bluuebunny/crossref_metadata_2025 huggingface dataset:
Double-J Ureteral Stenting in Obstetrics and Gynecology: Pivotal or Problematic?
Authors: Radu Viorel-Dragos , Costache Radu Cristian , Onofrei Pavel , Banov Pavel , Al Jaafari Feras , Vasilache Ingrid-Andrada , Socolov Demetra , Radu Rodica
Published: December 2024

Background and Objectives: Double-J stents are urinary catheters that are frequently used in urology. They are now also used in other specialist areas such as obstetrics and gynecology. However, the use of double-J stents is not without side effects. The aim of this review was to highlight the indications and possible adverse effects of the use of these stents in obstetrics and gynecology. Materials and Methods: We analyzed works published after 1995 in the PUBMED, SCOPUS, and Web of Science databases related to the use of double-J stents in obstetrics and gynecology, as well as reported adverse events. We carried out a narrative review of the available literature on this topic. Results: We identified 69 relevant publications that we included in the review. In obstetrics, indications include the treatment of gestational hydronephrosis, some urological conditions during pregnancy, such as obstructive urinary calculi, with or without superinfection, or intraoperative use for cesarean section or hysterectomy after cesarean section, to protect from, or to solve, ureteral lesions. In gynecology, they are used preoperatively or intraoperatively to protect the ureter during gynecological operations in the pelvic area or postoperatively to repair some ureteral injuries. They are also indicated for ureteral obstructions that occur after pelvic radiotherapy for gynecological neoplasms. Complications associated with the use of double-J stents include more frequent urinary tract infections, lower urinary tract symptoms, calcifications and misplacements. Conclusions: Double-J stents are widely used in obstetrics and gynecology and are characterized by good efficiency and safety, although some side effects may occur (lower urinary tract symptoms, hematuria, complications in birth outcomes), which do not limit their use. Summary of evidence: In this review, we analyzed the indications and complications of double-J ureteral stenting in obstetric and gynecologic patients. We found that the procedure is safe, both in the treatment of ureteral obstruction and in the resolution of postoperative complications. No serious complications of ureteral stenting have been noted that would constitute a contraindication to its use. Future prospective studies in large patient cohorts are necessary to validate our data.
One-Year Outcomes of Trabeculotomy with 120°, 180°, or 360° Schlemm’s Canal Incision for Primary Open-Angle Glaucoma: A Retrospective Study
Authors: Mori Hidetsugu , Kiriishi Tatsunori , Omi Masatoshi , Ohnaka Masayuki , Imai Hisanori
Published: December 2024

Background/Objectives: Primary open-angle glaucoma (POAG), if caused by elevated intraocular pressure (IOP), may require a trabeculotomy (LOT), in which the trabecular meshwork (TM) and Schlemm’s canal (ISC) are incised. However, the association between the incision angle and outcomes remains unclear. Therefore, in this study, we investigated the surgical outcomes of a trabeculotomy combined with cataract surgery in patients with POAG over a 12-month follow-up period. Methods: We included 66 patients (corresponding to 83 eyes) with POAG who underwent trabeculotomy ab externo with a metal probe (M-LOT: 120° incision of the TM and ISC), ab interno with a Kahook Dual Blade® (K-LOT: 180° incision of the TM and ISC), or ab interno with a 5-0 nylon suture (S-LOT: 360° incision of the TM and ISC) between January 2015 and December 2022. We assessed IOP, the percentage reduction from preoperative IOP, the number of IOP-lowering medications taken, the incidence of postoperative complications, and the success rate using Kaplan–Meier survival analysis. Results: The median IOP was significantly lower than the baseline across all three groups. The number of IOP-lowering medications taken was significantly reduced only in the M-LOT group. The mean percentage reduction from the preoperative IOP in the K-LOT group was significantly lower than that in the M and S-LOT groups. Beween those subjected to an ab ineterno LOT, the S-LOT group demonstrated a significantly higher rate of IOP reduction 12 months after the operation compared to the K-LOT group. Kaplan–Meier cumulative survival analyses revealed a lower success rate for the K-LOT group than for the M and S-LOT groups. The M-LOT group had the lowest incidence of hyphema and IOP spikes, whereas the S-LOT group had the highest incidence of these complications. Conclusions: The M-, K-, and S-LOTs had different surgical outcomes during the 12 months of follow-up, with the M-LOT group showing the fewest complications. These results will help in selecting the most suitable trabeculotomy strategy for patients with POAG. Based on the postoperative outcomes of the ab interno K- and S-LOTs, a wider incision of the TM and ISC leads to effective IOP reduction.
Successful Treatment of Unilateral Pulmonary Edema as Minimally Invasive Mitral Valve Surgery Complication—Case Presentation
Authors: Harpa Marius Mihai , Oltean Sânziana Flamind , Al Hussein Hussam , Anitei David Emanuel , Puscas Iulia Alexandra , Bănceu Cosmin Marian , Veres Mihaly , Opriș Diana Roxana , Balau Radu Alexandru , Suciu Horatiu
Published: December 2024

