bluuebunny/crossref_metadata_2025 huggingface dataset:
Black Soldier Fly Full-Fat Meal in Atlantic Salmon Nutrition – Part A: Effects on Growth Performance, Feed Utilization, Selected Nutriphysiological Traits and Production Sustainability in Fries
Authors: Mikołajczak Zuzanna , Mazurkiewicz Jan , Rawski Mateusz , Kierończyk Bartosz , Józefiak Agata , Świątkiewicz Sylwester , Józefiak Damian
Published: September 2022

Black soldier fly larva meal (BSFM) application as an innovative feed material has been developed in aquaculture nutrition. However, recent scientific literature is still lacking in the case of insect meal effects on different stages of salmonid fish, and the vast majority of research is focused on farmed Atlantic salmon. Therefore, the holistic approach was undertaken in the cycle of two studies carried out: on fries and pre-smolts. This study aimed to evaluate the effect of fish meal (FM) replacement by full-fat BSFM in Atlantic salmon fry diets on the growth performance, feed utilization, crude protein and crude fat digestibility, somatic indices, histomorphology of intestines, and environmental sustainability. Additionally, pellet quality was assessed. Two experiments were performed on 360 Atlantic salmon fries – each of which lasted 60 days. For the first experiment, 240 individuals were distributed to four experimental groups: six replicates (tanks) per group and 10 fish per tank. For the second experiment, 120 individuals were distributed to four experimental groups: three replicates (tanks) per group and 10 fish per tank were used. The following groups were applied: CON – without the addition of full-fat BSFM and with 39% FM; BSFM5 – with 5% addition of full-fat BSFM and 36.1% FM; BSFM10 – with 10% full-fat BSFM and 33.3% FM; BSFM15 – with 15% addition of full-fat BSFM and 30.3% FM. The present study showed satisfactory results of BSFM inclusion at the levels of 5% and 10% as a replacement for fish meal in feeds for Atlantic salmon fries. No negative effects on growth performance, feed utilization, protein and fat digestibility, or intestinal structure were recorded. Simultaneously, insect meal inclusion in Atlantic salmon diets significantly improved the environmental sustainability of the feed. In the case of BSFM15, decreases in body weight gain, protein lipid efficiency ratio, and lipid efficiency ratio, as well as increases in feed conversion ratio, were observed. Therefore, the use of shares higher than 10% of BSFM in Atlantic salmon fries may not be recommended.
Cellular and neuronal mechanisms that underlie addiction - literature review
Authors: Grzymkowska Maria , Grzywacz Elżbieta , Zadroga Łukasz , Chmielowiec Jolanta , Chwałczyńska Justyna , Błaszczak Katarzyna , Masiak Jolanta , Strońska-Pluta Aleksandra , Grzywacz Anna , Chmielowiec Krzysztof
Published: September 2022

Introduction: Addictive substances act on a number of neurotransmitter systems, and the end result of this action is the activation of the reward system in the brain. The cellular and neuronal mechanisms that underlie addiction have long been searched for. One of such neurotransmitters is dopamine, a catecholamine synthesized in neurons located mainly in the midbrain.

Material and method: The available literature was reviewed on the Pubmed platform and from other sources. The analysis included original studies, reviews.

The aim of the study was to review the literature on the relationship between the DRD2 gene and the occurrence of substance addiction.

Discussion: This work presents several currently discussed biological mechanisms, especially at the molecular and genetic level, involved in the process of addiction to various psychoactive substances. They discovered the brain structures that are most at risk, as well as other neurotransmitter systems and receptor proteins through which they can exert their pathological effects. It has also been established that exposure to psychoactive substances causes significant changes in expression in over 100 genes (including genes for dopaminergic, serotonergic and signaling pathways). The DRD2 receptor (present, among others, in the nucleus accumbens) plays an important role in the reward system, in the transmission of information. The weakening of this conductivity is a significant risk factor for the onset of clinical features that are associated with reward system deficiency syndrome. The expression of the D2 receptor gene may take up to 2 isoforms: short D2S and long D2L.

Conclusions: Further research at the molecular level may result in the modification of psychotherapy and pharmacotherapy in terms of their personalization.
The Economic Legacy of Mega Sporting Events. The Impact of Hosting European Olympic Games on GDP Growth Through Infrastructure Development
Authors: Zawadzki Krystian
Published: September 2022

Introduction.
The positive legacy of the Olympics is often cited by the International Olympic Committee and national organizers. Some scholars, however, question an uncritical approach to an exclusively positive economic legacy. The aim of this study is to evaluate the impact of hosting the Olympics on infrastructure development, with a potential impact on economic growth in the form of Gross Domestic Product (GDP) in three phases of seven Olympic Games organised in Europe in recent years.

Material and methods.
The effect of a particular Olympic period on the GDP was analysed using a difference-in-difference technique in which the difference between each of the analysed seven host countries’ GDPs and those of a reference set of countries was obtained. Each time, as part of the observation, an event time period was distinguished covering all three phases of the event: the preparatory phase, the event phase and the post-event phase.

