bluuebunny/crossref_metadata_2025 huggingface dataset:
The BioSCWG Project: Understanding the Trade-Offs in the Process and Thermal Design of Hydrogen and Synthetic Natural Gas Production
Authors: Magdeldin Mohamed , Kohl Thomas , De Blasio Cataldo , Järvinen Mika , Won Park Song , Giudici Reinaldo
Published: October 2016

This article presents a summary of the main findings from a collaborative research project between Aalto University in Finland and partner universities. A comparative process synthesis, modelling and thermal assessment was conducted for the production of Bio-synthetic natural gas (SNG) and hydrogen from supercritical water refining of a lipid extracted algae feedstock integrated with onsite heat and power generation. The developed reactor models for product gas composition, yield and thermal demand were validated and showed conformity with reported experimental results, and the balance of plant units were designed based on established technologies or state-of-the-art pilot operations. The poly-generative cases illustrated the thermo-chemical constraints and design trade-offs presented by key process parameters such as plant organic throughput, supercritical water refining temperature, nature of desirable coproducts, downstream indirect production and heat recovery scenarios. The evaluated cases favoring hydrogen production at 5 wt. % solid content and 600 °C conversion temperature allowed higher gross syngas and CHP production. However, mainly due to the higher utility demands the net syngas production remained lower compared to the cases favoring BioSNG production. The latter case, at 450 °C reactor temperature, 18 wt. % solid content and presence of downstream indirect production recorded 66.5%, 66.2% and 57.2% energetic, fuel-equivalent and exergetic efficiencies respectively.
Animal Autobiography; Or, Narration beyond the Human
Authors: Herman David
Published: October 2016

In engaging with acts of self-narration that cross species lines, creators of animal autobiographies also broach questions about genre, truth status, and the structure as well as the politics of narrative representation. To address these questions, the present article draws not just on scholarship on (animal) autobiography but also on ideas from the fields of linguistic semantics, politeness theory, and discourse analysis, including the “framing and footing” approach that focuses on talk emerging in contexts of face-to-face interaction and that derives most directly from the work of Erving Goffman. On the basis of this research, and using case studies that range from animal riddles to Ceridwen Dovey’s Only the Animals (2014), a collection of life stories posthumously narrated by a variety of nonhuman tellers, I profile autobiographical acts that reach beyond the human as ways of speaking for or in behalf of animal others. Some animal autobiographies correlate with acts of telling for which humans themselves remain the principals as well as authors; their animal animators remain relegated to the role of commenting on human institutions, values, practices, and artifacts. Other examples, however, can be read as co-authored acts of narrating in behalf of equally hybrid (or “humanimal”) principals. These experiments with narration beyond the human afford solidarity-building projections of other creatures’ ways of being-in-the-world—projections that enable a reassessment, in turn, of forms of human being.
The Interacting Axes of Environmental, Health, and Social Justice Cumulative Impacts: A Case Study of the Blueberry River First Nations
Authors: Gislason Maya , Andersen Holly
Published: October 2016

We consider the case of intensive resource extractive projects in the Blueberry River First Nations in Northern British Columbia, Canada, as a case study. Drawing on the parallels between concepts of cumulative environmental and cumulative health impacts, we highlight three axes along which to gauge the effects of intensive extraction projects. These are environmental, health, and social justice axes. Using an intersectional analysis highlights the way in which using individual indicators to measure impact, rather than considering cumulative effects, hides the full extent by which the affected First Nations communities are impacted by intensive extraction projects. We use the case study to contemplate several mechanisms at the intersection of these axes whereby the negative effects of each not only add but also amplify through their interactions. For example, direct impact along the environmental axis indirectly amplifies other health and social justice impacts separately from the direct impacts on those axes. We conclude there is significant work still to be done to use cumulative indicators to study the impacts of extractive industry projects—like liquefied natural gas—on peoples, environments, and health.
Vitamin D Status and Its Consequences for Health in South Africa
Authors: Norval Mary , Coussens Anna , Wilkinson Robert , Bornman Liza , Lucas Robyn , Wright Caradee
Published: October 2016

In this review, reports were retrieved in which vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups with varied skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient [25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A major role for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent, with the dietary contribution being minor. Limited data exist regarding the impact of recent changes in lifestyles on vitamin D status, such as urbanisation. With regard to disease susceptibility, 11 of 22 relevant publications indicated association between low 25(OH)D levels and disease, with deficiency most notably found in individuals with tuberculosis and HIV-1. Information on the relationship between vitamin D receptor variants and ethnicity, disease or treatment response in the South African population groups demonstrated complex interactions between genetics, epigenetics and the environment. Whether vitamin D plays an important role in protection against the range of diseases that currently constitute a large burden on the health services in South Africa requires further investigation. Only then can accurate advice be given about personal sun exposure or dietary vitamin D supplementation.
α6β4 Integrin Genetic Variations (A380T and R1281W) and Breast Cancer Risk in an Argentinian Population
Authors: Acosta Karina , Lorenzini Campos Melina , Etcheverry Susana , Zapata Pedro
Published: October 2016

