bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Blockchain Lightweight Authentication Technology for Industrial Internet of Things
Authors: Zhao Mingrui , Shi Chunjing , Yuan Yixiao
Published: October 2023

Industrial Internet of Things (IIoT), as an important subset of the Internet of Things, is increasingly being applied in industrial production. Cross-domain trustworthy authentication between IIoT devices in different management domains is crucial for safeguarding sensitive data security of on-site equipment. To address the issues of resource consumption and low efficiency in traditional blockchain consensus mechanisms, this paper proposes a Reputation-based Lightweight Consensus Mechanism (LRBCM) tailored for distributed network structures in industrial IoT. LRBCM algorithm is designed based on node reputation values, enabling fast and accurate completion of the ledger consensus process while reducing communication overhead and computational complexity, thus achieving the goal of lightweight consensus. Furthermore, building upon this lightweight consensus mechanism, we introduce the Distributed Lightweight Authentication Mechanism (ELAM) based on Elliptic Curve Cryptography (ECC) to address device trustworthiness authentication concerns. Leveraging this authentication mechanism, we devise intelligent lightweight transaction identity authentication smart contracts. Finally, comprehensive research and analysis of the proposed mechanisms' performance are conducted through experimental results.
Deciphering Mutational Signature Dynamics in Hormone-Sensitive Breast Cancer During Treatment Adaptation.
Authors: Magnani Luca , Ivanoiu Diana , Rosano Dalia , slaven neil , Sofyali Emre , barozzi Iros , James Chela , Cresswell George , Corleone Giacomo , dhiman Heena , Singh Anup , Ali Simak , Sottoriva Andrea , Ramazzotti Daniele
Published: October 2023

The DNA accumulates somatic changes before and after tumor initiation. These changes have been classified into mutational signatures (1) but only recently have studies begun to experimentally validate and functionally dissect these signatures. The role of the underlying functional annotation of DNA and long-term exposure to endocrine therapies in shaping signatures in breast cancer remains to be elucidated. In this study we use novel patients- and in vitro-derived longitudinal datasets to dissect the dynamic nature of mutational processes throughout the evolution of hormone-sensitive breast cancer. We demonstrate that chromatin and epigenetic cues can actively shape the local mutational processes, with significant impact on regulatory elements and cancer drivers. We also conclude that the etiology of APOBEC and clock-like SBS5 signatures needs further experimental corroboration. In conclusion, our research illuminates the dynamic nature of mutational processes and their direct influence on tumor evolution
Social Support and Self-management Behavior and Quality of Life among Rural People with Type 2 Diabetes in Eastern China: The Mediating Role of Self-efficacy
Authors: Wang Lizhu , Qiu Yang , Li Sihan , Li Li , Wang Zhonghua
Published: October 2023

BACKGROUND
Type 2 diabetes (T2D) patients in rural China often demonstrate inadequate diabetes self-management (DSM) and a lower quality of life (QoL). Social support and self-efficacy can directly influence DSM or QoL. However, the mediating effect of self-efficacy on social support and DSM and social support and QoL among Chinese rural T2D patients remains unclear.
METHODS
Based on a survey among rural T2D Patients in eastern China, we employed structural equation modeling (SEM) to explore the direct and indirect influences of social support on DSM and QoL and to investigate the mediating role of self-efficacy.
RESULTS
It was found that the DSM score was less than half of the maximum theoretical score. The dimension of medication adherence behaviors exhibited the highest score (5.92) and blood glucose monitoring behaviors showed the lowest score (1.23). The QoL score accounted for 36% of the maximum theoretical score. The dimension of social relationships demonstrated the lowest score (1.33) and physiological function garnered the highest score (2.03). Social support directly and positively affected the DSM and QoL of Chinese rural T2D patients and exhibited an indirect positive influence mediated by self-efficacy. The mediating effect of self-efficacy accounted for 30.2% and 28.6%, respectively, of the total effect of social support on DSM and QoL.
CONCLUSIONS
The study confirmed the direct and indirect influences of social support on DSM and QoL and elucidated the mediating effect of self-efficacy. Interventions aimed at both fostering social support and self-efficacy should be developed to create a positive cycle of mutual reinforcement to improve DSM and QoL among rural T2D patients.
What is the meaning of LGE in right ventricle insertion points in pulmonary arterial hypertension? – a PET/MRI study
Authors: Kazimierczyk Remigiusz , Szumowski Piotr , Nekolla Stephan G. , Malek Lukasz A. , Blaszczak Piotr , Hladunski Marcin , Sobkowicz Bozena , Mysliwiec Janusz , Kaminski Karol A.
Published: October 2023

Presence of late gadolinium enhancement (LGE) in right ventricle insertion points (RVIPs) has been found in majority of pulmonary arterial hypertension (PAH) patients and is often recognized as evidence of myocardial fibrosis. The aim of the study was to evaluate the relationship between LGE mass and myocardium metabolic activity in RVIPs using PET/MRI imaging.
Twenty-eight clinically stable PAH patients had PET/MRI scans during baseline and 2-year follow up (FU) visits. Fluorodeoxyglucose cardiac uptake was assessed in the area of LGE (SUVRVIPS). Clinical end-point (CEP) was defined as death or clinical deterioration.
Mean LGE mass in RVIPs was 6.67±4.41 g and mean SUVRVIPS was 7.28±5.36. FU values were 8.01±7.75 g (p=0.27) and 5.81±3.16 (p=0.16), respectively. Decrease of SUVRVIPS was observed in 70% (n=14) cases. No statistically significant correlation was found between LGE mass and SUVRVIPS (in both baseline and FU scans).
PAH therapy have an impact on both LGE mass and FDG uptake in cardiac local tissue changes. Lack of reverse correlation between those two parameters suggests that LGE is not less metabolically active than the surrounding myocardium and hence it is unlikely to be simple fibrotic change, however this finding requires further studies.
Trial Registration: Clinical Trials.gov; NCT03688698, 09/26/2018, retrospectively registered; Protocol ID: 2017/25/N/NZ5/02689l https://clinicaltrials.gov/ct2/show/NCT03688698
Automatically listing senior members of departments as co-authors is highly prevalent in the health sciences: meta-analysis of survey research
Authors: Reynders Reint A. Meursinge , Cavagnetto Davide , Riet Gerben ter , Girolamo Nicola Di , Malički Mario
Published: October 2023

