bluuebunny/crossref_metadata_2025 huggingface dataset:
Flexible composite film with artificial opal photonic crystals for efficient all-day passive radiative cooling
Authors: Nan Feng , Zhu Yu-Fu , Wei Huai-Xin , Lin Yi , Fan Baolu , Zhou Lei
Published: February 2022

All-day passive radiative cooling has recently attracted broader attention for its potential as a viable energy technology. Although tremendous progress has been achieved, the design and fabrication of low-cost high-efficiency radiators for all-day passive radiative cooling remains a challenge. Herein, we report a new type of flexible composite radiator film with built-in artificial opal-like structures for all-day passive radiative cooling. Using artificial opal structure concepts, the proposed polydimethylsiloxane (PDMS) radiator film with embedded polystyrene (PS) microsphere photonic crystals exhibits a sufficiently high solar reflectance of ∼92.7% when in a direct sunlight region, and a thermal emittance of ∼93.6% within the atmospheric window. Without the need for traditional reflectors like silver or aluminum foils, this composite film realizes subambient temperature reduction of ∼4.8 °C in direct sunlight and ∼8.5 °C during the night. This work provides a new fabrication approach for the low-cost production of structural polymer films for high performance and potential real word applications.
Optimization of gain region in mid-IR ( ≈ 5 μm) QCL
Authors: Kolek Andrzej , Hałdaś Grzegorz
Published: February 2022

Non-equilibrium Green’s function (NEGF) formalism is used to optimize the gain region of a quantum cascade laser (QCL) tailored to emit radiation at ∼5 µm wavelength, originally designed by Evans et al. [Appl. Phys. Lett., 88, 051105(2006)10.1063/1.2171476]. The optimization strategy uses electron-photon selfenergies to find characteristics of devices under the "operating conditions," i.e., interacting with the laser field. These conditions can be quite different from the one when the device is in no-lasing state and the unsaturated gain is being optimized. The saturation caused by the optical field can push the structure from strong to weak coupling conditions, what changes laser parameters in a non-linear manner. Moreover, the NEGF method does not require any phenomenological parameters (such as, e.g., the phase relaxation times), so the quantities dependent on these parameters are determined solely on physical grounds. The use of the above procedure for the structure under investigation shows that the increase of the quantum efficiency by 24% and the output power by 83% in comparison to the original design can be achieved when the widths of injection and extraction barriers are changed to their optimal values.
Arbitrary large-gradient wavefront shaping: from local phase modulation to nonlocal diffraction engineering
Authors: Dong Xipu , Cheng Jierong , Yuan Yiwu , Xing Zhenyu , Fan Fei , Wang Xianghui , Chang Shengjiang
Published: February 2022

The powerful wavefront manipulation capability of metasurfaces originates from their subwavelength or deep subwavelength elements with designable optical responses, especially phase responses. However, they usually suffer from performance degradation as the spatial phase gradient is large. To solve this issue, we propose an accurate and efficient nonlocal diffraction engineering mechanism to tailor an arbitrary large-gradient wavefront utilizing superwavelength-scale elements. The fast-varying phase profile is cut into segments according to

2
π

zones rather than subwavelength discretization. Each phase segment is accurately implemented by precisely tailoring the diffraction pattern of the element, where diffraction angles, efficiencies, and phases are controlled simultaneously. As proof of the concept, high numerical aperture cylindrical metalenses are designed using this method and experimentally validated at the terahertz band. The cylindrical metalens is further extended to a full-space metalens, which enables high-quality subwavelength imaging with resolved details of

0.65
λ

. The proposed mechanism offers an efficient way to capture the fast-varying wavefront using relatively coarse geometries with new physical insights.
Exploitation of geometric and propagation phases for spin-dependent rational-multiple complete phase modulation using dielectric metasurfaces
Authors: Khalid Ata Ur Rahman , Feng Fu , Ullah Naeem , Yuan Xiaocong , Somekh Michael Geoffrey
Published: February 2022

Metasurfaces have drawn considerable attention in manipulation of electromagnetic waves due to their exotic subwavelength footprints. Regardless of immense progress of polarization-dependent flat optics, the realization of on-device switchable complete phase multiplication is still missing from design multifunctional devices. Here, by combining geometric and propagation phases, a generalized design principle is proposed that can achieve switchable integer or fractional multiple complete phase modulation in transmitted circularly cross-polarized light by switching the handedness of incident polarization. As a proof of concept, two types of spin-dependent bifunctional wavefront manipulating devices, including switchable beam splitter/beam deflector and spin-to-orbital angular momentum converter designs are numerically realized. It is believed that the proposed single-cell spin-switchable rational-multiple complete-phase-modulation design principle based on combined propagation and geometric phases has great potential to underpin the development of meta-optics-based multifunctional operations in the field of integrated optics, imaging, and optical communication.
Topological multipolar corner state in a supercell metasurface and its interplay with two-dimensional materials
Authors: Zhang Zhaojian , Yang Junbo , Du Te , Jiang Xinpeng
Published: February 2022

