bluuebunny/crossref_metadata_2025 huggingface dataset:
MOTIVAÇÃO NOS LANÇAMENTOS DE OFÍCIO DO ICMS/RJ CONTEMPLANDO PERÍODOS COBERTOS PELA DECADÊNCIA
Authors: Pereira João Luís De Souza
Published: December 2022

Apesar de já estar consolidada a jurisprudência do Superior Tribunal de Justiçaacerca da contagem do prazo decadencial em matéria tributária, a decadência ainda é temaque merece ser revisitado. Os lançamentos de ofício, exigindo ICMS, realizados pelaSecretaria de Fazenda do Estado do Rio de Janeiro não justificam o porquê de não serobservado o art. 150, §4º, do Código Tributário Nacional, quando se referem a fatosgeradores ocorridos há mais de cinco anos da ciência do auto de infração.Consequentemente, a discussão acerca do afastamento do art. 173, I, do CTN, inicia comclaro prejuízo ao direito de defesa do contribuinte. Daí, o porquê de se investigar anecessidade de o lançamento de ofício conter todas as informações úteis para o plenoexercício do direito de defesa pelo contribuinte no âmbito de um processo administrativojusto. 10.12957/rfd.2021.61605
O DOMINÓ COMO RECURSO NA ADAPTAÇÃO DO ENSINO DA MATEMÁTICA NA SÍNDROME DE DOWN
Authors: Vieira Gabriela Cristina , Ribeiro Junior Paulo César , Silva Gleice Eugênia da , Carvalho Maria Fernanda De Faria
Published: December 2022

As Políticas Nacionais de Educação Especial encaminham-se para a necessidade e a importância da inclusão de alunos com deficiência na garantia do direito à educação. Dentre as deficiências e os transtornos globais do desenvolvimento, destacamos a Síndrome de Down (SD). A SD é conhecida pelo atraso cognitivo e motor do indivíduo, fazendo-se necessária a utilização de recursos pedagógicos adaptados desde a infância. Por este motivo, há a necessidade de um material pedagógico adaptado voltado para o desenvolvimento cognitivo de crianças com Síndrome de Down no campo do Lógico-Matemático. Utilizando-se de aportes teóricos como Piaget (1976, 1978) e Oliveira (2017), para respaldar a criação do recurso didático, foi desenvolvido o dominó multifuncional, composto por 28 peças retangulares divididas em duas partes: uma apresentando as operações de adição ou subtração e a outra com o resultado de alguma das operações com imagens do cotidiano das crianças. O material proposto pode acrescentar tanto no desenvolvimento da criança, pois desenvolve o raciocínio lógico, quanto na sua curiosidade, além de estimular sua capacidade de interação social, destacada pela Base Nacional Comum Curricular (2017) como algo a ser tratado com muito cuidado e atenção frente à SD. A elaboração de materiais didáticos adaptados pode ser de fácil acesso por utilizar elementos cotidianos, além de possibilitarem a inclusão, havendo um favorecimento no desenvolvimento escolar do indivíduo.
ACESSIBILIDADE NA CIBERCULTURA: USOS DO AUDIOVISUAL COMO DISPOSITIVO DE INCLUSÃO DE SURDOS NA PANDEMIA
Authors: Colacique Rachel Capucho , Gonçalves Leonardo Conceição , Amaral Mirian Maia do
Published: December 2022

O presente texto objetiva pensar ações, usos e exemplos de conteúdo audiovisual acessível para surdos. Compreendendo a cultura contemporânea como perpassada pelo universo da Cibercultura (LEMOS, 2003; LEVY, 1999; SANTOS, 2014), das redes sociais da internet, dos dispositivos e indivíduos hiperconectados (TAVARES, 2020), faz-se necessário garantir o acesso a todos. Nesse aspecto, é importante destacar que o ambiente cibercultural se constitui também como espaço de lutas e empoderamentos, em que se busca, cada vez mais, a garantia de acesso à internet como um direito humano básico. A pandemia do Coronavírus, que restringiu a circulação de pessoas, e fez com que os inúmeros eventos que antes aconteceriam de maneira presencial, passassem a ser realizados remotamente, acabou por contribuir favoravelmente à produção de conteúdos audiovisuais acessíveis. É nesse contexto que se desenvolve o levantamento documental aqui apresentado. Por meio de uma pesquisa documental descritiva na cibercultura, observou-se e buscou-se materiais audiovisuais com acessibilidade para surdos. Como resultado, destacamos que, embora não exista um modelo único e pré-definido que garanta efetivamente a acessibilidade, contribuem elementos como o tamanho da janela, a sinalização adequada ao perfil do público-alvo, a possibilidade de inclusão de intérpretes surdos e a possibilidade de planejamento prévio à execução (em oposição à inserção posterior da janela de tradução) permitindo assim uma integração maior com a cena ou layout desejado. Para demonstrar os resultados, foram elencados dados que procuraram evidenciar exemplos mais, ou menos, favoráveis no sentido de garantir acesso efetivo ao conteúdo apresentado.
TECNOLOGIA ASSISTIVA: ATENDIMENTO EDUCACIONAL ESPECIALIZADO DE ALUNOS COM AUTISMO NA PANDEMIA
Authors: Ribeiro Joane Lopes , Lustosa Ana Valéria Marques Fortes
Published: December 2022

