bluuebunny/crossref_metadata_2025 huggingface dataset:
Innovative non-pump gravity driving microfluid culture chip enhance mouse blastocyst formation
Authors: Hsieh Yao-Yuan , Huang Tsung-Tao , Kao Tzu-Chieh , Chang Chi-Chen , Hsieh Jen-Hsiang
Published: July 2024

Objectives: Various microfluidic technologies are currently used in ART. Herein we designed an innovative non-pump microfluidic culture platform to enhance the embryo culture in-vitro. We try to elucidate its feasibility and differences compared to traditional micro-drip culture systems.
Materials and methods: We innovated a microfluidic chips with series procedures, including fabrication of an SU-8 master mould; casting of polydimethylsiloxane (PDMS) on mould; and integrating microfluidic device. All mouse embryos were divided: (1) traditional static drops; (2) microfluid static controls; (3) dynamic microfluid chip. We used the gravity plateform with tilt angle 15 degree to drive the culture medium through the whole microchannels. The cytotoxicity surveys of chip materials were performed with MTT assay. The embryo developments in each groups was compared.
Results: The MTT surveys appeared the non-toxicity of PDMS chip materials. The percentages of 2 cell embryos reaching the stage of 4-8 cells, morula, and early blastocyst were comparable between both groups. In contrast, higher percentages of expanding blastocys and hatching blastocyst were observed in microfluid chip group. The percentages of 4-8 cells/morula/early/expanding/hatching blastocyst in each groups were 92.4/85.4/71.2/52.5/45.7%; 93.5/84.5/69.2/52.2/45.7%; and 93.8/86.5/74.5/67.2/60.4%, respectively.
Conclusions: Combined microfluid and non-pump tilting culture system results in the dynamic stimulation of the embryos and automatic waste swept, which could not provided by traditional culture system. The tilting gravity instead of the motor driving system improves the convenience and feasibility for improving the embryo qualities of embryo culture in-vitro.
Multi-Frame Binary-Phase Holograms Batched Optimization
Authors: Sha Jinze , Wojcik Antoni , Wetherfield Benjamin , Yu Jianghan , Wilkinson Timothy
Published: July 2024

Phase retrieval methods used in computer generated holograms (CGH) such as Gerchberg-Saxton (GS) and gradient descent give results which are prone to noise and other defects. This work builds up on the idea of time-averaging multiple hologram frames, first introduced in methods like One-Step Phase-Retrieval (OSPR) and Adaptive One-Step Phase-Retrieval (AD-OSPR). The proposed technique called Multi-Frame Holograms Batched Optimization (MFHBO) uses the L-BFGS optimization algorithm to simultaneously generate a batch of binary phase holograms which result in an average reconstructed image of improved fidelity and fast algorithmic convergence, both in the Fraunhoffer and the Fresnel regimes. The results are compared to OSPR and AD-OSPR in simulation and experimentally, proving the superiority of the proposed approach. This technique can be easily extended to other spatial modulation methods.
MSNet: A novel network with comprehensive multi-scale feature integration for gastric cancer and colon polyp segmentation
Authors: He Dongzhi , Li Chenxi , Ma Zeyuan , Li Yunqi
Published: July 2024

The precise and reliable segmentation of endoscopic images plays a pivotal role in the early diagnosis of gastrointestinal cancer lesions like gastric cancer and colon polyp. Due to the variations in appearance and blurred boundaries of cancer lesions, achieving precise automatic segmentation remains challenging. Therefore, this paper proposes a novel CNN-Transformer hybrid network named MSNet, which comprehensively utilizes multi-scale features. It aims to improve the segmentation accuracy of gastrointestinal cancer lesions by enhancing the ability to capture multi-scale features and distinguish boundaries. Firstly, a multi-scale perception module (MSPM) is designed specifically to capture and enhance multi-scale features, employing multiple pathways with stripe convolutions of various kernel sizes. Secondly, to enhance the model's ability to identify target boundaries, an improved dual feature pyramid (IDFP) strategy is proposed to obtain multi-scale prediction maps from various pathways and stages, thereby aggregating multi-scale features. Thirdly, to refine the network's recognition of target boundaries, a Boundary Enhancement Module (BEM) is devised, which integrates the multi-scale prediction maps obtained from IDFP with the final output of the decoder. This integration intends to mitigate spatial information loss caused by consecutive downsampling and upsampling operations, thereby achieving more precise segmentation outcomes. Extensive experiments are conducted on the privately collected gastric endoscopy dataset and five publicly available colonoscopy polyp datasets, aiming to assess the effectiveness and generalization of the proposed method. Results demonstrate that the proposed network achieves superior performance compared to other state-of-the-art methods in terms of accuracy. The source code will be available at https://github.com/0xChunFeng/MSNet.
Pattern Recognition Model for Identification of Healthy and Coronavirus Infected Samples Based on Optical Spectroscopy
Authors: Rumaling Muhammad Izzuddin , Chee Fuei Pien , Bade Abdullah , Juhim Floressy
Published: July 2024