Second-order topological insulators (SOTIs) have recently attracted much attention due to their capability to support lower-dimensional topological states, namely, the corner states. Here, we demonstrate that properly designed supercell metasurfaces can support photonic corner states, meanwhile further serving as an ideal platform for the implementations of topological polaritons and dynamically reconfigurable corner states by assembling two-dimensional materials. Such metasurfaces consist of an array of finite-sized SOTIs mimicking the two-dimensional Su–Schrieffer–Heeger model. We reveal that the topological transition happens in unit cells without the bandgap, and nondegenerate multipolar corner states emerge in the supercell metasurface due to the inter- and intrasupercell coupling effects. Especially since these corner states are above the light line of the metasurface, we realize the collective stimulation of the two dipolar corner states and their superposition state via far-field excitation. By stacking monolayer hexagonal boron nitride film onto the metasurface, we further achieve the topological phonon polaritons through the strong coupling between the corner state and the phonon, which is confirmed by the Rabi splitting as well as anticrossing behavior emerging in the transmission spectra. Furthermore, we reveal the robustness of the corner state and strong coupling by introducing defects into the metasurface. Finally, tunable corner state and strong coupling with on-demand control are realized by assembling monolayer graphene onto the metasurface. Our theoretical study proposes a unique hybrid-material platform for topological polaritonics and reconfigurable topological photonics, which can promote large-area topological applications in practice.
Optical topological lattices of Bloch-type skyrmion and meron topologies
Authors: Zhang Qiang , Xie Zhenwei , Shi Peng , Yang Hui , He Hairong , Du Luping , Yuan Xiaocong
Published: February 2022

Optical skyrmions, quasiparticles that are characterized by the topologically nontrivial vectorial textures of optical parameters such as the electromagnetic field, Stokes parameters, and spin angular momentum, have aroused great attention recently. New dimensions for optical information processing, transfer, and storage have become possible, and developing multiple schemes for manipulating the topological states of skyrmions, thus, is urgent. Here we propose an approach toward achieving dynamic modulation of skyrmions via changing the field symmetry and adding chirality. We demonstrate that field symmetry governs the skyrmionic transformation between skyrmions and merons, whereas material chirality modulates the twist degree of fields and spins and takes control of the Néel-type–Bloch-type skyrmionic transition. Remarkably, the enantioselective twist of skyrmions and merons results from the longitudinal spin arising from the chirality-induced splitting of the hyperboloid in the momentum space. Our investigation, therefore, acts to enrich the portfolio of optical quasiparticles. The chiral route to topological state transitions will deepen our understanding of light–matter interaction and pave the way for chiral sensing, optical tweezers, and topological phase transitions in quantum matter.
Cervical Cancer Screening Cascade for women living with HIV: A cohort study from Zimbabwe
Authors: Taghavi Katayoun , Mandiriri Ardele , Shamu Tinei , Rohner Eliane , Bütikofer Lukas , Asangbeh Serra , Magure Tsitsi , Chimbetete Cleophas , Egger Matthias , Pascoe Margaret , Bohlius Julia
Published: February 2022

Countries with high HIV prevalence, predominantly in sub-Sahahran Africa, have the highest cervical cancer rates globally. HIV care cascades successfully facilitated the scale-up of antiretroviral therapy. A cascade approach could similarly succeed to scale-up cervical cancer screening, supporting WHO’s goal to eliminate cervical cancer. We defined a Cervical Cancer Screening Cascade for women living with HIV (WLHIV), evaluating the continuum of cervical cancer screening integrated into an HIV clinic in Zimbabwe. We included WLHIV aged ≥18 years enrolled at Newlands Clinic in Harare from June 2012–2017 and followed them until June 2018. We used a cascade approach to evaluate the full continuum of secondary prevention from screening to treatment of pre-cancer and follow-up. We report percentages, median time to reach cascade stages, and cumulative incidence at two years with 95% confidence intervals (CI). We used univariable Cox proportional hazard regressions to calculate cause-specific hazard ratios with 95% CIs for factors associated with completing the cascade stages. We included 1624 WLHIV in the study. The cumulative incidence of cervical screening was 85.4% (95% CI 83.5–87.1) at two years. Among the 396 WLHIV who received screen-positive tests in the study, the cumulative incidence of treatment after a positive screening test was 79.5% (95% CI 75.1–83.2) at two years. The cumulative incidence of testing negative at re-screening after treatment was 36.1% (95% CI 31.2–40.7) at two years. Using a cascade approach to evaluate the full continuum of cervical cancer screening, we found less-than 80% of WLHIV received treatment after screen-positive tests and less-than 40% were screen-negative at follow-up. Interventions to improve linkage to treatment for screen-positive WLHIV and studies to understand the clinical significance of screen-positive tests at follow-up among WLHIV are needed. These gaps in the continuum of care must be addressed in order to prevent cervical cancer.
Echinococcus multilocularis specific antibody, systemic cytokine, and chemokine levels, as well as antigen-specific cellular responses in patients with progressive, stable, and cured alveolar echinococcosis: A 10-year follow-up
Authors: Grüner Beate , Peters Lynn , Hillenbrand Andreas , Voßberg Patrick , Schweiker Jonas , Rollmann Elisabeth G. , Rodriguez Laura H. , Blumhardt Jasmin , Burkert Sanne , Kern Peter , Köhler Carsten , Soboslay Peter T.
Published: February 2022

Background

The infestation withEchinococcus multilocularislarvae may persist in humans for up to decades without evident clinical symptoms. Longitudinal investigations are needed to understand the dynamic immunological processes in alveolar echinococcosis (AE) patients associated with an active and progressive, a stable or a regressive course of disease.

