bluuebunny/crossref_metadata_2025 huggingface dataset:
Occurrence of Malaria in HIV/AIDS Patients at Ishaka Adventist Hospital, Bushenyi District, Uganda.
Authors:   Department of Clinical Medicine Kampala International University, Uganda., Ritah Nassuna
Published: April 2023

The study assessed the prevalence of malaria in HIV/AIDS patients attending HIV clinic at Ishaka Adventist Hospital, the study objectives were to determine the proportion of HIV patients with malaria, to identify the clinical manifestations of malaria among HIV positive patients and to review different techniques used in diagnosis of malaria at Ishaka Adventist Hospital in Bushenyi district. A descriptive cross sectional study was used for known HIV positive patients attending Ishaka Adventist Hospital and involved systematic random sampling of participants. The study found out that malaria prevalence was high among HIV patients at 9.8%, nearly all patients who were diagonised with malaria reported having had fever previously 87.1% , the presentation of malaria can better be assesed as uncomplicated malaria and complicated malaria and in this study majority of the signs assessed were of uncomplicated malaria, diagnostic measures of laboratory remain the most perfect way of diagnosing malaria other than clinical assessment especially in HIV patients who are immunocompromised nd can be ill of various oppotunistic infection. Although various methods have been advanced to curb malaria epidemic , the prevalence is still high, so the the following are recommendation; the government should distribute more mosquito nets especially those whoare immunocompromissed like HIV patients, agencies for fighting malaria and those of HIV should work together inorder to reduce the number of HIV patients getting malaria infection, patients should be health educated on the main signs and symptoms of malaria such that they can quickly seek medical attention incase of the need, patients should be encouraged to take their ARVs to maintain their immunity relatively high so that they are not severely affected by malaria. Keywords: Ishaka, Adventist Hospital, Malaria, Immunocompromised, Infection.
Design and Implementation of a Smart Surveillance Security System
Authors:   Department of Electrical Engineering, Kampala International University, Uganda., Edozie Enerst , Hyginus Udoka Eze Val ,   Department of Publication and Extension, Kampala International University, Uganda., Immaculate Musiimenta ,   Department of Electrical Engineering, Kampala International University, Uganda., Janat Wantimba ,   Department of Electrical Engineering, Kampala International University, Uganda.
Published: April 2023

Home security is essential for occupant’s conveniences and protection. This research project designed and implemented a comparatively inexpensive smart surveillance security system that automatically captures an intruder’s image through a raspberry pi camera module and PIR sensor and sends mail to the user via Wi-Fi using the users registered email address. This system operates by triggering the Pi Camera through Raspberry Pi whenever an intruder comes in range using PIR sensor. The Pi camera will capture the image, save it and send the image of the intruder via mail to the user through the help of the command codes embedded in the Raspberry pi microcontroller. This research project will enable home/supermarket and office owners to secure their facilities and monitor the activities of their employers at any location at cheaper cost which is the earnest desire of an Engineer. Proteus 2022 was used as the simulation tool. Keywords: Security, Spy camera, Raspberry pi, IOT, smart security system.
Meditation and Health: Becoming Healthy and Reversing Age by Controlling our Monkey Mind
Authors: Shakya Dipesh
Published: April 2023

N/A
RANCANG BANGUN DAN ANALISA BISNIS MINIMUM VIABLE PRODUCT DISTRO MANAGEMENT SYSTEM (DIMANS.CO.ID)
Authors: Suryana I Putu Agus Priska , I Putu Satwika  , I Gusti Bagus Made wiradharma  , Wisnu Adhi Saputra
Published: April 2023

Football is one sport that really enjoy doing around the world, football is played by millions of people, whether male or female, young or old, tall or short people person so football became the most popular sport in the world. Almost everyone can play football, because football is a sport that is simple and fun to play. PSSI is currently being frozen variety of ways to treat a football longing to do and can be a land for business. Not deny various types of businesses associated with this sport can achieve success quickly. Some types of businesses regarding football that can be considered success is like selling merchandise, clothes, shoes, games, watch together as well as in the field of information such as website. Of the few that came the idea to create a website that will accommodate football news, statistics, schedules and watch the game together along with point quiz challenge which is provided on the website.
SISTEM INFORMASI AKUNTANSI PENERIMAAN DAN PENGELUARAN KAS BERBASIS WEB PADA STMIK PRIMAKARA
Authors: Purnama Ni Komang Arix , A.A Istri Ita Paramitha  , Ni Made Estiyanti
Published: April 2023

STMIK Primakara is aInformatics and Computer College which of course cannot be separated from the existence of computerization. Most of the systems that are there are already computerized, including the processing of financial data. Where financial data processing, there is a process of cash receipts and payments like companies in general. This study discusses the development of an information system for cash receipts and disbursements at STMIK Primakara.  This researchwas conducted using the Linear Sequential method.  This research uses the PHP programming language with a code igniter framework.  This research succeeded in developing a cash management information system, especially cash receipts and disbursements at STMIK Primakara. From the results of interviews with users conducted by researchers, responses from those who will use this system are quite positive because it canfacilitate them in the process of managing financial data.
PERANCANGAN USER INTERFACE WEBSITE MENGGUNAKAN METODE USER CENTERED DESIGN (UCD) STUDI KASUS DAO
Authors: Juliana I Ketut Agus Juliana , I Nyoman Yudi Anggara
Published: April 2023