This study proposes optical spectroscopy that utilizes the interaction of light with matter to identify healthy and virus-infected samples. The spectral differences between healthy and infected samples demonstrate the effectiveness of optical spectroscopy in differentiating infected samples from the healthy ones. However, optical spectral data contain numerous peaks which require additional expertise and time for interpretation. Thus, pattern recognition model is employed in conjunction with optical spectroscopy to enable practitioners to interpret results quickly. This study developed and evaluated the performance of several pattern recognition models in detecting SARS-CoV-2 in viral transport media (VTM). 75 healthy and 75 SARS-CoV-2 infected swab samples in separate vials of VTM were acquired and measured for ultraviolet absorbance, infrared absorbance and Raman spectral data. Four supervised classification algorithms, namely k-nearest neighbour (KNN), linear discriminant analysis (LDA), support vector machine (SVM) and artificial neural network (ANN), were developed with and without implementation of principal component analysis (PCA). A total of 8 pattern recognition models were developed using a training set and evaluated for performance. The results showed that the performance model predicts the class of testing set with generally higher performance when using Raman spectral data. Out of all the models predicting using Raman spectra, both LDA and SVM have the highest performance (accuracy, sensitivity and specificity of 100%). The application of PCA before the classification algorithm did not improve the performance of the models. The model developed in this study has demonstrated high performance in detecting SARS-CoV-2 infected samples, comparable to conventional detection methods.
Flux jumps, cluster distribution model and vortex phase diagram of oxygenated YBa2Cu3−xAlxO6+δ single crystal for H || ab
Authors: Babu Ashna , P. Sruthy S. , Jaiswal-Nagar D.
Published: July 2024

Flux jumps were observed in the magnetisation hysteresis loops of a single crystal of an oxygenated high temperature superconductor YBa2Cu3−xAlxO6+δ at fields similar to which symmetry reorientation transitions have been observed in small angle neutron scattering measurements of YBa2Cu3O6+δ previously. Bean’s critical state model was found to be insufficient to explain the observation of the flux jumps at fields larger than the field of full penetration. From x-ray photoelectron spectroscopy measurements, a single peak was observed in the spectra of Y, Ba, Cu and O, unlike the previous observation of double peaks in as-grown and oxygenated crystals. An aluminium substituted, oxygen vacant clusters of the kind (Al-O-Cu-..) n has been schematically made to explain the observation of the single peak in the XPS spectra. Similar to the observation of a field direction dependence in the as-grown crystal for µ0H || c, the second magnetisation peak anomaly was observed to have a field direction dependence for µ0H || ab, but only at low temperatures. At temperatures larger than 25 K, the second magnetisation peak anomaly was found to be field direction independent. The onset and peak fields were found to comply to an order-disorder transition at such fields and temperatures. The flux jump line was also found to fit with an order-disorder transition suggesting an intimate link between symmetry reorientation transition and the state of spatial order in the vortex lattice of oxygenated YBa2Cu3−xAlxO6+δ single crystal µ0H || ab. Incorporating all features in the magnetisation hysteresis loop, a vortex phase diagram has been made for oxygenated YBa2Cu3−xAlxO6+δ for µ0H || ab depicting various phases.
Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer
Authors: Giorgio Eros Di , Tolotto Vanessa , Gualandi Nicolò , Colitti Monica , Picco Raffaella , Cortolezzis Ylenia , D'Este Francesca , Gani Mariachiara , Hancock Wayne , Terrosu Giovanni , Degrassi Cristina , Brancolini Claudio , Xodo Luigi
Published: July 2024

Epigenetic plasticity and large-scale chromatin remodeling characterize tumor evolution and the emergence of subclones resistant to conventional therapies. Catalytically inactive class IIa HDACs (HDAC4, HDAC5, HDAC7, HDAC9) control the targeted recruitment of chromatin remodeling complexes, making them attractive therapeutic targets in oncology. In this study, we found that HDAC4 is proteasomal degraded in cancer cells impaired in DNA repair by homologous recombination. Genetic screening identified FBXW7 as the E3 ligase responsible for this degradation. FBXW7 loss-of-function mutations are frequently found in patients with colorectal cancer (CRC) and associated with the development of resistance to Oxaliplatin. Forced degradation of HDAC4 using a PROTAC-based compound restored oxaliplatin sensitivity in FBXW7-mutated CRC cells, patient-derived organoids (PDOs) and in mice. Mechanistically, removal of HDAC4 in FBXW7-mutated CRC cells and PDOs treated with oxaliplatin resulted in a profound restructuring of the super-enhancer landscape by restoring a super-enhancer repertoire typical of Oxaliplatin-sensitive cells. Furthermore, patient profiling based on the epigenetic state of super-enhancers controlled by HDAC4 successfully identifies a priori CRC patients resistant to platinum. This study supports HDAC4 as a key mediator of oxaliplatin resistance in FBXW7-mutated CRC and underlines the remodeling of a well-defined repertoire of super-enhancers as part of the process of re-sensitization.
Estimation of High-resolution Digital Elevation Model (DEM) From Sar Data Over the Confluence Region
Authors: Abubakar Ahmadu Ali , D. Dodo J. , O. Abubakar N.
Published: July 2024

