bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EXAMINATION OF THE IMPACT OF CUSTOMER VALUE ON CONSUMER BEHAVIOR AMONG MINIMARKET RETAIL PATRONS IN THE JABODETABEK
Authors: Tiffany Abigael , Wijaya Niko Putra , Djahran Mohammad Ansara , Wijaya Lianna
Published: July 2024

Minimarkets represent a critical sector within the retail industry, playing a fundamental role in fulfilling the daily requirements of consumers, amidst a persistent uptrend in sales value. Within the progressively competitive commercial environment, the comprehension of Customer Value has emerged as a pivotal element in augmenting Satisfaction, consequently fostering customer Loyalty, which stands as a crucial component of Consumer Behavior and is essential for ensuring the continuity of business operations. The principal aim of this research is to examine the influence of Customer Value on Consumer Behavior among minimarket customers in the Jabodetabek area. A total of 376 minimarket customers in Jabodetabek area were surveyed via an online questionnaire for data collection. The methodological approach utilized for data analysis involved the application of Structural Equation Modeling using SmartPLS 4.0. The results of hypothesis testing indicate that Customer Value factors such as Product Excellence, Service Excellence, Social Value, and Aesthetics play a crucial role in influencing customer Satisfaction. Nevertheless, the Efficiency dimension does not demonstrate a notable impact on Satisfaction. Furthermore, customer satisfaction plays a significant role in fostering customer loyalty. The conclusions drawn from this study emphasize the need for minimarket businesses to continuously assess customer satisfaction levels by leveraging Customer Value, in turn enhancing customer loyalty and nurturing more resilient links between minimarkets and consumers in the Jabodetabek region.
MENILIK KINERJA PEGAWAI KANTOR CAMAT DI NIAS SELATAN YANG DIPENGARUHI LINGKUNGAN KERJA DAN STRES KERJA
Authors: Duha Timotius
Published: July 2024

This research intends to find out how much the work environment and work stress influence the performance of sub-district office employees in South Nias. This research is quantitative in type. In this research, the population came from employees in three large sub-district offices in South Nias (Telukdalam, Fanayama, and Amandraya). The sample used was total sampling. So the total sample is 8219 people. Data collection is through distributing questionnaires which are then filled in with answers by respondents. Data analysis uses multiple linear regression. Research findings show: partially or simultaneously, the two independent variables have a positive influence on the dependent variable. The main recommendation for this research is the need to add other topics that can increase performance, such as job satisfaction.
Modelo de valoración financiera “VALORFIN” para una pequeña y mediana empresa (PYME) en Ecuador
Authors: Molina-Martínez Ruben , Peñaloza-López Verónica
Published: July 2024

Este artículo presenta un modelo de valoración financiera diseñado específicamente para abordar las necesidades particulares de las PYME en el contexto empresarial ecuatoriano. El objetivo fundamental de esta investigación es proponer un enfoque integral que ofrezca un valor realista y preciso de estas empresas, llenando así una brecha crítica en la metodología de valoración financiera adaptada a la realidad de nuestro país. El modelo propuesto contiene una estrategia interdisciplinaria, analizando proyecciones de flujo de efectivo desde la perspectiva de la descriptiva, análisis de las empresas por medio de referencias de transacciones de mercado comparativo. Este enfoque holístico tiene como objetivo superar las limitaciones intrínsecas de los modelos genéricos, ajustándose específicamente a las dinámicas únicas del mercado ecuatoriano. La importancia de este enfoque radica en su capacidad para proporcionar no solo una valoración más precisa y contextualizada de estas empresas, sino también en contribuir a la toma de decisiones estratégicas, la planificación financiera y la evaluación del rendimiento empresarial en Ecuador. Al proponer un modelo que refleje de manera más precisa la realidad empresarial en el país, se espera que esta investigación tenga un impacto significativo en la práctica financiera y empresarial en Ecuador, mejorando la eficiencia y la precisión en la valoración de las PYMEs y, por ende, fortaleciendo el tejido empresarial del país.
El tipo penal de contrabando y su incidencia actual en el derecho penal y procesal ecuatoriano
Authors: Andrade-Borja Jorge
Published: July 2024

El Código Orgánico Integral Penal, en su artículo 301 describe la conducta por la cual penaliza el delito de contrabando.  
El delito de contrabando, sanciona el hecho de ingresar mercadería que no tenga los respectivos respaldos de propiedad que legitimen su licitud. Por la redacción del tipo penal tiene varias circunstancias novedosas, por ejemplo, la obligación de presentar los documentos que legitimen la propiedad, las zonas de frontera, el tiempo para empezar la acción penal, etc. Cuyo bien jurídico protegido radica en la economía estatal. 
Como está configurado el tipo penal no violenta la presunción de inocencia en el apartado de justificar la licitud de la mercadería, puesto que dicha carga probatoria siempre estará en manos de Fiscalía; ahora bien, el tipo penal tiene un presupuesto de procedibilidad en el entendido de esperar 72 horas para iniciar el proceso penal, lo que permite la no existencia de un proceso penal con modalidad de flagrancia.
Fortalecimiento del aprendizaje significativo en estudiantes de bachillerato técnico en Informática utilizando una metodología activa que tiene como base el aula invertida
Authors: Clavijo-Cortes Rosa , Cuzco-Gordillo Jorge , Chiquito-Chilan Rosa
Published: July 2024

