bluuebunny/crossref_metadata_2025 huggingface dataset:
Respons Pertumbuhan Tanaman Anggrek Dendrobium (Dendrobium sp.) Terhadap Pemberian Monosodium Glutamate (MSG) pada Media Sabut Kelapa
Authors: Nurfadillah To Kau  , Suhaeni Suhaeni , Sacita Andi Safitri
Published: October 2022

Anggrek dendrobium merupakan salah satu jenis anggrek yang memiliki daya tarik dan paling banyak diminati masyarakat diantara jenis anggrek lainnya. Sementara itu, anggrek ini merupakan tanaman dengan pertumbuhan yang cukup lambat, namun permintaan terus menerus meningkat setiap tahunnya. Pertumbuhan tanaman anggrek yang lambat dapat dipacu dengan aplikasi  Zat Pengatur Tumbuh (ZPT). Penelitian ini bertujuan untuk mengetahui pengaruh serta konsentrasi terbaik dari pemberian Monosodium Glutamate (MSG) sebagai Zat Pengatur Tumbuh  pada media sabut kelapa yang mampu merangsang pertumbuhan tanaman anggrek dendrobium. Penelitian ini dilaksanakan di Rumah Anggrek Fakultas Pertanian UNCP pada Bulan Maret – Mei tahun 2022. Penelitian ini menggunakan metode Rancangan Acak Kelompok (RAK) dengan 4 perlakuan dan 3 ulangan sehingga dalam penelitian ini terdapat 12 unit percobaan. Adapun perlakuan yang diberikan yaitu, P0 : Tanpa perlakuan, P1 : MSG 7,5 gram/liter air, P2 : MSG 10 gram/liter air, P3 : MSG 12,5 gram/liter air. Hasil penelitian menunjukkan bahwa pemberian perlakuan MSG memberikan pengaruh yang berbeda sangat nyata terhadap tinggi tanaman, jumlah daun, dan jumlah anakan tanaman anggrek dendrobium. Perlakuan terbaik ditunjukkan oleh P3 dengan rata-rata tinggi tanaman 16,20 cm, rata-rata jumlah daun 17,67 helai, dan rata-rata jumlah anakan 4.

Dendrobium orchids are one of the most attractive types of orchids and are in great demand by the public among other types of orchids. Meanwhile, this orchid is a plant with a fairly slow growth, but the demand continues to increase every year. The slow growth of orchid plants can be stimulated by the application of Growth Regulators (ZPT). This study aims to determine the effect and the best concentration of monosodium glutamate (MSG) as a growth regulator on coconut fiber media which can stimulate the growth of dendrobium orchids. This research was conducted at the Orchid Farm, Faculty of Agriculture, UNCP in March – May 2022. This study used a Randomized Block Design (RAK) method with 4 treatments and 3 replications so that in this study there were 12 experimental units. The treatments given were, P0: No treatment, P1: MSG 7.5 grams/liter of water, P2: MSG 10 grams/liter of water, P3: MSG 12.5 grams/liter of water. The results showed that the MSG treatment gave significantly different effects on plant height, number of leaves, and number of tillers of dendrobium orchids. The best treatment was shown by P3 with an average height plant 16.20 cm, an average number of leaves 17.67, and an average number of tillers 4.
Gender characteristics of patients with arterial hypertension
Authors: Sapunova D. A. , Kachenkova E. S. , Medvedev I. N.
Published: October 2022

Despite the prevalence of arterial hypertension among both sexes, there are data on the presence of gender diff erences in its formation and course.

The purpose of the study: to identify gender characteristics in the clinical and biochemical status of patients suff ering from stage 1 and 2 of arterial hypertension.

Material and methods. 80 patients of the second mature age with confi rmed arterial hypertension were examined. The patients were divided into 2 groups: the fi rst group consisted of 44 patients with stage 1 arterial hypertension (11 men and 33 women), the second group consisted of 36 patients with stage 2 disease (25 men and 11 women). All patients underwent a biochemical blood test; the glomerular fi ltration rate, the thickness of the Intima-media complex of the common carotid artery with the processing of the results by the Smirnov–Kolmogorov test were determined.

Results. With the stage I arterial hypertension in both sexes, the level of blood pressure was corresponding to it. With stage II, the blood pressure in men corresponded to the level of the 1st stage, and in women to the level of the 2nd stage arterial hypertension. The level of total cholesterol and low-density lipoprotein cholesterol in all cases exceeded the normal level, prevailing in both groups in women. This was accompanied by an imbalance in the levels of thromboxane B2 and 6-ketoprostaglandin F1α at stage I hypertension, which was more pronounced in women and increased with the higher stage of the disease. The glomerular fi ltration rate in men of both groups was intact. In women, it was reduced at the onset of the disease, and kept decreasing at stage II. The width of the intima-media complex in women prevailed over this indicator in men at stage I and further increased at stage II.

Conclusion. From the start of the development of arterial hypertension, women have had more pronounced and faster progressive lipid, hemostatic, renal and sclerotic changes compared to men.
Diffi culties in diff erential diagnosis of the etiology of STEMI in the early postpartum period
Authors: Tavlueva E. V. , Markarov A. E. , Gromov D. G. , Veretennikova A. V. , Ivanova A. A. , Konik V. A. , Berns S. A.
Published: October 2022

Objective. A clinical case of a 38-year-old female patient with STEMI in the early postpartum period describes the complex issues of diff erential diagnosis with imaging methods application.

