bluuebunny/crossref_metadata_2025 huggingface dataset:
Overwintering of West Nile Virus in Southern California
Authors: Reisen William K. , Fang Ying , Lothrop Hugh D. , Martinez Vincent M. , Wilson Jennifer , O’Connor Paul , Carney Ryan , Cahoon-Young Barbara , Shafii Marzieh , Brault Aaron C.
Published: January 2015

West Nile virus (family Flaviviridae, genus Flavivirus, WNV) invaded southern California during 2003, successfully overwintered, amplified to epidemic levels, and then dispersed to every county in the state. Although surveillance programs successfully tracked and measured these events, mechanisms that allowed the efficient overwintering and subsequent amplification of WNV have not been elucidated. Our current research provided evidence for three mechanisms whereby WNV may have persisted in southern California during the winters of 2003–2004 and 2004–2005: 1) continued enzootic transmission, 2) vertical transmission by Culex mosquitoes, and 3) chronic infection in birds. WNV was detected in 140 dead birds comprising 32 species, including 60 dead American crows, thereby verifying transmission during the November–March winter period. Dead American crows provide evidence of recent transmission because this species always succumbs rapidly after infection. However, WNV RNA was not detected concurrently in 43,043 reproductively active female mosquitoes comprising 11 species and tested in 1,258 pools or antibody in sera from 190 sentinel chickens maintained in 19 flocks. Although efficient vertical transmission by WNV was demonstrated experimentally for Culex tarsalis Coquillett infected per os, 369 females collected diapausing in Kern County and tested in 32 pools were negative for WNV. Vertical transmission was detected in Culex pipiens quinquefasciatus Say adults reared from field-collected immatures collected from Kern County and Los Angeles during the summer transmission period. Chronic infection was detected by finding WNV RNA in 34 of 82 birds that were inoculated with WNV experimentally, held for >6 wk after infection, and then necropsied. Frequent detection of WNV RNA in kidney tissue in experimentally infected birds >6 wk postinfection may explain, in part, the repeated detection of WNV RNA in dead birds recovered during winter, especially in species such as mourning doves that typically do not die after experimental infection. In summary, our study provides limited evidence to support multiple modes of WNV persistence in southern California. Continued transmission and vertical transmission by Culex p. quinquefasciatus Say seem likely candidates for further study.
Mosquito Species (Diptera: Culicidae) and the Transmission of Ross River Virus in Brisbane, Australia
Authors: Hu Wenbiao , Tong Shilu , Mengersen Kerrie , Oldenburg Brian , Dale Pat
Published: January 2015

This study aimed to identify the major mosquito vectors of Ross River virus (family Togaviridae, genus Alphavirus, RRV) and to explore the threshold of mosquito abundance necessary for RRV transmission in Brisbane, Australia. Data on the monthly counts of RRV cases by statistical local areas from the Queensland Health and the monthly mosquito abundance in Brisbane between November 1998 and December 2001 from the Brisbane City Council were used to assess the pairwise relationship between mosquito abundance and the incidence of RRV disease over a range of time lags using cross-correlations. We used time series Poisson regression models to identify major mosquito species associated with incidence of RRV after adjusting for overdispersion, maximum temperature, autocorrelation, and seasonality. Our results show that Aedes vigilax (Skuse) (relative risk [RR] = 1.32; 95% CI = 1.01–1.74 per 100 mosquitoes per trap) and Culex annulirostris (Skuse) (RR = 1.14, 95% CI = 1.04–1.24 per 100 mosquitoes per trap) were most strongly associated with RRV transmission at a lag of 1 mo. Classification and regression tree (CART) analyses indicate that the occurrence of RRV was associated with an average monthly mosquito abundance of Aedes vigilax above 72 and Cx. annulirostris above 52. The validation analyses indicate that the crude agreement between predicted values and actual observations was 76% (sensitivity, 61%; specificity, 80%). The results may have applications as a decision support tool in planning disease control and risk-management programs.
Amblyomma triste (Acari: Ixodidae): New North American Collection Records, Including the First From the United States
Authors: Mertins James W. , Moorhouse Arnold S. , Alfred Jeffery T. , Hutcheson H. Joel
Published: January 2015

New distribution records for the Neotropical tick, Amblyomma triste Koch, are identified from 27 specimens in 18 separate collections. These collections originated from six now recognized geographical foci in two states in the United States (Cochise and Santa Cruz Counties, Arizona, and Brewster and Jeff Davis Counties, Texas) and from import cattle, Bos taurus L., presented for entry at the United States border and originating in three Mexican states (Coahuila, Durango, and Sonora). For at least 67 yr, A. triste has existed in some areas of the United States as a cryptic species, and specimens there have been confused with and identified as Gulf Coast ticks, Amblyomma maculatum Koch, even by noted tick specialists. Most of the records reported in this study were from reidentified, archived specimens of putative A. maculatum.
γ Ray Dosimetry and Mating Capacity Studies in the Laboratory on Aedes albopictus Males
Authors: Balestrino F. , Medici A. , Candini G. , Carrieri M. , Maccagnani B. , Calvitti M. , Maini S. , Bellini R.
Published: January 2015