Este artigo é resultado de caminhos investigativos da dissertação de mestrado. O trabalho pedagógico com crianças que apresentam autismo envolve, em alguns casos, o uso de Tecnologia Assistiva (TA) com o intuito de possibilitar o processo de ensino e aprendizagem, assim como para o aprimoramento das habilidades. De modo geral, observa-se que esse trabalho vem sendo desenvolvido por professores de Atendimento Educacional Especializado (AEE). Nesse sentido, a pesquisa teve por objetivo investigar o uso da TA por professores de AEE com crianças com autismo no contexto da pandemia. Os objetivos específicos estão vinculados aos estudos sobre TA e o AEE de alunos com autismo na pandemia e a aplicabilidade do trabalho pedagógico do professor de educação especial. A pesquisa possui natureza bibliográfica e os resultados evidenciaram que o trabalho pedagógico com alunos com autismo na pandemia e a adoção de TA e de recursos pedagógicos tornaram-se mais um desafio para os professores de educação especial pela limitação de tempo, espaço e interação com os alunos com autismo; a omissão por parte do legislador brasileiro e a ausência de políticas afirmativas que assegurem condições equitativas de ensino e aprendizagem em ambientes remoto por todo o país e, por fim, o cenário atual de pós-pandemia assinalou as disparidades socioeconômicas e regionais de oferta e garantia de educação remota entre as instituições escolares públicas e privadas por todo país.
A meeting of marvellous minds
Authors: Blant Jane , Ashmore Louise
Published: December 2022

An insight into a blossoming relationship between the older and younger generation is provided for us by Jane and Louise. They share how their relationship with Maple Mews has grown, the reflections which have been developed along the way so far, and snippets of the wonderful interactions observed
Enclosing and enveloping play
Authors: Grimmer Tamsin
Published: December 2022

Many children enjoy playing hide and seek or squeezing into small spaces. I have combined both enclosing and enveloping play together in this article because there is often an overlap between different behaviours we observe and these types of schematic play.
When I studied at Pen Green Children's Centre
Authors: Berridge Samantha
Published: December 2022

Former Pen Green student Samantha Berridge reflects on their time completing both their Foundation Degree and BA (Hons) at Pen Green from 2016-2019.
The history of penicillin
Authors: Winter George
Published: December 2022

As new developments reveal new properties, George winter reflects on penicillin's continued reassessment, reflecting on how both humanities and sciences can work together to bring further progress still
Antipsychotics and emotionally unstable personality disorder: a literature review
Authors: Loader Katie
Published: December 2022

Introduction

This reviews aim was to explore the evidence base for the use of antipsychotic medications in the management of acute symptoms in patients with emotionally unstable personality disorder.

Methods

Relevant databases and grey literature were searched for relevant papers. Inclusion/exclusion criteria were applied which resulted in the retrieval of eight papers pertinent to the literature review. The papers were critically appraised, and a thematic analysis was undertaken to collate relevant data.

Findings

Five themes emerged from this literature review: different outcome measures, symptom domains (anger, impulsivity, mood instability, pseudopsychotic symptoms, self-harm and suicidal behaviours, adverse effects, the quality of the evidence and bias).

Conclusions

The evidence base is not robust enough to allow conclusions to be drawn. Any positive results must be weighed up against the potential for adverse events. This review lays the foundations for further research, which is needed to explore antipsychotic treatment.
Influenza vaccines: an introduction
Authors: Greener Mark
Published: December 2022

Seasonal influenza is a leading cause of severe respiratory infections and deaths. Type A influenza can cause severe respiratory disease, death and pandemics. Influenza B accounts for about a quarter of the annual number of seasonal flu cases, but does not cause pandemics. Influenza C viruses cause mild symptoms in humans. Evidence suggests Influenza D does not cause disease in humans. During an influenza infection, the immune system produces inflammatory mediators, which are largely responsible for the systemic symptoms and complications. Vaccines remain the most effective way to prevent influenza-related respiratory disease and non-respiratory complications despite antivirals. Numerous studies support the benefits of influenza vaccination, especially in high-risk groups. However, the effectiveness of the influenza vaccine varies markedly depending on the match between the circulating strains and those in the vaccine, and the recipient's characteristics. Influenza vaccines are, in general, well-tolerated. Research could lead to more effective and, potentially, universal influenza vaccines.
SGLT2 inhibitors in type 2 diabetes: time to flozinate?
Authors: Davies Claire
Published: December 2022

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, sometimes also referred to as ‘gliflozins’ or ‘flozins’, are an established class of medications used for the treatment of insufficiently controlled type 2 diabetes. This article provides a summary of everything nursing staff in primary care need to know about the use of SGLT2 inhibitors for type 2 diabetes to support safe prescribing, monitoring and use.
Mathematic Creative Thinking Processes Through Mind-Mapping Based Aptitude Treatment Interaction Learning Model: A Mixed Method Study
Authors: Kartono Gunawan*, , Kartono Kartono , Wardono Wardono , Kharisudin Iqbal
Published: December 2022

This study aims 1) to determine the effectiveness of the Mind-Mapping based Aptitude Treatment Interaction model towards creative thinking and 2) to explain the mathematical creative thinking process based on the creative level. The number of participants was 26 students who took the Multivariable Calculus course in the odd semester of 2020/2021. This research used the mixed-concurrent embedded method. The data collection techniques were validation, observation, creative thinking tests, and interviews. The results showed that 1) the Mind-Mapping based Aptitude Treatment Interaction model was effective in developing creative thinking, as indicated by the average creative thinking score of the experimental class, which was higher than the control class and 2) the characteristics of students mathematical creative thinking process varied following the creative thinking levels. The students mathematical creative thinking level consists of not creative (CTL 0), less creative (CTL 1), quite creative (CTL 2), creative (CTL 3), and very creative (CTL 4). Students at the CTL 2, CTL 3, and CTL 4 can meet the aspects of fluency, flexibility, and originality.
KAPSAM VE YÖNTEM ÇERÇEVESİNDE TÜRKİYE’DEKİ ÇOCUK FOLKLORU ÇALIŞMALARI
Authors: ÇETİN Nagihan
Published: December 2022

