bluuebunny/crossref_metadata_2025 huggingface dataset:
Architectonic Design Supported by Visual Environmental Simulation—A Comparison of Displays and Formats
Authors: Higuera-Trujillo Juan Luis , López-Tarruella Maldonado Juan , Castilla Nuria , Llinares Carmen
Published: January 2024

Visual environmental simulations are fundamental in understanding the relationship between the built environment and psychological perception. The remarkable evolution of virtual immersion displays over recent years has provided a series of advantages to the architectural discipline, one of which is that non-specialists now have the potential to better understand architectural spaces. This work aimed to analyse the adequacy of the main displays and formats currently used in environmental simulations. As the objective was twofold, two experimental studies were carried out (with a sample of 100 participants). The studies evaluated users’ responses to different environmental representations of two environments, using differential semantic scales to measure key underlying factors (utility, credibility, realism, accuracy, abstraction). The first study examined simulation displays: a PC, an HTC Vive Pro 2 head-mounted display, a PowerWall Screen and a CAVE. In the second, formats were analysed: normal image, 360° image, video and 360° video. The results of this work revealed that users perceived the space differently depending on the representation displays and formats used. Such comparisons of these new means of representing architectural spaces can be helpful to researchers, architects and urban planning professionals and might provoke debate in, and be extrapolated into, the design field.
Effect of Expansion Agent and Glass Fiber on the Dynamic Splitting Tensile Properties of Seawater–Sea-Sand Concrete
Authors: Zhu Huanyu , Xiong Zhe , Song Yuying , Zhou Keting , Su Yue
Published: January 2024

In marine structural engineering, the impact resistance of concrete holds high significance. The determination of whether the combined use of expansion agent (EA) and glass fiber (GF) has a synergistic effect on the impact resistance of seawater–sea-sand concrete (SSC) and plays a role in its performance and application. In this study, the dynamic Brazilian disc test at various strain rates was carried out with an SHPB device to investigate the effect of mixing 0% and 6% EA with 0% and 1% GF on the dynamic splitting tensile properties of SSC. The results show that strain rate effect on EA and GF-reinforced SSC during dynamic splitting tensile tests at higher strain rates, indicating strong strain rate sensitivity. The synergistic reinforcement of EA and GF consumed more energy under impact loading, thus maintaining the morphological integrity of concrete. However, the dynamic splitting tensile strength obtained in the Brazilian disc test had a significant overload effect which cannot be ignored. EA doped at 6% and GF doped at 1% showed a synergistic enhancement of SSC’s dynamic splitting tensile properties.
Inertial Measurement Unit- and Time Series Approach-Based Motion Trajectory Reconstruction of the Safety Rope Fastening Behaviour
Authors: Han Zixin , Wang Yaowu
Published: January 2024

Monitoring workers’ safety compliance is critical to construction accident prevention. However, most of the previous research focuses on checking the entry of workers wearing safety belts and the monitoring of the fastening action of safety rope screw buckles has not yet been considered. In this paper, a reconstruction method for the safety rope fastening behaviour of workers is proposed based on inertial measurement units (IMU) and a time series approach to monitor safety belt use. The proposed method was applied and evaluated through on-site construction experiments. The experimental results show that the acceleration, angular velocity, and magnetic induction intensity data obtained by the inertial measurement unit exhibit clear behavioural characteristics during safety rope fastening. The trajectory of the safety rope can be reconstructed and monitored through inertial measurement units and a time series approach. The results of this study will contribute to the reconstruction and monitoring of safety rope attachment trajectories for scaffolding workers working at heights in order to prevent falls at construction sites.
Opportunities and Challenges of Generative AI in Construction Industry: Focusing on Adoption of Text-Based Models
Authors: Ghimire Prashnna , Kim Kyungki , Acharya Manoj
Published: January 2024

In the last decade, despite rapid advancements in artificial intelligence (AI) transforming many industry practices, construction largely lags in adoption. Recently, the emergence and rapid adoption of advanced large language models (LLMs) like OpenAI’s GPT, Google’s PaLM, and Meta’s Llama have shown great potential and sparked considerable global interest. However, the current surge lacks a study investigating the opportunities and challenges of implementing Generative AI (GenAI) in the construction sector, creating a critical knowledge gap for researchers and practitioners. This underlines the necessity to explore the prospects and complexities of GenAI integration. Bridging this gap is fundamental to optimizing GenAI’s early stage adoption within the construction sector. Given GenAI’s unprecedented capabilities to generate human-like content based on learning from existing content, we reflect on two guiding questions: What will the future bring for GenAI in the construction industry? What are the potential opportunities and challenges in implementing GenAI in the construction industry? This study delves into reflected perception in literature, analyzes the industry perception using programming-based word cloud and frequency analysis, and integrates authors’ opinions to answer these questions. This paper recommends a conceptual GenAI implementation framework, provides practical recommendations, summarizes future research questions, and builds foundational literature to foster subsequent research expansion in GenAI within the construction and its allied architecture and engineering domains.
Performance Evaluation of Thermal Insulation Rubberized Mortar Modified by Fly Ash and Glass Fiber
Authors: Pan Zezhou , Liu Feng , Li Huawei , Li Xiaohui , Wang Daochu , Ling Zao , Zhu Huanyu , Zhu Yuhao
Published: January 2024