Background/Objectives: In recent decades, the advantages of minimizing surgical trauma have led to the development of minimally invasive surgical procedures. While the benefits often outweigh the risks, several challenges are encountered that are not present in conventional surgical approaches. Unilateral pulmonary edema (UPE) after mitral interventions performed through a right-sided approach is a rare but potentially life-threatening event. Methods: We present the case of a 49-year-old patient who underwent endoscopic mitral valve repair. Immediately following ICU admission, the patient’s oxygen saturation suddenly dropped, and serous discharge was exteriorized from the endotracheal tube, with a thoracic X-ray revealing right-sided unilateral pulmonary edema. Results: The therapeutical course was complex. The patient developed hemodynamic instability, leading to cardiac arrest, which required cardiopulmonary resuscitation and the initiation of peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO). The endotracheal cannula was replaced with a right-sided double-lumen cannula, and the patient was placed on two ventilators operating independently. The patient was weaned off extracorporeal membrane oxygenation (ECMO) on the fifth day and extubated on the sixth postoperative day. Conclusions: We successfully treated this patient using ECMO and independent lung ventilation. Several cases have been described in the literature, but the pathogenesis and risk factors of UPE remain unclear. Management depends on the severity of UPE, but a deeper understanding of its underlying mechanisms could provide cardiac surgeons with enhanced strategies for preventing UPE and implementing timely interventions.
Experience of Metronidazole Triple Therapy After Clarithromycin Triple Therapy Failure for Helicobacter pylori Eradication in Korea
Authors: Lee Chang-Min , Kim Seong-Je , Choi Jung-Woo , Cho Hyun-Chin , Lee Ok-Jae
Published: December 2024

Background/Objectives: Bismuth quadruple therapy (BQT) is recommended as the best second-line regimen after failure of first-line clarithromycin triple therapy (CTT) for Helicobacter pylori eradication. However, there are some limitations to this approach, including the lack of an appropriate sequel regimen after failure of BQT and complicated administration. Metronidazole triple therapy (MTT) is simple to administer, but it is not widely recommended. This study was conducted to determine the efficacy of MTT as second-line regimen for H. pylori eradication after failure of CTT. Methods: We retrospectively reviewed the medical records of the Korean patients with H. pylori infection who underwent second-line treatment after failure of first-line CTT from October 2013 to October 2019. The efficacy of MTT and BQT for H. pylori eradication was compared. Results: The eradication rate in the BQT group tended to be higher than that in the MTT group; however, the difference was not statistically significant (208/233, 89.3% versus 244/284, 85.9%, p = 0.287). Among 40 patients with second-line MTT eradication failure, 21 received the third-line BQT, and 15 showed successful eradication (15/21, 71.4%). In the men 70 years or older, the eradication rate of MTT was lower than that of BQT without statistical significance (75.8% versus 94.1%, p = 0.141). Conclusions: These findings suggested that MTT could be a second-line treatment option, reserving BQT for Helicobacter pylori eradication after first line CTT failure, except in elderly men 70 years or older.
Targeted Motor Control Considering Sternal Position Improves Spinal Alignment in Pregnant Women at Risk for Preterm Birth with Low Back Pain
Authors: Żurawski Arkadiusz , Ha Sun , Świercz Grzegorz , Adamczyk Gruszka Olga , Kiebzak Wojciech
Published: December 2024

Background: Lumbopelvic pain (LBP) is a prevalent condition during pregnancy, affecting a significant proportion of pregnant women. It arises from hormonal, biomechanical, and postural changes, often exacerbating discomfort and impairing quality of life. This study aimed to evaluate the effects of targeted motor control interventions focusing on sternal alignment on spinal alignment, pain, and muscle activity in pregnant women at risk of preterm birth. Methods: This pre–post quasi-experimental study included 32 pregnant women at 28–32 weeks of gestation, who were hospitalized due to the risk of preterm birth. Inclusion criteria required participants to have LBP lasting at least two weeks and the ability to walk and stand for 40 min. The intervention involved targeted motor control exercises designed to optimize sternal and sacral alignment. Spinal alignment, pain intensity, and muscle activity were measured pre- and post-intervention using the DIERS formetric system, numerical rating scale (NRS), and electromyography (EMG), respectively. Data were analyzed using Wilcoxon signed-rank tests. Results: Significant improvements were observed in spinal alignment parameters, including reductions in the sternal angle, sacral angle, cervical and lumbar lordosis depths, thoracic kyphosis angle, and pelvic tilt (p < 0.05). Pain intensity decreased significantly from a mean NRS score of 5.77 ± 1.42 in the relaxed posture to 2.54 ± 0.71 in the corrected posture (p < 0.05). Muscle activity of the rhomboid muscles increased in the corrected posture, correlating with improved thoracic kyphosis, while activity of the serratus anterior muscle showed reductions (p < 0.05). Conclusions: Targeted motor control focusing on sternal alignment effectively improved spinal alignment and reduced pain in pregnant women at risk of preterm birth with LBP. The intervention offers a safe, non-invasive, and practical approach to managing pregnancy-related musculoskeletal challenges. Future research should validate these findings in diverse populations and explore long-term effects and broader clinical applications.
A Pilot Study on the Replacement of Fibrinogen with Fibrinogen Concentrates During Therapeutic Plasma Exchange with Mild to Moderate Bleeding Risk—A Comparison with Fresh Frozen Plasma and Albumin Replacement
Authors: Zrimsek Matej , Gubensek Jakob , Marn Pernat Andreja
Published: December 2024