The α6β4 integrin is composed of the α6 and β4 subunits that are encoded by the ITGα6 and the ITGβ4 genes, respectively. The α6β4 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate the potential role of ITGα6 (A380T) and ITGβ4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGα6 (A380T) single nucleotide polymorphism, a high frequency of heterozygous genotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52–1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGα6) and the risk of developing breast cancer. The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature.
Inducing G2/M Cell Cycle Arrest and Apoptosis through Generation Reactive Oxygen Species (ROS)-Mediated Mitochondria Pathway in HT-29 Cells by Dentatin (DEN) and Dentatin Incorporated in Hydroxypropyl-β-Cyclodextrin (DEN-HPβCD)
Authors: Ashwaq Al-Abboodi , Al-Qubaisi Mothanna , Rasedee Abdullah , Abdul Ahmad , Taufiq-Yap Yun , Yeap Swee
Published: October 2016

Dentatin (DEN), purified from the roots of Clausena excavata Burm f., has poor aqueous solubility that reduces its therapeutic application. The aim of this study was to assess the effects of DEN-HPβCD (hydroxypropyl-β-cyclodextrin) complex as an anticancer agent in HT29 cancer cell line and compare with a crystal DEN in dimethyl sulfoxide (DMSO). The exposure of the cancer cells to DEN or DEN-HPβCD complex leads to cell growth inhibition as determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. To analyze the mechanism, in which DEN or DEN-HPβCD complex causes the death in human colon HT29 cancer cells, was evaluated by the enzyme-linked immunosorbent assay (ELIZA)-based assays for caspase-3, 8, 9, and reactive oxygen species (ROS). The findings showed that an anti-proliferative effect of DEN or DEN-HPβCD complex were via cell cycle arrest at the G2/M phase and eventually induced apoptosis through both mitochondrial and extrinsic pathways. The down-regulation of poly(ADP-ribose) polymerase (PARP) which leaded to apoptosis upon treatment, was investigated by Western-blotting. Hence, complexation between DEN and HPβCD did not diminish or eliminate the effective properties of DEN as anticancer agent. Therefore, it would be possible to resolve the conventional and current issues associated with the development and commercialization of antineoplastic agents in the future.
Structural Interface Forms and Their Involvement in Stabilization of Multidomain Proteins or Protein Complexes
Authors: Dygut Jacek , Kalinowska Barbara , Banach Mateusz , Piwowar Monika , Konieczny Leszek , Roterman Irena
Published: October 2016

The presented analysis concerns the inter-domain and inter-protein interface in protein complexes. We propose extending the traditional understanding of the protein domain as a function of local compactness with an additional criterion which refers to the presence of a well-defined hydrophobic core. Interface areas in selected homodimers vary with respect to their contribution to share as well as individual (domain-specific) hydrophobic cores. The basic definition of a protein domain, i.e., a structural unit characterized by tighter packing than its immediate environment, is extended in order to acknowledge the role of a structured hydrophobic core, which includes the interface area. The hydrophobic properties of interfaces vary depending on the status of interacting domains—In this context we can distinguish: (1) Shared hydrophobic cores (spanning the whole dimer); (2) Individual hydrophobic cores present in each monomer irrespective of whether the dimer contains a shared core. Analysis of interfaces in dystrophin and utrophin indicates the presence of an additional quasi-domain with a prominent hydrophobic core, consisting of fragments contributed by both monomers. In addition, we have also attempted to determine the relationship between the type of interface (as categorized above) and the biological function of each complex. This analysis is entirely based on the fuzzy oil drop model.
Involvement of JNK/NFκB Signaling Pathways in the Lipopolysaccharide-Induced Modulation of Aquaglyceroporin Expression in 3T3-L1 Cells Differentiated into Adipocytes
Authors: Chiadak Jeanne , Arsenijevic Tatjana , Gregoire Francoise , Bolaky Nargis , Delforge Valerie , Perret Jason , Delporte Christine
Published: October 2016

Aquaglyceroporins, belonging to the family of aquaporins (AQPs), are integral plasma membrane proteins permeable to water and glycerol that have emerged as key players in obesity. The aim of this study was to investigate the expression profile of AQPs in undifferentiated and differentiated 3T3-L1 cells and to investigate the changes in expression of aquaglyceroporins in 3T3-L1 cells differentiated into adipocytes and subjected to lipopolysaccharide (LPS) mimicking inflammation occurring during obesity. Furthermore, the study aimed at identifying the signaling cascade involved in the regulation of aquaglyceroporins expression upon LPS stimulation. 3T3-L1 cells were grown as undifferentiated cells (UDC; preadipocytes) or cells differentiated into adipocytes (DC, adipocytes). DC were incubated in the presence or absence of LPS with or without inhibitors of various protein kinases. AQPs mRNA expression levels were measured by real-time quantitative polymerase chain reaction (RT-qPCR). AQP1, AQP2, AQP3, AQP9 and AQP11 mRNA were expressed in both UDC and DC, whereas AQP4, AQP7 and AQP8 mRNA were expressed only in DC. In DC, LPS up-regulated AQP3 mRNA levels (p < 0.05) compared to control; these effects were inhibited by CLI095, SP600125 and BAY11-7082 (p < 0.05). LPS decreased both AQP7 and AQP11 mRNA levels (p < 0.01) in DC as compared to control; this decrease was inhibited by CLI095 and BAY11-7082 (p < 0.05) and additionally by SP00125 for AQP7 (p < 0.05). SB203580 had no effect on LPS-induced AQP3, AQP7 and AQP11 mRNA levels modulations. In conclusion, our results clearly show that many AQPs are expressed in murine 3T3-L1 adipocytes. Moreover, in DCs, LPS led to decreased AQP7 and AQP11 mRNA levels but to increased AQP3 mRNA levels, resulting from the Toll-like receptor 4 (TLR4)-induced activation of JNK and/or NFκB pathway.
Precedents, Patterns and Puzzles: Feminist Reflections on the First Women Lawyers
Authors: Mossman Mary
Published: October 2016

