bluuebunny/crossref_metadata_2025 huggingface dataset:
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression
Authors: Nasehi Leila , Morassaei Bahareh , Ghaffari Maryam , Sharafi Ali , Dehpour Ahmad Reza , Hosseini Mir-Jamal
Published: September 2022

The comorbidity of depression and high risk of cardiovascular diseases (CVD) have been reported as major health problems. Our previous study confirmed that fluoxetine (FLX) therapy had a significant influence on brain function but not on the heart in depression. In the present study, suberoyanilide hydroxamic acid (SAHA) was proposed as another therapeutic candidate for treatment of depression comorbid CVD in maternal separation model, following behavioral analyses and gene expression level in the heart. Our data demonstrated that SAHA significantly attenuates the NOX-4 gene expression level in treated mice with SAHA and FLX without significant change in NOX-2 expression level. SAHA decreased the gene expression level of peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α) and nuclear respiratory factors (Nrf2) in heart tissues of maternally separated mice. It supposed that non-effectiveness of FLX on mitochondrial biogenesis and NOX gene expression level in the heart of depressed patient can be related to recurrence of depression. It revealed that SAHA not only reversed the depressive-like behavior similar to our previous data but also recovered the heart mitochondrial function via effect on NOX-2, NOX-4, and mitochondrial biogenesis genes' (PGC-1 α, Nrf-2, and peroxisome proliferator-activated receptor- α (PPAR- α)) expression levels. We suggest performing more studies to confirm SAHA as a therapeutic candidate in depression comorbid CVD.
Seasonal Prevalence and Molecular Identification of Thermophilic Campylobacter from Chicken, Cattle, and Respective Drinking Water in Kajiado County, Kenya
Authors: Wanja Daniel W. , Mbuthia Paul G. , Aboge Gabriel O. , Bebora Lilly C.
Published: September 2022

Thermophilic Campylobacter species are a leading cause of human gastroenteritis throughout the world and have been implicated in reproductive disorders (abortion), mastitis, enteritis, and/or diarrhoea in livestock. A cross-sectional survey was conducted in Kajiado County to determine prevalence, seasonality, and molecular detection of thermophilic Campylobacter species (with emphasis on C. jejuni, C. coli, and other thermophilic Campylobacter species) in chicken, cattle, and respective pooled drinking water. A total of 457 samples comprising 265 cattle rectal swabs, 142 chicken cloacal swabs, and 50 trough water samples were collected from 55 randomly selected smallholder farms. Individual samples were subjected to standard techniques for isolation and biochemical tests, followed by singleplex polymerase chain reaction (sPCR) assays for identification and confirmation of genus and species. Overall, thermophilic Campylobacter prevalence was 35.4% (95% confidence interval (95% CI) = 31.0–39.8), with C. jejuni dominating at 55.6% (95% CI = 47.9–63.3%) over C. coli in all sample types. The highest thermophilic Campylobacter prevalence was observed in cloacal swabs of live chicken at 44.4% (95% CI = 36.2–52.6%), followed by rectal swabs from live cattle at 30.9% (95% CI = 25.3–36.5%). Water samples from cattle drinkers/trough were found to be contaminated at 34% (95% CI = 20.9–47.1%). The isolation rate was higher in cattle under the confinement system (44.3%) (95% CI = 36.1–52.5%) than in those under the free-roaming grazing system. Thermophilic Campylobacter species were isolated in both seasons, with higher prevalence (39.8% (95% CI = 33.6–45.9)) recorded during rainy and cold season in all sample types except for water. There was significant (

P
<
0.05

) association between season and thermophilic Campylobacter occurrence, even though there were no statistical differences in the prevalence values across the two seasons. Results of this study demonstrate that cattle, chicken, and respective drinking water harbour potentially pathogenic thermophilic campylobacters, with C. jejuni being widely distributed among farms. It is possible that seasonal variations and cattle confinement result in differences in thermophilic Campylobacter carriage. Further epidemiological and phylogenetic studies comparing distribution of thermophilic Campylobacter spp. isolates in livestock, environmental, and human samples are recommended to establish source attribution to reduce the impact of resultant diseases for the wellbeing of public and livestock.
A Control Strategy for Ground Fault on the AC Side of MMC-HVDC System
Authors: Li Hua , Guo Liwei
Published: September 2022

This study explores a control strategy for a flexible Modular Multilevel Converter-High Voltage Direct Current (MMC-HVDC) system when there is an asymmetrical fault with the AC side system voltage. Aiming at the characteristic that the fault system has a negative sequence current path, this paper proposes a positive/negative sequence controller to ensure the output of original active power, and the validity of the proposed control strategy is verified by using simulation software PSCAD/EMTDC.
Status of Agricultural Mechanization in Ghana: Insight from Farmers’ Perception, Population, and Nonagricultural Sector Growth
Authors: Akolgo Gilbert Ayine , Quaye Duke Nii Darko , Alhassan Abdul-Rauf Malimanga , Asosega Killian Asampana , Nunoo Ebenezer , Akimsah Jedaiah Osman A. , Deho Michael Elorm , Atta-Darkwa Thomas
Published: September 2022

