bluuebunny/crossref_metadata_2025 huggingface dataset:
Jogo digital e Autismo: análise de dois ambientes por intermédio dos Affordances de Janet Murray
Authors: Lira Marley de , Gonçalves Caio Fraile , Gonçalves Berenice Santos
Published: May 2022

O Transtorno do Espectro Autista (TEA) é caracterizado como uma síndrome do neurodesenvolvimento que acarreta desvios qualitativos na interação social, comunicação e comportamento. Com isso, as dificuldades que envolvem o bem-estar de uma criança com autismo perpassam diversas áreas da vida, desde sua infância até a fase adulta. Assim, os aspectos relacionados ao autismo devem ser considerados na idealização de ferramentas de apoio para auxílio educacional e terapêutico de crianças com autismo. Neste cenário, tem crescido o uso dos jogos digitais como estratégia de apoio ao desenvolvimento de habilidades e funcionalidades no acompanhamento educacional e terapêutico de crianças com autismo. A partir disto, este estudo se propôs a analisar o jogo digital Minecraft e o blog Autcraft, relativo ao público com autismo que utilizam o jogo digital e o blog citados, com o propósito de identificar fragilidades e potencialidades por intermédio do grid dos quatro Affordances digitais de Janet Murray, que os apresentam como propriedades de Design de Interação para potencializar a capacidade expressiva de artefatos digitais. A análise consistiu na observação direta a partir do contato dos pesquisadores com os dois ambientes delimitados para a análise, identificando os aspectos percebidos das duas interfaces utilizando a ferramenta de análise conhecida como “Grid das 4 Affordances digitais” da autora mencionada. Por fim, destaca-se que os dois ambientes são complementares, visto que apresentam aspectos que contemplam os Affordances digitais em maior e menor proporção, evidenciando as possibilidades de desempenho em apoio à educação e saúde promovendo suporte para crianças com autismo.
Jogos Sérios e Elementos de Jogos na Promoção de Engajamento em Contextos de Telerreabilitação de Pacientes
Authors: Souza Carlos Henrique Rorato , Oliveira Daniel Machado de , Berretta Luciana de Oliveira , Carvalho Sérgio Teixeira de
Published: May 2022

Os jogos têm várias aplicações em contextos que não envolvem apenas entretenimento. Em contextos de telerreabilitação de pacientes, o engajamento promovido pelos elementos que circundam o universo dos jogos pode ser utilizado para motivar o paciente a realizar exercícios muitas vezes considerados enfadonhos e repetitivos. Nesse sentido, este trabalho apresenta os detalhes do desenvolvimento de um exergame distribuído que visa auxiliar nas sessões de telerreabilitação, melhorando o engajamento com o paciente. Ele foi construído no motor de jogo Unreal Engine 4. São detalhadas as etapas envolvidas no processo de construção, bem como a utilização de elementos do jogo para promover um maior engajamento do paciente/jogador. Um processo de avaliação pelo Método Delphi ajudou a validar a eficácia do jogo.
Um game para auxiliar no aprendizado do esqueleto humano
Authors: Santiago Phellipe Caetano , Chagas João Vitor de Souza , Conci Aura
Published: May 2022

Esse trabalho apresenta um protótipo de uma implementação para smartphone de um game para o ensino da anatomia óssea humana. O sistema tem interface intuitiva e simples, necessitado apenas de um celular com o sistema operacional compatível e câmera. A interação do usuário com o mesmo e feita pela analise de seus gestos. O questionário foi aplicado a um conjunto de usuários mostrando a efetividade da aplicação para o aprendiz. Esperamos logo ter um feedback de seus professores no ensino e ampliar o jogo com fases ainda mais interessantes, usando sugestões da comunidade interessada.
Aplicação de jogos digitais para ensino e aprendizado de cuidados com saúde
Authors: Rodrigues Andrea Carla Vargas , Cidade Iran de Alvarenga , Vasconcelos André Carlos Teixeira , Quadros João Roberto de Toledo
Published: May 2022

Em vista do crescente uso de jogos como recurso educacional, utilizando metodologias pedagógicas adaptadas, e porque a geração atual está mais conectada à indústria de jogos; ações e atividades que requerem uma mudança nos aspectos culturais podem ser introduzidas através de jogos. Uma das áreas que utiliza este recurso é a área da saúde. Aproveitando o problema mundial criado pela pandemia da COVID19, para reduzir a reatividade das ações de profilaxia que estão sendo aplicadas, foi desenvolvido um jogo, seguindo a abordagem de gamificação com didática interativa, para ajudar a assimilar a compreensão e aplicação da profilaxia padrão adotada. A abordagem pedagógica do jogo desenvolvido propõe trazer a doutrina da prevenção de doenças de forma didática e lúdica, apresentando os processos protocolares de saúde, através de um jogo dirigido à pessoa comum, com cenários que fazem parte de sua vida diária. Desta forma, o jogo se torna mais aderente para que as pessoas saibam como cuidar de si mesmas e evitar que sejam contaminadas ou transmitam o vírus. Além disto, o método de desenvolvimento pode servir para futuras necessidades de ensino de profilaxia que se fizerem necessárias.
Desenvolvimento de serious game para crianças portadoras de anemia falciforme
Authors: de Santana Lucas Pereira , Caitano Débora Ayane N. , do Vale Filipe Fiusa , Neto Daniel de Santana , da Silva Samuel Santos , Santos Renata Maria de Souza , de Santana Fernanda Castelo B. , Luz Igo Amauri dos Santos
Published: May 2022