A systematic review with meta-analysis was conducted to assess the prevalence of automatically listing (a) senior member(s) of a department as co-author(s) on all submitted articles in health sciences and the prevalence of various justifications for doing so. Survey research was searched in PubMed, Lens.org, and Dimensions.ai. until January 5 2023. We assessed the methodological quality of studies and conducted quantitative syntheses. We identified 15 eligible surveys, that provided 67 results, of which all were rated as having low quality. A pooled estimate of 20% [95% CI 16–25](10 surveys, 3,619 respondents) of researchers in various health sciences reported that a senior member of their department was automatically listed as an author on all submitted articles. Furthermore, 28%[95% CI 22–34] of researchers (10 surveys, 2,180 respondents) felt that this practice was ‘never’, 24%[95% CI 22–27] ‘rarely’, 25%[95% CI 23–28] ‘sometimes’, 13%[95% CI 9–17] ‘most of the time’, and 8%[95% CI 6–9] ‘always justified’. The practice of automatically assigning senior members of departments as co-authors on all submitted manuscripts is common in the health sciences and yet those who conduct it do not find it justified in most cases. Increasing awareness of authorship guidelines, or credit taxonomies may help alleviate these issues. Registration of the protocol. The protocol was registered in Open Science Framework. Link: https://osf.io/4eywp/
Inhibition of KDM6A Decreased the Reactive Astrocytes Proliferation Induced by Hypoxic and Ischemic
Authors: Feng Chenxi , Xu Lixiao , Liu Qin , Li Mei , Feng Xing
Published: October 2023

HIBD (hypoxic-ischemic brain damage) is a common clinical problem, which is often accompanied by serious sequelae. This disease affects the life quality of patients and increases the economic burden on sufferers’ families. Many precipitating factors of HIBD have been studied, but its specific pathogenesis has not been thoroughly explored. Reactive astrogliosis is ubiquitous in HIBD and performs a variety of pathological and physiological functions. KDM6A (lysine-specific demethylase 6A) is a member of the α-ketoglutarate dioxygenase superfamily, and prolyl hydroxylase (PHD) of HIF (hypoxia-inducible factor) also belongs to this family. In this study, we focused on the role of KDM6A in the proliferation of reactive astrocytes. Astrocytes proliferated with KDM6A increased were found in the ischemic lateral brain of HIBD rats. After OGD/R (oxygen-glucose deprivation/ reoxygenation), KDM6A was significantly up-regulated, which accompanies astrocytes proliferation mediated by the imbalance of cell cycle regulation. While knockdown of KDM6A restored astrocytes proliferation and reversed pathological damage in the brain of HIBD-model rats. Transcriptome and qRT-PCR datum showed that KDM6A might contribute to post-transcriptional levels of the cell cycle pathway through the proteasome pathway (KO03050). Inhibitors of the proteasome pathway, MG-132, and Bortezomib (PS-341), could significantly up-regulate the expression of cyclin proteins after KDM6A knock-down. To sum up, this study suggested that KDM6A accelerates ischemia-hypoxia-induced astrocyte proliferation by regulating proteolysis of the cell cycle pathway. This study provides a new idea on dealing with reactive astrogliosis and novel possible evidence for the prevention and treatment of HIBD.
OncoReport: a system for integrative NGS analysis in precision medicine
Authors: Pulvirenti Alfredo , Privitera Grete Francesca , Alaimo Salvatore , Micale Giovanni , Giaimi Luca , Mare Marzia , Martorana Emanuele , Villa Riccardo , Ferro Alfredo , Forte Stefano
Published: October 2023

Objective: Next Generation Sequencing (NGS) has evolved into a mature technology that is becoming increasingly prevalent in the clinical setting. However, one of the significant challenges physicians and oncologists face is effectively handling the vast amount of genome-scale data generated by NGS experiments and translating it into actionable insights to support complex clinical decision-making. Several commercial systems have been developed to achieve this crucial goal, aiming to synthesize relevant information from custom and targeted NGS experiments. These systems generate comprehensive reports detailing prognosis and treatment possibilities. Unfortunately, a notable limitation of many existing tools is their closed-source nature, which restricts access to the underlying algorithms and hinders transparency. Furthermore, some of these systems do not leverage publicly available data, limiting their ability to tap into the vast pool of valuable genomic information collected by various databases. Another essential improvement aspect is the lack of flexibility in using different NGS panels. Each clinical scenario may demand a specific set of genetic markers, and a rigid tool that cannot adapt to different panel configurations may not effectively address the diverse needs of patients and clinicians.
Results: To overcome these challenges, in this paper, we present OncoReport, an innovative open-source tool designed to generate comprehensive reports derived from Next-Generation Sequencing (NGS) analysis, seamlessly integrating data from various freely-accessible databases. By providing a robust environment equipped with a wide range of software and tools essential for conducting a thorough NGS analysis, OncoReport emerges as a powerful solution for clinicians seeking to enhance data interpretation and decision-making processes. Through rigorous testing and validation, we demonstrate the effectiveness of OncoReport's pipeline in generating rich, informative reports that are easy to comprehend and utilize. Indeed, OncoReport significantly reduces the manual effort required for data synthesis, thereby expediting the analysis and interpretation of NGS results. Our findings underscore the invaluable role of OncoReport in fostering a more efficient and reliable framework for clinicians to access, comprehend, and apply genomic insights to patient care.
Availability: OncoReport is freely available for download at the following URL https://oncoreport.atlas.dmi.unict.it. Source code and issue reporting are available at https://github.com/knowmics-lab/oncoreport.
Using joint species distribution modelling to predict distributions of seafloor taxa and identify vulnerable marine ecosystems in New Zealand waters
Authors: Stephenson Fabrice , Bowden David A , Rowden Ashley A , Anderson Owen F , Clark Malcolm R , Bennion Matthew , Finucci Brittany , Pinkerton Matt H , Goode Savannah , Chin Caroline , Davey Niki , Hart Alan , Stewart Rob
Published: October 2023