El proyecto de investigación sobre el aprendizaje significativo en los estudiantes de Informática utilizando el aula invertida (Flipped Classroom), tiene como propósito aplicar una metodología activa que fortalezca el modelo de enseñanza en el Colegio de Bachillerato Ricaurte. ¿De qué manera la aplicación del método de aula invertida fortalece el aprendizaje significativo en los estudiantes de Informática dentro del proceso de enseñanza aprendizaje?  es la interrogante que permite dar vuelta a la enseñanza tradicional de manera innovadora y didáctica por medio de herramientas tecnológicas y de tal forma permitió analizar la teoría de diferentes autores basándose en enfoques cuantitativo y cualitativo, el tipo de investigación empírica permitió obtener información  verificando por  medios de encuestas, entrevistas, se tomó como población a 310 estudiantes del bachillerato técnico FIP Informática, 6 docentes del área en mención, se entrevistó al vicerrector de la institución educativa, la muestra fueron 90 estudiantes de primero de bachillerato, utilizando un muestreo intencional no probabilístico a criterio de los autores, se utilizó la técnica  de observación para diagnosticar la metodología y el aprendizaje significativo en los educandos como resultado los profesores imparten el módulo formativo de Sistemas Operativos y Redes I de forma tradicional, por lo tanto, no se evidencia un aprendizaje significativo, es por esta razón que se propuso la utilización de la plataforma Classroom para que los estudiantes interactúen en casa, se concluyó que la metodología de aula invertida fortalecerá el aprendizaje significativo.
El desarrollo de la escritura creativa a través de la redacción de cuentos en los estudiantes del tercer año de Educación General Básica Elemental EGBE
Authors: Robles-Ochoa María , Samaniego-Rivadeneira Mónica
Published: July 2024

El propósito de este estudio científico es examinar en detalle cómo la redacción de cuentos puede tener un impacto significativo en el desarrollo de la escritura creativa de los estudiantes que están en el tercer año de Educación General Básica Elemental. La investigación se centra en examinar la relación entre la práctica regular de la redacción de cuentos y los avances observados en las habilidades de expresión escrita, creatividad y comprensión literaria en este grupo específico de estudiantes. Para llevar a cabo este estudio, se utilizó un enfoque longitudinal que incluyó el análisis exhaustivo de muestras de escritura y la evaluación exhaustiva de la creatividad, junto con encuestas diseñadas meticulosamente. El objetivo principal de este método fue obtener una comprensión completa y multifacética de cómo han cambiado las habilidades de escritura creativa a lo largo del tiempo. 
La guía metodológica se enfoca en fomentar la habilidad de escribir creativamente en los estudiantes de tercer año de educación básica a través de un enfoque estructurado.
Análisis de la satisfacción estudiantil de acuerdo con el nivel académico del profesorado de un Instituto de Educación Superior
Authors: Almeida-Herrera Lisbeth , Freire-Renjifo Danilo
Published: July 2024

El estudio aborda la satisfacción estudiantil en instituciones de educación superior técnica y tecnológica, enfocándose en cómo el nivel académico del profesorado afecta esta percepción. Utilizando un diseño cuantitativo, se aplicó un cuestionario que evaluó aspectos como la calidad de la enseñanza y la formación académica de los docentes. Los resultados indican que los títulos avanzados de los profesores, como maestrías y doctorados, contribuyen positivamente a la percepción de competencia del profesorado. Sin embargo, se destaca que factores como la habilidad de los docentes para establecer conexiones significativas con los estudiantes y adaptar su enseñanza a necesidades individuales son igualmente cruciales para la satisfacción estudiantil. Esta investigación resalta la importancia de integrar una sólida formación académica con efectivas habilidades pedagógicas para elevar la calidad educativa. También se menciona la necesidad de realizar más estudios que aborden desafíos como el estrés escolar y la deserción, y que busquen mejorar la infraestructura y los servicios de apoyo para crear un entorno educativo que satisfaga las expectativas y necesidades de los estudiantes.
Costes reales en el sector alimentario: un acercamiento sistemático a las metodologías aplicadas
Authors: Tapia-Guato Nallely , Pilaguano-Patango Freddy , Hurtado-García Ketty , Ulloa-Méndez Carmen
Published: July 2024

El problema de los costes reales en el sector alimentario radica en la falta de un enfoque sistemático y metodologías consistentes para evaluar y gestionar los costes asociados a la producción, distribución y comercialización de alimentos. El propósito general de la investigación radicó en explorar diferentes evaluaciones de la contabilidad de costos reales y destacar el nivel actual de superposición y diferencias entre los marcos existentes. La investigación se estructura en torno a un enfoque sistemático que abarca desde la identificación y clasificación de los diversos tipos de costes hasta la evaluación de su impacto en la cadena de valor alimentaria. Se explorarán metodologías aplicadas en la determinación de costes, destacando las mejores prácticas y proporcionando recomendaciones para una implementación eficiente. La elección del enfoque cualitativo en la investigación se justifica por la necesidad de comprender en profundidad las complejidades y matices asociados a los costes en este sector. La muestra de estudio constó de un total de 43 artículos científicos procedentes de diversas fuentes. Los resultados evidenciaron que una serie de diferencias más fundamentales entre las metodologías de la contabilidad de costos reales se relacionan con opciones de valores integrales a la estructura de los marcos, en particular los efectos directos e indirectos, las dimensiones de bienestar y la agregación. Finalmente se concluye que, la adopción de la contabilidad de costos reales todavía está limitada por la madurez de sus métodos. Al mismo tiempo, se desarrolla en demasiadas direcciones como para que los resultados sean comparables entre diferentes análisis.
Enigmas del entorno político en la gestión financiera del sector cooperativista del segmento 1 a partir del método CAMEL
Authors: Sánchez-Ortega Gardenia , Sigcha-Santacruz Angela , Reyes-Armas Rodrigo , Oña-Sinchiguano Brenda
Published: July 2024