The utilization of waste rubber as a viable option for manufacturing building materials holds great significance for the sustainable development of the construction industry. This study explores the addition of two additives, fly ash (FA) and glass fiber (GF), to rubberized mortar in order to improve its performance. The impact of different waste rubber powder (RP) replacement rates and modified additive dosages on the performance of rubberized mortar, including fluidity, mechanical properties, drying shrinkage, impact resistance, and thermal insulation properties, was investigated. Furthermore, the analytic hierarchy process (AHP) was adopted to study the priorities of the rubberized mortar modified by FA and GF. The results indicate that the addition of RP leads to a decrease in mortar fluidity, mechanical properties, and drying shrinkage. However, it can enhance its impact resistance and thermal insulation properties. The additives, FA and GF, have a significant influence on the properties of rubberized mortar. By means of AHP method analysis, this study concludes that the optimal comprehensive properties of FA- and GF-modified rubberized mortar can be achieved by replacing 10% of sand with RP and using 10% FA and 0.4% GF. This study presents a configuration method for modified thermal insulation rubberized mortar, and it may lead to FA and GF being considered potential candidates for developing environmentally friendly building materials.
Determination of the Sound Absorption Area Inside an Elementary Classroom Using Three Acoustical Methods: Computer Modeling, 1/10-Scale Model Experiment, and Field Acoustic Measurement
Authors: Lee Seung-Min , Haan Chan-Hoon
Published: January 2024

Acoustic standards for classrooms around the world are still being studied, but the placement of sound-absorbing materials to meet these standards is still unclear. The present study examined an appropriate location for applying sound-absorbing materials inside an elementary classroom to ensure speech intelligibility while meeting the RT criterion using three scientific experimental methods, namely, computer modeling, a 1/10-scale model, and field acoustic measurement. A sound-absorbing material was applied to the rear wall or ceiling, and the ceiling was further divided into front, center, and rear sections. The acoustic performance was predicted using a 3D computer model of a standardized classroom based on the location of the sound-absorbing material. Subsequently, a 1/10-scale model following the law of similarity was used to compare the acoustic performances based on the location of the sound-absorbing material. Finally, field measurements were performed in an actual classroom to verify the acoustic performance based on the location of the sound-absorbing material. The findings revealed that the sound-absorbing material was most effective when applied to the rear wall, followed by application at the center, front, and rear of the ceiling.
Influence Law of Axis Deflection on the Mechanical Properties of Steel Stranded Short Slings in Arch Bridges
Authors: Deng Nianchun , Liang Hongjie , Zhu Guochao , Xu Jie , Tang Zhiyu
Published: January 2024

Most cable arch bridge damage accidents are caused by bridge collapse due to fracture of the short sling of the arch bridge. The service life of the short sling is much lower than the design life, mainly resulting from the action of vehicles and temperature, and the arch rib and the bridge floor will have relative displacement along the bridge direction, which leads to the emergence of bending stress due to the different axes at both ends of the short sling, forming local stress concentration. The stress concentration is coupled with corrosion to accelerate the damage to the sling. To study the influence of shaft deflection on the mechanical properties of short slings of steel strands in arch bridges, this study analyzes the distribution law of the shaft deflection angle of arch bridge slings under the action of vehicle and temperature loads for a medium-bearing arch bridge with a main span of 560 m. The results show that under different vehicle and temperature loads, the axial deflection angle of the short sling is the largest, and the closer it is to the center of the span, the smaller the axial deflection angle. The static and fatigue properties of 1, 3, 7, 9, 12, 19, and 27 strands of whole bunch extruded strand slings were simulated and analyzed under a 0.45σb force when the axial deflection angle of the strand slings was 0 mrad, 10 mrad, 20 mrad, and 30 mrad. The results show that the ultimate tensile properties, breaking strength, and fatigue life of the strand slings decreased to a certain extent with increasing shaft deflection angle. The accuracy of the finite element models is verified by the ultimate tensile test and the fatigue test. This study explores the bending deflection results of the short slings of arch bridges due to the different axes of the upper and lower anchorages and provides the necessary theoretical support for the design and fatigue life estimation of the short slings of arch bridges.
Strength Reduction Due to Acid Attack in Cement Mortar Containing Waste Eggshell and Glass: A Machine Learning-Based Modeling Study
Authors: Zhu Fei , Wu Xiangping , Lu Yijun , Huang Jiandong
Published: January 2024