Effective ecosystem-based management of bottom-contacting fisheries requires understanding of how disturbances from fishing affect seafloor fauna over a wide range of spatial and temporal scales. Using an extensive dataset of faunal abundances collected using a towed camera system, with spatially explicit predictor variables including bottom-trawl fishing effort, we developed spatial predictions of abundance for 67 taxa using Hierarchical Modelling of Species Communities. The model fit metrics varied by taxon: the mean ten-fold cross-validated AUC score was 0.70 ± 0.1 (standard deviation) for presence-absence and an R2 of 0.11 ± 0.1 (standard deviation) for abundance models. Spatial predictions of probability of occurrence and abundance (individuals per km2) varied by taxon, but there were key areas of overlap, with highest predicted taxon richness in areas of the continental shelf break and slope. The resulting joint predictions represent significant advances on previous predictions because they are of abundance, allow the exploration of co-occurrence patterns and provide credible estimates of taxon richness (including for rare species that are often not included in community-level species distribution assessments). Habitat-forming taxa considered to be Vulnerable Marine Ecosystem (VME) indicators (those taxa that are physically or functionally fragile to anthropogenic impacts) were identified in the dataset. Spatial estimates of likely VME distribution (as well as associated estimates of uncertainty) were predicted for the study area. Identifying areas most likely to represent a VME (rather than simply VME indicator taxa) provides much needed quantitative estimates of vulnerable habitats, and facilitates an evidence-based approach to managing potential impacts of bottom-trawling.
Should social withdrawal be held responsible for social media addiction? The chain mediating effect of alexithymia and negative body image
Authors: Li Shuang , Liu Li-li , Sun Chongyong
Published: October 2023

To explore the influence of social withdrawal on college students' addiction to social media and its underlying mechanisms.Using the Middle School Student Social Withdrawal Questionnaire, Social Media Addiction Questionnaire, Toronto Alexithymia Scale, and Negative Body Image Scale, 2582 college students (33.46% male, average age = 19.46 years, SD = 2.23) were surveyed.Social withdrawal, alexithymia, negative body image, and social media addiction were significantly correlated with each other.Social withdrawal positively predicted social media addiction, and both alexithymia and negative body image played a chain-mediating role between social withdrawal and social media addiction.Conclusion: Individual social withdrawal not only directly affects college students' addiction to social media but also indirectly affects it through the chain mediating effects of alexithymia and negative body image.
Development of Web Based Medical Equipment Inventory Maintenance System
Authors: Nwaneri Solomon , Olaoye Gabriel
Published: October 2023

Background and Purpose
The functionality of medical equipment is critical to quality healthcare delivery. With regular preventive maintenance, the usability and lifetime of medical equipment can be extended. Adherence to preventive maintenance schedule is challenging without a robust inventory management system. This paper presents a web based medical equipment inventory maintenance system (MEIMS) software.
Methods
The MEIMS software was developed using the waterfall model of software engineering methodology based on a 3-tier architecture comprising the graphical user interface, processor, and database server. The system consists of a user-friendly interface which ensured an effective and efficient medical equipment management with prompt maintenance schedule notification for the biomedical engineers. Data collected from a public hospital in Lagos, Nigeria were tested on the MEIMS software.
Results
The results revealed that the MEIMS software is user friendly and easy to use. The dashboard of the interface design indicates a summary of the total number of equipment, the total registered users, total medical equipment under repair, total equipment purchased, monitoring log, usage analysis, and inventory. the usage analysis interface design for new equipment and its daily usage input. It displays the total usage checks, percentage usage and indicates if the equipment was used that day.
Conclusions
This developed software was shown to be a helpful system for medical equipment workflow management to control asset, inventory, scheduled preventive maintenance, and corrective maintenance module.
Innovative Approach to Teaching EFL through a Game-based Speaking Mobile Application
Authors: Espiritu Jarah Gertrudes Mallillin , Buaraphan Khajornsak
Published: October 2023

