bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing medication assisted treatment in rural primary care practice: a qualitative comparative analysis from IT MATTTRs Colorado
Authors: Holtrop Jodi Summers , Mullen Rebecca , Curcija Kristen , Rubinson Claude , Westfall John M. , Nease Donald E. , Zittleman Linda
Published: October 2024

Purpose

Opioid dependence and use disorders (OUDs) are serious public health crises resulting in a rising number of opioid-related deaths. Medication assisted treatment (MAT), in this case treatment with buprenorphine, is an evidence-based solution to combatting OUD; however, MAT has been largely unavailable in rural areas. This study investigated what it took to increase MAT in rural Colorado primary care practices.

Methods

Mixed methods study using qualitative and quantitative data collected from interviews, observations, surveys, and practice-reported data. Participants were staff members from 35 rural primary care practices in Colorado, United States. We qualitatively analyzed the data, then transformed the data, then analyzed it using qualitative comparative analysis (QCA).

Results

Having a MAT waivered prescribing clinician on staff and a MAT system in place were necessary conditions to providing MAT (consistency = 1.0; coverage = 0.53 & 0.39 respectively). Practice size (number of providers) was associated with differences in conditions that provided sufficient aspects for MAT provision. Small (1–2 medical providers), non-private practices benefited from the presence of behavioral health and a clinician with MAT experience. Medium sized practices (3–5 providers) whether private or not benefited from behavioral health, often in combination with a clinician with MAT experience. In large practices (6 or more providers), behavioral health was not a factor while having a clinician with MAT experience mattered half of the time.

Conclusion

Implementation of MAT in rural primary care is a complex task that may benefit from the resources of behavioral health and a clinician with prior MAT experience.
Long-term COVID-19 sequelae by Theta and SARS-CoV-2 variants in a Philippine cohort
Authors: Saloma Cynthia P. , Ayes Marc Edsel C. , Taracatac Paolo S. , Asa Meryl Rose Q.
Published: October 2024

Introduction

Millions have been infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) since its emergence in 2019, but most patients make a full recovery. The long-term consequences of the infection are anticipated to unravel in the succeeding years with reports of patients experiencing chronic, debilitating sequelae post-infection commonly referred to as Long COVID. Various Variants of Concern (VoCs) have emerged as the SARS-CoV-2 virus evolved displaying increased infectivity and immune evasiveness. We investigate whether the infecting VoCs affect the sequelae of Long COVID in a Philippine cohort.

Methods

SARS-CoV-2 cases confirmed using RT-PCR followed by Next Generation Sequencing were identified from selected regions of the Philippines and recruited through a retrospective-prospective cohort design. Participants were divided based on the initial infecting VoC or Variant of Interest (VoI) and were subsequently interviewed regarding the presence, intensity, and frequency of key Long COVID symptoms, and followed up on two more separate sessions at least three (3) months apart for a total of three (3) data collection points (S1, S2, S3) to document changes in symptoms throughout the year-long study period.

Results

Long COVID symptoms were reported in 88, 82, and 68% of participants in S1, S2, and S3, respectively, showing declining incidence with elapsed time since the first reported infection. General symptoms including headache, fatigue, and post-exertional malaise were the most frequently reported symptoms, while neuropsychiatric symptoms were the second most frequently reported symptoms. In all three (3) sessions, intermittent brain fog, fatigue, and headache were the most frequently reported symptoms in all SARS-CoV-2 variant cohorts. Factors such as age, sex, comorbidities, and disease severity influenced symptom frequency, providing insight into the risk factors that contribute to the prevalence of this disease.

Conclusion

A large proportion (>68%) of cases in this Philippine cohort previously infected with different SARS-CoV-2 variants presented with long-term complications of COVID-19 characterized by a highly heterogeneous set of debilitating symptoms. The study highlights the need for long-term monitoring of Long COVID and its impact on human health and the need for our health systems to adopt policy response strategies.
Developing an interprofessional identity complementary to a professional identity - findings related to Extended Professional Identity Theory (EPIT)
Authors: Reinders Jan Jaap , Başer Kolcu Mukadder İnci , Kolcu Giray
Published: October 2024

