bluuebunny/crossref_metadata_2025 huggingface dataset:
Black hole complementarity from microstate models: a study of information replication and the encoding in the black hole interior
Authors: Kibe Tanay , Mondkar Sukrut , Mukhopadhyay Ayan , Swain Hareram
Published: October 2023

Abstract

We study how the black hole complementarity principle can emerge from quantum gravitational dynamics within a local semiclassical approximation. Further developing and then simplifying a microstate model based on the fragmentation instability of a near-extremal black hole, we find that the key to the replication (but not cloning) of infalling information is the decoupling of various degrees of freedom. The infalling matter decouples from the interior retaining a residual time-dependent quantum state in the hair which encodes the initial state of the matter non-isometrically. The non-linear ringdown of the interior after energy absorption and decoupling also encodes the initial state, and transfers the information to Hawking radiation. During the Hawking evaporation process, the fragmented throats decouple from each other and the hair decouples from the throats. We find that the hair mirrors infalling information after the decoupling time which scales with the logarithm of the entropy (at the time of infall) when the average mass per fragmented throat (a proxy for the temperature) is held fixed. The decoding protocol for the mirrored information does not require knowledge of the interior, and only limited information from the Hawking radiation, as can be argued to be necessitated by the complementarity principle. We discuss the scope of the model to illuminate various aspects of information processing in a black hole.
Künstliche Intelligenz in der internistischen Versorgung
Authors: Eckstein Jens
Published: October 2023

Die Integration von Technologien der künstlichen Intelligenz (KI) hat das Potenzial, sowohl die Effizienz als auch die Qualität der medizinischen Versorgung zu verbessern. In verschiedenen Fachbereichen der Inneren Medizin haben KI-Anwendungen bereits ihren festen Platz, während sich die Anwendungen in anderen Bereichen noch in unterschiedlichen Phasen der Entwicklung befinden. Ein wichtiger zu beleuchtender Aspekt sind die Auswirkungen der KI auf die Interaktion zwischen Patienten und Gesundheitsfachpersonen. Ein weiterer Faktor ist die Nachvollziehbarkeit der Funktionsweise involvierter KI-basierter Algorithmen. Neben notwendigen vertrauensbildenden Maßnahmen ist eine Integrierbarkeit der Technologie in bestehende Systeme anzustreben, um eine entsprechende Akzeptanz und breite Verfügbarkeit zu erreichen und die Mitarbeiter:innen auf administrativer Ebene zu entlasten.
Die Bedeutung des humanen Mikrobioms für die psychische Gesundheit
Authors: Refisch Alexander , Walter Martin
Published: October 2023

Die Zusammensetzung des Mikrobioms ist bei vielen häufigen psychiatrischen Erkrankungen verändert. Präklinische Studien haben wichtige Mechanismen aufgedeckt, über die das Mikrobiom mit neuronalen Funktionen im bidirektionalen Austausch steht. Dysregulationen im komplexen Zusammenspiel von Mikrobiom, Immunsystem, Stress-Response und Energiehomöostase könnten insbesondere in der frühen Lebensphase für die Entwicklung psychiatrischer Symptome im späteren Leben prädisponieren. Obwohl bisher nur wenige klinische Studien vorliegen, haben der weitreichende Einfluss des Mikrobioms auf neuronale und psychische Funktionen sowie seine hohe Plastizität großes Interesse an seinem therapeutischen Potenzial bei häufigen psychiatrischen Störungen geweckt.
The effects of paranoia and dopamine on perception of cohesion and conspiracy: a pre-registered, double-blind, placebo-controlled experiment
Authors: Raihani N.J. , Kamboj S.K. , Peniket M.J. , Norman J. , Ozturk O.C. , Iskandar G. , Bell V.
Published: October 2023

Paranoia is a common symptom of psychotic disorders but is also present on a spectrum of severity in the general population. Although paranoia is associated with an increased tendency to perceive cohesion and conspiracy within groups, the mechanistic basis of this variation remains unclear. One potential avenue involves the brain’s dopaminergic system, which is known to be altered in psychosis. In this study, we used large-N online samples to establish the association between trait paranoia and perceptions of cohesion and conspiracy. We further evaluated the role of dopamine on perceptions of cohesion and conspiracy using a double-blind, placebo-controlled laboratory experiment where participants received levodopa or a placebo control. Our results were mixed: group perceptions and perceptions of cohesion were higher among more paranoid individuals but were not altered under dopamine administration. We outline the potential reasons for these discrepancies and the broader implications for understanding paranoia in terms of dopamine dysregulation.
Multiresidue method for the determination of critically and highly important classes of antibiotics and their metabolites in agricultural soils and sewage sludge
Authors: Mejías Carmen , Santos Juan Luis , Martín Julia , Aparicio Irene , Alonso Esteban
Published: October 2023