Bilimsel çalışmalarda sistematize etme gereksinimiyle sınıflandırmalar yapılırken halkbilimi alanındaki bu sınıflandırmalardan biri olan çocuk folkloru, en kapsamlı şekliyle çocuğun merkezde olduğu kültürel çalışmalar olarak düşünülebilir. Çocuk folklorunun ne olduğu kadar nasıl çalışıldığı ve çalışılması gerektiği de önem taşır. Bu çerçevede yapılan bu çalışmanın evrenini Türkiye’deki çocuk folkloru çalışmaları oluştururken örneklem çocuk folkloru ismiyle hazırlanmış lisansüstü tezlerden seçilmiştir. Çalışmanın temel problemi incelenen çalışmalarda çocuğun konumunun ne olduğudur. Söz konusu çalışmaların kapsamı ile bu çalışmalarda kullanılan yöntemler, kültürün hangi alanlarının çalışmalara konu edildiği, derleme yapılan kaynak kişilerin seçiminde kullanılan kriterler ve bu kriterlerin çocuk folkloru için ne derece uygun olduğu; bu çalışmalarda kültür içerisinde çocuğun etkin olduğu alanlara mı odaklanıldığı yoksa çocuğun bir nesne konumuna indirgenerek pasif olarak yer aldığı alanlara mı ağırlık verildiği soruları çalışmanın alt problemlerini oluşturmaktadır. Literatür taramasına dayalı içerik analizleri çalışmanın yöntemini oluştururken; çalışma neticesinde söz konusu çalışmalarda çoğu zaman çocuğun aktif değil pasif, özne değil nesne olarak konumlandırıldığı, çalışmaların kültürün belirli alanlarına odaklandığı, kullanılan yöntemlerin, kaynak kişi belirleme kriterlerinin çocuk merkezli çalışmalar için yeterli olmadığı çıkarımına varılarak daha sonra yapılabilecek çalışmalar için çocuk folkloru çalışmalarının kapsam ve yöntemine ilişkin önerilerde bulunulmuştur.
A 21-Year-Old Woman with Suspecting Gitelman Syndrome
Authors: Denny Berty , Agung Prabowo Nurhasan , Puspa Putri Desy , Myrtha Risalina , Apriningsih Hendrastutik
Published: December 2022

Introduction: Gitelman syndrome (GS), is a hereditary condition marked by a specific kidney function impairment. GS symptoms do not normally manifest until beyond the age of six years. We present a rare case of a 21-year-old woman with a background in generalized weakness muscle cramps with tetany, fever, and dyspnea.  The goal of this study is to give a case report of Gitelman syndrome suspicion.

Result: Gitelman syndrome is identified through clinical indicators and lab testing, such as low potassium and magnesium levels in the blood, metabolic alkalosis, and low calcium levels in the urine. We do a variety of physical and laboratory tests to determine the disease and rule out other possibilities. Molecular proof is difficult to get due to a lack of resources and the high expense of genetic testing, which has become one of our case report's flaws. This patient was diagnosed as suspecting Gitelman syndrome and treated for electrolyte imbalances. The patients were given replacement therapy, which comprised intravenous potassium, sodium, and chloride therapy, as well as calcium therapy. In addition, we also provided some symptomatic therapy. She was discharged five days later in fine condition.

Conclusion : This is one of the few reports of a 21-year-old lady being suspected of having Gitelman syndrome (GS). We conduct a battery of physical and laboratory tests to diagnose the disease and rule out other possibilities. We provide the appropriate therapies in accordance with the guidelines, and the outcomes are favorable.
Housing conditions and long-term care needs of older adults in Ghana: Evidence from the WHO SAGE Ghana Wave 1
Authors: Awuviry-Newton Kofi , Abekah-Carter Kwamina , Ofori-Dua Kwadwo , Gyasi Razak M. , Newton Cindy Nhyira , Agyemang-Duah Williams , Kowal Paul , Dintrans Pablo Villalobos
Published: December 2022

The present study examined the association between housing conditions and long-term care needs of older adults in Ghana. We used data from 4,920 adults aged ≥50 years that participated in the World Health Organisation’s (WHO) Study on adult health and AGEing Ghana Wave 1. Housing conditions were assessed with drinking water, sanitation, cooking conditions and building materials, and long-term care needs were based on WHO Disability Assessment Schedule 2.0. Multivariable logistic regressions modelled the effect of housing conditions on long-term care needs. After full adjustment for all available potential confounders, older adults living in households with unimproved cooking conditions had higher odds of reporting long-term care needs (OR = 6.87, 95%CI: 5.04–9.37) compared to those in improved cooking condition households. Moreover, those in households with unimproved housing materials (OR = 1.27, 95%CI: 1.01–1.72) and those in unimproved sanitation households (OR = 1.26, 95%CI: 1.05–1.54) were more likely to experience long-term care needs after respectively controlling for demographic and health-related covariates. Poor housing conditions are risk factors of long-term care needs in Ghana. Efforts to improve housing conditions may benefit older age functional abilities and unmet long-term care needs.
Estimating the economic cost of carbapenem resistant Enterobacterales healthcare associated infections in Singapore acute-care hospitals
Authors: Cai Yiying , Hoo Grace S. R. , Lee Winnie , Tan Ban Hock , Yoong Joanne , Teo Yik-Ying , Graves Nicholas , Lye David , Kwa Andrea L.
Published: December 2022