Collaboration among various professions often faces barriers owing to divergent perspectives, priorities, and expertise shaped by distinct socialization processes. These differences can hinder effectiveness, efficiency, and workforce well-being. The Extended Professional Identity Theory (EPIT) addresses this issue by fostering an interprofessional identity without weakening professional identities. Drawing from psychological theories, EPIT explains the coexistence of interprofessional and professional identities, and predicts associated behaviors. It also emphasizes the importance of combining interprofessional identity formation with developing interprofessional competencies and adapting to environmental factors to achieve synergy in (temporary or permanent) mixed profession groups. Introduced in 2018, EPIT research initially relied on the measurement of congruent interprofessional behaviors as indirect indicators of interprofessional identity that could not yet be measured. An experiment demonstrated that enhancing social identification in mixed profession groups with interprofessional assignments reduced the social hierarchy within 6 h across three meetings. The 2020 development of the Extended Professional Identity Scale (EPIS) confirmed interprofessional identity as a three-dimensional social construct. So far, several scientific studies have supported many propositions of EPIT. These propositions are related to dimensionality and various psychometric properties, cross-cultural similarities, evidence and clues for interprofessional identity formation, and its predictive validity in interprofessional education and collaborative practice. Türkiye is among several countries (e.g., the Netherlands, Belgium, Germany, Lithuania, Finland, and Indonesia) where EPIT-based interprofessional identity is being investigated. To illustrate contextual differences and their potential cross-cultural implications, it is valuable to explore how interprofessional identity adds value in the Turkish context. This approach facilitates understanding the regional implications of interprofessional identity, including interprofessional education initiatives, increased university engagement, the development of measurement instruments, challenges and future directions, and national and international collaborations. This paper aims to explain and clarify EPIT propositions compared to other theories, describe current evidence, and outline future research directions, with a focus on developments within the Turkish context as a showcase.
Novel, cold-adapted D-laminaribiose- and D-glucose-releasing GH16 endo-β-1,3-glucanase from Hymenobacter siberiensis PAMC 29290, a psychrotolerant bacterium from Arctic marine sediment
Authors: Kim Do Young , Lee Yung Mi , Lee Jong Suk , Chung Chung-Wook , Son Kwang-Hee
Published: October 2024

Endo-β-1,3-glucanase is a glycoside hydrolase (GH) that plays an essential role in the mineralization of β-glucan polysaccharides. In this study, the novel gene encoding an extracellular, non-modular GH16 endo-β-1,3-glucanase (GluH) from Hymenobacter siberiensis PAMC 29290 isolated from Arctic marine sediment was discovered through an in silico analysis of its whole genome sequence and subsequently overexpressed in Escherichia coli BL21. The 870-bp GluH gene encoded a protein featuring a single catalytic GH16 domain that shared over 61% sequence identity with uncharacterized endo-β-1,3-glucanases from diverse Hymenobacter species, as recorded in the National Center for Biotechnology Information database. The purified recombinant endo-β-1,3-glucanase (rGluH: 31.0 kDa) demonstrated peak activity on laminarin at pH 5.5 and 40°C, maintaining over 40% of its maximum endo-β-1,3-glucanase activity even at 25°C. rGluH preferentially hydrolyzed D-laminarioligosaccharides and β-1,3-linked polysaccharides, but did not degrade D-laminaribiose or structurally unrelated substrates, confirming its specificity as a true endo-β-1,3-glucanase without ancillary GH activities. The biodegradability of various substrate polymers by the enzyme was evaluated in the following sequence: laminarin > barley β-glucan > carboxymethyl-curdlan > curdlan > pachyman. Notably, the specific activity (253.1 U mg–1) and catalytic efficiency (kcat/Km: 105.72 mg–1 s–1 mL) of rGluH for laminarin closely matched its specific activity (250.2 U mg–1) and kcat/Km value (104.88 mg–1 s–1 mL) toward barley β-glucan. However, the kcat/Km value (9.86 mg–1 s–1 mL) of rGluH for insoluble curdlan was only about 9.3% of the value for laminarin, which correlates well with the observation that rGluH displayed weak binding affinity (< 40%) to the insoluble polymer. The biocatalytic hydrolysis of D-laminarioligosaccharides with a degree of polymerization between 3 and 6 and laminarin generally resulted in the formation of D-laminaribiose as the predominant product and D-glucose as the secondary product, with a ratio of approximately 4:1. These findings suggest that highly active rGluH is an acidic, cold-adapted D-laminaribiose- and D-glucose-releasing GH16 endo-β-1,3-glucanase, which can be exploited as a valuable biocatalyst for facilitating low temperature preservation of foods.
Application of machine learning based genome sequence analysis in pathogen identification
Authors: Gao Yunqiu , Liu Min
Published: October 2024

Infectious diseases caused by pathogenic microorganisms pose a serious threat to human health. Despite advances in molecular biology, genetics, computation, and medicinal chemistry, infectious diseases remain a significant public health concern. Addressing the challenges posed by pathogen outbreaks, pandemics, and antimicrobial resistance requires concerted interdisciplinary efforts. With the development of computer technology and the continuous exploration of artificial intelligence(AI)applications in the biomedical field, the automatic morphological recognition and image processing of microbial images under microscopes have advanced rapidly. The research team of Institute of Microbiology, Chinese Academy of Sciences has developed a single cell microbial identification technology combining Raman spectroscopy and artificial intelligence. Through laser Raman acquisition system and convolutional neural network analysis, the average accuracy rate of 95.64% has been achieved, and the identification can be completed in only 5 min. These technologies have shown substantial advantages in the visible morphological detection of pathogenic microorganisms, expanding anti-infective drug discovery, enhancing our understanding of infection biology, and accelerating the development of diagnostics. In this review, we discuss the application of AI-based machine learning in image analysis, genome sequencing data analysis, and natural language processing (NLP) for pathogen identification, highlighting the significant role of artificial intelligence in pathogen diagnosis. AI can improve the accuracy and efficiency of diagnosis, promote early detection and personalized treatment, and enhance public health safety.
Topographic anatomy of the lateral surface of the parietal lobe and its relationship with white matter tracts
Authors: Oğlin Volkan , Orhun Ömer , Quiñones-Hinojosa Alfredo , Middlebrooks Erik H. , Çevik Orhun Mete , Usseli M. İmre , Güdük Mustafa , Aksoy M. Emin , Pamir M. Necmettin , Bozkurt Baran
Published: October 2024