Results. During the patient’s fi rst hospitalization with STEMI, additional intravascular imaging techniques such as intracoronary ultrasound and/or optical coherence tomography, could help to determine the nature and signifi cance of the coronary lesion. Due to the inability to perform IVUS and OCT, we performed a coronary angiography. According to the results, there were no obvious signs of coronary dissection. Using additional intravascular imaging techniques, we might have obtained diff erent results and would have chosen a diff erent tactic of treatment.

Conclusion. The case described indicates the need for a comprehensive diagnosis of MI in women in the postpartum period.
TINGKAT PEMAHAMAN DAN BENTUK PERILAKU MENDUKUNG KELUARGA PENDERITA SKIZOFRENIA
Authors: Imanti Vera , Rumbi Nia
Published: October 2022

Tujuan dari penelitian ini adalah mengetahui tingkat pemahaman tentang gangguan jiwa pada caregiver dan mengetahui perilaku mendukung keluarga pada penderita skizofrenia di Griya Peduli PMI Surakarta. Subjek pada penelitian ini sebanyak 22 caregiver yang mempunyai anggota keluarga dengan skizofrenia. Metode penelitian yang digunakan pada penelitian ini adalah metode mix methods atau metode penelitian kombinasi, yang berarti mengkombinasikan antara metode kuantitatif dan metode kualitatif. Pada penelitian ini menggunakan jenis sequential explanatory design, dimana pengumpulan data dan analisis data kuantitatif pada tahap pertama, diikuti dengan pengumpulan data dan analisis data kualitatif pada tahap kedua. Hasil penelitian menunjukkan bahwa pemahaman tentang gangguan jiwa pada caregiver terbagi menjadi 4 kategori, dimana 5 responden masuk kategori rendah, 11 responden dengan masuk dalam kategori sedang, 4 responden masuk dalam kategori tinggi, dan 2 responden masuk dalam kategori sangat tinggi. Hasil perhitungan dari setiap aspek pemahaman, dengan aspek tahu mendapatkan nilai 70%, aspek paham dengan nilai 70%, aspek aplikasi 76%, aspek analisa 67%, aspek sintesis 68%, dan aspek evaluasi mendapatkan nilai 65%. Data kualitatif yang didapat memperkuat dan memperdalam data dari hasil kuantitatif.
HUBUNGAN ANTARA KEPEMIMPINAN TRANSFORMASIONAL DAN LEADER-MEMBER EXCHANGE TERHADAP KOMITMEN ORGANISASI PADA KARYAWAN GENERASI Y
Authors: Wahidah Safinatul
Published: October 2022

Penelitian ini bertujuan menguji pengaruh kepemimpinan transformasional dan leader-member exchange pada karyawan generasi Y. Pengambilan sampel dilakukan dengan menggunakan teknin non-probability sampling. Jumlah sampel penelitian adalah 3 orang dengan karakteristik PNS di BP2MI yang lahir dalam rentang tahun 1980 – 2000. Metode pengumpulan data menggunakan Multifactor Leadership Questionnaire, Leader Member Exchange – Multi Dimensional Measures, dan  Skala Komitmen Organisasi. Pengujian hipotesis dilakukan dengan menggunakan teknin analisis regresi ganda dengan hasil penelitian yang menunjukkan bahwa terdapat pengaruh antara kepemimpinan transformasional dan leader-member exchange terhadap komitmen organisasi. Sumbangan simultan pengaruh kedua variabel terhadap komitmen organisasi adalah 56,3 %. Sumbangan partial kepemimpinan transformasional dan leader-member exchange terhadap komitmen organisasi masing-masing adalah 15,7 %, dan 40,6 %. Kesimpulan dari penelitian ini adalah bahwa kepemimpinan transformasional dan leader-member exchange dapat memprediksi tingkat komitmen organisasi karyawan generasi Y, dan pengaruh yang diberikan leader-member exchange lebih besar daripada pengaruh kepemimpinan transformasional.
FAKTOR-FAKTOR YANG MEMENGARUHI RESILIENSI REMAJA DI MASA PANDEMI
Authors: Hertinjung Wisnu Sri , Yuwono Susatyo , Partini Partini , Laksita Andira Koza , Ramandani Annisa Ayu , Kencana Shafira Sekar
Published: October 2022

Penelitian ini bertujuan untuk menguji korelasi regulasi emosi, optimisme, dan dukungan keluarga  dengan  resiliensi siswa pada masa pandemi Covid-19. Faktor internal siswa berupa kemampuan mengelola emosi dan rasa optimis menghadapi situasi yang sulit dan memerlukan penyesuaian tinggi, serta faktor eksternal berupa dukungan keluarga, akan menumbuhkan jiwa resilien berupa ketangguhan menghadapi kesulitan dan tidak mudah menyerah. Hipotesis mayor yang diajukan terdapat hubungan antara  regulasi emosi, optimisme, dan dukungan keluarga dengan resiliensi. Terdapat 3 hipotesis minor, yaitu adanya hubungan positif antara regulasi emosi dengan resiliensi; hubungan positif antara optimisme dengan resiliensi; dan hubungan positif antara dukungan keluarga dengan resiliensi. Metode penelitian yang digunakan adalah kuantitatif korelasional. Pengumpulan data dilakukan dengan menggunakan skala regulasi emosi, skala optimisme, skala dukungan keluarga, dan skala resiliensi.  Populasi dalam penelitian  ini adalah siswa SMA dan SMK di Sukoharjo. Pemilihan subjek penelitian dengan teknik simple random sampling. Teknik analisis yang digunakan adalah uji korelasi regresi berganda. Hasil penelitian adalah terdapat hubungan yang sangat signifikan antara regulasi emosi, optimisme, dan dukungan keluarga dengan resiliensi siswa (F=47,561; p<0,001). Uji hipotesis minor 1 diperoleh hasil r=0,607; p<0,001 artinya terdapat hubungan positif yang sangat signifikan antara regulasi emosi dengan resiliensi, untuk variabel optimisme diperoleh nilai r=0,585;p<0,001 dan dapat dinyatakan terdapat korelasi positif yang sangat signifikan antara optimism dengan resiliensi, variabel dukungan keluarga menunjukan hasil r=0,431;p<0,001, sehingga dapat dinyatakan bahwa terdapat hubungan positif yang sangat signifikan antara variabel dukungan keluarga dengan resiliensi. Dapat disimpulkan bahwa hipotesis penelitian yang diajukan seluruhnya terbuktiAbstrak harus dibuat dalam bahasa Indonesia dan dalam bahasa Inggris.
MAKNA KOMITMEN BAGI GURU HONORER SEKOLAH DASAR
Authors: Anugrah Rahma , Daud Muhammad , Hamid Andi Nasrawati
Published: October 2022