The growing human population is a driver for higher food demands with a need to scale agricultural production and maintain security of the food supply chain. Thus, there is a need to increase the adoption and improvement of mechanized systems in agriculture, especially where needed labor is also drifting into nonagricultural production sectors. With this view, the relationship or link between population and employment in nonagricultural sector in Ghana (West Africa) to agricultural mechanization was tested to ascertain any such validity. This formed the primary basis for this study and furthered on to establish the current level of agricultural mechanization within the country through measuring effect of available farm energy sources on farm sizes under cultivation. The methods employed included a structured questionnaire administered to farmers and other agricultural stakeholders to determine the level of mechanization, readiness to adopt/accept mechanization technology, level of usage of mechanization technologies, and ownership of machinery. The Statistical Package for the Social Sciences (SPSS version 20) software was used to model and analyze data obtained including a multiple regression method for the relationship between parameters. The overall level of agricultural mechanization in Ghana was found to be very low with 77.6% of the farm operations being performed manually. The level of the tractor power availability in Ghana was found to have increased from 0.0207 kW/ha in the year 2004 to 0.0588 kW/ha in the year 2020 and is expected to increase to 0.0752 kW/ha in the year 2025. The power availability valued in this study was also found to be low compared with that in other developing countries. Statistically, both employment in the service sector and population growth were significant determinants (

Adjusted
−

R

2

=
0.9172

) in the variations in the level of mechanization of agriculture in Ghana and policymakers will have to make adjustments in policies to take note of these indicators most often underplayed. Advocacy for higher levels of mechanization of agricultural operations must increase as it is critical to the overall cost of production in agriculture as this study also found out that mechanized operations were between 21.3% and 53.8% cheaper than manual operations.
On the Nonlinear Mathematical Model Representing the Coriolis Effect
Authors: Gurefe Yusuf , Pandir Yusuf , Akturk Tolga
Published: September 2022

In this study, the traveling wave solutions of a nonlinear partial differential equation (NPDE) called as Geophysics Korteweg-de Vries (GpKdV) equation are obtained using the modified exponential function method (MEFM). Coriolis effect is stated with the help of this model used in geophysics. The nonlinear model has a Coriolis coefficient representing this effect.
Analysis of T-Spherical Fuzzy Matrix and Their Application in Multiattribute Decision-Making Problems
Authors: Garg Harish , Saad Muhammad , Rafiq Ayesha
Published: September 2022

The aim of this study is to introduce an innovative concept of T-spherical fuzzy matrix, which is a hybrid structure of fuzzy matrix and T-spherical fuzzy set. This article introduces the square T-spherical fuzzy matrix and constant T-spherical fuzzy matrix and discusses related properties. Determinant and the adjoint of a square T-spherical fuzzy matrix are also established, and some related properties are investigated. An application of the T-spherical fuzzy matrix in decision-making problem with an illustrative example is discussed here. Then, in the end, to check capability and viability, a practical demonstration of the planned approach has also been explained.
Diversity of Ethiopian Durum Wheat Landraces for Resistance to Stem Rust Seedling Resistance Genes
Authors: Chiko Silas , Kebede Gessese Mesfin , Shimelash Daniel , Haile Wondimeneh Taye , Melo Belay Yebo , Wassie Adera Sisay , Lakore Zemach Sorsa , Kassie Fentanesh Chekole
Published: September 2022

Stem rust caused by Puccinia graminis f. sp. tritici (Pgt) is one of the most important diseases of wheat worldwide. Breeding for resistance to diseases is the most important approach for mitigation of yield losses. This study was conducted to estimate the diversity of all stage stem rust resistance (ASR) genes on the 142 durum wheat landrace accessions at seedling stage. The study was conducted in greenhouse at Ambo Plant Protection Research Center on the 142 durum wheat landrace accessions using 20 differential lines, one susceptible line (McNair), and eight Pgt races. The result depicted the presence of Sr7b, Sr8a, Sr9b, Sr10, Sr11, Sr13, Sr17, Sr30, Sr31, Sr36, and SrTmp in the Ethiopian durum wheat accessions. Among the 142 durum wheat accessions, 83 accessions were identified for possessing single ASR genes, and four accessions including the universal susceptible line (McNair) did not have effective resistance genes to the pathogen races tested in this study. The remaining 55 accessions had either a combination of two resistance genes, unknown number and kind of genes, or unidentified genes displaying resistance across all the pathogen races. This study demonstrated the prevalence of significant genetic diversity for stem rust ASR genes in the Ethiopian durum wheat landraces.
Inertial Forces and Torques Acting on a Spinning Annulus
Authors: Usubamatov Ryspek , Kapayeva Sarken
Published: September 2022