Quantifying the costs of hospital associated infections (HAIs) caused by carbapenem-resistant Enterobacterales (CRE) can aid hospital decision makers in infection prevention and control decisions. We estimate the costs of a CRE HAI by infection type and the annual costs of CRE HAIs to acute-care hospitals in Singapore. We used tree diagrams to estimate the costs (in Singapore dollar) of different CRE HAI types from the health service perspective and compared them to the costs of carbapenem-susceptible HAIs. We used two approaches to estimate costs–direct costs of consumables for infection prevention and treatment; and costs associated with lost bed days. Cost of a HAI were extrapolated to annual CRE HAI incidence in Singapore acute-care hospitals to estimate the annual cost to the hospitals. We found that the cost of a CRE HAI based on direct cost and lost bed days are SGD$9,913 (95% CI, SGD$9,431–10,395) and SGD$10,044 (95% CI, SGD$9,789–10,300) respectively. CRE HAIs are markedly higher than the carbapenem-susceptible HAIs for all infection types. In both approaches, CRE pneumonia was the costliest infection. Based on a CRE HAI incidence of 233 per 100,000 inpatient admissions, CRE HAIs costed SGD$12.16M (95% CI, SGD$11.84–12.48M) annually based on direct costs, and SGD$12.33M (95% CI, SGD$12.01–12.64M) annually based on lost bed days. In conclusion, we described the cost of CRE HAIs in Singapore hospitals and identified infections with the highest costs. The findings may be useful in informing future economic evaluations of competing CRE HAI prevention and treatment programmes.
Risk of suicide ideation in comorbid substance use disorder and major depression
Authors: Onaemo Vivian N. , Fawehinmi Timothy O. , D’Arcy Carl
Published: December 2022

Background

Suicidal behaviour is commonly associated with major depression (MD) and substance use disorders (SUDs). However, there is a paucity of research on risk for suicide ideation among individuals with comorbid SUDs and MD in the general population.

Objectives

This study investigated the associated risk of suicide ideation in comorbid SUDs—cannabis use disorder (CUD), alcohol use disorder (AUD), drug use disorder (DUD) with major depressive episode (MDE) in a nationally representative sample.

Methods

Multilevel logistic regression models were used to analyze the 2012 Canadian Community Health Survey- Mental Health (CCHS-MH) data. This is a cross-sectional survey of nationally representative samples of Canadians (n = 25,113) aged 15 years and older residing in the ten Canadian provinces between January and December 2012. Diagnoses of MDE, AUD, DUD, and CUD were based on a modified WHO-CIDI, derived from DSM-IV diagnostic criteria.

Results

Comorbidity was found to be the strongest predictor of suicide ideation. Compared to those with no diagnosis of either a SUD or MDE, individuals with a comorbid diagnosis of AUD with MDE, CUD with MDE, or DUD with MDE were 9, 11 and 16 times more likely to have 12-month suicide ideation respectively. A diagnosis of MDE was a significant predictor of 12-month suicide ideation with about a 7-fold increased risk compared with individuals not diagnosed with either MDE or a SUD.

Conclusion

Suicide is a preventable public health issue. Our study found a significantly increased risk of suicide ideation among persons who have comorbid SUD with MD. Effective integration of mental health and addictions services could mitigate the risk of suicide and contribute to better outcomes.
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Authors: Gilmore Sarah A. , Tam Danny , Cheung Tara L. , Snyder Chelsea , Farand Julie , Dick Ryan , Matles Mike , Feng Joy Y. , Ramirez Ricardo , Li Li , Yu Helen , Xu Yili , Barnes Dwight , Czerwieniec Gregg , Brendza Katherine M. , Appleby Todd C. , Birkus Gabriel , Willkom Madeleine , Kobayashi Tetsuya , Paoli Eric , Labelle Marc , Boesen Thomas , Tay Chin H. , Delaney William E. , Notte Gregory T. , Schmitz Uli , Feierbach Becket
Published: December 2022

Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenetic modifiers to identify potential inhibitors of replication or gene expression. From this work we identified isonicotinic acid inhibitors of the histone lysine demethylase 5 (KDM5) with potent anti-HBV activity. To enhance the cellular permeability and liver accumulation of the most potent KDM5 inhibitor identified (GS-080) an ester prodrug was developed (GS-5801) that resulted in improved bioavailability and liver exposure as well as an increased H3K4me3:H3 ratio on chromatin. GS-5801 treatment of HBV-infected primary human hepatocytes reduced the levels of HBV RNA, DNA and antigen. Evaluation of GS-5801 antiviral activity in a humanized mouse model of HBV infection, however, did not result in antiviral efficacy, despite achieving pharmacodynamic levels of H3K4me3:H3 predicted to be efficacious from the in vitro model. Here we discuss potential reasons for the disconnect between in vitro and in vivo efficacy, which highlight the translational difficulties of epigenetic targets for viral diseases.
Using runaway replication to express polyhydroxyalkanoic acid (pha) genes from a novel marine bacterium in enteric bacteria: The influence of temperature and phasins on PHA accumulation
Authors: Kolibachuk Dana , Ryder Benjamin J. , Lyons Edward R. , Woolsey Ariel , Lopes Margaret K. , Thakkar Keya , Pacheco Nunez Mayelin , Duquenoy Michaela , Valente Nevan R. , Nieves Ashley
Published: December 2022