Guru honorer yang berkomitmen meskipun dengan pendapatan yang rendah, ketidakpastian status pengangkatan dan kondisi kerja yang belum memadai, memiliki keberagaman arti dalam memaknai komitmen, yang berpengaruh terhadap perilaku kerja guru. Tujuan penelitian ini yaitu memahami makna komitmen yang dimiliki guru honorer. Penelitian ini menggunakan pendekatan interpretative phenomenological analysis. Pengambilan data menggunakan wawancara semi terstruktur kepada lima guru honorer dengan masa kerja tujuh hingga 14 tahun. Hasil analisis data menunjukkan bahwa komitmen dimaknai sebagai bentuk adanya harapan menjadi aparatur sipil negara, upaya mempertahankan pekerjaan, bentuk pengabdian, dan  sebagai wujud rasa cinta terhadap sekolah. Faktor positif memengaruhi keputusan guru untuk bertahan, namun faktor negatif tidak sampai memengaruhi keputusan bertahan, namun memengaruhi perilaku kerja guru. Berbagai makna komitmen menghasilkan beragam komponen komitmen, yang berpengaruh terhadap perilaku kerja guru. Guru yang memaknai komitmen sebagai wujud rasa cinta dan bentuk pengabdian umumnya melakukan usaha lebih dalam bekerja. Penelitian ini memberikan gambaran makna komitmen dan dampaknya terhadap perilaku kerja guru, sehingga dapat menjadi acuan bagi guru honorer dalam mempertahankan komitmen yang dimiliki, dan menjadi acuan bagi pihak sekolah serta dinas pendidikan dalam memerhatikan faktor yang meningkatkan komitmen guru. Kata kunci : Guru honorer, Komitmen organisasi, Sekolah
Penerapan Metode DMAIC untuk Mengurangi Cacat Hasil Pengelasan Di PT.X
Authors: Bachtiar Onny Ardhi , Widodo Silvi Rushanti , Tripariyanto Afiff Yudha
Published: October 2022

One of the most important components in the boiler is piping. The piping is the flow of water vapor to the area used for energy conversion. If the piping condition is not good, or in a defective condition will negatively affect the flow of water to be converted into steam. The boiler construction process, in general, can be completed within 2 years. But a common problem is the occurrence of damaged conditions in piping. This study aims to find out the improvement efforts to reduce the defects of welding results in boiler Machine piping using the DMAIC method. The method identifies problems, follows the occurrence of problems, provides analysis to be developed and Controlled. The results of this study explain the Machine aspect that is monitoring the time of use and using the rules on the welding Machine so that there is no more damage; aspects of methods, man, Measurement and management do the agenda at the end of each month and continue to improve the motivation of work; and the material aspect that the supplier sends evidence of materials that are ready to send to Improve the quality of pipes - pipes to be used.Â Salah satu komponen dalam boiler paling penting adalah perpipaan. Perpipaan tersebut sebagai jalannya aliran uap air menuju area yang digunakan untuk konversi energi. Jika kondisi perpipaan tidak baik, atau dalam kondisi cacat akan memberikan pengaruh negatif pada jalannya aliran air untuk dikonversi menjadi uap. Proses pembangunan boiler secara umum dapat selesai dalam kurun waktu 2 tahun. Tetapi masalah yang sering dijumpai adalah terjadinya kondisi rusak pada perpipaan. Penelitian ini bertujuan untuk mengetahui upaya perbaikan untuk mengurangi kecacatan hasil pengelasan pada perpipaan mesin boiler menggunakan metode DMAIC. Metode tersebut mengidentifikasi masalah, mengikut kejadian masalah, memberikan analisis untuk dikembangkan dan dikendalikan. Hasil penelitian ini menjelaskan aspek Machine yaitu memantau waktu penggunaan dan menggunakan secara aturan pada mesin las agar tidak terjadi kerusakan lagi; aspek method, man, Measurement dan management melakukan agenda setiap akhir bulan dan kontinu untuk meningkatkan motivasi kerja; dan aspek material yaitu pihak supplier mengirim bukti material yang siap kirim untuk meningkatkan mutu pipa â€“ pipa yang akan digunakan.Â
On the Main Terms of the Forensic Psychological Analysis of Information Materials
Authors: Sekerazh T. N.
Published: October 2022

The article presents the results of the development of the main terms of the forensic psychological analysis of information materials. At the current stage the author suggests the definitions of twelve terms, including the subject of this type of examination, its object, tasks, and methods. She also defines “information materials” as a collective, generalized concept of the forensic psychological analysis of information materials. It is shown that the new direction of forensic psychology is a continuation of its traditional areas related to the study of living persons and post-mortem (absentee) studies, as well as the reliance on the forensic expertology is justified.