Media promotion is very important in a company. One of the promotional media that is currently often used is the website. DAO is one company that uses the internet as a promotional medium. DAO is a company engaged in the field of cosmetics, especially for women, by relying on natural ingredients and products that are environmentally friendly. DAO uses social media as promotional media, so they want to build a website, but DAO still has difficulty building a website. This study aims to create a DAO website design. This research uses the UCD (User Centered Design) method so that the results obtained can answer consumers' needs for purchasing products digitally through the website, of course in line with DAO's goal of wanting to promote through the website. The result of this research is the design of the DAO website User Interface design so that later it can reach more users and of course increase loyalty.
RANCANG BANGUN SISTEM PELAPORAN KEUANGAN BERBASIS WEB PADA SMK KESEHATAN BALI KHRESNA MEDIKA
Authors: Erich Galang Prasetyawan Putra  , Ni Made Estiyanti  , Eddy Muntina Dharma
Published: April 2023

Bali Khresna Medika Health Vocational School is an institution that is engaged in education at the SMA/K level. The Bali Khresna Medika Health Vocational School is a private school established by individuals through a school committee. Currently, the Bali Khresna Medika Health Vocational School does not yet have a good financial reporting system. This information system is used to exchange information about the school's financial reports every month, especially useful for the finance department (treasurer) to make and determine monthly financial reports. The information system built aims to make it easier to submit monthly school financial reports and save time in making because this reporting system only does data input. The information system implemented will be built using Financial Reporting using In this research report, the researcher uses the Software Development Life Cycle (SDLC) method with the Waterfall development model, using the Mysql Database. While the programming used by the author is PHP (Hypertext Preprocessor) and the end result is a web application that connects to a database that is run on one (single) server. The purpose of this study is to provide convenience in the process of inputting payment and expenditure data, to help speed up the performance of the finance department, to increase accuracy in conducting financial transactions. All transactions will be saved automatically to financial reports which include budgets, cash inflows, cash outflows, general journals, ledgers, income statements, and balance sheets, BOS funds and school inventory data. Suggestions that later this system can be developed by adding or modifying the payroll system feature which will later be able to help the principal and the head of the foundation to see the payroll procedures in this school's financial reporting system.
RANCANG BANGUN SISTEM INFORMASI PEMBELIAN DAN PENJUALAN BERBASIS WEB PADA CV. D’GUNG COLLECTION
Authors: Ni Kadek Sucitrawati  , A.A. Istri Ita Paramitha  , Ni Made Estiyanti
Published: April 2023

This study aims to determine the suitability of the buying and selling system applied in CV. D'Gung Collection. The research method used in this study is the waterfall method, namely the method by means of interviews to collect data as a determinant of the success of a study. In the process of working on the design of this buying and selling system using the PHP programming language and the Laravel framework. The WEB-based buying and selling system that has been designed has been successfully implemented so that it can help the buying and selling process that is carried out every day on CV. D'Gung Collection well.
RANCANG BANGUN SISTEM INFORMASI AKADEMIK WEBSITE UNTUK MADRASAH DINIYAH AWALIYAH UBUDIYAH
Authors: Muhammad Junaedi  , I Gede Putu Krisna Juliharta  , Eka Grana Aristyana Dewi
Published: April 2023

MDA Ubudiyah is an educational institution that focuses on Islamic religious studies. In this place the authors also conducted research. From the sistem currently used, the writer finds the fact that administrative activities there are still paper-based. This is a problem because of frequent data corruption and impractical data retrieval. Therefore the authors offer a solution by creating a website-based information sistem. The development method used in building this system is the Agile software development method. The data collection was carried out by interviewing the Ubudiyah MDA administrators and making observations. The programming language used is the Personal home page (PHP), then the database uses MySQL. The result of this research is the creation of a website-based information sistem to assist administrative activities at MDA Ubudiyah.
ANALISA DAN PERANCANGAN SISTEM INFORMASI PENJUALAN DAN PENGELOLAAN PERSEDIAAN PADA PT ALFAJORES BALI ENAK MENGGUNAKAN METODE WATERFALL
Authors: Ni Putu Nadia Kartika Dewi  , Eddy Muntina Dharma  , A.A. Istri Ita Paramitha
Published: April 2023

PT Alfajores Bali Enak is a shop that sells cakes, cookies, and various other chocolate preparations. Currently, the recording of sales and inventories by PT Alfajores Bali Enak is still done manually. This causes errors in recording sales and inventory, which makes reports inaccurate. With the analysis and design of this information, the system is expected to assist in recording sales transactions and inventory management. This study uses the waterfall method, starting with needs analysis, planning, modeling, and maintenance. The results of this study are in the form of DFD, ERD, Database, and User Interface designs as an overview of the system to be designed. The method of this information system can later assist users in the process of recording transactions so that they become more accurate. This research only reached the design stage, where it is expected to reach the implementation stage in the future.
Evaluation of the mechanical properties of current biliary self-expandable metallic stents: axial and radial force, and axial force zero border
Authors: Yamagata Wataru , Fujisawa Toshio , Sasaki Takashi , Ishibashi Rei , Saito Tomotaka , Yoshida Shuntaro , No Shizuka , Inoue Kouta , Nakai Yousuke , Sasahira Naoki , Isayama Hiroyuki
Published: April 2023