Aim of this study was to define sulcal and gyral variations of the lateral parietal cortex and underlying white matter tracts and emphasize the importance of relationship between topographic anatomy of parietal lobe and white matter tracts underlying it in approaches to deep parietal and atrial lesions. Twenty-eight formalin-fixed cerebral hemispheres of 14 adult cadavers were used. Ten hemispheres were dissected from lateral to medial by fiber dissection and all stages were photographed. Our anatomic findings were supported by MRI tractography. Postcentral sulcus and intraparietal sulcus were continuous in most of the cadavers (71% in right, 64% in left side). Intermediate sulcus of Jensen was in bayonet shape in 86 and 50 percent of cadavers at right and left side, respectively. The range of perpendicular distance between the meeting point and interhemispheric fissure was 2.5–4.9 cm in right and 2.8–4.2 cm in left hemisphere whereas the range of distance between meeting point and the sylvian fissure was 3–6 cm and 2.5–5.6 in left and right hemispheres, respectively. When the meeting point was located more laterally, the probability of damaging the arcuate fasciculus and superior longitudinal fasciculus II during dissection was increased. We also found that the intraparietal sulcus and intermediate sulcus of Jensen were associated with the superior longitudinal fasciculus II, middle longitudinal fasciculus, inferior frontooccipital fasciculus, tapetum, and optic radiation. These variations and their relation to subcortical tracts should be considered in atrium and deep parietal lobe surgeries.
Exploring core and bridge symptoms in patients recovering from stroke: a network analysis
Authors: Huang Yao , Cao Songmei , Li Teng , Wang Jingjing , Xia Zhuoran
Published: October 2024

Background

Patients recovering from stroke experience a variety of symptoms that present as a synergistic and mutually reinforcing “symptom cluster,” rather than as singular symptoms. In this study, we researched and systematic analyzed these symptom clusters, including core and bridge symptoms, to help determine the relationships between symptoms and to identify key symptom targets, providing a new approach for formulating precise symptom management interventions.

Methods

Convenience sampling was applied to select 432 stroke recovery patients treated in the Seventh People’s Hospital of Changzhou City from August 1, 2023 to April 14, 2024. Subsequently, a cross-sectional survey was conducted using the General Information Questionnaire and Stroke Symptom Experience Scale to extract symptom clusters via exploratory factor analysis. Finally, the “qgraph” and “bootnet” packages in the R language were used to construct a network layout to describe the relationships between symptoms and calculate the centrality index.

Results

The average age of the 432 enrolled recovering stroke patients was 68.17 ± 12.14 years, including 268 males (62.04%) and 164 females (37.96%), none of whom underwent surgical intervention. Among this cohort, the 3 symptoms with the highest incidence rates were “limb weakness” (A2, 80.56%), “fatigue” (A5, 77.78%), and “limitations of limb movement” (A1, 68.06%). A total of 5 symptom clusters were extracted: the somatic activity disorder, mood-disorder-related, cognitive–linguistic dysfunction, somatic-pain-related, and foot dysfunction symptom clusters. In the symptom network, the 2 most common symptoms in terms of intensity and expected impact were “fatigue” (A5, rs = 1.14, re = 1.00) and “pessimism about the future” (B3, rs = 1.09, re = 1.02). The symptom with the strongest bridge intensity was “limb pain” (D1, rs = 2.64).

Conclusion

This study uses symptom network analysis to explore the symptoms of stroke patients during recovery, identifying core symptoms and bridge symptoms. Based on these findings, we can develop more targeted management plans to improve the accuracy and efficiency of interventions. Through this management approach, we can enhance treatment effectiveness, reduce unnecessary medication, lower adverse drug reactions, and optimize the allocation of medical resources.
Management for lymphatic malformations of head and neck
Authors: Yang Weijia , Wang Huaijie , Xie Chong , Lin Weilong , Wang Peihua , Guo Zhengtuan
Published: October 2024

Background

To explore the management of lymphatic malformation in head and neck.

Methods

This is a retrospective study at a single center. Data on demographic, surgery, sclerotherapy and follow-up information were collected from our Vascular Anomalies Center database. Patients with lymphatic malformation of head and neck who had undergone surgery and sclerotherapy between March 2020 and March 2024 were included.

Results

There were 94 patients in this study, the lesion sites included head (n = 60), tongue (n = 7), neck (n = 41), pharynx (n = 7), and head and neck (n = 7). Symptoms included bleeding (n = 6), infection (n = 2), dyspnea (n = 2), dysphonia (n = 4), and dysphagia (n = 4). Lymphatic malformation included macrocystic (n = 61), microcystic (n = 12) and mixed (n = 21). Surgeries for LM included radical resection, subtotal or partial resection and staged surgeries. Sclerotherapies included bleomycin monotherapy and combined sclerotherapy with ethanol and bleomycin, under ultrasound or fluoroscopy guidance. The follow-up period was from 3 months to 1 year. The therapeutic effect was evaluated according to the size of the treatment area. 55 patients, 21 patients, 11 patients and 7 patients were evaluated with excellent, good, moderate and no response, respectively.

