bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS VALUE AT RISK PORTOFOLIO SAHAM LQ45 DENGAN METODE SIMULASI MONTE CARLO CONTROL VARIATES
Authors: Widiyatari Westi , Sulistianingsih Evy , Andani Wirda
Published: October 2023

Value at Risk (VaR) with the Monte Carlo (MC) simulation is an estimate of the maximum loss over a given period of time and with a specific degree of confidence. MC VaR uses the Control Variates (CV) technique which is one of the reduction techniques in the MC method to improve the efficiency of VaR estimation. This study also aims to analyze the risk of the LQ45 indexed stock portofolio with Monte Carlo Control Variates (MCCV) VaR. In addition, this study compares MCCV VaR with standar MC VaR. The closing prices of the shares of PT Bank Negara Indonesia Tbk (BBNI) and PT Bank Central Asia Tbk (BBCA) were the source of the data for this study. The 95% confidence level is used for this study to estimate one-day MCCV VaR. The results obtained show that MCCV is able to reduce the variance of the estimate more quickly than the standar MC VaR. Thus, MCCV VaR is more efficient than the standard MC VaR.
Difabel Merajut Asa Berdaya: Pendekatan Strategis Pemberdayaan Difabel oleh Yayasan Pensil Waja Banua Kota Banjarmasin
Authors: Yemima Yuni , Hamid Ismar
Published: October 2023

Yayasan Pensil Waja Banua merupakan sebuah lembaga yang menjalankan program pemberdayaan bagi kaum difabel di Kota Banjarmasin. Penelitian ini bertujuan untuk menganalisis pendekatan strategis yang diterapkan oleh Yayasan Pensil Waja Banua, serta keberhasilan-keberhasilan yang dicapai. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Teknik pengumpulan data menggunakan observasi partisipan, wawancara mendalam dan dokumentasi. Hasil penelitian menunjukan bahwa difabel yang menjadi sasaran program Yayasan Pensil Waja Banua belum mencapai tingkat berdaya yang sepenuhnya, atau masih berada pada proses merajut asa berdaya. Pendekatan strategis yang diterapkan oleh Yayasan Pensil Waja Banua telah mencakup lingkup enabling, empowering dan protecting. Wujud enabling terlihat pada: penggalian dan motivasi pengembangan potensi difabel; serta, program sahabat difabel, program video layanan dan pendidikan kesehatan seksual dan reproduksi (kespro) bagi anak difabel. Sedangkan wujud empowering terlihat pada program pelatihan bahasa isyarat dan pelatihan kewirausahaan. Adapun protecting diwujudkan melalui pendampingan pada difabel. Program-program pemberdayaan yang dilakukan telah mampu berkontribusi pada peningkatan kepercayaan diri dan keterampilan para difabel yang diperlukan untuk mengembangkan usaha, serta telah berimplikasi pada peningkatan pendapatan pada sebagian difabel yang diberdayakan. Namun masih terdapat kelemahan, yakni kurangnya program tindak lanjut dan monitoring pasca program pada difabel yang menjadi sasaran program. Dari segi penerapan prinsip pemberdayaan, Yayasan Pensil Waja Banua telah berupaya menerapkan prinsip kesetaraan dan partisipatif, namun dominasi fasilitator belum mampu dihindari sepenuhnya, terutama pada tahap perencanaan program. Sehingga difabel yang diberdayakan masih cenderung mendudukkan dirinya sebatas sasaran program, atau belum menunjukkan adanya inisiatif pada aspek-aspek tertentu yang merupakan fondasi dalam mewujudkan masyarakat berdaya.
Peran Dinas Sosial Dalam Mendampingi Masyarakat Pemerlu Pelayanan Kesejahteraan Sosial (PPKS) di Kota Banjarbaru
Authors: Makky Khairil , Rahman Hakim Arif , Asto Aji An’amta Dimas
Published: October 2023

Keberadaan anak jalanan sering di anggap sebagai suatu permasalahan, menjawab permasalahan ini Pemerintah Kota Banjarbaru menghadirkan kebijakan yang bernama Rumah Singgah Berkarakter program ini berfokus dalam menangani permasalah masyarakat yang berada pada kondisi Pemerlu Pelayanan Kesejahteraan Sosial (PPKS). Penelitian ini bertujuan untuk menemukan dan mendeskripsikan bentuk kegiatan Rumah Singgah Berkarakter, serta melihat peran Dinas Sosial dalam pendampingan PPKS (Pemerlu Pelayanan Kesejahteraan Sosial) Rumah Singgah Berkarakter di Banjarbaru. Penelitian ini adalah penelitian kualitatif, dengan teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Penelitian dilaksanakan di Rumah Singgah Berkarakter Kota Banjarbaru Kalimantan Selatan. Hasil penelitian menunjukan bahwa pendampingan sosial yang dilakukan oleh pekerja sosial sebagai berikut: (1) Pemungkinan atau Fasilitas yakni pemberian pengalaman pembelajaran hidup dan motivasi dari pekerja sosial di Rumah Singgah Berkarakter; (2) Penguatan yakni hasil Asasmen yang telah dilakukan oleh pekerja social apa yang di inginkan oleh PPKS maka pihak Rumah Singgah atau Dinas Sosial akan merekomendasikan mereka sesuai dengan apa yang di inginkan oleh Pemerlu Pelayanan Kesejahteraan Sosial PPKS; (3) Perlindungan yakni Dinas Sosial dan Rumah Singgah Berkarakter yang telah bekerja sama dengan instansi dan lembaga-lembaga untuk membatu menyelesaikan masalah terhadap PPKS; dan (4) Pendukung yakni instansi dan lembaga-lembaga yang turut ikut serta membantu PPKS yang menjadi sumber dana untuk mendukung agar permasalahan terhadap PPKS bisa di selesaikan. Penelitian ini menyimpulkan bahwa pendampingan sosial yang dilakukan kepada PPKS memberikan kesempatan untuk mengembangkan diri dan menjadi pribadi yang lebih baik.
Budaya Surung Sintak Sebagai Representasi Ketidakadilan Gender Dalam Keluarga
Authors: Maulidi Putra Muhammad , Pura Damaiyantai Varinia
Published: October 2023