In this paper, a method is proposed for the determination of antibiotics classified by the World Health Organization as critically important (four macrolides and three quinolones) and highly important (one tetracycline, one diaminopyridine, and three sulfonamides) and eight of their metabolites. The method is based on ultrasound-assisted extraction, dispersive solid-phase extraction clean-up, and analytical determination by liquid chromatography–tandem mass spectrometry. Variables affecting each stage of the analytical method were thoroughly optimised. The method was validated for its application to sewage sludge from different treatment stages (non-treated sludge: primary and secondary sludge; and treated sludge: digested sludge and compost) and to agricultural soil. Limits of quantification were in the range of 0.03–7.50 ng g−1 dry weight (dw) for most of the compounds. Accuracy values were in the range of 70–102%. Precision was below 17%. The application of the method to real samples revealed that macrolides and fluoroquinolones were the antibiotic classes at the highest concentrations in all types of samples. The lowest concentrations of antibiotics were measured in compost (highest concentration: 27 ng g−1 dw, corresponding to norfloxacin) and soil samples (highest concentration: 93 ng g−1 dw, corresponding to a metabolite of clarithromycin). The proposed method is the first developed to date for the determination of multiclass antibiotics and their main metabolites in sludge from different treatment stages. The method can provide a useful tool for obtaining information about antibiotics in sewage sludge prior to its application to agricultural soils and in agricultural soils.

Graphical Abstract
Multiscale Coupling and the Maximum of $${\mathcal {P}}(\phi )_2$$ Models on the Torus
Authors: Barashkov Nikolay , Gunaratnam Trishen S. , Hofstetter Michael
Published: October 2023

We establish a coupling between the $${\mathcal {P}}(\phi )_2$$

P

(
ϕ
)

2

measure and the Gaussian free field on the two-dimensional unit torus at all spatial scales, quantified by probabilistic regularity estimates on the difference field. Our result includes the well-studied $$\phi ^4_2$$

ϕ
2
4

measure. The proof uses an exact correspondence between the Polchinski renormalisation group approach, which is used to define the coupling, and the Boué–Dupuis stochastic control representation for $${\mathcal {P}}(\phi )_2$$

P

(
ϕ
)

2

. More precisely, we show that the difference field is obtained from a specific minimiser of the variational problem. This allows to transfer regularity estimates for the small-scales of minimisers, obtained using discrete harmonic analysis tools, to the difference field.As an application of the coupling, we prove that the maximum of the $${\mathcal {P}}(\phi )_2$$

P

(
ϕ
)

2

field on the discretised torus with mesh-size $$\epsilon > 0$$

ϵ
>
0

converges in distribution to a randomly shifted Gumbel distribution as $$\epsilon \rightarrow 0$$

ϵ
→
0

.
Microbial Phytases: Properties and Applications in the Food Industry
Authors: Joudaki Hanane , Aria Negar , Moravej Roya , Rezaei Yazdi Mohamadreza , Emami-Karvani Zarrindokht , Hamblin Michael R.
Published: October 2023

Microbial phytases are enzymes that break down phytic acid, an anti-nutritional compound found in plant-based foods. These enzymes which are derived from bacteria and fungi have diverse properties and can function under different pH and temperature conditions. Their ability to convert phytic acid into inositol and inorganic phosphate makes them valuable in food processing. The application of microbial phytases in the food industry has several advantages. Firstly, adding them to animal feedstuff improves phosphorus availability, leading to improved nutrient utilization and growth in animals. This also reduces environmental pollution by phosphorus from animal waste. Secondly, microbial phytases enhance mineral bioavailability and nutrient assimilation in plant-based food products, counteracting the negative effects of phytic acid on human health. They can also improve the taste and functional properties of food and release bioactive compounds that have beneficial health effects. To effectively use microbial phytases in the food industry, factors like enzyme production, purification, and immobilization techniques are important. Genetic engineering and protein engineering have enabled the development of phytases with improved properties such as enhanced stability, substrate specificity, and resistance to degradation. This review provides an overview of the properties and function of phytases, the microbial strains that produce them, and their industrial applications, focusing on new approaches.
Assessing the future influence of the North Pacific trade wind precursors on ENSO in the CMIP6 HighResMIP multimodel ensemble
Authors: Pivotti Valentina , Anderson Bruce T.
Published: October 2023

The El Niño Southern Oscillation (ENSO), as one of the largest coupled climate modes, influences the livelihoods of millions of people and ecosystems survival. Thus, how ENSO is expected to behave under the influence of anthropogenic climate change is a substantial question to investigate. In this paper, we analyze future predictions of specific traits of ENSO, in combination with a subset of well-established precursors—the Trade Wind Charging and North Pacific Meridional Mode (TWC/NPMM). We study it across three sets of experiments from a protocol-driven ensemble from CMIP6—the High Resolution Model Intercomparison Project (HighResMIP). Namely, (1) experiments at constant 1950’s radiative forcings, and (2) experiments of present (1950–2014) and (3) future (2015–2050) climate with prescribed increasing radiative forcings. We first investigate the current and predicted spatial characteristics of ENSO events, by calculating area, amplitude and longitude of the Center of Heat Index (CHI). We see that TWC/NPMM-charged events are consistently stronger, in both the presence and absence of external forcings; however, as anthropogenic forcings increase, the area of all ENSO events increases. Since the TWC/NPMM-ENSO relationship has been shown to affect the oscillatory behavior of ENSO, we analyze ENSO frequency by calculating CHI-analogous indicators on the Continuous Wavelet Transform (CWT) of its signal. With this new methodology, we show that across the ensemble, ENSO oscillates at different frequencies, and its oscillatory behavior shows different degrees of stochasticity, over time and across models. However, we see no consistent indication of future trends in the oscillatory behavior of ENSO and the TWC/NPMM-ENSO relationship.
Permanent occlusion of the Eustachian tube: a retrospective study on reopening procedures
Authors: Sudhoff Holger
Published: October 2023

Purpose

This study retrospectively evaluated the efficacy and versatility of reopening procedures for the permanent occlusion of the cartilaginous Eustachian tube (POET) by analyzing four consecutive cases.