The present study utilized machine learning (ML) techniques to investigate the effects of eggshell powder (ESP) and recycled glass powder (RGP) on cement composites subjected to an acidic setting. A dataset acquired from the published literature was employed to develop machine learning-based predictive models for the cement mortar’s compressive strength (CS) decrease. Artificial neural network (ANN), K-nearest neighbor (KNN), and linear regression (LR) were chosen for modeling. Also, RreliefF analysis was performed to study the relevance of variables. A total of 234 data points were utilized to train/test ML algorithms. Cement, sand, water, silica fume, superplasticizer, glass powder, eggshell powder, and 90 days of CS were considered as input variables. The outcomes of the research showed that the employed models could be applied to evaluate the reduction percentage of CS in cement composites, including ESP and RGP, after being exposed to acid. Based on the R2 values (0.87 for the ANN, 0.81 for the KNN, and 0.78 for LR), as well as the assessment of variation between test values and anticipated outcomes and errors (1.32% for ANN, 1.57% for KNN, and 1.69% for LR), it was determined that the accuracy of the ANN model was superior to the KNN and LR. The sieve diagram exhibited a correlation amongst the model predicted and target results. The outcomes of the RreliefF analysis suggested that ESP and RGP significantly influenced the CS loss of samples with RreliefF scores of 0.26 and 0.21, respectively. Based on the outcomes of the research, the ANN approach was determined suitable for predicting the CS loss of mortar subjected to acidic environments, thereby eliminating lab testing trails.
Recycling of Aluminosilicate-Based Solid Wastes through Alkali-Activation: Preparation, Characterization, and Challenges
Authors: Feng Lichao , Yi Shengjie , Zhao Shuyuan , Zhong Qiucheng , Ren Feirong , Liu Chen , Zhang Yu , Wang Wenshou , Xie Ning , Li Zhenming , Cui Na
Published: January 2024

Recycling aluminosilicate-based solid wastes is imperative to realize the sustainable development of constructions. By using alkali activation technology, aluminosilicate-based solid wastes, such as furnace slag, fly ash, red mud, and most of the bio-ashes, can be turned into alternative binder materials to Portland cement to reduce the carbon footprint of the construction and maintenance activities of concrete structures. In this paper, the chemistry involved in the formation of alkali-activated materials (AAMs) and the influential factors of their properties are briefly reviewed. The commonly used methods, including X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TG), nuclear magnetic resonance spectroscopy (NMR), and X-ray pair distribution function technology, to characterize the microstructure of AAMs are introduced. Typical characterization results of AAMs are shown and the limitations of each method are discussed. The main challenges, such as shrinkage, creep, efflorescence, carbonation, alkali–silica reaction, and chloride ingress, to conquer for a wider application of AAMs are reviewed. It is shown that several performances of AAMs under certain circumstances seem to be less satisfactory than traditional portland cement systems. Existing strategies to improve these performances are reviewed, and recommendations for future studies are given.
Establishment of an Environmental Impact Factor Database for Building Materials to Support Building Life Cycle Assessments in China
Authors: Jang Hyeong-Jae , Wang Seong-Jo , Tae Sung-Ho , Zheng Peng-Fei
Published: January 2024

The construction industry increasingly poses significant threats on the environment, highlighting the importance of developing life cycle assessments (LCAs). Research on building LCA databases has been carried out in many countries. However, in China, the absence of public data for environmental impact assessments poses significant challenges for building life cycle assessments (LCA). Therefore, this study aims to facilitate the life cycle assessment of buildings in China by comparing and analyzing databases from South Korea and the European Union. The goal is to establish a unit-based environmental impact database for Chinese building materials. Three environmental impact factors of ten major building materials in these three databases were compared and a basis for the inter-application of the databases was established. Based on the combination of the analysis results, the supplementation of the environmental impact factor database of building materials in China was proposed. In addition, a case study using a quantity take-off (QTO) for an actual building in China was performed to review the plan’s applicability.
Impact of the Saudi Building Code on Residential Construction Costs
Authors: Allahaim Fahad Saud , El shenawy Ahmed M. , Alfalah Ghasan
Published: January 2024

The government of Saudi has implemented the Saudi Building Code (SBC) for residential buildings to set standards for their design, construction, and maintenance. However, this may result in unexpected costs that are passed on to the citizens and thus have a certain economic impact. Therefore, this study examined the additional costs imposed on citizens and the economic impact of implementing the SBC on residential buildings. This study surveyed building developers, architects, and citizens to gather data on the costs associated with adhering to the code such as material and labor costs. This study found that the additional costs imposed on citizens and the economic impact of implementing the SBC in residential buildings were relatively small. The potential long-term benefits of the SBC such as energy efficiency savings and reduced environmental impact outweigh the short-term costs. The case that applied the SBC had operating costs that were almost 44% lower. Energy efficiency was increased by the SBC’s contribution to reducing heat transfer through building components and external elements. In order to minimize heat absorption and electricity usage, thermal insulation, double and heat-reflecting glass, and light exterior colors are all recommended. The findings of this research provide valuable insights for policymakers and stakeholders in the construction industry because they consider the implementation and enforcement of building codes in the Kingdom of Saudi Arabia.
Experimental and Numerical Study on the Thermal Response of the Lightweight Aggregate Concrete Panels Integrated with MPCM
Authors: Zhu Lin , Wang Qiaoyu , Sang Guochen , Cao Zhengzheng , Xue Yi
Published: January 2024