Berkaitan dengan persoalan budaya surung sintak sejalan dengan berkembangnya kebiasaan perilaku masyarakat dalam bersosial yang sering kali kebablasan dari tujuan sebenarnya, berakibat pada identifikasi semua pekerjaan domestik rumah tangga menjadi tanggung jawab kaum perempuan. Penelitian ini bertujuan untuk mengetahui dan menganalisis bagaimana representasi budaya surung sintak dalam keluarga pada masyarakat Desa Sungai Dua Kecamatan Simpang Empat Kabupaten Tanah Bumbu. Jenis penelitian ini adalah deskriptif kualitatif dengan pendekatan Feminis. Informan penelitian dipilih dengan teknik pusposive sampling yang menghasilkan 10 informan. Teknik pengumpulan data dengan observasi, wawancara, dan dokumentasi. Teknik analisis data yaitu data reduction, display data, dan conclusion drawing. Hasil penelitian menunjukkan bahwa bentuk representasi budaya yang dikenal dengan surung sintak dalam keluarga di Desa Sungai Dua dicirikan oleh informan sebagai perlakuan laki-laki terhadap perempuan menikah yang menempatkan perempuan pada posisi yang lebih rendah daripada laki-laki. Sebagian masyarakat meyakini bahwa ternyata budaya surung sintak ini dapat dengan mudah diintegrasikan ke dalam rumah tangga karena tanggung jawab istri untuk melayani suaminya di rumah, serta tanggung jawab suami untuk menafkahi istri baik lahir maupun batin. Kesimpulan dari penelitian ini yaitu representasi budaya surung sintak dalam keluarga di Desa Sungai Dua digambarkan sebagai bentuk perlakuan laki-laki kepada perempuan yang merupakan suami dan istri dengan memposisikan perempuan dengan kedudukan yang lebih rendah daripada laki-laki yang dapat berdampak pada berbagai aspek kehidupan perempuan.
Tergerusnya Eko-Populisme Pengelolaan Lahan Gambut: Dampak Program Food Estate di Desa Bentuk Jaya Kabupaten Kapuas
Authors: Putri Devi Permata , Hamid Ismar
Published: October 2023

Peatlands with the characteristics that are prone to ecological damage, and the eco-populism of peatland management, are under threat due to the food estate program. The purpose of this study is to determine the impact of the food estate program on eco-populist values in peatland management in Bentuk Jaya Village Kapuas Regency. The research approach used is a qualitative approach with a case study type. Data were collected through participant observation, in-depth interviews and documentation. The results of this study show the ineffectiveness of the food estate program in Bentuk Jaya Village, especially in the agricultural sector. The results obtained have not been able to reach the target due to crop failure. The agricultural system that is applied not in accordance with the environmental conditions of peat is the root of the problem. In addition, the implementation of the food estate program ignores the eco-populist values of peatland management that exist in the community. Eco-populism is a perspective that pays more attention to the fate of people whose sources of life come from nature. A perspective that is contrary to the reality of the food estate program in Bentuk Jaya Village. The existence of the food estate program has an impact on the erosion of local wisdom of the community in farming, changes in the carrying capacity of the peat environment on people's lives, and the loss of community sources of life from endemic plants of peat ecosystems. Communities before the existence of food estate managed and utilized natural products in a way that adapted to peatland environmental conditions and was based on local wisdom. Now inversely, programs designed to prosper the community and oriented towards supporting the fulfillment of food needs nationally actually have a negative impact on the environment and society.
Pole Teppo Wara: Strategi Bertahan Hidup Masyarakat Nelayan Pancing Pada Musim Paceklik di Pulau Kerasian
Authors: Junaedi Muhammad Fadli , Hakim Arif Rahman
Published: October 2023

The fishing rod fishing community of Kerasian Island Village depends on the utilization of marine resources and is very dependent on the season, so that when the famine season arrives they find it difficult to find sources of income which has an impact on the family's economic condition. This study aims to find out and describe how the survival strategy of fishing rod communities in facing the famine season in Pulau Kerasian Village with an ethical theory approach to subcessence. The research method used is qualitative with a descriptive approach. The determination of informants in this study was by Purposieve Samling. The research informant was a family of fishing rod fishermen. The results showed: (1) minimizing family expenses is part of the survival strategy carried out by fishing families in Pulau Kerasian Village by implementing frugal living and replacing food of lower quality; (2) diversification of fishing workers during the famine season in Pulau Kerasian Village is mala'du or fishing not far from the plains, changing fishing areas, chart fishermen, boatbuilders, and the involvement of family members; (3) Good social relations are a solution for fishing families in Pulau Kerasian Village to survive when the famine season arrives by asking for help from their relatives, be it help from family, debt to neighbors, and assistance from the government. The study concluded that fishing rod fishermen in Pulau Kerasian Village have various strategies to survive in the face of famine seasons that occur every year.
Mengubah Sampah Menjadi Rezeki: Analisis Actors Dalam Pemberdayaan Masyarakat Pada Pengelolaan Sampah.
Authors: Sahrul  , Budhi Setia
Published: October 2023