Results.
For the Winter Olympic Games, no statistically significant positive results are observed in the long term, which may indicate a very limited importance of the economic legacy of these events for potential host countries. In the case of Summer Olympic Games, the positive impact of the organization of these events in the post-event phase is noticeable

Conclusions.
The obtained results confirm the ambiguous impact of Olympic Games on the hosts’ economies and are in line with the attitude of many scholars to an uncritical approach to the only positive legacy of these events.
The Reliability of Venous Sinus Stenosis Using Non Contrast 3D MRV in Prediction of the Diagnosis of Idiopathic Intracranial Hypertension, a Case Control Study
Authors: Fayadh Noor Abbas Hummadi , Al-Waely Noor Kathem Nee'ma , Al-Mosawe Ammar Mosa
Published: September 2022

Idiopathic intracranial hypertension, or shorty IIH, refers to a clinical syndrome in which there is elevated CSF pressure and papilledema in the lack of any focal neurological signs. It is largely a diagnosis of exclusion, but imaging workup is undertaken routinely in order to rule out other pathologies. In this study we tried to evaluate the prevalence of venous sinus abnormalities using the simpler and less invasive non contrast enhanced 3D TOF MRV in group of patients with IIH, using the combined stenosis score, and compare this score with a group of controls, to assess the accuracy of MRV alone as an individual test in predicting the diagnosis of IIH. The study sample included 44 patients and 25 control subjects, following MRV analysis it was found that a combined severity score of cut of value of 4.5 for the combined conduit score (CCS) was associated with 79% sensitivity and 88.6 specificity for the diagnosis of IIH, and a cut off value of 5.5 for the adjusted score method gives a 83% sensitivity and 88.6 % specificity for the diagnosis. MRV is a valuable in the diagnosis of IIH; non contrast 3D MRV is an efficient test and gives valuable diagnostic information.
Geometrial: Development of Educational Digital Game for Combined Two-Dimensional Figure Learning
Authors: Fairuzabadi Ahmad , Tolle Herman , Bachtiar Fitra A , Supianto Ahmad Afif
Published: September 2022

Mathematics is one of the subjects that is often considered difficult and boring for students. This is evidenced by the poor scores obtained by the students. One of the chapters that are considered difficult is the geometry chapter, especially on the topic of combined two-dimensional figures studied by students at the Vocational High School (SMK) level. Spatial skills are needed for students to be able to solve combined two-dimensional figures questions, which to learn will be very difficult without using assisted learning media. While the learning so far is still using the conventional learning approach which is considered boring for students. This is due to the absence of learning media that is fun and can be easily accessed by students. This study tries to present a solution to this problem in the form of a mobile-based educational digital game design that can be accessed by all students. This digital educational game is called Geometry. This study uses Research & Development (R&D) combined with the Agile-Extreme Programming method to develop this educational digital game. Tests were carried out using an expert validation approach to game prototypes. This study uses a questionnaire that adapts the Computer System Usability Questionnaire (CSUQ) to assess the usability aspect of the game system built. Meanwhile, to assess this game from the point of view of educational media, this study used an evaluation questionnaire of material experts and media experts. The development process occurs in 3 iterations of development which includes the ideation, conceptualization, and prototyping stages. The results obtained from the assessment of material experts are 88.9% in the aspect of material suitability, and 85.7% in the suitability aspect of learning evaluation. While the results of the assessment obtained from media experts were 77.1% on the software engineering aspect, 76.3% on the visual design aspect, 80% on the media design aspect, and 77.6% on the system usability aspect (CSUQ).
GÊNESIS E JÓ, O RELATO DA REVELAÇÃO ESPECIAL ANTES DA BÍBLIA
Authors: Da Silva de Souza Flávio
Published: September 2022

Após analisar as histórias relatadas em Gênesis e Jó pode-se perceber o quanto Deus revelou antes da Bíblia ser escrita. Observe que antes da Bíblia ser escrita já havia a revelação do Grande Conflito e da vitória final de Jesus sobre a serpente. O plano da redenção foi anunciado no Éden exemplificado pela morte do cordeiro. Depois explicada a Abraão e exemplificado no quase sacrifício de Isaque. A intercessão pelos outros foi apresentada nas histórias de Abraão e de Jó. A revelação de um Deus que está disposto a dar uma segunda chance pode ser vista na história de Caim, no recomeço da terra após o dilúvio e no final da história de Jó especialmente em relação a seus amigos. A revelação sobre o juízo divino pode ser observada nas histórias de Noé e de Sodoma e Gomorra. A revelação sobre a volta de Jesus foi dada a Enoque. A revelação de que Deus está no controle da história pode ser notada nas histórias de José e de Jó.
O ENSINO RELIGIOSO NA GERAÇÃO TECNOLÓGICA: DESAFIOS E POSSIBILIDADES DA EDUCAÇÃO ADVENTISTA
Authors: Galindo Adolpho Alex Bittencourt , Luiz Torres Milton
Published: September 2022

O presente trabalho objetivou principalmente analisar as implicações das novas mídias e sua consequente mudança na estrutura de pensamento para o ensino religioso cristão. Além disso, investigamos as relações entre a conectividade das mídias atuais e a experiência religiosa do jovem de hoje, avaliamos o papel do professor num contexto de alta disponibilidade de informação e propusemos uma didática religiosa coerente com o aprendizado do indivíduo contemporâneo. Uma vez que a educação cristã tem por base a fé nas Escrituras, faz-se relevante para todo educador no contexto atual tornar essas Escrituras compreensíveis e desejáveis para que seus educandos possam alcançar uma experiência religiosa satisfatória, fazendo do educar algo eficaz. O presente trabalho ambicionou, assim, ponderar acerca de alguns aspectos relevantes à prática docente no ensino religioso.
HÁ (AINDA) ESPAÇO PARA A MODÉSTIA ENTRE OS ADVENTISTAS? UMA ANÁLISE A PARTIR DO TEXTO BÍBLICO, WHITEANO E RECOMENDAÇÕES ECLESIÁSTICAS.
Authors: Barbosa Antônio Ribamar Diniz
Published: September 2022