The article is the first in the series of works on the unification of the terms and definitions of the forensic psychological analysis of information materials. The author invites the expert community to a discussion to develop the most correct definitions of the main terms of this type of examination for their subsequent standardization.
Normative Regulation for the Application of Specialized Knowledge in Civil Proceedings
Authors: D’yakonova O. G.
Published: October 2022

Based on the analysis of use of specialized knowledge in legal proceedings, the author reveales its common forms and types applied in civil and administrative proceedings. The problems and conflicts generated by the legal regulation of the use of specialized knowledge in legal proceedings have also been reviewed. As a result, the author concludes that there is no unified approach to the legal regulation of forensic expertise and the participation of a specialist in civil and administrative proceedings.

 Practically there arise some problems associated both with the appointment and production of a forensic examination, and with the participation of a specialist in procedural actions.

The inability to resolve certain issues results in the recognition of evidence as inadmissible. One of the main reasons for this is the adoption of procedural codes and amendments and additions to them without considering the provisions developed by the science of forensic expertology. The author emphasizes that forensic expertology studies legal, including normative, theoretical, and methodological issues of the use of specialized knowledge in legal proceedings basing on the integrated approach, and so it does not monopolize the subject of research, but provides a versatile approach to it, considering the developments of procedural sciences. As a result, forensic expertology can act as the fundamental knowledge for normative regulation and implementation of legal institutions of forensic expertise and participation of a specialist.
HISTOPATOLOGI PANKREAS TIKUS (Rattus norvegicus) DIABETES MELITUS YANG DIBERI EKSTRAK ETANOL BAWANG BATAK (Allium chinense G.Don)
Authors: Butar-Butar Tri Novitashari , Ferbriani Husnarika , Rasyidah Rasyidah , Syukriah Syukriah
Published: October 2022

Diabetes mellitus occurs due to insulin resistance and disruption of insulin secretion. Bawang Batak (Allium chinense G.Don) is a herbal plant that is often used by the community as a traditional medicine for the treatment of diabetes mellitus, but there have been no preclinical studies. This study aims to determine the effect of bawang batak extract on the histopathology of the pancreas of alloxan-induced diabetes mellitus rats. This study used rats as experimental animals which were divided into 6 groups (normal control, negative control, metformin group, P1:bawang batak extract dose 250 mg/kg, P2:500 mg/kg, and P3:750 mg/kg), with 4 repetitions. The histological preparations of pancreas were made using the paraffin method with hematoxylin-eosin staining. Data were analyzed using one-way ANOVA and Duncan's test. The statistical results showed that there was a significant difference (p <0.05) in the diameter and area of islet langerhans between the control group and the treatment group. The diameter and area of islet Langerhans improved when compared to the negative control group. It can be concluded that the onion extract has an effect on the improvement of pancreatic in rats with diabetes mellitus and the most effective dose of bawang batak extract is 500 mg/kg.
Inventarisasi Jenis dan Potensi Tumbuhan Marga Elatostema, Pilea, dan Dendrocnide di Hutan Primer Desa Bukum
Authors: Idami Zahratul , Hutasuhut Melfa Aisyah , Ramayati Ike
Published: October 2022

Plants of Elatostema, Pilea, and Dendrocnide genus are members of the Urticacea family that are scattered in the forest, one of which is found in the Primery Forest of Bukum Village, Sibolangit. The purpose of this study was to find out what types of plants from the genera Elatostema, Pilea and Dendrocnide live in the Forest of Bukum Village, and identify the potential use of these plants. This research method is an exploratory survey. The plant inventory was obtained using a 10m x 10m plot placed by purposive sampling. While the potential use of the use of research journal literature techniques. The results of this study obtained 8 species of the Elatostema genus, 3 species of the Pilea genus, and 2 species of the Dendrocnide genus. The literature study shows 5 potential uses of each type of plant studied from the three genera of the Urticacea family, namely wood producers, medicinal plants, fruits, vegetable producers, and animal feed
Spiritualitas egalitarian dalam pendidikan kristiani
Authors: Sirait Jannes Eduard
Published: October 2022

Latar belakang penelitian ini adalah ketidakmampuan pemerintah mewujudkan kesetaraan pendidikan bagi warga negara Indonesia, termasuk akses dan kualitasnya. Tujuan penelitian ini adalah untuk menganalisis kesetaraan pendidikan dari perspektif kristiani. Fokus penelitian ini berada pada percakapan dan analisis kesetaraan pendidikan. Harapannya, hasil riset ini dapat menjadi refleksi bagi institusi pendidikan Kristen untuk memikirkan kesetaraan pendidikan bagi warga gereja dan masyarakat pada umumnya. Penelitian ini memakai metode deskriptif kualitatif dengan pendekatan pemikiran filosofis-teologis Kristiani. Penelitian ini melakukan studi literatur dengan pengumpulan informasi yang relevan. Hasil penelitian memperlihatkan kendala terwujudnya kesetaraan pendidikan, yaitu adanya komersialisasi pendidikan, sulitnya mencari donatur yang dermawan untuk pendidikan, rendahnya mutu sumber daya manusia dan faktor ekonomi masyarakat. Supaya dapat mewujudkan kesetaraan pendidikan tersebut maka pendidikan perlu mendapat sokongan gereja, lembaga pendidikan, melakukan pemberdayaan bagi masyarakat dan meningkatkan mutu paraktisi pendidik serta menyelenggarakan pendidikan alternatif.
Development of Christian religious education learning model based on the philosophy of orang basudara life in Maluku
Authors: Pattinama Eklefina , Salenussa Beatrix J.M.
Published: October 2022