This paper determines the best design parameters and uses conditions of lightweight aggregate concrete panels containing microencapsulated phase change materials (MPCM-LWAC panels). The main work of this paper includes the followings: (1) The fundamental properties (dry density, thermal conductivity, and specific heat capacity) of MPCM-LWAC were researched to reveal the effect of MPCM dosage on these properties. (2) A model test was carried out to quantify the effect of MPCM dosage on the thermal response of the MPCM-LWAC panel exposed to realistic climate conditions. (3) The numerical simulation was conducted to investigate the effect of MPCM dosage, panel thickness, and outdoor temperature conditions on the thermal response of the MPCM-LWAC panel, which helps to determine its optimum design parameters and use condition. The results showed that the incorporation of MPCM results in lower dry density and thermal conductivity of MPCM-LWAC but higher specific heat capacity. The more MPCM dosage in the MPCM-LWAC panel with a thickness of 35 mm, the lower the energy demand to keep a comfortable interior temperature. Most notably, when the panel thickness exceeds 105 mm, the MPCM-LWAC panel with 5% MPCM only delays the peak temperature. Moreover, the optimal use condition for MPCM-LWAC panels is an average outdoor temperature of 25 °C, which makes the energy demand attain a minimum.
Methods for Selecting Design Alternatives through Integrated Analysis of Energy Performance of Buildings and the Physiological Responses of Occupants
Authors: Kim Sanghee , Ryu Jihye , Lee Yujeong , Park Hyejin , Lee Kweonhyoung
Published: January 2024

We propose a technique that allows designers to develop energy-efficient buildings focused on occupants from the early design stage. The technique integrates the physiological responses of occupants and the energy performance of buildings. Among the architectural design elements, we considered the aspect ratio, ceiling height, and window-to-wall ratio as design variables and created 30 design alternatives for a single-occupancy room in a postpartum care center. These design alternatives were recreated in virtual reality, allowing 33 female participants to immerse themselves in the designed rooms. During the experiment, we collected electroencephalography (EEG) data from the participants. Furthermore, we used DesignBuilder to simulate 30 design alternatives and calculated the primary energy consumption per unit area for each alternative. By integrating the EEG data and energy performance analysis, we identified the design alternative among the 30 options that positively influenced the physiological responses of occupants while also being energy efficient. The selected alternative was designed with an aspect ratio of 1:1.6, a ceiling height of 2.3 m, and a window-to-wall ratio of 60%. This research represents a creative exploration that demonstrates how studies combining human physiological responses and architecture can evolve through integration with other subjects. Our findings provide a robust framework to explore the relationship between physiological responses and energy optimization for detailed architectural design elements.
Conservation of Defensive Military Structures Built with Rammed Earth
Authors: Rocha Miguel , Faria Paulina , Gago António Sousa
Published: January 2024

Earth is a complex material with mechanical and physical behaviors that differ from modern building materials. The conservation of rammed-earth (RE) constructions presents specific difficulties that are challenging to overcome. A lack of knowledge about RE due to its abandonment for decades and interventions adopting materials and repair methodologies designed for conventional constructions have led to inadequate interventions. In the case of historic defensive constructions, the doubts and technical difficulties are even greater due to the nature of so-called military RE (with physical and mechanical characteristics which differ significantly from those of civil, more common RE) and, not least, due to the historical and cultural heritage value of these constructions. Some important interventions have been carried out recently, while others are underway or in the planning stage, and there is a constant lack of information and technical data regarding the best ways to intervene. To fill this gap, the state of conservation of defensive RE structures and the results of interventions carried out throughout history in the southwest of the Iberian Peninsula are being assessed. This article sets out a framework for the subject, identifies material and construction techniques and recognises the main causes of RE constructions’ deterioration and decay. With special focus on the most frequent damages detected in historic military defensive structures built with RE, it analyses and discusses the most common techniques that have been used for the repair and conservation of these particular structures.
The Magee 3 Equation Predicts Favorable Pathologic Response to Neoadjuvant Endocrine Therapy in Breast Cancer Patients
Authors: Paiva Carlos Eduardo , Zonta Maria Paola Montesso , Granero Rafaela Carvalho , Guimarães Vitor Souza , Pimenta Layla Melo , Teixeira Gustavo Ramos , Paiva Bianca Sakamoto Ribeiro
Published: January 2024