In the ACTORS theory, there is an ACTORS framework consisting of Authority, Confidence and Competence, Trust, Opportunities, Responsibilities, and Support. This study aims to determine and describe the ACTORS and impacts in community empowerment through waste management at the Baiman Main Waste Bank, Alalak Utara Village, Banjarmasin City. This research uses qualitative research. The data collection techniques used in this research are observation, interviews and documentation. The results of research through the ACTORS framework show that the manager's authority in making decisions related to programs and activities in the waste bank is an authority that cannot be intervened by the Banjarmasin city government. Through trust that is well established between managers and customers, it provides opportunities for customers to participate in training and making recycled products. By participating in training and making recycled products, customers gain economic capacity. The opportunities provided by the Waste Bank through training in making recycled products foster an entrepreneurial spirit in the community. Support from the Banjarmasin City Government in providing transportation facilities to support waste transportation activities.  Based on the ACTORS analysis, there are no points of belief and responsibility in the empowerment activities and programs of the Banjarmasin City Baiman Main Waste Bank. The programs carried out by Baiman Main Waste Bank have an impact on the community including: the health and environmental impact of sorting activities, the impact of sorting activities on gender equality, economic impacts and business opportunities, impacts related to the 3R principle, through the reuse of waste.
Suka Korea: Peniruan Perilaku Ala Korea di Kalangan Mahasiswa FISIP ULM
Authors: Mardina Titin , Damaiyanti Varinia Pura
Published: October 2023

Korean popular culture or hallyu whose spread can influence students in accepting culture from outside. This study aims to find out the Korean cultural trends that students have followed and how the process of imitating the behavior of students who follow these trends. This study uses a qualitative research method with a phenomenological approach. Data collection techniques used are observation, interviews and documentation. The results of this study indicate that FISIP ULM students have known Korean popular culture trends since they were in elementary school until now through watching Korean dramas on television and getting to know Korean music/K-pop through YouTube. From Korean dramas and K-pop, students learn about other trends, such as Korean fashion, Korean specialties and the Korean language. Trends in Korean popular culture that have been followed by FISIP ULM students are Korean drama shows, Korean music/K-pop, Korean-style fashion, Korean specialties and Korean language. Then, from getting to know the trend of Korean popular culture, students are interested in imitating the behavior of actors and actresses in Korean dramas and also their K-pop idols. Trends that are imitated such as clothing styles that give a casual but relaxed look, more colorful and simple, minimalist make-up displays, and hairstyles that they like as well as trends in Korean food and Korean language that make them curious and interested in trying and learning it.
INTERAKSI METABOLISME MANUSIA-ALAM: ENVIRONMENTAL ETHIC MASYARAKAT ADAT JUHU DALAM PENGELOLAAN HUTAN
Authors: Aprilia Ribka , Hamid Ismar , Hidayah Sri
Published: October 2023

In the midst of the rise of the ruling anthropocentric disposition, there is still, a group of people who reject the disposition that symbolizes selfishness and lean more towards the disposition of ecocentrism. This study aims to find and describe the way people view and interpret their forests and discover values related to ecocentrism ethics. Data collection techniques used observation techniques, interviews and documentation, as well as focus group discussions and strengthened by secondary data from literature studies. This research is field research, with a qualitative approach. The research was carried out in Juhu Village, Batang Alai Timur District, Hulu Sungai Tengah Regency, South Kalimantan. The results showed that the people of Juhu Village have a very strong attachment to the forest where they live. Judging from various activities and activities in the form of rituals, there is always an element of respect for nature. Juhu society is very dependent on nature. A form of ecocentrism in the Juhu community, starting from local wisdom and daily activities that are considered ordinary even though they contain management values. Nowadays, people are starting to make movements to reject actions or decisions that could destroy the environment in which they live, by being more courageous to speak out. Juhu people no longer rely solely on local knowledge, they also use technology as a supporting tool. In the future, the Juhu community will be more courageous in voicing opinions and desires about sustainability values.
Faktor Pendorong Praktik Perkawinan Anak Di Desa Taman Baru, Kecamatan Sekotong
Authors: Dafani Sherly Kurnia , Komalasari Maya Atri , Awalia Hafizah
Published: October 2023

Child marriage is a marriage performed under the age permitted to marry. Although various regulations have been made, the number of child marriages each year has not decreased significantly. Related to this, the factors that underlie child marriage actors in carrying out child marriage practices can be a reference in answering this problem. This study aims to find out what are the factors that encourage youth to practice child marriage in Taman Baru Village, Sekotong District, West Lombok Regency. The research method used is qualitative with a phenomenological research design. The unit of analysis in this study is an individual who knows about the issue of child marriage. The subject collection technique used was purposive sampling. Data collection techniques used are observation, interviews and documentation. The data analysis technique used is condensation, data presentation, and drawing conclusions. In testing the validity of the data, this study used a source triangulation technique. The results of the study show that the factors that encourage youth to practice child marriage consist of internal and external factors. Internal factors include because of their own desires; External factors include parental factors, partner factors, economic factors, traditional factors, friendship environmental factors, religious factors, and internet factors.
Study of Equipment to Measure Quantities Related to Electricity in a Three-Phase Engine
Authors: Carvalho Almeida Emanuella , Gonçalves Pereira Gabriel , Reis Wesley Mota dos , Caparrós da Silva Jadiel
Published: October 2023