Methodology/Principal findings

This study evaluated theE.multilocularisspecific antibody responses, systemic cytokine, and chemokine serum levels over a 10-year follow-up period, as well as cellular responsiveness in AE patients. Our results demonstrate a rapid decrease in antibodies againstE.multilocularisspecific antigen Em2+. Especially in cured patients, these antibodies remained negative, making them a significant predictor for cured AE.E.multilocularisspecific IgG4, and indirect hemagglutination IHA decreased later in time, after around 5 years. While total IgE did not show significant dynamics over the course of disease,E.multilocularisspecific IgE decreased after one to two years, and increasing levels were a significant predictor of progressive disease. There was no significant change in systemic IL-8, IL-9, CCL18 or CCL20 serum levels over time. Univariate analysis across groups indicated lower IL-8 levels in cured patients; however, this result could not be confirmed by multivariate analysis. Levels of CCL17 decreased during treatment, especially in cured patients, and thus might serve as a predictive or risk factor for progressive disease. Levels of IL-10 and CCL13 decreased during disease, especially after five and ten years of intervention. TheE.multilocularisantigen (EmAg) inducible cellular productions of MCP1(CCL13), TARC(CCL17) and PARC(CCL18) were lowest in patients with cured AE and infection-free controls, while the EmAg inducible cellular production of IFN-γ increased after cure. Significant positive cytokine and chemokine correlations were observed in AE patients for IL-9, IL-10, CCL13(MCP-4), CCL17(TARC) and CCL20(LARC)(for all p<0.001).E.multilocularisspecific IgG4 response correlated positively with TARC (p<0.001). Both markers enhanced over time in progressive disease and decreased after cure. The levels of IL-8, IL-10, MCP4 and LARC enhanced with AE regression.

Conclusions/Significance

Repeated biomarker surveys are advisable to evaluate progression or regression of disease during longitudinal follow-up and such analyses can support imaging techniques and improve staging of AE patients.
Hierarchical development of dominance through the winner-loser effect and socio-spatial structure
Authors: van Haeringen Erik , Hemelrijk Charlotte
Published: February 2022

In many groups of animals the dominance hierarchy is linear. What mechanisms underlie this linearity of the dominance hierarchy is under debate. Linearity is often attributed to cognitively sophisticated processes, such as transitive inference and eavesdropping. An alternative explanation is that it develops via the winner-loser effect. This effect implies that after a fight has been decided the winner is more likely to win again, and the loser is more likely to lose again. Although it has been shown that dominance hierarchies may develop via the winner-loser effect, the degree of linearity of such hierarchies is unknown. The aim of the present study is to investigate whether a similar degree of linearity, like in real animals, may emerge as a consequence of the winner-loser effect and the socio-spatial structure of group members. For this purpose, we use the model DomWorld, in which agents group and compete and the outcome of conflicts is self-reinforcing. Here dominance hierarchies are shown to emerge. We analyse the dominance hierarchy, behavioural dynamics and network triad motifs in the model using analytical methods from a previous study on dominance in real hens. We show that when one parameter, representing the intensity of aggression, was set high in the model DomWorld, it reproduced many patterns of hierarchical development typical of groups of hens, such as its high linearity. When omitting from the model the winner-loser effect or spatial location of individuals, this resemblance decreased markedly. We conclude that the combination of the spatial structure and the winner-loser effect provide a plausible alternative for hierarchical linearity to processes that are cognitively more sophisticated. Further research should determine whether the winner-loser effect and spatial structure of group members also explains the characteristics of hierarchical development in other species with a different dominance style than hens.
Incidence of non-Hodgkin’s lymphoma among adults in Sardinia, Italy
Authors: Broccia Giorgio , Carter Jonathan , Ozsin-Ozler Cansu , Meloni Federico , De Matteis Sara , Cocco Pierluigi
Published: February 2022

The causes of the peculiar time trend in the incidence of non-Hodgkin’s lymphoma (NHL) in most parts of the world and of its geographic distribution are still unknown. We used the data base of 1974–2003 incident cases of hematological malignancies to explore the time trend of NHL incidence in the region of Sardinia, Italy, and we used Bayesian methods to plot the probability of NHL incidence by residential unit on the regional map. In 1974–2003, 4109 NHL cases were diagnosed among resident adults in Sardinia, with an incidence rate of 13.38 x 10−5(95% CI 12.97–13.80). NHL incidence showed an upward trend along the study period with an average annual percent change (APC) of 4.94 (95% CI -5.39–16.4), which did not vary by gender or by age-group. Cancer registry data, covering part of the region starting from 1993, suggest that the increasing trend did not persist in the subsequent years. Areas with the highest probability of an excess incidence tended to cluster in the north-eastern part of the region and in two major urban centers, with the low incidence areas located in the south, confirming previous observations. Prevalence of viral infections, environmental and occupational exposures, or socio-economic deprivation would not explain the peculiar geographic distribution we observed. These findings provide convincing arguments for extending the coverage of routine cancer registration over the whole Sardinian population, while prompting further research on the genetic and environmental determinants of NHL in the risk areas.
RAVAL trial: Protocol of an international, multi-centered, blinded, randomized controlled trial comparing robotic-assisted versus video-assisted lobectomy for early-stage lung cancer
Authors: Patel Yogita S. , Hanna Waël C. , Fahim Christine , Shargall Yaron , Waddell Thomas K. , Yasufuku Kazuhiro , Machuca Tiago N. , Pipkin Mauricio , Baste Jean-Marc , Xie Feng , Shiwcharan Andrea , Foster Gary , Thabane Lehana
Published: February 2022