In Italy, Aedes albopictus Skuse is currently recognized as the most dangerous mosquito, and as currently applied conventional control methods gave unsatisfactory results, we are developing alternative strategies such as the sterile insect technique. To find the optimal sterilizing dose, male pupae were exposed to different doses of γ rays in the range 20–80 Gy, generated by a Cesium-137 source. The effects of male pupal age at irradiation and γ ray dose on adult male emergence, sterility level, longevity, and mating capacity were evaluated, and dose-response curves of residual fertility were calculated. Radiation tests were also performed on female pupae to observe their reproductive capacity in case of accidental release. Results confirmed that the age at which the male pupa is irradiated is an important factor that affects the longevity of the adult, whereas the effect of age on the induced sterility level is less pronounced. When male pupae older than 30 h were irradiated, the longevity of the adults was not affected by doses up to 40 Gy. The 40-Gy dose appeared sufficient to induce high level of sterility (>99%) at any male pupal age for all the strains tested. The duration of coupling and the number of mated females per male appeared to be affected by the radiation received by male pupae only at doses higher than 40 Gy. The female pupae were more sensitive to radiation than male pupae, with strong reduction in fecundity and fertility at 20 Gy and complete suppression of oviposition at higher doses.
Temporal Dynamics of Malaria Transmission in Two Rural Areas of Burkina Faso With Two Ecological Differences
Authors: Edith Ilboudo-Sanogo , Alfred Tiono B. , N′falé Sagnon , Nadine Cuzin Ouattara , Issa Nébié , B. Sirima Sodiomon
Published: January 2015

To determine the relationship between malaria transmission intensity, clinical malaria, immune response, plasmodic index, and to furthermore characterize a malaria vaccine trial site for potential malaria vaccines candidate testing, a study was conducted in Tensobtenga and Balonguen, two villages in Burkina Faso characterized by different malaria transmission levels. The study villages are located in a Sudan savanna area. Malaria transmission is seasonal and peaks in September in these villages. Tensobtenga and Balonguen are comparables in all aspects, except the presence of an artificial lake and wetlands in Tensobtenga. The mosquitoes sampling sites were randomly selected, taking into consideration the number of potential breeding sites, and the number of households in each village. Three times a week during 12 mo mosquitoes were collected by the Center for Disease Control and Prevention light traps in sentinel sites. To assess the infectivity the mosquitoes double ELISAs tests were performed on thoraces of female Anopheles gambiae s.l. (Giles) and Anopheles funestus. A total of 54,392 female Anopheles, representing 92.71% of the total mosquitoes, were collected. The peaks of aggressiveness because of either An. gambiae s.l. or An. funestus were observed in September in each of the villages. However, these peaks were lower in Balonguen compared with Tensobtenga. Malaria cumulative aggressiveness and transmission intensity because of both species peaked in September in each of the two villages, with lower values in Balonguen in comparison to Tensobtenga. From February to May, malaria transmission intensity is negligible in Balonguen and <1 bite/person/mo is observed in Tensobtenga. These results have confirmed the marked seasonality of malaria transmission in the study area.
Laboratory Evaluation of the Efficacy of Fluorescent Biomarkers for Sugar-Feeding Sand Flies (Diptera: Psychodidae)
Authors: Mascari T. M. , Foil L. D.
Published: January 2015

The purpose of this study was to evaluate the use of four fluorescent dyes (rhodamine B, uranine O, auramine O, and erythrosin B) and two nonfluorescent dyes (carmoisine and indigotine) incorporated into sugar baits as biomarkers for phlebotomine sand flies. Each dye could be detected in sand flies fed baits with dye for 24 h when examined using bright field microscopy, although there was considerable variability in the marking produced; all sand flies that had ingested rhodamine B-treated sucrose solution were marked clearly. Sand flies that had ingested sucrose solution containing rhodamine B or uranine O at concentrations as low as 10 mg/L were consistently detected under fluorescence microscopy. None of the treatments in this study reduced the longevity of sand flies. All sand flies fed sucrose solution containing rhodamine B or uranine O were marked for at least 14 d, whereas only 20% of sand flies were marked 3 d after feeding on a carmoisine-treated solution. When rhodamine B and uranine O were combined in a single sucrose solution or when the dyes were fed sequentially to sand flies, both dyes could be detected in sand flies using fluorescence microscopy. We propose that rhodamine B- or uranine O-treated sucrose baits could be used in ecological studies or to identify portions of the adult sand fly population that could be targeted with insecticide-treated sugar baits.
Integrating landscape connectivity and habitat suitability to guide offensive and defensive invasive species management
Authors: Stewart‐Koster Ben , Olden Julian D. , Johnson Pieter T. J.
Published: January 2015

Preventing the arrival of invasive species is the most effective way of controlling their impact. Preventative strategies may be ‘offensive’ aimed at preventing the invader leaving colonised locations or ‘defensive’ aimed at preventing its arrival at uninvaded locations. The limited resources for invasive species control must be prioritized, particularly for numerous vulnerable locations or uncertainty about which sites are already invaded.