This paper initially examines the historical precedents established by some of the first women who entered the “gentleman’s profession” of law in different jurisdictions, as well as the biographical patterns that shaped some women’s ambitions to enter the legal professions. The paper then uses feminist methods and theories to interpret “puzzles that remain unsolved” about early women lawyers, focusing especially on two issues. One puzzle is the repeated claims on the part of many of these early women lawyers that they were “lawyers”, and not “women lawyers”, even as they experienced exclusionary practices and discrimination on the part of male lawyers and judges—a puzzle that suggests how professional culture required women lawyers to conform to existing patterns in order to succeed. A second puzzle relates to the public voices of early women lawyers, which tended to suppress disappointments, difficulties and discriminatory practices. In this context, feminist theories suggest a need to be attentive to the “silences” in women’s stories, including the stories of the lives of early women lawyers. Moreover, these insights may have continuing relevance for contemporary women lawyers because it is at least arguable that, while there have been changes in women’s experiences, there has been very little transformation in their work status in relation to men.
Incorporation of Rubber Powder as Filler in a New Dry-Hybrid Technology: Rheological and 3D DEM Mastic Performances Evaluation
Authors: Vignali Valeria , Mazzotta Francesco , Sangiorgi Cesare , Simone Andrea , Lantieri Claudio , Dondi Giulio
Published: October 2016

In recent years, the use of crumb rubber as modifier or additive within asphalt concretes has allowed obtaining mixtures able to bind high performances to recovery and reuse of discarded tires. To date, the common technologies that permit the reuse of rubber powder are the wet and dry ones. In this paper, a dry-hybrid technology for the production of Stone Mastic Asphalt mixtures is proposed. It allows the use of the rubber powder as filler, replacing part of the limestone one. Fillers are added and mixed with a high workability bitumen, modified with SBS (styrene-butadiene-styrene) polymer and paraffinic wax. The role of rubber powder and limestone filler within the bituminous mastic has been investigated through two different approaches. The first one is a rheological approach, which comprises a macro-scale laboratory analysis and a micro-scale DEM simulation. The second, instead, is a performance approach at high temperatures, which includes Multiple Stress Creep Recovery tests. The obtained results show that the rubber works as filler and it improves rheological characteristics of the polymer modified bitumen. In particular, it increases stiffness and elasticity at high temperatures and it reduces complex modulus at low temperatures.
MDN-0170, a New Napyradiomycin from Streptomyces sp. Strain CA-271078
Authors: Lacret Rodney , Pérez-Victoria Ignacio , Oves-Costales Daniel , De la Cruz Mercedes , Domingo Elizabeth , Martín Jesús , Díaz Caridad , Vicente Francisca , Genilloud Olga , Reyes Fernando
Published: October 2016

A new napyradiomycin, MDN-0170 (1), was isolated from the culture broth of the marine-derived actinomycete strain CA-271078, together with three known related compounds identified as 4-dehydro-4a-dechloronapyradiomycin A1 (2), napyradiomycin A1 (3) and 3-chloro-6,8-dihydroxy-8-α-lapachone (4). The structure of the new compound was determined using a combination of spectroscopic techniques, including 1D and 2D NMR and electrospray-time of flight mass spectrometry (ESI-TOF MS). The relative configuration of compound 1, which contains two independent stereoclusters, has been established by molecular modelling in combination with nOe and coupling constant analyses. Biosynthetic arguments also allowed us to propose its absolute stereochemistry. The antimicrobial properties of the compounds isolated were evaluated against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Aspergillus fumigatus, and Candida albicans. The potent bioactivity previously reported for compounds 2 and 3 against methicillin-sensitive S. aureus has been extended to methicillin-resistant strains in this report.
Adsorption of Wine Constituents on Functionalized Surfaces
Authors: Mierczynska-Vasilev Agnieszka , Smith Paul
Published: October 2016