Methods

The study included all patients diagnosed with POET who suffered from Eustachian tube occlusion and glue ear. A combined approach of endoscopic transnasal/transoral laser surgery was utilized to reopen the POET. This was subsequently followed by balloon dilation (BET) and stenting for a duration of six weeks. In one distinct case, the Eustachian tube orifice was approached via a transtympanic method, where a balloon catheter was placed. The primary outcome measures targeted the success rate of reopening, which was quantified using audiological outcomes and Eustachian tube patency verified by a positive Valsalva maneuver.

Results

Four patients, with an age range of 14–62 years (mean age of 29.3 years), were subject to Eustachian tube reopening. The duration of follow-up varied between 10 and 24 months, averaging at 16.2 months. Notably, 75% of the surgically treated ears displayed no evidence of glue ear upon their last follow-up and showed restoration of Eustachian tube patency. The procedures were executed without any surgical complications. The causes for POET in these patients were heterogeneous: two were attributed to scarring post adenoidectomy, one to occlusion following orthognathic surgery and the remaining one due to prior radiotherapy treatment for squamous cell carcinoma located at the soft palate.

Discussion

Total occlusion of the cartilaginous Eustachian tube may be linked to persistent middle ear diseases. It is imperative to conduct nasopharyngeal endoscopy in these cases. The findings from this study suggest that the Eustachian tube reopening procedure is predominantly effective and safe for patients with POET stemming from a variety of pathologies. Future research should focus on exploring advanced stenting devices and necessitate longer follow-up periods for comprehensive understanding.
Spitting in the wind?—The challenges of RNA sequencing for biomarker discovery from saliva
Authors: Gosch Annica , Banemann Regine , Dørum Guro , Haas Cordula , Hadrys Thorsten , Haenggi Nadescha , Kulstein Galina , Neubauer Jacqueline , Courts Cornelius
Published: October 2023

Forensic trace contextualization, i.e., assessing information beyond who deposited a biological stain, has become an issue of great and steadily growing importance in forensic genetic casework and research. The human transcriptome encodes a wide variety of information and thus has received increasing interest for the identification of biomarkers for different aspects of forensic trace contextualization over the past years. Massively parallel sequencing of reverse-transcribed RNA (“RNA sequencing”) has emerged as the gold standard technology to characterize the transcriptome in its entirety and identify RNA markers showing significant expression differences not only between different forensically relevant body fluids but also within a single body fluid between forensically relevant conditions of interest. Here, we analyze the quality and composition of four RNA sequencing datasets (whole transcriptome as well as miRNA sequencing) from two different research projects (the RNAgE project and the TrACES project), aiming at identifying contextualizing forensic biomarker from the forensically relevant body fluid saliva. We describe and characterize challenges of RNA sequencing of saliva samples arising from the presence of oral bacteria, the heterogeneity of sample composition, and the confounding factor of degradation. Based on these observations, we formulate recommendations that might help to improve RNA biomarker discovery from the challenging but forensically relevant body fluid saliva.
eHealth tools to assess the neurological function for research, in absence of the neurologist – a systematic review, part I (software)
Authors: Ferreira Vasco Ribeiro , Metting Esther , Schauble Joshua , Seddighi Hamed , Beumeler Lise , Gallo Valentina
Published: October 2023

Background

Neurological disorders remain a worldwide concern due to their increasing prevalence and mortality, combined with the lack of available treatment, in most cases. Exploring protective and risk factors associated with the development of neurological disorders will allow for improving prevention strategies. However, ascertaining neurological outcomes in population-based studies can be both complex and costly. The application of eHealth tools in research may contribute to lowering the costs and increase accessibility. The aim of this systematic review is to map existing eHealth tools assessing neurological signs and/or symptoms for epidemiological research.

Methods

Four search engines (PubMed, Web of Science, Scopus & EBSCOHost) were used to retrieve articles on the development, validation, or implementation of eHealth tools to assess neurological signs and/or symptoms. The clinical and technical properties of the software tools were summarised. Due to high numbers, only software tools are presented here.

Findings

A total of 42 tools were retrieved. These captured signs and/or symptoms belonging to four neurological domains: cognitive function, motor function, cranial nerves, and gait and coordination. An additional fifth category of composite tools was added. Most of the tools were available in English and were developed for smartphone device, with the remaining tools being available as web-based platforms. Less than half of the captured tools were fully validated, and only approximately half were still active at the time of data collection.