We developed an integrative modelling framework to prioritise locations for either strategy by incorporating connectivity and habitat suitability. We applied this framework to a data set comprising 5189 water bodies in Wisconsin and Michigan, U.S.A, for zebra mussels Dreissena polymorpha and Eurasian watermilfoil Myriophyllum spicatum. We developed the framework with a spatial graph based on recreational boater movement and habitat suitability models.

An historical graph comprised 3105 natural lakes connected in one of 18 components, whereas a total of 3944 water bodies (lakes and reservoirs) were connected in one of 13 separate components in a graph of the contemporary system. Habitat suitability models accounted for around half of the deviance in the distribution data for each species.

There was a distinct spatial pattern in the levels of risk and subsequent recommended allocation of management interventions across several levels of investment. Higher risk water bodies were generally found in the largest component of the spatial graph. At comparatively low levels of investment, where managers target 5% of all locales to control D. polymorpha, the results suggested that 71% and 27% of this effort should be committed to defensive and offensive strategies, respectively, in the largest component. For M. spicatum, 92% and 8% of this effort should be allocated in this component to defensive and offensive strategies, respectively. It is only with much greater investment that water bodies in other components should be targeted.

Synthesis and applications. Allocating limited resources to prevent the spread of invasive species is a challenge that transcends ecosystems and geography. We successfully identified a reduced number of locations to target for offensive and defensive intervention strategies for two species. This framework is readily applicable to other aquatic and terrestrial ecosystems vulnerable to invasive species.
Future Public Service Capacity: Employment of Young People into Australian Public Services during the GFC
Authors: Colley Linda , Price Robin
Published: January 2015

Public services face several workforce challenges, including impending retirements and austerity programs. Although employing more young people is a likely solution to balancing the demographic profile of public services, the literature and theory suggest that young people would have fared worse during the global financial crisis. This research tests propositions around the vulnerability of young people in selected Australian public services during the global financial crisis, in terms of quantity and quality of jobs obtained. Surprisingly, the findings suggest that many young people fared as well or sometimes better than other age cohorts during the global financial crisis in terms of both recruitment and access to ongoing jobs. There are several indications that perhaps public services provided a safe haven in a turbulent labour market.
DETERRENCE, CRIMINAL OPPORTUNITIES, AND POLICE
Authors: NAGIN DANIEL S. , SOLOW ROBERT M. , LUM CYNTHIA
Published: January 2015

In this article, we join three distinct literatures on crime control—the deterrence literature, the policing literature as it relates to crime control, and the environmental and opportunity perspectives literature. Based on empirical findings and theory from these literatures, we pose a mathematical model of the distribution of criminal opportunities and offender decision making on which of those opportunities to victimize. Criminal opportunities are characterized in terms of the risk of apprehension that attends their victimization. In developing this model, our primary focus is on how police might affect the distribution of criminal opportunities that are attractive to would‐be offenders. The theoretical model we pose, however, is generalizable to explain how changes in other relevant target characteristics, such as potential gain, could affect target attractiveness. We demonstrate that the model has important implications for the efficiency and effectiveness of police deployment strategies such as hot spots policing, random patrol, and problem‐oriented policing. The theoretical structure also makes clear why the clearance rate is a fundamentally flawed metric of police performance. Future research directions suggested by the theoretical model are discussed.
Qualitative Disclosure and Changes in Sell‐Side Financial Analysts' Information Environment
Authors: Bozanic Zahn , Thevenot Maya
Published: January 2015

We examine a routine and timely disclosure, earnings press releases, to determine the extent to which several novel qualitative elements of such disclosures are associated with changes in sell‐side financial analysts' information environment. Using a comprehensive set of GARCH‐based (generalized autoregressive conditional heteroscedasticity) proxies, we examine how disclosure readability's components, across‐document textual similarity, and within‐document lexical diversity alter analysts' information environment. We find that readability in the form of shorter sentences, textual similarity, and lexical diversity are strongly related to decreases in analysts' uncertainty. Further, shorter sentences and lexical diversity improve both public and private information precision, whereas similarity affects solely analysts' private information precision. While the GARCH‐based proxies allow us to alleviate concerns regarding potentially spurious inferences (Sheng and Thevenot 2012), we note as a caveat that such an estimation restricts our inferences to large, stable, and heavily followed firms. These findings should be of interest to analysts who may wish to explore the latent information contained within the qualitative elements of disclosure, regulators who direct the form and content of disclosure, and academics who study the use (and possible misuse) of various forms of information and its presentation.
Synthesis and Evaluation of a CBZ‐AAN‐Dox Prodrug and its in vitro Effects on SiHa Cervical Cancer Cells Under Hypoxic Conditions
Authors: Chen Hongyuan , Liu Xiao , Clayman Eric S. , Shao Fangyuan , Xiao Manshan , Tian Xuyan , Fu Wuyu , Zhang Caiyun , Ruan Bibo , Zhou Pengjun , Liu Zhong , Wang Yifei , Rui Wen
Published: January 2015