Amidst the growing body of research on mobile game-based apps, there remains a dearth of studies investigating teacher-developed game-based mobile apps. Employing a research and development framework, this study delved into the development and implementation process of a mobile game-based app created by teachers, evaluated its effectiveness, and identified key features for enhancing speaking skills. The research encompassed three distinct phases: initial need analysis (involving 287 participants, including 123 high school students and 164 college students); subsequent design and implementation (incorporating 21st century skills, task-based language teaching, mobile-assisted language learning, automatic speech recognition, and gamification); and final implementation (involving 16 participants, comprising 8 high school students and 8 college students). Data collection was facilitated through surveys (for the need analysis and the Unified Theory of Acceptance and Use of Technology (UTAUT)), pre- and post-speaking tests, as well as interviews. Data analysis encompassed descriptive statistics, the Wilcoxon signed-rank test, the Mann-Whitney U-test, and thematic analysis. The findings unveiled high school and college students both strongly believed in the effectiveness of a teacher-developed mobile speaking app for improving English proficiency. The SPEAK APP significantly improved speaking skills for both groups of students, with an emphasis on fluency and pronunciation. Interviews revealed positive experiences, suggestions for enhancement, and boosted self-confidence. Essential features for improved speaking skills in mobile apps included encouraging thinking, sharing experiences, English communication, and interactive play with friends. While user friendliness was appreciated, concerns about response time and speech recognition accuracy emerged, and confidence improvement was noted. The study underscores the importance of creating student-perceived useful and engaging apps aligned with the UTAUT model, combining quantitative skill improvement assessments with qualitative user experience insights to guide developers to prioritize essential features and address usability challenges.
A Framework on Combining the Symptoms With Dissimilar Features to Predict Multiple Diseases Using Machine Learning Algorithms
Authors: Gantayat Sasanko Sekhar , Suru Chaitanya
Published: October 2023

Health plays a vital role in the well-being of individuals. However, due to busy schedules, people often neglect regular health checkups. Engaging in weekly or monthly health checkups is crucial for leading a longer and healthier life. Contemporary food habits, lifestyle choices, pollution, and other factors contribute to various health issues. Unfortunately, many individuals remain unaware of numerous diseases, unknowingly spreading them due to their negligence. A striking example is the COVID-19 pandemic, where people struggle to differentiate between COVID-19 symptoms and those of other illnesses. In such circumstances, technology emerges as a key player. Machine Learning, a field focused on computer algorithms that learn from past experiences, has gained widespread usage and proven to be highly effective in healthcare. This project aims to develop a model that leverages various Machine Learning Algorithms by training a combination of classifiers to create super learners and meta learners. A user-friendly Graphical User Interface (GUI) will be designed to collect symptoms from the user. By utilizing Machine Learning algorithms such as Support Vector Machines (SVM), decision trees, logistic regression, Naive Bayes, and boosting algorithms like AdaBoost and XGBoost, the model will predict the disease based on the symptoms provided by the user. This prediction will assist the user in identifying the potential illness they may be experiencing. As the saying goes, "Prevention is better than cure," and this project emphasizes the significance of early disease detection. It provides a detailed explanation of how the model identifies diseases based on different symptoms using various algorithms. Armed with this information, individuals can promptly contact the appropriate healthcare professionals and take proactive steps to maintain their well-being and overall health.
Performance Analysis of Mimo-dwdm Fso Systems Using Modulation Techniques Over Atmospheric Turbulence
Authors: ELSAYED EBRAHIM E.
Published: October 2023

This paper analyses and enhances a Multiple-Input Multiple-Output (MIMO) lasers of Dense Wavelength Division Multiplexing Free Space Optical Communications (DWDM-FSO) communication using the On-Off Keying (OOK) and Q-ary Pulse Position Modulation (QPPM) for atmospheric turbulence regime. The result obtained for MIMO-DWDM/FSO Q-ary QPPM/OOK increase and improves the performance with maximum 4dB.
Assessing the Communication Skills of Postgraduate Students in India
Authors: SWARGIARY KHRITISH
Published: October 2023

Effective communication skills are crucial for academic and professional success. This research study aimed to assess the communication skills of postgraduate students in India and identify potential areas for improvement. A sample of postgraduate students from various disciplines was selected, and their communication skills were evaluated using standardized assessment tools and experimental tasks. The findings revealed both strengths and weaknesses in the communication skills of the participants, highlighting the need for targeted interventions to enhance communication abilities among postgraduate students in India.
Assessing the Awareness of Students in India on the National Education Policy 2020
Authors: SWARGIARY KHRITISH
Published: October 2023

The National Education Policy (NEP) 2020 is a comprehensive framework that aims to transform the Indian education system to meet the challenges of the 21st century. It introduces several reforms and innovative approaches to enhance the quality and inclusivity of education. This research article explores the awareness of students in India regarding the NEP 2020. This research article investigates the awareness of students in India belonging to four different educational levels, namely K-12, undergraduate, postgraduate, and Ph.D. scholars, regarding the National Education Policy 2020 (NEP). The study aims to understand the level of awareness, perception, and engagement of students in these respective groups with the NEP 2020. A mixed-methods approach was utilized, combining surveys and interviews, to gather data on students' understanding, sources of information, and attitudes towards the policy. The findings provide insights into the awareness gaps and varying levels of engagement across the different educational levels, offering valuable implications for policymakers and educators to effectively implement the NEP 2020 reforms at each stage of education.
Evaluating Various Colors of Persistent Luminescent Powders on Rose Cut Flowers
Authors: Pace Abby , Dunn Bruce L. , Fontanier Charles
Published: October 2023

Rose cut flowers are popular in everyday bouquets or for special occasions, and tinting of the flowers by means of color addition increases the flowers economical value and aesthetic appeal. This study evaluated red and white luminescent rose cut flowers, which was achieved by applying six persistent luminescent powders. Solutions of each color were prepared by mixing 6 g of powder and 240 ml of deionized water and sprayed four times around the flower head plus a control. Images were taken of the flowers before ultraviolet blacklight exposure and after exposure to be later analyzed with ImageJ software. Daily measurements were taken including vase weight, average floral diameter, and visual deterioration based on scale of 1 to 4. Overall measurements included mean brightness; red, green, and blue measured values; dominant wavelengths of emitted color; flower diameter change rate; relative water percent; solution uptake rate; and vase solution uptake rate. For luminescent brightness mean without ultraviolet, white rose with blue powder had the greatest value. For luminescent brightness after ultraviolet exposure, white rose with green powder had the greatest value. With ultraviolet exposure, white roses with green powder had the greatest value followed by blue, orange, and white. Red powder on white and red roses experienced little to no luminescence before or after ultraviolet exposure. Mean and mode varied in their calculated dominant wavelengths; therefore, it is recommended to use mean values because more similarities in matching of the powder color and the calculated dominant wavelength were reported. Ultimately, white roses are preferred because they seemed to have greater health and luminescence compared with red roses, and green and blue powder would be recommended for luminescent application for brightness.
Factors influencing job stress: Evidence from tellers in Cambodia
Authors: Bostan Ali Wanamina , Kim Long , Pongsakornrungsilp Siwarit , Chinchanachokchai Sydney
Published: October 2023