Conclusion

Surgical resection, sclerotherapy and the combination of the two are efficacious treatment modalities for head and neck LM. Combined with oral drugs and other new therapies may be warranted in future for challenging conditions.
Global prevalence of fatigue in patients with multiple sclerosis: a systematic review and meta-analysis
Authors: Yi Xiaodong , Zhang Yue , Du Qiufeng , Kang Jing , Song Shuang , Li Tao , Jiang Yunlan
Published: October 2024

Background

Fatigue is one of the most common and burdensome symptoms for patients with multiple sclerosis (PwMS), considerably impacting their quality of life and employment. Numerous reports have described the prevalence of MS-related fatigue, but there is no global consensus on this matter.

Objective

To examine the global prevalence of MS-related fatigue and identify sources of heterogeneity in the published literature.

Methods

A systematic review and meta-analysis were conducted. A comprehensive search of the PubMed, EMBASE, Cochrane Library, Web of Science, PsycINFO, CINAHL, China National Knowledge Infrastructure (CNKI), and Wanfang database for potential literature from 2000 to January 31, 2024. A random effects model was used to calculate the prevalence of MS-related fatigue. Subgroup analyses and a meta-regression were used to explore the sources of heterogeneity.

Results

Sixty-nine studies from 27 countries were included. The global prevalence of MS-related fatigue was 59.1%, and it has decreased every decade since 2000. Fatigue was prevalent among females, those with lower education levels, those who were older, those with greater disability, and those with longer MS durations. The meta-regression revealed that fatigue measurement instruments were the largest source of heterogeneity.

Conclusion

The prevalence of MS-related fatigue is quite high. Healthcare professionals should screen for and manage fatigue for PwMS as early as possible and pay attention to populations with a high prevalence of fatigue. The high heterogeneity among the prevalence rates due to differences in the fatigue scales suggests the importance of reaching a consensus on the best screening tools for MS-related fatigue.
Temporal and spatial analysis of event-related potentials in response to color saliency differences among various color vision types
Authors: Takahashi Naoko , Sawayama Masataka , Chen Xu , Motomura Yuki , Takeichi Hiroshige , Miyauchi Satoru , Hiramatsu Chihiro
Published: October 2024

Introduction

Human color vision exhibits significant diversity that cannot be fully explained by categorical classifications. Understanding how individuals with different color vision phenotypes perceive, recognize, and react to the same physical stimuli provides valuable insights into sensory characteristics. This study aimed to identify behavioral and neural differences between different color visions, primarily classified as typical trichromats and anomalous trichromats, in response to two chromatic stimuli, blue-green and red, during an attention-demanding oddball task.

Methods

We analyzed the P3 component of event-related potentials (ERPs), associated with attention, and conducted a broad spatiotemporal exploration of neural differences. Behavioral responses were also analyzed to complement neural data. Participants included typical trichromats (n = 13) and anomalous trichromats (n = 5), and the chromatic stimuli were presented in an oddball paradigm.

Results

Typical trichromats exhibited faster potentiation from the occipital to parietal regions in response to the more salient red stimulus, particularly in the area overlapping with the P3 component. In contrast, anomalous trichromats revealed faster potentiation to the expected more salient blue-green stimulus in the occipital to parietal regions, with no other significant neural differences between stimuli. Comparisons between the color vision types showed no significant overall neural differences.

Discussion

The large variability in red-green sensitivity among anomalous trichromats, along with neural variability not fully explained by this sensitivity, likely contributed to the absence of clear neural distinctions based on color saliency. While reaction times were influenced by red-green sensitivity, neural signals showed ambiguity regarding saliency differences. These findings suggest that factors beyond red-green sensitivity influenced neural activity related to color perception and cognition in minority color vision phenotypes. Further research with larger sample sizes is needed to more comprehensively explore these neural dynamics and their broader implications.
FAS gene expression, prognostic significance and molecular interactions in lung cancer
Authors: Li Kaimin , Tan Shing Cheng , Yang Zhihao , Li Chenwei
Published: October 2024

Introduction

FAS has been implicated in the development of various cancers, but its involvement in lung cancer has not been systematically characterized. In this study, we performed data mining in online tumor databases to investigate the expression, methylation, alterations, protein interactions, co-expression and prognostic significance of FAS in lung cancer.

Method

The expression, prognostic significance and molecular interactions of FAS in lung cancer was mined and analyzed using GENT2, GEPIA2, UALCAN, cBioPortal, STRING, GeneMANIA, UCSC Xena, Enrichr, and OSluca databases. FAS expression was subsequently investigated at the protein level in samples from 578 lung cancer patients to understand its protein-level expression. In vitro validation of FAS gene expression was performed on H1299, H1993, A549 and HBE cell lines.