Estimating a wide area high resolution digital elevation model (DEM) over the confluence region of Nigeria from sentinel-1synthetic aperture radar (SAR) data is crucial. This study leveraged geospatial technology to gain critical insights into the region's hydrology, terrain information and characteristics. These components play a crucial role in estimating the surface roughness of terrains for flood control and mitigation efforts, enabling the identification of areas vulnerable to erosion, rapid runoff, potential floodplains and possible drainage basins. The implications of this research are significant because it provides precise data for flood modeling, early warning systems, urban planning, watershed management and different types of possibly agriculturally influenced activities that are viable in the Confluence region. The research captured elevation values ranging from 79.59 meters to 529.27 meters. These detailed digital elevation model data allowed for precise terrain analysis, facilitating the identification of flood-prone areas, elevation extremes, and drainage patterns. A contour map was also generated from the DEM data, featuring contour intervals of 100 meters, which provides a clear visualization of the region's topography. Furthermore, the study delved into the analysis of key hydrological components, including slope, aspect and flow direction. As floods become increasingly severe and exacerbated by climate variables, these findings provide a foundation for building resilient communities and sustainable flood mitigation measures. The results underscore the major role of geospatial technology in addressing hydrological challenges and emphasize the importance of data-driven decision-making for a more secure and sustainable future in the face of evolving climate patterns.
Sustainable Hydroponics Using Zero-discharge Nutrient Management and Automated pH Control
Authors: Langenfeld Noah James , Bugbee Bruce
Published: July 2024

Here we review the 400-year history of hydroponic culture and describe a unique management approach that does not require leaching or discarding solution between harvests. Nutrients are maintained at a low and steady concentration by daily additions of a dilute solution that replaces the transpired water along with the nutrients that were removed in growth each day. A stable pH and a low steady-state concentration of ammonium are maintained through automated additions of a solution of nitric acid and ammonium nitrate. Ample solution volume (at least 20 cm deep) stabilizes nutrient concentrations, reduces root density, and improves uniformity. Gentle aeration at ≈100 mL·min−1·L−1 maintains dissolved oxygen near saturation and increases uniformity throughout the rhizosphere. These practices facilitate a uniform, closed, root zone with rigorous pH control that provides the micromolar nutrient concentrations of N and P that are representative of field soils.
Türkiye Cumhuriyeti’nde Kadın İşgücü ve İstihdamı: Kalkınma Planları Perspektifinden Bir İnceleme
Authors: Denizli Adviye Aslı
Published: July 2024

Bu çalışmanın amacı kalkınma planları çerçevesinde ülkemizde kadınların işgücüne katılımı ve istihdamının, nitel araştırma deseni izlenerek doküman analizi aracılığı ile incelenmesidir. Araştırmanın kapsamını oluşturan 1963-2023 arasındaki dönemde hazırlanan beşer yıllık on bir kalkınma planında, öncelikle analiz birimi olarak seçilen “kadın” sözcüğünün kaçar kez yer aldığı belirlenerek tablolaştırılmıştır. Kalkınma planlarında, araştırmanın amacı doğrultusunda kadın işgücü ve kadınların istihdamına ilişkin temalar belirlenmiştir. Bu temaların belirlenmesinde, kadınların işgücü ve istihdamlarına etki edebilecek değişkenler seçilerek nüfus, sağlık, eğitim-meslek, istihdam ve kadın hakları olmak üzere beş tema oluşturulmuştur. Belirlenen bu temalar altında, “kadın” sözcüğünün kaçar kez yinelendiği saptanarak tablo hâlinde sunulmuştur. İlgili temalara dair bulgular, kalkınma planlarından alıntılara da yer verilerek yorumlanmıştır. Çalışma kapsamında, Cumhuriyetimizin yüzüncü yılına ulaşırken ülkemizdeki kadın işgücü ve istihdamına, istatistikler aracılığıyla ışık tutulabilmesi için seçilmiş bazı istatistiklere de yer verilmiştir. Altmış yıllık dönemi kapsayan kalkınma planları ile kadınların eğitim düzeylerinin yükseltilmesi, niteliklerinin artırılması, istihdam edilebilirliklerinin geliştirilmesi, çalışma yaşamına katılmaları ve bunu sürdürebilmeleri yolunda, özellikle 1970’lerden başlayarak önemli adımlar atıldığı görülmektedir. Ancak kalkınma planlarıyla hedeflenenlerin, henüz istenilen düzeyde gerçekleştirilemediği anlaşılmaktadır. Kalkınmanın sürdürülebilir kılınması, günümüz toplumlarının önemli gündem maddeleri arasındadır. Bu çerçevede, kadınların güçlendirilmeleri için atılacak iyileştirme adımlarının sürdürülmesi ve bu adımların uygulamadaki etkinliğinin takip edilerek artırılması, gelecek için de önemini korumaktadır.
Archicarbons: New Carbon Allotropes Build from Circular Arches of Carbon Atoms as Building Blocks
Authors: Henrique Fabio , Oliveira Felipe , Esteves Pierre
Published: July 2024

Molecular and periodic allotropes based on cyclo[18]carbon, known as archicarbons, were investigated using density functional theory (DFT) in both molecular and periodic models. This study explores the physicochemical characteristics of these exquisite carbon allotropes, including various molecular archicarbons (spiro[18]carbon, bicyclo[8]carbon, 0-tricyclo[8] carbon, 0-bi(cyclo[19]carbon), 1-bi(cyclo[19]carbon), and 0-fused[18]carbon) and periodic archicarbons (poly-spiro[8]carbon, poly-0-bi(cyclo[8]carbon), poly-1-bi(cyclo[8]carbon)). Most proposed molecular archicarbons showed higher cohesive energy than cyclo[18]carbon, except for bicyclo[8]carbon, which suggests that those may be experimentally observable. Proposed synthetic routes for both molecular and periodic archicarbons are suggested, highlighting their potential, particularly in semiconductor applications, and paving the way for further exploration of their distinct electronic properties.
Spatio-temporal analysis of meteorological drought return periods in a Mediterranean arid region, the center of Morocco
Authors: Hadri Abdessamad , Ndiaye Assane Salame , Khadir Lahcen , Jaffar Oumar , Zamzami Hamza Ait , Mahdi El Khalki El , Amazirh Abdelhakim , Bouchaou Lhoussaine , Chehbouni Abdelghani
Published: July 2024