Increasing the propensity for job stress can negatively affect individuals’ job satisfaction and work productivity. Therefore, lots of organizations have tried to assess factors that can affect job stress among workers so that they can seek to develop new working policies to promote a better working environment for their staff. This study aims to investigate how job stress is influenced by these key factors (i.e., workload, work-family conflict, role conflict, performance pressure, and supervisor support). To collect the data, 649 tellers who felt pressured and frustrated with their jobs were asked to fill in the self-administered questionnaires. Next, multiple regression was used to analyze the data. The results indicated that role conflict (β = 0.45), workload (β = 0.30), work-family conflict (β = 0.23), and supervisor support (β = –0.19) significantly influenced job stress among bank tellers. At the same time, performance pressure had an insignificant effect on job stress.
Factors Increasing Loyalty of Local Cosmetic Brands: A Study on Generation Z in Indonesia
Authors: Suwandi Dita Sari , Balqiah Tengku Ezni
Published: October 2023

The fierce competition in the beauty industry in Indonesia raises the problem of loyalty with various choices and information accessibility from the Internet. Issues also surface from Generation Z, recently reported to dominate the market as digitally savvy and tends to be disloyal to one brand. The research aimed to analyze the factors that increased brand loyalty in the local cosmetics industry, specifically from Generation Z in Indonesia, through brand love and the mediation effects of self-esteem, susceptibility to normative influence, and social media brand engagement. The research applied a quantitative approach by distributing online questionnaires and purposive sampling to 321 respondents. The data obtained were processed with Structural Equation Modeling (SEM) with Partial Least Square approach (PLS) using SmartPLS. The results show a direct relationship between brand love and brand loyalty, brand love with the mediating variables (self-esteem, susceptibility to normative influence, and social media brand engagement), and two dimensions of social media brand engagement (affective and behavioral social media brand engagement) with brand loyalty. The other two mediating variables, such as self-esteem and susceptibility to normative influence and behavioral social media brand engagement, do not affect brand loyalty. However, the mediating effect only exists through affective and behavioral dimensions in increasing brand love relationships with brand loyalty. The research contributes to Indonesia’s business practitioners retaining their consumers amid intense competition by utilizing affective and behavioral factors in giving information on social media.
Covıd-19 Pandemi Süreci İçin Üretilen Çalışmaların Görsel Algıya Etkisinin Kavramsal Tasarım Yaklaşımıyla Değerlendirilmesi
Authors: BİROL Emel
Published: October 2023

Covid-19 pandemi sürecinde, ülkeler, toplumu bilgilendirmek ve onları önlemler konusunda bilinçlendirmek için her alanda önemli sorumluluklar üstlenmiştir. Bu süreçte, yayınlanan fotoğraflar, videolar, sosyal medya postları, afişler, infografikler vb. görsel odaklı çalışmaların önemi daha fazla ön plana çıkmıştır. Bahsedilen bu görsel çalışmalardan özellikle kavramsal tasarım yaklaşımının ele alındığı çalışmaların, bilginin kolay öğrenilebilir olmasında etken bir rol oynadığı söylenebilir. Kavramsal tasarımlar, bir olay, düşünce veya durumu simgeleyen görsellerdir. Bu kapsamda, kavramsal tasarım yaklaşımı ile Covid-19 pandemi süreci için alanında uzman kişiler tarafından tasarım çalışmaları hazırlanmıştır. Hazırlanan tasarımların izleyicilerde, farkındalık yaratma ve görsel algı üzerindeki etkilerini sosyo-demografik değişkenler açısından araştırmak amacıyla 422 katılımcı ile bir anket çalışması yürütülmüştür. Anket çalışması için İstanbul Gedik Üniversitesi Etik Kurulundan 09.11.2022 tarih ve E-56365223-050.01.04-2022.137548.13-387 sayısıyla gerekli izin alınmıştır. Ana kütlesi, İstanbul’daki üniversitelerde çalışan idari ve akademik personel ile eğitim gören öğrenciler olan çalışmaya, yargısal örnekleme yöntemi ile seçilen İstanbul Anadolu yakasındaki vakıf üniversitelerinde çalışan idari ve akademik personel ile öğrenciler dâhil edilmiştir. Çalışmada betimsel ve bağıntısal tarama yöntemi kullanılmış ve çalışmanın verileri, alanında uzman kişiler tarafından Covid-19 salgını için kavramsal tasarım yaklaşımı ile oluşturulmuş tasarımlar üzerinden görsel tasarım ilkeleri ve görsel tasarım elemanları bağlamında iki boyutta toplanmıştır. Her iki boyuta ait verilerin analizleri, SPSS yazılımında “t testi” ve “ANOVA” testleri ile yapılmıştır. Analizler sonucunda her iki boyuta ait istatiksel değerlerde katılımcıların sosyo-demografik özellikleri ile görsel algılarının etkilendiği tespit edilmiştir.
Perakende Marka Deneyiminin Marka Tatmini, Marka Bağlılığı ve Ağızdan Ağıza İletişime Etkisi: Decathlon Markası Örneği
Authors: BİCAL Adil
Published: October 2023