A Anemia Falciforme é uma doença hereditária caracterizada pela malformação dos glóbulos vermelhos. Embora tenha alta incidência no Brasil, poucos esforços são feitos na educação preventiva de crianças com essa doença. Este estudo tem como objetivo desenvolver um jogo 2D que sensibilize crianças com Anemia Falciforme para o autocuidado de forma a influenciar positivamente em sua qualidade de vida. Com base na abordagem clássica de design de jogo digital, a equipe multidisciplinar executou o projeto de acordo com as seguintes etapas: concepção, pré-produção, prototipação e produção. Como resultado deste estudo, temos o Game Design Canvas do jogo e o jogo executável 2D para a plataforma Android.
Jogos e Transtorno do Espectro Autista (TEA): uma análise do que tem sido publicado nos anais da SBGAMES (2010-2020)
Authors: Dias Rafaela Cruz , Lefebvre Rodrigo Barcelos , de Oliveira Roberto Dalmo V. Lima
Published: May 2022

O Transtorno do Espectro Autista (TEA), classificado como um Transtorno de Neurodesenvolvimento, envolve manifestações relacionadas à interação social, comunicação e linguagem e comportamentos estereotipados. Este trabalho tem como objetivo a sintetização, a partir de uma revisão bibliográfica das pesquisas sobre jogos e TEA publicadas nos anais da SBGames, de 2010 a 2020. A seleção e análise dos dados foram feitas de acordo com os parâmetros de uma revisão sistemática, visando a classificação e entendimento das perspectivas abordadas nos trabalhos. Essa análise demonstrou diferentes abordagens tanto com relação às manifestações do TEA, quanto na forma de elaboração e temas envolvendo os jogos trabalhados. Além disso, metodologias específicas para o tratamento do TEA, como a ABA, TEACCH e PECS foram utilizadas em parte considerável dos trabalhos.
Jogo é para o que se move: Design como favorecedor da construção de espaços colaborativos e dialógicos de ensino-aprendizagem por meio da criação e adaptação de jogos analógicos
Authors: Dias Cynthia Macedo , Farbiarz Jackeline Lima
Published: May 2022

Este artigo apresenta a tese de doutorado “Jogo é para o que se move: Design como favorecedor da construção de espaços colaborativos e dialógicos de ensino-aprendizagem por meio da criação e adaptação de jogos analógicos”, defendida no Programa de Pós-graduação em Design do Departamento de Artes e Design da PUC-Rio. A tese buscou pesquisar como a criação / adaptação de jogos analógicos na escola mediada pelo Design pode favorecer a construção de espaços colaborativos e dialógicos de ensino-aprendizagem. Para tal, baseou-se em revisão bibliográfica; análise de artigos e de jogos analógicos; mapeamento de experiências de professores que desenvolveram atividades de adaptação e/ou criação de jogos analógicos com estudantes; e mapeamento dos posicionamentos de professores e alunos participantes de proposta de criação de jogos em uma escola de Ensino Médio Técnico. Constatamos a importância de competências do Design e de seus métodos como suporte ao trabalho dos professores e a necessidade de se assumir uma atitude dialógica nessas experiências.
Balancing Pedagogy, Emotions and Game Design in Serious Game Development
Authors: Natucci Gabriel C. , Borges Marcos A. F.
Published: May 2022

Serious games and game-based learning approaches have been shown to provide effective learning outcomes in various contexts. However, the design of games with educational purposes is not an easy feat, since many aspects must be considered during development: pedagogical theories, learning mechanics, game elements, player experience, and affective, cognitive and behavioral outcomes. The balance of these aspects is one of the greatest challenges both game designers and educators must face in the next few years, especially considering the impact of previously neglected areas, such as the importance of emotions in learning. This work outlines the complexities of this challenge and suggests possible solutions based on high-impact studies to create quality games that excel both in player experience and learning.
Promoção da Autonomia dos Atores no Processo de Criação de Jogos Digitais Educacionais
Authors: Araújo Rafael D. , Gasparini Isabela
Published: May 2022

O processo de desenvolvimento de jogos digitais educacionais apresenta diversos desafios. A autoria é um deles, intensificada pela infinidade de domínios de aplicação e no consumo de tempo para programar e disponibilizar cada novo jogo. Dessa forma, existe uma lacuna entre o processo criativo dos jogos digitais educacionais e seu desenvolvimento, causando uma ruptura de escala entre a necessidade da criação desses artefatos para fins específicos e seu efetivo uso. Assim, este trabalho discute o desafio de criar arquiteturas e ecossistemas de software para proporcionar uma maior autonomia na construção de jogos digitais educacionais por diferentes atores, mantendo características de softwares educacionais e, ainda, para permitir o acompanhamento do processo de aprendizagem. Para isso, o artigo discute este desafio do ponto de vista dos professores, estudantes e gestores, e seus diferentes papéis nesse contexto.
No.Voice
Authors: Batista Danilo Lemos
Published: May 2022