El entorno político es un factor importante en la configuración de las políticas económicas y financieras de cualquier sector, en este caso incluidas las COAC. Ante lo expuesto, el objetivo de la investigación radica en analizar el efecto de los enigmas del entorno político mediante el método CAMEL para el reconocimiento de la gestión financiera organizacional de las COAC ecuatorianas del segmento 1. La metodología que se utilizó tuvo un enfoque cuantitativo, ya que surge de la necesidad de una evaluación objetiva y mensurable del impacto del entorno político en la gestión financiera de las cooperativas. Este enfoque permite el uso del método CAMEL, una herramienta analítica estructurada y rigurosa ideal para medir y comparar de forma precisa y cuantitativa métricas sobre capital, activos, gestión, rentabilidad y liquidez. Además, se usó un método documental y correlacional. Como muestra de estudio se tomó en cuenta a cooperativas ecuatorianas del segmento 1 (28). Los datos obtenidos fueron procesados a través del software estadístico Spss y Microsoft Excel. Los resultados arrojaron que los principales indicadores macroeconómicos de Ecuador entre el año 2018 – 2021 destacando cambios significativos por lo que, es notable que el Producto Interno Bruto del sector financiero alcanzó su máxima contribución al PIB total del país en el año 2019. En contraste, la inflación alcanzó su nivel más alto en el año 2018 con un 9,80%.
Incidencia de los tributos por comercio exterior en las finanzas de Ecuador periodo 2019-2023
Authors: Granja-Chiriboga Miguel , Gallegos-Vargas Mayra , Carrión-Aguilar Rodrigo , Hablich-Sanchez Felix
Published: July 2024

El objetivo de la investigación es analizar el impacto que generan los ingresos provenientes de tributos por importación en las finanzas del Ecuador, en los años 2019-2023; las variables que se analizan permiten determinar el nivel de ingresos tributarios que el país destina al financiamiento del Presupuesto General del Estado, provenientes de impuestos que se aplican a las importaciones. Las variables que se analizan, son: en calidad de variable dependiente, al Presupuesto General del Estado; en calidad de variable independiente a los tributos por importación; la muestra seleccionada permite evaluar el nivel de dependencia que mantienen las finanzas del estado por apalancamiento de los ingresos proveniente de las actividades comerciales de importación; considerando: al impuesto al valor agregado (IVA),  impuesto a la salida de divisas (ISD) y al impuesto a los consumos especiales (ICE), los indicadores que componen las variable independiente generan cambios en le presupuesto. El método que se utiliza permite desarrollar el esquema para alcanzar el objetivo propuesto;  mediante la investigación documental y descriptiva, debido a que comprende un proceso basado en la búsqueda de información para la comparación de datos establecidos, las fuentes de información que se escogen para el análisis de la investigación son, las estadísticas publicadas por el Servicio de Rentas Internas (SRI) el Ministerio de Economía y Finanzas del Ecuador, otras fuentes de información proporcionada por investigadores que realizaron análisis paralelos. La investigación tiene un alcance descriptivo, porque permite determinar cómo contribuye el comercio exterior en el apalancamiento de las finanzas del estado. Explica que el incremento de la recaudación tributaria por impuestos, aplicados a las importaciones es el reflejo de un crecimiento de las importaciones en el periodo de análisis.
Kepemimpinan Transformasional Kepala Sekolah dalam Meningkatkan Motivasi dan Komitmen Guru
Authors: Sabariah Sabariah , Khair Abdul , Hizri Muhammad , Rufi’i Rufi’i , Sulistiami Sulistiami , Rahmi Agustina
Published: July 2024

The aim of the research is to explain and describe transformational leadership as being able to increase teacher motivation and commitment at Madrasah Aliyah Negeri 5 Banjar. The research method is qualitative through a case study approach. Data collection techniques using online questionnaires using Google forms, documentation and observation. Data processing techniques using data collection, reduction, data presentation and drawing conclusions. Data validity techniques with credibility and confirmability. The research results show: (1) transformational leadership: idealized Influence: having a vision and mission, feeling proud, getting attention and trust from teachers. Inspirational Motivation, able to inspire, give an example and motivate teachers to develop. Intellectual Stimulation, increasing teacher creativity and innovation, increasing rationality and problem solving. Individualized Consideration, treating teachers fairly, providing teacher assistance, monitoring and supervision. (2) transformational leadership style is able to increase teacher motivation, such as enthusiasm for carrying out tasks, responsibility, ability to create new ideas. (3) transformational leadership style is able to increase teacher commitment, such as involving teachers in official meetings, training and teacher forums
Manajemen Program Ekstrakurikuler dalam Meningkatkan Prestasi Non Akademik Peserta Didik
Authors: Priyanto Arwan Adik , Kurniawan Benny , Muhyidin Muhyidin
Published: July 2024