Modern tüketici dünyasında bireyler, alışverişleri sırasında ürünlerin sadece faydacı özelliklerine değil, aynı zamanda hedonik ve deneyimsel yönlerine de öncelik vererek içsel tepkilerini ortaya koyma eğilimi göstermektedir. Bu durum hem sektördeki uygulayıcılar hem de akademisyenler arasında marka deneyimine yönelik ilginin artmasına yol açmıştır. Ürünlerin ve hizmetlerin işlevsel yönlerinin yanı sıra hedonik özellikleri de zenginleştirilerek alışveriş sürecinin deneyimsel boyutu artırılmaktadır. Diğer yandan perakende sektörü, müşteri etkileşimini zorunlu kıldığından, müşteri deneyimi önemli bir faktör olarak ön plana çıkmaktadır. Müşterilerin marka ile etkileşim noktaları çeşitlilik göstermektedir. Mağaza atmosferi, müzik, renk, koku, görsel tema ve çalışanlar gibi çevresel uyaranlar, müşteriler üzerinde belirgin bir etki yaratmaktadır. Müşterinin mağazada geçirdiği süre içerisinde karşılaştığı fiziksel uyarıcılar, duygusal ve bilişsel sonuçlara yol açmaktadır. Bilişsel ve duygusal beklentilerin karşılanması, müşteri tatminini artırarak tekrar satın alma olasılığını yükseltmektedir. Bu çalışma, marka deneyiminin müşteri tatmin algısı üzerindeki etkisini, bunun marka bağlılığı ve ağızdan ağıza iletişime etkisini incelemeyi amaçlamaktadır. Bu amaç doğrultusunda, Decathlon mağazasını ziyaret eden tüketicilerin marka deneyimleri incelenmiştir. Araştırma sonuçları, marka deneyimi ile müşteri tatmini arasında güçlü bir ilişkinin varlığını kanıtlamaktadır. Benzer şekilde, marka deneyimi marka bağlılığını olumlu yönde etkilemektedir. Sonuçlar, ağızdan ağıza iletişim ile marka bağlılığı arasında ve ağızdan ağıza iletişim ile marka deneyimi arasında pozitif yönlü bir ilişki olduğunu göstermektedir. Bununla birlikte, araştırma müşteri tatmini ile marka bağlılığı arasındaki beklenen ilişkiyi doğrulayamamıştır. Bu çalışma, perakende sektöründeki şirketlere müşteri deneyimi yönetimi stratejileri konusunda önemli öneriler sunarken, müşteri tatminin her zaman marka bağlılığı yaratmadığını vurgulamaktadır.
1946 Genel Seçimleri: Adana (Seyhan) Örneği
Authors: ÖZER Sevilay
Published: October 2023

7 Ocak 1946’da Demokrat Parti (DP)’nin kuruluşu, Türk demokrasi tarihi açısından yadsınamayacak bir önem taşır. II. Dünya Savaşı’nı demokrasi cephesinin kazanmasının etkisiyle savaş yıllarında olgunlaşan muhalif hareket, 1946 yılında DP’nin kurulmasıyla sonuçlanmıştır. 1945 yılında Milli Kalkınma Partisi kurulmuş olsa da gerçek anlamda iktidara alternatif bir muhalefet partisi olma özelliğini yakalayamaz. 1947 yılında yapılacak olan genel seçimlerin 1946 yılına çekilmesi iktidar-muhalefet ilişkilerini gerginleştirirken, 21 Temmuz 1946’da gerçekleşen bu seçimlerin “şaibeli” seçimler olarak öne çıkması, siyasi hayatta daha büyük tartışmaları beraberinde getirmiştir. Tüm bu tartışmalara rağmen 1946 Genel Seçimleri Türk demokrasisi adına bir dönüm noktasıdır. 5 Haziran 1946 tarihinde kabul edilen yeni seçim kanunu ile tek dereceli olarak yapılan seçimlerde açık oy gizli sayım, liste usulü çoğunluk sistemi uygulanmıştır. Oldukça hareketli bir siyasi atmosfer içerisinde gerçekleşen seçimler hem seçmen hem de partiler adına önemli bir deneyimdir. DP bu seçimlerde uygulanan usulsüzlükleri muhalefette kaldığı süre zarfında sıklıkla dile getirdiği gibi 1950 Genel Seçimleri öncesi seçim meydanlarına da taşımıştır. Çalışmamızda Adana özelinde 1946 Genel Seçimlerinin uygulanış süreci; seçim çalışmaları, partilerin birbirleriyle olan rekabeti ve seçim sonuçları irdelenmeye çalışılmıştır.
Ermeni Meselesinin Ortaya Çıkışı ve İran Basınındaki Yansımaları
Authors: KAYA Yakup
Published: October 2023