Background: Therapeutic plasma exchange (TPE) removes coagulation factors and leads to depletion coagulopathy. The aim of the study was to compare hemostasis between TPE procedures without coagulation factor replacement (electrolyte group), the partial replacement of fibrinogen with fibrinogen concentrates (fibrinogen group) and partial coagulation factors replacement with fresh frozen plasma (partial FFP group). Methods: A total of 73 TPE procedures in patients with fibrinogen levels 1–2 g/L were divided into three study groups depending on clinically estimated bleeding risk. Standard coagulation and ROTEM® tests were performed before and after TPE. Results: Fibrinogen levels before TPE (p = 0.88) and after TPE (p = 0.33) were comparable between the fibrinogen and partial FFP groups. INR and ROTEM® parameters reflected moderately worse hemostasis after TPE with fibrinogen-only replacement compared to partial FFP replacement, which could result in increased bleeding risk. In the electrolyte group, most laboratory tests confirmed the most deranged hemostasis after TPE, as compared to fibrinogen or partial FFP replacement. A mild allergic reaction to FFP infusion was noted during one TPE. No clinically significant bleeding occurred in any of the study groups. Conclusions: Fibrinogen concentrate supplementation and partial FFP replacement can both maintain fibrinogen levels > 1 g/L after TPE, but modest differences in classical coagulation tests and bedside ROTEM® tests favor FFP replacement (NCT03801135).
Postprocedural Contrast-Associated Acute Kidney Injury and Prognosis of Patients Undergoing Recanalization of Chronic Total Occlusions
Authors: Hamzaraj Kevin , Demirel Caglayan , Gyöngyösi Mariann , Bartko Philipp E. , Hengstenberg Christian , Frey Bernhard , Hemetsberger Rayyan
Published: December 2024

Introduction: Percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) requires advanced techniques and prolonged procedural efforts, often necessitating high contrast volumes, which may increase the risk of contrast-associated acute kidney injury (CA-AKI). However, evidence suggests that factors beyond contrast exposure contribute to CA-AKI, though data specific to CTO PCI remain limited. Methods: Patients undergoing contemporary CTO PCI at our university-affiliated tertiary care center were enrolled. CA-AKI was defined according to KDIGO criteria, and patients were stratified based on the presence of postprocedural CA-AKI. Baseline and procedural characteristics, including osmotic factors, were compared between the groups. The primary outcome was all-cause mortality at one year, and the secondary outcome was all-cause mortality at three years. Results: A total of 145 patients were enrolled, with a mean age of 67 years, and 75% were male. Baseline creatinine levels, electrolytes, and osmotic factors did not differ significantly between groups. Lesion parameters and J-CTO scores were also comparable. The contrast volume and procedural duration were numerically higher in patients who developed CA-AKI. Patients with CA-AKI received a higher radiation dose (22.1 vs. 13.2 Gy·cm2, p = 0.041). CA-AKI emerged as an independent predictor of all-cause mortality at one year (adjusted HR 5.3, CI [1.52–18.51], p = 0.009) but not at three years. Conclusions: In this retrospective analysis, CA-AKI was an independent predictor of all-cause mortality at one year following CTO PCI but lost predictive value at three years. Baseline renal function and contrast volume alone did not predict CA-AKI. Instead, procedural complexity, reflected by higher radiation exposure, was associated with an elevated risk of CA-AKI.
Stoma Acceptance Mediates Body Image Distress and Mental Health-Related Quality of Life: A Single-Center Study on Radical Cystectomy Patients with Ureterostomy
Authors: Muzii Benedetta , Di Bello Francesco , Collà Ruvolo Claudia , Morra Simone , Polverino Federico , Pessolano Colomba , Creta Massimiliano , Califano Gianluigi , Pezone Gabriele , Mangiapia Francesco , Alvino Pierluigi , Longo Nicola , Maldonato Nelson Mauro
Published: December 2024

Background: Muscle-invasive bladder cancer and subsequent radical cystectomy with ureterocutaneostomy significantly impact patients’ body image and quality of life, potentially increasing the risk of adverse mental health outcomes. Acceptance may represent a psychosocial resource to buffer the effects of body image impairment on health, thereby supporting stoma adjustment and preserving quality of life. Objective: This study aimed to investigate the mediating role of stoma acceptance in the relationship between body image distress and mental health. Methods: A single-center cross-sectional survey was conducted with 73 muscle-invasive bladder cancer patients undergoing radical cystectomy with ureterocutaneostomy. Participants completed structured, anonymous self-report measures assessing body image distress, stoma acceptance, and mental health-related quality of life through validated questionnaires. Results: Statistical analyses revealed significant negative correlations between body image distress and mental health and stoma acceptance. Conversely, stoma acceptance was significantly and positively associated with mental health. Regression-based mediation modeling indicated that stoma acceptance exerted a significant mediating effect on the relationship between body image and mental health-related quality of life. Conclusions: These findings highlight the considerable and unprecedented role of stoma acceptance as a mediating factor that may promote the adjustment and enhance the quality of life of urostomy patients. Further research is warranted to explore interventions targeting stoma acceptance to prevent body image distress and promote mental health.
Kisspeptin and Endometriosis—Is There a Link?
Authors: Meczekalski Blazej , Nowicka Agata , Bochynska Stefania , Szczesnowicz Aleksandra , Bala Gregory , Szeliga Anna
Published: December 2024