Interpretation

The identified tools often presented limitations either due to language barriers or lack of proper validation. Maintenance and durability of most tools were low. The present mapping exercise offers a detailed guide for epidemiologists to identify the most appropriate eHealth tool for their research.

Funding

The current study was funded by a PhD position at the University of Groningen. No additional funding was acquired.
Subjective and objective responses to caloric stimulation help separate vestibular migraine from other vestibular disorders
Authors: Hannigan I. P. , Rosengren S. M. , Bharathy G. K. , Prasad M. , Welgampola M. S. , Watson S. R. D.
Published: October 2023

Background

Nystagmus generated during bithermal caloric test assesses the horizontal vestibulo-ocular-reflex. Any induced symptoms are considered unwanted side effects rather than diagnostic information.

Aim

We hypothesized that nystagmus slow-phase-velocity (SPV) and subjective symptoms during caloric testing would be higher in vestibular migraine (VM) patients compared with peripheral disorders such as Meniere’s disease (MD) and non-vestibular dizziness (NVD).

Methods

Consecutive patients (n = 1373, 60% female) referred for caloric testing were recruited. During caloric irrigations, patients scored their subjective sensations. We assessed objective-measures, subjective vertigo (SVS), subjective nausea (SNS), and test completion status.

Results

Nystagmus SPV for VM, MD (unaffected side), and NVD were 29 ± 12.8, 30 ± 15.4, and 28 ± 14.2 for warm irrigation and 24 ± 8.9, 22 ± 10.0, and 25 ± 12.8 for cold-irrigation. The mean SVS were 2.5 ± 1.1, 1.5 ± 1.33, and 1.5 ± 1.42 for warm irrigation and 2.2 ± 1.1, 1.1 ± 1.19, and 1.1 ± 1.16 for cold-irrigation. Age was significantly correlated with SVS and SNS, (p < 0.001) for both. The SVS and SNS were significantly higher in VM compared with non-VM groups (p < 0.001), and there was no difference in nystagmus SPV. VM patients SVS was significantly different to the SVS of migraineurs in the other diagnostic groups (p < 0.001). Testing was incomplete for 34.4% of VM and 3.2% of MD patients. To separate VM from MD, we computed a composite value representing the caloric data, with 83% sensitivity and 71% specificity. Application of machine learning to these metrics plus patient demographics yielded better separation (96% sensitivity and 85% specificity).

Conclusion

Perceptual differences between VM and non-VM patients during caloric stimulation indicate that subjective ratings during caloric testing are meaningful measures. Combining objective and subjective measures could provide optimal separation of VM from MD.
Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT
Authors: Ricci Costantino , Ambrosi Francesca , Franceschini Tania , Giunchi Francesca , Grillini Alessia , Franchini Eugenia , Grillini Marco , Schiavina Riccardo , Massari Francesco , Mollica Veronica , Tateo Valentina , Bianchi Federico Mineo , Bianchi Lorenzo , Droghetti Matteo , Maloberti Thais , Tallini Giovanni , Colecchia Maurizio , Acosta Andres Martin , Lobo João , Trpkov Kiril , Fiorentino Michelangelo , de Biase Dario
Published: October 2023

The 2022 WHO classification of urinary and male genital tumors introduced several novel kidney entities exhibiting eosinophilic/oncocytic features with specific mutational backgrounds. Thus, molecular techniques, such as next-generation sequencing (NGS), became more commonly used for their evaluation. We studied 12 low-grade oncocytic tumors (LOT) of the kidney (from 11 patients), identified in a cohort of 210 eosinophilic/oncocytic renal tumors, diagnosed in our institution between October 2019 and May 2023, which represented 5.7% (12/210) of all eosinophilic/oncocytic renal tumors during this period. We reviewed their clinicopathologic, histologic, and immunohistochemical features, as well as their mutational profiles. We also reviewed the literature on NGS-derived data of LOT, by selecting papers in which LOT diagnosis was rendered according to the criteria proposed initially. Median age was 65 years (mean: 63.5; range 43–79) and median tumor size was 2.0 cm (mean: 2.2; range: 0.9–3.1). All tumors were positive for PAX8, CK7, and GATA3, and negative or focally positive for CD117/KIT. We found the following gene mutations: MTOR ((6/11), 54.5%)), TSC1 ((2/11), 18.2%)), and 1 had both NOTCH1 and NOTCH4 ((1/11), 9.1%)). Wild-type status was found in 2/11 (18.2%) patients and one tumor was not analyzable. A review of 8 previous studies that included 79 LOTs revealed frequent mutations in the genes that regulate the mammalian target of rapamycin (mTOR) pathway: MTOR (32/79 (40.5%)), TSC1 (21/79 (26.6%)), and TSC2 (9/79 (11.4%)). Other mutated genes included PIK3CA, NF2, and PTEN, not typically known to affect the mTOR pathway, but potentially acting as upstream and downstream effectors. Our study shows that LOT is increasingly diagnosed in routine practice when applying the appropriate diagnostic criteria. We also confirm that the mTOR pathway is strongly implicated in the pathogenesis of this tumor mainly through MTOR, TCS1, and TSC2 mutations, but other genes could also be involved in the pathway activation, especially in LOTs without “canonical” mutations.
First investigation of blood parasites of bats in Burkina Faso detects Hepatocystis parasites and infections with diverse Trypanosoma spp.
Authors: Thiombiano Noel Gabiliga , Boungou Magloire , Chabi Bertrand Adéchègoun Mèschac , Oueda Adama , Werb Oskar , Schaer Juliane
Published: October 2023

Bats are hosts to a large diversity of eukaryotic protozoan blood parasites that comprise species of Trypanosoma and different haemosporidian parasite taxa and bats have played an important role in the evolutionary history of both parasite groups. However, bats in several geographical areas have not been investigated, including in Burkina Faso, where no information about malaria parasites and trypanosomes of bats exists to date.

