu là 34,84±14,15 tuổi (nhỏ tuổi nhất là 3 tuổi và lớn tuổi nhất là 62 tuổi). Trong đó, 2 nhóm tuổi có tỷ lệ cao nhất là nhóm 16-45 tuổi (68%) và 46- 60 tuổi (18%). Phần lớn bệnh nhân có nghề nghiệp là lao động chân tay (70,0%). Đa số các trường hợp có hoàn cảnh chấn thương là tai nạn lao động chiếm tỷ lệ 64%, 32% là tai nạn sinh hoạt, tai nạn giao thông 4%. Tỷ lệ chấn thương mắt phải/ mắt trái là tương đương nhau 50% và 50%. Tỉ lệ viêm mủ nội nhãn sau khi dự phòng bằng kháng sinh nhỏ tại chỗ Levofloxacin 1.5% là 4,0% (2/50). Trong đó, cả 2 trường hợp có bệnh nguyên là vi khuẩn gram (+). Các yếu tố nguy cơ viêm mủ nội nhãn  sau chấn thương bao gồm dị vật nội nhãn, đục vỡ thể thủy tinh, chấn thương ở vùng nông thôn, kết hợp nhiều yếu tố nguy cơ và chấn thương ở Zone I. Yếu tố không ảnh hưởng tới tỉ lệ viêm mủ nội nhãn là kích thước vết thương và thời gian đóng vết thương. Kết luận: Sử dụng kháng sinh tra tại chỗ Levofloxacin 1.5% là biện pháp ít hiệu quả trong dự phòng viêm mủ nội nhãn sau chấn thương nhãn cầu hở.
SARCOMA MÔ MỀM THỂ HỐC: BÁO CÁO NHÂN MỘT TRƯỜNG HỢP
Authors: Duy Thanh Trần , Thị Trang Chu , Viết Trung Nguyễn , Quốc Đạt Nguyễn
Published: October 2022

Sarcoma mô mềm thể hốc (Alveolar soft part sarcoma - ASPS) được mô tả lần đầu bởi Christopherson và các cộng sự vào năm 1952, nó là một khối u ác tính hiếm gặp, theo hiểu biết của chúng tôi, 15 trường hợp di căn nội sọ đã được báo cáo, trong đó có 5 trường hợp liên quan đến màng não trong tài liệu Anglo-Saxon . Báo cáo ca bệnh: Chúng tôi báo cáo một trường hợp bệnh nhân nữ trẻ tuổi có khối u khu trú ở màng não được phẫu thuật cắt bỏ u và có chẩn đoán giải phẫu bệnh là sarcoma mô mềm thể hốc.
TÁC DỤNG KHÔNG MONG MUỐN CỦA HOÁ XẠ TRỊ TRÊN UNG THƯ BIỂU MÔ TUYẾN PHỔI GIAI ĐOẠN III BẰNG PHÁC ĐỒ CISPLATIN KẾT HỢP VỚI ETOPOSIDE HOẶC PEMETREXED
Authors: Thị Thái Hoà Nguyễn , Thế Cường Trịnh , Mai Lan Nguyễn
Published: October 2022