This article presents a narrative review that explores the potential link between kisspeptin—a key regulator of the hypothalamic-pituitary-gonadal axis—and the pathogenesis of endometriosis. Kisspeptin plays a significant role in regulating reproductive functions by modulating the release of gonadotropin-releasing hormone (GnRH), which in turn stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Recent studies suggest that kisspeptin may also impact peripheral reproductive tissues and influence inflammatory processes involved in the development of endometriosis. Altered kisspeptin signaling has been associated with the abnormal hormonal environment observed in endometriosis, which affects menstrual cycles and ovarian function. Research indicates that women with endometriosis exhibit altered levels of kisspeptin and its receptor, KISS1R, in both eutopic and ectopic endometrial tissues, suggesting a role in disease progression, particularly in tissue invasion and lesion formation. Kisspeptin’s role in regulating matrix metalloproteinases (MMPs), enzymes essential for tissue remodeling, further supports its potential contribution to the pathophysiology of endometriosis. Moreover, kisspeptin-based therapeutic strategies are currently under investigation, with the aim of providing targeted treatments that reduce the side effects commonly associated with existing therapies. Despite promising findings, further research is needed to fully understand the mechanisms by which kisspeptin influences endometriosis.
Age Variation in Patients with Troponin Level Elevation Without Obstructive Culprit Lesion or Suspected Myocardial Infarction with Non-Obstructive Coronary Arteries—Long-Term Data Covering over Decade
Authors: Abumayyaleh Mohammad , Schlettert Clara , Materzok Daniel , Mügge Andreas , Hamdani Nazha , Akin Ibrahim , Aweimer Assem , El-Battrawy Ibrahim
Published: December 2024

Background/Objectives: Troponin level elevation without an obstructive culprit lesion is caused by heterogenous entities. The effect of aging on this condition has been poorly investigated. Methods: After screening 24,775 patients between 2010 and 2021, this study included a total of 373 patients with elevated troponin levels without an obstructive culprit lesion or suspected myocardial infarction with non-obstructive coronary arteries (MINOCAs) categorized into four age groups containing 78 patients (<51 years), 72 patients (51–60 years), 81 patients (61–70 years), and 142 patients (>70 years). This study analyzed the baseline characteristics, the in-hospital complications, in-hospital mortality, and the long-term outcomes. Results: The older patients exhibited a higher rate of major adverse cardiovascular in-hospital events than those of the other age groups (15.4% in the <51-year-old group vs. 36.1% in the 51–60-year-old group vs. 33.3% in the 61–70-year-old group vs. 47.2% in the >70-year-old group; p < 0.001). However, the rate of non-sustained ventricular tachycardia (nsVT) was higher in the 51–60-year-old patients than those of the other age groups (5.6% in the 51–60-year-old group vs. 1.3% in the 61–70-year-old group vs. 0.7% in the >70-year-old group; p = 0.027). At the 11-year follow-up, cardiovascular mortality was higher among the older patients compared to that of the younger patients (3.9% in the 61–70-year-old group vs. 4.2% in the >70-year-old group, p = 0.042), while non-cardiovascular mortality was comparable between the age groups. Conclusions: The older patients with troponin level elevation without an obstructive culprit lesion experienced a higher incidence of major adverse cardiovascular events during hospitalization compared to that of the younger groups. Additionally, higher cardiovascular mortality rates were revealed in the older patients at a long-term follow-up.
Catheter Ablation in Atrial Fibrillation: Recent Advances
Authors: Singh Sahib , Garg Lohit , Kanjwal Mohammed Y. , Bliden Kevin , Tantry Udaya S. , Gurbel Paul A. , Alraies M. Chadi , Damluji Abdulla A.
Published: December 2024

Atrial fibrillation (AF) is the leading cause of arrhythmia-related morbidity and mortality. Recurrent symptoms, hospitalizations, and cost burden to patients have necessitated treatments beyond antiarrhythmic drugs (AADs) for patients with AF. Catheter ablation has proven to be effective over medical therapy alone; however the recurrence rates for atrial tachyarrhythmias post-ablation remain significant, particularly in patients with persistent and long-standing persistent AF. Hence, new techniques for catheter ablation have arisen, such as non-thermal energy sources, novel catheters, electroanatomical mapping, and ablation of additional targets. In this review, we discuss the recent advances in the field of catheter ablation, including newer modalities for the prevention of adverse events and future perspectives.
Predictive Molecular Biomarkers of Bladder Cancer Identified by Next-Generation Sequencing—Preliminary Data
Authors: Myszka Aleksander , Ciesla Marek , Siekierzynska Aleksandra , Sendera Anna , Constantinou Constantina , Karpinski Pawel , Wysiadecki Grzegorz , Balawender Krzysztof
Published: December 2024