Result

We found that the expression of FAS was significantly downregulated in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) compared to normal lung tissue. In addition, we observed a higher level of FAS promoter methylation in LUSC tissue than in normal tissue. FAS alterations were rare (1.9%) in lung cancer samples, with deep deletions being more common than missense mutations, which occurred mainly in the TNFR-like cysteine-rich domain and the death domain. We also identified a list of proteins interacting with FAS and genes co-expressed with FAS, with LUAD having 11 co-expressed genes and LUSC having 90 co-expressed genes. Our results also showed that FAS expression has limited prognostic significance (HR=1.302, 95% CI=0.935-1.139, P=0.530). Protein level investigation revealed that FAS expression varied among individuals, with nTPM values ranging from 5.2 to 67.2.

Conclusion

This study provides valuable insights into the involvements and characteristics of FAS in lung cancer. Further studies are needed to investigate the clinical significance of FAS alterations in lung cancer and to explore the potential of targeting FAS for therapeutic intervention.
Praziquantel resistance in schistosomes: a brief report
Authors: Eastham Gabriela , Fausnacht Dane , Becker Matthew H. , Gillen Alan , Moore William
Published: October 2024

Schistosomiasis is a group of both acute and chronic parasitic trematode infections of the genus Schistosoma. Research into schistosomiasis has been minimal, leading to its classification as a neglected tropical disease, yet more than 140 million people are infected with schistosomes globally. There are no treatments available for early-stage infections, schistosomal dermatitis, or Katayama syndrome, other than symptomatic control with steroids and antihistamines, as the maturing organisms seem to be mostly resistant to typical antiparasitics. However, praziquantel (PZQ) has been the drug of choice for schistosomiasis for decades in the latter stages of the disease. Though it is effective against all three clinically relevant species, heavy reliance on PZQ has led to concerns of schistosome resistance, especially in areas that have implemented this drug in mass drug administration (MDA) programs. This article summarizes the available literature concerning the available evidence for and against a warranted concern for PZQ resistance, genomic studies in schistosomes, proposed mechanisms of resistance, and future research in alternative methods of schistosomiasis treatment.
Tanshinone IIA delays liver aging by modulating oxidative stress
Authors: Liu Qi , Li Xu , Luo Yi
Published: October 2024

Organ-specific aging is increasingly recognized for its research significance, with liver aging demonstrating particular relevance due to its central role in metabolism. We have pioneered the discovery that the expression of ESRRG in the liver positively correlates with age and have established its association with clinical characteristics, including hepatic edema. Our findings link liver aging to a shift in oxidative stress states, where ESRRG, a crucial nuclear receptor responsive to oxidative stress, may be modulated by various small molecules. Through virtual screening of a natural medicinal molecule database followed by further validation, we confirmed that the natural compound Tanshinone IIA mitigates oxidative stress-induced damage in the liver via the ESRRG/Cyp2e1 pathway, thus decelerating liver aging. Importantly, our study also explores the dynamic impact of Tanshinone IIA on ESRRG conformation, providing a profound understanding of its molecular interactions with ESRRG and laying a foundation for the rational design of small molecules based on natural compounds.
Morality through the lens of Confucian heritage countries: collective self variations and moral worldviews
Authors: Takamatsu Reina , Park Joonha , Matsuo Akiko
Published: October 2024

The issue of Western, Educated, Industrialized, Rich, and Democratic (WEIRD) samples dominating research has been ongoing for decades, and now the emerging trend is to turn to theoretical perspectives from the Majority World. Adopting Western-centric methods based on reductionism can overlook important details and differences between similar cultures, particularly in East Asian cultures, where the Confucian values of relational harmony take many forms. We discuss a novel theoretical perspective on moral constitutions in Confucian heritage cultures. Our central tenet is that divergent moral concepts and ideals are present in Confucian cultures because each culture emphasizes a specific pillar and the self is situated differently in the social relationships that define the scope of interpersonal moral obligations. We consider three Confucian countries: China, Japan, and South Korea as examples. Despite geographical proximity and conventional categorization in cultural psychology, each Confucian country manifests distinct patterns of the self, moral ideals, and behavior in socio-moral contexts. To understand how and why moral worldviews vary within a region, we need to examine how the self in socio-cultural contexts differs and guides interpersonal norms and behaviors across sociocultural contexts. We conclude this paper by offering methodological recommendations for including indigenous moral concepts outside the WEIRD context.
Moderating effect of sleep quality in the relationship between coping and distress among medical students
Authors: Perveen Shahida , Malik Najma Iqbal , Rehman Muhammad Ebad ur , Khan Muhammad Younas , Rehan Syeda Tayyaba , Asghar Muhammad Sohaib , Pakpour Amir H. , Griffiths Mark , Ullah Irfan , Atta Mohsin
Published: October 2024

Introduction

The present study examined the moderating effects of sleep quality in the relationship between coping and distress among medical college students. Present study was conducted to ensure the mental health of medical students and to dig out the reasons behind their disturbed health which can directly impact their performance at work.

Methods

The study utilized a cross-sectional survey and was distributed to students at various medical institutions in the Punjab province of Pakistan from October 2019 to June 2020. The sample comprised 369 participants (120 males; 32.5%). The survey included the Pittsburgh Sleep Quality Index (PSQI), Kessler Scale of Psychological Distress (K10), Brief Cope Scale, and Wong and Law Emotional Intelligence Scale.