Background: Breast cancer (BC) remains a significant health care challenge, and treatment approaches continue to evolve. Among these, neoadjuvant endocrine therapy (NET) has gained prominence, particularly for postmenopausal, hormone-receptor positive, HER2-negative (HR+/HER2−) BC patients. Despite this, a significant gap exists in identifying patients who stand to benefit from NET. The objective of this study was to assess whether Magee equations (MEs) could serve as predictors of response to NET. Methods: This retrospective study included adult patients with invasive BC who underwent NET followed by curative surgery. Assessment of sociodemographic, clinical, and tumor-related variables was conducted. The ME1, ME2, ME3, and ME mean were analyzed to explore their predictive role for NET response. Receiver operating characteristic (ROC) curves were employed, along with the determination of optimal cutoff points. Logistic regression models were utilized to identify the most significant predictors of pathological response. Results: Among the 75 female participants, the mean age was 69.4 years, with the majority being postmenopausal (n = 72, 96%) and having an ECOG-PS of 0/1 (n = 63, 84%). Most patients were classified as luminal A (n = 41, 54.7%). ME3 emerged as a promising predictor, boasting an AUC of 0.734, with sensitivity of 90.62% and specificity of 57.50% when the threshold was ≤ 19.97. In univariate analysis, clinical staging (p = 0.002), molecular subtype (p = 0.001), and ME3 (continuous = 0.001, original 3-tier: p = 0.013, new 2-tier: <0.001) categories exhibited significant associations with pathological response. In the multivariate model, clinical staging and new 2-tier ME3 (<20 vs. ≥20) were included as significant variables. Conclusions: Patients with ME3 < 20 have a higher likelihood of presenting a pathological response, offering a cost-effective alternative tool to Oncotype DX. Larger future studies with a prospective design are awaited to confirm our findings.
Incidence of Cutaneous Immune-Related Adverse Events and Outcomes in Immune Checkpoint Inhibitor-Containing Regimens: A Systematic Review and Meta-Analysis
Authors: Curkovic Nina B. , Bai Kun , Ye Fei , Johnson Douglas B.
Published: January 2024

Immune checkpoint inhibitors (ICIs) are used to treat many cancers, and cutaneous immune-related adverse events (cirAEs) are among the most frequently encountered toxic effects. Understanding the incidence and prognostic associations of cirAEs is of importance as their uses in different settings, combinations, and tumor types expand. To evaluate the incidence of cirAEs and their association with outcome measures across a variety of ICI regimens and cancers, we performed a systematic review and meta-analysis of published trials of anti–programmed death-1/ligand-1 (PD-1/PD-L1) and anti–cytotoxic T lymphocyte antigen-4 (CTLA-4) ICIs, both alone and in combination with chemotherapy, antiangiogenic agents, or other ICIs in patients with melanoma, renal cell carcinoma, non-small cell lung cancer, and urothelial carcinoma. Key findings of our study include variable cirAE incidence among tumors and ICI regimens, positive association with increased cirAE incidence and response rate, as well as significant association between increased vitiligo incidence and overall survival. Across 174 studies, rash, pruritis, and vitiligo were the most reported cirAEs, with incidences of 16.7%, 18.0%, and 6.6%, respectively. Higher incidence of cirAEs was associated with ICI combination regimens and with CTLA-4-containing regimens, particularly with higher doses of ipilimumab, as compared to PD-1/L1 monotherapies. Outcome measures including response rate and progression-free survival were positively correlated with incidence of cirAEs. The response rate and incidence of pruritis, vitiligo, and rash were associated with expected rises in incidence of 0.17% (p = 0.0238), 0.40% (p = 0.0010), and 0.18% (p = 0.0413), respectively. Overall survival was positively correlated with the incidence of pruritis, vitiligo, and rash; this association was significant for vitiligo (p = 0.0483). Our analysis provides benchmark incidence rates for cirAEs and links cirAEs with favorable treatment outcomes at a study level across diverse solid tumors and multiple ICI regimens.
Ocular Surface Side Effects of Novel Anticancer Drugs
Authors: Vitiello Livio , Lixi Filippo , Coco Giulia , Giannaccare Giuseppe
Published: January 2024

Surgery, anticancer drugs (chemotherapy, hormonal medicines, and targeted treatments), and/or radiation are common treatment strategies for neoplastic diseases. Anticancer drugs eliminate malignant cells through the inhibition of specific pathways that contribute to the formation and development of cancer. Given the ability of such pharmacological medications to combat cancerous cells, their role in the management of neoplastic diseases has become essential. However, these drugs may also lead to undesirable systemic and ocular adverse effects due to cyto/neuro-toxicity and inflammatory reactions. Ocular surface side effects are recognized to significantly impact patient’s quality of life and quality of vision. Blepharoconjunctivitis is known to be a common side effect caused by oxaliplatin, cyclophosphamide, cytarabine, and docetaxel, while anastrozole, methotrexate, and 5-fluorouracil can all determine dry eye disease. However, the potential processes involved in the development of these alterations are yet not fully understood, especially for novel drugs currently available for cancer treatment. This review aims at analyzing the potential ocular surface and adnexal side effects of novel anticancer medications, trying to provide a better understanding of the underlying pharmacological processes and useful insights on the choice of proper management.
Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors
Authors: Foote Robert L. , Harmsen W. Scott , Amundson Adam C. , Carr Alan B. , Gamez Mauricio E. , Garces Yolanda I. , Lester Scott C. , Ma Daniel J. , McGee Lisa A. , Moore Eric J. , Neben Wittich Michelle A. , Patel Samir H. , Routman David M. , Rwigema Jean-Claude M. , Van Abel Kathryn M. , Yin Linda X. , Muller Olivia M. , Shiraishi Satomi
Published: January 2024