Ultimamente assuntos relacionados ao estilo de vida não tem despertado muito interesse entre os adventistas do sétimo dia. Embora existam algumas congregações e grupos conservadores preocupados com a questão, além de movimentos dissidentes que polarizam a discussão, pouco se tem escrito e dialogado sobre a modéstia cristã, a reforma pro-saúde, a recreação apropriada, entre outros temas considerados importantes na mentalidade adventista do século passado. Há (ainda) espaço para a modéstia entre os adventistas? Esse artigo visa discutir uma área do estilo de vida adventista (o vestuário). O assunto será abordado desde as perspectivas bíblica (princípios), dos escritos de Ellen White (conselhos) e das recomendações da Igreja (votos e diretrizes). Antes, porém, é necessário reconhecer os esforços da Igreja Adventista do Sétimo Dia na promoção do estilo de vida cristão entre seus 22 milhões de membros.
O NÚMERO DA BESTA: UMA NOVA EXPLICAÇÃO PARA AS VARIANTES 666 E 616 EM APOCALIPSE 13:18
Authors: Luiz Torres Milton
Published: September 2022

O texto de Ap 13:18 é objeto de uma notória divergência textual. A NVI traduz a passagem da seguinte forma: “Aqui há sabedoria. Aquele que tem entendimento calcule o número da besta, pois é número de homem. Seu número é seiscentos e sessenta e seis”. A divergência ocorre justamente na parte final do verso, mais especificamente no número da besta. Os manuscritos mais antigos e importantes trazem o número 666. Entre eles, estão o Códice Sinaítico (do séc. IV) e o Códice Alexandrino (do séc. V), que trazem o número escrito por extenso (hexakosioi hexêkonta hex, “seiscentos e sessenta e seis”). O papiro de Dublin ou p47 (do final do séc. III) também traz o número 666, mas não por extenso. Em vez disso, fornece três letras gregas que representam o número: CHXS, sendo que a letra chi (CH) vale 600, a letra xi (X) vale 60 e o digama (F), mas como um sigma (S) em forma de meia lua (C), vale 6. Quando somamos as centenas, dezenas e unidades, chegamos ao número 666. Os gregos antigos desconheciam o zero e, por essa razão, empregavam 27 letras para representar alfabeticamente os números quando desejavam apresentá-los de forma abreviada. No entanto, o testemunho textual não é unânime em considerar 666 como o número da besta. Um papiro de Oxford, o p115 (do final do séc. III ou início do séc. IV), traz o número 616 de forma abreviada: CHIS, sendo que o chi (CH) representa 600, o iota (I) representa 10 e o digama (S), 6. Além disso, um palimpsesto (C04) do séc. V, conhecido como Ephraemi Rescriptus, traz o número 616 por extenso (hexakosioi deka hex, “seiscentos e dezesseis”). Daí, a necessidade que os entendidos nos manuscritos bíblicos sentem de explicar por que surgiu essa divergência textual.
O PASTOR E OS SEUS RELACIONAMENTOS: A INTEGRAÇÃO DO PASTOR COM A COMUNIDADE
Authors: Fernandes Charles Fabian Costa
Published: September 2022

A influência do pastor deve ir além das quatro linhas da igreja, isso quer dizer que a própria igreja naturalmente exercerá uma influência além dos limites de seu ambiente interno. Esta perspectiva se baseia no ensino bíblico sobre a missão da igreja, a qual envolve alcançar o mundo com o evangelho de uma maneira holística. Desta maneira, o pastor tem a missão de liderar a igreja tendo em vista impactar positivamente a comunidade ao seu redor tanto com a proclamação quanto com a demonstração do evangelho. Isso quer dizer que a missão da igreja abrange igualmente a pregação das boas novas quanto a prática das boas obras. Este foi o método que Jesus utilizou durante o seu ministério terrestre.
Cervical intra and extramedullary hemangioblastoma with associated syringomyelia: A case report and review of the literature
Authors: Colamaria Antonio , Fochi Nicola Pio , Laguado Yasser Andres Dallos , Blagia Maria , Leone Augusto , Carbone Francesco
Published: September 2022

Background:

Spinal hemangioblastoma (HB) is a highly vascularized tumor commonly presenting in the lower thoracic and lumbar segments. It typically causes spinal compression, extensive bleeding, and/or syringomyelia.

Case Description:

A 32-year-old female presented with persistent headaches with a cervical MRI showing an intradural and extradural mass extending from the obex to C2. Following surgical tumor resection, the patient’s symptoms resolved.