Background

Retrospective data demonstrates that robotic-assisted thoracoscopic surgery provides many benefits, such as decreased postoperative pain, lower mortality, shorter length of stay, shorter chest tube duration, and reductions in the incidence of common postoperative pulmonary complications, when compared to video-assisted thoracoscopic surgery. Despite the potential benefits of robotic surgery, there are two major barriers against its widespread adoption in thoracic surgery: lack of high-quality prospective data, and the perceived higher cost of it. Therefore, in the face of these barriers, a prospective randomized controlled trial comparing robotic- to video-assisted thoracoscopic surgery is needed. The RAVAL trial is a two-phase, international, multi-centered, blinded, parallel, randomized controlled trial that is comparing robotic- to video-assisted lobectomy for early-stage non-small cell lung cancer that has been enrolling patients since 2016.

Methods

The RAVAL trial will be conducted in two phases: Phase A will enroll 186 early-stage non-small cell lung cancer patients who are candidates for minimally invasive pulmonary lobectomy; while Phase B will continue to recruit until 592 patients are enrolled. After consent, participants will be randomized in a 1:1 ratio to either robotic- or video-assisted lobectomy, and blinded to the type of surgery they are allocated to. Health-related quality of life questionnaires will be administered at baseline, postoperative day 1, weeks 3, 7, 12, months 6, 12, 18, 24, and years 3, 4, 5. The primary objective of the RAVAL trial is to determine the difference in patient-reported health-related quality of life outcomes between the robotic- and video-assisted lobectomy groups at 12 weeks. Secondary objectives include determining the differences in cost-effectiveness, and in the 5-year survival data between the two arms. The results of the primary objective will be reported once Phase A has completed accrual and the 12-month follow-ups are completed. The results of the secondary objectives will be reported once Phase B has completed accrual and the 5-year follow-ups are completed.

Discussion

If successfully completed, the RAVAL Trial will have studied patient-reported outcomes, cost-effectiveness, and survival of robotic- versus video-assisted lobectomy in a prospective, randomized, blinded fashion in an international setting.

Trial registration

ClinicalTrials.gov, NCT02617186. Registered 22-September-2015. https://clinicaltrials.gov/ct2/show/NCT02617186
How the Black Swan damages the harvest: Extreme weather events and the fragility of agriculture in development countries
Authors: Marmai Nadine , Franco Villoria Maria , Guerzoni Marco
Published: February 2022

Climate change constitutes a rising challenge to the agricultural base of developing countries. Most of the literature has focused on the impact of changes in the means of weather variables on mean changes in production and has found very little impact of weather upon agricultural production. Instead, we focus on the relationship between extreme events in weather and extreme losses in crop production. Indeed, extreme events are of the greatest interest for scholars and policy makers only when they carry extraordinary negative effects. We build on this idea and for the first time, we adopt a conditional dependence model for multivariate extreme values to understand the impact of extreme weather on agricultural production. Specifically, we look at the probability that an extreme event drastically reduces the harvest of any of the major crops. This analysis, which is run on data for six different crops and four different weather variables in a vast array of countries in Africa, Asia and Latin America, shows that extremes in weather and yield losses of major staples are associated events. We find a high heterogeneity across both countries and crops and we are able to predict per country and per crop the risk of a yield reduction above 90% when extreme events occur. As policy implication, we can thus assess which major crop in each country is less resilient to climate shocks.
A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB
Authors: Korunes Katharine L. , Liu Jie , Huang Ruili , Xia Menghang , Houck Keith A. , Corton J. Christopher
Published: February 2022

The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expression biomarker predictive of NF-κB modulation and used the biomarker to screen a large compendia of gene expression data. The biomarker consists of 108 genes responsive to tumor necrosis factor α in the absence but not the presence of IκB, an inhibitor of NF-κB. Using a set of 450 profiles from cells treated with immunomodulatory factors with known NF-κB activity, the balanced accuracy for prediction of NF-κB activation was > 90%. The biomarker was used to screen a microarray compendium consisting of 12,061 microarray comparisons from human cells exposed to 2,672 individual chemicals to identify chemicals that could cause toxic effects through NF-κB. There were 215 and 49 chemicals that were identified as putative or known NF-κB activators or suppressors, respectively. NF-κB activators were also identified using two high-throughput screening assays; 165 out of the ~3,800 chemicals (ToxCast assay) and 55 out of ~7,500 unique compounds (Tox21 assay) were identified as potential activators. A set of 32 chemicals not previously associated with NF-κB activation and which partially overlapped between the different screens were selected for validation in wild-type and NFKB1-null HeLa cells. Using RT-qPCR and targeted RNA-Seq, 31 of the 32 chemicals were confirmed to be NF-κB activators. These results comprehensively identify a set of chemicals that could cause toxic effects through NF-κB.
Drivers of cadmium accumulation in Theobroma cacao L. beans: A quantitative synthesis of soil-plant relationships across the Cacao Belt
Authors: Wade Jordon , Ac-Pangan Marlon , Favoretto Vitor R. , Taylor Alexander J. , Engeseth Nicki , Margenot Andrew J.
Published: February 2022