Background: The majority of patients with bladder cancer suffer from tumour recurrence. Identifying prognostic factors for tumour recurrence is crucial for treatment and follow-up in affected patients. The study aimed to assess the impact of somatic mutations in bladder cancer on patient outcomes and tumour recurrence. Methods: The study group comprised 46 patients with urothelial bladder cancers referred for transurethral resection of the tumour. A molecular study on tumour-derived DNA was performed using next-generation sequencing. Somatic mutations were screened in 50 genes involved in carcinogenesis. Results: We identified 81 variants in 23 genes, including 54 pathogenic mutations, 18 likely pathogenic variants, and 9 variants of unknown significance. The most frequently mutated genes were FGFR3, PIK3CA, and TP53 in 52%, 35%, and 24% of tumours, respectively. The average tumour-free survival was significantly longer in cases with mutations in the PIK3CA gene (p = 0.02), and mutations in the PIK3CA gene were associated with a decreased risk of tumour recurrence (Hazard Ratio = 0.26; 95% CI: 0.11–0.62; p = 0.018). Conclusions: The PIK3CA gene was shown to be a predictive marker of a low risk of bladder tumour recurrence. Molecular screening of bladder cancers supported predictive biomarkers of tumour recurrence and showed that tumour-free survival is molecularly determined.
Predicting Intensive Care Unit Admission in COVID-19-Infected Pregnant Women Using Machine Learning
Authors: Mukhamediya Azamat , Arupzhanov Iliyar , Zollanvari Amin , Zhumambayeva Saule , Nadyrov Kamalzhan , Khamidullina Zaituna , Tazhibayeva Karina , Myrzabekova Aigul , Jaxalykova Kulyash K. , Terzic Milan , Bapayeva Gauri , Kulbayeva Saltanat , Abuova Gulzhan Narkenovna , Erezhepov Baktigali Aubayevich , Sarbalina Asselzhan , Sipenova Aigerim , Mukhtarova Kymbat , Ghahramany Ghazal , Sarria-Santamera Antonio
Published: December 2024

Background: The rapid onset of COVID-19 placed immense strain on many already overstretched healthcare systems. The unique physiological changes in pregnancy, amplified by the complex effects of COVID-19 in pregnant women, rendered prioritization of infected expectant mothers more challenging. This work aims to use state-of-the-art machine learning techniques to predict whether a COVID-19-infected pregnant woman will be admitted to ICU (Intensive Care Unit). Methods: A retrospective study using data from COVID-19-infected women admitted to one hospital in Astana and one in Shymkent, Kazakhstan, from May to July 2021. The developed machine learning platform implements and compares the performance of eight binary classifiers, including Gaussian naïve Bayes, K-nearest neighbors, logistic regression with L2 regularization, random forest, AdaBoost, gradient boosting, eXtreme gradient boosting, and linear discriminant analysis. Results: Data from 1292 pregnant women with COVID-19 were analyzed. Of them, 10.4% were admitted to ICU. Logistic regression with L2 regularization achieved the highest F1-score during the model selection phase while achieving an AUC of 0.84 on the test set during the evaluation stage. Furthermore, the feature importance analysis conducted by calculating Shapley Additive Explanation values points to leucocyte counts, C-reactive protein, pregnancy week, and eGFR and hemoglobin as the most important features for predicting ICU admission. Conclusions: The predictive model obtained here may be an efficient support tool for prioritizing care of COVID-19-infected pregnant women in clinical practice.
The Role of Minoxidil in Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis
Authors: Majewski Michał , Gardaś Karolina , Waśkiel-Burnat Anna , Ordak Michał , Rudnicka Lidia
Published: December 2024

Background/Objectives: Minoxidil, in addition to its vasodilatory effect, has also immunomodulatory properties that may be partially responsible for its efficacy in alopecia areata. The aim of the study was to evaluate the efficacy of monotherapy with topical or oral minoxidil in alopecia areata. Methods: A systematic review and meta-analysis of the efficacy of monotherapy with minoxidil in alopecia areata was conducted following the PRISMA guidelines. Efficacy of minoxidil in alopecia areata was evaluated separately for three groups of the patients: (1) treated with 5% topical minoxidil, (2) less than 5% topical minoxidil, and (3) oral minoxidil. Therapeutic response was defined as any regrowth of terminal hair. Results: Of 244 articles, 13 were considered eligible for the further analysis. The study included 372 patients with alopecia areata (338 using topical minoxidil and 34 taking oral minoxidil). The mean time of treatment ranged from 2 to 60 weeks (mean: 27 weeks). The response rate for 5% topical was 82% (95% CI 0.7–0.93) and 58% (95% Cl 0.5–0.67) for the less than 5% topical minoxidil group. For the group of patients treated orally, the response rate was 82%. Conclusions: Minoxidil, both topical and oral, may be beneficial in monotherapy in patients with alopecia areata. 5% topical minoxidil is characterized by significantly higher efficacy compared to minoxidil at a lower concentration. There are no sufficient data to recommend minoxidil as a first-line therapeutic option for alopecia areata.
Spatial Prediction of Soil Total Phosphorus in a Karst Area: Comparing GWR and Residual-Centered Kriging
Authors: Lu Laimou , Li Penghui , Zhong Liang , Luo Mingbao , Xing Liyuan , Zhang Chunlai
Published: December 2024