Uzun bir tarihsel geçmişe sahip olan Ermenilerin menşei ve yaşadıkları coğrafya ile ilgili gerek Ermeni tarihçiler gerekse de diğer tarihçiler arasında herhangi bir ittifak söz konusu değildir. Ermeniler, birçok coğrafyada farklı yönetimlerin hâkimiyetinde yaşamışlardır. Fatih Sultan Mehmet döneminde Ermeniler için Patrikhane kurulmuş, Yavuz Sultan Selim ve Kanuni Sultan Süleyman dönemlerinde de fethedilen yerlerdeki Ermeniler, büyük topluluklar halinde İstanbul’a yerleştirilmişlerdir. 1821 yılındaki Rum İsyanından sonra Rumların yerine getirdiği birçok devlet görevi Ermenilere verilmiştir. Ermeniler yaklaşık beş yüz yıl boyunca Osmanlı topraklarında diğer milletlerle barış içerisinde yaşamış ve ‘Millet-i Sadıka’ olarak isimlendirilmişlerdir. 1877-1878 yıllarında yapılan Osmanlı-Rus savaşını Rusya’nın kazanması sonucunda yabancı devletlere Osmanlı topraklarına müdahale etme hakkı tanınmış ve Ermeni meselesi uluslararası bir sorun haline gelmiştir. Bundan sonra Ermenilerin, Osmanlı topraklarında yaptıkları isyanlarda İran Devleti, Ermenileri birçok açıdan desteklemiştir. Hınçak, Taşnak ve Armenakan gibi Ermeni cemiyetleri İran’da örgütlenmişlerdir. İran Hükümeti İran konsoloslukları vasıtasıyla Ermenilerin rahat hareket edebilmeleri ve zor durumda kaldıklarında kaçabilmeleri için İran pasaportu vermiştir. İran basını Ermeni meselesinde yanlı yayınlar yapmıştır. İran basınında Ermeni olayları ile ilgili verilen haberler, Ermenilerin büyük bir katliama uğradıkları şeklinde olmuştur. Bu çalışma ile Ermeni meselesinin ortaya çıkmasıyla beraber yaşanan olayların, İran basınında ele alınış biçimi incelenerek konuyla ilgili yapılacak araştırmalara katkı sunmak amaçlanmıştır.
Überprüfung der Einführung des Zweikammersystems im Gemeinderat
Authors:   European Constitutional Law Association, Chang Young-Soo
Published: October 2023

In verschiedenen Aspekten wird versucht, die Dezentralisierung zu stärken. In den meisten Fällen lassen sich Diskussionen über die Verteilung der Befugnisse zwischen der Zentralregierung und den lokalen Regierungen jedoch nicht vermeiden, und in vielen Fällen wird der Zusammenhang mit der praktischen Bedeutung von Dezentralisierung oder lokaler Autonomie vernachlässigt. Wenn die lokale Regierung lediglich eine Miniaturversion der Zentralregierung ist, wird die praktische Bedeutung der lokalen Autonomie unweigerlich verblassen.
Aus diesem Grund sollten wir den Kommunalräten bei der jüngsten Entwicklung der Kommunalautonomie Aufmerksamkeit schenken. So wie die Zentralregierung mit verschiedenen Problemen mit dem kaiserlichen Präsidenten konfrontiert ist, gibt es einen Punkt, an dem die lokale Autonomie aufgrund der Machtkonzentration beim kaiserlichen Oberhaupt der lokalen Regierung nicht verwirklicht wird. Mittlerweile haben die Kommunalräte aus verschiedenen Gründen kein Vertrauen bei den Anwohnern. Es besteht jedoch kein Zweifel darüber, dass die Gemeinderäte ordnungsgemäß funktionieren müssen, um einen neuen Schritt nach vorn in der kommunalen Autonomie zu machen.
Im gleichen Zusammenhang ist zu sehen, dass auch im Zusammenhang mit der Entwicklungsrichtung der Kommunalräte Diskussionen über die Einführung des Zweikammersystems begannen. Dies ist ein ganz neuer Versuch und bietet die Gelegenheit für bahnbrechende Veränderungen in den Gemeinderäten. Allerdings muss auf die Geschwindigkeitskontrolle geachtet werden, damit diese Versuche nicht zu sehr der Zeit voraus sind. Bisher stagnierten die Diskussionen über die Einführung eines Zweikammersystems in der Nationalversammlung. Die vorzeitige Einführung des Zweikammersystems durch die Kommunen dürfte nicht nur kaum gelingen, sondern auch, weil die politische Belastung sehr groß sein wird.
Daher halte ich es für richtig, die heutige Diskussion über die Einführung des Zweikammersystems in den Gemeinderäten als Teil einer schrittweisen Vorbereitung auf mittel- bis langfristige Aufgaben und nicht als Lösung kurzfristiger Aufgaben zu verstehen. Egal wie gut das System ist, der Versuch, es vor dem richtigen Zeitpunkt einzuführen, führt dazu, dass die Nebenwirkungen größer sind.
|A descoberta das Europas: a literatura de viagens, a geografia, a história e a evolução da identidade europeia (séculos XVI-XVIII)
Authors: Clara Fernando
Published: October 2023

The text seeks to reconstruct the dynamics of the evolution of European identity throughout the 18th century. Starting with two 16th and 17th century maps of Europe (popularized by Sebastian Münster and Willem Janszoon Blaeu), it analyses a wide range of works (compendia of history and geography, essays, satires, travel accounts) that focus on Europe and the Europeans, and which are implicitly or explicitly based on the travel literature of the time. From the discovery of an Imperial Europe to the discovery of the ‘national’ diversities of the European peoples, without forgetting the discovery of a Europe inhabited by ‘European savages’, the identitarian evolution that the analysis suggests points to a European identity that is doubly marked by mobility: marked by travel and the knowledge of the world provided by travel writing, which is the touchstone from which Europe seeks to define itself, and also marked by the perspectivism that travel introduces into the ways of seeing and being European.
КЛІНІЧНИЙ ВИПАДОК ГОСТРОГО КОРОНАРНОГО СИНДРОМУ У ПАЦІЄНТА З АНЕВРИЗМАТИЧНИМ РОЗШИРЕННЯМ КОРОНАРНИХ СУДИН
Authors: Томин Ігор , Федоров Сергій , Луцак Ігор , Остафійчук Оксана , Мосур Михайло , Рейтмаєр Любомир , Шевчук Мар'яна
Published: October 2023