The many publications related to the gyroscope theory consider the action of the inertial torques on the spinning disc. All of them have simplified expressions for the inertial torques and mathematical models of the gyroscope motions do not validate by practice. Recent research in the theory of the gyroscopic effects for rotating objects solved problems with mathematical models for interrelated inertial torques generated by the spinning disc, bar, and ring and their motions. Practitioners of engineering designed gyroscopic devices with spinning rotors whose geometry can be an annulus or similar designs. Such spinning annulus generates inertial torques whose expressions differ from the disc bar and ring and hence another mathematical model describes the motions of the gyroscopic devices. The value of gyroscopic effects of the devices with spinning annulus is bigger than for the disc-type rotor. This manuscript presents mathematical models for the inertial torques generated by the spinning annulus and the interrelated angular velocities of the gyroscopic devices about axes of rotation.
Shield Cutting Pile‐Group Implementation Effects on the Superstructure
Authors: Zhang Chi , Ma Shiju , Guo Yuancheng , Li Mingyu , Fu Kui
Published: September 2022

The shield tunneling method is widely used in urban subway construction. However, as the layer stress state changes during shield tunnel construction, layer displacement and surface deformation occur accordingly. This study tries to investigate the settlement and deformation of the masonry structure in shield cutting the composite foundation of group piles in a shield tunnel project at Zhengzhou Metro Line 5. To understand the distribution characteristics and changing rules of building settlement during the process of shield cutting group piles composite foundation passing through the masonry structure, a thorough analysis of the ground surface settlement and building settlement, including on‐site measured, was conducted. The results show that piles go down through a composite foundation during shield cutting. The cumulative maximum settlement and maximum differential settlement of the masonry structure were concentrated at the intersection of the tunnel axis and the building. The longitudinal distribution of the cumulative settlement of the south and north wall of the masonry structure changes continuously with the change of the position of the shield excavation surface. That behavior may cause the building to be tilted and deformed and cause the structure to undergo rigid rotation and twisting deformation. Based on the composite pile foundation project of the Shield Tunnel Cutting Group in a specific section of Zhengzhou Metro Line 5, this paper analyzes the surface settlement and foundation settlement data of the building caused by the construction of the shield. It obtains the changes of the surface settlement and the settlement of the foundation of the building. No other changes have been made to the existing cracks in the external walls of the building. At the same time, because of the low angle between the longitudinal axis of the masonry structure and the tunnel axis (22°) and the positive effect of the ring beam and column of the structure in the building, it is clear that the construction of this project has little effect on the upper building, thus showing improved control.
Design of the Artificial Intelligence Vocal System for Music Education by Using Speech Recognition Simulation
Authors: Bai Junqing
Published: September 2022

At present, computer technology is not limited to the network but to many aspects of spread out, including artificial intelligence technology, signal processing technology, speech recognition technology, and so on which have been better developed, and music teaching has also obtained certain achievements. If the detected speech data have no other clutter in the speech, then the endpoint detection can achieve ideal results. The music education system includes the development of four dimensions: WEB terminal, mobile terminal, web interface, and database. Using the powerful functions of computers, such as computing functions and processing functions, combined with advanced intelligent technology and related equipment, the intelligent learning model based on computer technology is established. It can be applied in college teaching, combined with the actual needs of current college music teaching, corresponding to the curriculum and teaching plan issued by the school, combined with the design of online learning system and reasonable use of computer technology to build a vocal music education system. The intelligent system can improve the requirements of vocal music education management level, teaching organization ability, and teaching platform operation ability.
Regularized Least Squares Recursive Algorithm with Forgetting Factor for Identifying Parameters in the Grinding Process
Authors: Yu Yang , Deng Rui , Yu Gang , Wang Yu , Yang Guodong , Zhao DaYong
Published: September 2022

This paper investigates a parameter identification problem in the grinding process. Due to the data saturated phenomenon and the ill‐posed of parameter identification inverse problem, this paper presents a regularized least squares recursive algorithm with a forgetting factor (RLSRAFF), the basic idea of which is to combine the forgetting factor with regularization parameters. Moreover, based on RLSRAFF, this paper verifies the recursive calculation of criterion function, analyzes the effect of calculation error from the gain matrix and proves the convergence of the proposed algorithm. Finally, effectiveness of RLSRAFF is verified by simulation experiments and grinding data. Compared with other algorithms, RLSRAFF can give a more convergence rate to the real data and reduce the error from the true value.
Experimental Study on Heat Transfer Process Optimization of Heat Storage Wall of the Heat Pump in Tunnel Surrounding Rock in the Cold Region
Authors: Li Yafei , Qi Dianwei , Yan Hongchao , Zhang Jiaqi
Published: September 2022

For tunnels in cold or serious cold areas, the problem of leaking in the spring thawing period is very frequent, which will cause various tunnel diseases due to freezing. By using the surrounding rock geothermal energy in the tunnel project, especially the tunnel project below the permafrost layer, the cold area tunnel heat pump system is able to improve the overall heating energy efficiency as the side temperature regarding the heat pump evaporation increases, that furtherly serves the surrounding supporting building facilities. Inspired by this system and the active and passive coupling building technology, a heat recovery type of heat storage wall model is proposed in this research. By describing the heat transfer process regarding the heat recovery type of heat storage wall and carrying out the experimental research, its feasibility and effectiveness are verified. The results show that when the outdoor ambient temperature in Urumqi is −7~−15°C and the instantaneous total solar radiation reaches the range of 0~1108 W/m2, this kind of wall can create hot wall-near air whose temperature is 11.89°C higher than the ambient temperature for providing a high-quality air heat source for the air source heat pump when the temperature is low, thereby significantly improving the air source heat pump heating system efficiency. Without the photovoltaic and photothermal equipment, the heat recovery type of heat storage wall can make the utilization rate of solar energy reach 13% to 20%, even up to 36%.
The Prognostic Value of Preoperative Fibrinogen in Patients with Radical Cholecystectomy
Authors: Wu Yuchen , Zhang Shengjie , Qian Xu , Zhu Jing , Zheng Shuang , Wu Jian , Huang Xiaodan
Published: September 2022