Knowledge of the concept of the basudara in Moluccas is generally understood by adults only. Among young people, the concept of the basudara person becomes foreign. The impact of the loss of the concept of the basudara philosophy among young people in Ambon City, Latta Village, often occurs in brawls between teenagers of different ethics and religions who live side by side. It is a threat to building peace and can create new conflicts. The teachers need to develop a model of Christian Religious Education for peace based on the philosophy of the Basudara people in the Moluccas. This study aims to develop a learning model for Christian Religious Education for Peace based on the philosophy of life of the Basudara people in the Moluccas. The learning model is made in the form of textbooks (textbooks) that can be used as a source of student learning to develop the character of life as a peaceful, compassionate person regardless of conflicts in the family, community, or church environment. The research method used is development research using the ADDIE learning model (Analysis-Design-Develop-Implement-Evaluate), with the aim of this research being the youth-level Sunday school students at the Moluccas Protestant Church, the Latta Congregation. The results of this study indicate that the development of the Peaceful Christian Religious Education Learning model based on the Basudara people's philosophy - of life in the Moluccas - is needed by Sunday School students. It is learning materials based on local content that can be used as relevant teaching materials. an effective cultural instrument in revitalizing and transforming peace in the context of the Church, which is contextually adapted to the philosophical values of local cultural wisdom in the Moluccas. Thus, it is concluded that with the teaching materials used, students can apply how to live peacefully side by side in a multicultural context.
A Systematic Review of the Literature on Inservice Professional Development Explicitly Addressing Race and Racism
Authors: Matschiner Andrew
Published: October 2022

This systematic literature review examines research on U.S. professional development (PD) in which practicing teachers are asked to engage explicitly with race and racism. Using Kennedy’s PD theories of action, this review examines 64 studies published from 1981 to 2019 and analyzes race-related PD goals, pedagogical approaches, and documented outcomes of PD. The body of scholarship shows an array of PD program goals, often-limited pedagogical explicitness and detail, and descriptive and developmental outcomes. Recent scholarship has centered racial-equity-oriented teachers and teachers of Color and identified PD characteristics associated with positive outcomes. Extant literature has seldom directly documented PD transfer and incorporation in schools or documented PD impact on students. Areas for future research include further leveraging scholarship on change processes including teacher learning and PD effectiveness, documenting teacher development beyond PD sessions, probing affordances of different PD settings and formats, and examining how PD ultimately impacts student experience.
Impact of Spermatozoa Cryopreservation on Clinical Outcomes of Intracytoplasmic Sperm Injection in Patients with Azoospermia: A Retrospective Cross-Sectional Study
Authors: Wang Yali , Chen Dongjia , Cai Bing , Huang Dan , Xu Yanwen , Ding Chenhui
Published: October 2022

Background: This study was undertaken to evaluate the effect of cryopreservation on the clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles using sperm retrieved from testicular sperm extraction (TESE) in patients with azoospermia. Methods: This retrospective analysis included the clinical data of 56 pairs of fresh and frozen sperm injection cycles from 56 couples after TESE from January 2019 to December 2021 at the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-sen University, of which 42 pairs were ICSI cycles using fresh and frozen sperm from the same TESE procedure. We compared the embryological and laboratory characteristics and pregnancy outcomes of the subsequent first embryo transfer (ET) cycles between the fresh and frozen groups. Results: There were no significant differences in the fertilization, cleavage, good-quality day 3 embryo, blastocyst formation, and good-quality blastocyst rates between the groups. However, when only paired ICSI cycles of fresh and frozen sperm from the same TESE procedure were analyzed, we observed that the good-quality day 3 embryo rate (44.8% vs 33.2%, p = 0.029) and blastocyst formation rate (57.5% vs 41.3%, p = 0.028) in the fresh group were significantly higher than those in the frozen group. Implantation, clinical pregnancy, early miscarriage, and live birth rates of the first ET cycle were not significantly different in either group. Conclusions: ICSI using fresh testicular sperm after TESE in patients with azoospermia appears to yield better embryological and laboratory outcomes than ICSI using cryopreserved testicular sperm, but the success rate of the subsequent first ET cycles does not seem to be affected.
Peri-Implant Mucositis Treatment with a Chlorexidine Gel with A.D.S. 0.5%, PVP-VA and Sodium DNA vs a Placebo Gel: A Randomized Controlled Pilot Clinical Trial
Authors: Lorusso Felice , Tartaglia Gianluca , Inchingolo Francesco , Scarano Antonio
Published: October 2022