Elevated cadmium (Cd) concentrations in cacao and cocoa-based products (e.g., chocolate) present a potentially serious human health risk. While recent regulatory changes have established a threshold of 0.8 mg kg-1for Cd content of cocoa-based products, the biophysical factors (e.g., climatic or edaphic conditions) that determine the amount of soil-derived Cd in the cacao bean are poorly understood and have yet to be quantitatively assessed across diverse production contexts. To determine the primary drivers of cacao bean Cd, we used the scientific literature to systematically compile a database of climatic, edaphic, and plant data from across the Cacao Belt, which is approximately 20 degrees latitude on either side of the equator. From this compiled dataset, we then used boosted regression trees to quantitatively synthesize and evaluate these drivers of cacao bean Cd. Total soil Cd concentration, soil pH, and leaf Cd were the best predictors of bean Cd content. Notably, we found that both available soil Cd and soil organic carbon (SOC) content had negligible effects on bean Cd. However, soil pH and SOC decreased the degree of bioconcentration of total soil Cd in the bean Cd concentration. Thus, given the difficulty in remediating soil Cd enriched soils, our results suggest that Cd mitigation strategies targeting plant physiology-based approaches (e.g., breeding, rootstocks) have a higher probability of success than soil-based strategies (e.g., remediation).
An exploratory survey on community pharmacists’ service provision for pregnant and lactating women in Sharjah, United Arab Emirates
Authors: Akkad Zahraa Abdullatif , Alomar Muaed , Palaian Subish
Published: February 2022

Over-the-counter (OTC) medications are generally deemed safe to be used during pregnancy and lactation. However, some products can be harmful to the mother, fetus or breast-fed child, which presents a challenge to health professionals and consumers. This study was aimed at assessing the practice of OTC medication dispensing and counseling services provided to pregnant and lactating by community pharmacists (CPs). A cross-sectional descriptive questionnaire-based survey was answered during February—November 2020, by licensed CPs practicing in Sharjah, United Arab Emirates. The determination of the significant factors associated with the CPs’ views and OTC medication dispensing during pregnancy and breastfeeding was carried out using logistic regression. Among 256 respondents, dispensing medicines and referral to a physician were the predominant services provided to pregnant and lactating women. Respondents dispensed medications mostly to treat headache (74.2%), fever (62.5%) in pregnant women, and headache (81.3%) and fever (65.2%) in lactating mothers. Referral to a physician was common in pregnant women in the following cases: varicose veins (72.7%), swelling of the feet and legs (71.9%), and vaginal itching (53.9%). In breastfeeding women, the referrals were commonly for varicose veins (79.7%), swelling of the feet and legs (73.0%) and mastitis (70.3%). Most participants came to an agreement that CPs are capable of counselling and providing pregnant and lactating women the best OTC treatment. Around 35% of the respondents stated that OTC medicines are not safe to be used during pregnancy. One in five respondents stated that OTC medicines are not safe for breastfeeding women. CPs were confident to counsel and provide advice to pregnant and breastfeeding women to address medication and health problems. Proper utilization of CPs can contribute largely to the healthcare system in managing common minor ailments in pregnant and lactating women, reducing the need to visit the physician and enhancing patient safety.
Translating mentoring interventions research into practice: Evaluation of an evidence-based workshop for research mentors on developing trainees’ scientific communication skills
Authors: Dahlstrom Erin K. , Bell Christine , Chang Shine , Lee Hwa Young , Anderson Cheryl B. , Pham Annie , Pribbenow Christine Maidl , Cameron Carrie A.
Published: February 2022

A key part of keeping doctoral and postdoctoral trainees in STEM research careers is mentoring. Our previous research indicates that mentoring trainees in scientific communication (SC) skill development increases research career intention through two social-cognitive constructs, self-efficacy in and outcome expectations for acquiring SC skills, as well as science identity. While many mentor training interventions exist, no programs focus on developing SC skills specifically. The “Scientific Communication Advances Research Excellence” (SCOARE) program trains mentors to address trainee scientific communication (SC) skill development as an innovative approach to increase trainee research career persistence. The SCOARE training is a half-day workshop for faculty mentors of research trainees at five sites nationally. Informed by previous research, workshop content focuses on practical, effective mentoring strategies to develop trainee speaking and writing skills. Anonymous evaluation data collected after each workshop indicates participant satisfaction and reported positive increases in skills and knowledge in applying new and various techniques when mentoring trainees (skills) and how linguistic bias influences our perception of others (knowledge). This article outlines the research-based development of the SCOARE program, the first two years’ of workshop evaluations showing positive increases in skills and knowledge, and lessons learned to increase participant satisfaction with the program.
Tracking breastfeeding and weaning practices in ancient populations by combining carbon, nitrogen and oxygen stable isotopes from multiple non-adult tissues
Authors: Chinique de Armas Yadira , Mavridou Anna-Maria , Garcell Domínguez Jorge , Hanson Kaitlyn , Laffoon Jason
Published: February 2022