Accurate soil total phosphorus (TP) prediction is essential to support sustainable agricultural practices and formulate ecological conservation protection policies, particularly in complex karst landscapes with high spatial variability and high phosphorus and cadmium content and interactions, complicating nutrient management. This study uses GIS and geostatistical methods to analyze the spatial distribution, influencing factors, and predictive modeling of soil TP in the karst region of northern Mashan County, Guangxi, China. Using 427 surface soil samples, we developed five predictive models: ordinary kriging (OK), regression kriging (RK) and geographically weighted regression kriging (GWRK) combined with environmental variables such as land uses, soil types, and topographic factors; residual mean-centered kriging (MM_OK), and residual median-centered kriging (MC_OK). Our results indicate that higher TP levels were observed in agricultural lands (paddy fields and dry land, at 766 and 913 mg·kg−1, respectively) may due to fertilization, while forests and shrublands showed lower TP levels (383 and 686 mg·kg−1, respectively), reflecting natural phosphorus cycling. The high-value areas of soil TP concentration are in the karst areas in the west and east of the study area, and the low-value area is in the Hongshui River valley in the north of Mashan. The spatial distribution of soil TP is affected by land use, soil type, and topography. The GWRK model exhibited superior accuracy (80.6%), with predicted concentration of TP closely aligning with observed TP values, effectively capturing fine spatial variations, and showing the lowest mean standardized error, average standard error, and mean absolute error. GWRK also achieved the highest R2 (0.67), demonstrating robust predictive capability. MM_OK and MC_OK models performed well and showed smoother spatial transitions, while the OK model displayed the lowest predictive accuracy (62%). By utilizing spatially adaptive weighting, GWRK and its residual-centered kriging method improve soil TP’s prediction accuracy and smoothness in karst areas, providing a reference for targeted soil conservation and sustainable agricultural practices in spatially complex karst environments.
Ecological Network Construction Based on Ecosystem Services and Landscape Pattern Indices in the Tabu River Basin
Authors: Zhang Weichen , Fan Yuyang , Wang Bojie
Published: December 2024

Unsustainable human activities threaten the ecological security of arid and semi-arid watersheds. However, improving the connectivity of ecological networks can enhance ecosystem services and preserve biodiversity in these fragile environments. In this study, we aimed to identify ecological sources of the Tabu River Basin by quantifying five key ecosystem services and using a morphological spatial pattern analysis model. We further optimized resistance surfaces using landscape pattern indices, constructed an ecological network, and provided recommendations for sustainable management. The results obtained were as follows: (1) Ecosystem services in the Tabu River Basin exhibit clear spatial heterogeneity, with significant increases in water yield, food supply, and carbon sequestration over the past two decades. (2) Landscape pattern indices, such as the aggregation index, patch cohesion index, and Shannon’s diversity index, showed declines, indicating heightened landscape fragmentation and reduced connectivity. (3) Over the study period, the number of ecological sources increased from 6 to 17, although the total area of these sources decreased. The number of corridors expanded from 9 to 36, with a total length increase of 362.47 km, whereas pinch points increased from 27 to 40. (4) After optimization, one additional corridor and 24 new pinch points were identified, alongside a marked reduction in resistance in the northern and central-western regions. These results provide a robust scientific basis for optimizing land-use planning and reinforcing ecological security in the Tabu River Basin.
Immunohistochemical Evaluation of Basal and Luminal Markers in Bladder Cancer: A Study from a Single Institution
Authors: Do Anh Toan , Pham Quoc Thang , Nguyen Ngoc Minh Tam , Nguyen Phuc Nguyen , Bui Thi Thanh Tam , Ngo Quoc Dat
Published: December 2024

Background: Bladder cancer (BC) presents significant molecular diversity, which affects both prognosis and treatment results. Immunohistochemistry (IHC) facilitates the identification of molecular subtypes and their relationships with clinicopathological features. Methods: We performed an IHC analysis on tissue samples from 107 BC patients, evaluating the expression of markers GATA3, CD44, CK5/6, and CK20. We applied two methods to classify the tumor samples into basal and luminal subtypes. The relationships between these marker expressions, molecular subtypes, clinicopathological characteristics, and TILs were explored. Results: Most samples showed the expression of GATA3 and CD44, with notable correlations found between CD44 and CK5/6 as well as GATA3 and CK20. CD44 and CD20 expression were linked to a poorer prognosis. Additionally, the luminal and basal subtypes had distinct TIL patterns, which influenced overall survival. A poor prognosis was associated with the basal subtype with low TIL infiltration and the luminal subtype with high TIL infiltration. Conclusions: Our study clarifies the molecular characteristics of BC, underlining the prognostic importance of CD44 expression and the role of TILs in influencing subtype-specific outcomes. IHC proves valuable in subtype identification and supports personalized treatment strategies.
Effect of Indenter Load on Vickers Microhardness and Indentation Depth of One Resin Composite
Authors: Price Richard B. , Sullivan Braden
Published: December 2024

The load and size of the indentation may affect the hardness value. This study investigated the effect of the indentation size on the microhardness of one resin-based composite (RBC). Metal molds 4 mm deep and 12 mm in diameter were filled with Tetric EvoCeram Bulk Fill (Ivoclar) and light-cured for 10 s using a broad-spectrum LED curing light. The Vickers microhardness and the degree of conversion (DC) at the top and bottom surfaces were measured 24 h later before and after polishing the RBC. The microhardness measurements were made using 50, 100, 300 and 1000-gf loads with the same 8 s dwell time. The DC was measured in the same region using mid FT-IR spectroscopy. Repeated measures analysis of variance tests were used to determine if the surface (top vs. bottom) or the indenter loads had a significant effect on the VH, or if polishing affected the VH and the DC (alpha = 0.05). It was found that the indenter load did not affect the Vickers hardness of the unpolished top surface (p = 0.759), the polished top surface (p = 0.374), or the polished bottom surface (p = 0.083) of the Tetric EvoCeram Bulk Fill. Increasing the indenter load did increase the VH of the unpolished surface at the bottom (p < 0.0001). Polishing increased the DC by 13.5% at the top and by 46.7% at the bottom surface.
Conversion of Oil-Containing Residue from Waste Oil Recycling Plant into Porous Carbon Materials Through Activation Method with Phosphoric Acid
Authors: Kuo Li-An , Tsai Wen-Tien , Pan Chien-Chen , Ye Ya-Chen , Tsai Chi-Hung
Published: December 2024