Background/Aims: Mechanical properties (MPs) and axial and radial force (AF and RF) may influence the efficacy and complications of self-expandable metallic stent (SEMS) placement. We measured the MPs of various SEMSs and examined their influence on the SEMS clinical ability.Methods: We evaluated the MPs of 29 types of 10-mm SEMSs. RF was measured using a conventional measurement device. AF was measured using the conventional and new methods, and the correlation between the methods was evaluated.Results: A high correlation in AFs was observed, as measured by the new and conventional manual methods. AF and RF scatterplots divided the SEMSs into three subgroups according to structure: hook-and-cross-type (low AF and RF), cross-type (high AF and low RF), and laser-cut-type (intermediate AF and high RF). The hook-and-cross-type had the largest axial force zero border (>20°), followed by the laser-cut and cross types.Conclusions: MPs were related to stent structure. Hook-and-cross-type SEMSs had a low AF and high axial force zero border and were considered safest because they caused minimal stress on the biliary wall. However, the increase in RF must be overcome.
Gambaran Risiko Post-Traumatic Stress Disorder (PTSD) pada Penyintas COVID-19 di Rumah Sakit Universitas Andalas
Authors:   Andalas University, Wahyuni Sri , Widya Murni Arina ,   Andalas University, Indra Beni ,   Andalas University, Liza Rini Gusya ,   Andalas University, Koerniati Isnindiah ,   Andalas University, Sauma Eldi ,   Andalas University
Published: April 2023

Introduction. The COVID-19 pandemic has a negative impact on life where sufferers can experience emotional problems such as despair, deep sadness, helplessness, anxiety, and depressive symptoms. Especially in hospitalized COVID-19 survivors, there are sequelae in the form of anxiety, depression, and Post-traumatic Stress Disorder (PTSD). PTSD experienced by COVID-19 survivors will affect the patient’s quality of life in the future. This study aimed to assess the risk of PTSD in COVID-19 survivors who had been hospitalized at Andalas University Hospital. Methods. A cross-sectional descriptive study was conducted among COVID-19 survivors aged ≥15 years who had been hospitalized at Andalas University Hospital. Samples were selected by using total sampling method with inclusion criteria included experiencing mild, severe, or critical clinical symptoms during COVID-19 infection, being discharged from Andalas University Hospital for six months or more, and willing to participate in the study by signing an informed consent. Samples who have met the inclusion criteria completed the Bahasa Indonesia version of PCL-5 (PTSD Checklist for DSM-5) questionnaire which has been tested for its validity and reliability. Respondents were categorized as having PTSD risk if the questionnaire results showed a score of ≥23. The collected data were subsequently analyzed using univariate analysis. Results. A total of 75 respondents were included in the study, of which 9.3% (7) were found to be potentially or at risk of PTSD. The group of respondents who were at risk of PTSD was mostly comprised of females, and all of them experienced the four PTSD symptoms (intrusion/re-experiencing, avoidance, negative alterations in cognition and mood, and hyperarousal). The most common trigger that causes PTSD among respondents was the experience of a previous life-threatening traumatic event (71.43%). In addition, the most frequent clinical symptoms of COVID-19 in the PTSD risk group were severe clinical symptoms (71.43%). Conclusions. COVID-19 survivors who have the potential to experience PTSD are predominantly female survivors with severe clinical symptoms, experiencing all four PTSD symptoms, and having a traumatic life-threatening experience during COVID-19 hospitalization.
Performa Diagnostik Global Leadership Initiative on Malnutrition (GLIM) dibandingkan dengan Malnutrition Nutritional Assessment (MNA) dalam Pengkajian Malnutrisi pada Pasien Geriatri di Rawat Inap
Authors:   Program Studi Magister Ilmu Gizi, Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang / Instalasi Gizi dan Produksi Makanan, RSUPN. Dr. Cipto Mangunkusumo, Jakarta, Leoni Astrine Permata , Amelia Wita Rizki ,   Program Studi Magister Ilmu Gizi, Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang / Instalasi Gizi dan Produksi Makanan, RSUPN. Dr. Cipto Mangunkusumo, Jakarta, Laksmi Purwita Wijaya ,   Divisi Geriatri, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Syauqy Ahmad ,   Program Studi Magister Ilmu Gizi, Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Semarang
Published: April 2023