Results

The results showed there was a significant relationship between coping and distress. More specifically, adaptive coping and distress were negatively associated (r=-.24), and maladaptive coping and distress were positively associated (r=.46). Moreover, the present study found that poor sleep quality was a significant positive predictor of distress. Moderation analysis showed that sleep quality was a significant moderator in the relationship between adaptive coping and distress (ΔR2=.011, β=-.36, p<.01) as well as between maladaptive coping and distress (ΔR2=.021, β=-.17, p<.01).

Conclusion

The study’s findings clearly showed that sleep quality is a significant moderator in the relationship between coping (both adaptive and maladaptive) and distress among medical students.
Barriers and facilitators to dissemination of non-communicable diseases research: a mixed studies systematic review
Authors: Renda Ana , Turon Heidi , Lim Michelle , Wolfenden Luke , McCrabb Sam , O’Connor Seán R. , Finch Meghan , Smith Natasha , Goraya Navdeep , Harrison Cheryce L. , Naughton Shaan , Grady Alice , Hodder Rebecca , Reilly Kathryn , Yoong Serene
Published: October 2024

Background

There is a large number of research studies about the prevention of non-communicable diseases (NCD), with findings taking several years to be translated into practice. One reason for this lack of translation is a limited understanding of how to best disseminate NCD research findings to user-groups in a way that is salient and useful. An understanding of barriers and facilitators to dissemination is key to informing the development of strategies to increase dissemination. Therefore, this review aims to identify and synthesise the barriers and facilitators to dissemination of NCD research findings.

Methods

A mixed studies systematic review was performed following JBI (formerly known as Joanna Briggs Institute) methodology. The search included articles from January 2000 until May 2021. We conducted a comprehensive search of bibliographic and grey literature of five databases to identify eligible studies. Studies were included if they involved end-users of public health research that were decision-makers in their setting and examined barriers/facilitators to disseminating research findings. Two pairs of reviewers mapped data from included studies against the Framework of Knowledge Translation (FKT) and used a convergent approach to synthesise the data.

Results

The database search yielded 27,192 reports. Following screening and full text review, 15 studies (ten qualitative, one quantitative and four mixed methods) were included. Studies were conducted in 12 mostly high-income countries, with a total of 871 participants. We identified 12 barriers and 14 facilitators mapped to five elements of the FKT. Barriers related to: (i) the user-group (n = 3) such as not perceiving health as important and (ii) the dissemination strategies (n = 3) such as lack of understanding of content of guidelines. Several facilitators related to dissemination strategies (n = 5) such as using different channels of communication. Facilitators also related to the user-group (n = 4) such as the user-groups’ interest in health and research.

Conclusion

Researchers and government organisations should consider these factors when identifying ways to disseminate research findings to decision-maker audiences. Future research should aim to build the evidence base on different strategies to overcome these barriers.

Systematic review registration

The protocol of this review was deposited in Open Science Framework (https://doi.org/10.17605/OSF.IO/5QSGD).
Epidemiological characterization of human infection with H5N6 avian influenza
Authors: Li Fengying , Sun Zhou , Tao Mingyong , Song Kai , Wang Zhe , Ren Xiaobin
Published: October 2024

Background

In recent years, there have been frequent reports of human infection with H5N6 avian influenza. However, the fundamental characteristics of the disease remain unclear. This paper conducts a systematic review to explore the epidemiological features of the disease, aiming to provide a foundation for epidemic prevention and control and to serve as a reference for clinical diagnosis.

Method

A systematic search was performed in PubMed, Web of Science, CNKI, Wanfang and gray literature up to November 15, 2023. All articles were about the epidemic features of the H5N6 subtype of avian influenza, written in English or Chinese.

Results

This review encompasses 24 documented outbreaks of human H5N6 avian influenza, exclusively reported in southern China. The age range of cases spanned from under 2 years old to 81 years old. The incubation period ranged from 1 to 13 days, with a mean of 4.3 days. Among the 24 cases, 22 individuals had a documented history of contact with poultry. Of the 23 cases with available prognosis data, 12 resulted in fatalities, yielding a significant fatality rate of 52.2%. A noteworthy observation is that all cases with a history of contact with sick and dead poultry resulted in fatalities, and the difference in fatality rates between this group and others was statistically significant (χ2 = 7.441, p = 0.014). This study identified a total of 888 close contacts, none of whom demonstrated infection.

Conclusion

This study represents a comprehensive summary of the epidemiological characteristics of human H5N6 avian influenza. Significantly, it sheds light on the incubation period of the disease and underscores a potential elevated risk of mortality among patients with a history of contact with sick and dead poultry.
Healthy lifestyle and HPV infection risk: results from a cross-sectional study
Authors: Zhao Xi , Wu Yue , Hu Huangyu
Published: October 2024

Background

Human Papillomavirus (HPV) infection constitutes a significant global public health challenge despite the widespread implementation of vaccination programs, with infection rates persistently high. Recent studies suggest that lifestyle factors including diet quality (DQ) and physical activity (PA) could play a pivotal role in the mitigation of HPV infections. This investigation explored the influence of DQ, PA, and a healthy lifestyle on the incidence of HPV infection in adult women.