This paper explores the potential of combining different isotope systems from different tissues to improve resolution when reconstructing breastfeeding and weaning practices (BWP) in archaeology. Additionally, we tested whether changes in diet can be detected in deciduous teeth. Rib collagen samples from 22 infants/children from the archaeological site of Bacuranao I (Mayabeque, Cuba) were processed for nitrogen (δ15N) and carbon (δ13Cco) stable isotopes and assessed using a Bayesian model (WARN). In addition, enamel of 48 teeth from 30 infants/children were analyzed for oxygen (δ18Oen) and carbon (δ13Cen) stable isotopes. Data revealed that the timing of weaning cannot be characterized precisely by analyzing either δ18O or δ15N. While a depletion in both δ15N and δ13Ccois only evident after one year, the WARN model suggested that the weaning process started at around 3 months and ended around 1.7 years. Most teeth were enriched in δ18Oencompared to deciduous incisors, suggesting a breastfeeding signal. However, a high variability in δ18O was found between similar teeth from the same individuals. Higher enrichment in δ18Oen, and variability, was observed in tissues formed during the first six months of life. A δ13C enrichment of 1.0‰ was observed among deciduous teeth and ribs. While most individuals enriched in δ15N showed enrichment in δ13C, the δ18O values were more variable. Our data suggests that stable isotopes of deciduous teeth, especially δ13Cen, can be used to detect changes in diet during the weaning process. It is also possible that the δ18O enrichment observed in M1 is influenced by the effects of cooking techniques on weaning foods. The combination of multiple isotope systems and tissues overcome some of the limitations posed by single tissue approaches.
Beyond the ceremony: Mega-event, air quality and political career
Authors: Fang Li , He Pan , Tian Chuanhao , Yao Yao , Chen Hongjie
Published: February 2022

This paper examines whether mega-events-initiated planning regulations improved air quality in Chinese cities and explores the driving forces of the enforcement of such regulations. Using the 2008 Beijing Olympics as an example, we find that mega-events serve as an opportunity for cities to combat air pollution. The 2008 Olympics prompted a handful of Chinese cities to cut pollution and sustain a blue sky: Cities with air quality regulated for the Olympics cut their Air Pollution Index by about 16 points during the Games, compared to non-regulated cities, and 60% of that effect remained four years after the event. These achievements are obtained through effective mobilization of city leaders by associating air quality with their political careers. This study reveals that 1) a mega-event may improve urban environmental quality beyond the host cities and the event period, and 2) successful implementation of environmental regulations hinges on incentivizing local leaders.
Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences
Authors: Berntsen Jørgen , Rimestad Jens , Lassen Jacob Theilgaard , Tran Dang , Kragh Mikkel Fly
Published: February 2022

Assessing and selecting the most viable embryos for transfer is an essential part of in vitro fertilization (IVF). In recent years, several approaches have been made to improve and automate the procedure using artificial intelligence (AI) and deep learning. Based on images of embryos with known implantation data (KID), AI models have been trained to automatically score embryos related to their chance of achieving a successful implantation. However, as of now, only limited research has been conducted to evaluate how embryo selection models generalize to new clinics and how they perform in subgroup analyses across various conditions. In this paper, we investigate how a deep learning-based embryo selection model using only time-lapse image sequences performs across different patient ages and clinical conditions, and how it correlates with traditional morphokinetic parameters. The model was trained and evaluated based on a large dataset from 18 IVF centers consisting of 115,832 embryos, of which 14,644 embryos were transferred KID embryos. In an independent test set, the AI model sorted KID embryos with an area under the curve (AUC) of a receiver operating characteristic curve of 0.67 and all embryos with an AUC of 0.95. A clinic hold-out test showed that the model generalized to new clinics with an AUC range of 0.60–0.75 for KID embryos. Across different subgroups of age, insemination method, incubation time, and transfer protocol, the AUC ranged between 0.63 and 0.69. Furthermore, model predictions correlated positively with blastocyst grading and negatively with direct cleavages. The fully automated iDAScore v1.0 model was shown to perform at least as good as a state-of-the-art manual embryo selection model. Moreover, full automatization of embryo scoring implies fewer manual evaluations and eliminates biases due to inter- and intraobserver variation.
Untangling the tingle: Investigating the association between the Autonomous Sensory Meridian Response (ASMR), neuroticism, and trait & state anxiety
Authors: Eid Charlotte M. , Hamilton Colin , Greer Joanna M. H.
Published: February 2022