Introduction. As many as 76.6% of patients aged 60 years and above (elderly) are malnourished or at risk of malnutrition based on MNA within the first 48 hours of hospital admission. The prevalence of malnutrition varies widely depending on the population studied, the healthcare setting and the tools used for the assessment. To date, SGA is widely used in the diagnosis of malnutrition for adults and MNA for elderly patients. Recently, experts proposed empirical consensus of GLIM criteria for determining the diagnosis of malnutrition in adults. This study aimed to investigate the diagnostic performance of GLIM criteria as a new consensus in determining the diagnosis of malnutrition in comparison to MNA as a semi-gold standard for nutritional assessment in the elderly. Methods. A cross-sectional study was conducted from January to April 2022 on 103 consecutively recruited elderly patients aged ≥60 years in the Internal Medicine Wards at Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. Results. There were 91.3%, 57.3% and 54.4% malnourished elderly patients upon admission to the hospital, based on GLIM criteria, MNA-SF and MNA-LF, respectively. GLIM has good accuracy compared to both MNA-SF and MNA-LF, as long as the category of malnourished in MNA is a combination of malnutrition and at risk of malnutrition. GLIM had 97.9% sensitivity, 87.5% specificity, AUC 0.93, 98.9% PPV, 77.8% NPV, 7.83 positive LR and 0.02 negative LR towards MNA-SF, and a sensitivity value of 98.9%, specificity 88.9%, AUC 0.94, PPV 98.9%, NPV 88.9%, positive LR 8.91, and negative LR 0.01 towards MNA-LF. Conclusion. GLIM showed good diagnostic accuracy to determine nutritional status in the elderly, especially upon admission to the hospital, so that appropriate early nutritional interventions can be given.
Sensitisasi Alergen Makanan pada Pasien Kolitis Eosinofilik: Laporan Kasus
Authors:   Departemen Ilmu Penyakit Dalam, FKKMK Universitas Gadjah Mada/RSUP Dr. Sardjito, Yogyakarta, Zagoto Agnes Dina Irene Dorithy , Mulya Deshinta Putri ,   Divisi Alergi Imunologi, Departemen Ilmu Penyakit Dalam, FKKMK Universitas Gadjah Mada/RSUP Dr. Sardjito, Yogyakarta, Ratnasari Neneng ,   Divisi Gatroentero-Hepatologi, Departemen Ilmu Penyakit Dalam, FKKMK Universitas Gadjah Mada/RSUP Dr. Sardjito, Yogyakarta
Published: April 2023

Eosinophilic colitis is a very rare disease that can occur in the bimodal population (neonates and young adults) with a prevalence was 2.1/100,000 in overall population and 2.3/100,000 in adults. However, only about 0.1% of cases were diagnosed from biopsy results obtained during colonoscopy. The lack of precise histological criteria for the quantity of eosinophils in the colon mucosa creates a distinct challenge in diagnosing eosinophilic colitis. Eosinophilia in the gastrointestinal tract can be mediated by IgE and non-IgE, but non-IgE tends to be dominant in adults. This report discusses about a case of a 64-year-old male with bloody diarrhea that has been occur for two years. The anamnesis revealed symptoms suggestive of eosinophilic colitis, including complaints of diarrhea with abdominal pain and weight loss. Laboratory tests revealed an increase in peripheral eosinophil count and elevated levels of IgE. A positive skin prick test supported the presence of food allergen sensitization. The endoscopy revealed signs of ulcerative colitis, but the biopsy showed evidence of eosinophilic colitis. Initially, the patient was treated for ulcerative colitis but did not show improvement. Following treatment for eosinophilic colitis, the patient’s clinical status showed improvement. Since eosinophilic colitis can be chronic and recur, an accurate diagnosis and proper management are crucial for achieving complete remission.
An integrated leaf trait analysis of two Paleogene leaf floras
Authors: Müller Christian , Toumoulin Agathe , Böttcher Helen , Roth-Nebelsick Anita , Wappler Torsten , Kunzmann Lutz
Published: April 2023

Objectives

This study presents the Integrated Leaf Trait Analysis (ILTA), a workflow for the combined application of methodologies in leaf trait and insect herbivory analyses on fossil dicot leaf assemblages. The objectives were (1) to record the leaf morphological variability, (2) to describe the herbivory pattern on fossil leaves, (3) to explore relations between leaf morphological trait combination types (TCTs), quantitative leaf traits, and other plant characteristics (e.g., phenology), and (4) to explore relations of leaf traits and insect herbivory.

Material and Methods

The leaves of the early Oligocene floras Seifhennersdorf (Saxony, Germany) and Suletice-Berand (Ústí nad Labem Region, Czech Republic) were analyzed. The TCT approach was used to record the leaf morphological patterns. Metrics based on damage types on leaves were used to describe the kind and extent of insect herbivory. The leaf assemblages were characterized quantitatively (e.g., leaf area and leaf mass per area (LMA)) based on subsamples of 400 leaves per site. Multivariate analyses were performed to explore trait variations.

Results

In Seifhennersdorf, toothed leaves of TCT F from deciduous fossil-species are most frequent. The flora of Suletice-Berand is dominated by evergreen fossil-species, which is reflected by the occurrence of toothed and untoothed leaves with closed secondary venation types (TCTs A or E). Significant differences are observed for mean leaf area and LMA, with larger leaves tending to lower LMAin Seifhennersdorf and smaller leaves tending to higher LMAin Suletice-Berand. The frequency and richness of damage types are significantly higher in Suletice-Berand than in Seifhennersdorf. In Seifhennersdorf, the evidence of damage types is highest on deciduous fossil-species, whereas it is highest on evergreen fossil-species in Suletice-Berand. Overall, insect herbivory tends to be more frequently to occur on toothed leaves (TCTs E, F, and P) that are of low LMA. The frequency, richness, and occurrence of damage types vary among fossil-species with similar phenology and TCT. In general, they are highest on leaves of abundant fossil-species.