Morocco has recently witnessed a surge in drought occurrences, leading to considerable socioeconomic damage. The standardized precipitation index (SPI) at three- and 12-month timescales was employed to assess spatiotemporal drought characteristics across the Marrakech-Safi arid region. Mann–Kendall and Sen's slope methods were adopted to assess SPI trends. Furthermore, the Gumbel copula was employed to construct the joint distribution function of three drought variables: duration, severity, and intensity. The spatial distribution of drought return period for different scenarios was carried out. Results revealed notable interannual fluctuations of wet and drought cycles, with the driest years being 1983 and 2005 and a mixture of positive and negative trends of SPI-12 and SPI-3 over the 1972–2018 period. Nevertheless, statistical significance was observed in only 50% of the SPI-12 trends and 27% of the SPI-3 trends. The drought severity in the region was highest in the plain area, with droughts lasting 6–20 months for 75% of all drought events for SPI-12. The coastal strip exhibited the lowest drought recurrences. Furthermore, dry periods exhibited greater temporal variability over shorter timescales. Finally, trivariate return periods of drought events were the longer, averaging 93 months for SPI-12.
Extreme precipitation events in the Brahmaputra River basin during the Indian summer monsoon and its association with atmospheric moisture transport
Authors: Gupta Hariom , Raghuvanshi Akash Singh , Agarwal Ankit
Published: July 2024

Due to climate change, rising temperatures cause the atmosphere to hold more moisture, likely increasing the frequency and intensity of extreme precipitation events. These events, lasting several days, are the leading causes of floods. Recently, floods from multi-day precipitation extremes (MPEs) have risen significantly. The Brahmaputra River basin (BRB) in India is particularly vulnerable to flooding during the Indian summer monsoon due to its transboundary nature. It is crucial to characterize and rank MPEs to understand their risk, impact, and underlying drivers. This study ranked MPEs of different durations based on intensity and spatial extent during the Indian summer monsoon over the BRB using a high-resolution daily precipitation dataset from 1951 to 2022. In addition, it evaluates the association between atmospheric moisture transport and MPEs by quantifying integrated water vapor transport (IVT) during top-ranked MPEs. The analysis indicates intense IVT in the mid-tropospheric layer (850–500 hPa) over the MPE regions during top-ranked events and identifies significant low-pressure anomalies and shifts from ridge to trough patterns. Quantifying the connection between MPEs and IVT can aid in early prediction and risk reduction.
What have we learnt as orthopaedic surgeons? Pandemic surveillance of surgically treated fracture patients
Authors: Taşcı Murat , Duman Sedat , Özdamar İhsan
Published: July 2024

Aim: To investigate the epidemiological and demographic data of the patients operated on during the first wave of the pandemic, and to analyze what the pandemic has taught orthopedic surgeons

Methods: In this retrospective analysis, 90 patients who were operated in our clinic were analyzed. Demographic data, injury mechanism, fracture site, anesthesia type, the number of consultations after admission, the comorbidities, average time between first admission to hospitalization, the length of stay in the intensive care unit (ICU), and neutrophil-lymphocyte ratio (NLR) were investigated.

Results: Higher incidence of hip fractures was observed in COVID-positive patients (p
Dynamic Comparison of Binding Pocket of Berberine Protein Crystals
Authors: Ma Jin-Rong , Huang Qiu-Rong , Man Ruo-Jun , Zhao Linguo , Li Dong-Dong
Published: July 2024

Introduction:

Berberine is an important isoquinoline alkaloid that has various pharmacological
properties. The comparison of the binding pocket similarity of berberine is regarded as the
starting point for deciphering various activities. Eight berberine protein crystals were clustered and
studied by molecular dynamics (MD) simulations to investigate common features of berberine binding
pockets.

Methods:

Root Mean Square Deviation (RMSD) results showed that berberine was able to bind to
each protein in a stable manner. Residue analysis showed that the stability of residue composition of
different protein pockets varied. This is also consistent with the results of the pocket similarity analysis:
PS-score curves of most proteins fluctuated to varying degrees. The binding pocket of 3BTI in
homogeneous protein analysis exhibited high stability (PS-scoremean = 0.703 and PS-scoremin =
0.5664). Pocket similarity analysis between two heterologous proteins showed that most of PS-score
values were in the interval of 0.3-0.35, and PS-score values of 3D6Y were relatively high when
compared with the other three proteins.

Results:

Pocket residue matching analysis showed that GLU145/VAL147/ILE182/TYR229/GLU253
in 3D6Y can be matched structurally to the corresponding residues in 1JUM, 2QVD, and 5Y0V,
respectively, which can be considered as an important pocket feature for the berberine binding. Nevertheless,
the obtained matched residues are limited to the category of pocket structural similarity.