This research aims to explore the role of extracurricular management in improving non-academic achievements of students at SMK Ma'arif 6 Ayah Kebumen, focusing on supporting and inhibiting factors. A qualitative approach was employed, involving in-depth interviews with extracurricular managers, teacher advisors, and active participants in extracurricular activities. The main problem formulation of this research is how extracurricular management operates at SMK Ma'arif 6 Ayah Kebumen and what factors act as supporters or inhibitors in its implementation. The results indicate that extracurricular management at SMK Ma'arif 6 Ayah Kebumen has various supporting factors, such as commitment from managers, active participation from students, school support, and resource availability. However, several inhibiting factors were also identified, including resource limitations, inadequate training for teacher advisors, and challenges in planning and coordinating activities. To enhance the effectiveness of extracurricular management, this study recommends improvements in resource management, increased training for teacher advisors, and enhanced coordination between extracurricular managers and the school administration. These efforts are expected to optimize the contribution of extracurricular activities in enhancing the non-academic achievements of students at SMK Ma'arif 6 Ayah Kebumen
Immune Complex-Mediated Membranoproliferative Glomerulonephritis Secondary to Primary Biliary Cholangitis: A Rare Case Report
Authors: Intas Kadir , Okyay Gulay , Saglam Arzu , Ayli Mehmet
Published: July 2024

Immune complex-mediated membranoproliferative glomerulonephritis (iMPGN) can develop in association with autoimmune diseases such as primary biliary cholangitis (PBC), a chronic cholestatic liver disease characterised by destruction of the small and medium-sized bile ducts. Although the pathogenesis cannot be clearly defined, iMPGN and PBC overlap through the activation of innate and adaptive immune cells and the production of proinflammatory mediators. In this report, the authors present a case in which iMPGN and PBC were diagnosed simultaneously.
Mayfly optimistic hyperelliptic curve cryptosystem
Authors: Nava Teja Reddy Ramireddy , Kavitha M. , Reddy G. Sudarsana , Yousef Amr , AboRas Kareem M. , Emara Ahmed , Reddy Ch. Rami
Published: July 2024

Various applications use asymmetric cryptography to secure communications between both parties, and it raises the main issue of generating vast amounts of computation and storage. Thus, elliptic curve cryptography (ECC) is a methodology that emerged to overcome this issue using its low computation and generation of small keys with its strong encryption strategy. ECC is becoming mandatory and used mostly for public key encryption protocols. ECC has expanded cumulative acceptance in practice due to the reduced bit magnitude of operands compared to RSA for safety level. Previously, protocols designed for ECC suggested calculation of scalar development and it was accomplished in finite fields as projective, affine, and Jacobian simulations of coordinates. Arithmetic operations in a limited area establish the core benefits of the ECC algorithm. Even though ECC generated an issue of complex key generation using its curve formation, to overcome this issue a hyperelliptic curve cryptosystems (HECC) is proposed in this study. HECC perform ECC in the Public Key Cryptography (PKC) domain. This study presented an optimization-based key generation and made a random selection of integers for encrypting the message. Selecting a prime number as the private key and multiplying it to the encrypted message to generate a public key is done. This encrypted message is mapped to the curve to check whether it satisfies the curve equation or not. Once an encrypted message is obtained, it is then sent to a second party for pursuing the message. On the side of the second party, a reverse process called decryption takes place. Thus, a secured transmission of data communication takes place. Implementing this algorithm in MATLAB resulted in 94% accuracy and an error of 6%, which was a higher performance ratio than previous methods.
Possible role of QRS duration in the right ventricle as a perioperative monitoring parameter for right ventricular function: a prospective cohort analysis in robotic mitral valve surgery
Authors: Watanabe Ryota , Hori Kotaro , Ishihara Keisuke , Tsujikawa Shogo , Hino Hideki , Matsuura Tadashi , Takahashi Yosuke , Shibata Toshihiko , Mori Takashi
Published: July 2024

Background

The clinical importance of the right ventricle (RV) has recently been recognized; however, assessing its function during cardiac surgery remains challenging owing to its complex anatomy. A temporary transvenous pacing catheter is a useful tool in the small surgical field of minimally invasive cardiac surgery, and an electrocardiogram recorded through the catheter is composed of the direct electrophysiological activity of the RV. Therefore, we hypothesized that QRS duration in the RV (QRSRV) could be a useful monitoring parameter for perioperative RV function.

Methods

We conducted a prospective cohort analysis involving adult patients undergoing robotic mitral valve repair. A bipolar pacing catheter was inserted using x-ray fluoroscopy, and the QRSRV duration was assessed at four time points: preoperative baseline, during one-lung ventilation, after weaning from cardiopulmonary bypass, and before the end of surgery. At the same time points, right ventricular fractional area change (RVFAC) measured by transesophageal echocardiography and QRS duration at V5 lead of the body surface electrocardiogram (QRSV5) were also evaluated.