Background and Aims. There is currently a lack of suitable hematological markers as a complement to pathological factors in predicting the prognosis of patients with gallbladder cancer. The study aimed to investigate the clinical value of preoperative fibrinogen levels in assessing the prognosis of patients with gallbladder cancer after radical surgery. Methods. The study retrospectively analyzed 260 gallbladder cancer patients who underwent radical resection. Time-dependent receiver operating characteristic (ROC) curves were used to calculate the optimal cut-off values of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and fibrinogen. Besides, univariate and multivariate analyses of disease-free survival (DFS) and overall survival (OS) were performed to determine independent markers in peripheral blood. Then, subgroup analyses of fibrinogen in different degrees of differentiation, age, gender, and BMI were performed by log-rank test. Result. The cut-off values of fibrinogen, CEA, and CA19-9 were set at 2.97 g/L, 2.17 ng/mL, and 41.1 U/mL, respectively. The results showed that the preoperative fibrinogen level was associated with tumor size, degree of differentiation, TNM stage, and CA19-9 levels. Multivariate analyses indicated that advanced TNM stage, excessive fibrinogen, CEA, and CA19-9 levels were independent risk factors for postoperative DFS. And gallbladder neck tumors, poor differentiation, cancer nodules, advanced TNM stage, excessive fibrinogen, and CEA levels were independent adverse factors for postoperative OS. Notably, the preoperative excessive fibrinogen was an independent adverse factor for both DFS (

p
=
0.044

,

HR
=
1.629

, 95%

CI
=
1.014
−
2.618

) and OS (

p
=
0.006

,

HR
=
2.328

, 95%

CI
=
1.272
−
4.261

) in patients with gallbladder cancer. The subgroup analyses further indicated that patients with high-level of fibrinogen had both poorer DFS (

p
=
0.002

) and OS (

p
=
0.005

) than patients with poorly-differentiated gallbladder cancer. And for well-differentiated gallbladder cancer, patients with high fibrinogen levels had poorer OS (

p
=
0.004

), but no significant difference in DFS (

p
=
0.062

). Besides, fibrinogen was more significant in GBC patients with higher BMI (>22.62) or older age (>60 yrs) and was not affected by gender. Conclusion. Elevated preoperative fibrinogen level was independently associated with poor postoperative DFS and OS in patients with gallbladder cancer, especially for poor differentiation.
Spotted Temporal Lobe Necrosis following Concurrent Chemoradiation Therapy Using Image-Guided Radiotherapy for Nasopharyngeal Carcinoma
Authors: Chiang Yu-Wei , Liao Li-Jen , Wu Chia-Yun , Lo Wu-Chia , Shueng Pei-Wei , Hsu Chen-Xiong , Guo Deng-Yu , Hou Pei-Yu , Hsieh Pei-Ying , Hsieh Chen-Hsi
Published: September 2022

Background. To explore spotted temporal lobe necrosis (TLN) and changes in brain magnetic resonance imaging (MRI) after image-guided radiotherapy (IGRT) in a patient with nasopharyngeal carcinoma (NPC). Case presentation: a 57-year-old male was diagnosed with stage III NPC, cT1N2M0, in 2017. He underwent concurrent chemoradiation therapy (CCRT) with cisplatin (30 mg/m2) and 5- fluorouracil (5-FU, 500 mg/m2) plus IGRT with 70 Gy in 35 fractions for 7 weeks. The following MRI showed a complete response in the NPC. However, the patient suffered from fainting periodically when standing up approximately 3 years after CCRT. Neck sonography showed mild atherosclerosis (< 15%) of bilateral carotid bifurcations and bilateral small-diameter vertebral arteries, with reduced flow volume. The following MRI showed a 9 mm × 7 mm enhancing lesion in the right temporal lobe without locoregional recurrence, and TLN was diagnosed. The lesion was near the watershed area between the anterior temporal and temporo-occipital arteries. The volume of the necrotic lesion was 0.51 c.c., and the mean dose and Dmax of the lesion were 64.4 Gy and 73.7 Gy, respectively. Additionally, the mean dose, V45, D1 c.c. (dose to 1 ml of the temporal lobe volume), D0.5 c.c. and Dmax of the right and left temporal lobes were 11.1 Gy and 11.4 Gy, 8.5 c.c. and 6.7 c.c., 70.1 Gy and 67.1 Gy, 72.0 Gy and 68.8 Gy, and 74.2 Gy and 72.1 Gy, respectively. Conclusion. Spotted TLN in patients with NPC treated by IGRT may be difficult to diagnose due to a lack of clinical symptoms and radiological signs. Endothelial damage may occur in carotid and vertebral arteries within the irradiated area, affecting the small branches supplying the temporal lobe and inducing spotted TLN. Future research on the relationship between vessels and RT or CCRT and the development of TLN is warranted.
Multivariate Statistical Analysis Based on Random Matrix to Explore the Promotion Effect of Network Resource Sharing Mode on Physical Education
Authors: Ding Bin , Jian Yanchun , Yuan Xingliang
Published: September 2022