Background: Approximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient’s quality of life and function. The purpose of this study was to explore associations between RT dose to a defined oral cavity organ-at-risk (OAR) avoidance structure, provider- and patient-reported outcomes (PROs), opioid use, and hospitalization. Methods: This was a retrospective analysis of prospectively obtained outcomes using multivariable modeling. The study included 196 patients treated with RT involving the oral cavity for a head and neck tumor. A defined oral cavity OAR avoidance structure was used in all patients for RT treatment planning. Validated PROs were collected prospectively. Opioid use and hospitalization were abstracted electronically from medical records. Results: Multivariable modeling revealed the mean dose to the oral cavity OAR was significantly associated with opioid use (p = 0.0082) and hospitalization (p = 0.0356) during and within 30 days of completing RT. Conclusions: The findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment.
Exploring the Spectrum of VEGF Inhibitors’ Toxicities from Systemic to Intra-Vitreal Usage in Medical Practice
Authors: Santorsola Mariachiara , Capuozzo Maurizio , Nasti Guglielmo , Sabbatino Francesco , Di Mauro Annabella , Di Mauro Giordana , Vanni Gianluca , Maiolino Piera , Correra Marco , Granata Vincenza , Gualillo Oreste , Berretta Massimiliano , Ottaiano Alessandro
Published: January 2024

The use of Vascular Endothelial Growth Factor inhibitors (VEGFi) has become prevalent in the field of medicine, given the high incidence of various pathological conditions necessitating VEGF inhibition within the general population. These conditions encompass a range of advanced neoplasms, such as colorectal cancer, non-small cell lung cancer, renal cancer, ovarian cancer, and others, along with ocular diseases. The utilization of VEGFi is not without potential risks and adverse effects, requiring healthcare providers to be well-prepared for identification and management. VEGFi can be broadly categorized into two groups: antibodies or chimeric proteins that specifically target VEGF (bevacizumab, ramucirumab, aflibercept, ranibizumab, and brolucizumab) and non-selective and selective small molecules (sunitinib, sorafenib, cabozantinib, lenvatinib, regorafenib, etc.) designed to impede intracellular signaling of the VEGF receptor (RTKi, receptor tyrosine kinase inhibitors). The presentation and mechanisms of adverse effects resulting from VEGFi depend primarily on this distinction and the route of drug administration (systemic or intra-vitreal). This review provides a thorough examination of the causes, recognition, management, and preventive strategies for VEGFi toxicities with the goal of offering support to oncologists in both clinical practice and the design of clinical trials.
Non-Curative Treatment Choices in Colorectal Cancer: Predictors and Between-Hospital Variations in Denmark: A Population-Based Register Study
Authors: Rattenborg Søren , Frøstrup Hansen Torben , Möller Sören , Frostberg Erik , Rahr Hans Bjarke
Published: January 2024

Background: Variations in treatment choices have been reported in colorectal cancer (CRC). In the context of national recommendations, we aimed to elucidate predictors and between-hospital variations in refraining from curatively intended surgery and adjuvant chemotherapy in potentially curable colorectal cancer. Methods: A total of 34,116 patients diagnosed with CRC from 2009 to 2018 were included for analyses on non-curative treatment in this register-based study. Subsequently 8006 patients were included in analyses on adjuvant treatment. Possible predictors included patient-, disease-, socioeconomic- and perioperative-related factors. Logistic regressions were utilized to examine the predictors of a non-curative aim of treatment and no adjuvant chemotherapy. Results: The predictors of non-curative treatment were high age, poor performance, distant metastases and being underweight. Predictors for no adjuvant treatment were high age, poor performance, kidney disease, postoperative complications and living alone. For both outcomes we found between-hospital variations to be present. Conclusions: Non-curative overall treatment and refraining from adjuvant chemotherapy were associated with well-known risk factors, but the former was also associated with being underweight and the latter was also associated with living alone. Marked between-hospital variations were found and should be examined further.
Practice Changes in Checkpoint Inhibitor-Induced Immune-Related Adverse Event Management at a Tertiary Care Center
Authors: Shatila Malek , Eshaghi Farzin , Thomas Austin R. , Kuang Andrew G. , Shah Jay S. , Zhao Brandon , Naz Sidra , Sun Mianen , Fayle Sarah , Jin Jeff , Abudayyeh Ala , Sheshadri Ajay , Palaskas Nicolas L. , Franco-Vega Maria C. , Gaeta Maria S. , Thomas Anusha S. , Zhang Hao Chi , Wang Yinghong
Published: January 2024