Methods

Data from 5,308 women aged 20–59 from the National Health and Nutrition Examination Survey (NHANES) 2007–2016. DQ and PA were measured using the Healthy Eating Index (HEI-2015) and the Global Physical Activity Questionnaire (GPAQ), respectively, creating four lifestyle groups based on how well they matched dietary and activity guidelines. The associations between key factors and HPV infection were explored using multivariate logistic regression, trend tests, and interaction tests.

Results

Fully adjusted multivariable logistic regression models revealed an inverse association between the risk of HPV infection and higher levels of PA (OR = 0.914; 95% CI: 0.854–0.979) as well as DQ (OR = 0.993; 95% CI: 0.989–0.998). Individuals in the highest tertile of DQ displayed a reduced risk of HPV infection relative to those in the lowest tertile (OR = 0.846; 95% CI: 0.726–0.986). Belonging to the third quintile of PA was linked to a lower risk of HPV infection than the lowest quintile (OR = 0.823; 95% CI: 0.681–0.995). Subgroups adhering to a healthy DQ were linked to a lower risk of HPV infection irrespective of PA meeting guideline recommendations.

Conclusion

Our findings underscore the importance of a healthy diet in conjunction with appropriate PA in preventing HPV infection, offering new insights for public health policies and interventions.
Peculiarities in household solid waste management in Nigeria: a quick review
Authors: Fakunle Sunday Olutayo
Published: October 2024

Evidence abounds to indicate the prevalence of indiscriminate disposal of household solid waste as a practice in Nigeria. This practice contributes to green crime and jeopardizes public health. Therefore, the focal point of several academic papers has been household solid waste management. The objective of the current study was to make a rapid review on practices that scholars have recommended for household members to take proper care of their waste made of paper, cellophane, plastic, metal and wooden material and the peculiarities of these recommended practices in Nigeria with implications for waste management practices in developing countries worldwide. The study adopted the systematic review method to explore findings in the available relevant studies that were published within the years 2017 and 2023 to depict the current situations of the study’s subject matter in Nigeria. The current study sorted out these findings into themes. The review pinpointed several recommended practices such as zero-waste policy, waste minimization/reduction, and various disposal methods to manage the household solid waste and the major factors responsible for the setbacks these practices have faced. The review further highlighted gaps in existing studies which could form the basis for prospective studies on household solid waste management.
Animal health as a function of farmer personality and attitude: using the HEXACO model of personality structure to predict farm-level seropositivity for Fasciola hepatica and Ostertagia ostertagi in dairy cows
Authors: Leinmueller Markus , Adler Friedemann , Campe Amely , Knubben-Schweizer Gabriela , Hoedemaker Martina , Strube Christina , Springer Andrea , Oehm Andreas W.
Published: October 2024

Introduction

Infections with Fasciola hepatica and Ostertagia ostertagi impinge upon dairy cow health and welfare and represent a major economic factor in livestock industry. Control measures largely rely on the use of anthelminthic drugs. However, reports of anthelmintic resistance necessitate sustainable approaches. Farmer characteristics such as attitude and personality are crucial for the implementation of control strategies and on-farm practices.

Methods

In the present study, the HEXACO (Honesty-Humility, Emotionality, eXtraversion, Agreeableness, Conscientiousness, Openness to experience) model of personality structure, which conceptualizes human personality, was used to evaluate the relationship of farmer aspects with on-farm bulk tank milk seropositivity for F. hepatica and O. ostertagi. Moreover, information on farm structure, housing, management, and farmers’ attitude was collected in a face-to-face interview. Farm-level seropositivity for F. hepatica and O. ostertagi was predicted via elastic net regression.

Results

Out of 193 farms housing 8,774 cows in the German Federal State of Bavaria, 47 farms (24.4%) were seropositive for F. hepatica, 77 farms (39.9%) for O. ostertagi, and 42 farms (21.8%) for both endoparasites. The model for F. hepatica seropositivity selected the covariates pasture access, O. ostertagi seropositivity, higher farmer conscientiousness, and organic farming as relevant predictors. Seropositivity for O. ostertagi was predicted by F. hepatica seropositivity, pasture access, organic farming, and farmers being neutral regarding their satisfaction with animal health on their farm. Higher values for the HEXACO factors extraversion and emotionality were inversely associated with O. ostertagi seropositivity.

Discussion

The present work emphasizes the importance of farmer traits in regard to animal health and parasite occurrence. For the effective acceptance and implementation of sustainable control strategies for livestock helminth infections, it is crucial to consider these aspects to holistically address the challenges of managing parasitic diseases. Moreover, tailored communication strategies can be developed incorporating the understanding of individual stockman characteristics and subsequently ensuring encouragement of stakeholders.
Novel adomavirus associated with proliferative skin lesions affecting the dermal denticles of a sand tiger shark (Carcharias taurus)
Authors: Powell Ashley L. , Camus Alvin C. , Leary John H. , Miller Sarah N. , Bell Cynthia M. , Ng Terry Fei Fan
Published: October 2024