Multivariate statistical analysis is a new statistical method emerging in recent years. Due to the continuous update and continuous development of Internet technology, statistical analysis of data from all walks of life is required. The method of multivariate statistics was soon applied to all walks of life, bringing great convenience to people’s work and industry. The method of multivariate statistics is used to process and evaluate the data, guide the school’s physical education work, and make suggestions for various functional units. This paper focuses on the multivariate statistical analysis of principal components and factors, uses factor analysis to comprehensively evaluate college students, and uses the variance method to make statistics on the four-year physical education performance of 141 undergraduates in grades 13 and four subjects. And based on this, the effect of different majors on their academic achievement is discussed. This paper believes that in college physical education, this method should be applied to daily physical education, and students should be rationally analyzed and scientifically evaluated. This model can make a comprehensive investigation of the education work so that their education work can be improved more effectively, and sports talents in colleges and universities can get better development.
The Design of Incentive Mechanism for Policy‐Oriented Guarantee Institutions’ Digital Transformation in China
Authors: Lv Youqing , Ma Guojian , Lv Linlin , Ding Juan
Published: September 2022

Currently, China is actively promoting the reform process of the digital economy, and the digital transformation of the credit financing guarantee sector is gradually emerging. As the core driving force for the progress of digital transformation, the optimal design of the incentive mechanism is undoubtedly essential. Based on the principal‐agent relationship between local governments and policy‐oriented guarantee institutions, this study constructs a basic incentive model (model I) and an incentive model introducing a regulatory signal (model II), empirically analyzes the digital transformation effort of guarantee institutions under the influence of different factors and discusses how local governments should design the optimal incentive mechanism. The results show that the digital transformation effort level of guarantee institutions in model II is higher than that in model I, while the incentive intensity of local governments in model II is lower than that in model I. Within the range of guarantee compensation rate less than a specific threshold, the risk perception degree has negative effects on the effort level and incentive intensity of DT. In addition, the regulatory intensity has a constant negative effect on the incentive intensity of the DT, while it has a negative effect on the effort level of the DT only if the guarantee capacity is below a specific threshold. The research results can provide practical guidance for local governments to effectively promote digital transformation activities and improve the competitiveness of credit financing guarantee.
Application of Artificial Intelligence Technology in Cross-Cultural Communication of Intangible Cultural Heritage
Authors: Zhang Jiankun , Jing Yanhui
Published: September 2022

Intercultural communication not only promotes the emergence and development of multiculturalism but also promotes cultural exchanges on a global scale. China has rich resources and a long history. Because of its unique national characteristics, it is even more famous and unique in the world today. However, with the transformation of society, cross-cultural dissemination and blending are inevitable. Intangible cultural heritage is an important cultural form, and its international dissemination is increasingly attracting people’s attention. The spontaneous inheritance mode of intangible cultural heritage, which is mainly based on oral and heart teaching, has been unable to adapt to the development of society and has gradually moved away from people’s sight. How to better protect and inherit intangible cultural heritage is an important topic in the field of current cultural exchanges. However, due to the particularity of intangible culture, especially its abstract nature, it is difficult to show it to the public, which makes it difficult to protect and promote intangible cultural heritage. The application of the advantages of artificial intelligence technology to the dissemination of intangible cultural heritage is to solve these problems, which can not only make it innovative in protection but also promote its sustainable development to a certain extent. This paper discusses the application of artificial intelligence technology in the protection and dissemination of intangible cultural heritage from multiple perspectives and points out that the advantage of artificial intelligence is that although it cannot be creatively inherited, it can be reproduced in a historical moment, so as to meet people’s needs for intangible cultural heritage. It can also be found in the questionnaire for the visitors that 66% of the visitors prefer to learn about the intangible cultural heritage through experience and feel that the personal experience is more intuitive and interesting. Artificial intelligence technology has great advantages in disseminating intangible cultural heritage.
In Vitro and In Vivo Antiproliferative Actions of Solanum gilo Raddi (Solanaceae) Fruit Extract on Breast Tissues
Authors: Tchoupang Edwige Nana , Yadji Vincent , Wangbara Jean Baptiste , Kemegne Sipping Marius Trésor , Zingue Stéphane , Njamen Dieudonné
Published: September 2022