Background: Peri-implant mucositis is a bacterial and inflammatory disease of implant surrounding soft tissues. Chlorhexidine (CHX) associated with PVP-VA (Polyvinylpyrrolidone/vinyl acetate) has an adjuvant function in the antibacterial activity: it protects the film-forming layer, due to polymer, from microbial contamination or over-infection, and prolongs its permanence, without a direct action on the tissues and wounds. Sodium DNA is able to improve gingival trophism. The aim of the study was to compare a gel with CHX and antidiscoloration system (A.D.S.) 0.5% with the addition of PVP-VA and sodium DNA with a placebo gel without chlorexidine in peri-implant mucositis treatment. Methods: Trial design: A single center randomized controlled pilot clinical trial was conducted on a total of 24 patients with mucositis, randomly allocated into two groups. In the group (A) (n = 12) patients were treated with a gel with CHX + A.D.S. 0.5% while a placebo gel was used in the group (B) (n = 12). Outcome: Plaque Index (PI) (primary outcome), Bleeding on probing (BOP) and Gingival Index (GI) (secondary outcomes) were assessed at baseline and at 2 weeks after treatment period. Results: Mean PI score recorded at baseline was 2.4 ± 0.4 [95% CI: –2.682/7.482] in the group (A) and 2.2 ± 0.5 [95% CI: –4.153/8.553] in the group (B) (p > 0.05) while mean PI score at 2 weeks was 0.5 ± 0.4 [95% CI: –4.582/5.582] and 1.7 ± 1.9 [95% CI: –9.736/13.14] in the group and in the group respectively (p < 0.05). Mean BOP value at baseline was 57.1 ± 15.2% [95% CI: –136.0/250.2] in the group (A) and 55.3% ± 11.7% [95% CI: –93.36/204.0] (p > 0.05) while mean BOP value at 2 weeks follow-up was 14.3% ± 6.6% [95% CI: –69.56/98.16] (A) and 45.4% ± 9.8% [95% CI: –79.12/169.9] (B) respectively (p < 0.05). Conclusions: A significant reduction in gingival inflammation indexes was found at 2 weeks in patients with peri-implant mucositis treated with a gel with CHX + A.D.S. 0.5% with the addition of PVP-VA and sodium DNA compared to those treated with a placebo gel. Clinical Trial Registration: 2019-004976-20.
Exosomes as Anticancer Drug Delivery Vehicles: Prospects and Challenges
Authors: Zhang Yubo , Li Jian , Gao Wei , Xie Na
Published: October 2022

Exosomes, a subset of extracellular vesicles, are widely present in various body fluids and are involved in mediating intercellular communication. They have received extensive attention as diagnostic markers. The excellent physicochemical and biological properties of exosomes make them great potential drug delivery vehicles for the treatment of cancer and other diseases. However, various challenges need to be addressed for the clinical application of exosomes. This review introduces the biogenesis and uptake of exosomes and compares different approaches for isolation and drug loading, focusing on the application and current challenges of exosomes as drug delivery vehicles in cancer therapy.
Pathogenesis Markers of Hashimoto's Disease—A Mini Review
Authors: Jin Binghui , Wang Shuang , Fan Zhe
Published: October 2022

Hashimoto’s thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors, hereditary inclination, trace elements immune factors, cytokines, and DNA and miRNA all play an important role. Herein, we summarize the precision factors involved in the pathogenesis of HT and offer an update over the past 5 years to provide a theoretical basis for further investigation of the relevant targets for HT treatment.
Human Urinary Kallidinogenase Pretreatment Inhibits Myocardial Inflammation and Apoptosis after Coronary Microembolization by Activating PI3K/Akt/FoxO1 Axis
Authors: Xie Jian , Mo Binhai , Lin Yunhua , Liu Guoqing , Nong Qingqing , Wu Bingling , Xie Yuqian , Li Tao , Li Lang
Published: October 2022

Background: As a fatal cardiovascular complication, coronary microembolization (CME) results in severe cardiac dysfunction and arrhythmia associated with myocardial inflammation and apoptosis. Human urinary kallidinogenase (HUK) can provide a protective function for cardiomyocytes by improving microcirculation. However, the therapeutic effects and underlying mechanisms of HUK in CME-induced myocardial injury remain unclear. Aims: We evaluated the effect of HUK on cardiac protection in a rat model of CME and whether it could restrain myocardial inflammation and apoptosis, and alleviate CME-induced myocardial injury. Methods: We established the CME model by injecting 42 μm inert plastic microspheres into the left ventricle of rats in advance, then the rats were randomly and equally divided into CME, CME + HUK (the dose of HUK at 0.016 PNA/kg/day), CME + HUK + LY (the dose of LY294002 at 10 mg/kg, 30 minutes before modeling), and Sham operation groups. Cardiac function, the serum levels of myocardial injury biomarkers, myocardial inflammation and apoptosis-related genes were measured; and the myocardial histopathological examination was performed at 12 h after the operation. Results: The results revealed that HUK effectively reducing myocardial inflammation, apoptosis, and myocardial infarction area; and improving CME-induced cardiac injury by activating the PI3K/Akt/FoxO1 axis. In addition, these cardioprotective effects can be reduced by the PI3K specific inhibitor LY294002, suggesting that the aforementioned protective effects may be related to activation of the PI3K/Akt/FoxO1 axis. Conclusions: HUK seems to control inflammatory infiltration and cardiomyocyte apoptosis significantly to improve CME-induced cardiac injury via regulating the PI3K/Akt/FoxO1 axis.
The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment
Authors: Hu Zhen , Deng Yulei , Li Binyin
Published: October 2022