While plastics have revolutionized our world, plastic waste has serious environmental and economic impacts. Polyhydroxyalkanoic acid (PHA) is a bacterial carbon and energy reserve shown to be both biodegradable and biocompatible and could potentially replace conventional plastics. However, cost-effective mass production remains elusive. Bacteria often accumulate PHA as cytoplasmic granules. PHA synthase creates the PHA polymer from acetoacyl-CoA monomers, while phasins are small multifunctional proteins that are found in abundance on the granule surface. The PHA synthase gene from a novel marine isolate, Vibrio B-18 (or B-18), was placed in the presence or absence of an upstream phasin gene in a runaway replication plasmid using polymerase chain reaction (PCR) technology. Plasmid gene expression may be induced chemically or thermally. Overexpression of the PHA genes was demonstrated by SDS-PAGE analysis, and microscopy was used to detect PHA accumulation in three different enteric bacteria (Escherichia coli, Klebsiella aerogenes, and Shigella flexneri). While the B-18 genes were clearly overexpressed at 41°C, PHA accumulation occurred more readily at the lower (30°C) non-inducing temperature regardless of chemical induction if the phasin gene was present. A mutational analysis confirmed the identity of the start codon for the PHA synthase gene and provided evidence supporting the requirement for phasins to allow for PHA accumulation in the recombinant hosts. The findings described in this study confirm the conclusions obtained from related studies from other laboratories and lend support to the importance of including a phasin gene in addition to the basic genes needed for PHA synthesis and accumulation in recombinant enteric bacteria, such as Escherichia coli, Klebsiella aerogenes, and Shigella flexneri.
High prevalence of antimicrobial resistance and multidrug resistance among bacterial isolates from diseased pets: Retrospective laboratory data (2015–2017)
Authors: Haulisah Nurul Asyiqin , Hassan Latiffah , Jajere Saleh Mohammed , Ahmad Nur Indah , Bejo Siti Khairani
Published: December 2022

Laboratory surveillance and the monitoring of antimicrobial resistance (AMR) trends and patterns among local isolates have been highly effective in providing comprehensive information for public health decision-making. A total of 396 cases along with 449 specimens were received for antibiotic susceptibility testing at a public university veterinary diagnostic laboratory in Malaysia between 2015 and 2017. Escherichia coli was the most frequently isolated (n = 101, 13%) bacteria, followed by Staphylococcus pseudintermedius (n = 97, 12%) and Streptococcus canis (n = 62, 8%). In cats, S. pseudintermedius isolates were highly resistant to azithromycin (90%), while the E. coli isolates were highly resistant to doxycycline (90%), tetracycline (81%), and cephalexin (75%). About 55% of S. pseudintermedius and 82% of E. coli were multi-drug resistant (MDR). In dogs, S. intermedius isolates were highly resistant to aminoglycosides neomycin (90.9%) and gentamicin (84.6%), and tetracycline (75%). Whereas the E. coli isolates were highly resistant to cephalexin (82.1%) and amoxicillin/clavulanic acid (76.5%). MDR was observed in 60% of S. intermedius and 72% of E. coli from dogs. Generally, the bacterial isolates from cats demonstrated higher levels of resistance to multiple antibiotics compared to those from dogs.
Confounds and overestimations in fake review detection: Experimentally controlling for product-ownership and data-origin
Authors: Soldner Felix , Kleinberg Bennett , Johnson Shane D.
Published: December 2022

The popularity of online shopping is steadily increasing. At the same time, fake product reviews are published widely and have the potential to affect consumer purchasing behavior. In response, previous work has developed automated methods utilizing natural language processing approaches to detect fake product reviews. However, studies vary considerably in how well they succeed in detecting deceptive reviews, and the reasons for such differences are unclear. A contributing factor may be the multitude of strategies used to collect data, introducing potential confounds which affect detection performance. Two possible confounds are data-origin (i.e., the dataset is composed of more than one source) and product ownership (i.e., reviews written by individuals who own or do not own the reviewed product). In the present study, we investigate the effect of both confounds for fake review detection. Using an experimental design, we manipulate data-origin, product ownership, review polarity, and veracity. Supervised learning analysis suggests that review veracity (60.26–69.87%) is somewhat detectable but reviews additionally confounded with product-ownership (66.19–74.17%), or with data-origin (84.44–86.94%) are easier to classify. Review veracity is most easily classified if confounded with product-ownership and data-origin combined (87.78–88.12%). These findings are moderated by review polarity. Overall, our findings suggest that detection accuracy may have been overestimated in previous studies, provide possible explanations as to why, and indicate how future studies might be designed to provide less biased estimates of detection accuracy.
Obesity in children and adolescents and the risk of ovarian cancer: A systematic review and dose‒response meta-analysis
Authors: Ding Nan , Zhan Junyi , Shi Youjin , Qiao Tianci , Li Panpan , Zhang Tingting
Published: December 2022

Objective

The relationship between obesity in children and adolescents and the risk of ovarian cancer remains controversial. The aim of this meta-analysis was to explore the exact shape of this relationship.