Este short paper tem o objetivo de apresentar o jogo não digital No.Voice. Desenvolvido durante uma Game JAM com tema Acessibilidade, foi o resultado de uma das atividades da Semana Aracaju Acessível de 2018. Nele os jogadores precisam encenar um diálogo sem emitir sons, usando gestos e expressões faciais, para que suas equipes identifiquem objeto, lugar, emoção e assunto descritos nas fichas. Além do entretenimento, o jogo pode ser usado para desenvolver habilidades relacionados à comunicação para pessoas com deficiência auditiva, transtorno do espectro do autismo, transtornos de linguagem e pessoas sem deficiência ou com desenvolvimento neurológico típico.
Perception of Computer Graphics Characters in Groups with Skin Color Diversity
Authors: Araujo Victor Flávio de Andrade , Schaffer Diogo Hartmann Muller , Costa Angelo Brandelli , Musse Soraia Raupp
Published: May 2022

This paper aims to assess the human perception of groups about charisma, comfort and realism in relation to black and white skin colors of characters created with Computer Graphics (CG) in different media, such as movies, games, animations, simulations, among others. We created a form that contained images of groups of CG characters with black and white skin colors, and asked participants to rate perceived comfort, charisma and realism. After that, we compared these results with data collected from related work. The results indicated that people can feel comfortable, and observe charisma similarly to CG characters with black and white skin colors.
Hepatitis A Chronic Immunity: A Population-Based Seroprevalence Study in Fars Province, Southern Iran
Authors: Honarvar Behnam , Zahedroozegar Mohammad Hassan , Asmarian Naeimehossadat , Zahedroozegar Ali , Saber Khadijeh , B Lankarani Kamran
Published: May 2022

Background: Hepatitis A virus (HAV), the most common cause of acute viral hepatitis, afflicts millions of people and causes the loss of thousands of lives annually. Objectives: This study aimed to detect the seroprevalence of anti-HAV IgG in Fars province, Iran. Methods: This cross-sectional study was conducted using multi-stage cluster random sampling from 12 cities and 24 villages. All age groups, excluding infants (≤ 1-year-old), were included in this study. A valid checklist consisting of demographic and sanitation items and questions about the transmission routes of HAV were filled out for each individual. In the case of children, interviews were performed with one of the parents. Furthermore, anti-HAV IgG was detected by enzyme-linked immunosorbent assay (Dia.pro kits, Italy) on 3 cc of the blood sample of each participant. Data were analyzed using univariate and multivariate (binary logistic regression) tests by SPSS. We applied both World Health Organization (WHO) and age at mid-point of population immunity (AMPI) protocols for HAV endemicity classification. In addition, the geographical variation of hepatitis A chronic immunity was analyzed by the Bayesian spatial model. OpenBUGS program was used to estimate parameters, and ArcGIS was used to display the results on a map. Results: A total of 547 participants with an age range of 1 - 82 years, mean age of 33.07 ± 15.1 years, and female to male ratio of 1.1 were studied. Overall, 380 (69.5%) individuals had anti-HAV IgG, and 124 of 282 (44%) adults ≤ 30 years old had HAV immunity. AMPI was 25 years old. Being married (OR = 10.7), non-Fars ethnicity (OR = 2.8), knowledgeable about HAV (OR = 2.2), and employed (OR = 1.7) were the strongest determinants of anti-HAV seropositivity. Southern cities of Fars province, which have a hot climate, had the highest prevalence of HAV immunity. Conclusions: Fars province is a very low and intermediate HAV endemic area based on WHO and AMPI protocols, respectively. High-risk groups, such as patients with chronic liver diseases or coagulopathy, travelers to highly-endemic areas, intravenous drug abusers, and homosexuals, should be given priority in the HAV vaccination program. However, the strategy of HAV vaccination should be tailored to subsequent cost-effectiveness studies and national HAV vaccination strategy.
Can Infusion of Lidocaine During Breast Cancer Surgery Promote Higher In-vitro Apoptosis in Comparison with Fentanyl?
Authors: Shirian Sadegh , Samsami Majid , Abtahi Dariush , Mirkheshti Alireza , Zangoue Malihe , Shakeri Alireza , Mohammadian Soudabeh , Memary Elham
Published: May 2022

Background: Although several numbers of the common anesthetic drugs are frequently used in breast cancer (BC) surgery, their possible effects on the behavior of cancer cells are still unknown. Objectives: The main objective of the present study was to examine the effect of administered lidocaine versus fentanyl during BC surgery on the apoptosis index of BC cells in-vitro. Methods: Patients with BC with the same grade of cancer and American Society of Anesthesiologists (ASA) score I–III, who underwent surgery were randomly divided into 2 groups of lidocaine and fentanyl infusion based on the analgesic drugs they received. Blood samples were drawn before and after the surgery and then cells from the BC cell line (MCF-7) were exposed to them at 24, 48, and 72 hours post-culture. Flow cytometry was performed to measure the mean percentage of apoptosis index; To investigate the cells’ viability, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was also applied. Results: Sixty patients were enrolled. Quantitative cell death analysis revealed that the proportion of apoptotic cells in both lidocaine and fentanyl groups significantly increased when the cells were treated with post-operation sera compared to pre-operation sera exposure at various time intervals. In both groups, intra-group cell death analysis showed that there was not any statistically significant difference among the cultured cells exposed to pre-operation sera at various interval times (P < 0.001) with respect to apoptosis and cell viability. Conclusions: The study findings proposed that lidocaine infusion can reach the apoptosis index of BC cells in-vitro, as much as that fentanyl did; and both drugs had significant effects.
Women, Water, and Walkways: Preliminary Findings from the Jezreel Expedition in Light of Biblical and Archaeo-Ethnographic Evidence
Authors: Appler Deborah , Bidmear Julye , Love Marilyn
Published: May 2022