This study examines the WaveBook/516E device for measuring electrical energy in three-phase engines. Accurate measurement and analysis of electrical energy is critical to engine performance and efficiency. However, existing devices often lack comprehensive data analysis capabilities, which hinders researchers' understanding of engine characteristics and electrical quantities. The study focuses on the WaveBook/516E, which features data storage and customizable analysis options. The methodology involves a theoretical review, including references, data from engines, obtained using the device's standard configuration and flexible settings, underwent detailed statistical analysis. Results demonstrated consistent data for engines under different conditions, validating the device's potential for precise statistical analysis. The WaveBook/516E's data storage and customization options make it a valuable tool for research on electrical energy in three-phase engines, allowing researchers to explore various scenarios. This research helps to improve the understanding of engine behavior and promote efficient engine control practices. The device's ability to change input patterns expands its applicability to broader research in electrical energy measurement and analysis. Overall, the WaveBook/516E expands the capabilities of researchers by facilitating in-depth studies and sound engine control practices.
Aprendizado de Máquina Aplicado a Avaliação da Qualidade de Frutos
Authors: Barros Alves Junior Armano , Gramacho da Silva Warley
Published: October 2023

O presente trabalho teve como objetivo explorar o uso de técnicas de visão computacional e aprendizado de máquina para a análise e classificação de frutas, com foco na qualidade e controle pós-colheita. Através da utilização de algoritmos de segmentação e extração de características, foi possível identificar atributos importantes das frutas, como cor, forma e textura, permitindo uma avaliação do fruto. A aplicação de redes neurais artificiais, como o MultiLayer Perceptron e Convolutional Neural Network, possibilitou a classificação automática das frutas com base em suas características físicas, o que facilita a detecção de defeitos. Os resultados obtidos demonstraram o potencial dessas técnicas para a automação do processo de seleção e classificação de frutas, contribuindo para a melhoria da eficiência e qualidade da produção na seleção de frutos.
Financial Integration and International Dynamics: The Role of Volatility Shocks
Authors: Tang Aidi
Published: October 2023

This study investigates the impact of financial integration on international dynamics from the perspective of volatility shocks. To achieve this, I employ an IRBC model with time-varying volatilities, recursive preferences, and a global bank. The model demonstrates that volatility shocks trigger precautionary saving incentives, but the specific effects vary based on the type of shock. In the presence of productivity volatilities, countries with a higher level of financial integration exhibit greater divergence in their business cycles, while financial integration tends to result in more synchronized business cycles in the face of financial volatilities. Disregarding volatility shocks would underestimate the impact of financial integration on the comovement of business cycles across countries. Furthermore, welfare analysis also indicates that financial markets play a crucial role in enhancing social welfare, regardless of the type of volatility.
Analysis of Holding Force Acting on Anchored Vessels
Authors: MIN Seungsik , OH Kyungwon
Published: October 2023

In this paper, a mathematical and physical interpretation of the length and the angle of the catenary curve made by the anchor chains was implemented, and the safety of an anchored vessel was reviewed. So far, holding force has been calculated approximately when the angle of the catenary curve of the anchor chain to the seafloor is 0°. In this study, the holding force equation was strictly derived for the case of anchor dragging. In addition, the equations for the angle and length of the catenary curve were mathematically derived when the anchor dragging occurs. The holding force equation derived in this paper are expected to help provide guidelines in vessel design or increase the safety of anchoring.
Finite Difference Scheme and Finite Volume Scheme for Fractional Laplacian Operator and Some Applications
Authors: Wang Junjie , Yuan Shoucheng , Liu Xiao
Published: October 2023

In the paper, we develop some numerical schemes including finite difference scheme and finite volume scheme for the fractional Laplacian operator, and apply the resulted numerical schemes

to solve some fractional diffusion equations.

First, the fractional Laplacian operator can be characterized as the weak singular integral by a integral operator with zero boundary

condition.

Second, because of the solution of fractional diffusion equation is usually singular near the boundary, we apply finite difference scheme to discrete fractional Laplacian operator and fractional diffusion equation by fractional interpolation function.

Moreover, it is find that the differential matrix of the above scheme is symmetric matrix, and strictly row-wise diagonally dominant in special fractional interpolation function.

Third, we show finite volume scheme to discrete fractional diffusion equation by fractional interpolation function,

and analyze the properties of differential matrix.