Conclusion:

This was the first study in which dynamic comparison of berberine binding pockets
were used to discover pocket patterns. These results were of great significance for the polypharmacological
study, the identification of potential off-targets, and the repurposing of berberine.
Design of New Aromatic Tertiary Amine-based as Butyrylcholinesterase Inhibitors Relying on Molecular Docking, ADME-Tox and Molecular Dynamics
Authors: Qara Abdelhamid , Ouabane Mohamed , Sekkate Chakib , Chtita Samir , Lakhlifi Tahar , Bouachrine Mohammed
Published: July 2024

Introduction:

Butyrylcholinesterase (BChE) plays a pivotal role in the progression of
Alzheimer's disease. Empirical research demonstrated a fundamental alteration in the role of
BChE concerning the reduction of cholinergic neurotransmission within the brains of individuals
at advanced stages of Alzheimer's.

Method:

This study focuses on developing potent inhibitors for Butyrylcholinesterase (BChE) in
the context of Alzheimer's disease (AD) treatment. Building upon previous research, a series of 44
aromatic tertiary amine-based compounds was investigated. Starting with ADME-Tox studies, the
pharmacokinetic and pharmacodynamic properties of the compounds were analyzed to select
promising candidates for BChE inhibition, which is a crucial factor in AD pathology.

Results:

Molecular docking analyses identified compound M18 as the most promising candidate,
and further compounds (X9 and X10) were proposed based on M18's chemical structure. These
compounds displayed superior properties in terms of binding energies and hydrogen bonds in comparison
to M18.

Conclusion:

The Molecular Dynamics (MD) simulations, which are over a 500 ns timeframe, confirmed
the conformational stability of compounds X9 and X10, compared to M18. Overall, the
stated results suggest that the proposed compounds, including X9 and X10 specifically, have a significant
potential as candidates for BChE inhibition. This presents a promising avenue for therapeutic
intervention in Alzheimer's disease.
Estimation and Decision Theory
Authors: Polanco Carlos
Published: July 2024

 This chapter covers the basic concepts of inferential statistics and hypothesis testing. The section commences with an explanation of the confidence intervals for the population mean and population standard deviation. Also discussed
are the concepts of cut-off, Type I and Type II errors, false positives, and false negatives. We investigate performance metrics including sensitivity, specificity, true
positive rate, and true negative rate. In addition, receiver operating characteristic
(ROC) curves are introduced and their usefulness in assessing test performance is
emphasized. In addition, binomial and normal distribution tests are discussed. This
chapter provides a solid foundation for comprehending the principles and practical applications of inferential statistics in decision-making and the interpretation of
scientific results. 
Multivariate Analysis of Variance
Authors: Polanco Carlos
Published: July 2024

This chapter examines the analysis of variance (ANOVA) and Fisher
statistical tests as fundamental research methods. Introduction to ANOVA and its
application to the investigation of significant differences between data groups. Subsequently, we examine the application of Fisher tests in various contexts, including one-factor, two-factor, and even three-factor analyses. In addition, we investigate the design and experimental application of Latin squares. We conclude by
discussing multivariate analysis of variance (MANOVA) and emphasizing its usefulness for investigating multiple response variables. This chapter concludes with
a comprehensive overview of the previously mentioned statistical techniques and
their applicability to scientific research.
Crenças dos professores face às medidas de intervenção para promover o sucesso escolar: Que relação com a retenção escolar?
Authors: Santos Natalie Nóbrega , Monteiro Vera
Published: July 2024

Portugal apresenta uma das taxas de retenção escolar mais elevadas na Europa, especialmente no 2.º ano de escolaridade. O uso frequente da retenção sugere que os professores acreditam na sua efetividade apesar dos dados da literatura indicarem que tem efeitos nulos e/ou negativos. O presente estudo procurou compreender as crenças dos professores de 1.º ciclo sobre a efetividade e a dificuldade de implementação de medidas de intervenção utilizadas pelos professores para promover o sucesso escolar no 2.º ano de escolaridade, e como se relacionam com as suas crenças e práticas de retenção escolar. Participaram 273 professores do 1.º ciclo do ensino básico, da Região Autónoma da Madeira, que responderam a um questionário online. Os resultados indicaram que os professores consideram a retenção escolar menos efetiva que outras medidas, mas moderadamente efetiva para a promoção do sucesso escolar. O apoio individualizado e a redução do número de alunos por sala foram consideradas as medidas mais efetivas. Os professores também consideraram a retenção mais fácil de implementar que o acompanhamento familiar e o apoio psicopedagógico. Uma análise de trajetórias indicou que os professores que acreditavam mais na efetividade da retenção e do apoio individualizado e os que consideraram mais difícil a promoção de competências socioemocionais retiveram mais alunos no 2.º ano de escolaridade. Os resultados sugerem a importância do desenvolvimento de estratégias de diferenciação pedagógica, da promoção de competências socioemocionais e do envolvimento da família, que poderão contribuir para reduzir o uso da retenção escolar e promover o sucesso escolar.
Legal regime of personal data of persons participating in civil proceedings
Authors: Elizarova M. Y.
Published: July 2024

Relevance.Unlike personal data of a person, personal data of participants in civil proceedings are posted without exception in the texts of decisions on the websites of courts, voiced in video broadcasts, and published in the public domain by search aggregator sites. The article analyzes the concept and content of the legal regime of personal data of persons participating in civil proceedings in relation to the problem of their protection. The legislation on personal data and on ensuring access to information on the activities of courts in the Russian Federation are being studied, establishing the legal regime of personal data of persons participating in civil proceedings in relation to the problem of their protection.

The purposeof the study is to deepen scientific knowledge about the essence of the legal regime of personal data of participants in civil proceedings, to develop theoretical concepts and legislative proposals to increase the effectiveness of their protection.