In the Hebrew Bible, young women draw water and gain blessings and husbands (Gen 21:14–20; 24:10–27; 29:1–11; Exodus 2:15–19). Yet, the meeting at the well was more than a biblical betrothal type-scene. Rather, it was a gender-specific and time-consuming task that was es- sential to the household and community. Cross-cultural ethnographic data from nineteenth and early twentieth century Levant also depict women as the water carriers. Exploring the textual mentions of water-carrying in the Hebrew Bible, clues from ancient iconography, nineteenth- and early twentieth- century representations of Middle Eastern women, and an experiment conducted at Tel Jezreel, this paper evaluates the amount of time devoted to carry water, methods of conveyance, and types of vessel employed in Iron Age Israel.
In the Land and in the Dirt The Value of Field-School Experience for Divinity School Students
Authors: Cartledge Tony W.
Published: May 2022

This essay is a testimony on the impact of active participation in an archaeological field school such as the Jezreel Expedition on divinity school or seminary students and volunteers.
Gone to the Dogs Zer‘in through Western Eyes
Authors: Ebeling Jennie
Published: May 2022

Many western travelers to Palestine in the nineteenth century visited Zer‘in, the site of ancient Jezreel, on their tours to sites of biblical significance. Although dozens of published accounts by Chris- tian pilgrims and other visitors record information about the contemporary Arab settlement and its inhabitants, the focus of these accounts is the ancient remains, or, more accurately, the lack thereof. Trav- elers made note of decorated sarcophagi lying at the entrance to the village and a “tower” standing at its center, but they drew a stark contrast between the imagined splendor of Ahab and Jezebel’s Jezreel and the general squalor and ruin they witnessed at Zer‘in. This survey reveals how nineteenth-century trav- elers experienced the site through the lens of the biblical stories set at Jezreel, particularly those about Jezebel, and explained the conditions at the site on the biblical curse placed on Ahab and his evil queen.
Naboth and Moshele Reading a Biblical Story in Light of the Construction of the Memory of a Modern Martyr
Authors: Guillame Phillippe , Rogel Menachem
Published: May 2022

Jezreel is the scene of two murders, that of biblical Naboth and that of kibbutznik Moshele Orion. Slicing the biblical story and one particular episode of the Israeli-Palestinian struggle in the 1950s, this essay explores the formation of social memory. The fate of the two heroes may help probe deeper the formation of the Naboth tradition and how the memory of Moshele may evolve depending on local political developments.
A Fourth-Century BCE Chian Stamped Amphora Toe from Tel Akko, Israel
Authors: Killebrew Ann E. , Finkielsztejn Gerald , Shalev Yiftah , Skinner Jane C. , Stefanaki Vassiliki E.
Published: May 2022

A Chian Straight-Neck amphora with an unusual stamped toe, dating to the third quarter of the fourth century BCE, was excavated at Tel Akko, Israel, in 2015. The stamp impression depicts the profile of a sitting sphinx facing left, with an amphora positioned in front of it. What makes this impres- sion unique is its location on the toe of the vessel rather than the usual placement on the rim, neck, or shoulders of the amphora. Very similar seated sphinxes facing amphoras appear on fourth-century BCE silver Chian coins. We suggest the contemporaneity of this motif on both Chian amphora stamps and coins indicates a centralized administrative control of measures within a common political-economic context.
Of Shekels and Shackles A Wadi Sorek Romance ( Judges 16)
Authors: Sasson Jack M.
Published: May 2022

This essay focuses on Samson in Delilah’s chamber (Judges 16). It explores the use of love charms in antiquity to clarify the bonds between the two major characters. It also offers an alterna- tive understanding for why Samson gave in to Delilah’s serial insistence that he reveals the secret of his strength.
The Case of the Enigmatic “Cypro-Phoenician” Juglets in Moab
Authors: Steiner Margreet L.
Published: May 2022

In several Iron Age tombs in ancient Moab in Transjordan, large quantities of small painted juglets have been found. In excavation reports these juglets are commonly called “Cypro-Phoenician” and are seen as products of the interregional trade over the King’s Highway and as direct proof of con- tacts with Phoenicia. However, the Jordanian juglets differ significantly from those found in either Cy- prus or Phoenicia. This analysis of a number of the juglets from Mudayna, Sahab, and Dhiban show that these luxury items were most likely locally made. In the emerging state of Moab they may have been used as markers of status and identity by the elites buried in the tombs.
We Play Every Day
Authors: Williams Simone Donnette , Del Rio Lora
Published: May 2022