Background. Menopause is a normal event characterized by a drop in estrogen’s production, leading to numerous symptoms. To face these later, women rely on hormone replacement therapy (HRT), which alleviates numerous menopausal symptoms. Unfortunately, long-term exposure to estrogens is associated with an increase in endometrial and breast cancers. This study dealt with the evaluation of in vitro and in vivo antiproliferative effects of Solanum gilo Raddi, a plant used in folk medicine to treat tumors in Cameroon. Materials and Methods. The in vitro antiproliferative effect of S. gilo fruit extract was investigated through the well-characterized MTT assay in one normal and three cancerous breast cells. For the in vivo study, one normal group (NOR) of rats received distilled water (vehicle), and five other groups (n = 6) were treated either with tamoxifen (3.3 mg/kg BW) as standard or with the vehicle (negative control) or S. gilo fruit hydroethanolic extract (125, 250, and 500 mg/kg BW). The treatments were administered concomitantly with the E2V to induce breast hyperplasia for 16 weeks, and the endpoints were the histopathology of the mammary glands and some biochemical parameters. Results. The S. gilo extract significantly inhibited human (MCF-7 and MDA-MB-231) and rodent (4T1) breast carcinoma cell growth. Rats exposed only to E2V presented atypical mammary hyperplasia compared to the normal parenchyma observed in normal rats. While rats treated with S. gilo extract at the dose of 125 mg/kg BW showed a microarchitecture of mammary glands with moderate hyperplasia, the higher doses (250 and 500 mg/kg) inhibited mammary gland hyperplasia compared to the E2V group. Conclusion. S. gilo fruit extract has antiproliferative constituents that could help to fight against estrogen-dependent breast cancer, thanks to their ability to scavenge free radicals, as exhibited in this study.
Design of the Physical Education Teaching System by Using Edge Calculation and the Fuzzy Clustering Algorithm
Authors: Ning Han
Published: September 2022

With the increasing number and types of terminal access, real-time processing of increasingly complex Internet of things applications has become increasingly difficult. On the one hand, cloud computing environment in virtual reality, ultrahigh definition live video, intelligent manufacturing, and other application fields put forward complex, diverse, real-time, and other new business requirements. On the other hand, modern IOT terminals have shortcomings such as insufficient computing power and limited battery capacity, which make it difficult to provide real-time processing for Internet applications. The emergence of edge computing services provides effective solutions for these applications, which can improve the local data processing capacity, shorten the data transmission delay, and reduce the hardware cost to a certain extent. Since computing offload, resource allocation, cache content placement, and edge server deployment are the basis of localized data processing and resource allocation, their performance is closely related to the efficiency and accuracy of data processing in the whole system. In the application of the current system, online learning resources and cutting-edge software and hardware teaching environment continue to emerge, shaping a unique smart classroom. The system proposed in this paper not only has the traditional physical education knowledge but also the advanced visualization principle. The combination of them can promote the practice of the new concept of physical education. Through research on edge computing and resource allocation, this paper applies it to the development of cloud computing environment and sports teaching visualization system so that the cloud computing environment and sports teaching visualization system can flourish.
Structure of k‐Quasi‐(m, n)‐Isosymmetric Operators
Authors: Mahmoud Sid Ahmed Ould Ahmed , Beiba El Moctar Ould , Hamidou Jah Sidi , Sidi Maawiya Ould
Published: September 2022

The investigation of new operators belonging to some specific classes has been quite fashionable since the beginning of the century, and sometimes it is indeed relevant. In this study, we introduce and study a new class of operators called k‐quasi‐(m, n)‐isosymmetric operators on Hilbert spaces. This new class of operators emerges as a generalization of the (m, n)‐isosymmetric operators. We give a characterization for any operator to be k‐quasi‐(m, n)‐isosymmetric operator. Using this characterization, we prove that any power of an k‐quasi‐(m, n)‐isosymmetric operator is also an k‐quasi‐(m, n)‐isosymmetric operator. Furthermore, we study the perturbation of an k‐quasi‐(m, n)‐isosymmetric operator with a nilpotent operator. The product and tensor products of two k‐quasi‐(m, n)‐isosymmetries are investigated.
Subsurface Tectonic Inferences of the Adamawa Region of Cameroon from EMAG2 Magnetic Data
Authors: Njeudjang Kasi , Yandjimain Justine , Bouba Apollinaire , Djousse Kanouo Boris Merlain , Teikeu William Assatse , Djongyang Noël , Ndougsa-Mbarga Théophile
Published: September 2022

The study area includes an area between 6° to 8°N and 11° to 15°E. Geologically, it belongs to Precambrian basement (granites, gneisses), Proterozoic, and Archean (volcanic) series, showing the main heat sources of Cameroon. The purpose of this study deals to analyze and interpret the EMAG2 magnetic data in the Adamawa area using various advanced processing techniques. Thus, the mapping and depth estimation of underground structures are realized. The analysis of aeromagnetic map of the reduction to equator (RTE) in Adamawa area reveals rapidly evolving subsurface geological presented its lithological and structural. In the same, the power spectrum-processing tool clearly emphasizes shallow and deep underground heat sources. Two magnetic source location methods (source parameter imaging and analytical signal) are used to characterize of the source. The estimated magnetic source depths from source parameter imaging (SPI) are between 0.3 km and 22 km. The analytical signal ranges from 0.2 km to 31 km. In addition, the comparative study of 2D magnetic modelling showed that the basement is affected by the faults in the main directions of N-S, NE-SW, NW-SE, and WNW-ESE. The resulting structural map based on the tectonic map of Adamawa magnetic basement is a document that can simplify future hydrological and geothermal exploration.
Research on Influencing Factors of Knowledge Hiding Behavior in Socialized Q&A Communities: Taking Zhihu as an Example
Authors: Li Wen-Zhu , Chen Jiang-Fei , Feng Xin , Yan Qiang
Published: September 2022