The adsorption of macromolecules on solid surfaces is of great importance in the field of nanotechnology, biomaterials, biotechnological, and food processes. In the field of oenology adsorption of wine macromolecules such as polyphenols, polysaccharides, and proteins is much less desirable on membrane materials because of fouling and reduced filtering performance. On the other hand, adsorption of these molecules on processing aids is very beneficial for achieving wine clarity and stability. In this article, the effect of surface chemical functionalities on the adsorption of white, rosé, and red wine constituents was evaluated. Allylamine, acrylic acid, and ethanol were selected as precursors for plasma polymerization in order to generate coatings rich in amine, carboxyl, and hydroxyl chemical groups, respectively. The surface chemical functionalities were characterized by X-ray photoelectron spectroscopy (XPS) and the ability of different surface chemical functionalities to adsorb wine constituents were characterized by quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM). The results demonstrated that the amine and carboxyl modified surfaces encourage adsorption of constituents from white wine. The hydroxyl modified surfaces have the ability to preferentially adsorb rosé wine constituents, whereas red wine adsorbed to the highest extent on acrylic acid surface.
Polymer Nanocomposite Film with Metal Rich Surface Prepared by In Situ Single-Step Formation of Palladium Nanoparticles: An Interesting Way to Combine Specific Functional Properties
Authors: Thompson David , Kranbuehl David , Espuche Eliane
Published: October 2016

This paper presents a continuous single-step route that permits preparation of a thermostable polymer/metal nanocomposite film and to combine different functional properties in a unique material. More precisely, palladium nanoparticles are in situ generated in a polyimide matrix thanks to a designed curing cycle which is applied to a polyamic acid/metal precursor solution cast on a glass plate. A metal-rich surface layer which is strongly bonded to the bulk film is formed in addition to homogeneously dispersed metal nanoparticles. This specific morphology leads to obtaining an optically reflective film. The metal nanoparticles act as gas diffusion barriers for helium, oxygen, and carbon dioxide; they induce a tortuosity effect which allows dividing the gas permeation coefficients by a factor near to 2 with respect to the neat polyimide matrix. Moreover, the ability of the in situ synthesized palladium nanoparticles to entrap hydrogen is evidenced. The nanocomposite film properties can be modulated as a function of the location of the film metal-rich surface with respect to the hydrogen feed. The synthesized nanocomposite could represent a major interest for a wide variety of applications, from specific coatings for aerospace or automotive industry, to catalysis applications or sensors.
Assessment of Perceived Barriers to Herpes Zoster Vaccination among Geriatric Primary Care Providers
Authors: Montag Schafer Katherine , Reidt Shannon
Published: October 2016

The herpes zoster vaccine is recommended for use in adults 60 years of age and older to reduce the incidence and morbidity associated with infection. Its limited uptake has been attributed to logistical barriers, but uncertain efficacy and safety in subsets of this patient population could also be contributing. The purpose of this study was to evaluate the current vaccination practices, barriers to vaccination, knowledge of vaccination reimbursement and strategies to evaluate for insurance coverage among an urban, safety net, teaching hospital, geriatric primary care provider group through a survey administered via paper and online platforms. Survey participants (n = 10) reported lack of availability of the vaccine in their practice settings (6/10), with half of providers (5/10) referring patients to outside pharmacies or to other practice settings (2/10) for vaccine administration. Reimbursement issues and storage requirements were perceived as major barriers by 40% (4/10) of providers, whereas 80% (8/10) of providers reported that concerns about safety and effectiveness of the vaccine were not major barriers to vaccination. Logistical barriers, rather than concerns about safety and effectiveness of the vaccine, were reported as major barriers to vaccination by a significant portion of providers. Lack of availability and reimbursement problems for practice sites allow for gaps in care. Partnership with community and long-term care pharmacies could serve as a possible solution.
Modeling and Hemofiltration Treatment of Acute Inflammation
Authors: Parker Robert , Hogg Justin , Roy Anirban , Kellum John , Rimmelé Thomas , Daun-Gruhn Silvia , Fedorchak Morgan , Valenti Isabella , Federspiel William , Rubin Jonathan , Vodovotz Yoram , Lagoa Claudio , Clermont Gilles
Published: October 2016

The body responds to endotoxins by triggering the acute inflammatory response system to eliminate the threat posed by gram-negative bacteria (endotoxin) and restore health. However, an uncontrolled inflammatory response can lead to tissue damage, organ failure, and ultimately death; this is clinically known as sepsis. Mathematical models of acute inflammatory disease have the potential to guide treatment decisions in critically ill patients. In this work, an 8-state (8-D) differential equation model of the acute inflammatory response system to endotoxin challenge was developed. Endotoxin challenges at 3 and 12 mg/kg were administered to rats, and dynamic cytokine data for interleukin (IL)-6, tumor necrosis factor (TNF), and IL-10 were obtained and used to calibrate the model. Evaluation of competing model structures was performed by analyzing model predictions at 3, 6, and 12 mg/kg endotoxin challenges with respect to experimental data from rats. Subsequently, a model predictive control (MPC) algorithm was synthesized to control a hemoadsorption (HA) device, a blood purification treatment for acute inflammation. A particle filter (PF) algorithm was implemented to estimate the full state vector of the endotoxemic rat based on time series cytokine measurements. Treatment simulations show that: (i) the apparent primary mechanism of HA efficacy is white blood cell (WBC) capture, with cytokine capture a secondary benefit; and (ii) differential filtering of cytokines and WBC does not provide substantial improvement in treatment outcomes vs. existing HA devices.
Secondary Fault Activity of the North Anatolian Fault near Avcilar, Southwest of Istanbul: Evidence from SAR Interferometry Observations
Authors: Diao Faqi , Walter Thomas , Minati Federico , Wang Rongjiang , Costantini Mario , Ergintav Semih , Xiong Xiong , Prats-Iraola Pau
Published: October 2016