While imaginative play and sensory-stimulating activities are credited as benefitting childhood development, a growing body of literature suggests play is beneficial for adult development in terms of promoting emotional and physical well-being, facilitating inclusive social interactions, increasing productivity, and improving learning. Experts in library and information science and higher education are examining how best to implement play into academic libraries to better understand how play can have tangible outcomes on community building, student success, and knowledge creation. This paper will demonstrate how Lovejoy Library at Southern Illinois University Edwardsville has innovated library space to encourage practice-based play. We will provide insights into how other academic libraries can reimagine and redesign their spaces.We will discuss – through theories and our case study – the value of designing a library where we play every day. We understand student success is measured by retention and graduation rates; students are driven to graduate by outcomes (grades and degrees) and campus experiences (building community and a sense of belonging on campus). Academic libraries are uniquely situated to contribute to both motivators by creating spaces for formal and informal learning that are engaging, collaborative, and challenging. At Lovejoy Library, we innovated library space by theorizing play. Play is fun, engaging, spontaneous, disrupts power dynamics, and requires focus and rest; experiencing play is an act of mindfulness, essential to a student’s emotional health. Through renovations complete with a new MakerLab, furniture, equipment, resources, programs, and services, we created an environment to support student learning and well-being.
Play where you are
Authors: Williams Mita
Published: May 2022

This article argues for the position that libraries should develop, host, and encourage the community-creation of location-based games. While Pokémon Go has demonstrated that there is a sizable population ready to go outside to play, it also has left the impression that outdoor games require expensive mobile app-development. But very simple location-specific games can be designed by libraries that can help their community directly experience local sources of underappreciated spaces of natural beauty, help them discover overlooked historical places and their stories, and encourage them to stumble upon local art embedded in the landscape. Rather than only provide online escape rooms for those who may already feel confined by pandemic-related public health restrictions, libraries can create positive mental-health interventions that can also create the potential for a deeper connection between its readers and with where they live through site-specific games. This paper will provide examples of web-based and analog location-based games including a prototype developed by the author.
It's All Improv to Me
Authors: Cohn Sarah Brooks , Levitan Gina
Published: May 2022

Inspired by a workshop on incorporating improvisational techniques into classroom pedagogy, the in-class game Research Roulette was conceived as a way to incorporate improv and physical movement, with the specific goal of bringing a playful element into information literacy sessions. What shifts when the stated goal in a library workshop is to have fun and explore, instead of the prescriptive set of instructions of a more traditional bibliographic instruction? What happens when we move on from games and invite actual play? For students whose primary goal in a classroom or educational setting is to complete the work and do well, incorporating a playful element can be destabilizing. This article will explore the ways in which play, critical pedagogy, and information literacy intersect in the library classroom environment.
All work and all play: How McIntyre Library became our campus' playful experiential learning center
Authors: Sumbulla Helena , LaValle Liliana , Kishel Hans
Published: May 2022

While playing at work may sound incongruent, many of the staff at McIntyre Library at the University of Wisconsin – Eau Claire seek to provide the space and opportunities for students, staff, and faculty to infuse play into any aspect of their lives. To do this, we recognize a tension between being intentional with our outcomes, spaces, and programming, while providing flexibility for our users to improvise and discover what best serves their needs. After all, play is the clash of opportunity and creativity. Intrinsic to our work as librarians is a responsibility to our users; in encouraging play, both intentionally and unintentionally, our library invites users to assert themselves in a collaborative imagining of the tools, spaces, and resources we provide. By fostering an environment of playfulness, our staff strive to model and help users build skills for fun, lifelong experiential learning. In this article, we will trace McIntyre’s trajectory of play over the years to its current iteration. We have refined our approach to play to be included in staff and professional development seminars, to encourage a holistic view of wellness in how spaces in the library are structured, to creating a Makerspace and Digital Studio lab, and to be included in outreach events in the hopes of making the library more accessible to students.
Place, space and object oriented learning methods within the Library
Authors: Paton Jenni
Published: May 2022

A practical reflection of the impact of Escape Rooms style games both physical and digital on the way HE students experience the Library, examined through the lens of place oriented learning and digital learning theories with a particular focus on accessibility and the inclusion of historically excluded groups.We focus on two Escape Room style events, one physical, one digital developed by frontline library staff to support the induction of students in a University Library setting and reflect upon the aims, development and impact of the events.
Detection of Proximal Caries Lesions with Deep Learning Algorithm
Authors: Kim Hyuntae , Song Ji-Soo , Shin Teo Jeon , Hyun Hong-Keun , Kim Jung-Wook , Jang Ki-Taeg , Kim Young-Jae
Published: May 2022

This study aimed to evaluate the effectiveness of deep convolutional neural networks (CNNs) for diagnosis of interproximal caries in pediatric intraoral radiographs. A total of 500 intraoral radiographic images of first and second primary molars were used for the study. A CNN model (Resnet 50) was applied for the detection of proximal caries. The diagnostic accuracy, sensitivity, specificity, receiver operating characteristic (ROC) curve, and area under ROC curve (AUC) were calculated on the test dataset. The diagnostic accuracy was 0.84, sensitivity was 0.74, and specificity was 0.94. The trained CNN algorithm achieved AUC of 0.86. The diagnostic CNN model for pediatric intraoral radiographs showed good performance with high accuracy. Deep learning can assist dentists in diagnosis of proximal caries lesions in pediatric intraoral radiographs.
Recovery of Streptococcus Mutans Biofilm after Photodynamic Therapy with Erythrosine and LED Light Source
Authors: Shin Yongwook , Park Howon , Lee Juhyun , Lee Siyoung
Published: May 2022