In this study, we collected data on the prevalence and the phylogenetic relationships of protozoan blood parasites in nine different bat species in Burkina Faso. Hepatocystis parasites were detected in two species of epauletted fruit bats, and a relatively high diversity of trypanosome parasites was identified in five bat species. The phylogenetic analyses recovered the trypanosome parasites of the bat species Rhinolophus alcyone and Nycteris hispida as close relatives of T. livingstonei, the trypanosome infections in Scotophilus leucogaster as closely related to the species T. vespertilionis and the trypanosomes from Pipistrellus nanulus and Epomophorus gambianus might present the species T. dionisii. These findings of the first investigation in Burkina Faso present a first snapshot of the diversity of protozoan blood parasites in bats in this country.
Early investigations of the Permo-Carboniferous glaciation of South Africa
Authors: Pfaffl Fritz A. , Dullo Wolf-Christian
Published: October 2023

A.G. Bain (1797–1864) was probably the first to describe the deposits of the Permo-Carboniferous glaciation of South Africa in 1844, but still attributed their formation to a volcanic origin. It was not until P.C. Sutherland (1822–1908) in 1868 and 1870 that the series was recognised as a glacial formation. J. E. Dunn (1844–1937) named this deposit the Dwyka Series or Dwyka Conglomerate after the Dwyka River near Prince Albert in South Africa in 1886. This series contains scratched boulders and varved sediments, and the basement is characterised by rounded boulders and striated surfaces as evidence of glaciation.

Graphical abstract
Alleviation effects of epigallocatechin-3-gallate against acute kidney injury following severe burns
Authors: Xu Hongyan , Pang Yichao , Sun Wei , Luo Yi
Published: October 2023

Background

Burn patients often face a high risk of acute kidney injury (AKI) after severe burn injuries, meanwhile epigallocatechin-3-gallate (EGCG) has been proven to be effective in alleviating organ injury.

Methods

This study used the classical burn model in rats. Thirty model rats were randomly divided into a Burn group, a Burn + placebo group, a Burn + EGCG (50 mg/kg) group, and ten non-model rats as Sham group. The urinary excretion of the rats was subsequently monitored for a period of 48 h. After 48 h of different treatments, rat serum and kidneys were taken for the further verification. The efficacy of EGCG was assessed in pathological sections, biochemical indexes, and at the molecular level.

Results

Pathological sections were compared between the Burn group and Burn + placebo group. The rats in the Burn + EGCG group had less kidney damage. Moreover, the EGCG group maintained significantly elevated urine volumes, biochemical indexes manifested that EGCG could reduce serum creatinine (Cr) and neutrophil gelatinase-associated lipocalin (NGAL) level and inhibit the oxidation-related enzyme malondialdehyde (MDA) level, meanwhile the superoxide dismutase (SOD) level was increased. The molecular level showed that EGCG significantly reduced the mRNA expression levels of the inflammation-related molecules interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).

Conclusion

The research indicated that EGCG had an alleviating effect on kidney injury in severely burned rats, and its alleviating effects were related to improving kidney functions, alleviating oxidative stress, and inhibiting the expression of inflammatory factors.
From Kernel Methods to Neural Networks: A Unifying Variational Formulation
Authors: Unser Michael
Published: October 2023

The minimization of a data-fidelity term and an additive regularization functional gives rise to a powerful framework for supervised learning. In this paper, we present a unifying regularization functional that depends on an operator $$\textrm{L}$$
L
and on a generic Radon-domain norm. We establish the existence of a minimizer and give the parametric form of the solution(s) under very mild assumptions. When the norm is Hilbertian, the proposed formulation yields a solution that involves radial-basis functions and is compatible with the classical methods of machine learning. By contrast, for the total-variation norm, the solution takes the form of a two-layer neural network with an activation function that is determined by the regularization operator. In particular, we retrieve the popular ReLU networks by letting the operator be the Laplacian. We also characterize the solution for the intermediate regularization norms $$\Vert \cdot \Vert =\Vert \cdot \Vert _{L_p}$$

‖
·
‖

=

‖
·
‖

L
p

with $$p\in (1,2]$$

p
∈
(
1
,
2
]

. Our framework offers guarantees of universal approximation for a broad family of regularization operators or, equivalently, for a wide variety of shallow neural networks, including the cases (such as ReLU) where the activation function is increasing polynomially. It also explains the favorable role of bias and skip connections in neural architectures.
Digit Ratio (2D:4D; Right-Left 2D:4D) and Multiple Phenotypes for Same-Sex Attraction: The BBC Internet Study Revisited
Authors: Manning John T. , Fink Bernhard , Trivers Robert
Published: October 2023