Understanding of immune-related adverse events (irAEs) has evolved rapidly, and management guidelines are continually updated. We explored temporal changes in checkpoint inhibitor-induced irAE management at a tertiary cancer care center to identify areas for improvement. We conducted a single-center retrospective study of patients who developed a gastrointestinal, pulmonary, renal, or cardiac irAE between July and 1 October in 2019 or 2021. We collected patient demographic and clinical information up to 1 year after toxicity. Endoscopic evaluation and specialty follow-up after discharge for patients with gastrointestinal irAEs declined between the 2019 and 2021 periods. Symptom duration and steroid taper attempts also declined. For pulmonary irAEs, rates of specialty consultation, hospital admission and readmission, and mortality improved in 2021 compared with 2019. Follow-up rates after hospital discharge were consistently low (<50%) in both periods. For cardiac irAEs, consultation with a cardiologist was frequent and prompt in both periods. Outpatient treatment and earlier specialty consultation improved outcomes with gastrointestinal irAEs. Our study exploring irAE practice changes over time identified areas to improve management; specifically, timely specialty consultation was associated with better outcomes for gastrointestinal irAEs. These findings can help improve the quality of management algorithms at our institution and may inform policies in other institutions.
PIK Your Poison: The Effects of Combining PI3K and CDK Inhibitors against Metastatic Cutaneous Squamous Cell Carcinoma In Vitro
Authors: Perry Jay R. , Genenger Benjamin , Thind Amarinder Singh , Ashford Bruce , Ranson Marie
Published: January 2024

Cutaneous squamous cell carcinoma (cSCC) is a very common skin malignancy with poor prognosis for patients with locally advanced or metastatic cSCC (mcSCC). PI3K/AKT/mTOR and cell cycle signalling pathways are often dysregulated in mcSCC. A combination drug approach has been theorised to overcome the underwhelming clinical performance of targeted inhibitors as single agents. This study investigates the potential of targeted inhibition of the p110α−subunit of PI3K with PIK-75 or BGT226 (P13Ki), and of CDK1/2/5/9 with dinaciclib (CDKi) as single agents and in combination. The patient−derived mcSCC cell lines, UW-CSCC1 and UW-CSCC2, were used to assess cell viability, migration, cell signalling, cell cycle distribution, and apoptosis. PIK-75, BGT226, and dinaciclib exhibited strong cytotoxic potency as single agents. Notably, the non-malignant HaCaT cell line was unaffected. In 2D cultures, PIK-75 synergistically enhanced the cytotoxic effects of dinaciclib in UW-CSCC2, but not UW-CSCC1. Interestingly, this pattern was reversed in 3D spheroid models. Despite the combination of PIK-75 and dinaciclib resulting in an increase in cell cycle arrest and apoptosis, and reduced cell motility, these differences were largely negligible compared to their single-agent counterpart. The differential responses between the cell lines correlated with driver gene mutation profiles. These findings suggest that personalised medicine approaches targeting PI3K and CDK pathways in combination may yield some benefit for mcSCC, and that more complex 3D models should be considered for drug responsiveness studies in this disease.
Unraveling FeOx Nanoparticles Confined on Fibrous Mesoporous Silica Catalyst Construction and CO Catalytic Oxidation Performance
Authors: Li Guobo , Feng Weiwei , Luo Yiwei , Yan Jie , Cai Yining , Wang Yiling , Zhang Shule , Liu Wenming , Peng Honggen
Published: January 2024

Catalytic oxidation is used to control carbon monoxide (CO) emissions from industrial exhaust. In this study, a mesoporous silica material, KCC-1, was synthesized and used as a carrier with a high specific surface area to confine active component FeOx nanoparticles (NPs), and the CO catalytic oxidation performance of x%Fe@KCC-1 catalysts (x represents the mass loading of Fe) was studied. The experimental results showed that due to its large specific surface area and abundant mesopores, the FeOx NPs were highly dispersed on the surface of the KCC-1 carrier. The particle size of FeOx was very small, resulting in strong interactions between FeOx NPs and KCC-1, which enhanced the catalytic oxidation reaction on the catalyst. The FeOx loading improved the CO adsorption capability of the catalyst, which facilitated the catalytic oxidation of CO, with the 7%Fe@KCC-1 catalyst achieving 100% CO conversion at 160 °C. The CO catalytic removal mechanism was investigated by a combination of in-situ DRIFTS and DFT calculations. This study advances scientific understanding of the application potential of nano-catalysts in important oxidation reactions and provides valuable insights into the development of efficient CO oxidation catalysts.
Hydrochloric Acid Catalyzed Hydrothermal Treatment to Recover Phosphorus from Municipal Sludge
Authors: Liu Kai , Xue Yang , Zhai Yawei , Zhou Lisong , Kang Jian
Published: January 2024

Resource utilization of sludge is critical because traditional sludge treatment methods cause a large amount of nutrient loss. This study investigated the impact of hydrochloric acid quantity, reaction temperature, and time on phosphorus release and migration from municipal sludge during hydrothermal treatment and designed a sludge disposal method for the recovery and utilization of phosphorus resources. We know that hydrochloric acid destroys the complexation of calcium and phosphorus precipitates, leading to the selective transfer of phosphorus to the liquid phase, and that the addition of 1–5% hydrochloric acid corresponds to a phosphorus extraction rate in the range of 0.3–98%. When hydrochloric acid is added, a change in temperature and reaction time has a negligible effect on phosphorus. Phosphorus can be recovered using the liquid product obtained under the optimal hydrothermal reaction conditions (adding 5% HCl at 205 °C for 30 min). After adjusting the pH value and adding the magnesium source, struvite (MgNH4PO4·6H2O) can be precipitated quickly and with high purity. At a cost of USD 27.8/ton of sludge, this method can recover 94% of the phosphorus in the sludge, and the bioavailable phosphorus ratio of the product is 93%, therefore, providing an important alternative to existing phosphorus recovery technologies.
Synergistic Effect of Structure and Morphology of ZSM-5 Catalysts on the Transformation of Methanol to Propylene
Authors: Zhang Wei , Wang Kangzhou , Gao Xinhua , Yong Xiaojing , Gu Yanlong
Published: January 2024