The aim of this study was to evaluate the effects of erythrosine-mediated photodynamic therapy (PDT) on Streptococcus mutans biofilm recovery by counting its colony-forming units (CFUs) and via confocal laser scanning microscopy analysis at different time points following PDT. In PDT, photosensitizer was an erythrosine. S. mutans ATCC25175 biofilms were irradiated using an LED curing light. Chlorhexidine (CHX) was used as positive control. After each antimicrobial treatment, samples were cultured to allow biofilm recovery. Viability was measured by calculating the CFU counts after treatment and after every 3 hours for up to 24 hours. Immediately after treatment, the PDT and CHX groups showed equally significant decreases in S. mutans CFU counts compared to the negative control. After 12 hours of reculture, the PDT group showed no significant difference in the decrease in CFU count compared to the negative control, whereas the CHX group showed significantly lower CFU counts throughout the 24-hour period. Erythrosine-mediated PDT can effectively inhibit S. mutans biofilm formation. However, biofilm recovery occurred earlier in the CHX group after PDT. This study provides insights into the clinical effectiveness of PDT in preventing dental caries.
Fluoride Release of Several Types of Fluoride-Containing Restorative Materials According to Fluoride Concentration in Toothpaste
Authors: Lee Chungho , Lee Jewoo , Ra Jiyoung
Published: May 2022

This study was conducted to investigate the fluoride release of fluoride-containing restorative materials in fluoride recharging according to the concentration of fluoride toothpaste used in Korea.
Samples of glass ionomer cement, resin-modified glass ionomer cement, alkasite restorative material, and composite resin were prepared and fluoride release was measured on days 1, 3, 7, 14, 21, 28. Thereafter, fluoride-free, 500 ppm, and 1450 ppm fluoride toothpaste was applied to each restorative materials, and the fluoride release was measured on days 1, 3, 7.
Glass ionomer cement showed the highest cumulative fluoride release until the 7th day of measurement, and from the 14th day onwards, the resin-modified glass ionomer cement showed the highest cumulative fluoride release, but there was no significant difference.
When restorative material groups were recharged with 500 ppm of fluoride toothpaste, the fluoride release was significantly higher only for the alkasite restorative material compared to the fluoride-free toothpaste group (p < 0.017). When restorative material groups were recharged with 1450 ppm of fluoride toothpaste, the fluoride release was significantly higher in all restorative groups compared to the fluoride-free toothpaste group (p < 0.017).
Encorafenib and Binimetinib Combination Therapy in Metastatic Melanoma
Authors: Davis, PharmD, BCOP, CPP Jessica , Wayman, PharmD Megan
Published: May 2022

The treatment landscape for metastatic melanoma has changed dramatically over the past few years as new medications have been developed. Encorafenib, a B-Raf protein kinase inhibitor, and binimetinib, a MEK inhibitor, were approved by the U.S. Food and Drug Administration in 2018 for the treatment of patients with unresectable or metastatic melanoma which harbor a BRAF V600E or V600K mutation. These approvals were based on findings from the COLUMBUS trial, which demonstrated improvement in progression-free survival and overall survival with the combination of encorafenib plus binimetinib compared with vemurafenib alone. Encorafenib plus binimetinib is the third BRAF plus MEK inhibitor combination to be approved, and there are clinical and practical differences between the combination regimens that should be considered when selecting an appropriate treatment regimen for patients.
Praksisforskning
Authors: Uggerhøj Lars
Published: May 2022

The article describes the background and need for developing and initiating practice research in social work – including the possibility of connecting research, learning processes and knowledge production in practice. Furthermore, the possibilities of utilizing the knowledge, developed, but seldom made explicit, in practice, and the possibility of producing societal impact are described. Practice research is diverse, because it is negotiated by different stakeholders when launched. The article suggests a scientific position, a definition and a description of different approaches within practice research, which may support negotiations and discussions of practice research – among researchers and within collaborations between research and practice.
Notes on 1-Absorbing Prime Ideals
Authors: Bouba El Mehdi , Tamekkante Mohammed , Tekir Ünsal , Koç Suat
Published: May 2022

Let R be a commutative ring with a nonzero identity. A proper ideal I of R is said to be a 1-absorbing prime ideal if xyz ∈ I for some nonunits x, y, z ∈ R, then xy ∈ I or z ∈ I. It is well known that prime ideal ⇒ 1-absorbing prime ideal ⇒ primary ideal ⇒ semi-primary ideal, that is, the class of 1-absorbing prime ideals comes between the classes of prime ideals and primary ideals. Also, the above right arrows are not reversible. In this article, we characterize rings over which every 1-absorbing prime ideal is prime and every primary ideal is 1-absorbing prime. Also, by comparing 1-absorbing prime ideals and other some classical ideals such as 2-absorbing ideals and semi-primary ideals, we characterize Noetherian divided rings and von Neumann regular rings.
High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
Authors: Hostrup Morten , Lemminger Anders Krogh , Stocks Ben , Gonzalez-Franquesa Alba , Larsen Jeppe Kjærgaard , Quesada Julia Prats , Thomassen Martin , Weinert Brian Tate , Bangsbo Jens , Deshmukh Atul Shahaji
Published: May 2022

Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.
Water quality prediction in sea cucumber farming based on a GRU neural network optimized by an improved whale optimization algorithm
Authors: Yang Huanhai , Liu Shue
Published: May 2022