Objectives:analyze the legislation governing the legal regime of personal data of persons participating in civil proceedings, identify legal means to ensure their protection, and identify legislative gaps that impede their proper protection.

Methodology.The research methodology is represented by general scientific (dialectical, analysis and synthesis of deduction, induction) and private scientific methods (formal-legal, formal-logical, system-analytical).

The resultsfound expression in the formulated concept of the legal regime of personal data of participants in civil proceedings, identifying its correlation with the legal regime of personal data of individuals, as well as in proposals for improving the current norms of the Code of Civil Procedure of the Russian Federation, establishing the rules for conducting video broadcasts of court hearings, to protect personal data of the considered category of citizens.

Conclusion.The legal regime of personal data of participants in civil proceedings is a procedure for regulating public relations, expressed in a set of legal means aimed at ensuring, in the interests of the whole society, the availability of information about judicial activities, and the protection of personal data of persons participating in civil proceedings. The legal regime of personal data of participants in civil proceedings correlates with the legal regime of personal data of individuals as private and general, and therefore is special in type.
A Machine Learning Model for Predicting In-Hospital Mortality in Chinese Patients With ST-Segment Elevation Myocardial Infarction: Findings From the China Myocardial Infarction Registry (Preprint)
Authors: Yang Jingang , Li Yingxue , Li Xiang , Tao Shuiying , Zhang Yuan , Chen Tiange , Xie Guotong , Xu Haiyan , Gao Xiaojin , Yang Yuejin
Published: July 2024

BACKGROUND

Machine learning (ML) risk prediction models, although much more accurate than traditional statistical methods, are inconvenient to use in clinical practice due to their nontransparency and requirement of a large number of input variables.

OBJECTIVE

We aimed to develop a precise, explainable, and flexible ML model to predict the risk of in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI).

METHODS

This study recruited 18,744 patients enrolled in the 2013 China Acute Myocardial Infarction (CAMI) registry and 12,018 patients from the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE)-Retrospective Acute Myocardial Infarction Study. The Extreme Gradient Boosting (XGBoost) model was derived from 9616 patients in the CAMI registry (2014, 89 variables) with 5-fold cross-validation and validated on both the 9125 patients in the CAMI registry (89 variables) and the independent China PEACE cohort (10 variables). The Shapley Additive Explanations (SHAP) approach was employed to interpret the complex relationships embedded in the proposed model.

RESULTS

In the XGBoost model for predicting all-cause in-hospital mortality, the variables with the top 8 most important scores were age, left ventricular ejection fraction, Killip class, heart rate, creatinine, blood glucose, white blood cell count, and use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). The area under the curve (AUC) on the CAMI validation set was 0.896 (95% CI 0.884-0.909), significantly higher than the previous models. The AUC for the Global Registry of Acute Coronary Events (GRACE) model was 0.809 (95% CI 0.790-0.828), and for the TIMI model, it was 0.782 (95% CI 0.763-0.800). Despite the China PEACE validation set only having 10 available variables, the AUC reached 0.840 (0.829-0.852), showing a substantial improvement to the GRACE (0.762, 95% CI 0.748-0.776) and TIMI (0.789, 95% CI 0.776-0.803) scores. Several novel and nonlinear relationships were discovered between patients’ characteristics and in-hospital mortality, including a U-shape pattern of high-density lipoprotein cholesterol (HDL-C).

CONCLUSIONS

The proposed ML risk prediction model was highly accurate in predicting in-hospital mortality. Its flexible and explainable characteristics make the model convenient to use in clinical practice and could help guide patient management.

CLINICALTRIAL

ClinicalTrials.gov NCT01874691; https://clinicaltrials.gov/study/NCT01874691
Human Guide Training to Improve Hospital Accessibility for Patients who are Blind: Needs Assessment and Pilot Process Evaluation (Preprint)
Authors: James Tyler G. , Hughes Sarah , Moran Christa , Day Sherry , McKee Michael M.
Published: July 2024

BACKGROUND

People with disabilities are a priority population for health services research. People who are blind/low vision (B/LV) are a segment of this priority population, who experience difficulty to accessing healthcare facilities due to architectural and navigational barriers. These barriers persist despite disability civil rights law in the U.S.

OBJECTIVE

The purpose of this manuscript is to report on a program that was developed to train way finders in human guide technique for people who are B/LV.

METHODS

This study took place at Michigan Medicine, an academic medical center in southeast Michigan. We conducted a needs assessment through cohort discovery and soliciting expert feedback. The human guide training program was developed using the PRECEDE-PROEED health promotion program development model, and targeted healthcare volunteers and staff. The intended components included in-person training, an online module, and tip sheets. Due to COVID-19, the in-person training was not implemented. We report findings from a process evaluation, measuring reach, knowledge, behavioral capability, and satisfaction pre- and post-program.

RESULTS

87 participants completed the training, most of them were Michigan Medicine volunteers. There were significant improves in behavioral capability related to human guide technique. Participants were satisfied with the training, and provided recommendations for more detailed demonstrations and scenarios in future training sessions.