Strike-slip faults may be traced along thousands of kilometers, e.g., the San Andreas Fault (USA) or the North Anatolian Fault (Turkey). A closer look at such continental-scale strike faults reveals localized complexities in fault geometry, associated with fault segmentation, secondary faults and a change of related hazards. The North Anatolian Fault displays such complexities nearby the mega city Istanbul, which is a place where earthquake risks are high, but secondary processes are not well understood. In this paper, long-term persistent scatterer interferometry (PSI) analysis of synthetic aperture radar (SAR) data time series was used to precisely identify the surface deformation pattern associated with the faulting complexity at the prominent bend of the North Anatolian Fault near Istanbul city. We elaborate the relevance of local faulting activity and estimate the fault status (slip rate and locking depth) for the first time using satellite SAR interferometry (InSAR) technology. The studied NW-SE-oriented fault on land is subject to strike-slip movement at a mean slip rate of ~5.0 mm/year and a shallow locking depth of <1.0 km and thought to be directly interacting with the main fault branch, with important implications for tectonic coupling. Our results provide the first geodetic evidence on the segmentation of a major crustal fault with a structural complexity and associated multi-hazards near the inhabited regions of Istanbul, with similarities also to other major strike-slip faults that display changes in fault traces and mechanisms.
A Sustainable Performance Assessment Framework for Plastic Film Supply Chain Management from a Chinese Perspective
Authors: Xu Jiuping , Jiang Xianglan , Wu Zhibin
Published: October 2016

Academics’ and practitioners’ interest in sustainable supply chain management has received great concern in recent years. The application of biaxially-oriented polypropylene (BOPP) plastic film has had a significant influence on the economic, environmental and social performance of supply chain management. However, research on the integration of these three sustainable dimensions is still rare in this field. In this paper, we identify sustainability criteria based on a triple bottom line approach (economic benefit, environmental protection and social responsibility) from the supply chain perspective, develop a hybrid multi-criteria decision making framework to evaluate the criteria and select alternatives and apply the proposed approach to a real case study at a focal BOPP plastic film company in China. In the framework, a fuzzy analytical hierarchy process (FAHP) is used to determine the performance criteria weights and a fuzzy technique for order performance by similarity to ideal solution (FTOPSIS) is applied to rank the alternatives. The case study finds that the economic dimension was the most important aspect with environmental second and social third. The results also verify the effectiveness of the proposed framework. This paper develops an effective and systematic approach for decision makers to conduct evaluations and select optimal alternatives for focal plastic film companies.
Simulating the Impact of Economic and Environmental Strategies on Future Urban Growth Scenarios in Ningbo, China
Authors: Liu Yan , Feng Yongjiu
Published: October 2016

Coastal cities in China are challenged by multiple growth paths and strategies related to demands in the housing market, economic growth and eco-system protection. This paper examines the effects of conflicting strategies between economic growth and environmental protection on future urban scenarios in Ningbo, China, through logistic-regression-based cellular automata (termed LogCA) modeling. The LogCA model is calibrated based on the observed urban patterns in 1990 and 2015, and applied to simulate four future scenarios in 2040, including (a) the Norm-scenario, a baseline scenario that maintains the 1990–2015 growth rate; (b) the GDP-scenario, a GDP-oriented growth scenario emphasizing the development in city centers and along economic corridors; (c) the Slow-scenario, a slow-growth scenario considering the potential downward trend of the housing market in China; and (d) the Eco-scenario, a slow-growth scenario emphasizing natural conservation and ecosystem protections. The CA parameters of the Norm- and Slow-scenarios are the same as the calibrated parameters, while the parameters of proximities to economic corridors and natural scenery sites were increased by a factor of 3 for the GDP- and Eco-scenarios, respectively. The Norm- and GDP-scenarios predicted 1950 km2 of new growth for the next 25 years, the Slow-scenario predicted 650 km2, and the Eco-scenario predicted less growth than the Slow-scenario. The locations where the newly built-up area will emerge are significantly different under the four scenarios and the Slow- and Eco-scenarios are preferable to achieve long-term sustainability. The scenarios are not only helpful for exploring sustainable urban development options in China, but also serve as a reference for adjusting the urban planning and land policies.
On the Effect of the Cosmological Expansion on the Gravitational Lensing by a Point Mass
Authors: Piattella Oliver
Published: October 2016

We analyse the effect of the cosmological expansion on the deflection of light caused by a point mass, adopting the McVittie metric as the geometrical description of a point-like lens embedded in an expanding universe. In the case of a generic, non-constant Hubble parameter, H, we derive and approximately solve the null geodesic equations, finding an expression for the bending angle δ, which we expand in powers of the mass-to-closest approach distance ratio and of the impact parameter-to-lens distance ratio. It turns out that the leading order of the aforementioned expansion is the same as the one calculated for the Schwarzschild metric and that cosmological corrections contribute to δ only at sub-dominant orders. We explicitly calculate these cosmological corrections for the case of the H constant and find that they provide a correction of order 10−11 on the lens mass estimate.
Maporal Hantavirus Causes Mild Pathology in Deer Mice (Peromyscus maniculatus)
Authors: McGuire Amanda , Miedema Kaitlyn , Fauver Joseph , Rico Amber , Aboellail Tawfik , Quackenbush Sandra , Hawkinson Ann , Schountz Tony
Published: October 2016