Results

In the 94 patients analyzed, QRSRV duration was significantly prolonged during robotic mitral valve repair (p = 0.0009), whereas no significant intraoperative changes in RVFAC were observed (p = 0.2). By contrast, QRSV5 duration was significantly shortened during surgery (p < 0.00001). Multilinear regression showed a significant correlation of QRSRV duration with RVFAC (p = 0.00006), but not with central venous pressure (p = 0.9), or left ventricular ejection fraction (p = 0.3). When patients were divided into two groups by postoperative QRSRV > 100 or ≤100 ms, 25 patients (26.6%) exhibited the prolonged QRSRV duration, and the mean increase in the postoperative QRSRV from preoperative baseline was 12 ms (p = 0.001), which was only 0.6 ms in patients with QRSRV ≤ 100 ms (p = 0.6). Cox regression analysis showed that prolonged postoperative QRSRV duration was the only significant parameter associated with a longer ICU stay after surgery (p = 0.02; hazard ratio, 0.55).

Conclusion

Our data suggest that QRSRV duration is a useful parameter for monitoring the RV during cardiac surgery, possibly better than a commonly used echocardiographic parameter, RVFAC. An electrophysiological assessment by QRSRV duration could be a practical tool for the complex anatomy of the RV, especially with limited modalities in perioperative settings.
Preservation of intergranular pore in deep clastic reservoirs by rock fabric based on compaction physics simulation experiments
Authors: Guo Huajun , Wang Daoshen , Shan Xiang , Peng Bo , Zou Zhiwen , Wu Jin , Li Ke
Published: July 2024

Diagenetic physical simulation is a reliable means to study patterns of pore evolution and variations of physical properties, however, the current compaction model is mostly based on sandstone, and there is a lack of quantitative compaction and porosity reduction studies for more complex rock fabrics. In order to simulate the continuous change of intergranular porosity in the reservoir under compaction during the diagenesis of buried sedimentary strata, a self-designed diagenesis simulation experimental system was adopted. Using different modern sediment samples, the simulation experiment of mechanical compaction of glutenite was carried out. The experiment shows that during the process of mechanical compaction of glutenite, the change of porosity with depth is segmented, and there is a good logarithmic relationship between depth and porosity in the process of diagenetic compaction. The larger the grain size in the reservoir rock, the better the pore preservation capacity; When the sand particles fill the pores among gravel, stable secondary support structure formed by gravel and sand grades can effectively take over the bearing pressure, and when the sand-grade particle content is about 30%, the pressure-bearing capacity is the strongest; Intergranular heterobase filling is greater in samples with high heterobase content, high heterobasic content is not favourable to the preservation of primary pores. This study provides favorable experimental support for the preservation mechanism of deep clastic reservoir pores, and has important theoretical and practical significance for oil and gas exploration in the study area. The use of simulation experiment provides a useful idea for the evaluation and prediction of reservoirs and the search for favorable reservoir development zones in the future.
The CABANA model 2017–2022: research and training synergy to facilitate bioinformatics applications in Latin America
Authors: Campos-Sánchez Rebeca , Willis Ian , Gopalasingam Piraveen , López-Juárez Daniel , Cristancho Marco , Brooksbank Cath ,   on behalf of The CABANA Consortium
Published: July 2024

The CABANA project (Capacity Building for Bioinformatics in Latin America) was funded by the UK’s Global Challenges Research Fund in 2017 with the aim to strengthen the bioinformatics capacity and extend its applications in Latin America focused on three challenge areas – communicable diseases, sustainable food production and protection of biodiversity. For 5 years, the project executed activities including data analysis workshops, train-the-trainer workshops, secondments, eLearning development, knowledge exchange meetings, and research projects in 10 countries. The project was successful in accomplishing all its goals with a major impact on the region. It became a model by which the research needs determined the training that was delivered. Multiple publications and over 800 trainees are part of the legacy of the project.
Association of remnant cholesterol with renal function and its progression in patients with type 2 diabetes related chronic kidney disease
Authors: Li Qiuhong , Wang Tongdan , Shao Xian , Fan Xiaoguang , Lin Yao , Cui Zhuang , Liu Hongyan , Zhou Saijun , Yu Pei
Published: July 2024

Background

The association of Remnant cholesterol (RC) with renal function and its progression in patients with Type 2 diabetes (T2DM) related chronic kidney disease (CKD) remains unclear.

Methods

8,678 patients with T2DM-related CKD were included in cross-sectional analysis, and 6,165 patients were enrolled in longitudinal analysis and followed up for a median of 36.0 months. The outcomes were renal composite endpoint event and rapid progression of renal function.

Results

24.54% developed a renal composite endpoint event, and 27.64% rapid progression of renal function. RC levels above 0.56 mmol/L independently increased the risk of both renal composite endpoint (HR, 1.17; 95% CIs, 1.03-1.33) and rapid progression of renal function (OR, 1.17; 95% CIs, 1.01- 1.37). TG levels above 1.65 mmol/L only increased the risk of renal composite endpoint (HR, 1.16; 95% CIs, 1.02 -1.32). TC levels above 5.21 mmol/L increased the risk of renal composite endpoint (HR, 1.14; 95% CIs, 1.01-1.29) only in patients with proteinuria≥0.5g/d. Conversely, HDL-C levels below 1.20 mmol/L or above 1.84 mmol/L increased the risk of rapid progression of renal function (OR, 0.88; 95% CIs, 0.70 -0.99) in patients with proteinuria<0.5g/d (all P<0.05).