In the waste oil recycling industry, large amounts of oil-containing sludge are still generated, thus posing a resource depletion issue when disposed of or incinerated without energy recovery or residual oil utilization. In this work, chemical activation experiments using phosphoric acid (H3PO4) were performed at a low temperature (600 °C) for 30 min to produce porous carbon products. From the results of the pore property analysis, an increasing trend with an increasing impregnation ratio from 0.5 to 2.0 was observed. Based on the Brunauer–Emmett–Teller (BET) model, the maximal BET surface area was about 70 m2/g, which was indicative of the hysteresis loop and the type IV isotherms in the resulting carbon product. In addition, the enhancement in the pore properties of the carbon products obtained through acid-washing was superior to that achieved through water-washing and without post-washing. From observations made using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS), the carbon products featured a porous structure and inherent magnetism due to their richness of iron oxides. In this regard, they can be used as efficient adsorbents or catalyst supports due to their simple recovery (or separation) when exhausted.
Study on the Curing Behaviors of Benzoxazine Nitrile-Based Resin Featuring Fluorene Structures and the Excellent Properties of Their Glass Fiber-Reinforced Laminates
Authors: Xu Mingzhen , He Lunshuai , Zhang Jiaqu , Fan Zexu , Li Bo
Published: December 2024

Benzoxazine and o-phthalonitrile resin are two of the most eminent polymer matrices within high-performance fiber-reinforced resin-based composite materials. Studying the influence modalities of their structures and forming processes on performance can furnish a theoretical basis for the design and manufacturing of superior performance composite materials. In this study, we initially incorporated a fluorene structure into the molecular main chain through molecular design to prepare a fluorene-containing benzoxazine nitrile-based resin. The polymerization reaction behavior and process of this resin were monitored meticulously using differential scanning calorimetry and infrared spectroscopy. Meanwhile, by manipulating the pre-polymerization reaction conditions, the impact of the pre-polymerization reaction on the polymerization behavior of the resin monomer was investigated, respectively. Subsequently, diverse glass fiber-reinforced resin-based composite materials were fabricated via hot-pressing in combination with a programmed temperature rise process. Through the characterization of structural strength and thermomechanical properties, it was found that the composite laminates all manifested outstanding bending strength (~600 MPa) and modulus (>30 GPa). Nevertheless, with the elevation of the post-curing temperature, the structural strength and modulus of the composite materials displayed distinct variation laws. This study also discussed the variation laws of the thermal properties of the composite materials by analyzing the glass transition temperature and crosslinking density. Additionally, the interface bonding effect between the glass fiber and the resin matrix was deliberated through the analysis of the cross-sectional morphology of the composite laminates. The results demonstrated that this work proposes an improved matrix resin system with outstanding thermal stability and mechanical properties that broadens the foundation and ideas for subsequent research.
Combined Reaction System for NH3 Decomposition and CO2 Methanation Using Hydrogen Permeable Membrane Reactor in 1D Model Analysis
Authors: Permatasari Putri , Goto Haruka , Miyamoto Manabu , Oumi Yasunori , Budhi Yogi Wibisono , Uemiya Shigeyuki
Published: December 2024

In a previous study, we developed an integrated reaction system combining NH3 decomposition and CO2 methanation within a membrane reactor, significantly enhancing reactor performance through efficient H2 separation. Ru/Ba/γ-Al2O3 and Ru/ZrO2 were employed as catalysts for each reaction. To ensure the accuracy and reliability of our results, they were validated through 1D models using FlexPDE Professional Version 7.21/W64 software. Key parameters such as reactor arrangement, catalyst bed positioning, overall heat transfer coefficient, rate constants, and H2 permeance were investigated to optimize system efficiency. The study revealed that positioning the NH3 decomposition on the shell side and CO2 methanation on the tube side resulted in a better performance. Additionally, shifting the methanation catalyst bed downward by approximately one-eighth (10 mm from 80 mm) achieves the highest CO2 conversion. A sensitivity analysis identified the rate constant of the NH3 decomposition catalyst and the H2 permeance of the membrane as the most influential factors in enhancing CO2 conversion. This highlights the priority of improving membrane H2 permeance and catalytic activity for NH3 decomposition to maximize system efficiency.
Thin-Film Deposition: From Fundamental Research to Applications
Authors: Rivera Reséndiz Laura Patricia , Quiñones Galván José Guadalupe
Published: December 2024

In recent decades, we have witnessed incredible advancements in technology [...]
The Preparation of High-Performance MoO3 Nanorods for 2.1 V Aqueous Asymmetric Supercapacitor
Authors: Lian Ziyu , Mao Xiling , Song Yi , Yao Kaihua , Zhang Ruifeng , Yan Xinyu , Li Mengwei
Published: December 2024