Discussion

TCTs reflect the diversity and abundance of leaf architectural types of fossil floras. Differences in TCT proportions and quantitative leaf traits may be consistent with local variations in the proportion of broad-leaved deciduous and evergreen elements in the ecotonal vegetation of the early Oligocene. A correlation between leaf size, LMA,and fossil-species indicates that trait variations are partly dependent on the taxonomic composition. Leaf morphology or TCTs itself cannot explain the difference in insect herbivory on leaves. It is a more complex relationship where leaf morphology, LMA, phenology, and taxonomic affiliation are crucial.
Diseño de mecanismos para agentes con preferencias opuestas
Authors:   ,   Pontificia Universidad Católica de Chile. Instituto de Economía, Jara Nahuelhual Rubén Andrés
Published: April 2023

En esta investigación se analiza un modelo de arbitraje donde dos agentes están interesados en un bien (indivisible). Los agentes reciben información privada, reportan un mensaje relacionado a un planificador social y este último diseña una asignación para distribuir el bien. Mostramos que cuando el conjunto de mensajes que pueden reportar los agentes es de cardinalidad dos, entonces existe una asignación no constante que satisface las restricciones de compatibilidad de incentivos si y solo si la información que reciben los agentes es independiente. Luego, se ilustra que la existencia de asignaciones no constantes pueden aumentar el bienestar social en algunos contextos. Finalmente, demostramos que cuando el conjunto de mensajes que pueden reportar los agentes es de cardinalidad mayor a dos, entonces si las señales de los agentes se distribuyen independientemente existe una asignación no constante que satisface las restricciones de compatibilidad de incentivos. Sin embargo, en este último caso, la existencia de una asignación no constante compatible con incentivos no implica que la información de los agentes sea independiente.
Fast-slow Dynamical Analysis in Harmonic Gear Transmission System with Non-smooth Gear Clearance Condition
Authors: Ding Muchuan
Published: April 2023

Harmonic gear reducer is a new type of mechanical transmission device, which has the advantages of simple structure, small size, high precision, large transmission ratio, and high transmission efficiency, which cannot be realized by ordinary gear transmission devices. Due to the presence of various nonlinear factors in the harmonic gear reducer system, it often exhibits relatively complex dynamical behaviors, which has an adverse effect on the transmission accuracy and transmission efficiency of the system. There are many non-smooth factors in the transmission system, and gear clearance, as one of the common non-smooth factors in the harmonic gear transmission system, has made it difficult to control the relationship between the output angular displacement and the input angular displacement of the system, which reduces the stability and transmission accuracy. Therefore, we establish the dynamics model of the non-smooth harmonic gear transmission system, based on the fast-slow dynamical knowledge and numerical simulation, and analyze the dynamical behaviors of the system under this non-smooth factor. The research shows that when the value of the gear clearance is in a definite zone, the change of the value of the gear clearance will only quantitatively change the dynamic characteristics of the system, but not fundamentally change the motion characteristics of the system. When a smaller torsional stiffness coefficient is adopted, the vibration frequency of the dynamic error response of the system increases obviously, but the corresponding vibration amplitude does not change to a significant extent, which shows that the appropriate torsional stiffness can improve the dynamic response of the system and enhance the ability of the system to absorb external disturbances and resist shocks. In order to make the harmonic reducer satisfy more application situations, the evolution of the dynamical behavior of the system under different external excitations is investigated. When the system is under a light load, it works as a bilateral shock condition. And when it is in the heavy load state, the system switches to the unilateral shock state, and the larger load moment leads to multiple vibration responses in the dynamic error trajectory of the system, which may lead to the phenomenon of speed fluctuation at the output of the system.
The Wound Healing Potential of 2,3 Dimethylquinoxaline Hydrogel in Rat Excisional Wound Model
Authors: Elfadil Abdelbagi , Ali Ahmed S. , Alrabia Mohammad W. , Alsamhan Hamoud , Abdulmajed Hind , Abu Ibrahim Ismail Mohammed , Allibaih Mohammad , Ahmed Khalid Hussein Bakheit
Published: April 2023

Background: 2,3-dimethylquinoxaline (DMQ) is a naturally occurring compound with documented antifungal activity. It showed also good in vitro physicochemical and pharmacokinetic characteristics.

Methods: The wound healing activity of 1% DMQ hydrogel in healthy adult male Wister rats were evaluated using the excision wound model. On day 7, the mean percentage closure of the wound area was determined. The animals were sacrificed on day 7 and skin was isolated for histology research and assessment of some inflammatory & oxidative markers, hydroxyproline and tissue growth factor.

Results and Discussion: Almost complete wound healing was observed after treatment with DMQ 1 % Jell for 7 days. The histological study confirmed marked attenuation of wound-induced histological changes. There was a marked reduction in TNF-α, IL-6 IL-β1 and NF-κB. levels. These data suggest the potential anti-inflammatory effect of DMQ.