Conclusion:

Resection of spinal HB requires direct removal of the tumor mass as the accompanying cystic components typically spontaneously regress.
Regulatory impact assessment and “regulatory guillotine” as institutional forms of business community’s participation in the improvement of regulatory framework in Russia
Authors: Lialikov A. A.
Published: September 2022

The article examines the forms of participation of the business community in the modernization of the regulatory framework in Russia from the perspective of formal procedures provided by the Russian system of public administration. The objects of the study are the institution of regulatory impact assessment (RIA) and the mechanism of “regulatory guillotine”. The aim of the study is to conduct a comparative analysis of the RIA procedure and the mechanism of “regulatory guillotine”. The methodology of the study is based on the methods of comparative and structural-functional analysis of normative legal acts containing the procedures. The article provides a analysis of procedures, presents the legal basis and their functional roles in the system of state decision-making, identifies the objects of influence and stages of procedures, identifies access points and the degree of representation of the business community. The implementation of the procedures contributes to the transparency of the public administration system of Russia, ensuring the development of institutions for the participation of industry experts on the part of the business community in decision-making on issues of regulatory framework. At the same time, the mechanism of the “regulatory guillotine” has a higher degree of influence on the process of approval of draft normative legal acts, but at the same time it is less representative than the regulatory impact assessment procedure.
The effect of distortion of information as a socio-psychological factor of reducing the quality of labor interaction under isolation
Authors: Vakula I. A. , Zvonova E. V. , Scherbakova E. V.
Published: September 2022

The relevance of the problem under study is due to the problems that arise in the conditions of remote forms of labor interaction, as well as the role of the manager in creating an effective communication environment. The purpose of the article is to present the results of a study of the effect of information distortion in labor interaction in isolation, statistical and qualitative analysis of the results. The data obtained allow us to say that in the conditions of remote forms of labor interaction, the lack of direct contact leads to the difficulty of understanding the transmitted information, a decrease in job satisfaction, remission of the levels of well-being, activity and mood, which disrupts the quality of labor communication. The study showed that the subjective assessment of the effectiveness of leadership has a great impact on the state of the participants in the labor interaction. To ensure effective interaction of employees, it is necessary to introduce the rules of remote communication: unified, standardized requirements for communication in remote mode that meet the specifics of a particular enterprise; exclusion from communication of all manifestations of negative emotions; use of all range of available means of communication; emotional leadership of the leader.
The “golden age” of Russian serfdom
Authors: Yakhshiyan O. Yu.
Published: September 2022

The article attempts to show the apogee of Russian serfdom as one of the most significant direct and immediate results of Peter the Great’s transformations. The proprietary (proprietorial) interest of the landed gentry in relation to the local lands and peasants received a previously unthinkable impulse due to Peter’s elevation of the status of estates to patrimonial, as well as the erasure of the legal boundary between serfs and peasants by turning both into “audit souls” during the tax reform. Already in the last years of Peter the Great’s reign, the authorities were inclined to identify the right of landlords to peasants with the right to immovable property in the context of the evolution of serfdom in Russia. The article discusses in detail the practice of distribution by emperors and empresses of lands with peasants into ownership as a reward for special merits. The author analyzed the post-Petrine legislation that expanded the class privileges of the nobility and strengthened their ownership rights in relation to landlords and peasants. Particular attention is paid to the practice of selling landlord peasants without land and with the separation of families. The historical significance of Peter’s and post-Peter’s policies of a sharp strengthening of the ownership (proprietary) rights of nobles to land and peasants in their estates lies primarily in the accumulation of a powerful conflict potential in Russian society for the long term. The “time bomb” laid by Peter I and his immediate successors in the inter-verbal relations of the local nobility and the peasantry dependent on it will explode at the beginning of the twentieth century, and it will give rise to a great peasant revolution in Russia.
Goal-setting and digital competencies as key elements of company development management system based on information and communication technologies
Authors: Veretyokhin A. V.
Published: September 2022

Digitalization is a popular and rather complex direction of modern company development. The article is devoted to justifying the relevance of managerial goal-setting and the need to form digital competencies of employees, as well as their features and provision in the management system of company development based on information and communication technologies. The study uses methods of analysis and synthesis of scientific literature and empirical data. The article summarizes the data of scientific and practical research to identify the main advantages of the company digitalization and the problems of its implementation. The author presents the popular goals of enterprise digital transformation. Using the modern information analysis of competent organizations, the author has constructed the model to justify the goals of the company digital development. The article provides suggestions for the development of digital competencies of company personnel.
Management of commercial activities of a freight forwarding company in market conditions
Authors: Tettsoeva O. A. , Lopareva A. S.
Published: September 2022

At the beginning of 2020, problems arose that will affect the further development of the economy and transport, firstly, the withdrawal of Saudi Arabia and the United Arab Emirates from the OPEC deal, secondly, the fall in the price of Brent oil by more than 30%, thirdly, the outbreak of the coronavirus infection COVID-19, which has largely affected enterprises in all industries. The development of the country’s economy in the global world economy is characterized by volatility and the presence of risks associated with the presence in it of countries with different levels of economic development, economic structure, orientation of the economy, the social structure of society, and the quality of the labor force. The market of road transport services is characterized by a high level of competition in the market. This is due to the following factors: market saturation, the optimal level of tariffs, the volatility of the country’s market economy and the dependence of the transport services market on industrial production, namely on shippers and consignees. Commercial activity can be interpreted as part of entrepreneurial activity related to the sale of goods and services for profit. As the main directions for improving commercial activities, it is planned to integrate marketing and logistics services, which will reduce risks at the stages of movement and storage of products; optimization of business processes of the organization; increasing the company’s rating based on the choice of a reliable carrier; rational selection of a logistics operator.
Determining the prospect for activation of interregional economic interactions in modern conditions
Authors: Gataullin R. F. , Aslaeva S. Sh.
Published: September 2022