CONCLUSIONS

The training improve participants’ knowledge and confidence in providing wayfinding assistance to patients who are B/LV. However, further in-person training is recommended to provide hands-on experience and detailed feedback. Addressing architectural barriers and providing accessible patient education materials is crucial for improving healthcare accessibility for patients who are B/LV.
Um estudo da tradição oral a partir do conto Cinderela
Authors: Melo Sirlai
Published: July 2024

O presente estudo busca demonstrar a maneira como as narrativas orais permaneceram ao decorrer do tempo, adequando-se com o contexto contemporâneo, estabelecendo assim uma relação de tradição e ruptura. Para isso, especificam-se os seguintes objetivos: identificar, através das narrativas orais, como a tradição é mantida com o passar do tempo e de que forma as rupturas dão continuidade às narrativas dentro de um novo e atual contexto histórico; e, por fim, apresentar como as variações permitem que essas narrativas se fixem na memória coletiva. Para tanto, realizou-se uma pesquisa de natureza qualitativa bibliográfica, através da qual foi feita a seleção do conto “Cinderela” na versão de Charles Perrault (1697), uma versão escrita dos irmãos Grimm (1812) e duas versões orais narradas por Lélia Dantas (COSTA, 1998) e Sônia Pinto (COSTA, 2009). Feita a análise literária das variantes selecionadas, por meio do método comparativo, foram percebidos os distanciamentos e aproximações entre essas obras, além de identificar o significado das funções femininas (MENDES, 2000) apresentadas nessas versões. Como suporte teórico foram utilizados textos de autores como: Alcoforado (2007), Bâ (2010), Burke (1992), Costa (2015), Fernandes (2003), Silva (2011), Zumthor (1997), entre outros.
MORTALIDADE POR MELANOMA MALIGNO NO BRASIL ENTRE OS ANOS DE 2013 E 2022: Tendências regionais, em relação ao gênero, etnia e à faixa etária
Authors: Silva Marcelo Vinícius Pereira , Alencar Joaquim Eduardo Figueira Farias , Abreu Isabela Silva Dugué de , Lima Ana Vitória da Costa , Junior Elizeu Augusto de Freitas
Published: July 2024

Introduction: Skin cancer is the most common type of cancer in Brazil, with a high cure rate if treated early. Melanoma, an aggressive type of skin cancer, accounts for 79% of deaths from skin cancer. Its incidence is increasing globally due to sun exposure and other behavioral changes. This study analyzes mortality from cutaneous melanoma in Brazil, considering regional, gender, and ethnic factors. Methodology: Retrospective and observational study based on data from the Mortality Information System (SIM) from 2013 to 2022. Data on deaths from malignant melanoma of the skin were analyzed across various regions, genders, age groups, and ethnicities. Relevant literature selection was conducted through searches in BVS and PubMed. Results: The mortality rate from melanoma ranged from 1,547 to 1,959 deaths annually from 2013 to 2022. The Southeast region had the highest number of deaths, followed by the South and Northeast. The Southeast recorded a total of 7,821 deaths during the period, while the North had the lowest number, with 471 deaths. Men were more affected than women, accounting for 57.5% of deaths. White ethnicity accounted for 82.1% of deaths. Mortality increased progressively with age, stabilizing after age 70. Discussion: Melanoma mortality exhibited fluctuating patterns in Brazil, with peaks in 2019 and declines in 2020-2021. Regional disparities reflect differences in healthcare access, cultural habits, and socioeconomic factors. Higher mortality among men may be linked to greater exposure to risk factors and lower rates of early diagnosis. The high incidence among white individuals underscores the need for specific health policies. Preventive strategies should focus on raising awareness about sun exposure, early diagnosis, and improving healthcare infrastructure. Conclusion: The study highlights the need for public health policies tailored to regional specificities to reduce melanoma mortality in Brazil. Awareness campaigns, screening programs, and improved treatment access are essential to mitigate the effects of cutaneous melanoma.
REMOÇÃO CIRÚRGICA DE DENTE SUPRANUMERÁRIO EM PACIENTE PEDIÁTRICO: Relato de caso em Mato Verde - MG
Authors: Camargo Carlos Eduardo Antunes , Freitas Tiago Vinícius Santos , Vieira Jr José Jotha , Rocha Marcone de Oliveira , Rego Daniela Daianne Sousa , Guimarães Luiz Daniel dos Santos , Almeida Gabriela Lourenço Alves , Chagas Pablo Vinicyus Ferreira
Published: July 2024

Supernumerary dental elements represent a condition in which there is the presence of excess dental elements in relation to the normal number in the arches, which can manifest itself both in childhood and in adult life. The objective of this study was to report a clinical case of surgical removal of a supernumerary tooth in a four-year-old patient. This is research with a qualitative approach and exploratory/descriptive objectives, using clinical case study procedures. The research was carried out in the municipality of Mato Verde-MG at Faculdade Verde Norte (FAVENORTE). The person responsible for the four-year-old female patient came to the Favenorte school clinic with the following main complaint: “Removal of a supernumerary tooth”. The patient's guardian reported that she had previously sought another professional, who had given the diagnosis. On clinical examination, the presence of a supernumerary tooth was observed in the anterior region between the primary central incisors in the palate region. Teeth 51, 52, 61 and 62 had their coronal portions destroyed and did not present the possibility of rehabilitation, due to the quality of the root remnants. Radiographic examination can confirm the presence of a supernumerary tooth. After removing the root residue, surgery was planned to remove the supernumerary tooth, with the aim of preventing future dental problems. It is essential that professionals are aware of the characteristics of this anomaly and that this treatment is as conservative as possible, thus enabling a satisfactory postoperative period for the patient.
VICTORIO PESCIO VARGAS Y LA RENOVACIÓN DEL DERECHO CIVIL DESDE VALPARAÍSO
Authors: Alcalde Silva Jaime
Published: July 2024