Conclusion: DMQ has potential skin wound healing ability likely due to its anti-inflammatory mechanism. Further study is needed to confirm these preliminary findings and explore the molecular mechanism
Mapeamento Tecnológico de Produtos para o Ensino-Aprendizagem de Automação Residencial e Predial (ARP)
Authors: Oliveira Danilo Barros de , Campos Márcio  Inomata
Published: April 2023

Para o setor educacional, é imprescindível que na formação dos estudantes as experiências demonstradas sejam o mais próximo da realidade possível, pois essa similaridade refletirá a competência de cada um. As ferramentas utilizadas para proporcionar habilidades necessárias são chamadas de bancadas didáticas. Dessa forma, foi realizada uma prospecção tecnológica de patentes em bases nacionais e internacionais sobre produtos voltados para o processo de ensino-aprendizagem de automação residencial e predial no contexto educacional. Mundialmente, os resultados demonstraram um domínio do desenvolvimento de produtos/equipamentos controlados por computador que dispõe de funcionalidades para interconectividade e comunicação em rede, já em nível nacional, a concentração do pedido registro de tecnologias está voltada para a comutação de dados em redes de comunicação. No cenário nacional, as oito patentes evidenciaram a carência de empresas nacionais que realizem desenvolvimentos inovadores para o setor de ARP.
Capacitação em Propriedade Intelectual Direcionado a Empreendedores: estudo de caso na Federação das Associações Empresariais de Santa Catarina
Authors: Müller Fernando , Frey Irineu Afonso
Published: April 2023

Este estudo foi desenvolvido com o objetivo de apresentar uma estrutura de ensino destinada à capacitação dos empreendedores da Federação das Associações Empresariais de Santa Catarina (FACISC) no tema Propriedade Intelectual (PI), utilizando pesquisa documental e levantamento como metodologia. Quanto ao escopo, investigou-se diversas propostas pedagógicas que se encontravam em funcionamento no Estado catarinense, considerando desde o ensino técnico até a pós-graduação. Quanto aos instrumentos para coleta de dados, foram utilizados questionários para obter, diretamente junto aos empreendedores da Facisc sediados na região metropolitana de Florianópolis, a percepção destes em relação à importância da PI e quais são as principais demandas de cada setor da economia. Os resultados permitiram a elaboração de uma proposição de estrutura de ensino, destinada a atender especificamente às demandas dos empreendedores da Facisc. O estudo demonstrou a credibilidade que os empreendedores identificam na PI para promoção da inovação e o anseio para obter essa capacitação.
Indicação Geográfica Ilha do Combú para o Produto Chocolate: o primeiro caso de único produtor pessoa física no Brasil
Authors: Ferreira Alexandre Miranda , Bezerra Maria das Graças Ferraz
Published: April 2023

Este artigo teve o objetivo de promover uma reflexão da dinâmica complexa e inédita no Brasil do pedido de Indicação Geográfica para único produtor pessoa física, relacionada à fabricação do chocolate produzido na Ilha do Combú, a ser requerida pela figura nacionalmente conhecida como “Dona Nena”, ribeirinha, filha e moradora da área de proteção ambiental, situada na capital do Estado do Pará. Pelas características excepcionais do tema, foi utilizada a metodologia do tipo exploratória, forma descritiva e abordagem qualitativa, mantendo acesso direto com o órgão registrador, as cópias de processos registrados, os livros, os sites, os periódicos, os trabalhos acadêmicos, a legislação específica e os atos normativos internos do próprio INPI. Os resultados se manifestam pelo compartilhamento da fama e da notoriedade concentradas na única produtora do chocolate, com toda comunidade da Ilha do Combú, o reconhecimento da primeira IG de chocolate da Amazônia e a colaboração técnica e científica pela submissão do pedido inovador no Brasil desse bioproduto da floresta.
Propriedade Intelectual: panorama do desenho industrial entre os microempresários do setor de marcenaria da região metropolitana de Belém
Authors: Teixeira Fábio dos Santos , Rocha Carlos Alberto Machado da
Published: April 2023

Em mercados competitivos, o desenho industrial constitui modalidade de propriedade intelectual de extrema relevância para setores como o da marcenaria. Contudo, surge o questionamento sobre quanto os gestores dessa categoria econômica conhecem essa modalidade de proteção. Diante do exposto, o presente artigo teve como objetivo verificar o nível de conhecimento dos microempresários do setor de marcenaria da Região Metropolitana de Belém sobre propriedade intelectual e em especial sobre desenho industrial. Para isso, foi realizado um estudo exploratório descritivo com enfoque quantitativo, no qual foi possível contar com 10 respondentes dos 24 possíveis. A pesquisa possibilitou observar que, entre os pesquisados, cerca de 80% desconhecem o tema. Dessa forma, nota-se a necessidade de inserção de conhecimentos sobre o assunto entre os microempresários do setor para difundir a temática e sensibilizá-los quanto à importância da proteção das criações geradas.
An Integrated Interdisciplinary Sleep Care Model—The Ultimate Dream Team
Authors: Benjamin Sara E. , Exar Elliott N. , Gamaldo Charlene E.
Published: April 2023

This Viewpoint discusses the need for diverse physicians to manage sleep health.
Severe Hippocampal Atrophy in a Patient With Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy
Authors: Bartels Frederik , Heine Josephine , Finke Carsten
Published: April 2023

This case report describes a patient who presented with headache, fever, quadriparesis, and reduced visual acuity in the left eye and 6 months later presented with persistent quadriparesis and new-onset cognitive deficits.
Association Between Early Prostacyclin Therapy and Extracorporeal Life Support Use in Patients With Congenital Diaphragmatic Hernia
Authors: Ramaraj Akila B. , Rice-Townsend Samuel E. , Foster Carrie L. , Yung Delphine , Jackson Emma O. , Ebanks Ashley H. , Harting Matthew T. , Stark Rebecca A. ,   Congenital Diaphragmatic Hernia Study Group, Lally Kevin , Lally Pam , Boyd Yvette
Published: April 2023

Importance

Prostacyclin (PGI2) is a therapeutic option to treat congenital diaphragmatic hernia (CDH)–associated pulmonary hypertension in neonates. Its use may decrease the need for extracorporeal life support (ECLS).