Methods

We conducted dose‒response meta-analyses of cohort and case‒control studies, including published studies derived from searches in the PubMed, Embase, Web of Science and Cochrane Library databases until October 2022. Pooled effect size estimates are expressed as relative risks (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) and were evaluated by fixed-effect models. A nonlinear dose‒response meta-analysis was performed by using a restricted cubic spline model.

Results

After screening 4215 publications, 10 studies were included in the present meta-analysis. Overall analyses revealed statistically significant associations of obesity in children and adolescents with ovarian cancer (adjusted RR = 1.19, 95% CI: 1.11 to 1.28, P < 0.001). Moreover, the association was consistently significant in most subgroup analyses, for example, using geographic stratification, the results remained stable both in the Americas(RR = 1.11; 95% CI: 1.01 to 1.21; P = 0.022) and Europe (RR = 1.46; 95% CI: 1.21 to 1.77; P<0.001). For the dose‒response analyses, the risk of ovarian cancer increased with the degree of obesity, and the trend increased rapidly when body mass index (BMI) was over 25.95 kg/m2.

Conclusion

Our findings indicate that obesity in children and adolescents is a risk factor for ovarian cancer, and the risk increases with increasing BMI.
Catquest-9SF questionnaire: Validation in a Greek-speaking population using Rasch analysis
Authors: Nanos Panagiotis , Kouteliari Vasiliki , Panagiotopoulou Eirini-Kanella , Papadopoulos Nikolaos , Ntonti Panagiota , Labiris Georgios
Published: December 2022

Purpose

The Catquest-9SF questionnaire is a tool measuring visual disability and vision-related limitation in patients’ daily activities. The primary objective of this study was the validation of Catquest-9SF in a Greek-speaking cataract population.

Methods

The questionnaire was translated into Greek and translated back into English. A pre-final Greek version was formed and tested by 10 Greek-English bilingual participants and by the translation team, and the final version was produced. Patients scheduled for cataract surgery completed the questionnaire preoperatively and postoperatively. Rasch analysis was performed for the assessment of the Catquest-9SF psychometric properties, including response category ordering, item fit statistics, principal components analysis, precision, differential item functioning and targeting for preoperative and postoperative data collectively.

Results

A total of 100 (55 men, 45 women, mean age = 71.94±6.63) cataract patients completed the Greek version of Catquest-9SF questionnaire preoperatively and postoperatively. Rasch analysis showed a significant improvement in the median person Rasch score from −1.49 preoperatively to −4.71 logits postoperatively, while the effect size was 1.3. Unidimensionality was confirmed since infit and outfit mean square values varied between 0.66 and 1.37. Rasch analysis showed good precision and separation ability (Person Separation Index of 3.28, and Person Reliability of 0.92). Four response categories were found for all items. The item-person means difference was -1.83 logits. The difference between preoperative and postoperative Catquest-9SF logit score was positively correlated with preoperative Catquest-9SF logit score (coeff. = 0.798, p<0.0001) and negatively correlated with postoperative spherical equivalent (coeff. = -0.825, p = 0.011).

Conclusion

The Greek version of Catquest-9SF proved to be reliable, valid, unidimensional and responsive to changes after cataract surgery presenting good psychometric properties for cataract patients. Some postoperative mistargeting was found indicating that the tasks were easily performed by respondents after cataract surgery.

Trial registration

NCT05323526 -retrospectively registered.
Market Power in Manufacturing and Services Industries
Authors: Mesquita Leonor , Carreira Carlos , Martins Rita
Published: December 2022

This study analyzes the extent of the market power of the manufacturing and services industries in Portugal over the last decade. The results show that Portuguese industries are mostly operating under imperfect competition. Mark-ups are heterogeneous across industries, with services having higher mark-ups on average than manufacturing. The apparel and the administrative activities industries have the highest mark-ups; in turn, the food and the beverages industries have the lowest mark-ups, while the rubber and plastics industry seems to operate under competitive conditions. There is therefore room for improving product market competition in Portugal.
The Role of Different Types of Creditors on Zombie Firm Creation
Authors: Carreira Carlos , Lopes Joana
Published: December 2022

Despite the key role of trade creditors as sources of finance, the literature on their impact on the proliferation of zombie firms is rare. This study examines whether suppliers, such as banks, engage in “evergreen” lending to zombie firms and whether their behavior differs from that of banks. We found that highly productive, larger and younger firms are less likely to become zombie firms. The behavior of suppliers is, in fact, different from that of banks; they are indeed more cautious in lending to zombie firms. Unlike suppliers, banks seem to have contributed to the rise of resource misallocation, a key explanation for the productivity slowdown in the new century.
Rosemary (Salvia rosmarinus): Health-Promoting Benefits and Food Preservative Properties
Authors: Veenstra Jacob P. , Johnson Jeremy
Published: December 2022

Natural food preservatives in the form of herb extracts and spices are increasing in popularity due to their potential to replace synthetic compounds traditionally used as food preservatives. Rosemary (Salvia rosmarinus) is an herb that has been traditionally used as an anti-inflammatory and analgesic agent, and currently is being studied for anti-cancer and hepatoprotective properties. Rosemary also has been reported to be an effective food preservative due to its high anti-oxidant and anti-microbial activities. These properties allow rosemary prevent microbial growth while decreasing food spoilage through oxidation. Rosemary contains several classes of compounds, including diterpenes, polyphenols, and flavonoids, which can differ between extracts depending on the extraction method. In particular, the diterpenes carnosol and carnosic acid are two of the most abundant phytochemicals found in rosemary, and these compounds contribute up to 90% of the anti-oxidant potential of the herb. Additionally, several in vivo studies have shown that rosemary administration has a positive impact on gastrointestinal (GI) health through decreased oxidative stress and inflammation in the GI tract. The objective of this review is to highlight the food preservative potential of rosemary and detail several studies that investigate rosemary to improve in vivo GI health.
Evaluation of A Nutrition Feeding Algorithm for Children and Adolescents Undergoing Haematopoietic Stem Cell Transplantation (HSCT)
Authors: Bartle Jodie , McJannet Elise , Whitehead Natalie T , Gilbertson Heather
Published: December 2022

Background
Nutrition support during the acute phase post allogeneic haematopoietic stem cell transplantation (HSCT) is required to optimise short- and long-term outcomes for children. An algorithm was developed and evaluated to assist clinicians to make objective and consistent enteral feeding decisions.