Background: The relationship between switching rate of multilayer functional network and cognitive ability in mild cognitive impairment (MCI) and Alzheimers’ disease remains unclear. Methods: We followed up MCI patients for one year and analyzed the association of switching rates with cognitive decline. The iterative and ordinal Louvain algorithm tracked the switching of functional networks, while elastic network regression and Bayesian belief networks were used to test the relationship between network switching rate and cognitive performance cross-sectionally and longitudinally. Results: The switching rate of the default mode network positively correlated with better cognitive function, while that of salience and executive control network was negatively associated with memory and executive function. The lower default mode network (DMN) switching rate predicted MCI progression to dementia, while the lower sensorimotor network switching rate heralded in slower cognitive decline. Conclusions: The present study investigated the predictive effect of switching rate on cognitive performance, as well as MCI progression to dementia. The inverse effect from different functional networks may become useful for early diagnosis and revealing the mechanism of neural networks in cognitive decline.
The Interplay between Cardiovascular Disease, Exercise, and the Gut Microbiome
Authors: Longoria Candace R. , Guers John J. , Campbell Sara C.
Published: October 2022

Cardiovascular disease (CVD) is the leading cause of death worldwide, with physical inactivity being a known contributor to the global rates of CVD incidence. The gut microbiota has been associated with many diseases including CVD and other comorbidities such at type 2 diabetes and obesity. Researchers have begun to examine the gut microbiome as a predictor of early disease states by detecting disruptions, or dysbiosis, in the microbiota. Evidence is lacking to investigate the potential link between the gut microbiota, exercise, and CVD risk and development. Research supports that diets with whole food have reduced instances of CVD and associated diseases, increased abundances of beneficial gut bacteria, and altered gut-derived metabolite production. Further, exercise and lifestyle changes to increase physical activity demonstrate improved health outcomes related to CVD risk and comorbidities and gut microbial diversity. It is difficult to study an outcome such as CVD when including multiple factors; however, it is evident that exercise, lifestyle, and the gut microbiota contribute to improved health in their own ways. This review will highlight current research findings and what potential treatments of CVD may be generated by manipulation of the gut microbiota and/or exercise.
Recurrent Spontaneous Coronary Artery Dissection: Association with Takotsubo Syndrome and Fibromuscular Dysplasia; Comprehensive Review
Authors: Y-Hassan Shams , Abdula Goran , Böhm Felix
Published: October 2022

Spontaneous coronary artery dissection (SCAD) is a non-traumatic, non-iatrogenic, and non-atherosclerotic separation or dissection of the coronary arterial wall by the formation of an intramural hematoma causing a false lumen leading to compression of the true lumen with a varying degree of coronary blood flow obstruction. One of the important and frequent complications of the disease is the in-hospital and long-term SCAD recurrence. SCAD associated with takotsubo syndrome (TS) has been described in case reports, series of cases and in some studies. Some investigators believe that the association of SCAD and TS is a misdiagnosis. The association of SCAD and fibromuscular dysplasia (FMD) has received major attention during the last 10 years. In this report, the short and long-term SCAD recurrence, SCAD association with TS and FMD are reviewed and demonstrated with illustrative images.
Specific Graft Treatment Solution Enhances Vascular Endothelial Function
Authors: Kiss Attila , Szabo Petra Lujza , Dostal Christopher , Arnold Zsuzsanna , Geisler Daniela , Crailsheim Ingo , Folkmann Sandra , Grabenwöger Martin , Podesser Bruno Karl , Winkler Bernhard
Published: October 2022

Background: Saline is still the most widely used storage and rinsing solution for vessel grafts during cardiac surgery despite knowing evidence of its negative influence on the human endothelial cell function. Aim of this study was to assess the effect of DuraGraft©, an intraoperative graft treatment solution, on human saphenous vein segments and further elaborate the vasoprotective effect on rat aortic segments in comparison to saline. Methods: Human Saphenous vein (HSV) graft segments from patients undergoing aortocoronary bypass surgery (n = 15), were randomized to DuraGraft© (n = 15) or saline (n = 15) solution before intraoperative storage. Each segment was divided into two subsegmental parts for evaluation. These segments as well as rat aortic segments stored in DuraGraft© underwent assessment of vascular function in a multichamber isometric myograph system in comparison to Krebs-Henseleit solution (KHS), a physiologic organ buffer solution. Results: Potassium-Chloride (KCL)-induced contraction depicted a tendency towards increase when treated with DuraGraft© compared to saline preservation of HSV segments (23.02 ± 14.77 vs 14.44 ± 9.13 mN, p = 0.0571). Vein segments preserved with DuraGraft© showed a significant improvement of endothelium-dependent vasorelaxation in response to cumulative concentrations of bradykinin compared to saline treated segments (p < 0.05). Rat aortic segments stored in saline showed significantly impaired vasoconstriction (3.59 ± 4.20, p < 0.0001) and vasorelaxation when compared to KHS and DuraGraft© (p < 0.0001). Conclusions: DuraGraft© demonstrated a favorable effect on graft relaxation and contraction indicating preservation of vascular endothelial function. Clinical Trial Registration Number: NCT04614077.
A Correlational Study on Teachers' Occupational Stress, Job Anxiety, Personality Dimensions and Performance
Authors: Borja Arnel D. , Manaig Karen Ang , Buama Chester Alexis C.
Published: October 2022