The article is devoted to the study of the potential for enhancing interregional cooperation and its main directions. The purpose of the study is to substantiate promising areas of interregional interaction of the Republic of Bashkortostan with neighbouring regions based on an assessment of competitive advantages. In accordance with the goal set, the development levels of individual regions have been determined; the competitive economic activities in them have been evaluated; the specialization of regions, taking into account their competitiveness, as well as the budgetary basis for the development of interregional relations have been identified. The study uses a systematic analysis of economic differences between the regions, identifying the directions of economic reserve flows on the basis of the criterion of alignment of their returns. The differences between the regions in natural conditions and natural resources, in specialization by type of economic activity and by individual types of agricultural products are considered as an economic basis for interregional interaction.
Analysis of risk factors for pelvic organ prolapse in females after hysterectomy
Authors: Soloveva Olga V. , Volkov Valerii G.
Published: September 2022

Aim. To identify risk factors for pelvic organ prolapse in females after hysterectomy.
Materials and methods. A cross-sectional study from August 2019 to October 2021 in women after hysterectomy for benign neoplasms (n=91) analyzed history, outpatient medical record data, and clinical examination findings. Pelvic organ prolapse was assessed using the POP-Q (Pelvic Organ Prolapse Quantification) international classification. All patients were divided into two groups: Group 1 (n=61) included patients with the pelvic organ prolapse; Group 2 (n=30) included patients without the pelvic organ prolapse.
Results. Post-hysterectomy pelvic organ prolapse was observed in 67% (61/91) patients, including grade 1 in 49.2% (30/61), grade 2 in 36.0% (22/61), and grade 3 in 14.8% (9/61). The significant risk factors include obstetric trauma (41 83.7%; odds ratio OR 5.6, 95% confidence interval CI 2.114.8; p=0.00034), age (49 84.5%; OR 19.7, 95% CI 0.5990.831; p=0.00001) and lifestyle associated with weight lifting (32 72.1%; OR 9.8, 95% CI 0.63.9; p=0,00267). No statistically significant differences were observed when comparing the prolapse rate with the presence of connective tissue dysplasia and somatic disorders. Analysis of cumulative risk factors showed significant differences; in Group 1, the mean number of risk factors was 4.61.6 (95% CI 3.26.1), and in Group 2, 2.71.8 (95% CI 2.53.8), t-test value was 6.76, p0.001.
Conclusion. Genital prolapse occurs in more than 1/2 of females after hysterectomy. The most significant risk factors are obstetric trauma, age, and a lifestyle associated with weight lifting. The incidence of pelvic organ prolapse increases when several risk factors are combined.
Pregnancy outcome in uterus didelphys: case report
Authors: Chechulina Olga V. , Davliatshina Liliia R.
Published: September 2022

Most malformations of the female reproductive organs, depending on their features, have a serious impact on reproductive function and the condition of pregnant women. Therefore, all women with uterine and vaginal malformations require counseling in preparation for pregnancy, follow-up during the pregnancy from the early stages, taking into account possible complications, adequate pregnancy management and prevention of complications, as well as fetal monitoring according to gestational age and planning the term and method of delivery.
Pathogenesis mechanisms of endometrial polyps in women of reproductive age: a literature review
Authors: Orazov Mekan R. , Mikhaleva Liudmila M. , Poymanova Olga F. , Mullina Irina A.
Published: September 2022

Endometrial polyp (EP) is a frequent incidental finding during hysteroscopy in asymptomatic patients. To date, the pathogenesis of EPs has not been fully disclosed, which challenges the primary and secondary prevention of EPs and their targeted therapy. It determined the focus of our work. We searched for scientific publications in Cochrane Library, ScienceDirect, PubMed (MEDLINE), eLIBRARY using the keywords "polyps", "endometrial polyps", "pathogenesis", "reproductive age", "recidive" for 20122022. Analysis of the literature data allowed us to conclude that ES pathogenesis most likely involves several mechanisms, both estrogen-mediated (hyperestrogenism, including related to impaired progesterone reception and deficiency) and non-hormonal (inflammatory, immune, genetic factors, neoangiogenesis). Hormonal and non-hormonal factors disturb normal cyclic changes of the endometrium during the menstrual cycle, alter the balance and dynamics of proliferation and apoptosis, and initiate neoangiogenesis that serves as a resolving mechanism of polyposis formation, persistence of ES, and their recurrence after surgical removal. The objective of our study was to analyze and summarize the scientific data available on the mechanisms of ES pathogenesis in women of reproductive age.
Myo-inositol in the treatment of male factor infertility
Authors: Shikh Evgenia V. , Grebenshikova Ludmila Yu. , Zhukova Olga V. , Bagdasaryan Alina A.
Published: September 2022