Conclusion

In patients with T2DM-related CKD, RC was an independent risk factor for progression of renal function, and maintaining it below 0.56 mmol/L could reduce the risk of renal function progression.
Rise in fasting and dynamic glucagon levels in children and adolescents with obesity is moderate in subjects with impaired fasting glucose but accentuated in subjects with impaired glucose tolerance or type 2 diabetes
Authors: Pixner Thomas , Chaikouskaya Tatsiana , Lauth Wanda , Zimmermann Georg , Mörwald Katharina , Lischka Julia , Furthner Dieter , Awender Elisabeth , Geiersberger Sabine , Maruszczak Katharina , Forslund Anders , Anderwald Christian-Heinz , Cadamuro Janne , Weghuber Daniel , Bergsten Peter
Published: July 2024

Background

Fasting levels of glucagon are known to be elevated in youth and adults with type 2 diabetes mellitus (T2D). Children and adolescents with obesity were previously reported to show increasing fasting and post-glucose-challenge hyperglucagonemia across the spectrum of glucose tolerance, while no data are available in those with impaired fasting glucose (IFG).

Materials and methods

Individuals from the Beta-JUDO study population (Uppsala and Salzburg 2010–2016) (n=101, age 13.3 ± 2.8, m/f =50/51) were included (90 with overweight or obesity, 11 with normal weight). Standardized OGTT were performed and plasma glucose, glucagon and insulin concentrations assessed at baseline, 5, 10, 15, 30, 60, 90 and 120 minutes. Patients were grouped according to their glycemic state in six groups with normal glucose metabolism (NGM) and normal weight (NG-NW), NGM with obesity or overweight (NG-O), impaired glucose tolerance (IGT), impaired fasting glucose (IFG), IGT+IFG and T2D, and in two groups with NGM and impaired glucose metabolism (IGM), for statistical analysis.

Results and conclusion

Glucagon concentrations were elevated in young normoglycemic individuals with overweight or obesity (NG-O) compared to normoglycemic individuals with normal weight. Glucagon levels, fasting and dynamic, increased with progressing glycemic deterioration, except in IFG, where levels were comparable to those in NG-O. All glycemic groups showed an overall suppression of glucagon during OGTT. An initial increase of glucagon could be observed in T2D. In T2D, glucagon showed a strong direct linear correlation with plasma glucose levels during OGTT. Glucagon in adolescents, as in adults, may play a role in the disease progression of T2D.
Relationship of weight-adjusted waist index and developmental disabilities in children 6 to 17 years of age: a cross-sectional study
Authors: Li Xueying , Zhou Qi
Published: July 2024

Purpose

The development of multiple system diseases is increased by obesity. However, the connection between obesity and developmental disabilities (DDs) in children is unclear. As an obesity index, the weight-adjusted waist index (WWI) assessed fat distribution and muscle mass. In this study, we examined the correlation between WWI and DDs among children 6 to 17 years of age.

Methods

This study used data from the National Health and Nutrition Examination Survey database (NHANES) covering 2003 to 2018, which included the data of 17,899 participants between 6 and 17 years of age. Data regarding their waist circumference, weight, and DDs were collected via physical examinations and questionnaire, respectively. A person’s WWI is calculated by dividing their waist circumference by their weight squared. The correlation between WWI and DDs was studied using weighted multiple logistic regression models. Additionally, a sensitivity analysis was conducted utilizing a generalized additive model and smooth curve fitting.

Results

After adjusting for all covariates, WWI was positively related to DDs in children ages 6-17. Based on the sensitivity analysis, the correlation between the WWI and prevalence of DDs remained consistent across subgroups. Additionally, there was a J-shaped correlation between the WWI and the prevalence of DDs in children ages 6 through 11.

Conclusion

Children 6–17 years of age with a high WWI were at greater risk for DDs; however, the causal relationships and potential mechanisms require further exploration.
Role of MicroRNA in linking diabetic retinal neurodegeneration and vascular degeneration
Authors: Zhao Haiyan , Cai Yichen , Pan Junhua , Chen Qiu
Published: July 2024

Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular degeneration are two primary pathological processes of diabetic retinopathy. The retinal nervous system and vascular cells have a close coupling relationship. The connection between neurodegeneration and vascular degeneration is not yet fully understood. Recent studies have found that microRNA plays a role in regulating diabetic retinal neurovascular degeneration and can help delay the progression of the disease. This article will review how microRNA acts as a bridge connecting diabetic retinal neurodegeneration and vascular degeneration, focusing on the mechanisms of apoptosis, oxidative stress, inflammation, and endothelial factors. The aim is to identify valuable targets for new research and clinical treatment of diabetic retinopathy.
Modelling and optimization of operating parameters for improved steam energy production in the food and beverage industry in a developing country
Authors: Olusanya Olamide O. , Onokwai Anthony O. , Anyaegbuna Benjamin E. , Iweriolor Sunday , Omoniyi Ezekiel B.
Published: July 2024