The Autonomous Sensory Meridian Response (ASMR) is an intensely pleasant tingling sensation originating in the scalp and neck and is elicited by a range of online video-induced triggers. Many individuals now regularly watch ASMR videos to relax, and alleviate symptoms of stress and insomnia, all which are indicative of elevated levels of anxiety. Emerging literature suggests that ASMR-capable individuals are characterised by high trait neuroticism, which is associated with a tendency to experience negative emotional states such as anxiety. To date however no literature has empirically linked these personality constructs and watching ASMR videos on the effect of reducing anxiety. In the current study, 36 ASMR-experiencers and 28 non-experiencers watched an ASMR video, and completed assessments of neuroticism, trait anxiety, and pre- / post-video state anxiety. MANCOVA with Group as the independent measures factor showed that ASMR-experiencers had significantly greater scores for neuroticism, trait anxiety, and video engagement than non-experiencers. Pre-video state anxiety was also significantly greater in the ASMR-experiencers and was significantly attenuated on exposure to the ASMR video, whereas non-experiencers reported no difference in state anxiety pre- and post-video. Thus, watching ASMR alleviated state anxiety but only in those who experienced ASMR. Subsequent mediation analyses identified the importance of pre-existing group differences in neuroticism, trait and (pre-video) state anxiety in accounting for the group difference in the reduction of state anxiety. The mediation analysis further lends support for watching ASMR videos as an intervention for the reduction of acute state anxiety. Future areas for research are discussed.
Detection of SARS-CoV-2 infection prevalence in 860 cancer patients with a combined screening procedure including triage, molecular nasopharyngeal swabs and rapid serological test. A report from the first epidemic wave
Authors: Candoni Anna , Petruzzellis Giuseppe , Sperotto Alessandra , Andreotti Victoria , Giavarra Marco , Corvaja Carla , Minisini Alessandro , Comuzzi Chiara , Tascini Carlo , Fanin Renato , Fasola Gianpiero
Published: February 2022

Introduction

Even if now we have available the weapon of vaccination against SARS-CoV-2, the patients with cancer remains a very frail population in which frequently the immunologic response to vaccination may be impaired. In this setting, the SARS-CoV-2 infection screening retains a great value. However, there are still limited data on the feasibility and efficacy of combined screening procedures to assess the prevalence of SARS-CoV-2 infection (including asymptomatic cases) in cancer outpatients undergoing antineoplastic therapy.

Patients and results

From May 1, 2020, to June 15, 2020, during the first wave of SARS-CoV-2 pandemic, 860 consecutive patients, undergoing active anticancer therapy, were evaluated and tested for SARS-CoV-2 with a combined screening procedure, including a self-report questionnaire, a molecular nasopharyngeal swab (NPS) and a rapid serological immunoassay (for anti-SARS-CoV-2 IgG/IgM antibodies). The primary endpoint of the study was to estimate the prevalence of SARS-CoV-2 infection (including asymptomatic cases) in consecutive and unselected cancer outpatients by a combined screening modality. A total of 2955 SARS-CoV-2 NPS and 860 serological tests, in 475 patients with hematologic cancers and in 386 with solid tumors, were performed. A total of 112 (13%) patients self-reported symptoms potentially COVID-19 related. In 1/860 cases (< 1%) SARS-CoV-2 NPS was positive and in 14 cases (1.62%) the specific serological test was positive (overall prevalence of SARS-CoV-2 infection 1.62%). Of the 112 cases who declared symptoms potentially COVID-19-related, only 2.7% (3/112) were found SARS-CoV-2 positive.

Conclusions

This is the largest study reporting the feasibility of a combined screening procedure (including triage, NPS and serologic test) to evaluate the prevalence of SARS-CoV-2 infection in cancer patients receiving active therapy, during the first epidemic wave and under the restrictive lockdown measures, in one of the active areas of the SARS-CoV-2 circulation. Lacking specific recommendations for the detection of asymptomatic SARS-CoV-2 cases, a combined diagnostic screening might be more effective to detect the exact prevalence of SARS-CoV-2 in neoplastic patient population. The prevalence can obviously change according to the territorial context, the entity of the restrictive measures adopted and the phase of the epidemic curve. However, its exact and real-time knowledge could be important to balance risks/benefits of oncologic treatments, avoiding (if the prevalence is low) the reduction of dose intensity or the selection of less intensive (but also less effective) anti-cancer therapies.
The dinosaur tracks of Tyrants Aisle: An Upper Cretaceous ichnofauna from Unit 4 of the Wapiti Formation (upper Campanian), Alberta, Canada
Authors: Enriquez Nathan J. , Campione Nicolás E. , White Matt A. , Fanti Federico , Sissons Robin L. , Sullivan Corwin , Vavrek Matthew J. , Bell Phil R.
Published: February 2022