Although doxorubicin (Dox) is widely used in clinical treatment for solid tumors, it causes many side‐effects such as heart and kidney damage, bone marrow suppression, and drug resistance. Legumain is a lysosomal protease that is elevated and associated with an invasive and metastatic phenotype in a number of solid tumors. In this study, we designed and synthesized a Dox prodrug, N‐benzyloxycarbonyl‐Ala‐Ala‐Asn‐Doxorubicin (CBZ‐AAN‐Dox), with 94% purity. Single substrate kinetic assays demonstrated hLegumain‐specific enzymatic cleavage and activation of the prodrug in vitro, and this enzymatic cleavage of the prodrug substrate was more sensitive in acidic conditions, releasing more than 70% of Dox after 24 h. Treatment of tumor cells with our prodrug demonstrated a much higher IC50 value, significantly enhanced uptake of the prodrug, and considerably less cellular toxicity compared to Dox treatment alone. Our study presents a novel prodrug, CBZ‐AAN‐Dox, to potentially increase both the safety and efficacy of clinical treatment of tumors by exploiting the tumor's innate expression of legumain.
Triazole: A Promising Antitubercular Agent
Authors: Keri Rangappa S. , Patil Siddappa A. , Budagumpi Srinivasa , Nagaraja Bhari Mallanna
Published: January 2015

Tuberculosis is a contagious disease with comparatively high mortality worldwide. The statistics shows that around three million people throughout the world die annually from tuberculosis and there are around eight million new cases each year, of which developing countries showed major share. Therefore, the discovery and development of effective antituberculosis drugs with novel mechanism of action have become an insistent task for infectious diseases research programs. The literature reveals that, heterocyclic moieties have drawn attention of the chemists, pharmacologists, microbiologists, and other researchers owing to its indomitable biological potential as anti‐infective agents. Among heterocyclic compounds, triazole (1,2,3‐triazole/1,2,4‐triazole) nucleus is one of the most important and well‐known heterocycles, which is a common and integral feature of a variety of natural products and medicinal agents. Triazole core is considered as a privileged structure in medicinal chemistry and is widely used as ‘parental’ compounds to synthesize molecules with medical benefits, especially with infection‐related activities. In the present review, we have collated published reports on this versatile core to provide an insight so that its complete therapeutic potential can be utilized for the treatment of tuberculosis. This review also explores triazole as a potential targeted core moiety against tuberculosis and various research ongoing worldwide. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic triazole‐based antituberculosis drugs.
Lentivirus‐Mediated Silencing of Myosin VI Inhibits Proliferation and Cell Cycle Progression in Human Lung Cancer Cells
Authors: Yu Hui , Zhu Zhenghong , Chang Jianhua , Wang Jialei , Shen Xiaoyong
Published: January 2015

Myosin VI (MYO6) is a unique actin motor, which moves toward the pointed ends of actin filaments. In this study, we found that MYO6 is overexpressed in lung cancer tissues and associated with lung cancer progression, particularly lymph node metastasis. To investigate its functions in lung cancer cells, we generated recombinant lentivirus taking shRNA of MYO6. Using two lung cancer cell lines, A549 and 95D, we found that Lv‐shMYO6 could infect lung cancer cells with high efficiency and downregulate MYO6 on both mRNA and protein levels. After knockdown of MYO6, the proliferation rates of lung cancer cells were decreased significantly. The colony‐formation ability of MYO6‐silenced lung cancer cells was also impaired with reduced colony numbers and fewer cells per colony. Flow cytometry showed that cell cycle progression was stuck at the G0/G1 phase, especially at the sub‐G1 phase, which represents apoptotic cells. Moreover, knockdown of MYO6 downregulated the phosphorylation of ERK1/2. Further experiments using another shRNA of MYO6 confirmed the above results. These results suggest that MYO6 is crucial in maintaining cell cycle and cell growth of lung cancer cells. MYO6 may serve as a potential therapeutic target for lung cancer treatment.
Encore for the Enclave: The Changing Nature of the Industry Enclave with Illustrations from the Mining Industry in Chile
Authors: Phelps Nicholas A. , Atienza Miguel , Arias Martin
Published: January 2015

Conceptual innovation with respect to the enclave concept has been virtually absent compared with industry agglomerations. This is despite the fact that some varieties of agglomeration distinguished in the literature appear to come close to what previously were regarded as industrial enclaves and despite frequent allusions to the enclave nature of economic spaces produced by contemporary processes of globalization. Bringing the literature on agglomeration and enclaves into dialogue, we revisit the concept of the enclave—a concept that has been largely neglected since it enjoyed a popularity in connection with the study of particular (notably extractive) industries and particular (notably dependencia) theories of national economic development during the 1960s and 1970s. Much has changed since this time, which suggests that the concept of the enclave ought to be ripe for reevaluation. In this article we take an initial step in this direction, identifying analytical dimensions to the enclave and illustrating different manifestations of enclaves in the mining industry, drawing on the case of Chile. We conclude by advocating the renewed study of industry enclaves within contemporary economic geographic analysis.
MEDIA AND HUMAN CAPITAL DEVELOPMENT: CAN VIDEO GAME PLAYING MAKE YOU SMARTER?
Authors: Suziedelyte Agne
Published: January 2015