About 187 million couples worldwide suffer from infertility, with the male factor being diagnosed in 2070% of cases. The main cause of idiopathic infertility has been recognized as the adverse effects of reactive oxygen species. On the one hand, the cellular antioxidant defense is a highly efficient multilevel system; therefore, the pharmacological targets may vary. On the other hand, antioxidant enzymes (superoxide dismutase, catalase, peroxidase) have high activity and specificity, which limits the pharmacological capabilities of direct antioxidants. Indirect methods, such as the normalization of mitochondrial function, are more promising. Mitochondria play a key role in providing energy for sperm motility (one of the main factors of male fertility). Myo-inositol (MI) derivatives involved in cell signaling regulate intracellular Ca2+ ion levels affecting mitochondrial oxidative metabolism and adenosine triphosphate production. Thus, mitochondrial antioxidants are of particular interest for therapeutic strategies. Currently, various routes and regimens of MI use in the treatment of males with oligo-astheno-teratozoospermia (OAT) are being considered in clinical practice. MI-based oral nutraceutical complexes for the treatment of male factor infertility contain both direct and indirect antioxidants. In vitro studies revealed damage to mitochondrial cristae in the sperm intermediate tract in patients with OAT. Experimental studies have demonstrated that mitochondrial structure is restored when sperm are incubated in an MI-containing medium. Clinical studies confirmed that sperm incubation in such an environment leads to increased sperm motility and viability in patients with OAT. Intravaginal administration of MI showed increased total sperm motility and an increased proportion of progressively motile sperm. It is the progressive motility that is considered the best marker for identifying quality and healthy sperm. This type of sperm is usually used for in vitro fertilization techniques. In addition, intravaginal MI administration improved the quality of cervical mucus and reduced its viscosity and crystallization. The effect of intravaginal MI on cervical mucus can be considered as an additional independent factor in increasing fertility.
Prolonged hormonal contraception: current research and practice: A review
Authors: Aganezova Natalia V. , Aganezov Sergey S.
Published: September 2022

This review presents information on demographic processes in Russia and the relevance of highly effective contraception for the prevention of artificial abortion. We present data on the etonogestrel implant (68 mg), an innovative single-stranded subcutaneous implant, a long-acting reversible contraceptive option with high efficacy (Pearl index 0.05) with optimal and typical use of the product. We analyzed the results of the studies that showed a favorable safety profile of the etonogestrel implant with no significant effect on the risks of thrombotic events, metabolic processes, depression incidence, bone mineral density, and characteristics of reproductive function after discontinuation of the drug. The article presents data on possible side effects in the form of changes in the characteristics of menstrual bleeding and a slight increase in body weight, which is comparable with the natural gain in an adult with age. The importance of qualified counseling of patients before and during the use of etonogestrel implants is emphasized.
Short courses of antimicrobial therapy for bacterial vaginosis: the possibilities of modern pharmacology: A review
Authors: Shikh Evgenia V. , Lazareva Natalia B. , Ponomarenko Tatyana M.
Published: September 2022

Bacterial vaginosis is associated with severe infectious and inflammatory diseases and reduces the quality of life in women of reproductive age. Its worldwide prevalence is up to 80%. Thus, the development of new effective and safe methods of antimicrobial therapy becomes an urgent problem.
This article provides a review of current antimicrobial therapies for bacterial vaginosis and evaluates the safety and efficacy of short courses of antimicrobial therapy using combined agents for intravaginal use.
Metaphorical Construction of Marriage among Kenyan Swahili Speakers
Authors:   Kisii University, Kenya, I.N. Opande
Published: September 2022

This study investigates how Kenyans conceptualize marriage. It employs Metaphor Identification Procedure in identifying metaphors on marriage as they are used by Kenyan Swahili speakers. Data for this research is drawn from “Mawaidha na Bi. Msafwari” a programme aired on Citizen TV (a Kenyan TV station) every Saturday evening after the seven o’clock news. The metaphors are then subjected to analysis using The Conceptual Metaphor Theory. The study concludes that marriage is construed in different ways by Kenyan Swahili speakers, it is conceptualized as a house, an eatery, a prison, a school, a journey, a road, a body, a government/ kingdom, a garden, a war, a relationship and as a baby. The various conceptualizations by Kenyans determine their attitudes and general orientation towards marriage.
The transfer of powers and its role in unifying the products of accounting systems and their impact on the quality of accounting information Applied research "in the province of Al- Muthanna."
Authors: Kareem Akeel Dakheel , Jabr Abdul Jabbar Alwan , Hadi Waad
Published: September 2022

Purpose: The research aims at showing the accounting systems applied in the Iraqi environment and knowing the legal framework for transferring powers which is the most prominent of which is the most important provisions of Law No. (19) of 2013.
 
Theoretical Framework: The process of transferring powers from ministries to governorates may be accompanied by many legal, political, administrative and financial issues. In the process of researching administrative and financial matters, the Law No. (19) for the year 2013 which is the last amendment to the process of transferring authority, specified a body called (the supreme coordination committee between the governorates) headed by a president, a council of ministers and the membership of ministers (Municipalities and Public Works, Construction and Housing, Labor and Social Affairs, Education, Health, Planning, Agriculture, Finance, Sports and Youth) and the Minister of State for Provincial Affairs.
 
Design/Methodology/Approach: This paper is divided into four sections. The first section is the research methodology and previous studies, while the second section contains the theoretical framework the concepts of accounting systems in the light of the Iraqi environment. The third section presents the practical aspect of the research. Finally, the most important conclusions and recommendations are shown in the fourth section.
 
Findings: The results show the availability of systems accounting after transfer powers information accounting with high efficiency. Additionally, the effectiveness and the existence of a significant effect relationship between transfer powers and unite products systems accounting.
 