Rodent-borne hantaviruses can cause two human diseases with many pathological similarities: hantavirus cardiopulmonary syndrome (HCPS) in the western hemisphere and hemorrhagic fever with renal syndrome in the eastern hemisphere. Each virus is hosted by specific reservoir species without conspicuous disease. HCPS-causing hantaviruses require animal biosafety level-4 (ABSL-4) containment, which substantially limits experimental research of interactions between the viruses and their reservoir hosts. Maporal virus (MAPV) is a South American hantavirus not known to cause disease in humans, thus it can be manipulated under ABSL-3 conditions. The aim of this study was to develop an ABSL-3 hantavirus infection model using the deer mouse (Peromyscus maniculatus), the natural reservoir host of Sin Nombre virus (SNV), and a virus that is pathogenic in another animal model to examine immune response of a reservoir host species. Deer mice were inoculated with MAPV, and viral RNA was detected in several organs of all deer mice during the 56 day experiment. Infected animals generated both nucleocapsid-specific and neutralizing antibodies. Histopathological lesions were minimal to mild with the peak of the lesions detected at 7–14 days postinfection, mainly in the lungs, heart, and liver. Low to modest levels of cytokine gene expression were detected in spleens and lungs of infected deer mice, and deer mouse primary pulmonary cells generated with endothelial cell growth factors were susceptible to MAPV with viral RNA accumulating in the cellular fraction compared to infected Vero cells. Most features resembled that of SNV infection of deer mice, suggesting this model may be an ABSL-3 surrogate for studying the host response of a New World hantavirus reservoir.
4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression
Authors: Shives Katherine , Massey Aaron , May Nicholas , Morrison Thomas , Beckham J.
Published: October 2016

West Nile virus (WNV) is a (+) sense, single-stranded RNA virus in the Flavivirus genus. WNV RNA possesses an m7GpppNm 5′ cap with 2′-O-methylation that mimics host mRNAs preventing innate immune detection and allowing the virus to translate its RNA genome through the utilization of cap-dependent translation initiation effectors in a wide variety of host species. Our prior work established the requirement of the host mammalian target of rapamycin complex 1 (mTORC1) for optimal WNV growth and protein expression; yet, the roles of the downstream effectors of mTORC1 in WNV translation are unknown. In this study, we utilize gene deletion mutants in the ribosomal protein kinase called S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein (4EBP) pathways downstream of mTORC1 to define the role of mTOR-dependent translation initiation signals in WNV gene expression and growth. We now show that WNV growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E) interaction and eukaryotic initiation factor 4F (eIF4F) complex formation to support viral growth and viral protein expression. We also show that the canonical signals of mTORC1 activation including ribosomal protein s6 (rpS6) and S6K phosphorylation are not required for WNV growth in these same conditions. Our data suggest that the mTORC1/4EBP/eIF4E signaling axis is activated to support the translation of the WNV genome.
THE FIRST PHOTOMETRIC INVESTIGATION OF THE NEGLECTED W-UMa-TYPE BINARY STAR V532 MONOCEROTIS
Authors: He J.-J. , Qian S.-B. , Soonthornthum B.
Published: October 2016

The first two sets of complete charge-coupled device light curves in the B and V bands of the short-period binary system, V532 Mon, are presented. The light curves are analyzed with spot models using the Wilson–Devinney code. V532 Mon is found to be an A-subtype intermediate-contact binary with a degree of contact factor of

, a mass ratio of

, and a cool spot on the primary component. The period changes of the system are investigated by combining newly determined times of light minimum with others published in the literature. We found that the general trend of the observed-calculated

curve shows a downward parabolic variation that corresponds to a long-term decrease in the orbital period at a rate of

−1. The long-term decrease of the orbital period can be explained by mass transfer from the more-massive component to the less massive one. The long-time period decrease, the intermediate-contact configuration, and the astrophysical parameters of the binary system suggest that V532 Mon will evolve into high fill-out, extreme mass-ratio overcontact binaries.
WISEP J060738.65+242953.4: A NEARBY POLE-ON L8 BROWN DWARF WITH RADIO EMISSION
Authors: Gizis John E. , Williams Peter K. G. , Burgasser Adam J. , Libralato Mattia , Nardiello Domenico , Piotto Giampaolo , Bedin Luigi R. , Berger Edo , Paudel Rishi
Published: October 2016

We present a simultaneous, multi-wavelength campaign targeting the nearby (7.2 pc) L8/L9 (optical/near-infrared) dwarf WISEP J060738.65+242953.4 in the mid-infrared, radio, and optical. Spitzer Space Telescope observations show no variability at the 0.2% level over 10 hr each in the 3.6 and 4.5 μm bands. Kepler K2 monitoring over 36 days in Campaign 0 rules out stable periodic signals in the optical with amplitudes greater than 1.5% and periods between 1.5 hr and 2 days. Non-simultaneous Gemini optical spectroscopy detects lithium, constraining this L dwarf to be less than ∼2 Gyr old, but no Balmer emission is observed. The low measured projected rotation velocity (v sin i < 6 km s−1) and lack of variability are very unusual compared to other brown dwarfs, and we argue that this substellar object is likely viewed pole-on. We detect quiescent (non-bursting) radio emission with the Very Large Array. Among radio-detected L and T dwarfs, it has the lowest observed L