According to the literature, video game playing can improve such cognitive skills as problem solving, abstract reasoning, and spatial logic. I test this hypothesis using the data from the Child Development Supplement to the Panel Study of Income Dynamics. The endogeneity of video game playing is addressed by using panel data methods and controlling for an extensive list of child and family characteristics. To address the measurement error in video game playing, I instrument children's weekday time use with their weekend time use. After taking into account the endogeneity and measurement error, video game playing is found to positively affect children's problem solving ability. The effect of video game playing on problem solving ability is comparable to the effect of educational activities. (JEL I2, J13, J24)
Ambiguous Loss Experienced by Transnational Mexican Immigrant Families
Authors: Solheim Catherine , Zaid Samantha , Ballard Jaime
Published: January 2015

In this study, an ambiguous loss framework as described by Boss (1999, Ambiguous loss: Learning to live with unresolved grief, First Harvard University Press, Cambridge, MA) was used to examine and understand the family experiences of Mexican immigrant agricultural workers in Minnesota. Transcripts from interviews with 17 workers in Minnesota and 17 family members in Mexico were analyzed using qualitative methodology to identify experiences of ambiguous loss in the participants' narratives. Key dimensions of ambiguous loss identified in the transcripts include: psychological family, feelings of chronic/recurring loss, finding support, and meaning making. In the category of psychological family, participants in both Mexico and the United States mourned the physical absence of their family members and experienced ambiguity regarding family responsibilities, but worked to maintain their psychological roles within the family. In the category of chronic/recurring loss, participants in both countries experienced chronic worry from not knowing if family members were safe, ambiguity regarding when the immigrant would return, and chronic stressors that compounded these feelings of loss. Participants in both countries coped with both real and ambiguous losses by accessing family support and by using ambiguous communication to minimize worry. Participants in Mexico also accessed work and community‐based support. Participants in both countries made meaning of the ambiguous loss by identifying ways their lives were improved and goals were met as a result of the immigration for agricultural work in Minnesota.
Rationally engineered flavin‐dependent oxidase reveals steric control of dioxygen reduction
Authors: Zafred Domen , Steiner Barbara , Teufelberger Andrea R. , Hromic Altijana , Karplus P. Andrew , Schofield Christopher J. , Wallner Silvia , Macheroux Peter
Published: January 2015

The ability of flavoenzymes to reduce dioxygen varies greatly, and is controlled by the protein environment, which may cause either a rapid reaction (oxidases) or a sluggish reaction (dehydrogenases). Previously, a ‘gatekeeper’ amino acid residue was identified that controls the reactivity to dioxygen in proteins from the vanillyl alcohol oxidase superfamily of flavoenzymes. We have identified an alternative gatekeeper residue that similarly controls dioxygen reactivity in the grass pollen allergen Phl p 4, a member of this superfamily that has glucose dehydrogenase activity and the highest redox potential measured in a flavoenzyme. A substitution at the alternative gatekeeper site (I153V) transformed the enzyme into an efficient oxidase by increasing dioxygen reactivity by a factor of 60 000. An inverse exchange (V169I) in the structurally related berberine bridge enzyme (BBE) decreased its dioxygen reactivity by a factor of 500. Structural and biochemical characterization of these and additional variants showed that our model enzymes possess a cavity that binds an anion and resembles the ‘oxyanion hole’ in the proximity of the flavin ring. We showed also that steric control of access to this site is the most important parameter affecting dioxygen reactivity in BBE‐like enzymes. Analysis of flavin‐dependent oxidases from other superfamilies revealed similar structural features, suggesting that dioxygen reactivity may be governed by a common mechanistic principle.

Database

Structural data are available in PDB database under the accession numbers 4PVE, 4PVH, 4PVJ, 4PVK, 4PWB, 4PWC and 4PZF .
Hurricanes accelerated the Florida–Bahamas lionfish invasion
Authors: Johnston Matthew W. , Purkis Sam J.
Published: January 2015

In this study, we demonstrate how perturbations to the Florida Current caused by hurricanes are relevant to the spread of invasive lionfish from Florida to the Bahamas. Without such perturbations, this current represents a potential barrier to the transport of planktonic lionfish eggs and larvae across the Straits of Florida. We further show that once lionfish became established in the Bahamas, hurricanes significantly hastened their spread through the island chain. We gain these insights through: (1) an analysis of the direction and velocity of simulated ocean currents during the passage of hurricanes through the Florida Straits and (2) the development of a biophysical model that incorporates the tolerances of lionfish to ocean climate, their reproductive strategy, and duration that the larvae remain viable in the water column. On the basis of this work, we identify 23 occasions between the years 1992 and 2006 in which lionfish were provided the opportunity to breach the Florida Current. We also find that hurricanes during this period increased the rate of spread of lionfish through the Bahamas by more than 45% and magnified its population by at least 15%. Beyond invasive lionfish, we suggest that extreme weather events such as hurricanes likely help to homogenize the gene pool for all Caribbean marine species susceptible to transport.
Pasting and rheological properties of quinoa‐oat composites
Authors: Inglett George E. , Chen Diejun , Liu Sean X.
Published: January 2015