Here, the efficient synthesis of propylene from methanol was achieved using a series of HZSM-5 catalysts. The effect of the structure and morphology of ZSM-5 on the conversion of methanol to propylene was studied. The structure and physicochemical properties of the synthesized catalysts were analyzed by multiple characterization techniques. The characterization results revealed that the alumina content rationally modified the acid properties of ZSM-5. When using a ZSM-5 catalyst with a hexagonal single crystal and a Si/Al ratio of 177, the selectivity of propylene reached 39.7% at 480 °C. Furthermore, the formation of methane was reduced. This provides a clue for catalyst design to enable the selective transformation of methanol into propylene.
Real-Time Dynamics of Water Transport in the Roots of Intact Maize Plants in Response to Water Stress: The Role of Aquaporins and the Contribution of Different Water Transport Pathways
Authors: Suslov Maksim , Daminova Amina , Egorov Juluskhan
Published: January 2024

Using an original methodological and technical approach, we studied the real-time dynamics of radial water transfer in roots and transpiration rate in intact maize plants in response to water stress. It was shown that the response of maize plants to water stress, induced by 10% PEG 6000, was accompanied by changes in the intensity and redistribution of water transfer along different pathways of radial water transport in the roots. It was shown that during the first minutes of water stress impact, the intensity of transcellular and symplastic water transport in the roots decreased with a parallel short-term increase in the transpiration rate in leaves and, presumably, in apoplastic transport in roots. Further, after a decrease in transpiration rate, the intensity of transcellular and symplastic water transport was restored to approximately the initial values and was accompanied by parallel upregulation of some PIP aquaporin genes in roots and leaves, changes in aquaporin localization in root tissues, and changes in xylem sap pH. Under water stress conditions, cell-to-cell water transport in roots becomes dominant, and aquaporins contribute to the simultaneous regulation of water transport in roots and shoots under water stress.
PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation
Authors: Fütterer Agnes , Rodriguez-Acebes Sara , Méndez Juan , Gutiérrez Julio , Martínez-A Carlos
Published: January 2024

The regulated formation and resolution of R-loops is a natural process in physiological gene expression. Defects in R-loop metabolism can lead to DNA replication stress, which is associated with a variety of diseases and, ultimately, with cancer. The proteins PARP1, DIDO3, and DHX9 are important players in R-loop regulation. We previously described the interaction between DIDO3 and DHX9. Here, we show that, in mouse embryonic fibroblasts, the three proteins are physically linked and dependent on PARP1 activity. The C-terminal truncation of DIDO3 leads to the impairment of this interaction; concomitantly, the cells show increased replication stress and senescence. DIDO3 truncation also renders the cells partially resistant to in vitro oncogenic transformation, an effect that can be reversed by immortalization. We propose that PARP1, DIDO3, and DHX9 proteins form a ternary complex that regulates R-loop metabolism, preventing DNA replication stress and subsequent senescence.
Unveiling the Molecular Signature of High-Temperature Cooking: Gas Chromatography-Mass Spectrometry Profiling of Sucrose and Histidine Reactions and Its Derivatives Induce Necrotic Death on THP1 Immune Cells
Authors: Periasamy Vaiyapuri Subbarayan , Athinarayanan Jegan , Alshatwi Ali A.
Published: January 2024

High-temperature cooking processes like frying, baking, smoking, or drying can induce chemical transformations in conventional food ingredients, causing deteriorative modifications. These reactions, including hydrolytic, oxidative, and thermal changes, are common and can alter the food’s chemical composition. This study transformed a combination of sucrose and histidine (Su-Hi) through charring or pyrolysis. The GC-MS profiling study showed that when sucrose and histidine (Su-Hi) were exposed to high temperatures (≈240 °C), they produced carbonyl and aromatic compounds including beta-D-Glucopyranose, 1,6-anhydro (10.11%), 2-Butanone, 4,4-dimethoxy- (12.89%), 2(1H)-Quinolinone-hydrazine (5.73%), Benzenamine (6.35%), 2,5-Pyrrolidinedione, 1-[(3,4-dimethylbenzoyl)oxy]- (5.82%), Benzene-(1-ethyl-1-propenyl) (5.62%), and 4-Pyridinamine-2,6-dimethyl (5.52%). The compounds mentioned can permeate the cell membrane and contribute to the development of cell death by necrosis in human immune cells. The evidence suggests that a specific set of pyrolytic compounds may pose a risk to immune cells. This investigation reveals the complex relationship between high-temperature cooking-induced transformations, compound permeation inside the cells, and downstream cellular responses, emphasizing the significance of considering the broader health implications of food chemical contaminants.