Efficient steam energy production was essential for reducing energy consumption and operational costs while enhancing productivity, particularly in industrial settings prone to explosions due to boiler parameter control issues. This challenge was especially acute in the food and beverage industry amid rising energy costs and stricter environmental regulations, highlighting the importance of optimizing steam energy production. This study focused on refining operational parameters in a steam production plant to maximize steam energy output. It utilized mathematical models and optimization tools to identify ideal operational conditions and investigate extreme scenarios. Design-Expert version 13.0 statistical software and Response Surface Methodology (RSM) via Centre Composite Design (CCD) were employed to create a comprehensive design matrix encompassing key variables like time, pressure levels, temperature, mass flow rate, and steam energy production across three experimental levels. The research revealed that increased pressure and time significantly boosted steam energy production by leveraging water’s energy content rise under initial conditions, thus improving efficiency by reducing required water mass circulation. Moreover, elevated temperature and extended operation enhanced economizer efficiency, leading to increased heat recovery and reduced steam generation. Steam generation also increased with temperature and time due to the pressure rise during boiling, necessitating more energy for steam conversion. An optimum yield of steam energy of 620 Cal was attained at a time, pressure, temperature, and mass flow rate of 1 h, 16.97 MPa, 249.5°C, and 59.85 kg/s, respectively. The mathematical model developed is accurate, reliable, responsive, and can replicate the experimental data due to the high F-value (24.48), low CV (0.94) low p-value (< 0.005), and high R2 (0.9821) value close to 1. This research promises to enhance the efficiency of steam energy production in the food and beverage industry by reducing the need for resource-intensive experimental procedures, thus lowering costs and resource consumption.
The comparison of the Bayesian method with the classical methods in modeling crown width for Prince Rupprecht larch in northern China
Authors: Hong Liang , Wang Mengxi , Feng Linyan , Duan Guangshuang , Fu Liyong , Wang Xiyue
Published: July 2024

Introduction

Crown width (CW) is a significant variable of tree growth, but measuring crown width is laborious and time-consuming. Diameter at breast height (D) is a commonly used growth variable in crown width prediction. Here, a CW-D model was developed to estimate the crown width of larch.

Methods

The data of 1,515 larch trees were collected in Guandi mountain, the northern China. We chose linear function, quadratic function, and other form of base functions to develop the CW models, and we introduced non-linear least squares techniques (NLS), non-linear mixed-effect (NLME), and Bayesian method in modeling process. Because the data was from different plot, we added a plot level random effect in NLME method to predict the effect from environment. For equally comparing the Bayesian method with the NLME, we also added the plot level random effect to the Bayesian MCMC procedure. We selected Akaike's information criterion and logarithm likelihood to evaluate NLS and NLME models, and chose deviance information criterion and stationary test to test Bayesian method. These methods had another three same indicators (the determination coefficient, root mean square error, and mean absolute deviation) in model evaluation.

Results and discussion

Heteroskedasticity wasn't occurred in this study. The model I.2 (quadratic formula) showed a best fitting effect in each method, and Bayesian method with random effect was slightly superior than other methods. Therefore, the selected final model was quadratic function by Bayesian method with plot level random effect, this combination had the highest prediction accuracy in the larch trees' crown width estimation of Guandi mountain.
Mechanistic analysis of the hardening process of the thorns on stems of Bougainvillea glabra “Elizabeth Angus”
Authors: Sun Lina , Wang Huaxin , Li Jinhua , Gong Jianying , Yang Shuting , Yang Kaitai , Chen Er , Li Bing , Lu Zhixiang , Chen Qi , Lin Mao
Published: July 2024

Introduction:Bougainvillea glabra “Elizabeth Angus“ is a thorny woody vine or shrub. However, the hard thorns are considered a deficiency in its ornamental value.

Methods: To find the genes and pathways related to the hardening process of the thorns on the stems of B. glabra, the eukaryotic unreferenced transcriptome sequencing analysis was conducted to explore the 3 stages of the thorn-hardening process. Total RNA was extracted from thorns and stems, and transcriptome libraries were constructed and sequenced using unreferenced Illumina sequencing.

Results: Gene function annotation was performed using various databases, resulting in 8937 co-annotated genes. The density distribution of Fragments Per Kilobase of transcript per Million mapped reads (FPKM) depicted the overall gene expression patterns. The study found that stage 2 as the period of highest gene expression activity during the thorns hardening process in B. glabra. Differential expression analysis revealed that during thorn-hardening, 1045 genes up-regulated and 391 genes down-regulated significantly in thorns at stage 2 compared to stage 1 (early stage of thorns formation). Meanwhile, 938 genes up-regulated and 784 genes down-regulated significantly in stems. At stage 3, as thorns became harder, 63 genes exhibited notable expression increase and 98 genes’ expression decreased obviously within thorns, and 46 genes up-regulated and 29 genes down-regulated in stems, compared to stage 2. Phenylpropanoid biosynthesis was the key step in the hardening process of the thorns of B. glabra. The formation and hardening of thorns on the stem of B. glabra was a process in which lignin gradually accumulated in the thorns, and several genes were involved in this process. They include PAL (EC:4.3.1.24), CYP73A (EC:1.14.14.91), 4CL (EC:6.2.1.12), CCR (EC:1.2.1.44), CAD (EC:1.1.1.195) and POX (EC:1.11.1.7).