Methods
The algorithm was evaluated on all patients who underwent allogeneic HSCT treatment between November 2017 - February 2019.

Results
Of the 48 patients, 43 had a nasogastric tube (NGT) inserted, of which 36 patients received a hydrolysed peptide-based formula, 5 patients received a whole protein formula only and 2 patients were fed an amino acid-based formula. Parenteral nutrition (PN) was used in 41 of the patients. Eleven did not have an NGT in-situ at the commencement of HSCT. Of the remaining 37 patients, 26 followed the algorithm and 11 patients did not comply. The group of patients who did not follow the algorithm had the longest median length of stay (LOS) of 49 days. Patients receiving only EN had the lowest median LOS of 30 days. The two groups that reported better weight outcomes were those who followed the algorithm and those who were fully EN fed.

Conclusions
Effective use of the HSCT feeding algorithm indicated improved patient outcomes for children undergoing HSCT, with better weight outcomes and reduced LOS. Recommendations to improve the efficacy and compliance of the algorithm include regular education/input to the oncology medical teams to better understand objective thresholds for EN and PN commencement.
Variant Trifurcation of the Ulnar Nerve in Guyon’s Canal of the Human Wrist: Case report
Authors: Fathi Ali Tagreed , Fadlelmula Khalid Musa
Published: December 2022

During routine dissection of the right hand of a 52-year-old Asian descent male cadaver in the Department of Anatomy at Jazan University-Faculty of Medicine, we observed an anatomical variation of the ulnar nerve (UN). There was a trifurcation of the nerve in the ulnar tunnel proximal to the pisiform bone. An awareness of such variation may be of great clinical importance despite the presence of trifurcation of the ulnar nerve, which does not usually cause symptoms but becomes important in the evaluation of entrapment neuropathy and during surgical and orthopedic interventions
Marginal SARS-CoV-2 Spike Protein Increases Interferon and Balances Cytokine Gene Expression
Authors: Das Satadal , Chatterjee Debasmita , Paira Krishnendu
Published: December 2022

Some evidence confirms the paradoxical beneficial role of harmful antigens when used in highly diluted forms. In this experiment, we observed cytokine gene expression changes in Gallus gallus embryo after challenge with Delta SARS-CoV-2 RBD spike protein antigen, from a concentration of 10 µg/mL to a series of highly diluted forms in ethanol, along with controls. We have also studied pre-and post- experimental combined sets of higher (10 µg/mL) and significantly lower antigen concentrations (attogram level). Attogram and zeptogram level concentrations of the antigen showed consistently remarkable up-regulation of INF-α among different cytokine gene expressions. INF-β gene expressions at the zeptogram level of the antigen showed consistent changes, although not so outstanding. The pre-experimental set having attogram level antigen administered first, followed by a 10µg/mL antigen challenge, showed excellent cytokine balance. Other experimental groups, including the control sets, showed variable results at different concentrations.
Tempos de Convergência: o perfil digital do jovem universitário da UFAC
Authors: Drever Aleta Tereza , Gobbi Maria Cristina
Published: December 2022

Resumo
Os blogs e a democratização do campo da moda
Authors: Bon Olga
Published: December 2022

Este artigo tem como temática principal blogs de moda bem-sucedidos, no que tange questões midiáticas, financeiras e de audiência, a partir de um olhar que busca refletir sobre a democratização do acesso ao campo da moda, uma vez que a expansão dessas plataformas é freqÃ¼entemente relacionada ao avanço de um possível interesse de parte da sociedade por temáticas ligadas ao mundo fashion . Isto se deve, muito em parte, pelo forte crescimento midiático que os blogs do segmento tiveram nos últimos anos. Através deste trabalho, pretende-se apresentar um panorama atual sobre esses ambientes digitais, pensando até que ponto blogs com o perfil analisado realmente proporcionaram a democratização do campo da moda. Para isso, será apresentado um panorama mais geral em relação ao status atual que os blogs de moda bem-sucedidos conseguiram promover. Mais adiante, levantaremos o estado da arte dos estudos relacionados a blogs de moda, para, finalmente, apresentarmos reflexões sobre a indagação proposta.
Metal na Véia: modo de usar Interação entre fãs de Heavy Metal em um fórum de discussão online
Authors: Lemos D
Published: December 2022