In order to broaden the working voltage (1.23 V) of aqueous supercapacitors, a high-performance asymmetric supercapacitor with a working voltage window reaching up to 2.1 V is assembled using a nanorod-shaped molybdenum trioxide (MoO3) negative electrode and an activated carbon (AC) positive electrode, as well as a sodium sulfate–ethylene glycol ((Na2SO4-EG) electrolyte. MoO3 electrode materials are fabricated by adjusting the hydrothermal temperature, hydrothermal time and solution’s pH value. The specific capacity of the optimal MoO3 electrode material can reach as high as 244.35 F g−1 at a current density of 0.5 A g−1. For the assembled MoO3//AC asymmetric supercapacitor with a voltage window of 2.1 V, its specific capacity, the energy density, and the power density are 13.52 F g−1, 8.28 Wh kg−1, and 382.15 W kg−1 at 0.5 A g−1, respectively. Moreover, after 5000 charge–discharge cycles, the capacity retention rate of the device still reaches 109.2%. This is mainly attributed to the small particle size of MoO3 nanorods, which can expose more electrochemically active sites, thus greatly facilitating the transport of electrolyte ions, immersion at the electrolyte/electrolyte interface and the occurrence of electrochemical reactions.
Magnetically Controlled Transport of Nanoparticles in Solid Tumor Tissues and Porous Media Using a Tumor-on-a-Chip Format
Authors: Zimina Tatiana , Sitkov Nikita , Brusina Ksenia , Fedorov Viacheslav , Mikhailova Natalia , Testov Dmitriy , Gareev Kamil , Samochernykh Konstantin , Combs Stephanie , Shevtsov Maxim
Published: December 2024

This study addresses issues in developing spatially controlled magnetic fields for particle guidance, synthesizing biocompatible and chemically stable MNPs and enhancing their specificity to pathological cells through chemical modifications, developing personalized adjustments, and highlighting the potential of tumor-on-a-chip systems, which can simulate tissue environments and assess drug efficacy and dosage in a controlled setting. The research focused on two MNP types, uncoated magnetite nanoparticles (mMNPs) and carboxymethyl dextran coated superparamagnetic nanoparticles (CD-SPIONs), and evaluated their transport properties in microfluidic systems and porous media. The original uncoated mMNPs of bimodal size distribution and the narrow size distribution of the fractions (23 nm and 106 nm by radii) were demonstrated to agglomerate in magnetically driven microfluidic flow, forming a stable stationary web consisting of magnetic fibers within 30 min. CD-SPIONs were demonstrated to migrate in agar gel with the mean pore size equal to or slightly higher than the particle size. The migration velocity was inversely proportional to the size of particles. No compression of the gel was observed under the magnetic field gradient of 40 T/m. In the brain tissue, particles of sizes 220, 350, 820 nm were not penetrating the tissue, while the compression of tissue was observed. The particles of 95 nm size penetrated the tissue at the edge of the sample, and no compression was observed. For all particles, movement through capillary vessels was observed.
The Influence of Diet and Obesity in Lynch Syndrome: What Do We Know So Far
Authors: Rodrigues Cláudio , Irving Susana Couto , Alves Paula , Dinis-Ribeiro Mário , Brandão Catarina , Correia Marta
Published: December 2024

Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS’s clinical evolution. There is some evidence suggesting that individuals living with LS should follow general guidelines for diet and alcohol restriction/moderation, so as to achieve and maintain a favorable weight status and overall health and quality of life. However, more research is needed, preferentially from clinical studies of a prospective nature with robust designs, to better inform diet and behavioral patterns targeting cancer prevention in LS.
Exploring Partners’ Part in Shaping the Home Food Environment During the Transition to Fatherhood
Authors: Peles Chagit , Rudolf Mary C. J. , Shloim Danielle , Shloim Netalie
Published: December 2024

Objective: To investigate primiparous women’s partners for knowledge, attitudes, and practices regarding the physical home food environment (PHFE), and to assess if the first pregnancy provides a teachable opportunity to enhance the PHFE of first-time pregnant couples. Design: This was a two-phase longitudinal in-depth qualitative study involving questionnaires and individual interviews during and after pregnancy. Participants: Fifteen male partners of primigravida women. Main outcome measures: Knowledge, attitudes, and behaviors concerning PHFE; lifestyle and dietary habits; and interest in guidance regarding healthy PHFE during the first pregnancy and the transition to parenthood. Analysis involved descriptive statistics and thematic analysis for qualitative data. Results: Key findings include the importance of mutual prenatal PHFE decisions; increased motivation for a healthier PHFE during pregnancy; a desire to provide a healthier environment than their own parents offered, acknowledgement of their wives as ‘nutrition experts’; challenges in accessibility of health foods in the home; and ‘the child eats what we eat’. The first pregnancy was recognized as a critical period for establishing a healthy PHFE. Conclusions and Implications: Expectant fathers have a crucial role in nestrition (nutritional nesting) in first pregnancies. Their engagement is essential in establishing a more supportive nutritional environment in the home and influencing the family nutrition in the long term. There is a need to promote partner involvement, investigate the broader roles of expectant fathers and non-male partners, and develop effective PHFE education for couples in the first pregnancy.