ν
and the lowest v sin i. We discuss the implications of a pole-on detection for various proposed radio emission scenarios.
KELVIN–HELMHOLTZ INSTABILITY IN SOLAR CHROMOSPHERIC JETS: THEORY AND OBSERVATION
Authors: Kuridze D. , Zaqarashvili T. V. , Henriques V. , Mathioudakis M. , Keenan F. P. , Hanslmeier A.
Published: October 2016

Using data obtained by the high-resolution CRisp Imaging SpectroPolarimeter instrument on the Swedish 1 m Solar Telescope, we investigate the dynamics and stability of quiet-Sun chromospheric jets observed at the disk center. Small-scale features, such as rapid redshifted and blueshifted excursions, appearing as high-speed jets in the wings of the Hα line, are characterized by short lifetimes and rapid fading without any descending behavior. To study the theoretical aspects of their stability without considering their formation mechanism, we model chromospheric jets as twisted magnetic flux tubes moving along their axis, and use the ideal linear incompressible magnetohydrodynamic approximation to derive the governing dispersion equation. Analytical solutions of the dispersion equation indicate that this type of jet is unstable to Kelvin–Helmholtz instability (KHI), with a very short (few seconds) instability growth time at high upflow speeds. The generated vortices and unresolved turbulent flows associated with the KHI could be observed as a broadening of chromospheric spectral lines. Analysis of the Hα line profiles shows that the detected structures have enhanced line widths with respect to the background. We also investigate the stability of a larger-scale Hα jet that was ejected along the line of sight. Vortex-like features, rapidly developing around the jet’s boundary, are considered as evidence of the KHI. The analysis of the energy equation in the partially ionized plasma shows that ion–neutral collisions may lead to fast heating of the KH vortices over timescales comparable to the lifetime of chromospheric jets.
OBSERVED VARIABILITY AT 1 and 4 μm IN THE Y0 BROWN DWARF WISEP J173835.52+273258.9
Authors: Leggett S. K. , Cushing Michael C. , Hardegree-Ullman Kevin K. , Trucks Jesica L. , Marley M. S. , Morley Caroline V. , Saumon D. , Carey S. J. , Fortney J. J. , Gelino C. R. , Gizis J. E. , Kirkpatrick J. D. , Mace G. N.
Published: October 2016

We have monitored photometrically the Y0 brown dwarf WISEP J173835.52+273258.9 (W1738) at both near- and mid-infrared wavelengths. This ≲1 Gyr old 400 K dwarf is at a distance of 8 pc and has a mass around 5 M
Jupiter. We observed W1738 using two near-infrared filters at λ ≈ 1 μm, Y and J, on Gemini Observatory and two mid-infrared filters at λ ≈ 4 μm, [3.6] and [4.5], on the Spitzer observatory. Twenty-four hours were spent on the source by Spitzer on each of 2013 June 30 and October 30 UT. Between these observations, around 5 hr were spent on the source by Gemini on each of 2013 July 17 and August 23 UT. The mid-infrared light curves show significant evolution between the two observations separated by 4 months. We find that a double sinusoid can be fit to the [4.5] data, where one sinusoid has a period of 6.0 ± 0.1 hr and the other a period of 3.0 ± 0.1 hr. The near-infrared observations suggest variability with a ∼3.0 hr period, although only at a ≲2σ confidence level. We interpret our results as showing that the Y dwarf has a 6.0 ± 0.1 hr rotation period, with one or more large-scale surface features being the source of variability. The peak-to-peak amplitude of the light curve at [4.5] is 3%. The amplitude of the near-infrared variability, if real, may be as high as 5%–30%. Intriguingly, this size of variability and the wavelength dependence can be reproduced by atmospheric models that include patchy KCl and Na2S clouds and associated small changes in surface temperature. The small number of large features, as well as the timescale for evolution of the features, is very similar to what is seen in the atmospheres of the solar system gas giants.
EXTRACTING HOST GALAXY DISPERSION MEASURE AND CONSTRAINING COSMOLOGICAL PARAMETERS USING FAST RADIO BURST DATA
Authors: Yang Yuan-Pei , Zhang Bing
Published: October 2016

The excessive dispersion measures (DMs) and high Galactic latitudes of fast radio bursts (FRBs) hint toward a cosmological origin of these mysterious transients. Methods of using measured DM and redshift z to study cosmology have been proposed, but one needs to assume a certain amount of DM contribution from the host galaxy (

) in order to apply those methods. We introduce a slope parameter

(where

is the observed DM subtracting the Galactic contribution), which can be directly measured when a sample of FRBs have z measured. We show that

can be roughly inferred from β and the mean values,

and

, of the sample. Through Monte Carlo simulations, we show that the mean value of local host galaxy DM,