This study determined the correlations between occupational stress, job anxiety, personality dimensions and instructional competence of elementary teachers. The study employed the descriptive-correlational research design. There were 161 respondents composed of different teachers from small and big schools in the District of Los Banos, Laguna. The study utilized standardized questionnaires to assess the Occupational Stress, Job Anxiety, Personality Dimensions, and Instructional Competence of Elementary Teachers. The data gathered were treated using Mean, Standard Deviation, and ANOVA. The findings revealed that occupational stress has a significant relationship with the teacher's competence in terms of communicative competence. However, occupational stress has no significant relationship between the teacher's competence in terms of instructional competence and social skills. The result also shows that there is a significant relationship between job anxiety in terms of recognition and teacher's competence in terms of instructional competence. However, there is no significant relationship between job anxiety in terms of recognition and teacher's performance in terms of communicative competence and social skills. Similarly, there is a significant relationship between job anxiety in terms of self-esteem and teacher's competence in terms of instructional and communicative competence. However, there is no significant relationship between job anxiety in terms of self-esteem and teacher's competence in terms of social skills. Lastly, the result shows that there is no significant relationship between job anxiety in terms of security, human relations at work, rewards and punishment, future prospects and capacity for work, and teacher's performance in terms of instructional competence, communicative competence, and social skills.
Status of Peace Club Activities in Public Secondary Schools within Kisumu County, Kenya
Authors: Owande Joshua
Published: October 2022

The occurrence of student unrest has been on the rise in Kenya and beyond. This has prompted the introduction of Peace Clubs in Kenyan schools. However, despite these efforts, many schools still experience student unrest. This study, therefore, sought to examine the status of Peace Club activities in schools. The study used a theoretical framework informed by contingency theory and integrative negotiations, and peer mediation theory. The study applied a descriptive survey research design with a sample size of 584 respondents. The researcher used focus group discussions, interviews, and questionnaires to collect primary data, while reviewed publications and reports from the County Director of Education office were used to obtain secondary data. The study applied to content and face validity checks to ascertain the relevance of the research data collection instruments, while reliability was ascertained using the split-half method. The data were then cleaned and coded using descriptive statistics, and the results were presented using frequency distribution tables, percentages, pie charts, and bar graphs. The study found that Peace Club activities didn't exist in most of the schools; most students didn't know about Peace Club activities. In schools where they existed, most of them were not active. It was concluded that the nonexistence and/or inactivity of Peace Clubs activities contributed to the student unrest experienced in schools. The study recommended a modification of the existing policy on the creation of Peace Clubs in schools and the conduction of regular supervision to ensure full implementation of Peace Clubs in schools.
Optimizing the Development of Prototype Learning Mode of Professional Ability Consolidation (PKP) Courses of the PGSD-UT Study Program in the Archipelago Region
Authors: Suhandoko Astri Dwi Jayanti
Published: October 2022

Every semester, Professional Capability Consolidation (PKP) courses are always a scourge for Elementary School Teacher Education (PGSD) students of the Universitas Terbuka (UT). It is due to the lack of student knowledge of the procedures for implementing PKP courses and the limited skills of students in making practical reports. It affects their scores because they do not meet the minimum criteria, and students fail to pass the course. Especially during the pandemic, the implementation of practical courses that are usually held face-to-face is now all based on webinar tutorials. The learning process becomes more difficult for students living on islands with various limitations. This study aims to develop a prototype learning mode to overcome these problems with three main activities, including (1) making procedural video for implementing PKP courses of S1-PGSD, (2) training in writing PKP S1-PGSD UT reports, (3) assisting the undergraduate-PGSD students in the islands face-to-face. The study results show that it was necessary to develop advanced videos as a complement and elaborately detailed procedures for implementing the PKP courses for the students of S1-PGSD UT, the need for writing training with a greater number of meetings and writing practices, and the suitability of holding face-to-face mentoring of PKP courses for the students of S1-PGSD.
Factors Affecting Teacher Performance At SDN Pondok Pucung 05 Bintaro
Authors: Kali Palindangan Linus , Hatiningsih Nawan Katarina , Tjitrosumarto Sumaryati
Published: October 2022

In recent years, SDN Pondok Pucung 05 Bintaro has experienced an alarming decline in the number of students. In fact, students who attend SDN are free of charge because the costs are paid by the government. This phenomenon reflects the problems that are happening at SDN Pondok Pucung 05 Bintaro. One of the problems that urgently and urgently needs to be addressed is the teacher's performance. Based on some literature, it is known that to improve organizational performance; a conducive organizational climate is needed–where there is full employee engagement and employee satisfaction. Therefore, the performance of teachers at SDN Pondok Pucung 05 Bintaro is thought to be influenced by several factors, such as organizational climate, job satisfaction, and teacher engagement. The purpose of this study was to determine the effect of organizational climate and job satisfaction on teacher performance mediated by teacher engagement at SDN Pondok Pucung 05 Bintaro, Indonesia. The research model used in this study is a structural model to test the proposed hypothesis using path analysis. There were 30 teachers who participated in this survey using a saturated sample. The data collection instrument used was a questionnaire distributed to 30 teachers at SDN Pondok Pucung 05 Bintaro. This study indicates that teacher performance in SDN Pondok Pucung 05 Bintaro is influenced by many factors, which organizational climate, job satisfaction, and employee engagement are important parts of the factors supporting the teacher's performance. The limitation of this study is that there are many other variables that can affect teacher performance in SDN Pondok Pucung 05 Bintaro but were not examined in this study, such as work motivation, organizational commitment, school facilities, and perceptions of public and private schools. These variables are suggested to be investigated in further research. The originality of this study shows that these results emphasize the importance of creating and managing organizational climate, job satisfaction, and employee engagement to improve teacher performance at SDN Pondok Pucung 05 Bintaro in carrying out their duties and obligations at school.