O objetivo deste trabalho é investigar os modos de utilização do fórum Metal na Véia2, comunidade virtual de discussão sobre o estilo de música Heavy Metal. A página, criada e administrada por brasileiros, foi inaugurada em dezembro de 2002 e permanece ativa até hoje, contando com mais de dois mil e setecentos membros registrados. Entendendo, assim como Miller e Slater (2001), que a Internet não é um ambiente virtual monolítico e descontextualizado, mas sim um conjunto de diferentes tecnologias que são utilizadas por diferentes pessoas em diferentes locais do mundo, desejamos investigar, entre outros aspectos, os motivos que levam os membros a utilizar essa plataforma, o tipo de interação que procuram e se essa interação permanece restrita ao ambiente virtual do fórum ou é expandida para outras plataformas.
O Marketing das Produções Musicais das Bandas Gaúchas e Catarinenses de Pop e Rock na Atualidade
Authors: Hawerroth William Victor , Vailati André Luiz
Published: December 2022

Partindo da situação atual do cenário fonográfico onde as novas tecnologias estão transformando os hábitos de consumo de música em suportes físicos e digitais, este estudo exploratório analisa a divulgação das produções musicais de bandas de pop e rock na atualidade. Com base na evolução do mercado fonográfico exposta em Anderson (2006), nas essências da comunicação de marketing em Kotler, Kartajaya e Setiawan (2010) e Crescitelli e Shimp (2012), e no desempenho do marketing na era digital em Jenkins (2006), Gabriel (2010) e Longo (2014), foram entrevistados os responsáveis pela comunicação e estratégias mercadológicas de três bandas de dois estados do Sul do Brasil. Por uma de análise de conteúdo, a investigação traz percepções acerca do marketing nos ambientes virtuais através de um relacionamento mais próximo com os consumidores
A Ingerência da Empresa Transnacional na Escola Pública por Meio da sua Articulação com o Estado / The Transnational Company's Mismanagement in Public School Through its Articulation with the State
Authors: Pires Joelma Lúcia Vieira
Published: December 2022

Pesquisa qualitativa sobre a ingerência da empresa na escola pública por meio da sua articulação com o Estado. O estudo foi realizado em uma escola da rede estadual de São Paulo localizada em um município da Região Metropolitana. Realizamos entrevistas com professores da instituição, uma vez que eles são responsáveis por desenvolver o material "pedagógico" (kit) da empresa na sala de aula. O projeto da empresa foi desenvolvido na escola por meio da sua articulação com o Ministério da Educação (MEC) no Governo Fernando Henrique Cardoso e no Governo Lula. Portanto, ambos estabeleceram articulação com o setor privado nas políticas para a Educação escolar pública. Verificamos que o desenvolvimento do kit da empresa na escola atinge a prática pedagógica e autonomia dos professores, pois eles utilizam o referido material "pedagógico" nas suas aulas. Em função disso, os conteúdos das disciplinas são subjugados ao projeto "educativo" da empresa. Embora predomine a tendência de os professores viabilizarem o material "pedagógico" da empresa nas suas aulas, existem alguns que questionam tal material e resistem na tentativa de reafirmarem a sua autonomia e a formação dos estudantes para a emancipação. No entanto, tais questionamentos e resistências são individuais, não evidenciam práticas de fortalecimento coletivo.ABSTRACT: Qualitative research about transnational company's mismanagement in public school through its articulation with the State. The study was realized in a state school in Sao Paulo, located in a city of the Metropolitan Area. Interviews with the institution's teachers were accomplished since they are responsible for developing the "pedagogical" material (kit) of the company in the classroom. The company's project was developed in the school by the means of articulation with the Education Ministry (MEC) in Fernando Henrique Cardoso's government and Lula's government. Therefore, both established articulations with the private sector in politics for public scholar education. It was verified that the kit's development of the company in school reaches the pedagogical practice and the teacher's autonomy once they use that "pedagogical" material in their classes. As a result, the discipline's content is subjugated to the "educative" project of the company. Although there is a predomination in the teacher's tendency to turn the company's "pedagogical" material available in classes, there are some that question such material and resist, trying to reaffirm their autonomy and the student's formation to their emancipation. However, such questions and resistances are individual, they do not show practices of collective empowerment.
Gestão Democrática da Escola e Participação / School of Management and Democratic Participation
Authors: Souza Silvana Aparecida de
Published: December 2022

Trata-se de texto sobre o caráter necessariamente democrático de uma educação que se proponha emancipadora. Porém, considerando que não existe um conceito unívoco de democracia, foi necessário conceituar o que se denominou de democracia representativa e de democracia participativa. A partir da constatação de que com o esgotamento do último período de ditadura militar no Brasil implantou-se a democracia representativa, percebe-se que esse modelo orienta hegemonicamente a gestão das escolas, já que essa instituição não está "descolada" da sociedade em geral. No entanto, ao refletir sobre as experiências concretas de gestão das escolas públicas no país, constata-se que por vezes essa instituição é ainda mais autoritária do que as demais. O texto aponta para a necessidade da construção de relações de "partilha de poder" com vistas a superação da democracia meramente representativa, refletindo sobre a possibilidade de tencionar as relações intra escolares com vistas à construção da democracia participativa.ABSTRACT: This text is about the character necessarily democratic of an education that proposes empowering. However, considering that there is a univocal concept of democracy, was necessary to conceptualize what is called representative democracy and participatory democracy. From the observation that with the exhaustion of the last period of military dictatorship in Brazil implemented to representative democracy, it is clear that this hegemonic model guides the management of schools, since this institution is not "cool" of society in general. However, reflecting on the concrete experiences of management of public schools in the country, it appears that this institution is sometimes even more authoritative than the others. The text points out the necessity of building relations of "power sharing" with a view to overcoming the purely representative democracy, reflecting on the possibility of tense the relations within the school towards the construction of participatory democracy.