, along with other cosmological parameters (mass density

in the ΛCDM model, and the IGM portion of the baryon energy density

), can be independently measured through Markov Chain Monte Carlo fitting to the data.
La prégnance de la double échelle de carrière experts/managers : une analyse à travers l’agence des outils de gestion
Authors: Gastaldi Lise , Gilbert Patrick
Published: October 2016

La gestion des experts est un sujet important et d’actualité pour les organisations scientifiques et techniques. Alors que leur performance dépend de leur capacité à attirer, mobiliser et fidéliser des experts, elles rencontrent d’importantes difficultés en la matière. Les experts ressentent un manque de reconnaissance qui entraîne démotivation et turn over. Afin de valoriser et de fidéliser ces experts, un grand nombre d’organisations déploie un outil spécifique : la double échelle de carrière qui crée une filière promotionnelle dédiée aux experts à côté de la voie hiérarchique classique. Cet outil de GRH suscite plusieurs étonnements. Il apparaît comme une innovation RH aux organisations qui l’adoptent aujourd’hui, alors qu’il a été inventé il y a plus de 60 ans. Sa diffusion interroge également quand on considère à quel point la double échelle a été critiquée quant à son incapacité à résoudre la question de la reconnaissance des experts. Enfin, les organisations qui disposent d’une double échelle et en expérimentent les limites ne l’ont pas abandonnée pour autant. Cet article entend élucider le paradoxe de la persistance d’un outil inefficace, paradoxe incompréhensible dans une approche fonctionnaliste. S’inscrivant dans une perspective théorique très différente, les auteurs mobilisent la grille d’analyse de l’agence des outils de gestion (Chiapello & Gilbert, 2016). Sur les sept cas d’organisations de recherche et développement étudiés, les résultats montrent que la double échelle produit des effets – épistémiques, pragmatiques et politiques - qui expliquent sa prégnance, alors même qu’elle ne permet pas d’apporter une solution satisfaisante au problème de reconnaissance des experts. Cette recherche contribue à enrichir la compréhension des outils de gestion pris dans des interactions dynamiques et complexes avec leur environnement organisationnel et institutionnel. Elle donne également des pistes de réflexion aux managers et aux acteurs de la fonction RH en charge des professionnels scientifiques et techniques.
Dans les rouages de la GPEC territoriale : surmonter les tensions pour élaborer une stratégie collaborative
Authors: Mazzilli Ingrid
Published: October 2016

Les organisations sont appelées depuis plusieurs années et dans le cadre des « futurs de la GRH » (Boudreau et Ziskin, 2011), à ouvrir leur périmètre à de nombreux acteurs externes afin de mieux répondre à leurs besoins, mais aussi à ceux de leur territoire d’accueil. Ces logiques collaboratives se sont peu à peu déployées en matière de GRH, donnant naissance à de multiples initiatives en matière de GRH ou de GPEC territoriale (GPECT), considérées ici comme une forme de « partenariats inter-sectoriels ». Les travaux qui les ont étudiées ont pointé leurs enjeux, mais aussi les difficultés lors de leur mise en route. Ce travail propose de poursuivre dans cette voie en s’interrogeant plus particulièrement sur les tensions rencontrées au cours de l’élaboration d’une stratégie collaborative dans le cadre d’une démarche GPECT. L’étude de cas réalisée auprès de la Maison de l’Emploi Ouest Provence revient sur le déploiement d’une démarche GPECT auprès des acteurs de la filière transport et logistique. Elle montre la diversité des tensions rencontrées au cours de ce processus : certaines sont liées au travail collaboratif ou sont spécifiques à la GPECT, d’autres sont relatives au pilotage de la démarche ou plus particulièrement à la présence de la diversité des partenaires. Cette étude met également en évidence le travail réalisé par les pilotes de la démarche pour surmonter ces tensions et aboutir à un équilibre. Plusieurs modalités de résolution des tensions ont été mobilisées, selon la nature de ces tensions et à différents moments de l’élaboration de la stratégie collaborative.
Institutional protocol to standardize the chest drainage system management, from surgery to nursing care, at a regional hospital in northern Paraná
Authors: Morais Amanda Carina Coelho de , Lemos Maurício Medeiros , Marques Vlaudimir Dias , Bandeira César Orlando Peralta
Published: October 2016

The purpose of chest drainage is to allow lung re-expansion and the reestablishment of the subatmospheric pressure in the pleural space. Properly managing the drainage system minimizes procedure-related complications. This prospective observational study evaluated adult patients undergoing water-seal chest drainage, admitted to our hospital and accompanied by residents and tutors, aiming to check their care. One hundred chest drainages were monitored. The average age was 38.8 years old. The average drainage time was 6.7 days. Trauma was the prevalent cause (72%) for the indication of pleural drainage. The obstruction of the system occurred in 6% of the cases; 5% subcutaneous emphysema, 1% infection around the drain; 5% accidental dislodgement of the drain, and in 5% of the patients, there were some complications when removing the drain. Failures in chest drainage technique and management were present, and reflected in some complications that are inherent to the procedure, although it is known that there are intrinsic complications. This study aimed to assess the management of closed chest drainage systems and standardize the care provided in such procedure.