Discussion: This transcriptome analysis offers insights into the molecular mechanisms underlying thorns development in this plant species.
Unraveling chromosomal and genotoxic damage in individuals occupationally exposed to coal from underground mining
Authors: Buitrago-Rodríguez María Yolanda , Rangel Nelson , Vega-Valderrama Juan D. , Pulido-Medellín Martín , Rondón-Lagos Milena
Published: July 2024

Purpose

Coal mining is a vital sector in Colombia, contributing significantly to the nation’s economy and the development of its regions. However, despite its importance, it has led to a gradual decline in the health of mine workers and nearby residents. While the adverse health effects of open-pit coal mining on exposed individuals have been well-documented in Colombia and globally, studies investigating genetic damage in underground coal miners are lacking.

Methods

The aim of our study was to evaluate chromosomal and genotoxic damage, in peripheral blood samples from a group of underground coal miners and residents of areas exposed to coal, in the town of Samacá, Boyacá-Colombia, and in a group of unexposed individuals by using banding and molecular cytogenetic techniques, as well as cytokinesis block micronucleus assays.

Results

Our results suggest that occupational exposure to coal induces chromosomal and genotoxic damage in somatic cells of underground coal miners. Chromosomal and genotoxic damage is an important step in carcinogenesis and the development of many other diseases. Our findings provide valuable insights into the effects of coal dust exposure on chromosomal integrity and genetic stability.

Conclusion

Our pilot study suggests that occupational exposure to coal induces chromosomal damage in underground coal miners, highlighting the importance of validating these findings with a larger sample size. Our results highlight the need to implement prevention and protection measures, as well as educational programs for underground coal miners. Characterizing and estimating exposure risks are extremely important for the safety of people exposed occupationally and environmentally to coal and its derivatives.
Level of client satisfaction among family planning service users in semi-pastoralist areas of Southeast Ethiopia: a mixed-methods study
Authors: Eshetu Hana , Tesfaye Dawit Jember , Fantahun Selam , Birhanu Bezawit , Deffecho Daniel Dere , Teshager Shitalem Tadesse , Meka Beka Teressa , Gufue Zenawi Hagos
Published: July 2024

Background

Client satisfaction with family planning services is a crucial metric for gauging healthcare providers' performance. There is a dearth of local data that explores the factors that influence clients' satisfaction with family planning services in semi-pastoral areas using a mixed-methods approach. This study aimed to assess the level of client satisfaction and its associated factors among family planning service users in six public health centers in Southeast Ethiopia.

Methods

A multi-centered, concurrent, mixed-method survey using quantitative and qualitative methods was conducted in six public health centers in Southeast Ethiopia from March 15 to April 16, 2022. Four hundred nineteen systematically selected family planning method users and their respective six family planning service providers were approached using a purposive sampling technique. A multivariable binary logistic regression model was used to identify the independent factors associated with clients' satisfaction with family planning services.

Results

Four hundred fourteen study participants were finally approached, and client satisfaction with family planning services in those centers was 57.5% with a 95% CI of 52.71%–62.71%. Being in the age group of 25–34 years (AOR = 1.99; 95% CI 1.2, 3.29), married (AOR = 2.41; 95% CI 1.13, 5.15), waiting less than 30 min (AOR = 1.74; 95% CI 1.11, 2.72), and receiving the family planning method they want (AOR = 2.35; 95% CI 1.16, 4.76) were positively associated with client satisfaction. Updating the provider's skills and knowledge, keeping clients' method choices, and leaving free decisions also increased client satisfaction.

Conclusions

In this study, client satisfaction with family planning services remains low. Users' age, marital status, waiting time, and wish to receive the method they want were positively associated with client satisfaction.
Hem1 inborn errors of immunity: waving goodbye to coordinated immunity in mice and humans
Authors: Christodoulou Alexandra , Tsai Julia Y. , Suwankitwat Nutthakarn , Anderson Andreas , Iritani Brian M.
Published: July 2024

Inborn errors of immunity (IEI) are a group of diseases in humans that typically present as increased susceptibility to infections, autoimmunity, hyperinflammation, allergy, and in some cases malignancy. Among newly identified genes linked to IEIs include 3 independent reports of 9 individuals from 7 independent kindreds with severe primary immunodeficiency disease (PID) and autoimmunity due to loss-of-function mutations in the NCKAP1L gene encoding Hematopoietic protein 1 (HEM1). HEM1 is a hematopoietic cell specific component of the WASp family verprolin homologous (WAVE) regulatory complex (WRC), which acts downstream of multiple immune receptors to stimulate actin nucleation and polymerization of filamentous actin (F-actin). The polymerization and branching of F-actin is critical for creating force-generating cytoskeletal structures which drive most active cellular processes including migration, adhesion, immune synapse formation, and phagocytosis. Branched actin networks at the cell cortex have also been implicated in acting as a barrier to regulate inappropriate vesicle (e.g. cytokine) secretion and spontaneous antigen receptor crosslinking. Given the importance of the actin cytoskeleton in most or all hematopoietic cells, it is not surprising that HEM1 deficient children present with a complex clinical picture that involves overlapping features of immunodeficiency and autoimmunity. In this review, we will provide an overview of what is known about the molecular and cellular functions of HEM1 and the WRC in immune and other cells. We will describe the common clinicopathological features and immunophenotypes of HEM1 deficiency in humans and provide detailed comparative descriptions of what has been learned about Hem1 disruption using constitutive and immune cell-specific mouse knockout models. Finally, we discuss future perspectives and important areas for investigation regarding HEM1 and the WRC.