Quinoa (Chenopodium, quinoa) flour, known for its essential amino acids, was composited with oat products containing β‐glucan known for lowering blood cholesterol and preventing heart disease. Quinoa–oat composites were developed and evaluated for their pasting and rheological properties by a Rapid Visco Analyzer (RVA) and an advanced rheometer. All quinoa–oat composites showed increased pasting viscosities with increases in oat contents. The elastic modulus G′ and viscous modulus G″ for all quinoa–oat composites were higher than quinoa, suggesting that oat products increased the viscous properties of composites. Shear‐thinning properties were observed for all the composites. Improved water‐holding capacities (WHC) were found for the composites containing quinoa with nutrim or oat bran concentrate compared to quinoa alone. All the WHC of quinoa–oat composites were increased with the higher amounts of oat components. These quinoa–oat composites have improved nutritional value and texture qualities suitable for functional food applications.
La inspección del trabajo en la China contemporánea: no exactamente el modelo anglosajón
Authors: ZHUANG Wenjia , NGOK Kinglun
Published: January 2015

Los autores constatan la falta de control del cumplimiento del creciente número de leyes laborales aprobadas en China, que explican por la evolución del sistema de inspección desde los años ochenta hasta hoy. Este sistema ha tomado del modelo anglosajón el carácter fragmentado y el enfoque reactivo, pero es muy selectivo y carece de medidas coercitivas. Ello se deriva de la combinación de reformas neoliberales con el legado leninista del régimen autoritario. Para aumentar el nivel de cumplimiento se requeriría más cooperación tripartita en el proceso de inspección y la participación de organizaciones sindicales independientes.
Injusticia, conflicto y descontento social ante los accidentes y enfermedades profesionales en China
Authors: ZHU Ying , CHEN Peter Y. , ZHAO Wei
Published: January 2015

Ante el número desproporcionado de accidentes y enfermedades profesionales en China en el último decenio y el nivel de conflicto social que han generado, los autores investigan cómo los actores clave afrontan los problemas de seguridad y salud en el trabajo (SST) mediante entrevistas a 25 trabajadores lesionados o enfermos de cinco provincias chinas sobre prácticas de seguridad, causas potenciales de lesiones y tratamiento e indemnizaciones proporcionados (o no); además, formulan recomendaciones para mejorar la cultura de la seguridad empresarial en China, en aras de la justicia social y la armonía social.
Prevalence, Awareness, Treatment, and Control of Hypertension in Lebanon
Authors: Matar Dany , Frangieh Antonio H. , Abouassi Samah , Bteich Fernand , Saleh Aline , Salame Elie , Kassab Roland , Azar Rabih R.
Published: January 2015

The prevalence and factors related to hypertension (HTN) treatment and control are well investigated in the Western world but remain poorly understood in the Middle East and in middle‐income countries such as Lebanon. In order to measure the prevalence, awareness, treatment, and control rates of HTN in Lebanon, the authors measured blood pressure (BP) in 1697 adults. The prevalence of optimal BP (<120/80 mm Hg) was 33% and that of pre‐HTN (BP ≥120/80 mm Hg but <140/90 mm Hg) was 30%. The prevalence, awareness, treatment, and control (among treated hypertensive) rates of HTN were 36.9%, 53%, 48.9%, and 54.2%, respectively. Overall, only 27% of patients with HTN had their BP under control. Awareness was the most important predictor of treatment. No predictor of control could be identified. The authors concluded that HTN is prevalent in Lebanon and its overall control is low. Improving awareness is the most important target for intervention.
Financial Education and Savings Outcomes for Low‐Income IDA Participants: Does Age Make a Difference?
Authors: GRINSTEIN‐WEISS MICHAL , GUO SHENYANG , REINERTSON VANESSA , RUSSELL BLAIR
Published: January 2015

This study considers the impact of financial education dosage on savings outcomes of participants in Individual Development Account (IDA) programs. It analyzes data from a sample of approximately 2,000 participants in the American Dream Policy Demonstration, disaggregates outcomes by age, and uses propensity score modeling to control for endogeneity and selection bias. We find that, relative to counterparts who did not complete educational requirements, IDA participants who completed program requirements for financial education had higher average monthly savings, saved a higher portion of their income, and deposited savings more frequently. Notably, we find that participants aged 36 or older experienced increasing returns on investment in financial education, and the best outcomes are found among those with more than 200% of the required dose of financial education. However, younger participants with more than 100% of the required dose are found to experience a diminishing return on their investment in financial education.
Assessing the relative importance of methodological decisions in classifications of vegetation data
Authors: Lengyel Attila , Podani János
Published: January 2015

Questions

What is the relative importance of our methodological decisions concerning sampling (plot size) and data analysis (data transformation, resemblance coefficient, hierarchical clustering strategy and number of clusters) in vegetation classification? Are there differences between the conclusions when the full range or only a more practical narrow range of methodological choices is tested? What is the difference between results for actual and random data?