A captive sand tiger shark (Carcharias taurus) presented with progressive, hard, raised, miliary skin lesions localized to the lateral trunk and peduncle. Histopathologic evaluation of biopsy samples revealed dysplastic proliferation of odontogenic epithelium with the production of collagenous material. Inclusion bodies and viral particles were not observed with light or transmission electron microscopy, respectively. However, using next generation sequencing with Illumina MiSeq and PCR followed by Sanger sequencing, the complete genome of a novel adomavirus, tentatively named sand tiger shark adomavirus (STAdoV), was obtained from the affected tissue. The genome was circular and 18.5 kilobases with bidirectionally transcribed genes, namely EO1, EO2 & 4, EO3, LO4, LO5, LO6, LO7, LO8, and SET. In situ hybridization using RNAscope® technology and a STAdoV specific probe localized viral DNA to the nuclei of proliferating epithelial cells. Adomaviruses are an emerging viral group with structural and replicative genes sharing a complex evolutionary history with adenoviruses and small circular DNA tumor viruses including papillomaviruses and polyomaviruses. Adomaviruses are described in a number of fish species in association with both necrotizing and proliferative diseases. BLAST analysis of the viral genome revealed greatest nucleotide identity (71.29%) to guitarfish adomavirus (GAdoV), another elasmobranch virus associated with proliferative (epidermal) skin lesions. Lesions in the index animal persisted for approximately 1 year during which time four conspecifics developed similar proliferations. Ultimately, lesions in all sharks regressed spontaneously without recurrence for 2 years.
Sustainable Spatial Distribution and Determinants of Key Rural Tourism Villages in China: Promoting Balanced Regional Development
Authors: Gao Yanning , Zhang Haozhe , Shi Xiaowen
Published: October 2024

Understanding the spatial distribution and sustainable development of rural tourism is essential for promoting balanced regional growth and formulating optimized policy strategies. This study aims to provide insights into sustainable development and policy optimization. Utilizing geographic information system technology, dominance analysis, and Geodetector statistical methods, this research offers a comprehensive examination of the spatial patterns and determinants of these distributions. The findings reveal significant regional disparities and clustering, with a higher concentration of key villages in economically developed eastern and central regions and fewer in the less developed western regions. The dominance analysis highlights that provinces such as Zhejiang, Shandong, and Beijing demonstrate strong advantages across multiple dimensions, including ecological environment, economic development, tourism infrastructure, transportation accessibility, policy support, and social development. Conversely, regions such as Ningxia, Qinghai, and Tibet exhibit lower dominance scores, indicating challenges in rural tourism development due to limited resources and infrastructure. Key influencing factors include forest coverage, GDP per capita, the number of star-rated hotels, transportation network density, policy initiatives, and urbanization rates. The results underscore the importance of a multi-dimensional approach to enhance rural tourism competitiveness and suggest targeted strategies for underperforming regions. This study contributes to advancing the theoretical framework of sustainable rural tourism and provides actionable insights for policymakers to foster balanced regional development, ecological conservation, and community-centered tourism practices.
PREDICTION OF WEAR BEHAVIOR OF A SLIDING BEARING OF A BALANCER SUSPENSION UNDER DYNAMIC LOADS
Authors:   Orel State University, Rodichev Alekse Yrievich
Published: October 2024

The article presents an approach to constructing a predictive wear model of a highly loaded sliding bearing for the balance suspension of a truck operating under cyclic operating conditions. The analysis of several different wear models showed the greatest relevance of the model based on the law of wear of J.F. Archard. One of the difficulties in using this model is the adequate assessment of the wear coefficient, which is usually determined experimentally and depends on the operating conditions of the friction pair. The developed mathematical model makes it possible to assess the service life of a sliding bearing, taking into account the changing operating conditions of the vehicle during its operation until the next maintenance.
METHODOLOGICAL ASPECTS OF DETERMINING THE LOCATION OF A DISTRIBUTION CENTER BASED ON THE USE OF TIME CRITERIA BY THE METHOD OF FICTITIOUS NODES AND BRANCHES
Authors:   Oryol State University, Novikov Alexander Nikolaevich , Zhestkova Svetlana Anatolievna ,   Penza State University of Architecture and Construction
Published: October 2024

This paper presents the methodological aspects of determining the coordinates of the distribution center. A method has been developed for finding the location of the distribution center according to the time criterion, taking into account the curvature of the route. A numerical example is given based on the proposed methodology.
ASSESSING THE POTENTIAL DANGER OF REGULAR PUBLIC TRANSPOTATION ROUTES
Authors:   Platov South-Russian State Polytechnic University (NPI), Efimov Artem Dmitrievich , Karaeva Marina Ruslanovna ,   Don State Technical University, Alibagandov Alibagand Omarovich ,   Platov South-Russian State Polytechnic University (NPI), Nefedov Viktor Viktorovich ,   Platov South-Russian State Polytechnic University (NPI)
Published: October 2024

The analysis of methods for assessing the potential danger of regular public transport routes, depending on the characteristics of its elements, is carried out. A simplified methodology for assessing the potential danger of bus routes is proposed, characterized by a principled approach to calculating the coefficient of relative accident rate and rapid response when exceeding its maximum permissible values. This approach will make it possible to determine the dynamically changing working conditions of drivers on routes and ensure traffic safety while working on the line.