Sea cucumber farming is an important part of China’s aquaculture industry, and sea cucumbers have higher requirements for aquaculture water quality. This article proposes a sea cucumber aquaculture water quality prediction model that uses an improved whale optimization algorithm to optimize the gated recurrent unit neural network(IWOA-GRU), which provides a reference for the water quality control in the sea cucumber growth environment. This model first applies variational mode decomposition (VMD) and the wavelet threshold joint denoising method to remove mixed noise in water quality time series. Then, by optimizing the convergence factor, the convergence speed and global optimization ability of the whale optimization algorithm are strengthened. Finally, the improved whale optimization algorithm is used to construct a GRU prediction model based on optimal network weights and thresholds to predict sea cucumber farming water quality. The model was trained and tested using three water quality indices (dissolved oxygen, temperature and salinity) of sea cucumber culture waters in Shandong Peninsula, China, and compared with prediction models such as support vector regression (SVR), random forest (RF), convolutional neural network (CNN), recurrent neural network (RNN), and long short-term memory neural network (LSTM). Experimental results show that the prediction accuracy and generalization performance of this model are better than those of the other compared models.
The application of plant growth-promoting rhizobacteria in Solanum lycopersicum production in the agricultural system: a review
Authors: Adedayo Afeez Adesina , Babalola Olubukola Oluranti , Prigent-Combaret Claire , Cruz Cristina , Stefan Marius , Kutu Funso , Glick Bernard R.
Published: May 2022

Food safety is a significant challenge worldwide, from plantation to cultivation, especially for perishable products such as tomatoes. New eco-friendly strategies are needed, and beneficial microorganisms might be a sustainable solution. This study demonstrates bacteria activity in the tomato plant rhizosphere. Further, it investigates the rhizobacteria’s structure, function, and diversity in soil. Rhizobacteria that promote the growth and development of tomato plants are referred to as plant growth-promoting bacteria (PGPR). They form a series of associations with plants and other organisms in the soil through a mutualistic relationship where both parties benefit from living together. It implies the antagonistic activities of the rhizobacteria to deter pathogens from invading tomato plants through their roots. Some PGPR are regarded as biological control agents that hinder the development of spoilage organisms and can act as an alternative for agricultural chemicals that may be detrimental to the health of humans, animals, and some of the beneficial microbes in the rhizosphere soil. These bacteria also help tomato plants acquire essential nutrients like potassium (K), magnesium (Mg), phosphorus (P), and nitrogen (N). Some rhizobacteria may offer a solution to low tomato production and help tackle food insecurity and farming problems. In this review, an overview of soil-inhabiting rhizobacteria focused on improving the sustainable production of Solanum lycopersicum.
Epidemiology ofHelicobacter pyloriin Australia: a scoping review
Authors: Congedi Jillian , Williams Craig , Baldock Katherine L.
Published: May 2022

Background

Helicobacter pylori(H. pylori), a bacterium implicated in the development of peptic ulcer and gastric cancer, is estimated to infect around half the world’s population. Its prevalence in Australia is unclear. This scoping review aimed to evaluate all Australian literature providing estimates of the prevalence ofH. pylori.

Methods

Australian studies examiningH. pyloriprevalence from 1982 onwards were eligible for inclusion. Medline, Embase and Scopus databases, and grey literature sources, were searched. Two independent reviewers undertook a two-stage screening process. Data were extracted by two independent reviewers using a pre-specified template.

Results

Of 444 identified studies, 75 were included in the review.H. pyloriprevalence in Australian population-based studies (n = 8) ranged from 38.0% in 1991 to 15.1% in 2002; however, estimated prevalence across all non-clinical population studies in diverse sub-groups (n = 29) has varied dramatically. Decreased prevalence has been more marked in populations with gastrointestinal symptoms and conditions compared to non-clinical populations. Data onH. pyloriprevalence in vulnerable populations are lacking.

Conclusions

This is the first scoping review of Australian studies reportingH. pyloriprevalence. A wide range of study designs, population groups, geographic regions, and diagnostic methods was included, involving data collected over a 50-year period (1969 to 2018). The summary ofH. pyloriprevalence estimates over time in this review points to a decrease in prevalence in Australia, particularly among populations with gastrointestinal symptoms and illnesses; however, it is unknown whether there is inequity in prevalence trends across vulnerable sub-groups of the Australian population. Future research and interventions supporting the health and wellbeing of vulnerable populations is required to ensure equitable health gains are made for all.
Population genetics and demography of the coral-killing cyanobacteriosponge, Terpios hoshinota, in the Indo-West Pacific
Authors: Chow Savanna Wenhua , Keshavmurthy Shashank , Reimer James Davis , de Voogd Nicole , Huang Hui , Wang Jih-Terng , Tang Sen-Lin , Schupp Peter J. , Tan Chun Hong , Liew Hock-Chark , Soong Keryea , Subhan Beginer , Madduppa Hawis , Chen Chaolun Allen
Published: May 2022