Location

Rock grassland in Hungary.

Methods

The full procedure of vegetation classification was simulated using actual and random data. Variation in classification results was partitioned using distance‐based redundancy analysis. The RDA models were subjected to variation partitioning to determine the relative importance of methodological decisions.

Results

RDA models explained more variation in classifications of random than in real data. Classification algorithm, cluster level, data transformation and mean plot size were always included among the most significant variables, however, the other variables also had a considerable effect in certain situations.

Conclusions

As adjusted R2 values suggest, the overall effect of methodological decisions on classifications is larger for randomly structured than actual data, due possibly to a stronger clustering tendency in the latter. The clustering algorithm, cluster level, data transformation and plot size should be chosen most carefully before classification analyses, but any of the examined decisions can significantly affect the result. In addition to the mean, the range of plot sizes should also be carefully delimited during relevé selection for classification studies. The main decision about the classification algorithm is whether a chain‐forming or group‐forming method is used. The data transformation had a more significant effect on real data than on simulations with random variation, thus supporting the ability of the application of different abundance scales in revealing different facets of biologically relevant patterns in community composition. The resemblance measure had a relatively weak effect, suggesting that it is not as influential as previously thought.
Long‐term changes in marsh vegetation in Sanjiang Plain, northeast China
Authors: Lou Yanjing , Zhao Kuiyi , Wang Guoping , Jiang Ming , Lu Xianguo , Rydin Håkan
Published: January 2015

Questions

Is there a consistent change in species composition and species richness across the communities along the wetness zonation? Which species are sensitive to environmental changes? Has species richness increased or decreased? What are the relative effects of climate, geographical position and local environmental factors on the inland marsh community?

Location

Sanjiang Plain, northeast China (130–133° E, 45–48° N).

Methods

A total of 94 plots were re‐surveyed in 2012 and compared with data from 1973. Detrended correspondence analysis (DCA) and indicator species analysis were used to analyse the direction and nature of change in community composition between 1973 and 2012. Paired t‐test was used to test for change in species richness, water level and soil variables between the two surveys. Correlation and step‐wise regression analyses were used to test the relationship between vegetation change (species richness and DCA scores), environmental variables and geographic position.

Results

Vegetation has changed towards a drier state, with the greatest changes in the wettest Carex lasiocarpa community and the smallest changes in the driest Calamagrostis angustifolia community. The frequency and cover of hygrophilous species and species typical of oligotrophic wetlands decreased, while grasses and other non‐marsh species increased. Species richness per community and per plot increased over time. The dynamics within each community was only weakly correlated with biogeographic predictors: longitude, latitude, elevation and annual precipitation.

Conclusions

Hydrology was the main factor controlling changes along the marsh zonation, and was most likely in response to climate warming and land‐use changes. The different responses among the marsh communities along the zonation and between hydrophytes and other species imply that future protection and management need to be based on community type and plant functional types.
Revisiting the Core of Our Good Government Ethos
Authors: Perry James L.
Published: January 2015

Perry Podcast Episode
Characteristics of particle size for creeping and saltating sand grains in aeolian transport
Authors: Cheng Hong , He Jiajia , Zou Xueyong , Li Jifeng , Liu Chenchen , Liu Bo , Zhang Chunlai , Wu Yongqiu , Kang Liqiang
Published: January 2015

Creep and saltation are the primary modes of surface transport involved in the fluid‐like movement of aeolian sands. Although numerous studies have focused on saltation, few studies have focused on creep, primarily because of the experimental difficulty and the limited amount of theoretical information available on this process. Grain size and its distribution characteristics are key controls on the modes of sand movement and their transport masses. Based on a series of wind tunnel experiments, this paper presents new data regarding the saltation flux, obtained using a flat sampler, and on the creeping mass, obtained using a specifically designed bed trap, associated with four friction velocities (0·41, 0·47, 0·55 and 0·61 m sec−1). These data yielded information regarding creeping and saltating sand grains and their particle size characteristics at various heights, which led to the following conclusions: (i) the creeping masses increased as a power function (q = −1·02 + 14·19u*3) of friction wind velocities, with a correlation (R2) of 0·95; (ii) the flux of aeolian sand flow decreases exponentially with increasing height (q = a exp(–z/b)) and increases as a power function (q = −26·30 + 428·40 u*3) of the friction wind velocity; (iii) the particle size of creeping sand grains is ca 1·15 times of the mean diameter of salting sand grains at a height of 0 to 2 cm, which is 1·14 times of the mean diameter of sand grains in a bed; and (iv) the mean diameter of saltating sand grains decreases rapidly with increasing height whereas, while at a given height, the mean diameter of saltating sand grains is positively correlated with the friction wind velocity. Although these results require additional experimental validation, they provide new information for modelling of aeolian sand transport processes.
Differential contributions of plant Dicer‐like proteins to antiviral defences against potato virus X in leaves and roots
Authors: Andika Ida Bagus , Maruyama Kazuyuki , Sun Liying , Kondo Hideki , Tamada Tetsuo , Suzuki Nobuhiro
Published: January 2015