The Wapiti Formation of northwest Alberta and northeast British Columbia, Canada, preserves an Upper Cretaceous terrestrial vertebrate fauna that is latitudinally situated between those documented further north in Alaska and those from southern Alberta and the contiguous U.S.A. Therefore, the Wapiti Formation is important for identifying broad patterns in vertebrate ecology, diversity, and distribution across Laramidia during the latest Cretaceous. Tracksites are especially useful as they provide a range of palaeoecological, palaeoenvironmental, and behavioural data that are complementary to the skeletal record. Here, we describe the Tyrants Aisle locality, the largestin-situtracksite known from the Wapiti Formation. The site occurs in the lower part of Unit 4 of the formation (~72.5 Ma, upper Campanian), exposed along the southern bank of the Redwillow River. More than 100 tracks are documented across at least three distinct track-bearing layers, which were deposited on an alluvial floodplain. Hadrosaurid tracks are most abundant, and are referable toHadrosauropodusbased on track width exceeding track length, broad digits, and rounded or bilobed heel margins. We suggest the hadrosaurid trackmaker wasEdmontosaurus regalisbased on stratigraphic context. Tyrannosaurids, probable troodontids, possible ornithomimids, and possible azhdarchid pterosaurs represent minor but notable elements of the ichnofauna, as the latter is unknown from skeletal remains within the Wapiti Formation, and all others are poorly represented. Possible social behaviour is inferred for some of the hadrosaurid and small theropod-like trackmakers based on trackway alignment, suitable spacing and consistent preservation. On a broad taxonomic level (i.e., family or above), ichnofaunal compositions indicate that hadrosaurids were palaeoecologically dominant across Laramidia during the late Campanian within both high-and low-latitude deposits, although the role of depositional environment requires further testing.
Entrepreneurial tendency across the adult lifespan
Authors: Zelekha Yaron , Kavé Gitit
Published: February 2022

This study examines whether age associates with entrepreneurship tendencies across the lifespan, after taking into account aspects of personality that affect entrepreneurship. Participants (N = 963) aged 18–81, including 200 actual entrepreneurs, completed questionnaires about entrepreneurship tendency, personality traits, and attachment orientations. Results show that age is associated with a reduced tendency to engage in entrepreneurial activity. However, this decline is quite limited, it weakens with age, and is absent after age 50. In addition, the negative association of age with entrepreneurial tendency is smaller in participants with above-median entrepreneurship tendency scores relative to those with below-median scores, and it disappears in actual entrepreneurs. Furthermore, most of the traits that have been previously associated with entrepreneurial tendencies, especially Openness to Experience and Extraversion, remain unchanged with age, accounting for the stability of entrepreneurial tendency over time. The results have implications for policy makers who wish to encourage older adults to engage in entrepreneurial activity.
U.S. postdoctoral careers in life sciences, physical sciences and engineering: Government, industry, and academia
Authors: Denton Maya , Borrego Maura , Knight David B.
Published: February 2022

Discussions about science and engineering postdoctoral researchers focus almost exclusively on academic postdocs and their chances of eventually securing tenure-track faculty positions. Further, biological sciences dominate policy research and published advice for new PhDs regarding postdoctoral employment. Our analysis uses the Survey of Earned Doctorates and Survey of Doctorate Recipients to understand employment implications for physical sciences and engineering (PSE) and life sciences (LS) graduates who took postdoctoral positions in government, industry, and academic sectors. We examine postdoc duration, reasons for staying in a postdoc, movement between sectors, and salary implications. There is considerable movement between employment sectors within the first six years post-PhD. Additionally, postdocs in PSE are shorter, better paid, and more often in nonacademic sectors than postdocs in LS. These results can help science and engineering faculty discuss a broader range of career pathways with doctoral students and help new PhDs make better informed early career decisions.
What are the trends in seeking health care for fever in children under-five in Sierra Leone? evidence from four population-based studies before and after the free health care initiative
Authors: Bognini Joel Dofinissery , Samadoulougou Sekou , Ouedraogo Mady , Smart Francis , Kankoye David Tiga , Sankoh Osman , Kirakoya-Samadoulougou Fati
Published: February 2022

Background

In 2010, the government of Sierra Leone implemented the Free Health Care Initiative (FHCI) in the country with the objective of reducing the high maternal, infant, and child mortality rates and improving general health indicators. The objective of this study was to assess the trends in the prevalence of health care-seeking and to identify the determinants of healthcare service utilization by caregivers of children younger than five years.

Methods

The analysis of health-care-seeking behavior was done using data from four population-based surveys in Sierra Leone before (2008) and after (2013, 2016, 2019) the FHCI was implemented. Care-seeking behavior was assessed with regard to caregivers seeking care for children under-five in the two weeks prior to each survey. We compared the percentages of healthcare-seeking behavior change and identify factors associated with healthcare-seeking using a modified Poisson regression model with generalized estimating equations.

Results

In 2008, a total of 1208 children with fever were recorded, compared with 2823 children in 2013, 1633 in 2016, and 1464 in 2019. Care-seeking for children with fever was lowest in 2008 (51%; 95% CI (46.4−55.5)) than in 2013 (71.5%; 95% CI (68.4−74.5)), 2016 (70.3%; 95% CI (66.6−73.8)), and 2019 (74.6%; 95% CI (71.6−77.3)) (p < 0.001). Care-seeking in 2013, 2016 and 2019 was at least 1.4 time higher than in 2008 (p < 0.001) after adjusting for mother’s age, wealth, religion, education level, household head and the child’s age. Care-seeking was lowest for children older than 12 months, mothers older than 35 years, children living in the poorest households, and in the northern region. A trend was observed for the sex of the household head. The level of care-seeking was lowest when the household head was a man.

Conclusions

The increase in healthcare-seeking for children under-five with fever followed the introduction of the FHCI in Sierra Leone. Care-seeking for fever varied by the child’s age, caregiver’s age, household wealth, the sex of the household head and region. Maintaining the FHCI with adequate strategies to address other barriers beyond financial ones is essential to reduce disparities between age groups, regions and, households.