Same-sex attraction may be linked to low prenatal androgen (in men) and high prenatal androgen (in women). Digit ratio (2D:4D) is thought to be a negative correlate of prenatal androgen and right-left 2D:4D (Dr-l) to reflect lateralized differences in sensitivity to prenatal androgen. Lower 2D:4D has been reported for lesbians compared to heterosexuals, but links to high 2D:4D in gay men are less clear. The largest study thus far (the BBC Internet study) found no significant difference between the 2D:4D of lesbians and heterosexual women but a higher 2D:4D in gay men compared to heterosexual men. Here we consider the possibility that low and high prenatal androgen is associated with same-sex attraction in men (n = 108,779) and women (n = 87,742), resulting in more than two phenotypes. We examined the associations between 2D:4D, Dr-l, and same-sex attraction scores in the BBC Internet study. In contrast to the earlier report, which considered sexual orientation in categories, there were positive linear associations in men (right and left 2D:4D, but not Dr-l) and negative linear associations in women (right 2D:4D and Dr-l, but not left 2D:4D). There were no curvilinear relationships for right and left 2D:4D. However, Dr-l showed a U-shaped association with same-sex attraction in men. Thus, (1) high prenatal androgen may be implicated in female homosexuality, while both low and high prenatal androgen may be implicated in male homosexuality, and (2) large side differences in sensitivity to androgen may be associated with elevated same-sex attraction in men.
Reinforcement learning with model-based feedforward inputs for robotic table tennis
Authors: Ma Hao , Büchler Dieter , Schölkopf Bernhard , Muehlebach Michael
Published: October 2023

We rethink the traditional reinforcement learning approach, which is based on optimizing over feedback policies, and propose a new framework that optimizes over feedforward inputs instead. This not only mitigates the risk of destabilizing the system during training but also reduces the bulk of the learning to a supervised learning task. As a result, efficient and well-understood supervised learning techniques can be applied and are tuned using a validation data set. The labels are generated with a variant of iterative learning control, which also includes prior knowledge about the underlying dynamics. Our framework is applied for intercepting and returning ping-pong balls that are played to a four-degrees-of-freedom robotic arm in real-world experiments. The robot arm is driven by pneumatic artificial muscles, which makes the control and learning tasks challenging. We highlight the potential of our framework by comparing it to a reinforcement learning approach that optimizes over feedback policies. We find that our framework achieves a higher success rate for the returns ($$100\%$$

100
%

vs. $$96\%$$

96
%

, on 107 consecutive trials, see https://youtu.be/kR9jowEH7PY) while requiring only about one tenth of the samples during training. We also find that our approach is able to deal with a variant of different incoming trajectories.
Temporal changes in boreal vegetation under 70 years of conservation
Authors: Maliniemi Tuija , Huusko Karoliina , Muurinen Lauralotta , Grytnes John-Arvid , Tukiainen Helena , Virtanen Risto , Alahuhta Janne
Published: October 2023

Biodiversity conservation through protected areas (PAs) is often based on the idea that biodiversity is relatively static. This assumption is increasingly being challenged as species and communities shift their distributions in response to changing environmental conditions. Empirical evidence on the performance of PAs over decades is still sparse or lacking from several environments, although it is needed to understand species dynamics, support modelling of PA performance, assist PA management and ultimately, to achieve global biodiversity conservation goals. In 2021, we resurveyed vegetation of five boreal habitat types (heath forests, paludified forests, sun-exposed sites, mires and eulittoral sites) in Rokua National Park in Finland, where one of the conservation targets is to preserve the flora characteristic of the area. The study sites were originally surveyed in 1945-49, just before the National Park was established. Study sites have also remained free from the disturbances (forest fires and reindeer grazing) typical of boreal regions. We show that the compositional similarity of plant communities between habitat types has increased over time and is associated with the increase of forest species in several habitat types and the loss of many habitat-specific species. Drivers of change were most often linked to ongoing succession (understory closure) and changes in moisture conditions. Our results suggest that without natural disturbance or appropriate management efforts, the original conservation targets may be compromised over the decades. Our study demonstrates that resurvey of historical vegetation data can be effectively used to estimate long-term PA performance, helping to fill in missing temporal evidence.
Elevational changes in canopy Collembola community composition are primarily driven by species turnover on Changbai Mountain, northeastern China
Authors: Wu Yunga , Xie Zhijing , Wan Zhuoma , Ji Qiao-Qiao , Yang Jingjing , Chen Ting-Wen , Wu Donghui , Scheu Stefan
Published: October 2023