Hoá xạ trị đồng thời là điều trị căn bản của ung thư phổi không tế bào nhỏ giai đoạn III không mổ được. Đối với ung thư biểu mô tuyến, phác đồ hoá trị thường được áp dụng trên thực tế lâm sàng tại Bệnh viện K là Etoposide – Cisplatin (EP) hoặc Pemetrexed – Cisplatin (PeC). Mục tiêu của nghiên cứu là đánh giá tác dụng không mong muốn của hoá xạ trị đồng thời với 2 phác đồ EP và PeC. Đối tượng và phương pháp: Nghiên cứu hồi cứu đánh giá tác dụng không mong muốn của 50 bệnh nhân điều trị phác đồ Etoposide – Cisplatin (EP) và 31 bệnh nhân điều trị phác đồ Pemetrexed – Cisplatin (PeC) đồng thời với tia xạ 3D cho ung thư biểu mô tuyến phổi giai đoạn III không mổ được. Kết quả: Tỷ lệ hạ huyết sắc tố, hạ bạch cầu trung tính và hạ tiểu cầu của phác đồ EP và PeC tương ứng là 76%, 84% và 28% và 51,6%, 41,9% và 12,9%. Tỷ lệ hạ huyết sắc tố và hạ bạch cầu trung tính của phác đồ PeC thấp hơn có ý nghĩa thống kê so với EP. Tỷ lệ viêm phổi, viêm thực quản và khô da của hai phác đồ lần lượt là 22%, 66% và 62% với EP và 16,1%, 48,4% và 45,1% với PeC. Tỷ lệ mệt mỏi của phác đồ PeC 51,6% thấp hơn có ý nghĩa so với phác đồ EP là 84%. Kết luận: Phác đồ PeC có tỷ lệ mệt mỏi, hạ huyết sắc tố, hạ bạch cầu trung tính thấp hơn có ý nghĩa so với phác đồ EP
NGHIÊN CỨU XÂY DỰNG QUY TRÌNH ĐỊNH LƯỢNG QUERCETIN TRONG THỰC PHẨM BẢO VỆ SỨC KHỎE VÀ THUỐC BẰNG SẮC KÝ LỎNG HIỆU NĂNG CAO
Authors: Thị Thủy Vũ
Published: October 2022

Flavonoid là một nhóm hợp chất lớn thường gặp trong thực vật. Quercetin  là một Flavonoid, được nghiên cứu là có khả năng giảm nguy cơ mắc các bệnh về tim mạch, ngăn chặn sự phát triển của bệnh ung thư, chóng dị ứng và giảm đau cho bệnh gout… Hiện nay, Quercetin được sử dụng khá rộng rãi chủ yếu dưới dạng thực phẩm chức năng và có mặt trên thị trường dược phẩm với những dạng bào chế khác nhau: Viên nén, viên nang, dạng bột…. Hiện nay, trong các dược điển chưa thấy có chuyên luận riêng chính thức để định tính và định lượng quercetin. Vì vậy, để nâng cao hiệu quả công tác giám sát chất lượng thuốc phục vụ sức khỏe cộng đồng, nhóm nghiên cứu đã tiến hành đề tài  Mục tiêu: Nghiên cứu xây dựng quy trình định lượng Quercetin trong TPBVSK và thuốc có nguồn gốc từ dược và áp dụng quy trình đã xây dựng để định lượng Quercetin trong một số sản phẩm hiện đang lưu hành trên địa bàn tỉnh Hà Tĩnh. Đối tượng và phương pháp nghiên cứu: Một số thực phẩm bảo vệ sử khỏe và thuốc có nguồn gốc từ dược liệu  thu thập trên địa trên địa bàn tỉnh Hà Tĩnh. Tiến hành xác định Quercetin bằng phương pháp sắc ký lỏng hiệu năng cao. Kết quả: Đã xây dựng được quy trình định lượng quercetin bằng phương pháp sắc ký lỏng hiệu năng cao. Quy trình phân tích được kiểm soát chất lượng và đạt độ lặp lại cao với RSD < 2,0% (n = 9); đạt độ đúng tốt với độ thu hồi từ 103,9% - 119,6%. Đã áp dụng thành công quy trình xây dựng để phân tích quercetin trong 4 mẫu gồm thuốc Đông dược và TPBVSK đang lưu hành trên thị trường tỉnh Hà Tĩnh. Kết luận: Xây dựng quy trình định lượng hàm lượng quercetin có trong thực phẩm bảo vệ sức khỏe, thuốc có nguồn gốc dược liệu.
RỐI LOẠN NUỐT VÀ MỘT SỐ YẾU TỔ LIÊN QUAN TRÊN BỆNH NHÂN PARKINSON GIAI ĐOẠN MUỘN
Authors: Thị Thuỳ Linh Nguyễn , Thị Kim Liên Nguyễn , Thanh Bình Nguyễn
Published: October 2022