Finally, the numerical experiments are given, and verify the correctness of theoretical results and the efficiency of the schemes.
“You’re Just Fat”: A 36 cm Cyst Causing an Ovarian Torsion in a Twenty-Year-Old Woman After Presenting Symptoms of Concern to her Doctor for Years—A Case Report
Authors: Udabor Anita , Becker Chase Beverley , Becker Jan
Published: October 2023

Background. Ovarian cysts are common in premenopausal women but can present with vague, non-specific symptoms, making discovery more challenging. Most are benign and resolve spontaneously; however, they can present, as in this case, as ovarian torsions, which is a gynecological emergency. Case presentation. A twenty-year-old female had presented over 3–4 times per year for the last 6 years to her primary doctor citing intermittent abdominal pain, irregular menstruation, dyspnea, and an enlarging abdomen circumference. The doctor stated, she was “just fat” and could, benefit from a “special camp to lose weight”, so she stopped mentioning her concerns. Upon presenting to the emergency department with acute onset abdominal pain, a computed tomography scan showed a large cyst lesion filling the abdominal and pelvic cavity. Its origin appeared to be from the left adnexa. Surgery was performed, and an acute ovarian torsion caused by a 36 cm craniocaudal left ovarian cyst was found and removed along with the left fallopian tube and 16 L of fluid. Conclusions. The value of respecting the “third presentation” rule indicates to health care providers that any patient who presents with any /or other symptoms or complaint needs to be thoroughly investigated. In this case the patient presented recurring pelvic/abdominal concerns, irregular menstruation, which warranted further investigation to safeguard fertility and prevent errors of omission. It is important to consider the differentials and be aware of vague symptoms that may lead to early recognition and effective management to prevent adverse consequences, complications, or even death.
Testing a Psychological Tool to Enhance Hope in People With Stroke; Qualitative Study
Authors: Soundy Andrew , Forkner Abby , Bresloff Arielle , Palser Holly , Bamford Tristan , Reed Alexander , Chan Chun
Published: October 2023

IntroductionHope is an essential concept for rehabilitation of people with stroke. The current study extended research on the model of emotions, adaptation, and hope (MEAH) by extending it according to a previously established framework of hope.MethodsAn interpretive hermeneutic phenomenological study was conducted. People with stroke living in the community of the West Midlands were included. Physiotherapy students received training as part of a research placement to deliver a single intervention session using an extended version of the MEAH. Content analysis of the responses to the MEAH were taken and a process evaluation was undertaken in the form of a semi-structured interview after the intervention.ResultsSeventeen individuals (70.1±12.2 years) with stroke were included. Results considered the responses to the MEAH as a therapeutic driver and a process evaluation from people with stroke that undertook the intervention. Important scoring differences were noted for those who could and those who were not able to set goals. The MEAH tool appeared to be one way to help develop goals for people with stroke in a personalised way, however the value of the tool was identified by those who did not set a goal. Positive experiences of the intervention were reported across all people with stroke.DiscussionThe MEAH tool may be one way to support stroke rehabilitation and enhance the therapeutic encounter between physiotherapists and people with stroke.
A Review of Demand-side Resources in Active Distribution Systems: Communication protocols, Smart metering, Control, Automation, and Optimization
Authors: Ratshitanga Mukovhe , Orumwense Efe Francis , Krishnamurthy Senthil , Melamu Moteane
Published: October 2023

Power systems have been going through a barrage of transformations due to the recent developments in the field, such as deregulation and restructuring of the electric power supply chain, the proliferation of distributed generation (DG), and advancements in information and communications technologies. These have significantly impacted the approach to the planning, design, and operation of active distribution networks or systems. Due to this constant change, the system has become more complex to plan, maintain, and control. In this paper, the benefits, and challenges of active distribution systems relative to traditional passive and active distribution systems are evaluated and investigated while the management and operational characteristics of demand-side resources in Active Distribution Systems (ADS) are studied. In a typical ADS, there exist several vulnerabilities and threats that eventually pose a challenge in the control and automation of substations. These vulnerabilities and threats are reviewed, and potential mitigation measures are suggested. Also in this paper, the communication technologies, and their implementation in terms of control and automation capabilities in active distribution networks are also studied. From this work, it is concluded that communication technologies play an integral role in the realization of a more active distribution networks and that the internet of energy (IoE) is a major player in ADS in the reduction of faults due to human error, fast responses, and improving the stability of power supply. Cyber threats are also and will still be a continuous challenge in smart metering technologies and in substation automation systems (SAS) which will require frequent evaluation and mitigation measures so as not to prevent the power supply system from collapsing.
A Cancer-Specific Monoclonal Antibody against Podocalyxin Exerted Antitumor Activities in Pancreatic Cancer Xenografts
Authors: Suzuki Hiroyuki , Ohishi Tomokazu , Tanaka Tomohiro , Kaneko Mika K. , Kato Yukinari
Published: October 2023

Podocalyxin (PODXL) overexpression is associated with poor clinical outcomes in various tumors. PODXL is involved in tumor malignant progression through the promotion of invasiveness and metastasis. Therefore, PODXL has been considered as a promising target of monoclonal antibody (mAb)-based therapy. However, PODXL also plays an essential role in normal cells such as vascular and lymphatic endothelial cells.Therefore, cancer-specificity or selectivity is required for the reduction of adverse effects on normal cells. Here, we developed an anti-PODXL cancer-specific mAb (CasMab), PcMab-6 (IgG1, kappa), by immunizing mice with soluble PODXL ectodomain derived from a glioblastoma LN229 cell.PcMab-6 reacted with the PODXL-positive LN229 cells, but not with PODXL-knockout LN229 cells in flow cytometry. Importantly, PcMab-6 recognized pancreatic ductal adenocarcinoma (PDAC) cell lines (MIA PaCa-2, Capan-2, and PK-45H), but did not react with normal lymphatic endothelial cells (LECs). In contrast, one of the non-CasMabs, PcMab-47 showed high reactivity to both the PDAC cell lines and LECs. Next, we engineered PcMab-6 into a mouse IgG2a type (PcMab-6-mG2a) and a humanized IgG1-type (humPcMab-6) mAbs, and further produced the core fucose-deficient types (PcMab-6-mG2a-f and humPcMab-6-f, respectively) to potentiate the antibody-dependent cellular cytotoxicity (ADCC). Both PcMab-6-mG2a-f and humPcMab-6-f exerted ADCC and complement-dependent cellular cytotoxicity in the presence of effector cells and complements, respectively. In the PDAC xenograft model, both PcMab-6-mG2a-f and humPcMab-6-f exhibited potent antitumor effects. These results indicated that humPcMab-6-f could apply to antibody-based therapy against PODXL-expressing pancreatic cancers.
Ammonium and Phosphonium Salts Containing Monoanionic Iron(II) Half-Sandwich Complexes [Fe(5-Cp*)X2] (X = Cl – I)
Authors: Zinke Julian , Bruhn Clemens , Siemeling Ulrich
Published: October 2023