Forest canopies harbor extraordinary biodiversity, with Collembola being one of the most abundant arthropod taxa. However, much of the research on canopy biodiversity has focused on tropical and subtropical regions, leaving a gap in our understanding of canopy communities in temperate and boreal forests. Studying canopy Collembola along elevational gradients can be particularly informative because several environmental factors change with elevation, and these changes may mirror those seen along latitudinal gradients. To better understand and conserve canopy Collembola diversity along elevational gradients, natural forests are of particular interest. In this study, we used canopy fogging to sample canopy Collembola at four elevation sites (800–1700 m a.s.l.) on Changbai Mountain, northeastern China, representing three natural forest types. We examined changes in species richness, abundance and composition of canopy Collembola, and partitioned beta diversity into nestedness and turnover to identify processes driving changes in community composition. We identified 53 morphospecies among 10,191 individuals, with Entomobryidae and Hypogastruridae being the dominant families. The highest abundance and species richness were observed at 1400 m and remained at similar levels at 1700 m, indicating an increasing pattern with elevation. Species turnover was the main driver of changes in community composition with elevation. Our results provide insights into the shift of canopy Collembola communities across an elevational gradient in temperate boreal forests.
Evaluation of the international Ki67 working group cut point recommendations for early breast cancer: comparison with 21-gene assay results in a large integrated health care system
Authors: Shim Veronica C. , Baker Robin J. , Jing Wen , Puentes Roisin , Agersborg Sally S. , Lee Thomas K. , GoreaI Wamda , Achacoso Ninah , Lee Catherine , Villasenor Marvella , Lin Amy , Kapali Malathy , Habel Laurel A.
Published: October 2023

Purpose

The International Ki67 Working Group (IKWG) has developed training for immunohistochemistry (IHC) scoring reproducibility and recommends cut points of ≤ 5% and ≥ 30% for prognosis in ER+, HER2−, stage I/II breast cancer. We examined scoring reproducibility following IKWG training and evaluated these cut points for selecting patients for further testing with the 21-gene Recurrence Score (RS) assay.

Methods

We included 307 women aged 50+ years with node-negative, ER+PR+HER2− breast cancer and with available RS results. Slides from the diagnostic biopsy were stained for Ki67 and scored using digital image analysis (IA). Two IHC pathologists underwent IKWG training and visually scored slides, blinded to each other and IA readings. Interobserver reproducibility was examined using intraclass correlation (ICC) and Kappa statistics.

Results

Depending on reader, 8.8–16.0% of our cohort had Ki67 ≤ 5% and 11.4–22.5% had scores ≥ 30%. The ICC for Ki67 scores by the two pathologists was 0.82 (95% CI 0.78–0.85); it was 0.79 (95% CI 0.74–0.83) for pathologist 1 and IA and 0.76 (95% CI 0.71–0.80) for pathologist 2 and IA. For Ki67 scores ≤ 5%, the percentages with RS < 26 were 92.6%, 91.8%, and 90.9% for pathologist 1, pathologist 2, and IA, respectively. For Ki67 scores ≥ 30%, the percentages with RS ≥ 26 were 41.5%, 51.4%, and 27.5%, respectively.

Conclusion

The IKWG’s Ki67 training resulted in moderate to strong reproducibility across readers but cut points had only moderate overlap with RS cut points, especially for Ki67 ≥ 30% and RS ≥ 26; thus, their clinical utility for a 21-gene assay testing pathway remains unclear.
A Meta-Analysis of the Impact of Entrepreneurs’ Gender on their Access to Bank Finance
Authors: Malmström Malin , Burkhard Barbara , Sirén Charlotta , Shepherd Dean , Wincent Joakim
Published: October 2023

This meta-analysis of 31 studies over 20 years advances our understanding of the gender gap in entrepreneurial bank finance. Findings from previous research on the relationship between entrepreneurs’ gender and bank financing are mixed, which suggests the need to pay particular attention to entrepreneurs’ social context. In this study, we develop a model of how social gender norms explain variation in women entrepreneurs’ (vis-à-vis men entrepreneurs’) access to bank finance. Specifically, we theorize how women’s formal (their nations’ political ideologies) and informal (women’s empowerment) social standing within their societies influence gender discrimination in entrepreneurial bank financing. Consistent with most previous studies, our baseline results show that women entrepreneurs’ business loan applications are rejected to a greater extent than men entrepreneurs’ loan applications. Women entrepreneurs also pay higher interest rates on loans than men entrepreneurs. Further, in societies dominated by a conservative (rather than a liberal) political ideology, the positive relationship between women entrepreneurs and loan interest rates is more positive. Interestingly, gender discrimination in loan rejection and interest rates is magnified in societies with greater women’s empowerment. Taking a social gender-norm perspective, our analysis establishes a gender gap in entrepreneurial bank finance, and we outline an agenda for further research.
Value of stent boost imaging in decision making after coronary stenting
Authors: Mansour Hossam M. , Mohamed Ahmed M. , Ibrahim Soliman G. , Ibrahim Ayman M. , Mohamed Ramadan G.
Published: October 2023