Members of the plant Dicer‐like (DCL) protein family are the critical components of the RNA‐silencing pathway that mediates innate antiviral defence. The distinct antiviral role of each individual DCL protein has been established with mostly based on observations of aerial parts of plants. Thus, although the roots are closely associated with the life cycle of many plant viruses, little is known about the antiviral activities of DCL proteins in roots. We observed that antiviral silencing strongly inhibits potato virus X (PVX) replication in roots of some susceptible Solanaceae species. Silencing of the DCL4 homolog in Nicotiana benthamiana partially elevated PVX replication levels in roots. In Arabidopsis thaliana, which was originally considered a non‐host plant of PVX, high levels of PVX accumulation in inoculated leaves were achieved by inactivation of DCL4, while in the upper leaves and roots, it required the additional inactivation of DCL2. In transgenic A. thaliana carrying the PVX amplicon with a green fluorescent protein (GFP) gene insertion in the chromosome (AMP243 line), absence of DCL4 enabled high levels of PVX‐GFP accumulation in various aerial organs but not in the roots, suggesting that DCL4 is critical for intracellular antiviral silencing in shoots but not in roots, where it can be functionally compensated by other DCL proteins. Together, the high level of functional redundancies among DCL proteins may contribute to the potent antiviral activities against PVX replication in roots.
Molecular Underpinnings of Synaptic Vesicle Pool Heterogeneity
Authors: Crawford Devon C. , Kavalali Ege T.
Published: January 2015

Neuronal communication relies on chemical synaptic transmission for information transfer and processing. Chemical neurotransmission is initiated by synaptic vesicle fusion with the presynaptic active zone resulting in release of neurotransmitters. Classical models have assumed that all synaptic vesicles within a synapse have the same potential to fuse under different functional contexts. In this model, functional differences among synaptic vesicle populations are ascribed to their spatial distribution in the synapse with respect to the active zone. Emerging evidence suggests, however, that synaptic vesicles are not a homogenous population of organelles, and they possess intrinsic molecular differences and differential interaction partners. Recent studies have reported a diverse array of synaptic molecules that selectively regulate synaptic vesicles' ability to fuse synchronously and asynchronously in response to action potentials or spontaneously irrespective of action potentials. Here we discuss these molecular mediators of vesicle pool heterogeneity that are found on the synaptic vesicle membrane, on the presynaptic plasma membrane, or within the cytosol and consider some of the functional consequences of this diversity. This emerging molecular framework presents novel avenues to probe synaptic function and uncover how synaptic vesicle pools impact neuronal signaling.
Tariff‐tax Reforms in Large Economies
Authors: Ganelli Giovanni , Tervala Juha
Published: January 2015

This paper studies tariff‐tax reforms in a two‐region global New Keynesian model composed of a developing and an advanced region. In our baseline calibration, a revenue‐neutral reform that lowers tariffs in developing countries can reduce domestic welfare. The reason is that the increase in developing countries welfare due to higher output is dominated by the welfare losses stemming from the deterioration of the terms of trade. On the other hand, the reform increases output and welfare in the advanced countries and in the world as a whole. The effects that we highlight have not been studied in previous contributions to the literature, which looks at tariff‐tax reforms using a small open economy framework. Nominal rigidities have important implications for adjustment dynamics in our model. In the case of a ‘point‐for‐point’ reform, for example, price stickiness implies that the international dynamics of output is reversed compared to a revenue‐neutral reform.
The 24th annual meeting of the European Tissue Repair Society (ETRS) in Edinburgh, Scotland
Authors: Shaw Tanya J. , Lippens Evi
Published: January 2015

From the 10th to 12th of September 2014, in the midst of the Scottish Independence debate, the European Tissue Repair Society descended on Edinburgh for their 24th Annual Meeting. In the beautiful and historic setting of the Royal College of Surgeons of Scotland, Professors David Thomas (Chair), Phil Stephens, Chris Lloyd, and their teams from Cardiff hosted an educational and inspiring program.
Prediction of the niche effect for single flat panels with or without attached sound absorbing materials
Authors: Sgard Franck , Atalla Noureddine , Nélisse Hugues
Published: January 2015

The sound transmission loss (STL) of a test sample measured in sound transmission facilities is affected by the opening in which it is located. This is called the niche effect. This paper uses a modal approach to study the STL of a rectangular plate with or without an attached porous material located inside a box-shaped niche. The porous material is modeled as a limp equivalent fluid. The proposed model is validated by comparison with finite element/boundary element computations. Using a condensation of the pressure fields in the niche, the niche effect is interpreted in terms of a modification of the modal blocked pressure fields acting on the panel induced by the front cavity and by a modification of the radiation efficiency of the panel modes due to the presence of the back cavity. The modal approach is then used to investigate the impact of (1) the presence of a porous material attached to the panel on the niche effect and (2) the niche effect on the assessment of the porous material insertion loss. A simplified model for the porous material based on a transfer matrix approach is also proposed to predict the STL of the system and its validity is discussed.