The first occurrence of the cyanobacteriosponge Terpios hoshinota was reported from coral reefs in Guam in 1973, but was only formally described in 1993. Since then, the invasive behavior of this encrusting, coral-killing sponge has been observed in many coral reefs in the West Pacific. From 2015, its occurrence has expanded westward to the Indian Ocean. Although many studies have investigated the morphology, ecology, and symbiotic cyanobacteria of this sponge, little is known of its population genetics and demography. In this study, a mitochondrial cytochrome oxidase I (COI) fragment and nuclear ribosomal internal transcribed spacer 2 (ITS2) were sequenced to reveal the genetic variation of T. hoshinota collected from 11 marine ecoregions throughout the Indo-West Pacific. Both of the statistical parsimony networks based on the COI and nuclear ITS2 were dominated by a common haplotype. Pairwise FST and Isolation-by-distance by Mantel test of ITS2 showed moderate gene flow existed among most populations in the marine ecoregions of West Pacific, Coral Triangle, and Eastern Indian Ocean, but with a restricted gene flow between these regions and Maldives in the Central Indian Ocean. Demographic analyses of most T. hoshinota populations were consistent with the mutation-drift equilibrium, except for the Sulawesi Sea and Maldives, which showed bottlenecks following recent expansion. Our results suggest that while long-range dispersal might explain the capability of T. hoshinota to spread in the IWP, stable population demography might account for the long-term persistence of T. hoshinota outbreaks on local reefs.
Voluntariado, organizaciones o acción no convencional ¿qué mueve a los jóvenes chilenos?
Authors: Mardones Arévalo Roberto
Published: May 2022

Según datos de la novena encuesta de juventud, publicada en diciembre de 2019, la participación de los jóvenes en todo tipo de instancias está en bajos niveles. Este trabajo utiliza la base de datos de la encuesta (N=9700) y tiene por objetivo analizar la participación de los jóvenes en tres dimensiones disponibles en la misma: voluntariado, organizaciones y acciones no convencionales. Las variables explicativas serán: edad, sexo, nivel socioeconómico, nivel educativo, calidad de la educación ciudadana, interés por la política y conversación sobre política. Para llevar a cabo el análisis haremos uso de la regresión logística, para lo cual trabajaremos con el software SPSS 25. En general, todas las variables inciden significativamente en las tres dimensiones, salvo el nivel socioeconómico que no es significativo en una de ellas: participación en voluntariado. Asimismo, dentro del rango etario que cubre la encuesta, 15 – 29 años, es el grupo más joven, 15 – 19, el que está más involucrado.
Respuestas estatales a la pandemia de COVID-19 en Ecuador: mirando más allá del Ejecutivo
Authors: Zurita Tapia José , Medina Pérez Pablo
Published: May 2022

El presente artículo tiene como finalidad describir las respuestas del Estado ecuatoriano frente a la crisis sanitaria del COVID-19. Conscientes de que en América Latina contamos con países altamente dependientes del Ejecutivo, describimos el rol del Legislativo, Corte Constitucional, Consejo de Participación Ciudadana y Control Social, Defensoría del Pueblo, Contraloría General del Estado y Consejo Nacional Electoral, en el manejo de la crisis sanitaria. Pese a que cada organismo tiene atribuciones propias y procesos de toma de decisiones independientes, nos centramos en el Ecuador para observar el rol de organismos del gobierno central, más allá del poder Ejecutivo, durante la pandemia de COVID-19, tanto en relación con sus funciones específicas como en el marco de pesos y contrapesos del sistema institucional ecuatoriano.
El concepto de crimen organizado: ciertos elementos para una mayor concreción
Authors: Malamud Herrera Samuel
Published: May 2022

Asumiendo la escasa vocación comunicativa del término crimen organizado, para describir un ámbito delictual con precisión y extendiendo tal crítica a su expresión normativa más difundida: la definición de «grupo delictivo organizado» presente en la Convención de las Naciones Unidas contra la Delincuencia Organizada Transnacional, el presente artículo propone una serie de características y elementos que permitan entregar una mayor concreción a tal ámbito delictual.
El sistema comercial internacional: Reflexiones a partir del Congreso de Viena
Authors: Tijmes Ihl Jaime Andrés
Published: May 2022

Esta reflexión plantea un diálogo entre el Congreso de Viena y el escenario que enfrenta actualmente el sistema comercial internacional. El Congreso se nutrió de una visión común sobre la situación y los desafíos de esa época. Esos valores compartidos fueron uno de los factores que reforzaron los resultados positivos del Congreso. Por su parte, el sistema comercial actual está enfrentando una situación en la que los valores compartidos respecto del libre comercio parecen estarse debilitando, lo que plantea la pregunta por las consecuencias que eso tendrá.
EFECTOS DE LA INTERRUPCIÓN ESTABLECIDA EN EL ARTÍCULO 201 NÚMERO 3° DEL CÓDIGO TRIBUTARIO EN LA PRESCRIPCIÓN TRIBUTARIA
Authors: Fernández Aguayo Martin , Alarcón Cañuta Miguel
Published: May 2022

El presente artículo busca dar una solución defi nitiva, de la mano con la certe-za jurídica, a la problemática jurídico-social que se genera por la falta de regu-lación expresa de los efectos de la interrupción de la prescripción del artículo 201 número 3°del Código Tributario. Par a lo anterior, a partir del caso especí-fi co, se responde a la interrogante base de la problemática, esto es, si una vez producida tal interrupción, comienza o no a correr un nuevo plazo de prescrip-ción de la acción del Fisco para perseguir el pago de los impuestos, intereses, sanciones y demás recargos; examinando las normas legales que gobiernan la institución, y analizando la doctrina y jurisprudencia relacionada con el tema.