Research Practical& Social implication: Governors and Heads of provincial councils consider transferring powers from the center to local administrations, and in their appropriations allocated in the budget as well as approving the accounts applied in those departments affiliated to the ministries differ in the accounting systems. Some of them use the unified accounting system, and the other uses the central government accounting system. On the other hand, the local administrations use the decentralized government accounting system to achieve the objectives of the research filed.
 
Implications/Originality/Value: Identification the accounting treatments after the process of transferring powers and their impact on the applied accounting systems. The research aims at teasting the main hypothesis that there is a significant relationship between the transfer of powers and quality the information accounting through the mediating role of unification products systems accounting.
Lojistik Maliyetler ve Firma Performansına Etkisi: Borsa İstanbul Gıda Sektöründe Bir Uygulama ( Logistics Costs and Its Effect on Firm Performance: An Application in Borsa Istanbul Food Sector )
Authors: Gümrah Abdurrahman
Published: September 2022

Bu çalışmanın amacı lojistik maliyetlerin firmaların finansal performansı üzerindeki etkisini araştırmaktır. Söz konusu amaç doğrultusunda araştırma kapsamına Borsa İstanbul gıda sektöründe faaliyet gösteren 12 firma dahil edilmiştir.ÇalışmadaVZA ve MOORA yöntemleri birlikte kullanılmıştır. VZA yönteminde girdi değişkenleri olarak lojistik maliyetler kapsamında olan ihracat ve gümrük giderleri kullanılmış; çıktıdeğişkenleriise firmaların performans göstergeleri olarakdeğerlendirilen net satışlar, faaliyetkarı/ zararıve dönemkarı / zararı kalemleri kullanılmıştır.MOORA yönteminin kullanılmasında ise tüm değişkenler bir bütün halinde değerlendirilmiştir.Çalışma sonucunda 2020 ve 2021 yılları itibariyle 8 firma tam etkin çalışmış iken 4 firma tam etkinlik düzeyini yakalayamamıştır.Yine çalışma sonucunda VZA yöntemi ve MOORA yöntemi sonuçlarının birbiriyle paralellik gösterdiği, etkin olan firmaların performans derecelendirmesinin yüksek olduğu buna karşın tam etkinlik düzeyinde çalışamayan işletmelerin performans puanı sıralamasında geride kaldıkları tespit edilmiştir.
Exploring International Post-Graduate Students’ Speaking Experiences in an English as a Medium of Instruction (EMI) Context
Authors: Huiling Ma , Ismail Lilliati
Published: September 2022

This study aims to explore the practice of English as a medium of instruction (EMI) in Malaysia by investigating the experiences of international students enrolled in doctoral programs at the university level. In addition, the study provides an in-depth insight into the students’ attitudes, the challenges they face, and the factors that influence academic English speaking. The authors also examine the implications of enhancing English as a Foreign Language (EFL) within the international post-graduate students’ academic English-speaking experience in the Malaysian EMI context. This study adopted a qualitative approach. Data were collected using semi-structured interviews with 16 international doctoral students enrolled in various doctoral programs at a university in Malaysia. Data were coded and categorized according to themes using the NVIVO 12 software. The results show that there is a variety of challenges faced by the students in academic English speaking in an EMI context. Factors influencing their academic speaking include their past experiences and willingness to communicate. The study also suggests that lecturers should know that code-switching between English and Malay may impact international students’ understanding and involvement in class.
The role of interviewer ethnicity on survey responses: A case study in refugee camps in Bangladesh
Authors: Miles Hannah , Els Christian , Ramizova Cholpon
Published: September 2022

In this paper, we report results of a study conducted in one of the world’s largest refugee camps, the Kutupalong–Balukhali expansion site in Cox’s Bazar, Bangladesh, in early 2021. We compare quantitative results of a survey on Rohingya refugees’ perceptions of humanitarian aid conducted by Bangladeshi and Rohingya interviewers. For 36 out of 40 perception questions, we found a significant difference between the interviewer groups. Rohingya respondents, when interviewed by a member of their own ethnicity, express much lower levels of satisfaction with aid services than those interviewed by Bangladeshi interviewers, are more likely to report rude or abusive behavior, and are less likely to admit to behaviors deemed socially undesirable. Existing literature on ethnicity-of-interviewer effects in public opinion research focuses mainly on the United States and ethnic minorities in Europe, and thus, this study provides new insight into interviewer effects in humanitarian settings. The findings from this study call into question the validity and comparability of surveys conducted in humanitarian settings around the world. For Bangladesh, our findings show the importance of recruiting interviewers from the same ethnic group as respondents in order to elicit honest opinions concerning issues that may be socially sensitive or seen as critical of the aid efforts undertaken on their behalf.
THE ROLE OF INDONESIAN DIPLOMACY IN MANAGING GLOBAL MENTAL HEALTH CASES
Authors: Khairunnisa Brilliant Windy
Published: September 2022