Stable half-sandwich iron(II) dihalido complexes of the type [Fe(5-Cp’)X2] are extremely scarce, being limited to congeners containing the bulky C5H2-1,2,4-tBu3 ligand. We have extended this to homologues [Fe(5-Cp*)X2] (X = Cl – I) containing the particularly popular C5Me5 (Cp*) ligand. Corresponding ionic compounds ER4[Fe(5-Cp*)X2] are easily accessible from FeX2, MCp* (M = Li, K) and a suitable halide source R4EX (E = N, P) in THF. The new compounds NnPr4[Fe(5-Cp*)X2] (X = Cl, Br), NnPr4[Fe(5-Cp*)BrCl] and PPh4[Fe(5-Cp*)X2] (X = Cl, Br, I) have been structurally characterised by single-crystal X-ray diffraction. NnPr4[Fe(5-Cp*)Cl2] reacts readily with CO to afford [Fe(5-Cp*)Cl(CO)2], indicating the synthetic potential of ER4[Fe(5-Cp*)X2] in FeCp* half-sandwich chemistry.
Enhanced Monitoring and Decision Support in Pancreatic Cancer through Holistic Health Records and Advanced Data Processing: the iHELP Platform
Authors: Manias George , Azqueta-Alzúaz Ainhoa , Berenguer Mari Juan Ramon , Dalianis Athanasios , Griffiths Jake , Kalogerini Maritini , Kostopoulou Konstantina , Kouremenou Eleftheria , Kranas Pavlos , Kyriazakos Sofoklis , Lekka Danae , Melillo Fabio , Patiño-Martínez Marta , García-Perales Óscar , Pnevmatikakis Aristodemos , Spanos Spyros , Torrens Salvador Garcia , Wajid Usman , Kyriazis Dimosthenis
Published: October 2023

The healthcare domain is increasingly adopting IoT and Electronic Health Record (EHR) systems, generating vast volumes of healthcare data. This shift is driven by the growing need of delivering the right information to the right individuals, at the right time. The latter underscores the importance of adopting a comprehensive strategy for efficiently collecting, utilizing, and analyzing health-related data to not only enhance overall healthcare management but also for the provision of timely and personalized prevention strategies. The latter is of highest importance especially in scenarios where lack of effective treatments or poor survival rates (such in pancreatic cancer) renders typical healthcare strategies ineffective. In this article, we introduce an innovative and integrated platform that is specifically designed and developed for accessing, processing, and analyzing data in challenging healthcare scenarios, such as dealing with pancreatic cancer. This platform, called iHelp, combines multidisciplinary technologies and provides healthcare professionals reliable risk modelling, analysis, and prediction techniques so that individuals (at risk of developing pancreatic cancer) can be provided with timely, reliable, and personalized prevention and intervention measures. A key innovation in the iHelp platform is the standardized data management approach called Holistic Health Records (HHRs) that facilitate the capturing of all health determinants in a standardized and well-structured way for processing towards the provision of health risk detection and personalized healthcare decision support. In the development of iHelp platform, the HHRs are evaluated through different real-world healthcare datasets, including datasets coming from hospital systems, data from wearables, questionnaires, and mobile applications.
Me, Myself, and I: Neural Activity for Self versus Other Across Development
Authors: Zanchi Paola , Ledoux Jean-Baptiste , Fornari Eleonora , Denervaud Solange
Published: October 2023

Although adults and children differ in self-versus-other perception, the developmental perspective on this discriminative ability is missing. We compared neural activation of self-vs-others in 39 participants of 4 different age groups (4 yo. to adulthood). Two brain regions, the MCC and right postcentral gyrus, exhibited respectively non-linear and gradual gains in discriminative abilities for self-vs-others stimuli. These regions play critical roles in self-referential processing, empathy, and social cognition. Nine brain regions showed linear increase for others-vs-self stimuli. These regions are associated with multisensory processing, somatosensory skills, complex visual stimuli, self-awareness, empathy, theory of mind, and social recognition. Understanding the neural basis of self-vs-others discrimination during development can inform when and how social contexts support learning processes during childhood and adolescence.
Cobalt Catalyst Hysteresis Loop Simulations: The Impact of Nanoparticle Number and Nearest Neighbor Distance
Authors: Barmpatza Alexandra C. , Baklezos Anargyros T. , Vardiambasis Ioannis O. , Nikolopoulos Christos D.
Published: October 2023