Objective

To evaluate the association of early PGI2 therapy with ECLS use and outcomes among patients with CDH.

Design, Setting, and Participants

This was a cohort study from the CDH Study Group (CDHSG) registry of patients born from January 2007 to December 2019. Patients were from 88 different tertiary pediatric referral centers worldwide that contributed data to the CDHSG. Patients were included in the study if they were admitted within the first week of life. Propensity score matching was performed using estimated gestational age, birth weight, transfer status, 1-minute and 5-minute Apgar scores, highest and lowest partial pressure of arterial carbon dioxide in the first 24 hours of life, and degree of pulmonary hypertension as covariates to generate a matched cohort of exposed and unexposed patients. Data were analyzed from January 2021 to December 2022.

Exposures

Early PGI2 therapy was defined as initiation of PGI2 within the first week of life. Patients who received ECLS were included in the early PGI2 group if PGI2 was started prior to ECLS.

Main Outcomes and Measures

The primary outcome of the study was the proportion of patients receiving ECLS in the exposed and unexposed groups.

Results

Of 6227 patients who met inclusion criteria (mean [SD] gestational age, 37.4 [2.36] weeks; 2618 [42%] female), 206 (3.3%) received early PGI2 therapy. ECLS was used in 46 of 206 patients who received PGI2 (22.2%) and 1682 of 6021 who did not (27.9%). After propensity score matching, there were 147 patients in the treatment and control groups. Thirty-four patients who received PGI2 (23.3%) and 63 who did not (42.9%) received ECLS. Those who received PGI2 were less likely to receive ECLS (adjusted odds ratio, 0.39; 95% CI, 0.22-0.68) and had shorter mean (SD) duration of ECLS (8.6 [3.73] days vs 12.6 [6.61] days; P < .001), although there was no significant difference in in-hospital mortality.

Conclusions and Relevance

In this study, there was decreased use of ECLS and decreased ECLS duration among patients with CDH who started PGI2 therapy during the first week of life. These results identify a potential advantage of early prostacyclin therapy in this population.
Deconstructing insect herbivore trivial movement in a monoculture and triculture: Limitations of emigration
Authors: Andow David A.
Published: April 2023

Significantly higher population densities of a squash pest beetle, Acalymma vittatum, were observed in a squash monoculture than a triculture of squash, maize, and beans. One hypothesis for such differences is that non‐host plants in the triculture cause the herbivore to move more frequently resulting in higher emigration rates from the tricultures. Plant to plant movement of the beetle was studied in vegetative winter squash to evaluate if differences in components of trivial movement would generate a higher emigration rate from the triculture. Tenure times were shorter on plants in the triculture than on plants in the squash monoculture, there was no movement directionality, movement distances were greater in squash monocultures than in tricultures and were greater during July than August. In the tricultures, plant‐to‐plant transitions were primarily to maize from non‐host plants and to beans or squash from host plants during July, but during August, movement from any plant was primarily to maize. We integrated the values of the movement components from vegetative winter squash into a simple Markov model, and found that during July, emigration was estimated to be faster from the triculture than the monoculture, supporting the hypothesis. However, in August, emigration was estimated to be slower from the triculture. In August, maize plants were tall and, by acting like a fence, greatly reduced the movement distance of beetles. The effect of the differences in emigration rate on beetle population density was greatest for small patches, indicating that emigration may be important only in small‐scale production systems.
Small Molecules, Great Powers: Chemistry of Small Organo‐Chalcogenide Molecules in Rechargeable Li‐Sulfur Batteries
Authors: Zhou Jinqiu , Qian Siyi , Hao Baojiu , Liu Jie , Zhou Xi , Yan Chenglin , Qian Tao
Published: April 2023

Small organic chalcogenides molecules are receiving more attention in conjunction with the development of rechargeable lithium metal batteries (LMBs) especially lithium–sulfur (Li−S) batteries due to their abundant resources, reversible redox, high capacities, tunable structures, unique functional adjustability, and strong interaction with congener polysulfides. In this review, the working principles are generalized of small organo‐chalcogenide molecules in three important parts of batteries: electrolyte, interface, and cathode. First, in terms of regulating kinetics in electrolyte, small organo‐chalcogenide molecules can not only act as redox mediator to accelerate the redox kinetics of sulfur, but also change the inherently slow solid–solid process to form a faster redox pathway, which will bring light to the development of cryogenic Li−S batteries. Second, for interface chemistry, the introduction of small organo‐chalcogenide molecules can construct more elastic and stable anodic single‐SEI or cathodic/anodic dual‐SEI, thus effectively improving the cycling stability of batteries. Third, small organo‐chalcogenide molecules can be used as cathode materials in the form of liquid phase, solid phase, or precursor of polymers. Finally, advised optimizations are proposed about further mechanism deciphering, battery configuration design, machine learning, thereby providing direction to bridge the gap between rational modulation and practical battery implementation for small organo‐chalcogenide molecules.
In Situ Construction of High‐Density Solid Electrolyte Interphase from MOFs for Advanced Zn Metal Anodes
Authors: Xiong Dengyi , Yang Li , Cao Ziwei , Li Fengrong , Deng Wentao , Hu Jiugang , Hou Hongshuai , Zou Guoqiang , Ji Xiaobo
Published: April 2023