The cases related to mental health become one of the most essential things in international discussions due to the existence of victims in these cases can interfere with the effectiveness of the world's human resources, especially in Indonesia itself. Furthermore, the attention to mental health issues is driven by the existence of the UN's grand plan through the SDGs which includes the concern for mental health. In this case, Indonesian diplomacy has a fairly large role in handling it in light of the fact that a large number of mental health disorders cases occur in Indonesia as well. It will be supported by the existence of national interests and foreign policies issued regarding the concern of mental health issues. This research is based on policy research that aims to determine the role of Indonesia's diplomacy in dealing with global mental health issues, which will be supported by policy recommendations. The research method uses exploratory qualitative with primary data derived from interviews and observation while secondary data derived from literature studies as the source. The results of the study indicate that cases of mental health disorders can interfere with the performance of international relations therefore it requires more practice in the diplomacy world. Indonesia's diplomacy is expected to strengthen communication in international forums in discussing mental health issues especially in its G20 Presidency, as well as provide positive facilities for Indonesian citizens through education including open literacy regarding the importance of mental health.
The Inheritance of Human Traits in the Qur’an Based on the Scientific Interpretation of Zaghlūl Rāghib Muḥammad an-Najjār
Authors: Arib Juhrah M. , Khairiyah Nikmatul , Suryadinata M. , Mokodenseho Sabil
Published: September 2022

This article aims to analyze the inheritance of human traits in the Qur’an, specifically at Surah An-Nisa verse 1, based on the scientific interpretation of Zaghlūl an-Najjār. This study discusses Zaghlūl an-Najjār because he is a geologist and Muslim scholar who has written many books related to science in the Qur’an. The type of this study was qualitative research with a descriptive method. Primary data were obtained through library research related to the works of an-Najjār and interpretations of the Qur’an and hadith, while articles and books were used as secondary data. The employed research approaches were the character approach to study the history, ideas, and socio-historical conditions of Zaghlūl an-Najjār, the exegesis approach to study the content of the Qur’an, and the scientific approach to understand and reveal the meaning of the verses of the Qur’an. This study concludes that the inheritance of human traits in the Q.S. An-Nisa’ verse 1 according to Zaghlūl an-Najjār is in the words “al-nafs al-wāḥidah” (one soul), which means all humans come from the first created creatures, namely Adam. Likewise, the creation of Eve is explained in the words “wa khalaqa minhā zaujahā” (and We created his wife from himself).
A Debate on the Islamic Practice of Pilgrimage to the Grave: Study of the Hadīth on Grave Pilgrimage for Women
Authors: Kamarudin Kamarudin , Mokodenseho Sabil
Published: September 2022

This research aimed to analyze the hadīths and comments of 'ulamā' regarding the prohibition and permissibility of grave visitation by women. In the time of the Prophet Muhammad, the practice of visiting graves was strictly prohibited but later the prohibition was abolished. However, after the Prophet's death, the pros and cons surrounding the law on grave pilgrimage resulted in hostility, as the performers were accused of grave worship and convicted of heresy. Subsequently, the data were analyzed using the library research method with a comparative-compromising approach. The results showed that hadīths on the law of pilgrimage for women were not singular and had birthed several other laws. The admonishment of grave visitation by hadīths editors did not apply to all women because many supported pilgrimages, which made such curses nasākh. It denoted that hadīths prohibiting women from visiting graves were no longer valid, except for the 'illāt, which fulfilled the curse of women. Since different editorials will give rise to varying opinions regarding the grave pilgrimage for women, a compromise between hadīths is necessary to produce an accurate and accommodating legal formulation
PENGARUH PERBEDAAN SUHU TERHADAP LAJU PERTUMBUHAN DAN KELULUSAN HIDUP BENIH IKAN KOI (Cyprinus carpio)
Authors: Sari Susi Puspita , Amelia Jasmine Masyitha , Setiabudi Gede Iwan
Published: September 2022

Ikan hias yang terkenal dikalangan masyarakat umum salah satunya ialah ikan hias jenis Koi. Namun dalam proses budidaya ataupun pembesaran salah satu hal yang sering menjadi perhatian pada saat perkembangan ikan Koi adalah suhu yang dapat mempengaruhi tingkat pertumbuhan dan daya tahan tubuh serta timbulnya berbagai penyakit. Analisis ini dilakukan dengan tujuan untuk mengetahui seberapa besarnya pengaruh suhu terhadap laju perkembangan dan daya tahan hidup ikan Koi. Metode rencana eksplorasi yang digunakan dalam penelitian ini adalah Rancangan Acak Kelompok (RAK) dengan 3 perlakuan, dimana setiap perlakuan tersebut diulang sebanyak 3 kali. Dengan perlakuan yang digunakan adalah P¹ (28?C), P² (30?C) dan P³ (32?C). Hasil penelitian menunjukkan bahwa laju perkembangan yang paling menonjol terdapat pada perlakuan P¹ dengan pertumbuhan panjang 2,9 cm dan pertambahan berat 8 g, kemudian disusul oleh P² dengan pertumbuhan panjang 1,8 cm dan pertambahan berat 5,6 g. dan perkembangan paling sedikit terdapat pada perlakuan P³ dengan pertumbuhan panjang 1,3 cm dan pertambahan berat 3,1 g. Nilai daya tahan hidup ikan Koi selama pemeliharaan di setiap perlakuan rata-rata 100%. Parameter pendukung kualitas air yang didapat adalah pH pada kisaran 6,9-8,5 dan DO berkisaran 5,27-7,76 ml/L. Perbedaan suhu secara signifikan mempengaruhi laju perkembangan dan tidak signifikan terhadap daya tahan hidup ikan Koi.