This study investigates the magnetization of Cobalt (Co) nanoparticles with two different crystal structures: a centered cubic (fcc) and an hexagonal close packed (hcp), under the magnetic field of the Earth. For that reason, the hysteresis loops of the two material samples are exported and compared with the corresponding value by experimental procedure in the laboratory under the Earth’s magnetization. For both samples, the nanoparticle number variation and the nearest neighbor distance effect, in the Co hysteresis loop are investigated, structural information that is useful for the sample preparation. For the simulations the Finite Element Method (FEM) was used, while experiments are conducted using a measurement set-up based on fluxgate magnetometers. From the simulation, it is proven that, for both samples, the nanoparticle number effect does not change the hysteresis loop. In contrast, when the distance between the nanoparticles increases, the magnetization obtains smaller value. This study aims to build a novel, simple and economical measurement arrangement enabling in situ magnetic measurements for ferromagnetic nano-material characterization. As the need for continuous knowledge of the condition and the phase of ferromagnetic nanoparticles that is crucial in many applications, like catalytic processes, this work aims to introduce an alternative approach that will add another dimension to conventional chemical reaction engineering this of the magnetic state of the material resolved in time and space and to contribute in the field of the monitoring and the early fault diagnosis of nanoparticle materials.
Investigation of Hafnium Thin Films for Design of TES Microcalorimeters
Authors: Safonova Victoria Yu. , Gordeeva Anna V. , Blagodatkin Anton V. , Pimanov Dmitry A. , Yablokov Anton A. , Ermolaeva Olga L. , Pankratov Andrey L.
Published: October 2023

Hafnium is a metal with rare properties, such as a low superconducting transition temperature slightly above 100 mK, which makes it attractive for a lot of applications, especially for design and fabrication of microcalorimeters with high energy resolution. In this paper we describe the results of fabrication and experimental investigation of superconducting properties of hafnium thin films in a dilution refrigerator. The considered Hf films, whose thickness is in the range from 60 to 115 nm, are deposited on substrates by electron beam evaporation. The combinations with thin layers of normal metals to decrease the critical temperature of superconducting hafnium films by proximity effect, are also considered. The critical temperature of the studied films varies from 56 to 302 mK. Also, significant increase of the critical temperature of some films over time was observed and investigated.
SPECIAL ASPECTS OF NEUROMORPHOMETRY IN CONGENITAL HYPOTHYROIDISM (CLINICAL CASE)
Authors:   Siberian State Medical University, SAMOILOVA IULIIA G. , OLEYNIK OXANA A. ,   Siberian State Medical University, MATVEEVA MARIIA V. ,   Siberian State Medical University, TOLMACHEV IVAN V. ,   Siberian State Medical University, PODCHINENOVA DARIA V. ,   Siberian State Medical University, VACHADZE TAMARA D. ,   Siberian State Medical University, GALYUKOVA DARYA E. ,   Siberian State Medical University
Published: October 2023

Introduction. Based on the neonatal screening results the congenital hypothyroidism prevalence in the Russian Federation is 1 case per 3950 newborns. Moreover, thyroid hormones play an important role in glial myelination, neuronal migration, cortical layer formation, synaptogenesis and neurogenesis. Aim. To assess a patient with congenital hypothyroidism brain morphometric and neuropsychological status. Material and methods. This article describes a 24-year-old patient clinical case with congenital hypothyroidism, thyroid agenesis and cognitive decline associated with altered brain substance volume. Results and discussion. Many studies have shown that hypothyroidism is associated with cognitive deficits such as reduced attention, memory, psychomotor and executive functions. This clinical case confirms the known findings in the drug withdrawal background, with functions related to visual-constructive skills, fluency and memory being most affected by thyroid hormone deficiency. Some authors attribute these changes to decreased regional cerebral blood flow in brain regions associated with cognitive functions. A number of functional magnetic resonance imaging (MRI) studies have found the default mode network or reversible changes deactivation in the brain during working memory tasks. It is possible that functional changes occur when there is impaired the pathological process compensation, but in the congenital hypothyroidism changes, agenesis and increased duration case are possible. A study and brain morphometric revealed a decrease in subcortical structures, which some authors believe are responsible for neuroplasticity and cognitive function. Conclusion. In connection with this clinical example findings, attention should be drawn to the timely diagnosis importance as early as possible in the maternity home, euthyroidism maintenance, and hormonal status monitoring with correction also in adulthood, taking into account the possible effect on changes in brain structures and neuropsychological disorders development.
POLYMOrPHISMS OF THE ANTIOXIDANT SYSTEM ENZYMES SOD2 (C47T, rS4880) AND CAT (G262A, rS1001179) IN THE PATHOGENESIS OF CHrONIC HEPATITIS C
Authors:   Rybno-Slobodskaya Central Regional Hospital, Russia, Rybnaya Sloboda district, GINYATULLIN RINAT R. , KRAVCHENKO IRINA E. ,   Kazan State Medical University, GALEEVA NELLI V. ,   Kazan State Medical University, GIRFANUTDINOVA ENZHE R. ,   Kazan State Medical University
Published: October 2023