Аневризма коронарних артерій (АКА) характеризується аномальним дифузним або локальним розширенням сегментів коронарного артеріального дерева. Це явище також називають коронарною ектазією або дилатаційним артеріосклерозом. Показано, що наявність розширених коронарних сегментів, навіть за відсутності обструктивного захворювання, обумовлює порушення кровотоку і стаз, що може призводити до ішемії міокарда та інфаркту міокарда. Метою дослідження є представити клінічний випадок гострого болю в грудній клітці, який розвинувся на тлі аневризматичного поширення вінцевих артерій. Пацієнт 68 років, доставлений бригадою ШМД у відділення екстреної невідкладної допомоги лікарні з приводу тиснучого, пекучого загруднинного болю з іррадіацією в спину, що тривав більше 20 хвилин з діагнозом гострого коронарного синдрому. За результатами проведення ургентної коронароангіорафії виявлено гостру оклюзію правої коронарної артерії (ПКА) тромботичними масами та аневризматичні поширення коронарних артерій. Проведено аспірацію тромботичних мас з ПКА. Після процедури пацієнт у стабільному стані перебував у блоці інтенсивної терапії, де отримував стандартну терапію, згідно з уніфікованим клінічним протоколом та міжнародиними рекомендаціями. Дослідження показали, що приблизно 50% АКА викликані атеросклерозом, 20-30% - вродженими порушеннями, а 10%-20% - запальними захворюваннями або захворюваннями сполучної тканини, такими як хвороба Кавасакі, артеріїт Такаясу, системний червоний вовчак або ревматоїдний артрит. Генетична схильність також може бути залучена до формування АКА та ектазії коронарної артерії. Дискусійним є питання, чи може викликати перенесений COVID-19 у тому числі з безсимтомним перебігом. Вплив COVID-19 на судинну біологію останнім часом привертає велику увагу, оскільки він, як видається, є причиною значного відсотка негативних наслідків. У хворих на АКА стентування на тлі гострого інфаркту міокарда може бути відкладено через підвищений ризик no-reflow та неповного встановлення стента з наступним рестенозом. Також розглядається хірургічне лікування АКА, яке полягає у висіченні та перев’язці аневризматично поширених вінцевих артерій та подальшим аорто-коронарним шунтуванням (АКШ). Аневризми коронарних артерій є рідкісною знахідкою при проведенні коронароангіографій у пацієнтів з гострими та хронічними коронарними синдромами. Потребує вивчення зв’язку з перенесеним COVID-19 та довготривалих наслідків після госпіталізації.
Нестероїдні антагоністи мінералокортикоїдних рецепторів та кардіоренальний контінуум
Authors: Боцюрко Юрій
Published: October 2023

Антагоністи мінералокортикоїдних  рецепторів (АМКР), такі як спіронолактон та еплеренон, використовуються в лікуванні пацієнтів із хронічною серцевою недостатністю (ХСН) зі зниженою фракцією викиду та резистентною гіпертензією. Однак пов'язаний з цим ризик гіперкаліємії та ряду побічних ефектів обмежує їх широке застосування у пацієнтів високого ризику з цукровим діабетом  (ЦД) 2 типу  та хронічною хворобою нирок (ХХН). Недостатня ефективність цієї терапії у такої категорії пацієнтів викликала необхідність розробки нового класу сполук. Фінеренон є новим нестероїдним АМКР, який нещодавно отримав схвалення FDA щодо кардіоренопротекції пацієнтів із ХХН, пов'язаною з ЦД 2 типу. Результати клінічних випробувань фази 3, FIDELIO-DKD і FIGARO-DKD, продемонстрували, що у пацієнтів з цукровим діабетом 2 типу з різними стадіями ХХН фінеренон знижує ризик проявів серцево-судинної та ниркової недостатності в порівнянні з плацебо, з мінімальним ризиком гіперкаліємії. Ці дослідження показали, що профіль ефективності та безпеки фінеренону був подібним до інгібіторів натрій-залежного котранспортера глюкози типу 2 (НЗКТГ-2). Чи є комбінація фінеренону з інгібітором НЗКТГ-2 більш корисною для пацієнтів з ЦД 2 типу та ХХН в поєднанні з різними фенотипами ХСН порівняно з стандартною терапією, є важливим питанням, яке в даний час досліджується в поточних клінічних дослідженнях.

Ключові слова: спіронолактон, еплеренон, фінеренон, нестероїдні АМКР, ХХН, ЦД 2 типу, ХСН.

Mineralocorticoid receptor (AMCR) antagonists such as spironolactone and eplerenone  are used in the treatment  of patients with chronic heart failure (CHF) with reduced ejection fraction  and  resistant hypertension. However, the associated risk of hyperkalemia and a number of side effects limits their widespread use in high-risk patients with type 2 diabetes mellitus and chronic kidney disease (CKD). The lack of efficacy of this therapy in this category of patients  necessitated  the development of a new class of compounds. Finerenone is a novel nonsteroidal AMCR  that has recently received FDA approval  for cardiorenal protection in patients with CKD associated with type 2 diabetes. The results of phase 3 clinical trials,  FIDELIO-DKD and FIGARO-DKD, demonstrated that in patients  with type 2 diabetes mellitus with different stages CKD, finerenone reduces the risk of  cardiovascular and renal failure compared with placebo, with minimal risk of hyperkalemia.  These studies showed that the efficacy and safety profile of finerenone was similar to that of sodium-dependent glucose  transporter type 2 (SGLT-2). Is the combination of finerenone with an SGLT-2 inhibitor  more beneficial in patients with type 2 diabetes and CKD, combined with different phenotypes of CHF compared to standard therapy, is an important issue that is currently under investigation in ongoing clinical studies.

Keywords: spironolactone, eplerenone, finerenone, nonsteroidal AMCR, CKD,  type 2 diabetes mellitus, CHF.