Background: Several studies reported the comparability of digital stent enhancement techniques (including stent boost imaging) in detecting suboptimal results of coronary stenting with Intra Vascular Ultrasound and optical coherence tomography. Aims: to assess results of stent deployment and determine the incidence of suboptimal results requiring changing final decision using stent boost imaging. Methods: This cross-sectional study included 120 patients eligible for PCI were recruited during a period of one year (January 2021 to 2022) using DES. Results: Suboptimal results were found in 38% of the PCI cases with stents (angiography guided). Importantly it was found that improper lesion preparation in our practice could not help improving stent optimization. Also, angiography guided PCI has significant incidence of suboptimal results. Digital stent enhancement techniques like stent boost have significant and important value in better decision making. After adjusting for age and sex, six factors were identified as independent predictors for final decision change (stent length, LAD/RCA affection, proximal segment affection, calcification, and optical coherence tomography. Conclusion: This study has confirmed the utility of stent boost for the optimization of PCI in daily practice. Stent Boost is a simple and costless technique that provides an accurate assessment of a deployed stent without extending the procedure time and without more risk. It appears to be useful for the immediate evaluation of stent expansion and optimization of PCI by additional post-dilatation, when appropriate. Future studies are needed to determine whether Stent Boost data will correlate with adverse long-term clinical outcomes in patients undergoing PCI.
β-Irradiation in the presence of 1,3-dialkylimidazolium ionic liquids causes covalent cellulose derivatization with simultaneous nitrogen incorporation
Authors: Jusner Paul , Sulaeva Irina , Schiehser Sonja , Potthast Karin , Tischer Alexander , Barbini Stefano , Potthast Antje , Rosenau Thomas
Published: October 2023

β-Irradiation (“e-beaming”) as well as swelling in ionic liquids, each process by itself, are common pretreatments in biorefinery scenarios. A combination of both, such as occurs with β-irradiation of biomass that was insufficiently washed and still contains traces of ionic liquids, causes covalent derivatization of the contained cellulose and incorporation of nitrogen. The nitrogen uptake occurred only in the presence of the ionic liquid and correlated linearly with both the irradiation dose and the concentration of the contained ionic liquid. The presence of other wood constituents during β-irradiation decreased nitrogen uptake, but did not prevent it. The derivatization of cellulose did not depend on the degree of crystallinity, but appeared to depend on the content of oxidized groups (carbonyl functionalities), also with a linear correlation. Future work must now clarify the mechanism of this reaction and the influence of other wood constituents, and address the possible potential of e-beaming in the presence of imidazolium ionic liquids for cellulose chemistry.
Real Property Transactions in the Network Society: Platform Real Estate, Housing Hactivism, and the Re-scaling of Public and Private Power
Authors: Roark M. L. , Fox O’Mahony L.
Published: October 2023

Technology is rapidly transforming the landscape of land ownership and housing transactions, creating new types of consumer risk and new regulatory challenges. As markets, legal systems, and housing consumers navigate the new opportunities and risks of “platform real estate” (or “PropTech”), the underlying land laws, policies, and practices that produce the material context and legal framework for real property transactions, and against which consumer risk and regulation must be understood, require “re-scaling.” In this article, we offer a theoretical framework for this re-scaling project, drawing on our earlier work to develop Resilient Property Theory (RPT) for analysing complex, large-scale property questions using methods that—in a departure from liberal property theories—pay attention to the public role of the state. Against a backdrop in which narratives of private property law defined real property transactions as “private realm” activities, while consumer law and policy provided the vehicle for state-backed regulation of specifically defined transactions based on a risk-based approach, this article brings the state back into view to reflect on new configurations of risk in consumer housing transactions. In the de-materialized realm of the “network society,” networks, platforms, and innovations are recalibrating housing transactions. In this data-driven world, land transactions are financialized, depersonalized, and increasingly remote from the materiality of land and the consumption of housing. As new capabilities in digital land transaction systems reach back into the underlying law of ownership, official (state), insider (global capital markets), and outsider (social movement activists) networks have evolved to leverage their relative positionality. This article uses techniques developed in RPT to examine the re-scaling of risk in real property and housing transactions through digital network technologies. We consider the implications of resilience needs in the network society in relation to the public sovereignty of the state, the private sovereignty of land ownership, and practices of resistance to public and private sovereignty through “housing hacktivism.” Finally, we argue that conceptions of consumer vulnerability and risk and embedded ideas about the relationships between private property law and consumer law and policy in real property transactions must evolve to take account of these effects.
Working from Home During Covid-19 Pandemic and Changes to Fertility Intentions Among Parents
Authors: Kurowska Anna , Matysiak Anna , Osiewalska Beata
Published: October 2023

The Covid-19 pandemic and related massive spread of home based work led to substantial changes in the conditions for combining work and childbearing. On the one hand, working from home helped parents to accommodate increased childcare needs during the pandemic. On the other hand, it led to acute experiences of blurred boundaries between work and family life during childcare and school closures. Therefore, the direction of the impact of working from home on fertility intentions during the pandemic is not unequivocal. In this paper, we investigate how working from home was related to change in fertility intentions of mothers and fathers during the pandemic and discuss the complex mechanisms behind these relationships. With the use of unique Familydemic Survey data from a representative sample of parents in Poland, we estimate multinomial logit regressions by gender and consider a set of potential moderators, including financial well-being, gender relations, and occupational characteristics. We find evidence for an overall negative relationship between home based work and fertility intentions for mothers, but we also uncover some positive moderating effects. In particular, we shed light on the unobvious moderating role of gendered division of unpaid labor from before the pandemic.