Introduction. An important component in the pathogenesis of chronic hepatitis C is the imbalance in oxidant and antioxidant systems. It is known that mutations in genes of antioxidant enzymes can lead to changes in antioxidant potential. Aim. To determine correlations of polymorphic variants of SOD2 (C47T, rs4880), CAT (G262A, rs1001179) superoxide dismutase and catalase genes with antioxidant system activity and features of clinical course of chronic hepatitis C. Material and Methods. The study of single nucleotide variants of genes of antioxidant enzymes of superoxide dismutase SOD2 (C47T) and catalase CAT (G262A) was undertaken in 90 patients with chronic hepatitis C and 64 healthy controls. Genomic deoxyribonucleic acid from the epithelium of the inner surface of the cheek using ‘SNP-screen ‘ diagnostic reagents was analysed. The levels of superoxide dismutase, catalase, alanine aminotransferase enzymes and degree of liver fibrosis were determined in the group of chronic hepatitis C patients. Correlations between investigated indexes were studied. Results and discussion. The distribution of alleles and genotypes of single nucleotide variants of catalase CAT (G262A) and superoxide dismutase SOD2 (C47T) genes among healthy subjects and chronic hepatitis C patients (p>0,05) had no significant difference (p>0,05), which testified to absence of influence of the studied gene variants on the risk of hepatitis C virus infection. We revealed statistically significant correlation of single-nucleotide variants of SOD2 (C47T) and CAT (G262A) genes with the development of chronic hepatitis C. Patients having G allele (genotypes GG and GA) of CAT (G262A) single nucleotide variants had low level of catalase enzyme, high level of alanine aminotransferase and high degree of F3-F4 fibrosis (correlation coefficient = -0,88*, p˂0,01). In patients with CC genotype SOD2 (C47T) a strong correlation with serum superoxide dismutase activity, severity of cytolysis syndrome (increased alanine aminotransferase) and degree of liver fibrosis (correlation coefficient = +0,70; p˂0,01) was established. Conclusion. In infection with hepatitis C virus polymorphic variants of SOD2 (C47T) and CAT (G262A) antioxidant system enzyme genes are the risk factors of hepatitis C progression, influencing catalase and superoxide dismutase enzyme activity, cytolysis syndrome development, determining liver fibrosis formation.
ECHOCARDIOGRAPHIC RESEARCH INDICATORS IN PATIENTS WITH BRONCHIAL ASTHMA AND HYPERTENSION DISEASE
Authors:   Perm State Medical University, MISHLANOV VITALIY Ju. , KOSHURNIKOVA EKATERINA P. ,   Perm State Medical University, ERGASHEVA UMIDA P. ,   National medical research center of cardiology, Russia
Published: October 2023

Introduction. The presence of comorbidities in patients with bronchial asthma can increase the frequency of attacks, lead to more severe symptoms during exacerbations, and reduce the quality of life of patients. Aim. The purpose is the evaluation of morphological and functional changes in the heart of patients with a comorbidity of bronchial asthma with the hypertension disease. Material and methods. The study included 55 patients, 4 groups were formed. The main group included 19 people with a combination of bronchial asthma with the hypertension disease. Primary comparison group was 20 people with bronchial asthma. The second comparison group consisted of 16 people with hypertension. The control group consisted of 25 healthy people. Echocardiographic parameters were studied and compared with the clinical and functional picture of the disease. The analysis of the results was performed by using methods of descriptive statistics. The correlation analysis was performed with considering the Spearman’s rank correlation coefficient. Results and discussion. In the analysis of the heart morphological and functional characteristics of patients with bronchial asthma and hypertension disease in comparison with the control groups there was an increase in the left atrium dimension and volume, right ventricular wall thickness, right ventricular outflow tract at proximal, a decrease in stroke volume and end- systolic volume with negligible changes of the ejection fraction, a decrease in the thickness of the posterior wall of the left ventricle and the interventricular septum. Conclusion. This article distinguishes the characteristics of progression of the disease, as well as suggests mechanisms of pathogenetic interaction in comorbidity of hypertension disease and bronchial asthma by assessing the main parameters of echocardiography. This method is used for the earliest detection of structural and functional changes. In patients with bronchial asthma and hypertension was pronounced morphological changes in the right parts of the heart and functional changes in the pulmonary circulation in comparison in patients with isolated disease. However, because of decrease in diastolic pressure in left parts of the heart and redistribution blood volume on the right side of the heart in the left parts of the heart are less susceptible to remodeling.
pengembangan Video Tutorial Make Up Flawless Pada Modifikasi Tata Rias Pengantin Sunda Putri
Authors: Shafira  , Sri Irtawidjajanti
Published: October 2023

Abstract

The development of this video tutorial was carried out to provide benefits and explanations to students and the public regarding the development of facial make-up for traditional Sundanese female brides, becoming modified Sundanese female brides which are currently trending, namely Flawless Make-up, flawless make-up which has characteristics such as natural make-up with use colors that are still soft natural, that is, you still look like you are wearing make up but with neater and glowing results, for example using soft pink and soft peach colors. The aim of this research is to produce a Video Tutorial for Flawless Make Up on Modifying Sundanese Women's Bridal Makeup that is suitable for production. This research method uses the ADDIE R&D research model which is used to produce certain products and test the effectiveness of the video. The process in this video consists of pre-production planning, production, post-production, research process, data processing and research results. The results of making this video tutorial meet the validation criteria obtained by material and professional experts, namely 81% and by media experts, 100%. It can be concluded that this video is very suitable to be used as a learning medium for students in the Indonesian Bridal course in the Middle Part of the Cosmetology Study Program.