With the normalization of epidemic prevention and control, the expression of the public’s demand for health information on online platforms continues to increase, while knowledge hiding behavior has seriously hindered the communication and dissemination of epidemic prevention knowledge and has a negative impact on public communication and access to health information in the socialized Q&A communities. Therefore, further stimulating diving users' activity and reducing their knowledge hiding behavior have become the key to the sustainable development of epidemic prevention and control and communities. Based on the social cognition theory, from the perspective of individual cognition and external environment, this study constructs a theoretical model of the influencing factors of users’ knowledge hiding behavior in the socialized Q&A communities in the post‐epidemic era and puts forward relevant assumptions. 151 effective questionnaires are collected and an empirical analysis is carried out by using the structural equation model. The results show that outcome expectation, community atmosphere, and requesting negatively affect knowledge hiding behavior; self‐efficacy, outcome expectation, and community atmosphere negatively affect the three different types of knowledge hiding behavior, which are evasive hiding, playing dumb, and rationalized hiding; community atmosphere positively affects outcome expectation, which plays a significant intermediary effect between community atmosphere and knowledge hiding behavior. The research content and relevant conclusions of this study deepen and expand the connotation and extension of knowledge hiding behavior in the negative performance of Q&A communities. From the perspective of practical application, it can also effectively reduce knowledge hiding behavior, grasp the development direction of public health needs, and strengthen the dissemination of epidemic prevention and control knowledge.
Therapeutic Approaches in COVID-19 Patients: The Role of the Renin-Angiotensin System
Authors: Ketabchi Farzaneh , Jamzad Sina
Published: September 2022

Two and a half years after COVID-19 was first reported in China, thousands of people are still dying from the disease every day around the world. The condition is forcing physicians to adopt new treatment strategies while emphasizing continuation of vaccination programs. The renin-angiotensin system plays an important role in the development and progression of COVID-19 patients. Nonetheless, administration of recombinant angiotensin-converting enzyme 2 has been proposed for the treatment of the disease. The catalytic activity of cellular ACE2 (cACE2) and soluble ACE2 (sACE2) prevents angiotensin II and Des-Arg-bradykinin from accumulating in the body. On the other hand, SARS-CoV-2 mainly enters cells via cACE2. Thus, inhibition of ACE2 can prevent viral entry and reduce viral replication in host cells. The benefits of bradykinin inhibitors (BKs) have been reported in some COVID-19 clinical trials. Furthermore, the effects of cyclooxygenase (COX) inhibitors on ACE2 cleavage and prevention of viral entry into host cells have been reported in COVID-19 patients. However, the administration of COX inhibitors can reduce innate immune responses and have the opposite effect. A few studies suggest benefits of low-dose radiation therapy (LDR) in treating acute respiratory distress syndrome in COVID-19 patients. Nonetheless, radiation therapy can stimulate inflammatory pathways, resulting in adverse effects on lung injury in these patients. Overall, progress is being made in treating COVID-19 patients, but questions remain about which drugs will work and when. This review summarizes studies on the effects of a recombinant ACE2, BK and COX inhibitor, and LDR in patients with COVID-19.
Rolling Bearing Fault Detection System and Experiment Based on Deep Learning
Authors: Zhang Bo
Published: September 2022

The current situation of frequent small-scale accidents shows that the existing methods have not completely solved the problem of bearing failures, and new research methods need to be used to complete the study of bearing failures. To prevent the failure of rolling bearings and meet the need for timely detection of faults, this research is based on deep learning. Using the combination of deep transfer learning and metric learning methods, the identification and analysis of bearing multi-state vibration signals under different working conditions are carried out. The combination of SSAE-based similarity measurement criteria and deep transfer learning can reduce the differences between different domains. It is difficult to distinguish the data samples at the boundary and diagnose the problems that the physical meaning is difficult to understand. Through the bearing fault diagnosis analysis, the validity of the deep learning diagnosis model proposed in this paper is verified. The results show that the detection accuracy of the rolling bearing fault detection method based on LCM-SSAE is 0.6 percentage points higher than that of the rolling bearing fault detection method based on SSAE, which proves that the method is suitable for the fault detection of rolling bearing, and it also shows the effectiveness and robustness of the fault detection system of rolling bearing.
The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis
Authors: Fang Chongkai , Huang Yue , Chen Chuyao , Nie Duorui , Lin Jietao , Xiao Zhiwei , Li Saimei , Liu Silin , Luo Rui , Lin Hongtong , Zhong Chong , Huang Xuewu , Shao Cui
Published: September 2022