Aqueous zinc anode has been re‐evaluated due to the superiority in tackling safety and cost concerns. However, the limited lifespan originating from Zn dendritic and side reactions largely hamper commercial development. Currently, the coating prepared by simple slurry mixing is leaky and ineffectively isolate sulfate and water. Herein, inspired by the DFT calculations and the easy hydrolysis characteristic of MIL‐125 (Ti), an in‐situ grown high‐dense TiO2‐x solid electrolyte interphase (HDSEI) with rich oxygen vacancies is successfully constructed in an aqueous electrolyte, in which the oxygen vacancies not only strengthen the hydrogen binding force thereby inhibiting the hydrogen precipitation by‐reaction, but also reduce the migration energy barrier of zinc ions and enhance the mechanical properties. Profiting from the HDSEI, symmetric Zn cells survive up to remarkable 4200 h at 1 mA cm−2, nearly 42‐times than that of bare Zn anodes. In situ optical microscopy clearly reveals that the in situ grown HDSEI homogenizes the zinc deposition process, while bare zinc without HDSEI shows significant dendrites, confirming the protective nature of HDSEI. Furthermore, full Zn ion capacitors can deliver excellent electrochemical performance, providing a feasible in situ approach to construct HDSEI to implement dendrite‐free metal anodes.
A Sulfur Heterocyclic Quinone Cathode Towards High‐Rate and Long‐Cycle Aqueous Zn‐Organic Batteries
Authors: Sun Qi‐Qi , Sun Tao , Du Jia‐Yi , Li Kai , Xie Hai‐Ming , Huang Gang , Zhang Xin‐Bo
Published: April 2023

Organic materials have attracted much attention in aqueous zinc‐ion batteries (AZIBs) due to their sustainability and structure‐designable, but their further development is hindered by the high solubility, poor conductivity, and low utilization of active groups, resulting in poor cycling stability, terrible rate capability, and low capacity. In order to solve these three major obstacles, a novel organic host, benzo[b]naphtho[2’,3’:5,6][1,4]dithiino[2,3‐i]thianthrene‐5,7,9,14,16,18‐hexone (BNDTH), with abundant electroactive groups and stable extended π‐conjugated structure is synthesized and composited with reduced graphene oxide (RGO) through a solvent exchange composition method to act as the cathode material for AZIBs. The well‐designed BNDTH/RGO composite exhibits a high capacity of 296 mAh g−1 (nearly a full utilization of the active groups), superior rate capability of 120 mAh g−1, and a long lifetime of 58 000 cycles with a capacity retention of 65% at 10 A g−1. Such excellent performance can be attributed to the ingenious structural design of the active molecule, as well as the unique solvent exchange composition strategy that enables effective dispersion of excess charge on the active molecule during discharge/charge process. This work provides important insights for the rational design of organic cathode materials and has significant guidance for realizing ideal high performance in AZIBs.
MXene‐Based Flexible Sensors: Materials, Preparation, and Applications
Authors: Du Tao , Han Xin , Yan Xiuling , Shang Jiangwei , Li Yao , Song Jianbin
Published: April 2023

The rational design and applications of MXene‐based materials have yielded remarkable progress in flexible sensors, including wearable devices, soft robots, and smart medical equipment. The emerging MXene and substrate materials can be precisely engineered to improve the mechanical properties and sensing sensitivity of the sensors, opening up a wider range of application possibilities for MXene‐based sensors. Therefore, a systematic and comprehensive review summarizing the progress of MXene‐based sensor research based on these backgrounds is necessary. First, we discuss the basic structure of MXene materials and introduce the flexible substrate materials for MXene‐based flexible sensors in detail. Then, we also discuss the different preparation methods of MXene‐based sensors, describe the classifications, and highlight the applications of MXene‐based flexible sensors in various scenarios. Finally, we identify the challenges that need to be overcome to accelerate the development of MXene‐based materials in flexible sensing. This review provides a comprehensive and systematic insight into MXene‐based flexible sensors and it is expected that this review will contribute to the development of higher performance MXene‐based flexible sensors.
Recent Progress in Light‐Scattering Porous Polymers and Their Applications
Authors: Yu Shudong , Chen Junchi , Gomard Guillaume , Hölscher Hendrik , Lemmer Uli
Published: April 2023

Conventional inorganic‐nanoparticles‐based scattering systems have dominated many practical applications for years. In contrast, the rise of porous polymers is perceived as a game‐changer due to their low cost, facile preparation, and great abundance. One challenging issue to be tackled is the design and fabrication of porous polymers with light‐scattering properties comparable to those of inorganic nanoparticles. Taking inspiration from nature (e.g., from white beetles Cyphochilus), scientists have achieved remarkable progress in the field of light‐scattering porous polymers and their related applications in recent years. Therefore, here, an up‐to‐date review about this emerging field is provided. This overview covers materials for making porous polymer structures, detailed fabrication methods, and applications benefitting from their tailorable light‐scattering properties. It is envisioned that more bioinspired light‐scattering porous polymers will be made to be potential alternatives of conventional nanoparticles‐based scatterers.