Bệnh Parkinson là một bệnh lí thoái hoá thần kinh trung ương thường gặp ở người cao tuổi, đặc trưng bới sự kết hợp triệu chứng vận động và ngoài vận động. Rối loạn nuốt là vấn đề thường gặp ở bệnh Parkinson đặc biệt trong giai đoạn muộn. Điều này gây ảnh hưởng trực tiếp đến lượng dinh dưỡng người bệnh đưa vào cơ thể cũng như việc chuyển hoá và có tác dụng của thuốc điều trị, làm tăng nguy cơ bị viêm phổi sặc (Aspiration pneumonia) đe dọa tính mạng người bệnh. Mục tiêu: Mô tả đặc điểm rối loạn nuốt và phân tích một số yếu tố liên quan đến rối loạn nuốt ở người bệnh Parkinson giai đoạn muộn tại Bệnh viện Lão khoa Trung ương từ tháng 8 năm 2021 đến tháng 6 năm 2022. Phương pháp: Đặc điểm rối loạn nuốt được đánh giá theo đặc điểm lâm sàng, thang Tầm soát Nuốt theo Gugging (GUSS). Kết quả: Tuổi trung bình của nhóm nghiên cứu là: 71,22 ± 8,61 tuổi, tuổi chủ yếu > 60 tuổi, tỷ lệ nam: nữ: 1,58:1. Thời gian mắc bệnh trung bình là 6,80 ± 4,13 năm. Biểu hiện rối loạn nuốt hay gặp nhất là thay đổi giọng nói và nuốt vướng. Các biến chứng thường gặp bao gồm: thay đổi thói quen ăn uống, suy dinh dưỡng và viêm phổi. Bệnh nhân có triệu chứng vận động nặng hơn (điểm UPDRS phần III cao hơn), thời gian mắc bệnh lâu hơn, có điểm GUSS thấp hơn. Kết luận: Trong nghiên cứu của chúng tôi, rối loạn nuốt ở bệnh nhân Parkinson hay biểu hiện là thay đổi giọng nói và nuốt vướng. Biến chứng thường gặp là thay đổi thói quen ăn uống và suy dinh dưỡng. Bệnh nhân có càng nhiều triệu chứng vận động và thời gian mắc bệnh kéo dài thì điểm GUSS càng thấp, tương ứng với mức độ rối loạn nuốt nặng hơn.
GIÁ TRỊ BIÊN ĐỘ PHỨC BỘ QRS TẠI THỜI ĐIỂM 40 MS KHỞI ĐẦU Ở CHUYỂN ĐẠO V2 (V2QRSI40) TRONG DỰ ĐOÁN VỊ TRÍ RỐI LOẠN NHỊP THẤT TỪ ĐƯỜNG RA TÂM THẤT
Authors: Tuấn Việt Nguyễn , Tuấn Việt Trần , Duy Linh Nguyễn , Đình Phong Phan
Published: October 2022

Mục tiêu: Xác định giá trị biên độ sóng tại thời điểm 40 ms khởi đầu ở chuyển đạo V2 (V2QRS i40 ms) trong chẩn đoán vị trí khởi phát rối loạn nhịp thất từ đường ra các tâm thất.  Phương pháp nghiên cứu: Nghiên cứu thực hiện trên 84 bệnh nhân được chẩn đoán xác định và triệt đốt rối loạn nhịp thành công tại đường ra thất phải (nhóm RVOT)  (n = 68) và đường ra thất trái (nhóm LVOT) (n = 16). Biên độ sóng trong 40 ms khởi đầu của phức bộ QRS (V2QRSi40) được đo bằng hệ thống thăm dò điện sinh lý tim. Kết quả: Giá trị QRSi40 trên các chuyển đạo trước tim không có khác biệt giữa hai nhóm rối loạn nhịp từ đường ra thất phải (nhóm RVOT) và đường ra thất trái (nhóm LVOT) ngoại trừ V2QRSi40. Chỉ số V2QRSi40 có diện tích dưới đường cong ROC (AUC) là lớn nhất (0.882) với ngưỡng cut-off ≥ 0.535 mV có giá trị dự đoán vị trí khởi phát rối loạn nhịp từ LVOT (độ nhạy 87.5% và độ đặc hiệu 89.7%). Giá trị V2QRSi40 vượt trội hơn chỉ số V2S/V3R và TZ index và tương đương với chỉ số V2 transition ratio (với AUC = 0.949).  Kết luận: V2QRSi40 là một tiêu chuẩn có giá trị trong dự đoán vị trí khởi phát rối loạn nhịp từ đường ra các tâm thất.