Background. Colorectal cancer liver metastasis (CRLM) is a high degree of malignancy with rapid disease progression and has a poor prognosis. Both serum apolipoprotein A-I (ApoA-I) and neutrophil-to-lymphocyte ratio (NLR) play key roles in anti-inflammation and antitumor. This study is aimed at evaluating the implication of serum ApoA-I level in combination with NLR in the prognosis of CRLM. Methods. We retrospectively analyzed the serum ApoA-I level and NLR in 237 patients with CRLM. Cox regression analyses were used to identify the independent prognostic significance of these indicators. Kaplan-Meier method and Log-rank test were applied to compute overall survival (OS). Both the ApoA-I and NLR were divided into three levels, according to their medians. A risk-stratified prediction model was established to evaluate the prognosis of patients with CRLM. The ROC curve AUC values were applied to evaluate the capability of the model. Results. Higher levels of ApoA-I and lower NLR were strongly associated with prolonged OS (Log-rank test,

P
<
0.05

). The patients were then grouped into three queues according to the ApoA-I level and NLR. There was a crucial diversity in the OS (

P
<
0.001

) between the high-risk (

ApoA
−
I
≤
1.03

 g/L and

NLR
>
3.24

), medium-risk (

ApoA
−
I
>
1.03
 

g/L or

NLR
≤
3.24

) and low-risk groups (

ApoA
−
I
>
1.03
 

g/L and

NLR
≤
3.24

). The AUC value of the prediction model (

AUC
=
0.623

, 95% CI: 0.557-0.639,

P
=
0.001

) was higher than other individual indicators (including ApoA-I, NLR, cT classification, and cN classification). Additionally, the association of the prediction model and cTN classification (

AUC
=
0.715

, 95% CI: 0.606-0.708,

P
<
0.001

) was better than the model and cTN classification alone. Conclusion. The combination of ApoA-I level and NLR could be a prognostic indicator for CRLM.
The Biosorption of Copper(II) Using a Natural Biofilm Formed on the Stones from the Metro River, Malang City, Indonesia
Authors: Kurniawan Andi , Ulfa Siti Mariyah , Chamidah Chamidah
Published: September 2022

Biofilm is the predominant habitat of microbes in aquatic ecosystems. Microhabitat inside the biofilm matrix is a nutrient-rich environment promoted by the adsorption of nutrient ions from the surrounding water. Biofilms can not only adsorb ions that are nutrients but also other ions, such as heavy metals. The ability of biofilm to attract and retain heavy metals, such as copper(II), makes biofilms a promising biosorbent for water pollution treatment. The present study analyzes the characteristics of copper(II) adsorption by biofilms naturally formed in the river. The biofilms used in this study grow naturally on the stones in the Metro River in Malang City, Indonesia. Methods to analyze the adsorption characteristics of copper(II) by biofilms were kinetics of the adsorption and adsorption isotherm. The maximum adsorption amount and the adsorption equilibrium constant were calculated using a variant of the Langmuir isotherm model. In addition, the presence of the functional groups as suggested binding sites in biofilm polymers was investigated using the Fourier transform infrared (FTIR) analysis. The results indicate that copper(II)’s adsorption to the biofilm is a physicochemical process. The adsorption of copper(II) is fitted well with the Langmuir isotherm model, suggesting that the adsorption of copper(II) to a biofilm is due to the interaction between the adsorption sites on the biofilm and the ions. The biofilm’s maximum absorption capacity for copper(II) is calculated to be 2.14 mg/wet-g of biofilm, with the equilibrium rate constant at 0.05 L/mg. Therefore, the biofilms on the stones from river can be a promising biosorbent of copper(II) pollution in aquatic ecosystems.
KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging
Authors: Zhu Mingsheng , Ling Xian , Zhou Shan , Meng Ping , Chen Qiyan , Chen Shuangqin , Shen Kunyu , Xie Chao , Kong Yaozhong , Wang Maosheng , Zhou Lili
Published: September 2022

Introduction: Aged kidney is characterized by mitochondrial dysfunction, cellular senescence, and fibrogenesis. The activation of Wnt/β-catenin signaling plays an important role in the initiation of kidney aging. However, the inhibiting strategies have not been discovered in detail. Here, we compared the therapeutic effects of two β-catenin inhibitors, KYA1797K and ICG-001, to assess their superiority. Methods: Two-month-old male C57BL/6 mice which had undergone unilateral nephrectomy and received D-galactose (D-gal) injection were co-treated with KYA1797K or ICG-001 at 10 mg/kg/day for 4 weeks. Human proximal renal tubular cells were treated with D-gal and KYA1797K/ICG-001 to compare their effects. Results: Compared with ICG-001, which inhibits β-catenin pathway through blocking the binding of β-catenin and cAMP response element-binding protein (CREB)-binding protein (CBP), KYA1797K, a novel small molecule destabilizing β-catenin through activating Axin-GSK3β complex, possesses the superior effects on protecting against kidney aging. In D-gal-treated accelerated aging mice, KYA1797K could greatly inhibit β-catenin pathway, preserve mitochondrial homeostasis, repress cellular senescence, and retard age-related kidney fibrosis. In cultured proximal tubular cells, KYA1797K shows a better effect on inhibiting cellular senescence and could better suppress mitochondrial dysfunction and ameliorate the fibrotic changes, at the same dose as that in ICG-001. Conclusion: These results show that effectively eliminating β-catenin is a necessity to target against age-related kidney injury, suggesting the multiple transcriptional regulation of β-catenin in kidney aging besides T-cell factor/lymphoid enhancer-binding factor family of transcription factors (TCF/LEF-1).