El presente trabajo expone la vida de Victorio Pescio Vargas mirado como un jurista. Comienza con un esbozo biográfico que permite situar el tiempo durante el cual vivió y los principales hitos de su historia personal. Después se explica la contribución que supuso su trabajo en el campo jurídico, separando el ejercicio profesional, la gestión universitaria, la docencia y la obra escrita, con especial énfasis en su Manual de Derecho civil inconcluso que contribuyó a remozar el género en Chile. En fin, se ofrece un poema de Gonzalo Villar Bordones, que resume la trayectoria vital de este destacado profesor y director de la Escuela de Derecho de Valparaíso, cuyo edificio fue su gran legado material.
EL DELITO DE BENEFICIO CLANDESTINO DE GANADO
Authors: Bascur Retamal Gonzalo
Published: July 2024

El texto realiza un análisis dogmático del tipo delictivo previsto en el artículo 3 de la ley 11.564, focalizado en castigar la actividad de procesamiento ilegal de carne de ganado para su comercialización con fines de alimentación humana en todas sus etapas, ofreciendo una propuesta interpretativa de su contenido, con especial énfasis en sus condiciones de aplicación y en las consecuencias jurídicas que implica su perpetración.
Impact of COVID-19 Infection in Kidney Transplant Patients: A Review
Authors: ATM Zafrul Azam
Published: July 2024

Managing COVID-19 in kidney transplant patients is complex due to limited data on its severity, treatment, and management. Conflicting information from studies necessitates case-by-case treatment decisions. Atypical symptoms can lead to misdiagnosis, so a thorough evaluation is crucial. Immunosuppressants and comorbidities can worsen the disease, leading to the controversial approach of discontinuing or reducing immunosuppressive drugs. Kidney transplantation is challenging due to the surgical procedure’s sensitivity and high risk of transmission. While vaccines offer protection, their efficacy may be altered by immunosuppressive drugs in these patients. This review summarizes the management of COVID-19 in kidney transplant patients, addressing these complexities. Kidney transplant patients face unique COVID-19 challenges due to weakened immunity. They are at higher risk for severe illness and complications from both the virus and immunosuppressant medications. Early identification and intervention are crucial, including antiviral treatment like remdesivir in severe cases. Managing immunosuppressants is critical to balancing the risk of transplant rejection with COVID-19 severity. Drug interactions with COVID-19 treatments require careful consideration, potentially necessitating dose adjustments or alternative medications. The pandemic has disrupted transplant services, highlighting the need for prioritized vaccination and safe access to care. Telemedicine can help minimize virus exposure during post-transplant follow-up. While immunosuppression may impact vaccine responses, vaccination remains crucial to reducing the severe COVID-19 risk. Booster doses and continued precautions are important. Mental health support is essential to address pandemic-related anxiety, depression, and social isolation. More data is needed on the safety and effectiveness of COVID-19 treatments and vaccines in this population. A multidisciplinary approach, including close monitoring, careful medication management, vaccination, and psychosocial support is needed to optimize management and improve outcomes.
Effect of Contrast Agents on Pregnant Women
Authors: Arfat* Mohd , M Yousuf
Published: July 2024

Many clinical conditions require radiological diagnostic exams based on the emission of different kinds of energy and the use of contrast agents. Pregnant patients who should be submitted for diagnostic examinations with contrast agents represent a group of patients with whom it is necessary to consider both maternal and fetal effects. Radiological examinations use different types of contrast media, the most used and studied are represented by iodinate contrast agents, gadolinium, Gastrograffin, barium sulfate. The present article reports the available data about each contrast agent and its effect related to the mother and fetus. This review aims to clarify the clinical practices to follow in cases where a radio diagnostic examination with a contrast medium is indicated to be performed on a pregnant patient.
ÍNDICE DE VEGETAÇÃO POR DIFERENÇA NORMALIZADA (NDVI) NA ANÁLISE DA COBERTURA VERDE EM PRAÇAS E PARQUES DE TERESINA – PI
Authors: Oliveira Deisy Nayanny de Brito Silva , Lopes Wilza Gomes Reis , Oliveira José Jeremias Fernades de , Matos Karenina Cardoso
Published: July 2024

Conhecida por apresentar altas temperaturas, a cidade de Teresina necessita da presença de áreas com vegetação, destacando-se as árvores, que contribuam para a regulamentação climática. que além da importância ambiental e cultural dos espaços livres de edificação para a qualidade ambiental, deve-se considerar, também, seu valor recreativo e de convivência para os habitantes das cidades. O processo acelerado de ocupação e expansão urbana nas últimas décadas do Brasil, reservou poucos locais que possam representar oportunidades de lazer e convívio para a população e, principalmente, de preservação dos recursos naturais. Diante do exposto, este estudo tem como objetiva analisar a cobertura verde em Praças e Parques Ambientais de Teresina-PI através dos índices de cobertura vegetal, percentual de cobertura vegetal e cobertura verde nas Zonas Administrativas do município de Teresina no Estado do Piauí através do índice de vegetação por diferença normalizada. A cobertura vegete per capita em Teresina é de 167,27 m², porém quando estratificado para praças e parques este valor varia para menos um metro quadrado até nove, a depender da zona. Logo em Teresina a distribuição de espaços verdes em praças e parques não possui equidade, assim como a porcentagem de cobertura verde nas praças e parques.